bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnosis and Treatment of Orbital Solitary Fibrous Tumor
Authors: Ren Mingyu , Wu Yixiang , Li Ruimiao , Li Jing , Wang Jingjing , Liu Limin , Gao Yu 
Published: November 2020

Abstract
BackgroundSolitary fibrous tumor (SFT) is an uncommon spindle-cell tumor of mesenchymal origin, it commonly occurs within pleura, the occurrence of SFT in the orbit is very rare. The diagnosis of orbital SFT is challenging in clinical, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings.MethodsIn our retrospective study, we collected 13 patients with orbital SFT. All patients were diagnosed with orbital SFT by postoperative histopathological and immunohistochemical examination. Patient charts and medical records were reviewed for demographic information, relevant medical and family history, clinical presentation, radiological examination, histopathological and immunohistochemical examination, the treatment and prognosis.ResultsThis study included 7 males and 6 females. The age ranged from 11 to 78 years. 7 patients presented with predominant features of exophthalmos. 7 patients showed eyeball dislocation. 6 patients with motility disturbances. 9 patients had the palpable masses. 6 patients had the secondary lesions. On CT scan, there were 6 patients were located in the superomedial quadrant of the orbit, 3 patients were located in the inferomedial quadrant of the orbit. The morphology of lesions was solitary ovoid mass in 10 patients, and irregular mass in 3 patients. The CT value of the tumor was 22.8-64.4Hu, with the median of 45.9Hu. On MRI, 3 patients showed hypointense mixed signals on T1WI, 10 patients showed isointense mixed signal on T1WI. 3 patients showed hypointense mixed signals, 4 patients showed isointense mixed signals, 6 patients showed hyperintense signals on T2WI. There were 12 patients showed obviously enhancement, and we found patchy lesions which were no enhancement in the tumor. All patients were treated by surgery. Immunohistochemical analysis showed that the tumor cells exhibited diffuse immunoreactivity for CD34 and CD99 in all the patients. The lesions were positive for Bcl-2 in 11 patients. The lesions were positivity for Ki-67 <5% in one patient, 5%-10% in 10 patients, >10% in 2 patients. ConclusionsThe lesions are often outside the muscular cone, most commonly located at superomedial quadrant and inferomeddial quadrant of the orbit. The density of the lesions is uneven in most cases, the mean CT values of the tumors on CT scans are variable. The signal of lesions on orbital MRI is uncertainty, it is inheterogeneous enhancement, and the lamellar unenhanced regions can also be found in the lesion. The complete gross resection, and even more aggressive wide excision is preferred. Although the Ki-67 labelling index is very low, malignant forms with an increased propensity for local recurrence have been found. A longer follow-up is needed to determine the recurrence rate of the disease, and to identify the causes of recurrence.
Urban -Rural Differential in the Association Between Household Wealth Index and Anemia Among Women in Reproductive Age in Ethiopia, 2016.
Authors: Assefa Sefealem , Demeke Dessalegn , Mesfine Mekuriaw , Getahun Biruk , Alemu Adela , Mengiste Yirga , Aknaw Getasew , Abie Dagninet , Abate Teshager 
Published: November 2020

Abstract
Background: Anemia is more prevalent among women, and it is a moderate public health problem in Ethiopia. The wealth status and place of residence of a woman have implications on the intervention of anemia. Studies that examined the relationship between women’s wealth index status and place of residency in Ethiopia are scarce. We aimed to identify the urban-rural differential in the association between household wealth index and anemia among women of childbearing age in Ethiopia. Method: A cross-sectional design was employed with nationally representative sample of 14100 women aged 15–49-year-old from the Ethiopian demographic and health survey conducted in 2016. Samples were selected by the two-stage clustering sampling method. The primary outcome was anemia in women of childbearing age. A hemoglobin level of below 11 g/dl for pregnant women and 12 g/dl for non-pregnant women was used as the indicator of anemia. Using a three-level random intercept model to explored associated factors at individual and household levels quantified the observed and unobserved variations between households’ wealth index and place of residence. Results: Women of low household wealth index category were anemic (29.6%) than those middle and rich wealth index categories. Women who live in rural areas were (25.5%) were anemic than those who live in urban. The odds of anemia were significantly higher in women of low household wealth category, compared to women of high household wealth category (AOR = 1.37, 95%CI = 1.14–1.65, P < 0.001). This is not true for women to live in urban residency. Conclusion: Since the driver of anemia in this study is the palace of residency affecting women of reproductive age groups, novel public health interventions should consider urban residency those women with the lowest household wealth status.
High-efficiency Wavelength Tunable Monolayer LED with Hybrid Continuous-pulsed Injection
Authors: Zhu Yi , Wang Bowen , Li Ziyuan , Zhang Jian , Tang Yilin , Torres Juan F , Lipiński Wojciech , Fu Lan , Lu Yuerui 
Published: November 2020

Abstract
High-efficiency and wavelength-tunable light emitting diode (LED) devices will play an important role in future advanced optoelectronic systems. Traditional semiconductor LED devices typically have a fixed emission wavelength that is determined by the energy of the emission states. Here, we developed a novel high-efficiency and wavelength-tunable monolayer WS2 LED device, which operates in the hybrid mode of continuous-pulsed injection. This hybrid injection enables highly enhanced emission efficiency (> 20 times) and the effective size of emission area (> 5 times) at room temperature. The emission wavelength of WS2 monolayer LED device can be tuned over more than 40 nm by driving AC voltages, from exciton emission to trion emission, and further to defect emissions. The quantum efficiency of defect electroluminescence (EL) emission is measured to be more than 24.5 times larger than that from free exciton and trion EL emissions. The separate carrier injection in our LED also demonstrate advantage in allowing to visualize and distinguish defect species in real space. Those defects are assigned to be negatively charged defects. Our results open a new route to develop high-performance and wavelength-tunable LED devices for future advanced optoelectronic applications.
Babao dan promotes apoptosis of cisplatin (DDP)-resistant gastric cancer cell line SGC-7901/DDP by inducing autophagy through PI3K/AKT/mTOR pathway modulation
Authors: Zhao Jinyan , Lan Weilan , Peng Jun , Guan Bin , Liu Jie , Zhang Min , Zhan Zhixue , Lin Jiumao 
Published: November 2020

Abstract
Background: Multidrug resistance (MDR) is a critical reason of cancer chemotherapy failure. Babao dan (BBD) is a classical and famous traditional Chinese patent medicine, which has been reported to has anti-gastric cancer activity. However, the roles and molecular mechanisms of the reversal of MDR of gastric cancer by BBD have not been well described until now. Methods: SGC-7901 and SGC-7901/DDP cells were used in this study, and drug resistance and evaluation of the reversal effect of BBD was determined using MTT assays in SGC7901/DDP cells. Doxorubicin (DOX) and Rhodamin123 (Rho123) staining was performed to assess BBD effects on drug accumulation and efflux of drug-resistant gastric cancer cells. Cell apoptosis was directly assessed using DAPI staining. Apoptotic and dead cells were detected by flow cytometry after staining with Annexin V-FITC and propidium iodide (PI). Cyto-ID assays were performed to examine cellular autophagy. Changes in cell protein expression of ABCB1, ABCC1, ABCG2, Bax, Bcl-2, caspase-3, cleaved-caspase-3, LC3, p62, Beclin1 and the PI3K/AKT/mTOR pathway were detected by Western blot. Inhibition of autophagy with 3-MA, chloroquine (CQ) and PI3K antagonist (LY294002) or agonist (740Y-P) , uncovered a role for the potentially downregulated signaling pathway, PI3K/AKT/mTOR.Results: The SGC7901/DDP cell line exhibited multi-drug resistance to DDP, DOX and 5-fluorouracil (5-FU) and the drug resistant index (RI) of DDP, DOX and 5-FU were 1.86, 1.50 and 47.70, respectively. BBD reversed the MDR of SGC7901/DDP cells by increasingDOX accumulation, reducing Rh123 efflux and down-regulating the expression of ABCB1, ABCC1, ABCG2. Furthermore, BBD induced apoptosis in SGC7901/DDP cells through regulating caspase-3, cleaved-caspase-3, Bax and Bcl-2. Moreover, BBD induced autophagy in DDP-resistant gastric cancer cells via regulating p62, LC3 and Beclin1. Pathway analyses suggested BBD may inhibit PI3K/AKT/mTOR pathway activity and subsequent autophagy induction. Conclusions: BBD may reverse the MDR of gastric cancer cells, and promote autophagic death via inactivation of the PI3K/AKT/mTOR signaling pathway.
Validation of the Framingham Hypertension Risk Score in A Middle Eastern Population: Tehran Lipid and Glucose Study (TLGS)
Authors: Koohi Fatemeh , Steyerberg Ewout , Cheraghi Leila , Abdshah Alireza , Azizi Fereidoun , Khalili Davood 
Published: November 2020

Abstract
Background: The Framingham hypertension risk score is a well-known and simple model for predicting hypertension in adults. In the current study, we aimed to assess the predictive ability of this model in a Middle Eastern population. Methods: We studied 5,423 participants, aged 20-69 years, without hypertension, who participated in two consecutive examination cycles of the Tehran Lipid and Glucose Study (TLGS). We assessed discrimination based on Harrell’s concordance statistic (c-index) and calibration (graphical comparison of predicted vs. observed). We evaluated the original, recalibrated (for intercept and slope), and revised (for beta coefficients) models. Results: Over the 3-year follow-up period, 319 participants developed hypertension. The Framingham hypertension risk score performed well in discriminating between individuals who developed hypertension and those who did not (c-index=0.81, 95% CI: 0.79-0.83). Initially, there was a systematic underestimation of the original risk score (events predicted), which was readily corrected by a simple model revision. Conclusions: The revised Framingham hypertension risk score can be used as a screening tool in public health and clinical practice to facilitate the targeting of preventive interventions in high-risk Middle Eastern people.
Developing A Diagnostic Decision Support System (DDSS) to Reduce Time To Diagnosis in Paediatric Shoulder Instability
Authors: Philp Fraser , Faux-Nightingale Alice , Wooley Sandra , De Quincey Ed , Pandyan Anand 
Published: November 2020

Abstract
Background: Currently the diagnosis of shoulder instability, particularly in children, is difficult and can take time. These diagnostic delays can lead to poorer outcome and long-term complications. A Diagnostic Decision Support System (DDSS) has the potential to reduce time to diagnosis improve outcomes for patients. The aim of this study was to develop a concept map for a future DDSS in shoulder instability.Methods: A modified nominal focus group technique, involving three clinical vignettes was used to elicit information physiotherapists decision-making processes.Results: Twenty-five physiotherapists, (18F:7M) from four separate clinical sites participated. The themes identified related to ‘Variability in diagnostic processes and lack of standardised practice’ and ‘Knowledge and attitudes towards novel technologies for facilitating assessment and clinical decision making’. Conclusion: No common structured approach towards assessment and diagnosis was identified. Lack of knowledge, perceived usefulness, access and cost were identified as barriers to adoption of new technology. Based on the information elicited a conceptual design of a future DDSS has been proposed. Work to develop a systematic approach to assessment, classification and diagnosis is now proposed.Trial Registration: This was not a clinical trial and so no clinical trial registry is needed.
Targeting Aurora B kinase with Tanshinone IIA Suppresses Tumor Growth and Overcomes Radioresistance
Authors: Li Ming , Gao Feng , liu haidan , Zhao Qin , Han Shuangze , Zhou Li , Liu Wenbin , Li Wei 
Published: November 2020

Abstract
Background

Aurora B kinase is aberrantly overexpressed in various tumors and shown to be a promising target for anti-cancer therapy.
Methods

A customized natural product library was used for natural compound screening through Molecular modeling. The expression of Aurora B in oral squamous cell carcinoma (OSCC) and the inhibitory effect of Tanshinone IIA (Tan IIA) on OSCC were examined by MTS and colony formation assays, immunoblot, immunofluorescence, immunohistochemical staining, and in vivo xenograft experiment.
Results

Aurora B is overexpressed in OSCC tumor tissues and cell lines. Knockdown of Aurora B inhibited the malignant phenotypes of OSCC cells in vitro and in vivo. With a molecular modeling screening of 74 commercially available natural products, we identified that Tan IIA, as a potential Aurora B kinase inhibitor. Tan IIA exhibited a significant anti-tumor effect on OSCC cells both in vitro and in vivo, including reduction of Aurora B and histone H3 phosphorylation, induction of G2/M cell cycle arrest, increase the population of polyploid cells, and promotion of apoptosis. The in vivo mouse model revealed that Tan IIA delayed tumor growth of OSCC cells. Tan IIA alone or in combination with radiation overcame radioresistance in OSCC xenograft tumors.
Conclusion

Our data indicates that targeting Aurora B kinase signaling is a promising anti-tumor strategy for OSCC treatment.
Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study
Authors: Liu Li , Cheng Bolun , Wen Yan , Jia Yumeng , Cheng Shiqiang , Liang Chujun , Chu Xiaomeng , Ye Jing , Yao Yao , Dai Xiaoxia , Guo Xiong , Zhang Feng 
Published: November 2020

Abstract
Background

We aim to explore the genetic association between hand grip strength (HGS) and gut microbiota (GM).
Methods

The genome-wide association study (GWAS) data of GM was obtained from a recently published study, involving 2,646 individuals. Phenotypic data of left HGS (n = 375,229) and right HGS (n = 375,279) were derived from the UK Biobank. Firstly, PLINK 2.0 was used to calculate 114 GM related polygenetic risk score (PRS) of each subject based on GWAS result. Regression analysis was then conducted to evaluate the possible association of GM-PRS and HGS. Then genome-wide by environment interaction study (GWEIS) of GM related traits was then performed using a regression model adjusted for age, gender, BMI and 10 principal components.
Results

For PRS analysis, 13 candidate GM were identified to be associated with left HGS (P < 0.05), including G_Bifidobacterium (P = 8.36 × 10− 4), G_Clostridium_sensu_stricto (P = 2.69 × 10− 3), and 10 significant GM for right HGS, such as G_Acidaminococcus (P = 1.29 × 10− 2), G_Streptococcus (P = 1.79 × 10− 2). In addition, 4 GM were found to be overlapped in association with both left and right HGS, including G_Bifidobacterium (P right HGS = 2.78 × 10− 2, P left HGS = 8.36 × 10− 4). Furthermore, several genome-wide significant GWEIS associations were detected for HGS, including 3 significant SNPs interacted with G_Butyricicoccus (P < 5 × 10− 8) for right HGS (rs41310432, P = 3.86 × 10− 8; closest gene: NASP; rs1053941, P = 4.71 × 10− 8; closest gene: NASP; rs6671239, P = 4.73 × 10− 8, closest gene: GPBP1L1), and 1 suggestive intronic SNP in CACNA1H on chromosome 16 interacted with G_Butyricicoccus (rs139206507, P = 8.68 × 10− 8 ) for left HGS.
Conclusions

Our study holds great potential gaining a better understanding of the relationship between GM and HGS.
Cerebral Venous Sinus Thrombosis Associated with COVID-19: A Case Series and Literature Review
Authors: Ostovan Vahid Reza , Foroughi Razieh , Rostami Mahtab , Almasi-Dooghaee Mostafa , Esmaili Manouchehr , Bidaki Ali Akbar , Behzadi Zahra , Farzadfard Farzane , Marbooti Hoda , Rahimi-Jaberi Abbas , Poursadeghfard Maryam , Fadakar Nima , Bayat Mahnaz , Owjfard Maryam , Salehi Mohammad Saied , Zafarmand Seyedeh Shaghayegh , Mardi Farzad , Safari Anahid , Shahjouei Shima , Mowla Ashkan , Azarpazhooh M Reza , Zand Ramin , Hooshmandi Etrat , Borhani-Haghighi Afshin 
Published: November 2020

Abstract
Background: Since the COVID-19 pandemic, several cases of cerebral venous sinus thrombosis (CVST) have been reported in SARS-CoV-2 infected individuals. This study provides a series of patients with CVST and SARS-CoV-2 infection.Methods: Consecutive patients with documented SARS-CoV-2 infection, as well as clinical and radiological characteristics of CVST, were reported from three teaching hospitals in the South West, North West, and the center of Iran from June to July 2020. We also searched the abstract archives until the end of August 2020 and gathered 28 reported cases. The diagnostic criteria for SARS-CoV-2 infection were determined according to SARS-CoV-2 detection in oropharyngeal or nasopharyngeal samples in clinically suspected patients. Demographics, main COVID-19 symptoms, confirmatory tests for SARS-CoV-2 infection diagnosis, the interval between the diagnosis of SARS-CoV-2 infection and CVST, clinical and radiological features of CVST, therapeutic strategies, CVST outcomes, rate of hemorrhagic transformation, and mortality rate were investigated.Results: Six patients (aged 31 to 62 years old) with confirmed CVST and SARS-CoV-2 infection were admitted to our centers. Four patients had no respiratory symptoms of SARS-CoV-2 infection. Five out of six patients developed the clinical manifestations of CVST and SARS-CoV-2 infection simultaneously. Three patients had known predisposing factors for CVST. Despite receiving CVST and SARS-CoV-2 infection treatments, four out of six patients passed away.Conclusions: The role of SARS-CoV-2 as a “cause” versus an “additive contributor” remains to be elucidated. Practitioners should be aware of the possibility of CVST in SARS-CoV-2 infection.
Clinical effect of minimally invasive surgery for inguinal cryptorchidism
Authors: Wang Yunjin , Chen Liu , Cui Xu , Zhou Chaoming , Zhou Qing , zhang zhengmian 
Published: November 2020

Abstract
Background: The purpose of this study was to investigate the clinical effect of minimally invasive surgery for inguinal cryptorchidism.Methods: The patients were divided into the minimally invasive surgery group (n=100) and the traditional surgery group (n=58). In the minimally invasive surgery group, patients with low inguinal cryptorchidism (n=54) underwent surgery with a transscrotal incision, and patients with high inguinal cryptorchidism (n=46) underwent laparoscopic surgery. Results: There was no difference in the hospital stay duration or cost between the minimally invasive surgery group and the traditional surgery group (P>0.05). As for the operative time, minimally invasive surgery of low inguinal cryptorchidism was shorter than traditional surgery (P=0.033), while minimally invasive surgery of high inguinal cryptorchidism was comparable to traditional surgery (P=0.658). Additionally, there were no cases of testicular atrophy, testicular retraction, inguinal hernia or hydrocele in either group. There was no significant difference in the incidence of poor wound healing between the two groups (P>0.05). Although there was no significant difference in the incidence of scrotal hematoma between the two groups (P>0.05), the incidence in the minimally invasive surgery group was higher than that in the traditional surgery group. Conclusions: Minimally invasive surgery including a transscrotal incision for low inguinal cryptorchidism and laparoscopic surgery for high inguinal cryptorchidism is as safe and effective as traditional surgery, and could also provide a good cosmetic effect for children.
The association between self-management ability and malnutrition-inflammation-atherosclerosis syndrome in peritoneal dialysis patients: A cross-sectional study
Authors: Huang Zehui , Fang Junyan , Song Ahui , Tong Yan , Deng Hai , Wei Shan , Ji Ouyang , Hu Chun , Li Pu , Zhang Chunli , Liu Yingli 
Published: November 2020

Abstract
BackgroundThe relationship between malnutrition-inflammation-atherosclerosis syndrome (MIAS) and self-management ability has not been previously revealed even though both play an important role in the management of peritoneal dialysis (PD) patients.MethodsIn total, 93 patients were enrolled in this study. A self-management questionnaire was used for the evaluation of self-management ability. The identification of MIAS was based on one or more of the following three conditions: C-reactive protein (CRP) ≥10 mg/L, malnutrition–inflammation score (MIS) >7, and the presence of atherosclerosis-related medical records. The possible association between different self-management abilities and MIAS was analyzed with a Spearman correlation analysis.ResultsThere were 40 (43.0%) patients in the atherosclerosis group, and 38 (40.9%), 38 (40.9%), 10 (10.8%), and 7 (7.5%) patients in the MIAS0, MIAS1, MIAS2, and MIAS3 groups, respectively. The group with a score above the mean score of the Dialysis Effect Evaluation and Monitoring dimension had a fewer number of hospitalizations, higher albumin levels, lower MIS scores, a lower level of IL-6, and a lower number of MIAS factors. The Pearson and Spearman correlation analyses also revealed that this dimension was negatively correlated with the MIAS, MIS, IL-6, BNP, number of hospitalizations, and age and positively associated with albumin and prealbumin. ConclusionThe Dialysis Effect Evaluation and Monitoring dimension of the self-management scale for PD patients is closely linked to the MIAS, and a better dialysis effect evaluation and monitoring capacity results in a decreased likelihood of exposure to malnutrition and inflammation.Trial registrationChinese Clinical Trial Registry: SH9H-2020-T20-2, retrospectively registered January 15, 2020.
Chip-Less and Battery-Less Subharmonic Tags for Wireless Sensing with Parametrically Enhanced Sensitivities and Dynamic Ranges
Authors: Hussein Hussein , Rinaldi Matteo , Onabajo Marvin , Cassella Cristian 
Published: November 2020

Abstract
Massive deployments of wireless sensor nodes (WSNs) that continuously detect physical, biological or chemical parameters are needed to truly benefit from the unprecedented possibilities opened by the Internet-of-Things (IoT). Just recently, new sensors with higher sensitivities have been demonstrated by leveraging advanced on-chip designs and microfabrication processes. Yet, WSNs using such sensors require energy to transmit the sensed information. Consequently, they either contain batteries that need to be periodically replaced or energy harvesting circuits whose low efficiencies prevent a frequent and continuous sensing and impact the maximum range of communication. Here, we report a new chip-less and battery-less tag-based WSN that fundamentally breaks any previous paradigm. This WSN, formed by off-the-shelf lumped components on a printed substrate, can sense and transmit information without any need of supplied or harvested DC power, while enabling full-duplex transceiver designs for interrogating nodes rendering them immune to their own self-interference. Also, even though the reported WSN does not require any advanced and expensive manufacturing, its unique parametric dynamical behavior enables extraordinary sensitivities and dynamic ranges that can even surpass those achieved by on-chip sensors. The operation and performance of the first implementation of this new WSN are reported. This device operates in the Ultra-High-Frequency range and is capable to passively and continuously detect temperature changes remotely from an interrogating node.