bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stitch in the ditch: Nutzotin Mountains (Alaska) fluvial strata and a dike record ca. 117–114 Ma accretion of Wrangellia with western North America and initiation of the Totschunda fault
Authors: Trop Jeffrey M. , Benowitz Jeffrey A. , Koepp Donald Q. , Sunderlin David , Brueseke Matthew E. , Layer Paul W. , Fitzgerald Paul G. 
Published: November 2019

AbstractThe Nutzotin basin of eastern Alaska consists of Upper Jurassic through Lower Cretaceous siliciclastic sedimentary and volcanic rocks that depositionally overlie the inboard margin of Wrangellia, an accreted oceanic plateau. We present igneous geochronologic data from volcanic rocks and detrital geochronologic and paleontological data from nonmarine sedimentary strata that provide constraints on the timing of deposition and sediment provenance. We also report geochronologic data from a dike injected into the Totschunda fault zone, which provides constraints on the timing of intra–suture zone basinal deformation. The Beaver Lake formation is an important sedimentary succession in the northwestern Cordillera because it provides an exceptionally rare stratigraphic record of the transition from marine to nonmarine depositional conditions along the inboard margin of the Insular terranes during mid-Cretaceous time. Conglomerate, volcanic-lithic sandstone, and carbonaceous mudstone/shale accumulated in fluvial channel-bar complexes and vegetated overbank areas, as evidenced by lithofacies data, the terrestrial nature of recovered kerogen and palynomorph assemblages, and terrestrial macrofossil remains of ferns and conifers. Sediment was eroded mainly from proximal sources of upper Jurassic to lower Cretaceous igneous rocks, given the dominance of detrital zircon and amphibole grains of that age, plus conglomerate with chiefly volcanic and plutonic clasts. Deposition was occurring by ca. 117 Ma and ceased by ca. 98 Ma, judging from palynomorphs, the youngest detrital ages, and ages of crosscutting intrusions and underlying lavas of the Chisana Formation. Following deposition, the basin fill was deformed, partly eroded, and displaced laterally by dextral displacement along the Totschunda fault, which bisects the Nutzotin basin. The Totschunda fault initiated by ca. 114 Ma, as constrained by the injection of an alkali feldspar syenite dike into the Totschunda fault zone.These results support previous interpretations that upper Jurassic to lower Cretaceous strata in the Nutzotin basin accumulated along the inboard margin of Wrangellia in a marine basin that was deformed during mid-Cretaceous time. The shift to terrestrial sedimentation overlapped with crustal-scale intrabasinal deformation of Wrangellia, based on previous studies along the Lost Creek fault and our new data from the Totschunda fault. Together, the geologic evidence for shortening and terrestrial deposition is interpreted to reflect accretion/suturing of the Insular terranes against inboard terranes. Our results also constrain the age of previously reported dinosaur footprints to ca. 117 Ma to ca. 98 Ma, which represent the only dinosaur fossils reported from eastern Alaska.
Osler Centenary Papers: Osler as medical leader
Authors: Singer Donald R J 
Published: November 2019

AbstractThe Canadian physician Sir William Osler is a key figure in the history of modern medicine. He encouraged lifelong learning for doctors, starting with bedside teaching. Contemporary with Old World figures such as Pasteur in Paris and Virchow in Berlin, he played a major role in raising awareness among clinicians of the importance of the scientific basis for the practice of medicine. He championed a rational approach to treatment and did much to encourage avoidance of ‘unnecessary drugging’ by prescribers. He is credited with playing a key role in improving education of medical students and postgraduate education of doctors, with important benefits for the care of hospital patients. He also had a major influence on his medical colleagues through founding and leading medical societies. A century on from his death in December 1919, his specific contributions and how he achieved them are not well known. The aim of this article is to consider the evidence that Osler was an influential medical leader and to reflect on the extent to which the achievements which resulted from his leadership are relevant to modern clinical medicine. Questions of interest include his leadership style, what made for his success as a leader, his medical achievements both in North America and in England, his own insight into leadership and how he was viewed by his peers.
СТРУКТУРНО-ПРОСТОРОВЕ РЕМОДЕЛЮВАННЯ СУДИННОГО РУСЛА ЗАДНІХ КІНЦІВОК ЩУРІВ ПРИ ГОСТРІЙ ІШЕМІЇ
Authors: Televiak A. T. , Selskyy P. R. , Herman O. M. , Yushchak M. V. , Selskyy B. P. 
Published: November 2019

Мета роботи. Встановити особливості структурно-просторового ремоделювання артерій задніх кінцівок щурів при гострій ішемії, спричиненій накладанням артеріального джгута, та наступній реперфузії.
Матеріали і методи. Проведено рентгенангіографічне та морфометричне дослідження артеріальних судин задніх кінцівок 30 щурів за умов експериментальної гострої ішемії. У контрольній групі було 6 інтактних тварин. Гостру ішемію спричиняли шляхом накладання гумових джгутів SWAT шириною 5–6 мм на задні кінцівки тварин, на рівні пахвинної складки протягом 2 год під тіопенталовим знеболюванням, а реперфузію моделювали шляхом зняття турнікета.
Просторову організацію артерій вивчали у судинних розгалуженнях (трійниках): у стегновій ділянці – в місці роздвоєння м’язової гілки, у підколінній ділянці – в місці біфуркації м’язової краніальної гілки, а в гомілковій – у місці поділу підколінної артерії на краніальну та каудальну великогомілкові артерії. У судинному трійнику вимірювали діаметри основного стовбура, товстішої і тоншої артеріальних гілок, сумарний кут галуження артерій та його складові частини – кут відхилення товстішої і тоншої гілок.
Результати й обговорення. Результати морфометричних досліджень встановили структурно-просторове ремоделювання артеріального русла задніх кінцівок щурів у стегновій, підколінній та гомілковій ділянках кінцівки нижче місця накладання артеріального турнікета. В артеріальних трійниках вказаних ділянок кінцівки виявлено збільшення пересічного діаметра основних стовбурів артерій, яке досягало максимуму через 1 добу експерименту. Так, максимальне зростання діаметра основного стовбура трійника в стегновій ділянці становило 13,11 %, у підколінній ділянці – 13,95 %, а в гомілковій – 14,99 % (для всіх р<0,05) порівняно з групою контролю. При цьому збільшувався діаметр як товстішої, так і (більшою мірою) тоншої трійникової гілки. Одночасно виявлено збільшення загального кута галуження дочірніх гілок в стегновій ділянці на 9,02 %, в підколінній ділянці – на 8,89 %, а у гомілковій – на 6,36 % порівняно з групою контролю (для всіх р<0,05), більшою мірою унаслідок збільшення відхилення тоншої гілки. Через 14 діб реперфузії морфометричні показники повертались до рівня значень контрольної групи.
Висновки. Результати рентгенангіографічного та морфометричного досліджень підтверджують ремоделювання артерій задніх кінцівок щурів у результаті розвитку в дослідних тварин ішемічно-реперфузійного синдрому, яке проявлялося збільшенням пересічного діаметра основних стовбурів артерій судинних трійників та збільшенням кута галуження дочірніх гілок. При цьому виявлено збільшенням діаметрів і кутів відхилення як товстішої, так і (більшою мірою) тоншої трійникової гілки.
Malay Women Leaders in Malaysia: The Unthinkable?
Authors: Saat Norshahril 
Published: November 2019

Abstract
This article examines the position of the Malay religious elite towards the idea of women as leaders. Based on an analysis of the writings and sermons of a sample of the religious elite, the article concludes that they continue to be of the view that gender roles in modern society are ‘fixed’, ‘divine’, and ‘unquestionable’. By exploring Mohammed Arkoun’s concept of the ‘unthinkable’, I argue that the notion that women are unfit for top political leadership positions, by virtue of their gender, results from a parochial attitude towards traditions relating to women’s role in society and from a general failure to re-evaluate traditions in the light of the modern-day context. By traditions here, I refer not only to the hadiths (recorded sayings of the Prophet Mohammad), but also compilations of Qurʾanic exegesis (tafsīr) and juristic opinions (fatāwā, s. fatwa) passed down from one generation to another in the last 1,400 years of Islamic history. The article also explores how the religious elite’s views of gender equality might be reformed—it suggests that they need to be challenged with alternative discourses in order to transform their attitude towards religious sources from one that is unquestioning to one that is more questioning.
Russia’s Strategy for Perception Management through Public Diplomacy and Influence Operations: The Canadian Case
Authors: Potter Evan H. 
Published: November 2019

Summary
This article argues that official Russian global media platforms such as Russia Today (RT) and Sputnik News, as well as Kremlin-friendly news outlets, represent the overt face of Russia’s global information ecology. The article discusses how such platforms fit into a framework for public diplomacy that has less-restrictive conceptual boundaries, and examines the intersection of public diplomacy with other dimensions of a nation-state’s operations for international influence. The article avers that a broader understanding of Russia’s international communication practices permits the inclusion of so-called ‘sharp’ practices as part of the strategic communications component of public diplomacy. It examines the case study of a Canadian foreign minister’s family history, illustrating Russia’s approach to international perception management through public diplomacy.
Biodiversity and chorology of aquatic beetles (Coleoptera: Elmidae and Hydraenidae) in Kabylia (central-north Algeria). New records and updates
Authors: LAMINE SMAIL , LOUNACI ABDELKADER , BENNAS NARD 
Published: November 2019

This work presents a list of water beetles of the families Hydraenidae and Elmidae occurring in Kabylia (central-north of Algeria) based on an exhaustive review of literature (1872–2016) and on more than 2126 individuals collected during field campaigns (2013–2015). Twenty-five species belonging to nine genera of Hydraenidae and Elmidae are here recorded from a total of 25 sites. Ochthebius (Ochthebius) bifoveolatus Waltl, 1835 is here recorded for the first time from Algeria; Hydraena leprieuri, Limnebius pilicauda, and Limnius intermedius are new records for Kabylia. A biogeographical analysis shows that the Hydraenidae and Elmidae from Kabylia are essentially Mediterranean (80%) and Palaearctic (20%) elements. Elements with wider distributions are absent.
Examining Biases in Diurnally Integrated Shortwave Irradiances due to Two- and Four-Stream Approximations in a Cloudy Atmosphere
Authors: Ham Seung-Hee , Kato Seiji , Rose Fred G. 
Published: November 2019

AbstractShortwave irradiance biases due to two- and four-stream approximations have been studied for the last couple of decades, but biases in estimating Earth’s radiation budget have not been examined in earlier studies. To quantify biases in diurnally averaged irradiances, we integrate the two- and four-stream biases using realistic diurnal variations of cloud properties from Clouds and the Earth’s Radiant Energy System (CERES) synoptic (SYN) hourly product. Three approximations are examined in this study: delta-two-stream-Eddington (D2strEdd), delta-two-stream-quadrature (D2strQuad), and delta-four-stream-quadrature (D4strQuad). Irradiances computed by the Discrete Ordinate Radiative Transfer model (DISORT) and Monte Carlo (MC) methods are used as references. The MC noises are further examined by comparing with DISORT results. When the biases are integrated with one day of solar zenith angle variation, regional biases of D2strEdd and D2strQuad reach up to 8 W m−2, while biases of D4strQuad reach up to 2 W m−2. When the biases are further averaged monthly or annually, regional biases of D2strEdd and D2strQuad can reach −1.5 W m−2 in SW top-of-atmosphere (TOA) upward irradiances and +3 W m−2 in surface downward irradiances. In contrast, regional biases of D4strQuad are within +0.9 for TOA irradiances and −1.2 W m−2 for surface irradiances. Except for polar regions, monthly and annual global mean biases are similar, suggesting that the biases are nearly independent to season. Biases in SW heating rate profiles are up to −0.008 K day−1 for D2strEdd and −0.016 K day−1 for D2strQuad, while the biases of the D4strQuad method are negligible.
Heuristic Evaluation of A Tesla Model 3 Interface
Authors: Parkhurst Eva L. , Conner Lindsay B. , Ferraro James C. , Navarro Mar E. , Mouloua Mustapha 
Published: November 2019

Usability research is important in our age of developing technology as it has significant implications for how technology is perceived by users. In 2017 Tesla released the Model 3, their most affordable electric-only vehicle to date. The vehicle is unique in its simplistic inner controls, composed of a single centralized touchscreen and instrumentation on the steering wheel. A heuristic analysis was conducted on the interface system of a Model 3 and several heuristic violations were identified. Suggestions to remedy the usability issues were provided along with considerations for future design of such interfaces.
Stronger than your voices: A cognitive behavioral therapy for youth suffering from auditory verbal hallucinations
Authors: Maijer Kim , Staring Tonnie , Bartels-Velthuis Agna A , Palmen Saskia JMC , Sommer Iris EC 
Published: November 2019

Objective: Auditory verbal hallucinations (AVHs) are a common feature in youth and mostly transient. Nevertheless, while present, AVH can cause considerable distress. Children and adolescents seeking help for distressing AVH represent a heterogeneous group in terms of underlying factors, yet they consistently suffer from their AVH. Until now, a youth-specific psychotherapeutic intervention for AVH was lacking. Experts in the field of treating AVH in both adults and youngsters collaborated with service users to develop the cognitive behavioral therapy (CBT) “Stronger Than Your Voices” (STYV). We investigated feasibility and clinical outcomes of the STYV therapy. Methods: Patients were derived from children and adolescents seeking help for AVH at the UMC Utrecht outpatient clinic with an indication for STYV therapy. Therapists preferably originated from referring health care facilities and were required to have sufficient general knowledge and experience with CBT. They received a short individual training to apply STYV. After, patients and their therapists could participate this naturalistic pilot study, assessing feasibility, tolerability, and clinical change when applying the STYV therapy. Results: Six participants (10–16 years old), all suffering from comorbid psychopathology, provided pre and post measures, all completing STYV therapy without experiencing an aggravation of symptoms. AVH total impact decreased 40% with Cohen’s d within-group effect size (1.28) also suggesting clinically meaningful change. Therapists were positive about STYV therapy and manual. Conclusion: The STYV therapy is feasible for youth with distressing AVH. First results indicate that STYV may be clinically effective. A trial to further test effectiveness in a larger sample is needed.
Treatment of High Risk Diffuse Large B-Cell Lymphomas (DLBCL) with Ntensive Induction Chemotherapy, Rituximab and Autologous Stem Cell Transplant.
Authors: Pytlik Robert , Trneny Marek , Belada David , Pirnos Jan , Kubackova Katerina , Jankovska Milada , Vasova Ingrid , Kozak Tomas , Pukyova Jana , Pribylova Jana , Siffnerova Hana , Zak Pavel , Hamouzova Michaela , Klener Pavel 
Published: November 2019

Abstract
Background. Aggressive lymphomas with high-intermediate to high risk according to IPI or age-adjusted IPI (aaIPI) have approximately 50% probability of disease progression in two years. Previous studies of CLSG have shown that intensive induction chemotherapy combined with high-dose chemotherapy and autologous stem cell transplant (ASCT) might be benefitial in these patients (Trneny, Blood98(11) 682a, 2001). In current study, we have explored the efficacy and tolerability of this regimen in combination with antiCD20 antibody rituximab (R) for DLBCL with 2 or 3 risk factors according to aaIPI.
Methods. DLBCL patients of age 18–65 years and aaIPI 2 or 3 were eligible for the study. Treatment protocol consisted of three cycles of high-dose CHOP (MegaCHOP, cytoxan 3 g/m2, doxorubicin 75 mg/m2, vincristin 2 mg, and prednison 300 mg/m2 every 21 days with G-CSF support), followed by three cycles of ESHAP and BEAM with ASCT. Peripheral progenitor cells were collected after first cycle of ESHAP. Four to six doses of R 375 mg/m2 were given on day 1 of induction chemotherapy. As four treatment-related deaths occured in first twenty patients, prephase consisting of AOP (MegaCHOP without cytoxan) was incorporated into the treatment regimen from mid-2003.
Results were analysed with intend-to treat approach. Kaplan-Meier curves were constructed for survival analyses. Results. 57 patients were treated from 2002–2004. Median age was 42 years (range, 21–64), and 34 patients were males (60%). 39 patients (67%) had aaIPI 2 and 18 patients (33%) had aaIPI 3. 17 patients had mediastinal variant of DLBCL (30%), and 40 patients (70%) had DLBCL-other. Of 54 evaluable patients, 47 achieved CR or CRu (87%), 5 achieved PR (9%) and two progressed less than three months after treatment completion (4%). Six patients died due to treatment related toxicity (11%), four of them treated without prephase. Three other patients have life-threathening complications (6%). Only one patient (2%) progressed more than one year after study entry. Both 2-year actuarial overall survival (OS) and 2-year event-free survival (EFS) are 79% after median follow-up of 13 months and are not different for aaIPI 2 or 3 patients.
Conclusion. Intensive induction chemotherapy combined with rituximab and ASCT is an effective strategy for treatment of young and high risk patients with CD20 positive DLBCLs. The two-year survival rates are higher than expected especially for aaIPI 3 patients. However, the toxicity is quite severe and the advantage of this regimen is to be proven in randomized trials.
Megakaryocytes Package and Deliver Golgi-Associated Glycosyltransferases into Platelets and to Platelet Surfaces Using Dense Granules.
Authors: Wandall Hans H. , Sørensen Anne Louise , Patel Sunita , Richardson Jennifer , Italiano Joseph E. , Rumjantseva Victoria , Bennett Eric P. , Clausen Henrik , Stossel Thomas P. , Hartwig John H. 
Published: November 2019

Abstract
We recently presented evidence for the presence of a β4 galactosyl transferase (β4GalT) on the surface of platelets that catalyzes the coupling of galactose in a β1,4 linkage to exposed N-acetylglucosamine residues on the N-linked glycans of GP1ba and that this reaction improved the circulation of chilled murine platelets. Since an externally-disposed glycosyltransferase activity contradicts the dogma that such enzymes reside solely within the Golgi apparatus, we verified it by demonstrating that intact platelets glycosylate 2.8 μm beads coated with the acceptor substrate GlcNAc-β-R. We then explored the origin of this enzyme in megakaryocytes and its mechanism of delivery to platelets. We report that Golgi marker GM130 as well as a YFP tagged Golgi marker construct based on the polypeptide transferase GalNAc-T2 expressed in cultured mouse megakaryocytes transports from the cell body of to nascent platelets in discrete packets. In immature megakaryocytes, the Golgi organizes, as expected, into perinuclear arrays. However, once proplatelet extension begins, the perinuclear apparatus disassembles, and Golgi-associated proteins transport through the proplatelets in vesicular/granular structures. Labeling with granule markers reveals correspondence of Golgi markers only with dense granules. These findings suggest that Golgi membrane becomes packaged into dense granules, which deliver Golgi-associated glycosyltransferases into the nascent platelets and from there to the platelet surface.
Studies on Analogues of L-Cysteine and L-Cystine
Authors: WEISBERGER AUSTIN S. , SUHRLAND LEIF G. , SEIFTER JOSEPH 
Published: November 2019

Abstract
The amino acids L-cysteine and L-cystine appear to have an important role in the metabolism of leukocytes. Decreased availability of these amino acids may therefore have important effects on leukocytes.
The possibility of decreasing the influx of radioactive L-cystine into leukemic leukocytes was investigated by exposing the leukocytes to various analogues of cysteine (cystine) prior to incubation with S35 L-cystine. It was found that a highly specific structural and spatial configuration is required to decrease the influx of S35 L-cystine. Thus unlabeled L-cysteine is effective in decreasing the incorporation of radioactive L-cystine. However, analogues of cystine in which there is modification or substitution of the sulfhydryl, amino or carboxyl group do not decrease the influx of S35 L-cystine. Furthermore, any alteration in the spatial relationship of the sulfhydryl and amino groups of L-cysteine also results in a loss of the ability of an analogue to decrease the incorporation of S35 L-cystine.
Of the compounds studied and in the concentrations employed, only unlabeled L-cysteine, selenium cystine and phenyl selenium cysteine were effective. Selenium cystine is identical with cystine except that selenium replaces the sulfur in the molecule. Phenyl selenium cysteine is also closely related structurally to cysteine.
The mechanism of action of selenium cystine and phenyl selenium cysteine in decreasing the influx of S35 L-cystine is not known. Other selenium compounds tested were ineffective. These compounds may exert their inhibitory effect by (a) competitive combination with specific intracellular receptors for L-cysteine (L-cystine), (b) inactivation of enzymes or compounds essential for normal cellular function, (c) alteration in membrane permeability or (d) a toxic effect of selenium.
Since selenium cystine and phenyl selenium cystine are inhibitory in low concentrations in vitro, these compounds may have important effects on leukemic leukocytes in vivo.
The Plasma Clearance and Urinary Excretion of Parenterally Administered 58Co B12
Authors: MOLLIN D. L. , PITNEY W. R. , BAKER S. J. , BRADLEY J. E. 
Published: November 2019

Abstract
Intravenous injections of 1.5 µg. of 58Co B12 were given to subjects with normal serum B12 concentrations, to patients with vitamin B12 deficiency and to patients with chronic myelocytic leukemia.
The rate of plasma clearance of radioactivity after this dose was slowest in patients with chronic myelocytic leukemia and patients with pernicious anemia in severe relapse.
In patients with vitamin B12 deficiency, serum B12 concentrations were estimated microbiologically at frequent intervals after the injection. There was a good correlation between the results obtained by microbiological assay and as calculated from plasma radioactivity.
Significant differences were not observed between the urinary excretion of radioactivity by normal subjects and patients with B12 deficiency.