bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of fetal echocardiography in morphologic and functional assessment of fetal heart in diabetic mothers
Authors: Raafat Mariam , Aborizk Sameh , Saraya Mahmoud , Soliman Hazem Hamed 
Published: May 2020

Abstract
Background
Diabetes mellitus (DM) is the commonest medical disorder faced during pregnancy and it includes type I, type II, and gestational diabetes. It may predispose to various complications including fetus malformation, macrosomia, spontaneous abortion, stillbirth, neonatal death, and intrauterine growth retardation. Hypertrophic cardiomyopathy (HCM) is one of the common anomalies depicted with diabetes. Fetal cardiac function analysis might provide important information on the hemodynamic status and cardiac adaptation to different perinatal complications.

Results
The mean septal thickness in the diabetic group was 0.7163 ± 0.1746 cm and 0.4989 ± 0.08068 cm in the control group. The mean myocardial thickness of the right ventricular free wall in the diabetic group was 0.6532 ± 0.13792 cm and 0.4874 ± 0.07482 cm in the control group. The mean myocardial thickness of the left ventricular free wall in the diabetic group was 0.6437 ± 0.13421 cm and 0.4737 ± 0.07573 cm in the control group. The mean value of myocardial performance index (Tie Index) in the diabetic group was 0.6232 ± 0.15606 and 0.4626 ± 0.04357 in the control group.

Conclusion
From our study, we can conclude that prenatal complete echocardiographic study should be mandatory in fetuses of diabetic mothers due to high risk of congenital heart defects and onset of hypertrophic cardiomyopathy with fetal cardiac function impairment in the third trimester.
Early diagnosis of congenital heart defects as well as evidence of hypertrophic cardiomyopathy and fetal cardiac function impairment that occurs in fetuses of maternal diabetes will definitely guide prompt postnatal therapy and care for those neonates.
Visualizing implementation: contextual and organizational support mapping of stakeholders (COSMOS)
Authors: Bernstein Steven L. , Weiss June , Curry Leslie 
Published: May 2020

Abstract
Background
While stakeholder mapping is common in public policy, social sciences, and business management, this tool has not often been used in healthcare settings. We developed a new method of healthcare stakeholder mapping, which we call Contextual and Organizational Support Mapping of Stakeholders (COSMOS), to identify and assess key stakeholders in an implementation project. Stakeholder mapping allows the implementation team to assess and visually display all relevant stakeholders, their support for the project, and their ability to facilitate—or hinder—project implementation.

Methods
The COSMOS model was developed to visualize the stakeholders involved in a hospital-based study conducted from 2013–2016. In this study, a new screen prompt and order set were embedded in the electronic health record to facilitate the identification and treatment of adult smokers admitted to the hospital. Physicians were the unit of randomization; physician behavior and tobacco quit rates among patients were followed for 1 year. Qualitative interviews with hospital administration, physicians, and information technology (IT) personnel (n=24) were conducted to identify the components and characteristics of the COSMOS.

Results
The COSMOS consists of an organizational chart identifying all key stakeholders, with manipulation of colors and borders of the component boxes to indicate stakeholder support for the implementation project, and degree of criticality to its success. The COSMOS visualization informed the team’s subsequent work by identifying potential impediments that might require additional attention to garner and maintain support throughout the project. In addition, the approach has proved to be a useful tool to explain these concepts to trainees in implementation science.

Conclusion
The COSMOS schematic provides a visually rich means of identifying stakeholders, understanding their relationships to each other, displaying their level of support for the proposed implementation, and noting their criticality to the effort. The COSMOS can support researchers, project teams, administrators, and others engaged with implementation science-related work in healthcare, as well as other fields such as education, government, and industry.
Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in a Drosophila model of renal fibrosis
Authors: Zheng Wenjing , Ocorr Karen , Tatar Marc 
Published: May 2020

ABSTRACT
Aldosterone is produced by the mammalian adrenal cortex to modulate blood pressure and fluid balance; however, excessive, prolonged aldosterone promotes fibrosis and kidney failure. How aldosterone triggers disease may involve actions independent of its canonical mineralocorticoid receptor. Here, we present a Drosophila model of renal pathology caused by excess extracellular matrix formation, stimulated by exogenous aldosterone and by insect ecdysone. Chronic administration of aldosterone or ecdysone induces expression and accumulation of collagen-like Pericardin in adult nephrocytes – podocyte-like cells that filter circulating hemolymph. Excess Pericardin deposition disrupts nephrocyte (glomerular) filtration and causes proteinuria in Drosophila, hallmarks of mammalian kidney failure. Steroid-induced Pericardin production arises from cardiomyocytes associated with nephrocytes, potentially reflecting an analogous role of mammalian myofibroblasts in fibrotic disease. Remarkably, the canonical ecdysteroid nuclear hormone receptor, Ecdysone receptor (EcR), is not required for aldosterone or ecdysone to stimulate Pericardin production or associated renal pathology. Instead, these hormones require a cardiomyocyte-associated G-protein-coupled receptor, Dopamine-EcR (DopEcR), a membrane-associated receptor previously characterized in the fly brain to affect behavior. DopEcR in the brain is known to affect behavior through interactions with the Drosophila Epidermal growth factor receptor (Egfr), referred to as dEGFR. Here, we find that the steroids ecdysone and aldosterone require dEGFR in cardiomyocytes to induce fibrosis of the cardiac-renal system. In addition, endogenous ecdysone that becomes elevated with age is found to foster age-associated fibrosis, and to require both cardiomyocyte DopEcR and dEGFR. This Drosophila renal disease model reveals a novel signaling pathway through which steroids may modulate mammalian fibrosis through potential orthologs of DopEcR.
Frameshift mutations of YPEL3 alter the sensory circuit function in Drosophila
Authors: Kim Jung Hwan , Singh Monika , Pan Geng , Lopez Adrian , Zito Nicholas , Bosse Benjamin , Ye Bing 
Published: May 2020

ABSTRACT
A frameshift mutation in Yippee-like (YPEL) 3 was recently found from a rare human disorder with peripheral neurological conditions including hypotonia and areflexia. The YPEL gene family is highly conserved from yeast to human, but its members’ functions are poorly defined. Moreover, the pathogenicity of the human YPEL3 variant is completely unknown. We generated a Drosophila model of human YPEL3 variant and a genetic null allele of Drosophila homolog of YPEL3 (referred to as dYPEL3). Gene-trap analysis suggests that dYPEL3 is predominantly expressed in subsets of neurons, including larval nociceptors. Analysis of chemical nociception induced by allyl-isothiocyanate (AITC), a natural chemical stimulant, revealed reduced nociceptive responses in both dYPEL3 frameshift and null mutants. Subsequent circuit analysis showed reduced activation of second-order neurons (SONs) in the pathway without affecting nociceptor activation upon AITC treatment. Although the gross axonal and dendritic development of nociceptors was unaffected, the synaptic contact between nociceptors and SONs was decreased by the dYPEL3 mutations. Furthermore, expressing dYPEL3 in larval nociceptors rescued the behavioral deficit in dYPEL3 frameshift mutants, suggesting a presynaptic origin of the deficit. Together, these findings suggest that the frameshift mutation results in YPEL3 loss of function and may cause neurological conditions by weakening synaptic connections through presynaptic mechanisms.
Fascia lata attachment at the iliac crest: refining our diagnostic criteria of injury on magnetic resonance imaging
Authors: Serhal Ali , Adams Bradley , Omar Imarn , Deshmukh Swati 
Published: May 2020

Objective:
The objective of this study was to determine the prevalence and spectrum of pathology of the fascia lata attachment at the iliac crest (FLAIC) on MRI in asymptomatic patients in order to refine our diagnostic criteria for clinically relevant FLAIC injury.

Methods and material:
Two readers retrospectively evaluated the FLAIC on each side on coronal large field-of-view short tau inversion recovery images on 100 musculoskeletal pelvic MRI exams performed in patients without hip pain (total n = 200). Pathology of the FLAIC was graded using a 3-point Likert scale and discrepancies were resolved by consensus.

Results:
Of the 200 FLAIC included in the study, 72.5% demonstrated normal size and signal intensity. Low to moderate grade pathology of the FLAIC was identified in 27% and high-grade partial thickness pathology was seen in 0.5%. No cases of complete FLAIC rupture were identified. Inter rater agreement between the two readers was good (k=0.660, p &lt; 0.001). There was no statistical difference in FLAIC scores according to gender or age. FLAIC score was positively correlated with higher body mass index.

Conclusion:
Incidental low to moderate grade FLAIC pathology is commonly seen on MRI in asymptomatic patients. Abnormal MRI findings of the FLAIC should hence be correlated with explicit clinical symptoms and physical exam findings.

Advances in knowledge:
The Fascia lata is a complex anatomic structure. Its attachment to the iliac crest is an under recognized pathology and sometimes overlooked during evaluation for pelvis and lateral hip pain. Evaluation of the FLAIC is easily done with MRI and abnormality should be correlated to the clinical symptomatology as low grade abnormality is frequently seen in asymptomatic population.
Neighbourhood Circles: The Study of Urban Neighbourhood in Contemporary Poland and Its Basic Outcomes
Authors: Nowak Marek , Pluciński Przemysław , Siatkowski Andrzej 
Published: May 2020

The article presents the problems of urban neighbourhood organized regarding its theoretical and empirical nature. It presents both the history and the theoretical discussion of neighbourhood research,especially within the frames of Polish sociology, although not exclusively, as well as empirical results of the latest research conducted in three cities of different size (Warsaw, Poznań, Wronki) in 2019. Partial results of the research presented in the article focus on factors conducive to building neighbourly relations.
Marek Nowak, Przemysław Pluciński, Andrzej Siatkowski, Neighbourhood Circles: The Study of Urban Neighbourhood in Contemporary Poland and Its Basic Outcomes [Kręgi sąsiedzkie: studium miejskiego sąsiedztwa we współczesnej Polsce, główne ustalenia] edited by M. Nowak, “Człowiek i Społeczeństwo” vol. XLVIII: Kuchnia badań miejskich. Studia na temat praktyki empirycznej badaczy miasta [A backstage of urban research], Poznań 2019, pp. 55–73, Adam Mickiewicz University. ISSN 0239-3271.
Marek Nowak, Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Socjologii, ul. Szamarzewskiego 89, 60-568 Poznań, e-mail: marek.nowak@amu.edu.plPrzemysław Pluciński, Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Socjologii, ul. Szamarzewskiego 89, 60-568 Poznań, e-mail: plucin@amu.edu.plAndrzej Siatkowski, Centrum Badań Społecznych Fundacji UAM, ul. Szamarzewskiego 89, 60-568 Poznań, e-mail: andrzej.siatkowski@amu.edu.pl
Onkológiai beteg tervezett PET/CT vizsgálata során véletlenszerűen felfedezett COVID–19-betegség.
Authors: Czibor Sándor , Kristóf Emese , Kecskés Kinga , Barra Magdolna , Szántó Péter , Maurovich-Horvat Pál , Györke Tamás 
Published: May 2020

Absztrakt:
A koronavírus-betegség 2019 (COVID–19) szakmai irodalma meglehetős gyorsasággal
bővül. Adatok jelzik, hogy sokszor nagy az ellentmondás egy-egy beteg esetében a
klinikai kép és a radiológiai lelet súlyossága között. Esetismertetésünk egy
tünetszegény beteg viszonylag súlyosabb radiológiai leleteit részletezi. Az
onkológiai alapbetegségben szenvedő, 75 éves nőbetegnél a tervezett, onkológiai
indikációval végzett F18-fluoro-dezoxi-glükóz pozitronemissziós
tomográfia/komputertomográfia vizsgálat során a tüdőkben incidentálisan
COVID–19-re utaló radiomorfológiai jeleket azonosítottunk. Azonnali izolációt
követően a beteget a megfelelő osztályra helyeztük át, ahol a további
vizsgálatok megerősítették a COVID–19 kórisméjét. Esetünk arra hívja fel a
figyelmet, hogy járványügyi veszélyhelyzet idején az esendő betegek (magas
életkorú, onkológiai betegségben szenvedők) tervezett képalkotó vizsgálata során
az elkészült mellkas-CT azonnali kiértékelésének nagy a jelentősége, mert így
időben azonosíthatunk a COVID–19 esetleges jelenlétére utaló radiomorfológiai
eltéréseket, amelyek alapvetően meghatározzák az aktuális további teendőket. Orv
Hetil. 2020; 161(23): 971–976.
When Source and Path Components Trade-Off in Ground-Motion Prediction Equations
Authors: Baltay Annemarie S. , Abrahams Lauren S. , Hanks Thomas C. 
Published: May 2020

AbstractCurrent research on ground-motion models (also known as ground-motion prediction equations [GMPEs]) and their uncertainties focus on the separate contributions of source, path, and site to both median values and their variability. Implicit here is the assumption that the event term, path term, and site term reflect only properties of the source, path, and site, respectively. Events with larger stress drop generate more high-frequency energy, and thus more ground motion. Therefore, the correlation of high-frequency (i.e., peak ground acceleration [PGA] or peak ground velocity [PGV]) event terms in GMPEs with stress drop is taken to be genuine. However, PGA and PGV ground-motion observations of the 2014 M 6.0 South Napa, California, earthquake clearly violate these assumptions. For this earthquake, high-frequency ground-motion residuals of recorded ground motion with respect to Next Generation Attenuation-West2 Project (NGA-West2) ground-motion models show a dependence on distance, biasing the calculation of the event term by incorrectly mapping a regional attenuation effect into it. We examine the trade-off between source and path effects for the South Napa earthquake and a well-recorded California subset of the NGA-West2 data. We fit near-source (i.e., within 20 or 50 km) event terms and remaining differential geometrical spreading and anelastic attenuation terms in comparison to a simultaneous inversion for the source and path terms. This South Napa instance highlights one situation for which the high-frequency event term can be interpreted as relative stress drop only when the distance dependence of the ground motions does not bias the residuals.
Closed loop small bowel obstruction due to mid urethral sling mesh
Authors: Alaoudi Marwan , Devanabanda Bhavana , Haj Roland , Louis Martine , Shah Darshak 
Published: May 2020

Closed loop small bowel obstruction is a surgical emergency, which when left untreated leads to vascular compromise resulting in intestinal ischemia, necrosis and perforation. We report the case of a 61 years old female with past surgical history of hysterectomy and a mid-urethral sling, who presented to the emergency department for abdominal pain and obstipation. She was found on imaging to have a closed loop small bowel obstruction. An exploratory laparotomy revealed an adhesive band encompassing the distal terminal ileum, visceral peritoneum and the Mid‐urethral slings mesh. This is a rare complication that, to our knowledge, has not been reported in the surgical literature. This paper will discuss the clinical presentation, diagnostic studies, therapeutic intervention and outcome of this unique case.
Comparison of shear bond strength as affected by ozonated water, fluoride varnish & casein phosphopeptide – Amorphous calcium phosphate
Authors: Mathew Jejo , R Kumar Reena 
Published: May 2020

A translatory research to validate antimicrobial and re-mineralization agents to reduce white spot lesions which would not unfavorably affect shear bond strength and focus on ozonated water being a valid and relatively inexpensive method for orthodontic patients to follow as a home follow up care.Tooth surfaces of 60 Extracted Human Premolar Teeth were cleaned and divided into four groups of 20 each and then treated with fluoride varnish, CPP-ACP, Ozonated water and distilled water before bonding brackets and later subjected to SBS testing. SBS of teeth treated with Ozone water and CPP-ACP were close to ideal SBS. Ozone water is a valid and relatively inexpensive method for orthodontic patients to follow as a home follow up care.
Prevalence of dental malocclusion in stomatology hospital, Kabul-Afghanistan
Authors: Erfan Ozair , Khan Manizha , Nadir Sina Mohammad 
Published: May 2020

The objective of this study was to determine the incidence of different types of malocclusion among 1000 OPD patients in Stomatology Hospital, Kabul, Afghanistan. 1000 patients between ages of 15-30 years (500 males and 500 females), randomly selected using specific criteria among patients that visited Kabul Stomatology Hospital OPD department, for 7 months. Patients were examined directly intra-orally, and information was collected by a single observer, recorded on pre-prepared forms, and analyzed through the SPSS program. Result of this study showed that from 1000 OPD patients, 81.2% were suffering from malocclusions, among which Class I Malocclusion was recorded to be 49%, Class II Division 1 was 14.8%, Class II Division 2 was 8.2%, Pseudo Class III was 3.1%, and Class III Malocclusion was recorded to be 6%. Class I Malocclusion was the most prevalent.
THE IMPACT OF HUMAN RESOURCE MANAGEMENT ON THE ACTIVITIES OF NON-GOVERNMENTAL ORGANIZATIONS USING STATISTICAL APPROACHES
Authors: Vasyaev Alexander , Ryzhova Yulia , Stovolos Nadiya , Belova Lyudmila 
Published: May 2020

Purpose of the study: The purpose of the study is to detect and track the possible correlation between the activities of non-governmental organizations and human resource management. This study also goal to investigate the role of the manager in fulfilling the prerequisites to reach the prosperity and flourishment within a group that works on a certain end.
Methodology: To achieve the objectives of the study, a survey of the management and employees of six non-governmental organizations operating in various fields (educational, sports, charitable, scientific) was conducted. A total of 150 people were interviewed. The Pearson chi-squared test was used to calculate preliminary approaches that are recently using and final findings.
Main Findings: The pilot analysis using the Pearson chi-squared method revealed that the personnel policy can have a positive effect on the organization, as it allows hiring qualified employees and promotes employee motivation. According to Pearson's chi-square criterion, it was found out that there is no statistically important relationship between human resource management and the operation of non-governmental organizations.
Applications of this study: This may be explained by the fact that there are other significant factors affecting the operation of the company and being involved in the human resource management policy. However, a competent personnel policy is one of the components of the successful development of the company.
Novelty/Originality of this study: The originality of this study is that this revealed that organizations should have clear requirements for their employees in order to hire them in accordance with the company criteria. In addition, it is necessary to create a favorable working environment, as well as to consider human resource management when setting the development priorities of the organization.
Ropivacaine 75mg versus placebo in perineal infiltration for analgesic efficacy at mid- and long-term for episiotomy repair in postpartum women- The ROPISIO study: a two-center, randomized, double-blind, placebo-controlled trial.
Authors: CARDAILLAC Claire , Ploteau Stéphane , Thuaut Aurélie Le , Dochez Vincent , Winer Norbert , Ducarme Guillaume 
Published: May 2020

Abstract
Background Perineal pain due to episiotomy is commonly reported and can be severe enough to disturb the mother-infant dyad during the postpartum period. Its incidence at day 7 postpartum varies from 63% to 74%. Recent studies have already investigated the analgesic efficacy of perineal infiltration of ropivacaine after episiotomy, but have only focused on the immediate postpartum period (at 24 and 48 hours after birth). Large, adequately powered, multicenter, randomized controlled trials are required to evaluate the impact of ropivacaine infiltration on perineal pain and mid- and long-term quality of life before the widespread use of ropivacaine to prevent perineal pain after episiotomy can be recommended. Methods The ROPISIO study is a two-center, randomized, double-blind, placebo-controlled trial in La Roche sur Yon and Nantes, France. It will involve 272 women with vaginal singleton delivery and mediolateral episiotomy at term (≥ 37 weeks). Perineal infiltration (ropivacaine 75mg or placebo) will be administrated just after vaginal birth and before episiotomy repair. The primary outcome will be the analgesic efficacy at day 7 postpartum (mid-term), defined by the numerical rating scale of pain (ENS NRS) strictly superior to 3/10 on the perineal repair area. Secondary outcomes will be the analgesic efficacy (ENS NRS), the impact of pain on daily behavior, on the quality of life (36-Item Short Form Health Survey), on the occurrence of symptoms of postpartum depression (Edinburgh Postnatal Depression Scale) and on sexuality (Female Sexual Function Index) at 3 and 6 months (long-term) using validated online questionnaires. This study will have 90% power to show approximately 30% relative risk reduction in the incidence of perineal pain at day 7, from 70.0% to 50.0%. Discussion Ropivacaine is a promising candidate drug, inexpensive, easy to administer, and would be suitable to include in the routine management of deliveries in labor ward. This study will investigate if perineal ropivacaine infiltration just after birth can reduce mid- and long-term postpartum pain and increase quality of life in women with mediolateral episiotomy.