bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the antimicrobial resistance patterns and MDR frequency in Escherichia coli strains isolated from clinical specimens taken from patients in Iran: 2017–2019
Authors: Bazgir Zahra Norouzi , Gholami Mehrdad , Goli Hamid Reza 
Published: September 2020

Abstract
Objectives The purpose of this study was to evaluate the antimicrobial resistance and frequency of MDR strains in E. coli isolated from patients in two hospitals of Iran. In this descriptive-analytical study, 13322 clinical specimens were collected from two teaching hospitals. The E. coli isolates were identified using standard bacteriological methods. Then, the resistance patterns of the isolates were analyzed by disk agar diffusion method according to the CLSI.Results Out of 13322 clinical samples, 964 (7.23%) isolates of E. coli were identified. In both hospitals, high resistance to ampicillin and cefalexin was presented in 621 (64.4%) and 402 (41.7%) isolates, respectively. The highest antibiotic resistance was observed in burn unit, burn ICU and burn restoration section, while all 8 strains which were isolated from the neonatal-ICU, were sensitive to all tested antibiotics except cefalexin, nitrofurantoin, nalidixic acid, and ampicillin. Also, the bacteria isolated from urine, wound, stool, and blood samples were resistant to all tested antibiotics. Increased resistance to different antibiotics in burn hospital has created increasing concern. Very high resistance to some antibiotics indicates that these drugs are misused in therapeutic centers and highlights that infection control measures should be arranged in the ICUs of our hospitals.
Thermodynamic analysis of dynamic processes in a centrifugal pump
Authors: Куликов А.А. , Смоляков А.Ф. , Иванова И.В. , Дюкова И.Н. 
Published: September 2020

Предложена термодинамическая и математическая модель процессов энер- гообмена в центробежном насосе. Для процесса повышения в насосе давления несжимаемой жидкости получено выражение. Из первого закона термодинамики выведена формула для КПД центробежного насоса. Построена физическая и математическая модель, позволяющие получить уравнение Эйлера для лопастных машин из первого закона термодинамики. Показано, что термодинамическая и математическая модели, примененные для лопастных машин, могут быть использованы для анализа процесса дросселирования.
The proposed thermodynamic and mathematical model of processes of energy exchange in a centrifugal pump. For the process of increasing the pump pressure of an incompressible fluid is obtained the expression. From the first law of thermodynamics the formula for the efficiency of centrifugal pump. A physical and mathematical model that allows to obtain the Euler equation for blade machines from the first law of thermodynamics. It is shown that the thermodynamic and mathematical models applied in kind for blade machines can be used for the analysis of process throttling.
The Role of Mitochondria in Piperine Mediated Cardioprotection in Isoproterenol Induced Myocardial Ischemia
Authors: Viswanadha Vijaya Padma , Dhivya Velumani , Somasundaram Bharath , Beeraka Narasimha Murthy , Huang Chih-Yang , Mikhaleva Liudmila M. , Achkasov Evgeny , Bondarev Sergey , Gridin Leonid , Nikolenko Vladimir N. , Aliev Gjumrakch 
Published: September 2020

Background:
Several pharmacological therapeutic interventions are being used as therapeutic agents
against myocardial infarction/ischemia (MI) but their usage is constrained by toxicity and nonselective pharmacological
actions. Our preliminary report depicted the cardioprotective effect of piperine against isoproterenol
(ISO)-induced MI.

Aim:
Current study determined the protective efficacy of piperine by modulating mitochondrial function in rat
models of isoproterenol (ISO)-induced myocardial ischemia.

Methods:
The above aim was achieved by analyzing mitochondrial antioxidant status, mitochondrial calcium,
mitochondrial enzyme activity, ATP level, and apoptosis. Ultra-structural alterations in heart tissue were determined
by TEM analysis. RT-PCR studies and Western blotting were executed to determine apoptotic and
proapoptotic gene expression, and apoptotic protein expression, respectively.

Results:
The results elucidate that piperine pre-treatment prevents ISO induced alterations in the mitochondrial
antioxidant status, Krebs cycle as well as mitochondrial respiratory chain enzyme activities (MRCEs). ISO induced
ultrastructural changes of heart mitochondria were significantly reduced in the group that received
piperine pretreatment followed by ISO injection. Piperine maintains mitochondrial calcium homeostasis and inhibits
ISO-induced myocardial apoptosis. A significant increase in the expression levels of proapoptotic genes
such as Bax, caspases (caspase 9, caspase 3), and cytochrome-c with a concomitant decrease in Bcl-2 expression
(anti-apoptotic gene) was observed in ISO injected group compared to the control group. The group that received
the piperine pretreatment followed by ISO administration showed a significant decrease in the expression
profile of proapoptotic genes with a concomitant increase in the anti-apoptotic gene expression than the
ISO injected group. Apoptotic protein expressions including Bax, cytochrome-c, caspase-3, and cleaved PARP
were upregulated & Bcl-2 was downregulated with ISO treatment, whereas piperine pre-treatment prevented these
changes in apoptotic protein expressions during ISO-induced myocardial cell damage.

Conclusion:
Current results demonstrate the efficacy of piperine for attenuating ISO-induced myocardial ischemia
by enhancing mitochondria function. This study described that piperine could be used as a nutritional intervention
against ISO-induced myocardial ischemia.
Withdrawal Notice: LC-UV Method for the Estimation of Drug Release from Carvacrol Loaded Nanobeads optimized by Response Surface Methodology
Authors: Talpada Pinal , Tandel Falguni 
Published: September 2020

The article has been withdrawn at the request of the authors and editor of the journal "Current Pharmaceutical Analysis."

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in the Azeri Population of Iran
Authors: Pourostadi Mahya , Sattarpour Simin , Poor Behroz M. , Asgharzadeh Mohammad , Kafil Hossein S. , Farhoudi Mehdi , Asgharzadeh Vahid , Vegari Ali , Najafi-Ghalelou Nima , Rashedi Jalil 
Published: September 2020

Background:
Multiple sclerosis (MS), a disease of the central nervous system (CNS), is
associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency
plays an important role in the development of the disease. Binding of vitamin D to its specific
nuclear receptors is a way to exert its function.

Objective:
Possible correlation between vitamin D receptor (VDR) gene and MS was evaluated in Azeri population of Iran.

Method:
Different genotypes of the Bsml site were determined by using the PCR-RFLP method in
148 MS patients and 220 non-relative healthy controls.

Results:
In MS patients, genotype bb was significantly higher than the healthy controls (p<0.05).
Additionally, most subjects of the MS group had been insufficiently exposed to sunlight before the
age of 15 (p<0.001). Our findings indicated that the red meat intake in MS patients was significantly
higher than the healthy controls (p<0.001). In addition, the healthy controls had appropriate dieting
behaviors in comparison to MS patients (excessive intake of some foods) (p=0.0001).

Conclusions:
In conclusion, genotype BB and sufficient exposure to sunlight before the age of 15
were the protective factors against MS. Although, excessive consumption of red meat and inappropriate
dieting behaviors were predisposing factors to MS disease.
An Iterative Power Regulation Technique in Emergency Cognitive Radio Network Based on Firefly Algorithm
Authors: Chatterjee Swagata Roy , Dhabal Supriya , Chakraborti Swati , Chakraborty Mohuya 
Published: September 2020

Background:
Manmade disasters like explosion, toxic wastes, chemical spills etc. have become an imperative
concern for our society. Manmade disasters are not everyday phenomenon. Thus, the allocation of separate resources is not
realistic. The idea is to use existing cellular infrastructure to implement single hop cognitive radio sensor network for
protecting human being from manmade disasters.

Objective:
The main objectives of this paper are as follows: (a) design of an efficient iterative power
regulation algorithm based on the Firefly Algorithm for the proposed network, (b) computation of
sensor nodes’ optimal power for different position of the cellular user from the base station assuming
that cellular user compromises power for its own sensor node, (c) computation of the maximum
number of sensor nodes coupled with single cellular user for different distances from the base station
in worst channel condition, and (d) comparative performance analysis with state-of-the-art algorithms.

Method:
In the presence of explosive and toxic gases, cognitive radio in sensor node establishes a
connection with the nearest base station to send pre-disaster alert signal utilizing cellular user’s resources.
The power is distributed among sensor nodes maintaining the fundamental requirements of
cellular users. Here, an iterative power regulation mechanism is employed for distributing the power
between sensor node and cellular user to achieve reliable utility of the network. The fitness function
is designed under the constraints of interference and the designed algorithm is implemented in
MATLAB platform towards the search of optimal power of sensor nodes by maximizing the fitness
function.

Results:
Comparative performance analysis demonstrates the effectiveness of the proposed algorithm
in terms of speed of convergence, the position of mobile phone user from the base station, number of
coupled sensor nodes with single cellular user, and Jain’s fairness factor.

Conclusion:
The proposed network controls the occurrence of manmade disasters and achieves reliable
transmission of emergency information prior to disaster without disrupting cellular phone users.
Simulation results validate that the proposed IPRFA algorithm outperforms with respect to state-ofthe-
art methods in terms of sharing power and Jain’s fairness factor.
SLS-catalyzed Multi-component One-pot Reactions for the Convenient Synthesis of Spiro[indoline-3,4’-pyrano [2,3-c]pyrazole] Derivatives
Authors: Dhakar Archana , Rajput Archana , Khanum Ghazala , Agarwal Dau D. 
Published: September 2020

Background and Objective:
Spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives are
an important heterocyclic compounds. These compounds shows wide range of biological properties
and exhibits varied pharmaceutical applications. Pyranopyrazoles, which are basically fused heterocyclic
compounds and act as vasodilators, hypertensive, hypoglycaemic and anticancer agents.

Methods:
An efficient and micelle-promoted surfactant catalyzed synthesis of spiro[indoline-
3,4′-pyrano[2,3-c]pyrazole] derivatives have been achieved via one-pot four-component reaction
of hydrazine hydrate (phenyl hydrazine), ethyl acetoacetate, malononitrile (ethyl cyanoacetate)
and isatin under thermal conditions (at 60°C) in water as a solvent.

Results:
Sodium lauryl sulphate (SLS) used has been found to be an efficient and green catalyst. The compounds reported
during this work were obtained in excellent yield, in a short duration of time and ease of work up. They were purified by
recrystalization from ethanol, and also the synthesized compounds were characterized by various spectroscopic techniques.

Conclusion:
The method offers several advantages such as safe, cost-effective and catalyst easily recovered and reused
for a minimum of five cycles, that confirms its good stability. Short reaction times, high yield and usage of eco-friendly
catalyst and solvent are the key features of this methodology.
Reformatie van de rentmeester. Een voorstel tot integratie van de zorg voor de schepping in gereformeerde theologie
Authors: Van Reenen M. 
Published: September 2020

Christians throughout the world feel the need to answer the questions arising from the climate debate. Orthodox-reformed theology in the Netherlands, however, pays these matters comparatively little attention. Three possible causes of this problem are: stewardship as discussed under the heading of creation; a certain slowness in consideration; and the suggestion that the Ten Commandments do not bear directly on this theme. This essay proposes a more integrated position. First, stewardship of the creation should be more closely linked to the image of God. Second, the Ten Commandments has the creation in view more often than assumed: ‘creation’ is also ‘your neighbour’. Third, in considering creation care as part of God’s ‘normal’ obligations towards us, the threefold function of the law must not be diminished.
Evaluation of prediction score of contrast-induced nephropathy in inpatients undergone to digital or CT angiography
Authors: Jesus-Silva Seleno Glauber de , Chaves Ana Elisa , Maciel Caio Augusto Alves , Scotini Edson Eziel Ferreira , Mesquita Pablo Girardelli Mendonça , De Moraes Silva Melissa Andreia , Cardoso Rodolfo Souza 
Published: September 2020

Objectives: To assess the incidence of contrast-induced nephropathy (CIN) and determine the Mehran Score's (MS) ability to predict CIN in patients undergoing digital angiography or computed tomography angiography. Methods: 252 medical records of inpatients who underwent DA or CTA over 28 months in a quaternary hospital were reviewed. CIN was defined as serum creatinine> 0.5 mg / dL or > 25% increase in baseline creatinine, 48 h after administration of iodinated contrast. The ROC curve and the area under the curve (AUC) were used as a score test. Results: The majority (159; 63.1%) were male, and the average age was 60.4 years. Anemia, diabetes mellitus, and age > 75 years were the most prevalent factors. The incidence of CIN was 17.8% (n = 45). There was a decrease in the mean values ​​of creatinine pre and post among patients who did not suffer CIN (1.38 ± 1.22 vs 1.19 ± 0.89; t = 3.433; p = 0.0007), while among patients who suffering CIN, the mean increase was 1.03 mg / dL (1.43 ± 1.48 vs 2.46 ± 2.35 mg / dL; t = 5.44; p = 0.117). The ROC curve analysis identified a low correlation between MS and the occurrence of CIN (AUC = 0.506). Conclusion: The incidence of CIN in hospitalized patients undergoing angiography or computed tomography angiography was high. The EM did not allow the prediction of NIC.
Artificial Intelligence and Its Effect on Dermatologists’ Accuracy in Dermoscopic Melanoma Image Classification: Web-Based Survey Study
Authors: Maron Roman C , Utikal Jochen S , Hekler Achim , Hauschild Axel , Sattler Elke , Sondermann Wiebke , Haferkamp Sebastian , Schilling Bastian , Heppt Markus V , Jansen Philipp , Reinholz Markus , Franklin Cindy , Schmitt Laurenz , Hartmann Daniela , Krieghoff-Henning Eva , Schmitt Max , Weichenthal Michael , von Kalle Christof , Fröhling Stefan , Brinker Titus J 
Published: September 2020

Background
Early detection of melanoma can be lifesaving but this remains a challenge. Recent diagnostic studies have revealed the superiority of artificial intelligence (AI) in classifying dermoscopic images of melanoma and nevi, concluding that these algorithms should assist a dermatologist’s diagnoses.

Objective
The aim of this study was to investigate whether AI support improves the accuracy and overall diagnostic performance of dermatologists in the dichotomous image–based discrimination between melanoma and nevus.

Methods
Twelve board-certified dermatologists were presented disjoint sets of 100 unique dermoscopic images of melanomas and nevi (total of 1200 unique images), and they had to classify the images based on personal experience alone (part I) and with the support of a trained convolutional neural network (CNN, part II). Additionally, dermatologists were asked to rate their confidence in their final decision for each image.

Results
While the mean specificity of the dermatologists based on personal experience alone remained almost unchanged (70.6% vs 72.4%; P=.54) with AI support, the mean sensitivity and mean accuracy increased significantly (59.4% vs 74.6%; P=.003 and 65.0% vs 73.6%; P=.002, respectively) with AI support. Out of the 10% (10/94; 95% CI 8.4%-11.8%) of cases where dermatologists were correct and AI was incorrect, dermatologists on average changed to the incorrect answer for 39% (4/10; 95% CI 23.2%-55.6%) of cases. When dermatologists were incorrect and AI was correct (25/94, 27%; 95% CI 24.0%-30.1%), dermatologists changed their answers to the correct answer for 46% (11/25; 95% CI 33.1%-58.4%) of cases. Additionally, the dermatologists’ average confidence in their decisions increased when the CNN confirmed their decision and decreased when the CNN disagreed, even when the dermatologists were correct. Reported values are based on the mean of all participants. Whenever absolute values are shown, the denominator and numerator are approximations as every dermatologist ended up rating a varying number of images due to a quality control step.

Conclusions
The findings of our study show that AI support can improve the overall accuracy of the dermatologists in the dichotomous image–based discrimination between melanoma and nevus. This supports the argument for AI-based tools to aid clinicians in skin lesion classification and provides a rationale for studies of such classifiers in real-life settings, wherein clinicians can integrate additional information such as patient age and medical history into their decisions.
Identification of Patient Perceptions That Can Affect the Uptake of Interventions Using Biometric Monitoring Devices: Systematic Review of Randomized Controlled Trials
Authors: Perlmutter Alexander , Benchoufi Mehdi , Ravaud Philippe , Tran Viet-Thi 
Published: September 2020

Background
Biometric monitoring devices (BMDs) are wearable or environmental trackers and devices with embedded sensors that
can remotely collect high-frequency objective data on patients’ physiological, biological, behavioral, and environmental
contexts (for example, fitness trackers with accelerometer). The real-world effectiveness of interventions using biometric monitoring devices depends on patients’ perceptions of these interventions.

Objective
We aimed to systematically review whether and how recent randomized controlled trials (RCTs) evaluating interventions using BMDs assessed patients’ perceptions toward the intervention.

Methods
We systematically searched PubMed (MEDLINE) from January 1, 2017, to December 31, 2018, for RCTs evaluating interventions using BMDs. Two independent investigators extracted the following information: (1) whether the RCT collected information on patient perceptions toward the intervention using BMDs and (2) if so, what precisely was collected, based on items from questionnaires used and/or themes and subthemes identified from qualitative assessments. The two investigators then synthesized their findings in a schema of patient perceptions of interventions using BMDs.

Results
A total of 58 RCTs including 10,071 participants were included in the review (the median number of randomized participants was 60, IQR 37-133). BMDs used in interventions were accelerometers/pedometers (n=35, 60%), electrochemical biosensors (eg, continuous glucose monitoring; n=18, 31%), or ecological momentary assessment devices (eg, carbon monoxide monitors for smoking cessation; n=5, 9%). Overall, 26 (45%) trials collected information on patient perceptions toward the intervention using BMDs and allowed the identification of 76 unique aspects of patient perceptions that could affect the uptake of these interventions (eg, relevance of the information provided, alarm burden, privacy and data handling, impact on health outcomes, independence, interference with daily life). Patient perceptions were unevenly collected in trials. For example, only 5% (n=3) of trials assessed how patients felt about privacy and data handling aspects of the intervention using BMDs.

Conclusions
Our review showed that less than half of RCTs evaluating interventions using BMDs assessed patients’ perceptions toward interventions using BMDs. Trials that did assess perceptions often only assessed a fraction of them. This limits the extrapolation of the results of these RCTs to the real world. We thus provide a comprehensive schema of aspects of patient perceptions that may affect the uptake of interventions using BMDs and which should be considered in future trials.

Trial Registration
PROSPERO CRD42018115522; https://tinyurl.com/y5h8fjgx
Penerapan Model Pembelajaran Kooperatif Tipe Roundtable Berbantuan Media Gambar Seri Dalam Meningkatkan Kemampuan Menulis Cerita Pendek Pada Siswa Sekolah Dasar
Authors: Agustina Hamelia 
Published: September 2020

Penelitian ini di laksanakan berdasarkan pada pelaksanaan proses pembelajaran yang dilakukan guru di sekolah. Permasalahan yang ditemui masih banyak siswa yang kesulitan dalam menulis, khususnya menulis suatu cerita pendek. Hal ini terbukti dari rendahnya perolehan nilai siswa dalam evaluasi menulis cerita pendek. Penelitian ini merupakan penilitian tindakan kelas ( PTK ) yang bertujuan untuk mengetahui penggunaan model pembelajaran kooperatif tipe roundtable berbantuan media gambar seri dalam meningkatkan kemampuan menulis cerita pendek pada siswa SD. Penelitian dilaksanakan dalam tiga siklus. Subjek penelitian adalah siswa kelas VI SDN No. 93/I Lopak Aur yang berjumlah 26 siswa, dimana data yang diambil yaitu berupa data observasi melalui lembar observasi kinerja guru dan aktivitas siswa yang dilakukan pada setiap proses pembelajaran Penilitian ini dilakukan 4 tahapan yaitu perencanaan, pelaksanaan,observasi dan refleksi.Hasil penelitian ini menunjukkan bahwa penggunaan model pembelajaran kooperatif tipe Roundtable berbantuan media gambar seri dapat meningkatkan kemampuan menulis cerita pendek siswa kelas VI di SD Negeri 93/I Lopak Aur.
Editors' Introduction to the Special Section on Cloud Computing and Accounting Information Systems (JISC 2018)
Authors: Schmidt Pamela J. , Gal Graham 
Published: September 2020

ABSTRACT
This introduction provides an overview to this special section and reports on the third Journal of Information Systems Conference (JISC 2018) held March 15 and 16, 2018 in Durham, NC. The conference was jointly sponsored by the AAA Accounting Information Systems (AIS) section and the Association of International Certified Professional Accountants (AICPA). This JIS research will help advance cloud computing research related to the domain of accounting information systems. The conference included seven research papers with related industry discussant feedback, three cloud industry keynote speakers, and three panels of practitioners and researchers to discuss the impact of the emergence and rapid maturing of cloud computing services. This editors' introduction outlines the major research paper topics represented in this special section, briefly introduces each paper, and highlights their main contributions. A comprehensive report on the full JISC 2018 conference is provided in the cloud commentary paper included in this special section.