bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture for amnestic mild cognitive impairment (aMCI): study protocol for a pilot multicenter, randomized, parallel controlled trial
Authors: Zhang Jiayu , Kuang Xu , Tang Chunzhi , Xu Nenggui , Xiao Songhua , Xiao Lingjun , Wang Shengwen , Lu Liming , Zhang Liang 
Published: January 2020

Abstract
Background: Patients with amnesic mild cognitive impairment (aMCI) are more likely to develop Alzheimer's disease (AD) than corresponding age normal population. Because AD is irreversible, early intervention for aMCI patients seems important and urgent. We have designed a pilot multicenter, randomized, parallel controlled trial to assess the efficacy and safety of acupuncture on aMCI, and explore the feasibility of acupuncture in the treatment of aMCI, so as to provide a reference for large-sample clinical trials in the next stage. Method: We designed a pilot multicenter, randomized, parallel controlled trial. This trial aims to test the feasibility of carrying out a large-sample clinical trial. In this trial, 50 eligible patients with aMCI will be included and allocated to acupuncture group (n = 25) or sham acupuncture group (n = 25) at random. Subjects will accept treatment 2 times a week for 12 weeks continuously, with a total of 24 treatment sessions. We will select six acupoints (GV20, GV14, bilateral BL18 , bilateral BL23). For the clinical outcomes, the primary outcome is Montreal cognitive assessment (MoCA), which will be assessed from baseline to the end of this trial. And the secondary outcomes are Mini-mental State Examination (MMSE), Delayed Story Recall (DSR), Clinical Dementia Rating scale (CDR), Global Deterioration Scale (GDS), Activity of Daily Life (ADL), Alzheimer's Disease Assessment Scale-Cognitive Section (ADAS-cog), brain Magnetic Resonance Imaging (MRI) , brain functional Magnetic Resonance Imaging (fMRI) and Event-related potential (ERP) P300, which will be assessed before and after treatment. In addition, we will asses the safety outcomes from baseline to the end of this trial and feasibility outcome after treatment. We will evaluate neuropsychological assessment scale (MoCA, MMSE, ADAS-cog) at 3 months and 6months after treatment. Discussion: This pilot trial aims to explore the feasibility of the trial, and verify essential information of its efficacy and safety. This pilot study will provide a preliminary basis for carrying out a larger clinical trial of acupuncture on aMCI in near future. Trial registration: Chinese Clinical Trial Registry , ChiCTR1900021557. Registered on 27 February 2019, http://www.chictr.org.cn/showproj.aspx?proj=35460. Keywords: amnestic Mild Cognitive Impairment , Acupuncture, Clinical trial
Preemptive Infiltration with Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE): A Study Protocol
Authors: Shrestha Niti , Wu Liang , Wang Xianodi , Jia Wenqing , Luo Fang 
Published: January 2020

Abstract
Background: Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these procedures, patients often experience severe postoperative pain at the surgical site. Intense immediate postoperative pain after many spinal procedures makes its control of utmost importance.Preemptive injection of local anesthetics can significantly reduce postoperative pain during rest and movement, however, the analgesic effect is maintained for a relatively short period of time. Whether betamethasone combined with local anesthetic for laminoplasty or laminectomyhas better short-term and long-term effects than the local anesthetic alone has not been reported yet. Method: The PRE-EASEtrial is a prospective, randomized, open-label, blinded endpoint, single-center clinical study including 116 participants scheduled for elective laminoplasty or laminectomy, with a 6 months’ follow-up process. Preemptive local infiltration with betamethasone and ropivacaine (treatment group) or ropivacaine alone (control group) throughout the entire thickness of the planned incision site will be performed by the surgeon, prior to making the incision. The primary outcome will be the cumulative butorphanol consumption within the first 48 hours’ postoperative period. Discussion: This study will add significant new knowledge to the effect and feasibility of preemptive local infiltration of betamethasone for postoperative pain management in laminoplasty and laminectomy.
Weight management barriers and facilitators after breast cancer in Australian women: a national survey
Authors: Ee Carolyn , Cave Adele Elizabeth , Naidoo Dhevaksha , Bilinski Kellie , Boyages John 
Published: January 2020

Abstract
Background Breast cancer is the most common cancer in women worldwide. Weight gain after breast cancer is associated with poorer health outcomes. The aim of this study was to describe how Australian breast cancer survivors are currently managing their weight.Methods Online cross-sectional survey open to any woman living in Australia who self-identified as having breast cancer, between November 2017 and January 2018.Results We received 309 responses. Most respondents described their diet as good/excellent and reported moderate-high levels of weight self-efficacy. Despite this, the proportion of overweight/obesity increased from 47% at time of diagnosis to 67% at time of survey. More than three quarters of respondents did not receive any advice on weight gain prevention at the time of diagnosis. 39% of women reported being less active after cancer diagnosis, and and few weight loss interventions were perceived to be effective. Facilitators were structured exercise programs, prescribed diets, and accountability to someone else, while commonly cited barriers were lack of motivation/willpower, fatigue, and difficulty maintaining weight. Women who cited fatigue as a barrier were almost twice as likely to be doing low levels of physical activity or no physical activity than women who did not cite fatigue as a barrier.Conclusions We report high levels of concern about weight gain after BC and significant gaps in service provision around weight gain prevention and weight management. Women with BC should be provided with support for weight gain prevention in the early survivorship phase, which should include structured physical activity and dietary changes in combination with behavioural change and social support. Weight gain prevention or weight loss programs should address barriers such as fatigue. More research is required on the effectiveness of diet and exercise interventions in BC survivors, particularly with regard to weight gain prevention.
Collective occurrence of rhabdomyolysis after high-intensity resistance training--- A prospective study
Authors: Tu Haitao , Cai Xiaoqing , Wang Liangliang , Wu Xingbo , Zhang Liangyou , Lu Huan , Wang Chao , Luo Yuanyuan , Yu Xuguang 
Published: January 2020

Abstract
Background: Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle components into systemic circulation. Common causes include high-intensity exercise, crush injury, high fever, drugs, and inflammation. Here, we have a prospective observational study of collective rhabdomyolysis caused by infrequent short-term high-intensity exercise. Methods: The patients were a group of adolescents, of which 35 developed severe muscle pain and dark-brown urine after military training and were hospitalized, while others developed mild symptoms and returned to school after relief of symptoms following outpatient treatment. We used SPSS 13.0 to calculate the sample mean and standard deviation of various laboratory indicators. Results: The average serum creatinine kinase was 33532.43±39982.95 U/L, and average serum lactate dehydrogenase was 1816.97±1413.59 U/L at the time of admission. When they were discharged, the above two indicators became 1902.2±1366.37 U/L and 210.31±61.27 U/L. Signs and symptoms improved in all patients after the intravenous injection of average 5000ml within 5.5 days of normal saline and balance solution and implementation of a bed rest regimen. No complications occurred (e.g., acute renal failure, disseminated intravascular coagulation, or electrolyte imbalance). All patients were relieved of symptoms and discharged after an average of 5.47 days of hospitalization. Of these, 20 patients were prescribed medical treatment and returned to the clinic within 1 month after discharge. Conclusions: Suddenly and dramatically increase the amount of exercises in a short period of time is easy to cause rhabdomyolysis. We hope that everyone can avoid similar situations.
Depression Does Not Predict Clinical Outcome of Chinese Peritoneal Dialysis Patients After Adjusting for the Degree of Frailty
Authors: CHAN Gordon Chun-Kau , NG Jack Kit-Chung , CHOW Kai-Ming , Kwan Bonnie CH , KWONG Vickie Wai-Ki , PANG Wing-Fai , CHENG Phyllis Mei-Shan , LAW Man-Ching , LEUNG Chi-Bon , LI Philip Kam-Tao , Szeto Cheuk Chun 
Published: January 2020

Abstract
Background Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal relationship between depression and frailty, and determined their relative contribution to the adverse clinical outcome in PD patients. Methods In a prospective observational study, we recruited 267 prevalent PD patients. Depression was identified by Patient Health Questionnaire (PHQ-9). Frailty was identified by a validated Frailty Score. All cases were followed for one year. Outcome measures included number and duration of hospitalization, peritonitis rate, and all-cause mortality. Results Of the 267 patients, 197 patients (73.8%) were depressed, and 157 (58.8%) were frail. There was a substantial overlap between depression and frailty. Although depression and frailty were associated the number and duration of hospitalization by univariate analysis, the association became insignificant after adjusting for confounding factors by multivariate analysis. Both depression and frailty were associated with one-year mortality by univariate analysis. One-year patient survival was 95.9%, 86.5%, 82.4% and 71.0% for patients with nil, mild, moderate and severe frailty, respectively (p = 0.001). Frailty was an independent predictor of patient survival by multivariate analysis (adjusted hazard ratio 1.424, 95% confidence interval 1.011-2.005. p = 0.043), while the prognostic effect of depression disappears after adjusting for frailty score. Conclusion Depression and frailty were common among Chinese PD patients. Frailty, but not depression, was an independent predictor of one-year mortality.
Screen time and eating during screen time: associations with dietary intake in children and adolescents
Authors: Jensen Melissa L , Carpentier Francesca Dillman , Corvalán Camila , Popkin Barry M. , Evenson Kelly , Adair Linda , Taillie Lindsey Smith 
Published: January 2020

Abstract
Background: Increased TV viewing is associated with overweight and obesity in children and adolescents. Excess weight gain might be a result of increased dietary intake during television viewing, eating foods that are highly advertised at other times, or lack of physical activity. The objectives of this cross-sectional study were (1) to determine the extent of screen time and eating during screen time, and the correlation between these two different exposures, (2) to compare food and nutrient consumption of on- versus off-screen eating occasions, and (3) to determine whether screen time and eating during screen time is associated with overall dietary intake.
Methods: Participants were part of the Food Environment Chilean Cohort (FEChiC, n=938, 4-6 y) and the Growth and Obesity Cohort Study (GOCS, n=752, 12-14 y), recruited in the southeast region of Santiago, Chile in 2016. Dietary data was collected via 24-h food recalls. For each eating occasion, participants or their primary caregiver reported activity performed during consumption. Analyses included Spearman correlations, multivariable linear regression models and logistic regression. For daily consumption analyses, post-hoc pairwise comparisons examined differences in our main outcomes by tertiles.
Results: In our sample, 87.5% reported consuming at least one meal or snack per day while on a screen. The median kilocalories contributed by eating during screen time was 387 kcal/d in children and 848 kcal/day in adolescents, which represents 34.7% and 42.3% of daily energy intake, respectively. There were no consistent differences in the nutrient profile or food groups consumed for either age group when comparing eating occasions consumed on-screen versus off-screen. Daily consumption analyses revealed that higher weekly hours of TV viewing was associated with elements of a less healthy diet including more sweets and desserts in children, and more sugar sweetened beverages in adolescents.
Conclusions: A large percentage of children and adolescents’ daily energy intake is consumed while watching television or on their phone. In depth, longitudinal work is needed to understand how screen time eating affects diet quality and nutritional status.
Efficacy of Different Recruitment Maneuvers for Improved Lung Inhomogeneity in a Pig Model of ARDS
Authors: Xia Feiping , Pan Chun , Wang Lihui , Liu Ling , Liu Songqiao , Guo Fengmei , Yang Yi , Huang Yingzi 
Published: January 2020

Abstract
Background: In acute respiratory distress syndrome (ARDS), lung recruitment maneuvers can recruit collapsed alveoli in gravity-dependent lung regions, improving the homogeneity of ventilation distribution. This study used electrical impedance tomography (EIT) to investigate the efficacy of different recruitment maneuvers for alveolar recruitment in a pig model of ARDS. Methods: ARDS was induced in ten healthy male pigs with repeated bronchoalveolar lavage until the arterial partial pressure of oxygen (PaO 2 )/fraction of inspired oxygen (FiO 2 ) (P/F ratio) was < 100 mmHg and remained stable for 30 minutes (TARDS). ARDS pigs underwent three sequential recruitment maneuvers, including sustained inflation (SI), increments of positive end-expiratory pressure (PEEP) (IP), and pressure-controlled ventilation (PCV) applied in random order, with 30 mins at a PEEP of 5 cmH 2 O between maneuvers. Respiratory mechanics, hemodynamics, arterial blood gas, and EIT were recorded at baseline, TARDS, and before and after each recruitment maneuver.Results: In all ten pigs, ARDS was successfully induced with a mean 2.8±1.03 (2800±1032.80ml) bronchoalveolar lavages. PaO 2 , SO 2 , P/F, and compliance were significantly improved after recruitment with SI, IP or PCV (all p<0.05), and there were no significant differences between maneuvers. Global inhomogeneity (GI) was significantly decreased after recruitment with SI, IP, or PCV. There were no significant differences in GI before or after recruitment with the different maneuvers. The decrease in GI (ΔGI) was significantly greater after recruitment with IP compared to SI (p=0.023), but there was no significant difference in ΔGI between IP and PCV. Conclusion: SI, IP, and PCV increased oxygenation, regional compliance and lung compliance, and decreased inhomogeneous gas distribution with no adverse effects on hemodynamics in ARDS pigs. IP significantly improved inhomogeneity of the lung compared to SI.
The efficacy and safety of intrathecal bupivacaine alone versus bupivacaine combined with magnesium sulfate in adults using spinal anesthesia: a meta-analysis of randomized controlled trials
Authors: Wang Mi-Zhou , Dong Rui , Jia Li-Na , Ai Deng-Bin , Zhang Jian-Hua 
Published: January 2020

Abstract
Background: Several studies have investigated the effects of intrathecal magnesium sulfate as an adjuvant for bupivacaine; however, their conclusions are inconsistent. Therefore, it is necessary to conduct a meta-analysis on this topic.Methods We searched Pubmed, EMBASE (OvidSP) and Cochrane Central Register of Controlled Trials (CENTRAL) for randomized controlled trials (RCTs) comparing the effect of intrathecal bupivacaine combined with magnesium sulfate versus bupivacaine alone in adults using spinal anesthesia.Results Eighteen studies that met our inclusion criteria were included in our analysis. We found that the addition of intrathecal magnesium sulfate to bupivacaine provided a longer duration of analgesia (SMD 0.99; 95% CI [0.45, 1.52], P = 0.0003, I2 = 93%), prolonged the duration of sensory block (MD=106.69; 95% CI, 60.93-152.45; P<0.00001), delayed the onset of sensory block (SMD 1.20; 95% CI [0.65, 1.75], P =<0.0001, I2 = 91%) and motor block (SMD 1.46; 95% CI [0.23, 2.69], P =0.02, I2 = 96%), decreased the requirement for rescue analgesia (SMD -0.81; 95% CI [-1.06, -0.56], P < 0.00001, I2 = 11%). For duration of motor block, and incidence of postoperative adverse events (such as nausea and vomiting, hypotension, bradycardia, pruritus, shivering and neurological deficit), no statistically differences were observed between the 2 groups.Conclusions Our meta-analysis demonstrated that intrathecal magnesium sulfate combined with bupivacaine prolongs the dusration of analgesia, without an impact on the adverse events. However, the quality of evidence was very low when using GRADE to assess it. Given adverse effects before use, more high-quality trials with large samples are required before magnesium sulfate is routinely used as a intrathecal adjunct.
Troponin I as a mortality marker after lung resection surgery – a prospective cohort study.
Authors: Uchoa Ricardo , Caramelli Bruno 
Published: January 2020

Abstract
Background: Cardiovascular complications associated with thoracic surgery increase morbidity, mortality, and treatment costs. Elevated cardiac troponin level represents a predictor of complications after non-cardiac surgeries, but its role after thoracic surgeries remains undetermined. The objective of this study was to analyze the relationship between troponin I elevation and morbidity and mortality after one year in patients undergoing lung resection surgery. Methods : This prospective cohort study evaluated 151 consecutive patients subjected to elective lung resection procedures using conventional and video-assisted thoracoscopic techniques at a University Hospital in Brazil, from July 2012 to November 2015. Preoperative risk stratification was performed using the scores obtained by the American College of Physicians (ACP) and the Society of Cardiology of the state of São Paulo (EMAPO) scoring systems. Troponin I levels were measured in the immediate postoperative period (POi) and on the first and second postoperative days. Results : Most patients had a low risk for complications according to the ACP (96.7%) and EMAPO (82.8%) scores. Approximately 49% of the patients exhibited increased troponin I (≥0.16 ng/ml), at least once. Multivariate analysis showed that the elevation of troponin I, on the first postoperative day, correlated with a 12-fold increase in mortality risk within one year (HR 12.02, 95% CI: 1.82-79.5; p=0.01). Conclusions : In patients undergoing lung resection surgery, with a low risk of complications according to the preoperative evaluation scores, an increase in troponin I levels above 0.16 ng/ml in the first postoperative period correlated with an increase in mortality within one year. Keywords: Troponin, non-cardiac surgery, thoracic surgery, cardiovascular complications, cardiovascular risk, perioperative care.
Long-term, in toto live imaging of the developing mouse heart
Authors: Yue Yanzhu , Li Xin , Zhang Youdong , He Aibin 
Published: January 2020

Abstract
Mapping holistic cell behaviors sculpting mammalian heart has been a goal, but so far only successes in transparent invertebrates and lower vertebrates. Using a live-imaging system comprising a customized vertical light-sheet microscope equipped with a culture module, a heartbeat-gated imaging strategy, and a digital image processing framework, we realized imaging of developing mouse hearts with uninterrupted cell lineages for up to 1.5 days. Four-dimensional landscapes of cell behaviors revealed a blueprint for ventricle chamber formation in which biased outward migration of outermost cardiomyocytes coupled with cell intercalation and horizontal division. The trabeculae, an inner muscle architecture, was developed through early fate segregation and transmural cell arrangement involving both oriented cell division and directional migration. Thus, live-imaging reconstruction affords a transformative means for deciphering mammalian organogenesis.
Developing smart Tele-ECG system for early detection and monitoring heart diseases based on ECG signal: progress and challenges
Authors: Jatmiko Wisnu , Ma’sum M. Anwar , Wisesa Hanif Arief , Sanabila Hadaiq Rolis 
Published: January 2020

Abstract
Technology is developed to benefit society. One of the applications of technology in the healthcare sector is telehealth monitoring system. The system proposes a new way of communication between the doctor and the patient, even in a very remote location. In this paper, we elaborate the progress and challenges regarding the development of Tele-ECG in Indonesia, which includes data acquisition, feature extraction, data compression, classification algorithm, mobile and web development system and small device implementation on an FPGA board. The classification is conducted by using LVQ, GLVQ, FNLVQ, FNLVQ-PSO, FNGLVQ, and AM-GLVQ. The compression is conducted by using SPIHT algorithm. Tele-ECG can assist in monitoring heartbeat anomalies and reduce the risk of heart attack. It could also be a solution for infrastructure discrepancy in healthcare.
Optimization of the sorption of selected polycyclic aromatic hydrocarbons by regenerable graphene wool
Authors: Adeola Adedapo O. , Forbes Patricia B. C. 
Published: January 2020

Abstract
A novel graphene wool (GW) material was used as adsorbent for the removal of phenanthrene (PHEN) and pyrene (PYR) from aqueous solution. Adsorption kinetics, adsorption isotherms, thermodynamics of adsorption and effect of pH, ionic strength, and temperature on the adsorption of PHEN and PYR onto GW were comprehensively investigated. Isothermal and kinetic experimental data were fitted to Langmuir, Freundlich, Temkin, Sips and Dubinin–Radushkevich models, as well as pseudo-first-order and pseudo-second-order kinetic models. The adsorption kinetic data best fit the pseudo-second-order kinetic model for PHEN and PYR sorption with R2 value &gt;0.999, whilst the Sips model best fit isotherm data. Kinetic data revealed that 24 hr of contact between adsorbent and polycyclic aromatic hydrocarbons (PAHs) was sufficient for maximum adsorption, where the Langmuir maximum adsorption capacity of GW for PHEN and PYR was 5 and 20 mg g−1 and the optimum removal efficiency was 99.9% and 99.1%, respectively. Thermodynamic experiments revealed that adsorption processes were endothermic and spontaneous. Desorption experiments indicated that irreversible sorption occurred with a hysteresis index greater that zero for both PAHs. The high adsorption capacity and potential reusability of GW makes it a very attractive material for removal of hydrophobic organic micro-pollutants from water.