bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the asymmetric response of the exchange rate to shocks in the crude oil market
Authors: Alqaralleh Huthaifa 
Published: March 2020

Purpose
This paper aims to investigate the nonlinear dynamics in the effects of oil price shocks on the exchange rate for a sample from the Group of Twenty (G20) over the period 1994:1-2019:1.

Design/methodology/approach
Using monthly time series data covering the period1994:1-2019:1, the author first use the non-parametric triples test of Randles et al. (1980) to ascertain the existence of asymmetric properties in the sample of exchange rates. Then the author used the nonlinear ARDL cointegration approach developed by Shin et al. (2014) to examine the reaction of these exchange rates to the oil price shocks.

Findings
This study has identified significant evidence that the exchange rate is asymmetrically distributed, with the effect that high appreciation of the exchange rate is followed by slower depreciation. The NARDL results support such asymmetry even more strongly because in the test the exchange rate is shown to react differently in the long term to positive and negative shocks in oil prices. Another major finding was that the speed of adjustment differed over the sample, as the cumulative dynamic multipliers effect highlighted.

Research limitations/implications
This change in direction and the employment of non-linear technique can be to obtain better insight into the model specification, which the author believes, will not only enhance the findings in the literature but also enhance forecasting and decision-making.

Practical implications
A practical implication of this change is the possibility that policymakers and participants concerned with exchange rate stability should intervene in the market to alleviate the unfavourable impact of oil price shocks on the exchange rate.

Originality/value
Addressing this nonlinear dynamic in the effects of oil price shocks on the exchange rate have at least the following two important reasons: asymmetry and regime change are types of nonlinearities that affect the market dynamics, especially, over marked sample period with such financial crises as the global financial crises of 2007, thereby violating the linear models. Adopting an asymmetric cointegration technique permits to incorporate cointegrated positive and negative components of the considered series.
Study on seismic behavior reduction of typical joints for monolithic precast concrete frame structures with ages
Authors: Zhong Qidi , Ding Jianguo , Zhang Xiangxiang , Zhang Yin 
Published: March 2020

PurposeMonolithic precast concrete frame structures have been promoted and developed in recent years. Owing to material deterioration and a weaker structural integrity, monolithic precast concrete frame structures may suffer from insufficient seismic capacity as service time increases. A typical joint of monolithic precast concrete frame structure is studied in this paper. The purpose of this paper is to perform numerical modeling of the typical joint subjected to low cyclic load at different ages and analyze the hysteretic behavior reduction with ages under common atmosphere environment.Design/methodology/approachExisting un-carbonated concrete, carbonated concrete and corroded rebar are all considered as deterioration factors for the typical joint, whose constitutive models are introduced into the finite element model to study. Moreover, time-dependent constitutive model of existing un-carbonated concrete and mechanical model of bond between precast and cast-in-place concrete are established on the basis of existing experimental data. Then, finite element method is used to investigate the seismic property reduction of the typical joint, where nonlinear springs are set to simulate bonding between precast and cast-in-place concrete.FindingsAnalyzing the results, the reduction of reaction force from skeleton curves of the joint is significant in the first 30 years of service time, and slows down after 30 years. Besides, the ductility, secant stiffness and equivalent viscous damping coefficient of the typical joint remain almost unchanged in the first decade, but decrease obviously after 10 years.Originality/valueThe originality of the paper consists in the following. The time-dependent constitutive model of existing un-carbonated concrete is established and used in finite element method. Besides, bonding between precast and cast-in-place concrete is considered using nonlinear springs. There is a reference value for the seismic performance assessment of existing monolithic precast concrete frame structures.
Intravenous ferric carboxymaltose for iron deficiency anemia in dialysis patients: Effect of a new protocol adopted for a hemodialysis limited assistance center
Authors: Gobbi Laura , Scaparrotta Giuseppe , Rigato Matteo , Cattarin Leda , Qassim Laila , Carraro Gianni , Rossi Barbara , Calò Lorenzo A. 
Published: March 2020

AbstractIron and erythropoietin deficiencies are determinants of anemia in chronic kidney disease. In hemodialysis (HD) patients, intravenous (IV) iron is associated with a greater hemoglobin (Hb) production and better erythropoietin response but may be associated to hypersensitivity reaction. After the 2013 European Medicines Agency report regarding early detection/management of iron allergic reactions, IV iron administration dramatically reduced in Italian Hemodialysis‐Limited‐Assistance‐Centre (HD‐CAL) where a physician is present only once a week. Objective of the study was providing an effective and secure IV iron administration protocol for HD‐CAL patients. IV ferric carboxymaltose (FCM) administration was more effective and better tolerated than sodium ferric gluconate for iron deficiency correction and resolution of anemia in 24 patients undergoing HD in our HD‐CAL. Six months of FCM IV treatment once a week increased ferritin and Hb compared to sodium ferric gluconate once a week leading to decreased erythropoietin consumption from 24 000 to 15 000 U/patient/week with an erythropoietin annual expense reduction. No blood transfusions, gastrointestinal intolerance or other adverse effects were reported. The FCM IV administration protocol for our HD‐CAL patients was safe and no adverse events were reported, resulting in significantly increased ferritin, transferrin saturation, and Hb levels, reduction of erythropoietin requirements, and consequently reduction of erythropoietin expenses.
Zinc, an unexpected integrator of metabolism?
Authors: Danchin Antoine 
Published: March 2020

SummaryEven when they no longer require the presence of iron, cells use zinc as a divalent cation, involved in a large variety of catalytic and regulatory functions. This metal is so important that it appears that ribosomes are instrumental in its ultimate storage. Here, we summarize a detailed analysis which investigates the way the global cell metabolism is integrated by zinc. This integration results from the zinc‐dependent way in which the one‐carbon metabolism is always coupled to the translation process, not only via methionine and S‐adenosylmethionine, but via the complex set‐up of the modification of the position 34 of the anticodon of tRNAs.
LncRNA SNHG14 contributes to the progression of NSCLC through miR‐206/G6PD pathway
Authors: Zhao Lin , Zhang Xiaodong , Shi Yantong , Teng Tianlu 
Published: March 2020

BackgroundPrevious studies have shown that the dysregulation of lncRNAs participates in non‐small cell lung cancer (NSCLC) development. The purpose of this study was to research the biological function of lncRNA SNHG14 and its molecular mechanism in NSCLC progression.MethodsRT‐PCR was applied for investigating the expression of SNHG14, miR‐206 and G6PD. The progression of NSCLC was detected by CCK‐8, Transwell and western blot assays. The targets of SNHG14 and miR‐206 were measured by dual‐luciferase reporter assay.ResultsWe found a higher expression of SNHG14 in NSCLC and upregulation of SNHG14 contributed to NSCLC cell proliferation, invasion and migration. However, knockdown of SNHG14 showed the opposite effect on the progression of NSCLC. Specifically, SNHG14 negatively regulated miR‐206 expression by binding with it directly. Furthermore, G6PD served as the target of miR‐206. Rescue experiments showed that SNHG14 promoted G6PD expression by inhibiting miR‐206.ConclusionsLncRNA SNHG14 contributed to NSCLC progression through miR‐206/G6PD axis, providing novel clues for understanding the mechanism of NSCLC.
Efficacy and safety of treatment with dupilumab for severe asthma: A systematic review of the EAACI guidelines—Recommendations on the use of biologicals in severe asthma
Authors: Agache Ioana , Song Yang , Rocha Claudio , Beltran Jessica , Posso Margarita , Steiner Corinna , Alonso‐Coello Pablo , Akdis Cezmi , Akdis Mubeccel , Canonica Giorgio Walter , Casale Thomas , Chivato Tomas , Corren Jonathan , del Giacco Stefano , Eiwegger Thomas , Firinu Davide , Gern James E. , Hamelmann Eckard , Hanania Nicola , Mäkelä Mika , Martín Irene Hernández , Nair Parameswaran , O'Mahony Liam , Papadopoulos Nikolaos G. , Papi Alberto , Park Hae‐Sim , Pérez de Llano Luis , Quirce Santiago , Sastre Joaquin , Shamji Mohamed , Schwarze Jurgen , Canelo‐Aybar Carlos , Palomares Oscar , Jutel Marek 
Published: March 2020

AbstractDupilumab, a fully human monoclonal antibody against interleukin‐4 receptor α, is approved as add‐on maintenance treatment for inadequately controlled type 2 severe asthma. This systematic review evaluated the efficacy, safety and economic impact of dupilumab compared to standard of care for uncontrolled severe asthma. PubMed, EMBASE and Cochrane Library were searched for RCTs and health economic evaluations. Critical and important asthma‐related outcomes were evaluated. The risk of bias and the certainty of the evidence were assessed using GRADE. Three RCTs including 2735 subjects >12 years old and 24‐52 weeks of follow‐up were included. Dupilumab reduced with high certainty severe asthma exacerbations (Incidence rate ratio 0.51; 95% CI 0.45‐0.59) and the percentage use of oral corticosteroid use (mean difference (MD) −28.2 mg/d; 95% CI −40.7 to −15.7). Asthma control (ACQ‐5), quality of life (AQLQ) and rescue medication use [puffs/d] improved, without reaching the minimal important clinical difference: ACQ‐5 MD −0.28 (95% CI −0.39 to −0.17); AQLQ MD +0.28 (95% CI 0.20‐0.37); and rescue medication MD −0.35 (95% CI −0.73 to +0.02). FEV1 increased (MD +0.15; 95% CI +0.11 to +0.18) (moderate certainty). There was an increased rate of dupilumab‐related adverse events (AEs) (moderate certainty) and of drug‐related serious AEs (low certainty). The incremental cost‐effectiveness ratio of dupilumab versus standard therapy was 464 000$/QALY (moderate certainty). More data on long‐term safety are needed both for children and for adults, together with more efficacy data in the paediatric population.
The 60‐kDa heat shock protein regulates energy rearrangement and protein synthesis to promote proliferation of multiple myeloma cells
Authors: Wu Xiaoxiao , Guo Jianying , Chen Yuling , Liu Xiaohui , Yang Guangzhong , Wu Yin , Tian Ying , Liu Nian , Yang Lin , Wei Songren , Deng Haiteng , Chen Wenming 
Published: March 2020

SummaryTo investigate the cellular mechanisms of multiple myeloma (MM), we used liquid chromatography‐tandem mass spectrometry for proteomics analysis of CD138+ plasma cells from patients with MM and healthy controls. We found that the 60‐kDa heat shock protein (HSP60, also known as HSPD1) was significantly upregulated in myeloma cells. HSP60 is an important chaperone protein that regulates the homeostasis of mitochondrial proteins and maintains mitochondrial function. Knockdown (KD) of HSP60 in myeloma cells resulted in inhibition of proliferation and reduced the quality of the mitochondria. Mitochondrial stress tests showed that HSP60 KD inhibited glycolysis and mitochondrial activity. Metabolomics showed a decrease in glycolysis and tricarboxylic acid cycle metabolites, and inhibited the formation of creatine and phosphocreatine by the reaction of S‐adenosylmethionine (SAM) with amino acids mediated by demethyladenosine transferase 1, mitochondrial (TFB1M) and reduced energy storage substances. Moreover, HSP60 silencing influenced the synthesis of ribonucleotides and nicotinamide adenine dinucleotide phosphate (NADPH) by the pentose phosphate pathway to inhibit cell proliferation. HSP60 KD inhibited 5' adenosine monophosphate‐activated protein kinase (AMPK), which inhibited the key enzyme 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3), effecting the metabolism of fatty acids by inhibiting malonyl‐coenzyme A. Our data suggest that reduced HSP60 expression alters metabolic reprogramming in MM, inhibits tumour progression and reduces mitochondrial‐dependent biosynthesis, suggesting that HSP60 is a potential therapeutic target for MM treatment.
Single cell imaging with near‐field terahertz scanning microscopy
Authors: Li Zaoxia , Yan Shihan , Zang Ziyi , Geng Guoshuai , Yang Zhongbo , Li Jiang , Wang Lihua , Yao Chunyan , Cui Hong‐Liang , Chang Chao , Wang Huabin 
Published: March 2020

AbstractObjectivesTerahertz (THz)‐based imaging techniques hold great potential for biological and biomedical applications, which nevertheless are hampered by the low spatial resolution of conventional THz imaging systems. In this work, we report a high‐performance photoconductive antenna microprobe‐based near‐field THz time‐domain spectroscopy scanning microscope.Materials and methodsA single watermelon pulp cell was prepared on a clean quartz slide and covered by a thin polyethylene film. The high performance near‐field THz microscope was developed based on a coherent THz time‐domain spectroscopy system coupled with a photoconductive antenna microprobe. The sample was imaged in transmission mode.ResultsWe demonstrate the direct imaging of the morphology of single watermelon pulp cells in the natural dehydration process with our near‐field THz microscope.ConclusionsGiven the label‐free and non‐destructive nature of THz detection techniques, our near‐field microscopy‐based single‐cell imaging approach sheds new light on studying biological samples with THz.
Full‐genome analysis of hepatitis C virus in HIV‐coinfected hemophiliac Japanese patients
Authors: Ishida Yuki , Hayashida Tsunefusa , Sugiyama Masaya , Uemura Haruka , Tsuchiya Kiyoto , Kikuchi Yoshimi , Mizokami Masashi , Oka Shinichi , Gatanaga Hiroyuki 
Published: March 2020

AimMore than 1400 Japanese hemophiliacs acquired HIV infection around 1983 through contaminated blood products imported from the USA, most of whom also acquired hepatitis C virus (HCV) infection. To delineate the HCV genetic relations in HIV‐coinfected hemophiliacs, we analyzed stocked plasma samples of the patients seen at the largest referral center for HIV care in Japan.MethodsHepatitis C virus full‐genome sequences were amplified and determined using next‐generation sequencing, and genotyping and phylogenetic analyses of these sequences were carried out. The results of these hemophiliacs were compared with those of previously studied HIV‐coinfected Japanese non‐hemophiliacs who had undergone similar analysis of HCV full‐genome sequences.ResultsFrom 1997 to the end of 2017, 72 HIV‐infected Japanese hemophiliacs regularly visited our outpatient clinic. Of these, 51 patients had detectable plasma HCV‐RNA. The HCV full genome was successfully amplified and sequenced in 50 patients. Not only HCV genotypes 1b (28%) and 2a (6%), which are common in Japan, but also HCV genotypes 1a (32%) and 3a (22%) were identified at high frequency. A single case of intergenotypic recombinant form (2b/1a) and a single case of mixed infection (1a and 3a) were also identified. Each sequence derived from hemophiliacs was more than 0.05 genetic distance away from the other sequences in phylogenetic analysis.ConclusionsVarious HCV genotypes were identified in Japanese hemophiliacs, a finding that reflects the HCV genotypic distribution in the USA. The genetic distance among them are the results of viral evolution in each patient plus HCV genetic diversity in the USA.
Development and psychometric properties of the public attitude towards vaccination scale – Health belief model
Authors: Kocoglu‐Tanyer Deniz , Dengiz Kubra Sultan , Sacikara Zeynep 
Published: March 2020

AbstractAimThe aim of this study was to develop and psychometrically evaluate the Public Attitude Towards Vaccination Scale – Health Belief Model.DesignA methodological and prospective psychometric study.MethodA three‐phase construct was used to develop the Public Attitude Towards Vaccination Scale – Health Belief Model and to determine its psychometric properties: (1) creation of the item pool/conceptualization; (2) evaluation of the items; and (3) psychometric evaluation. This scale was tested using the construct validity (exploratory and confirmatory factor analyses) and the reliability analysis. A psychometric assessment of the scale was conducted with 586 individuals. Data were collected between January ‐ April 2018.ResultsItems of the scale were obtained by appraising the literature concerning vaccination and the other Health Belief Model scale and conducting interviews with mothers. The content validity ratio of this scale calculated according to experts’ opinions ranged between 0.769 and 1.00. According to the exploratory factor analysis, there were five factors with an eigenvalue higher than 1 in the scale. These five factors accounted for 68.9% of the total variance. In confirmatory factor analysis, values of fit indices were excellent or acceptable. This scale had high internal consistency and test–retest reliability.ConclusionThis study successfully developed the Public Attitude Towards Vaccination Scale – Health Belief Model. In addition to researchers, this scale can be used by nurses while providing counselling for people with vaccine hesitancy/refusal.ImpactThis measurement tool can be used to understand and address ‘vaccine hesitancy’ by researchers. The results of the research using this measurement tool will provide valuable information to policymakers for preventing vaccine hesitancy. The validity and reliability of this scale can easily be conducted in different languages.
ZebrafishDanio rerioshows behavioural cross‐context consistency at larval and juvenile stages but no consistency between stages
Authors: Alfonso Sébastien , Peyrafort Manon , Cousin Xavier , Bégout Marie‐Laure 
Published: March 2020

AbstractCoping style is defined as a set of individual physiological and behavioural characteristics that are consistent across time and context. In the zebrafishDanio rerio, as well as in many other animals, several covariations have been established among behavioural, physiological and molecular responses. Nonetheless, not many studies have addressed the consistency in behavioural responses over time starting at the larval stage. Therefore, this study aimed to improve the understanding of behavioural consistency across contexts and over time in zebrafish from the larval to juvenile stages. Two distinct experiments were conducted: a larval stage experiment (from 8 to 21 days post fertilization, dpf) and a juvenile stage experiment (from 21 to 60 dpf). On one hand, the larval experiment allows to focus on the transition between 8 and 21 dpf, marked by significant morphological changes related to the end of larval stage and initiation of metamorphosis. On the other hand, the juvenile experiment allows to properly cover the period extending from the end of larval stage to the juvenile stage (60 dpf), including metamorphosis which is itself completed around 45 dpf. Within each experiment, boldness was determined using a group risk‐taking test to identify bold and shy individuals. A novel environment test was then performed at the same age to evaluate consistency across contexts. Groups of fish (either bold or shy) were bathed in an alizarin red S solution for later identification of their initially determined coping style to evaluate behavioural consistency over time. Fish were then reared under common garden conditions and challenged again with the same behavioural tests at a later age (21 and 60 dpf in the larval and juvenile experiments, respectively). Behavioural consistency was observed across contexts, with bold fish being more active and expressing higher thigmotaxis regardless of age. There was, however, little behavioural consistency over age, suggesting behavioural plasticity during development. Moreover, the use of alizarin red S to conduct this experiment provides new perspectives for the further study of the longitudinal evolution of various traits, including behaviour, over life stages in fish.
Upper gastrointestinal mucosal injury associated with ticagrelor plus aspirin, ticagrelor alone, or aspirin alone at 1‐year after coronary artery bypass grafting
Authors: Tang Chenyue , Zhu Yunpeng , Yang Xiaobo , Xu Bin , Ye Cong , Yang Yi , Zhong Jie , Zhao Qiang , Yu Lifen 
Published: March 2020

AbstractBackground and AimThe presence and severity of upper gastrointestinal mucosal lesions have not been evaluated using esophagogastroduodenoscopy (EGD) in patients receiving ticagrelor plus aspirin or alone after myocardial revascularization. We assessed upper gastrointestinal mucosal injury and the use of proton pump inhibitors (PPIs) in patients receiving 1 year of antiplatelet therapy after coronary artery bypass grafting (CABG).MethodsIn this single‐center prospective substudy of a randomized trial, 231 patients completing 1‐year antiplatelet therapy (ticagrelor 90 mg twice daily plus aspirin 100 mg once daily, ticagrelor 90 mg twice daily, or aspirin 100 mg once daily, in 81, 80, and 70 patients, respectively) after CABG underwent 13C urea breath testing and EGD. Gastroduodenal lesions were assessed by modified Lanza score, and reflux esophagitis was evaluated according to Los Angeles classification. Additionally, at least one ulcer ≥ 5 mm was separately analyzed.ResultsAmong 231 patients, EGD showed 28 (12.1%) with ulcers ≥ 5 mm, which were detected in 13.6% (11/81) of ticagrelor plus aspirin recipients, 8.8% (7/80) of ticagrelor recipients, and 14.3% (10/70) of aspirin recipients, and 24 (10.4%) had reflux esophagitis. Eighty‐eight (38.1%) patients had a positive 13C urea breath testing after 1 year of treatment, and one patient received eradication therapy during follow up. Nineteen (8.2%) patients received a PPI for ≥ 6 months.ConclusionsSevere upper gastrointestinal mucosal lesions were more frequently observed in patients treated with ticagrelor plus aspirin and aspirin monotherapy than in patients treated with ticagrelor monotherapy for 1 year post‐CABG. Prophylactic use of PPIs might be inadequate.