bluuebunny/crossref_metadata_2025_split huggingface dataset:
LEACH-MTC: A Network Energy Optimization Algorithm Constraint as Moving Target Prediction
Authors: HU Zhen-tao , JIN Yong , Zhou Lin , WANG Chen , LI Ji-fang 
Published: July 2020

Abstract
When some nodes cooperatively track moving targets in wireless sensor network, some things including network working node selection and network energy consumption are influenced. Thus, this paper proposes an improved algorithm LEACH-MTC (LEACH with Moving Target Constraint) based on low energy adaptive clustering hierarchy protocol (LEACH). Firstly, based on the two-step linearization of the nonlinear dynamic model, the state of nonlinear moving target is predicted by the extended Kalman filter (EKF). Secondly, combining the state prediction of moving target and the performance of collaborative monitoring, this paper constructs an ellipse monitoring area of some working nodes to consist with the direction of the target movement. Subsequently, the node sleep strategy corresponding to the state prediction of moving target is designed. Finally, the cluster head selection strategy is proposed based on energy balance utilizing the state prediction of the moving target. Simulation results show that the proposed LEACH-MTC algorithm can not only ensure the real time consistency between the changing direction of area and the direction of target movement, but also increase the number of working nodes’ survival and reduce the network energy consumption.
Building Supramolecular Chirality in Organic Solar Cells Enables High-Performing Circularly Polarized Light Detection
Authors: Liu Lixuan , Yang Yang , Zhang Jianqi , Memon Waqar , Zhang Yajie , Wei Zhixiang 
Published: July 2020

Abstract
High-performing direct circularly polarized light (CPL) detectors are urgently needed for the development of chiral optoelectronics. We herein report the direct CPL detectors based on chiral organic small-molecule donor–fullerene acceptor bulk heterojunction organic solar cells (OSCs). By building supramolecular chirality in active layer of OSCs, the chiral OSC demonstrates its highest short-circuit current dissymmetry factor of 0.17 among state-of-the-art direct CPL detectors possessing intrinsic chirality. It demonstrates a significant difference in responsivity of 40 mA W− 1 upon opposite CPL illumination, four times higher than that of the best reported chiral perovskite CPL detectors to date. The association between the device metrics crucially relating to CPL detection and the anisotropic factor (g-factor) of the active layers revealed that supramolecular chirality is vital to the CPL detectability of OSCs. Given unique but ubiquitous observed supramolecular chirality induction and transfer in organic conjugated systems, highly sensitive CPL detectors based on chiral OSCs show great potential for promoting the development of practical direct CPL detection.
Target SARS-CoV-2: Computation of Binding energies with drugs of Dexamethasone/Umifenovir by Molecular Dynamics using OPLS-AA force field
Authors: Na Sk. Md , R M. Srinivasa 
Published: July 2020

Abstract
Molecular Dynamics simulation using Gromacs with OPLS-AA force field is performed for 100ns between SARS-CoV-2 main protease and Dexamethasone / Umifenovir drugs at 300 K/1 atm pressure. The trajectory of Root Mean Square Deviation (RMSD) and Radius of Gyration(Rg) emphasized the achievement of equilibrium and compactness. The drug-binding affinities on SARS-CoV-2 main protease are estimated via MM/PBSA method. The sign with magnitude of computed Gibbs free energy indicated the presence of strong interactions between SARS-CoV-2 and drugs of Dexamethasone / Umifenovir. The study revealed that the drug Dexamethasone is more effective over Umifenovir in binding SARS-CoV-2 main protease.
Identification of Key Genes and Evaluation of Their Prognosis Potential in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis
Authors: Liu Jankun , liu zy , Li Wei , Pan Xinghua , Fan Zongjiang , Zhang Shurong 
Published: July 2020

Abstract
Background

Hepatocellular carcinoma (HCC) is a malignancy causing highly death rate in the world. Despite the development of treatment strategies for HCC, prognosis of this malignancy remains unsatisfactory. In this study, we aimed to identify the target genes associated with the prognosis of HCC patients.
Methods

Three expression profiles of HCC tissues were extracted from the Gene Expression Omnibus database to explore the differentially expressed genes (DEGs) using GEO2R method. Functional enrichment analysis was performed to reveal the biological characteristics of DEGs. Protein-protein interaction (PPI) network was constructed using Cytoscape software. The survival curve of identified DEGs were tested by Kaplan-Meier analysis.
Results

We identified 15 DEGs (CYP39A1, CYR61, FOS, FOXO1, GADD45B, ID1, IL1RAP, MT1M, PHLDA1, RND3, SDS, SOCS2, TAT, S100P, and SPINK1) in HCC tissues. Prognosis analysis showed that 4 DEGs (FOXO1,SPINK1༌SOCS2, and TAT) correlated with overall survival time of HCC patients, which might serve as therapeutic targets for HCC patients.
Conclusions

By integrated bioinformatics analysis, we proposed a novel way to reveal key genes that closely relate to HCC development.
Correlation Analysis Between Hematological Toxicity and Body Composition in Patients With Diffuse Large B Cell Lymphoma Treated With CHOP±R Regimen
Authors: Zhao Wenhao , Liu Xuelian , Liu Xiangliang , Yang Haimei , Ji Wei , Li Wei 
Published: July 2020

Abstract
Purpose: The tolerance of patients withdiffuse large B cell lymphoma（DLBCL） receiving CHOP±R regimen was significantly different, and grade 3~4 hematologic toxicity after chemotherapy in some patients resulted in prolonged hospital stay, increased risk of infection, delayed treatment, and directly or indirectly affected short-term efficacy and long-term prognosis. Lean body mass（LBM）and L3 skeletal muscle index （L3SMI）obtained from abdominal CT of DLBCL patients were analyzed to determine whether they could be used as independent predictors of hematological toxicity of CHOP± R regimen in DLBCL patients.Methods: The patients with DLBCL who underwent CHOP±R regimen at the Cancer Center of the First Hospital of Jilin University from January 2015 to November 2018 were retrospectively analyzed. The abdominal CT of the patient was analyzed by sliceOmatic5.0 software. The third lumbar disc planar imaging was selected, and two consecutive images were taken to calculate LBM and L3SMI. Single factor and multivariate analysis were performed on the correlation of LBM, L3SMIand chemotherapy-related grade 3~4 hematologic toxicity. The ROC curve was drawn to investigate the predictive value of various human indicators on the hematologic toxicity of grade 3~4 related to chemotherapy.Results: The L3 skeletal muscle index is associated with the occurrence of grade 3~4 hematologic toxicity (leukocyte and neutropenia) in patients with diffuse large B-cell lymphoma treated with CHOP±R regimen. Those with lower L3SMI are prone to grade 3~4 hematologic toxicity.LBM is associated with the occurrence of grade 3~4 hematologic toxicity (leukopenia) in patients with diffuse large B-cell lymphoma treated with CHOP±R regimen. This with lower LBM is prone to grade 3~4 hematologic toxicity.The L3 skeletal muscle index can be used as an independent predictor of grade 3~4 hematologic toxicity (leukocyte and neutropenia) in patients with diffuse large B-cell lymphoma treated with CHOP ± R regimen. The cut-off value can be defined as 39.91 cm2/m2.Conclusion: We can draw the following conclusions:The L3 skeletal muscle index is associated with the occurrence of grade 3~4 hematologic toxicity (leukocyte and neutropenia) in patients with diffuse large B-cell lymphoma treated with CHOP±R regimen. Those with lower L3SMI are prone to grade 3~4 hematologic toxicity.LBM is associated with the occurrence of grade 3~4 hematologic toxicity (leukopenia) in patients with diffuse large B-cell lymphoma treated with CHOP±R regimen. This with lower LBM is prone to grade 3~4 hematologic toxicity.The L3 skeletal muscle index can be used as an independent predictor of grade 3~4 hematologic toxicity (leukocyte and neutropenia) in patients with diffuse large B-cell lymphoma treated with CHOP ± R regimen. The cut-off value can be defined as 39.91 cm2/m 2.
Empagliflozin Ameliorates Leukocyte – Endothelium Cell Interactions and Inflammation in Type 2 Diabetic Patients
Authors: Iannantuoni Francesca , Canet Francisco , Marañon Aranzazu Martinez de , Lopez-Domenech Sandra , Vezza Teresa , Navarro Blanca , Sola Eva , Morillas Carlos , Rocha Milagros , Victor Victor M 
Published: July 2020

Abstract
Background: SGLT2 inhibitors (iSGLT2) such as empagliflozin can reduce cardiovascular risk in patients with type 2 diabetes, but the underlying molecular mechanisms are yet to be determined. In the present study we evaluate the effects of empagliflozin on anthropometric and endocrine parameters, leukocyte-endothelium interactions, adhesion molecules and NFkB-p65 transcription factor expression. Methods: Eighteen patients with type 2 diabetes were recruited for the study. Patients received 10 mg/day of empagliflozin according to standard clinical protocols and were followed-up during a 24-week period. Anthropometric and analytical measurements were performed at baseline, 12-weeks and 24-weeks. Interactions between polymorphonuclear leukocytes and human umbilical vein endothelial cells (HUVECs), serum levels of adhesion molecules (P-selectin, VCAM-1 and ICAM-1) and NFkB-p65 protein levels were measured. Results: We observed a decrease in body weight, BMI and HbA1C levels from 12 weeks of treatment, which had become more pronounced at 24 weeks and was accompanied by a significant reduction in waist circumference, glucose, and hs-CRP levels. Leukocyte-endothelium interactions were reduced due to an enhancement of leukocyte rolling velocity from 12 weeks onwards, together with a significant decrease in leukocyte rolling flux and adhesion at 24 weeks. Accordingly, a significant decrease in ICAM-1 levels and NFkB-p65 expression were observed. Conclusions: Empagliflozin reduced leukocyte-endothelium interactions, adhesion molecules and NFkB-p65 expression in type 2 diabetic patients after 24 weeks of treatment.
The Distribution Characteristic of Microbial Aerosols Inside a Nursery Pig House and the Respiratory Tract of Piglets
Authors: Tang Qian , Huang Kai , Liu Junze , Jin Xiaoming , Li ChunMei 
Published: July 2020

Abstract
Background: The particulate matter (PM) is a carrier of many substances. Microorganisms are vital constituents contained in PM and the kinds and concentration are closely connected to human health and animal production. This study was aimed to investigate the distribution characteristics of microbial aerosols inside the pig house and as well as in the respiratory tract of pigs. The environment inside a nursery pig house was monitored in winter, including temperature, relative humidity, TSP, PM10, PM2.5, NH3, CO2, CO and NO. The concentrations of airborne culturable bacteria, fungi and Escherichia coli were detected. Then 16 S rRNA sequencing technology was applied to identify bacteria contained in different sized PM and the bacteria in the respiratory tract of piglets.Results: The results showed that the concentration of airborne culturable bacteria inside the pig house was significantly higher than that outside. The concentration of airborne culturable bacteria was reduced with the decrease of the size of PM; the concentration of airborne culturable fungi was mostly distributed in the size of 2.1-3.3 μm and 1.1-2.1 μm PM; most airborne culturable Escherichia coli were distributed in the size of >7.0 μm and 2.1-3.3 μm. Besides, these three types of microbial aerosols did not exhibit significant change during different time points. The 16 S rRNA results showed that the bacteria contained in PM had high similarity with that in the respiratory tract of pigs. The bacteria assemblage in the size of 1.1-3.3 μm PM had high similarity with that in the lower respiratory tract (bronchus and lung) of pigs. In addition, four potential pathogenic bacteria genera (Escherichia-Shigella, Streptococcus, Acinetobacter, Pseudomonas) were identified in the PM samples and the respiratory tract.Conclusions: These results will provide a significant scientific basis in exploring the potential risk of aerosol from animal houses for human and animal health.
Anti-fatigue Effects of Ginseng Antler Yam Tang Modulation of Oxidative Stress Signaling in a Mice Model
Authors: Miao Lei , Zhang Rongrong , Shao Shuai , Zhang Hongyin , Xiao Fengqin , Yi Chunguang , Zhao Daqing , yan mingming 
Published: July 2020

Abstract
Background: Ginseng Antler Yam Tang (GAYT), believe to invigorate “Qi” (vital energy), nourish “Blood” (body circulation) and engender “liquid” (body fluid), is a traditional Chinese medicine formula derived from the traditional prescription and Chinese traditional medicine partner theory. Methods: In this study, we aimed to evaluate the anti-fatigue effects of GAYT and its mechanisms are related to oxidative stress signaling using GAYT composition, in vitro and in vivo antioxidant, and biochemical index detection. Chemical components analysis of GAYT was performed by high performance liquid chromatography (HPLC) and ultraviolet spectrophotometry (UV). Results: The results show that the GAYT is rich in protein, total flavonoids, total polysaccharide and saponin. The mice model was treatment by GAYT (0.9, 1.8 and 3.6g/kg) for 4 weeks. GAYT treatment enhanced antioxidant activities. GAYT significantly enhances the exercise performance in weight-loaded swimming, rotating rod, and forced running test. Biochemical index levels showed that these effects were closely correlated with inhibiting the depletion of glycogen, blood lactic acid (LD) and adenosine triphosphate (ATP) stores, regulating oxidative stress-related parameters (superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malonaldehyde (MDA)) in serum and liver of mice. Moreover, the results show that the effects of GAYT may be related with its regulation on the activations of AMP-activated protein kinase and protein kinase B in liver of mice.Conclusions: GAYT can induce recovery from fatigue in mice via the activation of the AMPK and AKT/mTOR pathways. Provide a theoretical basis for the study of GAYT's anti-fatigue effect
Moving towards a competency-based curriculum: Information analysis of patients in geriatric and special care dentistry
Authors: Limpuangthip Nareudee , Komin Orapin , Tatiyapongpaiboon Teerawut 
Published: July 2020

Abstract
Background: There is no core competency for geriatric dentistry and special patient care (GSP) in Thailand. Therefore, the present GSP program was initially developed as a knowledge-based curriculum. The objectives of this study were to improve the present GSP program by analysing information of the patients attending the GSP clinic, and the proposed future GSP curriculum is discussed.Methods: The GSP curriculum used in 2016–2019 was reviewed. Information of the 130 patients attending the GSP clinic, and those who participated a maintenance recall was analysed. The patients were invited to participate a maintenance recall visit to have their general health and oral conditions reassessed.Results: Only 50% of the patients attended a maintenance recall to be assessed for their oral and general health. A model of the future curriculum was developed based on the patients’ information. The content descriptions and learning methods of the present GSP curriculum need modification. The oral health care for elderly and special care patients requires more extensive collaboration with multiple health professions. The program has to include more learning sites for students to gain more experience and skills, especially in managing dependent and frail elders. Conclusions: Information analysis of the targeted patients is essential to improve and transform a knowledge-based curriculum for geriatric and special patient care dentistry into a competency-based curriculum. The GSP curriculum are present as a model for other institutions to develop their own curriculum related to the oral health care of geriatric and special care patients. Oral health care in elderly and special care patients should encompass not only oral disease problems, but also behavior and social context.
The Role of M6A-related CBLL1 in the Prognosis and Immune Infiltration of Pan-cancer
Authors: Guo Qiang , Li Dan , Ji Yan-Mei , Guo Jialong 
Published: July 2020

Abstract
Background

The modification of N6-methyladenosine (m6A) plays an important role in physiology and disease progression. The relationship between the role of m6a-related gene CBLL1 in pan-carcinoma and tumor immune infiltrates has remained unknown.
Methods

To explore the expression level of CBLL1 methylation in pan-cancer in SMART database, and download mRNA expression, mutation and clinical data in UCSC database, to analyze the expression level of CBLL1, and the relationship between CBLL1 expression and clinicopathological features, prognosis, mutation and immune microenvironment in pan-cancer. CIBERSORT was used to analyze the relationship between the expression of CBLL1 and the infiltration of pan-carcinoma immune cells. The mRNA expression data of UCSC database were used to analyze the correlation between CBLL1 expression and pan-cancer immunomodulations, checkpoints and receptor molecules. Gene Set enrichment analysis (GSEA) revealed the possible mechanism of CBLL1 in the regulation of pan-cancer progression.
Results

The levels of CBLL1 methylation and mRNA expression in pan-cancer tissues were abnormal. The level of CBLL1 is related to the age, race, clinical stage and treatment effect of patients with pan-carcinoma and associated with the prognosis of patients with KIRC, LUSC, THCA, THYM, MESO, PRAD, STAD, and UVM. Univariate COX regression analysis showed that expression of CBLL1 was a risk factor for poor prognosis in patients with KICH, KIRC, LAML, THYM, KIRC, PCPG, OV, PRAD, STAD, GBM and UVM.The expression level of CBLL1 was correlated with BLCA, BRCA, COAD, LAML, LGG, LUAD, LUSC, SARC, STAD, THCA, THYM and UVM tumor mutational burden (TMB), and with ACC, BRCA, CESC, COAD, DLBC, HNSC, PRAD, READ, SARC, STAD, TGCT, THCA and UCEC microsatellite instability (MSI). The expression level of CBLL1 was correlated with pan-cancer stromal cells and immune cells. The expression of CBLL1 is related to pan-cancer immunomodulators, checkpoints and receptor molecules. GSEA found that CBLL1 may participate in the progression of pan-cancer through B cell receptor singaling pathway, mRNA binding, immunoglobulin receptor binding, Positive Regulation of cell cycle phase transition and other mechanisms.
Conclusions

CBLL1 is abnormally expressed in patients with pan-carcinoma, which is expected to be a biomarker for prognosis, mutation and immune infiltration in patients with pan-carcinoma.
High-fat diet-induced oxidative stress links increased colonisation of Lactobacillus sakei with its anti-inflammatory properties in obesity
Authors: Lee Jee-Yon , Bae Eunsoo , Kim Hwa Young , Lee Kang-Mu , Yoon Sang Sun , Lee Duk-Chul 
Published: July 2020

Abstract
Background: Obesity is one of the major public health problems related to various chronic health conditions, with steadily increasing prevalence worldwide. Lactobacillus provides various benefits to the host body; however, its role in obesity is unknown. Results: In this study, we found higher colonisation of Lactobacillus sakei species in obesity group, which in turn was related to increased reactive oxygen species (ROS) levels induced by higher fat intake. We isolated L. sakei ob4.1 strain from the faeces of one subject with obesity and compared its genetic and molecular features with those of L. sakei DSM 20017 strain. L. sakei ob4.1 showed higher catalase activity, which was regulated by oxidative stress at gene transcriptional levels. L. sakei ob4.1 maintained colon epithelial cell-adhesion ability under ROS stimulation, and live bacteria could decrease colon epithelial inflammation in a dose-dependent manner. Establishing a mouse model revealed high-fat diet-induced colon ROS to be associated with increased colonisation of L. sakei ob4.1 through catalase activity. Four-week supplementation with this strain could reduce colon inflammation effectively, though not so for body weight or ROS levels in high fat-fed mice. Conclusion: We, therefore, concluded that changes in host gut-oxidative stress levels could link high fat-induced obesity to increased colonisation of L. sakei ob4.1 , and this strain could be potent as anti-inflammatory probiotic in obese population with gut inflammation. Keywords Lactobacillus sakei; Obesity; Gut microbiome; Reactive oxygen stress; Inflammation; High fat diet
Chronic obstructive pulmonary disease in organized groups
Authors: Tаshmetovа G. T. , Liverko I. V. 
Published: July 2020

The objective: to study the prevalence of chronic obstructive pulmonary disease (COPD) in adult organized groups, to assess the structure and risk factors of its development.Subjects and methods. 3,000 people of the organized population working at various enterprises in Tashkent aged 20 to 60 years (1,400 (46.7%) women and 1,600 (53.3%) men) underwent the contemporary pulmonological screening.Results. The active pulmonological screening aimed to detect COPD among organized groups has been justified; examination of 3,000 people allowed detecting 198 (6.6%) new patients additionally to 65 cases that were already known at the time of screening. The chances of developing COPD increase with the presence of risk factors such as smoking, exposure to toxic substances and chemicals, and recurrent upper respiratory tract infections.
A legal obligation to adapt transboundary water agreements to climate change?
Authors: Jafroudi Maryam 
Published: July 2020

Abstract
Climate change disrupts the water cycle, jeopardises the security of water, food, and energy systems, and forces states to rethink water management practices to adapt to the new hydrological realities. When states share a water resource, adaptation to climate change proves to be more burdensome, especially if the resource in question is governed by a transboundary water agreement that fails to incorporate flexibility. The focus of this paper is on transboundary water basins with more than two riparian states, where only part of the co-riparian states are party to a transboundary water agreement. The paper discusses whether the recognition of the principle of equitable and reasonable use of water as a principle of customary international law creates an obligation for the party states to such agreements to adapt the terms of their arrangement to climate change. It argues that the principle of equitable and reasonable use of water establishes an obligation of conduct for the states to respect non-parties' riparian rights to a fair share of beneficial uses of water and protect the environment. Therefore, the nature of disruptions caused by climate change may make it imperative for the party states to take all possible measures that allow them to modify their water practices under an agreement to the implications of climate change in order to comply with the principle of equitable and reasonable use of water.