bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity
Authors: Fahmy Hawash Mohamed Bayoumi , Sanz-Remón Joaquin , Grenier Jean-Christophe , Kohn Jordan , Yotova Vania , Johnson Zach , Lanford Robert E. , Brinkworth Jessica F. , Barreiro Luis B. 
Published: July 2020

AbstractDespite their close genetic relatedness, apes and African and Asian monkeys (AAMs), strongly differ in their susceptibility to severe bacterial and viral infections that are important causes of human disease. Such differences between humans and other primates are thought to be a result, at least in part, of inter-species differences in immune response to infection. However, due to the lack of comparative functional data across species, it remains unclear in what ways the immune systems of humans and other primates differ. Here, we report the whole genome transcriptomic responses of ape species (human, common chimpanzee) and AAMs (rhesus macaque and olive baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ∼40% more genes than AAMs. Additionally, we find that genes involved in the regulation of inflammatory and interferon responses show the most divergent early transcriptional responses across primates and that this divergence is attenuated over time. Finally, we find that relative to AAMs, apes engage a much less specific immune response to different classes of pathogens during the early hours of infection, upregulating genes typical of anti-viral and anti-bacterial responses regardless of the nature of the stimulus. Overall, these findings suggest apes exhibit increased sensitivity to bacterial and viral immune stimulation, activating a broader array of defense molecules that may be beneficial for early pathogen killing at the potential cost of increased energy expenditure and tissue damage.
Cohesin mutations are synthetic lethal with stimulation of WNT signaling
Authors: Chin Chue Vin , Antony Jisha , Ketharnathan Sarada , Gimenez Gregory , Parsons Kate M. , He Jinshu , George Amee J. , Braithwaite Antony , Guilford Parry , Hannan Ross D. , Horsfield Julia A. 
Published: July 2020

AbstractMutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21 and STAG2 and screened for synthetic lethality with 3,009 FDA-approved compounds. The screen identified several compounds that interfere with transcription, DNA damage repair and the cell cycle. Unexpectedly, one of the top ‘hits’ was a GSK3 inhibitor, an agonist of Wnt signaling. We show that sensitivity to GSK3 inhibition is likely due to stabilization of β-catenin in cohesin mutant cells, and that Wnt-responsive gene expression is highly sensitized inSTAG2-mutant CMK leukemia cells. Moreover, Wnt activity is enhanced in zebrafish mutant for cohesin subunitrad21. Our results suggest that cohesin mutations could progress oncogenesis by enhancing Wnt signaling, and that targeting the Wnt pathway may represent a novel therapeutic strategy for cohesin mutant cancers.
Distributional challenges regarding data on death and incidences during the SARS-CoV-2 pandemic up to July 2020
Authors: Manz Kirsi , Mansmann Ulrich 
Published: July 2020

ABSTRACTCOVID-19 is a major global crisis with unpredictable consequences. Many scientists have struggled to make forecasts about its impact. Especially, appropriate preparations for a second wave are needed not to move in a costly panic mode again. It is necessary to get ideas about worst case scenarios regarding incidences, hospitalization, or use of ICU resources. They can be described in terms of extreme quantiles (95%, 99%, 99.9%) of specific distributions that supposedly formalize the data mechanism behind future observations.Therefore, distributional issues do matter. Cirillo and Taleb argue that a natural and empirically correct framework for assessing and managing real risk in pandemics is provided by extreme value theory dealing with extrema and not averages. We explore this idea in more detail.In this paper we discuss the fat-tail patterns in the distribution of the global COVID-19 data by analyzing data from 66 countries worldwide. We also explore their relevance at a lower, regional scale perspective (national, federal state), which is in our opinion more relevant for planning measures against the epidemic spread. For this we analyze data from the German federal state of Bavaria.We conclude that fat-tail patterns are seen in global data, possibly reflecting the respective heterogeneity between different countries regarding incidences and fatalities during the ongoing epidemic. However, the disease activity at regional level seems to be better described by classical Poisson based models. To bridge the gap between regional and global phenomena we refer to mixtures of slim-tail distributions that may create fat-tail features.Especially in the beginning of a pandemic acting according to the “better safe than sorry” principle and taking extreme forecasts as the basis for the decisions might be justified. However, as the pandemic continues and control measures are partially lifted, there is a need for a careful discussion how to choose relevant distributions and their respective quantiles for future resource planning in order not to cause more harm as the pandemic itself.
Poly[[[μ-trans-1,2-bis(pyridin-4-yl)ethene-κ2N:N′]-μ-iodido-copper(I)]–trans-1,2-bis(pyridin-4-yl)ethene (1/0.25)]
Authors: Hoffman Jessica L. , Akhigbe Jessie E. , Reinheimer Eric W. , Smucker Bradley W. 
Published: July 2020

The title compound, {[CuI(bpe)]·0.25(bpe)}n, was synthesized similarly to (CuI)2(bpe) [Nealet al.(2019).IUCrData,4, x190122] with red crystals grown from acetonitrile solutions of CuI and the bpe ligand [bpe = 1,2-bis(pyridin-4-yl)ethene, C12H10N2]. The structure of the title compound is a type 1 complex in the Graham nomenclature [Grahamet al.(2000).Inorg. Chem.39, 5121–5132], having rhombic dimers of Cu2I2that are bridged by two bpe ligands, to form oligomeric ribbons arranged as stairsteps. The step height is 2.8072 (11) Å, which is the Cu—Iidistance of the dimer [symmetry code (i): 1 − x, 2 − y, 1 − z]. The resulting polymer displays a two-dimensional honeycomb framework along the (01\overline1) plane, and disordered free bpe molecules fill the voids in the crystal.
Experiential marketing, brand image and brand loyalty: a case study of Starbucks
Authors: Chang Wen-Jung 
Published: July 2020

PurposeDue to the internationalization that has occurred during the past few decades, the living conditions of people around the island of Taiwan have gradually changed, especially their eating habits. Among them, the growth of the coffee market has been very significant. To date, many studies have been devoted to exploring the application of experiential marketing (EM) in a variety of industries. Many experimental results have proven that a positive brand image (BI) will lead to brand loyalty (BL). In services, the best at the practice of EM is Starbucks. Therefore, this paper aims to assess the role of BI in EM and BL for Taiwan’s most popular brand, Starbucks.Design/methodology/approachIn the formal test stage, 225 questionnaires were given to respondents in Starbucks located in four districts (Da-An, Zhong-Zheng, Nei-Hu and Xi-Yin), which have many more stores than the other districts in Taipei City. Two hundred valid samples were obtained. This study used structural equation modelling (SEM) to validate the relationships among EM, BI and BL.FindingsThe findings show that EM cannot directly impact BL as expected, as it needs BI to do so. In other words, BI acts a complete mediator in the relationship between EM and BL.Practical implicationsIn this study, BI acts a complete mediator. This means that if Starbucks expects to improve consumers’ loyalty to the brand, it only needs to rely on the good overall image of the brand. Facing such business style homogeneity, people need some available information to help them to execute their following purchase decisions. Though Starbucks can bring me to its locations, meaning that Starbucks has made its first move in comparison with other competitors, I still decide to leave without any impressive image of this brand. Accordingly, we can refer to BI as a powerful endorsement of a qualified relationship between EM and BL.Originality/valueCompared to past studies on Taiwan’s/Taipei’s Starbucks, this paper simultaneously inputs EM, BI and BL into the model. Though Starbucks has achieved great EM success, this study finds that EM is no longer exclusive to BL, and BI is a powerful endorsement of a qualified relationship between EM and BL. For Starbucks, it must strengthen consumer perceptions of its BI to create customer loyalty.
Prioritizing resilient capability factors of dealing with supply chain disruptions: an analytical hierarchy process (AHP) application in the textile industry
Authors: Piprani Arsalan Zahid , Jaafar Noor Ismawati , Mohezar Ali Suhana 
Published: July 2020

PurposeThe purpose of the study is to determine and prioritize the resilient capability factors at different stages of supply chain disruptions in Pakistan's textile industry.Design/methodology/approachThe study employs a two-stage methodology. In the first stage, the extant literature was reviewed, and based on that, experts' panel consultations were conducted to identify the resilient capability factors at the different stages of supply chain. In the second stage, analytical hierarchy process (AHP) methodology was used to rank the resilient capability factors needed in Pakistan's textile industry.FindingsThe results show that building an integrated supply chain ranking is one of the most critical practices in bolstering supply chain resilience. The results also reveal that firms should focus on the readiness phase of resilience as it is categorized as the most important phase.Practical implicationsThe findings of the study provide supply chain professionals with a clear consideration of the critical factors that are needed to build supply chain resilience. From an industry-specific perspective, the study offers guidelines on what resilient capability factors should be regarded as critical when implementing resilient capabilities in order to reduce the negative impacts of disruptions.Originality/valueThe study is among the first studies in prioritizing the resilient capability factors at different phases of supply chain disruptions. The study would provide further opportunities for future researchers in using other multicriteria decision-making tools.
Experimental and numerical investigations of dynamic strain ageing behaviour in solid solution treated Inconel 718 superalloy
Authors: Song Run-Hua , Qin Hai-Long , Bi Zhong-Nan , Zhang Ji , Chi Hai , Busso Esteban P , Li Dong-Feng 
Published: July 2020

Purpose
The purpose of this paper is to systematically investigate the dynamic strain aging (DSA) effect in solid solution treated IN718 at different temperatures through experiments and simulations to gain an understanding of the inelastic deformation mechanisms.

Design/methodology/approach
In the present work, uniaxial tensile tests have been carried out in conjunction with finite element (FE) simulations to investigate the behaviour of the solid solution treated Inconel 718 superalloy at different temperatures and strain rates. Dynamic strain aging (DSA) effects, which manifested during the tests in the form of a negative strain rate sensitivity and stress serrations, are investigated. The most significant DSA effect occurs at 500°C and at a strain rate of 10–4 s-1. In a newly proposed rate-dependent constitutive formulation, the DSA model, proposed by McCormick, Kubin and Estrin, was introduced into slip-assisted solute hardening, and an activation energy-dependent exponential flow rule was adopted.

Findings
The observed negative strain rate sensitivity and stress serrations are well predicted by a 3 D FE. The FE results indicate that the equivalent plastic strain rate distribution in the specimen gauge length is as highly inhomogeneous as in the other materials exhibiting DSA effects such as aluminium and titanium alloy. During inelastic deformation, propagating high strain rate bands can be closely correlated to the stress serrations.

Originality/value
For the DSA effect in solid solution treated IN718, the existing researching mainly focuses on the mechanical properties experiment and microstructure observation. In this study, a constitutive formulation, combined with the DSA model, has been proposed, and the mechanical behaviors, including the DSA effect, have been well predicted by a finite element model.
Performance management on the shop floor – an investigation of KPI perception among managers and employees
Authors: Ohlig Jasmin , Hellebrandt Thomas , Metzmacher Amelie I. , Pötters Patrick , Heine Ina , Schmitt Robert H. , Leyendecker Bert 
Published: July 2020

PurposeThe purpose of this paper is to investigate the application of key performance indicators (KPIs) on shop floor level in German small- and medium-sized enterprises (SMEs). The paper focuses on the examination of perception differences between shop floor employees and managers with regard to collection, calculation and consolidation of KPIs as well as visualization and motivational aspects.Design/methodology/approachTo examine the hypothesis on differing perceptions regarding KPIs, 27 qualitative interviews with shop floor employees and production managers within 6 SMEs from the German machinery and equipment industry were conducted on basis of a semi-structured guideline.FindingsThe findings show that shop floor employees self-assess a lack of relevant knowledge when it comes to understanding KPIs. Moreover, the results show that shop floor employees perceive the visualization of shop floor KPIs as insufficient and non-motivational. This goes along with the finding that managers are aware of the lacking benefit of KPIs resulting from the rather negative perception of shop floor employees. The interviewed managers recognize a strong potential for improvement of their KPI systems.Originality/valueThe interview results confirm the need to design a performance management system on the shop floor that considers and aligns both management and operations, is directed to the shop floor level, considers explicitly the perspective of employees and integrates motivational elements.
IoT sensors management system using Agile-Kanban and its application for weather measurement and electric wheelchair management
Authors: Matsuo Keita , Barolli Leonard 
Published: July 2020

Purpose
Recently, Internet of Things (IoT) devices and sensors are rapidly increasing in the word. They are connecting to the internet and are generating vast packets in the network. Thus, the networks could be congested, and the performance will degrade. For this reason, it is important to decrease the number of transmitted packets. Agile is a technique to develop the software and manage the work efficiently. Kanban is a method to support Agile development. The purpose of this paper is to propose an IoT sensors management system considering Agile–Kanban and show its application for weather measurement and electric wheelchair management.

Design/methodology/approach
The authors present the design and implementation of two systems and show the measurement device, data communication failure and experimental results.

Findings
The proposed Agile–Kanban system can manage a large amount of IoT sensors and can decrease the IoT sensor’s consumption power thus increasing the IoT sensor lifetime.

Originality/value
By experimental results, the authors have shown that the proposed systems have good performance and can control the IoT devices efficiently.
Evaluation of critical operations capabilities for competitive manufacturing in a high-cost environment
Authors: Sansone Cinzia , Hilletofth Per , Eriksson David 
Published: July 2020

Purpose
To survive in a competitive landscape, companies are required to identify, develop and continuously improve upon the operations capabilities that have the greatest impact on the overall competitiveness. This paper aims to evaluate critical operations capabilities for competitive manufacturing in a high-cost environment.

Design/methodology/approach
Critical operations capabilities for competitive manufacturing were extracted in a literature review and then evaluated from the perspective of a high-cost environment in a focus group study. The focus group included a quantitative (questionnaire) and qualitative (discussion) evaluation of the extracted critical operations capabilities.

Findings
The empirical findings revealed that all the capabilities identified in the literature review are considered critical in a high-cost environment, albeit with varying emphasis. Companies located in a high-cost environment tend to emphasize a broad set of capabilities related to quality, cost, time, flexibility and innovation rather than only cost-related capabilities.

Research limitations/implications
The research is based on a focus group that was limited to 14 representatives from five Swedish manufacturing companies. This can reveal some limitations with regard to the generalizability of the conclusions drawn. Hence, this research should be considered as an initial step in gaining a more in-depth and complete understanding of the research topic under investigation.

Practical implications
The research outcome enables managers to design their operations strategy more systematically and effectively, to be consistent with their targeted capabilities. The operations capabilities are important for both the company’s competitiveness and its future direction.

Originality/value
The paper presents an updated understanding of how companies achieved a competitive advantage in a specific manufacturing environment such as a high-cost context. It additionally provides an overview of what capabilities are developed for implementing successful operations strategies.
Awareness, attitude and practises of biomedical waste management amongst public health-care staff in Karnataka, India
Authors: Golandaj Javeed Ahamed , Kallihal Karabasappa Gadigeppa 
Published: July 2020

Purpose
Enormous amount of biomedical wastes (BMW) produced everyday across the world. Management of BMW depends on adherence to protocol. BMW management at generation point, definitely, depends upon the awareness, attitudes and practises of health-care staff, the purpose of this study will assess the awareness, attitude and practise regarding different aspects of BMW.

Design/methodology/approach
An observational with appropriate checklists, and a cross-sectional study, involving questionnaires, was conducted during 7-24 January 2016. The existing system of BMW management, funds, resources, etc., knowledge, attitude and practises about BMW were assessed amongst 273 health-care workers in selected public health-care institutes of Karnataka.

Findings
Of 273 study participants, majority (54%) of them have not received any training pertaining to BMW. The results showed a poor level of knowledge and awareness of BMW management amongst health-care personnel. Merely, 43% of the participants correctly knew the categorization of BMW and its disposal in proper colour-coded bins/bags. Awareness is very poor amongst the lower age group, male participants, lab-technicians/pharmacists and supporting staff. Doctors were good at theoretical knowledge such as rules, legislation and public-health importance of BMW management than the practical aspects such as categorization and colour-coding. Further, the attitude of health-care staff is favourable about BMW. Immunization for hepatitis-B was very poor amongst waste handlers (43%).

Originality/value
As the awareness and practise regarding BMW management were poor across different health-care staff there is a need to conduct periodic training and regular monitoring with special focus on the proper use of personal protective equipment. Further, precautionary immunization should be provided, especially waste handlers and sanitary workers.
Will this search end up with booking? Modeling airline booking conversion of anonymous visitors
Authors: Lee Misuk 
Published: July 2020

Purpose
Over the past two decades, online booking has become a predominant distribution channel of tourism products. As online sales have become more important, understanding booking conversion behavior remains a critical topic in the tourism industry. The purpose of this study is to model airline search and booking activities of anonymous visitors.

Design/methodology/approach
This study proposes a stochastic approach to explicitly model dynamics of airline customers’ search, revisit and booking activities. A Markov chain model simultaneously captures transition probabilities and the timing of search, revisit and booking decisions. The suggested model is demonstrated on clickstream data from an airline booking website.

Findings
Empirical results show that low prices (captured as discount rates) lead to not only booking propensities but also overall stickiness to a website, increasing search and revisit probabilities. From the decision timing of search and revisit activities, the author observes customers’ learning effect on browsing time and heterogeneous intentions of website visits.

Originality/value
This study presents both theoretical and managerial implications of online search and booking behavior for airline and tourism marketing. The dynamic Markov chain model provides a systematic framework to predict online search, revisit and booking conversion and the time of the online activities.
Leader knowledge sharing behavior and follower creativity: the role of follower acquired knowledge and prosocial motivation
Authors: Thuan Le Cong , Thanh Bui Thi 
Published: July 2020

PurposeAlthough leaders play a vital role in motivating the creative performance of followers, a paucity of research has examined specific behaviors of leaders. The purpose of this paper is to investigate the impact of leader knowledge sharing behavior on followers’ creative performance.Design/methodology/approachTo decrease the potential of the common method bias, this research conducted a time-lagged study to gather data from 319 employees working at information technology companies in Vietnam. This study used the hierarchical regression analysis to test the hypotheses.FindingsThe results showed that leader knowledge sharing behavior had a positive impact on follower creativity. Moreover, follower-acquired knowledge partially mediated this relationship. Furthermore, follower prosocial motivation positively moderated the effects of leader knowledge sharing behavior and follower-acquired knowledge on followers’ creative performance.Originality/valueThe findings contribute to the creativity literature by providing evidence that leader knowledge sharing behavior could stimulate follower creativity directly and indirectly through follower-acquired knowledge. This research also confirmed the moderating role of prosocial motivation in reinforcing the influence of leader behaviors and employee ability on employee creativity.