bluuebunny/crossref_metadata_2025_split huggingface dataset:
When machines think for us: the consequences for work and place
Authors: Clifton Judith , Glasmeier Amy , Gray Mia 
Published: January 2020

AbstractThe relationship between technology and work, and concerns about the displacement effects of technology and the organisation of work, have a long history. The last decade has seen the proliferation of academic papers, consultancy reports and news articles about the possible effects of Artificial Intelligence (AI) on work—creating visions of both utopian and dystopian workplace futures. AI has the potential to transform the demand for labour, the nature of work and operational infrastructure by solving complex problems with high efficiency and speed. However, despite hundreds of reports and studies, AI remains an enigma, a newly emerging technology, and its rate of adoption and implications for the structure of work are still only beginning to be understood. The current anxiety about labour displacement anticipates the growth and direct use of AI. Yet, in many ways, at present AI is likely being overestimated in terms of impact. Still, an increasing body of research argues the consequences for work will be highly uneven and depend on a range of factors, including place, economic activity, business culture, education levels and gender, among others. We appraise the history and the blurry boundaries around the definitions of AI. We explore the debates around the extent of job augmentation, substitution, destruction and displacement by examining the empirical basis of claims, rather than mere projections. Explorations of corporate reactions to the prospects of AI penetration, and the role of consultancies in prodding firms to embrace the technology, represent another perspective onto our inquiry. We conclude by exploring the impacts of AI changes in the quantity and quality of labour on a range of social, geographic and governmental outcomes.
Incidence, prevalence and crude survival of patients starting dialysis in Portugal (2010–16): analysis of the National Health System individual registry
Authors: de Almeida Edgar A F , Raimundo Mário , Coelho Anabela , Sá Helena 
Published: January 2020

Abstract

Background
The Portuguese Society of Nephrology (PSN) reported that Portugal has one of the highest incidences of dialysis in Europe. However, this claim was based on aggregated data supplied by dialysis providers, hampering comparisons between countries. In 2009, an individual registry of patients starting dialysis was set up by the Portuguese Ministry of Health. We analysed individual data of patients starting dialysis from January 2010 until December 2016.

Methods
Demography, starting treatment day, modality, regional distribution and outcomes, such as death, recovery of renal function, transfer to renal transplantation, peritoneal dialysis or conservative management, were extracted. Incidence, prevalence and survival analysis were calculated and compared with the PSN registry.

Results
Out of 19 190 registrations, 16 775 were incident patients (61.8% men). Yearly incidence of renal replacement therapy was 250, 248, 229, 239, 230, 231 and 244 per million population (p.m.p.) for 2010 to 2016, compared with 235, 224, 218, 230, 234, 225 and 239 p.m.p. reported by the PSN registry. On the other hand, prevalence increased from 998 p.m.p. in 2010 to 1286 p.m.p. in 2016, compared with 1010 p.m.p. in 2010 increasing to 1203 p.m.p. in 2016 from the PSN registry. The regions of Alentejo (122.9 p.m.p.) and the the Centre (160.8 p.m.p.) had the lowest regional incidence, while Lisbon had the highest (386 p.m.p. in 2016). Unadjusted survival analysis revealed that 93.5% of the patients were alive on the 91st day, whereas 85.2 and 78.3% were alive at 1 and 2 years, respectively. Crude survival at 7 years was 40%.

Conclusions
For the first time, an individual registry of patients starting dialysis in Portugal was subject to analysis and added new information about long-term survival and regional differences in the incidence and prevalence of renal replacement therapy. We were able to confirm that Portugal has one of the world’s highest incidences and prevalences of dialysis. We also demonstrate, for the first time, a striking regional difference in the incidence of dialysis and an excellent early and long-term survival of patients on dialysis. These results compare well with other European countries in terms of the dialysis efficiency.
Strengthening of banana breeding through data digitalization
Authors: Vignesh Kumar B , Backiyarani S , Chandrasekar A , Saranya S , Ramajayam D , Saraswathi M S , Durai P , Kalpana S , Uma S 
Published: January 2020

AbstractImprovement of edible bananas (a triploid and sterile crop) through conventional breeding is a challenging task owing to its recalcitrant nature for seed set, prolonged crop duration. In addition, the need of huge man power at different stages of progeny development and evaluation often leads to mislabeling, poor data management and loss of vital data. All this can be overcome by the application of advanced information technology source. This ensured secure and efficient data management such as storage, retrieval and data analysis and further could assist in tracking the breeding status in real time. Thus, a user-friendly web-based banana breeding tracker (BBT) has been developed using MySQL database with Hypertext Preprocessor (PHP). This BBT works on all operating systems with access to multiple users from anywhere at any time. Quick responsive (QR) code labels can be generated by the tracker, which can be decoded using QR scanner. Also for each and every updated progress in breeding stages, a new QR code can be generated, which in turn reduce labeling errors. Moreover, the tracker has additional tools to search, sort and filter the data from the data sets for efficient retrieval and analysis. This tracker is being upgraded with phenotypic and genotypic data that will be made available in the public domain for hastening the banana improvement program.
Cohort Trends in Working Life Expectancies at Age 50 in the United States: A Register-Based Study Using Social Security Administration Data
Authors: Dudel Christian , Myrskylä Mikko 
Published: January 2020

Abstract

Objectives
Little is known about the length of working life, even though it is a key indicator for policy-makers. In this paper, we study how the length of working life at age 50 has developed in the United States from a cohort perspective.

Methods
We use a large longitudinal sample of U.S. Social Security register data that covers close to 1.7 million individuals of the cohorts born from 1920 to 1965. For all of these cohorts, we study the employment trajectories and working life expectancy (WLE) at age 50 by gender and nativity (native-born/foreign-born). For the cohorts with employment trajectories that are only incompletely observed, we borrow information from older cohorts to predict their WLE.

Results
The length of working life has been increasing for the native-born males and females, and the younger cohorts worked longer than the older cohorts. However, WLE might soon peak, and then stall. The gap in WLE between the native-born and the foreign-born has increased over time, although latter group might be able to catch up in the coming years.

Discussion
Our ﬁndings show that studying employment from a cohort perspective reveals crucial information about patterns of working life. The future development of the length of working life should be a major concern for policy-makers.
Refgenie: a reference genome resource manager
Authors: Stolarczyk Michał , Reuter Vincent P , Smith Jason P , Magee Neal E , Sheffield Nathan C 
Published: January 2020

Abstract

Background
Reference genome assemblies are essential for high-throughput sequencing analysis projects. Typically, genome assemblies are stored on disk alongside related resources; e.g., many sequence aligners require the assembly to be indexed. The resulting indexes are broadly applicable for downstream analysis, so it makes sense to share them. However, there is no simple tool to do this.

Results
Here, we introduce refgenie, a reference genome assembly asset manager. Refgenie makes it easier to organize, retrieve, and share genome analysis resources. In addition to genome indexes, refgenie can manage any files related to reference genomes, including sequences and annotation files. Refgenie includes a command line interface and a server application that provides a RESTful API, so it is useful for both tool development and analysis.

Conclusions
Refgenie streamlines sharing genome analysis resources among groups and across computing environments. Refgenie is available at https://refgenie.databio.org.
Substantive and Procedural Criminal Law Protection of Human Rights in the Law of the European Convention on Human Rights
Authors: Kamber Krešimir 
Published: January 2020

Abstract
This article seeks to examine and explain the interaction between the substantive and procedural aspects of criminal law protection of human rights in the law of the European Convention of Human Rights. Noting certain theoretical and conceptual lacunae that arise in this context, the article suggests the most appropriate solution for the assessment of the substantive-procedural relationship from the perspective of legal theory and the European Court of Human Rights’ case-law. It submits, in particular, that it is always necessary to examine both aspects—substantive and procedural—of the same right and that the procedural aspect should be given primacy both in terms of the order of examination and inferences to be drawn on the question of observance of human rights by states.
Analysis of the susceptible-infected-susceptible epidemic dynamics in networks via the non-backtracking matrix
Authors: Masuda Naoki , Preciado Victor M , Ogura Masaki 
Published: January 2020

AbstractWe study the stochastic susceptible-infected-susceptible model of epidemic processes on finite directed and weighted networks with arbitrary structure. We present a new lower bound on the exponential rate at which the probabilities of nodes being infected decay over time. This bound is directly related to the leading eigenvalue of a matrix that depends on the non-backtracking and incidence matrices of the network. The dimension of this matrix is $N+M$, where $N$ and $M$ are the number of nodes and edges, respectively. We show that this new lower bound improves on an existing bound corresponding to the so-called quenched mean-field theory. Although the bound obtained from a recently developed second-order moment-closure technique requires the computation of the leading eigenvalue of an $N^2\times N^2$ matrix, we illustrate in our numerical simulations that the new bound is tighter, while being computationally less expensive for sparse networks. We also present the expression for the corresponding epidemic threshold in terms of the adjacency matrix of the line graph and the non-backtracking matrix of the given network.
Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but Not Phagocytosis
Authors: Gilmartin Allissia A , Ralston Katherine S , Petri William A 
Published: January 2020

Abstract

Background
Entamoeba histolytica kills human cells by ingesting fragments of live cells until the cell eventually dies, a process termed amebic trogocytosis. In a previous study, we showed that acidified amebic lysosomes are required for both amebic trogocytosis and phagocytosis, as well as cell killing.

Methods
Amebic cysteine proteases (CPs) were inhibited using an irreversible inhibitor, E-64d.

Results
Interfering with amebic CPs decreased amebic trogocytosis and amebic cytotoxicity but did not impair phagocytosis.

Conclusions
We show that amebic CPs are required for amebic trogocytosis and cell killing but not phagocytosis. These data suggest that amebic CPs play a distinct role in amebic trogocytosis and cell killing.
Genocide in Sudan as Colonial Ecology
Authors: Wise Louise 
Published: January 2020

AbstractThis article presents a novel theoretical and empirical account of the genesis and constitution of genocide in Sudan. To do so, it brings developments in critical genocide studies, notably the colonial and international “turns” and renewed attention to the scholarship of Lemkin, into dialogue with theoretical arguments about processual ontologies, complexity theory, and assemblage thinking. The latter provide a conceptual vocabulary to rethink the kind of ontological phenomenon that genocide constitutes. Rather than a discrete outcome or temporally and geographically bounded “event,” genocide in Sudan is seen as a heterogeneous, process-based, systemic entity. Challenging conventional genocide models generally and dominant narratives about Sudan specifically, the article argues that genocide in Sudan should be conceptualized as an historical internal frontier-based pattern that is constituted by three intersecting colonial forms: postcolonialism, internal colonialism, and neocolonialism. In doing so, it suggests a new way of thinking about the genocide-colonialism nexus. Tracing these three colonialisms, genocide appears not as an aberrant breakdown, violent outburst, or top-down ideological “master plan.” Neither is it a single, linearly unfolding process. Rather, it is emergent from a colonial ecology, its logic and potentiality imbricated with, and incipient within, a temporally and geographically expansive web of actors, processes, structures, relations, discourses, practices, and global forces.
In Search of Normality for Vitamin K1: Establishing Age-Dependent Reference Intervals in the Danish Population
Authors: Boegh Andersen Ida , Brasen Claus Lohman , Schmedes Anne , Brandslund Ivan , Madsen Jonna Skov 
Published: January 2020

Abstract

Background
A growing body of evidence suggests that vitamin K has beneficial effects on human health, especially cardiovascular and bone health. Vitamin K1 (phylloquinone), the predominant form of vitamin K in blood, is regarded as an indicator of vitamin K status, but to our knowledge no reference intervals (RIs) have been established for vitamin K1.

Methods
In this population-based study, vitamin K1 was measured in serum from 3808 Caucasian individuals without diabetes from 26 to 78 years of age. The need for gender- and age-partitioned vitamin K1 reference intervals was evaluated using Lahti’s method, and exclusion criteria were defined to obtain as healthy a study group as possible. The excluded subgroups were tested for differences in mean serum vitamin K1 levels. Serum vitamin K1 levels were quantified using an in-house newly developed, validated, and highly sensitive online SPE-LC-MS/MS method with a limit of quantitation of (LOQ) 0.05 nmol/L.

Results
The reference interval for serum vitamin K1 was 0.22 to 3.95 nmol/L for individuals aged 26 to 44 years and 0.35 to 3.70 nmol/L for individuals aged 45 to 78. Similar age-specific reference intervals were established for vitamin K1-triglyceride ratio being 0.20 to 3.16 and 0.31 to 3.44, respectively. No significant difference was found between genders. Serum vitamin K1 was detectable in all serum samples. Individuals with known comorbidity were found to have significantly lower serum vitamin K1 compared to those without comorbidity. Current smokers had lower serum vitamin K1 compared to nonsmokers.

Conclusion
Age-dependent reference intervals were established for serum vitamin K1 and vitamin K1-triglyceride ratio in a well-defined, healthy Caucasian population. Lower serum vitamin K1 levels were found in individuals with known comorbidity, suggesting an association between serum vitamin K1 and disease status. Further studies are needed to determine an optimal serum vitamin K1 level.
Lack of interactive effects between diet composition and acid addition with drying method on amino acid digestibility values in porcine ileal digesta
Authors: Kerr Brian J , Curry Shelby M , Ramirez Brett C 
Published: January 2020

Abstract
Two experiments were conducted to determine the effect of oven drying (OD) or freeze drying (FD) on apparent ileal digestibility (AID) of AA in diets fed to pigs. In experiment 1, 15 barrows (88.4 ± 6.4 kg) were allotted to either a corn starch–soybean meal (CST), potato starch–soybean meal (PST), or corn–soybean meal (CSBM) diet, over 2 collection periods. Following collection, samples were pooled within pig and subdivided into either OD or FD, resulting in 10 observations per diet by drying-method combination. In experiment 2, 11 barrows (63.3 ± 3.8 kg) were fed a CST diet, and, following collection, samples were pooled within pig and subdivided and either adjusted to pH 4 or remain unadjusted. Subsets of these samples were then subdivided to be either FD or OD, resulting in 11 observations per pH level by drying-method combination. OD was accomplished by drying samples in a forced air oven at either 100 °C (experiment 1) or 75 °C (experiment 2). In experiment 1, there was no diet type by drying-method interactions noted for any of the AA (P &gt; 0.10).OD resulted in a higher AID of AA compared with samples which were FD (P ≤ 0.10), for all AA except for Gly and Tyr. Averaged across all AA, AID of AA was 3.3% greater if the sample was OD compared with FD. Differences in AID of AA among the 3 diets were noted for all AA (P ≤ 0.07), except for Cys (P = 0.33), due to the fact that CST and PST diets only contained soybean meal (SBM) as an AA-providing ingredient while the CSBM diet contained both corn and SBM. Pigs fed the PST diet had greater SID for all AA compared with pigs fed the CST diet (P ≤ 0.05), except for His, Lys, Cys, and Glu. In experiment 2, there were no pH-adjustment by drying-method interactions noted on AID for any of the AA (P &gt; 0.10). Adjusting ileal digesta to a pH of 4.0 had little effect on AID for most of the AA, except for a lowered AID of Arg, His, Lys, Trp, and Ser (P ≤ 0.10). OD resulted in a higher AID for all AA (P ≤ 0.09) except for Ile, Thr, Val, Ala, Asp, Glu, and Gly. Averaged across all AA, the increase in AID of AA was 1.7% greater if the sample was OD compared with FD. On average, OD of ileal digesta resulted in a 2.5% greater estimate of AID of AA compared with samples that were FD, and was not diet-, pH-, or AA-dependent. Because the majority of the data on AA digestibility are based on FD, a bias factor may be necessary to adjust AA digestibility data obtained on an OD-basis relative to an FD-basis for use in feed formulation.
Characteristics and outcomes of RET-rearranged Korean non-small cell lung cancer patients in real-world practice
Authors: Lee Jiyun , Ku Bo Mi , Shim Joon Ho , La Choi Yoon , Sun Jong-Mu , Lee Se-Hoon , Ahn Jin Seok , Park Keunchil , Ahn Myung-Ju 
Published: January 2020

Abstract

Objective
Since the first discovery of rearranged during transfection (RET) fusion in lung adenocarcinoma in 2011, two tyrosine kinase inhibitors, namely vandetanib and cabozantinib, are currently available. Despite favorable outcomes in systemic control, the intracranial therapeutic response remains insufficient. In this study, the clinical characteristics and outcomes of non-small cell lung cancer (NSCLC) patients with RET rearrangements were analyzed.

Methods
Patients with NSCLC harboring RET fusion who received treatment between January 2006 and January 2018 were analyzed. RET rearrangement was identified by FISH or NGS.

Results
A total of 59 patients were identified. About half of the patients were female (47.5%) and never smokers (50.9%). Most patients had adenocarcinoma (89.8%). A total of 17 patients (28.8%) had an intracranial lesion at the initial diagnosis of stage IV disease, and 11 additional patients (18.6%) developed intracranial metastases during follow-up. The median time to development of intracranial metastases was 19.0 months (95% CI: 9.6–28.5), resulting in a &gt;60% cumulative incidence of brain metastasis at 24 months. The systemic efficacy of pemetrexed-based regimens was favorable with progression-free survival of 9.0 (95% CI: 6.9–11.2) and OS of 24.1 (95% CI: 15.2–33.0) months. The median progression-free survival for vandetanib and immunotherapy was 2.9 (95% CI: 2.0–3.8) and 2.1 (95% CI: 1.6–2.6) months, respectively.

Conclusions
Given the likelihood of RET-rearranged NSCLC progressing to intracranial metastases and the absence of apparent clinical benefit of currently available targeted or immunotherapeutic agents, development of novel treatment with higher selectivity and better penetration of the blood–brain barrier remains a priority.
Disparities of National Lung Cancer Screening Guidelines in the US Population
Authors: Han Summer S , Chow Eric , ten Haaf Kevin , Toumazis Iakovos , Cao Pianpian , Bastani Mehrad , Tammemagi Martin , Jeon Jihyoun , Feuer Eric J , Meza Rafael , Plevritis Sylvia K 
Published: January 2020

Abstract

Background
Current US Preventive Services Task Force (USPSTF) lung cancer screening guidelines are based on smoking history and age (55–80 years). These guidelines may miss those at higher risk, even at lower exposures of smoking or younger ages, because of other risk factors such as race, family history, or comorbidity. In this study, we characterized the demographic and clinical profiles of those selected by risk-based screening criteria but were missed by USPSTF guidelines in younger (50–54 years) and older (71–80 years) age groups.

Methods
We used data from the National Health Interview Survey, the CISNET Smoking History Generator, and results of logistic prediction models to simulate lifetime lung cancer risk-factor data for 100 000 individuals in the 1950–1960 birth cohorts. We calculated age-specific 6-year lung cancer risk for each individual from ages 50 to 90 years using the PLCOm2012 model and evaluated age-specific screening eligibility by USPSTF guidelines and by risk-based criteria (varying thresholds between 1.3% and 2.5%).

Results
In the 1950 birth cohort, 5.4% would have been ineligible for screening by USPSTF criteria in their younger ages but eligible based on risk-based criteria. Similarly, 10.4% of the cohort would be ineligible for screening by USPSTF in older ages. Notably, high proportions of blacks were ineligible for screening by USPSTF criteria at younger (15.6%) and older (14.2%) ages, which were statistically significantly greater than those of whites (4.8% and 10.8%, respectively; P &lt; .001). Similar results were observed with other risk thresholds and for the 1960 cohort.

Conclusions
Further consideration is needed to incorporate comprehensive risk factors, including race and ethnicity, into lung cancer screening to reduce potential racial disparities.
Selection of patients with left breast cancer for IMRT with deep inspiration breath-hold technique
Authors: CHANG Chih-Shen , CHEN Chia-Hsin , LIU Kuo-Chi , HO Chia-Sheng , CHEN Miao-Fen 
Published: January 2020

Abstract
The deep inspiration breath-hold (DIBH) technique has been utilized to reduce the cardiac dose in left-sided breast cancer (BC) patients undergoing radiotherapy. Further investigation of the parameters for selecting which patients will benefit most from DIBH is essential. We performed dosimetric comparisons for 21 patients with left-sided BC who had both computed tomography (CT)-based free-breathing (FB) and DIBH plans. The doses to the heart and left anterior descending artery (LAD) and any reduction due to the DIBH technique were analysed. Based on CTFB plans, dosimetric analysis revealed that the irradiation doses to the heart and LAD were significantly correlated with the target volume, the ipsilateral lung volume (ILV) and the total lung volume (TLV). When patients had an ILV ≥ 950 cm3 or a TLV ≥ 2200 cm3, the irradiation doses to the heart and LAD were significantly decreased. Furthermore, the reduction in the mean heart dose (MHD) was correlated to the difference in lung volume between FB and DIBH. The difference in ILV between DIBH and FB of 1.8 indicated that the patients obtained more benefit from the DIBH technique. The data suggest that lung volume (ILV and TLV) measured on a CT-simulation scan and the difference between FB and DIBH could be utilized to help select patients for DIBH.