bluuebunny/crossref_metadata_2025_split huggingface dataset:
НЕПРЯМА РЕВАСКУЛЯРИЗАЦІЯ ПРИ ДІАБЕТИЧНІЙ МІКРОАНГІОПАТІЇ – ВІД ЕКСПЕРИМЕНТАЛЬНИХ МОДЕЛЕЙ ДО КЛІНІЧНОГО ЗАСТОСУВАННЯ
Authors: Vastyanov R. S. , Chekhlova O. V. , Chekhlov M. V. 
Published: May 2020

Вступ. Непряму реваскуляризацію при діабетичній мікроангіопатії розглядають як перспективний напрямок лікування та профілактики ускладнень цукрового діабету, проте теоретичне підґрунтя цього підходу недостатньо опрацьовано.
Мета дослідження – оцінити ефективність комбінованої непрямої реваскуляризації в щурів з мікроангіопатією кінцівок на тлі експериментального стрептозотоцинового діабету.
Методи дослідження. Дослідження було виконано за умов хронічного експерименту на 100 щурах лінії Вістар масою 180–250 г. Після введення стрептозотоцину з експерименту виключали тварин з підвищеною резистентністю до панкреатотропної токсичної дії за критерієм відсутності гіперглікемії, після чого впродовж 6-ти тижнів виводили по 2 тварини для виконання морфологічних досліджень. На 7-му тижні з експерименту вивели ще 10 щурів для оцінки ефективності експериментальної моделі. З решти тварин (n=60) сформували три експериментальні групи: 1-ша (контрольна) – щури зі стрептозотоцин­індукованою ангіопатією без лікування (n=10); 2-га – щури зі стрептозотоциніндукованою ангіопатією, яким з лікувальною метою вводили пентоксифілін (100 мг/кг внутрішньочеревно щоденно протягом 10-ти днів) (n=25); 3-тя – щури зі стрептозотоциніндукованою ангіопатією, яким з лікувальною метою сумісно вводили плазму, збагачену тромбоцитами (в праву задню кінцівку, одноразово, обʼємом 0,2 мл, лінійно, ретроградно, з двох точок), та пентоксифілін (100 мг/кг внутрішньочеревно щоденно протягом 10-ти днів) (n=25). Через 4 тижні після початку експериментальної терапії з експерименту виводили по 5 тварин. Загальна його тривалість становила 110 днів.
Результати й обговорення. При експериментальному стрептозотоциновому діабеті на 8-му тижні у тварин розвинулася мікроангіопатія кінцівок. Ізольоване введення пентоксифіліну за реваскуляризуючою активністю поступалося комбінованій терапії. Комбінована терапія із застосуванням пентоксифіліну та плазмофіліну призвела до зменшення периваскулярного набряку і збільшення ефективного васкулярного обʼєму переважно за рахунок зниження інтенсивності запальних проявів.
Висновок. Обговорюється питання щодо доцільності клінічного використання при лікуванні проявів діабетичної мікроангіопатії комбінації пентоксифіліну та плазми, збагаченої тромбоцитами, як засобу непрямої реваскуляризації.
Contabilidade e auditoria interna no setor público brasileiro: percepção dos contadores públicos frente à convergência para as IPSAS/IFAC
Authors: Marques Luciane Ribas , Bezerra Filho João Eudes , Caldas Olavo Venturim 
Published: May 2020

O objetivo do artigo foi investigar e analisar a percepção de uma amostra de contadores públicos brasileiros sobre a adoção das Normas Brasileiras de Contabilidade Aplicada ao Setor Público no Brasil, atualmente em processo de convergência com as normas da Internacional Federation of Accountants (International Public Sector Accounting Standards). A literatura consultada tem se concentrado em pesquisas quantitativas realizadas a partir das informações contábeis publicadas em prestações de contas junto aos Tribunais de Contas e repositórios do Governo Federal, não adentrando em analisar percepções dos profissionais de contabilidade envolvidos no processo. A teoria da contingência foi abarcada como lastro conceitual. O estudo é exploratório e de caráter descritivo, tendo sido coletados dados por meio de questionário eletrônico, utilizando o método de análise fatorial exploratória. A amostra contou com 168 respondentes. Os resultados indicam que há necessidade de mudanças organizacionais, estruturais, sensibilização da alta administração, de competência técnica-profissional e culturais nos segmentos de contabilidade e auditoria interna dos entes públicos brasileiros visando atender à convergência. Os achados contribuem também para o debate e reflexão sobre o processo de amadurecimento e busca de soluções para adoção de uma contabilidade pública que atenda as demandas de informações dos mais diversos grupos de interessados (internos e externos).
Spider (Arachnida: Araneae) fauna of the scrub jungle in the Madras Christian College campus, Chennai, India
Authors: Caleb John T.D. 
Published: May 2020

A total of 108 species of spider species belonging to 84 genera and 25 families were identified from the scrub jungle of the Madras Christian College campus. Pagida salticiformis (O. Pickard-Cambridge, 1883) is recorded for the first time from India. Langona tigrina (Simon, 1885) is rediscovered 135 years since its first description and the unknown male is described and illustrated. A new combination, Langona davidi (Caleb, Mungkung & Mathai, 2015) comb. nov. is proposed for the species previously placed in Phlegra. Three new synonymys have been recognized: Clubiona foliata Keswani & Vankhede, 2014 and Clubiona pashabhaii Patel & Patel, 1973 are junior synonyms of Clubiona filicata O. Pickard-Cambridge, 1874 and Myrmarachne megachelae Kumar & Mohanasundaram, 1998 is a junior synonym of Myrmaplata plataleoides (O. Pickard-Cambridge, 1869). Distribution records of several species have been updated and as many as 31 species are recorded for the first time from Tamil Nadu State. The family Salticidae is the most diverse with 28 species belonging to 22 genera followed by Araneidae with 19 species in 11 genera. Guild structure analysis revealed seven feeding guilds of which, stalkers and orb-web weavers are the dominant feeding guilds followed by ground runners, ambushers, and scattered line weavers, respectively.
CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress
Authors: Lerchenmüller Carolin , Rabolli Charles P , Yeri Ashish Suresh , Kitchen Robert , Salvador Ane M , Liu Laura X , Ziegler Olivia , Danielson Kirsty M , Platt Colin , Shah Ravi , Damilano Federico , Kundu Piyusha , Riechert Eva , Katus Hugo A , Saffitz Jeffrey E , Keshishian Hasmik , Carr Steve , Bezzerides Vassilios J , Das Saumya , Rosenzweig Anthony 
Published: May 2020

Rationale:Cardiac CITED4 is induced by exercise and is sufficient to cause physiological hypertrophy and mitigate adverse ventricular remodeling after ischemic injury. However, the role of endogenous CITED4 in response to physiological or pathological stress is unknown.Objective:To investigate the role of CITED4 in murine models of exercise and pressure overload.Methods and Results:We generated cardiomyocyte-specific CITED4 knockout mice (C4KO) and subjected them to an intensive swim exercise protocol as well as transverse aortic constriction (TAC). Echocardiography, western blotting, qPCR, immunohistochemistry, immunofluorescence, and transcriptional profiling for mRNA and miRNA expression were performed. Cellular crosstalk was investigated in vitro. CITED4 deletion in cardiomyocytes did not affect baseline cardiac size or function in young adult mice. C4KO mice developed modest cardiac dysfunction and dilation in response to exercise. After TAC, C4KOs developed severe heart failure with left ventricular dilation, impaired cardiomyocyte growth accompanied by reduced mammalian target of rapamycin (mTOR) activity and maladaptive cardiac remodeling with increased apoptosis, autophagy, and impaired mitochondrial signaling. Interstitial fibrosis was markedly increased in C4KO hearts after TAC. RNAseq revealed induction of a pro-fibrotic miRNA network. miR30d was decreased in C4KO hearts after TAC and mediated crosstalk between cardiomyocytes and fibroblasts to modulate fibrosis. miR30d inhibition was sufficient to increase cardiac dysfunction and fibrosis after TAC.Conclusions:CITED4 protects against pathological cardiac remodeling by regulating mTOR activity and a network of miRNAs mediating cardiomyocyte to fibroblast crosstalk. Our findings highlight the importance of CITED4 in response to both physiological and pathological stimuli.
Grammatical Issues Integrated with Quranic Exegesis and Their Impact on Meaning: A Critical Study of the Commentary on Sūrat al-Nisāʾ
Authors: Dror Yehudit 
Published: May 2020

Abstract
This study focuses on the grammatical content of six Quranic exegeses dating from the fourth/tenth to the seventh/thirteenth centuries (see section 1.3). The idea of exploring grammatical aspects of Quranic exegeses is not new in modern research, yet a complete analysis based on a large corpus devoted to the collection, classification, and analysis of the grammatical content of Quranic exegeses is still lacking. This study is limited to an examination of commentaries on sūrat al-nisāʾ. In these, two types of grammatical comments can be distinguished. The first are “formal comments”, in which the commentators conduct a morphological and/or syntactical analysis of various components. Such comments usually include an explicit grammatical term, and most of these have been addressed by traditional grammarians. The second type are “functional comments”. These concern issues that are less common in classical grammatical descriptions, such as agreement, coherence, pragmatics, and other related matters. Usually in these types of comments, no syntactical term is mentioned, although such explanations make important grammatical contributions.
A Critical Analysis of Firestone’s Hypothesis Regarding the Qurʾānic Legislation on Holy War
Authors: Tabataba’i Mohammad Ali , Velayati Maryam 
Published: May 2020

Abstract
Reuven Firestone in his works on the concept of holy war in Islam has criticized the traditional resolution for the problem of disparity between the Qurʾānic verses on war and suggested a new interpretation of the relationship between the verses. This paper aims to reevaluate Firestone’s contribution by taking a closer look at his critique of the traditional theory as well as his alternative suggestion. This study shows that what Firestone attributes to the Muslim tradition is a mistaken projection of some modern views onto the early authorities. The ambivalent stance of Firestone towards the historicity of the early Muslim literature results in a loose hypothesis regarding the formation of the Qurʾānic verses on war which neither meets the traditional specifications, nor satisfies the criteria of the skeptic party of Islamicists.
Analysis on Textual Hadith of Waqf Infrastructure in al-Kutub al-Sittah and Its Applications from the Perspective of Maqasid al-Sunnah
Authors: Suliaman Ishak , Yaakob Mohd Ashrof Zaki 
Published: May 2020

Abstract
The implementation of waqf introduced by the Prophet SAW and his companions are the main reference and guidance for Muslim to expand its continuity for particular category of waqf infrastructure. This article aims to examine the definition and concept of waqf infrastructure. The discussion focuses on analysis of textuals Hadith of waqf that derived from al-Kutub al-Sittah and its application in the perspective of Maqasid al-Sunnah. It is found that there are 36 textuals Hadith regarding waqf in al-Kutub al-Sittah whereby 27 textuals Hadith are categorised as waqf infrastructure. In terms of the discussion on waqf infrastructure within the framework of textuals Hadith, there are 3 main categories such as religious infrastructure, public infrastructure and general infrastructure. In addition, there are 6 types of waqf infrastructure under those categories including waqf of land, waqf of garden, waqf of well Bayruhaʾ, waqf of land for mosque and waqf of military weapons. In the light of Maqasid al-Sunnah, it signifies the development of waqf infrastructure must be in line with the principals and its implementation that introduced by the Prophet SAW and his companions RA.
Pragmatic Interpretation and Translational Equivalence of Ironic Discourse in the Holy Qurʾan Based on SAT and EAT Theories: Arberry’s English Translation as a Case Study
Authors: Abuissac Shehda R.S , Sapar Ahmed Arifin Bin , Saged Ali Gobaili 
Published: May 2020

Abstract
This paper discusses and examines intercultural differences between the Arabic use of ironic language in the Quran and its English translation equivalents by Arberry. The data samples of the study are methodologically classified and interpreted in accordance with Haverkate’s “Speech Acts Theory of Irony” (SATI), the “Echoic Account Theory” by Sperber and Wilson, and Nida’s “Theory of Equivalence”. Throughout the application of pragmatic and translation theories, qualitative analysis is used. Analysis and interpretation led to the conclusion that Arabic traditional culture, semantically complex language concepts like polysemy, idiomatic multi-word expressions and, above all, emotive images play fundamental roles that are impeding the translations of ironic speech acts from the Qurʾan into adequate English equivalents. The study also shows how verbal irony intersects with other figures and tropes. Its interface produces a vast range of various functions and dissociative thoughts, while being open to many interpretations. Lastly, the study shows how translational techniques can mitigate, minimize and overcome the problems of corresponding equivalence. The study suggests future research into the role that discourse parameters play for the translational transfer of Qurʾanic ironic speech acts and for all other figurative language types that are interrelated with verbal irony.
Orphan(ed) Scroll: the Case of Contextualizing a Late Qing Object in a Slovenian Museum
Authors: Motoh Helena 
Published: May 2020

Abstract
This paper focuses on the methodological problem of contextualizing singular, ‘orphaned’ museum objects when provenance is unknown. In the late 1940s in Slovenia/Yugoslavia, the haste and non-transparent process of confiscation and subsequent reappropriation took many objects from collections that they were part of and placed them in new contexts, often leaving them unexhibited due to their problematic origin. The paper takes up one such singular object, a rare late nineteenth-century Jesuit missionary scroll from Shanghai that was left without information about its provenance or former owner. It first presents the steps taken in the identification of the object, its content, and background. Then the struggle of contextualizing the object is presented, along with the limitations of this process. Finally, a reflection on the status of ‘orphaned’ objects follows, with an attempt to assess the potential of such examples against the contextualizing approaches of museum representations.
Use of Multiensemble Track Clustering to Inform Medium-Range Tropical Cyclone Forecasts
Authors: Kowaleski Alex M. , Evans Jenni L. 
Published: May 2020

AbstractTropical cyclone ensemble track forecasts from 153 initialization times during 2017–18 are clustered using regression mixture models. Clustering is performed on a four-ensemble dataset [ECMWF + GEFS + UKMET + CMC (EGUC)], and a three-ensemble dataset that excludes the CMC (EGU). For both datasets, five-cluster partitions are selected to analyze, and the relationship between cluster properties (size, ensemble composition) and 96–144-h cluster-mean error is evaluated. For both datasets, small clusters produce very large errors, with the least populous cluster producing the largest error in more than 50% of forecasts. The mean of the most populous EGUC cluster outperforms the most accurate (EGU) ensemble mean in only 43% of forecasts; however, when the most populous EGUC cluster from each forecast contains ≥30% of the ensemble population, its average cluster-mean error is significantly reduced compared to when the most populous cluster is smaller. Forecasts with a highly populous EGUC cluster also appear to have smaller EGUC-, EGU-, and ECMWF-mean errors. Cluster-mean errors also vary substantially by the ensembles composing the cluster. The most accurate clusters are EGUC clusters that contain threshold memberships of ECMWF, GEFS, and UKMET, but not CMC. The elevated accuracy of EGUC CMC-excluding clusters indicates the potential utility of including the CMC in clustering, despite its large ensemble-mean errors. Pruning ensembles by removing members that belong to small clusters reduces 96–144-h forecast errors for both EGUC and EGU clustering. For five-cluster partitions, a pruning threshold of 10% affects 49% and 35% of EGUC and EGU ensembles, respectively, improving 69%–74% of the forecasts affected by pruning.
Comparison of outcomes of the use of Del Nido and St. Thomas cardioplegia in adult and paediatric cardiac surgery: a systematic review and meta-analysis
Authors: Ler Ashlynn , Sazzad Faizus , Ong Geok Seen , Kofidis Theo 
Published: May 2020

Background: In recent years, the use of del Nido cardioplegia, initially intended for paediatric cardiac surgery, has been extended to adult cardiac surgery in many institutions. Our aim was thus to compare the outcomes of the use of del Nido cardioplegia with that of conventional cardioplegia and discuss its role in both adult and paediatric cardiac surgery. Method: A systematic literature search was conducted in August 2019 on Medline (via PubMed), Embase and Cochrane electronic databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Any retrospective studies and randomised controlled trials that reported findings comparing the outcomes of the use of del Nido cardioplegia with that of St. Thomas cardioplegia were included. Results: We observed shorter aortic cross-clamp time (mean difference: −15.18, confidence interval: −27.21 to −3.15, p = 0.01) and cardiopulmonary bypass time (mean difference: −13.52, confidence interval: −20.64 to −6.39, p = 0.0002) associated with the use of del Nido cardioplegia in adult cardiac surgery as compared to St. Thomas cardioplegia. Defibrillation rates were significantly lower in patients who had been given del Nido cardioplegia, in both adult (relative risk: 0.28, confidence interval: 0.12 to 0.64, p = 0.003) and paediatric patients (relative risk: 0.25, confidence interval: 0.08 to 0.79, p = 0.02). Conclusion: Del Nido cardioplegia may be a viable alternative to the use of St. Thomas cardioplegia in both adult and paediatric patients, providing similar postoperative outcomes while also affording the additional advantage of shorter aortic cross-clamp time and cardiopulmonary bypass time (in adult cardiac surgery) and decreased rates of defibrillation (in both adult and paediatric cardiac surgery).
Serum IL-23, E-selectin and sICAM levels in non-small cell lung cancer patients before and after radiotherapy
Authors: Kiziltunc Ozmen Hilal , Simsek Melih 
Published: May 2020

Objective The functions of E-selectin, interleukin (IL)-23, and soluble intercellular adhesion molecule (sICAM) in patients with non-small cell lung cancer (NSCLC) patients before and after radiotherapy (RT) are poorly understood. The purpose of our study was to investigate serum IL-23, E-selectin and sICAM levels in NSCLC patients before and after RT. Methods Forty-four patients with pathologically confirmed NSCLC and 30 healthy individuals were included in the study. All patients received 66.6 Gy of concurrent RT. Results Significant differences were observed between serum IL-23, E-selectin and sICAM levels in controls and NSCLC patients both before and after radiotherapy. Inverse correlations were detected between serum IL-23 and E-selectin levels in NSCLC patients before and after RT. Positive correlations were detected between serum sICAM levels of NSCLC patients before and after RT and RT dose. No associations were observed between RT dose and IL-23 or E-selectin levels in patients before and after RT. Conclusion Serum IL-23, E-selectin and sICAM levels were elevated in NSCLC patients. While our results demonstrate the prognostic value of these parameters, further molecular studies of NSCLC patients are warranted.
Meaningful Modeling of Section Bus Running Times by Time Varying Mixture Distributions of Fixed Components
Authors: Büchel Beda , Corman Francesco 
Published: May 2020

Understanding the variability of bus travel time is a key issue in the optimization of schedules, transit reliability, route choice analysis, and transit simulation. The statistical modeling of bus travel time data is of increasing importance given the increasing availability of data. In this paper, we introduce a novel approach to modeling the day-to-day variability of urban bus running times on a section level. First, the explanatory power of conventionally used distributions is examined, based on likelihood and effect size. We show that a mixture model is a powerful tool to increase fitting performance, but the applied components need to be justified. To overcome this issue, we propose a novel model consisting of two individual characteristic distributions representing either off-peak or peak hour dynamics. The observed running time distribution at every hour of the day can be described as a combination (mixture) of the two dynamics. The proposed time varying model uses a small set of parameters, which are physically interpretable and capable of accurately describing running time distributions. With our modeling approach, we reduce the complexity of mixture models and increase the explanatory power and fit compared with conventional models.
Poly (I:C) Exposure in Early Life Alters Methylation of DNA and Acetylation of Histone at Synaptic Plasticity Gene Promoter in Developing Rat Brain Leading to Memory Impairment
Authors: Baghel Meghraj Singh , Singh Brijendra , Patro Nisha , Khanna Vinay Kumar , Patro Ishan Kumar , Thakur Mahendra Kumar 
Published: May 2020

Background: Exposure to adverse environmental conditions such as toxic chemicals, viral infections, and even stress during pregnancy or early life may disrupt the development of normal brain and its functioning leading to incidence of neurodevelopmental disorders at later stages of life. Recently, we reported that poly (I:C) exposure altered synaptic plasticity protein level and impaired memory through activation of microglia cells. Purpose: As epigenetic modifications are involved in memory formation, we have studied methylation of DNA and acetylation of histone at promoters of synaptic plasticity genes in the brain of rats exposed to poly (I:C) during early life. Methods: One dose of poly (I:C) (5 mg/kg bw) was intraperitoneally injected to rat pups on postnatal seventh day. A set of pups exposed to vehicle was included as control. In order to assess methylation of DNA and acetylation of histone at synaptic plasticity gene promoter, we performed qPCR after methylated DNA immunoprecipitation and chromatin immunoprecipitation. Results: Poly (I:C) exposure reduced the level of 5-methylcytosine (5mC) at synaptic plasticity gene ( bdnf, arc, and egr1) promoters in the frontal cortex (FC) and hippocampus of 3-week rats, although increased it later in both regions of 12-week rats as compared to respective controls. On contrary, poly (I:C) exposure enhanced acetylation of histone H3K9 (H3K9Ac) at promoters of these genes in both regions of 3-week rats but decreased in 12-week rats. Conclusion: Poly (I:C) exposure altered 5mC and H3K9Ac at synaptic plasticity gene promoters resulting in memory impairment of rats at later life.