bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin attenuates vascular calcification by activating mitochondrial fusion and mitophagy via an AMPK/OPA1 signaling pathway
Authors: chen chenweiren , yang jia qi , liu fang , shen xue qin , sha yuan 
Published: November 2019

Abstract
Background: Mitochondrial fusion/mitophagy play a role in cardiovascular calcification. Melatonin has been shown to protect against cardiovascular disease. This study sought to explore whether melatonin attenuates vascular calcification by regulating mitochondrial fusion/mitophagy via an AMP activated protein kinase/ Optic atrophy 1 (AMPK/OPA1) signaling pathway.Methods: The effects of melatonin on vascular calcification were investigated in vascular smooth muscle cells (VSMCs). Calcium deposits were visualised by Alizarin red staining. Calcium content and alkaline phosphatase (ALP) activity were used to evaluate osteogenic differentiation. Western blots were used to measure expression of runt-related transcription factor 2 (Runx2), mitofusin 2 (Mfn2), mito-light chain 3 II (LC3II) and cleaved caspase3. Results: Melatonin markedly reduced calcium deposition and ALP activity. Runx2 and cleaved caspase3 were found to be down-regulated and Mfn2 or mito-LC3II was found to be enhanced in response to melatonin, together with a decrease in mitochondrial superoxide levels. Melatonin also maintained mitochondrial function and promoted mitochondrial fusion/mitophagy via OPA1 pathway. But OPA1 deletion abolished the protective effects of melatonin on VSMC calcification. Melatonin treatment significantly increased the p-AMPK and OPA1 protein expression. Treatment with compound C ablated the benefit observed with melatonin treatment. Conclusions: Melatonin protects VSMC against calcification by promoting mitochondrial fusion/mitophagy via AMPK/OPA1 pathway.
Anais XLVII Semana Odontológica UNIFAL-MG
Authors: Almeida Daniel Augusto de Faria , Paleari André Gustavo , Haddad Marcela Filié , Trindade Miler Lucas Santos da 
Published: November 2019

EditorialCaro(a) Leitor(a),O curso de Odontologia da UNIFAL-MG é reconhecido por sua tradição dentro da Universidade e conta com ensino de excelência, com embasamento sólido e integrados na ciência odontológica em constante atualização.Para tal situação, eventos de forte impacto, carregados com o que há de mais recente no campo do ensino e pesquisa são de grande valia para a formação e/ou atualização profissional. E, é neste sentido que a Semana Científica Odontológica da UNIFAL-MG faz-se valer, completando sua 47ª edição em 2019, atendendo a cada edição um grande público entre acadêmicos a congressistas profissionais.Com o objetivo de divulgar os avanços científicos e tecnológicos para prevenção, diagnóstico e tratamento indicados atualmente na Odontologia, esta edição do evento contou com palestrantes que promoveram a discussão de temas relevantes e atuais para os acadêmicos e profissionais da área.Prof.Dr.Daniel Augusto de Faria AlmeidaCoordenador - XLVII Semana Odontológica UNIFAL-MG
Molecular Mechanisms Involved in the Antitumor Activity of Isolated Lectins from Marine Organisms: A Systematic Review
Authors: Ferreira Hugo Jefferson , de Almeida Evandro Moreira , da Silva Wildson Max Barbosa , Teixeira Edson Holanda , do Nascimento Neto Luiz Gonzaga 
Published: November 2019

Introduction:Tumor cells may present several molecular alterations that favor their malignancy, among which there is the expression of tumor-related antigens, such as truncated T-glycans, Thomsen-nouvelle, sialyl-Lewis X and sialyl Tn, which may help in the diagnosis and treatment using specific target molecules. Lectins are ubiquitous proteins capable of interacting with specific carbohydrates. Lectins isolated from marine organisms have important characteristics such as low immunogenicity and can bind to complex glycans compared to plant lectins.Objective:This work evaluated, through a systematic review, the molecular mechanisms of antitumor activity of lectins isolated from marine organisms. Methodology: The Pubmed, Lilacs, Science Direct, Wiley and Scopus databases were reviewed using the descriptors: marine lectin and cancer. Articles in English, published between January 2008 and December 2018, which proposed the molecular mechanisms of anticancer activity of lectins from marine organisms were eligible for the study.Results:17 articles were eligible. The lectins showed promising performance against cancer cells, presenting specific cytotoxicity for some types of malignant cells. The articles presented several lectins specific to different carbohydrates, modulating: pro and anti-apoptotic proteins, transcription factor E2F-1, via mitogen-activated protein kinase. In addition, exogenous lectin expression in cancer cells has been shown to be a promising way to treat cancer.Conclusion:This review showed the various studies that described the molecular mechanisms caused by marine lectins with antineoplastic potential. This knowledge is relevant for the development and use of the next generations of lectins isolated from marine organisms, supporting their potential in cancer treatment.
Nutritional Composition and Qualitative Phytochemical Analysis of Chia Seeds (Salvia hispanica L.) Grown in East Africa
Authors: Mihafu Fabian D. , Kiage Beatrice N. , Okoth Judith K. , Nyerere Andrew K. 
Published: November 2019

Background:
Chia seed (Salvia hispanica L.) is becoming one of the most popular plantbased
foods that contain the greatest amount of nutrients particularly omega-3 fatty acid, α-linolenic
acid. It is therefore considered a functional food with pronounced health benefits.

Objective:
The purpose of this study was to determine the proximate composition, minerals, fatty acid
profiles and phytochemical contents of chia seeds grown in East Africa (Kenya and Uganda).

Methods:
Official methods of analysis, 2005 were adopted, minerals determined by Atomic absorption
spectrophotometer, phytochemicals were determined by standard methods and fatty acid profiles
were analyzed by Gas chromatography.

Results:
Proximate composition indicated high contents of protein, fat and fiber. The fatty acid profiles
revealed great amounts of α-linolenic acid (45.29-56.99%) followed by linoleic acid (15.9-
20.28%) and oleic acid (6.88-11.58%). However, the difference in the content of α-linolenic acid between
samples was not significant (p = 0.7391). Mineral determination (mg/100g) showed high contents
of potassium (492.96-862.98), phosphorous (486.45-569.45), calcium (297.47-429.09) and
magnesium (192.22-202.97) while considerable amount was observed for iron, zinc, manganese, and
copper. There was a significant difference (p = 0.0001) in mineral content between black chia Molo
and white chia Bukembo with the exception of phosphorus.

Conclusion:
Both black and white chia seeds grown in East Africa, observed to have high amounts
of α-linolenic acid, proteins, fats, fiber, and minerals. These findings support the evidence that chia is
rich in nutrients that are beneficial to human health. Therefore, we suggest its incorporation in diets
as a healthy food ingredient.
Prevalence and Predictors of Self-Medication Practices in India: A Systematic Literature Review and Meta-Analysis
Authors: Rashid Muhammed , Chhabra Manik , Kashyap Ananth , Undela Krishna , Gudi Sai K. 
Published: November 2019

Background:
Self-Medication (SM) is a practice of using medications to treat selfdiagnosed
symptoms without a legitimate prescription by a health care professional. Alongside
posing a burden on a patient, SM practices are associated with certain unfavourable health conditions
such as drug-resistance, adverse effects, drug-interactions, including death.

Objective:
To systematically review and quantify the prevalence of SM practices and its associated
factors in India.

Methodology:
A comprehensive systematic search was performed using scientific databases such as
PubMed and Cochrane library for the peer-reviewed research articles that were conducted in India
without any language and date restrictions. Studies which were cross-sectional by design and assessing
the prevalence and predictors of SM practices in India were considered for the review, and
all the relevant articles were screened for their eligibility.

Results:
Of 248 articles, a total of 17 articles comprising of 10,248 participants were included in the
meta-analysis. Overall, the mean prevalence of SM practices in India was observed to be 53.57%.
Familiarity with the medication appears to be a major reason to practice SM (PR: 30.45; 95%
Confidence Interval [CI]: 17.08-43.82; 6 studies), and the practice was noticed more among
individuals from a middle-lower class family with a prevalence rate of 26.31 (95%CI: 2.02-50.60;
P<0.0001). Minor ailments were the primary reason for practicing SM (PR: 42.46; 95%CI: 21.87-
63.06), among which headache was the most commonly reported (PR: 41.53; 95%CI: 18.05-65.02).

Conclusion:
Self-medication practices are quite frequent in India. While NSAIDs and anti-allergens
are the most frequently utilized self-medicated drugs used for headache and cold and cough.
The effects of ozone therapy on extremity ischemia-reperfusion injury in a rabbit model
Authors: KAYMAZ Burak , COBAN Ganime , GOKSEL Ferdi , TOMAN Huseyin , GOLGE Umut Hatay , KOMURCU Erkam 
Published: November 2019

Introduction: Ischemia is reversible or
irreversible cell/tissue damage that is secondary to insufficient blood flow to
tissues or organs. Ischemia causes many metabolic and structural changes at the
cellular level. Ozone therapy is often used as an antioxidant remedy. This
study aimed to investigate the effects of ozone therapy on extremity
ischemia-reperfusion (IR) injury.

Methods: Twenty-four New Zealand
White (NZW) rabbits were randomly allocated into three groups. Each group
consisted of eight rabbits. Group I was the control group, Group II was the
ischemia group, and Group III, the ozone group.
Femoral arteries of the right legs were dissected, and femoral arterial
occlusion was performed in Group II and III.
Hematological and histopathological evaluation was performed in all
groups.

Results: The levels of total
antioxidant status (TAS) after the surgical procedure was higher in the ozone
group compared to the ischemia group (p=0.036). In addition, the levels of
malondialdehyde (MDA) after the surgical procedure were lower in the ozone
group compared to the ischemia group but not statistically significant
(p=0.093). The control and ozone groups were histopathologically similar.

Conclusions: Ozone therapy may be used
as an alternative treatment modality with its anti-inflammatory and antioxidant
effects for the treatment of extremity IR injury.
ANALISA PRODUKTIVITAS DENGAN MENGGUNAKAN MODEL PENGUKURAN THE AMERICAN PRODUCTIVITY CENTER (APC) PADA PRODUK ALUMUNIUM SHEET DAN ALUMUNIUM FOIL
Authors: Beatrix Meike , Dewi Anis Anisah 
Published: November 2019

Untuk meningkatkan volume penjualan dan keuntungan, maka perusahaan perlu memantau kinerja perusahaan secara keseluruhan, bukan hanya berdasarkan tingkat profitabilitas namun juga berdasarkan tingkat produktivitas. Produktivitas merupakan perbandingan antara output yang dihasilkan dan input yang digunakan. Penelitian ini bertujuan untuk mengetahui berapa besar tingkat produktivitas yang telah dicapai oleh perusahaan dengan menentukan indeks produktivitas, indeks profitabilitas dan indeks perbaikan harga dengan menggunakan model pengukuran The American Productivity Center (APC). Indeks produktivitas total yang diperoleh pada periode 2017 yaitu 114,252% dengan indeks produktivitas input tenaga kerja, material, energi dan modal masing-masing pada periode 2017 yaitu 116,166%, 113,168%, 120,808%, 115,523%. Indeks profitabilitas total yang diperoleh pada periode 2017 yaitu 110,766% dengan indeks profitabilitas input tenaga kerja, material, energi dan modal masing-masing pada periode 2017 yaitu 128,903%, 103,246%, 129,615%, 125,563%. Indeks perbaikan harga dari tahun 2016 ke tahun 2017 diperoleh indeks perbaikan harga tertinggi pada input tenaga kerja yaitu 1,110% dan indeks perbaikan harga terendah pada input material yaitu 0,912%, indeks perbaikan harga energi dan modal masing-masing yaitu 1,073% dan 1,087%. Besar kecilnya indeks perbaikan harga dipengaruhi oleh biaya input yang digunakan untuk menghasilkan sejumlah output.
Hacia una concepción pragmatista de la educación estética y de la crítica de arte en la perspectiva de John Dewey
Authors: Rueda Leopoldo 
Published: November 2019

En este trabajo, nos proponemos indagar en qué sentido(s) puede serentendida una educación estética en la teoría deweyana, lo que nos llevará a revisar las concepciones naturalistas de educación, arte y crítica. Finalizaremos señalando los diversos modos en que puede comprenderse que el arte educa y cuáles son los desafíos a afrontar ante una propuesta de estas características.Palabras clave: pragmatismo, educación estética, arte.
Silang Sengkarut Pembangunan Berkelanjutan Perkotaan Dalam Pusaran Kapital (Studi Kasus: Megaproyek Reklamasi CPI Makassar)
Authors: Anwar Andi Faisal , Aswandi Khairil 
Published: November 2019

Kebutuhan akan lahan di perkotaan kian hari kian meningkat, yang disebabkan peningkatan jumlah penduduk dan industrialisasi. Untuk memenuhi akan kebutuhan itu, maka salah satu cara yang bisa digunakan yaitu, dengan melakukan reklamasi kawasan pesisir. Termasuk proyek reklamasi yang berjalan di Kota Makassar yaitu, pembangunan megaproyek CPI (Centre Point of Indonesia) di Makassar. Akan tetapi, reklamasi itu nampaknya menimbulkan dampak sosial ekonomi dan kerusakan lingkungan yang cukup destruktif. Beranjak dari masalah inilah, peneliti ingin melihat apakah reklamasi tepat dijalankan dalam perspektif green economy. Penelitian ini berlokasi di Kelurahan Panambunga, Kecamatan Mariso, Kota Makassar. Metode analisis data yang digunakan dalam penelitian ini, yaitu metode kualitatif, dengan pendekatan studi kasus. Hasil yang didapatkan dalam penelitian ini antara lain, pembangunan perkotaan dengan melalui reklamasi itu tidak tepat dilakukan, karena sangat berdampak secara sosial dan lingkungan, termasuk penurunan pendapatan. Semuanya, menyimpang dari persyaratan pembangunan berkelanjutan. Pembangunan proyek reklamasi ini seringkali menimbulkan konflik dalam keluarga, oleh karena himpitan ekonomi, yang kian parah, yang disebabkan oleh menurunnya tingkat pendapatan, disaat yang sama terjadi peningkatan jumlah kebutuhan yang kian hari kian meningkat ditengah kompleksitas perkotaan. Sedangkan dampak ekonomi yang ditimbulkan berdasarkan hasil penelitian ini yaitu, terjadi penurunan drastis pendapatan nelayan sebelum dan selama pembangunan megaproyek reklamasi CPI Makassar tersebut. Dimana, pasca reklamasi terjadi penurunan pendapatan secara drastis, yang mengakibatkan menurun kualitas penghidupan masyarakat pesisir.
The Development of the Physiological Adjustment of Physical Loads and Its Impact on the Circulatory System and the Skills of Football Players
Authors: Idris Khodja Reda Mohamed , Hicham Betar , Mokrani Djamel 
Published: November 2019

Summary
This research was focused on the important question, what is the effect of the development of physiological adjustment of the physical load on the respiratory system and the performance of the skills of football players. In addition we tried to comfirm the relationship between the physical qualities and the performance of the skills. We have applied the experimental approach which best suits to this type of question. Proposing a program based on the physiological adjustment of the respiratory system, we applied the approach to a sample of twenty players (table 3), which were a deliberate sample divided into experimental and control, during the general physical preparation. The results confirmed that there are statistically significant differences between the pre-test and post-test of the experimental sample in both the respiratory system tests and the functional performance tests, in addition to statistical differences between the control and experimental groupe in the post-test.
Row spacing and weed management methods influences growth and yield of soybean (Glycine max (L.) Merr.)
Authors: Daramola Olumide Samuel , Adeyemi Olusegun Raphael , Adigun Joseph Aremu , Adejuyigbe Christopher Olu 
Published: November 2019

Abstract
Weed infestation is among the primary reasons for low yields of soybean in Nigeria and other parts of Sub Saharan Africa (SSA). Field trials were therefore carried out in 2016 and 2017 cropping seasons to evaluate the effect of row spacing and weed management methods on growth and yield of soybean. The use of 50 cm row spacing resulted in significant (P < 0.05) reduction in weed cover score, weed density and weed dry matter with subsequent increase in soybean growth and grain yield compared to 75 and 100 cm row spacings in both years. In addition, early weed control with probaben at 2.0 kg a.i (active ingredient) ha1 followed by (fb) supplementary hoe weeding (shw) at 6 weeks after sowing (WAS) suppressed weeds and increased soybean growth, which carried through to final dry matter and yield. Pre-emergence application of Probaben fb shw at 6 WAS gave the best weed control and resulted in significantly (P < 0.05) higher soybean grain yield compared to two and three hoe weedings or sole application of probaben under 50 and 75 cm inter-row spacing. However, three hoe weedings gave the best weed control and grain yield under 100 cm inter-row spacing. These results suggest that narrow row spacing of 50 cm and weed control by pre-emergence application of probaben fb shw will improve the productivity of soybean. Wide row spacing, however, required longer weed-free period and consequently multiple hoe weeding for optimum soybean yield.
Two - Echelon Vehicle Routing Problem with Recharge Stations
Authors: Agárdi Anita , Kovács László , Bányai Tamás 
Published: November 2019

Abstract
The efficient operation of logistic processes requires a wide range of design tasks to ensure efficient, flexible and reliable operation of connected production and service processes. Autonomous electric vehicles support the flexible in-plant supply of cyber-physical manufacturing systems. Within the frame of this article, the extension of the Two-Echelon Vehicle Routing Problem with recharge stations is analyzed. The objective function of the optimization problem is the minimization of operation costs. The extension of 2E-VRP means that the second level vehicles (electric vehicles, must be recharged) come from one recharge station, then pick up the products from the satellite, visit the customers and return to the recharge station from where it started. We solved the route planning problem with the application of construction heuristics and improvement heuristics. The test results indicate that the combination of this approach provides a superior efficiency.
Rancang Bangun Aplikasi Game 3D “KARMA” sebagai Media Mengenal Hukuman dari Perbuatan Buruk Berbasis Android
Authors: Sri Diah Sukayanti Ida Ayu , Adi Purnawan I Ketut , Agung Cahyawan Wiranatha A. A. Ketut 
Published: November 2019

Dosa diartikan sebagai karma atau perbuatan buruk manusia. Dosa merupakan perbuatan yang dilarang oleh Tuhan yang mengakibatkan manusia masuk Neraka. Game 3D “KARMA” dikembangkan bertujuan untuk penyampaian pengetahuan mengenai hukuman dari perbuatan buruk atau dosa. Game 3D “KARMA” dapat membuat pengguna lebih memahami tentang pentingnya berbuat baik dan menghindarkan diri dari perbuatan buruk. Game yang dikembangkan ber-genre side-scrolling running, menampilkan objek 3 Dimensi (3D) dan jenis rintangan berbeda pada setiap gameplay, yang mengangkat cerita dari hukuman yang diterima oleh manusia setelah meninggal, yang melakukan perbuatan buruk semasa hidupnya. Game 3D “KARMA” menggunakan sensor Accelerometer sebagai pengendali karakter menghindari rintangan ke kanan dan ke kiri dengan memiringkan smartphone, yang diimplimentasikan dalam bahasa pemograman C#. Game 3D “KARMA” yang dihasilkan memiliki 4 level gameplay dengan jenis perbuatan buruk dan hukuman yang berbeda dengan gameplay Level 1 Alam Maya, Level 2 Bukit Gersang, Level 3 Sungai Licin dan Level 4 Jembatan Gantung yang menggunakan objek 3D.
Kata Kunci: Perbuatan Buruk, Game Edukasi, Accelerometer, 3D, Game Petualangan.
Aplikasi Optimalisasi Pengiriman Barang Menggunakan Metode Tabu Search Berbasis Web
Authors: Irvan Arya Purwadana Putu , Putra Githa Dwi , Purnami Singgih Putri Desy 
Published: November 2019

Tujuan pengiriman barang adalah menyampaikan barang dalam kondisi yang baik dan cepat. Pengiriman barang berjalan efisien apabila memperhatikan faktor pengiriman barang yaitu, wilayah dan muatan. Masalah pengiriman barang yang biasanya terjadi yaitu pengiriman dilakukan secara acak dan barang yang dikirim tidak sesuai kapasitas kendaraan. Masalah tersebut menjadi latar belakang pembuatan aplikasi optimalisasi pengiriman barang. Aplikasi optimalisasi pengiriman barang bertujuan untuk mencari rute pengiriman barang yang optimal tidak hanya berdasarkan jarak tapi juga muatan. Metode Tabu Search digunakan pada aplikasi optimalisasi pengiriman barang untuk mencari rute pengiriman terbaik dari beberapa alternatif rute yang terbentuk. Aplikasi optimalisasi pengiriman barang memanfaatkan Google Maps untuk mendapatkan jarak pengiriman dan visualisasi rute pengiriman. Hasil dari aplikasi optimalisasi pengiriman barang yaitu menentukan barang yang dikirim oleh kendaraan, rute pengiriman barang yang optimal dan visualisasi rute dalam bentuk maps.
Kata Kunci: Pengiriman Barang, CVRP, Metode Tabu Search.
Analisis faktor-faktor yang mempengaruhi Kinerja pegawai pada dinas kesehatan Kabupaten kutai timur
Authors: Rizki Meita Sondang 
Published: November 2019

The study tries to identify to what extent incentive, competence, motivation, discipline, work environment, social security, nutrition and health of staff Health Department, it will also identify which factors give the most impact toward staff performance. This research excepted to benefit to all side, especially for institution head to dig elements that increasing performance of staff Health Department in Sangatta. Analysis model used to prove hypothesis is model analysis multiple linier regression that be analysed with using statistics computer program package, that is SPSS v. 14.0 for Windows. Responden that becoming objective this research are counted 75 of staff Health Department. Result of statistics analysis show that coefficient of the free variables regression, that is involvement factor in incentive (X1) = 0,164, competence (X2) = 0,178, motivation (X3) = 0,148, discipline (X4) = 0,048, work environment (X5) = 0,287, social security (X6) = 0,176, nutrition and health (X7) = 0,130, and constanta equal to 0,366. Equation of multiple linier regression is : Y = 0,366 + 0,164 X1 + 0,178 X2 + 0,148 X3 + 0,048 X4 + 0,287 X5 + 0,176 X6 + 0,130 X7 Conclusion that receive that level of influence explained by incentive, competence, motivation, discipline, work environment, social security, nutrition and health as independent variable impact toward performance of staff Health Department equal to correlation coefficient (R), that is 0,869 and level of depended performance to seventh of free variables above is equal to determination coefficient value (R2) that is 0,755 or 75,5 %. Result of analysis F – test indicate that all free variables by together have significant influence toward performance of staff Health Department. By parsial, variable incentive, competence, motivation, work environment, social security, nutrition and health have significant influence to performance of staff Health Department. Only one variable is discipline have no significant. Variabel independent have dominant influence to performance of staff Health Department is work environment (X5).