bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic potentials with phytochemical screening of flowers of Brassica nigra
Authors: Uddin Mohammad Sarowar , Millat Md. Shalahuddin , Islam Mohammad Safiqul , Hussain Md. Saddam , Uddin Md. Giash , Siddiqui Shafayet Ahmed , Ferdous Mahmuda 
Published: October 2020

Abstract
Background
Brassica nigra is a plant of Brassicaceae family, which possesses numerous medicinal values. Our present study is intended to assess the potential in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic properties of MCE of B. nigra flowers. MCE was fractioned for separating the compound on the basis of polarity by using chloroform, n-hexane and ethyl acetate solvent. Thrombolytic and anthelminthic activities were explained by collecting human erythrocytes and earthworms as test models, respectively. Anxiolytic activity was evaluated by elevated plus maze and hole board models while cytotoxic test was conducted through brine shrimp lethality bioassay.

Results
MCE revealed the presence of alkaloids, flavonoids, tannin, diterpenes, glycosides, carbohydrates, phenols, fixed oils and fat. In case of thrombolytic test, the MCE, CSF, ASF and n-HSF had produced maximum clot lysis activity at 5 and 10 mg/ml dose conditions. Two different concentrations (10 and 20 mg/ml) of MCE and its fractions showed significant (p < 0.05) anthelminthic activities in a dose-dependent manner. Significant anxiolytic activity was observed for all fractions which was comparable to the standard drug diazepam (p < 0.05). Again, the cytotoxic screening also presented good potentials for all fractions.

Conclusion
From the findings of present study, we can conclude that MCE of B. nigra flowers and its fraction possess significant anxiolytic, anthelmintic, anticancer and thrombolytic properties which may be a good candidate for treating these diseases through the determination of bio-active lead compounds.
Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model
Authors: Aziz Md. Arfin Ibn , Barua Niloy , Tareq Abu Montakim , Alam Najmul , Prova Ranak Jahan , Mamun Miskatun Nur , Sayeed Mohammed Aktar , Chowdhury Md. Ashraf Uddin , Emran Talha Bin 
Published: October 2020

Abstract
Background
Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST).

Results
Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%.

Conclusion
Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required.
Effect of head and neck radiotherapy on the Eustachian tube functions
Authors: Hamd Ahmed Abdullah , Behiry Essam Abd El-Wanes , Atallah Adel Tharwat , Elaini Sherif Maher , Alshafai Ahmed Hamdy 
Published: October 2020

Abstract
Background
Nowadays, radiotherapy is widely used in management of many types of tumors including head and neck tumors; in this study, we concerned with its reverse effects on the Eustachian tube functions and if this effect is temporary or permanent.

Results
The whole (30) patients have tympanogram at both ears before starting radiotherapy; all patients (100%) were normal. In the immediate post radiotherapy tympanogram at the contralateral side, 6.7% of patients had effusion, and 20% had Eustachian tube dysfunction, while at the ipsilateral side, 20% of patients had effusion, and 33.3% had ET dysfunction. In the follow-up tympanogram 12 weeks post radiotherapy, we found that 6.7% of patients had effusion, and (10%) had Eustachian tube dysfunction at the contralateral side, while 6.7% of patients had effusion, and only 20% had Eustachian tube dysfunction at the ipsilateral side.

Conclusion
From this study, we concluded that patients with head and neck tumors treated by radiotherapy (apart from the nasopharynx) have a high incidence of affection of Eustachian tube function namely middle ear effusion and Eustachian tube dysfunction. The possibility for development of middle ear effusion and Eustachian tube dysfunction increases with increased tumor stage. Eustachian tube functions immediately post radiotherapy and after 12 weeks of the end of radiotherapy was affected by different effects according to the tumor site. The Eustachian tube functions significantly improved within 12 weeks after the last dose of radiotherapy, and we recommend audiological follow-up for patients with head and neck tumors treated with radiotherapy.
A Forensic Disassembly of the BIS Monitor
Authors: Connor Christopher W. 
Published: October 2020

BACKGROUND:
The bispectral index (BIS) monitor has been available for clinical use for >20 years and has had an immense impact on academic activity in Anesthesiology, with >3000 articles referencing the bispectral index. Despite attempts to infer its algorithms by external observation, its operation has nevertheless remained undescribed, in contrast to the algorithms of other less commercially successful monitors of electroencephalogram (EEG) activity under anesthesia. With the expiration of certain key patents, the time is therefore ripe to examine the operation of the monitor on its own terms through careful dismantling, followed by extraction and examination of its internal software.

METHODS:
An A-2000 BIS Monitor (gunmetal blue case, amber monochrome display) was purchased on the secondary market. After identifying the major data processing and storage components, a set of free or inexpensive tools was used to retrieve and disassemble the monitor’s onboard software. The software executes primarily on an ARMv7 microprocessor (Sharp/NXP LH77790B) and a digital signal processor (Texas Instruments TMS320C32). The device software can be retrieved directly from the monitor’s hardware by using debugging interfaces that have remained in place from its original development.

RESULTS:
Critical numerical parameters such as the spectral edge frequency (SEF), total power, and BIS values were retraced from external delivery at the device’s serial port back to the point of their calculation in the extracted software. In doing so, the locations of the critical algorithms were determined. To demonstrate the validity of the technique, the algorithms for SEF and total power were disassembled, comprehensively annotated and compared to their theoretically ideal behaviors. A bug was identified in the device’s implementation of the SEF algorithm, which can be provoked by a perfectly isoelectric EEG.

CONCLUSIONS:
This article demonstrates that the electronic design of the A-2000 BIS Monitor does not pose any insuperable obstacles to retrieving its device software in hexadecimal machine code form directly from the motherboard. This software can be reverse engineered through disassembly and decompilation to reveal the methods by which the BIS monitor implements its algorithms, which ultimately must form the definitive statement of its function. Without further revealing any algorithms that might be considered trade secrets, the manufacturer of the BIS monitor should be encouraged to release the device software in its original format to place BIS-related academic literature on a firm theoretical foundation and to promote further academic development of EEG monitoring algorithms.
Networked Health Care Governance in the European Union
Authors: Martinsen Dorte Sindbjerg , Schrama Reini 
Published: October 2020

AbstractThe European Union (EU) increasingly resorts to new forms of governance to establish unified health and welfare policies without member states having to transfer their sovereignty to a supranational level. European Administrative Networks are important instruments in the toolbox of new forms of governance, dealing with rulemaking, rule monitoring, and rule enforcement. Operating beyond, but not above, the state, European networks of national administrative units allow for interaction and exchange to coordinate national responses to increased interaction across their borders. The authors use social network analysis to uncover the pattern of interaction among national representatives in two central EU health care networks. Their analysis finds not only that the network in the area of pharmacovigilance has more competences, resources, and capacity to improve the enforcement of EU rules than the network regarding cross-border health care but also that the driving forces behind network interaction appear to differ quite a bit as well. While the supranational character becomes apparent in the former network, network interactions in the latter seem aimed at mitigating the impact of patient mobility rather than improving cross-border health care take up.
The developing heart: from The Wizard of Oz to congenital heart disease
Authors: Bruneau Benoit G. 
Published: October 2020

ABSTRACT
The heart is an essential organ with a fascinating developmental biology. It is also one of the organs that is most often affected in human disease, either during development or in postnatal life. Over the last few decades, insights into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart, exemplifying the importance of understanding the mechanistic underpinnings that lead to the development of an organ.
The rate of patient deferral and barriers to going forward with elective orthopaedic surgery during the COVID-19 pandemic
Authors: Clement Nicholas D. , Oussedik Sam , Raza Kamran I. , Patton Robyn F. L. , Smith Karen , Deehan David J. 
Published: October 2020

Aims The primary aim was to assess the rate of patient deferral of elective orthopaedic surgery and whether this changed with time during the coronavirus disease 2019 (COVID-19) pandemic. The secondary aim was to explore the reasons why patients wanted to defer surgery and what measures/circumstances would enable them to go forward with surgery. Methods Patients were randomly selected from elective orthopaedic waiting lists at three centres in the UK in April, June, August, and September 2020 and were contacted by telephone. Patients were asked whether they wanted to proceed or defer surgery. Patients who wished to defer were asked seven questions relating to potential barriers to proceeding with surgery and were asked whether there were measures/circumstances that would allow them to go forward with surgery. Results There was a significant decline in the rate of deferral for surgery from April (n = 38/50, 76%), June (n = 68/233, 29%), to August (n = 6/50, 12%) and September (n = 5/100, 5%) (p < 0.001). Patients wishing to defer were older (68 years (SD 10.1) vs 65 (SD 11.9)), more likely to be female (65% (44/68) vs 53% (88/165)) and waiting for a knee arthroplasty (65% (44/68) vs 41% (67/165); p < 0.001). By September 2020, all patients that deferred in June at one centre had proceeded or wanted to proceed with surgery due to a perceived lower risk of acquiring COVID-19 perioperatively (68%, n = 15) or because their symptoms had progressed (32%, n = 7). The most common reason (n = 14/17, 82%) for patients deferring surgery in September was the perceived risk of acquiring COVID-19 while as an inpatient. When asked what measures or circumstances would enable them to proceed with surgery, the most common (n = 7, 41%) response was reassurance of a COVID-19 free hospital. Conclusion The rate of deferral fell to 5% by September, which was due to a lower perceived risk of contracting COVID-19 perioperatively or worsening of symptoms while waiting. The potential of a COVID-19-free hospital and communication of mortality risk may improve a patient’s willingness to go forward with surgery. Cite this article: Bone Joint Open 2020;1-10:663–668.
Educación inclusiva y TIC: un análisis de las percepciones y prácticas docentes
Authors: Sanahuja Ribés Aida , Moliner Miravet Lidón , Alegre Ansuategui Francisco José 
Published: October 2020

INTRODUCCIÓN. Este trabajo analiza las percepciones y prácticas docentes hacia la educación inclusiva y las TIC. MÉTODO. En este estudio participaron un total de 161 personas en formación o ya tituladas en Educación Infantil, Educación Primaria, Educación Secundaria, Pedagogía y Psicología. Se utilizó el método de encuesta y como instrumento se empleó un cuestionario previamente validado en otra investigación que consta de cuatro factores: implicaciones didácticas, desarrollo profesional, actitud y práctica docente. Se llevaron a cabo diferentes análisis de los datos por factores, sexo, situación de empleo y años de experiencia en el campo utilizando análisis de regresión simple, análisis de varianza (ANOVA) y pruebas t de Student. RESULTADOS. Los principales resultados de este estudio evidencian que existe una percepción global hacia las TICaltamente positiva. Se detectaron diferencias importantes entre los factores que conforman el cuestionario. Las puntuaciones más elevadas se detectaron en los factores de implicaciones didácticas y desarrollo profesional, siendo estos factores los que ejercían como predictores de las percepciones y prácticas a nivel global. Los resultados indican que las personas con experiencia en el uso de las TIC en este campo están mucho más de acuerdo que las personas sin experiencia en que las TIC posibilitan la creatividad e innovación docente. DISCUSIÓN. Se constató que la inversión en TIC por parte de la Administración educativa constituye una elevada fuente de debate y que variables como los años de experiencia laboral justifican el diferente pensar de las personas encuestadas.
Self-cleaning structural colors by TiO2/Ti nanostructures
Authors: Shukla Gaurav , Subramanian Angappane 
Published: October 2020

Structural colors are fascinating due to their stability in comparison with dyes and pigments; nevertheless, environmental pollutants contaminate surfaces and redefine structural colors. To overcome this problem, cleaning of the surface is necessary at regular intervals, which is cumbersome and costly. We have circumvented this issue in this article and fabricated scalable self-cleaning structural colors. The structural colors are generated by

TiO

2

nanorods and thin films on Ti sputtered glass and flexible polyethylene terephthalate substrates employing a glancing angle deposition (GLAD) technique. Theoretical calculations based on thin film interference validate the experimental results and suggest Al, Ni, Co, and Cu as an alternative of Ti for generating structural colors. Structural colors are transformed to a superhydrophilic state, i.e., a self-cleaning state, via UV exposure and annealing at elevated temperatures. In addition to a self-cleaning state, annealing could control the opaqueness and color tunability of the structural colors. A permanent wettability state in between the superhydrophobic and superhydrophilic states of the structural colors is controlled by the GLAD technique. Moreover, the structural colors are demonstrated for information encryption and optical ethanol sensing applications.
Hybrid wideband multipath self-interference cancellation with an LMS pre-adaptive filter for in-band full-duplex OFDM signal transmission
Authors: Zheng Lizhuo , Liu Zhiyang , Xiao Shilin , Fok Mable P. , Zhang Zhiyi , Hu Weisheng 
Published: October 2020

A wideband multipath self-interference cancellation (SIC) system employing both dual-drive Mach–Zehnder modulator-based analog SIC and least mean square (LMS) algorithm-based pre-adaptive filter digital SIC is proposed and demonstrated for the cancellation of multipath self-interference (SI) and facilitation of in-band full-duplex (IBFD) orthogonal frequency-division multiplexing (OFDM) signal transmission. The multipath effect is an unavoidable challenge in SIC due to the dynamic and unpredictable properties in each path, as well as the need for separate matching components for compensating for each path. In this Letter, an LMS algorithm-based adaptive filter is used as a pre-equalizer to adapt and generate the matching signal to the closest approximate of the multipath SI signal. The adaptation is based on the minimization of the error signal generated from the matching signal and multipath SI signal in the LMS algorithm. With the introduction of the LMS adaptive filter to the analog SIC, an additional 9 dB cancellation improvement is obtained, resulting in a total of 32 dB cancellation depth over a cancellation bandwidth of 2.7 GHz at a center frequency of 1.65 GHz. To the best of our knowledge, the achieved performance is by far the widest cancellation bandwidth in a multipath SIC system, which is essential in a large bandwidth and high data rate transmission system. With the help of the proposed LMS adaptive filter digital SIC assisted analog SIC located at the remote node, power-efficient IBFD transmission of an OFDM signal through a 25 km fiber is experimentally demonstrated with a 6 dB bit error rate and 8% error vector magnitude improvements.
Broadly and finely tunable hybrid silicon laser with nanosecond-scale switching speed
Authors: Stern Brian , Kim Kwangwoong , Calò Cosimo , Fortin Catherine , Lanteri Delphine , Mekhazni Karim , Provost Jean-Guy , Wilk Arnaud , Mallécot Franck , Pommereau Frédéric , Melikyan Argishti , Dong Po 
Published: October 2020

We demonstrate a hybrid silicon tunable laser with wide tunability and rapid switching speed for applications in sensing and optical networks. By implementing an optimized carrier injection phase shifter design, the filters of the silicon laser cavity may be efficiently controlled, enabling both fine and broad wavelength tuning across a 56 nm range, in addition to a rapid 10 ns switching time. The laser emits up to 10 dBm output power, and the linewidth is near 200 kHz. The fast wavelength switching demonstrated here may be employed in data center and access networks, while the potential for rapid wavelength sweeping is attractive for optical sensing and imaging applications.
Photonic generation of multiband and multi-format microwave signals based on a single modulator
Authors: Wang Lu , Li Guangyi , Hao Tengfei , Zhu Sha , Li Ming , Zhu Ninghua , Li Wei 
Published: October 2020

We report a photonic scheme to generate multiband and multi-format microwave signals based on a commercial dual-polarization Mach–Zehnder modulator (DP-MZM). The key novelty of this work is the compact signal generator benefitting from the single modulator and the flexible multi-format signals at the multiband. The upper Mach–Zehnder modulator (MZM) of the DP-MZM is used to generate an optical frequency comb, while the lower MZM is driven by baseband electrical coding or single-chirp signal to obtain the multi-format modulated optical signal. The proposed scheme is theoretically analyzed and experimentally demonstrated. A multiband phase-coded microwave signal with a bit rate of 2 Gb/s and complementary linearly chirped microwave waveform pairs with a time duration of 1 µs and a bandwidth of 2 GHz have been successfully generated. The performance of pulse compression of generated signals is also demonstrated.
Powstawanie i dojrzewanie podstawowej wspólnoty kościelnej na przykładzie misji Masomeloka (w diecezji Toamasina na Madagaskarze)
Authors: ŻUKOWSKI WALDEMAR 
Published: October 2020

Powstawanie i dojrzewanie podstawowej wspólnoty kościelnej na przykładzie misji Masomeloka (w diecezji Toamasina na Madagaskarze)
Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke
Authors: Facchin Laura , Schöne Cornelia , Mensen Armand , Bandarabadi Mojtaba , Pilotto Federica , Saxena Smita , Libourel Paul Antoine , Bassetti Claudio L.A. , Adamantidis Antoine R. 
Published: October 2020

Functional recovery after stroke is associated with a remapping of neural circuits. This reorganization is often associated with low-frequency, high-amplitude oscillations in the peri-infarct zone in both rodents and humans. These oscillations are reminiscent of sleep slow waves (SW) and suggestive of a role for sleep in brain plasticity that occur during stroke recovery; however, direct evidence is missing. Using a stroke model in male mice, we showed that stroke was followed by a transient increase in NREM sleep accompanied by reduced amplitude and slope of ipsilateral NREM sleep SW. We next used 5 ms optical activation of Channelrhodopsin 2-expressing pyramidal neurons, or 200 ms silencing of Archeorhodopsin T-expressing pyramidal neurons, to generate local cortical UP, or DOWN, states, respectively, both sharing similarities with spontaneous NREM SW in freely moving mice. Importantly, we found that single optogenetically evoked SW (SWopto) in the peri-infarct zone, randomly distributed during sleep, significantly improved fine motor movements of the limb corresponding to the sensorimotor stroke lesion site compared with spontaneous recovery and control conditions, while motor strength remained unchanged. In contrast, SWoptoduring wakefulness had no effect. Furthermore, chronic SWoptoduring sleep were associated with local axonal sprouting as revealed by the increase of anatomic presynaptic and postsynaptic markers in the peri-infarct zone and corresponding contralesional areas to cortical circuit reorganization during stroke recovery. These results support a role for sleep SW in cortical circuit plasticity and sensorimotor recovery after stroke and provide a clinically relevant framework for rehabilitation strategies using neuromodulation during sleep.SIGNIFICANCE STATEMENTBrain stroke is one of the leading causes of death and major disabilities in the elderly worldwide. A better understanding of the pathophysiological mechanisms underlying spontaneous brain plasticity after stroke, together with an optimization of rehabilitative strategies, are essential to improve stroke treatments. Here, we investigate the role of optogenetically induced sleep slow waves in an animal model of ischemic stroke and identify sleep as a window for poststroke intervention that promotes neuroplasticity and facilitates sensorimotor recovery.