bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2
Authors: Sato Ko , Kumar Amarjeet , Hamada Keisuke , Okada Chikako , Oguni Asako , Machiyama Ayumi , Sakuraba Shun , Nishizawa Tomohiro , Nureki Osamu , Kono Hidetoshi , Ogata Kazuhiro , Sengoku Toru 
Published: December 2020

SummaryDimethylated histone H3 Lys36 (H3K36me2) regulates gene expression by antagonizing the repressive effect of polycomb-group proteins. Aberrant upregulation of H3K36me2, either by overexpression or point mutations of NSD2/MMSET, an H3K36 dimethyltransferase, is found in various cancers, including multiple myeloma. To understand the mechanism underlying its regulation, here we report the cryo-electron microscopy structure of the catalytic fragment of NSD2 bound to the nucleosome at 2.8 Å resolution. The nucleosomal DNA is partially unwrapped at superhelix location +5.5, facilitating the access of NSD2 to H3K36. NSD2 interacts with DNA and H2A along with H3. The autoinhibitory loop of NSD2 changes its conformation upon nucleosome binding to accommodate H3 in its substrate-binding cleft. Kinetic analysis revealed two oncogenic mutations, E1099K and T1150A, to aberrantly activate NSD2 by increasing its catalytic turnover but not the nucleosome affinity. Molecular dynamics simulations suggested that in both mutants, the autoinhibitory loop adopts an open state that can accommodate H3 more often than the wild type. We propose that E1099K and T1150A destabilize the interactions that keep the autoinhibitory loop closed, thereby enhancing the catalytic turnover. Our analyses would guide the development of specific inhibitors of NSD2 for the treatment of various cancers.
Universal grey number theory for the uncertainty presence of wiper structural system
Authors: Liang Zhiqiang , Liu Xintian , Yansong Wang , Wang Xiaolan 
Published: December 2020

Purpose
This study aims to accurately evaluate the influence of various error intervals on the performance of the wiper.

Design/methodology/approach
The wiper structural system is decomposed into classical four-link planar for kinematics analysis, and it was modeled respectively by using interval method, universal grey number theory and enumeration approach depending on the nature of uncertainty.

Findings
The universal grey number theory is a viable methodology for the accurate analysis of uncertain structural system.

Originality/value
(1) The model of uncertain wiper structural system is established. (2) Universal grey number theory and new parameters are adopted to analyze the presence of uncertain wiper structural system. (3) Comparative analysis of response quantities is obtained by interval method, universal grey number theory and enumeration method.
Improved multi-objective cuckoo search algorithm with novel search strategies for point-to-point part feeding scheduling problems of automotive assembly lines
Authors: Zhou Binghai , Li Xiujuan , Zhang Yuxian 
Published: December 2020

Purpose
This paper aims to investigate the part feeding scheduling problem with electric vehicles (EVs) for automotive assembly lines. A point-to-point part feeding model has been formulated to minimize the number of EVs and the maximum handling time by specifying the EVs and sequence of all the delivery tasks.

Design/methodology/approach
First, a mathematical programming model of point-to-point part feeding scheduling problem (PTPPFSP) with EVs is presented. Because the PTPPFSP is NP-hard, an improved multi-objective cuckoo search (IMCS) algorithm is developed with novel search strategies, possessing the self-adaptive Levy flights, the Gaussian mutation and elite selection strategy to strengthen the algorithm’s optimization performance. In addition, two local search operators are designed for deep optimization. The effectiveness of the IMCS algorithm is verified by dealing with the PTPPFSP in different problem scales.

Findings
Numerical experiments are used to demonstrate how the IMCS algorithm serves as an efficient method to solve the PTPPFSP with EVs. The effectiveness and feasibility of the IMCS algorithm are validated by approximate Pareto fronts obtained from the instances of different problem scales. The computational results show that the IMCS algorithm can achieve better performance than the other high-performing algorithms in terms of solution quality, convergence and diversity.

Research limitations/implications
This study is applicable without regard to the breakdown of EVs. The current research contributes to the scheduling of in-plant logistics for automotive assembly lines, and it could be modified to cope with similar part feeding scheduling problems characterized by just-in-time (JIT) delivery.

Originality/value
Both limited electricity capacity and no earliness and tardiness constraints are considered, and the scheduling problem is solved satisfactorily and innovatively for an efficient JIT part feeding with EVs applied to in-plant logistics.
Opening up to startup collaborations: open business models and value co-creation in SMEs
Authors: Ghezzi Antonio , Cavallo Angelo , Sanasi Silvia , Rangone Andrea 
Published: December 2020

Purpose
This study aims at exploring how small and medium enterprises (SMEs) can implement a more open and co-creational business model by actively collaborating with startups.

Design/methodology/approach
Because of the novelty of the SME–startup collaboration phenomenon and to the depth of the investigation required to grasp the mechanisms and logic of an open and co-creational business model, a single-case study has been performed related to investigating a collaboration between an SME and a startup.

Findings
The authors provide detailed empirical evidence on how SMEs may structure a “systematic” approach to design and execute an open business model enabled by startup collaboration. Moreover, this study suggests that the business model innovation process represents a necessary forerunner of an open business model. Finally, the authors contend that research on open business models should entail a broader perspective beyond the innovation process, to include business model validation through testing approaches like the lean startup.

Originality/value
This study takes as the locus of investigation the original perspective of the external partner of a focal firm willing to innovate. This study offers a unique contribution because, to date, few studies adopted such view within a relevant and under-remarked empirical setting linking SMEs and innovative startups.
Efficient VLSI architecture for FIR filter design using modified differential evolution ant colony optimization algorithm
Authors: John Tintu Mary , Chacko Shanty 
Published: December 2020

Purpose
This paper aims to concentrate on an efficient finite impulse response (FIR) filter architecture in combination with the differential evolution ant colony algorithm (DE-ACO). For the design of FIR filter, the evolutionary algorithm (EA) is found to be very efficient because of its non-conventional, nonlinear, multi-modal and non-differentiable nature. While focusing with frequency domain specifications, most of the EA techniques described with the existing systems diverge from the power related matters.

Design/methodology/approach
The FIR filters are extensively used for many low power, low complexities, less area and high speed digital signal processing applications. In the existing systems, various FIR filters have been proposed to focus on the above criterion.

Findings
In the proposed method, a novel DE-ACO is used to design the FIR filter. It focuses on satisfying the economic power utilization and also the specifications in the frequency domain.

Originality/value
The proposed DE-ACO gives outstanding performance with a strong ability to find optimal solution, and it has got quick convergence speed. The proposed method also uses the Software integrated synthesis environment (ISE) project navigator (p.28xd) for the simulation of FIR filter based on DE-ACO techniques.
Effect of thickness on optoelectronic properties of ITO thin films
Authors: Mazur Michał , Pastuszek Roman , Wojcieszak Damian , Kaczmarek Danuta , Domaradzki Jarosław , Obstarczyk Agata , Lubanska Aneta 
Published: December 2020

Purpose
Indium tin oxide (ITO) is a material belonging to the group of transparent conductive oxides, which are widely used in many fields of technology including optoelectronics and photovoltaics. However, the properties of ITO thin films depend on many factors. Therefore, the aim of the study was thorough investigation of the properties of sputtered ITO thin films of various thicknesses.

Design/methodology/approach
ITO coatings were deposited by magnetron sputtering in pure argon atmosphere using ceramic ITO target. Various deposition times resulted in obtaining thin films with different thickness, which had significant influence on the optoelectronic properties of deposited coatings. In this work the results of investigation of structural, surface, optical and electrical properties were presented.

Findings
Increase of the coating thickness caused change of the microstructure from amorphous to nanocrystalline and occurrence of grains with a size of 40 to 60 nm on their surface. Moreover, the fundamental absorption edge was red-shifted, whereas the average transmission in the visible wavelength range remained similar. Increase of the thickness caused considerable decrease of the sheet resistance and resistivity. It was found that even thin films with a thickness of 10 nm had antistatic properties.

Originality/value
The novelty and originality of presented work consists in, among other, determination of antistatic properties of ITO thin films with various sheet resistances that are in the range typical for dielectric and semiconducting material. To date, there are no reports on such investigations in the literature. Reported findings might be very helpful in the case of, for example, construction of transparent antireflective and antistatic multilayers.
A comparative study of satisfaction evaluation between students of mid-rise and high-rise student housing
Authors: Nazarpour Mohammad-Taghi , Norouzian-Maleki Saeid 
Published: December 2020

Purpose
The purpose of the current research is to examine the student’s residential satisfaction (SRS) of dormitories in Tehran and Shiraz. Providing homes for non-native students is considered as one of the key issues in university development.

Design/methodology/approach
A combination of qualitative and quantitative measurements (mixed methods) was used to compare some of the design features between middle-rise and high-rise student housing. Questionnaire forms were distributed between male students of “Shahid Beheshti University” and “Shiraz University” dormitories. Cluster sampling is done among residential blocks in each university. Students assessed perceived attributes of dormitories by indicating their satisfaction from different categories. The obtained data were analysed by SPSS software and the Mann-Whitney test.

Findings
Findings show that although in comparing two samples with only some of the criteria, Shahid Beheshti University dormitory was ranked higher, generally Shiraz University dormitory was more successful in meeting resident’s satisfaction. Among the physical features, the pleasant views and landscape are important components which are related to aesthetic preferences.

Research limitations/implications
More research examining student/environment interactions is needed to pay close attention to cultural aspects. The consideration of culturally diverse individuals in the assessment may also provide valuable insight into the students’ residential satisfaction.

Practical implications
In sum, the design implications resulting from the data analysis act as a step toward an evidence-based design approach. Housing designers can integrate the research findings with design solutions. They take active part in the design process by developing new methodologies to highlight their role in creating high-quality student housing.

Originality/value
The relationship between students and their residential environment has been a mainstream topic in environmental psychology. Some previous studies have focused on socio-demographic characteristics, whereas others have dealt with the physical characteristics of the student housing that affect SRS.
Identifying and prioritizing delay factors in Iran’s oil construction projects
Authors: Kazemi Aliyeh , Kim Eun-Seok , Kazemi Mohammad-Hossein 
Published: December 2020

Purpose
Successful implementation of construction projects is one of the crucial factors for the economic development of every country. The main part of the countries’ capital is allocated to civil and infrastructure projects annually, most of which are accomplished with delay. Construction projects are often criticized for overrunning time and budgets. Analyzing the factors causing delay is essential for omitting them and timely implementation of these projects. Due to the importance of oil projects, this study aims to investigate and analyze the factors causing a delay in Iran’s oil construction projects.

Design/methodology/approach
In this research, after a broad literature review, using the fuzzy Delphi method, a total of 75 delay factors were identified under 11 major categories of owner, contractor, consultant, equipment, labor, materials, design, contract and contractual relations, laws and regulations, environmental factors, and managerial factors. Then, by using the best-worst method, the factors were prioritized.

Findings
The results showed that sanction, governmental management systems, weak project management by the contractor, technical and managerial weaknesses of the consultant, financial problems and delay in payment by the owner, low efficiency of the equipment, low productivity of the workforce, changes in laws and regulations, inappropriate organizational structure linking to the project, changes in the design, and changes in the price of materials are the most crucial factors causing a delay in Iran’s oil construction projects.

Research limitations/implications
These findings are expected to have significant contributions to Iran’s oil construction industry in controlling the time overruns in construction contracts.

Originality/value
The main contribution of this study is to develop a comprehensive framework in which, causes of delay in Iran’s oil construction projects are addressed and prioritized.
Evaluation of energy sources based on sustainability factors using integrated fuzzy MCDM approach
Authors: Saraswat Santosh K. , Digalwar Abhijeet K. 
Published: December 2020

Purpose
The purpose of this paper is to develop an integrated fuzzy multi-criteria decision-making (MCDM) model for evaluation of the energy alternates in India based on their sustainability.

Design/methodology/approach
A fuzzy analytical hierarchy process approach is used for the weight calculation of the criteria and the fuzzy technique for order preference by similarity to the ideal solution is used for ranking of the energy alternates. Seven energy sources – thermal, gas power, nuclear, solar, wind, biomass and hydro energy are considered for the assessment purpose on the basis of sustainability criteria, namely, economic, technical, social, environmental, political and flexible.

Findings
The result of the analysis shows that economics is the highest weight criterion, followed by environmental and technical criteria. Solar energy was chosen as the most sustainable energy alternate in India, followed by wind and hydro energy.

Research limitations/implications
Few other MCDM techniques such as VIseKriterijumska Optimizacija I Kompromisno Resenje (multi-criteria optimization and compromise solution), weighted sum method and preference ranking organization method for enrichment evaluations – II can also be explored for the sustainability ranking of the energy alternates. However, the present model has also provided a good result.

Practical implications
The present research work will help the decision-makers and organizations in the evaluation and prioritizing the various energy sources on the scale of sustainability.

Social implications
Research finding provides guidance to government and decision-makers regarding the development of social conditions through energy security, job creation and economic benefits.

Originality/value
Research work can be act as a supplement for the investors and decision-makers specifically in prioritizing the investment perspective and to support other multi-perspective decision-making problems.
“That’s not a man’s drink”. The construction of gendered identities through stories of wine consumption in Kenya
Authors: Clifton Tim , Clifton Jonathan , Velikova Natalia 
Published: December 2020

PurposeThe purpose of this paper is to explore how gendered wine-drinker identities are constructed through stories of wine consumption in Kenya.Design/methodology/approachThe data comes from a corpus of 19 in-depth semi-structured interviews collected in Nairobi, Kenya. Taking a narrative approach, this paper uses positioning theory as a fine-grained linguistic methodological tool to analyze stories of gendered wine consumption.FindingsA key finding of the study is that wine consumption can enact, and be enacted by, wider normative societal gendered discourses of what men and women should and, should not, be drinking. In short, in some societies (Kenya being an example here) men drinking wine is subject to the normative gaze of their peers; and if men drink wine, they are not considered “real men.” This is so even when chatting up women, in which case male wine-drinkers are ascribed to the subordinate male identities of either the “new man” or the romantic man. However, male wine-drinkers can retain a real man identity if they are wealthy (and powerful) enough not to care what other men think.Practical implicationsThe study provides new insights for targeting consumers in emerging export markets. Wine companies need to be aware that the purchase drivers in established markets may not be central to consumers in developing markets. In developing markets, wine consumption may be influenced by the normative gaze of peers which enacts, and is enacted by, societal gendered discourses. Crucially, a thorough understanding of consumer behavior leads to a more critical consideration for focused marketing strategies aimed at establishing relationships with customers in developing markets.Originality/valueThe study offers an original contribution to the barely existent body of knowledge on wine consumption in sub-Saharan Africa and gendered wine-drinking identity construction. Additionally, from a methodological perspective, no previous study on wine consumption has used a narrative identity approach to the fine-grained linguistic analysis of transcripts of stories elicited during research interviews.
Strong alien or weak acquaintance? The effect of perceived institutional distance and cross-national uncertainty on ownership level in foreign acquisitions
Authors: Askarzadeh Fatemeh , Yousefi Hamed , Forghani Bajestani Mahdi 
Published: December 2020

PurposeFocusing on the direction of foreign acquisition, this study aims to differentiate the effect of institutional distance on the level of ownership. The authors identify several theoretical and methodological issues that might account for the inconsistencies in the literature and provide remedies accordingly. Specifically, the authors propose perceived institutional distance as a conceptualization of distance that controls for asymmetric uncertainty.Design/methodology/approachThe authors test the framework with ordinary least squares regression for a sample of 14,192 firm-entries in 115 target countries over 2007–2017.FindingsThe authors find that institutional distance shows a negative effect on equity ownership in all-inclusive global samples, while there are two imbalanced opposite effects if direction is considered. This casts doubt on the validity of studies that ignore direction. The authors suggest that multinational enterprises entering countries with lower-quality institutions tend to perceive more pronounced distance effects than those expanding the other way around. Hence, the authors argue that “perceived institutional distance” better explains the functional role of distance than simple distance.Practical implicationsThis study better delineates the link between distance and uncertainty and enhances managerial insights for entry mode selection. For policy-making purposes, the authors also show that improvement in institutional quality has a different effect on foreign resource commitment in developed and developing countries.Originality/valueTo the best of authors’ knowledge, this is the first study that considers both directionality and imbalance in institutional distance and proposes a measure to control for non-linear asymmetric relationship between distance and ownership. The authors extend the institutional theory and show the superiority of perceived institutional distance in predicting ownership implications.
How teams perform under emergent and dynamic situations: the roles of mental models and backup behaviors
Authors: Zhou Zikai , Pazos Pilar 
Published: December 2020

Purpose
The purpose of this study is to evaluate the roles of team mental models (TMMs) and backup behaviors for teams operating under emergent and dynamic situations. Specifically, the authors used a biased-corrected bootstrapping approach to assess the mediation effects of backup behaviors between the similarity of TMMs and team performance.

Design/methodology/approach
TMMs are a representation of the common understanding and beliefs in terms of task requirements or teamwork skills among different team members. It has wide implementations in various teams that are required to adapt quickly to an emergent and dynamic environment. The construct of TMMs has been studied extensively in previous literature, indicating a strong relationship between TMMs and team performance. However, how TMMs affect team performance under emergent and dynamic situations is only partially understood.

Findings
The findings of this study suggest that the similarity of task-focused mental models positively affects team performance through the mediation effects of backup behaviors. In contrast, the similarity of team-focused mental models does not positively affect backup behaviors and team performance.

Originality/value
This study contributes to the TMMs literature by investigating how teams perform in an emergent and dynamic environment. It not only provides theoretical support to the similarity of TMMs–backup behaviors–team performance relationships but has important implications in terms of team training and decision-making for teams operating under such conditions.