bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism
Authors: O’Leary Brianne R. , Alexander Matthew S. , Du Juan , Moose Devon L. , Henry Michael D. , Cullen Joseph J. 
Published: October 2020

AbstractPharmacological ascorbate (P-AscH−, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH− have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease burden. The purpose of this study was to determine the effects of P-AscH− on metastatic PDAC. Several in vitro and in vivo mechanisms involved in PDAC metastases were investigated following treatment with P-AscH−. Serum from PDAC patients in clinical trials with P-AscH− were tested for the presence and quantity of circulating tumor cell-derived nucleases. P-AscH− inhibited invasion, basement membrane degradation, decreased matrix metalloproteinase expression, as well as clonogenic survival and viability during exposure to fluid shear stress. In vivo, P-AscH− significantly decreased formation of ascites, tumor burden over time, circulating tumor cells, and hepatic metastases. Both in vitro and in vivo findings were reversed with the addition of catalase suggesting that the effect of P-AscH− on metastatic disease is mediated by hydrogen peroxide. Finally, P-AscH− decreased CTC-derived nucleases in subjects with stage IV PDAC in a phase I clinical trial. We conclude that P-AscH− attenuates the metastatic potential of PDAC and may prove to be effective for treating advanced disease.
Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths
Authors: Moozhipurath Rahul Kalippurayil , Kraft Lennart , Skiera Bernd 
Published: October 2020

AbstractPrior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths. We apply a fixed-effect log-linear regression model to a panel dataset of 152 countries over 108 days (n = 6524). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables and isolate the UVI effect from potential confounding factors. After controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] and a 1.0 percentage points decline in the CFR daily growth rate [p < 0.05]. These results represent a significant percentage reduction in terms of daily growth rates of cumulative COVID-19 deaths (− 12%) and CFR (− 38%). We find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention would be very attractive.
Tracheal development after left pulmonary artery reimplantation: an individual study
Authors: Hong Xiaoyang , Li Ruijie , Zhao Zhe , Guan Jiangheng , Wang Hui , Wang Gang , Liu Xiaohong , Yu Qin , Li Jun , Zhou Gengxu , Feng Zhichun 
Published: October 2020

AbstractPulmonary artery sling (PA sling) often presents as a life-threatening condition requiring urgent surgical correction. We reported 32 cases of PA sling in children who were followed up postoperatively in the past 6 years. All patients with PA slings who were admitted to the hospital from January 2012 to December 2017 and underwent surgery were retrospectively analyzed. The mean age of the 32 patients at repair was 16.97 months (range, 15 days to 128 months). Six patients required ventilator assistance for respiratory failure. All children underwent left pulmonary artery (LPA) reimplantation (n = 32), and 3 patients needed reimplantation slide tracheoplasty (n = 3) due to ventilation weaning failure. Four patients died, 27 patients survived until discharge, and 18 patients were followed up. Pulmonary computed tomography imaging and echocardiography were performed in 18 patients who were followed up. After LPA reimplantation, the tracheal carina area was significantly enlarged compared to that preoperation (p = 0.0002). In this follow-up cohort study, 75% of the patients who underwent LPA reimplantation survived until discharge. The survivors had subsequently well-developed pulmonary arteries and tracheas.
Photocatalyzed reductive fluoroalkylation of 2-acetoxyglycals towards the stereoselective synthesis of α-1-fluoroalkyl-C-glycosyl derivatives
Authors: Mora Flores Erwin W. , Uhrig María Laura , Postigo Al 
Published: October 2020

A benign, efficient, regio- and stereoselective protocol for the syntheses of α-1-fluoroalkyl-C-glycosyl compounds bearing CF3, C4F9, and C6F13 substituents on the anomeric carbon has been developed.
miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease
Authors: Li Ni , Zhu Linwen , Zhou Hua , Zheng Dawei , Xu Guodong , Sun Lebo , Gao Jianqing , Shao Guofeng 
Published: October 2020

Abstract
To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PBMCs and THP-1 cell models. The binding of miR-1183 and Bcl-2 gene was confirmed by luciferase activity test. We also measured expression levels of BCL-2 in heart valve tissue from patients with RHD using ELISA and immunohistochemistry. In silico analysis and reporter gene assays indicated that miR-1183 directly targets the mRNA encoding BCL-2. It is found that miR-1183 binds directly to the 3′UTR of the BCL-2 mRNA and down-regulates the mRNA and protein levels of BCL-2. Overexpression of miR-1183 in RHD patients and cell lines down-regulated BCL-2 expression and induced apoptosis. With the progression of the disease, the expression of BCL-2 in the heart valve tissue of patients with RHD decreased. MiRNA-1183 is up-regulated in RHD and induces cardiac myocyte apoptosis through direct targeting and suppression of BCL-2, both of which might play important roles in RHD pathogenesis. During the compensatory period of RHD, up-regulated miR-1183 destroyed the balance of apoptosis proteins (Bax and BAK) in Bcl-2 family, enhance the apoptosis cascade reaction and reduce the anti apoptosis effect. The significantly higher expression levels of miR-1183 appear to play distinct roles in RHD pathogenesis by regulation BCL-2, possibly affecting myocardial apoptosis and remodeling in the context of RHD.
Characterizing galaxy clusters by their gravitational potential: Systematics of cluster potential reconstruction
Authors: Tchernin C. , Lau E. T. , Stapelberg S. , Hug D. , Bartelmann M. 
Published: October 2020

Context. Biases in mass measurements of galaxy clusters are one of the major limiting systematics in constraining cosmology with clusters.
Aims. We aim to demonstrate that the systematics associated with cluster gravitational potentials are smaller than the hydrostatic mass bias and that cluster potentials could therefore be a good alternative to cluster masses in cosmological studies.
Methods. Using cosmological simulations of galaxy clusters, we compute the biases in the hydrostatic mass (HE mass) and those in the gravitational potential, reconstructed from measurements at X-ray and millimeter wavelengths. In particular, we investigate the effects of the presence of substructures and of nonthermal pressure support on both the HE mass and the reconstructed potential.
Results. We find that the bias in the reconstructed potential (6%) is less than that of the HE mass (13%) and that the scatter in the reconstructed potential decreases by ∼35% with respect to that in the HE mass.
Conclusions. This study shows that characterizing galaxy clusters by their gravitational potential is a promising alternative to using cluster masses in cluster cosmology.
Vergessene Heilpflanzen
Authors: Latté Klaus Peter 
Published: October 2020

ZusammenfassungPflanzen wurden zu allen Zeiten der Menschheit als Lebensmittel und als Arzneimittel angewendet. In der Antike und später im Mittelalter wurden zahlreiche Pflanzen und deren arzneiliche Verwendung beschrieben. Aus verschiedenen Gründen, u. a. das Aufkommen von synthetischen Wirkstoffen ab dem 19. Jahrhundert, ist das Wissen um pflanzliche Arzneimittel zum Teil verloren gegangen. In diesem Beitrag wird der Weg vom Altertum bis zur heutigen Zeit anhand von fünf Arzneipflanzen bzw. -drogen, Blutweiderichkraut, Tormentillwurzelstock, Alantwurzel, Leberblümchenkraut und den Knollen des Blauen Eisenhut verfolgt und deren derzeitige Anwendung betrachtet.
Mechanical and Metabolic Responses during High-intensity Training in Elite 800-m Runners
Authors: Bachero-Mena Beatriz , González-Badillo Juan José 
Published: October 2020

AbstractThe purpose of this study was to describe the mechanical and metabolic
responses of a typical high-intensity training session in high-level 800-m
athletes. Nine male high-level 800-m athletes (personal best
1:43–1:56 min:ss) performed a typical high-intensity
interval training session consisting of 5×200 m with
4 min rest. Countermovement jump and blood lactate were measured at
rest and after each running bout. Running times, ground contact times, and
stride length were also measured. Running times and lactate (p<0.01)
progressively increased from the first to the last running bout. Jump height
(p<0.01) and stride length (p<0.05) progressively decreased
from the first running bout to the last. A significant negative relationship
(p<0.001; r =−0.83) was found between the individual
values of jumping height and blood lactate concentration; and a significant
positive relationship (p<0.01; r=0.67) was observed between
the time in the 200 m and the contact times. In conclusion, the
results demonstrated that the typical training session performed by 800-m
athletes produced a high level of fatigue as evidenced by significant
alterations in the mechanical and metabolic response. The impairments
observed in the mechanical and metabolic parameters may indirectly reflect a
state of energy deficit of the muscle contractile machinery and a reduction
of the force-generating capacity.
Re-Opening Exercise Science Laboratories and Testing During the Covid-19 Endemic Phase
Authors: Dengel Donald R , Evanoff Nicholas G 
Published: October 2020

AbstractThe coronavirus disease 2019 (COVID-19) pandemic has forced primary/grade schools and university closings as well as forced the suspension of a number of medical and laboratory testing procedures. Exercise science laboratories whether in clinical, research or educational locations were also forced to pause testing procedures. As the COVID-19 pandemic begins to subside in some areas of the world, exercise science laboratories are contemplating how to create a safe environment to resume some laboratory testing activities. In this article, we present suggestions for how exercise science laboratories can open and create a safe environment for subjects, laboratory personnel and equipment upon reopening.
Procalcitonin Level at 24 Hours of Age May be Predictive for Transient Tachypnea of the Newborn
Authors: Tarakcı Nuriye , Altunhan Hüseyin , Sarı Eyüp , Uyar Mehmet 
Published: October 2020

Abstract
Objective It is an important problem to differentiate transient tachypnea of the newborn (TTN) from bacterial pneumonia or other conditions in patients admitted to Neonatal Intensive Care Unit. The aim of this study was to evaluate the predictive value of procalcitonin (PCT) for TTN.
Methods A total of 52 infants were contained in the study. The patients were divided into three groups. Group 1 consisted of patients with pronounced grunting at more than 2 hours postnatal age (n = 16). Group 2 consisted of patients whose grunt was reduced or gone at 2 hours postnatal age but in whom tachypnea persisted until 24 hours postnatal age (n = 18). Group 3 consisted of patients with minimal or no respiratory distress at 24 hours postnatal age (n = 18). In all groups, PCT concentrations were determined at birth and 24 hours postnatal age.
Results PCT concentrations at birth were significantly higher in Group 1 than other groups, but there was no difference between Groups 2 and 3. PCT concentrations at 24 hours postnatal age were significantly higher in Groups 1 and 2 than Group 3. No difference was found between Group 1 and Group 2 at 24 hours postnatal age. All PCT concentrations in Group 3 were significantly lower than other groups. PCT thresholds for the diagnosis of TTN were 0.44 ng/mL at birth (sensitivity 58%, specificity 50%) and 5.11 ng/mL at 24 hours postnatal age (sensitivity 79.4%, specificity 89.1%).
Conclusion Serial PCT measurements at birth and postnatal 24 hours may be helpful in differentiating between pneumonia and TTN. Further researches are needed to confirm this initial study.
Impact of geometric factors of roughness on the dewetting dynamics of a liquid film in the Wenzel state
Authors: Wang Lei , Wang Xiang , Peng Ze-Rui 
Published: October 2020

Abstract
An axisymmetric two-phase lattice Boltzmann method is adopted to simulate the dewetting dynamics of the liquid film on a substrate fabricated with different types of roughness: pillar-type, nail-type and mushroom-type. The liquid film remains in the Wenzel or half-Wenzel state. The dewetting of the liquid film occurs after generating an initial dry spot on the substrate and forming a contact line between the liquid film, gases and the substrate. The dewetting is characterized by the continuous size growth of the contact line’s radius. The effect of the geometric factors of the roughnesses on the dewetting dynamics is analyzed in detail. For the pillar-type roughness, three dewetting modes, named ‘no residual,’ ‘part residual’ and ‘full residual’, are identified, and a mode map that depends on the geometrical factors is given. For the nail-type roughness, the dewetting process is found to be clearly restrained. For the mushroom-type roughness, only the ‘full residual’ mode is found, and the depth of the grooves hardly affects the dewetting speed, if the liquid film remains in the Wenzel state; but if it remains in the half-Wenzel state, the liquids would be brought out completely from the grooves and thus result in a faster dewetting speed under smaller penetration of the liquid film. The results indicate that the different geometric elements of the roughness could affect the dewetting speed to different degrees. Determining how the structured roughness affects the dewetting speed can help the industry control the dewetting process of the liquid film.
Microbubbles with optical fiber tips chemically worn
Authors: Villegas-Sanchez G , Cerecedo-Nuñez H H , Garcia-Ramirez J I , Padilla-Sosa P , Marin-Hernandez A 
Published: October 2020

Abstract
This research shows an experimental study and analysis on microbubbles formation, through the use of chemically modified optical fiber tips. Microbubbles are formed in highly absorbent liquid using a continuous wave laser at 980 nm, with conventional powers. This report is considered, as the first study and dynamic analysis for microbubble formation in solution with these particular types of tips. Fiber tips are modified by the chemical wear method, using hydrofluoric acid, while, microbubbles are generated with the help of the deposition or adhesion of nanostructures on the modified tips. We have used carbon nanotubes dissolved in ethanol as nanostructures. We present an analysis of the results considering: the growth curves of the microbubbles, the largest radii, the lifetime and the growth rate. Finally, we discuss the important features of results, suggesting a possible way to control the size and number of microbubbles. Furthermore, the results of our research could be useful to improve the proposals of earlier applications or to propose new ones. The results shown can be useful for new applications or to improve proposals.
Orientation of adsorbed polar molecules (dipoles) in external electrostatic field
Authors: Gabovich A M , Voitenko A I 
Published: October 2020

Abstract
A model is proposed in the framework of classical electrostatics to describe the behavior of an adsorbed polar molecule near the plane interface between two insulators under the action of an external electrostatic field. The molecule is considered as a permanent point dipole that polarizes the interface and interacts with it through electrostatic image forces. The latter and the applied field try to reorient the dipole in a competitive manner. The system behavior turns out to be rather complicated: it may show a bistable character with a hysteresis (a switch). Such a switch can serve as an element in a memory network made of adsorbed molecules.
An efficient flexible strain sensor based on anhydride-grafted styrene-butadiene-styrene triblock copolymer/carbon black: enhanced electrical conductivity, sensitivity and stability through solvent swelling
Authors: Wu Lanlan , Yao Dahu , Gao Xiping , Yu Zhiqiang , Wang Xiao , He Yuxin , Zhu Yan , Lu Chang , Li Keyang 
Published: October 2020

Abstract
High-performance flexible strain sensors based on maleic anhydride-grafted styrene-butadiene-styrene triblock copolymer/carbon black (SBS-g-MAH/CB) composites were prepared by simple solvent swelling of SBS-g-MAH/CB composites obtained by melt blending. After swelling in N,N-dimethylformamide (DMF) or xylene, the aggregation of CB in the composites was reduced noticeably. Consequently, the conductivity of the composites improved by a great extent, and the percolation thresholds of the composites decreased. At 12% CB loading, the conductivity increased approximately 400 times or 6000 times upon swelling in DMF or xylene, respectively. DMF swelling did not change the morphology of SBS-g-MAH, and a three-dimensional conductive network was formed in the composites. The SBS-g-MAH morphology changed considerably, and a two-dimensional conductive network was formed after swelling in xylene. DMF swelling enhanced the piezoresistive performance of the composites. The gauge factor increased from 4 to 71. Moreover, the drawbacks of composites prepared by melt blending, including electromechanical inconsistency and poor stability, were overcome. Due to the high conductivity and the change in SBS-g-MAH morphology, an approximately two-fold increase in electromagnetic interference shielding efficiency was observed after swelling the composites in xylene. The mechanism of the strain sensor was discussed. The strain sensing behaviour of SBS-g-MAH/CB composites can be explained by an analytical model based on the tunneling theory.
Fluctuating Cooper pairs in FeSe at temperatures exceeding double T

c
Authors: Solovjov A L , Petrenko E V , Omelchenko L V , Nazarova E , Buchkov K , Rogacki K 
Published: October 2020

Abstract
Temperature dependencies of excess conductivity,

σ
′

, have been studied in detail for three FeSe0.94 textured polycrystalline samples prepared by partial melting and solid state reaction. It was revealed that both

σ
′

and its temperature dependence are extremely sensitive to the method of sample preparation. Then, it was shown that in the range from the superconducting transition temperature T

c
~9 K up to the characteristic temperature T
01 ~19 K,

σ
′

(
T
)

obeys the classical fluctuation theories of Aslamazov–Larkin (AL) and Hikami-Larkin (Maki-Thompson (MT) term) pointing to the existence of fluctuating Cooper pairs in FeSe at temperatures exceeding double T

c
. Like in cuprates, AL–MT crossover at

T
0

<

T

01

is observed, which means the appearance of 3D–2D dimensional transition at this temperature. This allows us to determine the coherence length along the c-axis, ξ

c
(0) ~3 Å, and a set of additional samples’ parameters, including the phase relaxation time,

τ

ϕ

, of fluctuating Cooper pairs (FCPs), within a simple two-dimensional free-carrier picture. It was shown that

τ

ϕ

in FeSe coincides with that found for YBa2Cu3O

7
−
δ

suggesting that the nature of superconducting fluctuations is very similar for these high-temperature superconductors of different types.
Retracted: MHD Darcy-Forchheimer flow due to gyrotactic microorganisms of Casson nanoparticles over a stretched surface with convective boundary conditions
Authors: Islam Saeed , Jawad Muhammad , Saeed Anwar , Zubair Muhammad , Khan Arshad , Ahmad Syed Sheraz , Shah Zahir , Alrabaiah Hussam 
Published: October 2020

Abstract
In the current article, the augmentation of heat transmission for non-Newtonian Casson nanoparticles is investigated with motile gyrotactic microorganisms, magnetohydrodynamic (MHD), and thermal radiation upon a stretched sheet. An extended Darcy-Forchheimer model along with convective boundary conditions is also applied to the flow system. To convert these coupled nonlinear fluid flow expressions into ordinary differential expression, the concept of similarity transformation is employed. The modified coupled nonlinear set of differential expression is solved analytically by employing the HAM technique. The mathematical program Mathematica is used to manage the complexities of computations. It is established in this study that the velocity distribution is reducing the function of the inertial, porosity, and magnetic parameters. Additionally, the motile density of microorganisms displays diminishing conduct for developing estimations of bioconvection Lewis and Peclet numbers. It is further established in this study that there is an augmentation in Nusselt number and skin friction coefficient with a corresponding increase in nonlinear radiation and magnetic parameters. In order to ensure the validity of the HAM solution, we have determined numerical solutions for modeled equations with the help of boundary conditions by using ND-Solve in Mathematica-10. It is established that there is pretty fine concurrence between both solutions that ensure the validity of our solution by HAM.