bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smaller pineal gland is associated with rapid eye movement sleep behavior disorder in Alzheimer’s disease
Authors: Park Jeongbin , Suh Seung Wan , Kim Grace Eun , Lee Subin , Kim Jun Sung , Kim Hye Sung , Byun Seonjeong , Bae Jong Bin , Kim Jae Hyoung , Kim Sang Eun , Han Ji Won , Kim Ki Woong 
Published: November 2020

Abstract
Background
To investigate the association between pineal gland volume and symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) in Alzheimer’s disease (AD) patients without any feature of dementia with Lewy bodies.

Methods
We enrolled 296 community-dwelling probable AD patients who did not meet the diagnostic criteria for possible or probable dementia with Lewy bodies. Among them, 93 were amyloid beta (Aβ) positive on 18F-florbetaben amyloid brain positron emission tomography. We measured RBD symptoms using the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) and defined probable RBD (pRBD) as the RBDSQ of 5 or higher. We manually segmented pineal gland on 3T structural T1-weighted brain magnetic resonance imaging.

Results
The participants with pRBD had smaller pineal parenchyma volume (VPP) than those without pRBD (p <  0.001). The smaller the VPP, the more severe the RBD symptoms (p <  0.001). VPP was inversely associated with risk of prevalent pRBD (odds ratio = 0.909, 95% confidence interval [CI] = 0.878–0.942, p <  0.001). Area under the receiver operator characteristic curve for pRBD of VPP was 0.80 (95% CI = 0.750–0.844, p <  0.0001). These results were not changed when we analyzed the 93 participants with Aβ-positive AD separately.

Conclusions
In AD patients, reduced pineal gland volume may be associated with RBD.
Measuring financial literacy with a Situational Judgement Test: do some groups really perform worse or is it the measuring instrument?
Authors: Wuttke Eveline , Siegfried Christin , Aprea Carmela 
Published: November 2020

AbstractDue to current trends in society and economy, financial literacy is often considered as an important twenty-first century skill. However, regardless of the postulated relevance, studies suggest that financial illiteracy seems to be a widespread phenomenon in the population of many nations. Some studies also show that some groups perform particularly poorly (e.g. women, persons with migration background and/or low level of education). These differences are often attributed to different individual characteristics such as abilities, dispositions or socialisation patterns. However, available research also suggests that even after controlling for them, a quite large portion of the performance differences between the various groups of test-takers remains unexplained. One explanation for performance gaps in financial literacy might be that differences in test scores could also be evoked by the test instruments itself and may thus, at least in part, be interpreted as testing bias. In this paper, we present a newly developed Situational Judgement Test, which is focused on financial competence. For this test, we examine whether differences between groups are attributable to individual differences or due to a test bias. To analyse a possible test bias, we tested one facet of financial literacy (with three factors: control of one’s financial situation, budgeting and handling of money) related to everyday money management for measuring invariance for different groups. If measuring invariance could be assumed, we analysed group differences by calculating t-tests. Results show that two factors of the test show measurement invariance for all groups considered (gender, migration and educational background, opportunities to learn). Group comparisons are thus possible and potential differences are not due to a test bias. For one factor, we can only assume measurement invariance for the group with/without migration background and with/without opportunities to learn in financial topics. When we look at group differences, we find that in contrast to the findings of many previous studies, the analysis of the mean differences does not show any systematic deficits in financial literacy for specific groups.
A Three-Dimensional Bioabsorbable Tissue Marker for Volume Replacement and Radiation Planning: A Multicenter Study of Surgical and Patient-Reported Outcomes for 818 Patients with Breast Cancer
Authors: Kaufman Cary S. , Cross Michael J. , Barone Julie L. , Dekhne Nayana S. , Devisetty Kiran , Dilworth Joshua T. , Edmonson David A. , Eladoumikdachi Firas G. , Gass Jennifer S. , Hall William H. , Hong Robert L. , Kuske Robert R. , Patton Brandon J. , Perelson Carol , Phillips Rogsbert F. , Smith Arnold B. , Smith Linda A. , Tafra Lorraine , Lebovic Gail S. 
Published: November 2020

Abstract
Background
Accurate identification of the tumor bed after breast-conserving surgery (BCS) ensures appropriate radiation to the tumor bed while minimizing normal tissue exposure. The BioZorb® three-dimensional (3D) bioabsorbable tissue marker provides a reliable target for radiation therapy (RT) planning and follow-up evaluation while serving as a scaffold to maintain breast contour.

Methods
After informed consent, 818 patients (826 breasts) implanted with the BioZorb® at 14 U.S. sites were enrolled in a national registry. All the patients were prospectively followed with the BioZorb® implant after BCS. The data collected at 3, 6, 12, and 24 months included all demographics, treatment parameters, and provider/patient-assessed cosmesis.

Results
The median follow-up period was 18.2 months (range, 0.2–53.4 months). The 30-day breast infection rate was 0.5 % of the patients (n = 4), and re-excision was performed for 8.1 % of the patients (n = 66), whereas 2.6 % of the patients (n = 21) underwent mastectomy. Two patients (0.2 %) had local recurrence. The patient-reported cosmetic outcomes at 6, 12, and 24 months were rated as good-to-excellent by 92.4 %, 90.6 %, and 87.3 % of the patients, respectively and similarly by the surgeons. The radiation oncologists reported planning of target volume (PTV) reduction for 46.2 % of the patients receiving radiation boost, with PTV reduction most commonly estimated at 30 %.

Conclusions
This report describes the first large multicenter study of 818 patients implanted with the BioZorb® tissue marker during BCS. Radiation oncologists found that the device yielded reduced PTVs and that both the patients and the surgeons reported good-to-excellent long-term cosmetic outcomes, with low adverse effects. The BioZorb® 3D tissue marker is a safe adjunct to BCS and may add benefits for both surgeons and radiation oncologists.
Assessment of criterion validity of personality disorder diagnosis in adolescents and relations between attachment style and personality disorder diagnosis
Authors: Lenkiewicz Kamila , Konowałek Łukasz , Bryńska Anita 
Published: November 2020

Cel pracyCel: ocena trafności kryterialnej oraz stabilności w czasie diagnozy zaburzeń osobowości u młodzieży oraz związków między stylem przywiązania a rozpoznaniem zaburzeń osobowości.MetodaMateriał i metoda: 50 nastolatków (46 dziewcząt oraz 4 chłopców) w wieku 15-17 lat, hospitalizowanych w oddziale psychiatrii dzieci i młodzieży, przebadano przy pomocy ustrukturyzowanego wywiadu SCID-II i Inwentarza Przywiązania do Rodziców i Rówieśników (IPPA). Powtórną ocenę wywiadem SCID-II przeprowadzono po upływie roku w grupie osób spełniających kryteria diagnostyczne dla zaburzeń osobowości w pomiarze 1WynikiWyniki: w pomiarze 1 kryteria diagnostyczne dla różnych rodzajów zaburzeń osobowości potwierdzono u 41 (82%) adolescentów (średnia liczba kryteriów =5.9). Najczęściej potwierdzano kryteria dla zaburzeń osobowości typu borderline (n=26; średnia liczba kryteriów =7.9). W pomiarze 2 przebadano 21 osób (51%), średnia ilość potwierdzonych kryteriów wyniosła =6.6. Wykazano istotny statystycznie związek pomiędzy ilością kryteriów diagnostycznych dla zaburzeń osobowości w pomiarze 1 i ilością kryteriów w pomiarze 2 (r=0.58, p<0.010). U 82% badanych nastolatków z zaburzeniami osobowości stwierdzono pozabezpieczny styl przywiązania z matką, przy czym w grupie spełniającej kryteria dla zaburzeń osobowości typu borderline dominował lękowo-unikający styl przywiązania (83%).WnioskiWnioski: Cechy zaburzeń osobowości w wieku nastoletnim, szczególnie typu borderline, są trwałe na przestrzeni roku..
Managing BVDV at the herd level part 1
Authors: Button Ellie 
Published: November 2020

Bovine viral diarrhoea virus (BVDV) is a costly disease and its eradication is the focus of the English voluntary scheme, BVDFree. The process of identifying a farm as negative or not negative is broken down into four stages using ADAM: assess disease risk; define herd status; action plan for BVD control; monitor progress. This process is based on the long-established protocols defined by Cattle Health Certification Standards. The first two stages are discussed in this article with the others following in part 2 of this series. The risk assessment for current infection should focus on incoming animals to the herd, boundary fences and existing vaccination programmes. Suitable testing can then follow with a choice of newborn screening or youngstock cohort surveillance, with optional bulk milk analysis in dairy herds. Farms that show initial evidence of endemic BVDV infection can undertake further testing to discover the source.
Randomized, Placebo Controlled Trial of Experimental Hookworm Infection for Improving Gluten Tolerance in Celiac Disease
Authors: Croese John , Miller Gregory C. , Marquart Louise , Llewellyn Stacey , Gupta Rohit , Becker Luke , Clouston Andrew D. , Welch Christine , Sidorenko Julia , Wallace Leanne , Visscher Peter M. , Remedios Matthew L. , McCarthy James S. , O'Rourke Peter , Radford-Smith Graham , Loukas Alex , Norrie Mark , Masson John W. , Gearry Richard B. , Rahman Tony , Giacomin Paul R. 
Published: November 2020

INTRODUCTION:
Celiac disease is an autoimmune disorder where intestinal immunopathology arises after gluten consumption. Previous studies suggested that hookworm infection restores gluten tolerance; however, these studies were small (n = 12) and not placebo controlled.

METHODS:
We undertook a randomized, placebo-controlled trial of hookworm infection in 54 people with celiac disease. The 94-week study involved treatment with either 20 or 40 Necator americanus third-stage larvae (L3-20 or L3-40) or placebo, followed by escalating gluten consumption (50 mg/d for 12 weeks, 1 g intermittent twice weekly for 12 weeks, 2 g/d sustained for 6 weeks, liberal diet for 1 year).

RESULTS:
Successful study completion rates at week 42 (primary outcome) were similar in each group (placebo: 57%, L3-20: 37%, and L3-40: 44%; P = 0.61), however gluten-related adverse events were significantly reduced in hookworm-treated participants: Median (range) adverse events/participant were as follows: placebo, 4 (1–9); L3-20, 1 (0–9); and L3-40, 0 (0–3) (P = 0.019). Duodenal villous height:crypt depth deteriorated similarly compared with their enrolment values in each group (mean change [95% confidence interval]: placebo, −0.6 [−1.3 to 0.2]; L3-20, −0.5 [−0.8 to 0.2]; and L3-40, −1.1 [−1.8 to 0.4]; P = 0.12). A retrospective analysis revealed that 9 of the 40 L3-treated participants failed to establish hookworm infections. Although week 42 completion rates were similar in hookworm-positive vs hookworm-negative participants (48% vs 44%, P = 0.43), quality of life symptom scores were lower in hookworm-positive participants after intermittent gluten challenge (mean [95% confidence interval]: 38.9 [33.9–44] vs 45.9 [39.2–52.6]).

DISCUSSION:
Hookworm infection does not restore tolerance to sustained moderate consumption of gluten (2 g/d) but was associated with improved symptom scores after intermittent consumption of lower, intermittent gluten doses.
Correlation for Predicting Heat Transfer Characteristics of A Helical Oscillating Heat Pipe (HOHP) at Normal Operating Conditions
Authors: Donmuang Amorn , Chompookham Teerapat 
Published: November 2020

The helical oscillating heat pipe (HOHP) is a high heat transfer heat exchanger with high flexibility in its installation and can therefore be used in a wide variety of applications. In this study, the effect of various parameters on the heat transfer rates of HOHP were used to establish a correlation equation for use in the heat flux prediction, the dimensionless parameters studied were rv/rl, Bo, Nu, We, Ja, Pr, Fr, Co, Ga, Bi, Wo, Oh, and Ku. Experiments were conducted to find out their effects on the heat transfer rates of copper HOHP with internal diameters were 2.03, 3.5, and 4.5 mm. The lengths of evaporator and condenser sections were equal at 1500, 2000, and 2500 mm. The pitch coils were 10, 15, and 20 mm. The working fluids used were R134a, ethanol, and water with the filling ratios were 30%, 50%, and 80% of the total internal volume. The temperature of evaporator section were varied between 60, 70, and 80°C within normal operating conditions in a vertical position. The results of the experiment showed that the internal diameter, lengths of evaporator/condenser sections, pitch coil, type of working fluid, filling ratio and temperature of evaporator section affected the heat transfer rates of the HOHP. The results of dimensionless parameters can establish the correlation equation to predict the heat flux for the HOHP as shown in this paper. In addition, the results of this research can be applied in the designing and construction of HOHP heat exchangers.
Clonal spread of PER-1 and OXA-23 producing extensively drug resistant Acinetobacter baumannii during an outbreak in a burn intensive care unit in Tunisia
Authors: Mabrouk Aymen , Chebbi Yosra , Raddaoui Anis , Krir Asma , Messadi Amen Allah , Achour Wafa , Thabet Lamia 
Published: November 2020

AbstractExtensively drug resistant Acinetobacter baumannii (XDR-Ab), has emerged as an important pathogen in several outbreaks. The aim of our study was to investigate the eventual genetic relatedness of XDR-Ab strains recovered from burn patients and environment sites in the largest Tunisian Burn Intensive Care Unit (BICU) and to characterize β-lactamase encoding genes in these strains. Between March 04th, 2019 and April 22nd, 2019 an outbreak of XDR-Ab was suspected. Environmental screening was done. All isolates were screened by simplex PCR for β-lactamase genes. Genetic relatedness was determined by pulsed field gel electrophoresis (PFGE) of ApaI-digested total DNA. During the study period, 21 strains of A. baumannii were isolated in burn patients, mainly in blood culture (n = 7) and central vascular catheter (n = 6). All strains were susceptible to colistin but resistant to imipenem (n = 23), ciprofloxacin (n = 23), amikacin (n = 22), tigecyclin (n = 5) and rifampicin (n = 4). The blaOXA-51-like, blaOXA23, and blaADC genes were present in all strains. These resistance determinants were associated with blaPER-1 in 10 strains. The ISAba1 was inserted upstream of blaOXA-23 in all isolates. PFGE revealed two major clusters A (n = 11) and B (n = 5). This is the first description in Tunisia of clonally related PER-1 producing XDR-Ab in burn patients with probable environmental origin.
Anatomical changes of the thoracic vertebrae in asymptomatic individuals – A cross-sectional study
Authors: Valasek T. , Vágó E. , Danielisz ZS. , Babka M. , Kovács É. 
Published: November 2020

AbstractPurposeThe purpose of the present cross-sectional study is to examine the degree of degenerative patho-anatomical changes in the thoracic vertebrae in asymptomatic adult patients.Materials and MethodsA total of 150 adult patients were examined with computed tomography (CT) because of various health conditions (e.g., tumour risk). The images were revised with post-processing procedures to detect bony changes in the thoracic vertebrae. Three types of degenerations (osteophytes, arthrosis, and irregular endplates) were examined and graded using appropriate grading systems. Correlational investigations were carried out in relation to age, BMI, and degenerations. Moreover, to examine the value of the degenerations the frequencies of the grading categories were assessed in each segment.ResultsThe total number of the patients included was 41, who had no trunk symptoms. We found no convincing correlations in terms of age, BMI, and degenerations, however, age and facet joint arthrosis showed a tentative association. The degree of the degenerations was the largest in the Th7-8, Th8-9, Th9-10 segments for osteophytes, in the Th4-5, Th5-6 for arthrosis, and in the Th8-9, Th9-10 for irregular endplates.ConclusionsThis study found that there are several progressive degenerative changes in the thoracic spine without any clinical symptoms. Accordingly, it can be advised that clinicians should avoid labelling the disorders and planning their treatment based on the results of diagnostic imaging only.
Indications for ocular evisceration and orbital implant related complications in a tertiary eye hospital in Hungary over an 11-year period
Authors: Tóth G. , Szentmáry N. , Sándor G.L. , Csákány B. , Antus Z. , Pluzsik M.T. , Lukáts O. , Nagy Z.Z. 
Published: November 2020

AbstractPurposeOur aims were to evaluate the primary and clinical evisceration indications and to analyse orbital implant related complications.Materials/methodsWe included in our retrospective review all eviscerations between 2006 and 2016 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary. Primary evisceration indications were classified into six groups: trauma, surgical diseases, infections or inflammations, systemic diseases, tumours and unclassifiable diseases. Clinical immediate evisceration indications were also classified into six groups: painful blind eye due to glaucoma, atrophia/phthisis bulbi, endophthalmitis, cosmetic reasons, acute trauma and expulsive bleeding.ResultsEvisceration was performed in 46 eyes of 46 patients (54.3% males, age 43.0 ± 18.6 years). The most common primary evisceration indications were trauma (37%), surgical diseases (34.8%), infection or inflammation (10.9%), systemic diseases (6.5%), tumours (8.7%) and unclassifiable diseases (2.2%). Painful blind eye due to glaucoma (34.8%) was the most common clinical indication for evisceration, followed by atrophia/phthisis bulbi (26.1%), endophthalmitis (17.4%), cosmetic reasons (13.0%), acute trauma (6.5%) and expulsive bleeding (2.2%). After evisceration, 91.3% of the patients received orbital implant and during 26.8±28.9 months follow-up implant related complications were found in 14.3% of the cases, including implant extrusion (4.8%), partial wound dehiscence (4.8%), implant exposure (2.4%) and orbital inflammation (2.4%).ConclusionPainful blind eye and atrophia/phthisis bulbi due to ocular trauma and surgical diseases represent the most common indications for ocular evisceration. If malignant intraocular tumours can be excluded, evisceration surgery combined with a silicon-based orbital implant is a safe and effective procedure.
Knowledge, awareness, and usage of probiotics among Hungarian adults: An explorative survey
Authors: Havelda L. , Bencz Z. , Veresné Bálint M. 
Published: November 2020

AbstractPurposeThe aim of this study was to evaluate the use of probiotic products in Hungary, to explore consumers' knowledge of probiotics, and to gain information about the main characteristics of current usage.Materials and MethodsThe research used a self-developed explorative questionnaire to obtain the necessary information. The data collected was further analysed with IBM SPSS 25.0 and Microsoft Office Excel.ResultsNearly three-quarters of respondents (73.9%) have used probiotics in their life. Those who have already used these products, mostly heard about them from doctors (62.8%) and friends/relatives (40.5%), while among non-users the main sources of information were web pages (46.8%) and commercials (45.2%).ConclusionsWe found several differences between users and non-users in terms of probiotics awareness. Consequently, healthcare providers may play an important role in the process of careful product choice and proper usage.
<em>One Step at a Time: The Birth of the Christian Medical College, Vellore</em>, by Reena George. Roli Press, 2018
Authors: Tuckwell Gareth David 
Published: November 2020

‘One step at a time’ was written to mark the centenary of the founding of one of the foremost medical colleges in India. Behind so many remarkable institutions there lies a hidden story relating to their founding, their struggles to become established and the challenges faced in growing to maturity in our rapidly changing world.
As we journey through the second millennium with many well-established organisations straining at the leash of tradition and seeking fresh vitality and vision, it is important to look back to their founders and reflect on the lives of those who have been pioneers and teachers in the decades before. To be radical in moving forward, organisations benefit from drawing from their roots (radix: Latin) and allowing their strategies to be enriched through them. Hence this amazing book deserves to have a wider readership than just those many thousands who have passed through the Christian Medical College (CMC) Vellore.
Special Issue: COVID-19 as a Challenge on Many Fronts
Authors: Grills Nathan , Larson Elliott , O'Neill Daniel 
Published: November 2020

Editorial introducing the special issue on pandemic response, with these key resource links:

CCIH resources & forum: https://www.ccih.org/cpt_resources/covid-19/
CCIH survey: https://www.ccih.org/covid-19-response-survey-of-fbos/
Leadership consultations (HFAN): https://www.healthforallnations.com/
Book & mission blogs: https://www.medicalmissions.com/coronavirus
ICMDA Resource Links: https://mailchi.mp/a46dcc104406/covid01?
Joint Learning Initiative for Faith and Local Communities: https://jliflc.com/covid/
CUGH resources for educators and researchers: https://myemail.constantcontact.com/COVID-19-Newsletter-Vol--5.html?soid=1112846108446&aid=AUbGAK-oI_U

FBO resources from CDC: https://www.cdc.gov/coronavirus/2019-ncov/community/organizations/index.htm
Community health fact sheet (in 25 languages):https://protect-au.mimecast.com/s/8jexCP7yBlsK0MxPpUzK3Iv?domain=r20.rs6.net
El espejo quebrado: la sátira visual de Andrés Rábago, OPS
Authors: Puerto Francisco J. 
Published: November 2020

Este ensayo analiza las viñetas satíricas de OPS, alias de Andrés Rábago, actualmente conocido como El Roto, publicadas durante la Transición española. El ejercicio intelectual que suponen, su profundidad y capacidad interpretativa, las convierten en una herramienta privilegiada para adentrarse en la cultura transicional. Propongo que su falta de palabras las aísla, reforzando su invitación a la reflexión; su violencia hace visible la violencia subjetiva del régimen franquista; y su distopía trata de universalizarlas, subrayando su mensaje. Así, pretendo explorar nuevas vías para reflejar los relatos disidentes de la Transición mediante un artista que documenta el trauma latente tras el relato oficial.

Palabras clave: Sátira, Transición, Violencia, Imagen.
LUISA ELENA DELGADO, PURA FERNÁNDEZ Y JO LABANYI, EDS. Engaging the Emotions in Spanish Culture and History. Nashville: Vanderbilt University Press, 2016. 300 pp.
Authors: Gómez-Castellano Irene 
Published: November 2020

Reseña de Engaging the Emotions in Spanish Culture and History de LUISA ELENA DELGADO, PURA FERNÁNDEZ Y JO LABANYI, EDS.