bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uso de recursos didáticos em atividades de Modelagem Matemática: uma análise de relatos de experiência
Authors: Mendonça Adriana Ferreira , Borges Neto Hermínio 
Published: July 2020

Neste artigo busca-se identificar os recursos didáticos evidenciados em atividades de Modelagem Matemática e verificar em que situações eles são inseridos no planejamento docente. Definem-se, com efeito, as categorias recursos planejados e recursos emergentes. A pesquisa qualitativa, exploratória, de caráter bibliográfico, foi realizada em anais de dois congressos — Encontro Paranaense de Modelagem na Educação Matemática (EPMEM) e Conferência Nacional sobre Modelagem na Educação Matemática (CNMEM) — que têm a Modelagem Matemática como escolha de publicação, tomando-se os relatos de experiência. Os resultados mostram que diversos meios são utilizados pelos professores e, na maioria das vezes, planejados, mas, em algumas situações, emergem da necessidade da investigação no encaminhamento da atividade pelos estudantes, o que, neste caso, demanda do professor maior preparo e mais cuidado na condução de atividades de Modelagem.
Palavras-chave: Modelagem Matemática. Recursos Didáticos. Planejamento.
Stable and Selective Dehydrogenation of Methylcyclohexane using Supported Catalytically Active Liquid Metal Solutions – Ga52Pt/SiO2 SCALMS
Authors: Sebastian Oshin , Nair Sharanya , Taccardi Nicola , Wolf Moritz , Søgaard Alexander , Haumann Marco , Wasserscheid Peter 
Published: July 2020

AbstractThe use of gallium‐rich, Supported Catalytically Active Liquid Metal Solution (SCALMS) is a promising new concept to achieve catalysis with atomically dispersed active metal atoms. Expanding our previous work on short alkane dehydrogenation, we present here the application of SCALMS for the dehydrogenation of methylcyclohexane (MCH) to toluene (TOL) using a Ga52Pt alloy (liquid under reaction conditions) supported on silica. Cycloalkane dehydrogenation catalysis has attracted great attention recently in the context of hydrogen storage concepts using liquid organic hydrogen carrier (LOHC) systems. The system under investigation showed high activity and stable conversion of MCH at 450 °C and atmospheric pressure for more than 75 h time‐on‐stream (XMCH=15 %) with stable toluene selectivity (STOL) of 85 %. Compared to commercially available Pt/SiO2, the SCALMS system resulted in higher yields and robustness. Baseline experiments with Pt‐free Ga/SiO2 under identical conditions revealed the decisive influence of Pt dissolved in the liquid Ga matrix.
A lightweight anonymous two‐factor authentication protocol for wireless sensor networks in Internet of Vehicles
Authors: Sadri Mohammad Javad , Rajabzadeh Asaar Maryam 
Published: July 2020

SummaryInternet of Vehicles (IoV), as the next generation of transportation systems, tries to make highway and public transportation more secure than used to be. In this system, users use public channels for their communication so they can be the victims of passive or active attacks. Therefore, a secure authentication protocol is essential for IoV; consequently, many protocols are presented to provide secure authentication for IoV. In 2018, Yu et al proposed a secure authentication protocol for WSNs in vehicular communications and claimed that their protocol could satisfy all crucial security features of a secure authentication protocol. Unfortunately, we found that their protocol is susceptible to sensor capture attack, user traceability attack, user impersonation attack, and offline sink node's secret key guessing attack. In this paper, we propose a new authentication protocol for IoV which can solve the weaknesses of Yu et al's protocol. Our protocol not only provides anonymous user registration phase and revocation smart card phase but also uses the biometric template in place of the password. We use both Burrow‐Abadi‐Needham (BAN) logic and real‐or‐random (ROR) model to present the formal analysis of our protocol. Finally, we compare our protocol with other existing related protocols in terms of security features and computation overhead. The results prove that our protocol can provide more security features and it is usable for IoV system.
Toxic Mask-ulinity: The Link between Masculine Toughness and Affective Reactions to Mask Wearing in the COVID-19 Era
Authors: Palmer Carl L. , Peterson Rolfe D. 
Published: July 2020

AbstractThe COVID-19 pandemic has altered numerous elements of social, political, and economic life. Mask wearing is arguably an essential component of the new normal until substantial progress is made on a vaccine. However, though evidence suggests the practice is a positive for public health and limiting the transmission of COVID-19, there is variation in attitudes toward and practices of mask wearing. Specifically, there appears to be a sex-based divide in mask wearing, with men more likely to resist wearing masks. Utilizing an original survey, we test the correlation between masculinity and mask wearing. We find that identification with norms of masculinity has a significant influence on affective responses toward mask wearing.
Long non-coding RNA CCDC144NL-AS1 sponges miR-143-3p and regulates MAP3K7 by acting as a competing endogenous RNA in gastric cancer
Authors: Fan Hao , Ge Yugang , Ma Xiang , Li Zengliang , Shi Liang , Lin Linling , Xiao Jian , Chen Wangwang , Ni Peidong , Yang Li , Xu Zekuan 
Published: July 2020

AbstractGastric cancer (GC) has been one of the most leading cause of cancer-death worldwide. Long non-coding RNAs (lncRNAs) have been found to be related with the carcinogenesis and the development of various cancers, including GC. However, there are still many GC-related lncRNAs functional roles and molecular mechanisms that have not yet been clearly studied. Herein, we report lncRNA CCDC144NL-AS1, which has not been explored in GC, and it is markedly upregulated in GC tissues, which may serve as an independent predictor of poor prognosis. We found that CCDC144NL-AS1 expression was significantly positively associated with a larger tumor size and more pronounced lymph node metastasis. Through a series of in vivo and in vitro functional experiments, we observed that CCDC144NL-AS1 could facilitate cell proliferation, invasion and migration and inhibit cell apoptosis in GC. Further mechanism investigation revealed that CCDC144NL-AS1 acted as a competing endogenous RNA (ceRNA) for sponging miR-143-3p and upregulated the expression of its direct endogenous target MAP3K7 in GC. Taken together, our results elucidate the oncogenic roles of CCDC144NL-AS1/miR-143-3p/MAP3K7 axis in GC progression, providing inspiration for further understanding of the mechanism of GC and making CCDC144NL-AS1 as a potential novel diagnostic and therapeutic target for GC.
High-performance perovskite solar cell using photonic–plasmonic nanostructure
Authors: Tooghi Alireza , Fathi Davood , Eskandari Mehdi 
Published: July 2020

AbstractIn this paper, a coupled optical-electrical modeling method is applied to simulate perovskite solar cells (PSCs) to find ways to improve light absorption by the active layer and ensure that the generated carriers are collected effectively. Initially, a planar structure of the PSC is investigated and its optical losses are determined. To reduce the losses and enhance collection efficiency, a convex light-trapping configuration of PSC is used and the impacts of these nanostructures on all parts of the cell are investigated. In this convex nanostructured PSC, the power conversion efficiency (PCE) is found to be increased when the thickness of the absorbing layer remained unchanged. Then, a plasmonic reflector is applied to trap light inside the perovskite. In this structure, by scattering light through the surface plasmon resonance (SPR) effect of the Au back-contact, the electromagnetic field is found to concentrate in the active layer. This results in increased perovskite absorption and, consequently, a high current density of the cell. In the final structure, which is the integration of these two structures, optical losses are found to be greatly diminished and the short-circuit current density (Jsc) is increased from 18.63 mA/cm2for the planar structure to 23.5 mA/cm2for the proposed structure. Due to the increased Jscand open-circuit voltage (Voc) caused by the improved carrier collection, the PCE increases from 14.62 to 19.54%.
Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways
Authors: Kim Suhyeon , Hong Ki-Bae , Kim Singeun , Suh Hyung Joo , Jo Kyungae 
Published: July 2020

AbstractWe investigated the antidepressant effect of creatine (CRE) and taurine (TAU) mixtures on behavioural changes and biomarkers in stress-induced depression in Drosophila melanogaster and a mouse model. Following CRE/TAU mixture administration in the Drosophila model, depression-like state induced by vibration, locomotion, climbing activity, and survival rate were measured. The normal stress (NS) group demonstrated decreased movement than the control (CON) group; movements in the CRE/TAU-treated group (particularly 0.15/0.5%) returned to the CON levels. Antidepressant effects of CRE/TAU mixtures were confirmed in a depressive mouse model induced by chronic mild stress. In behavioural assessments, movement and sucrose preference of the CRE/TAU group increased to a similar level as in the positive control group; hippocampal catecholamine and serotonin levels increased significantly. Stress-related hormones (adrenocorticotropic and corticotropin-releasing hormones) and inflammatory factors (IL-1β, IL-6, and TNF-α) increased in the NS group but significantly decreased in the CRE/TAU-treated group. Brain signalling protein expression ratio of phosphorylated protein kinase B (p-Akt)/Akt, phosphorylated extracellular signal-regulated kinase (p-ERK)/ERK, and brain-derived neurotrophic factor (BDNF) significantly increased in the CRE/TAU-treated group. These results indicate that CRE/TAU-induced antidepressant effects are associated with increased behavioural patterns and downregulation of stress hormones and cytokines, mediated through Akt and ERK/BDNF pathways in vertebrate models.
A case study of floor failure characteristics under fully mechanised caving mining conditions in extra-thick coal seams
Authors: Zhang Pingsong , Ou Yuanchao , Sun Binyang , Liu Chang 
Published: July 2020

AbstractTo determine the failure characteristics and evolution regularity of the floor strata during fully mechanised top-coal cave mining in typical deep and extra-thick seams in western China, the 61303 working face of an Ordos mine was selected as the engineering research object. A comprehensive monitoring method combining a BOTDR (Brillouin Optical Time-Domain Reflection) distributed fiber strain test and a borehole resistivity CT (Computerised Tomography) test was adopted. The results show that floor stress distribution of the deep-buried and extra-thick coal seam is significantly affected by the different depths of rock lithology. At the interface of the rock strata with a large difference in the elastic modulus, phenomena such as the asynchronism of strata movement and obvious differences in failure easily occur. The failure depth of the floor strata in the 61303 working face is approximately 15.90 m, and the influence depth of the floor disturbance is approximately 32.70 m. Under the influence of the mining pressure, floor stress distribution and crack evolution have obvious spatial and temporal effects. In different inclined boreholes, the data captured by the cable have different values and the fracture locations of the cable also differ. Compared with a single borehole, multiple boreholes with different inclinations, directions and locations can provide more comprehensive and reliable data trends. The knowledge obtained by this monitoring can provide reference information for the study of floor damage under similar conditions and the formulation of technical measures such as those that prevent mine water disasters.
Circular economy: laying the foundations for conceptual and theoretical development in management studies
Authors: De Angelis Roberta 
Published: July 2020

PurposeThis article develops conceptual and paradigmatic clarity in the circular economy literature from a management studies perspective.Design/methodology/approachThis article uses a systematic literature review for analysing how circular economy is currently understood. It also reflects on how to establish paradigmatic anchoring of the circular economy in the management field.FindingsMultiple definitions of the circular economy exist, but they depict the circular economy narrowly and fail to incorporate aspects of competitiveness and profitability. Additionally, most of sustainability management research displays shortcomings in the way this literature frames the organisation–nature relationship.Research limitations/implicationsThis article aims to support conceptual and theoretical development in the circular economy literature and highlights opportunities for enhanced competitiveness and profitability deriving from circular business model innovation. However, further research is welcomed to assess this connection.Practical implicationsThe conceptualisation of the circular economy proposed in this study emphasises aspects of competitiveness and profitability, which is of relevance to management practitioners.Originality/valueThis study addresses current shortcomings in how the circular economy is conceptualised. As a result, it proposes a more comprehensive conceptualisation which also includes competitiveness and profitability aspects and, thereby, is relevant from a management studies perspective. It also provides paradigmatic anchoring to the circular economy concept by suggesting that the sustaincentric paradigm, which has received limited scholarly attention so far, is suitable to inform circular economy research and practice.
Circulating and tissue biomarkers as predictors of bromine gas inhalation
Authors: Juncos Juan Xavier Masjoan , Shakil Shazia , Ahmad Aamir , Aishah Duha , Morgan Charity J. , Dell'Italia Louis J. , Ford David A. , Ahmad Aftab , Ahmad Shama 
Published: July 2020

AbstractThe threat from deliberate or accidental exposure to halogen gases is increasing, as is their industrial applications and use as chemical warfare agents. Biomarkers that can identify halogen exposure, diagnose victims of exposure or predict injury severity, and enable appropriate treatment are lacking. We conducted these studies to determine and validate biomarkers of bromine (Br2) toxicity and correlate the symptoms and the extent of cardiopulmonary injuries. Unanesthetized rats were exposed to Br2 and monitored noninvasively for clinical scores and pulse oximetry. Animals were euthanized and grouped at various time intervals to assess brominated fatty acid (BFA) content in the plasma, lung, and heart using mass spectrometry. Bronchoalveolar lavage fluid (BALF) protein content was used to assess pulmonary injury. Cardiac troponin I (cTnI) was assessed in the plasma to evaluate cardiac injury. The blood, lung, and cardiac tissue BFA content significantly correlated with the clinical scores, tissue oxygenation, heart rate, and cardiopulmonary injury parameters. Total (free + esterified) bromostearic acid levels correlated with lung injury, as indicated by BALF protein content, and free bromostearic acid levels correlated with plasma cTnI levels. Thus, BFAs and cardiac injury biomarkers can identify Br2 exposure and predict the severity of organ damage.
Direct-Acting Oral Anticoagulants Versus Warfarin in Medicare Patients With Chronic Kidney Disease and Atrial Fibrillation
Authors: Wetmore James B. , Roetker Nicholas S. , Yan Heng , Reyes Jorge L. , Herzog Charles A. 
Published: July 2020

Background and Purpose:
The comparative effectiveness of direct-acting oral anticoagulants, compared with warfarin, for risks of stroke/systemic embolism, major bleeding, or death have not been studied in Medicare beneficiaries with atrial fibrillation and nondialysis-dependent chronic kidney disease.

Methods:
Medicare data from 2011 to 2017 were used to identify patients with stages 3, 4, or 5 chronic kidney disease and new atrial fibrillation who received a new prescription for warfarin, apixaban, rivaroxaban, or dabigatran. We estimated marginal hazard ratios with 95% CIs for the association of each direct-acting oral anticoagulant, compared with warfarin, for the outcomes of interest using inverse-probability-of-treatment weighted Cox proportional hazards models in as-treated and intention-to-treat analyses.

Results:
A total of 22 739 individuals met criteria (46.3% warfarin, 29.6% apixaban, 17.2% rivaroxaban, 6.9% dabigatran). Across the groups of anticoagulant users, mean age was 78.4 to 79.0 years; 50.3% to 51.4% were women, and 80.3% to 82.8% had stage 3 chronic kidney disease. In the as-treated analysis, for stroke/systemic embolism, hazard ratios, all compared with warfarin, were 0.70 (0.51–0.96) for apixaban, 0.80 (0.54–1.17) for rivaroxaban, and 1.15 (0.69–1.94) for dabigatran. For major bleeding, analogous hazard ratios were 0.47 (0.37–0.59) for apixaban, 1.05 (0.85–1.30) for rivaroxaban, and 0.95 (0.70–1.31) for dabigatran. There was no difference in the risk of all-cause mortality between the direct-acting oral anticoagulants and warfarin. Results of the intention-to-treat analysis were similar.

Conclusions:
Apixaban, compared with warfarin, was associated with decreased risk of stroke/systemic embolism and major bleeding; risks for both outcomes with rivaroxaban and dabigatran did not differ from risks with warfarin.
A Revised Computational Neuroanatomy for Motor Control
Authors: Haar Shlomi , Donchin Opher 
Published: July 2020

Abstract
We discuss a new framework for understanding the structure of motor control. Our approach integrates existing models of motor control with the reality of hierarchical cortical processing and the parallel segregated loops that characterize cortical–subcortical connections. We also incorporate the recent claim that cortex functions via predictive representation and optimal information utilization. Our framework assumes that each cortical area engaged in motor control generates a predictive model of a different aspect of motor behavior. In maintaining these predictive models, each area interacts with a different part of the cerebellum and BG. These subcortical areas are thus engaged in domain-appropriate system identification and optimization. This refocuses the question of division of function among different cortical areas. What are the different aspects of motor behavior that are predictively modeled? We suggest that one fundamental division is between modeling of task and body whereas another is the model of state and action. Thus, we propose that the posterior parietal cortex, somatosensory cortex, premotor cortex, and motor cortex represent task state, body state, task action, and body action, respectively. In the second part of this review, we demonstrate how this division of labor can better account for many recent findings of movement encoding, especially in the premotor and posterior parietal cortices.
The effect of short-course antibiotics on the resistance profile of colonizing gut bacteria in the ICU: a prospective cohort study
Authors: Munck Christian , Sheth Ravi U. , Cuaresma Edward , Weidler Jessica , Stump Stephania L. , Zachariah Philip , Chong David H. , Uhlemann Anne-Catrin , Abrams Julian A. , Wang Harris H. , Freedberg Daniel E. 
Published: July 2020

Abstract
Background
The need for early antibiotics in the intensive care unit (ICU) is often balanced against the goal of antibiotic stewardship. Long-course antibiotics increase the burden of antimicrobial resistance within colonizing gut bacteria, but the dynamics of this process are not fully understood. We sought to determine how short-course antibiotics affect the antimicrobial resistance phenotype and genotype of colonizing gut bacteria in the ICU by performing a prospective cohort study with assessments of resistance at ICU admission and exactly 72 h later.

Methods
Deep rectal swabs were performed on 48 adults at the time of ICU admission and exactly 72 h later, including patients who did and did not receive antibiotics. To determine resistance phenotype, rectal swabs were cultured for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). In addition, Gram-negative bacterial isolates were cultured against relevant antibiotics. To determine resistance genotype, quantitative PCR (qPCR) was performed from rectal swabs for 87 established resistance genes. Within-individual changes in antimicrobial resistance were calculated based on culture and qPCR results and correlated with exposure to relevant antibiotics (e.g., did β-lactam antibiotic exposure associate with a detectable change in β-lactam resistance over this 72-h period?).

Results
Of 48 ICU patients, 41 (85%) received antibiotics. Overall, there was no increase in the antimicrobial resistance profile of colonizing gut bacteria during the 72-h study period. There was also no increase in antimicrobial resistance after stratification by receipt of antibiotics (i.e., no detectable increase in β-lactam, vancomycin, or macrolide resistance regardless of whether patients received those same antibiotics). This was true for both culture and PCR. Antimicrobial resistance pattern at ICU admission strongly predicted resistance pattern after 72 h.

Conclusions
Short-course ICU antibiotics made little detectable difference in the antimicrobial resistance pattern of colonizing gut bacteria over 72 h in the ICU. This provides an improved understanding of the dynamics of antimicrobial resistance in the ICU and some reassurance that short-course antibiotics may not adversely impact the stewardship goal of reducing antimicrobial resistance.
The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study
Authors: Behrouz Vahideh , Dastkhosh Ali , Hedayati Mehdi , Sedaghat Meghdad , Sharafkhah Maryam , Sohrab Golbon 
Published: July 2020

Abstract
Background
Crocin as a carotenoid exerts anti-oxidant, anti-inflammatory, anti-cancer, neuroprotective and cardioprotective effects. Besides, the increasing prevalence of diabetes mellitus and its allied complications, and also patients' desire to use natural products for treating their diseases, led to the design of this study to evaluate the efficacy of crocin on glycemic control, insulin resistance and active adenosine monophosphate-activated protein kinase (AMPK) levels in patients with type-2 diabetes (T2D).

Methods
In this clinical trial with a parallel-group design, 50 patients with T2D received either 15-mg crocin or placebo, twice daily, for 12 weeks. Anthropometric measurements, dietary intake, physical activity, blood pressure, glucose homeostasis parameters, active form of AMPK were assessed at the beginning and at the end of the study.

Results
Compared with the placebo group, crocin improved fasting glucose level (P = 0.015), hemoglobin A1c (P = 0.045), plasma insulin level (P = 0.046), insulin resistance (P = 0.001), and insulin sensitivity (P = 0.001). Based on the within group analysis, crocin led to significant improvement in plasma levels of glucose, insulin, hemoglobin A1c, systolic blood pressure, insulin resistance and insulin sensitivity. The active form of AMPK did not change within and between groups after intervention.

Conclusions
The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D. Further studies are needed to confirm these findings.
Trial Registration This study has been registered at Clinicaltrial.gov with registration number NCT04163757