bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the implementation of a pharmacist-driven chronic obstructive pulmonary disease exacerbation orderset in an inpatient setting
Authors: Petite Sarah E , Murphy Julie A 
Published: May 2020

Abstract

Purpose
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines provide recommendations for the management of chronic obstructive pulmonary disease (COPD) exacerbation. Studies have demonstrated shortened hospital length of stay (LOS) with use of guideline-adherent systemic corticosteroid therapy. There are no published studies evaluating the impact of an inpatient orderset on patient-oriented outcomes.

Methods
This institutional review board–approved, retrospective, quasi-experimental, single-center cohort study included adult patients admitted to an internal medicine service for a documented COPD exacerbation from January 2014 through December 2015 (the pre-orderset group) or January 2017 through December 2018 (the post-orderset group). A pharmacy and therapeutics committee–approved orderset recommending guideline-adherent treatment with systemic corticosteroids, scheduled short-acting bronchodilators, and antibiotics was used in the post-orderset group. The primary outcome was hospital LOS. Secondary outcomes included 30-day all-cause and COPD-related readmission rates, systemic corticosteroid–related adverse events, and antibiotic use.

Results
A total of 358 unique patient encounters were identified for the pre-orderset group (n = 220) and post-orderset group (n = 138). The mean (SD) hospital LOS was significantly shorter in the post-orderset group (3.4 [2.4] days vs 4.3 [3.0] days; P = 0.004). There were no significant between-group differences in rates of 30-day all-cause and COPD-related readmissions. The overall rate of antibiotic use was lower in the post-orderset group vs the pre-orderset group (71% vs 90.2%; P &lt; 0.001). The rate of occurrence of new blood glucose elevation was significantly lower in the post-orderset group (49.3% vs 79.1%; P &lt; 0.001), with no significant between-group difference in occurrence of new blood pressure elevation.

Conclusion
A significant reduction in hospital LOS was found with the implementation of a pharmacist-driven COPD exacerbation orderset.
Mainstreaming Microbes across Biomes
Authors: Clarke Laurence J , Jones Penelope J , Ammitzboll Hans , Barmuta Leon A , Breed Martin F , Chariton Anthony , Charleston Michael , Dakwa Vongai , Dewi Fera , Eri Rajaraman , Fountain-Jones Nicholas M , Freeman Jules , Kendal Dave , McDougal Rebecca , Raes Eric J , Sow Swan Li San , Staples Timothy , Sutcliffe Brodie , Vemuri Ravichandra , Weyrich Laura S , Flies Emily J 
Published: May 2020

Abstract
Bacteria, fungi, and other microorganisms in the environment (i.e., environmental microbiomes) provide vital ecosystem services and affect human health. Despite their importance, public awareness of environmental microbiomes has lagged behind that of human microbiomes. A key problem has been a scarcity of research demonstrating the microbial connections across environmental biomes (e.g., marine, soil) and between environmental and human microbiomes. We show in the present article, through analyses of almost 10,000 microbiome papers and three global data sets, that there are significant taxonomic similarities in microbial communities across biomes, but very little cross-biome research exists. This disconnect may be hindering advances in microbiome knowledge and translation. In this article, we highlight current and potential applications of environmental microbiome research and the benefits of an interdisciplinary, cross-biome approach. Microbiome scientists need to engage with each other, government, industry, and the public to ensure that research and applications proceed ethically, maximizing the potential benefits to society.
Age-dependent Gender Differences in COVID-19 in Mainland China: Comparative Study
Authors: Qian Jie , Zhao Lin , Ye Run-Ze , Li Xiu-Jun , Liu Yuan-Li 
Published: May 2020

Abstract

Background
The ongoing pandemic of novel coronavirus disease 2019 (COVID-19) is challenging the global public health system. Sex differences in infectious diseases are a common but neglected problem.

Methods
We used the national surveillance database of COVID-19 in mainland China to compare gender differences in attack rate (AR), proportion of severe and critical cases (PSCC), and case fatality rate (CFR) in relation to age, affected province, and onset-to-diagnosis interval.

Results
The overall AR was significantly higher in females than in males (63.9 vs 60.5 per 1 million persons; P ˂ .001). In contrast, PSCC and CFR were significantly lower among females (16.9% and 4.0%) than among males (19.5% and 7.2%), with odds ratios of 0.87 and 0.57, respectively (both P ˂ .001). The female-to-male differences were age dependent, and were significant among people aged 50–69 years for AR and in patients aged 30 years or older for both PSCC and CFR (all P ≤ .001). The AR, PSCC, and CFR varied greatly from province to province. However, female-to-male differences in AR, PSCC, and CFR were significant in the epicenter, Hubei province, where 82.2% confirmed cases and 97.4% deaths occurred. After adjusting for age, affected province, and onset-to-diagnosis interval, the female-to-male difference in AR, PSCC, and CFR remained significant in multivariate logistic regression analyses.

Conclusions
We elucidate an age-dependent gender dimorphism for COVID-19, in which females have higher susceptibility but lower severity and fatality. Further epidemiological and biological investigations are required to better understand the sex-specific differences for effective interventions.
COVID-19 Outbreaks in US Immigrant Detention Centers: The Urgent Need to Adopt CDC Guidelines for Prevention and Evaluation
Authors: Openshaw John J , Travassos Mark A 
Published: May 2020

Abstract
There have been several significant outbreaks of COVID-19 in federal immigrant detention centers, which lack clear and consistent guidelines across Department of Homeland Security (DHS) agencies to limit the spread of COVID-19. The Centers for Disease Control and Prevention (CDC) has issued detailed guidelines for the control, prevention, and evaluation of COVID-19 in detention facilities. Although the DHS’s Immigration and Customs Enforcement agency has stated that it complies with CDC recommendations, its policies significantly differ from these CDC guidelines, placing detainees at risk for contracting COVID-19. This submission urges the adoption of CDC guidelines across DHS-associated facilities. Such a policy change has the potential to protect and save the lives of the most vulnerable populations under the auspices of the federal government.
SkySlide: A Hybrid Method for Landslide Susceptibility Assessment based on Landslide-Occurring Data Only
Authors: Mutlu Alev , Goz Furkan 
Published: May 2020

Abstract
Landslide susceptibility assessment is the problem of determining the likelihood of a landslide occurrence in a particular area with respect to the geographical and morphological properties of the area. This paper presents a hybrid method, namely SkySlide, that incorporates clustering, skyline operator, classification and majority voting principle for region-scale landslide susceptibility assessment. Clustering and skyline operator are utilized to model landslides while classification and majority voting principle are utilized to assess landslide susceptibility. The contribution of the study is 2-fold. First, the proposed method requires properties of landslide-occurring data only to model landslides. Second, the proposed method is evaluated on imbalanced data and experimental results include performance metrics of imbalanced data. Experiments conducted on two real-life datasets show that clustering greatly improves performance of SkySlide. Experiments further demonstrate that SkySlide achieves higher class balance accuracy, Matthews correlation coefficient, geometric mean and bookmaker informedness scores compared with the most commonly used methods for landslide susceptibility assessment such as support vector machines, logistic regression and decision trees.
Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial
Authors: Tuñón José , Steg Philippe Gabriel , Bhatt Deepak L , Bittner Vera A , Díaz Rafael , Goodman Shaun G , Jukema J Wouter , Kim Yong-Un , Li Qian H , Mueller Christian , Parkhomenko Alexander , Pordy Robert , Sritara Piyamitr , Szarek Michael , White Harvey D , Zeiher Andreas M , Schwartz Gregory G ,   for the ODYSSEY OUTCOMES Investigators
Published: May 2020

Abstract

Aims
Statins reduce cardiovascular risk in patients with acute coronary syndrome (ACS) and normal-to-moderately impaired renal function. It is not known whether proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors provide similar benefit across a range of renal function. We determined whether effects of the PCSK9 inhibitor alirocumab to reduce cardiovascular events and death after ACS are influenced by renal function.

Methods and results
ODYSSEY OUTCOMES compared alirocumab with placebo in patients with recent ACS and dyslipidaemia despite intensive statin treatment. Estimated glomerular filtration rate (eGFR) &lt;30 mL/min/1.73 m2 was exclusionary. In 18 918 patients, baseline eGFR was 82.8 ± 17.6 mL/min/1.73 m2, and low-density lipoprotein cholesterol (LDL-C) was 92 ± 31 mg/dL. At 36 months, alirocumab decreased LDL-C by 48.5% vs. placebo but did not affect eGFR (P = 0.65). Overall, alirocumab reduced risk of the primary outcome (coronary heart disease death, non-fatal myocardial infarction, ischaemic stroke, or unstable angina requiring hospitalization) with fewer deaths. There was no interaction between continuous eGFR and treatment on the primary outcome or death (P = 0.14 and 0.59, respectively). Alirocumab reduced primary outcomes in patients with eGFR ≥90 mL/min/1.73 m2 (n = 7470; hazard ratio 0.784, 95% confidence interval 0.670–0.919; P = 0.003) and 60 to &lt;90 (n = 9326; 0.833, 0.731–0.949; P = 0.006), but not in those with eGFR &lt; 60 (n = 2122; 0.974, 0.805–1.178; P = 0.784). Adverse events other than local injection-site reactions were similar in both groups across all categories of eGFR.

Conclusions
In patients with recent ACS, alirocumab was associated with fewer cardiovascular events and deaths across the range of renal function studied, with larger relative risk reductions in those with eGFR &gt; 60 mL/min/1.73 m2.
Current challenges and future opportunities of phage therapy
Authors: Pires Diana P , Costa Ana Rita , Pinto Graça , Meneses Luciana , Azeredo Joana 
Published: May 2020

ABSTRACT
Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.
Spatial relationship between shallow very low frequency earthquakes and the subducted Kyushu-Palau Ridge in the Hyuga-nada region of the Nankai subduction zone
Authors: Tonegawa Takashi , Yamashita Yusuke , Takahashi Tsutomu , Shinohara Masanao , Ishihara Yasushi , Kodaira Shuichi , Kaneda Yoshiyuki 
Published: May 2020

SUMMARYShallow very low frequency earthquakes (sVLFEs) have occurred recurrently at the shallow plate interface of the Hyuga-nada region of the western Nankai subduction zone, Japan. Although the locations of sVLFE epicentres have been determined using land-based seismic records with moderate accuracy, it is necessary to determine their locations more precisely to explore the relationship between sVLFEs and other shallow slow earthquakes and examine the structural factors that may control sVLFE activity. Here, we identified sVLFE epicentres using seismic records obtained from temporarily deployed ocean bottom seismometers (OBSs) in the Hyuga-nada region. Seismic observations involved the deployment of 5–13 OBSs for approximately 1 yr, with deployments conducted three times during 2014–2016 each time with changing OBS numbers and array distribution. As a result, one sVLFE episode, containing successive Rayleigh wave pulses with slow velocities due to marine sediments, could be detected at a frequency band of 0.1–0.15 Hz per observation, resulting in a total of three episodes. Rayleigh wave amplitudes of ordinary earthquakes in the continuous records were suppressed using earthquake catalogues. We estimated the dispersion curve for the Rayleigh wave group velocity for each array, which represented the averaged group velocity within the array, using coda interferometry, and applied an envelope correlation method (ECM) using the group velocities to continuous records. These processing provided sVLFE epicentres with horizontal distance errors of &lt;5 km. Our results showed that sVLFEs depths, which were inferred from the contour line of the top of the Phillipine Sea Plate, had increased from &lt;10 km to 10–15 km in the region of the subducted Kyusyu-Palau Ridge (KPR). It was also apparent that migration of sVLFE epicentres occurred in 2015 from a depth of 15 km to shallower depths along the northern margin of the subducted KPR. These results identified the subducted KPR as a structural factor controlling the excitation conditions of sVLFE activities.
Separation of tectonic and local components of horizontal GPS station velocities: a case study for glacial isostatic adjustment in East Antarctica
Authors: Turner Ross J , Reading Anya M , King Matt A 
Published: May 2020

SUMMARY
Accurate measurement of the local component of geodetic motion at GPS stations presents a challenge due to the need to separate this signal from the tectonic plate rotation. A pressing example is the observation of glacial isostatic adjustment (GIA) which constrains the Earth’s response to ice unloading, and hence, contributions of ice-covered regions such as Antarctica to global sea level rise following ice mass loss. While both vertical and horizontal motions are of interest in general, we focus on horizontal GPS velocities which typically contain a large component of plate rotation and a smaller local component primarily relating to GIA. Incomplete separation of these components introduces significant bias into estimates of GIA motion vectors. We present the results of a series of tests based on the motions of GPS stations from East Antarctica: (1) signal separation for sets of synthetic data that replicate the geometric character of non-separable, and separable, GIA-like horizontal velocities; and (2) signal separation for real GPS station data with an appraisal of uncertainties. For both synthetic and real motions, we compare results where the stations are unweighted, and where each station is areal-weighted using a metric representing the inverse of the spatial density of neighbouring stations. From the synthetic tests, we show that a GIA-like signal is recoverable from the plate rotation signal providing it has geometric variability across East Antarctica. We also show that areal-weighting has a very significant effect on the ability to recover a GIA-like signal with geometric variability, and hence on separating the plate rotation and local components. For the real data, assuming a rigid Antarctic plate, fitted plate rotation parameters compare well with other studies in the literature. We find that 25 out of 36 GPS stations examined in East Antarctica have non-zero local horizontal velocities, at the 2σ level, after signal separation. We make the code for weighted signal separation available to assist in the consistent appraisal of separated signals, and the comparison of likely uncertainty bounds, for future studies.
Magnetotelluric imaging of the Mérida Andes and surrounding areas in Venezuela
Authors: Cruces-Zabala J , Ritter O , Weckmann U , Tietze K , Schmitz M 
Published: May 2020

SUMMARYThe Caribbean and South American tectonic plates bound the north-eastwards expulsion of the North Andean Block in western Venezuela. This complex geodynamic setting resulted in the formation of major strike-slip fault systems and sizeable mountain chains. The 100-km-wide Mérida Andes extend from the Colombian/Venezuelan border to the Caribbean coast. To the north and south, the Mérida Andes are bound by hydrocarbon-rich sedimentary basins. Knowledge of lithospheric structures, related to the formation of the Mérida Andes, is limited though, due to a lack of deep geophysical data. In this study, we present results of the first broad-band magnetotelluric profile crossing the Mérida Andes and the Maracaibo and Barinas–Apure foreland basins on a length of 240 km. Geoelectrical strike and dimensionality analysis are consistent with 1-D or 2-D subsurface structures for the sedimentary basins but also indicate a strong 3-D setting for the Mérida Andes. Using a combination of 2-D and 3-D modelling we systematically examined the influence of 3-D structures on 2-D inversions. Synthetic data sets derived from 3-D modelling allow identification and quantification of spurious off-profile features as well as smoothing artefact due to limited areal station coverage of data collected along a profile. The 2-D inversion models show electrically conductive basins with depths of 2–5 km for the Barinas-Apure and 2–7 km for the Maracaibo basins. A number of resistive bodies within the Maracaibo basin could be related to active deformation causing juxtaposition of older geological formations and younger basin sediments. The most important fault systems of the area, the Boconó and Valera Faults, cross-cut the Mérida Andes in NE–SW direction along its strike on a length 400 km and N–S direction at its centre on a length 60 km, respectively. Both faults are associated with subvertical zones of high electrical conductivity and sensitivity tests suggest that they reach depths of up to 12 km. A sizeable conductor at 50 km depth, which appears consistently in the 2-D sections, could be identified as an inversion artefact caused by a conductor east of the profile. We speculate the high conductivity associated with the off-profile conductor may be related to the detachment of the Trujillo Block. Our results partially support the ‘floating orogen hypothesis’ developed to explain the geodynamic evolution of western Venezuela and they highlight the relevance of the Trujillo Block in this process.
Dissecting genome-wide studies for microbiome-related metabolic diseases
Authors: Awany Denis , Allali Imane , Chimusa Emile R 
Published: May 2020

Abstract
Despite the meteoric rise in genome-wide association studies for metabolic diseases (MetD) over the last few years, our understanding of the pathogenesis of these diseases is still far from complete. Recent developments have established that MetD arises from complex interactions between host genetics, the gut microbiome and the environment. However, our knowledge of the genetic and microbiome components involved and the underlying molecular mechanisms remains limited. Here, we review and summarize recent studies investigating the genetic and microbiome basis of MetD. Then, given the critical importance of study-individual’s ancestry in these studies, we leverage 4932 whole-genome sequence samples from 18 worldwide ethnic groups to examine genetic diversity in currently reported variants associated with MetD. The analyses show marked differences in gene-specific proportion of pathogenic single-nucleotide polymorphisms (SNPs) and gene-specific SNPs MAFs across ethnic groups, highlighting the importance of population- and ethnic-specific investigations in pinpointing the causative factors for MetD. We conclude with a discussion of research areas where further investigation on interactions between host genetics, microbiome and the environment is needed.
Catch-up dynamics in early industry lifecycle stages—a typology and comparative case studies in four clean-tech industries
Authors: Binz Christian , Gosens Jorrit , Yap Xiao-Shan , Yu Zhen 
Published: May 2020

Abstract
The literature on catch-up cycles has not yet systematically conceptualized how catch-up dynamics differ between the various industries that are emerging in the green techno-economic paradigm. We address this gap by connecting catch-up cycle theory with an industry typology from global innovation systems (GISs) literature, which distinguishes four generic industry types with footloose, spatially sticky, market-, and production-anchored innovation system characteristics. Catch-up patterns in early industry lifecycle stages are expected to systematically differ between these four industry types. This assumption is explored based on a comparative case study of the solar photovoltaics, wind power, solar water heaters, and membrane bioreactors industries, each of which exemplifies one of the four generic GIS configurations. We find that the speed and disruptiveness of early leadership changes differ significantly between the four industries, and that the effectiveness of capability upgrading strategies and catching-up policies are contingent on the innovation and valuation characteristics of each industry’s underlying GIS type.
McShane-Type Identities for Quasifuchsian Representations of Nonorientable Surfaces
Authors: Huang Yi 
Published: May 2020

Abstract
We show that Norbury’s McShane identity for nonorientable cusped hyperbolic surfaces $N$ generalizes to quasifuchsian representations of $\pi _1(N)$ as well as pseudo-Anosov mapping Klein bottles with singular fibers given by $N$.
A public health concern: emergence of carbapenem-resistant Klebsiella pneumoniae in a public transportation environment
Authors: Cao Tingting , Liu Yuanyuan , Li Yiming , Wang Yang , Shen Zhangqi , Shao Bin , Walsh Timothy R , Shen Jianzhong , Wang Shaolin 
Published: May 2020

AbstractObjectivesThis study was designed to understand the prevalence of antibiotic-resistant bacteria in the Beijing subway environment and the potential transmission of carbapenem-resistant Enterobacteriaceae in a public transportation environment.MethodsCarbapenem-resistant isolates were selected on brain heart infusion agar supplemented with meropenem (0.5 mg/L) and antimicrobial susceptibility testing was conducted using the broth microdilution method. WGS analyses were conducted for 11 Klebsiella pneumoniae isolates to identify resistance genes. The genetic relationships among the isolates were evaluated by MLST and PFGE.ResultsWe identified 11 carbapenem-resistant K. pneumoniae isolates from the Beijing subway environment. WGS revealed three STs among the 11 isolates, with 9 isolates classified as ST726 and containing a blaNDM-5-carrying IncX3 plasmid. The genetic environment of blaNDM-5 was very similar to that observed in other blaNDM-5-containing clinical isolates.ConclusionsThe presence of carbapenem-resistant Enterobacteriaceae in a public transportation environment is concerning and indicates that regular antimicrobial resistance surveillance is urgent and necessary.