bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Team Familiarity: An Integrative Review
Authors: Stucky Christopher H. , De Jong Marla J. 
Published: December 2020

ABSTRACTThe dynamic nature of perioperative care often brings unfamiliar clinicians together yet requires them to collectively provide complex health care in a challenging environment. In this review, we comprehensively evaluated evidence regarding surgical team familiarity and its relationship to surgical team performance. Using a comprehensive and iterative search strategy, we searched PubMed, Web of Science, PsycInfo, and EMBASE for surgical team familiarity manuscripts. We identified 598 manuscripts, 16 of which met our inclusion criteria. We found that surgical team familiarity is associated with improved performance for many metrics, including shorter total operative time, team member safety, decreased surgical errors and disruptions, reduced miscommunication, and fewer patient readmissions. Although additional research would be helpful, surgical managers should consider team familiarity and consistency in team membership when assigning staff members to surgical teams to optimize surgical care, decrease inefficiencies, and promote safe patient outcomes.
Understanding information: Adding a non‐individualistic lens
Authors: Ma Yuanye 
Published: December 2020

AbstractThe individualistic lens refers to the understanding of problematic information as something that is clearly identifiable, with objective criteria of measurement. This article argues for adding a non‐individualistic lens for understanding information. The necessity for adding a non‐individualistic lens grows from that the existing individualistic lens appears inadequate to make sense of information phenomenon, in particular when it comes to understanding problematic information. Non‐individualistic is proposed as a complementary perspective, which needs to be further developed conceptually. To begin such development, this article directs information professionals' attention to the promising concept of information ecology. More specifically, this article pulls resources from philosophy of information (Floridi's infosphere) and information ethics (Capurro's Angeletics) to illustrate existing conceptualizations of information ecology. Information ecology appears to align with this sociotechnical view that information researchers have started to develop in the most recent years, though arguably information ecology may have an even broader scope. Lastly, this article also points out that the conceptualization of information ecology needs to be aware of, and cautious of the philosophical assumption that is relied on for understanding information.
Polyester‐ZrO2 Nanocomposite Electrolytes with High Li Transference Numbers for Ambient Temperature All‐Solid‐State Lithium Batteries
Authors: Lee Tian Khoon , Andersson Rassmus , Dzulkurnain Nurul Akmaliah , Hernández Guiomar , Mindemark Jonas , Brandell Daniel 
Published: December 2020

AbstractPolyester‐ and polycarbonate‐based polymer electrolytes have attracted great interest after displaying promising functionality for solid‐state Li batteries. In this present work, poly(ϵ‐caprolactone‐co‐trimethylene carbonate) electrolytes are further developed by the inclusion of ZrO2 particles, prepared by an in situ sol‐gel method. SEM micrographs show that the ZrO2 particles are uniform and 30–50 nm in size. Contrary to many studies on filler‐polymer electrolytes, the changes in ionic conductivity are less significant upon addition of zirconia filler to the polymer electrolyte, but remain at ∼10−5 S cm−1 at room temperature. This can be explained by the amorphous nature of the polymer. Instead, high lithium transference numbers (0.83–0.87) were obtained. Plating/stripping tests with Li metal electrodes show long‐term cycling performance for >1000 cycles at 0.2 mA cm−2. Promising solid‐state lithium battery cycling results at ambient temperature using the material are also shown.
Rhubarb anthraquinone glycosides protect against cerebral ischemia‐reperfusion injury in rats by regulating brain–gut neurotransmitters
Authors: Guo Ying , Li Qiuying , Yu Xiahui , Liang Yuhua 
Published: December 2020

AbstractRhubarb anthraquinone glycosides (RAGs) have been proven to have significant therapeutic effects on ischemic stroke, and this effect may be related to the microbiome–gut–brain axis. In this study, an HPLC‐FLD method was established to measure brain–gut neurotransmitters of rats with cerebral ischemia‐reperfusion injury (CIRI), to explore whether the mechanism of RAGs against CIRI is related to the microbiome–gut–brain axis. A Shimadzu ODS‐3 C18 column was used for chromatographic separation, and 5‐hydroxytryptamine (5‐HT), 5‐hydroxy indole acetic acid (5‐HIAA), glutamic acid (Glu), aspartic acid (Asp), and γ‐aminobutyric acid (GABA) were determined simultaneously. The results showed that there is an excellent linear relationship (R2≥ 0.9990) and a high separation degree in the HPLC‐FLD method. Whereas the contents of Asp and Glu in the brain and colon increased (p < 0.05), the contents of 5‐HT, 5‐HIAA, and GABA in the brain and colon decreased (p < 0.05) after CIRI. RAGs could effectively reduce the contents of Asp and Glu (p < 0.05), and increase the contents of 5‐HT, 5‐HIAA, and GABA in the brain and colon (p < 0.05). Combined with the previous experimental results, we can speculate that RAGs can regulate intestinal flora disorder caused by CIRI, and then regulate the imbalance between the release and decomposition of neurotransmitters caused by intestinal flora disorder.
Safety risk management for low molecular weight process‐related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential
Authors: Luo Haibin , Li Yuling , Robbins David , Wang Sheau‐Chiann , Xi Guoling , Cox Matthew , Nicholson Simone M. , Wei Chenghong , Pabst Timothy M. , Wang William K. 
Published: December 2020

AbstractProcess‐related impurities (PRIs) derived from manufacturing process should be minimized in final drug product. ICH Q3A provides a regulatory road map for PRIs but excludes biologic drugs like monoclonal antibodies (mAbs) that contain biological PRIs (e.g. host cell proteins and DNA) and low molecular weight (LMW) PRIs (e.g., fermentation media components and downstream chemical reagents). Risks from the former PRIs are typically addressed by routine tests to meet regulatory expectations, while a similar routine‐testing strategy is unrealistic and unnecessary for LMW PRIs, and thus a risk‐assessment‐guided testing strategy is often utilized. In this report, we discuss a safety risk management strategy including categorization, risk assessment, testing strategy, and its integrations with other CMC development activities, as well as downstream clearance potentials. The clearance data from 28 mAbs successfully addressed safety concerns but did not fully reveal the process clearance potentials. Therefore, we carried out studies with 13 commonly seen LMW PRIs in a typical downstream process for mAbs. Generally, Protein A chromatography and cation exchange chromatography operating in bind‐and‐elute mode showed excellent clearances with greater than 1,000‐ and 100‐fold clearance, respectively. The diafiltration step had better clearance (greater than 100‐fold) for the positively and neutrally charged LMW PRIs than for the negatively charged or hydrophobic PRIs. We propose that a typical mAb downstream process provides an overall clearance of 5,000‐fold. Additionally, the determined sieving coefficients will facilitate diafiltration process development. This report helps establish effective safety risk management and downstream process design with robust clearance for LMW PRIs.
Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy
Authors: Wang Yiping , Chen Huiqiao , Sun Chenliang , Shen Haoliang , Cui Xiaoli 
Published: December 2020

AbstractAcute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown to be an effective anti‐inflammatory agent in ALI. However, the mechanism of this regulation still remains poorly understood. In our study, we found that epithelial cell senescence was elevated after lipopolysaccharide (LPS) exposure in vivo and in vitro, accompanied by decreased expression of ATG5 and impaired autophagy activity. To further discover the molecular regulation mechanism between cellular senescence and autophagy in LPS‐treated MLE‐12 cells, we demonstrated that inhibition of ATG5 could decrease autophagy levels and promote the senescence of MLE‐12 cells. On the contrary, elevating the expression of ATG5 could effectively suppress LPS‐induced cellular senescence via enhancing autophagy activity. In addition, we demonstrated that metformin could protect MLE‐12 cells from LPS‐induced senescence via increasing the expression of ATG5 and augmenting autophagy activity. Our data implicate that activation of autophagy by metformin may provide a preventive and therapeutic strategy for ALI.
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling
Authors: Liao Wanqin , Fan Lixia , Li Mingchan , Deng Huizhi , Yang Anping , Liu Fang 
Published: December 2020

AbstractMetastasis is a major cause of breast cancer death. MPP7 is a cell polarity controller highly linked to cell migration; however, the function of MPP7 in breast cancer remains unknown. In this study, we reported that MPP7 expression was upregulated in breast cancer tissues and high MPP7 expression predicted poor survival in patients with breast cancer. Ectopic expression of MPP7 markedly enhanced the migration and invasion in breast cancer cells. In contrast, depletion of MPP7 resulted in impaired cell mobility and metastasis. Moreover, we demonstrated that MPP7 exerted its promotional effect via modulation of EMT and activation of the EGFR/AKT cascade. Our study reveals an oncogenic role of MPP7 in breast cancer and suggests that MPP7 may serve as a potential target for exploring novel therapeutic strategies against breast cancer metastasis.
C1q/TNF‐related protein‐9 is elevated in hypertension and associated with the occurrence of hypertension‐related atherogenesis
Authors: Zhou Qi , Cheng Wenli , Wang Zuoguang , Liu Jielin , Han Jing , Wen Shaojun , Liu Jinghua 
Published: December 2020

AbstractC1q‐tumor necrosis factor‐related protein‐9 (CTRP9) is an important adipocytokine that is closely associated with cardiovascular disease. This study aimed to detect CTRP9 expression in hypertensive patients and mice and to analyze its effects on hypertension‐related atherogenesis. First, circulating CTRP9 levels were detected in both nonhypertensive subjects and hypertensive patients. The results showed that plasma CTRP9 levels were increased in hypertension patients compared with control subjects and gradually elevated in the Grade I, Grade II, and Grade III groups. While nondipper state did not affect CTRP9 expression in hypertension patients. Hypertension patients with carotid atherosclerotic plaque (CAP) exhibited higher CTRP9 levels and the high CTRP9 group exhibited significantly higher CAP morbidity, CTRP9 levels were positively correlated with the occurrence of CAP. Then, effects of CTRP9 on angiotensin II (Ang II)‐induced endothelial dysfunction were analyzed in vitro, and the results exhibited that treatment with Ang II significantly increased CTRP9 mRNA expression in endothelial cells (ECs), and downregulation of CTRP9 expression aggravated Ang II‐induced endothelial dysfunction in ECs. Mice were infused with Ang II, and CTRP9 was also increased in Ang II‐infused mice and mainly secreted by ECs. In Ang II‐infused ApoE−/− mice, treatment with recombinant CTRP9 significantly reduced atherosclerotic area and alleviated endothelial dysfunction. In conclusion, our results may found that CTRP9 delayed the progression of hypertension‐related arteriosclerosis by alleviating endothelial dysfunction.
Identifying ataxia‐telangiectasia in cancer patients: Novel insights from an interesting case and review of literature
Authors: Cao Jinyi , Tan Ryan Ying Cong , Li Shao‐Tzu , Courtney Eliza , Goh Ronald Chin Hong , Fan Bingwen Eugene , Sommat Kiattisa , Nadarajah Ravichandran , Ngeow Joanne 
Published: December 2020

AbstractTimely genetic testing leading to early diagnosis of A‐T is crucial due to its plethora of implications on clinical management, particularly in those who develop malignancies. Thus, clinicians have to be astute in identifying diagnostic clues of A‐T.
Do Sulfonamides Interact with Aromatic Rings?
Authors: Jian Jie , Hammink Roel , McKenzie Christine J. , Bickelhaupt F. Matthias , Poater Jordi , Mecinović Jasmin 
Published: December 2020

AbstractAromatic rings form energetically favorable interactions with many polar groups in chemical and biological systems. Recent molecular studies have shown that sulfonamides can chelate metal ions and form hydrogen bonds, however, it is presently not established whether the polar sulfonamide functionality also interacts with aromatic rings. Here, synthetic, spectroscopic, structural, and quantum chemical analyses on 2,6‐diarylbenzenesulfonamides are reported, in which two flanking aromatic rings are positioned close to the central sulfonamide moiety. Fine‐tuning the aromatic character by substituents on the flanking rings leads to linear trends in acidity and proton affinity of sulfonamides. This physical‐organic chemistry study demonstrates that aromatic rings have a capacity to stabilize sulfonamides via through‐space NH–π interactions. These results have implications in rational drug design targeting electron‐rich aromatic rings in proteins.
Liquid‐Like Phase of N,N‐Dimethylpyrrolidinium Iodide Impregnated into COFs Endows Fast Lithium Ion Conduction in the Solid State
Authors: Wu Zhenzhen , Xu Qinchao , Li Juan , Zhang Xian‐Ming 
Published: December 2020

AbstractA novel kind of solid‐state lithium electrolyte was fabricated by impregnating organic ionic plastic crystals (OIPCs) into the pores of covalent organic frameworks (COFs). The liquid‐like phase of confined N,N‐dimethylpyrrolidinium iodide (P1,1I) and the ordered nanochannels of COFs simultaneously stimulated the lithium ion conduction.
Rhodium(I)‐Catalyzed Three‐Component [4+2+1] Cycloaddition of Two Vinylallenes and CO
Authors: Cui Qi , Tian Zi‐You , Yu Zhi‐Xiang 
Published: December 2020

AbstractTransition metal‐catalyzed [4+2+1] reactions of dienes (or diene derivatives such as vinylallenes), alkynes/alkenes, and CO (or carbenes) are expected to be the most straightforward approach to synthesize challenging seven‐membered ring compounds, but so far only limited successes have been realized. Here, an unexpected three‐component [4+2+1] reaction between two vinylallenes and CO was discovered to give highly functionalized tropone derivatives under mild conditions, where one vinylallene acts as a C4 synthon, the other vinylallene as a C2 synthon, and CO as a C1 synthon. It was proposed that this reaction occurred via oxidative cyclization of the diene part of one vinylallene molecule, followed by insertion of the terminal alkene part of the allene moiety in another vinylallene, into the Rh−C bond of five‐membered rhodacycle. Then, CO insertion and reductive elimination gave the [4+2+1] cycloadduct. Further experimental exploration of why ene/yne‐vinylallenes and CO gave monocyclic tropone derivatives instead of 6/7‐bicyclic ring products were reported here.
Impact of Chimney‐draught Conditions on Combustion and Emission Behavior of a Wood‐burning Stove
Authors: Endriss Felix , Grammer Peter , Russ Michael , Thorwarth Harald 
Published: December 2020

AbstractPollutants from combustion in wood‐burning stoves are influenced by many factors, including the exhaust gas system. This is responsible for the air supply due to the draught generated. Contrary to results reported in literature the experiments in this study show no effect on temperature related to increasing air supply and a total dust decreasing at higher draughts. The results also show no significant impact of the draught on gaseous emissions (CO/OGC/NOx). The most significant loss was determined at thermal efficiency, which lost up to 13 % absolute with increasing draught.
Systemic inflammation and symptomatology in patients with prostate cancer treated with androgen deprivation therapy: Preliminary findings
Authors: Hoogland Aasha I. , Jim Heather S. L. , Gonzalez Brian D. , Small Brent J. , Gilvary Danielle , Breen Elizabeth C. , Bower Julienne E. , Fishman Mayer , Zachariah Babu , Jacobsen Paul B. 
Published: December 2020

BackgroundIncreases in fatigue, depressive symptomatology, and cognitive impairment are common after the initiation of androgen deprivation therapy (ADT) for prostate cancer. To date, no studies have examined the potential role of inflammation in the development of these symptoms in ADT recipients. The goal of the current study was to examine circulating markers of inflammation as potential mediators of change in fatigue, depressive symptomatology, and cognitive impairment related to the receipt of ADT.MethodsPatients treated with ADT for prostate cancer (ADT+; n = 47) were assessed around the time of the initiation of ADT and 6 and 12 months later. An age‐ and education‐matched group of men without a history of cancer (CA–; n = 82) was assessed at comparable time points. Fatigue, depressive symptomatology, and cognitive impairment were assessed with the Fatigue Symptom Inventory, the Center for Epidemiological Studies Depression Scale, and a battery of neuropsychological tests, respectively. Circulating markers of inflammation included interleukin 1 receptor antagonist (IL‐1RA), interleukin 6 (IL‐6), soluble tumor necrosis factor receptor II (sTNF‐RII), and C‐reactive protein (CRP).ResultsFatigue, depressive symptomatology, and serum IL‐6 increased significantly over time in the ADT+ group versus the CA– group; rates of cognitive impairment also changed significantly between the groups. No significant changes in IL‐1RA, sTNF‐RII, or CRP over time were detected. Treatment‐related increases in IL‐6 were associated with worsening fatigue but not depressive symptomatology or cognitive impairment.ConclusionsResults of this preliminary study suggest that increases in circulating IL‐6, perhaps due to testosterone inhibition, may play a role in fatigue secondary to receipt of ADT. Additional research is needed to determine whether interventions to reduce circulating inflammation improve fatigue in this population.
Visible‐Light Absorbing TiO2 : Curcumin Thin Films with ALD/MLD
Authors: Philip Anish , Ghiyasi Ramin , Karppinen Maarit 
Published: December 2020

AbstractCurcumin is known for its antimicrobial effects. Here we use the atomic/molecular layer deposition (ALD/MLD) thin‐film technique to embed monomolecular curcumin layers within a photocatalytic TiO2 matrix into different superlattice structures with the anticipation of intriguing synergistic effects. We demonstrate the extension of the light absorption to the entire visible range which could pave the way for the use of these films for light‐driven destruction of pathogens.
Phase 1 Study of the Effects of the Tuberculosis Treatment Pretomanid, Alone and in Combination With Moxifloxacin, on the QTc Interval in Healthy Volunteers
Authors: Li Mengchun , Saviolakis George A. , El‐Amin Wael , Makhene Mamodikoe K. , Osborn Blaire , Nedelman Jerry , Yang Tian J. , Everitt Daniel 
Published: December 2020

AbstractTuberculosis (TB) continues to be a serious threat to public health throughout the world. Newer treatments are needed that could offer simplified regimens with activity against both drug‐sensitive and drug‐resistant bacilli, while optimizing safety. Pretomanid (PA‐824), a nitroimidazooxazine compound, is a new drug for the treatment of pulmonary TB that was recently approved in the United States and Europe in the context of a regimen combined with bedaquiline and linezolid. This phase 1 double‐blind, randomized, placebo‐controlled crossover study specifically examined the effect of single‐dose administration of pretomanid 400 or 1000 mg and pretomanid 400 mg plus moxifloxacin 400 mg on the QTc interval in 74 healthy subjects. Subjects were fasting at the time of drug administration. Pretomanid concentrations following single 400‐ or 1000‐mg doses were not associated with any QT interval prolongation of clinical concern. Moxifloxacin did not alter the pharmacokinetics of pretomanid, and the effect of pretomanid 400 mg plus moxifloxacin 400 mg on the individually corrected QT interval was consistent with the effect of moxifloxacin alone. Both drugs were generally well tolerated. Although supratherapeutic exposure of pretomanid relative to the now‐recommended dosing with food was not achieved, these findings contribute to the favorable assessment of cardiac safety for pretomanid.
Metal‐Binding Foldamers
Authors: Rao Shilpa R. , Schettler Shelby L. , Horne W. Seth 
Published: December 2020

AbstractSequence‐defined oligomeric molecules with discrete folding propensities, termed foldamers, are a versatile source of agents with tailored structure and function. An inspiration for the development of the foldamer paradigm are natural biomacromolecules, the sequence‐encoded folding of which is the basis of life. Metal ions and clusters are common features in proteins, where the role of metal varies from supporting structure to enabling function. The ubiquity of metals in natural systems suggests promise for metals in the context of folded artificial backbones. In this Minireview, we highlight efforts to realize this potential through a survey of published work on the design, synthesis, and characterization of metal‐binding foldamers.
Theoretical and Experimental Insights into the Self‐Assembly and Ion Response Mechanisms of Tripodal Quinolinamido‐Based Supramolecular Organogels
Authors: Li Zhao‐Hui , Yang Hai‐Long , Adam Khalid Mohammed , Yao Hong , Wei Tai‐Bao , Zhang You‐Ming , Lin Qi 
Published: December 2020

AbstractThe exploration and understanding of self‐assembly and stimuli‐responsive mechanisms of supramolecular systems are of fundamental importance for researchers to plan syntheses reasonably. Herein, the self‐assembly and ions responsive mechanisms of a tripodal quinolinamido‐based supramolecular organogel (TBT‐gel) were investigated through experiments and theoretical calculations including independent gradient model (IGM), localized orbitals locator (LOL) and hole‐electron theory. According to these studies, the self‐assembly mechanism of TBT‐gel was based on strong threefold H‐bonding and π–π interactions, which induced the TBT forming helical, one‐dimensional supramolecular polymer. After addition of Fe3+ into the TBT‐gel, the one‐dimensional supramolecular polymer had been crosslinked by the Fe3+ through coordination interaction and formed a metallogel (TBT‐Fe‐gel). Interestingly, the TBT‐gel showed selective fluorescent response for Fe3+ and F− based on a competitive coordination mechanism. Moreover, the study on fluorescence responsive mechanism of TBT‐gel for Fe3+ and F− implied the ICT mode governs both the electron excitation and de‐excitation processes. The calculated results were in agreement with the corresponding experimental results. Notably, the quantum chemical calculations provided a deep understanding and visualized presentation of the assembly and stimuli‐responsive mechanisms.