bluuebunny/crossref_metadata_2025_split huggingface dataset:
OPTIMIZATION OF LIQUID CHROMATOGRAPHIC CONDITIONS TO SEPARATE WATER-SOLUBLE VITAMINS
Authors: Ostapiv R. D. , Tkachenko V. І. 
Published: August 2020

Vitamins are widely used in veterinary medicine, in particular, as components of premixes, feeds and feed additives to increase the productivity of farm animals. Most of these feed additives are a complex amino acid and vitamin mixtures (of ten active substances or more) based on the matrix of plant or animal origin, which can be enriched with protein. When the analyst is faced with the difficult task of analyzing such a mixture, it is usually necessary to use several variants of the HPLC method (high-performance liquid chromatography), which increases the time and cost of analysis of the premix or feed additive. The aim of this work was to optimize the validated method of analysis of riboflavin in premixes and feed additives available in the laboratory for simultaneous (during one chromatographic separation) determination of the content of the maximum amount of water-soluble vitamins. A Waters liquid chromatograph equipped with an Alliance 2690 separation module with a PAD 996 diode array detector was used for separation. Water-soluble vitamins were separated on a Luna Omega Polar C18 250 × 4.6 mm, 5 μm chromatographic column. As solvents were used 0.05 M phosphate buffer pH 3.0 and 0.1 M sodium hydroxide solution (for folic acid).
The article describes the stages of liquid chromatographic separation parameters optimization of twelve vitamins and vitamin-like substances (thiamine hydrochloride, riboflavin, flavin mononucleotide phosphate, nicotinic acid, nicotinamide, calcuim pantothenate, phosidinobacino acidorinolobin, hydrocyanide). Chromatograms of standard samples solutions are given, which show the specificity of the technique. Isocratic and gradient elution schemes are investigated. Some parameters of chromatographic peaks under conditions of gradient separation of vitamins are estimated. The parameters of the chromatographic peaks do not exceed the limits recommended in the State Pharmacopoeia of Ukraine (SPU 2.0), that will allow to further carry out a more complete validation of the method for quantitative determination of water-soluble vitamins in various complex matrices: injection and oral solutions, feeds and premixes.
CONCEPT «MARKET» IN ECONOMIC THEORY
Authors: Temnenko S. M. 
Published: August 2020

The essence of the market as an economic category was analyzed in the article. Interpretation of the "market" concept by the classics of economic thought as well as by modern domestic and foreign scientists was considered. The evolution of scientific knowledge regarding the depth of understanding and difference of approaches to the interpretation of this economic category was traced.
The market as an economic phenomenon has emerged as a result of such socio-economic processes as production and exchange. In the process of forming economically independent business entities, there was a transition from direct commodity exchange to more complex economic relations, such as buying and selling. The relationship between sellers and buyers gradually became more complex and multilevel. The concepts of supply and demand appear in economic theory, emerges a basic tenet of economics about the market as the main mechanism for establishing optimal proportions between production and consumption.
Thus, over time, the understanding of the "market" has transformed from a narrow interpretation as a platform where purchase and sale takes place to a complex mechanism that regulates economic relations in the process of production and distribution of resources and public goods.
An analysis of modern publications has shown that modern discourse on the nature of the "market" significantly expands the semantics of this concept. In our opinion, the thesis about the "market" - as a sphere of realization of human freedom, and about the person - as central and most important subject of market, is extremely interesting. In this regard, the age-old controversy of economists over the freedom of the market and the expediency of state intervention in the relationship between sellers and buyers, producers and consumers is gaining new arguments.
Often, modern market definitions are rather cumbersome and difficult to understand, therefore we offer a more concise definition of the market as an economic environment, which serves as a coordinating mechanism where producers, sellers and consumers interact in a competitive environment, and as a result of such interaction a general equilibrium of prices is formed.
Gambaran Risiko Kejadian Carpal Tunnel Syndrome pada Karyawan Administrasi Universitas Kristen Krida Wacana
Authors: Suparto Suparto , Lisandra Vanessa Malise , Tanpomas Irvan , Perangin-angin Citra Rencana 
Published: August 2020

Carpal Tunnel Syndrome (CTS) adalah gangguan saraf pada ekstremitas atas di mana nervus medianus terhimpit. Gangguan ini disebabkan oleh berbagai faktor yang mengakibatkan penyempitan terowongan karpal. Penyebab paling umum adalah pekerjaan engan gerakan mengetik atau fleksi dan ekstensi pergelangan tangan berulang. Penelitian ini dilakukan untuk mengetahui gambaran kejadian CTS pada karyawan administrasi yang menggunakan komputer setiap harinya berdasarkan keluhan utama, usia, jenis kelamin, lama mengetik, masa kerja, posisi pergelangan tangan dan tes phalen. Sampel diperoleh dengan cara purposive sampling. Data penelitian dikumpulkan melalui kuesioner serta tes phalen dan diolah menggunakan program SPSS 23. Hasil penelitian dari 29 responden didapatkan gambaran risiko CTS dengan rentang usia 40-60 tahun sebanyak 11 responden (37,9%) berisiko CTS, 16 responden (55,2%) positif CTS. Karyawan dengan lama bekerja lebih dari 4 jam per hari dan berisiko CTS sebanyak 18 responden (62,1%) dan karyawan dengan masa kerja lebih dari 4 tahun dan berisiko CTS sebanyak 23 responden (79,3%). Sebanyak 16 responden (55,2%) dengan posisi pergelangan tangan janggal berisiko mengalami CTS. Studi menyimpulkan bahwa angka kejadian CTS pada karyawan administrasi meningkat seiring dengan bertambahnya usia, lama bekerja dan posisi pergelangan tangan yang janggal pada saat bekerja. Karena itu, edukasi kepada karyawan administrasi mengenai faktor yang dapat menyebabkan CTS harus dilakukan.
SONORIDADES MICROPOLÍTICAS NA ARTE DE MANATA LAUDARES / Micropolitical sonorities in the art of Manata Laudares
Authors: Fasani Priscilla Porto Nascimento 
Published: August 2020

Este artigo apresenta parte da tese SoundSystem: experiências sonoras e dançantes partilhadas pelos artistas Franz Manata e Saulo Laudares no circuito independente de arte contemporânea. A partir das disparações afetivas incitadas por ThePlace (1998-...), que é a própria pista de dança como obra de arte, Heartbeat(2006), instalação sonora que compartilha uma conversa entre corações e, pela intervenção urbana AFTER:Nature(2008-...), que disponibiliza ao público o canto dos pássaros, pensaremos sobre a posição política assumida pelos artistas, que é realizada através da ativação de um saber eco-etológico.Palavras-chave: Arte sonora; Sound System; Corpo vibrátil; Micropolítica; Manata Laudares.AbstractThis article presents part of the SoundSystem thesis: sound and dancing experiences shared by artists Franz Manata and Saulo Laudares in the independent circuit of contemporary art. Based on the affectives hots triggered by The Place (1998 -...), which is the dance floor itself as a work of art, Heartbeat (2006), a sound installation that shares a conversation between hearts and, through urban intervention AFTER: Nature ( 2008 -...), which makes the song of birds available to the public, we will think about the political position assumed by the artists, which is accomplished through the activation of an eco-ethological knowledge.Keywords: Sound art; Sound System; Vibrating body; Micropolitics; Manata Laudares.
GRANDE ORLÂNDIA: UMA MANIFESTA ABAIXO DA LINHA VERMELHA / Grande Orlândia: a manifest underneath Red Line (Linha Vermelha)
Authors: Eilers Helena Wilhelm 
Published: August 2020

Na virada dos anos 1990 para os anos 2000 uma série de proposições pensadas e executadas pelos próprios artistas se difunde no Rio de Janeiro. O presente artigo busca trazer a história de Grande Orlândia – Artistas Abaixo da Linha Vermelha (2003), exposição sem patrocínio, fora do circuito de museus e galerias e que reuniu mais de 100 artistas, numa mistura de exposição, festa e manifestação política. No texto a Grande Orlândia é narrada, principalmente, a partir do olhar de alguns dos artistas participantes. É evidenciado não apenas a força do circuito independente, como os deslocamentos e pontos de contato junto ao território institucional.Palavras-chave: Arte contemporânea; Exposições; Circuito independente; Micropolítica.AbstractAt the turn of the 1990s to the 2000s, a series of propositions thought and produced by the artists themselves spread in Rio de Janeiro. This article brings the history of Grande Orlândia – artistas abaixo da Linha Vermelha (2003), an exhibition without sponsorship, outside the circuit of museums and galleries that brought together more than 100 artists. A mixture of exhibition, party and political manifestation. In the text, Grande Orlândia is narrated, mainly, from the perspective of some of the participating artists. Is evidented not only the strength of the independent circuit, but also the displacements and contact points within the institutional territory.Keywords: Contemporary art; Exhibitions; Independent circuit; Micropolitics.
TUDO PODE SER ARTE, MAS ARTE NÃO PODE (SER) TUDO / Everything can be art but art cannot be everything
Authors: Lopes Fernanda 
Published: August 2020

Reedição de entrevista realizada com o artista visual Milton Machado, publicada na DARDO Magazine, Santiago de Compostela, EP, n. 26, p. 78-97, 2015.
THE MAPPING JOURNEY PROJECT DE BOUCHRA KHALILI: FAZENDO MAPAS FALAREM / The Mapping Journey Project by Bouchra Khalili: making maps speak
Authors: Silva Valdir Pierote 
Published: August 2020

A partir da obra The Mapping Journey Project de Bouchara Khalili, este artigo aborda as tensões entre o sistema de codificação geopolítica contemporâneo e a mobilidade de populações marcadas como indesejáveis, especificamente imigrantes e refugiados que tentam ingressar na Europa. Para acessar esses tensionamentos, o artigo produz uma espécie de contracartografia ao transitar por algumas linhas de força que estabelecem fronteiras, instituem mapas oficiais e compartimentalizam o mundo, separando populações que importam daquelas que supostamente não possuem valor.Palavras-chave: Arte e migração; Arte contemporânea africana; Mapas; Fronteiras; Deslocamentos humanos.AbstractBased on Bouchara Khalili's The Mapping Journey Project, this article addresses the tensions between the contemporary geopolitical coding system and the mobility of populations marked as undesirable, specifically immigrants and refugees trying to enter Europe. In order to access these tensions, the article produces a kind of counter-cartography when passing through some lines of force that establish borders, establish official maps and compartmentalize the world, separating populations that matter from those that are supposed to be worthless.Keywords: Art and migration; African contemporary art; Maps; Borders; Human displacements.
VIOLÊNCIA, CORPO E IMAGEM: NUNO RAMOS E ROSANGELA RENNÓ / Violence, body and image: Nuno Ramos and Rosangela Rennó
Authors: Rodrigues Tadeu Ribeiro 
Published: August 2020

O presente artigo busca explorar relações entre violência, corpo e imagem na arte contemporânea brasileira a partir de obras que suscitam operações de reapropriação do real. Para isso, propusemos uma articulação entre as produções poéticas de Nuno Ramos e Rosangela Rennó – nomeadamente entre as décadas de 1990 e 2000 – e as contribuições teóricas de Slavoj Žižek e Michel Foucault, cujo caráter não conciliatório opera um tensionamento nos discursos hegemônicos em torno do fenômeno da violência e de suas relações com a visualidade e a corporeidade.Palavras-chave: Violência; Corpo; Imagem; Nuno Ramos; Rosangela. Rennó.Abstract This article aims to investigate the relations between violence, body and image in Brazilian contemporary art based on works that evoke reappropriations from the real. For that, we propose to link the artistic productions of Nuno Ramos and Rosangela Rennó from 1992 and the theoretical works of Slavoj Žižek and Michel Foucault.Keywords: Violence; Body; Image; Nuno Ramos; Rosangela Rennó.
A QUESTÃO DO ESPAÇO E A ENUNCIAÇÃO DO SUJEITO NO TRABALHO DE DANA AWARTANI / The issue of space and the enunciation of the subject in the work of Dana Awartani
Authors: Chagas Deivisson Dias 
Published: August 2020

O presente artigo analisa a questão do processo colonial e de subalternização problematizado na obra “I went away and forgot you. A while ago I remembered. I remembered I’d forgotten you. I was dreaming”, da artista saudita Dana Awartani. Misto de site specific e registro fílmico de performance, o trabalho dialoga com a insurgência de novos sujeitos na produção de arte contemporânea, denominados por Gayatri C. Spivak de “sujeitos subalternos”, e com as mudanças ocorridas entre as décadas de 1960 e 1990 em torno do conceito de site specific, como teorizado pela crítica de arte Miow Kwon.Palavras-chave: Site-specific; Performance; Sujeito; Subalternidade.AbstractThis paper analyzes the issue of space and the colonized subject in the work “I went away and forgot you. A while ago I remembered. I remembered I’d forgotten you. I was dreaming”, by saudi artist Dana Awartani. Mixed with site specific art and filmic performance record, the work dialogues with the insurgency of new subjects in the production of contemporary art in contexts against hegemonic and critical subalternity, as well as with the changes that occurred from the 1960s to the present day in around the concept of space specificity.Keywords: Site specific art; Performance; Subject; Subalternity.
Scaffolds for Drug Delivery in Tissue Engineering
Authors: V. Gaikwad Vikas , B. Patil Abasaheb , V. Gaikwad Madhuri 
Published: August 2020

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth. Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.
A New Method for Determination of Tolterodine and its Related Impurities in Active Pharmaceutical Ingredient by HPLC
Authors: Rao Tentu Nageswara , Karri Apparao , Prathipati Revathi , Botsa Parvatamma 
Published: August 2020

Tolterodine is used to treat overactive bladder symptoms such as loss of bladder control (incontinence) or a frequent need to urinate. A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of tolterodine and related impurities. The chromatographic separations were achieved on (250 × 4.6 mm), 5.0 µm make: symmetry, C8 column employing methanol and 0.1% orthophosphoric acid in water, in the ratio of 90:10 as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The column temperature was maintained at 35oC and a detector wavelength of 220 nm was employed. The method was successfully validated by establishing system suitability, specificity, linearity, accuracy, LOD and LOQ. The validated method is useful for tolterodine assay in pharmaceutical products.
Evaluation of Antiurolithiatic Activity of Lawsonia inermis Linn. in Rats
Authors: M Patel Kruti , Shah Samir K 
Published: August 2020

Lawsonia inermis Linn., commonly called as Henna belongs to family Lythraceae. Traditionally, it has been reported to have therapeutic activity in bronchitis, diabetes, antimicrobial, antibacterial, trypsin inhibitory, cytotoxicity, wound healing, antioxidant, anti-inflammatory, analgesic. However, the antiurolithiatic activity of the bark extract of L. inermis Linn. is not known. In this study, we investigated protective effect of the alcoholic extract of L. inermis bark against ethylene glycol induced urolithiasis and its possible underlying mechanisms using male wistar albino rats. Animals were divided into seven groups and urolithiasis was induced by ethylene glycol (0.75% v/v) in drinking water for 28 days. Methanolic extract of Lawsonia inermis (MELI) bark (300 & 500 mg/kg, p.o.) were administered once daily from 15th day to 28th day as curative regimen and from 1st day to 28th day as preventive regimen. Cystone (750 mg/kg, p.o.) was used as a standard drug. After 28 days, various biochemical parameters like urine volume, pH were measured. Calcium, phosphate and oxalate were measured in urine and kidney homogenate. Serum creatinine, uric acid and urea nitrogen were estimated. Histopathology of kidney also studied. Treatment with the MELI extract significantly restored all elevated parameters including calcium, phosphate and oxalate in urine and kidney homogenate; creatinine, uric acid and urea nitrogen in serum when compared to model control group. The histopathological study of the kidney also supported the above results. It can be concluded that methanolic extract of bark of Lawsonia inermis Linn. has significant antiurolithiatic effect in experimental rats.
Preparation and In vivo Evaluation of Mucoadhesive Microspheres for Gastroretentive Delivery of Misoprostol
Authors: D.V. R. N. Bhikshapathi , K Ranjith Kumar 
Published: August 2020

The aim of the present investigation was to prepare and evaluate the Misoprostol mucoadhesive microspheres for gastroretentive drug delivery. Sodium alginate and sodium carboxy methyl cellulose were used as mucoadhesive polymers. Microsphere formulations were prepared using Ionotropic gelation technique. All the microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, percentage yield, drug entrapment, stability studies and for in vitro release kinetics. Based on the results, the formulation M12 was selected as optimized formulation. In vitro drug release study of optimized formulation M12 showed 98.23% after 12 h in a controlled manner, which is essential for anti ulcer therapy. The marketed product shows the drug release of 95.23 within 1 h. The results of mucoadhesion study showed better retention of prepared microspheres (8) h in chic duodenal and jejunum regions of intestine. The results showed significant higher retention of mucoadhesive microspheres in upper GI tract. Pharmacokinetic study revealed that the bioavailability was found to be increased significantly when compared with marketed tablets. The drug release of Misoprostol optimized formulation M12 followed zero order, Higuchi and Korsmeyer-Peppas kinetics indicating diffusion controlled with non-Fickian (anomalous) transport thus it projected that delivered its active ingredient by coupled diffusion and erosion. Overall, the result indicated prolonged delivery with improved bioavailability of Misoprostol from mucoadhesive microspheres due to higher retention in the upper GI tract.
Development and Evaluation of Olmesartan Medoxomil Controlled Release Floating Microspheres using Natural Gums
Authors: Kota Ravi Kumar , Gande Suresh 
Published: August 2020

The present research was aimed to prepare Olmesartan medoxomil floating microspheres for controlled release using polymers such as sodium alginate, sodium bicarbonate, calcium chloride, Hydroxy propyl methyl cellulose (HPMC K4M, K15M), Olibanum gum and Xanthan gum by ionotropic gelation method. The prepared microspheres were evaluated for the percent drug content, entrapment efficiency, percentage buoyancy and in vitro dissolution studies. Among all the formulations F14 was selected as optimized formulation based on the micromeretic and physico-chemical parameters including drug release studies. Percentage buoyancy of optimized formulation was found to be 96.45%. In vitro release study of formulation F14 showed 98.11% drug release after 12 h in a controlled manner, which is desired for disease like Hypertension. The reference standard shows the drug release of 94.12% within 12 h. Drug and excipient compatibility studies were carried out by FT-IR and no interactions were observed. The SEM of microspheres show a hollow spherical structure with a rough surface morphology. Some of microspheres showed dented surface structure but they showed good floating ability on medium indicated intact surface. The shell of microspheres also showed some porous structure which might be due to release of carbon dioxide. F14 followed zero order, Higuchi and Korsmeyer Peppas kinetics indicating diffusion controlled with non-fickian (anomalous) transport, projecting that its active ingredient are delivered by coupled diffusion and erosion. From these results, it can be concluded that the polymer proportion controlled the drug release from the olmesartan floating microspheres.
Formulation and Evaluation of Sustained Release Floating Tablets of an Antihypertensive Diltiazem
Authors: Kulkarni Gururaj S , Chaudhary Prabhansh P , Swamy Shivakumar 
Published: August 2020

The aim of the present study was to develop and evaluate sustained release floating tablets of Diltiazem hydro-chloride, an antihypertensive agent. The sustained release floating tablets were prepared by direct compression method and formulated using different polymer combinations, formulations such as F1 to F9. Natural polymer Sodium alginate and synthetic polymer HPMC K4M were used. Developed formulations were evaluated for the pre compression parameters i.e., drug- excipients compatibility by FTIR, bulk density, compressibility, and angle of repose etc. Post compression parameters i.e. weight variation; full factorial design was applied to optimize the developed formulation. SA and HPMC K4M were selected as independent variable at three different concentrations. The in-vitro drug release study revealed that formulation F8 combination of both synthetic (HPMC) and natural polymers (sodium alginate) was the most successful formulation of the study, all tablets but one exhibited gradual and near complete sustained release for diltiazem HCl (90-100%) that extended the drug release up to 8 hours, with satisfactory drug release in the initial hours, and the total release pattern was close to the theoretical release profile. Model equations of zero and first order, Higuchi, Hixson-Crowell and Peppas, intended to elucidate the drug release mechanism, and were fitted to the release data. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Higuchi model with r2 vales of 0.994 in its semi log plot. The ‘n’ value in Higuchi model was >0.89 which indicated, Super Case-II transport of drug from polymer sustained, i.e., diffusion with relaxation of polymeric chain. In conclusion, the results indicated that the prepared sustained-release tablets of Diltiazem hydrochloride could perform therapeutically better than conventional tablets with improved efficacy and better patient compliance.