bluuebunny/crossref_metadata_2025_split huggingface dataset:
New number-theoretic cryptographic primitives
Authors: Brier Éric , Ferradi Houda , Joye Marc , Naccache David 
Published: November 2019

AbstractThis paper introduces new prq-based one-way functions and companion signature schemes. The new signature schemes are interesting because they do not belong to the two common design blueprints, which are the inversion of a trapdoor permutation and the Fiat–Shamir transform. In the basic signature scheme, the signer generates multiple RSA-like moduli ni = pi2qi and keeps their factors secret. The signature is a bounded-size prime whose Jacobi symbols with respect to the ni’s match the message digest. The generalized signature schemes replace the Jacobi symbol with higher-power residue symbols. Given of their very unique design, the proposed signature schemes seem to be overlooked “missing species” in the corpus of known signature algorithms.
Quaternary Bit-Swap Logic with QPSK Signal Using Four Wave Mixing
Authors: Chandra Sutanu Kumar , Biswas Subhendu 
Published: November 2019

Abstract
Multilevel modulation formats have been now investigated very much to increase the speed and data capacity of optical communication networks in the limited bandwidth. Quadrature phase modulated signal has captured the attention of the researchers in this aim due to its high spectral efficiency and less bit error rate. Quaternary Bit-Swap logic operation is very important fundamental logic operation related to fast and secure computing and communication. Here in this report the authors propose a new method of implementation of all-optical quaternary Bit-Swap logic operation with quadrature phase modulated signal using four wave mixing.
Effects of Laser Linewidth on the Performance of DP-QPSK DWDM System
Authors: Sharma Neeraj , Agrawal Sunil , Kapoor Vinod , Budhiraja Sumit 
Published: November 2019

Abstract
This paper analyzes the effects of laser linewidth on the performance of eight-channel dual-polarization quadrature phase-shift keying (DP-QPSK) dense wavelength division multiplexing (DWDM) transmission at 50 GHz channel spacing. The performance of differential encoding and Gray coding is compared with the system without any coding for the DP-QPSK DWDM system. It is shown that the differentially-encoded system performs better for lasers with linewidth (∆ν) greater than 0.04 MHz compared to the system with Gray coding and system without any coding. However, for lasers with linewidth lesser than 0.04 MHz, the three systems considered here perform equally and there is no need for differential or Gray coding in such a case. It is also shown that if we apply frequency offset estimation (FOE) before adaptive equalization (AE) in the digital coherent receiver then it further improve the performance of the differentially encoded system with lasers sources having linewidth even greater than 0.1 MHz.
Estimated glomerular filtration rate in patients overdosed with gentamicin
Authors: Šálek Tomáš , Vodička Martin , Gabrhelík Tomáš 
Published: November 2019

Abstract

Background
The aim of this study was to compare the estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcrea) and cystatin C (eGFRcys) in patients with elevated serum trough levels of gentamicin before the next planned dose during treatment in the intensive care unit (ICU).

Methods
This was a retrospective observational study. Patients who stayed in an ICU, received a once-daily dose of gentamicin, and who had results from all serum gentamicin trough levels, eGFRcrea and eGFRcys analyses were included in the study. Overdosed patients were defined as those with serum gentamicin trough levels above 1 mg/L before the next dose. Gentamicin was measured by a particle-enhanced turbidimetric immunoassay (PETIA). Creatinine and cystatin C were measured by standardized methods.

Results
The median age (range) was lower in all patients with gentamicin concentration measurements than in overdosed patients (67 [19–96] vs. 75 [48–99] years, respectively; p < 0.0001). The median interquartile range (IQR) of the eGFRcrea was higher than that of the eGFRcys in overdosed patients (60 [44–79] mL/min/1.73 m2 vs. 41 [29–58] mL/min/1.73 m2, respectively; p < 0.0001). The median IQR of the eGFRcrea was higher than that of the eGFRcys in controls (87 [78–98] mL/min/1.73 m2 vs. 66 [54–93] mL/min/1.73 m2, respectively; p < 0.0001).

Conclusions
Overdosed patients had both a lower eGFRcrea and eGFRcys than controls. Elderly patients are the most commonly overdosed patients. We recommend measuring cystatin C and calculating the eGFRcys and combined equation (eGFRcrea + cys) in ICU patients over 65 years of age, which would enable improved gentamicin dosage adjustments.
The areal typology of western Middle and South America: Towards a comprehensive view
Authors: Urban Matthias , Reyes-Centeno Hugo , Bellamy Kate , Pache Matthias 
Published: November 2019

AbstractAgainst a multidisciplinary background this contribution explores the areal typology of western Middle and South America. Based on a new language sample and a typological questionnaire that is specifically designed to bring some of the poorly documented and extinct languages into the debate, we explore the areal distribution of 77 linguistic traits in 44 languages. While one of the goals of the present article is to provide a general up-to-date view of the areal patterning of these traits on a large scale, we also explore a number of specific questions in more detail. In particular, we address the relationship between known language areas like Mesoamerica and the Central Andes with their respective peripheries, the possibility of detecting an areal-typological signal that predates the rise of these linguistic areas, and, finally, the question of linguistic convergence along the Pacific coast. We find that, while the languages of the Mesoamerican periphery are rather diffuse typologically, the structural profiles of the Central Andean languages are embedded organically into a more general cluster of Andean typological affinities that alters continuously as one moves through geographical space. In different ways, the typological properties of the peripheral languages may reflect a situation that goes back to time depths which are greater than that of the emergence of the Mesoamerican and Central Andean linguistic areas. Finally, while we can confirm typological affinities with Mesoamerica for some languages of coastal South America, we do not find support for large-scale linguistic convergence on the Pacific coast.
First record of existence of Rhinolophus malayanus (Chiroptera, Rhinolophidae) in China
Authors: Liang Jie , He Xiangyang , Peng Xingwen , Xie Huanwang , Zhang Libiao 
Published: November 2019

Abstract

Rhinolophus malayanus has been found in several countries in Southeast Asia, including Vietnam, Thailand, Malaysia, Laos, and Myanmar. In 2015, we found three small Rhinolophus bats in Mengla County, Yunnan, China. Results of morphological and molecular examinations identified them as R. malayanus. This is the first record of existence of R. malayanus in China. This study advanced our knowledge of bat distribution and provided important information for further studies of various aspects of R. malayanus in China.
Crystal structure of 5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-(2,2-dichloroacetyl)-3,4-dihydro-2 H-benzo[b][1,4]oxazine-7-carboxylate, C19H19Cl2NO5
Authors: Guo You-Yuan , Wang Huan , Ma Xin , Fu Ying 
Published: November 2019

Abstract
C19H19Cl2NO5, orthorhombic, Pbca (no. 61), a = 12.6750(18) Å, b = 11.0927(17) Å, c = 28.400(4) Å, V = 3993.0(10) Å3, Z = 8, R
gt(F) = 0.0700, wR
ref(F
2) = 0.2011, T = 293(2) K.
Crystal structure and anti-inflammatory activity of (3E,5E)-3-(2-fluorobenzylidene)-1-((4-acetamidophenyl)sulfonyl)-5-(pyridin-3-ylmethylene)piperidin-4-one-methanol-hydrate (2/1/1), C53H50F2N6O10S2
Authors: Wang An-Qi , Gao Ru-Ning , Luan Qing-Hao , Wang Ze-Ping , Li Xiao-Ming , Hou Gui-Ge 
Published: November 2019

Abstract
C53H50F2N6O10S2, monoclinic, P21/n (no. 14), a = 15.088(5) Å, b = 23.560(9) Å, c = 15.401(6) Å, β = 112.254(5)°, V = 5067(3) Å3, Z = 4, R
gt(F) = 0.0509, wR
ref(F
2) = 0.1336, T = 298(2) K.
The crystal structure of 2-oxo-2H-chromen-4-yl acetate, C11H8O4
Authors: Hulushe Siya T. , Manyeruke Meloddy H. , Hosten Eric C. , Kaye Perry T. , Watkins Gareth M. , Krause Rui W. M. 
Published: November 2019

Abstract
C11H8O4, monoclinic, P21/c (no. 14), a = 4.5947(2) Å, b = 10.5414(3) Å, c = 19.1611(7) Å, β = 94.084(2)°, V = 925.70(6) Å3, Z = 4, R
gt(F) = 0.0376, wR
ref(F
2) = 0.1109, T = 200(2) K.
Spiritualität in der Kommunikation bei humanitärer internationaler Nothilfe?
Authors: Schneider Martin 
Published: November 2019

Zusammenfassung
Internationale Gesundheitsfachleute sollen bei Einsätzen mit humanitären Nothilfeorganisationen auch Palliativpflege berücksichtigen. Das ist eine Herausforderung, bei der interkulturelle Kommunikation, gesellschaftliche Gepflogenheiten zum Lebensende und die Umstände am Einsatzort zusammenkommen. Dazu gesellen sich die Schwierigkeiten der Arbeit mit Dolmetschern. Spiritualität gehört zur Palliativpflege. Sie ist mehr oder weniger offensichtlich in den Kulturen und Sprachen der Fachleute und der Patienten am Einsatzort vorhanden. In der Komplexität der humanitären Nothilfe und abhängig von der Lage am Einsatzort erscheint Spiritualität unterschiedlich klar wahrnehmbar. Ihr Platz hängt auch davon ab, wie weit alle Beteiligten an dieser interkulturellen Kommunikation bereit sind, sich auf Spiritualität einzulassen.
Independent Origin of XY and ZW Sex Determination Mechanisms in Mosquitofish Sister Species
Authors: Kottler Verena A , Feron Romain , Nanda Indrajit , Klopp Christophe , Du Kang , Kneitz Susanne , Helmprobst Frederik , Lamatsch Dunja K , Lopez-Roques Céline , Lluch Jerôme , Journot Laurent , Parrinello Hugues , Guiguen Yann , Schartl Manfred 
Published: November 2019

Abstract
Fish are known for the outstanding variety of their sex determination mechanisms and sex chromosome systems. The western (Gambusia affinis) and eastern mosquitofish (G. holbrooki) are sister species for which different sex determination mechanisms have been described: ZZ/ZW for G. affinis and XX/XY for G. holbrooki. Here, we carried out restriction-site associated DNA (RAD-) and pool sequencing (Pool-seq) to characterize the sex chromosomes of both species. We found that the ZW chromosomes of G. affinis females and the XY chromosomes of G. holbrooki males correspond to different linkage groups, and thus evolved independently from separate autosomes. In interspecific hybrids, the Y chromosome is dominant over the W chromosome, and X is dominant over Z. In G. holbrooki, we identified a candidate region for the Y-linked melanic pigmentation locus, a rare male phenotype that constitutes a potentially sexually antagonistic trait and is associated with other such characteristics, e.g., large body size and aggressive behavior. We developed a SNP-based marker in the Y-linked allele of GIPC PDZ domain containing family member 1 (gipc1), which was linked to melanism in all tested G. holbrooki populations. This locus represents an example for a color locus that is located in close proximity to a putative sex determiner, and most likely substantially contributed to the evolution of the Y.
Changes of exosomal matrix metalloproteinases level in colorectal cancer associated with sex and metabolic disturbance
Authors: Yunusova N. V. , Zambalova E. A. , Patysheva M. R. , Dimcha A. A. , Cheremisina O. V. , Afanas’ev S. G. , Kondakova I. V. 
Published: November 2019

The objective is to evaluate the contents of matrix metalloproteinases (MMP) MMP9, MMP2, as well as their inducer EMMPRIN in circulating exosomes of patients with colorectal cancer in relation with clinical and morphological parameters, as well as with the presence of metabolic syndrome to search for promising exosomal markers associated with invasion, metastasis and metabolic disorders.Materials and methods. The study included 40 patients with colorectal cancer (T2–4N0–2M0–1) and 10 control patients. Exosomes of blood plasma were isolated by ultrafiltration with ultracentrifugation. The level of MMP9, MMP2 and their inducer EMMPRIN in exosomes was evaluated by flow cytometry.Results and conclusion. The level of MMP9‑positive exosomes was significantly higher in patients with colorectal cancer compared with patients with colorectal polyps. The proportion of MMP9‑negative and triple positive MMP9 + / MMP2+ / EMMPRIN+ exosomes, on the contrary, was higher in patients with polyps compared with patients with colorectal cancer. Mixed subpopulation of MMP9+ / MMP2– / EMMPRIN-exosomes prevailed both in patients with colorectal cancer and in control patients. There were no significant differences in the subpopulations of MMP and EMMPRIN in the exosomes of colorectal cancer patients depending on the age, stage, grade and localization. Gender differences in the occurrence of a triple-positive exosome subpopulation in colorectal cancer patients have been revealed. No relationship was found between the expression of MMP and EMMPRIN in exosomes and the presence of the metabolic syndrome, anthropometric parameters, the level of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol. However, the relationships between MMP9+ / MMP2– / EMMPRIN–, MMP9+ / MMP2– / EMMPRIN– and the level of triglycerides and glucose in blood serum were revealed. Further studies are needed to study the characteristics of exosomes associated with metabolic disorders and the possibility of their use as diagnostic, prognostic, or predictor biomarkers.
The level of some blood serum inflammatory factors in depending on the morphological features of the primary tumor of of cervical cancer
Authors: Kayukova E. V. , Belokrinitskaya T. E. , Sholokhov L. F. , Tereshkov P. P. 
Published: November 2019

Background.Tumors influence on various vital processes in organism leading to cachexia, immunosuppression, anemia, changes in humoral regulation etc. Inflammation is one of the well-known etiological factors of carcinogenesis, including for cervical cancer, so we suggest that some blood serum inflammatory factors in patients with cervical cancer influence are associated with the level of tumor progression.The objectiveof our study was to analyze the level of some hematological markers of inflammation in the blood serum of patients with cervical cancer in dependence on the histological characteristics of the primary tumors.Materials and methods.In the study we analyzed the blood serum of patients with invasive cervical cancer I–IV stage (4 patients with verrucous cancer and 26 – with cervical cancer among them 10 – of G1 stage, 6 – of G2 stage, 10 – G3 stage) using flow cytometry. We studied the value of myoglobin, calprotectin, lipocalin, matrix metalloperoxidase 2, matrix metalloperoxidase 9, osteopontin, myeloperoxidase, serum amyloid A, protein 4, insulin-like growth factor-binding protein 4, cell-cell adhesion molecule 1, vascular cell adhesion molecule, cystatin С.Results.We revealed the changes of some serum markers of inflammation in patients with G3 and verrocous cervical cancer.Conclusion.The obtained dates demonstrate that further study of blood inflammatory markers as an additional differential and prognostic criteria in patients with cervical cancer should be considered as reasonable.
Differences in the profile of cytokine expression induced by implantation of oncogenic and non-oncogenic millipore filters
Authors: Rybalkina E. Yu. , Susova O. Yu. , Moizhess T. G. 
Published: November 2019

Background. Clarification of the mechanisms of carcinogenesis induced by foreign bodies is one of the urgent problems of modern oncology. This is due to the fact that there is a relationship between the processes of inflammation and carcinogenesis. Today, there is no doubt the fact that cytokines and signal molecules in the focus of inflammation (products of inflammation) can contribute to the initiation of carcinogenesis, as well as stimulate tumor progression. In the case of carcinogenesis induced by foreign bodies, the key issue is understanding the differences in the body’s response to the implantation of foreign bodies that can cause tumor formation and do not have this ability. One of the phenomena of this type of carcinogenesis is the occurrence of sarcoma after the subcutaneous implantation in mice of hydrophilic millipore filters with a pore diameter not exceeding 0.1 μm and the inability to induce tumors of one’s with a pore diameter greater than or equal to 0.22 μm.The objective of our work was to study the differences between oncogenic and non-oncogenic filters at the molecular level.Materials and methods. Reverse transcription polymerase chain reaction method was used to study the expression of a number of cytokines that are products of macrophage cells that live on the surface of implanted filters and in the surrounding capsule. Filters with pore diameters of 0.025 μm (carcinogenic) and 0.45 μm (non-carcinogenic) were compared in 8, 35 days and 5.5 months after implantation.Results and conclusion. After 8 days we observed significant (p <0.01) excess of expression of two cytokines interleukin 1β (IL-1β) by cells around oncogenic filters (with pore of 0.025 μm) compared to non-oncogenic one’s (with pore of 0.45 μm) After 35 days, significant (p <0.01) excess of expression of IL-1β, Tnf-α, iNOS (induced nitric oxide synthase), and IL-6 by cells around the oncogenic filters (0.025 μm) compared to non-oncogenic one’s (0.45 μm) was observed. There was no quantitative difference in the expression of Nf-κB1 and Nf-κB2 (nuclear factor κ-B1, κ-B2), Tgf-β (transforming growth factor β), IL-10. After 5.5 months the expression of IL-1β by cells on oncogenic filters was still significant; for Tnf-α, iNOS, IL-6 and IL-10 there was no practically difference in expression. For Nf-κB1 and Nf-κB2, Tgf-β and COX-2 (cyclooxygenase 2) the difference was significant, cells on non-oncogenic filters are expressed more then on oncogenic one’s.
Modern approaches for the screening of epigenetically active xenobiotics
Authors: Maksimova V. P. , Bugaeva P. E. , Zhidkova E. M. , Usalka O. G. , Lesovaya E. A. , Belitsky G. A. , Yakubovskaya M. G. , Kirsanov K. I. 
Published: November 2019

Objective. Review of the modern methodological approaches for testing and studying the epigenetic activity of xenobiotics.Materials and methods. In preparing the review, we used information databases of biomedical literature SciVerse Scopus (538), PubMed (746), Web of Science (625), RSCI (45). To obtain full-text documents, electronic resources of PubMed Central (PMC), Research Gate, RSCI, CyberLeninka were used. In the text of the review, 87 modern publications (2010–2019) were cited, as well as 17 earlier articles published by the founders of the methods, which are used today.Results. In the review, current data on epigenetic regulation for gene expression at the level of DNA methylation and histone modification are discussed, in vitro model systems and model organisms are described, and modern methods for screening of epigenetically active xenobiotics are presented.Conclusion. Modern data concerning the mechanisms of epigenetic regulation of gene expression, the usage of existing model systems and model organisms, as well as the application of various methodological approaches and techniques, allow extensive screening of xenobiotics (including drugs and compounds synthesized for national economic tasks) for epigenetic activity. The identification of epigenetically active compounds is important in terms of improving the prevention and treatment of a number of diseases and, in particular, malignant neoplasms.
Blended Learning between Team Games Tournament and Web-Based Module to Improve Students’ Competency of Light Vehicle Programs
Authors: Wijaya Robby , Widiyanti Widiyanti , Suhartadi Syarif , Basyirun Basyirun 
Published: November 2019

Education plays an important role in printing Human Resources (HR), includingvocational schools. Learning methods and the availability of learning resources becomes very important and needed. The existence of the internet needs to be utilized to create innovative and interesting learning. The research method used is Classroom Action Research (CAR) which aims to determine the effect of the implementation of the blended learning team games tournament (TGT) and the Web-Based Module as an Effort to Increase the Achievement of Student Competencies in the Light Vehicle Engineering Program. The study was onducted in class X TKR 1, SMKN 1 Singosari in the 2017-2018 school year as many as 32 students. The treatment is given consisted of Action 1and Action 2 by observing the activities of the teacher, students, and post-test scores. In the pre-action, the percentage of completeness obtained was 67.74% while the Minimum Completeness Standard was 75%. After action 1, the achievement of student competence reached 93.5% with an average value of 86.53. While in Action 2, student learning completeness was 87.09% with an average value of 81.3. From the two actions implemented, it is found that the average results are above the minimum standard of a predetermined value of 75. The application of blended learning can improve student learning outcomes because the learning process is more interesting, active and innovative. students are more enthusiastic and happy with the learning model. With the tournament, students are trained to be responsible, care for friends, study independently and compete healthily. The application of Blended Learning team games tournament (TGT) and Web-based modules are recommended to be applied to other subjects because it is proven to be able to increase the achievement of student competencies and to be creative, innovative and interesting method.
STRATEGIES THAT INCREASE THE LEVEL OF LISTENING COMPREHENSION WHILE LISTENING TO ORAL TEXTS
Authors: Rubtcova Mariia , Varlamova Yulia 
Published: November 2019

The present paper examines the effectiveness of strategy instructional program elaborated for 120 intermediate students with different previous learning backgrounds attending language center in Saint Petersburg. The objective of the study is to develop program and improve the level of listening comprehension through focusing on potential problems while doing listening tasks. The study either aims at determining and mastering cognitive, metacognitive, social strategies on the part of the students. The authors hypothesize that learners can gain proficiency in using strategies with practice. Strategies can be easily acquired, they facilitate learning, however, number of them are not always transferred to new tasks and used by students as effectively as before when the activity is over. Therefore, systematic strategy instruction component would be important as learners become aware of the learning process and gain the ability to control their own learning through the use of appropriate learning strategies. The authors of the paper have made an attempt to demonstrate that the number of listening comprehension problems reported by the students could be reduced by applying specially designed comprehension activities that assist learners in evaluation of their efforts and assessment of personal achievements. The pilot groups were asked to complete the questionnaires at the beginning and at the end of the course that allowed monitoring the students’ progress throughout the course. At the end of the study, the pilot groups participating in the strategy instructional program were found to be more successful in foreign language comprehension.