bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereotactic ablative radiotherapy (SABR) for recurrent and previously irradiated head and neck cancers
Authors: Anand Anil Kumar , Dua Bharat , Bansal Anil Kumar , Singh Heigrujam Malhotra , Verma Amit , Kumar Amit 
Published: February 2020

Objective: To assess the response and toxicity of stereotactic ablative radiotherapy (SABR) in patients with recurrent head and neck cancer (HNC), who had previously received radiation for their primary tumor. Methods: Between 2014 and 2018, patients who received SABR to recurrent HNC within the previously irradiated region were retrospectively reviewed. Mean age was 60 years (range 30–78 Years). Histology was confirmed in all patients. MRI and /or CT-positron emission tomography were done to evaluate local extent and to rule out metastasis. Response was assessed as per RECIST/PERCIST Criteria. Cox proportional hazards regression and the Kaplan–Meier methods were used for statistical analysis. Results: 32 patients received SABR. RPA Class II, III patients were 20 and 12 respectively. 87% patients received a dose of ≥30 Gy/5 fractions. Median follow-up was 12 months. Estimated 1 year and 2 years local control was 64.2 and 32% and 1 year and 2 years overall survival was 67.5 and 39.5% respectively. Acute Grade 2 skin and Grade 3 mucosal toxicity was seen in 31.3 and 28% patients respectively. Late Grade 3 toxicity was seen in 9.3% patients. Conclusion: Re-irradiation with SABR yields high local control rates and is well tolerated. It compares favorably with other treatment modalities offered to patients with recurrent HNC. It is also suitable for patients of RPA Class II and III. There is need for novel systemic agents to further improve the survival. Advances in knowledge: Treatment of patients with recurrent HNC is challenging and is more difficult in previously radiated patient. More than 50% patients are unresectable. Other options of salvage treatment like re-irradiation and chemotherapy are associated with poor response rates and high incidence of acute and late toxicity (Gr ≥3 toxicity 50–70%). SABR is a novel technology to deliver high dose of radiation to recurrent tumor with high precision. It yields high local control rates with less toxicity compared to conventionally fractionated radiation.
Diode-pumped triple-clad fiber MOPA with an output power scaling up to 4.67  kW
Authors: Kalyoncu Salıh K. , Mete Busra , Yenıay Aydın 
Published: February 2020

In this Letter, we have demonstrated a triple-cladded fiber (TCF)-based master oscillator power amplifier (MOPA), with an output power scaling up to 4.67 kW, an optical-to-optical efficiency of 78%, and a beam quality factorM2of 1.57. The MOPA output power was limited by stimulated Raman scattering (SRS) of which our design yielded a 31.2 dB suppression ratio at the 4.67 kW output power. Such a unique design of a TCF-based structure allows a wide range of flexibility over fiber parameters, mitigation of nonlinear effects, low-loss splice integration, reliable high-power pump guiding in turn, and an ease in overall thermal management at multi-kW output power levels. Together with direct diode-pumping configuration, TCF-based designs promise thermally and mechanically robust, compact, and highly efficient MOPA systems of a superior beam quality.
Esophageal Squamous Cell Carcinoma With Colonic Metastases
Authors: Wiseman Daniel , Ferri Lorenzo , Lakatos Peter L. , Fiset Pierre-Olivier , Bessissow Talat 
Published: February 2020

ABSTRACT
Esophageal squamous cell carcinoma (ESCC) is recognized as one of the most lethal malignancies worldwide. The disease's tendency to quickly metastasize precludes many patients from receiving curative therapy. The most common sites of distal metastases include the liver, lungs, bones, and brain. We report a case of ESCC metastasizing to the rectosigmoid region years after treatment with neoadjuvant chemoradiation and esophagectomy. To our knowledge, only a handful of cases of ESCC with colonic metastases have been previously documented.
Impoliteness in negative online consumer reviews: A cross-language and cross-sector comparison
Authors: Feng Wei , Ren Wei 
Published: February 2020

AbstractThis article presents a multifaceted comparative investigation into the linguistic impoliteness in the negative online consumer reviews on one of the world’s largest e-commerce tycoons and the flagship giant Amazon. The findings were derived from 600 items of online consumer reviews from two comparative perspectives: cross-language (English vs. Chinese) and cross-sector (daily necessities vs. luxury goods). Four impoliteness strategies were identified, calculated and illustrated based on the collected dataset, ranging from January 2016 to October 2018. Findings indicate that in terms of decreasing frequency, the impoliteness strategies reviews are positive impoliteness, implicated impoliteness, negative impoliteness and sarcasm in the negative online consumer reviews of both languages and both sectors. The results reveal that, regardless of sector and language differences, on-record impoliteness is much more frequent than off-record impoliteness in the genre of online consumer reviews. Despite of similarities, discrepancies were also found with regard to the employment of impoliteness strategies in online consumer reviews across languages and sectors. As a timely effort, the findings offer impoliteness-related insights and implications to both theorists and practitioners in the e-commerce industry.
The complex experience of psoriasis related skin pain: a qualitative study
Authors: Ljosaa Tone Marte , Bondevik H. , Halvorsen J.A. , Carr E. , Wahl A.K. 
Published: February 2020

Abstract

Background and aims
Psoriasis is a common chronic skin condition, causing skin lesions with thickened and scaling skin, as well as erythema and inflammation that may involve painful sores, cracks, and pustules. Previously psoriasis was regarded as a painless skin condition. However, over the past decade studies show that skin pain is a frequently reported and bothersome symptom in patients with psoriasis. There is however a lack of rich narratives describing the experience of skin pain in these patients. The aims of this qualitative study were therefore to explore in depth how patients experience psoriasis-related skin pain, and how they deal with it.

Methods
Thirteen patients with psoriasis were recruited from a dermatology ward and outpatient clinic. One of the investigators (TML) performed individual, semi-structured interviews at an undisturbed room in the hospital. Interviews were thematically analyzed using the method of Systematic Text Condensation as described by Malterud (2012).

Results
Three main themes were identified from the interviews. First, the skin pain experience was complex. Patients used a variety of adjectives and metaphors to describe their pain, and their skin was sensitive to stimuli of every-day activities. Itch was a common cosymptom, and could both mask pain but also cause severe pain due to excessive scratching and damage to the skin. Second, skin pain had a negative impact on patients’ life. Skin pain reduced their physical activity level, impaired their sleep, and made them irritable, depressed, unconcentrated on tasks, as well as withdrawn from other people and social activities. Third, patients dealt with their skin pain in various ways. Although some took action to relieve the pain and distract themselves from pain, most of the patients applied maladaptive and passive coping strategies such as put up with it, avoid painful activities, become fearful or trivialize their pain.

Conclusions
The experience of psoriasis related skin pain is complex. The pain has a major negative impact on patients’ life in terms of physical, emotional, cognitive, and social functions. Patients use a variety of adaptive but most frequently maladaptive coping strategies in order to deal with their skin pain.

Implications
This study provides new and in-depth knowledge on psoriasis related skin pain. This information is valuable for further work on pain assessment tools and pain management recommendations customized for skin pain experienced by patients with psoriasis.
Dopamine Receptor Dop1R2 Stabilizes Appetitive Olfactory Memory through the Raf/MAPK Pathway inDrosophila
Authors: Sun Huan , Nishioka Tomoki , Hiramatsu Shun , Kondo Shu , Amano Mutsuki , Kaibuchi Kozo , Ichinose Toshiharu , Tanimoto Hiromu 
Published: February 2020

InDrosophila, dopamine signaling to the mushroom body intrinsic neurons, Kenyon cells (KCs), is critical to stabilize olfactory memory. Little is known about the downstream intracellular molecular signaling underlying memory stabilization. Here we address this question in the context of sugar-rewarded olfactory long-term memory (LTM). We show that associative training increases the phosphorylation of MAPK in KCs, via Dop1R2 signaling. Consistently, the attenuation ofDop1R2,Raf, orMAPKexpression in KCs selectively impairs LTM, but not short-term memory. Moreover, we show that the LTM deficit caused by the knockdown ofDop1R2can be rescued by expressing active Raf in KCs. Thus, the Dop1R2/Raf/MAPK pathway is a pivotal downstream effector of dopamine signaling for stabilizing appetitive olfactory memory.SIGNIFICANCE STATEMENTDopaminergic input to the Kenyon cells (KCs) is pivotal to stabilize memory inDrosophila. This process is mediated by dopamine receptors like Dop1R2. Nevertheless, little is known for its underlying molecular mechanism. Here we show that the Raf/MAPK pathway is specifically engaged in appetitive long-term memory in KCs. With combined biochemical and behavioral experiments, we reveal that activation of the Raf/MAPK pathway is regulated through Dop1R2, shedding light on how dopamine modulates intracellular signaling for memory stabilization.
The Relationship Between Glutamate Dynamics and Activity-Dependent Synaptic Plasticity
Authors: Barnes Jocelyn R. , Mukherjee Bandhan , Rogers Ben C. , Nafar Firoozeh , Gosse Madeline , Parsons Matthew P. 
Published: February 2020

The spatiotemporal dynamics of excitatory neurotransmission must be tightly regulated to achieve efficient synaptic communication. By limiting spillover, glutamate transporters are believed to prevent excessive activation of extrasynaptically located receptors that can impair synaptic plasticity. While glutamate transporter expression is reduced in numerous neurodegenerative diseases, the contributions of transporter dysfunction to disease pathophysiology remain ambiguous as the fundamental relationship between glutamate dynamics and plasticity, and the mechanisms linking these two phenomena, remain poorly understood. Here, we combined electrophysiology and real-time high-speed imaging of extracellular glutamate transients during LTP induction and characterized the sensitivity of the relationship between glutamate dynamics during theta burst stimulation (TBS) and the resulting magnitude of LTP consolidation, both in control conditions and following selective and nonselective glutamate transporter blockade. Glutamate clearance times were negatively correlated with LTP magnitude following nonselective glutamate transporter inhibition but not following selective blockade of a majority of GLT-1, the brain's most abundant glutamate transporter. Although glutamate transporter inhibition reduced the postsynaptic population response to TBS, calcium responses to TBS were greatly exaggerated. The source of excess calcium was dependent on NMDARs, L-type VGCCs, GluA2-lacking AMPARs, and internal calcium stores. Surprisingly, inhibition of L-type VGCCs, but not GluA2-lacking AMPARs or ryanodine receptors, was required to restore robust LTP. In all, these data provide a detailed understanding of the relationship between glutamate dynamics and plasticity and uncover important mechanisms by which poor glutamate uptake can negatively impact LTP consolidation.SIGNIFICANCE STATEMENTSpecific patterns of neural activity can promote long-term changes in the strength of synaptic connections through a phenomenon known as synaptic plasticity. Synaptic plasticity is well accepted to represent the cellular mechanisms underlying learning and memory, and many forms of plasticity are initiated by the excitatory neurotransmitter glutamate. While essential for rapid cellular communication in the brain, excessive levels of extracellular glutamate can negatively impact brain function. In this study, we demonstrate that pharmacological manipulations that increase the availability of extracellular glutamate during neural activity can have profoundly negative consequences on synaptic plasticity. We identify mechanisms through which excess glutamate can negatively influence synaptic plasticity, and we discuss the relevance of these findings to neurodegenerative diseases and in the aging brain.
Personality types in individuals with type 1 and type 2 diabetes
Authors: Rouland A , Chauvet-Gelinier J-C , Sberna A-L , Crevisy E , Buffier P , Mouillot T , Petit J-M , Vergès B 
Published: February 2020

Objective
The Type A personality, characterized by impatience, strong career ambition and competitiveness, is associated with greater sensitivity to external stress. Type 1 diabetes (T1D) is an auto-immune disease, which is potentially influenced by stress, unlike type 2 diabetes (T2D). The aim of this study was to assess whether individuals with T1D and T2D exhibited significant differences on the Type A personality scale. We also assessed personality in patients with thyroid auto-immune diseases to validate potential links between auto-immune disease and Type A personality.

Design and methods
The Bortner questionnaire was used to assess Type A personality in 188 patients with T1D, 430 patients with T2D and 85 patients with auto-immune thyroid disease (Graves’ disease or Hashimoto’s thyroiditis).

Results
Type A Bortner scores were significantly higher in T1D patients than in T2D patients (188 ± 34 vs 177 ± 36, P < 0.0001). Patients with auto-immune thyroid diseases and T1D patients had similar Type A Bortner scores (189 ± 33 vs 188 ± 34, P = 0.860).

Conclusion
Patients with auto-immune T1D have higher Type A scores than T2D patients. Furthermore, patients with auto-immune thyroid disease also have elevated Type A scores similar to those observed in type 1 diabetes, suggesting that an elevated Type A score in T1D is potentially related to its auto-immune origin. This suggests a possible link between Type A personality and auto-immune diseases via stress-triggering psychobiological pathways. The different personality score between T1D and T2D is an important factor, which could influence self-care coping strategies in diabetes and long-term prognosis.
Force Majeure For Contract Agreement
Authors: Kostiv I.Ya. 
Published: February 2020

Agricultural production is an activity characterized by a high degree of risk. First of all it is caused by unpredictability of weather conditions and natural disasters. In addition, armed conflict in eastern Ukraine, annexation of the Crimea, strikes, industrial accidents - all these conditions affect the quantity and quality of products, as well as the timing of fulfillment of obligations.
Therefore, the topic of force majeure is extremely relevant to agricultural producers, as a basis for exemption from liability for failure or improper performance of the contract.
The onset of force majeure is the basis for the release of the guilty person from responsibility for non-fulfillment (breach) of its contractual obligation, tract, agreement. At the same time, the onset of force majeure must be duly certified (verified) in accordance with compliance with the provisions of the current legislation of Ukraine and the terms of the agreement thief, as one party to the contract may require the other payment of penalties (in case of improperly confirmed-whether or not confirmation of the occurrence of force majeure). List of circumstances of force majeure and their order confirmation is agreed by the parties directly in the contractri. Often the parties assume that the evidence of force majeure The Chamber of Commerce and Industry of Ukraine implements the most serious circumstances
The article is dedicated to understanding “force majeure” and “excessive power” as well as to the specificities of the contract for the contractual contract for the nonnegotiable settlement of the contract.
Therefore, in order to prevent the parties to the contractual contraction from possible negative situations in the future, it is necessary to determine from the outset what the circumstances will be considered as force majeure, what will confirm the occurrence of such circumstance, the timing of notification of the other party about such circumstances, etc.
Draft Genome Assembly of Floccularia luteovirens, an Edible and Symbiotic Mushroom on Qinghai-Tibet Plateau
Authors: Gan Xiaolong , Cao Dong , Zhang Zhenyu , Cheng Shu , Wei Le , Li Shiming , Liu Baolong 
Published: February 2020

Abstract
Floccularia luteovirens, also known as “Yellow mushroom”, is an edible ectomycorrhizal fungus widely distributed in the Qinghai-Tibet Plateau alpine meadow. So far, little genomic information is known about F. luteovirens, which is not conductive to the protection and utilization of it. In this manuscript, we present a first draft genome assembly and annotation of F. luteovirens. The fruiting body of F. luteovirens was sequenced with PacBio Sequel and Illumina Hiseq 2500 system. The assembled genome size was 28.8 Mb, and comprising 183 contigs with a N50 contig size of 571 kb. A total of 8,333 protein-coding genes were predicted and 7,999 genes were further assigned to different public protein databases. Besides, 400 CAZymes were identified in F. luteovirens. Phylogenetic analysis suggested that F. luteovirens should belong to the Agaricaceae family. Time tree result showed that the speciation of F. luteovirens happened approximately 170 Million years ago. Furthermore, 357 species-specific gene families were annotated against KEGG and GO database. This genome assembly and annotation should be an essential genomic foundation for understanding the phylogenetic, metabolic and symbiotic traits of F. luteovirens.
The relationship between childhood trauma and Internet gaming disorder among college students: A structural equation model
Authors: Shi Lijuan , Wang Yuanyuan , Yu Hui , Wilson Amanda , Cook Stephanie , Duan Zhizhou , Peng Ke , Hu Zhishan , Ou Jianjun , Duan Suqian , Yang Yuan , Ge Jiayu , Wang Hongyan , Chen Li , Zhao Kaihong , Chen Runsen 
Published: February 2020

Abstract

Background
The aim of this study was to investigate the mechanisms of Internet gaming disorder (IGD) and the associated interaction effects of childhood trauma, depression and anxiety in college students.

Methods
Participants were enrolled full-time as freshmen at a University in the Hunan province, China. All participants reported their socio-demographic characteristics and undertook a standardized assessment on childhood trauma, anxiety, depression and IGD. The effect of childhood trauma on university students' internet gaming behaviour mediated by anxiety and depression was analysed using structural equation modelling (SEM) using R 3.6.1.

Results
In total, 922 freshmen participated in the study, with an approximately even male-to-female ratio. A mediation model with anxiety and depression as the mediators between childhood trauma and internet gaming behaviour allowing anxiety and depression to be correlated was tested using SEM. The SEM analysis revealed that a standardised total effect of childhood trauma on Internet gaming was 0.18, (Z = 5.60, 95% CI [0.02, 0.05], P < 0.001), with the direct effects of childhood trauma on Internet gaming being 0.11 (Z = 3.41, 95% CI [0.01, 0.03], P = 0.001), and the indirect effects being 0.02 (Z = 2.32, 95% CI [0.00, 0.01], P = 0.020) in the pathway of childhood trauma-depression-internet gaming; and 0.05 (Z = 3.67, 95% CI [0.00, 0.02], P < 0.001) in the pathway of childhood trauma-anxiety-Internet gaming. In addition, the two mediators anxiety and depression were significantly correlated (r = 0.50, Z = 13.54, 95% CI [3.50, 5.05], P < 0.001).

Conclusions
The study revealed that childhood trauma had a significant impact on adolescents' Internet gaming behaviours among college students. Anxiety and depression both significantly mediated the relationship between childhood trauma and internet gaming and augmented its negative influence. Discussion of the need to understand the subtypes of childhood traumatic experience in relationship to addictive behaviours is included.
Gaps in the Management of Depression Symptoms Following Cancer Diagnosis: A Population-Based Analysis of Prospective Patient-Reported Outcomes
Authors: Hallet Julie , Davis Laura E. , Isenberg-Grzeda Elie , Mahar Alyson L. , Zhao Haoyu , Zuk Victoria , Moody Lesley , Coburn Natalie G. 
Published: February 2020

Abstract

Background
One of the most common psychological morbidities of cancer is depression. Routine depression symptoms screening (DSS) is recommended, but its ability to lead to psychosocial interventions in clinical practice is limited. We examined the use of and factors associated with psychosocial interventions for positive DSS following cancer diagnosis.

Materials and Methods
We conducted a population-based cohort study of patients with diagnoses from 2010 to 2017 who reported ≥1 patient-reported Edmonton Symptom Assessment System (ESAS) score. Positive DSS was defined as ESAS ≥2 out of 10 for the depression item within 6 months of diagnosis. Outcomes were psychosocial interventions around the time of positive DSS: palliative care assessment, psychiatry/psychology assessment, social work referral, and antidepressant therapy (in patients ≥65 years of age with universal drug coverage). We examined reduction in depression symptom score (≥1 point) following intervention. Modified Poisson regression examined factors associated with interventions.

Results
Of 142,270 patients, 65,424 (46.0%) reported positive DSS at a median of 66 days (interquartile range: 34–105) after diagnosis. Of those with depression symptoms, 17.1% received palliative assessment, 1.7% psychiatry/psychology assessment, 8.4% social work referral, and 4.3% antidepressant therapy. Depression symptom score decreased in 67.2% who received palliative assessment, 63.7% with psychiatry/psychology assessment, 67.3% with social work referral, and 71.4% with antidepressant therapy. On multivariable analysis, patients with older age, rural residence, lowest income quintile, and genitourinary or oropharyngeal cancer were more likely to not receive intervention other than palliative care.

Conclusion
The proportion of patients reporting positive DSS after cancer diagnosis receiving psychosocial intervention is low. We identified patients vulnerable to not receiving interventions, who may benefit from additional support. These data represent a call to action to modify practice and optimize the usefulness of systematic symptom screening.

Implications for Practice
Patient-reported depression symptoms screening should be followed by targeted interventions to improve symptoms and patient-centered management.