bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium Complexes of Corroles and Sapphyrins
Authors: Chen Qiu‐Cheng , Fridman Natalia , Diskin‐Posner Yael , Gross Zeev 
Published: June 2020

AbstractPalladium complexes of corrole and sapphyrin were prepared in high yield and fully characterized. The corrole provides a tetradentate/trianionic square planar coordination sphere for PdII, charge balanced by pyridinium. Both one and two PdII ions may be accommodated by the pentapyrrolic skeleton of the sapphyrin, and in each case the macrocycle acts as bidentate/monoanionic ligand and the inner‐sphere square planar geometry is completed by allyl anions coordinated in an η3 fashion. NMR spectroscopy and X‐ray crystallography data analyses uncovered the presence of interesting stereoisomers due to the flexibility of the ally ligands and also the pyrrole ring(s) that is/are not involved in metal binding.
Pericardial fat volume and coronary atherosclerotic markers among body mass index groups
Authors: Hassan Mohammed Bader , Nafakhi Hussein , Al‐Mosawi Abdulameer A. 
Published: June 2020

AbstractBackgroundIncreased pericardial fat volume (PFV) is associated with coronary atherosclerosis burden independent of body mass index (BMI) in many clinical studies. However, the association of PFV with markers of coronary atherosclerosis has not yet been assessed by dividing the patients according to BMI categories.HypothesisTo assess the association of PFV measured by multi‐detector CT (MDCT) angiography with coronary atherosclerotic markers (coronary artery calcium score [CAC], plaque type, and luminal stenosis) among BMI categories.MethodsA total of 496 patients with suspected coronary artery disease who underwent 64‐slice MDCT angiography examination were enrolled. Patients divided into obese, overweight, and normal weight groups according to BMI degree.ResultsPFV showed a significant association with CAC, non‐calcified coronary plaque, and significant coronary stenosis in obese group. After adjusting for cardiac risk factors, the association of PFV with the non‐calcified coronary plaque and significant coronary stenosis persisted. There was a significant association between PFV with CAC and significant coronary stenosis in normal weight group. The association between PFV with CAC and significant coronary stenosis in normal weight was persisted afar adjusting for cardiac risk factors. No significant association was noted between PFV with coronary plaque type in normal weight group. There was no significant independent association between PFV with coronary atherosclerotic markers in overweight group.ConclusionsIncreased PFV was associated with advanced stage atherosclerosis in normal weight group, while increased PFV was associated with non‐calcified plaque in obese. These results highlight the differential relationship of PFV with coronary atherosclerotic markers among BMI categories.
Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells
Authors: Hyeraci Mariafrancesca , Colalillo Marialuigia , Labella Luca , Marchetti Fabio , Samaritani Simona , Scalcon Valeria , Rigobello Maria Pia , Dalla Via Lisa 
Published: June 2020

AbstractPlatinum(II) complexes of the type [Pt(Cl)(PPh3){(κ2‐N,O)‐(1{C(R)=N(OH)‐2(O)C6H4})}] with R=Me, H, (1 and 2) were synthesized and characterized. Single‐crystal X‐ray diffraction confirmed the proposed (SP4‐3) configuration for 1. Study of the antiproliferative activity, performed on a panel of human tumor cell lines and on mesothelial cells, highlighted complex 2 as the more effective. In particular, it showed a remarkable cytotoxicity in ovarian carcinoma cells (A2780) and interestingly, a significant antiproliferative effect on cisplatin resistant cells (A2780cis). Investigation into the intracellular mechanism of action demonstrated that 2 had a lower ability to platinate DNA than did cisplatin, which was taken as reference, and a notably higher uptake in resistant cells. A significant accumulation in mitochondria, along with the ability to induce concentration‐dependent mitochondrial membrane depolarization and intracellular reactive oxygen species production, allowed us to propose a mitochondrion‐mediated pathway as responsible for the interesting cytotoxic profile of complex 2.
Privacy‐aware cloud ecosystems: Architecture and performance
Authors: Barati Masoud , Rana Omer 
Published: June 2020

SummaryWith an increasing number of cloud providers offering services made use of by both individual users and other providers, there is a realization that service provision now involves an “ecosystem” of providers. Some providers may be directly visible to a user, while others may be contributors to composite services and not directly known to the user—as only the provider offering the composite service is visible. Such services may include: domain specific services (eg, simulation), advertising services, or profiling/analytics services. Understanding the impact on data privacy of a user for such a composite service remains a challenge, and providing transparency (and obtaining user consent for data use) remains a key requirement of the European General Data Protection Regulation (GDPR). An architecture that makes use of blockchains and smart contracts is proposed that addresses this requirement. An implementation of the architecture is used to demonstrate how access control can be managed and audited. The scalability and cost of undertaking access control, as the number of actors (both service providers and “voters”) increases, is also described. The proposed approach can be used to support service aggregation across both private and public clouds.
Impact ofCSRand environmental triggers on employee green behavior: The mediating effect of employeewell‐being
Authors: Ahmed Mansoora , Zehou Sun , Raza Syed Ali , Qureshi Muhammad Asif , Yousufi Sara Qamar 
Published: June 2020

AbstractThis article explores the influence of corporate social responsibility (CSR) and three green triggers of environment (awareness, concern, and knowledge) on employee well‐being and green behavior. The study engages the stimulus–organism–responsemodel for testing the association between CSR and well‐being of employees that leads to employee green behavior. Furthermore, social exchange theory has been utilized to describe the association between well‐being and green behavior of employees. Data have been gathered through questionnaire from 509 employees working in guest‐service hotels of Pakistan. Structural equation modeling has been used to test the hypotheses. Findings show that CSR, environmental concern, and knowledge have positive effect on employee well‐being, whereas environmental awareness has positive but insignificant effect on employee well‐being. Furthermore, environmental concern, knowledge, and well‐being have a positive influence on green behavior, whereas CSR and environmental knowledge have a positive but insignificant effect. Moreover, well‐being fully mediates the relationship between CSR and green behavior and between environmental awareness and green behavior of employees. However, a partial mediation was observed between environmental concern and green behavior. The findings also indicate that no mediation was found between environmental knowledge and employee green behavior. The findings suggest that the hotel managers should invest to improve employee's awareness regarding green behavior by conducting environmental training for cultivating environmental knowledge and awareness. Moreover, CSR activities should be performed for attaining competitive edge and maintaining a balance between progress and sustainability of environment.
Genotyping‐in‐Thousands by sequencing reveals marked population structure in Western Rattlesnakes to inform conservation status
Authors: Schmidt Danielle A. , Govindarajulu Purnima , Larsen Karl W. , Russello Michael A. 
Published: June 2020

AbstractDelineation of units below the species level is critical for prioritizing conservation actions for species at‐risk. Genetic studies play an important role in characterizing patterns of population connectivity and diversity to inform the designation of conservation units, especially for populations that are geographically isolated. The northernmost range margin of Western Rattlesnakes (Crotalus oreganus) occurs in British Columbia, Canada, where it is federally classified as threatened and restricted to five geographic regions. In these areas, Western Rattlesnakes hibernate (den) communally, raising questions about connectivity within and between den complexes. At present, Western Rattlesnake conservation efforts are hindered by a complete lack of information on genetic structure and degree of isolation at multiple scales, from the den to the regional level. To fill this knowledge gap, we used Genotyping‐in‐Thousands by sequencing (GT‐seq) to genotype an optimized panel of 362 single nucleotide polymorphisms (SNPs) from individual samples (n = 461) collected across the snake's distribution in western Canada and neighboring Washington (USA). Hierarchical STRUCTURE analyses found evidence for population structure within and among the five geographic regions in BC, as well as in Washington. Within these regions, 11 genetically distinct complexes of dens were identified, with some regions having multiple complexes. No significant pattern of isolation‐by‐distance and generally low levels of migration were detected among den complexes across regions. Additionally, snakes within dens generally were more related than those among den complexes within a region, indicating limited movement. Overall, our results suggest that the single, recognized designatable unit for Western Rattlesnakes in Canada should be re‐assessed to proactively focus conservation efforts on preserving total genetic variation detected range‐wide. More broadly, our study demonstrates a novel application of GT‐seq for investigating patterns of diversity in wild populations at multiple scales to better inform conservation management.
Ribbonized sap flow: an emerging technology for the integration of sap flow sensor components onto a single platform
Authors: Jones Taylor S. , Winbourne Joy B. , Hutyra Lucy R. 
Published: June 2020

AbstractTrees play an important role in both the water and carbon cycles. Sensors that measure the flow rate of sap in individual trees provide critical insight into water use dynamics, and these data are vital for the understanding of ecosystem functions. Current sap flux sensors typically require the installation of multiple needle‐like probes into the sapwood of the tree. Despite the scientific value of high‐density measurements, the high cost and complexity of existing methods prevents the deployment of large networks of sensors. This study presents a new sap flow sensor design where all sensor components are on a single integrated circuit board (ribbon) thereby reducing cost and complexity. This system also eliminates misalignment errors, which are a problem inherent in some sap flow sensor designs. The new ribbonized sap flow (RSF) sensor was compared to gravimetric measurements of water flow to quantify the accuracy of the method and the tree wounding response. In a pair of field experiments, we tested the general performance of the sensor design over a growing season, and among several tree species. The laboratory calibration showed that the RSF sensor has similar accuracy and wounding response as traditional three‐probe designs. At a flow rate of 15 cm/h, the sensor underreported rates by 68% with a 19‐d wounding response, compared to other sensor designs, which underreport rates by 20–60%. Collectively, our field experiments show that the RSF sensor can produce reliable field data in a variety of species across full growing seasons. The RSF sensor platform is compact, robust, and versatile. Ribbonized sap flow sensors can be quickly and easily manufactured at low cost, which makes them ideal for the dense network of observations needed for the study of complex forest ecosystems and their response to global change.
Utility of routine evaluations for rejection in patients greater than 2 years after heart transplantation
Authors: Golbus Jessica R. , Konerman Matthew C. , Aaronson Keith D. 
Published: June 2020

AbstractAimsGuidelines support routine surveillance testing for rejection for at least 5 years after heart transplant (HT). In patients greater than 2 years post‐HT, we examined which clinical characteristics predict continuation of routine surveillance studies, outcomes following discontinuation of routine surveillance, and the cost‐effectiveness of different surveillance strategies.Methods and resultsWe retrospectively identified subjects older than 18 who underwent a first HT at our centre from 2007 to 2016 and who survived ≥760 days (n = 217) post‐HT. The clinical context surrounding all endomyocardial biopsies (EMBs) and gene expression profiles (GEPs) was reviewed to determine if studies were performed routinely or were triggered by a change in clinical status. Subjects were categorized as following a test‐based surveillance (n = 159) or a signs/symptoms surveillance (n = 53) strategy based on treating cardiologist intent to continue routine studies after the second post‐transplant year. A Markov model was constructed to compare two test‐based surveillance strategies to a baseline strategy of discontinuing routine studies. One thousand twenty studies were performed; 835 were routine. Significant rejection was absent in 99.0% of routine EMBs and 99.8% of routine GEPs. The treating cardiologist's practice duration, patient age, and immunosuppressive regimen predicted surveillance strategy. There were no differences in outcomes between groups. Routine surveillance EMBs cost more and were marginally less effective than a strategy of discontinuing routine studies after 2 years; surveillance GEPs had an incremental cost‐effectiveness ratio of $1.67 million/quality‐adjusted life‐year.ConclusionsAcute asymptomatic rejection is rare after the second post‐transplant year. Obtaining surveillance studies beyond the second post‐transplant year is not cost‐effective.
Characterization of pain syndromes in patients with neuromyelitis optica
Authors: Valerio Fernanda , Apostolos‐Pereira Samira L. , Sato Douglas Kazutoshi , Callegaro Dagoberto , Lucato Leandro Tavares , Barboza Victor Rosseto , Silva Valquiria A. , Galhardoni Ricardo , Rodrigues Antonia L. de Lima , Jacobsen Teixeira Manoel , Ciampi de Andrade Daniel 
Published: June 2020

AbstractBackgroundPain is common and refractory in spinal cord injury (SCI). Currently, most studies evaluated pain in male‐predominant traumatic‐SCI. Also, concomitant secondary pain syndromes and its temporal evolution were seldom reported.MethodsWe aimed to prospectively describe the main and secondary pain and its associated factors in inflammatory‐SCI evaluating neuromyelitis optica (NMO) patients. In‐remission NMO patients underwent neurological, imaging and autoantibody evaluations. Questionnaires detailing main and secondary pains, functional state, mood, catastrophizing, quality of life (QoL) and “non‐motor symptoms" were used at two time points.ResultsPain was present in 53 (73.6%) of the 72 patients included. At‐level neuropathic pain was the most common main pain syndrome, affecting 32 subjects (60.4% of those with pain). Over 70% (n = 38) of this cohort reported two pain syndromes. Those without pain were significantly younger (26.1 ± 12.7 y.o. in those without pain and 40.1 ± 12.5, 37.2 ± 11.4 y.o. in those whose main pain was neuropathic and non‐neuropathic, respectively,p = .001), and no differences in the inflammatory status were observed between groups. On follow‐up, one‐fifth (n = 11) had a different main pain syndrome from the first visit. Pain impacted QoL as much as disability and motor strength.ConclusionPain is a prevalent and disabling non‐motor symptom in NMO‐SCI. Most patients experience more than one pain syndrome which can change in time even in the absence of clinical relapse. Age of the inflammatory‐SCI was a major determinant of pain. Acknowledging temporal changes and multiplicity of pain syndromes in NMO‐SCI may give insights into more precise designs of clinical trials and general management of pain in SCI.SignificanceIn this longitudinal study with NMO‐related SCI, pain affected almost three‐quarters of patients with NMO. Over 70% have more than one pain syndrome and at‐level neuropathic pain is the most common type of pain syndrome. Patients without pain were significantly younger but had the same burden of inflammatory lesions than those with pain. During follow‐up, up to one fifth of patients presented with changes in the main pain syndromes, which can occur even in the absence of clinical activity of the inflammatory disease. In this cohort, Pain affected quality of life as much as disability or motor strength.
Clinoptilolite‐based Conductometric Sensors for Detection of Ammonium in Aqueous Solutions
Authors: Saiapina Olga , Vronska Yelyzaveta , Dzyadevych Sergei , Jaffrezic‐Renault Nicole 
Published: June 2020

AbstractNew clinoptilolite‐based conductometric sensors were developed and optimized for selective detection of ammonium in the buffered aqueous solutions. The sensors’ selective elements were prepared by subsequent drop‐casting of zeolite and Nafion on the gold electrode surface. Electrochemical impedance spectroscopy and differential conductometry were used to investigate the sensor performance. As determined in the phosphate buffer solution, the detection limit of the sensors was 30 μM and the linear range 0–1.5 mM. The developed sensors were featured with a simple preparation procedure, high selectivity to
, and storage stability for not less than 126 days.
Voltammetric Determination of 5‐Aminoquinoline at Carbon Film Electrode and Carbon and Gold Screen Printed Electrodes – A Comparative Study
Authors: Jiránek Ivan , Barek Jiří , Matysik Frank‐Michael 
Published: June 2020

AbstractAminoquinolines are widely used as antimalarial drugs and thus there is an ever increasing demand for their determination. In this paper, non‐traditional carbon film electrode developed in our laboratory (CFE) with easily replaceable carbon film was used for the determination of 5‐aminoquinoline (5‐AQ) and compared with well‐established commercially available carbon screen printed electrode (CSPE) and gold screen printed electrode (AuSPE). Electrochemical behavior of 5‐AQ was characterized by cyclic and differential pulse voltammetry. Differences in electrochemical behavior of 5‐AQ at different electrodes were evaluated. Determination of 5‐AQ was carried out by differential pulse, square wave, and direct current voltammetry. Practical applicability of the method was verified by direct determination of 5‐AQ in model samples of drinking and river water. Achieved limits of quantitation were in submicromolar concentrations. It was found out that novel CFE in terms of overall performance is in most aspects superior to routinely used commercially available CSPE and AuSPE.
Selection of aptamers targeted to food‐borne pathogenic bacteria Vibrio parahaemolyticus
Authors: Wang Lan , Lyu Shuxia , Gu Ganyu , Bolten Samantha 
Published: June 2020

AbstractVibrio parahaemolyticus (Vp) is a common marine halophilic food‐borne pathogen, mainly found in seafood and food with a high salt content. Gastrointestinal reactions such as diarrhea, headache, vomiting, nausea, and abdominal cramps may occur after eating food infected with Vp. This study aimed to screen for high‐affinity aptamers that specifically recognize Vp. A high‐affinity modified aptamer screening kit was used to rapidly screen aptamers of the food‐borne Vp. The first round of screening involved release of target aptamers from the microspheres. The "false‐positive" aptamers were eliminated after specific binding to and elution of Vp in the second round. The second round of screening of the aptamers involved polymerase chain reaction (PCR), and the abundance of a sequence was determined using next‐generation sequencing. Nine high‐affinity aptamer sequences were obtained, and the first eight modified aptamer sequences were derived using a cloud‐based intelligent software of the American AM Biotech Co. Escherichia coli (E. coli) was used as a control, and aptamer ID 12 with the highest affinity for Vp was selected using real‐time PCR. According to the principle of color change caused by nano‐gold condensing under salt induction, Salmonella, Listeria monocytogenes (L. monocytogenes), and E. coli were used as counter‐screening bacteria, and the aptamer ID12 was combined with nano‐gold. The results showed that aptamer ID12 has strong specificity for Vp. Based on these findings, this study developed a simple, innovative, and rapid method for screening Vp aptamers.
Oil jump risk
Authors: Ebrahimi Nima , Pirrong Craig 
Published: June 2020

AbstractThe risk premium associated with large upside jumps in oil market is a significant driver of the cross‐section of stock returns from 1986 to 2014. In contrast to previous research, variance risk is priced only when we do not control for jumps. Upward jumps are priced in tight supply‐demand conditions but not in more abundant supply periods. There is some evidence that downward jumps are priced in abundant supply conditions but not in tight conditions. Innovations in risk neutral jumps have predictive power for important economic indicators, including notably consumption growth. This helps explain the pricing of jump risks.
Numerical thermal‐hydraulic performance investigations in turbulent curved channel flow with horseshoe baffles
Authors: AL‐Juhaishi Lafta F. M. , Mohd Ali Mas F. , Mohammad Hafidh H. , Ajeel Raheem K. 
Published: June 2020

AbstractA numerical work is performed to investigate the thermal‐hydraulic performance in a curved channel of a journal bearing equipped with oblique horseshoe baffles. Water, a working fluid, is passed through the curved channel at a constant temperature condition of 358 K. The effects of different parameters of baffles, that is, attack angle (α = 45°, 60°, and 90°) and the number of baffles (NB = 9 and 13 baffles), are examined. Influences of design parameters on heat transfer and friction performances are studied and displayed in terms of the Nusselt number, the friction factor, the Nusselt number enhancement ratio, and the thermal‐hydraulic performance factor (THPF). The numerical simulations present the flow structures of the tested channel in terms of velocity, isotherms, turbulent kinetic energy, and vorticity contours. The numerical results reveal that the adopted geometry of the curved channel with baffles yields a significant enhancement of heat transfer rate over the plain channel (without baffles), which is approximately 2.5 to 3.8 times. Also, the results show that the best condition to achieve maximum heat transfer is at angle α = 90°, NB = 13, and Re = 5000, compared with other conditions. Furthermore, the maximum THPF of the curved channel using baffles is 4.4 at the same condition. The results confirmed that the geometry of the baffles inside the curved channel has a remarkable impact on heat transfer improvement, accompanied by a reasonable increase in friction losses.