bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommender systems in the healthcare domain: state-of-the-art and research issues
Authors: Tran Thi Ngoc Trang , Felfernig Alexander , Trattner Christoph , Holzinger Andreas 
Published: December 2020

AbstractNowadays, a vast amount of clinical data scattered across different sites on the Internet hinders users from finding helpful information for their well-being improvement. Besides, the overload of medical information (e.g., on drugs, medical tests, and treatment suggestions) have brought many difficulties to medical professionals in making patient-oriented decisions. These issues raise the need to apply recommender systems in the healthcare domain to help both, end-users and medical professionals, make more efficient and accurate health-related decisions. In this article, we provide a systematic overview of existing research on healthcare recommender systems. Different from existing related overview papers, our article provides insights into recommendation scenarios and recommendation approaches. Examples thereof are food recommendation, drug recommendation, health status prediction, healthcare service recommendation, and healthcare professional recommendation. Additionally, we develop working examples to give a deep understanding of recommendation algorithms. Finally, we discuss challenges concerning the development of healthcare recommender systems in the future.
Forecasting the future of library and information science and its sub-fields
Authors: Taşkın Zehra 
Published: December 2020

AbstractForecasting is one of the methods applied in many studies in the library and information science (LIS) field for numerous purposes, from making predictions of the next Nobel laureates to potential technological developments. This study sought to draw a picture for the future of the LIS field and its sub-fields by analysing 97 years of publication and citation patterns. The core Web of Science indexes were used as the data source, and 123,742 articles were examined in-depth for time series analysis. The social network analysis method was used for sub-field classification. The field was divided into four sub-fields: (1) librarianship and law librarianship, (2) health information in LIS, (3) scientometrics and information retrieval and (4) management and information systems. The results of the study show that the LIS sub-fields are completely different from each other in terms of their publication and citation patterns, and all the sub-fields have different dynamics. Furthermore, the number of publications, references and citations will increase significantly in the future. It is expected that more scholars will work together. The future subjects of the LIS field show astonishing diversity from fake news to predatory journals, open government, e-learning and electronic health records. However, the findings prove that publish or perish culture will shape the field. Therefore, it is important to go beyond numbers. It can only be achieved by understanding publication and citation patterns of the field and developing research policies accordingly.
Citation inequality and the Journal Impact Factor: median, mean, (does it) matter?
Authors: Kiesslich Tobias , Beyreis Marlena , Zimmermann Georg , Traweger Andreas 
Published: December 2020

AbstractSkewed citation distribution is a major limitation of the Journal Impact Factor (JIF) representing an outlier-sensitive mean citation value per journal The present study focuses primarily on this phenomenon in the medical literature by investigating a total ofn = 982 journals from two medical categories of the Journal Citation Report (JCR). In addition, the three highest-ranking journals from each JCR category were included in order to extend the analyses to non-medical journals. For the journals in these cohorts, the citation data (2018) of articles published in 2016 and 2017 classified as citable items (CI) were analysed using various descriptive approaches including e.g. the skewness, the Gini coefficient, and, the percentage of CI contributing 50% or 90% of the journal’s citations. All of these measures clearly indicated an unequal, skewed distribution with highly-cited articles as outliers. The %CI contributing 50% or 90% of the journal’s citations was in agreement with previously published studies with median values of 13–18% CI or 44–60% CI generating 50 or 90% of the journal’s citations, respectively. Replacing the mean citation values (corresponding to the JIF) with the median to represent the central tendency of the citation distributions resulted in markedly lower numerical values ranging from − 30 to − 50%. Up to 39% of journals showed a median citation number of zero in one medical journal category. For the two medical cohorts, median-based journal ranking was similar to mean-based ranking although the number of possible rank positions was reduced to 13. Correlation of mean citations with the measures of citation inequality indicated that the unequal distribution of citations per journal is more prominent and, thus, relevant for journals with lower citation rates. By using various indicators in parallel and the hitherto probably largest journal sample, the present study provides comprehensive up-to-date results on the prevalence, extent and consequences of citation inequality across medical and all-category journals listed in the JCR.
An update on the pathogenesis of Hashimoto’s thyroiditis
Authors: Weetman A. P. 
Published: December 2020

AbstractIt is 70 years since Noel Rose embarked on his pioneering studies that lead to the discovery of autoimmune thyroiditis and the elucidation of Hashimoto’s thyroiditis. This short review to honour his passing focuses on the developments in our understanding of the causes and pathogenesis of HT over the last five years. Recent genetic studies have reported heritability estimates for HT and associated diseases for the first time, and emphasised the complexity of the genetic factors involved, including monogenic forms of HT. Environmental factors continue to be elucidated, especially as a side effect of drugs which modulate the immune system therapeutically. Regarding pathogenetic mechanisms, multiple cytokine networks have been identified which involve the thyroid cells in a circuit of escalating proinflammatory effects, such as the expression of inflammasome components, and an array of different defects in T regulatory cells may underlie the loss of self-tolerance to thyroid autoantigens. Finally, a number of studies have revealed fresh insights into disease associations with HT which may have both pathological and clinical significance, the most intriguing of which is a possible direct role of the autoimmune process itself in causing some of the persistent symptoms reported by a minority of patients with levothyroxine-treated HT.
Barriers to the delivery of enteral nutrition in pediatric intensive care units
Authors: Alsohime Fahad , Assiry Ghadeer , AlSalman Munirah , Alabdulkareem Wejdan , Almuzini Hissah , Alyahya Malak , Allhidan Reema , Al-Eyadhy Ayman , Temsah Mohamad-Hani , Al Sarkhy Ahmed A. 
Published: December 2020

Background and Aim:
According to previously reported studies in the literature, a significant number of patients do not receive enteral nutrition in pediatric intensive care unit (PICU) because of avoidable barriers. Optimal nutrition is a fundamental goal in PICU. This study aims to identify the barriers of enteral nutrition in PICU.

Setting and Design:
A cross-sectional study of the results of a 25-item questionnaire-based survey distributed during the Annual International Critical Care Conference by the Saudi Critical Care Society.

Methods and material:
A 7-point Likert-type scale was used to rank the participants' responses, and the relative importance index (RII) approach was used to analyze the relative contribution of each indicator to its main theme.
The factor and parallel analysis methods were used to assess the factorial and unidimensionality of the enteral feeding barriers scale.

Results:
A total of 223 PICU healthcare workers from various intensive care settings responded to the survey. The top-three perceived barriers for commencing enteral feeding were due to the patient being hemodynamically unstable (M = 3.6 and SD = 1.70), delays and difficulties in obtaining small bowel access in patients not tolerating other types of enteral nutrition (M = 3.4 and SD = 1.52), or severe fluid restriction, particularly in postoperative cardiac surgery (M = 3.3 and SD = 1.59). The top perceived overall barriers to enteral feeding were the dietician-related issues (M = 3.3, SD = 1.32), barriers related to enteral feeding delivery (M = 3.16 and SD = 1.13), and medical practice-related (M = 3 and SD = 1.10) issues. The lowest reported overall barriers were the resource-related obstacles (M = 2.7 and SD = 1.26).

Conclusion:
Being hemodynamically unstable and other dietician-related reasons were the top overall barriers in commencing enteral feeding.
Accounting for the Distribution of Benefits and Costs in Benefit–Cost Analysis
Authors: Hammitt James K. 
Published: December 2020

AbstractBenefit–cost analysis (BCA) is often viewed as measuring the efficiency of a policy independent of the distribution of its consequences. The role of distributional effects on policy choice is disputed; either: (a) the policy that maximizes net benefits should be selected and distributional concerns should be addressed through other measures, such as tax and transfer programs or (b) BCA should be supplemented with distributional analysis and decision-makers should weigh efficiency and distribution in policy choice. The separation of efficiency and distribution is misleading. The measure of efficiency depends on the numéraire chosen for the analysis, whether monetary values or some other good (unless individuals have the same rates of substitution between them). The choice of numéraire is not neutral; it can affect the ranking of policies by calculated net benefits. Alternative evaluation methods, such as BCA using a different numéraire, weighted BCA, or a social welfare function (SWF), may better integrate concerns about distribution and efficiency. The most appropriate numéraire, distributional weights, or SWFs cannot be measured or statistically estimated; it is a normative choice.
Glacier albedo reduction and drought effects in the extratropical Andes, 1986–2020
Authors: Shaw Thomas E. , Ulloa Genesis , Farías-Barahona David , Fernandez Rodrigo , Lattus Jose M. , McPhee James 
Published: December 2020

AbstractSurface albedo typically dominates the mass balance of mountain glaciers, though long-term trends and patterns of glacier albedo are seldom explored. We calculated broadband shortwave albedo for glaciers in the central Chilean Andes (33–34°S) using end-of-summer Landsat scenes between 1986 and 2020. We found a high inter-annual variability of glacier-wide albedo that is largely a function of the glacier fractional snow-covered area and the total precipitation of the preceding hydrological year (up to 69% of the inter-annual variance explained). Under the 2010–2020 ‘Mega Drought’ period, the mean albedo, regionally averaged ranging from ~0.25–0.5, decreased by −0.05 on average relative to 1986–2009, with the greatest reduction occurring 3500–5000 m a.s.l. In 2020, differences relative to 1986–2009 were −0.14 on average as a result of near-complete absence of late summer snow cover and the driest hydrological year since the Landsat observation period began (~90% reduction of annual precipitation relative to the 1986–2009 period). We found statistically significant, negative trends in glacier ice albedo of up to −0.03 per decade, a trend that would have serious implications for the future water security of the region, because glacier ice melt acts to buffer streamflow shortages under severe drought conditions.
When Does Accommodation Work? Electoral Effects of Mainstream Left Position Taking on Immigration
Authors: Hjorth Frederik , Larsen Martin Vinæs 
Published: December 2020

AbstractIn many countries, right-wing populist parties have gained electoral support by attracting voters from mainstream left parties. This has prompted public and scholarly debate about whether mainstream left parties can regain political power by taking a more restrictive position on immigration, a so-called accommodation strategy. However, selection bias confounds observational estimates of the effectiveness of this strategy. This letter reports the results of a survey experiment conducted among Danish voters during a unique political situation in which the mainstream left party's position on immigration is ambiguous, enabling experimental manipulation of voters' perceptions of the party's position. The authors show that, consistent with spatial models of politics, accommodation attracts anti-immigration voters and repels pro-immigration voters. Because repelled voters defect to other left parties, while attracted voters come from right parties, accommodation increases overall support for parties that support a mainstream left government. The results demonstrate that in some contexts, accommodation can improve the political prospects of the mainstream left.
Integration of resistant variety and biological agent to control tomato leaf miner,Tuta absoluta(Meyrick), under greenhouse conditions
Authors: Saeidi Zarir , Raeesi Mehdi 
Published: December 2020

AbstractTuta absoluta(Meyrick) is considered as a major pest of tomato worldwide that causes significant losses in the crop production. This study aimed to evaluate integration of two effective and environmentally safe methods (host plant resistant and biological control) for sustainable management of the pest under greenhouse conditions. The experiment was conducted based on the factorial design with ten replicates under greenhouse conditions (22 ± 3°C, 50 ± 10 RH and 14 L:10 D photoperiod). Infestation toT. absolutawas conducted at the first-flowering stage of the plants by introducing a pair of newly emerged adults (one female and one male) per plant. Ten days later, the biological agent,Trichogramma brassicae, was released on the treatments by hanging a card contained 50 parasitized eggs in each replicate. Observation was performed weekly on ratio of infested leaves per plant (%), number of larvae/plant, number of mines/leaf and ratio of infested fruits/plant (%). Results indicated that the susceptible variety alone (Izmir) supported the highest ratio of infested leaves (42.92 ± 1.95%), number of larvae/plant (12.86 ± 0.71), number of mines/leaf (1.29 ± 0.07) and infested fruits/plant (18.8 ± 1.10%), whereas the lowest (6.12 ± 0.42%, 1.85 ± 0.13, 0.18 ± 0.02 and 0.12 ± 0.06%, respectively) were observed in combined resistant variety (Cherry) and parasitoid released treatment. Integration of these methods not only decreases damage caused on tomato leaflets and fruits, but also reduces insecticide applications which are adversely impact human health and environment.
Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
Authors: Dubois Christophe J. , Fawcett-Patel Jessica , Katzman Paul A. , Liu Siqiong June 
Published: December 2020

AbstractEndocannabinoids retrogradely regulate synaptic transmission and their abundance is controlled by the fine balance between endocannabinoid synthesis and degradation. While the common assumption is that “on-demand” release determines endocannabinoid signaling, their rapid degradation is expected to control the temporal profile of endocannabinoid action and may impact neuronal signaling. Here we show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum. Learning induced a lasting increase in GABA release and this was responsible for driving the change in endocannabinoid degradation. Conversely, Gq-DREADD activation of cerebellar Purkinje cells enhanced endocannabinoid signaling and impaired memory consolidation. Our findings identify a previously unappreciated reciprocal interaction between GABA and the endocannabinoid system in which GABA signaling accelerates endocannabinoid degradation, and triggers a form of learning-induced metaplasticity.
Metavinculin modulates force transduction in cell adhesion sites
Authors: Kanoldt Verena , Kluger Carleen , Barz Christiane , Schweizer Anna-Lena , Ramanujam Deepak , Windgasse Lukas , Engelhardt Stefan , Chrostek-Grashoff Anna , Grashoff Carsten 
Published: December 2020

AbstractVinculin is a ubiquitously expressed protein, crucial for the regulation of force transduction in cells. Muscle cells express a vinculin splice-isoform called metavinculin, which has been associated with cardiomyopathies. However, the molecular function of metavinculin has remained unclear and its role for heart muscle disorders undefined. Here, we have employed a set of piconewton-sensitive tension sensors to probe metavinculin mechanics in cells. Our experiments reveal that metavinculin bears higher molecular forces but is less frequently engaged as compared to vinculin, leading to altered force propagation in cell adhesions. In addition, we have generated knockout mice to investigate the consequences of metavinculin loss in vivo. Unexpectedly, these animals display an unaltered tissue response in a cardiac hypertrophy model. Together, the data reveal that the transduction of cell adhesion forces is modulated by expression of metavinculin, yet its role for heart muscle function seems more subtle than previously thought.
Spin–valley Hall phenomena driven by Van Hove singularities in blistered graphene
Authors: Farooq M. Umar , Hashmi Arqum , Ono Tomoya , Huang Li 
Published: December 2020

AbstractUsing first-principles calculations, we investigate the possibility of realizing valley Hall effects (VHE) in blistered graphene sheets. We show that the Van Hove singularities (VHS) induced by structural deformations can give rise to interesting spin–valley Hall phenomena. The broken degeneracy of spin degree of freedom results in spin-filtered VH states and the valley conductivity have a Hall plateau of ±e2/2h, while the blistered structures with time-reversal symmetry show the VHE with the opposite sign of $$\sigma _{xy}^{K/K^{\prime}}$$

σ

x
y

K
/

K

′

(e2/2h) in the two valleys. Remarkably, these results show that the distinguishable chiral valley pseudospin state can occur even in the presence of VHS induced spin splitting. The robust chiral spin–momentum textures in both massless and massive Dirac cones of the blistered systems indicate significant suppression of carrier back-scattering. Our study provides a different approach to realize spin-filtered and spin-valley contrasting Hall effects in graphene-based devices without any external field.
A combined microphysiological-computational omics approach in dietary protein evaluation
Authors: Jochems Paulus G. M. , Keusters Willem R. , America Antoine H. P. , Rietveld Pascale C. S. , Bastiaan-Net Shanna , Ariëns Renata M. C. , Tomassen Monic M. M. , Lewis Fraser , Li Yang , Westphal Koen G. C. , Garssen Johan , Wichers Harry J. , van Bergenhenegouwen Jeroen , Masereeuw Rosalinde 
Published: December 2020

AbstractFood security is under increased pressure due to the ever-growing world population. To tackle this, alternative protein sources need to be evaluated for nutritional value, which requires information on digesta peptide composition in comparison to established protein sources and coupling to biological parameters. Here, a combined experimental and computational approach is presented, which compared seventeen protein sources with cow’s whey protein concentrate (WPC) as the benchmark. In vitro digestion of proteins was followed by proteomics analysis and statistical model-based clustering. Information on digesta peptide composition resulted in 3 cluster groups, primarily driven by the peptide overlap with the benchmark protein WPC. Functional protein data was then incorporated in the computational model after evaluating the effects of eighteen protein digests on intestinal barrier integrity, viability, brush border enzyme activity, and immune parameters using a bioengineered intestine as microphysiological gut system. This resulted in 6 cluster groups. Biological clustering was driven by viability, brush border enzyme activity, and significant differences in immune parameters. Finally, a combination of proteomic and biological efficacy data resulted in 5 clusters groups, driven by a combination of digesta peptide composition and biological effects. The key finding of our holistic approach is that protein source (animal, plant or alternative derived) is not a driving force behind the delivery of bioactive peptides and their biological efficacy.
An open-source, end-to-end workflow for multidimensional photoemission spectroscopy
Authors: Xian R. Patrick , Acremann Yves , Agustsson Steinn Y. , Dendzik Maciej , Bühlmann Kevin , Curcio Davide , Kutnyakhov Dmytro , Pressacco Federico , Heber Michael , Dong Shuo , Pincelli Tommaso , Demsar Jure , Wurth Wilfried , Hofmann Philip , Wolf Martin , Scheidgen Markus , Rettig Laurenz , Ernstorfer Ralph 
Published: December 2020

AbstractCharacterization of the electronic band structure of solid state materials is routinely performed using photoemission spectroscopy. Recent advancements in short-wavelength light sources and electron detectors give rise to multidimensional photoemission spectroscopy, allowing parallel measurements of the electron spectral function simultaneously in energy, two momentum components and additional physical parameters with single-event detection capability. Efficient processing of the photoelectron event streams at a rate of up to tens of megabytes per second will enable rapid band mapping for materials characterization. We describe an open-source workflow that allows user interaction with billion-count single-electron events in photoemission band mapping experiments, compatible with beamlines at 3rdand 4rdgeneration light sources and table-top laser-based setups. The workflow offers an end-to-end recipe from distributed operations on single-event data to structured formats for downstream scientific tasks and storage to materials science database integration. Both the workflow and processed data can be archived for reuse, providing the infrastructure for documenting the provenance and lineage of photoemission data for future high-throughput experiments.
Lubricant film formation in rough surface non-conformal conjunctions subjected to GPa pressures and high slide-to-roll ratios
Authors: Hansen Jonny , Björling Marcus , Larsson Roland 
Published: December 2020

AbstractA ball-on-disc machine was employed in a highly idealised setting to study the interplay between oil film formation and surface irregularities in single-sided rough elasto-hydrodynamic lubricated (EHL) conjunctions. The tests were operated under GPa pressures and high slide-to-roll ratios in a situation where the separating gap was smaller than the combined surface roughness height. Under the initial state of solid contact interference and with the operating conditions held fixed, surfaces were found to gradually conform such that a fully separating oil film of nanometre thickness eventually developed—a thin film lubrication state known as micro-EHL. Additionally, with a previously developed approach for 3D surface re-location analysis, we were able to very precisely specify the pertained nature of surface transformations, even at the asperity scale, by comparing the post-test surfaces to those in the virgin state. The surface roughness Sq was reduced by up to 17% after running-in, while the speed required for full film EHL was reduced by a remarkable 90%. Hence, full film EHL is possible even in cases where the Λ-ratio falsely suggests boundary lubrication. This discrepancy was attributed to the way surfaces are deformed inside the contact, i.e., through the establishment of micro-EHL.