bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVIDStrategyCalculator: A software to assess testing- and quarantine strategies for incoming travelers, contact person management and de-isolation
Authors: van der Toorn Wiep , Oh Djin-Ye , von Kleist Max 
Published: November 2020

SummaryWhile large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals, and quarantine of exposed individuals remain central measures to contain the spread of SARS-CoV-2. Strategies that combine NPIs with innovative SARS-CoV-2 testing strategies may increase containment efficacy and help to shorten quarantine durations.We developed a user-friendly software-tool that implements a recently published stochastic within-host viral dynamics model that captures temporal attributes of the viral infection, such as test sensitivity, infectiousness and the occurrence of symptoms. Based on this model, the software allows to evaluate the efficacy of user-defined, arbitrary NPI and testing strategies in reducing the transmission potential in different contexts. The software thus enables decision makers to explore NPI strategies and perform hypothesis testing, e.g. with regards to the utilization of novel diagnostics or with regards to containing novel virus variants.
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold
Authors: Schweizer Nina , Haren Laurence , Viais Ricardo , Lacasa Cristina , Dutto Ilaria , Merdes Andreas , Lüders Jens 
Published: November 2020

AbstractCentriole biogenesis and maintenance are crucial for cells to generate cilia and assemble centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis and MTOC function both require the microtubule nucleator γ-tubulin ring complex (γTuRC). The widely accepted view is that γTuRC localizes to the pericentriolar material (PCM), where it nucleates microtubules. γTuRC has also been observed at centriolar regions that lack PCM, but the significance of these findings is unclear. Here we have used expansion microscopy to map spatially and functionally distinct sub-populations of centrosomal γTuRC including in the centriole lumen. Luminal localization is mediated by augmin and both complexes are linked to the centriole inner scaffold through POC5. Disruption of luminal localization impairs centriole stability and cilia assembly, defects that are also observed in γTuRC mutant fibroblasts derived from a patient suffering from microcephaly with chorioretinopathy. These results identify a novel, non-canonical role of augmin-γTuRC in the centriole lumen that is linked to human disease.
Dysglycemia is associated withMycobacterium tuberculosislineages in tuberculosis patients of North Lima - Peru
Authors: Lopez Kattya , Arriaga María B. , Aliaga Juan G. , Barreda Nadia N. , Sanabria Oswaldo M. , Huang Chuan-Chin , Zhang Zibiao , García-de-la-Guarda Ruth , Lecca Leonid , Calçada Carvalho Anna Cristina , Kritski Afrânio L. , Calderon Roger I. 
Published: November 2020

AbstractThis study was performed to investigate the role of dysglycemia on the genetic diversity ofMycobacterium tuberculosis(MTB) among pulmonary tuberculosis (TB) patients to build scientific evidence about the possible mechanisms of TB transmission. MTB isolates obtained of patients affected by pulmonary tuberculosis from health care facilities of North Lima - Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem repeats (MIRU-VNTR). Subsequently, clinical and epidemiological characteristics were associated with clustering, lineages and comorbid conditions. The analysis carried out 112 pulmonary TB patients from various health centers in North Lima, 17 (15%) had diabetes mellitus (DM) and 33 (29%) had pre-diabetes (PDM). Latin American-Mediterranean, Haarlem and Beijing were the most frequent MTB lineages found in those patients. Previous TB (adjusted odds ratio [aOR]=3.65; 95%CI: 1.32-17.81), age (aOR=1.12; 95%CI: 1.03-1.45) and Beijing lineage (aOR=3.53; 95%CI: 1.08-13.2) were associated with TB-DM comorbidity. Alcoholism (aOR=2.92; 95%CI: 1.10-8.28), age (aOR=1.05; 95%CI: 1.03-1.12) and Haarlem lineage (aOR=2.54; 95%CI: 1.04-6.51) were associated with TB-PDM comorbidity. Beijing and Haarlem lineages were independently associated with TB-DM and TB-PDM comorbidities, respectively. Although these findings may be surprising, we must be cautious to suggest that dysglycemia could be associated with a highly clustering and predisposition of MTB lineages related to a serious impact on the severity of TB disease, which requires further research.
Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets
Authors: Lee Jeong Seok , Koh June-Young , Yi Kijong , Kim Young-Il , Park Su-Jin , Kim Eun-Ha , Kim Se-Mi , Park Sung Ho , Ju Young Seok , Choi Young Ki , Park Su-Hyung 
Published: November 2020

AbstractAlthough the profile of immune cells changes during the natural course of SARS-CoV-2 inflection in human patients, few studies have used a longitudinal approach to reveal their dynamic features. Here, we performed single-cell RNA sequencing of bronchoalveolar lavage fluid cells longitudinally obtained from SARS-CoV-2-infected ferrets. Landscape analysis of the lung immune microenvironment showed dynamic changes in cell proportions and characteristics in uninfected control, at 2 days post-infection (dpi) (early stage of SARS-CoV-2 infection with peak viral titer), and 5 dpi (resolution phase). NK cells and CD8+T cells exhibited activated subclusters with interferon-stimulated features, which were peaked at 2 dpi. Intriguingly, macrophages were classified into 10 distinct subpopulations, and their relative proportions changed over the time. We observed prominent transcriptome changes among monocyte-derived infiltrating macrophages and differentiated M1/M2 macrophages, especially at 2 dpi. Moreover, trajectory analysis revealed gene expression changes from monocyte-derived infiltrating macrophages toward M1 or M2 macrophages and identified the distinct macrophage subpopulation that had rapidly undergone SARS-CoV-2-mediated activation of inflammatory responses. Finally, we found that different spectrums of M1 or M2 macrophages showed distinct patterns of gene modules downregulated by immune-modulatory drugs. Overall, these results elucidate fundamental aspects of the immune response dynamics provoked by SARS-CoV-2 infection.
HLA class I genotypes customize vaccination strategies in immune simulation to combat COVID-19
Authors: Huang Shouxiong , Tan Ming 
Published: November 2020

AbstractMemory CD8+T cells are associated with a better outcome in Coronavirus Disease 2019 (COVID-19) and recognized as promising vaccine targets against viral infections. This study determined the efficacy of population-dominant and infection-relevant human leukocyte antigens (HLA) class I proteins to present severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides through calculating binding affinities and simulating CD8+T cell responses. As a result, HLA class I proteins distinguished or shared various viral peptides derived from viruses. HLA class I supertypes clustered viral peptides through recognizing anchor and preferred residues. SARS-CoV-2 peptides overlapped significantly with SARS but minimally with common human coronaviruses. Immune simulation of CD8+T cell activation using predicted SARS-CoV-2 peptide antigens depended on high-affinity peptide binding, anchor residue interaction, and synergistic presentation of HLA class I proteins in individuals. Results demonstrated that multi-epitope vaccination, employing a strong binding affinity, viral adjuvants, and heterozygous HLA class I genes, induced potent immune responses. Therefore, optimal CD8+T cell responses can be achieved and customized contingent on HLA class I genotypes in human populations, supporting a precise vaccination strategy to combat COVID-19.
Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi- species biofilm formation
Authors: Guo Shuaiqi , Vance Tyler D.R. , Zahiri Hossein , Eves Robert , Stevens Corey , Hehemann Jan-Hendrik , Vidal-Melgosa Silvia , Davies Peter L. 
Published: November 2020

AbstractCarbohydrate recognition by lectins governs critical host-microbe interactions.MpPA14lectin is a domain of a 1.5-MDa adhesin responsible for a symbiotic bacterium-diatom interaction in Antarctica. Here we showMpPA14 binds various monosaccharides, with L-fucose and N-acetyl glucosamine being the strongest ligands (Kd~ 150 μM). High-resolution structures ofMpPA14 with 15 different sugars bound elucidated the molecular basis for the lectin’s apparent binding promiscuity but underlying selectivity.MpPA14 mediates strong Ca2+-dependent interactions with the 3, 4 diols of L-fucopyranose and glucopyranoses, and binds other sugars via their specific minor isomers. Thus,MpPA14 only binds polysaccharides like branched glucans and fucoidans with these free end-groups. Consistent with our findings, adhesion ofMpPA14 to diatom cells was selectively blocked by L-fucose, but not by N-acetyl galactosamine. WithMpPA14 lectin homologs present in adhesins of several pathogens, our work gives insight into an anti-adhesion strategy to block infection via ligand-based antagonists.
Representations of local spatial information in the human medial temporal lobe during memory-guided navigation
Authors: Wang Shao-Fang , Carr Valerie A. , Favila Serra E. , Bailenson Jeremy N. , Brown Thackery I. , Jiang Jiefeng , Wagner Anthony D. 
Published: November 2020

AbstractThe hippocampus (HC) and surrounding medial temporal lobe (MTL) cortical regions play a critical role in spatial navigation and episodic memory. However, it remains unclear how the interaction between the HC’s conjunctive coding and mnemonic differentiation contributes to neural representations of spatial environments. Multivariate functional magnetic resonance imaging (fMRI) analyses enable examination of how human HC and MTL cortical regions encode multidimensional spatial information to support memory-guided navigation. We combined high-resolution fMRI with a virtual navigation paradigm in which participants relied on memory of the environment to navigate to goal locations in two different virtual rooms. Within each room, participants were cued to navigate to four learned locations, each associated with one of two reward values. Pattern similarity analysis revealed that when participants successfully arrived at goal locations, activity patterns in HC and parahippocampal cortex (PHC) represented room-goal location conjunctions and activity patterns in HC subfields represented room-reward-location conjunctions. These results add to an emerging literature revealing hippocampal conjunctive representations during goal-directed behavior.
Effects of service authenticity, customer participation and customer-perceived service climate on customers' service evaluation
Authors: Bae Byung Ryul 
Published: November 2020

PurposeThe purpose of this study is to examine the effect of service authenticity, customer participation (CP) and customer-perceived service climate on customers' service evaluation within the context of smartphone repair services in South Korea. A conceptual model, including customer-perceived service climate, service authenticity, CP, service value and service satisfaction, was proposed and tested.Design/methodology/approachThe authors test the research model using a structural equation modeling approach (Amos) based on a mobile survey of 430 South Korean consumers. The authors design the research based on causal relationships and collect the data using the convenience sampling method.FindingsThe authors found that the independent variables (customer-perceived service climate, service authenticity and CP) have a positive effect on service value as well as service satisfaction. Further, service value has a mediating effect on the relationships between the independent variables and service satisfaction.Originality/valueThis is the first study to examine the effects of smartphone repair service on customers' evaluation. As the number of smartphone users increases, the results obtained from this study will provide important managerial implications for service managers.
The determinants of energy intensity in Indonesia
Authors: Rudenko Dmitry , Tanasov Georgii 
Published: November 2020

PurposeIndonesia is the fourth most populous country in the world, which has a strong effect on primary energy use and depletion of natural resources. This paper considers energy intensity (EI) defined as a measure of the amount of energy it takes to produce a dollar's worth of economic output. The purpose of the paper is to explore how different factors contributed to the decline in Indonesia's EI.Design/methodology/approachThe cointegration regression methodology is applied to explore the long-term nexus between EI and its factors in Indonesia during 1990–2016.FindingsResults show that domestic credit to the private sector, as well as the share of alternative energy, has a significant impact on the decline of EI in Indonesia.Research limitations/implicationsWe do not try to rule out other possible determinants of EI. We consider the determinants of EI using time series data, while an ideal analysis would be based on panel-level data. Another limitation is that the study covers only the small-time period from 1990 to 2016.Practical implicationsOur findings serve to aid the government and policymakers in prioritizing improvements in the sphere of energy policy. An important policy implication, regarding Indonesia, that arises from our study is that, for the country to be able to decrease its EI, it must be able to develop its financial market and zero-carbon energy sources, mainly geothermal energy with its huge potential.Originality/valueWe show that energy prices, financial development and the share of alternative energy sources contribute to EI decrease. Policy recommendations include geothermal and solar energy development as one of the most prospective sources of alternative energy in Indonesia.
ERIP: service quality model of management consulting projects
Authors: Veres Zoltan , Varga-Toldi Katalin 
Published: November 2020

Purpose
There is still no generally accepted quality model of consulting services. This is particularly the case for management consulting projects, where scope is often indefinite. The purpose of this paper is to identify the clients’ underlying utility preferences and their perceived quality dimensions.

Design/methodology/approach
The research is a qualitative data collection from 22 expert interviews performed in the financial service sector. Interviewees from the client-side were decision-makers from different hierarchical levels with considerable experience in working with consultants, while the consultant sample was obtained by selecting professionals with relevant project experience. The model development was based on the grounded theory.

Findings
Based on a content analysis of a 600-page transcript of interviews, it was found that customers construct their judgments on consulting service quality through five main attributes: consultants, client adaption, consulting process, deliverables and communication. Because of the strong overlaps of the attributes, four better separable quality dimensions – as a conceptual model – were identified: expertise, relations, involvement and performance.

Practical implications
Among managerial implications for consulting firms, support of buying organization in setting clear project objectives, flexibility in partnership and readiness for overperformance can be underlined.

Originality/value
There is little empirical research that focuses on the conceptualization of management consulting service quality from a client perspective. The value of the paper is the exploration of perceived service quality dimensions of management consulting projects and a consulting context-specific list of quality attributes.
Antecedents and consequences of supply chain resilience and reconfiguration: an empirical study in an emerging economy
Authors: Al Naimi Maryam , Faisal Mohd Nishat , Sobh Rana , Uddin S.M. Fatah 
Published: November 2020

PurposeThe purpose of this paper is twofold: to investigate the antecedents of resilience and to highlight the importance of resilience in achieving reconfiguration in supply chains.Design/methodology/approachThis paper draws on literature on supply chain resilience and collects data from 253 companies in Qatar to understand the influence of the antecedents of supply chain resilience and the impact of resilience on reconfiguration using partial least squares structural equation modeling.FindingsThe findings show that antecedents like risk management culture, agility and collaboration positively affect the supply chain resilience. Further, the study establishes that companies can leverage their supply chain resilience to reconfigure supply chain in case of disruptions.Practical implicationsThis study is important for supply chain managers in Qatar, as the country faced major disruption of supply chains in wake of the blockade imposed by its neighbors with which it had the only land route and maximum trade. The findings from this study should aid mangers in developing resilient supply chains.Originality/valueThis paper highlights the role of supply chain resilience in achieving reconfiguration. Further, novelty of the work reported in this paper lies in its context where supply chains recently faced actual disruptions.
Enhancing the role of facilities management in the fight against the COVID-19 (SARS-CoV-2) pandemic in developing countries’ public hospitals
Authors: Amos Daniel , Au-Yong Cheong Peng , Musa Zairul Nisham 
Published: November 2020

Purpose
This paper aims to present a review of the current COVID-19 pandemic with particular emphasis on developing countries in Africa. It aims to demonstrate how facilities management (FM) services delivery in public hospitals can be improved for the fight against the COVID-19 pandemic.

Design/methodology/approach
This paper embraces a review of current literature on COVID-19 and FM together with credible media updates. The paper critically synthesizes knowledge on the pandemic to position a technical view on how FM can be improved in the fight against the COVID-19 pandemic.

Findings
The COVID-19 pandemic presents unprecedented challenges and realities to the health-care system of most African countries. Despite the significant efforts being made by various governments, there appears to be a lack of a coherent and strategic FM plan to fight the pandemic. To create the necessary antivirus built environment, actionable and timely FM interventions are needed.

Research limitations/implications
The report herein is case guarded, based on the prevailing data and information as at the time of writing the paper. Nevertheless, the recommendations from the paper are useful for a worse future trajectory of the pandemic.

Practical implications
Knowledge of the proposed interventions will inform and assist health-care facilities managers in the fight against the COVID-19 pandemic.

Originality/value
The paper presents the first step towards encapsulating knowledge on FM and the COVID-19 pandemic. It sets forth recommendations that are useful for most developing countries’ public hospitals’ FM practices in the fight against this global pandemic. The authors intend to follow-up with future empirical studies for more objective assessments of FM and the COVID-19 pandemic.
The influence of consumer personality traits on mobile shopping intention
Authors: Camoiras-Rodriguez Zaira , Varela Concepción 
Published: November 2020

Purpose
This study aims to increase the understanding of the drivers of mobile shopping, by analyzing when and how two personality traits – value consciousness and shopping enjoyment – impact mobile shopping intention through usefulness and ease-of-use perceptions.

Design/methodology/approach
To test the conditioned indirect effects, path analysis is used.

Findings
The results indicate that both consumers’ value consciousness and shopping enjoyment have a positive indirect effect on mobile shopping intention. However, shopping enjoyment is related only through usefulness, whereas value consciousness is related via both usefulness and ease of use. The results also suggest the need to consider boundary conditions when examining the impact of personality traits.

Practical implications
Mobile retailers need to conduct market segmentation based on users’ personalities when trying to increase their customer base.

Originality/value
Despite the relevance of personality traits on individual behavior, studies on the effects that different aspects of personality have on the participation of individuals in mobile commerce are very scarce and show inconsistent results regarding their impact. Thus, this study tries to contribute to the mobile commerce research by analyzing the interplay between two customer characteristics and two mediating variables: ease-of-use and usefulness perceptions.
Evaluation of cyromazine transferred from feed to chicken products and subsequent assessment of dietary risks to Chinese consumers
Authors: Ji Xiaofeng , Yang Hua , Lyu Wentao , Wang Jianmei , Wang Xinquan , Wang Xiaoli , Qian Mingrong 
Published: November 2020

AbstractIn this work, levels of cyromazine and its metabolite melamine in chicken products and its transfer factors (TFs) and dietary risks assessment for Chinese consumers are presented. Cyromazine was added to chicken feed at doses of 5, 25, and 50 mg/kg for 42 days. Cyromazine residues were found in frequently consumed chicken products (meat, heart, liver, gizzard, and eggs), with liver and eggs displaying the highest concentrations (0.935 and 1.281 mg/kg, respectively). Low levels of melamine residues (<0.029 mg/kg) were detected in chicken products from chickens treated with 25 and 50 mg/kg cyromazine, but not in eggs from chickens treated with 5 mg/kg cyromazine. The TFs for the investigated chicken products varied from 0.0074 to 0.0229 across the dosage levels. The chronic exposure assessment showed that 0.001 to 0.190% of the acceptable daily intake (0.06 mg/kg body weight [b.w.]/day) of cyromazine was consumed through chicken products among the various age and gender groups of Chinese consumers. The acute exposure assessments of different age and gender groups were 0.0004% to 0.178% of the acute reference dose (0.1 mg/kg b.w.). Although the results suggest that the risk associated with cyromazine residues in chicken products was low in China, the possible risk associated with cyromazine residues in chicken products should not be ignored while cyromazine remains a legal feed additive.Practical ApplicationThe present analytical method could be used for cyromazine and melamine detection in different chicken products, and dietary risk assessments of cyromazine provided a support for the work of regulatory bodies to conduct surveillance programs regarding food safety evaluation of cyromazine.