bluuebunny/crossref_metadata_2025_split huggingface dataset:
Florbetapir Regional Distribution in Cerebral Amyloid Angiopathy and Alzheimer’s Disease: A PET Study
Authors: Planton Mélanie , Saint-Aubert Laure , Raposo Nicolas , Payoux Pierre , Salabert Anne-Sophie , Albucher Jean-François , Olivot Jean-Marc , Péran Patrice , Pariente Jérémie 
Published: January 2020

Background: Sporadic cerebral amyloid angiopathy shows progressive amyloid-β deposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. Objective: To investigate whether amyloid load and distribution, assessed by florbetapir positron emission tomography (PET), differs between patients with probable CAA-related intracerebral hemorrhage (CAA-ICH) and mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Methods: We assessed [18F]florbetapir uptake in 15 patients with probable CAA-ICH and 20 patients with MCI-AD patients. Global and regional florbetapir retention were assessed using standard uptake values ratio (SUVr) in region-based and voxel-wise approaches. Visual reading of florbetapir scans was performed for all participants. Group comparisons were performed using univariate and multivariate analysis. Results: Global florbetapir retention was lower in patients with CAA-ICH than MCI-AD (median SUVr, 1.33 [1.21–1.41] versus 1.44 [1.35–1.66]; p = 0.032). In the region-based analysis, regional florbetapir distribution was similar between the two groups. There was a trend for an increased occipital/global ratio in CAA-ICH patients compared to MCI-AD ( p = 0.060). In the voxel-wise approach, two clusters, one in parietal regions and the other in temporal regions, had higher uptake in MCI-AD relative to CAA patients. Conclusions: Patients with CAA-ICH had a lower global florbetapir PET burden than patients with MCI-AD. Relative florbetapir retention in the posterior regions tended to be higher in CAA patients in region-based analysis but was not statistically different between groups. Investigation on differences in amyloid deposits distribution between groups required a fine-grained voxel-wise analysis. In future studies, selective amyloid tracers are needed to differentiate vascular from parenchymal amyloid.
The Role of Free and Cued Selective Reminding Test in Predicting [18F]Florbetaben PET Results in Mild Cognitive Impairment and Mild Dementia
Authors: Spallazzi Marco , Michelini Giovanni , Barocco Federica , Dieci Francesca , Copelli Sandra , Messa Giovanni , Scarlattei Maura , Pavesi Giovanni , Ruffini Livia , Caffarra Paolo 
Published: January 2020

Background: Free and Cued Selective Reminding Test (FCSRT) is a reliable cognitive marker for Alzheimer’s disease (AD), and the identification of neuropsychological tests sensitive to the early signs of AD pathology is crucial both in research and clinical practice. Objective: The study aimed to ascertain the ability of FCSRT in predicting the amyloid load as determined from amyloid PET imaging (Amy-PET) in patients with cognitive disorders. Methods: For our purpose, 79 patients (71 MCI, 8 mild dementia) underwent a complete workup for dementia, including the FCSRT assessment and a [18F]florbetaben PET scan. FCSRT subitem scores were used as predictors in different binomial regression models. Results: Immediate free recall and delayed free recall were the best predictors overall in the whole sample; whereas in patients <76 years, all models further improved with immediate total recall (ITR) and Index of Sensitivity of Cueing (ISC) resulting the most accurate in anticipating Amy-PET results, with a likelihood of being Amy-PET positive greater than 85% for ITR and ISC scores of less than 25 and 0.5, respectively. Conclusion: FCSRT proved itself to be a valid tool in dementia diagnosis, also being able to correlate with amyloid pathology. The possibility to predict Amy-PET results through a simple and reliable neuropsychological test might be helpful for clinicians in the dementia field, adding value to a paper and pencil tool compared to most costly biomarkers.
A case of multitrauma with vena cava inferior isthmus injury
Authors: Yeniocak Selman , Yıldırım Sunay , Az Adem , Demirel Ahmet , Özden Muhammed Furkan , Uzun Özlem 
Published: January 2020

Abstract:

Introduction: Large vessel and cardiac injuries
may also be seen in high-energy blunt traumas such as traffic accidents. This
report describes a multitrauma patient with vena cava isthmus inferior injury
brought to the emergency department following high-energy blunt trauma.

Case: A 33-year-old woman was brought to the
emergency department following an in-vehicle traffic accident. On arrival, her
general condition was poor, and she was unconscious and hemodynamically
unstable. Physical examination revealed that the left hemithorax was enlarged
compared to the right, was distorted, and did not contribute equally to
respiration. Injury to the isthmus of the vena cava inferior and bleeding in
the pericardial cavity were observed in addition to abdominal injury symptoms
at thoracoabdominal computerized tomography. The patient was taken for
abdominal surgery. After surgical intervention, she was transferred to the intensive
care unit.

Conclusion: It should not be forgotten that
major vascular and cardiac injuries such as vena cava inferior isthmus injury
may also accompany other systemic injuries in patients subjected to high-energy
trauma.
Acute mechanical intestinal obstruction due to foreign body ingestion
Authors: Uysal Emin , Çelik Hakan , Hıncal Şakir Ömür , Türkdoğan Kenan Ahmet 
Published: January 2020

Introduction: Foreign body ingestion is usually occurs accidenatlly and is a common
condition in childhood, but it is rarely seen in adults and is frequently
encountered in people with mental retardation and psychiatric disease. The
outcome is usually defecation of the ingested materials but rarely requires
surgial intervention. Case Report: A 33-year-old male patient was admitted to
the emergency department with the complaint of constipation as a result of
swallowing about 1000 plastic buttons yesterday. His acute mechanical intestinal obstruction
was alleviated with conservative treatment and the patient discharged with
recommendations.Conclusion: The number, shape, size and time of ingestion determine the mode of
treatment. There are three main principles in treatment. Endoscopic retraction,
conservative follow-up and surgical intervention. In addition to, tomography
should be considered as an option for foreign bodies that can not be visualized
with direct radiography.
EFEKTIVITAS KEPEMIMPINAN KEPALA SEKOLAH: STUDI KASUS PADA SEKOLAH INTERNASIONAL X DI BALI
Authors: Sidupa Jeanny Novita 
Published: January 2020

Improving the educational quality can be done not only through improvements on instructional process such as curriculum, learning methods, the quality of teachers or educational facilities but also through principal leadership as the principal is directly related to the implementation of the school program. Data collection techniques used was interview, and documentation. The survey method is carried out only as an affirmation and supporting data. The research was conducted using qualitative descriptive approach. Moreover, to assure the validity of research, the data was tested through triangulation method. Based on the research findings, it was concluded that the hindrances on the effectiveness of principal leaders was caused by the absence of superintendents’ support in providing organizational structure, system and program which focused on school’s vision and mission. That being said, it was suggested that superintendent as a policy maker to put an effort to develop coordination and collaboration with all the stake holders as it will establish the school’s direction and foster a strong commitment in meeting those goals.

Kualitas mutu sumber daya manusia salah satunya ditentukan oleh kualitas mutu pendidikan.Untuk meningkatkan mutu pendidikan tidak hanya dapat dilakukan melalui perbaikan proses pembelajaran seperti kurikulum, metode pembelajaran, perbaikan kualitas guru atau sarana pendidikan tetapi juga melalui kepemimpinan kepala sekolah. Kepemimpinan kepala sekolah merupakan faktor penting dalam menentukan keberhasilan sekolah karena kepala sekolah berhubungan langsung dengan pelaksanaan program sekolah. Penelitian ini membahas mengenai pelaksanaan kepemimpinan kepala sekolah X di pulau Bali. Penelitian ini dilakukan menggunakan pendekatan kualitatif deskriptif, menggunakan pengamatan wawancara, dan dokumentasi. Metode survey dilakukan hanya sebagai penegasan dan data pendukung. Teknik analisis data menggunakan model analisis interaktif yang terdiri dari pengumpulan data, reduksi data, penyajian dan kesimpulan. Pengujian keabsahan data menggunakan triangulasi sumber. Berdasarkan hasil penelitian, disimpulkan bahwa kendala-kendala yang dihadapi kepala sekolah dalam menjalankan kepemimpinannya adalah kurangnya dukungan dari pihak yayasan sekolah dalam menciptakan standar, sistem dan program yang berorientasi pada visi, misi dan tujuan sekolah. Untuk itu yayasan sebagai pembuat kebijakan hendaknya melakukan koordinasi dan kolaborasi yang baik dengan seluruh warga sekolah sehingga dapat menentukkan arah kebijakan dan menumbuhkan komitmen yang kuat dalam pemenuhan tujuan sekolah.
META ANALISIS TUTORIAL ONLINE UNIVERSITAS TERBUKA
Authors: Wahyuningsih Sri Suharmini , Darmayanti Tri , Bintarti Arifah 
Published: January 2020

Online tutorial service was a learning support services provided by the Universitas Terbuka (UT) for its students. In the distance education system, the learning process could be done through the internet. Research on online tutorial learning and services has been done by UT lecturers. This article aimed to map research related to UT's online tutorials, both in the form of research reports and those that have been published in journals. The purpose of mapping was to find out what research topics regarding online tutorials that have been conducted. The research method used was the meta-analysis method, combining various analyzes which then produced a global analysis of online tutorials. The results of this study were online tutorial research could be categorized into five topics, namely a) the relationship between online tutorial values ​​and final exam scores; b) organizing online tutorials; c) the quality of online tutorials; d) online tutorial accessibility; and e) online tutorials as a research tool. Students rated the implementation of online tutorials as good and they were satisfied. The value of online tutorials could contribute to the value of final exam scores. However, the accessibility of online tutorials was still low because it depended on the network and students’ discipline and activeness.
Layanan tutorial online merupakan layanan bantuan belajar yang diberikan Universitas Terbuka (UT) untuk para mahasiswanya. Dalam sistem pendidikan jarak jauh proses pembelajaran dapat dilakukan melalui jaringan internet. Penelitian tentang layanan dan pembelajaran tutorial online sudah banyak dilakukan oleh dosen UT. Artikel ini bertujuan untuk memetakan penelitian yang berhubungan dengan tutorial online UT, baik dalam bentuk laporan penelitian maupun yang sudah dipublikasikan di jurnal. Tujuan pemetaan adalah untuk mengetahui apa saja topik penelitian mengenai tutorial online yang sudah dilakukan. Metode penelitian yang digunakan adalah metode meta analisis, menggabungkan berbagai analisis yang kemudian menghasilkan analisis global mengenai tutorial online. Hasil dari penelitian ini adalah penelitian tutorial online dapat dikategorikan menjadi lima topik, yaitu: a) Hubungan nilai tutorial online dengan nilai UAS; b) Penyelenggaraan tutorial online; c) Kualitas tutorial online; d) Aksesibilitas tutorial online; dan e) Tutorial online sebagai sarana atau alat penelitian. Mahasiswa menilai penyelenggaraan tutorial online sudah baik dan mahasiswa merasa puas. Nilai tutorial online dapat berkontribusi terhadap nilai UAS. Namun aksesibilitas tutorial online masih rendah karena bergantung kepada jaringan serta kedisiplinan dan keaktifan mahasiswa.
Impact of Direct Acting Antivirals on Survival in Patients with Chronic Hepatitis C and Hepatocellular Carcinoma
Authors: Zargar Mahrukh Hameed 
Published: January 2020

Hepatocellular carcinoma (HCC) represents a global public health burden, affecting an estimated 14 million persons worldwide, and is the third leading cause of cancer mortality. Within the United States, HCC is ranked 7th for cancer related mortality and has seen a doubling in incidence from 1975 to 2007. The primary predisposing factors for HCC carcinogenesis is liver cirrhosis. Cirrhosis risk factors include chronic alcohol use, viral hepatitis, including hepatitis c (HCV), and non-alcoholic fatty liver disease. Chronic HCV infection is the second most common risk factor for HCC and is responsible for 10–25% of all HCC cases. Over 20–30 years, 20–30% of patients with chronic HCV infections will develop cirrhosis and end stage liver disease and 1–4% of these patients will progress to HCC each year. Of all HCV related HCC cases, 80–90% occur in the setting of cirrhosis. With more than 3.5 million HCC patients in the United States and an estimated 130–170 million patients worldwide currently infected with HCV, the importance of HCV management in HCC therapeutic care and prevention is clear. The major current therapeutic goal for HCV and prevention of liver disease progression is sustained viral response (SVR), which is defined by negative HCV RNA at 12 weeks post-treatment (SVR12) and appears to be durable with a late virologic relapse rate of less than 1%. Therapeutic management of HCV has recently shifted from interferon-based therapies to all-oral interferon-free direct-acting antiviral (DAA) combination regimens. DAAs are a new class of drugs that target nonstructural proteins responsible for replication and infection of the hepatitis c virus. Genotype specific DAA therapies have been shown to reach SVR12 exceeding 90% of patients with fewer adverse effects compared with historic interferon-based regiments. SVR12 from DAA regimens have been associated with a decrease in liver outcomes including cirrhosis, hepatic decompensation, HCC and mortality. However, the impact of DAA regimens on clinical outcomes in patients with HCC remain limited. This study evaluates the impact of DAA on overall survival in HCV patients with HCC with the a priori hypothesis that SVR12 would be associated with improved outcome.
BATIK TULIS SEBAGAI WARISAN BUDAYA DUNIA DALAM MENANAMKAN RASA CINTA TANAH AIR GENERASI MUDA INDONESIA
Authors: Yudhi Lim 
Published: January 2020

ABSTRACT
Batik tulis, which is one of Indonesia's cultural heritages, is one of the media in instilling the love of the homeland, so that the younger generation feels more ownership and love of indigenous Indonesian culture. This research focuses on how batik tulis as a world cultural heritage in an effort to instill the love of the homeland of Indonesia's young generation. This study aims to make people aware of their concept of being Indonesian citizens, so that people can realize their love for their homeland with the use of batik in their daily lives. Research that uses the sociocultural tradition with symbolic interaction theory focuses attention on the level of mind, self, and society. This study uses the interpretive paradigm, because researchers view batik tulis to have its own uniqueness and contain original truths, so the truth or knowledge generated from research is contextual.

Keywords: love for the motherland, batik, symbolic interactions

ABSTRAK

Batik tulis yang merupakan salah satu warisan budaya Indonesia ialah salah satu media dalam menanamkan rasa cinta tanah air, agar generasi muda lebih merasa memiliki dan mencintai kebudayaan asli Indonesia. Penelitian ini berfokus pada bagaimana batik tulis sebagai warisan budaya dunia dalam upaya menanamkan rasa cinta tanah air generasi muda Indonesia. Penelitian ini bertujuan agar masyarakat memiliki kesadaran tentang konsep dirinya sebagai warga Indonesia, sehingga masyarakat bisa mewujudkan sikap cinta tanah airnya dengan penggunaan batik tulis dalam kehidupan sehari – hari. Penelitian yang menggunakan tradisi sosiokultural dengan teori interaksi simbolik ini memusatkan perhatian pada tataran pikiran, diri, dan masyarakat. Penelitian ini menggunakan paradigma interpretif, sebab peneliti memandang batik tulis memiliki keunikan tersendiri dan mengandung kebenaran yang orisinil, sehingga kebenaran atau pengetahuan yang dihasilkan dari penelitian bersifat kontekstual.

Kata kunci: cinta tanah air, batik tulis, interaksi simbolik
Influence of patient multimorbidity on GP burnout: a survey and register-based study in Danish general practice
Authors: Pedersen Anette Fischer , Nørøxe Karen Busk , Vedsted Peter 
Published: January 2020

BackgroundPatient multimorbidity and GP burnout are increasing problems in primary care and are potentially related.AimTo examine whether patient multimorbidity was associated with GP burnout in a Danish primary care setting.Design and settingQuestionnaire data from 1676 Danish GPs and register data on their patients.MethodGPs completed the Maslach Burnout Inventory. Patients listed in a national registry with ≥2 chronic physical diseases from a list of 10 were classified with multimorbidity. For each practice, crude and sex- and age-standardised rates of multimorbidity were calculated, the latter computed as a weighted average with the weights taken from a reference population (5 646 976 Danish citizens). Data were analysed with logistic regression and adjusted analyses included GPs’ age and sex, number of GPs in practice, and socioeconomic deprivation among patients as covariates.ResultsA high crude rate of patient multimorbidity increased GPs’ likelihood of burnout (odds ratio [OR] 1.79, 95% confidence interval [CI] = 1.13 to 2.82), and when adjusting for covariates the association remained significant when comparing GPs in the third highest quartile of the multimorbidity rate against GPs in the lowest quartile (OR 1.64, 95% CI = 1.02 to 2.64). The sex- and age-standardised patient multimorbidity rate was not associated with GPs’ likelihood of burnout.ConclusionA high crude rate of patient physical multimorbidity increased the likelihood of burnout among GPs. The sex- and age-standardised rate of multimorbidity was not related to GPs’ likelihood of burnout. Thus, the absolute amount of multimorbidity, and not the relative, affects the GP’s burnout risk. GPs with high numbers of patients with complex needs should be supported to prevent suboptimal care and GP burnout.
Experiences of support from primary care and perceived needs of parents bereaved by suicide: a qualitative study
Authors: Wainwright Verity , Cordingley Lis , Chew-Graham Carolyn A , Kapur Nav , Shaw Jenny , Smith Shirley , McGale Barry , McDonnell Sharon 
Published: January 2020

BackgroundPeople bereaved by suicide are a vulnerable group, also at risk of dying by suicide. The importance of postvention support (intervention after suicide) has recently been highlighted; however, little is known about the support needs of parents bereaved by suicide in the UK, and the role played by general practice.AimTo explore the perspectives, experiences, and support needs of parents bereaved by suicide.Design and settingThis was a qualitative study, with semi-structured interviews conducted between 2012 and 2014 in the north of England and the Midlands, with parents bereaved by their son or daughter’s suicide.MethodInterviews explored parents’ experiences of suicide bereavement following the death of their son or daughter, with a focus on their experiences of support from primary care. Interviews were analysed thematically using constant comparison.ResultsTwenty-three interviews were conducted. Three themes were identified from the data: the importance of not feeling alone; perceived barriers to accessing support; and the need for signposting for additional support. Some parents reported having experienced good support from their general practice; others described a number of barriers to accessing help, including triage processes. Primary care was considered to be an important avenue of support but GPs were often perceived as uncertain how to respond. The need for information, signposting to avenues of support, and the helpfulness of group support were also highlighted.ConclusionParents believed it was important that people working in general practice have an awareness of suicide bereavement and understanding of their needs, including knowledge of where to direct people for further support.
Pengaruh Tingkat Pemahaman Mahasiswa Terhadap Keputusan Memilih Jurusan Ekonomi dan Perbankan Syariah (Studi Perguruan Tinggi di Wilayah Kalimantan Timur)
Authors: Pratiwi Angrum 
Published: January 2020

Pemahaman diartikan juga perihal menguasai, mengerti, atau memahami. Pemahaman merupakan proses berpikir dan belajar, dikatakan demikian karena untuk menuju kearah pemahaman perlu diikuti dengan belajar dan berpikir secara mendalam. Pembelajaran pada fakultas ekonomi dan bisnis Islam harus menghasilkan alumni yang profesional sejalan dengan perkembangan kebutuhan sumber daya insani yang memahami ekonomi Islam dengan baik. Pembelajaran ini dilakukan dengan tujuan menghasilkan lulusan yang berakhlak, profesional, serta memahami dengan baik ilmu ekonomi dan keuangan sesuai dengan ajaran Islam. Tujuan penelitian ini adalah untuk mengetahui sejauh mana tingkat pemahaman mahasiswa terkait Ekonomi Syariah atau Perbankan Syariah di perguruan tinggi wilayah Kalimantan Timur. Mengetahui apakah terdapat pengaruh tingkat pemahaman mahasiwa terhadap keputusan memilih jurusan Ekonomi Syariah atau Perbankan Syariah di perguruan tinggi wilayah Kalimantan Timur.
Penelitian ini merupakan penelitian lapangan (field research), dengan pendekatan kuantitatif asosiatif, yaitu statistik yang berfungsi untuk menguji apakah terdapat pengaruh tingkat pemahaman terhadap keputusan memilih jurusan Ekonomi Syariah atau Perbankan Syariah. Sumber data yaitu data primer yang diperoleh langsung dari lapangan, berupa data akademik, data jumlah mahasiswa, hasil kuesioner dan data lain yang sesuai dengan tujuan penelitian. Sampel berjumlah 448 responden, yang tersebar di empat perguruan tinggi yang telah menyelenggarakan program Ekonomi Syariah atau Perbankan Syariah. Variabel independen adalah tingkat pemahaman mahasiswa akan Ekonomi Syariah atau Perbankan Syariah, sedangkan variabel dependen adalah keputusan memilih jurusan ekonomi syariah atau perbankan syariah.
Hasil penelitian menunjukkan bahwa tingkat pemahaman berpengaruh positif dan siginifikan (Sig. 0.000) terhadap keputusan mahasiswa memilih jurusan/program studi ekonomi syariah atau perbankan syariah. Hasil uji determinasi menunjukkan hasil R Square yaitu sebesar 0.259, artinya sebesar 25.9% tingkat pemahaman mahasiswa mampu menerangkan atau mempengaruhi keputusan memilih jurusan ekonomi atau perbankan Islam pada perguruan tinggi di Kalimantan Timur, sisanya 74.1% dipengaruhi oleh faktor lainnya yang tidak diteliti pada penelitian ini.
A similaridade genética de Escherichia coli patogênica para as aves (APEC) com estirpes humanas e a resistência antimicrobiana justificam a preocupação sanitária em relação aos produtos de origem aviária?
Authors: Knöbl Terezinha , Cunha Marcos Paulo Vieira , Menão Márcia Cristina , Ferreira Antonio José Piantino 
Published: January 2020

Escherichia coli é um patógeno de importância para a medicina humana e veterinária em função dos inúmeros agravos de saúde causados por patotipos intestinais (EPEC, ETEC, EIEC, EHEC e EaggEC) e extra-intestinais (ExPEC). A similaridade genética entre cepas de E.coli patogênica para as aves (APEC) e cepas associadas a infecções do trato urinário (UPEC), meningite e sepse humana (NMEC) se tornou alvo de investigação nos últimos anos, revelando uma preocupação sanitária na cadeia de produção de aves. Além da hipótese sobre o caráter zoonótico das amostras de origem aviária, é mundialmente crescente a preocupação referente ao aumento da resistência antimicrobiana entre as enterobactérias. Este artigo faz uma revisão do assunto, com vistas aos riscos sanitários associados à APEC.