bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal interventional oncology: current and future practices
Authors: Cazzato Roberto Luigi , Garnon Julien , Koch Guillaume , Dalili Danoob , Rao Pramod Prabhakar , Weiss Julia , Bauones Salem , Auloge Pierre , de Marini Pierre , Gangi Afshin 
Published: August 2020

Management of musculoskeletal (MSK) tumours has traditionally been delivered by surgeons and medical oncologists. However, in recent years, image-guided interventional oncology (IO) has significantly impacted the clinical management of MSK tumours. With the rapid evolution of relevant technologies and the expanding range of clinical indications, it is likely that the impact of IO will significantly grow and further evolve in the near future.In this narrative review, we describe well-established and new interventional technologies that are currently integrating into the IO armamentarium available to radiologists to treat MSK tumours and illustrate new emerging IO indications for treatment.
Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts
Authors: Uehara Kyonori , Hisatomi Miki , Munhoz Luciana , Kawazu Toshiyuki , Yanagi Yoshinobu , Okada Shunsuke , Takeshita Yohei , Saito Emiko Arita , Asaumi Junichi 
Published: August 2020

Objectives: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). Methods: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey–Kramer honestly significant difference test. Results: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). Conclusions: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.
Rising HIV seroconversion rates & associated risks among employees of organization ‘X’: A case control study, Pakistan, 2017
Authors: Mansoor Eisha , Azam Naila , Niazi Saifullah Khan , Sheikh Naveen , Baig Mirza Amir , Azim Mansoor Tariq , Klair Nimra 
Published: August 2020

Background and Objectives: In 2004 Pakistan escalated from ‘low-prevalence’ to ‘concentrated’ phase of HIV epidemic. Despite global decline in HIV incidence since 1997, rate of HIV infections in Pakistan is persistently rising since 1990. Available literature focusses on key populations or localized outbreaks limited by short study duration and regional applicability of results. We studied HIV seroconversion trends over a period of 8 years in a geographically diverse population and evaluated associated risk factors.
Methods: A desk review of HIV surveillance data from 2010 to 2017 was carried out at Armed Forces Institute of Pathology. A case was defined as any adult employed in organization ‘X’, initially screened for HIV but later seroconverted on ELISA and western blot. Case-control study was conducted on cases diagnosed in 2017. Age and sex matched controls were identified from same population sub-group. Structured telephonic interviews were conducted and statistical analysis done at 5% margin of error.
Results: The annual HIV diagnosis rate remained relatively stable till 2015 (< 40 /100,000/yr) after which it rose sharply to 60/100,000/yr in 2016. Upward trend continued in 2017 to reach 125/100,000/yr (>200% increase from baseline). Acquisition of HIV was significantly associated with commercial sex activities (OR=9; 95%CI: 1.25-395).
Conclusion: HIV seroconversion rates among employees of organization X have increased significantly in the past two years. Unlike HIV outbreaks previously reported from Pakistan, sexual route seems to be the predominant mode of transmission. Focus is mandated on prevention of sexual transmission of HIV at national level as well for all vulnerable populations.
doi: https://doi.org/10.12669/pjms.36.6.1735
How to cite this:Mansoor E, Azam N, Niazi SK, Sheikh N, Baig MA, Azim MT, et al. Rising HIV seroconversion rates & associated risks among employees of organization ‘X’: A case control study, Pakistan, 2017. Pak J Med Sci. 2020;36(6):1349-1354. doi: https://doi.org/10.12669/pjms.36.6.1735
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Metabolic syndrome in systemic lupus erythematosus was closely related to body mass index, blood pressure, blood sugar, blood lipids, and arthritis
Authors: Jin Lai-Run , Tao Meng-Jun , Zhou Jun , Xu Liang , Li Qiang , Li Zhi , Peng Hui , Yuan Hui 
Published: August 2020

Background and Objective: Prevention and control of metabolic syndrome is the key to improving the development of systemic lupus erythematosus. The aim of this study was to analyze the relevant factors regarding metabolic syndrome (MS) in systemic lupus erythematosus (SLE).
Methods: A total number of 1238 SLE patients in Yijishan Hospital of Wannan Medical College, Anhui province, from February 2012 to July 2017, were analyzed retrospectively. SLE patients with MS were grouped to group SLE-MS, the others without MS was grouped to group SLE-nMS. The two groups were compared with respect to general characteristics, clinical signs, and laboratory parameters. Random forest approach and multivariate logistic regression were conducted to analyze the related factors regarding MS in SLE.
Results: The constituent ratio of metabolic syndrome was 27.14% (336/1238). More SLE patients with MS presented with more farmers, more married people, lower education level, and more lupus nephritis, proteinuria, oral ulcers, tubular urine, hematuria than SLE patients without MS (P<0.05). Moreover, eighteen important variables, whose average importance scores were highest and whose error rates were lowest, were selected by random forest method. Data from multivariate logistic regression showed that MS in SLE was related with BMI, diastolic blood pressure, systolic blood pressure, fasting blood glucose, arthritis, urea, triglycerides, high-density lipoprotein, and white blood cells.
Conclusion: MS in SLE was closely related to BMI, blood pressure, blood sugar, blood lipids, arthritis, white blood cells, and urea. Targeted prevention and conclusion measures for the risk factors should be taken as early as possible.
doi: https://doi.org/10.12669/pjms.36.6.2093
How to cite this:Jin LR, Tao MJ, Zhou J, Xu L, Li Q, Li Z, et al. Metabolic syndrome in systemic lupus erythematosus was closely related to body mass index, blood pressure, blood sugar, blood lipids, and arthritis. Pak J Med Sci. 2020;36(6):1220-1227. doi: https://doi.org/10.12669/pjms.36.6.2093
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cytotoxic effects of manganese oxide nanoparticles in combination with microbial components on intestinal epithelial cells
Authors: Fredericks Jorrell , Senapati Sujata , Wannemuehler Michael J. 
Published: August 2020

Background: Manganese oxide has been shown to cause toxicity and is associated with occupational-related disease (e.g., welders). With the goal to improve several biomedical areas, manganese oxide nanoparticles (MnO NP) are being considered for use in drug delivery and magnetic resonance imaging (MRI) to obtain high resolution anatomical images of tumors and gastrointestinal (GI) inflammation. Regardless of whether it is intentional or unintentional ingestion, the GI tract has been shown to be the primary route of entry for metal nanoparticles including MnO NP. However, studies assessing toxicity of MnO NP for intestinal epithelial cells (IECs) are virtually nonexistent. Methods: Given the proximity to the GI lumen, assessing the effects of nanoparticles on IECs in the presence of bacterial components presents a more holistic model of exposure. Therefore, we examined the effects of MnO NP alone and MnO NP in combination with Escherichia coli LF82 bacterial lysate on selected functions of MODE-K cells, a murine intestinal epithelial cell line. Data were analyzed using one-way ANOVA. Differences with p < 0.05 were considered significant. Results: Results showed MnO NP plus E. coli LF82 lysate added to MODE-K cells severely inhibited monolayer scratch wound healing, enhanced the secretion of interleukin 6 (IL-6), and induced mitochondrial dysfunction. Conclusions: Overall, our findings show that toxicity of MnO NP deleteriously affected MODE-K cells and demonstrated the necessity to integrate other environmental factors, such as microbial components and/or inflammatory cytokines, into studies assessing effects of nanoparticles on mucosal epithelia.
VET Realignment and the Development of Technical Elites: Learning at Work in England
Authors: Esmond Bill , Atkins Liz 
Published: August 2020

Context: An enhanced role for work-based learning is advocated increasingly widely across industrialised countries and by international Vocational Education and Training (VET) policies. However, this is framed differently in each country by long-term policy orientations that reflect VET’s relationship with wider economic and social formations. These national differences reflect path dependency but also distinctive responses to contemporary challenges such as globalisation. In England, recent reforms strengthening workplace learning are constrained by existing patterns of skill formation and may be shaped by further market liberalisation and divergence from social and economic policies in Europe. Approach: The study examined the relationship between greater emphasis on workplace learning in England and societal change, addressing the research question: how are early experiences of work in England, as part of young people’s full-time education programmes, positioning them for future employment? Case studies were organised around apparently distinctive placement types that had emerged from earlier studies. Using the constant comparative method, the team identified a series of categories to distinguish the way each type of work-based learning positioned students in a particular type of labour market transition.Findings: Evidence emerged of divergence in England’s "further education" system, across mainly male "technical" routes, young people on vocational courses preparing them for routine, low-skilled, precarious employment, and an area of greater uncertainty preparing young people for digital routes linked to the "new economy". Key dimensions of difference included study locations, discourses of occupational status, types of valued learning content, approaches to socialisation, sources of expertise and processes of credentialisation. In each case, learning at work served to position students for a particular type of labour market transition, which we characterise as technical elite formation, welfare VET and new economy precarity.Conclusion: Approaches to workplace learning in England already reflect social distinctions but entail the possibility of reinforcing these, supporting a more hierarchical pattern of labour market transition. Whilst the upper strata of VET shift their purpose to support the formation of new "technical elites", others face the possibility of further marginalisation. Such new inequalities could become central to a further fragmented society in a post-Brexit, post-COVID-19 Britain. Other European states facing challenges of globalisation and the transition to services are also likely to experience pressures for VET stratification, although they may seek less divisive solutions.
A Conserved Role for Vezatin Proteins in Cargo-Specific Regulation of Retrograde Axonal Transport
Authors: Spinner Michael A , Pinter Katherine , Drerup Catherine M , Herman Tory G 
Published: August 2020

Abstract
Vertebrate Vezatin is associated with the regulation of cell-cell junctions. A distantly-related¬Aspergillus¬protein, VezA, promotes dynein-dependent transport of endosomes within hyphae, but there has been no evidence.....
A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae
Authors: Paulissen Scott M , Hunt Cindy A , Seitz Brian C , Slubowski Christian J , Yu Yao , Mucelli Xheni , Truong Dang , Wallis Zoey , Nguyen Hung T , Newman-Toledo Shayla , Neiman Aaron M , Huang Linda S 
Published: August 2020

Abstract
Meiosis in the budding yeast Saccharomyces cerevisiae is used to create haploid yeast spores from a diploid mother cell. During meiosis II, cytokinesis occurs by closure of the prospore membrane, a membrane that initiates at the spindle pole body and grows to surround each of the haploid meiotic products. Timely prospore membrane closure requires SPS1, which encodes an STE20 family GCKIII kinase. To identify genes that may activate SPS1, we utilized a histone phosphorylation defect of sps1 mutants to screen for genes with a similar phenotype and found that cdc15 shared this phenotype. CDC15 encodes a Hippo-like kinase that is part of the mitotic exit network. We find that Sps1 complexes with Cdc15, that Sps1 phosphorylation requires Cdc15, and that CDC15 is also required for timely prospore membrane closure. We also find that SPS1, like CDC15, is required for meiosis II spindle disassembly and sustained anaphase II release of Cdc14 in meiosis. However, the NDR-kinase complex encoded by DBF2/DBF20MOB1 which functions downstream of CDC15 in mitotic cells, does not appear to play a role in spindle disassembly, timely prospore membrane closure, or sustained anaphase II Cdc14 release. Taken together, our results suggest that the mitotic exit network is rewired for exit from meiosis II, such that SPS1 replaces the NDR-kinase complex downstream of CDC15.
La óptima enseñanza en la formación de profesionales cirujano dentistas en el Perú en tiempos de pandemia
Authors: Puerta Jarama Pedro Antonio 
Published: August 2020

Sr. Editor.
A raíz de la pandemia ocasionada por el COVID-19, las facultades de odontología en el Perú vienen adecuando y perfilando sus metodologías de enseñanza-aprendizaje en la formación profesional de los futuros cirujano dentistas.
IE – CEPA : ANALISIS MANFAAT DAN DAMPAK BAGI PERIKANAN INDONESIA
Authors: Zulham Armen , Hafsaridewi Rani 
Published: August 2020

Indonesia – EFTA Comprehensive Economic Partnership Agreement (IE-CEPA) adalah bentuk kerjasama perdagangan Indonesia dengan empat negara EFTA (Islandia, Liechtenstein, Norwegia, dan Swiss) untuk mendorong pertumbuhan ekonomi. Secara politis, kerjasama ini mempunyai arti strategis untuk memperluas pasar, karena nilai transaksi barang dan jasa negara EFTA berperan penting dalam perdagangan dunia. Kajian ini disusun dengan memanfaatkan data sekunder dan publikasi yang ada guna menelaah manfaat kerjasama perdagangan tersebut dalam pengembangan industri perikanan Indonesia. Hasil telaahan menunjukkan manfaat kerjasama tersebut masih memerlukan negosiasi yang kuat, karena dua negara EFTA (Islandia dan Norwegia) merupakan negara perikanan dan memiliki teknologi yang relatif maju. Dua negara EFTA lainnya merupakan jalan untuk memperluas pasar bagi produkperikanan Indonesia, serta mendorong dan meningkatkan investasi Perikanan. Indonesia perlu merintis penerapan rule of origin untuk kelangsungan perdagangan perikanan Indonesia dalam perdagangan global. Indonesia harus meningkatkan kapasitas sumberdaya manusia untuk memperkuat kerjasama tersebut serta mencegah perdagangan ikan yang tidak fair karena hasil transhipment, hasil tangkapan illegal dan re-ekspor ke Indonesia. Title: IE-CEPA: Benefit and Impact for Indonesia’s Fisheries Indonesia – EFTA Comprehensive Economic Partnership Agreement (IE-CEPA) is a trade cooperation between Indonesia and EFTA countries (Iceland, Liechtenstein, Norway and Switzerland) to support the economic growth. From Indonesia political point of view, this trade cooperation has a strategic position for market access due to the EFTA countries play important roles in global commodities and services trading. This analysis used the secondary data and published literatures to analysis impacts and benefits of this trade cooperation for fisheries development in Indonesia. Result of the analysis suggested that Indonesia still need to strengthen its negotiation due to the advanced stage of fishing technology from two EFTA countries (Iceland and Norway). Other two EFTA members are potential market access for Indonesian fish products. Indonesia has to implement rule of origin for sustainable fish trade to increase fish investment and increase completion in global market. Indonesia must improve its human capacity building to strengthen its position in this trade cooperation and prevent unfair fish trade due to trans-shipment, illegal fishing and re-export fish to Indonesia.
ANALISIS KEBIJAKAN INTRODUKSI SPESIES IKAN ASING DI PERAIRAN UMUM DARATAN PROVINSI ACEH
Authors: Muchlisin Z. A. 
Published: August 2020

Provinsi Aceh memiliki potensi perikanan perairan umum daratan yang besar dengan berbagai spesies lokal. Potensi ini belum sepenuhnya dimanfaatkan baik untuk perikanan tangkap maupun budidaya. Di sisi lain, tekanan terhadap perairan umum daratan semakin meningkat terutama disebabkan oleh kerusakan lingkungan, pencemaran, pemanasan global dan introduksi spesies ikan asing yang mengancamkomunitas ikan lokal. Introduksi spesies ikan asing menjadi isu penting, baik di tataran global maupun lokal. Kajian ini bertujuan untuk menganalisis dan mengadvokasi awal kebijakan introduksi spesies ikan asing di Provinsi Aceh. Untuk memberikan gambaran yang lebih jelas, kajian ini menggunakan studi kasus introduksi spesies ikan asing di Danau Laut Tawar. Kajian ini menggunakan metode analisis deskriptif-eksploratif dan studi literatur sebagai basis kebijakan introduksi spesies ikan asing yang perlu mendapatkan perhatian. Hasil kajian menunjukkan sebanyak sembilan spesies ikan asing telah ada diperairan Aceh. Dari jumlah tersebut, tujuh spesies diantaranya telah hadir di Danau Laut Tawar. Saat ini Pemerintah Provinsi Aceh belum memiliki kebijakan untuk mengatur introduksi spesies ikan asing ke perairan Aceh. Hal ini dapatmenyebabkan ancaman terhadap spesies ikan lokal. Karena itu kebijakan berupa peraturan daerah yang mengatur hal tersebut sangat diperlukan. Title: Policy Analysis of Introducing Alien Species of Fish in Inland Waters of Aceh Province Aceh Province has abundance of inland fishery resources with various indigenous species. These resources are still underutilized both for aquaculture or capture fisheries. On the other hand, environmental pressures and threats to these resources are emerging due to ecological devastation, pollution, introduced alien species and global warming. Introduction of alien species of fish become a popular issue in local orglobal contexts. The objective of this research was to analyze and initiate advocacy on introduction of alien fish species regulation in Aceh Province. This research used a case study in Lake Laut Tawar to give a comprehensive understanding on the topic. Descriptive-explorative analysis and literature review were used in the study, and the results of the study can be used to develop a better conservation strategy andpolicy to control introduced alien species in Aceh waters. This research results show there are at least nine introduced alien species of fish in Aceh waters. Seven of them were found in Lake Laut Tawar. Aceh Provincial Government has no regulation on introduction of alien species into Aceh waters. This condition could threaten the indigenous species of Aceh fishes. Therefore, the regulation of the management of introduced fish species is really needed.
Supported Decision Making Model as a Tool and Form for Socialization of People with Psychosocial Disabilities: Legal and Social Education Challenges in Lithuania
Authors: Juodkaitė Dovilė 
Published: August 2020

The aim of this article is to introduce the new concept of supported decision making model. Supported decision making model (SDM) as a tool for proper implementation of the rights of persons with disabilities is foreseen in the newest international human rights treaty – Convention on the rights of people with disabilities (CRPD). As a new concept SDM raises number of challenges both of legal, social and educational aspects how to introduce and implement this model in practice in order to safeguard rights and ensure social integration and socialization of the most vulnerable persons with psychosocial disabilities in the society.
Specific objectives of the study carried out were: to review new legal requirements of art. 12 of CRPD for ensuring equality before the law for all persons with disabilities, to critically analyze Lithuanian legal guardianship system for its compliance / noncompliance to those international requirements; to review and analyze supported decision making models existing in other countries; based on the comparative analysis of the supported decision making models, to make recommendations for Lithuanian legislation, legal and social practice on possible supported decision making model.
The practice in applying and ways to improve criteria for establishing the degree of occupational disability in the territory of the Russian Federation
Authors: Sevastianov M A , Penina G O , Dedeneva I V , Chistyakova N P , Bozhkov I A 
Published: August 2020

Aim. To assess the practice in applying Temporary criteria of determination of extent of loss of professional working capacity currently in force in various constituent entities of the Russian Federation and to substantiate the main directions for their improvement.
Methods. The analysis of expert decisions to establish the degree of occupational disability, adopted in the period from 2015 to 2017, was carried out in 77 subjects of the Russian Federation for two nosological forms: (1) consequences of lower limb injuries (T93) and (2) bilateral sensorineural hearing loss (H83.3). A comparative analysis of expert decisions made using current and proposed by the authors criteria in 2 constituent entities of the Russian Federation in 2018 was carried out. For data analysis, we used descriptive statistics methods.
Results. Taking into account a high variability in expert decisions making in the constituent entities of the Russian Federation for similar cases (coefficient of variation 21.6%), the authors conclude that it is necessary to change approaches to the methodology for assessing the type of professional activity (qualifications, quality and volume of work, ability to perform it). Using the authors propose criteria based on the concept of reasonable accommodation allowed us to significantly reduce the variability of the decisions made in the pilot regions, the coefficient of variation decreased from 21.25 to 7.43%.
Conclusion. High variability of decisions made during the examination of the degree of occupational disability is associated with the imperfection of the methods and criteria for assessing the victim's professional activities; the use of the criteria proposed by the authors allows for a higher reproducibility of the results of the examinations.