bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributed Fiber Optic Sensing System for Well‐Based Monitoring Water Injection Tests—A Geomechanical Responses Perspective
Authors: Sun Yankun , Xue Ziqiu , Hashimoto Tsutomu , Lei Xinglin , Zhang Yi 
Published: December 2019

AbstractIn this study, distributed fiber optic sensing (DFOS) based on hybrid Brillouin‐Rayleigh backscattering is examined for the first time in well‐based monitoring distributed profiles of geomechanical deformation induced by water injection. Field water injection tests are conducted under different injection scenarios between an injection well (230 m, IW #2) and 5.5 m away from a fibered monitoring well (300 m, MW #1) by deploying cables behind the casing at Mobara, Japan. Effects of injection rate, pressure, and lithological heterogeneity on the geomechanical deformation are quantitatively monitored via a DFOS approach and indicate that induced strains significantly depend on injection rate and pressure. The results also indicate that DFOS results are reasonably consistent with simultaneous geophysical well logging data and corresponding numerical simulation. The extent of impacted areas and magnitude of near‐wellbore strains are explored to evaluate formation heterogeneity and fluid migration behaviors. The field testing of hybrid DFOS technology is expected to definitely advance elaborate monitoring and wider applications, such as CO2 geosequestration sites.
Nonreciprocal metasurface with space–time phase modulation
Authors: Guo Xuexue , Ding Yimin , Duan Yao , Ni Xingjie 
Published: December 2019

AbstractCreating materials with time-variant properties is critical for breaking reciprocity that imposes fundamental limitations on wave propagation. However, it is challenging to realize efficient and ultrafast temporal modulation in a photonic system. Here, leveraging both spatial and temporal phase manipulation offered by an ultrathin nonlinear metasurface, we experimentally demonstrated nonreciprocal light reflection at wavelengths around 860 nm. The metasurface, with travelling-wave modulation upon nonlinear Kerr building blocks, creates spatial phase gradient and multi-terahertz temporal phase wobbling, which leads to unidirectional photonic transitions in both the momentum and energy spaces. We observed completely asymmetric reflections in forward and backward light propagations over a large bandwidth around 5.77 THz within a sub-wavelength interaction length of 150 nm. Our approach highlights a potential means for creating miniaturized and integratable nonreciprocal optical components.
Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways
Authors: Foo Jerome C. , Trautmann Nina , Sticht Carsten , Treutlein Jens , Frank Josef , Streit Fabian , Witt Stephanie H. , De La Torre Carolina , von Heydendorff Steffen Conrad , Sirignano Lea , Chen Junfang , Müller-Myhsok Bertram , Meyer-Lindenberg Andreas , Witt Christian C. , Gilles Maria , Deuschle Michael , Rietschel Marcella 
Published: December 2019

AbstractTherapeutic sleep deprivation (SD) rapidly induces robust, transient antidepressant effects in a large proportion of major mood disorder patients suffering from a depressive episode, but underlying biological factors remain poorly understood. Research suggests that these patients may have altered circadian molecular genetic ‘clocks’ and that SD functions through ‘resetting’ dysregulated genes; additional factors may be involved, warranting further investigation. Leveraging advances in microarray technology enabling the transcriptome-wide assessment of gene expression, this study aimed to examine gene expression changes accompanying SD and recovery sleep in patients suffering from an episode of depression. Patients (N = 78) and controls (N = 15) underwent SD, with blood taken at the same time of day before SD, after one night of SD and after recovery sleep. A transcriptome-wide gene-by-gene approach was used, with a targeted look also taken at circadian genes. Furthermore, gene set enrichment, and longitudinal gene set analyses including the time point after recovery sleep, were conducted. Circadian genes were significantly affected by SD, with patterns suggesting that molecular clocks of responders and non-responders, as well as patients and controls respond differently to chronobiologic stimuli. Notably, gene set analyses revealed a strong widespread effect of SD on pathways involved in immune function and inflammatory response, such as those involved in cytokine and especially in interleukin signalling. Longitudinal gene set analyses showed that in responders these pathways were upregulated after SD; in non-responders, little response was observed. Our findings emphasize the close relationship between circadian, immune and sleep systems and their link to etiology of depression at the transcriptomic level.
Electrodeposition of crystalline silicon films from silicon dioxide for low-cost photovoltaic applications
Authors: Zou Xingli , Ji Li , Ge Jianbang , Sadoway Donald R. , Yu Edward T. , Bard Allen J. 
Published: December 2019

AbstractCrystalline-silicon solar cells have dominated the photovoltaics market for the past several decades. One of the long standing challenges is the large contribution of silicon wafer cost to the overall module cost. Here, we demonstrate a simple process for making high-purity solar-grade silicon films directly from silicon dioxide via a one-step electrodeposition process in molten salt for possible photovoltaic applications. High-purity silicon films can be deposited with tunable film thickness and doping type by varying the electrodeposition conditions. These electrodeposited silicon films show about 40 to 50% of photocurrent density of a commercial silicon wafer by photoelectrochemical measurements and the highest power conversion efficiency is 3.1% as a solar cell. Compared to the conventional manufacturing process for solar grade silicon wafer production, this approach greatly reduces the capital cost and energy consumption, providing a promising strategy for low-cost silicon solar cells production.
Distributed sensing of microseisms and teleseisms with submarine dark fibers
Authors: Williams Ethan F. , Fernández-Ruiz María R. , Magalhaes Regina , Vanthillo Roel , Zhan Zhongwen , González-Herráez Miguel , Martins Hugo F. 
Published: December 2019

AbstractSparse seismic instrumentation in the oceans limits our understanding of deep Earth dynamics and submarine earthquakes. Distributed acoustic sensing (DAS), an emerging technology that converts optical fiber to seismic sensors, allows us to leverage pre-existing submarine telecommunication cables for seismic monitoring. Here we report observations of microseism, local surface gravity waves, and a teleseismic earthquake along a 4192-sensor ocean-bottom DAS array offshore Belgium. We observe in-situ how opposing groups of ocean surface gravity waves generate double-frequency seismic Scholte waves, as described by the Longuet-Higgins theory of microseism generation. We also extract P- and S-wave phases from the 2018-08-19 $${M}_{w}8.2$$Mw8.2 Fiji deep earthquake in the 0.01-1 Hz frequency band, though waveform fidelity is low at high frequencies. These results suggest significant potential of DAS in next-generation submarine seismic networks.
An extreme sea level indicator for the contiguous United States coastline
Authors: Rashid Md. Mamunur , Wahl Thomas , Chambers Don P. , Calafat Francisco M. , Sweet William V. 
Published: December 2019

AbstractWe develop an aggregated extreme sea level (ESL) indicator for the contiguous United States coastline, which is comprised of separate indicators for mean sea level (MSL) and storm surge climatology (SSC). We use water level data from tide gauges to estimate interannual to multi-decadal variability of MSL and SSC and identify coastline stretches where the observed changes are coherent. Both the MSL and SSC indicators show significant fluctuations. Indicators of the individual components are combined with multi-year tidal contributions into aggregated ESL indicators. The relative contribution of the different components varies considerably in time and space. Our results highlight the important role of interannual to multi-decadal variability in different sea level components in exacerbating, or reducing, the impacts of long-term MSL rise over time scales relevant for coastal planning and management. Regularly updating the proposed indicator will allow tracking changes in ESL posing a threat to many coastal communities, including the identification of periods where the likelihood of flooding is particularly large or small.
Expansion of the cassava brown streak pandemic in Uganda revealed by annual field survey data for 2004 to 2017
Authors: Alicai Titus , Szyniszewska Anna M. , Omongo Christopher A. , Abidrabo Phillip , Okao-Okuja Geoffrey , Baguma Yona , Ogwok Emmanuel , Kawuki Robert , Esuma Williams , Tairo Fred , Bua Anton , Legg James P. , Stutt Richard O. J. H. , Godding David , Sseruwagi Peter , Ndunguru Joseph , Gilligan Christopher A. 
Published: December 2019

AbstractCassava brown streak disease (CBSD) is currently the most devastating cassava disease in eastern, central and southern Africa affecting a staple crop for over 700 million people on the continent. A major outbreak of CBSD in 2004 near Kampala rapidly spread across Uganda. In the following years, similar CBSD outbreaks were noted in countries across eastern and central Africa, and now the disease poses a threat to West Africa including Nigeria - the biggest cassava producer in the world. A comprehensive dataset with 7,627 locations, annually and consistently sampled between 2004 and 2017 was collated from historic paper and electronic records stored in Uganda. The survey comprises multiple variables including data for incidence and symptom severity of CBSD and abundance of the whitefly vector (Bemisia tabaci). This dataset provides a unique basis to characterize the epidemiology and dynamics of CBSD spread in order to inform disease surveillance and management. We also describe methods used to integrate and verify extensive field records for surveys typical of emerging epidemics in subsistence crops.
Characterization of a human liver reference material fit for proteomics applications
Authors: Davis W. Clay , Kilpatrick Lisa E. , Ellisor Debra L. , Neely Benjamin A. 
Published: December 2019

AbstractThe National Institute of Standards and Technology (NIST) is creating new, economical, qualitative reference materials and data for proteomics comparisons, benchmarking and harmonization. Here we describe a large dataset from shotgun proteomic analysis of RM 8461 Human Liver for Proteomics, a reference material being developed. Consensus identifications using multiple search engines and sample preparations demonstrate a homogeneous and fit-for-purpose material that can be incorporated into automated or manual sample preparation workflows, with the resulting data used to directly assess complete sample-to-data workflows and provide harmonization and benchmarking between laboratories and techniques. Data are available via PRIDE with identifier PXD013608.
Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells
Authors: Cervantes-Madrid Diana , Szydzik Joanna , Lind Dan Emil , Borenäs Marcus , Bemark Mats , Cui Jean , Palmer Ruth Helen , Hallberg Bengt 
Published: December 2019

AbstractNeuroblastoma is the most commonly diagnosed extracranial tumor in the first year of life. Approximately 9% of neuroblastoma patients present germline or somatic aberrations in the gene encoding for anaplastic lymphoma kinase (ALK). This increases in high-risk neuroblastomas, which have a 14% frequency of ALK aberrations at the time of diagnosis and show increasing numbers at relapse. Abrogating ALK activity with kinase inhibitors is employed as clinical therapy in malignancies such as non-small cell lung cancer and has shown good results in pediatric inflammatory myofibroblastic tumors and anaplastic large cell lymphomas. A phase I clinical trial of the first generation ALK inhibitor, crizotinib, in neuroblastoma patients showed modest results and suggested that further investigation was needed. Continuous development of ALK inhibitors has resulted in the third generation inhibitor repotrectinib (TPX-0005), which targets the active kinase conformations of ALK, ROS1 and TRK receptors. In the present study we investigated the effects of repotrectinib in a neuroblastoma setting in vitro and in vivo. Neuroblastoma cell lines were treated with repotrectinib to investigate inhibition of ALK and to determine its effect on proliferation. PC12 cells transfected with different ALK mutant variants were used to study the efficacy of repotrectinib to block ALK activation/signaling. The in vivo effect of repotrectinib was also analyzed in a neuroblastoma xenograft model. Our results show that repotrectinib is capable of inhibiting signaling activity of a range of ALK mutant variants found in neuroblastoma patients and importantly it exhibits strong antitumor effects in a xenograft model of neuroblastoma.
Only vulnerable adults show change in chronic low-grade inflammation after contemplative mental training: evidence from a randomized clinical trial
Authors: Puhlmann Lara M. C. , Engert Veronika , Apostolakou Filia , Papassotiriou Ioannis , Chrousos George P. , Vrtička Pascal , Singer Tania 
Published: December 2019

AbstractGrowing evidence suggests that chronic low-grade inflammation can be reduced through mindfulness-based mental training interventions. However, these results are inconsistent and based on patient populations with heterogeneous conditions. Similar research in healthy adults is lacking. Moreover, common intervention protocols involve varying combinations of different contemplative practices, such that it remains unclear which types of training most effectively influence biomarkers of inflammation. The present study investigated the effect of three distinct 3-month training modules cultivating a) interoception and present-moment focus (Presence), b) socio-affective skills (Affect), or c) socio-cognitive skills (Perspective) on the inflammatory biomarkers interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) in 298 healthy adults. We observed no group-level effect of training on either biomarker, but trend-level interactions of training type and participant sex. In additionally exploring the influence of participants’ baseline inflammation, a selective training effect emerged: Following the Presence module, participants with relatively higher inflammatory load showed stronger reduction in IL-6 on average, and in hs-CRP if they were male. Mindfulness- and attention-based mental practice thus appears most effective when targeting chronic low-grade inflammation in healthy adults, particularly in men. Overall, our data point to a floor effect in the reduction of inflammatory markers through contemplative mental training, suggesting that mental training may be less effective in improving basal biological health outcomes in healthy, low-stressed adults than in vulnerable populations.
Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson’s disease mouse model
Authors: Ji Robin , Smith Morgan , Niimi Yusuke , Karakatsani Maria E. , Murillo Maria F. , Jackson-Lewis Vernice , Przedborski Serge , Konofagou Elisa E. 
Published: December 2019

AbstractFocused ultrasound-enhanced intranasal (IN + FUS) delivery is a noninvasive approach that utilizes the olfactory pathway to administer pharmacological agents directly to the brain, allowing for a more homogenous distribution in targeted locations compared to IN delivery alone. However, whether such a strategy has therapeutic values, especially in neurodegenerative disorders such as Parkinson’s disease (PD), remains to be established. Herein, we evaluated whether the expression of tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine catalysis, could be enhanced by IN + FUS delivery of brain-derived neurotrophic factor (BDNF) in a toxin-based PD mouse model. Mice were put on the subacute dosing regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), producing bilateral degeneration of the nigrostriatal pathway consistent with early-stage PD. MPTP mice then received BDNF intranasally followed by multiple unilateral FUS-induced blood-brain barrier (BBB) openings in the left basal ganglia for three consecutive weeks. Subsequently, mice were survived for two months and were evaluated morphologically and behaviorally to determine the integrity of their nigrostriatal dopaminergic pathways. Mice receiving IN + FUS had significantly increased TH immunoreactivity in the treated hemisphere compared to the untreated hemisphere while mice receiving only FUS-induced BBB opening or no treatment at all did not show any differences. Additionally, behavioral changes were only observed in the IN + FUS treated mice, indicating improved motor control function in the treated hemisphere. These findings demonstrate the robustness of the method and potential of IN + FUS for the delivery of bioactive factors for treatment of neurodegenerative disorder.
Complex couplings between joints, muscles and performance: the role of the wrist in grasping
Authors: Caumes Mathieu , Goislard de Monsabert Benjamin , Hauraix Hugo , Berton Eric , Vigouroux Laurent 
Published: December 2019

AbstractThe relationship between posture, muscle length properties and performance remains unclear, because of a lack of quantitative data. Studies on grasping tasks suggested that wrist position could favour the extrinsic finger flexor in regards to their length to maximise grip force performance. The present study aimed at providing quantitative evidence of the links between wrist posture, muscle capacities and grip capabilities. It combines experimental measurements and a musculoskeletal model including the force-length relationship of the four prime muscles used in grasping. Participants exerted their maximum grip force on a cylindrical dynamometer in four different wrist postures, including one freely chosen by participants (spontaneous). A musculoskeletal model computed the muscle force level and length from motion capture and muscle activation. Results revealed that participants exerted maximum grip force spontaneously, with a loss of force when using other postures. At muscle force and length level, grip force variation seems to be associated with all the muscles under study. This observation led to a first quantitative link between power grip, posture and muscle properties, which could provide more insight into neuromechanical interaction involved when grasping. The design of ergonomic devices could also benefit from this quantification of the relationship between wrist angle and muscle length properties.
DTI Study on Brain Structure and Cognitive Function in Patients with Chronic Mountain Sickness
Authors: Bao Haihua , Li Ruiyang , He Mingli , Kang Dongjie , Zhao Lili 
Published: December 2019

AbstractIn chronic mountain sickness (CMS) patients, the structure of the brain, memory and cognition are often irreversibly damaged by chronic hypoxia due to red blood cell overcompensation, elevated haemoglobin and blood stasis. In this study, we aimed to evaluate this damage using diffusion tensor imaging (DTI) and to study the correlations among the fractional anisotropy (FA),the apparent diffusion coefficient (ADC) value, the severity index of CMS and the simple Mental State Examination (MMSE) score in CMS patients. A total of 17 patients with CMS and 15 healthy controls were recruited for conventional brain magnetic resonance imaging (MRI) and DTI scans, and ADC images were reconstructed along with FA and FA colour maps. The FA and ADC values of the selected regions of interest (ROIs) were measured and compared. The FA and ADC values were also compared with the haemoglobin (Hb) and MMSE scores. CMS patients are prone to intracranial ischaemia, infarction and haemorrhage. Multiple structural changes occur in the brain of CMS patients, and these changes are related to the severity of the disease and cognitive function variation. The white matter fibre bundles of CMS patients showed no obvious damage, except in the ischaemic site.
Nature of novel criticality in ternary transition-metal oxides
Authors: Abdulvagidov Shapiullah B. , Djabrailov Shamil Z. , Abdulvagidov Belal Sh. 
Published: December 2019

AbstractThere are the chains of transition-metal cations alternating with the anions of oxygen in ternary transition-metal oxides. When a p-orbital of the oxygen connects the half-filled and empty d-orbitals of adjacent transition-metal cations, double-exchange ferromagnetism takes place. Although double exchange has been well explored, the nature of novel criticality, induced by it, is yet not uncovered. We explored the magnetic-field scaling in the heat capacity of a Sm0.55Sr0.45MnO3 manganite, one of the best ternary transition-metal oxides as it is completely ferromagnetic, and found novel criticality - unordinary critical exponents which are the consequence of coherence of Coulomb lattice distortion and ferromagnetism. The coherence is caused by the trinity of the mass, the charge and the spin of an electron. When the d and p orbitals overlaps, it quickly walks from one site to the another due its lightest mass. And due to its electric charge, it equalizes the valences of the transition-metal cations in the chains and so diminishes the Coulomb lattice distortion. At last, its spin forces magnetic moments of transition-metal cations to ferromagnetically arrange. The disappearance of Coulomb distortions widens the overlap and lowers the elastic lattice energy, so that not only the spin of an electron, but also its electric charge strengthens ferromagnetism. That nonlinear effect strengthens the critical behaviour and critical exponents come off any known universality classes. Thus, the symbiotic coherence of annihilating Coulomb distortions and arising ferromagnetism is a reason of the novel criticality.
One-step synthesis of gold and silver non-spherical nanoparticles mediated by Eosin Methylene Blue agar
Authors: Lomelí-Rosales Diego Alberto , Zamudio-Ojeda Adalberto , Cortes-Llamas Sara Angélica , Velázquez-Juárez Gilberto 
Published: December 2019

AbstractNowadays, there are several approaches reported to accomplish the green synthesis of metal nanoparticles by using bacterial and fungi supernatants or by-products generated by these microorganisms. Therefore, agars as solely reductive regents have started to be used in order to obtain metal nanoparticles. This paper shows the results of the synthesis of gold and silver nanoparticles with different morphology, mainly triangular and truncated triangular, using Eosin Methylene Blue (EMB) agar as reducing agent. To control the reaction process, the necessary activation energy for the reducer was provided by three different techniques: microwave radiation, using a domestic microwave oven, ultraviolet radiation, and heating on a conventional plate. The evolution of the reduction process and stability of the samples was performed by ultraviolet visible spectroscopy. Morphology was carefully analyzed using high-resolution transmission electron microscopy (HRTEM) and Transmission electron microscopy (TEM). A one step synthesis for gold and silver nanoparticles was optimized with an eco-friendly and economic process.