bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Method to Classify and Subgroup Patients With IBS Based on Gastrointestinal Symptoms and Psychological Profiles
Authors: Black Christopher J. , Yiannakou Yan , Guthrie Elspeth A. , West Robert , Houghton Lesley A. , Ford Alexander C. 
Published: October 2020

INTRODUCTION:
Conventionally, patients with irritable bowel syndrome (IBS) are subgrouped based on their predominant bowel habit. Given the relevance of psychological comorbidity to IBS symptoms, our aim was to explore an alternative approach to subgrouping by incorporating factors beyond stool form and frequency.

METHODS:
We collected demographic, symptom, and psychological health data from 1,375 adult subjects in the community who self-identified as having IBS, identifying 2 cohorts meeting either Rome III or Rome IV criteria. In each cohort, we performed latent class analysis, a method of model-based clustering, to identify specific subgroups (clusters). For each cluster, we drew a radar plot and compared these by visual inspection, describing cluster characteristics.

RESULTS:
In total, 1,080 individuals met the Rome III criteria for IBS, and 811 met the Rome IV criteria. In both cohorts, a 7-cluster model was the optimum solution, and the characteristics of the clusters were almost identical between Rome III and IV. Four clusters were defined by the pattern of gastrointestinal symptoms (loose stools and urgency or hard stools and bloating), further differentiated by the presence of abdominal pain not relieved by defecation, and by the extent of psychological comorbidity. Two clusters had below-average gastrointestinal symptoms, differentiated by the extent of psychological comorbidity. The final cluster had well-above-average gastrointestinal symptoms and high levels of psychological comorbidity. The proportion of subjects with severe IBS symptom scores, high levels of perceived stress, and high levels of gastrointestinal symptom–specific anxiety was significantly higher in clusters with high psychological comorbidity (P < 0.001).

DISCUSSION:
Latent class analysis identified 7 distinct IBS subgroups characterized by varying degrees of gastrointestinal symptoms, extraintestinal symptoms, and psychological comorbidity. Further research is needed to assess whether they might be used to direct treatment.
Sistem Informasi Wisata Kuliner di Kota Semarang Berbasis Web
Authors: Ariwardhani Chaerunissa , Rochim Adian Fatchur , Windasari Ike Pertiwi 
Published: October 2020

Kemajuan teknologi informasi dewasa ini memicu pertumbuhan jumlah para pengguna internet. Dalam dunia bisnis, peranan teknologi menjadi hal yang sangat utama, dan bisa dikatakan sudah menjadi kebutuhan primer bagi usahawan pada masa ini. Demikian halnya tentang kuliner yang telah memanfaatkan jaringan internet untuk menyajikan berbagai informasi baik dari informasi tempat, rasa, penyajian dan harga dalam bidang teknologi informasi. Namun untuk informasi kuliner di Semarang dalam sebuah site, sementara ini masih kurang lengkap dan belum ada site yang menkhususkan wisata kuliner di Semarang. Oleh karena itu dibutuhkan sebuah perancangan aplikasi sistem informasi wisata kuliner Kota Semarang berbasis web untuk memudahkan masyarakat dalam menemukan ragam kuliner yang ada di Kota Semarang .Desain dan implementasi akan diawali dengan analisa kebutuhan sistem atau dikenal dengan istilah system requirements analysis. Hal ini ditujukan untuk mendapatkan spesifikasi sistem yang sesuai. Dalam tahapan desain, Data Flow Diagram digunakan untuk penggambaran proses bisnis dengan jelas. Sementara itu, Entity Relationship Diagram digunakan untuk merepresentasikan data dalam sistem secara logis. Hasil dari tahapan desain kemudian diimplementasikan dengan menggunakan bahasa pemrograman PHP dan menggunakan sistem basis data MySQL serta penggunaan Javascript untuk menghasilkan sistem informasi berbasis web yang lebih dinamis Tools yang digunakan adalah software Adobe Dreamweaver CS6, XAMPP.Hasil pengujian Sistem Informasi Wisata Kuliner di Kota Semarang Berbasis Web menunjukkan bahwa semua fitur yang terdapat dalam aplikasi dapat bekerja dengan baik seperti mengelola data kuliner, mengelola data admin, mengelola data member dan mengelola komentar yang masuk. Menggunakan permodelan sistem Entity Relationship Diagram. Sistem informasi ini memiliki user pada sistem sebanyak lima yaitu admin, member aktif, member pasif, member premium dan pengunjung.
Pengenalan Bahasa Inggris untuk Anak Melalui Permainan Edukasi "The Zoo" Berbasis Kinect
Authors: Setyani Fatima , Isnanto R. Rizal , Martono Kurniawan Teguh 
Published: October 2020

Bahasa Inggris sebagai bahasa universal memegang peranan penting dalam kehidupan sehari-hari, namun kemampuan bahasa Inggris masyarakat Indonesia masih tergolong sangat rendah. Pembelajaran bahasa Inggris merupakan upaya untuk mengatasi permasalahan tersebut dan haruslah dimulai sejak dini dengan metode yang menyenangkan. Oleh karena itu dibangunlah permainan “The Zoo” berbasis Kinect sebagai media pengenalan bahasa Inggris untuk anak yang menghadirkan pengalaman interaksi baru terhadap pemain .Permainan “The Zoo” dibangun dari WPF C# project dan menggunakan Kinect SDK versi 1.6. Tahapan perancangan terdiri dari menentukan tujuan dan memilih tema; melakukan riset tema terkait; merancang struktur I/O, struktur pemrograman, dan struktur permainan; pemrograman; pengujian; dan pengambilan umpan balik.Permainan “The Zoo” telah diuji di TK Al Azhar 14 Semarang. Hasil pengujian fungsional dengan metode kotak hitam menunjukkan bahwa permainan ini dapat berjalan dengan baik pada sistem operasi Windows 7 di lingkungan .NET Framework 4.5. Metode pengujian pemain yang digunakan adalah metode eksperimental dimana kelompok eksperimen diberikan perlakuan berupa pembelajaran menggunakan media permainan “The Zoo”. Hasil pengolahan data tes awal dan tes akhir menunjukkan bahwa nilai rata-rata tes akhir kelompok eksperimen lebih tinggi dari kelompok kontrol sehingga dapat disimpulkan bahwa permainan “The Zoo” telah mencapai tujuan awal permainan.a
Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine
Authors: Hörber Sebastian , Peter Andreas , Lehmann Rainer , Hoene Miriam 
Published: October 2020

Abstract

Objectives
Due to its high specificity, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is considered the gold standard in diagnostic areas such as therapeutic monitoring of immunosuppressive drugs (ISDs). However, many laboratories still rely on immunoassays for ISD quantification in a tradeoff between analytical performance and the advantages of fully automated analyzers – shorter turnaround times, greater ease of use, and 24/7 availability.

Methods
The LC-MS/MS-based Thermo Scientific™ Cascadion™ SM Immunosuppressant Panel was evaluated for >6 months in the routine laboratory of a university hospital. We assessed the analytical performance of the panel and compared it to conventional LC-MS/MS as well as to immunoassays (cyclosporine A, sirolimus, tacrolimus (Siemens) and everolimus (Thermo Fisher)). In addition, both ISD panel and Cascadion analyzer were scrutinized with regards to, e.g., turnaround time, usability, and robustness.

Results
All ISDs showed high linearity and precision (CV≤6%) and a good correlation with conventional LC-MS/MS. The mean deviation to the immunoassays was 17–19% and negative for all ISDs except everolimus with a positive 19% bias. No weak points were revealed when challenging assay and system with, e.g., high haematocrit, sedimented whole blood or priority samples. The Cascadion integrated well into our 24/7 routine and could easily be operated simultaneously with several other analyzers by technical staff without LC-MS experience.

Conclusions
The ISD panel showed excellent analytical performance and demonstrated that a fully automated LC-MS-based analysis starting from primary samples is feasible, suggesting that LC-MS could become an integral part of 24/7 diagnostics in the near future.
Clinical performance of calcitonin and procalcitonin Elecsys® immunoassays in patients with medullary thyroid carcinoma
Authors: Giovanella Luca , Fontana Martina , Keller Franco , Verburg Frederik A. , Ceriani Luca 
Published: October 2020

Abstract

Objectives
Medullary thyroid carcinoma (MTC) is caused by a malignant transformation in the parafollicular C-cells of the thyroid, where calcitonin (CT) is released. Nowadays, CT is the main tumor marker used in the diagnosis and follow-up of MTC patients. Nonetheless, procalcitonin (PCT) has recently been proposed as a useful complementary/alternative biomarker in MTC. Our aims were to investigate the diagnostic performance of CT and PCT and their combination in the differential diagnosis between active and inactive MTC and between MTC and non-MTC thyroid diseases, respectively.

Methods
Serum samples were collected from 16 patients with active (i.e. primary tumour before surgery or post-surgical recurrent disease) and 23 with inactive (i.e. complete remission) MTC, 125 patients with non-MTC benign thyroid disease and 62 patients with non-MTC thyroid cancers, respectively. Elecsys® CT and PCT measurements were simultaneously performed on the Cobas e601 platform (Roche Diagnostics, Rotkreutz, Switzerland).

Results
Both CT and PCT median values in active MTC (94 pmol/L and 1.17 ng/mL, respectively) were significantly higher compared with inactive MTC (0.28 and 0.06) and either benign (0.37 and 0.06) or malignant (0.28 and 0.06) non-MTC. Undetectable PCT was found in five non-MTC patients with false positive CT results.

Conclusions
Elecsys® PCT assay is a highly sensitive and specific alternative MTC marker. At the very least it appears useful in patients with positive CT results as negative PCT values securely exclude active MTC. The availability of both markers on the same automated platform facilitates reflex or reflective strategies to refine the laboratory diagnosis.
Mobil4Park: development of a sensor-stimulator network for the therapy of freezing of gait in Parkinson patients
Authors: Dvorani Ardit , Wiesener Constantin , Valtin Markus , Voigt Hanno , Kühn Andrea , Wenger Nikolaus , Schauer Thomas 
Published: October 2020

Abstract
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the world which mainly affects the human’s motor systems. An estimated number of 7–10 million people worldwide suffer from PD. In Germany, the number of people affected by PD lies at about 300,000 and the number rises every year by approximately 13,000. One of the cardinal symptoms of PD is the freezing of gait (FoG), which arises/appears in the late stages of the PD. FoG is defined as an episodic process with increased restriction of movement or complete blockage despite the intention of moving and, as it can lead to falls and injuries and reduces the quality of life, is considered as one of the most disabling symptoms of PD. In this contribution, we introduce a wearable wireless system designed for gait monitoring and non-invasive electrical stimulation (cueing) in case of a FoG episode.
Extravagant “fake” morphemes in Dutch. Morphological productivity, semantic profiles and categorical flexibility
Authors: Van Goethem Kristel , Norde Muriel 
Published: October 2020

AbstractDutch features several morphemes with “privative” semantics that occur as left-hand members in compounds (e.g.,imitatieleer‘imitation leather’,kunstgras‘artificial grass’,nepjuwelen‘fake jewels’). Some of these “fake” morphemes display great categorical flexibility and innovative adjectival uses.Nep, for instance, is synchronically attested as an inflected adjective (e.g.,neppe cupcake‘fake cupcake’). In this paper, we combine an extensive corpus study of eight Dutch “fake” morphemes with statistical methods in distributional semantics and collexeme analysis in order to compare their semantic and morphological properties and to find out which factors are the driving forces behind their exceptional “extravagant” morphological behavior. Our analyses show that debonding and adjectival reanalysis are triggered by an interplay of two factors, i.e., type frequency and semantic coherence, which allow us to range the eight morphemes on a cline from more schematic to more substantive “fake” constructions.
Pyrolysis of corn cob: physico-chemical characterization, thermal decomposition behavior and kinetic analysis
Authors: Singh Sanjay , Sawarkar Ashish N. 
Published: October 2020

Abstract
Bioenergy out of lignocellulosic biomass, especially from agricultural crop residues, is making massive inroads in our quest for sustainable environment. In the present study, detailed physico-chemical characterization, thermal degradation characteristics, and kinetics of pyrolysis of corn cob are reported. Thermogravimetric experiments were performed at different heating rates, such as, 10, 20, and 30 °C/min in an inert atmosphere. Thermogravimetric (TG) and derivative thermogravimetric (DTG) curves inferred the thermal behavior characteristics of corn cob. Significant content of cellulose and hemicellulose put together (76.23%) suggested tremendous potential of corn cob to give enhanced yield of bio-oil through pyrolysis. Maximum mass loss of 61.92% for corn cob was observed in the temperature range of 180–360 °C. The kinetic parameters for pyrolysis of corn cob were determined by employing model-free isoconversional methods like, Kissinger-Akahira-Sunose, Flynn-Wall-Ozawa, and Starink. Activation energy from FWO (62.44 kJ/mol) and Starink (61.74 kJ/mol) method for pyrolysis of corn cob was found to be in close proximity. The results revealed prospective bioenergy potential of corn cob as a feedstock for pyrolysis process.
Radiata pine fretboard material of string instruments treated with furfuryl alcohol followed by tung oil
Authors: Liu Meihong , Lyu Shaoyi , Peng Limin , Lyu Jianxiong , Huang Zhenhua 
Published: October 2020

Abstract
The dimensional instability and inferior mechanical strength of radiata pine (Pinus radiata D. Don) limit its use in musical instruments. To improve its properties, a two-step treatment by furfuryl alcohol (FA) and tung oil (TO) were used involving impregnation of FA precursor solution into the wood matrix, forming a highly cross-linked resin, followed by a modification with TO. Examination using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy revealed that FA resin was attached in cell walls and lumens, and the solidified TO in cell lumens and occluded pits. The incorporation of FA resin reduced the wood swelling coefficient by over 70% and the hydrophobic solidified TO decreased wood water uptake by over 80% enhancing wood dimensional stability. Although FA resin improved the modulus of elasticity and hardness of the wood, the modulus of rupture and impact bending strength were reduced. However, the additional TO impregnation step improved the modulus of rupture, impact bending strength, and wear resistance of the furfurylated wood. The performance of FA and TO treated radiata pine wood was better than that treated with FA or TO alone, and could meet the performance requirements of wood used for fretboard of string instruments.
Quality assessment of teak (Tectona grandis) wood from trees grown in a multi-stratified agroforestry system established in an Amazon rainforest area
Authors: Mascarenhas Adriano Reis Prazeres , Sccoti Marta Silvana Volpato , Melo Rafael Rodolfo de , Corrêa Fernando Luiz de Oliveira , Souza Emanuel Fernando Maia de , Pimenta Alexandre Santos 
Published: October 2020

Abstract
The establishment of agroforestry systems (AFS) is a consistent strategy to integrate sustainable supply of wood, food and environmental services in a single land plot. Teak (Tectona grandis Linn. F.) is an interesting option for the tree component in AFS, though there is a lack of information on its potential. This study aimed to characterize the quality of teak wood produced in an AFS regarding its technological characteristics and best end uses. Wood was sampled from a multi-stratified AFS located in the midwestern region of Rondônia state, Brazil, more specifically in a formerly deforested area of Amazon rainforest. The AFS is composed of double-ranked perennial crops and the forest component has growing space of 5.0 × 2.5 m. Physical-mechanical properties of teak wood were assessed and the results indicated its medium to high dimensional stability along with mechanical performance very close to that determined for wood from either homogeneous plantations or natural forests. Specific strength was significantly higher than some tropical wood species with higher densities. Teak wood from the AFS reached the minimum requirements for structural applications, with suitable properties to be used in the manufacture of decks, partitions and, residential flooring.
MXene/wood-based composite materials with electromagnetic shielding properties
Authors: Wang Zhenxing , Han Xiaoshuai , Wang Sijie , Han Xuewen , Pu Junwen 
Published: October 2020

Abstract
With the growing popularity in digital systems and electronic communication equipment, there is an urgent need to develop lightweight, green, and efficient electromagnetic interference (EMI) shielding materials to handle the increasingly serious problem of radiation pollution. Herein, Ti3C2Tx (MXene)/natural wood (NW) composites were prepared using a vacuum-pulse impregnation method and characterized by Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) patterns, X-ray photoelectron spectroscopy (XPS) analysis, and EMI shielding performance. As demonstrated, Ti3C2Tx nanosheets were successfully inserted into wood matrices, and hydrogen bonding between Ti3C2Tx nanosheets and cellulose nanofibers induced the fabrication of Ti3C2Tx/NW composites. Ti3C2Tx/NW composites exhibited excellent EMI shielding effectiveness (SE) values of 28.2 dB at the X-band frequency.
In-situ penetration of ionic liquids during surface densification of Scots pine
Authors: Neyses Benedikt , Peeters Kelly , Buck Dietrich , Rautkari Lauri , Sandberg Dick 
Published: October 2020

Abstract
The moisture-induced recovery of compressed wood is one of the major problems of wood densification technology. Achieving a cost-efficient surface densification process without the need for additional resins to eliminate the set-recovery may lead to an increase in value of low-density wood species. A previous study has shown that a pre-treatment with ionic liquids (ILs) can nearly eliminate the set-recovery. It was however observed that during the pre-treatment process the IL did not penetrate sufficiently deep into the wood to explain the achieved reduction in set-recovery. Based on these findings, the hypothesis was posed that further penetration of the IL into the wood occurs during the densification stage as a consequence of the applied heat and pressure. Thermo-gravimetric analysis (TGA) and gas-chromatography mass-selective-detection (GC-MSD) showed that the depth of penetration of the IL was greater after the densification process than before. Digital image correlation (DIC) showed that in regions with a high IL concentration, there was almost no set-recovery, and it gradually increased with a decrease in the IL concentration, as observed with TGA and GC-MSD analysis.
Morphological dependent effect of cell-free formed supramolecular fibronectin on cellular activities
Authors: Le Phong , Mai-Thi Hoang-Nghi , Stoldt Volker R. , Tran Ngoc Quyen , Huynh Khon 
Published: October 2020

Abstract
Fibrillar fibronectin (FFN), an active form of fibronectin (FN), plays important roles in various cellular processes. Our goal is to investigate effect of FFN morphology on cellular behaviors. Plasma FN at two concentrations was cross-linked into FFN by dialysis against 2 M urea followed by morphological analysis under Scanning Electron Microscopy. To evaluate effect of FFN morphology, fibroblasts were cultured on FN or different FFNs. Fibroblast behaviors including adhesion, spreading, and migration were evaluated. Our data showed that FN fibrillogenesis was dependent on FN concentration. At high concentrations (0.75 mg/mL), large FFN approximately 2.167 + 0.875 µm in diameter were formed with attached nodular structures and rough surface. In contrast, smooth surface FFN fibrils with diameter of 1.886 + 0.412 µm were formed from FN at 0.25 mg/mL. Cellular assays revealed morphological dependent biological effects of different FFNs. Fibroblast separately adhered to native FN and remained spherical while on FFN, cells attached with higher quantity and showed spreading morphology. A synergistic ligand interaction of integrin α5β1 and αvβ3 was observed in cell adhering on FFN. Cell migration results showed that large FFN decreased migration rate while small FFN did not. Taken together, our data draws new attention towards controlling biological function of FN by its fibrillar structure.
On effects of shape, aspect ratio and position of obstacle on the mixing enhancement in micromixer with hexagonal-shaped chambers
Authors: Gidde Ranjitsinha R. 
Published: October 2020

AbstractThe micromixer geometry presented consists of T-type micromixer with premixing chamber, hexagonal shaped chambers and obstacles. In order to observe influences of obstacle shape, aspect ratio and position, simulations are carried out for two types of obstacle shapes viz. rectangular and triangular for the Reynold number in the range from 0.1 to 75. Flow and mixing dynamics are studied to investigate the effect of geometric modifications for identifying the mixing mechanisms. The effect of obstacle shape, aspect ratio and position is investigated using the performance characteristics viz. mixing index and pressure drop quantitatively. Both the micromixers demonstrate different mixing mechanisms, including transverse flow, vortices and chaotic advection due to split and recombination action. The mixing performance is diffusion dominated below Re < 5 and it is advection dominated beyond Re > 5. At Re ≥ 20, the mixing index observed is 0.80 in all the micromixer design configurations.
Easy removal of nitrate and phosphate anions from water by low cost chitosan and activated charcoal
Authors: Reddy Katlakanti Mohan , Singh Samarth Pratap 
Published: October 2020

AbstractPresence of nitrate and phosphate ions is difficult to remove from the lakes, as they are highly soluble in water. A way of chemical method adopted to remove these ions from the drinking water using the simple method use of naturally abundant chitosan with charcoal. Adsorption of nitrate and phosphate anions from aqueous solution (water/waste water) on both the chitosan and activated charcoal was investigated. In batch mode adsorption study leads to developing efficient low-cost removal method is important to protect the aquatic environment from the high concentration of nitrate and phosphate anions intake as well as adverse effects on human health. The modified chitosan microspheres had a laudable performance for nitrate and phosphate adsorption Use of this material as an adsorbent is a cheaper and biocompatible method. A systematic study of the adsorption of nitrate and phosphate anions on chitosan and activated charcoal was performed by varying the pH, the initial concentration, contact time, and adsorbent dosage. The results demonstrate that the adsorption process was followed adsorption kinetics of both first and second order kinetics when we use of the chitosan and activated charcoal and chitosan is promising for treating water that is contaminated with nitrate and phosphate anions.