bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic toughening effect of hybrid clay particles on poly(lactic acid)/natural rubber blend
Authors: Ahn Jung Hyun , Hong Joung Sook , Ahn Kyung Hyun 
Published: November 2020

AbstractIn this study, poly(lactic acid) (PLA) is toughened by blending with natural rubber (NR). In order to induce additional toughening, the hybrid of two clays (natural clay (CNa+) and organically‐modified clay (C20A)) showing different localization in the blend is added to the PLA/NR 70/30 blend. For the blend with CNa+ localized in the PLA matrix, linear viscoelastic response (G′, G″) of the blend does slightly change with the decreased drop size or the coarsening of NR as CNa+ content increases. On the other hand, the addition of C20A brings notable rheological response with a significant change in morphology from co‐continuous structure (< 0.5 wt%) to compatibilized morphology (> 0.5 wt%). With a small amount of clay (0.75 wt%) where G′ and G″ crossover, the mixture of two clays (CNa+/C20A 0.3/0.45 wt%) inducing different morphologies to the blend causes a synergistic effect to form cocontinuous structure, leading to a synergistic elongation at break over 100%. This study shows that the addition of a small amount of clays less than 1 wt% can induce toughening of PLA/NR by morphology control of well‐designed particle localization. Also, linear viscoelasticity analysis is useful to detect a subtle change in blend morphology.
Integrated simulation for the 2030 agenda†
Authors: Pedercini Matteo , Arquitt Steve , Chan Derek 
Published: November 2020

AbstractThe Sustainable Development Goals (SDGs) of the UN 2030 Agenda are today's global roadmap to sustainable development. Adopted in 2015, the SDGs are the culmination of 50 years of debate and consensus building on the imperatives of sustainable development. The 2030 Agenda explicitly calls for integrated methods for SDG achievement. Two multisector modeling frameworks have emerged to address integration in SDG policy: the system dynamics based Integrated Sustainable Development Goal (iSDG) model and the multimethod International Futures (IFs) model. Both are feedback rich and thoroughly integrated, and we term them as Integrated Systems Models (ISMs). ISMs enable quantification of policy impacts across SDG sectors, helping identify policies that benefit numerous SDGs as well as potential trade‐offs. These benefits have been witnessed in countries where these ISMs have been put to task on SDG policy. As the sustainable development paradigm becomes increasingly integrated, a central role is being created for further development of ISMs. © 2020 System Dynamics Society
Understanding of the Kinetic Stability of cis‐ Isomer of Azobenzenes through Kinetic and Computational Studies
Authors: Das Dhiraj , Yadav Manish K. , Singla Labhini , Kumar Atul , Karanam Maheswararao , Dev Sagarika , Choudhury Angshuman R. 
Published: November 2020

AbstractA library of halogen‐substituted azobenzenes (ABs) have been synthesized and structurally characterized by single crystal X‐ray diffraction technique. Azobenzenes studied herein display fast photo switching properties. Kinetics of cis‐ → trans‐ isomerization has been studied using UV‐VIS spectroscopy and the rate constant for this transformation were determined. Optimization of probable conformers of the cis‐ isomer and the corresponding transition state (TS) were carried out to determine the energy of activation. The Time‐Dependent Density Functional Theory (TD‐DFT) calculations were also performed to gain insight into the photo‐isomerization. Our results indicate that the fluorinated compounds display better kinetic stability of the cis‐ isomer compared to the corresponding chloro and bromo analogues.
Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration
Authors: Cheng Liang , Chen Zhijie , Cai Zhengwei , Zhao Jingwen , Lu Min , Liang Jing , Wang Fei , Qi Jin , Cui Wenguo , Deng Lianfu 
Published: November 2020

AbstractThe ideal bone repair material should firstly recognize and recruit osteoblast precursor cells to initiate the repair process, then promote the differentiation of osteoblasts and accelerate the mineralization of the extracellular matrix (ECM). Here, a bioinspired staged bone regeneration strategy which loads bone morphogenetic protein2 (BMP2)‐modified black phosphorus (BP@BMP2) nanosheets to a polylactic acid (PLLA) electrospun fibrous scaffold, with a combination of recruiting osteoblast precursor cells and biomineralization properties for bone regeneration, is constructed successfully by micro‐sol electrospinning technique. BP, acting as carriers, can not only provide a negative surface and a strong BMP2 loading ability but can also promote biomineralization in a 3D manner on the electrospun fibrous scaffold, while the BMP2 is to target osteoblast precursor cells for recruitment and osteogenesis differentiation, which endows BP@BMP2 nanosheets with staged bone regeneration ability. Furthermore, the in vitro and in vivo data showed that the BP@BMP2 loaded electrospun fibrous scaffold have good biocompatibility and a strong osteogenesis ability resulting in rapid new bone tissue regeneration. Altogether, this newly developed bioinspired BMP2‐modified BP electrospun fiber with staged bone regeneration properties via recruiting osteoblast precursor cells to the bone injured site and accelerating biomineralization can be a promising approach in physiologic bone repair.
Cost risk analysis for instance recommendation in a sustainable Cloud‐cyber‐physical system framework
Authors: Jiang Wenjing , Xu Zichen , Gao Cuiying , Gu Jingyun , Wang Yuhao 
Published: November 2020

AbstractCloud markets advocate powerful instances to take computation over from the cyber‐physical system (CPS). Combining the Cloud and CPS layer, the whole Cloud–CPS framework is designed to achieve both accurate data sensing and fast data analysis. While most researchers trust the computation side, and focus on the actuator in the physical space to ensure the service‐level objectives, SLO, that is, deadline misses, cloud can be a threat to the service sustainability as instance may fail, especially when one tries to make a cost‐effective design. Specifically, users must bear the risk of instance failure. These risks can cause the entire cyber‐physical system to collapse. Our work tackles the cloud aspect of the sustainability challenge from the cloud side in a cloud–CPS framework. We have studied the instance selection problem for the CPS systems, and propose a Cost‐Risk Analysis for Instance Recommendation, or CRAIR, to support a sustainable Cloud–CPS framework. We have adopted the classic risk analysis process from the portfolio management in hedge financial market, combining with the system modeling for the CPS instance selection, as an optimization problem. To solve this problem, we formulate it as a multi‐armed bandit problem and solve it with our upper confidence bound bandit algorithm together, our CRAIR can provide an online risk analysis to maximize the profit with a comparative ratio of O(1+). We have evaluated CRAIR based on simulations using real‐world Google and Alibaba workloads and cloud market numbers. The results show that, compared to traditional approaches, our approach provides the best tradeoff between SLOs and costs. All users achieve their SLOs goals while minimizing their average expenses by 34.6%. By using CRAIR for instance selection, the CPS service can maximize its benefit under a controlled risk.
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway
Authors: Yu Chen‐Lin , Yu Yung‐Luen , Yang Shun‐Fa , Hsu Chung‐En , Lin Chia‐Liang , Hsieh Yi‐Hsien , Chiou Hui‐Ling 
Published: November 2020

AbstractPraeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum praeruptorum Dunn, has been reported to possess anticancer effects against various types of cancer. However, the effect of PA on human hepatocellular carcinoma (HCC) remains uncleared. In this study, our results indicated that PA did not induce cytotoxicity or alter cell cycle distribution in human HCC cells (Huh‐7, SK‐Hep‐1, and PLC/PRF/5 cells). Instead, PA inhibited the migration and invasion of human HCC cells while downregulating the expression of matrix metalloproteinase‐1 (MMP1) and activating the extracellular signal‐regulated kinase (ERK) signaling pathways. Furthermore, blocking the ERK signaling pathway through siERK restored the expression of MMP1 and the invasive ability of PA‐treated HCC cells. In conclusion, our results demonstrate the antimetastatic activity of PA against human HCC cells, supporting its potential as a therapeutic agent of HCC treatments.
N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice
Authors: Naasri Sahar , Helali Imen , Aouni Majoub , Mastouri Maha , Harizi Hedi 
Published: November 2020

AbstractAzoxystrobin (AZO) and Iprodione (IPR) fungicides are extensively used worldwide, and therefore, contaminate all environmental compartments. The toxicity and the mechanisms by which they affected immune cells are complex and remain unknown. This study investigated the impact of AZO and IPR on the in vitro function of mice peritoneal macrophages including lysosomal enzyme activity and tumor necrosis factor (TNF)α and nitric oxide (NO) production in response to lipopolysaccharide (LPS) stimulation, the proliferation of mice splenocytes stimulated by concanavalin (Con)A and LPS, and the production of the Th1cytokine interferon‐gamma (IFNγ) and the Th2 cytokine interleukin (IL)‐4 and IL‐10 by ConA‐activated splenocytes. This is the first report indicating that AZO and IPR fungicides dose‐dependently inhibited mice macrophage lysosomal enzyme activity and LPS‐stimulated production of TNFα and NO. Mitogen‐induced proliferation of mice splenocytes was also suppressed by AZO and IPR in a dose‐dependent manner. More pronounced impact was observed on ConA‐induced response. The production of IFNγ by ConA‐stimulated splenocytes was dose‐dependently inhibited; however, the production of IL‐4 and IL‐10 increased in the same conditions. These results suggested that AZO and IPR polarized Th1/Th2 cytokine balance towards Th2 response. Overall, marked immunosuppressive effects were observed for AZO. The immunomodulatory effects caused by AZO and IPR were partially reversed by the pharmacological antioxidant N‐acetylcysteine (NAC), suggesting that both fungicides exerted their actions through, at least in part, oxidative stress‐dependent mechanism. Collectively, our data showed that AZO and IPR fungicides exerted potent immunomodulatory effects in vitro with eventually strong consequences on immune response and immunologically based diseases.
Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores
Authors: Dodge Hiroko H. , Goldstein Felicia C. , Wakim Nicole I , Gefen Tamar , Teylan Merilee , Chan Kwun C.G. , Kukull Walter A. , Barnes Lisa L. , Giordani Bruno , Hughes Timothy M. , Kramer Joel H. , Loewenstein David A. , Marson Daniel C. , Mungas Dan M. , Mattek Nora , Sachs Bonnie C. , Salmon David P. , Willis‐Parker Monica , Welsh‐Bohmer Kathleen A. , Wild Katherine V. , Morris John C. , Weintraub Sandra ,   National Alzheimer's Coordinating Center (NACC)
Published: November 2020

AbstractIntroductionFederally funded Alzheimer's Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015. We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1.MethodsFirst, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver‐operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests.ResultsSome V3 tests performed better than V2 tests in differentiating between CDR 0.5 and 0, but the improvement was limited to Caucasian participants.DiscussionFurther efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.
MicroRNA‐99 family in cancer and immunity
Authors: Eniafe Joseph , Jiang Shuai 
Published: November 2020

AbstractThe microRNA (miR)‐99 family comprising miR‐99a, miR‐99b, and miR‐100 is an evolutionarily conserved family with existence dating prior to the bilaterians. Members are typically oncogenic in leukemia while their functional roles in other cancers alternate between that of a tumor suppressor and a tumor promoter. Targets of the miR‐99 family rank in the lists of oncogenes and tumor suppressors, thereby illustrating the dual role of this miR family as oncogenic miRs (oncomiRs) and tumor suppressing miRs (TSmiRs) in different cellular contexts. In addition to their functional roles in cancers, miR‐99 family is implicated in the modulation of macrophage inflammatory responses and T‐cell subsets biology, thereby exerting critical roles in the maintenance of tissue homeostasis, establishment of peripheral tolerance as well as resolution of an inflammatory reaction. Here, we review emerging knowledge of this miR family and discuss remaining concerns linked to their activities. A better dissection of the functional roles of miR‐99 family members in cancer and immunity will help in the development of novel miR‐99‐based therapeutics for the treatment of human cancer and immune‐related diseases.This article is categorized under:
RNA in Disease and Development > RNA in Disease
Innovative Governance Model for a Sustainable State-Wide University-Based Telemedicine Program
Authors: Weinstein Ronald S. , Sodhi Nandini , Barker Gail P. , Holcomb Michael J. , Erps Kristine A. , Holtrust Angelette , Latifi Rifat , Krupinski Elizabeth A. 
Published: November 2020

AbstractGovernance of a telemedicine program can influence the sustainability of a state-wide telemedicine program. Concerns of the founding ATP director regarding governance at the University of Arizona’s College of Medicine, in Tucson, 115 miles from the State Capitol in Phoenix, AZ, were addressed by legislative leaders through their creation of the Arizona Telemedicine Council (ATC). This blue-ribbon “non-statutory overarching authority” holds its quarterly 2-hour luncheon meetings in the Board Room of the Joint Legislative Budget Committee on the Arizona State Capitol Campus, in Phoenix. The ATP director creates the ATC meeting agendas. He has moderated all 92 ATC meetings, dating back to October 1996. Chairs of Appropriations Committees in the AZ House of Representatives and AZ State Senate have chaired the meetings. ATC’s meetings provide the opportunity for direct communication between AZ State Legislators, the ATP, and other Arizona stakeholders. This highly visible interest in telemedicine and telehealth on the AZ State Capitol campus, the regularity of ATC meetings, and the free exchange of information among stakeholders has encouraged establishment and success of many high-quality Arizona-based telemedicine programs over the years.
Survey of the Direct-to-Hospital (DTH) Telemedicine and Telehealth Service Industry (2014–2018)
Authors: Weinstein Ronald S. , Rolig Nicholas , Rowe Nancy , Barker Gail P. , Erps Kristine A. , Holcomb Michael J. , Latifi Rifat , Krupinski Elizabeth A. 
Published: November 2020

AbstractThe Arizona Telemedicine Program and its Health Resources and Services Administration (HRSA)-funded telehealth resource center established a Telemedicine/Telehealth Service Provider Directory (SPD) in 2015. This was established in tandem with a national Service Provider Showcase, a direct-to-hospital (DTH) telemedicine service vendor national meeting which helped launch the SPD. The Service Provider Directory (SPD) was designed to provide healthcare system telemedicine service users critical and convenient information about DTH vendors at a single, reliable, web site. The primary aim of this chapter is to analyze the SPD’s database to help characterize the telemedicine/telehealth DTH service industry. As of 2018, 129 DTH companies were listed in the directory (currently 168 companies). Eighty-four percent of companies listed in the SPD as of 2018 indicated they were medical specialty telemedicine service vendors to healthcare systems; 57% were medical specialty telehealth service vendors to non-healthcare systems, such as prisons; and 25% of companies classified themselves as patient education/engagement service providers. The most common telemedicine services, telepsychiatry and tele-mental health, were offered by 44% and 41% of companies, respectively. Remote patient monitoring and mobile health (mHealth) were available from 30% of companies. Targets for marketing of DTH services were rural hospitals (85%), urban/suburban hospitals (75%), and private physician practices, for 65%. Collectively, the 129 DTH telehealth service companies were marketing 70 teleservices and 8 ancillary services in all 50 states. Only 41% of companies said they use an EHR that is ONC certified.
Dressed minimal surfaces in AdS4
Authors: Katsinis Dimitrios , Manolopoulos Dimitrios , Mitsoulas Ioannis , Pastras Georgios 
Published: November 2020

Abstract
We apply an arbitrary number of dressing transformations to a static minimal surface in AdS4. Interestingly, a single dressing transformation, with the simplest dressing factor, interrelates the latter to solutions of the Euclidean non linear sigma model in dS3. We present an expression for the area element of the dressed minimal surface in terms of that of the initial one and comment on the boundary region of the dressed surface. Finally, we apply the above formalism to the elliptic minimal surfaces and obtain new ones.
Notfallmedizin in der Deutschen Gesellschaft zur Rettung Schiffbrüchiger – Auswertung medizinischer Notfälle auf der Nord- und Ostsee über 2 Jahre
Authors: Schemke S. , Schwalbe H. , Grunewald L. , Maurer H. 
Published: November 2020

Zusammenfassung
Hintergrund
Die logistischen Besonderheiten eines maritimen Notfallortes und die häufig zusätzlich drohende akzidentelle Hypothermie machen die Versorgung medizinischer Notfälle auf dem Meer besonders anspruchsvoll. In dieser Arbeit sollen die Charakteristika notfallmedizinischer Einsätze der Deutschen Gesellschaft zur Rettung Schiffbrüchiger (DGzRS) als Hauptträgerin der nichthelikopterbasierten medizinischen Seenotrettung auf den Meeren vor der deutschen Küste beschrieben werden.

Material und Methoden
Es erfolgte eine retrospektive Analyse aller Einsätze der DGzRS der Jahre 2017 und 2018. Die Einsatzdaten und –zeiten sowie die Erkrankungsschwere der Patienten (graduiert mittels NACA-Score) wurden ausgewertet und exemplarisch mit denen eines NEF der Hansestadt Lübeck verglichen.

Ergebnisse
Bei insgesamt 182 medizinischen Einsätzen wurden 224 Patienten behandelt. Die Einsatzeinheiten der DGzRS benötigten im Mittel 30 ± 21 min bis zur Ankunft und 43 ± 30 min für Rettung, Behandlung und Transport. Bei 63 Einsätzen wurden die Patienten durch einen Notarzt betreut, der bei 44 Einsätzen durch die Landrettung herangeführt wurde. Durch die Wartezeit auf bordfremdes Personal wurde bei 26 Einsätzen die Abfahrt um im Mittel 18 ± 7 min verzögert.
Die durchschnittliche Erkrankungsschwere in der Seenotrettung war signifikant höher als im Lübecker Notarztdienst; es gab vergleichbar häufig Reanimationen und Todesfälle.

Schlussfolgerung
Trotz der hohen Krankheitsschwere medizinischer Notfälle auf den Meeren vor Deutschlands Küste treffen Notärzte dort häufig mit erheblicher Verzögerung ein. Es gibt den dringenden Bedarf effektiverer Unterstützung der DGzRS durch für den maritimen Einsatz ausgebildetes ärztliches Personal.
Reactivity of arsenoplatin complex versus water and thiocyanate: a DFT benchmark study
Authors: Tolbatov Iogann , Coletti Cecilia , Marrone Alessandro , Re Nazzareno 
Published: November 2020

AbstractSeven different density functionals, including GGAs, meta-GGAs, hybrids and range-separated hybrids, and considering Grimme’s empirical dispersion correction (M06-L, M06-2X, PBE0, B3LYP, B3LYP-D3, CAM-B3LYP, ωB97X) have been tested for their performance in the prediction of molecular structures, energies and energy barriers for a class of newly developed antitumor platinum complexes involving main group heavy elements such as arsenic. The calculated structural parameters, energies and energy barriers have been compared to the available experimental data. The results show that range-separated hybrid functionals CAM-B3LYP and ωB97X give good results in predicting both geometrical parameters and isomerization energies and barrier heights and are promising new tools for the theoretical study of novel platinum(II) arsenic compounds.
Ultra-processed food consumption patterns among older adults in the Netherlands and the role of the food environment
Authors: Pinho Maria Gabriela M. , Lakerveld Jeroen , Harbers Marjolein C. , Sluijs Ivonne , Vermeulen Roel , Huss Anke , Boer Jolanda M. A. , Verschuren W. M. Monique , Brug Johannes , Beulens Joline W. J. , Mackenbach Joreintje D. 
Published: November 2020

Abstract
Purpose
To describe the patterns of ultra-processed foods (UPFs) consumption in the Netherlands; to test if exposure to the food environment is associated with UPFs consumption; and if this association differed across educational levels and neighbourhood urbanisation.

Methods
Cross-sectional study using 2015-data of 8104 older adults from the Dutch EPIC cohort. Proportion of UPFs consumption was calculated from a validated food-frequency questionnaire. Exposure to the food environment was defined as proximity and availability of supermarkets, fast-food restaurants, full-service restaurants, convenience stores, candy stores and cafés. Consumption of UPFs was expressed as both percentage of total grams and total kilocalories.

Results
The study population was aged 70(± 10 SD) years and 80.5% was female. Average UPFs consumption was 17.8% of total food intake in grams and 37% of total energy intake. Those who consumed greater amounts of UPFs had a poorer overall diet quality. Adjusted linear regression models showed that closer proximity and larger availability to any type of food retailer was associated with lower UPFs consumption (both in grams and kilocalories). Somewhat stronger significant associations were found for proximity to restaurants (β = − 1.6%, 95% confidence interval (CI) = − 2.6; − 0.6), and supermarkets (β = − 2.2%, 95%CI = − 3.3; − 1.1); i.e., Individuals living within 500 m from the closest supermarket, as compared to 1500 m, had 2.6% less calories from UPFs. No differences were found on analyses stratified for urbanisation and education.

Conclusions
Using various measures of exposure to the food environment, we found that exposure to restaurants and supermarkets was associated with somewhat lower consumption of UPFs.