bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neck Lymph Node Metastasis Detection in Patients with Differentiated Thyroid Carcinoma (DTC) in Long-Term Follow-up: a ¹³¹I-SPECT/CT Study
Authors: Spanu Angela , Nuvoli Susanna , Marongiu Andrea , Gelo Ilaria , Mele Luciana , Piras Bastiana , Madeddu Giuseppe 
Published: March 2020

Abstract
Background: The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used 131I-SPECT/CT as a diagnostic imaging procedure.
Methods: A consecutive series of 224 DTC patients with ascertained neck radioiodine-avid foci at ¹³¹I-SPECT/CT during long-term follow-up was evaluated. All patients had already undergone total thyroidectomy and radioiodine therapy and had been classified as follows: 62 at high risk (H), 64 at low risk (L) and 98 at very low risk (VL). ¹³¹I-Whole body scan (WBS) followed by SPECT/CT was performed in all cases.
Results: In the 224 patients, 449 neck iodine avid foci were ascertained at SPECT/CT, while 322 were evidenced at WBS in 165/224 patients. WBS classified as residues 263/322 foci and as unclear 59/322 foci; among the former foci SPECT/CT correctly characterized 8 LN metastases and 3 physiologic uptakes and among the latter, it pinpointed 26 LN metastases, 18 residues, and 15 physiologic uptakes. SPECT/CT also classified 127 foci occult at WBS as 59 LN metastases and 68 residues. Globally, SPECT/CT identified 93 LN metastases in 59 patients (26 H, 20 L, 13 VL), while WBS evidenced 34 in 25 cases. All 13 VL patients, T1aN0M0, 5 of whom with LN near sub-mandibular glands, had thyroglobulin undetectable or <2.5 ng/ml. Globally, SPECT/CT obtained an incremental value than WBS in 45.5 % of patients, a more correct patient classification changing therapeutic approach in 30.3 % of cases and identified WBS false-positive findings in 8% of cases.
Conclusions: ¹³¹I-SPECT/CT proved to correctly detect and characterize neck LN metastases in DTC patients in long-term follow-up, improving the performance of planar WBS. SPECT/CT routine use is thus suggested; its role is particularly relevant in patients with WBS inconclusive, VL, T1aN0M0 and with undetectable or very low thyroglobulin levels.

Keywords: Differentiated thyroid carcinoma (DTC), Neck lymph node metastases, Long-term follow-up, 131I-Whole body scan (WBS), 131I-SPECT/CT
Gingivitis Efficacy of a 0.454% w/w Stannous Fluoride Dentifrice: A 24-week randomized controlled trial.
Authors: Parkinson Charles Richard , MILLEMAN Kimberly R , MILLEMAN Jeffery L 
Published: March 2020

Abstract
Background: Plaque-induced gingivitis can be prevented and treated with regular effective oral hygiene, principally via mechanical cleaning with regular toothbrushing. To complement the mechanical plaque removal, antimicrobial ingredients can be incorporated into dentifrices to inhibit the growth of plaque. This study aimed to evaluate and compare gingivitis and the proportion of subjects moving between gingivitis severity (<10%, >10%<30%, >30% bleeding sites), and plaque reduction, following twice daily use of an experimental non-aqueous 0.454% weight/weight (w/w) stannous fluoride (SnF2) dentifrice, compared to a negative control dentifrice over 12 and 24 weeks.
Method: This was a single-center, examiner-blinded, randomized, stratified, two-treatment arm, parallel group, 24-week clinical study in healthy adult volunteers with moderate gingivitis. At baseline, after abstaining from toothbrushing overnight, subjects underwent MGI (modified gingival index), BI (bleeding index) and PI (plaque index) assessments. Eligible subjects, who met the inclusion/exclusion criteria, were stratified based on gender and baseline mean MGI score (Low ≤2.00 /High >2.00) and randomized to treatment. Following randomization, subjects underwent a thorough dental prophylaxis and flossing. After 12 and 24 weeks of twice daily brushing with their allocated treatment, subjects returned to the site (with overnight plaque, having abstained from oral hygiene procedures for 8 hrs prior to visit) for MGI, BI and PI assessments. Treatment effect was evaluated by comparing the MGI, BI and PI scores.
Results: One hundred and twenty-nine subjects were screened; 98 subjects were randomized and 90 subjects completed the study. Statistically significant differences between treatments, in favour of the 0.454% stannous fluoride dentifrice were observed, compared to the negative control dentifrice, for all outcome measures (MGI, BI, bleeding sites and PI at weeks 12 and 24 p<0.0001). At 24 weeks, 71% of subjects in the 0.453% SnF2 treatment group demonstrated <10% bleeding sites.
Conclusion: A dentifrice containing 0.454% w/w SnF2 was shown to be superior to a standard dentifrice in controlling gingivitis and supra-gingival plaque, over a 24-week period. Over two thirds of subjects in the 0.454% SnF2 treatment group demonstrated a level of bleeding sites potentially representative of “clinical periodontal health” (<10%) following a dental prophylaxis and 24 weeks of product use.
Did the extended coverage policy contribute to alleviating socioeconomic inequality in untreated dental caries of both children and adolescents in South Korea?
Authors: Shin Bo-Mi , Jung Se-Hwang , Kim Myong-Hee , Ryu Jae-In 
Published: March 2020

Abstract
Background Dental sealants have been covered by the National Health Insurance Service (NHIS) since December 2009 in South Korea. This study aims to determine whether the socioeconomic inequality in untreated dental caries decreased after implementing the extended coverage policy for dental sealant.

Methods The data were derived from the fourth (2007–2009) and sixth (2013–2015) waves of the Korean National Health and Nutrition Examination Survey (KNHANES) conducted by the Korea Centers for Disease Control and Prevention (KCDC). Dental caries and sealant experience by income quartiles were tested using the Rao-Scott chi-squared test. In order to examine socioeconomic inequalities and their trends over time, the prevalence ratios (PRs), slope index of inequality (SII), and relative index of inequality (RII) were estimated for each wave and age group. All analyses were conducted using SAS version 9.3.

Results The adjusted PRs of untreated dental caries and sealants in the poorest in the aged 6-11 group were significantly higher and lower, respectively, compared to the most affluent quartile group for the fourth wave; however, all significant differences disappeared for the sixth wave, after the sealant coverage. The gap between the lowest and the highest was similar for the aged 12-18 group but it widened in the untreated dental caries even after the sealant coverage. The statistical significance of the PRs was maintained at the sixth wave for both caries and sealants. Children showed decreases in both SII and RII over time so its significance disappeared. The SII among adolescents decreased over time but the RII of untreated dental caries increased.

Conclusions This study found that the NHIS coverage expansion of dental care had a positive effect on overall status in dental health among children and adolescents. However, younger children benefited more in terms of inequalities. Our findings indicate that strategies to enhance access to preventive dental services should consider the differential effects for the vulnerable population in terms of socioeconomic status and age from the beginning stage of the policy. The extended coverage policy should continue, focusing on the underprivileged and young children population.
Evaluation of personal protection afforded by repellent-treated sandals against mosquito bites in south-eastern Tanzania.
Authors: Sangoro Peter Onyango , Gavana Tegemeo , Finda Marceline , Mponzi Winfrida , Hape Emmanuel , Limwagu Alex , Govella Nicodem J. , Chaki Prosper , Okumu Fredros O. 
Published: March 2020

Abstract
Background Outdoor and early evening mosquito biting needs to be addressed if malaria elimination is to be achieved. While indoor-targeted interventions such as insecticide-treated nets and indoor residual spraying remain essential, complementary approaches that tackle persisting outdoor transmission are urgently required to maximize the impact. Major malaria vectors principally bite human hosts around the feet and ankles. Consequently, this study investigated whether sandals treated with efficacious spatial repellents can protect against outdoor biting mosquitoes. Methodology Sandals affixed with hessian bands measuring 48cm 2 treated with 6 ml, 10 ml and 12 ml of transfluthrin were tested in large cage semi-field and full field experiments. Sandals affixed with hessian bands measuring 240cm 2 and treated with 10 ml and 12ml of transfluthrin were also tested semi field experiments. Human landing catches (HLC) were used to assess reduction in biting exposure by comparing proportions of mosquitoes landing on volunteers wearing treated and untreated sandals. Sandals were tested against insectary reared Anopheles arabiensis mosquitoes in semi-field experiments and against wild mosquito species in rural Tanzania. Results In semi-field tests, sandals fitted with hessian bands measuring 48cm 2 and treated with 12 ml, 10ml and 6ml transfluthrin reduced mosquito landings by 45.9%, (95% confidence interval (C.I.) = 28–59%), 61.1% (48%–71%), and 25.9% (9% - 40%) respectively compared to untreated sandals. Sandals fitted with hessian bands measuring 240cm 2 and treated with 12 ml and 10ml transfluthrin reduced mosquito landings by 59% (43 - 71%) and 64% (48 - 74%) respectively. In field experiments, sandals fitted with hessian bands measuring 48cm 2 and treated with 12 ml transfluthrin reduced mosquito landings by 70% (60% - 76%) against Anopheles gambiae s.l and 66.0% (59% - 71%) against all mosquito species combined. Conclusion Transfluthrin-treated sandals conferred significant protection against mosquito bites in semi-field and field settings. Further evaluation is recommended for this tool as a potential complimentary intervention against malaria. This intervention could be particularly useful for protecting against outdoor exposure to mosquito bites. Additional studies are necessary to optimize treatment techniques and substrates, establish safety profiles and determine epidemiological impact in different settings.
Prevalence of violence and associated factors among Youth in Northwest Ethiopia: Community-based Cross-sectional study.
Authors: Geremew Alehegn Bishaw , Gelagay Abebaw Addis , Bisetegn Telake Azale , Habitu Yohannes Ayanaw , Abebe Solomon Mekonen , Biru Eshetie Melese , Mekonen Temiro Azanaw , Ayele Yilikal Tiruneh , Yeshita Hedija Yenus 
Published: March 2020

Abstract
Background Violence as a known serious public health problem affects people in all stages of life, from childhood to the elderly. In society, one of the most visible forms of violence is young people violence, whereas they, adolescents and young adults, are the main victims of such violence. There was limited information on the burden of violence and factors among this age group. Therefore, this study aimed to determine the prevalence of violence and its associated factors among youth in Northwest, Ethiopia.Methods A community-based cross-sectional study design was conducted to estimate the magnitude of violence among youth in Northwest, Ethiopia. The calculated sample size was 1765. A structured and pretested interviewer administered questionnaire was used to collect the data. A multi-stage cluster sampling technique was employed to get the study participants. Data were entered using Epi Info version 7 and then exported to STATA 14 for data analysis. The bivariate logistic regression model was employed to identify associated factors. An adjusted odds ratio with a 95% confidence interval was used to determine factors associated with violence. Results From the total 1765 representatives of the youth population, 1597 (90.5%) youth participated in the study. Overall, the prevalence of violence among youth aged 15–24 years for the last 12 months was 21.5%. In the multivariate logistic regression model, factors significantly associated with violence were being married and divorced (AOR= 1.77, 95% CI: 1.13, 2.79) and (AOR=5.67, 95%CI: 2.93, 10.99), respectively, Living with mother’s only (AOR= 1.85, 95% CI: 1.28, 2.66) and father’s only (AOR=2.45, 95% CI: 1.30, 4.63), and substance use (AOR= 2.38, 95% CI: 1.56, 3.66).Conclusions The prevalence of violence among youth was high compared to other studies. Special emphasis should be given to reduce the burden of youth violence and preventing and controlling the identified factors by modifying the existing policies/strategies or developing new strategies and interventions program. Keywords: Violence, Youth, Physical violence, Sexual violence, Psychological violence
Factors associated with changing behaviour for arboviruses prevention: evidence from a quasi-experimental intervention study using mobile devices.
Authors: Santos Silvana , Smania-Marques Roberta , Albino Victor Alves , Fernandes Izabelly Dutra , Mangueira Francisco Fernandes Abel , Olinda Ricardo , Bond Carol S , Matheson David , Traxler John 
Published: March 2020

Abstract
Background: Dengue was reintroduced in Brazil in the 80’s. Since 2010, it is estimated that there have been over a million cases of dengue per year, leading to hundreds of deaths. Community health education is one of the main objectives of vector control policies.Objective: Here we compare perceptions and behaviours before and after an educational intervention based on behavioural change theories (BCT) of a group of Endemic Disease Control Agents (ACEs) with a group of college students of Campina Grande city, Paraiba state, Brazil.Methods: Using a distance-learning platform adapted for mobile devices, the intervention consisted of tasks or missions that were presented through short videos with people performing the desired target behaviour. To demonstrate the accomplishment of the tasks, participants produced videos and shared on social networks. A questionnaire was completed before and after the intervention by 58 participants, 31 students and 27 ACEs. Results: Most of the participants were female (83.9% and 72.2% of college students and ACEs, respectively); 27.8% of ACEs attended higher education and 70.4% were married contrasting with 9.8% of the students. Among college students, a significant difference in the chi-square test was found for all ten-target behaviours after the intervention. ANOVA analysis showed that ACEs have a higher perception of susceptibility and more fear of acquiring arboviruses than students do; and there was a correlation between facilitating behaviours with behaviour change. Conclusion: Intervention based on BCT thus contributed to bring students' behaviour patterns closer to those of ACEs.
Time to Prostate-Specific Antigen Nadir After Radical Prostatectomy – a new potential predictive prognostic parameter and its impact on clinical outcomes
Authors: Tran Minh Dac , Moretti Kim L , O'Callaghan Michael E 
Published: March 2020

Abstract
BackgroundTo investigate and validate previously published associations between time to prostate-specific antigen nadir and the time-to-nadir after radical prostatectomy with biochemical recurrence and to extend this analysis to overall survival and prostate cancer-specific mortality risk. MethodsThis is a retrospective analysis of 1796 men from the South Australian Prostate Cancer Clinical Outcomes Collaborative database treated with radical prostatectomy between 1998-2018 with available prostate-specific antigen nadir data within 1-6 months after surgery. Uni- and multivariable analyses of prostate-specific antigen nadir, time-to-nadir, biochemical recurrence and death were performed with Cox and competing risks models (adjusted for age, surgery year, tumour features and preoperative prostate-specific antigen).ResultsThe univariable analysis demonstrated those with shorter time-to-nadir <3 months had a decreased risk of biochemical recurrence (log-rank, p=0.0098) compared to those with longer time-to-nadir 3-6 months. For men with a time-to-nadir <3 months, a Log-rank test showed a decreased risk of prostate cancer-specific mortality (p=0.026) compared to time-to-nadir 3-6 months, without a difference in overall survival. Multivariable competing risk analyses indicated that biochemical recurrence was more likely when time-to-nadir was 3-6 months compared to <3 months (sHR=1.43, CI 1.01-2.02, p=0.04).ConclusionsAmong men undergoing radical prostatectomy, a shorter post-operative time-to-nadir <3 months is associated with decreased risk of biochemical recurrence compared to time-to-nadir 3-6 months. Following adjustment for confounders and competing risks, there was no significant difference in time-to-nadir for mortality outcomes.
Diabetic acute ischaemic stroke patients have an increase in glycemic variations assessed by continuous glucose monitoring: a multi-center, observational study
Authors: Xu Han-rong , Wu Zheng-gang , Li Feng-fei , Lu Guo , Gong Xiao-qian , Guan Xue-neng 
Published: March 2020

Abstract
Background One-third of acute ischaemic stroke (AIS) occurs in patients with an abnormal glucose metabolism, but little is known the differences in glycemic variations (GV) between stroke patients with and without abnormal glucose metabolism. The objective of this study was to observe the differences in GV between AIS patients with T2D and without T2D using continuous glucose monitoring (CGM). Methods This was a multi-center, prospective, observational study performed between March 2018 and September 2018 in 5 hospitals in China. After admission, all recruited patients were subjected to a consecutive 4-day CGM. At the endpoint, patients were divided into two groups according to the T2D status. The primary outcome was the differences in GV between AIS patients with and without T2D. Results A total of 149 patients (63 patients with T2D and 86 patients without T2D) were recruited into this study. AIS patients with T2D had a significant increase in the standard deviation of mean glucose, the mean amplitude glycemic excursions, the mean lowest glucose, the incremental area over the curve of hypoglycemia, the percentage of time spent in hypoglycemia, and the time in target range compared to those AIS patients without T2D (p<0.05 for all). Conclusions Our data demonstrates that AIS patients with T2D had a significant increase in GV compared to those without T2D. Our results indicated that therapies aimed to improvement in GV may be important to a better clinical outcome in patients with AIS after the onset of a stroke.
Relationship between cerebral hemodynamics, tissue oxygen saturation, and delirium in patients with septic shock: a pilot observational trial
Authors: Feng Qing , Ai Meilin , Huang Li , Peng Qianyi , Ai Yuhang , Zhang Lina 
Published: March 2020

Abstract
Background Patients with septic shock are prone to have impaired cerebral autoregulation and to have an imbalance in cerebral oxygen metabolism. Transcranial doppler (TCD) and tissue oxygen saturation monitoring were performed to observe the changes in cerebral hemodynamic indices of the middle cerebral artery, and in cerebral and peripheral tissue oxygen saturation (StO 2 ) to identify risk factors for sepsis-associated delirium (SAD). Methods Patients with septic shock that were admitted to the Department of Critical Care Medicine of Xiangya Hospital of Central South University from May 2018 to March 2019 were prospectively enrolled, which were divided into an SAD group and a non-SAD group according to the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Both groups were compared with respect to patient characteristics, blood gas analysis indexes, organ function indicators, cerebral hemodynamic index, cerebrovascular automatic regulation function (transient hyperemia response rate, THRR index), the changes in regional cerebral oxygen saturation, and peripheral tissue oxygen saturation. Results The incidence of SAD was 39% (20/51). The overall 28-day mortality rate was 43% (22/51). Compared with the non-SAD group, patients in the SAD group required a longer mechanical ventilation time (5 days [95% confidence interval (CI) 2, 6] vs 1day [95% CI 1, 4], p=0.015) and ICU stay (9 days [95% CI 5, 20] vs 5 days [95% CI 3, 9], p=0.042) and has a higher 28-day mortality rate(65% vs 29%, p=0.011).Multivariate regression analysis showed that the THRR index (OR=5.770, 95% CI:1.222-27.255; p=0.027)and mean value of regional cerebral oxygen saturation (rSO 2 ) <55% (OR=3.864, 95% CI:1.026-14.550;p=0.046) were independent risk factors for SAD. Conclusions SAD has a high incidence in septic patients and is associated with poor prognosis. Our results provide a clinical basis for improving early detection and treatment of SAD.
Elevated Blood Urea Nitrogen are associated with Recurrence of post-operative Chronic Subdural Hematoma
Authors: Wang Ning , Hu Jiangnan , Oppong-Gyebi Anthony , Zhu Xuanhao , Li Yihao , Yang Jianjing , Zhuge Qichuan , Ruan Linhui , Ye Sheng 
Published: March 2020

Abstract
BACKGROUND Chronic subdural hematoma (CSDH) is fundamentally treatable with about 2-31% recurrence rate. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence. METHODS A total of 661 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 < Q2 ≤ 4.9 mmol/L, 4.9 < Q2 ≤ 6.4 mmol/L, Q4 > 6.4 mmol/L). Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence. RESULTS CSDH recurrence was observed in 97(14.8%) cases. Significant distinctions were observed between recurrence and non-recurrence groups in BUN quartiles of cases ( P =0.004). After adjusting for the potential confounders, the odds ratio of recurrence was 3.124 (95%CI =1.509–6.468, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. In multiple-adjusted spline regression, high BUN level visually showed significantly high OR value of recurrence risk. CONCLUSIONS Elevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may be served as a risk factor for CSDH recurrence.