bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Healing of Wind Turbine Blades by Pressurized Delivery of Healing Agent
Authors: Shen Rulin , Ren Meijian , Amano Ryoichi S. , Long Mingjun , Gong Yanling 
Published: January 2020

Abstract
Self-healing is a promising way to solve the difficulty in wind turbine blades repair, yet the embedded healing agent may have a disadvantage because of being exposed to outdoor for a long time. Pressurized delivery of the healing agent in real-time when the blade is damaged may be the solution to avoid the disadvantage healing agent. In this paper, the healing agent was pumped to the damaged area by a peristaltic pump, and the healing effect was evaluated by the recovery rate of the residual flexural strength after impact and the image of ultrasonic C-scan. To evaluate the healing effect of different damage degrees, 10 J, 15 J, 20 J, and 25 J impact energies were applied. The fluid tracer test showed that the healing agent could penetrate in the damaged areas after the impact of 15 J, 20 J and 25 J, while the three-point bending test revealed that the healing efficiency was the highest with 20 J (85.2%). The ultrasonic C-scan and optical photos of the sample showed that the images of the healing area were almost consistent with those of the un-impacted area, indicating that the damaged area is healed well. Based on the success of plate samples, the self-healing of the wind turbine blade-scale prototype was then carried out. Twenty-joule impact was exerted on the blade prototype, and the healing agent was pumped to the damaged area using the peristaltic pump similar to the same procedure as that of the plate specimen. Ultrasonic C-scan and optical images of the damaged area showed that the prototype was healed well in comparison with those of the plate specimens, indicating that the application of pressurized delivery of the healing agent system in the self-healing of wind turbine blade prototype was successful.
Using Thermal Shock to Transform Thermal Energy Into Work
Authors: Tileubay Zhengis 
Published: January 2020

Abstract
This article discusses the use of thermal shock to transform thermal energy into work. A new concept in understanding the laws of conversion of thermal energy into mechanical energy is presented. The relevance of the research in this direction is substantiated. The potential thermodynamic effectiveness of this process is determined. It presents higher efficiency compared with the traditional methods of converting heat into work based on the expansion of the working material. This article describes the method and the algorithm of the experiment to determine the operational capability of thermal shock and shows the predicted results of the experiments. The possibility to construct a completely new thermal engine with an efficiency of close to 100% is also mentioned.
Thermodynamic Study on Blends of Hydrocarbons and Carbon Dioxide as Zeotropic Refrigerants
Authors: Yelishala Sai C. , Kannaiyan Kumaran , Wang Ziyu , Metghalchi Hameed , Levendis Yiannis A. , Sadr Reza 
Published: January 2020

Abstract
Finding alternative refrigerants is of extreme importance to mitigate anthropogenic climate change. Among the next-generation refrigerants, hydrocarbons (HCs) are of technical interest because they are natural, efficient, have low global warming potential (GWP), and zero ozone depletion potential (ODP). However, their flammability impedes their widespread usage for fire-safety reasons. The present work investigated zeotropic mixtures of hydrocarbons with carbon dioxide (CO2) as refrigerants for a simple vapor-compression refrigeration cycle, since their flammability risks are lower than those of pure hydrocarbons. Refrigerants were selected utilizing various screening steps based on environmental effects (such as GWP, ODP, and toxicity), thermophysical properties (such as critical temperature, and boiling point), and mixture data availability. The thermodynamic analysis for these selected zeotropic mixtures was performed for a cycle with a constant temperature of energy (heat) transfer fluid in both the evaporator and the condenser/gas cooler. Subsequently, performance parameters like the coefficient of performance and volumetric refrigeration capacity were compared for each of these blends at different operating conditions, and thus, the most promising hydrocarbon mixtures with CO2 were identified. As a result, the following four hydrocarbons, individually blended with CO2, were favorable in performance: propylene, dimethyl ether, propane, and isobutane. Further analysis was performed to determine the non-dimensional exergy destruction by the various components of the cycle.
FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy
Authors: Brun Francesca , Gigli Marta , Graw Sharon L , Judge Daniel P , Merlo Marco , Murray Brittney , Calkins Hugh , Sinagra Gianfranco , Taylor Matthew RG , Mestroni Luisa , James Cynthia A 
Published: January 2020

BackgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease that affects predominantly the right ventricle and is part of the spectrum of arrythmogenic cardiomyopathies (ACMs). ARVC is a genetic condition; however, a pathogenic gene variant is found in only half of patients.ObjectiveFilamin C gene truncations (FLNCtv) have recently been identified in dilated cardiomyopathy with ventricular arrhythmia and sudden cardiac death, a phenotype partially overlapping with ARVC and part of the ACM spectrum. We hypothesised that FLNCtv could be a novel gene associated with ARVC.MethodsOne hundred fifty-six patients meeting 2010 ARVC Task Force Criteria and lacking variants in known ARVC genes were evaluated for FLNC variants. Available family members were tested for cosegregation.ResultsWe identified two unique FLNCtv variants in two families (c.6565 G>T, p.Glu2189Ter and c.8107delG, p.Asp2703ThrfsTer69), with phenotypes of dominant RV disease fulfilling ‘definite’ diagnosis of ARVC according to the 2010 Task Force Criteria. Variants in other cardiomyopathy genes were excluded in both kindreds, and segregation analysis revealed that p.Asp2703ThrfsTer69 was a de novo variant. In both families, the disease phenotype was characterised by prominent ventricular arrhythmias and sudden cardiac arrest.ConclusionThe identification of FLNCtv as a novel cause of ARVC in two unrelated families expands the spectrum of ARVC non-desmosome disease genes for this disorder. Our findings should prompt inclusion of FLNC genetic testing in ARVC to improve diagnostic yield and testing of at-risk relatives in ARVC.
Maximal efficiency of the collisional Penrose process with spinning particles in Kerr-Sen black hole
Authors: Liu Yunlong , Zhang Xiangdong 
Published: January 2020

AbstractWe study the collision of two uncharged spinning particles around an extreme Kerr-Sen black hole and calculate the maximal efficiency of the energy extraction from the Kerr-Sen black hole via super Penrose process. We consider the collision of two massive particles as well as collision of a massless particle with a massive particle. We calculate the maximum efficiency for all the cases, and found that the efficiency increases as the Kerr-Sen black hole’s parameter ($$b=1-a$$b=1-a) decreases.
Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Authors: Asem Marwa , Young Allison M. , Oyama Carlysa , Claure De La Zerda Alejandro , Liu Yueying , Yang Jing , Hilliard Tyvette S. , Johnson Jeffery , Harper Elizabeth I. , Guldner Ian , Zhang Siyuan , Page-Mayberry Toni , Kaliney William J. , Stack M. Sharon 
Published: January 2020

Abstract
The noncanonical Wnt ligand Wnt5a is found in high concentrations in ascites of women with ovarian cancer. In this study, we elucidated the role of Wnt5a in ovarian cancer metastasis. Wnt5a promoted ovarian tumor cell adhesion to peritoneal mesothelial cells as well as migration and invasion, leading to colonization of peritoneal explants. Host components of the ovarian tumor microenvironment, notably peritoneal mesothelial cells and visceral adipose, secreted Wnt5a. Conditional knockout of host WNT5A significantly reduced peritoneal metastatic tumor burden. Tumors formed in WNT5A knockout mice had elevated cytotoxic T cells, increased M1 macrophages, and decreased M2 macrophages, indicating that host Wnt5a promotes an immunosuppressive microenvironment. The Src family kinase Fgr was identified as a downstream effector of Wnt5a. These results highlight a previously unreported role for host-expressed Wnt5a in ovarian cancer metastasis and suggest Fgr as a novel target for inhibition of ovarian cancer metastatic progression.
Significance: This study establishes host-derived Wnt5a, expressed by peritoneal mesothelial cells and adipocytes, as a primary regulator of ovarian cancer intraperitoneal metastatic dissemination and identifies Fgr kinase as novel target for inhibition of metastasis.
Cyclic Guanosine Monophosphate and Risk of Incident Heart Failure and Other Cardiovascular Events: the ARIC Study
Authors: Zhao Di , Guallar Eliseo , Vaidya Dhananjay , Ndumele Chiadi E. , Ouyang Pamela , Post Wendy S. , Lima Joao A. , Ying Wendy , Kass David A. , Hoogeveen Ron C. , Shah Sanjiv J. , Subramanya Vinita , Michos Erin D. 
Published: January 2020

Background

Cyclic guanosine monophosphate (
cGMP
) is a second messenger regulated through natriuretic peptide and nitric oxide pathways. Stimulation of
cGMP
signaling is a potential therapeutic strategy for heart failure with preserved ejection fraction (
HF
p
EF
) and atherosclerotic cardiovascular disease (
ASCVD
). We hypothesized that plasma
cGMP
levels would be associated with lower risk for incident
HF
p
EF
, any
HF
,
ASCVD
, and coronary heart disease (CHD).

Methods and Results

We conducted a case–cohort analysis nested in the
ARIC
(Atherosclerosis Risk in Communities) study. Plasma
cGMP
was measured in 875 participants at visit 4 (1996–1998), with oversampling of incident
HF
p
EF
cases. We used Cox proportional hazard models to assess associations of
cGMP
with incident
HF
p
EF
,
HF
,
ASCVD
(
CHD
+stroke), and
CHD
. The mean (
SD
) age was 62.4 (5.6) years and median (interquartile interval)
cGMP
was 3.4 pmol/
mL
(2.4–4.6). During a median follow‐up of 9.9 years, there were 283 incident cases of
HF
p
EF
, 329 any
HF
, 151
ASCVD
, and 125
CHD
. In models adjusted for
CVD
risk factors, the hazard ratios (95%
CI
) associated with the highest
cGMP
tertile compared with lowest for
HF
p
EF
,
HF
,
ASCVD
, and
CHD
were 1.88 (1.17–3.02), 2.18 (1.18–4.06), 2.84 (1.44–5.60), and 2.43 (1.19–5.00), respectively. In models further adjusted for N‐terminal‐proB‐type natriuretic peptide, associations were attenuated for
HF
p
EF
and
HF
but remained statistically significant for
ASCVD
(2.56 [1.26–5.20]) and
CHD
(2.25 [1.07–4.71]).

Conclusions

Contrary to our hypothesis, higher
cGMP
levels were associated with incident
CVD
in a community‐based cohort. The associations of
cGMP
with
HF
or
HF
p
EF
may be explained by N‐terminal‐proB‐type natriuretic peptide, but not for
ASCVD
and CHD.
A re-examination of the taxonomic status of Prostoma jenningsi—a Freshwater Nemertean
Authors: QUIGG SIOBHAN MARIE , LOWE CHRISTOPHER NATHAN , BUTT KEVIN RICHARD , MITCHAM TIMOTHY , IYENGAR ARATI 
Published: January 2020

Prostoma jenningsi was first recorded at the Clay ‘Ole pond in Lancashire, UK, in 1969 and was distinguished histologically from other Prostoma by the presence of 11 proboscidial nerves (with all other Prostoma species thought to have 9-10). P. jenningsi was considered to be the only species endemic to Lancashire and listed in the British Red Data Book as ‘Insufficiently Known’ as well as a ‘Species of Principal Importance’ under the UK Natural Environment and Rural Communities Act (2006). A limited number of Prostoma spp were recovered from the Clay ‘Ole in 2011 (the first confirmation of the presence of Prostoma spp. since 1999). In 2015, further sampling was undertaken and expanded to other ponds in Lancashire resulting in the discovery of Prostoma spp. at a further 3 locations. Thereafter, DNA sequencing of nuclear 18S ribosomal RNA and mitochondrial Cytochrome Oxidase I (COI) genes were undertaken and phylogenetic analyses performed to establish the taxonomic status of recovered specimens. All available Prostoma sequences (Prostoma eilhardi and Prostoma graecense) were downloaded from GenBank® and Barcode of Life Data System (BOLD) databases for comparison. All 18S sequences from samples in Lancashire were identical to each other and to all downloaded Prostoma sequences, allowing no further analyses. With COI, 50 individuals were collected from 4 locations across Lancashire and sequenced, comparing a total of 480 base pairs. Average uncorrected p-distances between UK and European samples were low, although some more geographically distant samples from California, USA, displayed higher uncorrected p-distance values. Results suggest that the Prostoma recovered from the Clay ‘Ole (and all other sampled locations in Lancashire) are not distinct from P. eilhardi and P. graecense (as downloaded from GenBank® and BOLD) suggesting that there is a strong case for the species status of P. jenningsi to be revoked. Further regional and national sampling is required to obtain a clearer evaluation of the distribution of Prostoma and the levels of genetic diversity present in the UK. In addition, results from this study indicate that thorough taxonomical re-evaluation of species within the Prostoma genus is required.
A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations
Authors: Ersözlü Tolga , Gultekin Erdogan 
Published: January 2020

Objective: We aimed to evaluate the effect of autologous platelet-rich plasma gel (PRPG) on fat graft myringoplasty (FGM) in tympanic membrane perforations caused by chronic otitis media. Methods: This retrospective study involved 63 patients who underwent operations between 2015 and 2018. Fat graft myringoplasty was performed with the transcanal approach with and without the use of PRPG in the surgical field. The patients were classified into 2 groups: group A, which included 32 patients who underwent FGM with the use of autologous PRPG, and group B, which included 31 patients who underwent FGM alone. Tympanic membrane perforations were divided into 2 groups: small perforations (1-2 mm) in a single quadrant and large perforations (2-4 mm) in at least 2 quadrants. Results: Both groups were statistically matched regarding age and sex. The mean postoperative follow-up was 11.6 and 12.1 months for groups A and B, respectively. Four months postoperatively, the success rate of the graft in group A (100%) was significantly higher than that in group B (83.8%; P = .03). The preoperative and postoperative median air–bone gaps of the groups were similar ( P = .653 and P = .198, respectively). No worsening of the air–bone gap was noted postoperatively in either group. Conclusions: This study demonstrated that autologous PRPG application during FGM allows for a higher success rate than FGM alone. Furthermore, the use of PRPG with FGM for large perforations increases the success rate. Further studies are needed to investigate the PRPG healing effect on other tympanic membrane perforation closure techniques.
An Effective Model of Diabetes Care and Education: Revising the AADE7 Self-Care Behaviors®
Authors:   American Association of Diabetes Educators
Published: January 2020

Purpose The AADE7 Self-Care Behaviors® (AADE7) is a robust framework for self-management of diabetes and other related conditions, such as prediabetes and cardiometabolic diseases. It is the position of the American Association of Diabetes Educators (AADE) that, at the cornerstone of diabetes self-management education and support, the AADE7 is the framework for achieving behavior change that leads to effective self-management through improved behavior and clinical outcome measures. The AADE7 model guides the health care team in effective person-centered collaboration and goal setting to achieve health-related outcomes and improved quality of life. Continued research and evidence are critical to expand this model and broaden its application to other chronic conditions. Given the advances in the science of diabetes management, as well as in diabetes self-management education and support, AADE has evaluated the AADE7 within the framework of these advances, including the digital and dynamic health care landscape. Conclusion This revised position statement blends the updates in research and AADE’s vision and expansion beyond diabetes to refresh the AADE7 framework. This revision reflects the perspectives of all members of the health care team as they problem solve with individuals who are at risk for or who have diabetes and related conditions to achieve healthier outcomes.
Acute Hepatocellular Injury Associated With Azithromycin
Authors: Ellison Carolyn A. , Blackwell Sarah B. 
Published: January 2020

Purpose: A report of acute azithromycin-induced hepatocellular injury is described. Summary: An 83-year-old male was admitted with possible community-acquired pneumonia and received azithromycin and ceftriaxone. After 2 doses of azithromycin, the patient’s aspartate aminotransferase and alanine aminotransferase were greater than 3 times the upper limit of normal and continued to rise with subsequent doses. A diagnostic abdominal ultrasound revealed hepatomegaly. Total bilirubin remained within normal limits during the course. Rosuvastatin and fenofibrate were held on admission and were not resumed in the setting of elevated liver enzymes. Rivaroxaban was held in the setting of worsening renal function. Hepatitis serologies were negative. Liver enzymes, international normalized ratio (INR), and activated partial thromboplastin time (aPTT) continued to climb until hospital day 5 when azithromycin was discontinued in response. Liver enzymes, INR, aPTT, and lactate dehydrogenase all decreased from hospital days 6 through 8. Conclusion: A potentially serious liver injury occurred with the initiation of azithromycin and began to resolve quickly after its discontinuation. While cholestatic injury with azithromycin is well described, this is only the third reported case of direct hepatocellular injury.
Indigenous Australians with autism: A scoping review
Authors: Bailey Benjamin , Arciuli Joanne 
Published: January 2020

Aboriginal and Torres Strait Islander people with autism spectrum disorder, used interchangeably with the term autism, are among the most marginalised people in Australian society. This review maps out existing and emerging themes in the research involving Indigenous Australians with autism based on a search of the peer-reviewed and grey literature. Our search identified 1457 potentially relevant publications. Of these, 19 publications met our inclusion criteria and focused on autism spectrum disorder diagnosis and prevalence, as well as carer and service provider perspectives on autism, and autism support services for Indigenous Australians. We were able to access 17 publications: 12 journal articles, 3 conference presentations, 1 resource booklet and 1 dissertation. Findings suggest similar prevalence rates for autism among Indigenous and non-Indigenous Australians, although some Aboriginal and Torres Strait Islander people with autism may not receive a diagnosis or may be misdiagnosed. Research on the perspectives of Aboriginal and Torres Strait Islander carers and Indigenous and non-Indigenous service providers is discussed in relation to Indigenous perspectives on autism, as well as barriers and strategies to improve access to diagnosis and support services. Although not the focus of our review, we briefly mention studies of Indigenous people with autism in countries other than Australia. Lay Abstract Aboriginal and Torres Strait Islander people with developmental disabilities such as autism are among the most marginalised people in Australian society. We reviewed research involving Indigenous Australians with autism based on a search of the peer-reviewed and grey literature. Our search identified 1457 potentially relevant publications. Of these, 19 publications were in line with our main areas of inquiry: autism spectrum disorder diagnosis and prevalence, carer and service provider perspectives on autism, and autism support services. These included 12 journal publications, 3 conference presentations, 1 resource booklet and 1 thesis dissertation. Findings suggest similar prevalence rates for autism among Indigenous and non-Indigenous Australians, although some Aboriginal and Torres Strait Islander people with autism may not receive a diagnosis or may be misdiagnosed. We also discuss research on the perspectives of Aboriginal and Torres Strait Islander carers and Indigenous and non-Indigenous service providers, as well as barriers and strategies for improving access to diagnosis and support services.
Identification of an Autophagy-Related Signature Predicting Overall Survival for Papillary Thyroid Carcinoma
Authors: Hu Gang , Feng Hong-fang , Zhan Hui 
Published: January 2020

Background: Papillary thyroid carcinoma usually shows an excellent prognosis. However, its recurrence or persistence rate is high. In this study, we used bioinformatics to identify autophagy-related genes (ARGs) and establish a novel scoring system for papillary thyroid carcinoma. Methods: We collected ARGs sequencing data of patients with papillary thyroid carcinoma from The Cancer Genome Atlas database. Differentially expressed ARGs were identified by the “Limma” package in R language. After univariate and multivariate Cox regression analysis, an ARG signature was developed. The established prognostic signature was evaluated by Kaplan-Meier curve and time-dependent receiver operating characteristic. Results: A sum of 26 differentially expressed ARGs were identified. Gene set enrichment analysis revealed that several significantly oncological signatures were enriched, such as autophagy, p53 signaling pathway, apoptosis, human cytomegalovirus infection, and platinum drug resistance. After univariate and multivariate analysis, 3 ARGs ( ITPR1, CCL2, and CDKN2A) were selected to develop autophagy-related signature. Patients with high risk had significantly shorter overall survival than those with low risk. The areas under the curve indicated that the signature showed good accuracy of prediction. Conclusions: We established a novel scoring system based on 3 ARGs, which provides a promising tool for the development of personalized therapy.
Accuracy of washout rate analysis for thallium-201 single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors: A phantom study
Authors: Ishihara Masaru , Onoguchi Masahisa , Shibutani Takayuki 
Published: January 2020

Objective The aim of this study was to assess the accuracy of washout rate (WOR) analysis for thallium-201 chloride (201Tl) single-photon emission computed tomography myocardial perfusion imaging data acquired using cadmium zinc telluride detectors and a myocardial phantom. Methods A myocardial phantom was injected with 10.5 MBq 201Tl, and 10-min acquisitions were performed at 0, 24, 46, and 62 h to accommodate natural radioactive decay over time. Global myocardial WOR (global-WOR) and regional WOR (regional-WOR, left anterior descending artery [LAD], right coronary artery [RCA], and left circumflex artery [LCX]) were analyzed between 0 and 24 h (infarction model), 0 and 46 h (ischemia model), and 0 and 62 h (normal model), respectively. We compared the calculated radioactive decay-rate as a reference standard and phantom imaging WOR (phantom-WOR). Results Decay-rate versus phantom-WOR were 20.4% vs. 20.8% (global-WOR), 21.3% (LAD), 21.2% (RCA), and 19.7% (LCX) for the infarction model; 35.4% vs. 35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA), and 35.2% (LCX) for the ischemia model; and 44.5% vs. 45.1% (global-WOR), 45.4% (LAD), 44.7% (RCA), and 43.5% (LCX) for the normal model. Conclusion WOR analysis for 201Tl single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors is a reliable analysis method.