bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitudes and practices on influenza vaccination during pregnancy in Quito, Ecuador
Authors: Erazo Carlos E. , Erazo Carlos V. , Grijalva Mario J. , Moncayo Ana L. 
Published: December 2020

Abstract
Background: Vaccination is the most effective way to prevent infection and severe outcomes caused by influenza viruses in pregnant women and their children. In Ecuador, the coverage of seasonal influenza vaccination in pregnant women is low. The aim of this study was to assess the knowledge, attitudes, and practices (KAP) of pregnant women toward influenza vaccination in Quito-Ecuador.Methods: A cross-sectional study enrolled 842 women who delivered at three main public gynecological-obstetric units of the Metropolitan District of Quito. A questionnaire regarding demographics, antenatal care, risk conditions and knowledge, attitudes and practices related to influenza vaccination was administered. We examined factors associated with vaccination using log-binomial regression models.Results: A low vaccination rate (36.6%) against influenza was observed among pregnant women. The factors associated with vaccination included the recommendations from health providers (adjusted PR: 15.84; CI 95% 9.62-26.10), belief in the safety of the influenza vaccine (adjusted PR: 1.53; CI 95% 1.03-2.37) and antenatal care (adjusted PR: 1.21; CI 95% 1.01-1.47). The most common reasons for not vaccinating included the lack of recommendation from health care providers (73.9%) and lack of access to vaccine (9.0%).Conclusions: Health educational programs aimed at pregnant women and antenatal care providers have the most potential to increase influenza vaccination rates. Further studies are needed to understand the barriers of health care providers regarding influenza vaccination in Ecuador.
Screening for Genetic Variants Associated with Cardiovascular Diseases in Patients with Type 2 Diabetes Mellitus
Authors: Ivelina Mihaleva , Maria Mincheva , Mariela Hristova-Savova , Veronika Petkova , Rumen Nikolov , Markova Tzvetanka , Pavlina Gateva , Dimova Ivanka 
Published: December 2020

Abstract
Background

Diabetes mellitus is associated with a wide range of cardiovascular diseases that comprise the largest cause of both morbidity and mortality for the diabetic patients. Our objective was to study the allelic and genotypic frequencies of genetic variants that have shown a strong association with cardiovascular disease in diabetic patients with and without cardiovascular complications and to assess the additional contribution of genetic variation in determining the risk for such complications.
Methods

We have used cardiovascular disease StripAssay kit (Vienna Lab) based on polymerase chain reaction and reverse hybridization. The following mutations were studied: FV G1691A (Leiden), FV H1299R (R2), Prothrombin G20210A, Factor XIII V34L, β-Fibrinogen − 455 G-A, PAI-1 4G/5G, GPIIIa L33P (HPA-1), MTHFR C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q, Apo E2/E3/E4. 36 diabetic patients divided in 2 groups were analyzed: 1) 20 diabetic patients with cardiovascular disease and 2) 16 diabetic patients without cardiovascular disease.
Results

We found higher than population frequency for the following alleles/genotypes – 5.5% for FV Leiden allele, 9.7% for FVR2 allele, 38.9% for β-Fibrinogen genotype − 455G/A, 58.9% for PAI-1 4G allele, 36.1% for ACE D/D genotype. Statistically higher frequency was established for β-Fibrinogen − 455 G-A in the patients with cardiovascular disease compared to non- cardiovascular disease (55% vs. 18.7%).
Conclusions

We detected high frequency of β-Fibrinogen − 455 G/A genotype in diabetic patients, especially in these with cardiovascular disease. Based on its pro-inflammatory role and its connection to possible thrombotic events, patients would benefit from anti-inflammatory treatment.
Treatment of pediatric supracondylar humerus fractures accompanied with pink pulseless hands
Authors: Xie Li-wei , Wang Juan , Deng Zhi-qiang 
Published: December 2020

Abstract
Background: The optimal treatment for pediatric supracondylar humeral fractures accompanied with a pink pulseless hand is controversial. Some clinicians recommend close observation after closed reduction and percutaneous pinning of the fractures, while some recommend surgical exploration if the radial pulse is unpalpable. The present study aimed to analyze the benefits and outcomes of close observation for treating pediatric supracondylar humeral fractures with a pink pulseless hand.Methods: Thirteen consecutive children presenting with a pink pulseless hand following supracondylar humeral fracture were enrolled in this study. Preoperative and postoperative color-flow Duplex ultrasound detection was used to assess brachial artery compromise in most cases. Urgent closed reduction and percutaneous pinning of the fractures were attempted first. Close observation was carried out when the hand was pink and pulseless with an absent radial pulse. Results: Preoperative color-flow Duplex ultrasound showed no disruption of the brachial artery in cases detected. Compression of the artery by the proximal fragment was observed in most cases, with one case of entrapment of the artery between fragments, and thrombus considered in two cases. All cases underwent urgent surgery, after which nine experienced immediate return of the radial pulse. The remaining four without a palpable pulse were managed with close observation and no deterioration of the vascular status was observed; therefore, no surgical exploration was performed. Postoperative color-flow Duplex ultrasound revealed continuity of the artery and rich collateral circulation. Patients completed an average of 4.5 years of follow-up, during which no major complications occurred. All patients achieved excellent limb function.Conclusion: Our study demonstrates that close observation after urgent closed reduction and percutaneous pinning is a sufficient approach for the treatment of pediatric supracondylar humeral fractures accompanied with a pink pulseless hand. Surgical exploration is not necessary as long as the hand is warm and well perfused. Color-flow Duplex ultrasound is beneficial for assessing vascular compromise and determining treatment strategies.
Attitudes of East Tennessee Residents Towards General and Pertussis Vaccination: A Qualitative Study
Authors: Tandy Corinne , Tree Jennifer M. Jabson 
Published: December 2020

Abstract
Background Despite vaccination being one of the safest and most successful public health tools to control infectious diseases, some people still doubt the efficacy and safety of vaccines. In order to address vaccine hesitancy and anti-vaccination sentiment, it is necessary to understand vaccination attitude development and vaccination behaviors. The objective of this project was to qualitatively investigate general vaccination attitudes and behavior with an additional emphasis on pertussis vaccination. Methods To identify factors that influence attitudes toward vaccination and behaviors in East Tennessee, eleven one-on-one interviews were conducted with participants recruited through convenience and purposive sampling. Interview protocol and deductive codes were developed using the Triadic Theory of Influence as a theoretical framework. Interview transcripts were analyzed qualitatively and themes were identified through constant comparison of interviews, considering both deductively and inductively coded data. Results Most participants (8) held positive attitudes towards vaccination. Participants (8) comfortable with vaccinating themselves or their children said they followed recommendations of doctors. Vaccine hesitant participants’ (3) most frequently cited concern was safety and concern about side effects. These participants also reported that they referenced non-academic or professional sources and felt confident about their knowledge of vaccines and diseases. Vaccine hesitant participants had low perception of risk of vaccine-preventable diseases, particularly pertussis. Participants with children reported that friends and family were influential when deciding to vaccinate their children. Conclusions This study identified themes in the attitudes towards vaccination of participants recruited in East Tennessee. We found that risk perception and family and social group attitudes were the primary influences on vaccination decision making. We recommend that future research includes anti-vaccination participants in their research, if possible, and further explore the relationship between perception of one’s own knowledge and health behavior outcomes.
Factors influencing Adolescent Girls and Young Women's participation in a Combination HIV Prevention Intervention in South Africa
Authors: Appollis Tracy McClinton , Duby Zoe , Jonas Kim , Dietrich Janan , Maruping Kealeboga , Abdullah Fareed , Slingers Nevilene , Mathews Catherine 
Published: December 2020

Abstract
Background: For interventions to reach those they are intended for, an understanding of the factors that influence their participation, as well as the facilitators and barriers of participation are needed. This study explores factors associated with participation in a combination HIV prevention intervention targeting adolescent girls and young women (AGYW) aged 15-24-years-old, as well as the experiences of AGYW, intervention implementers, and facilitators in this intervention.

Methods: This study used mixed-methods approach with quantitative household survey data from 4399 AGYW aged 15-24-years-old in six of the ten districts in which the intervention was implemented. In addition, qualitative methods included semi-structured in-depth interviews and focus group discussions in five of the ten intervention districts with 185 AGYW who participated in one or more of the key components of the intervention, and 13 intervention implementers and 13 facilitators.

Results: Findings reveal that almost half of AGYW (48.4%) living in the districts where the intervention took place, participated in at least one of the components of the intervention. For both 15-19-year-olds and 20-24-year-olds, factors associated with increased participation in the intervention included being HIV negative, in school, never been pregnant, and having had a boyfriend. Experiencing intimate partner violence (IPV) and/or sexual violence in the past 12 months was associated with increased levels of participation in the intervention for 20-24-year-olds only. In our analysis of the qualitative data, facilitators to participation included motivating participants to join the interventions through explaining the benefits of the programme. Barriers included misguided expectations about financial rewards or job opportunities; competing responsibilities, interests or activities; family responsibilities including childcare; inappropriate incentives; inability to disrupt the school curriculum and difficulties with conducting interventions after school hours due to safety concerns; miscommunication about meetings; as well as struggles to reach out-of-school AGYW.

Conclusion: Designers of combination HIV prevention interventions need to address the structural barriers to participation so that AGYW can attend without risking their safety and compromising their family, childcare and schooling responsibilities. Strategies to create demand need to include clear communication about the nature and potential benefits of such interventions, and the inclusion of valued incentives.
Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United States
Authors: Liu Xiaoshuang , Xu Xiao , Li Guanqiao , Xu Xian , Sun Yuyao , Wang Fei , Shi Xuanling , Li Xiang , Xie Guotong , Zhang Linqi 
Published: December 2020

Abstract
Background: The widespread pandemic of novel coronavirus disease 2019 (COVID-19) poses an unprecedented global health crisis. In the United States (US), different state governments have adopted various combinations of non-pharmaceutical public health interventions (NPIs), such as non-essential business closures and gathering bans, to mitigate the epidemic from February to April, 2020. Quantitative assessment on the effectiveness of NPIs is greatly needed to assist in guiding individualized decision making for adjustment of interventions in the US and around the world. However, the impacts of these approaches remain uncertain. Methods: Based on the reported cases, the effective reproduction number (B) of COVID-19 epidemic for 50 states in the US was estimated. Measurements on the effectiveness of nine different NPIs were conducted by assessing risk ratios (RRs) between a and NPIs through a generalized linear model (GLM). Results: Different NPIs were found to have led to different levels of reduction in c. Stay-at-home contributed approximately 51% (95% CI 46%-57%), wearing (face) masks 29% (15%-42%), gathering ban (more than 10 people) 19% (14%-24%), non-essential business closure 16% (10%-21%), declaration of emergency 13% (8%-17%), interstate travel restriction 11% (5%-16%), school closure 10% (7%-14%), initial business closure 10% (6%-14%), and gathering ban (more than 50 people) 7% (2%-11%). Conclusions: This retrospective assessment of NPIs on k has shown that NPIs played critical roles on epidemic control in the US in the past several months. The quantitative results could guide individualized decision making for future adjustment of NPIs in the US and other countries for COVID-19 and other similar infectious diseases.
Associations between developmental timing of child abuse and conduct problem trajectories in a UK birth cohort
Authors: Bauer Andreas , Hammerton Gemma , Fraser Abigail , Fairchild Graeme , Halligan Sarah L. 
Published: December 2020

Abstract
Background Although there is strong evidence for a relationship between child abuse and neglect and conduct problems, associations between child abuse experienced at different developmental stages and developmental trajectories of conduct problems have not been examined. We sought to investigate effects of timing of child abuse on conduct problem trajectories in a large UK birth cohort study. Methods We applied latent class growth analysis to identify conduct problem trajectories in the Avon Longitudinal Study of Parents and Children, using parent-rated conduct problems from ages 4-17 years (N=10648). Childhood-only and adolescence-only abuse, in addition to abuse in both developmental periods (‘persistent’ abuse), were assessed by retrospective self-report at age 22 years (N=3172). Results We identified four developmental trajectories: early-onset persistent (4.8%), adolescence-onset (4.5%), childhood-limited (15.4%), and low (75.3%) conduct problems. Childhood-only abuse and ‘persistent’ abuse were associated with increased odds of being on the early-onset persistent and adolescence-onset conduct problem trajectories compared to the low conduct problems trajectory. Adolescence-only abuse was not predictive of trajectory membership. There were no associations between abuse and childhood-limited trajectory membership.Conclusions Early-onset persistent and adolescence-onset conduct problems showed similar patterns of association with abuse exposure, challenging developmental theories that propose qualitative, as opposed to quantitative, differences in environmental risk factors between these trajectories. The results also highlight that childhood-only and ‘persistent’ abuse were more strongly linked to elevated conduct problem trajectories than adolescence-only abuse, and that ‘persistent’ abuse is particularly detrimental.
Seeking Research Questions from Implementers: Considerations for Leveraging Ground Actors Research Needs in the Fight against Malaria in West Africa.
Authors: Amouh Tete Sitou , Ekoye Saidou Malam , Ahanhanzo Césaire Damien , Guiguemdé Tinga Robert , Sombié Issiaka 
Published: December 2020

Abstract
In the Sahel countries of West Africa, malaria remains a public health scourge. To strengthen the fight against malaria, it is imperative to identify weaknesses and possible solutions before programs implementation. This study reports experiences gained from collaboration between decision-makers and researchers from a project undertaken by the World Bank, titled: Malaria and Neglected Tropical Diseases in the Sahel (SM/NTD). The objectives of this World Bank project were to identify bottlenecks in malaria program implementation as well as related research questions they bring up. Questionnaire addressed to National Malaria Control Program managers and prioritization workshops were used as a medium to identify research questions. Identified research questions were implemented in selected countries and the results, as presented in this study showed that priority issues were those related to prevention, governance, drugs, monitoring and evaluation. The first five priority questions were: (1) compliance with drug doses on the second and third days during the seasonal chemoprevention (SMC) campaigns, (2) the contribution of community-based distributors to the management of severe cases of malaria in children under 5 years, (3) the SMC efficacy, (4) artemisinin-based combination therapy (ACTs) tolerance and efficacy according to existing guidelines, and (5) the quality of malaria control at all levels of the health system. In conclusion, this work showed the effectiveness of collaboration between implementers, programs managers, and researchers in identifying research questions. Furthermore, the results of this study will contribute to improving the implementation of malaria control programs across African countries.
Interplate channel layer controls of slip during and after the 2011 Tohoku-Oki earthquake
Authors: Nakata Ryoko , Hori Takane , Miura Seiichi , Hino Ryota 
Published: December 2020

Abstract
There are remarkable differences between the middle and southern segments of the Japan Trench in terms of the seismic and aseismic slips on the plate interface and seismic velocity structures. The large coseismic slip of the 2011 Tohoku-Oki earthquake was limited to the middle segment, yet the observed negative residual gravity anomaly area in the southern segment corresponds to the postseismic slip area of the Tohoku-Oki earthquake. A model can explain the different slip behaviors of the two segments by considering their structural differences. The model indicated that the plate interface in the south was covered with a thick channel layer, as noted by seismic survey imaging, and this layer resulted in the residual gravity anomaly. Numerical simulations that assumed obvious frictional heterogeneity caused by the layer existing only in the south successfully reproduced M9 earthquakes recurring only in the middle, followed by evident postseismic slip in the south. We suggest that, while the layer makes the megathrust less compliant to seismic slip, it promotes aseismic slip following the growth of seismic slip on the fault in an adjacent region.
Muslim scholars and the world of social media: opportunities and challenges
Authors: Sule Muhammad Maga 
Published: December 2020

<p>The paper has examines what is considered dual contributions of the internet based medium of communication in Da’wah. These platforms for social interaction and communication have become medium of spreading Islamic messages by Islamic scholars. The objective of the paper is to analyze how internet related mane of communications and interaction have aided Da’wah. The researchers adopted an explanatory type of research whose aim is to explain a phenomenon of choice. The researchers sourced data from the secondary sources and analyzed them. It is on the basis of such that, the findings of this research have portrayed that social media as medium of social interaction have been adopted as tools for Da’wah which learned Islamic scholars are using to propagate Islam and its teachings. However, the outcomes confirmed that social media have provided a fruitful ground for the germination of cyber space Islamic scholars, people who are not learned but share texts, video and audio containing distorted and misleading information. This has challenged the age long Islamic practice in Islam where any issues regarding Islamic Da’wah and Fatwa are exclusively for the learned Islamic Scholars. The study in addition reveal that what is obtainable on the social media now is, cyber scholars and quick to post or comment on issues that are exclusive the purview of Islamic scholars.</p>
O desejo do amanhã: resenha de "Controle", de Natalia Borges Polesso
Authors: Furtado Pedro Barbosa Rudge 
Published: December 2020

Objetivamos, neste texto, examinar a dinâmica pulsional - entre o Eros e o Tânatos - irradiada pela e forma e pela mensagem do romance Controle, de Natalia Borges Polesso. A partir das noções de pulsão de morte e de vida, relacionadas conflitivamente e sintetizadas pelo filósofo Rogério M. de Almeida (2007), buscamos compreender como a figuração da doença, de larga tradição na literatura, insula Maria Fernanda, personagem principal da narrativa. Com o desaparecimento do transtorno epiléptico da protagonista, no entanto, a narradora expõe-se ao contato vigoroso com a alteridade, vislumbrando o futuro que outrora, quando doente, podia ser imaginado via alucinação. Por meio de ideias Susan Sontag (1984), Paul Ricouer (2007), Sidarta Ribeiro (2019) e do mencionado Rogério M. de Almeida (2007), analisamos a complexa rede afetiva que leva a protagonista a estruturar o porvir mediante a pulsão de vida.