bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint Design with Providers of Clinical Decision Support for Value-Based Advanced Shoulder Imaging
Authors: Brunner Michael C. , Sheehan Scott E. , Yanke Eric M. , Sittig Dean F. , Safdar Nasia , Hill Barbara , Lee Kenneth S. , Orwin John F. , Vanness David J. , Hildebrand Christopher J. , Bruno Michael A. , Erickson Timothy J. , Zea Ryan , Moberg D. Paul 
Published: February 2020

Abstract
Background Provider orders for inappropriate advanced imaging, while rarely altering patient management, contribute enough to the strain on available health care resources, and therefore the United States Congress established the Appropriate Use Criteria Program.
Objectives To examine whether co-designing clinical decision support (CDS) with referring providers will reduce barriers to adoption and facilitate more appropriate shoulder ultrasound (US) over magnetic resonance imaging (MRI) in diagnosing Veteran shoulder pain, given similar efficacies and only 5% MRI follow-up rate after shoulder US.
Methods We used a theory-driven, convergent parallel mixed-methods approach to prospectively (1) determine medical providers' reasons for selecting MRI over US in diagnosing shoulder pain and identify barriers to ordering US, (2) co-design CDS, informed by provider interviews, to prompt appropriate US use, and (3) assess CDS impact on shoulder imaging use. CDS effectiveness in guiding appropriate shoulder imaging was evaluated through monthly monitoring of ordering data at our quaternary care Veterans Hospital. Key outcome measures were appropriate MRI/US use rates and transition to ordering US by both musculoskeletal specialist and generalist providers. We assessed differences in ordering using a generalized estimating equations logistic regression model. We compared continuous measures using mixed effects analysis of variance with log-transformed data.
Results During December 2016 to March 2018, 569 (395 MRI, 174 US) shoulder advanced imaging examinations were ordered by 111 providers. CDS “co-designed” in collaboration with providers increased US from 17% (58/335) to 50% (116/234) of all orders (p < 0.001), with concomitant decrease in MRI. Ordering appropriateness more than doubled from 31% (105/335) to 67% (157/234) following CDS (p < 0.001). Interviews confirmed that generalist providers want help in appropriately ordering advanced imaging.
Conclusion Partnering with medical providers to co-design CDS reduced barriers and prompted appropriate transition to US from MRI for shoulder pain diagnosis, promoting evidence-based practice. This approach can inform the development and implementation of other forms of CDS.
Can Computer-Assisted Total Knee Arthroplasty Support the Prediction of Postoperative Three-Dimensional Kinematics of the Tibiofemoral and Patellofemoral Joints at the Replaced Knee?
Authors: Belvedere Claudio , Tamarri Silvia , Ensini Andrea , Durante Stefano , Ortolani Maurizio , Leardini Alberto 
Published: February 2020

AbstractThe aim of this study was to analyze the extent to which postoperative patellofemoral joint (PFJ) kinematics assessed at 6-month follow-up after total knee arthroplasty (TKA) mimics the intraoperative kinematics after final component implantation. The study hypothesis, already proved in terms of tibiofemoral joint (TFJ) kinematics, is that the intraoperative assessment of PFJ kinematics after component implantation is also capable of predicting postoperative knee kinematics during activities of daily living. Twenty patients selected for TKA with patellar resurfacing were implanted using surgical navigation, including patellar component positioning via a novel computer-assisted procedure. This allowed for intraoperative TFJ and PFJ kinematic assessment after final component implantation. At 6-month follow-up, all patients were contacted for follow-up control; in addition to clinical examination, this implied postoperative kinematics assessments by three-dimensional video fluoroscopy of the replaced knee during standard activities of daily living. Several traditional PFJ, as well as TFJ, rotations and translations were calculated intra- and postoperatively and then statistically compared. Good postoperative replication of the intraoperative measurements was observed for most of PFJ variables analyzed, as well as those for TFJ. Relevant statistical analysis also supported the significant consistency between the intra- and postoperative measurements. Pertaining to the present findings on a statistical basis, intraoperative measurements performed at both TFJ and PFJ kinematics using a surgical navigation system under passive conditions, are predictive of the overall knee kinematics experienced at postoperative follow-ups by the same replaced knees in typical activities of daily living.
Separation of HCM and LQT Cardiac Diseases with Machine Learning of Ca2+ Transient Profiles
Authors: Joutsijoki Henry , Penttinen Kirsi , Juhola Martti , Aalto-Setälä Katriina 
Published: February 2020

Abstract
Background Modeling human cardiac diseases with induced pluripotent stem cells not only enables to study disease pathophysiology and develop therapies but also, as we have previously showed, it can offer a tool for disease diagnostics. We previously observed that a few genetic cardiac diseases can be separated from each other and healthy controls by applying machine learning to Ca2+ transient signals measured from iPSC-derived cardiomyocytes (CMs).
Objectives For the current research, 419 hypertrophic cardiomyopathy (HCM) transient signals and 228 long QT syndrome (LQTS) transient signals were measured. HCM signals included data recorded from iPSC-CMs carrying either α-tropomyosin, i.e., TPM1 (HCMT) or MYBPC3 or myosin-binding protein C (HCMM) mutation and LQTS signals included data recorded from iPSC-CMs carrying potassium voltage-gated channel subfamily Q member 1 (KCNQ1) mutation (long QT syndrome 1 [LQT1]) or KCNH2 mutation (long QT syndrome 2 [LQT2]). The main objective was to study whether and how effectively HCMM and HCMT can be separated from each other as well as LQT1 from LQT2.
Methods After preprocessing those Ca2+ signals where we computed peak waveforms we then classified the two mutations of both disease pairs by using several different machine learning methods.
Results We obtained excellent classification accuracies of 89% for HCM and even 100% for LQT at their best.
Conclusion The results indicate that the methods applied would be efficient for the identification of these genetic cardiac diseases.
Thumb Disability Examination (TDX) as a New Reliable Tool for Basal Joint Arthritis
Authors: Bäcker Henrik C. , Freibott Christina E. , Rizzo Marco , Lee Donald H. , Glickel Steven Z. , Strauch Robert J. , Rosenwasser Melvin P. 
Published: February 2020

Abstract
Background The general assessment of basal joint arthritis (BJA) is limited using the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. This has been shown to be insensitive to pain and disability levels, leading to the development and validation of the thumb disability examination (TDX) as a specific tool for BJA in 2014.
Objective The goal of this study was to evaluate the reliability, sensitivity, and specificity of the TDX score for BJA.
Methods A multicenter BJA database was established in 2007 to collect prospective data. We evaluated the correlation between the TDX score, visual analog pain scale with activity (A-VAS), Eaton–Littler score, and grip strength using a Pearson test. Additionally, we evaluated the pre- and postintervention scores to assess their predictive values.
Results A total of 109 thumbs of 74 patients with TDX scores were evaluated. Females were more commonly affected (75.2%), and the mean age was 65.39 years (standard deviation: 10.04). The majority of participants were white (90.8%). A high correlation between TDX and A-VAS score (Pearson's correlation = 0.520; p < 0.001) and between grip strength (Pearson's correlation = –0.336; p < 0.005) and Eaton–Littler score (Pearson's correlation = 0.353' p < 0.01) was identified. Additionally, when comparing pre- and post-intervention for all treatment groups and for operative intervention, significant differences in TDX scores were observed (both p ≤ 0.01). No significant differences could be identified for DASH score or A-VAS when assessing these same groups.
Conclusion The TDX score correlates to high Pearson's correlation values and p-values, especially in grip strength, Eaton–Littler score, A-VAS score, and pre-/postintervention for all treatment groups combined and when specifically assessing the surgical intervention group. As a result, it can be concluded that the TDX score is a specific tool for the assessment of BJA.
Level of Evidence This is a Level II, prospective comparative study.
Flexor Pollicis Longus Rupture in a Scaphoid Nonunion: A Case Report
Authors: Crepaldi Bruno E. , Andrijich Courtney , Ecker Jeff 
Published: February 2020

Abstract
Background Flexor pollicis longus (FPL) tendon rupture is a rare complication of scaphoid nonunion.
Case Description A fit active 70-year-old woman ruptured her FPL when it abraded on a painless 50-year-old scaphoid nonunion. She had asymptomatic scaphoid nonunion advanced collapse (SNAC) arthritis. At surgery, the sharp mobile volar scaphoid osteophytes were excised and the volar wrist capsule was repaired. A vascularized fat flap based on a perforator of the radial artery was used to augment the volar wrist capsule repair and to create a smooth gliding surface for the FPL. The ruptured FPL tendon was reconstructed with a palmaris longus graft.
Literature Review Complete rupture of the FPL tendon secondary to scaphoid nonunion is a rare complication. It can be easily misdiagnosed because the original injury may be unrecognized or forgotten. A consensus regarding the optimal surgical management has not been reached.
Clinical Relevance The objective of surgery in this case was to restore FPL function and prevent a recurrent rupture. The asymptomatic SNAC arthritis was not treated. No further wrist surgery was required. The patient was asymptomatic with a functioning FPL tendon 4 years after surgery.
Urinary Symptoms and Bladder Dysfunction in Patients with Neuromyelitis Optica Spectrum Disorders: Evaluation with Urodynamics and Management
Authors: Gupta Anupam , Sivaram Alisseril , Krishnan Rashmi , Khanna Meeka 
Published: February 2020

Abstract

Objective To assess lower urinary tract symptoms (LUTSs) in patients with neuromyelitis optica spectrum disorders (NMOSDs) and bladder dysfunction through urodynamics (filling and voiding phase of cystometrography) and management based on findings.

Patients and Methods The study included 42 (34 females) patients admitted to the rehabilitation department. Neurologic evaluation was performed and severity of myelitis was assessed using the American Spinal Injury Association Impairment Scale. All patients underwent urodynamics, and management was based on the findings.

Results Mean age was 34.5 years (range: 11–64 years; standard deviation: 13.1). Twenty-three (54.8%) patients had a first episode of myelitis, whereas 19 patients had relapses (number of episodes varying from 2 to 7). Eleven (26%) patients had increased frequency, 16 (37%) had urgency, 12 (28%) had urge incontinence, 8 (18.6%) had stress incontinence, 22 (52.4%) had nocturia, 31 (72%) had retention of urine, 22 (52.4%) had incomplete evacuation, and 14 (33.3%) patients had mixed urinary complaints. The common urodynamic findings were neurogenic detrusor overactivity (NDO) with detrusor-sphincter dyssynergia (DSD) in 14 (33.3%) patients, NDO without DSD in 8 (19%), and acontractile detrusor in 20 (47.6%). Pharmacotherapy was advised to 22 (52.4%) patients, whereas clean intermittent catheterization (CIC)/self-catheterization was advised to 39 (92.9%) patients.

Conclusions Urinary retention was observed to be the most common urinary complaint in patients with NMOSD followed by NDO with or without sphincter dyssynergia. Urodynamics should be performed in all patients with LUTSs for best management. CIC remains the gold standard for the management of neurogenic bladder dysfunction.
Surgical Wound Complications after Knee Cruciate Ligament Reconstruction in Patients with Atopic Dermatitis
Authors: Yokoe Takuji , Tajima Takuya , Yamaguchi Nami , Morita Yudai , Chosa Etsuo 
Published: February 2020

AbstractAtopic dermatitis (AD), sometimes referred to as eczema, is a common skin disease, and skin barrier dysfunction and immunological disorders are well recognized. However, surgical wound complications after orthopaedic surgery in patients with AD have not been described. This study aimed to report four patients with AD who developed foreign body reactions to FiberWire sutures with or without surgical wound infection (SSI) after knee cruciate ligament reconstruction (CLR). The mean age was 19.8 (range, 16–25) years, and patients 1 and 3 underwent reconstructions of the posterior and anterior cruciate ligament, respectively. At a mean of 7.5 (range, 4–10) weeks postoperatively, discharge from the surgical wound at the tibial side of the fixed graft was identified. All patients were treated with continuous saline lavage and antibiotics; however, their wounds did not heal. Second-look arthroscopy and hardware removal were performed at a mean 12.2 (range, 9–15) months postoperatively. Proliferated granulation tissue surrounding the FiberWire was identified. Intraoperative wound cultures were negative in three of the four patients. Histological examination of the tissues adjacent to the FiberWire revealed a foreign body reaction. All wounds healed immediately after the second surgery. In addition to SSI, foreign body reactions are more likely to occur in patients with AD than in those without AD. Preoperative management of AD by dermatologists and consideration of appropriate suture materials are mandatory to reduce surgical wound complications after knee CLR in patients with AD.
CERVICO-FACIAL HEMANGIOMAS; THE TREATMENT THAT ELUDES US
Authors: Sharma S.M. 
Published: February 2020

AbstractCervicofacial hemangiomas treated from January 2001 to December 2009 was clinically evaluated. This retrospective clinical study consisted of 42 females and 20 males with the age ranged from 20 days to 55 years. The lesions were present with-in first month in 45 patients (72.6%). Two patterns of tumor growth were evident: focal and diffuse. There were 59 focal hemangiomas (80.8%) and 14 diffuse hemangiomas (19.2%). Complications noted at the time of first consultation include residual skin changes in the in 35 patients (56.5%), obstruction of orifices in 14 patients (22.6%), ulceration in 6 patients (9.7%), and infection occurred in 2 patients (3.2%). Overall, there is reduction in size and improvement in color and texture of lesion following intervention in each group. No significant difference in outcome was observed in between groups with respect to change in size and texture. However, improvement in color showed statistically significant difference and combined treatment modality and surgical treatment was found to be better.
EFFECT OF YOGA THERAPY ON BODY MASS INDEX AND OXIDATIVE STATUS
Authors: Kumari N Suchetha , K.M Damodara Gowda , N. Sukesh , L. N Madhu ,   Kathyayani
Published: February 2020

Abstract
Background and Objective: Human beings are under threat from many chronic diseases and life style disorders. A major cause of all these
diseases was found to be improper lifestyle and stress leading to obesity and excessive lipid peroxidation, indicating increased production of reactive oxygen species. Yoga therapy concentrates on purification of body and mind through its integrated holistic approach one can overcome the different kinds of afflictions in life. Hence the present study was undertaken to find out the effect of intervention of yoga therapy in obese individuals.
Materials and Methods: The study was conducted at MRPL ladies club auditorium in the MRPL Township after an informed and written consent from all the participants. The research protocol was approved by institutional ethics committee. The study consisted of forty obese male and female subjects. The changes in Body weight, Body Mass Index, Blood sugar, MDA level and Total antioxidant status was estimated before and after one month of yoga therapy. The data obtained was analyzed using paired't' test.p<0.05 was the level of significance.
Result: There was a significant decline in the Body Weight (p=0.020), BMI (p=0.000), Fasting Blood Sugar (p=0.03) and Post Prandial Blood Sugar (p=0.000) MDA (p=0.000) and significant increase in Total Antioxidant Level (p=0.021) after yoga when compared to that before the yoga therapy.
Conclusion: Yoga therapy is beneficial in maintaining better health by regulating BMI, Oxidative status by improving the biochemical functions of the body and helpful to overcome the complications of obesity.
EFFECT OF ELECTRON BEAM RADIATION ON HEMATOPOIETIC CELLS OF SWISS ALBINO MICE
Authors: Kumari N Suchetha , L.N Madhu 
Published: February 2020

AbstractIonizing radiation which results in the free radical formation and it leads to damage of biological macromolecules such as DNA, proteins, lipids. 36 male Swiss albino mice were used for survival assay, to find out the lethal dose of Electron Beam Radiation. It was found to be 10Gy was the lethal dose for mice. Different dosages (4Gy, 6Gy and 8Gy) of electron beam radiation were used to study the micronucleus formation in irradiated mice. The results showed micronucleus formation will increase linearly with radiation dosage.
EVALUATION OF THE EFFICACY OF CARDAMOM AROMATHERAPY ON AEROBIC FITNESS & AUTONOMIC FUNCTIONS AMONG STUDENTS.
Authors: Patil Shrikant L. , Sreekumaran E. , Krishna A.P. 
Published: February 2020

Abstract
Introduction: Aromatherapy is categorized as a form of complementary and alternative medicine (CAM), and has been steadily gaining popularity in today's society. Aromatherapy is considered by many to promote comfort, well-being and invigorating. However there appears to be insufficient supporting evidence to validate physiological changes that may reflect invigoration.
Objectives: This study examined the physiological effects of cardamom (Elettaria cardamomum) aromatherapy as indicated by heart rate variability. Aerobic fitness is one of the non invasive and simplest parameters which help in accessing one's fitness. In this present study we have also evaluated the efficacy of aromatherapy on the individual's physical fitness.
Methods: Total thirty healthy college students were selected as a subject who has attended four sessions in random order involving only exercise, aromatherapy and exercise combined. Each intervention lasted 15 minutes. Heart rate data were recorded for all sessions, and heart rate variability was analyzed. Aerobic fitness parameters also evaluated with the help of standard methods.
Results: There was statistically significant difference in LF/HF between the two intervention studies. During this aromatherapy, physiological responses such as oxygen consumption, respiratory exchange ratio and minute ventilation were significantly altered among different groups. Aerobic fitness was observed higher in aromatherapy combined exercise group against the only exercise group.
Conclusion: These results suggest significant physiological effect of cardamom (Elettaria cardamomum) aromatherapy interventions occurs in the autonomic nervous system as indicated by heart rate variability. The present study demonstrates that good estimated aerobic fitness was independently associated with aromatherapy and exercise.
RARE DISTINCT SUBTYPE OF CLEAR CELL RENAL CELL CARCINOMA - MULTILOCULAR CYSTIC RENAL CELL CARCINOMA
Authors: K. Jayaprakash Shetty , Makannavar J. H. , H.L Kishan Prasad , P. Rajeev T. ,   Chandrika
Published: February 2020

AbstractMultilocular cystic renal cell carcinoma (MCRCC) is an uncommon low- grade tumor with unique morphologic features and excellent prognosis. Currently it is classified as subtype of clear cell renal cell carcinoma. We report a case of multilocular cystic renal cell carcinoma presented with right renal mass. Computed tomography showed heterogeneously enhancing partly cystic mass lesion in right kidney. Patient underwent right nephrectomy. Microscopic features were suggestive of multilocular cystic renal cell carcinoma. Patient is doing well with no evidence of recurrence.
Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ
Authors: Zhang Shuya , Kim Ji Young , Xu Suowen , Liu Huan , Yin Meimei , Koroleva Marina , Guo Jia , Pei Xiuying , Jin Zheng Gen 
Published: February 2020

Significance
Endothelial sprouting is critical for both physiological and pathological angiogenesis. However, the molecular mechanisms underlying precise regulation of endothelial sprouting have not been fully understood. Here we show that the transcription factor Yin Ying 1 (YY1) functions as a repressor of Notch signaling through its inhibition of the intracellular domain of the Notch protein/mastermind-like protein 1/recombination signal binding protein for Ig Kappa J region complex formation and modulates endothelial cell tip-stalk fate determination. Our results reveal that YY1 plays an important role in regulating endothelial sprouting and angiogenesis and suggest YY1 could be a potential molecular target for angiogenesis-related diseases.
“Stories that are worth spreading”
Authors: Nadeem Nahla 
Published: February 2020

Abstract
The present study aims to provide a conceptualization of how narratives function in TED talks. It uses Bamberg’s
positioning theory as a theoretical framework to build a communicative model of TED Talk narratives. TED narratives are “small
stories” that are told, indeed performed, in the presence of an audience and designed to accomplish particular rhetorical aims.
The model specifically investigates (1) how genre features affect the design and rhetorical aims of TED talk narratives, (2) TED
speaker’s narrative positioning and multi-modal narrative performance, (3) evidence of the audience’s engagement in the narrative
and finally, (4) TED narratives as a scaffold for potential individual and social change. Using a multi-modal discourse analysis
approach, the model is applied to the narratives used in Guy Winch’s TED Talk (Winch, 2015). The model provides an analytical
tool for investigating the dynamic interaction and semiotic signaling involved in the communicative performance of TED Talk
narratives.
Multimodal corpus analysis of subtitling
Authors: Ramos Pinto Sara , Mubaraki Aishah 
Published: February 2020

AbstractThis article proposes a new methodology for multimodal corpus analysis. It does so by particularly focusing on the issue of the translation of non-standard language varieties. This new methodology, which is significantly influenced by the work ofIedema (2003),Jimenez Hurtado and Soler Gallego (2013),Pastra (2008)andRamos Pinto (2018), is capable of identifying the modes and resources at play and the relations identified between them, as well as how such relations participate in the construction of the non-standard varieties’ communicative meaning. It also accounts for the impact of the introduction of subtitles on preserving, cancelling or modifying the intermodal relations identified in the source text and, consequently, the diegetic functions they support; that is, the function they assume in the fictional world of the film. In this regard, the methodology assumes a clear translational perspective.