bluuebunny/crossref_metadata_2025_split huggingface dataset:
A panel of two miRNAs correlated to systolic blood pressure is a good diagnostic indicator for stroke
Authors: Qi Yujun , Yuan Mingfeng , Yi Qiong , Wang Yan , Xu Lei , Xu Changsong , Lu Min 
Published: December 2020

Abstract
Background: We aimed to develop a diagnostic indicator of stroke based on serum miRNAs correlated to systolic blood pressure.
Methods: Using miRNA expression profiles in GSE117604 from the Gene Expression Omnibus (GEO), we utilized the WGCNA to identify hub miRNAs correlated to systolic blood pressure (SBP). Differential analysis was applied to highlight hub differentially expressed miRNAs (DE-miRNAs), whereby we built a miRNA-based diagnostic indicator for stroke using bootstrap ranking Least Absolute Shrinkage and Selection Operator (LASSO) regression with 10-fold cross-validation. The classification value of the indicator was validated with receiver operating characteristic (ROC) analysis in both the training set and test set, as well as quantitative real-time PCR (qRT-PCR) for the feature miRNAs. Further, target genes of hub miRNAs and hub DE-miRNAs were retrieved for functional enrichment.
Results: A total of 447 hub miRNAs in the blue modules were significantly correlated with systolic blood pressure (r = 0.32, false discovery rate = 10−6). Target genes predicted with the hub miRNAs were mostly implicated in the Kyoto Encyclopedia of Genes and Genomes (KEGG) terms including mitogen-activated protein kinase (MAPK) pathway, senescence, and TGF-β signaling pathway. The diagnostic indicator with miR-4420 and miR-6793-5p showed remarkable performance in the training set (area under curve [AUC]= 0.953), as well as in the test set (AUC = 0.894). Results of qRT-PCR validated the diagnostic value of the two miRNAs embedded in the proposed indicator.
Conclusions: We developed a panel of two miRNAs, which is a good diagnostic indicator for stroke. These results require further investigation.
Elevated CDK5R1 predicts worse prognosis in hepatocellular carcinoma based on TCGA data
Authors: Zeng Zhili , Cao Zebiao , Zhang Enxin , Huang Haifu , Tang Ying 
Published: December 2020

AbstractBackground: Hepatocellular carcinoma (HCC) is a malignant tumor with rapid progression, high recurrence rate and poor prognosis. The objective of our investigation was to explore the prognostic value of CDK5R1 in HCC.Methods: The raw data of HCC raw data were downloaded from The Cancer Genome Atlas (TCGA) database. The Wilcoxon signed-rank test, Kruskal–Wallis test and logistic regression were applied to investigate the relevance between the CDK5R1 expression and clinicopathologic characteristics in HCC. Kaplan–Meier and Cox regression analysis were employed to examine the association between clinicopathologic features and survival. Gene set enrichment analysis (GSEA) was applied to annotate the biological function of CDK5R1.Results: CDK5R1 was highly expressed in HCC tissues. The high expression of CDK5R1 in HCC tissues was significantly associated with tumor status (P=0.00), new tumor event (P=0.00), clinical stage (P=0.00) and topography (P=0.00). Elevated CDK5R1 had significant correlation with worse overall survival (OS; P=7.414e−04), disease-specific survival (DSS; P=5.642e−04), disease-free interval (DFI; P=1.785e−05) and progression-free interval (PFI; P=2.512e−06). Besides, univariate and multivariate Cox regression analysis uncovered that increased CDK5R1 can independently predict adverse OS (P=0.037, hazard ratio [HR]= 1.7 (95% CI [1.0–2.7])), DFI (P=0.007, hazard ratio [HR]= 3.0 (95% CI [1.4–6.7])), PFI (P=0.007, hazard ratio [HR]= 2.8 (95% CI [1.3–5.9])). GSEA disclosed that notch signaling pathway and non-small cell lung cancer were prominently enriched in CDK5R1 high expression phenotype.Conclusions: Increased CDK5R1 may act as a promising independent prognostic factor of poor survival in HCC.
Place du Cesa, Centre d’évaluation et de soins pour adolescents, dans le parcours de soin des adolescents déprimés en Seine-et-Marne
Authors: Lacour Gonay Catherine 
Published: December 2020

La spécificité de la prise en charge dans le parcours de soin des adolescents déprimés au Cesa, tient à la prise en compte du symptôme scolaire pour décliner une prise en charge individuelle, ambulatoire, institutionnelle et séquentielle autour d’un projet « soin-étude » individualisé avec le jeune et ses parents.
Retrospective Evaluation of Patients Treated for Ectopic Pregnancy: Experience of a Tertiary Center
Authors: Kömürcü Karuserci Özge , Sucu Seyhun 
Published: December 2020

Abstract
Objective In recent years, there has been an increase in the incidence of ectopic pregnancies; therefore, it is important for tertiary centers to report their approaches and outcomes to expand and improve treatment modalities. The aim of the present study was to evaluate the general characteristics, treatment and outcomes of cases diagnosed with ectopic pregnancy.
Methods In total, 432 patients treated for ectopic pregnancy between February 2016 and June 2019 were retrospectively evaluated.
Results Overall, 370 patients had tubal pregnancy, 32 had cesarean scar pregnancy, 18 had pregnancy of unknown location, 6 had cervical pregnancy, and 6 had interstitial pregnancy. The most important risk factors were advanced age (> 35 years; prevalence: 31.2%) and smoking (prevalence: 27.1%). Thirty patients who did not have any symptoms of rupture and whose human chorionic gonadotropin (β-hCG) levels were ≤ 200 mIU/ml were followed-up with expectant management, while 316 patients whose β-hCG levels were between 1,500 mIU/ml and 5,000 mIU/ml did not have an intrauterine gestational sac on the transvaginal or abdominal ultrasound, did not demonstrate findings of rupture, and were treated with a systemic multi-dose methotrexate treatment protocol. In total, 24 patients who did not respond to the medical treatment, 20 patients whose β-hCG levels were > 5,000 mIU/ml, 16 patients who had shown symptoms of rupture at the initial presentation, and 6 patients diagnosed with interstitial pregnancy underwent surgery. Patients with cervical and scar pregnancies underwent ultrasound-guided curettage, and no additional treatment was needed.
Conclusion The fertility status of the patients, the clinical and laboratory findings, and the levels of β-hCG are the factors that must be considered in planning the appropriate treatment.
Advantages and Disadvantages of Medical Abortion, According to Brazilian Residents in Obstetrics and Gynaecology
Authors: Bento Silvana Ferreira , Pádua Karla Simônia de , Pacagnella Rodolfo de Carvalho , Fernandes Karayna Gil , Osis Maria José Duarte , Duarte Graciana Alves , Faúndes Anibal 
Published: December 2020

Abstract
Objective To find out which was the opinion of residents in obstetrics and gynecology about the advantages and disadvantages of medical abortion as compared with surgical procedures.
Method Cross-sectional multicenter study among residents in obstetrics and gynecology from 21 maternity hospitals located in 4 different geographical regions of Brazil, using a self-responded questionnaire with 31 questions related to their opinion and experience on providing abortion services.
Results Most residents agreed that “being less invasive” (94.7%), “does not require anesthesia” (89.7%), “can be accompanied during the process” (89.1%), “prevents physical trauma” (84.4%) were the main advantages of medical abortion.
Conclusion Residents perceived both clinical and personal issues as advantages of medical abortion.
Conformal symplectic and relativistic optimization
Authors: França Guilherme , Sulam Jeremias , Robinson Daniel P , Vidal René 
Published: December 2020

Abstract
Arguably, the two most popular accelerated or momentum-based optimization methods in machine learning are Nesterov’s accelerated gradient and Polyaks’s heavy ball, both corresponding to different discretizations of a particular second order differential equation with friction. Such connections with continuous-time dynamical systems have been instrumental in demystifying acceleration phenomena in optimization. Here we study structure-preserving discretizations for a certain class of dissipative (conformal) Hamiltonian systems, allowing us to analyse the symplectic structure of both Nesterov and heavy ball, besides providing several new insights into these methods. Moreover, we propose a new algorithm based on a dissipative relativistic system that normalizes the momentum and may result in more stable/faster optimization. Importantly, such a method generalizes both Nesterov and heavy ball, each being recovered as distinct limiting cases, and has potential advantages at no additional cost.
Random matrix improved covariance estimation for a large class of metrics*
Authors: Tiomoko Malik , Bouchard Florent , Ginolhac Guillaume , Couillet Romain 
Published: December 2020

Abstract
Relying on recent advances in statistical estimation of covariance distances based on random matrix theory, this article proposes an improved covariance and precision matrix estimation method for a wide family of metrics. This method is shown to largely outperform the sample covariance matrix estimate and to compete with state-of-the-art methods, while at the same time being computationally simpler and faster. Applications to linear and quadratic discriminant analyses also show significant gains, therefore suggesting a practical relevance for statistical machine learning.
Wide flat minima and optimal generalization in classifying high-dimensional Gaussian mixtures
Authors: Baldassi Carlo , Malatesta Enrico M , Negri Matteo , Zecchina Riccardo 
Published: December 2020

Abstract
We analyze the connection between minimizers with good generalizing properties and high local entropy regions of a threshold-linear classifier in Gaussian mixtures with the mean squared error loss function. We show that there exist configurations that achieve the Bayes-optimal generalization error, even in the case of unbalanced clusters. We explore analytically the error-counting loss landscape in the vicinity of a Bayes-optimal solution, and show that the closer we get to such configurations, the higher the local entropy, implying that the Bayes-optimal solution lays inside a wide flat region. We also consider the algorithmically relevant case of targeting wide flat minima of the (differentiable) mean squared error loss. Our analytical and numerical results show not only that in the balanced case the dependence on the norm of the weights is mild, but also, in the unbalanced case, that the performances can be improved.
Quantitative reasoning and written communication. Competencies that evidence scientific thinking in university graduates
Authors: Ramirez-Leal P 
Published: December 2020

Abstract
The purpose of this manuscript was to characterize and analyse both the differences and similarities of the results between the different careers in a public university in eastern Colombia, in the state tests Saber Pro 2017, in the modules quantitative reasoning and written communication, skills needed to evidence the level of scientific thinking, very useful for professionals in engineering and science, especially for professionals in mathematics and physics. In this research, a univariate descriptive analysis was carried out, followed by a principal component analysis. Engineering programs tend to perform better in quantitative reasoning and those of social sciences and education in written communication. These results indicate that graduates of engineering and science programs have a level of scientific thinking more related to the exact and natural sciences.
Physical-technological change as a competitive factor in the clothing and footwear industry
Authors: Peña-Cáceres O , González Mendoza J , Vergel Ortega M 
Published: December 2020

Abstract
The investigation aimed to analyze the influence of physic-technological change as a factor of competitiveness in the textile and footwear industry in San José de Cúcuta, Colombia. The methodology follows a mixed approach supported by factorial, phenomenological and documentary analysis designs, using instruments such as interviews and surveys, scientific production databases and governmental and trade union reports of the sector. The physic-technological change was conceived by businessmen as a productive process, innovative, of social change, and transformation with associated factors of strategic management, culture of market planning, problem that solves, reach, control of success, materials such as systems based on silicone, polymers, panels and closed air pressure grilles, as well as improvements in sole material and use of recyclable material according to environmental policies, reduction of time of product development, marketing of the invention, resources, management of risk, productivity and competitiveness, depend on type of changes implemented or designed in companies of low, medium or high level and are associated with factor of competitiveness. It is concluded that technological change as a competitiveness factor allows maintaining or increasing market share and endogenous changes in productive and technological systems in the market.
Numerical and experimental study of the 3D flow in a graft-artery junction model
Authors: Ivanova Y F , Yukhnev A D , Gataulin Y A , Smirnov E M , Vrabiy A A , Vavilov V N 
Published: December 2020

Abstract
Vascular graft occlusion after implantation is one of the most urgent problems of vascular surgery. This paper presents results of numerical simulation and ultrasound/strain gauge measurements of the 3D pulsating flow of blood-mimicking fluid in a model of the junction of the graft with superficial femoral artery. The calculations have pointed, in particular, at occurrence of an extensive stagnant zone with low wall shear stresses near the graft-artery junction, which can accelerate the graft occlusion. Both the simulation and the ultrasound measurements have shown that a four-vortex flow structure forms just after the graft-artery junction zone, which transforms into a two-vortex flow structure further downstream. Numerical and experimental data on the pressure drop at the graft-artery junction model were in a good accordance.
The impact of surface boundary conditions on the formation of the Black Sea haline stratification from the numerical simulations
Authors: Senderov M V , Mizyuk A I 
Published: December 2020

Abstract
Following a series of studies of the formation of the Black Sea haline stratification by various initial and boundary conditions, three numerical experiments were performed. For this purpose, the previously performed experiment with a spatially uniform salinity of 12 %º was chosen (experiment 1). New simulations were carried out with heat fluxes on the surface (experiment 2) obtained in the department of VAO FSBSI FRC MHI. In addition to heat fluxes, a constant cyclonic tangential wind stress curl (experiment 3) and a tangential wind stress curl with a seasonal variation (experiment 4) were also set. The results of numerical simulations show that in all experiments where heat fluxes were set on the surface, the upper mixed layer appears. The depth of the halocline does not change and is at about 20 m. Also in all experiments the relation between the southward and northward currents are close. Water exchange through the southward current is almost two times greater than that through the northward.
3D simulation of single bubble dynamics in a microchannel with a complex cross-sectional shape
Authors: Solnyshkina O A , Pityuk Yu A , Bulatova A Z 
Published: December 2020

Abstract
The relevance of a study of bubbly liquid dynamics in porous media is due to a wide range of their use in technological and industrial processes. This work is dedicated to the numerical study of the dynamics of single incompressible bubbles in a viscous fluid flow in a microchannel with a cross-section in the shape of a deltoid. This geometry is due to the similarity with the domain between closely packed cylindrical fibers, forming a porous medium, for example, in the manufacturing of composite materials. In the present study for solving the considered problems, the boundary element method (BEM) was chosen as a basis of the numerical approach, since all calculations were associated only with boundaries. BEM is effective in studying 3D problems in the domains with complex geometry and modelling objects with arbitrary deformation. The influence of the initial radius of the bubble, its position relative to the channel centerline on the bubble deformation, relative velocity of the mass center of the bubble to the average flow velocity in the channel is considered.
Distribution of wall shear stress for a bubbly flow in rod assembly
Authors: Vorobyev M A , Kashinsky O N 
Published: December 2020

Abstract
The work is devoted to the experimental study of the wall shear stress in the vertical assembly of rods in a square arrangement for a bubble flow. The measurements were carried out using the electrodiffusion technique. The data obtained during the experiment show that the void fraction has a significant effect on the flow structure near the walls of the rods. The change in wall shear stress with distance from the spacer grid does not occur monotonously, in contrast to the single-phase case.
The main flow parameters characterising the liquid film suction process on the blade surface in a steam turbine
Authors: Gribin V G , Tishchenko V A , Popov V V , Tishchenko A A , Gavrilov I Yu , Alekseev R A 
Published: December 2020

Abstract
In this study, the process of liquid film suction from surfaces of steam blades is considered. The main goal of the investigation is to provide the list of nondimensional parameters characterizing this phenomenon. The complex nature of this process requires the consideration of various flow features occurring with the film. The influence of slot geometry, flow conditions and suction regimes are studied. As a result, the processes of film separation, transient breakup and interphase interaction are considered. Based on the obtained information, the set of nondimensional parameters is formulated. Their accounting will allow conducting correct research in laboratory conditions to transfer its results to a real turbine. The numerical modelling is performed to verify the findings, and the regime for the experimental rig providing the same non-dimensional parameters as for real turbine is selected.
Investigation of the cooling of a high-temperature surface by a dispersed coolant flow
Authors: Smorchkova Yu V , Ilyin V V , Shteling V S , Zakharenkov A V , Komov A T , Sherbakov P P 
Published: December 2020

Abstract
A modernized experimental setup diagram is presented for studying the cooling of a high-temperature surface with a dispersed coolant flow. The results of an experimental study of unsteady heat removal from a target with a temperature exceeding the Leidenfrost temperature are presented. The cooling curves are obtained, the regions of effective heat transfer are determined. The primary experimental data were obtained during stationary heat transfer in the following range of operating parameters of the coolant: mass water flow rate 0.0038 ÷ 0.0145 kg/s; water pressure 0.4 ÷ 0.2 MPa, induction heating power 7 ÷ 20 kW.
The calculating model of microstructured flat plate wettability during evaporation into the stagnation flow
Authors: Makarov M S , Makarova S N , Syuzaev A I 
Published: December 2020

Abstract
The results of the analysis of the problem of wetting the microstructured flat wall surface during adiabatic liquid evaporation into a boundary layer of air flowing at right angles are presented. The basic conservation laws are formulated in the form of differential equations that allow calculating the velocity and height of liquid rise in capillaries, wetting dynamics, depth and mass of the liquid in capillaries, and the evaporation surface area.
On steam bubble patterns in superheated liquids
Authors: Vladyko I V , Pil’nik A A , Chernov A A 
Published: December 2020

Abstract
This paper presents the results of numerical simulation of steam bubble growth in a uniformly superheated liquid. The numerical calculation scheme takes into account both inertial and thermal effects. The main regularities of the prosses are discussed by the example of different superheat levels and different liquids: water, mercury and glycerin. Simple estimations of characteristic times of the inertial and transition stages are offered.
The effect of boron, copper, and magnesium on the ignition of HEM containing aluminum powder
Authors: Sorokin I V , Korotkikh A G , Selikhova E A 
Published: December 2020

Abstract
The use of metal powder as fuel in high-energy materials (HEM) for propulsion is the most energy-efficient method to increase the burning rate, combustion temperature, and specific impulse. Typically, various dispersity aluminum powders are used in the HEM composition. To improve the ignition and combustion characteristics of the HEM composition it is advisable to use the catalysts (nonmetals, metals or their oxides). This paper presents the experimental data of the HEM samples ignition containing ammonium perchlorate, butadiene rubber, micron powders of aluminum, aluminum-magnesium alloy, as well as nanopowders of amorphous boron, aluminum-copper, and aluminum-boron mixtures. The use of aluminum-copper or aluminum-boron nanopowders in the HEM composition decreases the ignition delay time by 1.3–2.0 times in comparison with Al-based HEM during CO2 laser initiation. In the case of Al-Mg powder use, the ignition delay time is changed slightly.
Numerical simulation of melting of scattering ice in a single-phase Stephan problem
Authors: Savvinova N A , Sleptsov S D , Grishin M A 
Published: December 2020

Abstract
A numerical study of the formation of the temperature field and the melting rate of an ice layer scattering radiation, located on an opaque substrate during radiation heating was carried out. To solve the radiation part of the problem, a modified mean fluxes method was used, taking into account the volume absorption and scattering of radiation into the medium, as well as the selective nature of the radiation source. The effect of the spectral volumetric properties of ice on the melting and temperature increase of the non-irradiated side is shown. Comparison of calculation results with experimental data shows satisfactory agreement.
Error estimation of the multi-angle phase triangulation method for measuring the three-dimensional geometry of convex and extended objects
Authors: Dvoynishnikov S V , Chubov A S , Pavlov V A , Bakakin G V 
Published: December 2020

Abstract
The work describes the estimation of the error of the multi-angle phase triangulation method for measuring the three-dimensional geometry of convex and extended objects. Theoretical estimates of the measurement error are made and the results of mathematical modeling are presented. It is shown that if the measurement error by the phase triangulation method has normal distribution, the results of stitching a three-dimensional surface will also have a normal distribution with similar characteristics.The multi-angle phase triangulation method for measuring the three-dimensional geometry of convex and extended objects provides the necessary level of measurement accuracy and can be used to obtain the three-dimensional geometry of complex-shaped convex and extended objects in industrial conditions.
Approbation of the Laser Doppler Anemometer Lad-08 on the Secondary Standard Test Rig for Air Flow Speed
Authors: Kabardin I K , Meledin V G , Dvoinishnikov S V , Pavlov V A , Bakakin G V , Samoilenko A I , Inshakov S I 
Published: December 2020

Abstract
In the field of fundamental metrology and ensuring the unity of measuring instruments, the role of optical information methods, systems and technologies of non-contact diagnostics of dynamic processes is extremely relevant. The profiles of the axial velocity component were measured in the working section of the secondary standard test rig for air flow speed. The flow kinematics inside the working section is studied using a laser Doppler anemometer (LDA) with an adaptive temporal selection of the velocity vector (LAD-08).