bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs
Authors: Pavarotti Greta S. , Hivernaud Vincent , Brincin Mélanie , Roche Régis , Barreau Pierre , Festy Franck , Gauthier Olivier 
Published: April 2020

Abstract
Objective The aim of this study was to investigate the safety, feasibility and clinical efficacy of a single intra-articular injection of autologous and purified micro-fragmented adipose tissue for the treatment of osteoarthritis (OA) in dogs.
Study Design Twenty-one client-owned dogs with radiographically confirmed OA were recruited into this prospective study. Lameness and discomfort were evaluated by physical examination at day 0 and then 14, 30, 60 and 180 days after injection. Kinetic data and temporospatial parameters were obtained using a pressure-sensing walkway. Peak vertical force, vertical impulse and percentages of body weight distribution were determined. Owner perception data regarding their own dog's physical activity were also collected using the Canine Brief Pain Inventory.
Results Radiographic scores for OA from days 0 to 180 were similar, except in two dogs. No major side effects were noted after injection. Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post-injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%). In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0.
Conclusion Regenerative autologous adipose tissue injection therapy is a promising alternative to traditional analgesics treatment in patients with OA, associated with significant reductions in pain and lameness, delayed disease progression and improved quality of life.
Oral Hygiene Awareness on Patients Attending Dental OPD in A.B. Shetty Memorial Institute of Dental Sciences
Authors: Asok Anjhana , Bhandary Rahul , Shetty Mamatha , Shetty Smitha , Ramesh Amitha 
Published: April 2020

Abstract
Background- Oral hygiene is highly personalised concept and major public health concern that relies on an individual's culture and socio-economic status. Hence, it is imperative that health services should be made available to all rural/semi urban areas as well. Thus it is important to create awareness through various public health programs regarding oral hygiene and its effects on general health in order to change the total perspective of the patients towards dental problems to lead a healthy quality life.
Objective- Thus the aim of this study is to assess the oral hygiene awareness and their knowledge on different oral hygiene practices.
Materials and Methods- A total of 369 patients participated in the study.. The patients were interviewed on questionnaire basis. A self-reported questionnaire consisting of 26 multiple choice questions written in English were given to the patients.
Statistical analysis- Descriptive statistics such as frequency and percentage was used to assess the oral health awareness and oral hygiene practice among the subjects who are attending A.B Shetty Memorial Institute Of Dental Sciences, Derlakatte, Mangalore.
Results- The result of this study showed an acute lack of oral hygiene awareness and limited knowledge of oral hygiene practices. Most of the patients were not aware of the relationship between systemic and general health.
Conclusion- Hence there is an urgent need to educate and motivate the patients for better oral hygiene awareness and practises and conduct various health programs for the same.
Oxidative Stress Marker and Fibrinogen Level as Indicators of Severity of Diabetic Foot Ulcer
Authors: Oo Aung Myo , Lwin Ohn Mar , Kanneppady Sowmya Sham , Kanneppady Sham Kishor 
Published: April 2020

AbstractDiabetic foot ulcer (DFU) is the leading cause of lower extremity amputation and is very common in clinical practice. Oxidative stress is important in the pathogenesis of chronic wound and the lipid per oxidation product malondialdehyde (MDA) is toxic molecule which is also associated with pathogenesis of chronic complications of diabetes mellitus. Fibrinogen is a recognized marker in peripheral arterial disease (PAD) and increasing level predict an increased risk of amputation. The aim of this study was to investigate whether the plasma MDA and fibrinogen are associated with severity of DFU. In this study, the plasma MDA and fibrinogen levels were determined in 23 normal subjects, 25 diabetes without ulcer patients, 24 mild DFU patients and 25 severe DFU patients. The results showed that mean plasma MDA levels of normal subjects, diabetes without foot ulcer patients, mild DFU patients and severe DFU patients were 0.98± 0.12 μmol/L, 1.3±0.21 μmol/L, 1.61±0.22 μmol/L and 2.3±0.35 μmol/L respectively. Mean plasma fibrinogen levels of normal subjects, diabetes without foot ulcer patients, mild DFU patients and severe DFU patients were 307± 61.5 mg/dl, 429±63.8 mg/dl, 513.6±77.8 mg/dl and 643.5±71.3 mg/dl respectively. We found out that mean plasma MDA level of severe DFU patients was significantly higher than that of other groups (p<0.001). Similarly, mean plasma fibrinogen level of severe DFU patients was significantly higher than that of normal subjects, diabetic without ulcer patients and mild DFU patients (p<0.001). Therefore, we concluded that the higher level of plasma MDA and fibrinogen are significantly associated with severity of DFU.
Executive Functioning in Healthy Aged Population in comparison to Young Adults Using Cognitive Estimation Test
Authors: S. Shrunga M , Sengolraj Livingston , B. Radish Kumar 
Published: April 2020

Abstract
Background and objective: Cognitive estimation is an important task in which people engage themselves in estimating the environment in different aspects of their life, such as; distance, quantity, size, weight etc The study was taken up to evaluate the cognitive estimation skills in Healthy Aged Population in comparison to Young Adults.
Methodology: A total of 40 healthy young and old adults participated in the study. The participants were divided into two groups. Cognitive Estimation Test (CET) was administered for both the groups. The CET, was modified to suit Indian population consisted of 18 questions under the domains of distance, quantity, size, weight, temperature and time. Responses were scored for Under-estimation (UE), Over-estimation (OE), Approximate answer (AA), and No answer (NA). Number of UE, OE, AA, and NA were calculated. Independent t-test was employed to find out the significant differences between the means of both the groups.
Results: Results revealed that young adults were better in estimating the environment when compared to healthy aged population, which was significant .Distance and size dimensions were remarkably affected in comparison to all other dimensions. Instances of No answers (NA) were higher in healthy aged population in comparison to young adults.
Conclusion: The results indicate that, the decline in cognitive estimation abilities is a part of healthy aging rather than a pathological condition. Thus CET can be used as a tool in the assessment and management of cognitive disorders.
Urinary tract infections by multidrug resistant Acinetobacter species- A Retrospective Analysis
Authors: Mule Prashant , Patil Niranjan , Gaikwad Seema 
Published: April 2020

Abstract
Background: Acinetobacter species have emerged as important cause of nosocomial infections like pneumonia and urinary tract infections. Acinetobacter species are known to be highly resistant to commonly used antimicrobial agents. SinceAcinetobacter species are ubiquitous and have tremendous colonizing capacity, it is difficult to explain the role of Acinetobacter acquisition in the ICU and medical wards. The objective of this study was to determine the frequency of urinary tract infection (UTI) caused by different Acinetobacter species in hospitalized patients and in the community and to analyze their antimicrobial susceptibility pattern.
Materials and Methods: This is a retrospective analysisfrom January 2016 to December 2017. Urine samples collected in appropriate sterile manner were screened for polymorphonuclear leucocytes and bacteria by routine microscopic examination. This was followed by plating on MacConkey's agar and Blood agar. Isolated Acinetobacter strains which are oxidase negative and non-lactose fermenters from MacConkey's agar were identified with Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) to confirm the TM identification. Antibiotic susceptibility was performed by VitekCompact™ 2 (Biomeuriux, France) as per CLSI standards establishing MIC (Minimum Inhibitory Concentration).
Results: Of the 429 isolates of Acinetobacterspecies from urinary tract, Acinetobacterbaumannii complex (78%) found to be the most common species followed by Acinetobacterjunii(10%) and Acinetobacterbaumannii(8%). Of the 334 (78%) isolates of Acinetobacterbaumannii complex from urinary tract, 73 (21.85%) isolates were resistant with doripenem, 62 (18.56%) with imipenem and 59 (17.66%) were resistant with meropenem with MIC values >=8 μg/ml. The rest of the isolates like Acinetobacterjunii, Acinetobacterjohnsonii, andAcinetobacterlwoffiiare found to be more sensitive with carbapenems with lower MIC values.
Discussion: The treatment of multidrug-resistant bacteria in hospitalized patients continues to be a challenge for the clinician's in routine practice. Acinetobacter baumannii complex has proven to be an important pathogen in health care associated infections with significant mortality and morbidity. The drug resistant nature of the pathogen and its unpredictable susceptibility patterns make empirical and therapeutic decisions even more difficult.
Conclusion: A. baumanniiis an important opportunistic agent of nosocomial UTI, especially in patients with longer hospitalization, antibiotic exposure, urinary catheterization and decreased immunity. High antimicrobial resistance and patient co-morbidities limit therapeutic choices. Hence, alternative therapeutic options are urgently needed to treat a patient with A. baumanniiinfection.
A Case Report of Meilodosis
Authors: Bhandary Satheesh Kumar , Mani Ivan Paraekulam , Aroor Rajeshwary , Bhat Vadisha 
Published: April 2020

AbstractMeilodosis is an infection caused by a gram negative bacterium, Burkholderia pseudomallei associated with high fatality rates. This organism is a widely distributed environmental saprophyte found in soil and stagnant water in the endemic regions of south East Asia and 1 Australia. It was first diagnosed in Burma by Captain Alfred Whitmore, and his assistant, C.S. 2 Krishnaswami in 1911. Meilodosis is an emerging pathogen in South India predominantly due to negligent management and a delayed diagnosis.The majority of the cases of B. pseudomallei infections are subclinicalwith the primary modality of transmission being through broken skin. The disease predominantly manifests in individuals 3 with diabetes mellitus, chronic renal disease and alcoholism. The majority of patients present 4 with pyrexia and localized skin ulcerations or abscesses. There is a high incidence of 5 pneumonia and septic shock following contamination. Transmission from a patient by droplet 6 spread is rare even with the presence of pulmonary melioidosis. Meliodosis of the head and neck region is not common, however it accounts for 40% of the cases of supportive parotitis in 7 children in Thailand and Cambodia. Diagnosis can be challenging due to its close symptomatic resemblance to tuberculosis. Isolation of the organism is difficult; this leads to poor identification of the causative agent and mismanagement.
Management of Congenital Muscular Torticollis (Cmt) with a Multidisciplinary Approach
Authors: Gattani Anurag , Bhat Vinaya , Hegde Chethan , Shetty Manoj , Hegde Padmaraj J. , Rai Ashish J. , Jaiswal Raj 
Published: April 2020

AbstractCongenital Muscular Torticollis (CMT) is a rare condition which is seen in childhood where there is difficulty in rotating the neck and the head is tilted to one side following the stiffness of the sternocleidomastoid muscle. When the patient reports for treatment during adulthood, a multidisciplinary approach involving surgical, prosthodontic and physiotherapy procedures are required. In this case report, the authors are describing successful management of an adult patient affected with CMT.
A Study On Health-Related Quality of Life Among The Stroke Patients In A Tertiary Care Hospital, Mangalore
Authors: Nesan G Shiny Chrism Queen , Kundapur Rashmi 
Published: April 2020

Abstract
Introduction : Stroke is a leading cause of death and acquired human disability in India. One dimension that is rarely measured, is health-related quality of life (HRQOL) which aims to assess the impact of disease from the perspective of the patient.
Objectives : To study the health-related quality of life among stroke patients within 3 months of stroke.
Materials & Methods : A hospital based study conducted on 20 stroke patients from the registry. The patients with fresh stroke attack and those who were attending the follow up within the first 3 months of the attack were enrolled in the study. Basic demographic data and the data of stroke outcomes were taken. HRQOL was evaluated using the Indian version of the Medical Outcomes Study 36 item Short-Form Health Survey (SF-36). Frequency and percentages were calculated.
Results: It was seen that majority (55%) of patients expressed a fair physical domain post stroke. About 40% were of opinion that their physical domain was poor and the rest said that it was good (5%). Assessing the psychological domain, majority of the patients said it was poor. Of the 20 patients, 15 (75%) of them were scaled to have poor social domain and the rest (25%) said it was fair. About half (50%) of the patients showed that they had poor environmental domain. About 15% of them said that it was good. Majority (60%) of the patients had poor general health status.
Emergency Services Received By the Patients with the Standard Protocol of Emergency Room
Authors: Sequera Sonia Karen Liz , Cutinho Savitha Pramilda , Quadros Adriel Benita , Binny Stephy , Siangshai Wandashisha 
Published: April 2020

AbstractEmergency Services are life saving measures for critically ill patients. If critically ill patients are not treated on time, the morbidity rates are likely to increase day by day. Hence, appropriate emergency care should be provided in each Emergency Department of the hospitals. This study intends to assess the Emergency Services provided to the patients in the Emergency Room of a hospital and also assess the level of patient satisfaction regarding the Services received.
Aims : To identify the services received by the patients in the emergency room and to find out the patient satisfaction regarding the services received and to associate satisfaction level of emergency services with selected demographic variables.
Settings and Design : Emergency department of a selected medical college hospital, Mangaluru and a Cross sectional descriptive study design.
Material and Methods : A protocol based checklist of Emergency Services and a Semantic Differentiation scale to assess the satisfaction level of emergency services.
Statistical analysis used : Frequency, Percentage, Mean, Standard Deviation and Chi-Square for association.
Results : The major findings of the study shows that out of 60 patients 55% rated the services available as very good, 43% as good & 2% as satisfactory and with regard to satisfaction level, 90% patients were satisfied regarding the Emergency Services received in an Emergency Room.
Conclusions : Pooled results showed that majority of the patients were satisfied with the emergency Services received and rated the available services as very good. Hence it reveals that the health care professionals of the selected hospital followed the emergency protocol of the hospital.
An Unusual Presentation of Glucose Transporter Type 1 Deficiency Syndrome
Authors: G. Saritha , S. Bhavani 
Published: April 2020

AbstractGlucose serves as the major energy sources for developing brain. In the resting state, the adult brain can consume up to 25% of the body's total glucose supply, while in infants and children it can use as much as 80%. Glucose entry into brain occurs via glucose transporter proteins GLUTs). They are five GLUTs protein. Out of five GLUTs 1 and GLUTS 3 are located in brain, with GLUTs-1 found in blood brain barrier and choroid plexus and GLUTs-3 found in neurons. Glucose transporter type 1 deficiency syndrome is an impaired glucose transport into the brain as the result of a mutation of the SLC2A1 gene leads to development of a metabolic encephalopathy of developing brain.
Comparative Evaluation of Pre-Donation Haemoglobin Screening Methods
Authors: Rao Chandrika , S. Sanjana D. 
Published: April 2020

AbstractBackground:The pre-donation haemoglobin (Hb) estimation is the only laboratory test done on blood donors to determine an individual's eligibility to donate blood with an intention to prevent bleeding an anaemic donor. With availability of wide range of screening methods, no single technique has emerged as the most appropriate and ideal for screening blood donors. The primary objective of the study was to compare results of copper sulphate method and haemoglobin meter with the gold standard Cyanmeth hemoglobin (CyanHb) method.
Materials and methods : Prospective observational study done in 238 blood donors. Sample analyses were done using Copper sulphate solution, haemoglobin meter and Cyanmeth haemoglobin method.
Results : Mean values of three methods Cyanmeth haemoglobin, and Haemoglobin meter methods are 12.5±2.2, and 13.08±1.61 respectively. Haemoglobin values obtained by haemoglobin meter and copper sulphate methods were comparable, with sensitivity of 94.25% and 94.47% respectively.
Conclusion : CuSo4 method and haemoglobin meter can be used alternatively based on resources available. The higher values obtained by CyanHb method could be due to turbidity factor of the lipids in the blood sample.
Quantum state estimation with nuisance parameters
Authors: Suzuki Jun , Yang Yuxiang , Hayashi Masahito 
Published: April 2020

Abstract
In parameter estimation, nuisance parameters refer to parameters that are not of interest but nevertheless affect the precision of estimating other parameters of interest. For instance, the strength of noises in a probe can be regarded as a nuisance parameter. Despite its long history in classical statistics, the nuisance parameter problem in quantum estimation remains largely unexplored. The goal of this article is to provide a systematic review of quantum estimation in the presence of nuisance parameters, and to supply those who work in quantum tomography and quantum metrology with tools to tackle relevant problems. After an introduction to the nuisance parameter and quantum estimation theory, we explicitly formulate the problem of quantum state estimation with nuisance parameters. We extend quantum Cramér–Rao bounds to the nuisance parameter case and provide a parameter orthogonalization tool to separate the nuisance parameters from the parameters of interest. In particular, we put more focus on the case of one-parameter estimation in the presence of nuisance parameters, as it is most frequently encountered in practice.
Invited Commentary: The Epidemiology of Electronic Cigarettes and Reproductive Health Begins
Authors: Savitz David A 
Published: April 2020

AbstractHarlow et al. (Am J Epidemiol. 2021;190(3):353–361) are among the first to tackle the complex subject of electronic cigarette use and reproductive health, focused on fecundity but pertinent to the full spectrum of reproductive health concerns. Despite extensive documentation of the health harm from tobacco use and a shared exposure to nicotine, electronic cigarette (e-cigarette) users have a markedly different exposure profile. Because e-cigarettes might help to curtail or eliminate tobacco smoking, the health comparisons of interest for e-cigarettes should include cigarette smoking as well as no use of such products. These researchers confront significant methodological challenges in the study of reproductive health effects of e-cigarettes: addressing confounding with little information on the characteristics of e-cigarette users, a complex connection between e-cigarette and tobacco use, multiple and poorly understood exposure to e-cigarette vapors, and lack of a standard method for quantifying exposure. Evidence is urgently needed to inform regulation and individual decisions regarding the use of this potentially harmful product that might well entice new users of nicotine, some of whom progress to tobacco use, but that also has the potential to enable otherwise recalcitrant smokers to substitute a less harmful product.
Prevalence of Angiotensin II Type 1 Receptor Antibodies in Persons With Hypertension and Relation to Blood Pressure and Medication
Authors: Philogene Mary Carmelle , Han Dingfen , Alvarado Flor , Fedarko Neal S , Zonderman Alan B , Evans Michele K , Crews Deidra C 
Published: April 2020

Abstract

BACKGROUND
We aimed to determine the prevalence of antibodies against angiotensin II type 1 receptor (AT1RAb) in hypertensive adults and elucidate the relation of antihypertensive medication type to blood pressure (BP) among persons with and without AT1RAb.

METHODS
Sera from participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with hypertension were tested for AT1RAb using a commercial Enzyme-linked immunosorbent assay (ELISA) (One Lambda; positive ≥17 units/ml). BP measurements, uncontrolled BP (systolic BP ≥140 and/or diastolic BP ≥90 mm Hg), and effect of BP medication type were compared for AT1RAb positive (+) vs. negative (−) participants using descriptive statistics and multivariable regression.

RESULTS
One hundred and thirty-two (13.1%) participants were AT1RAb+. Compared with AT1RAb−, AT1RAb+ persons were more likely to be white (47% vs. 36.7%; P = 0.03) but had similar comorbid disease burden. In models adjusting for age, sex, and race, AT1RAb+ persons had higher diastolic BP (β = 2.61 mm Hg; SE = 1.03; P = 0.01) compared with AT1RAb− participants. Rates of uncontrolled BP were similar between the groups. AT1RAb+ persons on an angiotensin receptor blocker (ARB; n = 21) had a mean of 10.5 mm Hg higher systolic BP (SE = 4.56; P = 0.02) compared with AT1RAb+ persons using other BP medications. The odds of uncontrolled BP among AT1RAb+ participants on an ARB was 2.05 times that of those on other medications. AT1RAb− persons prescribed an angiotensin-converting enzyme inhibitor (ACEi) had 1.8 mm Hg lower diastolic BP (SE = 0.81; P = 0.03) than AT1RAb− persons not prescribed an ACEi.

CONCLUSIONS
AT1RAb was prevalent among hypertensive adults and was associated with higher BP among persons on an ARB.