bluuebunny/crossref_metadata_2025_split huggingface dataset:
AUTOVACCINATION: EFFECTIVE PERSONIFIED TREATMENT OF CHRONIC INFECTIONS (WHEN ANTIBIOTIC THERAPY IS POWERLESS)
Authors: Minuchin Valery , Gareev Oleksii , Sklyar Nadiia , Kravets Tetiana 
Published: February 2020

In this article we review and discuss data of the use and mechanisms of action of autovaccines. The idea of autovaccination is that killed microorganisms could be used not only in prevention, but also in the treatment of infections. Autovaccines are prepared individually from strains of microorganisms isolated from the patient. The pathogens are inactivated and then administered in increasing concentrations. Autogenous vaccines permit treatment of infections caused by bacteria against which no preventive vaccine has been available.
Autovaccine therapy has a long history, it have been used since the beginning of the 20th century to treat chronic infections. From the literature is known, that autovaccines have been used for treatment diseases’ of the skin, bones, joints, digestive organs, genitals, periodontal, eye, ears, nose and respiratory system the history of the half-century use of auto vaccines has shown that they may be a promising alternative in the treatment of chronic infections.
However from the middle of the 20th century autovaccines have been forgotten because of efficient antibiotic therapies. But now rapid spread of multiresistant bacterial and fungal strains enforces the development of new strategies to combat chronic infections. In view of the variability of the bacterial species, personalized approaches could hold promise for patients with recurrent or chronic infection. Therefore interest to autovaccines returns.
Autovaccines have been used to treat ongoing chronic infection but their mechanism of action is still unknown. Recently, the results of several studies have been published that examined the effects of autovaccines on the immune system. But published data are quite inconsistent and incomplete. Therefore further research is required in this area.
So clinical studies from the early 1900s and novel autovaccination approaches suggest an alternative strategy to antibiotic therapy.
STAN IMMUNITETU AND CORRECT REMEDIES IN BORIES ON SEASONAL ALERGIC RINIT ON ONLY DESTRUCTED INTESTINAL MICROBIOCENOSIS THAT KARCHATOUS STATUS
Authors: Bondarenko Tatyana , Litus Viktor , Kuznetsov Alexey , Kuznetsova Larisa , Nazar Oleg 
Published: February 2020

Introduction. Nutrition is one of the most significant environmental factors that affects the functional state of all organs and systems, determines the state of adaptive capabilities of the body, promotes health, or vice versa, causes the development of diseases, contributes to their chronicity and progress. The functional state of organs and systems by a patient with seasonal allergic rhinitis (ATS) is determined by the reserves of energy, plastic and regulatory support that cells receive with food. Inadequate nutrition is also one of the causes of secondary immunodeficiency, which has a negative effect on the course of ATS.
Materials and methods. We studied 75 patients with ATS with mild and moderate disorders of the pathological process and taking into account disturbances in intercellular cooperation, an increase in IL-4, specific IgE and TNF-α against the background of a nutritional disorder occurring with mild immunological indicators of systemic immunity.
Research results. Three groups of patients were distinguished: 1 group of 25 patients with a lack of body weight; Group 2 – 25 patients whose body weight was within normal limits; Group 3 – 25 overweight patients and Group 4 (control) comparisons (healthy people) – 25 people.
Discussion of research. The data obtained indicate the effectiveness of the developed therapy, which includes dietary correction and a comprehensive differentiated approach in the appointment of pre- and probiotics. The effectiveness of treatment is indicated by the positive dynamics of the clinical manifestations of intestinal dysbiosis.
Conclusions. In addition to positive changes in intestinal symptoms, in patients with ATS, there was a positive dynamics in the gastrointestinal tract, as well as normalization of specific and non-specific indicators of immunity. The effectiveness of the specific treatment of patients with ATS against intestinal dysbiosis is increased by 85%.
RELATION OF Th1, Th2, Treg, Th17 CYTOKINES OF PERITONEAL FLUID IN WOMEN WITH ENDOMETRIOSIS, ASSOCIATED WITH INFERTILITY
Authors: Koval H.D. , Yuzko O.M. , Kurchenko A.I. 
Published: February 2020

Endometriosis is one of the leading diseases of the female reproductive organs and is the cause of almost a third of all cases of female infertility. It has been suggested that in women with endometriosis associated with infertility, the levels, nature of production and the ratio of cytokines of cells of different profiles in the peritoneal fluid change, which may play a pathogenetic role (to promote the development of immune inflammation of a certain type) in the development of the disease itself infertility.
Aim of the study: to determine the features of the ratio of Th1, Th2, Treg, Th17 cytokines of peritoneal fluid in women with endometriosis associated with infertility.
Materials and methods: The study group included 58 women who were diagnosed with external genital endometriosis, namely: peritoneal form and infertility for at least 2 years. The control group consisted of 30 women with tubal genital infertility. No other pathological process, at the time of observation, was detected in control patients. The study was conducted at the Center for Infertility Treatment (Chernivtsi) from 2009 to 2015, following the concept of informed consent of the patient to conduct research and other ethical principles in relation to persons who are the object of the study. Peritoneal fluid was collected during laparoscopy during the proliferative phase of the menstrual cycle. Cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA).
The results of the study. The cytokine profile in the peritoneal fluid of women with infertility-associated endometriosis is characterized by an increase in levels of IL-2, TNF-α, IL-6, IL-17, IL-10, IL-18. The largest proportion of all cytokines under study in the peritoneal fluid is IL-10 (28%), followed by IL-2, IL-6 and IL-18 in the order of decreasing relative amount (16%, 14% and 13%, respectively). respectively. The TGF-β (7%) was then placed in relative weight reduction. TNF-α and IL-17 6% each; IL-12 (4%); IL-1β and INF-γ are 3% percent each. The lowest proportion, as in the peripheral blood, was IL-4, which was incomplete 1 percent. The total relative number of cytokines Th1 is 25%, cytokines Th2 – incomplete 15%, cytokines Treg cells – 35%, cytokines Th 17 – IL-17 is 6% and cytokines produced mainly by macrophages and killer cells – 20%. Thus, the total ratio of Th1/Th2 cytokines in women with endometriosis was 2.5:1.5.
Conclusions: In the peritoneal fluid, pronounced changes in the cytokine profile are observed, significantly prevail over changes in the peripheral blood, and are characterized by the growth of IL-2 (p <0.001), TNF-α (p <0.001), INF-γ (p <0.001), IL -6 (p <0.001), IL-17 (p <0.001), IL-10 (p <0.001), TGF-β (p <0.05), IL-12 (p <0.001), IL-18 (p <0.001). Local production is characterized by a 2.45-fold decrease in the Th1/Th2 cytokine ratio, which indicates a predominance of the Th2-mediated immune response.
11. Anatomía de un Sistema de Información Geográfica (SIG) para el patrimonio arqueológico del centro de la provincia de Buenos Aires.
Authors: Mariano Carolina I. , Endere María Luz , Pedrotta Victoria , Mariano Mercedes 
Published: February 2020

La gestión del patrimonio arqueológico en la provincia de Buenos Aires, Argentina, ha sido poco abordada en trabajos científicos pese a las numerosas investigaciones realizadas en la región durante las últimas décadas. Una de las posibles causas de la falta de políticas efectivas de protección puede deberse, entre otros factores, a la carencia de las herramientas metodológicas adecuadas. El objetivo de este trabajo es presentar un conjunto de estrategias que apuntan a resolver este problema. Las mismas se basan en el desarrollo de una metodología para la gestión de la información arqueológica de tres partidos del centro de la provincia de Buenos Aires: Tandil, Olavarría y Azul, instrumentada por medio de un Sistema de Información Geográfica que, a su vez, es susceptible de ser adaptado a cualquier otra área de interés. Se presenta la estructura interna de dicho sistema, se describe cada una de las variables de la herramienta generada y se plantea, además, la necesidad de un trabajo interdisciplinario para la obtención y sistematización de los datos. Finalmente, se brindan los argumentos por los cuales esta herramienta constituye hoy un insumo clave e innovador para la planificación de políticas de gestión patrimonial a nivel provincial.
Marcadores de etnicidad y agencia en las pautas alimenticias. Su abordaje desde la Zooarqueología Histórica
Authors: Colasurdo María Belén 
Published: February 2020

A partir del análisis de los restos óseos de fauna en sitios históricos se pueden indagar diferentes temas de investigación relacionadas con la alimentación, como etnicidad, interacción entre poblaciones nativas e inmigrantes y agencia. El objetivo de este trabajo es presentar las inferencias realizadas en cuatro sitios arqueológicos de la ciudad de Rosario, correspondientes a los siglos XVIII y XIX: Casa Parroquial, Juan Manuel de Rosas, La Basurita y Arenales. La particularidad de los mismos radica en que corresponden cronológicamente con la masiva llegada de inmigrantes hacia mediados del siglo XIX y el consiguiente crecimiento de la ciudad con el pasaje de los siglos. La hipótesis es que estos cambios se reflejaron en el registro arqueológico, tanto en las especies preferidas para el consumo como en las formas de prepararlos. Si bien la evidencia no es concluyente, ya que se deben atender a otros factores, algunas inferencias como la mayor presencia de consumo de ovejas por sobre el de vacas para el final del período, la diversificación de los tipos de platos preparados, nos hablan de la interacción entre pobladores de distintos orígenes que puede haber permitido una síntesis de pautas alimentarias.
Restos arqueobotánicos del sitio arqueológico Fuerte Sancti Spiritus, Santa Fe, Argentina.
Authors: Colobig M. de los Milagros , Zucol Alejandro , Brea Mariana , Franco M. Jimena , Passeggi Esteban , Cocco Gabriel , Sánchez-Pinto Ibán 
Published: February 2020

El asentamiento español de Sancti Spiritus se estableció en algún momento indeterminado entre mayo y agosto de 1527 en la confluencia de los ríos Carcarañá y Coronda, cuando arribó una expedición al mando de Sebastián Caboto. Este sitio arqueológico marca el inicio de la presencia europea en la región y con ello la introducción de nuevas especies vegetales. Los resultados obtenidos a partir del análisis de los fitolitos y los carbones arqueológicos del sitio contribuyen con información novedosa debido a que en ambos casos se identificaron vegetales introducidos en un contexto hispano-indígena de principios del siglo XVI. Los carbones debieron ser introducidos por los colonizadores, dado que fueron asignados a gimnospermas afines a pino silvestre (Pinus sylvestris) y tejo (Taxus baccata). La presencia de gimnospermas en un sitio arqueológico argentino representa la evidencia material más antigua de maderas de origen exótico en momentos históricos. Las asociaciones fitolíticas identificadas responden a vegetales afines a gramíneas locales (Maideae y Oryzoideae) y un tipo de vegetal introducido, como es el caso de las formas afines a trigo (Triticeae). Los análisis arqueobotánicos aportan información que sumada a los registros históricos, proporcionan elementos para la reconstrucción de este acontecimiento relevante para la historia hispanoamericana.
Internal Structure and CO2 Reservoirs of Habitable Water Worlds
Authors: Marounina Nadejda , Rogers Leslie A. 
Published: February 2020

Abstract
Water worlds are water-rich (>1 wt% H2O) exoplanets. The classical models of water worlds considered layered structures determined by the phase boundaries of pure water. However, water worlds are likely to possess comet-like compositions, with between ∼3 and 30 mol% CO2 relative to water. In this study, we build an interior structure model of habitable (i.e., surface liquid ocean–bearing) water worlds using the latest results from experimental data on the CO2–H2O system to explore the CO2 budget and localize the main CO2 reservoirs inside of these planets. We show that CO2 dissolved in the ocean and trapped inside of a clathrate layer cannot accommodate a cometary amount of CO2 if the planet accretes more than 11 wt% of volatiles (CO2 + H2O) during its formation. If the atmosphere holds more than a negligible amount of the CO2 (>0.01% of the planet mass), the planet will not have a habitable surface temperature. We propose a new, potentially dominant, CO2 reservoir for water worlds: CO2 buried inside of the high-pressure water ice mantle as CO2 ices or (H2CO3 · H2O), the monohydrate of carbonic acid. If insufficient amounts of CO2 are sequestered in either this reservoir or the planet’s iron core, habitable-zone water worlds could generically be stalled in their cooling before liquid oceans have a chance to condense.
Interplanetary Coronal Mass Ejections as the Driver of Non-recurrent Forbush Decreases
Authors: Papaioannou Athanasios , Belov Anatoly , Abunina Maria , Eroshenko Eugenia , Abunin Artem , Anastasiadis Anastasios , Patsourakos Spiros , Mavromichalaki Helen 
Published: February 2020

Abstract
Interplanetary coronal mass ejections (ICMEs) are the counterparts of coronal mass ejections (CMEs) that extend in the interplanetary (IP) space and interact with the underlying solar wind (SW). ICMEs and their corresponding shocks can sweep out galactic cosmic rays (GCRs) and thus modulate their intensity, resulting in non-recurrent Forbush decreases (FDs). In this work, we selected all FDs that were associated with a sudden storm commencement (SSC) at Earth, and a solar driver (e.g., CME) was clearly identified as the ICME’s source. We introduce and employ the tH
parameter, which is the time delay (in hours) of the maximum strength of the interplanetary magnetic field from the FD onset (as is marked via the SSC), and consequently derive three groups of FD events (i.e., the early, medium, and late ones). For each of these we examine the mean characteristics of the FDs and the associated IP variations per group, as well as the resulting correlations. In addition, we demonstrate the outputs of a superposed epoch analysis, which led to an average time profile of the resulting FDs and the corresponding IP variations, per group. Finally, we interpret our results based on the theoretical expectations for the FD phenomenon. We find that both the shock sheath and the ejecta are necessary for deep GCR depressions and that the FD amplitude (A0) is larger for faster-propagating ICMEs. Additionally, we note the importance of the turbulent shock-sheath region across all groups. Finally, we present empirical relations connecting A0 to SW properties.
GW170817A as a Hierarchical Black Hole Merger
Authors: Gayathri V. , Bartos I. , Haiman Z. , Klimenko S. , Kocsis B. , Márka S. , Yang Y. 
Published: February 2020

Abstract
Despite the rapidly growing number of stellar-mass binary black hole mergers discovered through gravitational waves, the origin of these binaries is still not known. In galactic centers, black holes can be brought to each others’ proximity by dynamical processes, resulting in mergers. It is also possible that black holes formed in previous mergers encounter new black holes, resulting in so-called hierarchical mergers. Hierarchical events carry signatures such as higher-than-usual black hole mass and spin. Here we show that the recently reported gravitational-wave candidate, GW170817A, could be the result of such a hierarchical merger. In particular, its chirp mass ∼40 M
⊙ and effective spin of χ
eff ∼ 0.5 are the typically expected values from hierarchical mergers within the disks of active galactic nuclei. We find that the reconstructed parameters of GW170817A strongly favor a hierarchical merger origin over having been produced by an isolated binary origin (with an odds ratio of > 103).
Qu’est-ce qu’un Turc ? (Égypte, Syrie, xvie siècle)
Authors: Lellouch Benjamin 
Published: February 2020

L’article étudie les occurrences du mot « Turc » dans les sources arabes et turques, tout particulièrement les chroniques, écrites en Égypte et en Syrie ottomanes au xvie siècle. Il examine ce qu’elles définissent comme « turc » : les individus portant le nom « Le Turc », les réalités « turques » ou relevant des « Turcs », les qualités morales des « Turcs ». Puis il se penche sur les termes dont le contexte montre qu’ils désignent des groupes distincts des « Turcs », ou qu’au contraire ils se confondent avec ces derniers. Il en ressort que le « Turc » est un non-« Arabe », militaire ou plus généralement membre de la gent d’État (askeri), donc un Ottoman, même si « Turc » est beaucoup plus rare que « Roum ». Le mot a un accent élitaire, alors que comme on le sait, il désigne avant tout un rustre en Anatolie et dans les Balkans ; cette opposition n’est pas surprenante si l’on songe que déjà au Moyen-Âge les usages du terme étaient soit spécifiques, soit génériques, et les représentations des « Turcs » largement contradictoires. Des références comparatives à Alger et au Yémen laissent penser que la distinction d’avec les « Arabes » fut déterminante dans la construction de l’identité « turque » dans les provinces arabes de l’Empire ottoman.
RETRACTED - The biological mechanism involved in anticancer properties of amniotic membrane
Authors: Jafari Ameneh , Niknejad Hassan , Rezaei-Tavirani Mostafa , D’Amico Caitlin , Zali Hakimeh 
Published: February 2020

This paper has been retracted. See the Retraction note at: https://doi.org/10.4081/oncol.2020.493
Applying Linguistics in Illness and Healthcare Contexts
Authors: Demjén Zsófia 
Published: February 2020

All aspects of illness and healthcare are mediated by language: experiences of illness, death and healthcare provision are talked and written about (face-to-face or online), while medical consultations, research interviews, public health communications and even some diagnostic instruments are all inherently linguistic in nature. How we talk to, about and for each other in such a sensitive context has consequences for our relationships, our sense of self, how we understand and reason about our health, as well as for the quality care we receive. Yet, linguistic analysis has been conspicuously absent from the mainstream of medical education, health communication training and even the medical or health humanities.
The chapters in this volume bring together applied linguistic work using discourse analysis, corpus methods, conversation analysis, metaphor analysis, cognitive linguistics, multiculturalism research, interactional sociolinguistics, narrative analysis, and (im)politeness to make sense of a variety of international healthcare contexts and situations. These include:
-clinician-patient interactions
-receptionist-patient interactions
-online support forums
-online counselling
-public health communication
-media representations
-medical accounts
-diagnostic tools and definitions
-research interviews with doctors and patients
The volume demonstrates how linguistic analysis can not only improve understandings of the lived-experience of different illnesses, but also has implications for communications training, disease prevention, treatment and self-management, the effectiveness of public health messaging, access to appropriate care, professional mobility and professional terminology, among others..
Shameful Bodies
Authors: Lelwica Michelle Mary 
Published: February 2020

What happens when your body doesn’t look how it’s supposed to look, or feel how it’s supposed to feel, or do what it’s supposed to do? Who or what defines the ideals behind these expectations? How can we challenge them and live more peacefully in our bodies?
Shameful Bodies: Religion and the Culture of Physical Improvement explores these questions by examining how traditional religious narratives and modern philosophical assumptions come together in the construction and pursuit of a better body in contemporary western societies. Drawing on examples from popular culture such as self-help books, magazines, and advertisements, Michelle Mary Lelwica shows how these narratives and assumptions encourage us to go to war against our bodies—to fight fat, triumph over disability, conquer chronic pain and illness, and defy aging. Through an ethic of conquest and conformity, the culture of physical improvement trains us not only to believe that all bodily processes are under our control, but to feel ashamed about those parts of our flesh that refuse to comply with the cultural ideal. Lelwica argues that such shame is not a natural response to being fat, physically impaired, chronically sick, or old. Rather, body shame is a religiously and culturally conditioned reaction to a commercially-fabricated fantasy of physical perfection.
While Shameful Bodies critiques the religious and cultural norms and narratives that perpetuate external and internalized judgment and aggression toward “shameful” bodies, it also engages the resources of religions, especially feminist theologies and Buddhist thought/practice, to construct a more affirming approach to health and healing—an approach that affirms the diversity, fragility, interdependence, and impermanence of embodied life.
A study of the influence of tropospheric subsidence on spring and summer surface ozone concentrations at the JRC Ispra station in northern Italy
Authors: Kalabokas Pavlos , Jensen Niels Roland , Roveri Mauro , Hjorth Jens , Eremenko Maxim , Cuesta Juan , Dufour Gaëlle , Foret Gilles , Beekmann Matthias 
Published: February 2020

Abstract. The influence of tropospheric ozone on the surface ozone
concentrations is investigated at the monitoring station of JRC Ispra, based
on 10 years of measurements (2006–2015) of surface ozone data. In situ
hourly measurements of ozone and other air pollutants, meteorological
parameters, and weekly averaged 7Be (as an indicator of
upper-tropospheric–stratospheric influence) and 210Pb measurements (as
an indicator of boundary layer influence) have been used for the analysis. In
addition, IASI + GOME-2 and IASI ozone satellite data have also been used. It
is observed that frequently 7Be and ozone weekly peaks coincide, which
might be explained by the impact of deep atmospheric subsidence on surface
ozone, particularly during late spring and early summer. Based on this
observation, a detailed analysis of selected 7Be and ozone episodes
occurring during that period of the year has been performed in order to
further elucidate the mechanisms of tropospheric influence on the surface
pollutant concentrations. For the analysis, composite NOAA/ESRL reanalysis
synoptic meteorological charts in the troposphere have been used as well as
IASI satellite ozone measurements and NOAA HYSPLIT back trajectories. The
JRC station hourly measurements during subsidence episodes show very low
values of local pollution parameters (e.g., NOx, 222Rn,
nephelometer data, PM10), close to zero. Conversely, during these
periods ozone levels usually reach values around 45–60 ppb during the
afternoon hours but also show significantly higher values than the average
during the night and morning hours, which is a sign of direct tropospheric
influence on the surface ozone concentrations.