bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geomorphology and event-stratigraphy of recent mass-movement processes in Lake Hallstatt (UNESCO World Heritage Cultural Landscape, Austria)
Authors: Strasser Michael , Berberich T. , Fabbri S. , Hilbe M. , Huang J-J. S. , Lauterbach S. , Ortler M. , Rechschreiter H. , Brauer A. , Anselmetti F. , Kowarik K. 
Published: December 2019

Abstract

We report the first-ever basin-wide geomorphological characterization of a high-resolution bathymetry map in a steeply incised valley-occupying intra-mountainous lake in the Eastern Alps. The resulting new geomorphological map of Lake Hallstatt is then combined with high-resolution reflection seismic and sedimentary core analyses to document, characterize and date recent (<200 years) subaquatic landslides. The area is located in the UNESCO World Heritage Cultural Landscape of the Hallstatt–Dachstein area, famous for its well-documented medieval and prehistoric human settlement history. This allows us to calibrate observed mass-transport deposits (MTDs) in the high-resolution sedimentary archive (sedimentation rates
c.
0.5 cm a
−1
) of this deep lake dominated by clastic sedimentation.

The hydro-acoustic data document a multitude of different MTDs linked to rock falls, subaqueous slope failures and shore collapses. Sediment cores document laminated background sediments intercalated with distinct event deposits that can be linked to historically documented major flood events and moderately strong earthquakes. Our study suggests that the larger MTDs result from earthquake-triggered subaquatic delta slope instabilities and that the deeper subsurface provides evidence of even larger mass-movement processes, yet to be validated by longer cores. Thus, Lake Hallstatt is a potential natural laboratory for studying causes and consequences of subaquatic landslides in steeply incised intra-mountainous lakes and comparable fjord settings.
Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma
Authors: Perumal Deepak , Imai Naoko , Laganà Alessandro , Finnigan John , Melnekoff David , Leshchenko Violetta V. , Solovyov Alexander , Madduri Deepu , Chari Ajai , Cho Hearn Jay , Dudley Joel T. , Brody Joshua D. , Jagannath Sundar , Greenbaum Benjamin , Gnjatic Sacha , Bhardwaj Nina , Parekh Samir 
Published: December 2019

AbstractPurpose:Somatic mutations in cancer cells can give rise to novel protein sequences that can be presented by antigen-presenting cells as neoantigens to the host immune system. Tumor neoantigens represent excellent targets for immunotherapy, due to their specific expression in cancer tissue. Despite the widespread use of immunomodulatory drugs and immunotherapies that recharge T and NK cells, there has been no direct evidence that neoantigen-specific T-cell responses are elicited in multiple myeloma.Experimental Design:Using next-generation sequencing data we describe the landscape of neo-antigens in 184 patients with multiple myeloma and successfully validate neoantigen-specific T cells in patients with multiple myeloma and support the feasibility of neoantigen-based therapeutic vaccines for use in cancers with intermediate mutational loads such as multiple myeloma.Results:In this study, we demonstrate an increase in neoantigen load in relapsed patients with multiple myeloma as compared with newly diagnosed patients with multiple myeloma. Moreover, we identify shared neoantigens across multiple patients in three multiple myeloma oncogenic driver genes (KRAS, NRAS, and IRF4). Next, we validate neoantigen T-cell response and clonal expansion in correlation with clinical response in relapsed patients with multiple myeloma. This is the first study to experimentally validate the immunogenicity of predicted neoantigens from next-generation sequencing in relapsed patients with multiple myeloma.Conclusions:Our findings demonstrate that somatic mutations in multiple myeloma can be immunogenic and induce neoantigen-specific T-cell activation that is associated with antitumor activity in vitro and clinical response in vivo. Our results provide the foundation for using neoantigen targeting strategies such as peptide vaccines in future trials for patients with multiple myeloma.
Assessing Nurses' Adherence to the See-and-Treat Guidelines of Botswana's National Cervical Cancer Prevention Programme
Authors: Johnson Lauren G. , Ramogola-Masire Doreen , Teitelman Anne M. , Jemmott John B. , Buttenheim Alison M. 
Published: December 2019

Abstract
The see-and-treat approach for cervical cancer screening [visual inspection with acetic acid (VIA) followed by immediate cryotherapy] was first pilot tested in Botswana in 2009. Botswana's Ministry of Health and the Botswana-UPenn Partnership collaborated to expand see-and-treat to five additional sites throughout the country in 2014. The purpose of this study was to evaluate whether nurses’ adherence to guideline-based screening was maintained during scale-up. Therefore, we compared nurses’ adherence between the pilot and scaled-up sites and determined main drivers of nonadherence across all sites. We conducted a retrospective review of 6,644 medical charts from Botswana's National Cervical Cancer Prevention Programme between February 2014 and October 2015. Using multivariable regression modeled with generalized estimating equations, we determined whether nurses’ adherence to the see-and-treat guideline differed between the pilot and scale-up sites after controlling for significant covariates. Overall, adherence to the guideline was high (88.4%). Although the scaled-up sites had higher adherence compared with the pilot site (90.9% vs. 80.2%, respectively), the difference between sites was not statistically significant in the multivariable model (P = 0.221). Of the nonadherent clinical encounters, the three most frequent visit types were VIA not performed (178, 23.3%), VIA negative: HIV unknown (163, 21.3%), and VIA negative: HIV negative (144, 18.9%). The most common reason for nonadherence was misspecification of follow-up times. Despite known challenges of scaling-up health innovations in resource-limited settings, our study shows that nurses maintained guideline-adherent care in Botswana's national see-and-treat program. The successful scale-up may have been attributable to the program's intensive quality assurance monitoring.
"Ou a morte ou o livro": a escrita em Marguerite Duras
Authors: Rangel Tatiane de Souza França 
Published: December 2019

Nas primeiras páginas de O Amante (1984), livro que trouxe à Marguerite Duras o Prix Goncourt do mesmo ano, uma frase se repete: “Deixe-me contar de novo”. A obra durassiana, como um todo, parece funcionar nesse movimento de maré: um (re)contar que passeia por diferentes tipos de representação, desde a página até as telas de cinema. Uma questão começa a se desenhar: por que seria preciso contar e recontar inúmeras vezes, mudando a forma narrativa, mudando o aparato representativo, facetas de uma mesma – ou de várias mesmas – histórias? O que seria escrever para uma autora que, ao ensaiar sobre a escrita, diz que ao se achar no fundo de um buraco, numa solidão quase total, se descobre que só a escrita pode nos salvar? É no encalço dessas interrogações que o presente artigo se desenrola. No encontro entre duas obras, O amante (1984) e Agatha (1981), busca-se pensar no que essa escrita, única salvadora, representa, e na relação que ela configura com o corpo de quem escreve quando se acha, só, no fundo de um buraco.
Unintended Consequences of Adjacency Claims
Authors: Bradley Miriam 
Published: December 2019

Abstract
This article examines the role of adjacency claims in the development of a norm for the international protection of internally displaced persons (IDP s). Consistent with existing scholarship on adjacency claims, the construction of analogies between refugee protection and IDP protection was instrumental in garnering broad international acceptance of the IDP protection norm. However, these same analogies had an impact beyond the abstract acceptance of the norm. They were used to justify the expansion of the mandate of the UN Refugee Agency (UNHCR) to encompass IDP s, and they shaped the way UNHCR understands and implements IDP protection. UNHCR replicated its policy approach from refugees to IDP s, generating a dysfunctional approach to IDP protection. Therefore, adjacency claims can have an effect beyond garnering support for new norms, and may result in suboptimal governance arrangements for implementing those norms.
Mussolini’s ‘Third Rome’, Hitler’s Third Reich and the Allure of Antiquity: Classicizing Chronopolitics as a Remedy for Unstable National Identity?
Authors: Roche Helen 
Published: December 2019

Abstract
While it is generally acknowledged that fascist movements tend to glorify the national past of the country in which they arise, sometimes, fascist regimes seek to resurrect a past even more ancient, and more glorious still; the turn towards ancient Greece and Rome. This phenomenon is particularly marked in the case of the two most powerful and indisputably ‘fascist’ regimes of all: Benito Mussolini’s Italy and Adolf Hitler’s Germany. The author suggests that this twin turn towards antiquity was no mere accident, but was rather motivated by certain commonalities in national experience. By placing these two fascist regimes alongside each other and considering their seduction by antique myths in tandem, it is argued that – without putting forward some kind of classicizing Sonderweg – we can better appreciate the historic rootedness of this particular form of ‘chronopolitics’ in a complex nexus of political and social causes, many of which lie far deeper than the traumatic events of the Great War and its aftermath.
Editorial Introduction: Fascist and National Socialist Antiquities and Materialities from the Interwar Era to the Present Day
Authors: Roche Helen , Bartolini Flaminia , Schmalz Timothy J. 
Published: December 2019

Abstract
Fascist Italy and Nazi Germany, along with other twentieth-century authoritarian regimes, have often attempted to create consensus through propagandistic reinterpretations of the classical past. The Fascist appropriation of romanità and Nazi philhellenism were not only conditioned by prior cultural receptions of antiquity, but were also a key political tool in motivating and mobilising citizens to fulfil the aims of the fascist state. Once Fascism and Nazism had fallen, the material legacies of both regimes then became the object of destruction, reinterpretation and memory work. Thus, the archaeological and architectural heritage of these regimes, now tainted by their ideology, has not only suffered the consequences of damnatio memoriae in the aftermath of regime change, but continues even today to inflame contemporary public debate. This special issue represents the product of an interdisciplinary workshop exploring these themes, which was held at Sidney Sussex College, Cambridge, on 8 June 2018.
The Timor Sea Treaty: An Australian Perspective
Authors: Huntley Ben , Telec Amelia , Whyatt Justin 
Published: December 2019

Abstract
In March 2018, Australia and Timor-Leste signed a treaty in a ceremony in New York, witnessed by the UN Secretary-General, which will permanently delimit their maritime boundaries and establish a special regime over the Greater Sunrise gas fields in the Timor Sea. Not only does this Treaty represent an important milestone in the relationship between the two States, it also marks the successful conclusion of the first-ever conciliation conducted under the dispute resolution provisions of the UN Convention on the Law of the Sea (unclos). How this untested process led to the ending of the long-running and complex dispute over maritime delimitation in the Timor Sea merits further consideration. This article will provide an Australian perspective on these historic proceedings, focussing on how the process led to a positive outcome for the Parties and the key features of the agreement reached. We will begin by outlining briefly the background to the dispute between Australia and Timor-Leste. We will then consider the nature of the conciliation provisions of unclos, and what makes them unique. We will then explore some of the procedural aspects of the Timor-Leste/Australia Conciliation which led to a successful outcome in the proceedings. Finally, we will outline the key elements of the agreement reached between the Parties.
Social Protection as Dialogue in Transnational Legal Ordering
Authors: Lim Jennifer Daphne 
Published: December 2019

Abstract
Recently, ‘social protection’ has attracted attention as a powerful tool for poverty alleviation. For example, Target 1.3 of the 2015 UN Sustainable Development Goals calls for nationally appropriate social protection systems for all. However, ‘social protection’ has defied common definition to date. Rather, it can denote very different anti-poverty approaches, policies, beneficiaries and end goals. This lack of clarity has led to confusion and contestation between international institutional actors, including the International Monetary Fund and International Labour Organization.
By historically tracing the development of ‘social protection’ within the economics, human rights, development and labour ‘transnational legal orders’, this article argues that different usages reflect diverse and enduring discourses about the root causes of poverty and most effective solutions. In particular, neoliberalism continues to inform the work of international financial institutions, in a way that is misaligned with human rights understandings. This article proposes a new paradigm to advance engagement between different orders, being ‘social protection as dialogue’, to achieve more meaningful legal developments.
Effects of a Digital Self-care Intervention in Adults with COPD: A Pilot Study
Authors: Bugajski Andrew , Frazier Susan K. , Cousin Lakeshia , Rechenberg Kaitlyn , Brown Jaelyn , Lengerich Alexander J. , Moser Debra K. , Lennie Terry A. 
Published: December 2019

Self-care improves quality of life, and reduces exacerbations and mortality risk in people with chronic obstructive pulmonary disease (COPD). The purpose of this report is to describe the development and testing of the feasibility and acceptability of a digital, educational self-care intervention designed to improve self-care ability, adherence, knowledge, somatic symptoms, anxiety, and depressive symptoms. This pilot study was a quasi-experimental, repeated measures design. Self-care behaviors were identified, and educational modules were developed and built into a web-based platform. Twenty participants were enrolled to determine feasibility, acceptability, and preliminary efficacy. The intervention was deemed acceptable and feasible as evidenced by > 95% completion rates and high degree of participation. Overall, the intervention was well received and is feasible for future home-based interventions in those with COPD. Results included significant improvements in adherence and knowledge, and significant associations between self-care ability, adherence, and depressive symptoms.
Combination of 16S rRNA and procalcitonin in diagnosis of neonatal clinically suspected sepsis
Authors: Yu Renqiang , Zhou Qin , Jiang Shanyu , Mei Yingzi , Wang Min 
Published: December 2019

Objective To investigate the application of 16S rRNA in diagnosing patients with neonatal sepsis. Methods We studied 60 consecutive neonatal patients with clinically suspected sepsis and 20 non-infective cases as controls. All patients were diagnosed with sepsis by clinical and experimental criteria. Clinical characteristics were recorded and 16S rRNA sequencing was conducted for all patients. The sensitivity, specificity, and accuracy of the detection methods were analyzed. Results The detection limit of 16S rRNA sequencing was 1 × 102 CFU/mL. For suspected sepsis, the positive rate of 16S rRNA detection was 93.3%, which was similar to that of procalcitonin detection (85%), and was significantly higher than that of bacterial culture (51.7%). The specificity of procalcitonin detection (74.1%) was significantly lower than that of 16S rRNA detection (100%). Moreover, the combination of 16S rRNA and procalcitonin detection showed a sensitivity of 100%, specificity of 74.1%, and accuracy of 92.0%. For proven sepsis, the sensitivity and specificity of 16S rRNA detection were both 100.0%, and those for procalcitonin were 87.1% and 87.0%, respectively. Conclusion Detection of 16S rRNA has high sensitivity and specificity in diagnosing sepsis. The combination of 16S rRNA and procalcitonin has even better sensitivity with acceptable specificity.
Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation
Authors: Stevens Alexandra M. , Xiang Michael , Heppler Lisa N. , Tošić Isidora , Jiang Kevin , Munoz Jaime O. , Gaikwad Amos S. , Horton Terzah M. , Long Xin , Narayanan Padmini , Seashore Elizabeth L. , Terrell Maci C. , Rashid Raushan , Krueger Michael J. , Mangubat-Medina Alicia E. , Ball Zachary T. , Sumazin Pavel , Walker Sarah R. , Hamada Yoshimasa , Oyadomari Seiichi , Redell Michele S. , Frank David A. 
Published: December 2019

Key Points
Atovaquone induces AML blast apoptosis and prolongs survival in AML xenografts. Atovaquone induces proapoptotic signaling and inhibits the mTOR pathway through upregulation of ATF4 and also suppresses OXPHOS.
Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting
Authors: Slomp Anne , Moesbergen Laura M. , Gong Jia-nan , Cuenca Marta , von dem Borne Peter A. , Sonneveld Pieter , Huang David C. S. , Minnema Monique C. , Peperzak Victor 
Published: December 2019

Key PointsAmplification of 1q21 correlates with increased sensitivity to MCL-1 inhibitor S63845 in primary MM cells. Poor-prognosis MM is particularly sensitive to MCL-1 inhibition, partially independent of 1q21 amplification status.
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles
Authors: Akhtar Shahnaz , Khan Qasim , Anwar Shahzad , Ali Ghafar , Maqbool Muhammad , Khan Maaz , Karim Shafqat , Gao Lan 
Published: December 2019

AbstractWe present a comparative study of the toxicity of polyethylene glycol (PEG)–coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modified with polyethylene glycol. To investigate the morphology of the prepared samples, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA), and electron microscopy techniques were employed. Structural analyses confirmed the formation of polycrystalline cobalt ferrite nanoparticles with diameters in the range 20–25 nm and nanospheres in the range 80–100 nm, respectively. Kunming SPF mice (female, 6–8 weeks old) were used to investigate the toxicity induced by cobalt ferrite nanoparticles and nanospheres in different organs of the mice. Biodistribution studies, biochemical indices, histopathological assessments, inflammatory factors, oxidation and antioxidant levels, and cytotoxicity tests were performed to assess the toxicity induced by cobalt ferrite nanoparticles and nanospheres in mice. Cobalt ferrite nanospheres were found to be more toxic than the nanoparticles and curcumin was proved to be a good healing agent for the toxicity induced by PEG-coated cobalt ferrite nanomaterials in mice.
The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis
Authors: Vacca Francesca , Barca Amilcare , Gomes Ana S. , Mazzei Aurora , Piccinni Barbara , Cinquetti Raffaella , Del Vecchio Gianmarco , Romano Alessandro , Rønnestad Ivar , Bossi Elena , Verri Tiziano 
Published: December 2019

Abstract
Background
Peptide transporter 1 (PepT1, alias Slc15a1) mediates the uptake of dietary di/tripeptides in all vertebrates. However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole genome duplication event(s) that occurred during their evolution leading to a more complex paralogue gene repertoire than in higher vertebrates (tetrapods).

Results
Here, we describe a novel di/tripeptide transporter in the zebrafish (Danio rerio), i.e., the zebrafish peptide transporter 1a (PepT1a; also known as Solute carrier family 15 member a1, Slc15a1a), which is a paralogue (78% similarity, 62% identity at the amino acid level) of the previously described zebrafish peptide transporter 1b (PepT1b, alias PepT1; also known as Solute carrier family 15 member 1b, Slc15a1b). Also, we report a basic analysis of the pept1a (slc15a1a) mRNA expression levels in zebrafish adult tissues/organs and embryonic/early larval developmental stages. As assessed by expression in Xenopus laevis oocytes and two-electrode voltage clamp measurements, zebrafish PepT1a, as PepT1b, is electrogenic, Na+-independent, and pH-dependent and functions as a low-affinity system, with K0.5 values for Gly-Gln at − 60 mV of 6.92 mmol/L at pH 7.6 and 0.24 mmol/L at pH 6.5 and at − 120 mV of 3.61 mmol/L at pH 7.6 and 0.45 mmol/L at pH 6.5. Zebrafish pept1a mRNA is highly expressed in the intestine and ovary of the adult fish, while its expression in early development undergoes a complex trend over time, with pept1a mRNA being detected 1 and 2 days post-fertilization (dpf), possibly due to its occurrence in the RNA maternal pool, decreasing at 3 dpf (~ 0.5-fold) and increasing above the 1–2 dpf levels at 4 to 7 dpf, with a peak (~ 7-fold) at 6 dpf.

Conclusions
We show that the zebrafish PepT1a-type transporter is functional and co-expressed with pept1b (slc15a1b) in the adult fish intestine. Its expression is also confirmed during the early phases of development when the yolk syncytial layer is present and yolk protein resorption processes are active. While completing the missing information on PepT1-type transporters function in the zebrafish, these results open to future investigations on the similar/differential role(s) of PepT1a/PepT1b in zebrafish and teleost fish physiology.