bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chirurgische Therapie von Leber- und Pankreasmetastasen von Nierenzellkarzinomen
Authors: Bauschke Astrid , Altendorf-Hofmann Annelore , Ali Deeb Aladdin , Kissler Herman , Tautenhahn Hans-Michael , Settmacher Utz 
Published: January 2021

Zusammenfassung
Hintergrund
Der Stellenwert der chirurgischen Therapie hepatopankreatischer Metastasen des oligometastasierten Nierenzellkarzinoms ist Gegenstand der aktuellen Diskussion.

Material und Methoden
Wir berichten über 51 Patienten, von denen 33 wegen Lebermetastasen und 19 wegen Pankreasmetastasen im Zeitraum von 1995 bis 2018 operiert wurden.

Ergebnisse
Die 5‑Jahres-Überlebensrate aller Patienten nach Leberteilresektion war statistisch signifikant geringer (38 %, mediane Überlebenszeit 34 Monate) als nach Pankreasresektion (69 %, mediane Überlebenszeit 69 Monaten; p = 0,017). 21 Patienten haben bislang die Metastasenentfernung länger als 5 Jahr überlebt, 4 Patienten länger als 10 Jahre. Bei den R0-resezierten Patienten wurden Rezidive in 13 Fällen nach Leber- und 9 Fällen nach Pankreasresektion beobachtet. Die kumulative Rezidivrate nach 5 Jahren betrug bei der Leber 38 % und beim Pankreas 57 %. Bei R0-Leberteilresektionen erwiesen sich ein Intervall von <24 Monaten zwischen Nephrektomie und Leberresektion sowie multiple Metastasen als negative Prognosefaktoren.

Diskussion
Unsere Ergebnisse gestatten eine aktive chirurgische Strategie in der Behandlung hepatopankreatischer Metastasen oligometastasierter Nierenzellkarzinome, insbesondere bei kompletter Resektion solitärer, metachroner Metastasen. Wiederholte Eingriffe bei komplett resektablen Metastasen führen zu langen tumorfreien Intervallen und tragen damit zu guten Langzeitergebnissen bei.
Endoscopic preperitoneal parastomal hernia repair (ePauli repair) : an observational study
Authors: Lambrecht Jan Roland 
Published: January 2021

Abstract
Background
Aspiring endoscopic surgery with extraperitoneal mesh application to avoid adhesion and pain from mesh fixation, we adopted the principles of the open Pauli repair of parastomal hernia (PSH). We have termed the procedure ePauli repair. The aim of this account is to inform about feasibility and adverse reactions.

Methods
Patients with PSH selected for ePauli repair with transversus abdominis release (TAR) were enrolled in a prospective observational study. Patients were operated with laparoscopic or robotic assistance and endoscopic Rives-Stoppa repair in cases with concomitant midline hernia. Coated meshes or a buffer mesh was used in the retromuscular pocket for this modification of the Sugarbaker principle.

Results
Fifteen patients were included: six patients were operated laparoscopically and nine patients with robotic assistance. The median age of the stomas was 33 months (7–313). Five PSHs were recurrent after previous repairs. Median operating time without midline hernia repair was 156 min (107–233) and with midline hernia repair 241 min (176–286). One serosa lesion arose during operation, prompting intraoperative revision of the ostomy without postoperative morbidity. Two patients had postoperative obstruction and were readmitted to operation: one with multiple adhesions and one had kinking of the stoma bowel caused by insufficient incision of the transversalis fascia. No infections or seromas have been observed. One patient had discoloring of the flank with spontaneous remission, and one patient had recurrence. Median postoperative admission time was 3 days (1–19). Median follow-up is 10 months (0–27).

Conclusions
ePauli repair is technically challenging but feasible. With our limited experience, we are encouraged with the pain, complication, and functional summary after ePauli repair and hopeful for the recurrence profile. ePauli/TAR is not for every patient or every surgeon and whether it should be restrained to recurrent PSH or be offered as first-line treatment for PSH is disputable.
Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon
Authors: Ramharter Michael , Agnandji Selidji T. , Adegnika Ayôla A. , Lell Bertrand , Mombo-Ngoma Ghyslain , Grobusch Martin P. , McCall Matthew , Muranaka Riko , Kreidenweiss Andrea , Velavan Thirumalaisamy P. , Esen Meral , Schaumburg Frieder , Alabi Abraham , Druml Christiane , Mordmüller Benjamin , Köhler Carsten , Kremsner Peter G. 
Published: January 2021

SummaryMedical research in sub-Saharan Africa is of high priority for societies to respond adequately to local health needs. Often enough it remains a challenge to build up capacity in infrastructure and human resources to highest international standards and to sustain this over mid-term to long-term periods due to difficulties in obtaining long-term institutional core funding, attracting highly qualified scientists for medical research and coping with ever changing structural and political environments. The Centre de Recherches Médicales de Lambaréné (CERMEL) serves as model for how to overcome such challenges and to continuously increase its impact on medical care in Central Africa and beyond. Starting off as a research annex to the Albert Schweitzer Hospital in Lambaréné, Gabon, it has since then expanded its activities to academic and regulatory clinical trials for drugs, vaccines and diagnostics in the field of malaria, tuberculosis, and a wide range of poverty related and neglected tropical infectious diseases. Advancing bioethics in medical research in Africa and steadily improving its global networks and infrastructures, CERMEL serves as a reference centre for several international consortia. In close collaboration with national authorities, CERMEL has become one of the main training hubs for medical research in Central Africa. It is hoped that CERMEL and its leitmotiv “to improve medical care for local populations” will serve as an inspiration to other institutions in sub-Saharan Africa to further increase African capacity to advance medicine.
Application of radar data assimilation on convective precipitation forecasts based on water vapor retrieval
Authors: He Zhixin , Wang Dongyong , Qiu Xuexing , Jiang Yang , Li Huimin , Shu Aiqing 
Published: January 2021

AbstractBased on a short-time heavy rainfall in Anhui and the weather research and forecasting (WRF) model, the water vapor in the initial field of the model is retrieved using the statistical relationships of the reflectivity factor from the Doppler weather radar with the relative humidity and hydrometeor. Three-dimensional variational (3DVAR) assimilation method is used to assimilate the radar reflectivity factor and radial velocity, and then the impact of assimilating retrieved water vapor on the analysis and forecast of the torrential rain is assessed. The results show that, after assimilating the retrieved water vapor, the water vapor field in the model is significantly improved. The water vapor content in the middle layer of the model in the analyzed field is increased, corresponding well with the convective region. Meanwhile, the precipitation distribution during this weather process is successfully simulated. The mesoscale characteristics are better presented by the imageries of radar reflectivity factor, and false echoes are partially reduced. Besides, the prediction of short-time heavy rainfall regions is closer to the actual observations. After assimilating the retrieved water vapor, the simulated one-hour accumulated rainfall is closer to the actual observation, and the fraction skill score (FSS) is higher.
Local convergence of tensor methods
Authors: Doikov Nikita , Nesterov Yurii 
Published: January 2021

AbstractIn this paper, we study local convergence of high-order Tensor Methods for solving convex optimization problems with composite objective. We justify local superlinear convergence under the assumption of uniform convexity of the smooth component, having Lipschitz-continuous high-order derivative. The convergence both in function value and in the norm of minimal subgradient is established. Global complexity bounds for the Composite Tensor Method in convex and uniformly convex cases are also discussed. Lastly, we show how local convergence of the methods can be globalized using the inexact proximal iterations.
The roles of histone deacetylases in kidney development and disease
Authors: Liu Hongbing 
Published: January 2021

AbstractHistone deacetylases (HDACs) are important epigenetic regulators that mediate deacetylation of both histone and non-histone proteins. HDACs, especially class I HDACs, are highly expressed in developing kidney and subject to developmental control. HDACs play an important role in kidney formation, especial nephron progenitor maintenance and differentiation. Several lines of evidence support the critical role of HDACs in the development and progression of various kidney diseases. HDAC inhibitors (HDACis) are very effective in the prevention and treatment of kidney diseases (including kidney cancer). A better understanting of the molecular mechanisms underlying the role(s) of HDACs in the pathogenesis and progression of renal disease are likely to be of great help in developing more effective and less toxic selective HDAC inhibitors and combinatorial therapeutics.
Tensor-Free Proximal Methods for Lifted Bilinear/Quadratic Inverse Problems with Applications to Phase Retrieval
Authors: Beinert Robert , Bredies Kristian 
Published: January 2021

AbstractWe propose and study a class of novel algorithms that aim at solving bilinear and quadratic inverse problems. Using a convex relaxation based on tensorial lifting, and applying first-order proximal algorithms, these problems could be solved numerically by singular value thresholding methods. However, a direct realization of these algorithms for, e.g., image recovery problems is often impracticable, since computations have to be performed on the tensor-product space, whose dimension is usually tremendous. To overcome this limitation, we derive tensor-free versions of common singular value thresholding methods by exploiting low-rank representations and incorporating an augmented Lanczos process. Using a novel reweighting technique, we further improve the convergence behavior and rank evolution of the iterative algorithms. Applying the method to the two-dimensional masked Fourier phase retrieval problem, we obtain an efficient recovery method. Moreover, the tensor-free algorithms are flexible enough to incorporate a priori smoothness constraints that greatly improve the recovery results.
Asynchronous session subtyping as communicating automata refinement
Authors: Bravetti Mario , Zavattaro Gianluigi 
Published: January 2021

AbstractWe study the relationship between session types and behavioural contracts, representing Communicating Finite State Machines (CFSMs), under the assumption that processes communicate asynchronously. Session types represent a syntax-based approach for the description of communication protocols, while behavioural contracts, formally expressing CFSMs, follow an operational approach. We show the existence of a fully abstract interpretation of session types into a fragment of contracts that maps session subtyping into binary compliance-preserving CFSMs/behavioural contract refinement. In this way, on the one hand, we enrich the theory of session types with an operational characterization and, on the other hand, we use recent undecidability results for asynchronous session subtyping to obtain an original undecidability result for asynchronous CFSMs/behavioural contract refinement.
N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target
Authors: Mackey John R. , Lai Justine , Chauhan Utkarsh , Beauchamp Erwan , Dong Wei-Feng , Glubrecht Darryl , Sim Yie-Wei , Ghosh Sunita , Bigras Gilbert , Lai Raymond , Berthiaume Luc G. 
Published: January 2021

Abstract
Purpose
N-myristoyltransferases 1 and 2 (NMT1 and NMT2) catalyze the addition of 14-carbon fatty acids to the N-terminus of proteins. Myristoylation regulates numerous membrane-bound signal transduction pathways important in cancer biology and the pan-NMT inhibitor PCLX-001 is approaching clinical development as a cancer therapy. The tissue distribution, relative abundances, and prognostic value of the two human NMTs remain poorly understood.

Methods
We generated and validated mutually exclusive monoclonal antibodies (mAbs) specific to human NMT1 and NMT2. These mAbs were used to perform immunohistochemical analysis of the abundance and distribution of NMT1 and NMT2 in normal breast epithelial samples and a large cohort of primary breast adenocarcinomas from the BCIRG001 clinical trial (n = 706).

Results
NMT1 protein was readily quantified in normal and most transformed breast epithelial tissue and was associated with higher overall histologic grade, higher Ki67, and lower hormone receptor expression. While NMT2 protein was readily detected in normal breast epithelial tissue, it was undetectable in the majority of breast cancers. Detectable NMT2 protein correlated with significantly poorer overall survival (hazard ratio 1.36; P = 0.029) and worse biological features including younger age, higher histologic grade, lower hormone receptor expression, higher Ki67, and p53 positivity. Treatment of cultured breast cancer cells with PCLX-001 reduced cell viability in vitro. Daily oral administration of PCLX-001 to immunodeficient mice bearing human MDA-MB-231 breast cancer xenografts produced significant dose-dependent tumor growth inhibition in vivo.

Conclusions
These results support further evaluation of NMT immunohistochemistry for patient selection and clinical trials of NMT inhibition in breast cancer patients.
Controlled-release N fertilizer to mitigate ammonia volatilization from double-cropping rice
Authors: Tian Chang , Zhou Xuan , Ding Zheli , Liu Qiang , Xie Guixian , Peng Jianwei , Rong Xiangming , Zhang Yuping , Yang Yong , Eissa Mamdouh A. 
Published: January 2021

AbstractControlled-release nitrogen fertilizer (CRNF) can effectively enhance crop yields and raise the efficiency of nitrogen fertilizer in agroecosystems. In the present study, the volatilization of NH3was determined by airflow enclosure chamber technique after the application of different CRNF rates in double-cropping rice fields in southern China for continuous 3 years. The early and late season rice (ESR and LSR) were cultivated each year. The results showed that the total NH3volatilization losses ranged from 25 to 56 kg N ha−1in ESR and from 32 to 61 kg N ha−1in LSR. The loss of N to the total applied N ranged from 12 to 29% in ESR and from 12 to 27% in LSR. The application of CRNF significantly reduced the cumulative NH3volatilization losses by 20–43% for ESR and by 20–32% for LSR compared with conventional urea application. CRNF in LSR was less effective to reduce NH3volatilization than that in ESR. Furthermore, the application of 80% of N rate in the form of CRNF gave higher grain yield and apparent nitrogen recovery efficiency (ANRE) than that of application of 100% of N rate from conventional urea. CRNF can effectively reduce NH3volatilization, and increase rice yield and ANRE. Considering higher price of CRNF, the application of CRNF at lower (20% applied N) rate than conventional urea in LSR may be a reasonable fertilization strategy for improving N use efficiency, environment effectiveness, and sustaining the development of rice production systems in double-cropping rice.
Restoration-mediated alteration induces substantial structural changes, but negligible shifts in functional and phylogenetic diversity of a non-target community: a case study from a soda pan
Authors: Boda Pál , Bozóki Tamás , Krasznai-K. Eszter Á. , Várbíró Gábor , Móra Arnold , Csabai Zoltán 
Published: January 2021

AbstractStream macroinvertebrates, as non-target organisms, may face with either a single or a complex stressor during a restoration treatment. We quantified the structural, phylogenetic, and functional responses to both single (water retention) and complex (water retention and grazing) stressors and analysed how the ecological quality changes, in order to reveal the potential unwanted consequences in a soda pan restoration. Species composition has been restructured and taxonomic diversity decreased significantly as a response to the complex stressor, while they did not change under the single stress. Neither the single nor the complex stressor influenced the phylogenetic diversity. Functional diversity showed mainly no or reversible changes. Changes in diversity metrics induced changes in Ecological Quality Ratios, but the ecological state decreased only under the complex stressor. Our results suggest that different facets of alpha diversity (taxonomic, functional and phylogenetic) are complementary and provide different information about community assembly against different stresses. We can support the opinion that taxon, phylogenetic and functional diversity are proper metrics in their own way to assess the impact of stress, but it is necessary to apply them together. Ecological knowledge of this paper could be considered throughout future conservation planning and enhance restoration success in aquatic environments.
Preparatory effects of problem solving versus studying examples prior to instruction
Authors: Hartmann Christian , van Gog Tamara , Rummel Nikol 
Published: January 2021

AbstractThe Productive Failure (PF) approach prompts students to attempt to solve a problem prior to instruction – at which point they typically fail. Yet, research on PF shows that students who are involved in problem solving prior to instruction gain more conceptual knowledge from the subsequent instruction compared to students who receive the instruction first. So far, there is no conclusive evidence, however, that the beneficial effects of PF are explained by the attempt to generate one’s own solutions prior to instruction. The literature on example-based learning suggests that observing someone else engaging in problem-solving attempts may be an equally effective means to prepare students for instruction. In an experimental study, we compared a PF condition, in which students were actively engaged in problem solving prior to instruction, to two example conditions, in which students either observed the complete problem-solving-and-failing process of another student engaging in PF or looked at the outcome of this process (i.e., another student’s failed solution attempts). Rather than worked examples of the correct solution procedure, the students observed examples of failed solution attempts. We found that students’ own problem solving was not superior to the two example conditions. In fact, students who observed the complete PF process even outperformed students who engaged in PF themselves. Additional analyses revealed that the students’ prior knowledge moderated this effect: While students who observed the complete PF process were able to take advantage of their prior knowledge to gain more conceptual knowledge from the subsequent instruction, prior knowledge did not affect students’ post-test performance in the PF condition.
Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transfer coefficient?
Authors: Olughu Williams , Galbraith Duncan , Paget Cillian , Ruscoe Steve , Smith Josh , Mason Alison 
Published: January 2021

AbstractThe volumetric oxygen mass transfer coefficient ($$k_{l} a$$

k
l

a

) is an essential parameter in aerobic high-cell density fermentation where the availability of oxygen to growing microorganisms is a limiting factor. Bioprocess teams looking to scale-up/down between the Eppendorf BioBLU 0.3f single-use vessel and the BioFlo® 320 reusable vessel bioreactors may find it challenging using a matched $$k_{l} a$$

k
l

a

. The maximum $$k_{l} a$$

k
l

a

of the BioFlo® 320 reusable bioreactor was 109 h−1, which was approximately twice that of the BioBLU 0.3f single-use vessel. The results here show no overlap in $$k_{l} a$$

k
l

a

values when both bioreactors were compared and thus conclude that scalability based on $$k_{l} a$$

k
l

a

is not viable. The maximum $$k_{l} a$$

k
l

a

of the Eppendorf BioBLU 0.3f single-use reported here was 47 h−1 compared to that of the manufacturer’s value of 2500 h−1, indicating a 53-fold difference. This discrepancy was attributed to the incompatible sulfite addition method used by the manufacturer for estimation.
A MECS redistribution algorithm for SDN-enable MEC using response time and transmission overhead
Authors: Wu Runze , Ao Xiang , Fan Bing , Hu Hailin 
Published: January 2021

AbstractThe software-defined networks-enable mobile edge computing (SDN-enable MEC) architecture, which integrates SDN and MEC technologies, realizes the flexibility and dynamic management of the underlying network resources by the MEC, reduces the distance between the access terminal and computing resources and network resources, and increases the terminal's access to resources. However, the static distribution relationship between MEC servers (MECSs) and controllers in the multi-controller architecture may result in unbalanced load distribution among the controllers, which would degrade network performance. In this paper, a multi-objective optimization MECS redistribution algorithm (MOSRA) is proposed to decrease the response time and overhead. A controller response time model and link transmit overhead model are introduced as basis of an evolutionary algorithm which is proposed to optimize MECS redistribution. The proposed algorithm aims to select an available sub-optimizes individual by using a strategy based coordination transformation from Pareto Front. That is, when the master controller of the MECS is redistributed, both of the network overhead of the MECS to the controller and the response time of the controller to the MECS processing request are optimized. Finally, the simulation results demonstrate that the MOSRA can solve the redistribution problem in different network load levels and different network sizes within the effective time, and has a lower control plane response time, while making the edge network plane transmission overhead lower, compared with other algorithms
.
Partitioning Behavior and Interfacial Activity of Phenolic Acid Derivatives and their Impact on β-Lactoglobulin at the Oil-Water Interface
Authors: Bock Alina , Steinhäuser Ulrike , Drusch Stephan 
Published: January 2021

AbstractProteins are able to stabilize dispersed food systems due to their amphiphilic nature, acting as emulsifiers. Their interfacial properties can be influenced by different methods, including the formation of protein-phenol nanocomplexes. In this study, the interfacial behavior of phenolic compounds and protein-phenol nanocomplexes was first characterized according to the oil-water partitioning behavior of phenolic acid derivatives according to their molecular structure and its impact on interfacial tension. The influence of the phenolic compounds on protein film formation and its properties by dilatational rheology was then evaluated. The most phenolic acid derivatives are predominantly present in the aqueous phase. Despite their hydrophobic benzene body, weak interfacial activity was observed depending on their chemical structure. This result supports possible protein-phenol nanocomplex formation in the aqueous phase and possible interactions at the oil-water interface. Protein-phenol nanocomplexes showed decreased interfacial adsorption properties and decreased viscoelastic interfacial behavior, depending on the expansion of the delocalized π-electrons in the phenol.