bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case for the growth of ancient ooids within the sediment pile
Authors: Anderson Noah T. , Cowan Clinton A. , Bergmann Kristin D. 
Published: August 2020

ABSTRACT
In modern ooid-forming environments in the Caribbean, aerobic respiration of organic matter below the sediment–water interface drives an increase in pCO2 and a corresponding decrease in carbonate saturation state (Ω) that creates shallow sediment porewater that is neutral or slightly caustic to carbonate. The locus of ooid growth, therefore, is presumed to be in the water column during suspension, where supersaturation with respect to calcium carbonate is the norm. In the past, however, during conditions of low aqueous O2, high Ω, or low organic-matter input, the shallow sub-sediment marine burial environment was conducive to carbonate precipitation.
Here we present petrographic and electron probe microanalyzer (EPMA) data from exquisitely preserved oolites through time that suggests that some ancient ooids may have grown within the sediment pile. We propose that each increment of ooid cortical growth originated as incipient isopachous marine cement formed during shallow burial within migrating ooid dunes. After a period of burial (∼ weeks to months), ooids were remobilized and rounded during bedload transport.
This “bedform model” for ooid growth explains: 1) why ancient ooids are not limited by the precipitation–abrasion balance that appears to prohibit modern tangential Caribbean ooids from achieving grain sizes larger than coarse sand, 2) the radial crystal fabric that defines the internal structure of many ancient ooids, and 3) the first-order correlation of the abundance of large and giant ooids in the rock record to periods with predicted high porewater Ω. This model implies that photosynthetic microbes were unimportant for growth of large and giant ooid but it remains agnostic to the effect of other microbes. The physical and chemical milieu of modern marine ooid-forming environments is perhaps not the best analogue for ancient ooid-forming environments; this should be considered when using ancient ooids to reconstruct secular trends in ocean chemistry.
A Semianalytical Approach for Analysis of Wells Exhibiting Multiphase Transient Linear Flow: Application to Field Data
Authors: Hamdi Hamidreza , Behmanesh Hamid , Clarkson Christopher R. 
Published: August 2020

Summary
Rate-transient analysis (RTA) is a useful reservoir/hydraulic fracture characterization method that can be applied to multifractured horizontal wells (MFHWs) producing from low-permeability (tight) and shale reservoirs. In this paper, we applied a recently developed three-phase RTA technique to the analysis of production data from an MFHW completed in a low-permeability volatile oil reservoir in the Western Canadian Sedimentary Basin.
This RTA technique is used to analyze the transient linear flow regime for wells operated under constant flowing bottomhole pressure (BHP) conditions. With this method, the slope of the square-root-of-time plot applied to any of the producing phases can be used to directly calculate the linear flow parameter xfk without defining pseudovariables. The method requires a set of input pressure/volume/temperature (PVT) data and an estimate of two-phase relative permeability curves. For the field case studied herein, the PVT model is constructed by tuning an equation of state (EOS) from a set of PVT experiments, while the relative permeability curves are estimated from numerical model history-matchingresults.
The subject well, an MFHW completed in 15 stages, produces oil, water, and gas at a nearly constant (measured downhole) flowing BHP. This well is completed in a low-permeability,near-critical volatile oil system. For this field case, application of the recently proposed RTA method leads to an estimate of xfk that is in close agreement (within 7%) with the results of a numerical model history match performed in parallel. The RTA method also provides pressure–saturation (P–S) relationships for all three phases that are within 2% of those derived from the numerical model. The derived P–S relationships are central to the use of other RTA methods that require calculation of multiphase pseudovariables.
The three-phase RTA technique developed herein is a simple-yet-rigorous and accurate alternative to numerical model history matching for estimating xfk when fluid properties and relative permeability data are available.
Frequent fragility of randomized controlled trials for HCC treatment
Authors: Hao Zhang , Jingtao Li , Zeng Wenting 
Published: August 2020

Abstract
Background: The fragility index (FI) of trial results can provide a measure of confidence in the positive effects reported in randomized controlled trials (RCTs). The aim of this study was to calculate the FI of RCTs supporting HCC treatments.Methods: A methodological systematic review of RCTs in HCC treatments was conducted. Two-arm studies with randomized and positive results for a time-to-event outcome were eligible for the FI calculation.Results: A total of 6 trails were included in this analysis. The median FI was 0.5 (IQR 0-10). FI was ≤ 7 in 4 (66.7%) of 6 trials; in those trials the fragility quotient was ≤ 1%.Conclusion: Many phase 3 RCTs supporting HCC treatments have a low FI, which challenges the confidence in concluding the superiority of these drugs over control treatments.
Key stakeholder experiences of an integrated healthcare pilot in Australia: A thematic analysis
Authors: TRANKLE STEVEN , USHERWOOD TIM , ABBOTT PENELOPE , ROBERTS MARY , CRAMPTON MICHAEL , GIRGIS CHRISTIAN M , RISKALLAH JOHN , CHANG YASHU , SAINI JASPREET , REATH JENNIFER 
Published: August 2020

Abstract
BackgroundIn Australia and other developed countries, chronic illness prevalence is increasing, as are costs of healthcare, particularly hospital-based care. Integrating healthcare and supporting illness management in the community can be a means of preventing illness, improving outcomes and reducing unnecessary hospitalisation. Western Sydney has high rates of diabetes, heart and respiratory diseases and the NSW State Ministry of Health funded a range of key strategies through the Western Sydney Integrated Care Program (WSICP) to integrate care across hospital and community settings for patients with these illnesses. Complementing our previously reported analysis related to specific WSICP strategies, this research provided information concerning overall experiences and perspectives of WSICP implementation and integrated care generally.MethodsWe administered 125 in-depth interviews in two rounds over 12 months with 83 participants including patients and their carers, care facilitators, hospital specialists and nurses, allied health professionals, general practitioners and primary care nurses, and program managers. Half of the participants (n=42) were interviewed twice. We conducted an inductive, thematic analysis on the interview transcripts.ResultsKey themes related to the set-up and operationalising of WSICP; challenges encountered; and the added value of the program. Implementing WSICP was a large and time consuming undertaking but challenges including those with staffing and information technology were being addressed. The WSICP was considered valuable in reducing hospital admissions due to improved patient self-management and a focus on prevention, greater communication and collaboration between healthcare providers across health sectors and an increased capacity to manage chronic illness in the primary care setting.Conclusions Patients, carers and health providers experienced the WSICP as an innovative integrated care model and valued its patient-centred approach which was perceived to improve access to care, increase patient self-management and illness prevention, and reduce hospital admissions. Long-term sustainability of the WSICP will depend on retaining key staff, more effectively sharing information including across health sectors to support enhanced collaboration, and expanding the suite of activities into other illness areas and locations. Enhanced support for general practices to manage chronic illness in the community, in collaboration with hospital specialists is critical. Timely evaluation informs ongoing program implementation.
Social, economic, and legislative factors and global road traffic fatalities
Authors: Haghighi Mohammad Reza Rahmanian , Sayari Mohammad , Ghahramani Sulmaz , Lankarani Kamran Bagheri 
Published: August 2020

Abstract
Abstract
Background: Road traffic fatalities (RTF) is the 8th cause of mortality around the world. At the end of the Decade of Action, it would be of utmost importance to revisit our knowledge on the determinants of RTF. The aim of this study is to assess factors related to RTF at global level.
Methods: We used road safety development index which accounts for the interactions between system, human and products to assess the RTF in 115 and 113 countries in 2013 and 2016, respectively. To analyze data, three statistical procedures (linear regression, classification and regression trees, and multivariate adaptive regression splines) were employed.
Results: Classification and regression trees has the best performance amongst all others followed by multivariate adaptive regression splines for 2013 and 2016 data set with an R2 around 0.83. Results show that any increase in human development index was associated with RTF reduction. Comparing RTF data of 2013 and 2016, 8 countries experienced a change of more than 30%, which demonstrated a significant relationship with GINI index (named after Corrado Gini). Considering the three components of human development index, it is revealed that education explained most of RTF variation in classification and regression trees model followed by income and life expectancy.
Conclusion: Policymakers should consider road collisions as a socio-economic issue. In this regard, they can make provisions to reduce RTF in the long run by focusing on enhancing the three components of human development index, mainly education. However, there is a need to investigate the causation pathway among these three components with RTF with different time-trend procedures.
Effect of a free healthy school meal on fruit, vegetables and unhealthy snacks intake in Norwegian 10- to 12-year-old children
Authors: Vik Frøydis Nordgård , Heslien Kaia Elisabeth Paulsen , Lippevelde Wendy Van , Øverby Nina Cecilie 
Published: August 2020

Abstract
Background: Norwegian children have a lower intake of fruit, vegetables, and a higher intake of unhealthy snacks compared to dietary guidelines. Such dietary inadequacies may be detrimental for their current and future health. Schools are favorable settings to establish healthy eating practices. Still, no school meal arrangement is provided in Norway, and most children typically bring packed lunches from home. The aim of this study was to investigate whether serving a free healthy school meal for one year resulted in a higher intake of fruit and vegetables and a lower intake of unhealthy snacks in total among 10-12-year-olds in Norway.Methods: The School Meal Project in Southern Norway was a non-randomized trial in two elementary schools in rural areas in the school year 2014/2015. The study sample consisted of 10- to 12-year-old children; an intervention group (N=55) and a control group (N=109) resulting in a total of 164 school children at baseline. A food frequency questionnaire was completed by the children at baseline, at five months follow-up and after one year to assess fruit, vegetable and snacks intake. Multiple linear regression analyses were performed to assess intervention effects on overall intake of fruit and vegetables and unhealthy snacks.Results: Serving of a free healthy school meal for one year was associated with a higher weekly intake of vegetables on sandwiches in the intervention group compared to the control group, adjusted for baseline intake (B: 1.11 (95% CI: .38, 1.85)) at the end of the intervention. No other significant intervention effects were found for the remaining fruit and vegetables measures. Serving of a free healthy school meal was not associated with a lower weekly intake of unhealthy snacks (i.e. potato chips, candy, sugar sweetened beverages) in the intervention group compared to the control group. Conclusions: A free healthy school meal was associated with a higher weekly intake of vegetables on sandwiches but did not significantly change any other investigated dietary behaviors. However, given the inadequate intake of vegetables among children and that even moderate improvements have public health relevance, a free healthy school meal for all school children could be beneficial. Trial registration: ISRCTN61703361 Date of registration: December 3rd, 2018 Retrospectively registered
What Are the Potential Advantages and Disadvantages of Merging Health Insurance Funds? A Qualitative Policy Analysis from Iran
Authors: Bazyar Mohammad , Yazdi-Feyzabadi Vahid , Rahimi Nouroddin , Rashidian Arash 
Published: August 2020

Abstract
Background:In countries with health insurance systems, the number and size of insurance funds along with the amount of risk distribution among them are a major concern. One possible solution to overcome problems resulting from fragmentation is to combine risk pools to create a single pool. This study aimed to investigate the potential advantages and disadvantages of merging health insurance funds in Iran. Methods:In this qualitative study, a purposeful sampling with maximum variation was used to obtain representativeness and rich data. To this end, sixty-seven face-to-face interviews were conducted. Moreover, a documentary review was used as a supplementary source of data collection. Content analysis using the 'framework method' was used to analyze the data. Four trustworthiness criteria, including credibility, transferability, dependability, and confirmability, were used to assure the quality of results. Results:The potential consequences were grouped into seven categories, including stewardship, financing, population, benefit package, structure, operational procedures, and interaction with providers. According to the interviewees, controlling total health care expenditures; improving strategic purchasing; removing duplication in population coverage; centralizing the profile of providers in a single database; controlling the volume of provided health care services; making hospitals interact with single insurance with a single set of instructions for contracting, claiming review, and reimbursement; and reducing administrative costs were among the main benefits of merging health insurance funds. The interviewees enumerated the following drawbacks as well: the social security organization’s unwillingness to collect insurance premiums from private workers actively as before; increased dissatisfaction among population groups enjoying a generous basic benefits package; risk of financial fraud and corruption due to gathering all premiums in a single bank; and risk of putting more financial pressure on providers in case of delay in reimbursement with a single-payer system. Conclusion:Merging health insurance schemes in Iran is influenced by a wide range of potential merits and drawbacks. Thus, to facilitate the process and lessen opponents’ objection, policy makers should act as brokers by taking into account contextual factors and adopting tailored policies to respectively maximize and minimize the potential benefits and drawbacks of consolidation in Iran.
Elevated Blood Urea Nitrogen are associated with Recurrence of post-operative Chronic Subdural Hematoma
Authors: Wang Ning , Hu Jiangnan , Oppong-Gyebi Anthony , Zhu Xuanhao , Li Yihao , Yang Jianjing , Ruan Linhui , Zhuge Qichuan , Ye Sheng 
Published: August 2020

Abstract
Background: Chronic subdural hematoma (CSDH) is fundamentally treatable with about 2-31% recurrence rate. Recently, there has been renewed interest in the association between Blood Urea Nitrogen (BUN) and intracranial lesion. Therefore, this paper attempts to show the relationship between BUN and CSDH recurrence.Methods: A total of 653 CSDH cases with Burr-hole Irrigation (BHI) were enrolled from December 2014 to April 2019. The analyzed parameters included age, gender, comorbidities, laboratory investigations, medication use and hematoma location. The cases were divided into recurrence and non-recurrence groups while postoperative BUN concentration was further separated into quartiles (Q1 ≤ 4.0 mmol/L, 4.0 < Q2 ≤ 4.9 mmol/L, 4.9 < Q2 ≤ 6.4 mmol/L, Q4 > 6.4 mmol/L). Restricted cubic spline regressions and logistic regression models were performed to estimate the effect of BUN on CSDH recurrence.Results: CSDH recurrence was observed in 96 (14.7%) cases. Significant distinctions were found between recurrence and non-recurrence groups in postoperative BUN quartiles of cases (P=0.003). After adjusting for the potential confounders, the odds ratio of recurrence was 3.069 (95%CI =1.488–6.330, p = 0.002) for the highest quartile of BUN compared with the lowest quartile. In multiple-adjusted spline regression, high BUN level visually showed significantly high OR value of recurrence risk.Conclusions: Elevated BUN at post-operation is significantly associated with the recurrence of CSDH, and it is indicated that high levels of serum BUN after evacuation may be served as a risk factor for CSDH recurrence.
Comparison of Conventional Fenestration Discectomy with Transforaminal Endoscopic Lumbar Discectomy for Treating Lumbar Disc Herniation：Minimum 2-year Long-term Follow-up in 1,100 patients
Authors: Li Quanyi , zhou yongchun 
Published: August 2020

Abstract
Purpose: To compare the efficacy of conventional interlaminar fenestration discectomy (IFD) with transforaminal endoscopic lumbar discectomy (TELD) for treating lumbar disc herniation (LDH). Methods: The clinical data of 1,100 patients who had been diagnosed with LDH between January 2012 and December 2017 were retrospectively analysed. IFD was performed on 605 patients in Group A, whereas TELD was performed on 505 patients in Group B. The Oswestry Disability Index, Visual Analogue Scale for pain and modified MacNab criteria were used to evaluate the outcomes. The surgery duration, intraoperative blood loss, postoperative off-bed activity and postoperative length of hospital stay were recorded. Results: The follow-up period ranged from 24 to 60 months, with an average of 43 months. The excellent and good outcome rates were 93.5% in Group A and 92.6% in Group B. There was no significant difference in efficacy between the groups (P > 0.05). However, Group B had significantly less intraoperative blood loss and shorter bed rest duration and postoperative length of hospital stay than Group A (P < 0.05). There were two cases of postoperative recurrence in Group A and three in Group B. Conclusions: Although conventional IFD and TELD had similar levels of efficacy in treating LDH, TELD had several advantages. There was less intraoperative bleeding, shorter length of hospital stay and shorter bed rest duration. It can be considered a safe and effective surgical option for treating LDH.
What Matters to Patients? A Mixed Method Study of the Importance and Consideration of Patient Demands
Authors: Waelli Mathias , Minvielle Etienne , Acero Maria Ximena , Aribi Khouloud Ben , Lalloue Benoit 
Published: August 2020

Abstract
BackgroundA patient-centred approach is increasingly the mandate for healthcare delivery, especially with the growing emergence of chronic conditions. A relevant but often overlooked obstacle to delivering person-centred care is the identification and consideration of all demands based on individual experience, not only disease-based requirements. Mindful of this approach, there is a need to explore how patient demands are expressed and considered in healthcare delivery systems.This study aims to: (i) understand how different types of demands expressed by patients are taken into account in the current delivery systems operated by Health Care Organisations (HCOs); (ii) explore the often overlooked content of specific non-clinical demands (i.e. demands related to interactions between disease treatments and everyday life).MethodWe adopted a mixed method in two cancer centres, representing exemplary cases of organisational transformation: (i) circulation of a questionnaire to assess the importance that patients attach to every clinical (C) and non-clinical (NC) demand identified in an exploratory inquiry, and the extent to which each demand has been taken into account based on individual experiences; (ii) a qualitative analysis based on semi-structured interviews exploring the content of specific NC demands.ResultsFurther to the way in which the questionnaires were answered (573 answers/680 questionnaires printed) and the semi-structured interviews (36) with cancer patients, results show that NC demands are deemed by patients to be almost as important as C demands (C = 6.53/7 VS. NC = 6.13), but are perceived to be considered to less of an extent in terms of pathway management (NC = 4.02 VS C = 5.65), with a significant variation depending on the type of non-clinical demands expressed. Five types of NC demands can be identified: demands relating to daily life, alternative medicine, structure of the treatment pathway, administrative and logistic assistance and demands relating to new technologies.ConclusionsThis study shows that HCOs should be able to consider non-clinical demands in addition to those referring to clinical needs. These demands require revision of the healthcare professionals’ mandate and transition from a supply-orientated system towards a demand-driven approach throughout the care pathway. Other sectors have developed hospitality management, mass customisation and personalisation to scale up approaches that could serve as inspiring examples.
Mathematical models for devising the optimal SARS-CoV-2 strategy for eradication in China, South Korea, and Italy
Authors: Jiang Shuo , Li Qiuyue , Li Chaoqun , Liu Shanshan , He Xiaomeng , Wang Tao , Li Hua , Corpe Christopher , Zhang Xiaoyan , Xu Jianqing , Wang Jin 
Published: August 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.Methods: To improve the forecast accuracy and investigate the spread of SARS-CoV-2, we constructed four mathematical models to numerically estimate the spread of SARS-CoV-2 and the efficacy of eradication strategies.Results: Using the Susceptible-Exposed-Infected-Removed (SEIR) model, and including measures such as city closures and extended leave policies implemented by the Chinese government that effectively reduced the β value, we estimated that the β value and basic transmission number, R0, of SARS-CoV-2 was 0.476/6.66 in Wuhan, 0.359/5.03 in Korea, and 0.400/5.60 in Italy. Considering medicine and vaccines, an advanced model demonstrated that the emergence of vaccines would greatly slow the spread of the virus. Our model predicted that 100,000 people would become infected assuming that the isolation rate α in Wuhan was 0.30. If quarantine measures were taken from March 10, 2020, and the quarantine rate of α was also 0.3, then the final number of infected people was predicted to be 11,426 in South Korea and 147,142 in Italy.Conclusions: Our mathematical models indicate that SARS-CoV-2 eradication depends on systematic planning, effective hospital isolation, and SARS-CoV-2 vaccination, and some measures including city closures and leave policies should be implemented to ensure SARS-CoV-2 eradication.