bluuebunny/crossref_metadata_2025_split huggingface dataset:
General practitioners’ management of patients with psychological stress: audit results from Denmark
Authors: Lykkegaard Jesper , Prior Anders , Rosendal Marianne 
Published: December 2019

Abstract
Background: In western countries, psychological stress is among the most common causes of long-lasting sick leave and a frequent reason to consult the general practitioner (GP). Aims: This study aimed to investigate how GPs manage patients with psychological stress and how the management is associated with the patient´s sex, the GP’s assessment of causality, and coexisting mental disorders. Design and setting: Audit of consecutive cases in Danish general practice. Methods: The GPs used electronic medical records to fill in a registration form for each 18-65-year-old patient with whom they had had at least one consultation regarding stress during the past six months. Only patients initially on the labour market were included. Results: Fifty-six GPs (61% women) identified 785 cases. The patients’ mean age was 44 years and 69% were women. The cause of stress was considered at least partially work-related in 69% of the cases and multifactorial in a third of cases. The management included sick leave (54%), talk therapy by the GP (47%), pharmaceutical treatment (37%), and referral to a psychologist (38%). Compared to women, stress in men was less often considered work-related (RR: 0.84, CI95%: 0.77-0.92) and men were less often sick-listed (RR: 0.83 CI95%: 0.73-0.96) but were more often prescribed tranquilizers (RR: 1.72 CI95%: 1.08-2.74). Conclusions: GPs’ management of patients with stress usually involve elements of talk-therapy, sick leave, referral to psychologist, and medication. Women and men with stress are perceived of and managed differently.
The effect of a centralization procedure for extruded lateral meniscus on load distribution in porcine knee joints at different flexion angles
Authors: Kubota Rei , Koga Hideyuki , Ozeki Nobutake , Matsuda Junpei , Kohno Yuji , Mizuno Mitsuru , Hisako Hisako , Sekiya Ichiro 
Published: December 2019

Abstract
Background: Meniscal extrusion results in loss of the ability to resist hoop strain and biomechanical overload on the joint articular surface. A centralization technique has been developed to overcome these problems. In this study, we analyzed the biomechanics of the extruded and centralized lateral meniscus (LM) in porcine knee joints at different flexion angles. Methods: Porcine knee joints (n=8) were set in the universal tester and each knee was tested under the following states: 1) intact; 2) extrusion—meniscal extrusion was created by resecting the posterior root of the LM and posterior synovial capsule; and 3) centralization—centralization was performed by two anchors inserted in the lateral tibial plateau. Deviation distance of the meniscus, contact pressure, and contact area in the anterior LM, middle LM, posterior LM, and the contact pressure of the tibial cartilage were evaluated with an axial compressive force of 200 N at knee flexion angles of 30°, 45°, 60°, and 90°. Results: The deviation distance of LM significantly increased in extrusion but was restored to the intact status after centralization at all angles. Both the contact pressure and area significantly decreased in extrusion and were restored after centralization close to the intact status in the anterior and middle LM; in the posterior LM, however, decreased contact pressure and area were not restored after centralization. The contact pressure of the tibial cartilage increased significantly in extrusion but decreased close to the intact status after centralization. Conclusions: This centralization procedure could reduce extrusion of the LM and restore the load-distributing function of the anterior-middle LM. However, the procedure itself could not restore hoop function in cases where the defect lies in the posterior LM.
Trends in Measles Cases in Bayelsa State, Nigeria: A Five-year Review of Case-based Surveillance Data (2014- 2018).
Authors: AWORABHI NENI , Numbere Tamunowari , Balogun Mohammed Shakir , Usman Aisha , Utulu Rowland , Ebere Nkechi , Omubo Wakiente , Stow Jones , Abba Shehu , Olorukooba Abdulhakim 
Published: December 2019

Abstract
Measles is a vaccine preventable, highly transmissible viral infection that affects mostly children under five years. It has been ear marked for eradication and Nigeria adopted the measles elimination strategies of the World Health Organization (WHO) African region to reduce cases and deaths. This study was done to determine trends in measles cases in Bayelsa State, to describe cases in terms of person and place, identify gaps in the case-based surveillance data collection system and identify risk factors for measles infection. We carried out a secondary data analysis of measles case-based surveillance data for the period of January 2014 to December 2018 obtained in Microsoft Excel from the State Ministry of Health. Cases were defined according the World Health Organization (WHO) standard case definitions. We calculated frequencies, proportions, estimated odds ratios (OR), 95% confidence intervals (CI) and multivariate analysis. A total of 449 cases of measles were reported. There were 245(54.6%) males, the most affected age group was 1-4 years with 288(64.1%) cases. Of all cases, 289(9.35%) were confirmed and 70 (48.27%) had received at least one dose of measles vaccine. There was an all-year transmission with increased cases in the 4th quarter of the year. Yenegoa Local Government Area had the highest number of cases. Timeliness of specimen reaching the laboratory and the proportion of specimens received at the laboratory with results sent to the national level timely was below WHO recommended 80%. Predictors of measles infection were, age less than 5 years (AOR: 0.57, 95% CI: 0.36-0.91) and residing in an urban area (AOR: 1.55, 95% CI:1.02-2.34). Measles infection occurred all-year round, with children less than 5 years being more affected. Measles case-based surveillance system showed high levels of case investigation with poor data quality and poor but improving indicators. Being less than 5 years was protective of measles while living in urban areas increased risk for infection. We recommended to state government to prioritize immunization activities in the urban centers, start campaigns by 4th quarter and continue to support measles surveillance activities while the federal government to strengthen regional laboratory capacities. Measles, Surveillance, Vaccination, Nigeria, Trend, Predictors
Rural Chronic Disease Research Patterns In The United Kingdom, United States, Canada, Australia And New Zealand: A Systematic Integrative Review
Authors: Disler Rebecca , Glenister Kristen , Wright Julian 
Published: December 2019

Abstract
Background People living in rural and remote communities commonly experience significant health disadvantages. Geographical barriers and reduced specialist and generalist services impact access to care when compared with metropolitan context. Innovative models of care have been developed for people living with chronic diseases in rural areas with the goal of overcoming these inequities. This review aims to describe the state of knowledge regarding innovative models of care and clinical outcomes for people living with chronic disease in rural areas in developed countries where a metropolitan comparator is included. Methods An integrative systematic review was undertaken. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method was used to understand data on clinical outcomes for people living with chronic disease in rural compared with metropolitan contexts and their models of care in Australia, New Zealand, United States, Canada and the United Kingdom Results Literature searching revealed 620 articles published in English between 1st January 2000 and 31st March 2019. 160 were included in the review including 68 from the United States, 59 from Australia and New Zealand (5), 21 from Canada and 11 from the United Kingdom and Ireland. 53% (84) focused on cardiovascular disease; 27% (43) diabetes mellitus; 8% (12) chronic obstructive pulmonary disease; and 13% (27) chronic kidney disease. Mortality was only reported in 10% (16) of studies and only 18% (29) reported data on Indigenous populations. Conclusions This integrated review reveals that the published literature on common chronic health issues pertaining to rural and remote populations is largely descriptive. Only a small number of publications focus on mortality and comparative health outcomes from health care models in both urban and non-urban populations. Innovative service models and telehealth are together well represented in the published literature but data on health outcomes is relatively sparse. There is significant scope for further directly comparative studies detailing the effect of service delivery models on the health outcomes of urban and rural populations. We believe that such data would further knowledge in this field and help to break the deadly synergy between increased rurality and poorer outcomes for people with chronic disease.
Classification of Andrographis paniculata extracts by HPLC fingerprint analysis and chemometrics
Authors: Rafi Mohamad , Devi Anggun Fenika , Syafitri Utami Dyah , Heryanto Rudi , Suparto Irma Herawati , Amran Muhammad Bachri , Rohman Abdul , Prajogo Bambang , Lim Lee Wah 
Published: December 2019

Abstract
Objective: Andrographis paniculata is widely used in Indonesia traditional medicines called jamu as an antidiabetic. The concentration of some chemical compound will be related to the level of therapeutic effect of A. paniculata and the solvent concentration for extraction affects the number of extracted chemical compound. Quality control method is needed to ensure the consistency level of chemical compound in A. paniculata. High-performance liquid chromatography fingerprint analysis combined with chemometrics was used for evaluation of sambiloto extract according to different solvent extraction. In addition, determination of the andrographolide (major bioactive compound in A. paniculata) and α-glucosidase inhibition activity were also performed. Result: Fingerprint chromatogram of A. paniculata extract with different solvent concentration have similar pattern with several typical peaks appear on each extract, only differ in the peak area and intensity value. Classification of each A. paniculata extract was done by using HPLC fingerprint and principal component analysis. Based on this classification, each extract is grouped in to their respective solvent extraction. The highest andrographolide content and α-glucosidase inhibition activity were in 50% ethanol extract and the lowest were in the water extract. HPLC fingerprint analysis could be used for identification of A. paniculata extract based on solvent extraction.
Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review
Authors: Rabiei Morteza , Kashanian Soheila , Samavati Seyedeh S. , Jamasb Shahriar , McInnes Steven J.P. 
Published: December 2019

Background:
Treatment of neurological diseases using systemic and non-surgical techniques
presents a significant challenge in medicine. This challenge is chiefly associated with the condensation
and coherence of the brain tissue.

Methods:
The coherence structure of the brain is due to the presence of the blood-brain barrier (BBB),
which consists of a continuous layer of capillary endothelial cells. The BBB prevents most drugs from
entering the brain tissue and is highly selective, permitting only metabolic substances and nutrients to
pass through.

Results:
Although this challenge has caused difficulties for the treatment of neurological diseases, it
has opened up a broad research area in the field of drug delivery. Through the utilization of nanoparticles
(NPs), nanotechnology can provide the ideal condition for passing through the BBB.

Conclusion:
NPs with suitable dimensions and optimum hydrophobicity and charge, as well as appropriate
functionalization, can accumulate in the brain. Furthermore, NPs can facilitate the targeted delivery
of therapeutics into the brain areas involved in Alzheimer’s disease, Parkinson’s disease, stroke,
glioma, migraine, and other neurological disorders. This review describes these methods of actively
targeting specific areas of the brain.
Identification of Differentially Expressed Hematopoiesis-associated Genes in Term Low Birth Weight Newborns by Systems Genomics Approach
Authors: Singh Sakshi , Singh Vinay K. , Rai Geeta 
Published: December 2019

Background:
Low Birth Weight (LBW) (birth weight <2.5 Kg) newborns are associated
with a high risk of infection, morbidity and mortality during their perinatal period. Compromised innate
immune responses and inefficient hematopoietic differentiation in term LBW newborns led us to
evaluate the gene expression status of hematopoiesis.

Materials and Methods:
In this study, we compared our microarray datasets of LBW-Normal Birth
Weight (NBW) newborns with two reference datasets to identify hematopoietic stem cells genes, and
their differential expression in the LBW newborns, by hierarchical clustering algorithm using gplots
and RcolorBrewer package in R.

Results:
Comparative analysis revealed 108 differentially expressed hematopoiesis genes (DEHGs),
of which 79 genes were up-regulated, and 29 genes were down-regulated in LBW newborns compared
to their NBW counterparts. Moreover, protein-protein interactions, functional annotation and pathway
analysis demonstrated that the up-regulated genes were mainly involved in cell proliferation and differentiation,
MAPK signaling and Rho GTPases signaling, and the down-regulated genes were engaged
in cell proliferation and regulation, immune system regulation, hematopoietic cell lineage and
JAK-STAT pathway. The binding of down-regulated genes (LYZ and GBP1) with growth factor GMCSF
using docking and MD simulation techniques, indicated that GM-CSF has the potential to alleviate
the repressed hematopoiesis in the term LBW newborns.

Conclusion:
Our study revealed that DEHGs belonged to erythroid and myeloid-specific lineages and
may serve as potential targets for improving hematopoiesis in term LBW newborns to help build up
their weak immune defense against life-threatening infections.
Motivasi dan tanggung jawab siswa dalam pembelajaran berbasis proyek, sebuah penelitian tindakan kelas
Authors: Susetyarini Rr. Eko , Permana Tutut Indria , Gunarta Gunarta , Setyawan Dwi , Latifa Roimil , Zaenab Siti 
Published: December 2019

Perkembangan teknologi di era revolusi industri 4.0 memberikan tantangan kepada siswa agar mampu menghadapi berbagai macam situasi. Siswa sebagai generasi muda yang akan hidup di era tersebut harus memiliki motivasi belajar dan rasa tanggung jawab yang tinggi. Motivasi siswa akan muncul ketika mereka dihadapkan pada tugas proyek yang harus diselesaikan dalam waktu tertentu, sama halnya dengan rasa tanggung jawab mereka. Oleh karena itu penelitian ini bertujuan untuk mendiskripsikan bagaimana pembelajaran berbasis proyek dapat meningkatkan motivasi dan rasa tanggung jawab siswa. Penelitian deskriptif kualitatif ini menggunakan 34 siswa Sekolah Menengah Atas (SMA) sebagai subjek penelitian. Motivasi dan rasa tanggung jawab siswa diukur dengan menggunakan lembar observasi dan kuesioner. Hasil penelitian menunjukkan bahwa ada peningkatan motivasi dan rasa tanggung jawab siswa setelah implementasi pembelajaran berbasis proyek. Students’ motivation and responsibility in project-based learning, a classroom action research AbstractTechnological developments in the industrial revolution era 4.0 provide a challenge for students to be able to face a variety of situations. Student, as gold generation, must have the motivation to learn and a high sense of responsibility. Motivation of students will emerge when they are faced with project tasks that must be completed in a certain time, as well as their sense of responsibility. Therefore this study aims to describe how project-based learning can improve students' motivation and sense of responsibility. This qualitative descriptive study uses 34 senior high school students as the research subjects. Motivation and students' responsibility is measured using an observation sheet and questionnaire. The results showed that there was an improvement in students' motivation and sense of responsibility after the implementation of project-based learning.
Application rasch model using R program in analyze the characteristics of chemical items
Authors: Purnamasari Untung Desy , Kartowagiran Badrun 
Published: December 2019

Chemistry is one of the subjects taught in high school. To find out and assess students' understanding regarding chemistry subjects in one semester can be proven by a test. The tests used must have good quality. This study aims to provide information about the characteristics of chemical items test using the Rasch model. Descriptive explorative was used in this study. The subject of the study were tenth grade students in Xaverius Senior High School taken the final semester examination on chemistry subject. The object of this research were the form of item tests and student answer sheets. Data collection techniques used documentation. Student answer sheets were analyzed using the R program. The results showed that the reliability of the item tests was 0.3 to 0.54 or medium category. Subsequently acquired a good level of difficulty about which amounted to 28 items. In addition, the average student ability is 0.008 with a minimum ability of -2.309 and a maximum of 2.233. ICC and IIC obtained are very accurate in predicting students' abilities. Chemicals items used in the final semester examination can be used by teachers as a item bank for use in the evaluation of students' abilities. However, there are two items that need to be revised level of difficulty to produce a good question.
Metas do Conselho Nacional de Justiça 2012/2013: uma análise dos contornos gerenciais assumidos pela reforma do Poder Judiciário no Brasil
Authors: Sena Gabriel Astoni 
Published: December 2019

Este artigo tem como objetivo avançar no estudo do processo de reforma do Poder Judiciário brasileiro, o qual se insere no processo de reforma do Estado pátrio. A partir das contribuições de Osborne e Gaebler (1992) e Abrucio (2006), buscou-se traçar um paralelo entre as lógicas gerencial e fiscal e esclarecer como as mesmas refletiram nos indicadores de eficácia, eficiência e efetividade do Poder Judiciário no Brasil. Para atingir o objetivo proposto, optou-se por utilizar como método a análise de conteúdo de Bardin (2002), pela regra de enumeração do tipo frequência, buscando, com isso, observar o papel que o Conselho Nacional de Justiça exerceu nesse processo e a lógica do plano de metas estabelecido pela instituição para os anos de 2012 e 2013. Como resultado, observou-se que as metas estabelecidas para o biênio buscaram implantar uma gestão mais eficaz nesse núcleo estratégico do Estado, com ênfase na celeridade processual, gestão administrativa e informatização dos procedimentos. Percebeu-se que a lógica gerencial continua exercendo grande influência no modelo de gestão adotado. Como novidade, verificou-se a inserção de indicadores de efetividade, os quais podem permitir aproximar os objetivos dessa esfera de poder com os da sociedade brasileira, repercutindo na elaboração de metas futuras.Palavras-chave: poder judiciário, reforma judiciária, administração pública, eficiência, eficácia.
Comprometimento no trabalho de gestores públicos em uma autarquia estadual no Brasil
Authors: Nascimento Aparecida Lourdes do , Emmendoerfer Magnus , Gava Rodrigo 
Published: December 2019

O objetivo deste artigo é compreender a percepção dos gestores, que atuam com o planejamento estratégico de uma organização pública, sobre o construto de comprometimento no trabalho, bem como a influência dessa percepção em suas práticas cotidianas de gestão. Para tanto, realizou-se, inicialmente, pesquisa bibliográfica focando questões relacionadas ao sentido e natureza do construto, bem como sobre os estudos realizados sobre o tema do comprometimento no contexto da administração pública. Em seguida, foram coletados dados com gestores mediante entrevista com roteiro semiestruturado, os quais foram analisados por meio da técnica de análise de conteúdo. As evidências indicam que os gestores associam o vínculo ao trabalho a questões atitudinais e de intenções comportamentais e que suas práticas cotidianas são influenciadas pela percepção de comprometimento dos indivíduos, admitindo que as decisões tomadas, motivadas por essa percepção, podem trazer consequências negativas tanto para a organização quanto para o indivíduo.Palavras-chave: comprometimento organizacional, agente público, administração pública, burocracia, estudo de caso
Pendayagunaan Zakat Mal dalam Mengentaskan Kemiskinan (Study kasus Mustahiq kelurahan Batua kecamatan Manggala kota Makassar)
Authors: Syarifudin Syarifudin 
Published: December 2019

<p>This study aims to determine the use of zakat mal (productive and commercial) influence on poverty alleviation in Kelurahan Batua, Manggala District, Makassar City.</p><p>The research method used is descriptive quantitative research methods with econometric and Syar'i approaches. The sample used in this study were 100 respondents and this data was analyzed using chi-square test analysis and crostab analysis. </p><p>The results of the chi-square test results show that 0,000 is greater than the significance level of α = 0.05, this shows that there is an effect of productive and com- mercial zakat utilization on poverty alleviation. The value of P (Risk) is 13.167%, this means that mustahiq which utilizes its zakat on target is likely to increase its welfare by 13.167%. Suggestions for BAZNAS of South Sulawesi Province should focus the program on one area that is favored to alleviate poverty through the empowerment of the community's economy so that the visible results of the utilization of zakat funds are visible.</p><p><strong><em>Keywords: Utilization, Zakat Mal, Proverty</em></strong></p>