bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Evolution of Human Cancer Gene Duplications across Mammals
Authors: Tollis Marc , Schneider-Utaka Aika K. , Maley Carlo C. 
Published: March 2020

AbstractCancer is caused by genetic alterations that affect cellular fitness, and multicellular organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints and apoptosis. These pathways may be enhanced by the addition of tumor suppressor gene paralogs or deletion of oncogenes. To provide insights to the evolution of cancer suppression across the mammalian radiation, we estimated copy numbers for 548 human tumor suppressor gene and oncogene homologs in 63 mammalian genome assemblies. The naked mole rat contained the most cancer gene copies, consistent with the extremely low rates of cancer found in this species. We found a positive correlation between a species’ cancer gene copy number and it’s longevity, but not body size, contrary to predictions from Peto’s Paradox. Extremely long-lived mammals also contained more copies of caretaker genes in their genomes, suggesting that the maintenance of genome integrity is an essential form of cancer prevention in long-lived species. We found the strongest association between longevity and copy numbers of genes that are both germline and somatic tumor suppressor genes, suggesting selection has acted to suppress both hereditary and sporadic cancers. We also found a strong relationship between the number of tumor suppressor genes and the number of oncogenes in mammalian genomes, suggesting complex regulatory networks mediate the balance between cell proliferation and checks on tumor progression. This study is the first to investigate cancer gene expansions across the mammalian radiation and provides a springboard for potential human therapies based on evolutionary medicine.
Fronto-striatal projections regulate approach-avoidance conflict
Authors: Loewke Adrienne C. , Minerva Adelaide R. , Nelson Alexandra B. , Kreitzer Anatol C. , Gunaydin Lisa A. 
Published: March 2020

ABSTRACTThe dorsomedial prefrontal cortex (dmPFC) has been linked to approach-avoidance behavior and decision-making under conflict, key neural computations thought to be altered in anxiety disorders. However, the heterogeneity of efferent prefrontal projections has obscured identification of the specific top-down neural pathways regulating these anxiety-related behaviors. While the dmPFC-amygdala circuit has long been implicated in controlling reflexive fear responses, recent work suggests that this circuit is less important for avoidance behavior. We hypothesized that dmPFC neurons projecting to the dorsomedial striatum (DMS) represent a subset of prefrontal neurons that robustly encode and drive approach-avoidance behavior. Using fiber photometry recording during the elevated zero maze (EZM) task, we show heightened neural activity in prefrontal and fronto-striatal projection neurons, but not fronto-amydalar projection neurons, during exploration of the anxiogenic open arms of the maze. Additionally, through pathway-specific optogenetics we demonstrate that this fronto-striatal projection preferentially excites postsynaptic D1 receptor-expressing medium spiny neurons in the DMS and bidirectionally controls avoidance behavior. We conclude that this striatal-projecting subpopulation of prefrontal neurons regulates approach-avoidance conflict, supporting a model for prefrontal control of defensive behavior in which the dmPFC-amygdala projection controls reflexive fear behavior and the dmPFC-striatum projection controls anxious avoidance behavior. Our findings identify this fronto-striatal circuit as a valuable therapeutic target for developing interventions to alleviate excessive avoidance behavior in anxiety disorders.
Effects of transcranial direct current stimulation on brain networks related to creative thinking
Authors: Koizumi Koji , Ueda Kazutaka , Li Ziyang , Nakao Masayuki 
Published: March 2020

AbstractHuman creative thinking is unique and capable of generating novel and valuable ideas. Recent research has clarified the contribution of different brain networks (default mode network, DN; executive control network; salience network) to creative thinking. However, the effects of brain stimulation on brain networks during creative thinking and on creative performance have not been clarified. The present study was designed to examine the changes in functional connectivity (FC) and effective connectivity (EC) of the large-scale brain network, and the ensuing changes in creative performance, induced by transcranial direct current stimulation (tDCS). Fourteen healthy male students underwent two tDCS sessions, one with actual stimulation and one with sham stimulation, on two separate days. Participants underwent tDCS (anode over the left dorsolateral prefrontal cortex, DLPFC; cathode over the right inferior parietal lobule, IPL) for 20 minutes. Before and after the tDCS session, electroencephalography signals were acquired from 32 electrodes over the whole head during the creative thinking task. On FC analysis, the delta band FC between the posterior cingulate cortex and IPL significantly increased only after real stimulation. We also found that the change of flexibility score was significantly correlated with the change in (i) delta band FC between mPFC and left lateral temporal cortex (LTC) and (ii) alpha band FC between IPL and right LTC. On EC analysis, decreased flow within the DN (from left LTC to right IPL) was observed. Our results reveal that tDCS could affect brain networks, particularly the DN, during creative thinking and modulate key FC in the generation of flexible creative ideas.
Art marketing as an emerging area in an emerging market
Authors: Gürşen Aylin Ecem 
Published: March 2020

PurposeIn this study, art is considered as a product subjected to marketing activities. In this context, this study aims to present a conceptual framework covering the research areas related to art marketing, the relation of art product with brand and consumer and how internet technologies can transform the art market. Finally, the situation of art marketing and its progressing process in a developing country and its potential horizons was discussed.Design/methodology/approachThis study uses a literature review to present a conceptual framework about art marketing activities and their potential horizons in an emerging country.FindingsGlobalization, digitalization, democratization of access to art products, art becoming a subject for marketing, open up new horizons for western markets as well as for developing countries. Developing countries constitute a new market segment for the art market. Addressing the changes and the transformations in art market in terms of these markets will provide important opportunities for marketing researchers and practitioners.Originality/valueThis study elaborates the art marketing concept in a developing country. The marketing of art is a subject studied and elaborated mostly in western countries. It is thought that this study is differentiated in terms of addressing these dynamics from a developing country point of view.
Through the lens of choreographic process
Authors: deLahunta Scott , Vincent Jordan Beth 
Published: March 2020

PurposeThis article aims to bring together and demonstrate overlaps in three different areas of reflexive research concerned variously with audiences for contemporary dance. These are: 1) artists reflecting on their own creative process and engaging other researchers in doing so, generating new insights and language as a result; 2) humanities-based dance studies and a small number of dance scholars reflecting on this “process turn” in dance; and 3) the field of empirical audience studies, drawing on a single study specifically interested in access to creative process. The goal is to propose how these areas might coexist and mutually inform each other.Design/methodology/approachThe approach develops a three-fold framework where the multiple definitions and examples of reflexive research in dance-making processes coexist. It draws systematically on a detailed example of one self-reflective study conducted by a dance company into creative process, on new scholarly writing on the “process turn” in dance research and written analysis of a unique audience research project as well as related literature.FindingsIn conclusion, the article suggests that in whatever combination of different research approaches, empirical evidence is increasingly important. This risks tipping the balance towards a more utilitarian understanding, particularly in the area of audience studies. It is possible to counterbalance this with approaches from artists and scholars interested in understanding arrived at through reflexive study of creative practice.Originality/valueThe original contribution is to bring these three areas together for the first time to expose difference and overlaps and suggest that challenges of understanding (in a non-utilitarian form) could be mitigated through more systematic dialogue between them, such as presented here.
Analysis of memristor-based differentiating circuit
Authors: Kirilov Stoyan , Zaykov Ivan 
Published: March 2020

Purpose
The purpose of this paper is to propose a detailed analysis of a memristor-based differentiating circuit with buffering amplifier, a capacitor and a memristor.

Design/methodology/approach
The analyzed circuit is based on a resistor–capacitor differentiating scheme together with a buffering operational amplifier. In the proposed circuit, the resistor is replaced by a memristor element.

Findings
The considered circuit and its classical analog are investigated using a rectangular pulse sequence as input signal. A comparison between the derived results is made. An advantage of the proposed memristor circuit is the shortened duration, i.e. higher localization, of the output pulses of rectangular input pulses to be derived.

Originality/value
Differentiating circuits are important modules in radio-electronics. Because of their widespread usage, it is of higher interest that their new potential schematic realizations are analyzed. For the computer simulations, a previously proposed modified nonlinear memristor model is used. Several of the best and widely used basic memristor models are applied as well.
Free upgrades with costly consequences
Authors: Polyakova Alexandra , Estes Zachary , Ordanini Andrea 
Published: March 2020

Purpose
Companies often provide preferential treatment, such as free upgrades, to customers. The present study aims to identify a costly consequence of such preferential treatment (i.e. opportunistic behavior) and reveal which type of customer is most likely to engage in that negative behavior (i.e. new customers).

Design/methodology/approach
Across two experimental studies, the authors test whether preferential treatment increases customers’ entitlement, which in turn increases their propensity to behave opportunistically. Moderated mediation analysis further tests whether that mediated effect is moderated by customers’ prior relationship with the company.

Findings
Preferential treatment increases feelings of entitlement, which consequently triggers customers’ opportunistic behaviors. New customers are more likely to feel entitled after preferential treatment than repeat customers, and hence new customers are more likely to behave opportunistically. Preferential treatment also increases customers’ suspicion of the company’s motives, but suspicion was unrelated to opportunistic behavior.

Research limitations/implications
Future research may focus on other marketplace situations that trigger entitlement and explore whether multiple occurrences of preferential treatment provide different effects on consumers.

Practical implications
Present findings demonstrate that preferential treatment can evoke opportunistic behaviors among customers. The authors suggest that preferential treatment should be provided to customers who previously invested in their relationship with a company (i.e. repeat customers) rather than new customers.

Originality/value
Prior research has focused more on the ways companies prioritize their repeat customers than how they surprise their new customers. The present research instead examines preferential treatment based on customers’ relationship with a firm (i.e. both repeat and new customers) and demonstrates behavioral and contextual effects of entitlement.
Stress in paramedics: relationships with coping strategies and personality traits
Authors: Duschek Stefan , Bair Angela , Haux Sarah , Garrido Alba , Janka Amelie 
Published: March 2020

PurposeThough working in the ambulance service implies persistent confrontation with human suffering and exposure to significant work-related stressors, previous research revealed comparatively low self-reported stress in paramedics. This study investigated stress, personality traits, sensation seeking and resilience in paramedics. Moreover, the impact of psychological variables on individual differences in paramedics' stress burden was explored.Design/methodology/approachA convenience sample of 395 paramedics and 397 professionals from other disciplines completed the Perceived Stress Questionnaire, Stress Coping Style Questionnaire, Big Five Inventory, Sensation Seeking Scale and Resilience Scale. Multivariate group comparison and regression analysis were performed.FindingsCompared to other professionals, paramedics reported lower stress burden, more positive and less negative coping strategies, lower neuroticism and higher extraversion, conscientiousness, openness, agreeableness, adventure seeking and resilience. In the regression analysis conducted on paramedics, positive coping, resilience, extraversion and conscientiousness negatively predicted perceived stress; negative coping and neuroticism were positive predictors.Research limitations/implicationsThe cross-sectional design of the study limits the interpretability of the data.Practical implicationsTraining in stress management and resilience should be core elements in the education of paramedics.Originality/valueThe findings confirm the notion of reduced stress burden and increased resilience in paramedics. Regarding personality traits, a pattern of emotional stability, conscientiousness, extraversion, prosocial attitudes and propensity to exciting experiences might characterize this group. Moreover, the use of adaptive coping strategies, high levels of resilience, extraversion and conscientiousness and low neuroticism are associated with lower stress burden in paramedics.
The “power few” of missing persons’ cases
Authors: Huey Laura , Ferguson Lorna , Kowalski Larissa 
Published: March 2020

PurposeThe purpose of this paper is to test the “power few” concept in relation to missing persons and the locations from which they are reported missing.Design/methodology/approachData on missing persons’ cases (n = 26,835) were extracted from the record management system of a municipal Canadian police service and used to create data sets of all of the reports associated with select repeat missing adults (n = 1943) and repeat missing youth (n = 6,576). From these sources, the five locations from which repeat missing adults and youth were most commonly reported missing were identified (“power few” locations). The overall frequency of reports generated by these locations was then assessed by examining all reports of both missing and repeat missing cases, and demographic and incident factors were also examined.FindingsThis study uncovers ten addresses (five for adults; five for youths) in the City from which this data was derived that account for 45 percent of all adults and 52 percent of all youth missing person reports. Even more striking, the study data suggest that targeting these top five locations for adults and youths could reduce the volume of repeat missing cases by 71 percent for adults and 68.6 percent for youths. In relation to the demographic characteristics of the study’s sample of adults and youths who repeatedly go missing, the authors find that female youth are two-thirds more likely to go missing than male youth. Additionally, the authors find that Aboriginal adults and youths are disproportionately represented among the repeat missing. Concerning the incident factors related to going missing repeatedly, the authors find that the repeat rate for going missing is 63.2 percent and that both adults and youths go missing 3–10 times on average.Practical implicationsThe study results suggest that, just as crime concentrates in particular spaces among specific offenders, repeat missing cases also concentrate in particular spaces and among particular people. In thinking about repeat missing persons, the present research offers support for viewing these concerns as a behavior setting issue – that is, as a combination of demographic factors of individuals, as well as factors associated with particular types of places. Targeting “power few” locations for prevention efforts, as well as those most at risk within these spaces, may yield positive results.Originality/valueVery little research has been conducted on missing persons and, more specifically, on how to more effectively target police initiatives to reduce case volumes. Further, this is the first paper to successfully apply the concept of the “power few” to missing persons’ cases.
Hidden danger
Authors: Violanti John M. , Fekedulegn Desta , Shi Mingming , Andrew Michael E. 
Published: March 2020

PurposeLaw enforcement is a dangerous profession not only due to assaults, accidents and homicides but also due to health risks. This study examined trends in the national frequency and rate of law enforcement job-related illness deaths in the United States over a 22-year period (1997–2018).Design/methodology/approachData were obtained from the National Law Enforcement Officers Memorial Fund (NLEOMF) on death frequencies related to health issues at work. Death rates were based on the total number of police officers in the United States [rate = (frequency/population at risk) × 100,000]. Trends were examined using standardized regression.FindingsA total of 646 deaths were attributed to job-related illness. There was a significant upward trend in overall job-related illness deaths (frequency analyses: β = 0.88, p < 0.0001; rate analyses: β = 0.82, p ≤ 0.0001) mainly driven by a significant increase in 911 cancer deaths (frequency analyses: β = 0.88, p < 0.0001; rate analyses: β = 0.88, p ≤ 0.0001). Nearly 82 percent of circulatory deaths were from a heart attack, with an average death age of 46.5 years.Research limitations/implicationsDeaths were not included if they failed to meet medical requirements of the NLEOMF. The data are descriptive, do not estimate risk and should be interpreted cautiously.Practical implicationsPolice wellness programs may help to reduce the danger of deaths associated with job-related illness.Originality/valueThis is among the first studies to examine frequency and rate of police health–related deaths due to job exposures.
Use of blockchain in designing smart city
Authors: Dewan Surbhi , Singh Latika 
Published: March 2020

PurposeA blockchain is a shared distributed ledger technology that stores the information of every transaction in the network. The blockchain has emerged with a huge diversity of applications not only in the economic but in the non-economical domain as well. Blockchain technology promises to provide a wide range of solutions to the problems faced during implementation of smart cities. It has the potential to build smart contracts more secure, thus eliminating the need for centralized authority.Design/methodology/approachThis paper presents a proof-of-concept for a use case that uses an Ethereum platform to build a blockchain network to buy, sell or rent a property.FindingsThe findings of this study provide an opportunity to create novel decentralized scalable solutions to develop smart cities by enabling paperless transactions. There are enormous opportunities in this distributed ledger technology which will bring a revolutionary change in upcoming years.Originality/valueThe concept of blockchain along with smart contracts can be used as a promising technology for sharing services which is a common requirement in smart cities. All the blockchain transactions are stored in decentralized shared database. The transaction recorded in decentralized system is immutable, it cannot be altered and hence chance of forgery is negligible.
Improving physician research training: understanding the student perspective
Authors: Knapke Jacqueline , Haynes Erin N. , Vaughn Lisa M. 
Published: March 2020

PurposeUsing a mixed-methods approach, this study evaluated a Master of Science program in Clinical and Translational Research (MSCTR) geared toward training physicians in research methodology. The purpose of this study is to allow trainees to articulate their expectations, needs and experiences in the MSCTR and to develop novel training methods and/or curriculum modifications to improve physician-scholar training.Design/methodology/approachThe mixed-method study design with qualitative emphasis included interviews, participant journal entries and a survey. Interview and journal entry data were analyzed using a modified seven-stage hermeneutic analysis and survey data were analyzed using descriptive statistics.FindingsFindings suggest three major areas for improvement, namely, curriculum, mentorship/relationships and instructional methods. Concluding recommendations to address these three areas include: make ongoing curriculum updates to provide a sequential pathway but also allow for flexibility, improve statistical training, invest in online courses and create a more structured mentorship program.Originality/valueExtant research, though minimal, has evaluated clinical research training programs in terms of alumni productivity. However, this is the first study of its kind to examine a clinical research training program primarily qualitatively and from the perspective of its students and alumni.
Amino acids effects on heterocyclic amines formation and physicochemical properties in pan‐fried beef patties
Authors: Linghu Ziyi , Karim Faris , Taghvaei Mostafa , Albashabsheh Zaher , Houser Terry A. , Smith J. Scott 
Published: March 2020

AbstractThe effects of surface application of amino acids on the formation of heterocyclic amines (HCAs) and meat quality properties were evaluated in pan‐fried beef patties (230 °C/15 min). Tryptophan, lysine, leucine, and proline at three concentrations, 0.05%, 0.20%, and 0.50% (w/w), were tested. The meat crusts were analyzed for HCA content using liquid chromatography‐tandem mass spectrometry. Results showed that surface application of all tested amino acids significantly reduced total HCA content (P < 0.05), and the interaction of amino acid type and concentration significantly affected (P < 0.05) both individual and total HCA formation. Tryptophan at 0.50% reduced total HCAs the most (0.92 ng/g, 93% inhibition), followed by 0.50% lysine (1.94 ng/g, 84% inhibition), while leucine (3.95 ng/g, 64% inhibition) and proline (4.71 ng/g, 56% inhibition) were less effective at 0.50%. In addition, applying amino acids to meat surface significantly influenced (P < 0.05) pH and surface color change of beef crusts; particularly, lysine at 0.20% and 0.50% increased pH and a* (redness) but reduced b* (yellowness), while tryptophan and leucine at 0.50% increased L* (whiteness). No significant effect was observed on cooking loss. Adding amino acids at 0.50% affected (P < 0.05) formation of aldehydes and pyrazines (as the key flavor compounds of fried beef). Overall, the results of this study suggested that adding amino acids to ground beef patties could effectively mitigate mutagenic HCA formation during cooking.