bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalizability of Convolutional Encoder–Decoder Networks for Aerodynamic Flow-Field Prediction Across Geometric and Physical-Fluidic Variations
Authors: Tangsali Kaustubh , Krishnamurthy Vinayak R. , Hasnain Zohaib 
Published: August 2020

Abstract
The generalizability of a convolutional encoder–decoder based model in predicting aerodynamic flow field across various flow regimes and geometric variation is assessed. A rich master dataset consisting of 11,000+ simulations including cambered, uncambered, thin, and thick airfoils simulated at varying angles of attack is generated. The various Mach and Reynolds number (Re) chosen allows analysis across compressible, incompressible, low, and high Re flow regimes. Multiple studies are carried out with the model trained on datasets that are categorized based on the aforementioned parameters. In each study, the loss of prediction accuracy by training the model on a larger dataset (generalizability), versus a smaller categorically sorted dataset, is evaluated. Largely disparate flow features across the Re range lead to a 25.56% loss, while the generalization across Mach range led to an average of 23.95% loss. However, flow-field changes induced due to geometric variation exhibited a better generalization potential, through an increased accuracy of 12.4%. The encoder–decoder architecture allows extraction of relevant geometric features from largely different geometries (geometric generalization) providing a better out-of-sample prediction accuracy in comparison to physics-based generalization. It is shown that, through user-informed choice of training data (removal of geometrically similar samples), computational costs incurred in generating training data can be reduced. This is important for the application of such methods in the design optimization of platforms and components that require the analysis of the fluid flows.
Effect of Hydrophobic Iron Oxide Nanoparticles on the Properties of Oil-Based Drilling Fluid
Authors: Alvi Muhammad Awais Ashfaq , Belayneh Mesfin , Fjelde Kjell Kåre , Saasen Arild , Bandyopadhyay Sulalit 
Published: August 2020

AbstractLately, nanoparticles (NPs) have shown the potential to improve the performance of oil well fluids significantly. Several studies have reported the ability of NPs to produce improved properties of both water and oil-based drilling fluids. In this study, hydrophobic iron oxide NPs were synthesized by thermal decomposition of iron pentacarbonyl in an inert atmosphere, and its performance was tested in the oil-based drilling fluid with 90/10 oil-to-water ratio (base fluid). Oil-based drilling fluids treated with nanofluids were formulated by adding 0.5 wt% and 1.0 wt% iron oxide NPs in hexane solution to the base drilling fluid. The base fluid and the nanofluid-treated drilling fluids were evaluated by characterizing their rheological properties at different temperatures, viscoelastic properties, lubricity, filtrate loss, static and dynamic settling, and separation properties. Results showed that 0.5 wt% iron oxide dispersed in hexane reduced the high pressure high temperature (HPHT) filtrate loss by 70%, filter cake thickness by 55%, and the coefficient of friction by 39%. Moreover, the nanofluid based drilling fluid reduced the free oil layer caused by syneresis during aging at high temperature by 16.3% compared to the base fluid. This study has shown that hydrophobic iron oxide NPs have the potential to improve the properties of oil-based drilling fluid.
Die Design Architecture for Enhancing Tool Life Via Manipulation of the Elastic Strain Field of the Dies During Extrusion Processes
Authors: Ngaile Gracious , Rodrigues Daniel Santiago 
Published: August 2020

AbstractForging and extrusion tools are often subjected to a combination of cyclic thermo-mechanical, chemical, and tribological loads. Strategies for minimizing these loads are critical for preventing premature tool failure and increasing productivity. A die design architecture for extrusion that minimizes the residual contact pressure at the die-workpiece interface during the ejection stroke is proposed. The underlying principle of this die design is that during the extrusion stroke, a tapered die can move in the direction of the extrusion load, thus inducing negative radial elastic strain on the die. When the extrusion load is removed, the elastic strain energy stored in the die is released, thus repositioning the die to its initial state. With this design architecture, the workpiece can be ejected at no load. The process was validated using finite element (FE) warm forging/extrusion simulations for a constant velocity (CV) joint and pinion gear shaft. These simulations showed that in addition to reducing residual contact pressure, which enhances tribological conditions, the new die design can easily lower die stresses, thus increasing die fatigue life. The FE simulations for CV joint and pinion gear shaft demonstrated residual pressure in certain locations of the die ranging from 30% to 100% of the pressure induced during the extrusion stroke. The case studies simulated showed that a total energy saving of up to 15% can be achieved with the proposed die setup.
Immune-related pneumonitis associated with immune checkpoint inhibitors in lung cancer: a network meta-analysis
Authors: Chen Xinru , Zhang Zhonghan , Hou Xue , Zhang Yaxiong , Zhou Ting , Liu Jiaqing , Lin Zhihuan , Fang Wenfeng , Yang Yunpeng , Ma Yuxiang , Huang Yan , Zhao Hongyun , Zhang Li 
Published: August 2020

BackgroundImmune checkpoint inhibitors (ICIs) have dramatically revolutionized lung cancer treatment, providing unprecedented clinical benefits. However, immune-related pneumonitis (IRP) caused by ICIs has aroused widespread concern due to its high rate of discontinuation and mortality. This network meta-analysis (NMA) aims to compare the risks of IRP among different regimens for advanced lung cancer.MethodsPhase II and III randomized clinical trials (RCTs) were searched from electronic databases. The rates of grade 1–5 IRP and grade 3–5 IRP were systematically extracted. An NMA was conducted among chemotherapy, ICIs monotherapy, dual ICIs combination, and ICIs+chemotherapy. Subgroup analysis was also compared based on specific types of ICIs.ResultsTwenty-five RCTs involving 17,310 patients were eligible for inclusion. Compared with chemotherapy, ICI-based regimens were associated with an increased risk of grade 1–5 IRP and grade 3–5 IRP. Compared with ICIs+chemotherapy, ICIs monotherapy (grade 1–5: OR 2.14, 95% credible interval 1.12 to 4.80; grade 3–5: 3.03, 1.491 to 6.69) and dual ICIs combination (grade 1–5: 3.86, 1.69 to 9.89; grade 3–5: 5.12, 2.01 to 13.68) were associated with a higher risk of grade 1–5 IRP and grade 3–5 IRP. No significant difference was found between dual ICIs combination and ICIs monotherapy in grade 1–5 IRP (1.85, 0.91 to 3.37) or in grade 3–5 IRP (1.65, 0.81 to 3.37). Besides, compared with programmed cell death protein 1 (PD-1) inhibitors (2.56, 1.12 to 6.60), a lower risk of grade 1–5 IRP was observed in programmed cell death ligand 1 (PD-L1) inhibitors.ConclusionCompared with chemotherapy, using ICIs is associated with an increased risk of IRP. ICIs+chemotherapy is associated with a lower risk of IRP compared with dual ICIs combination and ICIs monotherapy. PD-1 inhibitors are associated with a higher risk of 1–5 grade IRP compared with PD-L1 inhibitors.
Comparative construct validity of three presenteeism instruments in workers with musculoskeletal complaints: a prospective cohort study
Authors: van der Burg Lennart , Sepriano Alexandre , Landewé Robert , Geuskens Goedele , Ottenheijm Ramon , Dinant Geert-Jan , Boonen Annelies 
Published: August 2020

ObjectivesTo compare the construct validity of three presenteeism instruments, using health and economic outcomes as external references, among working persons reporting musculoskeletal complaints.MethodsData from the prospective Study on Transitions in Employment, Ability and Motivation were used. Presenteeism measurement comprised a global rating of work-ability, and two instruments indicating at-work productivity, and was assessed yearly over 6 years of follow-up. Longitudinal associations between measures of health and subsequent presenteeism, and between presenteeism and subsequent days of sick leave were assessed using generalised estimating equation models. The effect of groups of contextual factors (socio-demographic, lifestyle, personal and work-related factors) was investigated by assessing the change in explained variability.ResultsIn total, 4523 persons were analysed. The association between physical health and work-ability was stronger than both at-work productivity measures; 10 points increase in physical health (0–100, higher is better) was associated with 0.79 points (95% CI 0.75 to 0.84) better work-ability (0–10, higher is better) in the subsequent year. Besides, work-ability best predicted sick leave; one point higher work-ability was associated with 4 days less sick leave (95% CI −5.09 to −3.63) the subsequent year. Personal factors improved model fit for models on health and work-ability, but conflicting results were seen for both at-work productivity instruments.ConclusionWork-ability showed higher construct validity against health and economic outcomes as compared to at-work productivity, which shows that work-ability is different to productivity (losses). Personal factors are especially relevant when interpreting the relation between health and work-ability or self-reported quantity of work.
Chronic uterine abscess in a Bolivian grey titi monkey (Plecturocebus donacophilus)
Authors: Kaye Sarrah 
Published: August 2020

SUMMARYAn 11‐year‐old, reproductively active female Bolivian grey titi monkey (Plecturocebus donacophilus) in a zoological institution was presented for abdominal distension without concurrent clinical signs. Physical examination and imaging studies detected a uterine mass. Preoperative bloodwork revealed anaemia and hyperglobulinaemia. Hysterectomy was performed, but the patient died under anaesthesia. Histopathological examination found a chronic uterine abscess with effacement of the uterine wall and generalised inflammation consistent with sepsis. This case documents an uncommon reproductive tract lesion in a New World primate, and demonstrates the value of routine reproductive health monitoring in non‐human primates, as not all pathologies will have clinical signs perceptible by caretakers. Earlier diagnosis may have resulted in an improved outcome in this case. Uterine abscess could be a differential diagnosis in cases of abdominal mass effect or distension in female titi monkeys.
Entropic uncertainty relation in neutrino oscillations
Authors: Wang Dong , Ming Fei , Song Xue-Ke , Ye Liu , Chen Jing-Ling 
Published: August 2020

AbstractNeutrino oscillation is deemed as an interesting physical phenomenon and shows the nonclassical features made apparently by the Leggett–Garg inequality. The uncertainty principle is one of the fundamental features that distinguishes the quantum world to its classical counterpart. And the principle can be depicted in terms of entropy, which forms the so-called entropic uncertainty relations (EUR). In this work, the entropic uncertainty relations that are relevant to the neutrino-flavor states are investigated by comparing the experimental observation of neutrino oscillations to predictions. From two different neutrino sources, we analyze ensembles of reactor and accelerator neutrinos for different energies, including measurements performed by the Daya Bay collaboration using detectors at 0.5 and 1.6 km from their source, and by the MINOS collaboration using a detector with a 735km distance to the neutrino source. It is found that the entropy-based uncertainty conditions strengths exhibits non-monotonic evolutions as the energy increases. We also quantify the systemic quantumness measured by quantum correlation, and derive the intrinsic relationship between quantum correlation and EUR. Furthermore, we utilize EUR as a criterion to detect entanglement of neutrino-flavor state. Our results could illustrate the potential applications of neutrino oscillations on quantum information processing in the weak-interaction processes.
The quantum random energy model as a limit of p-spin interactions
Authors: Manai Chokri , Warzel Simone 
Published: August 2020

We consider the free energy of a mean-field quantum spin glass described by a [Formula: see text]-spin interaction and a transversal magnetic field. Recent rigorous results for the case [Formula: see text], i.e. the quantum random energy model (QREM), are reviewed. We show that the free energy of the [Formula: see text]-spin model converges in a joint thermodynamic and [Formula: see text] limit to the free energy of the QREM.
Simple High-Level Code For Cryptographic Arithmetic
Authors: Erbsen Andres , Philipoom Jade , Gross Jason , Sloan Robert , Chlipala Adam 
Published: August 2020

We introduce an unusual approach for implementing cryptographic arithmetic in short high-level code with machinechecked proofs of functional correctness. We further demonstrate that simple partial evaluation is sufficient to transform such initial code into highly competitive C code, breaking the decades-old pattern that the only fast implementations are those whose instruction-level steps were written out by hand.
These techniques were used to build an elliptic-curve library that achieves competitive performance for a wide range of prime fields and multiple CPU architectures, showing that implementation and proof effort scales with the number and complexity of conceptually different algorithms, not their use cases. As one outcome, we present the first verified highperformance implementation of P-256, the most widely used elliptic curve. Implementations from our library were included in BoringSSL to replace existing specialized code, for inclusion in several large deployments for Chrome, Android, and CloudFlare.
This is an abridged version of the full paper originally presented in IEEE S&P 2019 [10]. We have omitted most proof-engineering details in favor of a focus on the system's functional capabilities.
ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen
Authors: Su Yang , Zhang Xin , Bidlingmaier Scott , Behrens Christopher R. , Lee Nam-Kyung , Liu Bin 
Published: August 2020

Abstract

Identification of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal tissues. In mesothelioma, we identified a highly specific tumor cell surface antigen that can be targeted for therapy development. Mesothelioma is caused by malignant transformation of the mesothelium, is incurable, and can be categorized into three histologic subtypes: epithelioid, biphasic, and sarcomatoid. To identity novel mesothelioma cell surface antigens with broad subtype coverage and high tissue specificity, we have previously selected phage antibody display libraries on live mesothelioma cells and tissues following counterselection on normal cells and identified a panel of human antibodies that bind all subtypes of mesothelioma, but not normal mesothelium. One of the antibodies, M25, showed high specificity against an antigen we identify here as ALPPL2. IHC on normal human tissues found that ALPPL2 is expressed only on placental trophoblasts, but not on any other normal tissues. This significant tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against mesothelioma. To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-targeted antibody–drug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma. Thus, ALPPL2 belongs to a rare class of cell surface antigens classified as truly tumor specific and is well suited for therapy development against ALPPL2-expressing tumors.

Significance:
These findings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables the development of novel therapies.
Atrial Fibrillation Screen, Management, and Guideline‐Recommended Therapy in the Rural Primary Care Setting: A Cross‐Sectional Study and Cost‐Effectiveness Analysis of eHealth Tools to Support All Stages of Screening
Authors: Orchard Jessica , Li Jialin , Freedman Ben , Webster Ruth , Salkeld Glenn , Hespe Charlotte , Gallagher Robyn , Patel Anushka , Kamel Bishoy , Neubeck Lis , Lowres Nicole 
Published: August 2020

BACKGROUND
Internationally, most atrial fibrillation (AF) management guidelines recommend opportunistic screening for AF in people ≥65 years of age and oral anticoagulant treatment for those at high stroke risk (CHA₂DS₂‐VA≥2). However, gaps remain in screening and treatment.

METHODS AND RESULTS

General practitioners/nurses at practices in rural Australia (n=8) screened eligible patients (≥65 years of age without AF) using a smartphone ECG during practice visits. eHealth tools included electronic prompts, guideline‐based electronic decision support, and regular data reports. Clinical audit tools extracted de‐identified data. Results were compared with an earlier study in metropolitan practices (n=8) and nonrandomized control practices (n=69). Cost‐effectiveness analysis compared population‐based screening with no screening and included screening, treatment, and hospitalization costs for stroke and serious bleeding events. Patients (n=3103, 34%) were screened (mean age, 75.1±6.8 years; 47% men) and 36 (1.2%) new AF cases were confirmed (mean age, 77.0 years; 64% men; mean CHA₂DS₂‐VA, 3.2). Oral anticoagulant treatment rates for patients with CHA₂DS₂‐VA≥2 were 82% (screen detected) versus 74% (preexisting AF)(
P
=NS), similar to metropolitan and nonrandomized control practices. The incremental cost‐effectiveness ratio for population‐based screening was AU$16 578 per quality‐adjusted life year gained and AU$84 383 per stroke prevented compared with no screening. National implementation would prevent 147 strokes per year. Increasing the proportion screened to 75% would prevent 177 additional strokes per year.

CONCLUSIONS
An AF screening program in rural practices, supported by eHealth tools, screened 34% of eligible patients and was cost‐effective. Oral anticoagulant treatment rates were relatively high at baseline, trending upward during the study. Increasing the proportion screened would prevent many more strokes with minimal incremental cost‐effectiveness ratio change. eHealth tools, including data reports, may be a valuable addition to future programs.

REGISTRATION

URL:
https://www.anzctr.org.au
. Unique identifier: ACTRN12618000004268.
Business for Climate: A Qualitative Comparative Analysis of Policy Support from Transnational Companies
Authors: Witte Daniel 
Published: August 2020

AbstractTransnational companies (TNCs) are becoming increasingly influential in the global governance of climate change. Therefore, it is of paramount importance to understand the factors that explain why some TNCs broadly support policies to tackle climate change, while others oppose them. This study subjects previous findings from small-N case studies to a more systematic fuzzy set qualitative comparative analysis (fsQCA). It investigates previous findings that link exposure to fossil fuels to policy opposition, and transnational operations, exposure to consumers, certain factors in the institutional environment, and pressure from investors to policy support. The study concludes that findings from small-N case literature can explain the necessary conditions for climate policy support in a larger set of TNCs from a wider variety of sectors and geographies beyond GHG-intensive sectors, such as retail, technology, and telecommunication. It concludes by suggesting areas and cases for further research.
Experiments in EU Climate Governance: The Unfulfilled Potential of the Covenant of Mayors
Authors: Domorenok Ekaterina , Acconcia Giuseppe , Bendlin Lena , Campillo Xira Ruiz 
Published: August 2020

Abstract
Over the last decade, a growing body of academic literature has reflected on how and under which conditions experiments in global climate governance lead to broader changes in rules, norms, and practices helping to meet the challenge of climate change. Drawing on the assumptions of the scholarship on experimentalist governance architectures, this article analyzes the effectiveness of the Covenant of Mayors (CoM) as a comprehensive governance framework that enables the development and coordination of local policies for sustainable energy and climate through a range of joint instruments for recursive goal setting, monitoring, and benchmarking. Our findings illustrate the CoM’s significant potential in terms of both general political uptake and policy output, which could make of this program, if appropriately fine-tuned, a successful governance experiment contributing to building a more effective global climate regime.
Climatic Shift of the Tropical Cyclone Activity Affecting Vietnam’s Coastal Region
Authors: Tran-Quang Duc , Pham-Thanh Ha , Vu The-Anh , Kieu Chanh , Phan-Van Tan 
Published: August 2020

AbstractThis study examines the climatic shift of the tropical cyclone (TC) frequency affecting Vietnam’s coastal region during 1975–2014. By separating TC databases into two different 20-yr epochs, it is found that there is a consistent increase in both the number of strong TCs and the number of TC occurrences during the recent epoch (1995–2014) as compared with the reference epoch (1975–94) across different TC databases. This finding suggests that not only the number of strong TCs but also the lifetime of strong TCs affecting Vietnam’s coastal region has been recently increasing as compared with the reference epoch from 1975 to 1994. To understand the physical connection of these shifts in the TC frequency and duration, large-scale conditions obtained from reanalysis data are analyzed. Results show that meridional surface temperature gradient (STG) during the recent epoch is substantially larger than that during 1975–94. Such an increase in the meridional STG is important because it is potentially linked to the increase in large-scale vertical wind shear as well as the reduced intensity of summer monsoon in the South China Sea between the two epochs.