bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Practice Patterns Among Canadian Primary Care Physicians: Cross-Provincial Analysis of Linked Health Data
Authors: Lavergne M. Ruth , Peterson Sandra , Ahuja Megan , Rudoler David , Goldsmith Laurie J , Grudniewicz Agnes , Marshall Emily Gard 
Published: December 2020

IntroductionCanadians report persistent problems accessing primary care despite an increasing per-capita supply of primary care physicians (PCPs). There is speculation that PCPs, especially those early in their careers, may be working less and/or choosing to practice in focused clinical areas rather than comprehensive family medicine.
Objectives and ApproachOur objectives were to compare practice patterns among early-career (<10 years in practice) and established (10+ years) PCPs and to determine if any changes over time reflect cohort effects (attributes unique to recent cohorts of PCPs), or period effects (changes over time across all PCPs). We accessed linked population and physician registry data, physician billing data, hospital discharge records, and vital statistics in each of three Canadian provinces from 1996/7 to 2017/8. Physician fee schedules are negotiated separately by province which means that while fields capturing service dates, dollars billed, and diagnosis codes are directly comparable, other fields capture similar, but not identical information across provinces (e.g. specific fee codes and service location codes). We developed measures of services volume, continuity, and comprehensiveness of primary care that could be applied across provinces and used these to describe practice patterns over two decades and explore cohort and period effects.
ResultsMeasures of service volume (total patient contacts, number of unique patients seen) and continuity are lower among early-career physicians but the gap between early-career and established physicians has not changed. Measures of comprehensiveness of care, including provision of services in home, long-term care, hospital, and emergency department, as well as indicators of focused practice, hospitalist and locum care show more varied patterns, with declines in comprehensiveness across all physicians, but more evidence of focused practice among early-career physicians.
Conclusion / ImplicationsFindings have implications both for health workforce planning and organizational reforms to support access to comprehensive primary care.
A POST-TRUTH CULTURISM AND ITS DELUSIONS
Authors: Naranjo Navas Christian Paúl , Naranjo Navas Bryan Josue , Naranjo Navas Bryan Josue 
Published: December 2020

In a postmodern culturism, everything is relative, in this way, nothing can be affirmed as absolute truth. Taking into account that culturism is the belief that some cultures are superior than others, this essay proposes the idea that a postmodern culturism is the belief, superior to others, that all cultures are to be revered. Within a postmodern culturism, the essay proposes the analysis of three common arguments through a specific epistemological perspective, rationalism: empirical data and the primacy of reason. The analyzed arguments are: first, all cultures ought to be equally revered; second, western logic is different to the ancestral logic; third, all ancestral cultures have wisdom. The article concludes that these arguments do not withstand the rational analysis.
Tula sin censura: un recorrido por la otra versión del clásico de Miguel Picazo
Authors: Suñé Minguella Gemma 
Published: December 2020

Desde su éxito en el Festival Internacional de cine de San Sebastián en 1964, La tía Tula de Miguel Picazo se convirtió en uno de los hitos del “Nuevo cine español” y, con el tiempo, en uno de nuestros clásicos. Sin embargo, tal y como profetizó el propio García Escudero, Director General de Cinematografía durante esos años de “aperturismo” del régimen franquista, el perjuicio de haber sido censurada en exceso no ha dejado de acompañarla casi como un atributo ya inherente a ella. Además, el hecho de que se destruyeran los negativos censurados no habría hecho sino contribuir a esta leyenda.
Nos proponemos en este artículo comparar la película que ha llegado hasta nosotros con el guion publicado en 2005 en ocasión del 40 aniversario de su estreno. Para ello tendremos en cuenta, no sólo las escenas y planos cortados por la censura, sino también todas aquellas modificaciones realizadas por el propio Picazo en su tarea de poner en escena su obra. Nuestro recorrido nos desvelará una versión más compleja y matizada de los principales personajes, así como un retrato mucho más minucioso, incisivo y hasta mordaz de la sociedad provinciana de principios de los años sesenta.
Hematemesis caused by eosinophilic gastritis in infancy
Authors: Asif Uswah , Yankov Ivan , Belovezhdov Veselin , Grozeva Dafina , Gulinac Milena , Genova Sylvia 
Published: December 2020

Background:
Eosinophilic gastritis is an eosinophilic inflammation of the stomach mucosa characterized by eosinophilia in the absence of other known causes. It is usually the result of contact with a food allergen. Allergy to cow’s milk is one of the possible reasons. It often presents with different symptoms, one of these being hematemesis. From the current literature, we know that eosinophilic disease can result in severe tissue damage.

Case presentation:
We report two patients who were admitted to the gastroenterology department with severe hematemesis and were diagnosed via gastroscopy with the rare presentation of erosive gastropathy. Our patients eventually recovered after initiation of hydrolyzed milk.

Conclusion:
It is important to consider gastroscopy to aid in the rapid diagnosis of eosinophilic gastritis, even in the case of a relatively young child. This is because the strongest evidence for diagnosis is histological biopsy.
Power of 3D Transrectal Ultrasonography and Magnetic Resonance Imaging in Diagnosis of Cryptogenic Rectal Fistulae
Authors: Kiselev D. O. , Zarodnyuk I. V. , Trubacheva Yu. L. , Eligulashvili R. R. , Мatinyan A. V. , Kostarev I. V. 
Published: December 2020

Background. The only radical curative treatment for rectal ﬁstulae is surgery. The choice of surgery requires precise characterisation of the ﬁstulous tract. The most common instrumental methods for rectal ﬁstula diagnosis are transrectal ultrasonography (TRUS) and magnetic resonance imaging (MRI).Objectives. Comparative assessment of the diagnostic power of 3D TRUS and MRI techniques in revealing cryptogenic anal ﬁstulae with respect to intraoperative examination.Methods. The study enrolled 92 patients with rectal ﬁstulae aged 27 to 66 years. Fistulous opening was external in 47 (51.1%) and obliterated in 45 (48.9%) patients. The average patient age was 42.7 ± 15.9 years. Surgery for acute paraproctitis 14 to 32 days prior to examination was in history of 58 (63.1%) patients. All patients had preoperative subsequent 3D TRUS and MRI compared with intraoperative examination results.Results. The rate of correct ﬁstulous tract type diagnosis veriﬁed with intraoperative revision was 96.7% (89/92) with 3D TRUS and 82.6% (76/92) with MRI (p = 0.0027). The error rate of 3D TRUS estimation of external sphincter involvement was 1.1% (1/92), sensitivity 96.6%, speciﬁcity 93.5%, overall accuracy 94.5%. The MRI error rate was 21.7% (20/92), with a statistically signiﬁcant difference for sensitivity and overall accuracy (p < 0.0001). The rate of correct estimation of internal ﬁstulous localisation in “anorectal clock” was 97.8% (90/92) with 3D TRUS and 90% (81/90) with MRI (p = 0.0342). Internal ﬁstula was not detected with MRI in 2/92 (2.2%) cases, which explains the deviation. Intraoperative revision identiﬁed total 113 abscesses. The rate or correct abscess estimation was 97.3% (110/113) with 3D TRUS and 74.7% (71/95) with MRI. MRI failed to detect abscess in 18/113 (15.9%) cases (p < 0.0001).Conclusion. 3D transrectal ultrasonography is statistically superior over magnetic resonance imaging in estimating internal ﬁstula localisation in “anorectal clock”, ﬁstulous type, as well as the ﬁstulous tract location relative to external sphincteric tissue in patients with transsphincteric anal ﬁstulae. Estimation of pararectal and intramural abscesses was also signiﬁcantly different.
Absence of contrast enhancement in a petroclival meningioma: Case report and systematic literature review
Authors: Adepoju Adedamola , Narayan Ananth , Aldyab Mahmoud , Foyt David , Peris-Celda Maria 
Published: December 2020

Background:
Meningioma is one of the most common intracranial tumors with well-established radiologic features such as contrast enhancement, dural tail, and hyperostosis on computed tomography and magnetic resonance imaging. Contrast enhancement is usually homogeneous or heterogeneous based on tumor vascularity and underlying histopathology. Even in this context, faint or nonenhancing meningioma is exceedingly rare.

Case Description:
A 57-year-old male presented with progressive right hearing loss, disequilibrium, occasional difficulty swallowing, and facial numbness. Imaging demonstrated an extensive hypodense, nonenhancing right cerebellopontine angle mass extending from the interpeduncular, and ambient cisterns to the foramen magnum. The pathological analysis demonstrated a microcystic meningioma WHO Grade I. There are few reported case reports or series of minimal or nonenhancing meningiomas, and a systematic review was performed for these cases. Seven peer-reviewed articles with 14 verifiable cases were identified and reviewed for radiologic features, tumor location, and tumor classification. The majority of minimal or nonenhancing meningiomas were microcystic, and most of them located at the convexity. This is the second case reported of a nonenhancing meningioma at the cerebellopontine angle and petroclival region

Conclusion:
Meningioma should be considered a differential diagnosis for nonenhancing lesion at the cerebellopontine and petroclival regions.
Results of the work of the geneticist's office of the Medical Genetic Consultation of the Astrakhan Region for the period 2017-2019
Authors: Николаева О.П. , Рипп С.В. , Грященко В.Н. 
Published: December 2020

Представлены сводные данные по деятельности медико-генетической консультации Астраханской области за период 2017-2019 годов.
Summary data on the activities of the medical and genetic consultation of the Astrakhan region for the period 2017-2019 are presented.
RASopathies in multidisciplinary pediatric hospita
Authors: Журкова Н.В. , Гандаева Л.А. , Пушков А.А. , Басаргина Е.Н. , Пахомов А.В. , Труфанов С.К. , Алексеева А.Ю. , Савостьянов К.В. 
Published: December 2020

RAS-патии - группа наследственных заболеваний, возникающая вследствие нарушения регуляции функции RAS/MAPK внутриклеточных путей (Ras/mitogen-activated protein kinase). Суммарная частота заболеваний данной группы - 1 случай на 1000 новорожденных. Наиболее часто среди RAS-патий встречается синдром Нунан. В настоящее время описано 13 генов, мутации которых отвечают за развитие данного заболевания, включая ген SHOC2, ассоциированный с Нунан-подобным синдромом и измененной структурой волос (Noonan-like syndrome with loose anagen hair) и ген LZTR1, мутации в котором приводят к развитию синдрома Нунан, тип 2 с аутосомно-рецессивным типом наследования.
RASopathies - group of inherited diseases, caused by mutations in genes, encoding components or regulators of the Ras/mitogen-activated protein kinase (MAPK) pathway. We identified 28 patients with inherited diseases from RASopathies: 61% - with Noonan syndrome, 14 % - with Cardiofaciocutaneous syndrome, 14% - with Costello syndrome - 11% - Noonan syndrome-like with loose anagen hair. Mutation c.770C>T, p.S257L in RAF1gene is most common in hypertrophic cardiomyopathy patients with Noonan syndrome. All patients with Noonan syndrome-like with loose anagen hair have mutation c.4A>G , p.S2G in SHOC2 gene.
Phenotype-genotype correlations in patients with inherited ABCA4-associated retinal diseases
Authors: Шеремет Н.Л. , Грушкэ И.Г. , Жоржоладзе Н.В. , Ронзина И.А. , Кадышев В.В. , Алексеева Е.А. , Танас А.С. , Стрельников В.В. 
Published: December 2020

Целью исследования было охарактеризовать клинико-генетические корреляции у пациентов с ABCA4-ассоциированными наследственными заболеваниями сетчатки (НЗС). Распространенная «мягкая» мутация АВСА4:p.G1961E была обнаружена у 20 из 54 больных, наблюдающихся с НЗС и имеющих, по крайней мере, одну мутацию в гене АВСА4. У 8 пациентов p.G1961E выявлена в компаунд-гетерозиготном состоянии с комплексной миссенс-мутацией p.[L541P;A1038V], у 6 - с другими миссенс-мутациями (p.N1805D; p.R1640W; p.P1088T; p.L541P; p.P1380L; p.R1640Q). В нашей выборке у пациентов с длительностью заболевания от 9 лет мутация p.G1961E в 81% случаев ассоциирована с лёгким течением НЗС, даже при наличии второй тяжелой мутации, и является предиктором более легкого течения заболевания, в соответствии с базовой моделью клинико-генетических корреляций при АВСА4-ассоциированных заболеваниях.
The aim of this study was to characterize phenotype-genotype correlations in patients with ABCA4-associated IRDs. By NGS, we have identified the widespread “mild” ABCA4 mutation p.G1961E in 20 of 54 IRD patients with at least one mutation in the ABCA4 gene. In 8 patients, p.G1961E was in combination with a complex missense mutation p. [L541P; A1038V], in six - in combination with other missense mutations (p.N1805D; p.R1640W; p. P1088T; p.L541P; p.P1380L; p.R1640Q). In 81% of our patients with a disease course of 9 years or more, the p.G1961E mutation is associated with mild disease, even in the presence of a second severe mutation, and is a predictor of a milder phenotype, in accordance with the basic model of phenotype-genotype correlations in ABCA4-associated diseases.
Prenatal case of detection of the asphyxiating thoracic dystrophy (Jeune syndrome)
Authors: Синельникова И.А. , Сопрунова И.В. , Грященко В.Н. , Николаева О.П. , Калинина Е.А. 
Published: December 2020

Асфиктическая дисплазия грудной клетки представляет собой редкое аутосомно-рецессивное наследственное заболевание, которое характеризуется узкой грудной клеткой, короткими рёбрами, укороченными трубчатыми костями, возможно сочетание этих симптомов с полидактилией, аномалиями мозга, сердца, почек, печени, поджелудочной железы. В статье представлен случай пренатального выявления синдрома асфиктической дисплазии грудной клетки (синдром Жене)
Short-rib thoracic dysplasia (SRTD) is an autosomal recessive disorder characterized by a constricted thoracic cage, short-ribs, shortened tubular bones, polydactyly is variably present. The visceral malformation can include anomalies brain, heart, kidneys, liver, pancreas. We present a case report of prenatally diagnosed Short-rib thoracic dysplasia (SRTD) syndrome.
Associations of rs1801197 polymorphism of the calcitonin receptor gene CALCR with postmenopausal osteoporosis
Authors: Резниченко Н.А. , Адунц А.Г. 
Published: December 2020

Обследовано 116 женщин в постменопаузе. Установлено неравномерное распределение генотипов полиморфизма rs1801197 гена CALCR в группах здоровых женщин, пациентов с остеопорозом и остеопенией (р=0,036). Среди женщин с остеопорозом и остеопенией по сравнению со здоровыми лицами значительно чаще регистрируется аллель С (p<0,001).
We examined 116 postmenopausal women. An uneven distribution of the rs1801197 polymorphism genotypes of the CALCR gene was found in the groups of healthy women, patients with osteoporosis and osteopenia (p = 0.036). Among women with osteoporosis and osteopenia, compared with healthy individuals, the C allele is significantly more often recorded (p <0.001).
Verification of a syndrome with a high degree of genetic heterogeneity and clinical polymorphism
Authors: Галкина В.А. , Миронович О.Л. , Зинченко Р.А. 
Published: December 2020

Наследственные синдромы множественных врожденных пороков развития (МВПР) - большая группа хромосомных и моногенных заболеваний, насчитывающая в настоящее время более 3-х тысяч форм. Диагностика и верификация синдромов МВПР часто бывает затруднительной в силу многообразия форм, межсемейного и внутрисемейного клинического полиморфизма, и при спорадических случаях заболевания наиболее достоверной будет при полном комплексе фенотипических признаков. Кроме того дифференциальная диагностика также может быть затруднена в силу схожести фенотипических признаков при разных синдромах. В подобных случаях проблему уточнения диагноза и решения вопроса о возможности проведения в семье пренатальной диагностики при последующей беременности может решить применение методов высокопроизводительного секвенирования ДНК (NGS). В результате NGS диагностирован редкий вариант синдрома Жубера, без молекулярно-генетической верификации диагностика была бы затруднительна.
Нereditary syndromes of multiple congenital malformations (MCM) are a large group of chromosomal and monogenic diseases, currently reaching more than 3 thousand forms. Diagnosis and verification of MCM syndromes is often difficult due to the variety of forms, inter-family and intra-family clinical polymorphism, and in sporadic cases, the most reliable will be with a full set of phenotypic features. In addition, differential diagnosis can also be difficult due to the similarity of phenotypic features in different syndromes. In such cases, the use of high-performance DNA sequencing methods can solve the problem of clarifying the diagnosis and resolving the issue of whether prenatal diagnosis of the disease in the fetus can be carried out in the family during subsequent pregnancy. As a result, NGS diagnosed a rare variant of Joubert syndrome, without molecular genetic verification, diagnosis would be difficult.
The study of gene polymorphisms, involved in the metabolism of beta-2-agonists and histamine, in the development and course of asthma
Authors: Савельева О.Н. , Карунас А.С. , Федорова Ю.Ю. , Мурзина Р.Р. , Савельева А.Н. , Актаева Е.Е. , Гатиятуллин Р.Ф. , Эткина Э.И. , Загидуллин Ш.З. , Хуснутдинова Э.К. 
Published: December 2020

Бронхиальная астма (БА) является одним из наиболее распространенных тяжелых и инвалидизирующих хронических заболеваний многофакторной природы. Показано, что до 50-60 % чувствительности к терапии БА обусловлено генетической вариабельностью. Проведено исследование полиморфных вариантов генов, участвующих в метаболизме бета-2-агонистов (CRHR2, ADCY9, THRB, SPATS2L) и гистамина (AOC1, HRH4) у пациентов с БА и в контрольной группе индивидов различной этнической принадлежности.
Asthma is one of the most common severe and disabling chronic diseases. It has been shown that up to 50-60% of sensitivity to asthma therapy is due to genetic variability. The study of polymorphisms of genes involved in the metabolism of beta-2-agonists (CRHR2, ADCY9, THRB, SPATS2L) and histamine (AOC1, HRH4) in asthma patients and individuals of the control group of different ethnicities were carried out.
Paclitaxel-induced disorders in hematopoietic progenitor cells as a possible cause of the development of distant genoand myelotoxicity in CBA mice
Authors: Федорова Е.П. , Неупокоева О.В. , Ставрова Л.А. , Воронова О.Л. , Сандрикина Л.А. , Чурин А.А. 
Published: December 2020

Выявлено генотоксичное воздействие паклитаксела на хромосомный материал дифференцированных клеток костного мозга самцов и самок мышей в ранние и отдаленные сроки исследования. Установлено, что в эти же сроки наблюдения паклитаксел вызывает гипоплазию костного мозга и снижает в костном мозге экспериментальных животных количество ранних клеток-предшественников эритропоэза, а также способствует уменьшению их пролиферативного потенциала независимо от пола.
The genotoxic effect of paclitaxel on the chromosomal material of differentiated bone marrow cells in male and female mice was revealed in the early and long-term periods of the study. It was found that during the same observation period paclitaxel causes bone marrow hypoplasia and reduces the number of early erythropoiesis progenitor cells in the bone marrow of experimental animals, and also contributes to a decrease in their proliferative potential regardless of gender.
Molecular-cytogenetics characteristics for cancerogenic risk estimation in I-II generations of irradiated persons
Authors: Балева Л.С. , Сипягина А.Е. , Сухоруков В.С. , Карахан Н.М. , Егорова Н.И. 
Published: December 2020

Исследована значимость геномной нестабильности и процессов мутагенеза для механизмов формирования онкологических заболеваний и наличие трансгенерационного феномена у I-II поколений, подвергшихся действию радиационного фактора.
The significance of genomic instability and mutagenesis processes in the mechanisms of cancer formation and the presence of transgenerational phenomenon in I-II generations exposed to the radiation factor was investigated.
Knowledge and awareness towards intrauterine contraceptive devices among Indian women in the reproductive age group in a tertiary care teaching hospital
Authors: Rufas S  , Parimala A  
Published: December 2020

Intrauterine contraceptive device (IUCD) is convenient, a one-time procedure, OP procedure, long-acting, cheap, having less side effects and reversal of fertility is soon after removal, makes it suitable temporary contraception. To improve its usage and to improve the Nation's economy by uplifting family health is by creating awareness among women. This can be achieved by counselling, health talks, educating them. These targets can be met during their visit to hospitals for general ailment or by public awareness programs. The objective of this study is to evaluate knowledge, awareness towards the IUCD among Indian women in the reproductive age group (18 to 45 years) in a tertiary care teaching hospital. A Cross-Sectional Mixed Research from January 2019 to June 2019 was done among patients in the age group of 18-45 years attending the outpatient department of a tertiary care teaching hospital. The analysed results showed only 63% of participants were aware about the need for birth spacing and limiting child birth. 47% of participants interviewed knew that the device is used to prevent pregnancy while the rest didn't even know what an IUCD is. This survey concludes poor awareness about the IUCD among women in the study group. We have to improve the awareness and usage of IUD with proper health education and counselling.
ANALISIS PEMBELAJARAN MATA KULIAH AUDITING (KOMPENTENSI DALAM AUDITOR JUDGMENT )
Authors: Wibowo Ery . 
Published: December 2020

Abstrak proses pembelajaran mata kuliah auditing tidak bisa ditepaskan dengan tuntutan dunia praktik. Penerapan ilmu Auditing sebagai dasar kompetensi bagi profesi Auditor dalam dunia praktik membutuhkan perspeitif ilmu yang sangat luas. Pada prakteknya seorang Auditor tidak hanya cukup berbekal pemahaman secara kognisi terhadap ilmu Auditing yang berbasis pada ilmu akuntansi semata. Tetapi juga harus dituntut memiliki kemampuan interaksi sosial (soft skill). Makalah ini merupakan studi pustaka untuk mencoba membuat alur dalam mendisain sebuah proses pembelajaran bogi mata kuliah auditing yang memiliki dasar kompetensi bagi profesi Auditor. Kata kunci: pembelajaran, soft skill, audit djugment, kompentensi