bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Management of Poststroke Patients With a Smartphone-Based Management System Integrated in Clinical Care: Prospective, Nonrandomized, Interventional Study
Authors: Kim Do Yeon , Kwon Hee , Nam Ki-Woong , Lee Yongseok , Kwon Hyung-Min , Chung Young Seob 
Published: December 2019

Background
Advances in mobile health (mHealth) have enabled systematic and continuous management of patients with chronic diseases.

Objective
We developed a smartphone-based mHealth system and aimed to evaluate its effects on health behavior management and risk factor control in stroke patients.

Methods
With a multifaceted stroke aftercare management system that included exercise, medication, and educational materials, we performed a 12-week single-arm intervention among eligible poststroke patients in the stroke clinic from September to December 2016. The intervention consisted of (1) regular blood pressure (BP), blood glucose, and physical activity measurements; (2) stroke education; (3) an exercise program; (4) a medication program; and (5) feedback on reviewing of records by clinicians. Clinical assessments consisted of the stroke awareness score, Beck Depression Inventory-II (BDI), EuroQol-5 Dimensions (EQ-5D), and BP at visit 1 (baseline), visit 2 (4 weeks), and visit 3 (12 weeks). Temporal differences in the parameters over 12 weeks were investigated with repeated-measures analysis of variance. Changes in medication adherence at visit 1-2 (from visit 1 to visit 2) and visit 2-3 (from visit 2 to visit 3) were compared. System satisfaction was evaluated with a self-questionnaire using a 5-point Likert scale at visit 3.

Results
The study was approved by the Institutional Review Board in September 2016, and participants were enrolled from September to December 2016. Among the 110 patients enrolled for the study, 99 were included in our analyses. The mean stroke awareness score (baseline: 59.6 [SD 18.1]; 4 weeks: 67.6 [SD 16.0], P<.001; 12 weeks: 74.7 [SD 14.0], P<.001) and BDI score (baseline: 12.7 [SD 10.1]; 4 weeks: 11.2 [SD 10.2], P=.01; 12 weeks: 10.7 [SD 10.2], P<.001) showed gradual improvement; however, no significant differences were found in the mean EQ-5D score (baseline: 0.66 [SD 0.33]; 4 weeks: 0.69 [SD 0.34], P=.01; 12 weeks: 0.69 [SD 0.34], P<.001). Twenty-six patients who had uncontrolled BP at baseline had −13.92 mmHg (P=.001) and −6.19 mmHg (P<.001) reductions on average in systolic and diastolic BP, respectively, without any antihypertensive medication change. Medication compliance was better at visit 2-3 (60.9% [SD 37.2%]) than at visit 1-2 (47.8% [SD 38.7%], P<.001).

Conclusions
Awareness of stroke, depression, and BP was enhanced when using the smartphone-based mHealth system. Emerging mHealth techniques have potential as new nonpharmacological secondary prevention methods because of their ubiquitous access, near real-time responsiveness, and comparatively lower cost.
Mutual-Aid Mobile App for Emergency Care: Feasibility Study
Authors: Chien Shuo-Chen , Islam Md Mohaimenul , Yeh Chen-An , Chien Po-Han , Chen Chun You , Chin Yen-Po , Lin Ming-Chin 
Published: December 2019

Background
Improving the quality of patient care through the use of mobile devices is one of the hot topics in the health care field. In unwanted situations like an accident, ambulances and rescuers often require a certain amount of time to arrive at the scene. Providing immediate cardiopulmonary resuscitation (CPR) to patients might improve survival.

Objective
The primary objective of this study was to evaluate the feasibility of an emergency and mutual-aid app model in Taiwan and to provide a reference for government policy.

Methods
A structured questionnaire was developed as a research tool. All questionnaires were designed according to the technology acceptance model, and a Likert scale was used to measure the degree of agreement or disagreement. Moreover, in-depth interviews were conducted with six experts from medical, legal, and mobile app departments. Each expert was interviewed once to discuss feasible countermeasures and suggestions. Statistical Package for the Social Sciences (SPSS version 19; IBM Corp, Armonk, New York) was used to perform all statistical analyses, including descriptive statistics, independent sample t-tests, variance analysis, and Pearson correlation analysis.

Results
We conducted this study between October 20, 2017, and November 10, 2017, at the Taipei Medical University Hospital. Questionnaires were distributed to medical personnel, visiting guests, family members, and volunteers. A total of 113 valid questionnaires were finally obtained after the exclusion of incomplete questionnaires. Cronbach α values for self-efficacy (perceived ease of use), use attitude (perceived usefulness), and use willingness and frequency were above .85, meeting the criterion of greater than .70. We observed that the reliability of each subquestion was acceptable and the values for use attitude (perceive usefulness) and use willingness and frequency were more than .90.

Conclusions
The findings suggest that perceived ease of use and perceived usefulness of the app model affect use willingness. However, perceived usefulness had an intermediary influence on use willingness. Experts in law, medical, and technology fields consider that an emergency and mutual-aid model can be implemented in Taiwan. Along with the development of an emergency and mutual-aid app model, we recommend an increase in the number of automated external defibrillators per region and promotion of correct knowledge about CPR in order to decrease morbidity and mortality.
Social Media Strategies for Health Promotion by Nonprofit Organizations: Multiple Case Study Design
Authors: Vedel Isabelle , Ramaprasad Jui , Lapointe Liette 
Published: December 2019

Background
Nonprofit organizations have always played an important role in health promotion. Social media is widely used in health promotion efforts. However, there is a lack of evidence on how decisions regarding the use of social media are undertaken by nonprofit organizations that want to increase their impact in terms of health promotion.

Objective
The aim of this study was to understand why and how nonprofit health care organizations put forth social media strategies to achieve health promotion goals.

Methods
A multiple case study design, using in-depth interviews and a content analysis of each social media strategy, was employed to analyze the use of social media tools by six North American nonprofit organizations dedicated to cancer prevention and management.

Results
The resulting process model demonstrates how social media strategies are enacted by nonprofit organizations to achieve health promotion goals. They put forth three types of social media strategies relative to their use of existing information and communication technologies (ICT)—replicate, transform, or innovate—each affecting the content, format, and delivery of the message differently. Organizations make sense of the social media innovation in complementarity with existing ICT.

Conclusions
For nonprofit organizations, implementing a social media strategy can help achieve health promotion goals. The process of social media strategy implementation could benefit from understanding the rationale, the opportunities, the challenges, and the potentially complementary role of existing ICT strategies.
Exploring Abnormal Behavior Patterns of Online Users With Emotional Eating Behavior: Topic Modeling Study
Authors: Hwang Youjin , Kim Hyung Jun , Choi Hyung Jin , Lee Joonhwan 
Published: December 2019

Background
Emotional eating (EE) is one of the most significant symptoms of various eating disorders. It has been difficult to collect a large amount of behavioral data on EE; therefore, only partial studies of this symptom have been conducted. To provide adequate support for online social media users with symptoms of EE, we must understand their behavior patterns to design a sophisticated personalized support system (PSS).

Objective
This study aimed to analyze the behavior patterns of emotional eaters as the first step to designing a personalized intervention system.

Methods
The machine learning (ML) framework and Latent Dirichlet Allocation (LDA) topic modeling tool were used to collect and analyze behavioral data on EE. Data from a subcommunity of Reddit, /r/loseit, were analyzed. This dataset included all posts and feedback from July 2014 to May 2018, comprising 185,950 posts and 3,528,107 comments. In addition, deleted and improperly collected data were eliminated. Stochastic gradient descent–based ML classifier with an accuracy of 90.64% was developed to collect refined behavioral data of online users with EE behaviors. The expert group that labeled the dataset to train the ML classifiers included a medical doctor specializing in EE diagnosis and a nutritionist with profound knowledge of EE behavior. The experts labeled 5126 posts as EE (coded as 1) or others (coded as 0). Finally, the topic modeling process was conducted with LDA.

Results
The following 4 macroperspective topics of online EE behaviors were identified through linguistic evidence regarding each topic: addressing feelings, sharing physical changes, sharing and asking for dietary information, and sharing dietary strategies. The 5 main topics of feedback were dietary information, compliments, consolation, automatic bot feedback, and health information. The feedback topic distribution significantly differed depending on the type of EE behavior (overall P<.001).

Conclusions
This study introduces a data-driven approach for analyzing behavior patterns of social website users with EE behaviors. We discovered the possibility of the LDA topic model as an exploratory user study method for abnormal behaviors in medical research. We also investigated the possibilities of ML- and topic modeling–based classifiers to automatically categorize text-based behavioral data, which could be applied to personalized medicine in future research.
Patient Use and Experience With Online Access to Electronic Health Records in Norway: Results From an Online Survey
Authors: Zanaboni Paolo , Kummervold Per Egil , Sørensen Tove , Johansen Monika Alise 
Published: December 2019

Background
The electronic health record (EHR) has been fully established in all Norwegian hospitals. Patient-accessible electronic health records (PAEHRs) are available to citizens aged 16 years and older through the national health portal Helsenorge.

Objective
This study aimed at understanding how patients use PAEHRs. Three research questions were addressed in order to explore (1) characteristics of users, (2) patients’ use of the service, and (3) patient experience with the service.

Methods
We conducted an online survey of users who had accessed their EHR online at least once through the national health portal. Patients from two of the four health regions in Norway were invited to participate. Quantitative data were supplemented by qualitative information.

Results
A total of 1037 respondents participated in the survey, most of whom used the PAEHR regularly (305/1037, 29.4%) or when necessary (303/1037, 29.2%). Service utilization was associated with self-reported health, age, gender, education, and health care professional background. Patients found the service useful to look up health information (687/778, 88.3%), keep track of their treatment (684/778, 87.9%), prepare for a hospital appointment (498/778, 64.0%), and share documents with their general practitioner (292/778, 37.5%) or family (194/778, 24.9%). Most users found it easy to access their EHR online (965/1037, 93.1%) and did not encounter technical challenges. The vast majority of respondents (643/755, 85.2%) understood the content, despite over half of them acknowledging some difficulties with medical terms or phrases. The overall satisfaction with the service was very high (700/755, 92.7%). Clinical advantages to the patients included enhanced knowledge of their health condition (565/691, 81.8%), easier control over their health status (685/740, 92.6%), better self-care (571/653, 87.4%), greater empowerment (493/674, 73.1%), easier communication with health care providers (493/618, 79.8%), and increased security (655/730, 89.7%). Patients with complex, long-term or chronic conditions seemed to benefit the most. PAEHRs were described as useful, informative, effective, helpful, easy, practical, and safe.

Conclusions
PAEHRs in Norway are becoming a mature service and are perceived as useful by patients. Future studies should include experimental designs focused on specific populations or chronic conditions that are more likely to achieve clinically meaningful benefits. Continuous evaluation programs should be conducted to assess implementation and changes of wide-scale routine services over time.
THE ONLINE SHOPPING HABITS AND E-LOYALTY OF GEN Z AS NATIVES IN THE DIGITAL ERA
Authors: Ayuni Risca Fitri 
Published: December 2019

Introduction: Generation Z (Gen Z) refers to the most application-friendly and website-savvy generation engaging with the Internet for most of its daily activities. The number of Gen Z members has been growing and is projected to become the largest market segment by 2020. In the future, Gen Z will affect business strategies; compounded by the presence of a fourth industrial revolution (Industry 4.0), which will encourage companies to change their business models. One of the changes is a new paradigm shift by companies from the traditional business model to an internet-based business model (e-business model/e-commerce), such as online shops. Online shops have escalated at a rapid pace and have changed people’s buying habits, especially for Gen Z. Gen Z seems to be shopping online more than ever. Targeting them is the best strategy to enhance their lifetime loyalty. Background Problem: This study aims to examine the relationship of e-service quality, online customer value, e-satisfaction and e-loyalty. Research Method: Two hundred and forty-one Gen Z respondents were involved in this study. PLS 3, Sobel and SPSS 23 were employed to analyze the data. Five hypotheses were proposed. Findings: The findings indicated that e-service quality became the expected predictor of online customer value and satisfaction. In addition, the results confirm the mediating role of online customer value between e-service quality and e-satisfaction, as well as clarifying the relationship of online customer value and e-satisfaction. Finally, the effect of e-satisfaction on e-loyalty has been proven in this study. Conclusion: Upon figuring out the relevant issue, online shops are able to re-consider their business models to adopt the Industry 4.0 revolution, to strengthen their capacity in tight competition. In order to target Gen Z, who mostly do their purchasing via the Internet, online shops must provide high quality websites and create values which convey economic, social and functional values. These two key factors play significant roles in attaining Gen Z’s e-satisfaction, thus securing Gen Z’s e-loyalty.
EFFICACY AND SAFETY OF TENELIGLIPTIN AS ADD-ON THERAPY TO CONVENTIONAL THERAPY IN INDIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: PARMAR VINENDRA M  , GOSWAMI SUNITA S  
Published: December 2019

Objective: Teneligliptin is a novel, highly selective dipeptidyl peptidase-4 inhibitor. The objective of the present study was to investigate the efficacy and safety of teneligliptin as add-on therapy in patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled by conventional therapy (metformin/glimepiride) in India.
Methods: Clinical study protocol was approved by the Institutional Ethics Committee. T2DM patients (male/female) whose glycated hemoglobin (HbA1c) >7% were randomized to receive following group treatments, namely, Treatment A: Metformin/glimepiride plus add-on teneligliptin 20 mg and Treatment B: Metformin/glimepiride for 24 weeks. A pre-designed case report form was used to collect information from the prescribing physicians regarding the efficacy and safety of teneligliptin. Efficacy variables included change in plasma blood glucose (fasting and postprandial) and HbA1c from baseline to week 24. Treatment emergent adverse events were assessed.
Results: A total of 120 type 2 diabetes patients were analyzed. Teneligliptin as add-on therapy with metformin/glimepiride significantly reduced plasma glucose (HbA1c, fasting, and postprandial) concentration as compared to conventional therapy.
Conclusion: Add-on therapy with teneligliptin was found superior over conventional therapy in reducing plasma glucose concentration (fasting and postprandial) and HbA1c levels significantly in patients with T2DM. Further, it was found effective and well tolerated in Indian patients with T2DM who are inadequately controlled with conventional therapy.
KNOWLEDGE AND PERCEPTIONS OF VITAMIN D DEFICIENCY AMONG THE UNITED ARAB EMIRATES POPULATION
Authors: OSAMA MOHAMED IBRAHIM  , NOOR KIFAH AL-TAMEEMI  , DALIA DAWOUD  
Published: December 2019

Objectives: The purpose of this study is to assess the Vitamin D deficiency awareness and perceptions between the United Arab Emirates (UAE) population.
Methods: A cross-sectional study was done among the population of two emirates at the UAE: Abu Dhabi and Sharjah.
Results: Overall, 434 participants completed the survey. Majority of people were aware of phenomenon of Vitamin D deficiency, but only 21.4% of them knew that sunlight is considered the main source of Vitamin D. Moreover, less than half of participants check their Vitamin D blood level regularly and around 55% of them follow-up with their physicians after completing the treatment. High proportion of participant females spend <1 h outdoors (60%) and use sunscreen daily (55%) that cause higher prevalence of Vitamin D deficiency among females than males (83% vs. 42%).
Conclusion: This research gives some insights regarding the UAE population’s awareness and perceptions of Vitamin D insufficiency. Decreased awareness of sunlight exposure as a major source of Vitamin D, in addition to lifestyle, contributed to Vitamin D deficiency problem among the UAE population, in general, and in females, in particular.
PREPARATION AND EVALUATION OF IBUPROFEN EFFERVESCENT GRANULES
Authors: JUTI RANI DEVI  , BIDYUT DAS  
Published: December 2019

Objectives: The aim of the present investigation is to prepare the effervescent granules of different formulations and evaluated for different parameters including drug release study.
Methods: The effervescent granules of five different formulations such as F1, F2, F3, F4, and F5 were prepared by the wet granulation method using different concentration of excipients including sodium bicarbonate and potassium bicarbonate. The prepared formulations were evaluated for different parameters including effervescent time as well as drug release study.
Results: After evaluating all the parameters, it has been found that the formulation F5 shows better drug release among all the formulation and least effervescent time. Where it can conclude that as the effervescent time is less, i.e., it quickly bursts and shows its effect quickly. Lesser the bursting time quicker the drug release.
Determination of Minimum Inhibitory Concentration (MIC) and percentage Bacterial Growth Inhibition of essential oils against Gram Positive Bacterial pathogens
Authors: Nagalakshmi S. , Saranraj P. , Sivasakthivelan P. 
Published: December 2019

Essential oils and volatile constituents extracted from Aromatic plants are frequently used in folk medicine for prevention and treatment of different human diseases. The urge to develop alternative treatment strategies follows three different directions. In the present study, an attempt has been planned to determine the Minimum Inhibitory Concentration (MIC) and Percentage Growth Inhibition of Essential oils against two Gram positive bacterial pathogens, Staphylococcus aureus and Bacillus subtilis. The Essential oils selected for the present study was collected from Sidha Medicine Shop, Tirupattur, Vellore district, Tamil Nadu, India. The Broth dilution method was used for the determination of Minimum Inhibitory Concentration (MIC) of Essential oils. The Minimum Inhibitory Concentration (MIC) studies were conducted by using various concentrations of Essential oils viz., 25 µl/ml, 50 µl/ml, 75 µl/ml and 100 µ/ml. The Essential oils exhibits inhibitory activity against Gram positive bacteria in all the concentrations. Among the seven Essential oils tested, Mahualongif oil has showed maximum percentage bacterial growth inhibition when compared to other Essential oils. The inhibitory activity of Mahualongif oil was observed more in Staphylococcus aureus when compared to Bacillus subtilis. For Staphylococcus aureus, lowest inhibitory percentage was noticed in Pungam oil and for Bacillus subtilis lowest inhibitory percentage was noticed in Coconut oil.
Keywords: Essential oils, Minimum inhibitory concentration (MIC), Percentage bacterial growth inhibition, Bacillus subtilis and Staphylococcus aureus.
Antimicrobial activity of Plectranthus amboinicus solvent extracts against Human Pathogenic Bacteria and Fungi
Authors: Sivaranjani D. , Saranraj P. , Manigandan M. , Amala K. 
Published: December 2019

Plectranthus amboinicus or locally known as bangun-bangun, is an indigenous vegetable which can be freshly eaten. However, the plant is unpopular among local people and being neglected. It has been reported to be traditionally used for medicine to cure common illnesses such as cough, stomachache, headache and skin infection. Based on the potential, a study was conducted to bioprospect the antimicrobial activity of the essential oil. Plectranthus amboinicus essential oil of methanol and chloroform extract was tested against nine bacteria and four fungi i.e., Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Shigella flexneri, Klebsiella pneumoniae, Enterococcus faecal, Staphylococcus aureus, Salmonella typhi, Bacillus cereus, Candida albicans, Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus. The methanol extract of Plectranthus amboinicus showed the maximum antibacterial activity against the bacteria Klebsiella pneumoniae and fungi Candida albicans. The antimicrobial activity of Plectranthus amboinicus was more at 100 mg/ml concentration when compared to 50 mg/ml concentration. Comparatively, the Methanol extract of Plectranthus amboinicus exhibited maximum antimicrobial activity when compared to Chloroform extract. The Plectranthus amboinicus has showed good antimicrobial activity against most of the bacteria and only one fungal yeast Candida albicans. No zone of inhibition was recorded against other fungal isolates like Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Negative DMSO control.
Keywords: Plectranthus amboinicus, Bacteria, Fungi, Antimicrobial activity and Well diffusion assay.
Characterization and phylogenetic analysis of alkaline α-amylase producing Brevibacillus laterosporus from mountain climatic zone of India
Authors: Nair Girish R , Raja Suresh S.S. 
Published: December 2019

α-amylases (EC3.2.1.1) are glycoside hydrolases that breakdown complex starch and maltodextrins into glucose and maltose by acting upon 1,4-glycosidiclinkages. Several amylases have been isolated and purified from members of Bacillus community, which find extensive application in starch processing, textile and pharmaceutical industry. Keeping this in mind we isolated α-amylase producing gram positive bacterium from soils collected from mountain climatic zone of India and identified it as Brevibacillus laterosporus. We further studied the effect of temperature and pH on the amylase activity of this strain and found a very stable activity at alkaline pH of 10 and temperature of 45 ºC. To our knowledge this a first report on characterization and evolutionary analysis of alkaline α-amylase producing Brevibacillus laterosporus isolated from unexplored sites of mountain climatic zone of India.
Keywords: Climatic zone, Brevibacillus, Amylase, 16S rRNA gene sequencing, Phylogenetic analysis