bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in hysterectomy‐corrected uterine cancer mortality rates during 2002 to 2015: mortality of nonendometrioid cancer on the rise?
Authors: Gustafson Line W. , Booth Berit B. , Kahlert Johnny , Ørtoft Gitte , Mejlgaard Else , Clarke Megan A. , Wentzensen Nicolas , Rositch Anne F. , Hammer Anne 
Published: July 2020

AbstractCorpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy‐corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage and histologic subtype. Using data from nationwide Danish registries, we calculated uncorrected and hysterectomy‐corrected age‐standardized mortality rates of corpus uteri cancer among women ≥35 years during 2002 to 2015. Individual‐level hysterectomy status was obtained from national registries; hysterectomy‐corrected mortality rates were calculated by subtracting posthysterectomy person‐years from the denominator, unless hysterectomy was performed due to corpus uteri cancer. Correction for hysterectomy resulted in a 25.5% higher mortality rate (12.3/100000 person‐years vs 9.8/100000 person‐years). Mortality rates were highest in women aged 70+, irrespective of year of death, histologic subtype and stage. A significant decline was observed in overall hysterectomy‐corrected mortality rates from 2002 to 2015, particularly among women aged 70+. Mortality rates of endometrioid cancer declined significantly over time (annual percent change [APC]: −2.32, 95% CI −3.9, −0.7, P = .01), whereas rates of nonendometrioid cancer increased (APC: 5.90, 95% CI: 3.0, 8.9, P < .001). With respect to stage, mortality rates increased significantly over time for FIGOI‐IIa (APC: 6.18 [95% CI: 1.9, 10.7] P = .01) but remained unchanged for FIGO IIb‐IV. In conclusion, increasing mortality rates of nonendometrioid cancer paralleled the previously observed rise in incidence rates of this histologic subtype. Given the poor prognosis of nonendometrioid cancer, more studies are needed to clarify the underlying reason for these findings.
A chemical conjugation of JQ‐1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation
Authors: Wang Xiaodong , Yu Bingying , Cao Birong , Zhou Ji , Deng Yongqiang , Wang Zhulin , Jin Guangyi 
Published: July 2020

AbstractIn recent years, inhibitors of the BET bromodomain proteins, such as BRD4 inhibitors, have demonstrated robust antitumor activity. JQ‐1, a representative small molecular BRD4 inhibitor, is also effective to block PD‐1/PD‐L1 signaling by significantly decreasing the PD‐L1 expression on tumor cells. However, toxicity of BRD4 inhibitors on lymphoid and hematopoietic tissues limits their clinical usage. In this research, we designed and studied an immunogenic BRD4 inhibitor, SZU‐119, by coupling JQ‐1 with a TLR7 agonist, SZU‐101. In vitro, SZU‐119 stimulated the production of cytokines in mouse BMDCs and spleen lymphocytes, and inhibited the expression of PD‐L1 in mouse B16 tumor cells. In vivo, SZU‐119 suppressed the B16 tumor growth at both injected and uninjected sites, and prolonged the survival time of mice. SZU‐119 elevated the number of total CD8+ and IFN‐γ+ CD8+ T cells in spleens, with greater CTL cytotoxicity to B16 tumor cells. It was also observed that the infiltration of CD8+ T cells was increased in tumors at both local and distant sites, and the PD‐L1 expression was decreased in tumor cells at the primary site. In conclusion, we have demonstrated that SZU‐119 activated the innate immune cells, kept efficacy of PD‐L1 blockade and abrogated immune toxicity, showing more potent antitumor effects than the simple mixture of SZU‐101 and JQ‐1 in a mouse melanoma model. Our work provides new insights for the development of anti‐melanoma drugs that concurrently target innate and adaptive immunity.
Use of cancer data for cancer control in the Eastern Mediterranean Region: Results of a survey among population‐based cancer registries
Authors: Znaor Ariana , Fouad Heba , Majnoni d'Intignano Fosca , Hammerich Asmus , Slama Slim , Pourghazian Nasim , Eser Sultan , Piñeros Petersen Marion , Bray Freddie 
Published: July 2020

AbstractData from population‐based cancer registries (PBCR) are critical for planning, monitoring and evaluation of cancer control programs, but are frequently underutilized by key stakeholders. As part of the ongoing partnership of the International Agency for Research on Cancer (IARC) and the WHO Eastern Mediterranean Regional Office (EMRO) in cancer surveillance, we designed a cancer registry survey to assess the level of involvement of PBCR in national cancer control planning across the region. A questionnaire on registry characteristics, their contribution to cancer control and perceived barriers, was sent to 14 countries with operational PBCR. We obtained replies from Bahrain, Egypt, Iraq, Iran, Jordan, Kuwait, Lebanon, Morocco, Oman, Qatar, Saudi Arabia, Tunisia and the United Arab Emirates. We found a high participation of PBCR in cancer control planning (all registries involved, 46% routinely) and the evaluation of screening (92% registries involved, 46% routinely), but a much lower level of participation in palliative care and rehabilitation activities. Specified barriers included poor governance, a lack of awareness by policy makers, insufficient resources and a limited availability of data electronically, including mortality data. Appropriate planning to ensure the sustainability of PBCR (including the employment of permanent staff), increasing training, building research capacity and ensuring an efficient provision of high‐quality data to policymakers, were among the proposed solutions. The results of our study reinforce the need for further tailoring of activities in support of cancer registration and enhanced networking among stakeholders, toward improving quality and use of cancer registry data for cancer control in the EMR.
Synchronisation of policy related uncertainty, financial stress and economic activity in the United States
Authors: Tiwari Aviral Kumar , Nasir Muhammad Ali , Shahbaz Muhammad 
Published: July 2020

AbstractThis study analyses the synchronisation of economic activity, financial stress and uncertainty in the United States by employing a wavelet‐based approach of cohesion. Being innovative in the choice of the methodological framework as well as underlying factors of interest, we employed the monthly data on the policy‐related uncertainty indexes, Chicago Fed National Activity Index (CFNAI) and Kansas City Federal Reserve Financial Stress Index (KCFSI). Our key empirical findings suggest that the co‐movements of policy uncertainty, financial stress and economic activity are frequencies as well as time‐dependent. The uncertainty indices are found to be synchronised at lower and intermediate frequencies for all of the pairs. In the nexus between uncertainty and economic activity, financial stress plays a crucial role. Co‐movement of the policy uncertainty is observed to be more pronounced during the crisis periods though at different frequencies which indicated the usefulness of the proposed framework to analyse the implications of contemporaneous policy uncertainty and financial stress for the real economy. Concomitantly this informs the policy efforts to address the financial and economic instabilities which may arise as a consequence of financial stress and policy uncertainty.
Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey
Authors: Schuhladen Katharina , Raghu Swathi N. V. , Liverani Liliana , Neščáková Zuzana , Boccaccini Aldo R. 
Published: July 2020

AbstractWound dressings produced by electrospinning exhibit a fibrous structure close to the one of the extracellular matrix of the skin. In this article, electrospinning was used to fabricate fiber mats based on the well‐known biopolymers poly(ɛ‐caprolactone) (PCL) and methylcellulose (MC) using benign solvents. The blend fiber mats were cross‐linked using Manuka honey and additionally used as a biodegradable platform to deliver bioactive glass particles. It was hypothesized that a dual therapeutic effect can be achieved by combining Manuka honey and bioactive glass. Morphological and chemical examinations confirmed the successful production of submicrometric PCL‐MC fiber mats containing Manuka honey and bioactive glass particles. The multifunctional fiber mats exhibited improved wettability and suitable mechanical properties (ultimate tensile strength of 3–5 MPa). By performing dissolution tests using simulated body fluid, the improved bioactivity of the fiber mats by the addition of bioactive glass was confirmed. Additionally, cell biology tests using human dermal fibroblasts and human keratinocytes‐like HaCaT cells showed the potential of the fabricated composite fiber mats to be used as wound dressing, specially due to the ability to support wound closure influenced by the presence of bioactive glass. Moreover, based on the results of the antibacterial tests, it is apparent that an optimization of the electrospun fiber mats is required to develop suitable wound dressing for the treatment of infected wounds.
MRP8/14 mediates macrophage efferocytosis through RAGE and Gas6/MFG‐E8, and induces polarization via TLR4‐dependent pathway
Authors: Li Kangxin , Chen Guiming , Luo Haihua , Li Jianhang , Liu Aihua , Yang Chen , Wang Juan , Xu Jia , Gao Shenghan , Chen Peng , Jiang Yong 
Published: July 2020

AbstractMyeloid‐related protein 8/14 (MRP8/14) participates in various inflammatory responses, however, its effect on macrophage efferocytosis remains unclear. Here, we demonstrate that MRP8/14 significantly inhibits the efferocytosis of apoptotic thymocytes by mouse bone marrow‐derived macrophages (BMDMs), which later proves to be associated with the receptor for advanced glycation end products (RAGE) or for reducing the expression of growth arrest‐specific protein 6 and milk fat globule epidermal growth factor 8, independent of RAGE. Furthermore, MRP8/14 promotes polarization of BMDMs from the M2‐ to M1‐like phenotype by upregulating expression of M1‐related surface receptor proteins and signature M1‐marker genes and by downregulating signature M2‐marker gene expression, which depends on Toll‐like receptor 4 and p38 mitogen‐activated protein kinase/nuclear factor κB pathways. Thus, we report a significant inhibitory effect of MRP8/14 on macrophage efferocytosis and MRP8/14‐mediated phenotypic polarization, which may be helpful in developing novel therapeutic strategies leading to inflammation resolution.
Recent advances of the function of sphingosine 1‐phosphate (S1P) receptor S1P3
Authors: Fan Xuehui , Liu Lili , Shi Yue , Guo Fanghan , He Xiao , Zhao Xiuli , Zhong Di , Li Guozhong 
Published: July 2020

AbstractKnown as a variety of sphingolipid metabolites capable of performing various biological activities, sphingosine 1‐phosphate (S1P) is commonly found in platelets, red blood cells, neutrophils, lymph fluid, and blood, as well as other cells and body fluids. S1P comprises five receptors, namely, S1P1–S1P5, with the distribution of S1P receptors exhibiting tissue selectivity to some degree. S1P1, S1P2, and S1P3 are extensively expressed in a wide variety of different tissues. The expression of S1P4 is restricted to lymphoid and hematopoietic tissues, while S1P5 is primarily expressed in the nervous system. S1P3 plays an essential role in the pathophysiological processes related to inflammation, cell proliferation, cell migration, tumor invasion and metastasis, ischemia‐reperfusion, tissue fibrosis, and vascular tone. In this paper, the relevant mechanism in the role of S1P3 is summarized.
Early‐life stress affects behavioral and neurochemical parameters differently in male and female juvenile Wistar rats
Authors: Noschang C. , Krolow R. , Arcego D. M. , Marcolin M. , Ferreira A. G. , da Cunha A. A. , Wyse A. T. S. , Dalmaz C. 
Published: July 2020

AbstractNeonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex‐specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1–10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole‐board task, increased Na+/K+‐ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non‐handled males. Female neonatal handled animals increased the number of rearing and nose‐pokes on the hole‐board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non‐handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex‐specific manner even before the puberty onset.
Synthesis and antitumor activity of some nitrogen heterocycles bearing pyrimidine moiety
Authors: Ahmed Marwa H. , El‐Hashash Maher A. , Marzouk Magda I. , El‐Naggar Abeer M. 
Published: July 2020

AbstractSynthesis of novel pyrimidine derivatives 4‐16 was accomplished by heterocyclization of polarized system, for example, Chalcone. Claisen‐Schmidt condensation of 2‐acetyl naphthalene with 4‐(N, N‐dimethylaminobenzaldehyde) afforded chalcone 3, which was utilized for synthesis various pyrimidine derivatives by treatment with urea, thiourea, and guandine hydrochloride in ethanolic sodium hydroxide solution. The reactivity of the synthesized pyrimidine derivatives towards different nucleophilic and electrophilic reagent were examined. The constructions of the newly synthesized pyrimidine derivatives were elucidated from their spectral and elemental analysis. All the synthesized compounds were tested in vitro for their anticancer activities against HePG‐2 and MCF‐7 cell lines. Some of them posses a wide range of pharmacological activity. Finally, a molecular docking study was conducted to reveal the probable interaction with the dihydrofolate reductase (DHFR) active site.
Sucrose replacement: a sensory profile and time‐intensity analysis of a tamarind functional beverage with artificial and natural non‐nutritive sweeteners
Authors: Sousa Lima Rafael , Cazelatto de Medeiros Alessandra , André Bolini Helena Maria 
Published: July 2020

AbstractBACKGROUNDTamarind pulp contains polyphenolic compounds that exert antioxidant and anti‐inflammatory effects with a positive impact on human health. The elaboration of a tamarind‐based functional beverage, without the addition of sucrose, can be an alternative to traditional caloric beverages. This study aimed to evaluate the sensory profile and time intensity of a functional tamarind beverage containing artificial and natural non‐nutritive sweeteners.RESULTSThe results of the acceptance test, check‐all‐that‐apply, and time‐intensity tests showed that there were no statistically significant differences between the means of samples sweetened with sucralose and samples sweetened with sucrose for attributes relating to appearance, aroma, flavor, or texture, or for overall impression. Samples with natural sweeteners had lower means for overall product impression and a lower percentage of purchase intention. The perception of astringency, bitter taste, and bitter aftertaste may be linked to the lower global impression of the product. The descriptors ‘tamarind flavor’ and ‘refreshment sensation’ were higher in products that were more liked. The sample sweetened with stevia showed higher levels of sweetness, bitterness, and longer sweet stimulus duration in the time‐intensity test.CONCLUSIONThe sample sweetened with sucralose was the best alternative to sucrose in the functional tamarind beverage. The analyzed sweeteners did not show changes in the perception of the natural characteristics of the fruit used, such as tamarind flavor, refreshment sensation, and astringency. However, the attributes related to sweet and bitter aftertaste experienced in samples with natural sweeteners may have influenced the reduction in the intention to purchase the product. © 2020 Society of Chemical Industry
Chlorogenic acid ameliorates obesity by preventing energy balance shift in high‐fat diet induced obese mice
Authors: He Xiaoyun , Zheng Shujuan , Sheng Yao , Miao Tong , Xu Jia , Xu Wentao , Huang Kunlun , Zhao Changhui 
Published: July 2020

AbstractBACKGROUNDChlorogenic acid is a type of phenolic acid found in many plants. Chlorogenic acid has an anti‐obesity effect with an unclear mechanism. The present study aimed to investigate the regulatory effect of chlorogenic acid on energy balance in high‐fat diet (HFD) induced obese C57BL/6J mice administrated 100 mg kg–1 chlorogenic acid for 13 weeks.RESULTSThe consumption of chlorogenic acid ameliorated HFD induced obesity. Chlorogenic acid did not change the physical activity but significantly decreased food intake and increased body temperature, thermal dissipation and brown adipose tissue activity. Moreover, chlorogenic acid improved glucose tolerance but had a moderate impact on other blood indices. Additionally, chlorogenic acid failed to restore the microbiota change associated with HFD induced obesity, but modified the gut bacterial composition in a unique way.CONCLUSIONSupplementation with chlorogenic acid can improve HFD induced obesity and associated glucose intolerance mainly via regulating food intake and energy expenditure. © 2020 Society of Chemical Industry
Continuing surgical care in cancer patients during the nationwide lockdown in the COVID‐19 pandemic—Perioperative outcomes from a tertiary care cancer center in India
Authors: Pai Esha , Chopra Saumya , Mandloi Deepak , Upadhyay Arvind K. , Prem Amar , Pandey Durgatosh 
Published: July 2020

AbstractBackgroundThe coronavirus disease‐2019 (COVID‐19) pandemic has disrupted management of non‐COVID‐19 illnesses, including cancer. For many solid organ cancers, surgical intervention is imperative. We present our experience with major operations during a nationwide lockdown.MethodThis was an observational study of 184 patients, analyzing their perioperative outcomes and categorizing morbidity according to Clavien‐Dindo Classification. Strict screening required symptomatic patients to be referred to COVID centers and their operations postponed. Continuous and categorical variables were expressed as medians with range and frequencies and percentages, respectively. A two‐sided α < .05 was statistically significant.ResultsDuring the lockdown, we initiated a graded response over four phases: (I) 24 March to 14 April (18 procedures); (II) 15 April to 3 May (26 procedures); (III) 4 to 17 May (41 procedures); and (IV) 18 to 31 May (99 procedures). The rates of major perioperative morbidity were 10.9% and mortality 1.6%. Over the four phases, the major morbidity rates were 11.1%, 15.4%, 9.8%, and 13.1%. On multivariate analysis, an emergency procedure was the only significant factor associated with morbidity. During the study period, no hospital staff became symptomatic for COVID‐19.ConclusionIn a region with milder impact of COVID‐19, treatment of cancer patients need not be deferred. Our study showed that with appropriate precautions, asymptomatic patients may undergo operations without increased morbidity to them and hospital staff.
Soil aggregation accounts for the mineral soil organic carbon and nitrogen accrual in broadleaved forests as compared to that of coniferous forests in Northeast China: Cross‐sites and multiple species comparisons
Authors: Wei Chenhui , Wang Qiong , Ren Manli , Pei Zhongxue , Lu Jiali , Wang Huimei , Wang Wenjie 
Published: July 2020

AbstractDifferences in soil organic carbon (SOC) and total nitrogen (TN) between broadleaved and coniferous forests are not well‐defined, hindering the evaluation of the influence of forest‐type on land degradation and development. For these two foresttypes, we determined differences in soil aggregation, SOC, and TN by comparing 202 plots at six sites with 14 common afforestation tree species. Bulk soil was separated to macroaggregates (0.25–2 mm), microaggregates (0.053–0.25 mm), and silt and clay fractions (<0.053 mm). Inter‐site variations were excluded by MANOVA (multiple analysis of variance) and MANCOVA (multiple analysis of covariance). Broadleaved forests exhibited 30–50% higher SOC and TN in bulk soils than that of coniferous forests, and aggregates contributed to 75–77% of the SOC and TN accrual. The high accrual was a result of SOC and TN concentration increases in aggregates (30–50%), macroaggregates fraction increases (50%, with a 14% decrease in the non‐aggregate fractions), aggregates diameter increases (one‐third), and non‐significant differences in C/N. Uncertainty tests showed a low bias (4.2%), and the accrual of SOC and TN in broadleaved forests were larger at sites with less clay and at higher altitude and more precipitation and afforested with more fraxinus and less poplar. Our results highlight that SOC and TN accrual in broadleaved forests is mainly due to the stronger aggregates protection, which should be fully considered during precise land evaluation and species selection for afforestation. Future studies identifying the mechanisms underlying these changes should consider interactions among leaf functional traits, aggregation‐disaggregation processes, and microbial rhizosphere deposition.
Effects of carbon‐based materials and redmuds on metal(loid) immobilization and growth of Salix dasyclados Wimm. on a former mine Technosol contaminated by arsenic and lead
Authors: Lebrun Manhattan , Van Poucke Reinhart , Miard Florie , Scippa Gabriella S. , Bourgerie Sylvain , Morabito Domenico , Tack Filip M. G. 
Published: July 2020

AbstractMetal(loid) soil contamination is a widespread issue and its remediation a priority. Phytoremediation involves the use of plants to stabilize/extract metal(loid)s and prevent spreading of contaminants. Salicaceae are fast growing trees that can tolerate and accumulate metal(loid)s. Amendments may be needed to facilitate plant growth on the contaminated substrate. Biochar, the solid product of pyrolysis, can ameliorate soil properties and reduce metal(loid) bioavailability but showed low affinity toward arsenic. Redmud, a waste product, can immobilize arsenic and other metal(loid)s and improve soil conditions. To evaluate the potential of those amendments to immobilize metal(loid)s and facilitate the establishment of a cover vegetation with willow (Salix dasyclados Wimm.), a pot experiment was conducted using several carbon‐based materials (biochar and activated carbon) and redmuds. Two carbon‐based materials and two redmuds were selected for the pot experiment based on characteristics and sorption tests. A former mining soil was amended with these products and Salix dasyclados cuttings were planted. Biochar and one redmud improved growth of Salix dasyclados Wimm. Redmud, which is cheaper than biochar, performed equally well as the biochar at a lower application rate. It can therefore be concluded that the application of redmud, associated to Salix dasyclados, could be an option for the phytoremediation of an As and Pb contaminated soil. However, these results need to be evaluated on a bigger scale to assess the gain brought by the combination of redmud and Salix dasyclados on the contaminated area.