bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKE (FOOT AND ANKLE EXERCISES) UNTUK PENCEGAHAN KOMPLIKASI PADA KAKI PENDERITA DIABETES MELLITUS DI SURABAYA
Authors: Pratiwi Ika Nur , Ni'mah Lailatun , Widyawati Ika Yuni , Dwi Lingga Curnia 
Published: June 2020

Pendahuluan: Salah satu komplikasi penyakit diabetes melitus (DM) yang sering dijumpai adalah kaki diabetik (diabetic foot), yang dapat ber- manifestasikan sebagai ulkus, infeksi dan gangren dan artropati Charcot. Ada dua tindakan dalam prinsip dasar pengelolaan diabetic foot yaitu tindakan pencegahan dan tindakan rehabilitasi. Tindakan pencegahan meliputi edukasi perawatan kaki, sepatu diabetes dan senam kaki (Yudhi, 2009). Fake (Foot and Ankle Exercises) atau dikenal juga dengan senam kaki merupakan latihan yang dilakukan bagi penderita DM atau bukan penderita untuk mencegah terjadinya luka dan membantu melancarkan peredaran darah bagian kaki (Soebagio, 2011). Melakukan perawatan kaki secara teratur dapat mengurangi penyakit kaki diabetik sebesar 50-60%. Untuk meningkatkan vaskularisasi perawatan kaki dapat juga dilakukan dengan gerakan-gerakan kaki yang dikenal sebagai senam kaki diabetes (Black & Hawks, 2009; Smeltzer et al., 2010; Lewis et al., 2011). Puskesmas Klampis Ngasem memiliki jumlah kunjungan pasien dengan diabetes mellitus yang cukup tinggi di Surabaya. Berdasarakan data dari Puskesmas Klampis Ngasem dalam kurun waktu Januari-September 2017 jumlah kunjungan pasien dengan DM mencapai 2219 kasus.Metode: Wilayah Kerja Puskesmas yang akan menjadi tempat pengabdian masyarakat ini adalah Puskesmas Klampis Ngasem Surabaya. Metode yang digunakan melalui pendidikan dan pelatihan senam kaki “Fake” (Foot and Ankle Exercises) sebagai upaya pencegahan terhadap komplikasi pada kaki penderita Diabetes Mellitus Di Puskesmas Klampis Ngasem Surabaya sebanyak 30 orang pasien dengan DM. Peserta pengmas akan dilakukan kegiatan pre-test dan post-test dengan mengisi kuesioner pengetahuan dan kemampuan perawatan kaki pada penderita diabetes serta dilakukan pengukuran sirkulasi darah sebelum dan sesudah kegiatan menggunakan tensimeter di lengan dan kaki hingga diperoleh tekanan sistolik lengan dan kaki untuk pemeriksaan ankle brachial index (ABI).Hasil: Evaluasi Akhir Program Pengabdian Kepada Masyarakat diperoleh bahwa pengetahuan penderita DM terhadap perawatan kaki yang menunjukkan peningkatan nilai rerata post test menjadi 70 dari nilai rerata pada pre test 49 terhadap 30 peserta DM. Sementara itu, didapatkan 18 orang memiliki skor ABI dengan interpretasi borderline perfusion (0,6-0,8) dan sisanya berada dalam rentang normal. Sedangkan setelah dilakukan latihan jasmani berupa senam kaki didapatkan 6 orang masih memiliki skor ABI rentang 0,6-0,8 dengan interpretasi borderline perfusion dan 24 orang berada dalam rentang normal dengan skor ABI 0,9-1,3. Kesimpulan: Diharapkan informasi yang telah disampaikan dalam modul dapat dijadikan panduan dalam memantau penatalaksanaan perawatan kaki pada diabetes mellitus serta Kegiatan senam kaki ini dapat dilakukan secara teratur dirumah dan gerakannya disesuaikan dengan kemampuan tubuh.
PENGARUH MODIFIKASI STANDAR MAKANAN NON DIET TERHADAP BIAYA MAKAN YANG TERBUANG PADA PASIEN GERIATRI KELAS III DI RSUP dr. SOERADJI TIRTONEGORO KLATEN
Authors: Lestari Mawar Mawar , Agustia Friska Citra , Betaditya Dika 
Published: June 2020

THE EFFECT OF NON-DIET FOOD STANDARDS MODIFICATION ON WASTED FOOD COSTS IN CLASS III GERIATRIC PATIENTS AT RSUP dr. SOERADJI TIRTONEGORO KLATEN
ABSTRACT
Background: Decreasing food intake in geriatric patients due to physical and psychological conditions has an impact on the high percentage of food plate waste and wasted food costs. This study aims to determine the effect of non-diet food standards modification on the cost of food wasted on class III geriatric patients at RSUP dr. Soeradji Tirtonegoro Klaten.
Methods: This experimental study used a post test only with control group design. The sample consisted of 34 people divided into 2 groups, the treatment group that received food standard modification and the control group that received food according to hospital standards. The food plate waste of each group was observed for 2 days using the Comstock visual estimation method. Wasted food costs were calculated by multiplying the percentage of food plate waste per menu item with food prices. The effect of non-diet food standards modification on wasted food costs was analyzed using the Mann Whitney test with a confidence degree of 95% (α = 0.05)
Results: The average wasted food cost in the treatment group was Rp 2.806,34 and the control group was Rp 3.443,43. The results of the analysis of the effect of non-diet food standards modification on wasted food cost by the Mann Whitney test showed a p-value of 0.109 (> 0.05)
Conclusion: There is no significant effect of non-diet food standards modification on wasted food costs in class III geriatric patients at RSUP dr. Soeradji Tirtonegoro Klaten.
Assessment of Availability and Use of Teaching and Learning Resources for Retention of Learners with Special Needs in Regular Primary Schools in Dadaab Sub-County, Kenya
Authors: Osman Dure Mohammed , P. A. Oracha , Joel Okutoyi 
Published: June 2020

The status of implementation of inclusive education in terms of availability and use of teaching and learning resources for retention of learners with special needs in Garissa County was unknown. Inclusive education refers to a situation where learners with disabilities and special educational needs have full membership in age-appropriate classes in their regular neighborhood schools with appropriate supplementary aids and support services. Records from Educational Assessment and Resource Centres (EARC) Garissa County revealed that there was a decline in the retention rate of learners` admitted. For example, in the year 2014, the retention rate was 37 learners (45.7%), 2015 (114 learners, 38.0%), 2016 (43 learners, 28.9%), 2017 (35 learners, 31.5%) and 2018 (41 learners, 23.7%). The purpose of the study was to assess the status of implementation of inclusive education practices for the retention of learners with special needs in regular primary schools in Dadaab sub-county. The specific objective of the study was to establish the extent to which the availability and use of teaching and learning resources affect the retention of learners with special needs in regular primary schools in Dadaab sub-county. The study adopted a descriptive survey research design. The target population comprised 26 head-teachers, 78 teachers, 300 learners with special needs, and 4 education officers. Saturated sampling technique was used to select 23 head-teachers, 70 teachers, 100 learners with special needs, and 4 education officers. Instruments for data collection were questionnaires, interview schedules and observation schedules. Quantitative data were analyzed using frequency counts, percentages, and mean. The findings of the study indicated that the availability and use of teaching and learning materials were inadequate (mean= 2.18). The study concluded that the low retention of learners with special needs as a result of the availability and use of teaching and learning materials to a small extent. The study recommended that the country and national government should ensure that there is adequate provision of teaching and learning resources to enhance learning for learners with special needs. The budget for materials should be enhanced. The study also recommends to non-governmental organizations to assist regular primary schools to access teaching and learning materials that can be used by learners with special needs.
PROBLEM DOKTRIN RASISME ETNIS CHINA SEBAGAI WNI (STATUS KEWARGANEGARAAN ETNIS CHINA)
Authors: Sunaryo Sidik , Purnamawati Shinta Ayu 
Published: June 2020

Keanekaragaman harus menjadi kekayaan dan bukan hanya sekedar beda yang satu. Tulisan ini mencoba menjelaskan problem doktrin hukum formal Negara (Konstitusi) yang mengatur tentang hubungan antara Ras (Keturunan atau Etnik) yang ada di Indonesia. Hukum tentang pengaturan Ras (Keturunan atau Etnik) di Indonesia, tidak bisa dilihat dari perspektif baik dan buruk saja, tetapi hukum pengaturan Ras (Keturunan atau Etnik) di Indonesia harus dilihat dalam perspektif benar dan salah. Antara ketentuan satu dengan yang lainnya masih saling bertentangan yang menjadi penyebab problem konstitusional ketidakteraturan hukum yang mengatur jaminan hak dan kewajiban bagi WNI ras dan etnis China secara sejajar dengan WNI asli. Pembedaan WNI asli dan tidak asli menjadi bukti problem ketidakteraturan hukum yang menjustifikasi Rasisme di Indonesia. Hal ini mengakibatkan perbedaan perlakuan dari penyelenggara Negara terhadap WNI tidak asli dari ras dan etnis China dalam bidang sosial, budaya, agama, kependudukan dan keimigrasian.
A Semianalytical Method for Two-Phase Flowback Rate-Transient Analysis in Shale Gas Reservoirs
Authors: Zhang Fengyuan , Emami-Meybodi Hamid 
Published: June 2020

Summary
We propose a new semianalytical method for analyzing flowback water and gas production data to estimate hydraulic fracture (HF) properties and to quantify HF dynamics. The method includes a semianalytical flowback model, a set of two-phase diagnostic plots, and a workflow to evaluate initial fracture volume and permeability, as well as fracture compressibility and permeability modulus. The flowback model incorporates two-phase water and gas flow in both HF and matrix domains and considers variations of fluid and rock properties with pressure. The HF domain is modeled by boundary-dominated flow, whereas an infinite-acting linear flow is assumed for the matrix domain. The flowback model is developed by assigning the variable average pressure in the fracture as the inner boundary condition for matrix according to Duhamel's principle. The average pressure in the fracture and distance of investigation (DOI) in the matrix are calculated from a modified material-balance equation by updating the matrix DOI as well as phase saturation and relative permeability in both the fracture and matrix domains. A modified DOI equation is used for two-phase flow in the matrix, which considers the pressure-dependent fluid and rock properties in pseudotime. The diagnostic plots shed light on the identification of flow regimes during the coupled two-phase flow in both fracture and matrix. The proposed workflow quantifies the HF dynamics through the loss of both fracture volume and fracture permeability by reconciling flowback and long-term production data. The accuracy of the new method is tested against numerical simulations conducted by a commercial numerical simulator. The validation results confirm that the proposed method accurately predicts initial fracture volume, permeability, and permeability modulus. Further, we use production data from a multifractured horizontal well (MFHW) drilled in Marcellus Shale to test the practicality of the proposed method. The results show a significant reduction in fracture volume and permeability during production attributable to the HF closure.
Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis
Authors: Lin Juli , Lin Jian-xian , Zheng Chao-hui , Li Ping , Xie Jian-wei , Wang Jia-bin , Lu Jun , Chen Qi-yue , Cao Long-Long , Lin Mi , Huang Chang-ming 
Published: June 2020

Abstract
Background: Many studies have found that use of aspirin can lengthen survival in patients with gastrointestinal cancer. The aim of this study was to assess the survival benefit of aspirin use compared with non-aspirin use for patients with esophageal, gastric or colorectal cancer.Methods: We searched online databases, including PubMed, the Cochrane Library, Embase and www.clinicaltrials.gov for studies that were conducted, before April 30th, 2020, to identify relevant studies. Overall survival and cancer-specific survival of esophageal, gastric and colorectal cancers among aspirin users were compared with those among non-aspirin users. Data extraction and quality evaluation were independently conducted by 2 investigators. A meta-analysis was performed to calculate the pooled risk ratios (RRs) for overall survival and cancer-specific survival by using either a fixed-effects model or a random-effects model.Results: A total of 18 studies were included in this meta-analysis, with more than 74,936 patients. There were no significant differences between postdiagnosis aspirin use and overall survival for esophageal and gastric cancers. For colorectal cancer, a benefit that was associated with postdiagnosis aspirin use was observed for overall survival and cancer-specific survival [HR= 0.83, 95%CI(0.75, 0.9.);HR= 0.78, 95%CI(0.66, 0.92), respectively. However, a prediagnosis of aspirin use did not provide a benefit for overall or cancer-specific survival in colorectal cancer. HR values for overall and cancer-specific survival benefits for colorectal cancer associated with both prediagnosis and postdiagnosis aspirin were as follows: HR=0.75，95%CI(0.61, 0.92) and HR=0.78, 95%CI(0.73, 0.85), respectively. In addition, the survival benefit of postdiagnosis aspirin use appeared to be confined to patients with mutated PIK3CA tumors [HR= 0.78, 95%CI(0.50, 0.99)] and was positive for PTGS2 (COX-2) expression [HR= 0.75, 95%CI(0.43, 1.30)].Conclusions: These findings provide further indications that postdiagnosis aspirin use improves overall survival and cancer-specific survival in colorectal cancer, especially for patients who are positive for PTGS2 (COX-2) expression and PIK3CA-mutated tumors. However, aspirin therapy does not improve overall survival in esophageal and gastric cancers, although the meta-analysis was mainly limited to retrospective studies.
Importance of congruence between communicating and executing implementation programmes: A qualitative study of focus-group interviews.​
Authors: Lindholm Lars H. , Laitila Minna , Lassila Antero , Kampman Olli 
Published: June 2020

Abstract
Background
The Ostrobothnia Depression Programme (ODP) in Finland was intended to implement two evidence-based brief psychotherapy interventions, namely motivational interview and behavioural activation, in several regional psychiatric teams. A simultaneous effectiveness study was conducted. Considerable tension was encountered between these two arms, causing resistance to change. We conducted a qualitative case study to better understand this tension and to ascertain how managerial and executive practices may ensure the successful running of a hybrid design programme.

Methods
We conducted focus group interviews to evaluate the phases of preparation and practical execution of the ODP from the perspectives of management and the programme executives. To gather the data, we applied the revised Socratic approach for health technology assessment and the rapid assessment process model. We analysed the data deductively according to Normalization Process Theory.

Results
We identified two main critical issues: 1) Incongruence occurred between what the project group had explicitly communicated about being the spearhead of the ODP and what they then actually enacted. 2) The ODP programme plan ignored the team leaders' crucial role in influencing the implementation climate and mobilizing organizational strategies. The ODP had a simplistic top-down design with minimal and delayed collaboration with its target groups in the preparation phase. These caused tension between the implementation efforts and the effectiveness study as well as resistance to change among the staff.

Conclusion
Early, open collaboration with all prospective stakeholders towards a shared understanding about the programme is the first action the programme administrators should take. Agreement on goals and the means to achieve them would lower tension between the two arms of a hybrid design programme, thereby reducing resistance to change. Congruence between the goals communicated and the actual managerial and executive actions is of paramount importance in getting the programme recipients on board.
Comparative transcriptome analysis between inbred and hybrids reveals molecular insights into yield heterosis of upland cotton
Authors: Shahzad Kashif , Zhang Xuexian , Guo Liping , Qi Tingxiang , Bao Lisheng , Zhang Meng , Zhang Bingbing , Wang Hailin , Tang Huini , Qiao Xiuqin , Feng Juanjuan , Wu Jianyong , Xing Chaozhu 
Published: June 2020

Abstract
Background

Utilization of heterosis has greatly improved the productivity of many crops worldwide. Understanding the potential molecular mechanism about how hybridization produces superior yield in upland cotton is critical for efficient breeding programs.

Results

In this study, high, medium, and low hybrids varying in the level of yield heterosis were screened based on field experimentation of different years and locations. Phenotypically, high hybrid produced a mean of 14% more seed cotton yield than its better parent. Whole-genome RNA sequencing of these hybrids and their four inbred parents was performed using different tissues of the squaring stage. Comparative transcriptomic differences in each hybrid parent triad revealed a higher percentage of differentially expressed genes (DEGs) in each tissue. Expression level dominance analysis identified majority of hybrids DEGs were biased towards parent like expressions. An array of DEGs involved in ATP and protein binding, membrane, cell wall, mitochondrion, and protein phosphorylation had more functional annotations in hybrids. Sugar metabolic and plant hormone signal transduction pathways were most enriched in each hybrid. Further, these two pathways had most mapped DEGs on known seed cotton yield QTLs. Integration of transcriptome, QTLs, and gene co-expression network analysis discovered genes Gh_A03G1024, Gh_D08G1440, Gh_A08G2210, Gh_A12G2183, Gh_D07G1312, Gh_D08G1467, Gh_A03G0889, Gh_A08G2199, and Gh_D05G0202 displayed a complex regulatory network of many interconnected genes. qRT-PCR of these DEGs was performed to ensure the accuracy of RNA-Seq data.

Conclusions

Through genome-wide comparative transcriptome analysis, the current study identified nine key genes and pathways associated with biological process of yield heterosis in upland cotton. Our results and data resources provide novel insights and will be useful for dissecting the molecular mechanism of yield heterosis in cotton
X-linked muscular dystrophy in a Labrador Retriever strain: phenotypic and molecular characterization.
Authors: Barthelemy Inès , Calmels Nadège , Weiss Robert B. , Tiret Laurent , Vulin Adeline , Wein Nicolas , Peccate Cécile , Drougard Carole , Beroud Christophe , Deburgrave Nathalie , Thibaud Jean-Laurent , Escriou Catherine , Punzon Isabel , Garcia Luis , Kaplan Jean-Claude , Flanigan Kevin M. , Leturcq France , Blot Stéphane 
Published: June 2020

Abstract
BackgroundCanine models of Duchenne muscular dystrophy (DMD) are a valuable tool to evaluate potential therapies because they faithfully reproduce the human disease. Several cases of dystrophinopathies have been described in canines, but the GRMD (Golden Retriever Muscular Dystrophy) model remains the most used in preclinical studies. Here we report a new spontaneous dystrophinopathy in a Labrador retriever strain, named LRMD (Labrador Retriever Muscular Dystrophy).MethodsA colony of LRMD dogs was established from spontaneous cases. Fourteen LRMD dogs were followed-up and compared to the GRMD standard using several functional tests. The disease causing mutation was studied by several molecular techniques and identified using RNA-sequencing.ResultsThe main clinical features of the GRMD disease were found in LRMD dogs; the functional tests provided data roughly overlapping with those measured in GRMD dogs, with similar inter-individual heterogeneity. The LRMD causal mutation was shown to be a 2.2‑Mb inversion disrupting the DMD gene within intron 20 and involving the TMEM47 gene. In skeletal muscle, the Dp71 isoform was ectopically expressed, probably as a consequence of the mutation. We found no evidence of polymorphism in either of the two described modifier genes LTBP4 and Jagged1. No differences were found in Pitpna mRNA expression levels that would explain the inter-individual variability.ConclusionsThis study provides a full comparative description of a new spontaneous canine model of dystrophinopathy, found to be phenotypically equivalent to the GRMD model. We report a novel large DNA mutation within the DMD gene and provide evidence that LRMD is a relevant model to pinpoint additional DMD modifier genes.
A comprehensive multivariate model of biopsychosocial factors associated with opioid misuse and use disorder in a 2017-2018 United States national survey
Authors: Ishino Francisco Alejandro Montiel , Gilreath Tamika , Salmeron Bonita , Williams Faustine 
Published: June 2020

Abstract
Background: Few studies have comprehensively and contextually examined the relationship of variables associated with opioid use. Our purpose was to fill a critical gap in comprehensive risk models of opioid misuse and use disorder in the United States by identifying the most salient predictors.Methods: A multivariate logistic regression was used on the 2017 and 2018 National Survey on Drug Use and Health, which included all 50 states and the District of Columbia of the United States. The sample included all noninstitutionalized civilian adults aged 18 and older (N=85,580; weighted N=248,008,986). The outcome of opioid misuse and/or use disorder was based on reported prescription pain reliever and/or heroin use dependence, abuse, or misuse. Biopsychosocial predictors of opioid misuse and use disorder in addition to sociodemographic characteristics and other substance dependence or abuse were examined in our comprehensive model. Biopsychosocial characteristics included socioecological and health indicators. Criminality was the socioecological indicator. Health indicators included self-reported health, private health insurance, psychological distress, and suicidality. Sociodemographic variables included age, sex/gender, race/ethnicity, sexual identity, education, residence, income, and employment status. Substance dependence or abuse included both licit and illicit substances (i.e., nicotine, alcohol, marijuana, cocaine, inhalants, methamphetamine, tranquilizers, stimulants, sedatives). Results. The comprehensive model found that criminality (adjusted odds ratio [AOR]=2.58, 95% confidence interval [CI]=1.98-3.37, p<0.001), self-reported health (i.e., excellent compared to fair/poor [AOR=3.71, 95%CI=2.19-6.29, p<0.001], good [AOR=3.43, 95%CI=2.20-5.34, p<0.001], and very good [AOR=2.75, 95%CI=1.90-3.98, p<0.001]), no private health insurance (AOR=2.12, 95%CI=1.55-2.89, p<0.001), serious psychological distress (AOR=2.12, 95%CI=1.55-2.89, p<0.001), suicidality (AOR=1.58, 95%CI=1.17-2.14, p=0.004), and other substance dependence or abuse were significant predictors of opioid misuse and/or use disorder. Substances associated were nicotine (AOR=3.01, 95%CI=2.30-3.93, p<0.001), alcohol (AOR=1.40, 95%CI=1.02-1.92, p=0.038), marijuana (AOR=2.24, 95%CI=1.40-3.58, p=0.001), cocaine (AOR=3.92, 95%CI=2.14-7.17, p<0.001), methamphetamine (AOR=3.32, 95%CI=1.96-5.64, p<0.001), tranquilizers (AOR=16.72, 95%CI=9.75-28.65, p<0.001), and stimulants (AOR=2.45, 95%CI=1.03-5.87, p=0.044). Conclusions. Biopsychosocial characteristics such as socioecological and health indicators, as well as other substance dependence or abuse were stronger predictors of opioid misuse and use disorder than sociodemographic characteristics.