bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of the heat treatment of additively manufactured Ni-base superalloy IN718
Authors: Diepold Benedikt , Vorlaufer Nora , Neumeier Steffen , Gartner Thomas , Göken Mathias 
Published: May 2020

AbstractAdditive manufacturing (AM) of Ni-base superalloy components can lead to a significant reduction of weight in aerospace applications. AM of IN718 by selective laser melting results in a very fine dendritic microstructure with a high dislocation density due to the fast solidification process. The complex phase composition of this alloy, with three different types of precipitates and high residual stresses, necessitates adjustment of the conventional heat treatment for AM parts. To find an optimized heat treatment, the microstructures and mechanical properties of differently solution heat-treated samples were investigated by transmission and scanning electron microscopy, including electron backs-catter diffraction, and compression tests. After a solution heat treatment (SHT), the Nb-rich Laves phase dissolves and the dislocation density is reduced, which eliminates the dendritic substructure. SHT at 930 or 954°C leads to the precipitation of the δ-phase, which reduces the volume fraction of the strengthening γ′- and γ″-phases formed during the subsequent two stage aging treatment. With a higher SHT temperature of 1000°C, where no δ-phase is precipitated, higher γ′ and γ″ volume fractions are achieved, which results in the optimum strength of all of the solution heat treated conditions.
Nonlinear regression analysis of the sorption of crystal violet and methylene blue from aqueous solutions onto an agro-waste derived activated carbon
Authors: Jasper Enebi Estella , Ajibola Victor Olatunji , Onwuka Jude Chinedu 
Published: May 2020

AbstractSorption of synthetic dyes on low-cost solid sorbents is a simple technique for their removal from wastewater. Recent initiatives in the sorption process have sought the use of activated carbon derived from agricultural wastes as it provides an attractive and cheaper alternative to commercial activated carbon, which is usually expensive. This research investigates the sorption kinetics and equilibrium of two synthetic cationic dyes, crystal violet and methylene blue from aqueous media using activated carbon prepared from an agro-waste, Millettia thonningii seed pods. Sorption experiments were carried out using the batch process. The kinetic data were analyzed using the pseudo-first-order, pseudo-second-order, and intraparticle diffusion models while the equilibrium data were analyzed using the Langmuir, Freundlich, and Redlich–Peterson isotherm models. Nonlinear regression method was used to fit the data to the isotherm models in order to determine model parameters and the best-fit isotherms. Thus, three error functions; coefficient of determination, Chi-square statistic test, and the sum of error squares were applied to evaluate the sorption data. The pseudo-second-order model best described the sorption kinetics of both dyes while the Redlich–Peterson model described the equilibrium data the most, followed closely by the Freundlich isotherm model indicating a heterogeneous sorbent surface. The experimental results indicate that the agro-waste derived activated carbon is a viable adsorbent for the remediation of dye-contaminated water.
Role of ley pastures in tomorrow’s cropping systems. A review
Authors: Martin Guillaume , Durand Jean-Louis , Duru Michel , Gastal François , Julier Bernadette , Litrico Isabelle , Louarn Gaëtan , Médiène Safia , Moreau Delphine , Valentin-Morison Muriel , Novak Sandra , Parnaudeau Virginie , Paschalidou Foteini , Vertès Françoise , Voisin Anne-Sophie , Cellier Pierre , Jeuffroy Marie-Hélène 
Published: May 2020

AbstractDiversification of cropping systems has been proposed as a major mechanism to move towards sustainable cropping systems. To date, a diversification option that has received little attention is introduction of ley pastures into cropping systems, but the use of ley pastures is challenged by most future-oriented scenarios aiming to feed the world sustainably. In these scenarios, ruminant livestock feed only on permanent pastures, while cropping systems focus completely on production of crop-based human food. Diversification of cropping systems with ley pastures is thus compromised by knowledge gaps and future-oriented policy options. Here, we review ecosystem services provided by introducing ley pastures into cropping systems to increase sustainability of agriculture, discuss types of ley pastures and their management liable to promote these services, and raise future challenges related to introducing ley pastures into cropping systems. We conclude that (1) ley pastures provide a large set of input (soil conservation, nutrient provision and recycling, soil water retention, biological control of pests) and output (water purification, climate regulation, habitat provision for biodiversity conservation, forage production) ecosystem services of primary importance to cropping systems and society, respectively, as long as their spatial and temporal insertion within cropping systems is well-managed; otherwise, disservices may be produced. (2) To benefit from ecosystem services provided by ley pastures in cropping systems while limiting their disservices, it appears necessary to define a safe operating space for ley pastures in cropping systems. Moving towards this space requires changing plant breeding programs towards multiservice ley pastures, producing knowledge about emerging ways of introducing ley pastures into cropping systems (e.g., living mulch, green manure) and better quantifying the bundles of ecosystem services provided by ley pastures in cropping systems.
Modeling the biogeochemistry of sulfur in beech (Fagus sylvatica L.) stands of the Vienna Woods
Authors: Dolschak Klaus , Berger Torsten W. 
Published: May 2020

AbstractIn this article, we describe the setup and the application of a novel Sulfur Dynamics Model (SDM), with the aim to identify and quantify processes, which are crucial for the understanding of the biogeochemical sulfur (S) cycle of forest ecosystems. The simulator takes into account abiotic processes as well as biotic interactions between atmosphere, plant and soil. We applied the model to two Austrian beech stands where deposition of S and soil solution chemistry were monitored intensively over a two-year period. Under consideration of high historic loads and the more recent recession of atmospheric S deposition, we found a suitable model configuration where it was possible to assign both intra-annual fluctuations of the SO4-S in soil solution and long-time trends in the stream discharge to specific S transformation processes. We identified the interplay of microbial immobilization (the microbial conversion of solute sulfate to organic soil S) and mineralization as key driver of short-term fluctuations in the soil solution. In the long term, the delayed release of historically accumulated S is driven mainly by the slow mineralization of S rich plant biomass, recalcitrant to decomposition. Adsorption and desorption processes seem to play only a negligible role on our investigated stands. We conclude that our proposed model which is based on the current understanding of S biogeochemistry is sufficient to describe S dynamics on the investigated forest stands. The code file (SAS) for all model functions will be provided by the authors after request.
The Christmas Market Attack in Berlin and Attitudes Toward Refugees: A Natural Experiment with Data from the European Social Survey
Authors: Nägel Christof , Lutter Mark 
Published: May 2020

AbstractUsing a quasi-experimental research design, this study examines changes in attitudes toward refugees after the terrorist attack on the Berlin Christmas market of December 19, 2016. In our analysis, we make use of random variation in the field period of the European Social Survey (ESS) to fashion a natural experimental design. The survey’s field period took place in Germany from August 23, 2016, to March 26, 2017. Hence, the Christmas market attack took place approximately halfway through the ESS’s field phase, thus making it possible to study the causal effect on changing attitudes toward minorities before and after the attack. We argue that the terrorist attack creates a spillover effect and negatively shapes public opinion of uninvolved ethnic minorities. Our data analysis suggests that immediately after the event, only people with a right-wing political attitude appear to be affected by the proposed spillover effect. However, we find that the worsening of attitudes toward refugees can also be observed in the general population as time progresses. We do not find variation according to educational levels.
Revisiting a Remedy Against Chains of Unkindness
Authors: Schnedler Wendelin , Stephan Nina Lucia 
Published: May 2020

AbstractPrevious experiments observe a chain of unkindness: unkindly treated people treat an innocent third party unkindly. As a remedy, it has been proposed that the unkindly treated person engages in emotional regulation by writing a letter to the unkind person. Indeed, subjects who received little money were willing to leave more to a third person when they were writing a letter rather than waiting.Here, we examine whether emotional regulation is indeed behind this observation. In line with emotional regulation, we find that letter writing also leads to more giving if the person is treated unkindly by being assigned to a frustrating rather than a pleasant job. Being able to write, however, does not affect self-reported happiness differently from having to wait. Even more strikingly, subjects assigned to pleasant jobs also give more when writing rather than waiting. This is not consistent with emotional regulation.
Experimental manipulation of beliefs about the importance of thoughts and the effect on an aggressive impulse
Authors: Jiménez-Ros A. , Faísca L. , Martins T. , Janeiro L. , Martins A.T. 
Published: May 2020

AbstractBackground:Cognitive models of obsessive-compulsive disorder attribute a causal role to maladaptive beliefs.Aims:To test this hypothesis, we manipulated Overimportance of Thoughts (OT) beliefs and experimentally evaluated their effect on the response to an induced aggressive impulse.Method:Eighty-five participants completed a battery of self-report instruments assessing obsession symptoms, thought control, affectivity and obsessive beliefs, and were then randomly assigned to two conditions. In the experimental condition participants read a scientific abstract on the importance of thought control whilst those in the control condition read a neutral abstract. All participants identified a loved person and imagined feeling the impulse to stab this person, then completed again OT beliefs measures (Overimportance of Thought, Moral-Thought Action Fusion and Thought Action Fusion Likelihood).Results:The Moral component of the Thought Action Fusion was reduced by reading a brief text about the possibility and desirability of thought control. However, experimentally induced changes in beliefs did not yield differences in the intrusiveness of the aggressive impulse.Conclusions:Some beliefs can be modified through a single session in which information similar to what could be obtained in quotidian life is provided.
Structural and Functional Characterization of the Tongue and Digestive Tract ofPsammophis sibilans(Squamata, Lamprophiidae): Adaptive Strategies for Foraging and Feeding Behaviors
Authors: El-Mansi Ahmed A. , Al-Kahtani Mohamed A. , Abumandour Mohamed M. A. , Ahmed Ahmed E. 
Published: May 2020

AbstractWe describe the morphological adaptations of the tongue and gastrointestinal tract of the striped sand snakePsammophis sibilansand discuss their functional importance. Using standard histological, histochemical, and scanning electron microscopy techniques, we analyzed 11 adult snakes of both sexes. Our findings showed that the bifurcated non-papillate tongue exhibited chemoreceptive adaptions to squamate foraging behavior. The lingual apex tapered terminally with sensory spines, and the body of the tongue possesses a characteristic central odor–receptor chamber that might serve to trap and retain scent molecules. Furthermore, the intrinsic musculature showed interwoven and well-developed transverse, vertical and longitudinal muscle fibers that control contraction and retraction during probing and flicking. The esophagus displayed highly folded mucosa lined with columnar epithelium with goblet cells. In contrast, the stomach mucosa formed finger-like gastric rugae, encompassing tubular glands with dorsal gastric pits. The intestine is distinct from other vertebrates in lacking the crypts of Lieberkühn in the tunica mucosa and submucosa. The intestine mucosa is mostly arranged in interdigitating villi oriented perpendicular to the luminal surface. We extrapolated subtle variations for both acid and neutral mucopolysaccharides and glycoproteins localization as well as collagen fibers using histochemical analyses. The elaborate histo-morphological and functional adaptation of the tongue and digestive tract plays a pivotal role in foraging and feeding behavior.
Evaluation of Data‐Based Estimates of Anthropogenic Carbon in the Arctic Ocean
Authors: Terhaar J. , Tanhua T. , Stöven T. , Orr J. C. , Bopp L. 
Published: May 2020

AbstractThe Arctic Ocean is particularly vulnerable to ocean acidification, a process that is mainly driven by the uptake of anthropogenic carbon (Cant) from the atmosphere. Although Cant concentrations cannot be measured directly in the ocean, they have been estimated using data‐based methods such as the transient time distribution (TTD) approach, which characterizes the ventilation of water masses with inert transient tracers, such as CFC‐12. Here, we evaluate the TTD approach in the Arctic Ocean using an eddying ocean model as a test bed. When the TTD approach is applied to simulated CFC‐12 in that model, it underestimates the same model's directly simulated Cant concentrations by up to 12%, a bias that stems from its idealized assumption of gas equilibrium between atmosphere and surface water, both for CFC‐12 and anthropogenic CO2. Unlike the idealized assumption, the simulated partial pressure of CFC‐12 (pCFC‐12) in Arctic surface waters is undersaturated relative to that in the atmosphere in regions and times of deep‐water formation, while the simulated equivalent for Cant is supersaturated. After accounting for the TTD approach's negative bias, the total amount of Cant in the Arctic Ocean in 2005 increases by 8% to 3.3 ± 0.3 Pg C. By combining the adjusted TTD approach with scenarios of future atmospheric CO2, it is estimated that all Arctic waters, from surface to depth, would become corrosive to aragonite by the middle of the next century even if atmospheric CO2 could be stabilized at 540 ppm.
Constraining Millennial‐Scale Changes in Northern Component Water Ventilation in the Western Tropical South Atlantic
Authors: Campos Marília C. , Chiessi Cristiano M. , Venancio Igor M. , Pinho Tainã M.L. , Crivellari Stefano , Kuhnert Henning , Schmiedl Gerhard , Díaz Rut A. , Albuquerque Ana Luiza S. , Portilho‐Ramos Rodrigo C. , Bahr André , Mulitza Stefan 
Published: May 2020

AbstractNegative excursions in the stable carbon isotopic composition (δ13C) at Atlantic intermediate to mid‐depths are common features of millennial‐scale events named Heinrich Stadials. The mechanisms behind these excursions are not yet fully understood, but most hypotheses agree on the central role played by the weakening of the Atlantic meridional overturning circulation. Marine records registering millennial‐scale negative δ13C excursions in the Atlantic are mostly restricted to the Heinrich Stadials of the last deglacial, while the Heinrich Stadials of the last glacial are poorly studied. Here, we constrain changes in bottom water ventilation in the western tropical South Atlantic mid‐depth during Heinrich Stadials of the last glacial and deglacial by investigating marine core M125‐95‐3. The concurrent decreases in benthic foraminifera δ13C and increases in bulk sediment sulfur indicate an increased Northern Component Water (NCW) residence time in the western tropical South Atlantic mid‐depth during Heinrich Stadials. Furthermore, a coherent meridional pattern emerges from the comparison of our new data to previously published mid‐depth records from the western South Atlantic. While our record shows the largest negative δ13C excursions during almost all Heinrich Stadials, the western equatorialAtlantic showed medium and the subtropical South Atlantic showed the smallest negative excursions. This meridional pattern supports the notion that during Heinrich Stadials, a reduction in the NCW δ13C source signal together with the accumulation of respired carbon at NCW depths drove the negative δ13C excursions. We suggest that the negative δ13C excursions progressively increase along the NCW southwards pathway until the signal dissipates/dilutes by mixing with Southern Component Water.
RETRACTED ARTICLE: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Authors: Zhang Jianhao , Duan Hongjian , Feng Zhipeng , Han Xinwei , Gu Chaohui 
Published: May 2020

AbstractCancer cells adapt to nutrient-deprived tumor microenvironment during progression via regulating the level and function of metabolic enzymes. Acetyl-coenzyme A (AcCoA) is a key metabolic intermediate that is crucial for cancer cell metabolism, especially under metabolic stress. It is of special significance to decipher the role acetyl-CoA synthetase short chain family (ACSS) in cancer cells confronting metabolic stress. Here we analyzed the generation of lipogenic AcCoA in bladder cancer cells under metabolic stress and found that in bladder urothelial carcinoma (BLCA) cells, the proportion of lipogenic AcCoA generated from glucose were largely reduced under metabolic stress. Our results revealed that ACSS3 was responsible for lipogenic AcCoA synthesis in BLCA cells under metabolic stress. Interestingly, we found that ACSS3 was required for acetate utilization and histone acetylation. Moreover, our data illustrated that ACSS3 promoted BLCA cell growth. In addition, through analyzing clinical samples, we found that both mRNA and protein levels of ACSS3 were dramatically upregulated in BLCA samples in comparison with adjacent controls and BLCA patients with lower ACSS3 expression were entitled with longer overall survival. Our data revealed an oncogenic role of ACSS3 via regulating AcCoA generation in BLCA and provided a promising target in metabolic pathway for BLCA treatment.
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer
Authors: Zheng Yan , Wu Chao , Yang Jimeng , Zhao Yue , Jia Huliang , Xue Min , Xu Da , Yang Feng , Fu Deliang , Wang Chaoqun , Hu Beiyuan , Zhang Ze , Li Tianen , Yan Shican , Wang Xuan , Nelson Peter J. , Bruns Christiane , Qin Lunxiu , Dong Qiongzhu 
Published: May 2020

AbstractEnolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis, but its potential function in pancreatic ductal adenocarcinoma (PDAC) is unclear. In this study, we observed a significant overexpression of ENO2 in PDAC tissues, and its expression was correlated with metastasis and poor prognosis in PDAC patients. K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity, cell metabolism and PDAC progression. Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC. Re-expression of wild-type (WT) ENO2, but not the K394 acetylation mimetic mutant, could reverse the decreased tumor malignancy. We further characterized histone deacetylase 3 (HDAC3) and P300/CBP-associated factor (PCAF) as the potential deacetylase and acetyltransferase for ENO2, respectively. HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis. Importantly, insulin-like growth factor-1 (IGF-1) was found to decrease K394 acetylation and stimulate ENO2 activity in a dose- and time-dependent manner. The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424, which promoted K394 deacetylation and activation of ENO2. Linsitinib, an oral small-molecule inhibitor of IGF-1R, could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway. Furthermore, linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2. Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis. Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC.
Right-sided brain lesions predominate among patients with lesional mania: evidence from a systematic review and pooled lesion analysis
Authors: Barahona-Corrêa J. Bernardo , Cotovio Gonçalo , Costa Rui M. , Ribeiro Ricardo , Velosa Ana , Silva Vera Cruz e. , Sperber Christoph , Karnath Hans-Otto , Senova Suhan , Oliveira-Maia Albino J. 
Published: May 2020

AbstractDespite claims that lesional mania is associated with right-hemisphere lesions, supporting evidence is scarce, and association with specific brain areas has not been demonstrated. Here, we aimed to test whether focal brain lesions in lesional mania are more often right- than left-sided, and if lesions converge on areas relevant to mood regulation. We thus performed a systematic literature search (PROSPERO registration CRD42016053675) on PubMed and Web-Of-Science, using terms that reflect diagnoses and structures of interest, as well as lesional mechanisms. Two researchers reviewed the articles separately according to PRISMA Guidelines, selecting reports of adult-onset hypomania, mania or mixed state following a focal brain lesion, for pooled-analyses of individual patient data. Eligible lesion images were manually traced onto the corresponding MNI space slices, and lesion topography analyzed using standard brain atlases. Using this approach, data from 211 lesional mania patients was extracted from 114 reports. Among 201 cases with focal lesions, more patients had lesions involving exclusively the right (60.7%) than exclusively the left (11.4%) hemisphere. In further analyses of 56 eligible lesion images, while findings should be considered cautiously given the potential for selection bias of published lesion images, right-sided predominance of lesions was confirmed across multiple brain regions, including the temporal lobe, fusiform gyrus and thalamus. These, and several frontal lobe areas, were also identified as preferential lesion sites in comparisons with control lesions. Such pooled-analyses, based on the most comprehensive dataset of lesional mania available to date, confirm a preferential association with right-hemisphere lesions, while suggesting that several brain areas/circuits, relevant to mood regulation, are most frequently affected.