bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Pelatihan Petugas Pemeriksa Jalur Rel Kereta Api (PPJ) di BPTP Sofyan Hadi
Authors: Alivya Reyna Rizky , Suprayekti Suprayekti 
Published: March 2020

Penelitian ini bertujuan untuk mendeskripsikan implementasi pelatihan petugas pemeriksa jalur rel kereta api (PPJ) di Balai Pelatihan Teknik Perkeretaapian (BPTP) Sofyan Hadi sesuai dengan komponen pelaksanaan pelatihan Blanchard dan Thacker yang terdiri dari instruktur pelatihan, alat dan bahan pelatihan, fasilitas pelatihan, dan media pelatihan. Penelitian ini merupakan penelitian deskriptif. Pengumpulan data dilakukan dengan observasi, kuesioner, dan wawancara. Observasi dilakukan untuk mengamati proses pelaksanaan pelatihan, kuesioner disebarkan kepada peserta pelatihan PPJ sebagai responden yang terlibat aktif dalam pelatihan, serta wawancara dilakukan kepada penyelenggara pelatihan yaitu pihak BPTP Sofyan Hadi. Hasil dari penelitian menunjukan bahwa implementasi pelatihan PPJ di BPTP Sofyan Hadi dapat dikategorikan â€œbaikâ€ pada komponen instruktur pelatihan, alat dan bahan pelatihan dan fasilitas pelatihan, sedangkan pada komponen media pelatihan dikategorikan â€œsangat baikâ€. Implikasi hasil penelitian ini adalah dapat dijadikan bahan pertimbangan guna meningkatkan kualitas pelaksanaan pelatihan PPJ berikutnya di perusahaan.
Pengembangan Buku Panduan Kredit pemilikan Rumah Subsidi di PT. Tata Bangun Sarana
Authors: Mulyani Sharah , Suprayekti Suprayekti , Widyaningrum Retno 
Published: March 2020

Abstract
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Penelitian pengembangan ini bertujuan menghasilkan buku panduan kredit pemilikan rumah subsidi yang dapat digunakan secara mandiri oleh konsumen di PT Tata Bangun Sarana. Penggunaan buku panduan kredit pemilikan rumah subsidi ini diharapkan mampu membantu konsumen dalam melalui tahapan pengajuan kredit dari tahap booking fee, melengkapi formulir persyaratan, wawancara, observasi/survei sampai dengan proses akad kredit. Penelitian ini menggunakan model pengembangan dari Rowntree yang melalui tiga tahapan yaitu (1) Tahap Perencanaan (2) Tahap Penulisan (3) Tahapan Penulisan dan Penyuntingan. Produk dievaluasi dengan menggunakan evaluasi formatif. Evaluasi formatif yaitu melalui uji coba ahli materi dan ahli media. Hasil yang diperoleh dari uji coba ahli materi adalah 3,7 sedangkan hasil uji coba ahli media adalah 3,37. Evaluasi juga dilakukan kepada konsumen melalui beberapa tahapan yaitu uji coba one to one yang memperoleh hasil 3,56. Kemudian uji coba Small Group Evaluation memperoleh hasil 3,64. Hasil keseluruhan dari semua tahapan uji coba adalah pengembangan buku panduan kredit pemilikan rumah subsidi sudah sangat baik. Buku panduan ini dapat membantu konsumen.

Abstract

The purpose of this developmental research is to produce mortgage subsidy guide books that can be studied independently by consumers in PT. Tata Bangun Sarana. The use of mortgage subsidy guide books expected to assist in filing stage through credit, from the stage of the booking fee, complete the requirement forms, obervation/survey, until the process of the contract credit. The research uses development model from Rowntree through three stage: (1) Planing Stage (2) Stages of Writing (3) Stages of Writing and Editing. Product are evaluated using formative. Formative evaluation is through the trial of material experts and media experts. The results obtained from a material expert trial is 3,7 while the trial results a media expert is 3,37. Evaluation is also conducted for consumer through several stages of one-to-one trial results 3,56. Then small group evaluation trial result is 3,54. The overall results from all of the trials are the development of mortgage subsidy guide books is already very good.
Geographically weighted regression modelling of the spatial association between malaria cases and environmental factors in Cameroon.
Authors: Tewara Marlvin Anemey , Yunxia Liu , Lin Weiqiang , Barong Binang Helen , Mbah-Fongkimeh Prisca Ngetemalah , Zhaolei Zheng , Xinhui Liu , Miao Zhou , Liu Xiaojuan , Xue Fuzhong 
Published: March 2020

Abstract
Background: Studies have illustrated the association of malaria cases with environmental factors in Cameroon but limited in addressing how these factors vary in space for timely public health interventions. Thus, we want to find the spatial variability between malaria hotspot cases and environmental predictors using Geographically weighted regression (GWR) spatial modelling technique.Methods: The global Ordinary least squares (OLS) in the modelling spatial relationships tool in ArcGIS 10.3. was used to select candidate explanatory environmental variables for a properly specified GWR model. The local GWR model used the global OLS candidate variables to examine, predict and explore the spatial variability between environmental factors and malaria hotspot cases generated from Getis-Ord Gi* statistical analysis. Results: The OLS candidate environmental variable coefficients were statistically significant (adjusted R2 = 22.3% and p < 0.01) for a properly specified GWR model. The GWR model identified a strong spatial association between malaria cases and rainfall, vegetation index, population density, and drought episodes in most hotspot areas and a weak correlation with aridity and proximity to water with an overall model performance of 0.243 (adjusted R2= 24.3%).Conclusion: The generated GWR maps suggest that for policymakers to eliminate malaria in Cameroon, there should be the creation of malaria outreach programs and further investigations in areas where the environmental variables showed strong spatial associations with malaria hotspot cases.
Knowledge on Genetic and Genomic Diagnostics among Sri Lankan Medical Practitioners
Authors: Jayawardana Sinhalage Mahesh Asantha 
Published: March 2020

Abstract
Objectives : Up-to-date knowledge on changing genetic and genomic diagnostic approaches is essential for a contemporary medical practitioner. This study was carried out to describe Sri Lankan Medical Practitioners’ current knowledge and opinion on modern genetic and genomic diagnostics techniques.
Results : Data was collected to an electronic database using an online self-administered questionnaire. A total of 123 respondents completed the questionnaire. Majority had either some or adequate knowledge on applications of basic genetic diagnostic methods such as karyotyping and polymerase chain reaction. Similarly most had either some or adequate knowledge on the use of predictive genetic tests in cancer. However the level of knowledge on the applications of modern diagnostic techniques like Fluorescent in-Situ Hybridization and Next Generation Sequencing remained poor. Majority had inadequate knowledge on newer concepts such as direct-to-consumer genetic testing and personalized medicine. Most agreed upon the inadequacy of undergraduate genetic education and the need of a continuous medical education program to fill this knowledge gap. Both undergraduate and continuous medical education approaches should be modified to improve the knowledge on increasingly complicated technological and ethical aspects associated with modern genetic diagnostics.
Loss of HtrA2/Omi protease activity induces mitonuclear imbalance and sarcopenia via differential regulation of mitochondrial biogenesis
Authors: Zhou Haohan , Yuan Danni , Gao Weinan , Tian Jiayi , Sun Hongyu , Yu Shuang , Sun Liankun , Wang Jincheng 
Published: March 2020

Abstract
The authors have withdrawn this preprint from Research Square
Prevalence of Primary Headache Disorders among Information Technology Staff in China: The Negative Effects of Computer Use and Other Correlative Factors
Authors: Li Chunlin , Zhang Lei , Zhou Jin , Fan zhiliang , Wang Yan , Wang Xiaolin , Wang Weidong , yu shengyuan 
Published: March 2020

Abstract
Background

To date, there have been very few studies that have explored the relationship between headaches and computer use. The chief aim of this study is to investigate the prevalence of primary headache disorders among informational technology staff and identify the potential factors contributing to it.

Methods

This is a cross-sectional study based on annual health checks of employees from the information technology industry. We identified 2216 information technology staff members from Beijing by stratified random sampling who met the inclusion criteria. All participants were initially required to have a physical examination, after which they complete a general situation questionnaire that included a headache screening question. Those who had suffered from headache within the previous year also completed the questionnaire developed by Lifting the Burden. The International Classification of Headache Disorders 3(ICHD-3) criteria was used for the diagnosis of headache.

Results

A total of 2012 valid questionnaires (males, 1544; females, 468) were obtained from 2216 participants for a response rate of 90.8%. A total of 619 participants were diagnosed with primary headache, the one-year prevalence of which was 30.8%. Regarding the classification of the primary headache, 152 participants suffered from migraine, with a one-year prevalence of 7.6%; 440 and 27 suffered from tension-type headache and unclassified headaches, with one-year prevalences of 21.9% and 1.3%, respectively. Multivariate regression analysis showed that female gender was a risk factor for migraine and tension-type headache (OR 3.21 and 1.88, respectively). Age was also related to migraine and tension-type headache. The 41-50 age group had 2.02 times the probability of migraine, and the 31-40 age group had 1.89 times the probability of tension-type headaches compared to the 18-30 age group. Obesity and excessive computer use (more than 12 hours per day) were also factors contributing to tension-type headache (OR: 2.61 and 1.63, respectively).

Conclusions

The one-year prevalence of primary headache in this population was 30.8%. The prevalence of tension-type headache in this population was higher than that in the general Chinese population. The occurrence of primary headache is correlated with many factors, among which excessive computer use significantly contributed to the risk of tension-type headache.
Detection of copy number variants in African goats using whole genome sequence data
Authors: Nandolo Wilson , Mészáros Gábor , Wurzinger Maria , Banda Liveness J. , Gondwe Timothy N. , Mulindwa Henry A. , Nakimbugwe Helen N. , Clark Emily L. , Woodward-Greene M. Jennifer , Liu Mei , Liu George E. , Tassell Curtis P. Van , Rosen Benjamin D. , Sölkner Johann 
Published: March 2020

Abstract
BackgroundCopy number variations (CNV) are a significant source of variation in the genome, as such they are essential to the genetic characterization of animal breeds. The aim of this study was to develop a fine-scaled copy number variation map for African goats. We used sequence data from multiple breeds and from multiple African countries. ResultsA total of 253,553 CNV (244,876 deletions and 8,677 duplications) were identified, corresponding to an overall average of 1,393 CNV per animal. The mean CNV length was 3.3 kb, with a median of 1.3 kb. There was substantial differentiation between the populations for some CNV, suggestive of the effect of population-specific selective pressures. A total of 6,231 global CNV regions (CNVR) were found across all animals, representing 59.2 Mb (2.4%) of the goat genome. About 1.6% of the CNVR were present in all 34 breeds and 28.7% were present in all 5 geographical areas across Africa, where animals had been sampled. The CNVR had genes that were highly enriched in important biological functions, molecular functions, and cellular components including retrograde endocannabinoid signaling, glutamatergic synapse and circadian entrainment. ConclusionsThis study presents the first fine CNV map of African goat based on WGS data and adds to the growing body of knowledge on the genetic characterization of goats.
Oral metoclopramide boosts lactogenesis II in mothers with preterm infants: a randomized placebo-controlled trial.
Authors: Fok Doris , Chan Yiong Huak , Ho Jiahui , RAuff Mary HJ , Chan Yah Shih , Chong Yap Seng , Mattar Citra NZ 
Published: March 2020

Abstract
Background: Preterm mothers at risk of delayed lactogenesis II may benefit from early pharmcological intervention to initiate breastfeeding onset. Research aim. To evaluate the effect of oral metoclopramide on lactogenesis II in mothers of preterm infants commencing within twelve hours of delivery. Methods: From April 2006 to May 2009,105 women were randomized to metoclopramide (term births, n=36;reterm n=20) or placebo (term,n=33;preterm,n=16). Mothers received 30 mg of oral metoclopramide daily for the first postnatal week in a randomized double-blinded placebo-controlled study. Primary outcome was augmentation of Lactogenesis II onset by postnatal day 3. Secondary outcomes were daily expression of breastmilk and maternal perception of lactogenesis II, breastfeeding practice and infant weight change over 6 months. Results: Metoclopramide achieved 25% augmentation in lactogenesis II onset (p=0.09) with greater expressed human milk volumes in mothers of preterm infants. Daily expressed human milk volumes was higher among preterm mothers on metoclopramide compared to term placebo mothers who served as controls, significant on day 2 (19.9 vs 2.4ml, p=0.04) and day 3 (32.6 vs 8.8ml,p=0.04),and total expressed human milk volumes had increased by 8.2 fold by the end of week one. Most mothers reported first initiation of lactogenesis II by day 6, with 95-100% of term mothers confirmed by day 5 (not significant). Conclusions: Short-term metoclopramide use starting within 12 postnatal hours boosted lactogenesisi II onset in preterm mothers, improving daily expressed human milk production and maternal perception of lactogenesis II onset.
Trends and Predictors of underweight among under-five children in Ethiopia, based on Ethiopian Demographic and Health Survey 2005 -2016. Multivariable Decomposition analysis
Authors: Birhan Tilahun Yemanu , Angaw Dessie Abebaw 
Published: March 2020

Abstract
Background Underweight is one of the paramount major worldwide health problems, and it touches a large number of population from infancy to old age. This study aimed to analyze the trends and predictors of change in underweight among under-five children in Ethiopia Method The data for this study were accessed from three Ethiopian Demographic and Health Surveys data set 2005, 2011 and 2016. The trend was examined separately for the periods 2005–2011, 2005-2016, and 2011-2016. Multivariate decomposition analysis of change in underweight was employed to answer the major research question of this study. The technique employed the output from the logistic regression model to parcel out the observed difference in underweight into components, and STATA 14 was utilized for data management and analysis. Result Among children in Ethiopia the prevalence of underweight declined from 38% in 2005 to 25% in 2016. The decomposition analysis indicated that almost half of the overall change in underweight was due to difference in characteristics. Change in the composition of parental education, wealth index, duration of breastfeeding, respondents’ occupation, was the major contributor for the decline of underweight, while the age of child and presence of diarrhea were contributors for the rise of underweight in Ethiopia. Conclusion underweight shows a remarkable decline over the last decades in Ethiopia. Change in composition of Birth size, duration of breastfeeding, household wealth quantile (richer) and husband/partner primary education are attributable to the decline of underweight.
Examining Trends in Sepsis and Sepsis Management by Non-Physician Clinicians in a Rural Ugandan Emergency Department Over a Decade.
Authors: Calo Sal , Rice Brian Travis , Kamugisha John Bosco , Kamara Nicholas , Chamberlain Stacey 
Published: March 2020

Abstract
Background: There is a paucity of data from Sub-Saharan Africa regarding sepsis outcomes and the impact of sepsis care on those outcomes, including the impact of care provided by non-physician clinicians (NPCs). Methods: Data were retrospectively analyzed from a rural Ugandan emergency department staffed by NPCs using a quality assurance database of adult and pediatric patient visits with and without sepsis from 2010 through 2018. Sepsis was defined as suspected infection with a qSOFA score ≥ 2. Mortality, disposition, and NPC adherence to intravenous fluid and anti-infective therapy were analyzed using chi-squared and multivariable linear regression. Results: Sepsis criteria were met in 4,847 (11.0%) cases. Sepsis cases compared to non-sepsis cases were significantly older, and had higher rates of comorbid malaria, HIV, tuberculosis, and pneumonia. They had higher admission rates (86.8% versus 66.3%), were more likely to still be admitted at three days (40.2% versus 26.2%), and had higher mortality at three days (7.8% versus 2.5%). The incidence of sepsis significantly declined over time from 16.3% in 2010 to 3.1% in 2018 while the proportion of sepsis cases with qSOFA score of ≥ 3 increased significantly over time. The decrease in incidence was largely due to a precipitous drop in malaria smear-positive sepsis. Utilizing a multivariable linear regression model, annual three-day sepsis mortality did not significantly change over time, though adherence to administration of both fluids and anti-infectives increased significantly from 12.3% in 2010 to 35.0% in 2018. Conclusions: Sepsis incidence, especially malaria smear-positive sepsis, decreased over time, while annual mortality did not change despite increased adherence to administration of anti-infectives and intravenous fluids in an NPC-staffed emergency department. Further studies are needed to investigate the contextualized use of anti-infectives and fluid resuscitation.
Two SNPs (rs1801282 and -1279G/A) of PPARγ are associated with Parkinson's disease in a northern Chinese population
Authors: li shanshan , Xue Li , Wang Huimin , Tian Qingwu , Xie Anmu 
Published: March 2020

Abstract
Background: This study aimed to assess the association between PPARγ gene polymorphism and susceptibility to Parkinson’s disease (PD) in a northern Chinese population.
Methods : We conducted a case-control study which including 391 outpatients with PD and 391 healthy matched individuals. All subject genotypes on PPARγ gene in rs3856806, rs1801282, -1279G/A were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.
Results : Our results showed participants with AG and AG+AA (dorminant model) genotypes of -1279G/A had a higher genetic risk of PD compared to those with GG ( p = 0.024, OR = 1.781, 95% CI = 1.073-2.956; p = 0.024,OR = 1.768, 95% CI = 1.078-2.898). A allele of the -1279G/A polymorphism was presumably correlated with increased risk of PD ( p = 0.037,OR = 1.639, 95% CI = 1.027-2.616) and male PD ( p =0.032, OR = 1.998, 95% CI = 1.051-3.798) as well as early-onset Parkinson’s disease (EOPD)( p =0.019, OR = 2.667, 95% CI = 1.263-5.629). Stratification analysis by age for rs1801282 indicated a significant genotype difference between EOPD and controls( p =0.005) as well as late-onset Parkinson’s disease(LOPD) and controls( p =0.008). G allele frequency of rs1801282 in EOPD subjects was significantly higher than it in controls( p = 0.006, OR =3.093, 95% CI = 1.446-6.615) and LOPD ( p = 0.009, OR =2.899, 95% CI = 1.344-6.253).
Conclusions : The study showed that in a northern Chinese population, the A allele of -1279G/A might be a risk factor for PD and the G alle of rs1801282 might increase the susceptibility of EOPD.
Heightened sensitivity to low-level visual information in autism during an emotional attentional blink task
Authors: Lacroix Adeline , Gomot Marie , Fombonne Margot , Perrier Mickaël J. R. , Peyrin Carole , Vermeulen Nicolas , Park Gewnhi , Dutheil Frédéric , Mermillod Martial 
Published: March 2020

Abstract
Background Impairments in facial emotion recognition have been a hallmark of autism, which may contribute to the difficulty in social engagement and interpersonal interaction. Impaired facial emotion recognition in autism could be partly due to the asymmetrical perceptual bias to High Spatial Frequencies (HSF) information observed during visual perception. While Low Spatial Frequencies (LSF) convey coarse information, which would be critical for a fast analysis and categorization of emotional faces, HSF convey local information, which may serve a critical role in visual consciousness. However, to our knowledge, the effect of HSF on visual consciousness in autism has not been specifically studied so far. Methods Thirty-three adult autistic participants and 35 typically developing (TD) control participants performed an emotional attentional blink paradigm. Participants had to identify and report two targets (happy faces, T1 and T2) embedded in a stream of distractors (angry faces). The distractors between T1 and T2 were unfiltered or filtered in HSF or LSF. We used ANOVA to compare the impact of spatial frequency information on visual consciousness in the two groups of participants. Results TD control participants showed significantly reduced T2 accuracy (i.e., accuracy for the second target given the correct report of the first target T1) after unfiltered and HSF distractors compared to LSF distractors. As predicted, reduced T2 accuracy was observed after HSF distractors in the autistic group as compared to the TD group. Although we did not hypothesized, we also found reduced T2 accuracy after LSF distractors in the autistic group. The accuracy between the two groups did not differ regarding unfiltered distractors. Limitations Our sample was adult, high functioning and mainly late diagnosed. Therefore, our findings may not generalize to the whole autistic population. Conclusion Results confirm that HSF plays a critical role in visual consciousness in both TD and autistic participants. More importantly, autistic participants demonstrated impaired target detections after filtered distractors, suggesting that they have enhanced sensitivity for low-level characteristics, such as high and low spatial frequencies filtering. These findings are discussed in the context of the Enhanced Perceptual Functioning theory and predictive coding frameworks.