bluuebunny/crossref_metadata_2025_split huggingface dataset:
APOL1 Nephropathy Risk Alleles and Risk of Sepsis in Blacks
Authors: Chaudhary Ninad S. , Moore Justin X. , Zakai Neil A. , Judd Suzanne E. , Naik Rakhi P. , Limou Sophie , Cushman Mary , Lange Leslie A. , Wang Henry E. , Winkler Cheryl A. , Irvin Marguerite R. , Kopp Jeffrey B. , Gutiérrez Orlando M. 
Published: November 2019

Background and objectives
apo L1 (APOL1) nephropathy risk alleles are associated with CKD in blacks. Although APOL1 has innate immune functions, little is known about the association of APOL1 genotypes with risk of infectious outcomes, such as sepsis. The objective of this study was to examine the associations of APOL1 nephropathy risk alleles with risk of sepsis in black adults.

Design, setting, participants, & measurements
We assessed the association of APOL1 risk alleles with incident sepsis in 10,366 black participants of the Reasons for Geographic and Racial Differences in Stroke study enrolled between 2003 and 2007 with follow-up through December 31, 2012. In Cox models adjusted for demographics, comorbid conditions, and principal components ancestry, we examined the association of APOL1 risk alleles with incident sepsis using recessive (comparing zero or one versus two risk alleles), dominant (zero versus one or two risk alleles), and additive genetic models. We also examined models stratified by diabetes and CKD status.

Results
A total of 1320 (13%) participants had two APOL1 risk alleles, 4719 (46%) had one risk allele, and 4327 (42%) participants had zero risk alleles. A total of 306 sepsis events occurred over a median 6.5 years (interquartile range, 4.5–8.1). There were no statistically significant associations of APOL1 genotype with sepsis risk under recessive genetic models. APOL1 genotypes were associated with sepsis risk under dominant (hazard ratio, 1.55; 95% confidence interval, 1.13 to 2.11) and additive (hazard ratio per variant allele copy, 1.25; 95% confidence interval, 1.02 to 1.53) genetic models adjusted for covariates and ancestry. These associations did not vary by diabetes or CKD status (P
interaction>0.10 for both).

Conclusions
In community-dwelling black adults, carriage of APOL1 nephropathy risk alleles are common and associated with higher risk of sepsis.
IbBM PELATIHAN PENERAPAN MODEL PEMBELAJARAN“INSTRUCTIONAL GAME”UNTUK PENINGKATAN PROFESIONALISME BAGI PENDIDIK PAUD SE KECAMATAN CIHIDEUNG KOTA TASIKMALAYA
Authors: Syaefuddin Syaefuddin , Yuliani Lulu , Oktiwanti Lesi 
Published: November 2019

Tujuan umum dalam rencana pelaksanaan pengabdian pada masyarakat ini adalah meningkatkan mutu pendidik PAUD di Kecamatan Cihideung Kota Tasikmalaya melalui pendampingan dalam kerangka meningkatkan kualitas pembelajaran melalui penerapan Model Pembelajaran“Instructional Game”Untuk Peningkatan Profesionalisme Bagi Pendidik Paud. Jenis luaran yang dihasilkan dari pelatihan melalui pendampingan ini adalah peningkatan kompetensi tutor dalam menerapkan model Pembelajaran“Instructional Game” pada pembelajaran PAUD. Berdasarkan penemuan dilapangan dan hasil wawancara dengan tutor PAUD di kecamatan Cihideung Kota Tasikmalaya pada umumnya mengharapkan seminar, dan pendampingan dalam penerapan model Pembelajaran“Instructional Game”Untuk Peningkatan Profesionalisme pendidik PAUD. Target yang ditetapkan dalam Pengabdian Masyarakat Iptek bagi Bina Masyarakat (IbBm) adalah Tutor diharapkan memiliki pengetahuan dan keterampilan dalam menerapkan model Pembelajaran “Instructional Game”. Tim pelaksana dalam kegiatan Pengabdian Pada Masyarakat ini berasal dari Perguruan Tinggi dari Stap pengajar Pendidikan Luar Sekolah UNSIL 3 orang sebagai dari bidang kepakaran Pendidikan Kemasyarakatan Non Formal dan Informal sebagai pendamping/ nara sumber.
MENINGKATKAN KEMAMPUAN BERPIKIR SIMBOLIK ANAK USIA DINI KELOMPOK A (USIA 4-5 TAHUN) DENGAN MEDIA PEMBELAJARAN LESUNG ANGKA
Authors: Bodedarsyah Ani , Yulianti Rita 
Published: November 2019

Cognitive development is an important aspect. One of them is the ability to think symbolically. To improve the ability of symbolic thinking of early childhood certainly cannot be separated from the role of educators. Indicators of cognitive development that must be achieved by children aged 4-5 years are: numbers 1-10, recognizing the concept of numbers, recognizing the symbol of numbers, and recognizing the symbol of letters. For this reason, it is appropriate for educators to work hard to improve the ability to think symbolically in early childhood by providing stimulation through appropriate learning media like children, one of which is the media learning of dimples. This research was conducted with a class action research method. From the two cycles that have been done show the results that there is an increase in the ability of symbolic thinking in early childhood group A using the media learning dimples.Perkembangan kognitif merupakan aspek yang tidak kalah penting. Salah satunya adalah kemampuan berpikir simbolik. Untuk meningkatkan kemampuan berpikir simbolik anak usia dini tentu tak lepas dari peranan pendidik. Indikator perkembangan kognitif yang harus dicapai anak usi 4-5 tahun adalah: membilang benda 1-10, mengenal konsep bilangan, mengenal lambang bilangan, dan mengenal lambang huruf. Untuk itu sudah selayaknya pendidik berusaha dengan keras untuk meningkatkan kemampuan berpikir simbolik anak usia dini dengan cara memberikan stimulasi melalui media pembelajaran yang tepat bagai anak, salah satunya adalah media pembelajaran lesung angka. Penelitian ini dilakukan dengan metode peneletian tindakan kelas. Dari dua siklus yang telah dilakukan menunjukkan hasil bahwa terdapat peningkatan kemmapuan berpikir simbolik pada anak usia dini kelompok A dengan menggunakan media pembelajaran lesung angka.
PERAN TOKOH PEMUDA DALAM MENINGKATKAN PARTISIPASI KARANG TARUNA DI DESA NANJUNG MARGAASIH
Authors: Nirmalasari Tiana , Widiastuti Novi 
Published: November 2019

Pemuda harus dilatih dan dibina agar memiliki jiwa sosial yang tinggi, memiliki nilai dan moral yang baik dan meningkatnya idealisme. Begitupun dalam tujuan penelitian ini adalah untuk menjabarkan (1) peran tokoh pemuda dalam meningkatkan partisipasi karang taruna di desa nanjung margaasih (2) Bentuk partisipasi anggota karang taruna dalamkegiatan-kegiatan karang taruna.Dalam penelitian ini Teori yang digunakan adalah teori kepemudaan, teori kepemimpinan dan teori partisipasi.Dalam penelitian ini, peneliti menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data melalui wawancara dan observasi. Penelitian ini dilakukan di RW 03 di Desa Nanjung Kecamatan Margaasih Kabupaten Bandung, yang menjadi responden penelitian adalah ketua, sekretaris, bendahara dan tiga anggota. Hasil dari penelitian ini yaitu (1) peran tokoh pemuda adalah membina, membimbing, dan memberikan inovasi (2) bentuk partisipasi ada partisipasi menggunakan harta, partisipasi menggunakan tenaga, partisipasi menggunakan uang, partisipasi menggunakan fikiran dan partisipasi menggunakan keterampilan.Kata Kunci: Karang Taruna, Partisipasi, Tokoh Pemuda.
PROGRAM PELATIHAN KETERAMPILAN TATA RIAS PENGANTIN DALAM UPAYA PENINGKATAN PENDAPATAN MASYARAKAT (Studi kasus Penelitian pada Peserta Didik di LKP HENNY’S Kota Cimahi)
Authors: Anjani Tiktik Regina Dewi , Darojatun Irfa 
Published: November 2019

Pendidikan Luar Sekolah adalah salah satu jalur pendidikan yang bertugas mencerdaskan kehidupan bangsa dengan tujuan memberikan kesempatan belajar seluas-luasnya bagi masyarakat. Jalur pendidikan luar sekolah merupakan pendidikan yang diselenggarakan di luar sekolah melalui kegiatan belajar mengajar yang tidak harus berkesinambungan. Pendidikan luar sekolah berhubungan dengan pendidikan kecakapan hidup, dalam hal ini penulis meneliti sebuah pelatihan tata rias pengantin yang diselenggarakan di LKP Henny’s dengan jumlah warga belajar berjumlah 20 orang dengan tutor/tenaga pengajar berjumlah 4 orang. Tujuan penelitian ini adalah untuk mengetahui sejauhmana peningkatan pendapatan masyarakat setelah mengikuti pelatihan tata rias pengantin. Teori yang digunakan dalam penelitian ini di antaranya adalah teori pelatihan, kecakapan hidup dan kewirausahaan .Penulisan ini menggunakan metode deskriptif kualitatif, yaitu melakukan Penulisan dengan tujuan ingin menggambarkan masalah dan melakukan analisis terhadap masalah. Masyarakat sebagai lingkungan memiliki pengaruh besar terhadap perkembangan pribadi seseorang. Masyarakat mempunyai peranan penting dalam upaya ikut serta menyelenggarakan pendidikan, karena membantu pengadaan sarana dan prasarana dan menyediakan lapangan kerja. Berdasarkan hasil Penulisan, pembahasan dan Dalam sistem pendidikan nasional pendidikan seumur hidup dikelola atas tanggunga jawab keluarga, sekolah dan masyarakat. Dimana masing-masing mempunyai tanggung jawab yang terpadu dalam rangka pencapaian tujuan nasional.
Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study
Authors: Pasquel Francisco J. , Tsegka Katerina , Wang Heqiong , Cardona Saumeth , Galindo Rodolfo J. , Fayfman Maya , Davis Georgia , Vellanki Priyathama , Migdal Alexandra , Gujral Unjali , Narayan K.M. Venkat , Umpierrez Guillermo E. 
Published: November 2019

OBJECTIVE
Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. We investigated hospital outcomes in patients with isolated or combined hyperglycemic crises.

RESEARCH DESIGN AND METHODS
We analyzed admissions data listing DKA or HHS at two academic hospitals. We determined 1) the frequency distributions of HHS, DKA, and combined DKA-HHS (DKA criteria plus elevated effective osmolality); 2) the relationship of markers of severity of illness and clinical comorbidities with 30-day all-cause mortality; and 3) the relationship of hospital complications associated with insulin therapy (hypoglycemia and hypokalemia) with mortality.

RESULTS
There were 1,211 patients who had a first admission with confirmed hyperglycemic crises criteria, 465 (38%) who had isolated DKA, 421 (35%) who had isolated HHS, and 325 (27%) who had combined features of DKA-HHS. After adjustment for age, sex, BMI, race, and Charlson Comorbidity Index score, subjects with combined DKA-HHS had higher in-hospital mortality compared with subjects with isolated hyperglycemic crises (adjusted odds ratio [aOR] 2.7; 95% CI 1.4, 4.9; P = 0.0019). In all groups, hypoglycemia (&lt;40 mg/dL) during treatment was associated with a 4.8-fold increase in mortality (aOR 4.8; 95% CI 1.4, 16.8). Hypokalemia ≤3.5 mEq/L was frequent (55%). Severe hypokalemia (≤2.5 mEq/L) was associated with increased inpatient mortality (aOR 4.9; 95% CI 1.3, 18.8; P = 0.02).

CONCLUSIONS
Combined DKA-HHS is associated with higher mortality compared with isolated DKA or HHS. Severe hypokalemia and severe hypoglycemia are associated with higher hospital mortality in patients with hyperglycemic crises.
Application potential and plasticity of human stem cells
Authors: Lorenz Mikołaj , Mozdziak Paul , Kempisty Bartosz , Dyszkiewicz-Konwińska Marta 
Published: November 2019

Abstract
Significant advances have been achieved in the study of stem cells over recent years. Stem cell isolation, their plasticity, differentiation and pre-clinical and clinical applications have undergone a significant study. The objective of this paper is to review the advances in stem cell isolation methods. There are many types of stem cells in the article. Isolation and subsequent differentiation of among others: Human adipose-derived stem cells, cancer stem cells, neural stem cells and mesenchymal stem cells. The subject of Endometrial mesenchymal stromal cells, whose isolation methods are relatively new, was also raised. Attention was paid to the development of preclinical studies using Dental Pulp Stem Cells in various diseases such as Parkinson’s disease or Alzheimer’s disease. Progress in research on the use of stem cells in the treatment of heart attacks, burns, bone injuries and the use of neural stem cells in animal models as an attempt to treat multiple sclerosis has been described.

Running title: Potential and plasticity of stem cells
Differences in Bioactive Protein and Vitamin Status of Milk Obtained from Polish Local Breeds of Cows
Authors: Brodziak Aneta , Król Jolanta , Barłowska Joanna , Litwińczuk Zygmunt , Teter Anna , Kędzierska-Matysek Monika 
Published: November 2019

Abstract
The aim of the study was to compare the content of selected bioactive whey proteins and lipophilic vitamins, which largely determine the bioactive status of milk, in milk obtained from local breeds of cows raised in Poland (Polish Red, White-Backed and Simmental) and Polish Holstein-Friesian cows. Basic chemical composition and content of selected bioactive compounds (β-lactoglobulin, α-lactalbumin, lactoferrin, bovine serum albumin, and vitamins: E, A, D3 and β-carotene) in 550 milk samples were analysed. The milk produced by local breeds proved to be a more valuable source of whey proteins and lipophilic vitamins than that of the Polish Holstein-Friesians. It was distinguished by its content of all bioactive compounds, including those with antioxidant properties, i.e. vitamins E, A and D3 and β-lactoglobulin, and antimicrobial properties, mainly lactoferrin. Therefore, the milk of cows of local breeds should be considered a valuable material for processing, especially at the level of the farm or small local processing plant, to produce products that are richer in health-promoting compounds. The promotion of milk from local breeds can therefore be an opportunity for the farms that raise them.
Root growth dynamics and productivity of quinoa (Chenopodium quinoa Willd.) in response to fertilization and soil tillage
Authors: Kakabouki Ioanna P. , Roussis Ioannis , Hela Dimitra , Papastylianou Panayiota , Folina Antigolena , Bilalis Dimitrios 
Published: November 2019

Abstract
Quinoa is a gluten-free pseudocereal crop recognized for its exceptional nutritional properties. A 3-year field experiment was conducted to evaluate the influence of soil tillage and fertilization on root growth and productivity of quinoa. The experiment was laid out in a split-plot design with two replicates, two main plots [conventional (CT) and minimum tillage (MT)] and four sub-plots [fertilization treatments: untreated, inorganic fertilization with 100 (N1) and 200 kg N ha−1 (N2), and sheep manure]. Mean weight diameter (MWD) of soil aggregates, total porosity, organic matter and soil total nitrogen increased with the long-term fertilization with sheep manure. The major part of the roots (approximately 70%) is concentrated in the 0-30 cm soil layer. Root length density increased with increased rate of applied nitrogen, and a higher value (1.172 cm cm−3) was found in N2 plots. Additionally, higher root mass density (1.114 mg cm−3) was observed under MT. Plant height and dry weight were clearly affected by fertilization, with higher values obtained in N2 plots. Moreover, it was observed that quinoa cultivated under CT and N2 treatment produced a higher seed yield (2595 kg ha−1). As a conclusion, increasing the levels of applied nitrogen up to 200 kg N ha−1 improves root growth and consequently the yields of quinoa.
Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity
Authors: Dasari Sreenivasulu , Ganjayi Muni Swamy , Meriga Balaji 
Published: November 2019

Abstract
Glutathione S-transferases (GSTs) are major defence enzymes of the antioxidant enzymatic system. Cytosolic GSTs are more involved in the detoxification than mitochondrial and microsomal GSTs. GSTs are localized in the cerebellum and hippocampus of the rat brain. Acrylamide (AC) is a well assessed neurotoxin of both animals and humans and it produces skeletal muscle weakness and ataxia. AC is extensively used in several industries such as cosmetic, paper, textile, in ore processing, as soil conditioners, flocculants for waste water treatment and it is present in daily consumed food products, like potato chips, French fries, bread, breakfast cereals and beverages like coffee; it is detected on tobacco smoking. GST acts as a biomarker in response to acrylamide. AC can interact with DNA and therefore generate mutations. In rats, low level expression of glutathione S-trasferase (GST) decreases both memory and life span. The major aim of this review is to provide better information on the antioxidant role of GST against AC induced neurotoxicity and genotoxicity.
Antidotal effects of thymoquinone against neurotoxic agents
Authors: Sanati Ali Rajabpour , Farkhondeh Tahereh , Samarghandian Saeed 
Published: November 2019

Abstract
Several plants which contain the active component thymoquinone (TQ) have been traditionally used in herbal medicine to treat various diseases. Several studies indicated the protective effects of TQ against neurotoxic agents. The present study was aimed to highlight the protective effects of TQ against neurotoxic agents. For this reason, the literature from 1998 to 2017 regarding the protective effects of TQ against neurotoxic agents and their involvement mechanisms has been studied. The present review suggests the protective effects of TQ against neurotoxic agents in experimental models. More clinical trial studies are however needed to confirm the antidotal effects of TQ in human intoxication.
Multiple giant cell formation – A consequence of type II pyrethroid intoxication
Authors: Bhushan Brijender , Saxena Prabhu Narain 
Published: November 2019

Abstract
Pesticides are the main remedy for pest eradication, but their use has been found to be harmful also to various non-target organisms. In this study, giant cell formation was observed in hepatocytes of experimental albino rats following two type II pyrethroid pesticdes, Cypermethrin and Beta-cyfluthrin. Histopathological examination was done for this purpose and the results revealed the formation of giant cells and polyploidy condition following intoxication of these experimental compounds with Beta-cyfluthrin, with an edge over, and Cypermethrin, probably due to structural differences.
Local benefits factored in utility scale wind energy for a remote location
Authors: Soliman Mohamed Hassan , Nesser Bassel I. , Pytel Krzysztof 
Published: November 2019

Abstract
The publication presents the results of analysis of possible local benefits factored in utility scale wind energy for a remote location. Electricity is one of the most vital problems on the Earth, thus utility scale wind and solar energy devices are boosting economic development. Energy demand is constantly increasing, despite efforts to ensure the energy efficiency of devices. People are looking for more energy and electricity to consume. Although wind energy is still being researched and improved, modern generation of wind energy is becoming more and more effective and desirable. This publication presents an effective solution to this issue. It deals with the generation of green environment friendly electricity from wind turbine. The genuine idea is to provide energy for remote location using onshore wind turbines. An analysis of the demand for energy at a remote location and electricity consumption was made to provide preliminary calculations of the wind farm. The number of required turbines is determined taking into account all related factors. A specific wind turbine has been selected and proposed to provide the necessary location with the necessary amount of energy. The analysis carried out showed that the produced energy is environment friendly since there is no carbon dioxide emission.
SPEECH ACTS PREFERENCE IN COMPUTER – MEDIATED INTERCULTURAL COMMUNICATION VIA FACEBOOK MESSENGER: A NETNOGRAPHIC STUDY
Authors: Nugraha Yehezkiel Adhi 
Published: November 2019

<p>People will not only use language for sharing message but also due to do an action. Through language, people will ask, promise, refuse, greet, invite, thank, and so on. The purpose of this research is to identify the speech acts preference used by Indonesian and Filipino non – native speakers of English via Facebook Messenger. Besides, to identify the similar or different of speech acts preference they used.</p><p> The source of data are utterances of conversation in Facebook Messenger. The researcher applies documentation and an observation (reading the book and internet as the references) in collecting the data. After collecting the data, the researcher analyzes the data by focusing the speech acts theory. In order to support the evidence of the result, the researcher needs to describe and compare the high context-cultures and low context-cultures by Hall (1976) and also cultural dimension of Indonesia and Philippines by Hofstede.</p>The result of the analysis shows that the most speech acts preference used by Indonesian and Filipino non - native speakers of English is direct speech act. Similar and different types of speech acts are found. The similar speech act preferences are found in declarations and representatives. The different speech acts preferences are found in expressives, directives, commissives, direct, and indirect speech acts. The result of this research also shows that the communication of Indonesian and Filipino are included into low contex-cultures. It is contrary with the theory of Hall and Hofstede which shows that Indonesia and Philippines factually should be high context-cultures.
AN ANALYSIS OF COHESION IN TEXTS MADE BY ELT 7TH STUDENTS OF IKIP PGRI MADIUN: A DISCOURSE ANALYSIS
Authors: Karistiantari Titis , Setyadi Dwi , Purnomosasi Lusia Kristiasih Dwi 
Published: November 2019

<p>The purpose of this research is to identify the cohesive devices and thematic progression which are constructed in texts made by ELT 7<sup>th</sup> Students of IKIP PGRI Madiun on Final Project of Psycholinguistic Class. This research is conducted by using Discourse Analysis and qualitative research approach. The type of this research is library research, using document as object. The technique of analysing data is Flow Model. This result of this research are: (1) The researcher finds that the cohesive devices which the most frequently used in all data is Reference with the total 122 reference, 5 substitution, 4 ellipsis, 86 conjunction, and 15 lexical cohesion. (2) The researcher finds that thematic progression in each data is different. Data one consists of 9 Linear TP and 8 Constant TP. Data two consists of 10 Linear TP, 7 Constant TP, 1 Split Theme, and 2 Split Rheme. Data Three consist of 4 Linear TP and 11 Constant TP. Data four consists of 18 Linear TP, 3 Constant TP, and 1 Split Rheme. And the last one is data five consists of 4 Linear TP, 2 Constant TP, and 2 Split Rheme. </p>