bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seed-Biopriming of Durum Wheat with Diazotrophic Plant Growth Promoting Bacteria (PGPB) Enhanced Tolerance to Fusarium Head Blight (FHB) and Salinity Stress
Authors: Brahim Adel Hadj , Jlidi Mouna , Daoud Lobna , Ben-Ali Manel , Akremi Asmahen , Hmani Houda , Feto Naser Aliye , Ben-Ali Mamdouh 
Published: December 2019

Abstract
Background There is growing interest in the use of bioinoculants based on plant growth promoting bacteria (PGPB) to promote plant growth under biotic and abiotic stresses. To our knowledge much work has not been, thus far, done on seedbiopriming of durum wheat for tolerance to biotic and abiotic stresses. In the present work, we report detailed account of the effectiveness a potent bacterial strain with proven plant growth-promoting ability and antimicrobial activity. The isolate was selected following screening of several bacterial strains isolated from halophytes that grow in a coastal saline soil in Tunisia for their role in enhancing durum wheat tolerance to both salinity stress and head blight disease. Results Accordingly, Bacillus strains MA9, MA14, MA17 and MA19 were found to have PGPB characteristics as they produced indole-3-acetic acid, siderophores and lytic enzymes, fixed free atmospheric nitrogen, and solubilized inorganic phosphate, in vitro. The in vivo study that involved in planta inoculation assays under control (25 mM NaCl) and stress (125 mM NaCl) conditions indicated that all PGPB strains significantly (P < 0.05) increased the total plant length, dry weight, root area, seed weight, nitrogen, protein and total mineral content. On the other hand, strain MA17 reduced Fusarium Head Blight (FHB) disease incidence in wheat explants by 64.5%, showing that the strain has antifungal activity as was also displayed by in vitro inhibition study. Conclusions Both in vitro and in vivo studies showed that MA9, MA14 MA9, MA14, MA17 and MA19 strains were able to play the PGPB role. Yet, biopriming with Bacillus strain MA17 offered the highest bioprotection against FHB, plant growth promotion, and salinity tolerance. Hence, the MA17 strain should further be evaluated under field condition and formulated for commercial production. Besides, the strain could further be evaluated for its potential role in bioprotection and growth promotion of other crop plants. We believe, the strain has potential to significantly contribute to wheat production in the arid and semi-arid region, especially the salt affected Middle Eastern Region, besides its potential role in improving wheat production under biotic and abiotic stresses in other parts of the world.
WITHDRAWN: Role of Short-wavelength Blue Light in the Formation of Cataract and Expression of Caspase-1, -11 and Gasdermin D in rat Lens Epithelium Cells: Insight into the Novel Pathogenesis of Cataract.
Authors: Wang Yamin , Zhang Min , Sun Ying , Wang Xiaohui , Song Zhaowei , Li Huazhang , Liu Kexin , Li Zhijian 
Published: December 2019

Abstract

Background Cataracts have been verified to be associated with a number of risk factors. The sun and artificial light sources, including light-emitting diode (LED) and fluorescent light tubes, are the primary sources of short-wavelength blue light. With the increasing popularity of blue-rich LED-backlit display devices, our eyes are now exposed to more short-wavelength blue light than they were in the past. The goal of this study was to evaluate the role of short-wavelength blue light in the formation of cataract. Additionally, the pathogenesis of cataracts after short-wavelength light exposure was investigated.Methods SD rats were randomly divided into 2 main groups: a control group (10 rats each for the 4-, 8-, and 12-week groups) and an experimental group (10 rats each for the 4-, 8-, and 12-week groups). The rats in the experimental group were exposed to a short-wavelength blue LED lamp for 12 hours per day. After exposure to the blue LED lamp, the rats were maintained in total darkness for 12 hours, after which a 12-hour light/dark cycle was resumed. The intensity of the lamp was 3000 lux. At the end of the short-wavelength blue LED lamp exposure (for 4, 8, and 12 weeks), the expression levels of caspase-1, caspase-11 and gasdermin D (GSDMD) in rat epithelium cells (LECs) were examined in rat epithelial cells (LECs) using qRT-PCR and Western blotting analyses. Results After 6 weeks, cataracts had developed in the experimental rats (4/20 eyes). The clarity of the lens then gradually worsened with the duration of exposure. Twelve weeks later, all of the rat eyes had developed cataracts. Then the expression levels of caspase-1, caspase-11 and GSDMD at 4, 8, and 12 weeks were significantly higher in samples from rats exposed to a short-wavelength blue LED lamp than samples from control rat (p˂0.05). Conclusion The data indicate that pyroptosis play a key role of in cataracts induced by short-wavelength blue light exposure, highlighting caspase-1, caspase-11 and GSDMD as possible therapeutic targets for cataract treatment. This study might provide new insight into the novel pathogenesis of cataracts.
Effects of preoperative, scheduled administration of antiemetics on reducing postoperative nausea and vomiting in patients undergoing total knee arthroplasty
Authors: Chang Moon Jong , Chang Chong Bum , Kang Seung-Baik , Park Hyung Jun , Hwang Keum Min , Hwang Il-ung 
Published: December 2019

Abstract
Background To date, there has been no established protocol regarding the timing of the scheduled administration of antiemetics in total knee arthroplasty (TKA). Previous prospective studies analyzing the scheduled use of antiemetics differed in the timing at which the drugs were administered. However, antiemetic drugs are not administered post-operatively until noxious stimuli caused by drugs used during anesthesia and operative procedures. The purpose of this study was 1) to determine whether preoperative scheduled administration of an antiemetic drug can reduce iatrogenic postoperative nausea and vomiting (PONV) in TKA compared to postoperative administration, and 2) to determine whether there was a difference in postoperative pain, patient satisfaction, and complications after TKA between pre- and postoperative administrations.Methods This retrospective study included patients who were assigned to either intravenous administration of the antiemetic drug (ramosetron) 1 hour before surgery (pre-injection group: 50 patients) or at the end of surgery (post-injection group: 51 patients). The incidence of PONV and the frequency of rescue medicine use were recorded until 48 hours postoperation. Postoperative pain level and satisfaction were also assessed using the visual analogue scale (VAS). Possible complications associated with serotonin receptor antagonists; for example, headaches, dizziness, and drowsiness were also assessed.Results The incidence of nausea events was lower in the pre-injection group than in the post-injection group. However, there was no difference between the two groups in terms of frequency of vomiting events and the use of rescue medicine for PONV. Also, postoperative pain, satisfaction scores, and incidence of complications were not different between the two groups.Conclusions The patients with preoperative scheduled administration of antiemetics showed lower incidence of nausea events than those with postoperative administration. However, it is difficult to conclude that the extent of the effect was clinically significant. Further research is needed to determine the optimal timing and method for more effective antiemetic treatment.
The impact of exercise of lower limbs on dynamic balance and valgus of the knees among young footballers
Authors: Wilczyński Bartosz , Zorena Katarzyna , Wąż Piotr 
Published: December 2019

Abstract
Background Participation of children and youth in sporting activities, among others in training and football competitions, is an optimistic manifestation of activation in the current trend of computerization. Unfortunately, this is also often associated with musculoskeletal injuries. An example is the association of dynamic valgus and disturbed dynamic balance with lower limb injuries. The main purpose of the studies is to determine the impact of three strengthening exercises on the parameters of dynamic knee valgus and balance of lower limbs. The secondary objectives are to investigate the dominant influence and the length of lower limb on the valgus values and to determine risk of injury to young football players. Methods 134 young footballers training at the Arka Gdynia SI club were invited to first stage of the research in order to examine anthropometric features and kinematics of the lower limb. Single Leg Squat Test was used, which was recorded. The samples were analyzed video to determine exact knee angle of valgus. During the second stage, to which players with valgus knee were qualified (≥15˚), the Y-Balance Test was additionally used. Intervention group underwent an exercise program to strengthen gluteus medius, popliteal and tibialis posterior muscles for 6 weeks to repeat tests in the third stage. Results Statistical methods used at the assumed level of significance allow to conclude that there are no differences in results of dynamic valgus (≥15˚) and dynamic balance between the intervention group and control group during the 6 week period between stages. In addition, there were results confirming the lack of influence of length and dominant lower limb on valgus. Results of composite direction in the Y-Balance Test test determine the low risk of injury in both intervention and control groups. Conclusions Intervention did not affect the dynamic valgus and knee balance in young football players. Both the length and the dominant limb did not affect the results. The "low risk" occurrence of injuries among the examined participants with valgus knee due to the values of dynamic balance was determined.
Simulation via Instant Messaging-Birmingham Advance (SIMBA) model helped improve clinicians’ confidence to manage cases in diabetes and endocrinology
Authors: Melson Eka , Davitadze Meri , Aftab Manal , Ng Cai Ying , Ooi Emma , Blaggan Parisha , Chen Wentin , Hanania Thia , Thomas Lucretia , Zhou Dengyi , Chandan Joht Singh , Senthil Latha , Arlt Wiebke , Sankar Sailesh , Ayuk John , Karamat Muhammad Ali , Kempegowda Punith 
Published: December 2019

Abstract
Background: Simulation-based learning (SBL) has been increasingly used in both undergraduate and postgraduate medical training curricula. The aim of Simulation via Instant Messaging-Birmingham Advance (SIMBA) is to create a simple virtual learning environment to improve trainees’ self-reported confidence in diabetes and Endocrinology. Methods: This study was done as part of the continuous professional development for Health Education England West Midlands specialty trainees in diabetes and Endocrinology. Standardized transcripts of anonymized real-life endocrinology (endocrine session) and diabetes cases (diabetes session) were used in the simulation model. Trainees interacted with moderators through WhatsApp® in this model. All cases were then discussed in detail by a consultant endocrinologist with reference to local, national and international guidelines. Trainee acceptance rate and improvement in their self-reported confidence levels post-simulation were assessed. Results: 70.8% (n=17/24) and 75% (n=18/24) strongly agreed the simulation session accommodated their personal learning style and the session was engaging. 66.7% (n=16/24) strongly felt that the simulation was worth their time. In endocrine session, there was a significant improvement in trainees’ confidence in the management of craniopharyngioma (p=0.0179) and acromegaly (p=0.0025). There was a trend towards improved confidence levels to manage Cushing’s disease and macroprolactinoma. In diabetes session, there was a significant improvement in trainees’ confidence to interpret continuous glucose monitor readings (p = 0.01). There was a trend towards improvement for managing monogenic diabetes, hypoglycaemic unawareness and interpreting Libre readings. Overall, there was a significant improvement in trainees’ confidence in managing cases that were discussed post-simulation. Conclusion: SIMBA is an effective learning model to improve trainees’ confidence to manage various diabetes and endocrine case scenarios. More sessions with a variety of other specialty case scenarios is needed to further assess SIMBA’s effectiveness and application in other areas of medical training.
The Collaborative Learning Development Exercise (CLeD-EX): an educational instrument promoting key collaborative learning behaviours in medical students
Authors: Iqbal Maha Pervaz , Velan Gary M , Sullivan Anthony O’ Sullivan J O’ , Balasooriya Chinthaka 
Published: December 2019

Abstract
Background: Modern clinical practice increasingly relies on collaborative and team-based approaches to care. Regulatory bodies in medical education emphasise the need to develop collaborative and teamwork competencies and highlight the need to do so from an early stage of medical training. During undergraduate medical education the focus is usually to facilitate collaborative learning and increase feedback and reflection on this learning. This article describes a novel educational instrument, the Collaborative Learning Development Exercise (CLeD-EX), which aims to foster the development of key collaborative learning competencies in medical students. Methods: In this study, the “educational design research” framework was used to develop, implement and evaluate the CLeD-EX. This involved adopting a systematic approach towards designing a creative and innovative instrument which would help solve a real-world challenge in developing collaborative learning skills. The systematic approach involved a qualitative exploration of key collaborative learning behaviours which are influential in effective collaborative learning contexts. The identified competencies were employed in the design of the CLeD-EX. The design of the CLeD-EX included features to facilitate structured feedback by tutors to students, complemented by self-evaluation and reflection. The CLeD-EX was field-tested with volunteer junior medical students, using a controlled pre-test post-test design. Analysis of the completed CLeD-EX forms, self-perception surveys (i.e. pre-test and post-test surveys) and analyses of reflective reports were used to explore the educational impact of CLeD-EX, as well as its utility and practicality. Results: After using the CLeD-EX, students showed a significant improvement in self‑directed learning, critical thinking and group process as measured by a previously validated instrument. Both students and tutors recognised CLeD-EX as an effective instrument, especially as a structured basis for giving and receiving feedback and for completing the feedback loop. CLeD-EX was also found to be feasible, practical and focused, while promoting learning and effective interactions in small group learning. Conclusion: The findings of this study support the introduction of an educational instrument such as the CLeD-EX to facilitate the development of students’ skills in collaborative learning.
Barriers to improved orofacial pain practice in Saudi Arabia
Authors: hadlaq emad mohammed 
Published: December 2019

Abstract
Background: Orofacial pain (OFP), an emerging field in dentistry, is associated with evaluation diagnosis, and treatment of non-odontogenic disorders affecting the mouth, jaws and face. The aim of this study was to investigate the barriers encountered by Saudi dentists engaged in OFP practice. Methods: A cross-sectional survey study was performed using a validated closed-end questionnaire that was distributed to the general dental practitioners (GDPs) and dental specialists in four major provinces in Saudi Arabia: Riyadh, Makkah, Asir, and Eastern Province. Inclusion criteria were registration with the Saudi Commission for Health Specialties and a minimum of 2 years’ experience. The collected data were analysed using descriptive parameters. Results: Three-hundred-and-forty questionnaires were completed by 168 males and 172 females. Around two-third of the participants were GDPs (60.9%), and the remainder were dental specialists. There was an obvious consensus by the participants that "Low payment/reimbursement" and “Lack of OFP knowledge” were among the most common barriers (85% and 83.5%, respectively; both P-value < 0.01). In contrast, "Legal risks" was the least frequently reported factor (38.8%; P-value < 0.01). The most commonly reported barrier by GPDs was “Shortage of patients/lack of demand;” this was significantly different from the experience of dental specialists (87% vs. 72.2%; P- value < 0.01). In terms of the country of graduation or years of experience, there were no significant differences Conclusion: The current study demonstrates the existence of many significant barriers other than OFP knowledge, such as reimbursement, facility, and demand that could present obstacles and challenges to the management of OFP by dentists. Most participants believed that dentists should manage this condition and that OFP courses should be included in dental schools’ curricula Keywords: barriers, clinical research study, dentist, orofacial pain, recommendations, survey
Buoyant rise of anorthosite from a layered basic complex triggered by Rayleigh-Taylor instability: Insights from a numerical modeling study
Authors: Mukherjee Amal Bikash , Das Subhasish , Sen Dhrubajyoti , Bhattacharya Bikramjit 
Published: December 2019

AbstractA major unsolved problem of the Proterozoic is the genesis and tectonic evolution of the massif type anorthosites. The idea of large-scale floating of plagioclase crystals in a basaltic magma chamber eventually generating massif type anorthosite diapirs from the floatation cumulates is not supported by observations of the major layered basic complexes of Proterozoic to Eocene age. In this paper, we test and propose a new genetic process of anorthosite diapirism through Rayleigh-Taylor instability. We have carried out a numerical modeling study of parallel, horizontal, multiple layers of norite and anorthosite, in a model layered basic complex, behaving like Newtonian or non-Newtonian power law fluids in a jelly sandwich model of the continental lithosphere. We have shown that in this pressure-temperature-rheology configuration the model lithosphere generates Rayleigh-Taylor instability, which triggers diapirism of the anorthosite. In our model, the anorthosite diapirs buoyantly rise through stages of simple, symmetrical upwelling and pronounced bulbous growth to a full-blown mushroom-like form. This is the growth path of diapirs in nearly all analog and numerical previous studies on diapirism. Our anorthosite diapirs fully conform to this path. Furthermore, we demonstrate that the progressive diapirism brings in striking internal changes within the diapir itself. In the process, the lowermost anorthosite layer rises displacing the upper norite and anorthosite layers as progressively stretched and isolated segments driven to the margin of the rising diapir—a feature commonly seen in natural anorthosite massifs. We propose that a large plume-generated basaltic magma chamber may be ponded at the viscous lower crust or ductile-plastic upper mantle or further down in the weaker mantle of the jelly sandwich type continental lithosphere. The magma may cool and crystallize very slowly and resolve into a thick-layered basic complex with anorthosite layers. Rheologically behaving like Newtonian or non-Newtonian power law fluids, the layers of the basic complex with built-in density inversions would generate RT (Rayleigh-Taylor) instability. The RT instability would trigger a buoyant rise of the unstable anorthosite from the layered complex. The upward driven anorthosite, accumulated as anorthosite plutons, would gradually ascend across the lower and middle crust as anorthosite diapirs.
Rancang Bangun Bimbingan Konseling Online
Authors: Wibowo Nur Cahyo Hendro , Milenia Flora Ima , Azmi Faris Hifzhuddin 
Published: December 2019

<p>Zaman globalisasi ditandai dengan fenomena teknologi informasi dan telekomunikasi yang menunjang disegala bidang. Fenomena teknologi informasi dan telekomunikasi <em>(Information and Communication technology / ICT)</em> tersebut bagi masyarakat global (dunia) kemudian menciptakan suatu kecenderungan paradigma masyarakat terbuka, yaitu suatu kenyataan dimana tidak ada sekat dan batas yang menghalangi untuk saling berinteraksi. Perkembangan ilmu pengetahuan dan teknologi telah membawa manusia menuju peradaban modern, suatu peradaban yang ditandai dengan banyak dimanfaatkannya teknologi untuk membantu aktifitas manusia.</p>Lebih lanjut dalam Wikipedia, online adalah dimaknai dalam jaringan atau daring atau keadaan saat sesuatu terhubung ke dalam suatu jaringan atau system (umumnya internet atau ethernet). Jadi istilah konseling online dapat dimaknai secara sederhana yaitu proses konseling yang dilakukan dengan alat bantu jaringan sebagai penghubung antara guru bk/konselor dengan kliennya. Hal ini senada dengan yang dikemukakan oleh (Amani, 2007) Konseling Online adalah konseling melalui internet yang secara umum merujuk pada profesi yang berkaitan dengan layanan kesehatan mental melalui teknologi komunikasi internet. Lebih lanjut Fields (2011) menyebutkan bahwa konseling online adalah layanan terapi yang relatif baru. Konseling dikembangkan dengan menggunakan teknologi komunikasi dari yang paling sederhana menggunakan email, sesi dengan chat, sesi dengan telp pc-to-pc sampai penggunaan dengan penggunaan webcam (video live sessions), yang secara jelas menggunakan komputer dan internet. Haberstroh (2011) menjelaskan bahwa konseling online adalah klien dan konselor berkomunikasi dengan menggunakan streaming video dan audio. Capill (tt). Counselling using the computer as the medium of communication between client and counsellor. Dari beberapa pendapat di atas dapat dipahami dan disimpulkan bahwa konseling online adalah usaha membantu (therapeutic) terhadap klien/konseli dilakukan dengan memanfaatkan teknologi informasi, komputer dan internet.
MIKROENKAPSULASI EKSTRAK KULIT BUAH NAGA MERAH DENGAN TEKNIK SPRAY DRYING
Authors: Sofyaningsih Mira , Iswahyudi Iswahyudi 
Published: December 2019

Penggunaan pewarna sintetis dan pewarna yang dilarang, karena memiliki efek negatif bagi kesehatan, masih marak dijumpai dalam produksi makanan dan minuman. Kulit buah naga merah yang selama ini merupakan limbah, dapat dimanfaatkan untuk produksi pewarna alami karena proporsi kulit tersebut cukup besar dan mengandung pigmen antosianin. Tujuan penelitian ini adalah mempelajari cara mikroenkapsulasi ekstrak kulit buah naga merah menggunakan maltodekstrin DE10-12 dengan teknik spray drying. Proses spray drying dilakukan pada suhu inlet 150-160ºC dan suhu outlet 70-80ºC serta konsentrasi maltodekstrin DE10-12 sebesar 10, 15, dan 20%. Dari hasil penelitian diketahui bahwa konsentrasi 20% memiliki rendemen tertinggi (40,59%), kadar air terendah (4,67%), dan tingkat kecerahan tertinggi (76,77).
Kata kunci: Kadar Air, Kecerahan Warna, Kulit Buah Naga Merah, Mikroenkapsulasi, Rendemen