bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic association of primary non-response to Anti-TNFα therapy in patients with Inflammatory Bowel Disease
Authors: De T. , Zhang H. , Alarcon C. , Lec B. , Avitia J. , Smithberger E. , Chen Chuyu , Horvath M. , Kwan S. , Young M. , Adhikari S. , Kwon J. H. , Pacheco J. , Jarvik G.P. , Wei W. , Mentch F. , Hakonarson H. , Sleiman P. , Gordon A.S. , Harley J. , Linneman J. G. , Hebbring S. , Parisiadou L. , Perera M. A. 
Published: June 2020

AbstractBackground & AimsPrimary non-response (PNR) to anti-tumor necrosis factor-α (TNFα) biologics is a serious concern in patients with inflammatory bowel disease (IBD). We aimed to identify the genetic variants associated with PNR.MethodsPatients were recruited from outpatient GI clinics and PNR was determined using both clinical and endoscopic findings. A case-control genome-wide association study was performed in 589 IBD patients and associations were replicated in an independent cohort of 293 patients. Effect of the associated variant on gene expression and TNFα secretion was assessed by cell-based assays. Pleiotropic effects were investigated by Phenome-wide Association Study (PheWAS).ResultsWe identified rs34767465 as associated with PNR to anti-TNF-α therapy (OR:2.07, 95%CI:1.46-2.94, p=2.43×10−7, [Replication OR:1.8, 95%CI:1.04-3.16, p=0.03]). rs34767465 is a multiple-tissue expression quantitative trait loci for FAM114A2. Using RNA-sequencing and protein quantification from HapMap lymphoblastoid cell lines (LCLs), we found a significant decrease in FAM114A2 mRNA and protein expression in both heterozygous and homozygous genotypes when compared to wild type LCLs. TNF-α secretion was significantly higher in THP-1 cells [differentiated into macrophages] with FAM114A2 knockdown versus controls. Immunoblotting experiments showed that depletion of FAM114A2 impaired autophagy related pathway genes suggesting autophagy mediated TNF-α secretion as a potential mechanism. PheWAS showed rs34767465 was associated with comorbid conditions found in IBD patients (derangement of joints [p=2.3×10−4], pigmentary iris degeneration [p=5.1×10−4], diverticulum of esophagus [p=6.3×10−4]).ConclusionWe identified a variant rs34767465 associated with PNR to anti-TNFα biologics, which increases TNFα secretion through mechanism related to autophagy. rs34767465 may also explain the comorbidities associated with IBD.
Mutant glucocorticoid receptor binding elements on Interleukin-6 promoter regulate dexamethasone effects
Authors: Chang Wen-Teng , Hong Ming-Yuan , Chen Chien-Liang , Tsai Cheng-Chieh , Hwang Chi-Yuan , Chuang Chia-Chang 
Published: June 2020

AbstractGlucocorticoid has been widely used as an important modulator for clinical infectious and inflammatory disease. Glucocorticoid receptor (GR) is a transcription factor belonging to the family of nuclear receptors, regulated anti-inflammatory process and the release of pro-inflammatory cytokines. Five putative GR and other transcription factor binding sites on interleukin (IL)-6 promoter were identified and dexamethasone could reduce LPS-induced IL-6 release. Among them, the mutant transcriptional factors NF-κB, AP-1, and Sp1-2 site decreased the basal and effects of lipopolysaccharide (LPS)-induced IL-6 promoter activities in different responses. GR2/3 seemed to be an important role in both basal and inducible promoter activities in LPS-induced inflammation. We concluded that the selective GR2/3 modulators may have agonistic and antagonistic combined effects and activate important signaling pathway during LPS-stimulated inflammatory process.
Incidence, Risk Factors and Mortality Outcome in Patients with Acute Kidney Injury in COVID-19: A Single-Center Observational Study
Authors: Gaetano Alfano , Annachiara Ferrari , Francesco Fontana , Giacomo Mori , Riccardo Magistroni , Marianna Meschiari , Erica Franceschini , Marianna Menozzi , Gianluca Cuomo , Gabriella Orlando , Antonella Santoro , Margherita Di Gaetano , Cinzia Puzzolante , Federica Carli , Andrea Bedini , Jovana Milic , Paolo Raggi , Massimo Girardis , Cristina Mussini , Gianni Cappelli , Giovanni Guaraldi ,   for the Modena Covid-19 Working Group (MoCo19)
Published: June 2020

AbstractBackgroundAcute kidney injury (AKI) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI in patients with documented COVID-19.MethodsWe reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy.ResultsAKI was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI patients had a mean age of 74.7±9.9 years and higher serum levels of the main marker of inflammation and organ involvement (lung, liver, hearth and liver) than non-AKI patients. AKI events were more frequent in subjects with severe lung comprise. Two peaks of AKI events coincided with in-hospital admission and death of the patients. Kidney injury was associate with a higher rate of urinary abnormalities including proteinuria (0.448±0.85 vs 0.18±0.29; P=<0.0001) and hematuria (P=0.032) compared to non-AKI patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI. Risk factors for kidney injury were age, male sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI was independently associated with in-hospital death (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non-AKI patients. Groups of patients with AKI stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine, likely due to muscle depletion occurred with prolonged bed rest.ConclusionsAKI was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI and prevention of kidney injury by avoiding dehydration and nephrotoxic agents is imperative in this vulnerable cohort of patients.
Randomized Re-Opening of Training Facilities during the COVID-19 pandemic
Authors:   The TRAiN study group, Helsingen Lise M. , Løberg Magnus , Refsum Erle , Gjøstein Dagrun Kyte , Wieszczy Paulina , Olsvik Ørjan , Juul Frederik E. , Barua Ishita , Jodal Henriette C. , Herfindal Magnhild , Mori Yuichi , Jore Solveig , Lund-Johansen Fridtjof , Fretheim Atle , Bretthauer Michael , Kalager Mette 
Published: June 2020

AbstractBackgroundMost countries closed training facilities during the COVID-19 pandemic. This may have negative consequences for people’s health and wellbeing. We investigated SARS-CoV-2 virus transmission and COVID-19 disease attributable to training facilities.MethodsWe randomized members 18 to 64 years with no COVID-19 relevant comorbidities randomized Five training facilities in Oslo, Norway to access or no access to their training facility. Facilities were opened from May 22, 2020 for individuals randomized to training, applying increased social distancing (1 meter for floor exercise, 2 meters for high-intensity classes), enhanced hand and surface hygiene. Locker rooms were open, showers and saunas were closed. We measured SARS-CoV-2 PCR status by self-administered naso-, oropharyngeal and sputum sampling after two weeks and clinical disease by linkage to electronic patient records after three weeks.Results3,764 individuals were randomized and included in analyses; 1,896 in the training and 1,868 in no-training arms. In the training arm, 81.8% trained at least once at the facilities, and 38.5% trained ≥six times. Out of 3,016 individuals who returned the SARS-CoV-2 PCR tests (80.5%), there was one positive test. The positive individual was randomized to training, but had not used the facility before testing day. Contact tracing revealed the workplace as transmission source. A total of 106 individuals (2.8%) had outpatient hospital visits, and six individuals were admitted to hospital during the three weeks after intervention start, with no differences between arms. There were no outpatient visits or hospital admissions due to COVID-19 in either group.ConclusionsProvided good hygiene and social distancing measures, there was no increased COVID-19 spread at training facilities. NCT04406909
Seroprevalence of SARS-CoV-2 significantly varies with age: preliminary results from a mass population screening
Authors: Pagani Gabriele , Conti Federico , Giacomelli Andrea , Bernacchia Dario , Rondanin Rossana , Prina Andrea , Scolari Vittore , Gandolfi Cecilia Eugenia , Castaldi Silvana , Marano Giuseppe , Ottomano Cosimo , Boracchi Patrizia , Biganzoli Elia , Galli Massimo 
Published: June 2020

AbstractObjectivesCastiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass seroprevalence screening.MethodsWe searched for SARS-CoV-2 IgGs in the entire voluntary population using lateral flow immune-cromatographic tests on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs in a randomized representative sample of 562 subjects and in every subject with a positive rapid test.ResultsBased on CLIA serologies on the representative random sample (509 subjects), we estimated a 23% IgG seroprevalence. We also found a strong correlation between age and prevalence, with the elderly showing the highest probability of a positive serological test.ConclusionsIn an area of unrestricted viral circulation less than one-fourth of the population tested positive for SARS-CoV-2 IgG. Seroprevalence increased with increasing age, possibly suggesting differences in susceptibility to the infection.
Effect of different laser energy densities on the corrosion resistance of aluminum alloys
Authors: Xie Di , Chen Hui , Yin Siyi , Wang Feisen , Chen Jingwen , Ai Sifei 
Published: June 2020

Purpose
Laser cleaning, as a new type of cleaning technology, has the advantages of environment-friendliness, better selectivity, better controllability and higher efficiency compared to traditional chemical cleaning or grinding. This paper aims to use ultra-fast surface laser cleaning equipment built in laboratory to study the influence of different energy density (7.6, 11.5 and 15.3 J/cm2) on corrosion resistance of the aluminum alloy A7N01P-T4, a high-speed train body material.

Design/methodology/approach
SEM, white light interferometer, EDS and XPS were used to analyze the surface morphology, roughness, element content and oxide layer composition of aluminum alloy before and after cleaning. The corrosion resistance was studied by electrochemical experiments and exfoliation corrosion experiments.

Findings
The results showed that new oxide scale was formed on the surface after laser cleaning. The changes of surface roughness and chemical composition of oxide scale made a significant influence on corrosion behaviors. Better corrosion resistance was obtained with the energy density increased, and at the energy density of 11.5 J/cm2, aluminum alloy exhibited the best corrosion resistance.

Research limitations/implications
The paper only studies specific aluminum alloys and is not universal. Laser cleaning equipment is set up for the laboratory and has not yet been put into industrial production.

Practical implications
This paper indicated that ultra-fast laser processing was a new direction for the development of industrial equipment surface cleaning and carried out ultra-fast laser of aluminum alloy surface cleaning had certain research significance for its corrosion resistance.

Social implications
Compared with the conventional cleaning methods such as air abrasives grinding or chemical cleaning, laser cleaning has advantages of environment-friendliness, better selectivity, better controllability and higher efficiency. Laser cleaning can not only protect the environment, but also improve cleaning efficiency.

Originality/value
Changes in the surface of aluminum alloys after ultra-fast surface laser treatment were found, and the mechanism of changes in aluminum alloy corrosion properties was clarified.
Identifying organizational variables to the implementation of horizontal strategy in conglomerates
Authors: Verma Pratima , Sharma R.R.K. , Kumar Vimal , Hsu Sung Chi , Lai Kuei-Kuei 
Published: June 2020

PurposeThe paper aims to investigate organizational variables and develop their relationship with horizontal strategy. The cultural dimensions and organization structure have been considered as organizational variables. The study also aims to shed light on the implementation horizontal strategy in conglomerates.Design/methodology/approachA survey was carried out with 122 conglomerate firms for examination. These companies were chosen to be of different sizes and sectors. The multiple regression analysis was utilized to analyze the data.FindingsThe results reveal that conglomerate firms also have a horizontal strategy. Additionally, organizational cultural dimensions namely, collectivism, clan culture, market culture and long-term orientation; formal and informal relationship; and horizontal organization structure (HOS) have positive and significant relationship with horizontal strategy. No significant relationship was found between uncertainty avoidance and adhocracy culture, and horizontal strategy.Research limitations/implicationsThe major contributions of this study are explicitly identified as horizontal strategy exists in the conglomerate firms where the few organizational variables play a significant role in horizontal strategy implementation.Originality/valueThis study has been done in an effort to make supporting guidelines to fill the gaps in conglomerate firms. This study offers an effective role of cultural dimensions and structure as drivers of horizontal strategy implementation, and this study spells out and extends the literature and proposes a conceptual framework.
How to prevent a global food and nutrition security crisis under COVID-19?
Authors: Fan Shenggen , Si Wei , Zhang Yumei 
Published: June 2020

PurposeThe purposes of this paper are to review the impact on food and nutrition security of several pandemic emergencies and the 2018 food price crisis from a global perspective, examine the Chinese experiences and lessons in ensuring food and nutrition security for its citizen and propose policy actions to prevent a global food and nutrition security crisis.Design/methodology/approachThe authors utilize a noncomprehensive review of peer-reviewed and nonpeer-reviewed literature, as well as a case study approach.FindingsUnder the ongoing COVID-19, China's food and nutrition are relatively secure in short run largely due to governmental proactive policies but may face uncertainties in livestock production and imports of soybean in the medium and long terms. Given that the disease has spread to almost all countries in the world, global cooperation and coordination are needed to prevent systemic risks to global food and nutrition security.Practical implicationsThe review and analysis of this paper will help policymakers in China and other countries to design strategies and actions to prevent food and nutrition security crisis under the ongoing COVID-19 emergency and other similar threats in the future.Originality/valueThis paper provides recommendations to prevent food and nutrition security crisis based on data, evidence and case studies.
Overcoming hierarchy in business model innovation: an actor-oriented approach
Authors: Di Toma Paolo , Ghinoi Stefano 
Published: June 2020

PurposeBusiness model innovation is a key element for firms' competitiveness. Its development can be supported by the establishment of an actor-oriented scheme to overcome hierarchical structures. The actor-oriented scheme is characterized by intra-organizational networks of relationships that can be established and dissolved between individuals. However, we lack an empirical perspective about its establishment; therefore, the purpose of this research is to advance our understanding of intra-organizational networks for supporting business model innovation.Design/methodology/approachIndividuals create and manage knowledge aimed to innovate the business model through cognitive search and experiential learning mechanisms. Knowledge is spread within organizations by using intra-organizational advice networks, whose patterns reflect the presence of an actor-oriented scheme. This work applies social network analysis to network data from a multi-unit organization specializing in personal care services. We use a Logistic Regression-Quadratic Assignment Procedure to analyze intra-organizational network data on managers' advice exchange related to the learning modes of cognitive search and experiential learning.FindingsOur research empirically identifies the main elements of an actor-oriented scheme in a business model innovation process. We find that managers are able to self-organize, because they are not influenced by their organizational roles, and that commons for sharing resources and protocols, processes and infrastructures enable advice exchange, thus showing the presence of an actor-oriented scheme in business model innovation process.Research limitations/implicationsThis research is based on a cross-sectional database. A longitudinal study would provide a better understanding of the network evolution characterizing the innovation process.Practical implicationsThe results of our study support organizational decision-making for business model innovation.Originality/valueThis study provides empirical evidence of how an actor-oriented scheme emerges in a business model innovation process.
Measuring the impact of human resource management (HRM) practices on pharmaceutical industry's effectiveness: the mediating role of employee competencies
Authors: Otoo Frank Nana Kweku 
Published: June 2020

PurposeThe aim of this paper is to examine the mediating role of employee competencies in the association between human resource management (HRM) practices and organizational effectiveness of the pharmaceutical industry in Ghana.Design/methodology/approachAn integrated research model was developed by combining principal factors from existing literature. The validity of the model was tested by applying structural equation modelling (SEM) to the data collected from 550 employees of the selected pharmaceutical industries. The reliability and validity of the dimensions are established through confirmatory factor analysis (CFA) and related hypotheses tested using SEM.FindingsThe results indicate that some HRM practices influence organizational effectiveness through their impact on employee competencies. The study further revealed that employee competencies mediate the association between HRM practices and organizational effectiveness.Research limitations/implicationsThe research was undertaken in the pharmaceutical industry and the analysis based on cross-sectional data which cannot be generalized across a broader range of sectors and international environment.Practical implicationsThe findings of the study have the potential to help stakeholders, policy makers and management of the pharmaceutical industry in espousing suitable and well-articulated HRM practices to influence and shape the skills, knowledge and behaviour of employees and inordinately enhance organizational effectiveness.Originality/valueThis study extends the literature by adducing evidence empirically that employee competencies mediated the association between HRM practices and organizational effectiveness of the pharmaceutical industry in Ghana.
Participatory action research in schools: unpacking the lived inequities of high stakes testing
Authors: DeJaynes Tiffany , Cortes Tabatha , Hoque Israt 
Published: June 2020

PurposeThis paper aims to examine a school-based Youth Participatory Action Research (YPAR) project on educational inequity and high stakes testing.Design/methodology/approachA former high school teacher (currently a university professor) and two former students (currently research assistants and university students) take up a youth studies framework to collaboratively resee multimodal artifacts from a tenth-grade course in qualitative research.FindingsFindings illustrate the power of finding allies in peers and educators; the transformative power of deep participation; and the longitudinal nature of social change and action. Thus, this research demonstrates that when students are positioned as researchers, experts and knowledge producers, they can collaborate with one another, teachers and administrators to confront social inequities within their schools and beyond.Originality/valueThis study has value for applying critical, youth-centered pedagogies in secondary English language arts classrooms and schools.
Perceived vulnerability of cyberbullying on social networking sites: effects of security measures, addiction and self-disclosure
Authors: Jain Shilpi , Agrawal Soni 
Published: June 2020

Purpose
Cyber-bullying is a form of cyber-crime that has been propagated through extensive use of social networking sites (SNS). Despite the implementation of sophisticated security measures and government compliances, privacy intrusion is petrifying. Therefore, the purpose of this paper attempts to explore as follows: why cases of bullying are still snowballing year after year? Is it possible that advances in security measures are making users more vulnerable? Or, is it a social media addiction, which is making users vulnerable to cyberbullying?

Design/methodology/approach
The proposed research framework is grounded in the technology threat avoidance theory (TTAT). An empirical survey of 365 social media users was analysed using structural equation modelling (SEM) to understand the impact of security measures, voluntary self-disclosure (VSD) and addiction on perceived vulnerability (PV) to cyber-bullying.

Findings
The findings indicate that security measures play a significant role in propelling users to disclose their personal information voluntarily, which, in turn, results in social media addiction, which further exposes users to cyberbullying. Moreover, the study unravels gender differences in perceived vulnerabilities to cyberbullying.

Practical implications
The findings of the current research contribute to a better understanding of gender differences in the awareness of security measures, addiction intensities, level of self-disclosures and propensity to cyberbullying victimization. Additionally, prevention and intervention efforts may benefit from using a more targeted approach to identify potential male and female victims that experience different forms of bullying on SNS.

Originality/value
In addition to other constructs, the current research investigates the role of user security measures (USM) and website security measures (WSM) on the PV to cyberbullying, typically, the role of these measures is to prevent the users from becoming the victims, whereas the research unravels that they could be the possible reasons for the increased number of cases in India. To the best of the knowledge, such conflicting roles of security measures have not been discussed earlier.