bluuebunny/crossref_metadata_2025_split huggingface dataset:
“OK, So you Think It’s All About Work Engagement?” Exploring Precursors and Outcomes of Work Engagement Among Healthcare Professionals
Authors: Slåtten Terje , Lien Gudbrand 
Published: June 2020

Abstract
Background: Health services organizations need to understand how they best can achieve important organizational goals such as lowering healthcare professionals’ turnover intentions, increase their job satisfaction and level of service quality provided to patients. This study aims to test whether work engagement of healthcare professionals is a core factor in the achievement of these preferred organizational goals. The study also aims to explore whether work engagement is manageable through the direct impact of organizational culture and climate and indirectly for the accomplishment of organizational goals.Methods: The proposed conceptual model was tested in a quantitative study where healthcare professionals, in this study represented by the group of hospital nurses, participated. The data were analyzed using confirmatory factor analysis and structural equation modeling in Stata.Results: The results can be divided into three sub-results. First, work engagement of health professionals was found to be positively related to service quality of care (b = 0.551) and job satisfaction (b = 0.883). Job satisfaction fully mediates the relationship between work engagement and turnover intention and in itself explains almost 60% (R2 = 0.59) of turnover intentions. Second, health professionals’ perception of organizational culture (b = 0.278) and collaboration climate (b = 0.331) were both directly related to their work engagement. Third, work engagement fully mediates the relationship between organizational culture, organizational climate and service quality of care and job satisfaction. Moreover, work engagement particularly mediates the relationship between collaborative climate and job satisfaction.Conclusions: This study contributes to extending and deepening previous research on work engagement in health services research. Specifically, it reveals the essential role that work engagement of healthcare professionals plays for the achievement of organizational goals. Consequently, leaders and managers of healthcare organizations should have a serious focus on health professionals’ work engagement and put it on their meeting agenda regularly because it is clearly a core driver to enabling multiple desirable outcomes for healthcare organizations.
Export Diversification and Economic Growth in the United Arab Emirates: An Empirical Investigation
Authors: SHADAB SAIMA 
Published: June 2020

Abstract
Using the Vector Error Correction Model and Toda-Yamamoto Causality approach, this paper investigates the short-run and long-run relationship between export diversification, physical and human capital, imports, and economic growth in the UAE. The study period in consideration is 1975-2017. The findings obtained from the VECM test confirm the existence of a significant long-run relationship between export diversification, imports, and economic growth in the UAE. Besides, the Toda Yamamoto Granger Causality test results reveal that imports Granger-cause UAE’s economic growth which proves the validity of the Import-Led Growth hypothesis for the UAE economy in the long-run. The results also confirm that a unidirectional causal relationship exists from export diversification to economic growth for the UAE. This finding indicates the success of the UAE economy in attaining economic diversification and reduction from oil-dependency.
Association Between CYP2C19 Polymorphisms and Esophageal Squamous Cell Carcinoma Risk in Asian Populations: A Systematic Review and Meta-analysis
Authors: Gao Xuehan , Wang Guige , Liu Lei , Zhang Jiaqi , Zhao Ke , Wang Yanqing , Li Shanqing 
Published: June 2020

Abstract
Background: This meta-analysis was performed to evaluate the association between CYP2C19 gene polymorphisms and ESCC risk in Asian populations.Methods: A literature search was performed in main medical publication databases for the association between CYP2C19 gene polymorphisms and ESCC risk, up to May 2020. A random/fixed-effects model was used to calculate the pooled odds ratios (OR) and 95% confidence intervals (CI) to evaluate the associations, considering multiple genetic models. And people were classified into three groups according to metabolizer phenotypes: (i) extensive metabolizers (EMs: *1/*1, *1/*2, *1/*3); (ii) intermediate metabolizers (IMs: *1/*2, *1/*3) and (iii) poor metabolizers (PMs: *2/*2, *2/*3, *3/*3).Results: Eight studies with 1955 cases and 2754 controls were ultimately included that showed that individuals carrying the “A” allele of CYP2C19*2 G681A and AA genotype of CYP2C19*3 G636A were significantly associated with an increased ESCC risk (CYP2C19*2 A vs. G: OR = 1.823, 95% CI = 1.616-2.056; CYP2C19*3 AA vs. AG + GG: OR = 2.992, 95% CI = 1.122-7.981). In the analysis of metabolizer phenotypes, PMs and IMs groups were associated with ESCC risk compared to EMs (IMs vs. EMs: OR = 1.673, 95% CI = 1.281-2.186; PMs vs. EMs: OR = 2.605, 95% CI = 1.945-3.489). And PMs showed a stronger correlation (PMs vs. IMs + EMs: OR = 2.220, 95% CI = 1.705-2.891).Results: Eight studies with 1955 cases and 2754 controls were ultimately included that showed that individuals carrying the “A” allele of CYP2C19*2 G861A and AA genotype of CYP2C19*3 G636A were significantly associated with an increased ESCC risk (CYP2C19*2 A vs. G: OR = 1.823, 95% CI = 1.616-2.056; CYP2C19*3 AA vs. AG + GG: OR = 2.992, 95% CI = 1.122-7.981). In the analysis of metabolizer phenotypes, PMs and IMs groups were associated with ESCC risk compared to EMs (IMs vs. EMs: OR = 1.673, 95% CI = 1.281-2.186; PMs vs. EMs: OR = 2.605, 95% CI = 1.945-3.489). And PMs showed a stronger correlation (PMs vs. IMs + EMs: OR = 2.220, 95% CI = 1.705-2.891).Conclusions: Our meta-analysis revealed that “A” allele (AA+AG) ofCYP2C19*2 and AA genotype of CYP2C19*3 polymorphism are significantly associated with ESCC risk. In metabolizer phenotypes, PMs and IMs are associated with an increased risk of ESCC in Asian populations.
High Dose Atorvastatin Raises Threshold of Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention.
Authors: Abdel-Galeel Ahmed , Elmaghraby Khaled , Ghaleb Ramadan , Hanafy Amr , Elsharef M Abdelfatah , Ibrahim Ayman 
Published: June 2020

Abstract
Background Contrast induced nephropathy (CIN) is a significant complication of angiographic procedures resulting from injection of iodinated contrast media (CM). Patients with diabetes mellitus (DM) are at the highest risk of CIN. Statins have recently been proposed for protection against CIN due to their antioxidant and anti-inflammatory propertiesAim of work To investigate the potential benefit of acute pretreatment with high dose atorvastatin (80 mg) in reduction of the incidence of CIN in diabetic patients indicated for elective coronary intervention.Patients and Methods 200 diabetic patients with indication for coronary intervention were enrolled in the study. 100 patients will be randomly assigned to receive atorvastatin (80 mg) just before coronary intervention (statin group) and 100 patients received placebo (control group). CIN was defined as a rise of serum creatinine of more than 25% or ≥0.5 mg/dl (44 μmol/l) from baseline within 48 hours of the angiography. After the procedure, TIMI flow of the culprit vessel was reported, as well as the volume of used contrast media and time of X-ray exposure.Results Our study reported a CIN incidence of 12, 18 and 6% among the whole study, placebo and statin groups respectively, p value 0.001. Among placebo group, CIN is likely to develop after 13.5 minutes X ray exposure time with specificity 73.2% and sensitivity 77.8%, AUC 0.879 (CI: 0.798-0.960), P value 0.001. While in statin group, CIN is likely to develop after 14.5 minutes X ray exposure time with specificity 74.5% and sensitivity 83.3%, AUC 0.818 (CI: 0.727-0.910), P value 0.009. In placebo group, CIN is likely to develop after injection of 145 ml with specificity 75.6% and sensitivity 77.8%, AUC 0.855 (CI: 0.757-0.952), P value 0.001. While in statin group, CIN is likely to develop after injection of 165 ml with specificity 84% and sensitivity 83.3%, AUC 0.878 (CI: 0.811-0.944), P value 0.002Conclusions Acute pre-treatment with high dose atorvastatin can effectively protect against CIN and was associated with a marked decrease in the prevalence of CIN in diabetic patients undergoing coronary interventions. Moreover, pre-treatment with high-dose atorvastatin raises the threshold of X-ray exposure time and amount of contrast media beyond which CIN is likely to develop.
Achilles Tendon Enthesitis Evaluated by MRI Assessments in Patients with Axial Spondyloarthritis and Psoriatic Arthritis: A Report of the Methodology of the ACHILLES Trial
Authors: Baraliakos Xenofon , Sewerin Philipp , de Miguel Eugenio , Pournara Effie , Kleinmond Christine , Wiedon Annette , Behrens Frank 
Published: June 2020

Abstract
Background: The currently available scoring methods for enthesitis are often measures of pain but not of inflammation at entheseal sites. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) psoriatic arthritis (PsA) magnetic resonance imaging (MRI) scoring system (PsAMRIS) assesses inflammation and damage in PsA and was particularly developed for the hands. The ACHILLES trial used clinical measures for heel enthesitis in combination with MRI scoring based on PsAMRIS.Methods: Patients (age ≥ 18 years) with spondyloarthritis (SpA) and PsA were included in the trial if they presented with clinical and MRI-positive heel enthesitis. MRI of the affected heel was performed at three time points: screening, Week 24 and Week 52. Inflammatory MRI findings (tendinitis, bursitis and bone marrow oedema [BME]) in the area of the Achilles tendon and/or plantar aponeurosis, periarticular inflammation of the ankle joint and heel erosion were assessed qualitatively (absent/present). In addition, BME and bone erosion were quantitatively assessed based on PsAMRIS, where their proportion was compared to the volume of the affected bone. Mean scores of BME and bone erosion quantification were calculated, and the mean composite score (based on PsAMRIS) was calculated based on the individual score of each subject for periarticular inflammation, BME and bone erosion and further extended for bursitis and tendinitis. Modifications to PsAMRIS were introduced by categorising oedema length as ≤/> 0.5 cm and locating bone erosion.Conclusions: In ACHILLES, MRI was used to assess and evaluate heel enthesitis. Due to the lack of a validated scoring system for heel enthesitis at the time of ACHILLES initiation, this trial applied quantitative scoring based on PsAMRIS, with specific adaptations for the heel.Trial registration: National Clinical Trial Registry, NCT02771210. Registered 13 May 2016. https://clinicaltrials.gov/ct2/show/NCT02771210?term=NCT02771210&draw=2&rank=1
Food related taboos and misconceptions during pregnancy among rural communities of Illu Aba Bor Zone, Southwest Ethiopia
Authors: Tsegaye Dereje , Tamiru Dessalegn , Belachew Tefera 
Published: June 2020

Abstract
Background: Poor maternal nutrition adversely affects pregnancy and birth outcomes. In many societies, pregnant women have food taboos and misconceptions which consequently results in the depletion of vital nutrients. These cultural malpractices and beliefs can influence dietary intake of pregnant women which subsequently affects the birth outcome. This study aimed at exploring the extent of food taboos and misconceptions during pregnancy in rural communities of Illu Aba Bor Zone, Southwest Ethiopia.Methods: A qualitative study was conducted using in-depth interviews of key informants and focus group discussions among purposefully selected pregnant women and their husbands, elderly people, health workers and health extension workers. Data were transcribed verbatim, thematized; color coded and analyzed manually using the thematic framework method.Result: Thorough reading and review of the transcripts generated three major themes. The first theme was belief and practice of taboos related to the intake of certain food items during pregnancy. Pregnant women, their husbands and mothers- in- law believed that certain foods should be avoided during pregnancy. The second theme was foods that were held as taboo and the reason attached to the food taboos. The most common food items held as taboo were related to the consumption of vegetables like cabbage, pumpkin, milk and milk products, sugar cane, fruit like banana and avocado and egg and the main reasons to avoid these foods were a belief that it can be plastered on the fetal head, making fatty baby which is difficult for delivery. The third theme was the reasons underlying adherence to food taboos which is deeply embedded in the personal believes and attitudes of the pregnant women, who were nested within the influence of the social environment surrounding them and the traditional beliefs and values of the society in general.Conclusions: The results showed a widespread practice of food taboo during pregnancy in the study area. The finding suggested that there is a need for strengthening the nutrition counseling components of antenatal care follow-up and planning comprehensive nutrition education through involving important others to dispel such traditional beliefs and prevent food taboo practices in the study community.
Postprandial Negatively Charged Very-Low-Density Lipoprotein ­Is a Novel Biomarker for Atrial Remodeling in Metabolic Syndrome
Authors: Lee Hsiang-Chun , Shin Shyi-Jang , Huang Jih-Kai , Lin Yu-Hsun , Ke Liang-Yin , Jiang He-Jiun , Tsai Wei-Chung , Chao Min-Fang , Lin Yi-Hsiung 
Published: June 2020

Abstract
Background: Negatively charged very-low-density lipoprotein (VLDL-χ) in metabolic syndrome (MetS) patients exerts cytotoxic effects on endothelial cells and atrial myocytes. Atrial cardiomyopathy, manifested by atrial remodeling with a dilated diameter, contributes to atrial fibrillation pathogenesis and predicts atrial fibrillation development. The correlation of VLDL-χ with atrial remodeling is unknown. This study investigated the association between VLDL-χ and left atrial dilatation. Methods: We evaluated 87 MetS and 80 non-MetS individuals between 23 and 74 years old (50.6% men) without overt cardiovascular diseases. Blood samples were collected while fasting and postprandially (at 0.5, 1, 2, and 4 hours after a unified meal). VLDL was isolated by ultracentrifugation; the percentile concentration of VLDL-χ (%) was determined by ultra-performance liquid chromatography. The correlations of left atrial diameter (LAD) with variables including VLDL-χ, LDL-C, HDL-C, triglycerides, glucose, and blood pressure, were analyzed by multiple linear regression models. A hierarchical linear model was conducted to test the independencies of each variable’s correlation with LAD. Results: The mean LAD was 3.4 ± 0.5 cm in non-MetS subjects and 3.9 ± 0.5 cm in MetS patients (P< 0.01). None of the fasting lipid profiles were associated with LAD. VLDL-χ, BMI, waist circumference, hip circumference, and blood pressure were positively correlated with LAD (all P<0.05) after adjustment for age and sex. We observed significant interactions between VLDL-χ and blood pressure, waist circumference, and hip circumference. When adjusted for obesity- and blood pressure-related variables, 2-hour postprandial VLDL-χ (mean 1.30 ± 0.61%) showed a positive correlation with LAD in MetS patients. Each 1% VLDL-χ increase was estimated to increase LAD by 0.62 cm. Conclusion: Postprandial VLDL-χ is associated with atrial remodeling. VLDL-χ is a novel biomarker for atrial cardiomyopathy in MetS patients and may be a therapeutic target. Trial registration: ISRCTN 69295295. Registered 9 June 2020.
15q26 Deletion in a Patient with Congenital Heart Defect, Growth Restriction and Intellectual Disability: Case Report and Literature Review
Authors: BENBOUCHTA Yahya , de Leeuw Nicole , Amasdl Saadia , Sbiti Aziza , Smeets Dominique , Sadki Khalid , Sefiani Abdelaziz 
Published: June 2020

Abstract
Background 15q26 deletion is a relatively rare chromosomal disorder described in only few cases. Patients with this aberration display numerous symptoms particularly pre- and postnatal growth restriction, microcephaly, intellectual disability, dysmorphic gestalt, and various congenital malformations. Case presentation We report on a girl, four years old, of consanguineous parents, with a de novo 15q26 deletion. Clinical manifestations included failure to thrive, microcephaly, dysmorphic facies with broad forehead, hypertelorism, narrowed eyelid slits, protruding columella. The patient also showed skeletal abnormalities, especially clinodactyly of the 5th finger, right foot varus equine, and left club foot. Additionally, she had teething delay and divergent strabismus. Further clinical investigations showed right-to-left atrial shunting, and enlarged right heart. Routine cytogenetic analysis revealed a derivative 15 chromosome with an abnormally short long (q) arm. Subsequent array analysis disclosed a terminal 9.15 Mb deletion detected in band 15q26.1q26.3. Five candidate genes causing the phenotype were within the deleted region, i.e. IGF1R, NR2F2, MEF2A, MCTP2, and CHD2. Conclusion 15q26 monosomy should be considered when growth retardation is associated with ear anomaly, clinodactyly and/or abnormal toe, heart defect mainly atrioventricular septal defects (AVSDs) and/or aortic arch anomaly (AAA).
Autoimmune encephalitis with antibodies against Leucinie-rich Glioma Inactivated 1 and γ-aminobutyric acid-beta-receptor: case report and literature review
Authors: Xie Yi , Wen Jia , Zhao Zhihua , Liu Hongbo , Xie Nanchang 
Published: June 2020

Abstract
A 60-year-old man presented with slow response and psychosis. Apart from hyponatremia, serum test also showed positive anti-Leucinie-rich Glioma Inactivated 1 (anti-LGI1) and anti-γ-aminobutyric acid-beta-receptor (anti-GABABR), and electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid treatment. Here we report the first autoimmune encephalitis(AE) characterized by positive anti-LGI1 and anti-GABABR, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.
The Optimal Duration of Anti-Tuberculous Therapy Before Pericardiectomy in Constrictive Tuberculous Pericarditis
Authors: Fang Likui , Yu Guocan , Zhong Fangming , Chen Gang , Ye Bo 
Published: June 2020

Abstract
Background: It is unclear about the duration of anti-tuberculous therapy before pericardiectomy (DATT) in the patients with constrictive tuberculous pericarditis. This study aims to explore the optimal DATT and its impacts in these patients.Methods: We retrospectively enrolled 93 patients with constrictive tuberculous pericarditis undergoing pericardiectomy and divided them into two groups according to the optimal cutoff value of DATT which was determined by the receiver operating characteristic (ROC) curve and Youden Index. Postoperative and survival outcomes were compared between the two groups.Results: The optimal cutoff value of DATT was 1.05 (months). The enrolled patients were divided into the DATT≤1.05 group and the DATT>1.05 group, with 24 (25.8%) and 69 (74.2%) cases, respectively. Comparing with the DATT≤1.05 group, the DATT>1.05 group had shorter postoperative ICU stay (P=0.023), duration of chest drainage (P=0.002), postoperative hospital stay (P=0.001) and lower incidence of postoperative complications (P<0.001). There was no statistical difference between the two groups in recurrence and survival outcomes.Conclusions: It would be of great benefit to enhanced recovery after pericardiectomy in the patients with constrictive tuberculous pericarditis if DATT lasted for at least one month.
Higher Number of Steps and Breaks During Sedentary Behaviour are Associated with Better Lipid Profiles
Authors: Aho Sonja , Vuoristo Meri-Sisko , Raitanen Jani , Mansikkamäki Kirsi , Alanko Johanna , Vähä-Ypyä Henri , Luoto Riitta , Kellokumpu-Lehtinen Pirkko-Liisa , Vasankari Tommi 
Published: June 2020

Abstract
Background: Physical activity (PA) is known to be associated with lipid profiles and the risk of both cardiovascular diseases and cancer. The aim of this study was to evaluate the association of objectively measured PA, sedentary behaviour (SB), amount of breaks during SB and number of daily steps with serum lipids in a healthy, Finnish, middle-aged, female population.Methods: The participants (571) were recruited at mammography screening, target group was women aged 50-60 years. A measurement of PA was done with accelerometer, blood lipid profile was assessed, and questionnaires of participants characteristics were sent to participants.Results: The participants with the highest number of daily breaks during SB (≥ 41) had the highest mean concentration of HDL-cholesterol (high density lipoprotein cholesterol, HDL-c) (1.9 mmol/l, standard deviation (SD) 0.4) and the lowest mean concentration of triglycerides (1.0 mmol/l, SD 0.5). HDL-c level was 0.16 mmol/l higher (p < 0.001) in the group with 28-40.9 breaks/day and 0.25 mmol/l higher (p < 0.001) among participants with ≥ 41 breaks/day than in the group with the fewest breaks during SB (< 28).Those with the most daily steps (≥ 9100) had the highest mean HDL-c level (1.9 mmol/l). HDL-c level was 0.16 mmol/l higher (p < 0.001) among the participants with 5600-9099 steps/day and 0.26 mmol/l higher (p < 0.001) among participants with ≥ 9100 steps/day than those with the fewest steps (< 5600). The number of daily steps was inversely associated with the triglyceride concentration.From wake-time, participants spent 60% in SB, 18% standing, 14% in light PA, and 9% in moderate-to-vigorous PA (MVPA). PA was associated with serum total cholesterol (TC), HDL-c and triglyceride levels. The mean HDL-c level was the highest in the lowest quartile of SB and in the highest quartile of MVPA.Conclusions: This is the first study showing a high number of objectively measured breaks during SB is associated with a favourable effect on the level of serum lipids, which may later translate into cardiovascular health.Trial registration: This study was registered and approved by the Regional Ethics Committee of Tampere University Hospital in Finland (approval code R15137).
Rising Government Expenditures and Standard of Living in Nigeria: An Ardl Bound Test Approach
Authors: Bowale Kayode Ebenezer , Ezinwa Azuh Dominic , Ilesanmi Olagoke Alfred 
Published: June 2020

Abstract
This study investigated the nexus between standard of living proxy by per capital income (PCI) and the rising four components of capital and recurrent expenditure namely: Administration (ADM), Economic Services (ECS), Social and Community Services (SCS), and Transfer Payments (TRP). The study used data from the Central Bank of Nigeria Statistical Bulletin, 2018 and World Development Indicator, 2018 for the period 1981–2018, using Autoregressive Distributed Lagged (ARDL) Bound Test Approach. The study found that rising government expenditures on these four components of both capital and recurrent spending were negatively and insignificantly related to PCI, those that were positively related were also insignificant, indicating low standard of living of Nigerians during the period of study. We concluded that government expenditure did not improve the standard of living of Nigerians significantly. The study recommended that political officers should always ensure integrity and accountability in handling public funds.JEL CLASSIFICATION: F31, C01, C13, C32, C51