bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Asthma Network Phase I study in Mexico: prevalence of asthma symptoms, risk factors and altitude associations—a cross-sectional study
Authors: Del-Río-Navarro Blanca Estela , Berber Arturo , Reyes-Noriega Nayely , Navarrete-Rodríguez Elsy Maureen , García-Almaraz Roberto , Ellwood Philippa , Garcia-Marcos Luis , Saucedo-Ramírez Omar Josué , Mérida-Palacio Valente Juan , Ramos-García Beatriz Del Carmen , Escalante-Domínguez Alberto José , Linares-Zapién Francisco Javier , Moreno-Gardea Héctor Leonardo , Ochoa-López Georgina , Hernández-Mondragón Luis Octavio , Lozano-Sáenz José Santos , Sacre-Hazouri José Antonio , Juan-Pineda Ángeles , Sánchez-Coronel Ma Guadalupe , Rodríguez-Pérez Noel , Ambriz-Moreno María de Jesús 
Published: December 2020

BackgroundGlobal Asthma Network (GAN) was established in 2012 as a development to the International Study of Asthma and Allergies in Childhood to improve asthma care globally.ObjectiveTo survey asthma, allergic rhinitis and atopic dermatitis in primary and secondary school children and to investigate and evaluate its prevalence, severity, management and risk factors in Mexico.MethodsGAN Phase I is a cross-sectional, multicentre survey carried out in 15 centres corresponding to 14 Mexican cities throughout 2016–2019 using the validated Spanish language version of the GAN Phase I questionnaires. The questionnaires were completed by parents of 6–7-year-old primary school pupils (school children) and by 13–14-year-old adolescents.ResultsA total of 35 780 school children and 41 399 adolescents participated. Wheezing ever prevalence was 26.2% (95% CI 25.8% to 26.7%) in school children and 23.9% (95% CI 23.4% to 24.3%) in adolescents. The corresponding frequencies for current wheeze were 10.2% (95% CI 9.9% to 10.5%) and 11.6% (95% CI 11.2% to 11.9%). In school children, the risk factors for current wheeze were rhinitis (OR 4.484; 95% CI 3.915% to 5.134%) and rash symptoms (OR 1.735; 95% CI 1.461% to 2.059%). For adolescents, rhinitis symptoms (OR 3.492; 95% CI 3.188% to 3.825%) and allergic rhinitis diagnosis (OR 2.144; 95% CI 1.787% to 2.572%) were the most significant. For both groups, there was a negative relation with centres’ sea level altitude higher than 1500 m above mean sea level (p<0.005).ConclusionsThe most important risk factors for asthma symptoms in both age groups were the presence of rhinitis and rash symptoms or diagnosis. On the other hand, sea level altitude higher than 1500 metres was a protective factor.
‘Advance care planning, general practitioners and patients: a phase II cluster-randomised controlled trial in chronic life-limiting illness’
Authors: Dierickx Sigrid , Pardon Koen , Pype Peter , Stevens Julie , Vander Stichele Robert , Deliens Luc , De Vleminck Aline 
Published: December 2020

ObjectivesAlthough general practice is an ideal setting for ensuring timely initiation of advance care planning (ACP) in people with chronic life-limiting illness, evidence on the effectiveness of ACP in general practice and how it can be implemented is lacking. This study aims to evaluate feasibility and acceptability of study procedures and intervention components of an intervention to facilitate the initiation of ACP in general practice for people with chronic life-limiting illness.MethodsPilot cluster-randomised controlled trial testing a complex ACP intervention in general practice versus usual care (ClinicalTrials.gov:NCT02775032). We used a mixed methods approach using detailed documentation of the recruitment process, questionnaires and semi-structured interviews.ResultsA total of 25 general practitioners (GPs) and 38 patients were enrolled in the study. The intervention was acceptable to GPs and patients, with GPs valuing the interactive training and patients finding ACP conversations useful. However, we found a number of challenges regarding feasibility of recruitment procedures, such GP as recruitment proceeding more slowly than anticipated as well as difficulty applying the inclusion criteria for patients. Some GPs found initiating ACP conversations difficult. The content of the patient booklet was determined to potentially be too complex for patients with a lower health literacy.ConclusionAlthough the intervention was well-accepted by GPs and patients, we identified critical points for improvement with regard to the study procedures as well as potential improvements of the intervention components. When these points are addressed, the intervention can proceed to a large-scale, phase III trial to test its effectiveness.
Three-dimensional non-relativistic extended supergravity with cosmological constant
Authors: Concha Patrick , Ravera Lucrezia , Rodríguez Evelyn 
Published: December 2020

AbstractIn this paper, we present two novel non-relativistic superalgebras which correspond to supersymmetric extensions of the enlarged extended Bargmann algebra. The three-dimensional non-relativistic Chern–Simons supergravity actions invariant under the aforementioned superalgebras are constructed. The new non-relativistic superalgebras allow to accommodate a cosmological constant in a non-relativistic supergravity theory. Interestingly, we show that one of the non-relativistic supergravity theories presented here leads to the recently introduced Maxwellian exotic Bargmann supergravity when the flat limit $$\ell \rightarrow \infty $$

ℓ
→
∞

is considered. Besides, we show that both descriptions can be written in terms of a supersymmetric extension of the Nappi–Witten algebra or the extended Newton–Hooke superalgebra.
The Late Cenozoic volcanic groups in the South Daxing'anling, NE China: geology, geochemistry, and chronology
Authors: Li Ni , Zhao Yong-Wei , Gong Li-Wen , Wang Jia-Long 
Published: December 2020

Abstract
During the late Cenozoic, the extensional tectonic setting in northeastern China caused large-scale block uplifts and depressions, and thus a large amount of magma erupted along structural fractures in the eastern Inner Mongolia, NE China. The Abaga, Beilike, Dalinor and Wulanhada (ABDW) volcanic rocks along the Daxing'anling–Taihangshan Gravity Lineament in the southern section of the Daxing'anling are characterized by their extensive distribution, numerous volcanic cones and various eruption types. Each volcanic group has distinctive volcanic landforms and geochemical characteristics. The geochronological data have revealed that the volcanism spanned Miocene to late Pleistocene. The ABDW volcanic rocks contain primary alkaline basalts and subordinate tholeiites. The trace element curve pattern is similar to that of ocean island basalt, but completely different from that of mid ocean ridge basalt, while the light rare earth elements are more enriched than the heavy rare earth elements. The geochemical features of the volcanic rocks and the entrained mantle xenoliths reveal the broad heterogeneities of the lithospheric mantle and varieties of the volcanic rock evolution in the south Daxing'anling. The Cenozoic volcanism in eastern Inner Mongolia, and even within the east Asian plate, is attributed to the westward subduction and rolling backward of the Pacific slab, as well as the trench retreat.
Hosea 6:5 and the Decalogue
Authors: Leuchter Mark 
Published: December 2020

Abstract
The relationship between the Decalogue (in Exod 20) and the oracles of Hosea has been the source of much speculation with regard to directions of influence, common sources, shared motifs, and the historical settings for their respective compositions. While some scholars have speculated that the Decalogue informed Hosea’s oracles, a closer look at Hos 6:5 suggests that both textual traditions emerged from a response to the growing influence of Assyrian imperial inscriptions and political propaganda in the late 8th century BCE. Hosea 6:5 constructs a theology where YHWH also communicates through written inscriptions – reinforced by the voices of his prophetic agents – in protest of Assyrian cultural and political hegemony. This and other elements in the book of Hosea carry implications for the origins of the Decalogue, the role of Moses as its advocate/mediator, and the relationship between law and prophecy in late monarchic Israel.
Coronavirus, Population and the Economy: A Long-Term Perspective
Authors: Sengupta Sarbajit 
Published: December 2020

This article attempts to construct an extremely rudimentary framework to argue that the long-term losses from the pandemic shock are likely to far exceed the short-term one. In the simple structure presented here, output depends on labour force, efficiency that is determined by past nutrition levels and capital accumulated from the past. The immediate effect of the pandemic is to lower the effective labour size, principally due to lockdowns to prevent or delay the spread of the pandemic. The other two factors cannot be affected. However, the decline in present output is likely to lower both the efficiency of labour and the future capital along with the labour supply in the future, thereby causing a greater impact on future output. JEL Codes: I15, J11, J21
Single mothers coping with food insecurity in a Nairobi slum
Authors: Madhavan Sangeetha , Clark Shelley , Schmidt Sara 
Published: December 2020

With high urbanisation rates, cities in sub-Saharan Africa are contending with food insecurity. Urban studies scholars have approached the issue mainly from the perspective of food deserts. We adapt Sen’s ‘resource bundles’ and Watts and Bohles’s ‘space of vulnerability’ concepts to examine food insecurity as a function of both tangible and intangible resources. Moreover, we also interrogate the role of kin in strengthening safety nets for the urban poor. Drawing on a data set of 462 single mothers in a slum in Nairobi, Kenya, we find that (1) bundles comes in four types; (2) bundles with high levels of all resources buffer against food insecurity as do (3) bundles weighted with high levels of wealth and social standing; and (4) kin enhance the protective effect of bundles only for two types. These findings should direct urban poverty researchers to consider the compounding effect of resources in the reproduction of poverty and social inequality and encourage policy makers to focus on both vulnerability and resilience in designing interventions to ensure food security.
Evaluation of chemotherapy-related peripheral neuropathy in lung cancer treatment
Authors: Dasdemir Ilkhan Gulay , Celikhisar Hakan 
Published: December 2020

Objective: Chemotherapy-related peripheral neuropathies are observed frequently in lung cancer treatment in clinical practice. The present study aimed to evaluate the electrophysiologic findings and clinical symptoms in patients treated for lung cancer with different chemotherapy regimens who had the findings of peripheral neuropathy. Methods: Patients who had electromyography (EMG) examinations with the prediagnosis of peripheral neuropathy at two different centers between January 2011 and December 2019 were included. The demographic data, neurologic examination findings, symptoms, EMG findings, and chemotherapeutic agents used in the treatment were evaluated retrospectively. Results: A total of 742 patients were included in the study, with 630 (84.90%) male and 112 (15.10%) female patients. Of the patients included in the study, 406 (54.71%) had positive sensorial symptoms, 494 (66.57%) had negative sensorial symptoms, 162 (21.83%) had motor symptoms, and 254 (34.23%) had pain symptoms. The patients were classified into two groups on the basis of the presence of polyneuropathy detected via EMG as group I (n = 500, 67.38%) including the patients with polyneuropathy and group II (n = 242, 32.61%) including the patients without polyneuropathy. Negative sensorial symptoms and motor symptoms in group I along with dysesthesia and paresthesia symptoms in group II were observed at ratios that were higher at a statistically significant level ( p = 0.001, p = 0.001, p = 0.001, p = 0.001). Conclusion: Sensorial symptoms are observed most frequently in chemotherapy-related peripheral neuropathies in lung cancer treatment and motor symptoms may also increase according to the chemotherapy regimen.
Histological evaluation of acetabular bone quality during revision hip arthroplasty
Authors: Bistolfi Alessandro , Linari Alessandra , Aprato Alessandro , Fusini Federico , Cravero Ester , Papotti Mauro , Ferracini Riccardo , Massè Alessandro 
Published: December 2020

Purpose: Aim of this study was to evaluate acetabular bone vitality during revision hip arthroplasty and to compare the bone quality between revision and primary acetabular arthroplasty. Methods: During primary and revision total hip arthroplasty surgeries, biopsies were taken from the acetabulum after reaming. The samples (osteochondral cylinders of approximately ⩽1 cm long and 3 mm thickness), after removing the mineral component, were cut longitudinally with a thickness section of 5 µm and colored with hematoxylin-eosin dichromic dye and then evaluated histologically by optical microscopy with 40× magnification. Preoperative radiographs were evaluated. Results: According to inclusion and exclusion criteria, 14 patients formed the revision group patients (mean age: 67.9 years, average time before revision 8.8 years, SD ± 7.06) and 5 patients formed the control primary group (mean age: 61.4 years). The bone quality of the revision group was generally poorer than the primary group, while similar vitality and bone quality has been found between septic and aseptic group. Variables such as age, gender and BMI did not significantly contribute to define bone quality classes. Conclusions: The study confirms the differences in quality and bone vitality between cases and controls and the necessity to find strategies to improve the osteointegrative processes in revision arthroplasties.
Impact of general anesthesia on posterior circulation large vessel occlusions after endovascular thrombectomy
Authors: Terceño Mikel , Silva Yolanda , Bashir Saima , Vera-Monge Víctor A , Cardona Pere , Molina Carlos , Chamorro Ángel , de la Ossa Natalia P , Hernández-Pérez María , Werner Mariano , Camps-Renom Pol , Rodríguez-Campello Ana , Cánovas David , Purroy Francisco , Serena Joaquín ,   on behalf of the Catalan Stroke Code and Reperfusion Consortium (Cat-SCR)
Published: December 2020

Background The impact of general anesthesia on functional outcome in patients with large vessel occlusion remains unclear. Most studies have focused on anterior circulation large vessel occlusion; however, little is known about the effect of general anesthesia in patients with posterior circulation—large vessel occlusion. Methods We performed a retrospective analysis from the prospective CICAT registry. All patients with posterior circulation—large vessel occlusion—and undergoing endovascular therapy between January 2016 and January 2020 were included. Demographics, baseline characteristics, procedural data, and anesthesia modality (general anesthesia or conscious sedation) were evaluated. The primary outcome was the proportion of patients with good clinical outcome (modified Rankin Scale score of 0–2) at three months. Results 298 patients underwent endovascular treatment with posterior circulation—large vessel occlusion—were included. Age, diabetes mellitus, renal insufficiency, baseline National Institutes of Health Stroke Scale score, puncture to recanalization length, ≥3 device passes, absent of successful recanalization (defined as treatment in cerebral ischemia of 3), and general anesthesia were statistically associated with poor outcome (mRS: 3-6). In the multivariable regression, general anesthesia and ≥3 device passes were independently associated with poor outcome (aOR: 3.11, (95% CI: 1.34–7.2); P = 0.01 and 3.77, (95% CI: 1.29–11.01); P = 0.02, respectively). Patients treated with general anesthesia were less likely to have a good outcome at three months compared to conscious sedation (19.7% vs. 45.1%, P < 0.001). Conclusions In our study population, general anesthesia use is associated with poor clinical outcome in patients with posterior circulation—large vessel occlusion—treated endovascularly.
White matter: A good reference for the signal intensity evaluation in magnetic resonance imaging for the diagnosis of uveal melanoma
Authors: Hirunpat Pornrujee , Sanghan Nuttha , Hirunpat Siriporn 
Published: December 2020

Background Comparing the signal intensity (SI) of an ocular mass to that of the vitreous body has been suggested. Most ocular lesions show a hyper-intense signal compared to the vitreous body on T1-weighted (T1w) images, and malignant melanomas have been almost always determined as ‘cannot be excluded’ in reports. Purpose This study aimed to determine the accuracy of magnetic resonance imaging (MRI) in the diagnosis of uveal melanoma by using normal white matter as reference tissue for SI evaluation on T1w images and vitreous body on T2w compared to the conventional method using the vitreous body as a reference on both T1w and T2w images. Methods The MRIs of 43 patients (between August 2006 and July 2018) sent to rule out uveal melanoma were blindly reviewed by two radiologists. By using white matter as a reference for SI evaluation on T1w images and vitreous body as a reference on T2w images, uveal melanomas were suggested by hyper-intense signal on T1w and hypo-intense signal on T2w with homogeneous enhancement. The accuracy of diagnosis of uveal melanoma using white matter as a reference on T1w was compared to the conventional method using the vitreous body as a reference on both T1w and T2w images. Results The diagnosis of uveal melanoma using white matter as a reference gave a sensitivity of 92.31% (95% confidence interval (CI) 63.97–99.81) and specificity of 100.0% (95% CI 88.43–100.0). By using the vitreous body as a reference, sensitivity as high as 100.0% (95% CI 100.0–100.0) was obtained, but specificity was low at 53.33% (95% CI 34.33–71.66). Conclusions White matter is a good reference for the diagnosis of uveal melanoma, with high sensitivity and much higher specificity than conventional methods using the vitreous body as a reference.
The impact of adenotonsillectomy on monosymptomatic primary nocturnal enuresis in children with obstructive sleep apnea syndrome
Authors: Ghanem Mazen A , Swaid Ali I , Adawi Essa A , Ghanem Rim M , Ghanem Ahmed M , Aqeel Mohammed A , Safan Manal A 
Published: December 2020

Objectives: To analyze the outcome of monosymptomatic primary nocturnal enuresis (MPNE) after adenotonsillectomy in children with obstructive sleep apnea syndrome (OSAS). Methods: The study included 74 MPNE children with OSAS qualified for an adenotonsillectomy procedure. MPNE was assessed prior to surgical procedure as well as 3 and 6 months after surgery. In addition to polysomnographic parameters, serum antidiuretic hormone (ADH) and brain natriuretic peptide (BNP) levels were measured preoperatively and 3 months postoperatively. Results: The mean age was 9.8 years and the mean number of nocturnal wetting weekly was 4.1. Thirty-eight percent of patients had family history of MPNE. All the patients underwent a successful adenotonsillectomy. Nocturnal enuresis was still reported in 18% of children 6 months after adenotonsillectomy. An increased risk of MPNE was significantly demonstrated in children with high obstructive apnea-hypopnea index (O-AHI), high oxygen desaturation index (ODI), high frequent nocturnal enuresis and family history. After surgery, ADH levels were significantly lower, whereas BNP levels were significantly higher in non-resolution children. Univariate analysis showed that higher O-AHI, higher ODI, severe enuresis, low serum ADH and higher serum BNP levels were indicative of persistent nocturnal enuresis. Multivariate analysis showed that higher ODI and higher BNP levels are independent prognostic markers for MPNE. Conclusions: Adenotonsillectomy in MPNE children with OSAS is an effective treatment for resolution of MPNE. Also, higher ODI caused by apnea and elevated serum BNP levels are the most important factors affecting the outcome of MPNE patients. Level of evidence: Not applicable for this multicentre audit.
LabPipe: an extensible bioinformatics toolkit to manage experimental data and metadata
Authors: Zhao Bo , Bryant Luke , Cordell Rebecca , Wilde Michael , Salman Dahlia , Ruszkiewicz Dorota , Ibrahim Wadah , Singapuri Amisha , Coats Tim , Gaillard Erol , Beardsmore Caroline , Suzuki Toru , Ng Leong , Greening Neil , Thomas Paul , Monks Paul , Brightling Christopher , Siddiqui Salman , Free Robert C. 
Published: December 2020

Abstract
Background
Data handling in clinical bioinformatics is often inadequate. No freely available tools provide straightforward approaches for consistent, flexible metadata collection and linkage of related experimental data generated locally by vendor software.

Results
To address this problem, we created LabPipe, a flexible toolkit which is driven through a local client that runs alongside vendor software and connects to a light-weight server. The toolkit allows re-usable configurations to be defined for experiment metadata and local data collection, and handles metadata entry and linkage of data. LabPipe was piloted in a multi-site clinical breathomics study.

Conclusions
LabPipe provided a consistent, controlled approach for handling metadata and experimental data collection, collation and linkage in the exemplar study and was flexible enough to deal effectively with different data handling challenges.
Characteristic patterns of emergency ambulance assignments for older adults compared with adults requiring emergency care at home in Sweden: a total population study
Authors: Hjalmarsson Anna , Holmberg Mats , Asp Margareta , Östlund Gunnel , Nilsson Kent W. , Kerstis Birgitta 
Published: December 2020

Abstract
Background
Since the vast majority of older adults in Sweden live in their private homes throughout life, the emergency medical services need to adapt accordingly. Hence, we aimed to describe characteristic patterns of dyadic staffed emergency ambulance assignments for older adults aged > 70 years compared with adults aged 18–69 years requiring emergency care at home in Sweden.

Methods
A descriptive retrospective study was performed using anonymized registry data from the emergency medical services in a region of Sweden during 2017–2018. One-sample χ2 test, one-way analysis of variance, and binary logistic regression models were used for investigating group differences. Variables for analysis were age, gender, clinical assessments, on-scene time, priority levels, result of response, and temporal patterns.

Results
Of all included emergency ambulance assignments (n = 28,533), 59.9% involved older adults, of which 53.8% were women. The probability for older adults to receive the highest priority was decreased for both dispatch (p < 0.001, odds ratio [OR] 0.63, 95% confidence interval [CI] 0.59–0.66), and transport priorities (p < 0.001, OR 0.74, 95% CI 0.68–0.80). Older adults were more likely to receive dispatch priority levels 2 (p < 0.001, OR 1.48, 95% CI 1.40–1.56), and 3 (p < 0.001, OR 1.73, 95% CI 1.46–2.06). The older adults were similarly more likely to receive transport priority level 3 (p < 0.001, OR 1.40, 95% CI 1.28–1.52) compared with adults. Age had a small but additive effect in relation to on-scene time (p < 0.001, R2 = 0.01, F = 53.82). Distinguishing initial clinical assessments for older adults were circulatory, respiratory, trauma, infection, and nonspecific assessments. Emergency ambulance assignments for older adults were more frequently occurring on Mondays (p < 0.001, χ2 = 232.56), and in the 08:00–11:59 interval (p < 0.001, χ2 = 1224.08).

Conclusion
The issues of the lower priority level preponderance, and the decreased probability for receiving the highest priority warrant further attention in future research and clinical practice.