bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction to the Special Issue ‐ The Brave New World: How shopping and consumption is evolving with technology
Authors: Goode Miranda , Main Kelley 
Published: December 2019

AbstractThis special issue of the Canadian Journal of Administrative Sciences features four articles using various methodologies to explore the interplay of technology and consumption. Through an exploration of identity expression in virtual reality to the consumption of fashion media and culture to inspiring the use of wearables, we learn that although new technologies may change traditional consumption patterns, fundamental human needs persist. From this special issue, it is evident the so‐called brave new world will require companies, and marketers especially, to not lose sight of the human when using and experimenting with technologies to streamline and enhance consumption and marketplace experiences.
Facile Synthesis of α‐Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source
Authors: Luo Zhibin , Meng Yunge , Gong Xinchi , Wu Jie , Zhang Yulan , Ye Long‐Wu , Zhu Chunyin 
Published: December 2019

Summary of main observation and conclusionAn operationally simple and safe synthesis of α‐haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron‐catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible‐light. This strategy avoids the risks associated with handling halo‐contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.
Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study
Authors: Mueller Sabine , Kline Cassie N. , Buerki Robin A. , Chen Yan , Yasui Yutaka , Howell Rebecca , Oeffinger Kevin C. , Leisenring Wendy M. , Robison Leslie L. , Armstrong Gregory T. , Fullerton Heather J. , Krull Kevin R. 
Published: December 2019

BackgroundPoor socioeconomic and health‐related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke and stroke recurrence on mortality, psychological HRQOL, and socioeconomic outcomes within the Childhood Cancer Survivor Study (CCSS).MethodsThe CCSS is a retrospective cohort study with longitudinal follow‐up concerning survivors of pediatric cancer who were diagnosed between 1970 and 1986. Mortality rates per 100 person‐years were calculated across 3 periods: 1) prior to stroke; 2) after first stroke and before recurrent stroke; and 3) after recurrent stroke. Socioeconomic outcomes, the standardized Brief Symptoms Inventory–18, the Medical Outcomes Study 36‐Item Short Form Health Survey, and the CCSS–Neurocognitive Questionnaire also were assessed.ResultsAmong 14,358 participants (median age, 39.7 years), 224 had a stroke after their cancer diagnosis (single stroke in 161 patients and recurrent stroke in 63 patients). Based on 2636 deaths, all‐cause late mortality rates were 0.70 (95% CI, 0.68‐0.73) prior to stroke, 1.03 (95% CI, 0.73‐1.46) after the first stroke, and 2.42 (95% CI, 1.48‐3.94) after the recurrent stroke. Among 7304 survivors, those with stroke were more likely to live with a caregiver (single stroke odds ratio [OR], 2.3 [95% CI, 1.4‐3.8]; and recurrent stroke OR, 5.3 [95% CI, 1.7‐16.8]) compared with stroke‐free survivors. Stroke negatively impacted task efficiency (single stroke OR, 2.4 [95% CI, 1.4‐4.1] and recurrent stroke OR, 3.3 [95% CI, 1.1‐10.3]) and memory (single stroke OR, 2.1 [95% CI, 1.2‐3.7]; and recurrent stroke OR, 3.5 [95% CI, 1.1‐10.5]).ConclusionsStroke and stroke recurrence are associated with increased mortality and negatively impact HRQOL measures in survivors of pediatric cancer.
Trajectories of returning to work and its impact on survival in survivors with oral cancer: A 5‐year follow‐up study
Authors: Chen Yuan‐Yuei , Wang Chung‐Ching , Wu Wei‐Te , Lai Ching‐Huang , Ho Ching‐Liang , Hsu Ya‐Yuan , Chen Wei‐Liang 
Published: December 2019

BackgroundA return to work (RTW) is a challenge for survivors of oral cancer. Further light could be shed on the RTW of patients with oral cancer, which remains largely uninvestigated. The objective of this study was to investigate the trajectories of RTW and their impact on survival in workers with oral cancer.MethodsIn total, 12,222 workers who were newly diagnosed with oral cancer were identified during the period from 2004 to 2015 and were included in this cohort study. The associations between independent variables and RTW were analyzed using Cox proportional hazard models.ResultsOverall, 8793 workers returned to work in the first years after a diagnosis of oral cancer. Chemotherapy (hazard ratio [HR], 0.88; 95% CI, 0.78‐0.99) and radiation therapy (HR, 0.83; 95% CI, 0.75‐0.92) were inversely associated with RTW. Patients who had received surgical treatment (HR, 1.24; 95% CI, 1.01‐1.53) were more likely to RTW. Employees with stage I (HR, 1.66; 95% CI, 1.47‐1.87), stage II (HR, 1.52; 95% CI, 1.35‐1.72), and stage III (HR, 1.32; 95% CI, 1.16‐1.51) disease were associated with an increased likelihood of RTW in the fifth year after diagnosis. Kaplan‐Meier survival analysis demonstrated better survival for the RTW group versus the non‐RTW group in patients with stage III and IV oral cancer (P < .001). The fully adjusted HR indicated that the RTW group had significantly better outcomes than the non‐RTW group in all‐cause mortality (P < .001; HR, 0.36; 95% CI, 0.33‐0.39).ConclusionsSociodemographic and medical factors affect the RTW of cancer survivors. RTW may have a beneficial effect on survival of patients with oral cancer.
Numerical simulation of the blood oxygenation level–dependent functional magnetic resonance signal using finite element method
Authors: Mangini Fabio , DiNuzzo Mauro , Maugeri Laura , Moraschi Marta , Mascali Daniele , Cedola Alessia , Frezza Fabrizio , Giove Federico , Fratini Michela 
Published: December 2019

AbstractSince the introduction of functional magnetic resonance imaging (fMRI), several computational approaches have been developed to examine the effect of the morphology and arrangement of blood vessels on the blood oxygenation‐level dependent (BOLD) signal in the brain. In the present work, we implemented the original Ogawa's model using a numerical simulation based on the finite element method (FEM) instead of the analytical models. In literature, there are different works using analytical methods to analyse the transverse relaxation rate (
), which BOLD signal is related to, modelling the vascular system with simple and canonical geometries such as an infinite cylinder model (ICM) or a set of cylinders. We applied the numerical simulation to the extravascular BOLD signal as a function of angular vessel distribution (perpendicular vs parallel to the static magnetic field) relevant for anatomical districts characterized by geometrical symmetries, such as spinal cord. Numerical simulations confirmed analytical results for the canonical ICM. Moreover, the perturbation to the magnetic field induced by blood deoxyhaemoglobin, as quantified assuming Brownian diffusion of water molecules around the vessel, revealed that vessels contribute the most to the variation of the
when they are preferentially perpendicular to the external magnetic field, regardless of their size. Our results indicate that the numerical simulation method is sensitive to the effects of different vascular geometry. This work highlights the opportunity to extend
simulations to realistic models of vasculature based on high‐resolution anatomical images.
Telehealth and telemedicine applications for the diabetic foot: A systematic review
Authors: Hazenberg Constantijn E. V. B. , aan de Stegge Wouter B. , Van Baal Sjef G. , Moll Frans L. , Bus Sicco A. 
Published: December 2019

SummaryThe aim of this systematic review is to assess the peer‐reviewed literature on the psychometric properties, feasibility, effectiveness, costs, and current limitations of using telehealth and telemedicine approaches for prevention and management of diabetic foot disease. MEDLINE/PubMed was searched for peer‐reviewed studies on telehealth and telemedicine approaches for assessing, monitoring, preventing, or treating diabetic foot disease. Four modalities were formulated: dermal thermography, hyperspectral imaging, digital photographic imaging, and audio/video/online communication. Outcome measures were: validity, reliability, feasibility, effectiveness, and costs. Sixty‐one studies were eligible for analysis. Three randomized controlled trials showed that handheld infrared dermal thermography as home‐monitoring tool is effective in reducing ulcer recurrence risk, while one small trial showed no effect. Hyperspectral imaging has been tested in clinical settings to assess and monitor foot disease and conflicting results on its diagnostic use show that this method is still in an experimental stage. Digital photography is used to assess and monitor foot ulcers and pre‐ulcerative lesions and was found to be a valid, reliable, and feasible method for telehealth purposes. Audio/video/online communication is mainly used for foot ulcer monitoring. Two randomized controlled trials show similar healing efficacy compared with regular outpatient clinic visits, but no benefit in costs. In conclusion, several technologies with good psychometric properties are available that may be of benefit in helping to assess, monitor, prevent, or treat diabetic foot disease, but in most cases, feasibility, effectiveness, and cost savings still need to be demonstrated to become accepted and used modalities in diabetic foot care.
Invasive Phragmites australis management outcomes and native plant recovery are context dependent
Authors: Rohal Christine B. , Cranney Chad , Hazelton Eric L. G. , Kettenring Karin M. 
Published: December 2019

AbstractThe outcomes of invasive plant removal efforts are influenced by management decisions, but are also contingent on the uncontrolled spatial and temporal context of management areas. Phragmites australis is an aggressive invader that is intensively managed in wetlands across North America. Treatment options have been understudied, and the ecological contingencies of management outcomes are poorly understood. We implemented a 5‐year, multi‐site experiment to evaluate six Phragmites management treatments that varied timing (summer or fall) and types of herbicide (glyphosate or imazapyr) along with mowing, plus a nonherbicide solarization treatment. We evaluated treatments for their influence on Phragmites and native plant cover and Phragmites inflorescence production. We assessed plant community trajectories and outcomes in the context of environmental factors. The summer mow, fall glyphosate spray treatment resulted in low Phragmites cover, high inflorescence reduction, and provided the best conditions for native plant recruitment. However, returning plant communities did not resemble reference sites, which were dominated by ecologically important perennial graminoids. Native plant recovery following initial Phragmites treatments was likely limited by the dense litter that resulted from mowing. After 5 years, Phragmites mortality and native plant recovery were highly variable across sites as driven by hydrology. Plots with higher soil moisture had greater reduction in Phragmites cover and more robust recruitment of natives compared with low moisture plots. This moisture effect may limit management options in semiarid regions vulnerable to water scarcity. We demonstrate the importance of replicating invasive species management experiments across sites so the contingencies of successes and failures can be better understood.
Selenium and outcome in heart failure
Authors: Bomer Nils , Grote Beverborg Niels , Hoes Martijn F. , Streng Koen W. , Vermeer Mathilde , Dokter Martin M. , IJmker Jan , Anker Stefan D. , Cleland John G.F. , Hillege Hans L. , Lang Chim C. , Ng Leong L. , Samani Nilesh J. , Tromp Jasper , van Veldhuisen Dirk J. , Touw Daan J. , Voors Adriaan A. , van der Meer Peter 
Published: December 2019

AbstractAimsSevere deficiency of the essential trace element selenium can cause myocardial dysfunction although the mechanism at cellular level is uncertain. Whether, in clinical practice, moderate selenium deficiency is associated with worse symptoms and outcome in patients with heart failure is unknown.Methods and resultsBIOSTAT‐CHF is a multinational, prospective, observational cohort study that enrolled patients with worsening heart failure. Serum concentrations of selenium were measured by inductively coupled plasma mass spectrometry. Primary endpoint was a composite of all‐cause mortality and hospitalization for heart failure; secondary endpoint was all‐cause mortality. To investigate potential mechanisms by which selenium deficiency might affect prognosis, human cardiomyocytes were cultured in absence of selenium, and mitochondrial function and oxidative stress were assessed. Serum selenium concentration (deficiency) was <70 μg/L in 485 (20.4%) patients, who were older, more often women, had worse New York Heart Association class, more severe signs and symptoms of heart failure and poorer exercise capacity (6‐min walking test) and quality of life (Kansas City Cardiomyopathy Questionnaire). Selenium deficiency was associated with higher rates of the primary endpoint [hazard ratio (HR) 1.23; 95% confidence interval (CI) 1.06–1.42] and all‐cause mortality (HR 1.52; 95% CI 1.26–1.86). In cultured human cardiomyocytes, selenium deprivation impaired mitochondrial function and oxidative phosphorylation, and increased intracellular reactive oxygen species levels.ConclusionsSelenium deficiency in heart failure patients is independently associated with impaired exercise tolerance and a 50% higher mortality rate, and impaired mitochondrial function in vitro, in human cardiomyocytes. Clinical trials are needed to investigate the effect of selenium supplements in patients with heart failure, especially if they have low plasma concentrations of selenium.
Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells
Authors: Valta Milla , Gazali Ahmad Mahfuz , Viisanen Tyyne , Ihantola Emmi‐Leena , Ekman Ilse , Toppari Jorma , Knip Mikael , Veijola Riitta , Ilonen Jorma , Lempainen Johanna , Kinnunen Tuure 
Published: December 2019

AbstractDysfunction of FOXP3‐positive regulatory T cells (Tregs) likely plays a major role in the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). Whether genetic polymorphisms associated with the risk of autoimmune diseases affect Treg frequency or function is currently unclear. Here, we analysed the effect of T1D‐associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non‐HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243), and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. These were determined by flow cytometry in 65 subjects who had progressed to T1D, 86 islet autoantibody‐positive at‐risk subjects, and 215 islet autoantibody‐negative healthy controls. The PTPN22 rs2476601 risk allele A was associated with an increase in total (p = 6 × 10−6) and naïve (p = 4 × 10−5) CD4+CD25+CD127lowFOXP3+ Treg frequencies. These findings were validated in a separate cohort comprising ten trios of healthy islet autoantibody‐negative children carrying each of the three PTPN22 rs2476601 genotypes AA, AG, and GG (p = 0.005 for total and p = 0.03 for naïve Tregs, respectively). In conclusion, our analysis implicates the autoimmune PTPN22 rs2476601 risk allele A in controlling the frequency of Tregs in human peripheral blood.
Attachments in the workplace: How attachment security in the workplace benefits the organisation
Authors: Luke Michelle A. , Carnelley Katherine B. , Sedikides Constantine 
Published: December 2019

AbstractIn four studies, we tested if workplace secure attachment entails organisational benefits, given that such relationships are associated with increased positive relationship emotions. In Study 1, employees rated the extent to which colleagues, supervisors, and other individuals fulfil the attachment functions. In Study 2, employees listed up to 10 individuals before completing the same rating task as Study 1. In the remaining studies, employees rated their attachment security with their supervisors (Study 3) or colleagues (Study 4), and completed measures of positive relationship emotions with these individuals, proactive behaviour, organisational allure, and organisational deviance. We found that supervisors and colleagues fulfil attachment functions (Studies 1–2), and that workplace attachment security confers organisational allure and proactive behaviour due to its association with positive relationships emotions. However, workplace attachment security directly lowers organisational deviance (Studies 3–4). Thus, supportive and trusting work environments may encourage workplace relationships that could bestow organisational benefits.
Modeling sea‐level processes on the U.S. Atlantic Coast
Authors: Berrett Candace , Christensen William F. , Sain Stephan R. , Sandholtz Nathan , Coats David W. , Tebaldi Claudia , Lopes Hedibert F. 
Published: December 2019

AbstractOne of the major concerns engendered by a warming climate are changing sea levels and their lasting effects on coastal populations, infrastructures, and natural habitats. Sea levels are now monitored by satellites, but long‐term records are only available at discrete locations along the coasts. Sea levels and sea‐level processes must be better understood at the local level to best inform real‐world adaptation decisions. We propose a statistical model that facilitates the characterization of known sea‐level processes, which jointly govern the observed sea level along the United States Atlantic Coast. Our model not only incorporates long‐term sea level rise and seasonal cycles but also accurately accounts for residual spatiotemporal processes. By combining a spatially varying coefficient modeling approach with spatiotemporal factor analysis methods in a Bayesian framework, the method represents the contribution of each of these processes and accounts for corresponding dependencies and uncertainties in a coherent way. Additionally, the model provides a consistent way to estimate these processes and sea level values at unmonitored locations along the coast. We show the outcome of the proposed model using thirty years of sea level data from 38 stations along the Atlantic (east) Coast of the United States. Among other results, our method estimates the rate of sea level rise to range from roughly 1 mm/year in the northern and southern regions of the Atlantic coast to 5.4 mm/year in the middle region.
Predicting extreme surges from sparse data using a copula‐based hierarchical Bayesian spatial model
Authors: Beck N. , Genest C. , Jalbert J. , Mailhot M. 
Published: December 2019

AbstractA hierarchical Bayesian model is proposed to quantify the magnitude of extreme surges on the Atlantic coast of Canada with limited data. Generalized extreme value distributions are fitted to surges derived from water levels measured at 21 buoys along the coast. The parameters of these distributions are linked together through a Gaussian field whose mean and variance are driven by atmospheric sea‐level pressure and the distance between stations, respectively. This allows for information sharing across the original stations and for interpolation anywhere along the coast. The use of a copula at the data level of the hierarchy further accounts for the dependence between locations, allowing for inference beyond a site‐by‐site basis. It is shown how the extreme surges derived from the model can be combined with the tidal process to predict potentially catastrophic water levels.
Manufacturing of nanoliposomal extract from Sargassum boveanum algae and investigating its release behavior and antioxidant activity
Authors: Savaghebi Davood , Barzegar Mohsen , Mozafari Mohammad Reza 
Published: December 2019

AbstractIn this paper, the fabrication of algal extract‐loaded nanoliposomes was optimized based on the central composite response surface design. Different concentrations of phenolic compounds (500, 1,000, and 1,500 ppm) of algal extract and lecithin (0.5, 1.25, and 2% w/w) were applied for preparation of nanoliposomes at process temperatures of 30, 50, and 70°C. Dependent variables were zeta potential, entrapment efficiency, size, and particle size distribution. The particle size of the loaded nanoliposomes ranged from 86.6 to 118.7 nm and zeta potential from −37.3 to −50.7 mV. The optimal conditions were as follows: 0.5% lecithin, 30°C process temperature, and 1,313 ppm of the phenolic compounds extracted from algae. Under these conditions, the experimental entrapment efficiency of the phenolic compounds was 45.5 ± 1.2%. FTIR analysis has verified the encapsulation of algal extract in nanoliposomes. Algal extract phenolic compounds also increased phase transition temperature (Tc) of nanoliposomes (1.6°C to 6.3°C). Moreover, the thermo‐oxidative protection of nanoliposomes for the algal extract has been proved by examining the DSC thermograms. It has been demonstrated that the formulated nanoliposomes have a good stability during storage conditions, and they are able to control the release of phenolic compounds at different pH values. During the encapsulation process, the antioxidant activity of the algal extract has been maintained to an acceptable level. Consequently, algal extract‐loaded nanoliposomes can be used as a natural antioxidant in lipid‐based foods.
Reducing the damage of quinoa saponins on human gastric mucosal cells by a heating process
Authors: Xue Peng , Zhao Lei , Wang Yujie , Hou Zhaohua , Zhang Fengxiang , Yang Xiushi 
Published: December 2019

AbstractDifferent food processing methods will influence the structure and activity of compounds. In this work, molecular structure and different content crude saponins that were extracted from quinoa, treated with water soaking, water boiling, and water steaming were analyzed by HPLC. Flow cytometry was employed to investigate the effects of the main saponins on the GES‐1 cell line. HPLC/MS analysis revealed that water soaking induced an extensive conversion of polar saponin Qc (424.41 ± 21.11 mg/g) to the less polar compound Qf (247.04 ± 15.71 mg/g). After treatment with 100 μg of Qf instead of Qc for 24 hr, the percentage of dead cells increased from 20.1 ± 2.2% to 86.2 ± 4.8%. One major reason of this result is that less polar saponins could damage membrane integrity more easier than polar saponins. The results indicate that saponin toxicity is enhanced after degradation, so it is necessary to avoid degradation before use.