bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Characteristics of Bread Produced from Wheat and White Kidney Bean Composite Flour
Authors: Ukeyima M. T. , Dendegh T. A. , Isusu S. E. 
Published: November 2019

Aim: To evaluate the Quality characteristics of Bread produced from Wheat and Kidney Bean composite flour blend.
Study Design: Composite bread was produced from wheat and kidney bean flour of various proportions (10, 15, 20 and 25%). Proximate (protein, ash, moisture, fibre, fat and carbohydrate) composition, functional (Bulk density, foaming capacity, swelling index, water absorption capacity and oil absorption capacity) properties and sensory (appearance, taste, flavour, texture and overall acceptability) attributes were determined.
Results: Bread was produced from wheat and kidney beans composite (B, C, D and E) flour. The bread samples were subjected to physical, proximate and sensory analyses. The functional properties of the composite flour blends were also determined. The functional properties shows a significant (P<0.05) difference in water absorption capacity, oil absorption capacity and swelling index with values ranged from 1.10 – 0.60 ml/g, 1.03 – 0.76 ml/g and 5.92 – 2.89 ml/g respectively. The bulk density and foaming capacity shows significant (P<0.05) difference with its values ranging from 0.90 – 0.97 g/ml and 32.69 – 26.94 cm3 respectively as kidney beans flour increases. The result of the physical properties shows significant (P<0.05) difference in dough height, proofing rate, loaf volume, specific volume, baking loss and oven spring with values ranging from 1.169 – 3.39 cm3, 0.01 – 0.02 cm3/min, 0.79 – 1.19 cm3, 0.32 – 0.48 cm3/g, 1.59 – 2.79 and 101.58 – 102.79 respectively while the loaf weight ranged from 243.21 – 246.09 g. proximate composition of the sample were also analyzed and the result shows significant (P<0.05) difference in crude protein, moisture content, ash, crude fat, crude fibre and carbohydrate with values ranging from 8.36 – 10.47%, 22.18 – 23.28%, 0.97 – 1.38%, 11.80 – 12.94%, 0.29 – 0.59% and 51.33 – 57.10% respectively. The results of the sensory scores shows a significant (P<0.05) difference in all the samples analyzed. However, sample C with 15% kidney beans flour was most preferred.
Conclusion: It could be concluded that increased in kidney beans flour addition in the production of composite bread had significant (P<0.05) impact on the proximate, physical and organoleptic properties of the bread. Hence, 85% wheat to 15% kidney bean flour should be used in bread making.
Investigating the Relationship between New Diagnostic Technology and Information Technology in Diagnosing Cancer: Focusing on Breast Cancer
Authors: Farzan Nina , Nafissi Nahid , Yaser Foroghi Seyyed , Sadat Madani Shima , Zaheri Mohammad Mahdi , Saghafinya Samine , Shahjooie Fahimeh 
Published: November 2019

Introduction: The use of computer-assisted diagnostic tools has increased dramatically in various fields of medicine, especially cancer. It is essential and inevitable to use these tools, especially when there is a need to process large volumes of data, but new diagnostic methods was based on the use of Nano-sensors that have many advantages and they can be used to diagnose breast cancer, one of the most common neoplastic malignancies in the world. The study aims to investigate the relationship between new diagnostic methods and information technology in cancer diagnosis by categorizing research topics and important known aspects of cancer related illness from 1984 to 2017.
Methods: The evaluation conducted in March 2018 and used to access the articles on diagnostic and therapeutic methods from the PubMed, Medline, and Cochran library, WHO, Iranmedex and PsycINFO databases.
Results: The findings of this study in two sections of cancer and biological sensors show that biomarkers detect disease, and health information technology is expanding and innovating new methods. This can play an important role in managing chronic diseases such as cancer.
Conclusion: Primal diagnosis, reducing the time to diagnose and improving the quality of care during treatment, is one of the health’s information technology (IT) benefits of diagnosing cancer. In general, the results this study indicate that the use of information technology to increase the speed of effective therapeutic stages. Resulting in general health, as well as the relationship of information technology with diagnostic and therapeutic methods in our country can greatly increase the level of health and well-being and development, and create a new way of linking information technology and new diagnostic methods to cancer.
CULTUREMAS DA GASTRONOMIA CEARENSE: MARCAS DE IDENTIDADE LINGUÍSTICA E CULTURAL | CULTUREMS OF CEARENSE GASTRONOMY: LANGUAGES OF LANGUAGE AND CULTURAL IDENTITY
Authors: Costa Expedito Wellington Chaves , Marçalo Maria João 
Published: November 2019

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>Resumo: </span><span>Atualmente a língua é uma instituição social diversificada entre grupos e varia ao longo do tempo, sofrendo mudanças ou conservando características de períodos históricos. Deseja-se demonstrar que os culturemas da gastronomia cearense contribuem para a formação da identidade linguística e cutural do povo do Ceará. Para fundamentação, recorre-se, entre outros, a Pamies Bertrán (2012), Biderman (1978), e Luque Nadal (2009). Aqui, a gastronomia é inserida no âmbito da cultura imaterial por representar a tradição histórica e cultural de um povo. Metodologicamente, catalogam-se culturemas da gastronomia cearesense que se desdobram em expressões idiomáticas características do dialeto cearense. Resultados comprovam a influência dos culturemas na identidade linguística do cearense. </span></p><div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>Abstract: </span><span>Today language is a social institution diversified between groups and varies over time, undergoing changes or retaining characteristics of historical periods. It is desired to demonstrate that the Ceará gastronomic culturemas contribute to the formation of the linguistic and cutural identity of the people of Ceará. For reasons of support, we refer to, among others, Pamies Bertrán (2012), Biderman (1978), and Luque Nadal (2009). Here, gastronomy is inserted in the scope of intangible culture because it represents the historical and cultural tradition of a people. Methodologically, we catalog the cul- tures of the Cearense gastronomy that unfold in idiomatic expressions characteristic of the Ceará dialect. Results prove the influence of culturemas on the linguistic identity of Ceará. </span></p><p><span>Keywords: </span><span>Culturemas; Gastronomy; Identity; Dialect. </span></p></div></div></div></div></div></div></div>
ESTUDO ETNOLINGUÍSTICO DAS PRÁTICAS SUPERSTICIOSAS REFERENTES À MULHER GRÁVIDA NA CULTURA POPULAR DO MARANHÃO | ETHNOLINGUISTIC STUDY OF SUPERSTECTIVE PRACTICES REGARDING PREGNANT WOMEN IN POPULAR CULTURE OF MARANHÃO
Authors: Matos Heloísa Reis Curvelo 
Published: November 2019

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>Resumo</span><span>: Nossa visão de mundo diante da cultura do outro é avaliativa e carregada de criticidade. Por quê? A resposta ao questionamento buscamos na Etnolinguística, ramo da Linguística que estuda a relação entre língua, cultura e sociedade. Considerando o aporte teórico de Vasconcellos (1938), Vieira Filho (1953), Cosériu (1987) e Lima (1998), objetivamos investigar e analisar as práticas superstições referentes à mulher grávida na cultura popular do Maranhão, em municípios das Mesorregiões Norte e Leste, considerando tanto o conhecimento folclórico quanto o científico. Para tanto, fizemos pesquisa bibliográfica, entrevistas, a ficha do informante, o questionário; aplicação do questionário a 12 informantes perfiladas. Constatamos que há muitas práticas supersticiosas milenares e indiscutíveis. </span></p><div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>Abstract: </span><span>Why is our world view in the face of the Other culture evaluative and charged with criticality? The answer to this question can be found in the Ethnolinguistic field which is a Linguistic branch that studies the relation between language, culture and society. Considering the theoretical contribution of Vasconcellos (1938), Vieira Filho (1953), Cosériu (1987) and Lima (1998), we aim to investigate and analyze superstitious practices regarding pregnant women in the popular culture of Maranhão in municipalities of North and East Mesoregions, considering both the folkloric and scientific knowledge. To this end, the study was based on bibliographic research and the data collected provided by the interviews of 12 profiled informants. As a result, we found that there are many superstitious practices that are millennial and indisputable </span></p><p><span>Keywords</span><span>: </span><span>Ethnolinguistics; Maranhense popular culture; superstitious practices; pregnant woman. </span></p></div></div></div></div></div></div></div>
Rise, Fall and Reinvention: The Architect's Shifting Identity
Authors: Bayley Stephen 
Published: November 2019

AbstractTaking stock of architects' hubris in actuality and fiction, London‐based design critic and curator Stephen Bayley asks why, recently, the architect has ceased to be a clown or hero in the eyes of popular culture. He posits that the reinvention of the architect is necessary to reclaim this lost prominence, good or bad, in the eyes of the public.
Design for Sensory Reality: From Visuality to Existential Experience
Authors: Pallasmaa Juhani 
Published: November 2019

AbstractPurely ocular‐centric perception is still dominant in architectural creation. Decrying the narrowness of this approach, Finnish architect, writer and educator Juhani Pallasmaa argues for a more holistic appreciation of architecture as a way of communicating the power and embodied experience of the built environment through all the body's senses.
The Personal is Universal: On Aldo Rossi's Autobiography
Authors: Graziadei Robin Monotti 
Published: November 2019

AbstractItalian architect Aldo Rossi's rise to fame, and recognition by professionals and public alike, was predicated on him putting across his personal passions and memories of life experience. Italian‐born, London‐based architect and tutor Robin Monotti Graziadei investigates how the intertwining of architecture with the personal imperatives of the architect produced some extraordinary work.
New Architecture of the South Pacific: How the Māori Worldview is Changing New Zealand's Built Environment
Authors: Harvey Justine 
Published: November 2019

AbstractAuckland‐based architectural design writer Justine Harvey documents a new phenomenon in New Zealand's architectural community: an imperative that focuses on reflecting the Māori sensibility. This embodies respect for the land and a generous approach to interaction – giving and not taking, architecturally and socially.
‘They've Lost It’: A Balancing Act: MVRDV and the Language of Marketing
Authors: Knikker Jan 
Published: November 2019

AbstractJan Knikker spent a decade honing the public and professional image of OMA before joining MVRDV, another Rotterdam‐based international practice, in 2008 and running its business development, contracts and public relations. He describes MVRDV's corporate communications with clients, which are built on a foundation of speaking their language and being pragmatic. The downside is that not communicating in the sophist ways of the profession can alienate architects from themselves.
The Selfie of an Architect
Authors: Coates Nigel 
Published: November 2019

AbstractIn bringing his experience as an architect, teacher, founder of the avant‐garde NATO group in the 1980s, and product and interior designer, Nigel Coates lets us have his personal take on the identity of the architect while evoking the importance of an architect's education and their ownership of ideas, as well as the power of social media – not for him polite corporate mediocrity and conformity.
Oral ferroportin inhibitor VIT‐2763: First‐in‐human, phase 1 study in healthy volunteers
Authors: Richard Frank , van Lier Jan Jaap , Roubert Bernard , Haboubi Teba , Göhring Udo‐Michael , Dürrenberger Franz 
Published: November 2019

AbstractRestriction of iron availability by ferroportin inhibition is a novel approach to treating non‐transfusion‐dependent thalassemia (β‐thalassemia intermedia). This first‐in‐human, Phase I study (https://www.clinicaltrialsregister.eu; EudraCT no. 2017‐003395‐31) assessed the safety, tolerability, pharmacokinetics and pharmacodynamics of single‐ and multiple‐ascending doses (SAD and MAD) of the oral ferroportin inhibitor, VIT‐2763, in healthy volunteers. Participants received VIT‐2763 5/15/60/120/240 mg or placebo in the SAD phase and VIT‐2763 60/120 mg once daily, VIT‐2763 60/120 mg twice daily, or placebo for 7 days in the MAD phase. Seventy‐two participants completed treatment. VIT‐2763 was well tolerated and demonstrated a similar safety profile to the placebo. There were no serious or severe adverse events, or discontinuations due to adverse events. VIT‐2763 absorption was relatively fast, with detectable levels 15 to 30 minutes post‐dose. Following multiple dosing there was no apparent change in absorption and accumulation was minimal. Mean elimination half‐life was 1.9 to 5.3 hours following single dosing, and 2.1 to 3.8 hours on Day 1 and 2.6 to 5.3 hours on Day 7, following repeated dosing. There was a temporary decrease in mean serum iron levels with VIT‐2763 single doses ≥60 mg and all multiple doses; mean calculated transferrin saturation (only assessed following multiple dosing) also temporarily decreased. A shift in mean serum hepcidin peaks followed administration of all iron‐lowering doses of VIT‐2763. This effect was less pronounced after 7 days of multiple dosing (aside from with 120 mg once daily). These results support the initiation of clinical studies in patients with non‐transfusion‐dependent thalassemia and documented iron overload due to ineffective erythropoiesis.
Evolutionary selection and morphological integration in the vertebral column of modern humans
Authors: Arlegi Mikel , Veschambre‐Couture Christine , Gómez‐Olivencia Asier 
Published: November 2019

AbstractObjectivesThe main objective is to quantify integration, modularity, and response to selection in the presacral vertebral column of modern humans.Materials and methodsSeventeen linear variables on each presacral vertebra were collected in 108 modern humans producing a total of ~39,000 measurements. Then, we studied patterns and magnitudes of integration at regional, vertebral, and intra‐vertebral levels. Additionally, we calculated the ability of vertebrae to respond to selection by quantifying differences in evolvability, flexibility, and constraint throughout the spine.ResultsThe results indicate that caudal vertebrae are more evolvable than those located more cranially in the presacral vertebral column, following an increasing pattern of evolvability from the cervical to the lumbar region. Additionally, the atlas and fifth lumbar vertebra show the lowest values of integration, while central thoracic vertebrae display the highest magnitudes of integration.DiscussionThese results could be related to three main factors: body plan organization expressed by the Hox genes, the strong developmental constraints that determine the number of mammalian vertebrae, and, finally, the functional requirements of an adaptation to bipedal locomotion in the human lineage.
α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus
Authors: Adotevi Nadia , Lewczuk Ewa , Sun Huayu , Joshi Suchitra , Dabrowska Natalia , Shan Sarah , Williamson John , Kapur Jaideep 
Published: November 2019

ObjectiveGeneralized convulsive status epilepticus is associated with high mortality. We tested whether α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor plasticity plays a role in sustaining seizures, seizure generalization, and mortality observed during focal onset status epilepticus. We also determined whether modified AMPA receptors generated during status epilepticus could be targeted with a drug.MethodsElectrically induced status epilepticus was characterized by electroencephalogram and behavior in GluA1 knockout mice and in transgenic mice with selective knockdown of the GluA1 subunit in hippocampal principal neurons. Excitatory and inhibitory synaptic transmission in CA1 neurons was studied using patch clamp electrophysiology. The dose response of N,N,H,‐trimethyl‐5‐([tricyclo(3.3.1.13,7)dec‐1‐ylmethyl]amino)‐1‐pentanaminiumbromide hydrobromide (IEM‐1460), a calcium‐permeable AMPA receptor antagonist, was determined.ResultsGlobal removal of the GluA1 subunit did not affect seizure susceptibility; however, it reduced susceptibility to status epilepticus. GluA1 subunit knockout also reduced mortality, severity, and duration of status epilepticus. Absence of the GluA1 subunit prevented enhancement of glutamatergic synaptic transmission associated with status epilepticus; however, γ‐aminobutyric acidergic synaptic inhibition was compromised. Selective removal of the GluA1 subunit from hippocampal principal neurons also reduced mortality, severity, and duration of status epilepticus. IEM‐1460 rapidly terminated status epilepticus in a dose‐dependent manner.InterpretationAMPA receptor plasticity mediated by the GluA1 subunit plays a critical role in sustaining and amplifying seizure activity and contributes to mortality. Calcium‐permeable AMPA receptors modified during status epilepticus can be inhibited to terminate status epilepticus. ANN NEUROL 2020;87:84–96
Conjugated Copper–Catecholate Framework Electrodes for Efficient Energy Storage
Authors: Liu Jingjuan , Zhou Yi , Xie Zhen , Li Yang , Liu Yunpeng , Sun Jie , Ma Yanhang , Terasaki Osamu , Chen Long 
Published: November 2019

AbstractA conjugated copper(II) catecholate based metal–organic framework (namely Cu‐DBC) was prepared using a D2‐symmetric redox‐active ligand in a copper bis(dihydroxy) coordination geometry. The π‐d conjugated framework exhibits typical semiconducting behavior with a high electrical conductivity of ca. 1.0 S m−1 at room temperature. Benefiting from the good electrical conductivity and the excellent redox reversibility of both ligand and copper centers, Cu‐DBC electrode features superior capacitor performances with gravimetric capacitance up to 479 F g−1 at a discharge rate of 0.2 A g−1. Moreover, the symmetric solid‐state supercapacitor of Cu‐DBC exhibits high areal (879 mF cm−2) and volumetric (22 F cm−3) capacitances, as well as good rate capability. These metrics are superior to most reported MOF‐based supercapacitors, demonstrating promising applications in energy‐storage devices.
Simulation vs. Understanding: A Tension, in Quantum Chemistry and Beyond. Part C. Toward Consilience
Authors: Hoffmann Roald , Malrieu Jean‐Paul 
Published: November 2019

AbstractIn the last part of our Essay, we outline a future of consilience, with a role both for fact‐seekers, and for searchers for understanding. We begin by looking at theory and simulation, surrounded as they are by and interacting with experiment, especially in Chemistry. Experimenters ask questions both conceptual and numerical, and so draw the communities together. Two case studies show what brings the theoretician authors joy in this playground, and two more detailed ones make it clear that computation/simulation is anyway deeply intertwined with theory‐building in what we do, or for that matter, anywhere in the profession. From a definition of science we try to foresee how simulation and theory will interact in the AI‐dominated future. We posit that Chemistry's streak of creation provides in that conjoined future a link to Art, and a passage to a renewed vision of the sacred in science.
Indandione‐Terminated Quinoids: Facile Synthesis by Alkoxide‐Mediated Rearrangement Reaction and Semiconducting Properties
Authors: Du Tian , Gao Ruiheng , Deng Yunfeng , Wang Cheng , Zhou Qian , Geng Yanhou 
Published: November 2019

AbstractA series of 1,3‐indandione‐terminated π‐conjugated quinoids were synthesized by alkoxide‐mediated rearrangement reaction of the respective alkene precursors, followed by air oxidation. This new protocol allows access to quinoidal compounds with variable termini and cores. The resulting quinoids all show LUMO levels below −4.0 eV and molar extinction coefficients above 105 L mol−1 cm−1. The optoelectronic properties of these compounds can be regulated by tuning the central cores as well as the aryl termini ascribed to the delocalized frontier molecular orbitals over the entire molecular skeleton involving aryl termini. n‐Channel organic thin‐film transistors with electron mobility of up to 0.38 cm2 V−1 s−1 were fabricated, showing the potential of this new class of quinoids as organic semiconductors.
Blending chitosan‐g‐poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications
Authors: de Cassan Dominik , Becker Alexander , Glasmacher Birgit , Roger Yvonne , Hoffmann Andrea , Gengenbach Thomas R. , Easton Christopher D. , Hänsch Robert , Menzel Henning 
Published: November 2019

ABSTRACTUse of electrospun fiber mats for tissue engineering applications has become increasingly prominent. One of the most important polymers in research, poly(ε‐caprolactone) (PCL), however, lacks biological performance, easy access to modifications and cellular recognition sites. To improve these properties and to enable further modifications, PCL was blended with chitosan grafted with PCL (CS‐g‐PCL) and subsequently processed via electrospinning. In this way, chitosan was enriched at the fiber's surface presenting cationic amino groups. The fiber mats were analyzed by various techniques such as scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and X‐ray photoelectron spectroscopy (XPS). Furthermore, analyzing thermal properties and crystallinity, showed that an increased content of CS‐g‐PCL in blend composition leads to a higher overall crystallinity in produced fiber mats. Blending CS‐g‐PCL into PCL significantly increased initial cellular attachment and proliferation as well as cell vitality, while maintaining adequate mechanical properties, fiber diameter, and interstitial volume. As proof of principle for easy access to further modification, fluorescently labeled alginate (Alg‐FA) was attached to the fiber's surface and verified by CLSM. Hence, blending CS‐g‐PCL with PCL can overcome an inherent weakness of PCL and create bioactive implants for tissue engineering applications. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48650.