bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS
Authors: Zhu Shaochun , Wuolikainen Anna , Wu Junfang , Öhman Anders , Wingsle Gunnar , Moritz Thomas , Andersen Peter M. , Forsgren Lars , Trupp Miles 
Published: November 2019

Abstract
The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) share some common molecular deficits including disruption of protein homeostasis leading to disease-specific protein aggregation. While insoluble protein aggregates are the defining pathological confirmation of diagnosis, patient stratification based on early molecular etiologies may identify distinct subgroups within a clinical diagnosis that would respond differently in therapeutic development programs. We are developing targeted multiple reaction monitoring (MRM) mass spectrometry methods to rigorously quantify CSF proteins from known disease genes involved in lysosomal, ubiquitin-proteasomal, and autophagy pathways. Analysis of CSF from 21 PD, 21 ALS, and 25 control patients, rigorously matched for gender, age, and age of sample, revealed significant changes in peptide levels between PD, ALS, and control. In patients with PD, levels of two peptides for chromogranin B (CHGB, secretogranin 1) were significantly reduced. In CSF of patients with ALS, levels of two peptides from ubiquitin carboxy-terminal hydrolase like protein 1 (UCHL1) and one peptide each for glycoprotein non-metastatic melanoma protein B (GPNMB) and cathepsin D (CTSD) were all increased. Analysis of patients with ALS separated into two groups based on length of survival after CSF sampling revealed that the increases in GPNMB and UCHL1 were specific for short-lived ALS patients. While analysis of additional cohorts is required to validate these candidate biomarkers, this study suggests methods for stratification of ALS patients for clinical trials and identifies targets for drug efficacy measurements during therapeutic development.
Infantile Onset of Spinocerebellar Ataxia Type 5 (SCA-5) in a 6 Month Old with Ataxic Cerebral Palsy
Authors: Rea Gillian , Tirupathi Sandya , Williams Jonathan , Clouston Penny , Morrison Patrick J. 
Published: November 2019

Abstract
Spinocerebellar ataxia type 5 (SCA-5) is a predominantly slowly progressive adult onset ataxia. We describe a child with a presentation of ataxic cerebral palsy (CP) and developmental delay at 6 months of age. Genetic testing confirmed a c.812C>T p.(Thr271Ile) mutation within the SPTBN2 gene. Seven previous cases of infantile onset SCA-5 are reported in the literature, four of which had a CP presentation. Early onset of SCA-5 presents with ataxic CP and is a rare cause of cerebral palsy.
Flood Frequency Analysis of the Rapti River Basin using Log Pearson Type-III and Gumbel Extreme Value-1 Methods
Authors: Kumar Rajesh 
Published: November 2019

ABSTRACT
Flooding is a widespread, frequent and most disastrous natural hazard around the globe. Flood frequency analysis is a necessary step for floodplain zoning and planning of the dams, bridges, culverts, embankments and anti-erosion structures along or across a river. In the Rapti river basin, the flood frequency analysis has been performed using the annual maxima series of discharges recorded at Jalkundi and Birdghat (Gorakhpur) gauge and discharge (G/D) sites with the help of Log Pearson Type-III (LP-III) and Gumbel Extreme Value -1 (EV1) methods. The flood discharges at 25, 50, 100, 200, 500 and 1000 year return periods are lower at Birdghat than those at Jalkundi. Such a reverse scenario indicates storage of flood waters in the Rapti floodplain near and upstream of Birdghat G/D site. The Kolmogorov-Smirnov (K-S) and Anderson-Darling (A-D) tests have been applied on the annual maxima series of discharge data to identify the appropriate curve fitting models, namely LP-III and EV1. The goodness-of-fit analysis shows that the LP-III method is more appropriate for flood frequency analysis than the EV1 at above mentioned G/D sites.
Hydrochemistry of Groundwater from Chevella Watershed, Telangana State, India
Authors: Podila Sankara Pitchaiah , Penumaka Ramesh , Cherukuri Israel 
Published: November 2019

ABSTRACT
Hydrochemical studies are useful to understand the variation of chemical facies and interaction between water and host rock. 88 groundwater samples were collected from Chevella sub-basin, Telangana state, during the pre and post monsoon seasons of 2009 and 2013 and subjected to the chemical analysis. Chadhas’ hydrochemical diagram was used to study the chemical facies. Statistical correlation and ‘t’ test were carried out to understand the relation between various chemical parameters and to study the variation between seasons. The study found that there is a dilution of almost all the chemical parameters temporally. It is also identified that the groundwater of the Chevella sub- basin is Ca2+– Mg2+– Cl- type. A highly significant correlation is found between pre and post 2009, pre and post 2013 and pre 2009 and post 2013. The ‘T-test’ values indicate that all the cations and anions were decreased in concentration from pre and post monsoon 2009 to 2013. It is attributed to the spacial and temporal variations, i.e., rainfall, creation of water harvesting structures and sufficient time to recharge. The study proved that ground water quality and chemistry can be improved by creating suitable RHS.
A Framework for Considering Climate Change Impacts in Project Selection for Deepwater Horizon Restoration Efforts
Authors: Carl Kraft Bethany , Crandall Raelene 
Published: November 2019

Abstract
The 2010 Deepwater Horizon (DWH) oil spill resulted in extensive damage to the northern Gulf of Mexico ecosystem. Resulting fines and penalties have triggered one of the largest ecological restoration efforts in U.S. history. Nearly $20 Billion in funding from oil spill-related claims and settlements will be available in the coming years for environmental restoration and economic recovery. At the same time, climate change is also impacting ecosystem form and function in the Gulf region, which could undermine the long-term sustainability of projects by limiting their useful life or impeding anticipated benefits over time (e.g., ecosystem services, flood protection). These challenges can be considered and addressed in project planning, selection and adaptive management phases of restoration. If decision-makers do not consider the longevity of projects in the face of climate-related stressors, in 30 to 50 years there could be very little to show for a $20 Billion investment, with the Gulf ecosystem still in need of extensive restoration but without the monetary resources to accomplish restoration goals and mitigate climate-related impacts. This paper provides a framework for decision makers to consider how to incorporate climate change considerations for wetland restoration activities related to the DWH spill.
Improving dialogue among researchers, local and indigenous peoples and decision-makers to address issues of climate change in the North
Authors: Callaghan Terry V. , Kulikova Olga , Rakhmanova Lidia , Topp-Jørgensen Elmer , Labba Niklas , Kuhmanen Lars-Anders , Kirpotin Sergey , Shaduyko Olga , Burgess Henry , Rautio Arja , Hindshaw Ruth S. , Golubyatnikov Leonid L. , Marshall Gareth J. , Lobanov Andrey , Soromotin Andrey , Sokolov Alexander , Sokolova Natalia , Filant Praskovia , Johansson Margareta 
Published: November 2019

Abstract
The Circumpolar North has been changing rapidly within the last decades, and the socioeconomic systems of the Eurasian Arctic and Siberia in particular have displayed the most dramatic changes. Here, anthropogenic drivers of environmental change such as migration and industrialization are added to climate-induced changes in the natural environment such as permafrost thawing and increased frequency of extreme events. Understanding and adapting to both types of changes are important to local and indigenous peoples in the Arctic and for the wider global community due to transboundary connectivity. As local and indigenous peoples, decision-makers and scientists perceive changes and impacts differently and often fail to communicate efficiently to respond to changes adequately, we convened a meeting of the three groups in Salekhard in 2017. The outcomes of the meeting include perceptions of how the three groups each perceive the main issues affecting health and well-being and recommendations for working together better.
Banana peel biochar as alternative source of potassium for plant productivity and sustainable agriculture
Authors: Islam Mahmuda , Halder M. , Siddique Md. A. B. , Razir S. A. A. , Sikder S. , Joardar J. C. 
Published: November 2019

Abstract

Purpose
Biochar addition to soil is immensely beneficial for increasing plant productivity and C sequestration, attenuating nutrient leaching loss, counteracting heavy metal contamination and organic waste triggered environmental pollution. To understand the sustainable benefits of biochar, two pot experiments were conducted under net house condition in Khulna University, Bangladesh.

Methods
Biochar was prepared from banana peel waste through slow pyrolysis process under limited oxygen condition. Three lower rates (1, 2 and 3%) of banana peel biochar (BPB) were added with agricultural soil along with control with three replications for each. After incorporation of BPB into soil, pots were kept under field condition for 7 days and then the seeds of Ipomoea aquatica were sown. Plants were harvested after 42 days from seeds sowing and plant height, leaf number, fresh weight, and dry weight were measured. Another pot experiment was also conducted under sand medium to test the BPB as K-rich soil amendment where K was applied from two different sources (KCl and BPB) along with control. Seeds of Cucurbita moschata were sown and 40 days after seed sowing, K deficiency was observed in control treatments.

Results
Banana peel biochar was found to be rich in K content. Plant productivity and above-ground biomass were reduced in 1% BPB treatments, but increased in 2 and 3% BPB treatments as compared to control but statistically insignificant (p < 0.05). In case of second experiment, K deficiency symptoms were observed in 40 days aged Cucurbita moschata seedlings under control treatments, whereas no K deficiency symptom was noticed in plants grown under K supplied from both KCl and BPB. Moreover, the plant grown with BPB was found healthy, stronger and greener in appearance.

Conclusion
This positive influence of BPB on plant growth suggests the alternative way to overcome the use of chemical fertilizer and effective way of utilization of agricultural wastes through recycling.
Comparative study on bearing mechanism and design parameters of confined concrete arch joints in deep soft rock roadway
Authors: Lu Wei , Wang Qi , Jiang Bei , Xu Shuo , Liu Bohong , Zhang Peng , Jiang Zhenhua 
Published: November 2019

Abstract
Square confined concrete arch is increasingly used in deep soft rock roadway support because of its advantages of high strength and construction convenience. However, the design of confined concrete arch in underground engineering still remains in experience-based method and lacks quantitative analysis. As a connecting component between arch sections, the connection joints have an important influence on the internal force distribution and failure mechanism of support arch. Therefore, a reasonable design of arch joints is the premise of rational support design. Taking Liangjia Coal Mine, a typical deep soft rock mine in China, as research background, this paper fully compared the most widely used joint types of confined concrete arch as analytical objects: flange joints and casing joints. The main failure modes of these two kinds of joints under bending moment are defined. Laboratory and numerical tests are carried out to study the mechanical characteristics of joints. Based on the M–θ curve, the influence law of different design parameters is analyzed, and the design principles of joints are proposed. The research results could provide a theoretical basis for the design and application of confined concrete arch in related projects.
Spatial long memory
Authors: Robinson Peter M. 
Published: November 2019

AbstractWe discuss developments and future prospects for statistical modeling and inference for spatial data that have long memory. While a number of contributons have been made, the literature is relatively small and scattered, compared to the literatures on long memory time series on the one hand, and spatial data with short memory on the other. Thus, over several topics, our discussions frequently begin by surveying relevant work in these areas that might be extended in a long memory spatial setting.
Electroporation of outer membrane vesicles derived from Pseudomonas aeruginosa with gold nanoparticles
Authors: Ayed Zeineb , Cuvillier Luana , Dobhal Garima , Goreham Renee V. 
Published: November 2019

Abstract
Since their discovery, extracellular vesicles have gained considerable scientific interest as a novel drug delivery system. In particular, outer membrane vesicles (OMVs) play a critical role in bacteria–bacteria communication and bacteria–host interactions by trafficking cell signalling biochemicals (i.e. DNA, RNA, proteins). Although previous studies have focused on the use of OMVs as vaccines, little work has been done on loading them with functional nanomaterials for drug delivery. We have developed a novel drug delivery system by loading OMVs with gold nanoparticles (AuNPs). AuNPs are versatile nanoparticles that have been extensively used in disease therapeutics. The particles were loaded into the vesicles via electroporation, which uses an electric pulse to create a short-lived electric field. The resulting capacitance on the membrane generates pores in the lipid bilayer of the OMVs allowing AuNPs (or any nanoparticle under 10 nm) inside the vesicles. Closure of the pores of the lipid membrane of the OMVs entraps the nanoparticles as cargo. Transmission electron microscopy was used to confirm the loading of AuNPs inside the OMVs and dynamic light scattering (DLS) and cryogenic scanning electron microscopy (cryo-SEM) verified the size and integrity of the OMVs. This is the first report to load nanoparticles into OMVs, demonstrating a potential method for drug delivery.

Graphic abstract
Linking bedrock discontinuities to glacial quarrying
Authors: Woodard J. B. , Zoet L. K. , Iverson N. R. , Helanow C. 
Published: November 2019

AbstractQuarrying and abrasion are the two principal processes responsible for glacial erosion of bedrock. The morphologies of glacier hard beds depend on the relative effectiveness of these two processes, as abrasion tends to smooth bedrock surfaces and quarrying tends to roughen them. Here we analyze concentrations of bedrock discontinuities in the Tsanfleuron forefield, Switzerland, to help determine the geologic conditions that favor glacial quarrying over abrasion. Aerial discontinuity concentrations are measured from scaled drone-based photos where fractures and bedding planes in the bedrock are manually mapped. A Tukey honest significant difference test indicates that aerial concentration of bed-normal bedrock discontinuities is not significantly different between quarried and non-quarried areas of the forefield. Thus, an alternative explanation is needed to account for the spatial variability of quarried areas. To investigate the role that bed-parallel discontinuities might play in quarrying, we use a finite element model to simulate bed-normal fracture propagation within a stepped bed with different step heights. Results indicate that higher steps (larger spacing of bed-parallel discontinuities) propagate bed-normal fractures more readily than smaller steps. Thus, the spacing of bed-parallel discontinuities could exert strong control on quarrying by determining the rate that blocks can be loosened from the host rock.
Transformative Vision of Islamic Jurisprudence and the Pursuit of Common Ground for the Social Good in Pluralist Societies
Authors: ELMAHJUB Ezieddin 
Published: November 2019

AbstractNotions of the social good including rights, fairness, and economic efficiency influence our choices of law and policymaking. The discussion on social good is normally a heated one in pluralistic societies with multiple worldviews on the right thing to do. This article brings a novel Islamic perspective on the social good in pluralistic societies. In doing so, it makes and defends three propositions: first, religious notions of the social good, including those derived from the Islamic worldview, should not be excluded from public justifications when making moral and policy choices. There is no good reason for plural/secular societies to reject the benefits of religious presence in public discourse given the overwhelming evidence on religious precepts being a mobilizing force to promote co-existence and social cooperation. Second, Islamic notions of social good can contribute to that end. The article criticizes the common perception of Islamic ethics that views Islamic doctrine as a rigid positivist system which imposes inflexible moral codes limiting the influence of independent human intellect and agency. I show that Islamic notions of the social good are dynamic and adaptable to change. The third part of the article shows that the social good in Islamic doctrine has always been defined with reference to essential human needs, including the promotion of life, intellect, social cooperation, and justice. At their core, Islamic notions of the social good exhibit an overarching deontological orientation towards moral choices. They broadly overlap with comparative and influential frameworks on human flourishing, including the ‘Human Development Paradigm’ and the ‘Capabilities Approach’.
Horizontal Differentiation and Determinants of Wine Exports: Evidence from Portugal
Authors: Macedo Anthony , Gouveia Sofia , Rebelo João 
Published: November 2019

AbstractAssuming horizontal differentiation and using an expanded gravity model, the main objective of this article is to assess the determinants of Portuguese wine exports. Horizontal differentiation is considered, with still and fortified wines being distinguished, as well as three distinct designations of origin: Vinho Verde, Douro, and Port wines. The results from the period between 2006 and 2016 suggest that wineries and private and public agencies should focus their commercial and policy efforts on countries with high purchasing power and/or with great potential for growth, regardless of whether the customs costs are higher. Moreover, it is concluded that horizontal differentiation influences the export determinants, suggesting there should exist different internationalization strategies for distinct types of wine. (JEL Classifications: F10, F14, L66)
Dualization and Electoral Realignment
Authors: Häusermann Silja 
Published: November 2019

AbstractThe growing research on post-industrial labor market inequality bears a strong—yet widely misunderstood—relevance for the literature on electoral realignment. In this contribution, I contend that the assumption of “labor market outsiders” being equal to “globalization/modernization losers” is largely mistaken. Rather, atypical work and unemployment is most widespread among service workers, whose primary electoral choice is to abstain from voting. This implies that the ongoing reconfiguration of European party systems—through the rise of right-wing populist parties—is driven by skilled and routine workers in the manufacturing sector (the traditional “insiders”). Hence, the rise of right-wing populist parties reflects a political mobilization of the formerly well-protected industrial working class, rather than of labor market outsiders.
A countervailing atonement: The meaning of equivalence in the American moral governmental theory of the atonement
Authors: Todd Obbie Tyler 
Published: November 2019

AbstractIn the American moral governmental theory of the atonement, the idea of equivalence is best understood in terms of a countervailing, or the achieving of a moral equilibrium. According to Jonathan Edwards’ disciples, Christ's atonement was not quantifiably equivalent to the penalty of the law, but morally and meaningfully equivalent. In other words, Christ's physical and psychological sufferings were not equal in amount or degree to a sinner's damnation. Rather, Christ's substitution for divine punishment exhibited sufficient displeasure against sin to effectively communicate his character and to offset the evil effects of sin. At stake was not the moral quantity of his crucifixion, but the moral quality. In this moral governmental scheme, Christ's was not a commutative atonement, but a countervailing atonement.
Theological interpretation of non-biblical texts
Authors: Sarisky Darren 
Published: November 2019

AbstractAgainst the backdrop of the debate about theological reading of scripture, this essay asks whether there ought to be theological interpretation of non-biblical texts. The claim is that there should be, since theology can serve as an encompassing framework that structures all of one's beliefs. On this view, non-biblical literary texts function as a set of non-privileged signs pointing toward the Christian God. These texts should therefore be read using a reading strategy that relates them to God. This raises some complexities in the argument, however, because if these texts not only do not form part of the biblical canon, but also are different in content from those that do, then it is not straightforward how they can be read with reference to the Christian God. The essay wrestles with this issue as well as the objection that the proposal advocates a version of natural theology.
Neo-traditionalist ecclesiology in Orthodoxy
Authors: Ladouceur Paul 
Published: November 2019

AbstractModern anti-ecumenism in Orthodoxy is grounded in a sacramental or eucharistic ecclesiology which identifies Christianity and the church exclusively with the Orthodox Church and stands in opposition to universal baptismal ecclesiology. This neo-traditionalist ecclesiology stresses the unity of the sacraments of baptism, chrismation and eucharist as equally necessary for membership in the church, identified exclusively with the Orthodox Church. It exploits a weakness in Orthodox eucharistic ecclesiology, according to which the church, identified with the Orthodox eucharistic community, can be interpreted as excluding non-Orthodox Christians from the church. The article demonstrates that this anti-ecumenical, exclusivist ecclesiology is contrary to several major aspects of the Orthodox tradition.
The Reformers as fathers of the church: Luther and Calvin in the thought of Karl Barth
Authors: Bender Kimlyn J. 
Published: November 2019

AbstractKarl Barth's understanding of Luther and Calvin is not best illumined by an examination of his direct citation of their work, but by a consideration of his description of their vocation as church fathers as outlined in Church Dogmatics, I/2, a position held with remarkable consistency over the course of his career. Barth's discussion of Luther and Calvin there not only sets forth his understanding of the Reformers in a historical genealogy of revelation and its witnesses, but places them in an ordering of church authorities. Moreover, his description of their unique vocation sheds important light upon his understanding of the modern discipline of church history itself. His treatment of the Reformers thus both exemplifies and follows from his conviction that church history is not an independent theological discipline but can only accompany the central disciplines of exegetical, dogmatic and practical theology.