bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFESIONALISME PUSTAKAWAN DALAM LAYANAN INFORMASI
Authors: Anawati Sri 
Published: November 2019

<p>Advances in science and technology are increasingly causing increased the need<br />and demand pemustaka. Here librarians are required to be able to answer these<br />challenges, in order to meet the needs user. Librarian is a profession that requires education or training to manage the library. The professionalism of librarians should be increased because the librarian is an important element in the library. If the library does not want to be left pemustaka and want to continue to progress and evolve, the librarian should develop a professional attitude in order to create a positive image. A professional librarian who not only required to master the skill and technique of the library, but his soul felt called to become a librarian and aware that the profession of librarian is the servant of the library patron.</p><p><br />Keywords: librarians , professionalism , service information</p>
As Industry Changes, So Does Petroleum Engineering Education
Authors: Feder Judy 
Published: November 2019

As the oil and gas industry becomes increasingly complex, the requirements for petroleum engineers—and petroleum engineering education—are changing.
“Petroleum engineering jobs in the future are likely to be smaller in number and radically different from those of today,” wrote Nathan Meehan, president of Gaffney, Cline and Associates and 2016 SPE President, in paper SPE•194746, The End of Petroleum Engineering As We Know It. “The next generation of petroleum engineers will have to address demands for sustainability, lower carbon intensity, and needs for radical productivity improvements, which only artificial intelligence (AI) and digital can drive. This suggests that we will need to revisit university education for petroleum engineers and all aspects of career development and•training.”
Petroleum engineering education reflects the E&P industry it serves. Training of competent graduates with both the domain and digital knowledge to immediately contribute when they join the industry has become more complicated as expectations change. What are petroleum engineering schools doing to adapt to these changes, and how are they helping their students navigate a future career in the oil and gas industry?
Balancing Theory and Practical Application
A survey by Ryder Scott Petroleum Consultants identified the need to modify the skills and knowledge currently taught in academic institutions during undergraduate study. Ryder Scott surveyed clients who were industry managers or supervisors with direct experience with newly minted petroleum engineering graduates (fewer than 5 years of experience). The survey asked participants—engineering managers in the oil and gas reserves sector—their opinions regarding the preparedness of recent graduates entering the workforce (Fig. 1).
Generally, the respondents were satisfied with the amount of theory being taught, but not with the amount of practical application of petroleum engineering principles. The consensus was that curricula should be kept the same in terms of courses, but modernized to include the practical application of new technologies.
This presents a significant challenge for engineering education programs whose already-full curricula to meet requirements of the Accreditation Board of Engineering and Technology (ABET) leave little room for additional coursework, labs, or field work. The current requirement for a BS degree in petroleum engineering at most schools is 130-plus credit hours. Yet, in addition to fundamentals, today’s graduates are expected to be fluent in data analytics, machine learning, and data sciences and to understand concepts such as cyber security and physical security. In addition, many are expected to use their subsurface engineering skills to plan and design carbon sequestration solutions.
“We teach students the fundamentals of petroleum engineering,” said Jeff Spath, SPE 2014 President and head of the Texas A&M University Petroleum Engineering Department. “But more importantly, we teach them to solve petroleum engineering problems.”
Technology Focus: Production and Facilities (December 2019)
Authors: Frankiewicz Ted 
Published: November 2019

Technology Focus
Innovation is alive and well in our industry, as evidenced by this year’s feature selections. The major thrust of papers relating to production and facilities continue to be big data analytics, process and field optimization, piping and pipelining, and the performance of inflow-control devices (ICDs and autonomous ICDs, or AICDs).
For ICDs and AICDs, publications have evolved from descriptions of the devices and how they work to field reports of their successful implementation. As with most new technologies, their degree and frequency of success are rapidly improving. Progress is exemplified by efforts to couple ICD/AICD installations with reservoir simulation (paper SPE 193364), thus giving technologists the ability to develop and digitally test placement models for ICD/AICD devices.• One paper (SPE 195450) reports on the completion of three wells in one formation. The well with ICDs outperformed the wells with a slotted liner or•perforations. •
For big data analytics, novel development work continues to focus on improving algorithms for directing preventative maintenance and risk-based inspections with fewer false-positive alarms. This technology has even begun migrating from the research and development stage by operators to use by service companies. One step-out application of big data analytics is the use of autonomous ground vehicles for the monitoring of buried onshore pipelines (paper SPE 192773). This allows for much more sophisticated pipeline inspections with far less health, safety, and environmental exposure.•
A project-management paper deserving attention describes a successful multiteam project with emphasis on interdisciplinary communication. The objective was to construct and start up a large liquefied natural gas train. The project involved 370 deliverables with over 7,000 unique line items (paper SPE•191984).
Other papers describing creative new technology include the testing of nano-paint-aided electromagnetic pigging of pipelines and production tubing (paper SPE 196112), a tetherless autonomous device capable of traveling with or against production flow to accomplish pigging and inspection (paper SPE• 195709), and the use of a solid propellant accumulator for activating blowout preventers (paper OTC 29151). These and a number of other publications are great examples of creative work on nascent technologies to improve all aspects of oil and gas production.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 191984 Facility Operations Readiness and Project Startup Support and Integration by Michael Maher, ConocoPhillips
SPE 196112 Nanopaint-Aided Electromagnetic Pigging in Pipelines and Production Tubing by Ningyu Wang, The University of Texas at Austin, et al.
OTC 29151 Solid Propellant Accumulators—Next-Generation Hydraulic•Power Source for Cold-Weather BOPs by Nazareth Bedrossian, Bastion Technologies
Technology Focus: Bits and Bottomhole Assemblies
Authors: Mensa-Wilmot Graham 
Published: November 2019

Technology Focus
Drilling vibration continues to preoccupy the industry’s attention, primarily because of its known detrimental effects on operational efficiency, downhole tool reliability, cycle time, and project cost. In addition to drill bits and bottomhole assemblies that have been known to initiate vibrations, researchers have identified several other conditions and factors with similar contributions to vibration initiation. Vibration challenges, if effectively addressed, will have strong positive effects on performance.
The debate on whether the industry is doing enough to address vibrations continues to linger. This discussion must be put to rest because the fact is that researchers are passionately obsessed with this challenge. Presently, the focus has shifted from mere awareness to efforts that seek to establish a deeper understanding of this subject. In addition to identifying and characterizing different vibration modes, the current emphasis also delves into their sources. Knowledge gained from these efforts, particularly awareness of the different factors contributing to vibration, is driving development of holistic solutions to the challenge.
Numerous initiatives, including downhole tool development for data acquisition, big data and analytics, innovative modeling techniques, and calibration and optimization of modeling results, have been deployed in this effort. Positive results with measurable effects in field operations have been achieved. In all cases, development of effective solutions must start with appropriate characterization and identification of the specific modes of vibration. Its sources must also be established so that developed solutions can be tailored for maximum effectiveness.•
The holistic approach has identified borehole spiraling, especially in long lateral sections, as a primary source of vibrations and other drilling challenges. Solutions to address this challenge are currently in development. Yes, we continue to seek effective solutions to address the problem. However, we always encounter new challenges as we drill deeper into harsher environments, increase dogleg-severity requirements, and extend our departures while also drilling highly heterogeneous formations. We cannot stand still; we must keep moving ahead.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 196020 Case Studies: Optimizing BHA Performance by Leveraging Data and Advanced Modeling by Mojtaba Shahri, Apache, et al.
SPE 194120 Mitigation of Multifrequency Stick/Slip by Zhijie Sun, Halliburton, et al.
SPE 194150 Industry’s First PDC Bit Gauge Design for Improved Tracking In North American Horizontal Wells by Reed Spencer, Baker Hughes, a GE Company, et•al.
Silencing of the DJ-1 (PARK7) gene sensitizes pancreatic cancer to erlotinib inhibition
Authors: He Xiangyi , Sun Yunwei , Fan Rong , Sun jing , Zou Douwu , Yuan Yaozong 
Published: November 2019

Abstract
Background:
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib, in combination with gemcitabine, has been shown to be a promising therapy in the treatment of pancreatic cancer. Our previous study showed that DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. The aim of this study was to evaluate whether silencing DJ-1 expression can sensitize pancreatic cancer cells to erlotinib treatment.
METHODS:
Knockdown of DJ-1 expression, combined with erlotinib treatment, was performed in the pancreatic cancer cell lines BxPC-3, PANC-1 and MiaPACa-2. Cell proliferation was assessed with the CCK-8 assay and BrdU incorporation, while apoptosis was measured using terminal deoxynucleotidyl ransferase (TdT)-mediated dUTP nick-end labeling. RAS activity and activation of the downstream pathways involving AKT and ERK1/2 were explored to determine the underlying mechanism.
RESULTS:
Knockdown of DJ-1 expression accelerated erlotinib-induced cell apoptosis, and improved the inhibitory effect of erlotinib on pancreatic cancer cell proliferation in vitro and in xenograft tumor growth in vivo . Knockdown of DJ-1 decreased K-RAS expression, membrane translocation, and activity in BxPC-3 cells. Knockdown of DJ-1 also decreased K-RAS, H-RAS, and N-RAS expression in PANC-1 and MiaPACa-2 cells. Knockdown of DJ-1 synergistically inhibited AKT and ERK1/2 phosphorylation with erlotinib in pancreatic cancer cells.
CONCLUSIONS:
DJ-1 may activate the RAS pathway, reinforcing erlotinib drug resistance. Blocking DJ-1 in combination with the EGFR tyrosine kinase inhibitor erlotinib may be an attractive therapeutic target in pancreatic cancer.
Abundance tracking by long-read nanopore sequencing of complex microbial communities in samples from 20 different biogas/wastewater plants
Authors: Brandt Christian , Bongcam-Rudloff Erik , Müller Bettina 
Published: November 2019

Abstract
Anaerobic digestion (AD) has long been critical technology for green energy, but the majority of the microorganisms involved are unknown and not cultivable, which makes abundance tracking difficult. Developments in nanopore sequencing make it a promising approach for monitoring microbial communities via metagenomic sequencing. For reliable monitoring of AD via long reads, a robust protocol for obtaining less fragmented, high-quality DNA, while preserving bacterial composition, was established. Samples from 20 different biogas/waste-water reactors were investigated and a median of 20 Gb sequencing data per flow cell were retrieved for each reactor. Using the GTDB index allowed sufficient characterisation of abundance of bacteria and archaea in biogas reactors. A dramatic improvement (1.8- to 13-fold increase) in taxonomic classification was achieved using the GTDB-based index compared with the RefSeq index. Ongoing efforts in GTDB to achieve more phylogenetically coherent taxonomic species definitions, including meta-assembled genomes, give a clear advantage over conventional classification databases such as RefSeq. Unlike conventional 16S rRNA studies, metagenomic read classification allows abundance of the unknown microbial fraction to be monitored.
From the edges of borders: reflections on water diplomacy in South Asia
Authors: Bisht Medha 
Published: November 2019

Abstract
This paper examines the pitfalls of macro-narrative on water diplomacy in South Asia which remains hostage to a strategic-geo-political construct. Building on critical approaches to water diplomacy, it presents the concept of ‘water communities’, which inhabit the borderlands of South Asia. Such an approach is not only useful in rooting water diplomacy in the concept of water communities but can also add a layered scalar understanding to water diplomacy through a ‘water plus’ approach. Apart from documented stories on cooperation, personal interviews 1 were conducted for highlighting the micro-narratives from the Himalayan borderlands of Bhutan, India and Nepal.
A Qualitative Analysis Based on Relative Expression Orderings Identifies Transcriptional Subgroups for Alzheimer’s Disease
Authors: Hong Guini , Zeng Pengming , Li Na , Cai Hao , Guo You , Li Xiaopeng , Li Keshen , Li Hongdong 
Published: November 2019

Background:Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease. However, few studies have investigated the heterogeneous gene expression patterns in AD.Objective and Methods:We examined the gene expression patterns in four brain regions of AD based on the within-sample relative expression orderings (REOs). Gene pairs with significantly reversed REOs in AD samples compared to non-AD controls were identified for each brain region using Fisher’s exact test, and filtered according to their transcriptional differences between AD samples. Subgroups of AD were classified by cluster analysis.Results:REO-based gene expression profiling analyses revealed that transcriptional differences, as well as distinct disease subsets, existed within AD patients. For each brain region, two main subgroups were classified: one subgroup reported differentially expressed genes overlapped with the age-related genes, and the other might relate to neuroinflammation.Conclusion:AD transcriptional subgroups might help understand the underlying pathogenesis of AD, and lend support to a personalized approach to AD management.
A Facile, Efficient and Solvent-Free Titanium (IV) Ethoxide Catalysed Knoevenagel Condensation of Aldehydes and Active Methylenes
Authors: Ramaiah Manjunatha M. , Shivananju Nanjunda Swamy , Shubha Priya Babu 
Published: November 2019

:
Titanium ethoxide has been employed as a novel and efficient reagent for the Knoevenagel
condensation of aldehydes with active methylenes such as diethyl malonate and ethyl cyanoacetate under
solvent free conditions to afford substituted olefins in high to excellent yields. The reaction is suitable
for a variety of aromatic, aliphatic and heteroaromatic aldehydes with various active methylenes.
Parallel to this, microwave irradiation has been utilized to achieve improved reaction rates and enhanced
yields. Herein, we illustrated a convenient method for the preparation of α,β-unsaturated compounds
using both conventional and microwave irradiation methods. An efficient and solvent free
Knoevenagel condensation between aldehydes and active methylenes was developed using titanium
ethoxide. The procedure proved to be successful with a wide range of substrates such as aromatic, aliphatic
and heterocyclic aldehydes and various active methylenes to afford substituted olefins. The reaction
was also carried out under microwave irradiation to accomplish the corresponding olefins with
improved reaction rates, yields and cleaner reaction profiles.We have developed an efficient and novel
methodology for the synthesis of olefinic compounds by Knoevenagel condensation under solvent-free
conditions using titanium ethoxide, for the first time, as a reagent as well as a solvent. This method is
appropriate for the synthesis of a variety of aromatic aldehydes containing various electron-donating
and withdrawing groups, aliphatic and heteroaromatic aldehydes. The significant advantages offered by
this methodology could be applied to various active methylenes in order to offer the corresponding
Knoevenagel products. Thus, we believe that this method delivers high conversions, cleaner reaction
profiles under solvent-free reaction conditions and shorter reaction times, all of which make it a very
useful and attractive approach for the preparation of a wide range of substituted olefins.
Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine
Authors: Hu Yiding , Xiao Yi , Rao Zhesui , Kumar Vasant , Liu Hanlan , Lu Chuang 
Published: November 2019

Background:
Carbon-carbon bond cleavage of a saturated aliphatic moiety is rarely seen in
xenobiotic metabolism. Olanexidine (Olanedine®), containing an n-octyl (C8) side chain, was mainly
metabolized to various shortened side chain (C4to C6) acid-containing metabolites in vivo in preclinical
species. In liver microsomes and S9, the major metabolites of olanexidine were from multi-oxidation
on its n-octyl (C8) side chain. However, the carbon-carbon bond cleavage mechanism of n-octyl (C8)
side chain, and enzyme(s) responsible for its metabolism in human remained unknown.

Methods:
A pair of regioisomers of α-ketol-containing C8side chain olanexidine analogs (3,2-ketol
olanexidine and 2,3-ketol olanexidine) were synthesized, followed by incubation in human liver microsomes,
recombinant human cytochrome P450 enzymes or human hepatocytes, and subsequent metabolite
identification using LC/UV/MS.

Results:
Multiple shortened side chain (C4to C6) metabolites were identified, including C4, C5and C6-
acid and C6-hydroxyl metabolites. Among 19 cytochrome P450 enzymes tested, CYP2D6, CYP3A4
and CYP3A5 were identified to catalyze carbon-carbon bond cleavage.

Conclusions:
3,2-ketol olanexidine and 2,3-ketol olanexidine were confirmed as the key intermediates in
carbon-carbon bond cleavage. Its mechanism is proposed that a nucleophilic addition of iron-peroxo species,
generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage
between the adjacent hydroxyl and ketone groups. As results, 2,3-ketol olanexidine formed a C6side
chain acid metabolite. While, 3,2-ketol olanexidine formed a C6side chain aldehyde intermediate, which
was either oxidized to a C6side chain acid metabolite or reduced to a C6side chain hydroxyl metabolite.
ARM-based Behavior Tracking and Identification System for Grouphoused Pigs
Authors: Liu Xingqiao , Xuan Jun , Hussain Fida , Chong Chen , Li Pengyu 
Published: November 2019

Background:
A smart monitoring system is essential to improve the quality of pig farming.
A real-time monitoring system provides growth, health and food information of pigs while the
manual monitoring method is inefficient and produces stress on pigs, and the direct contact between
human and pig body increases diseases.

Methods:
In this paper, an ARM-based embedded platform and image recognition algorithms are
proposed to monitor the abnormality of pigs. The proposed approach provides complete information
on in-house pigs throughout the day such as eating, drinking, and excretion behaviors. The
system records in detail each pig's time to eat and drink, and the amount of food and water intake.

Results:
The experimental results show that the accuracy of the proposed method is about 85%,
and the effect of the technique has a significant advantage over traditional behavior detection
methods.

Conclusion:
Therefore, the ARM-based behavior recognition algorithm has certain reference significance
for the fine group aquaculture industry. The proposed approach can be used for a central
monitoring system.
Pharmacological Activities Of Phala-Varga (Medicinal Fruits) – An Ayurvedic Review
Authors: Rabb Umakant N. 
Published: November 2019

Ayurveda is not only a science of life but also a spiritual science. This branch of science deals with the proper life style and dietary advice by Ayurveda scholars. Among them vegetables and fruits are used to eradicate the diseases and helps to maintain the health of the person. Since Vedic period the fruits are used as Prasadam as well as in the form of Bhoga (Offering food), Upavasa (Fasting) purposes. The fruits are not only cure the diseases but also helps the mind in relaxed state. As per Ayurveda the fruits are classified on the basis of Rasa (Taste). For example sour fruit, sweet fruit, bitter fruit etc. The fruits are man source for fibers, multivitamins and minerals, which helps to repair the damaged cells. Here an attempt is made to bring the scattered information of various types of fruits from the classical sources and their pharmacological action on the body, are dealt elaborately. Further scope of the study is to cultivate such fruits in the classical manner and make available seasonally to the market in an affordable price.