bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood cancer incidence and survival trends in Estonia (1970–2016): a nationwide population-based study
Authors: Paapsi Keiu , Baburin Aleksei , Mikkel Sirje , Mägi Margit , Saks Kadri , Innos Kaire 
Published: January 2020

Abstract
Background: Childhood cancers represent a small proportion of all cancers but are still a major public health problem. The study analysed long-term trends in childhood cancer incidence and survival in Estonia in relation to societal and health care transition. Methods: Data on all malignant tumours, diagnosed in children aged 0–14 during 1970–2016, were derived from the Estonian Cancer Registry. Age-standardised (World standard) incidence rates were calculated by ICCC-3 site groups and joinpoint regression was used to estimate annual percentage change (APC) for incidence trends. Cohort and period approach were used to estimate 5-year survival. Internal age standardisation was applied. Results: A total of 1628 incident cancer cases were diagnosed during the study period and overall incidence increased significantly at a rate of 0.5% per year. Significant increases were seen for neuroblastoma and germ cell tumours, for lymphoid leukemias and some CNS sub-sites. At the same time, decline in incidence was seen in almost all subgroups of unspecified neoplasms. The overall 5-year survival improved from 24% in 1970–1979 to 73% in 2010–2016, with the largest changes occurring in the 1990s and 2000s. For many sites, survival increase thereafter has been marginal. Conclusion: In this first comprehensive population-based study of childhood cancer incidence and survival in Estonia, long-term trends are shown in the context of societal and health care changes. Even though the increasing incidence of some sites may, at least partially, be explained by improved diagnostics reflected in the decreased incidence of unspecified neoplasms, the overall cancer incidence in children seems to be rising. Rapid progress in diagnosis and care have improved childhood cancer survival immensely, but deficit in Estonia persists compared to other European countries. Results of the study accentuate the need for a more in-depth analysis of clinical data, but also for the prioritization of childhood cancer in Estonia, to ensure access to standard care and innovative treatments.
Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016
Authors: Tamási Lilla , Horvath Krisztian , Kiss Zoltan , Bogos Krisztina , Ostoros Gyula , Müller Veronika , Urbán László , Bittner Nóra , Sárosi Veronika , Vastag Aladár , Polányi Zoltán , Nagy-Erdei Zsófia , Dániel Andrea , Nagy Balázs , Rokszin György , Abonyi-Tóth Zsolt , Moldvay Judit , Vokó Zoltán , Gálffy Gabriella 
Published: January 2020

Abstract
Background: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between 1th January 2011 and 31th December 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any anti-cancer treatment different from lung cancer protocols were excluded. Results: Lung cancer incidence and mortality increases with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46 to 3.01 (p<0.0001) among the 70–79 age group. We found 2-11% decrease in male incidence rate at most age groups, while a significant 1-3% increase was observed in older females (>60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary is decreasing in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.
Simultaneous palmar divergent dislocation of scaphoid and lunate concurrent with i psilateral humeroradial joint dislocation and humerus shaft fracture: report a rare case and add a new subtype
Authors: Feng Wan-wen , Xia Ya-yi , Liu Yue-peng , liu yuping 
Published: January 2020

Abstract
Background: Simultaneous palmar dislocation of scaphoid and lunate is a rare condition generally resulting from high-energy trauma and usually classified into two types. The literature has only reported nine patients with palmar divergent dislocation of scaphoid and lunate. Here we we present a case of accompanied ipsilateral humeroradial joint dislocation and open humeral shaft fracture caused by the same violence travelling from the wrist. Considering the emerging cases with their own characteristics, we suggest this severer injury be expanded into the third type of palmar dislocation of scaphoid and lunate.
Case presentation: A 31-year-old male who fell from a three-storey building, with his right wrist directly hitting the ground, was admitted to the orthopaedic department of our hospital. Physical and radiographic examinations defined simultaneous palmar divergent dislocations of scaphoid and lunate concurrent with ipsilateral humeroradial joint dislocation and open humeral shaft fracture. After debridement and internal fixation for humerus and close reduction for humeroradial joint, the scaphoid and lunate were treated with open reduction and fixation by Kirschner’s wires, and the palmar scapholunate ligament and anterior capsule were repaired through volar approach. After a 3-year follow-up, his humeral fracture healed without recurrent dislocations, collapse or avascular necrosis of scapholunate. Favorable hand function regained .
Conclusions: Palmar divergent dislocation of scaphoid and lunate caused by considerable violence is rare and appropriate to urgent open reduction and fixation with Kirschner’s wires and repair of the stronger palmar scapholunate ligament through single volar approach. When the residual violence continues to transmit to the upper extremity, ipsilateral dislocation or fracture may occur. We advise that this complex injury be classified into a third subtype of simultaneous palmar dislocation of scaphoid and lunate to avoid misdiagnosis.
Global atrial longitudinal strain is a powerful predictor of atrial fibrillation ablation outcomes in patients with normal echocardiographic images.
Authors: Pilichowska-Paszkiet Ewa , Baran Jakub , Kulakowski Piotr , Zaborska Beata 
Published: January 2020

Abstract
Background: Speckle tracking echocardiography (STE) with recent standardized left atrial (LA) deformation allows for the assessment of various LA function parameters. Proper qualification for catheter ablation (CA) for atrial fibrillation (AF) is still an issue. We aimed to assess the value of detailed evaluations of LA function parameters in patients without abnormal baseline standard echocardiography to predict the outcomes after CA for AF.Methods: We studied 84 patients (59% males, mean age 57.3±9.4 years) with nonvalvular paroxysmal AF who underwent CA and had normal preprocedural echocardiographic examinations. Peak longitudinal LA strain (LAS) and strain rate (LASR) during the reservoir (r), conduit (cd) and contraction (ct) phases were measured by STE. AF recurrence was confirmed by serial 4-7 day Holter ECG monitoring during a 12-month follow-up period. Three definitions of ablation success were used: complete success – freedom from symptomatic and asymptomatic AF without antiarrhythmic drug therapy (AA), success on AA – freedom from any AF with continued AA and partial success – clinically relevant reduction of the symptoms. The remaining patients were classified as having ablation failure.Results: Complete success was achieved in 37 (45.1%) patients, success on AA in 7 (8.5%) patients, and partial success in 11 (13.4%) patients. Altogether, 55 (67.1%) patients benefited from CA. The remaining 27 (32.9%) patients were classified as having CA failure. In the multivariate logistic regression analysis, only global LASr was identified as an independent predictor of AF recurrence after CA (OR [95% CI]: 1.27 [1.136-1.423], p<0.0001). The receiver operating characteristic analysis identified LASr as a powerful parameter for predicting the outcome after CA with an area under the curve (AUC) of 0.8548. When CA success was defined as all patients who benefited from CA, the multivariate logistic regression analysis also showed that only global LASr was an independent predictor of whether patients would benefit from CA (OR [95% CI]: 1.44 [1.207-1.716], p<0.0001)Conclusions: In patients with paroxysmal AF and normal standard echocardiographic assessments, LA strain analysis is crucial for selecting the best candidates for catheter ablation. LA reservoir strain is the only echocardiographic parameter that is an independent predictor of either complete success or clinical benefits from catheter ablation.
The Effect of Probe Geometry on Rind Puncture Resistance Testing of Maize Stalks
Authors: Cook Douglas D. , Meehan Kyler , Asatiani Levan , Robertson Daniel J 
Published: January 2020

Abstract
Background: Stalk lodging (breaking of plant stems prior to harvest) is a major impediment to increasing agricultural yields of grain crops. Rind puncture resistance is commonly used to predict the lodging resistance of several crop species. However, there exist no standard operating procedures or suggested protocols for conducting rind penetration experiments. In addition, experimental details of rind penetration tests such as the shape and size of the penetrating probe are rarely reported in the literature. This has prevented meta-analysis of results and has likewise prevented key findings of past studies from being replicated. As a first step towards establishing an agreed upon measurement standard for rind puncture resistance this study investigates the effect of the puncturing probe’s geometry on test results.Results: Results demonstrate that probe geometry has a significant impact on test results. In particular, results showed that a 2mm diameter chamfered probe produced stronger correlations with stalk bending strength than a 1.5mm diameter pointed probe. The chamfered probe was also more strongly correlated with geometric features of the stalk that are known to influence stalk lodging resistance (e.g., rind thickness, diameter and section modulus). In addition, several alternative rind penetration metrics were investigated, and some were found to be superior to the most common rind penetration metric of maximum load. Conclusions:There is a need in the agricultural and plant science community to create agreed-upon operating procedures and testing standards related to mechanical traits of plant stems. In particular, a standardized probe geometry and insertion rate for rind penetration studies are needed to enable greater interoperability and meta-analysis of results. Probe shape and size should be reported in any study conducting rind penetration tests as these factors significantly impact test results.
Transplantation of neural stem cells encapsulated in hydrogels improve functional recovery in a cauda equina lesion model
Authors: Fu Zhiyi , Wang Huidong , Wu Yujie , Zhu Tong 
Published: January 2020

Abstract
Background This study explored the therapeutic effects of transplantation of neural stem cells (NSCs) encapsulated in hydrogels in a cauda equina lesion model.Methods NSCs were isolated from neonatal dorsal root ganglion (DRG) and cultured in three-dimensional porous hydrogel scaffolds. Immunohistochemistry, transmission electron microscopy, Luxol fast blue staining, TUNEL assay were performed to detect the differentiation capability, ultrastructural and pathological changes, and apoptosis of NSCs. Furthermore, the functional recovery of sensorimotor reflexes was determined using the tail-flick test.Results NSCs derived from DRG were able to proliferate to form neurospheres and mainly differentiate into oligodendrocytes in the three-dimensional hydrogel culture system. After transplantation of NSCs encapsulated in hydrogels, NSCs differentiated into oligodendrocytes, neurons or astrocytes in vivo . Moreover, NSCs engrafted on the hydrogels decreased apoptosis and alleviated the ultrastructural and pathological changes of injured cauda equina. Behavioral analysis showed that transplanted hydrogel-encapsulated NSCs decreased the tail-flick latency and showed a neuroprotective role on injured cauda equina.Conclusions Our results indicate transplantation of hydrogel-encapsulated NSCs promotes stem cell differentiation into oligodendrocytes, neurons or astrocytes and contributes to the functional recovery of injured cauda equina, suggesting that NSCs encapsulated in hydrogels may be applied for the treatment of cauda equina injury.
The effect of proprioception training on knee kinematics after anterior cruciate ligament reconstruction
Authors: Jiang Lisi , Wang Yongjian , Huang Wenhan 
Published: January 2020

Abstract
Background Proprioception is essential for the normal movement of joint knees. The degree of functional recovery after ACL reconstruction is related with the degree of postoperative recovery of proprioception. The current study aimed to investigate the effect of proprioception training on functional level of activity and knee kinematics after anterior cruciate ligament reconstruction. Methods Forty patients who underwent ACL reconstruction between January 2017 and June 2019 were included. The patients were divided into proprioception group (n=20) and control group (n=20). All the patients followed common postoperative rehabilitation program. The proprioception group were given proprioception enhancement program besides common postoperative rehabilitation program. All the patients were assessed preoperatively, 6 months and 1 year after operation. The lymsolm scores, hop distances, and knee kinematics during unanticipated jump–cut maneuver were compared at different follow-up time points. Results There were no significant differences preoperative and postoperative Lysholm scores between two groups. After surgery, the proprioception group showed significantly higher hop distance (133.9 ± 26.2 cm) when compared with the control group (81.2 ± 17.2 cm, P=0.026) in 6-months and one-year follow-up (153.1 ± 19.3 vs 105.8 ± 20.7cm, P=0.034). For knee joint kinematics, the proprioception training group showed reduced knee abduction (valgus) angles and external rotations, and increased knee flexion when compared with the common training group. Conclusions We conclude that proprioceptive rehabilitation training enhance the kinematic performance and single leg hop distance in ACL-reconstructed populations during jump-stop, unanticipated cut maneuver. The findings will be scientific evidences to help clinicians and physiotherapists to evaluate the patients’ readiness for exercises and sports, especially in the cases of loading and extreme rotation conditions. Trial registration This study was retrospectively registered on Clnicaltrails.gov on 24 December.
Multilevel Anterior Cervical Corpectomy and Fusion for Ossification of the Posterior Longitudinal Ligament
Authors: Zhang Zhichao , Chen Jingxuan , Huang Wenmao , Zhao Yin , Sun Yanqing , Zhou Shengyuan , Chen Xiongsheng , Jia Lianshun 
Published: January 2020

Abstract
Background Cervical ossification of the posterior longitudinal ligament (OPLL) is a kind of spinal disorder widely spared in Asia. In dealing with multilevel cervical OPLL, the ideal surgical approach is still under debate. Here we introduce our findings of multilevel anterior cervical corpectomy and fusion (ACCF) in treating multilevel cervical OPLLMethods 79 patients with multilevel cervical OPLL who had ACOR on C4-C5 or C5-C6 were retrospectively reviewed. Patients’ Japanese Orthopedic Association (JOA) Score, the improvement rate of JOA Scores (RIS), sagittal cervical mobility (SCM) and the distance between the lower endplate of the vertebra body above the titanium mesh and the superior endplate of the vertebra body below the titanium mesh ( L ) were analyzed and subjected into paired-t test. Radiographic features and complications were described as well.Results p<0.001 in all paired-t tests of JOA Scores, SCM and L at 1day, 6months, 1year and 2year follow-ups compared with preoperative ones. Patients’ RIS continued to increase in 2 years. 6 (7.59%) patients’ L at the 2 years follow-up shortened more than 10mm than their postoperative L. 1 (1.27%) patient had severe titanium mesh canting.Conclusions Multilevel ACCF procedure has positive outcomes in treating multilevel cervical OPLL. Postoperative complications like titanium subsidence and dislocation can happen after this procedure. Follow-ups should be conducted regularly and thoroughly with this kind of patients.
Maintenance considerations in elderly dependent patients with implants
Authors: Sato Yuji , Koyama Shigeto , Ohkubo Chikahiro , Ogura Shin , Kamijo Ryutaro , Sato Soh , Aida Jun , Izumi Yuichi , Atsum Mihoko , Isobe Akio , Baba Shunsuke , Ikum Noriharu , Watanabe Fumihiko 
Published: January 2020

Abstract
Background Self-care and professional care of implants may prove difficult for elderly people who require nursing care. However, the actual state of care and problems remains unknown. In this study, we investigated the actual state of implant problems in elderly people living in their own home or in a nursing home who received visiting dental treatment due to their inability to visit a dental clinic.MethodsWe mailed questionnaire survey forms to 2339 representatives or specialists who were members of the Japanese Society of Oral Implantology, the Japanese Society of Gerodontology or the Japan Prosthodontic Society. We narrowed down the respondents to those who provided visiting dental treatment, and analyzed the actual state of implants observed during visiting dental treatment (type, care, problems, countermeasures, etc.).ResultsOf the 924 dentists who responded to the questionnaire survey, 291 (22%) provided visiting dental treatment. While the majority of implant types encountered in the previous 12 months were root-form implants, there were still a certain number of blade and subperiosteal implants. Daily implant care involved mostly cleaning with a toothbrush + auxiliary tools (such as interdental brushes). The most frequent implant problems encountered in the past were difficulty in cleaning and peri-implantitis. Medication and antiphlogistic treatment were most frequently adopted as countermeasures to implant problems, followed by observation. When we classified the results into those for the dentists who provided implant treatment and those for the dentists who did not, we found that many of the dentists who did not provide implant treatment opted for observation or medication, while those who provided implant treatment also implemented removal of the upper structure, retightening of screws, repair and so forth.Conclusions Since this survey was a questionnaire survey, future field surveys are necessary, it may be necessary for dentists who provide visiting dental treatment to acquire knowledge and skills for implant treatment or coordinate closely with experts.
Effects of no-till and rice varieties on nitrogen and phosphorus balance in rice fields
Authors: Yang Jiao , LIANG XINQIANG , Li Hua , Chen Yanfeng , Tian Guangming 
Published: January 2020

Abstract
Background: Nutrient balance in rice paddy fields can change under different tillage management practices; however, the extent of the change may differ for various rice varieties. A field experiment was conducted over 2 successive years from June 2016 to June 2018 to clarify the effects of different tillage methods and rice varieties on nutrients remaining in the surface soil and those taken up by the rice. There were four tillage/rice variety treatments: no-till/japonica rice (NTJ), no-till/glutinous rice (NTG), conventional tillage/japonica rice (CTJ), and conventional tillage/glutinous rice (CTG) with three replicates of each.Results: The tillage method and rice variety had interactive effects on the surface balance of nitrogen (N) and phosphorus (P). After the 2-year experiment, total N and P pools in the 20 cm surface soil layer were highest under the NTJ treatment (4757.0 kg N ha-1, 2428.5 kg P ha-1) and lowest under the CTG treatments (4726.3 kg N ha-1, 2412.0 kg P ha-1). Under no-till conditions, japonica rice had higher grain yield but lower straw biomass than that of glutinous rice. NTG treatment significantly increased the N and P content in rice grains and straw. The environmental losses of N and P in the rice fields mainly occurred during the rice season. Based on nutrient balance estimation, N losses in the NTJ, NTG, and CTJ treatments were reduced by 15.03 kg N ha-1, 11.55 kg N ha-1, 6.72 kg N ha-1, respectively, as compared with that of the CTG treatment. The corresponding P losses were reduced by 8.02 kg P ha-1, 7.84 kg P ha-1, and 3.96 kg P ha-1. In terms of economic benefits, NTJ also resulted in the highest actual income (18896.5 yuan ha-1) and the highest ratio of production to investment (6.40).Conclusion: No-till was more likely to maintain soil N and P nutrients than conventional tillage, and this advantage was most significant when planting japonica rice. In addition, no-till was conducive to N and P uptake by rice, but only japonica rice exhibited increased grain yield. Consequently, the NTJ treatment was recommended.