bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring factors of diagnostic delay for patients with bipolar disorder: A population-based cohort study
Authors: Lublóy Ágnes , Lilla Keresztúri Judit , Németh Attila , Mihalicza Péter 
Published: November 2019

Abstract
Background Bipolar disorder if untreated, has severe consequences: widespread role impairment, higher health care costs, mortality and morbidity. Although effective treatment is available, the delay in diagnosis might be as long as 10-15 years. In this study we aim at documenting the length of the diagnostic delay in Hungary and identifying factors associated with it.Methods Kaplan-Meier survival analysis and Cox proportional hazards model was employed to examine factors associated with the time to diagnosis of bipolar disorder measured from the date of the first presentation to any specialist mental healthcare institution. We investigated three types of factors associated with delays to diagnosis: demographic characteristics, clinical predictors and patient pathways. Administrative data was retrieved from specialist care; the population-based cohort includes 8,935 patients from Hungary.Results In the sample, diagnostic delay was 6.46 years on average. The mean age of patients at the time of the first bipolar diagnosis was 43.59 years. 11.85% of patients were diagnosed with bipolar disorder without any delay, and slightly more than one third of the patients (35.10%) were never hospitalized with mental health problems. 88.80% of the patients contacted psychiatric care for the first time in outpatient settings, while 11% in inpatient care. Diagnostic delay was shorter, if patients were diagnosed with bipolar disorder by non-specialist mental health professionals before. In contrast, diagnoses of many psychiatric disorders received after the first contact were coupled with delayed bipolar diagnosis. We found empirical evidence that in both outpatient and inpatient care prior diagnoses of schizophrenia, unipolar depression without psychotic symptoms, and several disorders of adult personality were associated with increased diagnostic delay. Patient pathways played an important role as well: the hazard of delayed diagnosis increased if patients consulted mental healthcare specialists in outpatient care first or they were hospitalized.Conclusions We systematically described and analysed the diagnosis of bipolar patients in Hungary controlling for possible confounders. Our focus was more on clinical variables as opposed to factors controllable by policy-makers. To formulate policy-relevant recommendations, a more detailed analysis of care pathways and continuity is needed.
Non-interventional retrospective study to evaluate menstrual bleeding profiles, tolerability and quality of life of women using the new vaginal ring Ornibel® delivering etonogestrel 0.120 mg and ethinylestradiol (EE) 0.015 mg per day
Authors: REGIDOR PEDRO ANTONIO , Sailer Manuela , Colli Enrico , Calvo Enrique , Palacios Santiago , Roemer Thomas 
Published: November 2019

Abstract
Background: To assess the menstrual cycle profile, tolerability, quality of life and sexual wellbeing in women using the vaginal contraceptive ring Ornibel®. Method: Non-interventional, retrospective, multi-center study on 103 women between 18 and 45 years old that used Ornibel® for at least 6 months. Menstrual cycle characteristics, vaginal infections and quality of life parameters were analyzed. Change in menstrual bleeding profiles and menstrual bleeding associated pain were assessed via visual analogue scales (VAS). Results: Menstrual flow and dysmenorrhea reduced significantly. The VAS score reductions were 16 and 22,5 points respectively (p < 0.001). No differences were observed between women that changed from another contraceptive method to the vaginal ring. The percentage of women without unscheduled bleedings or spotting increased from 79% to 88%. The percentage of women with unscheduled bleeding or spotting significantly decreased from 21% to 12%. Women rated the ring as very comfortable or comfortable (97%) as well as easy to insert (91%). The continuation of the usage of the ring and a recommendation for the ring were significantly associated with these two parameters. Conclusions: Ornibel® improved the menstrual cycle profile, reduced dysmenorrhea and shows a very high adherence to the use. Clinical trial register: DRKS-ID: DRKS00014982
MicroRNA-99a promotes cell proliferation, migration and invasion in gastric cancer by modulating c-Src
Authors: Pan Yue , Chen Weixing , Yuan Xin , Lu Hongpeng , Xu Lei , Li Peifei 
Published: November 2019

Abstract
Background: Recent studies have shown that microRNA-99a(miR-99a)plays a key role in the development of virious malignancies; however, its relationship with gastric cancer remains unclear. In this study, we investigated the functions and potential mechanisms of miR-99a in gastric cancer. Methods: Real-time qRT-PCR was used to assess the expression levels of miR-99a in gastric cancer tissue samples and cell lines compared to their matched adjacent normal tissues and a normal gastric mucosa epithelial cell line, respectively. SGC-7901 cells were transfected with miR-99a mimics and negative controls to determine the effects of miR-99a overexpression on cell proliferation, cell cycle transition, migration and invasion of gastric cancer cells in vitro . The role of miR-99a in endogenous c-Src expression in gastric cancer cells was also investigated by qRT-PCR and Western blotting. Results: Our results showed a significant increase in miR-99a expression in both gastric cancer tissues and cells compared to normal tissues and cells. Overexpression of miR-99a significantly promoted the cell proliferation, migration and invasion of gastric cancer cells compared to normal cells, with a concurrent increase in the S+G2 phases of the cell cycle. Further investigations found that miR-99a overexpression led to significant upregulation of endogenous c-Src. Conclusion: Taken together, our findings suggest that miR-99a may act as a tumour promoter in the pathogenesis of gastric cancer by indirectly modulating c-Src expression.
Tuberculosis treatment results in Western Iran over the past 13 years
Authors: Soofi Moslem , moradi atefeh , Riyahi Parisa , Rezaei Sholeh , Shakiba Ebrahim , Moradinazar Mehdi 
Published: November 2019

Abstract
Introduction Tuberculosis is one of Iran's most significant infectious diseases, which with the advent of new and chronic diseases, is still known as the most threatening disease of human community. The goal of this research was to assess the result of TB treatment in western Iran (province of Kermanshah) and its associated factors during 2005 to 2017.Method In this cross-sectional study, all patients who had tuberculosis from 2005 to the end of 2017 were evaluated. Treatment outcomes were categorized into four domains of “treatment completion," “death," “treatment failure," and “recoveries" based on national guidelines, and factors affecting outcome were identified using univariate and multivariate logistic regression.Results Tuberculosis incidence was 15.21 in males and 14.32 in females per 100,000 individuals. The therapy result was almost uniform during the years investigated. 32.2% had extra pulmonary TB; 58.7% completed treatment; 9.9% died, and 4.1% had treatment failure. After controlling for key factors, the odds of completion of therapy in females were 1.1 (1.0-1.3) times greater than in males, and therapy failure and mortality caused by tuberculosis were also smaller in females than in males 0.6(0.4-0.8) and 0.5(0.3-0.7) respectively). HIV was the greatest variable in the prevalence of tuberculosis with 9.5 (5.8–16.8) times greater chances of death in HIV-positive people than those without HIV.Conclusion Given the high prevalence of pulmonary tuberculosis and public health concerns, early screening and infection diagnosis, education and protective measures are suggested to prevent tuberculosis patients.
Impact of invasive species on the density and body size of an insular endemic lizard (Trachylepis atlantica)
Authors: Gasparotto Vinícius Peron de Oliveira , Micheletti Tatiane , Mangini Paulo Rogério , Dias Ricardo Augusto 
Published: November 2019

Abstract
BackgroundInvasive species have been responsible for the extinction of several species around the world. The Noronha skink is an endemic lizard from the Fernando de Noronha archipelago, Brazil, that has been suffering from habitat changes and the introduction of invasive species. ResultsTwo methods were used to estimate the density of the Noronha skink. The density on the main island was 0.167 ± 0.090 individuals/m²; that on the secondary islands was 0.357 ± 0.170 individuals/m²; and that on the entire archipelago was 0.184 ± 0.109 individuals/m². Moreover, the morphometric parameters of the Noronha skink were compared between the main island and secondary islands. The values of all parameters were higher on the secondary islands. ConclusionThe occurrence of invasive species on the main island seems to be a determining factor in the density and body size of the Noronha skink.
Effect of container geometry on colloids removal from water in oscillation-based flocculation
Authors: Halfi Eran , Brenner Asher , Katoshevski David 
Published: November 2019

Abstract
Colloid removal in water treatment plants is commonly done by a sequence of processes that includes coagulation, flocculation, sedimentation, and filtration. The current study presents an innovative technique, termed grouping, for the removal of these suspended particles based on physical flow manipulation, which causes the particles to aggregate. Previous results showed that gentle oscillation in a cylindrical container facilitates simultaneous flocculation and sedimentation in the same reactor over shorter periods of time than are possible using the conventional treatment approach. This finding may confer marked improvements on the processes used today by enabling the use of both smaller reactors and less energy. Based on the findings with the cylindrical vessel, here the grouping technique is further examined in a rectangular container and over a range of different initial turbidities. The results indicate that the removal efficiency is higher in the rectangular container under the different initial turbidities tested. In addition, the removal efficiency was shown to remain robust with the decreases in initial turbidity and alum concentrations that occur during treatment. The positive results of our previous study taken together with this finding hint at the strong potential of the grouping technique to improve common flocculation processes.
Typy i funkcje refleksji w myśli tomistycznej
Authors: Sośnicka Joanna 
Published: November 2019

W nowożytności refleksja została utożsamiona z przedmiotem poznania filozoficznego. Epistemologia przejęła znaczny zakres badań metafizyki, przez co racjonalizm oddalał się od realizmu, a realizm od konkretnie istniejącego bytu. Odmienne teorie poznania i przedmiotu suponowały wewnętrznie spójne, choć różniące się systemy filozoficzne. Pojęcie refleksji nabrało swoistego znaczenia w filozofii i po dziś dzień odgrywa istotną rolę w rozumieniu przedmiotu poznania i poznającego podmiotu. Św. Tomasz z Akwinu używa rzeczowników reflexio oraz reditio. Znaczenie łacińskiego słowa reditio – „ruch powrotny” podkreśla naturalny dynamizm poznania ludzkiego. Ruch realizuje się w pełni w powrocie do swego źródła, zataczając koło, które zaczyna się w kontakcie podmiotu poznającego z przedmiotem, a kończy w ubogaconym doświadczeniem podmiocie. Refleksja jest tym ruchem, dzięki któremu człowiek poznaje, że poznaje, a w pełni poznaje, kiedy już poznał. Funkcje refleksji pozwala scharakteryzować podział na refleksję towarzyszącą reflexio in actu exercito oraz refleksję sygnitywną reflexio in actu signato. Wiąże ona więc świadomość w tożsamość „Ja”, czyli tożsamość ludzką, nadając jej koherentny, podmiotowy sens strukturalizujący się poprzez poznawanie zewnętrznie istniejących przedmiotów.
Controlled Release Gel Encompassing Curcumin Microspheres and Diclofenac Diethylamine for Feat Against Arthritis Inflammation
Authors: Singh Prabha , Dabre Shalan 
Published: November 2019

Background:
Diclofenac and curcumin is anticipated to have synergistic action. Hence,
topical route of administration can be used in minimizing the issues with oral administration of both
drugs.

Objective:
This research aims at formulation of controlled release dosage form containing curcumin
microspheres and diclofenac diethylamine and then incorporating it into gel formulation for treatment
of inflammation associated with rheumatoid arthritis.

Methods:
Curcumin microspheres were prepared, optimized and assayed. Gel containing microspheres
was formulated and evaluated for physicochemical parameters like spreadability and viscosity.
In vitro and ex vivo diffusion studies were carried out followed by evaluation of efficacy.
Efficacy of the developed formulation was evaluated for anti-inflammatory activity.

Results:
Particle size, Zeta potential, pH, spreadability and viscosity of optimized Batch F1 was
found to be in range 0.5 μm - 5 μm,-27.9 mV, 6.2, 105 g cm/s and 7500 cps respectively. In vitro
diffusion of developed gel of diclofenac diethylamine and curcumin was found to be 92.16 ±
0.0040 % in 3 h and 92.54 ± 0.0036 % in 12 h as compared to 79.57 ± 0.004 % diffusion in 2 h for
marketed gel, thus showing controlled delivery of curcumin.

Conclusion:
Decreased inflammation in formulation treated group by 72.53% and 50.75% in marketed
treated group was seen. Thus the formulation developed showed prolonged activity as well as
better anti-inflammatory activity.
The Impact of Variable Factors on the Health-Related Quality of Life in the Elderly in Japan and Russia
Authors: Kosilov Kirill , Amedzawa Hiroki , Kuzina Irina , Kuznetsov Vladimir , Kosilova Liliya 
Published: November 2019

Aim:
The study of the impact of socio-economic, demographic factors and polymorbidity
on the quality of life associated with health (HRQoL) in elderly people from Japan and Russia.

Background:
Factors affecting the quality of life of the elderly in both countries are poorly understood.

Objective:
Make a comparative analysis of factors affecting the quality of life of the elderly of both
sexes in Japan and Russia.

Methods:
The age range in this study is 65-95 years old. For the study of HRQoL, a questionnaire
Health Status Survey-Short Form 36v2 was used, including two main domains: physical and mental
health. The level of polymorbidity was studied using CIRS-G. The linear regression model of the
influence of variables upon HRQoL was calculated for SES, demographic characteristics, and morbidity.

Results:
Strong associations with HRQoL in the combined sample had a living together with relatives
(r=6.94 (5.17-8.72) p<0,05), the incidence rate (r=8.50 (5.51-11.49), p<0.01) and the older
age (r=5.39 (2.63-8.16), p<0,01.). The elderly inhabitants of Japan had a higher self-assessment for
physical health in the age ranges 65-74 and over 85 years old (p<0.05), and a higher selfassessment
of mental health at the age of 75-84 years old. Sixty-eight elderly Japanese and 48%
Russians estimated their physical health as normal.

Conclusion:
The effect of living together, morbidity and age upon HRQoL is manifested equally
strongly both among the inhabitants of Japan and among the Russians. The elderly Japanese estimate
the state of physical and mental health as a whole higher than their Russian peers.
Comparative Analysis on the Elastic Behavior of Composite Materials Based on Plant Fibers: Bamboo / Epoxy and Coconut / Epoxy
Authors: Mokaddem Allel , Doumi Bendouma , Belkheir Mohammed , Touimi Amina 
Published: November 2019

Background:The exploitation by the industries of vegetable fibers in the field of composite materials has made it possible to reduce the dependency of oil which is the result of their mechanical properties, their thermal resistance and biodegradability.Methods:In this work, we carried out a comparative study by a genetic simulation on two materials based on different natural reinforcements (Bamboo and Coconut) to see the influence of its fibers on the elastic behavior of bio-composite materials.Results:The results of our genetic simulation showed that Bamboo / Epoxy is more resistant than Coconut / Epoxy and that shear damage of Bamboo / Epoxy is lower than that of Coconut / Epoxy by 11 to 12.5%.Conclusion:The results are similar to the results given by Rao KMM where he showed by experimental tests that Bamboo fiber is the most resistant when compared with other fibers especially coconut fiber.
Assessing the Thermal Performance of Negeri Sembilan Traditional Malay House towards Sustainable Practice
Authors: Nik Hassin Nik Siti Fatimah , Misni Alamah 
Published: November 2019

Traditional Malay house has characteristics of the passive thermal design that naturally practices climatic design strategies. Currently, Urban Heat Island (UHI), causing an increase in energy consumption for cooling purposes, especially in the residential sectors. Consequently, modern building construction has a poor passive thermal design. This study aims to assess the thermal performance of Negeri Sembilan traditional Malay house towards sustainable practice in the tropical environment. The main finding shows that house openings allow natural cross-ventilation, while less strategic house orientation towards climate factors and lightweight materials used contributes to the uncomfortable of the interior spaces reaches as much as 35ºC during the peak time of the day. This study highlights ideas and knowledge in improving the construction technology for modern architecture to produce an effective indoor thermal performance in a tropical environment. Keywords: Malay House; Traditional Architecture; Thermal Performance; Tropical; EnvironmenteISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1914
Implementasi Guru Menggunakan Metode Permainan Pada Pelajaran IPA Di Sekolah Dasar
Authors: Chan Faizal 
Published: November 2019

Abstrak. Efektivitas guru adalah kemampuan guru dalam mengajar untuk mencapai tujuan yang ditetapkan. Efektivitas guru adalah keberhasilan pendidikan bagi siswa mereka, karena guru yang efektif dapat mendukung keberhasilan tingkat pembelajaran peserta didik. Studi ini bertujuan untuk mempengaruhi efektivitas guru dalam menggunakan metode permainan pada ilmu mata pelajaran kelas III SDN 110/1 Tenam Village. penelitian ini menggunakan metode kualitatif. Lokasi penelitian ini di SDN 110/1 Tenam Village, Kecamatan Muara Bulian, Kecamatan Batanghari yang digelar selama satu bulan. Alat pengumpulan data yang digunakan dalam penelitian ini dengan kajian pengamatan rencana pelaksanaan pembelajaran, guru meninjau dalam pelaksanaan pembelajaran, dan wawancara guru. Hasil penelitian menunjukkan keefektifan guru telah efektif dalam menggunakan metode permainan mata pelajaran IPA di kelas III SDN 110/1 desa Tenam. Dan pelaksanaan pelajaran IPA di kelas III SDN 110/1 desa Tenam belajar sesuai dengan tahapan metode permainan belajar.
Kata kunci : efektivitas guru, metode permainan, pelajaran sains.
MENINGKATKAN KECERDASAN LOGIKA MATEMATIKA ANAK MELALUI PERMAINAN KREATIF SEDOTAN DI KELAS A TK DAARUL FIQRI
Authors: Karyani Neni , Haryati Tuty 
Published: November 2019

tujuan yang ingin dicapai dari penelitian ini adalah akan mendapat informasi dan data-data tentang meningkatkan kecerdasan logika matematika di TK A Daarul Fiqri melalui permainan kreatif sedotan dengan menggunakan metode penelitian tindakan kelas (PTK) yang sering disebut Classroom Action Research (CAR). Penelitian ini merupakan bentuk penelitian yang bersifat reflektif dengan melakukan tindakan tertentu agar dapat memperbaiki meningkatkan praktik pembelajaran dikelas secara profesional. Teknik pengumpulan data yaitu dengan obsevasi, wawancara dan dokumentasi. Data anak yaitu 17 anak yang terdiri dari laki-laki 5 orang, perempuan 12 orang. Hasil dari penelitian ini adalah dengan menggunakan 2 siklus, dimana dari 2 siklus itu menunjukan bahwa kecerdasan logika matematika anak bisa meningkat melalui permainan kreatif sedotan. Analisis data diperoleh dari prasiklus dan pascasiklus.
MEDIA BONEKA TANGAN DAPAT MENINGKATKAN KETERAMPILAN MENYIMAK ANAK USIA 5-6 TAHUN DENGAN METODE BERCERITA
Authors: Wulandari Rizki , Nursyamsiyah Siti , Akhyadi Ade Sadikin , Jumiatin Dedah Jumiatin , Sumitra Agus 
Published: November 2019

One from of ability to tell stories is the listening process.in general, older brothers still have difficulty listening to and unerstanding the stories that the teacher conveyed, one of conditions is the influence of the teacher’s low creativity in determining the medium of learning to tell childeren. On the other hand children are still less focused and often talk to themselves with their friends so that children do not concentrate and listen to the explanation from the teacher, this happens to the child and during the learning process. This phenomenon is a problem that needs to be found as an alternative solution. One methode that can be used is the storrytelling methode using hand puppet media. This study used a classroom action research methode which numbered 12 children. The results obtained from 12 children are significant, no children are undeveloped, if the value is obtained, it is 0 percent, 1 child begins to develop, if the value is obtained, it is8%, 4 children have developed as expected or if the value is obtained, it is 32%, and 7 children develop very well or if the value is obtained, its is 60%. From the percentage accumulated there was an average increase of 33%. According to the results of improvement in each cycle, the use of hand puppet media on story telling techniques can influence the listening skills of group B children in this kindergarten. From tehe data obtained it can be concluded that the media of hand puppets can improve the listening skill of children.Keywords: Listening Skill, tell stories, Hand Puppet