bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of autistic and non-autistic women’s experience of motherhood
Authors: Pohl A. L. , Crockford S. K. , Blakemore M. , Allison C. , Baron-Cohen S. 
Published: January 2020

Abstract
Background
Autism is a lifelong neurodevelopmental difference and disability, yet there is limited research examining parenting in autistic mothers.

Objective
To explore autistic mothers’ experience of the perinatal period and parenthood. This includes pregnancy, childbirth, the postpartum period, self-perception of parenting strengths and weaknesses, communication with professionals in relation to one’s child, mental health difficulties and the social experience of motherhood. It also includes disclosing one’s diagnosis of autism in parenting contexts.

Methods
We used a community-based participatory research model, and recruited an advisory panel, with whom we co-developed an anonymous, online survey for autistic mothers. The online survey was completed by autistic and non-autistic mothers, and we compared their responses using Chi-squared analysis.

Sample
Autistic mothers (n = 355), and non-autistic mothers (n = 132), each of whom had at least one autistic child, were included in our final analysis.

Results
There were differences in education, gender identity and age of mother at birth of first child. Autistic mothers were more likely to have experienced additional psychiatric conditions, including pre- or post-partum depression, and reported greater difficulties in areas such as multi-tasking, coping with domestic responsibilities and creating social opportunities for their child. They were also more likely to report feeling misunderstood by professionals, and reported greater anxiety, higher rates of selective mutism, and not knowing which details were appropriate to share with professionals. They were also more likely to find motherhood an isolating experience, to worry about others judging their parenting, or feel unable to turn to others for support in parenting. However, despite these challenges, autistic mothers were able to act in the best interest of their child, putting their child’s needs first.

Conclusions
Autistic mothers face unique challenges and the stigma associated with autism may further exacerbate communication difficulties. Greater understanding and acceptance amongst individuals who interact with autistic mothers is needed, and autistic mothers would benefit from additional and better-tailored support.
Interactions of clinical relevance associated with concurrent administration of prescription drug and food or medicinal plants: a systematic review protocol
Authors: Orellana-Paucar Adriana , Vintimilla-Rojas Daniela 
Published: January 2020

Abstract
Background
An inadequate combination of prescription drugs with food or medicinal plants could cause adverse effects in patients or produce negative therapeutic results. Therefore, this generic systematic review protocol aims to identify and synthesize the literature on clinical characteristics and safety issues of these types of pharmacological interactions occurring in children, adolescents, adults, pregnant/lactating women, and older adults.

Methods/design
This generic protocol follows the stated guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement. A literature search will be performed in PubMed, Scopus, and Virtual Health Library (VHL) electronic databases from 1960 till present for studies reporting clinical characteristics and safety issues associated with pharmacological interactions occurring between prescription drugs and food or medicinal plants in participants from birth-age to ≥ 65-year-old, including pregnant/lactating women. Lateral searching will be carried out in PubMed via related citation. Two reviewers will carry out an independent evaluation of eligible studies as well as the corresponding data extraction of the selected ones. Subsequently, the methodological quality evaluation of the selected articles will be completed using the corresponding Joanna Briggs Institute Checklists. Moreover, the quality of evidence will be graded according to the criteria of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group. Quantitative research in humans comprising clinical trials and clinical, comparative and, observational studies will be included. The main outcomes of this protocol involve reported potential food-drug and herb-drug interactions, associated safety issues, and adverse reactions along with the generic name of the prescribed drug and the scientific name of the food and medicinal plants involved in these types of pharmacological interactions. Finally, findings extracted from the selected studies will be summarized in a narrative synthesis.

Discussion
This generic systematic review protocol seeks to synthesize and critically evaluate current knowledge besides to identify any comprehension gaps in the concurrent administration of prescription drugs with food and herbs. By achieving a better understanding of this topic, this information will allow healthcare professionals to develop useful strategies to recognize, manage, and prevent these types of pharmacological interactions at different age stages, including pregnant/lactating women.

Systematic review registration
PROSPERO CRD42018117308
Determinants of biogas technology adoption in southern Ethiopia
Authors: Shallo Lemma , Ayele Mitiku , Sime Getachew 
Published: January 2020

AbstractBackgroundRenewable energies such as biogas are considered as clean sources of energy that minimize environmental impacts and are sustainable with regard to current and future economic and social needs. Biogas offers an attractive option for replacing the unsustainable usage of traditional energy sources such as firewood, cow dung, and charcoal in developing countries. In Ethiopia, these energy sources have been in decline. To address these challenges, mainly in rural areas, biogas technology has been domesticated since 2009, as seen in the National Program. The purpose of this study is thus to examine factors that influence households' decisions of adopting biogas technology in rural areas in southern Ethiopia.MethodsA sample of 268 households with 134 biogas adopters and 134 non-adopters were surveyed using simple random and purposive sampling techniques, respectively. The data were collected through individual interviews of households using a semistructured questionnaire. Descriptive statistics and a binary logistic regression model were used for the data analysis. The binary logistic regression model was applied to identify determinant factors affecting the adoption of biogas technology.ResultsThe results of the study indicated that biogas adopter and non-adopter households had significant mean differences in education level, cattle size, household income, farmland size, number of planted trees as well as the distance to water sources, market places, and firewood sources. Level of education, level of income, access to credit, distance to firewood sources, and access to electronic media had a significantly positive influence on the adoption of biogas technology. Conversely, distance to water sources and access to electricity had a significantly negative influence on the adoption of biogas technology.ConclusionsBiogas technology mostly appears in privileged households having a better socioeconomic status and other resource endowments. The beneficiaries are thus households that can afford the higher initial investment costs for bio-digester installation, maintenance services and purchasing bio-digester spare parts; as well as households that have access to credit facilities, water sources for adequate water supply, markets for purchasing spare parts and electronic media for information, and also households residing far away from firewood sources.
Bipolar depression: a major unsolved challenge
Authors: Baldessarini Ross J. , Vázquez Gustavo H. , Tondo Leonardo 
Published: January 2020

AbstractDepression in bipolar disorder (BD) patients presents major clinical challenges. As the predominant psychopathology even in treated BD, depression is associated not only with excess morbidity, but also mortality from co-occurring general-medical disorders and high suicide risk. In BD, risks for medical disorders including diabetes or metabolic syndrome, and cardiovascular disorders, and associated mortality rates are several-times above those for the general population or with other psychiatric disorders. The SMR for suicide with BD reaches 20-times above general-population rates, and exceeds rates with other major psychiatric disorders. In BD, suicide is strongly associated with mixed (agitated-dysphoric) and depressive phases, time depressed, and hospitalization. Lithium may reduce suicide risk in BD; clozapine and ketamine require further testing. Treatment of bipolar depression is far less well investigated than unipolar depression, particularly for long-term prophylaxis. Short-term efficacy of antidepressants for bipolar depression remains controversial and they risk clinical worsening, especially in mixed states and with rapid-cycling. Evidence of efficacy of lithium and anticonvulsants for bipolar depression is very limited; lamotrigine has long-term benefit, but valproate and carbamazepine are inadequately tested and carry high teratogenic risks. Evidence is emerging of short-term efficacy of several modern antipsychotics (including cariprazine, lurasidone, olanzapine-fluoxetine, and quetiapine) for bipolar depression, including with mixed features, though they risk adverse metabolic and neurological effects.
Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study
Authors: Li Yuan , Deng Shiyong , Mei Li , Li Zhengzheng , Zhang Xinyun , Yang Chao , Li Yu 
Published: January 2020

Abstract
Background
Fixed appliances have been the mainstream for orthodontic treatment, while clear aligners, such as Invisalign system, have become increasingly popular. The prevalence of apical root resorption (ARR) in patients with clear aligners is still controversial. The aim of this study was to investigate and compare the prevalence and severity of ARR in patients treated with clear aligners and fixed appliances using cone beam computed tomography (CBCT).

Materials and methods
A total of 373 roots from 70 subjects, with similar baseline characteristics and the ABO discrepancy index scores (i.e., treatment difficulty), were included into two groups: the clear aligners group (Invisalign, Align Technology, California, USA) and fixed appliances group (Victory Series; 3 M Unitek, California, USA). Root length of each anterior tooth was measured on the CBCT images by two blinded investigators. The ARR on each tooth was calculated as the difference of root length before and after orthodontic treatment. Chi-square test and paired t test was used to compare the ARR between the two groups as well as before and after orthodontic treatments.

Results
Prevalence of ARR in the clear aligners group (56.30%) was significantly lower than that in the fixed appliances group (82.11%) (P < 0.001). The severity of ARR in the clear aligners group (0.13 ± 0.47 mm) was significantly less than that in the fixed appliances group (1.12 ± 1.34 mm) (P < 0.001). The most severe ARR was found on the maxillary canine (1.53 ± 1.92 mm) and lateral incisor (1.31 ± 1.33 mm) in the fixed appliances group; the least ARR was found on the mandibular canine (− 0.06 ± 0.47 mm) and lateral incisor (0.04 ± 0.48 mm) in the clear aligners group (P < 0.001).

Conclusions
The prevalence and severity of ARR measured on CBCT in patients with clear aligners were less than those in patients with fixed appliances.
Toward multi-label sentiment analysis: a transfer learning based approach
Authors: Tao Jie , Fang Xing 
Published: January 2020

AbstractSentiment analysis is recognized as one of the most important sub-areas in Natural Language Processing (NLP) research, where understanding implicit or explicit sentiments expressed in social media contents is valuable to customers, business owners, and other stakeholders. Researchers have recognized that the generic sentiments extracted from the textual contents are inadequate, thus, Aspect Based Sentiment Analysis (ABSA) was coined to capture aspect sentiments expressed toward specific review aspects. Existing ABSA methods not only treat the analytical problem as single-label classification that requires a fairly large amount of labelled data for model training purposes, but also underestimate the entity aspects that are independent of certain sentiments. In this study, we propose a transfer learning based approach tackling the aforementioned shortcomings of existing ABSA methods. Firstly, the proposed approach extends the ABSA methods with multi-label classification capabilities. Secondly, we propose an advanced sentiment analysis method, namely Aspect Enhanced Sentiment Analysis (AESA) to classify text into sentiment classes with consideration of the entity aspects. Thirdly, we extend two state-of-the-art transfer learning models as the analytical vehicles of multi-label ABSA and AESA tasks. We design an experiment that includes data from different domains to extensively evaluate the proposed approach. The empirical results undoubtedly exhibit that the proposed approach outperform all the baseline approaches.
Trends in alcohol and marijuana detected in homicide victims in 9 US states: 2004–2016
Authors: Nazarov Oybek , Li Guohua 
Published: January 2020

Abstract
Background
Use of alcohol and other drugs is a major risk factor for assaultive injuries and violent deaths. The purpose of this study was to examine the time trends in the prevalence of alcohol and marijuana detected in homicide victims.

Methods
We analyzed toxicological testing data for homicide victims (n = 12,638) from the 2004–2016 National Violent Death Reporting System in 9 US states (Colorado, Georgia, Massachusetts, New Jersey, Oregon, Rhode Island, South Carolina, Virginia, and Wisconsin). We used the Cochran-Armitage test for trend to assess the statistical significance of changes in the prevalence of alcohol and marijuana detected in these homicide victims during the study period.

Results
Overall, 37.5% of the homicide victims tested positive for alcohol, 31.0% positive for marijuana, and 11.4% positive for both substances. During the study period, the prevalence of marijuana increased from 22.3% (95% confidence interval [CI] = 19.6, 25.0) in 2004 to 42.1% (95% CI = 39.2, 44.9) in 2016 (Z = -15.7; P < .001) while the prevalence of alcohol declined slightly (Z = 1.5; P = 0.143). Marked increases in the prevalence of marijuana were observed in both sexes and across age and racial groups.

Conclusions
Marijuana is increasingly detected in homicide victims irrespective of demographic characteristics. Further research is needed to assess the causal role of marijuana use and concurrent use of marijuana and alcohol in homicide victimization.
Spontaneous pneumoperitoneum with duodenal diverticulosis in an elderly patient: a case report
Authors: Ueda Takeshi , Tanaka Tetsuya , Yokoyama Takashi , Sadamitsu Tomomi , Harada Suzuka , Yoshimura Atsushi 
Published: January 2020

Abstract
Background
Pneumoperitoneum commonly occurs as a result of a viscus perforation and usually presents with peritoneal signs requiring emergent laparotomy. Spontaneous pneumoperitoneum is a rare condition characterized by intraperitoneal gas with no clear etiology.

Case presentation
We herein report a case in which conservative treatment was achieved for an 83-year-old male patient with spontaneous pneumoperitoneum that probably occurred due to duodenal diverticulosis. He had stable vital signs and slight epigastric discomfort without any other signs of peritonitis. A chest radiograph and computed tomography showed that a large amount of free gas extended into the upper abdominal cavity. Esophagogastroduodenoscopy showed duodenal diverticulosis but no perforation of the upper gastrointestinal tract. He was diagnosed with spontaneous pneumoperitoneum, and conservative treatment was selected. His medical course was uneventful, and pneumoperitoneum disappeared after 6 months.

Conclusion
In the management of spontaneous pneumoperitoneum, recognition of this rare condition and an accurate diagnosis based on symptoms and clinical imaging might contribute to reducing the performance of unnecessary laparotomy. However, in uncertain cases with peritoneal signs, spontaneous pneumoperitoneum is difficult to differentiate from free air resulting from gastrointestinal perforation and emergency exploratory laparotomy should be considered for these patients.
RETRACTED ARTICLE: Multi-objective energy management in microgrids with hybrid energy sources and battery energy storage systems
Authors: Murty V. V. S. N. , Kumar Ashwani 
Published: January 2020

AbstractMicrogrid with hybrid renewable energy sources is a promising solution where the distribution network expansion is unfeasible or not economical. Integration of renewable energy sources provides energy security, substantial cost savings and reduction in greenhouse gas emissions, enabling nation to meet emission targets. Microgrid energy management is a challenging task for microgrid operator (MGO) for optimal energy utilization in microgrid with penetration of renewable energy sources, energy storage devices and demand response. In this paper, optimal energy dispatch strategy is established for grid connected and standalone microgrids integrated with photovoltaic (PV), wind turbine (WT), fuel cell (FC), micro turbine (MT), diesel generator (DG) and battery energy storage system (ESS). Techno-economic benefits are demonstrated for the hybrid power system. So far, microgrid energy management problem has been addressed with the aim of minimizing operating cost only. However, the issues of power losses and environment i.e., emission-related objectives need to be addressed for effective energy management of microgrid system. In this paper, microgrid energy management (MGEM) is formulated as mixed-integer linear programming and a new multi-objective solution is proposed for MGEM along with demand response program. Demand response is included in the optimization problem to demonstrate it’s impact on optimal energy dispatch and techno-commercial benefits. Fuzzy interface has been developed for optimal scheduling of ESS. Simulation results are obtained for the optimal capacity of PV, WT, DG, MT, FC, converter, BES, charging/discharging scheduling, state of charge of battery, power exchange with grid, annual net present cost, cost of energy, initial cost, operational cost, fuel cost and penalty of greenhouse gases emissions. The results show that CO2 emissions in standalone hybrid microgrid system is reduced by 51.60% compared to traditional system with grid only. Simulation results obtained with the proposed method is compared with various evolutionary algorithms to verify it’s effectiveness.
Assessment of plasminogen activator inhibitor-1 in obese Egyptian children
Authors: Mira Marwa Farouk , Anwar Ghada Mohammad , Sarry EL-Din Azza Mohamed , Megahed Safinaz Mohammed 
Published: January 2020

Abstract
Background
Plasminogen activator inhibitor-1 (PAI-1) is mainly produced in the liver and in the adipose tissue. Normal fibrin clearance mechanisms were found to be affected by high plasma PAI-1 levels and thus increases risk of thrombosis. The aim of the current study was to expound the childhood obesity effect on circulating PAI-1 and interpret the relation of PAI-1 to metabolic syndrome. This cross-sectional study was conducted on 43 obese children following in the Children Hospital and compared to 44 healthy sex- and age-matched controls. All recruited cohort are subjected to anthropometric measurements: weight, height, BMI, waist circumference, hip circumference, and skin fold thickness (biceps, triceps, and subscapular), and laboratory investigations in the form of lipid profile, fasting blood sugar, fasting insulin, insulin resistance estimated by HOMA-IR, and plasminogen activator inhibitor-1.

Results
The level of plasminogen activator inhibitor-1 in the obese group was significantly higher than that in the control group (47.98 ± 17.42 vs. 28.00 ± 11.35 respectively). PAI-1 showed positive significant correlation to anthropometric measurements: BMI (p = 0.000), weight (p = 0.000), biceps skin fold thickness (p = 0.04), triceps skin fold thickness (p = 0.4), and subscapular skin fold thickness (p = 0.04). Also, a significant positive correlation was found between PAI-1 and systolic (p = 0.000) and diastolic blood pressure (p = 0.04). Positive correlations were found between PAI-1 and cholesterol (p = 0.000), triglycerides (p = 0.02), LDL-c (p = 0.000), insulin (p = 0.000), and HOMA-IR (r = 0.5, p = 0.02).

Conclusion
Fat mass accumulation is related to high PAI-1 levels, which might in turn contribute to cardiovascular risk. Plasminogen Activator Inhibitor-1 is a good predictive test for metabolic syndrome in obese children.
What kind of in-patient psychiatry for Africa? Report from Zimbabwe
Authors: Summerfield Derek 
Published: January 2020

SummaryThe expanding global mental health field has paid little attention to evaluating the culture of psychiatry prevailing in in-patient settings across Africa. For example, in Zimbabwe in-patient psychiatry has been heavily pathologising, with over-reliance on the diagnosis of schizophrenia and on antipsychotic polypharmacy. It is not helpful that the next generation of African doctors are learning unmediated Western psychiatry, with little credence given to background cultural factors and mentalities shaping presentations. Some of the psychiatric and social consequences of this for patients in Zimbabwe are discussed.
Neural Determinants of Pulsatile Luteinizing Hormone Secretion in Male Mice
Authors: Han Su Young , Cheong Isaiah , McLennan Tim , Herbison Allan E 
Published: January 2020

Abstract
The gonadotrophin-releasing hormone (GnRH) pulse generator drives pulsatile luteinizing hormone (LH) secretion essential for fertility. However, the constraints within which the pulse generator operates to drive efficient LH pulsatility remain unclear. We used optogenetic activation of the arcuate nucleus kisspeptin neurons, recently identified as the GnRH pulse generator, to assess the efficiency of different pulse generator frequencies in driving pulsatile LH secretion in intact freely behaving male mice. Activating the pulse generator at 45-minute intervals generated LH pulses similar to those observed in intact male mice while 9-minute interval stimulation generated LH profiles indistinguishable from gonadectomized (GDX) male mice. However, more frequent activation of the pulse generator resulted in disordered LH secretion. Optogenetic experiments directly activating the distal projections of the GnRH neuron gave the exact same results, indicating the pituitary to be the locus of the high frequency decoding. To evaluate the state-dependent behavior of the pulse generator, the effects of high-frequency activation of the arcuate kisspeptin neurons were compared in GDX and intact mice. The same stimulus resulted in an overall inhibition of LH release in GDX mice but stimulation in intact males. These studies demonstrate that the GnRH pulse generator is the primary determinant of LH pulse profile and that a nonlinear relationship exists between pulse generator frequency and LH pulse frequency. This may underlie the ability of stimulatory inputs to the pulse generator to have opposite effects on LH secretion in intact and GDX animals.