bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delay in seeking medical care after the onset of symptoms in patients with sight-threatening diabetic retinopathy
Authors: Wei Yan , Mi Fenghua , Cui Yan , Li Ying , Wu Xinyi , Guo Hui 
Published: January 2020

Abstract
Background Diabetic retinopathy (DR) is a common diabetes-associated complication and a primary cause of blindness. One of the critical factors affecting timely and effectual therapy for DR is the delay in treatment after the onset of symptoms. The present study aimed to investigate the reasons for the delay in the treatment of the condition and the risk factors associated with the delay. Methods We retrospectively reviewed data from 127 patients with sight-threatening diabetic retinopathy (STDR) treated at Qilu Hospital of Shandong University in China. Various forms of STDR were identified including severe non-proliferative DR, clinically significant macular edema (CSME) and proliferative DR(PDR). Information concerning demography, clinical, and socioeconomic status of the patients was gathered. Risk factors associated with the delay was evaluated using logistic regression analysis. Results Among 127 patients with STDR, 89.2% sought medical care one month after the onset of symptoms. Patients who sought for treatment 6 months post-symptom onset had significantly lower income and less knowledge about diabetic eye complications than those presenting within 6 months. Multivariate logistic regression analysis showed that never or infrequent routine examination for diabetic complications was associated with a long delay in seeking medical care (odds ratio 3.06, 95% CI 1.05-9.19, p <0.05; odds ratio 2.91, 95% CI 1.04-8.40, p <0.05). Conclusions Most STDR patients sought medical care one month after the onset of symptoms. Never or infrequent routine examination for diabetic complications was associated with a long delay. The results of the present study stress the necessity to implement educational programs on diabetic complications to encourage early medical care and prevent disastrous outcomes.
Preparation and bioactivity of anti-Newcastle disease virus-phosphoprotein cytoplasmic transduction peptide antibody
Authors: Li Benqiang , Wang Man , Zhu Jianguo 
Published: January 2020

Abstract
On the basis of cell-penetrating peptide’s character that it can penetrate cytomembrane and transfer macromolecular protein to cytoplasm so to play biological function, we took the experiments. The fuse penetrating peptide our experiment adoptted is HIV-TAT derived fragment-CTP512, with good transmember effect and distinct cytoplasm-position. In this chapter, the research of transmembrane character was processed first. According to the tests on trans- member protein with different concentrations, the best trans-member concentration is 3µM. Afterwards, we found that the location of trans-member antibody is overlapping with phosphoprotein using indirect immunofluorescence test analysis. According to MTT test, there is no significant difference between CTP fusion protein and control on cell proliferation and viability. TCID50 test was used to detect the protective effect of trans-member antibody on cell. Result showed that trans- member antibody has significant cell protection effect compared to the control in the order: ZL.103>ZL.17>Control. Fluorogenic quantitative PCR result showed that trans- member antibody can disturb the duplication and transcription of Newcastle disease virus. This results not only paved a good way to research the transport of disease related protein, but also provide a splendid tool on protein function research.
Baseline studies on the health of marsh deer (Blastocerus dichotomus) populations from Argentina: laying the grounds for an improved interpretation of mortality episodes
Authors: Orozco Maria Marcela , Argibay Hernán D. , Minatel Leonardo , Guillemi Eliana C. , Berra Yanina , Schapira Andrea , Nucci Dante Di , Marcos Andrea , Lois Fernanda , Falzone Martin , Farber Marisa D. 
Published: January 2020

Abstract
Background: The comprehensive approach to diseases in broad ecological contexts appears as a new challenge for global health and draws on baseline studies to detect changes in the occurrence of pathogens over time. Marsh deer (Blastocerus dichotomus) mortality episodes were described in Argentina and several pathogens associated with environmental and eco-epidemiological factors were indicated as risk factors. To date, the lack of basic health information on these populations has hampered interpretation of findings. This study aimed to provide baseline data on health parameters in marsh deer populations from Argentina. Results: Between May 2014 and December 2016 we determined health parameters in 44 marsh deer with different body condition scores, and studied the pathological lesions in dead animals. Marsh deer with poor body condition had a high burden of the ticks Amblyomma triste and Rhipicephalus microplus. Vector borne agents (VBAs), such as Theileria cervi. Trypanosoma theileri, Trypanosoma evansi, Ehrlichia chaffeensis, Anaplasma platys, Anaplasma odocoilei, Anaplasma marginale, and Candidatus Anaplasma boolense were also found. Haemonchus spp, Ostertagia spp., Trichostrongylus spp. showed the highest infection prevalence. A Multiple Correspondence Analysis suggested a possible association of i) lower body score condition with high tick loads and infection with VBAs and, ii) the impoverished body score with high loads of nemathelminths and well-known harmful gastrointestinal parasites. Conclusions: Our results contribute with knowledge on the life history and health aspects of marsh deer in the study areas. We provide data on the prevalent infectious and parasitic agents in their populations. A range of haematology and serum chemistryvalues, and the occurrence of Fasciola hepatica and Leptospira interrogans serovar pyrogenes were reported for the first time in wild marsh deer from Argentina. The histopathological findings in succumbed animals allowed us to recognize injuries associated or not with their body condition. Our results are the first step in the creation of a baseline on marsh deer health in Argentina. In the future, these data added to new contributions could help improve the interpretation of the findings during mortality events.
Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization
Authors: Chen Yu-Chen , Lai Yun-Ju , Su Yu-Ting , Tsai Ni-Chin , Lan Kuo-Chung 
Published: January 2020

Abstract
Background Very few previous studies have examined the effect of endocrine parameters during ART on preeclampsia. Moreover, there is little known about the relationship of steroid hormone levels on development of the placenta. The purpose of this study is to assess the association of preeclampsia with serum estradiol (E2) and progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods This was a hospital-based cohort study using clinical data from the Kaohsiung Chang Gung Memorial Hospital Obstetric and Neonatal Database (KCGMHOND) from Jan 1, 2001 to December 1, 2018. Eligible women underwent at least one autologous IVF/ICSI cycle and had a live-born infant with a gestational age (GA) of more than 20 weeks. Results A total of 622 women who had live births after fresh IVF/ICSI-ET during the study period met our inclusion criteria. Twenty-eight women (4.5%) met the diagnostic criteria for preeclampsia. However, women in the preeclampsia group had a significantly higher body mass index (22 vs. 24, p =0.05), body weight at delivery (70.0 vs. 80.5 kg, p <0.001) and gestational weight gain (13.0 vs. 19.6 kg, p =0.002) and had lower use of ICSI (29.9% vs. 10.7%, p =0.021). Logistic regression analysis of the relationship of patient and treatment characteristics with preeclampsia. The crude ORs indicated that young female age >34, not using ICSI, E2 peak <1200 pg/mL and gestational weight gain >20 kg were associated with preeclampsia. After adjustment for confounding, the only factors that remained significant were E2 peak <1200 pg/mL (aOR = 4.634, 95% CI = 1.061 to 20.222), and gestational weight gain >20 kg (aOR: 13.601, 95% CI: 3.784, 48.880). Conclusions For women receiving IVF/ICSI, lower estradiol hormone levels on the day of hCG administration and higher pregnancy weight gain are related with subsequent preeclampsia.
Routine Health Information System in the Health Facilities in Yaoundé-Cameroon: Assessing the Gaps for Strengthening
Authors: Tamfon Brian Bongwong , Ndongo Chanceline Bilounga , Bataliack Serge Marcial , Ngoufack Marie Nicole , Nguefack-Tsague Georges 
Published: January 2020

Abstract
Background Management of health data and its use for informed decision making is a challenging health sector aspect in developing countries. Monitoring and evaluation of health interventions for meeting health-related Sustainable Development Goals (SDGs), and Cameroon Health Sector Strategy (HSS) targets is facilitated through evidence-based decision-making and public health action. Thus, a Routine Health Information System (RHIS) producing quality data is imperative. The objective of this study was to assess the RHIS in the health facilities (HFs) in Yaoundé in order to identify gaps and weaknesses and to propose measures for strengthening. Methods A health facility-based cross-sectional descriptive study was carried out in the six health districts (HDs) of Yaoundé; followed by a qualitative aspect consisting of in-depth interviews of key informants at the Regional Health Office. HFs were selected using a stratified sampling method with probability proportional to the size of each HD. Data were collected (one respondent per HF) using the World Health Organization (WHO) and MEASURE Evaluation RHIS rapid assessment tool. Data were entered into Microsoft Excel 2013 and analyzed with IBM-SPSS version 20. Results A total of 111 HFs were selected for the study. Respondents aged 24-60 years with an average of 38.3±9.3 years; 58 (52.3%) male and 53(47.7%) female. Heads of HFs and persons in charge of statistics/data management were most represented with 45.0% and 21.6% respectively. All the twelve subdomains of the RHIS were adequately functioning at between 7% and 30%. These included Human Resources (7%), Data Analysis (10%), Information and Communication Technology (11%), Standards and System Design (15%), Policies and Planning (15%), Information Dissemination (16%), Data Demand and Use (16%), Management (18%), Data Needs (18%), Data Quality Assurance (20%), Collection and Management of Individual Client Data (26%), Collection, Management, and Reporting of Aggregated Facility Data (30%). Conclusions The level of functioning of subdomains of the RHIS in Yaoundé was low; thus, immediate and district-specific strengthening actions should be implemented if health-related SDGs and HSS targets are to be met. A nation-wide assessment should be carried out in order to understand the determinants of these poor performances and to strengthen the RHIS.
VIVÊNCIAS DE PRAZER E SOFRIMENTO NO TRABALHO: o caso de policiais militares de uma cidade do interior
Authors: Silva Dara Heleno da , Marra Adriana Ventola 
Published: January 2020

Este artigo teve como objetivo descrever e analisar as vivências de prazer e sofrimento no trabalho dos policiais militares de uma cidade do interior de Minas Gerais. Este estudo caracterizou-se por ser qualitativo descritivo. Foram realizadas sete entrevistas semiestruturadas com policiais militares da cidade pesquisada. Os dados foram analisados por análise de conteúdo. Identificou-se o local de trabalho, o sentimento de utilidade, o reconhecimento e os relacionamentos no trabalho como vivências de prazer. A respeito do sofrimento, foram: falta de reconhecimento social, remuneração, medo e interferência na vida pessoal. Concluiu-se que o aumento da criminalidade no interior não foi considerado como fonte de sofrimento, a partir do efeito de comparação com outras cidades.
Градопреобразующая роль инновационной деятельности
Authors: Bocharov Yuri , Frezinskaya Nataliya , Kirill Sergeyev 
Published: January 2020

В статье охарактеризована пространственная организация инновационной деятельности в городах России и её столице, отмечены быстрое развитие цифровых технологий, способ­ствующее вхождению России в число стран - инноваторов рейтинга Bloomberg-2018, возможности использования потенциала, накопленного в сфере исследований и разра­боток, для совершенствования производства, образования, строительства, здравоохранения и коммунального хозяйства. Инновационная деятельность в России становится инструмен­том совершенствования градостроительной среды, однако в производстве инноваций федеральные округа и входящие в них города участвуют с разной активностью.
В Центральном округе сосредоточивается более половины занятых исследованиями и разработками, а в Москве - чуть менее трети. В столице организуется единый инновационный кластер (ИК), включающий учреждения Российской академии наук, Московский государственный университет, технические вузы, технопарки, ИТ - компании, бизнес-инкубаторы и другие связанные с ними объекты. Идет процесс создания высокотех­нологичных предприятий, производительность труда превыша­ет средние показатели по стране в 2,5 раза. В конструкторском бюро Российской самолетостроительной компании МиГ (РСК «МиГ») разрабатываются прогрессивные технологии, создают­ся новые и совершенствуются существующие виды продукции. Инноград «Сколково» готовит магистров и аспирантов для работы в области информационных технологий, энергетики, биомедицины и космической медицины.
Московский опыт распространяется на удалённые регионы России, включая кризисные города (например, Новокузнецк и Тольятти). В статье намечены пути оживления кризисных городов Европейской и Азиатской частей страны и ставится задача создания модели эффективного градопреобразования с использованием инструментов инновационной деятельности.
Hemorragia digestiva en paciente con hiperplasia de glándulas de Brunner
Authors: Sánchez-Aldehuelo Rubén , Ruiz-Cobo Juan Carlos , Senosiain Lalastra Carla , Tavío Hernández Eduardo , Perna Monroy Cristian , Albillos Agustín 
Published: January 2020

Objetivo: analizar las características epidemiológicas, bases etiopatogénicas y presentación clínica, así como el diagnóstico y el tratamiento de la hiperplasia de glándulas de Brunner (HGB).
Métodos: describir un caso de HGB diagnosticado de forma incidental durante una endoscopia electiva y realizar una revisión de la literatura disponible hasta el momento.
Resultados: esta neoformación consiste en una proliferación glandular localizada preferentemente en el duodeno proximal. Su diagnóstico, normalmente realizado mediante biopsia endoscópica, puede asociarse con complicaciones que, aunque infrecuentes, no deben ser subestimadas.
Conclusiones: las neoplasias duodenales representan un porcentaje pequeño dentro del total de las que afectan al tracto gastrointestinal. Debido a que el diagnóstico de estas lesiones suele realizarse de forma casual durante una endoscopia programada, el tratamiento deberá basarse en la sintomatología, así como el tamaño de las mismas, de acuerdo con los estándares de tratamiento de cada centro.
Factibilidad financiera de infraestructura solar para pequeños y medianos agricultores y productores de nuez en Delicias, Chihuahua
Authors: Hernández Salas José Esteban , Márquez Fierro Walter , Pérez Jerónima Antonieta , Macías López María Guadalupe 
Published: January 2020

La producción sostenible de energía eléctrica ha cobrado cada vez mayor preponderancia en el desenvolvimiento de todas las actividades humanas. De las muchas actividades humanas que son fundamentales garantizar su sustentabilidad, la producción agrícola es vital, puesto que la accesibilidad a los alimentos es uno de los mayores logros en los que ha podido avanzar la humanidad. Con la visión de buscar que la actividad agrícola de México se direccione a la vanguardia energética, este estudio se propuso determinar la factibilidad que puede tener la implementación de paneles solares para irrigación fotovoltaica en nogaleras en comunidades de pequeños y medianos agricultores de la región de Delicias, Chihuahua, México. Para ello se procedió a hacer un estudio de campo con productores de la región para evaluar los costos financieros y las infraestructuras necesarias para la implementación de dicha tecnología. El análisis respectivo arrojó resultados que mostraron que no es factible la inversión financiera de productores en paneles solares que puedan almacenar y conducir la energía solar necesaria en el bombeo para irrigación de nogaleras de la región por los altos costos de inversión inicial que requieren, así como unas tasas de retorno de inversión que oscilan entre 9 % y 13 % después de los 20 meses. En conclusión, actualmente se evidencia que la competitividad en el mercado y la sostenibilidad a largo plazo de los recursos energéticos siguen siendo conceptos dicotómicos, lo que hace imperativo seguir estudiando las posibilidades de tender puentes que garanticen un futuro energético sostenible para las comunidades agrícolas de la región.
JENIS KAPABILITAS DINAMIS PELAKU RINTISAN START UP ENTREPRENEUR (Studi Pada Pelaku Subsektor Gastronomi di Industri Kreatif)
Authors: Sugiono Arif , Fordian Dian 
Published: January 2020

The purpose of this study was to identify the types of dynamic capabilities for start-up entrepreneurs in the creative industries gastronomy sub-sector where the Organization Life Cycle stage is at the entrepreneurial stage. The method used was a snapshot case study with a naturalistic descriptive type. The informants were determined using purposive techniques with some criteria that are in accordance with the focus and locus of research. Data were collected through in-depth interviews, observation, and literature study. Data were analyzed using an interactive model. The results showed that there are several types of dynamic capabilities that start-up entrepreneurs need: the ability to choose and design organizational structures, the accuracy of the choice of information technology types, and the ability to design market-oriented strategies. Based on the results of the research above, the startup entrepreneurs are required to have a renewal ability to sustain managerial skills to analyze and adapt to the dynamics of the internal and external environment that changes amicably. Tujuan penelitian ini adalah mengidentifikasi jenis kapabilitas dinamis yang diperlukan bagi para pelaku start up entrepreneur di sub sektor gastronomi industri kreatif yang tahap Organization Life Cycle berada pada tahap entrepreneurial. Metode yang digunakan adalah snapshoot case study dengan type deskriptif naturalistic. Penentuan informan menggunakan teknik purposive, dengan beberapa krieria yang sesuai dengan fokus dan lokus penelitian. Teknik pengambilan data melalui wawancara mendalam, observasi dan studi pustaka. Analisis data menggunakan model interaktif. Hasil penelitian menunjukkan ada beberapa jenis kapabilitas dinamis yang sangat diperlukan bagi pelaku rintisan start up entrepreneur, yaitu kemampuan memilih dan mendesain struktur organisasi, ketepatan pemilihan jenis teknologi informasi dan kemampuan mendesain strategi yang berorientasi pasar. Berdasarkan hasil penelitian di atas, maka pelaku rintisan start up entrepreneur dituntut untuk memiliki renewal ability untuk menopang managerial skill, sehingga mampu menganalisa dinamika lingkungan internal dan eksternal.
INCORPORATING TIMBER EDUCATION INTO EXISTING ACCREDITED ENGINEERING PROGRAMS
Authors: Chorlton Bronwyn , Mazur Natalie , Gales John 
Published: January 2020

The demand for large and tall timber buildings is increasing across Canada. The recently constructed Brock Commons building in Vancouver and the upcoming Arbour building in Toronto are two such examples. These buildings are challenging for practitioners to design, and presently only a limited number of engineering institutions across Canada offer a course in timber design. There is a growing demand for engineering graduates who can contribute to the creation of these structures; however, the number of graduates who meet this criterion is lagging. Separate courses in timber could be introduced to more universities, however the addition of a new course may overload students, whose course schedules are already tightly regulated by the Canadian Engineering Accreditation Board. Moreover, the creation of a new course can take several years and will therefore not meet the current industry demand quick enough. The research herein presents a method of incorporating timber education within the existing civil engineering curriculum in Canada, without the introduction of an additional course. The purpose of the proposed method is to offer an efficient solution that will provide engineering students with knowledge of the timber industry quickly to meet industry demand. Two timber learning modules were integrated within the existing Structural Steel Design course at an accredited university. The timber learning modules paralleled the topics covered within an undergraduate timber design course. Students were surveyed before and after the learning modules were presented to assess level of interest and motivations, knowledge of the industry, and level of understanding. After the learning modules were presented, 76% of students indicated they had some level of confidence in contributing to the design of a timber building. These results show that the timber learning modules were successful at introducing and generating an interest in timber design, and that students gained basic knowledge they could apply in practice.
Adenoid hypertrophy among school-aged Iraqi children, the effect of severity and duration on its co-morbidities
Authors: Hulal Saleh Sahib  
Published: January 2020

Adenoid hypertrophy is a common pediatrics health problem that usually results in several morbidities such as sleep disorder, adenoid facies, impaired physical growth, cardiac complications, glue ear and nocturnal enuresis. Patients and methods: Forty-two school-aged children were enrolled in this study (6-12 years old), thirty were male and twelve were female, all are suffering from chronic snoring. All of them were subjected to standard history and physical examination to the most related health problems such as assessment of physical growth, craniofacial malformation, associated tonsillar enlargement. Investigations were performed in the form of lateral neck X-ray and ECG for all of them. The study period was 9 months from 1st of March 2018 to the 1st of December 2018. Results: There was a significant association between a higher grade of disease and speech disorders, tonsillar hypertrophy, adenoid facies, recurrent otitis media, nocturnal enuresis, impaired school performance, physical growth impairment, apnea at sleep, day time drowsiness, ECG abnormalities and deglutition problems (P < 0.05). The associated co-morbidities, namely Speech disorders, tonsillar hypertrophy, adenoid facies, recurrent otitis media, nocturnal enuresis, impaired school performance, impaired school performance, physical growth impairment, apnea at sleep, day time drowsiness, ECG abnormalities and deglutition problems, were significantly correlated to the longer duration of disease. Conclusion: Longer duration of disease and higher grade of adenoid hypertrophy are strongly correlated with disease complications and morbidities, hence early diagnosis and properly timed management is important to prevent these complications.