bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan antara pengasuhan orangtua dengan masalah makan pada anak usia prasekolah
Authors: Riswan Riswan , Yunitasari Eva 
Published: September 2020

Parenting is very important in the child’s psychological growth and development, the child’s ability to socialize, children’s independence, and difficult eating behavior in children. Because of the phenomenon that often arises is the child has difficult eating which is influenced by parenting parents. This research objective was to determine the correlation between parenting parents with difficult eating behavior on children’s pre-school age at the Sindang Garut village of Way Lima sub-district in Pesawaran Regency. This research was quantitative type with cross sectional approach to the sampling technique used is purposive sampling. The sample were 30 respondents. Data collection used questionnaire sheets and it used gamma statistical tests. The results showed that parenting parents applied were democratic parenting (56.7 percent), and difficult eating behavior in children’s pre-school age at the Sindang Garut village with low intensity (73.3 percent) with p value of 0.006 less than 0.05, which means there is a correlation between parenting parents with difficult eating behavior in children’s pre-school age at the Sindang Garut village of Way Lima sub-district in Pesawaran Regency. So this research is expected to be a source of reference and information for parents about the importance of parenting because it can influence the behavior of eating difficulties on children. Abstrak: Pola asuh orang tua sangat penting dalam tumbuh kembang anak dalam psikologis anak, kemampuan bersosialisasi anak, kemandirian anak, serta perilaku sulit makan pada anak. Karna fenomema yang sering muncul adalah anak mengalami sulit makan yang dipengaruhi oleh pola asuh orang tua. Penelitian ini bertujuan untuk mengetahui hubungan pola asuh orang tua dengan perilaku sulit makan pada anak usia prasekolah di desa sindang garut kecamatan way lima kabupaten pesawaran. Penelitian ini merupakan jenis peneltian kuantitatif dengan pendekatan Cross Sectional teknik pengambilan sampel yang digunakan adalah purposive sampling. dengan jumlah sampel 30 responden. Pengumpulan data menggunakan lembar kuesioner dan uji statistik gamma. Hasil penelitian menunjukan mayoritas pola asuh yang diterapkan adalah pola asuh demokratis (56,7 persen), dan perilaku sulit makan pada anak di desa sindang garut dengan intensitas rendah (46,7 persen) dengan nilai p value 0,006 kurang dari 0,05, yang artinya ada hubungan pola asuh orang tua dengan perilaku sulit makan pada anak usia prasekolah di desa sindang garut kecamatan way lima kabupaten pesawaran. Maka penelitian ini diharapkan bagi orang tua agar dapat menerapkan pola asuh demokratis sehingga dapat mengurangi kejadian sulit makan pada anak usia prasekolah.
PALABRAS CENTRALES DEL DECANO POR EL 38 ANIVERSARIO DE LA FACULTAD DE CIENCIAS JURIDICAS Y POLITICAS DE LA UNA-PUNO
Authors: Espezúa Salmón Boris Gilmar 
Published: September 2020

Dr. Peter Manzaneda, Director de Departamento. Dr. Carlos Ramírez. Director de Escuela. Dr. Juan Casazola Director de la Unidad de Postgrado en Derecho. Dra. Diana Dueñas, Directora de la Oficina de Investigación. Apreciados Colegas docentes, compañeros administrativos, estimados estudiantes de nuestra Facultad de Ciencias Jurídicas y Políticas. El 8 de agosto de todos los años celebramos nuestro aniversario desde hace 38 años atrás. Y es motivo para rememorar una trayectoria espléndida que hemos tenido, pero también para visionar el futuro que tenemos que surcar. Y es en esa perspectiva que tenemos que saber enrumbar nuestras acciones para que mantengamos por un lado el pedestal de prestigio y reconocimiento social que con esfuerzo y dedicación lo hemos obtenido, pero también por otro lado despuntar mejores horizontes a fin de constituirnos en la mejor Facultad de Derecho del sur del Perú, porque las condiciones académicas, como las humanas nos permitirán alcanzar mejores y elevadas cumbres de progreso y consolidación, con lo cual no es un despropósito anhelar dicha meta.
Humorous expression reenacted in translation: the recreation of three characters from Stephen Leacock’s sunshine sketches
Authors: Gonçalves Davi Silva 
Published: September 2020

This article on my proposal of an annotated translation of Stephen Leacock’s comic novel Sunshine Sketches of a Little Town (1912) comprises the scrutiny of a rather non-hegemonic and overlooked discursive literary channel: humour. My analysis of the novel and reflection upon some of the excerpts translated elaborate upon the role of the translator as an active agent for the diffusion of epistemologies that deviate from normativity – highlighting how the translation of comic effects contribute to the dissemination of such deviation in time and space.
Imagem corporal masculina: revisão integrativa da produção científica latino-americana (2005-2019)
Authors: Martins Alberto Mesaque , Nascimento Adriano Roberto Afonso do 
Published: September 2020

Esse estudo tem como objetivo realizar uma revisão integrativa da literatura científica latino-americana, dos últimos 15 anos, acerca dos aspectos socioculturais que perpassam a imagem corporal masculina. Na perspectiva das pesquisas de Revisão Integrativa, foram analisados 115 artigos, disponíveis nas bases virtuais Lilacs, SciELO e PePsic, publicados no período entre 2005 a 2019. O conjunto de estudos analisados revela a centralidade dos aspectos socioculturais na construção da imagem corporal masculina e no modo como os homens percebem e utilizam os seus próprios corpos, cotidianamente. Em diferentes contextos, os homens vivenciam uma forte pressão social para adequação dos seus corpos aos padrões hegemônicos de beleza e aos ideais de masculinidades socialmente difundidos e compartilhados, interferindo, assim, em suas percepções acerca de seus próprios corpos e delineando comportamentos alimentares e práticas de exercícios físicos que, muitas vezes, comprometem a saúde.
A transformação didático-pedagógica da ginástica para as crianças pelo “brincar e se-movimentar”
Authors: Costa Andrize Ramires , Rigo Luiz Carlos , Marques Danieli Alves Pereira , Assis Marília Del Ponte de 
Published: September 2020

O objetivo do ensaio é refletir e problematizar o “brincar e se-movimentar” na ginástica como possibilidade pedagógica de uma Educação Física centrada no sujeito, perspectivando a ampliação do campo existencial. Considerando que o agir humano é carregado de intencionalidade e conexão entre corpo-mundo, defende-se uma ginástica que fomente a realização de experiências corporais por meio da resolução de problemas e da participação das crianças nas aulas com autonomia, criatividade e liberdade, permitindo-lhes constituir sentidos outros naquilo que fazem, pensam e sentem, dialogando com o mundo numa aventura saudável que as convida para se desenvolver no decurso de infinitas possibilidades de ação.
Unusual suspects: Real-time physiological evaluation of stressors during laparoscopic donor nephrectomy
Authors: Wilson Claire , Chahine Saad , Cristancho Sayra , Aquil Shahid , Mandurah Moaath , Levine Max , Sener Alp 
Published: September 2020

Introduction: The purpose of this study was to document the variability of faculty surgeon electrodermal activity (EDA) peaks during laparoscopic donor nephrectomy (LDN) to determine the effect of case difficulty and learner expertise on the stress response.
Methods: EDA for a single faculty surgeon was captured over 15 LDN cases using an Empatica E4 wristband. During each case, one of three transplant fellows (novice, intermediate, or expert level LDN expertise) participated. Difficulty was rated preoperatively as “low/moderate/high” by the faculty. EDA peaks were collected and analyzed; the frequency and magnitude of EDA peaks, case difficulty, and fellow expertise were compared using a two-way factorial ANOVA.
Results: The main effects of learner expertise (F[2, 308]=11.27, p<0.001) and difficulty rating (F[2, 414]=15.13, p<0.001) were significant. The interaction between difficulty and expertise on faculty EDA peaks was also significant (F[3, 391]=14.29, p<0.001). The novice fellow resulted in higher faculty EDA levels compared to intermediate and expert fellows on low-difficulty cases, but not moderate- or high-difficulty cases.
Conclusions: This is the first report examining faculty surgeon EDA across cases of varying difficulty and varying learner expertise during a high-stakes operation. EDA levels were inversely proportional to the expertise of the learner and case difficulty, suggestive of a significant impact of learner autonomy on faculty stress response.
Initial Evaluation of Rapid, Direct-to-Digital Prostate Biopsy Pathology
Authors: Torres Richard , Olson Eben , Homer Robert , Martin Darryl T. , Levene Michael J. , Perincheri Sudhir , Sprenkle Preston C. , Humphrey Peter A. 
Published: September 2020

Context.—
Pathologist interobserver discordance is significant in grading of prostate cancer, limiting reliability. Diagnostic reproducibility may be improved with digital images, but adoption faces workflow, cost, and quality challenges. A novel digital method using an alternative tissue processing approach and novel laser microscopy system potentially addresses these issues.

Objective.—
To evaluate the capability of this new method for primary diagnostic interpretation in clinical prostate biopsy specimens.

Design.—
Forty patients with a high likelihood of prostate cancer based on magnetic resonance imaging consented to investigational core biopsy. A subset of samples was used for direct comparison of physical slide preparation effects and time-tracking determination with multiphoton microscopy. Twenty samples were processed for diagnostic comparison between multilevel digital slides and subsequently produced physical slides. A reference diagnosis based on all data was established using grade groups. Level of diagnostic match and requests for immunohistochemistry were compared between physical and digital diagnoses. Immunohistochemical staining and length measurements were secondary outcomes.

Results.—
Interpretations based on direct multiphoton imaging yielded diagnoses that were at least as accurate as standard histology; cancer diagnosis correlation was 89% (51 of 57) by physical slides and 95% (53 of 56) by multiphoton microscopy. Grade-level concordance was 73% (44 of 60) by either method. Immunohistochemistry for routine prostate cancer–associated markers on these alternatively processed tissues was unaffected. Alternatively processed tissues resulted in longer measured core and cancer lengths, suggestive of improved orientation and visualization.

Conclusions.—
Findings support high potential for complete interpretation of prostate core biopsies using solely multiphoton microscopy of intact specimens, with potential diagnostic benefits as well as reduced processing time and reduced processing complexity.
Expression of collagen type 1 alpha 1 indicates lymph node metastasis and poor outcomes in squamous cell carcinomas of the lung
Authors: Dong Siyuan , Zhu Peiyao , Zhang Shuguang 
Published: September 2020

Background
Squamous cell carcinomas of the lung are an extremely common and deadly form of non-small cell lung cancers. Clinical management of the disease is dependent on staging and metastatic status. Metastasis to the lymph node is especially crucial to diagnose as it occurs at an earlier stage. However, lymphadenectomies are invasive and tumor cells may be overlooked during evaluation.There are limited approved biomarkers for predicting lymph node metastasis with squamous cell carcinomas of the lung (LSCC).

Methods
Genome data of 60 tumor-adjacent samples were downloaded from Genome Expression Omnibus. We identified over-expressed HUB genes using Cytoscape as key prognostic markers. The selected markers were further evaluated based on gene ontology and overall expression levels compared to normal tissue using The Cancer Genome Atlas. We further validated these results using clinical biopsy tissue taken from squamous cell carcinoma patients.

Results
Analysis of the genome expression data resulted in 13 relevant hub genes that were differentially expressed in cancerous samples. All of these genes are associated with collagen biosynthesis within the tumor microenvironment. We chose Collagen Type 1 Alpha 1 (COL1A1) as the most relevant prognostic marker due to its high number of pathway connections and over expression in the tumor microenvironment compared to the other 12 genes. Additionally, based on analysis of The Cancer Genome Atlas, tumors with higher levels of COL1A1 expression are associated with poorer overall survival. Finally, evaluation of clinical biopsy samples suggests that overexpression of COL1A1 in the LSCC microenvironment highly correlates with lymph node metastasis. These results suggest COL1A1 is a clinically relevant marker that should be used to justify lymphadenectomies.
A glycolysis-related gene pairs signature predicts prognosis in patients with hepatocellular carcinoma
Authors: Zhou Weige , Zhang Shijing , Cai Zheyou , Gao Fei , Deng Wenhui , Wen Yi , Qiu Zhen-wen , Hou Zheng-kun , Chen Xin-Lin 
Published: September 2020

Background
Hepatocellular carcinoma (HCC) is one of the most universal malignant liver tumors worldwide. However, there were no systematic studies to establish glycolysis‑related gene pairs (GRGPs) signatures for the patients with HCC. Therefore, the study aimed to establish novel GRGPs signatures to better predict the prognosis of HCC.

Methods
Based on the data from Gene Expression Omnibus, The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium databases, glycolysis-related mRNAs were used to construct GRGPs. Cox regression was applied to establish a seventeen GRGPs signature in TCGA dataset, which was verified in two validation (European and American, and Asian) datasets.

Results
Seventeen prognostic GRGPs (HMMR_PFKFB1, CHST1_GYS2, MERTK_GYS2, GPC1_GYS2, LDHA_GOT2, IDUA_GNPDA1, IDUA_ME2, IDUA_G6PD, IDUA_GPC1, MPI_GPC1, SDC2_LDHA, PRPS1_PLOD2, GALK1_IER3, MET_PLOD2, GUSB_IGFBP3, IL13RA1_IGFBP3 and CYB5A_IGFBP3) were identified to be significantly progressive factors for the patients with HCC in the TCGA dataset, which constituted a GRGPs signature. The patients with HCC were classified into low-risk group and high-risk group based on the GRGPs signature. The GRGPs signature was a significantly independent prognostic indicator for the patients with HCC in TCGA (log-rank P = 2.898e−14). Consistent with the TCGA dataset, the patients in low-risk group had a longer OS in two validation datasets (European and American: P = 1.143e−02, and Asian: P = 6.342e−08). Additionally, the GRGPs signature was also validated as a significantly independent prognostic indicator in two validation datasets.

Conclusion
The seventeen GRGPs and their signature might be molecular biomarkers and therapeutic targets for the patients with HCC.
Nematocidal Activity on Onchocerca ochengi, Toxicity and Phytochemical Screening of Vernonia perrottetii Sch. Bip. Ex Walp (Asteraceae) Extracts
Authors: Elodie Megnigueu Mimi , Francis Nveikoueing , Sidoine Ngatcha Zouakeu Katoucha , Elysee Djedoubouyom Name , Siméon Kouam Fogue , Dieudonné Ndjonka 
Published: September 2020

Onchocerciasis is a disease caused by a parasitic nematode Onchocerca volvulus in human. Ivermectin who is the main drug recommended for the treatment of this disease is only effective against the microfilarial stage of the parasite. Reports of emergence of parasite resistance to ivermectin have complicated onchocerciasis treatment and require to discover novel drugs. The objective of the present study was to investigate in vitro anthelmintic properties against the cattle ﬁlarial parasite Onchocerca ochengi, a model closely related to Onchocerca volvulus; and evaluate the toxicity (in vivo) of local medicinal plant Vernonia perrottetii. This plant is used as alternative medicine in the treatment of human onchocerciasis in central and coastal regions of Cameroon. Fifteen crude extracts were prepared from various parts of V. perrottetii using three organic solvents (70% ethanol, methanol, methylene chloride) and distilled water. The nematocidal activity was evaluated on adult worms of O. ochengi, worm viability was assessed biochemically using the dimethylthiazol (MTT) formazan assay. Oral toxicity of the promising extract was investigated in mice. The ethanolic extracts of the leaves and roots of V. perrottetii recorded the highest activities against adult male worms (LC50 of 29.80 μg/mL for leaves and 39.36 μg/mL for root). By contrast, the methanol and aqueous extracts of leaves and roots, of the plant as well as the mixture methylene chloride/methanol extracts. For acute treatment, a single dose of 2000 mg/kg no induced critical behavioral changes or death. In sub- acute treatment, daily oral administration of hydro-ethanolic extracts of leaves at the dose of 250, 500 and 750 mg/kg revealed disturbances in the normal growth of animals as well as liver and kidney alterations. Phytochemical analysis of the active extracts revealed the presence of Polyphenols, tannins, saponins and flavonoids. This study revealed the anti-Onchocerca activities of V. perrottetii, indicating a possible new source for developing a phytomedicine or drug for the treatment of human onchocerciasis.
Technical note: Vendor‐agnostic water phantom for 3D dosimetry of complex fields in particle therapy
Authors: Schuy Christoph , Simeonov Yuri , Durante Marco , Zink Klemens , Weber Uli 
Published: September 2020

AbstractPurposeThree‐dimensional (3D) dosimetry is a necessity to validate patient‐specific treatment plans in particle therapy as well as to facilitate the development of novel treatment modalities. Therefore, a vendor‐agnostic water phantom was developed and verified to measure high resolution 3D dose distributions.MethodsThe system was experimentally validated at the Marburger Ionenstrahl‐Therapiezentrum using two ionization chamber array detectors (PTW Octavius 1500XDR and 1000P) with 150.68 MeV proton and 285.35 MeV/u 12C beams. The dose distribution of several monoenergetic and complex scanned fields were measured with different step sizes to assess the reproducibility, absolute positioning accuracy, and general performance of the system.ResultsThe developed system was successfully validated and used to automatically measure high resolution 3D dose distributions. The reproducibility in depth was better than ±25 micron. The roll and tilt uncertainty of the detector was estimated to be smaller than ±3 mrad.ConclusionsThe presented system performed fully automated, high resolution 3D dosimetry, suitable for the validation of complex radiation fields in particle therapy. The measurement quality is comparable to commercially available systems.
Testing a modified cognitive interview with category clustering recall in Iran
Authors: Shahvaroughi Ahmad , Bahrami Ehsan Hadi , Hatami Javad , Monajem Arash , Paulo Rui M. 
Published: September 2020

SummaryThe cognitive interview (CI) has been an effective method for interviewing eyewitnesses often leading to changes in legislation and practice in many countries. This study was the first to employ the CI in Iran and test whether category clustering recall (CCR) was superior to a free recall when incorporated within an investigative interview. A between‐subjects design assigned 66 participants to one of three interview conditions after they watched a mock robbery. The participants were interviewed 48 hr later using either a structured interview (SI), the CI, or a modified cognitive interview (MCI) that replaced free recall with CCR at the first retrieval attempt. Analysis of variance suggests CCR was more effective than free recall and the CI group recalled more information than the SI group, replicating the CI superiority effect. This has implications for law enforcement in Iran and worldwide by suggesting these techniques can be used to enhance recall.
Supramolecular Two‐Dimensional Systems and Their Biological Applications
Authors: Kim Taeyeon , Park Jung Yeon , Hwang Jiwon , Seo Gunhee , Kim Yongju 
Published: September 2020

AbstractVarious biological systems rely on the supramolecular assembly of biomolecules through noncovalent bonds for performing sophisticated functions. In particular, cell membranes, which are 2D structures in biological systems, have various characteristics such as a large surface, flexibility, and molecule‐recognition ability. Supramolecular 2D materials based on biological systems provide a novel perspective for the development of functional 2D materials. The physical and chemical properties of 2D structures, attributed to their large surface area, can enhance the sensitivity of the detection of target molecules, molecular loading, and bioconjugation efficiency, suggesting the potential utility of functional 2D materials as candidates for biological systems. Although several types of studies on supramolecular 2D materials have been reported, supramolecular biofunctional 2D materials have not been reviewed previously. In this regard, the current advances in 2D material development using molecular assembly are discussed with respect to the rational design of self‐assembling aromatic amphiphiles, the formation of 2D structures, and the biological applications of functional 2D materials.
A Nickel‐Bisdiamine Porous Organic Polymer as Heterogeneous Chiral Catalyst for Asymmetric Michael Addition to Aliphatic Nitroalkenes
Authors: Buendia Mikkel B. , Kegnæs Søren , Kramer Søren 
Published: September 2020

AbstractWe report a polystyrene‐incorporated chiral nickel(II)‐bisdiamine complex, which is accessible on gram‐scale. This metal complex functions as a heterogeneous catalyst for the enantioselective Michael addition between malonates and aliphatic nitroalkenes, and it provides yields and enantioselectivities on par with homogeneous catalysts. Good functional group tolerance is reported for this reaction. Upon recycling, the catalyst achieves significantly higher TONs than previously reported. We demonstrate scalability to multigram‐scale, compatibility with continuous flow production (4.43 gram), and application to the synthesis of the blockbuster drug Pregabalin. Finally, a new tandem reaction is disclosed.magnified image
A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance
Authors: Zhang Li‐Zhen , Yang Jin‐E , Luo Yu‐Wei , Liu Feng‐Ting , Yuan Yun‐Fei , Zhuang Shi‐Mei 
Published: September 2020

AbstractAcetylation is a critical mechanism to modulate tumor‐suppressive activity of p53, but the causative roles of long non‐coding RNAs (lncRNAs) in p53 acetylation and their biological significance remain unexplored. Here, lncRNA LOC100294145 is discovered to be transactivated by p53 and is thus designated as lnc‐Ip53 for lncRNA induced by p53. Furthermore, lnc‐Ip53 impedes p53 acetylation by interacting with histone deacetylase 1 (HDAC1) and E1A binding protein p300 (p300) to prevent HDAC1 degradation and attenuate p300 activity, resulting in abrogation of p53 activity and subsequent cell proliferation and apoptosis resistance. Mouse xenograft models reveal that lnc‐Ip53 promotes tumor growth and chemoresistance in vivo, which is attenuated by an HDAC inhibitor. Silencing lnc‐Ip53 inhibits the growth of xenografts with wild‐type p53, but not those expressing acetylation‐resistant p53. Consistently, lnc‐Ip53 is upregulated in multiple cancer types, including hepatocellular carcinoma (HCC). High levels of lnc‐Ip53 is associated with low levels of acetylated p53 in human HCC and mouse xenografts, and is also correlated with poor survival of HCC patients. These findings identify a novel p53/lnc‐Ip53 negative feedback loop in cells and indicate that abnormal upregulation of lnc‐Ip53 represents an important mechanism to inhibit p53 acetylation/activity and thereby promote tumor growth and chemoresistance, which may be exploited for anticancer therapy.