bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRP78 effectively protect hypoxia/reperfusion‐induced myocardial apoptosis via promotion of the Nrf2/HO‐1 signaling pathway
Authors: Ji Heyu , Xiao Feng , Li Suobei , Wei Ruan , Yu Fei , Xu Junmei 
Published: July 2020

AbstractMyocardial infarction is a major cause of death worldwide. Despite our understanding of the pathophysiology of myocardial infarction and the therapeutic options for treatment have improved substantially, acute myocardial infarction remains a leading cause of morbidity and mortality. Recent findings revealed that GRP78 could protect myocardial cells against ischemia reperfusion injury‐induced apoptosis, but the exact function and molecular mechanism remains unclear. In this study, we aimed to explore the effects of GRP78 on hypoxia/reperfusion (H/R)‐induced cardiomyocyte injury. Intriguingly, we first observed that GRP78 overexpression significantly protected myocytes from H/R‐induced apoptosis. On mechanism, our work revealed that GRP78 protected myocardial cells from hypoxia/reperfusion‐induced apoptosis via the activation of the Nrf2/HO‐1 signaling pathway. We observed the enhanced expression of Nrf2/HO‐1 in GRP78 overexpressed H9c2 cell, while GRP78 deficiency dramatically antagonized the expression of Nrf2/HO‐1. Furthermore, we found that blocked the Nrf2/HO‐1 signaling by the HO‐1 inhibitor zinc protoporphyrin IX (Znpp) significantly retrieved H9c2 cells apoptosis that inhibited by GRP78 overexpression. Taken together, our findings revealed a new mechanism by which GRP78 alleviated H/R‐induced cardiomyocyte apoptosis in H9c2 cells via the promotion of the Nrf2/HO‐1 signaling pathway.
Fabrication techniques of biomimetic scaffolds in three‐dimensional cell culture: A review
Authors: Badekila Anjana K. , Kini Sudarshan , Jaiswal Amit K. 
Published: July 2020

AbstractIn the last four decades, several researchers worldwide have routinely and meticulously exercised cell culture experiments in two‐dimensional (2D) platforms. Using traditionally existing 2D models, the therapeutic efficacy of drugs has been inappropriately validated due to the failure in generating the precise therapeutic response. Fortunately, a 3D model addresses the foregoing limitations by recapitulating the in vivo environment. In this context, one has to contemplate the design of an appropriate scaffold for favoring the organization of cell microenvironment. Instituting pertinent model on the platter will pave way for a precise mimicking of in vivo conditions. It is because animal cells in scaffolds oblige spontaneous formation of 3D colonies that molecularly, phenotypically, and histologically resemble the native environment. The 3D culture provides insight into the biochemical aspects of cell–cell communication, plasticity, cell division, cytoskeletal reorganization, signaling mechanisms, differentiation, and cell death. Focusing on these criteria, this paper discusses in detail, the diversification of polymeric scaffolds based on their available resources. The paper also reviews the well‐founded and latest techniques of scaffold fabrication, and their applications pertaining to tissue engineering, drug screening, and tumor model development.
Understanding the degradation of the blue colour in the wall paintings of Ariadne's house (Pompeii, Italy) by non‐destructive techniques
Authors: Prieto‐Taboada Nagore , Fdez‐Ortiz de Vallejuelo Silvia , Santos Anne , Veneranda Marco , Castro Kepa , Maguregui Maite , Morillas Héctor , Arana Gorka , Martellone Alberta , de Nigris Bruno , Osanna Massimo , Madariaga Juan Manuel 
Published: July 2020

AbstractAriadne's house is in the Regio VII of the Archaeological Park of Pompeii (Italy). As it is exposed to external alteration agents (rainfall, water infiltration and atmospheric pollution), the mural paintings located in this important residence clearly show the effects of ongoing degradation processes. This is especially the case of Room 22 (also called the blue room), where the original blue decorations varied towards greyish green hues. In situ and laboratory spectroscopic analyses by means of non‐destructive X‐ray fluorescence, infrared and Raman spectroscopies identified the original pigments and the materials used in the conservation works. Looking in detail at the stratigraphic distribution of the original pigments, using Raman spectroscopy, an inner layer of Egyptian blue mixed with celadonite was detected under a layer of pure Egyptian blue. This discovery proves the presence of a more ancient painting below the one that can be observed today. Considering that celadonite was an inexpensive pigment (thus, probably used to reduce the costs of the paintings), this information strengthens the hypothesis that based on archaeological evidences, there is evidence of an evolution of the socio‐economic status of the ancient owners of the residence. In addition to that, Raman data also proved the occurrence of salt efflorescences; they provided insights about the compromised conservation state of the wall paintings, and they highlighted the action of atmospheric acid gases as an important factor.
The surface degradation of Baltic amber: The depth‐profiling analysis and its application to historical object
Authors: Rygula Anna , Klisińska‐Kopacz Anna , Krupska Paulina , Kuraś Elżbieta , del Hoyo‐Meléndez Julio M. 
Published: July 2020

AbstractA depth profile‐scanning study of an 18th‐century gun‐powder horn as well as reference Baltic amber samples was performed using a Raman confocal microscope equipped with a 785‐nm laser. It was found that spectra collected from the surface are different than those from the bulk. The main changes are observed in the 1,700–1,400 cm−1 range and are caused by degradation of the amber. The degraded layer was characterized mainly by an increase of the 1,615 cm−1 band ascribed to the ν(CC) characteristic of aromatic rings and a decrease of the 1,645 cm−1 band ascribed to the ν(CC) of nonconjugated structures. The degraded layer is estimated at 100–150 μm, where the spectra gradually resembled the spectrum of nondegraded amber. Analogous changes were observed both for the reference samples and for the abovementioned historical object. The observed spectral changes suggest that this technique could be utilized for studying the degradation of amber artifacts in museum collections.
Seventeen‐inch laser backlight in‐plane switching liquid crystal display with 8K, 120‐Hz driving, and BT.2020 color gamut
Authors: Komura Shinichi , Okuda Koichi , Onoda Ken , Kijima Hiroaki 
Published: July 2020

AbstractWe have developed a 17‐inch laser backlight in‐plane switching liquid crystal display satisfying the main BT.2020 specifications, which are 8K, 120‐Hz driving, and a BT.2020 wide color gamut. The color gamut of the developed in‐plane switching liquid crystal display covers 98% of the BT.2020 wide color gamut, thanks to a laser backlight and appropriate color filters. The liquid crystal response time of 5 ms, which is sufficient for 120‐Hz driving, is achieved by adapting a faster in‐plane switching liquid crystal display, namely, the short‐range lurch control in‐plane switching liquid crystal display.
Development of a detailed pyrolysis mechanism for C1–C4 hydrocarbons under a wide range of temperature and pressure
Authors: Cao Xiaomei , Gong Chunming , Liu Jianwen , Ma Huimin , Li Zerong , Wang Jingbo , Li Xiangyuan 
Published: July 2020

AbstractA model of core mechanism of hydrocarbon pyrolysis with good predictive ability is crucial to the development of active cooling technology for advanced aeroengines. In this work, a detailed core kinetic model of pyrolysis of C1–C4 hydrocarbon fuels is developed through the combination of a series of potential energy surfaces and validated against a series of experimental results. The kinetic model contains 103 species and 1290 reactions, and most of the kinetic and thermochemical parameters are compiled from recent highly accurate quantum chemical calculations without modification. The pressure‐dependent rate constants are considered for the dissociation/association reactions, isomerization reactions, and chemically activated reactions. Simulation results for various alkanes (methane, ethane, propane, n‐butane, isobutane), alkenes (ethylene, propene, 1‐butene, 2‐butene, isobutene, allene, 1,3‐butadiene), and alkynes (acetylene, propyne, vinylacetylene) indicate that the major product distributions at various temperatures (800‐2300 K) and pressures (0.8‐10 atm) can be predicted well by the developed core kinetic model. Thus, the developed pyrolysis mechanism for C1–C4 hydrocarbons can be used as a cornerstone to develop the pyrolysis mechanisms of larger hydrocarbon fuels and thus support the development of thermal management in advanced aeroengines.
The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses
Authors: Bassotti Gabrio , Marchegiani Andrea , Marconi Pierfrancesco , Fettucciari Katia 
Published: July 2020

AbstractClostridioides difficile infection (CDI) represents an important health problem worldwide, with significant morbidity and mortality. This infection has also high recurrence rates, whose pathophysiological grounds are still poorly understood. Based on our experiments in vitro with Clostridioides difficile toxin B and existing experimental and clinical evidence, we propose that primary CDI and relapses might be favored by a mechanism that involves the enhancement of the toxicity of toxin B by proinflammatory cytokines, tumor necrosis factor alpha, and interferon gamma on the enteric glial cells and their network in an environment characterized by a strong dysmicrobism.
Pseudomonas glycinae sp. nov. isolated from the soybean rhizosphere
Authors: Jia Jiayuan , Wang Xiaoqiang , Deng Peng , Ma Lin , Baird Sonya M. , Li Xiangdong , Lu Shi‐En 
Published: July 2020

AbstractStrains MS586T and MS82, which are aerobic, Gram‐negative, rod‐shaped, and polar‐flagellated bacteria, were isolated from the soybean rhizosphere in Mississippi. Taxonomic positions of MS586T and MS82 were determined using a polyphasic approach. 16S rRNA gene sequence analyses of the two strains showed high pairwise sequence similarities (>98%) to some Pseudomonas species. Analysis of the concatenated 16S rRNA, rpoB, rpoD, and gyrB gene sequences indicated that the strains belonging to the Pseudomonas koreensis subgroup (SG) shared the highest similarity with Pseudomonas kribbensis strain 46‐2T. Analyses of average nucleotide identity (ANI), genome‐to‐genome distance, delineated MS586T and MS82 from other species within the genus Pseudomonas. The predominant quinone system of the strain was ubiquinone 9 (Q‐9), and the DNA G+C content was 60.48 mol%. The major fatty acids were C16:0, C17:0 cyclo, and the summed features 3 and 8 consisting of C16:1ω7c/C16:1ω6c and C18:1ω7c/C18:1ω6c, respectively. The major polar lipids were phosphatidylglycerol, phosphatidylethanolamine, and diphosphatidylglycerol. Based on these data, it is proposed that strains MS586T and MS82 represent a novel species within the genus Pseudomonas. The proposed name for the new species is Pseudomonas glycinae, and the type strain is MS586T (accession NRRL B‐65441 = accession LMG 30275).
Genetic profile of non‐small cell lung cancer (NSCLC): A hospital‐based survey in Jinhua
Authors: Chen Xianguo , Xu Bo , Li Qiang , Xu Xiaoyi , Li Xianshuai , You Xia , Yu Zhaonan 
Published: July 2020

AbstractBackgroundWe describe the clinical features, genetic profile, and their correlation in NSCLC patients.MethodsA total of 256 Chinese patients with NSCLC were enrolled in this study. NGS‐based genomic profiling of major lung cancer‐related genes was performed on formalin‐fixed paraffin‐embedded tumor samples.ResultsOf 256 patients with NSCLC, 219 were adenocarcinoma and most of them were in the early stage. Among patients, 63.3% patients have more than two gene mutations. By analyzing variant allele frequency (VAF), we found that the median VAF has significant differences between squamous cell carcinoma and adenocarcinoma, as well as early stage and advanced stage. The frequency of mutations in EGFR, MET, and RET were significantly higher in nonsmokers than in smokers. Besides, Pearson correlation analysis found that ALK, BRAF, and MET mutations had a strong correlation with age. Notably, higher frequencies of ALK and BRAF alterations were associated with younger age, while more frequent MET mutations appear in the patients at age 55 or older.ConclusionMore unique features of cancer driver genes in Chinese NSCLC were identified by next‐generation sequencing. These findings highlighted that it is necessary to carry out targeted detection according to different clinical features for NSCLC.
On accounting for screen resolution in adaptive video streaming: QoE‐driven bandwidth sharing framework
Authors: Belmoukadam Othmane , Jawad Khokhar Muhammad , Barakat Chadi 
Published: July 2020

SummaryScreen resolution along with network conditions are main objective factors impacting the user experience, in particular for video streaming applications. User terminals on their side feature more and more advanced characteristics resulting in different network requirements for good visual experience. Previous studies tried to link mean opinion score (MOS) to video bitrate for different screen types (e.g., Common Intermediate Format [CIF], Quarter Common Intermediate Format [QCIF], and High Definition [HD]). We leverage such studies and formulate a Quality of Experience (QoE)‐driven resource allocation problem to pinpoint the optimal bandwidth allocation that maximizes the QoE over all users of a network service provider located behind the same bottleneck link, while accounting for the characteristics of the screens they use for video playout. For our optimization problem, QoE functions are built using curve fitting on datasets capturing the relationship between MOS, screen characteristics, and bandwidth requirements. We propose a simple heuristic based on Lagrangian relaxation and Karush Kuhn Tucker (KKT) conditions to efficiently solve the optimization problem. Our numerical simulations show that the proposed heuristic is able to increase overall QoE up to 20% compared to an allocation with a TCP look‐alike strategy implementing max‐min fairness.
Re‐analysing the Baining: TheMytho‐Poeticsof Race, Gender and Art
Authors: Lattas Andrew 
Published: July 2020

ABSTRACTThis article criticises primitivist caricatures of the Baining in Melanesia as a society that lacks exegesis, symbolic logics, religion, structures of power and control, and even an interest in play. The mytho‐poetics of gender and procreation in Mali Baining society are documented by focusing on how art and sexuality are traced onto each other. The formative power of painting, barkcloth, dancing masks, netbags and music are merged with the formative power of women. Art and sexuality are made to inform each other's generative potential, and even each other's aesthetic charm. These fertile mytho‐poetic practices also underpin Mali political practices. Mali indigenous identity is celebrated as local control over the original powers of creation, which continue to reside in the earth, in the local landscape and, above all, in that which underpins all creation, women's procreative bodies with their creative potential to bring forth something new. The Mali localise creative processes so as to empower and revalue themselves within a culture of resistance to the hegemony of colonialism, modernity, settlers and regional ethnic elites.
How is childhood maltreatment linked to benign envy/malicious envy? The mediating role of self‐esteem, authentic pride and hubristic pride
Authors: Li Qingyin , Xiang Yanhui 
Published: July 2020

AbstractObjectiveThis study aimed to investigate the role of pride and self‐esteem in the relationship between childhood maltreatment and benign envy/malicious envy in Chinese college students.MethodsOne thousand fifty‐one Chinese college students completed the Childhood Trauma Questionnaire, the Rosenberg Self‐Esteem Scale, the Authentic and Hubristic Pride‐Proneness Scale and the Benign and Malicious Envy Scale, and the significance test of mediating variables was performed.ResultsSelf‐esteem and hubristic pride independently mediated the relationship between childhood maltreatment and benign envy/malicious envy, authentic pride only played a mediating role in the relationship between childhood maltreatment and benign envy. More importantly, the model indicated that childhood maltreatment could influence benign envy/malicious envy through the chain mediating path of ‘authentic pride–self‐esteem’ and ‘hubristic pride–self‐esteem’.ConclusionsAuthentic pride, hubristic pride and self‐esteem might be the possible mechanisms through which childhood maltreatment influences benign envy/malicious envy in adulthood. This study provides insights into the role of pride and self‐esteem in the childhood maltreatment–benign (malicious) envy link from the perspective of the learned helplessness theory. © 2020 John Wiley & Sons, Ltd.
Nonthermal plasma as part of a novel strategy for vaccination
Authors: Mohamed Hager , Esposito Rita A. , Kutzler Michele A. , Wigdahl Brian , Krebs Fred C. , Miller Vandana 
Published: July 2020

AbstractVaccination has been one of the most effective health intervention mechanisms to reduce morbidity and mortality associated with infectious diseases. Vaccines stimulate the body's protective immune responses through controlled exposure to modified versions of pathogens that establish immunological memory. However, only a few diseases have effective vaccines. The biological effects of nonthermal plasma on cells suggest that plasma could play an important role in improving efficacy of existing vaccines and overcoming some of the limitations and challenges with current vaccination strategies. This review summarizes the opportunities for nonthermal plasma for immunization and therapeutic purposes.
Expanding tropical forest monitoring into Dry Forests: The DRYFLOR protocol for permanent plots
Authors: Moonlight Peter W. , Banda‐R Karina , Phillips Oliver L. , Dexter Kyle G. , Pennington R. Toby , Baker Tim R. , C. de Lima Haroldo , Fajardo Laurie , González‐M. Roy , Linares‐Palomino Reynaldo , Lloyd Jon , Nascimento Marcelo , Prado Darién , Quintana Catalina , Riina Ricarda , Rodríguez M. Gina M. , Maria Villela Dora , Aquino Ana Carla M. M. , Arroyo Luzmila , Bezerra Cidney , Tadeu Brunello Alexandre , Brienen Roel J. W. , Cardoso Domingos , Chao Kuo‐Jung , Cotta Coutinho Ítalo Antônio , Cunha John , Domingues Tomas , do Espírito Santo Mário Marcos , Feldpausch Ted R. , Ferreira Fernandes Moabe , Goodwin Zoë A. , Jiménez Eliana María , Levesley Aurora , Lopez‐Toledo Leonel , Marimon Beatriz , Miatto Raquel C. , Mizushima Marcelo , Monteagudo Abel , Soelma Beserra de Moura Magna , Murakami Alejandro , Neves Danilo , Nicora Chequín Renata , César de Sousa Oliveira Tony , Almeida de Oliveira Edmar , P. de Queiroz Luciano , Pilon Alan , Marques Ramos Desirée , Reynel Carlos , Rodrigues Priscyla M. S. , Santos Rubens , Särkinen Tiina , Fernando da Silva Valdemir , Souza Rodolfo M. S. , Vasquez Rodolfo , Veenendaal Elmar 
Published: July 2020

Societal Impact StatementUnderstanding of tropical forests has been revolutionized by monitoring in permanent plots. Data from global plot networks have transformed our knowledge of forests’ diversity, function, contribution to global biogeochemical cycles, and sensitivity to climate change. Monitoring has thus far been concentrated in rain forests. Despite increasing appreciation of their threatened status, biodiversity, and importance to the global carbon cycle, monitoring in tropical dry forests is still in its infancy. We provide a protocol for permanent monitoring plots in tropical dry forests. Expanding monitoring into dry biomes is critical for overcoming the linked challenges of climate change, land use change, and the biodiversity crisis.
Randomized trial of lung hyperinflation therapy in children with congenital muscular dystrophy
Authors: Sawnani Hemant , Mayer Oscar H. , Modi Avani C. , Pascoe John E. , McConnell Keith , McDonough Joseph M. , Rutkowski Anne M. , Hossain Md Monir , Szczesniak Rhonda , Tadesse Dawit G. , Schuler Christine L. , Amin Raouf 
Published: July 2020

AbstractObjectiveRespiratory compromise in congenital muscular dystrophy (CMD) occurs, in part, from chest wall contractures. Passive stretch with hyperinsufflation therapy could reduce related costo‐vertebral joint contractures. We sought to examine the impact of hyperinsufflation use on lung function and quality of life in children with CMD.Study DesignWe conducted a randomized controlled trial on hyperinsufflation therapy in children with CMD at two centers. An individualized hyperinsufflation regimen of 15 minutes twice daily using a cough assist device over a 12 months period was prescribed. We measured lung function, quality of life, and adherence. To demonstrate reproducibility, pulmonary function was measured twice on the same day. A mixed‐effects regression model adjusting for confounders was used to assess the effects of hyperinsufflation.ResultsWe enrolled 34 participants in the study; 31 completed the trial (n = 17 treatment group and n = 14 controls). Participants in the treatment group demonstrated a relative gain in lung volume measured at 4 and 8 months, but not at 12 months. The control group required increases in the maximum insufflation pressures to achieve maximum lung volumes while the treatment group did not. Adherence was best early in the study, peaking at the first visit and decreasing at subsequent visits. Caregiver‐reported quality of life was higher in the treatment group.ConclusionHyperinsufflation therapy is effective in increasing and sustaining lung volume over time. Adherence, however, was inconsistent and difficult to maintain. Further research should determine if improved adherence leads to sustained benefits of hyperinsufflation.
Promoting emotional wellness in children with cystic fibrosis, Part I: Child and family resilience
Authors: Prieur Mary G. , Christon Lillian M. , Mueller Amy , Smith Beth A. , Georgiopoulos Anna M. , Boat Thomas F. , Filigno Stephanie S. 
Published: July 2020

AbstractAttention should be given to individual and family well‐being from a child's first interaction with the medical team and continuing throughout development, especially for families who experience chronic illnesses, such as cystic fibrosis (CF). While much attention has been given to the mental health of people with CF 12 years and older, this paper explores various areas for CF teams to assess and provide additional resources during the first 12 years of a child's life to promote child and family wellness. In this paper, we discuss parental mental health, social determinants of health, adherence/self‐care, nutrition, attention to family lifestyle factors, engagement with school and peers, and modulator therapy for this age group of people with CF. This is the first of two companion papers which examines emotional wellness of children during the early years. The second paper examines mental health assessment and intervention for children under 12. Both encourage teams to strive to promote optimal child and family emotional health and wellness, emphasizing holistic health promotion and prevention, early identification, and intervention.