bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
Authors: Riedmaier Arian Emami , DeMent Kevin , Huckle James , Bransford Phil , Stillhart Cordula , Lloyd Richard , Alluri Ravindra , Basu Sumit , Chen Yuan , Dhamankar Varsha , Dodd Stephanie , Kulkarni Priyanka , Olivares-Morales Andrés , Peng Chi-Chi , Pepin Xavier , Ren Xiaojun , Tran Thuy , Tistaert Christophe , Heimbach Tycho , Kesisoglou Filippos , Wagner Christian , Parrott Neil 
Published: September 2020

AbstractThe effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinically relevant food effect. Here, the predictive performance of physiologically based pharmacokinetic (PBPK) food effect models was assessed via de novo mechanistic absorption models for 30 compounds using controlled, pre-defined in vitro, and modeling methodology. Compounds for which absorption was known to be limited by intestinal transporters were excluded in this analysis. A decision tree for model verification and optimization was followed, leading to high, moderate, or low food effect prediction confidence. High (within 0.8- to 1.25-fold) to moderate confidence (within 0.5- to 2-fold) was achieved for most of the compounds (15 and 8, respectively). While for 7 compounds, prediction confidence was found to be low (> 2-fold). There was no clear difference in prediction success for positive or negative food effects and no clear relationship to the BCS category of tested drug molecules. However, an association could be demonstrated when the food effect was mainly related to changes in the gastrointestinal luminal fluids or physiology, including fluid volume, motility, pH, micellar entrapment, and bile salts. Considering these findings, it is recommended that appropriately verified mechanistic PBPK modeling can be leveraged with high to moderate confidence as a key approach to predicting potential food effect, especially related to mechanisms highlighted here.
Prehospital unfractionated heparin prior to primary PCI
Authors: Sealy Madison , Stuart Olivia , Ebbs Phillip 
Published: September 2020

Introduction: Unfractionated heparin is an anticoagulant used by some, but not all, ambulance services in the treatment of patients who will undergo primary percutaneous coronary intervention (PPCI) due to ST-elevation myocardial infarction (STEMI). Aims: The purpose of this study is to review the effectiveness and safety of prehospital unfractionated heparin administration to STEMI patients prior to PPCI, and to consider whether this drug should be more widely used for these purposes across international ambulance services. Methods: A literature search was conducted to identify articles relevant to prehospital unfractionated heparin (UFH) administration prior to PPCI. Eighteen journal articles and ten clinical practice guideline compendiums from international ambulance services were selected for this review. Results: The reviewed literature unequivocally demonstrates that early anticoagulant administration is safe, effective and highly appropriate for STEMI patients who subsequently undergo PPCI. There are disagreements, however, about whether UFH is the more optimal anticoagulant when compared with enoxaparin. Conclusion: This study finds that anticoagulants—such as unfractionated heparin or, in some jurisdictions, enoxaparin—should be strongly considered as a standard feature of prehospital treatment regimens for STEMI patients who will subsequently undergo PPCI.
CULTIVATING ENTREPRENEURIAL VALUES TO IMPROVE SEVERAL ASPECTS OF EARLY CHILDHOOD DEVELOPMENT: THE CASE STUDY IN KHALIFAH KINDERGARTEN YOGYAKARTA
Authors: AH Nurkamelia Mukhtar , Munip Abdul 
Published: September 2020

The entrepreneurial values such as independent, creativity, risk-taking ability, and responsibility play an important role in directing early childhood development, especially in the aspect of social-emotional, language, and cognitive. Khalifah kindergarten which is based on entrepreneurship, support the life skills development of children with several of excellent programs for example Market Day. This study is intended to know the reason of Khalifah Kindergarten in applying entrepreneurship program, the process and impact of the program on the aspects of early childhood development. The findings of this study are: first, Khalifah Kindergarten wants to achieve its mission in integrating entrepreneurial values in all aspects of early childhood development by introducing them to become Muslims entrepreneur. Second, the process of increasing the entrepreneurial values is implemented through Beyond Centre and Circle Time (BCCT) learning system, entrepreneurship activities such as market day, cooking classes, field trips, angklung music as an extracurricular activity, and habituation through continuous interviews with the students. Third, the impact of entrepreneurial values can be proved in several aspects of development. In the social-emotional aspect, the children have empathy for others. In the cognitive aspect, the children have creative thinking. In an aspect of linguistic development, they become communicative, and in the physical-motor aspect, the children have the high spirit to produce a work.
Upaya Meningkatkan Jaminan Perlindungan Pekerja Migran Indonesia
Authors: Solechan Solechan , Utami Tri Rahayu , Azhar Muhamad 
Published: September 2020

Berdasarkan Pasal 1 Angka 3 Undang-Undang Nomor 18 Tahun 2017 tentang Perlindungan Pekerja Migran Indonesia, Pekerja Migran Indonesia adalah setiap warga negara Indonesia yang akan, sedang, atau telah melakukan pekerjaan dengan menerima upah di luar wilayah Republik Indonesia. Human Capital Index (HCI) menempatkan Indonesia berada pada peringkat ke-87 atau urutan ke-6 di Asia Tenggara sehingga berpengaruh terhadap kualitas Pekerja Migran Indonesia. HCI Indoneisa yang rendah tentu perlu ditingkatkan untuk meningkatkan pula daya saing dan kualitas Pekerja Migran Indonesia yang akan menunjang daya tawar Pekerja Migran Indonesia di tingkat global. Penelitian ini dilakukan untuk mengetahui urgensi diperlukannya Peningkatan Posisi Daya Tawar Sebagai Upaya Meningkatkan Jaminan Perlindungan Pekerja Migran Indonesia Oleh Pemerintah. Kata Kunci: Pekerja Migran Indonesia, Daya Tawar, Kualitas. Abstract Based on Article 1 Number 3 of Law Number 18 Year 2017 concerning the Protection of Indonesian Migrant Workers, Indonesian Migrant Workers are any Indonesian citizens who will, are or have done work by receiving wages outside the territory of the Republic of Indonesia. The Human Capital Index (HCI) ranks Indonesia at 87th or 6th in Southeast Asia so that it affects the quality of Indonesian Migrant Workers. The low Indonesian HCI certainly needs to be improved to improve the competitiveness and quality of Indonesian Migrant Workers who will support the bargaining power of Indonesian Migrant Workers at the global level. This research was conducted to determine the urgency of the need to increase the bargaining power position as an effort to improve the guarantee of protection of Indonesian migrant workers by the government. Keyword: Indonesian Migrant Workers, Bargaining Power, Quality.
Pertanggungjawaban Pejabat Pemerintahan Sebagai Akibat Penyalahgunaan Wewenang Yang Menimbulkan Kerugian Negara
Authors: Juliani Henny 
Published: September 2020

This research is aimed to find out legal basis of Government Officer responsibility as consequence of authority abused that cause state financial lost. This research used normative juridical method by using analytical descritive approach. This research found out that Government Officers (including treasurers, non treasurer public servants, or other officers), could be penalized to fine if there is mal-administration in their decission or actions that cause state financial lost. The fine will become personal responisbility if there is abuse of power. Otherwise, state financial lost will be compesate to government institutions as official responsibilitynif there is not any abuse of power. Government officers who defined to compensate government financial lost can be penalized with administrative penalty and/or criminal penalty. Criminal penalty will not release compensation obligation. Abstrak Penelitian ini bertujuan untuk mengetahui pertanggungjawaban Pejabat Pemerintahan sebagai akibat penyalahgunaan wewenang yang menimbulkan kerugian keuangan negara berdasarkan peraturan perundang-undangan. Metoda penelitian yang digunakan adalah yuridis normatif dengan spesifikasi penelitian deskriptif analitis. Dari hasil penelitian dapat diketahui bahwa Pejabat Pemerintahan (termasuk di dalamnya bendahara, pegawai negeri bukan bendahara, atau pejabat lain), dapat dikenai tuntutan ganti kerugian negara/daerah jika Keputusan dan/atau Tindakan yang ditetapkan dan/atau dilakukan terdapat kesalahan administratif yang menimbulkan kerugian keuangan negara. Pengembalian kerugian negara dibebankan kepada Pejabat Pemerintahan sebagai tanggung jawab pribadi apabila ada unsur penyalahgunaan wewenang. Sedangkan pengembalian kerugian negara dibebankan kepada Badan Pemerintahan sebagai tanggung jawab jabatan apabila terjadi bukan karena adanya unsur penyalahgunaan wewenang. Oleh karena itu Pejabat Pemerintahan yang telah ditetapkan untuk mengganti kerugian negara/daerah dapat dikenai sanksi administratif dan/atau sanksi pidana. Putusan pidana tidak membebaskan dari tuntutan ganti rugi.
Rules and Policies Related with Good Governance When Corona Virus 2019 (COVID19) Pandemic
Authors: Solechan Solechan 
Published: September 2020

The policy made by the government in relation to COVID 19, became a quite heated discussion among the community. In fact, many observers are questioning the policy. At present, the government is faced with two choices, namely maintaining the lives of citizens or maintaining the economy. Policies taken by the government must be based on the principle of good governance. The principle of good governance is an important principle in making policy. One of the principles in good governance is the principle of community participation. Through this research, we will see how community participation is related to policies made by the government, moreover, public awareness is still lacking related to government policies to deal with this pandemic. Keywords: Government, principle, community participation Abstrak Kebijakan yang dibuat oleh pemerintah terkait dengan COVID 19, menjadi pembahasan yang cukup hangat dikalangan masyarakat. Bahkan, para pengamat banyak yang mempersoalkan kebijakan tersebut. Saat ini, pemerintah dihadapkan dengan dua pilihan, yaitu mempertahankan nyawa warga negara atau mempertahankan perekonomian. Kebijakan yang diambil oleh pemerintah, harus didasari oleh prinsip good governance. Prinsip good governance ini menjadi prinsip yang penting dalam mengambil kebijakan. Salah satu prinsip yang ada di good governance adalah prinsip partisipasi masyarakat. Melalui penelitian ini, kita akan melihat bagaimana partisipasi masyarakat terkait kebijakan yang dibuat oleh pemerintah, terlebih lagi, kesadaran masyarakat yang masih kurang terkait dengan kebijakan pemerintah untuk menangani pandemi ini. Keywords: Pemerintah, Prinsip, Partisipasi Masyarakat
Larangan Ultra Vires (Exces De Pouvoir) dalam Tindakan Pemerintahan (Studi Komparasi Konsep antara Sistem Hukum Anglo Saxon dan Sistem Hukum Kontinental)
Authors: Susanto Sri Nurhari 
Published: September 2020

This research aims to determine the use of authority by government agencies is legality. Specifically, to find out more about the prohibition of Ultra Vires (Exces De Pouvoir) in Government Actions (Comparative Study of Concepts between the Anglo Saxon Law System and the Continental Legal System). The results of the study indicate that First, the form of government agency action prohibition in the form of excès de pouvoir (ultra vires), both in the Anglo Saxon legal system (Britain, USA, Australia, etc.) and Continental especially France includes also the prohibition of abuse of authority (abuse of power, detournement de pouvoir). Second, the Prohibition of abuse of authority (detournement de pouvoir) in France has been developed into 3 (three) variants, namely the Administrative Agency has the purpose / aims to achieve goals that are entirely other than the public interest, and as a personal goal. Keywords: Prohibition of Ultra Vires, Government Actions, Legal System. Abstrak Penelitian inimbertujuan untuk mengetahui Larangan Ultra Vires (Exces De Pouvoir) dalam Tindakan Pemerintahan (Studi Komparasi Konsep Antara Sistem Hukum Anglo Saxon Dan Sistem Hukum Kontinental). Hasil penelitian menjukan bahwa Pertama, Bentuk larangan tindakan badan pemerintah yang berupa excès de pouvoir (ultra vires), baik dalam sistem hukum Anglo Saxon (Inggris, USA, Australia, dll) maupun Kontinental khususnya Prancis meliputi juga larangan penyalahgunaan wewenang (abuse of power, detournement de pouvoir). Kedua, Larangan penyalahgunaan wewenang (detournement de pouvoir) di Prancis telah dikembangkan ke dalam 3 (tiga) varian, yaitu Badan Administrasi memiliki tujuan/bertujuan untuk mencapai tujuan yang sepenuhnya selain bagi kepentingan umum, dan sebagai tujuan pribadi. Kata Kunci: Larangan Ultra Vires, Tindakan Pemerintahan, Sistem Hukum.
Development of Chemo-Entrepreneurship Oriented Learning Design Based on Green Chemistry
Authors: Setyaningsih Umi , Sumarti Sri Susilogati , Sudarmin Sudarmin 
Published: September 2020

This study aims to produce a valid and effective learning device for chemo-entrepreneurship-based projects that are valid and positive student responses. This research includes development research adopted from Thiagarajan, a modified 4D model. The 4-D model consists of four stages of development, namely Define , Design, Develop , and Disseminate, Disseminate stage is not done because the Develop phase has produced a valid learning device. The validity assessment of learning devices was carried out by four experts. Instrument for assessing learning devices are syllabus components, lesson plan, teaching materials, project work sheets. The effectiveness of learning devices is seen from improving student learning outcomes. Based on the results of the analysis obtained a validity value of 3,59 (88,5%) with a very good category. Entrepreneurial interest in the extensive trial shows that the results of the paired sample t-test obtained a tcount = 19,981 and t table = 2,03. Tcount> t table which means there is a significant increase in student interest. Based on the results of the assessment, the learning devices of the chemo-entrepreneurship-based green chemistry-based clean project can be said to be valid and effective for learning.
Development of Digital Pocketbook About Fungi in Mount Merbabu National Park as the Supplement of Teaching Material at Senior High School
Authors: Hafizhasando Ramajid , Saptono Sigit , Parmin Parmin , Rahayuningsih Margareta 
Published: September 2020

The challenge of improving the 21st-century education quality in the industrial revolution 4.0 erais that graduates are expected to have theknowledge skills, abilities in the field of technology, information media, and learning innovation skills for life and career skills. This research was aimed to develop a digital fungi pocketbook in Mount Merbabu National Park to improve student learning outcomes. This research was a Research and Development (R&D) study, which used the Gall, Gall, and Borg model. The data analysis techniques used were descriptive data analysis related to the validity of responses from users, while the N-gain test was used to determine the product's effectiveness. The results showed (1) the digital pocketbook developed had very valid criteria regarding aspects of media, language, and material (2) students and teachers gave responses to the digital pocketbook used in learning with very valid response criteria (3) the value of learning outcomes students showed improvement with moderate N-Gain scores. Thus, the digital pocketbook that was developed can be used as an additional learning source in learning Natural Sciences (Biology) in the face of the 21st century and the industrial revolution 4.0.
Estudo da distribuição de dose de feixes clínicos de elétrons em meios heterogêneos
Authors: Aguirre Eder , De Almeida Carlos Eduardo , David Mariano , Venencia Daniel 
Published: September 2020

Este trabalho estuda o comportamento da distribuição de dose de feixes de elétrons de uso clínico utilizando o método Monte Carlo, através do código PENELOPE na presença de heterogeneidades. O método Monte Carlo é considerado em diferentes áreas das ciências exatas, como um importante método para simulações e cálculos na área de física médica. O primeiro objetivo do trabalho é de validar as simulações através da comparação com as distribuições de dose medidas ao longo do eixo central (curvas de PDP) de feixes de elétrons de uso clínico. Uma primeira aproximação é feita considerando o feixe de elétrons monoenergético para construir os espectros que melhor reproduzam parâmetros relevantes que caracterizam, por exemplo, as curvas de PDP (Porcentagem de Dose na Profundidade). Os espectros foram modelados de forma a reproduzir com boa concordância as curvas de PDP experimentais tendo sido usado como critério que a qualidade do feixe e o alcance entre os valores medidos e os simulados ficassem com um nível de concordância de 1mm. O segundo visou simular a inserção de materiais com diferentes densidades, e o efeito nas curvas de PDP e isodose. As heterogeneidades simuladas apresentaram resultados que variam de superdosagem a subdosagem que tem que ser levados em consideração ao momento de planejar e administrar a dose ao paciente.
The method of finite spheres in acoustic wave propagation through nonhomogeneous media: Inf-sup stability conditions
Authors: Nicomedes Williams L. , Bathe Klaus-Jürgen , Moreira Fernando J. S. , Mesquita Renato C. 
Published: September 2020

When the method of finite spheres is used for the solution of time-harmonic acoustic wave propagation problems in nonhomogeneous media, a mixed (or saddle-point) formulation is obtained in which the unknowns are the pressure fields and the Lagrange multiplier fields defined at the interfaces between the regions with distinct material properties. Then certain inf-sup conditions must be satisfied by the discretized spaces in order for the finite-dimensional problems to be well-posed. We discuss in this paper the analysis and use of these conditions. Since the conditions involve norms of functionals in fractional Sobolev spaces, we derive ‘stronger’ conditions that are simpler in form. These new conditions pave the way for the inf-sup testing, a tool for assessing the stability of the discretized problems.
Misattributions and misnomers in mechanics: Why they matter in the search for insight and precision of thought
Authors: Reddy J. N. , Srinivasa Arun R. 
Published: September 2020

The purpose of this article is to bring some examples of misattributes (i.e., theories and models that bear some one’s name while the idea belongs to someone else) and misnomers (i.e., words or phrases that are either incorrect or inaccurate) to the attention of the colleagues in the field, and correct them so that these incorrect phrases and attributions and misnomers are not repeated in the future writings. In the process, we also discuss the purpose of a literature reviews and the need for precision of thought in naming ideas or concepts. It is hoped that people will be careful and precise in using the words, names, and phrases correctly (since after all, these represent ideas that need to be communicated) and not propagate inaccurate information in the literature. The discussion presented is restricted to mostly structural and computational mechanics.
Pemanfaatan Media Sosial dalam Pemasaran Produk UMKM di Kelurahan Sidokumpul, Kabupaten Gresik
Authors: Abidin Achmad Zainal , Zendo Azhari Thareq , Naufal Esfandiar Wildan , Nuryaningrum Nafila , Farah Dhilah Syifana Anisah , Cahyaningrum Indah 
Published: September 2020

This research discusses how the use of social media in marketing UMKM products in Sidokumpul Village, Gresik District, Gresik Regency. The research objective is to introduce UMKM products to the wider community in order to get a bigger market potential. This research method is qualitative by using phenomenological approach. The research result is, the use of social media provides good prospects for increasing the sales of UMKM products in Sidokumpul Village, Gresik District, Gresik Regency which is experiencing the impact of the COVID-19 pandemic. This is because the digital marketing system provides an online buying and selling platform, in order to facilitate the ordering and purchasing process. So that buyers can interact with UMKM owners to make transactions directly
Komunikasi Politik Kiai Dalam Pemilihan Umum Tahun 2019
Authors: Mushthofa Misyuniarto Khoirul 
Published: September 2020

This study examines the political communication strategy carried out by Kiai as a boarding school caretaker in the General Election. The purpose of this study is to describe the political communication strategy carried out by Kiai Syafik Rofi'i, caretaker of the Salafiyah Syafi'iyah Islamic Boarding School in Bangkalan Regency, East Java Province in the 2019 General Election.
This study uses a qualitative descriptive method with a case study approach. The results showed that the political communication strategy being implemented was political negotiation among kiai in Islamic boarding schools in Bangkalan Regency. In addition, political communication uses the strategy of a campaign winning team or success team, and also uses the media as a channel for delivering messages to provide understanding and influence public opinion.
Introduction to the GaLA Conf 2019 Special Issue
Authors: Liapis Antonios , Yannakakis Georgios N. , Gentile Manuel , Ninaus Manuel 
Published: September 2020

It is a great pleasure for us to introduce this issue of the IJSG, which is dedicated to the Games and Learning Alliance Conference (GaLA Conf) that was held in Athens, November 27-29, 2019. Almost 70 participants converged in this beautiful, historic city in order to share knowledge and experiences related to serious games and gamification, their techniques and their application.
A number of the best conference papers were selected, and the authors were invited to extend their paper with at least one-third new content, and to submit their paper to IJSG for a regular peer-review process. This issue contains three of the resulting articles, which gives an overview of the rich field of serious games.
Del activismo docente, el saber pedagógico del maestro y su impacto en la realización profesional de sus estudiantes sordos
Authors: Bolaños-Motta José Ignacio , Casallas-Forero Elizabeth , Sabogal-Gámez Viviana Jazmín 
Published: September 2020

El presente estudio tuvo como objetivo exponer la existencia de una relación vinculante entre el éxito profesional de un grupo de diez docentes sordos de diversas ciudades del país, y las personas que fueron sus maestros durante su vida escolar y universitaria. Dentro del estudio se tomaron algunas consideraciones teóricas, respecto al tema del éxito profesional, además de algunas bibliografías referentes al tema de la discapacidad auditiva. Se siguió el método biográfico narrativo, para lo cual se usaron herramientas como la entrevista a profundidad y la cartografía social. En el apartado de los resultados se presentan dos categorías: 1) el activismo docente en los derechos de las personas en condición de discapacidad y 2) La importancia del saber pedagógico en el campo de la discapacidad. Como conclusión se da a conocer la existencia de una base para el buen desarrollo del educador del campo de la discapacidad, pues los maestros de las personas sordas que hicieron parte de este estudio contaban con excelentes cualidades humanas y profesionales.