bluuebunny/crossref_metadata_2025_split huggingface dataset:
O3B.6 The economic burden of work-related asbestos exposure
Authors: Tompa Emile , Kalcevich Christina , McLeod Christopher , Lebeau Martin , Song Chaojie , Kim Joanne , Demers Paul 
Published: May 2020

The objective of this study was to estimate the economic burden of lung cancer and mesothelioma due to occupational and paraoccupational asbestos exposure in Canada.We estimated the lifetime cost of newly diagnosed lung cancer and mesothelioma cases associated with occupational and para-occupational asbestos exposure for calendar year 2011 based on the societal perspective. The key cost components considered were healthcare costs, productivity and output costs, and quality of life costs.There were 427 cases of newly diagnosed mesothelioma cases and 1904 lung cancer cases attributable to asbestos exposure in our reference year—calendar year 2011—for a total of 2331 cases. Our estimate of the economic burden is $C831 million in direct and indirect costs for newly identified cases of mesothelioma and lung cancer and $C1.5 billion in quality of life costs based on a value of $C100,000 per quality-adjusted life year. This amounts to $C356,429 and $C652,369 per case, respectively.The economic burden of lung cancer and mesothelioma associated with occupational and para-occupational asbestos exposure is substantial. The estimate identified is for 2331 newly diagnosed, occupational and para-occupational exposure cases in 2011, so it is only a portion of the burden of existing cases in that year. Our findings provide important information for policy decision makers for priority setting, in particular the merits of banning the mining of asbestos and use of products containing asbestos in countries where they are still allowed and also the merits of asbestos removal in older buildings with asbestos insulation.
O1A.2 Exposure to benzimidazole fungicides in agriculture and non-hodgkin lymphomas, overall and by subtypes, in the AGRIculture and CANcer (AGRICAN) cohort
Authors: Busson Amandine , Tual Séverine , Boulanger Mathilde , Renier Marine , Pons Romain , Piel Clément , Pouchieu Camille , Lecluse Yannick , Perrier Stéphanie , Levêque-Morlais Noémie , AGRICAN- GROUP , Guizard Anne-Valérie , Monnereau Alain , Baldi Isabelle , Lebailly Pierre 
Published: May 2020

PurposeIncreased risks of Non-Hodgkin’s Lymphomas (NHLs) have been reported among farmers in several meta-analyses, with exposure to pesticides as the main explanation. Few studies investigated associations by NHL subtypes and considering specific pesticides. From the French agricultural cohort AGRICAN, we assessed the role of benzimidazole fungicides use on NHL risk, overall and for multiple myeloma (MM), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL-SLL) and Diffuse Large B-cell Lymphoma (DLBCL).MethodsNearly 1 82 000 participants affiliated in a health assurance system reported in the enrollment questionnaire (2005–2007) lifetime pesticide use with start and end year on 13 crops and were followed until 2013. Using the crop-exposure matrix PESTIMAT, associations between NHLs and benzimidazole fungicides exposure (overall and for benomyl, carbendazim, fenzaflore, thiabendazole and thiophanate methyl) were estimated using Cox models.ResultsAfter exclusion of prevalent cases, individuals with incomplete agricultural profession history data or a zero tracking period, 1,133 NHL incident cases were identified from cancer registries (269 MM, 244 CLL-SLL, 190 DLBCL). Nearly 20% of participants were considered exposed (median duration from 7 to 20 years according to active ingredient). Increased NHL risk was observed with exposure to benzimidazole, overall, on any crops (NHL: HR=1.13, 95%CI=0.94–1.37, 150 cases, no duration relationship). Moreover, borderline positive associations were reported on specific crops: wheat/barley (NHL: HR=1.23, CLL-SLL: HR=1.42), beets (DLBCL, HR=2.19) and rape (DLBCL, 2.32). Significant increased risks were reported with MM for use of thiophanate-methyl on wheat/barley (HR=3.46, 23 exposed cases, no duration relationship) and with DLBCL for all 4 benzimidazole used on beets (HR from 2.34 to 2.57 and for the 2 used on rape (HR=2.39 and 2.46), although based on respectively 7 and 6 cases.ConclusionThese findings suggest positive associations between incidence of specific NHL subtypes, and exposure to benzimidazole as a chemical family or specific ingredients in this family.
O3D.4 Innovative approaches to data acquisition, standardization, pooling and analyses of occupational health information
Authors: Vermeulen Roel 
Published: May 2020

Occupation and employment is a major determinant of health and healthy aging. Despite the temporal increase in time spent in employment and profound changes in working life, there is limited coordinated research on occupation and health.We recently estimated that in Europe alone there is information available on more than 30 million individuals that could be used to study the association between working life and health. However, lack of standardization, inability to code large numbers of job-entries and inabilities to share data have hindered progress. In order to unlock the vault of occupational-health information novel ways of data acquisition, standardization, pooling and analyses have to be developed and implemented. The ability of pooling studies would greatly improve occupational health studies by increasing sample size for robust inference, and would allow risk stratification, identification of new risks, exploration of interactions with work and non-work-related factors and detailed analyses on the shapes of the exposure-response curves.In recent years we have seen progress in several different methodological aspects. Currently, new tools are available to collect information on work and work exposures. These include amongst others the use of sensors and mobile phone applications. Standardization of occupational information is essential for comparison of results between studies and for pooling of studies. This could be achieved by using common occupational coding schemes, use of automatic coding instruments and common exposure assessment tools. Virtual pooling of data has become possible by using data-shields which instead of bringing the data to the analyses bring the analyses to the data allowing federated analyses.As part of the OMEGA-NET symposium we will discuss the need for new tools and avenues of how to bring occupational health information together. We will present our inventory of novel tools to aid this process, and will discuss future needs.
O3D.7 Constances: a population-based cohort for occupational epidemiology
Authors: Goldberg Marcel , Descatha Alexis , Leclerc Annette , Roquelaure Yves , Siemiatycki Jack , Zins Marie 
Published: May 2020

The CONSTANCES general-purpose population-based cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community. CONSTANCES also provides useful public health information to the public health authorities. CONSTANCES was designed as a randomly selected sample of French adults aged 18–69 years at inception; 2 00 000 subjects will be included over a six-year period. At inclusion, the selected subjects are invited to complete questionnaires, including a lifetime job history, and to attend a Health Screening Centre (HSC) for a comprehensive health examination. A biobank is being set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and health data are collected from the French national administrative databases. Data collected for participants include social and demographic characteristics, socioeconomic status, life events, and behaviours. Regarding occupational factors, a full job history and a wealth of data on employment and organizational, chemical, biological, biomechanical and psychosocial lifelong exposure are collected at inception and during the follow-up. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To consider non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants was set up and will be followed through the same national databases as participants.Inclusion began in 2012 and more than 1 80 000 participants were enrolled by July 2018. Several projects on occupational risks are already in progress, and an Occupational Health Users Club was established. This platform and its potential contributions will be described, as well as the means for international investigators to access it.
O3D.9 Psychosocial context, somatic complaints, work ability, and job satisfaction in anaesthesia health professionals. setting up a prospective cohort study
Authors: Mijakoski Dragan , Minov Jordan , Karadzinska-Bislimovska Jovanka , Stoleski Sasho , Atanasovska Aneta , Bislimovska Dragana 
Published: May 2020

BackgroundPsychosocial context, characterized by the levels of job demands, shift/night work, burnout, and teamwork, as well as presence of certain somatic complaints (chronic respiratory, skin, and musculoskeletal symptoms) and health disorders could affect the work ability and job satisfaction of health professionals (HPs).The aim of this prospective cohort study will be to assess changes in self-reported psychosocial factors, work ability, and job satisfaction, as well as to evaluate the incidence of somatic complaints and health disorders in anaesthesia HPs. Additional objective of the study will be to evaluate associations between analysed variables.Cohort participantsHPs working in a health institution for anaesthesia, reanimation and intensive care from Skopje will be included in the first phase of the study with a possibility to enrol other health institutions during the next phases of the research. The first phase will involve about 120 anaesthesia HPs (about 50 physicians and 70 nurses).Data collection phasesAt enrolment point, the participants will be invited to complete questionnaires and to attend a preventive medical examination by a specialist in occupational medicine (OM). The follow-up will include an annually self-administered questionnaire as well as periodic visits to an OM specialist.Main types of data collectedData collected for participants will include demographic and job characteristics; physical, organisational, emotional, and cognitive job demands; characteristics of shift/night work; burnout dimensions; teamwork; presence of chronic respiratory, skin, and musculoskeletal symptoms; work ability index; and job satisfaction factors (planning issues, general attitudes, performance issues, management issues, supervisory issues, training and salary issues, and benefits issues). Regarding medical examination by an OM specialist, a plenty of data on health status as well as work ability, will be collected at enrolment phase, and during follow-up.
O3E.3 Changes in job security and mental health: an analysis of 14 annual waves of an australian working population panel survey
Authors: LaMontagne Anthony , Too Lan Say , Punnett Laura , Milner Allison 
Published: May 2020

BackgroundThere is increasing recognition of job insecurity as an emerging issue in public health. We sought to examine whether job security improvements were associated with improvements in mental health in a large, working population-representative repeated-measures panel study.MethodsWe used both within-person fixed effects (FE) and random effects (RE) regression to analyse data from 14 annual waves of a national Australian survey (19 169 persons, 1 06 942 observations). Mental Health Inventory-5 scores (outcome) were modeled in relation to self-reported job security (categorical, quintiles), adjusting for age, year, education, and job change in the past year.ResultsBoth FE and RE models showed stepwise improvements in MHI-5 scores with improving job security, with stronger exposure-outcome relationships in the RE models, and for men compared to women. All models showed roughly monotonic improvements in MHI-5 score by quintile of improvement in job security. The strongest relationship was observed in the RE model for males: for a one-quintile improvement in job security, beta=2.06 [1.67, 2.46], and the following for two- (3.94 [3.54, 4.34]), three- (5.82 [5.40, 6.24]), and four- (7.18 [6.71, 7.64]) quintile improvements. The FE model for males produced slightly smaller coefficients, reaching a maximum of 5.55 [5.06, 6.05] for a four-quintile improvement.ConclusionsThis Australian national panel study showed a strong dose-response relationship between job security and depression and anxiety symptoms. Stronger causal inference over previous observational research is supported by the dose-response finding and the relative consistency of the FE and RE results. Policy and practice intervention to improve job security could benefit population health.
O4A.1 Night shiftwork, dna methylation, and telomere length in female nurses
Authors: Carugno Michele , Crespi Eleonora , Bollati Valentina , Tarantini Letizia , Dioni Laura , Ferrari Luca , Bonzini Matteo , Consonni Dario , Maggioni Cristina , Costa Giovanni , Pesatori Angela Cecilia 
Published: May 2020

IntroductionStudies on female nurses have reported a higher breast cancer risk among night shift (NS) workers, without a clear understanding of the underlying biological mechanisms.AimTo assess the association between night shiftwork and molecular alterations potentially related to a higher carcinogenic risk, in details: DNA methylation of estrogen receptor (ER-Alpha, ER-Beta) and tumor suppressor (BRCA1, BRCA2, p53, p16) genes, global DNA methylation estimated on repeated elements (LINE-1, Alu), and telomere length (TL).Methods46 female nurses who had been working in NS for at least two years in a Hospital in Milan, Italy, were matched by age (30–45 years) and length of service (at least 5 years) with 51 female colleagues not working in NS. Each subject was administered a structured questionnaire and withdrawn a 12 ml blood sample. We applied linear regression models adjusted for age, BMI, smoking habit, parity, and oral contraceptive use.ResultsCurrently working in NS (yes/no) was associated with hypomethylation of ER-Alpha (β: −1.635, 95% CI: −2.715; −0.554). When examining both current and former NS workers, the number of years (NY) in NS was associated with hypermethylation of Alu (β: 0.078, 95% CI: 0.016; 0.138). After graphical inspection of the association between NYNS and TL, we classified the study population according to NS duration (<15 vs.≥15 years). Among workers with at least 15 years of NS, NYNS was associated with TL reduction (β: −0.065, 95% CI: −0.122; −0.008) and hypomethylation of ER-Alpha (β: −2.009, 95% CI: −3.164; −0.853). Association between NYNS and hypermethylation of p53, p16, BRCA1, BRCA2, and LINE-1 was much stronger, albeit not significant, in workers with at least 15 years of NS.ConclusionsOur findings show NS-associated epigenetic alterations that might be involved in processes such as cellular aging, genomic instability, and cancer development.
O1A.4 Assessment of pesticide-related pollution and occupational health of vegetable farmers
Authors: Lu Jinky Leilanie 
Published: May 2020

ObjectivesThis study assessed the pesticide exposure and the occupational health of the agricultural farmers in the Philippines. The study site is one of the largest vegetable-producing province in the Philippines.MethodsThis study used both survey questionnaire and physical health assessment, including mental state examination. The pesticide exposure was estimated based on the duration of years of use of pesticide, as well as the amount applied per spray application. The data results were segregated between gender because women are also heavily engaged in agriculture in this part of the Philippines.ResultsThe results showed that pesticide exposure usually happened during agricultural activities such as spray application in the field (63.9%), mixing (38.4%), loading (34.1%) and field re-entry (9.7%) The most frequently used pesticides were Tamaron (OP), Selecron (OP), and Dithane (Carbamate). The mean years of pesticide use was 14.23 years for males, and 15.4 years for fe-males. For the exposure to pesticides, expressed in terms of number of years and amount used per spray application, the average exposure of the males was 2,024.43 ml-years; and for females, it was 993.55. Among farmers, 49% complained of being sick because of work. Of those who got ill, a large percentage of this, 69.8%, did not receive any medi-cal attention. The most prevalent health symptoms were muscle pain (63.3%), easy fatigability (52.4%), and loss of appetite (27.5%). For the mini-mental state examination, abnormalities were found in 5.4% for males and 40.8% in females. The use of insecticide was associated with weak-ness, easy fatigability and weight loss.ConclusionPesticide exposure is considerable among the farmers. The occupational health condi-tions presented by the farmers can be linked with their pesticide investigation. Although this study has presented some risk factors associated with general health symptoms, further investigation should look into specific pesticide-health correlation.
O4A.6 Occupational exposure to extremely low frequency magnetic fields and melatonin in male rotating shift workers
Authors: Turner Michelle C , Gracia-Lavedan Esther , Castaño-Vinyals Gemma , Skene Debra J , Middleton Benita , Cardis Elisabeth , Kogevinas Manolis 
Published: May 2020

BackgroundOccupational exposure to extremely low frequency magnetic fields (ELF-MF) is a suspected cancer risk factor, however, the epidemiological literature is limited and potential biological mechanisms unclear. Night shift work and associated circadian misalignment, leading to decreased melatonin production is also suspected in cancer. It has been suggested that ELF-MF exposure may decrease melatonin production leading to the promotion of cancer development, however previous findings are inconsistent. We assessed ELF-MF exposure and melatonin production in a recent study of male rotating shift workers.MethodsA total of 50 male shift workers rotating in a 3 week night, 3 week evening, and 3 week morning schedule were recruited at a local car manufacturing facility. Personal full-shift measurements of ELF-MF exposure were performed (EMDEX II, 40–800 Hz) and urine samples from all voids over 24 hour collected on two working days (end of 3 week night and end of 3 week morning shifts). Urinary concentrations of 6-sulfatoxymelatonin (aMT6s), the main melatonin metabolite, were measured in all samples (creatinine corrected), with the mesor (24 hour mean) derived based on cosinor models.ResultsArithmetic mean (AM (SD)) and geometric mean (GM (GSD)) ELF-MF levels were 0.05 (0.06) µT and 0.03 (0.02) µT, respectively. Peak production of aMT6s occurred 9 hours later in night compared with morning shifts, though with a similar mesor indicating adaptation. The adjusted mesor varied somewhat by age group and other personal characteristics, and was somewhat lower among those with higher AM and GM ELF-MF levels (i.e. ≥50 th or 75th percentile), with differences ranging from 0.94–1.38 ng/mg creatinine/hour in the morning to 0.96–4.33 in the night shift observed, with some differences significant.ConclusionsOverall, small differences in mean aMT6s levels were observed according to ELF-MF. Workers during the night shift adapted, showing a delay in the peak time of aMT6s production compared to the day shift.
O4B.3 The impact of income support systems on healthcare quality and functional capacity in workers with LBP: a realist review
Authors: Donato Michael Di , Iles Ross , Lane Tyler , Collie Alex 
Published: May 2020

BackgroundLow back pain (LBP) is a leading cause of work disability. While absent from work, workers with LBP may receive income support from a system such as workers’ compensation or social security. Current evidence suggests that income support systems can influence recovery from LBP, but provides little evidence as to why and how these effects occur. This study examines how and in what contexts income support systems impact the healthcare quality and functional capacity of people with work disability and LBP.MethodsWe performed a realist review, a type of literature review that seeks to explain how social interventions and phenomena in certain contexts generate outcomes, rather than simply whether or not they do. Five initial theories about the mechanisms of the relationship were developed, tested, and refined by acquiring and synthesising academic literature from purposive and iterative electronic database searching. This process was supplemented by grey literature searching for policy documents and legislative summaries, and semi-structured interviews with experts in income support, healthcare, and LBP.ResultsIncome support systems influence healthcare quality through healthcare funding restrictions, healthcare provider administrative burden, and allowing an employer to select healthcare providers. Income support systems influence worker functional capacity through the level of participation and share of income support funding required of employers, and through certain administrative procedures. These mechanisms are often exclusively context-dependent, and generate differing and unintended outcomes depending on features of the healthcare and income support system, as well as other contextual factors such as socioeconomic status and labour force composition.ConclusionIncome support systems impact the healthcare quality and functional capacity of people with work disability and LBP through context-dependent financial control, regulatory, and administrative mechanisms. Future policy design and research efforts should consider how income support systems may indirectly influence workers with LBP via the workplace.
O4B.6 Do we need repeated measurements for reliable classification of case status regarding musculoskeletal pain?
Authors: Hillert Lena , Alderling Magnus , Lind Carl , Norberg Annika Lindahl , Forsman Mikael 
Published: May 2020

Musculoskeletal disorders (MSDs) are major causes for disability, reduced work ability and early exit from the labour market. The aetiology is understood to be multifactorial and MSDs are known to have a recurrent course characterized by development, recovery, reoccurrence and chronic states. Studies classifying participants as suffering from e.g. low back pain based on self-reported symptoms solely at one time are therefore at risk of just capturing the point prevalence of pain and not a more representative state characterizing the participants.In order to investigate how well a classification based on self-reported musculoskeletal complaints of the neck, shoulders and lower back in a baseline questionnaire represents the situation of the respondents´ pain and functional status over a 12 month period, we analysed data collected in a study on 129 employees at selected Swedish home-care providers. The participants completed a baseline questionnaire on work environment and mental and physical health and responded to questions on the impact on work capacity of pain sent monthly to their phones by text messages.The results show that classification into cases and non-cases cases based on reported musculoskeletal complaints at baseline was a statistically significant predictor of persistent differences between groups with regard to pain and work capacity throughout the 12 months covered by text messages. The variation in work capacity over time seemed to be more pronounced in case groups.In conclusion, classifying respondents as cases and non-cases based on self-reported musculoskeletal complaints of the neck, shoulders and lower back at baseline seems to be a good predictor of persistent differences in self-reported work capacity due to neck, shoulder and low back pain during the following year.