bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case‐Control Study
Authors: Mansour Anthony G. , Ahdab Rechdi , Daaboul Yazan , Korjian Serge , Morrison Daniel Alexander , Hariri Essa , Salem Maher , El Khoury Christelle , Riachi Naji , Aoun Bahous Sola 
Published: November 2019

ObjectiveWe aimed to examine arterial stiffness and vitamin K2 status in migraine subjects by comparison to controls.BackgroundMigraine is a primary headache disorder that has been associated with an increased risk of cardiovascular events. Mechanisms underlying this increased risk, however, remain unclear. Vitamin K2 deficiency emerged as a cardiovascular risk factor, but vitamin K2 status has never been explored in migraine subjects.Design and MethodsThis is a case‐control, single‐center, observational study that includes a cohort of subjects with migraine and their age‐ and sex‐matched controls. Arterial stiffness was measured using carotid‐femoral pulse wave velocity (cfPWV). Dephosphorylated‐uncarboxylated matrix‐Gla‐protein (dp‐ucMGP) was used as a marker for vitamin K2 status. A propensity‐matched scoring method was used.ResultsA total of 146 patients (73 matched pairs) were included in this study, of whom 89% were women with a mean age of 31.9 ± 8.4 years. Compared with controls, migraine patients had statistically significantly higher mean cfPWV (7.2 ± 1.1 vs 6.4 ± 0.8 m/s, 95% confidence interval (CI) of mean difference [0.45, 1.08], P < .001), as well as higher dp‐ucMGP (454.3 ± 116.7 pmol/L vs 379.8 ± 126.6 pmol/L, 95% CI of mean difference [34.63, 114.31], P < .001). Higher cfPWV was associated with higher dp‐ucMGP concentrations only in the migraine with aura (MWA) group. Moreover, migraine subjects had a higher frequency of vitamin K2 deficiency (dp‐ucMGP ≥ 500 pmol/L) compared to controls, but this association was not statistically significant (23/73 [31.5%] vs 16/73 [21.9%], P = .193).ConclusionsIndividuals with migraine have worse indices of arterial stiffness as compared with their age‐ and sex‐matched control subjects. This increase in arterial stiffness is associated with an increase in markers of vitamin K2 deficiency in the MWA group.
A practical method for reducing the interference due to lipaemia in coagulation tests
Authors: Gardiner Chris , Lane Philip , Tailor Hitesh , Mackie Ian J. 
Published: November 2019

AbstractIntroductionPlasma samples with gross lipaemia present a challenge for coagulation laboratories using optical analysers. High‐speed centrifugation may be used to remove excess lipids but it has not established whether this affects haemostasis tests. The aims were to determine whether the removal of lipid by centrifugation affects PT, APTT, fibrinogen, D‐dimer and von Willebrand factor activity measurements.MethodsTwenty‐six lipaemic samples (median [range]): triglyceride 4.6 mmol/L [0.5‐17.0]; cholesterol: 4.06 mmol/L [2.20‐9.41] and 20 plasmas spiked with Intralipid 20 or lipid isolated from patient plasmas (median triglyceride of 11.95 mmol/L [5.0‐17.0] and cholesterol 4.33 [3.22‐7.06]), were tested before and after the removal of the lipid layer by centrifugation (10000 g for 10 minutes). Tests were performed using the CS‐5100 (Sysmex) coagulation analyser.ResultsThirteen, 9, 3 and 1 of the lipaemic or spiked samples failed to give PT, APTT, fibrinogen and D‐dimer results, respectively. Centrifugation significantly reduced triglyceride (median 2.7, [0‐6.1 mmol/L]) and cholesterol (median 0.52 [0‐3.5]), allowing clot detection in all tests. There were no statistically significant differences in fibrinogen, D‐dimer or VWF levels in samples before and after lipid removal. A small but clinically insignificant change in PT and APTT was observed after lipid removal.ConclusionHigh‐speed centrifugation reduces lipaemia sufficiently to allow testing on an optical coagulation analyser without introducing clinically significant differences PT, APTT, fibrinogen, D‐dimer or VWF activity values.
Second‐order‐transition like characteristic contributes to strain temperature stability in (K, Na)NbO3‐based materials
Authors: Liu Gang , Yin Jie , Zhao Chunlin , Lv Xiang , Wu Jiagang 
Published: November 2019

AbstractHigh strain and good temperature stability are contradictory properties in (K, Na)NbO3 (KNN)‐based materials. Herein, good temperature stability with high strain is obtained in a multiphase coexistent [ie, orthorhombic‐tetragonal (O‐T) and rhombohedral‐orthorhombic‐tetragonal (R‐O‐T)] KNN. A second‐order transition‐like characteristic should contribute to the temperature stability, in which an intrinsic lattice structure forms a bridge between them. The observed second‐order transition‐like characteristic is due to the reduced discrepancy among different lattice symmetries and a broadened temperature region for the phase transition. These integrated factors can slow the latent heat in a first‐order transition and extend it over a wide temperature region, thereby exhibiting second‐order transition‐like behavior. Correspondingly, the abrupt increase in strain near the phase transition temperature significantly slows. In addition, the appearance of pure tetragonal symmetry (P4mm) is deferred to a much higher temperature than TO‐T, in which the strain will inevitably decrease. As a result, good temperature stability with a high strain response can be realized in multiphase coexistent KNN materials, including d33*=448 pm/V, ‐27.5%≤fluctuation≤4.2% for O‐T, and d33*=446 pm/V, ‐17.5%≤fluctuation≤7.6% for R‐O‐T, over the whole temperature range 25 °C‐190 °C.
Making Design Education (Even More) Complex: Exploring Complexity for an Amplified Mindset of Design
Authors: Moreira Mafalda 
Published: November 2019

AbstractAn Amplified Mindset of Design (AMD) has emerged from recent research on emerging design practices, as designers are once again re‐inventing their identity to include an adaptability to uncertainty and paradox. However, this is not yet visible in what design education offers. As designers intervene in complex contexts and embrace participatory, collaborative and interdisciplinary practices informed by strong ethical and sustainability concerns, design education must adjust and expand its scope to include, for example, collaboration, cross‐cultural and interdisciplinary skills, and a way of being in the world through design. In this article, I argue for the formal introduction and exploration of social complexity in design education to assist the development of an AMD in design students. Boundaries, dependence on context, edge of chaos, emergence and organisation were identified as key qualities of complex systems to introduce to students. Embodiment and visualisation techniques were used as the most appropriate vehicles for such an endeavour. In this article, I discuss the results of a qualitative research informed by action research in which I explore ways of teaching complexity to design students. The inquiry was driven by the following core research question: How can complexity can be taught in design education using visual and embodiment methods to encourage the development of an Amplified Mindset of Design?
Bridge or Barrier? Writing in Secondary Art & Design Education in the UK
Authors: Blunden Jennifer 
Published: November 2019

AbstractWhat role does writing play in secondary art & design education? In the context of current debates on access and participation in the visual arts, the nature of art discourse and the value of creative subjects within the curriculum, what impact do the existing requirements have on students, teachers and the broader arena of the visual arts? This article presents the findings‐to‐date of an ongoing pilot study which set out to explore these questions. Drawing on interviews with teachers and exam board representatives, and a review of student texts and exam board documents and resources, the study found that even though writing is only a minor part of what is an essentially practice‐based subject, it was a source of significant concern and confusion. A marked disconnect was revealed between intent and practice, which in turn highlighted a series of underlying values and beliefs that seemed to further drive this disconnect. The study calls for a wider discussion of the way writing is framed, used, supported and assessed in the art & design classroom, and the need to ensure that any pedagogy and resources developed align with the values as well as curriculum of art & design. It also previews how strategies created in the context of developing more inclusive and flexible writing skills among curators and other art museum professionals may offer a useful model. The study is part of a larger investigation into the discourse/s of the visual arts, with a focus on issues of access and participation.
Art and Design Education in the Ecology of Care
Authors: Tan Michael Koon Boon 
Published: November 2019

AbstractIn the light of challenges arising from contemporary issues such as inclusivity, sustainability and justice, the connections between art, design and caring appears to be pertinent. What role can artists and designers play in the ecology of care? How can we lead art and design students to connect and lend their creative skills to care needs? Drawing on the ethics of care and a relational view on health this article highlights the various teaching approaches and initiatives introduced at Nanyang Technological University, Singapore, to support and guide students to realise various art and design for health and wellbeing projects that provide opportunities for students to part take in ecology of care using their creative skills. Although creative explorations at the intersection of art, design and caring is still at an early stage, outcomes from this ongoing effort have been encouraging in response to the shifting social needs to create a more inclusive and flourishing society in Singapore.
Design Domain: Created Space, Creative Space
Authors: Stevens Thea 
Published: November 2019

AbstractIn this article, I describe and explore Design Domain, a large‐cohort course for which I am academic coordinator and which is enacted across six design programmes at the Glasgow School of Art (GSA). I unpack Design Domain’s context and intentionality as a ‘created space’, where student learners are exposed to different ways of thinking, making and doing, with an emphasis on working within discipline but pushing boundaries beyond the discipline. Next, I evaluate Design Domain as a ‘creative space’, unpacking its lineaments and evaluating its positives and challenges. Then, I set out initial reflections on the taxonomy of disciplinarities, arguing that these can be usefully reappraised when applied to a pedagogical framework like Design Domain, which blends predominantly individual learning with particular and specific points of collective commonality of purpose and action. Finally, I describe how I will go onto develop my understanding via an action research informed evaluation of a recent Design Domain project in Communication Design, where students of graphic design, photography and illustration worked together. I frame the type of critical questions I might ask of staff and student respondents in an action research informed evaluation study, and I offer a preliminary conclusion: that it is more appropriate to focus on ways of thinking than prescribing ways of doing, and that this might bring practice and process into a more adaptive theoretical framework.
Comparison of 24‐hour urine and 24‐hour diet recall for estimating dietary sodium intake in populations: A systematic review and meta‐analysis
Authors: McLean Rachael , Cameron Claire , Butcher Elizabeth , Cook Nancy R. , Woodward Mark , Campbell Norm R. C. 
Published: November 2019

AbstractThis systematic literature review and meta‐analysis examined whether 24‐hour diet recall is a valid way to measure mean population sodium intake compared with the gold standard 24‐hour urinary assessment. The authors searched electronic databases MEDLINE, Embase, and Scopus using pre‐defined terms. Studies were eligible for inclusion if they assessed adult humans in free‐living settings, and if they included group means for 24‐hour diet recall and 24‐hour urinary collection of sodium intake in the same participants. Studies that included populations with an active disease state that might interfere with normal sodium metabolism were excluded. Results of 28 studies are included in the meta‐analysis. Overall, 24‐hour diet recall underestimated population mean sodium intake by an average of 607 mg per day compared to the 24‐hour urine collection. The difference between measures from 24‐hour urine and 24‐hour diet recall was smaller in studies conducted in high‐income countries, in studies where multiple‐pass methods of 24‐hour diet recall were reported and where urine was validated for completeness. Higher quality studies also reported smaller differences between measures than lower quality studies. Monitoring of population sodium intake with 24‐hour urinary excretion remains the most accurate method of assessment. Twenty‐four‐hour diet recall tends to underestimate intake, although high‐quality 24‐hour diet recall improves accuracy, and may be used if 24‐hour urine is not feasible.
Early morning home blood pressure control among treated patients with controlled office blood pressure
Authors: Zuo Hui‐Juan , Song Xian‐Tao , Yang Hong‐Xia , Deng Li‐Qun , Wang Jin‐Wen 
Published: November 2019

AbstractElevated morning blood pressure (BP) has a significantly increased risk of cardiovascular events, so morning BP is of substantial clinical importance for the management of hypertension. This study aimed to evaluate early morning BP control and its determines among treated patients with controlled office BP. From May to October 2018, 600 treated patients with office BP < 140/90 mm Hg were recruited from hypertension clinics. Morning BP was measured at home for 7 days. Morning home systolic blood pressure (SBP) increased by an average of 11.5 mm Hg and that morning home diastolic blood pressure (DBP) increased by an average of 5.6 mm Hg compared with office BP. Morning home SBP, DBP, and their moving average were more likely to be lower among patients with a office SBP < 120 mm Hg than among patients with a office SBP ranging from 120 to 129 mm Hg and from 130 to 139 mm Hg (P < .001). A total of 45% of patients had early morning BP < 135/85 mm Hg. The following factors were significantly correlated with morning BP control: male sex, age of <65 years, absence of habitual snoring, no drinking, adequate physical activity, no habit of high salt intake, office BP < 120/80 mm Hg, and combination of a calcium channel blocker (CCB) and angiotensin receptor blocker or angiotensin‐converting enzyme inhibitor (ARB/ACEI). Less than half of patients with controlled office BP had controlled morning BP and that positive changes may be related to an office BP < 120/80 mm Hg, combination of a CCB and ACEI/ARB and a series of lifestyle adjustments.
Parent–child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability
Authors: Quiñones‐Camacho Laura E. , Fishburn Frank A. , Camacho M. Catalina , Hlutkowsky Christina O. , Huppert Theodore J. , Wakschlag Lauren S. , Perlman Susan B. 
Published: November 2019

BackgroundResearch to date has largely conceptualized irritability in terms of intraindividual differences. However, the role of interpersonal dyadic processes has received little consideration. Nevertheless, difficulties in how parent–child dyads synchronize during interactions may be an important correlate of irritably in early childhood. Innovations in developmentally sensitive neuroimaging methods now enable the use of measures of neural synchrony to quantify synchronous responses in parent–child dyads and can help clarify the neural underpinnings of these difficulties. We introduce the Disruptive Behavior Diagnostic Observation Schedule: Biological Synchrony (DB‐DOS:BioSync) as a paradigm for exploring parent–child neural synchrony as a potential biological mechanism for interpersonal difficulties in preschool psychopathology.MethodsUsing functional near‐infrared spectroscopy (fNIRS) 4‐ to 5‐year‐olds (N = 116) and their mothers completed the DB‐DOS:BioSync while assessing neural synchrony during mild frustration and recovery. Child irritability was measured using a latent irritability factor that was calculated from four developmentally sensitive indicators.ResultsBoth the mild frustration and the recovery contexts resulted in neural synchrony. However, less neural synchrony during the recovery context only was associated with more child irritability.ConclusionsOur results suggest that recovering after a frustrating period might be particularly challenging for children high in irritability and offer support for the use of the DB‐DOS:BioSync task to elucidate interpersonal neural mechanisms of developmental psychopathology.
Periostin as a novel biomarker of cardiovascular disease: A systematic evidence landscape of preclinical and clinical studies
Authors: Azharuddin Md , Adil Mohammad , Ghosh Pinaki , Kapur Prem , Sharma Manju 
Published: November 2019

AbstractBackgroundPeriostin is a matricellular protein, expressed in various normal adult and fetal tissues. Recently, elevated periostin levels have been reported in heart failure, coronary artery disease, and stroke. However, there is lack of clinical studies to clarify the prognostic significance of systemic periostin levels in cardiovascular diseases (CVDs). The aim of the study was to perform a systematic review of published evidence on periostin and CVDs, and to clarify the diagnostic and prognostic significance of systemic periostin levels in CVDs.MethodsA systematic search on PubMed was performed to identify relevant articles from inception to December 2018. The eligible studies evaluating the periostin expression and periostin levels in animal and human studies.ResultsA total of 24 relevant studies, including both animal and human data, were included. Periostin is significantly observed in myocardium tissue of failing hearts compared with control, and is also expressed in atherosclerotic plaques. Systemic periostin levels were significantly correlated with cardiac function and severity of CVD in several studies. A clinical study also observed positive correlation between periostin and N‐terminal pro b‐type natriuretic peptide (NT‐proBNP), highly sensitive troponin (hsTnT), and ST2 cardiac biomarker. Studies reported limited adjustment for potential confounders.ConclusionsThe evidence of current review support potential role of periostin in the pathophysiology of CVD. However, scarcity of data regarding the clinical use of periostin levels in the current management of CVDs further creates room for the future investigation. Therefore, further studies warrant to clarify its potential role, if any, as a novel cardiac biomarker.
Mapping the spatial variability of the field distribution of sterile Anastrepha ludens over a release area
Authors: Vanoye‐Eligio Venancio , Vázquez‐Sauceda María de la Luz , Rocandio‐Rodríguez Mario , Chacón‐Hernández Julio César , de la Rosa‐Manzano Edilia 
Published: November 2019

AbstractThe sterile insect technique (SIT) is an environmental‐friendly method used against Anastrepha ludens Loew (Diptera: Tephritidae) populations. This study aimed to perform an analysis of the spatial variability of the field distribution of sterile A. ludens using a geostatistical approach along with Geographic Information Systems (GIS). Field data on captures of sterile A. ludens during a Valencia orange season over a release area were analysed using spherical, exponential and Gaussian variograms. Such variograms were evaluated by criteria such as the mean absolute error, average standard error, root mean square error and the coefficient of determination. Results revealed a spatially structured distribution of sterile A. ludens across the release area. Interpolated models by Ordinary Kriging technique exhibited continuous surfaces evidencing spatial heterogeneity of the distribution of flies. Such a result evidenced that the spatial dynamics of flies significantly varied despite the planned uniform coverage of the release. The GIS led to integrating spatial information of the spatial dynamics through one single model. The release activity should be improved westward of the studied area, as the final model suggested that the ratio sterile: wild is lower than that in the east. This study provides insights into the spatial analysis of the distribution of sterile flies further than one single geographical point. Moreover, it highlights geostatistical techniques and GIS as useful tools for the assessment of the impact and quality of the release activity over fruit‐growing areas subjected to an area‐wide integrated pest management approach.
Risk for Health Events After Deprescribing Acetylcholinesterase Inhibitors in Nursing Home Residents With Severe Dementia
Authors: Niznik Joshua D. , Zhao Xinhua , He Meiqi , Aspinall Sherrie L. , Hanlon Joseph T. , Hanson Laura C. , Nace David , Thorpe Joshua M. , Thorpe Carolyn T. 
Published: November 2019

BACKGROUND/OBJECTIVEReevaluation of the appropriateness of acetylcholinesterase inhibitors (AChEIs) is recommended in older adults with severe dementia, given the lack of strong evidence to support their continued effectiveness and risk for medication‐induced adverse events. We sought to evaluate the impact of deprescribing AChEIs on risk of all‐cause events (hospitalizations, emergency department visits, and mortality) and serious falls or fractures in older nursing home (NH) residents with severe dementia.DESIGNAnalysis of 2015 to 2016 data from Medicare claims, Part D prescriptions, Minimum DataSet (MDS) version 3.0, Area Health Resource File, and Nursing Home Compare. Marginal structural models with inverse probability of treatment weights were used to evaluate the association of deprescribing AChEIs and all‐cause negative events as well as serious falls or fractures.SETTINGUS Medicare‐certified NHs.PARTICIPANTSNonskilled NH residents, aged 65 years and older, with severe dementia receiving AChEIs within the first 14 days of an MDS assessment in 2016 (n = 37 106).RESULTSThe sample was primarily white (78.7%), female (75.5%), and aged 80 years or older (77.4%). Deprescribing AChEIs was associated with an increased likelihood of all‐cause negative events in unadjusted models (odds ratio [OR] = 1.17; 95% confidence interval [CI] = 1.11‐1.23; P < .01), but not in fully adjusted models (adjusted OR [aOR] = 1.00; 95% CI = 0.94‐1.06; P = .94). By contrast, deprescribing was associated with a reduced likelihood of serious falls or fractures in unadjusted models (OR = 0.59; 95% CI = 0.52‐0.66; P < .001) and remained significant in adjusted models (aOR = 0.64; 95% CI = 0.56‐0.73; P < .001).CONCLUSIONDeprescribing AChEIs was not associated with a significant increase in the likelihood for all‐cause negative events and was associated with a reduced likelihood of falls and fractures in older NH residents with dementia. Our findings suggest that deprescribing AChEIs is a reasonable approach to reduce the risk of serious falls or fractures without increasing the risk for all‐cause events. J Am Geriatr Soc 68:699–707, 2020