bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting meaningful recovery with digital mental health care
Authors: Carpenter-Song Elizabeth 
Published: February 2020

AbstractThere is growing interest in digital mental health as well as accumulating evidence of the potential for technology-based tools to augment traditional mental health services and to potentially overcome barriers to access and use of mental health services. Our research group has examined how people with mental illnesses think about and make use of technology in their everyday lives as a means to provide insight into the emerging paradigm of digital mental health. This research has been guided by anthropological approaches that emphasise lived experience and underscore the complexity of psychiatric recovery. In this commentary I describe how an anthropological approach has motivated us to ask how digital technology can be leveraged to promote meaningful recovery for people with mental illnesses and to develop a new approach to the integration of technology-based tools for people with mental illnesses.
Estimation of Depth to Bottom of Magnetic Sources Using Spectral Methods: Application on Iran's Aeromagnetic Data
Authors: Kumar Raj , Bansal A. R. , Ghods Abdolreza 
Published: February 2020

AbstractThe effect of window size while estimating the depth to bottom of magnetic sources (DBMS) is examined on the synthetic 2‐D magnetic field data. The data are generated for 3‐D fractal magnetization models assuming different combinations of depth to the top and bottom of magnetic sources. The depths are estimated assuming an uncorrelated and correlated random distribution of sources. The depths to the top estimated for fractal distribution of sources are found within 70% of the true values for all window sizes, whereas the values for the uncorrelated random distributions are far from the real depths. The DBMS for the correlated random distribution of sources are estimated within 70–80% of the true values for the window sizes of 5 times or more of the targeted depths. The modified centroid method is found to provide better estimations as compared to scaling‐spectral peak modeling. The modified centroid method is applied to the aeromagnetic data of Iran to estimate the DBMS using a window size of 200 × 200 km2. The shallow DBMS between 12 and 20 km are obtained for the Quaternary Sabalan and Sahand volcanoes to the NW of Iran, the central and NE of central Iran, the central Zagros, NW of Tabas block, and the south of the Lut Block. The deepest DBMS of the order of 40 km is found in the Makran. The rest of Iranian Plateau is characterized by DBMS of 20 to 30 km. The shallow DBMS are found in correlation with the depth of the Ophiolites.
Parental and social factors in relation to child psychopathology, behavior, and cognitive function
Authors: Zhang Han , Lee Zu Xuan , White Tonya , Qiu Anqi 
Published: February 2020

AbstractParental and social factors have long-term impact on the neurodevelopment of offspring, but tend to highly covary with each other. Thus, it is difficult to parse out which parental and social factor contributes most to neurodevelopmental outcomes. This study aimed to assess clusters of parental and social factors associated with child psychopathology, behavioral problems, and cognition. This study employed the data of 11,875 children (9 to 11 years) from the Adolescent Brain Cognitive Development (ABCD) study. Principal component analysis (PCA) was performed on 39 environmental measures and 30 child behavior and cognitive measures separately to identify clusters of parental and social factors and clusters of child psychopathology, behaviour, and cognition. Regression analysis was used to examine independent effects of each cluster of parental and social factors on child psychopathology, behavioral problems, and cognition. Greater Parent Psychopathology cluster was associated with greater Child Psychopathology cluster. Moreover, greater Socioeconomic Status cluster was associated with greater child General Cognition and Executive Function but less Behavioral Inhibition clusters. Greater Proximal Social Environment and Interaction cluster were associated with less child Impulsive Behavior and Behavioral Inhibition, but greater Behavioral Activation cluster. The environmental clusters related to birth outcomes, maternal tobacco, and drug use were not significantly related to child psychopathology, behavior, and cognition. Our findings suggest that socioeconomic status, parental psychopathology, and social environment and interactions are the strongest risks for behavioral problems and cognitive performance in a general child population. Intervention programs should target modifiable factors within these domains.
Understanding solvent effects on adsorption and protonation in porous catalysts
Authors: Gould Nicholas S. , Li Sha , Cho Hong Je , Landfield Harrison , Caratzoulas Stavros , Vlachos Dionisios , Bai Peng , Xu Bingjun 
Published: February 2020

AbstractSolvent selection is a pressing challenge in developing efficient and selective liquid phase catalytic processes, as predictive understanding of the solvent effect remains lacking. In this work, an attenuated total reflection infrared spectroscopy technique is developed to quantitatively measure adsorption isotherms on porous materials in solvent and decouple the thermodynamic contributions of van der Waals interactions within zeolite pore walls from those of pore-phase proton transfer. While both the pore diameter and the solvent identity dramatically impact the confinement (adsorption) step, the solvent identity plays a dominant role in proton-transfer. Combined computational and experimental investigations show increasingly favorable pore-phase proton transfer to pyridine in the order: water < acetonitrile < 1,4 – dioxane. Equilibrium methods unaffected by mass transfer limitations are outlined for quantitatively estimating fundamental thermodynamic values using statistical thermodynamics.
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
Authors: Minato Takafumi , Nirasawa Satoru , Sato Teruki , Yamaguchi Tomokazu , Hoshizaki Midori , Inagaki Tadakatsu , Nakahara Kazuhiko , Yoshihashi Tadashi , Ozawa Ryo , Yokota Saki , Natsui Miyuki , Koyota Souichi , Yoshiya Taku , Yoshizawa-Kumagaye Kumiko , Motoyama Satoru , Gotoh Takeshi , Nakaoka Yoshikazu , Penninger Josef M. , Watanabe Hiroyuki , Imai Yumiko , Takahashi Saori , Kuba Keiji 
Published: February 2020

AbstractAngiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a carboxypeptidase derived from Paenibacillus sp. B38, is an ACE2-like enzyme to decrease angiotensin II levels in mice. In protein 3D structure analysis, B38-CAP homolog shares structural similarity to mammalian ACE2 with low sequence identity. In vitro, recombinant B38-CAP protein catalyzed the conversion of angiotensin II to angiotensin 1–7, as well as other known ACE2 target peptides. Treatment with B38-CAP suppressed angiotensin II-induced hypertension, cardiac hypertrophy, and fibrosis in mice. Moreover, B38-CAP inhibited pressure overload-induced pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction in mice. Our data identify the bacterial B38-CAP as an ACE2-like carboxypeptidase, indicating that evolution has shaped a bacterial carboxypeptidase to a human ACE2-like enzyme. Bacterial engineering could be utilized to design improved protein drugs for hypertension and heart failure.
Dinucleoside polyphosphates act as 5′-RNA caps in bacteria
Authors: Hudeček Oldřich , Benoni Roberto , Reyes-Gutierrez Paul E. , Culka Martin , Šanderová Hana , Hubálek Martin , Rulíšek Lubomír , Cvačka Josef , Krásný Libor , Cahová Hana 
Published: February 2020

AbstractIt has been more than 50 years since the discovery of dinucleoside polyphosphates (NpnNs) and yet their roles and mechanisms of action remain unclear. Here, we show that both methylated and non-methylated NpnNs serve as RNA caps in Escherichia coli. NpnNs are excellent substrates for T7 and E. coli RNA polymerases (RNAPs) and efficiently initiate transcription. We demonstrate, that the E. coli enzymes RNA 5′-pyrophosphohydrolase (RppH) and bis(5′-nucleosyl)-tetraphosphatase (ApaH) are able to remove the NpnN-caps from RNA. ApaH is able to cleave all NpnN-caps, while RppH is unable to cleave the methylated forms suggesting that the methylation adds an additional layer to RNA stability regulation. Our work introduces a different perspective on the chemical structure of RNA in prokaryotes and on the role of RNA caps. We bring evidence that small molecules, such as NpnNs are incorporated into RNA and may thus influence the cellular metabolism and RNA turnover.
Role of cell-type specific nucleosome positioning in inducible activation of mammalian promoters
Authors: Oruba Agata , Saccani Simona , van Essen Dominic 
Published: February 2020

AbstractThe organization of nucleosomes across functional genomic elements represents a critical layer of control. Here, we present a strategy for high-resolution nucleosome profiling at selected genomic features, and use this to analyse dynamic nucleosome positioning at inducible and cell-type-specific mammalian promoters. We find that nucleosome patterning at inducible promoters frequently resembles that at active promoters, even before stimulus-driven activation. Accordingly, the nucleosome profile at many inactive inducible promoters is sufficient to predict cell-type-specific responsiveness. Induction of gene expression is generally not associated with major changes to nucleosome patterning, and a subset of inducible promoters can be activated without stable nucleosome depletion from their transcription start sites. These promoters are generally dependent on remodelling enzymes for their inducible activation, and exhibit transient nucleosome depletion only at alleles undergoing transcription initiation. Together, these data reveal how the responsiveness of inducible promoters to activating stimuli is linked to cell-type-specific nucleosome patterning.
The Prosigna 50-gene profile and responsiveness to adjuvant anthracycline-based chemotherapy in high-risk breast cancer patients
Authors: Jensen Maj-Britt , Lænkholm Anne-Vibeke , Balslev Eva , Buckingham Wesley , Ferree Sean , Glavicic Vesna , Dupont Jensen Jeanette , Søegaard Knoop Ann , Mouridsen Henning T. , Nielsen Dorte , Nielsen Torsten O. , Ejlertsen Bent 
Published: February 2020

AbstractThe DBCG89D trial randomized high-risk early breast cancer patients to adjuvant CMF (cyclophosphamide, methotrexate and fluorouracil) or CEF (cyclophosphamide, epirubicin and fluorouracil). Prosigna assays were performed by researchers with no access to clinical data. Time to distant recurrence (DR) was the primary endpoint, time to recurrence (TR) and overall survival (OS) secondary. Among the 980 Danish patients enrolled, Prosigna results were obtained in 686. Continuous ROR score was associated with DR for CMF (adjusted hazard ratio (HR) 1.20, 95% CI 1.09–1.33), and for CEF (HR 1.04, 95% CI 0.92–1.18), Pinteraction = 0.06. DR was significantly longer in CEF compared to CMF treated patients with Her2-enriched tumors (HR 0.58, 95% CI 0.38–0.86), but not in patients with luminal tumors. Heterogeneity of treatment effect was significant for TR and OS. In this prospective-retrospective analysis, patients with Her2-enriched breast cancer derived substantial benefit from anthracycline chemotherapy whereas anthracyclines are not an essential component of chemotherapy for patients with luminal subtypes. The benefit of CEF vs. CMF correlated with increasing ROR Score.
Stimulated Brillouin scattering of backward stimulated Raman scattering
Authors: Feng Qingsong , Cao Lihua , Liu Zhanjun , Zheng Chunyang , He Xiantu 
Published: February 2020

AbstractThe rescattering of backward stimulated Raman scattering (BSRS) by stimulated Brillouin scattering (SBS) is found in the high electron density region by relativistic Vlasov-Maxwell simulation and particle-in-cell (PIC) simulation, where the BSRS is in the regime of absolute instability and dominates in all the scatterings. Both one dimension (1D) Vlasov simulation and two dimension (2D) PIC simulation have been given to verify that there exists SBS of BSRS in the regime of absolute instability for BSRS. The SBS of BSRS will be even stronger than forward stimulated Raman scattering (FSRS) and SBS in regime of absolute instability for BSRS. Thus, besides Langmuir decay instability and laser energy absorption, the SBS of BSRS is also an important saturation mechanism of BSRS in high electron density region.
RETRACTED ARTICLE: A Mathematical Model for Vibration Behavior Analysis of DNA and Using a Resonant Frequency of DNA for Genome Engineering
Authors: Marvi Mobin , Ghadiri Majid 
Published: February 2020

AbstractThe DNA molecule is the most evolved and most complex molecule created by nature. The primary role of DNA in medicine is long-term storage of genetic information. Genetic modifying is one of the most critical challenges that scientists face. On the other hand, it is said that under the influence of acoustic, electromagnetic, and scalar waves, the genetic code of DNA can be read or rewritten. In this article, the most accurate and comprehensive dynamic model will be presented for DNA. Each of the two strands is modeled with an out of plane curved beam and then by doubling this two strands with springs, consider the hydrogen bond strength between this two strands. Beams are traditionally descriptions of mechanical engineering structural elements or building. However, any structure such as automotive automobile frames, aircraft components, machine frames, and other mechanical or structural systems contain beam structures that are designed to carry lateral loads are analyzed similarly. Also, in this model, the mass of the nucleobases in the DNA structure, the effects of the fluid surrounding the DNA (nucleoplasm) and the effects of temperature changes are also considered. Finally, by deriving governing equations from Hamilton’s principle method and solving these equations with the generalized differential quadrature method (GDQM), the frequency and mode shape of the DNA is obtained for the first time. In the end, validation of the obtained results from solving the governing equations of mathematical model compared to the obtained results from the COMSOL software is confirmed. By the help of these results, a conceptual idea for controlling cancer with using the DNA resonance frequency is presented. This idea will be presented to stop the cancerous cell’s protein synthesis and modifying DNA sequence and genetic manipulation of the cell. On the other hand, by the presented DNA model and by obtaining DNA frequency, experimental studies of the effects of waves on DNA such as phantom effect or DNA teleportation can also be studied scientifically and precisely.
Diversity and function of multicopper oxidase genes in the stinkbug Plautia stali
Authors: Nishide Yudai , Kageyama Daisuke , Hatakeyama Masatsugu , Yokoi Kakeru , Jouraku Akiya , Tanaka Hiromitsu , Koga Ryuichi , Futahashi Ryo , Fukatsu Takema 
Published: February 2020

AbstractMulticopper oxidase (MCO) genes comprise multigene families in bacteria, fungi, plants and animals. Two families of MCO genes, MCO1 (laccase1) and MCO2 (laccase2), are conserved among diverse insects and relatively well-characterized, whereas additional MCO genes, whose biological functions have been poorly understood, are also found in some insects. Previous studies reported that MCO1 participates in gut immunity and MCO2 plays important roles in cuticle sclerotization and pigmentation of insects. In mosquitoes, MCO2 was reported to be involved in eggshell sclerotization and pigmentation, on the ground that knockdown of MCO2 caused deformity and fragility of the eggshell. Here we identified a total of 7 MCO genes, including PsMCO1 and PsMCO2, and investigated their expression and function in the brown-winged green stinkbug Plautia stali. RNA interference (RNAi) knockdown of MCO genes by injecting double-stranded RNA (dsRNA) into nymphs revealed that MCO2, but not the other 6 MCOs, is required for cuticle sclerotization and pigmentation, and also for survival of P. stali. Trans-generational knockdown of MCO2 by injecting dsRNA into adult females (maternal RNAi) resulted in the production of unhatched eggs despite the absence of deformity or fragility of the eggshell. These results suggested that MCO2 plays an important role in sclerotization and pigmentation of the cuticle but not in eggshell integrity in P. stali. Maternal RNAi of any of the other 6 MCO genes and 3 tyrosinase genes affected neither survival nor eggshell integrity of P. stali. Contrary to the observations in the red flour beetle and the brown rice planthopper, RNAi knockdown of MCO6 (MCORP; Multicopper oxidase related protein) exhibited no lethal effects on P. stali. Taken together, our findings provide insight into the functional diversity and commonality of MCOs across hemipteran and other insect groups.
Seeds of Life in Space (SOLIS)
Authors: Favre C. , Vastel C. , Jimenez-Serra I. , Quénard D. , Caselli P. , Ceccarelli C. , Chacón-Tanarro A. , Fontani F. , Holdship J. , Oya Y. , Punanova A. , Sakai N. , Spezzano S. , Yamamoto S. , Neri R. , López-Sepulcre A. , Alves F. , Bachiller R. , Balucani N. , Bianchi E. , Bizzocchi L. , Codella C. , Caux E. , De Simone M. , Enrique Romero J. , Dulieu F. , Feng S. , Jaber Al-Edhari A. , Lefloch B. , Ospina-Zamudio J. , Pineda J. , Podio L. , Rimola A. , Segura-Cox D. , Sims I. R. , Taquet V. , Testi L. , Theulé P. , Ugliengo P. , Vasyunin A. I. , Vazart F. , Viti S. , Witzel A. 
Published: February 2020

Aims. The Seeds Of Life In Space IRAM/NOEMA large program aims at studying a set of crucial complex organic molecules in a sample of sources with a well-known physical structure that covers the various phases of solar-type star formation. One representative object of the transition from the prestellar core to the protostar phases has been observed toward the very low luminosity object (VeLLO) L1521F. This type of source is important to study to link prestellar cores and Class 0 sources and also to constrain the chemical evolution during the process of star formation.
Methods. Two frequency windows (81.6–82.6 GHz and 96.65–97.65 GHz) were used to observe the emission from several complex organics toward the L1521F VeLLO. These setups cover transitions of ketene (H2CCO), propyne (CH3CCH), formamide (NH2CHO), methoxy (CH3O), methanol (CH3OH), dimethyl ether (CH3OCH3), and methyl formate (HCOOCH3).
Results. Only two transitions of methanol (A+, E2) have been detected in the narrow window centered at 96.7 GHz (with an upper limit on E1) in a very compact emission blob (~7′′ corresponding to ~1000 au) toward the northeast of the L1521F protostar. The CS 2–1 transition is also detected within the WideX bandwidth. Consistently with what has been found in prestellar cores, the methanol emission appears ~1000 au away from the dust peak. The location of the methanol blob coincides with one of the filaments that have previously been reported in the literature. The excitation temperature of the gas inferred from methanol is (10 ± 2) K, while the H2 gas density (estimated from the detected CS 2–1 emission and previous CS 5–4 ALMA observations) is a factor >25 higher than the density in the surrounding environment (n(H2) ≥ 107 cm−3).
Conclusions. Based on its compactness, low excitation temperature, and high gas density, we suggest that the methanol emission detected with NOEMA is (i) either a cold and dense shock-induced blob that formed recently (≤ a few hundred years) by infalling gas or (ii) a cold and dense fragment that may just have been formed as a result of the intense gas dynamics within the L1521F VeLLO system.
Medizinische Adaptive Kompressionssysteme sind Flachstrick-Kompressionsstrümpfen in der KPE Phase II nicht unterlegen
Authors: Reißhauer Anett , Kornappel Simone , Tsatrafilis Emmanouil , Stroux Andrea , Liebl Max Emanuel 
Published: February 2020

ZusammenfassungHintergrund Medizinische Adaptive Kompressionssysteme (MAK) sind mit Klettverschlüssen adjustierbare Kompressionsbandagen. Diese erweitern das Spektrum der therapeutischen Optionen in der komplexen physikalischen Entstauungstherapie (KPE). Die Studienlage zu MAK ist spärlich, es werden Vorteile in der der KPE Phase I beschrieben. Über die Durchführbarkeit und Sicherheit der Anwendung von MAK in der KPE Phase II existiert keine belastbare Evidenz.Methoden Prospektive, randomisierte Nichtunterlegenheitsstudie. Probanden mit symmetrischen lymphostatischen Ödemen der Unterschenkel (n=30) wurden parallel mit neu angepasster Flachstrick-Kompression (FS) und MAK 3 Tage lang behandelt. Primäres Outcome waren die perometrisch gemessenen Volumeneffekte der MAK im Vergleich mit der Referenztherapie (FS). Zudem wurden die Anwendungssicherheit und die Handhabung (Patientenperspektive) überprüft.Ergebnisse MAK sind, auch ohne regelmäßiges Nachjustieren, der Referenztherapie mit FS in der KPE Phase II nicht unterlegen (Vergleich der Differenzen der Volumeneffekte; p=0,163; 95%-KI [−38,2;+6,8] bei einem apriori definierten Äquivalenzbereich von±50 ml). MAK zeigten keine Nebenwirkungen. Patienten berichten im Vergleich mit FS ein signifikant leichteres An- und Ablegen der MAK bei vergleichbarem Tragekomfort.Schlussfolgerung Die Daten belegen die Nichtunterlegenheit von MAK gegen die Referenztherapie mit FS. MAK können in der Erhaltungstherapie von lymphostatischen Erkrankungen als alternative Kompressionstherapie eingesetzt werden. Die Anwendung (Selbstanlage) kann als sicher eingestuft werden. Eine gute Einweisung von Patienten ist bedeutsam. Patienten mit Schwierigkeiten in der Handhabung von Kompressionsstrümpfen beim An- und Ausziehen können von MAK profitieren. Patienten mit sehr ausgeprägten Ödemen müssen während der MAK-Nutzung gegebenenfalls größere Schuhe tragen. Studien mit längeren Beobachtungsdauern sollten folgen.