bluuebunny/crossref_metadata_2025_split huggingface dataset:
STATE DEPENDENCE IN LABOR MARKET FLUCTUATIONS
Authors: Pizzinelli Carlo , Theodoridis Konstantinos , Zanetti Francesco 
Published: March 2020

AbstractThis article documents state dependence in labor market fluctuations. Using a Threshold Vector Autoregression (TVAR) model, we establish that the unemployment rate, the job separation rate, and the job‐finding rate (JFR) exhibit a larger response to productivity shocks during periods with low aggregate productivity. A Diamond–Mortensen–Pissarides model with endogenous job separation and on‐the‐job search replicates these empirical regularities well. We calibrate the model to match the standard deviation of the job‐transition rates explained by productivity shocks in the TVAR, and show that the model explains 88% of the state dependence in the unemployment rate, 76% for the separation rate and 36% for the JFR. The key channel underpinning state dependence in both job separation and JFRs is the interaction of the firm's reservation productivity level and the distribution of match‐specific idiosyncratic productivity. Results are robust across several variations to the baseline model.
Nurse resilience: A concept analysis
Authors: Cooper Alannah L. , Brown Janie A. , Rees Clare S. , Leslie Gavin D. 
Published: March 2020

AbstractNurse resilience is attracting increasing attention in research and practice. Possession of a high level of resilience is cited as being crucial for nurses to succeed professionally and manage workplace stressors. There is no agreed definition of nurse resilience. A concept analysis was undertaken to examine nurse resilience using a priori selected analysis framework. This concept analysis aims to systematically analyse resilience as it relates to nurses and establish a working definition of nurse resilience. Sixty‐nine papers met the search criteria for inclusion. Key attributes of nurse resilience were social support, self‐efficacy, work–life balance/self‐care, humour, optimism, and being realistic. Resilience enables nurses to positively adapt to stressors and adversity. It is a complex and dynamic process which varies over time and context and embodies both individual attributes and external resources. Sustaining nurse resilience requires action and engagement from both individuals and organizations.
Social, commercial, or both? An exploratory study of the identity orientation of digital social innovations
Authors: Bonina Carla , López‐Berzosa David , Scarlata Mariarosa 
Published: March 2020

AbstractThe information systems literature has studied digital innovation extensively and focused primarily on its commercial related objectives. Yet, digital social innovations (DSIs) seek to solve social problems, while implementing commercially viable approaches. Drawing from the social entrepreneurship literature and using computational social science methods, we identify the peculiar utilitarian (commercial) and collectivistic (social) identity orientations that shape DSI. We use a sample of 292 DSI initiatives from Latin America and find that DSIs present both utilitarian and collectivist identity orientation. We also find that the collectivistic identity orientation tends to be more salient in less developed contexts. This allows us to discuss implications for the research on DSI and to open up a discussion on the role of context and possible tensions that may emerge in combining both identity orientations.
Issues of Power and Representation: Adapting Positionality and Reflexivity in Community‐Based Design
Authors: Schiffer Anne 
Published: March 2020

AbstractIncreasingly designers from an array of different disciplinary backgrounds work in international and community development, yet design education rarely prepares them for the challenges and roles in this context. The article reflects on issues of power and representation during design research in The Gambia by adapting reflexivity and positionality which are key concepts established in development studies. Reflections are based on research carried out in The Gambia since 2010 which is comprised of phases of immersion, mapping and co‐design. They provide in‐depth insights currently lacking in design literature that demonstrate the value of reflexivity and positionality to iterate roles and methods in community‐based design. Whilst not suggesting particular teaching methods, the article proposes the integration of these concepts into existing structures to better prepare students for increasingly common futures in the workplace. Broader themes that emerge and can be adapted to different design contexts include building trust, entanglement in power dynamics between different actors, personal vulnerability, as well as the need to challenge problems as starting points for design interventions.
Identification of critical isthmus using coherent mapping in patients with scar‐related atrial tachycardia
Authors: Vicera Jennifer Jeanne B. , Lin Yenn‐Jiang , Lee Po‐Tseng , Chang Shih‐Lin , Lo Li‐Wei , Hu Yu‐Feng , Chung Fa‐Po , Lin Chin‐Yu , Chang Ting‐Yung , Tuan Ta‐Chuan , Chao Tze‐Fan , Liao Jo‐Nan , Wu Cheng‐I , Liu Chih‐Min , Lin Chung‐Hsing , Chuang Chieh‐Mao , Chen Chun‐Chao , Chin Chye Gen , Liu Shin‐Huei , Cheng Wen‐Han , Tai Le Phat , Huang Sung‐Hao , Chou Ching‐Yao , Lugtu Isaiah , Liu Ching‐Han , Chen Shih‐Ann 
Published: March 2020

AbstractIntroductionAccurate identification of slow conducting regions in patients with scar‐related atrial tachycardia (AT) is difficult using conventional electrogram annotation for cardiac electroanatomic mapping (EAM). Estimating delays between neighboring mapping sites is a potential option for activation map computation. We describe our initial experience with CARTO 3 Coherent Mapping (Biosense Webster Inc,) in the ablation of complex ATs.MethodsTwenty patients (58 ± 10 y/o, 15 males) with complex ATs were included. We created three‐dimensional EAMs using CARTO 3 system with CONFIDENSE and a high‐resolution mapping catheter (Biosense Webster Inc). Local activation time and coherent maps were used to aid in the identification of conduction isthmus (CI) and focal origin sites. System‐defined slow or nonconducting zones and CI, defined by concealed entrainment (postpacing interval < 20 ms), CV < 0.3 m/s and local fractionated electrograms were evaluated.ResultsTwenty‐six complex ATs were mapped (mean: 1.3 ± 0.7 maps/pt; 4 focal, 22 isthmus‐dependent). Coherent mapping was better in identifying CI/breakout sites where ablation terminated the tachycardia (96.2% vs 69.2%; P = .010) and identified significantly more CI (mean/chamber 2.0 ± 1.1 vs 1.0 ± 0.7; P < .001) with narrower width (19.8 ± 10.5 vs 43.0 ± 23.9 mm; P < .001) than conventional mapping. Ablation at origin and CI sites was successful in 25 (96.2%) with long‐term recurrence in 25%.ConclusionsCoherent mapping with conduction velocity vectors derived from adjacent mapping sites significantly improved the identification of CI sites in scar‐related ATs with isthmus‐dependent re‐entry better than conventional mapping. It may be used in conjunction with conventional mapping strategies to facilitate recognition of slow conduction areas and critical sites that are important targets of ablation.
Islets of heterogeneous myocardium within the scar in cardiac magnetic resonance predict ventricular tachycardia after myocardial infarction
Authors: Malaczynska‐Rajpold Katarzyna , Blaszyk Krzysztof , Kociemba Anna , Pyda Malgorzata , Posadzy‐Malaczynska Anna , Grajek Stefan 
Published: March 2020

AbstractIntroductionWe assessed findings in cardiac magnetic resonance (CMR) as predictors of ventricular tachycardia (VT) after myocardial infarction (MI), which could allow for more precise identification of patients at risk of sudden cardiac death.MethodsForty‐eight patients after prior MI were enrolled and divided into two groups: with (n = 24) and without (n = 24) VT. VT was confirmed by electrophysiological study and exit site was estimated based on 12‐lead electrocardiogram. All patients underwent CMR with late gadolinium enhancement.ResultsThe examined groups did not differ significantly in clinical and demographical parameters (including LV ejection fraction). There was a significant difference in the infarct age between the VT and non‐VT group (15.8 ± 8.4 vs 7.1 ± 6.7 years, respectively; P = .002), with the cut‐off point at the level of 12 years. In the scar core, islets of heterogeneous myocardium were revealed. They were defined as areas of potentially viable myocardium within or adjacent to the core scar. The number of islets was the strongest independent predictor of VT (odds ratio [OR], 1.42; confidence interval [CI], 1.17‐1.73), but total islet size and the largest islet area were also significantly higher in the VT group (OR, 1.04; CI, 1.02‐1.07 and OR, 1.16; CI, 1.01‐1.27, respectively). Myocardial segments with fibrosis forming 25%‐75% of the ventricular wall were associated with a higher incidence of VT (7.5 ± 2.1 vs 5.7 ± 2.6; P = .014). Three‐dimension CMR reconstruction confirmed good correlation of the location of the islets/channels with VT exit site during electroanatomical mapping in five cases.ConclusionsThe identification and quantification of islets of heterogeneous myocardium within the scar might be useful for predicting VT in patients after MI.
piRNA‐63076 contributes to pulmonary arterial smooth muscle cell proliferation through acyl‐CoA dehydrogenase
Authors: Ma Cui , Zhang Lixin , Wang Xiaoying , He Siyu , Bai June , Li Qian , Zhang Min , Zhang Chen , Yu Xiufeng , Zhang Junting , Xin Wei , Li Yiying , Zhu Daling 
Published: March 2020

AbstractPiwi‐interacting RNAs (piRNAs) are thought to be germline‐specific and to be involved in maintaining genome stability during development. Recently, piRNA expression has been identified in somatic cells in diverse organisms. However, the roles of piRNAs in pulmonary arterial smooth muscle cell (PASMC) proliferation and the molecular mechanism underlying the hypoxia‐regulated pathological process of pulmonary hypertension are not well understood. Using hypoxic animal models, cell and molecular biology, we obtained the first evidence that the expression of piRNA‐63076 was up‐regulated in hypoxia and was positively correlated with cell proliferation. Subsequently, we showed that acyl‐CoA dehydrogenase (Acadm), which is negatively regulated by piRNA‐63076 and interacts with Piwi proteins, was involved in hypoxic PASMC proliferation. Finally, Acadm inhibition under hypoxia was partly attributed to DNA methylation of the Acadm promoter region mediated by piRNA‐63076. Overall, these findings represent invaluable resources for better understanding the role of epigenetics in pulmonary hypertension associated with piRNAs.
Increased SIX‐1 expression promotes breast cancer metastasis by regulating lncATB‐miR‐200s‐ZEB1 axis
Authors: Zhu Lizhe , Jiang Siyuan , Yu Shibo , Liu Xiaoxu , Pu Shengyu , Xie Peiling , Chen Heyan , Liao Xiaoqin , Wang Ke , Wang Bin 
Published: March 2020

AbstractPatients with advanced breast cancer (BC) showed a higher incidence of regional and distant metastases. Sine oculis homeobox homolog 1 (SIX‐1) has been confirmed to be a key tumorigenic and metastatic regulator in BC progression. Yet, molecular mechanisms behind SIX‐1‐induced BC metastases remain largely unknown. Here we found that SIX‐1 was frequently up‐regulated in BC and correlated with poor outcomes when tested in human BC tissue microarray. Then, we manipulated the expression of SIX‐1 by via shRNA‐mediated knockdown and lentivirus‐mediated overexpression. Transwell assay in vitro and lung metastases model of nude mice in vivo showed that SIX‐1 promoted BC cell invasion and migration in vitro, and facilitated metastases in vivo. Mechanistically, SIX‐1 could promote the transcription of lncATB, which exerts critical pro‐metastatic role in BC by directly binding to the miR‐200 family, especially for miR‐200c, to induce EMT and promote metastases. In conclusion, SIX‐1 exerts its pro‐metastatic role in BC through lncATB/miR‐200s axis of EMT signalling pathway and could act as an important diagnostic marker as well as a significant therapeutic target for clinically advanced BC.
Barriers to establishing shared decision‐making in childbirth: Unveiling epistemic stereotypes about women in labour
Authors: Villarmea Stella , Kelly Brenda 
Published: March 2020

AbstractRationale, aims, and objectivesThe benefits for shared decision‐making (SDM) in delivery of high‐quality and personalized care are undisputed, but what is it about the dynamics of the delivery room that leads some to doubt that true SDM is possible? How difficult can it be to establish SDM as the norm when caring for a woman in labour? The discussion around SDM, autonomy, and rationality is timely and highly relevant to wider practice.MethodThe concept of a person's autonomy in decision‐making about their body and health is generally accepted and is indeed enshrined in law in many countries. This ought to lay the foundation for SDM in obstetrics. Yet, women's experience speaks to an uncomfortable truth, namely, that it is far from commonplace. We are interested in exploring this tension between the law and the practice.ResultsWe examine a theory of female rationality and its application to women in labour, and juxtapose this with the view from the front line of care delivery. Is a woman in labour able to fully engage in an SDM process? In answering this question, associations in the discourses and practises around women's capacity during labour are revealed, which act as barriers, consciously or unconsciously, to establishing SDM as the norm in obstetrics and midwifery.Conclusion(s)The recent UN report advocating a human rights‐based approach to end mistreatment and violence against women in reproductive health services has a particular focus on childbirth and obstetric violence. This paper contributes to the recognition of obstetric violence as a human rights violation. It offers conceptual tools to diagnose the impact of gender stereotypes during childbirth and to eliminate women's discrimination in the field of reproductive health.
Associations of Social and Behavioral Determinants of Health Index with Self‐Rated Health, Functional Limitations, and Health Services Use in Older Adults
Authors: Rhee Taeho Greg , Marottoli Richard A. , Cooney Leo M. , Fortinsky Richard H. 
Published: March 2020

OBJECTIVESTo characterize the cumulative risk factors of social and behavioral determinants of health (SDoH) and examine their association with self‐rated general health, functional limitations, and use of health services among US older adults.DESIGNCross‐sectional analysis of the 2013‐2014 National Health and Nutrition Examination Survey.SETTINGNationally representative health interview survey in the United States.PARTICIPANTSSurvey respondents aged 65 or older (n = 1,306 unweighted).MEASUREMENTSA cumulative risk score of SDoH, developed by the National Academy of Medicine expert panel, was assessed using validated measures. Outcome variables included self‐rated general health, functional limitations (eg, activities of daily living), and use of health services (eg, usual source of care and overnight hospitalization). We quantified the cumulative risk score of SDoH in older adults and used multivariable‐adjusted logistic and Poisson regression analyses to assess the association of SDoH with self‐rated health, functional limitations, and use of health services, adjusting for other covariates.RESULTSAbout 25.7% of older adults, representative of 11.0 million people nationwide, reported having three or more cumulative SDoH risk factors. These older adults were more likely to have functional limitations (eg, activities of daily living) and less likely to report their general health as “very good” or “excellent” than those with two or fewer cumulative SDoH risk factors (P < .001 for each). Each additional cumulative SDoH risk factor was associated with increased odds of not having a usual source of care (adjusted odds ratio = 1.57; 95% confidence interval = 1.09‐2.27).CONCLUSIONThe SDoH index score may be a useful tool to predict access to care and quality of care in older adults. J Am Geriatr Soc 68:1731‐1738, 2020.
Hierarchical analysis of factors associated with hospital readmissions for coronary heart disease: A case–control study
Authors: de Albuquerque Nila Larisse Silva , de Araujo Thelma Leite , de Oliveira Lopes Marcos Venicios , Moreira Thereza Maria Magalhães 
Published: March 2020

AbstractAims and objectivesTo analyse, hierarchically, factors associated with hospital readmissions for acute coronary syndrome.BackgroundHospital readmissions have risen, especially in patients with multiple comorbidities, which are most often chronic. The leading causes of hospital readmission include acute coronary syndrome, which is costly and often preventable. Determining clinical and nonclinical variables that increase the chances of readmission is important to assess and evaluate patients hospitalised for coronary heart diseases.DesignA case–control study whose dependent variable was hospital readmission for acute coronary syndrome.MethodsThe study included 277 inpatients, of whom 132 were in their first hospitalisation and 145 had already been hospitalised for acute coronary syndrome. The independent variables for this hierarchical model were sociodemographic conditions, life habits, access to health services and physical health measures. Data were obtained by interviews, anthropometric measurements and patient records. Logistic regression analysis was performed using the stepwise technique, with Microsoft Excel and R version 3.2.3. The research was reported via strengthening the reporting of observational studies in epidemiology (STROBE).ResultsIn the final hierarchical logistic model, the following risk factors were associated with readmission for acute coronary syndrome: inadequate drug therapy adherence, stress, history of smoking for 30 years or more, and the lack of use of primary healthcare services.ConclusionsClinical and nonclinical variables are related to hospital readmission for acute coronary syndrome and can increase the chance of readmission by up to six times.Relevance to clinical practiceThe predictive model can be used to avoid readmission for acute coronary syndrome, and it represents an advance in the prediction of the occurrence of the outcome. This implies the need for a reorientation of the network for postdischarge care in the first hospitalisation for acute coronary syndrome.
Patient‐Reported Outcomes of Metal and Acrylic Resin Removable Partial Dentures: A Systematic Review and Meta‐Analysis
Authors: Almufleh Balqees , Emami Elham , Alesawy Aminah , Rodan Rania , Morris Martin , Umebayashi Mayumi , Tamimi Faleh 
Published: March 2020

AbstractPurposeMetal removable partial dentures (RPDs) are often considered long‐term treatment options for partially edentulous patients, while acrylic resin RPDs are considered interim treatments. The aim of this review was to compare metal and acrylic resin RPDs regarding patient‐reported outcomes for partially edentulous individuals.Materials and MethodsFour databases (MEDLINE, EMBASE, CENTRAL, and Web of Science) were systematically searched for observational studies and randomized controlled trials comparing patient‐reported outcomes between metal and acrylic resin RPDs. The primary outcome was patient satisfaction. Included studies were assessed for risk of bias using the Cochrane risk of bias in nonrandomized studies of interventions tool (ROBINS‐I) and the Cochrane Collaboration Risk of Bias Tool for Randomized Controlled Trials. The level of evidence was evaluated using Oxford Center for Evidence‐based Medicine tool. A random‐effects model was used to analyze the data.ResultsA total of 15 studies were included in the systematic review; 10 in the meta‐analysis. The pooled effect size for patient satisfaction and oral health‐related quality of life showed no statistical significant difference between metal and acrylic resin dentures (0.22, 95% confidence interval –0.01, 0.45, p = 0.06; 1.45, 95% confidence interval –2.43, 5.33, p = 0.46, respectively). Compliance with using RPDs was significantly higher in patients with metal compared to patients with acrylic resin dentures (pooled odds ratio = 0.57, 95% confidence interval 0.45, 0.73, p < 0.001). Most studies had critical to serious risk of bias and low level of evidence.ConclusionsThe reviewed studies showed that there was no significant difference between metal and acrylic resin RPDs in patient satisfaction and oral health‐related quality of life. Metal dentures were associated with higher patient compliance rates and were preferred more by patients compared to acrylic resin dentures. However, the reviewed studies had low levels of evidence and therefore, high‐quality randomized controlled trials are needed to conclusively address the question of this review.
Nonphysical Workplace Violence in a State‐Based Cohort of Education Workers*
Authors: Konda Srinivas , Tiesman Hope M. , Hendricks Scott , Grubb Paula L. 
Published: March 2020

ABSTRACTBACKGROUNDThe purpose of this study was to estimate the prevalence, identify risk factors, and assess the impact of nonphysical workplace violence (WPV) events among education workers (teachers, professionals, and support personnel).METHODSA cross‐sectional survey was mailed to a random sample of 6450 education workers, stratified by sex, occupation, and school location in Pennsylvania. Multivariable logistic regression was performed to assess risk factors.RESULTSOf the 2514 participants, 859 (34%) reported experiencing at least one nonphysical WPV event during the 2009‐2010 school year. Coworkers were the most common source of bullying. Most education workers responded that they did not receive an adequate response from their administration after reporting a nonphysical WPV event. Risks of nonphysical assaults increased for education workers who were female, those working in an urban school, and those in their first 3 years of working in their current school. Those assaulted were significantly likely to have low job satisfaction, find work more stressful, and have poor mental health compared to those were not assaulted.CONCLUSIONSAdministration support for specific prevention efforts and post‐event responses that address the risk factors for nonphysical WPV are essential for creating a positive, safe work environment in schools.
Dynamic changes in circulating levels of metabolites in the portal‐drained viscera of finishing pigs receiving acute administration of l‐arginine
Authors: Yang Jianying , Tan Bi’e , He Qinghua , Yin Yulong , Wu Guoyao , Kong Xiangfeng 
Published: March 2020

AbstractIn this study, we examined the effects of acute intravenous administration of l‐arginine on circulating levels of metabolites in the portal‐drained viscera (PDV) of 12 barrows surgically fitted with chronic catheters in the portal vein. At day 14 post‐surgery, the pigs were fasted for 12 hr and then randomly allocated to one of three groups to receive administration of normal saline, l‐alanine [103 mg/kg body weight (BW), isonitrogenous control] or l‐arginine‐HCl (61 mg/kg BW), via the portal vein. Blood samples were obtained from the carotid artery before and at 30‐min intervals for 5 hr after the administration of saline or amino acid in order to determine metabolic profiles. The results showed that, compared with the saline treatment, arginine infusion increased plasma concentrations of insulin‐like growth factor‐I, arginine and cystine in the portal vein plasma, whereas plasma concentrations of threonine, serine, leucine and methionine were reduced. These findings indicate that increasing arginine concentrations in the portal vein alters the metabolic profile in swine, an established animal model for studying human nutrition and metabolism.