bluuebunny/crossref_metadata_2025_split huggingface dataset:
R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome
Authors: Mesquita Fernanda C. P. , Arantes Paulo C. , Kasai-Brunswick Tais H. , Araujo Dayana S. , Gubert Fernanda , Monnerat Gustavo , Silva dos Santos Danúbia , Neiman Gabriel , Leitão Isabela C. , Barbosa Raiana A. Q. , Coutinho Jorge L. , Vaz Isadora M. , dos Santos Marcus N. , Borgonovo Tamara , Cruz Fernando E. S. , Miriuka Santiago , Medei Emiliano H. , Campos de Carvalho Antonio C. , Carvalho Adriana B. 
Published: December 2019

AbstractPatient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 long QT syndrome (LQTS2)-associated mutation (c.1600C > T in KCNH2, p.R534C in hERG) in CM-iPSC. Peripheral blood mononuclear cells were isolated from two patients with the R534C mutation and iPSCs were generated. In addition, the same mutation was inserted in a control iPSC line by genome editing using CRISPR/Cas9. Cells expressed pluripotency markers and showed spontaneous differentiation into the three embryonic germ layers. Electrophysiology demonstrated that action potential duration (APD) of LQTS2 CM-iPSC was significantly longer than that of the control line, as well as the triangulation of the action potentials (AP), implying a longer duration of phase 3. Treatment with the IKr inhibitor E4031 only caused APD prolongation in the control line. Patch clamp showed a reduction of IKr on LQTS2 CM-iPSC compared to control, but channel activation was not significantly affected. Immunofluorescence for hERG demonstrated perinuclear staining in LQTS2 CM-iPSC. In conclusion, CM-iPSC recapitulated the LQTS2 phenotype and our findings suggest that the R534C mutation in KCNH2 leads to a channel trafficking defect to the plasma membrane.
Localizing the γ-ray emitting region in the blazar TXS 2013+370
Authors: Traianou E. , Krichbaum T. P. , Boccardi B. , Angioni R. , Rani B. , Liu J. , Ros E. , Bach U. , Sokolovsky K. V. , Lisakov M. M. , Kiehlmann S. , Gurwell M. , Zensus J. A. 
Published: December 2019

Aims. The γ-ray production mechanism and its localization in blazars are still a matter of debate. The main goal of this paper is to constrain the location of the high-energy emission in the blazar TXS 2013+370 and to study the physical and geometrical properties of the inner jet region on sub-pc scales.
Methods. TXS 2013+370 was monitored during 2002–2013 with VLBI at 15, 22, 43, and 86 GHz, which allowed us to image the jet base with an angular resolution of ≥0.4 pc. By employing CLEAN imaging and Gaussian model-fitting, we performed a thorough kinematic analysis at multiple frequencies, which provided estimates of the jet speed, orientation, and component ejection times. Additionally, we studied the jet expansion profile and used the information on the jet geometry to estimate the location of the jet apex. VLBI data were combined with single-dish measurements to search for correlated activity between the radio, mm, and γ-ray emission. For this purpose, we employed a cross-correlation analysis, supported by several significance tests.
Results. The high-resolution VLBI imaging revealed the existence of a spatially bent jet, described by co-existing moving emission features and stationary features. New jet features, labeled as A1, N, and N1, are observed to emerge from the core, accompanied by flaring activity in radio/mm- bands and γ-rays. The analysis of the transverse jet width profile constrains the location of the mm core to lie ≤2 pc downstream of the jet apex, and also reveals the existence of a transition from parabolic to conical jet expansion at a distance of ∼54 pc from the core, corresponding to ∼1.5 × 106 Schwarzschild radii. The cross-correlation analysis of the broad-band variability reveals a strong correlation between the radio-mm and γ-ray data, with the 1 mm emission lagging ∼49 days behind the γ-rays. Based on this, we infer that the high energy emission is produced at a distance of the order of ∼1 pc from the jet apex, suggesting that the seed photon fields for the external Compton mechanism originate either in the dusty torus or in the broad-line region.
Ceres’ partial differentiation: undifferentiated crust mixing with a water-rich mantle
Authors: Neumann Wladimir , Jaumann Ralf , Castillo-Rogez Julie , Raymond Carol A. , Russell Christopher T. 
Published: December 2019

Aims.We model thermal evolution and water-rock differentiation of small ice-rock objects that accreted at different heliocentric distances, while also considering migration into the asteroid belt for Ceres. We investigate how water-rock separation and various cooling processes influence Ceres’ structure and its thermal conditions at present. We also draw conclusions about the presence of liquids and the possibility of cryovolcanism.Methods.We calculated energy balance in bodies heated by radioactive decay and compaction-driven water-rock separation in a three-component dust-water/ice-empty pores mixture, while also taking into consideration second-order processes, such as accretional heating, hydrothermal circulation, and ocean or ice convection. Calculations were performed for varying accretion duration, final size, surface temperature, and dust/ice ratio to survey the range of possible internal states for precursors of Ceres. Subsequently, the evolution of Ceres was considered in five sets of simulated models, covering different accretion and evolution orbits and dust/ice ratios.Results.We find that Ceres’ precursors in the inner solar system could have been both wet and dry, while in the Kuiper belt, they retain the bulk of their water content. For plausible accretion scenarios, a thick primordial crust may be retained over several Gyr, following a slow differentiation within a few hundreds of Myr, assuming an absence of destabilizing impacts. The resulting thermal conditions at present allow for various salt solutions at depths of ≲10 km. The warmest present subsurface is obtained for an accretion in the Kuiper belt and migration to the present orbit.Conclusions.Our results indicate that Ceres’ material could have been aqueously altered on small precursors. The modeled structure of Ceres suggests that a liquid layer could still be present between the crust and the core, which is consistent with Dawn observations and, thus, suggests accretion in the Kuiper belt. While the crust stability calculations indicate crust retention, the convection analysis and interior evolution imply that the crust could still be evolving.
Rydberg excitons in electric and magnetic fields obtained with the complex-coordinate-rotation method
Authors: Zielinski Patrik , Rommel Patric , Schweiner Frank , Main Jörg 
Published: December 2019

Abstract
The complete theoretical description of experimentally observed magnetoexcitons in cuprous oxide has been achieved by Schweiner et al (2017 Phys. Rev. B 95 035202), using a complete basis set and taking into account the valence band structure and the cubic symmetry of the solid. Here, we extend these calculations by investigating numerically the autoionising resonances of cuprous oxide in electric fields and in parallel electric and magnetic fields oriented in [001] direction. To this aim we apply the complex-coordinate-rotation method. Complex resonance energies are computed by solving a non-Hermitian generalised eigenvalue problem, and absorption spectra are simulated by using relative oscillator strengths. The method allows us to investigate the influence of different electric and magnetic field strengths on the position, the lifetime, and the shape of resonances.
Achieving extremely high optical contrast of atomically-thin MoS2
Authors: Donnelly Gavin E , Velický Matěj , Hendren William R , Bowman Robert M , Huang Fumin 
Published: December 2019

Abstract
Extraordinarily high optical contrast is instrumental to research and applications of two-dimensional materials, such as, for rapid identification of thickness, characterisation of optical properties, and quality assessment. With optimal designs of substrate structures and light illumination conditions, unprecedented optical contrast of MoS2 on Au surfaces exceeding 430% for monolayer and over 2600% for bilayer is achieved. This is realised on custom-designed substrates of near-zero reflectance near the normal incidence. In particular, by using an aperture stop to restrict the angle of incidence, high-magnification objectives can be made to achieve extraordinarily high optical contrast in a similar way as the low-magnification objectives, but still retaining the high spatial resolution capability. The technique will allow small flakes of micrometre size to be located easily and identified with great accuracy, which will have significant implications in many applications.
Risk assestment of housing reconstruction project community-based construction after the earthquake
Authors: Boy Wendi , Imani Rafki , Chari Mayozi , Purba Widiawati , Melasari Jihan 
Published: December 2019

Abstract
Earthquake events caused thousands of families to be displaced, some inside refugee camps, others living in relatives’ houses, besides causing the stages of government, economy and Social Stage to experience many obstacles. Reconstruction implementation Community-based housing is the backbone for sustainable development. Through this approach, it is hoped that people can realize the importance of building a building using earthquake resistant building structures. Based Deskriftive analysis and factor analysis, there are 18 (eighteen) the risk of pre-construction project of housing reconstruction after the earthquake based society including the risk of unexpected (Undesirable). From 8 (eight) Stages of pre-construction phase of the housing reconstruction is 1 (One) Stages of risks are still acceptable namely Stages 6 (Stages of Establishment of Community Organizations). The greatest risk is in Stage 8 is R.8.16. The price of Building Materials which has the biggest risk value is: 5.389. With this risk analysis it is hoped that the parties concerned can pay more attention to the risks that have high value (categorized as an unexpected risk)”.
Decision Support System in Determining Structural Position Mutations Using Simple Additive Weighting (SAW) Method
Authors: Fitrul Hadi Aulia , Permana Randy , Syafwan Havid 
Published: December 2019

AbstractMutations are needed in a company to improve the quality of workers. mutations are based on the capabilities of individual workers in the company. HRD assesses the abilities of workers from various aspects. manually the accuracy of mutations based on the value of the criteria is only 38%. with a low value of accuracy resulting in mutations of workers not as expected. the criteria given are FFB Production (C1), Core CPO Production (C2) and Field Care (C3). Range of mutation decision weights are 10-30% Giving First Warning Letter, 31 - 70% Position setting and 71 - 100% Giving promotion. with the SAW method the analysis is done by computerization. after testing the criteria obtained. HRD assesses that the accuracy of workers reaches 85%. and better and in accordance with what the company wants.
Exploring Topic Difficulty in Information Retrieval Systems Evaluation
Authors: Ting Pang Wei , Rajagopal Prabha , Wang Mengjia , Zhang Shuxiang , Devi Ravana Sri 
Published: December 2019

Abstract
Experimental or relevance assessment cost as well as reliability of an information retrieval (IR) evaluation is highly correlated to the number of topics used. The need of many assessors to produce equivalent large relevance judgments often incurs high cost and time. So, large number of topics in retrieval experiment is not practical and economical. This experiment proposes an approach to identify most effective topics in evaluating IR systems with regards to topic difficulty. The proposed approach is capable of identifying which topics and topic set size are reliable when evaluating system effectiveness. Easy topics appeared to be most suitable for effectively evaluating IR systems.
Application of AHP Analysis to Increase Employee Career Paths in Decision Support Systems
Authors: Santony Julius , Amir Faisal , Sumijan  , Novita Rice 
Published: December 2019

Abstract
Employee career paths are one way for companies to improve employee performance in educating their students. The problem of manager in decision making uses the selection of methods and assessment processes subjectively so that the process is not in accordance with the goals of the career path. Therefore, an Analytical Hierarchy Process (AHP) method is needed to help make decisions. In this study, using the criteria of Planning, Teaching, Evaluating and Learning. Ranking results obtained that Learning criteria are very important criteria with calculation results of 0.602 when compared to the other three criteria. The Decision Support System (DSS) application provides the final results obtained from testing the calculation that the alternative Employee C is the best employee with a calculation of 0.227 compared to the other alternatives. The DSS application using the AHP method has a data accuracy rate of 86.67% and can be used as a support for manager decisions to make recommendations for increasing employee career paths.
Online Management System of UPI FKIP YPTK Padang Education Field Practice
Authors: Indah Juwita Astri , Ikhlas Muhammad 
Published: December 2019

Abstract
This study aims to develop the management system of PLK in the form of online system based on FKIP UPI YPTK Padang website that is valid, practical and effective. This is because there is no special system to accommodate PLK implementation process as PLK’s online management system. The type of research that the authors use is Research and Development research better known as R & D. System test conducted on students at FKIP Prodi PTI UPI YPTK Padang. The test subjects consisted of the validity aspect of the system performed on 3 validators (expert), and the media practicality aspect that was done on 1 practitioner and 35 students who did the PLK. Instruments used in collecting data in the form of questionnaires of validity and practicality, and effectiveness. The data analysis techniques use Aiken’s V formula to find validity and calculate practicality percentages for practicality and use factor analysis techniques to search for the effectiveness of a website-based online management system. Based on the research that has been done, then obtained online management system based website PLK is www.fkipupiyptk.com, with validity value 0.80 Valid stated. While the average practicable result practiced by practitioners is 97.00% and is categorized as very practical, and the practical average by PLK students is 86.11% with very practical category. Effectiveness seen from the paired sample test t test, obtained a significance value of 0, 000 (0, 000 <0, 05) means that there are significant differences in students who use manual systems with students who use the online system, thus the PLK online management system website is effective to use compared to the system manual.
Determination of the Shortest Route Towards the Tourist Destination Area Using the Ant Algorithma
Authors: Wiwik Sri Rahayu Ginantra Ni Luh , Taufiqurrahman T , Widi Bhawika Gita , Bagus Ary Indra Iswara Ida , Wanto Anjar 
Published: December 2019

Abstract
There are so many tourism objects in the world, especially in Indonesia. One of the most famous tourist attractions in Indonesia including Bali, Borobudur, Lake Toba, and many others. The tourist attraction is not only famous in Indonesia but also famous to foreign countries, because one of them is a relic of the wonders of the world. In addition, these tourist attractions also have natural beauty and uniqueness, which is different from other countries, so that it attracts local tourists and foreign tourists to visit the place. However, there are several routes to get to these tourist attractions, so that local tourists and foreign tourists who want to visit have a little trouble having to go through which route to get to their destination. Surely they want the closest travel route. Therefore the purpose of this study is to use the ant algorithm to determine the shortest route to the tourist area. The ant algorithm is adopted based on the behavior and habits of the ant colony. In general, ant colonies can find and find the fastest and shortest route or route to food sources from their nests, based on footprints on traversed trails. This study uses 5 cities for example, including C1, C2, C3, C4 and C5, with the starting point of C1 and C5 destination point. Based on calculations using the ant algorithm to determine the shortest route, the shortest and fastest route obtained by ant 4 is route C1 → C4 → C5 with a distance of 140 KM.
TweetGST: A Web Based Systems for Sentiment Analysis and Opinion Mining for GST in Malaysia
Authors: Misyani Mohd Rafie Nurul , Dewi Varathan Kasturi , Shafenoor Amin Mohammad 
Published: December 2019

Abstract
Twitter is one of the most used platform for communication by people around the world. Sentiment analysis and opinion mining on twitter has become an important field of research that sees beyond the number of likes, shares and comments that users have for some topics. Nowadays, business organizations are not aware of emotional aspect of their customers and may take longer time in analyzing the market sentiment in making the necessary business decision. TweetGST is a web based system that enable business user to extract GST based tweets from Twitter as well as it helps in analyzing the tweets accordingly. TweetGST enables for trend analysis and sentiment analysis to be made. These analysis will help the business organization in order to understand customer sentiment and provide for their needs. The analyzed tweets will be used in helping the business organization to make the right decision which are recommendation for sales and stocks. Thus, TweetGST is expected to increase the revenue of the businesses.
Radiation Pattern Reconfigurable FM Antenna
Authors: Bharath Gopalakrishnan Jaya , Sabapathy Thennarasan , Jusoh Muzammil , Al-Bawri Samir , Yaasin M.N. , Nasrun Osman Mohamed , Abd Rahim Hasliza , Hafizudin Mat Mohd , Majid Huda A. , Ali Tarmizi , Abdul Wahab Yasmin 
Published: December 2019

Abstract
In this work, a radiation pattern reconfigurable antenna design using compact printed spiral monopoles that operates at 102 MHz is reported. The proposed antenna changes its radiation behaviour that responds towards a desired direction with the use of RF switches. The antenna is printed on a 76.6mm × 50mm PCB layer providing more than 20MHz bandwidth at -10 dB threshold and is easily fabricated with low manufacturing cost. The antenna was also simulated on 500mm × 500mm ground plane that represents the roof top of a vehicle.
Using 3D Media to Improve Short Stories Writing Skill on Junior High School Students
Authors: Khaerunnisa  , Mutiarani  , Soviana Devi Wika , Irma Sarjani Andi 
Published: December 2019

Abstract
The writers conducted this research as the result of field observation that found the students’ short stories writing skill are still poor. The purpose of this research is to improve short stories writing skill through three dimensional media of the students in the class IX SMPLB A Tan Miyat, Bekasi, West Java. The research method used in this research is Classroom Action Research method. This research was conducted for two months December to January for two cycles and in each cycle held in two meetings. Learning activities in short stories writing using three-dimensional media is expected that students will be easier to develop creativity and imagination in making a short story. The results of this study show that using three-dimensional media can improve the ability to write short stories. This findings of the research are the data obtained during pre-cycle is only 30%. After implementing the three dimensional media towards write short stories writing, the students’ short stories writing skill have increased. In the first cycle, the students’ short stories writing increased 50%, and on the second cycle improved into to 95%. The increasing of the students’ short stories writing skill will also improve the quality of language learning especially in the creative writing skill.
Convergence Analysis of Acceleration and Generalization of E-Learning in the Manifestation of Globalization Education Readiness 4.0
Authors: Rizki Mulyani Sitti , Ramadhanu Agung , Permata Sari Desi , Husna Arsyah Rahmatul , Sri Wahyuni Nengsih Neni 
Published: December 2019

Abstract
Education 4.0 is an education characterized by the use of digital technology in the learning process or known as a cyber system. In its implementation, online learning or what we know as e-learning today really determines the quality of education in every nation and country, coupled with the entry of the industrial era 4.0 which must manifest globalization learning without any limits, both in terms of time, distance, and cost. Utilization of E-learning will have a good impact on education. As a form of expression of online learning, the research team from the Putra Indonesia University YPTK Padang institution has implemented an online lecture system, facilitated by the Learning Management System (LMS) in the form of the Moodle Application. This research was conducted at Putra Indonesia University YPTK Padang with a population of all active students, while for a sample of 381 people, the sampling technique was Propotional Random Sampling using Slovin formula. As for the output of the results of this study, among others, it can be a reference material for accredited national journals and scopus. While the impact of the outcome of the research results will be referred to as a role model in online learning.
Digital Life Society Education from Punakawan History
Authors: Capellita M B , Lestari N S 
Published: December 2019

Abstract
This study discusses the technique of diluting the tense atmosphere in society in one case of social life. The focus of this research is traditional strategies that are still used to reduce tension in the social life of the community. The purpose of this study is to dismantle cultural heritage that is very valuable but often less understood by other people due to the use of different language and cultural codes. This study uses a qualitative research paradigm procedure. The results of the study showed that the technique of reducing tension by using the characters in the wayang stories was considered very effective. The role of the clownman becomes a figure that attracts attention. The technique used is the character, physically it must be imperfect which means inviting a smile and not in a simple social position but having a very strong influence. These characters are also very familiar with the background of the social life of the community in everyday life. This strategy is in the background of the attitude and behavior of Javanese people who do have two poles. On the one hand, Javanese people have a strong attitude, but on the other hand, they also have a very loose attitude. Javanese people use clowns which are certain characters, which are considered as strategic characters to reduce the situation of very high tension. Techniques to reduce the peak tension situation do need special expertise. This condition is indeed not easy because it has to be in all walks of life through the right language of communication.