bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain function distinguishes female carriers and non-carriers of familial risk for autism
Authors: Eggebrecht Adam T. , Dworetsky Ally , Hawks Zoë , Coalson Rebecca , Adeyemo Babatunde , Davis Savannah , Gray Daniel , McMichael Alana , Petersen Steven E. , Constantino John N. , Pruett John R. 
Published: October 2020

Abstract
Background
Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sample identified neural signatures of familial risk elicited by passive viewing of point light motion displays, suggesting the possibility that both resilience and risk of autism might be associated with brain responses to biological motion. To confirm a relationship between these signatures and inherited risk of autism, we tested them in families enriched for genetic loading through undiagnosed (“carrier”) females.

Methods
Using functional magnetic resonance imaging, we examined brain responses to passive viewing of point light displays—depicting biological versus non-biological motion—in a sample of undiagnosed adult females enriched for inherited susceptibility to ASD on the basis of affectation in their respective family pedigrees. Brain responses in carrier females were compared to responses in age-, SRS-, and IQ-matched non-carrier-females—i.e., females unrelated to individuals with ASD. We conducted a hypothesis-driven analysis focused on previously published regions of interest as well as exploratory, brain-wide analyses designed to characterize more fully the rich responses to this paradigm.

Results
We observed robust responses to biological motion. Notwithstanding, the 12 regions implicated by prior research did not exhibit the hypothesized interaction between group (carriers vs. controls) and point light displays (biological vs. non-biological motion). Exploratory, brain-wide analyses identified this interaction in three novel regions. Post hoc analyses additionally revealed significant variations in the time course of brain activation in 20 regions spanning occipital and temporal cortex, indicating group differences in response to point light displays (irrespective of the nature of motion) for exploration in future studies.

Limitations
We were unable to successfully eye-track all participants, which prevented us from being able to control for potential differences in eye gaze position.

Conclusions
These methods confirmed pronounced neural signatures that differentiate brain responses to biological and scrambled motion. Our sample of undiagnosed females enriched for family genetic loading enabled discovery of numerous contrasts between carriers and non-carriers of risk of ASD that may index variations in visual attention and motion processing related to genetic susceptibility and inform our understanding of mechanisms incurred by inherited liability for ASD.
Predicting in silico electron ionization mass spectra using quantum chemistry
Authors: Wang Shunyang , Kind Tobias , Tantillo Dean J. , Fiehn Oliver 
Published: October 2020

AbstractCompound identification by mass spectrometry needs reference mass spectra. While there are over 102 million compounds in PubChem, less than 300,000 curated electron ionization (EI) mass spectra are available from NIST or MoNA mass spectral databases. Here, we test quantum chemistry methods (QCEIMS) to generate in silico EI mass spectra (MS) by combining molecular dynamics (MD) with statistical methods. To test the accuracy of predictions, in silico mass spectra of 451 small molecules were generated and compared to experimental spectra from the NIST 17 mass spectral library. The compounds covered 43 chemical classes, ranging up to 358 Da. Organic oxygen compounds had a lower matching accuracy, while computation time exponentially increased with molecular size. The parameter space was probed to increase prediction accuracy including initial temperatures, the number of MD trajectories and impact excess energy (IEE). Conformational flexibility was not correlated to the accuracy of predictions. Overall, QCEIMS can predict 70 eV electron ionization spectra of chemicals from first principles. Improved methods to calculate potential energy surfaces (PES) are still needed before QCEIMS mass spectra of novel molecules can be generated at large scale.
Regional robust secure precise wireless transmission design for multi-user UAV broadcasting system
Authors: Shen Tong , Liu Tingting , Lin Yan , Wu Yongpeng , Shu Feng , Han Zhu 
Published: October 2020

AbstractIn this paper, two regional robust secure precise wireless transmission (SPWT) schemes for multi-user unmanned aerial vehicle (UAV), (1)regional signal-to-leakage-and-noise ratio (SLNR) and artificial-noise-to-leakage-and-noise ratio (ANLNR) (R-SLNR-ANLNR) maximization and (2) point SLNR and ANLNR (P-SLNR-ANLNR) maximization, are proposed to tackle with the estimation errors of the target users’ location. In the SPWT system, the estimation error for SPWT cannot be ignored. However, the conventional robust methods in secure wireless communications optimize the beamforming vector in the desired positions only in statistical means and cannot guarantee the security for each symbol. The proposed regional robust schemes are designed for optimizing the secrecy performance in the whole error region around the estimated location. Specifically, with the known maximal estimation error, we define the target region and wiretap region. Then, we design an optimal beamforming vector and an artificial noise projection matrix, which achieve the confidential signal in the target area having the maximal power while only few signal power is conserved in the potential wiretap region. Instead of considering the statistical distributions of the estimated errors into optimization, we optimize the SLNR and ANLNR of the whole target area, which significantly decreases the complexity. Moreover, the proposed schemes can ensure that the desired users are located in the optimized region, which are more practical than the conventional methods. Simulation results show that our proposed regional robust SPWT design is capable of substantially improving the secrecy rate compared to the conventional non-robust method. The P-SLNR-ANLNR maximization-based method has the comparable secrecy performance with lower complexity than that of the R-SLNR-ANLNR maximization-based method.
Stress of Conscience Questionnaire (SCQ): exploring dimensionality and psychometric properties at a tertiary hospital in Australia
Authors: Jokwiro Yangama , Pascoe Elizabeth , Edvardsson Kristina , Rahman Muhammad Aziz , McDonald Ewan , Lood Qarin , Edvardsson David 
Published: October 2020

Abstract
Background
This study explored the psychometric properties and dimensionality of the Stress of Conscience Questionnaire (SCQ) in a sample of health professionals from a tertiary-level Australian hospital. The SCQ, a measure of stress of conscience, is a recently developed nine-item instrument for assessing frequently encountered stressful situations in health care, and the degree to which they trouble the conscience of health professionals. This is relevant because stress of conscience has been associated with negative experiences such as job strain and/or burnout. The validity of SCQ has not been explored beyond Scandinavian contexts.

Methods
A cross-sectional study of 253 health professionals was undertaken in 2015. The analysis involved estimates of reliability, variability and dimensionality. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to explore dimensionality and theoretical model fit respectively.

Results
Cronbach’s alpha of 0.84 showed internal consistency reliability. All individual items of the SCQ (N = 9) met the cut-off criteria for item-total correlations (> 0.3) indicating acceptable homogeneity. Adequate variability was confirmed for most of the items, with some items indicating floor or ceiling effects. EFA retained a single latent factor with adequate factor loadings for a unidimensional structure. When the two‐factor model was compared to the one‐factor model, the latter achieved better goodness of fit supporting a one-factor model for the SCQ.

Conclusion
The SCQ, as a unidimensional measure of stress of conscience, achieved adequate reliability and variability in this study. Due to unidimensionality of the tool, summation of a total score can be a meaningful way forward to summarise and communicate results from future studies, enabling international comparisons. However, further exploration of the questionnaire in other cultures and clinical settings is recommended to explore the stability of the latent one-factor structure.
Enhanced differentiation of isomeric RNA modifications by reducing the size of ions in ion mobility mass spectrometric measurements
Authors: Wang Hongzhou , Todd Daniel A. , Chiu Norman H. L. 
Published: October 2020

AbstractWith the ability to differentiate different molecular sizes, ion mobility spectrometry (IMS) has great potentials in the analysis of isomeric compounds. However, due to the lack of sensitivity and resolution, IMS has not been commonly used. To address the issue on resolution, the goals of this study are to explore a more effective way to perform IMS by reducing the size of ions prior to the IM measurements, and apply the new approach to the differentiation of isomeric RNA modifications. The size reduction of ribonucleoside ions was effectively accomplished by using the collision-induced dissociation process, in which the N-glycosidic bond in ribonucleoside was cleaved and split the ions into two parts—a smaller nucleobase ion and a neutral molecule of ribose sugar. Since the chemical group that corresponds to most of the RNA modifications makes up a relatively small part of the molecular structure of nucleobases, the differentiation of the dissociated nucleobase ions is expected to require a lower ion mobility resolution than the differentiation of bigger isomeric ribonucleoside ions. By using RNA methylation as a model in this study, the proposed method lowered the required resolution by 16% for the differentiation of 1-methyladenosine and N6-methyladenosine. Similar results were also obtained from the differentiation of methylated cytidine isomers. In comparison to the results obtained from using the conventional tandem mass spectrometric method, there was no significant loss of signals when the proposed method was used. The proposed method is expected to be applicable to other types of isomeric compounds. Also, the same approach is applicable on other IMS platforms.
Recent advances in applications of multimodal ultrasound-guided photoacoustic imaging technology
Authors: Wang Shanshan , Zhao Yunfeng , Xu Ye 
Published: October 2020

AbstractPhotoacoustic imaging (PAI) is often performed simultaneously with ultrasound imaging and can provide functional and cellular information regarding the tissues in the anatomical markers of the imaging. This paper describes in detail the basic principles of photoacoustic/ultrasound (PA/US) imaging and its application in recent years. It includes near-infrared-region PA, photothermal, photodynamic, and multimode imaging techniques. Particular attention is given to the relationship between PAI and ultrasonic imaging; the latest high-frequency PA/US imaging of small animals, which involves not only B-mode, but also color Doppler mode, power Doppler mode, and nonlinear imaging mode; the ultrasonic model combined with PAI, including the formation of multimodal imaging; the preclinical imaging methods; and the most effective detection methods for clinical research for the future.
A sharp-interface immersed boundary method for simulating high-speed compressible inviscid flows
Authors: Wang Junjie , Gu Xiangyu , Wu Jie 
Published: October 2020

AbstractThis paper presents a robust sharp-interface immersed boundary method for simulating inviscid compressible flows over stationary and moving bodies. The flow field is governed by Euler equations, which are solved by using the open source library OpenFOAM. Discontinuities such as those introduced by shock waves are captured by using Kurganov and Tadmor divergence scheme. Wall-slip boundary conditions are enforced at the boundary of body through reconstructing flow variables at some ghost points. Their values are obtained indirectly by interpolating from their mirror points. A bilinear interpolation is employed to determine the variables at the mirror points from boundary conditions and flow conditions around the boundary. To validate the efficiency and accuracy of this method for simulation of high-speed inviscid compressible flows, four cases have been simulated as follows: supersonic flow over a 15 ° angle wedge, transonic flow past a stationary airfoil, a piston moving with supersonic velocity in a shock tube and a rigid circular cylinder lift-off from a flat surface triggered by a shock wave. Compared to the exact analytical solutions or the results in literature, good agreement can be achieved.
Refractory axillary venous spasm during permanent pacemaker implantation
Authors: Vemuri Krishna Santosh , Parashar Nitin , Bootla Dinakar , Revaiah Pruthvi C. , Kanabar Kewal , Nevali Krishna Prasad , Sharma Yash Paul , Kasinadhuni Ganesh , Panda Prashant 
Published: October 2020

Abstract
Background
Vascular spasm is well known to occur in the arterial system. Central venous spasm during pacemaker implantation is uncommon with only a few cases reported from time to time. Sometimes, the venous spasms may not respond to nitroglycerine injections which requires a change of access site and undue discomfort for the patient.

Case presentation
A 72-year-old female patient with no prior comorbidities presented to us with recurrent dizziness on exertion and at rest. The electrocardiogram showed complete heart block, likely to be of sclerodegenerative etiology as the patient did not have any ischemic symptoms, also the electrocardiogram and echocardiogram did not show any evidence of ischemia. As part of the hospital protocol, a venogram was performed by giving intravenous diluted contrast (iohexol) through the left brachial vein, which showed good-sized axillary and subclavian veins. We attempted to cannulate the left axillary vein with a 16G needle using Seldinger technique, but the axillary vein could not be cannulated despite multiple attempts. We gave incremental boluses of intravenous nitroglycerine, despite that the left axillary vein could not be cannulated. Repeat intravenous contrast injection showed severe spasm of axillary and subclavian veins. Finally, the axillary vein was cannulated from the right side using anatomical landmarks and a pacemaker was implanted.

Conclusions
Venous spasm during device implantation although uncommon, it should be anticipated in patients with difficult cannulation to prevent inadvertent complications like pneumothorax and arterial injuries. Mild venous spasm may relieve with time but severe venous spasm may require a change of access site
Pulmonary emphysema and atherosclerosis: association or syndrome?
Authors: Elrefai Atef W. , Alsayyad Mohammad Mossaad , Dawood Elsayed Mohamed Abd El-Hamid Hassan 
Published: October 2020

AbstractBackgroundAtherosclerosis is an inflammatory reaction of the vessel wall. Emphysema may induce systemic inflammation, part of which may be the development or progression of atherosclerosis. So, the relationship between emphysema and atherosclerosis, whether both are due to the same causative agent and pathogenesis or emphysema led to atherosclerosis, is still not clearly understood. So, the aim of this work is to study the relationship between carotid atherosclerosis versus pulmonary emphysema extent and airflow obstruction.ResultsCigarette smoking index was higher in patients than controls. According to FEV1%, patients were classified into: GOLD 1 (mild): FEV1 ≥ 80% predicted, GOLD 2 (moderate): 50% ≤ FEV1 < 80% predicted, GOLD 3 (severe):30% ≤ FEV1 < 50% predicted, and GOLD 4 (very severe): FEV1 < 30% predicted. There was a significant difference between the studied groups as regard to ABG parameters. Emphysema score showed a positive correlation with thrombus size, plaque size, and stenosis percent. Approximately 2/3 of patients had atherosclerotic changes and the other 1/3 had increased IMT. GOLD staging, also, correlated with thrombus size and stenosis percent. So, there was a strong positive correlation between both emphysema score and GOLD staging and carotid atherosclerosis.ConclusionThe relationship between emphysema and atherosclerosis is suggested to be the chronic inflammatory reaction (against the same risk factor) based on the positive correlation between carotid atherosclerosis versus emphysema score and GOLD staging. The inherence of emphysema and atherosclerosis may be considered a syndrome. If so, targeting the same pathogenic mechanism will be valuable for their control.
Molecular Imaging Targeting Corticotropin-releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm
Authors: Walia Rama , Gupta Rahul , Bhansali Anil , Pivonello Rosario , Kumar Rajender , Singh Harmandeep , Ahuja Chirag , Chhabra Rajesh , Singh Apinderpreet , Dhandapani Sivashanmugam , Sahoo Sushant , Rana Nivedita , Vatsa Rakhee , Dutta Pinaki , Kumar Bhadada Sanjay , Sachdeva Naresh , Mittal B R , Nahar Uma , Shukla Jaya 
Published: October 2020

Abstract

Background
Corticotrophin-releasing hormone (CRH) is the major regulator of adrenocorticotrophic hormone (ACTH) secretion from the anterior pituitary and acts via CRH-1 receptors (CRH-1R). Corticotropinoma though autonomous, still retain their responsiveness to CRH and hence, we hypothesize that in vivo detection of CRH-1 receptors on pituitary adenoma using Gallium-68 (68Ga)-tagged CRH can indicate the functionality of adenoma, and combining it with positron emission tomography-computed tomography (PET-CT) can provide requisite anatomical information.

Methods
Subjects with ACTH-dependent Cushing’s syndrome (CS) (n = 27, 24 with Cushing’s disease [CD], 3 with ectopic CS [ECS]) underwent 68Ga CRH PET-CT. Two nuclear medicine physicians read these images for adenoma delineation and superimposed them on magnetic resonance imaging (MRI) sella. The information provided was used for intraoperative navigation and compared with operative and histopathological findings.

Findings
68Ga CRH PET-CT correctly delineated corticotropinoma in all the 24 cases of CD, including the 10 cases with adenoma size &lt; 6mm (4 cases were negative on MRI). Corticotropinoma location on 68Ga CRH PET fusion images with MRI were concordant with operative findings and were further confirmed on histopathology. There was no tracer uptake in the pituitary in 2 patients with ECS, while, in another, the diffuse uptake in pituitary suggested ectopic CRH production.

Conclusion
68Ga CRH PET-CT represents a novel, noninvasive molecular imaging, targeting CRH receptors that not only delineate corticotropinoma and provides the surgeon with valuable information for intraoperative tumor navigation, but also helps in differentiating a pituitary from an extra-pituitary source of ACTH-dependent CS.

Funding
None.
Standards of Cultural Behaviour of the Romans in the Light of Sidonius Apollinaris' Letters
Authors: Styka Jerzy 
Published: October 2020

Standards of Cultural Behaviour of the Romans in the Light of Sidonius Apollinaris' Letters
The cultural and political situation of the Gallo-Roman elite in the 5th century CE, during the period of the great barbarian invasions, became the reason for the emergence, among its members, of certain standards of behaviour; their aim was to preserve, cultivate and develop the Roman identity as well as a sense of belonging to the elite cultural circle, now endangered by barbaric chaos. The paper presents selected examples of such standards of behaviour in spheres both private and public; they serve as an exemplification of conscious actions and choices designed to preserve traditional Roman system of values
Do Individual Investors Trade on Investment-Related Internet Postings?
Authors: Ammann Manuel , Schaub Nic 
Published: October 2020

Many people share investment ideas online. This study investigates whether individual investors trade on investment-related internet postings. We use unique data from a social trading platform that allow us to observe the shared portfolios of traders, their posted comments, and the replicating transactions of followers. We find robust evidence that followers increasingly replicate shared portfolios of traders after the posting of comments. However, postings do not help followers identify portfolios that deliver superior performance in the future. In a cross-sectional analysis, we show that it is mainly followers typically considered to be unsophisticated who trade after comment postings. This paper was accepted by Tyler Shumway, finance.
Digitally enhanced molecular dispersion spectroscopy
Authors: Wong Justin , Bandutunga Chathura P. , Zhang Ya , Gray Malcolm B. , Chow Jong H. 
Published: October 2020

A frequency and intensity noise immune fiber dispersion spectrometer with a digitally enhanced homodyne phase extraction system is presented. A hydrogen cyanide (

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EDITORIAL: 2017-2020 A Jornada Valeu a Pena!
Authors: Nassif Vânia Maria Jorge 
Published: October 2020

Gratidão pela oportunidade e pela confiança a mim atribuída na função de Editora-Chefe da REGEPE - Revista de Empreendedorismo e Gestão de Pequenas Empresas de 2017 a 2020. Foram quatro anos de muito trabalho, desafios, aprendizagem, renúncia, mas também de satisfação por fazer parte da evolução e dos impactos que a REGEPE trouxe para a comunidade científica. Para superar os desafios, compartilhei todos os momentos, tanto os prazerosos como os difíceis, com pessoas inspiradoras a quem sou muito agradecida.
An Evolutionary Medicine Perspective on Treatment of Pediatric Functional Abdominal Pain
Authors: Leontiadis Grigorios I. , Longstreth George F. 
Published: October 2020

Abstract
In a recent issue, Kovacic et al. analyze data from a randomized sham-controlled trial and show that pretreatment vagal efficiency, an index related to respiratory sinus arrhythmia, is a predictor of pain improvement in adolescents with functional abdominal pain when treated with auricular percutaneous electrical nerve field stimulation. The underlying premise is the polyvagal hypothesis, an explanatory framework for the evolution of the mammalian autonomic nervous system, which proposes that functional gastrointestinal disorders can result from a chronic maladaptive state of autonomic neural control mechanisms after traumatic stress. This is an opportunity for us to stimulate physicians’ interest in evolutionary medicine.
Constacyclic and Linear Complementary Dual Codes Over Fq + uFq
Authors: Prakash Om , Yadav Shikha , Verma Ram Krishna 
Published: October 2020

This article discusses linear complementary dual (LCD) codes over ℜ = Fq+uFq(u2=1) where q is a power of an odd prime p. Authors come up with a new Gray map from ℜn to F2nq and define a new class of codes obtained as the gray image of constacyclic codes over .ℜ Further, we extend the study over Euclidean and Hermitian LCD codes and establish a relation between reversible cyclic codes and Euclidean LCD cyclic codes over ℜ. Finally, an application of LCD codes in multisecret sharing scheme is given.