bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative analysis of AGR2 based on data mining reveals new insights in breast cancer
Authors: Zhou Xin , Zhang Fangyuan , Liu Yan , Wei Dongxin 
Published: August 2020

Abstract
Background: Belonging to the protein disulfide isomerase (PDI) family, anterior gradient 2 (AGR2) is overexpressed in mucus-secreting cells and endocrine organs such as breast, lung, and ovarian, but its exact function and regulation remain unclear. We aimed to perform integrative analysis of AGR2 in breast cancer.Methods: In our study, a serious of bioinformatic online databases were used to analyze the expression, regulation, prognostic value, and function of AGR2 in breast cancer.Results: The results suggested that AGR2 mRNA was overexpressed in non-basal-like or non-triple-negative breast cancer, but underexpressed in basal-like/ triple-negative breast cancer. AGR2 mRNA expression was correlated with its protein expression. Moreover, the expression of AGR2 was lower in more malignant breast cancer. Furthermore, we also found that DNA methylation, rather than copy number variation, led to AGR2 mRNA overexpression. Prognosis analysis showed no significant correlation between AGR2 level and survival, but in subtype investigation, patients with higher AGR2 level had a significantly better outcome in patients with basal-like / triple-negative breast cancer. Enrichment analysis for co-expression genes of AGR2 revealed that gene sets enriched for chromosome segregation, DNA conformation change, chromosomal region, and GABA receptor activity may play important roles in breast cancer, and that the most significant pathway was “ribosome biogenesis in eukaryotes”, in which negative co-expression genes of AGR2 were enriched.Conclusions: Overexpression of AGR2 was found in less malignant breast cancer, for the first time, our results propose that DNA methylation rather than copy number variation leads to AGR2 overexpression, which can predict favorable prognosis in basal-like/ triple-negative breast cancer, and AGR2 could be a possible regulator of ribosome biogenesis in patients with breast cancer.
Ciphertext-Policy Attribute-based Encryption with Hidden Sensitive Policy for Recruitment in Smart City
Authors: Meng Fei , Cheng Leixiao , Wang Mingqiang 
Published: August 2020

Abstract
Smart city, as a promising technical tendency, greatly facilitates citizens and generates innumerable data, some of which is very private and sensitive. To protect data from unauthorized users, ciphertext-policy attribute-based encryption (CP-ABE) enables data owner to specify an access policy on encrypted data. However, There are two drawbacks in traditional CP-ABE schemes. On the one hand, the access policy is revealed in the ciphertext so that sensitive information contained in the policy is exposed to anyone who obtains the ciphertext. For example, both the plaintext and access policy of an encrypted recruitment may reveal the company's future development plan. On the other hand, the decryption time scales linearly with the complexity of the access, which makes it unsuitable for resource-limited end users. In this paper, we propose a CP-ABE scheme with hidden sensitive policy for recruitment in smart city. Specifically, we introduce a new security model chosen sensitive policy security: two access policies embedded in the ciphertext, one is public and the other is sensitive and fully hidden, only if user's attributes satisfy the public policy, it's possible for him/her to learn about the hidden policy, otherwise he/she cannot get any information (attribute name and its values) of it. When the user satisfies both access policies, he/she can obtain and decrypt the ciphertext. Compared with other CP-ABE schemes, our scheme supports a more expressive access policy, since the access policy of their schemes only work on the ``AND-gate'' structure. In addition, intelligent devices spread all over the smart city, so partial computational overhead of encryption of our scheme can be outsourced to these devices as fog nodes, while most part overhead in the decryption process is outsourced to the cloud. Therefore, our scheme is more applicable to end users with resource-constrained mobile devices. We prove our scheme to be selective secure under the decisional bilinear Diffie-Hellman (DBDH) assumption.
Underweight and low waist circumference prior to percutaneous coronary intervention increase the risk for end-stage renal disease: A Nationwide Population Based-cohort Study
Authors: Bae Eun Hui , Lim Sang Yeob , Oh Tae Ryom , Choi Hong Sang , Kim Chang Seong , Ma Seong Kwon , Kim Bongseong , Han Kyung-Do , Kim Soo Wan 
Published: August 2020

Abstract
Background

The effect of obesity prior to percutaneous coronary intervention (PCI) on the development of end-stage renal disease (ESRD) is not clear.
Methods

Using nationally representative data from the Korean National Health Insurance System, we enrolled 140,164 subjects without renal disease at enrolment who underwent PCI between 2010 and 2015, and were followed-up until 2017. Patients were stratified into five levels based on their baseline body mass index (BMI) and six levels based on their waist circumference (WC; 5-cm increments). BMI and WC were measured at least 2 years prior to PCI. The primary outcome was the development of ESRD.
Results

During a median follow-up of 5.4 years, 2,082 (1.49%) participants developed ESRD. The underweight group (HR 1.331, 95%CI: 0.955–1.856) and low WC (< 80/<75) (HR 1.589, 95%CI: 1.379–1.831) showed the highest ESRD risk and the BMI 25 ~ 30 group showed the lowest ESRD risk (HR 0.604, 95%CI: 0542-0.673) in all participants after adjusting for all covariates. In the subgroup analysis for diabetes mellitus (DM), BMI showed a U-shape relationship with ESRD risk at a baseline of 28.8 for BMI in the none-DM group and a reverse linear relationship in the DM group. However, low WC prior to PCI was risk factor in only DM group.
Conclusions

Underweight and low WC prior to PCI, which showed the increased ESRD risk in patients undergoing PCI, especially in those with DM.
Trial Registration:
Retrospectively registered
Brachial Plexus Anatomy of Miniature Swine Compared to Human
Authors: Hanna Amgad S , Hellenbrand Daniel , Schomberg Dominic , Salamat Shahriar M , Loh Megan , Wheeler Lea , Hanna Barbara , Ozaydin Burak , Shanmuganayagam Dhanansayan 
Published: August 2020

Abstract
Background: Brachial plexus injury (BPI) occurs when the brachial plexus is compressed, stretched, or avulsed. Although rodents are commonly used to study BPI, these models poorly mimic human BPI due to the discrepancy in size. The objective of this study was to compare the brachial plexus between human and Wisconsin Miniature SwineTM (WMSTM), which are approximately the weight of an average human (68–91 kg), to determine if swine would be a suitable model for studying BPI mechanisms and treatments. Methods: To analyze the gross anatomy, WMS brachial plexi were dissected both anteriorly and posteriorly. For histological analysis, sections from various nerves of human and WMS brachial plexi were fixed in 2.5% glutaraldehyde and then myelinated axons were labeled using 2% osmium tetroxide before being counter-stained with Masson’s Trichrome. Results: Gross anatomy revealed that the separation into 3 trunks and 3 cords is significantly less developed in the swine than in human. In swine, it takes the form of upper, middle, and lower systems with ventral and dorsal components. Histological results showed that despite the similarity in body size between the miniature swine model and humans, there was some discrepancy in nerve size and the number of the myelinated axons. The WMS had significantly fewer myelinated axons than humans in median (p = 0.0009), ulnar (p = 0.0001), and musculocutaneous nerves (p = 0.0451). The higher number of myelinated axons in these nerves for humans is expected, because there is a high demand of fine motor function in the human hand, with more motor units. Due to the stronger shoulder girdle muscles in WMS, the WMS suprascapular nerves were larger than in human. Conclusion: Overall, the WMS brachial plexus is similar in size and origin to human making them an excellent model to study BPI. Future studies analyzing the effects of BPI in WMS should be conducted.
CatBoost for Big Data: an Interdisciplinary Review
Authors: Hancock John , Khoshgoftaar Taghi M 
Published: August 2020

Abstract
Gradient Boosted Decision Trees (GBDT's) are a powerful tool for classification and regression tasks in Big Data, Researchers should be familiar with the strengths and weaknesses of current implementations of GBDT's in order to use them effectively and make successful contributions. CatBoost is a member of the family of GBDT machine learning ensemble techniques. Since its debut in late 2018, researchers have ellCcessfully used CatBoost for machine learning studies involving Big Data. We take this opportunity to review recent research on CatBoost as it relates to Big Data, and learn best practices from studies that .55 CatBoost in a positive light, as well as studies where CatBoost does not outshine other techniques, since we can learn lessons from both types of scenarios. Furthermore, as a Decision Tree based algorithm, CatBoost is well-suited to machine learning tasks involving categorical, heterogeneous data. Recent work across multiple disciplines illustrates CatBoost's effectiveness and shortcomings in classification and regression tasks. Another important issue we expose in literature on CatBoost is its sensitivity to hyper-parameters and the importance of hyper-parameter tuning. One contribution we make is to take an interdisciplinary approach to cover studies related to CatBoost in a single work. This provides researchers an in-depth understanding to help clarify proper application of CatBoost in solving problems. To the best of our knowledge, this is the first survey that studies all works related to CatBoost in a single publication.
Long-term oncologic outcomes of laparoscopic low anterior resection of rectal cancer with preservation of the left colic artery
Authors: Luo Yuwen , Li Rongjiang , Wu Deqing , Zeng Jun , Wang Junjiang , Chen Xianzhe , Huang Chengzhi , Li Yong , Yao Xueqing 
Published: August 2020

Abstract
Aim
To analyze the effect of preserving the left colic artery (LCA) on long-term oncologic outcomes during laparoscopic low anterior resection of rectal cancer.
Methods
Clinicopathological and follow-up patients undergoing laparoscopic low anterior resection of rectal cancer in general surgery department of Guangdong Provincial People's Hospital from January 2014 to December 2015 were retrospectively collected. According to the difference surgical methods of inferior mesenteric artery (IMA), 159 cases were divided into the LCA preservation group and 225 cases in the LCA non-preservation group. The 5-year rates of overall survival (OS) and disease-free survival (DFS) were compared between two group.
Results
384 patients were included in final analysis. Anastomotic leakage occurred in 7 patients (4.4%) in the LCA preservation group and in 16 patients (7.1%) in the LCA non-preservation group. The follow-up rate was 91.2% (145/159) during 5–60 months in LCA preservation group, and 89.8% (202/225) during 5–60 months in the LCA non-preservation group. The number of patients who developed death, local recurrence and metastasis were 59 (37.1%), 13 (8.2%) and 60 (37.7%) in the LCA preservation group, and 86 (38.2%), 20 (8.9%) and 92 (40.9%) in the LCA non-preservation group, without significant differences (all P ༞ 0.05). The 5-year OS and DFS rates were 69.0% and 59.3% in the LCA preservation group, and 68.8% and 55.9% in the LCA non-preservation group, without significant differences (all P ༞ 0.05). After stratification by TNM Stage, the difference on 5-year OS rates and DFS rates of I stage, II stage and III stage in two groups were no significant as well (all P ༞ 0.05).
Conclusions
The long-term oncologic outcomes of laparoscopic low anterior resection of rectal cancer with preservation of the LCA are comparable with ligation at origin of IMA.
A transcription factor signature predicts prognosis of patients with adrenocortical carcinoma
Authors: Zhao Jianyu , Liu Bo , Li Xiaoping 
Published: August 2020

Abstract
Background

Adrenocortical carcinoma (ACC) is a rare endocrine cancer that manifests as abdominal masses and excessive steroid hormone levels. Transcription factors (TFs) deregulation is found to be involved in adrenocortical tumorigenesis and cancer progression. This study aimed to construct a TF-based prognostic signature for prediction of survival of ACC patients.
Methods

The gene expression profile for ACC patients were downloaded from TCGA and GEO datasets. The univariate Cox analysis was applied to identify survival-related TFs and the LASSO Cox regression was conducted to construct the TF signature. The multivariate analysis was used to reveal the independent prognostic factors.
Results

We identified a 13-TF prognostic signature comprised of CREB3L3, NR0B1, CENPA, FOXM1, E2F2, MYBL2, HOXC11, ZIC2, ZNF282, DNMT1, TCF3, ELK4, and KLF6. The risk score based on the TF-signature could classify patients into low- and high-risk group. Kaplan-Meier analyses showed that patients in the high-risk group had significantly shorter overall survival compared to the low-risk patients. ROC curves showed that the prognostic signature predicted the overall survival of ACC patients with good sensitivity and specificity. Furthermore, the TF-risk score was an independent prognostic factor.
Conclusions

Taken together, we identified a 13-TF prognostic marker to predict overall survival in ACC patients.
Contrast-enhanced Ultrasound Imaging Can be Used to Evaluate Fetal Cerebral Perfusion: Potential Implications for Fetal Surgery
Authors: Lawrence Kendall M , Coons Barbara E , Sridha Anush , Rossidis Avery C , Davey Marcus G , Flake Alan W , Didier Ryne A 
Published: August 2020

Abstract
Background: Fetal surgery is increasingly performed to correct congenital defects. Currently, fetal brain perfusion cannot be assessed intra-operatively. The purpose of this study was to determine if contrast-enhanced ultrasound (CEUS) could be used to monitor fetal cerebral perfusion during fetal surgery and if parameters correlate with fetal hemodynamics or acid/base status. Methods: Cannulated fetal sheep were insufflated with carbon dioxide gas in an extra-uterine support device and in utero to mimic fetal surgery. Fetal heart rate, mean arterial pressure, and arterial blood gases were serially measured. CEUS examinations of the brain were performed and time-dependent metrics were quantified to evaluate perfusion. The relationships between measured parameters were determined with mixed linear effects models or two-way repeated measures analysis of variance. Results: 6 fetal sheep (113 ± 5 days) insufflated at multiple time-points (n=20 experiments) in an extra-uterine support device demonstrated significant correlations between time-dependent perfusion parameters and fetal pH and carbon dioxide levels. In utero, 4 insufflated fetuses (105 ± 1 days) developed hypercarbic acidosis and had reductions in cerebral perfusion parameters compared to age-matched controls (n=3). There was no significant relationship between cerebral perfusion parameters and fetal hemodynamics. Conclusions: CEUS-derived cerebral perfusion parameters can be measured during simulated fetal surgery and strongly correlate with fetal acid/base status.
Cross-talk between ANGPTL4 gene SNP rs1044250 and weight management is a risk factor of Mets
Authors: Tong Zhoujie , Peng Jie , Lan Hongtao , Sai Wenwen , Li Yulin , Xie Jiaying , Tan Yanming , Zhang Wei , Zhong Ming , Wang Zhihao 
Published: August 2020

Abstract
Background

The prevalence of metabolic syndrome (Mets) is closely related to the increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This case-control study was designed to elucidate the relationship between Angiopoietin-like protein 4 (ANGPTL4) gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the effect of interaction between SNP rs1044250 and weight management on Mets.
Methods

We have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was detected, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle changes, drug treatments and changes in Mets-related indicators.
Results

ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119–2.340]; p = 0.011) and elevated blood pressure (OR 1.323, 95% CI [1.002–1.747]; p = 0.048), the prevalence of Mets (OR 1.875, 95% CI [1.363–2.580]; p < 0.001) is increased. The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [-1, 1]; p = 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased SBP (β = 0.075, p < 0.001) and increased DBP (β = 0.097, p < 0.001), the synergistic effect is negative (S < 1).
Conclusion

ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. Weight management that interacts negatively with ANGPTL4 polymorphism is an essential lifestyle intervention approach for elevated blood pressure.
The relationship between antenatal food insecurity, fetal and postnatal growth: findings from the South African National Income Dynamics Study
Authors: Harper Abigail Joan , Rothberg Alan , Chirwa Esnat , Sambu Winnie , Mall Sumaya 
Published: August 2020

Abstract
Background

Food insecurity during pregnancy has been associated with adverse child health outcomes including low birthweight and stunting. There are few studies that have examined the relationships between food insecurity and child health outcomes in low and middle income countries. This study aims to fill the gap by examining the relationship between food insecurity, low birthweight and stunting in children using a longitudinal sample of South African women and their children.
Methods

The primary exposure is a multidimensional, composite measure of household food insecurity that comprises three dimensions and six indicators. The primary outcome is a dichotomous measure of child LBW (≤ 2500 g) The secondary outcome is childhood stunting (height for age ≤2SD of the median) and severe stunting (height for age ≤3SD of the median) in the first five years of life. We used both unadjusted and adjusted regression models. Source data for the analysis came from the population-based, longitudinal data collected for wave one and three of the National Income Dynamics Study (2008 and 2012).
Results

Birthweight data were available for 1381 children and stunting data were available for 1444 children. The prevalence of LBW in the sample was 13.64%. The prevalence of stunting and severe stunting was 16.46% and 11.87%. The composite measure was not associated with low birthweight but was associated with underweight maternal BMI, a risk factor for low birthweight. Household dietary diversity, food expenditure below the Stats SA poverty line and the composite measure was associated with stunting and severe stunting in bivariate analyses. The measure was associated with severe stunting in the final model.
Conclusions

The finding that household food insecurity is associated with severe stunting for children in the first five years of life highlights the importance of adequate food and nutrition for vulnerable children in South Africa. Future studies can elucidate the relationship between antenatal food insecurity, low birthweight and other child outcomes. Policy interventions that focus on early childhood growth through alleviating food insecurity and addressing other drivers of malnutrition such as improving maternal education and dietary diversity can break the cycle of poor growth outcomes.
Birth Preparedness and Complication Readiness Practice and Associated factors among Women Attending Antenatal care Follow up in Yirgalem General Hospital, Sidama Zone, Southern Ethiopia, 2019
Authors: Gesese Molalegn Mesele , Tirfe Walellign Anmut 
Published: August 2020

Abstract
Background: Birth preparedness and complication readiness is an approach that inspires pregnant women, their families and individuals to successfully design strategy for childbirths and deal with emergencies. In developing countries, world health organization estimates that more than 300 million women suffer from short-term and long-term complications related to pregnancy and child birth. In Ethiopia only 32% women have birth preparedness. The aim of this study is to assess practice and Associated factors of birth preparedness and complication readiness among Women Yirgalem General Hospital, Sidama Zone, Southern Ethiopia, 2019Methods: Facility based cross-sectional study was conducted from September 1st to 30th, 2019. A total of 422 pregnant women were randomly selected and interviewed by using pretested structured questionnaire. Data was entered by Epi-data version 3.1 and the analysis was done by SPSS version 21. Bivariate and multivariable logistic regression was performed to identify factors associated with birth preparedness and complication readiness.Result: From 422 study participants, 356(48.6%) (95% CI: 46.9%, 49.8%) have birth preparedness and complication readiness practice. Age of respondent ≥ 37 years (AOR =4.2, 95% C.I =1.23, 14.24) and between 25 to 30 (AOR=2.35, 95% C.I =1.1, 5.1); level of education College and above(AOR=5.59, 95% C.I 2.8, 11.2)and secondary school (AOR=9.5, 95% C.I 3.99-22); previous history of ANC follow up (AOR=4.33, 95% C.I = 2.46, 7.61) and history of birth at health facility (AOR=3.09, 95% C.I= 1.72, 5.56) where factors associated with birth preparedness and complication readiness practice. Conclusion: Relatively higher birth preparedness and complication readiness practice was observed in this study when compared with previous studies. Health extension workers and health care provider should encouraged women to actively utilize the health services and the governments with other stakeholders should works on antenatal care and institutional delivery by focusing on women those has no formal education.
Reclassification of Chromobacterium Violaceum ATCC 31532 and its Quorum Biosensor Mutant CV026 to Chromobacterium Subtsugae
Authors: Harrison Alisha , Soby Scott 
Published: August 2020

Abstract
The precipitous drop in the cost of genomic sequencing and the concomitant availability of computational methods for comparing genome-level data has made the accurate taxonomic placement of bacteria affordable and relatively rapid. Inaccurate taxonomic placement of bacteria has serious implications in clinical, environmental, and regulatory microbiology, but it can also adversely affect interpretation of research results. The quorum biosensor strain CV026 was derived from an isolate of Chromobacterium that was labeled as C. violaceum ATCC 31532, and is catalogued by the ATCC under that species. Nearly 200 papers have been published that use CV026 as an indicator for quorum sensing activity in many Gram negative bacteria, but the inability of C. violaceum strains to complement the quorum sensing mutation in CV026 has called the taxonomic placement of the parent strain into question. We used molecular phylogeny and a large number of metabolic and phenotypic characters to demonstrate that Chromobacterium strain ATCC 31532 is a member of species Chromobacterium subtsugae.