bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early circulating tumor (ct)DNA dynamics and efficacy of lorlatinib in patients (pts) with advanced ALK-positive non-small cell lung cancer (NSCLC).
Authors: Shaw Alice Tsang , Martini Jean-Francois , Besse Benjamin , Bauer Todd Michael , Lin Chia-Chi , Soo Ross A. , Riely Gregory J. , Ou Sai-Hong Ignatius , Abbattista Antonello , Toffalorio Francesca , Thurm Holger C. , Satouchi Miyako , Camidge D. Ross , Kao Steven Chuan-Hao , Chiari Rita , Gadgeel Shirish M. , Felip Enriqueta , Solomon Benjamin J. 
Published: February 2020

9019 Background: Lorlatinib is a selective, potent, brain-penetrant, 3rd generation (gen) ALK/ROS1 TKI approved for pts with advanced ALK+ NSCLC previously treated with a 2nd gen ALK TKI. We recently showed that ALK mutation tumor genotyping after failure of a 2nd gen ALK TKI may identify pts more likely to respond to lorlatinib.1 To identify other molecular response correlates, we evaluated if early ctDNA dynamics predict clinical outcome on lorlatinib. Methods: In pts enrolled on the ongoing ph 2 study (NCT01970865), plasma samples were prospectively collected for ctDNA analysis at baseline (BL), cycle 3 day 1 (C3D1, or 6 weeks) and end of treatment. Plasma DNA was analyzed using Guardant360. Change in variant allele fraction (dVAF)2 of ALK alterations (fusions and/or mutations) was calculated as (mean VAFC3D1) – (mean VAFBL); dVAF < 0 indicated decreased ctDNA at C3D1. BOR, PFS and OS were evaluated according to dVAF. Results: Of 121 paired BL/C3D1 samples collected from 158 ALK+ pts previously treated with one or more 2nd gen ALK TKIs, 57 (47%) harbored a detectable ALK alteration at BL. At C3D1, mean VAF of ALK fusions and/or mutations was significantly decreased compared to BL (-1.07, p = 0.0014). Mean tumor volume was reduced by 26% in pts with dVAF < 0 (n = 40), but only by 12% in pts with dVAF ≥0 (n = 13) (p = 0.049). Mean dVAF at C3D1 was significantly decreased compared to BL for pts with CR/PR, while there was no significant difference with SD or PD/IND; mean dVAF -1.84, -0.74, and +0.35 in pts with CR/PR, SD, or PD/IND, respectively (p = 0.0011, 0.1444 and 0.3383). Median PFS was 6.6 months (mo) in pts with dVAF < 0 (n = 44) and 2.6 mo in pts with dVAF ≥0 (n = 13) (HR = 2.6, 95% CI: 1.2, 5.8). Median OS was 18.0 mo in pts with dVAF < 0 (n = 34) and 8.6 mo in pts with dVAF ≥0 (n = 13) (HR 2.0, 95% CI, HR 0.9–4.6). Conclusions: Early ctDNA dynamics may predict lorlatinib efficacy in ALK+ NSCLC, with decreased ctDNA at 6 wks associated with better response and longer PFS. Further studies are needed to validate these findings and to determine whether early intervention based on dynamic ctDNA monitoring may improve outcome. References: 1. Shaw, et al. J Clin Oncol. 2019. 2. Raja, et al. Clin Cancer Res. 2018. Clinical trial information: NCT01970865.
A phase II trial of nintedanib in recurrent malignant pleural mesothelioma (MPM).
Authors: Wozniak Antoinette J. , Schneider Bryan J. , Kalemkerian Gregory Peter , Daly Robert Michael , Chen Wei , Ventimiglia Jaclyn , Nagasaka Misako , Zauderer Marjorie Glass 
Published: February 2020

e20061 Background: Malignant pleural mesothelioma (MPM) is a disease that is resistant to chemotherapy and there remains an unmet need for better therapeutic options. Nintedanib (BIBF 1120) is an oral multikinase inhibitor impacting VEGFR, FGFR, PDGFR, and other kinase activity such as TGFß signaling pathways. VEGF, FGF, and TGFβ are commonly expressed in MPM. We conducted a phase II trial in patients with recurrent MPM after platinum-based chemotherapy. Methods: Patients (pts) with MPM previously treated with platinum-based chemotherapy, performance status (PS) 0-1, adequate organ function, and no contraindications to anti-angiogenic therapy were eligible for treatment. Nintedanib 200 mg twice per day was administered until disease progression or unacceptable toxicity. The primary endpoint was the 4-month progression-free survival (PFS). A two-stage design was used and > 4 pts had to have a PFS of ≥4 months to proceed to the second stage. Results: Twenty pts. were enrolled. The median age was 70 yrs. (32-81), 90% were male, and 80% were PS = 1. The histology was 70% epithelioidal, 5% sarcomatoid, 10% biphasic, and 15% unknown. 15% had prior bevacizumab. The median follow-up is 16.4 mo. A median of 2 treatment cycles (range 1-18) were delivered. There were no responses but 40% had stable disease. The median PFS was 1.8 mo. (95% CI: 1.68, 3.55) and the PFS rate at 4 mo. was 13%. The median OS was 4.2 mo. (95% CI: 2.53, 8.74) and the OS rate at 4 mo. was 55%. Toxicities were usually grade 1-2 and included diarrhea, fatigue, edema, transaminase elevation, anorexia, nausea, vomiting and dyspnea. Conclusions: The activity of nintedanib in previously treated MPM pts. was modest. The trial did not meet the primary PFS endpoint. However, there was a small subset of pts. that had prolonged stable disease for > 4 months thus potentially deriving some clinical benefit from treatment. Supported by Boehringer Ingelheim. Clinical trial information: NCT02568449.
Psychological components of professional image of inspectors of the road patrol service of the State road safety Inspectorate and directions for its improvement
Authors: Borisova Svetlana 
Published: February 2020

The article deals with psychological components of the phenomenon of the professional image of the inspectors of the Road Patrol Service of the State Road Safety Inspectorate are the subject of the study.
The purposes of the scientific article are to present psychological characteristics of leading components of the professional image of the inspectors of the Road Patrol Service of the State Road Safety Inspectorate and to determine the trends of its improvement.
It’s established that the most significant elements of the discussed professional image are appearance, knowledge of normative legal acts, the culture of dialogue, competent speech and the ability to handle stress and require urgent attention and development – a normative legal acts and speech skills.
A synthesis of the literature and an empirical study carried out using methods of a written survey, observation, ranking, and analysis of situations has allowed not only to reveal the psychological meaning of each component image, but also to identify the likely directions of its improvement. A special place among these directions is given to improving the quality of legal and psychological training, and training in practical linguistics in the field of business communication with traffic participants.
The scientific novelty of research consists in the reflection of the modern view on the problem of professional image of the employee through the eyes of the subjects of its formation and in the formulation of specific proposals based on the experience of the respondents and sought after in the course of further modernization of the image of the inspectors of the Road Patrol Service of the State Road Safety Inspectorate.
Prevention and treatment of high altitude pulmonary edema (HAPE)
Authors: Mazur Karol , Machaj Dominik , Jastrzębska Sandra , Płaczek Alicja , Mazur Dominika 
Published: February 2020

High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema, that develops within the first 2–5 days in rapidly ascending individuals at altitudes above 2,500-3,000 m. The clinical features are cyanosis, tachypnoea,tachycardia and elevated body temperature generally not exceeding 38.5 °C. It is often severe and potentially fatal manifestation of acute mountain sickness (AMS).The aim of this study was to assess the methods of prevention and treatment of high altitude pulmonary edema (HAPE). Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years .The second step was to carry out an overview of the found publications.Gradual ascent and staged ascent are the most effective methods of prevention of HAPE Pharmacologic prophylaxis with nifedipine should only be considered for individuals with a history of HAPE. Before initiating treatment of HAPE differential diagnosis should be done. Descent shoud be initaited and oxygen therapy shoud be started when HAPE is suspected or diagnosed. If these methods are unavailable, nifedipine or Gamow bag can be used.
Prevention and treatment of high altitude cerebral edema (HACE)
Authors: Mazur Karol , Machaj Dominik , Jastrzębska Sandra , Płaczek Alicja , Mazur Dominika 
Published: February 2020

High altitude cerebral edema (HACE) is often a severe and potentially fatal manifestation of acute mountain sickness (AMS). It usually develops within the first 2 in individuals rapidly ascending at altitudes above 4000 m. The main cause of HACE is hypoxia, because of reduced oxygen level at high altitude.The aim of this study was to to assess the methods of prevention and treatment of high altitude cerebral edema (HACE). Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years. The second step was to carry out an overview of the found publications.Methods of prevention of acute mountain sickness are highly effective in high altitude cerebral edema prevention. Many studies estabilished the role of gradual ascent and staged ascent as well as administration of acetazolamide and dexamethasone in AMS prevention, and therefore in HACE prevention. Methods of treatments of acute mountain sickness are highly effective in high altitude cerebral edema treatment. Several researches proved the role of descent, administration of acetazolamide and dexamethasone, oxygen therapy as well as use of portable hyperbaric chamber in AMS treatment, and therefore in HACE treatment. However HACE treatment requires greater descent and larger doses of dexamethasone. Also duration of recovery is longer.
Zapisy na marginesach stronic halickich starodruków cerkiewnych z XVII wieku
Authors: Stasiuk Andrij 
Published: February 2020

Margin Notes of Galician Church Old Printed Books of the 17th Centuries
The article is devoted to the collection of church old printed books of the 17th centuries, which are stored in the National Reserve “Davniy Halych” or are investigated by scientists of this institution during 1994-2018 years. The main objects of the studios were more than 50 liturgical books, which came from parishes of the Galician orthodox / greek-catholic church organization. Particular attention is paid to the problem of cataloging of printed memos, as well as their study in the context of the source-study perspective. The important element of the study consists of the margin notes, first of all represented by the offering texts that often inform contemporaries about the already nonexisting churches. However, unusual notes, such as a piece of a carol, chronicles or correction of liturgical texts through confessional motives occur on book pages.
Próby uporządkowania archiwów miejskich na prowincji galicyjskiej w 2 poł. XIX w.
Authors: Więch Arkadiusz S. 
Published: February 2020

Attempts at Ordering Municipal Archives of Galician Smaller Towns and Settlements in the Second Half of the 19th Century: An Introduction to the Problem
The second half of the 19th century saw an increased interest in documents that were stored in various public offices, institutions, and archives throughout Galicia (Kingdom of Galicia and Lodomeria). However the condition of the documents themselves and of their storage were far from ideal. When modern archives were established in Krakow and Lvov, a regulation by National Department (the executive organ of the local parliament Landtag) of July 22, 1887 started the process of registering, ordering, gathering, and preserving of the documents. These efforts were vastly supported by an association of Galician conservators Grono Konserwatorów Galicyjskich.
Nieznana praca o historii stosunków polsko-ukraińskich w Galicji autorstwa Mariana Tyrowicza w zbiorach Archiwum Nauki PAN i PAU w Krakowie
Authors: Świątek Adam 
Published: February 2020

An Unknown Scholarly Text about Polish-Ukrainian Relations in Galicia by Marina Tyrowicz in the Archives of PAN and PAU in Krakow
The paper aims at acquainting the reader with an unknown typescript by Marian Tyrowicz (1901-89), a Lvov-born researcher of Galicia (Kingdom of Galicia and Lodomeria) who was a professor of the Higher School of Pedagogy (today’s Pedagogical University) in Krakow after WWII. The text entitled A Brief Outline of the Ukrainian-Polish Relations in Galicia and Reborn Poland (1772-1939) was created under the German occupation of Lvov in 1943 and is kept in the Scientific Archive of PAN and PAU in Krakow now. Since the unclear copyright status currently prevents its publication, the author of the paper has decided to present its contents and make the most significant findings of Tyrowicz available to scholars. Based on relevant Polish and Ukrainian antebellum literature Tyrowicz arrived at a synthetic picture of relations between Poles and Ruthenians (Ukrainians) on the territory of Eastern Galicia with reference to the political situation, foreign relations, and socio-cultural processes.
Z dziejów Polaków w radzieckim Lwowie – przypadek Marii Tereszczakówny
Authors: Olechowski Piotr 
Published: February 2020

From the Lives of Poles in Soviet Lvov: The Case of Maria Tereszczak
The paper discusses repressions of the Soviet security apparatus against a Lvov social activist Maria Tereszczak beginning with her arrest by counterintelligence bureau SMERSH in 1945, through a court trial, deportation, time in a labor camp, and her return to Lvov. It also depicts a seemingly hopeless struggle of the Pole to regain her good name. After ten years her sentence was annulled and she was rehabilitated. This development was a rare event at the time of the Brezhnev rule in the USSR.
"Opisy zabytków w kościołach i na cmentarzach w dekanatach: zwinogródzkim, radomyślskim i białocerkiewskim" ze zbiorów Aleksandra Czołowskiego w Bibliotece Narodowej
Authors: Biedrzycka Agnieszka 
Published: February 2020

“A Description of Antique Objects in Churches and Cemetries in the Deaneries of Zwinogród, Radomyśl, and Biała Cerkiew” in the Collection of Alexander Czołowski in the National Library
The edition is a presentation of antique objects in churches, chapels and cemeteries in the in the deaneries of Zwinogród, Radomyśl, and Biała Cerkiew of the former Roman-Catholic diocese of Żytomierz (today’s diocese of Kiev-Zhytomir in Ukraine) which was written by two anonymous authors between 1890 and 1894. The manuscript of these descriptions, unanalyzed by scholars as yet, found its way to the collection of a Lvov historicist and archivist Alexander Czołowski (1865-1944). A short time before his death the collection was evacuated by him from Lvov to Tyniec and subsequently sold to the National Library in Warsaw (sign 5705 II) by his daughter in 1947. The manuscript contains fairly succinct descriptions of sacral objects and cemeteries (the majority of which are nonexistent or ruined now) in Zwinogródka, Talne, Wodzianiki, Tołsta, Łysianka, Koszowata, Taraszcza, Brusiłów, Biała Cerkiew, and Didowszczyzna as well as close to 300 transcripts of inscriptions from tombstones, epitaphs, and commemorative plaques from these places that belong to the Chojecki family, Olga Naryszkin née Potocka, general-major of artillery Piotr Olszewski, author Robert Stanisławski, professor of medicine Bronisław Chojnowski, physician, amateur geographer and sculptor Adolf Rykman, and others.
Vegetable-based Oil as UTTO Fluid for Agricultural Tractors Application
Authors: Pochi Daniele , Fanigliulo Roberto , Bisaglia Carlo , Cutini Maurizio , Grilli Renato , Betto Monica , Fornaciari Laura 
Published: February 2020

HighlightsLubricants are commonly used in agricultural activities involving machines.To reduce lubricants impact on the environment, a process has been started for replacing them with products obtained from vegetable oils.Tests have been carried out to explore the possibility of introducing vegetable-based UTTO in tractors.Results encourage to deepen the behavior of vegetable-based oils and develop specific test bench and methods.Abstract. To reduce the impact of mineral and synthesis lubricants on the environment, a process has been started for replacing them with lubricants and hydraulic fluids obtained from high-oleic vegetable oils, with good tribological properties, high biodegradability, and low toxicity. Test have been carried out at Research Center for Engineering and Agro-Food Processing of Monterotondo, Rome, Italy, with the aim of comparing the performances provided by a standard agricultural tractor supplied with conventional Universal Tractor Transmission Oil (UTTO) fluid and with a vegetable-based oil in their transmission-hydraulic system group. The research aimed at assessing differences, if any, in tractor’s performances attributable to the fluids in comparison. For a better comparison, the tests were carried out under controlled conditions, connecting the tractor, at first to a dynamometric brake used in engine and transmission tests, then to a test rig for hydraulic lifts. The results, although non generalizable, were encouraging, indicating that the tractor’s performances with the two fluids, after 30 h work cycles, were similar both for transmission and hydraulic lift. On the other hand, the reduction observed in the viscosity of the biofluid requires the deepening of the aspects related to its durability. The results also allowed to focus some basic aspects of the evaluation of biofluids and to identify some methodological approaches mainly based on the comparation of fluids performance during repeatable work cycles and on the assessment of how their physical properties evolve overtime. Keywords: Biolubricant, Engine performance, High-oleic sunflower oil, Hydraulic lift, Lifting force, Power transmission.
Analysis of Vibration Harvesting Properties and Fracturing Structures of Soapberry (Sapindus Mukorossi)
Authors: Cui Wenzhe , Xu Daochun , Wang Hu , Yuan Xiaolong 
Published: February 2020

HighlightsAnalyzing the fruit removal force and harvesting time of Sapindus fills a gap of Sapindus research.A dual excitation vibration method for harvesting Sapindus and the best harvesting parameters were obtained.The microstructure of the different fracturing locations was analyzed for the first time. Abstract.To address the issue of labor intensity in the harvest of Sapindus fruit, it is necessary to understand the harvesting properties of Sapindus mukorossi. In this study, a fruit removal force (FRF) test platform was used to analyze the relationship between the FRF and maturation time. An eccentric vibration harvesting test was conducted to obtain the frequency, acceleration, and other parameters of the Sapindus tree. According to the different falling locations of fruit, the fracturing locations were observed by a scanning electron microscope (SEM). The results revealed that the optimal time (9 to 12 November) to harvest is in the middle of the harvest period. Additionally, the shear force from 1.0N to 5.2 N was less than the tensile force from 2.7 to 10.2 N. Therefore, back and forth swinging is the major fracturing form of the fruit. Moreover, dual excitation is preferable to single-point excitation, and the acceleration root mean square (RMS) of the dual excitation was two to three times the acceleration RMS of single point excitation. The harvesting efficiency of dual excitation was 92.3% at 20 Hz. Additionally, there existed four fracturing locations for harvested fruit, as the frequency increased. Furthermore, the fracturing in the ear and stem was the most important form of fracturing, and microscopic observations revealed that it had a thinner and tidier cell wall and cell cavity. Keywords: Sapindus, Fruit removal force, Vibration, Microstructure.
Effect of Sodium Chloride Concentration on Removal of Chemical Oxygen Demand and Ammonia from Turkey Processing Wastewater in Sand Bioreactors
Authors: Conroy Kristen M , Chen Feng , Tuovinen Olli H. , Mancl Karen M. 
Published: February 2020

HighlightsSand bioreactors can effectively treat organic matter at salt levels at least up to 13 g L-1 NaCl.Acclimation of the systems for ammonia removal can take &gt;4 weeks.Clogging and reduction in treatment efficacy can be alleviated through resting of sand bioreactors. Abstract. The treatment of high salt (&gt;1%) wastewater is an issue in several food industries, including meat curing, vegetable pickling, and fish processing. Novel solutions involving biological treatment of saline wastewaters are increasingly important as companies strive to minimize waste production. Sand bioreactors are a secondary treatment option that do not produce secondary sludge. The purpose of this study was to assess the feasibility of treating high salt content poultry processing wastewater with sand bioreactors. Twelve laboratory-scale sand bioreactors consisted of 14.5-cm diameter columns with three layers composed of 15 cm of gravel, 15 cm of coarse sand, and 46 cm of fine sand. The columns were dose fed at 4 cm day-1 turkey processing wastewater with 0, 6, and 13 g L-1 NaCl. Removal of chemical oxygen demand (COD) and ammonia were monitored for over an 11-month period. Each bioreactor successfully removed &gt;90% COD and ammonia during steady state after 4 to 5 week of acclimatization. Clogging caused a decrease in treatment in three sand bioreactors after 6 to 7 months, but was alleviated with rest periods. Keywords: Ammonia removal, Clogging, High salt wastewater, Organic matter removal, Sand bioreactor, Turkey processing wastewater.
'Like a Dance': Working creatively with healthcare practitioners to explore mobility and osteoporosis
Authors: Smith Margaret A. Coulter , Schrag Anthony , Kelly Fiona , Pearson Claire 
Published: February 2020

Abstract
Collaborations between health sciences and creative arts can generate insights into complex health phenomena. This article describes a creative workshop derived from an action research project that aimed to raise awareness of fracture risk in health practitioners supporting people with osteoporosis. The creative workshop aimed to provide opportunities for practitioners within the action research community to create new knowledge and share their practice insights. The article considers the notion of creative arts as a physical, embodied process that can facilitate learning by enabling tacit knowledge to be made explicit. Rather than applying an instrumental approach to arts within healthcare, the workshop became a mechanism for the convergence of ideas, disciplines and support structures and provided a learning environment where old beliefs could be challenged, practice insights shared and new knowledge constructed. We discuss the workshop development and outputs and suggest the utility of this approach for collaborative learning.