bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of mandatory glaucoma screening in all patients from outreach cataract camps referred to a base hospital for cataract surgery
Authors: Tomar Vijay P. S. , Sharma Sandeep , Bhardwaj Rahul , Bamel Arjun , Bobade Amrapali , Bhadauria Madhu 
Published: September 2020

Background: Glaucoma is the first cause of irreversible blindness and second leading cause of visual loss in the world. The purpose of this study was to conduct mandatory glaucoma screening and to find out the prevalence of glaucoma, in all patients referred for cataract surgery to a base hospital. Methods: A retrospective analysis was conducted of all patients referred from rural screening camps to base hospital for cataract surgery. Medical records of 5024 consecutive patients referred to base hospital from the month of January to June 2019 were reviewed. All these 5024 patients underwent comprehensive ophthalmic and systemic examination. Those patients in which glaucoma was suspected, were referred to glaucoma clinic for further evaluation.Results: Total 5024 patient’s records were analysed retrospectively. The mean age of the participants was 57.2±8.149 ranged from 40-95 years and average age of patients having cataract with glaucoma was 61.3±9.423. Total patients of glaucoma with cataract were 188 (3.7%). The prevalence of primary open angle glaucoma (POAG) and Primary angle closure glaucoma (PACG) was 1.69% and 1.17% respectively while secondary glaucoma was found in 0.88% of the patients. The prevalence of ocular hypertension, PAC and PACS was 0.33%, 0.29% and 0.83% respectively.Conclusion: The prevalence of glaucoma in this study was 3.7% of those planned for cataract surgery. Therefore, mandatory glaucoma screening in all patients from outreach cataract camps would result in detection of a large number of those with undiagnosed glaucoma.
Quality of life in chronic kidney disease: a community perspective using world health organization quality of life: BREF questionnaire
Authors: Jacob Sabitha R. , Kannan Suthanthira , Raveendran Rini , Wilson Tom 
Published: September 2020

Background: The quality of life is an important assessment tool in improving the quality of care among chronic kidney diseases (CKD) especially in a palliative care setup. This study attempted to assess the quality of life of chronic kidney disease patients.Methods: This community based cross sectional study was conducted among 140 patients who were registered at palliative clinics in Malappuram District, Kerala using a standard tool for quality of life (QOL) in Malayalam version. Domain scores were analysed across clinic epidemiological factors.Results: Mean age of the study population was 53.99 (14.36%). Majority 73 (52.1%) were educated up to upper primary. The median duration of CKD was 4 years and ranged from 3 months to 22 years. 55.3% were undergoing dialysis 16.3% had renal transplantation. Hypertension was reported by 65% and diabetes by 50.7%. The highest score was obtained in the environmental and lowest in the psychological domain. Age below 40 years, male gender and provision of an income was associated with better QOL scores and perception scores. QOL was significantly higher in all domains among those who had undergone renal transplantation compared to those on hemodialysis. Conclusions: The status of renal transplantation and younger age group positively affected the good quality of life. Considering the cost of renal transplantation and post-transplant survival peritoneal dialysis could be promoted in low resource settings. Secondary prevention of hypertension and diabetes should be addressed at programme level to delay nephropathy.
Dynamics of sociocultural and linguistic identity in the process of socialisation in a multicultural society
Authors: Belinskaya Elena , Martsinkovskaya Tatiana , Orestova Vasilisa , Kiseleva Ekaterina , Kriger Evgenia 
Published: September 2020

The relevance of the problem of socialisation in multicultural space is extremely high. Its significance is connected with the processes of globalisation and increasing migration. In this situation, the sociocultural and, especially, linguistic identity can be analysed as a bonding and bridging social capital that helps or complicates socialisation, depending on the specifics of the social situation. These assumptions were checked in the empirical research of the sociocultural and linguistic identity of the three groups of ethnic Germans: living in Russia, in the CIS and those who moved to Germany. The obtained data showed the bilingualism of the majority of respondents. At the same time, respondents from Russia and Germany consider both Russian and German languages as native, while respondents from the CIS no longer regard German as their mother language. For them, ethnic, not linguistic, identity is the most essential for socialisation in a multicultural society. For Germans living in Russia, on the contrary, both languages help in communication and in professional activity. For the Germans, who now live in Germany, the Russian language helps in understanding their sociocultural specifics. The future is associated with the German language. Our respondents answer that the main group of socialisation for them is the family. This was especially marked in the answers of respondents living in Russia and Germany. So, we can state that in a complex multicultural environment, the family for them is not only a group for socialisation, but also an object of identity, partly playing the role of psychological defence and support in a changing world. The obtained results also showed a tendency towards individualisation. For the respondents from Russia and Germany, the main identity groups, besides family, are professional groups and groups with common interests. Thus, it can be concluded that linguistic identity plays the role of both bonding and bridging social capital. In positive socialisation, sociocultural identity plays the role of a bridging rather than a connecting capital. Mixed linguistic identity is predominantly a positive moment, increasing socialisation in a multicultural environment.

Keywords: Socialisation, transitivity, identity, multicultural world.
People's self-fulfillment in modern digital society
Authors: Vitulyova Yelizaveta 
Published: September 2020

In modern society there is an acute problem of self-realization of people who possess remarkable intellectual potential, since their creative abilities, generally remain unsatisfied. The issue can be solved on the base of Internet of Things (IoT) concept, by making different tools for indoor creativity (such as 3D-printers which provide building useful products, knitting machines with embedded artificial intelligence, etc.). It is proved that solving the problem of self-fulfillment has crucial meaning both for development of science and art, as right in this case social sustainable demand for development of science and art arises. In the absence of a distinct social demand development of science and art, these areas of human activity can develop only with the help of state support, which significantly degrade their efficiency (also in purely economic terms).

Key words: the fourth technological revolution, digital society, citizen’s self-fulfillment, artificial intelligence, creativity, neural networks, bureaucracy
Effect of using guided inquiry teaching method in improving grade eight students’ concept of photosynthesis, primary school: Ethiopia
Authors: Dagnew Asrat , Mekonnen Desta 
Published: September 2020

The main objective of this study was to investigate the effect of using guided inquiry teaching method in improving grade eight students’ conceptual understanding of photosynthesis. The study employed Quasi-experimental research method. The data collection instruments were multiple choice tests, observation, as well as informal assessment. The pre-test and post-test were administered before and after treatment respectively. The informal assessment also administered before and after intervention. Besides, the observation was conducted from the first day up to the last day of the intervention. The pre-test and post-test data were analyzed using descriptive statistics and t-tests quantitatively while; data collected through informal assessment and observation were presented using narration. The finding of pre-test revealed that there was no significant difference between the mean score of the two groups. The post-test result revealed that experimental group students significantly improved their conceptual understanding of the topic photosynthesis compared to the control group students. The study concluded that guided inquiry teaching method is more effective than the lecture method in improving students’ conceptual understanding of photosynthesis. Based on the finding of this study, it was recommended that governments should encourage biology teachers to apply guided inquiry teaching method by providing appropriate instructional material.
Keywords: Conceptual understanding Guided inquiry, photosynthesis,
Media and educational technology in Nigeria: Managing the broadcast programmes of Radio Nigeria Globe FM towards girl child education
Authors: Bello Hashim Sabo , Idris Sa’adatu Umar , Bappayo Abubakar 
Published: September 2020

This study was carried out in Shall and Yalwa village areas of Tafawa Balewa and Dass local government areas, respectively, in Bauchi state (Nigeria) with a strong view of determining the efficacy of media in education towards managing girl child issues in Nigeria. An intensive oral interview was employed in data collection from staff of Radio Nigeria Globe FM, as well as the students and staff of schools and the parents from both Shall and Yalwa villages. The study employed a survey design and utilized a documentary approach to obtain data. Descriptive statistics (means, frequency and percentages) and χ2were used in analysing the socio-economic characteristics of the stakeholders in girl child education. The results revealed that 91.2% of the responses hold the opinion that the strategies used by the Radio Nigeria GlobeFM to intervene in girl child education proffered unique and far-reaching benefits in educating the girl child to discover herself and associate with the right group of people, marry the right kind of men, make the right contributions and help men develop sustainable environment. The results also revealed that 61.8% of the responses hold the belief that Radio Nigeria GlobeFM programmes on the Nigerian girl child are much effective, educative and relevance. The study suggested that the adoption of educational technology strategies is a way forward to managing girl child education, which is a progressive approach in Nigeria, there by setting up booster stations and organise village rallies, discussion programmes with women as moderators to serve as role models for young girls, radio links programme to initiates talks with parents and other stakeholders, initiate kiddies programme fashioned after the likes of the world of children and finally strategies for career guidance.

Keywords: Broadcast programme, educational technology, girl child, management, media.
Framework conceptual para el diseño colaborativo de Sistemas de Información en Salud
Authors: Castrillón-Cobo Helder Yesid , Erazo-Paruma Leydi Rocío , Gallego-Gómez Erika Liliana 
Published: September 2020

El diseño de sistemas de información ajustado a las necesidades del sector salud requiere una atención especial, debido a la complejidad de la información, la compatibilidad y el soporte de los sistemas requerido para este sector. A pesar de existir iniciativas nacionales para la estandarización de la información que comparten las entidades del sector salud, existen factores como el déficit financiero del sector y los malos manejos de los recursos que impactan de forma negativa en esta estandarización y también en la prestación de los servicios de salud, especialmente, los relacionados con los derechos sexuales y reproductivos.
En este artículo se propone un framework conceptual para el diseño colaborativo de sistemas de información en salud, inicialmente priorizado para el dominio de salud sexual y reproductiva, lo cual permitirá contar con un marco de trabajo que contribuya en la captura, el almacenamiento, el tratamiento y la consulta de la información de salud de los colombianos de una forma estandarizada, actualizada y segura. El framework se compone de una ontología de dominio, una guía de implementación y otros componentes que permiten la escalabilidad de este, lo cual evidencia la importancia de este tipo de soluciones para este sector, y promueve el diseño de sistemas de información en salud bajo el concepto de trabajo colaborativo entre las organizaciones interesadas. Los resultados obtenidos muestran que la estandarización de la información y el trabajo colaborativo permite diseñar sistemas más eficientes y al mismo tiempo compatibles e interoperables, lo cual reduce los trámites administrativos y la pérdida de datos importantes en la atención médica.
MENINGKATKAN HASIL BELAJAR GERAK DASAR MELEMPAR DENGAN MEDIA AUDIO VISUAL PADA SISWA KELAS III SDN 03 JELAMBAR BARU JAKARTA BARAT
Authors: YUSMAWATI YUSMAWATI , Rihatno Taufik , Rismawanti Rismawanti 
Published: September 2020

Penelitian ini bertujuan untuk meningkatkan hasil belajar melempar dengan media audio visual. Subjek penelitian adalah siswa kelas III A SDN 03 Jelambar Baru Jakarta Barat yang terdiri dari 30 siswa. Metode yang digunakan yaitu metode Penelitian Action Research, yakni dengan memberi tindakan khusus kepada subjek untuk meningkatkan hasil belajar gerak dasar melempar melalui media audio visual. Hasil penelitian, yaitu melalui metode penelitian tindakan dengan menggunkan alat bantu belajar audio visual dapat meingkatkan hasil belajar gerak dasar melempar pada siswa kelas III SDN 03 Jelambar Baru Jakarta Barat, hal ini terlihat dari tingkat kelulusan subjek dari tes awal berjumlah 10 siswa atau presentase 33,3% sedangkan 20 siswa atau presentase 66,7% belum mencapai nilai kelulusan. Setelah melakukan tindakan siklus kedua hasil kelulusan meningkat signifikan semua siswa sudah dapat melakukan tahapan gerak dasar melempar dengan benar, kelulusan pada tes terakir berjumlah 30 siswa atau presentase 100%.
METODE PEMANASAN MODIFIKASI MEMPERPENDEK WAKTU TEMPUH RENANG GAYA BEBAS 50 METER
Authors: Rachma Zulfata  , Bambang Purwanto  , Harlina  
Published: September 2020

Salah satu faktor yang mempengaruhi waktu tempuh renang yaitu metode pemanasan yang digunakan. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan prosedur pemanasan standar dengan modifikasi pada renang gaya bebas 50 meter terhadap waktu tempuh renang. Jenis penelitian yang digunakan yaitu eksperimen lapangan dengan rancangan pretest – posttest same sample design. Sampel pada penelitian ini berjumlah 26 altet renang Sidoarjo Aquatic Club (SAC) menggunakan metode purposive sampling dan membagi kelompok dengan random sampling. Waktu tempuh yaitu melalui tes renang gaya bebas 50 meter. Metode standar yaitu (swim, kick, drill, swim), sedangkan metode modifikasi yaitu (swim, drill, kick, swim). Hasil pada penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara sebelum dan sesudah pemberian metode pemanasan modifikasi (p<0,05). Kesimpulan pada penelitian ini adalah metode pemanasan modifikasi memperpendek waktu tempuh renang gaya bebas 50 meter.
Disparities in Urban and Rural Dwelling Adolescents' Educational Needs for Obesity Prevention in Nigeria
Authors: Zibima Soupriye B. , Wasini Kenneth B. , Oniso Juliet I. 
Published: September 2020

Background and Objectives:
Obesity has increased in recent times and has attained an epidemic status worldwide, incuding in Nigeria. Prevalence of obesity rises during adolescence and prevention is advantageous. However, it is unknown whether rural and urban dwelling adolescents in Bayelsa State in the Niger Delta region of Nigeria have the requisite knowledge needed to prevent obesity. The objective of this study was to determine the educational needs of urban and rural dwelling adolescents for obesity prevention.

Methods:
The study was a school-based cross-sectional survey, and employed multistage sampling technique to select six secondary schools across the three senatorial districts of the state. An adapted and validated sub-scaled obesity knowledge questionnaire was used to obtain data from 2,304 secondary school students. Statistical Package for Social Sciences (SPSS) version 23.0 was used for data analysis.

Results:
The total number of urban male students and rural male students was 576 (25.00%). The total number of urban female students and rural female students was also 576 (25.00%). The sample mean age of participants was 16.77 (SD±79), and those aged 16 years 1,043 (45.27%) were the largest portion of the sample. Generally, 756 (32.81%) of the participants had good knowledge of obesity. Specifically, subscale analysis showed that 622 (27.00%) participants had good knowledge of risk factors for obesity; 519 (22.53%) had good knowledge of complications of obesity; 659 (28.60%) had good knowledge of prevention for obesity; and 653 (28.34%) had good knowledge of meaning/assessment of obesity. Difference in mean score between urban (M= 3.80, SD = 0.44) and rural residents (M = 3.72, SD = 0.43; t = 4.63, p = 0.00, 2-tailed) was significant.

Conclusion and Implications for Translation:
Adolescents' knowledge regarding obesity is generally inadequate, especially in rural areas. Adolescents need education to acquire fundamental knowledge of the meaning/assessment, risk factors, prevention, and complications of obesity for prevention.
Adaptive Immune Responses Mediated Age-related Plasmodium yoelii 17XL and 17XNL Infections in 4 and 8-week-old BALB/c Mice
Authors: Wang Qiu-bo , Du Yun-ting , Liu Fei , Sun Xiao-dan , Sun Xun , Chen Guang , Pang Wei , Cao Yaming 
Published: September 2020

Abstract
Backgroud: As the quest to eradicate malaria continues, it is important to clarify the opposite clinical outcomes between childhood and adulthood. The relationship between adaptive immune response and age-related malaria infection remains unknown. Methods: 4 and 8-week-old mice were used to mimic childhood and adulthood, respectively. Parasitemia and the survival rate were monitored. The proportion and function of Th1 and Th2 cells were detected by FACS. The levels of IFN-γ, IL-4, total IgG, IgG1, IgG2a and Plasmodium yoelii MSP-1-specific IgG were measured by ELISA. Results: Our results found that childhood mice were more susceptible to P. yoelii 17XNL infection, with lower survival rate and higher parasitemia. The adult group showed greater resistance to P. yoelii 17XL infection, with lower parasitemia. Compared with 4-week-old mice, the percentage of CD4+T-bet+IFN-γ+ Th1 cells as well as IFN-γ production were significantly increased on day 5 p.i. in the 8-week-old mice after P. yoelii 17XNL infection. The percentage of CD4+GATA3+IL-4+ Th2 cells and CD4+CXCR5+ Tfh cells, and IL-4 production in the 8-week-old mice significantly increased on day 5 and day 10 after P. yoelii 17XNL infection. Notably, the levels of total IgG, IgG1, IgG2a and P. yoelii MSP-1-specific IgG were also significantly increased in the 8-week-old mice. PD-1, a marker of exhaustion, was up-regulated on CD4+ or activated CD4+ T cells in the 8-week-old mice as compared to the 4-week-old group. Conclusions: Thus, we consider that enhanced cellular and humoral adaptive immunity might contribute to rapid clearance of malaria among adults, likely in a PD-1-dependent manner due to induction of CD4+ T cells exhaustion in P. yoelii 17XNL infected 8-week-old mice.
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma
Authors: Li Jinyou , Li Qiang , Su Zhenyu , Sun Qi , Zhao Yong , Feng Tienan , Jiang Jiayuan , Ma Haitao , Zhang Feng 
Published: September 2020

Abstract
Background: Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD. Methods: In this study, expression analysis of 1045 lipid metabolism-related genes was performed between LUAD tumors and normal tissues derived from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) cohort. The interaction network of differentially expressed genes (DEGs) was constructed to identify the hub genes. The association between hub genes and overall survival (OS) was evaluated and formed a model to predict the prognosis of LUAD using a nomogram. The model was validated by another cohort, GSE13213. Results: A total of 217 lipid metabolism-related DEGs were detected in LUAD. Genes were significantly enriched in glycerophospholipid metabolism, fatty acid metabolic process, and eicosanoid signaling. Through network analysis and cytoHubba, 6 hub genes were identified, including INS, LPL, HPGDS, DGAT1, UGT1A6, and CYP2C9. High expression of CYP2C9, UGT1A6, and INS, and low expressions of DGAT1, HPGDS, and LPL, were associated with worse overall survival for 1925 LUAD patients. The model showed that the high-risk score group had a worse OS, and the validated cohort showed the same result.Conclusions: In this study, a signature of 6 lipid metabolism genes was constructed, which was significantly associated with the diagnosis and prognosis of LUAD patients. Thus, the gene signature can be used as a biomarker for LUAD.
Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways
Authors: Huang Jin , Feng Wei , Li Shanshan , Tang Huiling , Qin Siru , Li Wei , Gong Yinan , Fang Yuxin , Liu Yangyang , Wang Shenjun , Guo Yi , Xu Zhifang , Shen Qian 
Published: September 2020

Background:
The antagonistic relationship between adenosine monophosphate-activated protein kinase
(AMPK) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling play a vital role in cancer
development. The anti-cancer effects of berberine have been reported as a main component of the traditional
Chinese medicine Rhizoma coptidis, although the roles of these signaling pathways in these effects have not
been systematically reviewed.

Methods:
We searched the PubMed database for studies with keywords including [“berberine”] and [“tumor”
or “cancer”] and [“AMPK”] or [“AKT”] published between January 2010 and July 2020, to elucidate the roles
of the AMPK and PI3K/AKT pathways and their upstream and downstream targets in the anti-cancer effects of
berberine.

Results:
The anti-cancer effects of berberine include inhibition of cancer cell proliferation, promotion of apoptosis
and autophagy in cancer cells, and prevention of metastasis and angiogenesis. The mechanism of these effects
involves multiple cell kinases and signaling pathways, including activation of AMPK and forkhead box
transcription factor O3a (FOXO3a), accumulation of reactive oxygen species (ROS), and inhibition of the activity
of PI3K/AKT, rapamycin (mTOR) and nuclear factor-κB (NF-κB). Most of these mechanisms converge on
regulation of the balance of AMPK and PI3K/AKT signaling by berberine.

Conclusion:
This evidence supports the possibility that berberine is a promising anti-cancer natural product,
with pharmaceutical potential in inhibiting cancer growth, metastasis and angiogenesis via multiple pathways,
particularly by regulating the balance of AMPK and PI3K/AKT signaling. However, systematic preclinical
studies are still required to provide scientific evidence for further clinical studies.