bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified telehealth for care of chronic wounds during the Coronavirus disease 2019 pandemic: A rapid literature review of alternative care modalities
Authors: Bondini Carla M. , Sage Sarah , Wilson Brent P. , Hall Maire R. , Wallis Elizabeth A. R. 
Published: September 2020

AbstractDue to the changes in delivering medical care during the Coronavirus disease 2019 (COVID‐19) pandemic, such as the heavy reliance on telehealth, it is worth exploring if this is suitable when treating complex wounds. A literature rapid review was performed to explore the existing evidence around alternative service delivery modalities. While there are organisations that have successful telehealth systems and infrastructure, for services that do not already widely use telehealth it is difficult to implement a standardised system in the current state of emergency. The evidence reviewed demonstrates that telehealth appears to currently have a limited place in chronic wound management; therefore, standardisation on determining suitability in conjunction with evaluation of telehealth during this period is needed to shape implementation of telehealth systems in the future.
Composition driven (Ba,Ca)(Zr,Ti)O3 lead‐free ceramics with large quality factor and energy harvesting characteristics
Authors: Bijalwan Vijay , Erhart Jiří , Spotz Zdeněk , Sobola Dinara , Prajzler Vladimír , Tofel Pavel , Maca Karel 
Published: September 2020

AbstractA comprehensive study on energy harvesting characteristics as well as electro‐mechanical properties of lead‐free (1−x)(BaZr0.2Ti0.8)O3—x(Ba0.7Ca0.3Ti)O3 ceramics were systematically carried out. Raman and Rietveld analyses show a formation of rhombohedral‐orthorhombic‐tetragonal (R‐O‐T) phase boundary region between 4/6 BZT/BCT and 6/4 BZT/BCT compositional range. Raman modes shift toward lower frequencies with increased Zr/Ca stoichiometric ratio attributed to asymmetric Ti‐O phonon vibrations, which caused local disorder, widening of energy band and reduced Curie temperature. The large mechanical quality factor Qm = 556 is related to the hardening effect and significantly high energy conversion efficiency η = 96% was discovered for 3/7 BZT/BCT composition. Largely, the noblest electro‐mechanical properties were retrieved for 5/5 BZT/BCT ceramics, in which d33 = 500 pC/N (from quasi‐static d33 meter), d33 = 540 pm/V (from field‐dependent d33 curves) indicating that the both methods are analogous with a deviation of 8%. The outstanding energy harvesting characteristics such as voltage constant g33 = 27 × 10−3 Vm/N, transduction coefficient d33 × g33 = 13 301 × 10−15 m2/N, figure of merit under off‐resonance conditions FOMoff = 12.1 × 10−10 m2/N and fairly large η of 94% were attained again for 5/5 BZT/BCT ceramics. These outstanding characteristics were ascribed to the R‐O‐T phase boundary region that comprises a low energy barrier, consequently facilitated easy polarization rotation and triggered an increased electro‐mechanical conversion. These characteristics outperform other lead‐free and even most commercially available lead‐based ceramics, and thus suitable for sensors, actuators, resonators, and energy harvesting applications.
Persisting in a glaciated landscape: Pleistocene microrefugia evidenced by the tree wētā Hemideina maori in central South Island, New Zealand
Authors: King Keith J. , Lewis Debbie M. , Waters Jonathan M. , Wallis Graham P. 
Published: September 2020

AbstractAimRepeated cycles of Pleistocene glaciation have influenced phylogeographic structure of taxa on New Zealand's South Island. Many taxa became restricted to refugia at either end of the island during glaciation, resulting in an area of low endemicity in central South Island. This area of low endemism is typified by the so‐called beech (or biotic) gap, where the absence of Nothofagus forest (and many other plant and invertebrate taxa) has been attributed to repeated glaciation. Some taxa, however, appear to have persisted in situ in localized refugia within the biotic gap. We test these alternative hypotheses in a large flightless alpine wētā (grasshopper).LocationSouthern Alps, South Island, New Zealand.TaxonHemideina maori Pictet & Saussure, 1891 (Orthoptera: Anostostomatidae).MethodsWe used phylogeographic analysis of mitochondrial cytochrome c oxidase I (cox1) and 25 nuclear DNA (nuDNA) markers to test for Pleistocene glacial microrefugia within the current montane South Island range of Hemideina maori.ResultsWe identified eight deeply differentiated mtDNA lineages with limited sharing of haplotypes among populations. Genetic differentiation assessed using nuDNA revealed a similar pattern, with three groups broadly corresponding to the deepest mtDNA splits. The central South Island region exhibits substantial endemic mtDNA diversity and a distinctive nuclear lineage.Main conclusionsThese results indicate that H. maori likely persisted in microrefugia within the biotic gap during glaciation. These deep lineages are estimated to have started diverging prior to the initiation of glaciation, up to 3 Ma. These results add to a growing number of Southern Hemisphere examples of deep phylogeographic differentiation in glaciated alpine regions compared to Europe and North America, probably reflecting less intense glaciation. We suggest that other Southern Alps species showing northern and southern clades alone are more montane than alpine, and were reliant on warmer habitat to the north and south during glacial eras. Thus, there are species‐specific responses to climatic processes, influenced by distinctive habitat requirements and physiological traits.
miR‐30b Promotes spinal cord sensory function recovery via the Sema3A/NRP‐1/PlexinA1/RhoA/ROCK Pathway
Authors: Wang Xin , Li Bo , Wang Zhijie , Wang Fengyan , Liang Jing , Chen Chuanjie , Zhao Lei , Zhou Bo , Guo Xiaoling , Ren Liqun , Yuan Xin , Chen Xueming , Wang Tianyi 
Published: September 2020

AbstractSpinal cord injury (SCI) induces both motor and sensory dysfunctions. We wondered whether miR‐30b could promote primary sensory neuron (PSN) axon growth in inhibitory microenvironment. The neurite growth was promoted by miR‐30b agomir and inhibited by antagomir. MiR‐30b targeted and degraded sema3A mRNA. MiR‐30b regulated the formation of sema3A‐NRP‐1‐PlexinA1 complex via targeting sema3A. The neurite length was induced by the miR‐30b agomir, and the application of sema3A protein could reverse the effect of agomir. GTP‐RhoA and ROCK expression were down‐regulated by miR‐30b. Neurite outgrowth that inhibited by sema3A and the miR‐30b antagomir was increased by Y‐27632. Agomir promoted neurite growth in NogoA inhibitory conditions, which indicated miR‐30b could both enhance neuronal intrinsic regenerative ability and promote neurite growth against inhibitory microenvironment via Sema3A/NRP‐1/PlexinA1/RhoA/ROCK axis. The agomir could also regulate Sema3A/NRP‐1/PlexinA1/RhoA/ROCK axis in vivo and restore spinal cord sensory conductive function. In conclusion, miR‐30b could be a novel target for sensation recovery after SCI.
KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway
Authors: Su Zhongyuan , Wang Jing , Lai Qinghua , Zhao Huanyu , Hou Ling 
Published: September 2020

AbstractHomeostasis and function of limbal epithelial stem cells (LESCs) rely on the limbal niche, which, if dysfunctional, leads to limbal epithelial stem cell deficiency (LSCD) and impaired vision. Hence, recovery of niche function is a principal therapeutic goal in LSCD, but the molecular mechanisms of limbal niche homeostasis are still largely unknown. Here, we report that the neural crest transcription factor SOX10, which is expressed in neural crest‐derived limbal niche cells (LNCs), is required for LNCs to promote survival of LESCs both in vivo and in vitro. In fact, using mice with a Sox10 mutation and in vitro coculture experiments, we show that SOX10 in LNCs stimulates the production of KIT ligand (KITL), which in turn activates in LESCs the KIT‐AKT signalling pathway that protects the cells against activated CASPASE 3‐associated cell death. These results suggest that SOX10 and the KITL/KIT‐AKT pathway play key roles in limbal niche homeostasis and LESC survival. These findings provide molecular insights into limbal niche function and may point to rational approaches for therapeutic interventions in LSCD.
Diagnostic potential of circulating cell‐free microRNAs for community‐acquired pneumonia and pneumonia‐related sepsis
Authors: Hermann Stefanie , Brandes Florian , Kirchner Benedikt , Buschmann Dominik , Borrmann Melanie , Klein Matthias , Kotschote Stefan , Bonin Michael , Reithmair Marlene , Kaufmann Ines , Schelling Gustav , Pfaffl Michael W. 
Published: September 2020

AbstractCell‐free microRNAs (miRNAs) are transferred in disease state including inflammatory lung diseases and are often packed into extracellular vesicles (EVs). To assess their suitability as biomarkers for community‐acquired pneumonia (CAP) and severe secondary complications such as sepsis, we studied patients with CAP (n = 30), sepsis (n = 65) and healthy volunteers (n = 47) subdivided into a training (n = 67) and a validation (n = 75) cohort. After precipitating crude EVs from sera, associated small RNA was profiled by next‐generation sequencing (NGS) and evaluated in multivariate analyses. A subset of the thereby identified biomarker candidates was validated both technically and additionally by reverse transcription quantitative real‐time PCR (RT‐qPCR). Differential gene expression (DGE) analysis revealed 29 differentially expressed miRNAs in CAP patients when compared to volunteers, and 25 miRNAs in patients with CAP, compared to those with sepsis. Sparse partial‐least discriminant analysis separated groups based on 12 miRNAs. Three miRNAs proved as a significant biomarker signature. While expression levels of miR‐1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR‐193a‐5p and miR‐542‐3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. Cell‐free miRNAs are potentially novel biomarkers for CAP and may help to identify patients at risk for progress to sepsis, facilitating early intervention and treatment.
Bedtime social media use, sleep, and affective wellbeing in young adults: an experience sampling study
Authors: Das‐Friebel Ahuti , Lenneis Anita , Realo Anu , Sanborn Adam , Tang Nicole K. Y. , Wolke Dieter , von Mühlenen Adrian , Lemola Sakari 
Published: September 2020

BackgroundFindings from primarily cross‐sectional studies have linked more extensive social media use to poorer sleep and affective wellbeing among adolescents and young adults. This study examined bedtime social media use, sleep, and affective wellbeing, using an experience sampling methodology with the aim of establishing a day‐to‐day temporal link between the variables. The study hypothesized a positive association between increased bedtime social media use and lower affective wellbeing the following day, mediated by poorer sleep.MethodsUsing a smartphone application, 101 undergraduate students (Mage = 19.70 years, SD = 1.09 years), completed daily questionnaires assessing the previous night’s bedtime social media use and sleep duration and satisfaction (one measurement per day, questionnaire sent at 08:00), and momentary affective wellbeing (five measurements per day, at randomly varying times between 08:00 and 22:00 on weekdays and 10:00 and 22:00 on weekends), for 14 consecutive days. Objective assessments of total sleep time and sleep efficiency were obtained via wrist‐worn actigraphs. By means of separate multilevel models, it was tested whether increased bedtime social media use predicted poorer sleep the same night, whether poorer sleep was predictive of positive and negative affect the following day, and whether sleep mediated the relationship between social media use and affective wellbeing.ResultsIncreased bedtime social media use was not associated with poorer sleep the same night. Apart from subjective sleep satisfaction, no other sleep variable (i.e., subjective sleep duration, objective total sleep time and objective sleep efficiency) predicted positive or negative affect the following day.ConclusionsThis study found that bedtime social media use is not detrimental to the sleep and affective wellbeing of healthy young adults. However, it is possible that bedtime social media use may be harmful to the sleep of vulnerable individuals.
Creeping attachment: A literature review
Authors: Wan Wenjuan , Zhong Heli , Wang Jiawei 
Published: September 2020

AbstractObjectiveMucogingival surgery has been widely applied in clinics. An interesting phenomenon after mucogingival surgery is the coronal migration of gingival margin, which is described as “creeping attachment.” The goal of this review is to summarize the characteristics, significance, mechanism, and manifestation of the creeping attachment after mucogingival surgery and to describe the factors associated with its occurrence.OverviewA total of 82 relevant articles were included in the literature review. The characteristics and significance of the creeping attachment after mucogingival surgery were analyzed. The mechanism of the creeping attachment was explored. Different manifestations of and factors associated with creeping attachment were summarized.ConclusionsCreeping attachment may occur to obtain additional root coverage after the healing of various mucogingival surgeries. However, this coverage is not always complete nor entirely predictable.Clinical SignificanceCreeping attachment plays an important role in the prognosis of mucogingival surgeries. This review will help clinicians get a thorough recognition and understanding of this phenomenon.
Re‐evaluation of reproductive cycle and fecundity of finetooth sharks Carcharhinus isodon (Valenciennes 1839) from the Northwest Atlantic Ocean, with new observations on ovarian cycle and reproductive endocrinology of biennially reproducing sharks
Authors: Brown Amanda N. , Frazier Bryan S. , Gelsleichter Jim 
Published: September 2020

AbstractTo provide updated information on life history for improved fishery management, the reproductive cycle of the finetooth shark Carcharhinus isodon from Northwest Atlantic (NWA) populations was investigated by examining temporal changes in morphology and histology of reproductive organs. Changes in plasma concentrations of gonadal sex hormones in relation to reproductive stage were also examined. Increases in testis width, epididymis head width, plasma testosterone concentrations and occurrence of mature spermatozoa were observed in male sharks between December and April, suggesting a seasonal pattern in reproduction that culminates with copulatory activity in May. Increases in maximum follicular diameter, oviducal gland width, plasma 17β‐estradiol concentrations and occurrence of vitellogenic follicles were observed in non‐pregnant female sharks during the same time period along with the occurrence of newly pregnant females in May, demonstrating strong synchronicity between male and female reproductive cycles. Pregnant females bearing full‐term embryos were also observed in May, indicating that parturition occurs between mid‐May and early June and gestation requires 12 months. Only transient temporal changes in follicle size and oviducal gland width were observed in pregnant females, indicating that reproductive periodicity is biennial; nonetheless, a single female exhibiting signs of concurrent vitellogenesis and pregnancy was observed. Mean brood size ± S.D. was 3.9 ± 0.9 offspring/female. Fecundity was not significantly correlated with female size, in part due to an unexpectedly high rate of early embryo mortality, which occurred in 11% of pregnant females, and was more common in larger individuals. Changes in ovarian activity during mid‐pregnancy were observed, suggesting possible roles for the ovary in regulating some aspects of early to mid‐gestation. This study confirms that earlier characterizations of the reproductive cycle and fecundity in NWA finetooth sharks remain valid for use in fishery management. This study also highlights unusual features of finetooth shark pregnancy (e.g., early embryo death, mid‐pregnancy changes in ovarian function) that may have broader relevance to understanding elasmobranch reproduction.
Metabolic syndrome and its components in people with intellectual disability: a meta‐analysis
Authors: Vancampfort D. , Schuch F. , Van Damme T. , Firth J. , Suetani S. , Stubbs B. , Van Biesen D. 
Published: September 2020

AbstractBackgroundPeople with intellectual disability have an increased risk for cardiovascular diseases and associated premature mortality. Metabolic syndrome (MetS) and its components are highly predictive of cardiovascular diseases. The aim of this meta‐analysis was to describe the pooled prevalence of MetS and its components in people with intellectual disability taking into account variations in demographic, clinical and treatment‐related variables.MethodsPubmed, Embase and CINAHL were searched until 5 August 2020 for studies reporting cross‐sectional data on prevalences of MetS and its components in people with intellectual disability. Two independent reviewers extracted data. Random effects meta‐analyses with subgroup and meta‐regression analyses were employed.ResultsThe pooled MetS prevalence after adjusting for publication bias was 22.5% [95% confidence interval (CI) = 16.8%–29.6%; N studies = 10; n participants = 2443, median age at study level = 38.5 years; 52% male]. Abdominal obesity was observed in 52.0% (95% CI = 42.0%–61.9%; I2 = 86.5; N = 5; n = 844), hypertension in 36.7% (95% CI = 26.1%–48.7%; N = 6; n = 926), hypertriglyceridaemia in 23.5% (95% CI = 18.8%–28.9%; N = 5; n = 845), low high‐density‐lipoprotein‐cholesterol in 23.4% (95% CI = 19.3%–28.0%; N = 6; n = 917), and hyperglycaemia in 10.2% (95% CI = 7.6%–13.3%; N = 5; n = 845). Meta‐regression revealed that a higher MetS frequency was moderated by older age (coefficient = 0.03; standard error = 0.01, 95% CI = 0.008 to 0.055; N = 19; n = 2443) and a higher proportion of people on antidepressants in the study (coefficient = 7.24; standard error = 0.90, 95% CI = 5.48–9.00; N = 4; n = 546). There were insufficient data comparing MetS in people with intellectual disability with age‐matched and gender‐matched controls.ConclusionsConsidering that more than one fifth of people with intellectual disability have MetS, routine screening and multidisciplinary management of metabolic abnormalities in people with intellectual disability is needed. Attention should be given to older people and those on antidepressants.
A systematic review of behaviour analytic interventions for young children with intellectual disabilities
Authors: Ho H. , Perry A. , Koudys J. 
Published: September 2020

AbstractBackgroundAccording to several comprehensive systematic and narrative reviews, interventions based on applied behaviour analysis principles, or behaviour analytic interventions, are considered evidence based for children with autism spectrum disorder (ASD). However, no comprehensive review of the literature related to behaviour analytic interventions for children with intellectual disability (ID) currently exists.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines (registration ID: CRD42018099317), the purpose of this study was to conduct a systematic review of the relevant published literature on the use of behaviour analytic interventions to develop skills in young children (0–8 years) with ID (and without ASD). A preliminary search of the literature identified 1209 potential studies published between January 2000 and April 2020. The review process resulted in 48 articles consisting of 49 studies (i.e. one paper contained two studies) that met the inclusion criteria. Most used single‐case research designs. Studies were evaluated on five dimensions of methodological quality based on the Scientific Merit Rating Scale developed by the National Autism Center (NAC). The NAC definitions were also used for the quantity and quality of research evidence required for interventions to be considered established or emerging.ResultsThere were a number of limitations to the quality of the body of research. Nevertheless, various behaviour analytic interventions met criteria for being established interventions when used for targeting communication, adaptive and pre‐academic skills in young children with ID. Behaviour analytic interventions targeting academic skills met criteria for emerging interventions.ConclusionsAlthough the current literature is limited, results indicate that behaviour analytic interventions may be effectively used to support skill development in children with ID.
Development and Initial Psychometric Testing of the Midwifery Practice Climate Scale
Authors: Thumm E. Brie , Meek Paula 
Published: September 2020

IntroductionPerinatal care in the United States is plagued with a high maternal mortality rate and shortages of perinatal care providers. A supportive practice climate is a theoretically based and empirically demonstrated means of improving the quality of care and stabilizing the workforce; however, there has been limited research into the qualities and measurement of a supportive practice climate for midwives.MethodsWe developed a self‐report instrument, the Midwifery Practice Climate Scale, to measure midwives’ perceptions of the supportiveness of their work environments. We tested content and face validity with 2 samples of content experts (n = 6 and n = 14, respectively).ResultsThirty‐four items were created or adapted from nursing instruments. Two items that included language about physicians were removed based upon relevance and redundancy as a result of content and face validity testing.DiscussionThe findings indicate that the Midwifery Practice Climate Scale is relevant to midwifery and addresses the intended concept of a supportive practice climate for midwives. Challenges of creating the scale identified were language regarding leadership and the varying relationships with physicians across diverse settings. The next stages in testing the Midwifery Practice Climate Scale will address these challenges, as well as test the reliability and construct validity.