bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous adipose-derived stem cells for the treatment of Crohn’s fistula-in-ano: an open-label, controlled trial
Authors: Zhou Chungen , Li Meng , Zhang Yang , Ni Min , Wang Yehuang , Xu Dachao , Shi Yang , Zhang Bo , Chen Yanni , Huang Yan , Zhang Sumin , Shi Hongzhen , Jiang Bin 
Published: March 2020

Abstract
Background
Crohn’s fistula-in-ano is a refractory disease in colorectal and anal surgery. Although autologous adipose-derived stem cell (ADSC) has been used in the treatment of Crohn’s fistula-in-ano because of its convenience, non-incision of normal tissue, good tolerance, repeatability, quick recovery, less pain, less damage to anal function, and high quality of life during the perioperative period, there are no reports of its use in China. This is the first clinical trial in China on the treatment of Crohn’s fistula-in-ano with ADSC to evaluate its efficacy and safety.

Methods
A total of 22 patients with Crohn’s fistula-in-ano were enrolled in this study from January 2018 to October 2018 in the Colorectal Disease Center of Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine. Patients were divided (1:1) into an observation group (ADSC) and a control group (incision-thread-drawing procedure). Primary efficacy endpoint evaluated at months 3, 6, and 12 was the closure of fistulas (closure of all treated fistulas at baseline, confirmed by doctor’s clinical assessment and magnetic resonance imaging or transrectal ultrasonography). The patients additionally completed some scoring scales at each follow-up including simplified Crohn’s Disease Activity Index (CDAI), Perianal Disease Activity Index (PDAI), Inflammatory Bowel Disease Questionnaire (IBDQ), pain scores with visual analog score (VAS), and Wexner score. The data of inflammatory indexes were also collected.

Results
The healing rates of the observation group and the control group at months 3, 6, and 12 were as follows: 10/11(90.9%) vs 5/11(45.5%), 8/11(72.7%) vs 6/11(54.5%), and 7/11(63.6%) vs 6/11(54.5%), respectively. There was no statistical difference between the two groups. In addition, the improvement in simplified CDAI, PDAI, IBDQ, VAS, and Wexner score of the observation group were better than that of the control group at each follow-up. The inflammatory indexes decreased in both the observation group and the control group at 3 months follow-up. And there were no significant differences in the changes of inflammatory indexes between two groups at month 3 compared with the baseline. Safety was maintained throughout month 12, and adverse events occurred in 63.6% of patients in the observation group and 100% patients in the control group. And no adverse event associated with ADSC injection was observed in the study.

Conclusion
ADSC is a feasible and effective treatment for Crohn’s fistula-in-ano, compared with traditional incision and thread-drawing. It can protect anal function of patients, relieve pain, allow quick recovery, be well-tolerated, and improve the quality of life during perioperative period.

Trial registration
China Clinical Trials Registry, No. ChiCTR1800014599. Registered 23 January 2018.
Cognitive interventions for adults with chronic kidney disease: protocol for a scoping review
Authors: Farragher Janine F. , Stewart Katherine E. , Harrison Tyrone G. , Engel Lisa , Seaton Samantha E. , Hemmelgarn Brenda R. 
Published: March 2020

Abstract
Background
Cognitive impairment is a common and frequently under-recognized complication of chronic kidney disease (CKD). Although there is extensive literature on cognitive interventions that can ameliorate cognitive impairment or associated negative outcomes in the general literature, the breadth and characteristics of cognitive interventions that have been studied in people with CKD are currently unclear. The objective of this scoping review is to identify and describe the literature on cognitive interventions for adults with CKD, including end-stage kidney disease (ESKD).

Methods
A scoping review following Joanna Briggs Institute methodology will be conducted. With assistance from an information specialist, we will search 5 electronic databases (MEDLINE [OVID], EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, and CINAHL Plus) using search terms that represent the target population (CKD) and concept (cognition), and conduct backward citation searching for additional literature. Eligible sources will be primary research studies (quantitative or qualitative) that investigate any intervention targeting cognition in adults (≥ 18 years) with CKD or ESKD, including those treated with dialysis. We will extract data about characteristics of interventions (e.g., type, underlying theory, design, location, and provider), populations (e.g., stage of CKD, age, sex, and type of cognitive impairment), and studies (e.g., authors, location, design, and reported findings). Article screening and data extraction will be performed by two to three reviewers. Data will be analyzed using descriptive statistics and narrative syntheses to characterize the literature on cognitive interventions for people with CKD.

Discussion
This study will provide a comprehensive overview of the cognitive interventions that have been studied for people with CKD. It will help identify research gaps within this population (e.g., types of interventions that have yet to be investigated; best practices in cognition research that have not been implemented) and inform the direction of future research in this field.
Different screening frequencies of carbapenem-resistant Enterobacteriaceae in patients undergoing hematopoietic stem cell transplantation: which one is better?
Authors: Yang Ting-Ting , Luo Xue-Ping , Yang Qing , Chen Hong-Chao , Luo Yi , Zhao Yan-Min , Ye Yi-Shan , Lai Xiao-Yu , Yu Jian , Tan Ya-Min , Wei Guo-Qing , Huang He , Shi Ji-Min 
Published: March 2020

AbstractBackgroundA consensus has been reached that carbapenem-resistantEnterobacteriaceae(CRE) screening in immunosuppressed individuals can reduce the incidence of CRE bloodstream infection (BSI).MethodsWe retrospectively studied the clinical data of 395 consecutive HSCT patients from September 2017 to April 2019. From September 2017 to June 2018 (period 1), 200 patients received single CRE screening before transplantation. From July 2018 to April 2019 (period 2), 195 patients received continuous weekly CRE screening after admission. For patients colonized with CRE, targeted managements were received: (1) contact precautions and (2) preemptive CRE-targeted treatment if necessary.ResultsDuring period 1, 3 patients with CRE colonization were detected (1.5%). The CRE BSI rate was 2.0% (4 patients), and the related 30-day mortality was 50.0% (2 out of 4 patients). During period 2, 21 patients with CRE colonization were detected, and the detection rate was significantly higher than that in period 1 (P < 0.001). Of the 21 colonized patients, 4 (19.0%) patients were identified as positive for CRE at the first screening, 5 (23.8%) were identified at the second screening, and the remaining 12 (57.1%) were identified at the third or later screening. The CRE BSI rate decreased to 0.5% (1/195), and there were no CRE-related death.Fifteen colonized patients developed neutropenic fever. Thirteen colonizers were preemptively treated with tigecycline within 24 h of fever onset, and they achieved rapid temperature control. One colonizer received tigecycline later than 48 h after fever onset and ultimately survived due to the addition of polymyxin. The other received tigecycline later than 72 h after fever onset and died of septic shock.ConclusionThe increase in screening frequency contributed to the detection of patients with CRE colonization. Targeted managements for these colonized patients may contribute to reducing the incidence and mortality of CRE BSI, therefore improving the prognosis of patients.
Clinical significance of precedent asymptomatic non-sustained ventricular tachycardias on subsequent ICD interventions and heart failure hospitalization in primary prevention ICD patients
Authors: Makimoto Hisaki , Zielke Sophie , Clasen Lukas , Lin Tina , Gerguri Shqipe , Müller Patrick , Schmidt Jan , Bejinariu Alexandru , Kurt Muhammed , Brinkmeyer Christoph , Stern Manuel , Kelm Malte , Fürnkranz Alexander 
Published: March 2020

Abstract
Background
The prognostic implications of non-sustained ventricular tachycardia (NSVT) and their significance as therapeutic targets in patients without prior sustained ventricular arrhythmias remain undetermined. The aim of this study was to investigate the prognostic significance of asymptomatic NSVT in patients who had primary prevention implantable cardioverter-defibrillator (ICD) implantation due to ischemic or non-ischemic cardiomyopathy (ICM, NICM).

Methods
We enrolled 157 consecutive primary prevention ICD patients without previous appropriate ICD therapy (AIT). Patients were allocated to two groups depending on the presence or absence of NSVT in a 6-month period prior to enrollment. The incidence of AIT and unplanned hospitalization due to decompensated heart failure (HF) were assessed during follow-up.

Results
In 51 patients (32%), precedent NSVT was documented. During a median follow-up of 1011 days, AIT occurred in 36 patients (23%) and unplanned HF hospitalization was observed in 32 patients (20%). In precedent NSVT patients, the incidence of AIT and unplanned HF hospitalization was significantly higher as compared to patients without precedent NSVT (AIT: 29/51 [57%] vs. 7/106 [7%], P < 0.001, log-rank; HF hospitalization: 16/51 [31%] vs. 16/106 [15%], P = 0.043, log-rank). Cox-regression demonstrated that precedent NSVT independently predicted AIT (P < 0.0001). In subgroup analyses, precedent NSVT predicted AIT in both ICM and NICM (P < 0.0001, P = 0.020), but predicted HF hospitalization only in patients with ICM (P = 0.0030).

Conclusions
Precedent non-sustained VT in patients with primary prevention ICDs is associated with subsequent appropriate ICD therapies, and is an independent predictor of unplanned heart failure hospitalizations in patients with ischemic cardiomyopathy.
Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis
Authors: Cheragh-Birjandi Sadegh , Moghbeli Meysam , Haghighi Farideh , Safdari Mohammad Reza , Baghernezhad Maryam , Akhavan Arash , Ganji Reza 
Published: March 2020

Abstract
Background
Osteoarthritis is the most common joint damage that leads to cartilage destruction, pain, and disability. The aim of this study is to investigate the effects of resistance exercises and Nano curcumin supplementation on synovial levels of collagenase-2 and NO in patients with knee osteoarthritis.

Methods
Forty women with primary knee osteoarthritis were divided into four groups including control, exercise, supplementation, and supplementation /exercises. The resistance exercise group performed exercises in 16 weeks (three sessions per week). The supplement group consumed one Nano curcumin capsule (1000 mg) per day for 16 weeks. Exercise and supplementation group also performed resistance exercises along with consuming Nano curcumin. Synovial fluid samplings were done in two stages of pre-test (24 h before training and supplementation) and post-test (48 h after the last session of treatment and supplementation). The obtained synovial fluid was used to measure the synovial level of collagenase -II and nitric oxide.

Results
Although, there were not any significant correlations between resistance exercise, nanocurcumum supplementation, and synovial levels of collagenase-2 and NO among women with knee osteoarthritis, we observed interesting reduced levels of both markers following the supplementation.

Conclusions
It can be concluded that the Nano curcumin supplementation can be an effective method to reduce the levels of these inflammatory factors in synovial fluids of cases with knee Osteoarthritis. Longer duration of the protocol may have more promoting results.

Trial registration
The project was registered at Iranian Registry of Clinical Trials (Trial registration number: IRCT20161208031300N1).
Modeling the seismic response of individual hydraulic fracturing stages observed in a time-lapse distributed acoustic sensing vertical seismic profiling survey
Authors: Binder Gary , Titov Aleksei , Liu Youfang , Simmons James , Tura Ali , Byerley Grant , Monk David 
Published: March 2020

In 2017, distributed acoustic sensing (DAS) technology was deployed in a horizontal well to conduct a vertical seismic profiling survey before and after each of 78 hydraulic fracturing stages. From two vibroseis source locations at the surface, time shifts of P- and S-waves were observed but decayed over days. Some stages also showed waves scattered off the stimulated rock volume. We have used 2D finite difference elastic wavefield modeling to understand these observations and connect them to underlying properties of the stimulated rock. We have developed an effective medium model of vertical fractures that close exponentially with time as fluid leaks off into the formation can match the distribution of P- and S-wave time shifts along the well. This has enabled estimates of the height, normal and tangential fracture compliance values, and decay time of the stimulated rock volume. Additionally, the kinematics of scattered waves observed in the data have been found to be consistent with PS conversion across the stimulated rock volume from an individual stage. With higher quality DAS data, stage-by-stage inversion for height, fracture compliance, and decay time attributes may be possible for characterizing variations in the effectiveness of hydraulic fracturing.
Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors
Authors: Desai Jayesh , Gan Hui , Barrow Catherine , Jameson Michael , Atkinson Victoria , Haydon Andrew , Millward Michael , Begbie Stephen , Brown Michael , Markman Ben , Patterson William , Hill Andrew , Horvath Lisa , Nagrial Adnan , Richardson Gary , Jackson Christopher , Friedlander Michael , Parente Phillip , Tran Ben , Wang Lai , Chen Yunxin , Tang Zhiyu , Huang Wendy , Wu John , Zeng Dewan , Luo Lusong , Solomon Benjamin 
Published: March 2020

PURPOSE Lifirafenib is an investigational, reversible inhibitor of B-RAFV600E, wild-type A-RAF, B-RAF, C-RAF, and EGFR. This first-in-human, phase I, dose-escalation/dose-expansion study evaluated the safety, tolerability, and efficacy of lifirafenib in patients with B-RAF– or K-RAS/N-RAS–mutated solid tumors. METHODS During dose escalation, adult patients with histologically/cytologically confirmed advanced solid tumors received escalating doses of lifirafenib. Primary end points were safety/tolerability during dose escalation and objective response rate in preselected patients with B-RAF and K-RAS/N-RAS mutations during dose expansion. RESULTS The maximum tolerated dose was established as 40 mg/d; dose-limiting toxicities included reversible thrombocytopenia and nonhematologic toxicity. Across the entire study, the most common grade ≥ 3 treatment-emergent adverse events were hypertension (n = 23; 17.6%) and fatigue (n = 13; 9.9%). One patient with B-RAF–mutated melanoma achieved complete response, and 8 patients with B-RAF mutations had confirmed objective responses: B-RAFV600E/K melanoma (n = 5, including 1 patient treated with prior B-RAF/MEK inhibitor therapy), B-RAFV600E thyroid cancer/papillary thyroid cancer (PTC; n = 2), and B-RAFV600E low-grade serous ovarian cancer (LGSOC; n = 1). One patient with B-RAF–mutated non–small-cell lung cancer (NSCLC) had unconfirmed partial response (PR). Patients with K-RAS–mutated endometrial cancer and K-RAS codon 12–mutated NSCLC had confirmed PR (n = 1 each). No responses were seen in patients with K-RAS/N-RAS–mutated colorectal cancer (n = 20). CONCLUSION Lifirafenib is a novel inhibitor of key RAF family kinases and EGFR, with an acceptable risk-benefit profile and antitumor activity in patients with B-RAFV600–mutated solid tumors, including melanoma, PTC, and LGSOC, as well as K-RAS–mutated NSCLC and endometrial carcinoma. Future comparisons with first-generation B-RAF inhibitors and exploration of lifirafenib alone or as combination therapy in patients with selected RAS mutations who are resistant/refractory to first-generation B-RAF inhibitors are warranted.
Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival
Authors: Vera-Yunca Diego , Girard Pascal , Parra-Guillen Zinnia P. , Munafo Alain , Trocóniz Iñaki F. , Terranova Nadia 
Published: March 2020

AbstractTotal tumor size (TS) metrics used in TS models in oncology do not consider tumor heterogeneity, which could help to better predict drug efficacy. We analyzed individual target lesions (iTLs) of patients with metastatic colorectal carcinoma (mCRC) to determine differences in TS dynamics by using the ClassIfication Clustering of Individual Lesions (CICIL) methodology. Results from subgroup analyses comparing genetic mutations and TS metrics were assessed and applied to survival analyses. Data from four mCRC clinical studies were analyzed (1781 patients, 6369 iTLs). CICIL was used to assess differences in lesion TS dynamics within a tissue (intra-class) or across different tissues (inter-class). First, lesions were automatically classified based on their location. Cross-correlation coefficients (CCs) determined if each pair of lesions followed similar or opposite dynamics. Finally, CCs were grouped by using the K-means clustering method. Heterogeneity in tumor dynamics was lower in the intra-class analysis than in the inter-class analysis for patients receiving cetuximab. More tumor heterogeneity was found in KRAS mutated patients compared to KRAS wild-type (KRASwt) patients and when using sum of longest diameters versus sum of products of diameters. Tumor heterogeneity quantified as the median patient’s CC was found to be a predictor of overall survival (OS) (HR = 1.44, 95% CI 1.08–1.92), especially in KRASwt patients. Intra- and inter-tumor tissue heterogeneities were assessed with CICIL. Derived metrics of heterogeneity were found to be a predictor of OS time. Considering differences between lesions’ TS dynamics could improve oncology models in favor of a better prediction of OS.
Can we rely on adolescents to self-assess puberty stage? A systematic review and meta-analysis
Authors: Campisi Susan C , Marchand Josée D , Siddiqui Fahad Javaid , Islam Muhammad , Bhutta Zulfiqar A , Palmert Mark R 
Published: March 2020

Abstract

Context
Clinicians, researchers, and global health advocates often include pubertal development in outcomes. However, assessments of pubertal stage can be challenging because of the sensitive nature and feasibility of clinical examinations, especially in larger settings.

Objective
To determine the accuracy of self-assessed Tanner staging when compared with physically assessed Tanner stages by a clinician.

Data Sources
MEDLINE, PubMed, Embase, Web of Science, Scopus, the Cochrane Library, CINAHL.

Study Selection
Studies were included if they reported 5 × 5 tables of self-assessment compared to clinician–assessment for the 5-stage Tanner scale.

Data Extraction
We extracted data to generate complete 5 × 5 tables for each study, including any subgroup eligible for the analysis, such as overweight/obese youth.

Data Synthesis
After screening, 22 studies representing 21,801 participants met our inclusion criteria for the meta-analysis. Overall agreement was moderate or substantial between the 2 assessments, with breast stage 1, female pubic hair 1, male pubic hair 1, and male pubic hair 5 having the highest agreement. When stages were collapsed into pre- (Tanner stage 1), in (stages 2,3), and completing (stages 4,5) puberty, levels of agreement improved, especially for pre- and completing pubertal development. Most included studies comprised Caucasian youth. More studies are needed which include a broader range of geographic and socioeconomic settings, as well as a greater diversity of racial/ethnic groups.

Conclusions
Self-assessment of puberty is most accurate when identifying Tanner stage 1, Tanner stage 5 and when development is categorized into prepuberty, in, and completing puberty phases. Use of self-assessment data should be structured accordingly.

Protocol Registration
PROSPERO # CRD42018100205
CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division
Authors: Peterman Eric , Valius Mindaugas , Prekeris Rytis 
Published: March 2020

ABSTRACT
During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. Although the regulators of cytokinetic ring formation and contraction are well established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of the sub-plasma-membrane actomyosin network within the furrow by recruiting MST4 kinase (also known as STK26) and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during the late stages of cytokinetic furrowing.
Observation of a comb of squeezed states with a strong squeezing factor by a bichromatic local oscillator
Authors: Shi Shaoping , Wang Yajun , Tian Long , Wang Jinrong , Sun Xiaocong , Zheng Yaohui 
Published: March 2020

We demonstrate the experimental detection of an optical squeezing covering several higher resonances of the optical parametric amplifier (OPA) by adopting a bichromatic local oscillator (BLO). The BLO is generated from a waveguide electro-optic phase modulator (WGM) and subsequent optical mode cleaner (OMC), without the need of additional power balance and phase control. The WGM is used for generating the frequency-shifted sideband beams with equal power and certain phase difference, and the OMC is used for filtering the unwanted optical modes. Among a measurement frequency range from 0 to 16.64 GHz, the maximum squeezing factors are superior to 10 dB below the shot noise limit for the first three discrete odd-order resonances of the OPA.
Evaluating ERP System Merging Success In Chemical Companies: System Quality, Information Quality, And Service Quality
Authors: Gaol Ford Lumban , Puryasana Intan , Matsuo Tokuro 
Published: March 2020

Abstract
This study is aimed to analyze success of the Enterprise Resource Planning (ERP) System Merging in Chemical Company Singapore that acquired two companies. The success component of ERP system success is using DeLone and McLean success model with qualitative method. The research methodology used detail interview with project implementation team, ERP consultants (8 informants) to get more detail from ERP system merging with information and collected supporting data from the ERP system itself. The result shows that ERP System Merging succeed to increase the system quality of Chemical Company which acquired two companies into one ERP system. It was depicted by the increment of easiness on using the system. The information much more integrated and accurate after the ERP system merging. Meanwhile service quality was increased because of all incidents now monitored in one efficient log system and handled by experienced IT application support team.