bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical determinants of low handgrip strength and its decline in the oldest old: the Leiden 85-plus Study
Authors: Ling Carolina H. Y. , Gussekloo Jacobijn , Trompet Stella , Meskers Carel G. M. , Maier Andrea B. 
Published: June 2020

Abstract
Background
Age-related decline in muscle strength, dynapenia, is linked to serious adverse health outcomes. Evidence on the determinants of muscle strength decline in the oldest old is lacking.

Aims
To identify clinical variables associated with handgrip strength and its change over a 4-year period in an oldest old cohort.

Methods
We included 555 participants from the Leiden 85-plus Study, a prospective population-based study of 85-year-old inhabitants of Leiden, the Netherlands. Handgrip strength was assessed at age 85 and 89 years. Anthropometry, mental status, functional performance, and biochemical variables were obtained at baselines. Significant univariates were included into multivariable regression models to extract the final predictive variables.

Results
Handgrip strength for men and women at age 85 years was 30.6 kg (SD 8.2) and 18.7 kg (SD, 5.5), respectively. In the cross-sectional analysis, body height and weight were positively associated with handgrip strength in both genders. Higher functional performance was associated with stronger handgrip strength in women. Mean absolute handgrip strength decline over 4 years was greater for men than women (− 6.1 kg (SD, 5.2) vs. − 3.4 kg (SD, 4.1), p < 0.001). Men with better baseline cognitive functioning had smaller decline in handgrip strength.

Conclusions
This study further strengthens evidence linking functional and cognitive performances to muscle strength in the oldest old. Future research is needed to ascertain causality and determine if these markers represent potential targets for intervention.
Computational modelling of metal soap formation in historical oil paintings: the influence of fatty acid concentration and nucleus geometry on the induced chemo-mechanical damage
Authors: Eumelen G. J. A. M. , Bosco E. , Suiker A. S. J. , Hermans J. J. , van Loon A. , Keune K. , Iedema P. D. 
Published: June 2020

AbstractMetal soap formation is one of the most wide-spread degradation mechanisms observed in historical oil paintings, affecting works of art from museum collections worldwide. Metal soaps develop from a chemical reaction between metal ions present in the pigments and saturated fatty acids, which are released by the oil binder. The presence of large metal soap crystals inside paint layers or at the paint surface can be detrimental for the visual appearance of artworks. Moreover, metal soaps can possibly trigger mechanical damage, ultimately resulting in flaking of the paint. This paper departs from a recently proposed computational model to predict chemo-mechanical degradation in historical oil paintings, as presented in Eumelen et al. (J Mech Phys Solids 132:103683, 2019). The model describes metal soap formation and growth, which are phenomena that are driven by the diffusion of saturated fatty acids and proceed by a nucleation process from a crystalline nucleus of small size. This results into a chemically-induced strain in the paint, which may promote crack nucleation and propagation. The proposed model is here used to investigate the effects of saturated fatty acid concentration and initial nucleus geometry on the amount of chemo-mechanical damage generated. Numerical simulations show that both factors have a marginal influence on the growth rate of the metal soap crystal, but play a significant role on the extent of fracture induced in the paint.
Spatial and time resolved determination of the vibrational temperature in ignition sparks by variation of the dwell time
Authors: Michler Tobias , Toedter Olaf , Koch Thomas 
Published: June 2020

AbstractThe ignition process initiates the combustion in spark-ignition engines. Therefore, understanding the ignition process is an important aspect in developing more efficient combustion engines. In this thesis, the vibrational temperature of an ignition spark in air under atmospheric pressure and room temperature is observed in spatial and temporal resolution. The temperature is determined by comparing simulated spectra with the measured spectra of the second positive system of N2 between 360 and 381 nm. Changing the dwell time had no significant effect on the vibrational temperature of the three spark phases. In the breakdown the vibrational temperature is about 3300 K. The vibrational temperature of the following arc discharge is in the range of 3750 K to 4350 K. The glow discharge is divided into the negative glow and the positive column. Both show similar vibration temperatures in the range of 3500 K to 3900 K.
Observations of exponential wave attenuation in Antarctic sea ice during the PIPERS campaign
Authors: Kohout Alison L. , Smith Madison , Roach Lettie A. , Williams Guy , Montiel Fabien , Williams Michael J. M. 
Published: June 2020

AbstractQuantifying the rate of wave attenuation in sea ice is key to understanding trends in the Antarctic marginal ice zone extent. However, a paucity of observations of waves in sea ice limits progress on this front. We deployed 14 waves-in-ice observation systems (WIIOS) on Antarctic sea ice during the Polynyas, Ice Production, and seasonal Evolution in the Ross Sea expedition (PIPERS) in 2017. The WIIOS provide in situ measurement of surface wave characteristics. Two experiments were conducted, one while the ship was inbound and one outbound. The sea ice throughout the experiments generally consisted of pancake and young ice <0.5 m thick. The WIIOS survived a minimum of 4 d and a maximum of 6 weeks. Several large-wave events were captured, with the largest recorded significant wave height over 9 m. We find that the total wave energy measured by the WIIOS generally decays exponentially in the ice and the rate of decay depends on ice concentration.
An Implicit Plan Still Overrides an Explicit Strategy During Visuomotor Adaptation Following Repetitive Transcranial Magnetic Stimulation of the Cerebellum
Authors: Voets Sarah H. E. M. , Panouilleres Muriel T. N. , Jenkinson Ned 
Published: June 2020

AbstractMotor adaptation is a process by which the brain gradually reduces error induced by a predictable change in the environment, e.g., pointing while wearing prism glasses. It is thought to occur via largely implicit processes, though explicit strategies are also thought to contribute. Research suggests a role of the cerebellum in the implicit aspects of motor adaptation. Using non-invasive brain stimulation, we sought to investigate the involvement of the cerebellum in implicit motor adaptation in healthy participants. Inhibition of the cerebellum was attained through repetitive transcranial magnetic stimulation (rTMS), after which participants performed a visuomotor-rotation task while using an explicit strategy. Adaptation and aftereffects of the TMS group showed no difference in behaviour compared to a Sham stimulation group, therefore this study did not provide any further evidence of a specific role of the cerebellum in implicit motor adaptation. However, our behavioral findings replicate those in the seminal study by Mazzoni and Krakauer (2006).
Ghosts and Miracles: The Volkswagen as Imperial Debris in Postwar West Germany
Authors: Scholz Natalie 
Published: June 2020

AbstractStarting with the author's own experience of ghostliness in the archive, the article explores the political meaning of the postwar Volkswagen in West Germany as embodiment of the country's “economic miracle.” The investigation follows the uncanny in texts and images about the Volkswagen between 1945 and 1960 and argues that the car carried with it a “public secret” as a “debris” from the Nazi empire that silently transcended the 1945 divide. This reading of the Volkswagen as well as the methodological path toward it highlight a phenomenon that postcolonial scholars have described as “haunting”: a confusion about the relationship between past and present that also bears on those who study the past. Taking this analysis as an encouragement to revisit the powerful myths and “miracles” of postwar consumer cultures in the West from a new angle, the article calls for historical genealogies of these myths that conceive of the postwar West as a—not yet—postcolonial space and that cross the 1945 threshold.
Laboratory findings and a combined multifactorial approach to predict death in critically ill patients with COVID-19: a retrospective study
Authors: Liu Q. , Song N. C. , Zheng Z. K. , Li J. S. , Li S. K. 
Published: June 2020

Abstract
To describe the laboratory findings of cases of death with coronavirus disease 2019 (COVID-19) and to establish a scoring system for predicting death, we conducted this single-centre, retrospective, observational study including 336 adult patients (≥18 years old) with severe or critically ill COVID-19 admitted in two wards of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, who had definite outcomes (death or discharge) between 1 February 2020 and 13 March 2020. Single variable and multivariable logistic regression analyses were performed to identify mortality-related factors. We combined multiple factors to predict mortality, which was validated by receiver operating characteristic curves. As a result, in a total of 336 patients, 34 (10.1%) patients died during hospitalisation. Through multivariable logistic regression, we found that decreased lymphocyte ratio (Lymr, %) (odds ratio, OR 0.574, P < 0.001), elevated blood urea nitrogen (BUN) (OR 1.513, P = 0.009), and raised D-dimer (DD) (OR 1.334, P = 0.002) at admission were closely related to death. The combined prediction model was developed by these factors with a sensitivity of 100.0% and specificity of 97.2%. In conclusion, decreased Lymr, elevated BUN, and raised DD were found to be in association with death outcomes in critically ill patients with COVID-19. A scoring system was developed to predict the clinical outcome of these patients.
From checking the door to checking the app: assessment and treatment implications for obsessive–compulsive disorder in the digital era
Authors: Carmi Lior , Zohar Joseph , Arush Oded Ben , Morein-Zamir Sharon 
Published: June 2020

AbstractIn the last 20 years, technology is increasingly integrated into daily life. Daily interactions with smart devices have become routine with much of our lives taking place in a digital environment. It is therefore not surprising that the manifestations of psychiatric disorders including Obsessive–Compulsive Disorder have changed in recent years reflecting this reality. Clinicians should be aware of the potential impact of such changes when considering symptom presentation and diagnosis.
THE EFFICACY CONDITION
Authors: Adams Thomas 
Published: June 2020

ABSTRACT“A legal system exists,” Joseph Raz claims, “if and only if it is in force.” By this he means to suggest that the efficacy of law—that is, its capacity to control the population to which it applies—is necessary for its identity as such. Despite widespread recognition that efficacy is a condition of the existence of law, however, little time has been spent analyzing the notion. This article begins an attempt to make up the deficit. I make the case for efficacy as necessary for law and go on to develop and defend an account of the concept that is broadly Kelsenian in spirit. In doing so I address questions concerning the relationship between obedience and enforcement in an account of the existence of a legal system as well as relating the discussion to that concerning the ontological status of international law.
Surrounding the Sacred Space: Two Painted Scrolls from the Collection of Namgyal Monastery in Mustang, Nepal
Authors: BELLINI CHIARA 
Published: June 2020

AbstractThe Collection of Namgyal Monastery (Mustang, Nepal) preserves two long and narrow scrolls painted on both sides, of exquisite artistic quality. This article describes and investigates the iconographic and symbolic meaning of the paintings and the use of these objects. One of the scrolls shows the Eight Auspicious Symbols and deities that personify diverse group of offerings painted in an elegant Newari style. The other scroll features an intriguing representation of the Eight Charnel Grounds in a continuous landscape. Full of delicate and charming details, it illustrates theMahasiddhas, Guardians, Nāgas and stupa of the respective directions. The back of both scrolls has a vajra chain at the bottom and flames represented above it. The scrolls must have been used to encircle specific mandalas. Such objects are rather rare, and it is interesting to reflect on their former use, even more so as no contemporaneous objects of that type are known. The stylistic features of the paintings reveal the broader relationships of the Mustang region to neighbouring areas. Relationships can also be established to objects preserved in the same collection, such as a collection of metal stupa of similar design and typical for the Mustang region and the western Himalayas.
Analysis of a Gigantic Jet in Southern China: Morphology, Meteorology, Storm Evolution, Lightning, and Narrow Bipolar Events
Authors: Yang Jing , Qie Xiushu , Zhong Lihua , He Qijia , Lu Gaopeng , Wang Zhichao , Wang Yu , Liu Ningyu , Liu Feifan , Peng Kang‐Ming , Zhu Baoyou , Huang Anjing , Sato Mitsuteru , Pan Huien , Li Hualong 
Published: June 2020

AbstractAt about 22:43:30 BJT (Beijing Time = UTC + 8) on 13 August 2016, two amateur astronomers in Shikengkong, Guangdong province, and Jiahe County, Hunan province, respectively, fortuitously captured a gigantic jet (GJ) event simultaneously, and the GJ exact location could be triangulated. The parent thunderstorm was in a very humid environment (Precipitable Water [PWAT] in excess of 60 mm), featuring high convective available potential energy (CAPE of 2,428 J/kg). The GJ occurred in the region with the coldest cloud top brightness temperature of −64 °C, suggesting the GJ was associated with strong vertical development of the thunderstorm. The vertical cross sections of radar reflectivity also show that the GJ occurred near the thunderstorm strong convection region (overshooting top). The negative cloud‐to‐ground flashes dominated during the thunderstorm evolution. Three positive narrow bipolar events (NBEs) were detected within 30 s before and after the GJ. It indicates that the NBEs were occurred in the upper and middle layers of the thunderstorm (altitude of 11–13 km) with radar reflectivity of 30–35 dBZ.
Kinematic Variation Within the Fars Arc, Eastern Zagros, and the Development of Fold‐and‐Thrust Belt Curvature
Authors: Edey A. , Allen M. B. , Nilfouroushan F. 
Published: June 2020

AbstractWe analyze deformation of the Fars Arc in the eastern Zagros, Iran, including earthquake slip vectors, GPS velocities, paleomagnetism data, and fold orientations, to understand how this fold‐and‐thrust belt works and so better understand the generic issue of fold‐and‐thrust belt curvature. The Fars Arc is curved, convex southward. GPS‐derived rotation rates are ≤0.5° Myr−1: Rotation is clockwise west of 53°E and counterclockwise to the east. These rotation senses are opposite to previous predictions of passive “bookshelf” models for strike‐slip faults during north‐south convergence. West of 53°E, average GPS vectors, thrust earthquake slip vectors, strain axes derived from GPS data, and orthogonal directions to fold trends are all aligned, toward ~218°. East of this meridian, the average GPS vector is toward 208°, but the averages of the other data sets are distinctly different, all toward ~190°. We propose that fault blocks in eastern Fars, each ~20–40 km long, rotate predominantly counterclockwise, whereas in western Fars, the regional clockwise rotation takes place mainly on the array of active right‐lateral faults in this area. Thus, localized block faulting and rotations accumulate to produce the overall strain and regional curvature. Active folds of different orientations in eastern Fars intersect to produce domal interference patterns, without involving separate deformation phases, indicating that fold interference patterns should not be interpreted in terms of changing stress orientations unless there is clear evidence. Fars Arc curvature is best explained by deformation being restricted at tectonic boundaries at its eastern and western margins, with significant gravitational spreading.
Depth‐Scanning Algorithm: Accurate, Automatic, and Efficient Determination of Focal Depths for Local and Regional Earthquakes
Authors: Yuan Jianlong , Kao Honn , Yu Jiashun 
Published: June 2020

AbstractPrecise source depths are critical to the understanding and interpretation of many seismological and tectonic processes. However, conventional earthquake location methods based on the arrival times of direct P and S phases have far less constraint on focal depths than on epicenters. Therefore, developing a method that can systematically and efficiently estimate focal depths with high accuracy, especially for the vast number of small earthquakes that can only be observed at local and regional distances, would make significant contributions to the geoscience research community. In this study, we develop a new method, named “Depth‐Scanning Algorithm,” to efficiently identify depth phases at local and regional distances. We first construct template waveforms of possible depth phases by applying various phase shifts to the original P and S waveforms to mimic the effect of reflection(s). We then systematically scan waveforms after the P and S phases for segments that match the depth‐phase templates. The arrival times of those segments are compared to the theoretical arrival times of depth phases predicted with an assumed velocity model and focal depth. We repeat the above process for a range of assumed focal depths, and the one most consistent with the theoretical prediction is deemed the final solution. Synthetic tests and applications to real data demonstrate the merits of our method compared to conventional location methods.
Carbon Fixation by Photosynthetic Mats Along a Temperature Gradient in a Tengchong Hot Spring
Authors: Zhang Yidi , Qi Xiao , Wang Shang , Wu Geng , Briggs Brandon R. , Jiang Hongcheng , Dong Hailiang , Hou Weiguo 
Published: June 2020

AbstractGeothermal hot springs, widely distributed on Earth, are important geological greenhouse gas sources which contribute large amounts of CO2 emission to the atmosphere. Exploring microbial carbon fixation in these springs is vital to fully understand the carbon budget in these terrestrial aquatic systems. In this study, carbon fixation rate by photosynthetic mats was determined with a 13C‐labeling approach along a gradient of temperature (~69– ~75 °C) in a geothermal pool at Rehai Park in Tengchong, Yunnan Province, China. Light experiments were performed to determine carbon fixation rate by both photosynthesis and chemosynthesis, while dark experiments were performed by chemosynthesis. The results showed that the highest carbon fixation rate (4,637 μg C/g TOC/hr) was obtained in light at the lowest temperature (~69 °C) in the afternoon (1:00 to 6:00 p.m.), most of which (96.7%) was contributed by photosynthesis. The lowest carbon fixation rate (138 μg C/g TOC/hr) was measured at the highest temperature (~75 °C), where chemosynthesis dominated over photosynthesis in carbon fixation. At these rates, the photosynthetic mats would fix 80% of CO2 emission during the daytime. At the end of daytime, the photosynthetic mats respired 34–70% of newly fixed organic carbon in 1 hr. Interestingly, both the carbon fixation rate and respiration rate decreased exponentially with increasing temperature, which may be ascribed to a temperature dependence of both microbial community composition and enzymatic activity. In summary, our study revealed that biological carbon fixation by photosynthetic mats is highly temperature dependent and significantly affects carbon cycling in hot springs.
Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy
Authors: Lee Jong Min , Choi Ji Wook , Ahrberg Christian D. , Choi Hyung Woo , Ha Jang Ho , Mun Seok Gyu , Mo Sung Joon , Chung Bong Geun 
Published: June 2020

AbstractDespite their simplicity, monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix interactions. In contrast, cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug behavior. However, the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell cultures. Here, we present a droplet-based microfluidic device for the automated, large-scale generation of homogenous cell spheroids in a uniform manner. Using the microfluidic system, the size of the spheroids can be tuned to between 100 and 130 μm with generation frequencies of 70 Hz. We demonstrated the photothermal therapy (PTT) application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol (rGO-BPEI-PEG) nanocomposite as the PTT agent. Furthermore, we generated uniformly sized neural stem cell (NSC)-derived neurospheres in the droplet-based microfluidic device. We also confirmed that the neurites were regulated by neurotoxins. Therefore, this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.
Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis
Authors: Conen Silke , Gregory Catherine J. , Hinz Rainer , Smallman Richard , Corsi-Zuelli Fabiana , Deakin Bill , Talbot Peter S. 
Published: June 2020

AbstractPositron emission tomography (PET) imaging of the 18 kDa translocator protein (TSPO), which is upregulated in activated microglia, is a method for investigating whether immune activation is evident in the brain of adults with schizophrenia. This study aimed to measure TSPO availability in the largest patient group to date, and to compare it between patients with recent onset (ROS) and established (ES) schizophrenia. In total, 20 ROS patients (14 male), 21 ES (13 male), and 21 healthy controls completed the study. Patients were predominantly antipsychotic-medicated. Participants underwent a PET scan using the TSPO-specific radioligand [11C](R)-PK11195. The primary outcome was binding potential (BPND) in the anterior cingulate cortex (ACC). Secondary outcomes were BPND in six other regions. Correlations were investigated between TSPO availability and symptom severity. Data showed that mean BPND was higher in older (ES and controls) compared with younger (ROS and controls) individuals, but did not significantly differ between ROS or ES and their respective age-matched controls (ACC; ANOVA main effect of diagnosis: F1,58 = 0.407, p = 0.526). Compared with controls, BPND was lower in antipsychotic-free (n = 6), but not in medicated, ROS patients. BPND in the ES group was negatively correlated with positive symptoms, and positively correlated with negative symptom score. Our data suggest ageing is associated with higher TSPO but a diagnosis of schizophrenia is not. Rather, subnormal TSPO levels in drug-free recent-onset patients may imply impaired microglial development and/or function, which is counteracted by antipsychotic treatment. The development of novel radioligands for specific immune-mechanisms is needed for further clarification.