bluuebunny/crossref_metadata_2025_split huggingface dataset:
High variability between regional histories of long-term atmospheric Pb pollution
Authors: Longman Jack , Ersek Vasile , Veres Daniel 
Published: December 2020

AbstractThe advent of metal processing was one of the key technological evolutions presaging the development of modern society. However, the interplay between metal use and the long-term changes it induced in the development and functioning of past societies remains unclear. We present a compilation of global records of anthropogenic atmospheric lead (Pb) spanning the last 4000 years, an effective indirect proxy for reliably assessing Pb emissions directly linked to human activities. Separating this global Pb pollution signal into regionally representative clusters allows identification of regional differences in pollution output that reflect technological innovations, market demands, or demise of various human cultures for last 4000 years. Our European reconstruction traces well periods of intensive metal production such as the Roman and Medieval periods, in contrast to clusters from the Americas, which show low levels of atmospheric Pb until the Industrial Revolution. Further investigation of the European synthesis results displays clear regional variation in the timing and extent of past development of polluting activities. This indicates the challenges of using individual reconstructions to infer regional or global development in Pb output and related pollution.
Differences in cortical structure between cognitively normal East Asian and Caucasian older adults: a surface-based morphometry study
Authors: Kang Dong Woo , Wang Sheng-Min , Na Hae-Ran , Park Sonya Youngju , Kim Nak Young , Lee Chang Uk , Kim Donghyeon , Son Seong-Jin , Lim Hyun Kook 
Published: December 2020

AbstractThere is a growing literature on the impact of ethnicity on brain structure and function. Despite the regional heterogeneity in age-related changes and non-uniformity across brain morphometry measurements in the aging process, paucity of studies investigated the difference in cortical anatomy between the East Asian and Caucasian older adults. The present study aimed to compare cortical anatomy measurements, including cortical thickness, volume and surface area, between cognitively normal East Asian (n = 171) and Caucasian (n = 178) older adults, using surface-based morphometry and vertex-wise group analysis of high-dimensional structural magnetic resonance imaging (MRI) data. The East Asian group showed greater cortical thickness and larger cortical volume in the right superior temporal gyrus, postcentral gyrus, bilateral inferior temporal gyrus, and inferior parietal cortex. The Caucasian group showed thicker and larger cortex in the left transverse temporal cortex, lingual gyrus, right lateral occipital cortex, and precentral gyrus. Additionally, the difference in surface area was discordant with that in cortical thickness. Differences in brain structure between the East Asian and Caucasian might reflect differences in language and information processing, but further studies using standardized methods for assessing racial characteristics are needed. The research results represent a further step towards developing a comprehensive understanding of differences in brain structure between ethnicities of older adults, and this would enrich clinical research on aging and neurodegenerative diseases.
Novel tonometer device distinguishes brain stiffness in epilepsy surgery
Authors: Fallah Aria , Subramaniam Thirusivapragasam , Phillips H. Westley , Michalet Xavier , Vinters Harry V. , Yong William H. , Wu Joyce Y. , Salamon Noriko , Ellingson Benjamin M. , Wang Anthony C. , Reyes Samuel D. , Ibrahim George M. , Weil Alexander G. , Chang Julia W. , Babayan Diana , Nguyen Jimmy C. , Behnke Eric , Tseng Chi-Hong , Mathern Gary W. 
Published: December 2020

AbstractComplete surgical resection of abnormal brain tissue is the most important predictor of seizure freedom following surgery for cortical dysplasia. While lesional tissue is often visually indiscernible from normal brain, anecdotally, it is subjectively stiffer. We report the first experience of the use of a digital tonometer to understand the biomechanical properties of epilepsy tissue and to guide the conduct of epilepsy surgery. Consecutive epilepsy surgery patients (n = 24) from UCLA Mattel Children’s Hospital were recruited to undergo intraoperative brain tonometry at the time of open craniotomy for epilepsy surgery. Brain stiffness measurements were corrected with abnormalities on neuroimaging and histopathology using mixed-effects multivariable linear regression. We collected 249 measurements across 30 operations involving 24 patients through the pediatric epilepsy surgery program at UCLA Mattel Children’s Hospital. On multivariable mixed-effects regression, brain stiffness was significantly associated with the presence of MRI lesion (β = 32.3, 95%CI 16.3–48.2; p < 0.001), severity of cortical disorganization (β = 19.8, 95%CI 9.4–30.2; p = 0.001), and recent subdural grid implantation (β = 42.8, 95%CI 11.8–73.8; p = 0.009). Brain tonometry offers the potential of real-time intraoperative feedback to identify abnormal brain tissue with millimeter spatial resolution. We present the first experience with this novel intraoperative tool for the conduct of epilepsy surgery. A carefully designed prospective study is required to elucidate whether the clinical application of brain tonometry during resective procedures could guide the area of resection and improve seizure outcomes.
Predicting the need for intubation in the first 24 h after critical care admission using machine learning approaches
Authors: Siu Benjamin Ming Kit , Kwak Gloria Hyunjung , Ling Lowell , Hui Pan 
Published: December 2020

AbstractEarly and accurate prediction of the need for intubation may provide more time for preparation and increase safety margins by avoiding high risk late intubation. This study evaluates whether machine learning can predict the need for intubation within 24 h using commonly available bedside and laboratory parameters taken at critical care admission. We extracted data from 2 large critical care databases (MIMIC-III and eICU-CRD). Missing variables were imputed using autoencoder. Machine learning classifiers using logistic regression and random forest were trained using 60% of the data and tested using the remaining 40% of the data. We compared the performance of logistic regression and random forest models to predict intubation in critically ill patients. After excluding patients with limitations of therapy and missing data, we included 17,616 critically ill patients in this retrospective cohort. Within 24 h of admission, 2,292 patients required intubation, whilst 15,324 patients were not intubated. Blood gas parameters (PaO2, PaCO2, HCO3−), Glasgow Coma Score, respiratory variables (respiratory rate, SpO2), temperature, age, and oxygen therapy were used to predict intubation. Random forest had AUC 0.86 (95% CI 0.85–0.87) and logistic regression had AUC 0.77 (95% CI 0.76–0.78) for intubation prediction performance. Random forest model had sensitivity of 0.88 (95% CI 0.86–0.90) and specificity of 0.66 (95% CI 0.63–0.69), with good calibration throughout the range of intubation risks. The results showed that machine learning could predict the need for intubation in critically ill patients using commonly collected bedside clinical parameters and laboratory results. It may be used in real-time to help clinicians predict the need for intubation within 24 h of intensive care unit admission.
Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars
Authors: Edanami Naoki , Yoshiba Kunihiko , Shirakashi Mari , Ibn Belal Razi Saifullah , Yoshiba Nagako , Ohkura Naoto , Tohma Aiko , Takeuchi Ryosuke , Okiji Takashi , Noiri Yuichiro 
Published: December 2020

AbstractWhen regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81–0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60–0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13–0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15–0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig’s epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue.
New approach to determine the surface and interface thermodynamic properties of H-β-zeolite/rhodium catalysts by inverse gas chromatography at infinite dilution
Authors: Hamieh Tayssir , Ali Ahmad Ali , Roques-Carmes Thibault , Toufaily Joumana 
Published: December 2020

AbstractThe thermodynamic surface properties and Lewis acid–base constants of H-β-zeolite supported rhodium catalysts were determined by using the inverse gas chromatography technique at infinite dilution. The effect of the temperature and the rhodium percentage supported by zeolite on the acid base properties in Lewis terms of the various catalysts were studied. The dispersive component of the surface energy of Rh/H-β-zeolite was calculated by using both the Dorris and Gray method and the straight-line method. We highlighted the role of the surface areas of n-alkanes on the determination of the surface energy of catalysts. To this aim various molecular models of n-alkanes were tested, namely Kiselev, cylindrical, Van der Waals, Redlich–Kwong, geometric and spherical models. An important deviation in the values of the dispersive component of the surface energy $${\gamma }_{s}^{d}$$

γ

s

d

determined by the classical and new methods was emphasized. A non-linear dependency of $${\gamma }_{s}^{d}$$

γ

s

d

with the specific surface area of catalysts was highlighted showing a local maximum at 1%Rh. The study of RTlnVn and the specific free energy ∆Gsp(T) of n-alkanes and polar solvents adsorbed on the various catalysts revealed the important change in the acid properties of catalysts with both the temperature and the rhodium percentage. The results proved strong amphoteric behavior of all catalysts of the rhodium supported by H-β-zeolite that actively react with the amphoteric solvents (methanol, acetone, tri-CE and tetra-CE), acid (chloroform) and base (ether) molecules. It was shown that the Guttmann method generally used to determine the acid base constants KA and KD revealed some irregularities with a linear regression coefficient not very satisfactory. The accurate determination of the acid–base constants KA, KD and K of the various catalysts was obtained by applying Hamieh’s model (linear regression coefficients approaching r2 ≈ 1.000). It was proved that all acid base constants determined by this model strongly depends on the rhodium percentage and the specific surface area of the catalysts.
Modeling the effects of perisaccadic attention on gaze statistics during scene viewing
Authors: Schwetlick Lisa , Rothkegel Lars Oliver Martin , Trukenbrod Hans Arne , Engbert Ralf 
Published: December 2020

AbstractHow we perceive a visual scene depends critically on the selection of gaze positions. For this selection process, visual attention is known to play a key role in two ways. First, image-features attract visual attention, a fact that is captured well by time-independent fixation models. Second, millisecond-level attentional dynamics around the time of saccade drives our gaze from one position to the next. These two related research areas on attention are typically perceived as separate, both theoretically and experimentally. Here we link the two research areas by demonstrating that perisaccadic attentional dynamics improve predictions on scan path statistics. In a mathematical model, we integrated perisaccadic covert attention with dynamic scan path generation. Our model reproduces saccade amplitude distributions, angular statistics, intersaccadic turning angles, and their impact on fixation durations as well as inter-individual differences using Bayesian inference. Therefore, our result lend support to the relevance of perisaccadic attention to gaze statistics.
Emergent Literacy in Spanish-Speaking Children With Developmental Language Disorder: Preliminary Findings of Delays in Comprehension- and Code-Related Skills
Authors: Pratt Amy S. , Grinstead John A. , McCauley Rebecca J. 
Published: December 2020

Purpose
This exploratory study describes the emergent literacy skills of children with developmental language disorder (DLD) who speak Spanish, a language with a simple phonological structure and transparent orthography. We examine differences between children with DLD and their typically developing (TD) peers on a battery of emergent literacy measures.

Method

Participants included 15 monolingual Spanish-speaking children with DLD (who did not present with cognitive difficulties) and 15 TD controls matched for age, gender, and socioeconomic status, ranging in age from 3;10 to 6;6 (years;months;
M
age
= 4;11). All children completed a battery of comprehension-related emergent literacy tasks (narrative retell, print concept knowledge) and code-related emergent literacy tasks (beginning sound, rhyming awareness, alphabet knowledge, and name-writing ability).

Results
On average, children with DLD performed significantly worse than TD controls on a battery of comprehension- and code-related emergent literacy measures. On all code-related skills except rhyming, children with DLD were more likely than their TD peers to score “at risk.”

Conclusions
The results suggest some universality in the effect of DLD on reading development. Difficulties with emergent literacy that are widely documented in English-speaking children with DLD were similarly observed in Spanish-speaking children with DLD. Future research should explore long-term reading outcomes in Spanish for children with DLD.
Detection of H2O and OH+ in z > 3 hot dust-obscured galaxies
Authors: Stanley F. , Knudsen K. K. , Aalto S. , Fan L. , Falstad N. , Humphreys E. 
Published: December 2020

Aims. In this paper we present the detection of H2O and OH+ emission in z > 3 hot dust-obscured galaxies (Hot DOGs).
Methods. Using ALMA Band-6 observations of two Hot DOGs, we detected H2O(202 − 111) in W0149+2350, and H2O(312 − 303) and the multiplet OH+(11 − 01) in W0410−0913. These detections were serendipitous, falling within the side-bands of Band-6 observations aimed to study CO(9−8) in these Hot DOGs.
Results. We find that both sources have luminous H2O emission with line luminosities of LH2O(202 − 111) > 2.2 × 108 L⊙ and LH2O(312 − 303) = 8.7 × 108 L⊙ for W0149+2350 and W0410−0913, respectively. The H2O line profiles are similar to those seen for the neighbouring CO(9–8) line, with line widths of full width at half maximum (FWHM) ∼800−1000 km s−1. However, the H2O emission seems to be more compact than the CO(9−8). OH+(11 − 01) is detected in emission for W0410−0913, with a FWHM = 1000 km s−1 and a line luminosity of LOH+(11 − 01) = 6.92 × 108 L⊙. The ratio of the observed H2O line luminosity over the IR luminosity, for both Hot DOGs, is consistent with previously observed star-forming galaxies and active galactic nuclei (AGN). The H2O/CO line ratio of both Hot DOGs and the OH+/H2O line ratio of W0410−0913 are comparable to those of luminous AGN found in the literature.
Conclusions. The bright H2O(202 − 111), and H2O(312 − 303) emission lines are likely due to the combined high star formation levels and luminous AGN in these sources. The presence of OH+ in emission, and the agreement of the observed line ratios of the Hot DOGs with luminous AGN in the literature, would suggest that the AGN emission is dominating the radiative output of these galaxies. However, follow-up multi-transition observations are needed to better constrain the properties of these systems.
Management of Large Focal Chondral and Osteochondral Defects in the Knee
Authors: Calcei Jacob G. , Ray Taylor , Sherman Seth L. , Farr Jack 
Published: December 2020

AbstractLarge, focal articular cartilage defects of the knee (> 4 cm2) can be a source of significant morbidity and often require surgical intervention. Patient- and lesion-specific factors must be identified when evaluating a patient with an articular cartilage defect. In the management of large cartilage defects, the two classically utilized cartilage restoration procedures are osteochondral allograft (OCA) transplantation and cell therapy, or autologous chondrocyte implantation (ACI). Alternative techniques that are available or currently in clinical trials include a hyaluronan-based scaffold plus bone marrow aspirate concentrate, a third-generation autologous chondrocyte implant, and an aragonite-based scaffold. In this review, we will focus on OCA and ACI as the mainstay in management of large chondral and osteochondral defects of the knee. We will discuss the techniques and associated clinical outcomes for each, while including a brief mention of alternative treatments. Overall, cartilage restoration techniques have yielded favorable clinical outcomes and can be successfully employed to treat these challenging large focal lesions.
Surgical Leadership Training beyond the Traditional Mentorship Model
Authors: Saha Shivangi 
Published: December 2020

AbstractIn this article, I reflect on my experience of being awarded the International Resident Travel Scholarship for “Plastic Surgery the Meeting 2019.” I was the first Indian to be awarded the scholarship, and it offered me not only monetary assistance but also mentorship for future leadership positions. The award further opened doors for several future opportunities in the form of memberships in the American Society of Plastic Surgery (ASPS) committees and Resident Advisory Board of the prestigious “Plastic and Reconstructive Surgery Journal.” I believe this article will make more residents aware and utilize such opportunities for their career development.
Fabricating Flaps in the Forearm Prior to Tracheal Reconstruction
Authors: Biswas Gautam , Panchal Karnav Bharat , Jain Prateek V. , Manikantan Kapila , Sharan Rajeev , Arun Pattatheyil 
Published: December 2020

Abstract
Background The process of reconstruction of tracheal defects is complex and still not optimum. Options range from using staged reconstructions, combining flaps with autologous or alloplastic implants, as well as use of tissue-engineered constructs combined with vascularized tissues which are lined with cell cultures. Staged reconstructions using prelaminated epithelium, and prefabricated flaps, help in reconstruction of this complex structure. Prefabricating the flap at a different site allows for integration of the tissues prior to its transfer.
Method This article reports two patients planned for tracheal reconstruction for the purpose of advanced papillary carcinoma of the thyroid invading the trachea. Staged reconstruction using a prefabricated radial artery forearm flap (RAFF) and split rib cartilage was performed. In the second patient, a young girl, a similar construct of the RAFF, prelaminated with buccal mucosa, was performed. However, in the latter case, an intraoperative decision by the head and neck team to limit excision of the trachea sparing the mucosa was taken; the reconstruct in the forearm was redundant and needed to be discarded, replacing the defect with a free superficial circumflex iliac artery perforator (SCIP) flap.
Result At 3 years follow-up, both the patients are free of disease, with the construct serving its purpose in the older female.
Statistical characteristics of laser interference and its effect on IR optoelectronic observation systems
Authors: Pavlov N.I. , Rezunkov Yu.A. 
Published: December 2020

Abstract
We consider statistical characteristics of laser interference recorded in the focal region of an IR optoelectronic observation system under field and out-of-field illumination by laser radiation. The applicability of the analytical description of experimental histograms of the laser interference signal distribution at the photodetector array output using the probability density approximations in the form of gamma distribution and the Gaussian function is substantiated. It is shown that the specific form of these functions is determined both by the mean value (mathematical expectation) of the interference signal and by the characteristic parameter M, which depends on the statistical properties of the laser interference.
Pump depletion in Raman lasing in a graded index multimode fibre
Authors: Kuznetsov A.G. , Kablukov S.I. , Podivilov E.V. , Babin S.A. 
Published: December 2020

Abstract
We examine multimode diode laser pump depletion in a graded index multimode (MM) fibre Raman laser generating a high-quality Stokes beam. Spatial ‘hole burning’ in the transmitted pump beam is demonstrated. A balance model is constructed for interaction of the pump and Stokes waves in the MM Raman laser. Analytical formulas are derived and used in calculations demonstrating qualitative agreement with experimental data. The origin of the observed quantitative discrepancies is discussed.
Valuation of peers’ safe choices is associated with substance-naïveté in adolescents
Authors: Chung Dongil , Orloff Mark A. , Lauharatanahirun Nina , Chiu Pearl H. , King-Casas Brooks 
Published: December 2020

Significance
During adolescence, substance use and other health-risk behaviors emerge, particularly among those who associate with peers engaging in such behaviors and less so for adolescents with less deviant peers. Here, we provide behavioral and neural evidence for a beneficial role of safer peers, rather than a detrimental influence of risky peers, in guiding adolescents’ choices and substance use. The extent to which adolescents value peers’ safe choices predicted substance-naïveté even after controlling for other factors associated with substance use, while valuation of peers’ risky choices was unrelated to substance use. Whereas previous studies have largely examined associations between negative peers and increased health-risk behaviors, our data support a significant role of positive social peers for favorably influencing health-risk behaviors.
Periodic training of creeping solids
Authors: Hexner Daniel , Liu Andrea J. , Nagel Sidney R. 
Published: December 2020

Significance
It is well appreciated that many disordered materials deform their shape irreversibly (plastically) under an external load (e.g., memory foam). Here, we show that this plasticity can be exploited to train materials to develop novel elastic responses by straining them periodically. By applying different periodic strains to a common viscoelastic material, we are able to design a number of different responses. These include a maximally negative Poisson’s ratio, bistable behavior, and nonlocal bond-specific responses. In contrast to computer-aided design, we rely on plasticity to self-organize the system in response to local stresses. This approach shows promise to achieve an unprecedented control over behavior at large strains well beyond the linear-response regime.