bluuebunny/crossref_metadata_2025_split huggingface dataset:
High UBE2T mRNA expression and its prognostic significance in Ovarian cancer: a study based on data mining
Authors: wu zenghong 
Published: January 2020

Abstract
Objection Ovarian cancer (OC) affects approximately 22 000 women annually in the US and ranks 5th in cancer deaths, largely due to diagnosed with advanced stage1. Epithelial ovarian cancer (EOC) accounts for approximately 90% of all ovarian cancer cases. Our study was to assess the prognostic meaningful of UBE2T expression in OC dependent on data acquired from TCGA and so as to increase further knowledge into the biological pathways involved in OC pathogenesis related to UBE2T.Method Information on gene expression and comparing clinical data were recognized and downloaded from TCGA. Gene set enrichment analysis (GSEA) created an arranged list of all genes s indicated by their connection with UBE2T expression.Results The scatter plot showed the difference of UBE2T expression between normal and tumor samples (P<0.01). In order to decide the biological interaction network of UBE2T in OC, we applied to tab Network in cBioPortal and the 50 most as often altered neighbor genes of UBE2T were showed utilizing Network and the most frequent alterations were HES1. The GSEA results showed that cell cycle, DNA replication, RNA degradation, some cancers, spliceosome, Huntington’s disease, oxidative phosphorylation are differentially enriched in UBE2T high expression phenotype. Cumulative survive showed that dendritic cell of immune infiltrates statistically significant (P<0.05) of UBE2T in OC indicating that dendritic cell significantly affecting the prognosis, it is worth further research and exploration.Conclusion Our study found that the expression of UBE2T was significantly increased in OC patients and associated with several clinical features. UBE2T may be a potentially useful prognostic molecular biomarker of bad survival in OC, while further experimental ought to be performed to demonstrate the biologic effect of UBE2T.
Feasibility of Using an LED-Probe in Third-Space Endoscopy: A Clinical Study
Authors: Mondragón Oscar Victor Hernández , Mottu Raul Antonio Zamarripa , Pineda Omar Michell Solórzano , Aguilar Raul Antonio Gutierrez , Contreras Luis Fernando Garcia 
Published: January 2020

Abstract
Background and aims: Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting devices are used to prevent organic injuries. We aimed to investigate the feasibility of using a hand-made LED-probe (LP) in third-space procedures. Patients and Methods: This prospective study was conducted in a tertiary-care center in Mexico between December 2016 and January 2019. We included peroral endoscopic myotomy (POEM) and gastric peroral endoscopic myotomy(G-POEM) procedures. Pseudoachalasia, peptic ulcer, normal gastric emptying scintigraphy (GES) and prepyloric tumors were excluded. LP was used to guide or confirm procedures. Clinical and procedural characteristics were recorded and analyzed. Results: Seventy third-space procedures were included (42POEM,28G-POEM), with an average patient age of 46.7±14.3 and 43.7±10.1 years, respectively. For the POEM and G-POEM groups, respectively, 18/42(42.9%) and 13/28(46.7%) patients were males, median procedure times were 50 (interquartile range[IQR]: 38-71) and 60(IQR: 48-77) min, median LP placement times were 5(IQR: 4-6) and 6(IQR: 5-7) min, mild adverse events occurred in 4(9.4%) and 4(14.2%) of cases, and clinical success at 6 months occurred in 100% and 85.7% of cases. Integrated relaxation pressure (IRP) improved from 27.3±10.8 to 9.5±4.1 mmHg (p<0.001); retention percentage at 4 hours also improved. LP was successfully placed and confirmed adequate myotomy including 14.2% and 17.8% of POEM and G-POEM difficult patients. Conclusions: Using an LP is promising and allows guiding during third-space procedures either for submucosal tunnel creation or myotomy confirmation, with excellent safety and efficacy in clinical practice.
Association between alcohol consumption and frailty in three Chinese cities
Authors: Nie Xin , Williams Greg , Verma Arpana , Zhu Yongkai , Fu Hua , Jia Yingnan , Dai Junming , Gao Junling 
Published: January 2020

Abstract
Background: Frailty is often described as a condition of the elderly but affects all age groups, alcohol consumption is associated with frailty. The aim of this study is to examine the associations between alcohol consumption pattern (ACP) and frailty in three cities in adults. . Methods: A cross-sectional study was conducted in three cities in China from June 2017 to October 2018. In total, 20,716 residents aged ≥18 years old were selected by using a multi-level stage sampling procedure. Alcohol consumption pattern was assessed by CAGE four-item questionnaire. Frailty was measured by a validated Chinese version of the FRAIL scale. Multinomial logistic regressions were used to examine the association of ACP with pre-frailty and frailty after controlling for varied covariates. Results: In general, the prevalence of pre-frailty and frailty was 35.25% and 11.42%, respectively. After controlling for covariates and interaction of age and ACP, non-problematic drinkers neither had association with pre-frailty(OR: 1.13, 95%CI:0.97-1.31) nor with frailty(OR:0.86,95%CI:0.68-1.12), while problematic drinkers had high odd ratios of pre-frailty(OR: 1.35, 95%CI:1.06-1.72) and frailty(OR:1.52, 95%CI:1.02-2.26) compared with non-drinker. Conclusions: our study found a positive association between problematic drinking and (pre-) frailty, no relationship between non-problematic drinking and (pre-) frailty compared with non-drinking among whole Chinese population. Based on previous findings and ours, we conclude it is important for the prevention of frailty to advocate zero drinking among whole population. Keywords: alcohol consumption, frailty, life course
The association between nutritional status and household sanitation among rural children in the Tibetan and Sichuan minority areas: a cross-sectional study
Authors: Zhu Xian , Liu Chenglu , Xu Chang , Li Mingjing , Jiang Wei , Zhang Xiaofeng , Liu Yajun , Xu Hong 
Published: January 2020

Abstract
Background: To investigate the nutritional status and household sanitation among children under 5 in Tibetan and Sichuan minority areas and to analyse the association between nutritional status and household sanitation. Methods: A cross-sectional survey was conducted by the probability proportional to size sampling method between August and October 2016. Nutritional status was evaluated according to the standards of growth and development recommended by the World Health Organization. Bivariate and multivariate logistic regression analyses were used to analyse the association between nutritional status and household sanitation. Results: A total of 965 children under the age of 5 and their caregivers were included. The rates of normal development, stunting, underweight, wasting, overweight and obesity of children in Sichuan and Tibet were 69.0%, 19.8%, 8.0%, 5.2%, 4.6% and 1.8%, respectively. The multivariable logistic regression analyses shows that other unprotected water sources (AOR=3.21, 95%CI=1.41~7.32), unboiled drinking water (AOR=2.05, 95%CI=1.41~2.97), sanitary and dry toilets (AOR=2.04, 95%CI=1.12~3.71), unsanitary and dry toilets (AOR=2.80, 95%CI=1.42~5.51), usually do not washing hands at critical times (AOR=2.11, 95%CI=1.15~3.90), washing hands only with water (AOR=1.53, 95%CI=1.03~2.26) and unsanitary treatment of children's faeces (AOR=1.56, 95%CI=1.11~2.20) were the risk factors for stunting in children. Protected well water (AOR=4.28, 95%CI=1.46~12.52), other unprotected water sources (AOR=4.30, 95%CI=1.36~13.61), unsanitary and dry toilets (AOR=4.44, 95%CI=1.26~15.59), washing hands at only one critical moment (AOR=2.77, 95%CI=1.15~6.65), washing hands only with water (AOR=2.22, 95%CI=1.20~4.09) and unsanitary treatment of children’s faeces (AOR=2.01, 95%CI=1.23~3.28) were risk factors for underweight in children. Conclusion: The malnutrition of children under 5 years of age in the rural areas home to ethnic minorities in Sichuan and Tibet is serious, and the problem of stunting is particularly prominent. The children's household sanitation status is poor, and the family's economic income has an impact on household sanitation; thus, household sanitation has an impact on both the height and the weight of the child. The relevant departments should increase the family's economic income while conducting household sanitation interventions, thereby reducing the incidence and mortality due to malnutrition.
What do we know about the impact of sexual violence on health and health behaviour of women in Estonia?
Authors: Lippus Hedda , Laanpere Made , Part Kai , Ringmets Inge , Karro Helle 
Published: January 2020

Abstract
BackgroundSexual violence against women is a major public health issue and a breach of human rights. Although various consequences of sexual violence on health have been described in a large number of scientific publications, very little is known about this topic in Estonia. The aim of this study was to examine the prevalence of sexual violence and associations between exposure to sexual violence and risky health and sexual behaviours among women in Estonia.MethodsA population-based cross-sectional study was carried out in Estonia in 2014. Self-reported data regarding selected indicators of risky health and sexual behaviours were collected from 1670 women, aged 18–44 years, via a self-administered questionnaire. To measure the prevalence of sexual violence, questions from the NorVold Abuse Questionnaire were included. Chi-square and multivariate logistic regression were used to analyse the data.ResultsOf the respondents, 22.7% (n=379) reported being exposed to sexual violence during their lifetime, and over half of these women had had these experiences before the age of 18. Statistically significant associations were found between sexual violence and smoking (adjusted odds ratio (AOR) 1.32, 95% CI 1.03–1.70), alcohol consumption (AOR 1.52, 95% CI 1.18–1.95), illicit drug use (AOR 2.21, 95% CI 1.70–2.89), sexual intercourse for money or other material reward (AOR 3.51, 95% CI 1.62–7.61), concurrent sexual relationships (AOR 2.64; 95% CI 1.80–3.86), and being diagnosed with sexually transmitted infections (AOR 1.48, 95% CI 1.09–2.01).ConclusionsIn Estonia, sexual violence against women is widespread and is associated with several risky health and sexual behaviours. Efforts should be made to raise awareness regarding the prevalence and negative impact of sexual violence, both among the general public and professionals. Women who have been exposed to sexual violence are in need of professional medical, legal and psychological help free from prejudice to help them recover from such traumatic events.
Exploring potential intervention strategies to reduce unsafe youth migration in Ethiopia: A mixed methods study
Authors: Habtamu Kassahun , Minaye Abebaw , Admas Fantahun , Gebremariam Mesay , Tibebu Abera , Adigeh Yohannese , Zeleke Seleshi 
Published: January 2020

Abstract
Background Several studies investigated risk and protective factors for unsafe youth migration. However, evidence on what interventions help to reduce unsafe youth migration is lacking. This study aimed primarily to identify interventions that may help to reduce unsafe youth migration from the perspectives of key stakeholders.Methods A mixed methods study was conducted in eight migration hotspot areas in Ethiopia. For the qualitative study, in-depth interviews and focus group discussions (FGD) were used to collect data. FGDs were conducted with students, teachers and parents separately. A school principal, heads of relevant offices of the local government, a community representative and a religious leader were interviewed. Thematic analysis was used to identify the prominent issues. Quantitative data were collected from students (n=800), teachers (n= 240) and parents (n=160) who were selected using multistage sampling. We developed a structured questionnaire to collect data. Descriptive statistics, t-test and one-way analysis of variance (ANOVA) were used to analyze the data.Results We identified potential interventions to reduce unsafe youth migration and grouped them into five domains: awareness and attitudinal/behavioral changes, job opportunities and training, governmental and parental roles, improving the education system, and law enforcement and migration management. The need for cooperation among stakeholders was cross-cutting. More than 80% of the survey respondents agreed or strongly agreed in that the interventions would potentially be relevant and effective. We found significant mean difference in the degree of endorsement due to age and level of education in two of the domains of interventions (i.e. enhancing access to resources and jobs and law enforcement and managing migration). Older and more educated respondents were highly likely to endorse intervention strategies more than younger and less educated respondents. Significant mean difference was observed in one of the domains (i.e. law enforcement and managing migration) due to respondent type. Teachers and parents were more likely than students to endorse the intervention.Conclusion We identified contextually relevant intervention strategies that would potentially be effective to reduce unsafe youth migration in Ethiopia. We suggest that there is to prioritize and empirically test the effectiveness of these intervention strategies.
Comparison of the incidence of venous thromboembolism with minimally invasive total hip arthroplasty: a case control study
Authors: Nishiwaki Toru , Oya Akihito , Kanaji Arihiko 
Published: January 2020

Abstract
Background: Venous thromboembolism (VTE) remains a major complication after total hip arthroplasty (THA), irrespective of the surgical approach. This study investigated the incidence of VTE in patients undergoing THA through intermuscular minimally invasive surgical techniques, which included a direct anterior approach (DAA), an anterolateral approach (AL), and anterolateral supine approach (ALS), at a single institution. Methods: One hundred consecutive patients treated with each surgical approach were evaluated. Plasma D-dimer levels 1 month preoperatively and 1 day postoperatively, operative time, and intraoperative blood loss were recorded, and the presence of VTE was evaluated based on multidetector row computed tomography performed the day after surgery. Student’s t-test and Pearson’s chi-square test or one-way analysis of variance were used in statistical analysis. Results: No differences among the groups in terms of age, height, weight, operative time, intraoperative bleeding, and preoperative and postoperative D-dimer levels were observed. The overall incidence of VTE was 21%. The incidences of VTE were 30% in AL, 17% in ALS, and 16% in DAA, representing a significantly higher rate in AL than in ALS and DAA (P=0.025). The incidences of VTE on the operated side were 19% in AL, 13% in ALS, and 12% in DAA, with no statistically significant differences. The incidences of VTE on the non-operated side were 22% in AL, 9% in ALS, and 8% in DAA; these differences were statistically significant (P=0.0045). Conclusions: Results showed that the incidence of VTE was significantly higher in AL than in ALS and DAA, especially for the non-operated side.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway
Authors: Pang Bo , Zhang Juanjuan , Yuan Jihong , Shi Yanan , Qiao Ling 
Published: January 2020

Abstract
Background Lipid metabolism reprogramming is now accepted as a new hallmark of cancer. Hence, targeting the lipogenesis pathway may be a promising avenue for cancer treatment. Valproic acid (VPA) emerges as a promising drug for cancer therapy, however, the underlying mechanisms are not yet fully understood. This study aimed to investigate the effects and mechanism of VPA on cell viability, lipogenesis, and apoptosis in human prostate cancer PC-3 cells.Methods The effects of VPA on the viability of PC-3 cells were investigated using MTT assay and wound-healing assay. Oil Red O staining was used to examine lipid droplets, and DAPI staining assay and Annexin V-PI staining assay were used to measure the extent of cell apoptosis. Quantitative real-time PCR and Western blotting were used to determine the expression of lipogenesis and apoptosis genes. Statistical and analytical data with SPSS 17.0 Software, statistical significance was set at *P < 0.05, **P < 0.01, and ***P < 0.001 levels.Results The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 cells. Moreover, the expression of CCAAT/enhancer-binding protein α (C/EBPα), as well as sterol regulatory element-binding protein 1 (SREBP-1) and its downstream effectors, including fatty acid synthase (FASN), acetyl CoA carboxylase 1 (ACC1), and antiapoptotic B cell lymphoma 2 (Bcl-2), markedly decreased in PC-3 cells after VPA administration. Mechanistically, the overexpression of C/EBPα rescued the levels of SREBP-1, FASN, ACC1, and Bcl-2, enhanced lipid accumulation and attenuated apoptosis of VPA-treated PC-3 cells. Conversely, C/EBPα knockdown by siRNA further decreased the levels of SREBP-1, FASN, ACC1, and Bcl-2 and lipid accumulation and enhanced apoptosis. In addition, SREBP-1a and 1c enhanced the expression of FASN and ACC1, but only SREBP-1a had a signiﬁcant eﬀect on Bcl-2 expression in VPA-treated PC-3 cells.ConclusionsOn the whole, it is concluded that VPA significantly inhibits cell viability via inhibiting lipogenesis and inducing apoptosis by the C/EBPα/SREBP-1 pathway in PC-3 cells. Hence, VPA, which targets lipid metabolism and apoptosis, is a promising candidate for PCa chemotherapy.
BASIC PRINCIPLES OF ALLERGIC RHINITIS THERAPY IN PAEDIATRIC PRACTICE
Authors: BELOV V. A. 
Published: January 2020

The article introduces the main mechanisms for developing an allergic reaction, and describes the main clinical manifestations of allergic rhinitis. The basic principles of therapy are covered. Special attention is paid to the use of the Vibrocil combination drug, which contains dimethindene blocking H1-histamine receptors and phenylephrine
FEATURES OF PRESCRIBING ANTIHISTAMINES IN PEDIATRIC PRACTICE
Authors: GLUSHKOVA E. F. , SUROVENKO T. N. 
Published: January 2020

Objective of the Review: Illustrate the use of antihistamines in the treatment of allergic diseases in children.Key Points: Due to the increasing frequency of occurrence of allergic diseases in the population, including among children, the questions of approaches to therapy and the choice of effective and safe drugs acquire particular urgency. Today the usual drugs of choice are antihistamines of the second generation. Their efficacy was proven over the years, and a large amount of data ontheir use has been accumulated. They have firmly occupied their niche in the pharmacotherapy of allergic diseases. And yet antihistamines of the first generation still find their use in certain clinical situations in pediatrics.Conclusion: This article is devoted to the review of the first generation of antihistamines and their use in pediatric practice.
CHARACTERIZATION OF PSYCHOLOGICAL AND PHYSICAL DEVELOPMENT IN CHILDREN OF GESTATION DIABETES PREGNANCIES
Authors: NIKITINA I. L. , KONOPLYA I. S. , POLYANSKAYA A. A. , LISKINA A. S. , POPOVA P. V. 
Published: January 2020

The physical and neurological development of children born to mothers with gestation diabetes mellitus (GDM) is a matter of research interest. We examined 28 children whose mothers were diagnosed with GDM, in the newborn period and at 6 months. By the parameters of physical development at birth the number of children with outstripping development and the average body mass index (BMI) was predominant and by the end of the first semester of life most of the children had the values of the average parameters specified above, that is, normal for that age, range, but the proportion of the deficient BMI remained unchanged. Insulin therapy during pregnancy had no significant impact on the frequency characteristics of children with physical development disorders. The neurological disorders of the six-month-old children born of women with gestation diabetes mellitus and non-targeted metabolic control were more severely represented by sensory sphere disturbances and interaction with subjects; to a lesser extent - by emotional and voice development. The children of this group had the minimum disturbances in the development of the motor sphere.
RISK FACTORS OF JAW FOLLICULAR CYSTS DEVELOPMENT IN CHILDREN
Authors: SLESAREVA O. A. , POTEMINA T. E. 
Published: January 2020

The scientific article contains the results of the review of modern domestic and foreign literature. Risk factors data of follicular cysts of the jaws in children are generalized. Relevant points of individual risk factors, and the influence of their combination on the event of follicular cysts are reviewed. There was made a conclusion about the absence of the chief, leader factor, whichconduces the evolution of follicular cysts. The necessity of further study of multifactorial pathogenesis. This will help to develop identifying criteria of persons with risk for the evolution of follicular cysts of the jaws, the necessity and the principles of prevention and screening for early detection of abnormalities are pointed
NEWBORN SKIN CARE
Authors: RYUMINA I. I. , ZUBKOV V. V. 
Published: January 2020

In this article the authors provide a detailed description of anatomic and physicological peculiarities of the newborn children, the role of the vernix caseosa, a group of premature children is described as a separate group. Examples of skin pathology development risk factors, ways to prevent them and first aid measures are provided
ANTITUSSIVE DRUGS IN CHILDREN’S PRACTICE
Authors: KOLOSOVA N. G. , SHATALINA S. I. 
Published: January 2020

Adequate choice and use of antitussive therapy in pediatrics presupposes knowing at least the two key aspects: causes of cough and the specific mechanism of the cough reflex in children, as well as the mechanisms of action of antitussive drugs used. The need for the treatment of cough as such, that is, prescription of the so-called antitussive drugs, arises mainly in children with nonproductive, dry, persistent cough. Central antitussives suppress the function of the cough center in the medulla oblongata or other associated nerve centers of the brain. The antitussive drug butamirate, often used in children, selectively affects the cough center, does not cause respiratory depression, has an extremely low incidence of side effects, remains effective in prolonged therapy, and starts to exert its maximum effect after the first application