bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time health monitoring through urine metabolomics
Authors: Miller Ian J. , Peters Sean R. , Overmyer Katherine A. , Paulson Brett R. , Westphall Michael S. , Coon Joshua J. 
Published: November 2019

AbstractCurrent healthcare practices are reactive and based on limited physiological information collected months or years apart. By enabling patients and healthy consumers access to continuous measurements of health, wearable devices and digital medicine stand to realize highly personalized and preventative care. However, most current digital technologies provide information on a limited set of physiological traits, such as heart rate and step count, which alone offer little insight into the etiology of most diseases. Here we propose to integrate data from biohealth smartphone applications with continuous metabolic phenotypes derived from urine metabolites. This combination of molecular phenotypes with quantitative measurements of lifestyle reflect the biological consequences of human behavior in real time. We present data from an observational study involving two healthy subjects and discuss the challenges, opportunities, and implications of integrating this new layer of physiological information into digital medicine. Though our dataset is limited to two subjects, our analysis (also available through an interactive web-based visualization tool) provides an initial framework to monitor lifestyle factors, such as nutrition, drug metabolism, exercise, and sleep using urine metabolites.
Tailoring of multi-pulse dynamics in mode-locked laser via optoacoustic manipulation of quasi-continuous-wave background
Authors: Lee Ki Sang , Ha Chang Kyun , Moon Kyoung Jun , Han Dae Seok , Kang Myeong Soo 
Published: November 2019

AbstractVarious nonequilibrium multi-pulse states can emerge in a mode-locked laser through interactions between the quasi-continuous-wave background (qCWB) and pulses inside the laser cavity. While they have been regarded as unpredictable and hardly controllable due to the noise-like nature of qCWB, we here demonstrate that the qCWB landscape can be manipulated via optoacoustically mediated pulse-to-qCWB interactions, which alters the behaviors of multi-pulse dynamics. In this process, impulsive qCWB modulations are created at well-defined temporal locations, which act as the point emitters and attractive potentials for drifting pulse bunches and soliton rains. Hence, we can transport a single pulse bunch from a certain temporal position to another, and also make soliton rains created and collided exclusively at specific temporal locations. Our study opens up possibilities to control the nonequilibrium multi-pulse phenomena precisely in the time domain, which would offer a practical means of advanced optical information processing.
Failure of cost-benefit analysis in gastrointestinal endoscopy
Authors: Sonnenberg Amnon , Bakis Gennadiy 
Published: November 2019

Abstract
Background and study aims We discuss the occurrence of two cases, where the endoscopic pursuit of diagnostic certainty resulted in adverse events that exceeded the clinical relevance of the endoscopic diagnosis itself. In both instances, physicians were hesitant to subject their patients to a necessary surgical intervention before gastrointestinal endoscopy had provided them with absolute assurance that no other mitigating factors could possibly jeopardize the success of a planned intervention. In trying to avoid a single and potentially bad outcome of a necessary medical intervention, the physicians exposed their patients to many more additional and unnecessary risks. As key players in clinical decision-making, physicians sometimes may find it difficult to disentangle their own risk-benefit considerations from those of their patients.
Friedrich Theodor von Frerichs (1819–1885): Wegbereiter der klinischen Diabetologie
Authors: Schmechel Harald , Fünfstück Reinhard 
Published: November 2019

ZusammenfassungProf. Friedrich Theodor von Frerichs (1819–1885) war ein international hoch geachteter Kliniker an der Berliner Charité und im Jahr 1882 Gründer der heutigen Gesellschaft für Innere Medizin. Sein 200. Geburtstag am 24. März 2019 war Anlass, seine medizinisch-wissenschaftlichen Leistungen zu würdigen.Friedrich Theodor von Frerichs gilt als Begründer der wissenschaftlich fundierten Medizin. Er führte naturwissenschaftliche Methoden in die Diagnostik und Ursachenforschung von Erkrankungen ein. Von Frerichs wurde frühzeitig bekannt durch die zwei Monografien „Über die Leberkrankheiten“ und „Brightsche Nierenkrankheit“. Er wird als Begründer der modernen Hepatologie angesehen.Von gleicher Bedeutung für die Entwicklung der Diabetologie ist das ein Jahr vor seinem Tod 1884 erschienene Werk „Über die Zuckerkrankheit“. In diesem Buch fasste er seine in 40 Berufsjahren an über 400 selbst behandelten Patienten gesammelten klinischen Erfahrungen zur Zuckerkrankheit zusammen. Gleichzeitig beschrieb er die von ihm bei über 50 durchgeführten Autopsien festgestellten Organveränderungen bei Diabetes mellitus. Die systematische vergleichende Aufarbeitung jedes Einzelfalls im Querschnitt- wie Längsschnittverhalten führte ihn in der Vorinsulinära zu Erkenntnissen, die auch heute zu den Grundlagen der modernen Diabetologie gehören. Der methodische Ansatz der vergleichenden kasuistischen Bewertung von Frerichs zeigt uns die Bedeutung der klinischen Forschung für die spezifische Entwicklung eines Fachgebiets. Er kann daher zu Recht als Wegbereiter der klinischen Diabetologie bezeichnet werden.Das Ziel der Arbeit ist es, die Verdienste von Friedrich Theodor von Frerichs für die Entwicklung der klinischen Diabetologie in der Vorinsulinära zu zeigen.
Review of Prediabetes and Hypertensive Disorders of Pregnancy
Authors: Carris Nicholas W. , Nwabuobi Chinedu K. , He Weiwei , Bullers Krystal , Wilson Roneé E. , Louis Judette M. , Magness Ronald R. 
Published: November 2019

AbstractObesity and diabetes increase hypertensive disorders of pregnancy (HDP) risk, thus preventive interventions are heavily studied. How pregestational prediabetes and related interventions impact HDP risk is less characterized. Therefore, we searched and reviewed the literature to assess the impact on HDP risk of prediabetes and varied interventions. We identified 297 citations related to pregnancy, prediabetes, and early pregnancy interventions. We also reviewed the references and citations of included articles. We included five studies assessing HDP outcomes in women with first trimester hemoglobin A1c in the prediabetes range (5.7–6.4%). One prospective observational study demonstrated first trimester hemoglobin A1c (5.9–6.4%) is associated with increased HDP risk, while another prospective observational study and one retrospective observational study had similar trends without statistical significance. A small and underpowered randomized controlled trial demonstrated initiating gestational diabetes mellitus treatment (i.e., diet, monitoring, ± insulin) in response to first trimester hemoglobin A1c (5.7–6.4%) did not statistically reduce HDP compared with standard care. One retrospective observational study suggested metformin, when started early, may reduce HDP risk in patients with prediabetes. Pregestational prediabetes appears to increase HDP risk. Interventions (i.e., metformin, diet/glucose monitoring, and/or exercise) to reduce HDP risk require additional study with long-term follow-up.
CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells
Authors: Montalto Angela Simona , Currò Monica , Russo Tiziana , Ferlazzo Nadia , Caccamo Daniela , Ientile Riccardo , Romeo Carmelo , Impellizzeri Pietro 
Published: November 2019

Abstract
Introduction CO2 pneumoperitoneum can influence the biological behavior of neuroblastoma (NB). Angiogenesis and genetic features are responsible for malignant phenotype of this tumor. We examined the CO2 effects on N-Myc, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2) expression as critical biomarkers of tumor invasiveness, in NB cells without N-Myc amplification.
Materials and Methods SH-SY5Y cells were exposed to CO2 (100%) at 15 mm Hg pressure for 4 hours and then moved to normal condition for 24 hours. Control cells were incubated with 5% CO2 for the same time. In control and CO2-exposed cells, the messenger ribonucleic acid (mRNA) levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, VEGF-A, and MMP-2 were quantified by real-time polymerase chain reaction. N-Myc expression was evaluated by Western blot analysis.
Results The exposure to 15 mm Hg CO2 (100%) for 4 hours induced an increase in HIF-1α, but not in HIF-2α, mRNA levels. No differences were observed in N-Myc expression between exposed and control cells at each incubation time. Similarly, no significant differences were found for VEGF-A and MMP-2 transcript levels. In CO2 exposed cells, we observed only a slight increase in both VEGF-A and MMP-2 mRNA levels after 4 and 24 hours in comparison to controls.
Conclusion In our study, the hypoxic environment induced by CO2 exposure does not affect the expression of critical biomarkers of NB aggressiveness, such as N-Myc, VEGF, and MMP-2, in human SH-SY5Y NB cells without N-Myc amplification. These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to evaluate these effects in others in vitro and in vivo models.
Failure to Thrive, Jaundice, and Polyuria in Early Infancy: Common Presentation with an Uncommon Lethal Etiology
Authors: Sharma Sonia 
Published: November 2019

AbstractA 5-month-old female infant from a consanguineous Indian Muslim family presented with polyuria, polydipsia, failure to thrive, impaired renal function, and neonatal hepatitis of unknown cause at 1 month of age. Clinical exome testing revealed renal–hepatic–pancreatic dysplasia caused by homozygous c. 1985 + 5G > A pathogenic variations in NPHP3. Our case illustrates delay in confirmatory diagnosis of such rare disorders in our region due to the lack of suspicion and unawareness of the availability of genetic testing even when there are no cost constraints.
Affective urbanism: towards inclusive design praxis
Authors: Viderman Tihomir , Knierbein Sabine 
Published: November 2019

AbstractThis paper conceptualizes affective urbanism as both research framework and praxis, engaging professionals and concerned publics alike in the insurgent making of cities. With its focus on affect and bodily encounters, it taps into the rich knowledge of practices of improvising and inventing in everyday life, which tend to fall outside the realm of discursive and visual representations. An analysis of spatial practices of the collectivePlataforma de Afectados Por La Hipotecain Barcelona illustrates how a mobilization of affects fosters not only individual, but first and foremost a collective capacity to negotiate belonging, appropriate space and contest alienated conditions of everyday life. The argument rests on the hypothesis that affect implicates the ethical engagement with people at places of everyday life, thus producing a medium and means for transgressing socio-spatial divides and challenging practices of exclusion, othering and dispossession. The value of this kind of work does not necessarily lie in the quality of conceived or materialized design, but rather in enacting an inclusive and empathic design praxis which connects to people’s multiple lived spaces and cultivates lived space of deep and caring social relations.
Holistic assessment of consecutive interpretation
Authors: Lee Sang-Bin 
Published: November 2019

Abstract
The article aims to show how interpreter trainers holistically grade student performances. For this purpose,
experimental rating sessions were held for four undergraduate interpreter trainers. The raters were asked to think aloud their
quality judgments while holistically assessing six recordings of consecutive interpretation. Their concurrent verbal reports,
along with reflective reports, interview transcripts, and video recordings of computer screen activity, were collected and
analysed in detail. Findings revealed various facets of interpreting performance assessment, including what procedures the raters
followed, what aspects of the performance they focused on, what criteria they depended on for their judgment decisions, and why
two ratings of the same performance were divergent. This article also presents a tentative model for holistic rating of
consecutive interpretation.
The doubling of design in Walter Nash’s Rhetoric
Authors: Stacey David E. 
Published: November 2019

Abstract
This chapter takes as its point of departure a simple diagram
which appears at the beginning of Walter Nash’s (1989) Rhetoric: The Wit of
Persuasion. As argued, this diagram offers a key to
understanding Nash’s unique conception of classical, renaissance and modern
rhetoric. Focusing upon the rhetorical canon of
taxis/disposition, or arrangement, the chapter explores
how Nash celebrates the skill of writers of canonical literary texts, and of
canny speakers in everyday situations, to design powerful schemes of
persuasion. It is suggested that listeners and readers appreciate the aesthetic
realization of language designed to persuade. The author observes how Nash’s
approach is to encourage receivers of language actively to take power in
rhetorical situations by parodying and rewriting, in order to critically
understand and creatively revise these schemes of persuasion. These
observations are complemented by an analysis of a press conference held by US President Donald Trump’s first press secretary, Sean Spicer.
Common Language
Authors: Carter Ronald 
Published: November 2019

Abstract
This chapter takes further debates concerning the nature of
literary language and the presence of literariness in a range of discourses
by exploring the extent to which everyday conversational discourse displays
literary properties. The author argues that studies of literary discourse,
and of the continuities between literary and non-literary discourse, have
tended to focus on written language or on representations of spoken
discourse in fictional or dramatic dialogues. This emphasis has made for
questionable connections between literature, literacy and the written
language because it assumes that spoken language is no more than a less
patterned version of written language. Using the Cambridge and Nottingham
Corpus of Discourse in English (CANCODE), the author shows how verbal
inventiveness is pervasive in ordinary talk. The chapter concludes that
common, everyday language is far from being either everyday or
common – on the contrary, it is pervasively “poetic”.
Morphological sensitivity generalizes across modalities
Authors: Gafni Chen , Yablonski Maya , Ben-Shachar Michal 
Published: November 2019

Abstract
A growing body of psycholinguistic research suggests that visual and auditory word recognition involve
morphological decomposition: Individual morphemes are extracted and lexically accessed when participants are presented with
multi-morphemic stimuli. This view is supported by the Morpheme Interference Effect (MIE), where responses to pseudowords that
contain real morphemes are slower and less accurate than responses to pseudowords that contain invented morphemes. The MIE was
previously demonstrated primarily for visually presented stimuli. Here, we examine whether individuals’ sensitivity to
morphological structure generalizes across modalities. Participants performed a lexical decision task on visually and auditorily
presented Hebrew stimuli, including pseudowords derived from real or invented roots. The results show robust MIEs in both
modalities. We further show that visual MIE is consistently stronger than auditory MIE, both at the group level and at the
individual level. Finally, the data show a significant correlation between visual and auditory MIEs at the individual level. These
findings suggest that the MIE reflects a general sensitivity to morphological structure, which varies considerably across
individuals, but is largely consistent across modalities within individuals. Thus, we propose that the MIE captures an important
aspect of language processing, rather than a property specific to visual word recognition.
Inter-layer modified

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-wave superconductivity in an effectively doped spin-1 ladder
Authors: Hou Jie , Lee Ting-Kuo , Guo Yaowu , Lou Jie , Chen Yan 
Published: November 2019

Abstract
We construct a four-leg spin-1/2 t–J type model to simulate a doped two-leg spin-1 antiferromagnetic Heisenberg ladder. Employing renormalized mean-field theory with simple Gutzwiller factors, we obtain three degenerate superconducting states with different pairing symmetry. Through improving the Gutzwiller factors, we find that the state C with inter-layer modified

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-wave pairing has the lowest energy in a large doping range. Besides, we use the density matrix renormalization group method to solve the model. The negative binding energy reveals the pairing tendency, and the pair–pair correlation functions exhibit a slowly decaying behavior on certain types of bonds. From the pair correlations, we confirm the inter-layer modified

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-wave superconducting state as the ground state of the model.
The Optimization of the Vocational School Teacher Candidates’ Employability Skills
Authors: Hadromi  , Sudarman  , Yudiono Heri , Budiman FebrianArief 
Published: November 2019

Abstract
The qualified teacher candidate of vocational schools (SMK) can be defined as individuals who have met the demands of Vocational Schools and the industry, such as mastering the hard skills and employability skills. Employability skills are the basic skills of every worker in adapting to the workplace. The purpose of this study is to describe the employability skills which must be trained to the candidates of the vocational school teacher. The results of the study showed the description of the employability skills which must be trained to the candidates of the vocational school teacher including : 1) basic skills: communication skills, information management skills, problem solving skills; 2) self-management skills: skills to demonstrate positive attitudes and behavior, responsible skills, adaptive skills, continuous learning skills, working skills; and 3) team work skills: collaborating skills, skills to participate in a project or task.
Implementation of the Navigator on Project Work Learning Model to Improve the Competence of CNC Machining Practices
Authors: Widarto  , Wijanarka B S , Nuryanto A 
Published: November 2019

Abstract
This study was aimed to explain the implementation process of the Navigator on Project Work (NOPW) learning model and to measure its effectiveness in improving the learning outcomes of the CNC Machining course. The method used in this study was classroom action research (CAR). The subject of this study consisted of ten students from the Master’s Program of Mechanical Engineering Education, Post Graduate School, UNY in the academic year of 2017. The research design included four stages, namely planning, action, observation, and reflection. The findings revealed that: (1) The implementation of the NOPW learning model worked effectively according to the formulated syntax. To obtain optimal results, the implementation of NOPW required 4 to 5 cycles; (2) The NOPW learning model was effective in improving learning achievement or CNC machining competencies. This was indicated by the increase in the mean score of students’ achievement (competency), i.e. the learning achievement in the first cycle, the second cycle, the third cycle, the fourth cycle, and the fifth cycle were 77, 44, 48, 83, and 100 respectively.
Implementation of 5-R Industrial Culture in Workshop Motorcycle Business Technique in Vocational Schools
Authors: Hartantyadhi Pratama Arga , Munadi Sudji 
Published: November 2019

Abstract
The purpose of this study was to find out the implementation of 5-R industrial culture in TBSM workshop of SMK Negeri 1 Bendo Magetan based on Ringkas, Rapi, Resik Rawat and Rajin. This study uses a qualitative approach. The process of collecting data uses interviews, documentation, and observation. The data analysis technique used in this study is data reduction, data display, and conclusion. To check the validity of the data is done by reobserving and triangulating. The object of this research is TBSM workshop of SMK Negeri 1 Bendo Magetan, Head of Automotive Department, Head of TBSM Division, Head of Workshop, Toolman, Productive Teachers and Students of SMK 1 Bendo Magetan. The results showed that the implementation of an industrial culture in a 5-R based workshop (Ringkas, Rapi, Resik, Rawat, Rajin) at the TBSM workshop at SMK Negeri 1 Bendo Magetan had gone well.
The Readiness of Automotive Workshop And Laboratory in Vocational Education High School in Facing 4.0 Industrial Era
Authors: Pangestu Fuadillah , Sukardi  
Published: November 2019

Abstract
This Research is aimed at describing the readiness of Automotive Workshop and Laboratory on SMK N 2 Luwuk in facing 4.0 Industrial Era. This research employed discrepancy model. The data in this research was obtained from interview, observation and descriptively analyzed. The readiness of automotive workshop and laboratory in facing 4.0 industrial era is measured from the standard in designing proper and convenience workshop and laboratory in vocational high school by Direktorat Pembinaan SMK. The aspects are teh work area, human resource ande the resource of facilities and infrastructure fulfilment.
The Use Of Compact Crucible Furnace For Alumunium Casting Practice At Vocational High School SMK Muhammadiyah 1 Playen
Authors: Arga Aprillyas Dovie , Tiwan  
Published: November 2019

Abstract
This study aims to examine the use of compact crucible furnace for the metal casting practice as a part of the Mechanical Technology subject at vocational high school SMK Muhammadiyah 1 Playen. The research method used was quasi experiment with nonequivalent control group design. The research population was all of the Grade 10 students in the Machining Engineering study program at SMK Muhammadiyah 1 Playen, with a total of 115 students. Class X MB, which consisted of 33 students, was picked as the experiment group, while Class X MC, with 36 students, was picked as the control group. Once the data were collected through observation and tests, the test scores were then analyzed with a difference test. The findings suggest that the scores of both the experiment and control groups increase with a gap of 51% and 25.89%, respectively. The mean score of the experiment group is 78.08, while that of the treatment group is 68.18. In conclusion, the experiment group has a higher score increase gap with 25.11% compared to the control group.
Implementing Microcontroller-Based Straight Motion Practicum Media For Improving Scientific Processing Skills
Authors: Istiantara D.T. , Mafudi I. , Handhika J. , Huriawati F. , Astutik S.W. , Rachman N.F. 
Published: November 2019

Abstract
The study is conducted in order to identify the influence of microcontroller-based straight motion practicum media on the students’ scientific processing skills. The study is a quasi-experimental research using non-equivalent control group. Then, when the study was conducted the population that had been involved was 24 students of Grade KR 1 Negeri 1 State Vocational High School Wonoasri as the control group and 30 students of Grade X IL 1 Negeri 1 State Vocational High School Wonoasri and 27 students of Grade X TPMI GulaRajawali Vocational High School Madiun as the experimental groups. The data gathering technique that had been implemented was written test on scientific processing skills with the following indicators: observing, hypothesizing, experiment designing, concluding and communicating. The results of the study show that in the control group the N-gain was 0.3 with “Moderate” category. On the contrary, in the experimental groups the implementation of microcontroller-based straight motion practicum media has influenced the improvement of the students’ scientific processing skills; for the experimental groups, the N-gain is 0.6 with “Moderate” category.