bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia
Authors: Kong Jindan , Wan Shan , Shi Sensen , Cui Songchao , Zong Xiangping , Wang Jun , Jin Jun , Zhu Mo , Zou Di , Wu Depei , Fu Jianhong 
Published: December 2020

Abstract
Objectives
This study aimed to explore useful clinical indexes for management of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia by comparing hematological and radiological characteristics between them.
Methods
Severe/critically ill patients with confirmed diagnosis of COVID-19, Influenza A H7N9 and H1N1 pneumonia were retrospectively enrolled. The demographic data, clinical manifestations, hematological parameters, and radiological characteristics of three groups were compared. The influenza A was divided into two groups with/without patient death.
Results
In this study, 16 cases of COVID-19, 10 cases of influenza A (H7N9), and 13 cases of influenza A (H1N1) who met severe/critically ill criteria were included. Compared with COVID-19, the Influenza A (H7N9 and H1N1) groups had relatively more chronic diseases (80% and 92.3% vs 25%, P༜0.05), higher APACHE Ⅱ scores (16.00 ± 8.63 and 15.08 ± 6.24, vs 5.50 ± 2.58, P༜0.05) and higher mortality rates (40% and 46.2% vs 0%, P༜0.05). The hematological finding indicated that Influenza A H7N9 and H1N1 patients had more significant lymphocytopenia (0.59 ± 0.31 × 109/L and 0.56 ± 0.35 × 109/L vs 0.97 ± 0.33 × 109/L, P < 0.05), elevated neutrophil to lymphocyte ratio (NLR; 14.67 ± 6.10 and 14.64 ± 10.36 vs 6.29 ± 3.72, P < 0.05) compared to COVID-19. Especially in influenza A patients, NLR was significant different between the patients with or without death. Compared with the H7N9 group, ground glass opacity (GGO) on chest CT was more common in the COVID-19 group (P = 0.028), while pleural effusion was relatively rare (P = 0.001).
Conclusion
Compared to COVID-19, patients with Influenza A (H7N9 and H1N1) had more underlying chronic diseases and higher mortality rates. The NLR can be used as a clinical parameter for the predication of risk stratification and outcome in COVID-19 and Influenza A pneumonia. Manifestations of pleural effusion or GGO in chest CT may be helpful for the identification of different viral pneumonia.
Maternal and Fetal Metabonomic Alterations in Maternal Lipopolysaccharide Exposure-induced Male Offspring Glucose Metabolism Disorders
Authors: Qing Qiting , Huang Lili , Zhao Mei 
Published: December 2020

Abstract
Maternal lipopolysaccharide(LPS)exposure during pregnancy induced metabolic abnormalities in male offspring, but the underlying mechanisms are still unclear. The aims of this study were to elucidate the underlying etiologies by characterizing the metabolic alterations in maternal serum and male fetal liver. Pregnant mice were intraperitoneally injected with LPS (50ug/kg/d) from gestational period (GD 15 to GD 17). In the GD18, maternal serum and male fetal liver were collected. The metabolic profiles were analyzed using liquid Chromatograph Mass Spectrometer (LC-MS) techniques. After LPS exposure, glycerophospholipids containing saturated fatty acids were up-regulated, and glycerophospholipids containing polyunsaturated fatty acids were down-regulated in both pregnant mice and male offspring. In addition, we observed that LPS-exposed dams also had increased saturated fatty acids levels and decreased polyunsaturated fatty acids levels. Because these abnormal glycerophospholipids and fatty acid metabolism have been identified as possibly associated with the risk of type 2 diabetes, our study has therefore identified two pathways (glycerophospholipids and fatty acid metabolism) that potentially underlie LPS induced fetal metabolic disease.
Comparison of three treatment methods for simple bone cyst in children
Authors: Zhang Ke Xue , Chai Wei , Zhao Jia Jia , Deng Jun Hao , Peng Zhan , Chen Ji Ying 
Published: December 2020

Abstract
Background Unicameral bone cyst (UBC) is a benign tumor whose clinical treatments and efficacy are controversial. The purpose of this study was to evaluate the efficacy of the elastic stable intramedullary nail (ESIN), the injection of autologous bone marrow (ABM) and the combination of ESIN and ABM in the treatment of simple bone cyst of children. Methods 83 children with simple bone cyst were analyzed retrospectively. 28 cases were treated with ABM. 28 cases were treated with ESIN. 27 cases were treated with ABM and ESIN. All cases were diagnosed through X-ray, CT or MRI scans. For the suspicious ones, pathological biopsy was performed for an accurate diagnosis. X-ray examinations were carried out for the postoperative follow-up. Capanna criteria for bone cyst was used for the postoperative evaluation of the three methods. Results All the cases accomplished the follow-up. The effective rate of ABM+ESIN group was significantly higher than that of the ABM group (P<0.05), and the cure rates of ESIN group and ABM+ESIN group were higher than that of ABM group (P<0.05, respectively). The cure time in ESIN group was lower than that of the other two groups (P<0.05, respectively). The times for admission were 2.0±0.0 in ESIN group, 5.7±1.9 in ABM group and 4.7±2.4 in ABM+ESIN group (P<0.05 when compared with each other). Conclusions The method of ABM combined with ESIN for children bone cyst has the highest effective and curative rates. For individual method, ESIN has a higher effective rate and curative rate than that of ABM. Meanwhile, it has the fewest hospitalizations.
Associations of Oral Health-Related Quality of Life with Age, Oral Status, and Oral Function among Psychiatric Inpatients in Japan: a cross-sectional study
Authors: Haresaku Satoru , Nakashima Fuyuko , Hara Yayoi , Kuroki Madoka , Aoki Hisae , kubota Keiko , Naito Toru 
Published: December 2020

Abstract
Background As the general population of Japan ages, the population of hospitalized psychiatric patients is also ageing. The purpose of this study was to investigate the associations of oral health-related quality of life (OHRQoL) with age and oral health, including oral and swallowing function, among psychiatric inpatients. Methods The subjects included 165 psychiatric inpatients in psychiatric hospitals in Japan. The General Oral Health Assessment Index (GOHAI) and the Eating Assessment Tool (EAT-10) were included in the questionnaire survey for the measurement of OHRQoL and the screening of dysphagia. A score ≥3 on the EAT-10 was defined as suspected dysphagia. Oral examinations and oral diadochokinesis (ODK) measurements for the tongue-lip motor function evaluation were conducted. The inpatients with acute psychiatric symptoms, moderate and severe dementia, and cognitive impairment that affected their ability to communicate and relate their feelings were excluded. A chi-squared test, the Mann-Whitney U test, and linear regression analysis were used for the analysis. The data were analysed at the 5% significance level. Results A total of 100 (64.5%) psychiatric inpatients (mean age, 67.3 [SD, 14.5] years, 49% males, and 51% females) participated in this study. The means±SDs for the decayed missing filled teeth (DMFT) index and GOHAI score were 20.6±6 and 49.7±7.9, respectively. The GOHAI score in the older age group (≥65 years) was significantly lower than that in the younger age group (<65 years). The mean ODK scores were less than 3 times/sec for all syllables. The percentage of the participants with suspected dysphagia was 45.0%. Tooth loss and suspected dysphagia were significantly associated with low GOHAI scores. The EAT-10 score was significantly correlated with the GOHAI score only after adjusting for age and sex (β=-0.725, 95% CI:-0.97, -0.64). Conclusions In hospitalized psychiatric patients, impaired oral health in the older subjects was more pronounced compared with that among general adults. Tooth loss and swallowing function were associated with OHRQoL. Therefore, oral care for the recovery of occlusal and swallowing functions may be needed to improve OHRQoL among psychiatric patients.
Carbon And Nitrogen Metabolism of Young Plants of Ucuúba (Virola surinamensis) in the Presence Of Cadmium
Authors: Viana Waldemar , Neto Cândido Oliveira , Filho Benedito , Cruz Eniel , Amarante Cristine , Fonseca Vinicius , Nogueira Glauco , Nascimento Vitor , Sousa Diana , Teixeira Jessica 
Published: December 2020

Abstract
Virola surinamensis is a forest species widely distributed in the estuaries of the Amazon. These ecosystems are susceptible to contamination by Cadmium (Cd), indicating that the plant has strategies for tolerating this metal. This study aimed to assess the nitrogen and carbon metabolism of young plants of Ucuúba (Virola surinamensis) in the presence of cadmium with the perspective of the phytoremediation of contaminated environments. The experimental design was completely randomized with five Cd concentrations (0, 15, 30, 45, and 60 mg L−1) for 60 days. In general, Cd did not affect nitrate concentration in the root but had a positive effect on leaves. The reduction of nitrate reductase (NR) in plants exposed to Cd was followed by a decrease in ammonia, total soluble amino acids (TSA), and total soluble proteins (TSP). Cd promoted an increase in total soluble carbohydrates (TSC), proline, sucrose, and reducing sugars in the plants. The increase in TSC, sucrose and proline suggests a metabolic regulatory mechanism of V. surinamensis against Cd stress.
Genome-Wide Identification and Functional Characterization of the PheE2F/DP Gene Family in Moso Bamboo
Authors: Li Long , Shi Qianqian , Li Zhouqi , Gao Jian 
Published: December 2020

Abstract
Background E2F/DP proteins have been shown to regulate genes implicated in cell cycle control and DNA repair. However, to date, research into the potential role of the Moso bamboo E2F/DP family has been limited.Results Here, we identified 23 E2F/DPs in the Moso bamboo genome, including nine E2F genes, six DP genes, eight DEL genes and one gene with a partial E2F domain. An estimation of the divergence time of the paralogous gene pairs suggested that the E2F/DP family expansion primarily occurred through a whole-genome duplication event. A regulatory element and coexpression network analysis indicated that E2F/DP regulated the expression of cell cycle-related genes. A yeast two-hybrid assay and expression analysis based on transcriptome data and in situ hybridization indicated that the PheE2F-PheDP complex played important roles in winter Moso bamboo shoot growth. The qRT-PCR results showed that the PheE2F/DPs exhibited diverse expression patterns in response to drought and salt treatment and diurnal cycles. Conclusion Our findings provide novel insights into the Moso bamboo E2F/DP family and partial experimental evidence for further functional verification of the PheE2F/DPs.
Palliative Care Needs among Patients with Advanced Illnesses in Bhutan
Authors: Laabar Tara Devi , Saunders Christobel , Auret Kirsten , Johnson Claire E 
Published: December 2020

Abstract
Background: Palliative care improves the quality of lives of patients and families affected by advanced illnesses through the prevention and relief of suffering. While palliative care is well established in developed countries, it is inadequate or non-existent in most developing countries. Palliative care is an emerging concept in Bhutan, a tiny Himalayan Kingdom. A small community palliative care service is available in the national referral hospital with three dedicated inpatient palliative care beds. This study explored the needs for palliative care among patients diagnosed with advanced illnesses and is a component of a larger project aimed to inform a suitable palliative care model for the country. Methods: This is a cross-sectional descriptive study. A survey, using a structured questionnaire including the EORTC QLQ-C30, was carried out among patients with advanced illness in hospitals, primary care units and communities across the country. Purposeful and snowball sampling strategies were used to recruit study participants. Results: Seventy (76%), out of 93 eligible patients, agreed to participate in the survey. Participants reported low to moderate scores on physical, role, emotional, cognitive and social functioning, a moderate score for the global health/ quality of life scale and moderately high (worse) scores in symptoms including fatigue, pain, insomnia, loss of appetite and the financial impact from the disease. Conclusions: The symptom burden experienced by patients affected by advanced illnesses demonstrates the need for palliative care in Bhutan. These findings will help inform the development of a public health-focused palliative care model, modified to the Bhutanese context, as recommended by the World Health Organization.
A phylogenetic framework for the bumblebee species of the subgenus Bombus sensu stricto based on mitochondrial DNA markers, with a short description of the neglected taxon B. minshanicola Bischoff, 1936 n. status. (Hymenoptera: Apidae: Bombus).
Authors: Bertsch Andreas 
Published: December 2020

Königinnen von 12 Taxa der Untergattung Bombus sensu stricto (Bombus affinis, B. albocinctus, B. cryptarum, B. lucorum, B. magnus, B. moderatus, B. occidentalis, B. patagiatus, B. sporadicus, B. terrestris, B. terricola and B. tunicatus) wurden im Frühjahr gefangen, um künstliche Kolonien zu züchten. Zusätzlich wurden Männchen von B. franklini und B. lucorum/China gefangen. Mitochondriale Cytochrome Oxidase Untereinheit I (COI) von 53 Proben wurde sequenziert (Teilsequenzen der Länge 1257 bp). GenBank Sequenzen der Ostasiatischen Arten B. hypocrita, B. ignitus und B. lucorum/China wurden einbezogen. Der Unterschied zwischen den Arten beträgt 30 – 92 Basen-Substitutionen und die Tamura-Nei genetische Distanz 0.030-0.103, während der Unterschied innerhalb der Arten nur 1 – 3 Basensubstitution beträgt und die Tamura-Nei genetische Distanz nur 0.001-0.003. Dreizehn Taxa mit Artrang sowie eine neue Art B. minshanicola Bischoff 1936 (= B. terrestris ssp. minshanicola = B. lucorum/China) wurden nachgewiesen. In der Topologie des phylogenetischen Stammbaums gibt es 4 Cluster: ein Artenpaar B. sporadicus – B. ignitus und ein Artenpaar B. terricola – B. occidentalis, ein Cluster für B. magnus, B. patagiatus and B. cryptarum mit den Subspecies B. cryptarum albocinctus und B. cryptarum moderatus sowie ein Cluster für B. hypocrita, B. lucorum, B. minshanicola, B. franklini and B. affinis. Die Arten B. terrestris mit den Subspecies B. terrestris canariensis und B. terrestris sassaricus sowie B. tunicatus sind einzeln abgetrennt. Da sich im Alignment der COI Sequenzen keine Lücken finden, können die einzelnen Nucleotid-Positionen als homolog betrachtet werden. Jede Art besitzt eine Reihe einzigartiger (‘privater’) Positionen, die als diagnostische Merkmale benutzt werden können um die Art zu definieren und zu identifizieren.
Filière des produits à usage médicinal issus de Cordyla pinnata, Detarium microcarpum et Detarium senegalense au Sénégal
Authors: DIENG Sara Danièle , Niang-Diop Fatimata , Diop Mamadou , Goudiaby Assane , Sambou Bienvenu , Lykke Anne Mette 
Published: December 2020

Cette étude avait pour objectifs : 1) d’identifier et de caractériser les acteurs impliqués dans la filière des produits à usage médicinal tirés de Cordyla pinnata, Detarium microcarpum et Detarium senegalense au Sénégal; 2) d’analyser l’organisation de cette filière et l’importance des parties utilisées ; 3) d’analyser la commercialisation de ces produits ; 4) d’identifier les forces, faiblesses, opportunités et menaces de la filière. L’échantillonnage en boule de neige a été utilisé et a permis d’interroger, à l’aide de guides d’entretien 13 tradipraticiens locaux, 3 récolteurs et 17 herboristes. Les résultats ont révélé que les acteurs de cette filière, majoritairement des hommes, entretenaient des relations de coopération et qu’ils bénéficiaient de l’appui de la société civile en termes de formation et d’organisation. Les racines et les écorces de Cordyla pinnata et Detarium microcarpum étaient plus utilisées tandis que celles de Detarium senegalense étaient peu commercialisées. Les écorces, les racines et les feuilles étaient vendues entre 0,11 et 0,29Euro/100g. Une partie des écorces était transformée en poudre avant d’être commercialisée chez les herboristes entre 1,05 Euro/100g (pour Cordyla pinnata) et 1,52 Euro/100g (Detarium microcarpum). Les prix étaient plus élevés à Dakar. Les parties tirées de Cordyla pinnata étaient essentiellement utilisés contre les parasitoses intestinales tandis que celles de Detarium microcarpum et dans une moindre mesure celles de Detarium senegalense servaient à soigner les dermatoses. Les faiblesses de cette filière concernaient essentiellement l’exploitation anarchique de la ressource et la raréfaction saisonnière de certains produits tandis que l’éloignement des sites d’approvisionnement menaçait son bon fonctionnement.
Mots clés : produits à usage médicinal, Cordyla pinnata, Detarium microcarpum, Detarium senegalense, filière, Sénégal.
Spectroscopic evidence for the Fe3+ spin transition in iron-bearing δ-AlOOH at high pressure
Authors: Su Xiaowan , Zhao Chaoshuai , Xu Liangxu , Lv Chaojia , Song Xitong , Ishii Takayuki , Xiao Yuming , Chow Paul , Sun Qiang , Liu Jin 
Published: December 2020

Abstractδ-AlOOH has emerged as a promising candidate for water storage in the lower mantle and could have delivered water into the bottom of the mantle. To date, it still remains unclear how the presence of iron affects its elastic, rheological, vibrational, and transport properties, especially across the spin crossover. Here, we conducted high-pressure X-ray emission spectroscopy experiments on a δ-(Al0.85Fe0.15) OOH sample up to 53 GPa using silicone oil as the pressure transmitting medium in a diamond-anvil cell. We also carried out laser Raman measurements on δ-(Al0.85Fe0.15)OOH and δ-(Al0.52Fe0.48)OOH up to 57 and 62 GPa, respectively, using neon as the pressure-transmitting medium. Evolution of Raman spectra of δ-(Al0.85Fe0.15)OOH with pressure shows two new bands at 226 and 632 cm−1 at 6.0 GPa, in agreement with the transition from an ordered (P21nm) to a disordered hydrogen bonding structure (Pnnm) for δ-AlOOH. Similarly, the two new Raman bands at 155 and 539 cm−1 appear in δ-(Al0.52Fe0.48)OOH between 8.5 and 15.8 GPa, indicating that the incorporation of 48 mol% FeOOH could postpone the order-disorder transition upon compression. On the other hand, the satellite peak (Kβ′) intensity of δ-(Al0.85Fe0.15)OOH starts to decrease at ~30 GPa and it disappears completely at 42 GPa. That is, δ-(Al0.85Fe0.15)OOH undergoes a gradual electronic spin-pairing transition at 30–42 GPa. Furthermore, the pressure dependence of Raman shifts of δ-(Al0.85Fe0.15)OOH discontinuously decreases at 32–37 GPa, suggesting that the improved hydrostaticity by the use of neon pressure medium could lead to a relatively narrow spin crossover. Notably, the pressure dependence of Raman shifts and optical color of δ-(Al0.52Fe0.48)OOH dramatically change at 41–45 GPa, suggesting that it probably undergoes a relatively sharp spin transition in the neon pressure medium. Together with literature data on the solid solutions between δ-AlOOH and ε-FeOOH, we found that the onset pressure of the spin transition in δ-(Al,Fe)OOH increases with increasing FeOOH content. These results shed new insights into the effects of iron on the structural evolution and vibrational properties of δ-AlOOH. The presence of FeOOH in δ-AlOOH can substantially influence its high-pressure behavior and stability at the deep mantle conditions and play an important role in the deep-water cycle.
ESTADO NUTRICIONAL DE IODO NA GESTAÇÃO E SUA INFLUÊNCIA NA SAÚDE DO BINÔMIO MÃE-FILHO
Authors: Coqueiro Karen Thayane De Oliveira , Pereira Renata Junqueira 
Published: December 2020

A gravidez está associada a um declínio do iodo no organismo materno, que pode levar a hipotireoidismo em áreas com deficiência de iodo, por esta razão, é fundamental uma ingestão adequada durante a gravidez. Verifica-se que a insuficiente ingestão materna de iodo afeta negativamente a saúde do feto e do recém-nascido, com consequências que perdurarão por toda a vida. Esta revisão teve como objetivo descrever a importância do iodo para o período gestacional e os efeitos relacionados à sua deficiência no binômio mãe-filho. Sabe-se que o iodo é essencial para o desenvolvimento do cérebro fetal em etapas tais como a neurogênese, a diferenciação de células neuronais e gliais, a mielinização, a migração e a sinaptogênese. Nesse sentido, a deficiência de iodo na gestação e na vida extrauterina pode ocasionar um conjunto de anormalidades denominadas distúrbios da deficiência de iodo, que incluem um espectro de diferentes doenças, como hipotireoidismo, natimortos, bócio, anomalias congênitas, crescimento e desenvolvimento infantis prejudicados; atraso no desenvolvimento psicomotor; redução da capacidade cognitiva; além de elevarem as taxas de mortalidade fetal e infantil e serem considerados as principais causas evitáveis de deficiência mental na infância e cretinismo. Futuros estudos sobre o papel da deficiência iódica na saúde materna e fetal ainda são necessários para elucidar de que forma o iodo impacta nos desfechos gestacionais e perinatais e as possibilidades de intervenção para se evitar ou minimizar os efeitos indesejáveis de sua deficiência.
Organization of Training Process for Preparation
to 10x10 Shuttle Run Exam
Authors: Malkov Andrei Alekseevich 
Published: December 2020

Analysis of literature sources showed insufficient coverage of the issue of preparation for passing the standards in the exercise Shuttle run 10*10 m. You can find a General description of the exercise, but without specific recommendations, or General recommendations for preparing for the 60 – 100m test. Although the method of preparation for the 60, 100 m competition is similar to the method of preparation for the 10*10 m shuttle run, it still has a number of fundamental differences. This article contains tools, methods, and practical recommendations for preparing for implementation. standard shuttle run 10*10 m.