bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between serum zinc, HOMA2 parameters and glycemic status in a regional Australian hospital population
Authors: Lim Sarah , Robinson Ainsley M. , Bhattacharya Arup , Kilmartin John , Milton Abul H. , Islam Md Rafiqul 
Published: November 2020

BACKGROUND: Previous studies demonstrated lower serum zinc among prediabetics and diabetics, compared to normoglycemics, however no current data is available for regional Australia. OBJECTIVE: We aimed to determine the relationship between serum zinc, glycemic status and Homeostasis Model Assessment (HOMA2) parameters in a regional Australian hospital population. METHODS: Retrospective review of patients presenting to a regional Australian hospital between June-2004 and April-2017 was conducted. Patients ordered for fasting blood glucose (FBG)+serum zinc; or FBG+serum insulin; or FBG+serum zinc+serum insulin were included. Serum zinc, FBG, serum insulin, lipid profile, vitamin-D and demographic information were collected. β-cell function, insulin resistance and insulin sensitivity were calculated by HOMA2 calculator. RESULTS: Three hundred and thirteen patient records were retrieved: 75% normoglycemic, 19% prediabetic, 6% diabetic. Serum zinc was lowest in diabetics and lower in prediabetics than normoglycemics. In simple linear regression among all participants, higher serum zinc associated with increased insulin sensitivity, decreased insulin resistance and decreased β-cell function. CONCLUSIONS: The low serum zinc status exhibited in diabetic and prediabetic individuals may play a role in insulin resistance pathogenesis. Higher zinc levels associated with greater insulin sensitivity and lower insulin resistance signifying the importance of investigating zinc supplementation in prediabetics to prevent or delay diabetes in future studies.
Inventarisasi Bahan Tambahan Makanan (BTM) Penyebab Positif Palsu Pada Uji Kualitatif Boraks Dengan Filtrat Ubi Ungu (Ipomoea Batatas L)
Authors: Andini Arista Suci , Syuhriatin Syuhriatin , Maftuha Diaul 
Published: November 2020

Natrium Tetraborate (boraks) merupakan jenis bahan tambahan makanan (BTM) berfungsi sebagai sebagai pengawet yang dilarang Kementerian Kesehatan RI No 235/Menkes/VI/1984. Konsumsi makanan yang mengandung boraks dapat menyebabkan gangguan otak, hati, lemak, ginjal, demam, anuria, koma, bahkan kematian. Analisa kualitatif boraks kini mulai dikembangkan memanfaatkan bahan-bahan alam, salah satunya ubi ungu. Ekstrak Ubi Ungu dapat digunakan sebagai pendeteksi boraks karena ekstrak Ubi Ungu mengandung senyawa antosianin. antosianin dapat mendeteksi adanya kandungan boraks pada makanan akan tetapi sering terjadi positif palsu pada uji. Penelitian ini dilakukan di Kesehatan Pengujian Kalibrasi dan Penunjang Medis Provinsi Nusa Tenggara Barat dengan tujuan untuk mengetahui BTM yang menyebabkan munculnya positif palsu deteksi borak. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa Bahan tambahan makanan dengan hasil positif palsu pada uji kualitatif boraks dengan filtrat ubi ungu (Ipomoea Batatas L) yaitu Natrium Benzoat, Monosodium Glutamat, Natrium Tripoliposfat, Natrium Bikarbonat, Bikarbonat, Natrium Karbonat, Natrium Polipospat, dan Carboxyl Methyl Cellulose
Pengolahan Serum Hemolisis Menggunakan Reagen Anti-Rh Pada Pemeriksaan Glukosa Darah Metode GOD-PAP
Authors: Rahmawati Ira 
Published: November 2020

Pemeriksaan glukosa serum dengan metode GOD – PAP dapat diganggu dengan adanya hemoglobin di dalam serum akibat pecahnya eritrosit dan mengakibatkan serum menjadi hemolisis. Penambahan reagen anti – Rh kedalam serum dapat mengikat hemoglobin sehingga serum hemolisis dapat dipisahkan antara bagian serum dan bagian hemoglobinnya. Penelitian ini bertujuan untuk mengetahui pengaruh reagen anti – Rh sebagai pengendap hemoglobin pada serum hemolisis dan untuk mengetahui serum dapat digunakan kembali untuk pemeriksaan glukosa darah setelah penambahan reagen anti –Rh pada serum hemolisis. Metode penelitian ini bersifat eksperimen dengan melihat penurunan kadar glukosa darah setelah penambahan reagen anti – Rh pada serum hemolisis yang dibandingkan dengan kadar glukosa serum hemolisis yang selanjutnya dibandingkan dengan kadar glukosa serum normal. Data kemudian dianalisis dengan uji Friedman. Hasil menunjukkan serum hemolisis berbeda signifikan dengan P 0,008 yang lebih kecil dari alpha (0,05) yang dibandingkan dengan serum normal. Penggunaan reagen anti – Rh pada serum hemolisis menunjukkan hasil yang tidak berbeda signifikan dengan P 0,51 yang lebih besar dari alpha (0,05) dibandingkan dengan serum normal. Serum hemolisis dengan penambahan reagen anti – Rh menunjukkan hasil yang berbeda signifikan dengan P 0,008 yang lebih kecil dari alpha (0,05) dibandingkan dengan serum hemolisis. Reagen anti-rh dapat digunakan dalam pengolahan serum hemolisis.
TUTELA PROVISÓRIA SATISFATIVA NAS CONTRARRAZÕES RECURSAIS
Authors: Aguiar Neto Francisco Silveira de , Hecktheuer Fabio Rychecki 
Published: November 2020

O presente trabalho tem como propósito estudar a regulamentação da tutela provisória no âmbito das contrarrazões recursais de acordo com o CPC/2015, buscando sistematizá-la à luz da legislação, da jurisprudência e da doutrina, além de tratar de algumas controvérsias e particularidades sobre o assunto.
Palavras-Chave: Tutela Provisória. Recursos. Efeitos dos Recursos. Contrarrazões. Igualdade Processual.

PROVISIONAL PROTECTION IN THE CONTEXT OF COUNTERARGUMENTS IN APPEALS
Abstract: The purpose of this paper is to study the regulation of provisional protection in the context of counterarguments in appeals according to the Brazilian Civil Procedure Code of 2015, seeking to systematize it in the light of legislation, jurisprudence and doctrine, in addition to addressing some controversies and particularities about the subject.
Keywords: Provisional Protection. Appeals. Effects of Appeals. Counterarguments. Procedural Equality.
The Genetic Dissection of Ace2 Expression Variation in the Heart of Murine Genetic Reference Population
Authors: Xu Fuyi , Gao Jun , Munkhsaikhan Undral , Li Ning , Gu Qingqing , Pierre Joseph F. , Starlard-Davenport Athena , Towbin Jeffrey A. , Cui Yan , Purevjav Enkhsaikhan , Lu Lu 
Published: November 2020

Background: A high inflammatory and cytokine burden that induces vascular inflammation, myocarditis, cardiac arrhythmias, and myocardial injury is associated with a lethal outcome in COVID-19. The SARS-CoV-2 virus utilizes the ACE2 receptor for cell entry in a similar way to SARS-CoV. This study investigates the regulation, gene network, and associated pathways of ACE2 that may be involved in inflammatory and cardiovascular complications of COVID-19.Methods: Cardiovascular traits were determined in the one of the largest mouse genetic reference populations: BXD recombinant inbred strains using blood pressure, electrocardiography, and echocardiography measurements. Expression quantitative trait locus (eQTL) mapping, genetic correlation, and functional enrichment analysis were used to identify Ace2 regulation, gene pathway, and co-expression networks.Results: A wide range of variation was found in expression of Ace2 among the BXD strains. Levels of Ace2 expression are negatively correlated with cardiovascular traits, including systolic and diastolic blood pressure and P wave duration and amplitude. Ace2 co-expressed genes are significantly involved in cardiac- and inflammatory-related pathways. The eQTL mapping revealed that Cyld is a candidate upstream regulator for Ace2. Moreover, the protein–protein interaction (PPI) network analysis inferred several potential key regulators (Cul3, Atf2, Vcp, Jun, Ppp1cc, Npm1, Mapk8, Set, Dlg1, Mapk14, and Hspa1b) for Ace2 co-expressed genes in the heart.Conclusions:Ace2 is associated with blood pressure, atrial morphology, and sinoatrial conduction in BXD mice. Ace2 co-varies with Atf2, Cyld, Jun, Mapk8, and Mapk14 and is enriched in the RAS, TGFβ, TNFα, and p38α signaling pathways, involved in inflammation and cardiac damage. We suggest that all these novel Ace2-associated genes and pathways may be targeted for preventive, diagnostic, and therapeutic purposes in cardiovascular damage in patients with systemic inflammation, including COVID-19 patients.
Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
Authors: Van Damme Karel F. A. , Tavernier Simon , Van Roy Nele , De Leeuw Elisabeth , Declercq Jozefien , Bosteels Cédric , Maes Bastiaan , De Bruyne Marieke , Bogaert Delfien , Bosteels Victor , Hoste Levi , Naesens Leslie , Maes Piet , Grifoni Alba , Weiskopf Daniela , Sette Alessandro , Depuydt Pieter , Van Braeckel Eva , Haerynck Filomeen , Lambrecht Bart N. 
Published: November 2020

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.
Hemodynamic Effect of the Last Finishing Coils in Packing the Aneurysm Neck
Authors: Wan Hailin , Lu Gang , Huang Lei , Ge Liang , Jiang Yeqing , Li Gaohui , Leng Xiaochang , Xiang Jianping , Zhang Xiaolong 
Published: November 2020

Background: Using the finishing coils to densely pack the aneurysm neck is necessary. However, the exact hemodynamic effect of finishing coils in packing the aneurysm neck is unknown.Objective: To evaluate the hemodynamic characteristics of finishing coils to densely pack the aneurysm neck, using finite element method simulation.Methods: A computational study was performed based on a 44-year-old female patient with an unruptured wide-necked carotid-ophthalmic artery aneurysm treated with low-profile visualized intraluminal support stent-assisted coil embolization. Four computational fluid dynamics models including pre-treatment, post-stenting, common stent-assisted coil embolization (SACE), and common SACE with finishing coils were evaluated qualitatively and quantitatively.Results: Compared with the baseline of pretreatment model (100%), sac-averaged velocity in post-stenting, common SACE, and common SACE with finishing coil models decreased to 95.68%, 24.38%, and 13.20%, respectively; high flow volume (&gt;0.1 m/s) around the aneurysm neck decreased to 92.19%, 9.59%, and 5.57%, respectively; and mean wall shear stress increased or decreased to 107%, 25.94%, and 23.89%, respectively.Conclusion: Finishing coils to densely pack the aneurysm neck can generate favorable hemodynamic modifications, which may decrease the recurrence.
Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo
Authors: Xie Ke-Hang , Liu Ling-Ling , Su Chu-Yin , Huang Xiao-Feng , Wu Bao-Xing , Liu Run-Ni , Li Hua , Chen Qing-Qing , He Jia-Sheng , Ruan Yong-Kun 
Published: November 2020

Objective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were retrospectively analyzed in 70 patients with new-onset idiopathic BPPV and 140 age- and sex-matched healthy controls (HCs).Results: Serum UA, BIL, ALB, and CRE levels were significantly lower in the BPPV group than the HC group. Furthermore, serum levels of BIL and ALB were significantly lower in the BPPV group when compared by sex. Multiple stepwise logistic regression revealed that a reduction in serum ALB was independently related to BPPV (odds ratio = 0.688; 95% confidence interval = 0.607– 0.780). Receiver operating characteristic analyses revealed a cut-off value of 45.15 g/L for ALB with a sensitivity of 74.29% (62.97– 83.07%) and specificity of 73.57% (65.71– 80.18%).Conclusions: Serum levels of UA, BIL, ALB, and CRE were lower in BPPV patients, indicating a lower antioxidant status. Furthermore, a reduction in serum ALB was independently associated with BPPV. These results provide insights into the possible roles of oxidative stress in the pathogenesis of BPPV.
Measuring the Cognitive Workload During Dual-Task Walking in Young Adults: A Combination of Neurophysiological and Subjective Measures
Authors: Hoang Isabelle , Ranchet Maud , Derollepot Romain , Moreau Fabien , Paire-Ficout Laurence 
Published: November 2020

Background: Walking while performing a secondary task (dual-task (DT) walking) increases cognitive workload in young adults. To date, few studies have used neurophysiological measures in combination to subjective measures to assess cognitive workload during a walking task. This combined approach can provide more insights into the amount of cognitive resources in relation with the perceived mental effort involving in a walking task.Research Question: The objective was to examine cognitive workload in young adults during walking conditions varying in complexity.Methods: Twenty-five young adults (mean = 24.4 ± 5.4) performed four conditions: (1) usual walking, (2) simple DT walking, (3) complex DT walking and (4) standing while subtracting. During the walking task, mean speed, cadence, stride time, stride length, and their respective coefficient of variation (CV) were recorded. Cognitive workload will be measured through changes in oxy- and deoxy-hemoglobin (ΔHbO2 and ΔHbR) during walking in the dorsolateral prefrontal cortex (DLPFC) and perceived mental demand score from NASA-TLX questionnaire.Results: In young adults, ΔHbO2 in the DLPFC increased from usual walking to both DT walking conditions and standing while subtracting condition. ΔHbO2 did not differ between the simple and complex DT and between the complex DT and standing while subtracting condition. Perceived mental demand gradually increased with walking task complexity. As expected, all mean values of gait parameters were altered according to task complexity. CV of speed, cadence and stride time were significantly higher during DT walking conditions than during usual walking whereas CV of stride length was only higher during complex DT walking than during usual walking.Significance: Young adults had greater cognitive workload in the two DT walking conditions compared to usual walking. However, only the mental demand score from NASA-TLX questionnaire discriminated simple from complex DT walking. Subjective measure provides complementary information to objective one on changes in cognitive workload during challenging walking tasks in young adults. These results may be useful to improve our understanding of cognitive workload during walking.
Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model
Authors: Yang Jianling , Guo Zhengyang , Liu Xu , Liu Qi , Wu Meng , Yao Xueting , Liu Yang , Cui Cheng , Li Haiyan , Song Chunli , Liu Dongyang , Xue Lixiang 
Published: November 2020

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients and still under debate due to the uncertainty regarding the effectiveness and safety, and there is still lack of the systematic study on the toxicity of these two drugs. To further uncover the toxicity profile of CQ and HCQ in different tissues, we evaluated the cytotoxicity of them in eight cell lines and further adopted the physiologically based pharmacokinetic models to predict the tissue risk, respectively. Retina, myocardium, lung, liver, kidney, vascular endothelium, and intestinal epithelium originated cells were included in the toxicity evaluation of CQ and HCQ, respectively. The proliferation pattern was monitored in 0–72 h by IncuCyte S3. CC50 and the ratio of tissue trough concentrations to CC50 (RTTCC) were brought into predicted toxicity profiles. Compared to CQ, HCQ was found to be less toxic in six cell types except Hep3B and Vero cells. In addition, RTTCC was significantly higher in CQ treatment group compared to HCQ group, which indicates relative safety of HCQ. To further simulate the situation of the COVID-19 patients who suffered the dyspnea and hypoxemia, we also tested the cytotoxicity upon hypoxia and normoxia (1, 5 vs. 21% O2). It was found that the cytotoxicity of CQ was more sensitive to hypoxia compared with that of HCQ, particularly in liver originated cells. Both CQ and HCQ showed cytotoxicity in time-dependent manner which indicates the necessity of short period administration clinically.
Risk of Bleeding Associated With Ibrutinib in Patients With B-Cell Malignancies: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wang Jinjin , Zhao Ailin , Zhou Hui , Zhu Jinbing , Niu Ting 
Published: November 2020

Background: Ibrutinib is an oral covalent Bruton’s tyrosine kinase inhibitor that has been approved for chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia and some other B-cell malignancies. Some studies have found an increased risk of bleeding with ibrutinib. Some studies, however, found no significant differences in the risk of major bleeding between patients treated with ibrutinib and those with other regimens. So, a systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to estimate the risk of bleeding associated with ibrutinib in patients with B-cell malignancies.Methods: A systematic search of PUBMED, EMBASE, Central Register of Controlled Trials, and ClinicalTrials.gov was conducted from January 2000 to February 2020 to identify RCTs by comparing ibrutinib with other agents or placebo in B-cell malignancies. The RevMan software (version 5.3) was used to carry out this analysis, and the analyzed data were represented by risk ratios (RR) and 95% confidence intervals (CI).Results: There were 11 eligible RCTs (4,288 patients). All studies reported major bleeding, and seven studies reported overall bleeding (any-grade bleeding). Ibrutinib was associated with a significantly increased risk of bleeding (overall bleeding and major bleeding) in patients with B-cell malignancies [RR = 2.56, 95% CI 1.68–3.90, p &lt; 0.0001 and RR = 2.08, 95% CI 1.36–3.16, p = 0.0006, respectively]. The bleeding (overall bleeding and major bleeding) risk in patients with CLL was more obvious [RR = 3.08, 95% CI 2.07–4.58, p &lt; 0.00001 and RR = 2.46, 95% CI 1.37–4.41, p = 0.003, respectively]. There were no statistically significant differences for risk of bleeding between the subgroups based on dose and treatment setting.Conclusion: Ibrutinib was associated with a significantly higher risk of bleeding (both overall bleeding and major bleeding) in patients with B-cell malignancies, especially in CLL.
Programa bolsa família em Belém/PA
Authors: Braga Cilene Sebastiana , Portela Roselene de Souza , Carvalho Jessica Larissa da Silva 
Published: November 2020

O presente trabalho objetiva analisar o Programa Bolsa Família para além do recurso monetário, identificando se ele tem possibilitado mudanças significativas nas condições de vida das famílias usuárias de forma a contribuir para a efetivação dos direitos sociais e melhores condições de vida. Tendo como base o município de Belém, no estado do Pará, procura-se conhecer quais as repercussões do Programa na vida das famílias usuárias. Foi realizada pesquisa bibliográfica e pesquisa documental, também foram extraídos dados do Ministério do Desenvolvimento Social que contém informações acerca dos usuários cadastrados nos programas sociais no ano de 2016. Dentre os resultados do trabalho pode-se dizer que o PBF, mesmo suprindo necessidades imediatas dos usuários, não tem contribuído decisivamente para a elevação das condições de vida dos usuários, que continuam em condições precárias de trabalho renda e moradia.
DTM e dor orofacial: perspectivas curriculares das faculdades de Odontologia do Sudeste brasileiro
Authors: Viana Faria Luan , De Lima Medeiros Yuri , Fernandes Lopes Danielle , Campos Durso Braz 
Published: November 2020

Introdução: A dor orofacial (DO) e as disfunções temporomandibulares (DTM) apresentam alta prevalência na população, sendo causa de grande sofrimento para os pacientes. Para formar clínicos gerais aptos em reconhecerem e tratarem tais distúrbios é necessário que as Instituições de Ensino Superior (IES) ofertem este conteúdo de forma satisfatória durante a graduação. Objetivo: Identificar e quantificar a presença da disciplina de DTM e DO nas grades curriculares dos cursos de graduação em Odontologia, bem como características curriculares da disciplina quando presente. Material e Métodos: A amostra da pesquisa constitui-se de todas as faculdades de Odontologia do Sudeste brasileiro em funcionamento no mês de março de 2019, que estavam com cursos ativos e credenciados no portal e-MEC do Ministério da Educação do Brasil, e que disponibilizaram acesso a matriz curricular por meio de ferramentas online (website oficial ou e-mail). Os dados foram analisados no programa GraphPad Prism 5.0. Resultados: Das 176 IES da região Sudeste, 144 (81,8%) foram incluídas no estudo por preencherem os critérios de inclusão. Destas, apenas 36% apresentam disciplinas relacionadas à DTM e DO em suas matrizes curriculares, sendo mais ofertada em IES públicas (52,6%) do que privadas (33,6%), para p=0,1275. A respeito da natureza da disciplina, é predominantemente obrigatória nas IES privadas, e não obrigatória nas IES públicas (p=0,0073). Como aspecto positivo, foi observado que em relação ao tipo de conteúdo abordado, disciplinas teórico-práticas são abordadas na maioria das instituições (59,37%). A carga horária (CH) média da disciplina é de 58,98h (DP=20,37), sendo maior nas IES públicas. Conclusão: Nossos resultados demostram que a maioria dos cursos de Odontologia do Sudeste brasileiro (63,8%) não oferecem disciplinas de DTM e DO, especialmente IES privadas.
UPAYA MEMPERBAIKI EKONOMI BERAS DI PROVINSI NUSA TENGGARA TIMUR ANALISIS DATA SEKUNDER TAHUN 2003-2017)
Authors: Teda Fransisca Erna , Benu Fredrik L , Wiendiyati Wiendiyati 
Published: November 2020

The aim of this research were to review the state of rice industry over the past 15 years (2003-2017) based on the demand and supply situation in East Nusa Tenggara. The development of the price of rice, the factors that influence the demand and supply, and determine the policy impact of rice demand and supply in East Nusa Tenggara Province. This research uses the econometric model, that is a simultant structural equation,which was indentified by the order condition and it was approaches using Two Stage Least Square (2SLS). The data used in this research was the time series of secondary data during 15 years period from 2003-2017 that was provided by Central Startics Office, the National Logistics Authority, the NTT Agricultural Bureau and other publications related to this investigation.
The analysis showed that the amount of rice production was really depended on harvest area, rice consumption, rice supply and rice production in the previous year. The retail price of rice was responded to the price of corn and the demand for rice in the long term, while in the short term it only responded to the price of corn. The amount of rice consumption responded to rice production, rice prices and rice demand. Rice imports reacted to rice production, rice prices, corn prices and rice consumption in the long run.
Based on the results of the research, it was suggested that the area of irrigation needs to be extended,in each region of East Nusa tenggara Province, particularly technical irrigation in order to increase the rice production, and it es neededto do diversification programs in order to reduce dependency rice. The weakness of this research was it used the inpure simultan model.