bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injection augmentation and endoscopic repair of type 1 laryngeal clefts: Development of a management algorithm
Authors: Isaac Andre , Svystun Orysya , Johannsen Wendy , El-Hakim Hamdy 
Published: July 2020

Objectives To describe indications for injection augmentation (IA), endoscopic repair (ER) and conservative methods for the management of type 1 laryngeal cleft (LC1) and propose a management algorithm. We also aimed to compare success of IA and ER and determine independent predictors of treatment failure. Methods Retrospective study of patients diagnosed with LC1 at a Pediatric Otolaryngology referral centre between 2004 and 2016. All had pre-operative instrumental swallowing evaluation (VFSS/FEES), and were managed with a combination of conservative measures, IA and/or ER. We collected demographics, symptoms, comorbidities, VFSS/FEES results, and operative details. The primary outcome was symptom resolution by parental report. The secondary outcome was predictors of treatment failure. Results 88 patients were included in the analysis, with mean age 26 ± 25 months. Most presented with choking events (68%) or recurrent pneumonias (48%). In total, there were 55 IA performed and 45 ER. Of the patients who received IA, 19 required subsequent ER. 95% had symptom improvement, 67% had complete resolution. IA had a 56% long-term success rate, whereas that for ER was 85%. Tube feeding at initial evaluation was an independent predictor of treatment failure (HR 11.33 [1.51–84.97], p = 0.018). Conclusions LC1 can be effectively managed with a combination of IA and ER with favorable results. Failure to respond to IA does not preclude ER, and both have their role in management. Patients who are tube fed have a higher probability of treatment failure. We propose a management algorithm that includes reasoning for conservative approaches, and reduces exposure to general anesthesia.
The semantic conservation of architectural heritage: the missing values
Authors: Taher Tolou Del Mohammad Sadegh , Saleh Sedghpour Bahram , Kamali Tabrizi Sina 
Published: July 2020

Abstract
The conservation of the architectural heritage has enjoyed a long course of development over the recent decades. Conservation practice is based on the values offered by the architectural heritage resources for different individuals, groups, societies, and governments. Since there is no serious and comprehensive research on the semantic values, the present study was conducted to identify all the influential semantic values in the architectural conservation process and to determine the importance of each value based on the published literature. To this end, more than 100 scientific documents, statements, and charters were analyzed and then, 40 semantic values were identified. The snowball sampling method was used to select the papers. In this study, the qualitative content analysis was used to evaluate the relationship between the architectural heritage and conservation, and the quantitative content analysis was used to assess the relationship between the semantic values and conservation. According to the results of the content analysis, it can be concluded that the conservation of architectural heritage can be investigated and analyzed at three levels: people, experts, and governments, and the holistic conservation of the architectural heritage can be achieved only by the joint cooperation among all the three levels. Also, the results showed that the cultural value, economic value, historical value, and identity greatly influence the semantic conservation of the architectural heritage.
Recent changes in breeding abundance and distribution of the Common Pochard (Aythya ferina) in its eastern range
Authors: Mischenko Alexander , Fox Anthony David , Švažas Saulius , Sukhanova Olga , Czajkowski Alexandre , Kharitonov Sergey , Lokhman Yuri , Ostrovsky Oleg , Vaitkuvienė Daiva 
Published: July 2020

AbstractBackgroundThe Common Pochard (Aythya ferina) (hereafter Pochard), a widespread and common freshwater diving duck in the Palearctic, was reclassified in 2015 from Least Concern to Vulnerable IUCN status based on rapid declines throughout its range. Analysis of its status, distribution and the potential causes for the decline in Europe has been undertaken, but there has never been a review of its status in the major part of its breeding range across Russia to the Pacific coast.MethodsWe reviewed the scientific literature and unpublished reports, and canvassed expert opinion throughout Russia to assess available knowledge about changes in the species distribution and abundance since the 1980s.ResultsWhile accepting available information may not be representative throughout the entire eastern range of the species, the review found marked declines in Pochard breeding abundance in the last two decades throughout European Russia. Pochard have also declined throughout Siberia. Declines throughout the steppe region seemed related to local drought severity in recent years, necessitating further research to confirm this climate link at larger spatial scales. Declines in the forest and forest-steppe regions appeared related to the major abandonment of fish farms in western Russia that had formerly provided habitat for breeding Pochard. However, hyper-eutrophication of shallow eutrophic lakes, cessation of grazing and haymaking in floodplain systems necessary to maintain suitable nesting habitat and disappearance of colonies of the Black-headed Gull (Chroicocephalus ridibundus) in a number of wetlands were also implicated. Increasing invasive alien predator species (e.g. American MinkNeovison visonand Raccoon DogNyctereutes procyonoides) and increasing spring hunting were also thought to contribute to declines. Reports of expansion in numbers and range only came from small numbers occurring in the Russian Far East, including on the border with China and the long-established isolated population on Kamchatka Peninsula.ConclusionsWidespread declines throughout the eastern breeding range of the Pochard give continued cause for concern. Although we could address all the potential causal factors identified above by management interventions, we urgently need better information relating to key factors affecting site-specific Pochard breeding success and abundance, to be able to implement effective actions to restore the species to more favourable conservation status throughout its breeding range.
Seasonal and population differences in migration of Whimbrels in the East Asian–Australasian Flyway
Authors: Kuang Fenliang , Coleman Jonathan T. , Hassell Chris J. , Leung Kar-Sin K. , Maglio Grace , Ke Wanjuan , Cheng Chuyu , Zhao Jiayuan , Zhang Zhengwang , Ma Zhijun 
Published: July 2020

AbstractBackgroundConserving migratory birds is challenging due to their reliance on multiple distant sites at different stages of their annual life cycle. The concept of “flyway”, which refers to all areas covered by the breeding, nonbreeding, and migrating of birds, provides a framework for international cooperation for conservation. In the same flyway, however, the migratory activities of the same species can differ substantially between seasons and populations. Clarifying the seasonal and population differences in migration is helpful for understanding migration ecology and for identifying conservation gaps.MethodsUsing satellite-tracking we tracked the migration of Whimbrels (Numenius phaeopus variegatus) from nonbreeding sites at Moreton Bay (MB) and Roebuck Bay (RB) in Australia in the East Asian–Australasian Flyway. Mantel tests were used to analyze the strength of migration connectivity between the nonbreeding and breeding sites of MB and RB populations. Welch’sttest was used to compare the migration activities between the two populations and between northward and southward migration.ResultsDuring northward migration, migration distance and duration were longer for the MB population than for the RB population. The distance and duration of the first leg flight during northward migration were longer for the MB population than for the RB population, suggesting that MB individuals deposited more fuel before departing from nonbreeding sites to support their longer nonstop flight. The RB population exhibited weaker migration connectivity (breeding sites dispersing over a range of 60 longitudes) than the MB population (breeding sites concentrating in a range of 5 longitudes in Far Eastern Russia). Compared with MB population, RB population was more dependent on the stopover sites in the Yellow Sea and the coastal regions in China, where tidal habitat has suffered dramatic loss. However, RB population increased while MB population decreased over the past decades, suggesting that loss of tidal habitat at stopover sites had less impact on the Whimbrel populations, which can use diverse habitat types. Different trends between the populations might be due to the different degrees of hunting pressure in their breeding grounds.ConclusionsThis study highlights that conservation measures can be improved by understanding the full annual life cycle of movements of multiple populations of Whimbrels and probably other migratory birds.
Quantitative 166Ho-microspheres SPECT derived from a dual-isotope acquisition with 99mTc-colloid is clinically feasible
Authors: Stella M. , Braat AJAT , Lam MGEH , de Jong HWAM , van Rooij R. 
Published: July 2020

Abstract
Purpose
Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (166Ho)-microspheres, and technetium-99 m (99mTc)-colloid was developed: 166Ho-microspheres used as scout and therapeutic particles, and 99mTc-colloid to identify the healthy liver. DI SPECT allows for an automatic and accurate estimation of absorbed doses, introducing true personalized dosimetry. However, photon crosstalk between isotopes can compromise image quality. This study investigates the effect of 99mTc downscatter on 166Ho dosimetry, by comparing 166Ho-SPECT reconstructions of patient scans acquired before (166Ho-only) and after additional administration of 99mTc-colloid (166Ho-DI).

Methods
The 166Ho-only and 166Ho-DI scans were performed in short succession by injecting 99mTc-colloid on the scanner table. To compensate for 99mTc downscatter, its influence was accounted for in the DI image reconstruction using energy window-based scatter correction methods. The qualitative assessment was performed by independent blinded comparison by two nuclear medicine physicians assessing 65 pairs of SPECT/CT. Inter-observer agreement was tested by Cohen’s kappa coefficient. For the quantitative analysis, two volumes of interest within the liver, VOITUMOR, and VOIHEALTHY were manually delineated on the 166Ho-only reconstruction and transferred to the co-registered 166Ho-DI reconstruction. Absorbed dose within the resulting VOIs, and in the lungs (VOILUNGS), was calculated based on the administered therapeutic activity.

Results
The qualitative assessment showed no distinct clinical preference for either 166Ho-only or 166Ho-DI SPECT (kappa = 0.093). Quantitative analysis indicated that the mean absorbed dose difference between 166Ho-DI and 166Ho-only was − 2.00 ± 2.84 Gy (median 27 Gy; p value < 0.00001), − 5.27 ± 8.99 Gy (median 116 Gy; p value = 0.00035), and 0.80 ± 1.08 Gy (median 3 Gy; p value < 0.00001) for VOIHEALTHY, VOITUMOR, and VOILUNGS, respectively. The corresponding Pearson’s correlation coefficient between 166Ho-only and 166Ho-DI for absorbed dose was 0.97, 0.99, and 0.82, respectively.

Conclusion
The DI protocol enables automatic dosimetry with undiminished image quality and accuracy.

Clinical trials
The clinical study mentioned is registered with Clinicaltrials.gov (NCT02067988) on 20 February 2014.
Exploration of the body–garment relationship theory through the analysis of a sheath dress
Authors: Carufel Robin , Bye Elizabeth 
Published: July 2020

AbstractThe apparel industry is replete with assumptions regarding the body-garment relationship. Traditional anthropometry focuses on linear body measurements, which are inadequate to describe and classify the human body-form for apparel pattern development. To enable the development of a body-form based block system, this case study explored the body-garment relationship for a sheath dress to determine if apparel block shapes could be categorized based on distinct body-form variations. A modified version of Gazzuolo’s (1985) body-garment relationship theory guided the development and analysis of the study. Pattern blocks were fit to 39 female subjects, with 16 dimensions extracted from specific pattern components and graphed to reveal between one and five groups per dimension. Visual analysis of the sample’s body scans revealed 27 body-form variations with 99 categorical descriptions. Categorical descriptions were compared to the dimensional values resulting in ten suggestions for a body-form based block system, and seventeen assumptions that require further analysis. In conclusion, this case study discovered multiple body-form variations across a single size, but block shapes could not be identified due to the wide variation in the sample. Future studies should assess a statistically significant sample of individuals with in-depth analysis of a single body region to determine if there are generalizable body-form variations across the population.
Repair of gastro-tracheobronchial fistula after esophagectomy for esophageal cancer using intercostal muscle and latissimus dorsi muscle flaps: a case report
Authors: Miyata Kazushi , Fukaya Masahide , Nagino Masato 
Published: July 2020

Abstract
Background
Gastro-tracheobronchial fistula after esophagectomy is a rare but life-threatening complication associated with high mortality. Several authors reported postoperative management of tracheobronchial fistula. However, treatment is demanding and challenging, and the strategy is still controversial.

Case presentation
A 64-year-old man underwent thoracoscopic esophagectomy with two-field lymph node dissection and gastric conduit reconstruction by an intrathoracic anastomosis for esophageal cancer at a local hospital in June 2013. After surgery, a gastro-tracheal fistula and a gastro-bronchial fistula of the left main bronchus were diagnosed, and the patient was referred to our hospital for the management of the gastro-tracheobronchial fistula. CT and bronchoscopy and esophagogastroduodenoscopy performed at our hospital revealed that the gastro-bronchial fistula of the left main bronchus was cured by packing with the omentum from the gastric conduit and the gastro-tracheal fistula located 3 cm above the carina remained open. We concluded that the fistula would not resolve without further surgical procedure. However, such an operation was expected to be difficult and to need much time due to severe adhesion among the gastric conduit and/or trachea, bronchus, lung, and chest wall. Therefore, a two-stage operation was planned for safety and outcome certainty. The first operation was performed to close the fistula in October 2013. The gastric conduit was separated from the trachea and resected; then, the fistula was sutured and covered by intercostal muscle and latissimus dorsi muscle flaps. A month after the first operation, reconstruction with pedunculated jejunum was performed via the percutaneous route. The patient’s postoperative course was uneventful.

Conclusion
If the omentum is not observed between the gastric conduit and the tracheobronchus when a gastro-tracheobronchial fistula occurs after esophagectomy, surgeons should perform surgical treatment because conservative treatment is unlikely to cure. During surgery, the use of two types of muscle flaps, such as the intercostal muscle and the latissimus dorsi muscle flaps, is helpful for the closure of gastro-tracheobronchial fistulas.
Outcomes after transcatheter aortic valve replacement in cancer survivors with prior chest radiation therapy: a systematic review and meta-analysis
Authors: Zafar Meer Rabeel , Mustafa Syed Farrukh , Miller Timothy W. , Alkhawlani Talal , Sharma Umesh C. 
Published: July 2020

Abstract
Background
Cancer survivors with prior chest radiation therapy (C-XRT) frequently present with aortic stenosis (AS) as the first manifestation of radiation-induced heart disease. They are considered high-risk for surgical valve replacement. Transcatheter aortic valve replacement (TAVR) is as an attractive option for this patient population but the outcomes are not well established in major clinical trials. The authors performed a systemic review and meta-analysis of clinical studies for the outcomes after TAVR in cancer survivors with prior C-XRT.

Methods
Online databases were searched from inception to April 2020 for studies evaluating the outcomes of TAVR in patients with and without C-XRT. We analyzed the pooled estimates (with their 95% confidence intervals) of the odds ratio (OR) for the all-cause mortality at 30-day and 1-year follow-ups, 4-point safety outcomes (stroke, major bleed, access-related vascular complications and need for a pacemaker), a 2-point efficacy outcome (mean aortic valve gradient and left ventricular ejection fraction) and worsening of congestive heart failure (CHF). Four studies were included following 2054 patients with and without prior C-XRT exposure (164 patients and 1890 patients respectively).

Results
The C-XRT group had similar 30-day mortality compared to the control group (OR 1.29, 95% CI 0.64 to 2.58, p = 0.48). The 1-year mortality was higher in the C-XRT group (OR 1.97, CI 1.15 to 3.39, p = 0.01). Apart from higher congestive heart failure (CHF) exacerbation in the C-XRT group (OR 2.03, CI 1.36 to 3.04, p = 0.0006), TAVR resulted in similar safety and efficacy outcomes in both groups.

Conclusion
TAVR in the C-XRT group has similar 30-day mortality, safety, and efficacy outcomes compared to the control group; however, they have higher 1-year mortality and CHF exacerbation. Including an oncologist to the cardiology team who considers cancer stage in the decision-making process and applying additional preoperative scores such as frailty indices may refine the risk assessment for these patients. The quality of analyzed data is modest, warranting randomized trials to assess the true benefits of TAVR in these patients.
Identification of potential crucial genes and key pathways in osteosarcoma
Authors: Liu Junwei , Wu Siyu , Xie Xiaoyu , Wang Ziming , Lei Qianqian 
Published: July 2020

Abstract
Background
The aim of this study is to identify the potential pathogenic and metastasis-related differentially expressed genes (DEGs) in osteosarcoma through bioinformatic analysis of Gene Expression Omnibus (GEO) database.

Results
Gene expression profiles of GSE14359, GSE16088, and GSE33383, in total 112 osteosarcoma tissue samples and 7 osteoblasts, were analyzed. Seventy-four normal-primary DEGs (NPDEGs) and 764 primary-metastatic DEGs (PMDEGs) were screened. VAMP8, A2M, HLA-DRA, SPARCL1, HLA-DQA1, APOC1 and AQP1 were identified continuously upregulating during the oncogenesis and metastasis of osteosarcoma. The enriched functions and pathways of NPDEGs include procession and presentation of antigens, activation of MHC class II receptors and phagocytosis. The enriched functions and pathways of PMDEGs include mitotic nuclear division, cell adhesion molecules (CAMs) and focal adhesion. With protein-protein interaction (PPI) network analyzed by Molecular Complex Detection (MCODE) plug-in of Cytoscape software, one hub NPDEG (HLA-DRA) and 7 hub PMDEGs (CDK1, CDK20, CCNB1, MTIF2, MRPS7, VEGFA and EGF) were eventually selected, and the most significant pathways in NPDEGs module and PMDEGs module were enriched in the procession and presentation of exogenous peptide antigen via MHC class II and the nuclear division, respectively.

Conclusions
By integrated bioinformatic analysis, numerous DEGs related to osteosarcoma were screened, and the hub DEGs identified in this study are possibly part of the potential biomarkers for osteosarcoma. However, further experimental studies are still necessary to elucidate the biological function and mechanism of these genes.
Unleashing the mysterious link between COVID-19 and a famous childhood vasculitis: Kawasaki disease
Authors: AbdelMassih Antoine Fakhry , AbdelAzeam Aisha Said , Ayad Aya , Kamel Aya Yasser , Khalil Ayah , Kotb Basma , Waheed Dina , Menshawey Esraa , Sefein Fady , Taha Farah , Ismail Habiba-Allah , Osman Ibrahim , Iskander John , El Wakil Lama , Rashad Lara , Arsanyous Mariem Badr , El Shershaby Meryam , Mansour Mina , Ashraf Mirette , Hafez Nada , Abuzeid Nadeen Mohamed , AbdElSalam Noheir Mahmoud-Nashaat , Hafez Nouran Gamal , Youssef Nourhan , Hozaien Rafeef , Saeed Rana , Kamel Dina , AbdelHameed Manal Ahmed , Ali Salma 
Published: July 2020

Abstract
Background
Coronavirus disease 2019 (COVID-19) emerged as a small outbreak in Wuhan rapidly progressing into the deadliest pandemic since the Spanish flu of 1918. The disease was deemed trivial in children, until the reporting, few days ago, of an emerging pediatric multi-inflammatory syndrome mimicking Kawasaki disease (KD).

Main body
This report reveals that coronaviridae were implicated in induction of several post-infectious vasculitides, namely, KD, AHEI, and HSP. This occurs in genetically susceptible individuals to vascular inflammation. Shared genetic susceptibilities between KD and CoV include genes encoding for CD 40, HLAB-15:03, and ACE. This leads to augmented inflammation with hypersecretion of cytokines especially IL-6.

Conclusion
The revealed relationships between KD and CoV can help to predict the risk of KD in COVID-19 patients through screening levels of upregulated cytokines. It might also signify that classic treatment of KD with IVIG might need to be replaced with anti-cytokine therapy in COVID-19 patients.
Safety and Efficacy of the Combination of Propofol and Ketamine for Procedural Sedation/Anesthesia in the Pediatric Population: A Systematic Review and Meta-analysis
Authors: Hayes Jason A. , Aljuhani Talal , De Oliveira Kyle , Johnston Bradley C. 
Published: July 2020

BACKGROUND:
Drugs such as propofol and ketamine are used alone or in combination to provide sedation for medical procedures in children. The purpose of this systematic review was to compare the safety and effectiveness of propofol and ketamine to other drug regimens.

METHODS:
We searched Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR), Web of Science, and the grey literature (meta-Register of Controlled Trials, ClinicalTrials.gov, and Google Scholar) for randomized controlled studies comparing intravenous propofol and ketamine to any other single or combination drug regimen administered to children undergoing diagnostic or therapeutic procedures. Meta-analyses were performed for primary (hemodynamic and respiratory adverse events) and secondary outcomes using RevMan 5.3. We assessed the risk of bias and the certainty (quality) evidence for all outcomes using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.

RESULTS:
Twenty-nine studies were included for analysis. Based on low-to-moderate quality evidence, we concluded that the use of propofol and ketamine may result in a slight-to-small reduction in the risk of hypotension, bradycardia, and apnea, and a slight increase in the risk of tachycardia, hypertension, and other respiratory adverse events, such as cough or laryngospasm. The ratio of propofol to ketamine and comparator drug regimen subgroups effects were important for desaturation and some secondary outcomes.

CONCLUSIONS:
The use of propofol and ketamine had a minimal effect on the incidence of adverse events and other secondary outcomes. Large-scale studies are required to more accurately estimate adverse event rates and the effects of propofol and ketamine on patient-important outcomes.