bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometry of Flexural Uplift by Continental Rifting in Corinth, Greece
Authors: Fernández‐Blanco David , de Gelder Gino , Lacassin Robin , Armijo Rolando 
Published: November 2019

AbstractUnderstanding early rifting of continental lithosphere requires accurate descriptions of up‐bended rift margins and footwalls that ought to correlate in space and time with the elastic flexural uplift that produces them. Here we characterize the geometry of elastic flexural uplift by continental rifting at its spatiotemporal scale in nature (tens of kilometers; 104–106 years) using geomorphic evidence along the uplifting margin of the Corinth Rift, Greece. Our geomorphic analyses of space‐borne topography novelly outline the coherent elastic flexure of continental lithosphere along and across the rift margin and throughout faulting (~106 years), as defined by the distribution of footwall uplift south of the active bounding fault. Topography and river drainages outline an elastic flexure signal that increases exponentially toward the bounding fault across the footwall for >50 km and changes in amplitude along the footwall following a parabola that decays from the rift center and has a >60‐km wavelength that correlates with rift length. This continental lithosphere up‐bend correlates with the scale of the rift, and appears maximum in the center of the rift, where drainage reversal of large catchments suggests rapid slip rates at the bounding fault. This is consistent with the growth of a new, rift‐scale, high‐angle normal fault. The coherency of elastic flexure in space and time implies highly localized strain in the rift‐bounding fault and suggests that the fault transects continental lithosphere with long‐term strength. The unparalleled record of flexural uplift and highly localized strain in the landscape of Corinth suggest these processes are intrinsic to early continental rifting elsewhere.
Role of Extreme Precipitation and Initial Hydrologic Conditions on Floods in Godavari River Basin, India
Authors: Garg Shailesh , Mishra Vimal 
Published: November 2019

AbstractFloods are the most frequent natural calamity in India. The Godavari river basin (GRB) witnessed several floods in the past 50 years. Notwithstanding the large damage and economic loss, the role of extreme precipitation and antecedent moisture conditions on floods in the GRB remains unexplored. Using the observations and the well‐calibrated Variable Infiltration Capacity model, we estimate the changes in the extreme precipitation and floods in the observed (1955–2016) and projected future (2071–2100) climate in the GRB. We evaluate the role of initial hydrologic conditions and extreme precipitation on floods in both observed and projected future climate. We find a statistically significant increase in annual maximum precipitation for the catchments upstream of four gage stations during the 1955–2016 period. However, the rise in annual maximum streamflow at all the four gage stations in GRB was not statistically significant. The probability of floods driven by extreme precipitation (PFEP) varies between 0.55 and 0.7 at the four gage stations of the GRB, which declines with the size of the basins. More than 80% of extreme precipitation events that cause floods occur on wet antecedent moisture conditions at all the four locations in the GRB. The frequency of extreme precipitation events is projected to rise by two folds or more (under RCP 8.5) in the future (2071–2100) at all four locations. However, the increased frequency of floods under the future climate will largely be driven by the substantial rise in the extreme precipitation events rather than wet antecedent moisture conditions.
Genetic analysis of stilbenoid profiles in grapevine stems reveals a major mQTL hotspot on chromosome 18 associated with disease-resistance motifs
Authors: Teh Soon L. , Rostandy Bety , Awale Mani , Luby James J. , Fennell Anne , Hegeman Adrian D. 
Published: November 2019

AbstractGrapevine (Vitisspp.) contains a wealth of phytochemicals that have received considerable attention due to health-promoting properties and biological activities as phytoalexins. To date, the genetic basis of the quantitative variations for these potentially beneficial compounds has been limited. Here, metabolic quantitative trait locus (mQTL) mapping was conducted using grapevine stems of a segregating F2population. Metabolic profiling of grapevine stems was performed using liquid chromatography–high-resolution mass spectrometry (LC-HRMS), resulting in the detection of 1317 ions/features. In total, 19 of these features matched with literature-reported stilbenoid masses and were genetically mapped using a 1449-SNP linkage map and R/qtl software, resulting in the identification of four mQTLs. Two large-effect mQTLs that corresponded to a stilbenoid dimer and a trimer were mapped on chromosome 18, accounting for phenotypic variances of 29.0% and 38.4%. Functional annotations of these large-effect mQTLs on the VitisNet network database revealed a major hotspot of disease-resistance motifs on chromosome 18. This 2.8-Mbp region contains 48 genes with R-gene motifs, including variants of TIR, NBS, and LRR, that might potentially confer resistance to powdery mildew, downy mildew, or other pathogens. The locus also encompasses genes associated with flavonoid and biosynthetic pathways that are likely involved in the production of secondary metabolites, including phytoalexins. In addition, haplotype dosage effects of the five mQTLs further characterized the genomic regions for differential production of stilbenoids that can be applied in resistance breeding through manipulation of stilbenoid production in planta.
Single microcolony diffusion analysis in Pseudomonas aeruginosa biofilms
Authors: Sankaran Jagadish , Tan Nicholas J. H. J. , But Ka Pui , Cohen Yehuda , Rice Scott A. , Wohland Thorsten 
Published: November 2019

AbstractThe influence of the biofilm matrix on molecular diffusion is commonly hypothesized to be responsible for emergent characteristics of biofilms such as nutrient trapping, signal accumulation and antibiotic tolerance. Hence quantifying the molecular diffusion coefficient is important to determine whether there is an influence of biofilm microenvironment on the mobility of molecules. Here, we use single plane illumination microscopy fluorescence correlation spectroscopy (SPIM-FCS) to obtain 3D diffusion coefficient maps with micrometre spatial and millisecond temporal resolution of entirePseudomonas aeruginosamicrocolonies. We probed how molecular properties such as size and charge as well as biofilm properties such as microcolony size and depth influence diffusion of fluorescently labelled dextrans inside biofilms. The 2 MDa dextran showed uneven penetration and a reduction in diffusion coefficient suggesting that the biofilm acts as a molecular sieve. Its diffusion coefficient was negatively correlated with the size of the microcolony. Positively charged dextran molecules and positively charged antibiotic tobramycin preferentially partitioned into the biofilm and remained mobile inside the microcolony, albeit with a reduced diffusion coefficient. Lastly, we measured changes of diffusion upon induction of dispersal and detected an increase in diffusion coefficient inside the biofilm before any loss of biomass. Thus, the change in diffusion is a proxy to detect early stages of dispersal. Our work shows that 3D diffusion maps are very sensitive to physiological changes in biofilms, viz. dispersal. However, this study also shows that diffusion, as mediated by the biofilm matrix, does not account for the high level of antibiotic tolerance associated with biofilms.
Experimentally attacking quantum money schemes based on quantum retrieval games
Authors: Jiráková Kateřina , Bartkiewicz Karol , Černoch Antonín , Lemr Karel 
Published: November 2019

AbstractThe concept of quantum money (QM) was proposed by Wiesner in the 1970s. Its main advantage is that every attempt to copy QM unavoidably leads to imperfect counterfeits. In the Wiesner’s protocol, quantum banknotes need to be delivered to the issuing bank for verification. Thus, QM requires quantum communication which range is limited by noise and losses. Recently, Bozzio et al. (2018) have demonstrated experimentally how to replace challenging quantum verification with a classical channel and a quantum retrieval game (QRG). This brings QM significantly closer to practical realisation, but still thorough analysis of the revised scheme QM is required before it can be considered secure. We address this problem by presenting a proof-of-concept attack on QRG-based QM schemes, where we show that even imperfect quantum cloning can, under some circumstances, provide enough information to break a QRG-based QM scheme.
Neurophysiological evidence for rapid processing of verbal and gestural information in understanding communicative actions
Authors: Tomasello Rosario , Kim Cora , Dreyer Felix R. , Grisoni Luigi , Pulvermüller Friedemann 
Published: November 2019

AbstractDuring everyday social interaction, gestures are a fundamental part of human communication. The communicative pragmatic role of hand gestures and their interaction with spoken language has been documented at the earliest stage of language development, in which two types of indexical gestures are most prominent: thepointinggesture for directing attention to objects and thegive-megesture for making requests. Here we study, in adult human participants, the neurophysiological signatures of gestural-linguistic acts of communicating the pragmatic intentions of naming and requesting by simultaneously presenting written words and gestures. Already at ~150 ms, brain responses diverged between naming and request actions expressed by word-gesture combination, whereas the same gestures presented in isolation elicited their earliest neurophysiological dissociations significantly later (at ~210 ms). There was an early enhancement of request-evoked brain activity as compared with naming, which was due to sources in the frontocentral cortex, consistent with access to action knowledge in request understanding. In addition, an enhanced N400-like response indicated late semantic integration of gesture-language interaction. The present study demonstrates that word-gesture combinations used to express communicative pragmatic intentions speed up the brain correlates of comprehension processes – compared with gesture-only understanding – thereby calling into question current serial linguistic models viewing pragmatic function decoding at the end of a language comprehension cascade. Instead, information about the social-interactive role of communicative acts is processed instantaneously.
Emerging WS2/montmorillonite composite nanosheets as an efficient hydrophilic photocatalyst for aqueous phase reactions
Authors: Peng Kang , Wang Hongjie , Li Xiaoyu , Wang Jianwei , Cai Zhixin , Su Lei , Fan Xingyu 
Published: November 2019

AbstractTungsten disulfide (WS2) as one of transition metal dichalcogenides exhibits excellent catalytic activity. However, its catalytic performances in aqueous phase reactions are limited by its hydrophobicity. Here, the natural hydrophilic two-dimensional clay was used to enhance the dispersibility of WS2 in aqueous phase. WS2/montmorillonite (WS2/MMT) composite nanosheets were prepared via hydrothermal synthesis of WS2 on the surface of montmorillonite from WCl6 and CH3CSNH2. The microstructure and morphology show that WS2 nanosheets are assembled parallelly on the montmorillonite with the interface interaction. Through the support of montmorillonite, WS2/MMT possesses higher photocatalytic ability for aqueous phase reactions than WS2, which could be due to the synergistic effect of higher adsorption property, higher hydrophilicity, dispersibility and more catalytic reaction site. The strategy could provide new ideas for obtaining novel hydrophilic photocatalyst with excellent performance.
Creating artificial Rhino Horns from Horse Hair
Authors: Mi Ruixin , Shao Z. Z. , Vollrath F. 
Published: November 2019

AbstractDemand for rhino horn is driving poaching with devastating effect for the few individuals left of the few species surviving from this once numerous, widespread and cosmopolitan clade of pachyderms. We bundled together tail hairs of the rhino’s ubiquitous near relative, the horse, to be glued together with a bespoke matrix of regenerated silk mimicking the collagenous component of the real horn. This approach allowed us to fabricate composite structures that were confusingly similar to real rhino horn in look, feel and properties. Spectral and thermal FT-IR, DSC and TGA analysis demonstrated the similar chemical composition and thermo-mechanical properties between the natural and the faux horns.
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Authors: Nygård Ståle , Lingjærde Ole Christian , Caldas Carlos , Hovig Eivind , Børresen-Dale Anne-Lise , Helland Åslaug , Haakensen Vilde D. 
Published: November 2019

AbstractGene expression profiling of tumours is an important source of information for cancer patient stratification. Detecting subtle alterations of gene expression remains a challenge, however. Here, we propose a novel tool for high-sensitivity detection of differential pathway activity in tumours. For a pathway defined by a collection of genes, the samples are projected onto a low-dimensional manifold in the subspace spanned by those genes. For each sample, a score is next found by calculating the distance between each projected sample and the projection of a subgroup of reference samples. Depending on the aim of the analysis and the available data, the reference samples may represent e.g. normal tissue or tumour samples with a particular genotype or phenotype. The proposed tool, PathTracer, is demonstrated on gene expression data from 1952 invasive breast cancer samples, 10 DCIS, 9 benign samples and 144 tumour adjacent normal breast tissue samples. PathTracer scores are shown to predict survival, clinical subtypes, cellular proliferation and genomic instability. Furthermore, predictions are shown to outperform those obtained with other comparable methods.
Amino acid substitution scoring matrices specific to intrinsically disordered regions in proteins
Authors: Trivedi Rakesh , Nagarajaram Hampapathalu Adimurthy 
Published: November 2019

AbstractAn amino acid substitution scoring matrix encapsulates the rates at which various amino acid residues in proteins are substituted by other amino acid residues, over time. Database search methods make use of substitution scoring matrices to identify sequences with homologous relationships. However, widely used substitution scoring matrices, such as BLOSUM series, have been developed using aligned blocks that are mostly devoid of disordered regions in proteins. Hence, these substitution-scoring matrices are mostly inappropriate for homology searches involving proteins enriched with disordered regions as the disordered regions have distinct amino acid compositional bias, and therefore expected to have undergone amino acid substitutions that are distinct from those in the ordered regions. We, therefore, developed a novel series of substitution scoring matrices referred to as EDSSMat by exclusively considering the substitution frequencies of amino acids in the disordered regions of the eukaryotic proteins. The newly developed matrices were tested for their ability to detect homologs of proteins enriched with disordered regions by means of SSEARCH tool. The results unequivocally demonstrate that EDSSMat matrices detect more number of homologs than the widely used BLOSUM, PAM and other standard matrices, indicating their utility value for homology searches of intrinsically disordered proteins.
Preparation of RGO/TiO2/Ag Aerogel and Its Photodegradation Performance in Gas Phase Formaldehyde
Authors: Wang Haiwang , Wang Guanqi , Zhang Yukai , Ma Yuan , Wu Zhengjie , Gao Dekuan , Yang Rutong , Wang Bingzhu , Qi Xiwei , Yang Jun 
Published: November 2019

AbstractTo increase the utilization ratio and catalytic efficiency of the nano TiO2, The RGO/TiO2/(Ag) powders and RGO/TiO2/Ag aerogel photocatalyst were designed and prepared. The composition and microstructure of RGO/TiO2/(Ag) powders and RGO/TiO2/Ag aerogel were studied, in addition, the photocatalytic activity of RGO/TiO2/(Ag) powders and RGO/TiO2/Ag aerogel was researched by the photocatalytic degradation behavior of formaldehyde solution and formaldehyde gas respectively. The result indicate that TiO2 is uniformly loaded on the surface of RGO with a particle size of 10 nm to 20 nm. When the amount of graphene oxide added is 1 wt%, RGO/TiO2 powder has the highest degradation effect on formaldehyde solution, in addition, the introduction of Ag can greatly improve the photocatalytic effect of the sample. The results also show that the pore size of RGO/TiO2/Ag aerogel is between 7.6 nm and 12.1 nm, and the degradation rate of formaldehyde gas is 77.08% within 2 hours.
Enhanced immobilization of Prussian blue through hydrogel formation by polymerization of acrylic acid for radioactive cesium adsorption
Authors: Oh Daemin , Kim Bokseong , Kang Sungwon , Kim Youngsug , Yoo Sungjong , Kim Sol , Chung Yoonshun , Choung Sungwook , Han Jeonghee , Jung Sunghee , Kim Hyowon , Hwang Yuhoon 
Published: November 2019

AbstractIn this study, a hydrogel impregnated with powder activated carbon (PAC), MAA-PAC, was synthesized through the polymerization of acrylic acid (AA) and PB was immobilized using the carboxyl group of AA. In this process, an adsorbent with an enhancement of PB content and stability of immobilization was developed through the additional supply of Fe3+ ions by the layer by layer (LBL) assembly. XRD, FT-IR, SEM (EDS), TEM (EDS, mapping), and TG analyzes of the LBL and non-LBL groups were performed to confirm the change of PB content in the adsorbent as the LBL assembly was applied. The stability of PB immobilization was confirmed during the washing process after the synthesis of the adsorbent. When the LBL assembly process was applied as a PB immobilization strategy, the PB content in the adsorbent was improved and PB leakage was not observed during the washing process. The maximum adsorption (qm) for cesium in the MAA-PAC-PB LBL group that showed high PB content was 40.03 mg/g, and the adsorption isotherm was more suitable for the Langmuir model than the Freundlich model. The LBL group showed a high removal efficiency of 99.81% and a high DF value (525.88) for radioactive cesium (120 Bq/g). These results demonstrate the potential efficiency of the MAA-PAC-PB LBL group for the decontamination of radioactive cesium-contaminated water systems. Furthermore, it was verified that the LBL group of MAA-PAC-PB could be used as an adsorbent without an additional design of the existing water treatment facility. This can an economical decontamination method for removing radioactive cesium.
Assessment of residents’ total environmental exposure to heavy metals in China
Authors: Zhao Xiuge , Li Zhenglei , Wang Danlu , Li Ji , Zou Bin , Tao Yan , Lei Limin , Qiao Feiyang , Huang Ju 
Published: November 2019

AbstractHeavy metal pollution in the air, water, and soil has attracted substantial interest recently; however, assessment of the total human environmental exposure remains limited. Therefore, determining the total human environmental exposure is imperative for the management and control of heavy metal pollution. This study assessed the total environmental exposure levels of heavy metals as well as the exposure contributions of air, water, and soil, focusing on Hg, Cd, As, Pb, and Cr. Data from 3,855 volunteers from the cities of Taiyuan, Dalian, Shanghai, Wuhan, Chengdu, and Lanzhou allowed for comparison of the exposures in urban and rural areas. The levels of total human environmental exposure of Hg, Cd, As, Pb, and Cr were 1.82 × 10−6 mg/(kg·d), 1.58 × 10−6 mg/(kg·d), 3.87 × 10−5 mg/(kg·d), 1.79 × 10−5 and 7.47 × 10−5 mg/(kg·d), respectively. There were regional, urban-rural, sex, and age differences in the levels of heavy metal exposure. Water pollution was determined to be the largest contributor to heavy metal exposure, accounting for 97.87%, 92.50%, 80.51%, 76.16% and 79.46% of the Hg, Cd, As, Pb, and Cr, followed by air and soil pollution. These results can provide data to inform environmental protection policies and identify the priority pollutants that can help identify and prevent health risks due to overexposure to these heavy metal pollutants.
Regional Patterns in Retinal Microvascular Network Geometry in Health and Disease
Authors: Popovic Natasa , Vujosevic Stela , Popovic Tomo 
Published: November 2019

AbstractThe study explores the regional differences in microvascular geometry between the optic disc (O) and the macular area (M) in health and disease. Skeletonized manually segmented vascular networks from 15 healthy, 15 retinas with diabetic retinopathy (DR), and 15 retinas with glaucoma from publicly available High-Resolution Fundus (HRF) image database were used. When visualized by a digital fundus camera, O has a substantial proportion of small arteries and larger arterioles, while M contains smaller arterioles at the periphery and avascular zone in the center. We hypothesized that in pathological conditions the vascular network remodelling patterns in these two regions may be different. The analysis of box-counting fractal dimension (Db), lacunarity (Λ), and microvascular density showed that in healthy retinas, Λ and vessel density were lower in the M compared to the O, while the Db did not change. In retinas with DR, the Db was the lowest in the M, which was different from all other groups. The vessel density followed this trend. Lacunarity was the highest in the O of DR group compared to all other groups. The results show that in DR various regions of retinal microvascular network remodel in a different manner and to different extent.
Neutrophil extracellular traps and monocyte subsets at the culprit lesion site of myocardial infarction patients
Authors: Mangold Andreas , Hofbauer Thomas M. , Ondracek Anna S. , Artner Tyler , Scherz Thomas , Speidl Walter S. , Krychtiuk Konstantin A. , Sadushi-Kolici Roela , Jakowitsch Johannes , Lang Irene M. 
Published: November 2019

AbstractNeutrophils release their chromatin into the extracellular space upon activation. These web-like structures are called neutrophil extracellular traps (NETs) and have potent prothrombotic and proinflammatory properties. In ST-elevation myocardial infarction (STEMI), NETs correlate with increased infarct size. The interplay of neutrophils and monocytes impacts cardiac remodeling. Monocyte subsets are classified as classical, intermediate and non-classical monocytes. In the present study, in vitro stimulation with NETs led to an increase of intermediate monocytes and reduced expression of CX3CR1 in all subsets. Intermediate monocytes have been associated with poor outcome, while non-classical CX3CR1-positive monocytes could have reparative function after STEMI. We characterized monocyte subsets and NET markers at the culprit lesion site of STEMI patients (n = 91). NET surrogate markers were increased and correlated with larger infarct size and with fewer non-classical monocytes. Intermediate and especially non-classical monocytes were increased at the culprit site compared to the femoral site. Low CX3CR1 expression of monocytes correlated with high NET markers and increased infarct size. In this translational system, causality cannot be proven. However, our data suggest that NETs interfere with monocytic differentiation and receptor expression, presumably promoting a subset shift at the culprit lesion site. Reduced monocyte CX3CR1 expression may compromise myocardial salvage.