bluuebunny/crossref_metadata_2025_split huggingface dataset:
Donor Designation Among Mature Latinas and Lay Health Educators (Promotoras): A Mixed-Methods Study
Authors: Gordon Elisa J. , Gardiner Heather , Siminoff Laura A. , Kelly Patrick J. , Agu Chidera , Urbanski Megan , Alolod Gerard P. , Benitez Amanda , Hernandez Ilda , Guinansaca Nancy , Ramos Winther Lori , Bergeron Caroline D. , Kim Rachel , Montalvo Antonette , Gonzalez Tony 
Published: December 2020

Background Despite positive public attitudes toward solid organ donation in the United States, some of the lowest rates of donor designation persist among older adults and Latinx populations. Aims To identify barriers and facilitators to organ donation and donor designation among lay health educators ( promotoras) and mature Latina (50+ years). Methods An explanatory sequential mixed-method design was employed, with telephone surveys followed by focus group interviews, to assess and understand the nuances of organ donation and donor designation knowledge, attitudes, and practices among promotoras and mature Latinas in Chicago (IL), Philadelphia (PA), and San Antonio (TX). Descriptive statistics summarized quantitative survey data; thematic content analysis was performed on qualitative data. Results Twenty-nine promotoras and 45 mature Latina participated in both the surveys and focus groups ( N = 74). Most participants (90%) had limited knowledge of organ donation but reported being “somewhat” or “strongly” in favor of donation (70%); 40.5% were registered donors. Participants lacked knowledge about the registration process and its legal standing and upheld concerns that registered donors would be vulnerable to organ traffickers or targets for murder. Themes emerging from the group interviews revealed additional barriers to designation including distrust of the medical establishment, perceptions of inequities in organ allocation, and family resistance to discussing death. Discussion Low donor designation rates are primarily driven by concerns about organ trafficking and the fairness of the allocation system, particularly for undocumented immigrants. Conclusions The results informed development of a culturally targeted educational and communication skills intervention to increase donor designation in Latinx communities. Trial registration ClinicalTrials.gov NCT04007419.
Proposal for the management of myopic traction maculopathy based on the new MTM staging system
Authors: Parolini Barbara , Palmieri Michele , Finzi Alessandro , Frisina Rino 
Published: December 2020

Purpose: To propose the Myopic Traction Maculopathy (MTM) management Table, based on the MTM Staging System (MSS). Methods: A retrospective review of 157 eyes affected by MTM, operated with pars plana vitrectomy (PPV), or macular buckle (MB) or combined surgery (MB + PPV). Each case was classified according to the MSS. Anatomical results were evaluated with OCT at an intermediate follow-up (3–6 months) and at a final follow-up (2–8 years), considering changes both in the foveal and in the retinal pattern. The number and type of operations needed were noted. The surgical complications were reported. Results: Primary surgery was MB for 83 eyes (52%), PPV for 36 (23%) and MB + PPV for 38 (24%). At intermediate follow-up, the retinal pattern was restored in 55.41% and foveal in 42.68%. Further surgery was indicated as PPV in 25.48%, MB in 14.65%. At the final follow-up, the retinal pattern was restored in 96.16% and the foveal pattern in 87.90%. BCVA improved at the final follow-up ( p < 0.05). The complications of MB were not sight-threatening. The complications of PPV were FTMH in 67% cases in stages 2, 3, and 4. Cataract developed in 60% of phakic eyes. The complications of combined MB+PPV were cataract (56%) and PVR (5%). Conclusions: Both PPV and MB may be used to treat MTM. PPV addresses the changes in the foveal pattern while MB addresses the changes in the retinal pattern. The MTM management table offers a proposal for the choice of type and timing of treatment customized per each stage of MTM.
Prevalence of Mental Health Disorders among Individuals Enrolled in an Emergency Response Program for Treatment of Opioid Use Disorder
Authors: Bakos-Block Christine , Langabeer James R , Yatsco Andrea , Cardenas-Turanzas Marylou , Champagne-Langabeer Tiffany 
Published: December 2020

Background: Psychiatric co-occurring disorders among individuals with opioid use disorder has primarily focused on epidemiological surveys of patients in continuous or long-term treatment, yet little is known about the socio-economically vulnerable who are non-treatment seeking prior to an emergency response. Methods: We retrospectively analyzed data from patients who had enrolled in a study involving home outreach to patients referred from police, emergency medical services (EMS), or hospital emergency departments following an emergency response. The sample is largely socio-economically vulnerable with high rates of unemployment and uninsured. Eligible consenting patients received an intervention consisting of medication (buprenorphine), behavioral counseling, and peer support. Participants completed semi-structured, psychological instruments to assess current and prior history for both substance use and mental health disorders. We used descriptive statistics to evaluate rates of co-occurring mental health comorbidity. Results: Among 102 patients (average age = 36.5 years old), approximately 61 (59.8%) reported a prior mental health diagnosis, with 31 (30.3%) currently on medications for their diagnoses. Mood and anxiety disorders were most frequently recorded. Just over half (51%) had received any prior treatment for their substance use. Of those with dual disorders, 67.2% had experienced prior suicidal thoughts, and 63.7% reported polysubstance use of 5 or more substances. Conclusion: Co-occurring psychiatric disorders, and specifically mood and anxiety disorders, appear to be prevalent in vulnerable populations at an increased rate. Mental health assessments should routinely be performed in the emergency setting and in early stages of treatment.
Predictors of Adherence Toward Specific Domains of Diabetic Self-Care Among Type-2 Diabetes Patients
Authors: Degefa Girma , Wubshet Kindie , Tesfaye Sisay , Hirigo Agete Tadewos 
Published: December 2020

Background:Adequate knowledge, awareness, and adherence to diabetic self-care practices are vital tools to protect patients from risks of disease complications, developing comorbidity and mortality. Therefore, this study aimed to assess specific domains of diabetic self-care practice and associated factors among patients with type-2diabetes in Hawassa University Comprehensive Specialized Hospital, Sidama regional state.Materials and methods:A hospital-based cross-sectional study design was conducted on 217 patients with type 2 diabetes from January 01 to April 30, 2020. A structured questionnaire and the Summary of Diabetes Self-Care Activities (SDSCA) tool were used to collect relevant data through interviewer administration. Statistical analysis was done using SPSS version 23.Results:A total of 207 patients with type-2 diabetes were participated in the study with a 95% response rate. Overall 47.8% (95%CI: 41.2-55) of patients adhered to diabetic self-care practice. Concerning the specific domain of self-care practice, 54.6%, 39.1%, 28%, and 65.2% of patients adhered to a healthy diet, physical exercise, self-monitoring blood glucose (SMBG), and diabetic foot care practices, respectively. Besides, all patients received at least 80% of the prescribed doses and frequency of anti-diabetic agents and 60.4% had good glycemic control. Receipt of advice from treating physicians and having no familial history of diabetes were significantly associated with adherence toward eating a healthy diet, diabetic foot care, and SMBG. While male sex was associated with adherence toward healthy diet management. Moreover, having glucometer, age, male sex, diabetes duration ⩾ 5 years, and anti-diabetic treatment modality were associated with adherence toward SMBG.Conclusion:This study indicates 52.2%, 72%, and 60.1% of diabetes patients did not adhere to diabetic self-care, SMBG, and physical exercise, respectively. Improving awareness and regular diabetic education is imperative to scale up patients’ adherence toward diabetic self-care practice.
Adapting existing behaviour: Perceptions of substance switching and implementation of minimum pricing for alcohol in Wales
Authors: Livingston Wulf , Holloway Katy , May Tom , Buhociu Marian , Madoc-Jones Iolo , Perkins Andy 
Published: December 2020

Aim: Minimum Pricing for Alcohol (MPA) was enacted in Wales on March 2nd 2020. During the legislative process (i.e. consultation and parliamentary discussion), concern was expressed about the possibility of some drinkers switching to using other substances in response to any rise in the cost of alcohol. This paper reports on findings from a study which explored these pre-implementation concerns and how the policy was shaped. Method: The research involved surveys (n=193) and interviews (n=87) with drinkers (predominantly harmful or treatment seeking) and providers of services. Survey responses were detailed, thus when combined with the interviews, provided a wealth of qualitative data, which are drawn upon in this paper. Results: The findings highlight an expectation that most drinkers would respond to the new policy with adaptations of their coping mechanisms to maintain alcohol use at pre-legislative levels. This was either by switching alcohol products and adjusting their lifestyle to maintain an affordable drinking habit or developing new behaviours to manage additional costs. A small group of those with previous experience of drug use were identified as likely to switch from using alcohol to some other substances. Conclusions: Prior to the legislation being implemented awareness of the detail of the policy was found to be low, and the perceptions of increased potential harm for certain groups, including switching, were linked to concern about a lack of treatment capacity.
Prospective multicentre mid-term clinical and radiological outcomes of 159 reverse total shoulder replacements and assessment of the influence of post-operative complications
Authors: Imam Mohamed A , Neumann Jörg , Siebert Werner , Mai Sabine , Verborgt Olivier , Eckers Franziska , Jacobs Leo , Meyer Dominik C 
Published: December 2020

Background The aim of our prospective multicentre study is to evaluate the five-year follow-up outcomes of primary reverse shoulder replacement utilizing two different designs of glenoid baseplates. Methods There were 159 reverse shoulder replacements (91 cemented and 68 uncemented stems, 67 Trabecular Metal baseplates and 92 Anatomical Shoulder baseplates in 152 patients (99 women) with a mean age of 74.5 (58–90) years. The principal diagnosis was rotator cuff arthropathy in 108 shoulders. Results Clinical and functional results improved significantly overall; the adjusted Constant Murley score improved from 28.2 ± 13.3 pre-operatively to 75.5 ± 22.8 ( p < 0.0001) and the mean Subjective Shoulder Value improved from 27.5 ± 20 to 73.8 ± 21.3 points ( p < 0.0001). Radiologically, there was good bony stability in 88% and 86% of cemented and uncemented stems without significant impact on the Constant Murley score and Subjective Shoulder Value at one, two and five years post-surgery. There were no significant clinical differences between Trabecular Metal and Anatomical Shoulder baseplates at five years. There were four cases of intraoperative shaft fractures that were managed with cables. Although the Trabecular Metal baseplates showed better integration radiologically, there was no significant difference in the mean of Constant Murley, Subjective Shoulder Value and the range of motion depending on the grade of inferior scapular notching at one-, two- and five-year intervals. Conclusions Reverse total shoulder arthroplasty restores the function in shoulder with significant improvements in function and moderate complications with minor differences between both designs of baseplates that were not reflected clinically.
Incorporating 3D Printing Into Your Practice: Lessons Learned
Authors: Sharma Akhil , Kirkland Kyle S. , Holloway Robert M. , Parekh Selene G. 
Published: December 2020

Three-dimensional (3D) printing has greatly benefited medicine, manufacturing vital organs like skin, hearts, kidneys, and livers. Early studies on 3D printing in surgery have consistently reported decreased operative time and improved precision. This technology has gained popularity with orthopaedic surgeons in knee, hip, and shoulder surgeries because 3D printing is associated with enhancing osseointegration. However, this innovation is still not commonly used among foot and ankle surgeons; one reason is that whereas the literature on 3D printing–assisted surgery is populated with studies on operative techniques and clinical outcomes, there exists an ambiguity on how to incorporate this feature into the clinic. Thus, the aim of this technology column is to consolidate and standardize a workflow to guide foot and ankle surgeons on integrating 3D printing into one’s practice. We describe a model developed by a single surgeon at one institution who directs a large caseload of 3D-printed foot and ankle surgeries. From the initial patient visit to the interaction between the surgeon and the implant engineering team, to documentation of data adding to the preliminary literature, this work has great implications on streamlining the assimilation of a highly successful technology to improve foot and ankle surgery for both surgeons and patients. Level of Evidence: Level V
Salvage Tibiotalocalcaneal Arthrodesis Augmented With Fibular Columns and Iliac Crest Autograft: A Technical Note
Authors: Bernasconi Alessio , Patel Shelain , Malhotra Karan , Singh Dishan , Welck Matthew , Cullen Nicholas 
Published: December 2020

Failure of ankle arthrodesis or total ankle replacement (TAR) results in a challenging clinical situation and may take the form of symptomatic nonunion following arthrodesis and aseptic or infective loosening following TAR. Revision in these scenarios is technically demanding, and if associated with subtalar degeneration, conversion to tibiotalocalcaneal (TTC) arthrodesis may be required, with use of bone grafting to maintain length and reduce disability. Fibular strut grafting in the form of pillars or columns, potentially supplemented by tricortical and iliac graft, may be used in association with intramedullary TTC nailing or lateral plating and has demonstrated encouraging fusion rates. In this technical note, we review the history of this technique and report indications and surgical approach. Furthermore, of 6 cases (mean age 69.8 years) treated at our institution and followed at 13 months (range, 8 to 20 months), 5 (83%) were clinically and radiologically united, and patients were satisfied with the outcome of surgery. One patient with a background of chronic kidney disease remained dissatisfied with no union achieved, persistent pain, and awaiting a below-the-knee amputation. No other complications were observed. TTC fusion augmented with fibular columns and iliac crest autograft is an option to treat combined ankle and subtalar joint pathologies with significant talar bone loss. Levels of Evidence: Level V (technical note)
User Factors Affecting Both Subscription Intention and Time for 4G Wireless Internet Service
Authors: Lee Sangjae , Kim Byung Gon 
Published: December 2020

While much attention is paid to 4G wireless Internet service based on long term evolution (LTE) technology, the previous studies investigating both subscription intention and of 4G wireless Internet service time are lacking. This study attempts to fill this void by analyzing the subscription intention and time of 4G wireless Internet service users using a bivariate two-equation model. Further, as previous studies on self-efficacy and innovativeness are lacking in mobile service adoption despite the importance of user capability for adopting Internet service, this study intends to fill the void by including user technical competency representing possession of comprehensive knowledge for 4G wireless Internet service, extensive use of wireless Internet, and the use of advanced smart phone. The analysis results of bivariate two-equation model using the sample of 810 Korean users show that if users have the comprehensive knowledge for 4G wireless service, or use advanced mobile smart phone, or greatly use wireless Internet through advanced mobile smart phone, or who are male they are more likely to adopt 4G wireless service. The subscription time is shorter for the users who extensively use wireless Internet and use advanced mobile smart phone or, are male, and have high before tax monthly income. This study contributes to literature in mobile services by suggesting user technical competency as affecting subscription intention and time for 4G wireless Internet service. Managers may better concentrate their marketing efforts to the group of people using wireless Internet extensively and advanced mobile smart phone, and who are male.
Comparison of Marginal Adaptation of Different Resin-Ceramic CAD/CAM Crowns: An In Vitro Study
Authors: Oguz Ece Irem , Kılıçarslan Mehmet Ali , Özgür Merve Erdog˘ , Orhan Kaan , Shujaat Sohaib 
Published: December 2020

Aim: To compare the marginal adaptation of crowns fabricated by using three different resin-ceramic computer-aided design/computer-aided manufacturing (CAD/CAM) materials. Materials and Methods: Crowns fabricated from three different resin-ceramic CAD/CAM blocks, applied on a typodont premolar (#14), were tested with regard to marginal adaptation, in this in vitro study. The typodont maxillary first premolar was prepared to serve as the master die and digitized with an intraoral scanner. The same virtual crown design was used to fabricate all specimens. Forty-eight crowns were fabricated from the same virtual crown design using three different CAD/CAM resin-ceramic blocks as follows ( n = 16): Lava Ultimate (LU), GC Cerasmart (GC), Vita Enamic (VE). Master die and crowns were scanned with a laboratory scanner and three-dimensional data were transferred into three-matic software. The software calculated the mean of the marginal discrepancy (MD) for each crown in negative and positive values, representing under and over estimation of the crown margin, respectively. A marginal discrepancy index (MDI) was obtained for each group using negative and positive MDs. All data were statistically analyzed using one-way analysis of variance and Tukey’s honest significance test ( α = 0.05). Results: The analysis of variance showed no statistical differences between materials regarding the negative and positive MDs ( P > .05). The MDI for LU was lower than GC and VE ( P < .05). Conclusion: The marginal adaptation of different resin-ceramic materials was different with regard to MDI values. Nevertheless, the MD values of all groups were within the clinically acceptable range.
Safety of Anticoagulation in Patients With an Intracranial Hemorrhage at a Comprehensive Stroke Center
Authors: Boyko Sarah F. , Morgan Olivia , Shah Kruti , Chester Katleen 
Published: December 2020

Background: Approximately 10% to 15% of patients who suffer intracranial hemorrhages (ICHs) are on therapeutic anticoagulation. Additionally, patients may develop an indication for anticoagulation after ICH. There is minimal guidance with starting anticoagulation after an ICH, and most evidence has evaluated vitamin K antagonists (VKA). Objective: The aim of this study was to evaluate the safety of anticoagulation prescribing following a nontraumatic ICH with VKA, low molecular weight heparin (LMWH), or direct oral anticoagulants (DOACs). Methods: A retrospective chart review was conducted of patients admitted with a nontraumatic ICH and an indication for anticoagulation between February 2015 to June 2018 at an urban tertiary comprehensive stroke center. The primary objective was to evaluate the safety of prescribing anticoagulation in these patients. Two groups were reviewed to evaluate the primary outcome: patients who were started on anticoagulation after ICH (anticoagulation group) and a comparator group not started on anticoagulation (control group). The primary endpoint was measured by a composite incidence of recurrent ICH, major bleeding events, and thromboembolic events. Results: Anticoagulation was started within 2 months in 23 patients with an indication for anticoagulation. Anticoagulation was held in 35 patients. There was no difference in the composite primary endpoint between the 2 groups ( P = .29). The median time to starting anticoagulation was 21 days (IQR 7-28 days). Conclusions: This study shows the safety of starting anticoagulation in patients with recent ICH in our cohort of patients and highlights the need for more robust evidence to guide clinical decision making.
ARPIR: automatic RNA-Seq pipelines with interactive report
Authors: Spinozzi Giulio , Tini Valentina , Adorni Alessia , Falini Brunangelo , Martelli Maria Paola 
Published: December 2020

Abstract
Background
RNA-Seq is an increasing used methodology to study either coding and non-coding RNA expression. There are many software tools available for each phase of the RNA-Seq analysis and each of them uses different algorithms. Furthermore, the analysis consists of several steps regarding alignment (primary-analysis), quantification, differential analysis (secondary-analysis) and any tertiary-analysis and can therefore be time-consuming to deal with each step separately, in addition to requiring a computer knowledge. For this reason, the development of an automated pipeline that allows the entire analysis to be managed through a single initial command and that is easy to use even for those without computer skills can be useful. Faced with the vast availability of RNA-Seq analysis tools, it is first of all necessary to select a limited number of pipelines to include. For this purpose, we compared eight pipelines obtained by combining the most used tools and for each one we evaluated peak of RAM, time, sensitivity and specificity.

Results
The pipeline with shorter times, lower consumption of RAM and higher sensitivity is the one consisting in HISAT2 for alignment, featureCounts for quantification and edgeR for differential analysis. Here, we developed ARPIR, an automated pipeline that recurs by default to the cited pipeline, but it also allows to choose, between different tools, those of the pipelines having the best performances.

Conclusions
ARPIR allows the analysis of RNA-Seq data from groups undergoing different treatment allowing multiple comparisons in a single launch and can be used either for paired-end or single-end analysis. All the required prerequisites can be installed via a configuration script and the analysis can be launched via a graphical interface or by a template script. In addition, ARPIR makes a final tertiary-analysis that includes a Gene Ontology and Pathway analysis. The results can be viewed in an interactive Shiny App and exported in a report (pdf, word or html formats). ARPIR is an efficient and easy-to-use tool for RNA-Seq analysis from quality control to Pathway analysis that allows you to choose between different pipelines.