bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘It has candy. You need to press on it’: young adults’ perceptions of flavoured cigarettes in the Philippines
Authors: Brown Jennifer , Zhu Meng , Moran Meghan , Hoe Connie , Frejas Ferdie , Cohen Joanna E 
Published: May 2020

BackgroundThe Philippines has a high smoking prevalence and one of the largest tobacco menthol market shares in the world. Flavour capsule cigarettes were introduced to the Philippines in 2013, most of which are menthol flavoured, and their market share is increasing. We explored perceptions of flavoured cigarette packaging among young adult Filipinos.MethodsWe conducted eight focus groups with 63 young adults ages 18–24 years in Manila in 2019, stratified by gender and smoking status. We conducted a thematic analysis of the transcripts.ResultsMost participants assessed relative harm of cigarettes based on strength, mainly determined by colour of the packaging. Menthol cigarettes with primarily blue packaging were considered less harmful than menthol cigarettes with primarily green packaging. Many participants considered flavour capsule packs most attractive, compared with non-flavoured and traditional menthol cigarettes, due to the colouring of the packs and expectations regarding taste. Some participants likened the capsules and the taste of flavour capsule cigarettes to candy, and many participants thought flavour capsule cigarettes would most likely be smoked by teenagers or young adults.ConclusionsYoung adult Filipinos believe that some menthol-flavoured cigarettes are less harmful than other flavoured cigarettes and non-flavoured cigarettes and find flavour capsule cigarettes attractive. A tobacco flavour ban and implementation of plain packaging might help reduce misperceptions of risk and make cigarettes less appealing.
Age-, sex-, and region-specific differences in skeletal muscle size and quality
Authors: Stock Matt S. , Oranchuk Dustin J. , Burton Adam M. , Phan David C. 
Published: May 2020

Ultrasonography-derived cross-sectional area (CSA) and echo intensity (EI) are increasingly utilized by investigators to study muscle size and quality, respectively. We sought to examine age, sex, and region (proximal, middle, distal) differences in vastus lateralis and rectus femoris CSA and EI, and determine whether correction for subcutaneous fat thickness influences the magnitude of EI differences. Fifteen younger men (mean age = 23 years), 15 younger women (aged 21 years), 11 older men (aged 74 years), and 15 older women (aged 70 years) participated. Clear differences were observed among age, sex, and region for vastus lateralis CSA (p ≤ 0.013, d = 0.38–0.73), whereas rectus femoris CSA was only different between younger and older participants at the proximal region (p = 0.017, d = 0.65). Uncorrected EI was greatest at the distal region of both muscles (p < 0.001, d = 0.59–1.38), with only the younger men having significantly lower EI values than the other groups (p ≤ 0.043, d = 0.37–0.63). Subcutaneous fat correction resulted in a marked increase in the magnitude of sex-specific EI differences (p ≤ 0.032, d ≥ 0.42). Additionally, subcutaneous fat correction increased the uniformity of EI throughout the thigh. These findings highlight considerable region-specific differences in muscle size and quality among younger and older men and women and highlight the need to correct for subcutaneous fat thickness when examining EI. Novelty Rectus femoris CSA is similar between younger and older adults except at the most proximal site evaluated. Age- and sex-specific differences in uncorrected EI are nonuniform across the thigh. Correction for subcutaneous fat thickness substantially increased EI in women, resulting in greater sex differences.
Using the Long Wavelength Array to Search for Cosmic Dawn
Authors: DiLullo Christopher , Taylor Gregory B. , Dowell Jayce 
Published: May 2020

The search for the spectral signature of hydrogen from the formation of the first stars, known as Cosmic Dawn or First Light, is an ongoing effort around the world. The signature should present itself as a decrease in the temperature of the 21[Formula: see text]cm transition relative to that of the Cosmic Microwave Background and is believed to reside somewhere below 100[Formula: see text]MHz. A potential detection was published by the Experiment to Detect the Global EoR Signal (EDGES) collaboration with a profile centered around 78[Formula: see text]MHz of both unexpected depth and width (Bowman et al. [2018] Nature 555, 67). If validated, this detection will have profound impacts on the current paradigm of structure formation within [Formula: see text]CDM cosmology. We present an attempt to detect the spectral signature reported by the EDGES collaboration with the Long Wavelength Array station located on the Sevilleta National Wildlife Refuge in New Mexico, USA (LWA-SV). LWA-SV differs from other instruments in that it is a 256 element antenna array and offers beamforming capabilisties that should help with calibration and detection. We report first limits from LWA-SV and look toward future plans to improve these limits.
Generalized Points-to Graphs
Authors: Gharat Pritam M. , Khedker Uday P. , Mycroft Alan 
Published: May 2020

Computing precise (fully flow- and context-sensitive) and exhaustive (as against demand-driven) points-to information is known to be expensive. Top-down approaches require repeated analysis of a procedure for separate contexts. Bottom-up approaches need to model unknown pointees accessed indirectly through pointers that may be defined in the callers and hence do not scale while preserving precision. Therefore, most approaches to precise points-to analysis begin with a scalable but imprecise method and then seek to increase its precision. We take the opposite approach in that we begin with a precise method and increase its scalability. In a nutshell, we create naive but possibly non-scalable procedure summaries and then use novel optimizations to compact them while retaining their soundness and precision.

For this purpose, we propose a novel abstraction called the
generalized points-to graph
(GPG), which views points-to relations as memory updates and generalizes them using the counts of indirection levels leaving the unknown pointees implicit. This allows us to construct GPGs as compact representations of bottom-up procedure summaries in terms of memory updates and control flow between them. Their compactness is ensured by strength reduction (which reduces the indirection levels), control flow minimization (which removes control flow edges while preserving soundness and precision), and call inlining (which enhances the opportunities of these optimizations).

The effectiveness of GPGs lies in the fact that they discard as much control flow as possible without losing precision. This is the reason GPGs are very small even for main procedures that contain the effect of the entire program. This allows our implementation to scale to 158 kLoC for C programs.
At a more general level, GPGs provide a convenient abstraction to represent and transform memory in the presence of pointers. Future investigations can try to combine it with other abstractions for static analyses that can benefit from points-to information.
A Cell-Based MAPK Reporter Assay Reveals Synergistic MAPK Pathway Activity Suppression by MAPK Inhibitor Combination in BRAF-Driven Pediatric Low-Grade Glioma Cells
Authors: Usta Diren , Sigaud Romain , Buhl Juliane L. , Selt Florian , Marquardt Viktoria , Pauck David , Jansen Jennifer , Pusch Stefan , Ecker Jonas , Hielscher Thomas , Vollmer Johanna , Sommerkamp Alexander C. , Rubner Tobias , Hargrave Darren , van Tilburg Cornelis M. , Pfister Stefan M. , Jones David T.W. , Remke Marc , Brummer Tilman , Witt Olaf , Milde Till 
Published: May 2020

Abstract
Pilocytic astrocytomas as well as other pediatric low-grade gliomas (pLGG) exhibit genetic events leading to aberrant activation of the MAPK pathway. The most common alterations are KIAA1549:BRAF fusions and BRAFV600E and NF1 mutations. Novel drugs targeting the MAPK pathway (MAPKi) are prime candidates for the treatment of these single-pathway diseases. We aimed to develop an assay suitable for preclinical testing of MAPKi in pLGGs with the goal to identify novel MAPK pathway–suppressing synergistic drug combinations. A reporter plasmid (pDIPZ) with a MAPK-responsive ELK-1–binding element driving the expression of destabilized firefly luciferase was generated and packaged using a lentiviral vector system. Pediatric glioma cell lines with a BRAF fusion (DKFZ-BT66) and a BRAFV600E mutation (BT-40) background, respectively, were stably transfected. Modulation of the MAPK pathway activity by MAPKi was measured using the luciferase reporter and validated by detection of phosphorylated protein levels. A screening of a MAPKi library was performed, and synergy of selected combinations was calculated. Screening of a MAPKi library revealed MEK inhibitors as the class inhibiting the pathway with the lowest IC50s, followed by ERK and next-generation RAF inhibitors. Combination treatments with different MAPKi classes showed synergistic effects in BRAF fusion as well as BRAFV600E mutation backgrounds. Here, we report a novel reporter assay for medium- to high-throughput preclinical drug testing in pLGG cell lines. The assay confirmed MEK, ERK, and next-generation RAF inhibitors as potential treatment approaches for KIAA1549:BRAF and BRAFV600E-mutated pLGGs. In addition, the assay revealed that combination treatments synergistically suppressed MAPK pathway activity.
Nearchus, Guides, and Place Names on Alexander’s Expedition
Authors: James Dylan 
Published: May 2020

Abstract
The use of ὀνοµαζόµενα at Arr. Ind. 27.1 continues to puzzle scholars. This article uses the textual debate as a jumping-off point to explore Nearchus’ presentation of naval guides and their role on Alexander’s expedition, something which previous interpretations of the passage have not adequately considered. Through examination of all Nearchan fragments, I argue that providing local place names was a key aspect of a guide’s role and significant for navigation. It is also suggested that the use of this verb may additionally refer to the Macedonians’ practice of giving places new names or altering indigenous names; in this section, comparative material from New World conquest is brought to bear on the ancient evidence. In light of this analysis, I conclude that the manuscript reading of ὀνοµαζόµενα should be retained.
The use of stimulants in depression: Results from a self-controlled register study
Authors: Rohde Christopher , Brink Philip , Østergaard Søren D , Nielsen Jimmi 
Published: May 2020

Objective: To investigate the effectiveness of stimulants in patients with depression, by using naturalistic outcome measures, such as psychiatric admissions, psychiatric bed-days and incidents of intentional self-harm or suicide attempts. Methods: Via linkage of the Danish nationwide health registers, we identified all patients with a diagnosis of depression initiating stimulants, including methylphenidate, modafinil, amphetamine, dexamphetamine or lisdexamphetamine, from 1995 to 2012. We used a mirror-image model to test whether redemption of a stimulant prescription was associated with a reduction in psychiatric admissions, inpatient days and incidents of intentional self-harm or suicide attempts. Specifically, the number of these outcomes in the 2 years leading up to redemption of a stimulant prescription was compared to the two subsequent years. Similar outcomes were used in a reverse mirror-image model to investigate the effect of stimulant termination. Results: A total of 3354, 935 and 105 patients diagnosed with depression redeemed prescriptions for methylphenidate, modafinil or amphetamine/dexamphetamine/lisdexamphetamine, respectively. Initiation of methylphenidate was not associated with a significant change in psychiatric admissions (mean: −0.02 admissions, p = 0.11) or inpatient days (mean: 0.13 days, p = 0.74). Similar findings were made for modafinil and the amphetamines. In addition, no clinically relevant change in psychiatric admissions or inpatient days was found after termination of a stimulant. After initiation of methylphenidate, the incidents of self-harm or suicide attempts were reduced by 54%, from 68 to 31 events ( p = 0.004). No significant change in incidents of self-harm or suicide attempts were found for modafinil or the amphetamines. Conclusion: This nationwide study, using naturalistic outcomes, does not support the use of stimulants in patients with depression. However, the use of methylphenidate was associated with a 54% reduction in incidents of self-harm or suicide attempts, indicating that methylphenidate may potentially be useful in patients with depression with suicidal- or self-harming behaviour. However, further studies are needed, before any firm conclusions can be made.
Effect of boiler oversizing on efficiency: a dynamic simulation study
Authors: Bennett George , Elwell Cliff 
Published: May 2020

Gas boilers dominate domestic heating in the UK, and significant efficiency improvements have been associated with condensing boilers. However, the potential remains for further efficiency improvement by refining the control, system specification and installation in real dwellings. Dynamic building simulation modelling, including detailed heating system componentry, enables a deeper analysis of boiler underperformance. This paper explores the link between the space heat oversizing of boilers and on/off cycling using dynamic simulation, and their subsequent effect on boiler efficiency and internal temperatures. At plant size ratio (PSR) 8.5 daily cycles numbered over 50, similar to median levels seen in real homes. Simulations show that typical oversizing (PSR >3) significantly increases cycling behaviour and brings an efficiency penalty of 6–9%. There is a clear link between raising PSR, increased cycling and an associated decreased efficiency; however, in the UK, boilers are regularly oversized with respect to space heating, especially combination boilers to cover peak hot water demand. Current legislation and labelling (ErP and SAP) overlook PSR as a determinant of system efficiency, failing to incentivise appropriate sizing. Reducing boiler oversizing through addressing installation practices and certification has the potential to significantly improve efficiency at low cost, decreasing associated carbon emissions. Practical application: This research provides the basis for a practical and cost effective means of assessing the potential for underperformance of boiler heating systems at the point of installation or refurbishment. By assessing the oversizing of the boiler with respect to space heating, unnecessary cycling and the associated efficiency penalty can be avoided. Plant size ratio, as an indicator of cycling potential, can be implemented in energy performance certificates (EPCs), through the standard assessment procedure (SAP), using existing data. The potential for real carbon savings in the existing boiler stock is considerable, and the findings have wider implications for next generation heating systems.
Cerebellar syndrome after occipital nerve block: A case report
Authors: Pincherle Alessandro , Bolyn Serge 
Published: May 2020

Background Occipital nerve blocks are commonly used in the treatment of different types of refractory headaches. The procedure is considered safe, and serious complications have rarely been described. Case presentation We report a serious complication of occipital nerve blockade secondary to the penetration of local anesthetic and non-steroidal anti-inflammatory drugs into the posterior fossa in a patient affected by type I Arnold Chiari malformation. Conclusions This case reminds that a proper injection technique is mandatory to avoid potentially severe complications when performing occipital nerve blocks.
Store-and-forward teledermatology impact on diagnosis, treatment and dermatology referrals: Comparison between practice settings
Authors: Pasadyn Selena R , McAfee John L , Vij Alok , Warren Christine B 
Published: May 2020

Introduction Store-and-forward (SAF) teledermatology involves non-dermatologists sending clinical images to dermatologists. This improves patient care while reducing unwarranted face-to-face (FTF) specialist office visits. Comparisons between dermatologist diagnostic concordance with referring provider, treatment change recommendations, and FTF referrals have yet to be compared by type of provider and practice setting. Methods This retrospective chart review examined SAF teledermatology eConsults from four practice settings: Doctor of Medicine (MD)/Doctor of Osteopathic Medicine (DO) office visits, MD/DO walk-in clinics, nurse practitioner (NP)/physician assistant (PA) office visits and NP/PA walk-in clinics. The most recent 100 MD/DO office- and 100 NP/PA walk-in-referred patient charts were reviewed. There were only 71 NP/PA office and 47 MD/DO walk-in eConsults to review. Results Teledermatologists agreed with referring provider diagnoses 50% of the time for MD/DO office visits, 29.8% for MD/DO walk-in clinics, 33.8% for NP/PA office visits and 34% for NP/PA walk-in clinics. Diagnostic concordance was significantly higher for eConsults from MD/DO office visits than MD/DO walk-in clinics ( p = 0.021), NP/PA office visits ( p = 0.035) or NP/PA walk-in clinics ( p = 0.022). There were significantly more treatment changes recommended after walk-in eConsults than office visits (67 versus 44%, p < 0.0001). FTF visits were recommended more after office visits than walk-in clinics (46 versus 27%, p = 0.001). Overall, 21% (68/318) of patients ultimately attended FTF appointments. Discussion SAF teledermatology improves diagnosis, reducing barriers to specialty care. Overall, potential FTF visit reduction was 79%. Expanding eConsult programmes, particularly in walk-in settings, and for use by NP/PAs or early career internists, may render dermatological care more expeditiously and avoid unnecessary FTF visits.
Constraints on speech rate: A heritage-language perspective
Authors: Nagy Naomi , Brook Marisa 
Published: May 2020

Research questions: Polinsky argues that speech rate in heritage languages is highly correlated with proficiency level. In sociolinguistics studies, speech rate in monolingual speakers is found to be conditioned by social factors. What occurs when both proficiency and social factors vary? Is speech rate a valid measure of proficiency? Methodology: We use two automated methods of measuring articulation rate (syllables per second), cross-referenced to improve accuracy: an orthographic vowel count and an acoustic measure of amplitude changes from syllable nucleus to periphery. Data and analysis: Across 51 speakers, each recorded in an hour-long conversation in Heritage Italian, Russian, Ukrainian, or Homeland Italian, we calculate speech rate in more than 10,000 clauses. Findings: Linear regression analyses reveal that articulation rate correlates with generation (since immigration) and age, but, surprisingly, not with ethnic orientation, sex or language. Age and generation are partly collinear in our sample, and models with generation fit better than those with age. We also find that articulation rate does not predict performance on sociolinguistic variables (voice onset time for stops, subject pronoun presence) in heritage varieties. Originality: This study compares two ways of calculating articulation rate automatically, examining whether speech rate is a viable stand-in for proficiency when social factors and proficiency vary independently. We resolve several obstacles to using articulation rate as a stand-in for more labor-intensive proficiency measures in spontaneous speech data. Implications: These findings suggest that speech rate is a valid proxy for heritage language proficiency. The factor with the strongest effect is generation since immigration (indicating the dominant language in the speaker’s childhood community). The effects of the social factors are complex but must be considered in order to interpret the proficiency measure accurately.
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Authors: Pravednikova Anna E. , Shevchenko Sergey Y. , Kerchev Victor V. , Skhirtladze Manana R. , Larina Svetlana N. , Kachaev Zaur M. , Egorov Alexander D. , Shidlovskii Yulii V. 
Published: May 2020

AbstractThe hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is evidence that dysfunction of brown adipose tissue (BAT) may be a risk factor for obesity and type 2 diabetes (T2D). A significant number of studies in the field focus on the UCP family. TheUcpgenes code for electron transport carriers. UCP1 (thermogenin) is the most abundant protein of the UCP superfamily and is expressed in BAT, contributing to its capability of generating heat. Single nucleotide polymorphisms (SNPs) ofUcp1–Ucp3were recently associated with risk of cardiometabolic diseases. This review covers the mainUcpSNPs A–3826G, A–1766G, A–112C, Met229Leu, Ala64Thr (Ucp1), Ala55Val, G–866A (Ucp2), and C–55 T (Ucp3), which may be associated with the development of obesity, disturbance in lipid metabolism, T2D, and cardiovascular diseases.
Understanding the role of total knee arthroplasty for primary treatment of tibial plateau fracture: a systematic review of the literature
Authors: Wong Murray T. , Bourget-Murray Jonathan , Johnston Kelly , Desy Nicholas M. 
Published: May 2020

AbstractBackgroundSurgical fixation of tibial plateau fracture in elderly patients with open reduction and internal fixation (ORIF) provides inferior outcomes compared with younger patients. Primary total knee arthroplasty (TKA) may be of benefit in elderly patients with a combination of osteoporotic bone and metaphyseal comminution. However, there continues to be conflicting evidence on the use of TKA for primary treatment of tibial plateau fracture. This systematic review was performed to quantify the outcomes and perioperative complication rates of TKA for primary treatment of tibial plateau fracture.Materials and methodsA comprehensive search of MEDLINE, Embase, and PubMed databases from inception through March 2018 was performed in accordance with PRISMA guidelines. Two reviewers independently screened papers for inclusion and identified studies featuring perioperative complications and outcomes of primary TKA for tibial plateau fracture. Weighted means and standard deviations are presented for each outcome.ResultsSeven articles (105 patients) were eligible for inclusion. All-cause mortality was 4.75 ± 4.85%. The total complication rate was 15.2 ± 17.3%. Regarding outcomes, Knee Society scores were most commonly reported. The average Knee Society Knee Score was 85.6 ± 5.5, while the average Knee Society Function Score was 64.6 ± 13.7. Average range of motion at final follow-up was 107.5 ± 10.0°.ConclusionsPrimary TKA for select tibial plateau fractures has acceptable clinical outcomes but does not appear to be superior to ORIF. It may be appropriate to treat certain geriatric patients with TKA to allow for early mobilization and reduce the need for reoperation. Other factors may need to be considered in deciding the optimal treatment.Level of evidenceLevel III.