bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in adolescent drinking across 39 high-income countries: exploring the timing and magnitude of decline
Authors: Vashishtha Rakhi , Pennay Amy , Dietze Paul , Marzan Melvin Barrientos , Room Robin , Livingston Michael 
Published: September 2020

Abstract

Background
Evidence suggests adolescent alcohol consumption has declined since the turn of the millennium in almost all high-income countries. However, differences in the timing and magnitude of the decline have not been explored across countries.

Methods
We examined trends in adolescent past month or monthly alcohol consumption prevalence from cross-national or national survey reports for 39 countries and four US territories. For each country, we calculated the magnitude of the decline in youth drinking as the relative change in prevalence from the peak year to the most recent year available. Heat maps were utilized to present the timing and magnitudes of these declines.

Results
The timing and extent of youth drinking declines have varied markedly across countries. The decline began in the USA before 1999, followed by Northern European countries in the early 2000s; Western Europe and Australasia in the mid-2000s. The steepest declines were found for Northern Europe and the UK, and the shallowest declines were observed in Eastern and Southern European countries.

Conclusions
Previous analyses of the decline in adolescent drinking have emphasized the wide reach of the changes and their near-coincidence in time. Our analysis points to the other side of the picture that there were limits to the wide reach, and that there was considerable variation in timing. These findings suggest that as well as broader explanations that stretch across countries, efforts to explain recent trends in adolescent drinking should also consider factors specific to countries and regions.
Loose Coordination or Ideological Contestation? Transnational Party Activities of German Political Parties on the EU Military Operation EUNAVFOR Med
Authors: Groen Afke 
Published: September 2020

AbstractThis article examines cross-national coordination on foreign and security policy among political parties of the same family. Drawing on resource dependence theory, it presents a case study of German political parties and their transnational activities on the controversial EU military operation to combat human trafficking in the Mediterranean Sea, EU Naval Force Mediterranean. The article finds evidence for transnational information exchange and coordination among the opposition parties, radical left and the greens, but less so among the government party, social democrats. The degree of transnational party activities can be understood by not only the extent to which parties share a common view in the first place but also the different resource needs of the government and opposition parties.
Adult Children’s Daily Experiences With Parental Advice: The Importance of Life Problems and Relationship Quality
Authors: Wang Haowei , Kim Kyungmin , Burr Jeffrey A , Birditt Kira S , Fingerman Karen L 
Published: September 2020

Abstract

Objectives
Parents often provide advice to their adult children during their everyday interactions. This study investigated young adult children’s daily experiences with parental advice in U.S. families. Specifically, the study examined how receiving advice and evaluations of parental advice were associated with children’s life problems, parent–child relationship quality, and daily mood.

Methods
Young adult children (aged 18–30 years; participant N = 152) reported whether they received any advice and perceived any unwanted advice from each parent (parent N = 235) for 7 days using a daily diary design (participant-day N = 948). Adult children also reported their positive and negative mood on each interview day.

Results
Results from multilevel models revealed that adult children who reported a more positive relationship with their parents were more likely to receive advice from the parent, whereas adult children who had a more strained relationship with their parents were more likely to perceive advice from the parent as unwanted. Receiving advice from the mother was associated with increased positive mood, whereas unwanted advice from any parent was associated with increased negative mood. Furthermore, the link between unwanted advice and negative mood varied by children’s life problems and parent–child relationship quality.

Discussion
Indeed, parental advice is not “the more the better,” especially when the advice is unsolicited. This study highlights the importance of perceptions of family support for emerging adults’ well-being.
Benchmarking wave equation solvers using interface conditions: the case of porous media
Authors: Peng Haorui , Sripanich Yanadet , Vasconcelos Ivan , Trampert Jeannot 
Published: September 2020

SUMMARYThe correct implementation of the continuity conditions between different media is fundamental for the accuracy of any wave equation solver used in applications from seismic exploration to global seismology. Ideally, we would like to benchmark a code against an analytical Green’s function. The latter, however, is rarely available for more complex media. Here, we provide a general framework through which wave equation solvers can be benchmarked by comparing plane wave simulations to transmission/reflection (R/T) coefficients from plane-wave analysis with exact boundary conditions (BCs). We show that this works well for a large range of incidence angles, but requires a lot of computational resources to simulate the plane waves. We further show that the accuracy of a numerical Green’s function resulting from a point-source spherical-wave simulation can also be used for benchmarking. The data processing in that case is more involved than for the plane wave simulations and appears to be sufficiently accurate only below critical angles. Our approach applies to any wave equation solver, but we chose the poroelastic wave equation for illustration, mainly due to the difficulty of benchmarking poroelastic solvers, but also due to the growing interest in imaging in poroelastic media. Although we only use 2-D examples, our exact R/T approach can be extended to 3-D and various cases with different interface configurations in arbitrarily complex media, incorporating, for example, anisotropy, viscoelasticity, double porosities, partial saturation, two-phase fluids, the Biot/squirt flow and so on.
The moderate size 2019 September Mw 5.8 Silivri earthquake unveils the complexity of the Main Marmara Fault shear zone
Authors: Karabulut Hayrullah , Güvercin Sezim Ezgi , Eskiköy Figen , Konca Ali Özgun , Ergintav Semih 
Published: September 2020

SUMMARYThe unbroken section of the North Anatolian Fault beneath the Sea of Marmara is a major source of seismic hazard for the city of İstanbul. The northern and currently the most active branch, the Main Marmara Fault (MMF), is segmented within a shear zone and exhibits both partially creeping and locked behaviour along its 150 km length. In 2019 September, a seismic activity initiated near MMF, off-coast the town of Silivri, generating 14 earthquakes ≥ Mw 3.5 in a week. The Mw 5.8 Silivri earthquake, is the largest in the Marmara Sea since the 1963 Mw 6.3 Çınarcık earthquake. Our analyses reveal that the activity started in a narrow zone (∼100 m) and spread to ∼7 km following an Mw 4.7 foreshock within ∼2 d. The distribution of relocated aftershocks and the focal mechanisms computed from regional waveforms reveal that the Mw 5.8 earthquake did not occur on the MMF, but it ruptured ∼60° north-dipping oblique strike-slip fault with significant thrust component located on the north of the MMF. Finite-fault slip model of the main shock shows 8 km long rupture with directivity toward east, where the ruptured fault merges to the MMF. The narrow depth range of the slip distribution (10–13 km) and the aftershock zone imply that the causative fault is below the deep sedimentary cover of the Marmara Basin. The distribution of aftershocks of the Mw 5.8 event is consistent with Coulomb stress increase. The stress changes along MMF include zones of both stress decrease due to clamping and right-lateral slip, and stress increase due to loading.
Identifying dimensions of empowerment in patients with inflammatory bowel disease: a qualitative study
Authors: Zare Fatemeh , Ghafari Mohtasham , Ramezankhani Ali , Kamran Bagheri Lankarani , Kavoosi Amir 
Published: September 2020

Abstract
The role of patients’ empowerment in enhancing the quality of life of chronic patients is undeniable and its importance in health policy making and health care is increasing day by day. However, no guidelines have been defined to empower people with inflammatory bowel disease (IBD). The purpose of this study was to identify the dimensions of IBD patients’ empowerment. Semi-structured interviews were conducted with 26 participants who were purposefully selected from 2 IBD clinics in Tehran and Shiraz cities to gain diversity in the clinical and demographic characteristics. The data were analyzed based on the Granheim and Landman’s content analysis method. According to the result of this study, the empowerment of IBD patients is composed of five dimensions including self-care, psychological coping with disease, social interaction skills, disease-specific health literacy and self-evaluation. The participants’ most emphasis was on self-care and psychological coping dimensions. These findings can be used as a basis for educational interventions toward IBD patients’ empowerment. More researches are needed to explore factors affecting the empowerment processes of IBD patients.
Epidemiology and Clinical Outcomes of Patients With Inflammatory Bowel Disease Presenting With Acute Coronary Syndrome
Authors: Pemmasani Gayatri , Elgendy Islam , Mamas Mamas A , Leighton Jonathan A , Aronow Wilbert S , Tremaine William J 
Published: September 2020

Abstract

Background
Inflammatory bowel disease (IBD) is associated with an increased acute coronary syndrome (ACS) risk. Data are limited regarding the epidemiology and outcomes of ACS in patients with IBD.

Methods
A retrospective cohort analysis of patients with IBD admitted for ACS in the U.S. Healthcare Cost and Utilization Project National Inpatient Sample for 2005 to 2015 was conducted. We analyzed trends in IBD-ACS admissions and mortality, differences in risk profiles, management strategies, and in-hospital mortality between IBD-ACS and non-IBD ACS and between ulcerative colitis (UC) and Crohn disease (CD).

Results
We studied 6,872,415 non-IBD ACS and 24,220 IBD-ACS hospitalizations (53% with CD). During the study period, the number of hospitalizations for IBD-ACS increased, particularly those related to CD. Compared with non-IBD ACS, patients with IBD-ACS had a lower prevalence of cardiovascular risk factors and similar rates of coronary angiography and revascularization. The in-hospital mortality rate was lower with IBD-ACS (3.9%) compared with non-IBD ACS (5.3%; odds ratio, 0.81; 95% confidence interval, 0.69-0.96; P = 0.011) and was stable between 2005 and 2015. Risk factors, ACS management strategies, and mortality were similar between CD and UC. Coagulopathy, weight loss, and gastrointestinal bleeding were more frequent in IBD-ACS and were strong independent predictors of mortality.

Conclusions
Hospitalizations for ACS in patients with IBD increased in recent years but death rates were stable. The ACS-related risk profiles and mortality were modestly favorable with IBD-ACS than with non-IBD ACS and were similar between CD and UC. Complications more frequently associated with IBD were strongly associated with mortality. These findings indicate that aggressive management of IBD and ACS comorbidities is required to improve outcomes.
Adipokine Resistin Levels at Time of Pediatric Crohn Disease Diagnosis Predict Escalation to Biologic Therapy
Authors: Kurowski Jacob A , Achkar Jean-Paul , Gupta Rishi , Barbur Iulia , Bonfield Tracey L , Worley Sarah , Remer Erick M , Fiocchi Claudio , Viswanath Satish E , Kay Marsha H 
Published: September 2020

Abstract

Background
Hypertrophy of visceral adipose tissue (VAT) is a hallmark of Crohn disease (CD). The VAT produces a wide range of adipokines, biologically active factors that contribute to metabolic disorders in addition to CD pathogenesis. The study aim was to concomitantly evaluate serum adipokine profiles and VAT volumes as predictors of disease outcomes and treatment course in newly diagnosed pediatric patients with CD.

Methods
Pediatric patients ages 6 to 20 years were enrolled, and their clinical data and anthropometric measurements were obtained. Adipokine levels were measured at 0, 6, and 12 months after CD diagnosis and baseline in control patients (CP). The VAT volumes were measured by magnetic resonance imaging or computed tomography imaging within 3 months of diagnosis.

Results
One hundred four patients undergoing colonoscopy were prospectively enrolled: 36 diagnosed with CD and 68 CP. The serum adipokine resistin and plasminogen activator inhibitor (PAI)-1 levels were significantly higher in patients with CD at diagnosis than in CP. The VAT volume was similar between CD and CP. Baseline resistin levels at the time of diagnosis in patients with CD who were escalated to biologics was significantly higher than in those not treated using biologic therapy by 12 months (29.8 ng/mL vs 13.8 ng/mL; P = 0.004). A resistin level of ≥29.8 ng/mL at the time of diagnosis predicted escalation to biologic therapy in the first year after diagnosis with a specificity of 95% (sensitivity = 53%; area under the curve = 0.82; P = 0.015 for model with log-scale). There was a significantly greater reduction in resistin (P = 0.002) and PAI-1 (P = 0.010) at the 12-month follow-up in patients on biologics compared with patients who were not treated using biologics.

Conclusions
Serum resistin levels at diagnosis of pediatric CD predict the escalation to biologic therapy at 12 months, independent of VAT volumes. Resistin and PAI-1 levels significantly improved in patients with CD after treatment using biologics compared with those not on biologics. These results suggest the utility of resistin as a predictive biomarker in pediatric CD.
Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury
Authors: Liu Pei , Chen Jianjun , Ma Shuai , Zhang Jianjun , Zhou Jianyu 
Published: September 2020

AbstractBackgroundNeuropathic pain is a multifaceted and ubiquitous disease across the globe. Mood disorders, such as anxiety and depression, are frequently observed in patients suffering from neuropathic pain. Both neuropathic pain and comorbid mood disorders seriously impact quality of life. Accumulated evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the neuroinflammatory pathogenesis of neuropathic pain, anxiety, and depression. However, the role of the NLRP3 inflammasome in the pathological process of anxiety and depression under the neuropathic pain state has not been fully described. Albiflorin, a monoterpene glycoside, may be a potential regulator of the NLRP3 inflammasome, but it is not clear whether albiflorin relates to NLRP3 inflammasome activation.MethodsWe used a systematic pharmacological method to confirm whether the activation of the NLRP3 inflammasome in the hippocampus was involved in the development of neuropathic pain associated with mood disorders and whether albiflorin could be an effective treatment for these symptoms.ResultsThe NLRP3 inflammasome contributed to the neuropathic pain and comorbid anxiety and depression-like behaviors induced by chronic constriction injury of the sciatic nerve, and albiflorin may relieve these symptoms via inhibition of the NLRP3 inflammasome activity. Moreover, albiflorin enhanced the translocation of the nuclear factor erythroid 2-related factor 2 into the nucleus and suppressed nuclear factor-kappa B activity in the hippocampus.ConclusionsAlbiflorin, as a potential therapeutic agent, might greatly improve the overall symptoms of neuropathic pain.
The SciPop Scale for Measuring Science-Related Populist Attitudes in Surveys: Development, Test, and Validation
Authors: Mede Niels G. , Schäfer Mike S. , Füchslin Tobias 
Published: September 2020

Abstract
Populism typically pits political elites against “the virtuous people.” A distinct variant of populism (“science-related populism”) extends beyond politics, targeting academic elites and suggesting they ignore people’s common sense and will. Individual endorsement of such a worldview (“science-related populist attitudes”) has been conceptualized but not yet measured. Hence, we developed the SciPop Scale, a survey instrument to measure science-related populist attitudes. We tested 17 survey items in a first representative survey and developed an 8-item scale. We then tested German, French, and Italian versions of this scale in a second representative survey, employing confirmatory factor analysis, Item Response Theory, and external validity tests. Findings show that the SciPop Scale is a robust and reliable measure of populist demands toward science.
Identification of Biomarkers for Diagnosis and Prognosis of Congenital and Acute Toxoplasmosis
Authors: Storchilo Heloisa Ribeiro , Teixeira Giulianne Monteiro , Moreira André Luís Elias , Gomes Taynara Cristina , Borges Clayton Luiz , de Castro Ana Maria 
Published: September 2020

Abstract

Background
The diagnosis of congenital toxoplasmosis can be inconclusive in many cases. Despite the several serological tests developed, the literature on biomarkers that can assist in the diagnosis of congenital an acute toxoplasmosis is limited. The objective of this study was to analyze the immunoreactive profile of Toxoplasma gondii protein bands with the potential to be biomarkers for diagnosis and prognosis of congenital and acute toxoplasmosis.

Methods
Peripheral blood samples from women of childbearing age and/or pregnant women diagnosed with acquired toxoplasmosis as well as from congenitally infected children were selected and submitted to immunoblotting for analysis of the immunoreactive bands profile by immunoglobulin G (IgG) antibodies.

Results
When comparing the immunoreactive bands profile for antibodies present in samples from different groups and subgroups, the 150, 18.5, and 16.96-kDa bands were more immunoreactive with the antibodies present in serum samples from the acquired infection group. The 343, 189, 150, 75, and 42-kDa bands showed more chance to be detected by the symptomatic congenital infection subgroup samples, while the 61, 50, and 16.96-kDa bands were significantly immunoreactive with the acute infection subgroup samples.

Conclusions
The identification of these potential biomarkers can assist in early diagnosis and treatment of congenital toxoplasmosis.
Feasibility of a community pharmacy antimicrobial stewardship intervention (PAMSI): an innovative approach to improve patients’ understanding of their antibiotics
Authors: Allison Rosalie , Chapman Sarah , Howard Philip , Thornley Tracey , Ashiru-Oredope Diane , Walker Sue , Jones Leah F , McNulty Cliodna A M 
Published: September 2020

Abstract

Background
Community pharmacy staff have an opportunity to play a pivotal role in antimicrobial stewardship (AMS) due to their expertise in medicines and accessibility to patients.

Objectives
To develop and test the feasibility of a pharmacy AMS intervention (PAMSI) to increase community pharmacy staff’s capability, opportunity and motivation to check antibiotic appropriateness and provide self-care and adherence advice when dispensing antibiotics.

Methods
The PAMSI was centred around an Antibiotic Checklist, completed by patients and pharmacy staff, to facilitate personalized advice to the patient, based on their reported knowledge. An educational webinar for staff and patient-facing materials were also developed. Staff and patients completing Antibiotic Checklists were invited to provide feedback via questionnaires.

Results
In February 2019, 12 community pharmacies in England trialled the intervention. Forty-three pharmacy staff evaluated the educational webinar and reported increases in their understanding, confidence, commitment and intention to use the tools provided to give adherence and self-care advice. Over 4 weeks, 931 Antibiotic Checklists were completed. Staff reported being more focused on giving advice and able to address patients’ knowledge gaps (mainly: likely symptom duration; alcohol and food consumption advice; possible side effects from antibiotics; returning unused antibiotics to the pharmacy), resulting in increased self-reported effective and meaningful conversations.

Conclusions
Implementation of a PAMSI is feasible and effectively promotes AMS. Pharmacy staff and commissioners should consider this within their AMS plans. An optional digital format of the Antibiotic Checklist should be explored, for patients who are not collecting their antibiotic prescriptions themselves, and to save printing costs.
Health Disparities among Australia’s Remote-Dwelling Aboriginal People: A Report from 2020
Authors: Davey Richard X 
Published: September 2020

Abstract

Background
Australia has 2 distinct indigenous groups, Torres Strait Islanders and Aborigines. The Aborigines, described in this report, first colonized the continent 65 millennia ago. Those still living in the Northern Territory (NT) retain much ancestrally derived genetic complement but also are the most health-challenged by environment and lifestyle in 21st century. Reports providing overviews of these disparities are, as yet, rare.

Content
This review defines the studied population and then describes and attempts to explain contemporary clinical findings among Australia’s remote-dwelling Aborigines, principally in the NT. The report is structured by life stage and then by organ system. Finally, a brief synthesis is advanced concerning the disparities that Australia’s Aboriginals face.

Summary
In 2015–2017, NT aboriginal life expectancy for people then born was 66.6 years for men and 69.9 years for women compared with 78.1 and 82.7 years, respectively, among nonindigenous Territorians. Principal causes of the reduced longevity, with nonindigenous comparisons, include adolescent pregnancy, with maternal use of alcohol and tobacco (each 7-fold greater); fetal alcohol spectrum disorder and attention deficit hyperactivity disorder; skin infections, both scabies and impetigo (50-fold greater); rheumatic heart disease (260-fold greater); premature acute myocardial infarction (9-fold greater); bronchiectasis (40-fold greater); lung cancer (2-fold greater); diabetes mellitus (10-fold greater); renal failure (30-fold greater); and suicide (2-fold greater). Some disease has genetic roots, secondary to prolonged genetic drift. Much arises from avoidable stressors and from contemporary environmental disparities in housing. The Europid diet is also not helpful.