bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTS OF INTRAVENOUS ABT‐870 (IRON (III)‐HYDROXIDE OLIGOSACCHARIDE) ON MEAN ARTERIAL PRESSURE AND HEART RATE IN THE ANAESTHETIZED BEAGLE: COMPARISON WITH OTHER IRON‐CONTAINING HAEMATINIC AGENTS
Authors: Preusser Lee C , Fryer Ryan M , Gerhardt Armin , Hu Yanhui , Delgado‐Herrera Leticia , Melnick Joel Z , Williams Laura A , Cox Bryan F , Reinhart Glenn A 
Published: November 2019

SUMMARY

Iron‐deficiency anaemia, a complication of end‐stage renal disease (ESRD), is often treated with parenteral iron therapies that have been shown to produce dose‐limiting hypotension in patients. ABT‐870 (iron‐(III)hydroxide‐oligosaccharide) is comprised of elemental iron complexed with oligosaccharide, a composition that we hypothesised would allow the hypotensive effects of parenteral iron therapy to be overcome, thus allowing a rapid rate of infusion to be well tolerated.
Mean arterial pressure (MAP) and heart rate (HR) were monitored in anaesthetized dogs following the infusion of ABT‐870 and iron sucrose administered at doses of 7.1 and 21.3 mg/kg using a rapid 30 s infusion. ABT‐870 and iron sucrose were also monitored at doses of 7.1, 21.3 and 50 mg/kg administered over a 10 min period. Sodium ferric gluconate complex (SFGC) was administered in an identical fashion at doses of 12.5 and 31.2 mg/kg.
A 30 s rapid infusion of ABT‐870 at doses of 7.1 and 14.3 mg/kg or a 10 min infusion of ABT‐870 at doses of 7.1 and 21.3 mg/kg produced little effect on MAP and HR. Infusion of the highest dose of ABT‐870 (50 mg/kg) produced no consistent hypotension, but did produce an increase in HR (maximal increase 35 ± 9 b.p.m.), an effect that lasted only 15 min. A 30 s rapid infusion of iron sucrose at 7.1 mg/kg produced modest increases in MAP and HR (5 ± 1 mmHg and 5 ± 2 b.p.m., respectively). However, rapid infusion of iron sucrose at 14.3 mg/kg produced hypotension (to ‐8 ± 1 mmHg below baseline) and exerted variable, biphasic effects on HR ranging from ‐16 to +50 b.p.m. Although 10 min infusion of iron sucrose at 7.1 mg/kg exerted little effect on MAP and HR, at doses of 21.3 and 50 mg/kg iron sucrose elicited a profound dose‐dependent decrease in MAP (‐34 ± 11 and ‐83 ± 5 mmHg, respectively) and a pronounced increase in HR ranging from 32 to 49 b.p.m. above baseline. A 10 min infusion of SFGC at doses of 12.5 and 31.2 mg/kg produced a dose‐dependent decrease in MAP (‐28 ± 18 and ‐67 ± 12 mmHg below baseline) and a marked increase in HR (26 ± 11 and 94 ± 15 b.p.m. above baseline).
In conclusion, unlike iron sucrose and SFGC, high doses of ABT‐870 failed to exert consistent hypotensive effects. These data demonstrate that ABT‐870 may have a substantial therapeutic window and considerable clinical potential for iron‐replacement therapy.
The effects of stricter regulation on the going public decision of small and knowledge‐intensive firms
Authors: Engelen Peter‐Jan , Meoli Michele , Signori Andrea , Vismara Silvio 
Published: November 2019

AbstractThis paper studies the impact of increased securities regulation on the IPOs of small and high‐tech, knowledge‐intensive firms. We take advantage of the adoption of European SOX‐like provisions, staggered at different dates across European countries, to test its influence on the going public decision. Starting from the population of European private firms during 1995–2012, we find that the likelihood of going public has decreased among small and high‐tech, knowledge‐intensive firms. Consistently, we document a 6% and 8.5% decrease in the industry‐adjusted Tobin's Q of small and knowledge‐intensive firms that go public after the regulatory change.
Association between gut microbiota composition and glycoalbumin level during pregnancy in Japanese women: Pilot study from Chiba Study of Mother and Child Health
Authors: Sakurai Kenichi , Kato Tamotsu , Tanabe Hiromi , Taguchi‐Atarashi Naoko , Sato Yumi , Eguchi Akifumi , Watanabe Masahiro , Ohno Hiroshi , Mori Chisato 
Published: November 2019

AbstractAims/IntroductionGut microbiota have various effects on human health. Some previous reports have shown that gut microbiota change during pregnancy and affect metabolism, but others have shown that microbiota do not change. Here, we examined the gut microbiota and glycoalbumin levels of 45 healthy Japanese women during pregnancy.Materials and MethodsWe carried out 16S rRNA gene sequencing analyses of maternal stool samples and compared the gut microbiota composition of samples from women in early and late pregnancy. We also examined the association between gut microbiota and maternal characteristics, including glycoalbumin.ResultsMicrobiota composition in early and late pregnancy did not differ, according to principal coordinate analysis of weighted and unweighted UniFrac distances. Shannon indices were not different between early and late pregnancy. The proportion of one phylum, TM7, significantly decreased in late pregnancy compared with early pregnancy, but the proportions of other major phyla did not change. The Shannon index of late pregnancy was negatively associated with pregestational body mass index and positively correlated with glycoalbumin level, with adjustment of covariates.ConclusionsWe concluded that Japanese women did not show obvious differences in gut microbiota during pregnancy, except for TM7, and that the diversity of gut microbiota might affect maternal metabolism. As this study had limited statistical power, further large‐scale studies are required.
Competition, patent protection, and innovation with heterogeneous firms in an endogenous market structure
Authors: Suzuki Keishun 
Published: November 2019

AbstractThis paper revisits the relationship between competition and innovation by incorporating the heterogeneity of R&D efficiency across firms and an endogenous market structure in a dynamic general equilibrium model. Using an analytically tractable model, we show that competition and innovation can have either an inverted‐U or a negative relationship, as reported by several empirical studies. Furthermore, we show that the effect of strengthening patent protection on innovation depends on the competition level. In particular, we find a complementary relationship between competition policy and the strengthening of patent protection.
Allosteric modulators restore orthosteric agonist binding to mutated CB1 receptors
Authors: Dopart Rachel , Kendall Debra A 
Published: November 2019

Abstract

Objectives
To determine if diminished orthosteric agonist binding due to mutations in extracellular loops 1 or 2 of the cannabinoid receptor 1 (CB1) can be overcome by an allosteric modulator and restore agonist binding.

Methods
Binding assays were performed using a range of concentrations of orthosteric compound, in the presence or absence of a set concentration of the allosteric modulator PSNCBAM-1 to determine the EC50 in its absence or presence.

Key findings
Single mutations in extracellular loop 1 or 2 of CB1 showed weak or no binding of agonist CP55940 to the receptor. Interestingly, upon addition of the allosteric modulator PSNCBAM-1, this binding was restored typically to wild-type CB1 levels. In a few cases, the allosteric modulator ORG27569 was compared with PSNCBAM-1 for CP55940 binding and it also restored binding. Further, wild-type levels of inverse agonist bound the CB1 mutants in the absence of modulator, suggesting the mutants were originally folded like the wild type.

Conclusions
Based on our findings, we provide evidence of a therapeutic application for allosteric modulators in situations where a mutation in the receptor may hinder its function. By utilizing allosteric modulators, restoration of orthosteric binding may be possible.
Phosphorus excretion by mares post‐lactation
Authors: Fowler Ashley L. , Pyles Morgan B. , Hayes Susan H. , Crum Andrea D. , Lawrence Laurie M. 
Published: November 2019

AbstractAcross the equine literature, estimates of true P digestibility range from −23% to 79%. This large range cannot be explained by differences in P intake or phytate‐P intake alone. However, differences in endogenous P secretion into the GI tract may explain the variation. In horses, excess absorbed P is not excreted in the urine but is re‐secreted into the GI tract, increasing faecal P and leading to estimates of low P digestibility. Thus, accurate estimates of P digestibility can only be obtained if absorbed P is retained in the horse. The objective of this study was to examine P digestibility in post‐lactational mares and control mares that were fed similar amounts of P. It was hypothesized that post‐lactational mares would have greater P retention and higher apparent P digestibility than control mares. Prior to the study, four lactating and four non‐lactating mares were fed a diet that provided 100% of the control mares’ P requirement, but only 55% of the lactating mares’ P requirement. During the study, both groups were fed P at the rate recommended for non‐lactating mares. Post‐lactational mares did not retain more P than control mares but tended to excrete more P than control mares (p = .082), presumably due to differences in endogenous P secretion into the GI tract. Metabolic changes occurring during mammary gland involution may have contributed to the increase in P excretion. However, faecal P excretion exceeded P intake in both groups (p = .08) and both groups lost weight during the study. Tissue mobilization during weight loss may have influenced P secretion into the GI tract.
Efficacy and safety of catheter ablation combined with left atrial appendage occlusion for nonvalvular atrial fibrillation: A systematic review and meta‐analysis
Authors: Jiang Ying , Li Fanghui , Li Dongze , Cheng Yisong , Jia Yu , Fu Hua , Pu Xiaobo , Hu Hongde , Jiang Jian , Zeng Rui 
Published: November 2019

AbstractAtrial fibrillation (AF) is currently the most prevalent arrhythmia in clinical practice, with stroke being one of its major complications. Combining catheter ablation and percutaneous left atrial appendage occlusion (LAAO) into a “one‐stop” intervention could reduce stroke incidence in selected high‐risk patients and, at the same time, relieve AF symptoms in a single procedure. This meta‐analysis analyzed the efficacy and safety of catheter ablation combined with LAAO for nonvalvular AF. PubMed, EMBASE, and the Cochrane Library were searched from inception to April 2019 to identify relevant citations. Efficacy indexes were procedural success, AF recurrence, stroke/transient ischemic attacks (TIA), and device‐related thrombus (DRT). Safety indexes were all‐cause death, major hemorrhagic complications, and pericardial effusion/cardiac tamponade. The incidence rate of events (ratio of events to patients) and 95% confidence interval (CI) were calculated as summary results. A forest plot was constructed to present pooled rates. Eighteen studies (two randomized controlled trials and 16 observational studies) were included. The results showed that one‐stop intervention has significant efficacy and safety, with procedural success of .98 (95% CI, .97‐1.00), AF recurrence of .24 (95% CI, .15‐.35), stroke/TIA of .01 (95% CI, .00‐.01), DRT of .00 (95% CI, .00‐.01), all‐cause mortality of .00 (95% CI, .00‐.00), cardiac/neurological mortality of .00 (95% CI, .00‐.00), major hemorrhagic complications of .01 (95% CI, .00‐.02), and pericardial effusion/cardiac tamponade of .01 (95% CI, .00‐.01). A single procedure with catheter ablation and LAAO in AF is a feasible strategy with significant efficacy and safety.
An improved RANSAC algorithm for extracting roof planes from airborne lidar data
Authors: Canaz Sevgen Sibel , Karsli Fevzi 
Published: November 2019

AbstractThe extraction of building roof planes from lidar data has become a popular research topic with random sample consensus (RANSAC) being one of the most commonly adopted algorithms. RANSAC extracts full planes, which is problematic when there are other points outside the plane boundary but within the plane space. This study proposes an improved RANSAC (I‐RANSAC) algorithm by removing points that do not belong to the roof plane. I‐RANSAC selects a random point from the extracted roof plane and then searches for its neighbours within a given threshold to identify and remove outliers. The new algorithm was tested with 14 buildings from two datasets, where quality control measures showed significant improvement over standard RANSAC.
MicroRNA evolution provides new evidence for a close relationship of Diplura to Insecta
Authors: Liu Ai‐Min , Chen Wan‐Jun , Huang Cheng‐Wang , Qian Chang‐Yuan , Liang Yan , Li Sheng , Zhan Shuai , Luan Yun‐Xia 
Published: November 2019

AbstractThe phylogenetic interrelationships among four hexapod lineages (Protura, Collembola, Diplura and Insecta) are pivotal to understanding the origin of insects and the early diversification of Hexapoda, but they have been difficult to clarify based on the available data. In this study, we identified 91 conserved microRNA (miRNA) families from 36 panarthropod taxa, including seven newly sequenced non‐insect hexapods. We found major clade differentiation accompanied by the origin of novel miRNA families, and most miRNA clusters are conserved with a high degree of microsynteny. Importantly, we were able to identify two miRNA families unique to Hexapoda, and four miRNA families and a miRNA cluster that exist exclusively in Diplura and Insecta, suggesting a close relationship between Diplura and Insecta as well as the monophyly of Hexapoda. Combined with a phylogenetic analysis based on the presence/absence matrix of miRNA families, our study demonstrates the effectiveness of miRNA in resolving deep phylogenetic problems.
The MINDBODYSTRONG Intervention for New Nurse Residents: 6‐Month Effects on Mental Health Outcomes, Healthy Lifestyle Behaviors, and Job Satisfaction
Authors: Sampson Marlene , Melnyk Bernadette Mazurek , Hoying Jacqueline 
Published: November 2019

AbstractBackgroundIn 2017, the National Academy of Medicine convened its Action Collaborative for Clinician Well‐being and Resilience in an effort to stem the epidemic levels of burnout, depression, and suicide among healthcare clinicians. Nurses report higher rates of substance abuse, depression, and suicide than the national average. Newly licensed registered nurses (NLRNs) report high levels of burnout and stress. Suboptimal health in nurses is linked to medical errors. Few studies address the mental health and lifestyle behaviors of NLRNs or provide evidence‐based solutions to improve these outcomes.AimsThis study evaluated the 6‐month effects of the MINDBODYSTRONG for Healthcare Professionals program on the mental health, healthy lifestyle behaviors, and job satisfaction of NLRNs participating in a nurse residency program.MethodsA two‐group randomized controlled trial was conducted with 89 NLRNs at a large, Midwestern academic medical center. The intervention group received eight 30– to 35‐min weekly sessions as part of the MINDBODYSTRONG program, a cognitive behavioral skill‐building program incorporating strategies to improve mental and physical health. The control group acted as the attention control group receiving eight weekly 30– to 35‐min debriefing sessions as part of the normal nurse residency program.ResultsData were collected at baseline, immediately postintervention, 3 months postintervention, and 6 months postintervention. The intervention group scored better on mental health outcomes, healthy lifestyle behaviors, and job satisfaction at 6 months postintervention than the control group. Significant improvements were found for depressive symptoms and job satisfaction; there were moderate to large positive effects for the MINDBODYSTRONG program on all variables.Linking Evidence to ActionThe MINDBODYSTRONG program sustained its positive effects across time and has excellent potential as an evidence‐based intervention for improving the mental health, healthy lifestyle behaviors, and job satisfaction in NLRNs.
Toward Understanding Youth Athletes’ Fun Priorities: An Investigation of Sex, Age, and Levels of Play
Authors: Visek Amanda J. , Mannix Heather , Chandran Avinash , Cleary Sean D. , McDonnell Karen A. , DiPietro Loretta 
Published: November 2019

Colloquial conjecture asserts perceptions of difference in what is more or less important to youth athletes based on binary categorization, such as sex (girls vs. boys), age (younger vs. older), and level of competitive play (recreational vs. travel). The fun integration theory’s FUN MAPS, which identify 11 fun-factors comprised of 81 fun-determinants, offers a robust framework from which to test these conceptions related to fun. Therefore, the purposes of this study were to scientifically explore: (a) the extent to which soccer players’ prioritization of the 11 fun-factors and 81 fun-determinants were consistent with the gender differences hypothesis or the gender similarities hypothesis, and (b) how their fun priorities evolved as a function of their age and level of play. Players’ (n = 141) data were selected from the larger database that originally informed the conceptualization of the fun integration theory’s FUN MAPS. Following selection, innovative pattern match displays and go-zone displays were produced to identify discrete points of consensus and discordance between groups. Regardless of sex, age, or level of play, results indicated extraordinarily high consensus among the players’ reported importance of the fun-factors (r = .90–.97) and fun-determinants (r = .92–.93), which were consistently grouped within strata of primary, secondary, and tertiary importance. Overall, results were consistent with the gender similarities hypothesis, thereby providing the first data to dispel common conceptions about what is most fun with respect to sex, in addition to age and level of play, in a sample of youth soccer players.
Inequities in the global representation of sites participating in large, multicentre dialysis trials: a systematic review
Authors: Smyth Brendan , Trongtrakul Konlawij , Haber Anna , Talbot B , Hawley Carmel , Perkovic Vlado , Woodward Mark , Jardine Meg 
Published: November 2019

BackgroundThe number of dialysis recipients is growing worldwide, making it important that the full range of patient populations are represented in randomised trials. As trial recruitment has not previously been examined at a global level, we compared the location of trial sites recruiting to large multicentre randomised controlled trials (RCTs) in dialysis to the global distribution of dialysis recipients.MethodsA systematic review (2007–2016) was conducted to identify RCTs enrolling ≥100 dialysis patients from ≥2 sites. The number and location of sites were extracted from manuscripts and trial registration. The proportion of sites from each International Society of Nephrology global region was divided by the proportion of the global dialysis population in that region to determine a ‘representation index’ (RI), where 1.0 indicated that the number of sites was proportionate to the number of dialysis recipients in that region.ResultsWe identified 180 RCTs, recruiting from 6172 sites in 54 countries. Eastern and Central Europe had the highest RI at 2.45. Other well-represented regions were Western Europe (2.20), North America (2.06), and Russia and newly independent states (1.36). Africa had the lowest RI at 0.05, followed by South Asia (0.08), Latin America (0.15), Middle East (0.27), North-East Asia (0.41), and South-East Asia and Oceania (0.62).ConclusionsRegions of the world with growing numbers of dialysis patients are poorly represented in large, multicentre RCTs. Efforts to boost trial participation in these regions are required to ensure that generalisable and relevant information is available to local healthcare providers.
Epidemiology of venous thromboembolism in people with active tuberculosis: a systematic review and meta-analysis protocol
Authors: Awana Philippe Armel , Danwang Celestin , Tochie Joel Noutakdie , Bigna Jean Joel 
Published: November 2019

IntroductionIn recent years, a hypothesis has been raised that people with tuberculosis are at risk for developing venous thromboembolism (VTE). However, much remains to be understood about the interplay between VTE and tuberculosis. Therefore, through a global systematic review and meta-analysis, the current study aims at investigating the association between exposure to active tuberculosis and risk of VTE, and determining the prevalence and incidence of VTE in people with active tuberculosis.Methods and designWe will include cohort studies, case–control and cross-sectional studies performed among adults (>15 years) with active tuberculosis. EMBASE, Medline, Global Index Medicus and Web of Knowledge will be searched for relevant records published until 31 August 2019, without any language restriction. The review will be reported according to the Meta-analysis Of Observational Studies in Epidemiology guidelines. After screening of titles and abstracts, study selection, data extraction and risk of bias assessment; we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Egger’s test and visual inspection of funnel plots will be used to assess publication bias. Results will be presented by country and region.Ethics and disseminationSince primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data on the epidemiology of VTE in people with tuberculosis. The final report will be published in a peer-reviewed journal.PROSPERO registration numberCRD42019130347.
Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention: a scoping review protocol
Authors: M Selveindran Santhani , Khan Muhammad Mukhtar , Simadibrata Daniel Martin , Hutchinson Peter J A , Brayne Carol , Hill Christine , Kolias Angelos , Joannides Alexis J , Servadei Franco , Rubiano Andres M , Shabani Hamisi K 
Published: November 2019

IntroductionNeurotrauma is an important global health problem. This ‘silent epidemic’ is a major cause of death and disability in adolescents and young adults, with significant societal and economic impacts. Globally, the largest cause of neurotrauma is road traffic collisions (RTCs). Neurotrauma and RTCs are largely preventable, and many preventative strategies and interventions have been established and implemented over the last decades, particularly in high-income countries. However, these approaches may not be applicable globally, due to variations in environment, resources, population, culture and infrastructure. This paper outlines the protocol for a scoping review, which seeks to map the evidence on strategies and interventions in neurotrauma and RTCs prevention globally, and to ascertain contextual factors that influence their implementation.Methods and analysisThis scoping review will use the established methodology by Arksey and O’Malley. Eligible studies will be identified from five electronic databases (MEDLINE, EMBASE, CINAHL, Global Health/EBSCO and Cochrane Database of Systematic Reviews) and grey literature sources. We will also carry out bibliographical and citation searching of included studies. A two-stage selection process, which involves screening of titles and abstracts, followed by full-text screening, will be used to determine eligible studies which will undergo data abstraction using a customised, piloted data extraction sheet. The extracted data will be presented using evidence mapping and a narrative summary.Ethics and disseminationEthical approval is not required for this scoping review, which is the first step in a multiphase public health research project on the global prevention of neurotrauma. The final review will be submitted for publication to a scientific journal, and results will be presented at appropriate conferences, workshops and meetings. Protocol registered on 5 April 2019 with Open Science Framework (https://osf.io/s4zk3/).