bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyapihan Dini, Toilet Training dan Pola Asuh serta Pengaruhnya pada Temper Tantrum
Authors: Qurniyawati Eny , Ratnawati Riska 
Published: March 2020

Background: Child development includes physical, psychological and social aspects. The imbalance stimulation provided by parents could develop temper tantrum of child as a form of emotional explosion. The influence factors of tantrum among children are early weaning, improper toilet training, and the way of parenting in tantrum. This study aims to examine factors influence on temper tantrum among pre-school children. Method: This is descriptive analytical study with case control design. The number of case sample which selected from mothers who have tantrum pre-school child was 42 mothers and 42 control sample were also selected from mothers who have no tantrum child. Data were analyzed by univariate, bivariate (Chi-Square) and multivariate using logistic regression to examine the most influenced factors.Results: The study shows that early weaning, toilet training and parenting method were significantly influence on temper tantrum of pre-school children. The most influential variable was the parenting method with OR 9,09 and p-value 0,021. It means negative parenting method 9 times higher influence on tantrum temper behavior among children compared to positive parenting method. It is suggested that parenting method should emphasize more in educative and discipline including responsibility aspects.
AN EVENT AT THE DAWN OF MODERN KOREAN POETRY: KIM SOWOL’S “AZALEAS”
Authors: JEONG Myeong Kyo 
Published: March 2020

Kim Sowol is one of the Korean poets who opened the horizon of modern poetry in Korea. His poem, “Azaleas”(1925) has been known as a masterpiece which Korean people love most to recite as “To Cassandra” of Pierre de Ronsard in France. Nevertheless, this poem has been taken for the highest expression of the traditional sentiment without being appreciated for the quality of the modern poetry as follows: Koreans have sung for a long time the sorrow from the parting with the lover. In “Azaleas”, any reader can see easily the repeat of the same situation and same feeling.
In this article I analyzed the attitude and the intention of the speaker of this poem and reinterpret the theme of poem. In doing so, I found the clever strategy of the speaker in front of the irreversible situation to press secretly the reflection of the lover about his departure. This strategy is the invention of the modern [wo]man which can appropriate the crisis. So, I defined the modern characteristic of this poem and proved that this poem is not a repeated expression of the traditional feeling of the Koreans, but the de/re-construction of that.
Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances
Authors: Onasch Sebastian , Gjorgjieva Julijana 
Published: March 2020

Neurons and circuits each with a distinct balance of intrinsic and synaptic conductances can generate similar behavior but sometimes respond very differently to perturbation. Examining a large family of circuit models with non-identical neurons and synapses underlying rhythmic behavior, we analyzed the circuits' response to modifications in single and multiple intrinsic conductances in the individual neurons. To summarize these changes over the entire range of perturbed parameters, we quantified circuit output by defining a global stability measure. Using this measure, we identified specific subsets of conductances that when perturbed generate similar behavior in diverse individuals of the population. Our unbiased clustering analysis enabled us to quantify circuit stability when simultaneously perturbing multiple conductances as a nonlinear combination of single conductance perturbations. This revealed surprising conductance combinations that can predict the response to specific perturbations, even when the remaining intrinsic and synaptic conductances are unknown. Therefore, our approach can expose hidden variability in the balance of intrinsic and synaptic conductances of the same neurons across different versions of the same circuit solely from the circuit response to perturbations. Developed for a specific family of model circuits, our quantitative approach to characterizing high-dimensional degenerate systems provides a conceptual and analytic framework to guide future theoretical and experimental studies on degeneracy and robustness.SIGNIFICANCE STATEMENTNeural circuits can generate nearly identical behavior despite neuronal and synaptic parameters varying several-fold between individual instantiations. Yet, when these parameters are perturbed through channel deletions and mutations or environmental disturbances, seemingly identical circuits can respond very differently. What distinguishes inconsequential perturbations that barely alter circuit behavior from disruptive perturbations that drastically disturb circuit output remains unclear. Focusing on a family of rhythmic circuits, we propose a computational approach to reveal hidden variability in the intrinsic and synaptic conductances in seemingly identical circuits based solely on circuit output to different perturbations. We uncover specific conductance combinations that work similarly to maintain stability and predict the effect of changing multiple conductances simultaneously, which often results from neuromodulation or injury.
El Habeas Corpus como garantía constitucional para la protección de derechos fundamentales vulnerados por el hacinamiento carcelario
Authors: Londoño López Diana 
Published: March 2020

En el presente trabajo se analizó el Habeas Corpus como una garantía constitucional para la protección de derechos fundamentales vulnerados por el hacinamiento carcelario a la luz de la Ley Estatutaria 1095 de 2006. Para ello, se indagó acerca de la evolución histórica del Habeas Corpus, se analizó la normatividad nacional e internacional en concordancia con los pronunciamientos de la Corte Constitucional y se determinó el impacto del hacinamiento carcelario en los derechos fundamentales de los individuos privados de la libertad, mediante la exposición de tendencias de política criminal contemporánea (Política Criminal del Enemigo o Populismo Punitivo y Política Criminal Minimalista o de los Derechos Humanos). Igualmente, se realizó un análisis del hacinamiento carcelario en Colombia estudiando causas y efectos en la población privada de la libertad, apoyado en estadísticas entregadas por el INPEC.
EL PLURALISMO SOCIAL EN LA JURISPRUDENCIA DE LA CORTE CONSTITUCIONAL COLOMBIANA Y SUS EFECTOS EN MATERIA DE REALIZACIÓN DE LOS DERECHOS
Authors: Guarín Ramírez Edgar , Olarte López Luisa , Garzón Barrera Juan 
Published: March 2020

A partir de los desarrollos en torno al concepto de pluralismo social, el alto tribunal de lo constitucional en Colombia ha abierto la puerta al reconocimiento de derechos a sectores de la población que durante mucho tiempo fueron excluidos: indígenas, afrodescendientes, comunidades rom, etc. Empero, dichos desarrollos también han conducido a hacer una defensa de las convicciones personales de cada individuo -erigidas como derechos a través del concepto de libre desarrollo de la personalidad- cuyo ejercicio, en ocasiones, interfiere con derechos de otras personas legítimamente constituidos, lo cual es causa de confrontación social. Los enconados debates en casos como los de la eutanasia, el aborto, las uniones de parejas del mismo sexo, la dosis personal, entre otros, son muestra de ello. Jurídicamente la problemática se relaciona con temas que refieren al concepto mismo de derecho y los elementos que le estructuran, la recta administración de justicia, el papel de los jueces constitucionales y la conservación del orden social como un bien común.
Genetic Antibiotic Resistance of Helicobacter pylori in South-Eastern Romania
Authors: Dumitru Eugen , Alexandrescu Luana , Hanu Anda Carmen , Tocia Cristina , Cozaru Georgeta Camelia , Mitroi Anca Florentina , Brînzan Costel , Așchie Mariana , Dumitru Irina Magdalena 
Published: March 2020

Background and Aim. Helicobacter pylori infection is very common worldwide, and it is associated with an important gastric pathology. Treatment of this infection is difficult and consists of the combination of two or three antibiotics. However, the rate of resistance to treatment is high. Antimicrobial resistance of Helicobacter pylori is based on its cultivation in the laboratory and testing of phenotypic susceptibility, a time-consuming, laborious method. This study aimed to detect the genetic resistance to antibiotics of Helicobacter pylori in the south-eastern region of Romania.
Methods. Ninety patients with positive rapid urease test gastric biopsy samples were tested. Genetic resistance to antibiotics (fluoroquinolone and clarithromycin) was tested by GenoType HelicoDR kit (Hain Lifescience GmbH, Germany).
Results. Clarithromycin resistance mutations were detected in 20% of patients, the commonest mutation in our study beeing A2147G (associated with high level of clarithromycin resistance and lower cure rates). Fluoroquinolones resistance mutations were detected in 30% of patients, and the most common mutations were D91N, D91G, and N87K. There was no correlation with patients gender or age, with the exception of fluoroquinolone resistance, which was detected more frequently in females.
Conclusions. Clarithromycin and fluoroquinolone resistance of Helicobacter pylori is moderately high in our study. There is a need for monitoring Helicobacter resistance patterns in Romania to provide data that can guide empirical treatment. This is the first published study on the genetic resistance of Helicobacter pylori in Romania.
Hormone Receptor–Positive/Human Epidermal Growth Receptor 2–Negative Metastatic Breast Cancer in Young Women: Emerging Data in the Era of Molecularly Targeted Agents
Authors: Shah Ami N. , Metzger Otto , Bartlett Cynthia Huang , Liu Yuan , Huang Xin , Cristofanilli Massimo 
Published: March 2020

AbstractBreast cancer is the most common malignancy in young women worldwide, accounting for an estimated 30% of new cancer diagnoses and 25% of cancer deaths. Approximately two thirds of young women with breast cancer have hormone receptor–positive (HR+)/human epidermal growth receptor 2–negative (HER2−) tumors. Numerous studies, primarily in early-stage breast cancer, have demonstrated that young age is an independent risk factor for more aggressive disease and worse outcomes. Although more limited data are available regarding outcomes in young patients with advanced disease, these age-related disparities suggest that breast cancer in premenopausal women has distinct clinicopathologic and molecular features that can impact treatment outcomes. Until recently, limited data were available on the intrinsic molecular subtypes and genetics of young patients with HR+/HER2− metastatic breast cancer (mBC). In this review, we explore insights into the clinical and pathologic features of HR+/HER2− mBC in younger women derived from recent clinical trials of the cyclin-dependent kinase 4/6 inhibitors palbociclib (PALOMA-3), ribociclib (MONALEESA-7), and abemaciclib (MONARCH 2) and the implications of these findings for clinical practice, guideline development, and future research.Implications for PracticeThis review provides clinicians with an overview of emerging data on the unique clinicopathologic and molecular features of hormone receptor–positive/human epidermal growth receptor 2–negative metastatic breast cancer (mBC) in premenopausal women, summarizes findings from the most recent clinical trials of endocrine-based treatment in this patient population, and explores the implications of these findings for clinical practice, guideline development, and future research. Improved understanding of the key factors influencing disease course and treatment response in premenopausal patients with mBC may lead to more timely incorporation of evidence-based treatment approaches, thereby improving patient care and outcomes.
Anemia, iron status, and associated protective and risk factors among children and adolescents aged 3 to 19 years old from four First Nations communities in Quebec
Authors:   Community of Winneway - Long Point First Nation, Community of Lac Simon, CSSS Tshukuminu Kanani of Nutashkuan, Community of Unamen Shipu, Tahir Emad , Ayotte Pierre , Little Matthew , Bélanger Richard E. , Lucas Michel , Mergler Donna , Laouan Sidi Elhadji A. , McHugh Nancy Gros-Louis , Lemire Mélanie 
Published: March 2020

AbstractObjectivesAnemia and iron deficiency (ID) are frequent among Indigenous children of Canada, but few data are available in Quebec. The present study aimed to characterize anemia and ID prevalence and associated protective and risk factors among First Nations youth in Quebec.MethodsThe 2015 First Nations (JES!-YEH!) pilot study was conducted among children and adolescents (3 to 19 years; n = 198) from four First Nations communities in Quebec. Blood and urine samples and anthropometric measurements were collected. Hemoglobin (Hb), serum ferritin (SF), plasma hs-CRP, and urinary cotinine levels were measured. Factors associated with anemia and ID (including traditional and market food consumption) were assessed using an interview-administered food frequency questionnaire, based on which nutritional intakes were calculated. Structural equation models were used to test associations.ResultsThe prevalence of anemia and ID was elevated (16.8% and 20.5% respectively). Traditional meat, fruit, and fruit juice (natural and powdered)—via their positive association with vitamin C intake—were the only food variables positively associated with SF (coefficient [95% CI] 0.017 [0.000, 0.114]; 0.090 [0.027, 0.161]; and 0.237 [0.060, 0.411]). Male sex was also associated with higher SF (0.295 [0.093, 0.502]). Inflammation status (hs-CRP > 5 mg/L) was inversely associated with Hb (− 0.015 [− 0.025, − 0.005]), whereas SF was positively associated with Hb (0.066 [0.040, 0.096]). Fruit and juice consumption was also positively associated with Hb, via vitamin C intake and SF (0.004 [0.001, 0.010]; 0.008 [0.003, 0.017]).ConclusionsInterventions fostering healthier food environments as well as higher consumption of traditional meats and foods naturally rich in vitamin C, which is known to enhance iron absorption, and fighting inflammation could contribute to decrease the high prevalence of anemia and ID in this young Indigenous population.
Social connection as a public health adaptation to extreme heat events
Authors: Kafeety Amani , Henderson Sarah B. , Lubik Amy , Kancir Jesse , Kosatsky Tom , Schwandt Michael 
Published: March 2020

AbstractClimate change is an increasingly important public health issue, reflected in morbidity and mortality outcomes during extreme heat events. At the same time, the harms of social isolation with respect to a wide range of health outcomes are becoming better understood. Given that older adults are at higher risk during hot weather and at higher risk of social isolation, they are among those at highest risk for adverse impacts of extreme heat events. While specific strategies to reduce heat exposure have been described in the literature and promoted in public health practice, these may not be readily available to socially isolated older adults. As such, it is crucial to identify key approaches to address risk due to social isolation in the aging population, and to acknowledge their limitations and barriers. Interventions rooted in social connection, a concept widely applied in interventions for public health and social well-being, should be applied as a tool for adaptation to extreme heat events.
Prevalence of vitamin D and B12 deficiency in pregnant women in Jammu, India
Authors: Kaur Sapneet , Kaur Harleen 
Published: March 2020

Background: Micronutrient deficiency is pandemic proportions among pregnant women in India, but there is scarcity of searchable data on coexistence vitamin D status and Vitamin B 12 in pregnant women in Jammu and Kashmir, hence we have assessed the vitamin D as well as Vitamin B12 status in pregnant women attending outpatient department in a tertiary care hospital Jammu.Methods: The study was conducted in the department of Biochemistry Government Medical College Jammu during June 2019 to February, 2020 and after obtaining informed consent, a total of 150 pregnant women, attending SMGS Hospital Jammu were screened for their vitamin D (25 OH-D) and vitamin B12 status by using Abbott architect chemiluminescent micro particle immunoassay.Results: A total of 150 pregnant women were screened in the study , 129 (86%) were found to be having insufficient vitamin D levels in their blood (<30 ngm/dl) and 105 ( 70%) women showed severe deficiency with vitamin D levels below 20 ngm/dl.108 (72%) pregnant women had vitamin B12 deficiency with levels below 200 pgm/ml.Conclusions: The study revealed a high prevalence of coexistence of Vitamin D and Vitamin B12 deficiency in pregnant women, despite of abundant sunshine throughout the year and also with the consideration that people of this region are well off economically and can afford good nutrition.
Morphological and histological variations in livers and its embryological correlation
Authors: Srivastava Stuti , Zubair Khan Abeer 
Published: March 2020

To study the variations in gross morphology and any change in histological architecture in cadaveric liver specimens and correlate with development in intrauterine life.The livers were obtained from the cadavers during dissection and museum in the department of Anatomy, MCI recognized private medical college in North India. The morphological and histological observations were documented.Morphological variations were observed and classified. Histologically all specimens appeared to be normal.The knowledge of such variations is important to anatomists, morphologists and embryologists for developmental anomalies. This will be beneficial for the surgeons for planning surgery involving liver and radiologists for interpretation of CT scans and MRI images.
Evaluation of thyroid profile and renal function tests in chronic kidney disease patients
Authors: L Manohari A , Pathan Firoz 
Published: March 2020

Chronic kidney disease (CKD) is a global epidemic condition and nowadays it has become a major public health concern imposing huge socioeconomic burden. In patients of CKD patients thyroid profile gets deranged due to abnormal metabolism in the thyroid hormones.The present study was planned to evaluate the thyroid hormones T3, T4, TSH ,blood urea and serum creatinine levels as markers of renal function inpatients of CKD.In the present case control study, 37 patients with CKD with and without hemodialysis and 30 healthy age and sex matched controls were enrolled to evaluate the thyroid dysfunction and renal function tests. Cases fulfilling inclusion criteria attending Nephrology Department and Dialysis unit in King George hospital, Visakhapatnam were included in the study.In this study, out of 37 cases 27 CKD patients were having treatment without dialysis and 10 CKD patients were on hemodialysis. 3(11%) cases out of 27 CKD patients without hemodialysis were observed to be hypothyroid and 3(30%) cases out of 10 CKD on hemodialysis were hypothyroid. The incidence of hypothyroidism is 16.2% in CKD patients.In our study, the difference in mean values of T3 was statistically significant in cases compared to controls unlike T4 and TSH which indicates association of lower T3 syndrome with CKD.
Does Fetal Gender Really Affects Neonatal Birth Weight and Gestational Age at Birth? A Prospective Cohort Study
Authors: Kumar Naina , Yadav Ashu 
Published: March 2020

OBJECTIVEThe objective of this study was to understand the impact of fetal gender on neonatal birth weight for the gestational age at the time of birth. Only neonates with a gestational age of 28 weeks or more than 28 weeks were included in the study.METHODSThis prospective study was conducted within the Obstetrics and Gynecology Department of a rural tertiary center in Northern India. The study was conducted after ethical clearance and informed consent from participants who fulfilled the inclusion criteria. Data collection included neonatal gender, birth weight, Apgar scores, and gestational age. Neonates were delivered vaginally or by cesarean section at 28 or more weeks of gestation. Statistical analysis was done using version SPSS-22 software.RESULTSOf 2,997 live fetuses, 1,574 (52.5%) were male, 1,421 (47.4%) were female, and 2 (0.07%) had ambiguous genitalia. Mean ± standard deviation (SD) for male neonate's birth weight was 2.79 ± 0.503 kg (95% confidence interval [CI]: 2.76–2.81), for females 2.67 ± 0.485 kg (95% CI: 2.64–2.69) respectively (p = .000). Males had lower Apgar scores at 1 and 5 minutes of age compared to females (7.06 ± 0.859, 8.83 ± 0.838 vs. 7.12 ± 0.645, 8.88 ± 0.612). There were no significant difference between fetal gender and gestational age at birth (18% females were preterm vs. 15.4% males, 81.8% females were term vs. 84.2% males, 0.1% females post-term vs. 0.4% males; p = .079).CONCLUSIONFetal gender was related to birth weight. Male neonates had a higher birth weight, but lower Apgar scores than female neonates. Fetal gender was not correlated with gestational age at the time of birth.
Exploratory and Confirmatory Factor Analysis of the Maslach Burnout Inventory to Measure Burnout Syndrome in Critical Care Nurses
Authors: Schneider Alexandra , Forster Jeri E. , Mealer Meredith 
Published: March 2020

Background and PurposeBurnout syndrome is common in critical care nursing. The Critical Care Societies Collaborative recently released a joint statement and call to action on burnout in critical care professionals.MethodsWe conducted an exploratory factor analysis and confirmatory factor analysis (CFA) of the 22-item MBI.ResultsThe exploratory factor analysis identified three factors but after questions were removed; we were left with a 2-factor, 10-item abridged version of the MBI-HSS to test with CFA modeling. The CFA indicated conflicting fit indices.Conclusionswe conducted an exploratory and CFA of the abridged MBI-HSS in critical care nurses from the United States and found the two-factor model was the best fit achieved.
Development of the Pediatric Advanced Life Support Skills Self-Efficacy Inventory to Assess Rural Healthcare Providers
Authors: Stellflug Stacy M. , Lowe Nancy K. 
Published: March 2020

Background and PurposeRural healthcare provider's willingness to implement pediatric resuscitation may be impeded by comfort level. The purpose of this study was to evaluate the psychometric properties of the Pediatric Advanced Life Support Skill Self-Efficacy Inventory (PALS-SSEI).MethodsA 19-item inventory was created based on PALS skills. The PALS-SSEI was completed by 94 participants in a study to test the effects of simulation training on PALS knowledge and skill.ResultsSix clinical content experts rated the content validity of the PALS-SSEI as high. Item and factor analysis supported the tool's construct validity. A Cronbach's alpha coefficient of 0.88 supported the internal consistency of the tool.ConclusionsThe PALS-SSEI demonstrated good initial psychometric properties. The tool can be used to assess self-efficacy for PALS skills among healthcare providers.