bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical properties of zirconia octet truss structures fabricated by DLP 3D printing
Authors: Zhao Weiming , Wang Cao , Xing Bohang , Shen Minhao , Zhao Zhe 
Published: July 2020

Abstract
Zirconia ceramic octet-truss structures with various strut size and unit cell numbers were successfully fabricated through a DLP-based 3D printing method. The mechanical properties and energy absorption capacity under compressive load were investigated systematically. The sides of all cubes are 10 mm, the strut size was changed from 0.25 mm to 2 mm, cells number was in the range of 1(1 × 1 × 1)–125(5 × 5 × 5). It has been seen that the relative density, compressive strength and energy absorption increases with the increase of strut size when cell numbers remain the same. It can be concluded that the strength and energy absorption were affected by the relative density, strut size and the stacking mode of the unit cells. So far, with this study, a high compressive strength of 75.3 MPa and a reasonably good energy absorption of 6.76 × 105 J m−3 can be achieved at a relative density of 48.57%.
Estimation of short-circuit current induced by ELF uniform electric fields in grounded humans with different body shapes based on a semi-ellipsoidal model
Authors: Tarao Hiroo , Hayashi Noriyuki , Isaka Katsuo 
Published: July 2020

Abstract
It has been reported that when a grounded human is exposed to an electric field at power frequency, a short-circuit current flowing from the feet to the ground is proportional to the square of his or her height. The current, however, should also vary with the body surface area, that is, body shape, even in people with the same height. In the present study, we confirmed this hypothesis using an analytical solution derived from a semi-ellipsoidal model. The short-circuit currents were calculated for various numerical human body models in which the horizontal length of a voxel was varied from 1.8 to 3.0 mm, and the results for different body shapes were compared. Finally, we derived an approximate expression for estimating the short-circuit current from the left-right width (2b), frontal thickness (2c), and height (a) of a human from the analytical solution. The short-circuit currents obtained from the approximate expression are consistent with those obtained from numerical calculations for 48 differently shaped human body models with a correlation coefficient of 0.9942. Hence, we concluded that the short-circuit current can be determined depending on the similarity ratio (a/b) and the ellipticity ratio (c/b) of the human body as well as the height. This finding is consistent with the numerical human body models that have been used previously, in which the similarity and ellipticity ratios were very close. Therefore, we can make the limited conclusion that the short-circuit current is proportional only to the square of the height. Additionally, numerical calculations showed that the short-circuit current is the same whether one foot or both feet are grounded.
Characterization of novel polydiacetylene gel dosimeter for radiotherapy
Authors: Walg Y Peleg , Silveira M A , Eafergan N , Krutman Y , Baffa O , Berman A , Orion I 
Published: July 2020

Abstract
Polymer gel dosimeters are instrumental for clinical and research applications in radiotherapy. These dosimeters possess the unique ability to record dose distribution in three dimensions. A Polymer gel dosimeter is composed of organic molecules in a gel matrix, which upon irradiation polymerize to form a conjugated polymer with optical absorbance proportional to the irradiated dose. Other required characteristics of a radiotherapy clinical dosimeter are soft-tissue equivalency, linear dose-response in a range of clinical treatments, and long term stability for the duration of the analysis. The dosimeter presented in this paper is based on diacetylene bearing fatty acid aggregates embedded in a soft-tissue equivalent gel matrix, Phytagel™, which upon irradiation polymerize to form a blue phase polydiacetylene with a strong optical absorption. Initial characterization showed that PDA-gel irradiated with 160 kV x-ray responded linearly to the irradiated dose, and the calculated diffusion coefficient is

6
·

10

−
3

mm

2

Hr

what is very low. It was also found that the percentage depth dose (PDD) curve of the PDA-gel in a 4 × 4 cm2 field, irradiated with 6 MV x-rays, was with good agreement with the literature. PDA-gel has the potential to detect absorbed dose in a range of clinical radiological irradiation regimes.
Amplified propagating plasmon in asymmetrical graphene periodic structure
Authors: Moiseenko I M , Popov V V , Fateev D V 
Published: July 2020

Abstract
The excitation and amplification of the propagating plasmons in a periodic active (with population inversion of charge carriers) graphene-based structure with dual grating-gate with an asymmetric unit cell is studied theoretically. Such structure transforms the normally incident THz electromagnetic wave into sustained or amplified unidirectionally propagating plasmon. This effect is caused by simultaneous excitation of radiative and ‘non-radiative’ plasmon modes at the same frequency.
Highly concentrated atmospheric inorganic nitrogen deposition in an urban, coastal region in the US
Authors: Joyce Emily E , Walters Wendell W , Le Roy Emmie , Clark Sydney C , Schiebel Hayley , Hastings Meredith G 
Published: July 2020

Abstract
Much of our understanding of atmospheric nitrogen deposition (AD) is based on important monitoring networks, such as the National Atmospheric Deposition Program (NADP) in the United States (US). However, it is likely that rural-based monitoring data are unrepresentative of reactive nitrogen concentrations found in urban areas. In this study, event-based precipitation was collected over one-year in Providence, RI - a mid-sized city situated at the head of Narragansett Bay, the largest estuary in the northeastern US Significant concentration enhancements in inorganic nitrogen (i.e., ammonium and nitrate) were found for wet deposition in the urban area compared to nearby NADP rural and non-urban coastal monitoring sites. Moreover, the annual ratio of ammonium to nitrate was highest in urban precipitation (>1.0). From 164 precipitation events, the mean volume-weighted ammonium and nitrate concentrations were 32.9 μmol l−1 and 28.4 μmol l−1, respectively, with total inorganic nitrogen concentrations exceeding 100 μmol l−1 in at least 30 events. AD data for Narragansett Bay is limited and outdated: our results suggest inorganic nitrogen is at least 2.5 times greater than currently estimated in policy decision-making related to improving water quality and ecosystem services. This underestimation is due to an increase (by as much as 6 times) in ammonium wet deposition since 1990, likely due to an increase in urban sources of precursor ammonia.
Spike-based information encoding in vertical cavity surface emitting lasers for neuromorphic photonic systems
Authors: Hejda Matěj , Robertson Joshua , Bueno Julián , Hurtado Antonio 
Published: July 2020

Abstract
The ongoing growth of use-cases for artificial neural networks (ANNs) fuels the search for new, tailor-made ANN-optimized hardware. Neuromorphic (brain-like) computers are among the proposed highly promising solutions, with optical neuromorphic realizations recently receiving increasing research interest. Among these, photonic neuronal models based on vertical cavity surface emitting lasers (VCSELs) stand out due to their favourable properties, fast operation and mature technology. In this work, we experimentally demonstrate different strategies to encode information into ultrafast spiking events in a VCSEL-neuron. We evaluate how the strength of the input perturbations (stimuli) influences the spike activation time, allowing for spike latency input coding. Based on a study of refractory behaviour in the system, we demonstrate the capability of the VCSEL-neuron to perform reliable binary-to-spike information coding with spiking rates surpassing 1 GHz. We also report experimentally on neuro-inspired spike firing rate-coding with a VCSEL-neuron, where the strength of the input perturbation (stimulus) is continuously encoded into the spiking frequency (spike firing rate). With the prospects of neuromorphic photonic systems constantly growing, we believe the reported functionalities with the ultrafast spiking VCSEL-neurons provide a reliable, multifaceted approach for interfacing photonic neuromorphic platforms with existing computation and communication systems.
Fabrication of bulk heterojunction organic solar cells with different configurations using electrospray
Authors: Shah S K 
Published: July 2020

Abstract
In this work, we fabricated bulk heterojunction (BHJ) organic solar cells (OSCs) using electrospray deposition (ESD) with two different device configurations. ITO/PEDOT:PSS/P3HT: PCBM/Ca/Al and ITO/ZnO and TiO2/P3HT: PCBM/MoO3/Ag, termed as direct and inverted OSCs, respectively. In ZnO/ TiO2 -based inverted solar cells, ZnO/ TiO2 films were synthesized by sol-gel process and deposited on ITO deposited glass substrates using the spin-coating technique. P3HT/PCBM blend layers were deposited by using electrospray deposition (ESD). To observe the thermal effects on the device efficiencies, the devices were annealed at different temperatures (up to 140 °C). The cell’s performance parameters were compared at an annealing temperature of 120 °C. Comparing the performance parameters of both types of OSCs at an annealing temperature of 120 °C, the power conversion efficiency (PCE) the 1.62% is found for direct-structured OSC while 1.57% and 1.0% for ZnO/ TiO2-based inverted structures, respectively. Interestingly, the enhanced device performance parameters were obtained with oxides-based OSCs. Compared to ZnO-based inverted OSC, the TiO2-based inverted OSC has lower efficiency which might be due to the highly resistive surface of TiO2 with deep-level traps. These traps can be reduced by light soaking to achieve the optimal power conversion efficiency.
Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology
Authors: Tanabe Sean , Bo Amber , White Marissa , Parker Margaret , Farahbakhsh Zahra , Ballweg Tyler , Casey Cameron , Betthauser Tobey , Zetterberg Henrik , Blennow Kaj , Christian Brad , Bendlin Barbara B , Johnson Sterling , Sanders Robert D 
Published: July 2020

Abstract
Electroencephalography signatures of amyloid-β, tau and neurodegenerative pathologies would aid in screening for, tracking progression of, and critically, understanding the pathogenesis of dementia. We hypothesized that slowing of the alpha peak frequency, as a signature of hyperpolarization-activated cyclic nucleotide gated ‘pacemaker’ channel activity, would correlate with amyloid and tau pathology burden measured by amyloid (Pittsburgh Compound B) and tau (MK-6240) positron emission tomography or CSF biomarkers. We also hypothesized that EEG power would be associated with neurodegeneration (CSF neurofilament light and hippocampal volume). Wakeful high-density EEG data were collected from 53 subjects. Both amyloid-β and tau pathology were associated with slowing in the alpha peak frequency [Pittsburgh Compound B (+) vs. Pittsburgh Compound B (−) subjects, P = 0.039 and MK-6240 (+) vs. MK-6240 (−) subjects, P = 0.019]. Furthermore, slowing in the peak alpha frequency correlated with CSF Aβ42/40 ratio (r2 = 0.270; P = 0.003), phosphoTau (pTau181, r2 = 0.290; P = 0.001) and pTau181/Aβ42 (r2 = 0.343; P &lt; 0.001). Alpha peak frequency was not associated with neurodegeneration. Higher CSF neurofilament light was associated with lower total EEG power (r2 = 0.136; P = 0.018), theta power (r2 = 0.148; P = 0.014) and beta power (r2 = 0.216; P = 0.002); the latter was also associated with normalized hippocampal volume (r2 = 0.196; P = 0.002). Amyloid-tau and neurodegenerative pathologies are associated with distinct electrophysiological signatures that may be useful as mechanistic tools and diagnostic/treatment effect biomarkers in clinical trials.
Identifying Optimal Loci for the Molecular Diagnosis of Microsatellite Instability
Authors: Long Dustin R , Waalkes Adam , Panicker Varun P , Hause Ronald J , Salipante Stephen J 
Published: July 2020

AbstractBackgroundMicrosatellite instability (MSI) predicts oncological response to checkpoint blockade immunotherapies. Although microsatellite mutation is pathognomonic for the condition, loci have unequal diagnostic value for predicting MSI within and across cancer types.MethodsTo better inform molecular diagnosis of MSI, we examined 9438 tumor-normal exome pairs and 901 whole genome sequence pairs from 32 different cancer types and cataloged genome-wide microsatellite instability events. Using a statistical framework, we identified microsatellite mutations that were predictive of MSI within and across cancer types. The diagnostic accuracy of different subsets of maximally informative markers was estimated computationally using a dedicated validation set.ResultsTwenty-five cancer types exhibited hypermutated states consistent with MSI. Recurrently mutated microsatellites associated with MSI were identifiable in 15 cancer types, but were largely specific to individual cancer types. Cancer-specific microsatellite panels of 1 to 7 loci were needed to attain ≥95% diagnostic sensitivity and specificity for 11 cancer types, and in 8 of the cancer types, 100% sensitivity and specificity were achieved. Breast cancer required 800 loci to achieve comparable performance. We were unable to identify recurrent microsatellite mutations supporting reliable MSI diagnosis in ovarian tumors. Features associated with informative microsatellites were cataloged.ConclusionsMost microsatellites informative for MSI are specific to particular cancer types, requiring the use of tissue-specific loci for optimal diagnosis. Limited numbers of markers are needed to provide accurate MSI diagnosis in most tumor types, but it is challenging to diagnose breast and ovarian cancers using predefined microsatellite locus panels.
Similar Long-Term Outcomes in Children Presenting With Abscess vs Phlegmon at Diagnosis of Crohn Disease
Authors: Fondell Andrew W , Mosha Maua H , Maltz Ross M , Boyle Brendan M , Niklinska-Schirtz Barbara Joanna , Kugathasan Subra , Gibson Meghan E , Shapiro Jason M , Rosenheck Sarah M , Langseder Annette L , Kennedy Mary C , Rosh Joel R , Hyams Jeffrey S 
Published: July 2020

AbstractBackgroundLimited data are available for long-term outcomes of pediatric patients with abdominal abscess or phlegmon at diagnosis of Crohn disease.MethodsWe performed a retrospective chart review of such children over a recent 6-year period at 5 pediatric inflammatory bowel diseases.ResultsFifty-two patients (mean age 15.9 ± 1.8 years) were reviewed. Thirty-six had an abscess and 27 (75%) required resectional therapy compared to 16 with phlegmon which 10 (63%) requiring surgery. Overall (37/52) 71% had surgery which was performed within 6 months in 32 (86%).ConclusionsA similar high surgical rate exists whether pediatric patients with Crohn disease present with abscess or phlegmon.
Percutaneous left ventricular endocardial leads: adverse outcomes and a percutaneous extraction case series
Authors: Behar Jonathan M , Finlay Malcolm C , Rowland Edward , Ezzat Vivienne , Sporton Simon , Dhinoja Mehul 
Published: July 2020

Abstract

Background
Conventional cardiac resynchronization therapy (CRT) involves the placement of an epicardial left ventricular (LV) lead through the coronary venous tree. However, alternative approaches of delivering CRT have been sought for patients who fail to respond to conventional methods or for those where coronary venous anatomy is unfavourable. Biventricular pacing through an endocardial LV lead has potential advantages; however, the long-term clinical and safety data are not known.

Case summary
This article details a case series of four patients with endocardial LV leads; three of these for previously failed conventional CRT and a fourth for an inadvertently placed defibrillator lead.

Discussion
We describe the clinical course and adverse events associated with left-sided leads and subsequently describe the safe and feasible method of percutaneous extraction.
The Role of Reciprocity in the Creation of Reputation
Authors: Abraham Martin , Damelang Andreas , Grimm Veronika , Neeß Christina , Seebauer Michael 
Published: July 2020

AbstractAlthough reputation has been shown to solve problems of information and opportunism in business relationships, knowledge of the emergence of reputation in business relationships beyond the internet is considerably scarcer. In this article, we argue that in social and economic systems, a norm of reciprocity is an important driver for the transfer of reputation information. A social norm to return favours given by others enhances the flow of information about potential exchange partners. We distinguish between direct and generalized reciprocity and argue that both may foster the flow of information about exchange partners in economic systems. Moreover, we examine the interdependency between competition and reciprocity. Our empirical evidence is based on a laboratory experiment with students and a factorial survey experiment with 209 managers from a German business cluster. Our results show that direct reciprocity, in particular, is an important driver of the transmission of reputation information to third parties. Moreover, in an exchange system, transmission costs and competition reduce the willingness to produce reputation information.
Can QRS morphology be used to differentiate between true septal vs. apparently septal lead placement? An analysis of ECG of real mid-septal, apparent mid-septal, and apical pacing
Authors: Mala Anna , Osmancik Pavel , Herman Dalibor , Curila Karol , Stros Petr , Vesela Jana , Prochazkova Radka , Petr Robert 
Published: July 2020

Abstract
The location of the pacemaker lead is based on the shape of the lead on fluoroscopy only, typically in the left and right anterior oblique positions. However, these fluoroscopy criteria are insufficient and many leads apparently considered to be in septum are in fact anchored in anterior wall. Periprocedural ECG could determine the correct lead location. The aim of the current analysis is to characterize ECG criteria associated with a correct position of the right ventricular (RV) lead in the mid-septum. Patients with indications for a pacemaker had the RV lead implanted in the apex (Group A) or mid-septum using the standard fluoroscopic criteria. The exact position of the RV lead was verified using computed tomography. Based on the findings, the mid-septal group was divided into two subgroups: (i) true septum, i.e. lead was found in the mid-septum, and (ii) false septum, i.e. lead was in the adjacent areas (anterior wall, anteroseptal groove). Paced ECGs were acquired from all patients and multiple criteria were analysed. Paced ECGs from 106 patients were analysed (27 in A, 36 in true septum, and 43 in false septum group). Group A had a significantly wider QRS, more left-deviated axis and later transition zone compared with the true septum and false septum groups. There were no differences in presence of q in lead I, or notching in inferior or lateral leads between the three groups. QRS patterns of true septum and false septum groups were similar with only one exception of the transition zone. In the multivariate model, the only ECG parameters associated with correct lead placement in the septum was an earlier transition zone (odds ratio (OR) 2.53, P = 0.001). ECGs can be easily used to differentiate apical pacing from septal or septum-close pacing. The only ECG characteristic that could help to identify true septum lead position was the transition zone in the precordial leads.
ClinicalTrials.gov identifier: NCT02412176.
Gut microbiota in a host–brood parasite system: insights from common cuckoos raised by two warbler species
Authors: Schmiedová Lucie , Kreisinger Jakub , Požgayová Milica , Honza Marcel , Martin Jean-François , Procházka Petr 
Published: July 2020

ABSTRACTAn animal's gut microbiota (GM) is shaped by a range of environmental factors affecting the bacterial sources invading the host. At the same time, animal hosts are equipped with intrinsic mechanisms enabling regulation of GM. However, there is limited knowledge on the relative importance of these forces. To assess the significance of host-intrinsic vs environmental factors, we studied GM in nestlings of an obligate brood parasite, the common cuckoo (Cuculus canorus), raised by two foster species, great reed warblers (Acrocephalus arundinaceus) and Eurasian reed warblers (A. scirpaceus), and compared these with GM of the fosterers’ own nestlings. We show that fecal GM varied between cuckoo and warbler nestlings when accounting for the effect of foster/parent species, highlighting the importance of host-intrinsic regulatory mechanisms. In addition to feces, cuckoos also expel a deterrent secretion, which provides protection against olfactory predators. We observed an increased abundance of bacterial genera capable of producing repulsive volatile molecules in the deterrent secretion. Consequently, our results support the hypothesis that microbiota play a role in this antipredator mechanism. Interestingly, fosterer/parent identity affected only cuckoo deterrent secretion and warbler feces microbiota, but not that of cuckoo feces, suggesting a strong selection of bacterial strains in the GM by cuckoo nestlings.
Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins
Authors: Horton Maurice , Su Guowei , Yi Lin , Wang Zhangjie , Xu Yongmei , Pagadala Vijayakanth , Zhang Fuming , Zaharoff David A , Pearce Ken , Linhardt Robert J , Liu Jian 
Published: July 2020

AbstractHeparan sulfate (HS) is a heterogeneous, extracellular glycan that interacts with proteins and other molecules affecting many biological processes. The specific binding motifs of HS interactions are of interest, but have not been extensively characterized. Glycan microarrays are valuable tools that can be used to probe the interactions between glycans and their ligands while relying on relatively small amounts of samples. Recently, chemoenzymatic synthesis of HS has been employed to produce specific HS structures that can otherwise be difficult to produce. In this study, a microarray of diverse chemoenzymatically synthesized HS structures was developed and HS interactions were characterized. Fluorescently labeled antithrombin III (AT) and fibroblast growth factor-2 (FGF2) were screened against 95 different HS structures under three different printing concentrations to confirm the utility of this microarray. Specific sulfation patterns were found to be important for binding to these proteins and results are consistent with previous specificity studies. Furthermore, the binding affinities (KD,surf) of AT and FGF2 to multiple HS structures were determined using a microarray technique and is consistent with previous reports. Lastly, the 95-compound HS microarray was used to determine the distinct binding profiles for interleukin 12 and platelet factor 4. This technique is ideal for rapid expansion and will be pivotal to the high-throughput characterization of biologically important structure/function relationships.