bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amazonia trees have limited capacity to acclimate plant hydraulic properties in response to long‐term drought
Authors: Bittencourt Paulo R. L. , Oliveira Rafael S. , da Costa Antonio C. L. , Giles Andre L. , Coughlin Ingrid , Costa Patricia B. , Bartholomew David C. , Ferreira Leandro V. , Vasconcelos Steel S. , Barros Fernanda V. , Junior Joao A. S. , Oliveira Alex A. R. , Mencuccini Maurizio , Meir Patrick , Rowland Lucy 
Published: February 2020

AbstractThe fate of tropical forests under future climate change is dependent on the capacity of their trees to adjust to drier conditions. The capacity of trees to withstand drought is likely to be determined by traits associated with their hydraulic systems. However, data on whether tropical trees can adjust hydraulic traits when experiencing drought remain rare. We measured plant hydraulic traits (e.g. hydraulic conductivity and embolism resistance) and plant hydraulic system status (e.g. leaf water potential, native embolism and safety margin) on >150 trees from 12 genera (36 species) and spanning a stem size range from 14 to 68 cm diameter at breast height at the world's only long‐running tropical forest drought experiment. Hydraulic traits showed no adjustment following 15 years of experimentally imposed moisture deficit. This failure to adjust resulted in these drought‐stressed trees experiencing significantly lower leaf water potentials, and higher, but variable, levels of native embolism in the branches. This result suggests that hydraulic damage caused by elevated levels of embolism is likely to be one of the key drivers of drought‐induced mortality following long‐term soil moisture deficit. We demonstrate that some hydraulic traits changed with tree size, however, the direction and magnitude of the change was controlled by taxonomic identity. Our results suggest that Amazonian trees, both small and large, have limited capacity to acclimate their hydraulic systems to future droughts, potentially making them more at risk of drought‐induced mortality.
Prognostic impact of combined progression index based on peritoneal grading regression score and peritoneal cytology in peritoneal metastasis
Authors: Benzerdjeb Nazim , Durieux Emeline , Tantot Juliet , Isaac Sylvie , Fontaine Juliette , Harou Olivier , Glehen Olivier , Kepenekian Vahan , Alyami Mohammad , Villeneuve Laurent , Laplace Nathalie , Traverse‐Glehen Alexandra , Shisheboran‐Devouassoux Mojgan , Bakrin Naoual 
Published: February 2020

AimsThe peritoneal regression grading score (PRGS) and peritoneal cytology (PC) assess response to chemotherapy in peritoneal metastasis (PM) in a setting of palliative treatment by pressurized intraperitoneal aerosol chemotherapy (PIPAC). Progression has been defined as an increase of PRGS between first and third PIPAC procedures (iPRGS). iPRGSand positive peritoneal cytology were not associated with prognostic impact. These results may be explained by a lack of statistical power. Also, it is not known whether the mean or the highest PRGS among taken peritoneal biopsies bears the highest clinical value. We therefore conducted the largest prospective study to investigate the prognostic impact of PGRS, PC, and their combination, designated as combined progression index (CPI).Methods and resultsPatients with PM who underwent >3 PIPAC (n = 112) between December 2016 and February 2019 were prospectively included. A significant difference in OS and PFS according to CPI (used highest value of PRGS) was found (OS: CPI−, 83.3, 95% CI [49.8; NA] vs. CPI+, 48.1, 95% CI [38.5; 66.4] months; and PFS (respectively, 59.7, 95% CI [43.0; 96.0] vs. 33.7, 95% CI [30.4; 44.2] months). PRGS or PC had no independent prognostic impact. CPI+ was an independent predictor of worse prognosis, in OS (HR = 5.24, 95% CI [2.07; 13.26]), and PFS (HR = 4.41, 95% CI [1.40; 13.88]).ConclusionsThe CPI based on highest PRGS and PC was found to be independently associated with a worse prognosis for OS and for PFS in the setting of peritoneal metastasis. These results indicate that it should be of interest to systematically take peritoneal fluid for cytological examination and to implement the CPI in the therapeutic decision‐making process in the context of PIPAC.
Evolution of lithospheric mantle in the north of Nain‐Baft oceanic crust (Neo‐Tethyan ophiolite of Ashin, Central Iran)
Authors: Shirdashtzadeh Nargess , Torabi Ghodrat , Morishita Tomoaki 
Published: February 2020

AbstractThis study is focused on a plagioclase‐bearing spinel lherzolite from Chah Loqeh area in the Neo‐Tethyan Ashin ophiolite. It is exposed along the west of left‐lateral strike‐slip Dorouneh Fault in the northwest of Central‐East Iranian Microcontinent. Mineral chemistry (Mg#olivine < ~ 90, Cr#clinopyroxene < ~ 0.2, Cr#spinel < ~ 0.5, Al2O3orthopyroxene > ~ 2.5 wt%, Al2O3clinopyroxene > ~ 4.5 wt%, Al2O3spinel > ~ 41.5 wt%, Na2Oclinopyroxene > ~ 0.11 wt%, and TiO2clinopyroxene > ~ 0.04 wt%) confirms Ashin lherzolite was originally a mid‐oceanic ridge peridotite with low degrees of partial melting at spinel‐peridotite facies in a lithospheric mantle level. However, some Ashin lherzolites record mantle upwelling and tectonic exhumation at plagioclase‐peridotite facies during oceanic extension and diapiric motion of mantle along Nain‐Baft suture zone. This mantle upwelling is evidenced by some modifications in the modal composition (i.e. subsolidus recrystallization of plagioclase and olivine between pyroxene and spinel) and mineral chemistry (e.g. increase in TiO2 and Na2O of clinopyroxene, and TiO2 and Cr# of spinel and decrease in Mg# of olivine), as a consequence of decompression during a progressive upwelling of mantle. Previous geochronological and geochemical data and increasing the depth of subsolidus plagioclase formation at plagioclase‐peridotite facies from Nain ophiolite (~ 16 km) to Ashin ophiolite (~ 35 km) suggest a south to north closure for the Nain‐Baft oceanic crust in the northwest of Central‐East Iranian Microcontinent.
Presence of human papillomavirus DNA in voriconazole‐associated cutaneous squamous cell carcinoma
Authors: Nguyen Cuong V. , He Qin , Rady Peter L. , Tyring Stephen K. , Miller Daniel D. , Rubin Nathan , Kovarik Carrie L. 
Published: February 2020

AbstractBackgroundVoriconazole and genus beta human papillomavirus (HPV) are independently associated with the development of photo‐exposed cutaneous squamous cell carcinoma (SCC) but have not been evaluated concurrently. The objective of this study is to determine the prevalence and type of detectable HPV DNA in voriconazole‐associated SCC.MethodsSCCs from immunosuppressed patients, in those with and without voriconazole exposure, were evaluated by PCR analysis for HPV DNA and compared to SCC from non‐immunosuppressed patients. An additional expanded PCR analysis of all SCC that developed in the voriconazole group was also performed.ResultsHPV DNA was detected by PCR in all groups regardless of the immunosuppression status (80.5%) with beta HPV most prevalent (64.3–78.6%). However, immunosuppressed patients were significantly more likely to be infected by beta HPV types 5, 8, 14, 20, and 21 (P‐value 0.014), and represented the majority of beta HPV types found in the voriconazole group.ConclusionsIn this retrospective study, beta HPV 5, 8, 14, 20, and 21 were commonly detected in voriconazole‐associated SCC. The results indicate a possible role of beta HPV in the pathogenesis of cutaneous SCC in photo‐exposed areas. Further studies are needed to establish the role of HPV and voriconazole in the pathogenesis of the lesion.
Change in irrigation flow through a flexible ureteroscope with various devices in the working channel: Comparison between an automatic irrigation pump and gravity‐based irrigation
Authors: Inoue Takaaki , Yamamichi Fukashi , Okada Shinsuke , Hamamoto Shuzo , Fujisawa Masato ,   the SMART Study Group
Published: February 2020

ObjectivesTo evaluate the change in the irrigation flow with various instruments in the working channel of a flexible ureteroscope by two automatic irrigation pumps and gravity‐based irrigation in an ex vivo setting.MethodsWe used two automatic irrigation pumps: the Endoflow II and the UROMAT Endoscopic Automatic System for Irrigation and gravity‐based irrigation. A flexible ureteroscope was connected to an irrigation tube with a working channel. The other side of the irrigation tube was attached to each automatic irrigation pump, which was connected with a 2‐L saline bag or to a 2‐L saline bag directly in case of gravity pressure. The flow volume from the working channel was measured three times for 30 s at various irrigation pressure settings, both when the working channel was unoccupied and occupied with various instruments.ResultsThe irrigation flow steadily increased as the irrigation pressure in the automatic irrigation pumps increased and the saline position in gravity became higher (P < 0.05). However, the flow decreased as the size of the instrument in the working channel increased (P < 0.05). The efficiency of irrigation flow in gravity‐based irrigation under the same pressure is significantly lower than one of two automatic irrigation pumps (P < 0.05). However, there was no significant difference in the efficiency of the irrigation flow between the Endoflow II and UROMAT Endoscopic Automatic System for Irrigation. The irrigation pressure setting needed to change to maintain adequate irrigation flow when using various working tools.ConclusionsThe efficiency of irrigation flow in gravity‐based irrigation is significantly lower than one of two automatic irrigation pumps. The irrigation flow decreases as the size of the instrument in the working channel increases.
Quality of life of families of adolescents undergoing fixed orthodontic appliance therapy: Evaluation of a cohort of parents/guardians of treated and untreated individuals
Authors: Abreu Lucas Guimarães , Corradi‐Dias Larissa , dos Santos Thiago Rezende , Melgaço Camilo Aquino , Lages Elizabeth Maria Bastos , Paiva Saul Martins 
Published: February 2020

AbstractBackgroundQuality of life (QoL) measurements have been employed in medicine and dentistry to assess the effect of diseases and treatment on individuals’ lives.AimTo assess the effect of the initial 12 months of fixed orthodontic appliance therapy on the families of Brazilian adolescents.DesignA cohort of 11‐ to 12‐year‐old adolescents and their parents/guardians participated. Treatment group (TG) consisted of 101 parents/guardians of adolescents who began fixed orthodontic appliance therapy. They completed four sets of the Family Impact Scale (FIS) at baseline, 1 month, 6 months and 12 months after the bonding of fixed appliances. Control group (CG) was composed of 175 parents/guardians of adolescents, who did not begin treatment, answering four sets of the FIS at the same intervals. The subscales of FIS were parental/family activity (PA), parental emotions (PE), family conflict (FC) and financial burden (FB). Statistical analysis was performed.ResultsThe interaction of group (treatment) with time allowed one to observe significant changes in the PA (P < .001), PE (P < .001), FC (P < .001) and overall FIS score (P < .001), demonstrating an improvement in the subscale and overall QoL of families of adolescents.ConclusionsThe effect of fixed orthodontic appliance therapy on the families of adolescents was highly beneficial.
Vitamin D receptor FokI and BglI genetic polymorphisms, dental caries, and gingivitis
Authors: Barbosa Mariane C. F. , Lima Daniela C. , Reis Caio L. B. , Reis Ana L. M. , Rigo Darlan , Segato Raquel A. B. , Storrer Carmen L. M. , Küchler Erika C. , de Oliveira Daniela S. B. 
Published: February 2020

AbstractBackground & AimTo investigate the association between the genetic polymorphisms FokI (rs2228570) and BglI (rs739837) in vitamin D receptor (VDR) with dental caries and gingivitis susceptibility.DesignThis study included 353 Brazilian children (8 to 11 years old). Dental caries was assessed using ICDAS (International System for Detection and Assessment of Carious Lesions) and gingival bleeding using Community Periodontal Index (CPI). The presence of visible biofilm was also evaluated. DNA was extracted from saliva, and real‐time PCR was used to evaluate genetic polymorphisms in VDR: rs2228570 (FokI, A>G/Met>Thr) and rs739837 (BglI, G>T). Dental caries was evaluated as a continuous data (mean and standard deviation‐SD) and was also categorized (ICDAS0 versus ICDAS1‐6 or ICDAS1‐2 versus ICDAS3‐6). Gingivitis was categorized in with and without. One‐way ANOVA was used for comparisons of caries among genotypes. Chi‐square test, logistic regression, and haplotype analysis were performed (P < .05).ResultsBiofilm was associated with dental caries susceptibility and gingivitis (P < .05). The mean distribution of the caries lesions and cavitated caries lesions among FokI and BgII genotypes were not statistically significant (P > .05). Genotype distributions among caries groups (in the two different cut‐offs) and among gingivitis and non‐gingivitis groups were not statistically significant (P > .05).ConclusionThe polymorphisms FokI and BglI in VDR were not associated with dental caries or gingivitis.
A re‐examination of accruals quality following restatements
Authors: Herly Marie , Bartholdy Jan , Thinggaard Frank 
Published: February 2020

AbstractEmpirical research from the first years following the Sarbanes‐Oxley Act (SOX) in the US suggests that firms improve accruals quality following restatements, but the materiality of restatements has declined since then. This decline may affect firms' responses to restatements, and hence we re‐examine whether restatements are associated with subsequent improvements in accruals quality in a more recent sample. We compare the changes in accruals quality of firms restating between 2000 and 2014 with that of a control group. We do not find that firms improve accruals quality more than the control group following a restatement, even when we isolate the types of restatements considered to be most material. However, we do find that restatements followed by the most negative stock market reactions are associated with a relative increase in accruals quality, indicating that only restatements deemed very severe by investors lead to subsequent improvements in accruals quality. Our results suggest that firms' responses to restatements have changed concurrently with the trend of fewer and less material restatements in recent years.
Intravenous administration of iPS‐MSCSPIONs mobilized into CKD parenchyma and effectively preserved residual renal function in CKD rat
Authors: Sheu Jiunn‐Jye , Sung Pei‐Hsun , Wallace Christopher Glenn , Yang Chih‐Chao , Chen Kuan‐Hung , Shao Pei‐Lin , Chu Yi‐Ching , Huang Chi‐Ruei , Chen Yi‐Ling , Ko Sheung‐Fat , Lee Mel S. , Yip Hon‐Kan 
Published: February 2020

AbstractThis study traced intravenously administered induced pluripotent stem cell (iPSC)‐derived mesenchymal stem cells (MSC) and assessed the impact of iPSC‐MSC on preserving renal function in SD rat after 5/6 nephrectomy. The results of in vitro study showed that FeraTrack™Direct contrast particles (ie intracellular magnetic labelling) in the iPSC‐MSC (ie iPS‐MSCSPIONs) were clearly identified by Prussian blue stain. Adult‐male SD rats (n = 40) were categorized into group 1 (SC), group 2 [SC + iPS‐MSCSPIONs (1.0 × 106cells)/intravenous administration post‐day‐14 CKD procedure], group 3 (CKD), group 4 [CKD + iPS‐MSCSPIONs (0.5 × 106cells)] and group 5 [CKD + iPS‐MSCSPIONs (1.0 × 106cells)]. By day‐15 after CKD induction, abdominal MRI demonstrated that iPS‐MSCSPIONs were only in the CKD parenchyma of groups 4 and 5. By day 60, the creatinine level/ratio of urine protein to urine creatinine/kidney injury score (by haematoxylin and eosin stain)/fibrotic area (Masson's trichrome stain)/IF microscopic finding of kidney injury molecule‐1 expression was lowest in groups 1 and 2, highest in group 3, and significantly higher in group 4 than in group 5, whereas IF microscopic findings of podocyte components (ZO‐1/synaptopodin) and protein levels of anti‐apoptosis ((Bad/Bcl‐xL/Bcl‐2) exhibited an opposite pattern to creatinine level among the five groups (all P < .0001). The protein expressions of cell‐proliferation signals (PI3K/p‐Akt/m‐TOR, p‐ERK1/2, FOXO1/GSK3β/p90RSK), apoptotic/DNA‐damage (Bax/caspases8‐10/cytosolic‐mitochondria) and inflammatory (TNF‐α/TNFR1/TRAF2/NF‐κB) biomarkers displayed an identical pattern to creatinine level among the five groups (all P < .0001). The iPS‐MSCSPIONs that were identified only in CKD parenchyma effectively protected the kidney against CKD injury.
Efficacy of alternative or additional methods to professional mechanical plaque removal during supportive periodontal therapy: A systematic review and meta‐analysis
Authors: Trombelli Leonardo , Farina Roberto , Pollard Alexander , Claydon Nicholas , Franceschetti Giovanni , Khan Iftekhar , West Nicola 
Published: February 2020

AbstractAimsTo systematically review the literature addressing the following focused questions: “What is the efficacy of either (#1) alternative or (#2) additional methods to professional mechanical plaque removal (PMPR) on progression of attachment loss during supportive periodontal therapy (SPT) in periodontitis patients?”.MethodsA systematic search for randomized clinical trials was performed. Change in clinical attachment level (CAL) from baseline was the primary outcome.ResultsRoutine PMPR performed with either a combination of ultrasonic/hand instruments or Er:Yag laser showed similarly effective in preventing CAL loss. Moreover, a routine SPT regimen based on PMPR led to stability of CAL irrespective of a daily sub‐antimicrobial doxycycline dose (SDD). Finally, an adjunctive photodynamic therapy (PDT) did not enhance the magnitude of CAL gain when sites with probing depth ≥4 mm were repeatedly treated. After pooling all data, the results of the meta‐analysis showed no statistical differences in CAL change from baseline: mean overall CAL change was −0.233 mm (95% confidence interval: −1.065, 0.598; p = .351).ConclusionsWeak evidence indicate that in treated periodontitis patients enrolled in a 3–4 month SPT based on PMPR, Er:Yag laser (as alternative), SDD and PDT (as additional) do not produce a greater clinical effect on periodontal conditions compared to PMPR.
A telephone reminder to enhance adherence to interventions in cardiovascular randomized trials: A protocol for a study within a trial (SWAT)
Authors: Bensaaud Abdelsalam , Gibson Irene , Jones Jennifer , Flaherty Gerard , Sultan Sherif , Tawfick Wael , Jordan Fionnuala 
Published: February 2020

AbstractThe impact of reduced adherence in randomized clinical trials is well documented in the literature. Nonadherence can negatively affect the trial sample size and estimation of the treatment effect. This protocol aims to evaluate the effects of a telephone call reminder on the adherence rates of participants to interventions in a cardiovascular randomized trial. This is a study within a trial (SWAT). The host trial is evaluating the effectiveness of a multidisciplinary 16‐wk cardiovascular disease prevention program on risk factor profile among patients with carotid artery stenosis. Simultaneously, this SWAT will evaluate the effectiveness of telephone call reminders on the participants’ adherence to the host trial intervention. The primary outcome is adherence to the protocol of the host trial. Secondary outcomes are level of adherence, number of dropouts, and time to drop out from the host trial.
Understanding the gastrointestinal physiology and responses to feeding in air‐breathing Anabantiform fishes
Authors: Goodrich Harriet R. , Bayley Mark , Birgersson Lina , Davison William G. , Johannsson Ora E. , Kim Anne B. , Le My Phuong , Tinh Tran H. , Thanh Phuong N. , Thanh Huong Do Thi , Wood Chris M. 
Published: February 2020

AbstractThe Mekong Delta is host to a large number of freshwater species, including a unique group of facultative air‐breathing Anabantiforms. Of these, the striped snakehead (Channa striata), the climbing perch (Anabas testudineus), the giant gourami (Osphronemus goramy) and the snakeskin gourami (Trichogaster pectoralis) are major contributors to aquaculture production in Vietnam. The gastrointestinal responses to feeding in these four species are detailed here. Relative intestinal length was lowest in the snakehead, indicating carnivory, and 5.5‐fold greater in the snakeskin, indicating herbivory; climbing perch and giant gourami were intermediate, indicating omnivory. N‐waste excretion (ammonia‐N + urea‐N) was greatest in the carnivorous snakehead and least in the herbivorous snakeskin, whereas the opposite trend was observed for net K+ excretion. Similarly, the more carnivorous species had a greater stomach acidity than the more herbivorous species. Measurements of acid–base flux to water indicated that the greatest postprandial alkaline tide occurred in the snakehead and a potential acidic tide in the snakeskin. Additional findings of interest were high levels of both PCO2 (up to 40 mmHg) and HCO3− (up to 33 mM) in the intestinal chyme of all four of these air‐breathing species. Using in vitro gut sac preparations of the climbing perch, it was shown that the intestinal net absorption of fluid, Na+ and HCO3− was upregulated by feeding but not net Cl− uptake, glucose uptake or K+ secretion. Upregulated net absorption of HCO3− suggests that the high chyme (HCO3−) does not result from secretion by the intestinal epithelium. The possibility of ventilatory control of PCO2 to regulate postprandial acid–base balance in these air‐breathing fish is discussed.
Dispersion and settlement of two sympatric sculpins of the genus Gymnocanthus
Authors: Yamazaki Aya , Ogino Akino , Munehara Hiroyuki 
Published: February 2020

AbstractLarval dispersion rather than adult migration generally leads to the worldwide expansion of fishes. Species of the genus Gymnocanthus have expanded geographically while undergoing allopatric speciation. Of this genus, while Gymnocanthus tricuspis inhabits the Arctic Ocean and surrounding area, G. herzensteini and G. intermedius occur around northern Japan. Larval early life histories of G. herzensteini and G. intermedius from northern Japan and G. tricuspis from Unalaska Island were investigated to estimate their dispersal potential during larval stages. The larval and juvenile abundances of G. herzensteini and G. intermedius were highest in May in shallow sandy bottoms below 7 m in depth, and the body sizes were 9.7–34.6 mm notochord length (NL) and/or standard length (SL) in G. herzensteini and 8.4–46.7 mm NL and/or SL in G. intermedius. Two egg masses of G. tricuspis (1.92 ± 0.08 mm in diameter) and hatched larvae (6.20 ± 0.19 mm NL) were collected in March. Compared with other sculpins in previous studies, the body sizes of G. herzensteini and G. intermedius at hatch are large and at settlement are small, while both hatch and settlement sizes of G. tricuspis are much larger. Counting micro‐increments between the hatch check and settlement marks in G. herzensteini and G. intermedius demonstrated that the pelagic larval durations for 2 weeks with an immature body suggests that these species cannot disperse widely during the pelagic phase, while pelagic larvae of Arctic species such as G. tricuspis with long pelagic larval durations could disperse.
A field evaluation of long‐term effects of PIT tagging
Authors: Skov Christian , Hansen Joan H. , Baktoft Henrik , Brönmark Christer , Brodersen Jakob , Chapman Ben B. , Hansson Lars‐Anders , Hulthén Kaj , Nilsson P. Anders 
Published: February 2020

AbstractPassive integrated transponder (PIT)‐tagging is commonly used in behavioural studies of fish, although long‐term evaluations of effects from tagging under natural conditions are scarce. We PIT‐tagged common bream Abramis brama, European perch Perca fluviatilis, pike Esox lucius and roach Rutilus rutilus, released them in their lakes of origin and recaptured them after 103–3269 days. Overall, tagged fish did not differ in condition from non‐tagged fish, except for small R. rutilus that had a lower length‐specific body mass in one lake in 1 year. We conclude that PIT‐tagging in general has negligible long‐term effects on fish condition.