bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salsolinol—neurotoxic or Neuroprotective?
Authors: Kurnik-Łucka Magdalena , Latacz Gniewomir , Martyniak Adrian , Bugajski Andrzej , Kieć-Kononowicz Katarzyna , Gil Krzysztof 
Published: November 2019

AbstractSalsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was to revisit its potentially neurotoxic and/or neuroprotective role through a series of both in vitro and in vivo experiments. Salsolinol in the concentration range 10–250 μM did not show any significant release of lactate dehydrogenase from necrotic SH-SY5Y cells and was able in the concentration of 50 and 100 μM to rescue SH-SY5Y cells from death induced by H2O2. Its neuroprotective effect against neurotoxin 6-hydroxydopamine was also determined. Salsolinol was found to decrease significantly the reactive oxygen species level in SH-SY5Y cells treated by 500 μM H2O2and the caspase activity induced by 300 μM of H2O2or 100 μM of 6-hydroxydopamine. Serum levels of TNFα and CRP of salsolinol-treated rats were not significantly different from control animals. Both TNFα and CRP served as indirect markers of neurotoxicity and/or neuroprotection. Although the neurotoxic properties of salsolinol have numerously been emphasized, its neuroprotective properties should not be neglected and need greater consideration.
Risk assessment due to intake of trace metals through the ingestion of groundwater around proposed uranium mining areas of Nalgonda district, Telangana, India
Authors: Raghavendra T. , Ramakrishna S. U. B. , Srinivasulu D. , Vijayalakshmi T. , Himabindu V. , Arunachalam J. 
Published: November 2019

AbstractIn the context of proposed uranium mining area, it is very important to evaluate the presence of certain trace metals in groundwater around a proposed uranium mining area at Peddagattu and Seripally areas of Nalgonda district, Telangana (India). The concentrations of certain metals (Cu, Zn, Ni, Pb, Fe, Mn, Cd, Co, Sr, Ba, Cr, Cs and As) were measured in 37 groundwater locations and 10 surface water locations for seven times during 2 years around proposed uranium mining areas. The risk of the chemical toxicant [may be characterized using a hazard quotient (HQ)] is calculated by the results obtained during the study. The HQs of both groundwater (37) and surface water (10) all the considered trace metals were well below the threshold value of 1 as suggested by USEPA.
Fluorescent X-ray Scan Image Quality Prediction
Authors: Weichman Peter B. , Lavely Eugene M. 
Published: November 2019

AbstractThis paper summarizes approaches to image quality prediction in support of an effort under the IARPA RAVEN program to demonstrate a non-destructive, tabletop X-ray microscope for high-resolution 3D imaging of integrated circuits (ICs). The fluorescent X-rays are generated by scanning an electron beam along an appropriately patterned target layer placed in front of the sample and are then detected after passing through the sample by a high-resolution (in both solid angle and energy) backside sensor array. The images are created by way of a model-based tomographic inversion algorithm, with image resolution depending critically on the electron beam scan density and diversity of sample orientations. We derive image quality metrics that quantify the image point spread function and noise sensitivity for any proposed experiment design. Application of these metrics will guide final system design when physical data are not yet available.
The Relationship and Psychosocial Impact of Arousal Incontinence After Radical Prostatectomy
Authors: Salter Carolyn A. , Bach Phil Vu , Katz Darren , Schofield Elizabeth , Nelson Christian J. , Mulhall John P. 
Published: November 2019

Abstract

Introduction
Arousal incontinence (AI) is a lesser known complication of radical prostatectomy (RP), and few data are available on its impact on self-esteem and sexual relationships.

Aim
The goal of this study was to assess the impact of AI on patient self-esteem, confidence, and sexual relationships.

Methods
This was a retrospective study. The validated Self-Esteem and Relationship (SEAR) questionnaire, as well as questions regarding AI, stress urinary incontinence (SUI), climacturia, International Prostate Symptom Score, and the International Index of Erectile Function erectile function domain, were sent to men who had undergone an RP within the past 24 months at a single institution. The data were de-identified and analyzed using descriptive statistics.

Outcomes
The outcomes of this study include prevalence of AI, SEAR domain scores, patient and partner bother, management strategies employed by the patients, and the presence of concurrent climacturia or SUI.

Results
Fifty-three percent of men experienced post-operative AI; of these, 41% were currently experiencing AI, and 12% reported having prior AI that had resolved. Bother of any severity was reported by 87% of men, and perceived partner bother was reported by 64% of men. Forty-one percent of men with current AI avoided sexual activity due to the presence of AI, and 14% of men with prior AI still avoided intercourse. There was no difference in total SEAR score or in the subdomains of self-esteem, sexual relationship, or confidence between men with current AI compared to those with no AI.

Clinical Implications
AI leads to patient bother and avoidance of sexual situations.

Strengths & Limitations
This is the largest study specifically evaluating AI and the only study assessing its impact on self-esteem, sexual relationships, and self-confidence. Limitations include lack of a validated AI questionnaire, poor survey response rate, being a single-center study, and the potential for recall bias.

Conclusion
Although AI is a common occurrence post-RP and is associated with patient bother in the majority of men, it does not impact overall self-esteem, confidence, or sexual relationships compared to post-RP men who have not experienced AI.
Erectile Function and Sexual Satisfaction: The Importance of Asking About Sexual Desire
Authors: Bravi Carlo Andrea , Tin Amy , Montorsi Francesco , Mulhall John P. , Eastham James A. , Vickers Andrew J. 
Published: November 2019

AbstractIntroductionErectile function, libido, and sexual bother are incompletely correlated: a man may or may not be satisfied for a given level of erectile function; similarly, 2 men may have the same erectile function and different levels of sexual desire.AimTo explore the relationship between erectile function, sexual satisfaction and sexual desire.MethodsWe examined the Spearman correlation among erectile function (International Index of Erectile Function [IIEF-6]), sexual desire, and sexual bother in 3,944 questionnaires completed by patients after radical prostatectomy as part of routine care. IIEF-6 scores were adjusted if a patient indicated that the reason for not having intercourse was other than lack of ability of confidence (eg, lack of partner).Main Outcome MeasurePatient-reported outcome instruments.ResultsMedian age at surgery and preoperative IIEF-6 were 63 years and 26, respectively. Among questionnaires completed after surgery, there was moderate correlation among the IIEF-6 score and both sexual desire (Spearman rho: 0.41) and sexual bother (Spearman rho: 0.30). In men who reported high or moderate bother relating to sexual function, there was a narrow distribution of erectile function scores, with most men reporting poor function (median IIEF-6: 6, interquartile range 3, 11). For men who reported small or no problem with sexual function, the distribution of erectile function scores was wide, and particularly bimodal as a function of sexual desire. Among patients with high desire, the correlation between sexual bother and erectile function was 0.61 (ie, the poorer is your function, the greater you are bothered), whereas it was -0.081 among patients with low desire, meaning that some men are not bothered by poor erections.Clinical ImplicationsWe provided useful insights to help physicians during sexual counselling after surgery for prostate cancer.Strength & LimitationsThe study included a large number of patients and provides evidence for implementation of patient-reported outcome insturments. Limitations include the retrospective nature of our data.ConclusionSexual desire helps explain the moderate correlation between erectile function and sexual bother. Sexual desire and bother questions should be incorporated in patient-reported outcome instruments for male sexual function.
A Comparison Between Hyaluronic Acid and Polylactic Acid Filler Injections for Temporary Penile Augmentation in Patients with Small Penis Syndrome: A Multicenter, Patient/Evaluator-Blind, Comparative, Randomized Trial
Authors: Yang Dae Yul , Jeong Hyun Cheol , Ahn Sun Tae , Bae Woong Jin , Moon Du Geon , Kim Sae Woong , Lee Won Ki 
Published: November 2019

Abstract

Introduction
There are only a few studies on the clinical utility of filler injections for penile augmentation (PA) in patients with small penis syndrome (SPS), which is a type of anxiety or body dysmorphic disorder, not a true micropenis.

Aim
To compare the clinical outcomes of hyaluronic acid (HA) with polylactic acid (PLA) filler injection for temporary PA in patients with SPS.

Methods
Our prospective, patient/evaluator-blind, comparative, randomized, non-inferiority trial consisted of a single filler injection and a 24-week post-injection period. Seventy-four men with SPS were included between November 2017 and February 2018. Patients were divided into those injected with HA (n = 39) and those injected with PLA filler (n = 35).

Main Outcome Measure
The psychological effects of PA, based on the Beliefs about Penis Size Scale, penile girth, and satisfaction, were assessed at baseline and at 4, 12, and 24 weeks post-injection.

Results
At 24 weeks, the mean penile girth increases were 2.1 ± 1.0 cm (P &lt; .001) in the HA group and 1.6 ± 0.9 cm (P &lt; .001) in the PLA group, with a mean difference of 0.5 ± 0.2 cm between groups (P = .031). In both groups, satisfaction levels significantly increased at 24 weeks, with 1.8 ± 1.7 and 1.6 ± 1.4 mean increases in the visual analog scale for penile appearance satisfaction in the HA and PLA groups, respectively (each P &lt; .001), and 1.0 ± 1.1 and 0.7 ± 1.2 mean increases in the visual analog scale for sexual life satisfaction in the HA and PLA groups, respectively (each P &lt; .001), with no significant differences between groups (P = .950 and P = .287). The mean Beliefs about Penis Size Scale scores significantly decreased at 24 weeks, with 7.8 ± 8.3 and 5.3 ± 7.2 mean decreases in the HA and PLA groups, respectively (each P &lt; .001), and no significant difference between the groups (P = .920). There were no serious adverse events, but filler injection-related adverse events in the HA and the PLA groups were reported in 2 cases (5.13%) and 5 cases (14.29%), respectively (P = .245).

Clinical Implications
Our study provides an overview of clinical course after HA and PLA filler injections for PA and suggests that filler injections can be considered an alternative approach in patients with SPS.

Strengths & Limitations
Our study is the first to assess the psychological symptoms in patients with SPS who received the filler injection for PA; however, the follow-up duration was insufficient to prove the long-term outcomes of fillers.

Conclusion
Without serious adverse events, HA and PLA filler injections for PA significantly resulted in not only an augmentative effect but also improvement of psychological distress, and the clinical utility was comparable between the fillers.
Preferential attachment when stable
Authors: Janson Svante , Sen Subhabrata , Spencer Joel 
Published: November 2019

AbstractWe study an urn process with two urns, initialized with a ball each. Balls are added sequentially, the urn being chosen independently with probability proportional to the $\alpha$th power $(\alpha >1)$ of the existing number of balls. We study the (rare) event that the urn compositions are balanced after the addition of $2n-2$ new balls. We derive precise asymptotics of the probability of this event by embedding the process in continuous time. Quite surprisingly, fine control of this probability may be leveraged to derive a lower-tail large deviation principle (LDP) for $L = \sum_{i=1}^{n} ({S_i^2}/{i^2})$, where $\{S_n \colon n \geq 0\}$ is a simple symmetric random walk started at zero. We provide an alternative proof of the LDP via coupling to Brownian motion, and subsequent derivation of the LDP for a continuous-time analog of L. Finally, we turn our attention back to the urn process conditioned to be balanced, and provide a functional limit law describing the trajectory of the urn process.
On the ergodicity of a class of level-dependent quasi-birth-and-death processes
Authors: Cordeiro James D. , Kharoufeh Jeffrey P. , Oxley Mark E. 
Published: November 2019

AbstractWe examine necessary and sufficient conditions for recurrence and positive recurrence of a class of irreducible, level-dependent quasi-birth-and-death (LDQBD) processes with a block tridiagonal structure that exhibits asymptotic convergence in the rows as the level tends to infinity. These conditions are obtained by exploiting a multi-dimensional Lyapunov drift approach, along with the theory of generalized Markov group inverses. Additionally, we highlight analogies to well-known average drift results for level-independent quasi-birth-and-death (QBD) processes.
Cluster Expansions for GIBBS Point Processes
Authors: Jansen S. 
Published: November 2019

AbstractWe provide a sufficient condition for the uniqueness in distribution of Gibbs point processes with non-negative pairwise interaction, together with convergent expansions of the log-Laplace functional, factorial moment densities and factorial cumulant densities (correlation functions and truncated correlation functions). The criterion is a continuum version of a convergence condition by Fernández and Procacci (2007), the proof is based on the Kirkwood–Salsburg integral equations and is close in spirit to the approach by Bissacot, Fernández, and Procacci (2010). In addition, we provide formulas for cumulants of double stochastic integrals with respect to Poisson random measures (not compensated) in terms of multigraphs and pairs of partitions, explaining how to go from cluster expansions to some diagrammatic expansions (Peccati and Taqqu, 2011). We also discuss relations with generating functions for trees, branching processes, Boolean percolation and the random connection model. The presentation is self-contained and requires no preliminary knowledge of cluster expansions.
Response of snowpack to +2°C global warming in Hokkaido, Japan
Authors: Katsuyama Yuta , Inatsu Masaru , Shirakawa Tatsuo 
Published: November 2019

AbstractThe response of snowpack to a +2°C global warming relative to the present climate was estimated in Hokkaido, Japan, using a physical snowpack model driven by dynamically downscaled (DDS) data, after model evaluation. The evaluation revealed that the snowpack model successfully reproduced the height of snow cover (HS), snow water equivalent (SWE) and snow-covered days (SCDs), but had a moderate bias in the thickness ratios of melt form (MF) and hoar category (HC). The DDS-forced simulation predicted that the seasonal-maximum HS and SWE would decrease by 30–40% in the southwestern and eastern parts of Hokkaido due to a large decrease in snowfall during the accumulation period, and that the HS and SWE in the north would decrease, albeit not significantly due to uncertain atmospheric forcing. The number of SCDs in Hokkaido was predicted to decline by ~30 d. Additionally, ~50% of snowpack thickness during a season would be MF in most areas, whereas HC would be <50% all over Hokkaido.
Personality Traits and Consumption of Wine and Beer
Authors: Gustavsen Geir W. , Rickertsen Kyrre 
Published: November 2019

AbstractLittle attention has been paid to the effects of personality traits on the consumption of wine and beer. We used a survey to investigate the associations between personality traits and the differences in expected consumption frequencies of wine and beer for 3,482 Norwegian respondents. High scores on extraversion and openness to experiences increased the expected frequency of wine consumption, high score on agreeableness reduced the frequency of wine consumption, while scores on conscientiousness and neuroticism had no effects. For beer, there were no significant effects between personality traits and the frequency of consumption. (JEL Classification: D12, Q13).
Technology and protest: the political effects of electronic voting in India
Authors: Desai Zuheir , Lee Alexander 
Published: November 2019

AbstractElectronic voting technology is often proposed as translating voter intent to vote totals better than alternative systems such as paper ballots. We suggest that electronic voting machines (EVMs) can also alter vote choice, and, in particular, the way in which voters register anti-system sentiment. This paper examines the effects of the introduction of EVMs in India, the world's largest democracy, using a difference-in-differences methodology that takes advantage of the technology's gradual introduction. We find that EVMs are associated with dramatic declines in the incidence of invalid votes, and corresponding increases in vote for minor candidates. There is ambiguous evidence for EVMs decreasing turnout, no evidence for increases in rough proxies of voter error or fraud, and no evidence that machines with an auditable paper trail perform differently from other EVMs. The results highlight the interaction between voter technology and voter protest, and the substitutability of different types of protest voting.
The glycation level of milk protein strongly modulates post-prandial lysine availability in humans
Authors: Nyakayiru Jean , van Lieshout Glenn A. A. , Trommelen Jorn , van Kranenburg Janneau , Verdijk Lex B. , Bragt Marjolijn C. E. , van Loon Luc J. C. 
Published: November 2019

AbstractIndustrial heat treatment of milk results in protein glycation. A high protein glycation level has been suggested to compromise the post-prandial rise in plasma amino acid availability following protein ingestion. In the present study, we assessed the impact of glycation level of milk protein on post-prandial plasma amino acid responses in humans. Fifteen healthy, young men (age 26 (SEM 1) years, BMI 24 (SEM 1) kg/m2) participated in this randomised cross-over study and ingested milk protein powder with protein glycation levels of 3, 20 and 50 % blocked lysine. On each trial day, arterialised blood samples were collected at regular intervals during a 6-h post-prandial period to assess plasma amino acid concentrations using ultra-performance liquid chromatography. Plasma essential amino acid (EAA) concentrations increased following milk protein ingestion, with the 20 and 50 % glycated milk proteins showing lower overall EAA responses compared with the 3 % glycated milk protein (161 (SEM 7) and 142 (SEM 7) v. 178 (SEM 9) mmol/l × 6 h, respectively; P ≤ 0·011). The lower post-prandial plasma amino acid responses were fully attributed to an attenuated post-prandial rise in circulating plasma lysine concentrations. Plasma lysine responses (incremental AUC) following ingestion of the 20 and 50 % glycated milk proteins were 35 (SEM 4) and 92 (SEM 2) % lower compared with the 3 % glycated milk protein (21·3 (SEM 1·4) and 2·8 (SEM 0·7) v. 33·3 (SEM 1·7) mmol/l × 6 h, respectively; P < 0·001). Milk protein glycation lowers post-prandial plasma lysine availability in humans. The lower post-prandial availability of lysine following ingestion of proteins with a high glycation level may compromise the anabolic properties of a protein source.
Assessing the global conservation status of the rock rose Helianthemum caput-felis
Authors: Sulis Elena , Bacchetta Gianluigi , Cogoni Donatella , Gargano Domenico , Fenu Giuseppe 
Published: November 2019

AbstractThe assessment of the conservation status of a species is the first step in developing a conservation strategy. IUCN Red Lists assessments are an important starting point for conservation actions and the most commonly applied method for assessing the extinction risk of a species. In this study, the global conservation status of the rock rose Helianthemum caput-felis Boiss. (Cistaceae), a perennial Mediterranean plant, was evaluated using the Red List criteria. The distribution of the species was determined by monitoring historical localities and all other suitable sites along the western Mediterranean coasts for 6 years. For each confirmed locality, the ecological and population parameters and the main threats were recorded; these data were used in a quantitative analysis of the species' extinction risk. Our findings indicate there have been several recent extinctions, and there is a continuing decline in the species' area of occurrence, habitat quality and number of reproductive plants. The main threats are related to human activities. Extinction models indicate a probability of quasi-extinction risk of c. 30% in five generations or c. 45% in three generations, with the species likely to become extinct in seven currently known localities within the next 10 years. Application of the Red List criteria indicates H. caput-felis should be categorized as Endangered. This study confirms that legal protection and passive conservation measures are insufficient to guarantee the persistence of a plant species. Active conservation and management actions are needed to protect this and other threatened species of the Mediterranean Basin.
High prevalence of Schistosoma haematobium × Schistosoma bovis hybrids in schoolchildren in Côte d'Ivoire
Authors: Angora Etienne K. , Allienne Jean-François , Rey Olivier , Menan Hervé , Touré André O. , Coulibaly Jean T. , Raso Giovanna , Yavo William , N'Goran Eliézer K. , Utzinger Jürg , Balmer Oliver , Boissier Jérôme 
Published: November 2019

AbstractSchistosomiasis is a neglected tropical disease, though it is highly prevalent in many parts of sub-Saharan Africa. While Schistosoma haematobium-bovis hybrids have been reported in West Africa, no data about Schistosoma hybrids in humans are available from Côte d'Ivoire. This study aimed to identify and quantify S. haematobium-bovis hybrids among schoolchildren in four localities of Côte d'Ivoire. Urine samples were collected and examined by filtration to detect Schistosoma eggs. Eggs were hatched and 503 miracidia were individually collected and stored on Whatman® FTA cards for molecular analysis. Individual miracidia were molecularly characterized by analysis of mitochondrial cox1 and nuclear internal transcribed spacer 2 (ITS 2) DNA regions. A mitochondrial cox1-based diagnostic polymerase chain reaction was performed on 459 miracidia, with 239 (52.1%) exhibiting the typical band for S. haematobium and 220 (47.9%) the S. bovis band. The cox1 and ITS 2 amplicons were Sanger sequenced from 40 randomly selected miracidia to confirm species and hybrids status. Among the 33 cox1 sequences analysed, we identified 15 S. haematobium sequences (45.5%) belonging to seven haplotypes and 18 S. bovis sequences (54.5%) belonging to 12 haplotypes. Of 40 ITS 2 sequences analysed, 31 (77.5%) were assigned to pure S. haematobium, four (10.0%) to pure S. bovis and five (12.5%) to S. haematobium-bovis hybrids. Our findings suggest that S. haematobium-bovis hybrids are common in Côte d'Ivoire. Hence, intense prospection of domestic and wild animals is warranted to determine whether zoonotic transmission occurs.