bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which Culture System Is better for Chondrogenesis of Adipose-Derived Stem Cells ; Pellet or Micromass?
Authors: Teimouri Mahtab , Hashemibeni Batool , Mardani Mohammad , Moradi Muhammadhosein 
Published: December 2020

Background and Aims: The current study was conducted to compare the expression levels of collagen type Π and X during chondrogenesis of human adipose-derived mesenchymal stem cells (hADMSCs) pellet and micromass cultures.
Materials and Methods: Extracted hADMSCs were cultured until three passages and then transferred to pellet and micromass cultures in the experimental groups of day 7 and day14. For pellet and micromass cultures, aliquots of 5×105 cells/ml were centrifuged and respectively cultured in the conical tubes and droplets (12.5 µl) of the 24-well plates containing chondrogenic medium. Realtime-polymerase chain reaction technique was performed for gene expression levels.
Results: Increased expression of collagen type Π was shown in micromass day14 compared to micromass day 7, pellet day 14 (p<0.01) and pellet day 7 (p<0.001). Also, an increased expression of collagen type Π was seen in micromass day 7 and pellet day 14 compared to pellet day 7 (p< 0.05). Expression of collagen type X increased in pellet day 14 compared to micromass on days 7 and 14 (p<0.001, p<0.01) and pellet day14 compared to pellet day7 (p< 0.05). An increased expression of collagen type X was shown in pellet day 7 compared to micromass on days 7 and 14 (p<0.05).
Conclusions: According to the results, higher expression of collagen type Π and lower expression of collagen type X in micromass cultures that are prepared by cell suspension play a better role during cellular condensation that leads to the formation of large nodules exhibiting cartilage-like morphology, suggests a higher efficiency for micromass cultures.
Effects of Topical Application of Royal Jelly on Second-Degree Burn Wound Healing in Male Rats
Authors: Mahdian Zeinab , Amiri Fereshteh , Mohammadi Zohreh , Farzadinia Parviz , Safizadeh Fahimeh , Zare Zahra , Rahimi Rahimeh , Dehghani Zahra , Mohammadi Tahroodi Fariba 
Published: December 2020

Background and Aims: Burn injury remain as a major medical problem throughout the world. This injury is accompanied with inflammatory and wound healing responses. Since royal jelly (RJ) has anti-inflammatory and wound healing activity therefore, the aim of this study was to evaluate the repairing effects of RJ on skin burn- damage.
Materials and Methods: In an experimental study, 40 male Wistar rats (8 weeks old) were engaged. The animals were divided into five equal groups. Group 1 was considered healthy control. Group 2 (positive control) was treated topically with Silver Sulfadiazine Cream, group 3 received Eucerin as negative control, and group 4, 5 treated with RJ (10 and 30%). Sampling was performed after observing the second-degree burns on the first, seventh and fourteenth days. Then after 28 days, rats were sacrificed and their skin tissues were used for morphological and morphometric assessments.
Results: The results of this study showed that the amount and arrangement of collagen type 1 protein was higher in the RJ treatment groups versus control group. Reconstruction and thickening of the epithelium in RJ treated groups confirmed therapeutic effects of RJ. In addition, RJ increased angiogenesis compared to the control group. The woundchr('39')s surface area was reduced in the RJ treatment groups compared to the control group. In addition, fibroblast cell proliferation was increased in the groups receiving RJ versus control.
Conclusions: It could be concluded that, RJ induce wound healing effects and might be considered as potential treatment option to improve the burn wound healing.
Fast Response and Overreact: Vietnam’s Success Story in Tackling COVID-19
Authors: Saadah Kholifatus 
Published: December 2020

Pandemi COVID-19 yang mulai menyebar dari awal tahun 2020 sudah menjadi bencana nasional bagi beberapa negara. Virus yang pada awalnya bernama SARS-Cov-2 ini kemudian menyebar dari Wuhan, Cina ke seluruh dunia dan menyebabkan WHO mengumumkan status pandemi. Vietnam merupakan satu dari sekian negara di dunia yang dinyatakan berhasil mengatasi pandemi ini dengan melaporkan nol kasus dalam waktu 14 (empat belas) hari, mengurangi kondisi social-distancing, dan membuka kembali kegiatan masyarakat secara terbuka. Tulisan ini membahas mengenai respon Vietnam pada saat SARS-Cov2 ini mulai mewabah di Vietnam dan strategi dari Pemerintah Vietnam untuk menghentikan wabah di tingkat domestik. Vietnam berhasil menangani COVID-19 karena langkah awal yang, walaupun berlebihan, namun tepat sasaran. Selain itu, peranan identitas nasional Vietnam sebagai negara yang hebat dalam sejarah dan berhasil mengusir siapapun yang menganggu mereka, juga menjadi kunci keberhasilan kolaborasi masyarakat dan pemerintah dalam menghadapi pandemi tersebut. Keberhasilan Vietnam bisa menjadi contoh bagi negara lain yang sedang mencari solusi dan strategi yang tepat untuk menghadapi wabah COVID-19 ini. Kata-kata kunci: SARS-Cov-2, COVID-19, pandemi, Vietnam, strategi The COVID-19 pandemic, which began to spread from early 2020, has become a national disaster for several countries. The virus, initially named SARS-Cov-2, spread from Wuhan, China, to the rest of the world and made WHO declare it as a pandemic status. Vietnam is one of the countries that has been regarded as successful in overcoming this pandemic by reporting zero cases within 14 (fourteen) days, reducing social distancing orders, and re-opening public activities. This paper discussed Vietnam's response when SARS-Cov2 began to plague Vietnam and the government's strategy to control the pandemic at the domestic level. Vietnam succeeded in defeating COVID-19 because of, although excessive, effective initial responses. Also, as a heroic country in history and succeeded in expelling enemies, Vietnam's national identity is the key for successful collaboration between the community and the government in the pandemic counter. Vietnam's success is a model for other countries looking for the right solutions and strategies to deal with the COVID-19 outbreak.Keywords: SARS-Cov-2, COVID-19, pandemic, Vietnam, strategy
The Success of Handling COVID-19 in Singapore: The Case of the Migrant Worker Cluster and the Economic Recession
Authors: Hennida Citra 
Published: December 2020

Artikel ini berfokus pada strategi penanganan COVID-19 di Singapura. Singapura adalah satu negara yang dianggap sukses dalam penanganan COVID-19. Dengan menggunakan analisis kapasitas kebijakan publik dan pegumpulan data selama Januari–Juli 2020, artikel ini menemukan bahwa ada tiga hal yang mendorong keberhasilan Singapura, yaitu: sistem mitigasi bencana kesehatan yang responsif dan efisien; legitimasi pemerintah yang tinggi; dan modal sosial di masyarakat yang pernah mengalami pandemi SARS. Artikel ini juga menemukan bahwa sistem mitigasi bencana kesehatan hanya berlaku maksimal untuk warga lokal, sedangkan warga asing khususnya para pekerja migran kerah biru tidak banyak dijangkau. Klaster asrama pekerja migran adalah klaster terbanyak ditemukan kasus COVID-19 dan lebih dari 90 persen kasus nasional berasal dari kelompok ini. Temuan lainnya adalah jatuhnya Singapura pada resesi dengan pertumbuhan minus 13,2 persen di kuartal kedua tahun 2020. Kebijakan stimulus fiskal dan moneter yang diberikan tidak mampu mendorong pertumbuhan karena ekonomi Singapura yang dependen terhadap ekonomi global; dominasi sektor transportasi, jasa, dan pariwisata Singapura adalah sektor-sektor yang paling terdampak akibat pandemi. Kata-kata kunci: COVID-19, mitigasi bencana kesehatan, pekerja migran, resesi, SingapuraThis article focuses on Singapore's strategies for dealing with COVID-19. Singapore is considered as a successful country in handling COVID-19. Using an analysis of public policy capacity and data collection within January-July 2020, this article finds three driving factors for Singapore's success: a responsive and efficient health disaster mitigation system; a high legitimacy in the government; and society's experience with the SARS epidemic. This article also finds that the health disaster mitigation system only applies optimally to permanent residents. While foreigners, mostly blue-collar migrant workers, are not widely reached. The migrant worker dormitory cluster is a cluster with the highest number of COVID-19 cases detected, which makes up to 90 percent of national cases. Other findings include Singapore's inevitable recession, with a minus 13.2 percent of the economic growth in the second quarter of 2020. The fiscal and monetary stimulus policies provided were not able to boost the economic growth because Singapore's economy depended on the global economy; the dominance of the transportation, service, and tourism sectors Singapore were most affected by the pandemic.Keywords: COVID-19, health disaster mitigation, migrant workers, recession, Singapore
State Capacity and Public Trust in Handling the COVID-19 Outbreak in Malaysia
Authors: Ladiqi Suyatno 
Published: December 2020

Respon negara-negara terhadap pandemi global sangatlah beragam. Kebijakan yang diambil pemerintah dan dukungan dari masyarakat sangat menentukan keberhasilan penanganan pandemi tersebut. Ada beberapa negara yang cukup lama berjuang melawannya sehingga memiliki implikasi ekonomi yang serius. Tetapi, ada juga negara yang secara efisien mengatasinya sehingga mampu menghambat melonjaknya jumlah penderita Covid-19 dan melindungi ekonomi negaranya. Selain Selandia Baru, Taiwan dan China, Malaysia termasuk salah satu negara yang memiliki kapasitas cukup baik dalam penanganan pandemi Covid-19 dalam bentuk kemampuan menekan penyebaran virus, dan menormalkan kembali perekonomiannya. Artikel ini menjelaskan bagaimana kapasitas negara mampu menjadi modal besar dalam penanganan pandemi di Malaysia. Kapasitas negara yang memadai akan mampu menimbulkan kepercayaan publik sehingga kepercayaan itu dapat menjadi katalisator bagi berhasilnya pelaksanaan kebijakan. Selain kapasitas negara, aspek kepemimpinan di level nasional dan level lokal berperan penting dalam mendukung keberhasilan kebijakan pemerintah. Kepemimpinan yang efektif dapat mendorong suasana kondusif bagi ketaatan masyarakat untuk mentaati kebijakan pemerintah. Ibarat musuh bersama (common enemy), dukungan elemen masyarakat sangat diperlukan bagi keberhasilan melawan penyebaran virus.Kata-kata kunci: Malaysia, kapasitas negara, kepercayaan publikCountries' responses to global pandemic have been mixed. The policies taken by the government and the support of the community will significantly determine the success of handling the pandemic. Several countries have struggled against it for a long time to have profound economic implications, but some countries have efficiently dealt with it to prevent the increasing number of Covid-19 sufferers and protect the country's economy. Apart from New Zealand, Taiwan and China, Malaysia is one of the countries that have adequate capacity to handle the Covid-19 pandemic in the form of the ability to suppress the spread of the virus and normalize its economy again. This paper explains how the country's capacity can become a significant capital in handling pandemic in Malaysia. Adequate state capacity will generate public trust so that this trust can be a catalyst for the successful implementation of policies. Apart from the state's capacity, the leadership aspect at the national and local levels plays a vital role in supporting the success of government policies. Effective leadership can encourage a conducive atmosphere for community obedience to comply with government policies. Like a common enemy, the support of social elements is necessary for the success against the spread of the virus.Keywords: Malaysia, state capacity, public trust
PENGARUH VARIASI JUMLAH BAHAN PENGISI CARBON BLACK TERHADAP SIFAT MEKANIK DAN KARAKTERISTIK KARET ALAM PENGINGAT BENTUK
Authors: Setyadewi Noor Maryam , Susiani Endang , Radnawati Efa 
Published: December 2020

Indonesia memiliki potensi komoditi karet alam yang besar, dengan modifikasi kimia karet alam dapat di design menjadi material pintar seperti halnya polimer sintetik lainnya. Material pintar yang dikembangkan pada penelitian ini adalah material shape memory atau pengingat bentuk. Material pengingat bentuk yaitu material yang memiliki kemampuan mengingat bentuk permanen, diprogram untuk menjadi bentuk tertentu dibawah lingkungan tertentu (seperti suhu dan pH), dan mampu kembali ke bentuk awalnya. Material pengingat bentuk berpotensi untuk diaplikasikan menjadi sensor, aktuator, alat kesehatan maupun spare part alat transportasi. Karet alam pengingat bentuk dibuat dengan metode swelling cross linked vulkanisat karet alam di dalam larutan asam stearat dengan suhu 75⁰C - 80⁰C dalam waterbath selama 1 jam. Tujuan dari penelitian ini adalah untuk mempelajari pengaruh variasi jumlah bahan pengisi (carbon black filler) pada 5 sampel (C1, C2, C3, C4, C5) terhadap sifat mekanik dan parameter pengingat bentuk. Hasil pengujian kuat tarik menunjukkan vulkanisat blanko memiliki kecenderungan nilai kuat tarik yang lebih tinggi dibandingkan vulkanisat yang mengalami treatment dengan asam stearat. Nilai shape recovery vulkanisat karet alam pengingat bentuk berkisar 76,9- 95,8% dan nilai shape fixity sebesar 14,8-26,1%.
Immunity of State Owned Non-Commercial Ships and Vessel Protection Detachments in the Foreign Criminal Jurisdiction
Authors: N Nikhilesh 
Published: December 2020

This article studying the issue of sovereign immunity of ships and vessel protection detachments from criminal jurisdiction of foreign courts. The issue immunity of ships from foreign criminal jurisdiction can be understand from Schooner Exchange case onwards. In the initial stages the courts were given absolute immunity of the government ships in the foreign jurisdiction. Later on the courts, jurists and states classified the immunity in two heads such as personal immunity and functional immunity. Immunity not only given to the troika but also to the other officials engaged in the sovereign functions for their respective states with the exception of universal crimes. The status of the warships, government non commercial ships under the law of the sea convention is analysing. At the end the Article considering whether functional immunity applicable to the vessel protection detachments appointed by the states to protect their ship from piracy in accordance with the IMO guidelines.
Developing Database System for Managing Medical Insurance Claims in the Human Resource Department
Authors: Ramadhany Salma Eka , Azwir Hery Hamdi 
Published: December 2020

<p>PT. X Indonesia provides medical insurance for their employee from BPJS Kesehatan and other private company insurance. Currently, the data management of medical insurance members is not efficient and effective because the data regarding medical insurance are managed manually using MS Excel. The manual process leads to incorrect data input and causes a delay in the process of getting treatment and reimbursement claim process. The company will reimburse the payment but the process is long and complicated because the company should check the limitation for reimbursement claim per year. To solve the problem, database systems are constructed using System Development Life Cycle (SDLC) methodology which consists of five phases; systems planning, systems analysis, systems design, systems implementation, and system test, and deployment. The business process flow diagram of the current and proposed system is analyzed. After that, user requirements are determined. The data flow diagram and entity-relationship diagram (ERD) is constructed. And the system is developed using MS Access. Finally, the system is deployed. The result is an application running in MS Access that can manage medical insurance claim with more efficient and effective, compare to previous MS Excel.</p><p> </p>
Early Patellofemoral Articular Cartilage Degeneration in a Rat Model of Patellar Instability is Associated with Activation of the NF-κB Signaling Pathway
Authors: Lin Wei , Kang Huijun , Dai Yike , Niu Yingzhen , Yang Guangmin , Niu Jinghui , Li Ming , Wang Fei 
Published: December 2020

Abstract
Background: Patellar instability (PI) often increases the possibility of lateral patellar dislocation and early osteoarthritis. The molecular mechanism of early articular cartilage degeneration during patellofemoral osteoarthritis (PFOA) still requires further investigation. However, it is known that the NF-κB signaling pathway plays an important role in articular cartilage degeneration. The aim of this study was to investigate the relationship between the NF-κB signaling pathway and patellofemoral joint cartilage degeneration. Methods: We established a rat model of PI-induced PFOA. Female 4-week-old Sprague-Dawley rats (n=120) were randomly divided into two groups: the PI (n=60) and control group (n=60). The distal femurs of the PI and control group were isolated and compared 4, 8, and 12 weeks after surgery. The morphological structure of the trochlear cartilage and subchondral bone were evaluated by micro-computed tomography and histology. The expression of NF-κB, matrix metalloproteinase (MMP)-13, collagen X, and TNF-ɑ were evaluated by immunohistochemistry and quantitative polymerase chain reaction. Results: In the PI group, subchondral bone loss and cartilage degeneration were found 4 weeks after surgery. Compared with the control group, the protein and mRNA expression of NF-κB and TNF-ɑ were significantly increased 4, 8, and 12 weeks after surgery in the PI group. In addition, the markers of cartilage degeneration MMP-13 and collagen X were more highly expressed in the PI group compared with the control group at different time points after surgery.Conclusions: This study has demonstrated that early patellofemoral joint cartilage degeneration can be caused by PI in growing rats, accompanied by significant subchondral bone loss and cartilage degeneration. In addition, the degeneration of articular cartilage may be associated with the activation of the NF-κB signaling pathway and can deteriorate with time as a result of PI.
Parental drinking according to parental composition and adolescent binge drinking: Findings from a nationwide high school survey in Japan
Authors: Inoura Satoshi , Shimane Takuya , Kitagaki Kunihiko , Wada Kiyoshi , Matsumoto Toshihiko 
Published: December 2020

Abstract
Background: Alcohol problems in parents have been revealed to affect adolescent alcohol misuse. However, few studies examine the effects of parental drinking on adolescent risky drinking (including binge drinking) in the general population. In particular, previous study findings are inconsistent regarding the influence of parental drinking according to parental composition. In this study, we aimed to examine the relationship between parental drinking, according to parental composition, and binge drinking among high school students in Japan.Methods: We performed a secondary analysis of the Nationwide High School Survey on Drug Use and Lifestyle 2018, Japan. A total of 46,848 valid surveys from high school students of 78 schools were included for analysis. Logistic regression analysis with a generalized linear mixed model was conducted with binge drinking as the dependent variable and “parental drinking according to parental composition” (e.g., father’s drinking, mother’s drinking, father’s absence, mother’s absence, both parents drinking, and neither parent at home) as the independent variable, after adjusting with covariates. Binge drinking was defined as five or more alcoholic drinks for male adolescents or four or more alcoholic drinks for females on the same occasion within two hours. Results: In the fully adjusted models, adolescents whose mothers drink (adjusted odds ratio (AOR): 1.50, 95% confidence interval (CI): 1.06–2.12) were significantly associated with adolescent binge drinking. This risk was significantly higher among students with neither parent living at home (AOR: 4.35, 95% CI: 2.10–9.02). Conclusion: Parental drinking and absence do affect adolescent binge drinking; our findings show that adolescents are more likely to engage in binge drinking if their mothers drink or if they are not living with either parent. Therefore, it is important to engage parents and non-parental family members in future programs and interventions to prevent adolescent binge drinking.
Stakeholder Perspectives on the Effectiveness of the Victorian Salt Reduction Partnership: A Qualitative Study
Authors: Rosewarne Emalie , Chislett Wai-Kwan , McKenzie Briar , Reimers Jenny , Jolly Kellie-Ann , Corben Kirstan , Trieu Kathy , Webster Jacqui 
Published: December 2020

Abstract
Background: Interventions to reduce population salt intake are feasible and cost-effective. The Victorian Salt Reduction Partnership implemented a complex, multi-faceted salt reduction intervention between 2014 and 2020 in the Australian state of Victoria. This study aimed to understand stakeholder perspectives on the effectiveness of the Victorian Salt Reduction Partnership. Methods: Semi-structured interviews were conducted with Partnership and food industry stakeholders. The Consolidated Framework for Implementation Research was adapted for the Partnership intervention and used to guide the qualitative analysis.Results: Fourteen Partnership and seven food industry stakeholders were interviewed. The Partnership was viewed as essential for intervention planning and decision-making and an enabler for intervention delivery. The goals of capacity building and collaborative action were perceived to have been achieved. The implementation team executed intended intervention activities and outputs, with some adaptations to strategy. Barriers and enablers to implementation were identified by interviewees, such as compatibility of individual, organisational and Partnership values and building positive relationships between the Partnership and food industry, respectively. Legal, political, social, environmental, technological and economic factors affecting intervention design, delivery and outcomes were identified. Conclusions: Establishing a Partnership with diverse skills and experience facilitated collaborative action, capacity building and execution of the intervention. Monitoring and evaluating implementation informed strategy adaptations, which allowed optimisation of Partnership strategy. The importance of developing strong communication networks between strategic and implementation-levels was a key lesson.