bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized, Active-Controlled, 52-Week Study of Hyaluronic Acid Fillers for Anteromedial Malar Region Augmentation
Authors: Huh Chang-Hun , Eom Yunae , Yang So Dam , Shin Jung Won , Seo Kyle Koo-il 
Published: February 2020

Background:
Hyaluronic acid (HA) fillers for volume augmentation in the anteromedial malar region of Asians have been popular for many years. However, studies on their long-term effectiveness are lacking. This study aimed to evaluate the effectiveness and safety of HA fillers injected into the anteromedial malar region for volume augmentation for up to 52 weeks.

Methods:
Each anteromedial malar region of the subjects was treated with YVOIRE Contour (YVOC) in one side and Restylane Sub-Q (RESS) in the other and followed up at weeks 2, 14, 26, and 52. The volume using the mid-face aesthetic scale (MFAS) ranging from 0 (full) to 4 (very severely sunken) and the subject’s satisfaction and adverse events were evaluated.

Results:
Total 83 subjects were randomized and treated with YVOC and RESS. The LS means (standard error) of MFAS score in the YVOC and RESS groups were both 2.56 (0.05) at baseline, 1.32 (0.07) and 1.39 (0.07) at week 26, and 1.84 (0.10) and 1.89 (0.10) at week 52, respectively. The difference in the LS mean of MFAS score between the groups at week 26 was 0.07 (95% confidence interval, 0.01–0.12), showing the non-inferiority of YVOC to RESS. About 70% of subjects were still satisfied with the results at week 52. No specific safety concern was detected.

Conclusions:
The HA fillers injected for the anteromedial malar augmentation maintained the volume well for up to 52 weeks. Additionally, both YVOC and RESS show similar effectiveness and safety profiles.
Modeling Cerebral Hemodynamics Using BOLD Magnetic Resonance Imaging and its Application in Mild Cognitive Impairment
Authors: Henley B.C. , Okafor M.O. , Hajjar I. 
Published: February 2020

AbstractObjectiveThis study develops a procedure and related analytical methods for deriving indices of cerebral hemodynamics in the magnetic resonance imaging (MRI) setting using resting state recordings of systemic blood pressure, pulse rate, and end-tidal CO2 synchronized with the MRI image acquisitions of blood oxygenation level dependent (BOLD) data as a measure of cerebral perfusion.MethodsWe employed the concept of Principal Dynamic Modes (PDM) to model the effect of three determinants of cerebral perfusion: mean arterial blood pressure (MABP), end-tidal CO2 (PETCO2), and pulse rate (PR). The relation between these signals and the BOLD signal were used respectively to quantify cerebral autoregulation (CA), CO2 vasoreactivity (CVR), and pulse rate reactivity (PRR).ResultsHemodynamic indices were obtained from 129 participants with normal cognition (NC) and mild cognitive impairment (MCI). CA was reduced in MCI compared to NC in the parietal lobe, CVR was reduced in MCI in the occipital and temporal lobes, and PRR was reduced in the frontal, parietal, occipital and temporal lobes. Reduced CVR and PRR were associated with worse cognitive scores including memory and executive function.ConclusionEmployed acquisition and analysis of MRI hemodynamic identified cerebral hemodynamic alterations in MCI, related to PR and ETCO2 changes.SignificanceThis modeling approach may offer a novel way to clinically assess cerebral hemodynamics during MRI.
A systematic review and meta-analysis considering the SSRI, SNRI and TCA classes of antidepressants and the risk for congenital heart defects
Authors: De Vries Courtney , Gadzhanova Svetla , Sykes Matthew J. , Ward Michael , Roughead Elizabeth 
Published: February 2020

AbstractBackgroundAntidepressant use during the first trimester is reported in 4% to 8% of pregnancies. The use of some selective serotonin reuptake inhibitors (SSRI) during this stage of gestation has been identified as increasing the odds for congenital heart defects, however little is known about the safety of non-SSRI antidepressants.ObjectiveTo assess the odds of congenital heart defects associated with the use of any antidepressant during the first trimester of pregnancy. To investigate individual classes of antidepressants: SSRIs, serotonin norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants (TCA) and individual antidepressants.Data sourcesPubMed and Embase were searched without restrictions from inception till 2 January 2020.Study selectionProspective and retrospective cohort and case-control studies were included if they documented the maternal usage of antidepressants during the first trimester of pregnancy and assessed the presence of congenital heart defects.Data extraction and meta-analysisData were extracted by two independent reviewers and the endpoint assessed was congenital heart defects. Where studies reported multiple results for different types of heart defects or individual antidepressants, results were combined when possible. Analyses assessing individual antidepressants and classes of antidepressants (SSRIs, SNRIs and TCAs) were undertaken.ResultsA total of 16 studies were identified, encompassing 4,564,798 pregnancy outcomes. The odds ratio for maternal use of any antidepressant and the presence of congenital heart defects from the mixed-methods meta-analysis was 1.22 (95% confidence interval (CI): 1.11 to 1.33).Analyses of antidepressants by class produced an odds ratio of 1.50 (95% CI: 1.19 to 1.89) for maternal SNRI use during the first trimester of pregnancy and the formation of congenital heart defects. A significant odds ratio of 1.22 (95% CI: 1.12 to 1.33) was reported for SSRIs. For the TCA class, no increased odds ratio was found.Analyses of individual antidepressants produced significant odds ratios of 1.53 (95% CI: 1.25 to 1.88), 1.28 (95% CI: 1.01 to 1.62), 1.28 (95% CI: 1.14 to 1.45) and 1.23 (95% CI: 1.01 to 1.50) for paroxetine, fluoxetine, sertraline and bupropion respectively.ConclusionWhile some insight has been gained into which classes of antidepressant and individual antidepressants pose more risk than others for causing congenital heart defects, information regarding some antidepressants is still lacking.
Estimating the causal effect of hearing loss on Alzheimer’s disease: a Mendelian randomisation study
Authors: Jacobs Benjamin M , Noyce Alastair J , Hardy Christopher JD , Warren Jason D , Marshall Charles R 
Published: February 2020

AbstractBackgroundHearing loss has been identified as one of the most important risk factors for Alzheimer’s disease (AD). However, the causality of this association has not been established.MethodsWe used publicly available GWAS summary statistics to construct instrumental variables for age-related hearing difficulty. We tested these genetic instruments for association with the outcome of AD using AD GWAS summary statistics in a two-sample Mendelian randomisation analysis. We used inverse-variance weighted meta-analysis to estimate the causal effect of hearing-related traits on AD, followed by secondary sensitivity analyses including a mixture of experts approach.ResultsThere was no strong evidence for a causal relationship between genetically-determined hearing difficulty (ORFE-IVW 1.27, 95% CI 0.89 to 1.82, p=0.189) and AD risk. There was no evidence to suggest that unbalanced horizontal pleiotropy was biasing the result. Power calculations indicated our instruments were sufficiently powered to detect the magnitude of effect described in case-control and cohort settings.ConclusionsOur results suggest that the size of the observed relationship between hearing loss and AD cannot be completely accounted for by a direct causal influence. Hearing loss may have more utility as a risk marker for AD than as a modifiable risk factor.
Visual Experience is not Necessary for the Development of Face Selectivity in the Lateral Fusiform Gyrus
Authors: Ratan Murty N. Apurva , Teng Santani , Beeler David , Mynick Anna , Oliva Aude , Kanwisher Nancy 
Published: February 2020

AbstractHere we show robust face-selectivity in the lateral fusiform gyrus of congenitally blind participants during haptic exploration of 3D-printed stimuli, indicating that neither visual experience, nor fovea-biased input, nor visual expertise is necessary for face-selectivity to arise in its characteristic location. Similar resting fMRI correlation fingerprints in individual blind and sighted participants suggest a role for long-range connectivity in the specification of the cortical locus of face-selectivity.
Accurate localization of linear probe electrodes across multiple brains
Authors: Liu Liu D , Chen Susu , Economo Michael N , Li Nuo , Svoboda Karel 
Published: February 2020

AbstractRecently developed silicon probes have large numbers of recording electrodes on long linear shanks. Specifically, Neuropixels probes have 960 recording electrodes distributed over 9.6 mm shanks. Because of their length, Neuropixels probe recordings in rodents naturally span multiple brain areas. Typical studies collate recordings across several recording sessions and animals. Neurons recorded in different sessions and animals have to be aligned to each other and to a standardized brain coordinate system. Here we report a workflow for accurate localization of individual electrodes in standardized coordinates and aligned across individual brains. This workflow relies on imaging brains with fluorescent probe tracks and warping 3-dimensional image stacks to standardized brain atlases. Electrophysiological features are then used to anchor particular electrodes along the reconstructed tracks to specific locations in the brain atlas and therefore to specific brain structures. We performed ground-truth experiments, in which motor cortex outputs are labelled with ChR2 and a fluorescence protein. Recording from brain regions targeted by these outputs reveals better than 100 μm accuracy for electrode localization.
Nicotine exposure and neuronal activity regulate Golgi membrane dispersal and distribution
Authors: Govind Anitha P. , Jeyifous Okunola , Russell Theron A. , Vaasjo Lee O. , Yi Zola , Weigel Aubrey V. , Newell Luke , Koranda Jessica L. , Singh Karanveer , Valbuena Fernando , Glick Benjamin S. , Mukherjee Jogeshwar , Lippincott-Schwartz Jennifer , Zhuang Xiaoxi , Green William N. 
Published: February 2020

AbstractHow nicotine exposure produces long-lasting changes that remodel neural circuits with addiction is unknown. Here, we report that long-term nicotine exposure alters the trafficking of α4β2-type nicotinic acetylcholine receptors (α4β2Rs) by dispersing and redistributing the Golgi apparatus. In cultured neurons, dispersed Golgi membranes were distributed throughout somata, dendrites and axons. Small, mobile vesicles in dendrites and axons lacked standard Golgi markers and were identified by other Golgi enzymes that modify glycans. Nicotine exposure increased levels of dispersed Golgi membranes, which required α4β2R expression. Similar nicotine-induced changes occurredin vivoat dopaminergic neurons at mouse nucleus accumbens terminals, consistent with these events contributing to nicotine’s addictive effects. Characterizationin vitrodemonstrated that dispersal was reversible, that dispersed Golgi membranes were functional, and that membranes were heterogenous in size, with smaller vesicles emerging from larger “ministacks”, similar to Golgi dispersal induced by nocadazole. Protocols that increased cultured neuronal synaptic excitability also increased Golgi dispersal, without the requirement of α4β2R expression. Our findings reveal novel activity- and nicotine-dependent changes in neuronal intracellular morphology. These changes regulate levels and location of dispersed Golgi membranes at dendrites and axons, which function in local trafficking at subdomains.
Molecular characterization of unusual G10P[33], G6P[14] genomic constellations and evidence of zooanthroponosis in bovines
Authors: Sawant P.M , Digraskar S , Gopalkrishna V. 
Published: February 2020

AbstractGroup A rotaviruses (RVA) are a major cause of diarrhea in neonatal calves and children. The present study examined G/P combinations and genetic characteristics of RVAs in diarrheic bovine calves in Western India. RVAs were detected in 27 samples (17.64%) with predominance of G10P[11] (51.85%), followed by previously unreported genomic constellations, G6P[14] (14.81%), and, G6P[4] (7.40%) and G10P[33] (3.70%). Sequencing and phylogenetic analysis revealed circulation of G10 (Lineage-5), G6 (Lineage-2), P[11] (Lineage-3), P[14] (proposed Lineage-8) and P[4] (Lineage-3) genotypes. The predominant G10P[11] strains were typical bovine strains and exhibited genotypic homogeneity. The rare, G10P[33] strain, had VP7 and VP4 genes of bovine origin but resemblance of VP6 gene with simian strain indicated possible reassortment between bovine and simian (SA11-like) strains. The VP6 and VP7 genes of other two rare strains, G6P[14] and G6P[4], were similar to those of bovine stains, but the VP4 was closely related to those of the human-bovine like and human strains, respectively. Additionally, in VP4 gene phylogenetic tree Indian P[14] strains constituted a closely related genetic cluster distinct from the other P[14] strains, hence Lineage-8 was proposed for them. These findings indicated that bovines could serve as source for anthropozoonotic transmission of G6P[14] strains while zooanthroponotic transmission followed by reassortment with human strain gave rise to G6P[4] strains. The observations of present study reinforce the potential of rotaviruses to cross the host-species barrier and undergo reassortant to increase genetic diversity which necessitates their continuous surveillance for development and optimization of prevention strategies against zoonotic RVAs.
The infection evidence of SARS-COV-2 in ocular surface: a single-center cross-sectional study
Authors: Zhang Xian , Chen Xuhui , Chen Liwen , Deng Chaohua , Zou Xiaojing , Liu Weiyong , Yu Huimin , Chen Bo , Sun Xufang 
Published: February 2020

PurposeThe aim of this study was to identify whether SARS-COV-2 infected in ocular surface.MethodsCross-sectional study of patients presenting for who received a COVID-19 diagnosis, from December 30, 2019 to February 7, 2020, at Tongji hospital, Tongji medical college, Huazhong University of Science and Technology. Demographics, temperature was recorded, blood routine test (Rt), chest Computed Tomography (CT) were took intermittently, and SARS-COV-2 real-time reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay were arranged for the nasopharyngeal and conjunctival swab samples.ResultsA total of 102 patients (48 Male [50%] and 54 Female [50%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. Patients had a mean [SD] gestational age of 57.63 [14.90] years. Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) confirmed by laboratory diagnosis with SARS-COV-2 RT-PCR assay. Only two patients (2.78%) with conjunctivitis was identified from 72 patients with a laboratory confirmed COVID-19. However, SARS-COV-2 RNA fragments was found in ocular discharges by SARS-COV-2 RT-PCR only in one patient with conjunctivitis.ConclusionsAlthough we suspect the incidence of SARS-COV-2 infection through the ocular surface is extremely low, the nosocomial infection of SARS-CoV-2 through the eyes after occupational exposure is a potential route. The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-COV-2. Therefore, to lower the SARS-COV-2 nosocomial infection, the protective goggles should be wore in all the health care workers.
Heteroplasmy variability in individuals with biparentally inherited mitochondrial DNA
Authors: Slone Jesse , Zou Weiwei , Luo Shiyu , Schmitt Eric S , Chen Stella Maris , Wang Xinjian , Brown Jenice , Bromwell Meghan , Chien Yin-Hsiu , Hwu Wuh-Liang , Fan Pi-Chuan , Lee Ni-Chung , Wong Lee-Jun , Zhang Jinglan , Huang Taosheng 
Published: February 2020

ABSTRACTWith very few exceptions, mitochondrial DNA (mtDNA) in humans is transmitted exclusively from mothers to their offspring, suggesting the presence of a strong evolutionary pressure favoring the exclusion of paternal mtDNA. We have recently shown strong evidence of paternal mtDNA transmission. In these rare situations, males exhibiting biparental mtDNA appear to be limited to transmitting just one of the mtDNA species to their offspring, while females possessing biparental mtDNA populations consistently transmit both populations to their offspring at a very similar heteroplasmy level. The precise biological and genetic factors underlying this unusual transmission event remain unclear. Here, we have examined heteroplasmy levels in various tissues among individuals with biparental inheritance. Our results indicate that individuals with biparental mtDNA have remarkable inter-tissue variability in heteroplasmy level. At the single-cell level, paternal mtDNA heteroplasmy in sperm varies dramatically, and many sperm possess only one of the two mtDNA populations originally in question. These results show a fundamental, parent-of-origin difference in how mtDNA molecules transmit and propagate. This helps explain how a single population of mtDNAs are transmitted from a father possessing two populations of mtDNA molecules, suggesting that some mtDNA populations may be favored over others when transmitted from the father.
Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset
Authors: Xiong Yuguang , Liu Tong , Chen Tong , Hansen Jens , Hu Bin , Chen Yibang , Jayaraman Gomathi , Schürer Stephan , Vidovic Dusica , Goldfarb Joseph , Sobie Eric A. , Birtwistle Marc R. , Iyengar Ravi , Li Hong , Azeloglu Evren U. 
Published: February 2020

AbstractThe Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that can predict adverse effects, especially cardiotoxicity, of kinase inhibitors approved by the Food and Drug Administration. Towards this goal, high throughput shot-gun proteomics experiments (317 cell line/drug combinations + 64 control lysates) have been conducted at the Center for Advanced Proteomics Research at Rutgers University - New Jersey Medical School. Using computational network analyses, these proteomic data can be integrated with transcriptomic signatures generated in tandem to identify cellular signatures of cardiotoxicity that may predict kinase inhibitor-induced toxicity and possible mitigation. Both raw and processed proteomics data have been carefully screened for quality and made publicly available via the PRIDE database. As such, this broad protein kinase inhibitor-stimulated cardiomyocyte proteomic data and signature set is valuable for the prediction of drug toxicities.Links to: Metadata Tables
Synergistic hybrid-electric liquid natural gas drone: S.H.I.E.L.D
Authors: Sibilli Thierry , Senne Capucine , Jouan Hugo , Isikveren Askin T. , Ayat Sabrina 
Published: February 2020

Purpose
With the objective to assess potentially performant hybrid-electric architectures, this paper aims to present an aircraft performance level evaluation, in terms of range and payload, of the synergies between a hybrid-electric energy system configuration and a cryogenic fuel system.

Design/methodology/approach
An unmanned aerial vehicle (UAV) is modeled using an aircraft performance tool, modified to take into account the hybrid nature of the system. The fuel and thermal management systems are modeled looking to maximize the synergistic effects. The electrical system is defined in series with the thermal engine and the performance, in terms of weight and efficiency, are tracked as a function of the cooling temperature.

Findings
The results show up to a 46 per cent increase in range and up to 7 per cent gain on a payload with a reference hybrid-electric aircraft that uses conventional drop-in JP-8 fuel. The configuration that privileges a reduction in mass of the electric motors by taking advantage of the cryogenic coolant temperature shows the highest benefits. A sensitivity study is also presented showing the dependency on the modeling capabilities.

Practical implications
The synergistic combination of a cryogenic fuel and the additional heat sources of a hybrid-electric system with a tendency to higher electric component efficiency or reduced weight results in a considerable performance increase in terms of both range and payload.

Originality/value
The potential synergies between a cryogenic fuel and the electrical system of a hybrid-electric aircraft seem clear; however, at the present, no detailed performance evaluation at aircraft level that includes the fuel, thermal management and electric systems, has been published.
The interaction of situational factors on individual factors and self-development
Authors: Zia Muhammad Qamar , Naveed Muhammad , Bashir Muhammad Adnan , Shamsi Aamir Feroz 
Published: February 2020

PurposeOrganizations are facing pressure to reduce costs of training and enhancing the role of self-development that is self-driven and contextual in nature as a means to supplement employee development. The purpose of this study is to investigate the influence of individual and situational factors on self-development as well as the moderating role of situational factors. Individual factors are referred to personal characteristics, i.e. learning goal orientation and proactive personality, while situational factors are environmental conditions, including job autonomy and empowering environment.Design/methodology/approachData were gathered from 280 middle managers of the banking sector. Partial least squares structural equation modeling was conducted to validate the model.FindingsThe study findings revealed a significant direct relationship of individual (learning goal orientation and proactive personality) and situational (empowering environment and job autonomy) factors with self-development. The study also found only a significant moderating effect of empowering environment in relation to learning goal orientation and self-development, correspondingly job autonomy moderates the relationship of proactive personality and self-development.Practical implicationsThe study concludes with offering some implication for organization to focus on self-development activities by providing an empowering environment and job autonomy to its employees, which will result to minimize the overall cost of training. Organizations should also identify the individual factors that lead to self-development like proactive personality and learning goal orientation.Originality/valueThis study gives new insight on the predictors of self-development and their interaction. This study may be a pioneer to empirically validate a theoretical model about the interaction of situational factors between individual factors and self-development. Furthermore, it contributes and advances our knowledge by demonstrating how individual and situational factors are influencing middle mangers’ self-development in workplace.