bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pertanian Organik: Konsep, Kinerja, Prospek, dan Kendala
Authors: Purwantini Tri Bastuti , Sunarsih NFN 
Published: December 2020

<p>Organic agriculture grows rapidly both at national and global levels triggered by consumers’’ awareness of the dangers of synthetic chemicals in agriculture. Consumers are increasingly wise in choosing healthy, environmentally friendly food. The paper aims to describe the concept of organic agriculture and from international and national views, followed by an explanation of the development of organic agriculture in Indonesia. Discussion on the concept and development of organic agriculture in Indonesia covers the performance of organic agriculture development, programs, area, producers and markets. The results of the study indicate that Indonesia has considerable potential to compete in international markets of organic agriculture products albeit gradually. Institutions such as those of conventional agriculture, i.e. farmers’ groups, cooperatives, associations or corporations, are still very relevant to boost organic agriculture development. Organic agricultural products in the transition period are still pioneering the market. The community is the closest market accessible. Organic farming education should involve producers and consumers.</p><p> </p><p>Abstrak</p><p>Pertanian organik tumbuh pesat di tingkat nasional maupun global. Hal ini seiring peningkatan kesadaran konsumen terhadap bahaya bahan kimia sintetis dalam produk pertanian. Konsumen makin bijak dalam memilih bahan pangan yang aman bagi kesehatan dan ramah lingkungan. Tujuan makalah ini adalah untuk mendeskripsikan konsep pertanian organik menurut pandangan internasional maupun nasional, dilanjutkan dengan pemaparan perkembangan pertanian organik di Indonesia. Pembahasan tentang konsep dan perkembangan pertanian organik di Indonesia mencakup kinerja perkembangan pertanian organik, program, luas areal, produsen, dan pasar produk organik. Hasil kajian menunjukkan bahwa Indonesia memiliki potensi yang cukup besar untuk bersaing di pasar internasional walaupun secara bertahap. Secara kelembagaan pengembangan pertanian organik di Indonesia hampir sama dengan pertanian konvensional, seperti kelompok tani, koperasi, asosiasi, atau korporasi masih sangat relevan untuk digunakan sebagai pengembangan pertanian organik. Produk pertanian organik pada masa transisi masih merintis pasar dan biasanya komunitas menjadi pasar terdekat yang bisa dijangkau. Edukasi tentang pertanian organik perlu dilakukan pada kedua sisi, produsen dan konsumen.</p>
La comunicación como herramienta clave en la docencia de postgrado durante los momentos de crisis
Authors: Cortés Cortés Manuel Enrique 
Published: December 2020

Señor Editor:
Con especial atención leí el interesante artículo de Valcazar Montenegro (2019), publicado recientemente en Desde el Sur. Esta investigación tuvo como objetivo comparar los niveles de evaluación de las competencias del docente desde la percepción de los estudiantes de cuatro programas de maestría especializadas. Como resultado, se encontró que existen diferencias significativas al comparar los niveles de evaluación de las competencias de los docentes desde la perspectiva estudiantil. En dicho estudio, las competencias con mayor valoración fueron: la selección de contenidos disciplinares, el diseñar la metodología y organizar las actividades, ofrecer información y explicaciones comprensibles y comunicarse-relacionarse con los alumnos (Valcazar Montenegro, 2019). Considerando lo anterior, esta Carta al Editor se centra en una de ellas: la comunicación. Por lo tanto, el objetivo de este artículo es destacar la importancia de la comunicación como herramienta clave para la docencia de postgrado.
Introducción al concepto de fractal en enseñanza secundaria usando realidad virtual inmersiva
Authors: Chavil Montenegro Dante Yván , Romero Albadalejo Isabel María , Rodríguez Blancas José Luis 
Published: December 2020

El concepto de fractal no se introduce en secundaria a pesar de su potencial a nivel matemático y de su aplicabilidad. La realidad virtual es una herramienta adecuada que facilita dicha introducción. Nuestro interés radica en conocer la influencia del uso del software de realidad virtual inmersiva NeoTrie VR en el aprendizaje y la motivación de los fractales en estudiantes de primer año de educación secundaria. Se sigue un esquema de investigación de orientación cualitativa y de tipo descriptivo, con tres grupos de estudiantes de cuatro integrantes cada uno. Los resultados muestran que NeoTrie VR facilita la construcción de fractales y observamos que ello incide positivamente en la asimilación de la noción de fractal. Además, los estudiantes manifiestan concentración y disfrute, acorde con la experiencia de flujo, al hacer uso de este software.
Digital Health Interventions for Healthy Aging: A Qualitative User Evaluation and Ethical Assessment
Authors: Ienca Marcello , Schneble Christophe , Kressig Reto , Wangmo Tenzin 
Published: December 2020

Abstract
BackgroundDigital health technologies are being increasingly developed with the aim of allowing older adults to maintain functional independence throughout the old age, a process known as healthy ageing. Such digital health technologies for healthy ageing are expected to mitigate the socio-economic effects of population ageing and improve the quality of life of older people. However, little is known regarding the views and needs of older people regarding these technologies. AimThe aim of this study is to explore the views, needs and perceptions of community-dwelling older adults regarding the use of digital health technologies for healthy ageing. MethodFace-to-face, in-depth qualitative interviews were conducted with community-dwelling older adults (median age 79.6 years). The interview process involved both abstract reflections and practical demonstrations. The interviews were transcribed verbatim and analyzed according to inductive content analysis. ResultsThree main themes and twelve sub-themes emerged. The three main themes revolved around the following thematic areas: favorable views and perceptions on technology-assisted living, usability evaluations and ethical considerations. ConclusionsOur study reveals a generally positive attitude towards digital health technologies as participants believed digital tools could positively contribute to improving their overall wellbeing, especially if designed in a patient-centered manner. Safety concerns and ethical issues related to privacy, empowerment and lack of human contact also emerged as key considerations.
Facilitators and barriers to Pre-Exposure Prophylaxis (PrEP) uptake among adolescent girls and young women in Seme-Sub County, Kisumu, Kenya
Authors: Jackson-Gibson Maya , Ezema Ashley , Orero Wicklife , Were Irene , Ohiomoba Ramael , Mbullo Patrick , Hirschhorn Lisa 
Published: December 2020

Abstract
Background: While the introduction of HIV pre-exposure prophylaxis (PrEP) as an HIV prevention strategy has allowed women to exercise more control over the reduction of HIV transmission rates, adolescent girls and young women (AGYW) in Sub-Saharan Africa continue to experience higher rates of HIV infections and bear the greatest disease burden. Understanding progress in PrEP uptake among AGYW would enhance risk reduction in this vulnerable population. The Determined, Resilient, AIDS-Free, Mentored and Safe women (DREAMS) Initiative plays a key role in this risk reduction strategy.Methods: We performed a retrospective qualitative study to explore facilitators and barriers to PrEP, specifically those effecting initiation and persistence, among AGYW enrolled in the DREAMS Initiative at Pamoja Community Based Organization (CBO) in Kisumu, Kenya. We conducted key informant interviews (n = 15) with Pamoja CBO staff, health care providers and community leaders. Additionally, we conducted focus group discussions with young women receiving PrEP (n = 40) and peer mentors (n = 12). We did thematic analysis using the Consolidated Framework for Implementation Research to identify emergent themes.Results: We found that the use of the safe space model, decentralization of PrEP support and delivery, peer mentors, proper linkage to local health care facilities, and the sensitization of parents and male sexual partners were among some of the facilitators to PrEP uptake. Barriers to initiation and persistence included stigma associated with the use of anti-retroviral dugs, distance to safe spaces, and limited testing and qualified health care workers for PrEP distribution and administration.Conclusions: Overall, community roll out of PrEP within the DREAMS Initiative was successful in part due to integration and layering of services (biological, behavioral and structural), increased self-efficacy among AGYW, enhanced inter-agency and multisectoral collaboration.
Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis
Authors: Sun Yulin , Guo Zhengguang , Jing Zongpan , Li Jun , Yang Lijun , Liu Xiaoyan , Cai Meng , Zheng Zhaoxu , Shao Chen , Zhang Yefan , Sun Haidan , Wang Li , Han Yue , Zou Shuangmei , Gao Jiajia , Sun Yan , Zhao Yan , Nan Peng , Xie Xiufeng , Tian Lusong , Liu Fang , Zhou Lanping , Sun Wei , Zhao Xiaohang 
Published: December 2020

Abstract
Currently, imaging and serum carcinoembryonic antigen (CEA) tests are not sufficient for early detection and evaluation of metastasis and recurrence in colorectal cancer (CRC). To comprehensively discover and validate more accurate noninvasive biomarkers in urine, we adopted a staged discovery-verification-validation pipeline in 657 urine and 665 tissue samples from healthy controls and CRC patients with a distinct metastatic risk. The diagnostic signature generated combined with serum CEA levels revealed a significantly increased sensitivity (+34.8%) compared to CEA alone. Moreover, over 50% of CEA-negative metastatic patients were correctly predicted by the metastatic signature generated for metastatic risk. The tissue validation and functional study showed that CORO1C was associated with distant metastasis and enhanced the invasion and metastasis of CRC cells via a novel integrin/FAK/SRC and relevant pathways. Our findings provide novel urinary protein biomarkers and potential interventional targets to reliably detect CRC, especially in patients with metastatic CRC.
Phosphorylation of LCB1 subunit of serine palmitoyltransferase stimulates its activity and modulates sphingolipid biosynthesis in Arabidopsis
Authors: Li Yuan , Cao Hanwei , Dong Tingting , Wang Xiaoke , Ma Liang , Li Kun , Lou Huqiang , Song Chun-Peng , Ren Dongtao 
Published: December 2020

Abstract
Sphingolipids are the structural elements for membrane lipid bilayers and the signal molecules for many cellular processes. Serine palmitoyltransferase (SPT) is the first committed and rate-limiting enzyme in the de novo sphingolipids biosynthetic pathway. The core SPT was previously suggested as a heterodimer consisting of LCB1 and LCB2 subunits. The SPT activity was shown to be inhibited by orosomucoid proteins (ORMs) and stimulated by small subunits of SPT (ssSPT). However, whether LCB1 is modified and how the modification regulates SPT activity have been unclear. Here, we show that activation of MPK3 and MPK6 by upstream MKK9 and Flg22 (a pathogen-associated molecular pattern) treatment increases SPT activity and induces the accumulation of sphingosine long-chain base (LCB) t18:0 in Arabidopsis thaliana; the activated MPK3 and MPK6 phosphorylate AtLCB1. Phosphorylation of AtLCB1 strengthens its binding with AtLCB2b, promotes its binding with ssSPTs, and stimulates the higher-order-oligomer and active SPT complexes formation. Our findings suggest a novel regulatory mechanism of SPT activity.
Subacromial Erosion after Hook Plate Fixation in Acute Acromioclavicular Joint Dislocation
Authors: Kim Jung Youn , Rhee Yong Girl , Ko Young Wan , Rhee Sung Min 
Published: December 2020

Abstract
Background: This study was to analyze the clinical results of locking hook plate fixation for acute acromioclavicular joint (ACJ) injury and to find out the incidence of subacromial erosion, carry out quantitative analysis and identify risk factors. Methods: The study was conducted on 35 patients who underwent the locking hook plate fixation for acute ACJ joint injury. The clinical outcomes were evaluated measuring the visual analog scale (VAS) for pain, and the University of California at Los Angeles (UCLA) score. The computed tomography (CT) was conducted to measure the subacromial erosion. The acromioclavicular slope (AC slope) of the unaffected side, the acromion-hook angle (AH angle), the acromioclavicular anteroposterior distance (AC-AP distance), and the preoperative acromioclavicular interval (ACI) of the affected side were analyzed to identify the risk factors of subacromial erosion. Results: The mean preoperative VAS score was 7.6 points, which improved by a significant level of 0.3 at the final follow-up (P <0.001). The UCLA score at the last follow-up was 32.3 points, which was higher than the preoperative average of 15.2 points (P = 0.003). According to the computed tomography (CT) findings, subacromial erosion was found in all cases, and the mean value was 5.0mm, which is 53% of the entire acromion thickness. The AC slope (B=-0.159, P<0.001) and AC-AP distance (B=0.233, P=0.004) were found to have a significant influence on postoperative subacromial erosion. The AC slope showed a negative correlation with the amount of erosion, while the AC-AP distance showed a positive correlation with erosion. onclusion: The study was able to obtain satisfactory clinical and radiological results after locking hook plate fixation for acute ACJ injury. The CT findings revealed that subacromial erosion occurred in all cases, and the mean erosion depth was about 50% of the acromial thickness. If the preoperative AC slope of the unaffected side was more acute and the AC-AP distance was larger, the incidence of subacromial erosion was higher. Level of evidence: Therapeutic Level IV Retrospectively registered study: This study was retrospective in nature, and final approval of informed consent exemption by the institutional review board was obtained (KHUH IRB 2019-04-079)
Increased depression genetic liability associates with inflammatory markers in multiple electronic health record systems
Authors: Davis Lea , Sealock Julia , Lee Younga , Moscati Arden , Venkatesh Sanan , Voloudakis Georgios , Straub Peter , Singh Kritika , Feng Yen-Chen , Ge Tian , Roussos Panos , Smoller Jordan W. , Chen Guanhua 
Published: December 2020

Abstract
Although depression is a common disorder, its underlying biological basis remains poorly understood. The results of clinical lab tests available for research in electronic health records can be used to identify biomarkers that may reveal biological processes involved in the development of depression or may be markers of physiological changes due to depression. Here, we leveraged clinical laboratory tests and integrated biobank data to evaluate the relationship between genetic risk for depression and 315 routinely collected quantitative lab measures. Analyses across four health care systems (N = 382,452) robustly implicate increased white blood cell count as both a risk factor and consequence of depression diagnosis and revealed neutrophils, lymphocytes, and monocytes as the primary cell types responsible for this association. Our results highlight the importance of the immune system in the etiology of depression and motivate future development of clinical biomarkers and targeted treatment options for depression and its systemic effects.
Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy
Authors: Thakkar Astha , Pradhan Kith , Jindal Shawn , Cui Zhu , Rockwell Bradley , Shah Akash , Packer Stuart , Sica R.Alejandro , Sparano Joseph , Goldstein D.Yitzhak , Verma Amit , Goel Sanjay , Halmos Balazs 
Published: December 2020

Abstract
Patients with cancer have been identified in several studies to be at high risk of developing severe COVID-19; however, rates of SARS-CoV-2 IgG seroconversion and its association with cancer types and anti-cancer therapy remain obscure. We conducted a retrospective cohort study in patients with cancer that underwent SARS-CoV-2 IgG testing. Two hundred and sixty-one cancer patients underwent SARS-CoV-2 IgG testing and demonstrated a high rate of seroconversion (92%). However, significantly lower seroconversion was observed in patients with hematologic malignancies (82%), patients that received anti-CD-20 antibody therapy (59%), CAR-T/cellular therapy (33%) and stem cell transplant (60%). Interestingly, all 17 patients that received immunotherapy, including 16 that received anti-PD-1/PD-L1 monoclonal antibodies, developed SARS-Cov-2 IgG antibodies (100% seroconversion). These data show differential rates of seroconversion in specific patient groups and bear importance for clinical monitoring and vaccination strategies that are being developed to mitigate the COVID-19 pandemic
Expression and Prognostic Significance of m6A-Related Genes in TP53-Mutant Non-Small-Cell Lung Cancer
Authors: Zhao Zhuochen , Wan Junhu , Guo Manman , Wang Yangxia , Yang Zhengwu , Li Zhuofang , Ming Liang 
Published: December 2020

Abstract
Background: TP53 is an important tumor suppressor gene on human chromosome 17. TP53 mutations have been confirmed in more than 60% of tumor patients' somatic cells. N6-methyladenosine is an enzyme that plays an important role in mRNA splicing, translation, and stabilization. It is a common internal modification of nucleotides, that is regulated by methyltransferases ("writer"), binding proteins ("reader"), and demethylases ("eraser"). However, its role in TP53 mutant non-small-cell lung cancer remains unknown. In this study, we investigated 17 common N-6-Methyladenosine regulators' contributions and prognostic values.Results: Wilcox test showed that 9 of 17 m6A regulators were expressed differently between TP53 mutant and wild type NSCLC (p<0.05). A new way of tumor typing is attempted by consensus clustering. Using univariate cox regression analysis, ALKBH5, HNRNPA2B1 were associated with the prognostic of TP53 mutant patients. Then we built signatures of N-6-Methyladenosine regulators with prognostic ability based on the multivariate cox regression in TP53 mutant cohorts. Moreover, ROC curve showed that this signature could predict the prognostic in mutant cohort well and the riskscore for patients was calculated. With this riskscore, patients with TP53 mutations can be divided into high and low risk groups, and there was a significant difference between two groups. Finally, we found 338 DEGs between high and low risk groups, then GO enrichment analysis, PPI network and GSEA enrichment analysis were used to analysis different signaling pathways between two groups. In conclusion, our study showed m6A regulators can be used as predictive prognostic tools in TP53 mutant patients.Conclusion: Signature consisting of the “erasers” ALKBH5 and “readers” HNRNPA2B1 have potential diagnostic value and prognostic significance in patients with TP53 mutations in non-small cell lung cancer.
Characterization and Transcriptomic Analysis of a Novel Yellow-Green Leaf Wucai (Brassica Campestris L.) Germplasm
Authors: Nie Libing , Zheng Yushan , Zhang Liting , Wu Ying , Zhu Shidong , Hou JinFeng , Chen Guohu , Tang Xiaoyan , Wang Chenggang , Yuan Lingyun 
Published: December 2020

Abstract
Background: Leaf color mutants are the ideal materials to explore the pathways of chlorophyll (Chl) metabolism, chloroplast development, and photosynthesis system. In this study, a spontaneous yellow-green leaf wucai (Brassica campestris L.) mutant “WY16-13” was identified, which exhibited yellow-green leaf color during its entire growth period. However, current understanding of the molecular mechanism underlying Chl metabolism and chloroplast development of “WY16-13” is limited.Results: Comparative transcriptome profiling was performed using leaves from the yellow-green leaf type (WY16-13) and normal green-leaf type (W16-13). A total of 54.12 million (M) (WY16-13) and 56.17 M (W16-13) reads were generated. A total of 40,578 genes were identified from the mapped libraries. We identified 3,882 differentially expressed genes (DEGs) in WY16-13 compared with wild-type W16-13 (i.e., 1,603 upregulated genes and 2,279 downregulated genes). According to the Gene Ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, these DEGs are involved in porphyrin and Chl metabolism [i.e., chlorophyllase (CLH), heme oxygenase (HO), chlorophyll(ide) b reductase (NYC), and protochlorophyllide oxidoreductase (POR) genes], carbohydrate metabolism, photosynthesis, and carbon fixation in photosynthetic organisms. Moreover, deficiency in Chl biosynthetic intermediates in the mutant revealed that the formation of the yellowing phenotype was related to the disorder of heme metabolism.Conclusions: Our results provide valuable insights into Chl deficiency in the yellow-green leaf mutant and a bioinformatics resource for further functional identification of key allelic genes responsible for differences in Chl content.
Towards Service Composition based on Hybrid Bio-Inspired Cloud-based QoS Provisioning Approach.
Authors: Bahgat Waleed , Salam Mahmoud A. , Atwan Ahmed , Badawy Mahmoud , El-Daydamony Eman 
Published: December 2020

Abstract
It has recently become a critical issue to provide software development in a service-based conceptual style for business companies . As a powerful technology for service-oriented computing, the composition of web services is investigated. This offered great opportunities to improve IT industries and business processes by forming new value-added services that satisfy the user’s complex requirements. Unfortunately, many challenges are facing the service composition process. These include the difficulties to satisfy the user’s complex demands, maintaining the performance to be matched with the quality of service (QoS) requirements, and search space reduction for QoS missing or changeable values. Accordingly, this paper proposes a cloud-based QoS provisioning service composition (CQPC) framework to address these challenges. To prove the concept and the applicability of the CQPC framework, a Hybrid Bio-Inspired QoS provisioning (HBIQP) technique is presented for the operation of the CQPC framework modules. The solution space is reduced via utilizing skyline concepts to have faster execution time and keep only reliable and most interesting services. The CQPC framework is equipped with two proposed algorithms: (i) the modified highly accurate prediction (MHAP) algorithm to enhance the prediction of QoS values of the services participating in the composition process, (ii) the MapReduce fruit fly Particle swarm Optimization (MR-FPSO) algorithm to handle composing web services for large scale of data in the cloud environment. The experimental results demonstrate the worthiness of the HBIQP technique to meet the performance metrics more than other state-of-the-art techniques in terms of average fitness value, accuracy, and execution time.