bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey Among General Practitioners and Periodontal Specialists in Norway Documenting a Positive Attitude Towards Guideline‐Based Referral Practise
Authors: Aaen Eirik M. , Bunæs Dagmar F. , Lie Stein A. , Lind Kristian H. , Leknes Knut N. 
Published: December 2024

ABSTRACTAimThe objective of this cross‐sectional survey was to assess the attitude among general practitioners (GPs) and periodontal specialists (PSs) in Norway towards developing and implementing guideline‐based periodontal referral practise.Material and MethodsA multiple‐choice questionnaire was distributed online to a sample of professionally active GPs and PSs. The survey included questions on demographics, practise profile, proficiency and insight among oral healthcare providers, periodontal referral patterns, and attitude on establishing guideline‐based referral practise. Logistic regression analyses were employed to estimate associations between dependent and selected independent variables. Inverse probability weights (IPW) were applied to adjust for non‐response in the logistic regression models.ResultsAnalyses were based on answers from 353 GPs and 49 PSs. The majority of GPs (77.9%) considered periodontal referral guidelines as a useful tool if they were available, and 59.2% of PSs expressed a positive attitude for implementing guideline‐based referral practise to prevent premature or delayed referrals. In total, 93.9% of PSs reported that patients with periodontitis were being referred from GPs too late either frequently or sometimes. Females tended to be more interested in utilising referral guidelines than males (odds ratio, OR = 2.89, p < 0.001). Older GPs and those with increasing years of practising, were less interested in using referral guidelines than younger and more inexperienced GPs (both p < 0.05).ConclusionsThe findings document a positive attitude and significant need for developing and implementing periodontal referral guidelines among GPs and PSs, ensuring timely identification and referral of patients with periodontitis.
Cover Image
Authors: Galarraga‐Vinueza Maria Elisa , Barootchi Shayan , Mancini Leonardo , Sabri Hamoun , Schwarz Frank , Gallucci German O. , Tavelli Lorenzo 
Published: December 2024

The cover image is based on the article Echo‐intensity characterization at implant sites and novel diagnostic ultrasonographic markers for peri‐implantitis by Maria Elisa Galarraga‐Vinueza etal., https://doi.org/10.1111/jcpe.13976.image
In situ observations confirm that the wrought‐iron butterflyfish Chaetodon daedalma is a facultative corallivore
Authors: Baird Andrew H. , Pratchett Morgan S. , Reimer James D. 
Published: December 2024

AbstractHere, we provide the first in situ observations of foraging habitats of Chaetodon daedalma, which is endemic to the subtropical north‐west Pacific. Overall, 62.4% of bites were from the substratum, 30.7% from scleractinian corals, 3.3% from crustose coralline algae, 2.1% from macroalgae, and 1.2% from hydroids. The range in the percentage of bites taken from scleractinian corals among individuals was 0%–76%, and no fish fed exclusively on coral. Our in situ feeding observations confirm that the species is a facultative corallivore.
Application of forecast‐informed reservoir operations at US Army Corps of Engineers dams in California
Authors: Forbis Joe , Ly Cuong 
Published: December 2024

AbstractThe US Army Corps of Engineers (USACE) prescribes flood control operations for reservoirs it regulates in watershed‐specific water control manuals (WCMs), which can be decades‐old and may not capture changed conditions in the watersheds or include the benefit of state‐of‐the‐science weather and streamflow prediction. Considering the specific characteristics of a reservoir, forecast‐informed reservoir operations (FIRO) may be used to enhance flood risk reduction, improve water availability, and achieve other benefits. The first FIRO pilot project at Lake Mendocino in California focused on determining if water supply reliability could be improved using FIRO without increasing flood risk. The final report concluded that FIRO concepts could indeed improve water supply reliability while enhancing flood risk reduction. Subsequently, USACE chose additional reservoir systems in California with different characteristics as additional pilot study locations to further investigate FIRO concepts. These successful FIRO efforts have provided justification to continue its expansion beyond the initial pilot sites. The lessons learned from the FIRO pilot projects are being used to inform the development of the FIRO Screening Process, a screening level framework intended to scale up the implementation of FIRO. The lessons learned could support FIRO implementation at suitable USACE reservoirs by updating WCMs.
Development of Deep Learning–Based Virtual Lugol Chromoendoscopy for Superficial Esophageal Squamous Cell Carcinoma
Authors: Toya Yosuke , Suzuki Sho , Monno Yusuke , Arai Ryo , Dohmen Takahiro , Eizuka Makoto , Okutomi Masatoshi , Matsumoto Takayuki 
Published: December 2024

ABSTRACTBackgroundLugol chromoendoscopy has been shown to increase the sensitivity of detection of esophageal squamous cell carcinoma (ESCC). We aimed to develop a deep learning–based virtual lugol chromoendoscopy (V‐LCE) method.MethodsWe developed still V‐LCE images for superficial ESCC using a cycle‐consistent generative adversarial network (CycleGAN). Six endoscopists graded the detection and margins of ESCCs using white‐light endoscopy (WLE), real lugol chromoendoscopy (R‐LCE), and V‐LCE on a five‐point scale ranging from 1 (poor) to 5 (excellent). We also calculated and compared the color differences between cancerous and non‐cancerous areas using WLE, R‐LCE, and V‐LCE.ResultsScores for the detection and margins were significantly higher with R‐LCE than V‐LCE (detection, 4.7 vs. 3.8, respectively; p < 0.001; margins, 4.3 vs. 3.0, respectively; p < 0.001). There were nonsignificant trends towards higher scores with V‐LCE than WLE (detection, 3.8 vs. 3.3, respectively; p = 0.089; margins, 3.0 vs. 2.7, respectively; p = 0.130). Color differences were significantly greater with V‐LCE than WLE (p < 0.001) and with R‐LCE than V‐LCE (p < 0.001) (39.6 with R‐LCE, 29.6 with V‐LCE, and 18.3 with WLE).ConclusionsOur V‐LCE has a middle performance between R‐LCE and WLE in terms of lesion detection, margin, and color difference. It suggests that V‐LCE potentially improves the endoscopic diagnosis of superficial ESCC.
Comparison of Risk‐Scoring Models to Predict Gastrointestinal Bleeding in Patients With Direct Oral Anticoagulants
Authors: Kim Ilsoo , Kim Joon Sung , Cheung Dae Young , Kim Byung‐Wook , Hou Jong‐Uk 
Published: December 2024

ABSTRACTBackground and AimThe risk of gastrointestinal bleeding (GIB) remains a concern with the use of direct oral anticoagulants (DOAC). We evaluated the efficacy of four risk‐scoring models (HAS‐BLED, ATRIA, VTE‐BLEED, and ORBIT) in predicting GIB according to the concomitant use of antiplatelet therapy in DOAC users.MethodsPatients prescribed DOAC between December 2014 and October 2020 were enrolled in two university‐affiliated hospitals. The performance of the four models was compared based on the concomitant use of antiplatelet therapy. The primary outcomes were likelihood ratios and the area under the receiver operating characteristic (AUROC) curve to predict GIB.ResultsA total of 4494 patients were included in the study. The AUROC values for the entire cohort were 0.643 (95% CI: 0.601–0.686) for HAS‐BLED, 0.693 (95% CI: 0.649–0.737) for ATRIA, 0.708 (95% CI: 0.665–0.750) for VTE‐BLEED, and 0.709 (95% CI: 0.667–0.751) for ORBIT. The AUROC for all scoring models increased in patients without antiplatelet therapy compared to the entire cohort and patients with antiplatelet therapy. The specificity and diagnostic accuracy for all scoring models increased in patients without antiplatelet therapy compared to patients with antiplatelet.ConclusionsOur results confirmed that current risk‐scoring models for predicting GIB perform better in patients without antiplatelet therapy than in those on concomitant antiplatelet therapy. This suggests that future risk prediction models should consider the concomitant use of antiplatelet therapy for diagnostic accuracy.
Analysis of Hospitalization Cases for Filler Injection Complications: A Five‐Year Retrospective Study Among Iranian People
Authors: Ehsani Ala , Falakian Setareh , Ehsani Amirhoushang , Hamzelou Shahin , Balighi Kamran , Razavi Zahra , Aryanian Zeinab , Khayyat Azadeh , Hatami Parvaneh 
Published: December 2024

ABSTRACTIntroductionThe skin is the largest organ system with many important clinical functions. Due to the increase in demand for cosmetic procedures and consequently the increase in complications from filler injections, this research aims to review the hospitalization cases involving filler complications.MethodologyThis study retrospectively and cross‐sectionally reviews patient records hospitalized between the years 2016 to 2020, focusing on demographics (age, gender, residence), type of filler, type of complications, onset and duration of complications, duration of hospital stay, the person who administered the injection, and treatment outcomes. The goal is to understand the complications, prognosis, and potential risk factors.ResultsA total of 58 patients were hospitalized due to complications arising from filler injections between 2016 and 2020. The average age of patients was approximately 37.79 years, ranging from 15 to 62 years old. A majority, 94.8%, were female and 62.1% were married. The most common filler used was hyaluronic acid, accounting for 81% of cases. Complications included cellulitis in 41.4% of cases, abscesses in 29.3%, granulomatous inflammation in 19%, and necrosis in 10.3%. The shortest hospital stay was 1 day and the longest was 9 days, with an average stay of approximately 2.33 days. In 65.5% of the cases, the injections were administered by medical professionals, and in 34.5%, by individuals without medical credentials. Married individuals generally sought hospital care later than others. Severe complications were more likely to occur when injections were administered by nonprofessionals. The time to seek medical attention was shorter for severe complications than for moderate ones. There were no deaths among the cases studied.ConclusionThe study highlights the variation in complication severity associated with filler injections performed by nonmedical personnel, emphasizing the importance of prohibiting such practices. Educating patients about the early signs of complications can significantly reduce severe outcomes and decrease antibiotic resistance.
Short‐Term Responses of Native (Perna viridis, Linnaeus 1758) and Non‐Native (Mytella strigata, Hanley 1843) Mussels to Independent and Combined Effects of Lowered pH Level and Elevated Temperature
Authors: Cabiguin Maryjune M. , Moteclaro Harold M. , Juinio‐Meñez Marie Antonette 
Published: December 2024

ABSTRACTChanges in environmental conditions can influence the success of marine biological invasions. This study assessed the independent and combined acute short‐term effects of increased temperature (OW) and lowered pH (OA) simulating future ocean conditions on a native, Perna viridis, and non‐native, Mytella strigata, mussel species. There were four treatment combinations: Future (combination of ocean warming and ocean acidification), Ambient conditions, ocean acidification (OA), and ocean warming (OW). Survival and byssus thread regeneration in all treatments were measured daily for 7 days, while net calcification rate was calculated from the start and end of the experiment. Net calcification rate (NCR) was lowest under OA treatment. Likewise the low total alkalinity at the start of the experiment under OA suggests that the mussels experienced greater physiological stress. The higher survival rate of green mussels and the increase in the byssus regeneration rate over time in all treatments demonstrated that it can acclimate better to acute short‐term temperature and pH stress. The very low survival of M. strigata in OA compared to other treatments indicates its high sensitivity to low pH stress. However, surviving charru individuals maintained high byssus thread regeneration in all treatments. Overall, results suggest that M. strigata may not displace the native green mussels', P. viridis, higher tolerance to acute short‐term exposure to elevated temperatures and low pH, but can co‐exist in lower densities. This is the first study to compare the short‐term physiological responses of a sympatric non‐native and native mussel species under experimentally induced stress conditions. Longer‐term studies on the population dynamics of these species are essential to assess the potential success of these species under changing and variable environmental conditions.
Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood
Authors: Song Shuaihua , Zhang Liyuan , Du Hanze , Zhang Yuelun , Jiang Yue , Li Daowei , Hu Yi , Chen Shi , Zhu Huijuan , Shan Guangliang , Pan Hui 
Published: December 2024

ABSTRACTThe relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass index (BMI), fat mass index (FMI), and fat‐free mass index (FFMI) were calculated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood lipids, and fasting blood glucose (FBG) were measured. Multivariate adjusted linear regression models were used to assess the association between famine and outcome. Our results shown that fetal‐exposed group had higher BMI and FMI (β > 0). Childhood‐exposed group showed an average decrease of 0.08 standard deviation (SD) in FFMI, and adolescence‐exposed group had lower BMI and FFMI than non‐exposed group. SBP were 0.38 SD higher in fetal‐exposed group, 0.58 SD higher in childhood‐exposed group and 0.85 SD higher in adolescence‐exposed group than non‐exposed group. Famine‐exposed groups had higher total cholesterol (TC), low density lipoprotein‐cholesterol (LDL‐C), and FBG levels (β > 0). For females with famine exposure, they had a higher BMI, FMI, LDL‐C, TG, and TC than males. Overall, early famine exposure is associated with increased blood pressure, LDL‐C, TC, and FBG. Muscle mass loss in adulthood associated with childhood and adolescence famine exposure. Famine‐exposed females appear to have higher levels of body fat and blood lipids.
Understanding the Past to Preserve the Future: Genomic Insights Into the Conservation Management of a Critically Endangered Waterbird
Authors: Chen Qing , Lin Hongzhou , Zheng Chenqing , Mudrik Elena A. , Kashentseva Tatiana A. , Cheng Yalin , Wang Zhiru , Zhou Haiyan , Zhou Haixiang , Wang Wenjuan , Liu Yang 
Published: December 2024

ABSTRACTTo ensure the success of genetic rescue, we must minimise the potential negative effects of outbreeding depression that may arise from selecting source populations. The difficulty in assessing the likelihood of outbreeding depression has hindered its consideration in endangered species conservation. However, genomic research offers feasible indications. Here, we conduct conservation genomic analyses on the East Asian (EA) population and the relict Western/Central Asian (WCA) population of the critically endangered Siberian crane (Leucogeranus leucogeranus). We aim to assess genetic rescue's potential advantages and disadvantages between the two populations. Our analysis shows genomic evidence of limited genetic differentiation between them. The persistent decline in population size due to historical climatic oscillations leads to a decrease in genetic diversity and an increase in inbreeding. The WCA population has excessive deleterious homozygous mutations than the EA population, suggesting suffering from inbreeding depression resulting from less effective purifying selection. Forward simulations support the increase in genetic load due to elevated levels of inbreeding compromises fitness during population collapse. We strongly recommend an urgent genetic rescue for the WCA population through population supplementation from the EA population. However, the continuous monitoring of fitness outcomes is required through captive breeding. This work provides useful insights into the genetic management of a critically endangered species and emphasises the importance of evaluating the likelihood of outbreeding depression through genomic approaches.
The Genetic Architecture of Local Adaptation and Reproductive Character Displacement in Scutiger boulengeri Complex (Anura: Megophryidae)
Authors: Lin Xiuqin , Yan Chaochao , Wang Yuanfei , Huang Sining , Yu Haoqi , Shih Chungkun , Jiang Jianping , Xie Feng 
Published: December 2024

ABSTRACTSpeciation is a continuous process driven by barriers to gene flow. Based on genome‐wide SNPs (single nucleotide polymorphisms) of 190 toads from 31 sampling sites of Scutiger boulengeri complex, we found evidence for monophyly which represented a continuous speciation process of at least six lineages in S. boulengeri, which radiated and exhibited varying degrees of divergence and gene flow. The SNP‐based phylogenetic tree was largely discordant with the multilocus mitochondrial tree (i.e., S. mammatus and S. glandulatus nested in the lineages of S. boulengeri) published before. The Min Mountains (MM) and Qinghai‐Tibet Plateau (QTP) lineages differ fundamentally in habitat (i.e., elevation) and morphology (i.e., SVL), we detected signatures of potential high‐altitude and cold adaptation genes in QTP (vs. MM). We found the evidence of reproductive trait disparity (i.e., SVL and nuptial pads) is key to promoting sympatric rather than allopatric species pairs. In addition, we identified selection signals for genes related to sympatric character displacement, genes linked to obesity‐related traits, nuptial spines morphology and enlarged chest nuptial pads in S. mammatus (vs. QTP group of S. boulengeri). Our study provided new insight and paradigm for a varied speciation pattern from local adaptation of allopatry to sympatric character displacement in the S. boulengeri complex.
The SnRK2.2‐ZmHsf28‐JAZ14/17 module regulates drought tolerance in maize
Authors: Liu Lijun , Tang Chen , Zhang Yuhan , Sha Xiaoyu , Tian Shuaibing , Luo Ziyi , Wei Guocheng , Zhu Li , Li Yuxin , Fu Jingye , Luo Peigao , Wang Qiang 
Published: December 2024

Summary
Abscisic acid (ABA) and jasmonic acid (JA) are important plant hormones in response to drought stress. We have identified that ZmHsf28 elevated ABA and JA accumulation to confer drought tolerance in maize; however, the underlying mechanism still remains elusive.
The knockout line zmhsf28 is generated to confirm the positive role of ZmHsf28 in drought response. Multiple approaches are combined to reveal protein interaction among ZmHsf28, ZmSnRK2.2 and ZmJAZ14/17, which form a regulatory module to mediate maize drought tolerance through regulating ABA and JA key biosynthetic genes ZmNCED3 and ZmLOX8.
Upon drought stress, zmhsf28 plants exhibit weaker tolerance than the WT plants with slower stomatal closure and more reactive oxygen species accumulation. ZmHsf28 interacted with ZmSnRK2.2 physically, resulting in phosphorylation at Ser220, which enhances binding to the heat shock elements of ZmNECD3 and ZmLOX8 promoters and subsequent gene expression. Meanwhile, ZmMYC2 upregulates ZmHsf28 gene expression through acting on the G‐box of its promoter. Besides, ZmJAZ14/17 competitively interact with ZmHsf28 to interfere with protein interaction between ZmHsf28 and ZmSnRK2.2, blocking ZmHsf28 phosphorylation and impairing downstream gene regulation.
The ZmSnRK2.2‐ZmHsf28‐ZmJAZ14/17 module is identified to regulate drought tolerance through coordinating ABA and JA signaling, providing the insights for breeding to improve drought resistance in maize.
Genetic Mutations Leading to Dento‐Maxillofacial Abnormalities in Mice: A Systematic Review
Authors: Zhao Zuodong , Van Bruwaene Achiel , Lievens Ella , De Laet Marie , Attanasio Catia , Pedano Mariano Simón , Cadenas de Llano‐Pérula María 
Published: December 2024

ABSTRACTIntroductionTo systematically review the available literature reporting on genetic mutations leading to dento‐maxillofacial malformations in mice.Materials and MethodsAn electronic search was performed across Embase, PubMed, Web of Science, and Scopus databases up to May 2024, targeting all in vivo studies on gene mutations causing dento‐maxillofacial deformities in mice. Studies reporting oral clefts were excluded. Data collected included genetic background, sex distribution, observation times, sample sizes, interventions, affected genes, zygosity, dento‐maxillofacial anomalies, and associated human syndromes. Risk of bias was evaluated using the SYRCLE tool.ResultsOf 12,968 articles, 215 were included. The most common genetic background was C57BL6/J (B6) (n = 83), and knock‐out was the most common intervention (n = 142). A total of 172 studies included homozygous mice. The five most studied genes were Amelx, Bmp‐2, Dspp, Enam, and Runx2. Dento‐alveolar anomalies were more commonly reported (n = 175) than skeletal (n = 65). Skeletal anomalies were mostly related to micrognathia (n = 14), agnathia (n = 5), dysplasia (n = 1), or reduced jaw size (n = 14). Risk of bias was moderate.ConclusionsKey genes such as Amelx, Bmp‐2, Dspp, Enam, and Runx2 implicated in dento‐maxillofacial abnormalities in mice, detailing the most prevalent skeletal and dento‐alveolar anomalies. These findings offer insights for developing gene therapy and diagnosing congenital malformations.
The Maddox rod: Revisiting the optics
Authors: Habib Malak , Andrew Nicholas Howard 
Published: December 2024

AbstractThe Maddox rod is a staple in the assessment of strabismus. However, its optics mechanism is puzzling. How is it that an orthogonal line focus is formed? Surprisingly, few texts offer an explanation and those that do either provide insufficient detail, contain misleading information or are difficult to follow. There is a prevalent misconception that multiple cylinders are required for the orthogonal line focus to appear. However, this is untrue; Maddox himself only used a single cylinder when he first described the phenomenon. Herein, we review the optics explanations provided in a sample of texts and offer an accurate explanation using the biplanar principle of astigmatic refraction.