bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Centre Profile: The Provincial Health Data Centre of the Western Cape Province, South Africa
Authors: Boulle Andrew , Heekes Alexa , Tiffin Nicki , Smith Mariette , Mutemaringa Themba , Zinyakatira Nesbert , Phelanyane Florence , Pienaar Cara , Buddiga Kasturi , Coetzee Eduan , Van Rooyen Renier , Dyers Robin , Fredericks Naadir , Loff Adam , Shand Lesley , Moodley Melvin , De Vega Ian , Vallabhjee Krish 
Published: November 2019

Introduction
The Western Cape Provincial Health Data Centre (PHDC) consolidates person-level clinical data across government services, leveraging sustained investments in patient registration systems, a unique identifier, and maturation of administrative and clinical digital health systems.
Objectives
The PHDC supports clinical care directly through tools for clinicians which integrate patient data or identify patients in need of interventions, and indirectly through supporting operational and epidemiological analyses.
Methods
The PHDC is housed entirely within government. Data are processed from a range of source systems, usually daily, through distinct harmonisation and curation, beneficiation, and reporting processes. Linkage is predominantly through the unique identifier which doubles as a pervasive folder number, augmented by other identifiers. Further data processing includes triangulation of multiple data sources for enumerating health conditions, with assignment of certainty levels for each enumeration. Outputs include patient-specific email alerts, a web-based consolidated patient clinical viewing platform, filterable line-listings of patients with specific conditions and associated characteristics and outcomes, management reports and dashboards, and data releases in response to operational and research data requests. Strict architectural, administrative and governance processes ensure privacy-protection.
Results
In the past decade 8 million unique people are recorded as having sought healthcare in the provincial public sector health services, with current utilisation at 15 million attendances or admissions a year. Cross-sectional enumeration of health conditions includes over 430 000 people with HIV, 500 000 with hypertension, 235 000 with diabetes. 110 000 pregnancies and 54 000 patients with tuberculosis are enumerated annually. Each year over 50 data requests are processed for internal and external requesters in accordance with data request and release governance processes.
Conclusions
The single consolidated environment for person-level health data in the Western Cape has created new opportunities for supporting patient care, while improving the governance around access to and release of sensitive patient data.
STUDI KOMPARASI KEJADIAN HIPERTENSI PADA PELATIHAN TRAINING OF TRAINER KELUARGA SEHAT DI BBPK CILOTO DAN BAPELKES BATAM
Authors: Supriyono Supriyono 
Published: November 2019

Penelitian ini bertujuan untuk membandingkan kejadian hipertensi secara empiris pada dua lokasi yang meliputi hubungan karakteristik (usia, jenis kelamin dan tingkat pendidikan) dengan kejadian hipertensi pada peserta pelatihan TOT Keluarga Sehat. Penelitian ini bersifat observasional dengan pendekatan cross sectional. Populasi dalam penelitian ini menggunakan sampel jenuh, dimana sampel yang digunakan adalah seluruh peserta yang mengikuti pelatihan, yaitu sebanyak 60 responden, yang tersebar di 2 lokasi yaitu BBPK Ciloto dan Bapelkes Batam, masing-masing 30 responden. Untuk mengetahui hubungan antar variabel dengan menggunakan uji statistik Sperman Rank. Sedangkan untuk mengetahui perbandingan antar dua populasi adalah dengan distribusi frekuensi dari variabel-variabel. Dalam penelitian ini diperoleh hasil tidak ada hubungan yang signifikan secara statistik antara usia, jenis kelamin dan tingkat pendidikan dengan hipertensi. Namun bila dilihat dari masing-masing variabel, maka peserta pelatihan dari BBPK Ciloto mempunyai kejadian hipertensi lebih baik dibandingkan dengan peserta dari Bapelkes Batam. Disarankan agar setiap lembaga pendidikan dan pelatihan menyediakan poliklinik yang dilengkapi dengan tenaga medis dan paramedis.
ANALISIS PROMOSI RANDAI (WARISAN BUDAYA TAK BENDA) SEBAGAI KEGIATAN EKONOMI KREATIF DALAM RANGKA RIAU SEBAGAI “HOME LAND MELAYU “ ( STUDI PADA RANDAI KUANTAN BASERAH KUANTAN SINGINGI )
Authors: Sosiady Mulia , Syah Erman 
Published: November 2019

Mulia SosiadyDosen Prodi S1 Manajemen Fekonsos UIN Suska RiauEmail : mulia_sosiady@yahoo.com ErmansyahDosen Prodi S1 Manajemen Fekonsos UIN Suska RiauEmail : erman_uinsuska@yahoo.com Penelitian ini berlokasi Kecamatan Baserah Kab Kuantan Singingi dimana disana banyak Group Randai Kuantan Randai Kuantan merupakan sebuah kesenian unik yang memperlihatkan berbagai cerita rakyat, yang dibawakan dalam sebuah pertunjukan teater seni tradisional. Randai yang pertama dipertunjukkan di daerah Kuansing adalah Randai Cindur Mato. Randai ini dimainkan oleh perantau Minangkabau bersama-sama orang Kampar. Pertunjukan Randai mereka hampir serupa semuanya dengan pertunjukkan Randai di Minangkabau. Randai Kuantan, pada dasarnya adalah salah satu kesenian khas rakyat yang berkembang diprovinsi Riau. Banyak sekali keunikan yang dapat kita lihat pada tradisi ini. Kesenian ini, juga dimainkan oleh sekelompok orang yang berjumlah sekitar 15 hingga 30 orang dalam sekali pementasan. Terdapat beberapa peran penting, seperti tokoh cerita serta peran pendukung lainnya, dalam pertunjukan kesenian yang juga dimainkan oleh mayoritas anak muda yang juga sering disebut dengan nama Randai Bujang Gadi tersebut.Beberapa orang dalam kelompok pementasan kesenian Randai Kuantan, juga bertugas sebagai pemain alat musik tradisional. Diantara alat musik yang mengiringi berbagai kegiatan pertunjukan tersebut, yakni Piaual, Gedang, Biola, Seruling, Harmonika, Rebana, Serta alat musik Lapri, guna mengiringi berbagai nyanyian lagu daerah yang dibawakan dalam pertunjukan kesenian Randai Kuantan.
DAMPAK CORPORATE GOVERNANCE TERHADAP KONSERVATISMA AKUNTANSI DI PERUSAHAAN YANG LISTING PADA JAKARTA ISLAMIC IDEXS
Authors: Rahmi Febri 
Published: November 2019

Penerapan corporate governance merupakan salah satu faktor yang mampu membangun dan mewujudkan pasar modal yang sehat. Perusahaan yang telah menerapkan corporate governance yang baik akan mendapat penghargaan pada nilai saham atau premium sebesar 20% - 30%. Negara yang memiliki pasar modal yang besar akan memiliki pertumbuhan ekonomi yang lebih cepat di masa datang
PENGUATAN EKONOMI MASYARAKAT MELALUI PENGELOLAAN KELEMBAGAAN BADAN USAHA MILIK DESA MENUJU ASEAN ECONOMIC COMMUNITY 2015
Authors: Alkadafi Muammar 
Published: November 2019

Badan Usaha Milik Desa (BUM Desa) merupakan pilar kegiatan ekonomi di desa yang berfungsi sebagai lembaga sosial (social institution) dan komersial (commercial institution), BUM Desa sebagai lembaga sosial berpihak kepada kepentingan masyarakat melalui kontribusinya dalam penyediaan pelayanan sosial. Sedangkan sebagai lembaga komersial bertujuan mencari keuntungan melalui penawaran sumberdaya lokal (barang dan jasa) ke pasar. Pembentukan BUM Desa di desa Selensen mengacu pada Peraturan Daerah Kabupaten Indragiri Hilir Nomor 09 Tahun 2009 tentang Pedoman Pembentukan Badan Usaha Milik Desa. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan fokus penelitian: (1) prosess pembentukan dan pelaksanaan kegiatan kelembagaan Badan Usaha Milik Desa (2) peran kelembagaan Badan Usaha Milik Desa dalam pengembangan ekonomi pedesaan. Hasil penelitian ini ialah, pelaksanaan kegiatan Badan Usaha Milik Desa di Desa Selensen sudah terlaksana dengan baik sesuai dengan tujuan pendirian kelembagaan, dan dapat dikatakan cukup berhasil. Kemudian, kelembagaan BUM Desa telah memberikan kontribusi positif bagi penguatan ekonomi di pedesaan dalam mengembangkan perekonomian masyarakat.
ANALISIS HAMBATAN DALAM PENGEMBANGAN BUM DESA
Authors: Jaya Rony , Rafi Mhd. 
Published: November 2019

Pasal 87 ayat 2 UU Desa menyebutkan BUM Desa dikelola dengan semangat kekeluargaan dan kegotongroyongan. Fenomena umum yang terjadi di banyak BUM Desa setelah dibentuk adalah kesulitan mengembangkan usaha. Sebagaimana yang dialami oleh BUM Desa Rempak Maju Jaya Kampung Rempak Kecamatan Sabakauh Kabupaten Siak. Tujuan penelitian ini adalah untuk mengetahui apa saja yang menjadi hambatan dalam pengembangan BUM Desa Rempak maju jaya. Metode penelitian menggunakan pendekatan deskriptif kualitatif dengan teknik pungumpulan data wawancara dan dokumentasi. Berdasarkan temuan penelitian hambatan dalam pengembangan BUM Desa Rempak Maju jaya diantaranya adalah rendahnya kapasitas dan kompentensi SDM pengelola yang masih minim pengalaman dan jiwa wirausaha sehingga berdampak pada stagnasi unit usaha BUM Desa. Selanjutnya adalah Faktor komunikasi yang tidak efektif dan terbatasnya beberapa arus informasi diseputaran elit desa. Perbedaan penafsiran terhadap regulasi terkait BUM Desa, rendahnya partisipasi dan dukungan masyarakat serta skala dan jangkauan usaha yang ada masih terbatas
ANALISIS KEPUASAN PELANGGAN PADA BENGKEL ANTO MOTOR PEKANBARU
Authors: Rachmadi M. 
Published: November 2019

Penelitian ini dilakukan Pada Bengkel Anto Motor Pekanbaru. Penulis melakukan penelitian ini untuk mengetahui faktor-faktor apa yang mempengaruhi kepuasan pelanggan pada Bengkel Anto Motor Pekanbaru .Hipotesis penelitian ini dirumuskan sebagai berikut : “diduga bahwa tingkat kepuasan pelanggan pada Bengkel Anto Motor Pekanbaru telah sesuai dengan harapan pelanggan”.Penelitian ini memerlukan data primer dan data sekunder, dalam penelitian ini teknik pengambilan sampel secara Purposive Sampling, dengan menggunakan rumus Slovin, dimana teknik penentuan sampel dengan pertimbangan tertentu yaitu orang yang benar-benar pelanggan Bengkel Anto Motor Pekanbaru. Dalam melakukan analisis data penulis menggunakan metode analisis Deskriptif kuantitatif dengan menggunakan Importance Performance Analysis (Analisis Tingkat Kepentingan dan kinerja/kepuasan pelanggan).Pada penelitian ini variabel yang dibahas yaitu Bukti fisik(tangible), Jaminan(assurance), Kehandalan(realibility), Ketanggapan(responsiveness) dan Empati(emphaty)Dari penelitian ini diperoleh hasil sebagai berikut : Bukti fisik (tangible), Jaminan(assurance), Kehandalan (reliability), Ketanggapan (responsiveness) dan Empati (emphaty) mempengaruhi kepuasan Pelanggan pada Bengkel Anto Motor Pekanbaru, hal ini terlihat dari hasil olahan data, ini berarti variabel-variabel tersebut memiliki pengaruh yang erat secara parsial terhadap kepuasan pelanggan pada Bengkel Anto Motor Pekanbaru.
INVESTIGASI PERSEPSI MAHASISWA AKUNTANSI TERHADAP INTERNATIONAL FINANCIAL REPORTING STANDARDS
Authors: Syafei Jasmina 
Published: November 2019

Penelitian ini adalah untuk menginvestigasi persepsi mahasiswa akuntansi terhadap International Financial Reporting Standars (IFRS). Hasilnya menunjukkan tidak terdapat perbedaan tingkat pengetahuan mahasiswa,terhadap pemahaman IFRS. Berdasarkan usia tidak terdapat perbedaan tingkat pengetahuan antar kelompok usia dalam memahami IFRS. Berdasarkan tahun masuk universitas, ada perbedaan tingkat pengetahuan mahasiswa terhadap pemahaman IFRS. Dalam analisis regresi tingkat pengetahuan berpengaruh negative dan signifikan terhadap keinginan untuk mengambil kelas tentang IFRS. Sedangkan untuk variabel INTEREST, minat berpengaruh positif dan signifikan terhadap keinginan mengambil kelas. Begitu pula dengan Persepsi mahasiswa mengenai dampak IFRS terhadap kinerja keuangan (PERCEPTION1) berpengaruh positif terhadap keinginan mengambil kelas. Sedangkan variabel PERCEPTION2, berkiatan dengan persepsi kinerja finansial akan menimbulkan keinginan untuk mengambil kelas terhadap IFRS. Namun hasil pengujian tidak signifikan Hasil yang serupa juga ditunjukkan oleh variabel PERCEPTION3, variabel persepsi mahasiswa mengenai pengaruh terhadap stakeholder tidak berpengaruh secara signifikan.
Extraction of Exosomes from Glioblastoma Multiforme Patients’ Blood Plasma
Authors: Gareev I. F. , Beylerli O. A. , Zhao Sh. , Yang G. , Sun J. , Beilerli A. T. , Safin Sh. M. 
Published: November 2019

Introduction. Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumour in adults associated with a poor prognosis. Exosomes have been shown to be useful non-invasive biomarkers for the diagnosis and prognosis of tumours, GBM included. Exosomes play a role of biological carriers which can perform various tasks through various signalling pathways of carcinogenesis, such as PI3K/AKT, SOX2, PTEN, ERK and STAT3.Materials and methods. Exosomes were isolated from blood plasma taken from patients diagnosed with GBM prior to surgical resection.Results and discussion. Plasma exosomes from patients with GBM had spherical shape and varied in size from 40 to 100 nm matching the exosomes’ morphological characteristics. The combination of ultrafiltration and double ultracentrifugation makes it possible to extract exosome examples from plasma without the presence of contaminating particles over 100 nm in size; the shape and size of these vesicles match the characteristics of exosomes isolated from other biological fluids.Conclusion. The experimental protocol for the extraction of exosomes from GBM patients’ plasma described here proves effective as a method used to ensure the purity of exosomes. Applying this method offers further opportunities for research into the role of exosomes in GBM pathogenesis. Equally this method can be used in research involving other human pathologies.
Variações no léxico disponível de 'A Fala': plantas e animais
Authors: Flores Pérez Tamara 
Published: November 2019

No vale de Xálima (Cáceres) falam-se três variedades (manhego em São Martinho de Trebelho, lagarteiro em As Elhas e valverdeiro em Valverde do Fresno) de uma língua cujo glotónimo consensual, embora controverso, é A Fala. Desde o boom dos anos 90, foram muitos os investigadores que realizaram estudos sobre estas variedades; todavia, a maioria deles centraram-se em determinar a origem e adscrição linguística das mesmas, pelo que ainda são necessários mais trabalhos descritivos em todos os campos da língua, especialmente no léxico.A partir de uma recolha do léxico disponível de A Fala do vale de Xálima, propomo-nos analisar as variações encontradas em dois centros de interesse: animais e plantas.
Carta do 2º Marquês do Lavradio escrita ao Governador da Capitania de São Paulo, ano de 1777
Authors: Franco Daví Lopes 
Published: November 2019

O códice 10631 disponível no repositório da Biblioteca Nacional de Portugal http://purl.pt/14392 é um documento que contém relatos do 2º Marquês do Lavradio, 11º vice-rei do Brasil para os governadores de várias capitanias do Brasil, no século XVII. Esse códice é composto por 169 cartas. Desse grupo, 10 endereçadas ao governador da capitania de São Paulo — Senhor Martim Lopez Lobo de Saldanha, já foram feitas edições semidiplomáticas fac-similares durante minha Iniciação Científica. Essas missivas tratam de assuntos relacionados ao governo e de suas defesas perante às ameaças de ataque das forças castelhanas. Nesta publicação, apresentaremos, de forma simples e sucinta uma dessas cartas. Vale destacarmos que esse texto é uma produção contextualizada, portadora de acontecimentos históricos importantes para a história do Brasil e merece ser preservada de maneira acessível, a fim de que outros pesquisadores de áreas diversas tenham acesso à essa fonte primária.
“Appreciate me and i will be your good soldier”. The exploration of antecedents to consumer citizenship
Authors: Dewalska-Opitek Anna , Mitręga Maciej 
Published: November 2019

Abstract
Customer citizenship behaviour (CCB) is an important consumer trend observed in the contemporary market. It may be described as an extra-role, voluntary behaviour performed in favour of other customers or companies. One of the CCB dimensions, namely, providing customer feedback to company offering, overlaps with value co-creation as a booming marketing concept. Our knowledge about factors determining this behaviour is relatively week. Trying to fill the gap, this paper discusses inclination for value co-creation among customers on the basis of literature review and explorative research. This explorative study aims to identify some company-related and customer-related antecedents to customer citizenship behaviour in the form of value co-creation in favour of companies. The theoretical deliberation is based on a critical literature review. The empirical part of the paper is based on explorative research in the form of a survey of 105 non-randomly selected customers. Aiming to identify the key drivers for customer inclination to participate in value co-creation, the exploratory factor analysis (EFA) was conducted; next, the quality of factor structure was assessed with the help of SmartPLS 3.0 using standard measures of validity; and finally, structural links between the inclination to co-create and distinct antecedents were estimated using the partial least square structural equitation modelling technique (PLS_SEM). The factor analysis suggested distinguishing two aspects of customer co-creation, i.e., either initiated by companies (Organised Co-Creation) or by customers (Spontaneous Co-creation). The estimated PLS structural model shows that only some casual paths were found statistically significant, i.e., the appreciation showed by companies towards customers engaging in the organised co-creation process (as extrinsic motivation) and customer innovativeness, as well as the fulfilment of the need for stability (as intrinsic motivation) with regards to spontaneous co-creation. The ex-post moderation analysis with the help of the PLS_MGA algorithm enabled to identify gender as the factor potentially explaining inter-group differences in the structural model.
Managerial reporting by food production companies in Slovakia in 2017
Authors: Pakšiová Renáta , Lovciová Kornélia 
Published: November 2019

Abstract
Corporate reporting on non-financial information has been currently gaining much more interest compared to the past. Most food enterprises believe that performing responsibly and showing an interest in society and the environment will produce a profit and benefit them as well as society. Such cases, in which enterprises report on non-financial information, were the subject of this research. The study aims to discover the managerial reporting of 2017 on the social and environmental effects of food companies in Slovakia to better understand problems in this regard. 2017 was the first year when enterprises were required to draft annual reports containing non-financial information following the amendment to the Slovak law that resulted from the European Union requirements. Across the world, reporting on non-financial information is regulated by voluntary guidelines. The paper presents conclusions of a content analysis of annual food business reports in the Slovak Republic in the context of G4 (GRI) directives from social and environmental points of view as key elements in social responsibility reporting. Individual social and environmental aspects of the research are disclosed by an enterprise if the information in its annual report conforms to defined G4 activities (GRI). All the food enterprises operating in Slovakia that compiled annual reports for 2017 were included in the research. Therefore, 142 annual reports with economic activities in 26 subclasses in the food industry sector were selected. The results present a current and comprehensive (full) reporting overview of this industry in Slovakia and reveal several shortcomings in executive reporting. The analysis of the environmental information in the annual reports shows that food enterprises reporting on environmental protection mainly focus on waste, product services, wastewater, materials and energy, evidenced by information about ongoing monitoring of the environmental impacts of production. In the social category, the G4 (GRI) directive defines four main aspects: (i) labour relations and the environment, (ii) human rights, (iii) society and (iv) liability for products.
Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme
Authors: Kranjc Miha Koprivnikar , Novak Metka , Pestell Richard G. , Lah Tamara T. 
Published: November 2019

Abstract

Background
Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12 to 15 months after the diagnosis. This is mostly due to therapy resistant glioblastoma stem cells in addition to intertumour heterogeneity that is due to infiltration of a plethora of host cells. Besides endothelial cells, mesenchymal stem cells and their differentiated progenies, immune cells of various differentiation states, including monocytes, comprise resident, brain tumour microenvironment. There are compelling evidence for CCL5/CCR5 in the invasive and metastatic behaviour of many cancer types. CCR5, a G-protein coupled receptor, known to function as an essential co-receptor for HIV entry, is now known to participate in driving tumour heterogeneity, the formation of cancer stem cells and the promotion of cancer invasion and metastasis. Clinical trials have recently opened targeting CCR5 using a humanized monoclonal antibody (leronlimab) for metastatic triple negative breast cancer (TNBC) or a small molecule inhibitor (maraviroc) for metastatic colon cancer. There are important CCL5 and CCR5 structure and signalling mechanisms in glioblastoma. In addition, the CCL5/CCR5 axis directs infiltration and interactions with monocytes/macrophages and mesenchymal stem cells, comprising glioblastoma stem cell niches.

Conclusions
CCR5 is highly expressed in glioblastoma and is associated with poor prognosis of patients. CCL5/CCR5 is suggested to be an excellent new target for glioblastoma therapy. The molecular mechanisms, by which chemoattractant and receptor respond within the complex tissue microenvironment to promote cancer stem cells and tumour heterogeneity, should be considered in forthcoming studies.
Reacción en cadena de la polimerasa en tiempo real para el diagnóstico de tuberculosis pleural
Authors: Casallas-Rivera Martha Alejandra , Cardenas Bernal Ana María , Giraldo-Cadavid Luis Fernando , Prieto Diago Enrique , Santander Paola 
Published: November 2019

Introduction: The diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak.Objective: To establish the operating characteristics of real-time polymerase chain reaction (RT-PCR) hybridization probes for the diagnosis of pleural tuberculosis.Method: The validity of the RT-PCR hybridization probes was evaluated compared to a composite reference method by a cross-sectional study at the Hospital Universitario de la Samaritana. 40 adults with lymphocytic pleural effusion were included. Pleural tuberculosis was confirmed (in 9 patients) if the patient had at least one of three tests using the positive reference method: Ziehl-Neelsen or Mycobacterium tuberculosis culture in fluid or pleural tissue, or pleural biopsy with granulomas. Pleural tuberculosis was ruled out (in 31 patients) if all three tests were negative. The operating characteristics of the RT-PCR, using the Mid-P Exact Test, were determined using the OpenEpi 2.3 Software (2009).Results: The RT-PCR hybridization probes showed a sensitivity of 66.7% (95% CI: 33.2%-90.7%) and a specificity of 93.5% (95% CI: 80.3%-98.9%). The PPV was 75.0% (95% CI: 38.8%-95.6%) and a NPV of 90.6% (95% CI: 76.6%-97.6%). Two false positives were found for the test, one with pleural mesothelioma and the other with chronic pleuritis with mesothelial hyperplasia.Conclusions: The RT-PCR hybridization probes had good specificity and acceptable sensitivity, but a negative value cannot rule out pleural tuberculosis.