bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NTSC VLBI System and its application in UT1 measurement
Authors: Yao Dang , Wu Yuan-Wei , Zhang Bo , Sun Jing , Sun Yan , Xu Shuang-Jing , Liu Jia , Ma Lang-Ming , Gong Jian-Jun , Yang Ying , Yang Xu-Hai 
Published: June 2020

Abstract
In order to measure the Universal Time (UT1) in real time, National Time Service Center (NTSC) has built a VGOS-like (VLBI Global Observing System) broadband VLBI network, which includes three 13-m radio telescopes located in Jilin, Sanya and Kashi, and a data analysis center in Xi’an. Each station is equipped with a highly stable hydrogen atomic clock and a self-developed VLBI backend, and is colocated with two GPS receivers. This VGOS-like VLBI network may play an important role in improving the Chinese broadband VLBI technology and making valuable contributions to domestic VLBI measurements of UT1. In this paper, we introduce the specifications of this VLBI network, and present the UT1 measurements at C-band conducted in 2018 using the Jilin-Kashi baseline of this network. The comparisons between our UT1 estimates and those provided by IERS suggest that the NTSC VLBI network is capable to determine UT1 accurate at the level of 58.8 μs.
Identification of temperature anomaly RR Lyrae stars in LAMOST survey, misclassification and binarities
Authors: Li Lin-Jia , Qian Sheng-Bang , Zhang Jia , He Jia-Jia , Zhu Li-Ying 
Published: June 2020

Abstract
RR Lyrae stars, a well-known type of pulsating variable stars, have been known about for more than a century. A large amount of photometric data on RR Lyrae stars has been accumulated by space- and ground-based sky surveys, but the spectral data are relatively poor. Fortunately, the LAMOST sky survey project provides an opportunity to view them from the point of view of spectra. We collect the atmospheric parameters of 1685 RR Lyrae stars provided by the LAMOST catalog, and carry out research by using the reliable T
eff. We find that there is a clear correlation between their T
eff and pulsation periods, which is consistent with the pulsation and evolution theories of RR Lyrae stars. In addition, we focus on those RR Lyrae stars with abnormal temperatures. After analyzing the data from several photometric surveys, we find that some of these temperature anomalies are misclassified variable stars (e.g., eclipsing binaries, pulsating stars on main sequence), and some are RR Lyrae binary candidates. For the latter, the temperatures of potential companions should be lower and their luminosities should not be neglected (e.g., red giant stars). We obtain that the ratio of temperature anomaly stars to all the sample stars is 4%, which means that the impact on the further analysis (e.g., kinematics analysis) is low. We also present the catalogs of spectral anomaly RR Lyrae stars.
The temperature of IGM at high redshifts: shock heating and high mach problem
Authors: Jia Jun-Yi , Zhu Wei-Shan , Gao Liang , Feng Long-Long 
Published: June 2020

Abstract
The thermal history of cosmic gas in the dark ages remains largely unknown. It is important to quantify the impact of relevant physics on the IGM temperature between z = 10 and z ∼ 30, in order to interpret recent and oncoming observations, including results reported by EDGES. We revisit the gas heating due to structure formation shocks in this era, using a set of fixed grid cosmological hydrodynamical simulations performed by three different codes. In all our simulations, the cosmic gas is predicted to be in multiphase state since z > 30. The gas surrounding high density peaks gradually develops a relation more sharp than T ∝ ρ
2/3, approximately T ∝ ρ
2, from z = 30 to z = 11, might be due to shock heating. Meanwhile, the gas in void region tends to have a large local Mach number, and their thermal state varies significantly from code to code. In the redshift range 11 – 20, the mass fraction of gas shock heated above the CMB temperature in our simulations is larger than previous semi-analytical results by a factor of 2 to 8. At z = 15, the fraction varies from ∼ 19% to 52% among different codes. Between z = 11 and z = 20, the gas temperature

〈

1
/

T
K

〉

M

−
1

is predicted to be ∼ 10 – 20 K by two codes, much higher than the adiabatic cooling model and some previous works. However, in our simulations performed by RAMSES,

〈

1
/

T
K

〉

M

−
1

is predicted to be even below the temperature required to explain result of the EDGES. Given the fact that different codes give different predictions, currently, it seems a challenge to make solid prediction on the temperature of gas at z ∼ 17 in simulations.
Benchmarking near-term devices with quantum error correction
Authors: Wootton James R 
Published: June 2020

Abstract
Now that ever more sophisticated devices for quantum computing are being developed, we require ever more sophisticated benchmarks. This includes a need to determine how well these devices support the techniques required for quantum error correction. In this paper we introduce the topological_codes module of Qiskit-Ignis, which is designed to provide the tools necessary to perform such tests. Specifically, we use the RepetitionCode and GraphDecoder classes to run tests based on the repetition code and process the results. As an example, data from a 43 qubit code running on IBM’s Rochester device is presented.
Caplacizumab: an anti–von Willebrand factor antibody for the treatment of thrombotic thrombocytopenic purpura
Authors: Hollifield Alyssa L , Arnall Justin R , Moore Donald C 
Published: June 2020

Abstract

Purpose
The pharmacology, pharmacokinetics, efficacy, safety, dosing and administration, and place in therapy of caplacizumab, a novel antibody fragment that inhibits von Willebrand factor, for the treatment of acquired thrombotic thrombocytopenic purpura (TTP) are summarized.

Summary
Caplacizumab is a humanized anti–von Willebrand factor monoclonal antibody fragment that inhibits the interaction between ultralarge von Willebrand factor multimers and platelets. Caplacizumab is indicated for use in combination with standard-of-care modalities such as plasma exchange and immunosuppressive therapy for the treatment of adults with acquired TTP. By inhibiting von Willebrand factor, caplacizumab offers a new approach to the management of TTP by preventing the development of potentially life-threatening microvascular thrombosis that can occur in the disease process. In a randomized, placebo-controlled phase 3 trial, patients with acquired TTP treated with caplacizumab had more rapid platelet level normalization than placebo users; caplacizumab use also resulted in lower rates of disease recurrence and TTP-related death. The most common adverse events associated with caplacizumab use are bleeding-related events. In a phase 3 trial, serious bleeding-related adverse events were reported in 8 patients (11%) in the caplacizumab group and 1 patient (1%) in the placebo group. Caplacizumab is administered as an 11-mg intravenous loading dose 15 minutes prior to plasma exchange, followed by administration of 11 mg subcutaneously daily after plasma exchange. Once-daily caplacizumab administration can be continued for 30 days after the last plasma exchange. The medication and supplies for administration are provided as a single-use kit; patients should be trained on proper reconstitution and self-administration technique prior to the use of caplacizumab in the ambulatory setting.

Conclusion
Caplacizumab is a first-in-class von Willebrand factor inhibitor approved for the treatment of adults with acquired TTP.
Advancing from protein interactomes and gene co-expression networks towards multi-omics-based composite networks: approaches for predicting and extracting biological knowledge
Authors: Randhawa Vinay , Pathania Shivalika 
Published: June 2020

AbstractPrediction of biological interaction networks from single-omics data has been extensively implemented to understand various aspects of biological systems. However, more recently, there is a growing interest in integrating multi-omics datasets for the prediction of interactomes that provide a global view of biological systems with higher descriptive capability, as compared to single omics. In this review, we have discussed various computational approaches implemented to infer and analyze two of the most important and well studied interactomes: protein–protein interaction networks and gene co-expression networks. We have explicitly focused on recent methods and pipelines implemented to infer and extract biologically important information from these interactomes, starting from utilizing single-omics data and then progressing towards multi-omics data. Accordingly, recent examples and case studies are also briefly discussed. Overall, this review will provide a proper understanding of the latest developments in protein and gene network modelling and will also help in extracting practical knowledge from them.
ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease
Authors: Zhou Mingxia , He Jing , Shi Yingying , Liu Xiaoman , Luo Shangjian , Cheng Cheng , Ge Wensong , Qu Chunying , Du Peng , Chen Yingwei 
Published: June 2020

Abstract

Background and Aims
There is evidence for a disturbed necroptosis function in many inflammatory diseases, but its role in inflammatory bowel diseases [IBD] and the underlying mechanisms are unclear. Here, we studied the functional significance and molecular mechanisms of ABIN3, a ubiquitin-binding protein, in regulating the ubiquitination and activation of necroptosis in IBD.

Methods
The expression of necroptosis hallmarks and ABIN3 were assessed in inflamed samples of IBD patients, dextran sodium sulphate [DSS]-induced colitis models, and azoxymethane [AOM]/DSS models in mice. ABIN3 was overexpressed and silenced to explore its function in regulating necroptosis, inflammation, and intestinal barrier function. Immuoprecipitiation [IP] and co-IP assays were performed to investigate the cross-talk between ABIN3 and deubiquitinating enzyme A20, and the mechanisms of coordinating ubiquitination modification to regulate necroptosis.

Results
Excessive necroptosis is an important contributory factor towards the uncontrolled inflammation and intestinal barrier defects in IBD and experimental colitis. Blocking necroptosis by Nec-1s or GSK’872 significantly prevented cell death and alleviated DSS-induced colitis in vivo, whereas in the AOM/DSS model, necroptosis inhibitors aggravated the severity of colitis-associated colon carcinogenesis [CAC]. Mechanistically, ABIN3 is rapidly recruited to the TNF-RSC complex, which interacts and coordinates with deubiquitinating enzyme A20 to control the K63 deubiquitination modification and subsequent activation of the critical necroptosis kinase, RIPK3, to suppress necroptosis.

Conclusions
ABIN3 regulates inflammatory response and intestinal barrier function by interacting with A20 and coordinating the K63 deubiquitination modification of necroptosis in IBD.
Relationship of salt added during preparation and salt intake of cooks
Authors: Santos D , Lima J , Figueiredo JP , Rocha A 
Published: June 2020

Abstract
Introduction The excessive consumption of sodium is one of the main problems in public health and responsible for the loss of years of a healthy life. The salt added to the meals represents a large part of the salt ingested, and the collaborators/cooks responsible for its addition need careful analysis, and intervention adjusted to the analysed reality, its salt consumption and its perception of saltiness may influence the amount of salt added.
Objectives This study had as main objective to perceive the relationship between the perception of salt of the employees of the Food and Nutrition Unit and the amount of salt added in the meals that were confectioned.
Methodology An observational, analytical, cross-sectional study was conducted, in which 6 selected cooks from the IPSS’s of Águeda participated. In order to estimate the amount of salt added to the meals, 20 samples of meals prepared by the cooks were taken, and a quantitative assessment of average salt per meal was made using Flame Photometry. The cooks were also subjected to two taste sensitivity tests. The data treatment was performed using the statistical software SPSS, and a statistical significance level of 5% was considered.
Results A better perception of the salty taste was observed in the cooks of Institution B. Although there were no differences with statistical significance in the quantity of salt of the meals between the two institutions, the mean and maximum addition of salt in the cooked meals was higher in institution B, regardless of the cook evaluated.
Conclusion The perception of the salty taste of the cooks does not seem to determine the amount of salt added to the meals.
New perspectives for physiotherapy education concerning assistive technology solutions as valid options to enhance functioning and quality of life
Authors: Martins A C , Francisco P 
Published: June 2020

Abstract
Introduction Recognizing that AT service characteristics, including knowledge and reasoning of providers, play a potential role in the appropriated selection and training, with impact on the psychosocial domains of QoL. In Portugal, AT services are detected to be ineffective concerning evaluation, recommendation, advocacy, training and outcome measuring, what could be a reason for these findings.
Objectives To investigate the relationship between AT services characteristics and psychosocial impact of the wheelchairs on users QoL to get insights to new approach models in physiotherapy.
Methodology Procedures included answering to self-administered questionnaires at their own. The dependent variable was the psychosocial impact of assistive devices (PIADS) and the independent variables were satisfaction with AT (QUEST) and AT service characteristics.
Results Participants were 184 wheelchair users for more than one year with diverse diagnosis; age M = 37.3 years, recruited at physiotherapy/rehabilitation settings in Portugal. Wheelchair users are more satisfied with devices than with AT services. Correlations between psychosocial impact of wheelchair are moderate regarding the satisfaction of device dimension, measured by QUEST. No corrections were found to satisfaction with service dimension Manual wheelchair users scored lower psychosocial impact than motorized wheelchair users and that difference was statistically significant.
Conclusion PT should be aware of the newest high technology devices introduced on the market, payment sources and state AT programs as well as destigmatize dependence associated to AT. We got significant insights to AT field and to the development of PT curriculum; PT students need more than the basic level of knowledge and training they achieved at school to feel prepared to provide AT services. After graduation, PTs need continuing education on AT. Strategies are discussed on this report.
Relationship between lower limb asymmetries, impulsion and balance in senior football players
Authors: Domingues J , Castro M 
Published: June 2020

Abstract
Introduction Football is the most popular sport in the world and there are over 38 million players practicing it worldwide. In this sport, players usually have a prefered lower limb over other. This preference can lead to bilateral asymmetries and improve the risk of injury in the players. It is important to understand if asymmetries have an influence on athletes’ performance, on balance or impulsion.
Objectives The main objective of this study is to evaluate the bilateral and unilateral asymmetries related to the lower limb muscle strength of individuals who practice senior football, and relate them to eventual impulse and balance deficits.
Methodology 11 soccer players (age 21.91 ± 3.14 years; weight: 73.45 ± 7.59 Kg; height: 178.91 ± 8.02; BMI: 22.97 ± 2,12) were evaluated. The protocol defined in this study consisted of collecting data on maximum concentric torque at 60o/s, 180o/s and 300o/s in Biodex System 3. Both lower limbs were tested. Then the Y-balance test was performed on a force platform and the athletes’ flight time were recorded. We also calculated the bilateral deficit between the dominant lower limb and the non-dominant lower limb for the quadriceps and hamstrings and the hamstring/quadriceps (H/Q) ratio for each lower limb
Results There were no statistically significant differences between the maximum torque produced by the dominant lower limb and the maximum force torque produced by the dominant lower limb (p &lt; 0.05). The conventional I / Q ratio has values similar to those described in the literature. The relationship between bilateral asymmetry of lower limb strength, balance and impulsion was not statistically significant (p &gt; 0.05) at any angular velocity.
Conclusion There are no statistically significant differences between bilateral and unilateral asymmetries of lower limb strength, balance and impulsion.
Twelve-week multimodal programs can improve dual-task performance in risk factors for falls in community-dwelling older adults: a pilot study
Authors: Rosado H , Bravo J , Raimundo A , Mendes F , Pereira C 
Published: June 2020

Abstract
Introduction Performing a dual-task (DT), mainly while walking and performing another task simultaneously, is seen as determinants factors for falls and injuries in older adults. A psychomotor intervention relying on the prevention of sensorimotor and neurocognitive deterioration may prevent falls. The whole-body vibration (WBV) promotes the increase of agility, reducing the risk of falling. However, an intervention that combines both methods can lead to additional benefits, particularly as regards DT.
Objectives To evaluate the feasibility and the effect of two multimodal programs designed for community-dwelling older adults, fallers or at high risk of falling, on DT performance ability.
Methodology Thirty-seven participants (74.3±5.2 years) were randomly assigned into experimental group 1 [EG1] (psychomotor intervention); or experimental group 2 [EG2] (psychomotor intervention + WBV). DT performance (TUGcog) was assessed by the Timed Up and Go Test (s) performed simultaneously with the counting backward cognitive task.
Results Adherence rate was 86.3%. Wilcoxon test comparisons showed improvements from baseline to post-intervention on EG1 (time (s): 10.1±2.7 vs. 9.0±2.7, p = 0.001; cognitive stops (n): 0.9±1.0 vs. 0.2±0.4, p = 0.012; motor stops (n): 0.3±0.5 vs. 0.0±0.0, p = 0.025), corresponding to an effect size (cohen’s d) ranging from 0.41 (small) to 0.92 (medium) and on EG2 (time (s): 9.9±2.5 vs. 8.5±1.8, p = 0.010; cognitive stops (n): 1.1±0.7 vs. 0.4±0.5, p = 0.004), corresponding to a d ranging from 0.64 (medium) to 1.15 (medium). There were no significant differences between groups.
Conclusion These preliminary results suggested that the multimodal programs were feasible and effective in reducing the risk of falling by improving the determinant risk factor DT performance. Trial Registration: ClinicalTrials.gov Identifier: NCT03446352. Funding: This study was funded by ESACA Project (Grant ALT20-03-0145-FEDER-000007) and by FCT (SFRH/BD/147398/2019).
Prevalence of self-medication in adolescents
Authors: Almeida I , Rocha C , Balteiro J 
Published: June 2020

Abstract
Introduction Self-medication by definition is the use of over-the-counter medications, in which the patient or his / her caregiver decides which drug to use, in order to treat or relieve symptoms. Self-medication is considered one of the health risk behaviours found among adolescents.
Objectives The main objective of this study was to determine the prevalence of self-medication for adolescents enrolled in the 10th and 12th year of the High School/3 Dra Maria Cândida - Mira and the Lima-de-Faria High School – Cantanhede in the 2018/2019 school year.
Methodology A questionnaire was handled and processed with statistical program, version 24.0 SPSS. This study is based on the correlational descriptive type with cross cohort. The study took place on the school year of 2018/2019 and the data acquisition took place over the course of 2 months.
Results The sample comprised 421 adolescents, of whom 344 (81.7%) already tried self-medication in some way or form and 278 (66.0%) did that in the last 6 months. The main health problems that motivated self-medication were headache (62.5%), the flu (57.5%), sore throat (45.6%) and fever (44.4%). Analgesics/antipyretics were the most consumed drugs (71%) followed by non-steroidal anti-inflammatory drugs (66.0%). The Pharmacy (71.7%) was the preferred place to purchase drugs; however, 222 adolescents (52.7%) reported having medicines at home. Of the adolescents who resort to self-medication, 59.6% sought additional information or clarification of the drug, referring to the package leaflet as the main source (43.2%). Of these, 59.9% revealed that they are aware of the risks that the drugs taking may cause.
Conclusion It was observed that self-medication is very common in adolescents, making it important to carry out more studies in Portugal and its population, on this practice, due to studies scarcity. These data can be used to define strategies for the dissemination of the rational use of the drug in adolescent population.
Exergaming as a tool to enhance strength, balance, gait, mobility, participation, self-efficacy for exercise and adherence in older adults
Authors: Martins A C , Quatorze J , Guia D 
Published: June 2020

Abstract
Introduction It is projected that the number of adults aged 60 or above will be 1.4 billion in 2030 and 2.1 billion in 2050. With aging, mobility limitations can cause severe difficulties on being independent during activities of daily living. Exercise has been shown as effective to counteract the impact of aging, although it is hard to create adherence. Exergames, as they increase the appeal of exercise, show promising results in terms of participation and promotion of healthy behaviours.
Objectives This study aimed at assessing the effectiveness of the Otago Exercise Program incorporated in FallSensing Exergames.
Methodology Community-dwelling older adults aged 60 or over, were recruited from facilities in Coimbra, Portugal and randomized in two groups, 27 allocated to the intervention (IG) and 34 to the control (CG). Regular activities of daily living (CG) were compared to an Exergame program (IG). Assessments were made at baseline and re-assessments at 8 weeks/16 sessions, regarding strength, balance, walking speed, participation and self-efficacy for exercise.
Results 61 older adults (77% female), mean ages were 82.22 (IG) and 87.26 (CG) years. After 8 weeks, CG demonstrated a decrease in functional ability. IG got improvement in Step test (p = 0.001), 4 Stage Balance Modified test (p = 0.001), Self-Efficacy for Exercise (p = 0.009) and Activities and Participation Profile Related to Mobility (p &lt; 0.001) questionnaires.
Conclusion Exergaming was safe and effective in improving functional ability, participation and self-efficacy. Nevertheless, some considerations are necessary when prescribing an Exergames, mainly concerning frequency and intensity of the exercise program and participants’ age.