bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral breast reconstruction with the free contralateral split breast flap using supermicrosurgical anastomosis: A case report
Authors: Scaglioni Mario F. , Rodi Timo , Wishart Katarina , Fritsche Elmar 
Published: September 2020

AbstrctConsecutive or simultaneous contralateral breast reduction is a frequent request from patients undergoing unilateral breast reconstruction. Both procedures can be combined using otherwise discarded tissue as a split breast graft for reconstruction of the contralateral side. There have been few reports on the use of pedicled split breast grafts. We present a 75‐year‐old female with multicentric mammary carcinoma following chemotherapy, mastectomy, axillary lymph node dissection and radiotherapy. She requested a reconstruction of the left breast as well as reduction of the right breast. Risk factors, including heavy alcohol and tobacco dependence and COPD, limited the surgical options. While a free flap breast reconstruction was the standard feasible option, we opted for a procedure with minimal surgery‐related morbidity. The right breast was evidently tumor‐free, and the patient had no family history of breast cancer. Reconstruction was performed 22 months postmastectomy. The split‐breast free flap was based on the right internal mammary artery (IMA) perforator and harvested during the right‐sided breast reduction. Microsurgical anastomosis was performed on the IMA perforator on the left side. Mastopexy was performed on the right side and the nipple‐areola complex (NAC) was transferred to its new position as a free graft to complete the breast reduction. A tattoo of the left NAC was performed 4 months postreconstruction. There was complete flap survival with a pleasant cosmetic result. Split breast reconstruction could be an alternative to more common procedures. However, this approach is only feasible in patients with hypertrophic contralateral breast and absence of risk factors for developing a second primary breast cancer.
Compact wideband microstrip‐slotline bandpass filter with sharp selectivity and suppressed spurious harmonic
Authors: Chai Yongqiang , Cheng Chonghu , Shi Yanfeng , Qin Chanchan , Hu Shengbo 
Published: September 2020

AbstractA novel compact wideband microstrip‐slotline bandpass filter (BPF) with roll‐off cutoff slop and extended upper stopband is proposed, which consists of two cascaded microstrip‐to‐microstrip vertical transitions. Under the influence of interdigital capacitor, a pair of transmission zeros (TZs) at both sides of passband are generated to effectively enhance shirt selectivity, the mechanism of cross‐coupling structure is theoretically interpreted in detail based on equivalent transmission line network. In order to well suppress the upper stopband spurious harmonic, there are additional five TZs are introduced by properly adjusting the electrical length of open‐ended slotline sections and etching a set of spurlines on the feeding lines. For experimental validation, two broadband BPFs with/without spurlines are designed, fabricated, and measured. The measured results demonstrate that the BPF with spurlines have more excellent electric performances compared with the one without spurlines. The return loss ≥17.38 dB, insertion loss ≤0.82 dB with the 3‐dB fractional bandwidth (FBW) of 134.52%, the extended upper stopband is up to 3.86 times center frequency with rejection level better than 20.63 dB, the spurious harmonic is significantly suppressed without increasing additional circuit dimension, the compact effective circuit size is only 0.95λg*0.29λg, λg is guided wavelength at center frequency. Finally, the theoretical analysis is well verified by measured and simulated results, excellent agreement between them is achieved.
A 16‐element array fed with a switchable power divider
Authors: Chen Tsair‐Rong , Liu Ting‐Yan , Cheng Hao‐Yuan , Row Jeen‐Sheen 
Published: September 2020

AbstractA pattern reconfigurable design realized by a planar array integrated with a switchable feed network is presented. The array has 16 radiating elements, and each element is a printed dipole backed with a metallic box. These elements are divided into four groups, and the excitation state of each group can be controlled with the feed network. By varying the number of the active groups, the radiation pattern of the array is reconfigured. Simulated results demonstrate that the proposed array can generate broadside beams with a front‐to‐back ratio of higher than 25 dB, and the half‐power beamwidths of these main beams in E‐plane or H‐plane can be switched among 20°, 26°, and 46°; besides, the array can produce three different side lobe levels, including −1, −12, and − 25 dB, in the two principal planes. For the proposed pattern reconfigurable array, a prototype is constructed, and its experimental results are also exhibited to validate the simulated data.
Unsupervised learning for deformable registration of thoracic CT and cone‐beam CT based on multiscale features matching with spatially adaptive weighting
Authors: Duan Luwen , Ni Xinye , Liu Qi , Gong Lun , Yuan Gang , Li Ming , Yang Xiaodong , Fu Tianxiao , Zheng Jian 
Published: September 2020

PurposeCone‐beam computed tomography (CBCT) is a common on‐treatment imaging widely used in image‐guided radiotherapy. Fast and accurate registration between the on‐treatment CBCT and planning CT is significant for and precise adaptive radiotherapy treatment (ART). However, existing CT–CBCT registration methods, which are mostly affine or time‐consuming intensity‐ based deformation registration, still need further study due to the considerable CT–CBCT intensity discrepancy and the artifacts in low‐quality CBCT images. In this paper, we propose a deep learning‐based CT–CBCT registration model to promote rapid and accurate CT–CBCT registration for radiotherapy.MethodsThe proposed CT–CBCT registration model consists of a registration network and an innovative deep similarity metric network. The registration network is a novel fully convolution network adapted specially for patch‐wise CT–CBCT registration. The metric network, going beyond intensity, automatically evaluates the high‐dimensional attribute‐based dissimilarity between the registered CT and CBCT images. In addition, considering the artifacts in low‐quality CBCT images, we add spatial weighting (SW) block to adaptively attach more importance to those informative voxels while inhibit the interference of artifact regions. Such SW‐based metric network is expected to extract the most meaningful and discriminative deep features, and form a more reliable CT–CBCT similarity measure to train the registration network.ResultsWe evaluate the proposed method on clinical thoracic CBCT and CT dataset, and compare the registration results with some other common image similarity metrics and some state‐of‐the‐art registration algorithms. The proposed method provides the highest Structural Similarity index (86.17 ± 5.09), minimum Target Registration Error of landmarks (2.37 ± 0.32 mm), and the best DSC coefficient (78.71 ± 10.95) of tumor volumes. Moreover, our model also obtains comparable distance error of lung surfaces (1.75 ± 0.35 mm).ConclusionThe proposed model shows both efficiency and efficacy for reliable thoracic CT–CBCT registration, and can generate the matched CT and CBCT images within few seconds, which is of great significance to clinical radiotherapy.
Supramolecular gels of gluconamides derived from renewable resources: Antibacterial and anti‐biofilm applications
Authors: Siva Prasad Yadavali , Manikandan S. , Lalitha Krishnamoorthy , Sandeep Miryala , Vara Prasad R. , Arun Kumar R. , Srinandan C.S. , Uma Maheswari C. , Sridharan Vellaisamy , Nagarajan Subbiah 
Published: September 2020

AbstractCarbohydrates are versatile materials widely used for several applications including food, pharmaceuticals, cosmetics, and drug delivery systems due to their inherent properties such as non‐toxicity, biodegradability, and bio‐compatibility. Specifically, the urge on carbohydrate research is due to its significance in the biological system, for example, a glycoprotein found in the extracellular matrix, involved in signaling pathways, cell–cell interaction and cell–matrix interaction. Because of the increase in demand of glycolipids for biological applications, in this report, a set of three structurally related gluconamide‐based amphiphiles were synthesized from renewable resources, δ‐gluconolactone and cashew nut shell liquid. The molecular structure of the synthesized glycolipids was characterized by NMR and mass spectral techniques. Molecular self‐assembly of gluconamide‐based amphiphiles was investigated relative to the molecular structure and nature of the solvent used. Interestingly, the nature of the hydrophobic tail present in the glycolipids influences the self‐assembly pattern, which results in a hydrogel, organogel and highly insoluble nanorods. Gelation studies clearly revealed that the involvement of different magnitude of non‐covalent interactions such as hydrogen bonding, π–π stacking and van der Waals interaction. Morphology of self‐assembled architecture was investigated by optical microscopy, FESEM and FETEM analysis. The mechanism involved in the molecular self‐assembly has been deduced by small angle XRD analysis. Thermo reversibility and the thixotropic nature of the derived gels were identified by rheological measurements. Further, antimicrobial and biofilm inhibitory activity of gluconamide‐based amphiphiles were studied against various pathogenic bacterial strains Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium, and Pseudomonas aeruginosa, and found effective in inhibition of biofilm and possesses the antibacterial property. Altogether, gluconamide‐based amphiphiles reported in this paper could be potentially used for some of the human problems caused by bacterial biofilms such as infections in the intravascular catheter, burn‐wounds, chronic sinusitis and implanted medical devices.
Genetic variants and expression changes in urgency urinary incontinence: A systematic review
Authors: Post Wilke M. , Ruiz‐Zapata Alejandra M. , Grens Hilde , de Vries Rob B. M. , Poelmans Geert , Coenen Marieke J. H. , Janssen Dick A. W. , Heesakkers John P. F. A. , Oosterwijk Egbert , Kluivers Kirsten B. 
Published: September 2020

AbstractAimTo perform a systematic review summarizing the knowledge of genetic variants, gene, and protein expression changes in humans and animals associated with urgency urinary incontinence (UUI) and to provide an overview of the known molecular mechanisms related to UUI.MethodsA systematic search was performed on March 2, 2020, in PubMed, Embase, Web of Science, and the Cochrane library. Retrieved studies were screened for eligibility. The risk of bias was assessed using the ROBINS‐I (human) and SYRCLE (animal) tool. Data were presented in a structured manner and in the case of greater than five studies on a homogeneous outcome, a meta‐analysis was performed.ResultsAltogether, a total of 10,785 records were screened of which 37 studies met the inclusion criteria. Notably, 24/37 studies scored medium‐high to high on risk of bias, affecting the value of the included studies. The analysis of 70 unique genes and proteins and three genome‐wide association studies showed that specific signal transduction pathways and inflammation are associated with UUI. A meta‐analysis on the predictive value of urinary nerve growth factor (NGF) levels showed that increased urinary NGF levels correlate with UUI.ConclusionThe collective evidence showed the involvement of two molecular mechanisms (signal transduction and inflammation) and NGF in UUI, enhancing our understanding of the pathophysiology of UUI. Unfortunately, the risk of bias was medium‐high to high for most studies and the value of many observations remains unclear. Future studies should focus on elucidating how deficits in the two identified molecular mechanisms contribute to UUI and should avoid bias.
Targeted Therapy with Anlotinib for a Patient with an Oncogenic FGFR3-TACC3 Fusion and Recurrent Glioblastoma
Authors: Wang Yong , Liang Dandan , Chen Jimin , Chen Huan , Fan Rui , Gao Ye , Gao Yongsheng , Tao Rongjie , Zhang Henghui 
Published: September 2020

Abstract

We describe a case of recurrent glioblastoma treated with anlotinib in this report. The patient was administered anlotinib 12 mg p.o. once every day (days 1–14, with a 21-day cycle) (anlotinib clinical study NCT04004975) and oral temozolomide chemotherapy 100 mg/m2 (days 1–7, days 15–21, 28-day cycle; 12 cycles). After 2 months of therapy, the patient achieved a partial response that has been maintained for &gt;17 months of follow-up. Molecular characterization confirmed the presence of a TERT promoter mutation, wild-type IDH1/2, an FGFR3-TACC3 fusion, and FGFR3 amplification in the patient. Anlotinib is a multitarget tyrosine kinase inhibitor that was originally designed to inhibit VEGFR2/3, FGFR1–4, PDGFRα/β, and c-Kit. Patients with TERT promoter mutations and high-grade IDH-wild-type glioma have shorter overall survival than patients with IDH-wild-type glioma without TERT promoter mutations. However, this patient had a favorable clinic outcome, and FGFR3-TACC3 fusion may be a new marker for treatment of glioma with anlotinib.

Key Points
This case study is believed to be the first report that FGFR3-TACC3 fusion could be a novel indication to treat recurrent glioblastoma with the drug anlotinib. This case exhibited an exceptional response (maintained partial response &gt;17 months) after 2-month combined therapy of anlotinib and oral temozolomide chemotherapy. This case also underscores the importance of molecular diagnosis for clinically complex cases. Tumor tissue-based assessment of molecular biomarkers in brain tumors has been successfully translated into clinical application.
Fire‐retardant carbon/glass fabric‐reinforced epoxy sandwich composites for structural applications
Authors: Javaid Atif , Ashraf Hafiz Tanveer , Mustaghees Muhammad , Khalid Arslan 
Published: September 2020

AbstractIn this study, the fire‐retardant performance of lightweight sandwich composites, with modified epoxy impregnated carbon and glass fabric reinforcements and an aluminum honeycomb core, is investigated. The fire‐retardant performance of the fabricated sandwich composites is improved by treating carbon fiber reinforcements with phosphoric acid, and by impregnating the epoxy matrix with different loadings of ammonium polyphosphate (APP) fire‐retardant additive. The laboratory aging behavior of sandwich composites is also carried out to further investigate the degradation resistance of the panels under extreme conditions. Fire and mechanical properties of epoxy and sandwich panels are investigated using UL‐94, limiting oxygen index (LOI), thermal gravimetric analysis, compression tests, and three‐point bending tests. In the case of sandwich composites, a maximum of 1345 and 45.2 MPa flexural and compression modulus, respectively, are achieved with 10 wt% APP content in epoxy. Maximum 30% and 33% LOI values are achieved with 10% APP content in the epoxy and sandwich panels, respectively.
Motivational contagion during exercise and the role of interpersonal relationships: An experimental study
Authors: Boss Martin , Kleinert Jens 
Published: September 2020

AbstractThe present research focused on the phenomenon of motivational contagion while being physically active. It can be assumed that communication with significant others impacts upon a person's behavior in situations where communication or interaction is not explicitly intended to change behavior. Specifically, the purpose of the two present studies was to examine the effect of positive (i.e., intrinsically connoted) and negative (i.e., extrinsically connoted) self‐disclosure from a confederate on the motivational state of an individual simultaneously exercising with the confederate. These studies sought to replicate the experimental study of Scarapicchia, Andersen, & Bengoechea (2013). In addition, to test the further assumption that the relationship impacts upon contagion processes, we included a short team‐building intervention involving our confederate and the participant in order to manipulate the relationship quality (Study 1) and to compare friends with strangers (Study 2). Our results show that the participants who were exposed to the intrinsic cues (e.g., “I enjoy riding the bike, it's great that there is a study about it”) reported greater interest and enjoyment while exercising on the bicycle ergometer than those who were exposed to extrinsic cues (e.g., “I don't enjoy cycling at all. I'm only participating because my teacher told me to do so”). The relationship between the confederate and participant was not found to affect the main effect.
Use of telehealth platforms for delivering supportive care to adults with primary brain tumors and their family caregivers: A systematic review
Authors: Ownsworth Tamara , Chan Raymond J. , Jones Stephanie , Robertson Julia , Pinkham Mark B. 
Published: September 2020

AbstractObjectiveTelehealth platforms have potential utility for providing remote access to supportive care to people with brain tumour. This systematic review aimed to evaluate the feasibility, acceptability and efficacy of delivering supportive care via telehealth platforms to adults with primary brain tumour and family caregivers.MethodsA systematic search of PsycINFO, MEDLINE, CINAHL, Embase, Scopus and Cochrane Library was conducted from 1980 to 1st June 2020 to identify eligible studies. Methodological quality was assessed by two independent reviewers.ResultsSeventeen articles, reporting on 16 studies, evaluated telephone‐based support (5 studies), videoconferencing (3 studies), web‐based programs and resources (7 studies) or combined use of videoconferencing and web‐based modules (1 study) to deliver supportive care remotely. Caregivers were involved in 31% of interventions. Mean rates of accrual (68%) and adherence (74%) were moderate, whereas acceptability or satisfaction for those completing the interventions was typically high (M satisfied or very satisfied = 81%). Adherence rates were generally higher and clinical gains were more evident for interventions involving real‐time interaction as opposed to self‐guided interventions.ConclusionsTelehealth delivery of supportive care is feasible and acceptable to a high proportion of individuals with primary brain tumour and their caregivers. It is recommended that future research focuses on implementation outcomes, including factors influencing the uptake and sustainability of telehealth platforms in practice.
Developing a decision‐making framework for insect pest management: a case study using Aphis glycines (Hemiptera: Aphididae)
Authors: Dean Ashley N , Niemi Jarad B , Tyndall John C , Hodgson Erin W , O'Neal Matthew E 
Published: September 2020

AbstractBACKGROUNDThe profitability of farming varies based on factors such as a crop's market value, input costs and occurrence of resistant pests, all capable of altering the value of pest management tactics in an integrated pest management program. We provide a framework for calculating expected yield and expected net revenue of pest management scenarios, using the soybean aphid (Aphis glycines) as a case study. Foliar insecticide and host‐plant resistance are effective management tactics for preventing yield loss from soybean aphid outbreaks; however, pyrethroid‐resistant aphid populations pose a management challenge for farmers. We evaluated eight scenarios relevant to soybean aphid management in Iowa with varying probabilities of aphid outbreaks and insecticide‐resistant aphids occurring.RESULTSOur equation suggests that insecticide use is profitable when the probability of an aphid outbreak is ≥29%, and soybean production will become more costly with increasing probability of pyrethroid‐resistant aphids. If farmers continue to use pyrethroids, they will not experience financial consequences from pyrethroid‐resistant aphids until the chance of insecticide resistance is 48%. Aphid‐resistant varieties provided consistent yield and offered the highest net revenue under all conditions.CONCLUSIONThis framework can be used for other crop–pest systems to evaluate the profitability of management tactics and investigate how resistance impacts revenue for farmers. Including the cost of resistance in crop budgets can help farmers and agronomic consultants comprehend these impacts and enhance decision‐making to increase revenue and curb resistance development.
Spray drift mitigation using opposing synchronized air‐blast sprayers
Authors: Van Steenwyk Robert A , Siegel Joel P , Bisabri Barat , Cabuslay Christian S , Choi Jaimie M , Steggall J W , Mace Kevi C , Blecker Steve W , Poe Perry A , Peters‐Collaer Stephen R , Klassen Parry 
Published: September 2020

AbstractBACKGROUNDPesticide drift is a serious environmental and safety concern that affects all of US agriculture. A number of mitigation techniques to reduce pesticide drift have been recommended by industry, academic and government agencies. These techniques are very costly or reduce the efficacy of the pest control product and have not been implemented by US agriculture.RESULTSWhen using a novel spray technique (Air‐in), pesticide drift was significantly reduced by between 53% and 99% at 7.6 m from the orchard drip line when compared to the grower standard. This technique not only reduced pesticide drift, but also maintained or improved the amount of pesticide residue deposited (by 0.7–2.6‐fold) and the percentage pesticide coverage (by 1.0–1.4‐fold) with different air‐blast speed sprayers on almond, walnut and pistachio.CONCLUSIONThe Air‐in technique shows great promise in reducing pesticide drift while maintaining or improving pesticide coverage with minimal cost to the grower.
An adaptive EWMA control chart for monitoring the process mean in Bayesian theory under different loss functions
Authors: Noor‐ul‐Amin Muhammad , Noor Surria 
Published: September 2020

AbstractThe Shewhart control chart is used for detecting the large shift and an exponentially weighted moving average (EWMA) control chart is used for detecting the small/moderate shift in the process mean. A scheme that combines both the Shewhart control chart and the EWMA control chart in a smooth way is called the adaptive EWMA (AEWMA) control chart. In this paper, we proposed a new AEWMA control chart for monitoring the process mean in Bayesian theory under different loss functions (LFs). We used informative (conjugate prior) under two different LFs: (1) squared error loss function and (2) linex loss function for posterior and posterior predictive distributions. We used the average run length and standard deviation of run length to measure the performance of the AEWMA control chart in the Bayesian theory. A comparative study is conducted for comparing the proposed AEWMA control chart in Bayesian theory with the existing Bayesian EWMA control chart. We conducted a Monte Carlo simulation study to evaluate the proposed AEWMA control chart. For the implementation purposes, we presented a real‐data example.