bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE TRICKING OF ADVERTISERS (CRITICAL PRAGMATIC ANALYSIS)
Authors: Silalahi Tomson Sabungan 
Published: January 2020

ABSTRACT
Advertisements have their ideologies, values and particular interests existing in them and that must be viewed critically. Using critical pragmatic analysis, this article aims to unravel critically the ideologies, values and interests that advertisers want to convey through the discourse they conceal. To dismantle it, we will take such steps; (1) transcribing data from spoken language into written language, (2) noting how the overall narrative of the visual organization and the text in the advertisement; (3) examines imagery to be built by the advertiser, how the advertiser's imaging process is represented, who is omitted/ignored by the advertisement, what is ignored or absent in the advertisement, and last (4) the establishment of a text link; assessment, representation, relationships, identification. The results were obtained as follows; Ramayana Department Store (RDS) wants to change the mindset of its audience about the word “cool”. Implicitly viewers are forced to become more consumptive. If it should be likened to film, then advertiser act as protagonist, parents as antagonist and children as object which is oppressed.
Keywords: Ramayana Department Store, critical pragmatics, advertisement
TEACHING PERSUASIVE TEXTS THROUGH THINK-TALK-WRITE (TTW) STRATEGY: AN INSTRUCTIONAL ANALYSIS
Authors: Cahyani Isah 
Published: January 2020

Abstract
This research was conducted after noticing the writing problems occurred in grade VIII of one public junior high school in Bandung in academic year 2017/2018. The students showed their inability of writing persuasive texts in accordance with the generic structures and language uses. The treatment used to overcome the problem was think-talk-write (TTW) together with the application of video as the instructional media. The research foci were: 1) how the learning session with TTW strategy was planned and was conducted; 2) how the improvement of students’ learning outcome by using TTW with video media was; 3) how the students’ responses towards the use of TTW with video media were. The research aimed at equipping the students with the ability to write persuasive texts appropriately. The method employed was classroom action research conducted in three cycles. The data collection techniques used were tests, observations, and questionnaires. The data were analyzed through several steps: categorizing, interpreting and validating data. The result indicated that learning to write persuasive texts by using TTW with video media improved the students’ writing ability. This was pointed by the test result from all cycles; in cycle I, the mean of students’ scores was 63; in cycle II, it increased to be 72; and in cycle III, it showed improvement to be 81. To conclude, it was proved that TTW strategy could improve the students’ writing ability on persuasive texts.

Keywords: writing, persuasive texts, learning strategy, instructional media
Gestión del cambio: minimizando la resistencia a un proyecto de Centro de Servicios Compartidos en América Latina
Authors: Di Petta Arnaldo , Nogueira Ferraz Renato Ribeiro 
Published: January 2020

Rev.esc.adm.neg
Este trabajo presenta la gestión del cambio como la herramienta que permitió minimizar la resistencia de los empleados del área de finanzas de una multinacional a la implementación de un Centro de Servicios Compartidos (CSC) en América Latina. Los líderes y sus respectivos equipos en dieciséis países de la región se encontraban inmersos en el proceso de migración de transacciones financieras a un CSC subcontratado. El desafío fue facilitar la implementación de este proyecto minimizando los riesgos de no alcanzar el éxito y para eso se aplicó el método de Action-Research. Luego de analizar los tipos de resistencia a superar, el equipo desarrolló un plan de gestión del cambio para obtener el apoyo y el compromiso de los líderes, involucrando a los empleados para retener el conocimiento sin afectar los plazos de implementación del proyecto. Tratando de manera transparente, abierta y franca a todos los empleados directamente involucrados, se logró el compromiso individual de la mayoría, lo que contribuyó al éxito del proyecto. Por lo tanto, fue posible para el equipo identificar y tratar adecuadamente muchos riesgos que, de no resolverse adecuadamente, podrían haber retrasado la implementación del proyecto o incluso poner en peligro las actividades en las diferentes unidades de negocios de la multinacional en América Latina. La ejecución trató la resistencia, empoderó a los líderes locales como agentes de cambio, aclaró las dudas de los empleados y aseguró el cierre del proyecto a tiempo, dentro de las condiciones planificadas y sin afectar el negocio.
Choreographing life-experiences of balance control in people with Parkinson’s disease
Authors: LaGrone Sofie , Joseph Conran , Johansson Hanna , Enberg Birgit , Franzén Erika 
Published: January 2020

AbstractBackground Parkinson’s disease (PD) is a devastating neurodegenerative disorder. Reduced balance is one of the cardinal symptoms of PD, predisposing people living with PD to experience difficulties with the execution of tasks and activities, as well as hindering their involvement in meaningful life areas. The overarching aim of this study was to explore how deficits in balance control manifest in everyday life and how it is managed by people with PD (PwPD). Methods Qualitative description was used as methodology, and in-depth interviews were conducted with 18 participants, between the ages of 46 to 83 years, with mild to severe PD. Interview transcripts were analyzed using qualitative content analysis, following an inductive approach. Results One theme emerged from the analysis: Increased planning—choreographing life. Within this overarching theme, two categories were identified, namely Limitations in mobility and New restricted functioning in everyday life, each with 3-4 sub-categories. The categories described how PwPD handled decreased balance control in their everyday life by using motor and cognitive strategies as a consequence of not trusting their body’s capacity to control balance. Activities in everyday life, as well as the ability to partake in leisure and social activities were profoundly affected. Conclusion People with mild to severe PD used strategies to handle decreased balance and they choreographed their lives around their individual current state of mobility and balance. The knowledge gained from this study can be used to develop targeted interventions addressing the nuances of balance deficits in everyday life.
Comparison of relationships among French adult siblings with or without schizophrenia using the ASRQ-S: mediating effect on emotional distress
Authors: Plessis Léa , Wilquin Hélène , Pavani Jean-Baptiste , Bouteyre Evelyne 
Published: January 2020

Abstract

Background : Good sibling relationships in adulthood are known to be a protective factor for mental health. The present study examined and compared the relationships of siblings with either a healthy brother or sister or one experiencing schizophrenia. Methods : In the first phase, we ran a statistical comparison of the two sibling groups on the quality of their sibling relationships (warmth, conflict, and rivalry), emotional distress, and self-esteem. In the second phase, we looked at whether the quality of the sibling relationship modifies the impact of having a brother or sister with schizophrenia on emotional distress and self-esteem. Results : Results showed that sibling relationships in schizophrenia are less warm and are characterized by heightened rivalry and conflict. In addition, analysis revealed a mediating effect of sibling relationship on the emotional distress of siblings with a brother/sister diagnosed with schizophrenia. Conclusion : More needs to be done to enhance the mental health of adults who have a brother or sister with schizophrenia, notably via their sibling relationships.
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains
Authors: Li Shengjia , Ouyang Jinming , Zhao Bin , An Minghui , Wang Lin , Ding Haibo , Zhang Min , Han Xiaoxu 
Published: January 2020

Abstract
Background The rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment. We aimed to explore the temporal association of S68G and K65R mutations and disclose the role of the former on susceptibility to nucleotide/nucleoside reverse transcriptase inhibitor (NRTI) and viral replication with the K65R double mutations among CRF01_AE-infected patients who failed treatment. Methods The occurrence of S68G and K65R mutations was evaluated among HIV-1 of various subtypes in the global HIV Drug Resistance Database. The temporal association of S68G and K65R mutations was analyzed through next-generation sequencing in four CRF01_AE-infected patients who failed treatment with tenofovir/lamivudine/efavirenz. The impact of the S68G mutation on susceptibility to NRTI and replication fitness was analyzed using pseudovirus phenotypic resistance assays and growth competition assays, respectively. Results The frequency of the S68G mutation increased by 1.4–9.7% in almost all HIV subtypes and circulating recombinant forms in treatment-experienced patients, except subtype F. The S68G mutation often occurred in conjunction with the K65R mutation among RTI-treated patients, with frequencies ranging 21.1%–61.7% in various subtypes. Next-generation sequencing revealed that the S68G mutation occurred following the K65R mutation in three of the four CRF01_AE-infected patients. In these three patients, there was no significant change detected in the half maximal inhibitory concentration for zidovudine, tenofovir, or lamivudine between the K65R and K65R/S68G mutations, as demonstrated by the phenotypic resistance assays. Virus stocks of the K65R and K65R/S68G mutations were mixed with 4:6, 1:1, and 9:1 and cultured for 13 days, the K65R/S68G mutants outgrew those of the K65R mutants irrespective of the input ratio. Conclusions S68G may be a natural polymorphism and compensatory mutation of K65R selected by NRTIs in the CRF01_AE strain of HIV-1. This mutation does not affect susceptibility to NRTI; however, it improves the replication fitness of K65R mutants. This study deciphers the role of the S68G mutation in the HIV reverse transcriptase of the CRF01_AE strain and provides new evidence for the interpretation of drug-resistant mutations in non-B subtypes of HIV-1.
Genome-wide identification of diacylglycerol acyltransferases (DGAT) family genes influencing milk production traits in buffalo
Authors: Liu Jiajia , Wang Zhiquan , Li Jun , Li Hui , Yang Liguo 
Published: January 2020

Abstract
Background: The diacylglycerol acyltransferases (DGAT) are a vital group of enzymes in catalyzing triacylglycerol biosynthesis. DGAT genes like DGAT1 and DGAT2 , have been identified as two functional candidate genes affecting milk production traits, especially for fat content in milk. Buffalo milk is famous for its excellent quality, which is rich in fat and protein content. Therefore, this study aimed to characterize DGAT family genes in buffalo and to find candidate markers or DGAT genes influencing lactation performance.
Results: We performed a genome-wide study and identified eight DGAT genes in buffalo. All the DGAT genes classified into two distinct clades (DGAT1 and DGAT2 subfamily) based on their phylogenetic relationships and structural features. Chromosome localization displayed eight buffalo DGAT genes distributed on five chromosomes. Collinearity analysis revealed that the DGAT family genes were extensive homologous between buffalo and cattle. Afterward, we discovered genetic variants loci within the genomic regions that DGAT genes located in buffalo. Seven haplotype blocks were constructed and were associated with buffalo milk production traits. Single marker association analyses revealed four most significant single nucleotide polymorphisms (SNPs) mainly affecting milk protein percentage or milk fat yield in buffalo. Genes functional analysis indicated that these DGAT family genes could influence lactation performance in the mammal through regulating lipid metabolism.
Conclusion: In the present study, we performed a comprehensive analysis for the DGAT family genes in buffalo, which including identification, structural characterization, phylogenetic classification, chromosomal distribution, collinearity analysis, association analysis, and functional analysis. These findings provide useful information for an in-depth study to determine the role of DGAT family gens play in the regulation of milk production and milk quality improvement in buffalo.
Single-centre clinical follow-up of cladribine-treated patients from phase 2 and 3 trials
Authors: Moccia Marcello , Lanzillo Roberta , Petruzzo Martina , Nozzolillo Agostino , Angelis Marcello De , Carotenuto Antonio , Palladino Raffaele , Morra Vincenzo Brescia 
Published: January 2020

Abstract
The authors have requested removal of this preprint.
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis
Authors: Sharifi Roohollah , Jahedi Sajjad , Mozaffari Hamid Reza , Imani Mohammad Moslem , Sadeghi Masuod , Golshah Amin , Moradpoor Hedaiat , Safaei Mohsen 
Published: January 2020

Abstract
Background This meta-analysis evaluated the association of LTF , ENAM , and AMELX polymorphisms with dental caries susceptibility. Methods We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software. Results A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF , 11 ENAM , and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group. Conclusions The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.
A comparison of clinical outcomes between percutaneous endoscopic laminectomy decompression and traditional laminectomy decompression in Thoracic Ossification of Ligamentum Flavum with CT classification of type unilateral segments.
Authors: Wu Hui , Huang Wenzhou , He Dingwen , Deng Jianjian , Ye Jing , Cheng Xigao 
Published: January 2020

Abstract
Background: The aim of this study was to compare the effectiveness and safety of percutaneous endoscopic laminectomy decompression and traditional laminectomy decompression in the treatment of Thoracic Ossification of Ligamentum Flavum (T-OLF) with CT classification of type unilateral segments. Methods: We executed a retrospective study on 24 cases of T-OLF with CT classification of type unilateral segments between May 2015 and January 2018. All the patients were divided into two groups based on the relation to surgical methods. Patients in group A underwent percutaneous endoscopic laminectomy, and in group B underwent traditional laminectomy. According to the selection criteria, there were 10 patients in group A and 14 patients in group B. We mainly analyzed and compared the clinical, radiologic, perioperative outcomes, and surgery-related complications of the two groups of data. Results: Both groups improved significantly in the following projects：the JOA scores, mean JOA recovery rate, leg pain and radiologic results of decompression. However, no significant difference was found between the two groups. One case occurred dural tear in the early phase of percutaneous endoscopic laminectomy group. One patient occurred dural tear in during removal of OLF adhered to the dura mater in traditional laminectomy group. There were no cases of failure or recurrence in both groups. The percutaneous endoscopic laminectomy group have significant advantages in the following areas: back pain recovery, blood loss, hospital stay, hospitalization expenses and return-to-work. No post-laminectomy kyphosis was observed in any patients. Conclusions: Although percutaneous endoscopic laminectomy in thoracic region has a steep learning curve, percutaneous endoscopic laminectomy seemed to be an alternative surgical for T-OLF, type unilateral segments.
The evaluation of the distance between popliteus tendon or LCL footprint and the implant of the TKA using 3D template.
Authors: Takubo Akihito , Ryu Keinosuke , Iriuchishima Takanori , Nagaoka Masahiro , Tokuhashi Yasuaki , Aizawa Shin 
Published: January 2020

Abstract
Background When the surgeons perform total knee arthroplasty (TKA), PT and LCL iatrogenic injury are worried because those femoral footprints are relatively close to the bone resection lesion. The purpose of this study was to evaluate the distance between PT or LCL footprint and TKA implant using the three-dimensional (3D) template system.Methods Eighteen non-paired formalin fixed cadaveric lower limbs were used. All the surrounded soft tissue except the PT and knee ligaments were removed from the limb. Careful dissection of the PT and LCL was performed, and those femoral footprints were detected. Each footprint was periphery marked with a K-wire. CT scanning of the whole lower limb was then performed. The CT data was analyzed with 3D template system. Simulated models of TKA were Journey II BCS and Persona PS. The area of each footprint, and the length between most distal or posterior point of femur and the edge of each footprint were measured. When the implant model was matched to the CT image, the shortest length between each footprint and the bone resection were evaluated.Results The area of PT and LCL footprint were, 38.7±17.7mm 2 , and 58±24.6mm 2 , respectively. The length between most distal or posterior point of femur and the edge of the PT footprint were 10.3±2.4mm, and 14.2±2.8mm, respectively. The length between most distal or posterior point of femur and the edge of the LCL footprint were 16.3±2.3mm, and 15.5±3.3mm, respectively. When simulated the TKA, the shortest length between PT footprint and bone resection lesion of Journey II BCS and Persona PS were, 4.3±2.5mm, and 3.2±2.9mm, respectively. The shortest length between PT footprint and bone resection lesion of Journey II BCS and Persona PS were, 7.2±2.3mm, and 5.6±2.1mm, respectively. PT footprint was suffered by the bone resection of Journey II BCS TKA in 3 knees, and also by the Persona PS’s bone resection in 9 knees.Conclusion The PT and LCL femoral footprint existed close to the femoral bone resection lesion of the TKA. Careful attention is needed not to injure the PT and LCL in the surgical procedures.
Exclusive breastfeeding knowledge and practices among health care workers in northern Tanzania.
Authors: Mgongo Melina , Mlay Bertha , Damian Damian Jeremia , Amour Caroline , Leyaro Beatrice John , Msuya Sia Emmanuel 
Published: January 2020

Abstract
Background Exclusive breastfeeding (EBF) practice is one of the interventions improving child survival. Health workers have been shown to be vital in influencing EBF practices. Objectives To assess the level of knowledge and supportive practices on EBF among healthcare workers Kilimanjaro region, northern Tanzania. Methods A cross sectional study was conducted between April - June 2011 health care providers working in 36 randomly selected health facilities of Hai and Siha districts. A questionnaire was used to obtain information. Observation of health worker-client interaction was conducted using a check list. Results A total of 250 health workers participated in this study. The majority (80%) had adequate knowledge of EBF. However, 36% of providers believed light porridge should be introduced after 4 months and 43% believed infants will feel thirsty on breast- milk alone. Only 7% of providers answered correctly on skills of support, positioning and attachment. Fifty percent of the facilities with labour/maternity wards gave breastfeeding lessons to post delivery women. The majority (90%) gave theoretical information, without practical demonstration with positioning and/or attachment of the baby to the breast. Conclusion Providers had adequate theoretical knowledge of EBF but lacked important skills to support women in breastfeeding practices. Few labor/maternity facilities used the opportunity to educate women on EBF. Pre- and in-service health providers’ training on breastfeeding should target improved practical skills.
Downregulation of ALDH5A1 Promotes Tumor Metastasis and Contributes to Poor Prognosis in Ovarian Cancer
Authors: Cao Chen , Wang Xin , Li Rui , Jin Ping , Chen Hongwei , Xia Meng , Zhang Qinghua , Tian Xun 
Published: January 2020

Abstract
Background Despite modern therapies, ovarian cancer (OC) remains a major clinical problem with a high risk of mortality. We previously reported that low expression of ALDH5A1 could serve as an indicator for predicting poor prognosis in OC. However, the function of ALDH5A1 in OC progression has not been elucidated yet. Methods We firstly compared ALDH5A1 expression in metastatic tissues to primary site of OC based on the Oncomine database. Then wound healing assay and Transwell assay were utilized to determine the biological role of OC cells transfected with ALDH5A1 siRNA. To unravel the potential mechanism of ALDH5A1 meditating metastasis of OC, the co-expression profile of ALDH5A1 in OC cell lines and OC patients were generated using cBioPortal. Moreover, qRT-PCR and WB analysis were used to detect the expression levels of metastasis-related genes after ALDH5A1 suppression, HPA database was used to confirm the relative expression of ALDH5A1 and MMP in OC patients. In addition, KM survival plots in 578 OC patients from the TCGA database were analyzed. Results We proved lower ALDH5A1 expression in metastatic tissues compared to primary site of OC, and knockdown of ALDH5A1 promoted the malignant behavior of OC cells. Additionally, the co-expression profile of ALDH5A1 was significantly enriched in extracellular matrix (ECM) organization pathway. We further confirmed ALDH5A1 was negatively associated with MMP expression in OC, indicating that ALDH5A1 was closely related to OC metastasis via ECM organization pathway. Finally, KM survival plots revealed that low ALDH5A1 expression contributed to poor OC survival. Conclusions These results suggested a key role of ALDH5A1 in driving the progression of OC and identified ALDH5A1 as a robust therapeutic target of OC.