bluuebunny/crossref_metadata_2025_split huggingface dataset:
We Need to Talk About the Dog! Explorations of Human–Canine Relations and Community Hybridity in Bolivia
Authors: Bolton Maggie 
Published: April 2020

ResumenEn los estudios académicos de la región de los Andes el “giro animal” no ha sido un tema prominente en la antropología o la etnografía multiespecie. Hasta la fecha, los estudios andinos sobre las relaciones entre humanos y animales se han enfocado principalmente en el pastoreo de camélidos. Este artículo aborda una brecha en la literatura a través de un estudio etnográfico de la dinámica entre humano y perro en una comunidad de pastoreo de llamas en el sur de Bolivia y una descripción histórica de la presencia de los perros en la sociedad andina. Sigo el llamado de Dominique Lestel a estudiar a las comunidades híbridas a través de la etno‐etología y la eto‐etnología. Esta aproximación a los perros andinos desde una perspectiva de multiespecie revela el entrelazamiento de humanos y perros: cómo los humanos y los perros “se unen”, en la terminología de Donna Haraway, en actividades conjuntas, en particular viajes, en los que los perros son compañeros de trabajo esenciales de los humanos. Sin embargo, un examen ontológico del estado de los caninos revela sus ambigüedades. Son ajenos al entramado de entidades que comprende el ayllu, la unidad de organización social humana de los Andes que es inseparable del lugar y abarca características del paisaje y de los humanos. Los intrusos, como los suegros, son importantes para el ayllu por su definición y continuidad y, a este respecto, a los perros se les atribuye un papel específico como guías de las almas humanas en sus viajes al otro mundo. El análisis del material histórico refuerza las ambigüedades que rodean a los caninos, revelando que el perro es un agregado resultante de los encuentros coloniales. [especies compañeras, relaciones humano‐animal, comunidades híbridas, giro ontológico, etnografía multiespecie]
Skin surface lipidomics revealed the correlation between lipidomic profile and grade in adolescent acne
Authors: Zhou Mingyue , Yang Manli , Zheng Yumei , Dong Kun , Song Liya , He Congfen , Liu Wei , Wang Yiyu , Jia Yan 
Published: April 2020

AbstractBackgroundAcne is a multifactorial skin disorder frequently observed during adolescence with different grades of severity. The crucial factors of acne are the increase of lipids secretion and the change of composition on the skin surface lipid (SSL). However, there are no studies on the changes of lipid composition and content between different grades of adolescent acne in lesional skin and nonlesionsal skin.AimsThis study was to investigate correlation in the composition of SSL and different grades in order to understand the tendency of SSL alterations in this disease for successful acne management and prevention.MethodsA powerful analytical technique, UPLC‐QTOF‐MS, and multivariate data analysis were used to investigate SSL variations of lipid main classes, subclasses, and species.ResultsThe results indicated that sphinganine, triradylglycerols (TG), and phytosphingosine were important in adolescent acne development. The average fatty acids (FAs) chain length in patients with acne showed significantly shortened trend from mild to moderate adolescent acne. Additionally, the relative average content of TG, diglyceride (DG), FA, ceramides (Cers), and the level of unsaturated FAs significantly increased from mild to moderate adolescent acne. Interestingly, our results demonstrated that the phytosphingosine and sphinganine showed an increasing trend in mild acne groups, but decreasing trend in lesional skin of moderate group.ConclusionsLipidomics analysis suggested that the variation of TG, phytosphingosine, and sphinganine was closely related to the occurrence severity of acne in adolescent.
Twelve‐month prospective study of polymethylmethacrylate/collagen dermal filler for volume loss of the dorsal of hands
Authors: Yeh Lindsey C. , Goldberg David J. 
Published: April 2020

AbstractBackgroundDermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12 months.MethodsIn a 12‐month prospective study, 15 subjects were treated with PMMA filler in the bilateral dorsal hands. PMMA was injected 4 weeks after an initial screening visit, and touch‐up treatments were provided if needed 4 weeks later. Effectiveness was assessed by the provider using the validated Merz Hand Grading Scale (MHGS) and the Global Aesthetic Improvement Scale (GAIS). Subjects completed the Subject GAIS and the Subject Satisfaction Survey.ResultsAll subjects had at least 1 point of improvement on the MHGS starting from 1 month to 12 months after treatment. 75% of subjects had a 2‐point improvement at 12 months. Investigators reported that 92% of subjects had some degree of improvement at 12 months, while 75% of subjects self‐reported some degree of improvement. Approximately 75% of the subjects reported that they were satisfied with the treatment. Adverse events were minor and limited to swelling.ConclusionPMMA is a safe and effective treatment for volumizing the dorsal hands with improvement that is sustained for up to 12 months.
Faith and Agency: The Relationships Between Sense of Control, Socioeconomic Status, and Beliefs About God
Authors: LIU YINGLING , FROESE PAUL 
Published: April 2020

AbstractAn individual's sense of control varies with religiosity, but the direction of this relationship can change based on one's social status and one's image of God. Using data from the Baylor Religion Survey Wave V, our current study investigates how secure attachment to God, belief in a judgmental God, and belief in divine control are associated with sense of control. Our findings indicate that the type of religious belief explains when religion is positively or negatively related to the believers’ sense of control. And secure attachment to God and belief in divine control will compensate for social and economic deprivation. Still, belief in a judgmental God is negatively related to agency for believers across the stratification hierarchy. This indicates that a traditional fire‐and‐brimstone God is related to a lower sense of control, while more contemporary and individualized beliefs about God are connected to greater agency, especially for believers in need.
MRG1/2 histone methylation readers and HD2C histone deacetylase associate in repression of the florigen gene FT to set a proper flowering time in response to day‐length changes
Authors: Guo Zhihao , Li Zepeng , Liu Yuhao , An Zengxuan , Peng Maolin , Shen Wen‐Hui , Dong Aiwu , Yu Yu 
Published: April 2020

Summary

Day‐length changes represent an important cue for modulating flowering time. In Arabidopsis, the expression of the florigen gene FLOWERING LOCUS T (FT) exhibits a 24‐h circadian rhythm under long‐day (LD) conditions. Here we focus on the chromatin‐based mechanism regarding the control of FT expression.

We conducted co‐immunoprecipitation assays along with LC‐MS/MS analysis and identified HD2C histone deacetylase as the binding protein of the H3K4/H3K36 methylation reader MRG2.

HD2C and MRG1/2 regulate flowering time under LD conditions, but not under short‐day conditions. Moreover, HD2C functions as an effective deacetylase in planta, mainly targeting H3K9ac, H3K23ac and H3K27ac. At dusk, HD2C is recruited to FT to deacetylate histones and repress transcription in an MRG1/2‐dependent manner. More importantly, HD2C competes with CO for the binding of MRG2, and the accumulation of HD2C at the FT locus occurs at the end of the day.

Our findings not only reveal a histone deacetylation mechanism contributing to prevent FT overexpression and precocious flowering, but also support the model in which the histone methylation readers MRG1/2 provide a platform on chromatin for connecting regulatory factors involved in activating FT expression in response to daylight and decreasing FT expression around dusk under long days.
Prognostic significance of neutrophil‐to‐lymphocyte ratio in HPV status era for oropharyngeal cancer
Authors: Fanetti Giuseppe , Alterio Daniela , Marvaso Giulia , Gandini Sara , Rojas Damaris Patricia , Gobitti Carlo , Minatel Emilio , Revelant Alberto , Caroli Angela , Francia Claudia Maria , Alessandro Ombretta , Pepa Matteo , Gugliandolo Simone Giovanni , Starzyńska Anna , Polesel Jerry , Vaccher Emanuela , Cossu Rocca Maria , Tagliabue Marta , Ansarin Mohssen , Lupato Valentina , Giacomarra Vittorio , De Paoli Antonino , Orecchia Roberto , Franchin Giovanni , Jereczek‐Fossa Barbara Alicja 
Published: April 2020

AbstractAimTo evaluate the role of baseline neutrophil‐to‐lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status.Patients and methodsA retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression‐free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed.ResultsSeventy‐seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow‐up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two‐year OS was 91% and 81% in pts with NLR <3 and ≥3, respectively.ConclusionA baseline NLR ≥ 3 at treatment initiation represented a negative prognostic marker for OPC treated with definitive CRT. These results are in line with literature data, and prognostic value of NLR has been confirmed restaging our cohort with new TNM staging (8th ed.). Therefore, NLR could be considered a valuable biomarker for risk stratification in pts with OPC.
Identifying heterotic groups and testers for hybrid development in early maturing yellow maize (Zea mays) for sub‐Saharan Africa
Authors: Annor Benjamin , Badu‐Apraku Baffour , Nyadanu Daniel , Akromah Richard , Fakorede Morakinyo A. B. 
Published: April 2020

AbstractIdentification of heterotic groups and efficient testers, which are important prerequisites for the development of outstanding hybrids, has been a major challenge to its success, especially for early and extra‐early germplasm. This study was carried out to (a) identify the most efficient heterotic grouping method for classifying a set of inbred lines and (b) determine the efficiency of testers in classifying inbred lines into heterotic groups. A total of 205 hybrids obtained by crossing 41 inbred lines with five standard testers were evaluated together with five hybrid checks under drought, low soil nitrogen (N),Striga‐infested and optimal environments in Nigeria between 2014 and 2016. The heterotic group's specific and general combining ability (HSGCA) method was more effective in classifying the inbred lines into heterotic groups. Testers TZEI 17 and TZEI 23 were the most efficient across environments and could be invaluable for classifying other lines into heterotic groups and assessing combining ability of maize inbreds. In addition, these testers and heterotic groups represent an invaluable resource for development of outstanding hybrids in sub‐Saharan Africa (SSA).
Use of an emollient‐containing diaper and pH‐buffered wipe regimen restores skin pH and reduces residual enzymatic activity
Authors: Gustin Jennifer , Bohman Lisa , Ogle Julie , Chaudhary Tanuja , Li Lijuan , Fadayel Gina , Mitchell Maria C. , Narendran Vivek , Visscher Marty O. , Carr Andrew N. 
Published: April 2020

AbstractBackground/ObjectivesDiaper dermatitis is one of the most frequent skin conditions affecting infants and is associated with elevated skin pH, exposure to urine and feces, and increased fecal protease and lipase activity, resulting in stratum corneum barrier damage and increased risk of infection. The study aim was to determine the impact of two diaper and wipe regimens on newborn infant skin pH and residual enzyme activity after stool cleaning.MethodsTwo diaper and wipe regimens were compared in a randomized, single‐blinded crossover study. Regimen A paired an emollient‐containing diaper with an acidic, pH‐buffered wipe. Regimen B was a non‐emollient diaper and wipe with limited buffering capacity. A 3‐day washout period preceded each 3‐day regimen use period. Skin pH at the perianal/buttocks interface (PBI), genital region, and undiapered chest control were measured at baseline and day 3. Skin swabs were collected for residual enzyme activity after a stool cleaning event.ResultsDiapered skin pH at the PBI was similar to undiapered skin after 3 days of use for Regimen A, while PBI pH for Regimen B was elevated versus control. PBI pH was lower for Regimen A versus Regimen B. After a stool cleaning, PBI skin pH for Regimen A was lower immediately and had lower residual enzyme activity versus Regimen B (P < .05), and the pH‐lowering effect was sustained up to 60 minutes.ConclusionsThese results suggest that the use of an emollient‐containing diaper with a pH‐buffered wipe creates conditions favorable to optimum diapered skin health.
Workplace events and employee creativity: A multistudy field investigation
Authors: Chen Yang , Liu Dong , Tang Guiyao , Hogan Toschia M. 
Published: April 2020

AbstractA burgeoning body of research has examined the influence of stable attributes of individuals, teams, and organizations on employee creativity. Events, however, permeate the increasingly dynamic and uncertain business context. To extend the creativity literature, we draw on event system theory to examine whether, when, and how workplace events impact employee creativity. Our findings based on two time‐lagged field studies reveal that workplace event novelty and criticality interact to fuel employee improvisation and in turn, employee creativity. The positive relationship between workplace event novelty and employee improvisation is stronger when workplace events are more critical. Our research highlights the value of an event‐oriented theory‐building approach to investigate dynamic organizational phenomena.
Temporal Disaggregation of Overlapping Noisy Quarterly Data: Estimation of Monthly Output from Uk Value-added Tax Data
Authors: Labonne Paul , Weale Martin 
Published: April 2020

SummaryThe paper derives monthly estimates of business sector output in the UK from rolling quarterly value-added tax based turnover data. The administrative nature of the value-added tax data implies that their use could ultimately yield a more precise and granular picture of output across the economy. However, they show two particular features which complicate their exploitation: they are overlapping and subject to substantial noise. This motivates our choice of a multivariate unobserved components model for filtering and disaggregating temporally the aggregate figures. After illustrating our method by using one industry as a case-study, we estimate monthly seasonally adjusted gross output figures for the 75 industries for which the data are available. Our results show material differences from the existing output profile.
Effects on nitrate leaching of the timing of cattle slurry application to leys
Authors: Delin Sofia , Stenberg Maria 
Published: April 2020

AbstractThis study compared the effects on nitrate leaching of slurry application to ley in early autumn (15 September), late autumn (1 November) and spring (April) under Swedish growing conditions. In two separate two‐year experiments, started in autumn 2009 and 2010, on a sandy loam soil in south‐west Sweden, these three application times were compared with no slurry application in grass–clover and grass swards. Soil water was sampled with ceramic suction cups, and nitrate leaching was calculated from water nitrate concentrations and drain discharge. Plant measurements indicated that, during autumn, the grass took up at least 20 kg of the 50 kg nitrogen (N) applied with slurry in September. The mineral nitrogen level in the subsoil (30–90 cm) in December was around 2 kg N ha−1 higher in this treatment. Nitrate leaching was on average 5 and 6 kg N ha−1 year−1 higher after early and late autumn slurry application, respectively, than after spring application (p < .001), but the difference varied from 0 to 10 kg N ha−1 year−1 between experiments and sward types. Nitrate leaching losses in kg N ha−1 were lower from the grass sward, but higher if related to nitrogen inputs and dry matter yield. These results indicate that autumn application can increase the risk of nitrate leaching, but that early/late application within autumn is less important. It is more important to limit the amount of slurry applied in autumn and to consider other risks of nitrogen losses associated with time of application, such as ammonia emissions.
Peeling back the layers of crassulacean acid metabolism: functional differentiation between Kalanchoë fedtschenkoi epidermis and mesophyll proteomes
Authors: Abraham Paul E. , Hurtado Castano Natalia , Cowan‐Turner Daniel , Barnes Jeremy , Poudel Suresh , Hettich Robert , Flütsch Sabrina , Santelia Diana , Borland Anne M. 
Published: April 2020

SummaryCrassulacean acid metabolism (CAM) is a specialized mode of photosynthesis that offers the potential to engineer improved water‐use efficiency (WUE) and drought resilience in C3 plants while sustaining productivity in the hotter and drier climates that are predicted for much of the world. CAM species show an inverted pattern of stomatal opening and closing across the diel cycle, which conserves water and provides a means of maintaining growth in hot, water‐limited environments. Recent genome sequencing of the constitutive model CAM species Kalanchoë fedtschenkoi provides a platform for elucidating the ensemble of proteins that link photosynthetic metabolism with stomatal movement, and that protect CAM plants from harsh environmental conditions. We describe a large‐scale proteomics analysis to characterize and compare proteins, as well as diel changes in their abundance in guard cell‐enriched epidermis and mesophyll cells from leaves of K. fedtschenkoi. Proteins implicated in processes that encompass respiration, the transport of water and CO2, stomatal regulation, and CAM biochemistry are highlighted and discussed. Diel rescheduling of guard cell starch turnover in K. fedtschenkoi compared with that observed in Arabidopsis is reported and tissue‐specific localization in the epidermis and mesophyll of isozymes implicated in starch and malate turnover are discussed in line with the contrasting roles for these metabolites within the CAM mesophyll and stomatal complex. These data reveal the proteins and the biological processes enriched in each layer and provide key information for studies aiming to adapt plants to hot and dry environments by modifying leaf physiology for improved plant sustainability.
Genome‐wide binding analysis reveals that ANAC060 directly represses sugar‐induced transcription of ABI5 in Arabidopsis
Authors: Yu Bo , Wang Yuejun , Zhou Hua , Li Ping , Liu Chunmei , Chen Sunlu , Peng Yu , Zhang Yijing , Teng Sheng 
Published: April 2020

SUMMARYThe sugar status of a plant acts as a signal affecting growth and development. The phenomenon by which high levels of sugars inhibit seedling establishment has been widely used to gain insight into sugar‐signaling pathways. Natural allelic variation has been identified at the ANAC060 locus. The Arabidopsis Columbia ecotype produces a short ANAC060 protein without a transmembrane domain that is constitutively located to the nucleus, causing sugar insensitivity when overexpressed. In this study, we generated a genome‐wide DNA‐binding map of ANAC060 via chromatin immunoprecipitation sequencing using transgenic lines that express a functional ANAC060–GFP fusion protein in an anac060 background. A total of 3282 genes associated with ANAC060‐binding sites were identified. These genes were enriched in biotic and abiotic stress responses, and the G‐box binding motif was highly enriched in ANAC060‐bound genomic regions. Expression microarray analysis resulted in the identification of 8350 genes whose activities were altered in the anac060 mutant and upon sugar treatment. Cluster analysis revealed that ANAC060 attenuates sugar‐regulated gene expression. Direct target genes of ANAC060 included equivalent numbers of genes that were upregulated or downregulated by ANAC060. The various functions of these target genes indicate that ANAC060 has several functions. Our results demonstrate that ANAC060 directly binds to the promoter of ABI5 and represses the sugar‐induced transcription of ABI5. Genetic data indicate that ABI5 is epistatic to ANAC060 in both sugar and abscisic acid responses.
A mutation in the essential and widely conserved DAMAGED DNA BINDING1‐Cullin4 ASSOCIATED FACTOR gene OZS3 causes hypersensitivity to zinc excess, cold and UV stress in Arabidopsis thaliana
Authors: Weber Michael , Beyene Blen , Nagler Nicole , Herfert Jörn , Schempp Stefanie , Klecker Maria , Clemens Stephan 
Published: April 2020

SUMMARYThe overly zinc sensitive Arabidopsis thaliana mutant ozs3 shows reduced growth of the primary root, which is exacerbated by an excess specifically of Zn ions. In addition, ozs3 plants display various subtle developmental phenotypes, such as longer petioles and early flowering. Also, ozs3 seedlings are completely but reversibly growth‐arrested when shifted to 4°C. The causal mutation was mapped to a gene encoding a putative substrate‐recognition receptor of cullin4 E3 ligases. OZS3 orthologous genes can be found in almost all eukaryotic genomes. Most species from Schizosaccharomyces pombe to Homo sapiens, and including A. thaliana, possess one ortholog. No functional data are available for these genes in any of the multicellular model systems. CRISPR‐Cas9‐mediated knockout demonstrated that a complete loss of OZS3 function is embryo‐lethal, indicating essentiality of OZS3 and its orthologs. The OZS3 protein interacts with the adaptor protein DAMAGED DNA BINDING1 (DDB1) in the nucleus. Thus, it is indeed a member of the large yet poorly characterized family of DDB1‐cullin4 associated factors in plants. Mutant phenotypes of ozs3 plants are apparently caused by the weakened DDB1–OZS3 interaction as a result of the exchange of a conserved amino acid near the conserved WDxR motif.
Comparison of Single-Phase Convection in Additive Manufactured Versus Traditional Metal Foams
Authors: Broughton Justin , Joshi Yogendra K. 
Published: April 2020

Abstract
Metal foams have been often used for thermal management due to their favorable characteristics including high specific surface area (SSA), high thermal conductivity, and low relative density. However, they are accompanied by shortcomings including the significant contact resistances due to attachment method, as well as the need for characterization of foam parameters such as pore diameter and SSA. Additive manufactured (AM) metal foams would eliminate the substrate/foam thermal resistance, decrease the need for pre-usage characterization, and allow for tailoring structures, while also taking advantage of the characteristics of traditionally manufactured foams. A commercial, aluminum foam (nominally 5 pores per inch (PPI), 86.5% porosity) was analyzed using X-ray microcomputed tomography, and a custom-designed metal foam based on the cell diameter and porosity of the commercial sample was subsequently manufactured. Reduced domain computational fluid dynamics/heat transfer (CFD-HT) models were compared against experimental data. Postvalidation, the flow behavior, effect of varying attachment thermal conductivities, and thermal performance were numerically investigated, demonstrating the usefulness of validated pore-scale models, as well as the potential for improved performance using AM metal foams over traditionally manufactured foams.