bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maxillary Growth Evaluation Of Patients With Unilateral Complete Cleft Lip And Palate After Two Flap Palatoplasty With Honey Oral Drops
Authors: Kreshanti Prasetyanugraheni , Handayani Siti , Fortuna Forry , Pancawati Julieta , Susanto Amila Jeni , Wangge Grace , Indania Alita 
Published: October 2019

Background : Honey given as oral drops significantly precipitate epithelialization of the lateral palatal defects post two-flap palatoplasty by 2.1 times. Honey is believed to reduce wound contraction, scar formation, and would contribute as an important factor that will result in a satisfactory maxillary growth. The aim of this study is to evaluate maxillary growth as the long-term effect of rapid epithelialization of the palates treated by honey oral drops.
Method : This is a case control study consisting of 2 groups; comparing maxillary growth of the UCCLP patients that were and were not given honey as oral drops following their two-flap palatoplasty in 2011-2012. The cephalometric measurements were recorded and the dental cast are evaluated using GOSLON Yardstick method.Result : This study included a total of 20 patients. Goslon Yardstick type IV are the most frequent GOSLON on both groups (40%) with moderate inter-rater reliability between examiner 1-2 and 2-3 (kappa; 0.583 and 0.512) and substantial between examiner 1-3 (kappa 0.716). Forty-percent of SNA angle in the honey group were considered as normal, while only 20% normal SNA angle were found in the control group.Conclusion: Honey oral drops following two-flap palatoplasty resulted in satisfactory SNA angle. As the completion of maxillary growth occurs at the age of 20, the results of this study would only serve as a preliminary report. Other measures to support maxillary growth should also be taken into account. Further studies are warranted to discover innovations in surgical technique that may be a major contributing factor in maxillary growth.

Keywords: Maxillary growth, Two Flap Palatoplasty, honey
Association Between Serum Albumin And The Success Of Fluid Resuscitation In Children Hospitalizen In Cipto Mangunkusumo Hospital Burn Center
Authors: Dewi Rismala , Kaltha Karina , Wardhana Aditya , Yanuarso Piprim B. 
Published: October 2019

Background : Burn injury has a great impact on mortality and morbidity in children. Significant loss of albumin (hypoalbuminemia) in burn patient often leads to serious complications. However, it is still unclear whether serum albumin has a role in the success of fluid resuscitation in children with burn injury.
Method : This is a retrospective cohort study based on medical record of children hospitalized with burn injury at Cipto Mangunkusumo Hospital Burn Centre from January 2012-March 2018. The subjects collected with the total sampling method.
Result : Most burn injury happen because of scalds, and have grade 2 burn injury with PELOD score<10. Almost all subjects was succesfully resuscitated in the first 24 hour (95,1%). No association was found between the success of fluid resuscitation with either serum albumin [RR 1,175(95%CI 0,3-4,4) p=0,812], or with ureum, creatinin, lactate level, weight and the degree/extent of the burn injury.
Conclusion: The success rate of fluid resuscitation in pediatric burn injury was quite high in Cipto Mangunkusumo Hospital Burn Centre. No association was found between serum albumin and the success of fluid resuscitation during the first 24 hour period.

Keywords: albumin, burn, pediatric, resuscitation
Progressive Muscular Dystrophy (Duchenne Type) (Case Report)
Authors: Winarno Soelatin , Indrawarman Indrawarman , Waloejo Sabdo , Kristianti Lydia 
Published: October 2019

Clinical findings of two brothers suffering from progressive muscular dystrophy pseudohypertrophic type according to Duchenne are reported. Literatures dealing with its clinical classification, biochemical disturbances, hypotheses of the pathogenesis, management of treatment, mode of action of A.T.P. and the pedigree have been briefly reported.
Progressive Muscular Dystrophy is a progressive disease affecting voluntary muscles; It is characterized by a decreased strength in the affected muscles with rapid or slow gradual progression. About 45% of the patients gave a history that at least another member of the family is affected by the disease. Pseudohypertrophic form (Duchenne type) is usually inherited as a recessive factor, often sexlinked.
Development and Validation of a Nomogram for Early Detection of Malignant Gallbladder Lesions
Authors: Chen Mingyu , Cao Jiasheng , Bai Yang , Tong Chenhao , Lin Jian , Jindal Vishal , Barchi Leandro Cardoso , Nadalin Silvio , Yang Sherry X. , Pesce Antonio , Panaro Fabrizio , Ariche Arie , Kai Keita , Memeo Riccardo , Bekaii-Saab Tanios , Cai Xiujun ,   Written on behalf of the AME Gallbladder Cancer Collaborative Group
Published: October 2019

OBJECTIVES:
Preoperative decision-making for differentiating malignant from benign lesions in the gallbladder remains challenging. We aimed to create a diagnostic nomogram to identify gallbladder cancer (GBC), especially for incidental GBC (IGBC), before surgical resection.

METHODS:
A total of 587 consecutive patients with pathologically confirmed gallbladder lesions from a hospital were randomly assigned to a training cohort (70%) and an internal validation cohort (30%), with 287 patients from other centers as an external validation cohort. Radiological features were developed by the least absolute shrinkage and selection operator logistic regression model. Significant radiological features and independent clinical factors, identified by multivariate analyses, were used to construct a nomogram.

RESULTS:
A diagnostic nomogram was established by age, CA19.9, and 6 radiological features. The values of area under the curve in the internal and external validation cohorts were up to 0.91 and 0.89, respectively. The calibration curves for probability of GBC showed optimal agreement between nomogram prediction and actual observation. Compared with previous methods, it demonstrated superior sensitivity (91.5%) and accuracy (85.1%) in the diagnosis of GBC. The accuracy using the nomogram was significantly higher in GBC groups compared with that by radiologists in the training cohort (P < 0.001) and similarly in each cohort. Notably, most of the IGBC, which were misdiagnosed as benign lesions, were successfully identified using this nomogram.

DISCUSSION:
A novel nomogram provides a powerful tool for detecting the presence of cancer in gallbladder masses, with an increase in accuracy and sensitivity. It demonstrates an unprecedented potential for IGBC identification.
Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing
Authors: Toma Claudio , Díaz-Gay Marcos , Soares de Lima Yasmin , Arnau-Collell Coral , Franch-Expósito Sebastià , Muñoz Jenifer , Overs Bronwyn , Bonjoch Laia , Carballal Sabela , Ocaña Teresa , Cuatrecasas Miriam , Díaz de Bustamante Aránzazu , Castells Antoni , Bujanda Luis , Cubiella Joaquín , Balaguer Francesc , Rodríguez-Alcalde Daniel , Fullerton Janice M. , Castellví-Bel Sergi 
Published: October 2019

OBJECTIVES:
Serrated polyposis syndrome (SPS) is a complex disorder with a high risk of colorectal cancer for which the germline factors remain largely unknown. Here, we combined whole-exome sequencing (WES) and linkage studies in families with multiple members affected by SPS to identify candidate genes harboring rare variants with higher penetrance effects.

METHODS:
Thirty-nine affected subjects from 16 extended SPS families underwent WES. Genome-wide linkage analysis was performed under linear and exponential models. The contribution of rare coding variants selected to be highly pathogenic was assessed using the gene-based segregation test.

RESULTS:
A significant linkage peak was identified on chromosome 3p25.2-p22.3 (maxSNP = rs2293787; LODlinear = 2.311, LODexp = 2.11), which logarithm of the odds (LOD) score increased after fine mapping for the same marker (maxSNP = rs2293787; LODlinear = 2.4, LODexp = 2.25). This linkage signal was replicated in 10 independent sets of random markers from this locus. To assess the contribution of rare variants predicted to be pathogenic, we performed a family-based segregation test with 11 rare variants predicted to be deleterious from 10 genes under the linkage intervals. This analysis showed significant segregation of rare variants with SPS in CAPT7, TMEM43, NGLY1, and FBLN2 genes (weighted P value > 0.007).

DISCUSSION:
Protein network analysis suggested FBLN2 as the most plausible candidate genes for germline SPS predisposition. Etiologic rare variants implicated in disease predisposition may be identified by combining traditional linkage with WES data. This powerful approach was effective for the identification of a new candidate gene for hereditary SPS.
Gottesbegriff und Gotteserkenntnis bei Constantin Brunner und Martin Buber
Authors: Werner Hans 
Published: October 2019

Abstract
The concept of God plays a prominent role in both Constantin Brunner’s and Martin Buber’s writings. In the way they treated this subject there are similarities, but also some striking differences. Both thinkers saw their philosophy as an attempt to explain the Absolute (Brunner) or God (Buber). Both were influenced by the philosophy of Spinoza and the tradition of mysticism. The crucial difference between Brunner and Buber is that Buber thinks of God as a person with whom a personal relationship is possible. Brunner, on his part, rejects any form of anthropomorphism and thinks of God as the Absolute, as an impersonal, unifying principle. Both interpretations point to a different understanding of religion and Judaism. For Brunner, Buber’s concept of God was an example of »superstition«, whereas Buber would have argued that Brunner does not understand the role of the Jewish God as a partner in dialogue.
An updated protocol based on CLSI document C37 for preparation of off-the-clot serum from individual units for use alone or to prepare commutable pooled serum reference materials
Authors: Danilenko Uliana , Vesper Hubert W. , Myers Gary L. , Clapshaw Patric A. , Camara Johanna E. , Miller W. Greg 
Published: October 2019

Abstract
Manufacturers of in vitro diagnostic medical devices, clinical laboratories, research laboratories and calibration laboratories require commutable reference materials that can be used in the calibration hierarchies of medical laboratory measurement procedures used for human specimens to establish metrological traceability to higher order reference systems. Commutable materials are also useful in external quality assessment surveys. In order to achieve these goals, matrix-based reference materials with long-term stability, appropriate measurand concentrations and commutability with individual human specimens are required. The Clinical and Laboratory Standards Institute (CLSI) guideline C37-A (now archived) provided guidance to prepare commutable pooled serum reference materials for use in the calibration hierarchies of cholesterol measurement procedures. Experience using the C37-A guideline has identified a number of technical enhancements as well as applications to measurands other than cholesterol. This experience is incorporated into this updated protocol to ensure the procedure will continue to meet the needs of the medical laboratory. The updated protocol describes a procedure for preparing frozen human serum units or pools with minimal matrix alterations that are likely to be commutable with individual human serum samples. The protocol provides step-by-step guidance for the planning phase, collection of individual serum units, processing the units, qualifying the units for use in a pool and frozen storage of aliquots of pooled sera to manufacture frozen serum pools. Guidance on how to perform quality control of the final product and suggestions on documentation are also provided.
Empowerment Rights and Happiness Gap in Post-socialist Countries
Authors: Lewczuk Anna 
Published: October 2019

AbstractIn this paper, we contribute to the debate on life-satisfaction gap between the citizens of post-socialist countries of Europe and Asia and their highly developed OECD counterparts, by examining the influence of de jure and de facto respect for empowerment rights. We mainly focus on the measure of rights protection called de jure - de facto rights protection gap. The empowerment rights included in the analysis are: the freedom of association, the freedom of expression, the freedom of religion, the freedom of foreign movement. Our results imply that government’s respect for these rights plays the role in diminishing happiness gap. We base the conclusions on an empirical study conducted on the sample of more than 59,000 observations. The data used for the study consist of World Values Survey database (waves 3–6) and a number of socio-economic indicators for 44 countries.
Modelling of Acoustic Wave Propagation Due to Partial Discharge and Its Detection and Localization in an Oil-Filled Distribution Transformer
Authors: Meitei Sorokhaibam Nilakanta , Borah Kunal , Chatterjee Saibal 
Published: October 2019

AbstractPartial discharge (PD) is the main cause of the insulation decay and hence periodical testing of the insulation condition of a distribution transformer is necessary. This paper presents a model of PD acoustic wave propagation, detection, and localization in an oil-filled distribution transformer using finite element method supported by COMSOL Multiphysics software. Using an acoustic module and AC/DC module of COMSOL Multiphysics software, oil filled distribution transformer, and the acoustic piezoelectric sensor are simulated to analyze and detect the PD inside the transformer. PD is numerically simulated in the transformer windings, core, and oil ducts that produce acoustic wave signal. The distribution of the acoustic pressure wave inside the model transformer is analyzed first. Next, the acoustic piezoelectric sensors are modelled at four different locations of the model transformer to detect the pressure acoustic wave signal induced due to PD in the transformer. Finally, using an artificial neural network (ANN), the localization, and identification of PD in various parts of the transformer have been analyzed. The results obtained for location and detection are quite encouraging.
Altercatio – Wortgefechte, Dissens und Konkurrenz in der senatorischen Debattenkultur des frühen Prinzipats
Authors: Künzer Isabelle 
Published: October 2019

Abstract
The ancient sources frequently mention heated debates during meetings of the Roman senate under the early empire. Such debates could become so intense they might even threaten to impede the Senate’s decision-making abilities. Nevertheless, senatorial debate in the curia was not necessarily dysfunctional: in fact, it had a crucial instrumental function. Potential dissent among members of the senate could be discussed and settled before voting began, taking it out of the decision-making process proper. The symbolic dimensions of senatorial altercationes were if possible even more important, because the existence of communicative dissent showed that discussions still happened in the curia: proof that the Senate was still a functioning political entity. A combined agent-centred and institutional-historical methodological approach allows us to track not only individual practices of dispute, competition, and raising one’s profile, but to perceive more clearly the impact and the function disputes had for the Senate’s debating culture as a whole.
Application of gradient method for separately analyzing optical and mechanical dot gain of electrophotography prints
Authors: Itrić Katarina , Modrić Damir , Milković Marin , Divjak Alan 
Published: October 2019

AbstractThe ultimate goal of each production process is to optimize all the subprocesses leading to the high quality final product. Within the printing process, dot gain is identified as one of the most important variables to control because of the extremely negative impact to middle tone contrast and the overall reproduction. Dot gain consists of two components, mechanical and optical dot gain, as a result of two different contributions. This article proposes a model for separately analyzing components of dot gain for electrophotography prints using gradient method, where the impact of printing technique and paper type will be examined. It is shown that mechanical dot gain for electrophotography prints can be satisfactorily approximated with Gaussian, whilst optical dot gain is once again confirmed to have the form of a Lorentzian.
Effect of PVA fiber on durability of cementitious composite containing nano-SiO2
Authors: Zhang Peng , Li Qing-fu , Wang Juan , Shi Yan , Ling Yi-feng 
Published: October 2019

Abstract
In the current investigation, the influence of polyvinyl alcohol (PVA) fibers on flowability and durability of cementitious composite containing fly ash and nano-SiO2 was evaluated. PVA fibers were added into the composite at a volume fraction of 0.3%, 0.6%, 0.9%, and 1.2%. The flowability of the fresh cementitious composite was assessed using slump flow. The durability of cementitious composite includes carbonation resistance, permeability resistance, cracking resistance as well as freezing-thawing resistance, which were evaluated by the depth of carbonation, the water permeability height, cracking resistance ratio of the specimens, and relative dynamic elastic modulus of samples after freeze-thaw cycles, respectively. The results indicated that addition of PVA fibers had a little disadvantageous influence on flowability of cementitious composite, and the flowability of the fresh mixtures decreased with increases in PVA fiber content. Incorporation of PVA fibers significantly improved the durability of cementitious composites regardless of addition of nano-particles. When the fiber content was less than 1.2%, the durability indices of permeability resistance and cracking resistance increased with fiber content. However, the durability indices of carbonation resistance and freezing-thawing resistance began to decrease as the fiber dosage increased from 0.9% to 1.2%. The fiber reinforced cementitious composite exhibited better durability due to addition of nano-SiO2 particles. Nano-SiO2 particle improves microscopic structure of fiber reinforced cementitious composites, and the nano-particles are beneficial for PVA fibers to play the role of reinforcement in cementitious composites.
Cr effects on the electrical contact properties of the Al2O3-Cu/15W composites
Authors: Zhang Xiaohui , Zhang Yi , Tian Baohong , Jia Yanlin , Liu Yong , Song Kexing , Volinsky Alex. A. , Xue Huihui 
Published: October 2019

Abstract
In order to investigate the effects of chromium on the electrical contact properties of the Al2O3-Cu/15W composites, vacuum hot-pressing sintering and internal oxidation methods were employed to fabricate the Al2O3-Cu/15W and Al2O3-Cu/15W5Cr composites. The microstructure was analyzed by scanning and transmission electron microscopy. The electrical contacts testing was performed using the JF04C testing machine at 30 V DC with 10-30 A current. The effects of Cr on the comprehensive properties, arc erosion morphology and welding force of the electrical contacts were investigated. The mass transfer mechanism was discussed. It was demonstrated that the Al2O3 nanoparticles pinned dislocations. The diffraction spots of the Cu matrix and the γ-Al2O3 disclose an orientation relationship of <103>Cu//<103>γ−Al2O3,{020}Cu//{040}γ−Al2O3. A typical arc erosion morphology, such as needle-like and coral structures was formed, which provides significantly enhanced arc erosion resistance of the contact material. Compared with the Al2O3-Cu/15W composite, the Al2O3-Cu/15W5Cr composite has a lower welding force. The two composites present two distinct mass transfer trends before and after 25 A. The final mass transfer direction of the composites is from the cathode to the anode. The Al2O3-Cu/15W5Cr contacts have less mass change under all testing conditions.
CRS and HIPEC in patients with peritoneal metastasis secondary to colorectal cancer: The small-bowel PCI score as a predictor of survival
Authors: Spiliotis John , Kalles Vasileios , Kyriazanos Ioannis , Terra Alexios , Prodromidou Anastasia , Raptis Apostolos , Kopanakis Nikolaos , Christopoulou Athina 
Published: October 2019

AbstractBackgroundCombining cytoreductive surgery (CRS) with Hyperthermic IntraPeritoneal Chemotherapy (HIPEC) can benefit patients with peritoneal metastasis from colorectal cancer. The present study evaluates the small bowel subset of the Peritoneal Cancer Index (Small-Bowel-PCI score (SB-PCI), min-max 0–12) as a prognostic factor in such patients.MethodsWe retrospectively analyzed patients that underwent CRS and HIPEC for recurrent colorectal cancer with peritoneal metastasis. Patient characteristics, procedure details, and clinical outcomes were evaluated.ResultsEighty patients were included. The mean intraoperative PCI-score was 16.8, with a mean SB-PCI score of 5.9. CC0/1 was achieved in 62/80 patients. The mean follow-up period was 26.3 months. Univariate regression analysis showed that the ECOG status, the presence of severe complications, the HIPEC regimen (oxaliplatin vs. mitomycin-C), the PCI score, the SB-PCI score and the completeness of cytoreduction correlated significantly with overall survival. In multivariate analysis, the SB-PCI and CC score were identified as independent prognostic factors of survival. When the SB-PCI was stratified in three groups (0–4, 5–8 and 9–12), Kaplan–Meier curve analysis showed significant difference in survival (p<0.001).ConclusionsThe SB-PCI correlates with overall survival in patients with peritoneal metastases secondary to colorectal cancer in this retrospective cohort. Its use should be validated in prospective patient series.
The nonlinear effects of uncertainty shocks
Authors: Jackson Laura E. , Kliesen Kevin L. , Owyang Michael T. 
Published: October 2019

Abstract
We consider the effects of uncertainty shocks in a nonlinear VAR that allows uncertainty to have amplification effects. When uncertainty is relatively low, fluctuations in uncertainty have small, linear effects. In periods of high uncertainty, the effect of a further increase in uncertainty is magnified. We find that uncertainty shocks in this environment have a more pronounced effect on real economic variables. We also conduct counterfactual experiments to determine the channels through which uncertainty acts. Uncertainty propagates through both the household consumption channel and through businesses delaying investment, providing substantial contributions to the decline in GDP observed after uncertainty shocks. Finally, we find evidence of the ability of systematic monetary policy to mitigate the adverse effects of uncertainty shocks.