bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus
Authors: Salz Andree , Gurniak Christine , Jönsson Friederike , Witke Walter 
Published: January 2020

ABSTRACT
Actin dynamics is essential for T-cell development. We show here that cofilin1 is the key molecule for controlling actin filament turnover in this process. Mice with specific depletion of cofilin1 in thymocytes showed increased steady-state levels of actin filaments, and associated alterations in the pattern of thymocyte migration and adhesion. Our data suggest that cofilin1 is controlling oscillatory F-actin changes, a parameter that influences the migration pattern in a 3-D environment. In a collagen matrix, cofilin1 controls the speed and resting intervals of migrating thymocytes. Cofilin1 was not involved in thymocyte proliferation, cell survival, apoptosis or surface receptor trafficking. However, in cofilin1 mutant mice, impaired adhesion and migration resulted in a specific block of thymocyte differentiation from CD4/CD8 double-positive thymocytes towards CD4 and CD8 single-positive cells. Our data suggest that tuning of the dwelling time of thymocytes in the thymic niches is tightly controlled by cofilin1 and essential for positive selection during T-cell differentiation. We describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.
Ο χορός ως αντικείμενο επιστημονικής έρευνας και φιλοσοφίας. Προλεγόμενα
Authors: Lazou Anna 
Published: January 2020

The art of dance is now studied in the sciences and philosophy. From the time of the ancient Greek thinkers to the modern era, dance has never ceased to be considered a way of expressing multiple potentialities of culture. The way that man danced in history is also a reflection on every era of man's relationship with nature, the universe and social structures.By selecting the most significant of all references to dance that the modern reader may encounter today, we locate the wealth and variety of information and approaches as well as the interdisciplinary nature of the studies provided. However, both the historical as well as the literary sources and the more recent ethnological and anthropological approaches do not cease to remain in an informational and encyclopedic field, without completing the theoretical explanation and understanding of the phenomenon unless and until specific philosophical questions are answered. These latter ones have to do with the identity of dance experience – based on data about the nature of learning, the relation of dance to language, science or sciences (history, philology, natural sciences), metaphysics and cosmology, the functionality and applicability of dance uses in society, religion and politics. Even the meaning of dance itself or the aesthetic principles as well as the moral and educational values of the ancient dance activity fall within traditional areas of philosophical contemplation or at least are not sufficiently systematized in the direction of methodical research unless they are subject to philosophical inquiry. We will focus on those facts which can show that orchesis/dance is treated by philosophy as an anthropological and at the same time cosmological concept referring to the relation of the human being to its inner psyche and to the environment. The "intelligence" of ancient Greek dance culture that has unfolded over many centuries, in various shapes and types of music poetry, but also with a rich social, educational and therapeutic functionality, is yet another discovery of the Greeks from their earliest history.
El precedente administrativo en Colombia: consolidación e implementación
Authors: Quecan Gamba Ricardo 
Published: January 2020

El concepto del precedente administrativo es una institución jurídica reciente para el ordenamiento jurídico colombiano, su incorporación legal es producto de la jurisprudencia de la Corte Constitucional de la última década, que impulsó al legislador a incorporar esta figura por medio de las Leyes 1340 de 2009 –Ley de protección de competencia- y 1437 de 2011-Código de Procedimiento Administrativo y de lo Contencioso Administrativo-. Esta institución jurídica en la actualidad representa grandes desafíos tanto teóricos como pragmáticos, ya que al otorgarle fuerza vinculante a las decisiones adoptadas por la administración en ocasiones pasadas, con el ánimo de aplicar uniformemente la misma decisión cuando se presente una similitud de circunstancias fácticas y jurídicas, le permite a dichas entidades ser directamente una fuente de Derecho, y con ello, generar todas las consecuencias que ello implica.
Social Structures and Reputation in Expert Review Systems
Authors: Chung Kevin , Kim Keehyung , Lim Noah 
Published: January 2020

We model an expert review system where two producers competing for market share each are evaluated by two raters. Employing economics experiments, the paper examines how the rater’s incentive to provide objective feedback can be distorted in the presence of social ties and different penalty structures for assigning unobjective ratings. The results reject the self-interested model. We find that raters assign more biased ratings to help the producer they know compete, and this distortion is exacerbated when the reputation cost for rating unobjectively is lowered. Counterintuitively, when both of the raters know the same producer, the likelihood of biased ratings drops significantly. To explain the empirical regularities, we develop a behavioral economics model and show that the rater’s utility function should account not only for social preferences toward the producer, but also the rater’s psychological aversion toward favoring a producer more than the other rater. Our findings demonstrate that it is critical for policymakers to be cognizant of the nonpecuniary factors that can influence behavior in expert review systems. This paper was accepted by John List, behavioral economics.
Positive transcriptional response on inflammation and joint remodelling influenced by physical exercise in proteoglycan-induced arthritis: An animal study
Authors: González-Chávez Susana A. , Pacheco-Tena César , Quiñonez-Flores Celia M. , Espino-Solis Gerardo P. , Burrola-De Anda Jessica I. , Muñoz-Morales Perla M. 
Published: January 2020

Aims To assess the effect of physical exercise (PE) on the histological and transcriptional characteristics of proteoglycan-induced arthritis (PGIA) in BALB/c mice. Methods Following PGIA, mice were subjected to treadmill PE for ten weeks. The tarsal joints were used for histological and genetic analysis through microarray technology. The genes differentially expressed by PE in the arthritic mice were obtained from the microarray experiments. Bioinformatic analysis in the DAVID, STRING, and Cytoscape bioinformatic resources allowed the association of these genes in biological processes and signalling pathways. Results Arthritic mice improved their physical fitness by 42.5% after PE intervention; it induced the differential expression of 2,554 genes. The bioinformatic analysis showed that the downregulated genes (n = 1,371) were significantly associated with cellular processes that mediate the inflammation, including Janus kinase-signal transducer and activator of transcription proteins (JAK-STAT), Notch, and cytokine receptor interaction signalling pathways. Moreover, the protein interaction network showed that the downregulated inflammatory mediators interleukin (IL) 4, IL5, IL2 receptor alpha (IL2rα), IL2 receptor beta (IL2rβ), chemokine ligand (CXCL) 9, and CXCL12 were interacting in several pathways associated with the pathogenesis of arthritis. The upregulated genes (n = 1,183) were associated with processes involved in the remodelling of the extracellular matrix and bone mineralization, as well as with the processes of aerobic metabolism. At the histological level, PE attenuated joint inflammatory infiltrate and cartilage erosion. Conclusion Physical exercise influences parameters intimately linked to inflammatory arthropathies. Research on the effect of PE on the pathogenesis process of arthritis is still necessary for animal and human models. Cite this article: Bone Joint Res. 2020;9(1):36–48.
Asymmetric compressive stability of rotating annular plates
Authors: Kiani Y , Bagheri H. , Eslami M. R. 
Published: January 2020

In the present research, buckling behaviour of an isotropic homogeneous rotating annular plate subjected to uniform compression on both inner and outer edges is analysed. It is further assumed that the plate is rotatingwith a constant angular speed. Formulation is based on the first order shear deformation plate theory, which is valid for thin and moderately thick plates. The complete set of equilibrium quations and the associated boundary conditions are obtained for the plate. Prebuckling loads of the plate are obtained under flatness and axisymmetric deformations. Using the adjacent equilibrium riterion, the linearised stability equations are extracted. An asymmetric stability analysis is performed to obtain the critical buckling loads of the plate and the buckled configurations of the rotating plate. To this end, trigonometric functions through the circumferential direction and the generalised differential quadrature discretization across the radial direction are used which result in an algebraic eigenvalue problem. Benchmark results are given in graphical presentations for combinations of free, simply-supported, sliding supported, and clamped types of boundary conditions. It is shown that rotation enhances the buckling loads of the plate for all types of boundary conditions and alters the buckled shape of the plate.
24.6  kW near diffraction limit quasi-continuous-wave Nd:YAG slab laser based on a stable–unstable hybrid cavity
Authors: Guo Yading , Peng Qinjun , Bo Yong , Chen Zhongzheng , Li Yang , Zhang Lin , Shao Chongfeng , Yuan Lei , Wang Baoshan , Xu Jian , Xu Jialin , Gao Hongwei , Xu Yiting , Lai Boheng , Su Chunxuan , Ma Shiqing , Cheng Tao 
Published: January 2020

A 24.6 kW quasi-continuous-wave (QCW) Nd-doped yttrium aluminum garnet (Nd:YAG) slab laser is proposed in this Letter. The laser is based on a stable–unstable hybrid cavity. A stable and an unstable resonator were constructed along orthogonal directions in the aperture of the slab. Due to features of the hybrid cavity, the slab laser achieves both high efficiency of power extraction with excellent beam quality and compactness with simplicity. Average output power of 24.6 kW with 47% optical-to-optical efficiency is achieved in the experiment. The beam quality of the output beam is 1.5 times diffraction limits after correction of adaptive optics. The repetition frequency and pulse width of the laser are 400 Hz and 200 μs.
Laser-induced rotary micromotor with high energy conversion efficiency
Authors: Zhang Yu , Lin Siyu , Liu Zhihai , Zhang Yaxun , Zhang Jianzhong , Yang Jun , Yuan Libo 
Published: January 2020

Light is a precious resource that nature has given to human beings. Converting green, recyclable light energy into the mechanical energy of a micromotor is undoubtedly an exciting challenge. However, the performance of current light-induced micromotor devices is unsatisfactory, as the light-to-work conversion efficiency is only

10

−
15

–

10

−
12

. In this paper, we propose and demonstrate a laser-induced rotary micromotor operated by

Δ
α

-type photopheresis in pure liquid glycerol, whose energy conversion ratio reaches as high as

10

−
9

, which is 3–6 orders of magnitude higher than that of previous light-induced micromotor devices. In addition, we operate the micromotor neither with a light field carrying angular momentum nor with a rotor with a special rotating symmetrical shape. We just employ an annular-core fiber to configure a conical-shaped light field and select a piece of graphite sheet (with an irregular shape) as the micro-rotor. The

Δ
α

-type photophoretic force introduced by the conical-shaped light field drives the rotation of the graphite sheet. We achieve a rotation rate up to 818.2 r/min, which can be controlled by tuning the incident laser power. This optical rotary micromotor is available for twisting macromolecules or generating vortex and shear force in a medium at the nanoscale.
Femtosecond mid-IR optical vortex laser based on optical parametric chirped pulse amplification
Authors: Qian Junyu , Peng Yujie , Li Yanyan , Wang Pengfei , Shao Beijie , Liu Zhe , Leng Yuxin , Li Ruxin 
Published: January 2020

A femtosecond mid-infrared optical vortex laser can be used for high harmonic generation to extend cutoff energy to the kilo-electron-volt range with orbital angular momentum, as well as other secondary radiations. For these, we demonstrate a high-energy femtosecond 4 μm optical vortex laser based on optical parametric chirped pulse amplification (OPCPA) for the first time. The optical vortex seed is generated from a femtosecond 4 μm laser by a silicon spiral phase plate with the topological charge

l

of 1 before the stretcher. Through using a two-stage collinear OPCPA amplifier, the chirped vortex pulse is amplified to 12.4 mJ with 200 nm full width at half-maximum bandwidth. After compression, the vortex laser pulse with 9.53 mJ, 119 fs can be obtained. Furthermore, the vortex characteristics of the laser beam are investigated and evaluated. This demonstration can scale to generate a higher-peak-power vortex mid-IR laser and pave a new way for high field physics.
Extensão universitária como compromisso social
Authors: Leite Maria Laís dos Santos 
Published: January 2020

(Re)ler o livro Educação e Mudança em tempos de crise político-econômica em nosso país, em que vivenciamos uma perseguição às universidades públicas, com cortes de recursos, ataques aos seus fazeres, ao papel do(a) professor(a), é realimentar-se de resistência, compromisso social, inclusive com a defesa da democracia. A temática central deste livro é a mudança, um dos “temas geradores” da prática teórica de Paulo Freire. Na obra, ele reflete sobre a mudança de uma sociedade de oprimidos para uma sociedade de iguais e o papel da educação e da conscientização nesse processo de mudança. Educação e Mudança é composto por quatro capítulos: O compromisso profissional com a sociedade; A educação e o processo de mudança social; O papel do trabalhador social no processo de mudança e Alfabetização de adultos e conscientização. Este texto objetiva, pois, apresentar contribuições dessa obra freiriana para a teoria/prática/pesquisa em extensão universitária
Dose and time-dependent acute and subchronic oral toxicity study of propoxazepam in mice and rats
Authors: Yakovlevich Golovenko Nikolay , Nikolayevna Kovalenko Valentina , Borisovich  Larionov Vitalii , Semenovich Reder Ðnatoliy 
Published: January 2020

Propoxazepam, 7-bromo-5 - (o-chlorophenyl)-3-propoxy - 1,2-dihydro - 3H-1,4-benzodiazepin-2-one, in the models of nociceptive and neuropathic pain showed significant analgesic activity. In order to explore clinical potential of propoxazepam for long term human consumption, toxicology testing in laboratory animals using well-accepted international guidelines is required. Acute toxicity tests were conducted by the oral administration of 2500; 3500; 4000; 4500 and 5000 mg/kg body weight to male and female mice and rats for a period of 3, 7 and 14 day. In subacute study, male rats were administered with various doses of propoxazepam (0.9, 4.5, and 9.0 mg/kg) to evaluate its toxicity for a period of 90 days. The effect of propoxazepam on body weight gain and organ weights, food and water consumptions were analyzed. From the present study, it can be concluded that the acute (3, 7 and 14 days) and subchronic (90 days) oral administrations of propoxazepam did not produce any clinical signs of toxicity or mortality of the male and female mice and rats. These results revealed that the LD50 of propoxazepam is greater than 5000 mg/kg and it therefore, belongs to the category V of relatively non-toxic substances according to the GHS. In the acute toxicity study, neither mortality no significant change in the body weight and the relative organ weights were recorded in all treated mice and rats. Present data set revealed that there wasn`t a strong correlation between body weight with food and water consumptions. The result indicates that the oral administration of propoxazepam did not produce any significant toxic effect in mice and rats and the substance can be safely used for therapeutic use in pharmaceutical formulations.Â Â
Compliance To Pay Zakat on Gold: A Study on UUM Staff
Authors: Sukri Fatihah Adilah 
Published: January 2020

Abstract: This paper aims to examine the relationship of attitude, religious value, knowledge on zakat, law of zakat as independent variable (IV) and compliance to pay zakat on gold as dependent variable (DV). A survey approach has been adopted in this study while the data are collected via structured questionnaires. The questionnaire was distributed to 250 respondents of Muslim women staff among academician and non-academician from three colleges in Universiti Utara Malaysia (UUM), Sintok Kedah. In this study, the researchers developed a new construct in measuring the compliance to pay zakat on gold, knowledge on zakat and law of zakat. While, the construct in measuring attitude and religious value variable are borrowed from the previous study. The data are then quantitatively analyzed using SPSS program. The findings shows a high significant and positive correlation between compliance to pay zakat on gold and knowledge on zakat followed by religious value, attitude and law of zakat. Further analysis using multiple regression analysis indicated that only knowledge on zakat, attitude and law of zakat give a significant and positive impact on zakat compliance payment on gold. The result of study contributed to the knowledge of zakat compliance. It is implied that the zakat authority need to intensify their efforts to further improve the effectiveness of education about zakat. Besides, it is proposed that zakat authority strives to cultivate a positive attitude of society towards zakat on gold using various strategic method.
Game Online Teka-Teki Silang dengan Software Hot Potatoes 6 untuk Mendukung Pembelajaran Ilmu Hadis
Authors: Imron Ali Imron 
Published: January 2020

Sebagai software yang sengaja dibuat oleh pengembangnya (Universitas Victoria, Kanada) untuk keperluan pendidikan, Hot Potatoes telah dimanfaatkan para praktisi pendidikan (baik guru maupun dosen) untuk membantu pembelajaran di kelas dari berbagai lintas ilmu. Artikel ini menjelaskan tentang plausibilitas penggunaan Software Hot Potatoes untuk membuat game atau permainan interaktif teka-teki silang untuk mendukung pembelajaran ilmu hadis.Sebagai software yang sengaja dibuat oleh pengembangnya (Universitas Victoria, Kanada) untuk keperluan pendidikan, Hot Potatoes telah dimanfaatkan para praktisi pendidikan (baik guru maupun dosen) untuk membantu pembelajaran di kelas dari berbagai lintas ilmu. Artikel ini menjelaskan tentang plausibilitas penggunaan Software Hot Potatoes untuk membuat game atau permainan interaktif teka-teki silang untuk mendukung pembelajaran ilmu hadis.
Influencias sociales en un modelo de insatisfacción corporal, preocupación por el peso y malestar corporal en mujeres mexicanas
Authors: Venegas-Ayala Karina Sugeyl , González-Ramírez Mónica Teresa 
Published: January 2020

El objetivo del presente estudio fue analizar el grado explicativo de las variables “influencia de la publicidad”, “mensajes verbales”, “modelos sociales” y “situaciones sociales” frente a la insatisfacción corporal, la preocupación por el peso y el malestar corporal en una muestra seleccionada por conveniencia de 206 mujeres mexicanas con promedio de edad de 22.12 años (DT = 4.21). Específicamente, se utilizó un modelamiento de ecuaciones estructurales para identificar los efectos directos e indirectos de las variables independientes sobre las dependientes en tres modelos hipotéticos propuestos, y como resultados se encontró que el conjunto de variables tuvo un valor explicativo de 79 % para el modelo planteado para la insatisfacción corporal, con buenos indicadores de bondad de ajuste (χ2/gl = .877; GFI = .982; CFI = .978; AGFI = .980; SRMR = .068; RMSEA = .079); de 62 % para el modelo de preocupación por el peso, con una adecuada bondad de ajuste (χ2/gl = 1.556; GFI = .981; CFI = .975; AGFI = .978; SRMR = .068; RMSEA = .080); y de 72 % para el modelo de malestar corporal, con buenos valores de bondad de ajuste (χ2/gl = .173; GFI = .976; CFI = .969; AGFI = .972; SRMR = .062; RMSEA = .072). Se concluye que las influencias sociales tienen un impacto significativo en la imagen corporal y que los mensajes verbales presentan un mayor impacto en las variables estudiadas.
Desempeño térmico de cerramientos de tierra alivianada Posibilidades de aplicación en el territorio peruano
Authors: Wieser-Rey Martín , Onnis Silvia , Meli Giuseppina 
Published: January 2020

Resumen
Las soluciones constructivas tradicionales y contemporáneas han demostrado tener serias limitaciones en la solución del déficit cualitativo y cuantitativo de la vivienda y el equipamiento, de igual manera, las evidencias del desempeño térmico son igualmente desalentadoras. Es por lo que se indaga sobre la capacidad de la tierra alivianada de brindar confort térmico en los edificios, considerando los diferentes climas del territorio peruano y comparándola con los sistemas constructivos más comunes en el medio: el adobe y la albañilería de ladrillo. A partir de la caracterización previa de las cualidades térmicas de los componentes y de la realización de simulaciones térmicas dinámicas, comparando el desempeño de diferentes prototipos digitales, se identificaron las virtudes de la tierra alivianada por el marcado equilibrio entre una masa térmica media y una conductividad térmica relativamente baja, siendo los únicos que logran cumplir con las exigencias de la actual norma peruana de eficiencia energética para el caso de los climas más fríos. Adicionalmente de destaca la composición a partir de materiales naturales, renovables y biodegradables que son ventajas ecológicas.
Palabras clave: arquitectura bioclimática; arquitectura sostenible; climatización pasiva; confort térmico; inercia térmica; simulación térmica; sistema constructivo; transmitancia térmica

Abstract
Traditional and contemporary construction systems have shown serious limitations in the solution of the qualitative and quantitative deficit of housing and equipment, in the same way, the evidence of thermal performance is equally discouraging. That is why we inquire about the ability of the land relieved to provide thermal comfort in buildings, considering the different climates of the Peruvian territory and comparing it with the most common construction systems in the environment: adobe and brick masonry. From the previous characterization of the thermal qualities of the components and the realization of dynamic thermal simulations, comparing the performance of different digital prototypes, the virtues of the earth alleviated by the marked balance between a medium thermal mass and a conductivity were identified relatively low thermal, being the only ones that manage to meet the requirements of the current Peruvian energy efficiency standard in the case of colder climates. In addition, the composition from natural, renewable and biodegradable materials that are ecological advantages stands out.
Keywords: bioclimatic architecture; sustainable architecture; passive air conditioning; Thermal comfort; thermal inertia; thermal simulation; construction system; thermal transmittance.

Recibido: febrero 25 / 2019 Evaluado: septiembre 20 / 2019 Aceptado: noviembre 23 / 2019
Publicado en línea: noviembre de 2019 Actualizado: noviembre de 2019