bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of vaporized nanoemulsions on ultrasound-mediated ablation
Authors: Zhang Peng , Kopechek Jonathan A , Porter Tyrone M 
Published: December 2019

Abstract

Background
The clinical feasibility of using high-intensity focused ultrasound (HIFU) for ablation of solid tumors is limited by the high acoustic pressures and long treatment times required. The presence of microbubbles during sonication can increase the absorption of acoustic energy and accelerate heating. However, formation of microbubbles within the tumor tissue remains a challenge. Phase-shift nanoemulsions (PSNE) have been developed as a means for producing microbubbles within tumors. PSNE are emulsions of submicron-sized, lipid-coated, and liquid perfluorocarbon droplets that can be vaporized into microbubbles using short (<1 ms), high-amplitude (>5 MPa) acoustic pulses. In this study, the impact of vaporized phase-shift nanoemulsions on the time and acoustic power required for HIFU-mediated thermal lesion formation was investigated in vitro.

Methods
PSNE containing dodecafluoropentane were produced with narrow size distributions and mean diameters below 200 nm using a combination of sonication and extrusion. PSNE was dispersed in albumin-containing polyacrylamide gel phantoms for experimental tests. Albumin denatures and becomes opaque at temperatures above 58°C, enabling visual detection of lesions formed from denatured albumin. PSNE were vaporized using a 30-cycle, 3.2-MHz, at an acoustic power of 6.4 W (free-field intensity of 4,586 W/cm2) pulse from a single-element, focused high-power transducer. The vaporization pulse was immediately followed by a 15-s continuous wave, 3.2-MHz signal to induce ultrasound-mediated heating. Control experiments were conducted using an identical procedure without the vaporization pulse. Lesion formation was detected by acquiring video frames during sonication and post-processing the images for analysis. Broadband emissions from inertial cavitation (IC) were passively detected with a focused, 2-MHz transducer. Temperature measurements were acquired using a needle thermocouple.

Results
Bubbles formed at the HIFU focus via PSNE vaporization enhanced HIFU-mediated heating. Broadband emissions detected during HIFU exposure coincided in time with measured accelerated heating, which suggested that IC played an important role in bubble-enhanced heating. In the presence of bubbles, the acoustic power required for the formation of a 9-mm3 lesion was reduced by 72% and the exposure time required for the onset of albumin denaturation was significantly reduced (by 4 s), provided that the PSNE volume fraction in the polyacrylamide gel was at least 0.008%.

Conclusions
The time or acoustic power required for lesion formation in gel phantoms was dramatically reduced by vaporizing PSNE into bubbles. These results suggest that PSNE may improve the efficiency of HIFU-mediated thermal ablation of solid tumors; thus, further investigation is warranted to determine whether bubble-enhanced HIFU may potentially become a viable option for cancer therapy.
Embedding edit distance to enable private keyword search
Authors: Bringer Julien , Chabanne Hervé 
Published: December 2019

AbstractBackgroundOur work is focused on fuzzy keyword search over encrypted data in Cloud Computing.MethodsWe adapt results on private identification schemes by Bringeret al. to this new context. We here exploit a classical embedding of the edit distance into the Hamming distance.ResultsOur way of doing enables some flexibility on the tolerated edit distance when looking for close keywords while preserving the confidentiality of the queries.ConclusionOur proposal is proved secure in a security model taking into account privacy.
Technical efficiency in the sheep dairy industry: an application on the Sardinian (Italy) sector
Authors: Furesi Roberto , Madau Fabio A , Pulina Pietro 
Published: December 2019

AbstractSardinia (Italy) is one of the most important European regions for sheep dairy and sheep milk cheese production. However the Sardinian sheep dairy industry is currently going through a dramatic crisis, and verifying whether it can recover part of its profitability is now a priority. Attention is now focused on estimating whether the sheep dairy firms can improve their productivity by more efficient use of their available technical resources. This paper aims to estimate technical efficiency in the Sardinian sheep dairy industry. A stochastic frontier analysis approach was used on panel data from 36 sheep dairy firms over the period 2004–2009 in order to assess whether there are some margins for technical improvements in productivity, given the existing level of technology. A comparative analysis of private firms and cooperatives was also carried out, in order to establish if there were differences in the technology they used and/or their efficiency in using technical inputs. Our findings suggest that there is technological homogeneity among the firms and between private firms and cooperatives. Technical efficiency is equal to 0.905 and it is significantly different between private firms (0.933) and cooperatives (0.877). Our findings have certain implications for what policies should be implemented in order to improve efficiency in the sector and on the orientation of decision makers strategies.
Magnetic properties of Cr-substituted Co-ferrite nanoparticles synthesized by citrate-gel autocombustion method
Authors: Raghasudha M , Ravinder D , Veerasomaiah P 
Published: December 2019

Abstract
A series of Co-Cr nanoferrites having the chemical formula CoCr
x
Fe2 − x
O4 (x = 0.0, 0.1, 0.3, 0.5, 0.7, 0.9, and 1.0) were synthesized by citrate-gel autocombustion method at a very low temperature (180°C). The X-ray diffraction analysis of as-synthesized powders and sintered powders has confirmed the formation of single-phase cubic spinel structure. The average particle size of the synthesized ferrites was 6 to 12 nm. Magnetic susceptibility measurements using Faraday magnetic susceptibility balance showed the paramagnetic nature of the ferrites. Magnetic properties of Co-Cr nanoferrites were measured using a vibrating sample magnetometer at room temperature in the applied field of 15 kOe. The saturation magnetization decreased from 33.84 to 13.83 emu/g with increase in Cr3+ concentrations, indicating the fact that the lesser magnetic Cr3+ ions substitute Fe3+ ions in the octahedral sublattice of the ferrite. With improvement in the magnetic properties, the synthesized nanoferrites become soft magnetic materials. Such materials are useful in transformer and motor cores to minimize the energy dissipation with the alternating fields associated with AC electrical applications. The coercivity of pure CoFe2O4 was larger than that of the Cr-doped cobalt ferrites.
Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats
Authors: Ganster Frédérique , Burban Mélanie , de la Bourdonnaye Mathilde , Fizanne Lionel , Douay Olivier , Loufrani Laurent , Mercat Alain , Calès Paul , Radermacher Peter , Henrion Daniel , Asfar Pierre , Meziani Ferhat 
Published: December 2019

Abstract
Introduction
Hydrogen sulfide (H2S) has been shown to improve survival in rodent models of lethal hemorrhage. Conversely, other authors have reported that inhibition of endogenous H2S production improves hemodynamics and reduces organ injury after hemorrhagic shock. Since all of these data originate from unresuscitated models and/or the use of a pre-treatment design, we therefore tested the hypothesis that the H2S donor, sodium hydrosulfide (NaHS), may improve hemodynamics in resuscitated hemorrhagic shock and attenuate oxidative and nitrosative stresses.

Methods
Thirty-two rats were mechanically ventilated and instrumented to measure mean arterial pressure (MAP) and carotid blood flow (CBF). Animals were bled during 60 minutes in order to maintain MAP at 40 ± 2 mm Hg. Ten minutes prior to retransfusion of shed blood, rats randomly received either an intravenous bolus of NaHS (0.2 mg/kg) or vehicle (0.9% NaCl). At the end of the experiment (T = 300 minutes), blood, aorta and heart were harvested for Western blot (inductible Nitric Oxyde Synthase (iNOS), Nuclear factor-κB (NF-κB), phosphorylated Inhibitor κB (P-IκB), Inter-Cellular Adhesion Molecule (I-CAM), Heme oxygenase 1(HO-1), Heme oxygenase 2(HO-2), as well as nuclear respiratory factor 2 (Nrf2)). Nitric oxide (NO) and superoxide anion (O2-) were also measured by electron paramagnetic resonance.

Results
At the end of the experiment, control rats exhibited a decrease in MAP which was attenuated by NaHS (65 ± 32 versus 101 ± 17 mmHg, P < 0.05). CBF was better maintained in NaHS-treated rats (1.9 ± 1.6 versus 4.4 ± 1.9 ml/minute P < 0.05). NaHS significantly limited shock-induced metabolic acidosis. NaHS also prevented iNOS expression and NO production in the heart and aorta while significantly reducing NF-kB, P-IκB and I-CAM in the aorta. Compared to the control group, NaHS significantly increased Nrf2, HO-1 and HO-2 and limited O2- release in both aorta and heart (P < 0.05).

Conclusions
NaHS is protective against the effects of ischemia reperfusion induced by controlled hemorrhage in rats. NaHS also improves hemodynamics in the early resuscitation phase after hemorrhagic shock, most likely as a result of attenuated oxidative stress. The use of NaHS hence appears promising in limiting the consequences of ischemia reperfusion (IR).
International recommendations for glucose control in adult non diabetic critically ill patients
Authors: Ichai Carole , Preiser Jean-Charles ,   for the Société Française d'Anesthésie-Réanimation (SFAR),   Société de Réanimation de langue Française (SRLF) and the Experts group
Published: December 2019

Abstract
Introduction
The purpose of this research is to provide recommendations for the management of glycemic control in critically ill patients.

Methods
Twenty-one experts issued recommendations related to one of the five pre-defined categories (glucose target, hypoglycemia, carbohydrate intake, monitoring of glycemia, algorithms and protocols), that were scored on a scale to obtain a strong or weak agreement. The GRADE (Grade of Recommendation, Assessment, Development and Evaluation) system was used, with a strong recommendation indicating a clear advantage for an intervention and a weak recommendation indicating that the balance between desirable and undesirable effects of an intervention is not clearly defined.

Results
A glucose target of less than 10 mmol/L is strongly suggested, using intravenous insulin following a standard protocol, when spontaneous food intake is not possible. Definition of the severe hypoglycemia threshold of 2.2 mmol/L is recommended, regardless of the clinical signs. A general, unique amount of glucose (enteral/parenteral) to administer for any patient cannot be suggested. Glucose measurements should be performed on arterial rather than venous or capillary samples, using central lab or blood gas analysers rather than point-of-care glucose readers.

Conclusions
Thirty recommendations were obtained with a strong (21) and a weak (9) agreement. Among them, only 15 were graded with a high level of quality of evidence, underlying the necessity to continue clinical studies in order to improve the risk-to-benefit ratio of glucose control.
Prediction of acid radical ion binding residues by K-nearest neighbors classifier
Authors: Liu Liu , Hu Xiuzhen , Feng Zhenxing , Zhang Xiaojin , Wang Shan , Xu Shuang , Sun Kai 
Published: December 2019

AbstractBackgroundProteins perform their functions by interacting with acid radical ions. Recently, it was a challenging work to precisely predict the binding residues of acid radical ion ligands in the research field of molecular drug design.ResultsIn this study, we proposed an improved method to predict the acid radical ion binding residues by using K-nearest Neighbors classifier. Meanwhile, we constructed datasets of four acid radical ion ligand (NO2−, CO32−, SO42−, PO43−) binding residues from BioLip database. Then, based on the optimal window length for each acid radical ion ligand, we refined composition information and position conservative information and extracted them as feature parameters for K-nearest Neighbors classifier. In the results of 5-fold cross-validation, the Matthew’s correlation coefficient was higher than 0.45, the values of accuracy, sensitivity and specificity were all higher than 69.2%, and the false positive rate was lower than 30.8%. Further, we also performed an independent test to test the practicability of the proposed method. In the obtained results, the sensitivity was higher than 40.9%, the values of accuracy and specificity were higher than 84.2%, the Matthew’s correlation coefficient was higher than 0.116, and the false positive rate was lower than 15.4%. Finally, we identified binding residues of the six metal ion ligands. In the predicted results, the values of accuracy, sensitivity and specificity were all higher than 77.6%, the Matthew’s correlation coefficient was higher than 0.6, and the false positive rate was lower than 19.6%.ConclusionsTaken together, the good results of our prediction method added new insights in the prediction of the binding residues of acid radical ion ligands.
Wheat straw increases the defense response and resistance of watermelon monoculture to Fusarium wilt
Authors: Tang Lili , Nie Shaorui , Li Wenhui , Fan Chao , Wang Siqi , Wu Fengzhi , Pan Kai 
Published: December 2019

AbstractBackgroundWheat straw is a rich resource worldwide. Straw return is an effective strategy to alleviate soil-borne diseases on monoculture watermelon. Previous studies focus on soil structure, physical and chemical properties; however, little is known about the molecular responses on host plant.ResultsNo significant difference on the population ofFusarium oxysporumf.sp. niveumrace 1(Fon1) in rhizosphere soil was found between control (no addition of wheat straw) and the treated groups (addition of 1% (T1) or 2% (T2) wheat straw). RNA-Seq analysis showed that 3419 differentially expressed genes were clustered into 8 profiles. KEGG analysis revealed that phenylpropanoid biosynthesis and plant hormone signal transduction were involved in wheat straw induced response in monoculture watermelon. Genes in lignin biosynthesis were found to be upregulated, and the lignin and auxin contents were higher in T1 and T2 compared to the control. Lignin was also enriched and the Fon1 population decreased in watermelon roots treated with wheat straw. The enzyme activities of phenylalanine ammonia-lyase and peroxidase were increased.ConclusionsOur data suggest that the addition of wheat straw enhances the defense response to Fon1 infection in watermelon through increasing lignin and auxin biosynthesis.
The impact of obstetric interventions and complications on women’s satisfaction with childbirth a population based cohort study including 16,000 women
Authors: Falk Maja , Nelson Marie , Blomberg Marie 
Published: December 2019

AbstractBackgroundAs a quality marker and a tool for benchmarking between units, a visual analogue scale (VAS) (ranging from 1 to 10) to estimate woman’s satisfaction with childbirth was introduced in 2014. This study aimed to assess how obstetric interventions and complications affected women’s satisfaction with childbirth.MethodsA retrospective cohort study including 16,775 women with an available VAS score who gave birth between January 2016 and December 2017. VAS score, maternal and obstetric characteristics were obtained from electronic medical records and crude and adjusted odds ratios (aOR) were calculated.ResultsThe total prevalence of dissatisfaction with childbirth (VAS 1–3) was 5.7%. The main risk factors for dissatisfaction with childbirth were emergency cesarean section, aOR 3.98 95% confidence interval (CI) 3.27–4.86, postpartum hemorrhage ≥2000 ml, aOR 1.85 95%CI 1.24–2.76 and Apgar score < 7 at five minutes, aOR 2.95 95%CI 1.95–4.47. The amount of postpartum hemorrhage showed a dose-response relation to dissatisfaction with childbirth. Moreover, labor induction, instrumental vaginal delivery, and obstetric anal sphincter injury were significantly associated with women’s dissatisfaction with childbirth. A total number of 4429/21204 (21%) women giving birth during the study period had missing values on VAS. A comparison of characteristics between women with and without a recorded VAS score was performed. There were statistically significant differences in maternal age and maternal BMI between the study population and excluded women due to missing values on VAS. Moreover, 64% of the women excluded were multiparas, compared to 59% in the study population.ConclusionsObstetric interventions and complications, including emergency cesareans section and postpartum hemorrhage, were significantly related to dissatisfaction with childbirth.Such events are common and awareness of these associations might lead to a more individualized care of women during and after childbirth.
Prevalence and determinants of anaemia in pregnant women receiving antenatal care at a tertiary referral hospital in Northern Ghana
Authors: Wemakor Anthony 
Published: December 2019

Abstract
Background
Anaemia during pregnancy is a major public health problem in developing countries. It is important to regularly monitor haemoglobin level in pregnancy and factors associated with it to inform clinical and preventive services. The aim of this study was to assess the prevalence and determinants of anaemia in pregnant women attending antenatal clinic (ANC) of a tertiary referral hospital in Northern Ghana.

Methods
An analytical cross-sectional study involving 400 pregnant women receiving antenatal care in Tamale Teaching Hospital was conducted. Using a semi-structured questionnaire and 24-h dietary recall, data were collected on socio-demographic characteristics, health practices, dietary diversity, anaemia knowledge and haemoglobin level of the women. Anaemia was defined as haemoglobin concentration less than 11 g/dl. Chi-square test and logistic regression analysis were used to identify the independent determinants of pregnancy anaemia.

Results
The mean age and haemoglobin of the women were 28.3 (±4.5) years and 10.81 (±1.41) g/dl respectively. About half of the women 50.8% [95% Confidence Interval (CI): 45.8–55.7] were anaemic and the prevalence of anaemia increased with pregnancy trimester. Among a host of socio-demographic, dietary, and preventive health service factors evaluated, the women’s knowledge on anaemia and pregnancy trimester at interview were the independent determinants of anaemia in pregnancy. Compared to women of the highest anaemia knowledge tertile, women belonging to the lowest (AOR = 2.63, 95% CI: 1.50–4.61) and middle (AOR = 1.92, 95% CI: 1.12–3.27) anaemia knowledge tertiles were about 3 and 2 times more likely to be anaemic respectively. Similarly, women in third trimester of pregnancy were about 4 times more likely to be anaemic compared to those in first trimester at the time of interview (AOR = 3.57, 95% CI: 1.91–6.67).

Conclusions
There is a high prevalence of anaemia, which increases with pregnancy trimester, in pregnant women attending ANC in a tertiary referral hospital in Northern Ghana. The women’s knowledge on anaemia and pregnancy trimester at the time of interview are associated with their anaemia status. The high prevalence of anaemia in pregnancy needs urgent intervention to prevent the occurrence of adverse maternal and neonatal outcomes. Education on anaemia should be intensified at ANCs.
Effects of psychosocial work factors on number of pain sites: The role of sleep quality as mediator
Authors: Vleeshouwers J. , Knardahl S. , Christensen J. O. 
Published: December 2019

Abstract
Background
Objective of the current study was to determine which of thirteen specific psychosocial work factors were related to number of musculoskeletal pain sites (NPS) prospectively over a two-year time span. Furthermore, the study aimed to explore possible mediation of these prospective relationships through sleep problems.

Methods
The study was a two-wave full panel study. Participants included 6277 employees of Norwegian companies, representing a wide range of occupations. Structural equation modelling was employed to analyze direct and indirect effects of thirteen specific psychological- and social work factors on sleep problems and NPS.

Results
Out of the thirteen work factors studied, positive challenges at work, role conflict, decision control, superior support, coworker support, empowering leadership, and social climate were statistically significantly related to subsequent NPS, both directly and indirectly through sleep quality. Sleep quality was related to NPS in all analyses. Most psychosocial work factors exhibited direct effects on either sleep or number of pain sites. Decision demands and control over work pacing were not statistically significantly related to sleep or pain.

Conclusion
In conclusion, the results suggested sleep quality to be involved in the mechanisms by which work affects the number of pain complaints employees experience.

Significance
Findings from this study suggest sleep may play a role in the complex mechanism from work stressors to musculoskeletal pain. Workplace interventions aiming to reduce musculoskeletal pain may wish to target work factors described in this study, as they affect sleep and may thereby increase number of musculoskeletal pain sites.