bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dynamic Performance Study of Six-Dimensional Dynamic Force Generator
Authors: Hongfei Cui , Quan Chen , Wei Li , Limeng Tan , Mingyan Jiang , Deqiang Song , Zheng Li 
Published: October 2019

Abstract
A six-dimensional dynamic force generating device is developed based on the dynamic performance calibration requirement of a six-dimensional force test platform based on the exciter force generating unit. The finite element software is used to perform modal analysis on the dynamic force generating device to obtain the natural frequency response of the device. Based on the finite element analysis results, the second-order transfer function at the sixth-order natural frequency point of the device is obtained, and the amplitude-phase frequency characteristic curve is obtained. Combined with the characteristic parameters of the exciter, the relationship curve between the excitation frequency and the excitation force under the influence of the natural frequency of the device is obtained. The comprehensive of finite element method and calculation results show that the designed dynamic force generating device can meet the requirements of use. According to the analysis results, it is found that the excitation capability can be maintained at a low frequency state to achieve high amplitude fixed frequency excitation, and low amplitude fixed frequency excitation is realized at a high frequency state.
A Test Scheme Design for High Speed Active Cabin Separation
Authors: Feng Wei , Li Changxun , Meng Fanwei , Chen Qiwei , Yi Wangmin , Zheng Shengyu , Wang Linzheng , Wang Chenxing , Zhang Lili 
Published: October 2019

Abstract
In Mars explorations, the EDL (Entry, Descent and Landing) process is autonomously controlled, called “black 7minutes”. In order to verify the EDL process of the Mars probe cabin (the heatshield facing the Mars surface and the aeroshell back to the surface of Mars) high speed separated, this paper proposes an active motor pull separation scheme and controlling method of axial force, normal force and torque multi-coupling, solves the technological problem of the force applied, followed and safe recycling cabin in short time and distance, establishes a test system and completed the separation test of the heatshield and the aeroshell by real product. The results show that the test success criteria are met and the test scheme is successful. This method and experimental system can be used not only in the separation experiment of Mars probe, but also in the separation or servo simulation of other detectors or general mechanisms, can be widely used or used for reference. This paper explains the general scheme and key technology, followed by other papers on ADAMS Simulation, influence on air-resistance and so on.
Test Research on Airdrop Shock Vibration of Armored Vehicles
Authors: Hou Jun-fang , Yu Guang-chun , Zhang Wei-hua , Wang He-ping , Liang Yuan-yuan 
Published: October 2019

Abstract
In view of the airdrop adaptability of a lightweight high-mobility wheeled armored vehicle, the shock vibration of the vehicle’s onboard electronic equipment under simulated airdrop was tested and the shock characteristic of the equipment was analyzed. The test results show that the onboard equipment of the airdrop vehicle is mainly subjected to three stages of shock vibration, which includes the crash of the lifting rope, shock of the cushion airbag and the rebound shock. The cushion airbags can effectively reduce the shock acceleration peak of the onboard electronic equipment of the light wheeled armored vehicle, and the shock peak of the onboard computer and power supply is about 9-10 g with the shock duration of 0.15-0.2 s. While compared with the shock of the base, the buffering effect of the isolators to the airdrop shock vibration is not satisfied. Resonances of the isolation system are caused by the airdrop shock and the shock peaks of the tested electronic equipment are higher than that of the base.
Research on the Effectiveness of Service Design Based on the Quantitative Method of Kansei Engineering—Taking the LANNA Coffee Service Process as an Example
Authors: Wang Zhengyu , Zhou Meiyu , Liu Xiangyu 
Published: October 2019

Abstract
The increasing enrichment of industrial products has made it difficult to meet the growing consumer demand for the material functions of products. This has caused the non-material or mental function of the product to be strengthened, promoted product design to gradually expand from the material dimension to the non-material service design, and accelerated the transformation of the manufacturing industry into a service-oriented product manufacturing. Service design has gradually become a new hot academic research field in product design. As a traditional industry, how to promote the transformation of coffee shop from “product” to “service” has become the research direction of this study. After investigation, we find some problems in coffee shop service, such as single focus, unbalanced proportion distribution of internal structure of service design, as well as vague and uncertain user demand. This paper attempts to use the forward quantitative inference method of Kansei Engineering to analyze consumers’ perceptual demands for coffee shop services through questionnaires, the overall process of service and the weight of service elements. We also try to set up the service elements and multivariate linear regression equation between the service effectiveness, put forward the service design effectiveness evaluation method, and on this basis, provide the analysis of the service system to serve the interests of the parties with complimentary method to make the adjustment and evaluation of service design more intuitive.
Pulling back singularities of codimension one objects
Authors: Giraldo Luis , Roeder Roland 
Published: October 2019

We prove that the preimage of a germ of a singular analytic hypersurface under a germ of a finite holomorphic map

g
:
(

C

n

,

0

)
→
(

C

n

,

0

)

g: (\mathbb {C}^n,\mathbf {0}) \rightarrow (\mathbb {C}^n, \mathbf {0})

is again singular. This provides a generalization of previous results of this nature by Ebenfelt-Rothschild [Comm. Anal. Geom. 15 (2007), no. 2, 491-507], Lebl [ArXiv preprint https://arxiv.orglabs/0812-2498], and Denkowski [Manuscripta Math. 149 (2016), no. 1–2, 83–91]. The same statement is proved for pullbacks of singular codimension one holomorphic foliations.
Reference values for handgrip strength: data from the TCLSIH cohort study
Authors: Wu Hongmei , Liu Mingyue , Zhang Qing , Liu Li , Meng Ge , Bao Xue , Gu Yeqing , Zhang Shunming , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Niu Kaijun 
Published: October 2019

Abstract

Background
although handgrip strength (HGS) is considered an excellent predictor of morbidity and mortality, there are few reference data available, especially across life from young to old populations.

Objective
to investigate the reference values and determinants for HGS in a large Chinese adult population.

Design
this cross-sectional study used data from the Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study ranging from 2013 to 2017.

Setting and subjects
in total, 37,707 Chinese adults aged 18–93 years with measures of HGS were included.

Methods
HGS was measured using a handheld digital dynamometer. The percentile distribution of HGS, as well as mean (standard deviation) values of HGS, was calculated according to sex and age categories. The Pearson’s or Spearman’s correlation coefficient and multiple linear regression were also used.

Results
the peak mean value of HGS was 45.2 ± 6.88 kg in men and 26.8 ± 4.65 kg in women. Different reference values for each sex and age category are present. The prevalence of low HGS was 7.69% in men and 6.46% in women. Multiple regression analysis showed that almost 72.5% of HGS variability can be explained by sex, age, height and weight.

Conclusions
the HGS reached peak at 40 years old, maintained or slightly lowered between ages 40 and50 and then start an accelerated decline after 50 years old. Reference values of HGS should be stratified by sex and age group. HGS variability can be largely explained by sex, age, height and weight.
Influenza Vaccine Effectiveness in the Inpatient Setting: Evaluation of Potential Bias in the Test-Negative Design by Use of Alternate Control Groups
Authors: Segaloff Hannah E , Cheng Bonnie , Miller Andrew V , Petrie Joshua G , Malosh Ryan E , Cheng Caroline , Lauring Adam S , Lamerato Lois E , Ferdinands Jill M , Monto Arnold S , Martin Emily T 
Published: October 2019

AbstractThe test-negative design is validated in outpatient, but not inpatient, studies of influenza vaccine effectiveness. The prevalence of chronic pulmonary disease among inpatients can lead to nonrepresentative controls. Test-negative design estimates are biased if vaccine administration is associated with incidence of noninfluenza viruses. We evaluated whether control group selection and effects of vaccination on noninfluenza viruses biased vaccine effectiveness in our study. Subjects were enrolled at the University of Michigan and Henry Ford hospitals during the 2014–2015 and 2015–2016 influenza seasons. Patients presenting with acute respiratory infection were enrolled and tested for respiratory viruses. Vaccine effectiveness was estimated using 3 control groups: negative for influenza, positive for other respiratory virus, and pan-negative individuals; it was also estimated for other common respiratory viruses. In 2014–2015, vaccine effectiveness was 41.1% (95% CI: 1.7, 64.7) using influenza-negative controls, 24.5% (95% CI: −42.6, 60.1) using controls positive for other virus, and 45.8% (95% CI: 5.7, 68.9) using pan-negative controls. In 2015–2016, vaccine effectiveness was 68.7% (95% CI: 44.6, 82.5) using influenza-negative controls, 63.1% (95% CI: 25.0, 82.2) using controls positive for other virus, and 71.1% (95% CI: 46.2, 84.8) using pan-negative controls. Vaccination did not alter odds of other respiratory viruses. Results support use of the test-negative design among inpatients.
Multiple founder events explain the genetic diversity and structure of the model allopolyploid grass Brachypodium hybridum in the Iberian Peninsula hotspot
Authors: Shiposha Valeriia , Marques Isabel , López-Alvarez Diana , Manzaneda Antonio J , Hernandez Pilar , Olonova Marina , Catalán Pilar 
Published: October 2019

Abstract

Background and Aims
It is accepted that contemporary allopolyploid species have originated recurrently, but very few cases have been documented using multiple natural formations of the same species. To extend our knowledge, we have investigated the multiple origins, genetic variation, and structure of the allotetraploid grass Brachypodium hybridum with respect to its progenitor diploid species B. distachyon (D genome) and B. stacei (S genome). For this, our primary focus is the Iberian Peninsula, an evolutionary hotspot for the genus Brachypodium.

Methods
We analysed 342 B. hybridum individuals from 36 populations using 10 nuclear SSR loci and two plastid loci. The B. hybridum genetic profiles were compared with those previously reported for B. stacei and B. distachyon. In addition, phylogenetic analysis of the plastid data was performed for a reduced subset of individuals.

Key Results
The nuclear SSR genetic analysis detected medium to high genetic diversity, with a strong south-to-north genetic structure cline, and a high selfing rate in B. hybridum. Comparative genetic analysis showed a close relatedness of current B. hybridum D allelic profiles with those of B. distachyon, but a lack of similarity with those of B. stacei, suggesting another B. stacei source for the B. hybridum S alleles. Plastid analysis detected three different bidirectional allopolyploidization events: two involved distinct B. distachyon-like ancestors and one involved a B. stacei-like ancestor. The Southeastern (SE) Iberian Peninsula B. hybridum populations were more genetically diverse and could have originated from at least two hybridization events whereas Northeaster-Northwestern (NE-NW) Iberian Peninsula B. hybridum populations were less diverse and may have derived from at least one hybridization event.

Conclusions
The genetic and evolutionary evidence support the plausible in situ origin of the SE and northern Iberian Peninsula B. hybridum allopolyploids from their respective local B. distachyon and unknown B. stacei ancestors. The untapped multiple origins and genetic variation detected in these B. hybridum populations opens the way to future evolutionary analysis of allopolyploid formation and genomic dominance and expression in the B. hybridum – B. distachyon – B. stacei grass model complex.
The Colorado Cognitive Assessment (CoCA): Development of an Advanced Neuropsychological Screening Tool
Authors: Gurnani Ashita S , Lin Shayne S-H , Gavett Brandon E 
Published: October 2019

Abstract

Objective
The Colorado Cognitive Assessment (CoCA) was designed to improve upon existing screening tests in a number of ways, including enhanced psychometric properties and minimization of bias across diverse groups. This paper describes the initial validation study of the CoCA, which seeks to describe the test; demonstrate its construct validity; measurement invariance to age, education, sex, and mood symptoms; and compare it to the Montreal Cognitive Assessment (MoCA).

Method
Participants included 151 older adults (MAge = 71.21, SD = 8.05) who were administered the CoCA, MoCA, Judgment test from the Neuropsychological Assessment Battery (NAB), 15-item version of the Geriatric Depression Scale (GDS-15), and 10-item version of the Geriatric Anxiety Scale (GAS-10).

Results
A single-factor confirmatory factor analysis model of the CoCA fit the data well, CFI = 0.955; RMSEA = 0.033. The CoCA factor score reliability was .84, compared to .74 for the MoCA. The CoCA had stronger disattenuated correlations with the MoCA (r = .79) and NAB Judgment (r = .47) and weaker correlations with the GDS-15 (r = −.36) and GAS-10 (r = −.15), supporting its construct validity. Finally, when analyzed using multiple-indicators, multiple-causes (MIMIC) modeling, the CoCA showed no evidence of measurement noninvariance, unlike the MoCA.

Conclusions
These results provide initial evidence to suggest that the CoCA is a valid cognitive screening tool that offers numerous advantages over the MoCA, including superior psychometric properties and measurement noninvariance. Additional validation and normative studies are warranted.
Serotonin differentially affects morph-specific behavior in divergent populations of a horned beetle
Authors: Newsom Keeley D , Moczek Armin P , Schwab Daniel B 
Published: October 2019

AbstractAssociations between animal weapons and corresponding aggressive behaviors are among the most characteristic features of species, yet at the same time their co-expression is itself often strongly dependent on context, such as male condition or population ecology. Yet the mechanisms that modulate associations between aggression, morphology, and biological context remain poorly understood. The biogenic amine serotonin has been shown to regulate a wide range of aggressive and morph-specific behaviors in diverse insect species. However, the extent to which serotonin may coordinate the expression of behavior with morphology across biological contexts remains unclear. In this study, we pharmacologically increased serotonin biosynthesis in males of the polyphenic beetle, Onthophagus taurus, and assessed how this manipulation affects both aggressive and non-aggressive behaviors in alternative fighter and sneaker morphs, as well as in males derived from two rapidly diverging populations characterized by disparate levels of competition for mates. We find (i) that enhancing serotonin biosynthesis increases most measures of aggressive behaviors, but influences only a subset of nonaggressive behaviors, (ii) that similar serotonin-mediated behavioral changes manifest in both morphs within populations more often than just a single morph, and (iii) that males derived from the two focal populations have diverged in their behavioral responsiveness to serotonin up-regulation. Collectively, our study suggests that serotonin signaling plays a critical role in the regulation of male behavior and its evolution, including in the context of rapid, short-term population divergence.
Inferring subgroup-specific driver genes from heterogeneous cancer samples via subspace learning with subgroup indication
Authors: Xi Jianing , Yuan Xiguo , Wang Minghui , Li Ao , Li Xuelong , Huang Qinghua 
Published: October 2019

Abstract

Motivation
Detecting driver genes from gene mutation data is a fundamental task for tumorigenesis research. Due to the fact that cancer is a heterogeneous disease with various subgroups, subgroup-specific driver genes are the key factors in the development of precision medicine for heterogeneous cancer. However, the existing driver gene detection methods are not designed to identify subgroup specificities of their detected driver genes, and therefore cannot indicate which group of patients is associated with the detected driver genes, which is difficult to provide specifically clinical guidance for individual patients.

Results
By incorporating the subspace learning framework, we propose a novel bioinformatics method called DriverSub, which can efficiently predict subgroup-specific driver genes in the situation where the subgroup annotations are not available. When evaluated by simulation datasets with known ground truth and compared with existing methods, DriverSub yields the best prediction of driver genes and the inference of their related subgroups. When we apply DriverSub on the mutation data of real heterogeneous cancers, we can observe that the predicted results of DriverSub are highly enriched for experimentally validated known driver genes. Moreover, the subgroups inferred by DriverSub are significantly associated with the annotated molecular subgroups, indicating its capability of predicting subgroup-specific driver genes.

Availability and implementation
The source code is publicly available at https://github.com/JianingXi/DriverSub.

Supplementary information
Supplementary data are available at Bioinformatics online.
Pentachloronitrobenzene alters progesterone production and primordial follicle recruitment in cultured granulosa cells and rat ovary†
Authors: Kuai Yanrong , Gao Xiaobo , Yang Huixia , Luo Haiyan , Xu Yang , Liu Chenchen , Yu Haiying , Wang Yihan , Zhang Chen , Ma Xu , Lu Cailing 
Published: October 2019

Abstract
Pentachloronitrobenzene (PCNB) is an organochlorine fungicide widely used for crop production and has become an environmental concern. Little is known about the effect of PCNB on ovarian steroidogenesis and follicular development. We found that PCNB stimulated Star expression and progesterone production in cultured rat granulosa cells in a dose-dependent manner. PCNB activated mitogen-activated protein kinase (MAPK3/1) extracellulat regulated kinase (ERK1/2), thus inhibition of either protein kinase A (PKA) or MAPK3/1 signaling pathway significantly attenuated progesterone biosynthesis caused by PCNB, suggesting that PCNB induced progesterone production by activating the cyclic adenosine monophosphate (cAMP/PKA) and MAPK3/1 signaling pathways. Further investigation demonstrated that PCNB induced Star expression and altered MAPK3/1 signaling in ovary tissues of immature SD rats treated with PCNB at the dose of 100, 200, or 300 mg/kg by daily gavage for 7 days, while serum progesterone level was dose-dependently decreased. We demonstrated that PCNB exposure accelerated the recruitment of primordial follicles into the growing follicle pool in ovary tissues, accompanied by increased levels of anti-Mullerian hormone (AMH) in both ovary tissues and serum. Taken together, our data demonstrate for the first time that PCNB stimulated Star expression, altered MAPK3/1 signaling and progesterone production in vivo and in vitro, and accelerated follicular development with a concomitant increase in AMH in ovary tissues and serum. Our findings provide novel insight into the toxicity of PCNB to animal ovary function.
Intersectional coproduction and infrastructural violence: experiences from Pakistan
Authors: Sawas Amiera , Castán Broto Vanesa , Anwar Nausheen H , Rehman Abdul 
Published: October 2019

Abstract
The delivery of projects for the coproduction of services raises multiple questions about how different structural barriers prevent and hinder the participation of various sectors of the population. Intersectionality theory provides a critical lens to examine the delivery of such coproduction projects to refine any strategies to include vulnerable perspectives or perspectives that get silenced by existing hierarchies. This paper presents an intersectionality-led analysis of the delivery of a project to improve public safety in Pakistan. The project mapped existing concerns about urban violence of different groups of the population. The project used a multilayered approach to facilitate the engagement of excluded views, both in the constitution of the research team and in the involvement of communities. An intersectionality framework is applied to analyse the deployment of the project in terms of design, innovation, planning, and signification. The analysis shows that there are limitations to how far coproduction exercises can challenge existing social structural barriers.
Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids
Authors: Brandt Nicola , Vierk Ricardo , Fester Lars , Anstötz Max , Zhou Lepu , Heilmann Lukas F , Kind Simon , Steffen Paul , Rune Gabriele M 
Published: October 2019

AbstractNumerous studies provide increasing evidence, which supports the ideas that every cell in the brain of males may differ from those in females due to differences in sex chromosome complement as well as in response to hormonal effects. In this study, we address the question as to whether actions of neurosteroids, thus steroids, which are synthesized and function within the brain, contribute to sex-specific hippocampal synaptic plasticity. We have previously shown that predominantly in the female hippocampus, does inhibition of the conversion of testosterone to estradiol affect synaptic transmission. In this study, we show that testosterone and its metabolite dihydrotestosterone are essential for hippocampal synaptic transmission specifically in males. This also holds true for the density of mushroom spines and of spine synapses. We obtained similar sex-dependent results using primary hippocampal cultures of male and female animals. Since these cultures originated from perinatal animals, our findings argue for sex-dependent differentiation of hippocampal neurons regarding their responsiveness to sex neurosteroids up to birth, which persist during adulthood. Hence, our in vitro findings may point to a developmental effect either directly induced by sex chromosomes or indirectly by fetal testosterone secretion during the perinatal critical period, when developmental sexual priming takes place.