bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDENTIFICATION OF ENVIRONMENTAL HEALTH AND SAFETY IN FACTORY OF HOSPITAL BEDS AT. X BEKASI
Authors: Wijaya Dwi Septian , Maulida Wilda 
Published: December 2019

In this globalization era, especially in the face of international trade competition then the principle of the application of health and safety are the main requirements that will greatly affect the investment value, quality,Â and quantity of products, the company's sustainability and competitiveness of a country. The purpose survey is to identify health and safety hazards which include chemical, physical, biological, ergonomic,Â and psychological hospital bed factory in PT. X Bekasi. The method used to survey and interview in the work unit welding, painting, assembling, and factory environments. Based on the survey results of the use of personal protective equipment (PPE) is pretty good and secure, while at 4 locations are all well qualified for occupational safety, health,Â and environment.
THE SURVEY OF SAFETY CULTURE IN RSUP Dr.KARIADI SEMARANG
Authors: Sulistyowati Elyana Sri , Muninggar Septi Dewi , Silalahi Verarica , Ariyanto Debi , Fatmawati Endang , Edhy Dharma Wahyu , Anandoyo Anggit 
Published: December 2019

Patient safety in hospitals is a crucial issue as significant medication errors occur in some countries. Patient safety incidence is inevitably related to safety culture implemented in hospitals. This survey aims to investigate the dimension of patient safety serving as a strong area and dimension for potential improvement. This study used a cross-sectional approach involving 361 subjects in all units in RSUP Dr.Â Kariadi. Findings are presented in graphs and frequency tables. This study found three dimensions of strength area involving management support regarding patient safety (92.93%), organizational learning-continuous improvement (91.73%), and unit cooperation (86.1%). Meanwhile, the area for potential improvement involving employment (45.43%), incidence report frequency (58.07%), and open communication (60.67%). Dimensions serving as strength areas need to be maintained while dimension for potential improvement need for support to cultivate patient safety culture in RSUP Dr.Â Kariadi.
HIV/AIDS PREVENTION BEHAVIOR IN THE COMMUNITY OF MEN WHO HAVE SEX WITH MEN AND INFLUENCING FACTORS
Authors: Sugiarto Sugiarto , Hanafi Pebriyaman , Berliana Novi 
Published: December 2019

HIV/AIDS has developed into a global health problem, including in Indonesia. The highest cumulative percentage of AIDS cases by way of transmission in Indonesia is through unprotected sex. Populations at high risk for HIV/AIDS transmission are gay (homosexual). This study aims to determine the description of HIV/AIDS prevention behavior and factors affecting theÂ community of men who have sex with men.Â This study uses a cross-sectional design. The research sample was 79 male sex men in the city of Jambi. The sampling technique was purposive aside. Data were collected by interview using a questionnaire. Data were analyzed statistically using the chi-square test.Â Of the 79 respondents whose behavior of HIV/AIDS prevention was not good enough as many as 40 respondents (50.6%). 34 respondents (43.0%) had poor knowledge. Respondents whose attitudes were not good were 41 respondents (51.9%). 42 respondents (53.2%) had poor motivation. Statistical test results show that there is no relationship of knowledge with p-value= 0.177, and there is a relationship between attitude and p-value= 0.005 and there is a relationship of motivation with p-value= 0.000 HIV/AIDS prevention behavior in theÂ community of men who have sex with men. The conclusion of the study is attitude and motivation are variables related to HIV/AIDS prevention behavior in the community of men who have sex with men.
EXAMINATION OF PULMONARY TUBERCULOSIS PATIENTS AT THE REGIONAL GENERAL HOSPITAL (RSUD) JAYAPURA
Authors: Sinaga Herlando 
Published: December 2019

TuberculosisÂ is a disease that is directlyÂ transmittedÂ andÂ caused by bacteria Mycobacterium tuberculosis. Tuberculosis is an infectious disease that still causesÂ high morbidity and mortality rates in the world. This research aims to determine the value of hemoglobin levels, platelet counts, erythrocytes, the number of neutrophils and Monocytes in positive patients with pulmonary tuberculosis who performed examinations at the Jayapura Regional General Hospital. This research was conducted for 1 month, starting from 1 May to 1 June 2018. This research is descriptive with a laboratory test approach. The population in this research included all patients who had positive pulmonary tuberculosis and the samples in this study were venous blood positive patients with pulmonary tuberculosis. The method used in this examination is flow cytometry using the hematology analyzer Sysmex XN-1000. The results of the research showed that from 20 samples, hemoglobin levels were obtained as much as 30% with normal hemoglobin levels and as much as 70% with low hemoglobin levels 70% of normal platelet value and as much as 30% high platelet count; 70% of the value of erythrocytes is normal and as much as 30% the amount of erythrocytes decreases; Neutrophils are as high as 55% while normal is 45%; and high monocytes as much as 25% and normal monocytes as much as 75%.
A methanolic extract of Trigonella foenum-graecum (fenugreek) seeds regulates markers of macrophage polarization.
Authors: Hassan Nurudeen , Withycombe Cathryn , Ahluwalia Maninder , Thomas Andrew , Morris Keith 
Published: December 2019

Background: Macrophages are key cellular mediators in diabetes-related inflammation. Molecular cues such as cytokines found in the tissue microenvironment regulates the polarization of macrophages into an M1 (pro-inflammatory) or M2 (immunoregulatory) phenotype. Recent evidence suggests that M1 macrophages in diabetic patients may contribute to the complications associated with the disease such as atherosclerosis. Trigonella foenum- graecum (Tfg: fenugreek) seeds have been used in traditional medicine in Asia, Africa and the Middle-East for their alleged anti-diabetic properties.Objective: To identify the molecular mechanism(s) through which Tfg seeds exert their effects, we investigated the role of a crude methanolic extract of Tfg (FME) seeds on macrophage polarization in vitro.Method: THP-1 macrophages (Mϕ) were treated with gBSA in the presence/absence of FME and the release and expression of M1 and M2 markers/cytokines were analysed. The role of FME on NF-κB activity was also explored using transfected HEK-293T cells.Results: This study found that the FME significantly (P<0.05) decreased gBSA-induced secretion of M1 cytokines (TNF-α, IL-1β, IL-6 and IL-8) in THP-1 Mϕ cells. In the presence of gBSA, FME also significantly increased the gene expression of the M2 marker Dectin-1, but had no effect on IL-10, IL-1Ra. FME also significantly decreased TNF-α induced NF-kB reporter activity.Conclusion: These results suggest that FME can regulate the expression of M1 and M2 markers in THP-1 Mϕ cells. This may be potentially through the modulation of NF-kB activity. Further work should be carried out to identify precise mechanism(s) involved in the effects of FME and Tfg seeds.Keywords: chronic inflammation, macrophage polarization, diabetes, glycated BSA, THP-1 cells, Trigonella foenum graecum, fenugreek seeds, NF-κB,
Correlation of pasting behaviors with total phenolic compounds and starch digestibility of indigenous pigmented rice grown in upper Northern Thailand
Authors: Ponjanta Jirapa , Chomsri Ni-orn , Meechoui Sawit 
Published: December 2019

Background: Thailand has one of the most important rice genetic resources with white, light brown, brown, red, and purple rice bran colors. The latter believed to have potential for health benefits due to their phenolic content. Recently researchers have indicated that starch digestive enzymes, including salivary and pancreatic α-amylases and α-glucosidases, can be inhibited by phenolic compounds. Although pasting properties of rice flour are key determinants of quality significantly impacting the final product texture, there is no in-depth study on their correlation with phenolic compound and starch digestibility. Methods: Rice flour from twelve varieties, three from each of five bran colors (white, brown, red, and purple), were evaluated for pasting properties (RVA-3D), total phenolic compounds, amylose content, resistant starch and estimated glycemic index. Simple correlation coefficients were calculated for the relationships between pasting properties (final viscosity, breakdown, setback and pasting temperature) and total phenolic compounds, resistant starch and estimated glycemic index.Results: Within each rice variety, red and purple pigmented flours had higher total phenolic compounds (TPC) and more resistant starch than that of white flours. The TPC and resistant starch content of the flours ranged between 7.83- 47.3 mg/L and 2.44–10.50% respectively, and producing 60-80 of estimated glycemic index. Viscosity behavior showed that pigmented with low amylose rice had lower viscosity temperature than that of pigmented with high amylose rice flour, but higher in peak viscosity. Correlation coefficients of pasting temperature, final viscosity, break down and setback with TCP was observed to be inversely related to glycemic index. However, it was positively correlated to the resistant starch and amylose content. Conclusions: Pigmented rice flour is a better source of TPC and resistant starch which in turn provides low glycemic index. This could help reduce the onset of type 2 diabetes and other related chronic diseases. In addition, this study provides impact of pasting behavior – TPC- resistant starch of rice flour relationships, which have important implication for utilization in food industry.Keywords: total phenolic compounds, amylose content, resistant starch, glycemic index
Nephroprotective effect of ethanolic leaf extract of Thaumatococcus danielli (benth.) in streptozotocin induced diabetic Rats
Authors: Olorunnisola Olubukola Sinbad , Adetutu Adewale , POPOOLA Rasaq B , Owoade Abiodun Olusoji , Adegbola Peter , Adesina Babatunde T 
Published: December 2019

Background: The leaves of Thaumatococcus danielli (Benth.) have been traditionally used in folk medicine to treat malaria in Nigeria. However, there is no report on whether these leaves contain Nephroprotective activity. Thus, the ethanol leaf extract was investigated for Nephron-protective activity in Streptozotocin induced diabetic rats.Methods: First, the LD50 of the leaf was determined using standard procedure. Rats were assigned to 5 groups (A-E) of five rats. Except for the control group, each group was made diabetic using Streptozotocin (65 mg/kg/b.wt. i p). The treated groups received 0.5 ml of glibenclamide (25mg/kg/b.wt, o.p), 250 and 500 mg/kg/b.wt, o.p of Thaumatococcus danielli respectively. After 14 days of treatment, animals were sacrificed under light anaesthesia. Data were expressed as Means ± S.D (n=5) and were analyzed using one-way ANOVA followed by Dunnet’s test, values were considered significant at p<0.05. Results: The plant showed a LD50 greater than 5000 mg/kg/b.wt in albino rats observed for 72 hours. A significant (p<0.05) decreased in serum Na+, Cl-, HCO-3, total protein, and an insignificant increase in K+, urea and creatinine level were observed in the diabetic group when compared with the normal group. Oral administration of plant extract and glibenclamide significantly (p<0.05) restored the electrolytes to near normal. Histological alterations such as glomerulonephritis, and tubules infiltration by inflammatory cells observed in diabetic control were also reversed.Conclusion: This study suggests renal protective ability of the plant against impairment due to hyperglycemia.Keywords: Streptozotocin, Thaumatococcus danielli, Nephroprotective, Glibenclamide, serum electrolytes.
Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults
Authors: Takara Tsuyoshi , Yamamoto Kazuo , Suzuki Naoko , Shimoda Hiroshi 
Published: December 2019

Background: The seaberry is a yellow berry cultivated in China, Northern Europe, and West Asian countries. Numerous biological activities of seaberries have been reported, and we recently found that ursolic acid and a flavonoid in seaberry extract (SBE) suppressed the contraction of bladder muscle specimens and collagen gel containing bladder smooth muscle cells. However, the influence of SBE on urinary problems of Japanese adults has not been investigated. Therefore, we conducted a clinical trial of SBE supplementation in Japanese subjects with mild urinary dysfunction.Methods: We examined the effect of SBE (200 or 400 mg daily) containing ursolic acid (0.18 or 0.36 mg) in a randomized double-blind placebo-controlled study. Capsules containing SBE or placebo were administered for 8 weeks to Japanese men and women with mild urinary dysfunction. After 4 and 8 weeks of treatment, urinary symptoms were evaluated by using the King’s Health Questionnaire (KHQ) and the overactive bladder syndrome score (OABSS).Results: There was significant improvement of the KHQ emotion domain score after intake of 400 mg/day of SBE for 8 weeks compared with placebo. The answers to “Does your bladder problem make you depressed?” and “Does your bladder problem make you feel bad about yourself?” were significantly improved by SBE (400 mg/day) at 8 weeks. In the OABSS, the item “How often do you have a sudden desire to urinate, which is difficult to defer?” was significantly improved by SBE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects SBE. Conclusions: Intake of SBE (400 mg/day for 8 weeks) improved several emotional parameters related to urinary dysfunction. SBE may be useful for reducing moderate urinary symptoms.Keywords: King’s health questionnaire; overactive bladder syndrome score; seaberry; ursolic acid; overactive bladder; urination; micturition
Health Benefits of Dietary Tree Peony Seed Oil in a High Fat Diet Hamster Model
Authors: Zheng Zhiqiang , Han Jigang , Mao Yingyi , Tang Xue , Guan Yan , Hu Yonghong 
Published: December 2019

Background: Tree peony (Paeonia ostii) seed oil is rich in different unsaturated fatty acids, including monounsaturated fatty acids (MUFA), n-3 and n-6 polyunsaturated fatty acids (PUFA). Health benefits of this edible plant oil as a whole are barely known yet. In this study, we experimentally investigated benefits of dietary tree peony seed oil (PSO) in dyslipidemia-associated metabolic diseases using a high fat diet hamster model.Methods: High fat diets (HFD) containing 15 % coconut oil (CO) or PSO were first developed based on the rodent chow diet. Fatty acid profiles of diets and red blood cells (RBC) from animals fed these diets for 8 weeks were analyzed and compared. Effects of these oil supplements on triglycerides and cholesterol levels were characterized. Benefits on fatty liver progress were also investigated in this animal model. Results: HFD fortified with 15% PSO was abundant in different unsaturated fatty acids, containing 40% α-linolenic acid, 27% linoleic acid and 23% oleic acid, respectively. Compared to the control group with 15% CO, animals with 15% PSO displayed dramatic alteration of in vivo fatty acid profile in RBC, featured with a significant increase in n-3 but no change in n-6 PUFA, resulting in decreased ratio of n-6 to n-3 PUFA. PSO intervention also remarkably reduced triglyceride levels in both blood and adipose tissues, while did not affect circulating cholesterol. Moreover, benefits on liver health were observed in the PSO group, evidenced with reduced hepatic steatosis and improved hepatic histology. Conclusion: These data altogether demonstrated multifaceted benefits of dietary PSO in reducing important risk factors of dyslipidemia-associated cardiovascular and liver diseases.Keywords: Peony seed oil, High fat diet, Triglyceride, Cholesterol, Hepatic steatosis
Omega3 Fatty Acids Intake Versus Diclofenac in Osteoarthritis Induced in Experimental rats
Authors: El-Seweidy Mohammed M. , Ali Sousou I. , Elsweify Sahar E. , Ali Abdelmoneim A. , Mashhour Mai M. 
Published: December 2019

Background: Osteoarthritis (OA) is a degenerative joint disease, characterized by abnormal remodeling pattern of joints driven by inflammatory mediators within the affected joints. Its symptoms are many like pain, stiffness, and decreased function.Objective: The present study mainly focused on the anti-inflammatory effect of omega 3 fatty acids (F.As) versus diclofenac, non-steroidal anti-inflammatory drug in OA induced in ratsDesign: Intraarticular injection of monosodiumiodoacetate (MIA) 24.6 mg/kg in 0.6 ml saline was used to induce OA. Diclofenacand omega-3 F. These were administered orally, daily for 21 days and after 24 hours of OA induction.Results: Osteoarthritis induction resulted in an increase in serum levels of IL-6 (479.5%), TNF-a(545.5%), and CRP (754.2%) along with IL-10 level decrease (70.3%) as compared to normal group. Diclofenac intake demonstrated significant increase of IL-6 (24.9%), CRP (88.6%), and TNF-a (25.2%) compared to the OA control group. Omega 3 FAs intake showed significant reduction in inflammatory markers along with IL-10 increase, in comparison to OA group. Both treatment demonstrated a significant increase in TIMP2 along with decreased MMP2 and MPO in comparison with OA control. Positive correlation of IL-6 with MPO (r = 0.7, P=0.002), and negative one with IL-10 (r = 0.9, p<0.0001) and TIMP2 (r = -0.5, p<0.008) was observed. Interleukin-10 was negatively correlated with MMP2 (r = - 0.5, p<0.007) and MPO (r = -0.8, p<0.0001).Conclusion: Data derived from biochemical and histopathological results, indicated that omega3 FAs may be expressed as a natural anti-inflammatory agent of a significant potential in OA with evident remarkable effect.Keywords: OA; omega3FAs; diclofenac; MMP2; TIMP2; MPO
Cytotoxic activity and anti-cancer potential of Ontario grown onion extracts against breast cancer cell lines
Authors: Fragis Meghan , Murayyan Abdulmonem I. , Neethirajan Suresh 
Published: December 2019

Background: Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths among Canadian women. Cancer management through changes in lifestyle, such as increased intake of foods rich in dietary flavonoids, have been shown to decrease the risk associated with breast, liver, colorectal, and upper-digestive cancers in epidemiologic studies. Onions are high in flavonoid content and one of the most common vegetables. Additionally, onions are used in most Canadian cuisines.Methods: We investigated the effect of five prominent Ontario grown onion (Stanley, Ruby Ring, LaSalle, Fortress, and Safrane) extracts on two subtypes of breast cancer cell lines: a triple negative breast cancer line MDA-MB-231 and an ER+ breast cancer line MCF-7.Results: These onion extracts elicited strong anti-proliferative, anti-migratory, and cytotoxic activities on both the cancer cell lines. Flavonoids present in these onion extracts induced apoptosis, cell cycle arrest in the G2/M phase, and a reduction in mitochondrial membrane potential at dose-dependent concentrations. Onion extracts were more effective against MDA-MB-231 compared to the MCF-7 cell line. Conclusion: In this study, we investigated the extracts synthesized from Ontario-grown onion varieties in inducing anti-migratory, cytostatic, and cytotoxic activities in two sub-types of human breast cancer cell lines. Anti-tumor activity of these extracts depends upon the varietal and can be formulated into nutraceuticals and functional foods for the wellbeing of cancer patients. Overall, the results suggest that onion extracts are a good source of flavonoids with anti-cancerous properties.Keywords: onion extracts; flavonoids; anti-proliferative; breast cancer; cytotoxic activity
Induction of apoptosis by fucoidan isolated from a traditional food, Saccharina longissima, in U937 human leukemia cells
Authors: Shimabukuro Junpei , Yogi Takuya , Nago Mariko , Teruya Takeshi , Konishi Teruko , Tako Masakuni 
Published: December 2019

Background: A brown seaweed, Saccharina longissima (Laminaria angustata var. longissima) has been consumed in Okinawa for 300 years. It is native to the southernmost part of Japan, in Okinawa, but grows on the Pacific coast (Kushiro and Nemuro) in Hokkaido in the northernmost part of Japan. Previously, we reported the structural characteristics from S. longissima. The fucoidan consisted of L-fucose, D-galactose, D-glucose, D-xylose, D-glucuronic acid, and sulfuric acid. This fucoidan activated the RAW 264.7 murine macrophage cell line. The aim of this study was to investigate the effects of a fucoidan isolated from Saccharina longissima on cell anti-proliferation and apoptosis in the U937 human leukemia monocyte lymphoma cell line. Methods: U937 cells were incubated with four fucoidan concentrations. The degree of apoptosis was determined using the APOPercentage APOPtosis assay, caspaer-3 activity assay and Western blotting analysis assay. Results: The treatment of cell with a fucoidan highly substituted with sulfate, in addition to L-fucose residues, inhibited cell growth. Apoptosis increased in U937 cells in a dose-dependent manner following the addition of fucoidan. However, the fucoidan did not induce apoptosis in the presence of caspase inhibitor (z-VAD-FMK).Conclusions: The fucoidan from Saccharina longissima induced apoptosis in U937 cells. Accordingly, the kelp containing this fucoidan may contribute to the observed longevity of the Okinawan population.Keywords: fucoidan, Saccharina longissimi, brown seaweed, traditional food, human leukemia cells, apoptosis
Analysis of factors governing dynamic stiffness index of medical compression bandages
Authors: Kumar Bipin , Das Apurba , Alagirusamy R. 
Published: December 2019

Objective: To identify and analyze the important factors which could influence the Dynamic Stiffness Index (DSI) of compression bandages. Methods: Using three commercially available bandages with different stiffnesses, their DSI was obtained using a prototype based on an artificial leg-segment model consisting of a wooden mannequin having a variable circumference. The effect on DSI of three major factors, bandage extensibility (ε), resting pressure (RP) and limb circumference (C) was studied. An N-way ANOVA for a fixed model was carried out to test the significance of the above major factors and their interaction effects on bandage DSI. Results: There were significant differences (p<0.05) between the mean DSI observed at different values of ε, RP and C. It was also found that some of the factors, ε and RP, and C and RP, interfere with each other and that their interaction effects also significantly affected the DSI (p<0.05). Conclusion: The above major factors have a deciding influence on the DSI of the compression bandages. Understanding the influence of these factors and the effect of their interactions on the DSI could help in pre-evaluating and comparing dynamic behaviors of different compression bandages during compression management.