bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediating effects of nursing organizational climate on the relationships between empathy and burnout among clinical nurses
Authors: Ren Ying , Song Huijuan , Li Shuang , Xiao Feng 
Published: September 2020

AbstractAims and objectivesTo investigate how nurses who worked in Guangdong province in China perceived empathy, nursing organization climate and burnout.DesignA cross‐sectional quantitative research design was used. We carried out the research in accordance with the Strengthening the Reporting of Observational studies in Epidemiology checklist.MethodsThe study was carried out from August–October of 2018 using a structured electronic questionnaire. A total of 965 participants were selected with convenience sampling in Guangdong province.ResultsA total of 786 valid questionnaires were collected in this study. The average burnout score of participants was 38.19 (SD 13.32) and 67.4% of them rated their burnout as more than 30 points, while 5.7% were higher than 60 points. The multi‐variable linear regression model explained 9.4% of the variance in burnout related to sociodemographic variables (p < 0.001). Empathy was significantly and positively associated with nursing organizational climate and emotional exhaustion while negatively associated with reduced personal accomplishment. In addition, nursing organizational climate mediated the relationship between empathy and reduced personal accomplishment.ConclusionOur findings suggest that both empathy and nursing organizational climate are protective factors that prevent burnout in this population. Managers can alleviate nurses’ burnout through developing empathy and improving the organizational climate.ImpactThis study demonstrates that empathy is not the cause of burnout; rather, it can prevent nurses from experiencing burnout. Nursing organizational climate is another protective factor that has a mediating effect on empathy and burnout. Improving empathy and nursing organizational climate could help reduce nurse burnout.
SATB2 is a novel biomarker and therapeutic target for cancer
Authors: Roy Sanjit K. , Shrivastava Anju , Srivastav Sudesh , Shankar Sharmila , Srivastava Rakesh K. 
Published: September 2020

AbstractSeveral studies have confirmed the involvement of cancer stem cells (CSC) in tumour progression, metastasis, drug resistance and cancer relapse. SATB2 (special AT‐rich binding protein‐2) acts as a transcriptional co‐factor and modulates chromatin architecture to regulate gene expression. The purpose of this review was to discuss the pathophysiological roles of SATB2 and assess whether it could be used as a therapeutic target for cancer. SATB2 modulated the expression of those genes which regulated pluripotency and self‐renewal. Overexpression of SATB2 gene in normal epithelial cells was shown to induce transformation, as a result transformed cells gained CSC’s characteristics by expressing stem cell markers and pluripotency maintaining factors, suggesting its role as an oncogene. In addition, SATB2 induced epithelial‐mesenchymal transition (EMT) and metastasis. Interestingly, the expression of SATB2 was positively correlated with the activation of β‐catenin/TCF‐LEF pathway. Furthermore, SATB2 silencing inhibited EMT and their positive regulators, and tumour growth, and suppressed the expression of stem cell markers, pluripotency maintaining factors, cell cycle and cell survival genes, and TCF/LEF targets. Based on the cancer genome atlas (TCGA) expression data and published papers, SATB2 alone or in combination with other proteins could be used a diagnostic biomarker for cancer. Although there is no pharmacological inhibitor of SATB2, studies using genetic approaches suggest that SATB2 could be a potential target for cancer treatment and prevention.
The long non‐coding RNA SNHG1 promotes bladder cancer progression by interacting with miR‐143‐3p and EZH2
Authors: Xiang Wei , Lyu Lei , Huang Tao , Zheng Fuxin , Yuan Jingdong , Zhang Chuanhua , Jiang Guosong 
Published: September 2020

AbstractThe long non‐coding RNA (lncRNA) SNHG1 has been shown to be implicated in the progression of multiple human carcinomas. Nevertheless, the biological functions and potential mechanism of SNHG1 in bladder cancer (BC) are uncharacterized. In the present study, SNHG1 was found to be substantially up‐regulated in BC tissues and cells and was intimately correlated with the TNM stage, lymphatic invasion, metastasis and recurrence‐free survival in BC patients. Down‐regulation of SNHG1 dramatically attenuated the proliferation, migration and invasion of BC cells, whereas the ectopic overexpression of SNHG1 had the opposite effects in vitro. The in vivo experimental results also indicated that SNHG1 down‐regulation hampered the tumour growth and metastasis of BC cells. Mechanistic investigations revealed that SNHG1 enhances HK2 expression by serving as an endogenous sponge to regulate miR‐143‐3p in the cytoplasm of BC cells. In the nucleus, SNHG1 could interact with EZH2 and regulate the histone methylation of the CDH1 promoter, altering the biological behaviours of BC cells. Overall, these findings elucidate an oncologic role of SNHG1 in BC and provide a new therapeutic strategy against BC.
Repair bond strength of dental computer‐aided design/computer‐aided manufactured ceramics after different surface treatments
Authors: AL‐Turki Lulwa , Merdad Yasser , Abuhaimed Tariq A. , Sabbahi Dania , Almarshadi Mazen , Aldabbagh Raghad 
Published: September 2020

AbstractObjectiveTo evaluate the microtensile bond strength of four dental computer‐aided design/computer‐aided manufactured (CAD/CAM) ceramics after application of four different surface treatments.Materials and methodsFour dental CAD/CAM ceramics were tested: feldspathic ceramic (VITABLOCKS‐Mark II), polymer‐infiltrated ceramic network (VITA ENAMIC), zirconia‐reinforced lithium silicate (VITA SUPRINITY), and yttria‐stabilized zirconia (VITA YZ T). Four surface treatments were applied: no treatment, 5% hydrofluoric acid‐etching, airborne particle abrasion, and tribochemical silica coating. The ceramic blocks were repaired with nanohybrid composite (Tetric N‐Collection). Sixteen test groups of 12 specimens were prepared. After thermocycling, microtensile bond testing was performed. The microtensile strengths values were statistically analyzed using two‐way analysis of variance and Tukey's post‐hoc test.ResultsRepaired feldspathic and resin polymer‐infiltrated ceramic network ceramics demonstrated superior microtensile bond strengths compared to zirconia‐reinforced lithium silicate and yttria‐stabilized zirconia. Etched feldspathic and polymer‐infiltrated ceramic network ceramics had higher bond strength than the untreated groups. Surface treatments did not affect the bond strength of zirconia‐reinforced lithium silicate and yttria‐stabilized zirconia with the exception of etching, which reduced the bond strength of yttria‐stabilized zirconia.ConclusionFeldspathic ceramic and polymer‐infiltrated ceramic network were repaired with dental composite after surface etching with hydrofluoric acid. Repair of zirconia‐reinforced lithium silicate and yttria‐stabilized zirconia did not demonstrate promising results.Clinical significanceRepair of feldspathic ceramic and polymer‐infiltrated ceramic network restorations may be a cost‐effective means to promote the longevity of dental restorations. However, zirconia and zirconia‐reinforced lithium disilicate restorations do not offer such an option.
The epidemiological characteristics of thromboembolism related to oral contraceptives in Japan: Results of a national survey
Authors: Sugiura Kazuko , Kobayashi Takao , Ojima Toshiyuki 
Published: September 2020

AbstractAimThe aim of this study was to reveal the epidemiological characteristics of thromboembolism related to combined oral contraceptives (COCs) in Japan.MethodsA survey of confirmed thromboembolism patients among Japanese COC users was conducted at randomly selected hospitals from across Japan. The survey examined six types of venous thromboembolism (VTE) and arterial thromboembolism (ATE) in all COC users: pulmonary embolism, deep vein thrombosis, other venous thrombosis, cerebral infarction, myocardial infarction, and other arterial thrombosis. The survey covered 5 years from 2009 to 2013. This study was approved in an ethical review by Hamamatsu University School of Medicine.ResultsFour hundred and twenty‐five cases clearly related to COCs were analyzed. The annual estimated incidence rates per 10 000 person‐years of VTE, ATE and all thromboembolisms in all COC users were 1.17, 0.33 and 1.50, respectively. The incidence of thromboembolism was 35.2% within 30 days from the start of COCs, 53.8% within 90 days, 66.9% within 180 days and 78.2% within 360 days regardless of progestin type. Age adjusted odds ratios in the obese and underweight groups were 2.33 and 0.98 for overall thromboembolism, 2.59 and 0.77 for VTE, and 1.11 and 1.28 for ATE compared with the standard group, respectively. Odds ratios for thromboembolism in non‐O blood groups were 1.89 for overall thromboembolism, 2.16 for VTE, and 1.35 for ATE, when compared with the O blood group.ConclusionThe epidemiological characteristics of COC‐related thromboembolisms were revealed in this national survey covering the years from 2009 to 2013.
How do culinary methods affect quality and oral processing characteristics of pork ham?
Authors: Djekic Ilija , Ilic Jovan , Lorenzo Jose M. , Tomasevic Igor 
Published: September 2020

AbstractThe influences of three different culinary methods: cooking, sous vide and grilling were studied with regards to quality and oral processing characteristics of pork ham. Besides instrumental analysis of color and textural properties of pork ham, sensory panel with 12 trained panelists participated in temporal dominance of sensations, oral processing analysis, boluses collection, particle size distribution analysis, and saliva incorporation. The results revealed that number of chews, mastication time and saliva incorporation are correlated with textural properties and cooking losses. In‐mouth sensation was intertwined with juiciness, fibrousness and firmness depending on the culinary methods. Cooked pork ham showed highest results for hardness and cooking loss. Firmness and fibrousness were dominant sensory attributes. Sous‐vide results show that firmness and juiciness dominated during the first third of consumption time. This corresponds with textural values for lowest values for hardness and cooking, number of chews and total exposure time. Sous‐vide also resulted in lower values for number of chews and total exposure time associated with oral processing.
Comparative analysis of the effect of PO administered acid suppressants on gastric pH in healthy cats
Authors: Ryan Phillip , Odunayo Adesola , Price Josh , Hecht Silke , Hillsman Shanna , Galyon Gina , Steiner Joerg , Tolbert M. Katherine 
Published: September 2020

AbstractBackgroundProton pump inhibitors (PPIs) are among the most commonly prescribed medications for esophagitis and upper gastrointestinal erosion and ulceration in cats. Newer PPIs such as lansoprazole and esomeprazole are believed to be effective in cats, but the effect of many of these PPIs on gastric pH in cats has not been explored.Hypothesis/ObjectivesTo evaluate the efficacy of PO esomeprazole, dexlansoprazole, and lansoprazole on intragastric pH in healthy cats. We hypothesized that esomeprazole and lansoprazole would provide superior acid suppression compared to dexlansoprazole and reach pH goals extrapolated from people for the treatment of esophagitis and duodenal ulceration.AnimalsTwelve healthy research cats.MethodsRandomized, 3‐way crossover study. Cats were given esomeprazole and lansoprazole at a dosage of 1 mg/kg PO q12h or dexlansoprazole at 6 mg/kg PO q12h. Intragastric pH was recorded at baseline and for 4 days of treatment. Mean pH and the mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were compared among and within treatment groups.ResultsCats treated with lansoprazole had a lower MPT ± SD of intragastric pH ≥3 (8.8 ± 6.8%) and mean ± SD pH (1.6 ± 0.5) than did cats treated with dexlansoprazole (41.2 ± 34.6% and 3.11 ± 1.6, respectively) or esomeprazole (54 ± 33.8% and 4.1 ± 3.9, respectively;P ≤ .04). Esomeprazole was the only treatment that achieved the goals defined for people for the treatment of duodenal ulceration by Day 4 of treatment (MPT ± SD of intragastric pH ≥4 of 77.1 ± 29.2%).Conclusions and Clinical ImportanceOrally administered esomeprazole might be a superior acid suppressant in cats compared to PO lansoprazole or dexlansoprazole.
Effect of low levels of fumonisin contamination on gilthead seabream (Sparus aurata)
Authors: Gonçalves Rui A. , Dias Jorge , Schatzmayr Dian 
Published: September 2020

AbstractUse of plant‐based ingredients in aquafeeds, especially for carnivorous species, is likely to increase in view of concerns regaridng the sustainability, price, and availability of fishmeal. As mycotoxins are a common problem associated with the use of plant ingredients, this study was undertaken to evaluate the effect of two levels of fumonisins (168 μg/kg feed and 333 μg/kg) and compared with 0μg/kg (the Control diet) for total growth, whole‐body nutrient retention, liver enzyme activity, and several plasma humoral parameters in juvenile gilthead seabream, Sparus aurata. Results suggest that diets contaminated with fumonisins can be detrimental to the growth performance of seabream. Fumonisin levels as low as 168 μg/kg feed had a significant impact on final body weight, feed conversion ratio, and protein efficiency ratio. Fumonisins also reduced fat and energy retention and disrupted the respiratory burst in circulating leukocytes. Fumonisin levels at 333 μg/kg feed increased these detrimental effects, clearly demonstrating a dose–response relationship. These results highlight the possible need to re‐evaluate the European Commission guidance value for fumonisins (FB1 + FB2) in complementary and complete feedstuffs for fish of 10,000 μg/kg, which might be too high for certain species, such as seabream.
Three decades post‐reforestation has not led to the reassembly of arbuscular mycorrhizal fungal communities associated with remnant primary forests
Authors: Wall Christopher B. , Egan Cameron P. , Swift Sean I. O. , Hynson Nicole A. 
Published: September 2020

AbstractThe negative effects of deforestation can potentially be ameliorated through ecological restoration. However, reforestation alone may not reassemble the same ecological communities or functions as primary forests. In part, this failure may be owed to forest ecosystems inherently involving complex interactions among guilds of organisms. Plants, which structure forest food webs, rely on intimate associations with symbiotic microbes such as root‐inhabiting mycorrhizal fungi. Here, we leverage a large‐scale reforestation project on Hawai‘i Island underway for over three decades to assess whether arbuscular mycorrhizal (AM) fungal communities have concurrently been restored. The reference ecosystem for this restoration project is a remnant montane native Hawaiian forest that provides critical habitat for endangered birds. We sampled soils from 12 plots within remnant and restored forest patches and characterized AM fungal communities using high‐throughput amplicon sequencing. While some AM fungal community metrics were comparable between remnant and restored forest (e.g. species richness), other key characteristics were not. Specifically, community membership and the identity of AM fungal keystone species differed between the two habitat types, as well as the primary environmental factors influencing community composition. Remnant forest AM fungal communities were strongly associated with soil chemical properties, especially pH, while restored forest communities were influenced by the spatial proximity to remnant forests. We posit that combined, these differences in soil AM fungal communities could be negatively affecting the recruitment of native plant hosts and that future restoration efforts should consider plant–microbe interactions as an important facet of forest health.
Evaluation of two lateral flow assays in BAL fluids for the detection of invasive pulmonary aspergillosis: A retrospective two‐centre study
Authors: Scharmann Ulrike , Verhasselt Hedda Luise , Kirchhoff Lisa , Buer Jan , Rath Peter‐Michael , Steinmann Joerg , Ziegler Katharina 
Published: September 2020

SummaryBackgroundCommonly, the application of radiological and clinical criteria and the determination of galactomannan (GM) in respiratory samples are used as a diagnostic tool for the detection of invasive pulmonary aspergillosis (IPA).Materials/methodsIn this study, two lateral flow assays, OLM Aspergillus lateral flow device (LFD) and IMMY sōna Aspergillus Galactomannan lateral flow assay (LFA), were evaluated at two tertiary hospitals in Germany. A total of 200 bronchoalveolar lavage (BAL) samples from patients with suspicion of IPA were analysed retrospectively. LFD and LFA were evaluated against four different criteria: Blot, EORTC/MSG, Schauwvlieghe and extended Blot criteria and additionally against GM.ResultsThe evaluation of four algorithms for the diagnosis of IPA showed that there exist good diagnostic tools to rule out an IPA even before results of Aspergillus culture are available. Sensitivities and negative predictive values are generally higher for the LFA than for the LFD in all four criteria. Specificity and positive predictive values varied depending on the classification criteria.The total agreement between the GM and the LFA cube reader (cut‐off = 1) was 84%. The correlation between the GM and LFA was calculated with r = 0.8.ConclusionThe here presented data indicate that a negative LFA result in BAL fluid can reliable rule out an IPA in a heterogeneous group of ICU patients based on the original Blot criteria. LFA seems to be a promising immunochromatographic test exhibiting a good agreement with positive GM values.
Environmental pollution in Asian economies: Does the industrialisation matter?
Authors: Zafar Ayaz , Ullah Sana , Majeed Muhammad Tariq , Yasmeen Rizwana 
Published: September 2020

AbstractIndustrialisation is a significant part of any country's economic development. This study discusses the relationship between industrialisation and carbon dioxide emissions for Asian economies. The industrialisation has a major impact on carbon emissions, but its relationship with the environment differs in various regions of Asia. The empirical results are obtained by models of panel regression, which divide a balanced panel dataset of 46 countries into five groups depending on their subregions over the period 1991–2017. The tests of panel cointegration estimation found a majority of the cointegrated variables and verified the long‐run relationship between the variables. The long‐run coefficients are estimated using a fully modified ordinary least‐squares (FMOLS) method, and results conclude that industrialisation has a positive impact on the carbon dioxide emissions in the long run. These findings reveal that various industrialisation development strategies should be pursued in a bid to reduce emissions, depending on the levels of economic growth. Based on the findings, some policy suggestions are proposed for Asian economies.
Reading with central vision loss: binocular summation and inhibition
Authors: Silvestri Valeria , Sasso Paola , Piscopo Paola , Amore Filippo , Rizzo Stanislao , Devenyi Robert G , Tarita‐Nistor Luminita 
Published: September 2020

AbstractPurposeThere are conflicting reports as to whether there is a binocular advantage or disadvantage when reading with central vision loss. This study examined binocular reading summation in patients with macular degeneration.MethodsSeventy‐one patients with bilateral central vision loss [mean age: 63 (S.D. = 21) years] participated. Reading performances during binocular and monocular viewing with the better eye (i.e., the eye with the best monocular visual acuity) were evaluated using different versions of the Italian MNREAD reading chart (www.precision‐vision.com). Fixation stability and preferred retinal loci (PRLs) were recorded monocularly for each eye. The overall sample was split into inhibition, equality, and summation groups based on the binocular ratio (i.e., binocular/monocular) of the maximum reading speed.Results41% of patients experienced binocular inhibition, 42% summation, and 17% equality. Binocular reading speed of the inhibition group was approximately 30 words per minute slower than those of the equality and summation groups, although the inhibition group had the best visual acuity. These patients generally had monocular PRLs in non‐corresponding locations temporal or nasal to the scotoma, had the largest interocular acuity difference and lacked residual stereopsis. The three groups did not differ in fixational control, contrast sensitivity or critical print size.ConclusionsEqual proportions of patients with central vision loss show binocular reading summation and inhibition. Patients with binocular reading inhibition have poorer reading performance and different clinical characteristics than those with binocular reading summation and equality.
Innovative transcriptome‐based genotyping highlights environmentally responsive genes for phenology, growth and yield in a non‐model grain legume
Authors: Plewiński Piotr , Ćwiek‐Kupczyńska Hanna , Rudy Elżbieta , Bielski Wojciech , Rychel‐Bielska Sandra , Stawiński Stanisław , Barzyk Paweł , Krajewski Paweł , Naganowska Barbara , Wolko Bogdan , Książkiewicz Michał 
Published: September 2020

AbstractThe narrow‐leafed lupin, Lupinus angustifolius L., is a grain legume crop, cultivated both as a green manure and as a source of protein for animal feed and human food production. During its domestication process, numerous agronomic traits were improved, however, only two trait‐related genes were identified hitherto, both by linkage mapping. Genome‐wide association studies (GWAS), exploiting genomic sequencing, did not select any novel candidate gene. In the present study, an innovative method of 3′‐end reduced representation transcriptomic profiling, a massive analysis of cDNA ends, has been used for genotyping of 126 L. angustifolius lines surveyed by field phenotyping. Significant genotype × environment interactions were identified for all phenology and yield traits analysed. Principal component analysis of population structure evidenced European domestication bottlenecks, visualized by clustering of breeding materials and cultivars. GWAS provided contribution towards deciphering vernalization pathway in legumes, and, apart from highlighting known domestication loci (Ku/Julius and mol), designated novel candidate genes for L. angustifolius traits. Early phenology was associated with genes from vernalization, cold‐responsiveness and phosphatidylinositol signalling pathways whereas high yield with genes controlling photosynthesis performance and abiotic stress (drought or heat) tolerance. PCR‐based toolbox was developed and validated to enable tracking desired alleles in marker‐assisted selection. Narrow‐leafed lupin was genotyped with an innovative method of transcriptome profiling and phenotyped for phenology, growth and yield traits in field. Early phenology was found associated with genes from cold‐response, vernalization and phosphatidylinositol signalling pathways, whereas high yield with genes running photosystem II and drought or heat stress response. Key loci were supplied with PCR‐based toolbox for marker‐assisted selection.