bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY
Authors: Yang Haojun , Liu Hanyang , Jiao YuWen , Qian Jun 
Published: June 2020

Background:
G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic
diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass
(GBP).

Methods:
Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the
obesity model. GBP was performed. The changes in body weight and food intake were measured. The
levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover,
the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were
evaluated by ELISA.

Results:
The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not
tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly
affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared
with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly
affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of
PYY were significantly increased in L-cells tgr5+/+ (p<0.05).

Conclusion:
Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines,
and increased the levels of PYY, which further reduced food intake and decreased the body weight.
Post-Operative Evaluation of the Intra-Oral Buccal Fat Pad Removal Technique: A Prospective Study
Authors: Roman-Torres Caio , Domingues Nilton R.A.P. , Pimentel Angelica C. , Marão Heloisa F. , Sendyk Wilson R. 
Published: June 2020

Background:
In recent years, the number of procedures for buccal fat pad removal has increased. In cases of thinning of the face, bite injuries or bruxism, partial removal of the corpuscle is performed, always taking into account facial harmonization.

Objective:
The aim of the present study was to demonstrate the post-operative procedure of the removal of the BFP by pain parameters, mouth opening and presence of edema. This longitudinal cohort study was registered in clinical trials and all participants had access to the informed consent form.

Methods:
Forty BFP removal surgeries were performed with the technique of intraoral access. After the bichectomy procedure, the individuals were followed for 4, 7, 10, 15, 30, and 90 days. Visual pain scale, mouth opening measurements and clinical visual assessment were performed at all times.

Results:
We observed that the presence of edema and limited mouth opening for about 15 days were the changes most commonly found in surgeries performed. The results showed a significant decrease in painful symptoms after 15 days, regarding mouth opening, the results showed a return to normal levels after 30 days (p <0.05), the presence of edema ceased after 15 days.

Conclusion:
We conclude that the BFP removal, when performed following a precise indication, properly and with the recommendations of post-operative care, followed correctly, promotes limitation in mouth opening and painful symptoms by 15 days.
The procedure is becoming a new area for the dental surgeon, who can perform the procedure safely, reliably and with aesthetic and therapeutic results.
Acaulospora longula Increases the Content of Phenolic Compounds and Antioxidant Activity in Fruits of Libidibia ferrea
Authors: dos Santos Emanuela L. , V. da Silva Wliana A. , Ferreira Magda R. A. , Soares Luiz Alberto , Sampaio Everardo V. de Sá Barretto , A. da Silva Francineyde , B. da Silva Fábio S. 
Published: June 2020

Background:
Several countries have made an association that how conventional and traditional medicines support the rational use of medicinal plants in different treatments. Brazil has stimulated the cultivation of and the development of the studies of Libidibia ferrea, a plant with medicinal properties, which are provided by the presence of bioactive compounds in its several parts, such as fruits. The synthesis of these biomolecules may increase with Arbuscular Mycorrhizal Fungi (AMF) inoculation. However, there have been no previous reports about the optimization in the production of biomolecules in the fruits of mycorrhizal L. ferrea.

Objective:
The aim of this study was to define the potential advantages of inoculation with AMF by increasing the production of biomolecules and antioxidant activity in fruits of mycorrhizal L. ferrea.

Methods:
The phytochemical and mycorrhizal analyses occurred after 32 months of transplanting to the field and the plants were inoculated or not with Acaulospora longula, Claroideoglomus etunicatum and Gigaspora albida and then by transplanting the seedlings to the field.

Results:
Compared to those from the control treatment, the concentration of phenols and tannins in the fruits of L. ferrea inoculated with A. longula increased 26.4% and 39.8% (p <0.05), respectively. The fruits also had higher antioxidant activity. In contrast, the concentration of phosphorus in the fruits of L. ferrea inoculated with A. longula and C. etunicatum was not incresead. Because the concentration of phosphorus in fruits was verified in this study.

Conclusion:
Mycorrhization increased the concentration of biocompounds and antioxidant activity in the fruits of L. ferrea, which is of great interest to the herbal medicine industry.
Analysis of Potential Interaction between Antiretrovirals and Comorbid Medications of HIV Patients at a Top Referral Hospital in Indonesia
Authors: Nafrialdi Nafrialdi , Moulita Syelvia , Instiaty Instiaty , Yunihastuti Evy 
Published: June 2020

Background:
HIV/AIDS usually present with comorbid diseases such as tuberculosis, pneumonia, toxoplasmosis, fungal infections, etc., that need multiple medications. Potential interaction between ARV and comorbid drugs is unavoidable.

Objective:
This study aimed to investigate the potential interaction between ARV drugs and medications used to treat comorbid diseases among HIV patients at the Dr. Cipto Mangunkusumo Hospital, Jakarta.

Methods:
This was an observational study using medical record data of 121 HIV/AIDS patients treated at the CM Hospital between January 2016 and July 2017. Potential interaction was classified as “major” if it could lead to increase or decrease of plasma drug levels which potentially result in either drug toxicity or treatment failure, or clinically significant harm to the patient; “moderate” if the interaction is not major, but with the recommendation of close monitoring. National, European, Australian, and Liverpool iChart guidelines were used for the classification of drug interactions.

Results:
Major interactions were noted in 17 (14.05%)patients. Fourteen of them received rifampicin, which potentially decreases plasma level of nevirapine (9 patients), rilpivirine (1 patient), and lopinavir/ritonavir (4 patients). Potential increase of ARV level was found in 3 patients involving interaction between voriconazole-efavirenz (2) and omeprazole-rilpivirine (1). Moderate interaction with the potential decrease of ARV level occurred in 46 patients (38.01%); consisting of a combination of rifampicin with efavirenz (38 pts), rifampicin with zidovudine (6 pts), and phenytoin with efavirenz or nevirapine (2 patients).

Conclusion:
Potential major interaction occurred in 17 (14.05%), which mostly attributed to rifampicin use; while moderate interaction occurred in 46 (38.01%) of patients. Although no serious adverse event was observed in this study, special care should be taken when the drugs with potential major interaction are to be administered
The Role of Nano-ophthalmology in Treating Dry Eye Disease
Authors: Natesan Subramanian , Boddu Sai H.S. , Krishnaswami Venkateshwaran , Shahwan Moyad 
Published: June 2020

:
Dry eye disease (DED) is a common multifactorial disease linked to the tears/ocular
surface leading to eye discomfort, ocular surface damage, and visual disturbance. Antiinflammatory
agents (steroids and cyclosporine A), hormonal therapy, antibiotics, nerve growth
factors, essential fatty acids are used as treatment options of DED. Current therapies attempt to
reduce the ocular discomfort by producing lubrication and stimulating gland/nerve(s) associated
with tear production, without providing a permanent cure for dry eye. Nanocarrier systems
show a great promise to revolutionize drug delivery in DED, offering many advantages such as
site specific and sustained delivery of therapeutic agents. This review presents an overview,
pathophysiology, prevalence and etiology of DED, with an emphasis on preclinical and clinical
studies involving the use of nanocarrier systems in treating DED.

Lay Summary:
Lay Summary: Dry eye disease (DED) is a multifactorial disease associated with tear deficiency
or excessive tear evaporation. There are several review articles that summarize DED, disease
symptoms, causes and treatment approaches. Nanocarrier systems show a great promise to
revolutionize drug delivery in DED, offering many advantages such as site specific and sustained
delivery of therapeutic agents. Very few review articles summarize the findings on the
use of nanotherapeutics in DED. In this review, we have exclusively discussed the preclinical
and clinical studies of nanotherapeutics in DED therapy. This information will be attractive to
both academic and pharmaceutical industry researchers working in DED therapeutics.
Intravenous Oxytocin versus Intramuscular Oxytocin for the Management of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis
Authors: Ebada Mahmoud Ahmed , Elmatboly Abdelmagid M. , Baligh Galal 
Published: June 2020

Background:
Postpartum Hemorrhage (PPH) is one of the primary causes of maternal
mortality and morbidity during the third stage of labor. Oxytocin is the gold standard uterotonic
agent for the prevention of PPH.

Objective:
We aimed to compare the efficacy of oxytocin administered Intramuscularly (IM) or
Intravenously (IV) for the preventive management of PPH.

Methods:
We searched six databases for relevant clinical trials evaluating the administration of oxytocin
for the prevention against PPH through July 2019. Data on blood loss, PPH (≥500 ml), severe
PPH (≥1000 ml), blood transfusion, the change in hemoglobin, the use of additional uterotonics, and
the incidence of retained placenta were extracted and pooled in a meta-analysis model using
RevMan version 5.3.

Results:
Seven studies with a total of 6996 participants were included. IM oxytocin group was
associated with higher incidence rates of PPH (≥500 ml) (RR=1.35; p=0.003), severe PPH (≥1000
ml) (RR=1.58; p=0.04), and blood transfusion (RR=2.43; p=0.005). In terms of blood loss, the IV
route was superior to the IM route (SMD= 0.15; p=0.00001). However, we observed no statistically
significant difference between the two routes regarding the change in Hb (SMD=-0.02; p=0.72) and
the use of additional uterotonics (RR=0.96, p= 0.94).

Conclusion:
IV oxytocin infusion is maybe superior to IM injection for the management of PPH.
Further studies with larger sample sizes are still needed to support these findings.
Relación entre calidad de escritura y rasgos lingüístico-discursivos en las introducciones de los trabajos finales de grado de ingenierı́a civil informática
Authors: Lillo Fuentes Fernando Gabriel , Venegas René 
Published: June 2020

En este artı́culo nos proponemos relacionar la calidad de la escritura con un amplio conjunto de rasgos lingüı́sticos y discursivos presentes en introducciones de los trabajos finales de grado de Ingenierı́a civil informática.
Para ello se evaluaron 101 introducciones, utilizando una rúbrica diseñada para este efecto. Se realiza un estudio correlacional entre la evaluación de la calidad y 203 variables léxicas, de extensión, sintácticas y discursivas. Luego, se realizó un análisis de regresión lineal con el fin de identificar variables predictoras de la calidad de las introducciones.
Entre nuestros hallazgos destacamos que la extensión (promedio de palabras) presenta una relación negativa fuerte con la calidad de la introducción, a su vez el uso de conectores conclusivos y la complejidad sintáctica se correlacionan de manera positiva con la calidad de las introducciones. Ası́ también, el cumplimiento de propósitos comunicativos, en particular la indicación del vacı́o, presenta correlaciones positivas medias con la calidad del escrito. Con el análisis de regresión se pudo identificar que las tres primeras variables tienen valores estadı́sticos significativos para predecir las calidad de la introducción de acuerdo a los valores promedio de evaluación asignada por los evaluadores. Estos resultados son de interés para aplicaciones computacionales de apoyo a la escritura académica.
Periodização automática
Authors: Santos Diana , Pires Emanoel , Freitas Cláudia , Fuão Rebeca Schumacher , Lopes João Marques 
Published: June 2020

Neste artigo usamos um conjunto de características sintático-semânticas da língua portuguesa para classificar em períodos literários dois conjuntos de obras. Em que medida tais características são capazes de refletir distinções relevantes no âmbito dos estudos literários é uma das questões que pretendemos investigar.
O primeiro grupo de obras corresponde à replicação do trabalho relatado em 2009 por Barufaldi et al., que usaram métodos de compressão de dados sobre uma série de obras brasileiras classificadas em quatro períodos literários: barroco, arcadismo, romantismo e realismo, desde o Padre António Vieira até Raul Pompéia, contabilizando 15 autores diferentes e totalizando 37 obras.
O segundo grupo inclui muito mais obras (192), tanto portuguesas como brasileiras, mas apenas integra romances ou novelas publicadas no período de 1840 a 1919. As escolas literárias escolhidas foram o realismo, o romantismo, o simbolismo, o naturalismo, o decadentismo e o modernismo, mas, ao contrário da classificação anterior, permitimos que uma mesma obra pertença a várias escolas.
Usamos técnicas de classificação em R para a primeira tarefa, e análise de correspondências para a segunda. Também aplicamos técnicas de modelos de tópicos à segunda coleção para ver se é possível obter tópicos representativos de escolas literárias diferentes.
Efficiency of organ-saving operations conducted about early postpartum uterine bleeding and their influence on the quality of women’s lives
Authors: Khayrullina G, R. , Druzhkova E. B. , Fatkullina L. S. , Fatkullin F. I. , Budyak Y. V. 
Published: June 2020

Objective: to study the long-term eff ects of massive blood loss in parturition and the early postpartum period on the reproductive function and psychological status of women.Materials and methods: the study included 49 women who were imposed compressive hemostatic sutures in the uterus due to the development of early postpartum hemorrhage. It was carried out a retrospectiveanalysis of medical records, prospective survey - 46 women, tested scales postpartum depression - 46 women and assessment of quality of life using the SF-36 scales - 36 women.Results: the effi ciency of the compression joints method was 98 % (100 % exclusion criteria were coagulopathic obstetric bleeding), in 1 case the application of compression joints was ineff ective, which required uterus extirpation. In 14 women out of 48 (29.1 %), menstrual irregularities were revealed. In 28 (61.5 %) women, postnatal depression was confi rmed. In 30 out of 36 (87 %) women were found to decrease in quality of life. In 8 (16.7 %) women, a recurrent spontaneous pregnancy occurred within 2 years aft er suturing.Conclusion. Compression sutures remain an effective method for stopping postpartum uterine bleeding, allowing women to maintain fertility. However, some factors, including high blood loss, can signifi cantly reduce the quality of women’s lives.
The role of high performance liquid chromatography in the functional state of the adrenal glands before and after surgical treatment for corticosteroma
Authors: Buinova M. O. , Vorokhobina N. V. , Velikanova L. I. , Strelnikova E. G. , Baranov V. L. 
Published: June 2020

Objective: It is to evaluate the functional state of the adrenal cortex after surgical treatment in patients with corticosteromas for optimize of tactic of postoperative management.Materials and methods: We examined 143 patients (43 men and 100 women) aged 51.3 ± 10.1 years with incidentaloma of adrenal glands and 27 healthy peopels (control group) aged 45.5 ± 5.7 years. Cushing's syndrome was detected in 22 patients, autonomous cortisol secretion was detected in 43. All patients had an analysis of the complaints, objective, laboratory and instrumental data in the preoperative and early postoperative periods. Assessment of levels glucocorticoid and mineralocorticoid hormones in biological fluids was carried out by immunoassay and high performance liquid chromatography.Results: The signs of adrenal cortex insufficiency in the early postoperative period were obtained in 77.3% of patients with Cushing's syndrome and in 25% of patients with autonomous cortisol secretion according to immunoassay and high performance liquid chromatography. An increase of level of corticosterone in the serum of blood in the preoperative period indicate the possibility development of adrenal insufficiency in the early postoperative period in all patients. Аn increase of levels of 11-deoxycortisol and 18-OH-corticosteronein in the serum of blood аnd urinary excretion of free cortisone, 18-OH-corticosterone and 6β-hydroxycortisol indicate the possibility development of adrenal insufficiency in the early postoperative period in patients with Cushing's syndrome.Conclusions: The determination of cortisol and aldosterone precursors by high performance liquid chromatography increases the accuracy of the diagnosis of glucocorticoid and mineralocorticoid function of the adrenal cortex in patients with Cushing's syndrome and with autonomous cortisol secretion in the early postoperative period.
Artificial Intelligence Education and Tools for Medical and Health Informatics Students: Systematic Review
Authors: Sapci A Hasan , Sapci H Aylin 
Published: June 2020

Background
The use of artificial intelligence (AI) in medicine will generate numerous application possibilities to improve patient care, provide real-time data analytics, and enable continuous patient monitoring. Clinicians and health informaticians should become familiar with machine learning and deep learning. Additionally, they should have a strong background in data analytics and data visualization to use, evaluate, and develop AI applications in clinical practice.

Objective
The main objective of this study was to evaluate the current state of AI training and the use of AI tools to enhance the learning experience.

Methods
A comprehensive systematic review was conducted to analyze the use of AI in medical and health informatics education, and to evaluate existing AI training practices. PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols) guidelines were followed. The studies that focused on the use of AI tools to enhance medical education and the studies that investigated teaching AI as a new competency were categorized separately to evaluate recent developments.

Results
This systematic review revealed that recent publications recommend the integration of AI training into medical and health informatics curricula.

Conclusions
To the best of our knowledge, this is the first systematic review exploring the current state of AI education in both medicine and health informatics. Since AI curricula have not been standardized and competencies have not been determined, a framework for specialized AI training in medical and health informatics education is proposed.
Tisagenlecleucel versus historical standard therapies for pediatric relapsed/refractory acute lymphoblastic leukemia
Authors: Ma Qiufei , Zhang Jie , O'Brien Elliott , Martin Amber L , Agostinho Andrea Chassot 
Published: June 2020

Aim:
We compared outcomes from a single-arm study of tisagenlecleucel with standard of care (SOC) regimens in pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia (ALL).
Methods:
The analysis included one tisagenlecleucel study, one blinatumomab study, one clofarabine monotherapy study, three studies of clofarabine combination regimens and two studies of other salvage chemotherapy. Matching-adjusted indirect comparison analyses were conducted.
Results:
After adjusting for baseline characteristics, tisagenlecleucel was associated with significantly prolonged overall survival compared with blinatumomab (hazard ratio [95% CI], 0.32 [0.16–0.64]); clofarabine monotherapy (0.24 [0.13–0.42]); clofarabine combination regimens (0.26 [0.15–0.45]); two salvage therapies (0.15 [0.09–0.25] and 0.27 [0.15–0.49]).
Conclusion:
The analysis demonstrated tisagenlecleucel was associated with substantially greater survival benefit versus all SOC regimens.
Hubungan Pengetahuan dan Sikap Terhadap Tindakan Pencegahan Gangguan Fungsional Pernapasan pada UMKM Pengrajin Mebel
Authors: Novianus Cornelis , Inaku Awaluddin Hidayat Ramli , Muzakir Haris 
Published: June 2020

ABSTRAK
Industri mebel khususnya pada tahapan produksi mebel mempunyai risiko terhadap kesehatan pekerja yang cukup besar berupa partikulat debu kayu dapat menyebabkan gangguan fungsional saluran pernapasan bagian atas dan bawah. Tujuan penelitian ini adalah mengetahui hubungan pengetahuan dan sikap dengan tindakan pencegahan gangguan fungsional pernapasan pada pekerja UMKM Mebel di Jakarta Timur. Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional, alat pengumpulan data penelitian menggunakan lembar kuesioner. Pengambilan sampel dengan teknik proposional random sampling berdasarkan wilayah Kecamatan yang ada di Jakarta Timur dengan jumlah sampel yang didapat 107 pekerja pada UMKM mebel. Analisis data dilakukan secara univariat dan bivariat dengan uji chi square. Berdasarkan hasil penelitian didapatkan variabel yang berhubungan dengan tindakan pencegahan gangguan fungsional pernapasan yaitu pengetahuan dengan p value 0,014, sikap dengan p value 0,019, pendidikan dengan p value 0,030. Sedangkan variabel yang tidak berhubungan dengan tindakan pencegahan gangguan fungsional pernapasan yaitu umur dengan p value 0,220 dan masa kerja dengan p value 0,999. Kesimpulan penelitian ini sebagian besar pekerja UMKM mebel dari segi pengetahuan, sikap, pendidikan dan tindakannya dalam pencegahan gangguan fungsional pernapasan sudah cukup baik. Rekomendasi untuk para pekerja mebel hendaknya dapat meningkatkan tindakan pencegahan gangguan fungsional pernapasan melalui memakai masker partikel secara disiplin, memasang yang sesuai panduan dan menggunakan masker partikel yang kondisinya layak pakai.
Kata Kunci: pengetahuan, sikap, pekerja mebel, tindakan pencegahan gangguan pernapasan.