bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the Prospective Associations Between Mindfulness Facets and Substance Use in Emerging Adulthood
Authors: Single Alanna , Keough Matthew T 
Published: September 2020

Abstract

Aims
Emerging adulthood (i.e. ages 18–25) is a developmental phase associated with frequent alcohol and cannabis use, placing this population at risk for substance use problems. Depression and anxiety (i.e. emotional psychopathology) are also prevalent during this phase, and some emerging adults use substances to cope with these negative emotions. Mindfulness—a multifaceted construct—involves being present in a nonjudgmental and nonreactive way. Certain mindfulness facets are particularly relevant in buffering against substance use. A recent longitudinal study [Single A, Bilevicius E, Johnson EA. et al. (2019) Specific facets of trait mindfulness reduce risk for alcohol and drug use among first-year undergraduate students. Mindfulness 10:1269–1279] showed that specific mindfulness facets (i.e. acting with awareness, nonjudging of inner experience and nonreactivity to inner experience) predicted decreased alcohol and drug use in undergraduates. These pathways were explained by low levels of emotional psychopathology.

Methods
This study expanded this recent work by using a three time-point longitudinal design and by including measures of both alcohol and cannabis use and related problems. Using MTurk, participants (N = 299) completed online measures of trait mindfulness, depression, anxiety, alcohol and cannabis use and related problems at three time-points, each 2 weeks apart. Structural equation modeling was used to test the hypotheses.

Results
The acting with awareness and nonjudging of inner experience facets predicted fewer alcohol problems, but not alcohol use, and this effect was mediated by low levels of emotional psychopathology. These results were not supported for cannabis use and problems.

Conclusion
This study demonstrates that there may be differences in the pathways from trait mindfulness to alcohol and cannabis use during emerging adulthood.
Branding the Geospatial Industry
Authors: Imaoka Laura Beltz 
Published: September 2020

AbstractThis study situates geospatial technology within the platform economy and constructs its brand culture, making it visible as a for-profit business rather than a utility. A critical lens is turned on the macroscopic economic and micro-social processes of the geospatial industry that result in the hegemonic relations and discursive regimes that legitimize and naturalize a common geospatially equipped, data-driven world. The annual user conventions and platform marketing of Esri, the global market leader in geographical information systems (GIS), acts as a site to observe how an imagined geospatial community of practitioners and investors is constructed. Branded content is unpacked to understand how the company’s image-making cultivates power relations between the public at large while negating itself as gatekeeper. These symbolic processes and collective practices help influence the uncritical investment and growth of the geospatial industry.
The American Board of Internal Medicine’s New Longitudinal Assessment Option and What It Means for Infectious Disease Specialists
Authors: Abraham George M , Saravolatz Louis D 
Published: September 2020

Abstract
As members of the American Board of Internal Medicine’s (ABIM) Infectious Disease (ID) Board we’ve heard from many of our colleagues asking for greater flexibility in maintaining their ABIM Board Certification. The ID Board—and ABIM as a whole—has engaged with the physician community over the past several years to gain a deeper understanding of what is most important to them, and how an enhanced Maintenance of Certification (MOC) program could support their commitment to keeping up with advances in medical knowledge. This article serves as an update about how ABIM has evolved its assessments over time and on our progress in developing a new longitudinal pathway that is anticipated to become available in most specialties in 2022, and will launch in ID in 2023.
Model averaging estimation for high-dimensional covariance matrices with a network structure
Authors: Zhu Rong , Zhang Xinyu , Ma Yanyuan , Zou Guohua 
Published: September 2020

Summary
In this paper, we develop a model averaging method to estimate a high-dimensional covariance matrix, where the candidate models are constructed by different orders of polynomial functions. We propose a Mallows-type model averaging criterion and select the weights by minimizing this criterion, which is an unbiased estimator of the expected in-sample squared error plus a constant. Then, we prove the asymptotic optimality of the resulting model average covariance estimators. Finally, we conduct numerical simulations and a case study on Chinese airport network structure data to demonstrate the usefulness of the proposed approaches.
Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry
Authors: Ge Yin , Steel Kevin , Antiochos Panagiotis , Bingham Scott , Abdullah Shuaib , Mikolich J Ronald , Arai Andrew E , Bandettini W Patricia , Shanbhag Sujata M , Patel Amit R , Farzaneh-Far Afshin , Heitner John F , Shenoy Chetan , Leung Steve W , Gonzalez Jorge A , Shah Dipan J , Raman Subha V , Nawaz Haseeb , Ferrari Victor A , Schulz-Menger Jeanette , Stuber Matthias , Simonetti Orlando P , Kwong Raymond Y 
Published: September 2020

AbstractAimsNon-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magnetic resonance imaging (CMR) in a multicentre registry.Methods and resultsThe SPINS Registry enrolled consecutive intermediate-risk patients who presented with a clinical indication for stress CMR in the USA between 2008 and 2013. Baseline demographic data including BMI, CMR indices, and ratings of study quality were collected. Primary outcome was defined by a composite of cardiovascular death and non-fatal myocardial infarction. Of the 2345 patients with available BMI included in the SPINS cohort, 1177 (50%) met criteria for obesity (BMI ≥ 30) with 531 (23%) at or above Class 2 obesity (BMI ≥ 35). In all BMI categories, &gt;95% of studies were of diagnostic quality for cine, perfusion, and late gadolinium enhancement (LGE) sequences. At a median follow-up of 5.4 years, those without ischaemia and LGE experienced a low annual rate of hard events (&lt;1%), across all BMI strata. In patients with obesity, both ischaemia [hazard ratio (HR): 2.14; 95% confidence interval (CI): 1.30–3.50; P = 0.003] and LGE (HR: 3.09; 95% CI: 1.83–5.22; P &lt; 0.001) maintained strong adjusted association with the primary outcome in a multivariable Cox regression model. Downstream referral rates to coronary angiography, revascularization, and cost of care spent on ischaemia testing did not significantly differ within the BMI categories.ConclusionIn this large multicentre registry, elevated BMI did not negatively impact the diagnostic quality and the effectiveness of risk stratification of patients referred for stress CMR.
Meta-Analysis of Present-Bias Estimation using Convex Time Budgets
Authors: Imai Taisuke , Rutter Tom A , Camerer Colin F 
Published: September 2020

AbstractWe examine 220 estimates of the present-bias parameter from 28 articles using the Convex Time Budget protocol. The literature shows that people are on average present-biased, but estimates exhibit substantial heterogeneity across studies. There is evidence of modest selective reporting in the direction of over-reporting present bias. The primary source of heterogeneity is the type of reward, either monetary or non-monetary, but this effect is weakened after correcting for selective reporting. In studies using monetary rewards, the delay until the issue of the reward associated with the ‘current’ time period influences estimates of the present-bias parameter.
A converging subset of soil bacterial taxa is permissive to the IncP-1 plasmid pKJK5 across a range of soil copper contamination
Authors: Song Jianxiao , Klümper Uli , Riber Leise , Dechesne Arnaud , Smets Barth F , Sørensen Søren J , Brandt Kristian K 
Published: September 2020

ABSTRACTStressors like metals or antibiotics can affect bacterial community permissiveness for plasmid uptake, but there is little knowledge about long-term effects of such stressors on the evolution of community permissiveness. We assessed the effect of more than 90 years of soil Cu contamination on bacterial community permissiveness (i.e. uptake ability) toward a gfp-tagged IncP-1 plasmid (pKJK5) introduced via an Escherichia coli donor. Plasmid transfer events from the donor to the recipient soil bacterial community were quantified and transconjugants were subsequently isolated by fluorescence activated cell sorting and identified by 16S rRNA gene amplicon sequencing. Transfer frequency of plasmid pKJK5 was reduced in bacterial communities extracted from highly Cu contaminated (4526 mg kg−1) soil compared to corresponding communities extracted from moderately (458 mg kg−1) Cu contaminated soil and a low Cu reference soil (15 mg kg−1). The taxonomic composition of the transconjugal pools showed remarkable similarities irrespective of the degree of soil Cu contamination and despite contrasting compositions of the extracted recipient communities and the original soil communities. Permissiveness assessed at the level of individual operational taxonomic units (OTUs; 16S rRNA gene 97% sequence similarity threshold) was only slightly affected by soil Cu level and high replicate variability of OTU-level permissiveness indicated a role of stochastic events in IncP-1 plasmid transfer or strain-to-strain permissiveness variability.
Assessment of phage-mediated inhibition of Salmonella Typhimurium treated with sublethal concentrations of ceftriaxone and ciprofloxacin
Authors: Jeon Gibeom , Ahn Juhee 
Published: September 2020

ABSTRACT
This study was designed to evaluate the synergistic effect of phage (P22) and antibiotic on the inhibition of Salmonella Typhimurium exposed to ceftriaxone (CEF) and ciprofloxacin (CIP). The effect of phage and antibiotic treatments was evaluated by plaque size, disk diffusion, antibiotic susceptibility and phage multiplication assays. The sequential treatment effect of phage and antibiotic was carried out in different treatment order and time for 12 h at 37°C. P22 plaque sizes were increased by 28 and 71%, respectively, in the presence of CEF and CIP. The clear zone sizes in disk diffusion assay were significantly increased to &gt;37 mm in the presence of CEF and CIP compared to the control (28–31 mm). Pre-treatment with P22 enhanced the antimicrobial effect of CIP, showing &gt;2 log reduction after a 12 h incubation. Phage P22 combined with antibiotics (CEF and CIP) effectively inhibited the growth of S. Typhimurium depending on the treatment order and time. These results provide useful information for understanding the synergistic effect of phage and antibiotic treatment which can be an effective option to control antibiotic resistant pathogens.
Undetectable viral RNA in oocytes from SARS-CoV-2 positive women
Authors: Barragan M , Guillén J J , Martin-Palomino N , Rodriguez A , Vassena R 
Published: September 2020

Abstract
A central concern for the safe provision of ART during the current coronavirus disease 2019 (COVID-19) pandemic is the possibility of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through gametes and preimplantation embryos. Unfortunately, data on SARS-CoV-2 viral presence in oocytes of infected individuals are not available to date. We describe the case of two women who underwent controlled ovarian stimulation and tested positive to SARS-CoV-2 infection by PCR on the day of oocyte collection. The viral RNA for gene N was undetectable in all the oocytes analyzed from the two women.
Physiological responses to temperature and ocean acidification in tropical fleshy macroalgae with varying affinities for inorganic carbon
Authors: Ho Maureen , McBroom James , Bergstrom Ellie , Diaz-Pulido Guillermo 
Published: September 2020

Abstract
Marine macroalgae have variable carbon-uptake strategies that complicate predicting responses to environmental changes. In seawater, dissolved inorganic carbon availability can affect the underlying physiological mechanisms influencing carbon uptake. We tested the interactive effects of ocean acidification (OA) and warming on two HCO3−-users (Lobophora sp. and Amansia rhodantha), a predominately CO2-user (Avrainvillea nigricans), and a sole CO2-user (Plocamium hamatum) in the Great Barrier Reef, Australia. We examined metabolic rates, growth, and carbon isotope values (δ13C) in algae at 26, 28, or 30°C under ambient or elevated pCO2 (∼1000 µatm). Under OA, δ13C values for the HCO3−-users decreased, indicating less reliance on HCO3−, while δ13C values for CO2-users were unaffected. Both HCO3−-users decreased in growth across temperatures under ambient pCO2, but this negative effect was alleviated by OA at 30°C. A. nigricans lost biomass across all treatments and P. hamatum was most sensitive, with reduced survival in all physiological responses. Metabolic rates varied greatly to interacting temperature and OA and indicated a decoupling between the relationship of photosynthesis and growth. Furthermore, our findings suggest HCO3−-users are more responsive to future CO2 changes, and highlight examining carbon physiology to infer potential responses to interacting environmental stressors.
Sacred Time and Rabbinic Literature: New Directions for an Old Question
Authors: Kaye Lynn 
Published: September 2020

AbstractThis article questions the utility of the term “sacred time.” In other words, it cautions against allowing sacred time to obscure how scholars study the dynamic relations between temporalities and sanctity in classical rabbinic texts (c. 200–550 CE). The achievement of recent Biblical and Jewish studies scholars who rejected characterizations of Hebrew or Jewish time as monolithic was their decoupling of the patterning or shape of events from what it means for time to be holy or for there to be a time for holiness. In the wake of such corrective efforts, scholars can now examine how rabbinic texts engage the quality of holiness as it pertains to durations, human activities, embodied temporal awareness, the time of exegesis, or to God’s time. This article distinguishes God’s time and human moments of recurrence and connection from eternity and sacred time through analysis of late antique Palestinian midrashim and presents directions for future study of holiness and time in classical rabbinic literature.
Predictive article recommendation using natural language processing and machine learning to support evidence updates in domain-specific knowledge graphs
Authors: Sharma Bhuvan , Willis Van C , Huettner Claudia S , Beaty Kirk , Snowdon Jane L , Xue Shang , South Brett R , Jackson Gretchen P , Weeraratne Dilhan , Michelini Vanessa 
Published: September 2020

Abstract

Objectives
Describe an augmented intelligence approach to facilitate the update of evidence for associations in knowledge graphs.

Methods
New publications are filtered through multiple machine learning study classifiers, and filtered publications are combined with articles already included as evidence in the knowledge graph. The corpus is then subjected to named entity recognition, semantic dictionary mapping, term vector space modeling, pairwise similarity, and focal entity match to identify highly related publications. Subject matter experts review recommended articles to assess inclusion in the knowledge graph; discrepancies are resolved by consensus.

Results
Study classifiers achieved F-scores from 0.88 to 0.94, and similarity thresholds for each study type were determined by experimentation. Our approach reduces human literature review load by 99%, and over the past 12 months, 41% of recommendations were accepted to update the knowledge graph.

Conclusion
Integrated search and recommendation exploiting current evidence in a knowledge graph is useful for reducing human cognition load.
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC
Authors: Xu Mengyao , Huang Shan , Dong Xiaoli , Chen Yanan , Li Miao , Shi Wen , Wang Guanwen , Huang Chongbiao , Wang Qiong , Liu Yanhua , Sun Peiqing , Yang Shuang , Xiang Rong , Chang Antao 
Published: September 2020

Abstract
Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients. Forced expression of ATOH8-V1 dramatically enhances, while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines. Moreover, ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC, which in turn enhances the metastasis of breast cancer. Altogether, our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis, suggesting that ATOH8-V1 is a potential therapeutic target for treatment of metastatic cancers.
Detection of Dermacentor andersoni (Acari: Ixodidae) in Brazil on a Human Traveler Returning from the United States
Authors: Faccini-Martínez Álvaro A , Martins Thiago F , Silveira Iara , Labruna Marcelo B 
Published: September 2020

Abstract
Only one previous record of an exotic tick on a Brazilian traveler has been reported. Here, we report the detection of Dermacentor andersoni (Stiles) in Brazil while attached to a human traveler returning from the United States. This report is the fifth record of D. andersoni as an exotic tick, and the second record of an exotic tick on a South American traveler.
Management of a life-threatening intercostal artery bleeding, difficult to visualize in open surgery: a case report
Authors: Laugsand Eivor Alette , Xanthoulis Athanasios 
Published: September 2020

Abstract
Life-threatening bleeding from an intercostal artery is a rare and challenging event. A 74-year-old patient with a right-sided pleural effusion was treated by a pigtail pleural drain. He developed a large haemothorax, initially addressed by a large bore chest tube. As he became haemodynamically unstable, he required an emergency anterolateral right thoracotomy. It was difficult to visualize and reach the bleeding vessel during open surgery. A 30° laparoscopy camera was introduced and the bleeding site was identified. An incision was made directly over the bleeding site and the two ends of the lacerated intercostal artery were ligated by two externally placed figure-of-eight sutures. The patient survived and recovered fully. As most general surgeons, even at smaller hospitals, are familiar with laparoscopy, the technique described here may be useful for other surgeons to employ if a life-threatening intercostal artery injury occurs.
Conventional therapy and new antifungal drugs againstMalasseziainfections
Authors: Rhimi Wafa , Theelen Bart , Boekhout Teun , Aneke Chioma Inyang , Otranto Domenico , Cafarchia Claudia 
Published: September 2020

ABSTRACTMalassezia yeasts are commensal microorganisms occurring on the skin of humans and animals causing dermatological disorders or systemic infections in severely immunocompromised hosts. Despite attempts to control such yeast infections with topical and systemic antifungals, recurrence of clinical signs of skin infections as well as treatment failure in preventing or treating Malassezia furfur fungemia have been reported most likely due to wrong management of these infections (e.g., due to early termination of treatment) or due to the occurrence of resistant phenomena. Standardized methods for in vitro antifungal susceptibility tests of these yeasts are still lacking, thus resulting in variable susceptibility profiles to azoles among Malassezia spp. and a lack of clinical breakpoints. The inherent limitations to the current pharmacological treatments for Malassezia infections both in humans and animals, stimulated the interest of the scientific community to discover new, effective antifungal drugs or substances to treat these infections. In this review, data about the in vivo and in vitro antifungal activity of the most commonly employed drugs (i.e., azoles, polyenes, allylamines, and echinocandins) against Malassezia yeasts, with a focus on human bloodstream infections, are summarized and their clinical implications are discussed. In addition, the usefulness of alternative compounds is discussed.
OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines
Authors: Gurumayum Sanathoi , Jiang Puzi , Hao Xiaowen , Campos Tulio L , Young Neil D , Korhonen Pasi K , Gasser Robin B , Bork Peer , Zhao Xing-Ming , He Li-jie , Chen Wei-Hua 
Published: September 2020

Abstract
OGEE is an Online GEne Essentiality database. Gene essentiality is not a static and binary property, rather a context-dependent and evolvable property in all forms of life. In OGEE we collect not only experimentally tested essential and non-essential genes, but also associated gene properties that contributes to gene essentiality. We tagged conditionally essential genes that show variable essentiality statuses across datasets to highlight complex interplays between gene functions and environmental/experimental perturbations. OGEE v3 contains gene essentiality datasets for 91 species; almost doubled from 48 species in previous version. To accommodate recent advances on human cancer essential genes (as known as tumor dependency genes) that could serve as targets for cancer treatment and/or drug development, we expanded the collection of human essential genes from 16 cell lines in previous to 581. These human cancer cell lines were tested with high-throughput experiments such as CRISPR-Cas9 and RNAi; in total, 150 of which were tested by both techniques. We also included factors known to contribute to gene essentiality for these cell lines, such as genomic mutation, methylation and gene expression, along with extensive graphical visualizations for ease of understanding of these factors. OGEE v3 can be accessible freely at https://v3.ogee.info.
RADON MEASUREMENTS IN BIG BUILDINGS: PILOT STUDY IN RUSSIA
Authors: Vasilyev A , Yarmoshenko I , Onishchenko A , Hoffmann M , Malinovsky G , Marenny A , Karl L 
Published: September 2020

Abstract
Detailed analysis of indoor radon concentration distribution by floors was conducted in four children institutions, one office building and two residential houses in Russian cities to develop approaches to draw up a program of radon survey for big buildings. Higher variability of radon concentration was found in high geogenic radon potential (GRP) area when the soil is the main source of radon. No essential dependence of radon concentration on the floor in high-rise buildings was found in low GRP area. The number of required radon measurements is estimated using obtained characteristics of radon variability.