bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAA-Based Treatment for HIV–HCV-Coinfected Patients: Analysis of Factors of Sustained Virological Response in a Real-Life Study
Authors: Alessio Loredana , Onorato Lorenzo , Sangiovanni Vincenzo , Borrelli Francesco , Manzillo Elio , Esposito Vincenzo , Simeone Filomena , Martini Salvatore , Capoluongo Nicolina , Leone Sebastiano , Filippo Giovanni Di , D'Abbraccio Maurizio , Aprea Lucia , Megna Angelo Salomone , Milano Eugenio , Rizzo Viviana , Saracino Annalisa , Coppola Nicola 
Published: April 2020

Background The aim of the present study was to evaluate in HIV-infected patients treated with a direct-acting antiviral agent (DAA)-based regimen the variables associated with sustained virological response (SVR) and the trend in biochemical parameters and clinical events during and after DAA regimen. Methods We performed a multicentre retrospective cohort study, enrolling all 243 HIV–HCV-coinfected adult patients treated with DAAs between January 2015 and December 2018 in one of the nine participating Infectious Disease Centers in southern Italy, eight in Campania and one in Apulia. Results Of the 243 patients enrolled, 233 (95.9%) obtained an SVR at 12 weeks (SVR12). Of the 10 patients with non-SVR, 7 were tested for NS3, NS5A and NS5B resistance-associated substitutions (RASs) by sequencing analysis and 6 showed at least 1 major RAS in 1 HCV region (all in NS5A, 2 in NS5B and 1 in NS3). Comparing the 233 patients achieving SVR and the 10 non-achievers, no variable was independently associated with non-SVR. During and after DAA regimen, no modification in the biochemical parameters and clinical events was observed; however, the serum cholesterol and low-density lipoprotein (LDL) levels showed an increase (from 159 ±41.3 mg/dl at baseline to 174 ±44.5 mg/dl at week 12 after stopping treatment, P<0.001, and from 92 ±34.6 mg/dl to 109.4 ±73.7 mg/dl, P=0.002, respectively). Conclusions The treatment with DAAs led to a high SVR12 rate in HIV–HCV-coinfected subjects, irrespective of epidemiological, clinical or virological characteristics. However, the DAA regimen was associated with an increase in total- and LDL-cholesterol, to be taken into account in the management of HIV infection
1150 Kyphoplasties Over 7 Years: Indications, Techniques, and Intraoperative Complications
Authors: McArthur Nicholas , Kasperk Christian , Baier Martin , Tanner Michael , Gritzbach Bernd , Schoierer Oliver , Rothfischer Wolfram , Krohmer Gerhard , Hillmeier Jochen , Kock Hans-Jürgen , Meeder Peter Jürgen , Huber Franz-Xaver 
Published: April 2020

In our cohort of 555 patients with a total of 1150 vertebral fractures treated with kyphoplasty we performed a 30-day postoperative analysis of cement leakage, neurological symptoms, pulmonary embolism, and infections. In our department, 22% of kyphoplasties were performed with calcium phosphate cement and the remainder with polymethylmethacrylate. All patients were initially assessed by an interdisciplinary kyphoplasty colloquium, composed of consultants in traumatology, radiology, and endocrinology. Indications included fresh traumatic vertebral fractures; painful sintered osteoporotic vertebrae; osteolysis and painful vertebral body collapse caused by multiple myelomas; and lymphomas and pathological fractures due to metastases of malignant tumors (prostate cancer, breast cancer, ovarian cancer, and malignant melanoma) or benign vertebral tumors (hemangioma).
Contraindications included patients with instability of the posterior wall and/or pedicles, an infection of the fractured vertebra, a severe hemorrhagic diathesis, known allergies to the cements, pregnancy, and ASA score of 4. The standard postoperative computed tomography scan of the kyphoplasty-treated vertebrae revealed a dorsal cement leakage in 38 vertebrae representing 3.3% of all levels. A permanent monoparesis of the left leg, 2 cases of temporary neurological deficits, 2 cases of hemorrhage, and 1 asymptomatic pulmonary embolism were observed as postoperative complications. We observed no complications relating to polymethylmethacrylate described in the literature. By careful interdisciplinary indication setting and a standardized treatment model, kyphoplasty presents a safe and effective procedure for the treatment of various vertebral fractures.
Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes
Authors: Kobayashi Michihiro , Lin Yang , Mishra Akansha , Shelly Chris , Gao Rui , Reeh Colton W. , Wang Paul Zhiping , Xi Rongwen , Liu Yunlong , Wenzel Pamela , Ghosn Eliver , Liu Yan , Yoshimoto Momoko 
Published: April 2020

Abstract
The self-renewal ability is a unique property of fetal-derived innate-like B-1a lymphocytes, which survive and function without being replenished by bone marrow (BM) progenitors. However, the mechanism by which IgM-secreting mature B-1a lymphocytes self-renew is poorly understood. In this study, we showed that Bmi1 was critically involved in this process. Although Bmi1 is considered essential for lymphopoiesis, the number of mature conventional B cells was not altered when Bmi1 was deleted in the B cell lineage. In contrast, the number of peritoneal B-1a cells was significantly reduced. Peritoneal cell transfer assays revealed diminished self-renewal ability of Bmi1-deleted B-1a cells, which was restored by additional deletion of Ink4-Arf, the well-known target of Bmi1. Fetal liver cells with B cell–specific Bmi1 deletion failed to repopulate peritoneal B-1a cells, but not other B-2 lymphocytes after transplantation assays, suggesting that Bmi1 may be involved in the developmental process of B-1 progenitors to mature B-1a cells. Although Bmi1 deletion has also been shown to alter the microenvironment for hematopoietic stem cells, fat-associated lymphoid clusters, the reported niche for B-1a cells, were not impaired in Bmi1−/− mice. RNA expression profiling suggested lysine demethylase 5B (Kdm5b) as another possible target of Bmi1, which was elevated in Bmi1−/− B-1a cells in a stress setting and might repress B-1a cell proliferation. Our work has indicated that Bmi1 plays pivotal roles in self-renewal and maintenance of fetal-derived B-1a cells.
Near-global-scale high-resolution seasonal simulations with WRF-Noah-MP v.3.8.1
Authors: Schwitalla Thomas , Warrach-Sagi Kirsten , Wulfmeyer Volker , Resch Michael 
Published: April 2020

Abstract. The added value of global simulations on the
convection-permitting (CP) scale is a subject of extensive research in the
earth system science community. An increase in predictive skill can be
expected due to advanced representations of feedbacks and teleconnections in
the ocean–land–atmosphere system. However, the proof of this hypothesis by
corresponding simulations is computationally and scientifically extremely
demanding. We present a novel latitude-belt simulation from 57∘ S
to 65∘ N using the Weather Research and Forecasting (WRF)-Noah-MP model system with a grid increment
of 0.03∘ over a period of 5 months forced by sea surface
temperature observations. In comparison to a latitude-belt simulation with
45 km resolution, at CP resolution the representation of the
spatial-temporal scales and the organization of tropical convection
are improved considerably. The teleconnection pattern is very close to that
of the operational European Centre for Medium Range Weather
Forecasting (ECMWF) analyses. The CP simulation is associated with an
improvement of the precipitation forecast over South America, Africa, and
the Indian Ocean and considerably improves the representation of cloud
coverage along the tropics. Our results demonstrate a significant added
value of future simulations on the CP scale up to the seasonal forecast
range.
Efectos de un Programa de Intervención sobre las habilidades emocionales en niños preescolares
Authors: Grimaldo Muchotrigo Mirian , Merino-Soto César 
Published: April 2020

RESUMENEl objetivo de este estudio es determinar los efectos del programa de intervención Descubriendo Mis emociones cuyo objetivo es reconocer y expresar las emociones positivas y morales, y el manejo de emociones negativas en un grupo de niños/as en edad preescolar de Lima. El estudio ha seguido un diseño de investigación cuasi experimental con grupo de control con pre test y post test. La muestra estuvo conformada por 125 participantes con una edad promedio de 5 años (95 del grupo experimental y 30 del control). Se determinó la evidencia basada en la validez de contenido, de constructo y confiabilidad del instrumento. El programa se organizó en diez sesiones semanales de aproximadamente dos horas cada una, mediante la aplicación de técnicas participativas. Al inicio de la intervención, no se encontraron diferencias significativas en los puntajes obtenidos por los niños/as que conformaron el grupo control y el grupo experimental. En el análisis intragrupos, los dos grupos experimentales mostraron leves diferencias; en el análisis entre-grupos, se detectaron claras diferencias entre el grupo control y los grupos experimentales; en el análisis clinicométrico, hubo un mayor cambio confiable y clínico en los grupos experimentales. Se discuten las implicaciones de un programa orientado al reconocimiento de emociones en niños/as. ABSTRACT The goal of this study is to determine the effects of an intervention program discovering my Emotions for recognizing and expressing positive, negative and moral emotions. It was conducted with a group of preschooler’s children in Lima. The study followed a quasi-experimental research design with pre-test and post-test control groups. The study sample comprised 125 participants with an average age of 5 years (95 in the experimental group and 30 in the control group), through intentional sample. Content validity, construct validity and reliability of the instrument were determined. The program was organized in ten weekly sessions of approximately two hours per session by applying participatory techniques. In the pretest, no significant differences were found in the scores obtained from the control group and the experimental group. In the intra-test group analysis, the two experimental groups showed slight differences. In the posttest, clear differences were detected between the control group and the experimental groups; in the clinical metric analysis, there was a greater reliable and clinical change in the experimental groups. The strategies, activities and participatory techniques are analysed, the regular attendance of the participants, among other aspects and the implications of the program oriented to the recognition of emotions in children are discussed. Pre-school children who participated in the program were able to recognize and express positive, moral and negative emotions. This demonstrates the effectiveness of the program and verifies the hypothesis formulated.
El pensamiento computacional en Educación. Análisis bibliométrico y temático.
Authors: Roig-Vila Rosabel , Moreno-Isac Víctor 
Published: April 2020

El pensamiento computacional se está considerando actualmente como una de las competencias más demandadas y, de ahí, su planteamiento en el contexto educativo. Este trabajo trata de analizar la literatura científica sobre la aplicación del pensamiento computacional en el ámbito educativo publicada en las colecciones principales de la base de datos Web of Science. Se han tenido en cuenta las variables de año de publicación, los países con más producciones, los autores más productivos en este campo y fuentes documentales con mayor número de publicaciones. Asimismo, se ha realizado una clasificación según los tipos de documentos y los métodos de investigación utilizados, así como las etapas educativas objeto de estudio y los lenguajes de programación utilizados. Se ha hallado una tendencia creciente de publicaciones en esta temática, donde España es uno de los países donde más se publica. Además, se ha observado cómo este campo de estudio se ha abordado desde los dos principales métodos de investigación –cuantitativo y cualitativo— y la etapa educativa más investigada es la educación primaria. Por último, se lleva a cabo una discusión de los resultados y conclusiones, sirviendo este documento como punto de partida para futuras investigaciones sobre el pensamiento computacional en educación.
The status of computational thinking as one of the most demanded skills explains why suggestions are currently being made to apply it within the educational context. This paper constitutes an attempt to analyze the scientific literature on the implementation of computational thinking in the field of education published in the most important Web of Science database collections. Attention was paid to four variables, namely: publication year; countries with more productions; the most productive authors in this field; and documentary sources with a higher number of publications. Added to this, we carried out a classification according to the types of documents and the research methods used, along with the educational stages under study and the programming language adopted. Publications are undoubtedly on an upward trend, Spain standing out as one of the most productive countries in this area. Likewise, evidence demonstrates not only that this field of study has been addressed using the two main research methods —quantitative and qualitative— but also that the emphasis has traditionally been placed on the primary education stage. A discussion of the results obtained as well as the conclusions drawn will put an end to this paper, which can hopefully serve as a starting point for future research works on the utilization of computational thinking in education.
Integración de Pensamiento Computacional en Educación Básica. Dos Experiencias Pedagógicas de Aprendizaje Colaborativo online
Authors: Basogain Olabe Xabier , Olmedo Parco María Elena 
Published: April 2020

Los países del mundo han incluido en sus agendas educativas la incorporación del Pensamiento Computacional (PC) en la Educación Básica. A pesar de los esfuerzos de las autoridades escolares, los sistemas escolares tienen dificultades en desarrollar esta propuesta en las aulas tradicionales. En este artículo presentamos dos experiencias basadas en el uso de tecnologías y metodologías educativas que han ayudado a superar estas dificultades, logrando llevar el PC al aula de forma eficaz para los estudiantes, profesorado y centros escolares. Las experiencias se han desarrollado en colaboración con instituciones educativas y ministerios de educación de dos países de Latinoamérica. Las tecnologías educativas utilizadas son los entornos virtuales de aprendizaje (EVA), los sistemas de colaboración síncronos, y los entornos de programación online Scratch/Snap. Las metodologías educativas desarrolladas se basan en el trabajo colaborativo profesorado-tutores, profesorado-estudiantes, y estudiantes-estudiantes. Ambas, tecnologías y metodologías educativas, se han utilizado de forma conjunta para desarrollar a través del PC la capacidad de nuestros estudiantes para resolver problemas relacionados con la vida diaria y con el mundo laboral.
Countries in the world have included in their educational agendas the incorporation of Computational Thinking (CT) in Compulsory Education. Despite the efforts of the school authorities, the school systems have difficulties in developing this proposal in the traditional classrooms. In this article we present two experiences based on the use of educational technologies and methodologies that have helped overcome these difficulties by bringing the PC to the Classroom effectively for students, teachers and schools. Experiences have been developed in collaboration with educational institutions and ministries of education in two Latin American countries. The educational technologies used are virtual learning environments (VLE), synchronous collaboration systems, and Scratch / Snap online programming environments. The educational methodologies developed are based on collaborative work teachers-tutors, teachers-students, and students-students. Both educational technologies and methodologies have been used together to develop, through the PC, the ability of our students to solve problems related to daily life and the working world.
Effect of Clinical X-rays on Methicillin-resistant Staphylococcus aureus and Other Bacterial Isolates from Radiology Equipment
Authors: Adebiyi K. S. , Ehigiamusoe F. O. , Oshoma C. E. 
Published: April 2020

Aim: Methicillin-resistant Staphylococcus aureus (MRSA) and other nosocomial pathogens are frequently isolated from the Radiology Department of hospitals. These pathogens are repeatedly exposed to refracted electromagnetic radiations during diagnostic clinical X-ray imaging sessions. This study thus investigated the effect of these refracted radiations on the nosocomial bacteria found within Radiology units and their possible survival mechanism.
Methodology: Swab samples were collected from three (3) Radiology units; plain radiography machine, ultrasound machine and mammography machine. The samples were cultured and identified following standard microbiology procedures. The identified bacterial isolates were exposed to X-rays at different KVp and MAs factors, cell counts and catalase activities of the isolates were determined using standard procedures.
Results: The bacterial isolates identified were Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and Enterococcus faecalis where Staphylococcus aureus had the highest prevalence (29.41%) and Enterococcus faecalis (11.76%) was least. The highest survival level to KVp and MAs exposure was S. aureus with values 11.16 ± 0.86 x103 and 19.50 ± 0.16 x103 cfu/ml respectively while Enterococcus faecalis was least with negative value. There was a positive correlation between catalase activity and cell survival with R-value of 0.2512 and 0.6925 for KVp and MAs exposure factors respectively.
Conclusion: The study revealed that clinical X-ray does not completely eliminate nosocomial pathogens within Radiology Department and MRSA is a formidable bacterium in the units.
Effects of Lignocaine-Diazepam Combination in Lumbo-Sacral Epidural Anaesthetized Dogs Undergoing Caudectomy
Authors: Yakubu A. S. , Usman I. B. , Kabir H. , Abubakar A. A. , Bello A. , Oviawe E. I. , Abubakar N. , Bodinga H. A. 
Published: April 2020

General anaesthesia is known to be associated with the risk of cardiopulmonary depression, therefore the use of a safer means of anaesthesia as an alternative has to be explored. Epidural anaesthesia technique is known for its simplicity, safety and effectiveness and is one of the most frequently used regional anesthetic techniques described for surgical procedures caudal to the umbilicus in small animal practice. The main aim of this study was to evaluate the effects of lumbo-sacral epidural injection of a mixture of 7.5 mg/kg of 2% lignocaine solution and 0.2 mg/kg 0.5% diazepam solution in 10 apparently healthy Nigerian local dogs undergoing caudectomy. Onset of neural blocked recorded was 6.5 ± 1.35 min (mean ± SD), duration of analgesia was 54.4 ± 5.38 min (mean ± SD) and duration of recumbency was 115.1 ± 36.1min (mean ± SD). Changes observed in the Pulse rate (PR), Mean arterial blood pressure (MAP), Respiratory rate (RR) and Rectal temperature (RT) were recorded at 10 min intervals throughout the duration of the procedure. There were no significant differences (p>0.05) in the mean physiological parameters observed as compared to the baseline values. Blood samples were also taken at 15 min interval throughout the duration of the procedure to determine the effects of the epidurally administered lignocaine-diazepam combination on haematological and serum biochemical indices. No significant differences (p>0.05) were observed in the mean haematological (PCV, RBC, WBC, Hb and CBC) and serum biochemical indices (ALT, ALP, Creatinine and BUN). It was concluded that epidurally administered lignocaine-diazepam mixture at 7.5 mg/kg and 0.2 mg/kg respectively had a fast onset of neural blockade, adequate and long duration of analgesia without profound effects on haemodynamic and cardiopulmonary system.
Children's response biases to results of object sharing
Authors: Okanda Mako , Taniguchi Kosuke 
Published: April 2020

SummaryThis study investigated whether 2‐ to 6‐year‐old children exhibit a response bias to questions pertaining to the results of sharing objects that should attract their interest. An experimenter distributed four objects between herself/himself and a child, equally or unequally (more to the child or more to the experimenter) and asked the child yes‐no questions: “Is this okay?” and “Is this bad?” The results indicated that 2‐ and 3‐year‐olds exhibited a yes bias in all conditions, 4‐year‐olds exhibited a yes bias to the equal condition and to the unequal condition with more distributed to the child, and 5‐year‐olds exhibited a yes bias to both unequal conditions, whereas 6‐year‐olds did not show any response bias. Young preschoolers exhibited a yes bias regardless of questions and children may become able to say both “yes” and “no” appropriately to questions about object sharing after the age of six.
Direct Access to (±)‐10‐Desbromoarborescidine A from Tryptamine and Pentane‐1,5‐diol
Authors: Sahoo Apurba Ranjan , Lalitha Gummidi , Murugesh V. , Bruneau Christian , Sharma Gangavaram V. M. , Suresh Surisetti , Achard Mathieu 
Published: April 2020

AbstractA single step synthetic strategy for (±)10‐ desbromoarborescidine A is described. Starting from tryptamine and pentane‐1,5‐diol, this acceptorless dehydrogenative condensation process is efficiently catalyzed by a ruthenium complex featuring proton‐responsive phosphine‐pyridone ligand.
Polymer Lamellae as Reaction Intermediates in the Formation of Copper Nanospheres as Evidenced by In Situ X‐ray Studies
Authors: Mantella Valeria , Strach Michal , Frank Kilian , Pankhurst James R. , Stoian Dragos , Gadiyar Chethana , Nickel Bert , Buonsanti Raffaella 
Published: April 2020

AbstractThe classical nucleation theory (CNT) is the most common theoretical framework used to explain particle formation. However, nucleation is a complex process with reaction pathways which are often not covered by the CNT. Herein, we study the formation mechanism of copper nanospheres using in situ X‐ray absorption and scattering measurements. We reveal that their nucleation involves coordination polymer lamellae as pre‐nucleation structures occupying a local minimum in the reaction energy landscape. Having learned this, we achieved a superior monodispersity for Cu nanospheres of different sizes. This report exemplifies the importance of developing a more realistic picture of the mechanism involved in the formation of inorganic nanoparticles to develop a rational approach to their synthesis.
High oil absorbable superhydrophobic melamine sponges and evaluation in oil spill clean‐ups
Authors: Shui Yonggang , Xian Yupei , Chen Lichao , Li Meimei , Yao Yongyi , Zhang Qiyi 
Published: April 2020

AbstractFacing the environmental crisis to leakage of oil spills and chemicals, multifunctional absorbent with high oil absorption and selectivity urgently need to solve this matter. In our work, a high oil sorbent was designed and favorably fabricated by two simple immersions using melamine sponge as pristine and a series of oils were used to evaluate the oil absorption performances of the absorbent. Two immersions include adhesion of dopamine and grafting of the long chain hydrophobic agent. The prepared material is superhydrophobic with water contact angle is 165.9° ± 2.17 and high oil absorption to chloroform is 174 times by own weight, other oils are close to or over 100 times, but to water is only 0.5 times. The reusability reveals that the average recovery can keep more than 95% after 20 cycles. These advantages make it really potential to use in oil spill clean.