bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upgrade Rate of Flat Epithelial Atypia Diagnosed at Stereotactic Core Needle Biopsy of Microcalcifications: Is Excisional Biopsy Indicated?
Authors: Gordon Paula B , Branch Emma 
Published: June 2020

Abstract

Objective
Whether the optimal management of pure flat epithelial atypia (FEA) found on core needle biopsy (CNB) specimens is surgical excision or imaging follow-up remains controversial. This study aimed to determine the upgrade rate to ductal carcinoma in situ (DCIS), invasive carcinoma or a high-risk lesion (atypical ductal hyperplasia, atypical lobular hyperplasia, or lobular carcinoma in situ), and it explored the relationship between a family history of breast cancer and the risk of upgrade.

Methods
Cases with pure FEA found on stereotactic CNB of microcalcifications between March 2011 to December 2017 were followed by excisional biopsy or periodic imaging. The proportion of cases upgraded to a high-risk lesion and the odds of upgrade as related to a family history of breast cancer were determined with 95% confidence intervals (CIs).

Results
We identified 622 cases of pure FEA; 101 (16.2%) underwent surgical excision and 269 (43.2%) had imaging follow-up of ≥ 24 months. There were no upgrades to DCIS or invasive cancer in any of these 370 individuals (0%), and 4.6% (17/370; 95% CI: 2.9%–7.2%) were upgraded to a high-risk lesion. There was a nonstatistically significant trend between family history and upgrade to high-risk lesion (odds ratio 1.72 [95% CI: 0.65%–4.57%]).

Conclusion
In our study, the upgrade rate of pure FEA to malignancy was 0%. We suggest that regular imaging follow-up is an appropriate alternative to surgery. Because of potential differences in biopsy techniques and pathologist interpretation of the primary biopsy, individual institutions should audit their own results prior to altering their management of FEA.
Impact of Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) Feeding on Tart Cherry (Rosales: Rosaceae) Quality and Yield in Utah
Authors: Schumm Zachary R , Alston Diane G , Spears Lori R , Manlove Kezia 
Published: June 2020

Abstract
Brown marmorated stink bug (Halyomorpha halys Stål) is an invasive and economically important agricultural and ornamental insect pest now established in 46 U.S. states. It was first detected in Utah in 2012 and began causing agricultural damage in 2017. Tart cherry (Prunus cerasus Linnaeus) is a major processed agricultural commodity in Utah; yet, its susceptibility to brown marmorated stink bug is unstudied. Limb cages with six brown marmorated stink bug adults, nymphs, or no brown marmorated stink bug were established in a randomized complete block design in a tart cherry orchard to determine feeding impact on different fruit developmental stages. After 1 wk of feeding, half of the fruits in each cage were removed to assess feeding intensity, and the remainder left through maturity to assess marketability and quality. Feeding by adults and nymphs between petal fall and fruit pit hardening, even at feeding pressures as low as 1.7–4.0 feeding sites per fruit, caused 100% abscission of fruits, significantly reducing marketability when compared with the control treatment. For fruits that escaped abscission and matured, few quality differences were detected among treatments, indicating that brown marmorated stink bug feeding caused minimal detectable quality loss to this processed tree fruit crop. We conclude that tart cherries are at risk of abscission with short-term brown marmorated stink bug feeding between petal fall and pit hardening when overwintered adults or F1 nymphs are present in orchards, and suggest that longer-term feeding may be necessary to cause quality and yield reductions after pit hardening.
Regulating patient access to therapeutics in Denmark: a rhetorical analysis of welfare imaginaries in public controversy
Authors: Møllebæk Mathias 
Published: June 2020

ABSTRACT
In this article, I argue that the social imaginaries that inform biomedical regulation circulate not only in technical spheres populated by experts but that they are equally articulated (and vehemently contested) in national public spheres in more popular forms of communication. I examine the relation between a national healthcare imaginary and the regulation of therapeutics through a public controversy about access to an innovative therapeutic indicated for spinal muscular atrophy. The establishment of the Danish Medicines Council, a new health technology assessment institution, and its decision to restrict access to an innovative therapeutic sparked controversy in 2017 involving political proponents, adversaries, and patients, among others. In a variety of ways, they rhetorically mobilized or contested the Danish universalist welfare imaginary which contains promises and prospects of solidarity, security, and absence of market forces in universal healthcare, including access to therapeutics. I use a combination of media content analysis and rhetorical close reading methods to analyze how the imaginary was drawn upon in arguments for and against the new regulatory institution.
COVID-19 vaccine: vaccinate the young to protect the old?
Authors: Giubilini Alberto , Savulescu Julian , Wilkinson Dominic 
Published: June 2020

Abstract
When we have a vaccine against COVID-19, who should be vaccinated first? The question is relevant because, initially, vaccine availability will likely be limited. After healthcare and some other essential workers, it might seem the most obvious candidates are the elderly and other groups that are more vulnerable to the virus. However, we argue that this is not necessarily the case. Protecting the most vulnerable might require prioritizing vaccinating children in order to maximize the benefits of indirect immunity for the elderly and the other vulnerable groups. Whether this will be the best strategy from a public health perspective will depend on characteristics of the vaccine and of the virus, which are currently unknown. Here, we assess this possibility from an ethical point of view, by drawing comparisons and analogies with the case of the flu vaccination and with other examples of health policies and practices. We conclude that there are strong ethical reasons to vaccinate the young to protect the old, provided that the risks imposed on children are reasonable, even if that implies using children as a means to protect the elderly and the vulnerable.
Species Composition of Anopheles (Diptera: Culicidae) in Selected Forested Tourist Areas of Nigeria Endemic for Malaria
Authors: Oduwole O A , Oringanje C M , Oduola A O , Nwachuku N S , Meremikwu M M , Alaribe A A A 
Published: June 2020

Abstract
The study was carried out to determine relative abundance, species diversity, of Anopheles species (Diptera: Culicidae) in selected forested areas in Cross River State, Nigeria and the prevalence of malaria infection in the specimens. Mosquitoes were collected using pyrethrum spray catch and Centre for Disease Control light traps modified with yeast and sugar to generate carbon dioxide (CO2) and identified using morphological identification keys. We used a multiplex polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) to simultaneously distinguish sibling species of the An. gambiae s.l, including separation of An. gambiae s.s. and An. coluzzii (Diptera: Culicidae). The samples were also screened for Plasmodium infection using the enzyme-linked immunosorbent assay. One hundred and four Anopheles specimens were collected during the study of which 97% was An. gambiae complex and 3% was An. rufipes (Diptera: Culicidae). Only 77% of the An. gambiae s.l. was identify to species level. The result shows that 41.6% was An. gambiae s.s. and 34.6% was An. coluzzii. No sporozoite of Plasmodium was detected in the Anopheles species. The study also found a hybrid form of An. gambiae s.s. and An. coluzzii. These findings suggest the first documented evidence of hybrid forms of An. gambiae s.s./An. coluzzii in South Eastern Nigeria although its epidemiological implication is still not clear.
Magnetic flux density measurements from narrow grain boundaries produced in sintered permanent magnets
Authors: Cho Youngji , Lee Sujin , Murakami Yasukazu 
Published: June 2020

Abstract
This review examines methods of magnetic flux density measurements from the narrow grain boundary (GB) regions, the thickness of which is of the order of nanometers, produced in Nd–Fe–B-based sintered magnets. Despite of the complex crystallographic microstructure and the significant stray magnetic field of the sintered magnet, recent progress in electron holography allowed for the determination of the intrinsic magnetic flux density due to the GB which is embedded in the polycrystalline thin-foil. The methods appear to be useful as well for intensive studies about interface magnetism in a variety of systems.
Promoting Reforestation to Landowners: The Role of Advice-Giving through Information, Efficacy, Narratives, and Identification in Storytelling
Authors: Chung Jennifer H , Sarmiento Irene G , Van Swol Lyn M , Shaw Bret R , Koshollek Alanna , Ahn Paul Hangsan 
Published: June 2020

AbstractAbstractCommunicating reforestation efforts is a challenge for foresters. There are many types of advice to offer, and it is unclear which type of advice is better suited to promote tree-planting behaviors. This study explored the effectiveness of three different types of advice (narrative, informational, and efficacy) for different groups of landowners. We recruited landowners (N = 317) from the Driftless Area of Wisconsin and segmented them into two groups based on their self-reported stage of behavior. They were randomly assigned to view one type of advice message in the form of an online video. Landowners in the early stage of tree-planting behaviors had higher intentions to take the advice with a narrative message. Those in the later stage of behavior were more influenced by informational and efficacy advice messages. We also found that with narrative messages, identification with the narrator was important for increasing intention to use advice.Study Implications: Reforestation is a key component to preserving woodlands and maintaining ecosystems. Professional foresters are tasked with speaking to private woodland owners about this issue and encouraging tree-planting behaviors on their properties. However, not all advice is created equal, and the best type of advice may differ depending on the landowner. The results of this study show that it is important to (1) segment landowners into groups based on previous behaviors and (2) determine the best type of advice for each group. Our analyses found that landowners in Wisconsin’s Driftless Area could be segmented by differences in their current stages of behavior, and different groups responded more strongly to certain types of advice than others. This emphasizes the need for foresters to gain a better understanding of their intended audience rather than considering them as a homogeneous sample. Additionally, foresters can be more effective in advice-giving by creating individualized messages that target specific groups. This approach to advice-giving can be used by foresters to develop better communication strategies for their unique situation with woodland owners.
Understanding (in)tolerance between Hosts and Refugees in Lebanon
Authors: Kheireddine Bassem Jamil , Soares Ana Maria , Rodrigues Ricardo Gouveia 
Published: June 2020

AbstractWith the growth in political, ethnic, and religious conflicts across the globe, intolerance is manifested across different societies especially in the context of (forced) migration and refugees. The purpose of this study is to examine intolerance as a complex social problem. Specifically, this research seeks to explore the perceptions and conceptions of (in)tolerance between refugees from Syria and host communities in Lebanon identifying the degree and the different forms in which tolerance and intolerance materialize. This will allow different agents such as non-governmental organizations (NGOs), policymakers, and relevant authorities to develop adequate interventions to tackle this phenomenon through a social marketing approach and improve (refugee) crisis response plans. The situation has emerged following the Syrian conflict (2011–present) and the arrival of 1.5 million refugees into Lebanon. This number thus constitutes a challenge to both the hosts and the refugees in Lebanon, a small country. A qualitative study was conducted based on semi-structured interviews to investigate the perceptions and conceptions of the target audiences, citizens, refugees, leaders, and NGO staff/volunteers. Results show the existence of a phenomenon of intolerance; its relevant aspects, namely discrimination, prejudice, stereotypes, racism, and scapegoating; and the rise of violence–tension and fear as emerging themes of intolerance manifestations in the context of the Syrian refugee crisis in Lebanon.
De novo adolescent gastric carcinoma: a first case report in Saskatchewan, Canada
Authors: Witt Lara , Pillay Yagan , Sabaratnam Rathi M , Bigsby Richard J 
Published: June 2020

Abstract
Adolescent gastric cancers are extremely rare with a reported incidence of 0.05–0.10% in North America. We present a de novo case of gastric carcinoma in a 17-year-old teenager with no concomitant family history or risk factors. His main clinical presentation included anaemia and melaena stools. Despite an extensive clinical workup that included a diagnostic laparoscopy, the tumour was deemed surgically irresectable, and he was started on a palliative chemotherapy protocol at the local paediatric oncology centre. He demised 7 months later. This is the first recorded case of an adolescent gastric cancer in Saskatchewan, Canada. This case highlights the need for an international tumour registry to document and investigate rare adolescent gastric malignancies and thereby potentiate a possible cure through the pooling of limited resources.
SDSS J124043.01+671034.68: the partially burned remnant of a low-mass white dwarf that underwent thermonuclear ignition?
Authors: Gänsicke Boris T , Koester Detlev , Raddi Roberto , Toloza Odette , Kepler S O 
Published: June 2020

ABSTRACT
The white dwarf SDSS J124043.01+671034.68 (SDSS J1240+6710) was previously found to have an oxygen-dominated atmosphere with significant traces of neon, magnesium, and silicon. A possible origin via a violent late thermal pulse or binary interactions has been suggested to explain this very unusual photospheric composition. We report the additional detection of carbon, sodium, and aluminium in far-ultraviolet and optical follow-up spectroscopy. No iron-group elements are detected, with tight upper limits on titanium, iron, cobalt, and nickel, suggesting that the star underwent partial oxygen burning, but failed to ignite silicon burning. Modelling the spectral energy distribution and adopting the distance based on the Gaia parallax, we infer a low white dwarf mass, $M_\mathrm{wd}=0.41\pm 0.05\, \mathrm{M}_\odot$. The large space velocity of SDSS J1240+6710, computed from the Gaia proper motion and its radial velocity, is compatible with a Galactic rest-frame velocity of ≃ 250 km s−1 in the opposite direction with respect to the Galactic rotation, strongly supporting a binary origin of this star. We discuss the properties of SDSS J1240+6710 in the context of the recently identified survivors of thermonuclear supernovae, the D6 and LP 40−365 stars, and conclude that it is unlikely related to either of those two groups. We tentatively suggest that SDSS J1240+6710 is the partially burned remnant of a low-mass white dwarf that underwent a thermonuclear event.
Impact of dark matter models on the EoR 21-cm signal bispectrum
Authors: Saxena Anchal , Majumdar Suman , Kamran Mohd , Viel Matteo 
Published: June 2020

ABSTRACT
The nature of dark matter sets the timeline for the formation of first collapsed haloes and thus affects the sources of reionization. Here, we consider two different models of dark matter: cold dark matter (CDM) and thermal warm dark matter (WDM), and study how they impact the epoch of reionization (EoR) and its 21-cm observables. Using a suite of simulations, we find that in WDM scenarios, the structure formation on small scales gets suppressed, resulting in a smaller number of low-mass dark matter haloes compared to the CDM scenario. Assuming that the efficiency of sources in producing ionizing photons remains the same, this leads to a lower number of total ionizing photons produced at any given cosmic time, thus causing a delay in the reionization process. We also find visual differences in the neutral hydrogen (H i) topology and in 21-cm maps in case of the WDM compared to the CDM. However, differences in the 21-cm power spectra, at the same neutral fraction, are found to be small. Thus, we focus on the non-Gaussianity in the EoR 21-cm signal, quantified through its bispectrum. We find that the 21-cm bispectra (driven by the H i topology) are significantly different in WDM models compared to the CDM, even for the same mass-averaged neutral fractions. This establishes that the 21-cm bispectrum is a unique and promising way to differentiate between dark matter models, and can be used to constrain the nature of the dark matter in the future EoR observations.
Hydrodynamical instability with noise in the Keplerian accretion discs: modified Landau equation
Authors: Ghosh Subham , Mukhopadhyay Banibrata 
Published: June 2020

ABSTRACT
Origin of hydrodynamical instability and turbulence in the Keplerian accretion disc as well as similar laboratory shear flows, e.g. plane Couette flow, is a long-standing puzzle. These flows are linearly stable. Here we explore the evolution of perturbation in such flows in the presence of an additional force. Such a force, which is expected to be stochastic in nature hence behaving as noise, could be result of thermal fluctuations (however small be), Brownian ratchet, grain–fluid interactions, feedback from outflows in astrophysical discs, etc. We essentially establish the evolution of nonlinear perturbation in the presence of Coriolis and external forces, which is modified Landau equation. We show that even in the linear regime, under suitable forcing and Reynolds number, the otherwise least stable perturbation evolves to a very large saturated amplitude, leading to nonlinearity and plausible turbulence. Hence, forcing essentially leads a linear stable mode to unstable. We further show that nonlinear perturbation diverges at a shorter time-scale in the presence of force, leading to a fast transition to turbulence. Interestingly, emergence of nonlinearity depends only on the force but not on the initial amplitude of perturbation, unlike original Landau equation based solution.
Keeping M-Earths habitable in the face of atmospheric loss by sequestering water in the mantle
Authors: Moore Keavin , Cowan Nicolas B 
Published: June 2020

ABSTRACT
Water cycling between Earth’s mantle and surface has previously been modelled and extrapolated to rocky exoplanets, but these studies neglected the host star. M-dwarf stars are more common than Sun-like stars and at least as likely to host temperate rocky planets (M-Earths). However, M dwarfs are active throughout their lifetimes; specifically, X-ray and extreme ultraviolet (XUV) radiation during their early evolution can cause rapid atmospheric loss on orbiting planets. The increased bolometric flux reaching M-Earths leads to warmer, moister upper atmospheres, while XUV radiation can photodissociate water molecules and drive hydrogen and oxygen escape to space. Here, we present a coupled model of deep-water cycling and water loss to space on M-Earths to explore whether these planets can remain habitable despite their volatile evolution. We use a cycling parametrization accounting for the dependence of mantle degassing on seafloor pressure, the dependence of regassing on mantle temperature, and the effect of water on mantle viscosity and thermal evolution. We assume the M dwarf’s XUV radiation decreases exponentially with time, and energy-limited water loss with 30 per cent efficiency. We explore the effects of cycling and loss to space on planetary water inventories and water partitioning. Planet surfaces desiccated by loss can be rehydrated, provided there is sufficient water sequestered in the mantle to degas once loss rates diminish at later times. For a given water loss rate, the key parameter is the mantle overturn time-scale at early times: if the mantle overturn time-scale is longer than the loss time-scale, then the planet is likely to keep some of its water.
Looking for the underlying cause of black hole X-ray variability in GRMHD simulations
Authors: Bollimpalli D A , Mahmoud R , Done C , Fragile P C , Kluźniak W , Narayan R , White C J 
Published: June 2020

ABSTRACT
Long-term observations have shown that black hole X-ray binaries exhibit strong, aperiodic variability on time-scales of a few milliseconds to seconds. The observed light curves display various characteristic features like a lognormal distribution of flux and a linear rms–flux relation, which indicate that the underlying variability process is stochastic in nature. It is also thought to be intrinsic to accretion. This variability has been modelled as inward propagating fluctuations of mass accretion rate, although the physical process driving the fluctuations remains puzzling. In this work, we analyse five exceptionally long-duration general relativistic magnetohydrodynamic (GRMHD) simulations of optically thin, geometrically thick, black hole accretion flows to look for hints of propagating fluctuations in the simulation data. We find that the accretion profiles from these simulations do show evidence for inward propagating fluctuations below the viscous frequency by featuring strong radial coherence and positive time lags when comparing smaller to larger radii, although these time lags are generally shorter than the viscous time-scale and are frequency-independent. Our simulations also support the notion that the fluctuations in $\dot{M}$ build up in a multiplicative manner, as the simulations exhibit linear rms–mass flux relations, as well as lognormal distributions of their mass fluxes. When combining the mass fluxes from the simulations with an assumed emissivity profile, we additionally find broad agreement with observed power spectra and time lags, including a recovery of the frequency dependency of the time lags.
NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition
Authors: Cui Guofei , Dong Qing , Duan Jiabin , Zhang Chengcheng , Liu Xiao , He Qun 
Published: June 2020

AbstractNegative cofactor 2 (NC2), including two subunits NC2α and NC2β, is a conserved positive/negative regulator of class II gene transcription in eukaryotes. It is known that NC2 functions by regulating the assembly of the transcription preinitiation complex. However, the exact role of NC2 in transcriptional regulation is still unclear. Here, we reveal that, in Neurospora crassa, NC2 activates catalase-3 (cat-3) gene transcription in the form of heterodimer mediated by histone fold (HF) domains of two subunits. Deletion of HF domain in either of two subunits disrupts the NC2α–NC2β interaction and the binding of intact NC2 heterodimer to cat-3 locus. Loss of NC2 dramatically increases histone variant H2A.Z deposition at cat-3 locus. Further studies show that NC2 recruits chromatin remodeling complex INO80C to remove H2A.Z from the nucleosomes around cat-3 locus, resulting in transcriptional activation of cat-3. Besides HF domains of two subunits, interestingly, C-terminal repression domain of NC2β is required not only for NC2 binding to cat-3 locus, but also for the recruitment of INO80C to cat-3 locus and removal of H2A.Z from the nucleosomes. Collectively, our findings reveal a novel mechanism of NC2 in transcription activation through recruiting INO80C to remove H2A.Z from special H2A.Z-containing nucleosomes.