bluuebunny/crossref_metadata_2025_split huggingface dataset:
First known occurrence of the alpheid shrimps Leptalpheus forceps Williams, 1965 and L. marginalis Anker, 2011 (Decapoda: Caridea) in the state of Pará, Amazon region, Brazil
Authors: ROSÁRIO TAYSE N. , PIRES MARCUS A.B. , SOUZA ADELSON S. , FERNANDES MARCUS E.B. , ABRUNHOSA FERNANDO A. , SIMITH DARLAN J.B. 
Published: April 2020

In the present study, we report for the first time the occurrence of the alpheid shrimps Leptalpheus forceps Williams, 1965 and Leptalpheus marginalis Anker, 2011 in the state of Pará, in northern Brazil. Both Leptalpheus species (males, non-ovigerous females, and females carrying eggs) were collected from the burrows of the callichirid “ghost” shrimp, Lepidophthalmus siriboia Felder & Rodrigues, 1993, in a muddy-sandy intertidal zone of the Ajuruteua Peninsula, in the Bragança region. These records update the known geographical distribution of the two species, with L. forceps extending its Brazilian occurrence from the state of Bahia to state of Pará, and L. marginalis which was exclusively found on the Caribbean coast of Colombia is now recorded in Brazil.
The cumacean genus Iphinoe (Crustacea: Peracarida) from Italian waters and I. daphne n. sp. from the northwestern Adriatic Sea, Mediterranean
Authors: MAZZIOTTI CRISTINA , LEZZI MARCO 
Published: April 2020

Records of the cumacean genus Iphinoe from Italian coasts are reported with relevant data on the habitat, morphology and geographical distribution of each species. Seven Iphinoe species from the Italian coasts were recorded and are presented here with their own distributional ranges; the description of a new species, Iphinoe daphne n. sp. is also given. Our results extend the known distribution of some species to new areas of the Mediterranean Sea and suggest that the species Iphinoe adriatica Bâcescu, 1988 can be considered as a nomen dubium, while the presence of I. trispinosa along the Italian coast is doubtful.Finally, a dichotomous key for all Mediterranean Iphinoe species is provided.
Trends and Variations in Concurrent Dispensing of Prescription Opioids and Benzodiazepines in Australia: A Retrospective Analysis
Authors: Islam M. Mofizul , Wollersheim Dennis 
Published: April 2020

Objective: Concurrent use of opioids and benzodiazepines may cause a range of adverse health outcomes including fatal overdose. However, little is known about levels of concurrent use and its variation across jurisdictions. This study examined the population-level prevalence of concurrent use in Australia. Methods: We analyzed a 10% sample of unit record data of prescription opioids and benzodiazepines dispensed between January 2013 and December 2016. Using dispensing dates and days of supply in terms of defined daily dose (DDD), the concurrent users were identified as those for whom the supply in DDD quantity for one medicine overlapped with the supply day of the other. Multivariable and multilevel regression models were developed. Results: During the 4 years, almost a million (12.41% of 7.96 million) individuals were identified as concurrent users. Significantly more women were concurrent users than men across all age groups. On average, 1,750 per 100,000 people were concurrent users per year. There was substantial variation in the yearly average of concurrent users across jurisdictions, ranging from less than 1 to 5,400 per 100,000 people (standardized). Much of this variation was attributed to individual-level circumstances rather than structural factors. Conclusion: Concurrent use of opioid and benzodiazepine was common in Australia. There was considerable variation across jurisdictions in terms of the number of concurrent users. Women, older people, or those living in socioeconomically disadvantaged areas were dominant groups of concurrent users. Further research is needed to examine the precise reasons for concurrent use.
The effects of a supportive-educational intervention on women with type 2 diabetes and diabetic peripheral neuropathy: a randomized controlled trial
Authors: Ahrary Zohre , Khosravan Shahla , Alami Ali , Najafi Nesheli Mahdi 
Published: April 2020

Purpose: To determine the effect of a supportive educational intervention based on the Orem self-care model on women with type 2 diabetes and diabetic peripheral neuropathy. Design: A randomized controlled trial. Setting: Hospital outpatient diabetes clinic. Subjects: Adult women with type 2 diabetes and mild-to-moderate diabetic peripheral neuropathy. Out of 410 patients, 120 diabetic patients were recruited and randomly assigned to trial group ( N = 60) and control group ( N = 60). Intervention: The trial group received a designed intervention consist of one-month supportive educational program with three months of follow-up (totally four months), based on self-care requisites according to the Orem self-care regarding diabetic peripheral neuropathy. The control group only received a routine care program in the diabetes clinic. Main measurements: The main outcomes were symptoms and severity of diabetic neuropathy. Further outcomes were fasting blood sugar and glycosylated hemoglobin. Results: By the end of the intervention, the number of participants reduced from 60 to 58 in the trial group and to 57 in the control group (totally 115). The intervention significantly decreased mean score of diabetic neuropathy symptoms (trial group: 3.26 vs. control group: 9.57, P = 0.001), severity (trial group: 5.86 vs. control group: 9.02, P = 0.001), fasting blood sugar (trial group: 151 vs. control group: 204, P = 0.001), and glycosylated hemoglobin (trial group: 7.85 vs. control group: 8.62, P = 0.004). Conclusion: Delivering a supportive-educational intervention based on the Orem self-care model on outpatient diabetes clinic can decrease the symptoms and severity of diabetic peripheral neuropathy. Trial registration: It was registered in the Iranian Registry of Clinical Trials (IRCT2015021521095N1).
Utility of VSRAD for diagnosing Alzheimer’s disease in patients screened for dementia
Authors: Oshikubo Gaku , Akahane Akihisa , Unno Aki , Watanabe Yukako , Ikebuchi Emi , Tochigi Mamoru , Hayashi Naoki 
Published: April 2020

Objective To investigate the utility of the voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD). Methods Clinical data from patients who underwent screening for dementia using VSRAD and the Japanese version of COGNISTAT, the Neurobehavioral Cognitive Status Examination, were retrospectively investigated to specify the domains of cognitive function that correlate with the statistical mean value of positive Z-scores in the target volume-of-interest (VOI). A receiver operating characteristic (ROC) curve was constructed to assess the mean value of positive Z-scores in discriminating patients with AD. Results A total of 72 patients were included (18 male and 54 female; 15 patients with AD). The mean value of positive Z-scores in the target VOI was significantly correlated with standardized COGNISTAT scores for Orientation and Memory in all patients (r = –0.35 and –0.38, respectively). ROC curve analysis revealed that a cut-off of 1.57 for mean value of positive Z-scores in the target VOI provided 69.4% accuracy in discriminating patients with AD, with a sensitivity of 0.80 and specificity of 0.67. Conclusions The results evinced the value of VSRAD in diagnosing AD. The degree of atrophy represented by the target VOI may reflect impairments in Orientation and Memory, which are early stage symptoms observed in AD.
Initial design of low-thrust trajectories based on the Bezier curve-based shaping approach
Authors: Fan Zichen , Huo Mingying , Qi Naiming , Zhao Ce , Yu Ze , Lin Tong 
Published: April 2020

This paper presents a method to use the Bezier curve to rapidly generate three-dimensional low-thrust trajectories, which can provide a suitable initial approximation to be used for more accurate trajectory optimal control tools. Two missions, from Earth to Mars and the asteroid Dionysus, are considered to evaluate the performance of the method. In order to verify the advantages of this method, it is compared with the finite Fourier series method. Numerical results show that the Bezier method can get better performance index in shorter computation time compared with the finite Fourier series method. The applicability of the solution obtained by Bezier method is evaluated by introducing the obtained solution into the Gauss pseudospectral method as an initial guess. The simulation results show that the Bezier method can rapidly generate a very suitable three-dimensional initial trajectory for the optimal solver. This is very important for rapid evaluation of the feasibility of a large number of low-thrust flight schemes in the preliminary mission design stage.
Professional Wargaming: A Flawed but Useful Tool
Authors: Curry John 
Published: April 2020

Rationale for the Article. Professional wargames have long been an integral part of the tool set used by the military. The literature includes many examples of wargames that have been successful in terms of training, military education, procurement, operational analysis and planning for war. However, retrospective examination demonstrates that many of these professional wargames also had major errors in them and by implication current games about future confrontations are similarly flawed. Nevertheless, the academic evidence is clear that such games are still invaluable tools. Methodology. Ten years of research into the development of wargames undertaken by the History of Wargaming Project has analysed and made generally available more professional wargames than ever before. Retrospective examination of a sample of these declassified games, from the British War Office Rules (1896) to more recent games about the Ukraine, shows significant errors. Value. Demonstrating that professional games had errors in the past opens challenges the overconfidence in the predictive capacity of games. It also raises the possibility for future research to identify game design bias and to develop better games in the future. Understanding the value of better games, even with their inherent issues, raise the possibility of better preparing decision makers for the future. Notes. The words wargame and game are used interchangeably in this article. Whilst the techniques used in professional gaming evolved from modelling the battlefield, modern professional gaming is increasingly focussed on other situations that are not war, such as state level confrontations, trade wars, politics, cyber conflict, banking crisis etc. Using the term wargame seems inappropriate when for example, gaming a shipping dispute. All the games referred to this article, unless otherwise noted, are professional wargames, used by military, government, public sector bodies and other parties directly involved in real world issues. The prefix professional has been omitted for brevity in most places.
Caring experiences of family caregivers of patients with heart failure: A meta-ethnographic review of the past 10 years
Authors: Kim Eun Young , Oh Seieun , Son Youn-Jung 
Published: April 2020

Background: Living with heart failure, a debilitating disease with an unpredictable course, requires ongoing adaptation and management not only from patients but also from their families. Family caregivers have been known to be key facilitators of self-management of heart failure. An integrative understanding of the experiences of family caregivers will provide essential information for improving the quality of life of persons with heart failure and their families. Aims: This study aimed to integrate and synthesize the findings of qualitative studies on family members’ experiences of caring for patients with heart failure. Methods: We employed the meta-ethnography methodology. Five electronic bibliographic databases were used to retrieve studies published from April 2009–March 2019 that explored family caregivers’ experiences of caring for patients with heart failure. Twelve qualitative studies were finally included for the synthesis, based on the eligibility criteria. Results: Three themes were identified: “shouldering the entire burden,” “starting a new life,” and “balancing caregiving and everyday life.” These three themes illustrate how family caregivers fulfilled caregiving roles, what helped them juggle their multiple responsibilities, and how they struck a balance between life as caregivers and individuals in their own right. Conclusion: This review provides a deeper understanding of family caregivers’ experiences of caring for patients with heart failure. The findings can help healthcare providers in the development and implementation of tailored interventions for both patients and family caregivers.
Pain and load progression following an early maximal strength training program in total hip- and knee arthroplasty patients
Authors: Winther Siri B , Foss Olav A , Klaksvik Jomar , Husby Vigdis S 
Published: April 2020

Purpose: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients significantly increase muscle strength after maximal strength training (MST) initiated soon after surgery. Owing to severe postoperative pain, knee patients are anticipated to be more limited in performing heavy load exercises than hip patients. The aim of the present study was to describe pain and load progression during early MST in THA and TKA patients. Methods: Explorative study based on secondary analyses from two randomized controlled trials: 26 THA and 16 TKA patients had their training sessions logged. They trained at 85–90% of their maximal capacity in leg press, and abduction/knee-extension of the operated leg (4 × 5 repetitions) for 8–10 weeks, initiated early postoperatively. Results: Knee patients experienced significantly more pain than hip patients during the training sessions ( p < 0.03), however, pain before and after training was not different ( p > 0.09). All patients significantly increased leg press training load until the last intervention week ( p < 0.01). Conclusion: This study demonstrates that TKA patients experience more pain than THA patients during training following a MST program but not more than moderate levels during or after training. Pain before and after training is not different. Both groups significantly increased load progression during the intervention. These findings indicate that both THA and TKA patients might perform MST with extensive load progression early after surgery without compromising pain. The studies were registered at ClinicalTrials.gov .
Clinical characteristics, management, and outcome of incidental pulmonary embolism in cancer patients
Authors: Qdaisat Aiham , Kamal Mona , Al-Breiki Aisha , Goswami Biman , Wu Carol C. , Zhou Shouhao , Rice Terry W. , Alagappan Kumar , Yeung Sai-Ching Jim 
Published: April 2020

Abstract
Incidental pulmonary embolisms (IPEs) are common in cancer patients. Examining the characteristics and outcomes of IPEs in cancer patients can help to ensure proper management, promoting better outcomes. To determine the clinical characteristics, management, and outcomes of IPEs for cancer patients, we conducted a 1:2 ratio case-control study and identified all consecutive patients with IPE who visited the emergency department at The University of Texas MD Anderson Cancer Center between 1 January 2006 and 1 January 2016. Each IPE case was matched with 2 controls using a propensity score obtained using logistic regression for IPE status with other factors affecting overall survival. A total of 904 confirmed cases were included in the analysis. IPE frequently occurred during the first year after cancer diagnosis (odds ratio [OR], 2.79; 95% confidence interval [95% CI], 2.37-3.29; P &lt; .001). Patients receiving cytotoxic chemotherapy had a nearly threefold greater risk of developing IPE (OR, 2.87; 95% CI, 2.42-3.40; P &lt; .001). In-hospital mortality was 1.9%. The 7- and 30-day mortality rates among the cases were 1.8% and 9.9%, respectively, which was significantly higher than in the control groups: 0.2% and 3.1%, respectively (P &lt; .001). IPE was associated with reduced overall survival (hazard ratio [HR], 1.93; 95% CI, 1.74-2.14; P &lt; .001). Concurrent incidental venous thromboembolism was identified in 189 of the patients (20.9%) and was also associated with reduced overall survival (HR, 1.65; 95% CI, 1.21-2.25; P = .001). Our results show that IPE events are associated with poor outcomes in cancer patients. Proper management plans similar to those of symptomatic pulmonary embolisms are essential.
Facile Approach to Prepare rGO@Fe3O4 Microspheres for the Magnetically Targeted and NIR-responsive Chemo-photothermal Combination Therapy
Authors: Liang Chunyong , Song Jiying , Zhang Yongguang , Guo Yaping , Deng Meigui , Gao Wei , Zhang Jimin 
Published: April 2020

AbstractNear-infrared (NIR)-light responsive graphene have been shown exciting effect on cancer photothermal ablation therapy. Herein, we report on the preparation of Fe3O4-decorated hollow graphene microspheres (rGO@Fe3O4) by a facile spray drying and coprecipitation method for the magnetically targeted and NIR-responsive chemo-photothermal combination therapy. The microspheres displayed very high specific surface area (~ 120.7 m2 g−1) and large pore volume (~ 1.012 cm3 g−1), demonstrating distinct advantages for a high loading capacity of DOX (~ 18.43%). NIR triggered photothermal effect of the rGO@Fe3O4microspheres responded in an on-off manner and induced a high photothermal conversion efficiency. Moreover, The Fe3O4on the microspheres exhibited an excellent tumor cells targeting ability. The chemo-photothermal treatment based on rGO@Fe3O4/DOX showed superior cytotoxicity towards Hela cells in vitro. Our studies indicated that rGO@Fe3O4/DOX microcapsules have great potential in combined chemo-photothermal cancer treatment.
Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans
Authors: Li Jinheng , Wu Tiantian , Peng Weiwei , Zhu Yaqin 
Published: April 2020

Abstract
Background
Streptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans.

Results
Resveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol.

Conclusions
Resveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis
Authors: Loan James J. M. , Poon Michael T. C. , Tominey Steven , Mankahla Ncedile , Meintjes Graeme , Fieggen A. Graham 
Published: April 2020

Abstract
Background
Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal shunt (VPS). In HIV-infected patients there is concern that VPS might be associated with unacceptably high mortality. To identify prognostic indicators, we aimed to compare survival and clinical outcome following VPS placement between all studied causes of hydrocephalus in HIV infected patients.

Methods
The following electronic databases were searched: The Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), EMBASE, CINAHL Plus, LILACS, Research Registry, the metaRegister of Controlled Trials, ClinicalTrials.gov, African Journals Online, and the OpenGrey database. We included observational studies of HIV-infected patients treated with VPS which reported of survival or clinical outcome. Data was extracted using standardised proformas. Risk of bias was assessed using validated domain-based tools.

Results
Seven Hunderd twenty-three unique study records were screened. Nine observational studies were included. Three included a total of 75 patients with tuberculous meningitis (TBM) and six included a total of 49 patients with cryptococcal meningitis (CM). All of the CM and two of the TBM studies were of weak quality. One of the TBM studies was of moderate quality. One-month mortality ranged from 62.5–100% for CM and 33.3–61.9% for TBM. These pooled data were of low to very-low quality and was inadequate to support meta-analysis between aetiologies. Pooling of results from two studies with a total of 77 participants indicated that HIV-infected patients with TBM had higher risk of one-month mortality compared with HIV non-infected controls (odds ratio 3.03; 95% confidence-interval 1.13–8.12; p = 0.03).

Conclusions
The evidence base is currently inadequate to inform prognostication in VPS insertion in HIV-infected patients. A population-based prospective cohort study is required to address this, in the first instance.
Household food insecurity associated with gestacional and neonatal outcomes: a systematic review
Authors: Augusto Ana Lucia Pires , de Abreu Rodrigues Aléxia Vieira , Domingos Talita Barbosa , Salles-Costa Rosana 
Published: April 2020

AbstractBackgroundFood insecurity (FI) occurs when people lack secure access to sufficient amounts of safe and nutritious food. FI has been associated with negative effects on human health, including during the prenatal and neonatal periods. The objective of this study is to evaluate the consequences of FI for pregnant women’s and newborns’ health.MethodsA literature search was performed with three independent researchers based on the PRISMA guidelines; the search covered the period of November 2008 to July 2019 and was conducted in the following databases: the US National Library of Medicine at the National Institutes of Health (PubMed), Latin American and Caribbean Health Sciences (LILACS), Cochrane Library, Web of Science, Embase, Scopus and OpenGrey. The terms and descriptors were defined by consulting the Medical Subject Headings (MeSH) and Health Sciences Descriptors (DeCS) platforms and mainly included “food security”, “food insecurity”, “pregnancy” and “newborn”. The studies were selected through a title and abstract review and then a reading of the full text. The quality of the studies and the risk of bias were analysed based on the criteria defined in the “Joanna Briggs Institute Reviewers’ Manual” and by Guyatt and colleagues for interventional studies. The population, study design, FI measurement instruments, FI proportions, outcomes, confounders and results were extracted from the 37 studies that were selected according to the eligibility and quality criteria.ResultsFI ​​proportions ranged from 5.2 to 87%. Most studies were conducted with African populations (42.2%) and applied globally used scales to assess FI (56.7%); 27% of the studies adapted scales. There were wide variations in the instruments used to estimate FI. The main outcomes related to FI included stress, anxiety and depression during pregnancy, followed by dietary quality and dietary diversity. Associations of FI with birth defects, neonatal mortality and the early introduction of animal milk to the infant’s diet were also observed.ConclusionsIt is necessary to pay attention to the diversity of FI measurement instruments before FI results are compared. FI can be a risk factor for depression and stress during pregnancy, as well as for neonatal mortality, newborn health problems and breastfeeding interruption.Trial registrationThis systematic review was registered on PROSPERO (CRD42018109478).