bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting ion dynamics through superwettable leaf-like film based on porous g-C3N4 nanosheets for ionogel supercapacitors
Authors: Shi Minjie , Yang Cheng , Yan Chao , Jiang Jintian , Liu Yongchao , Sun Zhenyu , Shi Weilong , Jian Gang , Guo Zhanhu , Ahn Jong-Hyun 
Published: October 2019

AbstractIonic liquid (IL) electrolytes have enormous potential for the development of high energy density supercapacitors (SCs) owing to their wide potential windows, but ILs are plagued by sluggish ionic diffusion due to their high viscosity and large ion size. Exploiting superwettable electrodes possessing high compatibility with IL electrolytes remains challenging. Inspired by the biological characteristics observed in nature, a unique film electrode with a Monstera leaf-like nanostructure is synthesized and used to overcome the aforementioned bottleneck. Similar to the pores in Monstera leaves that allow the permeation of air and water vapor, the film electrode is based on porous g-C3N4 nanosheets (~1 nm thick) as ion-accessible “highway” channels, allowing ultrafast diffusion of IL ions. The film exhibits a high diffusion coefficient (3.68 × 10−10 m2 s−1), low activation energy (0.078 mJ mol−1) and extraordinary wettability in the IL electrolyte, indicating its superior IL ion dynamics. As a proof of concept, flexible ionogel SCs (FISCs) with tailorability and editability are fabricated, which exhibit a high energy density (10.5 mWh cm−3), high-power density, remarkable rate capability, and long-term durability, outperforming previously reported FISCs. Importantly, these FISCs can be effectively charged by harvesting sustainable power sources, particularly the rarely studied wind power, for practical applications.
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
Authors: Danielsson Marcus , Halvardson Jonatan , Davies Hanna , Torabi Moghadam Behrooz , Mattisson Jonas , Rychlicka-Buniowska Edyta , Jaszczyński Janusz , Heintz Julia , Lannfelt Lars , Giedraitis Vilmantas , Ingelsson Martin , Dumanski Jan P. , Forsberg Lars A. 
Published: October 2019

AbstractMosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is associated with increased risk for all-cause mortality, various forms of cancer and Alzheimer’s disease, as well as other common human diseases. By tracking LOY frequencies in subjects from which blood samples have been serially collected up to five times during up to 22 years, we observed a pronounced intra-individual variation of changes in the frequency of LOY within individual men over time. We observed that in some individuals the frequency of LOY in blood clearly progressed over time and that in other men, the frequency was constant or showed other types of longitudinal development. The predominant method used for estimating LOY is calculation of the median Log R Ratio of probes located in the male specific part of chromosome Y (mLRRY) from intensity data generated by SNP-arrays, which is difficult to interpret due to its logarithmic and inversed scale. We present here a formula to transform mLRRY-values to percentage of LOY that is a more comprehensible unit. The formula was derived using measurements of LOY from matched samples analysed using SNP-array, whole genome sequencing and a newAMELX/AMELY-based assay for droplet digital PCR. The methods described could be applied for analyses of the vast amount of SNP-array data already generated in the scientific community, allowing further discoveries of LOY associated diseases and outcomes.
Complications associated with perioperative use of tyrosine kinase inhibitor in cytoreductive nephrectomy
Authors: Carvalho Filipe L. F. , Zheng Chaoyi , Witmer Kenneth , O’neill John , Lynch John H. , Kowalczyk Keith J. 
Published: October 2019

AbstractRecent clinical trials have investigated the benefit of combining tyrosine kinase inhibitors (TKIs) and cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma. Our goal is to determine whether the perioperative use of TKIs increases the postoperative morbidity following CN in renal cell carcinoma patients. We identified 627 patients with Stage IV renal cell carcinoma who underwent CN from 2007–2010 utilizing the SEER-Medicare database. Eighty-two patients treated with TKIs were matched (3:1) to 246 controls. We calculated 30- and 90-day incidence rates of postoperative complications and mortality. On unadjusted analysis, TKI use prior to CN was associated with higher overall complication rate within 30 days (HR = 2.73, 95% CI: 1.09–6.8) after surgery. On multivariate analysis, perioperative TKI use was independently associated with higher risk for postoperative complications within 30 days (HR = 2.93, 95% CI: 1.17–7.36), as well as 90 days (HR = 1.84, 95% CI: 1.02–3.32) after nephrectomy. A higher Charlson comorbidity index also emerged to represent an independent risk factor for postoperative complications within 30 days (HR = 2.41, 95% CI: 1.44–4.02) and 90 days (HR = 2.23, 95% CI: 1.51–3.29) after nephrectomy. TKI treatment was not associated with an increased postoperative mortality at 30 and 90 days after surgery. Thus, TKI treatment was associated with an increased complication rate but not overall mortality following CN. Our results suggest that renal surgeons should be aware of possibly increased complications following CN in renal cell carcinoma patients, when TKI treatment is administered.
Structural Dynamics of the N-Extension of Cardiac Troponin I Complexed with Troponin C by Site-Directed Spin Labeling Electron Paramagnetic Resonance
Authors: Zhao Chenchao , Somiya Takayasu , Takai Shinji , Ueki Shoji , Arata Toshiaki 
Published: October 2019

AbstractThe secondary structure of the N-extension of cardiac troponin I (cTnI) was determined by measuring the distance distribution between spin labels attached to the i and i + 4 residues: 15/19, 23/27, 27/31, 35/39, and 43/47. All of the EPR spectra of these regions in the monomeric state were broadened and had a amplitude that was reduced by two-thirds of that of the single spin-labeled spectra and was fit by two residual distance distributions, with a major distribution one spreading over the range from 1 to 2.5 nm and the other minor peak at 0.9 nm. Only slight or no obvious changes were observed when the extension was bound to cTnC in the cTnI-cTnC complex at 0.2 M KCl. However, at 0.1 M KCl, residues 43/47, located at the PKC phosphorylation sites Ser42/44 on the boundary of the extension, exclusively exhibited a 0.9 nm peak, as expected from α-helix in the crystal structure, in the complex. Furthermore, 23/27, which is located on the PKA phosphorylation sites Ser23/24, showed that the major distribution was markedly narrowed, centered at 1.4 nm and 0.5 nm wide, accompanying the spin label immobilization of residue 27. Residues 35 and 69 at site 1 and 2 of cTnC exhibited partial immobilization of the attached spin labels upon complex formation. The results show that the extension exhibited a primarily partially folded or unfolded structure equilibrated with a transiently formed α-helix-like short structure over the length. We hypothesize that the structure binds at least near sites 1 and 2 of cTnC and that the specific secondary structure of the extension on cTnC becomes uncovered when decreasing the ionic strength demonstrating that only the phosphorylation regions of cTnI interact stereospecifically with cTnC.
C-terminal–modified LY2510924: a versatile scaffold for targeting C-X-C chemokine receptor type 4
Authors: Suzuki Kentaro , Ui Takashi , Nagano Akio , Hino Akihiro , Arano Yasushi 
Published: October 2019

AbstractC-X-C chemokine receptor type 4 (CXCR4) constitutes a promising target for tumor diagnosis and therapy. Herein, we evaluate a new 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated CXCR4 antagonist derived from LY2510924, FRM001, and its metal complexes as CXCR4-targeting probes. FRM001 was synthesized by modifying the C-terminus of LY2510924 with maleimido-mono-amide-DOTA via a cysteine linker. FRM001 exhibited CXCR4-specific binding with an affinity similar to that of the parental LY2510924. The binding affinity of FRM001 remained unchanged after complexation with Ga, Lu, and Y. The internalization of 67Ga-FRM001 into the cells was hardly observed. In mice biodistribution studies, 67Ga-FRM001 exhibited high accumulation in the tumor and the liver with rapid elimination rates from the blood. The hepatic accumulation of 67Ga-FRM001 was preferentially and significantly reduced by co-injecting a CXCR4 antagonist, AMD3100. The C-terminal–modified LY2510924 would constitute a versatile scaffold to develop CXCR4-targeting probes or therapeutics for tumor imaging or therapy.
Changing patterns and influencing factors of involuntary admissions following the implementation of China’s mental health law: A 4-year longitudinal investigation
Authors: Ma Hua-Jian , Xie Bin , Shao Yang , Huang Jing-Jing , Xiao Ze-Ping 
Published: October 2019

AbstractInvoluntary admission (IA) is limited to particular situations in mental health laws to protect patients from unnecessary coercion. China’s first national mental health law has been in effect since 2013; however, the status of IA has not been sufficiently explored. To explore the changing patterns of IA since the clinical application of the IA criteria specified in the new law, an investigation of IA status was undertaken in 14 periods (each period lasting for one month from 05/2013 to 05/2017) in the tertiary specialized psychiatric hospital in Shanghai. The socio-demographic and clinical characteristics of 3733 patients were collected. The differences among IA rates in different periods were compared, and the characteristics of patients who were and were not involuntarily admitted were analysed. Multiple logistic regression analysis was used to clarify the independent variables of IA. The IA rate dramatically decreased after the implementation of the new law, while the overall trend gradually increased. The implementation of the IA risk criteria is effective, but IA is still common in China. The medical factors influencing IA following the implementation of the new law are similar to those in previous studies at home and abroad. Non-medical factors might be the main causes of the high IA rates in Chinese psychiatric institutions.
A Systematically Conducted Scoping Review of the Evidence and Fidelity of Treatments for Verb Deficits in Aphasia: Verb-in-Isolation Treatments
Authors: Hickin Julie , Cruice Madeline , Dipper Lucy 
Published: October 2019

PurposeAphasia research demonstrates increasing interest in the treatment of verb retrieval deficits. This systematically conducted scoping review reports on the level and fidelity of the current evidence for verb treatments; on its effectiveness regarding the production of trained and untrained verbs, functional communication, sentences, and discourse; and on the potential active ingredients. Recommendations to guide clinical decision making and future research are made.MethodThe computerized database search included studies from January 1980 to September 2018. The level of evidence of each study was documented, as was fidelity in terms of treatment delivery, enactment, and receipt. Studies were also categorized according to the treatment methods used.ResultsThirty-seven studies were accepted into the review, and all but 1 constituted a low level of evidence. Thirty-three studies (89%) described treatment in sufficient detail to allow replication, dosage was poorly reported, and the fidelity of treatment was rarely assessed. The most commonly reported treatment techniques were phonological and semantic cueing in 25 (67.5%) and 20 (54%) studies, respectively. Retrieval of trained verbs improved for 80% of participants, and improvements generalized to untrained verbs for 15% of participants. There was not sufficient detail to evaluate the impact of treatment on sentence production, functional communication, and discourse.ConclusionsThe evidence for verb treatments is predominantly of a low level. There are encouraging findings in terms of treatments being replicable; however, this is tempered by poor monitoring of treatment fidelity. The quality of verb treatment research would be improved by researchers reaching consensus regarding outcome measures (including generalization to, e.g., sentences and discourse) by manualizing treatment to facilitate implementation and exploring the opinions of participants. Finally, while treatment is largely effective in improving production of trained verbs, lack of generalization to untrained items leads to the recommendation that personally relevant verbs are prioritized.
Exploring Associations Between a Biological Marker of Chronic Stress and Reported Depression and Anxiety in People With Aphasia
Authors: Pompon Rebecca Hunting , Smith Alissa N. , Baylor Carolyn , Kendall Diane 
Published: October 2019

Purpose
Living with the communication impairment of aphasia can be stressful. Chronic stress, depression, and anxiety are intimately linked, may be more pervasive in people with poststroke aphasia than the general population, and may influence cognitive function and treatment outcomes. In this project, we explored the psychological constructs of depression and anxiety and their associations with a biomarker measure of chronic stress in people with aphasia.

Method
Fifty-seven participants with aphasia completed measures of depression and anxiety and provided a hair sample from which to extract the stress hormone cortisol. Pearson product–moment correlational analyses were used to identify associations between depression, anxiety, and long-term level of cortisol via hair sample.

Results
While cortisol level was not associated with depression and anxiety across this sample of people with aphasia, a post hoc analysis showed a significant, positive correlation between a subset of participants with moderate and higher levels of depression and elevated cortisol level.

Conclusions
Chronic stress, depression, and anxiety have been little explored in people with aphasia to date, yet they are associated with future health consequences and impaired cognitive function, motivating further research as well as consideration of these factors in aphasia rehabilitation.
ChandraCOSMOS Legacy Survey: Clustering dependence of Type 2 active galactic nuclei on host galaxy properties
Authors: Allevato V. , Viitanen A. , Finoguenov A. , Civano F. , Suh H. , Shankar F. , Bongiorno A. , Ferrara A. , Gilli R. , Miyaji T. , Marchesi S. , Cappelluti N. , Salvato M. 
Published: October 2019

Aims.We perform clustering measurements of 800 X-ray selectedChandraCOSMOS Legacy (CCL) Type 2 active galactic nuclei (AGN) with known spectroscopic redshift to probe the halo mass dependence on AGN host galaxy properties, such as galaxy stellar massMstar, star formation rate (SFR), and specific black hole accretion rate (BHAR;λBHAR) in the redshift rangez = [0−3].Methods.We split the sample of AGN with known spectroscopic redshits according toMstar, SFR andλBHAR, while matching the distributions in terms of the other parameters, including redshift. We measured the projected two-point correlation functionwp(rp) and modeled the clustering signal, for the different subsamples, with the two-halo term to derive the large-scale biasband corresponding typical mass of the hosting halo.Results.We find no significant dependence of the large-scale bias and typical halo mass on galaxy stellar mass and specific BHAR for CCL Type 2 AGN at meanz ∼ 1, while a negative dependence on SFR is observed, i.e. lower SFR AGN reside in richer environment. Mock catalogs of AGN, matched to have the same X-ray luminosity, stellar mass,λBHAR, and SFR of CCL Type 2 AGN, almost reproduce the observedMstar − Mh,λBHAR − Mhand SFR–Mhrelations, when assuming a fraction of satellite AGNfAGNsat∼ 0.15. This corresponds to a ratio of the probabilities of satellite to central AGN of being activeQ ∼ 2. Mock matched normal galaxies follow a slightly steeperMstar − Mhrelation, in which low mass mock galaxies reside in less massive halos than mock AGN of similar mass. Moreover, matched mock normal galaxies are less biased than mock AGN with similar specific BHAR and SFR, at least forQ >  1.
Interprofessionelle Zusammenarbeit von OP- und Anästhesie-Pflege
Authors: Hipler Annette 
Published: October 2019

ZusammenfassungIn der interprofessionellen Zusammenarbeit im OP liegt die Zukunft. Allerdings zeigt sich aktuell nur eine rudimentär ausgebildete, teambasierte Arbeit. Deshalb hat unsere Autorin die pflegenden Mitarbeiter im OP befragt: Wie sieht die Realität im OP aus? Was muss sich verändern? Welche Erwartungen haben die „befreundeten Fachrichtungen“ an OP-Pflegende?
Validated LC-MS/MS Method for Simultaneous Quantitation of Enasidenib and its Active Metabolite, AGI-16903 in Small Volume Mice Plasma: Application to a Pharmacokinetic Study
Authors: Dittakavi Sreekanth , Hallur Gurulingappa , Purra Buchi Reddy , Kiran Vinay , Zakkula Ashok , Mullangi Ramesh 
Published: October 2019

AbstractEnasidenib is a selective mutant isocitrate dehydrogenase 2 inhibitor approved for the treatment of relapsed and refractory acute myeloid leukemia patients. A sensitive and rapid method has been developed and validated as per regulatory guideline for the simultaneous quantitation of enasidenib and its active metabolite, AGI-16903 in mice plasma using an LC-MS/MS. Enasidenib and AGI-16903 along with internal standard were extracted from mice plasma using simple protein precipitation method. Chromatographic resolution of enasidenib, AGI-16903 and the internal standard (close analogue of AGI-16903) was achieved on a Chromolith RP-18e column using 0.2% formic acid:acetonitrile (15:85, v/v) as an eluent, which was delivered at a flow-rate of 1.2 mL/min. The MS/MS ion transitions monitored were m/z 474.1→267.2, 402.1→188.1 and 421.0→146.1 for enasidenib, AGI-16903 and the internal standard, respectively. The linearity range was 1.01–3023 ng/mL for both enasidenib and AGI-16903. The within-run and between-run accuracy and within-run and between-run precision were in the range of − 2.29 to 2.72 (as one value is in negative side). and 4.65–9.82%, respectively for enasidenib; 0.19–10.3 and 3.22–9.22%, respectively for AGI-16903. Both enasidenib and AGI-16903 were found to be stable in stability (up to three freeze-thaw cycles and for long-term at −80°C for 30 days) and processed (bench-top for 6 h and in in-injector for 24 h) samples. Application of the validated method was shown in a pharmacokinetic study in mice.
Isolated Superior Cerebellar Vermis Injury: A Consequence of Hypoxic Ischemic Injury
Authors: Joshi Hiten , Mordekar Santosh R. , Connolly Daniel J.A. , Griffiths Paul D. 
Published: October 2019

AbstractHypoxic ischemic insult in early childhood can have a varied clinical presentation depending on the timing and severity of the insult, and magnetic resonance imaging plays a key role in identifying injury patterns. Dyskinetic cerebral palsy is commonly associated with injury to the basal ganglia and thalamus. We report two cases presenting in early childhood with signs and symptoms of dyskinetic cerebral palsy attributed to focal damage to the superior cerebellar vermis secondary to a hypoxic insult in the perinatal period in term infants.
Analysing seed endophytes for biotechnology.
Authors: Bergna A. , Cernava T. , Zachow C. , Berg G. 
Published: October 2019

Abstract

Seed endophytes play a crucial role during the entire life cycle of plants due to their ability to promote germination and plant growth and provide defence against biotic and abiotic stress. The increasing interest related to these microorganisms for applications in sustainable agriculture requires the use of a wide spectrum of techniques to investigate their ecological role and to exploit their biotechnological potential. While the isolation of microorganisms is the most straightforward method to characterize and select microorganisms, molecular techniques represent an advantageous option for the discovery and tracking of uncultivable microbial species. This chapter shows that the concomitant employment of cultivation-dependent and cultivation-independent techniques represents the most sophisticated approach for the study of endophytic communities. In addition to a general assessment of developments in this field, the most frequently used tools are described in detail. Moreover, their possible integration as shown in various studies targeting seed endophytes is highlighted. We expect that novel products for biotechnology will become more feasible in the future due to the recent technological and methodological developments.
Prospects for biotechnological exploitation of endophytes using functional metagenomics.
Authors: Obermeier M. M. , Bogotá C. A. M. 
Published: October 2019

Abstract

The usage of natural products, especially in the treatment of diseases, has a long history. While natural products used to be administered directly, they today serve as lead compounds and structural scaffolds for the development of new drugs and other market products. The success of combinatorial approaches to develop new products strongly depends on natural product-likeness. This exemplifies the importance of natural products as structural leads during product development and demonstrates natural product discovery to be as important as ever. This chapter highlights endophytes as a rich bio-resource for the identification of novel natural compounds and emphasizes functional metagenomics as a promising method to source the endophytic potential. With the majority of microorganisms not readily cultivable under laboratory conditions, a vast amount of natural products synthesized by endophytes remains inaccessible. Functional metagenomics circumvents current cultivation limitations by direct cloning of bacterial community DNA. This procedure is, however, rarely performed exclusively on endophytes. This chapter outlines the procedures underlying this methodology with focus on its application to endophytes.
Interplay between endophyte and host plant in the synthesis and modification of metabolites.
Authors: Ludwig-Müller J. 
Published: October 2019

Abstract

The interplay between plants and microbes in their contribution of secondary metabolite synthesis is still not well understood. While plant pathogens might contribute by the synthesis of toxic compounds and the host by making antimicrobial compounds, the synthesis of secondary metabolites in the interaction of plants with endophytic organisms might be much more sophisticated. One possibility is that the plant makes antimicrobial compounds that are either sequestered or metabolized by the endophytic organisms. Alternatively, the inhabitant makes compounds that are released into the plant or environment for its own benefit. Such a compound can also be altered biochemically by the host. Finally, the two partners can contribute to one pathway by using an intermediate synthesized by one and later made to another compound by the other partner. Such examples and the implication for future research to identify the organisms mainly responsible for the biosynthetic pathways are discussed in this chapter.