bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of serum Mrp 8/14 in sepsis-induced acute respiratory distress syndrome patients: a retrospective cohort study
Authors: Sun Caizhi , Xie Yongpeng , Zhu Chenchen , Guo Lei , Xu Bowen , Qin Haidong , Li Xiaomin 
Published: December 2024

Background
Mrp 8/14 is abundantly secreted by activated neutrophils during infection and inflammation. However, its prognostic value in acute respiratory distress dyndrome (ARDS) induced by sepsis is poorly understood. Our aim was to investigate the relationship between serum Mrp 8/14 and the prognosis in sepsis-induced ARDS patients admitted to the intensive care unit (ICU).

Methods
Serum Mrp 8/14 concentrations were analyzed in 118 ARDS patients induced by sepsis included in the analytical study. Patients were enrolled upon admission to the ICU of Nanjing Hospital affiliated to Nanjing Medical University. The baseline information and clinical outcomes were obtained. Patients were divided into survivor group and non-survivor group according to whether they died during ICU hospitalization.

Results
The serum Mrp 8/14 levels were significantly increased in the non-survivor group compared to the survivor group (P < 0.05). Logistic regression analysis showed that serum Mrp 8/14, albumin and APACHE II were the independent factors for predicting the prognosis of sepsis-induced ARDS during ICU hospitalization after adjustment. Additionally, the area under the receiver operating characteristic curve for Mrp 8/14 combined with albumin was associated with ICU mortality and was higher than that of Mrp 8/14, albumin, APACHE II and Mrp 8/14 combined with APACHE II (all P < 0.05). A nomogram was constructed to predict ICU mortality and the c-indexes of predictive accuracy was 0.830 in the cohort (P < 0.05).

Conclusions
The serum Mrp 8/14 upon ICU admission in septic patients may be useful for predicting mortality in sepsis-induced ARDS patients during ICU hospitalization.
The Effect of the Project-Based Seamless Learning Model on Critical Thinking of Prospective Early Childhood Education Educator Students
Authors: Vicy  , Mustaji  , Mariono Andi , Arianto Fajar 
Published: December 2024

Aims: The aim of this study was to identify the effect of the project-based seamless learning model on critical thinking of prospective early childhood education educator students.
Study Design: The research used quantitative experimental design.
Methodology: The method used quasi experiment with research design nonequivalent pretest posttest group design, where there is an experimental group and a control group, the experimental group is given treatment and there is no treatment on the control group. The research subjects were 150 students, 75 students in the experimental group and 75 students in the control group. Data collection using tests conducted pretest and posttest. project-based seamless learning model on critical thinking skills of prospective educator students. Based on the results of hypothesis testing on the posttest, the value on the posttest of the experimental group and the control group obtained a significance value of 0.001 <0.050. And also the difference in the average value of the experimental group's posttest of 84.20, greater than the lower control group of 80.40. This proves that there are differences caused by the application of learning models in the two groups. The experimental group used a project-based seamless learning model while the control group used a conventional model.
Conclusion: There is an effectiveness of project-based seamless learning model on critical thinking skills of prospective early childhood education educator students. Hopefully, the project-based seamless learning model can be applied at various levels of educational institutions, various subject matter so that the quality of learning will be better. Can improve and develop various skills of students during learning.
Development and validation of a comprehensive patient‐specific quality assurance program for a novel stereotactic radiation delivery system for breast lesions
Authors: Becker Stewart J. , Niu Ying , Mutaf Yildirim , Chen Shifeng , Poirier Yannick , Nichols Elizabeth M. , Yi ByongYong 
Published: December 2019

AbstractPurposeThe GammaPod is a dedicated prone breast stereotactic radiosurgery (SRS) machine composed of 25 cobalt‐60 sources which rotate around the breast to create highly conformal dose distributions for boosts, partial‐breast irradiation, or neo‐adjuvant SRS. We describe the development and validation of a patient‐specific quality assurance (PSQA) system for the GammaPod.MethodsWe present two PSQA methods: measurement based and calculation based PSQA. The measurements are performed with a combination of absolute and relative dose measurements. Absolute dosimetry is performed in a single point using a 0.053‐cc pinpoint ionization chamber in the center of a polymethylmethacrylate (PMMA) breast phantom and a water‐filled breast cup. Relative dose distributions are verified with EBT3 film in the PMMA phantom. The calculation‐based method verifies point doses with a novel semi‐empirical independent‐calculation software.ResultsThe average (± standard deviation) breast and target sizes were 1263 ± 335.3 cc and 66.9 ± 29.9 cc, respectively. All ion chamber measurements performed in water and the PMMA phantom agreed with the treatment planning system (TPS) within 2.7%, with average (max) difference of –1.3% (−1.9%) and −1.3% (−2.7%), respectively. Relative dose distributions measured by film showed an average gamma pass rate of 97.0 ± 3.2 when using a 3%/1 mm criteria. The lowest gamma analysis pass rate was 90.0%. The independent calculation software had average agreements (max) with the patient and QA plan calculation of 0.2% (2.2%) and −0.1% (2.0%), respectively.ConclusionWe successfully implemented the first GammaPod PSQA program. These results show that the GammaPod can be used to calculate and deliver the predicted dose precisely and accurately. For routine PSQA performed prior to treatments, the independent calculation is recommended as it verifies the accuracy of the planned dose without increasing the risk of losing vacuum due to prolonged waiting times.
Searching for faces in crowd chokepoint videos
Authors: Kramer Robin S. S. , Hardy Sarah C. , Ritchie Kay L. 
Published: December 2019

SummaryInvestigations of face identification have typically focussed on matching faces to photographic IDs. Few researchers have considered the task of searching for a face in a crowd. In Experiment 1, we created the Chokepoint Search Test to simulate real‐time search for a target. Performance on this test was poor (39% accuracy) and showed moderate associations with tests of face matching and memory. In addition, trial‐level confidence predicted accuracy, and for those participants who were previously familiar with one or more targets, higher familiarity was associated with increased accuracy. In Experiment 2, we found improvements in performance on the test when three recent images of the target, but not three social media images, were displayed during searches. Taken together, our results highlight the difficulties inherent in real‐time searching for faces, with important implications for those security personnel who carry out this task on a daily basis.
Most family physicians report communicating the risks of adverse drug reactions in words (vs. numbers)
Authors: Juanchich Marie , Sirota Miroslav 
Published: December 2019

SummaryFamily physicians can communicate to patients the risk of adverse drug reactions using words or numbers, and this format has important implications for patients' ability to make informed decisions. The present study (a) assessed which formats family physicians preferred to communicate the risk of a given side effect, (b) tested whether the severity of this adverse drug reaction affected this preference, and (c) investigated the type of quantifiers physicians preferred to use in general (e.g., ratios, percentages). In a format selection task, a sample of 131 family physicians reported that they mostly use words to communicate to patients the risk of mild and severe adverse drug reactions, but the verbal preference was weaker for severe adverse drug reactions. The quantifier selection task showed that the most common quantifiers were verbal frequencies and verbal probabilities. Family physicians and patients should be aware of the implications of this preference.
In Situ Preparation of Thin and Rigid COF Film on Li Anode as Artificial Solid Electrolyte Interphase Layer Resisting Li Dendrite Puncture
Authors: Chen Dongdong , Huang Sheng , Zhong Lei , Wang Shuanjin , Xiao Min , Han Dongmei , Meng Yuezhong 
Published: December 2019

AbstractMetallic Li is considered the most promising anode material for high‐energy density batteries due to its high theoretical capacity and low electrochemical potential. However, commercialization of the Li anode has been hampered by the safety issue associated with Li‐dendrite growth resulting from uneven Li‐ion deposition and an unstable solid electrolyte interphase (SEI). Herein, an in situ prepared 10 nm thin film of covalent organic framework (COF) uniformly covered on the Li anode (COF‐Li) is used as an artificial SEI layer for Li plating/striping stabilization and Li dendrite inhibition. Abundant microcellular structures in the COF can redistribute the Li‐ion flux and lead to the homogeneous plating/stripping process. Meanwhile, the superhard mechanical properties and mechanical behavior during needling of the ultrathin COF film is studied via the digital pulsed force mode equipped in atomic force microscopy, illustrating a high Young's modulus of 6.8 GPa that is strong enough to resist dendrite growth. As a result, stable cycling for 400 h is achieved in the COF‐Li symmetrical cell at a current density of 1 mA cm−2, and the internal short circuit is effectively blocked by COF‐Li in Li–S batteries.
Immunology‐Guided Biomaterial Design for Mucosal Cancer Vaccines
Authors: Ferber Shiran , Gonzalez Rodrigo J. , Cryer Alexander M. , von Andrian Ulrich H. , Artzi Natalie 
Published: December 2019

AbstractCancer of mucosal tissues is a major cause of worldwide mortality for which only palliative treatments are available for patients with late‐stage disease. Engineered cancer vaccines offer a promising approach for inducing antitumor immunity. The route of vaccination plays a major role in dictating the migratory pattern of lymphocytes, and thus vaccine efficacy in mucosal tissues. Parenteral immunization, specifically subcutaneous and intramuscular, is the most common vaccination route. However, this induces marginal mucosal protection in the absence of tissue‐specific imprinting signals. To circumvent this, the mucosal route can be utilized, however degradative mucosal barriers must be overcome. Hence, vaccine administration route and selection of materials able to surmount transport barriers are important considerations in mucosal cancer vaccine design. Here, an overview of mucosal immunity in the context of cancer and mucosal cancer clinical trials is provided. Key considerations are described regarding the design of biomaterial‐based vaccines that will afford antitumor immune protection at mucosal surfaces, despite limited knowledge surrounding mucosal vaccination, particularly aided by biomaterials and mechanistic immune–material interactions. Finally, an outlook is given of how future biomaterial‐based mucosal cancer vaccines will be shaped by new discoveries in mucosal vaccinology, tumor immunology, immuno‐therapeutic screens, and material–immune system interplay.
Graphene Quantum Dots and Their Applications in Bioimaging, Biosensing, and Therapy
Authors: Chung Seokhwan , Revia Richard A. , Zhang Miqin 
Published: December 2019

AbstractGraphene quantum dots (GQDs) are carbon‐based, nanoscale particles that exhibit excellent chemical, physical, and biological properties that allow them to excel in a wide range of applications in nanomedicine. The unique electronic structure of GQDs confers functional attributes onto these nanomaterials such as strong and tunable photoluminescence for use in fluorescence bioimaging and biosensing, a high loading capacity of aromatic compounds for small‐molecule drug delivery, and the ability to absorb incident radiation for use in the cancer‐killing techniques of photothermal and photodynamic therapy. Recent advances in the development of GQDs as novel, multifunctional biomaterials are presented with a focus on their physicochemical, electronic, magnetic, and biological properties, along with a discussion of technical progress in the synthesis of GQDs. Progress toward the application of GQDs in bioimaging, biosensing, and therapy is reviewed, along with a discussion of the current limitations and future directions of this exciting material.
Chiral Surface and Geometry of Metal Nanocrystals
Authors: Im Sang Won , Ahn Hyo‐Yong , Kim Ryeong Myeong , Cho Nam Heon , Kim Hyeohn , Lim Yae‐Chan , Lee Hye‐Eun , Nam Ki Tae 
Published: December 2019

AbstractChirality is a basic property of nature and has great importance in photonics, biochemistry, medicine, and catalysis. This importance has led to the emergence of the chiral inorganic nanostructure field in the last two decades, providing opportunities to control the chirality of light and biochemical reactions. While the facile production of 3D nanostructures has remained a major challenge, recent advances in nanocrystal synthesis have provided a new pathway for efficient control of chirality at the nanoscale by transferring molecular chirality to the geometry of nanocrystals. Interestingly, this discovery stems from a purely crystallographic outcome: chirality can be generated on high‐Miller‐index surfaces, even for highly symmetric metal crystals. This is the starting point herein, with an overview of the scientific history and a summary of the crystallographic definition. With the advance of nanomaterial synthesis technology, high‐Miller‐index planes can be selectively exposed on metallic nanoparticles. The enantioselective interaction of chiral molecules and high‐Miller‐index facets can break the mirror symmetry of the metal nanocrystals. Herein, the fundamental principle of chirality evolution is emphasized and it is shown how chiral surfaces can be directly correlated with chiral morphologies, thus serving as a guide for researchers in chiral catalysts, chiral plasmonics, chiral metamaterials, and photonic devices.
In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing
Authors: Zeng Yuze , Shih Yu‐Ru V. , Baht Gurpreet S. , Varghese Shyni 
Published: December 2019

AbstractApproaches that enable innate repair mechanisms hold great potential for tissue repair. Herein, biomaterial‐assisted sequestration of small molecules is described to localize pro‐regenerative signaling at the injury site. Specifically, a synthetic biomaterial containing boronate molecules is designed to sequester adenosine, a small molecule ubiquitously present in the human body. The biomaterial‐assisted sequestration of adenosine leverages the transient surge of extracellular adenosine following injury to prolong local adenosine signaling. It is demonstrated that implantation of the biomaterial patch following injury establishes an in situ stockpile of adenosine, resulting in accelerated healing by promoting both osteoblastogenesis and angiogenesis. The adenosine content within the patch recedes to the physiological level as the tissue regenerates. In addition to sequestering endogenous adenosine, the biomaterial is also able to deliver exogenous adenosine to the site of injury, offering a versatile solution to utilizing adenosine as a potential therapeutic for tissue repair.
From Molecular Machines to Stimuli‐Responsive Materials
Authors: Moulin Emilie , Faour Lara , Carmona‐Vargas Christian C. , Giuseppone Nicolas 
Published: December 2019

AbstractArtificial molecular machines are able to produce and exploit precise nanoscale actuations in response to chemical or physical triggers. Recent scientific efforts have been devoted to the integration, orientation, and interfacing of large assemblies of molecular machines in order to harness their collective actuations at larger length scale and up to the generation of macroscopic motions. Making use of such “hierarchical mechanics” represents a fundamentally new approach for the conception of stimuli‐responsive materials. Furthermore, because some molecular machines can function as molecular motors—which are capable of cycling a unidirectional motion out of thermodynamic equilibrium and progressively increasing the work delivered to their environment—one can expect unique opportunities to design new kinds of mechanically active materials and devices capable of autonomous behavior when supplied by an external source of energy. Recently reported achievements are summarized, including the integration of molecular machines at surfaces and interfaces, in 3D self‐assembled materials, as well as in liquid crystals and polymer materials. Their detailed functioning principles as well as their functional properties are discussed along with their potential applications in various domains such as sensing, drug delivery, electronics, optics, plasmonics, and mechanics.
A Sub‐10 nm Vertical Organic/Inorganic Hybrid Transistor for Pain‐Perceptual and Sensitization‐Regulated Nociceptor Emulation
Authors: Feng Guangdi , Jiang Jie , Zhao Yuhang , Wang Shitan , Liu Biao , Yin Kai , Niu Dongmei , Li Xiaohui , Chen Yiqin , Duan Huigao , Yang Junliang , He Jun , Gao Yongli , Wan Qing 
Published: December 2019

AbstractPain‐perceptual nociceptors (PPN) are essential sensory neurons that recognize harmful stimuli and can empower the human body to react appropriately and perceive precisely unusual or dangerous conditions in the real world. Furthermore, the sensitization‐regulated nociceptors (SRN) can greatly assist pain‐sensitive human to reduce pain sensation by normalizing hyperexcitable central neural activity. Therefore, the implementation of PPNs and SRNs in hardware using emerging nanoscale devices can greatly improve the efficiency of bionic medical machines by giving them different sensitivities to external stimuli according to different purposes. However, current most‐normal organic/oxide transistors face a great challenge due to channel scaling, especially in the sub‐10 nm channel technology. Here, a sub‐10 nm indium‐tin‐oxide transistor with an ultrashort vertical channel as low as ≈3 nm, using sodium alginate bio‐polymer electrolyte as gate dielectric, is demonstrated. This device can emulate important characteristics of PPN such as pain threshold, memory of prior injury, and pain sensitization/desensitization. Furthermore, the most intriguing character of SRN can be achieved by tuning the channel thickness. The proposed device can open new avenues for the fascinating applications of next‐generation neuromorphic brain‐like systems, such as bio‐inspired electronic skins and humanoid robots.
Scleral Lens Sensor for Ocular Electrolyte Analysis
Authors: Yetisen Ali K. , Jiang Nan , Castaneda Gonzalez Carmen M. , Erenoglu Zeynep Izlen , Dong Jie , Dong Xingchen , Stößer Simon , Brischwein Martin , Butt Haider , Cordeiro Maria F. , Jakobi Martin , Hayden Oliver , Koch Alexander W. 
Published: December 2019

AbstractThe quantitative analysis of tear analytes in point‐of‐care settings can enable early diagnosis of ocular diseases. Here, a fluorescent scleral lens sensor is developed to quantitatively measure physiological levels of pH, Na+, K+, Ca2+, Mg2+, and Zn2+ ions. Benzenedicarboxylic acid, a pH probe, displays a sensitivity of 0.12 pH units within pH 7.0–8.0. Crown ether derivatives exhibit selectivity to Na+ and K+ ions within detection ranges of 0–100 and 0–50 mmol L−1, and selectivities of 15.6 and 8.1 mmol L−1, respectively. A 1,2 bis(o‐aminophenoxy)ethane‐N,N,‐N',N'‐tetraacetic‐acid‐based probe allows Ca2+ ion sensing with 0.02–0.05 mmol L−1 sensitivity within 0.50–1.25 mmol L−1 detection range. 5‐Oxazolecarboxylic acid senses Mg2+ ions, exhibiting a sensitivity of 0.10–0.44 mmol L−1 within the range of 0.5–0.8 mmol L−1. The N‐(2‐methoxyphenyl)iminodiacetate Zn2+ ion sensor has a sensitivity of 1 µmol L−1 within the range of 10–20 µmol L−1. The fluorescent sensors are subsequently multiplexed in the concavities of an engraved scleral lens. A handheld ophthalmic readout device comprising light‐emitting diodes (LEDs) and bandpass filters is fabricated to excite as well as read the scleral sensor. A smartphone camera application and an user interface are developed to deliver quantitative measurements with data deconvolution. The ophthalmic system enables the assessment of dry eye severity stages and the differentiation of its subtypes.
A Versatile Polymer‐Based Platform for Intracellular Delivery of Macromolecules
Authors: Kopytynski Michal , Chen Siyuan , Legg Sandrine , Minter Ralph , Chen Rongjun 
Published: December 2019

AbstractThe plasma membrane barrier greatly restricts intracellular delivery of macromolecules. Currently available methods suffer from various limitations, including low delivery efficiency, high cytotoxicity, or incompatibility with a wider range of macromolecules or cell types. To overcome these issues, stimuli‐responsive polymers such as the bio‐inspired, pH‐responsive poly(l‐lysine isophthalamide) grafted with l‐phenylalanine at a stoichiometric ratio of 50% (PP50) can be used. In mildly acidic environments, the pseudopeptidic polymer can permeabilize the plasma membrane overcoming the problem of payload entrapment in the endosomes and allowing for efficient intracellular delivery. It is demonstrated that PP50 is capable of intracellular delivery by simple co‐incubation at pH 6.5 with various macromolecules, including different‐sized Dextrans, green fluorescent protein (GFP), and an apoptotic peptide. The delivery process is fast, nontoxic, and compatible with multiple cell types, including adherent and suspension cell lines, primary human mesenchymal stem cells, and cells grown as spheroids. In addition, apoptotic peptide delivery by co‐incubation with PP50 is over three times more effective than delivery using other common methods, including poly(ethyleneimine) (PEI), cell penetrating peptides (CPPs), and electroporation. The findings suggest that payload delivery by co‐incubation with PP50 is a flexible, controllable method allowing delivery of various payloads to many different cell types in vitro.
Vacuum‐Assisted Growth of Low‐Bandgap Thin Films (FA0.8MA0.2Sn0.5Pb0.5I3) for All‐Perovskite Tandem Solar Cells
Authors: Abdollahi Nejand Bahram , Hossain Ihteaz M. , Jakoby Marius , Moghadamzadeh Somayeh , Abzieher Tobias , Gharibzadeh Saba , Schwenzer Jonas A. , Nazari Pariya , Schackmar Fabian , Hauschild Dirk , Weinhardt Lothar , Lemmer Uli , Richards Bryce S. , Howard Ian A. , Paetzold Ulrich W. 
Published: December 2019

AbstractAll‐perovskite multijunction photovoltaics, combining a wide‐bandgap (WBG) perovskite top solar cell (EG ≈1.6–1.8 eV) with a low‐bandgap (LBG) perovskite bottom solar cell (EG < 1.3 eV), promise power conversion efficiencies (PCEs) >33%. While the research on WBG perovskite solar cells has advanced rapidly over the past decade, LBG perovskite solar cells lack PCE as well as stability. In this work, vacuum‐assisted growth control (VAGC) of solution‐processed LBG perovskite thin films based on mixed Sn–Pb perovskite compositions is reported. The reported perovskite thin films processed by VAGC exhibit large columnar crystals. Compared to the well‐established processing of LBG perovskites via antisolvent deposition, the VAGC approach results in a significantly enhanced charge‐carrier lifetime. The improved optoelectronic characteristics enable high‐performance LBG perovskite solar cells (1.27 eV) with PCEs up to 18.2% as well as very efficient four‐terminal all‐perovskite tandem solar cells with PCEs up to 23%. Moreover, VAGC leads to promising reproducibility and potential in the fabrication of larger active‐area solar cells up to 1 cm2.