bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are men who have sex with men in Europe protected from hepatitis B?
Authors: Brandl M. , Schmidt A. J. , Marcus U. , an der Heiden M. , Dudareva S. 
Published: February 2020

Abstract
Hepatitis B vaccination is recommended for men who have sex with men (MSM) in many countries, but information on vaccine coverage is scarce. We studied hepatitis B vaccination programmes and coverage among MSM in Europe to guide prevention. From a large (N = 174 209) pan-European MSM survey (EMIS-2010), we used data on self-reported hepatitis B vaccination, age, education, settlement size and disclosure of the same-sex sexual orientation (‘outness’). We excluded participants with a history of hepatitis B. In multilevel (participants, countries) logistic regression models, we calculated adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). We analysed data of 163 987 MSM in 38 European countries: 38.3% were ‘out’ to all or almost all, 56.4% reported vaccination against hepatitis B and 65.5% lived in countries with free recommended hepatitis B vaccination for MSM. In the final model the odds for being vaccinated increased with outness (‘out to all or almost all’: aOR 1.76, 95% CI 1.70–1.83 vs. ‘out to no one’) and with living in countries, where hepatitis B vaccination was recommended and free-of-charge for MSM (aOR 2.21, 95% CI 1.47–3.32 vs. ‘no or unclear recommendation’). To increase hepatitis B vaccination coverage among MSM, implementation of MSM-specific recommendations and improvement of the societal climate for MSM is needed.
Turán numbers of theta graphs
Authors: Bukh Boris , Tait Michael 
Published: February 2020

AbstractThe theta graph
${\Theta _{\ell ,t}}$
consists of two vertices joined by t vertex-disjoint paths, each of length
$\ell $
. For fixed odd
$\ell $
and large t, we show that the largest graph not containing
${\Theta _{\ell ,t}}$
has at most
${c_\ell }{t^{1 - 1/\ell }}{n^{1 + 1/\ell }}$
edges and that this is tight apart from the value of
${c_\ell }$
.
The globalization of hybrid maize, 1921–70
Authors: Byerlee Derek 
Published: February 2020

AbstractWell before the green revolution in the 1960s, hybrid maize technology that had originally been developed in the USA spread across the world, starting before the Second World War. This article uses a framework that analyses the type of transfer (materials, knowledge, or capacity), the roles of diverse actors, and farmer demand and its market context, to trace the diffusion of hybrid technology to Latin America, Asia, Europe, and Africa up to 1970. The article also highlights the importance of access to diverse germplasm from the Americas provided by indigenous farmers. A handful of US public institutions promoted the spread of hybrid technology, with US private seed companies sometimes playing a secondary role. However, most cases of successful transfer were led by national scientists embedded in local institutions, who were able to link to local seed systems and farmers. By the mid 1970s, the aggregate impacts of these efforts were of the same magnitude as for the well-known and much publicized green revolution wheat varieties. Nonetheless, adoption of hybrid maize across and within countries was very patchy, relating to differences in scientific capacity, type of farmer, agro-ecology, and complementary investments in seed systems and extension. Consequently, impacts were often highly inequitable.
Islamic Neoliberalism for Jordan's Islamic Action Front in Islamic Banking and Finance
Authors: Tobin Sarah A. 
Published: February 2020

AbstractThere is a paradox: why are there so many political and economic Islamic actors in the Middle East but not a large willingness on their part to adopt and promote Islamic banking and finance methodologies? This paper argues that the more vague and ambivalent these actors are on economic policy, the wider their appeal; and, by extension, the more compatible Islamic ideas and ideologies are with neoliberalism. The case of the Islamic Action Front (IAF) in Jordan is given as it has adopted an emphasis on Islamic middle-class values and ethical concerns of neoliberalism in order to gain political support. The case of the IAF demonstrates that there are points of compatibility between the neoliberal economy and Islamist politics. In the calibrations of the relationship between the state and Islamist party politics in line with Islamic neoliberal tenets, this approach ensures enhanced appeal for neoliberal Islamism into the future.
PRE herbicides and POST halosulfuron for purple nutsedge control in tomato grown in plasticulture systems
Authors: Yu Jialin , Sharpe Shaun S. , Boyd Nathan S. 
Published: February 2020

AbstractPurple nutsedge is a troublesome weed in tomato grown in plasticulture systems. Field trials were conducted in the fall of 2017 and spring of 2018 at Balm, FL, to evaluate multiple herbicide programs applied pretransplanting (pre-T), post-transplanting (post-T), and pre-T followed by (fb) post-T for purple nutsedge control in plasticulture tomato. Pre-T treatment of sulfentrazone or S-metolachlor alone were ineffective and did not decrease purple nutsedge density compared with the nontreated control. Post-T application of halosulfuron did not reduce purple nutsedge density at 12 wk after initial treatment (WAIT) in fall 2017 but reduced the purple nutsedge density at 17 WAIT in both seasons. Pre-T sulfentrazone or S-metolachlor application fb halosulfuron applied post-T were the most effective treatments and consistently reduced purple nutsedge population in both seasons. Herbicide treatments did not injure or reduce tomato height or yield. Overall, these results suggest sequential herbicide programs, including pre-T application of sulfentrazone or S-metolachlor fb post-T application of halosulfuron generally resulted in greater purple nutsedge control compared with pre-T or post-T application only. Halosulfuron applied post-T is critical to provide season-long purple nutsedge control in plasticulture tomato.
Spatiotemporal Relationships between Two Closely‐spaced Strombolian‐style Vents, Yasur, Vanuatu
Authors: Simons B.C. , Jolly A.D. , Eccles J.D. , Cronin S.J. 
Published: February 2020

AbstractThis study details a case of transition of volcanic activity between two closely spaced (20–40 m) vents within the southern crater of Yasur Volcano, Vanuatu, over a period of 12 days. The transition from one vent to another newly emerged one was captured by a multi‐instrument array, with broadband seismic, thermal‐IR camera, and visual recordings presented. The results describe systematic changes in explosive parameters (e.g., style, power, and frequency) at both vents that reflect the transfer of magma and volatile gas flux within a shallow branching conduit system. The decline of activity at the initial vent corresponds with a shift from bomb‐rich to ash‐rich behavior indicating a progressive decrease in magma and volatile gas flux and increasing shallow conduit magma viscosity. The concurrent increase in activity at the emerging vent accompanies more bomb‐rich behavior that indicates increased flux and lower magma viscosity. During the transition period, most explosions were systematically paired between the two vents, occurring within <1 to up to 45 s of each other. Broadband seismic data show that paired explosions produce a common seismic signal that resembles that of a single, nonpaired explosion. The presence of a common low‐frequency (0.06–1 Hz) signal indicates that multiple shallow conduits may transmit the same gas and impulsive energy differently from a single gas rise and burst event. Temporal offsets between paired explosions reflect the different conduit pathways and viscosity states of the magma in each conduit, with the lagging vent always displaying greater ash‐rich activity indicating higher magma viscosity and gas path tortuosity.
Causal Effect of Impervious Cover on Annual Flood Magnitude for the United States
Authors: Blum Annalise G. , Ferraro Paul J. , Archfield Stacey A. , Ryberg Karen R. 
Published: February 2020

AbstractDespite consensus that impervious surfaces increase flooding, the magnitude of the increase remains uncertain. This uncertainty largely stems from the challenge of isolating the effect of changes in impervious cover separate from other factors that also affect flooding. To control for these factors, prior study designs rely on either temporal or spatial variation in impervious cover. We leverage both temporal and spatial variation in a panel data regression design to isolate the effect of impervious cover on floods. With 39 years of data from 280 U.S. streamgages, we estimate that a one percentage point increase in impervious basin cover causes a 3.3% increase in annual flood magnitude (95%CI: 1.9%, 4.7%) on average. Using 2,109 streamgages, some of which have upstream regulation and/or overlapping basins, we estimate a larger effect: 4.6% (CI: 3.5%, 5.6%). The approach introduced here can be extended to estimate the causal effects of other drivers of hydrologic change.
Modeling the Impact of Metallic Ion Layers on Equatorial Spread With SAMI3/ESF
Authors: Huba J. D. , Krall J. , Drob D. 
Published: February 2020

AbstractThe impact of
region metal ion layers on the development of equatorial plasma bubbles is investigated using the SAMI3/ESF model. We find that metal ion layers reduce the growth rate of the generalized Rayleigh‐Taylor instability (GRTI) and act to suppress the development of equatorial plasma bubbles. This is consistent with theoretical expectations and observations and is attributed to the increase in both the Pedersen and Hall conductances. Additionally, inhomogeneities in the
region metal ion layer can map into the
layer and alter the morphology of equatorial spread
(ESF) bubble evolution. Lastly, we find that if EFS bubbles develop in the presence of a metal ion layer, then the electric fields generated by the instability can lift the metal ions into the
region. This is consistent with observations of Fe
in the
region during equatorial spread
.
NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis
Authors: Luiken Sarah , Fraas Angelika , Bieg Matthias , Sugiyanto Raisatun , Goeppert Benjamin , Singer Stephan , Ploeger Carolin , Warsow Gregor , Marquardt Jens U. , Sticht Carsten , De La Torre Carolina , Pusch Stefan , Mehrabi Arianeb , Gretz Norbert , Schlesner Matthias , Eils Roland , Schirmacher Peter , Longerich Thomas , Roessler Stephanie 
Published: February 2020

AbstractNOTCH receptor signaling plays a pivotal role in liver homeostasis and hepatocarcinogenesis. However, the role of NOTCH pathway mutations and the NOTCH target gene HES5 in liver tumorigenesis are poorly understood. Here we performed whole-exome sequencing of 54 human HCC specimens and compared the prevalence of NOTCH pathway component mutations with the TCGA-LIHC cohort (N = 364). In addition, we functionally characterized the NOTCH target HES5 and the patient-derived HES5-R31G mutation in vitro and in an orthotopic mouse model applying different oncogenic backgrounds, to dissect the role of HES5 in different tumor subgroups in vivo. We identified nonsynonymous mutations in 14 immediate NOTCH pathway genes affecting 24.1% and 16.8% of HCC patients in the two independent cohorts, respectively. Among these, the HES5-R31G mutation was predicted in silico to have high biological relevance. Functional analyses in cell culture showed that HES5 reduced cell migration and clonogenicity. Further analyses revealed that the patient-derived HES5-R31G mutant protein was non-functional due to loss of DNA binding and greatly reduced nuclear localization. Furthermore, HES5 exhibited a negative feedback loop by directly inhibiting the NOTCH target HES1 and downregulated the pro-proliferative MYC targets ODC1 and LDHA. Interestingly, HES5 inhibited MYC-dependent hepatocarcinogenesis, whereas it promoted AKT-dependent liver tumor formation and stem cell features in a murine model. Thus, NOTCH pathway component mutations are commonly observed in HCC. Furthermore, the NOTCH target gene HES5 has both pro- and anti-tumorigenic functions in liver cancer proposing a driver gene dependency and it promotes tumorigenesis with its interaction partner AKT.
MFAP2 is overexpressed in gastric cancer and promotes motility via the MFAP2/integrin α5β1/FAK/ERK pathway
Authors: Yao Li-wen , Wu Lian-lian , Zhang Li-hui , Zhou Wei , Wu Lu , He Ke , Ren Jia-cai , Deng Yun-chao , Yang Dong-mei , Wang Jing , Mu Gang-gang , Xu Ming , Zhou Jie , Xiang Guo-an , Ding Qian-shan , Yang Yan-ning , Yu Hong-gang 
Published: February 2020

AbstractGastric cancer (GC) is one of the most common malignancies and its prognosis is extremely poor. This study identifies a novel oncogene, microfibrillar-associated protein 2 (MFAP2) in GC. With integrative reanalysis of transcriptomic data, we found MFAP2 as a GC prognosis-related gene. And the aberrant expression of MFAP2 was explored in GC samples. Subsequent experiments indicated that silencing and exogenous MFAP2 could affect motility of cancer cells. The inhibition of silencing MFAP2 could be rescued by another FAK activator, fibronectin. This process is probably through affecting the activation of focal adhesion process via modulating ITGB1 and ITGA5. MFAP2 regulated integrin expression through ERK1/2 activation. Silencing MFAP2 by shRNA inhibited tumorigenicity and metastasis in nude mice. We also revealed that MFAP2 is a novel target of microRNA-29, and miR-29/MFAP2/integrin α5β1/FAK/ERK1/2 could be an important oncogenic pathway in GC progression. In conclusion, our data identified MFAP2 as a novel oncogene in GC and revealed that miR-29/MFAP2/integrin α5β1/FAK/ERK1/2 could be an important oncogenic pathway in GC progression.
CUL4B contributes to cancer stemness by repressing tumor suppressor miR34a in colorectal cancer
Authors: Li Yanjun , Hu Huili , Wang Yuxing , Fan Yujia , Yang Yang , Guo Beibei , Xie Xueyong , Lian Jiabei , Jiang Baichun , Han Bo , Wang Yanlei , Shao Changshun , Gong Yaoqin 
Published: February 2020

AbstractGiven that colorectal cancer stem cells (CCSCs) play key roles in the tumor dormancy, metastasis, and relapse, targeting CCSCs is a promising strategy in cancer therapy. Here, we aimed to identify the new regulators of CCSCs and found that Cullin 4B (CUL4B), which possesses oncogenic properties in multiple solid tumors, drives the development and metastasis of colon cancer by sustaining cancer stem-like features. Elevated expression of CUL4B was confirmed in colon tumors and was associated with poor overall survival. Inhibition of CUL4B in cancer cell lines and patient-derived tumor organoids led to reduced sphere formation, proliferation and metastasis capacity. Mechanistically, CUL4B coordinates with PRC2 complex to repress miR34a expression, thus upregulates oncogenes including MYCN and NOTCH1, which are targeted by miR34a. Furthermore, we found that elevated CUL4B expression is associated with miR34a downregulation and upregulation of miR34a target genes in colon cancer specimens. Collectively, our findings demonstrate that CUL4B functions to repress miR34a in maintaining cancer stemness in CRC and provides a potential therapeutic target.
Natural images are reliably represented by sparse and variable populations of neurons in visual cortex
Authors: Yoshida Takashi , Ohki Kenichi 
Published: February 2020

AbstractNatural scenes sparsely activate neurons in the primary visual cortex (V1). However, how sparsely active neurons reliably represent complex natural images and how the information is optimally decoded from these representations have not been revealed. Using two-photon calcium imaging, we recorded visual responses to natural images from several hundred V1 neurons and reconstructed the images from neural activity in anesthetized and awake mice. A single natural image is linearly decodable from a surprisingly small number of highly responsive neurons, and the remaining neurons even degrade the decoding. Furthermore, these neurons reliably represent the image across trials, regardless of trial-to-trial response variability. Based on our results, diverse, partially overlapping receptive fields ensure sparse and reliable representation. We suggest that information is reliably represented while the corresponding neuronal patterns change across trials and collecting only the activity of highly responsive neurons is an optimal decoding strategy for the downstream neurons.
Improved osmotic energy conversion in heterogeneous membrane boosted by three-dimensional hydrogel interface
Authors: Zhang Zhen , He Li , Zhu Congcong , Qian Yongchao , Wen Liping , Jiang Lei 
Published: February 2020

AbstractThe emerging heterogeneous membranes show unprecedented superiority in harvesting the osmotic energy between ionic solutions of different salinity. However, the power densities are limited by the low interfacial transport efficiency caused by a mismatch of pore alignment and insufficient coupling between channels of different dimensions. Here we demonstrate the use of three-dimensional (3D) gel interface to achieve high-performance osmotic energy conversion through hybridizing polyelectrolyte hydrogel and aramid nanofiber membrane. The ionic diode effect of the heterogeneous membrane facilitates one-way ion diffusion, and the gel layer provides a charged 3D transport network, greatly enhancing the interfacial transport efficiency. When used for harvesting the osmotic energy from the mixing of sea and river water, the heterogeneous membrane outperforms the state-of-the-art membranes, to the best of our knowledge, with power densities of 5.06 W m−2. The diversity of the polyelectrolyte and gel makes our strategy a potentially universal approach for osmotic energy conversion.
Evapotranspiration depletes groundwater under warming over the contiguous United States
Authors: Condon Laura E. , Atchley Adam L. , Maxwell Reed M. 
Published: February 2020

AbstractA warmer climate increases evaporative demand. However, response to warming depends on water availability. Existing earth system models represent soil moisture but simplify groundwater connections, a primary control on soil moisture. Here we apply an integrated surface-groundwater hydrologic model to evaluate the sensitivity of shallow groundwater to warming across the majority of the US. We show that as warming shifts the balance between water supply and demand, shallow groundwater storage can buffer plant water stress; but only where shallow groundwater connections are present, and not indefinitely. As warming persists, storage can be depleted and connections lost. Similarly, in the arid western US warming does not result in significant groundwater changes because this area is already largely water limited. The direct response of shallow groundwater storage to warming demonstrates the strong and early effect that low to moderate warming may have on groundwater storage and evapotranspiration.
Planar Hall effect and anisotropic magnetoresistance in polar-polar interface of LaVO3-KTaO3 with strong spin-orbit coupling
Authors: Wadehra Neha , Tomar Ruchi , Varma Rahul Mahavir , Gopal R. K. , Singh Yogesh , Dattagupta Sushanta , Chakraverty S. 
Published: February 2020

AbstractAmong the perovskite oxide family, KTaO3 (KTO) has recently attracted considerable interest as a possible system for the realization of the Rashba effect. In this work, we report a novel conducting interface by placing KTO with another insulator, LaVO3 (LVO) and report planar Hall effect (PHE) and anisotropic magnetoresistance (AMR) measurements. This interface exhibits a signature of strong spin-orbit coupling. Our experimental observations of two fold AMR and PHE at low magnetic fields (B) is similar to those obtained for topological systems and can be intuitively understood using a phenomenological theory for a Rashba spin-split system. Our experimental data show a B2 dependence of AMR and PHE at low magnetic fields that could also be explained based on our model. At high fields (~8 T), we see a two fold to four fold transition in the AMR that could not be explained using only Rashba spin-split energy spectra.
Hierarchically-structured metalloprotein composite coatings biofabricated from co-existing condensed liquid phases
Authors: Jehle Franziska , Macías-Sánchez Elena , Sviben Sanja , Fratzl Peter , Bertinetti Luca , Harrington Matthew J. 
Published: February 2020

AbstractComplex hierarchical structure governs emergent properties in biopolymeric materials; yet, the material processing involved remains poorly understood. Here, we investigated the multi-scale structure and composition of the mussel byssus cuticle before, during and after formation to gain insight into the processing of this hard, yet extensible metal cross-linked protein composite. Our findings reveal that the granular substructure crucial to the cuticle’s function as a wear-resistant coating of an extensible polymer fiber is pre-organized in condensed liquid phase secretory vesicles. These are phase-separated into DOPA-rich proto-granules enveloped in a sulfur-rich proto-matrix which fuses during secretion, forming the sub-structure of the cuticle. Metal ions are added subsequently in a site-specific way, with iron contained in the sulfur-rich matrix and vanadium coordinated by DOPA-catechol in the granule. We posit that this hierarchical structure self-organizes via phase separation of specific amphiphilic proteins within secretory vesicles, resulting in a meso-scale structuring that governs cuticle function.
Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site
Authors: Pennington Joseph M. , Kemp Michael , McGarry Lauren , Chen Yu , Stroupe M. Elizabeth 
Published: February 2020

AbstractSiroheme is the central cofactor in a conserved class of sulfite and nitrite reductases that catalyze the six-electron reduction of sulfite to sulfide and nitrite to ammonia. In Salmonella enterica serovar Typhimurium, siroheme is produced by a trifunctional enzyme, siroheme synthase (CysG). A bifunctional active site that is distinct from its methyltransferase activity catalyzes the final two steps, NAD+-dependent dehydrogenation and iron chelation. How this active site performs such different chemistries is unknown. Here, we report the structures of CysG bound to precorrin-2, the initial substrate; sirohydrochlorin, the dehydrogenation product/chelation substrate; and a cobalt-sirohydrochlorin product. We identified binding poses for all three tetrapyrroles and tested the roles of specific amino acids in both activities to give insights into how a bifunctional active site catalyzes two different chemistries and acts as an iron-specific chelatase in the final step of siroheme synthesis.