bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative bevacizumab does not increase complications following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: King Bradley H. , Baumgartner Joel M. , Kelly Kaitlyn J. , Marmor Rebecca A. , Lowy Andrew M. , Veerapong Jula 
Published: December 2020

Background
Preoperative bevacizumab has been reported to increase postoperative complication risk following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We sought to review our experience with preoperative bevacizumab in patients undergoing CRS/HIPEC for peritoneal surface malignancy.

Methods
This is a retrospective review of patients who received neoadjuvant systemic therapy with or without bevacizumab prior to CRS/HIPEC at a high-volume academic center from 2007–2018.

Results
Of 499 patients, a total of 88 patients received neoadjuvant chemotherapy alone (n = 34) or in combination with bevacizumab (n = 54) within 3 months prior to CRS/HIPEC. No differences existed in 60-day major morbidity (17.6 vs. 16.7%, p = 0.81) or 60-day mortality (0 vs. 0%) between the two cohorts, and neoadjuvant bevacizumab was not associated with increased odds of overall complications (OR 0.86, 95% CI 0.35–2.09, p = 0.73) or major morbidity (OR 0.86, 95% CI 0.24–3.00, p = 0.81). Stratifying patients by primary tumor origin and post-operative complications did not reveal any significant differences between the two treatment groups. In addition, progression-free survival (PFS) and overall survival (OS) were similar in both cohorts.

Conclusions
Preoperative bevacizumab is not associated with increased morbidity or mortality following CRS/HIPEC. Neoadjuvant therapy employing this biologic agent is safe and should not be a deterrent for aggressive cytoreduction with curative intent.
Characteristics associated with COVID-19 or other respiratory viruses’ infections at a single-center emergency department
Authors: Bouzid Donia , Mullaert Jimmy , Le Hingrat Quentin , Laurent Odile , Duval Xavier , Lescure Xavier , Timsit Jean-François , Descamps Diane , Montravers Philippe , Choquet Christophe , Lucet Jean-Christophe , Casalino Enrique , Visseaux Benoit ,   ED influenza study group
Published: December 2020

Background
Rapid identification of patients with high suspicion of COVID-19 will become a challenge with the co-circulation of multiple respiratory viruses (RVs). We have identified clinical or biological characteristics to help distinguish SARS-CoV-2 from other RVs.

Methods
We used a prospective cohort including all consecutive patients admitted through the emergency department’s (ED) and presenting respiratory symptoms from November 2019 to April 2020. Patients were tested for RV using multiplex polymerase chain reaction (mPCR) and SARS-CoV-2 RT-PCR.

Results
203/508 patients were positive for an RV during the non-SARS-CoV-2 epidemic period (November to February), and 268/596 patients were SARS-CoV-2 positive during the SARS-CoV-2 epidemic (March to April). Younger age, male gender, fever, absence of expectoration and absence of chronic lung disease were statistically associated with SARS-CoV-2 detection. Combining these variables allowed for the distinguishing of SARS-CoV-2 infections with 83, 65, 75 and 76% sensitivity, specificity, PPV and NPV, respectively.

Conclusion
Patients’ characteristics associated with a positive PCR are common between SARS-CoV-2 and other RVs, but a simple discrimination of strong SARS-CoV-2 suspicion with a limited set of clinical features seems possible. Such scoring could be useful but has to be prospectively evaluated and will not eliminate the need for rapid PCR assays.
Changes to the sample design and weighting methods of a public health surveillance system to also include persons not receiving HIV medical care
Authors: Johnson Christopher H. , Beer Linda , Harding R. Lee , Iachan Ronaldo , Moyse Davia , Lee Adam , Kyle Tonja , Chowdhury Pranesh P. , Shouse R. Luke 
Published: December 2020

Objectives
The Medical Monitoring Project (MMP) is a public health surveillance system that provides representative estimates of the experiences and behaviors of adults with diagnosed HIV in the United States. In 2015, the sample design and frame of MMP changed from a system that only included HIV patients to one that captures the experiences of persons receiving and not receiving HIV care. We describe methods investigated for calculating survey weights, the approach chosen, and the benefits of using a dynamic surveillance registry as a sampling frame.

Methods
MMP samples adults with diagnosed HIV from the National HIV Surveillance System, the HIV case surveillance registry for the United States. In the methodological study presented in this manuscript, we compared methods that account for sample design and nonresponse, including weighting class adjustment vs. propensity weighting and a single-stage nonresponse adjustment vs. sequential adjustments for noncontact and nonresponse. We investigated how best to adjust for non-coverage using surveillance data to post-stratify estimates.

Results
After assessing these methods, we chose as our preferred procedure weighting class adjustments and a single-stage nonresponse adjustment. Classes were constructed using variables associated with respondents’ characteristics and important survey outcomes, chief among them laboratory results available from surveillance that served as a proxy for medical care.

Conclusions
MMPs weighting procedures reduced sample bias by leveraging auxiliary information on medical care available from the surveillance registry sampling frame. Expanding MMPs population of focus provides important information on characteristics of persons with diagnosed HIV that complement the information provided by the surveillance registry. MMP methods can be applied to other disease registries or population-monitoring systems when more detailed information is needed for a population, with the detailed information obtained efficiently from a representative sample of the population covered by the registry.
Innovative Approaches to the Management of Commercial and Economic Activities of Environmental Enterprise - “Spicy Pack”
Authors: ARANCHIY Valentyna , YASNOLOB Ilona , DEMIANENKO Nataliia , BEZKROVNYI Oleksandr , MYKHAILOVA Olena , PYSARENKO Svitlana , CHIP Liudmyla , ARESTOV Oleksandr , HORBATIUK Liudmyla 
Published: December 2020

The comparison of eco-friendliness of paper packaging materials from wood and alternative raw materials (straw, fallen leaves, etc.) with polyethylene packaging was made. The analysis was conducted according to the following criteria: consumption of raw materials, electricity, rubbish formation, and price of selling products. Advantages and drawbacks of each raw material type were characterized. It has been mentioned that polymers make a considerable and increasing part in manufacturing packaging materials. The prospects of producing paper bags from leaves and their sales prices were analyzed. The terms of degradation of packages made from different materials were analyzed. The conclusion has been made that paper from fallen leaves is not cheap, but it is important considering its environmental safety.
SWOT analysis of “Spicy pack” enterprise’s activity was analyzed (it will be engaged in manufacturing spicy packages for food products from innovative raw materials). The expediency of making spicy packages for food products was substantiated. In particular, ‘Spicy pack” logo consisting of only eco-paper (made from fallen leaves) and spices was suggested. Such packaging will help prolong 4 times food products’ suitability.
Such spices as cloves, rosemary, oregano, curcuma, and sage having antiseptic properties will be added to packages and napkins. These products will be reused for two-three weeks, then spices vanish, and the paper can be processed.
Cechy duszpasterzy jako przywódców
Authors: Lipiec Dariusz 
Published: December 2020

Celem artykułu jest wskazanie cech duszpasterskich prezbitera, które są potrzebne do skutecznej realizacji duszpasterstwa. Na początku autor omawia charakterystykę lidera w świetle teorii zarządzania. Następnie przedstawia znaczenie cech przywódcy w posłudze prezbitera. W dalszej części wskazuje na te cechy duszpasterskie prezbitera, które są potrzebne do stworzenia zespołu duszpasterskiego i zarządzania nim. W ostatniej części prezentuje cechy prezbitera niezbędne do budowania relacji między duszpasterzem a poszczególnymi członkami zespołu duszpasterskiego. W konkluzji wskazuje, że pomimo tego, że każdy odnoszący sukcesy lider zespołu duszpasterskiego powinien posiadać liczne cechy przywódcze, trudno jest stworzyć pełną listę obejmującą wszystkie.
Mechanical Energy Expenditure at Lumbar Spine and Lower Extremity Joints During the Single-Leg Squat Is Affected by the Nonstance Foot Position
Authors: Hirsch Steven M. , Chapman Christopher J. , Frost David M. , Beach Tyson A.C. 
Published: December 2020

Abstract
Hirsch, SM, Chapman, CJ, Frost, DM, and Beach, TAC. Mechanical energy expenditure at lumbar spine and lower extremity joints during the single-leg squat is affected by the nonstance foot position. J Strength Cond Res 36(9): 2417–2426, 2022—Previous research has shown that discrete kinematic and kinetic quantities during bodyweight single-leg squat (SLS) movements are affected by elevated foot positioning and sex of the performer, but generalizations are limited by the high-dimensional data structure reported. Using a 3D inverse dynamical linked-segment model, we quantified mechanical energy expenditure (MEE) at each joint in the kinetic chain, the total MEE (sum of MEE across aforesaid joints), and the relative contribution of each joint to total MEE during SLSs performed with elevated foot positioned beside stance leg (SLS-Side), and in-front of (SLS-Front) and behind (SLS-Back) the body. Total MEE differed between SLS variations (p = 0.002), with the least amount observed in the SLS-Back (effect size [ES] = 0.066–0.069). Approximately 50% of total MEE was contributed by the knee joint in each SLS variation, whereas MEE at the ankle, hip, and lumbar spine (in absolute and relative terms) varied complexly as a function of the elevated foot position. Total MEE (p = 0.0192, ES = 0.852) and the absolute MEE at the knee and spine was greater in men across the SLS variations performed (p = 0.025–0.036, ES = 0.715–0.766), but only the lumbar spine contribution to total MEE was larger in men across all SLS variations (p = 0.045, ES = 0.607). Otherwise, there were no other sex-specific responses observed. Biomechanically, SLS movements are generally “knee-dominant,” but changing elevated foot position effectively redistributes MEE among other joints in the linkage. Consistent with the previous conclusions reached based on discrete kinematic and kinetic data, not all SLSs are equal.
Lower-Limb Biomechanics Differ Between Sexes During Maximal Loaded Countermovement Jumps
Authors: Fain AuraLea C. , Seymore Kayla D. , Lobb Nicholas J. , Brown Tyler N. 
Published: December 2020

Abstract
Fain, AC, Semore, KD, Lobb, NJ, and Brown, TN. Lower-limb biomechanics differ between sexes during maximal loaded countermovement jumps. J Strength Cond Res 35(2): 325–331, 2021—To improve military personnel's operational performance, this study determined the impact of heavy, military body–borne load on vertical jump performance. Twenty men and 17 women had lower-limb work and power quantified during a series of countermovement jumps with 4 body-borne loads (20, 25, 30, and 35 kg). For each jump, subjects stood in athletic position with feet shoulder-width apart, then squatted down and immediately performed a maximal-effort vertical jump. Subjects performed 3 successful jumps with each load. During each jump, limb and hip, knee and ankle work and power, each joint's contribution to limb work, as well as jump height and center of mass velocity were quantified. Each dependent measure was submitted to a 2-way repeated-meausres analysis of variance, with alpha level 0.05. Body-borne load reduced jump height (p = 0.001) but increased ankle work (p < 0.001). To jump higher (p < 0.001) with a greater center of mass velocity (p = 0.001), men produced more limb work (p < 0.001), hip (p = 0.001; p < 0.001), knee (p < 0.001; p < 0.001), and ankle (p < 0.001; p < 0.001) joint power and work. But, women produced a greater percentage of work at the ankle (p = 0.020) than men. Military practitioners may target different training adaptations to improve male and female personnel operational performance because lower-limb biomechanics differ between sexes during loaded vertical jumps.
Inactivating PTH/PTHrP signaling disorders (iPPSDs): evaluation of the new classification in a multicenter large series of 544 molecularly characterized patients
Authors: Pereda Arrate , Elli Francesca M , Thiele Suzanne , de Sanctis Luisa , Rothenbuhler Anya , Hanna Patrick , Francou Bruno , Ertl Diana Alexandra , Perez de Nanclares Guiomar , Linglart Agnès , Mantovani Giovanna 
Published: December 2020

Objective
Pseudohypoparathyroidism and related disorders belong to a group of heterogeneous rare diseases that share an impaired signaling downstream of Gsα-protein-coupled receptors. Affected patients may present with various combination of symptoms including resistance to PTH and/or to other hormones, ectopic ossifications, brachydactyly type E, early onset obesity, short stature and cognitive difficulties. Several years ago we proposed a novel nomenclature under the term of inactivating PTH/PTHrP signaling disorders (iPPSD). It is now of utmost importance to validate these criteria and/or improve the basis of this new classification.

Design
Retrospective study of a large international series of 459 probands and 85 relatives molecularly characterized.

Methods
Information on major and minor criteria associated with iPPSD and genetic results were retrieved from patient files. We compared the presence of each criteria according to the iPPSD subtype, age and gender of the patients.

Results
More than 98% of the probands met the proposed criteria for iPPSD classification. Noteworthy, most patients (85%) presented a combination of symptoms rather than a single sign suggestive of iPPSD and the overlap among the different genetic forms of iPPSD was confirmed. The clinical and molecular characterization of relatives identified familial history as an additional important criterion predictive of the disease.

Conclusions
The phenotypic analysis of this large cohort confirmed the utility of the major and minor criteria and their combination to diagnose iPPSD. This report shows the importance of having simple and easily recognizable signs to diagnose with confidence these rare disorders and supports a better management of patients.
The Hydration Status of Female Collegiate Soccer Players Over Consecutive Training and Match Days
Authors: Clarke Holly E. , Carpenter Rebekah S. , Spain-Mansmann Katie , Taylor James Kyle , Schubert Matthew M. 
Published: December 2020

Purpose: Hydration has been shown to play a pivotal role in sport. Soccer is a team sport in which the integrity of all players is vital for team performance; thus, individual player hydration status is important. The primary aim of this study was to investigate the hydration status of female collegiate soccer players during regular season.
Methods: Sixteen collegiate female soccer players (age: 20.4 ± 0.8 years; height: 163.6 ± 6.9 cm; weight: 65.3 ± 12 kg) provided urine over 9 days to monitor their hydration status. Hydration was determined by urine specific gravity (Usg). Usg was analyzed in the morning (AM) and in the afternoon before practice/game (PM).
Results: All 16 players were at least minimally hypohydrated (Usg > 1.010) in the AM on 5 of the 9 days tested. Players had significantly higher Usg values in the AM as compared to PM (F(1,250) = 23.09; p < 0.0001); however, there was no significant time*day interaction (F(1,250) = 1.98; p = 0.16).
Conclusion: Data show a high prevalence of hypohydration occurring in this specific population. This sub-optimal hydration status could be a cause for concern in terms of overall performance. Efforts should be made to integrate hydration interventions and daily monitoring to minimize hypohydration in players.
GARLIC-GINGER AS POTENTIAL BIO-PRESERVATIVE IN FERMENTED MAIZE AND SORGHUM PASTES
Authors: Olaniran Abiola Folakemi , Abiose Sumbo H , Adeniran Adekanmi H 
Published: December 2020

Garlic and ginger are natural spices with potentials as biopreservatives and allied health benefits. Fermented pastes either from maize or sorghum have a shelf life of fewer than 10 days except when refrigerated. In this study, garlic and ginger were added separately and in combinations to the fermented pastes prepared from maize and sorghum grains with a view to extending its shelf life resulted in 7 treatments. During storage for 4 weeks at ambient and refrigeration temperatures, the microbial load was enumerated and isolates identified using conventional methods. Physicochemical properties and shelf-life of the paste were also evaluated. Prominent in the fermented pastes during storage were 8 species of lactic acid bacteria and yeast (Saccharomyces cerevisiae and Saccharomyces rouxii). Garlic inhibited the growth of Candida utilis, Candida mycoderma, Candida tropicalis, Candida krusei, and Rhodotorula glutinis in paste during storage. Bio-preserved paste using 4% garlic with 2% ginger had the best preservative effect on total viable counts (8.29-11.30 CFU/g), lactic acid bacteria (8.3-9.70 CFU/g) and yeast (4.69-9.45 CFU/g) counts. The study established that fermented pastes produced from either maize or sorghum can be effectively bio preserved using garlic, ginger, and garlic-ginger at 2 or 4 % for 4 weeks without spoilage at ambient temperature (27± 2oC); thus, extending its shelf life.
GDP and beyond: Prosperity convergence in the countries of Western and Eastern Europe
Authors: Gligorić Matić Mirjana , Gavrilović Biljana Jovanović , Stanišić Nenad 
Published: December 2020

AbstractAfter Second World War (WWII) a true evolution in understanding of economic development happened, which affected the ways of measuring prosperity, i.e. perceiving changes in people’s welfare. Numerous indicators have been created, which go ‘beyond GDP’ and cover different aspects of development and well-being. The aim of this paper is to analyse prosperity convergence in 32 European countries with a composite indicator – Legatum Prosperity Index (LPI). LPI is more complete than other indicators used in convergence analysis and reflects multidimensional nature of modern development and prosperity. Our research of absolute beta convergence is based on cross-sectional and panel data. Results indicate the existence of convergence in the overall index and its constitutive parts – dimensions and pillars, with different convergence speed regarding LPI and its segments for the total sample of countries, as well as for the countries of Eastern and Western Europe.
Is gold a safe haven? The international evidence revisited
Authors: Bulut Levent , Rizvanoghlu Islam 
Published: December 2020

AbstractThe literature has not settled down on safe haven property of gold in the emerging and developing countries. Therefore, we revisit the international evidence on hedging and safe haven role of gold for 34 emerging and developing countries with a span of daily data covering January 2000–November 2018. We employ the GARCH-copula approach to estimate the lower-tail extreme dependencies of the joint distribution of gold and equity returns. We also introduce a new definition for the strong safe haven property of an asset. Our findings indicate that while gold serves as a hedging instrument for all countries in our sample, we got evidence of weak safe haven property for gold, for domestic investors, only in 20 countries, and a strong safe haven asset (SHA) only in 9 countries.
Hardening the budget constraint: Institutional reform in the financial management of Hungarian local governments
Authors: Vasvári Tamás 
Published: December 2020

AbstractKornai (2014) described the problems of municipal indebtedness in Hungary and analysed the process of bailout carried out between 2011 and 2014. In the same period, the central government also reformed the local government system, which included serious limitations of their financial independence. This study re-examines the state of the soft budget constraint (SBC) of Hungarian local governments. To start, the general theoretical framework of SBC is introduced. Then, the budget constraint on the Hungarian local governments before the bailout is described briefly, followed by an assessment of the corresponding measures which were expected to offset the negative messages of the completed bailout and to harden the budget constraint. The study concludes that the central government decided to harden the budget constraint through the introduction of new hierarchical mechanisms, while the development of fiscal discipline stopped. On the one hand, this resulted in the consolidation of municipal budgets, but on the other, it was accompanied by a serious limitation of local autonomy, projects and borrowing in general, while the central government employs specific administrative tools to show favour to some settlements according to its (political) interests.
Comparison of biofilm formation between non-pathogenic Listeria strains under different stress conditions
Authors: Hasani Endrit , Labidi Sabrine , Mohácsi-Farkas Csilla , Kiskó Gabriella 
Published: December 2020

AbstractMicro-organisms can attach to food surfaces and develop biofilms which present a concern in food and environmental safety. The main goal of the current study was to investigate the biofilm formation of six non-pathogenic Listeria strains under different stress conditions using a microplate assay. The effect of the weak biofilm-forming non-pathogenic Listeria strains on the biofilm formation of a strong biofilm-forming pathogenic Listeria strain (Listeria monocytogenes #8) was also examined. Listeria innocua CCM4030, Listeria innocua 2885 and Listeria seeligeri/welshimeri 292 showed the same patterns of biofilm formation with increasing NaCl concentrations from 0.05 to 15%, but all the other strains showed a continuously decreasing trend of OD595 in the same conditions. This study showed that in the case of non-pathogenic Listeria strains, higher concentrations of NaCl do not present a stress condition that enhances biofilm formation. Decrease in pH inhibited biofilm formation for all the non-pathogenic Listeria strains. The weak biofilm forming non-pathogenic Listeria strains (Listeria innocua 2885 and Listeria innocua CCM4030) overgrew the strong biofilm-forming Listeria strain (Listeria monocytogenes #8) during biofilm formation. This phenomenon could be beneficial and potentially be used as a novel control strategy to prevent the colonization of the pathogenic Listeria at food processing facilities such as in meat industry.