bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global volatility accounting and structural transformation
Authors: Harchaoui Tarek M 
Published: November 2019

AbstractThis paper examines whether the modern phase of globalization that started in the mid-1980s altered the canonical result which emphasizes that macroeconomic volatility declines with development. The application of a framework that gives due consideration to comovements and structural transformation to a near-universe sample of economies at different stages of economic development suggests the following set of results. First, with an explicit account for the roles of structural transformation and comovements, macroeconomic volatility declines during the modern phase of globalization for the Centre while it increases for the Periphery. Second, macroeconomic volatility of the Periphery declines with development only where structural transformation is ruled out—an unrealistic situation. Third, comovements are found to be quantitatively important, albeit without altering the fact that structural transformation constitutes the primary vehicle of transmissions of volatility from the Centre to the Periphery, where China emerges as the epicentre.
The Effect of Botulinum Toxin Injection into the Common Extensor Tendon in Patients with Chronic Lateral Epicondylitis: A Randomized Trial
Authors: Lee Sang Hoon , Choi Hyun Hee , Chang Min Cheol 
Published: November 2019

Abstract

Background
Botulinum toxin (BTX) is widely used for pain control in various musculoskeletal disorders.

Objectives
We evaluated the analgesic effect of botulinum toxin type A (BTX-A) in chronic lateral epicondylitis and compared the effect between 10 and 50 IU of BTX-A.

Methods
Sixty subjects with chronic lateral epicondylitis were included and underwent a BTX-A injection in the common extensor tendon. The subjects were randomly allocated into two groups: the small-dose group (SD group; 30 subjects, 10 IU) and large-dose group (LD group; 30 subjects, 50 IU). Treatment outcomes were evaluated by measuring the pain level using the numeric rating scale (NRS) and measuring grip strength before and one, two, three, four, five, and six months after treatment.

Results
Subjects in both groups showed a significant decrease in NRS scores at all evaluation time points after treatment. The reduction in NRS scores was significantly greater in the LD group at one, two, three, and four months after treatment. Six months after treatment, 19 subjects (63.3%) in the SD group and 21 (70%) in the LD group reported successful pain relief (pain relief ≥50%). The rate of successful pain relief was not significantly different between the two groups. Grip strength was more increased in the LD group at one, two, three, four, and six months after treatment.

Conclusions
BTX-A injection into the common extensor tendon can be a good treatment option for chronic lateral epicondylitis. The 50-IU BTX-A injection achieved a better outcome than the 10-IU injection.
Testing for Multiple-Horizon Predictability: Direct Regression Based versus Implication Based
Authors: Xu Ke-Li 
Published: November 2019

Abstract
Research in finance and macroeconomics has routinely employed multiple horizons to test asset return predictability. In a simple predictive regression model, we find the popular scaled test can have zero power when the predictor is not sufficiently persistent. A new test based on implication of the short-run model is suggested and is shown to be uniformly more powerful than the scaled test. The new test can accommodate multiple predictors. Compared with various other widely used tests, simulation experiments demonstrate remarkable finite-sample performance. We reexamine the predictive ability of various popular predictors for aggregate equity premium.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Active Solidarity: Intersectional Solidarity in Action
Authors: Einwohner Rachel L. , Kelly-Thompson Kaitlin , Sinclair-Chapman Valeria , Tormos-Aponte Fernando , Weldon S. Laurel , Wright Jared M. , Wu Charles 
Published: November 2019

AbstractWhile solidarity lies at the heart of collective action, it is not easily achieved. Social movements are characterized not only by difference within activist ranks but also by power asymmetries that reflect broader domination and distrust. The concept of intersectional solidarity is central to contemporary social justice movements’ efforts to negotiate these divisions, but how can it be achieved? To answer this question, we offer some guidelines for enacting intersectional solidarity, drawing on a theoretically grounded examination of three contemporary social movements in the United States and abroad (Occupy, Gezi Park, and the Women’s March).
Why Is Japan’s Housing Vacancy Rate So High? A History of Postwar Housing Policy
Authors: ZHANG Beibei 
Published: November 2019

Abstract
This article provides an explanation for Japan’s current vacant housing crisis. While existing explanations usually ascribe the crisis to demographic factors or individual governmental policies, this article seeks to transcend those explanations by situating the vacant housing phenomenon within a broader social, economic, and historical context. Drawing on historical materials, the empirical analysis deciphers how the state has subordinated housing development to the overarching objective of economic growth through the manipulation of housing finance policies and land use planning regulations during the postwar period. The article argues that today’s vacant housing crisis is the result of the state’s pro-growth housing policies throughout the postwar period.
TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma
Authors: Jiang Yan-Yi , Jiang Yuan , Li Chun-Quan , Zhang Ying , Dakle Pushkar , Kaur Harvinder , Deng Jian-Wen , Lin Ruby Yu-Tong , Han Lin , Xie Jian-Jun , Mayakonda Anand , Hazawa Masaharu , Xu Liang , Li YanYu , Aswad Luay , Jeitany Maya , Kanojia Deepika , Guan Xin-Yuan , Fullwood Melissa J. , Lin De-Chen , Koeffler H. Phillip 
Published: November 2019

SUMMARYTranscriptional network is controlled by master transcription factors (TFs) andcis-regulatory elements through interacting with target sequences and recruiting epigenetic regulators. By integration of enhancer profiling and chromatin accessibility, we establish super-enhancer (SE) mediated core regulatory circuitry (CRC) for esophageal squamous cell carcinoma (ESCC) and identify tumor cells-dependent CRC TFs-TP63, SOX2 and KLF5. They preferentially co-occupy SE loci and form a positive interconnected auto-regulatory loop through SEs to orchestrate chromatin and transcriptional programming. SE-associated oncogene-ALDH3A1is identified as a novel CRC target contributing to ESCC viability. Using circular chromosome conformation capture sequencing (4C-seq) and CRISPR/Cas9 genome editing, the direct interaction betweenTP63promoter and functional enhancers which is mediated by CRC TFs is identified. Deletion of each enhancer decreases expression of CRC TFs and impairs cell viability, phenocopying the knockdown of each CRC TF. Targeting epigenetic regulation by inhibition of either the BET bromodomain or HDAC disrupts the CRC program and its dependent global epigenetic modification, consequently suppressing ESCC tumor growth. Importantly, combination of both compounds result in synergistic anti-tumor effect.Graphical AbstractHIGHLIGHTSSuper-enhancers mediated transcriptional regulatory circuitry is established for ESCCTP63, SOX2 and KLF5 as CRC TFs co-localize super-enhancer loci to orchestrate chromatin accessibility and transcriptional dysregulationComplex interaction between functional enhancers andTP63promoter is mediated by CRC TFsALDH3A1is a key downstream target of ESCC CRC and is essential for ESCC cell survivalBET degrader-ARV-771 and HDAC inhibitor-Romidepsin synergistically inhibit ESCC tumor growth
The Academic Career Readiness Assessment: Clarifying training expectations for future life sciences faculty
Authors: Clement Laurence , Dorman Jennie B. , McGee Richard 
Published: November 2019

AbstractWe describe here the development and validation of the Academic Career Readiness Assessment (ACRA) rubric, an instrument that was designed to provide more equity in mentoring, transparency in hiring, and accountability in training of aspiring faculty in the life sciences. We report here the results of interviews with faculty at 20 U.S. institutions which resulted in the identification of 14 qualifications and levels of achievement required for obtaining a faculty position at three groups of institutions: research-intensive (R), teaching-only (T), and research and teaching-focused (RT). T institutions hire candidates on teaching experience and pedagogical practices, and on their ability to serve diverse student populations. RT institutions hire faculty on both research and teaching-related qualifications, as well as on the ability to support students in the laboratory. R institutions hire candidates mainly on their research achievements and potential, which may limit the diversification of the life science academic pathway.
Tandem electrospinning for heterogeneous nanofiber patterns
Authors: Wieringa Paul , Truckenmuller Roman , Micera Silvestro , van Wezel Richard , Moroni Lorenzo 
Published: November 2019

AbstractSmart nanofibrillar constructs can be a promising technological solution for many emerging and established fields, facilitating the potential impact of nano-scale strategies to address relevant technological challenges. As a fabrication technique, electrospinning (ESP) is relatively well-known, accessible, economic, and fast, though until now has shown limitation over control and design of the fibrillar constructs which can be produced. Here, we introduce “Tandem Electrospinning” (T-ESP), a novel technique able to create increasingly complex patterns of fibrous polymeric constructs on a micro and nano-scale. Modifying a standard ESP configuration results in a focusing electric field that is able to spatially define the deposition pattern of multiple polymer jets simultaneously. Additional spatially defined heterogeneity is achieved by tuning polymer solution properties to obtain a gradient of fiber alignment. Heterogeneous fibrous meshes are created with either random, aligned, or a divergent fiber patterns. This approach holds potential for many fields, with application examples shown for Tissue Engineering and Separation Technologies. The technique outlined here provides a rapid, versatile, and accessible method for polymeric nanofabrication of patterned heterogeneous fibrous constructs. Polymer properties are also shown to dictate fiber alignment, providing further insight into the mechanisms involved in the electrospinning fabrication process.
The natural compound Notopterol targets JAK2/3 to ameliorate macrophage-induced inflammation and arthritis
Authors: Wang Qiong , Zhou Xin , Yang Long , Zhao Yongjian , Xiao Jun , Shi Qi , Liang Qianqian , Wang Yongjun , Wang Hongyan 
Published: November 2019

Abstract:Notopterol (NOT) is one of the main constituents of the traditional Chinese medicinal herbNotopterygium incisum Ting ex H.T. Changhas anti-rheumatism activity, but the target of NOT remains unknown. Here we have demonstrated that orally or intraperitoneal administration of NOT exhibits significant therapeutic effects on the collagen-induced arthritis (CIA) model in both DBA/1J and C57/BL6 mice. NOT treatmentin vivoandin vitroreduces production of inflammatory cytokines and chemokines in TNFα- or LPS/IFNγ-stimulated macrophages via blocking the JAK2/3-STAT3/5 activation. Mechanistically, NOT directly binds JAK2 to inhibit its activity via Arg980, Asn981, and Leu932 in the JH1 domain. Importantly, expression of the L938A/R980A/N981A mutant in zebrafish significantly inhibited thein vivoinflammatory response after LPS injection, which showed no further inhibitory effect upon NOT treatment. Combination of NOT and an anti-TNFα antibodies could achieve a better therapeutic effect than anti-TNFα alone in the CIA model. We therefore suggest that as a specific JAK2/3 inhibitor, the natural compound NOT ameliorates pathology of RA, which might be useful to treat other JAK2/3-related diseases.
PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia
Authors: Yamaguchi Norihiro , Weinberg Ethan M , Nguyen Alexander , Liberti Maria V , Goodarzi Hani , Janjigian Yelena Y , Paty Philip B , Saltz Leonard B , Kingham T Peter , Loo Jia Min , de Stanchina Elisa , Tavazoie Sohail F 
Published: November 2019

AbstractColorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to metastatic organ colonization, with liver being the primary organ affected. We modeled metastatic CRC (mCRC) liver colonization using patient-derived primary and metastatic tumor xenografts (PDX). Such PDX modeling predicted patient survival outcomes.In vivoselection of multiple PDXs for enhanced metastatic capacity upregulated the gluconeogenic enzyme PCK1, which enhanced metastatic hypoxic survival by driving anabolic pyrimidine nucleotide biosynthesis. Consistently, highly metastatic tumors upregulated multiple pyrimidine biosynthesis intermediary metabolites. Therapeutic inhibition of the pyrimidine biosynthetic enzyme DHODH with oral leflunomide substantially impaired CRC liver metastatic colonization and hypoxic survival. Our findings provide a potential mechanistic basis for the epidemiologic association of anti-gluconeogenic drugs with improved CRC metastasis outcomes, reveal the exploitation of a gluconeogenesis enzyme for pyrimidine biosynthesis during hypoxia, and implicate DHODH and PCK1 as metabolic therapeutic targets in colorectal cancer metastasis.
Changes in spinal cord hemodynamic reflect modulation of spinal network with different parameters of epidural stimulation
Authors: Tang Shanshan , Cuellar Carlos A. , Song Pengfei , Islam Riazul , Huang Chengwu , Wen Hai , Knudsen Bruce E. , Gong Ping , Lok U-Wai , Chen Shigao , Lavrov Igor A. 
Published: November 2019

AbstractIn this study functional ultrasound (fUS) imaging has been implemented to explore the local hemodynamic response induced by electrical epidural stimulation and to study real-time in vivo functional changes of the spinal cord, taking advantage of the superior spatiotemporal resolution provided by fUS. By quantifying the hemodynamic and electromyographic response features, we tested the hypothesis that the transient hemodynamic response of the spinal cord to electrical epidural stimulation could reflect modulation of the spinal circuitry and accordingly respond to the changes in parameters of electrical stimulation. The results of this study for the first time demonstrate that the hemodynamic response to electrical stimulation could reflect functional organization of the spinal cord. Response in the dorsal areas to epidural stimulation was significantly higher and faster compared to the response in ventral spinal cord. Positive relation between the hemodynamic and the EMG responses was observed at the lower frequencies of epidural stimulation (20 and 40 Hz), which according to our previous findings can facilitate spinal circuitry after spinal cord injury, compared to higher frequencies (200 and 500 Hz). These findings suggest that different mechanisms could be involved in spinal cord hemodynamic changes during different parameters of electrical stimulation and for the first time provide the evidence that functional organization of the spinal cord circuitry could be related to specific organization of spinal cord vasculature and hemodynamic.Significance StatementElectrical epidural stimulation (EES) has been successfully applied to control chronic refractory pain and was evolved to alleviate motor impairment after spinal cord injury, in Parkinson’s disease, and other neurological conditions. The mechanisms underlying the EES remain unclear, and current methods for monitoring EES are limited in sensitivity and spatiotemporal resolutions to evaluate functional changes in response to EES. We tested the hypothesis that the transient hemodynamic response of the spinal cord to EES could reflect modulation of the spinal cord circuitry and accordingly respond to the changes in parameters of EES. The proposed methodology opens a new direction for quantitative evaluation of the spinal cord hemodynamic in understanding the mechanisms of spinal cord functional organization and effect of neuromodulation.
Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival
Authors: Coomer Cagney E. , Wilson Stephen G. , Titialii-Torres Kayla F. , Bills Jessica D. , Krueger Laura A. , Petersen Rebecca A. , Turnbaugh Evelyn M. , Janesch Eden L. , Morris Ann C. 
Published: November 2019

AbstractThe intrinsic and extrinsic factors that regulate vertebrate photoreceptor specification and differentiation are complex, and our understanding of all the players is far from complete. Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-orange (bHLH-O) transcriptional repressor that regulates neurogenesis in several developmental contexts. We have previously shown thather9is upregulated during chronic rod photoreceptor degeneration and regeneration in adult zebrafish, but little is known about the role ofher9during retinal development. To better understand the function of Her9 in the retina, we generated zebrafishher9CRISPR mutants.Her9homozygous mutants displayed striking retinal phenotypes, including decreased numbers of rods and red/green cones, whereas blue and UV cones were relatively unaffected. The reduction in rods and red/green cones correlated with defects in photoreceptor subtype lineage specification. The remaining rods and double cones displayed abnormally truncated outer segments, and elevated levels of apoptosis. In addition to the photoreceptor defects,her9mutants also possessed a reduced proliferative ciliary marginal zone, and decreased and disorganized Müller glia. Mutation ofher9was larval lethal, with no mutants surviving past 13 days post fertilization. Our results reveal a previously undescribed role for Her9/Hes4 in photoreceptor differentiation, maintenance, and survival.
Maize Stem Buckling Failure is Dominated by Morphological Factors
Authors: Stubbs Christopher J , Larson Ryan , Cook Douglas D 
Published: November 2019

AbstractThe maize (Zea mays) stem is a biological structure that must both balance biotic and structural load bearing duties. These competing requirements are particularly relevant in the design of new bioenergy crops. With the right balance between structural and biological activities, it may be possible to design crops that are high-yielding and have digestible biomass. But increased stem digestibility is typically associated with a lower structural strength and higher propensity for lodging. This study investigates the hypothesis that geometric factors are much more influential in determining structural strength than tissue properties. To study these influences, both physical and in silico experiments were used. First, maize stems were tested in three-point bending. Specimen-specific finite element models were created based on x-ray computed tomography scans. Models were validated by comparison with in vitro data. As hypothesized, geometry was found to have a much stronger influence on structural stability than material properties. This information reinforces the notion that deficiencies in tissue strength could be offset by manipulation of stalk morphology, thus allowing the creation of stalks with are both resilient and digestible.HighlightThis study utilized physical and in silico experiments to confirm that geometric parameters are far more influential in determining stalk strength than mechanical tissue stiffnesses.
Nonrigid point set registration based on Laplace mixture model with local constraints
Authors: Xu Chao , Yang Xianqiang , Liu Xiaofeng 
Published: November 2019

PurposeThis paper aims to investigate a probabilistic mixture model for the nonrigid point set registration problem in the computer vision tasks. The equations to estimate the mixture model parameters and the constraint items are derived simultaneously in the proposed strategy.Design/methodology/approachThe problem of point set registration is expressed as Laplace mixture model (LMM) instead of Gaussian mixture model. Three constraint items, namely, distance, the transformation and the correspondence, are introduced to improve the accuracy. The expectation-maximization (EM) algorithm is used to optimize the objection function and the transformation matrix and correspondence matrix are given concurrently.FindingsAlthough amounts of the researchers study the nonrigid registration problem, the LMM is not considered for most of them. The nonrigid registration problem is considered in the LMM with the constraint items in this paper. Three experiments are performed to verify the effectiveness and robustness and demonstrate the validity.Originality/valueThe novel method to solve the nonrigid point set registration problem in the presence of the constraint items with EM algorithm is put forward in this work.
Accounting as a tool of state ideology to control captive workers from a House of Correction
Authors: Silva Adriana Rodrigues , Rodrigues Lúcia Lima , Sangster Alan 
Published: November 2019

Purpose
The purpose of this paper is to interpret the use of accounting information relating to the House of Correction, a public safety institution established in Rio de Janeiro for the control of workers under a tutelage system (1831–1864). The aim of the House of Correction was to develop a disciplined workforce of former slaves and other “Free Africans”. Various control and information procedures were put in place to monitor its achievement of this goal.

Design/methodology/approach
This study is based on historical archival research, mainly conducted at the National Archive of Rio de Janeiro and at the Brazilian National Library. The study uses Althusser’s ideology concept and the Marxist concept of reproduction of labour to show how accounting information enabled the administrator of the House of Correction to exercise control over the “Free Africans” consistent with the ideologies of the period and place.

Findings
The authors find that the House of Correction pursued a policy of ensuring “Free Africans” were docile, obedient and familiar with State ideology.

Research limitations/implications
The research is based on a single case study and it shows the need for both comparative and interdisciplinary analysis in order to increase an understanding of the use of accounting information in ancient prison contexts, as well as in contemporary situations.

Originality/value
This paper extends our knowledge of the use of accounting for the control of workers, who were either captive or repressed due to their ethnical differences; and it shows how ideology can be imposed through the use of accounting information. The authors extend theory by applying the Marxist and Althusserian concept of reproduction of labour to the case of “Free Africans”.