bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conflict Inflation: Keynesian Path Dependency or Marxian Cumulation?
Authors: Skott Peter 
Published: December 2024

ABSTRACTNotions of conflict inflation have been central to neo‐Marxian and post‐Keynesian economics. There are tensions, however, within the Marxian/post‐Keynesian camp. Post‐Keynesians emphasize weak feedback effects between price and wage inflation, thereby preserving the importance of aggregate demand in the determination of output and employment in the medium and long run. Like Kalecki in his famous analysis of “Political aspects of full employment”, Marxists typically suggest, on the contrary, that if unemployment is kept low, cumulative increases in workers' power and militancy imply severe limitations of aggregate demand policy in the long run. The paper discusses these rival perspectives and their implications, suggesting that (i) valid Marxian concerns are likely to derail ambitious reform programs that rely on fiscal expansion, (ii) Kalecki's analysis failed to recognize the centrality of inflation for aggregate demand policy and the multidimensional character of class conflict, and (iii) rather than focus on the wage struggle, labor movements may benefit from prioritizing political and institutional change.
Systematic review of the efficacy of yoga and mindfulness in the management of pediatric obesity
Authors: López‐Alarcón Mardia , Villasis‐Keever Miguel A. , Fernández José R. 
Published: December 2024

AbstractThe neuroplasticity of adolescents could make them responsive to interventions affecting brain maturation such as yoga and mindfulness. We aimed to determine their efficacy and safety for the management of children and adolescents with obesity. A systematic search using MEDLINE, EMBASE, and PsycInfo was performed up to March 2024. We considered randomized controlled trials (RCTs) using yoga or mindfulness alone (or combined with standard therapy) compared to placebo, nothing, or standard therapy for weight loss. Methodological quality of studies was assessed with the Risk of Bias 2 tool. The primary outcomes were changes in weight and adiposity (kg, body mass index [BMI], BMI z‐score, fat mass, waist circumference, waist‐to‐hip ratio). We assessed 4 yoga and 7 mindfulness RCTs, including 620 participants 8–19 years old. The number of participants varied per type of intervention (yoga, n = 10–63; mindfulness, n = 11–47). Comparators were no‐intervention or active controls. All yoga trials reported anthropometric improvements, but all trials combined yoga with extra physical activity. Five out of seven mindfulness trials reported anthropometric improvements. The methodological quality of the RCTs was low. No safety information was reported. The effect of yoga and mindfulness on psychological and metabolic variables was inconsistent. This evidence is insufficient to recommend yoga or mindfulness for the management of adolescents with obesity.
Exploring the implementation of a novel, transdiagnostic, hybrid ecological momentary intervention for improving resilience in youth (EMIcompass): A process evaluation in the realist framework
Authors: Paetzold Isabell , Gugel Jessica , Schick Anita , Rauschenberg Christian , Hirjak Dusan , Boecking Benjamin , Doi Lawrence , Schwannauer Matthias , Reininghaus Ulrich 
Published: December 2024

AbstractObjectivesPrevious research indicates that the hybrid compassion‐focused intervention EMIcompass may reduce stress reactivity and improve quality of life. Our aim was to investigate what components of the intervention work for whom, how, and under which circumstances to contribute to the enhancement of resilience.MethodsWe conducted a process evaluation using a realist framework. First, we developed initial programme theories using compassion‐focused interventions and ecological momentary intervention documents, in addition to conducting a focus group and an interview with an individual expert. Second, we tested the initial programme theories based on qualitative data from 20 participants. Third, we refined the programme theories by analysing and interpreting the data.ResultsWe identified four programme components experienced as enhancing the activation of the soothing system and the application of compassion‐focused principles. EMIcompass was perceived as lowering the burden of and barriers to treatment and facilitating the translation into daily life. Intra‐ and interpersonal context factors interacted with the mechanisms, leading to improvement in well‐being, which was identified as a main outcome.DiscussionThe intervention worked by strengthening participants' soothing system and facilitating ecological translation leading to improved well‐being. Adaptions to improve the intervention may allow for more flexibility in individual intervention trajectories acknowledging different needs and preferences.
Splenomegaly and progressive neurologic involvement: Think about Niemann–Pick type C disease
Authors: Yoldas Celik Merve , Yazici Havva , Erdem Fehime , Yuksel Yanbolu Ayse , Canda Ebru , Sezer Ebru , Kalkan Ucar Sema , Onay Huseyin , Ozkinay Ferda , Yildirim Sozmen Eser , Coker Mahmut 
Published: December 2024

AbstractBackgroundNiemann–Pick type C (NPC) disease is a lysosomal storage disease with visceral organ involvement and neurological and psychiatric symptoms. This study presents the clinical and laboratory findings of NPC cases involving three novel variants.MethodsThe clinical and laboratory findings were reviewed retrospectively between February 2006 and December 2022.ResultsThere were nine females and five males. The median age of diagnosis of the patients was 5 months (range: 1 month to 38 years). The clinical phenotypes of the patients were early infantile (n = 7), late infantile (n = 4), juvenile (n = 2), and adult (n = 1). The visceral findings were splenomegaly (100%), hepatomegaly (78.6%), neonatal jaundice (42.8%), and hepatic failure (14.3%). The neurological findings were developmental delay (71.4%), seizures (50%), vertical supranuclear gaze palsy (28.6%), ataxia (28.6%), dysarthria (28.6%), dysphagia (21.4%), dystonia (21.4%). Cataplexy (14.3%) and psychiatric manifestations (14.3%) were recorded in juvenile and adult‐onset patients. Three novel variants were detected (p.Asn524LysfsTer39, p.Val1023Phe, and p.Asn906Tyr). Miglustat treatment was received by 64.3% of patients but had no clear effect on the disease course. The median duration of use was 3 years (with a range from 1–13 years). Miglustat's adverse effects were low platelet count (35.7%) and diarrhea (7.1%).ConclusionsNiemann–Pick type C disease should be considered in the presence of visceral organ involvement and progressive neurological findings. It is essential to support the diagnosis with laboratory and genetic analysis.
The Novel Allele, HLA‐C*06:391, Identified by Next Generation Sequencing in a Saudi Individual
Authors: AlAbduladheem Dalal , Alharbi Hassan , AlZahrani Saber , Mohammed Amani , Awaji Mohammad 
Published: December 2024

ABSTRACTA single nucleotide substitution in exon 2 of HLA‐C*06:02:01:01 results in the novel allele, HLA‐C*06:391.
Prediction of dual-phenotype hepatocellular carcinoma based on ultrasound and contrast enhanced ultrasound – a preliminary study
Authors: Wang Nan , Lv Xiaorong , Wang Peihua , Huang Xiao , Liu Luping , Zhu Ju , Nie Fang 
Published: December 2024

Aims: To investigate the diagnostic value of ultrasound features with dual-phenotype hepatocellular carcinoma (DPHCC). Material and methods: A retrospective analysis was conducted on patients diagnosed with hepatocellular carcinoma (HCC) confirmed by pathology results from October 2016 to December 2023. Patients were categorized into DPHCC and non-DPHCC (NDPHCC) groups based on immunohistochemical findings. Clinical baseline characteristics and ultrasound features were compared between these groups. Multivariable logistic regression was employed to identify predictive factors. A logisticregression model and nomogram were developed to predict DPHCC.Results: This study included 219 HCC patients (average age: 55.84±9.00, 173 males), with 61 cases of DPHCC and 158 cases of NDPHCC. The results of multivariate logistic regression indicated that halo sign (OR=1.93, p=0.049), PVP hypo-enhancement (OR=2.73, p=0.002) and nodule-in-nodule sign (OR=4.23, p=0.003) were independent predictors of DPHCC. The model’s AUC value was 0.73 (95%CI: 0.65-0.80). The calibration curve displayed good predictive accuracy.Conclusions: Ultrasound features, including CEUS, may provide additional information for the non-invasive diagnosis of DPHCC.
Using Accelerometer Fragmentation Metrics to Compare Temporality of Preschoolers’ Indoor and Outdoor Free Play
Authors: Clevenger Kimberly A. , McKee Katherine L. , Pfeiffer Karin A. 
Published: December 2024

Children’s play includes brief and intermittent physical activity (PA) interspersed with rest, but there is a lack of recent research confirming this assumption. Accelerometer-derived fragmentation metrics are a potential tool for characterizing the temporality of children’s movement that have not yet been used in this population. Purpose: The present study describes the accelerometer-measured temporality of indoor and outdoor free play during preschool. Methods: Children (n = 44, 3–5 years) wore a hip-worn accelerometer for one indoor and one outdoor free-play session. Mean and median duration of total PA (TPA) and moderate-to-vigorous PA (MVPA) bouts and probabilities of transitioning between inactivity and TPA or MVPA were calculated using two sets of cut points. Indoor and outdoor PA were compared using paired t tests adjusted for multiple comparisons, Cohen’s d effect sizes, and correlation coefficients (r). Results: Outdoor TPA (55.9%–63.9% depending on the cut point used) and MVPA (23.3%–50.3%) were significantly higher than indoor TPA (40.3%–49.1%) or MVPA (13.9%–34.9%) (d = 0.67–0.83). In addition, children’s outdoor play was characterized by longer bout durations (3–10 vs. 2–6 s; d = 0.79–0.86), and lower probabilities of transitioning from activity to inactivity (3.6%–15.3% vs. 7.6%–23.5%; d = 0.86–1.00) compared with indoor play. Higher MVPA was associated with less fragmented activity as represented by longer bout durations (r = .27–.83) and a higher probability of transitioning from inactivity to activity (r = .45–.75). Discussion: Our findings confirm that children’s free play is highly transient and includes very short bouts of both TPA and MVPA. Identifying ways to promote sustained PA is a potential avenue for interventionists.
A Consensus Method for Estimating Moderate to Vigorous Physical Activity Levels in Adults Using Wrist-Worn Accelerometers
Authors: Clevenger Kimberly A. , McNarry Melitta A. , Mackintosh Kelly A. , Pfeiffer Karin A. , Nelson M. Benjamin , Bock Joshua M. , Imboden Mary T. , Kaminsky Leonard A. , Montoye Alexander H.K. 
Published: December 2024

Inconsistency in the calculation of time spent in moderate to vigorous physical activity (MVPA) limits interstudy comparability and interpretation of surveillance data. This study assesses whether combining multiple individual methods results in a more accurate estimate of MVPA, while considering the influence of device brand and wear location. Participants (n = 30, age = 49.2 ± 19.5 years) wore two accelerometers (GENEActiv, ActiGraph) on each wrist during two laboratory visits. Individual classification methods (11 for left wrist, eight for right wrist) estimated minutes of MVPA using three approaches (cut-point, two-regression, and machine learning), two types of input (count and raw), and five epoch lengths (1, 5, 15, 30, and 60 s). The consensus estimate was calculated as the mean or median (due to skew) across all individual estimates. No individual or consensus estimates were statistically equivalent to direct observation (mean 38.2 min), with 81%–95% of individual methods overestimating MVPA. The best-performing individual methods were raw acceleration cut-points, with a bias of −3.2 to 2.4 min across devices and wrists. Correlation coefficients between individual methods and the criterion were .35–.71 for the left and .12–.67 for the right wrist, compared to .65–.70 and .58–.66 for consensus methods, respectively. Correlations between device brands were .23–.99 for individual methods and .70–.86 for consensus methods, while correlations between locations were .55–.86 and .73–.87, respectively. Better methods are required for estimating MVPA from wrist-worn accelerometers given the consistent overestimation of MVPA observed. While a consensus method for wrist-worn data was not able to fully resolve these issues, it improves interwrist or interbrand comparability.
The
Legionella pneumophila
effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT
Authors: Mount Harley O'Connor , Urbanus Malene L. , Zangari Francesco , Gingras Anne-Claude , Ensminger Alexander W. 
Published: December 2024

ABSTRACT

The eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen. We show that a translocated bacterial effector protein, PieF (Lpg1972) of
Legionella pneumophila
, directly interacts with the CNOT7/8 nuclease module of CCR4−NOT, with a dissociation constant in the low nanomolar range. PieF is a robust
in vitro
inhibitor of the DEDD-type nuclease, CNOT7, acting in a stoichiometric, dose-dependent manner. Heterologous expression of PieF phenocopies knockout of the CNOT7 ortholog (POP2) in
Saccharomyces cerevisiae
, resulting in 6-azauracil sensitivity. In mammalian cells, expression of PieF leads to a variety of quantifiable phenotypes: PieF silences gene expression and reduces mRNA steady-state levels when artificially tethered to a reporter transcript, and its overexpression results in the nuclear exclusion of CNOT7. PieF expression also disrupts the association between CNOT6/6L EEP-type nucleases and CNOT7. Adding to the complexities of PieF activity
in vivo
, we identified a separate domain of PieF responsible for binding to eukaryotic kinases. Unlike what we observe for CNOT6/6L, we show that these interactions can occur concomitantly with PieF’s binding to CNOT7. Collectively, this work reveals a new, highly conserved target of
L. pneumophila
effectors and suggests a mechanism by which the pathogen may be modulating host mRNA stability and expression during infection.

IMPORTANCE

The intracellular bacterial pathogen
Legionella pneumophila
targets conserved eukaryotic pathways to establish a replicative niche inside host cells. With a host range that spans billions of years of evolution (from protists to humans), the interaction between
L. pneumophila
and its hosts frequently involves conserved eukaryotic pathways (protein translation, ubiquitination, membrane trafficking, autophagy, and the cytoskeleton). Here, we present the identification of a new, highly conserved host target of
L. pneumophila
effectors: the CCR4−NOT complex. CCR4−NOT modulates mRNA stability in eukaryotes from yeast to humans, making it an attractive target for a generalist pathogen, such as
L. pneumophila
. We show that the uncharacterized
L. pneumophila
effector PieF specifically targets one component of this complex, the deadenylase subunit CNOT7/8. We show that the interaction between PieF and CNOT7 is direct, occurs with high affinity, and reshapes the catalytic activity, localization, and composition of the complex across evolutionarily diverse eukaryotic cells.
Synthesis of Dipolar Chromophores Based on Polyfluorinated Triphenyl-4,5-dihydro-1H-pyrazoles and Dicyanoisophorone with a Thiophene Fragment in the Polymethine Chain
Authors: Shelkovnikov V. V. , Ishchenko A. V. , Kargapolova I. Yu. , Orlova N. A. 
Published: December 2024

Abstract
A series of donor–acceptor polymethine dyes containing a polyfluorinated triphenyl-4,5-dihydro-1H-pyrazole fragment as donor moiety, dicyanoisophorone fragment as acceptor moiety, and polymethine chain including a thiophene fragment have been synthesized as potential nonlinear optical chromophores. The electronic absorption spectra of the synthesized dyes showed a long-wavelength maximum at λ 540–550 nm, which is shifted by 40 nm to the red region compared to their analogues without a thiophene bridge. The dyes displayed luminescence in chloroform solution with an emission maximum at λ 740–760 nm and a Stokes shift of 200–210 nm (5000 cm–1).
Quantum Chemical Study of Mechanisms of Organic Reactions: XIII. Reaction of Propargyl Chloride with Dipotassium Ethane-1,2-bis(thiolate) in the System Hydrazine Hydrate–Potassium Hydroxide. Heterocyclization Pathways
Authors: Chirkina E. A. , Grabelnykh V. A. , Korchevin N. A. , Krivdin L. B. , Rozentsveig I. B. 
Published: December 2024

Abstract
The reaction of propargyl chloride with ethane-1,2-bis(thiolate) in the system hydrazine hydrate–potassium hydroxide has been simulated using the combined CCSD(T)/6-31+G*//B3LYP/6-311++G** approach. Elementary steps of the process and possible heterocyclization pathways of the primary intermediates have been identified. Under experimental conditions (40–42°C, 6 h), the title reaction produced 25% of 2-methyl-5,6-dihydro-1,4-dithiine and 24% of 4,7-dithiadeca-2,8-diyne. No cyclic products were formed at –10 to –15°C.
(Invited) Integrating Biology and Technology: Unleashing the Power of Graphene Field Effect Transistors
Authors: Aran Kiana 
Published: December 2024

As we deepen our understanding of biological machineries, we increasingly recognize the mechanisms at work within living organisms and the vast potential these biological systems offer for technological innovation. The fusion of biological machineries with cutting-edge technology has the potential to create a new era of solutions to some of the most pressing challenges facing humanity today. The integration of biological machineries with field effect nano biosensing technologies, opens up unprecedented avenues for advancements in healthcare, monitoring, biosecurity, and much more.
Graphene Field Effect Transistors (gFETs) stand at the forefront of this interdisciplinary journey. gFETs are highly sensitive to changes in their electrical environment, making them ideal for detecting biological signals. Graphene, a single layer of carbon atoms arranged in a hexagonal lattice, exhibits remarkable electrical, mechanical, and optical properties. Its high conductivity, flexibility, and surface area make it an excellent material for biosensing applications. When biological molecules bind to graphene's surface, they induce a change in its electrical properties, which can be precisely measured by the gFET. This sensitivity to electrical changes at the molecular level enables the direct detection of biological entities without the need for labeling or amplification, offering real-time monitoring capabilities.
This talk will highlight the fusion of gFET technology with biology to offer novel approaches to detecting genetic mutations and volatile organic compounds with high sensitivity and specificity. By functionalizing graphene's surface with biological receptors or molecules, such as those used in CRISPR-Cas9 systems or odorant receptors, gFETs can directly detect target DNA sequences or distinguish complex odor profiles without the need for traditional, complex laboratory procedures. The integration of gFET technology with biological specificity is a testament to the transformative potential at the intersection of biology and technology, opening new avenues for innovation in healthcare and beyond.

Figure 1
Scaling up Solid State Battery Research at Fraunhofer FFB
Authors: Zahnow Julian , Schmuch Richard 
Published: December 2024

All-solid-state batteries (ASSBs) hold immense promise for revolutionizing the future of energy storage due to their enhanced safety and higher potential energy density. Within the context of the federally funded FoFeBat project dedicated to production research for batteries, this abstract outlines the overarching goals and collaborative strategies of the Fraunhofer Research Institution for Battery Cell Production FFB in advancing ASSB production.
In five designated so-called innovation laboratories, which are run in close collaboration with some of the leading academic battery research institutions in Germany, including Universities of Muenster, Giessen and Aachen, as well as Research Center Juelich (FZJ), Fraunhofer FFB addresses the problems in scaling up solid state battery and solid electrolyte production. The planned research activities include upscaling the synthesis of polymer-, oxide- and thiophosphate-based solid electrolytes to the kg-scale. The in-house produced materials are used to study the production process of ASSB electrodes with different cathode active materials and how different forms of pressure application (warm-isostatic pressing, calendaring) influence the resulting electrode composite. This includes the evaluation of the influence of different binder materials and solvents on the production process of the electrodes. For the cell assembly, a prototype-scale production line will be established, where the different sheets (electrodes, separator) will be combined, and environmental influences can be studied by the application of sealed mini environments at the different assembly steps. The finalized cells are electrochemically characterized to study the influence of different operating conditions (temperature, pressure) on the cell performance. In addition to this, safety evaluation of the different materials and the fully assembled cells is part of this project. The establishment of the innovation laboratories for ASSB research provide the unique opportunity to test the acquired parameters on the pilot scale production line of the Fraunhofer FFB, which will help to evaluate the transferability of the different production steps into a full-scale lithium-ion-battery production line at FFB.
Scaling up these processing steps will produce challenges that are currently being investigated by various companies without the possibility of accessing the acquired knowledge. Solving these challenges and making the obtained knowledge publicly available through scientific journal publications, will help speed up the development of solid-state batteries.