bluuebunny/crossref_metadata_2025_split huggingface dataset:
Korelasi Karakteristik Individu Terhadap Tingkat Depresi Pada Pasien Gagal Ginjal Kronik
Authors: Rahman Havizur , Arifin Helmi , Murni Arina Widya 
Published: December 2019

ABSTRAK Pasien dengan penyakit kronis memiliki kecendrungan mengalami depresi, salah satunya pada pasien gagal ginjal kronis. Tujuan: mengetahui korelasi antara karakteristik pasien gagal ginjal kronis dengan terjadinya depresi. Metode penelitian: cross sectional menggunakan data primer, dengan teknik pengambilan data judgment sampling, pengukuran tingkat depresi menggunakan Beck Depression Inventory-II (BDI- II) dan data dianalisis menggunakan uji korelasi kendall’s tau-b. Hasil: karakteristik umur (sig=0.057), tingkat Pendidikan (sig=0.246), status (sig=0.484), jaminan kesehatan (sig=0.957) dan lama menjalani tindakan hemodialisis (sig=0,396) tidak memiliki hubungan dengan terjadinya depresi sedangkan karaktersitik yang memiliki hubungan dengan terjadinya depresi yaitu jenis kelamin (sig=0.028), pekerjaan (sig= 0.001) dan tindakan hemodialisa (sig= 0.05) dengan korelasi cukup kuat. Kesimpulan: beberapa karakteristik pasien yaitu jenis kelamin, pekerjaan dan tindakan hemodialisa memiliki korelasi yang cukup kuat terhadap timbulnya depresi pada pasien gagal ginjal kronis. Kata Kunci— korelasi, karaktersitik, depresi ABSTRACT Patients with chronic diseases have a tendency to experience depression, one of them is in patients with chronic kidney failure. Objective: to determine the correlation between the characteristics of patients with chronic kidney failure with depression. Research methods: cross sectional using primary data, with judgment sampling data collection techniques, measurement of depression levels using the Beck Depression Inventory-II (BDI-II) and data analyzed using the Kendall's tau-b correlation test. Results: age characteristics (sig = 0.057), education (sig = 0.246), status (sig = 0.484), health insurance (sig = 0.957) and length of time undergoing hemodialysis (sig = 0.396) have no relationship with the occurrence of depression while the characteristics of depression which has a relationship with the occurrence of depression, namely gender (sig = 0.028), work (sig = 0.001) and hemodialysis (sig = 0.05) with a strong enough correlation. Conclusion: some of the characteristics of patients namely sex, occupation and hemodialysis have a strong correlation to the onset of depression in patients with chronic kidney failure. Keywords — correlation, characteristics, depression
Pengaruh Hidroksi Propil Metil Selulosa Sebagai Polimer Mucoadhesiv Terhadap Sifat Fisik Patch Minyak Cengkeh (Syzygium aromaticum. L)
Authors: Lestari Pramulani Mulya , Yati Kori 
Published: December 2019

ABSTRAK Minyak cengkeh (Syzygium aromaticum) secara tradisional digunakan untuk untuk mengatasi masalah gigi dan mulut, pengembangan bentuk sediaan patch untuk mempertahankan zat aktif pada area gingival dan mencegah wash-out oleh saliva, polimer HPMC yang bersifat mukoadhesif mampu mampu berikatan pada mukosa mulu. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penggunaan HPMC (hidroksi Propil Metil Selulosa)sebagai polimer mucoadhesiv terhadap karakteristik fisik sediaan patch minyak cengkeh. Minyak cengkeh dibuat dalam bentuk sediaan emulsi m/a, yang selanjutnya ditambahkan dalam basis gel dengan variasi polimer HPMC yaitu 1 %; 1,5 %; 2 % dan dikeringkan. Patch yang terbentuk dievaluasi bobot rata – rata, pH, ketebalan, folding endurance, waktu tinggal dan swelling indeks. Hasil penelitian ini menunjukkan ketiga formula memiliki bobot rata- rata 21,33 – 29,63 mg pada ukuran 2 x 1 cm, pH 6, mampu bertahan lebih dari 250 lipatan, dan waktu tinggal 24 – 25 menit. Berdasarkan pada penelitian ini dapat disimpulkan konsentrasi HPMC mempengaruhi sifat fisik patch yang dihasilkan. Semakin tinggi konsentrasi HPMC maka bobot, ketebalan, waktu tinggal dan indeks mengembang patch juga semakin meningkat, sedangkan tidak terjadi perubahan pH dan kekuatan lipat pada variasi konsentrasi polimer 1 % - 2 % yang digunakan. Key word : HPMC, minyak cengkeh, patch ABSTRACT Clove oil (Syzygium aromaticum) has traditionally been used to overcome dental and oral problems, the development of patch dosage forms to maintain active substances in the gingival area and prevent wash-out by saliva, the mucoadhesive adhesive HPMC polymer capable of binding to the oral mucosa. The purpose of this study was to determine the effect of using HPMC (Hydroxy Propyl Methyl Cellulose) as a mucoadhesiv polymer on the physical characteristics of clove oil patch preparations. Clove oil is made in the form of m / a emulsion, which is then added to a gel base with a variation of polymer HPMC that is 1%; 1.5%; 2% and dried. The patches formed are evaluated for average weight, pH, thickness, folding endurance, residence time and index swelling. The results of this study indicate that the three formulas have an average weight of 21.33 - 29.63 mg at a size of 2 x 1 cm, pH 6, able to withstand more than 250 folds, and a residence time of 24-25 minutes. Based on this study it can be concluded the concentration of HPMC affects the physical properties of the resulting patch. The higher the concentration of HPMC, the weight, thickness, residence time and index of the swell patch also increased, while there was no change in pH and folding strength at variations in the polymer concentration of 1% - 2% used. Key word: HPMC, clove oil, patch
Efficiency of the Use of Humidified Gas Fuel and Oxidizing Mixture
Authors: Soroka B. S. , Vorobyov N. V. 
Published: December 2019

The influence of hydration of the components of combustion (air-oxidizer and – in some cases – fuel) including hydration in the conditions of substitution of natural gas by alternative gas fuels, viz. by coke blast furnace mixture and natural blast furnace mixture – on energy efficiency of the use of different fuels has been determined. Calculations of fuel saving for substitution of natural gas (NG) by wet process gas (blast furnace gas (BFG), coke gas (CG), their mixtures) were performed taking into account real technological parameters (on the example of a specific metallurgical plant). All the calculations were performed within the framework of the author’s methodology on fuel substitution grounded on the 1st and the 2nd laws of thermodynamics. The analysis of possibility for saving or overspending NG is performed in the conditions of preservation of the flow of the used total enthalpy (as the main requirement of the methodology that had been proposed) and of taking into account the corresponding efficiency of fuel use. The calculation of the required heat flow of natural gas combustion depending on the content of wet blast furnace gas in NG + BFG mixtures for the cases of NG substitution by process gases has been carried out. It is established that the presence of moisture in the fuel-oxidation mixture always reduces the efficiency of the combustion chamber or the energy process and the unit. In order to increase the efficiency of a high-temperature furnace (boiler), it is necessary to provide heating of combustion components when utilizing the heat of the outgoing combustion products. It is shown that the efficiency of the fuel-using system can be significantly increased when the potential (excess total enthalpy) of the working fluid (combustion products) is activated. There are additiоnal benefits due to the fact that the existing heat of products of combustion with humid air in a full range of temperatures – from the theoretical combustion temperature to ambient temperature under conditions of equilibrium, including account of the heat of condensation – increases with increasing moisture content of the initial components of combustion, viz. air-oxidizer and/or fuel gas.
Synthesis of Functionalized Silica from Rice Husks Containing C-I End Group
Authors: Et al. Sobh 
Published: December 2019

In this paper, we have extracted Silica from rice husk ash (RHA) by sodium hydroxide to produce sodium silicate. 3-(chloropropyl)triethoxysilane (CPTES) functionalized with sodium silicate via a sol-gel method in one pot synthesis to prepare RHACCl. Chloro group in compound RHACCl replacement in iodo group to prepere RHACI. The FT-IR clearly showed absorption band of C-I at 580 cm-1. Functionalized silica RHACI has high surface area (410 m2/g) and average pore diameter (3.8 nm) within mesoporous range. X-ray diffraction pattern showed that functionalized silica RHACI has amorphous phase .Thermogravemitric analysis (TGA) showed two decomposition stages and SEM morphology of RHACI showed that the particles have irregular shape. Atomic force microscope (AFM) technique was proved that the RHACI has a nanostructure The XPS spectra of I 3d for all the studied surfaces are presented in the peak located at 618.5 eV binding energy was associated with C–I bond.
Lifestyle factors and reversion to normoglycaemia by prediabetes type in PREDAPS study.
Authors: SORIANO LUCIA CEA , Giráldez-García Carolina , Albadalejo Romana , Franch-Nadal Josep , Mata-Cases Manel , Díez-Espino Javier , Artola Sara , Serrano Rosario , Regidor Enrique 
Published: December 2019

Abstract
Background There is little evidence on how healthy lifestyle factors can explain the variation in the proportion of patients reverting to normal glucose regulation according to type of prediabetesAims To study the role of lifestyle factors on the reversion to normal glucose regulation according to type of prediabetes.Design and Setting Observational prospective cohort study. The Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes from2012-2015Methods Participants were classified, according to the definition established by ADA using either fasting plasma glucose (FPG) levels between 100-125 mg/dL or HbA1c between 39-47 mmol/mol (5.7%–6.4%), in three groups. Reversion to normal glucose regulation was calculated at third year of follow-up. Relationship of lifestyle factor and type of prediabetes with reversion was estimated by means of Odds Ratios (OR) using three sequential models.Results Proportion of reversion rates were 31% for FPG group, 31% for HbA1c group and 7.9% for both altered parameters group, respectively. BMI<25 kg/m2[OR (95% CI): 1.90 (1.20-3.01)], high adherence to Mediterranean diet 1.78 (1.21-2.63) and absence of abdominal obesity 1.70 (1.19-2.43) were the strongest lifestyle predictors for reversion. Compared with those with both altered parameters, OR of reversion of prediabetes was 4.87 (3.10-7.65) for FPG group and 3.72 (2.39-5.78) for HbA1c group. These estimates remained almost the same after further adjustment for biochemical parameters and lifestyle factors.Conclusions Although optimal lifestyle factors showed to be a positive predictor, those do not seem to explain the differences according to the type of prediabetes.
Intracavitary and Extracavitary Iliac Extended Fixation Using Porous Metal Augments for Paprosky Type 3 Acetabular Defects in Revision Total Hip Arthroplasty: A Minimum 2 Years Follow-up
Authors: Tang Hao , Zhou Yixin , Ma Zhuyi , Huang Yong , Guo Shengjie 
Published: December 2019

Abstract
Background: We proposed a new concept of “iliac extended fixation” in revision total hip arthroplasty (THA) as fixation extending superiorly 2 cm beyond the original acetabular rim with porous metal augments, which was further classified into intracavitary and extracavitary fixation. This study reports the minimum 2 years outcome of the iliac extended fixation technique in patients with Paprosky type 3 acetabular defects. Methods: Thirty two revision THA patients were retrospectively reviewed who underwent reconstruction with the concept of iliac extended fixation from 2014 to 2016 in our hospital. Patients were assessed using the Harris Hip Score (HHS) and the Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC). In addition, radiographs were assessed and patient reported satisfaction was collected. Results: At an average follow-up of 40 months (range 25 – 64 months), the postoperative HHS and WOMAC scores were significantly improved at the last follow-up (p < 0.001). The postoperative horizontal and vertical locations of the COR were significantly improved from the preoperative measurements (p < 0.05). Two (6.3 %) patients were dissatisfied with the outcome. The extracavitary iliac extended fixation group had significantly more horizontal screws fixation (4.6 ± 25.7° vs 41.9 ± 37.8°, p < 0.001) and higher rate of osteointegration in zone 1A (91.7% vs 50.0%, p = 0.023) than the intracavitary iliac extended fixation group. Conclusions: Intracavitary and extracavitary iliac extended fixation with porous metal augments and cementless cups are effective in reconstructing severe superior acetabular bone defects, with promising short-term clinical and radiographic outcome.
Analysis of the potential correlation between gastric cancer and gastrointestinal microbiota via in-silico data mining
Authors: Ding Xuelu , Zhu Yukun , She Zhaoyuan , Liu Xuewen , Zhang Cancan , Ma Xuying , Wang Feng , Wang Fei , Geng Xin 
Published: December 2019

Abstract
Background: Emerging evidence shows the gastrointestinal microbiome might play an important role in the carcinogenesis of gastric cancer. While Helicobactor pylori has been reported to be a specific risk factor of gastric cancer, it is still controversial whether significant difference of non- H. pylori microbiota exists between gastric cancer patients and healthy control.Results: In this study, we employed multiple bioinformatic databases to excavate the potential correlation between gastrointestinal microbiome and gastric cancer. The databases involved in this investigation include HMDB, STITCH, OMIM, GWAS Catalog, WebGestalt, Toppgene, GeneMANIA. In addition, the network diagrams were built by use of Cytoscape software. Notably, our results showed that 33 common genes participate in both gastrointestinal microbiome and gastric cancer. The further analysis of these common genes suggested that there was a wide array of interactions and pathways in which the correlation between gastrointestinal microbiome and gastric cancer is involved.Conclusions: Our present study gives a bioinformatic insight into possible pathways in which the gastrointestinal microbiome play roles in gastric cancer. Future efforts are necessary to be paid to elicit the exact mechanisms as well as potential therapeutic targets of gastric cancer.
Myofibroblasts in Oral submucous fibrosis, Oral squamous cell carcinoma and Normal mucosa- an Immunohistochemical Analysis
Authors: Annamalai Sivachandran , Shamsudeen Shaik Mohamed , thavarajah Rooban , jousha Elizabeth , Rao Uma devi k , Kannan Ranganathan 
Published: December 2019

Abstract
Background: Myofibroblasts are spindle shaped smooth muscle like fibroblast involved in the physiological repair of tissue structure can also cause pathological remodeling of tissue by forming fibrosis. They express smooth muscle actin which can be evaluated for their biological behavior in the physiological and pathological conditions. Aim: To evaluate the expression of Myofibroblasts in oral submucous fibrosis, oral squamous cell carcinoma and normal mucosa by Immunohistochemical analysis. Methods: It is a cross-sectional study done to evaluate the expression of Myofibroblasts in oral submucous fibrosis (Group-1), oral squamous cell carcinoma (Group-2) and normal buccal mucosa (Group-3) using immunohistochemistry using alpha smooth muscle actin in formalin fixed, paraffin embedded tissue specimens. The localization of stain, nature of stain, intensity of stain and the percentage of cells stained among the three groups were studied and compared. Results: The gender distributions in the study were in favor of males. It was observed that Staining Intensity was seen more in group I (30%) than in group II (20%) and progressively increased from early (16.5%) to advance stage(50%) of oral submucous fibrosis. Higher staining intensity was observed in well differentiated oral squamous cell carcinoma. Conclusion: Myofibroblasts are important in normal healing process, but can induce fibrosis. In oral submucous fibrosis, they can be used to assess the severity of the lesion by their increased expression of alpha smooth muscle actin. In oral carcinogenesis increase in the number of alpha smooth muscle actin can change the distribution pattern results in tumor invasive characteristics. Key Words: Myofibroblasts, Alpha smooth muscle actin, Staining intensity, Oral Submucous Fibrosis, Oral Squamous Cell Carcinoma.
Aberrant expression of PD-1 on B cells and their subpopulations in systemic lupus erythematosus and association with clinical parameters
Authors: changhao xie , Lu Yang , Zhu Qingqing , Li Yun , Wang Qiyi , Jiang Chao , Li Zhijun , Wang Hongtao , Wang Yan , Zhang Wei , Wang Yuanyuan 
Published: December 2019

Abstract
Background: The binding of programmed death 1 (PD-1) with its ligands inhibits the T cell activation and proliferation. But role of the PD-1 pathway on B cells is unclear. In present study, we aimed to evaluate the expression of PD-1 on B cells and their subpopulations and association with clinical parameters in systemic lupus erythematosus (SLE).Results: The frequency of B cells increased significantly in patients with active SLE compared with healthy controls and patients with inactive SLE.The proportions of CD19+ IgD- CD27- cells andplasmablast cell among total B cells were significantly higher in patients with SLE compared with controls. The percentage of PD-1+ B cells was higher in patients with in active SLE than in healthy controls. The proportion of PD-1+ B cells was correlated with lupus nephritis, complement components, IgG, SLE Disease Activity Index, and autoantibodies. PD-1+ B cells from SLE showed a high proliferative response. The levels of IgG and anti-dsDNA secreted by PD-1+ B cells from SLE patients was higher after 7 days compared with that by PD-1- B cells from patients with SLE and healthy controls.Conclusions: The expression of PD-1 on B cells and their subpopulations was aberrant and was associated with clinical parameters in SLE.KEY WORDS:PD-1; B cells; subpopulation; systemic lupus erythematosus
Expression and Significance of protein 4.1R in rat models with diaphragmatic weakness
Authors: Li Yanhong , Li Yongqiang , Ji Xinying , Li Huimin , Wu Dongdong , Wei Wenqiang , Wang Xinchun 
Published: December 2019

Abstract
Abstract Background To explore the significance of protein 4.1R expression in the diaphragmatic weakness animal and cell models and its preliminary mechanism.Methods Rats were intraperitoneally injected with Lipopolysaccharide (LPS) to construct diaphragmatic weakness models. Histopathology of diaphragmatic tissues was detected by Hematoxylin eosin(HE) staining. L6 cells were induced by LPS to establish the myasthenic cell models and transfected with 4.1R-siRNA to konckdown 4.1R. Immunohistochemistry was performed to detect the expression of acetylcholine receptor(AchR) and 4.1R; The expression of desmin and myosin in tissues and cells were detected by western blot.Results LPS could induce the diaphragmatic weakness of rats. The expression of AchR in diaphragmatic weakness tissues was lower, while that of desmin was higher than that in the control group. 4.1R was up-regulated in the diaphragmatic weakness models, and related to the severity. After knockdown of 4.1R in LPS induced L6 cells, the expression of AchR was up-regulated significantly. But there was not difference of contractile proteins.Conclusions Protein 4.1R was upregulated in diaphragmatic weakness model in vivo and in vitro and might be involved into the occurrence of myasthenia gravis by negatively regulating the expression of AchR.
Dental Health and Dental Care Utilization Among Able-Bodied Adults on Medicaid in Kentucky After Medicaid Expansion: A Mixed Methods Study
Authors: Wang Tim T , Dixon Erica L. , Bair Elizabeth F , Ferrell William , Linn Kristin A. , Volpp Kevin G. , Underhill Kristen , Venkataramani Atheendar S. 
Published: December 2019

Abstract
Background. Dental utilization remains low among adults on Medicaid, despite the ACA expansion increasing access to care in many states. It remains unclear whether low utilization reflects low demand or other barriers. Our objective was to examine factors associated with poor perceived dental health and low dental utilization among adults on Medicaid. Methods. We conducted a large survey of able-bodied adults (N=9,363) on Medicaid in Kentucky from between May and September 2018, which included questions on perceived dental health and utilization of dental care. Semi-structured interviews were also conducted with a subset of participants (N=127) from May to November 2018. Results. 37.8% of respondents reported fair or poor oral health, higher than the 26.2% with fair or poor physical health. 47.6% indicated needing dental care in the last six months, but only half of this group reported receiving all the care they needed. Both low demand and a number of barriers, including lack of coverage for needed services and lack of access to care (low provider availability, transportation difficulties), appeared to explain low rates of utilization. Conclusions. Low dental utilization reflects a combination of low demand and barriers to care. Coverage and access issues could be mitigated by expanding the range of covered services and increasing provider availability.
Factors affecting community based health insurance utilization in Ethiopia: A systematic review
Authors: Bayked Ewunetie Mekashaw , Kahissay Mesfin Haile , Workneh Birhanu Demeke 
Published: December 2019

Abstract
Background: The goal of health care financing in Ethiopia has been to achieve universal health care coverage by minimizing the catastrophic out of pocket health service expenditure. Even though the performance was not as planned, the promising strategy to achieve universal health care coverage in the informal sector was community based health insurance which was expected to cover more than 83 % of the population. So, we systematically reviewed determinants of community based health insurance utilization in Ethiopia. Methods: We searched DOAJ, EconBiz, ERIC, Google Scholar, Oxford Journals, PubMed, SpringerLink, Europe PMC, Microsoft Academic Search, OAIster and AJ including various relevant websites by March 9 to 10, 2019. We included articles regardless of their publication status with both quantitative and qualitative approaches. Results: The factors determining community based health insurance utilization in Ethiopia were found to be associated with supply side, health facility, demographic and socioeconomic predictors. Among demographic and socio-economic factors, the report of the studies regarding to gender and age was not consistent. However income, education, community participation, marriage, occupation and family size were found to be significant predictors and were positively related with the scheme’s utilization. With respect to health status and health service related factors; illness experience, benefit package, awareness level, previous out of pocket expenditure for health care service and health service status (quality, adequacy, efficiency and coverage) were significantly and positively related but premium amount, self-rated health status and bureaucratic complexity were found to be negative predictors. Conclusion: To achieve universal health care coverage through community based health insurance, it is advisable that special attention should be given to income level, education, community participation, marriage, family size, benefit package, awareness level and health service quality, premium amount and bureaucratic or governance issue.