bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Patients With Meningiomas
Authors: Kuranari Yuki , Tamura Ryota , Tsuda Noboru , Kosugi Kenzo , Morimoto Yukina , Yoshida Kazunari , Toda Masahiro 
Published: November 2020

BackgroundMeningiomas are the most common benign intracranial tumors. However, even WHO grade I meningiomas occasionally show local tumor recurrence. Prognostic factors for meningiomas have not been fully established. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic factor for several solid tumors. The prognostic value of NLR in meningiomas has been analyzed in few studies.Materials and MethodsThis retrospective study included 160 patients who underwent surgery for meningiomas between October 2010 and September 2017. We analyzed the associations between patients’ clinical data (sex, age, primary/recurrent, WHO grade, extent of removal, tumor location, peritumoral brain edema, and preoperative laboratory data) and clinical outcomes, including recurrence and progression-free survival (PFS).ResultsForty-four meningiomas recurred within the follow-up period of 3.8 years. WHO grade II, III, subtotal removal, history of recurrence, Ki-67 labeling index ≥3.0, and preoperative NLR value ≥2.6 were significantly associated with shorter PFS (P &lt; 0.001, &lt; 0.001, 0.002, &lt; 0.001, and 0.015, respectively). Furthermore, NLR ≥ 2.6 was also significantly associated with shorter PFS in a subgroup analysis of WHO grade I meningiomas (P = 0.003). In univariate and multivariate analyses, NLR ≥2.6 remained as a significant predictive factor for shorter PFS in patients with meningioma (P = 0.014).ConclusionsNLR may be a cost-effective and novel preoperatively usable biomarker in patients with meningiomas.
Initial Gamma Knife Radiosurgery for Large or Documented Growth Asymptomatic Meningiomas: Long-Term Results From a 27-Year Experience
Authors: Fu Junyi , Wu Lisha , Peng Chao , Yang Xin , You Hongji , Cao Linhui , Deng Yinhui , Yu Jinxiu 
Published: November 2020

ObjectiveThe aims of this study were to investigate the long-term outcomes of initial Gamma Knife radiosurgery (GKRS) for large (≥20 mm) or documented growth asymptomatic meningiomas.Design and MethodsThis was a single-center retrospective study. Fifty-nine patients with large (≥20 mm) or documented growth asymptomatic meningiomas undergoing initial GKRS were enrolled. The median age was 56 (range, 27–83) years. The median time of follow-up was 66.8 (range, 24.6–245.6) months, and the median tumor margin dose was 13.0 Gy (range, 11.6–22.0 Gy).ResultsTumors shrunk in 35 patients (59.3%) and remained stable in 23 (39.0%). One patient (1.7%) experienced radiological progression at 54 months after GKRS. The PFS was 100%, 97%, and 97% at 3, 5, and 10 years, respectively. Nine patients (15.3%) occurred new neurological symptoms or signs at a median time of 8.1 (range, 3.0–81.6) months. The symptom PFS was 90% and 78% at 5 and 10 years, respectively. Fifteen patients (25.4%) occurred peritumoral edema (PTE) at a median time of 7.2 (range, 2.0–81.6) months. One patient underwent surgical resection for severe PTE. In univariate and multivariate analysis, Only tumor size (≥25 mm) and maximum dose (≥34 Gy) were significantly associated with PTE [hazard ratio (HR)= 3.461, 95% confidence interval (CI)=1.157-10.356, p=0.026 and HR=3.067, 95% CI=1.068-8.809, P=0.037, respectively].ConclusionsIn this study, initial GKRS can provide a high tumor control rate as well as an acceptable rate of complications in large or documented growth asymptomatic meningiomas. GKRS may be an alternative initial treatment for asymptomatic meningiomas.
Comprehensive Transcriptomic Analysis Reveals Dysregulated Competing Endogenous RNA Network in Endocrine Resistant Breast Cancer Cells
Authors: Gao Liang , Shen Kunwei , Yin Ni , Jiang Min 
Published: November 2020

BackgroundTamoxifen and fulvestrant, both approved for endocrine therapy, have remarkably increased the prognosis of hormone receptor-positive breast cancer patients. However, acquired resistance to endocrine therapy greatly reduces its clinical efficacy. Accumulating evidence suggests a pivotal role of non-coding RNAs (ncRNAs) in breast cancer endocrine resistance, but the specific functions of ncRNAs in tamoxifen and fulvestrant resistance remain largely unknown.MethodsMicroarray analysis was performed for endocrine therapy sensitive (MCF-7), tamoxifen-resistant (LCC2), and dual tamoxifen and fulvestrant-resistant (LCC9) breast cancer cells. Gene ontology and pathway analysis were conducted for functional prediction of the unannotated differentially expressed ncRNAs. Competing endogenous RNA regulatory networks were constructed.ResultsWe discovered a total of 3,129 long non-coding RNAs (lncRNAs), 13,556 circular RNAs (circRNAs), 132 microRNAs, and 3358 mRNAs that were significantly differentially expressed. We constructed co-expression networks for lncRNA-mRNA, circRNA-mRNA, and microRNA-mRNA. In addition, we established lncRNA-microRNA-mRNA and circRNA-microRNA-mRNA regulatory networks to depict ncRNA crosstalk and transcriptomic regulation of endocrine resistance.ConclusionsOur study delineates a comprehensive profiling of ncRNAs in tamoxifen and fulvestrant resistant breast cancer cells, which enriches our understanding of endocrine resistance and sheds new light on identifying novel endocrine resistance biomarkers and potential therapeutic targets to overcome endocrine resistance.
Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains
Authors: Erukainure Ochuko L. , Matsabisa Motlalepula G. , Salau Veronica F. , Islam Md. Shahidul 
Published: November 2020

Reduced brain glucose consumption arising from impaired glucose uptake and utilization has been linked to the pathogenesis and complications of neurodegenerative diseases. The ability of Cannabis sativa L. tetrahydrocannabinol (THC)-rich extracts to stimulate brain glucose uptake and utilization as well as its modulatory effect on gluconeogenesis, antioxidative, purinergic and cholinergic activities were investigated in isolated rats’ brains. C. sativa leaves were sequentially extracted to yield the hexane and dichloromethane extracts. The extracts were incubated at 37°C with freshly harvested brains in the presence of glucose for 2 h. The control consisted of incubation without the extracts, while brains without the extracts and glucose served as the normal control. Metformin was used as the standard drug. C. sativa extracts caused a significant (p &lt; 0.05) increase in brain glucose uptake, with concomitant elevation of glutathione level, superoxide dismutase, catalase, and ecto-nucleoside triphosphate diphosphohydrolase activities compared to the controls. Incubation with C. sativa extracts also led to depletion in malondialdehyde and nitric oxide levels, acetylcholinesterase, butyrylcholinesterase, glucose 6-phosphatase and fructose-1,6-biphosphatase activities. GC-MS analysis of the extracts revealed the presence of THC. In silico analysis predicted THC to be permeable across the blood-brain-barrier. THC was also predicted to have an oral LD50 and toxicity class values of 482 mg/kg and 4 respectively. These results indicate that C. sativa improves glucose consumption with concomitant suppression of oxidative stress and cholinergic dysfunction, and modulation of purinergic and gluconeogenic activities in brain tissues
Can We Apply WHOQOL-AGE to Asian Population? Verifying Its Factor Structure and Psychometric Properties in a Convenience Sample From Taiwan
Authors: Lin Chung-Ying , Wang Jung-Der , Liu Li-Fan 
Published: November 2020

Objectives: To translate and validate a recently developed quality of life instrument (WHOQOL-AGE) on geriatric population into Chinese.Method: Using cross-sectional observational design, the WHOQOL-AGE was conducted among older people through interview. Confirmatory factor analysis (CFA) was used to examine the factor structure and multigroup CFA used to examine the measurement invariance.Results: Through convenience sampling, 522 older adults (mean age = 73.42) participated in the study. Among them, 194 were males, 213 had an educational level at primary school or below, 398 were residing in the community, and 307 were aged 70 years or above. A bifactor structure (items Q1–Q8 are embedded in the factor 1; items Q9–Q13 embedded in the factor 2; and all the items embedded in an additional construct of QoL) was confirmed by the CFA in both the entire sample (χ2 = 25.4; df = 51; p = 0.999) and the subgroup sample with age 70 years or above (χ2 = 25.28; df = 51; p = 1.000). Multigroup CFAs results supported the measurement invariance for the WHOQOL-AGE across genders, having different educational levels, living in different settings and age groups. It also shows good known-groups validity.Conclusions: The promising psychometric properties of the WHOQOL-AGE were found in our convenience sample of older Taiwanese. The supported measurement invariance indicates that the older people in different conditions of gender, educational level, and living setting interpret the WHOQOL-AGE similarly. However, our results should be interpreted with cautious because of the sample representativeness.
Esophageal Rhabdoid-Like Tumor: A Rare Disease With Aggressive Clinical Behavior
Authors: Lovece Andrea , Bernardi Daniele , Bruni Barbara , Asti Emanuele , Clemente Claudio , Bonavina Luigi 
Published: November 2020

Background: Malignant rhabdoid tumor is a kidney childhood tumor with aggressive clinical behavior and a wide spectrum of histologic, immunophenotypic, and cytogenetic findings. Extra-renal rhabdoid tumors have been reported in the brain, breast, liver, pancreas, bladder, vulva, prostate, and colon. To date, only nine cases of esophageal rhabdoid tumors have been described, all in patients over 50-year old. We add to the current literature the case of an esophageal, poorly differentiated rhabdoid tumor occurring in a young man.Case Report: A 24-year-old man was referred for progressive dysphagia, retrosternal pain, nausea, and food regurgitation. Esophagogastroduodenoscopy showed an obstructing neoplastic lesion of the distal esophagus associated with Barrett's esophagus. Biopsies revealed undifferentiated esophageal cancer with epithelial morphology and immunohistochemistry positive for CK pan, CK 7 e CK 8-18. Minimally invasive esophagectomy and extended lymphadenectomy was performed. Histopathology showed a poorly differentiated tumor, with morphologic characteristics of rhabdoid tumor, central necrosis and transmural infiltration of the esophageal wall. Definitive immunohistochemistry was positive for vimentin, CD34, synaptophysin, and INI1.Conclusion: Esophageal rhabdoid tumor is extremely rare and highly aggressive, with only few patients alive at 1 year follow-up, according to our review. Immunohistochemistry characterization is critical for diagnosis. Minimally invasive esophagectomy is an appealing and possibly less morbid option compared to open surgery. However, further research is needed to investigate the potential role of targeted immunotherapy.
Maksim Kuantitas pada Ragam Kolokial dalam Sentra Pelayanan Publik
Authors: Nazihah Wafiqotin , Mujianto Gigit 
Published: November 2020

Artikel ini akan mendeskripsikan maksim kuantitas pada pemakaian kolokial dalam sentra pelayanan publik. Pendekatan yang digunakan dalam penelitian adalah pendekatan kualitatif. Data dalam penelitian berupa penggunaan maksim kuantitas pada pemakaian kolokial sesuai dengan tingkatan yang sesuai dalam sebuah interaksi. Sumber data dalam penelitian adalah dua contoh video pelayanan publik yang diperoleh dari situs youtube. Pengumpulan data dilakukan dengan teknik simak catat. Teknik analisis data menggunakan teori Miles dan Huberman dan menggunakan alur pengumpulan data, reduksi data dan penarikan kesimpulan secara tuntas. Hasil penelitian menunjukkan representasi maksim kuantitas pada pemakaian kolokial dalam sentra pelayanan publik mengarah pada (1) penggunaan kata dasar. (2) penggunaan vokal dalam sebuah kata. (3) penggunaan suku kata terakhir sebuah kata. dan (4) penggunaan konsonan dalam sebuah kata.Katakunci: kolokial, kuantitas, maksim, pelayananAbstract:This article will describe the maxim of quantity of colloquial use in public service centers. The approach used in this research is a qualitative approach. The data in this research is the use of maxim of quantity in colloquial use based on the appropriate level in an interaction. Sources of data in the study are two examples of public service videos obtained from the YouTube site. Data collection was conducted by using note-taking technique. The data analysis technique used the theory of Miles and Huberman and the flow of data collection, data reduction and conclusion. The results show that the representation of maxim of quantity in colloquial use in public service centers leads to (1) the use of basic words. (2) the use of vowels in a word. (3) the use of the last syllable of a word and (4) the use of consonants in a wordKeywords: colloquial, maxims, quantity, service
Penggunaan Model "Picture and Picture" dalam Pembelajaran Menulis Teks Prosedur
Authors: Handriani Yessi , Nur Dini , Maryam Siti 
Published: November 2020

Artikel ini penggunaan model pembelajaran “Picture and Picture” dalam pembelajaran menulis teks prosedur. Metode yang digunakan ialah metode eksperimen dengan rancangan “one group pretest-posttest design”. Sampel yang terpilih adalah kelas VII A SMP Terpadu Miftahul Ulum. Teknik pengumpulan data yang digunakan adalah penggunaan lembar tes, penggunaan lembar angket atau kuesioner, penggunaan pedoman observasi, dan penggunaan pedoman wawancara. Hasil penelitian ini menunjukkan 1) kemampuan menulis teks prosedur mengalami peningkatan dilihat dari perolehan nilai peserta didik dengan selisih 14 angka, 2) hasil uji prasyarat pengolahan data memperoleh nilai signifikansi sebesar 0,000 < 0,05 sehingga dapat disimpulkan bahwa model membelajaran “Picture and Picture” dapat digunakan dalam pembelajaran teks prosedur, 3) model pembelajaran “Picture and Picture” dapat mempermudah pembelajaran menulis teks prosedur, dan 4) model pembelajaran “Picture and Picture” efektif digunakan dalam pembelajaran menulis teks prosedur. Kata kunci: Menulis, teks prosedur, picture and picture..Abstract:This article discusses the use the "Picture and Picture" learning model in learning to write procedural texts. The method used an experimental method with a "one group pretest-posttest design". The sample was class VII A SMP Terpadu Miftahul Ulum. The data collection techniques utilized test sheets, questionnaire sheets, observation guidelines, and interview guidelines. The results of this study indicate that 1) the ability to write procedural text has increased as seen from students' scores with 14 points increase 2) the results of the data processing of prerequisite test obtained a significance value of 0.000 <0.05 so it can be concluded that "Picture and Picture" learning model can be used in learning procedure text, 3) the "Picture and Picture" learning model can make it easier to learn to write procedure text, and 4) the "Picture and Picture" learning model is effective to use in learning to write procedure text.Keywords: writing, procedural text, picture and picture
Kritik Sosial dalam Novel "Anak-Anak Tukang" Karya Baby Ahnan
Authors: Nisak Khoirun , Anggraini Purwati 
Published: November 2020

Artikel ini mendiskusikan kritik sosial dalam novel “Anak-Anak Tukang” karya Baby Ahnan. Novel itu mengisahkan hiruk piruk kehidupan lingkungan sosial yang di dalamnya mengandung kritik sosial seperti soal pemerataan pembangunan pendidikan. Sementara pengertian kritik pada dasarnya merupakan wujud sambutan pembaca yang menghakimi serta menilai karya sastra guna memberi penilaian dan memberi keputusan baik dan buruk tidaknya suatu karya satra yang telah dibaca oleh kritikus. Metode yang digunakan metode deskriptif kualitatif dan pendekatan sosiologi sastra. Hasil penelitian menunjukkan bahwa pembangunan fisik yang terjadi di daerah seperti Flores ternyata tidak menjamin terjadinya peningkatan kesejatraan masyarakat. Kemudian, pemanfaatan tenaga kerja lokal di sektor pembangunan menjadi tidak optimal karena pendidikan mereka rendah sebagai akibat pendidikan yang tidak merata.Katakunci: kritik, sosial, lingkungan, pendidikan Abstract:This article discusses social criticism in Baby Ahnan's novel “Anak-Anak Tukang”. The novel tells a story of the hustle and bustle of social life which contains social criticism, such as the issue of equality of education. Meanwhile, the definition of criticism is basically a form of response from readers who judge and judge literary works in order to give judgments and make decisions about whether or not a literary work has been read by critics. The method used was descriptive qualitative method and sociological literary approach. The results show that physical infrastructure development in areas such as Flores did not guarantee an improvement in the welfare of the community. Then, the utilization of local labor in the development sector is not optimal because their education is low as a result of unequal education.Keywords: criticism, education, environmental, social
DONANTE VIVO HEPÁTICO ADULTO-PEDIÁTRICO TOTALMENTE LAPAROSCÓPICO. ASPECTOS TÉCNICOS Y RESULTADOS.
Authors: Troncoso T. Andres , Sanhueza G. Marcel , Rodriguez G. Javier , Pattilo S. Juan Carlos , Briceño V. Eduardo , Guerra C. Juan Francisco , Martínez C. Jorge , Dib M. Martín , Jarufe C. Nicolás 
Published: November 2020

Introducción: La cirugía hepática laparoscópica ha presentado un desarrollo más lento debido a la complejidad que ésta posee, lo que determina una curva de aprendizaje prolongada. En relación a la hepatectomía laparoscópica para donante vivo en trasplante hepático (TH), ésta se ha retrasado aún más por las preocupaciones sobre la seguridad del donante, el resultado del injerto y la adquisición de las competencias técnicas de los cirujanos. El objetivo de este artículo, es exponer detalles técnicos de la hepatectomía izquierda laparoscópica de donantes vivos adultos para trasplante pediátrico y se presentan los resultados quirúrgicos de los casos realizados en este centro.Materiales y Métodos: Presentación de la técnica quirúrgica de la hepatectomía izquierda en donantes vivos para TH en receptores pediátricos además de realizar un estudio cohorte no concurrente de pacientes sometidos a esta cirugía en el Hospital Clínico de la Universidad Católica entre mayo de 2011 y noviembre de 2017.Resultados: La serie consta de 15 pacientes, 60% sexo femenino. Trece pacientes (86,6%) eran madre o padre del receptor. El 100% de pacientes fue sometido a hepatectomía izquierda laparoscópica sin necesidad de conversión. Morbilidad Clavien–Dindo > 3, 1 paciente requirió punción percutánea de bilioma. Mediana de hospitalización de 3 días (2-5). No hubo mortalidad.Conclusión: La hepatectomía izquierda por vía laparoscópica de donante vivo para TH pediátrico es un procedimiento seguro y factible de realizar en este centro, con excelentes resultados en términos de morbimortalidad y consideramos que esta técnica debe ser la vía de elección para donantes vivos adultos-pediátricos.
Cáncer de nasofaringe
Authors: Taissoun Aslan Zaki Antonio , Moreno Tobón Andrea , Árevalo Novoa Joel , Rojas Gutierrez Andrés Felipe , Giraldo Rendón Lina Marcela , Restrepo Carlos Anibal 
Published: November 2020

Introducción: El cáncer de nasofaringe es una patología poco común que tiene gran impacto en la calidad de vida de los pacientes. Con el advenimiento de nuevos esquemas de tratamiento se ha logrado mejorar el pronóstico con un menor índice de morbilidad. Esta revisión describe la perspectiva actual del cáncer de nasofaringe, basado en la literatura reciente y la disponibilidad de recursos para su tratamiento en una institución médica de Medellín, Colombia.Materiales y Métodos: Se realizó una búsqueda bibliográfica que incluyó artículos desde 1986 hasta 2018 en diferentes bases de datos como MEDLINE, EBSCO y LILACS. Se incluyó literatura escrita en inglés o español, utilizando como términos MESH Neoplasias de nasofaringe, diagnóstico y terapéutica.Resultados: La evaluación diagnóstica oportuna del cáncer de nasofaringe es de vital importancia al proporcionar una estrategia de tratamiento efectiva con menor morbimortalidad. Según la experiencia institucional de los autores, en las etapas clínicas tempranas se sugiere la radioterapia radical como modalidad única y en etapas intermedias- avanzadas los tratamientos combinados con quimioterapia–radioterapia concomitante o secuencial dependiendo de cada paciente y quimioterapia única en pacientes metastásicos a distancia. Conclusiones: Acorde con el análisis de la literatura y evidencia existente, las estrategias utilizadas son adaptadas a los alcances de la institución como ente de alto nivel en el sector salud. La cirugía representa un papel relevante en la enfermedad recurrente resecable ya sea con técnica endoscópica o abierta. Es importante recordar que la morbilidad postoperatoria no es inocua, y en ocasiones sobrepasa el beneficio obtenido.
A diáspora haitiana, a noção de hos(ti)pitalidade e a busca do lugar sob o olhar geográfico
Authors: Jn Charles Charlot , Aparecida Ianesko Renata , Da Costa Silva Josué 
Published: November 2020

Este artigo busca compreender a situação da diáspora haitiana no contexto brasileiro, especificamente, na cidade de Porto Velho - RO. Para tanto, utilizamos a metodologia da “História Oral” de Meihy (2005), a perspectiva desconstrutivista e noções de hos(ti)pitalidade de Derrida (2003). Os objetivos do trabalho são: a) entender a situação da diáspora haitiana nesse contexto atual; b) observar se os haitianos entrevistados se consideram incluídos no espaço amazônico em que vivem, especialmente, na sociedade portovelhense e c) compreender como se manifestam as noções de hos(ti)pitalidade na vida do imigrante. Para as reflexões foram entrevistados haitianos que moram no Brasil no período entre 2011 a 2019. Como resultado observamos que devido a COVID-19 o público pesquisado vive uma incerteza sobre o futuro, no entanto, ecoam efeitos de sentido de que ainda há esperança de conseguirem realizar seus sonhos. Apreendemos que os entrevistados, em geral, se sentem incluídos no espaço amazônico e pertencentes a esse espaço, mesmo com todas as dificuldades encontradas. Percebemos, também, que os haitianos vivem entre a hospitalidade e a hostilidade, portanto, a noção de hos(ti)pitalidade está em constante multiplicidade de sentidos no discurso dos entrevistados.