bluuebunny/crossref_metadata_2025_split huggingface dataset:
Power Domination Number On Shackle Operation with Points as Lingkage
Authors: Saifudin Ilham 
Published: May 2020

The Power dominating set is a minimum point of determination in a graph that can dominate the connected dots around it, with a minimum domination point. The smallest cardinality of a power dominating set is called a power domination number with the notation . The purpose of this study is to determine the Shackle operations graph value from several special graphs with a point as a link. The result operation graphs are: Shackle operation graph from Path graph , Shackle operation graph from Sikel graph , Shackle operation graph from Star graph . The method used in this paper is axiomatic deductive method in solving problems. Understanding the axiomatic method itself is a method of deductive proof principles that applies in mathematical logic by using theorems that already exist in solving a problem. In this paper begins by determining the paper object that is the Shackle point operations result graph. Next, determine the cardinality of these graphs. After that, determine the point that has the maximum degree on the graph as the dominator point of power domination. Then, check whether the nearest neighbor has two or more degrees and analyze its optimization by using a ceiling function comparison between zero forching with the greatest degree of graph. Thus it can be determined ϒp minimal and dominated. The results of the power domination number study on Shackle operation graph result with points as connectors are , for and ; , for and ; , for and .
ANALISIS PENYELESAIAN SENGKETA HARTA BERSAMA AKIBAT PUTUSAN PERKAWAINAN KARENA KEMATIAN
Authors: Effendi Devi Rianti 
Published: May 2020

Sebagai sarana perlindungan, dijadikan sebagai kedok untuk memperoleh keuntungan atau demi kepentingan sepihak dan memandang tidak lagi sebagai subjek yang harus dilindungi kepentingannya menjadi sebuah objek diam yang lemah. Untuk itulah diperlukan penanganan yang serius agar masalah ini tidak dijadikan kesempatan bagi pihak-pihak yang mencari keuntungan sendiri, maka dalam hal pembagian harta bersama akibat kematian sangat menarik untuk dikaji. Dari latar belakang diatas maka penulis tertarik mengangkat masalah penyelesaian sengketa harta bersama akibat putusnya perkawinan karena kematian. Adapun ruang lingkup atau rumusan masalah yang dimaksud adalah sebagai berikut, Pertama, Bagaimana penyelesaian sengketa harta bersama akibat putusnya perkawinan karena kematian, Kedua, Upaya penyelesaian sengketa harta bersama akibat putusnya perkawinan karena kematian. Dari rumusan masalah ini maka metode penulisan ini adalah Yaitu dengan jalan membaca bahan-bahan tulisan ilmiah, buku-buku literatur, Peraturan-peraturan Perundang-undangan dan berbagai konsep lainnya yang dipandang dapat menambah kejelasan permasalahan dan arah pembahasan yang ada relevan dalam Penulisan. Dan Comperastive Study yaitu dengan cara membaca dan membanding-bandingkan berbagai teori yang ada untuk mendapatkan kesimpulan yang dapat dijadikan bahan dalam penyusunan ini. Dalam penulisan ini teknik analisa data yang digunakan adalah analisa data secara kuantitatif, yaitu memberikan pembahasan atau suatu penjelasan tentang bahan Penulisan yang datanya mengarah pada kajian yang bersifat teoritis mengenai konsep-konsep dan berbagai bahan hukum lainnya, yaitu dimana pernyataan khusus dikaitkan dengan pernyataan umum yang diperoleh dilapangan. Jadi janganlah kita mengucilkan janda. Janda juga ingin didengar dan diayomi bukan menjadi bahan pergunjingan, apalagi jika janda itu, menyembuhkan psikis sangatlah berat bagi seorang janda. Mencoba menutup telinga demi dan menguatkan dari gunjingan orang lain. Janda itu tidak selamanya jelek, tidak selamanya mengganggu hubungan orang, tidak selamanya dia hina. Janda bisa berkarya, bisa menciptakan lapangan pekerjaan dan bisa menjaga perilakunya. Jadi terima kami, hargai kami karena kami juga bisa menjadi orang yang bermanfaat dan membanggakan untuk kalian.
Multi-National, Cross-Sectional Survey of Healthcare Resource Utilization in Patients with All Stages of Cognitive Impairment, Analyzed by Disease Severity, Country, and Geographical Region
Authors: Khandker Rezaul K. , Ritchie Craig W. , Black Christopher M. , Wood Robert , Jones Eddie , Hu Xiaohan , Ambegaonkar Baishali M. 
Published: May 2020

Background: Alzheimer’s disease (AD) is one of the most disabling conditions worldwide and the disease burden increases with the aging global population. There are only a few prospective studies using real-world data to support effective healthcare resource utilization (HCRU) in AD. Objective: To confirm the association between HCRU and AD severity in a real-world population, including patients with all cognitive impairment (CI) severities. Methods: Data were drawn from a multi-national, cross-sectional survey of physicians and their consulted patients with all stages (very mild, mild, moderate, and severe) of CI including AD conducted in France, Germany, Italy, Spain, UK, US, and Canada. Elements of HCRU including medical consultations, professional caregiver hours, hospitalization, and institutionalization were compared between CI severity subgroups, and by country and region. Results: 6,143 CI patients were included with very mild ( n = 659), mild ( n = 2,473), moderate ( n = 2,603), and severe ( n = 408) dementia. HCRU increased with increasing CI severity ( p < 0.001) for the majority of elements measured. Further analyses of overall and regional populations also confirmed significant increases in most HCRU elements with increasing disease severity. The general trend toward increased HCRU with increased CI severity was also seen in individual countries. Individual country data appeared to indicate that earlier intervention decreased hospitalizations and full-time institutionalization at the later (more severe) disease stages. Conclusion: Our findings confirmed that HCRU increases with increasing CI severity. Effective intervention in early disease could therefore reduce or delay incurring greater HCRU costs associated with more severe disease. Further studies are needed to confirm this hypothesis.
Effects of LDL Cholesterol and Statin Use on Verbal Learning and Memory in Older Adults at Genetic Risk for Alzheimer’s Disease
Authors: Wroolie Tonita , Roat-Shumway Siena , Watson Katie , Reiman Eric , Rasgon Natalie 
Published: May 2020

Background: The apolipoprotein epsilon 4 ( APOE4) allele is a well-established genetic risk factor for Alzheimer’s disease (AD). However, there are mixed findings as to how the APOE4 allele modifies the effects of both higher low-density lipoprotein cholesterol (LDL) and statin use on cognitive functioning. Objective: This study sought to examine the effects of LDL levels and statin use on verbal learning and memory, as modified by the presence of the APOE4 allele, in a sample of cognitively unimpaired, older adults at risk for AD. Methods: Neuropsychological, LDL, statin use, and APOE4 data were extracted from an ongoing longitudinal study at the Banner Alzheimer’s Institute in Arizona. Participants were cognitively unimpaired based on Mini-Mental State Examination scores within a normal range, aged 47–75, with a family history of probable AD in at least one first-degree relative. Results: In the whole sample, higher LDL was associated with worse immediate verbal memory in APOE4 non-carriers, but did not have an effect on immediate verbal memory in APOE4 carriers. In APOE4 non-carriers, statin use was associated with better verbal learning, but did not have an effect on verbal learning in APOE4 carriers. Among women, higher LDL in APOE4 carriers was associated with worse verbal learning than in APOE4 non-carriers, and statin use in APOE4 non-carriers was associated with better verbal learning and immediate and delayed verbal memory but worse performances on these tasks in APOE4 carriers. Conclusion: LDL and statin use may have differential effects on verbal learning and/or memory depending on genetic risk for AD. Women appear to be particularly vulnerable to statin use depending on their APOE4 status.
Cognition and the Predictive Utility of Three Risk Scores in an Ethnically Diverse Sample
Authors: Torres Stephanie , Alexander Angel , O’Bryant Sid , Medina Luis D. 
Published: May 2020

Background: Various factors, such as age, cardiovascular concerns, and lifestyle patterns, are associated with risk for cognitive decline and Alzheimer’s disease (AD). Risk scores model predictive risk of developing a disease (e.g., dementia, stroke). Many of these scores have been primarily developed in largely non-Hispanic/Latino (non-H/L) White samples and little is known about their applicability in ethno-racially diverse populations. Objective: The primary aim was to examine the relationship between three established risk scores and cognitive performance. These relationships were compared across ethnic groups. Methods: We conducted a cross-sectional study with a multi-ethnic, rural-dwelling group of participants ( Mage = 61.6±12.6 years, range: 40–96 years; 373F:168M; 39.7% H/L). The Cardiovascular Risk Factors, Aging and Dementia (CAIDE), Framingham Risk Score (FRS), and Washington Heights-Inwood Columbia Aging Project (WHICAP) score were calculated for each participant. Results: All three scores were significantly associated with cognition in both H/L and non-H/L groups. In H/Ls, cognition was predicted by FRS: β= –0.08, p = 0.022; CAIDE: β= –0.08, p < 0.001; and WHICAP: β= –0.04, p < 0.001. In non-H/Ls, cognition was predicted by FRS: β= –0.11, p < 0.001; CAIDE: β= –0.14, p < 0.001; and WHICAP: β= –0.08, p < 0.001. The strength of this relationship differed between groups for FRS [t(246) = –4.61, p < 0.001] and CAIDE [t(420) = –3.20, p = 0.001], but not for WHICAP [t(384) = –1.03, p = 0.30], which already includes ethnicity in its calculation. Conclusion: These findings support the utility of these three risk scores in predicting cognition while underscoring the need to account for ethnicity. Moreover, our results highlight the importance of cardiovascular and other demographic factors in predicting cognitive outcomes.
Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains
Authors: Haditsch Ursula , Roth Theresa , Rodriguez Leo , Hancock Sandy , Cecere Thomas , Nguyen Mai , Arastu-Kapur Shirin , Broce Sean , Raha Debasish , Lynch Casey C. , Holsinger Leslie J. , Dominy Stephen S. , Ermini Florian 
Published: May 2020

Background: Porphyromonas gingivalis ( P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer’s disease (AD). In a recent study we demonstrated the presence of gingipains in over 90% of postmortem AD brains, with gingipains localizing to the cytoplasm of neurons. However, infection of neurons by P. gingivalis has not been previously reported. Objective: To demonstrate intraneuronal P. gingivalis and gingipain expression in vitro after infecting neurons derived from human inducible pluripotent stem cells (iPSC) with P. gingivalis for 24, 48, and 72 h. Methods: Infection was characterized by transmission electron microscopy, confocal microscopy, and bacterial colony forming unit assays. Gingipain expression was monitored by immunofluorescence and RT-qPCR, and protease activity monitored with activity-based probes. Neurodegenerative endpoints were assessed by immunofluorescence, western blot, and ELISA. Results: Neurons survived the initial infection and showed time dependent, infection induced cell death. P. gingivalis was found free in the cytoplasm or in lysosomes. Infected neurons displayed an accumulation of autophagic vacuoles and multivesicular bodies. Tau protein was strongly degraded, and phosphorylation increased at T231. Over time, the density of presynaptic boutons was decreased. Conclusion: P. gingivalis can invade and persist in mature neurons. Infected neurons display signs of AD-like neuropathology including the accumulation of autophagic vacuoles and multivesicular bodies, cytoskeleton disruption, an increase in phospho-tau/tau ratio, and synapse loss. Infection of iPSC-derived mature neurons by P. gingivalis provides a novel model system to study the cellular mechanisms leading to AD and to investigate the potential of new therapeutic approaches.
THE USE OF ANAGRAMS TO INCREASE STUDENTS’ ENGLISH VOCABULARY MASTERY
Authors: Prawiyata Yugi Diraga 
Published: May 2020

The objective of the research was to find out whether Anagrams increased students’ vocabulary mastery and to find out how was the students’ mastery in learning vocabulary by using Anagrams. The subject of this research was the second year students of MTs Al Washliyah 32 Sei Bamban in academic year 2018/2019 which consisted of thirty people. In this research, it was applied the Classroom Action Research (CAR). Technique of collecting the data was to use a written test, in a certain topic applied in Anagram technique where the researcher made the indicators as the test consisted of twenty where each number amounts to 5. Then the researcher observed the students’ action while the use of Anagram technique was implemented and also the students’ opinion about the effectiveness of Anagram technique toward their vocabulary mastery. The result of the research showed that the students’ score in the second cycle was higher (85-95) than the first cycle (68-90). In other words it indicated that the use of Anagrams really increase students’ vocabulary mastery.
PERAN LEMAK EPIKARDIAL PADA PENYAKIT JANTUNG KORONER STABIL
Authors: Fajar Ulzim , Yanni Mefri 
Published: May 2020

<p><em>Visceral fat tissue widely known have endocrine function by secreting Cytokines that provide it function in metabolism of visceral organ such as heart. It function have pivotal role under physiology and patology condition by secreting antiinflamatory cytokines in physiology condition, otherwise proinflammatory cytokines in patology condition. Epicardial fat tissue as regard this function, have more important role to the heart, because it have two advantage than other visceral depots. First, this tissue have same microcirculation provided by small branch of coronary arteries, and second it were not boundary by any structure. Recent studies found that there were correlation between increased epicardial fat depot and coronary artery disease. It seems correlate with this unique structure and function. This literature review focuse on how is the role of epicardial fat tissue in atheroschlerotic process especially in coronary artery.</em></p>
Reflexiones del desarrollo pedagógico socio-humanístico de estudiantes en proceso de formación docente de básica primaria.
Authors: Cifuentes Medina Jose Eriberto , Torres Ortiz Jaime Andres , Plazas Diaz Leidy Carolina 
Published: May 2020

El artículo pretende reflexionar sobre la importancia de los conocimientos socio-humanísticos en procura del rescate de la esencia de la academia, así como en la formación integral e idónea de estudiantes en proceso de formación docente de Educación Básica Primaria. El análisis parte de una revisión bibliográfica acerca de cuáles han sido las tendencias pedagógicas en el campo socio-humanístico que se han mantenido constantemente en las prácticas docentes, visibilizando allí dos vertientes del humanismo: uno clásico, neoconservador y romántico, el cual se basa en la formación por competencias, la práctica centrada en un currículo ya predefinido y las interacciones y relaciones que articulan contenidos tradicionales, los cuales están lejanos de las problemáticas latentes de las sociedades del conocimiento; y otro, poco frecuente, que se encamina hacia un humanismo liberador, emancipador y centrado en la libertad de los pueblos. Este último es el que nos interesa incentivar tanto en las aulas de clase universitaria en general, así como particularmente en el proceso de formación docente de estudiantes, con el fin de generar procesos democráticos y ciudadanos, así como espacios interculturales que permitan transformaciones de pensamiento necesarias para humanizar las sociedades de hoy.
KONSUMSI PISANG DAPAT MENURUNKAN TEKANAN DARAH PADA LANSIA
Authors: Zaima Zaima , Samino Samino , Mariza Ana , Kurniasari Devi 
Published: May 2020

ABSTRAK Latar Belakang Hipertensi atau tekanan darah tinggi adalah suatu kondisi ketika darah mengalir melalui pembuluh darah dengan kekuatan yang lebih besar dari biasanya. Penanganan yang dapat dilakukan selain terapi farmakologis adalah dengan mempergunakan terapi non farmakologi atau terapi komplementer. Salah satu tindakan pencegahan untuk menurunkan tekanan darah adalah dengan cara mengkonsumsi buah pisang. Tujuan penelitian adalah diketahui pengaruh konsumsi pisang terhadap penurunan tekanan darah pada lansia di Puskesmas Natar Kecamatan Natar Lampung Selatan 2019 Metode Jenis penelitian adalah kuantitatif dengan rancangan penelitian dengan pendekatan quasi eksperimen. Populasi dalam penelitian ini adalah seluruh lansia yang mengalami hipertensi dipuskesmas Natar Kecamatan Natar Lampung Selatan sebanyak 48 orang. Sampel 30 orang, Teknik sampling yang digunakan purposive sampling Pengumpulan data dengan menggunakan lembar observasi dan analisa data yang digunakan adalah uji t-dependent. Hasil penelitian didapatkan bahwa Distribusi frkuensi tekanan darah pada lansia sebelum mengkonsumsi pisang rata-rata 153 mmHg, standar deviasi 68. Namun setelah mengkonsumsi didapatkan ratarata 130 mmHg, standar deviasi 64 hasilnya beda mean 13,4, diperoleh nilai p value 0,001 yang artinya ada pengaruh konsumsi pisang terhadap penurunan tekanan darah padalansia. Kesimpulan: konsumsi pisang ambon sehingga menurunkan tekanan darah pada lansia. Saran bagi lansia dan masyarakat, bagi masyarakat maupun keluarga dapat menerapkan pengobatan herbal yang tepat untuk mengobati gejala hipertensi salah satunya mengkonsumsi pisang ambon agar menurunkan kadar tekanan darah tinggi, jadi bisa mengurangi penggunaan obat-obatan farmakologi yang ada efek sampingnya. Kata Kunci : Pisang Ambon, Hipertensi, LansiaI
PERBEDAAN KONSUMSI YOGURT MENGANDUNG POLYDEXTROSE DENGAN YOGURT TERHADAP KEJADIAN KONSTIPASI PADA IBU HAMIL
Authors: Auria Indri Lovely , Lathifah Neneng Siti , Maternity Dainty , Suharman Suharman 
Published: May 2020

ABSTRAK Latar Belakang Di Indonesia kasus konstipasi yang diderita oleh wanita hamil sekitar 4-30%, sedangkan konstipasi yang diderita masyarakat di atas usia lanjut sekitar 2-25% pada usia 60 tahun ke atas. Insiden konstipasi tersebut meningkat seiring dengan pertambahan umur dan penggunaan suplemen zat besi.Insiden konstipasi pada ibu hamil di Indonesia mencapai 15-20 % Tujuan dari penelitian ini adalah diketahui pengaruh konsumsi yogurt terhadap kejadian ibu hamil di BPM Fitri Hayati S.ST Bandar Lampung Tahun 2019. Metode Jenis penelitian kuantitatif, rancangan penelitian pendekatan quasi eksperimental deain dengan rancangan pretest-posttest with control group. sampel seluruh ibu hamil sebanyak 30 orang. 15 orang sebagai kelompok eksperimen dan 15 orang lainya sebagai kelompok control dengan teknik sampling purposive sampling. Analisa data dengan uji T-test independent. Hasil penelitian ini menunjukkan rata-rata frekuensi bab sesudah konsumsi yogurt yang mengandung polydextrose pada ibu hamil yang mengalami kontipasi di BPM Fitri Hayati S.ST Bandar Lampung Tahun 2019 yaitu 23.60 dan rata-rata frekuensi bab sebelum konsumsi yogurt pada ibu hamil yang mengalami kontipasi di BPM Fitri Hayati S.ST Bandar Lampung Tahun 2019 yaitu 19.20. Kesimpulan ada pengaruh pemberian konsumsi yogurt terhadap kejadian konstipasi pada ibu hamil di BPM Fitri Hayati S.ST Bandar Lampung Tahun 2019. Hasil uji t didapat p value 0,000 < α (0,05). Saran Dapat dijadikan sebagai metode nonfarmakologi untuk mengatasi kontipasi yang terjadi pada ibu hamil sengan mengkonsumsi Yogurt Polydextrose yang sangat efektif untuk menyembuhkan sembelit. Kata Kunci : Konsumsi Yogurt Polydextrose dan Yogurt,Kontipasi
MANFAAT BAYAM MERAH (AMARANTHUS GANGETICUS) UNTUK MENINGKATKAN KADAR HEMOGLOBIN PADA IBU HAMIL
Authors: Jaya Nilawati , Sary Lolita , Astriana Astriana , Putri Ratna Dewi 
Published: May 2020

ABSTRAK Latar belakang : Kejadian anemia pada kehamilan di Provinsi Lampung adalah tertinggi di pulau sumatera. Tingginya jumlah kasus anemia di Provinsi Lampung adalah sebesar 69,7%, angka tersebut lebih tinggi dari angka anemia gizi nasional yaitu sebesar 63%. Salah satu tumbuhan yang dapat menunjang kenaikan kadar hemoglobin adalah bayam merah karena bayam merah tinggi akan zat besi. Tujuan : Penelitian ini dilakukan untuk diketahui pengaruh konsumsi bayam merah (Amaranthus gangeticus) terhadap kenaikan kadar hemoglobin pada ibu hamil dengan anemia di PMB Hj. Amriyah, SST Kelurahan Daya Murni Kecamatan Tumijajar Kabupaten Tulang Bawang Barat Tahun 2019. Metode : Jenis penelitian kuantitatif, rancangan penelitian quasy eksperimen dengan pendekatan pretest posttest with control group. Populasi dalam penelitian ini adalah seluruh ibu hamil TM II dan III yang mengalami anemia sebanyak 43 ibu hamil. Sampel dalam penelitian ini adalah ibu hamil yang mengalami anemiapada saat dilakukan penelitian yaitu sebanyak 34 orang, 17 diberikan perlakuan dengan tablet FE dan jus bayam merah dan 17 diberikan perlakuan dengan tablet FE. Teknik sampling menggunakan purposive sampling. Analisa data dengan uji T-test independent. Hasil : Pada kelompok intervensi rata-rata kadar hemoglobin pretest sebesar 9,89 gr/dl dan posttest sebesar11,31 gr/dl. Sedangkan pada kelompok kontrol rata-rata kadar hemoglobin pretest sebesar 9,81 gr/dl dan posttest sebesar 10,73 gr/dl. Diketahui ada pengaruh konsumsi bayam merah (Amaranthus gangeticus) dan tablet FE terhadap kenaikan kadar hemoglobin pada ibu hamil dengan anemia di PMB Hj. Amriyah, SST Kelurahan Daya Murni Kecamatan Tumijajar Kabupaten Tulang Bawang Barat Tahun 2019. Hasil uji t-test didapat p value 0,000 < α (0,05). Simpulan : Pemberian kombinasi Bayam merah (amaranthus gangeticus) dan Tablet Fe meningkatkan rata-rata kadar hemoglobin pada ibu hamil di PMB Hj. Amriyah, SST Kecamatan Tumijajar Kabupaten Tulang Bawang Barat Tahun 2019 Saran: tenaga kesehatan khususnya bidan dan masyarakat, bahwa dengan mengkonsumsi jus bayam merah dan tablet fe dapat menaikan kadar hemoglobin pada ibu hamil dibandingkan hanya dengan mengkonsumsi tablet Fe saja Kata Kunci : Jus Bayam Merah, Hamil, Hemoglobin