bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of parity, sympathy and reciprocity in increasing social welfare
Authors: Sen Sandip , Crawford Chad , Dees Adam , Nanda Kumar Rachna , Hale James 
Published: June 2020

AbstractWe are interested in understanding how socially desirable traits like sympathy, reciprocity, and fairness can survive in environments that include aggressive and exploitative agents. Social scientists have long theorized about ingrained motivational factors as explanations for departures from self-seeking behaviors by human subjects. Some of these factors, namely reciprocity, have also been studied extensively in the context of agent systems as tools for promoting cooperation and improving social welfare in stable societies. In this paper, we evaluate how other factors like sympathy and parity can be used by agents to seek out cooperation possibilities while avoiding exploitation traps in more dynamic societies. We evaluate the relative effectiveness of agents influenced by different social considerations when they can change who they interact with in their environment using both an experimental framework and a predictive analysis. Such rewiring of social networks not only allows possibly vulnerable agents to avoid exploitation but also allows them to form gainful coalitions to leverage mutually beneficial cooperation, thereby significantly increasing social welfare.
Dying patients with COVID-19: What should Hospital Palliative Care Teams (HPCTs) be prepared for?
Authors: Anneser Johanna 
Published: June 2020

AbstractObjectiveThe COVID-19 pandemic is a care crisis of unknown duration which has seemingly not yet reached its peak in many countries. A significant number of elderly and frail people and those with underlying serious illness will continue to develop severe forms of the COVID-19 infection. Most of them are not eligible for intensive care treatment but can still expect palliative care — in many cases provided by a Hospital Palliative Care Team (HPCT). Several teams have already gained experience in caring for these patients and their families, others are preparing for it.MethodWe report on a COVID-19 patient with pre-existing acute myeloid leukemia who was looked after by a HPCT until death. We discuss the challenges and difficulties while caring for COVID-19-positive palliative patients in a non-ICU setting.ResultsHospitalization of the patient in an isolation ward caused an enormous burden for the dying patient and his family. Symptom control was particularly difficult because of rapid deteriorating dyspnea and the scarce presence of medical staff in the patient's room.Significance of resultsCOVID-19 patients who are not eligible for ICU treatment may have a particularly high need for palliative care. Since beds in specialist palliative care units are limited, the HPCT should be prepared to care for these patients. They may offer support in decision-making, optimize symptom control, and provide psychosocial care for patients and their families. Visiting restrictions aimed to protect the general public must be weighted against the patient's and family's suffering.
A compact dual band-notched SWB antenna with high bandwidth dimension ratio
Authors: Dastranj Aliakbar , Lari Ghazaleh , Bornapour Mosayeb 
Published: June 2020

AbstractIn this research, a compact dual band-notched (DBN) super-wideband (SWB) coplanar waveguide-fed antenna with high bandwidth (BW) dimension ratio of 7427.4 has been presented. The proposed antenna covers a very wide frequency range from 2.8 to 40 GHz (BW ratio of 14.28:1) with |S11|<−10 dB. The overall antenna size is 20 × 14 × 1.6 mm3 which consists of an FR4 substrate with a dielectric constant of 4.4, a shovel-shaped radiating patch and the symmetric stair-shaped ground plane. The DBN characteristics are achieved by employing a pair of C-shaped and circular slots on its shovel-shaped radiating patch to reject the interferences caused by two WiMAX (3.7–4.7 GHz) and WLAN (5.7–6.4 GHz) bands. The notched frequency bands can be controlled by changing the radii of slots. The SWB property of the antenna is obtained by using a symmetric stair-shaped ground plane and also a shovel-shaped radiating patch. The measured results of the fabricated prototype in frequency-and time-domain are also presented and compared with the numerical results. The results indicate that the antenna has good performance over the entire operating BW (173.8%) which makes it very potential candidate for modern SWB applications.
Protective effect of maternal exercise against amyloid-β neurotoxicity in the male rat offspring’s cerebellum
Authors: Klein Caroline Peres , Hoppe Juliana Bender , Saccomori André Brum , Gindri dos Santos Bernardo , August Pauline Maciel , Klein Isadora Peres , Crestani Mariana Scortegagna , Bifi Felippo , Hözer Régis Mateus , Navas Plácido , Salbego Christianne Gazzana , Matté Cristiane 
Published: June 2020

AbstractThe Developmental Origins of Health and Disease (DOHaD) states that intrauterine maternal environment influences postnatal life by programming offspring’s metabolism. Intrauterine milieu induced by exercise during pregnancy promotes long-lasting benefits to the offspring’s health and seems to offer some resistance against chronic diseases in adult life. Alzheimer’s disease is a public health concern with limited treatment options. In the present study, we assessed the potential of maternal exercise during pregnancy in long-term programming of young adult male rat offspring’s cerebellar metabolism in conferring neuroprotection against amyloid-β (Aβ) neurotoxicity. Female Wistar rats were submitted to a swimming protocol 1 week prior mating and throughout pregnancy (five sessions/a week lasting 30 min). Aβ oligomers were infused bilaterally in the brain ventricles of 60-day-old male offspring. Fourteen days after surgery, we measured parameters related to redox state, mitochondrial function, and the immunocontent of proteins related to synaptic function. We found that maternal exercise during pregnancy attenuated several parameters in the offspring’s male rat cerebellum, such as the reactive species rise, the increase of inducible nitric oxide synthase immunocontent and tau phosphorylation induced by Aβ oligomers, increased mitochondrial fission indicated by dynamin-related protein 1 (DRP1), and protein oxidation identified by carbonylation. Strikingly, we find that maternal exercise promotes changes in the rat offspring’s cerebellum that are still evident in young adult life. These favorable neurochemical changes in offspring’s cerebellum induced by maternal exercise may contribute to a protective phenotype against Aβ-induced neurotoxicity in young adult male rat offspring.
The Lithospheric Structure of the Saharan Metacraton From 3‐D Integrated Geophysical‐Petrological Modeling
Authors: Sobh M. , Ebbing J. , Mansi A. H. , Götze H.‐J. , Emry E. L. , Abdelsalam M. G. 
Published: June 2020

AbstractWe modeled crustal and lithospheric thickness variation as well as the variations in temperature, composition, S wave seismic velocity, and density of the lithosphere beneath the Saharan Metacraton (SMC) applying an interdisciplinary 3‐D modeling. Regardless of the limited data set, we aimed at consistent imaging of the SMC lithospheric structure by combining independent data sets to better understand the evolution of the metacraton. We considered that the SMC was once an intact Archean‐Paleoproterozoic craton but was metacratonized during the Neoproterozoic due to partial loss of its subcontinental lithospheric mantle (SCLM) during collisional processes along its margin. This has permitted the preservation of three cratonic remnants (Murzuq, Al‐Kufrah, and Chad) within the metacraton. These cratonic remnants are overlain by Paleozoic‐Mesozoic sedimentary basins (Murzuq, Al‐Kufrah, and Chad), which are separated by topographic swells associated with the Hoggar Swell, Tibesti Massif, and Darfur Dome Cenozoic volcanism. The three cratonic remnants are underlain by a relatively thicker lithosphere compared to the surrounding SMC, with the thickest located beneath Al‐Kufrah reaching 200 km. Also, the SCLM beneath Al‐Kufrah cratonic remnant is significantly colder and denser. Modeling of the lithosphere beneath the Chad and Murzuq Basins yielded a complex density and temperature distribution pattern, with lower values than beneath the Tibesti Massif. Further, our modeling indicated a uniform and moderately depleted mantle composition beneath the SMC. The presence of a relatively thinner lithosphere beneath the noncratonic regions of the SMC is attributed with several tectonic events, including partial SCLM delamination during the Neoproterozoic, Mesozoic‐Cenozoic rifting, and Cenozoic volcanism.
Stress Orientations in the Nankai Trough Constrained Using Seismic and Aseismic Slip
Authors: Newton Tyler J. , Thomas Amanda M. 
Published: June 2020

AbstractThe strength of subduction thrust faults is key to understanding seismogenesis at the provenance of Earth's largest earthquakes. Earthquake focal mechanisms are routinely inverted to constrain the stress state at seismogenic depths. However, on some megathrusts, deformation is accommodated by both earthquakes and types of slow fault slip. We employ focal mechanisms of short‐term slow slip events (SSEs), a type of slow fault slip, and earthquakes in a regional stress inversion to investigate the stress state of the Nankai Trough megathrust and interpret the results in the context of regional tectonics Previous studies using earthquake‐only stress inversions found principal stress orientations in this region that are incompatible with thrust faulting on the megathrust. When both SSEs and earthquakes are considered, the stress state of the central and eastern Nankai Trough megathrust is well oriented for thrust faulting. Our results suggest that slow fault slip source regions may appear to have misoriented stress fields if slow fault slip constitutes a substantial proportion of fault slip and the stress field is not well constrained by earthquakes. In the SSE region, we find that faults are well oriented for failure, suggesting they have strengths similar to their surroundings. Combined with low Vp/Vs ratios and sensitivity to small stress changes, our results imply that the megathrust and surroundings operate at low deviatoric stresses in the SSE source region. Further, we show that the coefficient of friction for areas hosting SSEs is low (μ=0.19–0.50), implying frictionally weak materials in the SSE source region.
Unravelling Effects of the Pore‐Size Correlation Length on the Two‐Phase Flow and Solute Transport Properties: GPU‐based Pore‐Network Modeling
Authors: An Senyou , Hasan Sharul , Erfani Hamidreza , Babaei Masoud , Niasar Vahid 
Published: June 2020

AbstractContinuum‐scale models for two‐phase flow and transport in porous media are based on the empirical constitutive relations that highly depend on the porous medium heterogeneity at multiple scales including the microscale pore‐size correlation length. The pore‐size correlation length determines the representative elementary volume and controls the immiscible two‐phase invasion pattern and fluids occupancy. The fluids occupancy controls not only the shape of relative permeability curves but also the transport zonation under two‐phase flow conditions, which results in the non‐Fickian transport. This study aims to quantify the signature of the pore‐size correlation length on two‐phase flow and solute transport properties such as the capillary pressure‐ and relative permeability‐saturation, dispersivity, stagnant saturation, and mass transfer rate. Given the capability of pore‐scale models in capturing the pore morphology and detailed physics of flow and transport, a novel graphics processing unit (GPU)‐based pore‐network model has been developed. This GPU‐based model allows us to simulate flow and transport in networks with multimillions pores, equivalent to the centimeter length scale. The impact of the pore‐size correlation length on all aforementioned properties was studied and quantified. Moreover, by classification of the pore space to flowing and stagnant regions, a simple semianalytical relation for the mass transfer between the flowing and stagnant regions was derived, which showed a very good agreement with pore‐network simulation results. Results indicate that the characterization of the topology of the stagnant regions as a function of pore‐size correlation length is essential for a better estimation of the two‐phase flow and solute transport properties.
Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy
Authors: Hawer Harmen , Mendelsohn Bryce A. , Mayer Klaus , Kung Ann , Malhotra Amit , Tuupanen Sari , Schleit Jennifer , Brinkmann Ulrich , Schaffrath Raffael 
Published: June 2020

AbstractWe describe a novel type of ribosomopathy that is defined by deficiency in diphthamidylation of translation elongation factor 2. The ribosomopathy was identified by correlating phenotypes and biochemical properties of previously described patients with diphthamide biosynthesis gene 1 (DPH1) deficiencies with a new patient that carried inactivating mutations in both alleles of the human diphthamide biosynthesis gene 2 (DPH2). The humanDPH1syndrome is an autosomal recessive disorder associated with developmental delay, abnormal head circumference (microcephaly or macrocephaly), short stature, and congenital heart disease. It is defined by variants with reduced functionality of theDPH1gene observed so far predominantly in consanguineous homozygous patients carrying identical mutant alleles ofDPH1. Here we report a child with a very similar phenotype carrying biallelic variants of the humanDPH2. The gene products DPH1 and DPH2 are components of a heterodimeric enzyme complex that mediates the first step of the posttranslational diphthamide modification on the nonredundant eukaryotic translation elongation factor 2 (eEF2). Diphthamide deficiency was shown to reduce the accuracy of ribosomal protein biosynthesis. Both DPH2 variants described here severely impair diphthamide biosynthesis as demonstrated in human and yeast cells. This is the first report of a patient carrying compound heterozygous DPH2 loss-of-function variants with aDPH1syndrome-like phenotype and implicates diphthamide deficiency as the root cause of this patient’s clinical phenotype as well as ofDPH1-syndrome. These findings define “diphthamide-deficiency syndrome” as a special ribosomopathy due to reduced functionality of components of the cellular machinery for eEF2-diphthamide synthesis.
Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics
Authors: Torpey James , Madine Jillian , Wood Amy , Lian Lu-Yun 
Published: June 2020

AbstractCyclophilin D (CypD) is a peptidyl-prolyl isomerase expressed in the nucleus and transported into the mitochondria where it is best associated with the regulation of the mitochondrial permeability transition pore (MPTP). There are, however, other possible roles of CypD in the mitochondria which may or may not be linked with the MPTP. Alpha synuclein (αSyn) is shown here to interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand binding pocket of CypD. The study shows that CypD binding with soluble αSyn prevents its aggregation. Furthermore, the addition of CypD to preformed αSyn fibrils leads to the disassembly of these fibrils. Enzymatically-compromised mutants of CypD show reduced abilities to dissociate αSyn aggregates, suggesting that fibril disassembly is linked to the increased rate of peptidyl-prolyl isomerisation catalysed by CypD. Protein aggregation in the mitochondria is increasingly seen as the cause of neurodegeneration. However, protein aggregation is a reversible process but disaggregation requires help from other proteins such as isomerases and chaperones. The results here demonstrate a possible mechanism by which CypD achieves this and suggest that disaggregation could be one of the many functions of this protein.
A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids
Authors: Cavo Marta , Delle Cave Donatella , D’Amone Eliana , Gigli Giuseppe , Lonardo Enza , del Mercato Loretta L. 
Published: June 2020

AbstractTumour spheroids have the potential to be used as preclinical chemo-sensitivity assays. However, the production of three-dimensional (3D) tumour spheroids remains challenging as not all tumour cell lines form spheroids with regular morphologies and spheroid transfer often induces disaggregation. In the field of pancreatic cancer, the MiaPaCa-2 cell line is an interesting model for research but it is known for its difficulty to form stable spheroids; also, when formed, spheroids from this cell line are weak and arduous to manage and to harvest for further analyses such as multiple staining and imaging. In this work, we compared different methods (i.e. hanging drop, round-bottom wells and Matrigel embedding, each of them with or without methylcellulose in the media) to evaluate which one allowed to better overpass these limitations. Morphometric analysis indicated that hanging drop in presence of methylcellulose leaded to well-organized spheroids; interestingly, quantitative PCR (qPCR) analysis reflected the morphometric characterization, indicating that same spheroids expressed the highest values of CD44, VIMENTIN, TGF-β1 and Ki-67. In addition, we investigated the generation of MiaPaCa-2 spheroids when cultured on substrates of different hydrophobicity, in order to minimize the area in contact with the culture media and to further improve spheroid formation.
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia
Authors: Mohammadi Fatemeh , Kohlmeier Kristi Anne , Jeddi Sajad , Ahmadi-Zeidabadi Meysam , Shabani Mohammad 
Published: June 2020

AbstractEmpathy for pain depends on the ability to feel, recognize, comprehend and share painful emotional conditions of others. In this study, we investigated the role of NO in a rat model of empathic pain. Pain was socially transferred from the sibling demonstrator (SD) who experienced five formalin injection to the naïve sibling observer (SO) through observation. SO rats received L-NAME (a nonspecific NO synthase inhibitor) or L-arginine (a precursor of NO) prior to observing the SD. Nociception, and concentrations of NO metabolites (NOx) in the serum, left and right hippocampus, prefrontal cortex, and cerebellum were evaluated. Nociceptive responses were significantly increased in the pain-observing groups. NOx levels measured 24 h after the last pain observation using the Griess method, were indicative of NOx concentration decreases and increases in the left hippocampus and cerebellum, respectively. There was an increase in tissue concentration of NOx in cerebellum and prefrontal cortex in both pain and observer groups 7 days after the fifth formalin injection. Our results suggest that NO is involved in development of empathic hyperalgesia, and observation of sibling’s pain can change NO metabolites in different brain regions in observer rats.
In-situ Raman analysis of hydrogenation in well-defined ultrathin molybdenum diselenide deposits synthesized through vapor phase deposition
Authors: Santiago Peter Joseph , Ramirez Francisco , Tavassol Hadi 
Published: June 2020

AbstractWe report on the synthesis, characterization and in-situ Raman spectroscopy analysis of hydrogenation in ultrathin crystalline MoSe2 deposits. We use a controllable vapor phase synthesis method using MoSe2 powder as the only precursor, to fabricate nano- to micro-size few layer thick MoSe2 deposits with tunable number densities on SiO2/Si substrates. We employ this controllable synthesis method to correlate characteristic Raman spectroscopy response of MoSe2 at ca. 242 cm−1 (A1g) and ca. 280 cm−1 (E2g1) with the thickness of the deposits acquired from atomic force microscopy (AFM). We also use this array of well-defined atomically thin MoSe2 deposits to study possible hydrogenation effects on select architectures using in-situ Raman spectroscopy. Interestingly, our analysis indicates that ultrathin MoSe2 deposits with exposed edges show a blue shift of 1–2 cm−1 when exposed to H2 flow at 150–250 sccm for 2–4 hours in a sealed reaction cell. Exposure to Ar flow under same condition reverses the observed shift in the A1g mode of the select MoSe2 deposits. Our measurements provide in-situ evidence for hydrogen adsorption on MoSe2 deposits at room temperature and insight into the possible active sites for hydrogen reactions on layered dichalcogenides at lower dimensions.
Based on Histogram Analysis: ADCaqp Derived from Ultra-high b-Value DWI could be a Non-invasive Specific Biomarker for Rectal Cancer Prognosis
Authors: Zhang Guangwen , Ma Wanling , Dong Hui , Shu Jun , Hou Weihuan , Guo Yong , Wang Mian , Wei Xiaocheng , Ren Jialiang , Zhang Jinsong 
Published: June 2020

AbstractAquaporins (AQP) are not only water channel protein, but also potential prognostic indicator and therapeutic target for rectal cancer. Some previous studies have demonstrated the AQP expression could be estimated by ADCaqp value derived from ultra-high b-value diffusion-weighted imaging (DWI). We aim to determine whether ADCaqp could be a new and specific biomarker for indicating the AQP expression and prognostic factors of rectal cancer. 76 untreated patients with rectal cancer confirmed by colonoscopy biopsy were enrolled. ADCaqp value was generated from ultra-high b-value DWI with five b-values (1700–3500 s/mm2). AQP (AQP1, 3 and 5)staining intensity was estimated by both of software (QuPath) and manual manner. The relationships between histogram features of ADCaqp and AQP staining intensity were analyzed. The correlations between histogram features of ADCaqp and differentiation degrees (good, moderate, poor), T stage (T1–2 vs T3–4), and lymph node status (N+ vs N−) were also evaluated respectively. The mean, 75th percentile and 97.5th percentile of ADCaqp were correlated with AQP1 staining intensity (r = 0.237, 0.323 and 0.362, respectively, all P < 0.05) . No correlation was found between the histogram features of ADCaqp and AQP3 or AQP5 staining intensity. The mean, 50th percentile, 75th percentile and 97.5th percentile of ADCaqp value exhibited significant differences between differentiation status (all P < 0.05). Histogram features of ADCaqp value showed no significant differences in two subgroups of T stage and lymph node status (all P > 0.05). Histogram analysis showed that the ADCaqp value derived from ultra-high b-value DWI of rectal cancer could reflect AQP1’s expression and rectal cancer’s malignancy degree. ADCaqp might be a new imaging biomarker for evaluating rectal cancer.