bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Patients with Relapsed or Refractory Mantle–Cell Lymphoma with Zanubrutinib, a Selective Inhibitor of Bruton's Tyrosine Kinase
Authors: Song Yuqin , Zhou Keshu , Zou Dehui , Zhou Jianfeng , Hu Jianda , Yang Haiyan , Zhang Huilai , Ji Jie , Xu Wei , Jin Jie , Lv Fangfang , Feng Ru , Gao Sujun , Guo Haiyi , Zhou Lei , Elstrom Rebecca , Huang Jane , Novotny William , Wei Rachel , Zhu Jun 
Published: May 2020

AbstractPurpose:Mantle-cell lymphoma (MCL) is an incurable mature B-cell neoplasm with high initial response rates followed almost invariably by relapse. Prognosis for patients following relapse is poor, and treatment choices are limited. We evaluated the efficacy and safety of zanubrutinib, an investigational selective Bruton's tyrosine kinase (BTK) inhibitor.Patients and Methods:Patients with relapsed/refractory MCL were enrolled in this ongoing phase II, single-arm, open-label study, and treated with oral zanubrutinib 160 mg twice daily. The primary endpoint is overall response rate (ORR) assessed by an independent review committee (per Lugano 2014 classification); secondary endpoints include duration of response (DOR), time to response, progression-free survival (PFS), and safety.Results:Eighty-six patients (median age, 60.5 years) were enrolled after a median of 2 prior lines of therapy, received ≥1 dose of the study drug, and were evaluable for safety and efficacy. After a median follow-up of 18.4 months, 72 (84%) patients achieved an objective response, with 59 (68.6%) achieving a complete response (CR). Median DOR and PFS were 19.5 and 22.1 months, respectively; 12-month event-free estimates for DOR and PFS are 78% and 76%, respectively. Most common grade ≥3 adverse events (AE) were neutropenia (19.8%) and lung infection/pneumonia (9.3%). Three patients experienced major bleeding events, and there were no reports of atrial fibrillation. Eight (9.3%) patients discontinued zanubrutinib for AEs.Conclusions:These results demonstrate high and durable ORR and CR rates in patients with relapsed/refractory MCL. Zanubrutinib was generally well tolerated; grade ≥3 BTK inhibitor-associated toxicities (hemorrhage, rash, hypertension, diarrhea, atrial fibrillation) were uncommon.
Palliative Care Consultation Reduces Heart Failure Transitions: A Matched Analysis
Authors: Diop Michelle S. , Bowen Garrett S. , Jiang Lan , Wu Wen‐Chih , Cornell Portia Y. , Gozalo Pedro , Rudolph James L. 
Published: May 2020

Background

Palliative care supports quality of life, symptom control, and goal setting in heart failure (
HF
) patients. Unlike hospice, palliative care does not restrict life‐prolonging therapy. This study examined the association between palliative care during hospitalization for
HF
on the subsequent transitions and procedures.

Methods and Results

Veterans admitted to hospitals with
HF
from 2010 to 2015 were randomly selected for the Veterans Administration External Peer Review Program. Variables pertaining to demographic, clinical, laboratory, and usage were captured from Veterans Administration electronic records. Patients receiving hospice services before admission were excluded. Patients who received palliative care were propensity matched to those who did not. The primary outcomes were whether the patient experienced transitions or procedures in the 6 months after admission. Transitions included multiple readmissions (≥2) or intensive care admissions and procedures included mechanical ventilation, pacemaker implantation, or defibrillator implantation. Among 57 182 hospitalized
HF
patients, 1431 received palliative care, and were well matched to 1431 without (standardized mean differences ≤ ±0.05 on all matched variables). Palliative care was associated with significantly fewer multiple rehospitalizations (30.9% versus 40.3%,
P
<0.001), mechanical ventilation (2.8% versus 5.4%,
P
=0.004), and defibrillator implantation (2.1% versus 3.6%,
P
=0.01). After adjustment for facility fixed effects, palliative care consultation was associated with a significantly reduced hazard of multiple readmissions (adjusted hazard ratio=0.73, 95% CI, 0.64–0.84) and mechanical ventilation (adjusted hazard ratio=0.76, 95% CI, 0.67–0.87).

Conclusions

Palliative care during
HF
admissions was associated with fewer readmissions and less mechanical ventilation. When available, engagement of
HF
patients and caregivers in palliative care for symptom control, quality of life, and goals of care discussions may be associated with reduced rehospitalizations and mechanical ventilation.
Digital Activism in Asia: Good, Bad, and Banal Politics Online
Authors: Barendregt Bart , Schneider Florian 
Published: May 2020

Abstract
This article introduces the special issue on ‘Digital Activism’ by exploring some of the trends in social media activism and scholarship thereof. The authors ask to what extent this literature helps us understand Asian forms of online activism, which forms of activism have relatively done well, and whether Asian activism requires its own theorizing. Most of all, it is a plea for a careful and ethnographically informed approach to digital activism. Although outwardly they look similar and use the same templates, manuals, or even similar media strategies, not all forms of online activism promote democratic values. Furthermore, we argue that much of what happens under the banner of digital activism is not necessarily politics with a capital P but, rather, consists of everyday forms of engagement, with sometimes seemingly vulgar contents and often familiar routines and natural forms, yet in their impact such ‘banal activism’ may have political implications.
North Atlantic Oscillation Effect on Interannual Variability in Winter Precipitation over the Gulf Stream
Authors: Sun Yue , Liu Jing-Wu , Xie Shang-Ping 
Published: May 2020

AbstractIn winter, the warm water of the Gulf Stream anchors a salient precipitation band. Previous studies suggested a close relationship between the sea surface temperature (SST) front and the precipitation band through sea level pressure (SLP) adjustment. This study uses 17 years of high-resolution precipitation observations to reveal that the variation in wintertime precipitation over the Gulf Stream is related to the North Atlantic Oscillation (NAO) at the interannual time scale. The moisture budget analysis shows that the climatological precipitation band is supported by the large evaporation from the Florida Current, mean flow, and synoptic moisture convergence within the boundary layer, with a negative contribution from mean-flow moisture advection by the prevailing northwesterlies. For interannual variability, by contrast, the negative contribution of mean-flow moisture advection significantly decreases due to anomalous southeasterlies west of the intensified Azores high at the positive NAO phase. The contributions from mean-flow moisture advection and mean and synoptic convergence vary greatly along the Gulf Stream. In addition, mean-flow and synoptic moisture convergences positively contribute to the precipitation band both in climatology and at the interannual time scale, indicative of a positive feedback between precipitation and boundary layer convergence. Our analysis suggests that the SLP adjustment mechanism across the SST front is still at work in interannual variability, and the variation of synoptic activities over the Gulf Stream plays an important role in modulating the frontal precipitation. By relating the frontal precipitation to the NAO, this study bridges small-scale air–sea interaction and large-scale atmospheric circulation.
Predicting Daily Mean Wind Speed in Europe Weeks ahead from MJO Status
Authors: Lledó Llorenç , Doblas-Reyes Francisco J. 
Published: May 2020

ABSTRACTThe Madden–Julian oscillation (MJO), a prominent feature of the tropical atmospheric circulation at subseasonal time scales, is known to modulate atmospheric variability in the Euro-Atlantic region. However, current subseasonal prediction systems fail to accurately reproduce the physical processes involved in these teleconnection mechanisms. This paper explores the observed impact of strong MJO events on surface wind speed over Europe. It is found that some MJO phases are accompanied by strong wind anomalies in Europe. After showing that this teleconnective mechanism is not present in the predictions of the ECMWF monthly forecasting system, a methodology to reconstruct forecasts of daily mean wind speed in the continent weeks ahead is proposed. This method combines MJO forecasts from the S2S project database and the observed teleconnection impacts in the historical records. Although it is found that strong MJO events cannot be skillfully predicted more than 10 days ahead with current prediction systems, a theoretical experiment shows that this method can effectively transform a dynamical MJO forecast into a probabilistic wind speed prediction in Europe.
Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis
Authors: Caussy Cyrielle , Chuang Jen-Chieh , Billin Andrew , Hu Tao , Wang Ya , Subramanian G. Mani , Djedjos C. Stephen , Myers Robert P. , Dennis Edward A. , Loomba Rohit 
Published: May 2020

Background: Eicosanoid and related docosanoid polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives have been proposed as noninvasive lipidomic biomarkers of nonalcoholic steatohepatitis (NASH). Therefore, we investigated associations between plasma eicosanoids and liver fibrosis to evaluate their utility in diagnosing and monitoring NASH-related fibrosis. Methods: Our analysis used baseline eicosanoid data from 427 patients with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD), and longitudinal measurements along with liver fibrosis staging from 63 patients with NASH and stage 2/3 fibrosis followed for 24 weeks in a phase II trial. Results: At baseline, four eicosanoids were significantly associated with liver fibrosis stage: 11,12-DIHETE, tetranor 12-HETE, adrenic acid, and 14, 15-DIHETE. Over 24 weeks of follow up, a combination of changes in seven eicosanoids [5-HETE, 7,17-DHDPA, adrenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), 16-HDOHE, and 9-HODE) had good diagnostic accuracy for the prediction of ⩾1 stage improvement in fibrosis (AUROC: 0.74; 95% CI: 0.62–0.87), and a combination of four eicosanoids (7,17-DHDPA, 14,15-DIHETRE, 9-HOTRE, and free adrenic acid) accurately predicted improvement in hepatic collagen content (AUROC: 0.72; 95% CI: 0.50–0.77). Conclusion: This study provides preliminary evidence that plasma eicosanoids may serve as noninvasive biomarkers of liver fibrosis and may predict liver fibrosis improvement in NASH.
Acute mesenteric ischaemia in refractory shock on veno-arterial extracorporeal membrane oxygenation
Authors: Renaudier Marie , de Roux Quentin , Bougouin Wulfran , Boccara Johanna , Dubost Baptiste , Attias Arié , Fiore Antonio , de’Angelis Nicola , Folliguet Thierry , Mulé Sébastien , Amiot Aurélien , Langeron Olivier , Mongardon Nicolas 
Published: May 2020

Abstract

Background
Acute mesenteric ischaemia is a severe complication in critically ill patients, but has never been evaluated in patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO). This study was designed to determine the prevalence of mesenteric ischaemia in patients supported by V-A ECMO and to evaluate its risk factors, as well as to appreciate therapeutic modalities and outcome.

Methods
In a retrospective single centre study (January 2013 to January 2017), all consecutive adult patients who underwent V-A ECMO were included, with exclusion of those dying in the first 24 hours. Diagnosis of mesenteric ischaemia was performed using digestive endoscopy, computed tomography scan or first-line laparotomy.

Results
One hundred and fifty V-A ECMOs were implanted (65 for post-cardiotomy shock, 85 for acute cardiogenic shock, including 39 patients after refractory cardiac arrest). Overall, median age was 58 (48–69) years and mortality 56%. Acute mesenteric ischaemia was suspected in 38 patients, with a delay of four (2–7) days after ECMO implantation, and confirmed in 14 patients, that is, a prevalence of 9%. Exploratory laparotomy was performed in six out of 14 patients, the others being too unstable to undergo surgery. All patients with mesenteric ischaemia died. Independent risk factors for developing mesenteric ischaemia were renal replacement therapy (odds ratio (OR) 4.5, 95% confidence interval (CI) 1.3–15.7, p=0.02) and onset of a second shock within the first five days (OR 7.8, 95% CI 1.5–41.3, p=0.02). Conversely, early initiation of enteral nutrition was negatively associated with mesenteric ischaemia (OR 0.15, 95% CI 0.03–0.69, p=0.02).

Conclusions
Acute mesenteric ischaemia is a relatively frequent but dramatic complication among patients on V-A ECMO.
Selection signatures in tropical cattle are enriched for promoter and coding regions and reveal missense mutations in the damage response gene HELB
Authors: Naval-Sánchez Marina , Porto-Neto Laercio R. , Cardoso Diercles F. , Hayes Ben J. , Daetwyler Hans D. , Kijas James , Reverter Antonio 
Published: May 2020

Abstract
Background
Distinct domestication events, adaptation to different climatic zones, and divergent selection in productive traits have shaped the genomic differences between taurine and indicine cattle. In this study, we assessed the impact of artificial selection and environmental adaptation by comparing whole-genome sequences from European taurine and Asian indicine breeds and from African cattle. Next, we studied the impact of divergent selection by exploiting predicted and experimental functional annotation of the bovine genome.

Results
We identified selective sweeps in beef cattle taurine and indicine populations, including a 430-kb selective sweep on indicine cattle chromosome 5 that is located between 47,670,001 and 48,100,000 bp and spans five genes, i.e. HELB, IRAK3, ENSBTAG00000026993, GRIP1 and part of HMGA2. Regions under selection in indicine cattle display significant enrichment for promoters and coding genes. At the nucleotide level, sites that show a strong divergence in allele frequency between European taurine and Asian indicine are enriched for the same functional categories. We identified nine single nucleotide polymorphisms (SNPs) in coding regions that are fixed for different alleles between subspecies, eight of which were located within the DNA helicase B (HELB) gene. By mining information from the 1000 Bull Genomes Project, we found that HELB carries mutations that are specific to indicine cattle but also found in taurine cattle, which are known to have been subject to indicine introgression from breeds, such as N’Dama, Anatolian Red, Marchigiana, Chianina, and Piedmontese. Based on in-house genome sequences, we proved that mutations in HELB segregate independently of the copy number variation HMGA2-CNV, which is located in the same region.

Conclusions
Major genomic sequence differences between Bos taurus and Bos indicus are enriched for promoter and coding regions. We identified a 430-kb selective sweep in Asian indicine cattle located on chromosome 5, which carries SNPs that are fixed in indicine populations and located in the coding sequences of the HELB gene. HELB is involved in the response to DNA damage including exposure to ultra-violet light and is associated with reproductive traits and yearling weight in tropical cattle. Thus, HELB likely contributed to the adaptation of tropical cattle to their harsh environment.
Extracting chemical reactions from text using Snorkel
Authors: Mallory Emily K. , de Rochemonteix Matthieu , Ratner Alex , Acharya Ambika , Re Chris , Bright Roselie A. , Altman Russ B. 
Published: May 2020

Abstract
Background
Enzymatic and chemical reactions are key for understanding biological processes in cells. Curated databases of chemical reactions exist but these databases struggle to keep up with the exponential growth of the biomedical literature. Conventional text mining pipelines provide tools to automatically extract entities and relationships from the scientific literature, and partially replace expert curation, but such machine learning frameworks often require a large amount of labeled training data and thus lack scalability for both larger document corpora and new relationship types.

Results
We developed an application of Snorkel, a weakly supervised learning framework, for extracting chemical reaction relationships from biomedical literature abstracts. For this work, we defined a chemical reaction relationship as the transformation of chemical A to chemical B. We built and evaluated our system on small annotated sets of chemical reaction relationships from two corpora: curated bacteria-related abstracts from the MetaCyc database (MetaCyc_Corpus) and a more general set of abstracts annotated with MeSH (Medical Subject Headings) term Bacteria (Bacteria_Corpus; a superset of MetaCyc_Corpus). For the MetaCyc_Corpus, we obtained 84% precision and 41% recall (55% F1 score). Extending to the more general Bacteria_Corpus decreased precision to 62% with only a four-point drop in recall to 37% (46% F1 score). Overall, the Bacteria_Corpus contained two orders of magnitude more candidate chemical reaction relationships (nine million candidates vs 68,0000 candidates) and had a larger class imbalance (2.5% positives vs 5% positives) as compared to the MetaCyc_Corpus. In total, we extracted 6871 chemical reaction relationships from nine million candidates in the Bacteria_Corpus.

Conclusions
With this work, we built a database of chemical reaction relationships from almost 900,000 scientific abstracts without a large training set of labeled annotations. Further, we showed the generalizability of our initial application built on MetaCyc documents enriched with chemical reactions to a general set of articles related to bacteria.
Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses
Authors: Kruse Colin P. S. , Meyers Alexander D. , Basu Proma , Hutchinson Sarahann , Luesse Darron R. , Wyatt Sarah E. 
Published: May 2020

Abstract
Background
Understanding of gravity sensing and response is critical to long-term human habitation in space and can provide new advantages for terrestrial agriculture. To this end, the altered gene expression profile induced by microgravity has been repeatedly queried by microarray and RNA-seq experiments to understand gravitropism. However, the quantification of altered protein abundance in space has been minimally investigated.

Results
Proteomic (iTRAQ-labelled LC-MS/MS) and transcriptomic (RNA-seq) analyses simultaneously quantified protein and transcript differential expression of three-day old, etiolated Arabidopsis thaliana seedlings grown aboard the International Space Station along with their ground control counterparts. Protein extracts were fractionated to isolate soluble and membrane proteins and analyzed to detect differentially phosphorylated peptides. In total, 968 RNAs, 107 soluble proteins, and 103 membrane proteins were identified as differentially expressed. In addition, the proteomic analyses identified 16 differential phosphorylation events. Proteomic data delivered novel insights and simultaneously provided new context to previously made observations of gene expression in microgravity. There is a sweeping shift in post-transcriptional mechanisms of gene regulation including RNA-decapping protein DCP5, the splicing factors GRP7 and GRP8, and AGO4,. These data also indicate AHA2 and FERONIA as well as CESA1 and SHOU4 as central to the cell wall adaptations seen in spaceflight. Patterns of tubulin-α 1, 3,4 and 6 phosphorylation further reveal an interaction of microtubule and redox homeostasis that mirrors osmotic response signaling elements. The absence of gravity also results in a seemingly wasteful dysregulation of plastid gene transcription.

Conclusions
The datasets gathered from Arabidopsis seedlings exposed to microgravity revealed marked impacts on post-transcriptional regulation, cell wall synthesis, redox/microtubule dynamics, and plastid gene transcription. The impact of post-transcriptional regulatory alterations represents an unstudied element of the plant microgravity response with the potential to significantly impact plant growth efficiency and beyond. What’s more, addressing the effects of microgravity on AHA2, CESA1, and alpha tubulins has the potential to enhance cytoskeletal organization and cell wall composition, thereby enhancing biomass production and growth in microgravity. Finally, understanding and manipulating the dysregulation of plastid gene transcription has further potential to address the goal of enhancing plant growth in the stressful conditions of microgravity.
Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
Authors: Ding Yao-dong , Pei Yu-qiang , Wang Rui , Yang Jia-xing , Zhao Yin-xin , Liu Xiao-li , Shen Hua , Ma Qian , Zhang Shuo , Ge Hai-long 
Published: May 2020

Abstract
Objective
Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA2) as a significant predictive factor for CSF remain controversial. The study aims to investigate the association between plasma Lp-PLA2 and CSF.

Methods
In this retrospective study, 170 consecutive patients who underwent coronary angiography were enrolled in Beijing Anzhen Hospital from January 2017 to September 2019, and were divided into CSF group and normal control groups. According to coronary blood flow rate measured by the thrombolysis in myocardial infarction frame count (TFC) method, CSF was defined as TFC > 27. Serum Lp-PLA2 levels were measured in an enzyme-linked immunosorbent assay.

Results
Lp-PLA2 levels were higher in the CSF group than in the control group (288.6 ± 50.3 versus 141.9 ± 49.7, P < 0.001) and were significantly correlated with the mean coronary artery thrombolysis in myocardial infarction (TIMI) frame count (r = 0.790, P<0.001). Logistic regression analysis showed that high Lp-PLA2 was independently associated with CSF after adjustment for conventional risk factors (OR = 1.040, CI = 1.022–1.059, P<0.001). Male sex (OR = 2.192, CI = 1.161–4.140, P = 0.016) and hypertension (OR = 1.965, CI = 1.034–3.736, P = 0.039) were also CSF risk factors. Receiver-operating characteristic curve (ROC) analysis showed that Lp-PLA2 levels can predict CSF severity; the predictive power was higher than the other risk factors.

Conclusion
Our study demonstrated that patients with CSF had higher circulating levels of Lp-PLA2 than normal controls. After adjustment for potential confounders, increased Lp-PLA2 was independently associated with presence of CSF.