bluuebunny/crossref_metadata_2025_split huggingface dataset:
Course Design Process to Create a Coordinated, Experiential, Integrated Core Operations Management Course for Business Majors
Authors: Hoefle Scott , Ott Willard B. , Scherpereel Christopher M. , Williams Susan K. 
Published: April 2020

ABSTRACTWe describe our process for transforming a traditional, core operations management/supply chain management (OM/SCM) course into an experiential, integrated, and coordinated course. We developed a vison to create a course that all business majors would find engaging and relevant and that faculty would teach consistently and at the same level of rigor. A primary result was three new learning outcomes that focused on concept integration across operations, the supply chain, and the business. We specifically focused on decision trade‐offs and the effects of OM/SCM decisions on other parts of operations, the supply chain, and the business. The redesigned course has been implemented for three semesters. Our experiences offer new insights for redesigning and coordinating an OM/SCM core course and a process that can be implemented in other redesign efforts.
Manipulation and Domestic Abuse in Contested Contact – Threats to Children's Participation Rights
Authors: Morrison Fiona , Tisdall E. Kay M. , Callaghan Jane E. M. 
Published: April 2020

The United Nations Convention on the Rights of the Child has catalysed numerous jurisdictions to introduce new legal provisions to support children's participation rights when child contact is contested. Despite this, children's participation is frequently limited in practice, especially in contexts where children are perceived as vulnerable to a parent's manipulation, even if there are allegations of domestic abuse. While “resist and refusal dynamics” have yet to become mainstream terms in Scottish family law, “manipulation” has become a common concern in cases of contested contact. Drawing on a Scottish empirical study on contested child contact in circumstances of domestic abuse, we interrogate the implications that the concept of manipulation has for children's participation rights. The study involved separate in‐depth interviews with 18 children and their 16 mothers. Findings point to concerns about upholding children's participation rights, particularly in cases where children were depicted as “influenced” or “manipulated.” Through our analysis, we disentangle the problems professionals have when concerns about child manipulation and domestic abuse intersect. We argue that, when combined, allegations of manipulation and domestic abuse present a significant and serious risk to children's participation rights. We find the legal construction of the child's views as separate from the parental dispute to have unintended and serious consequences for children's participation rights. We offer ways in which law and practice may evolve to ensure children's participation rights in these contexts are both implemented and upheld.Practitioner's Key Points
The combination of allegations of manipulation and domestic abuse present a significant and serious risk to children's participation rights in contested child contact
A legal construction of the child's views as separate to the parental dispute to have unintended and serious consequences for children's participation rights
Radical reform in family law and practice is necessary to make disputes about child contact centered around the child, rather than on parental responsibilities and rights.
The clinicopathological and molecular analysis of gastric cancer with altered SMARCA4 expression
Authors: Huang Shih‐Chiang , Ng Kwai‐Fong , Yeh Ta‐Sen , Cheng Chi‐Tung , Chen Min‐Chi , Chao Yi‐Chun , Chuang Huei‐Chieh , Liu Yu‐Jen , Chen Tse‐Ching 
Published: April 2020

AimsIn this study, we examine the clinicopathological and molecular features of gastric cancer (GC) with SMARCA4 alterations.Methods and resultsWe screened SMARCA4 alterations using immunohistochemistry on 1199 surgically resected GCs with information on Epstein–Barr virus (EBV), microsatellite instability (MSI) and other SWI/SNF subunits. SMARCA4, SMARCA2 and ARID1A mutations were investigated by targeted sequencing. The clinicopathological significance was determined by statistical analysis. Twenty‐seven cases (2%) with altered SMARCA4 expression were identified, exhibiting completely lost (six), reduced (nine) or heterogeneous (12) patterns. Frequent concomitant alterations of other SWI/SNF subunits were noted with an unusual discordant spatial heterogeneity. In comparison with SMARCA4‐retained GCs, SMARCA4‐lost GCs were observed more frequently in the non‐EBV/MSI subgroup (five of six) and reduced or heterogeneous SMARCA4 expression mainly occurred in EBV‐ or MSI‐associated cases (six of nine and six of 12, respectively; P < 0.001). Histologically, SMARCA4‐altered GC, irrespective of expression pattern, demonstrated divergent histomorphology, spanning tubular, poorly cohesive or mixed, neuroendocrine to solid and undifferentiated carcinoma, with a predilection to the latter two (P < 0.001). De‐differentiation‐like transition and rhabdoid features were noted in a minority of cases. For overall survival, altered SMARCA4 expression was an unfavourable prognostic factor in stage III, EBV‐associated GC and non‐EBV/MSI intestinal subtype (P ≤ 0.001). SMARCA4 or ARID1A mutations were detected mainly in SMARCA4‐lost or reduced GC, respectively.ConclusionsSMARCA4‐altered GCs are rare and have intratumoral heterogeneity, histomorphological diversity, conditional prognostic significance and various genetic drivers. SMARCA4‐lost GC may represent a genuine SMARCA4‐deficient neoplasm, but most SMARCA4‐reduced/heterogeneous cases are secondary to ARID1A collapse or associated with different genotypes.
The importance of using multiple outcome measures in infant research
Authors: LoBue Vanessa , Reider Lori B. , Kim Emily , Burris Jessica L. , Oleas Denise S. , Buss Kristin A. , Pérez‐Edgar Koraly , Field Andy P. 
Published: April 2020

AbstractCollecting data with infants is notoriously difficult. As a result, many of our studies consist of small samples, with only a single measure, in a single age group, at a single time point. With renewed calls for greater academic rigor in data collection practices, using multiple outcome measures in infant research is one way to increase rigor, and, at the same time, enable us to more accurately interpret our data. Here, we illustrate the importance of using multiple measures in psychological research with examples from our own work on rapid threat detection and from the broader infancy literature. First, we describe our initial studies using a single outcome measure, and how this strategy caused us to nearly miss a rich and complex story about attention biases for threat and their development. We demonstrate how using converging measures can help researchers make inferences about infant behavior, and how using additional measures allows us to more deeply examine the mechanisms that drive developmental change. Finally, we provide practical and statistical recommendations for how researchers can use multiple measures in future work.
Efficacy and safety of recombinant human epidermal growth factor for diabetic foot ulcers: A systematic review and meta‐analysis of randomised controlled trials
Authors: Zhao Ding‐Yun , Su Ya‐Na , Li Yong‐Hong , Yu Tian‐Qi , Li Jing , Tu Chong‐Qi 
Published: April 2020

AbstractTo evaluate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in treating diabetic foot ulcers (DFUs), we conducted both database searches (PubMed, MEDLINE, EMBASE, CENTRAL, and Web of Science) and reference searches for randomised controlled trials from the inception of databases to 30 January 2020. Two reviewers independently scrutinised the trials, extracted data, and assessed the quality of trials. The primary outcome was the proportion of complete healing. The secondary outcomes were mean time to complete healing and adverse events. A subgroup analysis was performed by different administration routes. Statistical analyses were performed in RevMan 5.3. The time to complete healing Kaplan‐Meier curves was pooled in the R software. Of the 156 citations, 9 trials (720 participants) met eligibility criteria and were included. The rhEGF achieved a higher complete healing rate than placebo (OR: 2.79, [95% CI: 1.99, 3.99]). The rhEGF also significantly shorten complete healing time (MD: −14.10 days, [95% CI: −18.03, −10.16]). Subgroup analysis showed that topical application was superior to intralesional injection, but that may be because of different ulcer severity they included. No significant difference was shown in adverse events. Results were coherent with sensitivity analyses. Therefore, rhEGF is an effective and safe treatment for DFUs.
Circulating microRNA profiles based on direct S‐Poly(T)Plus assay for detection of coronary heart disease
Authors: Su Mingyang , Niu Yanqin , Dang Quanjin , Qu Junle , Zhu Daling , Tang Zhongren , Gou Deming 
Published: April 2020

AbstractCoronary heart disease (CHD) is one of the leading causes of heart‐associated deaths worldwide. Conventional diagnostic techniques are ineffective and insufficient to diagnose CHD with higher accuracy. To use the circulating microRNAs (miRNAs) as non‐invasive, specific and sensitive biomarkers for diagnosing of CHD, 203 patients with CHD and 144 age‐matched controls (126 high‐risk controls and 18 healthy volunteers) were enrolled in this study. The direct S‐Poly(T)Plus method was used to identify novel miRNAs expression profile of CHD patients and to evaluate their clinical diagnostic value. This method is an RNA extraction‐free and robust quantification method, which simplifies procedures, reduces variations, in particular increases the accuracy. Twelve differentially expressed miRNAs between CHD patients and high‐risk controls were selected, and their performances were evaluated in validation set‐1 with 96 plasma samples. Finally, six (miR‐15b‐5p, miR‐29c‐3p, miR‐199a‐3p, miR‐320e, miR‐361‐5p and miR‐378b) of these 12 miRNAs were verified in validation set‐2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948‐0.993, P < .001) in a large cohort for CHD patients diagnosis. Plasma fractionation indicated that only a small amount of miRNAs were assembled into EVs. Direct S‐Poly(T)Plus method could be used for disease diagnosis and 12 unique miRNAs could be used for diagnosis of CHD.
The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes
Authors: Yang Hsiang‐Yu , Lin Feng‐Zhi , Yang Hui‐Wen , Yu Pei‐Ling , Huang Shih‐Ming , Chen Yao‐Chang , Tsai Chien‐Sung , Lin Chih‐Yuan 
Published: April 2020

AbstractThis study addressed the hypothesis that cardiac Sirtuin 1 (Sirt1) deficiency alters cardiomyocyte Ca2+ and Na+ regulation, leading to cardiac dysfunction and arrhythmogenesis. We used mice with cardiac‐specific Sirt1 knockout (Sirt1−/−). Sirt1flox/flox mice were served as control. Sirt1−/− mice showed impaired cardiac ejection fraction with increased ventricular spontaneous activity and burst firing compared with those in control mice. The arrhythmic events were suppressed by KN93 and ranolazine. Reduction in Ca2+ transient amplitudes and sarcoplasmic reticulum (SR) Ca2+ stores, and increased SR Ca2+ leak were shown in the Sirt1−/− mice. Electrophysiological measurements were performed using patch‐clamp method. While L‐type Ca2+ current (ICa, L) was smaller in Sirt1−/− myocytes, reverse‐mode Na+/Ca2+ exchanger (NCX) current was larger compared with those in control myocytes. Late Na+ current (INa, L) was enhanced in the Sirt1−/− mice, alongside with elevated cytosolic Na+ level. Increased cytosolic and mitochondrial reactive oxygen species (ROS) were shown in Sirt1−/− mice. Sirt1−/− cardiomyocytes showed down‐regulation of L‐type Ca2+ channel α1c subunit (Cav1.2) and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a), but up‐regulation of Ca2+/calmodulin‐dependent protein kinase II and NCX. In conclusions, these findings suggest that deficiency of Sirt1 impairs the regulation of intracellular Ca2+ and Na+ in cardiomyocytes, thereby provoking cardiac dysfunction and arrhythmogenesis.
In vivo accuracy of dental magnetic resonance imaging in assessing maxillary molar furcation involvement: A feasibility study in humans
Authors: Juerchott Alexander , Sohani Meysam , Schwindling Franz Sebastian , Jende Johann M. E. , Kurz Felix T. , Rammelsberg Peter , Heiland Sabine , Bendszus Martin , Hilgenfeld Tim 
Published: April 2020

AbstractAimTo investigate the accuracy and reliability of dental magnetic resonance imaging (dMRI) in assessing maxillary molar furcation involvement (FI).Material and MethodsIn this prospective study, 22 patients with severe periodontitis underwent cone‐beam computed tomography (CBCT) and dMRI. For 192 furcation entrances, the degree of horizontal FI was assessed by two independent observers on both modalities. Results of dMRI were compared with CBCT (reference modality) to assess the accuracy of dMRI. Cohen's kappa (κ), sensitivity and specificity were calculated for FI classification. Bland–Altman analysis and the Kruskal–Wallis test were used to evaluate measurement accuracy of dMRI.ResultsBased on CBCT findings, 93 furcation entrances revealed FI (degree I/II/III: 35/19/39). Intra‐ and inter‐reader agreement was excellent for both modalities (κ‐range: 0.884 to 0.933). dMRI measurements showed high agreement with CBCT (bias: 0.17 mm; 95% limits of agreement: −1.05 to 1.38 mm), and measurement accuracy did not differ among different degrees of FI (p = .67). For FI detection, sensitivity and specificity of dMRI were 98% and 99%. For FI classification, sensitivity values of dMRI were 89%/84%/100% for degree I/II/III.ConclusionsCompared to CBCT (non‐invasive gold standard), dMRI demonstrates high accuracy and reliability in evaluating the degree of FI in maxillary molars.
Rethinking environmental LCA life stages for transport infrastructure to facilitate holistic assessment
Authors: Saxe Shoshanna , Kasraian Dena 
Published: April 2020

AbstractLife cycle assessment (LCA) aims to provide a near full accounting of impacts from the complete life of a product, to avoid burden shifting between different parts of the life cycle. However, this is exceptionally difficult with transport infrastructure because important parts of their impact lie outside the widely applied industrial‐product‐oriented LCA life stages: production, manufacturing, use, and end of life. To account for those missing impacts, we propose a new framework for assessing the life cycle impacts of transport infrastructure. This framework takes account of the differences between transport infrastructure and the industrial product system to which LCA is most attuned. First, rather than a linear process from material extraction to disposal, this LCA framework accommodates the multiple iterations of transport infrastructure through circular life stages. These reflect the long lifetimes, durability, persistence, and feedback loops of transport infrastructure. Second, this framework recognizes the impact at the start of the life cycle created by demolition of previous infrastructure or land clearing. Third, the tightly linked external impacts that transport infrastructure induces, including influences on travel behavior, local land use, land use, land use change and forestry, and network effects are captured. Fourth, this framework recharacterizes “end of life” as “partial end of life,” in reflection of the widespread reconstruction, major refurbishment of and persistence of indirect impacts from transport infrastructure.
Aberrant retinoic acid production in the decidua: Implications for pre‐eclampsia
Authors: Rajakumar Augustine , Kane Maureen A. , Yu Jie , Taylor Robert N. , Sidell Neil 
Published: April 2020

AbstractFine‐tuning of the endometrium during the evanescent ‘window of implantation’ relies upon an array of diverse and redundant signaling molecules, particularly the ovarian steroids E2 and P4, but also growth factors, eicosanoids, and vitamins including the vitamin A compounds (retinoids). Pregnancy complications such as preeclampsia (PE) can result from aberrations in the production or function of these molecules that arise during this critical period of decidual development. Such aberrations may be reflected by incomplete decidualization, reduced spiral artery modification, and/or loss of immune tolerance to the developing fetus. Our understanding of the role of the active retinoid metabolite all‐trans retinoic acid (RA) in maintaining immune balance in certain tissues, along with data describing its role in decidualization, present a compelling argument that aberrant RA signaling in the decidua can play a significant role in the etiology of PE. Recent findings that decidualization and expression of the anti‐angiogenic gene product, ‘soluble fms‐like tyrosine kinase‐1’ (sFLT1) are negatively correlated and that sFLT1 expression is directly inhibited by RA, provide additional evidence of the critical role of this retinoid in regulating early vascular development in the decidua. This review provides insight into the production and function of RA in the decidua and how modifications in its metabolism and signaling might lead to certain pregnancy disorders such as PE.
Impact of Syrian refugees on congenital TORCH infections screening in Turkey
Authors: Çoşkun Bora , Gülümser Çağrı , Çoşkun Buğra , Artuk Cumhur , Karaşahin Kazım E. 
Published: April 2020

AbstractAimTo demonstrate the effect of the Syrian refugee population on the prevalence of congenital TORCH (Toxoplasmosis, Other [syphilis, varicella‐zoster, parvovirus B19], Rubella, Cytomegalovirus [CMV] and Herpes) infections and to evaluate the cost‐effectiveness of population‐based TORCH screening during pregnancy in Turkey.MethodsPregnant women (n = 9754) were enrolled. Ultrasonographic findings, immunoglobulin (Ig)M and IgG seropositivity, avidity, amniocentesis and DNA‐polymerase chain reaction (PCR) results were compared. Costs were calculated based on invoice amounts from the Health Applications Communique pricing system.ResultsThe prevalence of TORCH seropositivity in Turkey was not significantly different between all regions (P > 0.05). Overall, 1333 (13.67%) pregnant Syrian refugees were included in the study. Acute CMV, rubella and Toxoplasma gondii infections (according to low IgG avidity in IgM positive patients) were detected in 17.82%, 21.53% and 14.07% of women, respectively. Twenty‐four women underwent an amniocentesis procedure and nine of them had positive DNA‐PCR and reverse transcription‐PCR results. All women with positive results opted to terminate the pregnancy. There was no statistical difference among groups according to the rate of low IgG avidity in IgM‐positive patients and termination rates for T. gondii, rubella and CMV (P > 0.05). Total cost for screening the entire study population was presented in US dollars (USD). A total of 71 529 and prenatal diagnosis with positive invasive test results were obtained in nine women: toxoplasmosis in four, CMV in three and rubella in two women.ConclusionPopulation‐based screening for prenatal TORCH infections is not cost‐effective in Turkey. Syrian refugees have a limited effect on the increasing prevalence of congenital TORCH infections.
TheK‐Stateemoji scale, a cross‐cultural validation with adults
Authors: Deubler Grace , Swaney‐Stueve Marianne 
Published: April 2020

AbstractThe continued interest in emoji as a medium for measuring emotional response and the need for scales appropriate for cross‐cultural research were the drivers for this study. Experiments using 299 flavored potato chip consumers in the US and China were conducted to understand the suitability of the K‐State emoji scale for measuring emotional response to food products. Adults in each country were asked to evaluate flavored potato chips using a traditional nine‐point hedonic scale and the K‐State emoji scale. The K‐State emoji scale was found to be as equally discriminating as the nine‐point scale, and the scoring from the two scales followed similar distribution patterns and were highly correlated. When asked about the K‐State emoji scale's appropriateness, a significantly higher number of participants in China felt it was “appropriate” or “very appropriate” for the task compared to participants in the US. The findings presented here suggest the K‐State emoji scale is applicable in both countries, however, may be more suitable for the Chinese adult consumer.Practical ApplicationThe K‐State emoji scale is a suitable method for measuring emotion response to consumer products. It has been validated with children and adults in the US and China. The scale is intuitive, visual, and easy to use. The K‐State emoji scale is free to use.
CirculatingmicroRNAas biomarkers of canine mammary carcinoma in dogs
Authors: Fish Eric J. , Martinez‐Romero Esther Gisela , DeInnocentes Patricia , Koehler Jey W. , Prasad Nripesh , Smith Annette N. , Bird Richard Curt 
Published: April 2020

AbstractBackgroundDifferentiating benign from canine malignant mammary tumors requires invasive surgical biopsy. Circulating microRNAs (miRNA) may represent promising minimally invasive cancer biomarkers in people and animals.ObjectivesTo evaluate the serum mRNA profile between dogs with and without mammary carcinoma, and to determine if any of these markers have prognostic significance.AnimalsTen healthy client‐owned female dogs (5 intact, 5 spayed) and 10 dogs with histologically confirmed mammary carcinoma were included; 9 were client‐owned, whereas 1 was a research colony dog.MethodsRetrospective study. Serum miRNA was evaluated by RNA deep‐sequencing (RNAseq) and digital droplet PCR (dPCR).Expression of candidate biomarkers miR‐18a, miR‐19b, miR‐29b, miR‐34c, miR‐122, miR‐125a, and miR‐181a was compared with clinical characteristics, including grade, metastasis, and survival.Results452 unique serum miRNAs were detected by RNAseq. Sixty‐five individual miRNAs were differentially expressed (>±1.5‐fold) and statistically significant between groups. Serum miR‐19b (P= .003) and miR‐125a (P < .001) were significantly higher in the mammary carcinoma group by dPCR. Both had high accuracy based on receiver operator characteristic area under the curve (0.930 for miR‐125a; 0.880 for miR‐19b). Circulating miR‐18a by RNAseq was significantly higher in mammary carcinoma dogs with histologic evidence of lymphatic invasion (P= 0.03). There was no significant association with any miRNA and survival or inflammatory status.Conclusions and Clinical ImportanceCirculating miRNAs are differentially expressed in dogs with mammary carcinoma. Serum miR‐19b and miR‐18a represent candidate biomarkers for diagnosis and prognosis, respectively.