bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fusarium oxysporum infection activates the plastidial branch of the terpenoid biosynthesis pathway in flax, leading to increased ABA synthesis
Authors: Boba Aleksandra , Kostyn Kamil , Kozak Bartosz , Wojtasik Wioleta , Preisner Marta , Prescha Anna , Gola Edyta M. , Lysh Dzmitry , Dudek Barbara , Szopa Jan , Kulma Anna 
Published: January 2020

Abstract
Main conclusion

Upregulation of the terpenoid pathway and increased ABA content in flax uponFusarium infection leads to activation of the early plant’s response (PR genes, cell wall remodeling, and redox status).

Abstract
Plants have developed a number of defense strategies against the adverse effects of fungi such as Fusarium oxysporum. One such defense is the production of antioxidant secondary metabolites, which fall into two main groups: the phenylpropanoids and the terpenoids. While functions and biosynthesis of phenylpropanoids have been extensively studied, very little is known about the genes controlling the terpenoid synthesis pathway in flax. They can serve as antioxidants, but are also substrates for a plethora of different compounds, including those of regulatory functions, like ABA. ABA’s function during pathogen attack remains obscure and often depends on the specific plant-pathogen interactions. In our study we showed that in flax the non-mevalonate pathway is strongly activated in the early hours of pathogen infection and that there is a redirection of metabolites towards ABA synthesis. The elevated synthesis of ABA correlates with flax resistance to F. oxysporum, thus we suggest ABA to be a positive regulator of the plant’s early response to the infection.
Subjective recovery from pregnancy-related pelvic girdle pain the first 6 weeks after delivery: a prospective longitudinal cohort study
Authors: Gausel Anne Marie , Malmqvist Stefan , Andersen Knut , Kjærmann Inger , Larsen Jan Petter , Dalen Ingvild , Økland Inger 
Published: January 2020

Abstract
Purpose
The purpose of this study was to investigate the subjective recovery from pregnancy-related pelvic girdle pain (PGP) during the first 6 weeks after delivery and to detect possible risk factors for a poor recovery.

Methods
The participants were included in this study at the routine ultrasound examination at 18 weeks of pregnancy. The women received a weekly SMS with the question “How many days during the last week has your PGP been bothersome?” The SMS-track from the final 10 weeks of pregnancy and first 6 weeks after delivery were assessed and sorted, based on individual graphs. A total of 130 women who reported PGP during pregnancy and met for clinical examination 6 weeks after delivery were included in the study.

Results
In all, 83% of the women experienced substantial recovery from severe or moderate PGP within 6 weeks after delivery. Of these, 44% reported a substantial recovery already within 2 weeks after delivery. More multiparous women, women reporting PGP the year before pregnancy, and women with high pain intensity during pregnancy had a poor recovery.

Conclusions
The prognosis following PGP in pregnancy is good and the majority of women recovered substantially from severe and moderate pregnancy-related PGP within 6 weeks after delivery. For many women, a subjective substantial recovery occurred within 2 weeks after delivery. Predictors for a poor recovery were multiparity, PGP the year before pregnancy and a high pain intensity during pregnancy.

Graphic abstract
These slides can be retrieved under Electronic Supplementary Material.
International league of associations for rheumatology recommendations for the management of psoriatic arthritis in resource-poor settings
Authors:   on behalf of ILAR-PsA recommendations group, Elmamoun M. , Eraso M. , Anderson M. , Maharaj A. , Coates L. , Chandran Vinod , Abogamal A. , Adebajo A. O. , Ajibade A. , Ayanlowo O. , Azevedo V. , Bautista-Molano W. , Carneiro S. , Goldenstein-Schainberg C. , Hernandez-Velasco F. , Ima-Edomwonyi U. , Lima A. , Medina-Rosas J. , Mody G. M. , Narang T. , Ortega-Loayza A. G. , Ranza R. , Sharma A. , Toloza S. , Vega-Espinoza L. , Vega-Hinojosa O. 
Published: January 2020

AbstractBackgroundPsoriatic arthritis (PsA) is a challenging heterogeneous disease. The European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) last published their respective recommendations for the management of PsA in 2015. However, these guidelines are primarily based on studies conducted in resource replete countries and may not be applicable in countries in the Americas (except Canada and USA) and Africa. We sought to adapt the existing recommendations for these regions under the auspices of the International League of Associations for Rheumatology (ILAR).ProcessThe ADAPTE Collaboration (2009) process for guideline adaptation was followed to adapt the EULAR and GRAPPA PsA treatment recommendations for the Americas and Africa. The process was conducted in three recommended phases: set-up phase; adaptation phase (defining health questions, assessing source recommendations, drafting report), and finalization phase (external review, aftercare planning, and final production).ResultILAR recommendations have been derived principally by adapting the GRAPPA recommendations, additionally, EULAR recommendations where appropriate and supplemented by expert opinion and literature from these regions. A paucity of data relevant to resource-poor settings was found in PsA management literature.ConclusionThe ILAR Treatment Recommendations for PsA intends to serve as reference for the management of PsA in the Americas and Africa. This paper illustrates the experience of an international working group in adapting existing recommendations to a resource-poor setting. It highlights the need to conduct research on the management of PsA in these regions as data are currently lacking.Key Points•The paper presents adapted recommendations for the management of psoriatic arthritis in resource-poor settings.•The ADAPTE process was used to adapt existing GRAPPA and EULAR recommendations by collaboration with practicing clinicians from the Americas and Africa.•The evidence from resource-poor settings to answer clinically relevant questions was scant or non-existent; hence, a research agenda is proposed.
Cardiovascular magnetic resonance feature tracking in pigs: a reproducibility and sample size calculation study
Authors: Faragli A. , Tanacli R. , Kolp C. , Lapinskas T. , Stehning C. , Schnackenburg B. , Lo Muzio F. P. , Perna S. , Pieske B. , Nagel E. , Post H. , Kelle S. , Alogna A. 
Published: January 2020

AbstractCardiovascular magnetic resonance feature tracking (CMR-FT) is a novel technique for non-invasive assessment of myocardial motion and deformation. Although CMR-FT is standardized in humans, literature on comparative analysis from animal models is scarce. In this study, we measured the reproducibility of global strain under various inotropic states and the sample size needed to test its relative changes in pigs. Ten anesthetized healthy Landrace pigs were investigated. After baseline (BL), two further steps were performed: (I) dobutamine-induced hyper-contractility (Dob) and (II) verapamil-induced hypocontractility (Ver). Global longitudinal (GLS), circumferential (GCS) and radial strain (GRS) were assessed. This study shows a good to excellent inter- and intra-observer reproducibility of CMR-FT in pigs under various inotropic states. The highest inter-observer reproducibility was observed for GLS at both BL (ICC 0.88) and Ver (ICC 0.79). According to the sample size calculation for GLS, a small number of animals could be used for future trials.
Effectiveness and safety of eribulin in Japanese patients with HER2-negative, advanced breast cancer: a 2-year post-marketing observational study in a real-world setting
Authors: Inoue Kenichi , Takahashi Masato , Mukai Hirofumi , Yamanaka Takashi , Egawa Chiyomi , Sakata Yukinori , Ikezawa Hiroki , Matsuoka Toshiyuki , Tsurutani Junji 
Published: January 2020

SummaryBackground Data on eribulin as the first- or second-line treatment in a clinical setting, especially the overall survival (OS) of patients, are scarce. Therefore, we assessed the effectiveness and safety of eribulin as the first-, second-, and third- or later-line treatments in patients with human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in Japan. Methods This multicenter, prospective, post-marketing, observational study enrolled patients from September 2014 to February 2016 in Japan and followed them for 2 years. Patients were categorized by eribulin use into the first-, second-, and third- or later-line treatment groups. Results Of 651 registered patients, 637 patients were included in the safety and effectiveness analysis. In all, first-, second-, and third or later-line treatment groups, median OS (95% confidence interval) were 15.6 (13.8–17.6), 22.8 (17.3–31.0), 16.3 (12.4–19.9), and 12.6 (11.2–15.1) months and time to treatment failure (TTF) (95% confidence interval) were 4.2 (3.7–4.4), 5.2 (3.7–5.9), 4.2 (3.7–5.1), and 3.8 (3.5–4.2) months, respectively. Prolonged TTF was associated with complications of diabetes and the development of peripheral neuropathy after eribulin treatment, according to multivariate Cox regression analysis. Grade ≥ 3 adverse drug reactions (ADRs) were reported in 61.7% of the patients. Neutropenia (49.5%) was the most common grade ≥ 3 ADR in all groups. Conclusions The effectiveness and safety results of eribulin as the first- or second-line treatment were favorable. Thus, these suggest eribulin may be a first-line treatment candidate for patients with HER2-negative advanced breast cancer in Japan.
Transforming mathematics classroom practice through participatory action research
Authors: Wright Pete 
Published: January 2020

AbstractThis paper explores the potential of participatory action research to bring about significant changes in practice in a context in which more conventional approaches to research have had limited impact. It focuses on secondary mathematics classrooms where teaching approaches characterised by memorising and practising mathematical procedures, with little understanding of their application, purpose or underlying concepts, remain commonplace in many countries around the world and have proved highly resistant to change. The paper highlights the damage caused by such practices in terms of the alienation of large numbers of students and the inequitable outcomes they are associated with, including the strong correlation that persists between students’ socio-economic status and mathematical attainment. It reports on the case of one participatory action research project, involving the author and five teacher researchers, that demonstrated how a vision of mathematics education, involving a genuinely engaging and empowering curriculum, can be translated into classroom practice. The paper considers the extent to which this research project was conducted in a collaborative, systematic and rigorous way. It reflects on the research processes that facilitated critical reflection, enabled the teacher researchers to overcome constraints and generated trustworthy findings. The insights gained from this analysis are used to argue that a participatory action research methodology, which resonates with a critical mathematics pedagogy, has the potential to challenge prevailing discourses in mathematics education and hence lead to genuine transformations in classroom practice.
Comparison of Women from Georgia and Contiguous States Who Obtained Abortions in Georgia, 1994–2016
Authors: Shapiro Rachel , Erhardt-Ohren Blake , Rochat Roger 
Published: January 2020

Abstract
Objectives
To determine trends for Georgia and contiguous state residents seeking abortions in Georgia between 1994 and 2016.

Methods
We analyzed aggregate vital statistics data, collected in Georgia, on Georgia residents (n = 675,995) and contiguous state residents (Alabama, Florida, North Carolina, South Carolina, Tennessee) (n = 76,232) obtaining abortion and delivery services in Georgia between 1994 and 2016. We examined demographic, pregnancy, and abortion characteristics using counts, ratios, and χ2 tests of proportion.

Results
Of the data analyzed, 10.1% of all abortions were for contiguous state residents. The number of abortions in Georgia for contiguous state residents increased 35.3% from 1994 to 2016 (from n = 3115 to n = 4216) while it decreased for Georgia residents by 11.1% (from n = 32,934 to n = 29,264). Contiguous state residents exhibited a higher abortion ratio (1115) compared to Georgia women (224). These populations exhibited statistically significant differences across all variables and time points. Both populations demonstrated similar trends in ethnicity, race, education, marital status, and age. However, contiguous state residents were more likely to obtain an abortion at ≥ 20 weeks gestational age (13.8%) and obtained a lower proportion of suction curettage abortions (60.0%) and a higher proportion of dilation and evacuation procedures (31.9%). They were also less likely to be primigravid.

Conclusions for Practice
Women from neighboring states seek abortions in Georgia later in gestation and may therefore lack affordable, safe, early abortion care in their home states. Understanding trends in travel for abortion can allow providers and policymakers to better respond to the needs of patients.
Correlation of Elastohydrodynamic Friction with Molecular Structure of Highly Refined Hydrocarbon Base Oils
Authors: Kim Hak Mook , Spikes Hugh 
Published: January 2020

AbstractThe molecular compositions of a range of low viscosity hydrocarbon base oils spanning API Groups II to IV have been quantified using 13C NMR and correlated with base oil elastohydrodynamic (EHD) friction. A strong correlation has been found between the proportions of paraffin, linear and branched carbons and EHD friction, with a high proportion of linear and paraffinic carbon atoms contributing to low-EHD friction but branched carbons contributing to high-EHD friction. Correlation equations have been developed to predict EHD friction based on base oil composition. At very high temperature and low pressure, this correlation breaks down as the lubricant in the contact does not reach sufficiently high shear stress for shear thinning to occur. For Group IV polyalphaolefin, the correlation must be extended to account for the very high proportion of linear carbons originating from linear alkene oligomerization. The correlations developed in this study can be used to guide the design of low-EHD friction base oils.
Fast, robust, and accurate monocular peer-to-peer tracking for surgical navigation
Authors: Strzeletz Simon , Hazubski Simon , Moctezuma José-Luis , Hoppe Harald 
Published: January 2020

Abstract
Purpose

This work presents a new monocular peer-to-peer tracking concept overcoming the distinction between tracking tools and tracked tools for optical navigation systems. A marker model concept based on marker triplets combined with a fast and robust algorithm for assigning image feature points to the corresponding markers of the tracker is introduced. Also included is a new and fast algorithm for pose estimation.

Methods

A peer-to-peer tracker consists of seven markers, which can be tracked by other peers, and one camera which is used to track the position and orientation of other peers. The special marker layout enables a fast and robust algorithm for assigning image feature points to the correct markers. The iterative pose estimation algorithm is based on point-to-line matching with Lagrange–Newton optimization and does not rely on initial guesses. Uniformly distributed quaternions in 4D (the vertices of a hexacosichora) are used as starting points and always provide the global minimum.

Results

Experiments have shown that the marker assignment algorithm robustly assigns image feature points to the correct markers even under challenging conditions. The pose estimation algorithm works fast, robustly and always finds the correct pose of the trackers. Image processing, marker assignment, and pose estimation for two trackers are handled in less than 18 ms on an Intel i7-6700 desktop computer at 3.4 GHz.

Conclusion

The new peer-to-peer tracking concept is a valuable approach to a decentralized navigation system that offers more freedom in the operating room while providing accurate, fast, and robust results.
Cortical 3-hinges could serve as hubs in cortico-cortical connective network
Authors: Zhang Tuo , Li Xiao , Jiang Xi , Ge Fangfei , Zhang Shu , Zhao Lin , Liu Huan , Huang Ying , Wang Xianqiao , Yang Jian , Guo Lei , Hu Xiaoping , Liu Tianming 
Published: January 2020

AbstractMapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function.
Trocar Site HERnias After Bariatric Laparoscopic Surgery (HERBALS): a Prospective Cohort Study
Authors: Karampinis Ioannis , Lion Eliette , Hetjens Svetlana , Vassilev Georgi , Galata Christian , Reissfelder Christoph , Otto Mirko 
Published: January 2020

Abstract
Background
The exact prevalence of trocar site hernias after bariatric procedures is not yet known. Recent metaanalysis data indicated concerning rates of up to 25%. We conducted a prospective cohort study to estimate the prevalence and analyze the role of fascia closure in the development of trocar hernias.

Method
A total of 365 patients who were operated for obesity in our department between 2009 and 2018 were included. All patients were invited for a follow-up ultrasonography scan in order to detect abdominal wall defects. The role of intraoperative fascia closure in the development of trocar site hernias was evaluated, and a logistic regression analysis was performed to detect potential risk factors.

Results
The overall prevalence of trocar hernias detected by ultrasonography was 34%. The prevalence of abdominal wall defects in patients who received a fascia closure was 37% compared with 34% in patients who did not receive a fascia closure (p = 0.37). The only factor that was associated with a higher risk for trocar site hernias was high excessive weight loss (p = 0.05).

Conclusion
Trocar site hernias are an underestimated complication of minimally invasive, multiportal bariatric surgery, and the prevalence of asymptomatic hernias is probably higher than initially expected. In this study, fascia closure did not protect against trocar hernias. However, opposing evidence from similar trials suggests closing the fascia. This clinical problem should therefore be further assessed in a prospective randomized setting.
Comparison study on potential syngas produced by mild thermoconversion of microalgal residues through proton nuclear magnetic resonance and thermogravimetric analysis-fourier transform infrared spectroscopy
Authors: Li Shuangfei , Liu Liangxu , Cheng Jay Jiayang , Yang Xuewei 
Published: January 2020

AbstractThis paper presented a mechanism study of syngas production through lipid-extracted microalgal residues by investigating how the structure of these residues affected the pyrolysis characteristics. The results showed that both Chlorella sorokiniana 21 and Monoraphidium 3s35 residues could be pyrolyzed efficiently at low temperatures from 120 to 380 °C, with a final residue of less than 22.75%. Hemicellulose with carboxyl groups was the main component of both microalgal residues, most likely contributing to the production of the C=O compounds and carbon monoxide (CO). A large amount of CHO, CH2O, and CH3O (60.09% in total) was observed from C. sorokiniana 21, which was 1.58 times more than that from Monoraphidium 3s35. Pyrolysis of the C. sorokiniana 21 residue yielded more C=O and CHn compounds with less activation energy (52.97–58.57 kJ mol−1) and a higher reaction rate (0.105% s−1) than that of Monoraphidium 3s35. The different pyrolysis characteristics between the two microalgal residues might be attributed to structural variations.
Multiple hormone secretion may indicate worse prognosis in patients with ectopic Cushing’s syndrome
Authors: Lase Ieva , Strele Ieva , Grönberg Malin , Kozlovacki Gordana , Welin Staffan , Janson Eva Tiensuu 
Published: January 2020

Abstract
Purpose
Ectopic Cushing’s syndrome (ECS) caused by an ACTH secreting neuroendocrine neoplasm (NEN) is a rare and challenging condition. We aimed to detect predictive and prognostic parameters for ECS patients identified from a retrospective, comprehensive cohort of NENs treated at a tertiary referral center.

Methods
Medical records of 886 patients with NENs were reviewed. We identified 51 patients with ECS (33 females/18 men); mean age 52 ± 15 years (SD). Clinical parameters including symptoms, biochemical markers, and survival were extracted and further analyzed.

Results
The primary tumor was located in the thorax (n = 28) or pancreas (n = 15) or was of unknown primary origin (n = 8). In 30 patients, tumor and ECS were diagnosed simultaneously. In 12 patients, the NEN diagnosis preceded ECS development, with a median time of 43.5 months (range: 9–96), and 10 of these showed radiological tumor progression at ECS diagnosis. Twenty-one patients had multiple hormone secretion, which correlated with shorter overall survival (OS), p = 0.012 (HR 2.4 (95% CI 1.2–4.9)), as did high morning cortisol, p = 0.037 (HR 2.3 (1.0–5.2)), higher tumor grade, p = 0.044 (HR 2.3 (1.0–5.1)), and diabetes, p = 0.050 (HR 2.4 (1.0–6.0)).

Conclusions
Multiple hormone secretion, high morning cortisol, higher tumor grade, and diabetes were correlated with shorter OS. Development of ECS in patients with a non-functioning NEN may indicate tumor progression. Multiple hormone secretion should be considered as a bad prognostic sign in ECS patients and should lead to intensified clinical management.