bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ege Üniversitesi Hastanesinde erkek genital sistem kanserlerinin epidemiyolojik ve genel sağ kalım özellikleri
Authors: HAYDAROĞLU Ayfer , YALMAN Deniz , ÖZKÖK Serdar , GÖKMEN Erhan , ŞEN Sait , SARSIK KUMBARACI Banu , KIZILAY Fuat , CÜREKLİBATIR İbrahim , CANER Ayşe 
Published: January 2020

Amaç: Ege Üniversitesi Hastanesi’nde (EÜH) Erkek Genital Sistem Kanseri (EGSK) tanısı ile tedavileri yapılan 5.634 kayıtlı olgunun epidemiyolojik ve genel sağ kalım (GSK) özelliklerini istatistiksel açıdan değerlendirmektir.
Gereç ve Yöntem: Sınıflandırmalarda ve sağ kalım analizlerinde “Surveillance, Epidemiology, and End Results” (SEER) verileri göz önüne alınmıştır. CANREG-4 programı ile kaydedilen veriler SPSS programına aktarılmıştır. İstatistik analizde Ki-kare yöntemi ve doğrusal modellemeler yapılmış ve p
Neuropsychological Profile, Cognitive Reserve and Emotional Distress in a Portuguese Sample of Severely Obese Patients
Authors: Ribeiro Olga , Carmo Isabel do , Paiva Teresa , Figueira Maria Luísa 
Published: January 2020

Introduction: Obesity is a significant risk factor for multiple comorbidities, and its relation to neurocognitive disfunction is particularly important in cognitive decline, especially in middle age. Due to their impact on neurodegeneration, we sought to explore neuropsychological profile, cognitive reserve and emotional distress in patients with severe obesity.Material and Methods: We used a sociodemographic and clinical questionnaire, neuropsychological tests and a symptom self-reported scale of emotional distress. We evaluated the cognitive performance of 120 patients, aged between 18 and 65 years, in treatment for their severe obesity in Portugal, between May 2012 and December 2015.Results: Cognitive performance was below the mean for the Portuguese population, for immediate recall, visuoperception, resistance to interference and cognitive flexibility. Cognitive reserve was mostly low, especially in the older groups and groups with low professional status and increased associated with better cognitive outcomes. Emotional distress was shown to be higher in our sample compared with a normative sample. The risk factors evaluated were important in the worsening of cognitive functions. Cognitive performance decreased with age.Discussion: Severe obesity was associated with a poorer cognitive performance of the sample. The cognitive reserve was greater in the younger groups. There was a significant presence of emotional distress, especially among women.Conclusion: Severe obesity is associated with an impairment in cognitive and emotional performance, aggravated by aging, cognitive reserve, and comorbidity. This study emphasizes the need for preventive actions, such as neuropsychological screening, in the detection of changes and the design of better interventions.
Humerus Fractures After Open Subpectoral Biceps Tenodesis
Authors: Erdle Nicholas J. , Osier Charles J. , Hammond James E. 
Published: January 2020

Case:
The authors present 3 cases of humerus fracture after biceps tenodesis performed by 3 different surgeons with radiographs and outcome scores with a minimum of 30 months follow-up. Fractures occurred between 7 days and 4 months postoperatively and include 2 fractures where tenodesis had been performed with interference screw fixation and one fracture where tenodesis had been performed with a bicortical endobutton technique.

Conclusions:
These case reports highlight the risk of this complication in biceps tenodesis with bony fixation. The authors review the previously reported cases and relevant biomechanical studies that elucidate risk factors for humerus fracture and discuss alternative means to treat biceps tendon pathology.
Rotator Cuff Retears
Authors: Rossi Luciano Andrés , Chahla Jorge , Verma Nikhil N. , Millett Peter J. , Ranalletta Maximiliano 
Published: January 2020

» Regardless of recent advances in rotator cuff repair techniques, the rate of unhealed or recurrent rotator cuff tears remains high, with most recurrent rotator cuff tears occurring within the first 6 months after surgery.» Factors that can negatively affect tendon healing include older age, greater tear size, tendon retraction, and fatty infiltration. However, several clinical features that are often underestimated, including osteoporosis, diabetes, smoking, and hyperlipidemia, have proven to have an important influence on rotator cuff healing.» Recent meta-analyses that evaluated studies with Level-I and Level-II evidence have shown an overall increase in retear rates after single-row repair compared with double-row repair. However, to our knowledge, there are no Level-I clinical studies comparing different double-row configurations and, to date, no double-row repair technique has proven to be superior to the others.» The influence of postoperative rotator cuff healing on clinical outcomes is controversial. Although clinical differences may not be apparent in the short term, healed tendons have had better functional outcomes and greater strength in the midterm.» In general, a period of immobilization for 2 to 4 weeks, depending on tear size, is recommended. Graded supervised rehabilitation has proven to facilitate tendon healing without associated stiffness compared with early unprotected range of motion.
Opinie położnych na temat planowanego porodu odbywanego w warunkach pozaszpitalnych*
Authors: Fryc Dorota , Bielicka Anna , Ćwiek Dorota , Szymoniak Katarzyna , Daszkiewicz Agata 
Published: January 2020

ABSTRACTIntroduction: According to the Nurses and Midwives Act and other legal Acts, a midwife is a person having appropriate competence for independent care of a woman during physiological pregnancy, childbirth and the postpartum period, and a newborn. These entitlements do not only apply to practice in a hospital or clinic, but also to home conditions, including physiological delivery in locations other than a hospital.The aim of the study is to know the opinion of midwives on planned births in non-hospital locations.Materials and methods: 233 midwives from all over Poland were surveyed. The survey was conducted between May and August 2014. The diagnostic survey method was applied using the author’s questionnaire. Statistica 10 and MS Office programs were used for statistical analysis.Results: 22.1% of the surveyed midwives expressed a willingness to attend a home birth. 67.1% of respondents would not attend a home birth. The decision to attend a birth in non-clinical setting was significantly dependent on the safety of such a birth (p = 0.0000).Conclusions: There was a statistically significant relationship between the opinion of the respondents on the safety of out-of-hospital birth setting and possible handling of such labors.
Obciążenie opiekunów nieformalnych a sprawność funkcjonalna i umysłowa pacjentów objętych opieką domową
Authors: Deluga Alina , Bartoszek Agnieszka , Ślusarska Barbara , Kocka Katarzyna , Nowicki Grzegorz , Piasecka Katarzyna , Kachaniuk Hanna 
Published: January 2020

ABSTRACTIntroduction: Family members as informal caregivers are the most common and important providers of caring services in the home environment of patients suffering from chronic diseases.The aim of the study was to assess the relationship between the functional and mental performance of patients being provided long-term nursing home care and the burden of their caregivers.Materials and methods: The study was carried out in the Lublin region from September 2016 to February 2017. The study group included 149 patients with chronic diseases under long-term nursing home care and their 150 informal caregivers. The burden of the caregivers was assessed by means of the Carers of Older People in Europe (COPE) Index questionnaire which is used to check different aspects of the caregivers’ roles, life situations and relationships with the care recipients. The patients’ functional performance was measured by means of the Barthel Index for Activities of Daily Living, while their mental performance was checked using the Abbreviated Mental Test Score.Results: According to the COPE Index, the caregivers’ burden for particular subscales was as follows: Negative Influence of Care (NIC) 11.80 (SD = 3.75), Positive Value of Care (PVC) 13.71 (SD = 2.07), Quality of Support (QS) 12.46 (SD = 2.69). It has been indicated that the worse the functional and mental performance of the patient under care, the greater the burden of the carers – NIC (p < 0.01), the lower the satisfaction with care – PVC (p < 0.01) and the lower the quality of support given – QS (p < 0.01). The deterioration of a patient’s mental performance correlates with the female gender of the caregiver and the longer duration of care.Conclusions: The lower functional and mental performance of patients who are being provided long-term nursing home care has a relationship to the experience of the negative effects of care by informal carers, lower satisfaction with care and lower quality of support.
Wpływ muzyki popularnej na odbiór emocjonalny materiału obrazowego u młodzieży gimnazjalnej
Authors: Chęć Magdalena , Ligocka Maria , Łodygowska Ewa , Samochowiec Jerzy , Samochowiec Agnieszka 
Published: January 2020

ABSTRACTIntroduction: Among adolescents, the importance of music reveals itself in their subjective experience (feelings), expression and emotional behaviors, as well as their physiological reactions. Music is of particular value because it is accepted and liked by young people, it stimulates imagination, provides many aesthetic impressions and has a significant impact onthe personal experience of the listeners. Adolescents have their own preferences regarding music, conditioned by their personality or situational factors.The primary purpose of this study is to determine the impact of different genres of music on experiencing emotions by young people.Materials and methods: In the project we assumed that the effect of music depends on many factors, such as its genre and the age or gender of the listener. We argue that listening topopular music causes changes in teenagers’ emotions, the music genre determines the nature of invoked emotions and that gender differentiates perception of emotions depending onthe kind of music one is listening to. We conducted a psychological experiment with a questionnaire to assess the participants’ initial mood, upon which they were presented with athree minute music video (hip-hop, pop, or heavy metal, depending on the group) and asked to evaluate 21 IAPS pictures (The International Affective Picture System), then they filled out a self-designed questionnaire including questions on demographic data, music preferences, or potential hearing problems. The study involved 388 second and third-grade secondary school students from Szczecin.Results: The experiment permitted identifying the cause and effect relationship between listening to music and emotions of the youth. It has been shown that in adolescents, listening to popular music evokes changes within emotions. These changes have more negative than positive effects on young people’s emotional reception of reality. In adolescents, gender has a differentiating function in the emotional reception of visual stimuli while listening to music.Conclusions: The experiment results show that listening to a specific music genre during the period of adolescence can have an important and specific role in development and socio-emotional functioning, and also indicates the need for further research on this issue.
Non-replication of an association between theOdd-skipped related 1c.654G>A (rs12329305) polymorphism and kidney volume in newborns
Authors: Kaczmarczyk Mariusz , Łoniewska Beata , Kuprjanowicz Anna , Boroń Agnieszka , Gorący Iwona , Ryder Małgorzata , Taryma-Leśniak Olga , Ciechanowicz Andrzej 
Published: January 2020

AbstractIntroduction: Odd-skipped related 1 (Osr1) protein is a marker of intermediate mesoderm from which all definitive kidney progenitor cells develop. The loss-of-functionOSR1c.654G>A (rs12329305) polymorphism has been associated with a reduced kidney volume at birth and congenital renal anomalies.The aim of this study was to re-investigate whether theOSR1c.654A allele is associated with a smaller kidney volume (a surrogate of the congenital nephron number) in newborns, either alone or in combination withRETc.1296G>A(RETxOSR1interaction).Materials and methods: A total of 178 healthy, full-term Polish newborns were included in this study. Kidney size was measured by ultrasound on the third day of life and normalised for body surface area (TKV/BSA). TheOSR1polymorphism was identified by mini-sequencing. The reduced model without interaction and the full model including interaction terms were compared using the F test.Results: TKV/BSA did not differ across the genotype groups, t(176) = −0.45, p = 0.653 (106 ±24 and 108 ±25 mL/m2 for GG and GA, respectively). Similarly, there was no effect of the c.654G>A geno-type on TKV/BSA after controlling for the effect of covariates, F(1,175) = 0.28, p = 0.598. There was no association of theRETxOSR1interaction on the TKV/BSA.Conclusion: We did not find an association between theOSR1c.1296G> A polymorphism, alone and in combination withRETc.645G> A and kidney size in a group of healthy full-term newborns.
Adenosine receptors as therapeutic targets for the treatment of myocardial infarction and its complications. Part I. Myocardial infarction
Authors: Puchałowicz Kamila , Safranow Krzysztof , Rać Monika , Chlubek Dariusz , Dziedziejko Violetta 
Published: January 2020

Abstract
Adenosine is an endogenous compound with cardioprotective properties that acts via A1, A2A, A2B and A3 plasma membrane receptors. Over the last several decades, the mechanisms underlying adenosine’s protective effects in the ischemic myocardium were investigated. They are the basis for ischemic preconditioning and postconditioning procedures that protect the heart from ischemia/reperfusion injury. The promising results of animal model studies have encouraged a large group of researchers to conduct clinical trials assessing the benefits of adenosine as an adjunct to reperfusion therapy in myocardial infarction. This review describes the mechanisms behind the cardioprotective effect of adenosine and presents current reports on its clinical utility in the treatment of myocardial infarction.
HPV infections in head and neck cancers (HNSCC) – clinical course and efficiency of therapy
Authors: Sikora Mateusz , Przesławska Magda , Becht Rafał 
Published: January 2020

Abstract
Head and neck cancers represent a heterogenous group of neoplasms. Among them, the most frequently occurring is squamous cell carcinoma. Risk factors that can contribute to the development of head and neck cancers are smoking, high proof alcohol abuse and human papilloma virus (HPV) infection. Head and neck cancers may be divided into HPV positive and HPV negative. This division shows the different landscape of carcinogen-esis, median age of onset, etiopathogenesis, clinical course and treatment efficiency. Head and neck squamous cell carcinoma (HNSCC), especially HPV positive, belongs to highly immunogenic cancers. Its development relates to HPV infection and host immune response, especially with T regulatory lymphocytes response. Programmed cell death protein-1 (PD-1), which shows immunosuppressive effect on host’s immune system, takes part in cancerogenesis. That favours carcinogenesis. The development of immuno-oncology and better understanding of HNSCC pathogenesis has contributed to developments in immunotherapy, a method of care which is used preferably in the treatment of advanced, refractory or relapsed cancers that did not respond to standard-of care cancer treatments – in the case of HNSCC it is surgical resection with possible radiochemotherapy or chemotherapy. The idea of immunotherapy is to remove tumor immunosuppressive effect and to boost host immune response to eliminate neoplasm.
This article shows a review of current knowledge and new methods of therapy concerned with HNSCC treatment, especially HPV positive HNSCC.
Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana
Authors: Smith-Togobo Cecilia , Pedersen Mette Ø , Jensen Steffen G , Duduyemi Babatunde , Gyasi Richard K , Ofori Michael F , Paintsil Vivian , Renner Lorna , Nørgaard Peter , Hviid Lars 
Published: January 2020

AbstractEndemic Burkitt lymphoma (eBL) is an aggressive B-cell lymphoma, which is a common childhood cancer in areas with intense transmission of Plasmodium falciparum parasites. Early and accurate diagnosis is a prerequisite for successful therapy, but it optimally involves advanced laboratory investigations. These are technologically demanding, expensive, and often difficult to implement in settings where eBL is prevalent. Diagnosis is thus generally based on clinical assessment and morphological examination of tumour biopsies or fine-needle aspirates (FNAs). The purpose of the present study was to assess the accuracy of eBL diagnosis at two tertiary hospitals in Ghana. To that end, we studied FNAs from 29 eBL patients and 21 non-eBL lymphoma patients originally diagnosed in 2018. In addition, we examined 111 archival formalin-fixed and paraffin-embedded (FFPE) biopsies from Ghanaian patients originally diagnosed as eBL (N=55) or non-eBL (N=56) between 2010 and 2017. Availability-based subsets of samples were subjected to haematoxylin-eosin or Giemsa staining, C-MYC immunohistochemistry, and fluorescence in situ hybridisation (FISH) analysis of c-myc rearrangements We found a good correlation between original diagnosis and subsequent retrospective assessment, particularly for FNA samples. However, evidence of intact c-myc genes and normal C-MYC expression in samples from some patients originally diagnosed as eBL indicates that morphological assessment alone can lead to eBL over-diagnosis in our study area. In addition, several FFPE samples could not be assessed retrospectively, due to poor sample quality. Therefore, the simpler FNA method of obtaining tumour material is preferable, particularly when careful processing of biopsy specimens cannot be guaranteed. We conclude that the accuracy of eBL diagnostic tools available in Ghana is generally adequate, but could be improved by implementation of additional pathology laboratory investigations. Improved attention to adequate preservation of archival samples is recommended.
The Association between Sleep Quality and Loneliness in Rural Elderly Individuals: A Cross-Sectional Study in Shandong Province, China
Authors: Jia Gaizhen , Yuan Ping 
Published: January 2020

Abstract

Background: There is evidence of negative associations between loneliness and sleep quality in older adults. However, little is known regarding the relationship between loneliness and sleep quality among Chinese rural elderly. This study examined the associations of loneliness and sleep quality in a cross-sectional study of older adults. Methods: A face-to-face questionnaire survey was conducted among 1,568 rural elderly people in Shandong Province, China. Loneliness was assessed using the University of California at Los Angeles Loneliness Scale. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Ordinal logistic regression was conducted to examine the association of loneliness and sleep quality after adjusting for multiple confounding variables. Results: After controlling for variables such as age, marriage, education, occupation, economic income, family relationships, living arrangement, smoking, drinking, chronic diseases, quality of life in a multivariable analysis, poor sleep quality still indicates loneliness in the rural elderly population. Conclusion: This finding implied an adverse effect of sleep quality on the loneliness of older adults. Poor sleep quality was associated with the increased odds of loneliness in Chinese rural older adults. Sleep-based interventions should be developed to prevent loneliness in rural older adults in China.
A novel five-gene signature for predicting prognosis in liver cancer
Authors: Zhong Qiuyue , Shuai Yu , Luo Qiong , Feng Guangyong , Wu Mingna , Fan Erxi , Chen Qiying , Yue Guojun , Zhang Guihai 
Published: January 2020

Abstract
Purpose Liver cancer is one of the most common malignant tumors in China, ranked 5th among the malignant common tumors in the world, which is still difficult to diagnose early and treat effectively. Therefore, exploring some indicators for prognostic prediction is imperative in the treatment of liver cancer. Methods Liver cancer data was obtained from The Cancer Genome Atlas (TCGA). We obtained differentially expressed genes (DEGs) by R software from TCGA database. Risk scores were acquired to assess the weighted gene-expression levels by Cox regression analysis and predict the prognosis of patients with liver cancer. Using the KEGG and GO databases, pathway enrichment was performed by identifying the analysis of DEGs. The display of receiver-operating characteristic (ROC) curves and area under the curve (AUC) could show the validity and the prognostic value of this model in liver cancer. Results In total, 1897 DEGs of transcriptome genes in liver cancer and 1197 DEGs of clinical data were extracted from the TCGA database. We identified a novel five-gene signature associated with liver cancer, including CDCA8, NR0B1, GAGE2A, AC018641.1, and SPANXC. Among of them, CDCA8 and NR0B1 were negatively related to 5-year OS, displaying a worse prognosis (P < 0.05). In particular, we also found that GAGE2A is related to lymphatic metastasis from the clinical data analysis in liver cancer. Receiver-operating characteristic (ROC) curve assessed the accuracy and sensitivity of the gene signature. In the heat map, each of the five genes for patients was presented with the distribution of the risk score. Conclusions We figured out a novel five-gene signature for the prognosis of patients with liver cancer, which may be an effective predictor for patients’ prognosis in the future.
Early veno arterial PCO2 difference is associated with outcome in peripheral veno arterial extracorporeal membrane oxygenation
Authors: Ellouze Omar , Nguyen Maxime , Missaoui Anis , Radhouani Mohamed , Berthoud Vivien , Aho Serge , Bouchot Olivier , Guinot Pierre Grégoire , Bouhemad Belaid 
Published: January 2020

Abstract
Background: Veno arterial membrane oxygenation (VA ECMO) is increasingly used for cardiogenic failure. However, hemodynamic targets for adequate resuscitation remain a challenge. The PCO 2 gap and the ratio between PCO 2 gap and the arteriovenous difference in oxygen (PCO 2 gap/Da–vO 2 ) are marker of peripheral hypoperfusion. We hypothesized that the PCO 2 gap and the PCO 2 gap/Da–vO 2 ratio might be useful parameters in VA ECMO patients.
Methods: We conducted an observational prospective study between September 2015 and February 2017. All consecutive patients >18 years of age who had been treated with peripheral VA ECMO for cardiac failure were included. We compared 2 groups of patients: patients who died of any cause under VA ECMO or in the 72h following VA ECMO weaning (early death group) - and patients who survived VA ECMO weaning more than 72h (surviving group). Blood samples were drawn from arterial and venous VA ECMO cannulas at H0 and H6. The ability of PCO 2 gap and PCO 2 gap/Da–vO 2 to discriminate between early mortality and surviving was studied using ROC curves analysis.
Results: We included 20 patients in surviving group and 29 in early death group. The PCO 2 gap was higher in the early death group at H6 (7.4 [5.7–10.1] vs. 5.9 [3.8–9.2], p < 0.01). AUC for PCO 2 gap at H6 was 0.76 (0.61–0.92), with a cut-off of 6.2 mmHg. The PCO 2 gap/Da–vO 2 was higher in the early death group at H0 (2.1 [1.5–2.6] vs. 1.2 [0.9–2.4], p < 0.01) and at H6 (2.1 [1.3–2.6] vs. 1.0 [0.8–1.7], p < 0.01). AUC for PCO 2 gap/Da–vO 2 at H0 and H6 were 0.79 and 0.73 respectively; the cut-off value was 1.4.
Conclusions: The PCO 2 gap and the PCO 2 gap/Da–vO2 ratio are associated with early death in patients who undergo VA ECMO.