bluuebunny/crossref_metadata_2025_split huggingface dataset:
A geothermal aquifer in the dilation zones on the southern margin of the Dublin Basin
Authors: Vozar Jan , Jones Alan G , Campanya Joan , Yeomans Chris , Muller Mark R , Pasquali Riccardo 
Published: November 2019

SUMMARYWe present modelling of the geophysical data from the Newcastle area, west of Dublin, Ireland within the framework of the IRETHERM project. IRETHERM's overarching objective was to facilitate a more thorough strategic understanding of Ireland's geothermal energy potential through integrated modelling of new and existing geophysical, geochemical and geological data. The Newcastle area, one of the target localities, is situated at the southern margin of the Dublin Basin, close to the largest conurbation on the island of Ireland in the City of Dublin and surrounds. As part of IRETHERM, magnetotelluric (MT) soundings were carried out in the highly urbanized Dublin suburb in 2011 and 2012, and a description of MT data acquisition, processing methods, multidimensional geoelectrical models and porosity modelling with other geophysical data are presented. The MT time-series were heavily noise-contaminated and distorted due to electromagnetic noise from nearby industry and Dublin City tram/railway systems. Time-series processing was performed using several modern robust codes to obtain reasonably reliable and interpretable MT impedance and geomagnetic transfer function ‘tipper’ estimates at most of the survey locations. The most ‘quiet’ 3-hr subsets of data during the night time, when the DC ‘LUAS’ tram system was not operating, were used in multisite and multivariate processing. The final 2-D models underwent examination using a stability technique, and the final two 2-D profiles, with reliability estimations expressed through conductance and resistivity, were derived. In the final stage of this study, 3-D modelling of all MT data in the Newcastle area was also undertaken. Comparison of the MT models and their interpretation with existing seismic profiles in the area reveals that the Blackrock–Newcastle Fault (BNF) zone is visible in the models as a conductive feature down to depths of 4 km. The investigated area below Newcastle can be divided into two domains of different depths, formed as depth zones. The first zone, from the surface down to 1–2 km, is dominated by NE–SW oriented conductors connected with shallow faults or folds probably filled with less saline waters. The conductors are also crossing the surface trace of the BNF. The second depth domain can be identified from depths of 2–4 km, where structures are oriented along the BNF and the observed conductivity is lower. The deeper conductive layers are interpreted as geothermal-fluid-bearing rocks. Porosity and permeability estimations from the lithological borehole logs indicate the geothermal potential of the bedrock, to deliver warm water to the surface. The fluid permeability estimation, based on Archie's law for porous structures and synthetic studies of fractured zones, suggests a permeability in the range 100 mD–100 D in the study area, which is prospective for geothermal energy exploitation.
Colour maps for fisheries acoustic echograms
Authors: Blackwell Robert E , Harvey Richard , Queste Bastien Y , Fielding Sophie 
Published: November 2019

Abstract
Echograms are used to visualize fisheries acoustic data, but choice of colour map has a significant effect on appearance. Quantitative echograms should use colour maps, which are colourful (have a perceived variety and intensity of colours), sequential (have monotonic lightness), and perceptually uniform (have consistency of perceived colour contrast over their range). We measure whether colour maps are colourful (M^(3)&gt;0), sequential (rs=±1), and perceptually uniform (ρ = 1) using an approximately perceptually uniform colour space (CIELAB). Whilst all the fisheries acoustic colour maps tested are colourful, none is sequential or perceptually uniform. The widely used EK500 colour map is extremely colourful (M^(3)=186), not sequential (rs=0.06), and has highly uneven perceptual contrast over its range (ρ=0.26). Of the fisheries acoustic colour maps tested, the Large Scale Survey System default colour map is least colourful (M^(3)=79), but comes closest to being sequential (rs=−0.94), and perceptually uniform (ρ=0.95). Modern colour maps have been specifically designed for colour contrast consistency, accessibility for viewers with red-green colour-blindness, and legibility when printed in monochrome, and may be better suited to the presentation and interpretation of quantitative fisheries acoustic echograms.
In vitro study of trileaflet polytetrafluoroethylene conduit and its valve-in-valve transformation
Authors: Chang Te-I , Hsu Kang-Hong , Luo Chi-Wen , Yen Jen-Hong , Lu Po-Chien , Chang Chung-I 
Published: November 2019

Abstract

OBJECTIVES
Handmade trileaflet expanded polytetrafluoroethylene valved conduit developed using the flip-over method has been tailored for pulmonary valve reconstruction with satisfactory outcomes. We investigated the in vitro performance of the valve design in a mock circulatory system with various conduit sizes. In our study, the design was transformed into a transcatheter stent graft system which could fit in original valved conduits in a valve-in-valve fashion.

METHODS
Five different sizes of valved polytetrafluoroethylene vascular grafts (16, 18, 20, 22 and 24 mm) were mounted onto a mock circulatory system with a prism window for direct leaflets motion observation. Transvalvular pressure gradients were recorded using pressure transducers. Mean and instant flows were determined via a rotameter and a flowmeter. Similar flip-over trileaflet valve design was then carried out in 3 available stent graft sizes (23, 26 and 28.5 mm, Gore aortic extender), which were deployed inside the valved conduits.

RESULTS
Peak pressure gradient across 5 different sized graft valves, in their appropriate flow setting (2.0, 2.5 and 5.0 l/min), ranged from 4.7 to 13.2 mmHg. No significant valve regurgitation was noted (regurgitant fraction: 1.6–4.9%) in all valve sizes and combinations. Three sizes of the trileaflet-valved stent grafts were implanted in the 4 sizes of valved conduits except for the 16-mm conduit. Peak pressure gradient increase after valved-stent graft-in-valved-conduit setting was &lt;10 mmHg in all 4 conduits.

CONCLUSIONS
The study showed excellent in vitro performance of trileaflet polytetrafluoroethylene valved conduits. Its valved stent graft transformation provided data which may serve as a reference for transcatheter valve-in-valve research in the future.
Generalized Logarithmic Hardy–Littlewood–Sobolev Inequality
Authors: Dolbeault Jean , Li Xingyu 
Published: November 2019

Abstract
This paper is devoted to logarithmic Hardy–Littlewood–Sobolev inequalities in the 2D Euclidean space, in the presence of an external potential with logarithmic growth. The coupling with the potential introduces a new parameter, with two regimes. The attractive regime reflects the standard logarithmic Hardy–Littlewood–Sobolev inequality. The 2nd regime corresponds to a reverse inequality, with the opposite sign in the convolution term, which allows us to bound the free energy of a drift–diffusion–Poisson system from below. Our method is based on an extension of an entropy method proposed by E. Carlen, J. Carrillo, and M. Loss, and on a nonlinear diffusion equation.
Measuring quality and impact of telehealth services in home dialysis patients
Authors: Lew Susie Q 
Published: November 2019

Abstract
US Medicare beneficiaries receiving home dialysis will have the opportunity to engage in telehealth beginning in 2019. This new paradigm, if successful, will be instituted internationally. Any changes in healthcare delivery, such as using telehealth, will affect the process and quality. Quality of care metrics is discussed, and they can be used to evaluate the three domains of structure, process, and outcome when applied to assess telehealth’s impact and quality on the dialysis population.
Long-term follow-up of HIV-infected patients on dolutegravir monotherapy
Authors: Tebano G , Soulié C , Schneider L , Blanc C , Agher R , Seang S , Valantin M A , Palich R , Tubiana R , Peytavin G , Marcelin A G , Assoumou L , Katlama C 
Published: November 2019

Abstract

Background
In recent years, dolutegravir monotherapy has been explored as a drug-reduced regimen for HIV patients.

Methods
This was a retrospective observational study, including patients virologically suppressed for ≥6 months, without previous virological failure (VF) under integrase inhibitors (INIs), who had been switched to dolutegravir monotherapy (50 mg/day). The primary aim was to report the proportion of VF at week 48 (W48) and week 96 (W96) of dolutegravir monotherapy. The evolution from baseline to W48 of residual viraemia on ultra-deep sequencing and HIV DNA was also evaluated.

Results
Sixty-one patients were included. Prior to switching to dolutegravir monotherapy, they had a median (IQR) of 15.4 (6.5–19.9) years of antiretroviral exposure, 5.8 (3.2–10.3) years of viral suppression and 687 (461–848) CD4+ cells/mm3. They remained on dolutegravir monotherapy for a median (IQR) of 100 (29–148) weeks. Forty-two out of 61 patients (68.9%) reached W48 and 32 out of 61 patients (52.5%) reached W96. VF occurred in three patients, with the emergence of INI resistance. VF occurred before W24 and in patients pre-exposed to INIs. At W48, the probability of VF (Kaplan–Meier analysis) was 5.6% (95% CI = 1.8%–16.4%). The same result was obtained at W96. Detectable residual viraemia did not increase and median HIV DNA did not change significantly (2.4 log/106 cells at baseline and 2.3 log/106 cells at W48). Dolutegravir plasma concentration was above the IC90 in 41/41 samples, from 22 patients.

Conclusions
Long-term follow-up showed a low risk of VF under dolutegravir monotherapy, in a selected population of patients with previous long-term virological suppression and low HIV reservoir.
Understanding the nature and scope of clinical research commentaries in PubMed
Authors: Rogers James R , Mills Hollis , Grossman Lisa V , Goldstein Andrew , Weng Chunhua 
Published: November 2019

Abstract
Scientific commentaries are expected to play an important role in evidence appraisal, but it is unknown whether this expectation has been fulfilled. This study aims to better understand the role of scientific commentary in evidence appraisal. We queried PubMed for all clinical research articles with accompanying comments and extracted corresponding metadata. Five percent of clinical research studies (N = 130 629) received postpublication comments (N = 171 556), resulting in 178 882 comment–article pairings, with 90% published in the same journal. We obtained 5197 full-text comments for topic modeling and exploratory sentiment analysis. Topics were generally disease specific with only a few topics relevant to the appraisal of studies, which were highly prevalent in letters. Of a random sample of 518 full-text comments, 67% had a supportive tone. Based on our results, published commentary, with the exception of letters, most often highlight or endorse previous publications rather than serve as a prominent mechanism for critical appraisal.
Effect of dietary medium-chain fatty acids on nursery pig growth performance, fecal microbial composition, and mitigation properties against porcine epidemic diarrhea virus following storage
Authors: Gebhardt Jordan T , Thomson Katelyn A , Woodworth Jason C , Dritz Steve S , Tokach Michael D , DeRouchey Joel M , Goodband Robert D , Jones Cassandra K , Cochrane Roger A , Niederwerder Megan C , Fernando Samodha , Abbas Waseem , Burkey Thomas E 
Published: November 2019

AbstractAn experiment was conducted to evaluate the effect of dietary medium-chain fatty acid (MCFA) addition on nursery pig growth performance, fecal microbial composition, and mitigation of porcine epidemic diarrhea virus (PEDV) following storage. A total of 360 pigs (DNA 400 × 200, Columbus, NE; initially 6.7 ± 0.07 kg) were randomized to pens (5 pigs per pen) on the day of weaning (approximately 20 d of age), allowed a 6-d acclimation, blocked by BW, and randomized to dietary treatment (9 pens per treatment). All MCFA (Sigma–Aldrich, St. Louis, MO) were guaranteed ≥98% purity, including hexanoic (C6:0), octanoic (C8:0), and decanoic (C10:0) acids. Treatment diets were formulated in 2 phases (7 to 11 and 11 to 23 kg BW) and formulated to meet or exceed NRC requirement estimates. Treatments (n = 8) were a dose response including 0%, 0.25%, 0.5%, 1.0%, and 1.5% added MCFA blend (1:1:1 ratio C6:0, C8:0, and C10:0), as well as treatments with individual additions of 0.5% C6:0, C8:0, or C10:0. Fecal samples were collected from pigs fed control and 1.5% MCFA blend diets on days 0 and 14 and analyzed using 16s rDNA sequencing. Following feed manufacture, feed was stored in bags at barn temperature and humidity for 40 d before laboratory inoculation with PEDV. Subsamples of retained feed were inoculated with PEDV to achieve a titer of 104 TCID50/g and separate sample bottles were analyzed on 0 and 3 d post-inoculation (dpi). Overall, ADG and ADFI were increased (linear, P ≤ 0.010) and feed efficiency (G:F) improved (linear, P = 0.004) with increasing MCFA blend. Pigs fed 0.5% C8:0 had greater (P = 0.038) ADG compared with pigs fed the control diet, and G:F was improved (P ≤ 0.024) when pigs were fed 0.5% C6:0, 0.5% C8:0, or 0.5% C10:0 compared with control. An inclusion level × day interaction was observed (quadratic, P = 0.023), where PEDV Ct values increased (quadratic, P = 0.001) on 0 dpi with increasing levels of MCFA blend inclusion and also increased on 3 dpi (linear, P &lt; 0.001). Fecal microbial diversity and composition were similar between control and 1.5% MCFA blend. In summary, the use of MCFA in nursery pig diets improves growth performance, provides residual mitigation activity against PEDV, and does not significantly alter fecal microbial composition.
The Price of Inattention: Evidence from the Swedish Housing Market
Authors: Repetto Luca , Solís Alex 
Published: November 2019

AbstractDo behavioral biases affect prices in a high-stakes market? We study the role of left-digit bias in the purchase of an apartment. Left-digit bias is the failure to fully process digits after the first, perceiving prices just below a round number (such as $3.99) as cheaper than their round counterpart ($4). Apartments with asking prices just below round millions are sold at a 3%–5% higher final price after an auction. This effect appears not to be driven by differences in observables or in real estate agents’ behavior. Auctions for apartments listed just below round numbers are more competitive and attract more bidders and bids.
Reinforcement and the Proliferation of Species
Authors: Calabrese Gina M , Pfennig Karin S 
Published: November 2019

AbstractAdaptive radiations are characterized by the rapid proliferation of species. Explaining how adaptive radiations occur therefore depends, in part, on identifying how populations become reproductively isolated—and ultimately become different species. Such reproductive isolation could arise when populations adapting to novel niches experience selection to avoid interbreeding and, consequently, evolve mating traits that minimize such hybridization via the process of reinforcement. Here, we highlight that a downstream consequence of reinforcement is divergence of conspecific populations, and this further divergence can instigate species proliferation. Moreover, we evaluate when reinforcement will—and will not—promote species proliferation. Finally, we discuss empirical approaches to test what role, if any, reinforcement plays in species proliferation and, consequently, in adaptive radiation. To date, reinforcement’s downstream effects on species proliferation remain largely unknown and speculative. Because the ecological and evolutionary contexts in which adaptive radiations occur are conducive to reinforcement and its downstream consequences, adaptive radiations provide an ideal framework in which to evaluate reinforcement’s role in diversification.
Early Marriage in Iran: A Pragmatic Approach
Authors: Asghari Shamin 
Published: November 2019

AbstractThe international human rights system has identified any marriage before the age of 18 as forced marriage or a harmful traditional practice which should be eradicated mainly through legal reform. In many legal systems, the minimum age of marriage is still below 18. In Iran, girls can marry at the age of 13 and boys at the age of 15. Thus, the issue of early marriage has been a point of struggle between the international human rights system and Iran. What is lost in these mainly legal debates is the reality of early marriage. Those who advocate for the eradication of early marriage present a singular perception of such marriage as forced and harmful, while those who oppose the international approach in Iran merely focus on the Islamic roots of the current legislation. In practice, marriage is a complicated social construct. To address early marriage, one should analyse different causes and contexts that influence this institution and determine whether the negative consequences apply in all cases of early marriage. This article argues that the international human rights system should provide a context-sensitive response to early marriage. The human rights discourse is not the only setting for addressing early marriage. The general categorization of early marriage as a violation of human rights fails to recognize various factors that influence the timing of marriage, in particular girls’ agency. To effectively address early marriage in Iran, a multidisciplinary approach is necessary.
Negotiating Space for Queer-Identifying Young People in a Refugee Organization: Viability, Complexities and Tensions
Authors: Mahn Churnjeet , Milne Ej , Guzman Mayra , Ahmed Farhio 
Published: November 2019

Abstract
There is relative invisibility and silence around the presence, management and support of queer people in mainstream refugee organizations in the United Kingdom. Institutional silencing exists, particularly where visibility or acknowledgement has the potential to disrupt existing structures. At the same time, queer refugees face the risk of exclusion, and may also undertake self-censoring. Drawing on empirical data from an innovative, cross-disciplinary, community-based participatory research project between a United Kingdom-based refugee organization and two universities, this article explores the viability, complexities and tensions inherent in making queer identities visible. While highlighting the potential of arts-based methods to explore inclusive approaches to sexuality, we discuss the limits of this work and the resistance it created. This article is co-authored by members of RX—a collective of young people with refugee backgrounds; two community researchers; a humanities researcher; and a peace-studies researcher.
Integrative analysis of the nuclear proteome in Pinus radiata reveals thermopriming coupled to epigenetic regulation
Authors: Lamelas Laura , Valledor Luis , Escandón Mónica , Pinto Gloria , Cañal María Jesús , Meijón Mónica 
Published: November 2019

Abstract
Despite it being an important issue in the context of climate change, for most plant species it is not currently known how abiotic stresses affect nuclear proteomes and mediate memory effects. This study examines how Pinus radiata nuclei respond, adapt, ‘remember’, and ‘learn’ from heat stress. Seedlings were heat-stressed at 45 °C for 10 d and then allowed to recover. Nuclear proteins were isolated and quantified by nLC-MS/MS, the dynamics of tissue DNA methylation were examined, and the potential acquired memory was analysed in recovered plants. In an additional experiment, the expression of key gene genes was also quantified. Specific nuclear heat-responsive proteins were identified, and their biological roles were evaluated using a systems biology approach. In addition to heat-shock proteins, several clusters involved in regulation processes were discovered, such as epigenomic-driven gene regulation, some transcription factors, and a variety of RNA-associated functions. Nuclei exhibited differential proteome profiles across the phases of the experiment, with histone H2A and methyl cycle enzymes in particular being accumulated in the recovery step. A thermopriming effect was possibly linked to H2A abundance and over-accumulation of spliceosome elements in recovered P. radiata plants. The results suggest that epigenetic mechanisms play a key role in heat-stress tolerance and priming mechanisms.
Sacramental Vision in Annie Dillard’s Holy the Firm
Authors: Matheson Rachel 
Published: November 2019

Abstract
In this article I explore the central motif of vision in Annie Dillard’s short poetic narrative, Holy the Firm. Attention to the book’s tripartite structure reveals a movement through an aesthetic appreciation of creation, to an intellectual contemplation of the Fall, finally culminating in a mystical vision of wholeness in the redemptive descent of Christ. I turn to Julian of Norwich’s parable of the Lord and Servant in order to illuminate their shared attunement to the workings of divine love in the face of human suffering. For Dillard, Christ’s kenotic love is continually revealed in the Christian sacraments of baptism and communion. Finally, I suggest that through the artist, the thinker, and the nun, Dillard leads her reader toward a sacramental vision of the world, which locates the holy in the everyday.
Cool white dwarfs as standards for infrared observations
Authors: Gentile Fusillo Nicola Pietro , Tremblay Pier-Emmanuel , Bohlin Ralph C , Deustua Susana E , Kalirai Jason S 
Published: November 2019

ABSTRACT
In the era of modern digital sky surveys, uncertainties in the flux of stellar standards are commonly the dominant systematic error in photometric calibration and can often affect the results of higher level experiments. The Hubble Space Telescope (HST) spectrophotometry, which is based on computed model atmospheres for three hot (Teff$\gt 30\, 000$ K) pure hydrogen (DA) white dwarfs, is currently considered the most reliable and internally consistent flux calibration. However, many next-generation facilities (e.g. Harmoni on E-ELT, Euclid, and JWST) will focus on IR observations, a regime in which white dwarf calibration has not yet been robustly tested. Cool DA white dwarfs have energy distributions that peak close to the optical or near-infrared, do not have shortcomings from UV metal line blanketing, and have a reasonably large sky density (≃4 deg−2 at G &lt; 20), making them, potentially, excellent calibrators. Here, we present a pilot study based on STIS + WFC3 observations of two bright DA white dwarfs to test whether targets cooler than current hot primary standards (Teff$\lt 20\, 000$ K) are consistent with the HST flux scale. We also test the robustness of white dwarf models in the IR regime from an X-shooter analysis of Paschen lines and by cross-matching our previously derived Gaia white dwarf catalogue with observations obtained with 2MASS, UKIDSS, VHS, and WISE.