bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry method for determining apremilast in beagle dog plasma and urine: Application in a pharmacokinetic study
Authors: Yan Genquan , Yu Lu , Chen Xu , Tran Triet , Nguyen Lam , Wang Zhijun , Wang Ling 
Published: May 2020

AbstractA rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC/MS/MS) method for determining apremilast in beagle dog plasma and urine samples was developed and validated using clopidogrel as the internal standard (IS). Apremilast was extracted from the plasma and urine samples by liquid–liquid extraction using methyl tert-butyl ether. Chromatographic separation was performed using a C8 column with gradient elution and a mobile phase containing methanol and 0.1% formic acid. Quantification was achieved in multiple reaction monitoring (MRM) mode with a transition of m/z 461.3→178.2 for apremilast and m/z 322.2→184.1 for clopidogrel (IS). This method was validated regarding its specificity, linearity, precision, accuracy, and stability. The lower limit of quantification (LLOQ) for this method was 5 ng/mL, and the calibration curve was linear over 5–1,000 ng/mL. The intra- and inter-run coefficients of variance (CV) of aprelimast in plasma samples were less than 12.92% and 10.64%, respectively, while in urine samples, the CV were less than 11.84% and 10.20%, respectively. The samples were stable under the tested conditions. This method was successfully applied to a pharmacokinetic study in beagle dogs following oral administration of 10 mg of apremilast.
A nagyérvasculitisek képalkotó vizsgálatának lehetőségei és azok jelentősége
Authors: Kolossváry Endre , Balázs György , Dósa Edit , Moravszki Mónika , Járai Zoltán , Farkas Katalin 
Published: May 2020

Absztrakt:
A Chapel Hill-i Konszenzuskonferencia által megfogalmazott beosztás szerint az
óriássejtes arteritis és a Takayasu-arteritis tartozik a nagyérvasculitisek
csoportjába. E kórállapotok felismerése döntően a klinikai kép értékelésén,
valamint a különböző vascularis képalkotó módszerek alkalmazásán alapul. Az
utóbbi lehetőséggel kapcsolatban az elmúlt években jelentős technológiai
fejlődés figyelhető meg, amely már nemcsak a diagnózis felállítását, hanem a
betegség kiterjedtségének és az érfali gyulladás fokának a megítélését is
lehetővé teszi. Ezenfelül az érfali gyulladás későbbi szövődményeinek
felismerése is lehetővé válik. Az ultrahang, a komputertomográfia és a
mágnesesrezonancia-vizsgálat, valamint a pozitronemissziós tomográfia képviselik
azokat a képalkotó modalitásokat, amelyek a bennük rejlő lehetőségek miatt
elengedhetetlenek az érintett betegek felismeréséhez, valamint hatékony
kezelésük és követésük tervezéséhez. Az ismeretek összefoglalása számos, az
érintett betegek gondozásában potenciálisan érintett szakterület érdeklődésére
tarthat számot. Orv Hetil. 2020; 161(23): 939–950.
Relationship between gestational weight gain and amount of postpartum bleeding
Authors: KINAY Tuğba , ÖZELÇİ Runa , DİLBAZ Berna , KAHYAOĞLU İnci , MORALOĞLU TEKİN Özlem 
Published: May 2020

AbstractBackground/Aims:To evaluate the effect of gestational weight gain on the amount of postpartum
bleeding.Methods: An observational study reviewed medical records of with low-risk
singleton pregnancies who delivered vaginally at 37 weeks of gestation or
beyond between May 1 and November 1, 2018 at a tertiary referral center. Demographic
and clinical characteristics were obtained from the medical records. The relationship
between the increased rate in BMI during pregnancy and amount of blood loss in
the postpartum first hour was evaluated. Results:A total of 411 women was included in the study. In the study population,
the mean blood loss was 57.3±43.9 ml in the 3rd stage of labor and
113.2±76.9 ml in the postpartum first hour. No correlation was found between
the increase in BMI during pregnancy and blood loss during the 3rd stage
of labor (r=0.006) and postpartum first hour (r=0.037). Nulliparity, history of
postpartum hemorrhage in previous pregnancy, premature rupture of membranes, and
episiotomy were found to be risk factors for increased postpartum blood loss during
the 1st hour (p&lt; 0.05). Conclusions: Increase in BMI was not related with the amount
of postpartum bleeding in women with low-risk pregnancy who had a vaginal
delivery.
Association between the regional variation in premature mortality and immigration in Ontario, Canada
Authors: Rosella Laura C. , Kornas Kathy , Watson Tristan , Buajitti Emmalin , Bornbaum Catherine , Henry David , Brown Adalsteinn 
Published: May 2020

Abstract
Objectives
Health region differences in immigration patterns and premature mortality rates exist in Ontario, Canada. This study used linked population-based databases to describe the regional proportion of immigrants in the context of provincial health region variation in premature mortality.

Methods
We analyzed all adult premature deaths in Ontario from 1992 to 2012 using linked population files, Canadian census, and death registry databases. Geographic boundaries were analyzed according to 14 health service regions, known as Local Health Integration Networks (LHINs). We assessed the role of immigrant status and regional proportion of immigrants in the context of these health region variations and assessed the contribution using sex-specific multilevel negative binomial models, accounting for age, individual- and area-level immigration, and area-level material deprivation.

Results
We observed significant premature mortality variation among health service regions in Ontario between 1992 and 2012. Average annual rates ranged across LHINs from 3.03 to 6.40 per 1000 among males and 2.04 to 3.98 per 1000 among females. The median rate ratio (RR) decreased for men from 1.14 (95% CI 1.06, 1.19) to 1.07 (95% CI 1.00, 1.11) after adjusting for year, age, area-based material deprivation, and individual- and area-level immigration, and among females reduced from 1.13 (95% CI 1.05, 1.18) to 1.04 (95% CI 1.00, 1.05). These adjustments explained 84.1% and 94.4% of the LHIN-level variation in males and females respectively. Reduced premature mortality rates were associated with immigrants compared with those for long-term residents in the fully adjusted models for both males 0.43 (95% CI 0.42, 0.44) and females 0.45 (0.44, 0.46).

Conclusion
The findings demonstrate that health region differences in premature mortality in Ontario are in part explained by individual-level effects associated with the health advantage of immigrants, as well as contextual area-level effects that are associated with regional differences in the immigrant population. These factors should be considered in addition to health system factors when looking at health region variation in premature deaths.
Toward Global Earthquake Early Warning with the MyShake Smartphone Seismic Network, Part 1: Simulation Platform and Detection Algorithm
Authors: Kong Qingkai , Martin-Short Robert , Allen Richard M. 
Published: May 2020

Abstract
The MyShake project aims to build a global smartphone seismic network to facilitate large-scale earthquake early warning and other applications by leveraging the power of crowdsourcing. The MyShake mobile application first detects earthquake shaking on a single phone. The earthquake is then confirmed on the MyShake servers using a “network detection” algorithm that is activated by multiple single-phone detections. In this part one of the two article series, we present a simulation platform and a network detection algorithm to test earthquake scenarios at various locations around the world. The proposed network detection algorithm is built on the classic density-based spatial clustering of applications with noise spatial clustering algorithm, with modifications to take temporal characteristics into account and the association of new triggers. We test our network detection algorithm using real data recorded by MyShake users during the 4 January 2018 M 4.4 Berkeley and the 10 June 2016 M 5.2 Borrego Springs earthquakes to demonstrate the system’s utility. In order to test the entire detection procedure and to understand the first order performance of MyShake in various locations around the world representing different population and tectonic characteristics, we then present a software platform that can simulate earthquake triggers in hypothetical MyShake networks. Part two of this paper series explores our MyShake early warning simulation performance in selected regions around the world.
Fault diagnosis and maintenance of automobile engine cooling system
Authors: Chen Chunmei 
Published: May 2020

With the further development of the society, the economic level of Chinese residents is gradually improving. Under such circumstances, the number of automobiles and their usage are increasing as well. As a kind of mechanical equipment, there will be many application faults of the automobile after long-term use. Only by solving the faults can automobiles be restarted and run stably for a long time. Based on this, this paper focuses on automobile maintenance, analyzes the principle of engine cooling system, and studies the diagnosis and maintenance methods of this kind of fault, trying to provide some reference value for the further discussion and research in this field.
Management of impacted maxillary central incisor by using TADs in different methods
Authors: Alasmari Ahmed , Aldhaheri Nadia , Altamimi Tawfeq , Altuwairqi Rabab , Bin Salamah Fahad 
Published: May 2020

Impaction of maxillary central incisor is one of the challenging cases in orthodontic clinics. Proper diagnosis and application of orthodontic biomechanics can limit the number of prosthetic and surgical intervention when treating maxillary central incisor impaction..
Observation on the therapeutic effect of glucocorticoid in severe pneumonia
Authors: Hu Wenping 
Published: May 2020

<p><strong>Objective:</strong> To observe the effect of glucocorticoid in severe pneumonia. <strong>Methods:</strong> 72 patients with severe pneumonia who were admitted to the ICU department of Ji'an city central people's hospital of Jiangxi province from January 2018 to January 2019 were treated by computer table method. Among them, 36 patients were included in the control group, and the rest 36 were included in the observation group. <strong>Results:</strong> The time cost of the observation group was less than that of the control group, P &lt; 0.05. Conclusion: The combination of glucocorticoid in the treatment of severe pneumonia is more beneficial to the recovery of patients and reduces the time of suffering.</p>
The Characteristics of Hierarchy of Self-Image Components Depending on Social And Cultural Affiliation
Authors: Yanitskiy M , Seryy A , Braun O 
Published: May 2020

In accordance with the methodology of the constructivist approach, the personal identity manifested as a unique self-image is regarded as a dynamic hierarchical system. Under that approach, based on M. Kuhn and T. McPartland’s test, we have developed and put into practice a special questionnaire, which allows ranking16 categories in terms of their importance. These categories reflect social role components of self-image in the main spheres of life, thus presenting an individual or a group identity structure as an orderly hierarchy. Based on a sample of 1251 students of various sex, age, nationality, confession, residence and field of study, we haveproved that affiliation to a certain social or cultural group influences the hierarchy of self-image components. The study has shown that of the highest impact on the significance of self-image components is gender and professional affiliation, and, albeit less substantial, belonging to a particular ethnoreligious group and being theresident of a certain region. Sociocultural affiliation in all instances was an important differentiating characteristic, which determined the disparities in significance of the respective basis of the identity in the hierarchy. At the same time, sociocultural affiliation in most cases had an effect on the importance of less than a half of the other self-image components, thus determining the general structure of the identity. In conclusion, gender, educational and professional, ethnic, confessional or regional sociocultural group is a significant social determinant of personal development in the formation of the self-image hierarchy, which underlies the characteristics and structure of one’s identity.

Keywords: identity, self-image, sociocultural environment, youth, students.
Autoantibodies to 21-hydroxylase as a diagnostic marker of primary autoimmune adrenal insufficiency, including at its potential and latent stages
Authors: Nuralieva N. F. , Yukina M. Yu. , Troshina E. A. , Malysheva N. M. , Nikankina L. V. 
Published: May 2020

Rationale: In Russia, assessment of anti-P450c21 antibodies (AB) in the diagnosis of autoimmune adrenal insufficiency (AAI) has not been commonly used, and the disease screening has not been implemented.Aims: 1) To determine the sensitivity and specificity of anti-P450c21 AB determination in the AAI diagnosis; 2) To estimate the prevalence of anti-P450c21 AB carriage in patients without AAI.Materials and methods: Anti-P450c21 AB were assessed in 40 patients (group 1) with manifest AAI; 171 patients without established diagnosis of AAI, including 113 subjects with autoimmune thyroid disorders or type 1 diabetes mellitus (AID, group 2); 25 carriers of AB markers of thyroid AID and/or type 1 diabetes mellitus without any target organ dysfunctions (group 3); 33 patients with non-autoimmune endocrine disorders (group 4), and 25 healthy individuals (group 5).Results: Determination of anti-P450c21 AB for the diagnosis of AAI had 95% sensitivity, with specificity of 100%, predictive value of a positive result of 100%, and predictive value of a negative result 92.6%. Anti-P450c21 AB were inversely correlated with the duration of glucocorticoid replacement therapy (r=-0.222, p<0.05). High levels of anti-P450c21 AB were found in 4 (3.5%) patients of group 2; based on the results of additional hormonal testing, 50% cases were diagnosed with the latent stage of the disease and 50% cases with the potential stage.Discussion: The sensitivity of the anti-P450c21 AB determination for AAI diagnosis in our study was higher, than in the works by other authors. We have confirmed a time-related reduction of anti-P450c21 AB levels, whereby the strength of the correlation was higher in the subgroups with autoimmune polyendocrine syndrome type II and, to a greater extent, autoimmune polyendocrine syndrome type I. This might be related to their different pathogenesis, with an abnormality of central immune tolerance in autoimmune polyendocrine syndrome type I and that of peripheral immune tolerance in autoimmune polyendocrine syndrome type II. According to our data, in 50% of cases, the development of AAI was preceded by the manifestation of other AIDs (in 15% of cases being multiple). Among all patients with no AAI diagnosis at the study entry, increased anti-P450c21 AB levels were found exactly in those with pre-existing AID. Thus, we have confirmed the feasibility of AAI screening primarily in a cohort of patients with other AID (especially multiple) belonging to the risk group.Conclusion: The determination of blood anti-P450c21 AB is a highly sensitive and highly specific method to diagnose AAI. The frequency of anti-P450c21 AB detection might depend on the duration of glucocorticoid treatment. Screening for early AAI stages is relevant primarily in the risk groups with multiple autoimmune disorders.
HUBUNGAN ANTARA CLASSROOM ENVIRONMENT, TEACHER-STUDENT INTERPERSONAL BEHAVIOR, SERTA PRESTASI BELAJAR MAHASISWA PROGRAM STUDI MATEMATIKA [THE RELATIONSHIP BETWEEN THE CLASSROOM ENVIRONMENT AND TEACHER-STUDENT INTERPERSONAL BEHAVIOR ON THE LEARNING ACHIEVEMENT OF MATHEMATICS DEPARTMENT STUDENTS]
Authors: Ferdinand Ferry Vincenttius , Lukas Samuel 
Published: May 2020

<p>Improving learning achievement is an activity that needs to be continuously carried out by an educational institution, and it is necessary to focus on certain areas because of the many things that affect learning achievement. This study focused on the area of the classroom environment and teacher-student interpersonal behavior to see the relationship between each variable with learning achievement, and the relationship between the two variables. By using a sample of 160 X-university students majoring in mathematics and then using the Chi-Square test method with a contingency table to determine the relationship between each variable and learning achievement. Then using the Pearson correlation method the relationship between classroom environment with the teacher-student interpersonal behavior was tested. Based on the analysis and calculation of the research conducted, it can be concluded that the classroom environment has a good relationship with learning achievement in the mathematics major and general subjects. Whereas the teacher-student interpersonal behavior shows a positive relationship with learning achievement in the dimensions of leadership, understanding, and friendly/helping but a negative relationship in the dimensions of strictness and disatisfaction. In the mathematics major, the dimensions of uncertainty and admonishing are negatively related to learning achievement, but not for general subjects.</p><p><strong>BAHASA INDONESIA ABSTRACT: </strong>Meningkatkan prestasi belajar merupakan kegiatan yang masih terus dilakukan dan berkembang, sehingga diperlukan fokus pada area tertentu. Penelitian ini terfokus pada area <em>classroom environment </em>dan <em>teacher-student interpersonal behavior</em> untuk melihat hubungan antara masing-masing variabel dengan prestasi belajar, dan hubungan antara kedua variabel. Penulis mengambil 160 sampel mahasiswa program studi matematika universitas X, kemudian menggunakan metode uji Chi-Square dengan tabel kontingensi akan dilihat hubungan antara masing-masing variabel dengan prestasi belajar. Lalu akan diuji menggunakan metode korelasi <em>r</em> pearson untuk melihat hubungan antara kedua variabel. Dari hasil analisa dan perhitungan penelitian yang dilakukan, dapat diambil kesimpulan <em>Classroom Environment</em> memiliki hubungan dengan prestasi belajar dalam mata kuliah matematika maupun umum. Sedangkan <em>teacher-student interpersonal behavior </em>memperlihatkan hubungan positif dengan prestasi belajar dalam dimensi <em>leadership, understanding, </em>dan <em>friendly/helping</em> serta hubungan negatif dalam dimensi <em>dissatisfied </em>dan <em>strict</em>. Pada mata kuliah matematika, dimensi <em>uncertain </em>dan <em>admonishing</em> berhubungan negatif dengan prestasi belajar, tapi tidak untuk mata kuliah umum.</p>
A Prestação de Serviços Públicos pelo Governo Eletrônico
Authors: Dias Gilmara Aparecida De Freitas , Coura Karla Veloso , Athayde André Luiz Mendes , Farias Josivania Silva , Demo Gisela 
Published: May 2020

A forma como o governo proporciona a entrega de serviços aos cidadãos tem sido influenciada pela modernização das Tecnologias de Informação e Comunicação (TIC’s) e pelo uso da internet, o que vem gerando acesso facilitado por meio do governo eletrônico (e-gov). Desse modo, este trabalho tem como objetivo analisar o perfil da produção científica internacional sobre a entrega de serviços públicos pelo governo eletrônico. Para tanto, buscou-se identificar nos artigos os elementos demográficos, explorando os objetivos, resumos e palavras-chave e verificando estatísticas textuais, especificidades de grupos, classificação hierárquica descendente e nuvens de palavras no corpus textual, composto por 21 artigos extraídos da base de dados do Science Direct Proquest. Como métodos de análise, foram utilizadas a bibliometria, a sociometria, por meio da aplicação do software Iramuteq, a classificação hierárquica descendente (CHD) e a análise fatorial de correspondência (AFC). Em linhas gerais, os resultados retrataram que a temática mais publicada refere-se à adoção de tecnologia seguida pela implementação do e-gov. A análise realizada desvelou os itinerários da produção científica internacional no tema e subsidiou a proposição de uma agenda de pesquisa para estudos ulteriores.
A interação com atores da hélice tríplice e as perspectivas de desenvolvimento de capacidades empreendedoras
Authors: De Oliveira Greicianne Sousa , Renault Thiago Borges 
Published: May 2020

A partir de um estudo de caso de caráter descritivo, o artigo apresenta a experiência de resistência de cooperação academia-mercado do Campus Pinheiral do Instituto Federal do Rio de Janeiro. Ainda que sem um amparo institucional caracterizado pela ausência de um contrato, a cooperação academia-mercado persiste há nove anos na instituição. Por outro lado, esse cenário fragiliza a parceria, expõe os envolvidos a riscos jurídicos e inibe novos projetos. Assim sendo, a pesquisa tem o foco em analisar a experiência da instituição no sentido de desenvolver capacidades empreendedoras. O objetivo é realizar reflexões para subsidiar a criação de uma política de gestão da inovação para o IFRJ. A pesquisa expõe a importância do Marco Legal da Inovação para a promoção de segurança jurídica a trabalhos de cooperação academia-mercado. Discute a respeito do papel dos Institutos Federais com a pesquisa aplicada, o desenvolvimento socioeconômico e a interação com o mercado. Além disso, apresenta que o contexto no IFRJ é favorável para o desenvolvimento de capacidades empreendedoras ao considerar o interesse da alta administração. Mas há dificuldades ao ponderar a existência de uma cultura dominante contra a entrada de capital privado na instituição e o desconhecimento da comunidade sobre incentivos legais.
Sand Provenance from Source to Sink in the Santa Monica Basin, California Borderlands: Significance of Calleguas Creek Input
Authors: Van Grinsven Matthew , Marsaglia Kathleen M. , Romans Brian W. 
Published: May 2020

Abstract
Thorough and accurate models of modern sand sources to the Santa Monica Basin, offshore southern California, are needed to facilitate the interpretation of sediment supply to the Hueneme–Mugu Fan, the largest submarine fan within the basin. Bathymetry and near-seafloor seismic-reflection isopach mapping of basin fill indicate that dominant sources of sand are canyons/channels that enter the basin from the northwest, which are likely fed via longshore drift by the Santa Clara River and Calleguas Creek. Sand within Calleguas Creek varies in composition across its drainage basin, ranging from more quartzofeldspathic in the northeast to more volcaniclastic in the southwest, ultimately producing sand with a compositional fingerprint distinct from that of the Santa Clara River and Santa Monica Mountains. The abundance of volcanic material and lack of metamorphic grains in downstream Calleguas Creek sand stand in stark contrast to the Santa Clara River’s relatively abundant metamorphic lithic fragments. In addition, Calleguas Creek sand can be further differentiated from sand derived from both the Santa Clara River and Santa Monica Mountains because both of these other sources have much higher proportions of plagioclase. The composition of late Pleistocene (&lt;60 ka) sandy turbidites at Ocean Drilling Program Site 1015 on the distal Hueneme–Mugu submarine fan validates Calleguas Creek’s contribution of sandy sediment to this site in the Santa Monica Basin: out of 14 samples, four samples show compositions similar to the Santa Clara River sand, whereas five are similar to Calleguas Creek sand, and six exhibit mixed compositions. There is no indication of input to this distal environment from the southern Santa Monica Mountains. Trends in sand composition within the Santa Monica Basin can be related to alternating and/or mixing of sediment sources, possibly related to sea-level change, as well as frequency of floods/storms, earthquakes, and other destabilizing processes affecting offshore shelf-to-slope regions.