bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular docking, ADMET study and in vivo pharmacological research of N-(3,4-dimetoxyphenyl)-2-{[2-methyl-6-(pyridine-2-yl)-pyrimidin-4-yl]thio}acetamide as a promising anticonvulsant
Authors: Severina Hanna I. , Skupa Olga O. , Voloshchuk Natalya I. , Saidov Narzullo , Bunyatyan Vera A. , Kovalenko Sergiy M. , Georgiyants Victoriya A. 
Published: June 2020

Introduction: The search for new anticonvulsants for epilepsy treatment with higher efficacy and better tolerability remains important. The aim of the present research was an in silico and in vivo pharmacological study of N-(3,4-di­methoxyphenyl)-2-((2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)thio)acetamide (Epirimil) as a promising anticonvulsant.
Materials and methods: A 1H and 13C NMR spectroscopy, LS/MS, and an elemental analysis were used to deter­mine Epirimil structure. An ADMET analysis, as well as a docking study using anticonvulsant biotargets, e.g.: GAB­AAR, GABAAT, CA II, NMDAR, and AMPAR, was carried out. Anticonvulsant activity was proved, using PTZ- and MES-induced seizures in rats and mice, and neurotoxicity was determined using a rotarod test. Influence of Epirimil on the psycho-emotional state of the laboratory animals was determined by an open field test.
Results and discussion: A synthesis method of a promising anticonvulsant Epirimil was modified. The calculated ADMET parameters and a molecular docking into the active sites of anticonvulsant biotargets allowed evaluating the research prospects and predicting possible mechanisms for implementing anticonvulsant activity. A prominent anticonvulsant activity of Epirimil was established using in vivo studies on the model of PTZ-induced seizures in rats and MES-induced seizures in mice. In terms of toxicity, Epirimil belongs to class IV – low toxic substances. The open field test showed that Epirimil had almost no effect on the animals’ behavioral responses: it neither changed their psy­cho-emotional activity, nor increased their anxiety level. ED50, TD50 and protective index of Epirimil according to its anticonvulsant activity were calculated.
Conclusion: The obtained experimental results substantiate the prospects of N-(3,4-Dimethoxyphenyl)-2-((2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)thio)acetamide as a promising active pharmaceutical ingredient having a multifactor mechanism of anticonvulsant activity.
Graphical abstract:
Modeling of Influence of Climate Change Character on the Territory of the Cryolithozone on the Value of Risks for the Road Network
Authors: Trofimenko Yury Vasilievich , Yakubovich Anatoly Nikolaevich , Yakubovich Irina Anatolievna , Shashina Elena Vldimirovna 
Published: June 2020

The level of climate risks is proposed to be estimated by the amount of thawing soil settlement in the formation of automobile roads, corresponding to the accepted scenario of the climate change. An updated algorithm is presented, according to which the average risk assessment for a 4-year period is divided into a risk assessment for individual years. Calculations performed for the climatic conditions of Yakutsk and Urengoy establish a significant dependence of the predicted risk on the warming pattern. The level of risk predicted when the average annual air temperature increases by 2 degrees is estimated as average (up to 526 points on a 1000-point scale). The most appropriate method of reducing this risk is to perform timely repairs to bring the road to the standard technical and operational condition without the use of special technologies for regulating the temperature regime of soil.
Marcel Jousse (1886-1961) : Anthropologie du geste et « style oral », la parole et le geste au cœur du processus de cognition
Authors: Langlois Roberte 
Published: June 2020

M. Jousse est un anthropologue français de la première moitié du xxe siècle, encore mal connu en France. À l’origine des théories de « l’Anthropologie du Geste » et de l’oralité dont « le Style1 oral », M. Jousse a cherché à faire émerger les principes universels de transmission et de cognition dont il a éprouvé la validité lors de ses rencontres avec des populations de culture orale. Il vérifie notamment les liens étroits entre oralité et mémoire, entre geste et mémorisation. Aujourd’hui les travaux de M. Jousse trouvent écho chez les chercheurs des sciences cognitives et les découvertes contemporaines de l’imagerie cérébrale, qui attestent du rôle dynamique de la parole et du geste comme facilitateurs de la mémoire. Le concept de « style oral » associe dans la parole humaine le corps et les gestes qui contribuent à la mémorisation. Anthropologue mais aussi pédagogue, M. Jousse a formé des éducateurs pour les encourager à favoriser les pratiques de l’oral dans les classes. Pour finir, l’article apporte le témoignage d’une recherche-action inspirée par la pensée éducative de M. Jousse.
Comment se manifeste le continuum oralité/littératie ?
Authors: Margolinas Claire , Laparra Marceline 
Published: June 2020

Cet article a deux visées : une visée théorique de caractérisation du continuum oralité/littératie ; et une visée d’analyse d’un corpus que nous avons constitué auprès d’élèves de CM1-CM2 engagés dans une tâche de classification sur la langue. Dans cet article, nous entendons montrer que les connaissances des deux univers de l’oralité et de la littératie continuent de coexister chez ces élèves, ce qui pourrait avoir des conséquences didactiques importantes. Les connaissances littératiennes sont indispensables pour organiser la pensée. Les tableaux sont souvent uniquement vus comme un type de représentation sémiotique et ne sont rencontrés par les élèves qu’en réception et pratiquement jamais en production. Notre travail montre que cette simple rencontre, même fréquente, ne suffit pas à construire des connaissances permettant d’être utiles en situation.
Le livre numérique enrichi : quels enjeux de littératie en contexte pédagogique ?
Authors: Tréhondart Nolwenn 
Published: June 2020

Convoquant une pluralité de ressources sémiotiques (texte, son, vidéo, images animées…), le livre numérique enrichi est devenu un support d’apprentissage régulièrement mobilisé dans les pratiques pédagogiques (manuels numériques, création d’ebooks sur tablettes tactiles). En prenant appui sur des entretiens que nous avons menés entre 2011 et 2016 auprès d’une trentaine de concepteurs de livres numériques, nous examinons dans cet article la manière dont ce dispositif symbolique et technique, à travers ses formes graphiques et les représentations souvent paradoxales qu’il suscite, pourrait constituer une porte d’entrée pertinente dans l’apprentissage d’une « littératie médiatique multimodale » en contexte numérique.
Vortex dynamics under pulsatile flow in axisymmetric constricted tubes
Authors: Barrere Nicasio , Brum Javier , L'her Alexandre , Sarasúa Gustavo L. , Cabeza Cecilia 
Published: June 2020

Improved understanding of how vortices develop and propagate under pulsatile flow can shed important light on the mixing and transport processes occurring in such systems, including the transition to turbulent regime. For example, the characterization of pulsatile flows in obstructed artery models serves to encourage research into flow-induced phenomena associated with changes in morphology, blood viscosity, wall elasticity and flow rate. In this work, an axisymmetric rigid model was used to study the behaviour of the flow pattern with varying degrees of constriction ($d_0$) and mean Reynolds ($\bar{Re}$) and Womersley numbers ($\alpha$). Velocity fields were obtained experimentally using Digital Particle Image Velocimetry, and generated numerically. For the acquisition of data, $\bar{Re}$ was varied from 385 to 2044, $d_0$ was 1.0 cm and 1.6 cm, and $\alpha$ was varied from 17 to 33 in the experiments and from 24 to 50 in the numerical simulations. Results for the Reynolds numbers considered showed that the flow pattern consisted of two main structures: a central jet around the tube axis and a recirculation zone adjacent to the inner wall of the tube, where vortices shed. Using the vorticity fields, the trajectory of vortices was tracked and their displacement over their lifetime calculated. The analysis led to a scaling law equation for maximum vortex displacement as a function of a dimensionless variable dependent on the system parameters Re and $\alpha$.
MIGRATION PROCESSES IN RUSSIA AND THE ORENBURG
REGION IN THE POST-SOVIET PERIOD
Authors: Алексенко М.А. 
Published: June 2020

Статья посвящена анализу состояния миграционных процессов в
Оренбургской области в постсоветский период. С 1991 по 2019 гг. численность
мигрантов, направленность миграционных потоков и их причины на уровне Рос-
сии, Приволжского федерального округа и Оренбургской области подверглись
существенным изменениям. Сменились мотивы миграции – с политических на
экономические, изменился вектор миграции в первые годы постсоветского пе-
риода с Прибалтики на Центральную Азию. В исследовании представлены ко-
личественные показатели миграций на уровне страны и региона, рассмотрены
причины миграций и изменения, происходившие в них.
The article is devoted to the analysis of the state of migration processes in the Orenburg region in the post-Soviet
period. From 1991-2019 the number of migrants, the direction of migration fl ows and their causes at the level of Russia, the
Volga Federal District and the Orenburg Region underwent signifi cant changes. The motives of migration have changed -
from political to economic ones, the vector of migration in the early years of the post-Soviet period has changed from the
Baltics to Central Asia. The study presents quantitative indicators of migration at the country and region level and considers
the causes of migration and the changes that have occurred in them.
STEK PUCUK MASOI (Cryptocarya massoia) DENGAN PEMBERIAN BERBAGAI KONSENTRASI IBA (INDOLE BUTYRIC ACID)
Authors: Wilson Miriono  , Rettob Bernadus Benni , Tampang Ana 
Published: June 2020

Masoi (Cryptocarya massoia) memiliki nilai ekonomi tinggi namun belum dibudidayakan secara luas. IBA (Indole Butyric Acid) sering digunakan untuk meningkatkan keberhasilan stek tanaman. Tujuan dari penelitian adalah untuk mengevaluasi beberapa konsentrasi IBA (Indole Butyric Acid) terhadap pertumbuhan stek masoi. Penelitian menggunakan empat perlakuan konsentrasi larutan IBA yaitu kontrol (tanpa IBA), IBA 75 ppm, 100 ppm, dan 125 ppm. Persentase stek hidup tertinggi (65%) diperlihatkan oleh kontrol dan perlakuan konsentrasi larutan IBA 125 ppm. Sementara persentase stek bertunas dan stek berkalus menunjukan bahwa semua perlakuan yang diberikan tidak berbeda secara signifikan.
POTENSI KARBON BERBASIS PEKARANGAN DI KAMPUNG MUBRAIDIBA KABUPATEN MANOKWARI
Authors: Udimeraa Katrin Sriyani , Zulfikar Mardiyadi  , Dina Arung Padang  
Published: June 2020

Identifikasi potensi biomasa dan karbon penting dalam upaya kontribusi menjaga keseimbangan lingkungan global. Tujuan dari penelitian ini adalah untuk mengetahui besaran potensi karbon pekarangan di kampung Mubraidiba. Metode yang digunakan ialah deskriptif dengan teknik observasi lapang yang dilakukan secara sensus terhadap seluruh tanaman pertanian, perkebunan dan kehutanan yang selanjutnya dibagi berdasarkan keleas diameter. Persamaan alometrik digunakan untuk menduga besaran nilai biomasa yang disesuaikan dengan karakteristik dan jenis tanaman yang ditemukan. Hasil penelitian menunjukkan bahwa jenis-jenis tanaman di pekarangan kampung Mubraidiba dilakukan pada 2 (dua) kelas diameter, yaitu kelas diameter 5-30 cm dan kelas diameter 30 cm up. Selain itu, pengelompokan tanaman juga dilakukan berdasarkan jenis tanaman kehutanan, pertanian dan perkebunan dengan jumlah jenis tanaman pertanian dan perkebunan pada kelas diameter 5 - 30 cm lebih banyak (66,67%) dibanding jenis tanaman kehutanan (33,33%). Selain itu, fungsi antara kebun campuran dan pekarangan sedikit berbeda antara kebun campuran dengan tujuan produktivitas dan pekarangan dengan fungsi produktivitas dan fungsi keindahan serta kenyamanan tinggal. Rata-rata nilai biomasa pohon untuk kelas diameter 5-30 cm adalah 1,9951 ton/pekarangan, sedangkan rata-rata biomasa tanaman pertanian sebesar 1,7035 ton/pekarangan. Rata-rata total nilai karbon pohon diameter 5-30 cm sebesar 2,6994 ton/pekarangan, sementara stok karbon pada tanaman kehutanan rata-rata dengan diameter 5 – 30 cm sebesar 3,7898 ton, sedangkan stok karbon tanaman pertanian dan perkebunan rata-rata sebesar 0,8518 ton/pekarangan.
KULTUR EMBRIO MERBAU (Intsia bijuga OK.) PADA MEDIA MURASHIGE & SKOOG (MS) DIPERKAYA DENGAN ZAT PENGATUR TUMBUH BAP, GA3 dan IBA
Authors: Samuel Bram Sainawal  , Julius D. Nugroho  , Francina F. Kesaulija  
Published: June 2020

Tujuan penelitian ini untuk mencari konsentrasi dan kombinasi zat pengatur tumbuh (IBA, BAP dan GA3) yang cocok guna pertumbuhan embrio dari tanaman Merbau (Intsia bijuga OK.) pada media Murashige & Skoog (MS) untuk mendapatkan tanaman yang sempurna melalui teknik kultur jaringan. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dengan teknik observasi menggunakan perhitungan statistik deskriptif. Hasil penelitian ini menunjukkan bahwa penggunaan eksplan embrio merbau (Intsia bijuga OK.) yang terbaik adalah menggunakan media dengan zat pengatur tumbuh pada media MS + GA3 2 ppm dengan persen hidup 100% dan memiliki persen eksplan kontaminasi 0%. Pertumbuhan tunas pada perlakuan ini terjadi pada umur 86 hari dengan rata-rata pertumbuhan tunas sebesar ± 0,2 cm, persen eksplan bertunas 0%, pada pertumbuhan terbentuknya akar pada minggu ketujuh dari pengamatan.
THE INFLUENCE OF LIQUID CALCIUM SOURCE ON EGGSHELL QUALITY
Authors: Nešić Ksenija , Pavlović Nikola , Radosavljević Vladimir , Gavrilović Miloš 
Published: June 2020

It is estimated that the world’s population will enlarge by 25% by the middle of this century, resulting in the food production increase by at least 60%. Intensifying egg production is one of the most affordable solutions to provide animal protein. Among many other efforts to improve the quality of eggs, special attention is paid to attempts to provide a better endurance and strength of eggshell, due to the fact that the production of eggs with broken, cracked or soft shells incurs significant economic losses. One of the most important factors to achieve this goal is careful adjustment of calcium in the diet of laying hens, but the nutritional role of calcium is closely linked to that of phosphorus and the effect of vitamin D.
The aim of the experiment was to determine whether two different nutritional supplements of calcium, applied in drinking water of laying hens for two weeks have any significant influence on the shell egg quality. Statistically very significant difference in egg production was observed in the treatment with the product containing calcium and phosphorus. On the other hand, the product consisting of calcium and vitamin D3 had no beneficial impact on the egg parameters.
Based on the obtained results and literature data, it can be concluded that the amount and source of calcium in the diet of laying hens is a very complex and not fully solved issue. Therefore, especially keeping in mind the duration of the experiment, additional research is needed on this subject.
Strength Improvement of Weak Subgrade Soil Using Cement and Lime
Authors: Salahudeen Anigilaje B , Sadeeq Ja’afar A 
Published: June 2020

The study investigate the suitability of subgrade soil in Baure Local Government Area of Kastina State Nigeria for road construction. The strength properties of the subgrade was improved using lime and cement. Several analysis including the particle size distribution, specific gravity, Atterberg limits, compaction characteristics, unconfined compressive strength and California bearing ratio tests were performed on natural and lime/cement treated soil samples in accordance with BS 1377 (1990) and BS 1924 (1990) respectively. Soil specimens were prepared by mixing the soil with lime and cement in steps of 0, 3, 6, and 9% by weight of dry soil in several percentage combinations. The Atterberg limits of the weak subgrade soils improved having a minimum plasticity index value of 5.70 % at 3%Lime/6%Cement contents. The maximum dry density (MDD) values obtained showed a significant improvement having a peak value of 1.66 kN/m3 at 9%Lime/9%Cement contents. Similarly, a minimum value of 18.50 % was observed for optimum moisture content at 9%Lime/9%Cement contents which is a desirable reduction from a value of 25.00 % for the natural soil. The unconfined compressive test value increased from 167.30 kN/m2 for the natural soil to 446.77 kN/m2 at 9%Lime/9%Cement contents 28 days curing period. Likewise, the soaked California bearing ratio values increased from 2.90 % for the natural soil to 83.90 % at 9%Lime/9%Cement contents. Generally, there were improvements in the engineering properties of the weak subgrade soil when treated with lime and cement. However, the peak UCS value of 446.77 kN/m2 fails to meet the recommended UCS value of 1710 KN/m2 specified by TRRL (1977) as a criterion for adequate stabilization using Ordinary Portland Cement. Keywords: Weak subgrade soil, Lime, Cement, Atterberg limits, Maximum dry density, Optimum moisture content, Unconfined compressive strength, California bearing ratio
Investigating Predictive Capabilities of RBFNN, MLPNN and GRNN Models for LTE Cellular Network Radio Signal Power Datasets
Authors: Isabona Joseph , Osaigbovo Anthony I 
Published: June 2020

Efficient radio frequency signal coverage planning with well configured transmitters and receivers’ communication channels, is the heart of any cost-effective cellular network design, deployment and operation. It ensures that both network quality and coverage are simultaneously make best use of (i.e. maximized). This work aim to appraise the adaptive learning and predictive capacity of three neural network models on spatial radio signal power datasets obtained from commercial LTE cellular networks. The neural network models are radial basis function neural network (RBFNN), multilayer perceptron neural network (MLPNN) trained with Bayesian regulation algorithms and general regression neural network (GRNN) models. Largely, it is established from the results that ANN prediction methods can tolerate and adapt to measurement errors of attenuating LTE radio signals. Performance comparisons reveal that all the neural network models can predict the propagated LTE radio signals with considerable errors. Specifically, RBFNN delivered the overall best performance with the smallest mean absolute percentage error, root mean square error, mean absolute error and standard deviation values. The GRNN model also gave better prediction results with marginal errors compared to the MLPNN. Thus, the predictive abilities of RBFNN and GRNN models can be explored as a useful tool to successfully plan or fine-tune mobile radio signal coverage area. Keywords: Neural networks; Signal power; attenuating radio signals; radial basis function multilayer perceptron, general regression neural network, Adaptive signal prediction
La necesidad de la educación literaria en LIJ en la formación inicial de maestras y maestros
Authors: Aguilar Ródenas Consol 
Published: June 2020

<p>Los informes sobre hábitos de lectura señalan que, a partir de segundo de la ESO, se produce una deserción de la lectura. La razón es que desde el sistema educativo no se ha conseguido una educación literaria que les incite, desde el placer, a continuar leyendo. Una parte de este mismo estudiantado será el que, posteriormente, se convertirá en estudiantado de la titulación de Maestro-a. La necesidad de una DLIJ que atienda a las evidencias que nos aporta la investigación es muy importante para conocer el estado de la cuestión y poder avanzar, es decir, debemos atender a los resultados de las investigaciones que en los últimos catorce años nos indican, en el contexto de la universidad española, que cuando ingresan en la Universidad no son lectores y lectoras expertos. Igualmente importante es implementar una DLIJ que incluya aquellas teorías y prácticas que producen transformación en el estudiantado favoreciendo la educación literaria en su formación como maestras y maestros. La asignatura de LIJ puede convertirse en la palanca de transformación identitaria literaria del estudiantado, (re)construida, como señala Duszynski (2016) desde su propia historia de lectora y lector.</p>
Global technologies, glocal approach: a false paradox
Authors: Schafer Valérie 
Published: June 2020

This article seeks to identify the factors that have led researchers to root their historical approach in a national or regional context, rather than a global one. This may seem paradoxical when the Internet is thought to be global, and digital content and cultures at least partially cross-borders. These approaches are determined by reactions to a history of the Internet that has been far too focused on the United States from the outset, by a desire to consider this history in a given context, and by the historical sources. However, the use of national and regional approaches does not preclude the stimulating comparative or transnational perspectives that may renew this history in terms of infrastructure, missing narratives and user participation, as well as technical and human networks. We even suggest that studying the history of the places, people and communities that remain outside networks (whether by choice or by necessity) could tell us a lot about the global and asymmetric reality of the Internet.
Constitucionalismo Crítico: Antonio Negri à luz de Franz Neumann
Authors: Rodriguez José Rodrigo 
Published: June 2020

Este artigo discute a visão de poder constituinte de Antonio Negri à luz da teoria do direito de Franz Neumann. O texto apresenta as características essenciais do constitucionalismo e a sua crítica por Negri (2015) no livro O Poder Constituinte. Para Negri (2015), o constitucionalismo tem como função central impedir a transformação social radical por meio da con- tenção do poder constituinte. A seguir, o texto discute essa crítica à luz de Franz Neumann (2009; 2013) procurando mostrar que nem toda transformação radical é necessariamente progressista, especialmente se deixar de lado algumas garantias presentes na tradição do constitucionalismo.