bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of sarecycline by UPLC-MS/MS and its application to pharmacokinetic study in rats
Authors: Shen Yonghui , Meng Deru , Chen Feifei , Jiang Hui , Hu Liming , Zhou Yunfang , Zhang Miaomiao 
Published: September 2020

AbstractSarecycline is a narrow-spectrum antibiotic for the treatment of acne, which is a chronic inflammatory disease of the hair follicle sebaceous glands. In the study, UPLC-MS/MS was used to establish a rapid and accurate analytical method. The sarecycline was determined with poziotinib as internal standard (IS) in rat plasma. An ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 μm) could performe chromatographic separation with the mobile phase (methanol: water of 0.1% formic acid) with gradient elution. The ions of target fragment were m/z 488.19→410.14 for sarecycline and m/z 492.06→354.55 for poziotinib, which could quantify the electrospray ionization of positive multiple reaction monitoring (MRM) mode. The linear calibration curve of the concentration range was 1–1,000 ng/mL for sarecycline with a lower limit of quantification (LLOQ) of 1 ng/mL. The mean recovery was between 82.46 and 95.85% for sarecycline and poziotinib in rat plasma. RSD for precision of inter-day and intra-day were between 3.24 and 13.36%, and the accuracy ranged from 105.26 to 109.75%. The developed and validated method was perfectly used in the pharmacokinetic study and bioavailability of sarecycline after intravenous and oral administration in rats.
Kedudukan Jaminan Hak Tanggungan Yang Dibuat Tanpa Persetujuan Mantan Istri Dalam Perbankan : Studi Putusan Mahkamah Agung Nomor 222k/Pdt/2017
Authors: Tektona Rahmadi Indra 
Published: September 2020

Bank dalam memberikan pembiayaan atau kredit kepada masyarakat memiliki keyakinan atas kesanggupan debitur dalam rangka pengembalian hutang sesuai isi perjanjian yang telah disepakati. Salah satunya yakni diberikannya jaminan hak tanggungan sebagai agunan oleh debitur kepada pihak bank selaku kreditur. Kewenangan terkait pemberian Hak Tanggungan tercantum pada pasal 8 ayat (1) Undang – Undang Hak Tanggungan. Apabila objek jaminan terdapat dalam sebuah perkawinan, maka objek jaminan tersebut dikatakan sebagai harta bersama sehingga objek jaminan itu milik pasangan suami istri tersebut. Namun, perkawinan yang putus karena perceraian akan berakibat pada kewenangan terkait harta bersama tersebut. Penelitian ini bertujuan untuk mengetahui aturan mengenai benda jaminan yang berasal dari harta yang diperoleh semasa perkawinan milik sepasang suami istri yang sudah bercerai/berpisah. Metode penelitian yang digunakan yaitu metode penelitian Yuridis Normatif serta pendekatan kualitative sehingga memfokuskan penelitian terkait penerapan kaidah serta norma dalam hukum positif yang menghasilkan Kepastian hukum dalam pemberian benda jaminan yang berasal dari harta Bersama yang didapat semasa perkawinan pasangan suami istri yang sudah berakhir disebabkan perceraian tidak diatur dalam Hukum Perbankan.
Fibroblast Growth Factor Receptor (FGFR) Inhibitors in Urothelial Cancer
Authors: Garje Rohan , An Josiah , Obeidat Mohammad , Kumar Kranthi , Yasin Hesham A. , Zakharia Yousef 
Published: September 2020

AbstractDysregulated fibroblast growth factor receptor (FGFR) signaling is associated with several cancers, including urothelial carcinoma. Preclinical studies with FGFR inhibitors have shown significant antitumor activity, which has led to clinical evaluation of multiple FGFR inhibitors. Recently, erdafitinib was approved by the U.S. Food and Drug Administration for advanced urothelial carcinoma with FGFR gene alterations as the first molecularly targeted therapy. Additional ongoing clinical trials with other types of FGFR inhibitors have shown encouraging results. This review summarizes the oncogenic signaling of FGFR alterations, completed and ongoing clinical trials of FGFR inhibitors, and resistance patterns.Implications for PracticeDysregulated fibroblast growth factor receptor (FGFR) signaling is associated with several cancers, including urothelial carcinoma. Preclinical studies with FGFR inhibitors have shown significant antitumor activity, which has led to clinical evaluation of multiple FGFR inhibitors. Most recently, erdafitinib was approved by the U.S. Food and Drug Administration for advanced urothelial carcinoma with FGFR gene alterations as the first molecularly targeted therapy. Additional ongoing clinical trials with other types of FGFR inhibitors have shown encouraging results. This review summarizes the oncogenic signaling of FGFR alterations, completed and ongoing clinical trials of FGFR inhibitors, and resistance patterns.
Patients’ Understanding of Oncology Clinical Endpoints: Environmental Scan and Focus Groups
Authors: Sullivan Helen W. , O'Donoghue Amie C. , Ferriola-Bruckenstein Kate , Tzeng Janice P. , Boudewyns Vanessa 
Published: September 2020

Abstract

Background
Understanding treatment options is important for patients with cancer and their caregivers. This may be difficult, however, because oncology treatments are often approved based on complex clinical endpoints. The study aimed to explore lay understanding of oncology clinical endpoints by assessing the definitions of clinical endpoints available online and gathering qualitative focus group data on cancer survivors’ and the general public's understanding of clinical endpoints.

Methods
We conducted an environmental scan to find Web sites accessible by a general audience that defined three clinical endpoints: overall survival, progression-free survival, and response rate. Next, we conducted a series of eight focus groups across the U.S. with cancer survivors (n = 36) and general population adults (n = 36).

Results
We found several online resources defining each endpoint; however, many of the definitions we identified used technical language that may not be easily understood by patients and caregivers. Few focus group participants were familiar with the technical terms for these endpoints. When presented with the endpoint terms and definitions, participants had misconceptions about treatment efficacy. Specifically, they tended to expect that all endpoints were a variation on living longer.

Conclusion
The results point to the need for more patient-friendly definitions of clinical endpoints developed with input from the general public and from patients with cancer.

Implications for Practice
As the number of oncology prescription drug approvals and the advertising of those drugs to consumers increase, it is timely and critical to understand how to discuss treatment benefits with patients. Patient-friendly definitions of common clinical endpoints, such as overall survival and progression-free survival, would help health care providers describe treatment benefits to patients. This research provides evidence regarding patients’ understanding of these endpoints and suggests definitions for additional research. This represents a first step in creating evidence-based patient-friendly language to describe clinical endpoints.
Approach to the Patient with COVID-19-Associated Thrombosis: A Case-Based Review
Authors: Chen Evan C. , Zon Rebecca L. , Battinelli Elisabeth M. , Connors Jean M. 
Published: September 2020

Abstract

Coronavirus disease 2019 (COVID-19) is a current global pandemic caused by the novel coronavirus SARS-CoV-2. Alongside its potential to cause severe respiratory illness, studies have reported a distinct COVID-19-associated coagulopathy that is characterized by elevated D-dimer levels, hyperfibrinogenemia, mild thrombocytopenia, and slight prolongation of the prothrombin time. Studies have also reported increased rates of thromboembolism in patients with COVID-19, but variations in study methodologies, patient populations, and anticoagulation strategies make it challenging to distill implications for clinical practice. Here, we present a practical review of current literature and uses a case-based format to discuss the diagnostic approach and management of COVID-19-associated coagulopathy.
Journey to Ancestry: Reclaiming of Identity and Home in Toni Morrison’s Song of Solomon
Authors: Kakoti Jiban Jyoti 
Published: September 2020

Journeys play a vital role in the lives of African Americans insofar as their quest for home in America is concerned. These journeys substantially contribute to their understanding of the impact of slavery and racism on themselves and their ancestors without which they are not in a position to materialize their dream for a viable home and identity. ‘Memory’ and ‘re-memory help them to evoke traumas that their ancestors had undergone and compare the same with their firsthand traumas in the present. These journeys thus enable them to get matured and knowledgeable so that they can adapt themselves to the new condition. The paper is an attempt to explore in a better way Toni Morrison’s representation of pain and pleasure of such journeys in her novel Song of Solomon, which enable her black characters to reconstruct their identities and regain self-esteem so that they find themselves in a position to make home possible.
STUDI PENGOLAHAN MINERAL ZIRCON (ZrO²) MENJADI ZIRCONIA PADA PT KALIMANTAN ZIRCON INDUSTRI DI DESA GOHONG KECAMATAN KAHAYAN HILIR KABUPATEN PULANG PISAU
Authors: Abbas Abbas , Triantoro Agus , Riswan Riswan 
Published: September 2020

Konsentrat zircon di PT Kalimantan Zircon Industri diproses melalui metode pengolahan gravity consentration menggunakan meja goyang, magnetic separation, dan elektrostatic separation. PT Kalimantan Zircon Industri menarget produksi sebanyak 80 ton per hari pada shif siang mulai pukul (07.00 – 16.00 WIB) dan shif malam (16.00 – 01.00 WIB).Penelitian ini dilakukan dengan pengamatan secara langsung di lapangan dan mengkompilasi data tersebut dengan literatur berdasarkan teori yang berkaitan dengan pengolahan bahan galian khususnya mineral zircon menjadi zirconia. Peraturan Menteri Energi dan Sumber Daya Mineral Nomor 7 Tahun 2012 tanggal 6 Februari 2012 mengamanatkan bahwa pelaku usaha yang bergelut di bidang pengolahan mineral zircon diwajibkan melakukan peningkatan nilai tambah mineral melaui pengolahan dan pemurnian dengan kadar mineral zirconia berupa produk akhir 65,6 %. Rangkaian proses pengolahan ini dimulai dari pengolahan pada sluice box, meja goyang, magnetic separation, dan elektrostatic separation dan pengulangan pengolahan pada pada sluice box, meja goyang, magnetic separation, dan elektrostatic separation serta mengkaitkan pengaruh kecepatan air tipis pada permukaan meja goyang dan peningkatan feed dalam pencapaian target produksi 80 ton per hari dan menganalisid hubungan pencapaian target produksi tersebut dengan feed, material balance dan recovery.Dari hasil penelitian, sebanyak 86 ton material pasir zircon diperlukan untuk mendapatkan konsentrat zirconia 81,8 ton per hari, dengan kecepatan feed 2,384 kg/m, recovery 76,3 %, kecepatan aliran tipis air pada permukaan meja goyang 3,164 m/s, dan volume fluida 48,675 m/s. Kata-kata kunci : feed, konsentrat, pengolahan, zircon
Maternal Factors on Stunting in Pekanbaru Local Health Center, Indonesia
Authors: Septiani Winda , Harahap Elly Satriani , Ismainar Hetty , Zaman M Kamali , Alamsyah Agus , Maharani Riri 
Published: September 2020

Stunting is a health problem by multiple factors (Mother factor, socio-economic factor). The growth retardation (stunting ) was measure by height for age scale which primarily indicates chronic undernutrition. In 2018, the prevalence of stunting in Riau province was 35%, which was higher than the national prevalence of 30.8%. This was an quanitative with cross sectional analytic deign. The study was conducted in Puskesmas Harapan Raya Pekanbaru, Riau, Indonesia. The population was all children (4000), sampel was 187 children by systematic random sampling. Research was to analyze independents variable (risk of stunting) to the dependent’s variable (mother’s age, Prity, Mother Parity, Mother’s Height, (Lila) / MUAC (Mid Upper Arm Circumference), Maternal Characteristics (hemoglobin), Tension Mother’s, ANC Visit, Dietary habit, Mother’s child care, Completed immunization, Weight child and Drink for child.) Research results is maternal hemoglobin ​​in pregnancy with a risk category of having a stunting 53.4%, exlusive breastfeeding with a risk category of having a stunting 54.1%, dietary habit with a risk category of having a stunting 51.3%. Independents variable (Maternal Characteristics (hemoglobin), Exclusive Breastfeeding, Dietary Habis), is a significant association to stunting. The findings from this study will be helpful for programmatic intervention to reduce the stunting.
Karakterisasi Morfologi, Anatomi, dan Fisiologi Tujuh Klon Unggul Kopi Robusta
Authors: Sakiroh Sakiroh , Ibrahim Meynarti Sari Dewi 
Published: September 2020

<em>Morphological characterization of superior Robusta coffee plants has been widely studied, but for the anatomical and physiological character is still relatively limited. Result of this characterization is important as a basic information in order to create the new superior varieties. The purpose of this study was to investigate the morphological, anatomical, and physiological characteristics of seven clones of Robusta coffee (SA 203, BP 534, BP 42, BP 409, BP 939, BP 308 and BP 436). The experiment was conducted at Pakuwon Experimental Station and Integrated Laboratory of Indonesian Industrial and Beverage Crops Research Institute, Sukabumi, West Java, from October to November 2019. The Completely Randomized Design with 7 Robusta coffee clones as treatments and three replications was used in this study. The variable observed were morphological (leaf area), anatomical (stomata shape and density) and physiological characters (chlorophyll a, chlorophyll b and total chlorophyll). The results showed that the leaf area of the first and third leaves of seven clones of Robusta coffee were relatively uniform. The stomata shape of Robusta coffee leaf is parasitic type (Rubiaceous) type. The SA 203 and BP 409 clones have the fewest stomata contents. The content of chlorophyll a, b, and total in the first and third leaves varies between clones. Chlorophyll content in the basal, middle, and apical leaf were relatively uniform, except clones SA 203 and BP 939 for the first leaf, and SA 203 and BP 436 for third leaf. The correlation analysis showed a positive relationship between leaf area and chlorophyll content.</em>
A Comparison of Demographic, Epidemiological and Clinical Characteristics of Hospital Influenza-related Viral Pneumonia Patients
Authors: Fu Bin , Wu Zhengjie , Huang Lingtong , Chai Zhaohui , Zheng Peidong , Sun Qinmiao , Gu Silan , Xu Qiaomai , Feng Haiting , Tang Lingling 
Published: September 2020

Abstract
Objective: Through the comparison of the demographic, epidemiological, and clinical characteristics of hospital human influenza (influenza A (H1N1) pdm09, H3N2, and B) -related and hospitalized avian-origin influenza A (H7N9)-related viral pneumonia patients , find the different between them.Methods: A retrospective study was conducted in hospitalized influenza-related viral pneumonia patients.Results: Human influenza A -related patients in the 35–49-year-old group were more than those with B pneumonia patients (p=0.027), and relatively less in the ≥65-year-old group than B pneumonia patients (p=0.079). The proportion of comorbid condition to human influenza A pneumonia was lower than B pneumonia and H7N9 pneumonia patients (78% vs. 77.8%; p=0.013). The proportion of invasive mechanical ventilation (IMV), lymphocytopenia, elevated lactate dehydrogenase to hospitalized human influenza A-related viral pneumonia patients was higher than B pneumonia patients (p<0.05), but lower than H7N9 pneumonia patients (p<0.05). In the multivariate analysis, pulmonary consolidation (odds ratio (OR): 13.67; 95% confidence interval (CI): 1.54–121.12; p=0.019) and positive bacterial culture (sputum) (OR: 7.71; 95% CI: 2.48–24.03; p<0.001) were independently associated with IMV , while shock (OR: 13.16; 95% CI: 2.06–84.07; p=0.006), white blood cell count >10,000/mm3 (OR: 7.22; 95% CI: 1.47–35.58; p=0.015) and positive bacterial culture(blood or sputum) (OR: 6.27; 95% CI: 1.36–28.85; p=0.018) were independently associated with death in the three types hospitalized influenza-related viral pneumonia patientsConclusions: Hospital influenza B-related viral pneumonia mainly affects the elderly and people with underlying diseases, while human influenza A pneumonia mainly affects the young adults; however, the mortality was similar. The hospitalized human influenza A-related viral pneumonia patients was severer than B pneumonia patients,but milder than H7N9 pneumonia patients. Pulmonary consolidation and positive bacterial culture (sputum) were independently associated with IMV, while shock, white blood cell count >10,000/mm3, and positive bacterial culture (blood or sputum) were independently associated with death to three types hospitalized influenza-related viral pneumonia patients.
Cell-specific Characterization of the Placental Methylome
Authors: Yuan Victor , Hui Desmond , Yin Yifan , Peñaherrera Maria , Beristain Alexander , Robinson Wendy 
Published: September 2020

Abstract
Background: DNA methylation (DNAm) profiling has emerged as a powerful tool for characterizing the placental methylome. However, previous studies have focused primarily on whole placental tissue, which is a mixture of epigenetically distinct cell populations. Here, we present the first methylome-wide analysis of first trimester (n=9) and term (n=19) human placental samples of four cell populations: trophoblasts, Hofbauer cells, endothelial cells, and stromal cells, using the Illumina EPIC methylation array, which quantifies DNAm at >850,000 CpGs.Results: The most distinct DNAm profiles were those of placental trophoblasts, which are central to many pregnancy-essential functions, and Hofbauer cells, which are a rare fetal-derived macrophage population. Cell-specific DNAm occurs at functionally-relevant genes, including genes associated with placental development and preeclampsia. Known placental-specific methylation marks, such as those associated with genomic imprinting, repetitive element hypomethylation, and placental partially methylated domains, were found to be more pronounced in trophoblasts and often absent in Hofbauer cells. Lastly, we characterize the cell composition and cell-specific DNAm dynamics across gestation.Conclusions: Our results provide a comprehensive analysis of DNAm in human placental cell types from first trimester and term pregnancies. This data will serve as a useful DNAm reference for future placental studies, and we provide access to this data via download from dbGAP (phs002013.v1.p1), through interactive exploration from the web browser (https://robinsonlab.shinyapps.io/Placental_Methylome_Browser/), and through the R package planet, which allows estimation of cell composition directly from placental DNAm data.
Reflecting on the Challenges encountered by nurses at the great Kermanshah Earthquake: A qualitative study
Authors: Abdi Alireza , -Raygani Aliakbar Vaisi , Najafi Bahareh , saidi Hamid , moradi khalil 
Published: September 2020

Abstract
Background: Iran has experienced an increasing number of earthquake disasters in the past three decades. Nurses are the largest group of healthcare providers that play an important role in responding to disasters. Therefore, this study aimed to explore the nursing challenges to provide care to the injured in the Kermanshah earthquake, Iran. Methods: The present study was conducted as a qualitative conventional content analysis, and data collection was carried out through 16 semi‑structured and in‑depth interviews with the nurses involved in providing care to the injured in the Kermanshah earthquake. The data were analyzed following Graneheim and Lundman’s approach.Results: Data analysis led to the emergence of 453 primary codes, 14 subcategories, and 5 categories. The five categories were as follows: (a) organizational and managerial challenges; (b) human resources; (c) infrastructure; (d) educational system; (e) and ethical.Conclusion: The results of this study showed that nurses faced several challenges in providing care to earthquake victims. Based on these findings, better educational management and planning, infrastructure reform, and establishment of a crisis nursing national team seem necessary.
[18F]VUIIS1009B Features a Superior Imaging Performance to [18F]DPA-714 in TSPO Density Characterization for Neuroinflammatory PET Imaging
Authors: Huang Chen , Ding Fan , Hao Yong , Hu Zhoumi , Wang Cheng , Li Wei , Wang Mengxin , Peng Wenxian , Tang Dewei 
Published: September 2020

Abstract
Purpose: Translocator protein (TSPO), an outer mitochondrial membrane protein, is regarded as a key biomarker for neuroinflammation in a variety of neurodegenerative diseases. In this study, we aim to evaluate two highly specific TSPO radiotracers [18F]VUIIS1009A and [18F]VUIIS1009B in a mild cerebral ischemic rat model, and to compare their in vivo performance to the well-established TSPO probe [18F]DPA-714 for neuroinflammation imaging. With multiple graphic analytical methods tested and macro parameters determined, we propose to find a suitable and best quantification method to profile neuroinflammation and measure TSPO density with the three TSPO radiotracers.Methods: Cerebral ischemia rat model was created and imaged using [18F]VUIIS1009A, [18F]VUIIS1009B and [18F]DPA-714. Displacement studies using non-radioactive analogs were performed to evaluate the binding specificities of [18F]VUIIS1009A and [18F]VUIIS1009B individually. Imaging analysis using arterial plasma input functions (AIFs) was employed to generate Logan plots and parametric images of total distribution volume (VT) for each radiotracer. Reference Logan model using contralateral brain as a reference region was introduced to generate parametric images for binding potential (BPND). Results: When compared to [18F]DPA-714, [18F]VUIIS1009B demonstrated higher binding potential (BPND) and distribution volume ratio (DVR). Parameter images of BPND and VT also indicate [18F]VUIIS1009B has a superior imaging profile with higher BPND and DVR when compared with other two radiotracers in TSPO imaging. Correlation analysis between BPND for [18F]VUIIS1009B and [18F]DPA-714 also indicates [18F]VUIIS1009B is more sensitive than [18F]DPA-714 in TSPO density measurement.Conclusions: This study demonstrates the superiority of [18F]VUIIS1009B to [18F]VUIIS1009A and [18F]DPA-714 in the neuroinflammation imaging. It also demonstrates that [18F]VUIIS1009B PET imaging coupled with parameter mapping (VT and BPND) and graphic analysis using Logan analysis and reference Logan analysis holds great promise for neuroinflammation characterization and TSPO density measurement.