bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral Activation Patterns Of Older Adults While Performing The Functional Gait Test
Authors: Tavares Larissa Bastos , Souza Idaliana Fagundes de , Filho Bartolomeu Fagundes de Lima , Yano Kim Mansur , Gazzola Juliana Maria , Vieira Edgar Ramos , Cavalcanti Fabricia Azevedo da Costa 
Published: March 2020

Abstract
Dual-task activities are common in daily life and have greater motor/cognitive demands. These are conditions that increase the risk of older adult falls. Falls are a public health problem. Brain mapping during dual-task activities can inform which therapeutic activities stimulate specific brain areas, improving functionality, and decreasing dependence and the risk of falls. The objective of the study was to characterize the brain activity of healthy older adults while performing a dual-task activity called the Functional Gait Test (FGT). Method : This observational study included 30 older adults aged 65 to 75 years, and it was approved by the institutional review board. The FGT consists of walking following a sequence of numbers (simple task), and a sequence of alternating letters and numbers (complex task). During the activity, the subjects had their cortical activation pattern measured using the Emotiv EPOC® electroencephalogram. Complete data was obtained for analysis on 13 participants. The data was analyzed using descriptive statistics (mean and standard deviation), and paired T-tests to compare the brain activity during the conditions (simple vs. complex task). Results : Alpha brain waves were activated in the right and left hemispheres during the simple task, while Alpha brain waves’ activation during the complex task was predominant in the right hemisphere. However, the differences were not statistically significant. The Betha waves had predominant activation in the left hemisphere during the simple task, and predominant activation in the right hemisphere during the complex task. The difference was statistically significant in 11 out of the 14 channels evaluated ( P <0.04). Conclusion: The results corroborates the increased complexity of dual-tasks due to the predominant activation of the right hemisphere, which is related to motor learning process and new stimulus processing.
Physical activity and the prevalence of primary headaches among a large population of university students: The MEPHASOUS study
Authors: Mansouri Masoume , Sharifi Farshad , Varmaghani Mehdi , Shokri Azad , Rahdar HosseinAli , Keshtkar Abasali , Sadeghi Omid 
Published: March 2020

Abstract
Background: Primary headaches have a high prevalence among university students. Lifestyle has an important role in the prevention and management of these headaches. Among lifestyle factors, data on the association between physical activity and primary headaches are scarce and conflicting.Aim: To examine the association between physical activity and primary headaches among a large population of university students.Methods: Totally, 83,463 university students from 28 provinces of Iran were included in the current cross-sectional study. Data on physical activity, dietary intakes, and demographic characteristics were collected using pre-tested questionnaires. Primary headaches were determined according to the International Classification of Headache Disorders-3 (ICHD-3) criteria.Results: Mean age of university students was 21.50 ± 4.01, and 54.7% were female. Primary headaches were prevalent among 9% of students. A significant inverse association was seen between physical activity and primary headaches in the whole population (OR: 0.66, 95% CI: 0.62-0.71). Such an inverse association was also observed after taking potential confounders into account; such that students who were physically active had 21% lower odds of primary headaches compared with those who were physically inactive (OR: 0.79, 95% CI: 0.72-0.87). Also, physical activity was associated with reduced odds of primary headaches in male and female students (Males; OR: 0.70, 95% CI: 0.60-0.82, females; OR: 0.84, 95% CI: 0.75-0.94) as well as those students with normal-weight (OR: 0.79, 95% CI: 0.71-0.87), overweight, or obesity (OR: 0.80, 95% CI: 0.66-0.96).Conclusion: Our findings support the protective association between physical activity and primary headaches.
Exercise-Based and Associated Factors Breastfeeding on HIV-Infected Mothers for Children Age 1-﻿24 Months in Central Zone, Tigray, North Ethiopia, 2019.
Authors: Embaye Hamelmal Mekonen , Gebremeskel Teferi Gebru 
Published: March 2020

Abstract
Background: Breastfeeding exposed to HIV is a major factor in the spread of HIV, but breastfeeding alone poses a significant risk to the baby's health because breastfeeding can reduce the impact of many infections and support some chronic diseases. Therefore, this study was aimed to assess exercise-based and associated factors breastfeeding on HIV-infected mothers for children age 1-24 months in the central zone, Tigray, north Ethiopia. Methods: A Facility-based Cross-Sectional study was conducted from March to April 2019. A systematic random sampling method was used to select study participants. Information was collected using a structured, pre-tested questionnaire. The data is coded, cleaned, copied and entered EPI-info 7 and finally export to SPSS version 22.00 for analysis. Association between independent and dependent variables was first analyzed using binary logistic regression analyses. An alternative bivariate logistic regression analyzes of less than 0.2 were entered in multivariable logistic regression analysis. The statistical association between variance dependent and independent variables was measured using an OR, AOR, 95% CI, and a p-value less than 0.05. Result: 239 HIV-positive mothers participated in this study. Approximately 204(85.4) are favorable attitude in the practice of exclusive breastfeeding. The majority of mothers 206 (86.7%) experienced good breastfeeding. Mothers with Information while exclusive breastfeeding (AOR, 2.57, 95%CI: 1.03- 6.4) and age at first birth (AOR: .247, 95%: (.106- .578) had a significant collaboration on exclusive breastfeeding practice among HIV-infected mothers. Several ANC visits have had a significant collaboration on exclusive breastfeeding practice among HIV-infected mothers (AOR; 3.726 95%CI; 1 .055-13.154).Conclusion: The study found that HIV positive mothers attending health care facilities had a favorable attitude but practiced on EBF is still low. Therefore, train health professionals especially health extension workers to raise awareness education, enhance information, regarding EBF and strength counseling in ANC service is better to improve the HIV positive mother level of attitude and practice to EBF.
The cerebrospinal fluid changes and clinical characteristics of aseptic meningitis in Kawasaki disease
Authors: Hu Fan , Shi Xiaoqing , Fan Yang , Liu Hanmin , Zhou Kaiyu 
Published: March 2020

Abstract
Background: Aseptic meningitis is not a common feature in Kawasaki disease (KD). However, it could cause difficulty in making correct and in-time diagnosis Methods: We retrospectively investigated patients of KD and bacterial meningitis (BM). Totally 38 KD patients and 126 BM patients were brought into this study. Clinical symptoms, signs and laboratory examinations were compared between the two groups, which included: duration of fever before lumbar puncture, conjunctiva injection, oral cavity change, rash, cervical lymphadenopathy and extremities change, vomiting, front fontanel bulging, neck stiffness, leukocytes, hemoglobin, platelets, C-reactive protein, cerebrospinal fluid examinations, liver function and urinalysis. Results: In clinical signs, vomit and neck stiffness were more prevalent in BM. KD patients showed higher blood leukocyte (p<0.001) and C-reactive protein (p<0.001) in the early febrile stage. Glucose in cerebrospinal fluid of BM patients was significantly lower than KD patients (p=0.003). In ROC curve, the optimal cutoff value of CSF glucose was 2.945mmol/L with the sensitivity of 84.2% and specificity of 71.4%. Pyuria was more prevalent in KD patients (p<0.001). There was no significant difference in front fontanel bulging, hemoglobin, platelet, alanine transaminase, aspartate transaminase, albumin, cerebrospinal fluid leukocytes, cerebrospinal fluid protein and cerebrospinal fluid lactate dehydrogenase. Conclusions ： Full investigation of clinical manifestation and laboratory tests is necessary to distinguish KD with aseptic meningitis and BM. In CSF study, glucose level is more efficient than other items to distinguish these two diseases. Decreased CSF glucose is possibly an indicator of BM rather than KD.
Role of Serum Fatty Acids in Children with Henoch-Schönlein purpura by GC-MS analysis
Authors: Wen Min , feng shipin , dang xiqiang , ding xuewei , xu zhiquan , huang xiaoyan , lin qiuyu , xiang wei , he xiaojie 
Published: March 2020

Abstract
BACKGROUND: The objectives of this work were to discover the changes of serum Medium- and Long-Chain fatty acids levels and its possible relationship with Henoch-Schönlein Purpura (HSP), also referred to as Immunoglobulin A vasculitis in children. METHODS: A total of 58 children with HSP and 28 healthy children were recruited for this study. Serum fatty acids were analyzed by gas chromatography with mass spectrometry (GC-MS). RESULTS: 31 species of Fatty acids were discovered to have a significant difference between HSP group and healthy control group (CON group). The contents of all detected 37 fatty acids in the HSP group were higher than the healthy group. Parts of fatty acids were found in our study having significant change according to the treatment. Palmitate (C16:0) and 18 carbon atoms (C18) of fatty acids were abundant in all three groups of HSP. Elaidate (C18:1T), cis-11,14,17-Eicosatrienoic acid ester (C20:1) and cis-15-tetracosenoate (C24:1) were found to have a correlation on renal damage of HSP. CONCLUSION: Our study provides clinical evidence to support that fatty acid metabolism is associated with HSP by GC-MS method. Glucocorticoid therapy has a certain relationship with fatty acid metabolism during HSP treatment. Meanwhile, long-chain MUFAs may have an impact on renal damage of HSP. In addition, we speculate that a low BMI may be a kind of manifestation of abnormal fatty acid metabolism in HSP. All in all, further study is needed to explore the specific mechanism of fatty acids and HSP.
Retrospective analysis of dendriform pulmonary ossification: Possible involvement of inflammation and hemorrhage
Authors: Enomoto Takatoshi , Takimoto Takayuki , Kagawa Tomoko , Tachibana Kazunobu , Sugimoto Chikatoshi , Arai Toru , Sakurai Teiko , Kasai Takahiko , Akira Masanori , Hayashi Seiji , Inoue Yoshikazu 
Published: March 2020

Abstract
BackgroundDendriform pulmonary ossification (DPO) is a rare condition characterized by metaplastic bone formation in the lung parenchyma. DPO has been reported to be often associated with usual interstitial pneumonia (UIP) or chronic aspiration of gastric acid; however, DPO is believed to be a multifactorial disease, and its clinical features and pathophysiology remain unclear. This study aimed to reveal the novel clinical features and pathophysiology of DPO.MethodsThe pathology reports of consecutive cases diagnosed by surgical lung biopsy for diffuse lung diseases (DLDs) between April 1, 2000 and March 31, 2018 were reviewed retrospectively. Cases showing ossification in their specimens were subsequently reviewed and confirmed as calcified density lesions on CT scans. Besides the definite DPO cases, two DPO cases that involved surgical resection of the lung tumor were also included in the study. The clinical, radiological, and pathological features were analyzed.ResultsThree (0.96 %) out of 313 cases with DLDs were identified as cases of definite DPO. Taken together with the two DPO cases showing lung tumors, five DPO cases were analyzed. The patients were predominantly male, with a median age of 69 years. Four cases showed no smoking history. One patient had gastroesophageal reflux disease and UIP, and another had demonstrable hiatal hernia. Laboratory data were not remarkable. Pulmonary function at baseline was almost normal, and no significant decline was observed during the follow-up period. All cases showed interstitial fibrosis accompanied by ossifications. Intriguingly, the histological examination revealed intra-alveolar fibrosis and slight inflammatory cell infiltration, including new bone formation, corresponding to the consolidation on the CT scan in one case. In addition, consolidation, suspected to be caused by inflammation or hemorrhage, was also noted in two other DPO cases, namely in all of three idiopathic cases without UIP or risk factors for gastric acid aspiration.ConclusionsAll five DPO cases were indolent, indicating that the prognosis of DPO might be good. The pathological and radiological findings suggested the possible involvement of pulmonary inflammation and hemorrhage in the pathogenesis of DPO.
Diffuse sclerosing variant of papillary thyroid carcinoma: a case report
Authors: Wang Siyao , Wang Rui , Sun Ruize , Luo Xiaoman , Xuan Yue , Sun Xiaohan , Li Aoxue , Cong Yilin , Zhang Jiayan , Li Pengcheng , Luo Yuan , Li Ji , Liu Yang 
Published: March 2020

Abstract
Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSVPC) is a rare variant of papillary thyroid carcinoma with features of strong ability of invasion, metastasis, relapse, and mortality. Its diagnosis is difficult to obtain because of the special differentiation state of the cancer cells. Case Presentation: A 21-year-old woman arrived at the First Affiliated Hospital of China Medical University in October 2019 because of a peach-pit-sized mass that she had noticed 1 month before. Color duplex ultrasonography findings suggested a thyroid nodule. Conclusions: Based on findings of the specialist examination, physical examination, and thyroid ultrasonography, the patient was initially diagnosed with thyroid neoplasm. Under general anesthesia, thyroidectomy was performed, removing the right lobe and isthmus, and biopsy specimens were obtained from lymph node groups III, IV, and VI on the right side. The final histological diagnosis was DSVPC.
Paeonol suppresses invasion, migration, and epithelial-to-mesenchymal transition in colorectal cancer cells through inhibition of COX-2 and PGE2
Authors: Li Ming , Tan Shi-yun , Yu Yuan-jie 
Published: March 2020

Abstract
Purpose: To observe the effects of paeonol on the invasion and migration of LoVo colorectal cancer cells, and investigate its possible mechanisms. Materials and Methods: Cell transwell assay and wound-healing assay were applied, and the results suggested that paeonol could significantly inhibit the invasion and migration abilities of LoVo cells, which was associated with a reduction in COX-2 expression and PGE2 synthesis. Treatment with the selective COX-2 inhibitor, celecoxib, or transient transfection of colorectal cancer cells with COX-2 siRNA, also inhibited cell invasion and migration. Results: The invasion and migration capacity were evaluated in LoVo cells by transwell assay and wound-healing in vitro. Compared with the control group, the invasion cells through Matrigel and the wound-healing rate were significantly decreased after treated with paeonol for 24 h. Paeonol treatment downregulated the expression of MMP-9 and downregulated the COX-2 expression and PGE2 synthesis in LoVo cells. Paeonol could up-regulate the expression of epithelial marker E-cadherin while down-regulate the expressions of mesenchymal markers, Fibronectin and Vimentin. Paeonol inhibited PI3K-Akt and MAPK-ERK pathways in LoVo cells. Celecoxib treatment significantly decreased the cells penetrating the matrigel in a dose-dependent manner. siRNA knockdown of COX-2 leaded to inhibition of cell invasion in LoVo cells. Knockdown of COX-2 increased the expression of E-cadherin, whereas the expressions of Fibronectin and Vimentin were downregulated. Conclusion: Paeonol may inhibit PI3K-Akt and MAPK-ERK pathways through suppressing of the COX-2 expression and PGE2 synthesis, thus inhibiting the cell invasion, migration, and EMT in LoVo cells.
Is There Need a Specific Scoring System for Acute Appendicitis During Pregnancy?
Authors: Mantoglu Baris , Gonullu Emre , Akdeniz Yesim , Yigit Merve , Firat Necattin , Akin Emrah , Altintoprak Fatih , Erkorkmaz Unal 
Published: March 2020

Abstract
BackgroundAcute appendicitis is the most common non-gynecological emergency during pregnancy. The diagnosis of appendicitis during pregnancy is challenging due to both physiological and laboratory changes. As such, the surgeon needs additional guidance, other than imaging methods, before deciding a surgical intervention. Various scoring methods have been defined and evaluated for the diagnosis of acute appendicitis for a long time. There is no definition of a score for the gestation period, and the comparison of the currently applied scoring methods during the gestation period is not available in the literature.The purpose of our study is to evaluate the efficacy of the most popular scoring systems applied in the diagnosis of acute appendicitis in pregnancy and the tips for introduction to a scoring method for the pregnancy period.MethodsThis single-center retrospective study consists of 79 pregnant patients who were admitted to the emergency department with abdominal pain between May 2014, May 2019 and were diagnosed with acute appendicitis and underwent an appendectomy together with 79 non-pregnant control group who underwent appendectomy for the last 1.5 years. Both laboratory and examination findings required for the scoring methods of the patients were obtained and calculated separately for each patient. Negative appendectomy rates were evaluated according to pathology results. Categorical variables were compared by the Chi-Square test. Categorical variables were presented as a count and percentage. A p-value <0.05 was considered significant. Receiver operator characteristic (ROC) curve analysis was used to identify the best cut-off value and assess the performance of the test score for appendicitis.ResultsThe Tzanakis Score is the strongest among the scoring systems used in non-pregnant women. The positive predictive value (PPV = 90.60) of the Tzanakis Score is 90.6% while the negative predictive value (NPV = 46.7) is 46.7%. RIPASA seems to be the strongest among the scoring systems used in pregnant women. While PPV of this scoring method is 94.40%, NPV is 44%, its sensitivity and specificity are 78.46% and 78.57%, respectively.ConclusionsAlthough the RIPASA score is considerable effective in pregnancy in the diagnosis of acute appendicitis among all scoring systems, a specific scoring system is necessitated for the gestation period.
Doctor-patient Communication skills training for Postgraduate majoring in Oncology Radiotherapy
Authors: Liu Guohui , Liu Feng , Wang Chunbo , Lan Tian , E Mingyan 
Published: March 2020

Abstract
Objective: To evaluate the communicative ability of doctor-patient education for postgraduates majoring in oncology radiotherapy, and to discuss the training mode and effect. Methods: From January 1, 2018 to June 1, 2019, clinical interns of oncology radiotherapy in our hospital (all graduate students) were selected as the research subjects and randomly divided into two groups. A total of 60 cancer radiotherapy interns were randomly divided into experimental group (30 persons) and control group (30 persons); CBL teaching model (introducing training of doctor-patient communication skills) is adopted in experimental group, and traditional CBL teaching model is used in control group. After the end of the teaching, the two groups’ teaching effects are evaluated through the combination of examinations and questionnaires. SPSS 19.0 was applied to do statistical analysis, t test and Wilcoxon were used. Results: SEGUE baseline score of experimental group for doctorpatient communication skills is better than that of SEGUE in the control group, and the difference was statistically significant (P < 0.05). Conclusion: The CBL teaching model which introduces training of doctor-patient communication skills in the practical process in cancer radiotherapy division is conducive to develop practitioners’ good doctor-patient communication and interaction skills.
Peri-treatment peripheral blood cell score predicts long-term locoregional progression hazard in oesophageal squamous cell carcinoma after definitive chemoradiotherapy
Authors: Xu Liangyu , Chen Jianzhou , Guo Hong , Huang Ruihong , Guo Longjia , Yu Yuanxiang , Zhai Tiantian , Wu Fangcai , Chen Zhijian , Li Derui , Chen Chuangzhen 
Published: March 2020

Abstract
Background: Prediction of response to chemoradiotherapy is critical for the optimal management of oesophageal cancer, yet it is still an unmet clinical need. This study aims to evaluate the predictive potential of peri-treatment peripheral blood cells (PBC) in disease progression hazard in oesophageal cancer following chemoradiotherapy.Methods: 87 patients with primary oesophageal squamous cell carcinoma were subjected to definitive concurrent chemoradiotherapy in a phase II trial. PBC parameters (haemoglobin, neutrophils, platelets, lymphocytes and monocytes) were collected at 7 time points through the course of radiotherapy. The values of peri-treatment PBC parameters in predicting 3-year cumulative hazard of tumour progression were evaluated.Results: Patients with disease progression displayed distinct distribution patterns of peri-treatment PBC compared to patients without. Greater prediction capabilities for risk of locoregional disease progression were found in PBC collected after the start of radiotherapy compared to their pretreatment counterparts, and in individual parameters rather than cell-to-cell ratios. The most predictive PBC parameters were integrated by summation and designated as a PBC score (PBCS), which further augmented their predictive power. Patients divided according to their PBCS (high vs medium vs low) had significantly different 3-year cumulative hazards of locoregional progression (58% vs 29% vs 7%, P = 0.0017). Multivariate analysis confirmed that PBCS high (HR 12.2, 95%CI 2.0-76.3, P = 0.007) and medium (HR 5.8, 95%CI 1.2-27.7, P = 0.028) are independent indicators of locoregional progression.Conclusion: Peri-treatment PBCS can predict the long-term hazard of locoregional progression after definitive chemoradiotherapy in patients with oesophageal squamous cell carcinoma.
LncRNA ZFAS1 contributed to irradiation resistance in nasopharyngeal carcinoma by inhibiting hsa-miR-7-5p/ENO2
Authors: Peng Jiaojiao , Liu Feng , Zheng Hong , Wu Qi , Liu Shixi 
Published: March 2020

Abstract
Background: In our previous research, we found that lncRNA ZFAS1 could promote nasopharyngeal carcinoma by inhibiting its downstream target axis. But we hadn’t shown whether ZFAS1 had association with irradiation resistance of NPC. In this study, we aimed to study the role of ZFAS1 in irradiation resistance of nasopharyngeal carcinoma. Methods: Bioinformatics analysis was first conducted to identify the potentially significant gene that participated in radio resistance of nasopharyngeal carcinoma. qRT-PCR was used to detect the expression of ZFAS1, miR-7-5p and ENO2 mRNA. The location of ZFAS1 was measured in cell fractions. The relationship between ZFAS1, miR-7-5p and ENO2 mRNA was validated by luciferase reporter assay and RNA pull down. Edu assay and flow cytometric apoptosis assay were conducted to observe how ZFAS1, miR-7-5p and ENO2 affected nasopharyngeal carcinoma proliferation and apoptosis under irradiation. Results：ZFAS1 was upregulated in nasopharyngeal carcinoma, which was associated with radio resistance. ZFAS1 strengthened the ability of irradiation resistance in nasopharyngeal carcinoma. ZFAS1 acted on miR-7-5p to promote ENO2 upregulation, thereby promoting the irradiation resistance. Conclusion: ZFAS1 sponged miR-7-5p to further affect ENO2 expression to augmenting the irradiation resistance in nasopharyngeal carcinoma.