bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonates With Urinary Tract Infection
Authors: Hernández-Bou Susanna , Trenchs Victoria , Cano Iván , Girona Mònica , Luaces Carles 
Published: May 2020

Background:
Our objectives were to determine the prevalence of and to identify risk factors for coexisting bacterial meningitis (BM) in neonates with urinary tract infection (UTI).

Methods:
A cross-sectional study was conducted at pediatric emergency department of a tertiary teaching hospital from 2001 to 2017. Infants <29 days of age with UTI (≥10,000 colony-forming units/mL of a single pathogen from a catheterized specimen in association with positive urinalysis) were included. Definite BM was defined as growth of a single bacterial pathogen from a cerebrospinal fluid (CSF) sample and probable BM as (1) positive blood culture with CSF pleocytosis and treatment consistent with BM or (2) antibiotic pretreatment before lumbar puncture, CSF pleocytosis and treatment consistent with BM. Univariate testing was used to identify possible risk factors associated with BM. Receiver operating characteristics curves were constructed for the laboratory markers associated with BM.

Results:
Three hundred seventy-one infants were included. Five [1.3%; 95% confidence interval (CI): 0.6%–3.1%] had BM: 4 definite BM and 1 probable BM. Risk factors detected for BM were classified as not being well-appearing and a procalcitonin value ≥0.35 ng/mL [sensitivity of 100% (95% CI: 56.6%–100%) and negative predictive value of 100% (95% CI: 96.1%–100%)].

Conclusions:
Coexisting BM occurs uncommonly in neonates with UTI. Well-appearing neonates with UTI and procalcitonin value <0.35 ng/mL were at very low risk for BM; avoiding routine lumbar puncture in these patients should be considered.
Scale for Measuring Role Strain in Women With Diabetes
Authors: Huang Chiu-Ling , Chen Shi-Yu , Hsu Hui-Chun , Wang Ruey-Hsia 
Published: May 2020

Background
Women with diabetes (type 1 and type 2) have excessive risk of developing cardiovascular disease compared with men with diabetes, so optimizing diabetes control is crucial for women to reduce this risk. Women with diabetes experience role strain, and a scale to measure role strain in the context of diabetes control could help healthcare providers improve diabetes control in women with diabetes.

Objective
The aims of the study were to develop a short-form scale for measuring role strain in Taiwanese women with diabetes and test its psychometric properties.

Methods
This study was conducted from October 2018 to May 2019 and used a cross-sectional design. Based on literature reviews and results of focus groups, a 28-item role strain scale was developed and administered to 519 women with diabetes in Taiwan. Item analysis, exploratory factor analysis, confirmatory factor analysis, concurrent validity, and reliability testing were used to examine the psychometric characteristics of the scale.

Results
A 9-item role strain scale including subscales for role guilt and role conflict, supported by exploratory factor analysis and confirmatory factor analysis, was produced. High role strain significantly correlated with high depression (r = 0.399, P < .001) and high hemoglobin A1c levels (r = 0.169, P < .001). The overall and subscale Cronbach's α ranged between 0.78 and 0.86, with test-retest reliability ranging between 0.64 and 0.81.

Conclusions
The role strain scale for women with diabetes is reliable and valid and can be used to evaluate role strain in women with diabetes.
Implementation of the Mental Health Nurse Practitioner Role in Forensic Settings: A Case Report
Authors: Paradis-Gagné Etienne , Guimond Valérie 
Published: May 2020

ABSTRACT
This is a case report about the implementation of the mental health nurse practitioner role in forensic psychiatric settings. We will present its implementation and issues encountered during this process, such as a lack of understanding of the role in staff teams, scope of practice limitations, tension stemming from the conflict between treatment and punishment approaches, and the risk of medicalization of nursing. This case report, based on the authors' experiences, represents an early contribution to research on advanced nursing practice in forensic psychiatry, an area that has yet to receive much attention in the literature.
Comparing quality of care in medical specialties between nurse practitioners and physicians
Authors: Carranza Ashley N. , Munoz Pamela J. , Nash Angela J. 
Published: May 2020

ABSTRACT

Background:
The American health care system is facing a growing health care provider shortage in primary and specialty care settings. Research has established that nurse practitioners (NPs) match or exceed their physician colleagues in providing quality care in primary care settings.

Objective:
This systematic review aimed to compare the quality of NP versus physician-led care in outpatient specialty care setting for clinical outcomes patient satisfaction.

Data sources:
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guided the literature search (CINAHL, PubMed, and Cochrane Library) and interpretation of findings. Of the 228 articles that met the inclusion/exclusion criteria, 11 were selected for further review.

Conclusions:
Studies were conducted from 1995 to 2016 across four countries and spanned 10 distinct medical specialties. As a whole, these studies demonstrated that NPs in specialty settings perform as well as physicians terms of clinical safety and positive patient outcomes. Nurse practitioners matched or exceeded their physician counterparts in patient education and satisfaction.

Implications for practice:
Nurse practitioners are a feasible option for addressing specialty care shortages. Further research should investigate whether NPs and physicians are equally prepared to provide equivalent care immediately following their respective postbaccalaureate programs. If not, studies should explore specific training duration and elements NPs require to provide equivalent care.
Physical activity is more related to adiposity in hypertensive than nonhypertensive middle-aged and older adults
Authors: Tebar William R. , Ritti-Dias Raphael M. , Saraiva Bruna T.C. , Scarabottolo Catarina C. , Canhin Daniel S. , Damato Tatiana M.M. , Aguilar Beatriz A.S. , Christofaro Diego G.D. 
Published: May 2020

Objective
Adiposity is the main risk factor for hypertension and is negatively related to physical activity. However, it is not clear if this relationship is different according to hypertension. The present study aimed to analyze the relationship of physical activity in different domains with adiposity in hypertensive and nonhypertensive adults.

Participants and methods
A sample of 843 adults (61.6% of female) was randomly selected, with a mean age of 56.6 (±18.3) years. Diagnosed hypertension and the use of medicines were self-reported. Physical activity was assessed by questionnaire and blood pressure was measured by the oscillometric device. Adiposity indicators were as follows: BMI, waist circumference, and waist-to-height ratio (WHtR).

Results
Hypertension was reported by 44.7% of sample, being higher among older-aged, obese, elevated waist circumference and WHtR, and low physical activity groups. Physical activity was negatively related to BMI (leisure-time physical activity β = −0.070, total physical activity β = −0.082), waist circumference (leisure-time physical activity β = −0.031, total physical activity β = −0.037), and WHtR (leisure-time physical activity β = −4.917, total physical activity β = −5.996) in hypertensive adults. Hypertensive adults who had obesity were more likely to be less active at leisure physical activity [odds ratio (OR) = 2.25] and in total physical activity (OR = 2.46) than hypertensive adults with normal weight. Hypertensive adults with elevated waist circumference and elevated WHtR were more likely to be less active in total physical activity than those hypertensive adults with normal values (OR = 2.34 and 3.33, respectively).

Conclusion
Leisure time and total physical activity were related to adiposity only in hypertensive adults. Higher physical activity levels could be important to adiposity control in hypertensive population.
Limited correction of lumbar lordosis in the treatment of degenerative scoliosis
Authors: Liang Yan , Tang Xiangyu , Zhao Yongfei , Song Kai , Mao Keya , Liu Haiying , Wang Zheng 
Published: May 2020

Abstract

Background:
Patients suffering from degenerative scoliosis (DS) were commonly associated with coronal and sagittal imbalance which made deformity correction surgery necessary. The study aimed to explore the efficacy and feasibility of the limited correction of lumbar lordosis (LL) in the treatment of patients with DS.

Methods:
This was a retrospective study including 58 DS patients who underwent spinal deformity correction surgery and were followed up at least 2 years between January 2013 and January 2017. According to the difference of postoperative LL, the patients were divided into 2 groups: the limited correction group: Pelvic incidence(PI)–18°≤ LL<PI–9° and the control group: PI–9°≤ LL<PI+9°. There were 31 patients in the limited group, and 27 patients in the control group. The clinical and radiographic outcomes were compared preoperatively and at the last follow-up evaluation.

Results:
There was no significant difference between the 2 groups preoperatively (P > .05). In terms of surgery, the limited group had less intra-operative blood loss and operation time (P < .05). At the last follow-up, significant differences were found in terms of LL(−38.2 ± 4.7° and -46.9 ± 4.7°), PT (18.8 ± 5.2° and 11.1 ± 3.6°), sacrum slope (33.7 ± 7.0° and 41.4 ± 6.1°) (P < .05), while there were no significant differences in terms of lumbar Cobb angle (10.5 ± 9.3°and 8.3 ± 6.7°), Oswestry Disability Index scores (25.6 ± 10.2 and 26.4 ± 12.1), and JOA scores (23.6 ± 5.2 and 22.3 ± 5.7) (P > .05).

Conclusion:
Limited correction of LL in the treatment of DS patients can achieve favorable clinical outcomes including effective Cobb angle correction with less blood loss and operative time.
The effectiveness and safety of extracorporeal shock wave lithotripsy for the management of kidney stones
Authors: Qiang Yong-chun , Guo Yu-ge , Wang Yun-qi 
Published: May 2020

Abstract

Background:
This study will assess the effectiveness and safety of extracorporeal shock wave lithotripsy (ESWL) for patients with kidney stones (KS).

Methods:
A comprehensive and systematic literature records search for studies will be conducted in MEDLINE, EMBASE, Cochrane Library, WANGFANG, VIP, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All these databases will be searched from inception to the present without language limitation. Cochrane risk of bias tool will be used to assess the methodological quality for all included studies. Statistical analysis is performed using RevMan 5.3 software.

Results:
This study will provide synthesis of current evidence of ESWL for patients with KS through assessing primary outcomes of overall stone-free rate, and secondary outcomes of mean stone size (mm), pain intensity, urinary biochemical variables, mean hospital stay (day), quality of life, and adverse events.

Conclusion:
This study will provide recommendations for the effectiveness and safety of ESWL for patients with KS, which may help to guide clinician.

PROSPERO registration number:
PROSPERO CRD42019157243.
Contrast-enhanced ultrasound evaluation of the prostate before transrectal ultrasound-guided biopsy can improve diagnostic sensitivity
Authors: Liu Guangqing , Wu Size , Huang Li 
Published: May 2020

Abstract
To conduct a STARD-compliant validity that the contrast-enhanced ultrasound (CEUS) evaluation of prostate for the improvement of positive rate of biopsy and diagnostic efficiency of prostate carcinoma (PCa).
Data of 137 patients with suspected PCa who underwent relevant examinations and treatment were reviewed, and 82 of 137 patients were finally included. The patients consisted of Group 1 (26 patients) and Group 2 (42 patients) according to which they underwent transrectal ultrasound (TRUS) biopsy selected from CEUS evaluation of the prostate and who underwent TRUS-guided biopsy directly. A systematic 12-core biopsy was performed at first, and additional 1 to 2 cores biopsy was made in the suspected target area where CEUS had showed abnormal enhancement. The assumed diagnoses were compared with pathological findings.
There were 37 patients with PCa and 31 patients with benign lesions; and 14 patients without biopsy after CEUS did not find PCa emerging in follow-up (18–47 months). The positive rates of biopsy-malignant lesions were 73.1% and 42.8% in Group 1 and Group 2, respectively. The positive rate of biopsy in Group 1 was significantly higher than that in Group 2 (P = .024). The sensitivity and accuracy of TRUS biopsy and a combination of TRUS biopsy after transrectal CEUS for the evaluation of prostate benign and malignant lesion were 60% and 66.7% (P=0.0139), and 94.4% and 88.5% (P=0.0453), respectively.
CEUS evaluation of the prostate of PSA-elevated patient before biopsy can help select target patient with high risk of PCa, reduce unnecessary biopsy, increase detection rate of PCa, and improve diagnostic sensitivity and accuracy.
Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors
Authors: Lee Chang-Hoon , Jeon So Yeon , Yhim Ho-Young , Jang Kyu Yun , Kwak Jae-Yong 
Published: May 2020

Abstract

Introduction:
After tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 were introduced for the treatment of chronic myeloid leukemia, clinical outcomes have improved dramatically. However, together with the increase in the survival rate, a more frequent occurrence of secondary malignancies has been observed as well. TKIs have been demonstrated to be a risk factor of malignancies such as non-Hodgkin lymphoma, prostate cancer, and skin cancer. However, lymphoplasmacytic lymphoma (LPL) has never been reported as a secondary malignancy after TKI treatment in chronic myeloid leukemia (CML).

Patient concerns:
An 81-year-old male patient diagnosed with CML and treated with TKIs for a long period (15 years) was admitted due to a chief complaint of abdominal pain. A large abdominal mass was detected by imaging that included computed tomography.

Diagnosis:
LPL was confirmed from biopsies after ultrasonography and sigmoidoscopy. Serum IgM level was increased and M protein and monoclonal gammopathy, IgM_kappa light chain type were detected.

Interventions:
The patient received six cycles of R-CHOP chemotherapy.

Outcomes:
After chemotherapy, he showed response. The sizes of the abdominal mass and lymph nodes decreased; moreover, serum M protein and IgM levels decreased, as well.

Conclusion:
Herein, for the first time, we describe a patient who developed LPL as a secondary malignancy after administration of TKIs for the treatment of CML. Our observations indicate the importance of awareness of this secondary malignancy that can develop in CML patients treated with TKIs.
Moxibustion for treating knee osteoarthritis
Authors: Wang Xue , Jiang Yunfeng , Xiong Jun , Yuan Ting , Yang Jun , Zhou Xiaohong , Liao Kai , Xu Lingling 
Published: May 2020

Abstract

Background:
Knee osteoarthritis (KOA) is a significant health issue because it causes pain and functional limitation. Many studies have reported that moxibustion, a treatment in traditional Chinese medicine, is effective in treating KOA. The aim of this overview is to synthesize and assess the reliability of evidence generated from these systematic reviews of the effectiveness of moxibusition for KOA.

Methods:
This is a protocol for a systematic overview of reviews. We will search 7 databases: PubMed, Embase, Cochrane Library, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, WangFang Database, Chinese Scientific Journal Database from their inception to April 2020. We will consider systematic reviews and meta-analysis of randomized controlled trials evaluating the effectiveness of moxibustion for KOA. Independent reviewers will sift, perform data extraction in duplicate, and assess the quality of the reviews using the Change MeaSurement Tool to Assess Systematic Reviews-2 to Assessment of Multiple Systematic Reviews-2 and the Preferred Reporting Item for Systematic Review and Meta-Analysis statement. The outcomes of interest include: quality of life, knee function, and pain relief outcomes prioritized in the individual reviews. The evidence will be synthesized where appropriate by patient subgroups, intervention type, context, and outcome. Revman 5.3 software will be used to conduct meta-analysis and calculate the risk ratio for dichotomous data. Weighted mean difference or standard mean difference will be calculated for continuous data. The quality of evidence was assessed according to Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considering the methodological quality of the randomized controlled trials and meta-analysis.

Results:
The results of this study will be published in a peer-reviewed journal.

Conclusions:
We expect to compile evidence from multiple systematic reviews of symptomatic improvement in patients with KOA in an accessible and useful document.

Trial registration number:
CRD42019141029 in PROSPERO 2019.
Indices of left ventricular voltage on electrocardiogram are closely associated with serum cardiac troponin I levels in normotensive Japanese individuals
Authors: Mizoguchi Tatsuya , Sugiura Tomonori , Dohi Yasuaki , Takase Hiroyuki , Fujii Satoshi , Seo Yoshihiro , Ohte Nobuyuki 
Published: May 2020

Abstract
The high-sensitivity cardiac troponin I (hs-cTnI) in serum can increase due to an increase in left ventricular (LV) overload in individuals with hypertension. Since LV voltage on an electrocardiogram (ECG) reflects LV load, it is possible that LV voltage is closely associated with hs-cTnI in individuals without hypertension. This study investigated the association between LV voltage indices and serum hs-cTnI levels in normotensive Japanese individuals.
Subjects who visited the Enshu Hospital for a health check-up were screened for their eligibility. Subjects with renal dysfunction, cancer, active inflammatory disease, or a history of cardiovascular events were excluded, as were subjects with obvious ST segment or T wave abnormality, Wolff–Parkinson–White syndrome, pacemaker implantation, or frequent arrhythmia in the ECG. Exclusion of individuals with hypertension left 803 subjects (54.8 ± 11.3 years) for final inclusion. The R wave voltage in lead V5 (RV5 voltage), the Sokolow–Lyon voltage (a sum of the QRS wave (a complex wave consists of Q, R, and S wave) of the S wave voltage in lead V1 and the R wave voltage in lead V5), and the Cornell product (a product of QRS duration and QRS voltage) were evaluated by ECG as LV voltage indices. Laboratory measurements included serum hs-cTnI levels. Possible associations between indices of LV voltage on ECG and serum hs-cTnI levels were cross-sectionally investigated in the normotensive subjects.
The median values [interquartile range] of hs-cTnI and BNP were and 2.1 [1.4–3.0] and 13.8 [7.7–24.9] pg/mL, respectively. Multivariate regression analysis identified that the levels of hs-cTnI, but not BNP, were significantly associated with RV5 voltage (β 0.090, P = .0087), Sokolow–Lyon voltage (β 0.112, P = .0009), and Cornell product (β 0.101, P = .039) after adjustment for possible confounding factors. Moreover, the RV5 voltage, Sokolow–Lyon voltage, and Cornell product were significantly associated with the hs-cTnI levels after adjustment for possible confounding factors including ECG findings (β 0.109, P = .0075; β 0.125, P = .0010; and β 0.096, P = .0116, respectively).
Indices of LV voltage in ECG had close associations with serum hs-cTnI levels in normotensive subjects. These findings support that the ECG findings of LV voltage have significant associations with slight myocardial micro-damage even in normotensive subjects.
Effectiveness of the integrated care model Salut+Social in patients with chronic conditions
Authors: Gavaldà-Espelta Ester , del Mar Lleixà-Fortuño Maria , Baucells-Lluis Jordi , Ferré-Ferraté Maria , Mora-López Gerard , Tomàs-Navarro Begoña , Curto-Romeu Claudia , Lucas-Noll Jorgina , Aguilar Martin Carina , Gonçalves Alessandra Queiroga , Ferré-Grau Carmen 
Published: May 2020

Abstract

Introduction:
Integrated care models aim to provide solutions to fragmentation of care by improving coordination. This study will evaluate the effectiveness of a new integrated care model (Salut
+
Social), which will promote the coordination and communication between social and healthcare services in southern Catalonia (Spain) to improve quality of life, adherence to treatment and access to medical services for patients with chronic conditions, and also to reduce caregiver burden. Additionally, we will evaluate the experience of caregivers, health professionals and social workers with the new model implemented.

Methods and analysis:
A clinical trial using mixed methodology will be carried out. The intervention consists of improving the coordination between the social and healthcare sectors during a 6-month period, by means of information and communication technology (ICT) tools that operate as an interface for the integrated care model. The study subjects are primary care patients with chronic health and social conditions that can benefit from a collaborative and coordinated approach. A sample size of 141 patients was estimated. Questionnaires that assess quality of life, treatment adherence, medical service and caregiver burden will be used at baseline and at 6, 9, and 12 months after the beginning of the study. The principal variable is quality of life. For statistical analysis, comparisons of means and proportions at different time points will be performed. A discussion group and semi-structured interviews will be conducted with the aim of improving the care model taking into account the opinions of professionals and caregivers. A thematic content analysis will be carried out.

Ethics and dissemination:
This study protocol has been approved by the Clinical Research Ethics Committee of the Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (code P17/100). Articles will be published in international, peer-reviewed scientific journals.

Trial registration:
Clinical-Trials.gov: NCT04164160.