bluuebunny/crossref_metadata_2025_split huggingface dataset:
10-Year Mortality Pattern Among Cancer Patients in Lagos State University Teaching Hospital, Ikeja, Lagos
Authors: Fatiregun Omolara Aminat , Bakare Omowunmi , Ayeni Sunday , Oyerinde Adebowale , Sowunmi Anthonia C. , Popoola Abiodun , Salako Omolola , Alabi Adewumi , Joseph Adedayo 
Published: November 2020

BackgroundGlobally, cancer is a major leading health problem with an estimated 10 million incidences and 6 million cancer deaths annually. In Nigeria, an estimated 72,000 cancer deaths occur annually, and 102,000 new cases are diagnosed from its population of 200 million people. These are, however, estimates, it is necessary to document the yearly trends and patterns of cancer mortality with regards to the different regions in the country.Methodologywe conducted this study at the Lagos State University Teaching hospital (LASUTH), Ikeja, Lagos to document mortality patterns from 2009 to 2018. Data extracted included those from the patient’s case notes, admission and death registers, and death certificates. we also had records from the hospital records department and medical wards. We then documented cancer mortality over the study period.ResultsA total number of 6,592 deaths were recorded over ten years, and 1,133 cases were cancer-related deaths. This number puts the percentage of cancer-related deaths at 17.2%. Male patients accounted for 54.0%, and female patients are 46.0%. Breast cancer accounted for the highest mortality, followed by prostate cancer. The highest number of deaths were recorded in 2010 at 821, followed by 2011 at 799, 2015 at 780, and the least in 2017 at 513. There is also a significant general increase in odds of mortality with an increase in decades of life.ConclusionThis study shows that about one in five deaths, over the last ten years, from this tertiary institution, is related to a cancer diagnosis. Even though a yearly decline in the number of cancer deaths was noticed, probably due to increased awareness and governmental intervention, the percentage still remains high.
NTRK Fusions and TRK Inhibitors: Potential Targeted Therapies for Adult Glioblastoma
Authors: Wang Yuekun , Long Piaopiao , Wang Yu , Ma Wenbin 
Published: November 2020

IntroductionGlioblastoma multiforme (GBM) is the most common primary central nervous (CNS) system malignancy with a poor prognosis. The standard treatment for GBM is neurosurgical resection, followed by radiochemotherapy and adjuvant temozolomide chemotherapy. Predictive biomarkers, such as methylation of the promoter region of the O6-methylguanine DNA methyltransferase (MGMT) gene, can successfully distinguish subgroups with different prognosis after temozolomide chemotherapy. Based on multiomics studies, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), BRAF V600E mutation, neurotrophic tyrosine receptor kinase (NTRK) fusions and other potential therapy targets have been found.MethodsWe have reviewed the preclinical and clinical evidence for NTRK fusions and TRK inhibitors therapy in cancers with NTRK fusions in pan-cancer and gliomas.ResultsSeveral NTRK1/2/3 fusions have been reported in GBM and preclinical studies have proven that NTRK fusions are potential driver mutations in some high-grade gliomas. Tropomyosin receptor kinase (TRK) inhibitors have shown efficacy as targeted therapies for extracranial tumors with NTRK fusions in recent clinical trials, with potential CNS tolerability and activity. However, whether NTRK gene fusions can affect survival status, the efficacy and resistance of TRK inhibitors in GBMs are lacking high-level evidences.ConclusionsFor GBM patients, NTRK fusions and TRK inhibitors are potential target therapy strategy but remain biological mechanism and clinical significance unclarified. More clinical data and future clinical trials are needed to provide more evidence that supports targeted therapy for GBM with NTRK fusions.
Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases
Authors: Afzal Saira , al-Rashida Mariya , Hameed Abdul , Pelletier Julie , Sévigny Jean , Iqbal Jamshed 
Published: November 2020

Ectonucleoside triphosphate diphosphohydrolases (NTPDases) are ectoenzymes that play an important role in the hydrolysis of nucleoside triphosphate and diphosphate to nucleoside monophosphate. NTPDase1, -2, -3 and -8 are the membrane bound members of this enzyme family that are responsible for regulating the levels of nucleotides in extracellular environment. However, the pathophysiological functions of these enzymes are not fully understood due to lack of potent and selective NTPDase inhibitors. Herein, a series of oxoindolin hydrazine carbothioamide derivatives is synthesized and screened for NTPDase inhibitory activity. Four compounds were identified as selective inhibitors of h-NTPDase1 having IC50 values in lower micromolar range, these include compounds 8b (IC50 = 0.29 ± 0.02 µM), 8e (IC50 = 0.15 ± 0.009 µM), 8f (IC50 = 0.24 ± 0.01 µM) and 8l (IC50 = 0.30 ± 0.03 µM). Similarly, compound 8k (IC50 = 0.16 ± 0.01 µM) was found to be a selective h-NTPDase2 inhibitor. In case of h-NTPDase3, most potent inhibitors were compounds 8c (IC50 = 0.19 ± 0.02 µM) and 8m (IC50 = 0.38 ± 0.03 µM). Since NTPDase3 has been reported to be associated with the regulation of insulin secretion, we evaluated our synthesized NTPDase3 inhibitors for their ability to stimulate insulin secretion in isolated mice islets. Promising results were obtained showing that compound 8m potently stimulated insulin secretion without affecting the NTPDase3 gene expression. Molecular docking studies of the most potent compounds were also carried out to rationalize binding site interactions. Hence, these compounds are useful tools to study the role of NTPDase3 in insulin secretion.
The 100 Top-Cited Studies on Neuropsychology: A Bibliometric Analysis
Authors: Zhang Yang , Xiong Ying , Cai Yujia , Zheng Linli , Zhang Yonggang 
Published: November 2020

ObjectiveThe present study aimed to identify and analyze the bibliometric characteristics of the 100 top-cited studies on neuropsychology.MethodsWe searched the Web of Science Core Collection database to collect studies on neuropsychology from inception to 31st December 2019. Two authors independently screened the literature and extracted the data. Statistical analyses were performed using R software.ResultsThe 100 top-cited articles were cited a total of 166,123 times, ranging from 736 to 24,252 times per article. All of the studies were published from 1967 to 2014 in 47 journals. Neuropsychologia had the highest number of articles (n = 17), followed by Neurology (n = 8). The top three most productive countries were the USA (n = 60), England (n = 13), and Canada (n = 8). Eight authors contributed the same number of studies as the first author (n = 2) or corresponding author (n = 2). The most productive institute was the University of California (n = 9), followed by the University of Pennsylvania (n = 4). Of the 100 top-cited publications, 64 were original articles, and 36 were reviews. The top three Web of Science categories were clinical neurology (n = 28), behavioral sciences (n = 19), and psychiatry (n = 11).ConclusionThis study provides insight into the impact of neuropsychology research and may help doctors, researchers, and stakeholders to achieve a more comprehensive understanding of trends and most influential contributions to the field, thus promoting ideas for future investigation.
Family Farming and Commercialization: the case of the covered fair in Nova Xavantina-MT
Authors: Silva L. L. , Maia A. H. , Carlos T. , Santos L. N. S. 
Published: November 2020

This study aimed to evaluate the experiences of family agriculturists who sell their products in the Covered Fair of Nova Xavantina - MT, from the different strategies used by them, their problems and prospects in relation to income generation and maintenance of families . We surveyed 14 familiar producers and 14 consumers. These numbers have not been defined by statistical criteria, which is characterized by a search combining a quantitative and qualitative approach. The instruments used for data collection consisted of questionnaires, direct observation and interviews. By this research it could be seen that the Covered Fair is an important space of conviviality, trade and consumption, however, this place is still little appreciated by the population and producers. The lack of infrastructure and the stiffness of supervision does not bring attractive to many farmers in the municipality and this is directly reflected in the marketing and purchase of products from family farms, important sector in terms of economic and social development. Thus, public policies for production, consumption and trade are essential for greater inclusion of family farmers in the municipality of Nova Xavantina and region.
From the history of the formation of the Far Eastern Scientific Center of the USSR Academy of Sciences
Authors: БОГАТОВ В.В. 
Published: November 2020

Анализируются этапы формирования Дальневосточного научного центра АН СССР. Впервые приводятся сведения о проектировании комплекса зданий Дальневосточного филиала АН СССР во Владивостоке.
The stages of formation of the Far Eastern Scientific Center of the USSR Academy of Sciences are analyzed. For the first time, information is provided on the design of a complex of buildings for the Far Eastern Branch of the USSR Academy of Sciences in Vladivostok.
Study Literature Review: Pengaruh Aromaterapi Terhadap Kualitas Tidur, Kualitas Hidup, Kelelahan & Kecemasan Pada Pasien Diabetes Melitus
Authors: Ariska Mega , Faridah Ida 
Published: November 2020

Background: Diabetes mellitus is an incurable disease but can be controlled by controlling blood sugar levels and improving sleep quality and quality of life in people with diabetes. The prevalence of diabetes mellitus in Banten province has increased in 2013 by 1.3%, while in 2018 it was 2.2%. Purpose: The purpose of this literature review is to determine the effectiveness of aromatherapy in patients with diabetes mellitus. Research Methods: The method used to analyze data is Systematic Literature Review. Search for articles using google scholar database, PubMed, Research Gate, and Elsevier and get eight relevant articles and analyzed using the simplified thematic approach. The article selection process is done using a PRISMA flow diagram. Results: lavender aromatherapy, bitter orange and sandalwood / sandalwood significantly affect changes in sleep quality, quality of life, anxiety and fatigue in patients with type 1 and 2 diabetes mellitus with a combination of massage therapy and foot exercises. Thus, it can be concluded that aromatherapy is effective on sleep quality, quality of life, anxiety and fatigue in patients with type 1 and 2 diabetes mellitus. Suggestion: Therefore, the use of aromatherapy can be recommended as a non-pharmacological intervention that can affect sleep quality in patients with type 2.

Keywords: Aromatherapy, Sleep Quality, Quality Of Life, Fatigue, Anxiety, Diabetes Mellitus
Literature: 2015 – 2020
Review of the Danian vertebrate fauna of southern Scandinavia.
Authors: Adolfssen Jan S. , Milàn Jesper , Friedman Matt 
Published: November 2020

The vertebrate fauna in the Danian deposits of Denmark and southern Sweden is reviewed. Remains of sharks and bony fishes are widely distributed but not common in the Danian limestones, with the exception of the K/Pg-boundary clay, the Fiskeler Member, at the UNESCO World Heritage Site Stevns Klint, which can include substantial quantities of shark teeth and fragments of bony fishes.

Articulated remains of bony fishes are known from the Fiskeler Member at Stevns Klint and the København Limestone Formation in the Limhamn quarry. Sharks are only found as isolated teeth and rare isolated vertebrae. The gavialoid crocodylian Thoracosaurus is represented by a complete skull and associated postcranial material and an additional jaw fragment from the Limhamn quarry.

Remains of a crocodylian skull, a cervical vertebra, a limb bone and isolated teeth have been found in the Faxe quarry, and a single possibly alligatorid tooth is known from the basal conglomerate of the Lellinge Greensand Formation from now closed exposures below Copenhagen.

Fragmentary turtle material has been found in the face and Limhamn quarries and in the København Limestone in Copenhagen, and bird remains are exclusively known from the Limhamn quarry. Despite the fragmentary nature of many of the finds, the total picture of the vertebrate fauna of southern Scandinavia is quite diverse comprising four classes, 23 orders, 41 families and 54 identifiable genera of which most can be identified to species level.
Anopolenus henrici Salter, a middle Cambrian (Drumian) centropleurid trilobite from the Alum Shale Formation of Scandinavia
Authors: Weidner Thomas , Ebbestad Jan Ove R. 
Published: November 2020

Centropleurid trilobites include five genera of which Centropleura Angelin, Anopolenus Salter, Clarella Howell and Luhops Šnajdr are known from eight species in the traditional middle Cambrian (Miaolingian Series, Drumian Stage) of Sweden and Denmark (Bornholm). Beishanella Xiang & Zhang has not been recorded in Scandinavia so far, and no centropleurids have been reported from Norway. Of these taxa, only Centropleura is common in Scandinavia. Two pygidia previously identified as Centropleura sp. and Anopolenus sp. from erratics in Germany and Bornholm, respectively, as well as a new pygidum from Scania in Sweden are here identified as Anopolenus henrici Salter. Elsewhere, the species is known from Wales, Avalonian Canada, Siberia, Alaska, and Sardinia, occurring in the A. atavus and P. punctuosus zones (the former in Siberia only). The presence of this species increases the known diversity of Centropleuridae in Scandinavia and is important for correlation between Baltica and Avalonia.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI NILAI PERUSAHAAN
Authors: Nuradawiyah Annisa , Susilawati Susi 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui pengaruh Ukuran Perusahaan, Profitabilitas, Struktur Modal dan Harga Saham terhadap Nilai Perusahaan. Populasi yang digunakan dalam penelitian ini adalah perusahaan Indeks LQ45 yang terdaftar di Bursa Efek Indonesia tahun 2014-2018 dengan pemilihan sampel menggunakan teknik purposive sampling, dari 45 sampel terpilih 21 perusahaan sebagai sampel. Analisis yang digunakan adalah analisis regresi data panel. Dari hasil pengujian menunjukkan bahwa ukuran perusahaan berpengaruh negatif dan signifikan terhadap nilai perusahaan, Return On Assets (ROA) berpengaruh positif dan signifikan terhadap nilai perusahaan, Net Profit Margin (NPM) dan Earning Per Share (EPS) berpengaruh negatif dan signifikan terhadap nilai perusahaan, Debt to Asset Ratio (DAR) dan Debt to Equity Ratio (DER) tidak berpengaruh signifikan terhadap nilai perusahaan, harga saham berpengaruh positif dan signifikan terhadap nilai perusahaan. Tingginya harga saham menunjukan bahwa perusahaan mampu memberikan kesejahteraan bagi para pemegang saham, sehingga banyak investor yang bersedia untuk membeli saham perusahaan tersebut dan akan meningkatkan nilai perusahaan.
A College of Nursing's Upward Spiral During a Global Pandemic
Authors: Mariani Bette , Havens Donna S. , Metz Sarah 
Published: November 2020

Background:
In March 2020, COVID-19 forced institutions of higher education, faculty, staff, and students to transition to emergency remote learning. This unprecedented time provided the opportunity to reenvision the delivery of nursing education and operation of the college of nursing, using the principles of the four Cs of interorganizational partnering as a guide supported by positive organizational scholarship.

Method:
The Villanova University Fitzpatrick College of Nursing designed and implemented strategies to provide seamless learning opportunities for students in undergraduate and graduate nursing programs, while providing necessary support and future planning for the upcoming academic year.

Results:
Online and virtual learning platforms integrated into curricula assisted students to meet course objectives and program outcomes. Strategies for effective communication, collegiality, and collaboration within and among the college, university, and nursing community served as mechanism for innovation.

Conclusion:

Communication, cooperation, coordination, and collaboration, along with positive organizational strategizing and support contributed to a successful transition during the COVID-19 pandemic; many of the approaches implemented during the emergency transition will continue into the future.

[
J Nurs Educ.
2020;59(12):675–682.]
An Innovative Virtual Poster Session for Doctor of Nursing Practice Student Project Presentations
Authors: Diegel-Vacek Lauren , Carlucci Melisa 
Published: November 2020

Background:
The COVID-19 pandemic closed university campuses across the country. Nurse educators were challenged to develop innovative solutions for students to complete course requirements. The on-campus poster session used by a college of nursing as a scholarly forum for dissemination of all Doctor of Nursing Practice (DNP) student final projects was cancelled due to the pandemic.

Method:
Nurse educators developed and implemented an interactive, synchronous virtual session using the Zoom Video Communications platform.

Results:
Twelve virtual sessions were held, and 73 students presented DNP project posters. More than 150 students and faculty attended the virtual poster sessions. Students and faculty had positive feedback regarding the virtual format. Student presentations were academically rigorous, and audiences engaged in robust discussion with DNP students.

Conclusion:

The virtual platform was successfully used for an interactive presentation by DNP student and nursing faculty participants. This format may be especially valuable for use of scholarship dissemination by distance learning programs.

[
J Nurs Educ
. 2020;59(12):697–700.]
Efficacy of bicarbonate therapy for adults with cardiac arrest
Authors: Wongtanasarasin Wachira , Srisurapanont Karan 
Published: November 2020

OBJECTIVES:
Because the benefits of bicarbonate therapy remain unclear, it is not routinely recommended for the cardiopulmonary resuscitation (CPR) given to individuals with cardiac arrest (CA). This study aims to evaluate the clinical benefits of bicarbonate therapy in adults with CA.

METHODS:
Without any language restriction, we searched PubMed/MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL from the inception until April 30, 2020. We performed hand-search to identify the relevant trials included in previous meta-analyses. Included studies were randomized controlled trials (RCTs) comparing bicarbonate and placebo treatment in adults with CA. Two authors independently assessed the trial risk of bias. The primary outcome was the survival to hospital admission. The secondary outcomes included the return of spontaneous circulation, the survival to hospital discharge, and the neurological outcome at discharge. We calculated the odds ratios of those outcomes using the Mantel-Haenszel model and assessed the heterogeneity using the I2statistic.

RESULTS:
Our searches found 649 unduplicated studies. Of these, three RCTs involving 1344 patients were included in the meta-analysis. The trial risk of bias ranged between fair and poor, mainly due to no blindness of outcome assessment and the selective reports of outcomes. Bicarbonate therapy showed no significant improvement in the survival to hospital admission (odds ratio [OR] 0.96; 95% confidence interval [CI] 0.73–1.25). Subgroup analysis in those receiving prolonged CPR showed a similar result (OR 0.88; 95% CI 0.10–8.01). No study reported the predefined secondary outcomes.

CONCLUSION:
For both acute and prolonged CPR, bicarbonate therapy might not show benefit to improve the rate of survival to hospital admission in adults with cardiac arrest.
Soil-forming processes in profile textural-differentiated forest soils of the Cis-Carpathian region, Ukraine
Authors: Yamelynets Taras , Pankiv Zinoviy , Malyk Stepan 
Published: November 2020

Throughout the history of soil science development, one of the most controversial issues was the explanation of the genesis of the profile textural-differentiated soils influenced by forest vegetation and climate conditions within the Cis-Carpathian region, Ukraine. Scientists' views on the formation of the eluvial-illuvial, namely granulometric content, and profile differentiation have been and remain ambiguous due to the contradictory criteria of diagnosing the processes of eluvial soil degradation (lessivage, podzolization, eluvial-gleying process) and the almost similar results of these processes. The complexity and ambiguous interpretation of the genetic nature of the profile textural-differentiated soils of the Cis-Carpathian region necessitates the development of clear diagnostic criteria for revealing their genetic nature. The purpose of the work is to establish the diagnostic criteria of elementary soil-forming processes in profile textural-differentiated forest soils of the Cis-Carpathian region based on the analysis of data on soil properties previously collected by the authors.
It has been established that in sod-podzolic soils formed under forest, the main profile-forming elementary process of soil formation is podzolization, which is characterized by the negative values of the eluvial-accumulative coefficients and the coefficient of change of the silicate part for the upper three horizons. The processes of lessivage and segregation are of little intensity in this type of soils. The main profile-forming elementary processes of soil formation in brown-podzolic soils (Neocambic Gleyic Retisols) are lessivage and inner soil argillization with little podzolization, the eluvial-gleying process and segregation effects.
Keywords: forest soils, argillanes, neoplasms, ortsteins, podsolization, elementary soil-forming processes, Cis-Carpathian region
Microhabitat characteristics of brown bear den areas
Authors: Ugarkovic Damir , Fabijanić Nera , Tomljanović Kristijan , Krmpotić Davor , Kelava Ugarković Nikolina 
Published: November 2020

The aim of this study was to determine the microhabitat, relief and forest structure characteristics of brown bear (Ursus arctos L.) cave dens and other types of dens in the North Dinarides (Velebit Nature Park) in Croatia. In total, 63 dens were identified, consisting of 89% cave dens and 11% other den types (nest dens 6%, stump dens 3%, trunk dens 2%). In the 20-meter radius around each den, the microhabitat, relief and structural characteristics were recorded, including altitude, slope, exposition, rockiness, forest developmental stage, canopy density, tree height, forest site index, tree basal area, and tree species composition. Based on altitude, the climatic category was determined according to the Köppen climate classification. Most cave dens (62%) were in the temperate climate, at altitudes between 900 and 1,100 m, with a southern exposition and slope class between 30 to 60%. The dens situate in partial canopy density of the third forest site index with tree heights between 16 and 20 m and without forest degradation. Slopes and tree heights were lower (p < 0.019) in cave den areas in comparison to other den types.
Keywords: cave dens, microhabitat, forest structure, North Dinarides, Velebit Nature Park