bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between plasma furin and cardiovascular events after acute myocardial infarction
Authors: Liu Zhi-wei , Ma Qiang , Liu Jie , Li Jing-Wei , Chen Yun-Dai 
Published: December 2020

Abstract
Background: Furin is the key enzyme to cleave pro-BNP and plays a critical role in the cardiovascular system through its involvement in the lipid metabolism, blood pressure and formation of atheromatous plaques. NT-proBNP and recently corin, which is also a key enzyme to cleave pro-BNP, have been approved as predictors of prognosis after acute myocardial infarction (AMI). We here conducted this cohort study to investigate the relationship between plasma furin and the prognosis outcome in patients after AMI. Methods: We enrolled 1100 AMI patients and measured their plasma furin concentration. The primary endpoint was the major adverse cardiac events (MACE), a composite of cardiovascular (CV) death, non-fatal myocardial infarction or non-fatal stroke. The association of plasma furin concentration with AMI outcomes was explored by using Kaplan–Meier curve and multivariate Cox regression analysis. Results: Our results showed that slight increase of mean cTNT in patients with higher furin concentration (P=0.016). Over a median follow-up of 31 months, multivariate Cox regression analysis suggested that plasma furin was not associated with MACE (HR: 1.01; 95% CI: 0.93-1.06; P=0.807) after adjustment for potential conventional risk factors. However, plasma furin was associated with non-fatal MI (HR: 1.09; 95% CI: 1.01-1.17; P=0.022) after fully adjustment. Subgroup analysis indicated no relationship between plasma furin and MACE in different subgroup populations.Conclusions: Our study demonstrated that plasma furin was not associated with risk of MACE and may not be used as a predictor of poor prognosis after AMI. But higher levels of plasma furin may be associated with higher risk of non-fatal MI.
Favorable outcomes of chidamide combined with cyclophosphamide, epirubicin, vindesine, prednisone, and etoposide (C-CHOEP) in patients with newly diagnosed peripheral T-cell lymphoma
Authors: Wei Chong , Zhang Yan , Wang Wei , Zhang Lu , Mao Yueying , Feng Jun , Cai Huacong , Zhang Wei , Zhou Daobin 
Published: December 2020

Abstract
Background: Outcomes with CHOP (cyclophosphamide, epirubicin, vindesine, and prednisone) or CHOP-like regimens are poor in most types of peripheral T-cell lymphomas (PTCLs). In this study, we investigated whether the combination of chidamide with CHOEP (cyclophosphamide, epirubicin, vindesine, etoposide, and prednisone) regimen (C-CHOEP) was superior to CHOEP and GDP-ML (gemcitabine, cisplatin, dexamethasone, methotrexate, and pegaspargase) regimen for previously untreated PTCL patients. Methods: This is a single-center retrospective study conducted at Peking Union Medical College Hospital (PUMCH). Between January 2012 and August 2019, a total of 94 newly diagnosed PTCL patients were included in this study, including 34 patients from the C-CHOEP phase 2 trial, 34 patients treated with CHOEP regimen matched to those in the C-CHOEP group, and 26 patients from a previous phase 2 trial of GDP-ML therapy. Results: The complete remission rate of patients in the C-CHOEP group was significantly higher than that of GDP-ML and CHOEP group (55.9% vs. 32.0% and 29.4%, p = 0.047), with an overall response rate of 82.4% vs. 64.7%, and 72.0%, respectively (p = 0.244). The overall survival of patients in the C-CHOEP group was significantly superior than that of the GDP-ML and CHOEP group, with 1- and 3- year OS rates of 80.9% and 73.5% in the C-CHOEP group vs. 67.4% and 36.9% in the GDP-ML group, and 64.6% and 48.9% in the CHOEP group (p = 0.048). Progression-free survival (PFS) was also improved with median PFS of 19.8 months in the C-CHOEP group vs. 6.6 and 8.1 months in the GDP-ML and CHOEP group. The most common adverse events were hematologic toxicities. Grade 3-4 neutropenia and febrile neutropenia occurred in 58.8% and 20.6% of patients in the C-CHOEP group with no significant difference compared with the CHOEP group. Conclusion: Our study suggested that C-CHOEP therapy was superior to CHOEP and GDP-ML therapy for newly diagnosed PTCL patients as shown by a significant improvement of CR rate and OS with a favorable safety profile.Trial registration: The study of C-CHOEP regimen is registered at ClinicalTrials.gov on December 2nd 2016 (NCT02987244). The study of GDP-ML regimen is registered at Chinese Clinical Trial Registry on March 30th 2012 (ChiCTR-ONC-12002055).
Recurrent ischemic stroke in patients with atrial fibrillation: frequency, heterogeneity, prevention
Authors: Geraskina L. A. , Alieva M. M. , Fonyakin A. V. , Maximova M. Yu. , Garabova N. I. , Burzhunova M. G. 
Published: December 2020

Introduction. For the prevention of recurrent ischemic stroke (IS) in patients with atrial fibrillation (AF), oral anticoagulants (OAC) are considered a priority. The comorbidity of AF patients raises a discussion about the non-alternative feasibility and exceptional clinical efficacy of OAC. The validity of the choice of a specific antithrombotic agent can be assessed using a dynamic assessment of the causes of the first and recurrent stroke in patients with AF.Aim. To assess the frequency recurrent IS and quality of medicament prevention therapy in patients with AF depend on heterogeneity of stroke leading pathogenetic mechanism.Materials and methods. The data from the register of 200 patients with IS and AF were analyzed. 55 (27.5%) patients suffered recurrent IS (24 (43,6%) men, 31 (56,4%) women, mean age 72,3 ± 10,2 years). The pathogenetic subtype of recurrent IS was determined, including a retrospective assessment of the pathogenetic subtype of a previous IS. We studied the presence and nature of antithrombotic therapy (ATT) preceding a second stroke.Results. The first IS was due to cardiogenic embolism in 36.4% of patients, the atherothrombotic subtype occurred in 18.2%, and the lacunar subtype in 34.5% of patients. Embolic stroke from an undetermined source (ESUS) - in 10.9% of patients. OACs were prescribed only to 31.7% of patients, antiplatelet agents - to 14.6% of patients, 53.7% of patients did not receive ATT. The leading pathogenetic subtype of recurrent stroke was cardiogenic embolism (70.7%), the frequency of lacunar stroke decreased (4.9%), and the frequency of atherothrombotic stroke remained unchanged. In 14 patients with recurrent stroke, AF was first detected, including all patients with ESUS.Conclusion. The proportion of recurrent stroke in patients with AF is 27.5%. Compared with the first stroke, recurrent stroke in patients with AF is characterized by an increase in the proportion of cardiogenic embolism up to 70.7%, which is due to the insufficient prescription of OAC, which must be recommended, including for patients with non-cardioembolic subtypes of stroke.
Comparison of Ropivacaine-Fentanyl with Bupivacaine-Fentanyl for Labour Epidural Analgesia
Authors: Kulkarni Kalpana , Patil Rahul 
Published: December 2020

Background:
Bupivacaine with opioid is commonly used for labour epidural analgesia. Ropivacaine is considered as an alternative to bupivacaine due to its lower cardiovascular complications. However, there is a controversy regarding the efficacy of these drugs as some studies suggest equivalent action, whereas others report that ropivacaine produces less motor blockade. The study aimed to compare the effect of ropivacaine-fentanyl and bupivacaine-fentanyl for labour analgesia.

Materials and Methods:
The prospective randomized study was performed on 60 parturients, divided into two groups of 30 subjects each. Group I received 10ml of bupivacaine 0.1% + fentanyl 2µg/ml and Group II received 10ml of ropivacaine 0.1% + fentanyl 2µg/ml by epidural catheter. Pre-anaesthetic evaluation was performed on all the participants and all were administered metoclopramide 0.25mg/kg and ondansetron 0.08-0.1mg/kg intravenously as premedication. The baseline and post anaesthesia systolic, diastolic blood pressure, heart rate, VAS score, degree of motor block, sedation and APGAR score of the baby were recorded. The data were tabulated and statistically analyzed.

Results:
When compared, there was no significant difference in systolic/diastolic blood pressure in two groups except at 360 min where diastolic pressure was low in group II. Significantly higher heart rate at 30 min (P=0.0003), 120 min (0.006), and 300 min (P=0.001) was observed in group I subjects. VAS score was significantly less at 180 min (P=0.019) and 300 min (P=0.019) in group II. Adverse effects such as fetal bradycardia, nausea/vomiting and hypotension observed were clinically insignificance when compared in two groups.

Conclusion:
Bupivacaine and ropivacaine produce an equal degree of analgesia and hemodynamic stability in 0.1% of concentration when added with 2µg/ml fentanyl . However, heart rate was well maintained with lower VAS scores in group II receiving ropivacaine. No significant difference in the side effects between the two groups. Hence, Ropivacaine can be used as a safe alternative to bupivacaine for labour epidural analgesia.
Cystic Fibrosis Point of Personalized Detection (CFPOPD): An Interactive Web Application
Authors: Wolfe Christopher , Pestian Teresa , Gecili Emrah , Su Weiji , Keogh Ruth H , Pestian John P , Seid Michael , Diggle Peter J , Ziady Assem , Clancy John Paul , Grossoehme Daniel H , Szczesniak Rhonda D , Brokamp Cole 
Published: December 2020

Background
Despite steady gains in life expectancy, individuals with cystic fibrosis (CF) lung disease still experience rapid pulmonary decline throughout their clinical course, which can ultimately end in respiratory failure. Point-of-care tools for accurate and timely information regarding the risk of rapid decline is essential for clinical decision support.

Objective
This study aims to translate a novel algorithm for earlier, more accurate prediction of rapid lung function decline in patients with CF into an interactive web-based application that can be integrated within electronic health record systems, via collaborative development with clinicians.

Methods
Longitudinal clinical history, lung function measurements, and time-invariant characteristics were obtained for 30,879 patients with CF who were followed in the US Cystic Fibrosis Foundation Patient Registry (2003-2015). We iteratively developed the application using the R Shiny framework and by conducting a qualitative study with care provider focus groups (N=17).

Results
A clinical conceptual model and 4 themes were identified through coded feedback from application users: (1) ambiguity in rapid decline, (2) clinical utility, (3) clinical significance, and (4) specific suggested revisions. These themes were used to revise our application to the currently released version, available online for exploration. This study has advanced the application’s potential prognostic utility for monitoring individuals with CF lung disease. Further application development will incorporate additional clinical characteristics requested by the users and also a more modular layout that can be useful for care provider and family interactions.

Conclusions
Our framework for creating an interactive and visual analytics platform enables generalized development of applications to synthesize, model, and translate electronic health data, thereby enhancing clinical decision support and improving care and health outcomes for chronic diseases and disorders. A prospective implementation study is necessary to evaluate this tool’s effectiveness regarding increased communication, enhanced shared decision-making, and improved clinical outcomes for patients with CF.
Complemento al simulador de vuelo del helicóptero Bell 206, para las prácticas en la formación de pilotos de la ESAVI
Authors: Medina Echavarria Ricardo Adolfo , Díaz Figueroa John Edisson , Gonzalez Villamil Edgar Eduardo , Perez Oliva Jorge Andres , Rangel Ospino Alex Hernando 
Published: December 2020

En el presente trabajo se buscó realizar el complemento (rediseño) al simulador de vuelo del helicóptero Bell 206, para la práctica de las maniobras de emergencia en la formación de Pilotos Policiales de la ESAVI, el cual consistió en mejorar el material del chasis de la cabina, el tablero de los paneles de mandos, el software de simulación, entre otros. De igual forma de la respectiva prueba de funcionamiento del mismo; además, el simulador de vuelo rediseñado, se mejoró las competencias teórico-prácticas a través de la repetición y aumentó la seguridad operacional de la aeronave cuando ocurren fallas mecánicas o maniobras de alto riesgo. Por otro lado fortaleció los equipos de apoyo educativo con que cuenta la Institución, logrando con ello mejorar el proceso de enseñanza-aprendizaje entre instructores y estudiantes, lo cual tiene como finalidad evitar accidentes aéreos por factores de tipo humano.
Fatores que influenciam o stress dos professores da educação infantil da cidade de Buriticupu/MA
Authors: Coutinho Francisca , Costa Junior Lindemberg 
Published: December 2020

Analisar quais variáveis influenciam o nível stress dos professores da educação da educação infantil foi o objetivo dessa pesquisa. Que se justifica pelos danos que esta doença tem causado a vida dos trabalhadores, em especial aos professores, sendo considerada uma das profissões mais estressantes. Utilizou-se metodologia quantitativa, de caráter descritivo e de corte transversal. Adotou-se o formulário Typerform como ferramenta de coleta de dados. A pesquisa aponta que tanto os professores da rede pública, quanto os professores da rede privada, sentem-se pressionados e estressados. Observou-se que as variáveis, carreira docente, comportamento/indisciplina dos alunos, pressão de tempo e excesso de trabalho, políticas indisciplinares inadequadas e o trabalho burocrático administrativo, são os fatores que mais contribuem para o stress dos professores. Em média, revela-se que as duas maiores fontes do stress desses profissionais são carreira docente e o comportamento/indisciplina dos alunos, sendo que a única variável que as escolas privadas obtiveram a maior média foi o comportamento indisciplina dos alunos. Nesse sentido, observou-se que os docentes de escolas públicas se sentem mais pressionados e estressados que os docentes de escolas privadas.
PALAVRAS – CHAVE: Stress; Gestão escolar; Qualidade de vida.
Estudiantes extranjeros en Santa Fe. El caso de las cohortes brasileñas del Doctorado de Educación de la UCSF
Authors: Gaitan Anabel , Pauli María Gabriela 
Published: December 2020

La propuesta de abordar la migración académica Sur-Sur en educación superior en el presente siglo, nos ha invitado a analizar una experiencia como ha sido la de las cohortes de doctorandos provenientes de Brasil en la Universidad Católica de Santa Fe entre 2006 y 2013, 17 cohortes en total. Se trata de una experiencia particular porque estas cohortes se conformaron exclusivamente con estudiantes extranjeros en su mayoría brasileños, aunque también participaron de la experiencia angoleños, mexicanos y ecuatorianos.
Nos proponemos abordar el caso desde dos perspectivas; por un lado, las decisiones en el marco de la política de la Universidad que hizo posible esta experiencia, y por otro lado, las subjetividades de sus actores, especialmente de los doctorandos.
Ruptured hidden intracranial aneurysm during mechanical thrombectomy: A case report
Authors: Nozaki Toshiki , Noda Masayuki , Ishibashi Toshihiro , Morita Akio 
Published: December 2020

Background:
Acute ischemic stroke (AIS) patients have a higher prevalence of cerebral aneurysm than a healthy reference population. However, it was recently reported that cases of an unknown hidden aneurysm in AIS patients with large-vessel occlusion are rare. We report a rare case of subarachnoid hemorrhage (SAH) during mechanical thrombectomy (MT) using a stent retriever for AIS.

Case Description:
A 46-year-old patient with the right internal carotid artery terminal occlusion presented with the left-sided hemiparesis, hemispatial neglect, and dysarthria and underwent MT. Initial thrombectomy using a stent retriever and reperfusion catheter was unsuccessful. Angiography just before the second attempt showed SAH. Fortunately, we achieved recanalization of the thrombolysis in cerebral infarction 2b and hemostasis by lowering the blood pressure followed by coil embolization of the ruptured aneurysm. Only a few cases of ruptured aneurysms have been reported during MT using a stent retriever. Stent withdrawal is suspected to cause aneurysm rupture in cases with an unknown hidden middle cerebral artery bifurcation aneurysm.

Conclusion:
Preinterventional detection of a hidden aneurysm is difficult. Therefore, surgeons must always consider the possibility of a hidden aneurysm rupture in vessels distal to the occlusion site and make adequate preparations for the prompt treatment of ruptured aneurysms after MT.
TOWARDS CONTENT-MANIFESTATIONAL FEATURES OF THE «FEAR» CONCEPT
Authors: Коновалихина Ксения Викторовна 
Published: December 2020

Статья посвящена манифестациям концепта «страх» в современных лексикографических источниках и текстах художественной литературы. Целью данной работы являются выявление и анализ особенностей лексических средств, номинирующих и описывающих СТРАХ и различные его проявления в современной немецкой лингвокультуре. Выявлены важнейшие концептуальные области исследуемого концепта.
The article analyzes manifestations of the «fear» concept in modern lexicographic sources and in fiction texts. The analysis is aimed at revealing and characterizing the specificity of lexical means which nominate and describe FEAR and its diverse manifestation in modern German linguistic culture. The principal domains of the concept in question are also described.
VERBAL-SEMANTIC LEVEL OF THE LANGUAGE PERSONALITY OF TERESA MEI (BASED ON THE PUBLIC SPEECHES)
Authors: Попова Татьяна Георгиевна , Кокорина Ксения Александровна 
Published: December 2020

Статья представляет собой исследование языковой личности Терезы Мей на вербально-семантическом уровне. Материалом анализа послужили публичные выступления политика в должности премьер-министра Великобритании в период с 2016 по 2019 гг. Авторы статьи делают вывод о том, что основу вербально-семантического уровня языковой личности Терезы Мей составляет нейтральная общеупотребительная лексика. На основании проведенного анализа было выявлено, что вербально-семантический уровень политика характеризуется обилием общеполитической лексики тематики Brexit. В статье также подчеркивается, что в своих политических выступлениях Тереза Мей активно использует военную терминологию, эмоционально-оценочную лексику и лексические повторы.
The article represents a study of the language personality of Theresa May at the verbal-semantic level in the modern political discourse. The material of the study is based on the public speaking material of Theresa May as Prime Minister of Great Britain from 2016 to 2019. It has been established that the basis of the verbal-semantic level of the language personality of Teresa May represents neutral vocabulary. According to the analysis, it was revealed that the verbal-semantic level is characterized by the presence of political vocabulary, which includes political terms, references, lexical units related to the Brexit theme. In addition, the distinctive features are the use of military terminology, emotionally-evaluative vocabulary, means of expressing confidence and lexical repetitions
ASSOCIATIVE EXPERIMENT AS A TOOL TO ANALYZE SCHOOLCHILD’S CONSCIOUSNESS (WITH EVERYSEMANTIC WORDS AS STIMULI)
Authors: Лукьянова Елена Евгеньевна 
Published: December 2020

В статье представлены результаты интерпретации данных, полученных в ходе проведения ассоциативного эксперимента с современными школьниками, изучающими английский язык как иностранный. Цель эксперимента состоит в выявлении специфики формирования когнитивных структур, репрезентируемых словами широкой семантики, в сознании современного школьника. Статистический анализ и интерпретация полученных экспериментальных данных позволяют сделать некоторые предварительные выводы о структуре и содержании этих когнитивных структур.
The article features the findings of the associative experiment held with present-day school children who learn English as their first foreign language. The objective of the experiment lies in unveiling, how cognitive structures, which are represented in the language through everysemantic words, are shaped. The analysis and interpretation of the empirical data helps draw preliminary conclusions about the structure and the contents of the language consciousness of a present-day student.
RESISTENCIA A LA COMPRESIÓN DE LAS RESINAS DENTALES DE NANOPARTICULAS Y SUPRANANOPARTICULAS
Authors: Tejada Grandez Ketty Jhovani , Villalobos Terán Cristian Saúl , Coronel Zubiate Franz Tito 
Published: December 2020

El objetivo fue comparar la resistencia a la compresión de las resinas dentales de nanopartículas y suprananopartículas en Chachapoyas durante el 2018. Material y métodos: La investigación se realizó empleando un enfoque cuantitativo, nivel aplicativo comparativo, observacional, prospectivo, transversal y analítico. El universo muestral lo constituyeron 8 probetas de resina de nanopartículas y 8 de resinas de suprananopartículas. En la recolección de datos usamos como instrumento la máquina universal de ensayos Metrotest. Se aplicó la prueba de Shapiro – Will para contrastar las hipótesis de diferencias, para después aplicar la prueba paramétrica T studet, a un nivel de significancia de p<0.05 y nivel de confianza del 95%. En los resultados: La resina de nanopartículas tiene mayor resistencia a la compresión con una media de 148.47 y la resina de suprananopartículas tuvo una media de 92.09 Mpa. Como conclusión las resinas de nanopartículas tuvieron mayor resistencia a la compresión que las resinas compuestas de suprananopartículas comparadas
KONTEKS EKSTERNAL VIRTUAL DALAM PRAGMATIK SIBER
Authors: Rahardi R. Kunjana 
Published: December 2020

Pragmatik sebagai cabang ilmu bahasa paling muda perlu terus-menerus didukung pertumbuhan dan perkembangannya. Kreativitas dan inovasi dalam menemukan persoalan dan fenomena pragmatik yang layak untuk diteliti dengan perspektif pragmatik perlu terus ditumbuhkan dan dibangkitkan. Penelitian ini bertujuan menggambarkan manifestasi pergeseran satu aspek penting dalam pragmatic siber, yakni konteks virtual. Rumusan masalah penelitian ini adalah: Apakah wujud pergeseran konteks dalam perspektif pragmatik siber? Data penelitian ini adalah elemen dan fungsi konteks yang membentuk konteks virtual itu yang hadir bersama dengan tuturannya. Data dikumpulkan dan disajikan dengan menggunakan metode simak. Metode simak diterapkan dengan melaksanakan penyimakan terhadap data dan sumber data sehingga diperoleh data yang benar-benar siap dianalisis. Sebelum dianalisis, data tersebut ditriangulasi untuk memperoleh validitas data. Triangulasi dilaksanakan dengan menerapkan triangulasi teori, yakni dengan cara mengonfirmasikan data yang telah ditemukan tersebut dengan teori yang ada. Selain itu, data juga ditriangulasi pakar, yakni dengan pakar sejawat yang memang memiliki kompetensi dan kepakaran pragmatik dan konteks pragmatik. Data yang telah terkumpul kemudian diklasifikasi dan ditipikasi sehingga ditemukan manifestasi data yang benar-benar siap dikenakan metode dan teknik analisis. Metode analisis yang diterapkan adalah metode padan, khususnya padan ekstralingual. Hasil penelitian menunjukkan bahwa terdapat wujud-wujud pergeseran pada lima elemen konteks. Kelima wujud pergeseran tersebut disampaikan sebagai berikut: (1) penutur, mitra tutur, dan pelibat tutur lain; (2) setting suasana, waktu, dan tempat; (3) maksud dan tujuan; (4) saluran dan peranti tuturan; (5) genre dan laras tuturan. Penelitian ini bermanfaat bagi pengembangan pragmatik di Indonesia khususnya, sehingga ke depan ilmu pragmatik berkembang jauh lebih baik di negeri ini. Kata Kunci: konteks eksternal konvensional; konteks eksternal virtual; pragmatik siber