bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Neuroendovascular Procedural Volume During the COVID‐19 Pandemic: An International Multicenter Study
Authors: Qureshi Adnan I. , Agunbiade Samiat , Huang Wei , Akhtar Iqra N. , Abraham Michael G. , Akhtar Naveed , Al‐Mufti Fawaz , Aytac Emrah , Balgetir Ferhat , Grigoryan Mikayel , Gomez Camilo R. , Hassan Ameer E. , Jani Vishal , Janjua Nazli A. , Jiao Liqun , Khatri Rakesh , Kirmani Jawad F. , Kobayashi Adam , Kozak Osman , Lee Jun , Lobanova Iryna , Mansour Ossama Yassin , Maud Alberto , Mazighi Mikael , Piotin Michel , Rodriguez Gustavo J. , Siddiq Farhan , Suri M. Fareed K. , Tekle Wondwossen G. 
Published: November 2020

ABSTRACTBACKGROUND AND PURPOSEThe effect of coronavirus disease 2019 (COVID‐19) pandemic on performance of neuroendovascular procedures has not been quantified.METHODSWe performed an audit of performance of neuroendovascular procedures at 18 institutions (seven countries) for two periods; January‐April 2019 and 2020, to identify changes in various core procedures. We divided the region where the hospital was located based on the median value of total number of COVID‐19 cases per 100,00 population‐into high and low prevalent regions.RESULTSBetween 2019 and 2020, there was a reduction in number of cerebral angiograms (30.9% reduction), mechanical thrombectomy (8% reduction), carotid artery stent placement for symptomatic (22.7% reduction) and asymptomatic (43.4% reduction) stenoses, intracranial angioplasty and/or stent placement (45% reduction), and endovascular treatment of unruptured intracranial aneurysms (44.6% reduction) and ruptured (22.9% reduction) and unruptured brain arteriovenous malformations (66.4% reduction). There was an increase in the treatment of ruptured intracranial aneurysms (10% increase) and other neuroendovascular procedures (34.9% increase). There was no relationship between procedural volume change and intuitional location in high or low COVID‐19 prevalent regions. The procedural volume reduction was mainly observed in March‐April 2020.CONCLUSIONSWe provided an international multicenter view of changes in neuroendovascular practices to better understand the gaps in provision of care and identify individual procedures, which are susceptible to change.
Anemia, iron deficiency, and cobalamin deficiency in cats with chronic gastrointestinal disease
Authors: Hunt Adam , Jugan Maria C. 
Published: November 2020

AbstractBackgroundIron deficiency and cobalamin deficiency, as sequelae to chronic gastrointestinal (GI) disease, could result in anemia and increased morbidity in cats with chronic enteropathies.ObjectiveTo evaluate iron deficiency in cats with chronic GI disease and its relationship with hypocobalaminemia, anemia, and disease severity.AnimalsTwenty client‐owned cats with primary GI disease.MethodsProspective, cross‐sectional study. Cats were enrolled at the time of evaluation for chronic GI disease, after exclusion of comorbidities. CBC with reticulocyte indices, iron metabolism (serum iron and ferritin concentrations, total iron binding capacity [TIBC]), serum methylmalonic acid (MMA), cobalamin, and folate concentrations, pancreatic lipase and trypsin‐like immunoreactivity, and disease severity were evaluated.ResultsAnemia (hematocrit <30%), iron deficiency, and cobalamin deficiency were diagnosed in 4/20, 7/20, and 8/20 cats, respectively. Hematocrit (rs = −.45; P < .05) and body condition score (rs = −.60; P < .01) negatively correlated with MMA. Median TIBC was lower in cats with increased vs normal MMA (218 μg/mL; range, 120‐466 μg/mL vs 288 μg/mL; range, 195‐369 μg/mL; P = .02). Hematocrit (rs = .51; P = .02), reticulocyte MCV (rs = .52; P = .02), reticulocyte hemoglobin content (rs = .71; P < .001), and percent transferrin saturation (rs = .79; P < .0001) positively correlated with serum iron concentration.Conclusions and Clinical ImportanceFunctional iron deficiency was common in cats with chronic GI disease. Associations between hypocobalaminemia, iron parameters, and hematologic parameters warrant further investigation on the impact of iron deficiency on chronic GI disease morbidity in cats.
Ages and chemistry of mare basaltic units in the Grimaldi basin on the nearside of the Moon: Implications for the volcanic history of the basin
Authors: Thesniya P. M. , Rajesh V. J. , Flahaut J. 
Published: November 2020

AbstractLunar mare basalts represent flood volcanism between ~4.0 and 1.2 Ga, therefore, providing insights into the thermal and volcanic history of the Moon. The present study investigates the spectral and chemical characteristics as well as ages of the nearside mare basaltic units from the Grimaldi basin, namely Mare Grimaldi and Mare Riccioli, using a wealth of orbital remote sensing data. This study delineated distinct basaltic units of varying albedo, mineralogy, and titanium contents in both Mare Grimaldi and Mare Riccioli. The crater size–frequency distribution technique revealed that at least two phases of basaltic magmatism spanning ~3.5 to 1.5 Ga (Late Imbrian–Eratosthenian) have occurred in the Grimaldi basin. High‐Ti olivine basalts dated at 2.05 Ga are found to be surrounded by the Late Imbrian (~3.47 Ga) low‐ to intermediate‐Ti basalts in Mare Grimaldi. Low‐ to intermediate‐Ti basalts observed in Mare Riccioli date back to two different volcanic events at ~3.5 Ga and ~3.2 billion years, while patches of basalts having remarkably higher titanium content within the Mare Riccioli record the youngest age of ~1.5 Ga. The chemical trend of the pyroxenes from distinct basaltic units also revealed that multiple events of volcanism have occurred in the Grimaldi basin. The high‐Ti basalts in the Mare Grimaldi crystallized from an Fe‐enriched late‐stage magma while the low‐Ti basalts crystallized from an Mg‐ and Ca‐rich initial magma that experienced an ultra‐late stage quenching. The low‐ to intermediate‐Ti basaltic magma erupted in both the units was derived by partial melting of early cumulate materials from the hybrid source region in the post‐overturn upper mantle and made its way to the surface through dikes that propagated by excess pressures accumulated in the diapirs stalled at the base of the crust due to buoyancy trap. The high‐Ti magma erupted in the Mare Grimaldi was generated by a hot plume ascended from deeper clinopyroxene–ilmenite‐rich cumulate layer near the core–mantle boundary. However, the Eratosthenian (~1.5 Ga) intermediate‐Ti volcanic activity in the Mare Riccioli rather sourced from the ilmenite–clinopyroxene cumulate materials that remained in the upper mantle after mantle overturn. The new results suggest that volcanism had not ceased in the Grimaldi basin at 3.27 Ga, rather it was active and fed by different mantle sources until 1.5 Ga for a period spanning ~2 billion years.
Early solar system aqueous activity: K isotope evidence from Allende
Authors: Jiang Yun , Koefoed Piers , Pravdivtseva Olga , Chen Heng , Li Chun‐Hui , Huang Fang , Qin Li‐Ping , Liu Jia , Wang Kun 
Published: November 2020

AbstractThe alkali element K is moderately volatile and fluid mobile; thus, it can be influenced by both primary processes (evaporation and recondensation) in the solar nebula and secondary processes (thermal and aqueous alteration) in the parent body. Since these primary and secondary processes would induce different isotopic fractionations, K isotopes could become a potential tracer to distinguish them. Using recently developed methods with improved precision (0.05‰, 95% confidence interval), we systematically measured the K isotopic compositions and major/trace elemental compositions of chondritic components (18 chondrules, 3 CAIs, 2 matrices, and 5 bulks) in the carbonaceous chondrite fall Allende. Among all the components analyzed in this study, CAIs, which formed initially under high‐temperature conditions in the solar nebula and were dominated by nominally K‐free refractory minerals, have the highest K2O content (average 0.53 wt%) and have K isotope compositions most enriched in heavy isotopes (δ41K: −0.30 to −0.25‰). Such an observation is consistent with previous petrologic studies that show CAIs in Allende have undergone alkali enrichment during metasomatism. In contrast, chondrules contain lower K2O content (0.003–0.17 wt%) and generally lighter K isotope compositions (δ41K: −0.87‰ to −0.24‰). The matrix and bulks are nearly identical in K2O content and K isotope compositions (0.02–0.05 wt%; δ41K: −0.62 to − 0.46‰), which are, as expected, right in the middle of CAIs and chondrules. This strongly indicates that most of the chondritic components of Allende suffered aqueous alteration and their K isotopic compositions are the ramification of Allende parent‐body processing instead of primary nebular signatures. Nevertheless, we propose the small K isotope fractionations observed (< 1‰) among Allende components are likely similar to the overall range of K isotopic fractionation that occurred in nebular environment. Furthermore, the K isotope compositions seen in the components of Allende in this study are consistent with MC‐ICP‐MS analyses of the components in ordinary chondrites, which also show an absence of large (10‰) isotope fractionations. This is not expected as evaporation experiments in nebular conditions suggest there should be large K isotopic fractionations. Nevertheless, possible nebular processes such as chondrules back exchanging with ambient gas when they formed could explain this lack of large K isotopic variation.
Vicariance followed by secondary gene flow in a young gazelle species complex
Authors: Garcia‐Erill Genís , Kjær Michael Munkholm , Albrechtsen Anders , Siegismund Hans Redlef , Heller Rasmus 
Published: November 2020

AbstractGrant's gazelles have recently been proposed to be a species complex comprising three highly divergent mtDNA lineages (Nanger granti, N. notata and N. petersii). The three lineages have nonoverlapping distributions in East Africa, but without any obvious geographical divisions, making them an interesting model for studying the early‐stage evolutionary dynamics of allopatric speciation in detail. Here, we use genomic data obtained by restriction site‐associated (RAD) sequencing of 106 gazelle individuals to shed light on the evolutionary processes underlying Grant's gazelle divergence, to characterize their genetic structure and to assess the presence of gene flow between the main lineages in the species complex. We date the species divergence to 134,000 years ago, which is recent in evolutionary terms. We find population subdivision within N. granti, which coincides with the previously suggested two subspecies, N. g. granti and N. g. robertsii. Moreover, these two lineages seem to have hybridized in Masai Mara. Perhaps more surprisingly given their extreme genetic differentiation, N. granti and N. petersii also show signs of prolonged admixture in Mkomazi, which we identified as a hybrid population most likely founded by allopatric lineages coming into secondary contact. Despite the admixed composition of this population, elevated X chromosomal differentiation suggests that selection may be shaping the outcome of hybridization in this population. Our results therefore provide detailed insights into the processes of allopatric speciation and secondary contact in a recently radiated species complex.
Top‐down controls on nutrient cycling and population dynamics in a model estuarine photoautotroph–heterotroph co‐culture system
Authors: Zheng Qiang , Lin Wenxin , Wang Yu , Xu Dapeng , Liu Yanting , Jiao Nianzhi 
Published: November 2020

AbstractViral lysis and protistan grazing are thought to be the major processes leading to microbial mortality in aquatic environments and thus regulate community diversity and biogeochemical cycling characteristics. Here, we studied nutrient cycling and bacterial responses to cyanophage‐mediated photoautotroph lysis and ciliate predation in a model Synechococcus–heterotroph co‐culture system. Both viral lysis and Euplotes grazing facilitated the transformation of organic carbon from biomass to dissolved organic matter with convention efficiencies of 20%–26%. The accumulation of ammonium after the addition of phages and ciliates suggested the importance of recycled NH4+ occurred in the interactions between Synechococcus growth and heterotrophic bacterial metabolism of photosynthate. The slower efficiency of P mineralization compared to N (primarily ammonium) indicated that P‐containing organic matter was primarily integrated into bacterial biomass rather than being remineralized into inorganic phosphate under C‐rich conditions. In the cyanophage addition treatment, both Fluviicola and Alteromonas exhibited rapid positive responses to Synechococcus lysing, while Marivita exhibited an apparent negative response. Further, the addition of Euplotes altered the incubation system from a Synechococcus‐driven phycosphere to a ciliate‐remodelled zoosphere that primarily constituted grazing‐resistant bacteria and Euplotes symbionts. Top‐down controls increased co‐culture system diversity and resulted in a preference for free‐living lifestyles of dominant populations, which was accompanied by the transfer of matter and energy. Our results indicate top‐down control was particularly important for organic matter redistribution and inorganic nutrient regeneration between photoautotrophs and heterotrophs, and altered bacterial lifestyles. This study consequently sheds light on marine biogeochemical cycling and the interaction networks within these dynamic ecosystems.
CGTase, a novel antimicrobial protein from Bacillus cereus YUPP‐10, suppresses Verticillium dahliae and mediates plant defence responses
Authors: Zhou Jinglong , Feng Zili , Liu Shichao , Wei Feng , Shi Yongqiang , Zhao Lihong , Huang Wanting , Zhou Yi , Feng Hongjie , Zhu Heqin 
Published: November 2020

AbstractVerticillium wilt is a plant vascular disease caused by the soilborne fungus Verticillium dahliae that severely limits cotton production. In a previous study, we screened Bacillus cereus YUPP‐10, an efficient antagonistic bacterium, to uncover mechanisms for controlling verticillium wilt. Here, we report a novel antimicrobial cyclodextrin glycosyltransferase (CGTase) from YUPP‐10. Compared to other CGTases, six different conserved domains were identified, and six mutants were constructed by gene splicing with overlap extension PCR. Functional analysis showed that domain D was important for hydrolysis activity and domains A1 and C were important for inducing disease resistance. Direct effects of recombinant CGTase on V. dahliae included reduced mycelial growth, spore germination, spore production, and microsclerotia germination. In addition, CGTase also elicited cotton's innate defence reactions. Transgenic Arabidopsis thaliana lines that overexpress CGTase showed higher resistance to verticillium wilt. Transgenic CGTase A. thaliana plants grew faster and resisted disease better. CGTase overexpression enabled a burst of reactive oxygen species production and activated pathogenesis‐related gene expression, indicating that the transgenic cotton was better prepared to protect itself from infection. Our work revealed that CGTase could inhibit the growth of V. dahliae, activate innate immunity, and play a major role in the biocontrol of fungal pathogens.
Model adequacy tests for probabilistic models of chromosome‐number evolution
Authors: Rice Anna , Mayrose Itay 
Published: November 2020

Summary

Chromosome number is a central feature of eukaryote genomes. Deciphering patterns of chromosome‐number change along a phylogeny is central to the inference of whole genome duplications and ancestral chromosome numbers. ChromEvol is a probabilistic inference tool that allows the evaluation of several models of chromosome‐number evolution and their fit to the data. However, fitting a model does not necessarily mean that the model describes the empirical data adequately. This vulnerability may lead to incorrect conclusions when model assumptions are not met by real data.

Here, we present a model adequacy test for likelihood models of chromosome‐number evolution. The procedure allows us to determine whether the model can generate data with similar characteristics as those found in the observed ones.

We demonstrate that using inadequate models can lead to inflated errors in several inference tasks. Applying the developed method to 200 angiosperm genera, we find that in many of these, the best‐fitting model provides poor fit to the data. The inadequacy rate increases in large clades or in those in which hybridizations are present.

The developed model adequacy test can help researchers to identify phylogenies whose underlying evolutionary patterns deviate substantially from current modelling assumptions and should guide future methods development.
Large‐scale study validates that regional fungicide applications are major determinants of resistance evolution in the wheat pathogen Zymoseptoria tritici in France
Authors: Garnault Maxime , Duplaix Clémentine , Leroux Pierre , Couleaud Gilles , David Olivier , Walker Anne‐Sophie , Carpentier Florence 
Published: November 2020

Summary

In modern cropping systems, the near‐universal use of plant protection products selects for resistance in pest populations. The emergence and evolution of this adaptive trait threaten treatment efficacy. We identified determinants of fungicide resistance evolution and quantified their effects at a large spatiotemporal scale.

We focused on Zymoseptoria tritici, which causes leaf blotch in wheat. Phenotypes of qualitative or quantitative resistance to various fungicides were monitored annually, from 2004 to 2017, at about 70 sites throughout 22 regions of France (territorial units of 25 000 km2 on average). We modelled changes in resistance frequency with regional anti‐Septoria fungicide use, yield losses due to the disease and the regional area under organic wheat.

The major driver of resistance dynamics was fungicide use at the regional scale. We estimated its effect on the increase in resistance and relative apparent fitness of each resistance phenotype. The predictions of the model replicated the spatiotemporal patterns of resistance observed in field populations (R2 from 0.56 to 0.82).

The evolution of fungicide resistance is mainly determined at the regional scale. This study therefore showed that collective management at the regional scale could effectively complete local actions.
Deployment of wild relatives for genetic improvement in rice (Oryza sativa)
Authors: Gaikwad Kiran B. , Singh Naveen , Kaur Parampreet , Rani Sushma , Babu H Prashanth , Singh Kuldeep 
Published: November 2020

AbstractRice is one of the most important crops in the world. The wild species of rice are expected to have novel beneficial alleles that have been lost from cultivated rice during the process of domestication. Therefore, wild species could be the potential source to induce lost genetic diversity in cultivated rice. Serving as an important reservoir of novel genes/QTLs, wild species, in general, are better adapted to different ecologies and can tolerate many biotic and abiotic stresses. Despite that, only a few wild species are studied and extensive characterization both at the molecular and morphological level is yet to be achieved. Several agronomically important genes/QTLs for improving biotic and abiotic stresses, resistance, productivity and grain quality traits were identified from AA genome donor wild species and were tagged with breeder friendly molecular markers for their transfer to elite genetic backgrounds. The present review provides information on the important wild rice species harbouring genes/QTLs for agriculturally important traits and their successful utilization in rice breeding programmes.
Prevalence and predictors of coronaphobia among frontline hospital and public health nurses
Authors: Labrague Leodoro J. , De Los Santos Janet Alexis A. 
Published: November 2020

AbstractObjectivesTo determine the prevalence as well as the predictors of coronaphobia in frontline hospital and public health nurses.DesignThis study used a cross‐sectional research study involving 736 nurses working in COVID‐19 designated hospitals and health units in Region 8, Philippines. Four structured self‐report scales were used, including the Coronavirus Anxiety Scale, the Brief Resilience Scale, the Perceived Social Support Questionnaire, and the single‐item measure for perceived health.ResultsThe prevalence of coronaphobia was 54.76% (n = 402): 37.04% (n = 130) in hospital nurses and 70.91% (n = 273) in public health nurses. Additionally, nurses' gender (β = 0.148, p < .001), marital status (β = 0.124, p < .001), job status (β = 0.138, p < .001), and personal resilience (β = −0.167, p = .002) were identified as predictors of COVID‐19 anxiety. A small proportion of nurses were willing (19.94%, n = 70) and fully prepared (9.40%, n = 33) to manage and care for coronavirus patients.ConclusionCoronaphobia is prevalent among frontline Filipino nurses, particularly among public health nurses. Interventions to address coronaphobia among frontline nurses in the hospital and community should consider the predictors identified. By increasing personal resilience in nurses through theoretically driven intervention, coronaphobia may be alleviated.
Performance‐Price‐Ratio Utility: Market Equilibrium Analysis and Empirical Calibration Studies
Authors: Xie Yangyang , Xie Lei , Lu Meng , Yan Houmin 
Published: November 2020

In this study, as an alternative to the surplus utility, we propose a performance‐price‐ratio (PPR) utility and specialize the customer choice model with a PPR maximization criterion. With the PPR‐based choice model, we investigate a pricing game between retailers in a competitive market. Through transferring the decision variable from price to performance‐price ratio, the first‐order condition of the game becomes a linear equation system, which enables us to develop a closed‐form equilibrium solution. The solution reveals how product performance and price sensitivity affect equilibrium pricing, market share, and revenue. With the developed theoretical results, we carry out empirical studies with a rich data set obtained from the China TV market. At the individual product level and the brand level, we calibrate the PPR‐based choice model and the widely used surplus‐based model with a Bayesian information criteria‐based stepwise multivariate regression method. The regression results suggest that the PPR‐based model fits both the product‐level and brand‐level data better than the surplus‐based model. Through the stepwise selection of independent variables, we find that the leading features affecting a TV’s performance are 3D TV functionality and its screen size. Moreover, we explore how the market equilibrium evolves with the game decision sequence, market structure, and new product entry.