bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial Family Interventions for Relatives of People Living with Psychotic Disorders in the Arab World: Systematic Review
Authors: Sawafi Aziza Saleh Al , Lovell Karina , Renwick Laoise , Husain Nusrat 
Published: May 2020

Abstract
Aim and objectives: To synthesise the available evidence about culturally-adapted psychosocial family interventions in the Arab world. The review identifies the content and characteristics of these interventions, determines the strategies used to adapt them to the Arab culture successfully, assesses the feasibility and acceptability of the interventions, and evaluates the effectiveness of these interventions for service users and their families. Background: Family interventions in schizophrenia are evidence-based and have been adapted to different cultures to improve their effectiveness and acceptability in different settings. The Arab world has a unique set of sociocultural norms and values that cannot be ignored when developing or implementing such interventions. There is a lack of research on the feasibility of delivering family interventions for schizophrenia in the Arab region. Design: A systematic review Method: Five electronic databases were searched including MEDLINE, CINAHL, Cochrane Library, PsycINFO and EMBASE for articles written in Arabic and English from inception to August 2019. Data were extracted and synthesised narratively. Result: Five studies were retrieved from the search: two randomized control studies, two non-randomized studies and one qualitative study. There is a paucity of evidence about culturally- adapted family interventions in the Arab region. However, the cultural adaptation process was comprehensive, and the implementation was feasible and acceptable. The methodological quality of the included studies was generally poor, so there is a risk of overestimating the effect of the interventions due to lack of rigour and the presence of bias. Conclusion: The present review provided the foundation for future work about family interventions in the Arab world, and confirmed the feasibility of implementing such interventions in the Arab world with minor modifications. Furthermore, the data suggested that any alternative family-oriented intervention for schizophrenia is likely to be better than standard care in improving the outcome for patients and their families.
Alterations in Esophageal MicroRNAs Expression in Primary Esophageal Achalasia by Next-Generation Sequencing
Authors: Gholipour Mahin , Mikaeli Javad , Mowla Seyed Javad , Bakhtiarizadeh Mohammad Reza , Jazi Marie Saghaeian , Javid Naeme , Fazlollahi Narges , Khoshnia Masoud , Behnampour Naser , Moradi Abdolvahab 
Published: May 2020

Abstract
Background: Molecular knowledge regarding the primary esophageal achalasia is essential for early diagnosis and treatment of this neurodegenerative motility disorder. So, there is a need to find the main microRNAs (miRNAs) contributing to the mechanisms of achalasia.Methods: This study was conducted to determine some patterns of deregulated miRNAs in the achalasia. This case-control study was performed on 52 patients with achalasia and 50 non-achalasia controls. The miRNA expression profiling was conducted on the esophageal tissue samples obtained from the patients with achalasia and non-achalasia patients controls using the Next-Generation Sequencing (NGS). Differential expression of miRNAs was analyzed by the edgeR software. The selected dysregulated miRNAs were additionally confirmed using the quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Potential target genes of the downregulated and upregulated miRNAs were also predicted to understand the putative role of the miRNAs in the development of the achalasia. Results: Totally, 15 miRNAs were identified that were significantly altered in the tissues of the patients with achalasia compared to the controls. Among them, three miRNAs including miR-133a-5p, miR-143-3p, and miR-6507-5p were upregulated. Also, six miRNAs including miR-215-5p, miR-216a-5p, miR-216b-5p, miR-217, miR-7641, and miR-194-5p were downregulated significantly. The predicted targets for the dysregulated miRNAs showed significant disease-associated pathways like neuronal cell apoptosis, neuromuscular balance, nerve growth factor signaling, and immune response regulation. Gene expression analysis confirmed significant downregulation of the hsa-miR-217 (p-value = 0.004) in the Lower Esophageal Sphincter (LES) of the patients with achalasia with significant enrichment in the myelination process ontology. The results of this study provide the first integrated miRNA expression profile in the achalasia using the NGS. Our findings introduced 15 candidate miRNAs as achalasia-associated non-coding RNAs and also confirmed the downregulation of the hsa-miR-217 in the achalasia disease. Conclusions: Our results may serve as a basis for more future functional studies to investigate the role of candidate miRNAs in the etiology of achalasia and their application in diagnosis and probably treatment of the disease.
Correlation study between flash dual source CT perfusion imaging and regional lymph node metastasis of non-small cell lung cancer
Authors: Huang Tingting , Sun Hui , Luo Xianli , Zhang Xuemei , Jin Kaiyuan , Wang Feng , Sun Lv , Cheng Nianlan , Wu Shuo , Lou Qin , Li Bangguo 
Published: May 2020

Abstract
Background: To explore the correlation of flash dual source computed tomography perfusion imaging (CTPI) and regional lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate the value of CT perfusion parameters in predicting regional lymph node metastasis of NSCLC. Methods: 120 consecutive patients with NSCLC confirmed by postoperative histopathology were underwent flash dual source CT perfusion imaging in pre-operation. The CT perfusion parameters of NSCLC, such as blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability (PMB) were obtained by the image post-processing. Then microvessel density (MVD), luminal vascular number (LVN), luminal vascular area (LVA) and luminal vascular perimeter (LVP) of NSCLC were counted by immunohistochemistry. These cases were divided into group A (patients with lymph node metastasis, 58 cases) and group B (patients without lymph node metastasis, 62 cases) according to their pathological results. The CT perfusion parameters and the microvessel parameters were contrastively analysed between the two groups. Receiver operating characteristic (ROC) curve was used to assess the diagnostic efficiency of CT perfusion parameters in predicting regional lymph node metastasis of NSCLC in pre-operation. Results: Group A presented signiﬁcantly lower LVA, BF and higher MTT, PMB than Group B (P<0.05), while BV, LVN, LVP and MVD were no significant difference (P>0.05). Correlation analysis showed that BF was correlated with LVA and LVP (P<0.05), while BV, MTT and PMB were not correlated with LVN, LVA and LVP (P>0.05). All the perfusion parameters were not correlated with MVD. According to the ROC curve analysis, when BF<85.16 ml/100 ml/min as a cutoff point to predict regional lymph node metastasis of NSCLC, the sensitivity, speciﬁcity, accuracy, positive predictive value and negative predictive value were 60.8%, 81.7%, 71.5%, 75.6% and 69.5% respectively. Conclusion: Flash dual source CT perfusion imaging can non-invasively indicate the luminal vascular structure of tumor and BF can be used as one of the important indexes in predicting regional lymph node metastasis of NSCLC in pre-operation.
Transcriptome Analysis of Aedes aegypti Aag2 Cells in Response to Dengue Virus-2 Infection
Authors: Li Man-jin , Lan Ce-jie , Gao He-ting , Xing Dan , Gu Zhen-yu , Su Duo , Zhao Tong-yan , Yang Hui-ying , Li Chun-xiao 
Published: May 2020

Abstract
Background
Dengue virus (DENV) is a flavivirus transmitted by mosquitoes that is prevalent in tropical and subtropical countries and has four serotypes (DENV1-4). Aedes aegypti, as the main transmission vector of DENV, exhibits strong infectivity and transmission. With the aim of obtaining a better understanding of the Aedes aegypti-DENV interaction, the transcriptome changes in DENV-2-infected Aag2 cells were studied to describe the immune responses of mosquitoes using the Aedes aegypti Aag2 cell line as a model.
Methods
RNAseq technology was used to sequence the transcripts of the Aedes aegypti Aag2 cell line before and after infection with DENV-2. A bioinformatics analysis was then performed to assess the biological functions of the differentially expressed genes, and the sequencing data were verified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
Results
The transcriptome analysis generated 8,866 unigenes that were found in both groups, 225 unigenes that were only found in the infection group, and 683 unigenes that only existed in the control group. A total of 1199 differentially expressed genes, including 1014 upregulated and 185 downregulated genes, were identified. The bioinformatics analysis showed that the differentially expressed genes were mainly involved in the longevity regulating pathway, circadian rhythm, DNA replication, and peroxisome, purine, pyrimidine, and drug metabolism. The qRT-PCR verification results showed the same trend, which confirmed that the expression of the differentially expressed genes had changed and that the transcriptome sequencing data were reliable.
Conclusions
This study investigated the changes in the transcriptome levels in the DENV-2-infected Aedes aegypti Aag2 cell line, which provides a faster and effective method for discovering genes related to Aedes aegypti pathogen susceptibility. The findings provide basic data and directions for further research on the complex mechanism underlying host-pathogen interactions.
Prevalence and grade of RLS in migraine: a prospective study of 251 migraineurs by synchronous test of c-TTE and c-TCD
Authors: Zhao Qiuxia , Liu Rong , Zhou Jun , Dong Zhizhi , Chen Yue 
Published: May 2020

Abstract
Background
RLS is considered as a risk factor for migraine, but the correlation between the RLS and migraine remains controversial. To investigate the prevalence and Right-to left shunt (RLS) grade of PFO in patients with migraine (including migraine with aura and without) and assess the association between PFO and migraine.
Methods
Synchronous test of contrast transthoracic echocardiography (c-TTE) and contrast transcranial Doppler ultrasonography (c-TCD) was conducted in 251 patients with migraine, including 61 migraine with aura (MA) and 189 migraine without aura (MO) and 275 healthy adults. Among these patients, 25 patients with migraine and 14 healthy adults were evaluated by transesophageal echocardiography (TEE).
Results
(1). The prevalence of permanent RLS, total RLS and large RLS in migraine was significantly higher compared with controls (P = 0.042, < 0.001 and 0.001, respectively). (2). Compared with controls, the positive rate of total RLS and large RLS in MO was increased (P = 0.004 and 0.022 respectively), the positive rate of permanent RLS, total RLS and large RLS in MA was also increased (P < 0.001 for each of the comparisons). The positive rate of permanent RLS and large RLS in MA was significantly higher than in MO (P = 0.004 and 0.011 respectively). (3) The presence of large-size PFO (≥ 2.0 mm) of migraine was higher than that of controls (P = 0.048).
Conclusion
PFO is associated with increased migraine (especially with aura), when the PFO is permanent RLS, large RLS and large-size PFO (≥ 2.0 mm).
Moderate rate of resistance mutations transmitted to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.
Authors: TCHIAKPE EDMOND , Keke Rene K , Vidal Nicole , Ahoussinou Clément , Sekpe Olga , Dagba Hermione G , Gbaguidi Eric , Tonoukouen Conrad , Afangnihoun Aldric , Bachabi Moussa , Gangbo Flore A , Ndiaye Halimatou Diop , Kane Coumba Toure 
Published: May 2020

Abstract
Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed to NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients. Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.
Effects of Region, Epidemic Stage, and Demographic Characteristics on Sleep Quality and Mental Disturbances among Health Care Workers during COVID-19 Outbreak
Authors: Zhang Ruike , Hou Tianya , Kong Xiangyu , Wang Guibin , Wang Hao , Xu Shuyu , Xu Jingzhou , He Jingwen , Xiao Lei , Wang Yajing , Du Jing , Huang Yujia , Su Tong , Tang Yunxiang 
Published: May 2020

Abstract
Objective To investigate the prevalence of sleep quality and mental disturbances of medical staff and identify the effects of region, epidemic stage, and demographic characteristics during the COVID-19 outbreak in China. Method Self-administered questionnaire were sent to health care workers (HCWs) in China from 30 Jan to 2 March, 2020. The Pittsburgh Sleep Quality Index, the Patient Health Questionare-9, the Generalized Anxiety Disorder-7 and the Impact of Event Scale were used to assess sleep quality, depression symptoms, anxiety symptoms and Post-traumatic stress disorder (PTSD) of HCWs, respectively. The influencing factors of psychological and sleep disturbances were identified by univariate analysis and multiple regression. Result The incidence of people getting depression, anxiety or PTSD symptoms were 11.6%,13.3%, 14.3%, respectively. HCWs in Hubei province experienced significantly poorer sleep quality (t=5.034, P<0.001). The predictors of sleep quality among HCWs were COVID-19 stage 2 (β=.135, p=.014) and 3 (β=.184, p=.001), female (β=.141, p=.003) and older age (β=.160, p=.001).Not working in Hubei province (β=-.264, P<0.001) showed to be a protective factor of sleep quality. The risk factors of depression symptoms were not working in Hubei province (OR=4.318, P<0.001), administrative and logistic staff and others (OR=3.538, p=.011), and higher PSQI score (OR=1.282, P<0.001). Having children (under-age: OR=.292, p=.001, grown-up: OR=.293, p=.042) was identified as a protective factor of having depression symptoms. Poor sleep quality showed to be the risk factor of anxiety and PTSD symptoms as well (both p<.001). Furthermore, administrative and logistic staff and others (OR=3.399, p=.006) were found to be the risk factor of PTSD symptoms among HCWs. Conclusion HCWs had poorer sleep quality on stage 2and 3 of the outbreak. HCWs in Hubei had poorer sleep quality but lighter depression condition. gender, age, occupation and status of having children were associated with sleep and mental health. Mental health programs should be considered for HCWs especially those with specific characteristics. Key words COVID-19, Depression, Anxiety, PTSD, Sleep quality, Health care workers
Protocol for a Matched-Pair Cluster Control Trial of ARCHES (Addressing Reproductive Coercion in Health Settings) among Women and Girls Seeking Contraceptive Services from Community-Based Clinics in Nairobi, Kenya
Authors: Uysal Jasmine , Carter Nicole , Johns Nicole , Boyce Sabrina , Liambila Wilson , Undie Chi-Chi , Muketo Esther , Adhiambo Jill , Gray Kate , Wendoh Seri , Silverman Jay 
Published: May 2020

Abstract
Background: Reproductive coercion (RC) and intimate partner violence (IPV) are prevalent forms of gender-based violence (GBV) associated with reduced female control over contraceptive use and subsequent unintended pregnancy. Although the World Health Organization has recommended the identification and support of GBV survivors within health services, few clinic-based models have been shown to reduce IPV or RC, particularly in low or middle-income countries (LMICs). To date, clinic-based GBV interventions have not been shown to reduce RC or unintended pregnancy in LMIC settings. Intervention: ARCHES (Addressing Reproductive Coercion in Health Settings) is a single-session, clinic-based model delivered within routine contraceptive counseling that has been demonstrated to reduce RC in the United States. ARCHES was adapted to the Kenyan context via a participatory process to reduce GBV and unintended pregnancy among women and girls seeking contraceptive services in this setting. Core elements of ARCHES include enhanced contraceptive counseling that addresses RC, opportunity for patient disclosure of RC and IPV (and subsequent warm referral to local services), and provision of a palm-sized educational booklet. Methods: A matched-pair cluster control trial is being conducted to assess whether ARCHES (intervention), as compared to standard-of-care contraceptive counseling (control), reduces RC and IPV, and improves contraceptive outcomes for woman and girls of reproductive age (15 to 49 years) seeking contraceptive services from community-based clinics in Nairobi, Kenya. All six clinics were assigned to intervention-control pairs based on similarities in patient volume and demographics, physical structure and neighborhood context. Survey data will be collected from patients immediately prior to their clinic visit (baseline, T1), immediately after their clinic visit (exit), and at 3- and 6-months post-visit (T2 and T3, respectively). Discussion: This study is the first to assess the efficacy of an adaptation of the ARCHES model to reduce GBV and improve reproductive health outside of the U.S., and one of only a small number of controlled trials to assess reductions in GBV associated with a clinic-based program in an LMIC context. Evidence from this trial will inform health system efforts to reduce GBV, and to enhance female contraceptive control and reproductive health in Kenya and globally. Trial registration: Registered May 2018 - ClinicalTrials.gov NCT03534401. Unique Protocol ID: 170084 This work was supported by the Bill & Melinda Gates Foundation, Grant Number OPP1193177
Strategic Supplementation of Flemingia Silage to Enhance Rumen Fermentation Efficiency, Microbial Protein Synthesis and Methane Mitigation in Beef Cattle
Authors: Viennasay Bounnaxay , Wanapat Metha 
Published: May 2020

Abstract
Background: Good quality protein as an on-farm feed resources has been in great demand to support the productivity of ruminants. A digestion trial using beef cattle crossbreds was conducted to assess the four dietary treatments of Flemingia macrophylla silage (FMS) supplementation at 0, 0.2, 0.4 and 0.6 kg dry matter (DM)/day in a 4 × 4 Latin square design. Feed DM intakes were measured during the 14 days and sample of feeds, feces, urine, as well as rumen fluid, blood were collected during the 7 days while the animals were on metabolism crates.Results: Based on this experiment revealed that strategic supplementation of FMS increased (P < 0.05) nutrients digestibility (organic matter, crude protein, and acid detergent fiber) enhanced rumen total volatile fatty acid production especially propionic acid (C3), C2:C3 ratio while, remarkably promoted the microbial protein synthesis (MPS) by increasing N-balance and retention of purine derivatives.Conclusion: Under this experiment, the results revealed the potential use of FMS as a good-quality feed to improve nutrients digestibility, rumen fermentation, microbial protein synthesis, and to mitigate methane production. FMS supplementation at 0.6 kg DM/day exhibited the best result.
Optimization of Unmanned Aerial Vehicle Augmented Ultra-Dense Networks
Authors: Zamani Alireza , Kämmer Robert , Hu Yulin , Schmeink Anke 
Published: May 2020

Abstract
In this paper, we study the integration of unmanned aerial vehicle small cells (UAV-SC) for the purpose of augmenting or temporarily restoring service to an ultra-dense cellular network. The aim is to minimize the overall power consumption of the network by jointly optimizing the number of UAV-SCs, their placement, associations and the power allocation, subject to user QoS, transmit power and fronthaul capacity constraints. As the resulting optimization problem is non-convex and computationally inefficient to solve, we investigate lower complexity alternatives. By reformulating the original problem, a linear structure can be obtained that is efficiently solved by off-the-shelf solvers. Furthermore, we also propose a meta-heuristic method that is based on particle swarm optimization. The performance of the proposed methods is evaluated via simulation studies and compared to state-of-the-art techniques. The results illustrate that the proposed methods consistently outperform conventional techniques by deploying fewer UAV-SCs and also lowering the transmit powers. Furthermore, considerable power savings were observed particularly for low QoS demands and dense scenarios.
Food consumption frequency and perceived stress and depressive symptoms among female university students in the UAE
Authors: Mohamad Ohoud , Sabbah Haleama Al , Smail Linda , Hermena Ehab W , Ghali Rola Al 
Published: May 2020

Abstract
Background

This study assessed whether perceived stress and depressive symptoms were associated with the frequency of consumption of specific food groups among female university students.
Methods

A cross-sectional study was conducted among female university students using a simple random sampling method. The response rate was 97% yielded a total number of 385 participants. The associations between stress levels and the most/least consumed food groups, and between depressive symptoms levels and the most/least consumed food groups were assessed. The questionnaire included a 12-item self-administered food frequency questionnaire, Cohen’s Perceived Stress Scale, and Beck Depression Inventory-II. The study was approved by the University Ethical Committee before data collection. One-way Analysis of Variance (ANOVA) and the independent-sample t-test were carried out to test the equality of population means across the categories of each independent variable depending on the number of categories of the independent variable.
Results

Overall, this group of female university students fell under the mild mood disturbance category (depressive symptoms) (BDI-II) and had moderate perceived stress (PSS). Perceived stress was associated with more frequent consumption of salad/raw vegetables and cooked vegetables, and less frequent consumption of cake/cookies and meat/sausage products (p < .05). Additionally, depressive symptoms were associated with less frequent consumption of fresh fruits and more consumption of fast food/canned food and soft drinks (p < .05).
Conclusions

The data showed that stress and depression were associated with different dietary preferences consistent with distinctions between stress and depression on human behavior. Specifically, the results revealed associations between soft drinks consumption and higher depressive symptoms, and between frequent consumption of salad/raw vegetables and cooked vegetables and higher perceived stress among this group of female university students.