bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer
Authors: Cavallone Luca , Aguilar-Mahecha Adriana , Lafleur Josiane , Brousse Susie , Aldamry Mohammed , Roseshter Talia , Lan Cathy , Alirezaie Najmeh , Bareke Eric , Majewski Jacek , Ferrario Cristiano , Hassan Saima , Discepola Federico , Seguin Carole , Mihalcioiu Catalin , Marcus Elizabeth A. , Robidoux André , Roy Josée-Anne , Pelmus Manuela , Basik Mark 
Published: September 2020

AbstractResponse to neoadjuvant chemotherapy (NAC) in triple negative breast cancer (TNBC) is highly prognostic and determines whether adjuvant chemotherapy is needed if residual tumor is found at surgery. To evaluate the predictive and prognostic values of circulating tumor DNA (ctDNA) in this setting, we analyzed tumor and serial bloods from 26 TNBC patients collected prior, during, and after NAC. Individual digital droplet PCR assays were developed for 121 variants (average 5/patient) identified from tumor sequencing, enabling ctDNA detection in 96% of patients at baseline. Mutant allele frequency at baseline was associated with clinical characteristics. Levels drastically fell after one cycle of NAC, especially in patients whose tumors would go on to have a pathological complete response (pCR), but then rose significantly before surgery in patients with significant residual tumor at surgery (p = 0.0001). The detection of ctDNA early during treatment and also late at the end of NAC before surgery was strongly predictive of residual tumor at surgery, but its absence was less predictive of pCR, especially when only TP53 variants are considered. ctDNA detection at the end of neoadjuvant chemotherapy indicated significantly worse relapse-free survival (HR = 0.29 (95% CI 0.08–0.98), p = 0.046), and overall survival (HR = 0.27 95% CI 0.075–0.96), p = 0.043). Hence, individualized multi-variant ctDNA testing during and after NAC prior to surgery has prognostic and predictive value in early TNBC patients.
Running performance with emphasis on low temperatures in a Patagonian lizard, Liolaemus lineomaculatus
Authors: Cecchetto N. R. , Medina S. M. , Ibargüengoytía N. R. 
Published: September 2020

AbstractLizard activity and endurance of cold climate is regulated by several factors such as evolutionary potential, acclimatization capacity, physiological tolerance, and locomotion among thermally advantageous microenvironments.Liolaemus lineomaculatus, a lizard inhabiting a wide range of cold environments in Patagonia, provides an excellent model to test interpopulation variability in thermal performance curves (TPCs) and usage of microhabitats. We obtained critical thermal minima and maxima, and performed running trials at eight temperatures using lizards from both a temperate-site (high-altitude) population at 42° S and a cold-site population at 50° S. The availability of environmental temperatures for running performance in open ground and in potential lizard refuges were recorded, and showed that lizards in the temperate site had a greater availability of thermal environments offering temperatures conducive to locomotion. Generalized additive mixed models showed that the two populations displayed TPCs of different shapes in 0.15 m runs at temperatures near their optimal temperature, indicating a difference in thermal sensitivity at high temperatures. However, the rest of the locomotor parameters remained similar betweenLiolaemus lineomaculatusfrom thermal and ecological extremes of their geographic distribution and this may partly explain their ability to endure a cold climate.
Retrospective comparative analysis of choledochoscopic bile duct exploration versus ERCP for bile duct stones
Authors: Al-Habbal Y. , Reid I. , Tiang T. , Houli N. , Lai B. , McQuillan T. , Bird D. , Yong T. 
Published: September 2020

AbstractDebate still exists for the management of choledocholithiasis. The purpose of this study is to quantify the rate of recurrent choledocholithiasis post choledochoscopic bile duct exploration (CBDE) in comparison to ERCP and sphincterotomy, and to demonstrate the feasibility of this approach in a busy metropolitan hospital. Data of patients undergoing CBDE from 2009–2014 at the Northern Hospital, Victoria, Australia, was collected retrospectively. Primary outcomes were bile duct clearance rate and rate of recurrent stones post-clearance. Secondary outcomes measured were post-operative complications, laparoscopic to open conversion rate and operative time. Data of patients undergoing ERCP at the same institution was collected and compared. In total, there were 4,091 cholecystectomy cases performed from 2009–2014, of which 260 (6.3%) of patients had an intraoperative cholangiography (IOC) indicating a common bile duct (CBD) stone. Two hundred and forty-eight patients (95.3%) had a CBDE. The remaining 12 patients (4.6%) had radiological clearance, which were excluded from the study. The overall clearance rate for patients undergoing CBDE was 84% (209/248). The risk of recurrent stones up to 8 years post clearance was 2% (4/209). In the same institution, and between 1998–2012, a total of 1,148 patients underwent ERCP, of which 571 had endoscopic sphincterotomy (ES). Forty-three patients required a repeat ERCP for recurrent CBD stones with a complication rate of 7.5%. Time to recurrence ranged from 6 months to 10 years with a mean of 4.5 years. The rate of recurrence was lower in the CBDE group compared to the patients who had an ERCP (8.9% vs. 2%). CBDE is a feasible and effective method for clearance of CBD stones at the time of laparoscopic cholecystectomy. This approach, although not widely used, reduces the need for ERCP, which has inherent complications. In the longer term, this series showed a significant reduction in the rate of CBD stone recurrence.
Aging and haptic shape discrimination: the effects of variations in size
Authors: Norman J. Farley , Dukes Jessica M. , Palmore Tori N. 
Published: September 2020

AbstractSeventy-two older and younger adults haptically discriminated the solid shape of natural objects (bell peppers, Capsicum annuum). Plastic copies of the original-sized fruits were used as experimental stimuli, as well as copies that were reduced in size to 1/8th and 1/27th of the original object volumes. If haptic object shape is represented in a part-based manner, then haptic shape discrimination performance should be at least partly size invariant, since changes only in scale do not affect an object’s constituent parts. On any given trial, participants sequentially explored two bell pepper replicas and were required to judge whether they possessed the same shape or had different shapes. For some participants, the objects to be discriminated possessed the same size, while for others, the two objects had different sizes. It was found that variations in scale did significantly reduce the participants’ haptic sensitivities to shape. Nevertheless, the discrimination performance obtained for large variations in size was no lower than that obtained for smaller variations in size. The results also demonstrated that increases in age modestly affect haptic shape discrimination performance: the d′ values of the older participants were 15.5% lower than those of the younger participants.
Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
Authors: Ye Shu-Biao , Cheng Yi-Kan , Zhang Lin , Zou Yi-Feng , Chen Ping , Deng Yan-Hong , Huang Yan , Peng Jian-Hong , Wu Xiao-Jian , Lan Ping 
Published: September 2020

AbstractPrior reports have indicated that defective mismatch repair (MMR) has a favorable impact on outcome in colorectal cancer patients treated with surgery, immunotherapy, or adjuvant chemotherapy. However, the impact of MMR status on response to neoadjuvant radiotherapy in rectal cancer is not well understood. Here we report that dMMR was associated with improved disease-free survival (DFS) (P = 0.034) in patients receiving neoadjuvant chemotherapy (NCT). Patients with dMMR tumors who received neoadjuvant chemoradiotherapy (NCRT) achieved significantly worse DFS (P = 0.026) than those treated with NCT. Conversely, NCRT improved DFS (P = 0.043) in patients with pMMR tumors, especially for stage III disease with improved DFS (P = 0.02). The presence of dMMR was associated with better prognosis in rectal cancer patients treated with NCT. NCT benefited patients with dMMR tumors; while NCRT benefited patients with stage III disease and pMMR tumors. Patients stratified by MMR status may provide a more tailored approach to rectal cancer neoadjuvant therapy.
Wireworm (Coleoptera: Elateridae) genomic analysis reveals putative cryptic species, population structure, and adaptation to pest control
Authors: Andrews Kimberly R. , Gerritsen Alida , Rashed Arash , Crowder David W. , Rondon Silvia I. , van Herk Willem G. , Vernon Robert , Wanner Kevin W. , Wilson Cathy M. , New Daniel D. , Fagnan Matthew W. , Hohenlohe Paul A. , Hunter Samuel S. 
Published: September 2020

AbstractThe larvae of click beetles (Coleoptera: Elateridae), known as “wireworms,” are agricultural pests that pose a substantial economic threat worldwide. We produced one of the first wireworm genome assemblies (Limonius californicus), and investigated population structure and phylogenetic relationships of three species (L. californicus, L. infuscatus, L. canus) across the northwest US and southwest Canada using genome-wide markers (RADseq) and genome skimming. We found two species (L. californicus and L. infuscatus) are comprised of multiple genetically distinct groups that diverged in the Pleistocene but have no known distinguishing morphological characters, and therefore could be considered cryptic species complexes. We also found within-species population structure across relatively short geographic distances. Genome scans for selection provided preliminary evidence for signatures of adaptation associated with different pesticide treatments in an agricultural field trial for L. canus. We demonstrate that genomic tools can be a strong asset in developing effective wireworm control strategies.
Significant association between the endothelial lipase gene 584C/T polymorphism and coronary artery disease risk
Authors: Wu Yue-e , Ma Lan , Zhang Hao , Chen Xin-ran , Xu Xin-yi , Hu Ze-ping 
Published: September 2020

Abstract
Several studies have investigated a potential association between the endothelial lipase gene (LIPG) 584C/T polymorphism and susceptibility to coronary artery disease (CAD), but a uniform conclusion is yet to be reached. To better evaluate the true relationship between the LIPG 584C/T polymorphism and the risk of CAD, a meta-analysis of 14 case–control studies with 9731 subjects was performed. Relevant articles published through August 2020 were searched in the CNKI, PubMed, Embase and Web of Science databases. Thirteen articles, including 14 eligible case–control studies with 4025 cases and 5706 controls, were enrolled in the present meta-analysis. The Newcastle–Ottawa Scale (NOS) scores of the case–control studies ranged from 6 to 8. The pooled results indicated that there is a significant association between the LIPG 584C/T polymorphism and CAD in the homozygote comparison model and the allelic comparison model. Subgroup analyses revealed that the LIPG 584C/T mutation significantly decreased the risk of CAD in the subgroups of African, CAD, hospital-based (HB), and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) populations in some genetic models. No publication bias was found in our meta-analysis, which certifies the robustness of the current meta-analysis. Trial sequential analysis (TSA) also confirmed the stability of our results. The results of our meta-analysis indicate that the LIPG 584C/T polymorphism plays a protective role in the incidence of CAD. More high-quality case–control studies on various ethnicities are needed to confirm our results.
Nutzerseitige Adhärenz und Off-Label-Use der
HIV-Prä-Expositionsprophylaxe
Authors: Flössner Christian , Schleenvoigt Benjamin T. , Abendroth Jens , Frese Thomas 
Published: September 2020

Zusammenfassung
Einleitung Die HIV-PrEP (HIV-Prä-Expositionsprophylaxe) ist seit
2017 über deutsche Apotheken in unterschiedlichen Abpackungen
erhältlich. Sie ist entweder als tägliche Einnahme oder als
intermittierende, anlassbezogene Einnahme anwendbar.
Fragestellung Es sollten soziodemografische Basischarakteristika, die
Vorgeschichte hinsichtlich STIs (sexual transmitted infections), der
früheren PEP-Einnahme, das Schema der PrEP-Einnahme, die erfolgte
Vordiagnostik sowie die Beratung zur PrEP-Einnahme und Angaben zur Weitergabe
von PrEP erfasst werden.
Methodik Es wurde eine Querschnittsanalyse in Form eines revidierten,
selbstentwickelten Multiple-Choice-Fragebogens bei 515 Nutzern im Netzwerk
HIV-kompetenter Apotheken durchgeführt.
Ergebnisse Die ausschließlich männlichen Teilnehmer
befinden sich zu 3/4 in der Altersgruppe 20–39 Jahre.
Über 80% der Nutzer wenden die PrEP gemäß
Zulassung an. Etwa 2/3 hatten in früheren Jahren eine PEP
(Post-Expositionsprophylaxe) erhalten. Die gleiche Anzahl hatte in
früheren Jahren mindestens eine STI. Die notwendige Vordiagnostik wurde
überwiegend durchgeführt. Die PrEP wird von 7% an andere
Anwender weitergegeben.
Schlussfolgerung Die Mehrheit (etwa 2/3) der PrEP Nutzer sind
Hochrisiko-Anwender bezogen auf vorherige STIs (sexual transmitted infections)
oder frühere PEP-Anwendung), der überwiegende Anteil nutzt die
PrEP zulassungsgemäß. Der Stellenwert der PrEP wird in der
Zukunft durch einfachere Verordnungsfähigkeit und breitere Anwendung
weiter wachsen.
High practice variation in risk stratification, baseline oncological staging, and follow-up strategies for T1 colorectal cancers in the Netherlands
Authors: Gijsbers Kim , de Graaf Wilmar , Moons Leon M.G. , ter Borg F. ,   (on behalf of the Dutch T1 CRC Working Group)
Published: September 2020

Abstract
Background and study aims Based on pathology, locally resected T1 colorectal cancer (T1-CRC) can be classified as having low- or high-risk for irradicality and/or lymph node metastasis, the latter requiring adjuvant surgery. Reporting and application of pathological high-risk criteria is likely variable, with inherited variation regarding baseline oncological staging, treatment and surveillance.
Methods We assessed practice variation using an online survey among gastroenterologists and surgeons participating in the Dutch T1-CRC Working Group.
Results Of the 130 invited physicians, 53 % participated. Regarding high-risk T1-CRC criteria, lymphangio-invasion is used by 100 %, positive or indeterminable margins by 93 %, poor differentiation by 90 %, tumor-free margin ≤ 1 mm by 78 %, tumor budding by 57 % and submucosal invasion > 1000 µm by 47 %. Fifty-two percent of the respondents do not perform baseline staging in locally resected low-risk T1-CRC. In case of unoperated high-risk patients, we recorded 61 different surveillance strategies in 63 participants, using 19 different combinations of diagnostic tests. Endoscopy is used in all schedules. Mean follow-up time is 36 months for endoscopy, 26 months for rectal MRI and 30 months for abdominal CT (all varying 3–60 months).
Conclusion We found variable use of pathological high-risk T1-CRC criteria, creating risk for misclassification as low-risk T1-CRC. This has serious implications, as most participants will not proceed to oncological staging in low-risk patients and adjuvant surgery nor radiological surveillance is considered. On the other hand, oncological surveillance in patients with a locally resected high-risk T1-CRC who do not wish adjuvant surgery is highly variable emphasizing the need for a uniform surveillance protocol.
Retrovesikales Rezidiv eines Nierenzellkarzinoms 14 Jahre nach laparoskopischer Nephrektomie. Ein Fallbericht
Authors: Drosos Konstantinos , Fischer Karsten , Rieck Guido , Kälble Tilmann 
Published: September 2020

ZusammenfassungMetastasen oder Lokalrezidive eines Nierenzellkarzinoms treten in den meisten Fällen in den ersten fünf Jahren nach Tumornephrektomie oder Nierentumorresektion auf. Dennoch werden immer wieder Spätrezidive oder Metastasen beobachtet. Die häufigsten Lokalisationen sind Lungen und Knochen, aber auch außergewöhnliche Lokalisationen sind möglich. Wir präsentieren den Fall eines 70-jährigen Patienten, bei dem 14 Jahre nach rezidivfreiem Überleben ein solitäres Rezidiv eines klarzelligen Nierenzellkarzinoms retrovesikal diagnostiziert wurde. Bei dem Patienten wurde eine Zystoprostatektomie mit Anlage eines Ileumconduits durchgeführt. Die Resektion erfolgte in sano. Der Verlauf des Patienten bleibt abzuwarten. Wenngleich ein singuläres Spätrezidiv eines Nierenzellkarzinoms retrovesikal selten ist, so gehört das Spätrezidiv zu den spezifischen Charakteristika dieses Tumors. Vor diesem Hintergrund ist für mindestens 15 Jahre eine Tumornachsorge erforderlich. Die kurative chirurgische Resektion ist bei solchen singulären Spätrezidiven Therapie der Wahl.
Risk of appendicitis after endoscopic full-thickness resection of lesions involving the appendiceal orifice: a retrospective analysis
Authors: Schmidbaur Simone , Wannhoff Andreas , Walter Benjamin , Meier Benjamin , Schäfer Claus , Meining Alexander , Caca Karel 
Published: September 2020

Abstract
Background Conventional endoscopic resection of lesions affecting the appendiceal orifice is difficult. Endoscopic full-thickness resection (EFTR) is a novel technique in interventional endoscopy. As EFTR near the appendiceal orifice is associated with a subtotal appendectomy, it remains unclear whether the risk of developing appendicitis is increased. We conducted a retrospective analysis of lesions involving the appendiceal orifice treated by EFTR.
Methods This was a multicenter retrospective analysis of patients (n = 50) treated with EFTR for lesions involving the appendiceal orifice between 2014 and 2019. The objective was to evaluate the occurrence of appendicitis.
Results Acute appendicitis occurred in seven patients (14 %) during follow-up. Conservative treatment was sufficient in four cases, and three patients underwent appendectomy.
Conclusions EFTR of lesions involving the appendiceal orifice may be associated with an imminent risk of developing appendicitis and a consecutive need for appendectomy. Patients should be informed about this specific risk prior to resection. It is unclear why some patients develop appendicitis while the majority remains asymptomatic.
Possible Novel Treatment Modality for Non Ossifying Fibroma Neck of Femur
Authors: Parwaz Mohammed Alam , Chaudhary Tarun , Bansal Suraj 
Published: September 2020

AbstractNonossifying fibromas (NOFs) are benign bone tumors occurring in the second decade of life. Most of the NOFs are diagnosed incidentally on the basis of its presentation on plain radiographs where they typically appear as small, cortical osteolytic lesions with sclerotic margin. They are mostly asymptomatic but can result in pathologic fractures if the lesion involves more than 50% of bone diameter. They are mostly treated with curettage and bone grafting. But in challenging situations where the classical surgery has failed or there is impending fracture of the neck of femur, bone structural support is needed. We are discussing two cases diagnosed as NOFs of intracapsular femoral neck. Both cases underwent curettage of tumor followed by free vascularized fibular graft. Results in both the cases were very gratifying, with complete resolution of symptoms during 1 year of follow-up.
Umbilical Cord Milking in Extremely Preterm Infants: A Randomized Controlled Trial Comparing Cord Milking with Immediate Cord Clamping
Authors: Josephsen Justin B. , Potter Shannon , Armbrecht Eric S. , Al-Hosni Mohamad 
Published: September 2020

Objective This study aimed to assess potential benefits of umbilical cord milking (UCM) when compared with immediate cord clamping (ICC) in extremely preterm infants.
Study Design This is a single-center, randomized controlled trial of infants 240/7 to 276/7 weeks' gestation who received UCM versus ICC. In the experimental group, 18 cm of the umbilical cord was milked three times. The primary aim was to assess the initial hemoglobin and to assess the number of blood transfusions received in the first 28 days after birth. Secondary outcomes were also assessed, including intraventricular hemorrhage (IVH). A priori, neurodevelopmental follow-up was planned at 15 to 18 months corrected gestational age (CGA).
Results Baseline characteristics for 56 enrolled infants were similar in both groups with a mean gestational age of 26.1 ± 1.2 weeks and a mean birth weight of 815 ± 204 g. There were no differences in the mean initial hemoglobin in the UCM group when compared with the ICC group, 13.7 ± 2.0 and 13.8 ± 2.6 g/dL, respectively (p = 0.95), with no differences in median number of blood transfusions after birth between the ICC group and the UCM group, 2 (interquartile range [IQR]: 1–4) versus 2.5 (IQR: 1–5) (p = 0.40). There was also no difference in the rate of severe IVH. At 15 to 18 months CGA, there were no differences in death or disability in the ICC group compared with the UCM group (26 vs. 22%; p = 1.0) and no differences in neurodevelopmental outcomes.
Conclusion In a randomized trial of ICC versus UCM in extremely preterm infants, no differences were seen in initial hemoglobin or number of blood transfusions.
Key Points
The impact of online review helpfulness and word of mouth communication on box office performance predictions
Authors: Lee Sangjae , Choeh Joon Yeon 
Published: September 2020

AbstractWhile electronic word-of-mouth (eWOM) variables, such as volume and valence have been posited in previous studies to consistently affect product sales, there is a lack of studies on the different contexts and outcomes that affect the importance of eWOM variables. In order to fill this gap, this study attempts to use the helpfulness of reviews and reviewers as moderators to predict box office revenue, comparing the prediction performances of business intelligence (BI) methods (random forest, decision trees using boosting, the k-nearest neighbor method, discriminant analysis) using eWOM between high and low review or reviewer helpfulness subsample in the Korean movie market scrawled from the Naver Movies website. The results of applying machine learning methods show that movies with more helpful reviews or those that are reviewed by more helpful reviewers show greater prediction performance, and review and reviewer helpfulness improve the prediction power of eWOM for box office revenue. The prediction performance will improve if the characteristics of eWOM are likely to be combined to contribute to box office revenue to a greater extent.
Dual scanning interferometric technique for measurements of the temperature and concentration dependence of the refractive index of liquids
Authors: Postnikov Alexander 
Published: September 2020

Abstract
A novel laser interferometric technique for measuring the variation of the refractive index with concentration and temperature is presented. The technique is based on the principle of ‘absolute scale’ accomplished with a Michelson interferometer. The linear motion of the scanning mirror allows simple extraction of the optical path change inside the Fabry–Perot interferometer. The measurement of the relative positions of the interference maxima reduces the sensitivity of the system to intensity noise and drift of the laser source. The sensitivity to the changes of the refractive index is of the order of 1 × 10−7 for a 20 mm optical path.