bluuebunny/crossref_metadata_2025_split huggingface dataset:
Location and characteristics of the X-discontinuity beneath SW Morocco and the adjacent shelf area usingP-wave receiver functions
Authors: Rein Theresa , Hannemann Katrin , Thomas Christine , Korn Michael 
Published: August 2020

SUMMARYReceiver function approaches have proven to be valuable for the investigation of crustal and upper mantle discontinuities whose sharp changes in seismic velocities cause wave conversions. While the crustal and mantle transition zone discontinuities are largely understood, the X-discontinuity at 250–350 km depth is still an object of controversial debate. The origin and global distribution of this structure with a velocity jump of 1.5–4.8 % for compressional and shear waves is still unexplained. Although the crustal and mantle transition zone discontinuities beneath SW Morocco and surroundings have been investigated, only a few studies observed the X-discontinuity and place the depth at 260–370 km beneath the region of western Morocco. In order to better locate and characterize the X-discontinuity beneath southwest Morocco, we create P-wave receiver functions using data recorded by the Morocco–Münster array and detect the X-discontinuity at apparent depths of 285–350 km. In the western part of our study region we find apparent depths of ∼ 310–340 km. The eastern part of the study area appears more complex: we locate two velocity jumps at apparent depths of around 285–295 km and 330–350 km in the northeast, and in the southeast we find a discontinuity at apparent depths of 340–350 km. Due to the large depth range and the twofold appearance of the X-discontinuity, we suggest that two different phase transitions cause the X-discontinuity beneath SW Morocco. The velocity contrasts at larger depths likely point to the coesite–stishovite phase transition occurring in deep eclogitic pools. The shallower depths can be explained by the transition from orthoenstatite to high-pressure clinoenstatite which requires the reaction between eclogite and peridotite to form orthopyroxene-rich peridotite. This reaction is likely related to previously proposed small-scale mantle upwellings beneath SW Morocco. Since both phase transitions require eclogite occurrence, the location of the X-discontinuity in this region can be used to indicate the location of recycled oceanic crust.
Prevalence of Flavored e-Cigarette Use Among Subpopulations of Adults in the United States
Authors: Leventhal Adam M , Dai Hongying 
Published: August 2020

Abstract

Background
Evidence of US adult flavored e-cigarette use prevalence stratified by age, smoking status, and purpose for vaping (ie, quitting smoking, to use when or where smoking is not allowed) can inform policies that reduce the tobacco-related cancer burden.

Methods
Current flavored e-cigarette use (use 1 or more nontobacco flavors) prevalence estimates were compared across subpopulation groups using 2-sided statistical significance tests in the July 2018 Current Population Survey Tobacco Use Supplement, a nationally representative cross-sectional adult survey (n = 46 759).

Results
Current flavored e-cigarette use was reported by 1.6% (95% confidence interval [CI] = 1.47% to 1.69%) of all respondents. Among current vapers, the percentage of those who used flavored e-cigarettes was higher for adults aged 18-24 years (89.6%), 25-34 years (86.7%), and 35-44 years (76.0%) than for adults aged 45 years and older (60.4%, Ps &lt; .001); was higher in never smokers (89.8%) than current (72.9%), long-term former (73.9%), and recent former (80.4%) smokers (Ps ≤ .009); was higher in smokers who reportedly did (78.9%) vs did not (71.1%) use e-cigarettes to vape where or when smoking is not allowed (P = .005); and did not differ between smokers who reportedly did (75.0%) vs did not (73.9%) vape to quit smoking (P = .71). Individuals who vaped to quit smoking and currently used flavored e-cigarettes constituted 0.9% (95% CI = 0.82% to 0.99%) of all adults (weighted N = 2 251 000, 95% CI = 2 046 000 to 2 476 000) and 57.2% of current flavored e-cigarette users.

Conclusions
Flavored e-cigarette use prevalence was low among US adults overall but common for current vapers. Flavored e-cigarette use was disproportionately prevalent among never smokers and other subpopulations that might experience harm from vaping.
The discovery of lambda Bootis stars - the Southern Survey II
Authors: Murphy Simon J , Gray Richard O , Corbally Christopher J , Kuehn Charles , Bedding Timothy R , Killam Josiah 
Published: August 2020

ABSTRACT
The λ Boo stars are chemically peculiar A-type stars whose abundance anomalies are associated with the accretion of metal-poor material. We searched for λ Boo stars in the Southern hemisphere in a targeted spectroscopic survey of metal-weak and emission-line stars. Obtaining spectra for 308 stars and classifying them on the MK system, we found or co-discovered 24 new λ Boo stars. We also revised the classifications of 11 known λ Boo stars, one of which turned out to be a chemically normal rapid rotator. We show that stars previously classified in the literature as blue horizontal branch stars or emission-line A stars have a high probability of being λ Boo stars, although this conclusion is based on small-number statistics. Using WISE infrared fluxes, we searched our targets for infrared excesses that might be attributable to protoplanetary or debris discs as the source of the accreted material. Of the 34 λ Boo stars in our sample, 21 at various main-sequence ages have infrared excesses, confirming that not all λ Boo stars are young.
Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
Authors: Sidhu Arshdeep , Grosbart Małgorzata , Sánchez Humberto , Verhagen Bram , van der Zon Nick L L , Ristić Dejan , van Rossum-Fikkert Sarah E , Wyman Claire 
Published: August 2020

Abstract
BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sample a broad range of conformational space. We expect that the resulting dynamic arrangements of BRCA2 domains are a functionally important aspect of its role in homologous recombination DNA repair. To determine the architectural organization and the associated conformational landscape of BRCA2, we used scanning force microscopy based single molecule analyses to map the flexible regions of the protein and characterize which regions influence oligomerization. We show that the N- and the C-terminal regions are the main flexible regions. Both of these regions also influence BRCA2 oligomerization and interaction with RAD51. In the central Brc repeat region, Brc 1–4 and Brc 5–8 contribute synergistically to BRCA2 interaction with RAD51. We also analysed several single amino acid changes that are potentially clinically relevant and found one, the variant of F1524V, which disrupts key interactions and alters the conformational landscape of the protein. We describe the overall conformation spectrum of BRCA2, which suggests that dynamic structural transitions are key features of its biological function, maintaining genomic stability.
TIF-Seq2 disentangles overlapping isoforms in complex human transcriptomes
Authors: Wang Jingwen , Li Bingnan , Marques Sueli , Steinmetz Lars M , Wei Wu , Pelechano Vicent 
Published: August 2020

Abstract
Eukaryotic transcriptomes are complex, involving thousands of overlapping transcripts. The interleaved nature of the transcriptomes limits our ability to identify regulatory regions, and in some cases can lead to misinterpretation of gene expression. To improve the understanding of the overlapping transcriptomes, we have developed an optimized method, TIF-Seq2, able to sequence simultaneously the 5′ and 3′ ends of individual RNA molecules at single-nucleotide resolution. We investigated the transcriptome of a well characterized human cell line (K562) and identified thousands of unannotated transcript isoforms. By focusing on transcripts which are challenging to be investigated with RNA-Seq, we accurately defined boundaries of lowly expressed unannotated and read-through transcripts putatively encoding fusion genes. We validated our results by targeted long-read sequencing and standard RNA-Seq for chronic myeloid leukaemia patient samples. Taking the advantage of TIF-Seq2, we explored transcription regulation among overlapping units and investigated their crosstalk. We show that most overlapping upstream transcripts use poly(A) sites within the first 2 kb of the downstream transcription units. Our work shows that, by paring the 5′ and 3′ end of each RNA, TIF-Seq2 can improve the annotation of complex genomes, facilitate accurate assignment of promoters to genes and easily identify transcriptionally fused genes.
Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Chaves Carolina , Bittencourt Paulo Cesar T , Pelegrini Andreia 
Published: August 2020

Abstract

Objective
To determine the benefit of a tetrahydrocannabinol (THC)-rich cannabis oil on symptoms and quality of life of fibromyalgia patients.

Methods
A double-blind, randomized, placebo-controlled clinical trial was conducted for eight weeks to determine the benefit of a THC-rich cannabis oil (24.44 mg/mL of THC and 0.51 mg/mL of cannabidiol [CBD]) on symptoms and quality of life of 17 women with fibromyalgia, residents of a neighborhood with a low socioeconomic profile and a high incidence of violence in the city of Florianopolis, Brazil. The initial dose was one drop (∼1.22 mg of THC and 0.02 mg of CBD) a day with subsequent increases according to symptoms. The Fibromyalgia Impact Questionnaire (FIQ) was applied at pre- and postintervention moments and in five visits over eight weeks.

Results
There were no significant differences on baseline FIQ score between groups. However, after the intervention, the cannabis group presented a significant decrease in FIQ score in comparison with the placebo group (P = 0.005) and in comparison with cannabis group baseline score. (P &lt; 0.001). Analyzing isolated items on the FIQ, the cannabis group presented significant improvement on the “feel good,” “pain,” “do work,” and “fatigue” scores. The placebo group presented significant improvement on the “depression” score after intervention. There were no intolerable adverse effects.

Conclusions
Phytocannabinoids can be a low-cost and well-tolerated therapy to reduce symptoms and increase the quality of life of patients with fibromyalgia. Future studies are still needed to assess long-term benefits, and studies with different varieties of cannabinoids associated with a washout period must be done to enhance our knowledge of cannabis action in this health condition.
Religions in action: the role of interreligious dialogue in the COVID-19 pandemic
Authors: Corpuz Jeff Clyde G 
Published: August 2020

Abstract
Recent correspondence letters to the editor of this journal pointed on the praxis of faith in the context of COVID-19 pandemic. The #ChurchinAction presents the role of religious interventions in times of COVID-19. However, a question is raised: how to promote interreligious dialogue in the context of COVID-19 pandemic? To address this question, people of different faiths/religions should come together in promoting the life and dignity of the human person, a sense of community, and participation, respecting the rights and responsibilities of each person, helping the poor and vulnerable sectors of the society, respecting the dignity of work and the rights of the workers, solidarity and caring for the whole creation. In this perspective, interreligious dialogue highlighted the importance of world religions in order to provide a spiritual intervention. The dialogue of life, dialogue of action, dialogue of theological exchange, and dialogue of religious experiences promote interreligious dialogue in the context of COVID-19 pandemic.
Defining heart disease risk for death in COVID-19 infection
Authors: Li J , Guo T , Dong D , Zhang X , Chen X , Feng Y , Wei B , Zhang W , Zhao M , Wan J 
Published: August 2020

SummaryBackgroundCardiovascular disease (CVD) was in common in coronavirus disease 2019 (COVID-19) patients and associated with unfavorable outcomes. We aimed to compare the clinical observations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with or without CVD.MethodsPatients with laboratory-confirmed SARS-CoV-2 infection were clinically evaluated at Wuhan Seventh People’s Hospital, Wuhan, China, from 23 January to 14 March 2020. Demographic data, laboratory findings, comorbidities, treatments and outcomes were collected and analyzed in COVID-19 patients with and without CVD.ResultsAmong 596 patients with COVID-19, 215 (36.1%) of them with CVD. Compared with patients without CVD, these patients were significantly older (66 vs. 52 years) and had higher proportion of men (52.5% vs. 43.8%). Complications in the course of disease were more common in patients with CVD, included acute respiratory distress syndrome (22.8% vs. 8.1%), malignant arrhythmias (3.7% vs. 1.0%) including ventricular tachycardia/ventricular fibrillation, acute coagulopathy(7.9% vs. 1.8%) and acute kidney injury (11.6% vs. 3.4%). The rate of glucocorticoid therapy (36.7% vs. 25.5%), Vitamin C (23.3% vs. 11.8%), mechanical ventilation (21.9% vs. 7.6%), intensive care unit admission (12.6% vs. 3.7%) and mortality (16.7% vs. 4.7%) were higher in patients with CVD (both P &lt; 0.05). The multivariable Cox regression models showed that older age (≥65 years old) (HR 3.165, 95% CI 1.722–5.817) and patients with CVD (HR 2.166, 95% CI 1.189–3.948) were independent risk factors for death.ConclusionsCVD are independent risk factors for COVID-19 patients. COVID-19 patients with CVD were more severe and had higher mortality rate, early intervention and vigilance should be taken.
The Benefits of Tying Yourself in Knots: Unraveling the Learning Mechanisms of Guided Discovery Learning in an Open Surgical Skills Course
Authors: Aagesen Andreas H. , Jensen Rune D. , Cheung Jeffrey J.H. , Christensen John B. , Konge Lars , Brydges Ryan , Thinggaard Ebbe , Kulasegaram Kulamakan M. 
Published: August 2020

Purpose
Teaching technical skills through the use of guided discovery learning (GDL) is an ongoing topic of research. In this approach, learners practice and struggle before receiving formal instruction. This has shown promise in other domains of learning, yet in the realm of procedural skills, clarity is still needed. This study seeks to address these gaps by investigating efficacy and mechanisms relating to application for a GDL approach in teaching basic surgical skills.

Method
In 2018, young surgical trainees (N = 16) undertook a 6-week open surgical course applying the principles of GDL, each lesson beginning with a discovery phase before subsequent instruction and practice. A concurrent triangulation mixed-methods approach was used with direct observation and collection of semistructured interviews using a framework designed from productive failure literature. At the end of the course, all participants took a conceptual knowledge test and a performance-based skills test. Performance on the skills test was rated using global ratings and checklists.

Results
The GDL cohort outperformed the historical cohort on the written exam (F [1,65] = 4.96, P = .029, d = .62), as well as on the summative suturing test (F [1,65] = 6.23, P = .015, d = .68). Furthermore, 3 main themes that highlight the mechanisms and mediators of efficient GDL were: (1) building conceptual knowledge, (2) motivating self-regulated learning, and (3) the type of skill and psychological safety.

Conclusions
GDL can be an efficient approach to teaching procedural skills. Implications for future research and curricular design are discussed.
Anxiety Sensitivity Moderates the Association Between Peritraumatic Distress and Bereavement Outcomes Among Sudden Loss Survivors
Authors: Williams Joah L. , Hardt Madeleine M. , Henschel Aisling V. , Jobe-Shields Lisa 
Published: August 2020

Abstract
Peritraumatic distress and anxiety sensitivity are associated with complications in bereavement, including posttraumatic stress and prolonged grief reactions. The extent to which these factors interact to contribute to bereavement-related distress, however, remains unclear. This study investigates whether anxiety sensitivity moderates the association between peritraumatic reactions and posttraumatic stress and prolonged grief symptoms in a sample of young adults with a history of bereavement due to sudden, unexpected deaths. Participants were 606 undergraduate students recruited from two US universities. Results suggest that peritraumatic emotional and physical distress and anxiety sensitivity are all independently associated with both posttraumatic stress and prolonged grief reactions. Furthermore, the association between peritraumatic distress and prolonged grief, but not posttraumatic stress, is moderated by anxiety sensitivity. These findings point to several potentially important, clinically modifiable factors associated with a variety of bereavement-related mental health problems among a vulnerable group of grievers.
Conjunctival Carcinomas Arising in the Anophthalmic Socket
Authors: Bonavolontà Paola , Fossataro Federica , Tranfa Fausto , Iuliano Adriana , Bonavolontà Giulio , Califano Luigi 
Published: August 2020

Purpose:
The aim of this study was to report management and outcomes of patients in which conjunctival carcinomas arose in the anophthalmic socket.

Methods:
The authors retrospectively analyzed the data of patients which presented the anophthalmic socket after surgery. The clinical records of 4 patients with histological diagnosis of conjunctival carcinoma in the anophthalmic socket, referred to our Department, between January 2014 and December 2019 was collected.

Results:
The study included 4 men (median age 58 years). A previous enucleation surgery had been performed in all patients due to previous ocular trauma for three patients (Case 1, 3, and 4) and due to a retinoblastoma for 1 patient (Case 2). All patients underwent surgical excision of the lesion and only 1 patient (case 3) underwent orbital exenteration due to the high-grade of the cancer. The most common tumor was the squamous cell carcinoma (2 cases) followed by 1 case of high-grade mucoepidermoid carcinoma and 1 case of carcinoma in situ. Systemic work-up was performed for all the patients. Conjunctival TNM, according to the American Joint Committee on Cancer TNM staging system was used to stage the lesions. The median follow-up time was 15 months.

Conclusion:
Considering the severity and rarity of these tumors, a careful ophthalmological examination of the cavity and a correct revision of the prosthesis should be mandatory in order to ensure the elimination of any macro and microscopic irregularities that can then in the long-term cause chronic inflammation of the tissues and consequently promote the growth of carcinomas.
The Prevalence of Blood-Borne Pathogens in Maxillofacial Trauma Patients
Authors: Gebran Selim G. , Wasicek Philip J. , Wu Yinglun , Lopez Joseph , Ngaage Ledibabari M. , Rasko Yvonne M. , Nam Arthur J. , Grant Michael P. , Steinberg Jordan P. , Liang Fan 
Published: August 2020

Background:
Blood-borne pathogen infections (BPIs), caused by the human immunodeficiency virus, hepatitis C and hepatitis B viruses pose an occupational hazard to healthcare workers. Facial trauma reconstruction surgeons may be at elevated risk because of routine use of sharps, and a higher than average incidence of BPIs in the trauma patient population.

Methods:
The authors retrospectively reviewed health records of patients admitted to a level 1 trauma center with a facial fracture between January 2010 and December 2015. Patient demographics, medical history, mechanism of injury, type of fracture, and procedures performed were documented. The authors detemined the frequency of human immunodeficiency virus, hepatitis B, and hepatitis C diagnosis and utilized univariable/multivariable analyses to identify risk factors associated with infection in this population.

Results:
In total, 4608 consecutive patients were included. Infections were found in 4.8% (n = 219) of patients (human immunodeficiency virus 1.6%, hepatitis C 3.3%, hepatitis B 0.8%). 76.3% of BPI patients in this cohort were identified by medical history, while 23.7% were diagnosed by serology following initiation of care. 39.0% of all patients received surgical treatment during initial hospitalization, of whom 4.3% had a diagnosed BPI. History of intravenous drug use (odds ratio [OR] 6.79, P < 0.001), assault-related injury (OR 1.61, P = 0.003), positive toxicology screen (OR 1.56, P = 0.004), and male gender (OR 1.53, P = 0.037) were significantly associated with a BPI diagnosis.

Conclusion:
Patients presenting with facial fractures commonly harbor a BPI. The benefit of early diagnosis and risk to surgical staff may justify routine screening for BPI in high risk facial trauma patients (male, assault-related injury, and history of intravenous drug use).
Presurgical Orthopedic Intervention Prior to Cleft Lip and Palate Repair: Nasoalveolar Molding Versus Passive Molding Appliance Therapy
Authors: Gibson Ella , Pfeifauf Kristin D. , Skolnick Gary B. , Kim Andrew , Naidoo Sybill D. , Snyder-Warwick Alison , Huebener Donald V. , Patel Kamlesh B. 
Published: August 2020

Background:
Nasoalveolar molding (NAM) is a widely used presurgical orthopedic device, despite disputes over its effectiveness. This study compares the outcomes after cleft lip and nose repair in patients who received NAM versus those who underwent passive alveolar molding with lip taping.

Methods:
A retrospective review of patients with complete unilateral cleft lip and palate who received either NAM (n = 16) or passive molding (n = 10) treatments was conducted. Alveolar gap width was measured on maxillary casts until time of palatoplasty. Nasolabial symmetry was assessed by examining anthropometric ratios on post-operative three-dimensional photographs. Burden of care was evaluated by analyzing the number of patient appointments attended, treatment costs, and caregiver satisfaction surveys.

Results:
No statistically significant difference existed in alveolar gap at time of initial appointment or palatoplasty, however the gap was smaller in the NAM cohort at time of lip and nose repair. No statistically significant difference existed in postsurgical heminasal width, nostril width, nostril height, labial height or nasal ala projection asymmetry between the NAM and the passive molding cohort. Patients in the NAM group attended more dental appointments and incurred higher treatment costs compared to the passive molding group. Caregivers reported high satisfaction with treatment outcomes in both cohorts.

Conclusions:
There were no differences between NAM and passive molding regarding postsurgical nasolabial appearance and patient satisfaction. Both treatments narrow the alveolar gap. However, NAM places a higher burden of care on families.