bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid eruption of silicic magmas from the Paraná magmatic province (Brazil) did not trigger the Valanginian event
Authors: Rocha Brenda C. , Davies Joshua H.F.L. , Janasi Valdecir A. , Schaltegger Urs , Nardy Antônio J.R. , Greber Nicolas D. , Lucchetti Ana Carolina F. , Polo Liza A. 
Published: July 2020

Abstract
The Valanginian Stage is marked by a period of global positive δ13C carbon cycle perturbation and biotic crises, which are collectively referred to as the Valanginian event (VE). Many attempts have been made to link the Paraná-Etendeka large igneous province volcanism with the VE. However, currently there is no conclusive proof to support this hypothesis, since the timing and duration of the volcanic activity are not known with sufficient precision. In this study, we significantly revise the time scales of magmatism and environmental impact of the Paraná magmatic province (PMP) in Brazil with new high-precision zircon U-Pb ages from the low-Ti Palmas and high-Ti Chapecó sequences. Our data demonstrate that significant volumes of low-Ti silicic rocks from the PMP erupted rapidly at ca. 133.6 Ma within 0.12 ± 0.11 k.y. The age of the high-Ti Chapecó sequence from central PMP is constrained at ca. 132.9 Ma and thus extends the duration of magmatic activity by ∼700 k.y. Our new ages are systematically younger than previous ages and postdate the major positive carbon isotope excursion, indicating that PMP silicic magmatism did not trigger the VE but could have contributed to extending its duration. Within the framework of the stratigraphic column of the PMP, the earliest low-Ti basalts could have been responsible for the VE if they are at least 0.5 m.y. older than the low-Ti silicic rocks dated herein.
Indo-Atlantic plate accelerations around the Cretaceous-Paleogene boundary: A time-scale error, not a plume-push signal
Authors: Pérez-Díaz L. , Eagles G. , Sigloch K. 
Published: July 2020

AbstractIt has been suggested that plume arrival at the base of the lithosphere introduces a push force that overwhelms the balance of torques driving plate circuits, leading to plate-tectonic reorganizations. Among the most compelling evidence in support of a “plume-push” mechanism is the apparent coincidence between eruption of the Deccan flood basalts around 67–64 Ma and a short-lived increase in Indian (and decrease in African) plate speed. Using existing and newly calculated high-resolution plate-motion models, we show that plate divergence rates briefly increased throughout the Indo-Atlantic circuit, contrary to the expected effects of plume-push. We propose that this circuit-wide spike in divergence rates is best explained as the artifact of a magnetic reversal time-scale error around the much studied Cretaceous-Tertiary boundary, and that the period spanning chrons C29–C28 lasted 70% longer than currently assumed. Corrected for this error, the residual long-term patterns of Indo-Atlantic plate motions and accompanying plate-tectonic reorganization are explicable in terms of maturation of the circuit’s spreading ridges, without invoking a significant plume-push force.
Incidence and risk factors for falls among community-dwelling elderly subjects on a 1-year follow-up: a prospective cohort study from Ernakulam, Kerala, India
Authors: Sasidharan Divyamol K , Vijayakumar Priya , Raj Manu , Soman Sumi , Antony Libin , Sudhakar Abish , Kabali Conrad 
Published: July 2020

ObjectivesThere is limited knowledge regarding epidemiology and risk of falls among the elderly living in low-income and middle-income countries. In this situation, the current study aims to report the incidence of falls and associated risk factors among free living elderly population from Kerala, India.DesignProspective cohort study with stratified random cluster sampling.SettingThe study location was Ernakulam, Kerala, India, and we collected information via house visits using a questionnaire. During the research, the subjects were followed up prospectively for 1 year by phone at intervals of 3 months and missing subjects were contacted by house visits.ParticipantsCommunity-dwelling elderly above 65 years of age.ResultsWe recruited a total of 1000 participants out of which a total of 201 (20.1%) subjects reported a fall during the follow-up. The incidence rate of falls was 31 (95% CI 27.7 to 34.6) per 100 person-years. Female sex (OR 1.48, 95% CI 1.05 to 2.10, p=0.027), movement disorders including Parkinsonism (OR 2.26, 95% CI 1.00 to 5.05, p=0.048), arthritis (OR 1.48, 95% CI 1.05 to 2.09, p=0.026), dependence in basic activities of daily living (OR, 3.49, 95% CI 2.00 to 6.09, p<0.001), not using antihypertensive medications (OR, 1.53, 95% CI 1.10 to 2.13, p=0.012), living alone during daytime (OR 3.27, 95% CI 1.59 to 6.71, p=0.001) and a history of falls in the previous year (OR, 2.25, 95% CI 1.60 to 3.15, p<0.001) predicted a fall in the following year.ConclusionsOne in five community-dwelling senior citizen fall annually and one in four who fall are prone to fall again in the following year. Interventions targeting falls among the elderly need to focus on modifiable risk factors such as living alone during daytime, movement disorders, arthritis and dependence on basic activities of daily living.
‘Transgender Education for Affirmative and Competent HIV and Healthcare (TEACHH)’: protocol of community-based intervention development and a non-randomised multisite pilot study with pre–post test design in Canada
Authors: Lacombe-Duncan Ashley , Logie Carmen H , Persad Yasmeen , Leblanc Gabrielle , Nation Kelendria , Kia Hannah , Scheim Ayden I , Lyons Tara , Loutfy Mona 
Published: July 2020

IntroductionEducational workshops are a promising strategy to increase healthcare providers’ ability to provide gender-affirming care for transgender (trans) people. This strategy may also reduce healthcare providers’ stigma towards trans people and people living with HIV. There is less evidence, however, of educational workshops that address HIV prevention and care among trans women. This protocol details development and pilot testing of the Transgender Education for Affirmative and Competent HIV and Healthcare intervention that aims to increase gender-affirming HIV care knowledge and perceived competency, and to reduce negative attitudes/biases, among providers.Methods and analysisThis community-based research (CBR) project involves intervention development and implementation of a non-randomised multisite pilot study with pre–post test design. First, we conducted a qualitative formative phase involving focus groups with 30 trans women and individual interviews with 12 providers to understand HIV care access barriers for trans women and elicit feedback on a proposed workshop. Second, we will pilot test the intervention with 90–150 providers (n=30–50×3 in-person settings). For pilot studies, primary outcomes include feasibility (eg, completion rate) and acceptability (eg, workshop satisfaction). Secondary preintervention and postintervention outcomes, assessed directly preceding and following the workshop, include perceived competency, attitudes/biases towards trans women with HIV, and knowledge needed to provide gender-affirming HIV care. Primary outcomes will be summarised as frequencies and proportions (categorical variables). We will conduct paired-sample t-tests to explore the direction of preintervention and postintervention differences for secondary outcomes.Ethics and disseminationThis study has been approved by the University of Toronto HIV Research Ethics Board (Protocol Number: 00036238). Study findings will be disseminated through community forums with trans women and service providers; manuscripts submitted to peer reviewed journals; and conferences. Findings will inform a larger CBR research agenda to remove barriers to engagement in HIV prevention/care among trans women across Canada.Trial registration numberNCT04096053; Pre-results.
Open-label, multicentre, single-arm trial of monthly injections of depot buprenorphine in people with opioid dependence: protocol for the CoLAB study
Authors: Larance Briony , Byrne Marianne , Lintzeris Nicholas , Nielsen Suzanne , Grebely Jason , Degenhardt Louisa , Shahbazi Jeyran , Shanahan Marian , Lancaster Kari , Dore Gregory , Ali Robert , Farrell Michael 
Published: July 2020

IntroductionOpioid agonist treatment is effective for opioid dependence and newer extended-release buprenorphine (BUP-XR) injections represent a significant development. The Community Long-Acting Buprenorphine (CoLAB) study aims to evaluate client outcomes among people with opioid dependence receiving 48 weeks of BUP-XR treatment, and examines the implementation of BUP-XR in diverse community healthcare settings in Australia.Methods and analysisThe CoLAB study is a prospective single-arm, multicentre, open-label trial of monthly BUP-XR injections in people with opioid dependence. Participants are being recruited from a network of general practitioner and specialist drug treatment services located in the states of New South Wales, Victoria and South Australia in Australia. Following a minimum 7 days on 8–32 mg of sublingual buprenorphine (±naloxone), participants will receive monthly subcutaneous BUP-XR injections administered by a healthcare practitioner at intervals of 28 days (−2/+14 days). The primary endpoint is participant retention in treatment at 48 weeks after treatment initiation. Secondary endpoints will evaluate dosing schedule variations, craving, withdrawal, substance use, health and well-being, and client-reported treatment experience. Qualitative and costing substudies will examine implementation barriers and facilitators at the client and provider level.Ethics and disseminationThe study has received ethics approval from the St Vincent’s Hospital Sydney Human Research Ethics Committee (Ref. HREC/18/SVH/221). The findings will be disseminated via publication in peer-reviewed journals, presentations at national and international scientific conferences, and in relevant community organisation publications and forums.Trial registration numberNCT03809143Protocol identifierCoLAB1801, V.4.0 dated 01 August 2019
Organisational culture and the integrated chronic diseases management model implementation fidelity in South Africa: a cross-sectional study
Authors: Lebina Limakatso , Kawonga Mary , Alaba Olufunke , Khamisa Natasha , Otwombe Kennedy , Oni Tolu 
Published: July 2020

ObjectiveTo assess whether organisational culture influences the fidelity of implementation of the Integrated Chronic Disease Management (ICDM) model at primary healthcare (PHC) clinics.DesignA cross-sectional study.SettingThe ICDM model was introduced in South African clinics to strengthen delivery of care and improve clinical outcomes for patients with chronic conditions, but the determinants of its implementation have not been assessed.ParticipantsThe abbreviated Denison organisational culture (DOC) survey tool was administered to 90 staff members to assess three cultural traits: involvement, consistency and adaptability of six PHC clinics in Dr. Kenneth Kaunda and West Rand (WR) health districts.Primary and secondary outcome measuresEach cultural trait has three indices with five items, giving a total of 45 items. The items were scored on a Likert scale ranging from one (strongly disagree) to five (strongly agree), and mean scores were calculated for each item, cultural traits and indices. Descriptive statistics were used to describe participants and clinics, and Pearson correlation coefficient to asses association between fidelity and culture.ResultsParticipants’ mean age was 38.8 (SD=10.35) years, and 54.4% (49/90) were nurses. The overall mean score for the DOC was 3.63 (SD=0.58). The involvement (team orientation, empowerment and capability development) cultural trait had the highest (3.71; SD=0.72) mean score, followed by adaptability (external focus) (3.62; SD=0.56) and consistency (3.56; SD=0.63). There were no statistically significant differences in cultural scores between PHC clinics. However, culture scores for all three traits were significantly higher in WR (involvement 3.39 vs 3.84, p=0.011; adaptability 3.40 vs 3.73, p=0.007; consistency 3.34 vs 3.68, p=0.034).ConclusionLeadership intervention is required to purposefully enhance adaptability and consistency cultural traits of clinics to enhance the ICDM model’s principles of coordinated, integrated, patient-centred care.
Prevalence and correlates of overweight and obesity among adolescents in northeastern China: a cross-sectional study
Authors: Duan Ruixin , Kou Changgui , Jie Jing , Bai Wei , Lan Xiaoxin , Li Yuanyuan , Yu Xiao , Zhu Bo , Yuan Haibo 
Published: July 2020

ObjectivesTo estimate the prevalence of overweight/obesity among adolescents and evaluate the associated factors in this group in Changchun City in northeastern China.MethodsA cross-sectional study of 1955 adolescents aged 11–18 years was conducted in Changchun City using stratified cluster sampling. Parents and caregivers of children completed the questionnaires as requested without objection. The questionnaire included demographic characteristics and anthropometric parameters. Univariate and multivariate logistic regression analyses were performed to analyse the relationship between overweight/obesity and related factors.ResultsIn total, the prevalence of overweight was 12.7% (male 17.4%; female 10.1%) and of obesity was 4.9% (male 8.8%; female 3.1%) in Changchun, Jilin Province. The prevalence of overweight and obesity was higher in boys than in girls (p<0.001). Multivariate logistic regression showed that overweight and obesity were significantly associated with male sex (OR=1.91, 95% CI 1.48 to 2.47), eating fresh fruits more than 2 days per week (OR=1.41, 95% CI 1.09 to 1.84) and eating quickly (OR=1.37, 95% CI 1.06 to 1.78). Students who were not picky (OR=0.69, 95% CI 0.53 to 0.90) were less likely to be overweight, and adolescents whose father was overweight or obese (OR=0.67, 95% CI 0.52 to 0.86) or whose mother was overweight or obese (OR=0.72, 95% CI 0.52 to 0.99) were less likely to be overweight.ConclusionThe prevalence of overweight and obesity among adolescents in Changchun has been high in recent years, and the prevalence was higher among boys than among girls. Sex, dietary habits (weekly frequency of fruit consumption, picky eating and slowness in eating) and parental weight were important factors for overweight and obesity in adolescents. Further research should be conducted on the health of adolescents in China, and further intervention measures should be implemented to reduce the prevalence of overweight/obesity.
Cost-effectiveness of rivaroxaban compared with enoxaparin plus warfarin for the treatment of hospitalised acute deep vein thrombosis in China
Authors: Yang Li , Wu Jingjing 
Published: July 2020

ObjectiveLimited economic evaluation data for rivaroxaban compared with standard of care (SoC) exists in China. The objective of this analysis was to evaluate the cost-effectiveness of rivaroxaban compared with current SoC (enoxaparin overlapped with warfarin) for the treatment of acute deep vein thrombosis (DVT) in China.MethodsA Markov model was adapted from a payer’s perspective to evaluate the costs and quality-adjusted life years (QALYs) of patients with DVT treated with rivaroxaban or enoxaparin/warfarin. Clinical data from the EINSTEIN-DVT trial were obtained to estimate the transition probabilities. Data on Chinese health resource use, unit costs and utility parameters were collected from previously published literature and used to estimate the total costs and QALYs. The time horizon was set at 5 years and a 3-month cycle length was used in the model. A 5% discount rate was applied to the projected costs. One-way sensitivity analyses and probabilistic sensitivity analyses were undertaken to assess the impact of uncertainty on results.ResultsRivaroxaban therapy resulted in an increase of 0.008 QALYs and was associated with lower total costs compared with enoxaparin/warfarin (US$4744.4 vs US$5572.4, respectively), demonstrating it to be a cost-saving treatment strategy. The results were mainly sensitive to length of hospitalisation due to DVT on enoxaparin/warfarin, cost per day of hospitalisation and the difference in length of stay of rivaroxaban-treated and enoxaparin/warfarin-treated patients.ConclusionRivaroxaban therapy resulted in a cost saving compared with enoxaparin/warfarin for the anticoagulation treatment of patients with hospitalised acute DVT in China.Trial registration numberNCT00440193; Post-results.
Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis
Authors: Pek Jen Heng , Gan Ming Ying , Yap Bei Jun , Seethor Shu Ting Tammie , Greenberg Rachel G , Hornik Christoph Paul Vincent , Tan Bobby , Lee Jan Hau , Chong Shu-Ling 
Published: July 2020

IntroductionNeonatal sepsis has a high mortality rate that varies across different populations. We aim to perform a contemporary global evidence synthesis to determine the case fatality rates of neonatal sepsis, in order to better delineate this public health urgency and inform strategies to reduce fatality in this high-risk population.Methods and analysisWe will search PubMed, Cochrane Central, Embase and Web of Science for articles in English language published between January 2010 and December 2019. All clinical trials and observational studies involving infants less than 90 days old with a clinical diagnosis of sepsis and reported case fatality rate will be included. Two independent reviewers will screen the studies and extract data on study variables chosen a priori. Quality of evidence and risk of bias will be assessed using Cochrane Collaboration’s tool and ROBINS-I. Results will be synthesised qualitatively and pooled for meta-analysis.Ethics and disseminationNo formal ethical approval is required as there is no collection of primary data. This systematic review and meta-analysis will be disseminated through conference meetings and peer-reviewed publications.PROSPERO registration numberCRD42020164321.
Distress and resilience of healthcare professionals during the COVID-19 pandemic (DARVID): study protocol for a mixed-methods research project
Authors: Fuchs Alexander , Abegglen Sandra , Berger-Estilita Joana , Greif Robert , Eigenmann Helen 
Published: July 2020

IntroductionThe unprecedented COVID-19 pandemic has exposed healthcare professionals (HCPs) to exceptional situations that can lead to increased anxiety (ie, infection anxiety and perceived vulnerability), traumatic stress and depression. We will investigate the development of these psychological disturbances in HCPs at the treatment front line and second line during the COVID-19 pandemic over a 12-month period in different countries. Additionally, we will explore whether personal resilience factors and a work-related sense of coherence influence the development of mental health problems in HCPs.Methods and analysisWe plan to carry out a sequential qualitative–quantitative mixed-methods design study. The quantitative phase consists of a longitudinal online survey based on six validated questionnaires, to be completed at three points in time. A qualitative analysis will follow at the end of the pandemic to comprise at least nine semistructured interviews. The a priori sample size for the survey will be a minimum of 160 participants, which we will extend to 400, to compensate for dropout. Recruitment into the study will be through personal invitations and the ‘snowballing’ sampling technique. Hierarchical linear regression combined with qualitative data analysis, will facilitate greater understanding of any associations between resilience and mental health issues in HCPs during pandemics.Ethics and disseminationThe study participants will provide electronic informed consent. All recorded data will be stored on a secured research server at the study site, which will only be accessible to the investigators. The Bern Cantonal Ethics Committee has waiv ed the need for ethical approval (Req-2020–00355, 1 April 2020). There are no ethical, legal or security issues regarding the data collection, processing, storage and dissemination in this project.Trial registration numberISRCTN13694948.
Age, period and cohort effects in firearm homicide and suicide in the USA, 1983–2017
Authors: Haviland Miriam J , Rowhani-Rahbar Ali , Rivara Frederick P 
Published: July 2020

BackgroundRates of firearm homicide and suicide have varied over time. These variations are due to a number of factors including temporal trends, age, birth year and gender. We sought to conduct an age–period–cohort analysis to understand the intersection of these factors with firearm homicide and suicide.MethodsWe used data on firearm homicide and suicide for the years 1983–2017 from the Centers for Disease Control and Prevention’s Web-based Injury Statistics Query and Reporting System for this analysis. We restricted our analysis on firearm homicide to persons aged 10–44 years and our analysis on firearm suicide to persons aged 50–84 years, as these age groups are most at risk of each outcome. We calculated annual incidence rates for both outcomes per 100 000 population, overall and by gender.ResultsAcross all age groups, rates of firearm homicide increased dramatically in the late 1980s and early 1990s. The peak age for firearm homicide varied across cohorts, although it was generally between ages 15 and 29 years. Rates of firearm homicide were substantially higher among men than women, regardless of age, period or cohort. Firearm suicide rates varied significantly by gender. Among men, older cohorts had higher firearm suicide rates, although the rate of firearm suicide increased with age across all cohorts. Among women, firearm suicide rates were also highest among older cohorts; however, firearm suicide rates decreased or remained relatively constant with age.ConclusionThere are important differences in rates of firearm homicide and suicide with respect to gender, age, period and cohort.
Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
Authors: Malapelle Umberto , Pisapia Pasquale , Iaccarino Antonino , Barberis Massimo , Bellevicine Claudio , Brunnström Hans , de Biase Dario , De Maglio Giovanna , Ericson Lindquist Kajsa , Fassan Matteo , Fontanini Gabriella , Gruppioni Elisa , Hofman Paul , Merkelbach-Bruse Sabine , Molina Vila Miguel A , Pujals Anaïs , Rapa Ida , Righi Luisella , Rosell Rafael , Schildgen Oliver , Schildgen Verena , Schmitt Fernando C , Tallini Giovanni , Vander Borght Sara , Vigliar Elena , Volante Marco , Wagener-Ryczek Svenja , Weynand Birgit , Troncone Giancarlo 
Published: July 2020

AimsLung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.MethodsFifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.ResultsIn most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.ConclusionsThe workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.