bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic precise orbit determination of Hayabusa2 using laser altimeter (LIDAR) and image tracking data sets
Authors: Yamamoto Keiko , Otsubo Toshimichi , Matsumoto Koji , Noda Hirotomo , Namiki Noriyuki , Takeuchi Hiroshi , Ikeda Hitoshi , Yoshikawa Makoto , Yamamoto Yukio , Senshu Hiroki , Mizuno Takahide , Hirata Naru , Yamada Ryuhei , Ishihara Yoshiaki , Araki Hiroshi , Abe Shinsuke , Yoshida Fumi , Higuchi Arika , Sasaki Sho , Oshigami Shoko , Tsuruta Seiitsu , Asari Kazuyoshi , Shizugami Makoto , Ogawa Naoko , Ono Go , Mimasu Yuya , Yoshikawa Kent , Takahashi Tadateru , Takei Yuto , Fujii Atsushi , Yamaguchi Tomohiro , Kikuchi Shota , Watanabe Sei-ichiro , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Saiki Takanao , Tsuda Yuichi 
Published: June 2020

AbstractThe precise orbit of the Hayabusa2 spacecraft with respect to asteroid Ryugu is dynamically determined using the data sets collected by the spacecraft’s onboard laser altimeter (LIght Detection And Ranging, LIDAR) and automated image tracking (AIT). The LIDAR range data and the AIT angular data play complementary roles because LIDAR is sensitive to the line-of-sight direction from Hayabusa2 to Ryugu, while the AIT is sensitive to the directions perpendicular to it. Using LIDAR and AIT, all six components of the initial state vector can be derived stably, which is difficult to achieve using only LIDAR or AIT. The coefficient of solar radiation pressure (SRP) of the Hayabusa2 spacecraft and standard gravitational parameter (GM) of Ryugu can also be estimated in the orbit determination process, by combining multiple orbit arcs at various altitudes. In the process of orbit determination, the Ryugu-fixed coordinate of the center of the LIDAR spot is determined by fitting the range data geometrically to the topography of Ryugu using the Markov Chain Monte Carlo method. Such an approach is effective for realizing the rapid convergence of the solution. The root mean squares of the residuals of the observed minus computed values of the range and brightness-centroid direction of the image are 1.36 m and 0.0270°, respectively. The estimated values of the GM of Ryugu and a correction factor to our initial SRP model are 29.8 ± 0.3 m3/s2 and 1.13 ± 0.16, respectively.
Epidermoid cyst within an intrapancreatic accessory spleen exhibiting abrupt changes in serum carbohydrate antigen 19-9 level: a case report
Authors: Takagi Chisato , Hoshi Nobuo , Kikuchi Yutaro , Shirakawa Hirofumi , Tomikawa Moriaki , Ozawa Iwao , Hishinuma Shoichi , Ogata Yoshiro 
Published: June 2020

Abstract
Background
Epidermoid cyst within an intrapancreatic accessory spleen (ECIAS) is a rare disease. While the detection of solid components relevant to an accessory spleen is a key diagnostic finding, the differential diagnosis between ECIAS and malignant tumors is difficult without resection in patients with no other findings of an accessory spleen.

Case presentation
A 73-year-old male was found to have an elevated carbohydrate antigen (CA) 19-9 level (95 U/mL) at an annual checkup, and a cystic lesion in the pancreatic tail was located by abdominal ultrasound. Abdominal magnetic resonance imaging (MRI) revealed a multicystic mass, 24 mm in diameter, which exhibited varying intensities on T2-weighted images. There were no findings suggesting solid components on contrast-enhanced computed tomography and magnetic resonance imaging. Re-evaluation of serum CA 19-9 level revealed a rapid increase to 901 U/mL, which declined to 213 U/mL 3 weeks later. Ruling out the lesion’s malignant potential was difficult, and the patient underwent distal pancreatectomy with splenectomy. Histological findings revealed an ECIAS including multiple cysts, with the mucinous component of each cyst exhibiting different stages of biological reaction; one ruptured cyst exhibited inflammatory changes.

Conclusions
Careful observation for changes in serum CA 19-9 level and MRI findings might facilitate the diagnosis of ECIAS without a solid component by imaging studies.
Cell-free microRNA-21: biomarker for intracranial aneurysm rupture
Authors: Jin Hengwei , Jiang Yuhua , Liu Xinke , Meng Xiangyu , Li Youxiang 
Published: June 2020

Abstract
Background
Deregulation of miRNA-21 expression has been reported to be associated with vascular smooth muscle behavior and cytoskeletal stability. This study is aimed to investigate the density of serum miRNA-21 in patients with different phases of intracranial aneurysms (IAs) and explore its warning function for IA rupture.

Methods
A total of 16 in 200 IA patients were selected and categorized into 4 groups based on the phase of IA. Microarray study was carried out using serum miRNA and differentially expressed miRNAs were identified. Another 24 samples from a cohort of 360 patients were added and real-time polymerase chain reaction (RT-PCR) was performed on expanded sample size (n = 40) for miRNA-21 validation. Potential gene targets of miRNA-21 were screened out from Gene Ontology (GO) database and literatures.

Results
Microarray study identified 77 miRNAs with significantly different expression levels between experimental groups and the control group. RT-PCR assays validated significant downregulation of miRNA-21 in experimental groups, among which miRNA-21 expression level of daughter aneurysm group decreased the most. Bioinformatic analyses revealed that several target genes related with miRNA-21 may be involved in IA formation and rupture.

Conclusions
This study suggested that miRNA-21 had a protective effect for intracranial vascular wall against remodeling and warning function for intracranial aneurysm rupture. Significant suppression of serum miRNA-21 in IA patients may provide diagnostic clues for aneurysm rupture and guide clinical intervention.
Poisson magnetization-to-density-ratio and magnetization inclination properties of banded iron formations of the Carajás mineral province from processing airborne gravity and magnetic data
Authors: Alencar de Matos Caio , Mendonça Carlos Alberto 
Published: June 2020

According to the Poisson theorem, gravity and magnetic fields arising from geologic bodies that share common sources, with a uniform magnetization-to-density ratio (MDR) and a uniform magnetization direction, are related by a linear transformation that allows each field to be calculated from the other. Provided that these conditions on the sources are met, when the gravity and magnetic data are available over an area, the Poisson theorem can be used to infer the MDRs and magnetization directions of sources from their associated gravity and magnetic anomalies. These conditions are partially met in many geologic structures but are expected in iron ore deposits, usually associated with strongly magnetic and highly dense formations. Due to the importance of iron ore as a global commodity, most mineral provinces of the world have been investigated by accurate gravity and magnetic sensors, providing a reliable database, but they have not yet been explored with joint interpretation based on Poisson’s relationships. We have interpreted a gravity-magnetic survey covering the Serra Sul of the Carajás Mineral Province, Brazil, where world-class iron deposits are found. We have adapted a formulation formerly developed to estimate the MDR and the magnetization inclination (MI) from profile data to process gridded data sets. Due to faulting and folding, the same density and magnetic structure may assume different strike directions, requiring corrections to improve MDR and MI estimates. Because the geomagnetic field inclination in the studied area is very low (−6.7°), a procedure for stable computation of the components of the anomalous magnetic field vector is applied. The inferences for Serra Sul MDR suggest minor variations for the entire 30 km long formation containing the mineralized bodies, the strong remanent magnetization showing reverse polarity for banded iron formation segments of the Carajás Serra Sul.
Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts
Authors: Garbe Claus , Keim Ulrike , Suciu Stefan , Amaral Teresa , Eigentler Thomas K. , Gesierich Anja , Hauschild Axel , Heinzerling Lucie , Kiecker Felix , Schadendorf Dirk , Stadler Rudolf , Sunderkötter Cord , Tüting Thomas , Utikal Jochen , Wollina Uwe , Zouboulis Christos C. , Keilholz Ulrich , Testori Alessandro , Martus Peter , Leiter Ulrike , Eggermont Alexander M. M. ,   on behalf of the German Central Malignant Melanoma Registry and the European Organisation for Research and Treatment of Cancer
Published: June 2020

PURPOSE Three new therapies have been approved recently for the adjuvant treatment of stage III melanoma, substantially reducing the risk of tumor recurrences. This study evaluates 3 independent data sets to clarify the survival probabilities of patients with stage III melanoma. PATIENTS AND METHODS The Central Malignant Melanoma Registry (CMMR) evaluated 1,553 patients with a primary diagnosis of stage III melanoma from 2000 to 2012. Studies from the European Organisation for Research and Treatment of Cancer (EORTC), of 573 patients in the observation arm of the 18991 study and 445 patients in the placebo arm of the 18071 study, were evaluated as reference cohorts. The survival outcomes were compared with the published American Joint Committee on Cancer version 8 (AJCCv8) stage III survival data. RESULTS For the CMMR stage III cohort versus the AJCCv8 cohort, the melanoma-specific survival (MSS) rates at 5 years were 67% versus 77%, and at 10 years were 56% versus 69%, respectively. For stage IIIA, the MSS rates at 5 years were 80% versus 93%, and at 10 years were 71% versus 88%; for stage IIIB, the MSS rates at 5 years were 75% versus 83%, and at 10 years were 61% versus 77%. The MSS rates of the EORTC studies either overlapped with or were lower than, the CMMR data. CONCLUSION The MSS rates in the CMMR and EORTC cohorts over the entire stage III are less favorable than those published in AJCCv8. This is particularly true for substages IIIA and IIIB.
Prospective Evaluation of Radiation Dose Escalation in Patients With High-Risk Neuroblastoma and Gross Residual Disease After Surgery: A Report From the Children’s Oncology Group ANBL0532 Study
Authors: Liu Kevin X. , Naranjo Arlene , Zhang Fan F. , DuBois Steven G. , Braunstein Steve E. , Voss Stephan D. , Khanna Geetika , London Wendy B. , Doski John J. , Geiger James D. , Kreissman Susan G. , Grupp Stephan A. , Diller Lisa R. , Park Julie R. , Haas-Kogan Daphne A. 
Published: June 2020

PURPOSE A primary objective of the Children’s Oncology Group (COG) ANBL0532 phase III study was to assess the effect of increasing local dose of radiation to a residual primary tumor on the cumulative incidence of local progression (CILP) in patients with high-risk neuroblastoma. PATIENTS AND METHODS Newly diagnosed patients with high-risk neuroblastoma were randomly assigned or assigned to receive single or tandem autologous stem-cell transplantation (SCT) after induction chemotherapy. Local control consisted of surgical resection during induction chemotherapy and radiotherapy after last SCT. Patients received 21.6 Gy to the preoperative primary tumor volume. For patients with incomplete surgical resection, an additional boost of 14.4 Gy was delivered to the gross residual tumor, for a total dose of 36 Gy. CILP (primary end point) and event-free (EFS) and overall survival (OS; secondary end points) were compared with the COG A3973 historical cohort, in which all patients received single SCT and 21.6 Gy without a boost. RESULTS For all patients in ANBL0532 receiving radiotherapy (n = 323), 5-year CILP, EFS, and OS rates were 11.2% ± 1.8%, 56.2% ± 3.4%, and 68.4% ± 3.2% compared with 7.1% ± 1.4% ( P = .0590), 47.0% ± 3.5% ( P = .0090), and 57.4% ± 3.5% ( P = .0088) for all patients in A3973 receiving radiotherapy (n = 328), respectively. Five-year CILP, EFS, and OS rates for patients in A3973 with incomplete resection and radiotherapy (n = 47) were 10.6% ± 4.6%, 48.9% ± 10.1%, and 56.9% ± 10.0%, respectively. In comparison, 5-year CILP, EFS, and OS rates for patients in ANBL0532 who were randomly assigned or assigned to single SCT and received boost radiotherapy (n = 74) were 16.3% ± 4.3% ( P = .4126), 50.9% ± 7.0% ( P = .5084), and 68.1% ± 6.7% ( P = .2835), respectively. CONCLUSION Boost radiotherapy to gross residual tumor present at the end of induction did not significantly improve 5-year CILP. These results highlight the need for new strategies to decrease the risk of locoregional failure.
Feasibility and Value of Establishing a Community-Based Virtual Multidisciplinary Sarcoma Case Conference
Authors: Pan Minggui , Seto Tiffany , Yu Jeanette , Sidhu Manpreet , Kim Brian , McCormick Craig , Fang Andrew , Song Joseph , Morse Lee Jae , Peng Peter D. , Chakedis Jeffery , Huber Ryan , Schwartz Corey , Lee Jason D. , Zou Youran 
Published: June 2020

PURPOSE: Management of soft tissue and bone sarcoma presents many challenges, both diagnostically and therapeutically, and requires multidisciplinary collaboration; however, such collaboration is often challenging to establish, especially in the community setting. We share our experiences of a virtual multidisciplinary sarcoma case conference (VMSCC). METHODS: We conducted retrospective review of the VMSCC data—initially via Webex, now Microsoft Teams—and the surveys of referring physicians to understand the feasibility and value of the VMSCC. RESULTS: The VMSCC was established in March 2013 in Kaiser Permanente Northern California with consistent participation of the Departments of Musculoskeletal Oncology (orthopedic oncology), Musculoskeletal Radiology, Pathology, Medical Oncology, Radiation Oncology, Nuclear Medicine, Surgical Oncology, and Genetics. Pediatric Oncology participated ad hoc when pediatric sarcoma cases were presented. Referrals were from multiple specialties and regions, including the Kaiser Permanente Mid-Atlantic and Hawaii regions. From March 2013 to December 2019, 1,585 cases were reviewed encompassing 36 histologic types. More than 300 cases were reviewed per year from 2017 to 2019. Survey results of referring physicians demonstrate that the VMSCC enhanced the confidence of treating physicians, and its recommendations frequently led to treatment changes. CONCLUSION: Establishing a valuable community-based VMSCC is feasible. VMSCC recommendations frequently led to treatment changes and improved the confidence of treating physicians.
Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity
Authors: van der Heijden Charlotte D C C , ter Horst Rob , van den Munckhof Inge C L , Schraa Kiki , de Graaf Jacqueline , Joosten Leo A B , Danser A H Jan , Netea Mihai G , Deinum Jaap , Rutten Joost , Riksen Niels P 
Published: June 2020

Abstract

Context
Not all obese individuals develop cardiovascular disease (CVD). Hyperaldosteronism is suggested to cause inflammation and metabolic dysregulation, and might contribute to CVD development in obese individuals.

Objective
We aimed to investigate the association of aldosterone concentrations with inflammation, metabolic disturbances, and atherosclerosis in overweight and obese individuals. Additionally, we measured renin concentrations to investigate whether the observed effects reflected general activation of the renin-angiotensin-aldosterone system (RAAS).

Design
A cross-sectional cohort study (300-OB study) was conducted. Various inflammatory parameters, traits of the metabolic syndrome, lipidome and metabolome parameters, fat distribution, and carotid atherosclerosis were associated with plasma aldosterone and renin levels.

Setting
The setting of this study was the Radboudumc (i.o. Radboudumc), the Netherlands.

Patients
A total of 302 individuals with a body mass index greater than or equal to 27 kg/m2 participated.

Main Outcome Measures and Results
Aldosterone was associated with various markers of inflammation and metabolic dysregulation, which partly differed from the associations observed for renin. Although both were associated with inflammatory cell numbers, only renin was associated with classical markers of systemic inflammation. Both were associated with the metabolic syndrome and hepatic steatosis. Of the traits that constitute metabolic syndrome, aldosterone, but not renin, was associated with triglyceride concentrations. Accordingly, aldosterone was associated with large very low-density lipoprotein particles; metabolomics studies further associated aldosterone with urate concentrations and derivatives of the linoleic acid metabolism pathway. Neither aldosterone nor renin was associated with atherosclerotic plaque thickness.

Conclusions
Aldosterone is not an important driver of systemic inflammation in the obese, whereas aldosterone concentrations and metabolic dysregulation are strongly intertwined in these individuals. Although prospective studies are necessary to validate these results, the independent effects of aldosterone on carotid atherosclerosis appear modest.
Steroid Screening Tools Differentiating Nonclassical Congenital Adrenal Hyperplasia and Polycystic Ovary Syndrome
Authors: Maffazioli Giovana D N , Bachega Tania A S S , Hayashida Sylvia A Y , Gomes Larissa G , Valassi Helena P L , Marcondes Jose A M , Mendonca Berenice B , Baracat Edmund C , Maciel Gustavo A R 
Published: June 2020

Abstract

Purpose
To analyze the performance of basal 17OH-progesterone (17OHP) levels versus the basal 17OHP/cortisol ratio in nonclassical congenital adrenal hyperplasia (NCAH) and polycystic ovary syndrome (PCOS) differential diagnosis. Basal 17OHP levels &gt;10 ng/mL have been used to confirm NCAH diagnosis without the adrenocorticotropic hormone (ACTH) test; however, the optimal cutoff value is a matter of debate.

Methods
A cross-sectional study was performed at the endocrinology and gynecological endocrinology outpatient clinics of a tertiary hospital. A total of 361 patients with PCOS (age 25.0 ± 5.3 years) and 113 (age 19.0 ± 13.6 years) patients with NCAH were enrolled. Basal and ACTH-17OHP levels were measured by radioimmunoassay, and CYP21A2 molecular analysis was performed to confirm hormonal NCAH diagnosis. Receiver operating characteristic curve analysis compared basal 17OHP levels and the 17OHP/cortisol ratio between NCAH and PCOS patients.

Results
Basal 17OHP levels were higher in NCAH patients than in those with PCOS (8.85 [4.20-17.30] vs 1.00 [0.70-1.50] ng/mL; P &lt; 0.0001), along with 17OHP/cortisol ratio (0.86 [0.47-1.5]) vs 0.12 [0.07-0.19]; P &lt; 0.0001, respectively). Basal 17OHP levels and the 17OHP/cortisol ratio were strongly correlated in both groups (rho = 0.82; P &lt; 0.0001). Areas under the curves for basal 17OHP levels (0.9528) and the 17OHP/cortisol ratio (0.9455) were not different to discriminate NCAH and PCOS (P &gt; 0.05). Basal 17OHP level &gt;5.4 ng/mL and 17OHP/cortisol ratio &gt;2.90 had 100% specificity to identify NCAH.

Main Conclusions
Basal 17OHP levels &gt;5.4 ng/mL can be used to perform differential diagnoses between NCAH and PCOS, dismissing the ACTH test. The basal 17OHP/cortisol ratio was not superior to basal 17OHP levels in this scenario.
Anabiosis and the Liminal Geographies of De/extinction
Authors: Searle Adam 
Published: June 2020

AbstractThe spectacle of de-extinction is often forward facing at the interface of science fiction and speculative fact, haunted by extinction’s pasts. Missing from this discourse, however, is a robust theorization of de-extinction in the present. This article presents recent developments in the emergent fields of resurrection biology and liminality to conceptualize the anabiotic (not living nor dead) state of de/extinction. Through two stories, this article explores the epistemological perturbation caused by the suspended animation of genetic material. Contrasting the genomic stories of the bucardo, a now extinct subspecies of Iberian ibex whose genome was preserved before the turn of the millennium, and the woolly mammoth, whose genome is still a work in progress, the author poses questions concerning the existential authenticity of this genomic anabiosis. They serve as archetypal illustrations of salvaged and synthesized anabiotic creatures. De/extinction is presented as a liminal state of being, both living and dead, both fact and fiction, a realm that we have growing access to through the proliferation of synthetic biology and cryopreservation. The article concludes through a presentation of anabiotic geographies, postulating on the changing biocultural significances we attach to organisms both extinct and extant, and considering their implications for the contemporary extinction crisis.
How Does Firms’ Innovation Disclosure Affect Their Banking Relationships?
Authors: Saidi Farzad , Žaldokas Alminas 
Published: June 2020

Firms face a trade-off between patenting, thereby disclosing innovation, and secrecy. We show that this trade-off interacts with firms’ financing choices. As a shock to innovation disclosure, we study the American Inventor’s Protection Act that made firms’ patent applications public 18 months after filing, rather than when granted. We find that such increased innovation disclosure helps firms switch lenders, resulting in lower cost of debt, and facilitates their access to syndicated-loan and public capital markets. Our evidence lends support to the idea that public-information provision through patents and private information in financial relationships are substitutes, and that innovation disclosure makes credit markets more contestable. This paper was accepted by Gustavo Manso, finance.
The Impact of Uniform Pricing Regulations on Incentives to Generate and Disclose Accounting Information
Authors: Arya Anil , Mittendorf Brian , Yoon Dae-Hee 
Published: June 2020

A persistent question in industrial organization is whether regulations restricting price discrimination in input markets can promote efficiency. Despite the extensive study of the economic effects of input pricing regulations, the literature is bereft of an examination of the role of accounting information. In this paper, we seek to fill the gap by modeling the effects of uniform pricing restrictions in input markets on firms’ information generation and disclosure. In doing so, we find that information considerations present an impetus for uniform pricing requirements since they promote incentives for retail firms to both acquire and disclose relevant accounting information. In effect, by shielding retail firms from excessive supplier exploitation, uniform pricing regulations create a richer and more transparent information environment. This, then, leads to welfare gains and even benefits that can accrue naturally to all supply chain partners including the supplier, whose actions are constrained by the uniform pricing regulation. This paper was accepted by Brian Bushee, accounting.