bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Opium Consumption and Coronary Artery Ectasia: A Propensity Score-matched Study
Authors: Shafie Mahan , Aminorroaya Arya , Vasheghani-Farahani Ali , Jalali Arash , Baradaran Abdolvahab 
Published: December 2020

Abstract
Background: Opium consumption is associated with an increased risk of atherosclerosis and a hyper-inflammatory state that are suggested as contributing factors to the development of coronary artery ectasia (CAE). We aimed to determine if opium consumption is an independent risk factor of CAE. Methods: In this propensity score-matched study, we enrolled patients who underwent elective coronary angiography between September 2004 and March 2017 in Tehran Heart Center. We studied patients with CAE and without coronary artery disease as cases. The control group, patients with normal coronary angiograms, were selected after applying the propensity score matching to match for age, sex, diabetes mellitus, hypertension, hyperlipidemia, family history of coronary artery disease, and cigarette smoking.Results: We studied 242 patients with pure CAE and selected 968 control patients. The prevalence of opium consumption was not significantly different across these groups, 17 (7.5%) in the pure CAE group compared to 76 (8.6%) in the control group (Odds ratio: 0.81; p=0.455). Amongst the patients with pure CAE, Markis scores were not significantly different between opium consumers and non-consumers (p=0.136).Conclusions: We found no significant difference regarding opium consumption between patients with pure CAE and patients with normal coronary angiograms. In addition, there is no correlation between opium consumption and Markis scores in patients with pure CAE.
Evaluation of uterine scar healing by transvaginal ultrasound in 607 nonpregnant women with a history of cesarean section
Authors: Zhou Xingchen , Zhang Tao , Qiao Huayuan , Zhang Yi , Wang Xipeng 
Published: December 2020

Abstract
Background: Caesarean scar defect (CSD) seriously affects female reproductive health. In this study, we aim to evaluate uterine scar healing by transvaginal ultrasound（TVS）in nonpregnant women with cesarean section（CS）history and to build a predictive model for cesarean section defects is very necessary. Methods: A total of 607 nonpregnant women with previous CS who have transvaginal ultrasound measurements of the thickness of the lower uterine segment . The related clinical data were recorded and analyzed. Results: All patients were divided into two groups according to their clinical symptoms: Group A (N=405) who had no cesarean scar symptoms, and Group B (N=141) who had cesarean scar symptoms. The difference in frequency of CS, uterine position, detection rate of CSD and the the residual muscular layer (TRM) of the CSD were statistically significant between groups; the TRM measurements of the two groups were (mm) 5.39±3.34 vs 3.22±2.33, P<0.05.All patients were divided into two groups according to whether they had CSDs: Group C (N=337) who had no CSDs , Group D (N=209) who had CSDs on ultrasound examination. The differences in frequency of CS, uterine position, TRM between groups were statistically significant (P<0.05). In the model predicting CSDs by TRM with TVS, the area under the ROC curve was 0.771, the cut-off value was 4.15 mm. The sensitivity and specificity were 87.8% and 71.3%,respectively.Conclusions: Patients with no clinical symptoms had a mean TRM on transvaginal ultrasonography of 5.39 ± 3.34 mm, which could be used as a good reference to predict the recovery of patients with CSDs after repair surgery.
Clinical File Management, Translational Research and Continuing Education for Cancer: a Single-unit Experience
Authors: Tong Dali 
Published: December 2020

Abstract
Background: Cancer is considered clinically heterogeneous. Some cancers are indolent and localized, while others are aggressive and easily spread to other parts of the body with metastasis. Whether diagnosis methods or therapy selection has moved towards combination, personalization and diversity. Therefore, it is important to standardize clinical file management, biospecimen collection and translational research of cancer.Methods: Data were retrieved from the Clinical Study Project on Cancer in XXXX, an ongoing longitudinal study including more than 1500 genitourinary cancer people.Results: The standard clinical diagnosis, treatment and translational research workflow was built based on current medical administration technology, molecular research method and triangle coordination relationship among doctor, patient and researcher. Raised awareness of warning signs and improved healthy styles showed high-quality follow-up and clinical outcome. At last, the system helps research ability improvement based on the skills proficiency and achieve medicine-research-education integration. Conclusion: Our analysis will help ensure patient health, enhance doctor-patient relationship, improve research efficiency and support continuing education. The goal of sustainable work participation in cancer survivors can be improved by the delivery of a personalised clinical management and education intervention. Furthermore, successful work outcomes often involve the cooperation of doctors, cancer survivors and clinical researchers.
High Burden of Gastrointestinal Helminth Parasites in Catfishes: Clarias gariepinus and Heteropneustes fossilis
Authors: Shah Gayatri , Labh Shyam Narayan 
Published: December 2020

Abstract
Objective: Catfishes harbour a greater variety and occurrence of larval helminth parasites because they are exposed to more infective helminth larvae in their diet due to their predatory habit which makes them more susceptible to higher parasitic burden. This study was conducted at department of zoology in Post Graduate Campus, Biratnagar, Nepal to determine the prevalence of helminth parasites in the gastrointestinal tract of two species of catfishes i.e Clarias gariepinus and Heteropneustes fossilis collected from the different water resources of Biratnagar, Eastern Nepal.Results: Out of 280 fish examination, 264 (94.28%) fishes were found to be infected with helminths parasites. Clarias gariepinus infection rate was 84.0% with three species of parasites, one each of nematode i.e. Procamallanus laevionchus, cestode i.e. Proteocephalus species, and trematode i.e. Allocreadium species. Heteropneustes fossilis have prevalence rate of 100% with five species of helminth parasites i.e. two nematode species namely Procamallanus heteropneustes and Eustrongyloides species, one cestode namely Lytocestus indicus, one trematode i.e. Phyllodystomum folium and an acanthocephalan i.e. Pomphorhynchus species were detected.
Culture as an Obstacle for Entrepreneurship
Authors: Morales Gloria Leonor Ortiz , Aguilar Juan Carlos Ramos , Morales Katherin Yineth Lozada 
Published: December 2020

Abstract
This research was aimed to identify the main reasons why entrepreneurs in the city of Ibagué, who structure business ideas and participate in contests and/or calls, do not continue the entrepreneurial process until the creation of their companies. After applying the beforehand validated instrument to more than 100 students from the Universidad de Ibagué and expert advisers from the department of Tolima, made up of universities, entrepreneurs, and public-private institutions, with interests in entrepreneurship; it was possible to recognize that the main reason, why entrepreneurs generate ideas, but not companies, is the cultural factor. The foregoing is based on the fact that Tolima has been a quintessential agricultural department and this situation has contributed greatly to the fact that the entrepreneurial spirit has not been developed in people. Within the research results it was detected that in contrast with other cities of Colombia, like Manizales and Medellín, Ibagué has not been able to consolidate a solid entrepreneurial ecosystem due to the lack of coordination among private, public and academic sectors, and on the other side, the majority of people from Ibagué do not have family support for the development of their initiatives, being fundamental components for the creation of enterprises. Among the recommendations proposed in the study is the construction of an entrepreneurial ecosystem, because it will allow the participation of the Triple Helix by providing opportunities to all entrepreneurs in the region; in addition, it is considered important that educational institutions, both schools and universities, promote the development of entrepreneurial skills and competencies in individuals involving their families.
Results of Favipiravir Combined Treatment in Intensive Care Patients With Covid-19
Authors: Yilmaz Habip , Güner Emre , Altuntas Murat 
Published: December 2020

Abstract
Aim: Covid-19 (Coronavirus disease 2019) is a disease that has already taken place in human history. Although there is still no effective treatment and vaccine protocol, different treatment options are being tried. In this study, it was aimed to determine the basic characteristics and changes in laboratory findings of patients who were hospitalized with the diagnosis of Covid-19 in the intensive care unit and underwent treatment protocol containing favipiravir.Material and Method: It was carried out with the data of 179 inpatients in an intensive care unit between 01.06.2020 - 30.06.2020. The inclusion criterias of the study are to have a diagnosis of COVID-19 confirmed by PCR test, to be hospitalized in the intensive care unit, receiving therapy combined with favipravir and to have access to its data through the automation system. According to literature; the sociodemographic characteristics, some basic characteristics and some laboratory findings of the patients were evaluated. Statistical analyzes were performed using the Statistical Package for Social Sciences (SPSS) version 24.0 (IBM Corp .; Armonk, NY, USA).Findings: The average age of the study group is 60.9±16.4 years and 65.9% (n:118) of them are male. According to the clinical classification, more than half (50.8%, n: 91) are included in the "high" clinical classification. The most common chronic disease is "hypertension (HT)" (42.5%, n:76) and the most common symptom is "fever" (57.5%, n: 103). While 82.7% (n: 148) have widespread CT (Computed tomography) findings, CPR (C-Reactive protein) positivity rate is 65.4% (n: 117). Statistical significant difference was detected between three measurements of blood urea nitrogen (BUN), aspartat aminotransferase (AST), alanin aminotransfrase (ALT), CRP between the 1st and the 3rd day. Conclusion: Favipiravir demonstrates a proper safety profile. However, its side effects teratogenicity, hyperuricaemia and QTc (corrected QT interval) prolongation have not yet been adequately studied. It may be safe and tolerable in short-term use, but more evidence is needed to assess the longer-term effects of treatment.
Aged Zinc Oxide Nanoparticles Did Not Induce Cytotoxicity Through Apoptosis Signaling Pathway as Fresh NPs
Authors: Wang Juan , Wang Lei , Zhao Wenting , Cheng Meiling , Su Mingqin , Hu Jian , Yu Na , Du Hua , Wang Meimei 
Published: December 2020

Abstract
Zinc oxide nanoparticles (ZnO NPs) are being used in a wide range of applications including industry, commercial products and medicine field. Numerous mechanistic studies for ZnO NPs’ toxicity are performed on pristine (fresh) NPs. However, the cytotoxicity induced by the transformed (aged) ZnO NPs and the underlying mechanisms remain unclear. Here, we firstly confirmed the physicochemical transformation of ZnO NPs underwent over time and compared the cytotoxicity induced by fresh and aged NPs. Then, we found that fresh NPs induced higher apoptosis levelthan aged NPs. Accordingly, RNA sequencing data from aged ZnO NP-treated human-hamster hybrid (AL) cells showed that p53, PI3k-Akt, FoXO, Glutathione, ErbB, HIF-1, Oxytocin and Jak-STAT signaling pathway were enriched but no apoptosis pathway. Quantitative PCR results confirmed the significantly higher mRNA level of IL1B and CD69 in fresh NP-treated groups compared to that of aged ZnO NP- and zinc chloride-treated groups. Our data indicated that the lower cytotoxicity of aged ZnO NPs is closely related to the low level of apoptosis induced by it and that the transcriptional regulation of the multiple pathways activated by aged NPs helps to build the cellular homeostasis. Our results highlight the aging (environmental transformation) process to the toxicity and safety assessment of ZnO NPs.
Leaf and community photosynthetic carbon assimilation of alpine plants under in-situ warming
Authors: Zijuan Zhou , Peixi Su , Xiukun Wu , Rui Shi , Xinjing Ding 
Published: December 2020

Abstract
Background: The Tibetan Plateau is highly sensitive to elevated temperatures and has experienced significant climate warming in the last decades. While climate warming is known to greatly impact alpine ecosystems, the gas exchange responses at the leaf and community levels to climate warming in alpine meadow ecosystems remain unclear.Results: In this study, the alpine grass, Elymus nutans, and forb, Potentilla anserina, were grown in open-top chambers (OTCs) for three consecutive years to evaluate their response to warming. Gas exchange measurements were used to assess the effects of in-situ warming on leaf- and community-level photosynthetic carbon assimilation based on leaf traits and photosynthetic physiological parameters. We introduced a means of up-scaling photosynthetic measurements from the leaf level to the community level based on six easily-measurable parameters, including leaf net photosynthetic rate, fresh leaf mass per unit leaf area, fresh weight of all plant leaves, the percentage of healthy leaves, the percentage of received effective light by leaves in the community, and community coverage. The community-level photosynthetic carbon assimilation and productivity all increased with warming, and the net photosynthetic rate at the leaf level was significantly higher than at the community level. Under elevated temperature, the net photosynthetic rate of E. nutans decreased, while that of P. anserina increased.Conclusions: These results indicated that climate warming may significantly influence plant carbon assimilation, which could alter alpine meadow community composition in the future.
Effects of a specific task-oriented training versus its combination with manual therapy on balance and mobility in people post stroke at the chronic stage: study protocol for a pilot randomised controlled trial
Authors: Traxler Kristina , Schinabeck Franz , Baum Eva , Klotz Edith , Seebacher Barbara 
Published: December 2020

Abstract
Background: Large studies have shown that stroke is among the most relevant causes of acquired adult disability. Walking and balance impairment in stroke survivors often contribute to a restriction in daily activities and social participation. Task-oriented training (TOT) is an effective treatment strategy and manual therapy (MT) is used successfully to enhance ankle joint flexibility in this population. No study, however, has compared TOT against its combination with MT in a randomised controlled trial. Aims of this pilot study are therefore to explore the feasibility of a full-scale RCT and the preliminary effects of specific TOT with a combined specific TOT-MT versus a control group in people post stroke.Methods: This is a protocol of a 4-week prospective randomised controlled parallel pilot trial in people post stroke at the chronic stage with limited upper ankle joint mobility and an impairment in balance and mobility. At a German outpatient therapy centre using 1:1:1 allocation, 36 patients will be randomised into one of three groups: 15-minute talocrural joint MT plus 30-minute specific TOT (Group A); 45-minute specific TOT (Group B); controls (Group C). Training will be goal-oriented including tasks that are based on daily activities and increased in difficulty ulilising predefined progression criteria. Interventions will be provided face-to-face 2 times per week, for 4 weeks, in addition to 20-minute concurrent x4 weekly homebased training sessions. Data will be collected by blinded assessors at baseline, post-intervention and 4-week follow-up. The primary outcome will be feasibility assessed by recruitment, retention and adherence rates, compliance, adverse events, falls and the acceptability of the intervention. Secondary outcomes will be walking speed, single and dual tasking functional mobility, ankle range of motion, disability and health-related quality of life.Discussion: Results from this study will inform a larger randomised controlled trial to investigate the effects of specific TOT and specific TOT-MT compared to a post stroke control group. We hope that the study findings help to enhance stroke rehabilitation.Trial registration: German Clinical Trials Register, DRKS00023068. Registered on 21.09.2020, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00023068.
Over-expression of Wilms' tumor 1-associating Protein Promotes Tumorigenesis and Predicts Poor Prognosis in Endometrial Cancer
Authors: Xie Wenli , Liu Naifu , Wang Xiangyu , Xie Wenyan , Li Dapeng , Sheng Xiugui 
Published: December 2020

Abstract
Background. Wilms’ tumor 1‐associating protein (WTAP) was previously reported to play critical roles in the tumorigenesis of different malignancies, and its expression level has been linked to a poor prognosis of several cancers. We evaluated the role of WTAP in endometrial carcinoma (EC) using publicly available data from The Cancer Genome Atlas (TCGA). Methods. The relationship between WTAP expression and clinical characteristics was assessed with the Wilcoxon signed‐rank test and logistic regression. Clinical factors associated with prognosis were evaluated using Cox regression analysis and Kaplan-Meier method. Gene set enrichment analysis (GSEA) was conducted using TCGA dataset. Results. Our results revealed that WTAP was significantly up-regulated in EC. Increased WTAP expression in EC was significantly associated with high-grade tumor (odds ratio [OR] = 2.126) and high-risk histology (OR = 1.915) (all P < 0.05). Patients with high WTAP expression had a worse overall survival (OS) (hazard ratio [HR] = 2.868, 95% confidence interval [CI] = 1.259-6.532; P = 0.0087) and recurrence-free survival (RFS) (HR =3.148, 95% CI = 1.372-7.220; P = 0.004) than those with low WTAP expression. Multivariate analysis showed that WTAP expression remained an independent predictor of OS and RFS. Furthermore, GSEA showed that wnt/β-catenin signaling pathway was differentially enriched in WTAP high expression phenotype. Conclusions. WTAP was over-expressed in EC. WTAP expression was an independent predictor of poor OS and RFS in EC, and it was associated with advanced grade, high-risk EC. Moreover, the wnt/β-catenin signaling pathway might be the key process regulated by WTAP in EC.
Clinical value of lncRNA ZFAS1 in various cancers: an updated meta-analysis of 2263 cancer patients
Authors: Liu Zhou , Lu Biyun , Chen Kaiyuan , Gao Weilong , Pan Sisi , Liang Guiyou 
Published: December 2020

Abstract
Background: LncRNA ZNFX1 antisense RNA 1 (ZFAS1) is largely reported to be abnormally expressed in various human cancers and associated with unfavorable prognosis. So this study aims to further investigate its clinical value in multifarious cancers.Methods: Databases of PubMed, Web of science, Cochrane library, Embase, Chinese National Knowledge Infrastructure and Wanfang was retrieved to collect eligible studies until October 22, 2020. The clinical role of ZFAS1 was comprehensively assessed by STATA 12.0. Additionally, the CeRNA network in which ZFAS1 involved was constructed. And function analysis of targeted mRNAs was performed by R package “cluster profiler”.Results: 23 studies of 2263 cancer patients met the inclusion criteria in this meta-analysis. The comprehensive results suggested that patients with elevated ZFAS1 expression got poor overall survival (OS) (HR=1.80, 95%CI: 1.50-2.10, P≤0.001), and they are prone to lymph node metastasis (OR=2.67, 95%CI: 1.73-4.14, P≤0.001), distant metastasis (DM) (OR=3.45, 95%CI: 1.61-7.39, P=0.001), advanced TNM stage (HTS) (OR=2.99, 95%CI: 1.97-4.54, P≤0.001), larger tumor size (LTS) (OR=1.54, 95%CI: 1.05-2.24, P≤0.001), poor histologic grade (PHG) (OR=1.57, 95%CI: 1.09-2.26, P=0.015). The CeRNA network and function analysis revealed the potential mechanism which ZFAS1 may involve in cancers.Conclusion: The current analysis revealed that elevated ZFAS1 expression is common in various cancer and was significantly associated with poor OS and clinical characteristics, thus it may function as prognostic biomarker in various cancer. Nevertheless, larger well-designed clinical research a is still warranted to verify our findings.
Paraganglioma in the Lumbar Spinal Canal&nbsp;Treated by Surgery Assisted by MRI Neuroimaging and 3D Printing Reconstruction:&nbsp;A Case Report&nbsp;and Literature Review
Authors: Zhang Ya , Li Dongqi , Li Kun , Ye Lijuan , Wang Cao , Yang Yihao , Chen Qiuyun , Liu Yan , Wang Tiying , Li Kecheng , Tan Zunxian , Zhu Yanan , Chen Jiaxiang , Yu Xinchao , Yang Zuozhang 
Published: December 2020

Abstract
Background: Ganglion cell paraganglioma is a subtype of neuroendocrine tumors, which is rare in clinical practice. Paraganglioma in the spinal area, especially in the spinal canal, is even rarer.Case presentation:The case we reported was a 46-year-old female who was admitted to the hospital due to "physical examination found a mass in the lumbar spinal canal for more than 2 months." After admission, the relevant examinations and preoperative preparations were perfected, and the posterior L2-3 spinal mass resection + spinal decompression + nail rod system internal fixation was performed. The patient recovered well after the operation, and there was no tumor recurrence in follow-up. Conclusions:Surgical treatment assisted by MRI neuroimaging and 3D printing reconstruction technology may be an effective way to treat paraganglioma in the lumbar spinal canal.
Prognostic Autophagy-Related Genes of Gastric Cancer Patients on Chemotherapy
Authors: Liu xiaolong , Ma Zhen , Zhang Lei , Yu Yang , Paul Maswikiti Ewetse , Ma YanLin , Leng Yufang , Chen Hao 
Published: December 2020

Abstract
Background Chemotherapy resistance based on fluorouracil and cisplatin is one of the most encountered postoperative clinical problems in patients diagnosed with gastric cancer (GC), resulting in poor prognosis. Methods This study aimed to combine autophagy-related genes (ATGs) to investigate the susceptibility of victims with gastric malignancy to postoperative chemotherapy. Based on the TCGA database, gene expression data for GC patients undergoing and during chemotherapy were integrated and analyzed. Prognostic genes were screened based on univariate and various analysis regression models. Subjects were divided into high-risk and low-risk groups and analyzed by the median risk score approach. The product limit estimator method was used to evaluate the OS and DFS. The accuracy of the prediction was resolved by the subject curve analysis. In addition, proper analysis carrying out was done in our work for some detailed assessments. The differential expression of ATGs is mainly related to chemotherapy resistance. Results A total of 9 ATGs of chemotherapy administration outcomes in these suffers were screened. Based on GEO and TCGA databases, the model accurately predicted DFS and OS after chemotherapy administration. Conclusions This study established prognostic markers based on 9 genes, predicting that ATGs are related to chemotherapy susceptibility of GC patients, which can provide better individualized treatment regimens for clinical practice.