bluuebunny/crossref_metadata_2025_split huggingface dataset:
A question of size and fear: competition and predation risk perception among frugivores and predators
Authors: Carreira Daiane Cristina , Brodie Jedediah F , Mendes Calebe P , Ferraz Katia Maria P M B , Galetti Mauro 
Published: March 2020

Abstract
Mammalian spatial and temporal activity patterns can vary depending on foraging behavior or the perception of predation or competition risk among species. These behaviors may in turn be altered by human influences such as defaunation. Herein, we evaluate whether frugivores avoid areas with high visitation rates by potential predators or competitors, and whether this avoidance changes in areas with different degrees of defaunation. We installed 189 cameras under fruit trees in six areas of the Atlantic Forest, Brazil, that differ in the abundance of top predators and large frugivores. Small predators and small frugivores were more frequent at night while large frugivores were more frequent during the day, but small frugivores visited and spent less time at fruiting trees on brighter nights, unlike large predators and large frugivores. Small frugivores also were less frequent in areas with high visitation by large frugivores and more frequent in highly defaunated areas. Our results suggest that the dynamics among mammalian functional groups varied according to diel patterns, potential competitors, and defaunation. We highlight the importance of understanding how species interactions are changing in areas exposed to strong human impacts to mitigate the indirect effects of defaunation.
Quantifying the interannual litterfall variations in China’s forest ecosystems
Authors: Jia Bingrui , Sun Hongru , Yu Wenying , Zhou Guangsheng 
Published: March 2020

Abstract

Aims
Litterfall is a key parameter in forest biogeochemical cycle and fire risk prediction. However, considerable uncertainty remains regarding the litterfall variations with forest ages. Quantifying the interannual variation of forest litterfall is crucial for reducing uncertainties in large-scale litterfall prediction.

Methods
Based on the available dataset (N = 318) with continuous multi-year (≥2 years) measurements of litterfall in Chinese planted and secondary forests, coefficient of variation (CV), variation percent (VP), and the ratio of next-year litterfall to current-year litterfall were used as the indexes to quantify the interannual variability in litterfall.

Important Findings
The interannual variations of litterfall showed a declining trend with increasing age from 1 to 90 years. The litterfall variations were the largest in 1–10 years (mean CV = 23.51% and mean VP = −28.59% to 20.89%), which were mainly from tree growth (mean ratio of next-year to current-year = 1.20). In 11–40 years, the interannual variations of litterfall gradually decreased but still varied widely, mean CV was ~18% and mean VP ranged from −17.69% to 21.19%. In 41–90 years, the interannual variations minimized to 8.98% in mean CV and ~8% in mean VP. As a result, forest litterfall remained relatively low and constant when stand age was larger than 40 years. This result was different from the previous assumptions that forest litterfall reached relatively stable when stand age was larger than 30, 20 or even 15 years. Our findings can improve the knowledge about forest litter ecology and provide the groundwork for carbon budget and biogeochemical cycle models at a large scale.
Formation of the polar debris disc around 99 Herculis
Authors: Smallwood Jeremy L , Franchini Alessia , Chen Cheng , Becerril Eric , Lubow Stephen H , Yang Chao-Chin , Martin Rebecca G 
Published: March 2020

ABSTRACT
We investigate the formation mechanism for the observed nearly polar aligned (perpendicular to the binary orbital plane) debris ring around the eccentric orbit binary 99 Herculis. An initially inclined non-polar debris ring or disc will not remain flat and will not evolve to a polar configuration, due to the effects of differential nodal precession that alter its flat structure. However, a gas disc with embedded well coupled solids around the eccentric binary may evolve to a polar configuration as a result of pressure forces that maintain the disc flatness and as a result of viscous dissipation that allows the disc to increase its tilt. Once the gas disc disperses, the debris disc is in a polar aligned state in which there is little precession. We use three-dimensional hydrodynamical simulations, linear theory, and particle dynamics to study the evolution of a misaligned circumbinary gas disc and explore the effects of the initial disc tilt, mass, and size. We find that for a wide range of parameter space, the polar alignment time-scale is shorter than the lifetime of the gas disc. Using the observed level of alignment of 3° from polar, we place an upper limit on the mass of the gas disc of about $0.014 \, \mathrm{M}_\odot$ at the time of gas dispersal. We conclude that the polar debris disc around 99 Her can be explained as the result of an initially moderately inclined gas disc with embedded solids. Such a disc may provide an environment for the formation of polar planets.
Do the solar flares originating from an individual active region follow a random process or a memory-dependent correlation?
Authors: Lei W H , Li C , Chen F , Zhong S J , Xu Z G , Chen P F 
Published: March 2020

ABSTRACT
We investigate the waiting time statistics of solar flares both in a flare-productive active region (AR 12673) of the solar cycle 24 and in a three-dimensional magnetohydrodynamic (MHD) simulated AR. The statistical models of a discrete random process and a continuous memory-dependent process are applied to interpret the waiting time distributions (WTDs) of solar flares. Our results indicate that the occurrence of a solar flare in an individual AR maintains a certain amount of memory, and probably arises from MHD turbulence rather than from intermittent avalanches in a self-organized criticality system. It differs from the occurrence of ‘super flares’ when treating the star/Sun as a single non-linear system.
An ALMA view of SO and SO2 around oxygen-rich AGB stars
Authors: Danilovich T , Richards A M S , Decin L , Van de Sande M , Gottlieb C A 
Published: March 2020

ABSTRACTWe present and analyse SO and SO2, recently observed with high angular resolution and sensitivity in a spectral line survey with ALMA, for two oxygen-rich AGB stars: the low mass-loss rate R Dor and high mass-loss rate IK Tau. We analyse 8 lines of SO detected towards both stars, 78 lines of SO2 detected towards R Dor, and 52 lines of SO2 detected towards IK Tau. We detect several lines of 34SO, 33SO, and 34SO2 towards both stars, and tentatively S18O towards R Dor, and hence derive isotopic ratios for these species. The spatially resolved observations show us that the two sulphur oxides are co-located towards R Dor and trace out the same wind structures in the circumstellar envelope. Much of the emission is well reproduced with a Gaussian abundance distribution spatially centred on the star. Emission from the higher energy levels of SO and SO2 towards R Dor provides evidence in support of a rotating inner region of gas identified in earlier work. The new observations allow us to refine the abundance distribution of SO in IK Tau derived from prior observations with single antennas, and confirm that the distribution is shell like with the peak in the fractional abundance not centred on the star. The confirmation of different types of SO abundance distributions will help fine-tune chemical models and allows for an additional method to discriminate between low and high mass-loss rates for oxygen-rich AGB stars.
Performance analysis of the Karhunen–Loève Transform for artificial and astrophysical transmissions: denoizing and detection
Authors: Trudu Matteo , Pilia Maura , Hellbourg Gregory , Pari Pierpaolo , Antonietti Nicolò , Maccone Claudio , Melis Andrea , Perrodin Delphine , Trois Alessio 
Published: March 2020

ABSTRACT
In this work, we propose a new method of computing the Karhunen–Loève Transform (KLT) applied to complex voltage data for the detection and noise level reduction in astronomical signals. We compared this method with the standard KLT techniques based on the Toeplitz correlation matrix and we conducted a performance analysis for the detection and extraction of astrophysical and artificial signals via Monte Carlo (MC) simulations. We applied our novel method to a real data study-case: the Voyager 1 telemetry signal. We evaluated the KLT performance in an astrophysical context: our technique provides a remarkable improvement in computation time and MC simulations show significant reconstruction results for signal-to-noise ratio (SNR) down to −10 dB and comparable results with standard signal detection techniques. The application to artificial signals, such as the Voyager 1 data, shows a notable gain in SNR after the KLT.
On the early evolution of massive star clusters: the case of cloud D1 and its embedded cluster in NGC 5253
Authors: Silich Sergiy , Tenorio-Tagle Guillermo , Martínez-González Sergio , Turner Jean 
Published: March 2020

ABSTRACT
We discuss a theoretical model for the early evolution of massive star clusters and confront it with the ALMA, radio, and infrared observations of the young stellar cluster highly obscured by the molecular cloud D1 in the nearby dwarf spheroidal galaxy NGC 5253. We show that a large turbulent pressure in the central zones of D1 cluster may cause individual wind-blown bubbles to reach pressure confinement before encountering their neighbours. In this case, stellar winds energy is added to the hot shocked wind pockets of gas around individual massive stars that leads them to meet and produce a cluster wind in time-scales less than 105 yr. In order to inhibit the possibility of cloud dispersal, or the early negative star formation feedback, one should account for mass loading that may come, for example, from pre-main-sequence (PMS) low-mass stars through photoevaporation of their protostellar discs. Mass loading at a rate in excess of 8 × 10−9 M⊙ yr−1 per each PMS star is required to extend the hidden star cluster phase in this particular cluster. In this regime, the parental cloud remains relatively unperturbed, while pockets of molecular, photoionized and hot gas coexist within the star-forming region. Nevertheless, the most likely scenario for cloud D1 and its embedded cluster is that the hot shocked winds around individual massive stars should merge at an age of a few million of years when the PMS star protostellar discs vanish and mass loading ceases that allows a cluster to form a global wind.
H–He collision-induced satellite in the Lyman α profile of DBA white dwarf stars
Authors: Allard Nicole F , Kielkopf John F , Xu Siyi , Guillon Grégoire , Mehnen Bilel , Linguerri Roberto , Al Mogren Muneerah Mogren , Hochlaf Majdi , Hubeny Ivan 
Published: March 2020

ABSTRACT
The spectra of helium-dominated white dwarf stars with hydrogen in their atmosphere present a distinctive broad feature centred around 1160 Å in the blue wing of the Lyman α line. It is extremely apparent in WD 1425+540 recently observed with Hubble Space Telescope(HST) Cosmic Origins Spectrograph (COS). With new theoretical line profiles based on ab initio atomic interaction potentials we show that this feature is a signature of a collision-induced satellite due to an asymptotically forbidden transition. This quasi-molecular spectral satellite is crucial to understanding the asymmetrical shape of Lyman α seen in this and other white dwarf spectra. Our previous work predicting this absorption feature was limited by molecular potentials that were not adequate to follow the atomic interactions with spectroscopic precision to the asymptotic limit of large separation. A new set of potential energy curves and electronic dipole transition moments for the lowest electronic states of the H–He system were developed to account accurately for the behaviour of the atomic interactions at all distances, from the chemical regime within 1 Å out to where the radiating H atoms are not significantly perturbed by their neighbours. We use a general unified theory of collision-broadened atomic spectral lines to describe a rigorous treatment of hydrogen Lyman α with these potentials and present a new study of its broadening by radiative collisions of hydrogen and neutral helium. These results enable ab initio modelling of radiative transport in DBA white dwarf atmospheres.
Agency as a Two-Way Power: A Defence
Authors: Steward Helen 
Published: March 2020

Abstract
This paper presents a dilemma which it has been alleged by Kim Frost must be faced by any defender of the notion of a two-way power and offers a solution to the dilemma which is distinct from Frost’s own. The dilemma is as follows: assuming that powers are to be individuated by what they are powers to do or undergo, then either there is a unified description of the manifestation-type which individuates the power, or there is not. If there is, then two-way powers are revealed really to be one-way powers, after all. If there is not, then it is difficult to explain why the two-way power does not simply dissolve into a mere combination of two one-way powers. The paper offers an account of what a two-way power is that is distinct from the one Frost takes for granted, and argues that this different conception is the key to avoiding the dilemma. It is also argued that this alternative conception has several further advantages over its rival and also that it has no less of a claim than Frost’s notion to be prefigured in Aristotle’s original discussion.
The genomic landscape of 8-oxodG reveals enrichment at specific inherently fragile promoters
Authors: Gorini Francesca , Scala Giovanni , Di Palo Giacomo , Dellino Gaetano Ivan , Cocozza Sergio , Pelicci Pier Giuseppe , Lania Luigi , Majello Barbara , Amente Stefano 
Published: March 2020

Abstract
8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is the most common marker of oxidative stress and its accumulation within the genome has been associated with major human health issues such as cancer, aging, cardiovascular and neurodegenerative diseases. The characterization of the different genomic sites where 8-oxodG accumulates and the mechanisms underlying its formation are still poorly understood. Using OxiDIP-seq, we recently derived the genome-wide distribution of 8-oxodG in human non-tumorigenic epithelial breast cells (MCF10A). Here, we identify a subset of human promoters that accumulate 8-oxodG under steady-state condition. 8-oxodG nucleotides co-localize with double strand breaks (DSBs) at bidirectional and CG skewed promoters and their density correlate with RNA Polymerase II co-occupancy and transcription. Furthermore, by performing OxiDIP-seq in quiescent (G0) cells, we found a strong reduction of oxidatively-generated damage in the majority of 8-oxodG-positive promoters in the absence of DNA replication. Overall, our results suggest that the accumulation of 8-oxodG at gene promoters occurs through DNA replication-dependent or -independent mechanisms, with a possible contribution to the formation of cancer-associated translocation events.
Preferential production of RNA rings by T4 RNA ligase 2 without any splint through rational design of precursor strand
Authors: Chen Hui , Cheng Kai , Liu Xiaoli , An Ran , Komiyama Makoto , Liang Xingguo 
Published: March 2020

Abstract
Rings of single-stranded RNA are promising for many practical applications, but the methods to prepare them in preparative scale have never been established. Previously, RNA circularization was achieved by T4 RNA ligase 2 (Rnl2, a dsRNA ligase) using splints, but the yield was low due to concurrent intermolecular polymerization. Here, various functional RNAs (siRNA, miRNA, ribozyme, etc.) are dominantly converted by Rnl2 to the rings without significant limitations in sizes and sequences. The key is to design a precursor RNA, which is highly activated for the efficient circularization without any splint. First, secondary structure of target RNA ring is simulated by Mfold, and then hypothetically cut at one site so that a few intramolecular base pairs are formed at the terminal. Simply by treating this RNA with Rnl2, the target ring was selectively and efficiently produced. Unexpectedly, circular RNA can be obtained in high yield (&gt;90%), even when only 2 bp form in the 3′-OH side and no full match base pair forms in the 5′-phosphate side. Formation of polymeric by-products was further suppressed by diluting conventional Rnl2 buffer to abnormally low concentrations. Even at high-RNA concentrations (e.g. 50 μM), enormously high selectivity (&gt;95%) was accomplished.
A GoldenBraid cloning system for synthetic biology in social amoebae
Authors: Kundert Peter , Sarrion-Perdigones Alejandro , Gonzalez Yezabel , Katoh-Kurasawa Mariko , Hirose Shigenori , Lehmann Peter , Venken Koen J T , Shaulsky Gad 
Published: March 2020

Abstract
GoldenBraid is a rapid, modular, and robust cloning system used to assemble and combine genetic elements. Dictyostelium amoebae represent an intriguing synthetic biological chassis with tractable applications in development, chemotaxis, bacteria–host interactions, and allorecognition. We present GoldenBraid as a synthetic biological framework for Dictyostelium, including a library of 250 DNA parts and assemblies and a proof-of-concept strain that illustrates cAMP-chemotaxis with four fluorescent reporters coded by one plasmid.
Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, for treatment of anemia of chronic kidney disease: two randomized Phase 2 trials in Japanese patients
Authors: Nangaku Masaomi , Farag Youssef M K , deGoma Emil , Luo Wenli , Vargo Dennis , Khawaja Zeeshan 
Published: March 2020

Abstract

Background
Vadadustat is an investigational, oral hypoxia-inducible factor prolyl hydroxylase inhibitor in development in Japan for the treatment of chronic kidney disease (CKD)-induced anemia.

Methods
Two Phase 2, multicenter, double-blind, placebo-controlled studies randomized Japanese patients with nondialysis-dependent (NDD, n = 51) or dialysis-dependent (DD, n = 60) CKD-induced anemia to once-daily vadadustat (150, 300 or 600 mg) or placebo. A 6-week, fixed-dose primary efficacy period was followed by a 10-week vadadustat dose adjustment/maintenance period. The primary endpoint was the mean change in hemoglobin (Hb) level from pretreatment to Week 6.

Results
Statistically significant (P &lt; 0.01) dose-dependent increases in mean Hb values were observed at Week 6 in all vadadustat groups versus placebo [placebo and vadadustat 150, 300 and 600 mg: −0.47, 0.43, 1.13 and 1.62 (NDD-CKD) and −1.48, −0.28, 0.08 and 0.41 (DD-CKD), respectively]. By Week 16, 91% (NDD-CKD) and 71% (DD-CKD) of vadadustat-treated participants achieved target Hb levels (10.0–12.0 g/dL) and significant dose-dependent changes in iron utilization and mobilization biomarkers were observed with vadadustat. During the primary efficacy period, the incidence of treatment-emergent adverse events (AEs) with placebo and vadadustat 150, 300 and 600 mg was 36, 33, 58 and 54% (NDD-CKD) and 40, 53, 73 and 40% (DD-CKD), respectively. The most common AEs during the primary efficacy period were nausea and hypertension (NDD-CKD) and diarrhea, nasopharyngitis and shunt stenosis (DD-CKD). Of 23 serious AEs in 18 patients, 1 was deemed related (hepatic function abnormal); no deaths were reported.

Conclusions
The efficacy and safety results from these studies support the development of vadadustat for the treatment of anemia in patients with CKD.
A Group of O-Acetyltransferases Catalyze Xyloglucan Backbone Acetylation and Can Alter Xyloglucan Xylosylation Pattern and Plant Growth When Expressed in Arabidopsis
Authors: Zhong Ruiqin , Cui Dongtao , Phillips Dennis R , Richardson Elizabeth A , Ye Zheng-Hua 
Published: March 2020

Abstract
Xyloglucan is a major hemicellulose in plant cell walls and exists in two distinct types, XXXG and XXGG. While the XXXG-type xyloglucan from dicot species only contains O-acetyl groups on side-chain galactose (Gal) residues, the XXGG-type xyloglucan from Poaceae (grasses) and Solanaceae bears O-acetyl groups on backbone glucosyl (Glc) residues. Although O-acetyltransferases responsible for xyloglucan Gal acetylation have been characterized, the biochemical mechanism underlying xyloglucan backbone acetylation remains to be elucidated. In this study, we showed that recombinant proteins of a group of DUF231 members from rice and tomato were capable of transferring acetyl groups onto O-6 of Glc residues in cello-oligomer acceptors, indicating that they are xyloglucan backbone 6-O-acetyltransferases (XyBATs). We further demonstrated that XyBAT-acetylated cellohexaose oligomers could be readily xylosylated by AtXXT1 (Arabidopsis xyloglucan xylosyltransferase 1) to generate acetylated, xylosylated cello-oligomers, whereas AtXXT1-xylosylated cellohexaose oligomers were much less effectively acetylated by XyBATs. Heterologous expression of a rice XyBAT in Arabidopsis led to a severe reduction in cell expansion and plant growth and a drastic alteration in xyloglucan xylosylation pattern with the formation of acetylated XXGG-type units, including XGG, XGGG, XXGG, XXGG,XXGGG and XXGGG (G denotes acetylated Glc). In addition, recombinant proteins of two Arabidopsis XyBAT homologs also exhibited O-acetyltransferase activity toward cellohexaose, suggesting their possible role in mediating xyloglucan backbone acetylation in vivo. Our findings provide new insights into the biochemical mechanism underlying xyloglucan backbone acetylation and indicate the importance of maintaining the regular xyloglucan xylosylation pattern in cell wall function.
What Constitutes Sufficient Evidence for Case Formulation–Driven CBT for Psychosis? Cumulative Meta-analysis of the Effect on Hallucinations and Delusions
Authors: Turner David T , Burger Simone , Smit Filip , Valmaggia Lucia R , van der Gaag Mark 
Published: March 2020

Abstract

Objective
Following 2 decades of research on cognitive behavioral therapy for psychosis (CBTp), it is relevant to consider at which point the evidence base is considered sufficient. We completed a cumulative meta-analysis to assess the sufficiency and stability of the evidence base for hallucinations and delusions.

Method
We updated the systematic search from our previous meta-analytic review from August 2013 until December 2019. We identified 20 new randomized controlled trials (RCTs) resulting in inclusion of 35 RCTs comparing CBTp with treatment-as-usual (TAU) or active controls (AC). We analyzed data from participants with psychosis (N = 2407) over 75 conventional meta-analytic comparisons. We completed cumulative meta-analyses (including fail-safe ratios) for key comparisons. Publication bias, heterogeneity, and risk of bias were examined.

Results
Cumulative meta-analyses demonstrated sufficiency and stability of evidence for hallucinations and delusions. The fail-safe ratio demonstrated that the evidence base was sufficient in 2016 for hallucinations and 2015 for delusions. In conventional meta-analyses, CBTp was superior for hallucinations (g = 0.34, P &lt; .01) and delusions (g = 0.37, P &lt; .01) when compared with any control. Compared with TAU, CBTp demonstrated superiority for hallucinations (g = 0.34, P &lt; .01) and delusions (g = 0.37, P &lt; .01). Compared with AC, CBT was superior for hallucinations (g = 0.34, P &lt; .01), but not for delusions although this comparison was underpowered. Sensitivity analyses for case formulation, primary outcome focus, and risk of bias demonstrated increases in effect magnitude for hallucinations.

Conclusions
The evidence base for the effect of CBTp on hallucinations and delusions demonstrates sufficiency and stability across comparisons, suggesting limited value of new trials evaluating generic CBTp.