bluuebunny/crossref_metadata_2025_split huggingface dataset:
El abordaje temprano y tratamiento mixto en el manejo de la esquizofrenia
Authors: Vílchez Salcedo Luis Arturo , Turco Arévalo Elena , Varillas Marín Rudy Ángel , Salgado Valenzuela Carlos Alexis , Salazar de la Cruz Miriam , Carmona Clavijo Gloria , Huamán Sánchez Karen , Bonilla Untiveros Catherine , Reyes Puma Nora , Caballero Ñopo Patricia 
Published: December 2019

Introducción: La esquizofrenia es un trastorno psicótico caracterizado por alteración sustantiva del funcionamiento mental y efectos sobre la funcionalidad social de la persona afectada. Objetivo: Brindar recomendaciones basadas en la mejor evidencia disponible para abordaje temprano, tratamiento farmacológico y psicosocial. Métodos: Se elaboró una guía de práctica clínica basada en evidencias (GPC-BE), adaptada mediante proceso sistemático, riguroso, transparente, desarrollado por un grupo elaborador integrado por metodólogos y psiquiatras expertos en el manejo de esquizofrenia. La guía comprende cuatro preguntas clínicas y recomendaciones, se realizó búsqueda de guías que respondan al tema priorizado, se preseleccionaron y evaluaron guías mediante el instrumento “Appraisal of Guidelines for Research and Evaluation II” (AGREE-II), la de mejor calidad metodológica fue elegida para adaptación. La búsqueda sistemática de evidencias para cada pregunta clínica fue realizada en múltiples bases de datos: MEDLINE/Ovid, EMBASE/Ovid, EMB reviews/Ovid. La selección y análisis de evidencias se realizó mediante pares clínicos y metodológos, las recomendaciones fueron elaboradas aplicando metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Resultados: Con participación del panel de expertos clínicos de institutos y hospitales del Perú referentes en el manejo de esquizofrenia, se elaboraron cuatro recomendaciones para la intervención temprana, tratamiento farmacológico y mixto de pacientes adultos con esquizofrenia. Conclusiones: Se recomienda el abordaje temprano del primer episodio psicótico a través de centros de salud mental comunitarios (CSMC) y hospitales especializados y tratamiento farmacológico junto a terapia psicosocial estandarizada. El presente artículo resume la guía de práctica clínica basada en evidencias elaborada por un hospital público peruano especializado en salud mental.
Discrete Multistage Optimization and Hierarchical Market
Authors: Bistrickas V. J. , Šimelienė N. 
Published: December 2019

New simple form of mixed solutions is described by bilinear continuous optimization processes. It enables investigate an analytic solutions and the connection between discrete and continuous optimization processes. Connection between discrete and continuous processes is stochastic. Discrete optimization processes are used for the control works in levels and groups of the hierarchical market. Equilibrium between local and global levels of works is investigated in hierarchical market.
Kia Tae Pākoro: Lessons of CEAD 2018
Authors: Gray-Sharp Katarina 
Published: December 2019

When Camilo Catrillanca (24) died, he had one son and a pregnant wife. He was a weichafe (warrior) of the Mapuche, one of nine indigenous nations recognised in the Chilean Census. I learnt of Camilo’s life and death as a consequence of my attendance at the 2018 hui of Contemporary Ethnography Across the Disciplines (CEAD). I was able to learn about Camilo because I arrived at the hui laden with, aware of, and willing to share my own sorrow (tae pākoro).
This article stories the environment within which the CEAD hui 2018 was held. It discusses the history of settler colonialism in Chile, the problems of Via Chile.a and the suffering of La Araucan.a. The writing reflects my time as a manuhiri in Santiago. It recognises my autoethnographic method’s whakapapa as offspring to a tool of colonisation. Hence, it offers a different form of autoethnography, one that begins with the tangata whenua, the people of the earth.
İslam Bahçeleri’nde Ayet ve Hadislerden Esintiler
Authors: SEVEN Nagehan , AKTEN Murat 
Published: December 2019

Cennet ayet ve hadislerde sıkça bahsedilen konular arasında yer almaktadır. İslam da cennet salih amel işleyen müminlere ahirette verilecek olan en büyük mükâfatlar arasında yer almaktadır. Ancak bu çalışmada cennetin, bu yönü değil, içerisinde bulunan unsurlar ve genel yapısının İslam Bahçeleri'ndeki tesiri incelenmiştir. İslam Bahçesi, sert zeminlerden oluşan yürüme yolları, geometrik su kanalları, yeşilliklerin yer aldığı ve etrafı sağır duvarlarla çevrili bir yapıya sahiptir. İslam Bahçesi'nin genellikle sahip olduğu bu karakteristik özellikler çalışmamızın ana konularıdır. İslam Bahçesi'nde ortaya çıkan bu özelliklerde ayet ve hadislerde bahsedilen cennet olgusunun nasıl ve ne derecede etkili olduğu da araştırmamızın diğer bir yönüdür. Makalede İslam Bahçesi'nin karakteristik özellikleri ile ayet ve hadislerde geçen cennetin unsurları karşılaştırılmıştır. Böylece benzer ve farklı yönleri ortaya konulup tartışılmıştır. İslam Bahçelerine genel itibariyle bakıldığında cennetin, insanlar tarafından beşeri olarak yorumlandığı ve bunun sonucu olarak da İslam Bahçelerine yapısal, bitkisel ve suyun kullanım biçiminde önemli bir tesiri olduğu anlaşılmaktadır.
TÜRKİYE GÖRME ENGELLİLER YÜZME ŞAMPİYONASINA KATILAN SPORCULARIN SPORA ÖZGÜ BAŞARI MOTİVASYON DÜZEYLERİNİN İNCELENMESİ
Authors: YILMAZ Atike , KIRIMOĞLU Hüseyin , KAYNAK Kerimhan 
Published: December 2019

Bu araştırma
Türkiye Görme Engelliler Yüzme Şampiyonasına katılan, görme engelli
sporcuların, spora özgü başarı motivasyon düzeylerinin çeşitli değişkenler
açısından incelenmesine odaklanmıştır. Katılımcıların spora özgü başarı
motivasyonlarının belirlenmesinde, araştırmacılar tarafından geliştirilen
“Kişisel Bilgi Formu” ile Wills tarafından geliştirilen ve Türkçe’ye uyarlaması
1997 yılında Tiryaki ve Gödelek tarafından yapılan “Spora Özgü Başarı
Motivasyonu” ölçeği kullanılmıştır. Araştırmanın evrenini, Türkiye Görme
Engelliler Federasyonu tarafından 2017 yılında, Alanya ilinde gerçekleştirilen Türkiye
Görme Engelliler Yüzme Şampiyonası’na katılan, toplamda 94 (35 kadın, 59 erkek)
görme engelli sporcu oluşturmaktadır. Örneklem grubunu ise, çalışmamıza gönüllü
katılan, toplamda 74 (27 kadın, 47 erkek) sporcu oluşturmuştur. Araştırmanın verileri SPSS 22.0 istatistik
programında analiz edilmiştir. Normallik sınaması testine göre; Sporda başarı
motivasyon ölçeği toplam puan, başarıya yaklaşma ve güç gösterme güdüsü alt
boyutu toplam puanı normal dağılım göstermiştir (p&gt;0,005), başarısızlıktan
kaçma alt boyutu toplam puanı ise, normal dağılım göstermemiştir (p&lt;0,005).
Bu nedenle normal dağılım gösteren verilere Anova, normal dağılım göstermeyen
verilere Mann Whitney U ve Kruskal Wallis testleri uygulanmıştır. Elde edilen
bulgularda katılımcıların, spora özgü başarı motivasyon düzeylerinin, cinsiyet,
eğitim durumu, algılanan gelir, yaş ve engelin oluşum zamanı değişkenleri
açısından anlamlı düzeyde farklılaşmadığı, buna karşın, başarıya yaklaşma güdüsü düzeyi ile yaş
gruplarının birbirleri arasında anlamlı düzeyde farklılık tespit edilmiştir.
Elde edilen farklılığa göre, 11-15 yaş aralığında bulunan katılımcıların 16-20
yaş katılımcılara, 16-20 yaş aralığında bulunan katılımcıların ise 21-25 ve 25
yaş üstü katılımcılara oranla daha yüksek başarıya yaklaşma güdüsüne sahip
oldukları tespit edilmiştir. Sonuç olarak katılımcılar açısından, spora özgü başarı motivasyon
düzeyleri ile araştırma değişkenleri arasında anlamlı farklılık bulunamazken,
16-20 yaş arasındaki katılımcıların başarıya yaklaşma güdüsünün yüksek olduğu
söylenebilir.
Problem Çözme Becerileri Eğitim Programının Çocukların Karar Verme Becerileri Üzerindeki Etkisi
Authors: PEKDOĞAN Serpil 
Published: December 2019

Bu çalışmanın amacı Problem Çözme Becerileri Eğitim Programının okul öncesi eğitime devam eden 5-6 yaş çocukların karar verme becerilerine etkisini incelemektir. Araştırmada öntest-sontest-kalıcılık testi kontrol gruplu deneysel desen kullanılmıştır. Çalışmaya anaokuluna devam eden 5-6 yaş grubunda 50 çocuk (25 deney, 25 kontrol) katılmıştır. Uygulama sürecinin ilk aşamasında deney ve kontrol grubundaki çocuklara ön test uygulaması yapılmıştır. Daha sonra deney grubundaki çocuklara 5 hafta boyunca haftada 2 kez Problem Çözme Becerileri Eğitim Programı uygulanmıştır. Araştırmanın verileri araştırmacı tarafından geliştirilen Karar Verme Becerileri Değerlendirme Aracı-Çocuk Formu ile toplanmıştır. Verilerin analizinde ön test puanlarının karşılaştırılmasında bağlı örneklemler t testi ve ön test-son test ve kalıcılık testi karşılaştırmalarında ise tekrarlı ölçümler için ANOVA kullanılmıştır. Çalışmanın sonucunda deney ve kontrol grubundaki çocukların karar verme becerileri puanları arasında anlamlı farklılık olduğu (p&lt;0,05) bulunmuştur. Eğitim programının kalıcılığına ilişkin yapılan kalıcılık testi sonucunda, eğitim programının etkisinin devam ettiği saptanmıştır (p&gt;,05). Bu bulgular ışığında çocukların karar verme becerilerini geliştirmek için araştırmacı ve eğitimcilere bazı önerilerde bulunulmuştur.
Library renovation
Authors: Wells Elaine 
Published: December 2019

The journey started at a 2016 meeting of the college’s Learning Resources Committee, which I chair as Library Director, A student representative casually commented that our Library looked “dated”. Not that we actually WERE dated, we have electronic resources, 24/7 remote access, printers, scanners, wireless, and a state-of-the-art Library Management System. However, through the eyes of our young student, the Library looked “like something from the 1970s.” Anyone who has lived through that decade’s will know that was not meant as a compliment. The student’s criticism prompted the Dean of Academic Affairs, who sat in on the meeting, to ask when the Library had had its last “facelift.” That was an easy one to answer - as far as I knew…never. And I’ve been here over 20 years.
Just like that, a renovation was born. How hard could this be? I would query the students on what a suitable update might look like, get a budget, buy some new furniture, and go back to the business of being a librarian rather than an interior designer. Spoiler alert: not so fast.
A study of status of contralateral ear in unilateral chronic otitis media in 500 patients
Authors: Jambunathan Prabaakharan , Maan Arvinder S. , Sharma Karan 
Published: December 2019

<p class="abstract"><strong>Background:</strong> The aim of this study was to examine the contralateral ear clinically, audiologically and radiologically and compare the findings with squamous and mucosal type of chronic otitis media (COM).</p><p class="abstract"><strong>Methods:</strong> A cross sectional study conducted in patients attending ENT Department, Government Medical College, Amritsar between December 2016 to November 2018. The study was conducted in 500 patients of either sex aged between 8 to 60 years with unilateral COM without perforation or history of ear discharge in the contralateral ear. Otoscopy, pure tone audiometry and X-ray mastoid or high-resolution computed tomography temporal bone were done on the patients. The results were recorded and analysed with SPSS software. </p><p class="abstract"><strong>Results:</strong> 82% patients were found to have some abnormalities in the contralateral ear. On otoscopy abnormalities in contralateral ear includes retraction of tympanic membrane, thinning and tympanosclerotic patch, most common abnormality being retraction of tympanic membrane. Radiological analysis of contralateral mastoids showed 39% diploic and 22.8% sclerotic mastoids. Hearing status in the contralateral ear showed 45.6% patient with normal hearing, 48.6% with conductive hearing loss and 5.8% with mixed hearing loss. 40.4% contralateral ears had mild, 12% had moderate and 2% had severe hearing loss.</p><p class="abstract"><strong>Conclusions:</strong> Contralateral ear pathologies were more in those who had squamosal type of COM than who had mucosal type in the diseased ear. The contralateral ear shows unmistakable predilection towards developing COM in the future.</p><p class="abstract"> </p><p> </p>
Influence of historical & social events on knowledge & knowledge production: A focus on some selected social theorists
Authors: Maigari Abdullahi Muhammad , Arafat Ibrahim 
Published: December 2019

This article examines the relationship between knowledge produced by social theorists and the social events that occurred before and during their lifetime. The aim of the paper is to identify the social events and how they shaped the thoughts and knowledge produced by the selected theorists. This was approached through a review of secondary literature and narrative style to analyse the sourced materials. The paper examined three social theorists, philosophers or thinkers: Ibn Khaldun, Hegel and Comte. The study found that the knowledge produced by these theorists have traversed beyond disciplines classified as social sciences. It shows that the knowledge produced is intertwined with what happened before and during the time they lived which is reflected in their intellectual works. The paper submits that knowledge cannot be separated from the social reality of its producer. Therefore, the paper concludes that social theorists examined thought and wrote based on the social realities they encountered.
Keywords: Historical event, influence, social theorists, knowledge production.
UJI EFEKTIFITAS AGENSIA HAYATI DALAM MENGENDALIKAN PENYAKIT LAYU BAKTERI Ralstonia solanacearum DAN MENINGKATKAN PERTUMBUHAN SERTA HASIL TANAMAN CABAI (Capsicum annum)
Authors: Kasidal Kasidal , Aidawati Noor , Adriani Dewi Erika 
Published: December 2019

Chili is an important commodity for most people, because of its function in terms of improving taste and appetite. Chili was seriously developed with the support of government funds for chili farmers. The development of chili plants, has enough obstacles, especially wich caused by plant disturbing organisms whether it is pests or diseases. The important organism that disturbs chili is wilting caused by Ralstonia solanacearum. In South Kalimantan, this disease reportedly attacked chilies spread in the districts of Banjar, Banjarbaru, Barito Kuala, Tapin, Hulu Sungai Tengah and Balangan with a cumulative attack area of 15,7 ha on 2017 (South Kalimantan BPTPH Database). This disease is important because of the nature of the attack which can cause the plants to wilt suddenly all part of the plant. Plants wich attacked by bacterial wilt cannot be cured. The effort that can be done in prevention before pathogens infect the plants (Sastra, 2004). One way to overcome this problem is biological control using biological agents from the type of antagonistic bacteria Bacillus spp, Pseudomonas fluorescens, and type of antagonistic fungus Trichoderma spp. From three biological agents proven able to inhibit the development of R. solanacearum in vitro which produces a zone of inhibition as wide as 13,5 mm for Bacillus spp, 22,25 mm for Pseudomonas fluorescens and 8,42 mm for Trichoderma spp. and can increase plant height growth, chili weight, root weight, wet weight, and dry weight plants. Trichoderma spp as the best biological agents for increasing chili growth and yield.
Silencing of Long non-coding RNA Plasmacytoma variant translocation 1 inhibits the proliferation, migration, invasion and fibrosis of high glucose-induced mouse mesangial cells via targeting microRNA-93-5p
Authors: Li Jianzhou , Zhao Qing , Jin Xiaohong , Li Yanhua , Song Jian 
Published: December 2019

Abstract
Background: This study aimed to investigate the regulatory role of Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) on the biological processes of high glucose (HG)-induced mouse mesangial cells (MMCs). Methods: PVT1 expression in diabetic nephropathy (DN) mice and HG-induced MMCs was detected by qRT-PCR. PVT1 was silenced in HG-induced MMCs by the transfection of PVT1 siRNA (si-PVT1). EdU and Colony formation, Annexin V-PI staining, Muse cell cycle, Scratch, and Transwell assay were performed to detect the cell proliferation, apoptosis, cell cycle, migration, and invasion, respectively. The contents of fibrosis factors in cell-culture supernatants were detected by ELISA. Western blot was performed to detect the expression of factors involved in apoptosis, cell cycle, migration and invasion, fibrosis, and PI3K/Akt/mTOR pathway. In addition, the targeting relation between miR-93-5p and PVT1 was predicted by StarBase3.0 and identified by Dual-luciferase reporter gene assay. Results: PVT1 was overexpressed in DN kidney tissues and HG-induced MMCs. HG-induced MMCs exhibited significantly increased EdU positive cells, cell colonies, S and G2/M phase cells, migration and invasion ability, and contents of fibrosis factors, as well as significantly decreased apoptosis rate compared with NG-induced MMCs. HG significantly up-regulated Bcl-2, CyclinD1, CDK4, N-cadherin, vimentin, Col. IV, FN, TGF-β1 and PAI-1, and down-regulated Bax, cleaved caspase-3, cleaved PARP, and E-cadherin in MMCs. Silencing of PVT1 eliminated the effects of HG in MMCs and blocked PI3K/Akt/mTOR pathway. MiR-93-5p was a target of PVT1, which eliminated the effects of PVT1 on HG-induced MMCs. Conclusions: PVT1 silencing inhibited the proliferation, migration, invasion and fibrosis, promoted the apoptosis, and blocked PI3K/Akt/mTOR pathway in HG-induced MMCs via up-regulating miR-93-5p.
Evaluating the Bystander Effects of Electron Beam Irradiation in Radiotherapy on MCF-7 Human Breast Cancer Cells
Authors: Feghhi Maryam , Rezaie Jafar , Mostafanezhad Kamal , Jabbari Nasrollah 
Published: December 2019

Abstract
Background: The distinct direct and non-targeting effects of electron beam radiation on MCF-7 cells remain unclear. We aimed to investigate the effect of electron beam radiation and conditioned media of the irradiated MCF-7 cells on MCF-7 cells.Methods: The cell viability and apoptosis were assayed via MTT and flow cytometry analysis, respectively. Production of oxygen reactive species was evaluated by chemical fluorometric method, while the amount of extracellular vesicles was detected via acetylcholinesterase activity assay. Change in the expression of genes involved in apoptosis including caspase-3, caspase-8, and caspase-9 and stemness such as Sox-2 and Oct-4 were calculated through qPCR. Wound healing rate of cells was monitored via in vitro scratch assy. Results: Result showed that compared to control group, electron beam radiation decreased cell viability and increased apoptosis and oxygen reactive species as well as acetylcholinesterase activity in a dose-dependent manner (P<0.05). Concurrent with increasing dose of electron beam, the mRNA level of apoptotic genes (caspase-3, caspase-8, and caspase-9) and stemness related genes (Sox-2 and Oct-4) up-regulated following electron beam radiation. Wound healing rate of irradiated MCF-7 cells dose-dependently increased (P<0.05). After treatment with conditioned media from irradiated MCF-7 cells, the similar results were observed. Conditioned media from irradiated MCF-7 cells decreased viability of MCF-7 cells, mesenchymal stem cells, and HUVECs (P<0.05). Additionally, conditioned media from irradiated MCF-7 cells promoted apoptosis and wound healing rate as well as increased mRNA levels of apoptosis and stemness related genes (P<0.05). Conclusion: Findings suggest electron beam radiation could affect apoptosis and stemness in MCF-7 cells in direct and bystander manners.
Exploration of workplace violence among nurses at a selected University Teaching Hospital in Rwanda
Authors: Banamwana Gilbert 
Published: December 2019

Abstract
Background: Workplace violence is a global problem in the health sector especially in the hospitals affecting healthcare works' job satisfaction and performance. Method: The research approach used was quantitative descriptive cross-sectional design. The stratified random sampling method was used to recruit 195 participants among 379 nurses. Results: The findings revealed that 58.5 % (n=114) of nurses have experienced some types of workplace violence in the twelve months preceding the study among them 44.6% (=108) of nurses were verbally abused. Conclusion: Based on the study findings, it was concluded that the hospital management needs to be aware of workplace violence, develop and implement appropriate policies and strategies. These strategies will strengthen nurses' concentration towards their and will results in service delivery improvement. Keywords: Workplace, workplace violence, nurses
Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China
Authors: Wu Heming , Wu Hailing , Yu Zhikang , Zhu Qiuyan , Zhang Qunji , Huang Qingyan , Zhong Zhixiong 
Published: December 2019

Abstract
Background APOE and SLCO1B1 genetic polymorphisms are relevant in statin pharmacokinetics.Objective Aim of this study was to investigate the polymorphisms of APOE and SLCO1B1 gene in Meizhou area.Methods Genotying of APOE and SLCO1B1 genetic polymorphisms were conducted in 4761 individuals.Results Among two variants of SLCO1B1 in Meizhou, the frequencies of 388A>G and 521T>C allele were 74.89% and 11.54% separately. The frequency of SLCO1B1 gene hplotype *1b/*1b was 40.37% followed by *1a/*1b (31.93%) and *1b/*15(14.14%). There were no significant differences between men and women in this study except SLCO1B1 521T>C ( SLCO1B1 521TT, P =0.019; SLCO1B1 521TC, P =0.028) and haplotypes *1a/*15 of SLCO1B1 (*1a/*15, P=0.02). Moreover, the frequencies of APOE ɛ3/ɛ3 was 69.94%, followed by 15.77% in ɛ3/ɛ4, 11.30% in ɛ2/ɛ3, 1.56% in ɛ2/ɛ4, 1.02% in ɛ4/ɛ4 and 0.54% in ɛ2/ɛ2, with considerably higher rate of allele ɛ3 (83.48%).Conclusions The population of Meizhou has different distribution feature. This study provides a reference to optimize the individualization of drug use in this area.
Burnout Syndrome on Teachers and its Relation to Nutrition: An Integrative Review
Authors: Neves Iza Carneiro , Amorim Fábio Ferreira , Ribeiro Salomon Ana Lúcia 
Published: December 2019

Background:
Teaching is considered as one of the most stressful professions that can
lead to repercussions on physical and mental health, as well as on professional performance. Among
the most common psychiatric conditions in teachers, there is Burnout Syndrome (BS) that is considered
a disease of physical and mental exhaustion. One of the measures to mitigate this condition is
to change eating habits, seeking an improvement in the quality of life and mental health. Therefore,
the objective of this integrative review was to evaluate the relationship between the promotion of
healthy eating habits and BS in teachers.

Methods:
A comprehensive literature search was conducted to include articles published using
Medline / Pubmed, Lilacs / Bireme and Google Scholar, and the descriptors: burnout syndrome,
nutrition and food education, depression and quality of life, teacher, and mental health, with an
emphasis in the last ten years.

Results:
Thirty-seven studies were included. These studies suggest that approaches on health nutrition
habits may improve BS and mental health. Furthermore, deficient intake of magnesium, zinc,
vitamins D, C, E and of the B complex, tryptophan, calcium, iron, omega 3, probiotics, and polyphenols
may contribute to arousal or worsening of BS symptoms. However, no experimental studies
that evaluated the association between eating patterns and BS in teachers were found.

Conclusion:
Although there were no experimental studies on teachers, other studies suggested a
positive association between healthy nutrition habits and improvement of mental health and BS
prevention and/or treatment. The behavioral approach to change eating habits can contribute to more
effective outcomes.