bluuebunny/crossref_metadata_2025_split huggingface dataset:
Politics of Engagement: Gender Expertise and International Governance
Authors: Altan‐Olcay Özlem 
Published: July 2020

ABSTRACTThis article studies the experiences of gender experts in international institutions of governance and examines their interactions with multiple actors in the governance system as they negotiate their authority to act as experts. Moving beyond binaries, such as those on the inside of hegemonic institutions versus those on the outside, or co‐optation versus activism, the analysis uses processes of instrumentalization as a vantage point to lay out the multiple paths emerging in these politics of engagement. The article frames politics of engagement in terms of micropolitical tensions, ambivalences and contradictions that unfold in these interactions. It first argues that the boundaries that exist between inside and outside institutions are not clear cut because actors circulate between them. The study shows how gender experts instrumentalize their own life and career trajectories, navigating between advocacy and governance, to enhance their power in current institutional settings. It then focuses on instrumentalist discourses and traces their emergence in unequal negotiations. It demonstrates how gender experts can become part of the processes that they also critique. Finally, the study analyses strategies in which experts instrumentalize institutional inequalities to their advantage to produce diverse political possibilities with open‐ended outcomes.
Predator pheromone elicits a temporally dependent non‐consumptive effect in prey
Authors: Aflitto Nicholas C. , Thaler Jennifer S. 
Published: July 2020

The influence of predator cues on the behaviour of prey is well supported in the literature; however, a clear understanding of how predator cues affect prey in variable environmental conditions and over longer time scales is needed to better understand the underlying mechanisms. Here, we measure how predator odors affect herbivore colonization, abundance, oviposition, and plant damage across two growing seasons.
The study system consisted of Leptinotarsa decemlineata (Colorado potato beetle) as prey, and the aggregation pheromone of live Podisus maculiventris (spined soldier bug) as the predator cue in a potato field.
In 2016, the amount of feeding damage by early beetle colonists was lower in predator odor‐treated plots, reducing plant damage by 22%. Larval abundance was also reduced in treated plots in 2016. Beetle abundance and damage in 2017 was similar in the treatment and control plots. Two mechanisms were investigated to better understand why prey response to the predator odor treatment weakened over the first season, including changes in predator odor cue strength and prey habituation. Predator odor cue strength emerged as a likely explanation, as dispensers, which released a synthetic predator pheromone over the entire season, reduced the probability of finding damage more consistently than the live predator treatment.
These results suggest that temporal patterns of predator cue release and strength may drive prey response across the season, underscoring the importance of cue release‐rate and consistency in both species interactions and for the future application of modifying insect behaviour using non‐consumptive effects in agricultural systems.
Retyping of triple‐negative breast cancer based on clustering method
Authors: Liu Bo , Li Xingrui , Wang Huina , Zhao Shuangtao , Li Jianqiang , Qu Guangzhi , Wang Fei 
Published: July 2020

AbstractTriple‐negative breast cancer is the worst prognosis in breast cancer, accounting for 10.0–20.8% of all breast cancers. Considering that triple‐negative breast cancer has great heterogeneity and very poor prognosis, clinical medication guidance is in urgent need of a more detailed classification of breast cancer itself. Although many researchers have been dedicated to the clustering of triple‐negative breast cancer and have found possible targets based on typing, their results are not closely related to the prognosis. This paper utilizes three clustering methods to retype the patient data with triple‐negative breast cancer, and the results show that the triple‐negative breast cancer data could be classified into two categories. Eight important genes and three important clinical factors related to the prognosis of two types of triple‐negative breast cancer have been obtained. These genes have the following three characteristics: co‐expression, differential expression and interaction. In terms of breast cancer control, the prognosis can be controlled as much as possible by regulating gene levels, which provides new directions and ideas for related research on breast cancer prognosis.
Collective bargaining towards mutual flexibility and security goals in large internationalised companies—why do institutions (still) matter?
Authors: Paolucci Valentina , Marginson Paul 
Published: July 2020

AbstractThis paper examines the potential of collective bargaining to generate mutually advantageous flexibility and security outcomes at firm level. By focusing attention on actors' negotiating capacity at sites in Denmark and Italy of four large chemical‐pharmaceutical companies, it provides a nuanced, comparative explanation. The findings demonstrate that, across countries, differences in actors' capacity and negotiated outcomes are attributable to the stability and depth of collective bargaining institutions. Within country differences are accounted for by the organisational resources (internal democracy, external links and pro‐activity) of local trade unions, which condition their capacity to induce management to negotiate outcomes which benefit both parties.
Lesion characteristics between cryoballoon ablation and radiofrequency ablation with a contact force‐sensing catheter: Late‐gadolinium enhancement magnetic resonance imaging assessment
Authors: Kurose Jun , Kiuchi Kunihiko , Fukuzawa Koji , Takami Mitsuru , Mori Shumpei , Suehiro Hideya , Nagamatsu Yu‐ichi , Akita Tomomi , Takemoto Makoto , Yatomi Atsusuke , Nakamura Toshihiro , Sakai Jun , Watanabe Yoshiaki , Shimoyama Shinsuke , Negi Noriyuki , Kyotani Katsusuke , Hirata Ken‐ichi 
Published: July 2020

AbstractBackgroundPulmonary vein isolation (PVI) lesions after cryoballoon ablation (CBA) are characterized as a wider and more continuous than that after conventional radiofrequency catheter ablation (RFCA) without the contact force (CF)‐sensing technology. However, the impact on the lesion characteristics of ablation with a CF‐sensing catheter has not been well discussed. We sought to assess the lesions using late‐gadolinium enhancement magnetic resonance imaging (LGE‐MRI) and to compare the differences between the two groups (CB group vs. RF group).MethodsA total of 30 consecutive patients who underwent PVI were enrolled (CB group, 18; RF group, 12). The RF applications were delivered with a target lesion size index (LSI) of 5. The PVI lesions were assessed by LGE‐MRI 3 months after the PVI. The region around the PV was divided into eight segments: roof, anterior‐superior, anterior carina, anterior inferior, bottom, posterior inferior, posterior carina, and posterior superior segment. The lesion width and visual gap of each segment were compared between the two groups. The visual gaps were defined as no‐enhancement site of >4 mm.ResultsThe mean LSI was 4.7 ± 0.7. The lesion width was significantly wider but the visual gaps were more frequently documented at the bottom segment of right PV in the CBA group (lesion width: 8.1 ± 2.2 vs. 6.3 ± 2.2 mm; p = .032; visual gap at the bottom segment or right PV: 39% vs. 0%; p = .016).ConclusionsThe PVI lesion was wider after CBA, while the visual gaps were fewer after RFCA with a CF‐sensing catheter.
Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial
Authors: La Flamme Anne C , Abernethy David , Sim Dalice , Goode Liz , Lockhart Michelle , Bourke David , Milner Imogen , Garrill Toni-Marie , Joshi Purwa , Watson Eloise , Smyth Duncan , Lance Sean , Connor Bronwen 
Published: July 2020

ObjectiveBecause clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the Clozapine and Risperidone in Progressive Multiple Sclerosis (CRISP) trial was conducted to determine whether clozapine and risperidone are suitable for progressive multiple sclerosis (pMS).MethodsThe CRISP trial (ACTRN12616000178448) was a blinded, randomised, placebo-controlled trial with three parallel arms (n=12/arm). Participants with pMS were randomised to clozapine (100–150 mg/day), risperidone (2.0–3.5 mg/day) or placebo for 6 months. The primary outcome measures were safety (adverse events (AEs)/serious adverse events (SAE)) and acceptability (Treatment Satisfaction Questionnaire for Medication-9).ResultsAn interim analysis (n=9) revealed significant differences in the time-on-trial between treatment groups and placebo (p=0.030 and 0.025, clozapine and risperidone, respectively) with all participants receiving clozapine being withdrawn during the titration period (mean dose=35±15 mg/day). Participants receiving clozapine or risperidone reported a significantly higher rate of AEs than placebo (p=0.00001) but not SAEs. Specifically, low doses of clozapine appeared to cause an acute and dose-related intoxicant effect in patients with pMS who had fairly severe chronic spastic ataxic gait and worsening over all mobility, which resolved on drug cessation.InterpretationThe CRISP trial results suggest that patients with pMS may experience increased sensitivity to clozapine and risperidone and indicate that the dose and/or titration schedule developed for schizophrenia may not be suitable for pMS. While these findings do not negate the potential of these drugs to reduce multiple sclerosis-associated neuroinflammation, they highlight the need for further research to understand the pharmacodynamic profile and effect of clozapine and risperidone in patients with pMS.Trial registration numberACTRN12616000178448.
Discrete changes in brain volume after deep brain stimulation in patients with Parkinson’s disease
Authors: Kern Drew S , Uy Daniel , Rhoades Remy , Ojemann Steven , Abosch Aviva , Thompson John A 
Published: July 2020

ObjectivesDeep brain stimulation (DBS), targeting the subthalamic nucleus (STN) and globus pallidus interna, is a surgical therapy with class 1 evidence for Parkinson’s disease (PD). Bilateral DBS electrodes may be implanted within a single operation or in separate staged surgeries with an interval of time that varies patient by patient. In this study, we used the variation in the timing of implantation from the first to the second implantation allowing for examination of potential volumetric changes of the basal ganglia in patients with PD who underwent staged STN DBS.MethodsThirty-two patients with a mean time interval between implantations of 141.8 (±209.1; range: 7–700) days and mean duration of unilateral stimulation of 244.7 (±227.7; range: 20–672) days were included in this study. Using volumetric analysis of whole hemisphere and subcortical structures, we observed whether implantation or stimulation affected structural volume.ResultsWe observed that DBS implantation, but not the duration of stimulation, induced a significant reduction of volume in the caudate, pallidum, putamen and thalamus ipsilateral to the implanted hemisphere. These findings were not dependent on the trajectory of the implanted electrode nor on first surgery pneumocephalus (0.07%: %Δ for intracranial volume between first and second surgery). In addition, unique regional atrophy differences were evident in each of the structures.ConclusionOur results demonstrate that DBS implantation surgery may affect hemisphere volume at the level of subcortical structures connected to the surgical target.
Performance at stair-climbing test is associated with postoperative complications after lung resection: a systematic review and meta-analysis
Authors: Boujibar Fairuz , Gillibert André , Gravier Francis Edouard , Gillot Timothée , Bonnevie Tristan , Cuvelier Antoine , Baste Jean-marc 
Published: July 2020

BackgroundThoracic surgery is the optimal treatment for early-stage lung cancer, but there is a high risk of postoperative morbidity. Therefore, it is necessary to evaluate patients’ preoperative general condition and cardiorespiratory capacity to determine the risk of postoperative complications. The objective of this study was to assess whether the stair-climbing test could be used in the preoperative evaluation of lung resection patients to predict postoperative morbidity following thoracic surgery.MethodsWe performed a systematic review and a meta-analysis on the association between stair-climbing test result and morbidity/mortality after thoracic surgery. We analysed all articles published until May 2020 in the following databases: Pubmed/Medline, Pedro, The Cochrane library, Embase and CINAHL. The risk of bias was assessed using the Quality in Prognosis Studies tool. This meta-analysis is registered as PROSPERO CRD42019121348.Results13 articles were included in the systematic review for a total of 2038 patients and 6 in the meta-analysis. There were multiple test evaluation criteria: rise time, height, desaturation and heart rate change. For the meta-analysis, we were able to pool data on the height of rise at a variable threshold: risk ratio 2.34 (95% CI 1.59 to 3.43) with I²=53% (p=0.06). The threshold for occurrence of complications was estimated at a 10 m climb.ConclusionsOur results indicate that the stair-climbing test could be used as a first-line functional screening test to predict postoperative morbidity following thoracic surgery and that patients with a poor test result (<10 m) should be referred to formal cardiopulmonary exercise testing.
CROMqs: An infinitesimal successive refinement lossy compressor for the quality scores
Authors: No Albert , Hernaez Mikel , Ochoa Idoia 
Published: July 2020

The amount of sequencing data is growing at a fast pace due to a rapid revolution in sequencing technologies. Quality scores, which indicate the reliability of each of the called nucleotides, take a significant portion of the sequencing data. In addition, quality scores are more challenging to compress than nucleotides, and they are often noisy. Hence, a natural solution to further decrease the size of the sequencing data is to apply lossy compression to the quality scores. Lossy compression may result in a loss in precision, however, it has been shown that when operating at some specific rates, lossy compression can achieve performance on variant calling similar to that achieved with the losslessly compressed data (i.e. the original data). We propose Coding with Random Orthogonal Matrices for quality scores (CROMqs), the first lossy compressor designed for the quality scores with the “infinitesimal successive refinability” property. With this property, the encoder needs to compress the data only once, at a high rate, while the decoder can decompress it iteratively. The decoder can reconstruct the set of quality scores at each step with reduced distortion each time. This characteristic is specifically useful in sequencing data compression, since the encoder does not generally know what the most appropriate rate of compression is, e.g. for not degrading variant calling accuracy. CROMqs avoids the need of having to compress the data at multiple rates, hence incurring time savings. In addition to this property, we show that CROMqs obtains a comparable rate-distortion performance to the state-of-the-art lossy compressors. Moreover, we also show that it achieves a comparable performance on variant calling to that of the lossless compressed data while achieving more than 50% reduction in size.
A Study on N-Type Bismuth Sulphochloride (BiSCl): Efficient Synthesis and Characterization
Authors: Zhang H. , Sun S. H. , Liu J. C. , Hong F. , Zhu Y. , Zhou B. , Hu Y. M. 
Published: July 2020

Irregular rod-like bismuth sulphochloride (BiSCl) was synthesized by a high efficiency process in which BiCl3 and Bi2S3 were fully ground and mixed in N2 atmosphere followed by a sintering at 227∘C for 9 h to achieve crimson BiSCl powder. The products were characterized by X-ray powder diffraction (XRD) and scanning electronic microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDX). The BiSCl is an n-type semiconductor with a bandgap of 1.9 eV. In the temperature range of 300–500 K, thermal conductivity, electrical conductivity, Seebeck coefficient and thermoelectric figure of merit ZT of the BiSCl were tested and calculated. It is resulted that the BiSCl has a thermal conductivity of 0.45 Wm−1K−1 at 500 K and a Seebeck coefficient of −579 μVK−1 at 400 K. This work will help inform future in-depth studies on possible applications of BiSCl in the fields of thermoelectricity, optoelectronics and photocatalyticity.
A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels
Authors: Barfield Robyn M. , Kim Yun Cheol , Chuprakov Stepan , Zhang Fangjiu , Bauzon Maxine , Ogunkoya Ayodele O. , Yeo Dominick , Hickle Colin , Pegram Mark D. , Rabuka David , Drake Penelope M. 
Published: July 2020

Abstract
Trastuzumab and the related ADC, ado-trastuzumab emtansine (T-DM1), both target HER2-overexpressing cells. Together, these drugs have treatment indications in both early-stage and metastatic settings for HER2+ breast cancer. T-DM1 retains the antibody functionalities of trastuzumab and adds the potency of a cytotoxic maytansine payload. Interestingly, in the clinic, T-DM1 cannot always replace the use of trastuzumab plus chemotherapy administered together as single agents. We hypothesize that this failure may be due, in part, to the limited systemic exposure achieved by T-DM1 relative to trastuzumab because of toxicity-related dosing constraints on the ADC. We have developed a trastuzumab-based ADC site specifically conjugated to maytansine through a noncleavable linker. This construct, termed CAT-01-106, has a drug-to-antibody ratio (DAR) of 1.8, approximately half the average DAR of T-DM1, which comprises a mixture of antibodies variously conjugated with DARs ranging from 0 to 8. The high DAR species present in T-DM1 contribute to its toxicity and limit its clinical dose. CAT-01-106 showed superior in vivo efficacy compared with T-DM1 at equal payload dosing and was equally or better tolerated compared with T-DM1 at equal payload dosing up to 120 mg/kg in Sprague–Dawley rats and 60 mg/kg in cynomolgus monkeys. CAT-01-106 also showed improved pharmacokinetics in rats relative to T-DM1, with 40% higher ADC exposure levels. Together, the data suggest that CAT-01-106 may be sufficiently tolerable to enable clinical dosing at trastuzumab-equivalent exposure levels, combining the functions of both the antibody and the payload in one drug and potentially improving patient outcomes.
A study of the association between cognitive abilities and dietary intake in young women
Authors: Askari Masoumeh , Abbaszadeh Arefeh , Saharkhiz Mansoore , Karbasi Samira , Talebpour Amir , Fashami Akram Agha Amini , Rezapour Hadis , Hoseini Zahra Sadat , Mahmoudzadeh Sara , Ayadilord Malaksima , Ferns Gordon A , Bahrami Afsane 
Published: July 2020

Background: Cognitive abilities comprise activities that relate to receiving and responding to information from the environment, internal processing, making complex decisions, and then responding to this in the context of behavior. Aim: The current study investigated the association between dietary intake and seven aspects of cognitive abilities among healthy young women. Methods: The study was carried out among 182 women aged 18–25 years. A valid and reliable food frequency questionnaire containing 65 food items was used to estimate dietary intake. Neuropsychological function and cognitive abilities of participants were determined using standard questionnaires. Results: Significant differences were found in depression, anxiety, stress, physical, and mental health-related quality of life as well as daytime sleepiness for the participants in different quartiles of cognitive abilities score ( p<0.05). Participants in the fourth quartile of cognitive abilities score consumed significantly higher energy, carbohydrate, protein, calcium, iron, zinc, vitamin A, thiamin, and riboflavin compared to those in the lowest quartile ( p<0.05). There were strong correlations between total cognitive abilities score and dietary sodium, calcium, phosphorus, and thiamin ( p<0.05). Using stepwise multiple linear regression analysis, iron and thiamin were statistically significant factors for the prediction of cognitive abilities. Conclusions: These findings demonstrate that neurocognitive function is related to dietary macro and micronutrients including energy, carbohydrate, protein, calcium, iron, zinc, vitamin A, thiamin, and riboflavin on cognitive performance among young women without memory deficit.
Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents
Authors: Custodio Raly James Perez , Sayson Leandro Val , Botanas Chrislean Jun , Abiero Arvie , Kim Mikyung , Lee Hyun Jun , Ryu Hye Won , Lee Yong Sup , Kim Hee Jin , Cheong Jae Hoon 
Published: July 2020

Background: Recently, the recreational use of substituted phenethylamines has grown rapidly. Among these are 2-(3,5-dimethoxy-4-((2-methylallyl)oxy)phenyl)ethanamine (MAL) and 2-(2,5-dimethoxy-4-methylphenyl)-2-methoxyethan-1-amine (BOD). However, studies characterizing their abuse potential are still lacking. Aim: The purpose of this study was to investigate the abuse potential of MAL and BOD. Methods: The psychostimulant, reinforcing, and rewarding properties of MAL and BOD were analyzed using locomotor sensitization, self-administration, and conditioned place preference tests. Dopamine antagonists (i.e. SCH23390, haloperidol) were administered during conditioned place preference to evaluate the involvement of the mesolimbic dopamine system. Furthermore, dopamine-related protein expression in the nucleus accumbens and the ventral tegmental area was measured along with dopamine concentrations in the nucleus accumbens. Electroencephalography was conducted to determine effects of MAL and BOD on brain wave activity. Results: MAL induced psychostimulant effects and sensitization, while BOD induced locomotor depression in mice. Only MAL was self-administered by rats. Both drugs induced conditioned place preference in mice at different doses; dopamine receptor antagonists blocked MAL- and BOD-induced conditioned place preference. Both the compounds altered the expression of dopamine receptor D1 and D2 proteins in the nucleus accumbens and tyrosine hydroxylase (TH) and dopamine transporter in the ventral tegmental area, enhanced dopamine levels in the nucleus accumbens, and increased delta and gamma wave activities in the brain. Conclusions: MAL may induce abuse potential via the mesolimbic dopaminergic system and possibly accompanied by alterations in brain wave activity. Moreover, the lack of rewarding and reinforcing effects in BOD suggest that this drug may have little to no capability to engender compulsive behavior, though having found to induce alterations in dopaminergic system and brain wave activities.