bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loneliness as a risk factor for frailty transition among older Chinese people
Authors: SHA SHA , Xu Yuebin , Chen Lin 
Published: July 2020

Abstract
Background: Previous literature has reported that loneliness is a strong predictor of frailty risk. However, less is known about the role of loneliness in frailty transition types. This study aimed to examine whether and how loneliness are related to frailty transition among older Chinese people. Methods: Our study used participants (aged ≥60 years) from 2008/2009, 2011/2012 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Loneliness was assessed by a single question asking how often the respondent feels lonely. The FRAIL Scale was created to measure physical frailty for our study, and frailty was also assessed by a broader definition of the frailty index. Frailty transition as an outcome variable has been designed as two types according to the measurement of frailty.Results: Greater loneliness at baseline reduced the possibility of remaining in a robust or prefrail physical frailty state after 3 years (OR=0.78, 95%CI: 0.68–0.91, p<0.01). Greater loneliness was associated with an increased risk of worsening physical frailty over time: compared with those who had never felt lonely, the odds ratios for people who often felt lonely were 1.19 (95%CI: 1.01–1.41, p<0.05) after 3 years and 1.34 (95%CI: 1.08–1.66, p<0.01) after 6 years. The association between loneliness and change in the frailty index differed in the survey periods: loneliness at baseline was found to increase the possibility of participants remaining in frailty (seldom loneliness: OR= 1.78, 95%CI: 1.25–2.55, p<0.01; often loneliness: OR= 1.74, 95%CI: 1.21–2.50, p<0.01) after 6 years, but no significance was shown in the 3-year follow up. Additionally, loneliness at baselines was significantly associated with frailty transition at follow up among the male participants. However, a similar association was not observed among the female participants.Conclusion: Older people with a high level of loneliness tend to be frail in the future, and greater loneliness is related to an increased risk of worsening frailty and remaining frail. Male elderly with a high level of loneliness were more likely to have a worse frailty transition than female elderly in China.
Transcriptomic profiling revealed key signaling pathways for cold tolerance and acclimation of two carp species
Authors: Ge Guodong , Long Yong , Shi Lianyu , Ren Jing , Yan Junjun , Li Chitao , Li Qing , Cui Zongbin 
Published: July 2020

Abstract
Background Closely related species of the carp family ( Cyprinidae ) have evolved distinctive abilities to survive under cold stress, but molecular mechanisms underlying the generation of cold resistance remain largely unknow. In this study, we compared transcriptomic profiles of two carp species to identify key factors and pathways for cold tolerance and acclimation. Results Larvae of Songpu mirror carp and Barbless carp that were pretreated at 18°C for 24 hours significantly improved their survival rates under lethal cold temperature at 8°C or 10°C, indicating that two carp species possess the ability of cold acclimation. However, Songpu mirror carp exhibited stronger abilities of cold tolerance and acclimation than Barbless carp. Transcriptomic profiles of Songpu mirror carp and Barbless carp larvae at 28°C and 18°C were compared during cold acclimation through RNA-seq. Differentially expressed genes that are closely associated with the differences in cold acclimation between two carp species were identified through bioinformatics and Venn's diagram analysis. GO enrichment analysis of these genes indicated that cellular component assembly involved in morphogenesis, secondary alcohol metabolism and drug transport were the most up-regulated biological processes during cold acclimation of Songpu mirror carp. Conversely, positive regulation of macroautophagy, intracellular protein transport, and organonitrogen compound catabolism were the most down-regulated biological processes during cold acclimation of Barbless carp. KEGG enrichment analysis revealed that factors in the FoxO-related signaling pathways are mainly responsible for the development of differences in cold tolerance and acclimation between two carp species since altering the phosphorylation of key proteins in the FoxO-related signaling pathways with inhibitors or an activator significantly decreased the cold tolerance and acclimation of Songpu mirror carp. These data provided key clues for dissection of molecular mechanisms underlying the development of cold tolerance and acclimation in carps. Conclusions These findings indicate that larvae of two carp species possess different abilities of cold tolerance and can build cold acclimation under mild low temperature. Multiple biological processes and FoxO-related signaling pathways are closely associated with the development of differences in cold tolerance and acclimation between two carp species.
Performance of IRS on malaria prevalence and incidence using pirimiphos-methyl in the context of pyrethroids resistance in Koulikoro region, Mali
Authors: Kané Fousseyni , Keïta Moussa , Traoré Boïssé , Diawara Sory Ibrahim , Bane Sidy , Diarra Souleymane , Sogoba Nafomon , Doumbia Seydou 
Published: July 2020

Abstract
Background: Koulikoro Health District is one of three districts of Mali where the indoor residual spray (IRS) has been implemented from 2008 to 2016. With widespread of resistance to pyrothroid, IRS was shifted from pyrethroid to pirimiphos-methyl from 2014 to 2016. We assessed the added value of IRS to LLINs on the prevalence of parasitemia and malaria incidence among children under 10 years old. Methods: A comparative study was carried out to assess the effects of pirimiphos-methyl based IRS on malaria prevalence and incidence among children from 6 months to 10 years old in selected pyrethroid resistance villages of two health districts in Mali: one where IRS was implemented in combination with LLINs (intervention area) and one with LLINs-only (control area). Two cross-sectional surveys were carried out at the beginning (June) and end of the rainy season (October) to assess seasonal changes in malaria parasitemia by microscopy. A passive detection case (PCD) was set-up in each study village for 9 months to estimate the incidence of malaria using RDT. Results: There was an increase of 220% in malaria prevalence from June to October in the control area (14% to 42%) versus only 53% in the IRS area (9.2% to 13.2%).Thus, the proportional rise in malaria prevalence from the dry to the rainy season in 2016 was 4 times greater in the control area compared to the IRS area. The overall malaria incidence rate was 2.7 per 100 person-months in the IRS area compared with 6.8 per 100 person-month in the control areas. The Log-rank test of Kaplan-Meier survival analysis showed that children living in IRS area remain much longer free from malaria (Hazard ratio (HR)=0.45, CI 95% = 0.37-0.54) than children of the control area (P < 0.0001).Conclusions: IRS using pirimiphos-methyl has been successful in reducing substantially both the prevalence and the incidence of malaria in children under 10 years old in the area of pyrethroid resistance of Koulikoro, Mali. Pirimiphos-methyl is a better alternative than pyrethroids for IRS in areas with widespread of pyrethroid resistance.
The Feasibility of Laparoscopic TSME Preserving the Left Colic Artery and Superior Rectal Artery for Upper Rectal Cancer
Authors: Zhang Chi , Wei Hao-tang , Hu Wenqing , Sun Yueming , Zhang Qinyuan , Abe Masanobu , Du Zhuoran , Xu Yingying , Zong Liang , Hu Xiang 
Published: July 2020

Abstract
Background Laparoscopic TSME preserving the left colic artery and superior rectal artery is still a technically challenging procedure. We conducted this study to demonstrate the feasibility of this procedure for upper rectal cancer. Methods A total of 184 patients with upper rectal cancer were retrospectively analyzed in our cancer center between April 2010 and April 2017. These patients were treated with either laparoscopic TSME (n=46) or laparoscopic TME (n=138). In the TSME group, the left colonic artery and superior rectal artery were preserved while they were not in the TME group. Results The operation time in the TSME group was longer than that in the TME group (218.56 ± 35.85 min vs. 201.13 ± 42.65 min, P=0.004). Furthermore, the number of resected lymph nodes in the TSME group was greater than that in the TME group (19.43 ± 9.46 vs. 18.03 ± 7.43, P=0.024). The blood loss between the TSME and TME groups was not significant. No mortality occurred in either the TSME or TME groups. One patient in the TME group underwent conversion to laparotomy. The total postoperative complication rates in the TSME and TME groups were 8.7% and 17.4%, respectively. There was no difference in severe complications between the two groups (anastomotic leakage and stenosis).Conclusions Laparoscopic TSME preserving the left colic artery and superior rectal artery can be safely conducted for upper rectal cancer. [1]
Night sleep duration and risk of each lipid profile abnormality in a Chinese population: a prospective cohort study
Authors: Song Qiaofeng , Liu Xiaoxue , Zhou Wenhua , Wu Shouling , wang xizhu 
Published: July 2020

Abstract
Background To explore the associations between sleep duration and abnormalities in serum lipid levels in a Chinese population. Methods A prospective study was conducted with 34,260 participants from the general Chinese population. Sleep duration was categorized as ≤5, 6, 7, 8 or ≥9 h. Each lipid profile abnormality was defined according to the Chinese Guidelines for the Prevention and Treatment of Dyslipidemia in Adults (2016). The Cox proportional hazards model was used to assess the association between sleep duration and dyslipidemia. Results Compared with a 7 h sleep duration, long sleep duration (≥9 h) was significantly associated with low high-density lipoprotein cholesterol (HDL-C) levels (hazard ratio (HR): 1.24; 95% CI: 1.12–1.38). In subgroup analyses, the positive association between long sleep duration and low HDL-C level in men and in the different age groups was more pronounced than the association in women. No significant interactions were observed in the association between sleep duration and each abnormal serum lipid level by sex/age in the study population (P-interaction>0.05). Conclusions These findings suggest that long sleep duration is associated with low HDL-C level among the Kailuan community population.
Mental health, smoking, harm reduction and quit attempts – a population survey in England
Authors: Brose Leonie , Brown Jamie , Robson Debbie , McNeill Ann 
Published: July 2020

Abstract
Background: Tobacco control strategies have engendered overall declines in smoking; however, a large gap remains between people with and without mental health problems, causing substantial health inequalities. Population-level information on barriers and opportunities for improvements is scarce. We aimed to assess mental health status of cigarette smokers and recent ex-smokers (‘past-year smokers’) in England, and smoking and harm reduction behaviour and quit attempts by mental health status.Methods: Data were collected from 5,637 current and 434 recent ex-smokers in 2016/17 in household surveys of representative samples of adults. We calculated weighted prevalence of different indicators of mental health problem: a) ever diagnosis, b) none, moderate, serious past-month distress, c) past-year treatment. We compared weighted smoking status, cigarette type, dependence, motivation to stop smoking, cutting down, use of nicotine replacement therapy or e-cigarettes, short-term abstinence, and quit attempts according to mental health status. Results: Among past-year smokers: 35.9% ever had a diagnosis; 24.3% had experienced moderate, an additional 9.7% serious, past-month distress; 21.9% had had past-year treatment. Those with an indication of a mental health problem were more highly dependent and more likely to smoke roll-your-own cigarettes but also more likely to be motivated to stop smoking, to cut down, use nicotine replacement therapy or e-cigarettes and to have attempted to quit in the past year.Conclusions: About a third of cigarette smokers in England have mental health problems. Interventions should address their increased dependence and leverage higher prevalence of harm reduction behaviours, motivation to stop and attempts to stop smoking.
Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions
Authors: Wang Ruoning , Yang Yujie , Yang Mengmeng , Yuan Dandan , Huang Jinyu , Chen Rui , Wang Honglan , Hu Lihong , Di Liuqing , Li Junsong 
Published: July 2020

Abstract
Background: The management of metastatic cancer remains a major challenge in cancer therapy worldwide. The targeted delivery of chemotherapeutic drugs through rationally designed formulations is one potential therapeutic option. Notably, excipient-free nanodispersions that are entirely composed of pharmaceutically active molecules have been evaluated as promising candidates for the next generation of drug formulations. Formulated from the self-assembly of drug molecules, these nanodispersions enable the safe and effective delivery of therapeutic drugs to local disease lesions. Here, we developed a novel and green approach for preparing nanoparticles via the self-assembly of rhein (RHE) and doxorubicin (DOX) molecules, named RHE/DOX nanoparticles (RD NPs); this assembly was associated with the interaction force and did not involve any organic solvents. Results: According to molecular dynamics (MD) simulations, DOX molecules tend to assemble around RHE molecules through intermolecular forces. This intermolecular retention of DOX was further improved by the nanosizing effect of RD NPs. Compared to free DOX, RD NPs exerted a slightly stronger inhibitory effect on 4T1 cells in the scratch healing assay. As a dual drug-loaded nanoformulation, the efficacy of RD NPs against tumor cells in vitro was synergistically enhanced. Compared to free DOX, the combination of DOX and RHE in nanoparticles exerted a synergistic effect with a combination index (CI) value of 0.51 and showed a stronger ability to induce cell apoptosis. Furthermore, the RD NP treatment not only effectively suppressed primary tumor growth but also significantly inhibited tumor metastasis both in vitro and in vivo, with a better safety profile. Conclusions: The generation of pure nanodrugs via a self-assembly approach might hold promise for the development of more efficient and novel excipient-free nanodispersions, particularly for two small molecular antitumor drugs that potentially exert synergistic antiproliferative effects on metastatic breast cancer.
Tumor Response Prediction in 90Y Radioembolization with PET-based Radiomics Features and Absorbed Dose Metrics
Authors: Wei Lise , Cui Can , Xu Jiarui , Kaza Ravi , Naqa Issam El , Dewaraja Yuni K 
Published: July 2020

Abstract
Purpose Evaluate whether lesion radiomics features and absorbed dose metrics extracted from post-therapy 90Y PET can be integrated to better predict outcome in microsphere radioembolization of liver malignancies. Methods Given the noisy nature of 90Y PET, first, a liver phantom study with repeated acquisitions and varying reconstruction parameters was used to identify a subset of robust radiomics features for the patient analysis. In 36 radioembolization procedures, 90Y PET/CT was performed within a couple of hours to extract 46 radiomics features and estimate absorbed dose in 105 primary and metastatic liver lesions. Robust radiomics modeling was based on bootstrapped multivariate logistic regression with shrinkage regularization (LASSO) and Cox regression with LASSO. Nested cross-validation and bootstrap resampling were used for optimal parameter/feature selection and for guarding against overfitting risks. Spearman rank correlation was used to analyze feature associations. Area under the receiver-operating characteristics curve (AUC) was used for lesion response (at first follow-up) analysis while Kaplan-Meier plots and c-index were used to assess progression model performance. Models with absorbed dose only, radiomics only and combined models were developed to predict lesion outcome.Results The phantom study identified 15/46 reproducible and robust radiomics features that were subsequently used in the patient models. A lesion response model with zone percentage (ZP) and mean absorbed dose achieved an AUC of 0.729 (95%CI: 0.702-0.758) and a progression model with zone size nonuniformity (ZSN) and absorbed dose achieved a c-index of 0.803 (95% CI: 0.790-0.815) on nested cross validation (CV). The combined models outperformed the radiomics only and absorbed dose only models, but statistical significance was not achieved with this limited data set.Conclusion We have developed new lesion-level response and progression models using textural radiomics features, derived from 90Y PET combined with mean absorbed dose for predicting outcome in radioembolization. These encouraging results will need further validation in independent datasets prior to clinical adoption.
Live birth rates in different subgroups of poor ovarian responders according to Bologna and POSEIDON group classification criteria
Authors: Mashayekhy Mehri , Arabipoor Arezoo , Barabi Forouzan , Zolfaghari Zahra 
Published: July 2020

Abstract
Background: Live birth rates (LBRs) have been separately evaluated in two poor ovarian responder (POR) classification methods. We designed the present study to compare the LBRs according to Bologna criteria or Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number (POSEIDON) group classifications to determine the important predictive factors for LBR in patients with POR. Methods: In this cross-sectional study, we evaluated a database that contained clinical and laboratory information on infertility treatment cycles of all patients with at least one POR after standard controlled ovarian stimulation (COH) during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles from December 2015 to December 2017. The eligible data were collected and the subjects divided into five groups according to Bologna criteria and four groups according to POSEIDON group classification. Results: We assessed 812 patients diagnosed with POR; overall, 517 underwent embryo transfer (ET) during the last treatment cycle (63.6%). The results indicated a total clinical pregnancy rate of 19.3% (100 cases) and LBR of 16.1% (86 cases). According to Bologna criteria, 41 patients were not included in any group. Analysis of treatment cycle outcome showed that patients classified as Bologna group II had a higher LBR than the other groups. In terms of POSEIDON classification, all of the patients could be classified into groups. Patients in POSEIDON group 3 had the highest LBR. According to multivariable regression analysis, the significant independent variables that remained in the model as important predictive factors for live births were the number and quality (good and excellent) of the embryos transferred, and POSEIDON group 3 classification. Conclusion: The results indicated that the POSEIDON group classification could be more comprehensive and practical than Bologna criteria for diagnosing and categorizing POR patients. In addition, we noted that the number and quality of transferred embryos were the most important prognostic factors for live births in POR patients. Therefore, we suggest that clinicians consider COH protocols that have a freezing embryo strategy and the collection of more good quality embryos to improve the probability of a live birth.
Validation of the Arabic version of the Perinatal Anxiety Screening Scale (PASS) among antenatal and postnatal women
Authors: Jr Hoda , Alfarhan Thikrayat , Alsuraimi Anas 
Published: July 2020

Abstract
Background Anxiety among women in the perinatal period is common. Assessing the severity of perinatal anxiety will help monitor the progress of the patient through the stages of anxiety and facilitated the treatment. This study assesses the validity and reliability of the “Perinatal Anxiety Screening Scale” (PASS) in the Arabic language. Methods The PASS was translated into Arabic. 217 women in the antenatal and postnatal phase participated (92 antenatal and 125 postnatal) answered to PASS, GHQ12, EPDS-10, and DASS-21. Content validity, factor analysis, internal consistency, and test retest reliability were assessed. Results Content Validity Index (CVI) and Content Validity Ratio (CVR) were .88 and 0.79; respectively. The scale loaded on four components: acute anxiety, social anxiety, and dissociation; specific fears and trauma; general anxiety and adjustment; and perfectionism and control. Cronbach’s Alpha value for the scale was 0.78 and test retest correlation coefficient was 0.94. PASS significantly correlated with EPDS-10 (rho=0.46), GHQ-12(rho=0.58), the three components of DASS-21 (0.47, 0.50, and 0.43; respectively), and experiencing adverse life events Conclusion The Arabic translated version of the PASS showed reasonably adequate validity and reliability and can be used to screen for anxiety disorder among women in the perinatal phase.
From Dyad To Triad: A Survey On Fathers’ Knowledge And Attitudes Toward Breastfeeding
Authors: Crippa Beatrice Letizia , Consales Alessandra , Morniroli Daniela , Lunetto Flavia , Bettinelli Maria Enrica , Sannino Patrizio , Rampini Serena , Zanotta Lidia , Marchisio Paola , Mosca Fabio , Plevani Laura , Giannì Maria Lorella , Colombo Lorenzo 
Published: July 2020

Abstract
Background Maternal social support has a critical impact on breastfeeding outcomes. Fathers, in particular, are known to be especially influential. We aimed to explore paternal knowledge and attitude toward breastfeeding, and possible association with breastfeeding rates at discharge, in a cohort of fathers from an Italian tertiary referral center for neonatal care.Methods In this cross-sectional study, we enrolled fathers of healthy term neonates born at our hospital from March to May 2019. At discharge, a self-administered structured questionnaire was proposed to fathers. Fathers were required to rate their degree of agreement to 12 items on a 5-point Likert scale. A total score was obtained from their answers. A higher score was indicative of a greater knowledge/positive attitude toward breastfeeding. Subjects’ basic characteristics and mode of feeding at discharge were collected.Results Fathers showed a generally solid knowledge of maternal (87%) and neonatal (98%) benefits of breastfeeding, skin-to-skin (99.5%), rooming-in (79%), and responsive feeding (67.5%); conversely, only 51% knew about the recommended use of pacifiers. Fathers felt personally involved in their babies' feeding in 79% of cases, regardless of the type of feeding. A positive association was found between total score and exclusive breastfeeding rates at discharge (p = 0.04, OR 1.07; 95% C.I 1.002-1.152). Conclusions This study underlines the importance of including fathers in the promotion of breastfeeding, expanding the classic mother-baby dyad to a more modern mother-father-baby triad. This aspect may ultimately impact breastfeeding outcomes, although further studies are needed to confirm our results.