bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutfak Çalışanlarında Algılanan Dışsal Prestij ve İşe Adanmışlığının Yenilik Performansına Etkisi: Nevşehir İlinde Bir Uygulama
Authors: BALKI Selcen , İLHAN İbrahim , ÖZKOÇ Aziz 
Published: July 2020

Bu çalışmanın amacı,
Nevşehir ilinde faaliyet gösteren konaklama işletmelerinde mutfak personelinin
algılanan dışsal prestij ve işe adanmışlığa yönelik eğilimlerini ölçerek
yenilik performansına etkisini belirlemektir. Bu amaçla, algılanan dışsal
prestij, işe adanmışlık ve yenilik performansı arasındaki etkileşimin teorik
arka planı irdelenerek yapısal bir model önerilmiş ve bu model uygun
istatistiksel analizler ile test edilmiştir. Çalışma kapsamına Nevşehir ilinde faaliyet
gösteren konaklama işletmelerinde görev yapan mutfak çalışanları dahil edilmiştir.
Veriler anket tekniği ile toplanmıştır. Araştırma sonucunda algılanan dışsal
prestij ile işe adanmışlık arasında pozitif yönlü anlamlı bir etkileşimin
olduğu ve ayrıca bu iki bağımsız değişkenin yenilik performansını olumlu yönde
etkilediği sonucuna ulaşılmıştır.
Target-Templated de novo Design of Macrocyclic D-/L-Peptides: Inhibitors of the PD-1/PD-L1 Interaction
Authors: Guardiola Salvador , Varese Monica , Roig Xavier , Garcia Jesús , Giralt Ernest 
Published: July 2020

NOTE: This preprint has been retracted by consensus from all authors. See the retraction notice in place above; the original text can be found under "Version 1", accessible from the version selector above.------------------------------------------------------------------------Peptides, together with antibodies, are among the most potent biochemical tools to modulate challenging protein-protein interactions. However, current structure-based methods are largely limited to natural peptides and are not suitable for designing target-specific binders with improved pharmaceutical properties, such as macrocyclic peptides. Here we report a general framework that leverages the computational power of Rosetta for large-scale backbone sampling and energy scoring, followed by side-chain composition, to design heterochiral cyclic peptides that bind to a protein surface of interest. To showcase the applicability of our approach, we identified two peptides (PD-i3 and PD-i6) that target PD-1, a key immune checkpoint, and work as protein ligand decoys. A comprehensive biophysical evaluation confirmed their binding mechanism to PD-1 and their inhibitory effect on the PD-1/PD-L1 interaction. Finally, elucidation of their solution structures by NMR served as validation of our de novo design approach. We anticipate that our results will provide a general framework for designing target-specific drug-like peptides.
PENGEMBANGAN MODUL PEMBELAJARAN SENI RUPA KOMPETENSI DESAIN POSTER UNTUK SMA
Authors: Nurfadilah Nurfadilah , Arifin Irfan , Ahmad Abd Aziz 
Published: July 2020

Penelitian ini bertujuan: untuk membuat modul pembelajaran desain poster yang mengacu pada model pengembangan 4-D. Modul ini diperuntukkan bagi siswa Sekolah Menengah Atas, berisi materi tentang teknik mendesain poster. Responden yang terlibat pada penelitian pengembangan ini adalah 2 (dua) orang yaitu ahli materi dan ahli media. Data yang digali dalam penelitian ini adalah data validasi dari dosen ahli materi dan ahli media berupa aspek isi materi, aspek tampilan sampul (cover), dan aspek tampilan isi. Analisis data pada penelitian ini menggunakan teknik analisis deskriptif kuantitatif yang dikonversikan ke data kualitatif. Hasil penelitian menunjukkan bahwa nilai yang diperoleh dari validasi ahli terhadap aspek isi, aspek tampilan sampul (cover), dan aspek tampilan isi pada modul yang dikembangkan keseluruhan masuk dalam kategori bagus dan jelas, dengan rata-rata nilai aspek isi 4.43 atau 34,1%, aspek tampilan sampul 4.14 atau 31.8%, dan aspek tampilan isi 4.13 atau 34.1% yang jika dikonverskan dari rata-ratanya 4.23 untuk keseluruhan aspek modul mendapat nilai B dengan ketegori “Jelas dan Bagus”. Sesuai dengan kriteria yang telah ditentukan, yaitu jika hasil penilaian ahli materi dan media dinyatakan baik maka produk yang dikembangkan telah memenuhi persyaratan dan layak digunakan sebagai media pembelajaran desain poster untuk siswa Sekolah Menengah Atas.
The Rhetoric of “Whataboutism” in American Journalism and Political Identity
Authors: Dykstra Alan 
Published: July 2020

This paper is focused on the contextual use of the term “whataboutism” in contemporary American politics, specifically in the language of political news commentary. After tracking the word’s emergence in political discourse, some analysis of the term’s recent use in examples of commentary articles is done to explore what the term means as a rhetorical device that structures political conversations in the media and shapes political identities in the public sphere. Overall, “whataboutism” is found to be part of an asymmetrical media ecosystem polarizing the American electorate, and one of the rhetorical tools systematically used in maintaining political group divisions. How “whataboutism” is deployed in political discourse and then grappled with or normalized by journalists is emblematic of trends in American journalistic discourse after the election results of 2016, and the term’s newfound prevalence is illustrative of the degree to which American identities have become politically tribalized.
Implementasi Pendekatan Contextual Teaching and Learning pada Pembelajaran Qur’an Hadits
Authors: Suriadi Suriadi , Supriyatno Triyo , Walid Muhammad 
Published: July 2020

<p>Artikel ini membahas tentang pembelajaran qur’an hadits dengan pendekatan <em>contextual teaching and learning</em>. Kajian ini difokuskan pada pembelajaran qur’an hadits. Penelitian bertujuan untuk menguraikan pembelajaran <em>contextual teaching and learning</em> pada: a) pelaksanaan pembelajaran Qur’an Hadits di madrasah tsanawiyah Muhammadiyah Sejangkung Kabupaten Sambas, b) Faktor yang menjadi masalah dalam pelaksanaan pembelajaran Qur’an Hadits di pada madrasah tsanawiyah Muhammadiyah Sejangkung Kabupaten Sambas, (c) upaya-upaya yang dilakukan dalam mengatasi masalah dalam pembelajaran Qur’an Hadits madrasah tsanawiyah Muhammadiyah Sejangkung Kabupaten Sambas. Penelitian ini didesain dengan pendekatan kualitatif. Subjek penelitian adalah kepala sekolah, pendidik, dan siswa pada Qur’an Hadits di madrasah tsanawiyah Muhammadiyah Sejangkung Kabupaten Sambas Provinsi Kalimantan Barat. Hasil analisis menunjukkan bahwa madrasah tsanawiyah Muhammadiyah Sejangkung dalam penyelenggaraan pembelajaran Hadits, secara falsafi mengikuti langkah-langkah yang didasarkan kepada Al-Quran dan Hadits, sedangkan secara teknis operasional cenderung menggunakan model <em>Mastery Learning</em> dengan pendekatan<em> Contextual Teaching and Learning</em>. Hal ini berarti pola pembelajaran Hadits di Madrasah Tsanawiyah Swasta Sejangkung mendukung model <em>Mastery Learning</em> dengan pendekatan <em>Contextual Teaching and</em> <em>Learning</em>, sebab teri-teori dari kedua konsep ini membuktikan kebenaran al-Qur’an dan dan Keteladan Nabi Muhammad yang jauh lebih dulu lahir sebelum asas-asas yang terdapat dalam model-model pembelajaran pada saat sekarang. Dengan demikian model pembelajaran <em>Mastery Learning</em> dengan pendekatan <em>Contetextual Teaching and Learning</em> berpeluang untuk digunakan dalam pembelajaran Hadits di Madrasah.<strong></strong></p>
Korai idegrendszeri károsodások: korai diagnosztika, prognózis és terápia
Authors: Berényi Marianne , Katona Ferenc 
Published: July 2020

A korai – részben veleszületett – idegrendszeri károsodások felismerése, az agy morfológiai és funkcionális állapotának a megítélése, a prognózis megállapítása és a szükséges terápiák bevezetése rendkívül felelősségteljes orvosi feladat. A központi idegrendszer fejlődése születés után a humán genetikai program és a külső hatások alapján tovább folyik. A fő kérdés, hogy az elszenvedett károsodások mennyiben befolyásolhatják mindezt, hogyan és milyen irányban változtathatják ezt a folyamatot. Mind a mozgás, mind a figyelem és az értelem az emberre jellemző humán specifikus, együttes kialakulása ettől az agyi fejlődéstől függ. A korai diagnózisnak és prognózisnak a meglévő és a várható károsodásokra kell következtetnie ahhoz, hogy a szükséges, megelőző terápia időben megindulhasson. A következőkben először a diagnosztikai és terápiai módszereket foglaljuk röviden össze, mert metodikai leírás nélkül semmiféle módszer alkalmassága, hatékonysága nem ítélhető meg.
Status of Anemia among Undergraduate Students of a Medical College of Central Nepal
Authors: Timilsina Sameer , Yadav Ram Lochan , Bhusal Pujan , Khatri Niraj , Islam Md Nazrul 
Published: July 2020

Background: Anemia is a public health concern with adverse health consequences. The vast nature of medical curriculum demands rigorous efforts and stress putting health science students at risk of anemia. In the present study, we aim to estimate the hemoglobin level of undergraduate health science students at Chitwan Medical College.
Methods: This cross-sectional study included all 386 year I and II undergraduate health science students enrolled at Chitwan Medical College. An informed consent was obtained from all the participants and hemoglobin values were obtained using Sahli’s hemoglobinometry at Physiology laboratory of basic science complex during March to August 2019. Ethical approval was obtained from CMC-IRC (Ref: CMC-IRC/075/076-125). Chi-squared test was done to seek the association of various demographic factors with hemoglobin values.
Results: Anemia was found among 37.8% undergraduate health science students as per World Health Organization (WHO) criteria. A total of 44.7% males and 32.3% females were found to have anemia. Statistical significant association was observed between body mass index (BMI) and hemoglobin level with higher BMI contributing to higher hemoglobin values. There was no association of hemoglobin level with sex, place of origin and stream of study.
Conclusions: Almost 4 out of 10 undergraduate medical students enrolled at Chitwan Medical College had lower hemoglobin values for age and sex as suggested by WHO.
Keywords: anemia, health science, hemoglobin, students, undergraduate
VASCULAR ENDOTHELIAL GROWTH FACTOR AS A MARKER OF ENDOTHELIAL DYSFUNCTION IN THE PREGNANT WOMEN WITH OBESITY
Authors: Zelinka-Khobzey M.M. 
Published: July 2020

Today, obesity is one of the most common diseases worldwide and is a risk factor for obstetric and perinatal complications. Therefore, the purpose of the study is to determine the vascular endothelial growth factor in the blood serum of pregnant women with physiological body weight and obesity of varying degrees in the first and third trimesters of gestation. Materials and methods. The subjects were divided into 6 groups. The first group (control) consisted of pregnant women with physiological body weight in the first trimester; the second group included pregnant women with physiological body weight in the third trimester; the third group involved pregnant women with obesity Class I in the first trimester (20 women in each group); the fourth group - pregnant women with obesity of Class I in the third trimester (15 women); the fifth group - pregnant women with obesity of Classes II – III in 1st trimester (20 women); the sixth group – pregnant women with obesity of Classes II – III in the third trimester (15 women). Results and discussion. The article presents the evaluation of angiogenesis in pregnant women with physiological body weight and in pregnant women with concomitant obesity. The analysis of the results obtained has demonstrated the following pattern: the blood serum angiogenic factor decreases as obesity increases over I and III trimesters. Conclusions: 1. The endothelial growth factor of blood vessels in pregnant women with physiological body weight increases as pregnancy progresses. 2. Сoncentration of vascular endothelial growth factor in the serum of pregnant women with concomitant obesity in the 1st and 3rd trimesters of pregnancy naturally decreases with increasing severity of obesity, and its indicators in pregnant women with obesity in the 1st trimester can be used to predict the occurrence of obstetric complications associated with obesity.
Quantification of polysorbate 80 in biopharmaceutical formulations implementing an optimized colorimetric approach
Authors: Seregin A. S. , Orlova N. V. , Askretkov A. D. , Zybin D. I. , Seregin Yu. A. 
Published: July 2020

Objectives. We hereby describe an improvement of a previously developed quantification technique for polysorbate 80 in biopharmaceutical formulations (darbepoetin alfa and eculizumab) and report the validation of the new approach.Methods. Polysorbate was isolated from analyte samples by protein precipitation using an organic solvent, followed by supernatant evaporation in vacuum. Polysorbate was derivatized using a ferric thiocyanate reagent and extracted into an organic phase; the relevant optical density measurements were performed.Results. We established the optimal conditions for each step of the analysis procedure. The accuracy was 97–102% in the tested analytical range, the relative standard deviation did not exceed 5%, and the limit of quantification was 0.01 mg/mL.Conclusions. The reported approach is highly sensitive; polysorbate isolation and quantification do not depend on the matrix or, most importantly, the protein.
FORMANT CHARACTERISTICS OF MALAY VOWELS OF PERLIS, KELANTAN AND TERENGGANU
Authors: Jamil Nursuriati , Ramli Izzad , Ardi Norizah 
Published: July 2020

The pronunciation of Malay vowels are taught according to the International Phonetic Association transcription sound chart. The documentation for pronunciations are conducted by describing and distinguishing the vowelâ€™s sound through impressionistic. In the last five years, several studies were carried out to quantify the standard Malay vowels pronunciation using formant frequencies. However, only one work was identified that measures Malay vowels using formant frequencies for the Kedah district. Nonetheless, there were contradiction in some of the findings as the spoken vowels wereextracted from a read speech, that may not be representative of the natural dialect. Therefore, this paper investigated the Malay vowels variations from three districts (Perlis, Kelantan, and Terengganu) using spontaneous speeches acquired in a natural setting. Eight (8) Malay vowels were collected from local males and females residing in Perlis, Kelantan, and Terengganu. Four formant frequencies (F1-F4) were measured from the vowels extracted from the spontaneous speeches of the locals. Further analysis on the first and second formant suggest that the Malay vowels of Terengganu and Kelantan have a broader range of formants that are located in approximately the same position in the mouth. However, the vowels of the Perlis dialects were closely positioned in a narrower region of the mouth. A Malay vowel diagram was plotted that can be used for future reference in research and as an educational tool for language learning. Furthermore, Kelantan and Terengganu dialects are shown to be similar based on the first and second formants.
Upaya Meningkatkan Hasil Belajar Matematika Pada Materi Teorema Phytagoras Dengan Menggunakan Model Pembelajaran Numbered Heads Together (NHT) berbasis multimedia
Authors: Tahun Ardy Imanuel , Kelen Yoseph P.K 
Published: July 2020

Artikel ini berjudul ‘‘Upaya Meningkatkan Hasil Belajar Matematika Pada Materi Teorema Phytagoras Dengan Menggunakan Model Pembelajaran Numbered Heads Together (NHT) berbasis multimedia”, Bagaimana penerapan Numbered Heads Together (NHT) berbasis Multimedia agar dapat meningkatkan hasil belajar matematika pada materi teorema phytagoras ?, Tujuan penelitian ini adalah untuk meningkatkan hasil belajar matematika pada materi teorema phytagoras dengan menggunakan model pembelajaran Numbered Heads Together (NHT) berbasis multimedia. Jenis penelitian ini adalah Penelitian Tindakan Kelas(PTK) yang dilaksanakan dalam 2 siklus melalui 4 tahap pelaksanaan yaitu perencanaan, tindakan, observasi dan refleksi. Subjek dalam penelitian ini adalah siswa kelas VIIIA di SMP Negeri Tobala pada semester genap Tahun 2018/2019 yang berjumlah 20 orang. Alat pengumpulan data dalam penelitian ini adalah lembar observasi dan soal tes dalam bentuk uraian yang terdiri dari 5 (tujuh butir soal). Penelitian dilaksanakan dalam dua siklus dan masing- masing siklus terdiri dari dua kali pertemuan dimana pertemuan pertama yaitu proses belajar mengajar dan pertemuan kedua yaitu melakukan tes. Dengan Indikator keberhasilan ketuntasan klasikal adalah 75%. Hasil penelitian menunjukan bahwa dengan menggunakan model pembelajaran numbered heads together (NHT) hasil belajar siswa meningkat ,hal tersebut dibuktikan pada siklus I persentase ketuntasan 65% siswa yang mengikuti tes 19 0rang atau 1 tidak hadir, yang tuntas 13 orang , dan aktivitas siswa cukup baik serta akitivitas guru juga baik. Sedangkan pada siklus II jumlah siswa 20 orang, 17 orang tuntas dengan kategori sangat baik untuk siswa dan guru. Dengan demikian, peneliti menyimpulkan bahwa dengan model pembelajaran numbered heads together (NHT) dapat meningkatkan hasil matematika materi teorema phytagoras pada siswa SMP Negeri Tobala tahun ajaran 2018/2019.©2018 dipublikasikan oleh JSLK.
MOTIVASI DAN PRESTASI BELAJAR MATEMATIKA SISWA PADA PEMBELAJARAN MODEL KOOPERATIF TIPE TPS
Authors: Liunome Aprisa V. , Daniel Farida , Taneo Prida N. L. 
Published: July 2020

Motivasi merupakan salah satu faktor pendukung dalam mencapai prestasi belajar matematika. Motivasi sebagai penggerak melalui usaha, dapat berpengaruh positif terhadap prestasi belajar matematika siswa. Hasil observasi di SMK Teknik Anugerah Soe menunjukkan bahwa prestasi belajar matematikasiswa masih rendah. Penyebabnya yaitusiswa lebih senang bekerja mandiri, kurang berpartisipasi dalam aktivitas belajar serta kurangnya kreativitas guru dalam mendesain pembelajaran. Salah satu alternatif untuk mengatasi permasalahan di atas adalah dengan pembelajaran model kooperatif tipe TPS. Tujuan penelitian ini adalah 1) menghasilkan kajian tentang pengaruh motivasi terhadap prestasi belajar matematika siswa pada pembelajaran model kooperatif tipe TPS; 2) meningkatkan prestasi belajar matematika siswa pada pembelajaran model kooperatif tipe TPS. Penelitian ini menggunakan metode kuantitatif model pre-eksperimental dengan rancangan one group pretest- posttestdesign melibatkan satu kelas penelitian dengan teknik purposive sampling. Instrumen yang digunakan sebagai alat pengumpulan data adalah tes berupa soal uraian, angket dan observasi. Teknik analisis data dalam penelitian ini menggunakan uji regresi, uji t-sampel berpasangan dan skor gain. Hasil analisis menunjukkan bahwa 1) terdapat pengaruh motivasi terhadap prestasi belajar matematika pada pembelajaran model kooperatif tipe TPS; 2)terdapat peningkatan prestasi belajar matematika siswa pada pembelajaran model kooperatif tipe TPS yang berada pada kategori tinggi dengan rata-rata skor gain 0,76.
Jerome Zanchi, the Application of Theology, and the Rise of the English Practical Divinity Tradition
Authors: O'Banion Patrick J. 
Published: July 2020

Cet article s'inscrit dans le débat récemment relancé sur la relation entre les théologiens scolastiques de la Réforme et les premiers réformateurs, mais propose également de l'amener dans une nouvelle direction. On y analyse d'abord la doctrine de Dieu, telle que développée par Jerome Zanchi (1516-1590), en mettant en relief comment il passe de conclusions de théologie systématique à des implications de théologie pratique, en particulier, à travers son usage de la convention dite de l'usus doctrinae. L'article cherche ensuite à estimer l'impact de cette convention en dehors des milieux érudits en explorant la relation entre le discours de Zanchi et la tradition anglaise pratique de la divinité. On y met donc en lumière comment les pasteurs et les théologiens populaires ont emprunté à Zanchi dans le cadre de leur charge
d'âmes et de réforme de la nation anglaise.
IMIGRANTES E AGENDA POLÍTICO-ELEITORAL: A VISIBILIDADE DA IMIGRAÇÃO INTERNACIONAL CONTEMPORÂNEA NAS ELEIÇÕES MUNICIPAIS DE 2016
Authors: Baltar Claudia Siqueira , Baltar Ronaldo , Vieira Maria Fernanda Bleck 
Published: July 2020

Considerando o cenário contemporâneo das migrações internacionais, o presente trabalho tem por objetivo analisar a “visibilidade” dos migrantes internacionais “Sul-Sul” no cenário político local. O recorte empírico da análise são os programas político-partidários das eleições municipais de 2016, disponibilizados pelo Tribunal Superior Eleitoral (TSE) e os registros administrativos de entradas de imigrantes, do Sistema Nacional de Cadastramento de Registro de Estrangeiros (SINCRE), vinculado à Polícia Federal. Foram analisados diferentes grupos de municípios: capitais estaduais, municípios de fronteira, centros regionais e municípios da Região metropolitana de Londrina. As análises empreendidas ao longo do trabalho, por um lado, forneceram elementos importantes para a reflexão sobre os desafios inerentes à presença dos migrantes internacionais no cenário político local e, por outro, permitiram a definição de fatores relacionados à entrada desses migrantes na agenda político-eleitoral
Comparing Orphanges' Hope and Loneliness as Lifelong Learners in Tanjung Barat Orphanage South Jakarta
Authors: Anggraeni Anastasia Dewi 
Published: July 2020

This research aims to compare the loneliness and hope among orphans in the Tanjung Barat orphanage, South Jakarta. The research method used a descriptive qualitative with a case study method. Data collection techniques were interviews, observations, and filling in a simple questionnaire. The sample used 36 children of Tanjung Barat orphanage consisting of elementary school, junior high school and senior high school students. This was done on site and compared to the literature that had been previously established. Comparing loneliness and hope among orphans aimed to identify and find ways of mapping loneliness and hope among orphans who had been explored and investigated empirically, to find out the comparison and contrast with the mapping of loneliness and hope expressed among them, and to find examples of self-assessment to evaluate and encourage the mapping of their loneliness and expectations among them and present them to caregivers, parents and professionals. By comparing their loneliness and hopes they can actively engage in social interaction between themselves, others, and improve their personal, welfare and life skills.