bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entecavir vs Tenofovir in Hepatocellular Carcinoma Prevention in Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis
Authors: Cheung Ka Shing , Mak Lung Yi , Liu Sze Hang , Cheng Ho Ming , Seto Wai Kay , Yuen Man Fung , Lai Ching Lung 
Published: October 2020

INTRODUCTION:
Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line therapies for chronic hepatitis B (CHB) infection. Although both drugs reduce hepatocellular carcinoma (HCC) risk, their comparative effectiveness remains controversial. We aimed to determine whether TDF is superior to ETV in preventing HCC.

METHODS:
PubMed, Embase, and Cochrane Library from inception until June 9, 2020, were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Key terms included entecavir, tenofovir, and hepatocellular carcinoma. The adjusted hazard ratios (HRs) were pooled using a random effects model. Heterogeneity among studies was assessed by the Cochran Q test and I
2.

RESULTS:
Thirteen observational studies (4 of which were conference abstracts) were included with 85,008 patients with CHB (ETV: 56,346; TDF: 28,662). TDF was associated with a lower HCC risk (adjusted HR [aHR]: 0.81; 95% confidence interval [CI]: 0.67–0.99). This beneficial effect was present in cirrhotic patients (aHR: 0.73; 95% CI: 0.62–0.85) and retrospective cohort studies using electronic data sets (aHR: 0.63; 95% CI: 0.51–0.78). However, this beneficial effect did not reach statistical significance for noncirrhotic patients (aHR: 0.83, 95% CI: 0.51–1.35) and retrospective/prospective cohort studies using clinical records (aHR: 0.97; 95% CI: 0.80–1.18).

DISCUSSION:
TDF was associated with a lower HCC risk compared with ETV among patients with CHB, particularly cirrhotic patients. Further prospective large-scale studies with longer follow-up periods were required to identify specific subgroups that will benefit most from TDF.
Techniki tłumaczenia frazy תֵּבַת עֲצֵי־גֹפֶר i jej łacińskiego odpowiednika arca de lignis levigatis w czeskich i polskich przekładach biblijnych z okresu od XIV do XVI wieku
Authors: SIERADZKI Andrzej 
Published: October 2020

Przedmiotem analiz są sposoby przekładu fraz תֵּבַת עֲצֵי־גֹפֶר oraz arca de lignis levigatis w czeskich i polskich tekstach biblijnych z okresu od XIV do XVI wieku. Celem prowadzonych badań jest pokazanie na ile kształt leksykalny odpowiedników tych fraz we wspomnianych tłumaczeniach miał związek z wyborem podstawy tłumaczenia, z panującą w danym kręgu tradycją przekładową oraz z przyjmowanymi interpretacjami i objaśnieniami określonego miejsca w Biblii.
Prowadzone w artykule analizy pokazują, że autorzy wszystkich czeskich przekładów biblijnych unikają dosłownego tłumaczenia rzeczownika tebh i jego łacińskiego odpowiednika arca. Tak translatorzy katoliccy, jak i protestanccy regularnie oddają go przez rzeczownik koráb. Taki sposób przekładu przyjmują też, wzorując się na Czechach, katolickie biblie polskie. Stan obserwowany w badanych tekstach dowodzi, że decyzje translatorskie były motywowane nie znaczeniem rzeczownika z podstawy hebrajskiej czy łacińskiej, ale związane były z możliwymi ujęciami arki Noego w pismach teologicznych czy nawet utrwalonych w ogólnie pojętej kulturze chrześcijańskiej.
Inne rozwiązania na gruncie polskim przyjmują protestanckie tłumaczenia z języków oryginału, w których człon konstytutywny frazy stanowią rzeczowniki archa i skrzynia, bezpośrednio nawiązujące do znaczenia rzeczownika z podstawy tłumaczenia.
IFCC Interim Guidelines on Biochemical/Hematological Monitoring of COVID-19 Patients
Authors: Thompson Simon , Bohn Mary Kathryn , Mancini Nicasio , Loh Tze Ping , Wang Cheng-Bin , Grimmler Matthias , Yuen Kwok-Yung , Mueller Robert , Koch David , Sethi Sunil , Rawlinson William D. , Clementi Massimo , Erasmus Rajiv , Leportier Marc , Kwon Gye Cheol , Menezes María Elizabeth , Patru Maria-Magdalena , Gramegna Maurizio , Singh Krishna , Najjar Osama , Ferrari Maurizio , Lippi Giuseppe , Adeli Khosrow , Horvath Andrea R. 
Published: October 2020

Abstract
Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. While these tests are already well established in most clinical laboratories, there is still debate regarding their clinical value in the management of COVID-19, particularly in pediatrics, as well as the value of composite clinical risk scores in COVID-19 prognostication. This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. These evidence-based recommendations will provide practical guidance to clinical laboratories worldwide, underscoring the contribution of biochemical and hematological testing to our collective pandemic response.
Pain management programmes via video conferencing: a rapid review
Authors: Walumbe Jackie , Belton Joletta , Denneny Diarmuid 
Published: October 2020

Abstract

Objectives
During the current COVID-19 pandemic, healthcare has been transformed by the rapid switch from in person care to use of remote consulting, including video conferencing technology. Whilst much has been published on one-to-one video consultations, little literature exists on use of this technology to facilitate group interventions. Group pain management programmes are a core treatment provided by many pain services. This rapid review aimed to identify the extent of use of video conferencing technology for delivery of group pain management programmes and provide an overview of its use.

Methods
A rapid review of the literature published up to April 2020 (PubMed, PsycINFO and PEDro) was performed. The search string consisted of three domains: pain/CP (MeSH term) AND Peer group[MeSH] AND Videoconferencing[MeSH]/Telemedicine[MeSH]/Remote Consultation[MeSH]. The studies were of poor methodological quality and study design, and interventions and chronic pain conditions were varied.

Results
Literature searching yielded three eligible papers for this review. All studies had low methodological quality and risk of bias. Heterogeneity and variability in outcome reporting did not allow any pooling of data. The results demonstrated that videoconferencing for delivery of group programmes is possible, yet there is little extant literature on how to develop, deliver and measure outcomes of such programmes.

Conclusions
This review demonstrates that there is little evidence to support or guide the use of synchronous videoconferencing to deliver pain management programmes. We present issues to consider, informed by this review and our experience, when implementing video conferencing. Study quality of existing work is variable, and extensive future research is necessary.
Religionspädagogik und

empowerment.
Authors: Bucher Georg 
Published: October 2020

Zusammenfassung
Religionspädagogik ist ein immerwährendes, interdisziplinäres Gespräch, das seinen Ausgangspunkt bei Fragen religiösen Lehrens und Lernens nimmt. Der Artikel führt im Zusammenhang dieses Verständnisses der Disziplin den Begriff empowerment als Gesprächsmedium ein. Dadurch kommen neue Gesprächspartner mit an den Tisch (Gemeindepsychologie, Theorie der Sozialen Arbeit, Förderpädagogik, Kritische Pädagogik), zudem ergeben sich veränderte Fragestellungen und Forschungsperspektiven. Diese werden für das systematische, das historische und das empirische Forschungsfeld exemplarisch dargelegt.
Zur Einschätzung von instruktionalen Erklärungen im Religionsunterricht – eine empirische Untersuchung im Rahmen des Projekts FALKE
Authors: Fricke Michael , Murmann Renate 
Published: October 2020

Zusammenfassung
Das Projekt FALKE-Religion untersucht, wie instruktionale Erklärungen zu drei Themenbereichen (biblische Schöpfungstexte, Kreationismus und Perspektivenwechsel) von Schüler/innen, Lehramtsstudierenden, Religionslehrkräften und an der Universität lehrenden Religionsdidaktiker/innen in ihrer Qualität eingeschätzt werden und welche Kriterien dabei zentral sind (N= 317). FALKE-R ist Teil des Großprojektes FALKE, an dem sich 13 Disziplinen beteiligen (N=3.116).
Determination of 234U and 238U in seawater samples by alpha spectrometry after concentration of U(VI) onto hydrotalcite and co-precipitation with LaF3
Authors: Suc N. V. , Bich T. T. 
Published: October 2020

Summary
This paper presents a simple and accurate method for determination of uranium isotopes (234U and 238U) in seawater samples using alpha spectrometry. Uranium is pre-concentrated from seawater samples via adsorption on hydrotalcite at pH 6.5. The absorbent is dissolved into 50 ml of 8M HNO3; then filtered through a Dowex-1 column. U(VI) in the elution solution is reduced to U(IV) using zinc metal in 4M solution of HCl and then co-precipitated with LaF3. The chemical separation efficiency is found to be 97.12±2.68%, eliminating the need of using 232U tracer in other published methods. This method is validated via comparison with results obtained using inductively coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis (NAA) for three seawater samples.
The relationship between the skill-challenge balance, game expertise, flow and the urge to keep playing complex mobile games
Authors: Larche Chanel J. , Dixon Mike J. 
Published: October 2020

AbstractBackground and aimsInterest surrounding the relationship between flow and problematic gameplay has surged. An important antecedent of flow in the context of video-gaming is the skill-challenge balance, but researchers have only manipulated this balance by changing speed of play. The current research seeks to examine the skill-challenge balance and flow in a mobile game in which challenge is increased via the complexity of puzzles. We predicted games like Candy-Crush would more strongly support a model of flow in which the greatest flow would be experienced by more skilled players and that high flow games would induce the most urge to continue play.MethodsWe had 60 Candy-Crush players play games near their level standing (maximal skill-challenge balance), or games that were too easy or too hard. Perceived skill, challenge, flow, and urge to continue gameplay were measured after each game.ResultsPlayers felt the highest degree of skill-challenge balance when playing games around their level standing. Easy games produced the least flow, while both regular and hard games produced comparable flow despite hard games being far more challenging and frustrating. The findings support models of flow positing those with highest perceived skill will experience greater flow. Finally, flow and arousal combine to increase urge to keep playing.Discussion and conclusionsOur findings suggest those with high perceived skill will experience deep, immersive flow which motivates players to keep playing.
A paracetamolterápia és az idült májbetegség tragikus következményei
Authors: Lajtai Anikó , Lakatos Ágnes , Kuzma Mónika , Mayer Mátyás , Miseta Attila 
Published: October 2020

Absztrakt:
Az őszi és téli meghűléses időszakban sokan vásárolnak különböző, vény nélkül
kapható, megfázás elleni készítményeket, ezen belül is nagy számban paracetamol-
(más néven acetaminofén-) tartalmú szereket. A paracetamol különböző típusú
fájdalmak (fejfájás, migrén, meghűlés-láz okozta fájdalom, fogfájás,
menstruációs fájdalom stb.) enyhítésére szolgáló, igen népszerű, a nemopioid
típusú analgetikumok közé sorolható hatóanyag, amely többek között tabletta, kúp
és oldat formájában is elérhető a gyógyszertárakban. Magyarországon 2020-ban 86,
törzskönyvezett paracetamoltartalmú készítmény van forgalomban. A paracetamol
alkalmazása biztonságos és hatékony, amennyiben az előírásnak megfelelően
használják. Közleményünkben három olyan esetet mutatunk be, amelyben a beteg
halála összefüggésbe hozható a paracetamol alkalmazásával. Mindhárom, krónikus
alkoholizmusban szenvedő beteg (34, 42 és 51 évesek) rövid idővel a kórházba
kerülés után elhunyt. Vizsgálataink során három betegből származó, összesen
kilenc szérumminta került feldolgozásra. A paracetamolnak és metabolitjainak
együttes meghatározása enzimatikus módszerrel (Roche assay) történt, míg a
paracetamol specifikus mérésére tandem-tömegspektrométerrel kapcsolt
szuperkritikus folyadékkromatográfot (SFC–MS/MS) alkalmaztunk. Enzimatikus
meghatározással mindegyik mintában terápiás koncentrációt mutattunk ki.
SFC–MS/MS módszerrel történt meghatározás esetén egy betegtől származó négy
mintában a terápiás tartománynál alacsonyabb paracetamolkoncentrációkat mértünk.
A paracetamolterápia alkalmazása krónikus alkoholizmusban szenvedő betegek
esetén fokozott kockázatot jelent. A klinikai toxikológiai gyakorlatban a
paracetamol meghatározására használt enzimatikus módszer eredményét a máj- és
vesefunkciós paraméterekkel együttesen szükséges értékelni, mert krónikus
alkoholizmusban szenvedő betegek esetén az enzimatikus módszerrel kapott
terápiás tartományba eső koncentráció nem zárja ki a paracetamoltoxicitást. Orv
Hetil. 2020; 161(40): 1720–1723.
OPPORTUNITIES FOR IMPROVING THE COMPETITIVENESS OF RAIL FREIGHT TRANSPORTATION ALONG THE TRANSPORT CORRIDORS OF THE RUSSIAN FEDERATION
Authors: Kuzmin P. S. 
Published: October 2020

The greatest prospects associated with transnational rail freight are determined by the use of containers. In Russian publications, the development of containerized cargo transportation is mainly considered by analyzing the general laws of functioning of international transport corridors. At the same time, aspects affecting infrastructure diagnostics and analysis of the throughput capacity of sections of the railway network are not considered.The purpose of the study was to identify the characteristics of freight flows in the direction of the EU—EAEU—PRC, to identify infrastructure barriers that slow down the acceleration and increase in the volume of container railway freight transportation, as well as to develop a set of measures aimed at improving the competitiveness of container railway freight transportation along the transport corridors of the Russian Federation.In the course of the study, infrastructural diagnostics was carried out, which revealed a number of barriers that did not allow realizing the growth potential of transit container cargo transportation.To remove infrastructure barriers, it is necessary to implement a number of measures, the key of which are measures to increase the capacity of infrastructure at border crossings, increase the speed of trains along the railway networks of JSCo RZD, develop terminal and logistics centers that provide a wide range of services for consignors and consignees.The development of container rail freight is a strategically important area for the Russian Federation. The well-coordinated work of Russian Railways with private investors and the state in the framework of expanding and modernizing the terminal infrastructure, as well as increasing intermodal interactions, is able to overcome the existing infrastructure barriers and ensure the growth of container transit in the required volumes.
DEVELOPMENT OF FORMS OF INTERACTION BETWEEN UNIVERSITIES AND THE BUSINESS COMMUNITY IN THE DIGITAL ECONOMY
Authors: Kulyasova E. V. , Trifonov P. V. 
Published: October 2020

The article is devoted to the construction of a model of interaction of economic entities using the method of project work of participants in the system “enterprise/employer-University – state” on the technological platform of the meta-University in the conditions of digitalization of the economy, which allows to increase the synergy effect of the interaction of the main institutional participants.In the context of the impact of digitalization processes on the transformation of behavioral models within the existing economic relations in the VUCA world, new requirements and ways of interaction of subjects of the triple helix model are considered. The article analyzes the main existing and prospective forms of cooperation between universities and business structures. The detailed description of barriers and difficulties on the way of digitalization of enterprises and scientific organizations is given.For employees of scientific and commercial enterprises in the conditions of digitalization and General increased uncertainty, recommendations are formulated for the choice of a behavior model that adapts their professional identity based on the principles of a proactive position and knowledge and skills at the intersection of different technological directions.Under the conditions of variability and uncertainty of the environment, a scientific problem has been identified, there is a high interest in collaboration between universities and businesses, but there is no mechanism that allows this interaction to be carried out with a high degree of efficiency.A set of mechanisms that help reduce the level of uncertainty is proposed, as well as a project method of interaction within the framework of the digital meta-University technology platform model is described.The article provides recommendations for the full implementation of human capital in the new technological conditions of economic and social development, in the so-called VUCA-world, which is characterized by the lack of a developed digital infrastructure, as well as a high level of transaction costs.A new approach is proposed, based on which participants will interact on the basis of shared access to information and digital resources and the ability to combine the development of innovative projects and training of personnel necessary to unite the University, enterprises and scientific organizations to reduce transaction, fixed and variable costs of participants in the process.
Dynamic construction of the educational process in an integrated learning system
Authors: Grinberg G. M. 
Published: October 2020

The main task of the system of Higher Professional Education is to satisfy requirements of a labor market with specialists of the needed profile and with demanded level of the acquirements. In the article it is justified, thatthe pedagogical conditionsof application of the dynamic constructiontechnology of the educational processin the paradigm of the integrated educational system facilitate the task solution of improving of the educationquality.
Association between Body Mass Index (BMI) and Severity of Coronary Artery Disease in Young Onset Acute Coronary Syndrome (ACS)
Authors: Moniruzzaman Dr. Md. , Koli Anar , Ferdous Dr. Jannatul , Bagchi Dr. Sushil Kumar , Malik Dr. FazilaTun-Nesa , Sakib Dr. Annaz Mus , Nesa Malik Dr. FazilaTun- 
Published: October 2020

Background:
A high body mass index (BMI) is seems to be associated with an increased incidence of coronary artery disease. If the affected person is young, the consequences are more tragic. There are variable information on the relation of incidence and severity of coronary artery disease in high BMI populations. We have examined the association between BMI and severity of coronary artery disease in young onset Acute Coronary Syndrome (ACS).
Methods:
In this prospective observational study a total number of 150 patients, aged ≤45 years presented with acute coronary syndrome were enrolled to analyze association between Body Mass Index (BMI) and severity of coronary artery disease.
Results:
The mean BMI in male was 24.6±3.6 and the mean BMI in female was 25.4±3.3. Among the 150 patients, 2(1.3%) was underweight, 78(52%) was normal, 60(40%) was overweight & 10(6.7%) was obese. All underweighted patients were diagnosed as STEMI. Among the normal BMI patients, 18(23.1%) had UA, 12(15.4%) had NSTEMI & 48 (61.5%) had STEMI. Among the overweight patients, 23(38.3%) had UA, 9(15%) had NSTEMI & 28(46.7%) had STEMI. And among the obese patients, 4(40%) had UA, 1 (10%) had NSTEMI & 5(50%) had STEMI. Considering involving coronary artery, left main coronary artery involvement was 0(0%), 6 (7.7%), 5 (8.3%) & 0(0%) in underweight, normal, overweight & obese patients respectively. Left anterior descending coronary artery involvement was 2(100%), 54 (69%), 45 (75%) & 7 (70%) in underweight, normal, overweight & obese patients respectively. Left circumflex coronary artery involvement was 1(50%), 33 (42%), 25 (41.7%) & 1 (9%) in underweight, normal, overweight & obese patients respectively. And right coronary artery involvement was 1(50%), 35 (44.9%), 31 (51.7%) & 5 (50%) in underweight, normal, overweight & obese patients respectively. In underweight patients 1(50%) had SVD and 1 (50%) had TVD. In normal BMI patients 40 (51.3%) had SVD, 11(14.1%) had DVD and 19 (24.4%) had TVD. In overweight patients 27 (45%) had SVD, 15 (25%) had DVD and 13 (21.7%) had TVD. And in obese patients 5 (50%) had SVD, 3(30%) had DVD and 0 (0%) had TVD. In all BMI group SVD was more common.
Conclusion:
There is no statistically significant differences in severity of coronary artery in respect to body mass index (BMI), in patients presented with acute coronary syndrome.
Correlation of Epidermal Fibroblast Growth Factor and Clinical Improvement of Asthma in Children after Zinc Supplementation
Authors: Setyoningrum Retno Asih , Endaryanto Anang , Ugrasena I Dewa Gede 
Published: October 2020

Background: Background The presence of remodeling process on the pathogenesis of asthma that involves some growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF) causes the chronicity of the disease. The role of zinc on the pathogenesis of asthma is being widely investigated. This study aimed to analyze the correlation between EGF and FGF2 and clinical improvement of asthma after zinc supplementation.Methods: A quasi-experimental study was conducted in Outpatient Clinic Dr. Soetomo Hospital. The samples were persistent asthma patients from 6-15 years old who received controller therapy. The samples were divided into 2 groups, those who received zinc supplementation as the intervention group, and who received pacebo as the control. EGF and FGF2 plasma level of both groups were measured, and clinical improvement was evaluated with Childhood Asthma Control Test (C-ACT).Results: There were 11 patients who received zinc supplementation and 12 patients in the control group. There was a significant difference (p = 0.000) on the increase of EGF level in the intervention group (55.59 ± 6.48) than the control (5.35 ± 5.55). There was a significant difference (p = 0.000) on the increase of the FGF2 level in the intervention group (6.37 ± 1.41) than the control (0.72 ± 0.48). The increase of EGF (r = 0.592; p = 0.003) and FGF2 (r = 0.607; p = 0.002) would be followed by the increase of C-ACT scores.Conclusion: Zinc supplementation increase EGF and FGF2 levels. This improvement is correlated with clinical improvement of patients.