bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metaplectic geometrical optics for modeling caustics in uniform and non-uniform media
Authors: Lopez N A , Dodin I Y 
Published: December 2020

Abstract
As an approximate theory that is highly regarded for its computational efficiency, geometrical optics (GO) is widely used for modeling waves in various areas of physics. However, GO fails at caustics, which significantly limits its applicability. A new framework, called metaplectic geometrical optics (MGO), has recently been developed that allows caustics of certain types to be modeled accurately within the GO framework. Here, we extend MGO to the most general case. To illustrate our new theory, we also apply it to several sample problems, including calculations of two-dimensional wavefields near fold and cusp caustics. In contrast with traditional GO solutions, the corresponding MGO solutions are finite everywhere and approximate the true wavefield well near these caustics.
Precipitation behavior of yttrium-rich nano-phases in AlCoCrFeNi2.1Yx high-entropy alloy
Authors: Sha Minghong , Zhou Yanwen , Wang Ning , Yu Dechuan , Wang Zhongjun , Ai Xingang , Wang Hongbin , Shen Minggang , Li Shengli 
Published: December 2020

Abstract
In this paper, rare earth element yttrium (Y) was selected to be doped into AlCoCrFeNi2.1Y
x (x = 0, 0.1%, 0.3%, 0.5%, and 1.0%) high-entropy alloy in order to refine grain and increase yielding strength. The precipitation behavior of the Y-rich nano-phases in the face centered cubic (FCC (L12)) phase and the body centered cubic (BCC (B2)) phase was investigated by x-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. Refined crystal grains were observed due to the high-density precipitation. The nano-phase within the BCC(B2) phase was (Al-Ni-Y)-rich phase and single cubic (SC) structure. The nano-phase formed within the FCC (L12) phase was (Fe-Co-Cr-Y)-rich phase and FCC structure. Fine (Al-Ni-Y)-rich nano-particles were formed due to the addition of Y and the amount of the nano-phase increased with increasing Y content. The adoption of Y promoted dispersed precipitation of (Al-Ni-Y)-rich nano-phase under deformation. The more Y content, the more nano-precipitates. When Y =1.0 at.%, the lamellar structure was transformed into bamboo-like structure in the BCC phase due to the segregation of Y. Double yielding phenomenon occurred during the compression deformation of the AlCoCrFeNi2.1Y
x
alloys (when x ≥ 0.5 at.%) and caused an increase of yielding strength by 40%. It was since the barrier effect of both the (Al-Ni-Y)-rich nano-precipitation and the (Fe-Co-Cr-Y)-rich nano-phases on the dislocations within grains and grain boundaries led to the second yielding. With the further increase of Y content, the lamellar BCC phase was separated from the bamboo-like BCC phase owing to the super-saturated precipitation and segregation of Y at the solidification front of B2 phase, leading to a degradation of mechanical properties.
Chaotic transients and hysteresis in an α
2 dynamo model
Authors: Oliveira Dalton N , Rempel Erico L , Chertovskih Roman , Karak Bidya B 
Published: December 2020

Abstract
The presence of chaotic transients in a nonlinear dynamo is investigated through numerical simulations of the 3D magnetohydrodynamic equations. By using the kinetic helicity of the flow as a control parameter, a hysteretic blowout bifurcation is conjectured to be responsible for the transition to dynamo, leading to a sudden increase in the magnetic energy of the attractor. This high-energy hydromagnetic attractor is suddenly destroyed in a boundary crisis when the helicity is decreased. Both the blowout bifurcation and the boundary crisis generate long chaotic transients that are due, respectively, to a chaotic saddle and a relative chaotic attractor.
Navigating uncharted waters: Developing a standardized approach for evaluating and implementing biosimilar products at a comprehensive cancer center
Authors: Villanueva Mara N , Davis Jennifer E , Sobocinski Stacey M 
Published: December 2020

Abstract

Purpose
The processes for formulary implementation and electronic health record (EHR) integration of biosimilar products at a comprehensive cancer center are described. Implications for research protocols are also discussed.

Summary
The existing literature focuses on practical considerations for formulary addition of biosimilar products, but there is a lack of guidance on how to implement the change, particularly within the EHR. Before building the ordering tools for biosimilars, the clinical and informatics teams should determine the role of biosimilars at the institution, identify drug-specific product characteristics that affect medication build, and characterize implications of future formulary changes or drug shortages. Leveraging an orderable record provides the ability to include logic that maps to multiple products and also allows for future implementation of changes within the medication record rather than requiring “swaps” at the treatment protocol level. The institutional review board should coordinate changes in affected research protocols and consent forms and work with principal investigators to amend protocols when necessary. Pharmacy leaders should develop processes to oversee inventory during the transition period and minimize the risk of errors.

Conclusion
The development of a standardized approach for evaluating and implementing biosimilar products improves efficiency and collaboration among the various team members responsible for the products’ integration into existing workflows, including implications for clinical research. Implementing biosimilars for agents used to treat cancer will pose new challenges and require additional considerations. Partial implementation of biosimilars continues to pose multiple challenges in the provision of patient care.
Biosimilar formulary placement in Medicare Part D prescription drug plans: A case study of infliximab
Authors: Socal Mariana P , Ezebilo Ijeamaka , Bai Ge , Anderson Gerard F 
Published: December 2020

Abstract

Purpose
Biosimilars can generate competition and provide cost savings over reference biologics for the Medicare program and beneficiaries. The extent to which these benefits can be realized in the Medicare Part D program depends on how biosimilars and biologics are placed in the formulary. We conducted a study to examine Medicare formulary placement of the first biologic to have 2 biosimilars on the market—infliximab and its biosimilars infliximab-dyyb and infliximab-abda.

Methods
All standalone and Medicare Advantage (MA) prescription drug plans (PDPs) offered in Medicare Part D were examined between September 2016 (ie, at the end of the last quarter before the launch of the first infliximab biosimilar) and September 2018, at which time a second biosimilar had been on the market for about 14 months. When PDPs covered both the reference biologic and a biosimilar, we compared the cost-sharing tier and the frequency of prior authorization and step therapy requirements for each drug.

Results
Nearly all PDPs covered infliximab throughout the study period. By September 2018, 31.7% of MA plans and 14.9% of standalone PDPs were covering a biosimilar on the market. Nearly all plans that covered a biosimilar also covered the reference product. Most plans (98% of standalone PDPs and 89% of MA plans) had placed prior authorization restrictions on both the biologic and the biosimilar. All plans covering both products placed them in the same cost-sharing tier. No plan required step therapy for either product.

Conclusion
Formulary placement of infliximab biologic and biosimilars in Medicare Part D is not optimized to generate cost savings for the Medicare program and beneficiaries, whose cost sharing is often based on the drug’s list price. The Medicare program should provide incentives for PDPs to expand biosimilar coverage.
13 Ways of Looking at Reproductive Lives
Authors: Weingarten Karen 
Published: December 2020

Abstract
This review essay places The Myth of the Perfect Pregnancy (2019), which historicizes miscarriage, in conversation with What God is Honored Here? (2019), a collection of essays by Native women and women of color about miscarriage and infant loss, to show how the history and current experience of miscarriage is complicated by the cultural forces that tell us how to feel about our reproductive experiences. However, it also argues that even if we are to contextualize miscarriage as a common, normal part of reproduction, as Lara Freidenfelds argues we should do, there is still an imperative to understand how, for Native women and women of color, the experience of miscarriage and infant loss can often be shaped by the racism of medical institutions and by a historical exclusion from health care that values their pregnancies and reproductive bodies.
Postsecular Style
Authors: Stanley Kate 
Published: December 2020

Abstract
In Culture and Redemption (2007), Tracy Fessenden argues that the development of postsecular critique requires a more thorough reckoning with the secular assumptions that so durably structure the categories and grammars of critical thought. As Peter Coviello and Jared Hickman have since elaborated, such a reckoning entails the radical reinvention of postsecularism’s critical style. But what might these more pointedly situated and styled voices of postsecular critique sound like? Recent books of Americanist criticism by Coviello, Lindsay V. Reckson, and Phillip Maciak suggest new possibilities by coupling alternate cultural histories of the nineteenth century with instructive experiments in critical style. Each of these studies begins with a similar conviction: that stepping outside the immanent frame of secularism is impossible. Yet Coviello, Reckson, and Maciak all work to locate and create meaningful cracks in this frame. By flagging the hegemonic secular presumptions inherent to their own critical authority, by thinking, feeling, and writing from an unusually intimate proximity to their subjects, these three critics model how others might similarly evolve and enliven the postsecular approach.
Snapshot of Social Work in China: Outcomes of Stakeholder Competition
Authors: Yi-Bing Xu , Quan-Cai Li , Meng Cui 
Published: December 2020

AbstractSince its introduction from the West, social work has unprecedentedly developed in China in recent decades. Accordingly, existing definitions of social work became outdated quickly inevitably. Indigenisation offers a useful perspective for understanding the development of social work in the rapidly changing context of China. However, indigenisation is often regarded as a linear and unidirectional process of knowledge transfer and adoption from the West to third world countries, which easily results in local dynamics getting ignored. This article views indigenisation as the result of competition amongst different local stakeholders. By discussing social work in China presently and examining the performance of different stakeholders, we argue that Chinese social work differs from social work in the West to some extent, especially in terms of its professional value, which has been challenged. Finally, the article highlights the implications of China’s experience with social work for the international community.
Multidimensional inflammatory and immunological endotypes of idiopathic focal segmental glomerulosclerosis and their association with treatment outcomes
Authors: Roca Neus , Madrid Alvaro , Lopez Mercedes , Fraga Gloria , Jatem Elias , Gonzalez Jorge , Martinez Cristina , Segarra Alfons 
Published: December 2020

Abstract

Objectives
Idiopathic focal segmental glomerulosclerosis (FSGS) has been linked to immunological and inflammatory response dysregulations. The aim of this study was to find endotypes of FSGS patients using a cluster (CL) analysis based on inflammatory and immunological variables, and to analyse whether a certain endotype is associated with response to treatment with corticosteroids.

Methods
This prospective observational study included patients with idiopathic FSGS diagnosed by kidney biopsy. Serum levels of soluble interleukin (IL)-1 receptor, tumoural necrosis factor alpha, Interferon gamma (IFNγ), IL-6, IL-17, IL-12, IL-23, IL-13, IL-4, IL-5, IL-6, haemopexin (Hx), haptoglobin (Hgl), soluble urokinase-type plasminogen activator receptor (suPAR) and urinary CD80 (uCD80) were measured with enzyme-linked immunosorbent assay or nephelometry. T-helper lymphocyte populations and T-regulatory lymphocytes were analysed by flow cytometry. A factorial analysis followed by a k-means CL analysis was performed.

Results
A total of 79 FSGS patients were included. Three CLs were identified. CL1 (27.8%) included IL-12, IL-17, IL-23 and a T helper 17 (Th17) pattern. CL2 (20.2%) included IL-4, IL-5, IL-13, immunoglobulin E and Th2 pattern. CL3 (51.8%) included IL-6, Hx, Hgl, suPAR and uCD80. There were no differences in age, gender, kidney function, albumin or proteinuria among CLs. About 42/79 patients (53.1%) showed cortico-resistance. The prevalence of cortico-resistance was significantly lower in CL2 (4/16, 25%) than in CL1 (16/26, 72.7%) and CL3 (22/41, 53.7%) (P = 0.018), with no significant differences between CLs 1 and 3 (P = 0.14).

Conclusions
Patients with FSGS and indistinguishable clinical presentation at diagnosis were classified in three distinct CLs according to predominant Th17, Th2 and acute inflammatory responses that display differences in clinical response to treatment with corticosteroids.
Prenatal lead exposure and cord blood DNA methylation in PROGRESS: an epigenome-wide association study
Authors: Heiss Jonathan A , Téllez-Rojo Martha M , Estrada-Gutiérrez Guadalupe , Schnaas Lourdes , Amarasiriwardena Chitra , Baccarelli Andrea A , Wright Robert O , Just Allan C 
Published: December 2020

AbstractThe effects of prenatal lead exposure on child development include impaired growth and cognitive function. DNA methylation might be involved in the underlying mechanisms and previous epigenome-wide association studies reported associations between lead exposure during pregnancy and cord blood methylation levels. However, it is unclear during which developmental stage lead exposure is most harmful. Cord blood methylation levels were assayed in 420 children from a Mexican pre-birth cohort using the Illumina Infinium MethylationEPIC microarray. Lead concentrations were measured in umbilical cord blood as well as in blood samples from the mothers collected at 2nd and 3rd trimester and delivery using inductively coupled plasma-mass spectrometry. In addition, maternal bone lead levels were measured in tibia and patella using X-ray fluorescence. Comprehensive quality control and preprocessing of microarray data was followed by an unbiased restriction to methylation sites with substantial variance. Methylation levels at 202 111 cytosine-phosphate-guanine sites were regressed on each exposure adjusting for child sex, leukocyte composition, batch variables, gestational age, birthweight-for-gestational-age, maternal age, maternal education and mode of delivery. We find no association between prenatal lead exposure and cord blood methylation. This null result is strengthened by a sensitivity analysis showing that in the same dataset known biomarkers for birthweight-for-gestational-age can be recovered and the fact that phenotypic associations with lead exposure have been described in the same cohort.
Inferior ST-elevation myocardial infarction managed with a pharmacoinvasive strategy and conservative management of delayed atrioventricular block: classical case report
Authors: John Thadathilankal-Jess , Kyriakakis Charles , Zachariah Don , Doubell Anton 
Published: December 2020

Abstract

Background
The 2017 ESC guideline on patients with ST-segment elevation myocardial infarction (STEMI) provides guidance regarding the optimal management of these patients. Transient atrioventricular (AV) block is a relatively common complication of inferior STEMI and its management is also addressed in the guidelines.

Case summary
A 64-year-old gentleman with multiple cardiovascular risk factors presented to the emergency department with a history of ischaemic type chest pain and evidence of inferior ST-segment elevation on his electrocardiogram (ECG). First-degree AV block was noted on his initial ECG. He was given thrombolytic therapy as part of a pharmacoinvasive strategy of reperfusion. He, however, failed fibrinolytic therapy, and emergency angiography revealed critical disease of the right coronary artery which was successfully stented. Subsequent to reperfusion, he developed complete AV block without evidence of re-infarction, which was managed conservatively with successful resolution of the block after 7 days of expectant management with temporary transvenous pacing.

Discussion
We highlight some of the important management principles from the ESC guideline of STEMI including timing and the management of AV block in these patients. In addition, we highlight the role of a pharmacoinvasive strategy for reperfusion where timeous primary percutaneous coronary intervention cannot be performed. The usefulness of such a strategy within the COVID-19 era is also emphasized.
Lipoproteins in chronic kidney disease: from bench to bedside
Authors: Speer Thimoteus , Ridker Paul M , von Eckardstein Arnold , Schunk Stefan J , Fliser Danilo 
Published: December 2020

Abstract
Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients exhibit a specific lipoprotein pattern termed ‘uraemic dyslipidaemia’, which is characterized by rather normal low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, and high triglyceride plasma levels. All three lipoprotein classes are involved in the pathogenesis of CKD-associated cardiovascular diseases (CVDs). Uraemia leads to several modifications of the structure of lipoproteins such as changes of the proteome and the lipidome, post-translational protein modifications (e.g. carbamylation) and accumulation of small-molecular substances within the lipoprotein moieties, which affect their functionality. Lipoproteins from CKD patients interfere with lipid transport and promote inflammation, oxidative stress, endothelial dysfunction as well as other features of atherogenesis, thus contributing to the development of CKD-associated CVD. While, lipid-modifying therapies play an important role in the management of CKD patients, their efficacy is modulated by kidney function. Novel therapeutic agents to prevent the adverse remodelling of lipoproteins in CKD and to improve their functional properties are highly desirable and partially under development.
Lessons for the global primary care response to COVID-19: a rapid review of evidence from past epidemics
Authors: Desborough Jane , Dykgraaf Sally Hall , Phillips Christine , Wright Michael , Maddox Raglan , Davis Stephanie , Kidd Michael 
Published: December 2020

AbstractBackgroundCOVID-19 is the fifth and most significant infectious disease epidemic this century. Primary health care providers, which include those working in primary care and public health roles, have critical responsibilities in the management of health emergencies.ObjectiveTo synthesize accounts of primary care lessons learnt from past epidemics and their relevance to COVID-19.MethodsWe conducted a review of lessons learnt from previous infectious disease epidemics for primary care, and their relevance to COVID-19. We searched PubMed/MEDLINE, PROQUEST and Google Scholar, hand-searched reference lists of included studies, and included research identified through professional contacts.ResultsOf 173 publications identified, 31 publications describing experiences of four epidemics in 11 countries were included. Synthesis of findings identified six key lessons: (i) improve collaboration, communication and integration between public health and primary care; (ii) strengthen the primary health care system; (iii) provide consistent, coordinated and reliable information emanating from a trusted source; (iv) define the role of primary care during pandemics; (v) protect the primary care workforce and the community and (vi) evaluate the effectiveness of interventions.ConclusionsEvidence highlights distinct challenges to integrating and supporting primary care in response to infectious disease epidemics that have persisted over time, emerging again during COVID-19. These insights provide an opportunity for strengthening, and improved preparedness, that cannot be ignored in a world where the frequency, virility and global reach of infectious disease outbreaks are increasing. It is not too soon to plan for the next pandemic, which may already be on the horizon.
Amendments to the Argentine Trademark Law: Initial Impact
Authors: Quadrio Iris V , O’Donnell Carol A 
Published: December 2020

Abstract
This paper examines the principal changes to the Argentine Trademark Law in 2018. The aim of these amendments was to reduce bureaucracy and simplify administrative procedures in a vast diversity of areas besides intellectual property, such as corporate, finance, insurance and labor matters, among others. With respect to intellectual property, however, some of the changes seem to be substantive and not merely procedural. The purpose of this article is to analyze the changes to the Argentine Trademark Law and provide a practical reference guide in relation to trademark protection in Argentina. The authors discuss how the system for resolving oppositions has been simplified, reducing time and costs to obtain registrations. In addition, the authors provide a comparative review of some of the judicial decisions ruled on the merit of oppositions and those adopted by the National Institute of Industrial Property in 2020. Based on this comparative case law and the analysis of the amendments to the new law, the authors share their views on the implementation of the changes and their application in practice, which may serve as a starting point for those interested in registering their trademarks in Argentina. They conclude that the modifications to the Argentine Trademark Law are positive and aim to bring the Argentine system in line with international standards.