bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and Molecular Screening of Nasal S. aureus from Adult Hospitalized Patients for Methicillin- and Vancomycin-resistance
Authors: Al-Tamimi Mohammad , Himsawi Nisreen , Abu-Raideh Jumana , Khasawneh Ashraf I. , jazar Deaa Abu , Al-jawaldeh Hussam , Hawamdeh Hasan 
Published: January 2020

Introduction:
Nasal carriers of Staphylococcus aureus are common and play an important
role in the transmission of infections. The aim of this study is a phenotypic and molecular investigation
of nasal methicillin- and vancomycin-resistant S. aureus in hospitalized patients.

Methods:
202 nasal swabs were collected from patients at Prince Hamzah Hospital, Jordan,
through 2016-2017. Swabs were processed according to standard microbiological procedures to
isolate Staphylococci. Antibiotic susceptibility testing was performed using disk diffusion, E-test,
microdilution and Vitek 2. Methicillin resistance was confirmed by testing for the mecA gene,
while vancomycin resistance was screened by testing for the vanA and vanB genes.

Results:
The mean age of participants was 50.17±18.18 years and 59.4% were females. Nasal
Staphylococci was isolated in 64/202 (31.7%), S. aureus was isolated from 33 samples (16.3%),
MRSA was isolated from 13 samples (6.4%) and constitutive Macrolide-lincosamidestreptogramin
B (MLSB) was isolated from 12 samples (5.9%). All MRSA isolates harbored the
mecA gene. All isolates were sensitive to vancomycin using E-test and the microdilution test and
were negative for the vanA and vanB genes. The highest resistance rate was observed for benzylpenicillin
(>90%), while the lowest resistance rate was for tobramycin (<5%) among all isolates.
Nasal Staphylococci, S. aureus and MRSA colonization significantly correlate with increased
number of family members and previous hospitalization (P<0.05), while nasal S. aureus
significantly correlates with a history of skin infection (P=0.003).

Conclusions:
Nasal colonization by mecA-mediated MRSA is common among hospitalized patients,
while vanA- and vanB-mediated vancomycin resistance was not detected in any nasal isolates.
Effects of Simvastatin on the Metabolism of Fatty Acids in Combined Secondary Prevention of Coronary Heart Disease: Dosage and Gender Differences between the Effects
Authors: Kotlovskiy Mikhail Y. , Udut Elena V. , Kairov Gaisa T. , Fisenko Vladimir P. , Udut Vladimir V. 
Published: January 2020

Background:
Statins are currently used for secondary prevention of Coronary Heart
Disease (CHD), as the lipid-lowering therapy with them is proven safe and effective.

Objective:
The purpose of this research is to investigate the dose-dependent effect of statins used
for secondary prevention of coronary heart disease, as well as mechanisms of quantitative and
qualitative changes in lipoproteins, fatty acids and cholesterol in the blood and tissues of people of
both sexes.

Methods:
In a clinical trial (n=125, of which 89 patients belong to group 1 and 36 to group 2) and
an experiment on laboratory animals (n = 100), simvastatin reduced the total level of fatty acids in
blood plasma, when given in the amount that was within the therapeutic dose range.

Results:
This effect was achieved through a drug-induced improvement in the capacity of hepatic
cells to absorb Low-density (LDL) and Very-low-density (VLDL) lipoproteins.

Conclusions:
Considering the formation of saturated fatty acids, statin performed better in males.
With Omega-3 polyunsaturated fatty acids involved, changes in lipoproteins, cholesterol and fatty
acids (liver and myocardium) were similar to those caused by small doses of a statin drug. Effects
of the combination of bisoprolol and acetylsalicylic acid were completely different from those
caused by the use of statin.
Two-tier Grading System for NPDR Severities of Diabetic Retinopathy in Retinal Fundus Images
Authors: Bhardwaj Charu , Jain Shruti , Sood Meenakshi 
Published: January 2020

Background:
Diabetic Retinopathy is the leading cause of vision impairment and its early stage
diagnosis relies on regular monitoring and timely treatment for anomalies exhibiting subtle distinction
among different severity grades. The existing Diabetic Retinopathy (DR) detection approaches are subjective,
laborious and time consuming which can only be carried out by skilled professionals. All the patents
related to DR detection and diagnoses applicable for our research problem were revised by the authors. The
major limitation in classification of severities lies in poor discrimination between actual lesions, background
noise and other anatomical structures.

Methods:
A robust and computationally efficient Two-Tier DR (2TDR) grading system is proposed in this
paper to categorize various DR severities (mild, moderate and severe) present in retinal fundus images. In the
proposed 2TDR grading system, input fundus image is subjected to background segmentation and the foreground
fundus image is used for anomaly identification followed by GLCM feature extraction forming an
image feature set. The novelty of our model lies in the exhaustive statistical analysis of extracted feature set
to obtain optimal reduced image feature set employed further for classification.

Results:
Classification outcomes are obtained for both extracted as well as reduced feature set to validate the
significance of statistical analysis in severity classification and grading. For single tier classification stage,
the proposed system achieves an overall accuracy of 100% by k- Nearest Neighbour (kNN) and Artificial
Neural Network (ANN) classifier. In second tier classification stage, an overall accuracy of 95.3% with kNN
and 98.0% with ANN is achieved for all stages utilizing optimal reduced feature set.

Conclusion::
2TDR system demonstrates overall improvement in classification performance by 2% and 6%
for kNN and ANN respectively after feature set reduction, and also outperforms the accuracy obtained by
other state of the art methods when applied to the MESSIDOR dataset. This application oriented work aids in
accurate DR classification for effective diagnosis and timely treatment of severe retinal ailment.
Renal Replacement Therapy Tactics in Russian Regions with an Average Population Density
Authors: Perlin D. V. 
Published: January 2020

The lecture details the current understanding of renal replacement therapy and current advances in this field. The current diagnostic and treatment algorithms have been clarified, allowing timely assistance to the population with chronic kidney disease. I tried to identify the main milestones on the way to increasing the availability of renal replacement therapy in our country, where many regions have a very large area and low population density. Obviously, much effort remains to be done to achieve a good level of security and accessibility of renal replacement therapy for our population. I hope that this manuscript will serve to some extent the aims that have been set.The study did not have sponsorship. The author has declared no conflicts of interest
Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)
Authors: Carayol Jerome , Hosking Joanne , Pinkney Jonathan , Marquis Julien , Charpagne Aline , Metairon Sylviane , Jeffery Alison , Hager Jörg , Martin Francois-Pierre 
Published: January 2020

OBJECTIVE
Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort.

RESEARCH DESIGN AND METHODS
EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs.

RESULTS
Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity.

CONCLUSIONS
The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children.
Democracy and Growth Nexus in Indonesia
Authors: Iskandar Azwar , Subekan Achmat 
Published: January 2020

The objective of this study is to analyze the causality between democracy and economic growth in Indonesia for the period of 1995 to 2017. More specifically, this paper also attends to investigate the existence of a long-run relationship between them. This study perform a multivariate cointegration test with political stability as a control variable and cross-check this long-run relationship with an autoregressive distributed lag (ARDL) model approach to cointegration. This study also use the Granger causality test within a vector error correction model (VECM) framework and estimate three different models using a non-linear specification: Ordinary Least Squares (OLS) estimation, Fully Modified OLS (FM-OLS) and Dynamic Ordinary Least Squares (DOLS). The results show cointegration among the variables specified in the model when political stability is taken into account. Indeed, for economic growth and democracy to move together in the long run, they need to be associated with political stability. The tests for Granger causality conducted show a long-run causality running from GDP and political stability to democracy. In other word, the economic growth and political stability Granger cause democracy. It is the economic performance that influences democracy and not the reverse. In short-run, there is neutrality causation between democracy and growth, democracy and political stability, growth and political stability. These results suggest that economic growth through strong institutions is a precondition for democratization.
Comparison of Concentration Difference between ST2 and NT-Pro BNP Before and After Ace-Inhibitors in NYHA III-IV Hearts Failure Patients
Authors: Maskito Veronika Juanita , Anniwati Leonita , Aminuddin Aminuddin 
Published: January 2020

Background: The American Heart Association (2016) stated that at the age of forty the risk of developing heart failure is one in five. Medication is based on clinical signs and symptoms that are often late. Early cardiac markers are required to guide therapy. This study compared the difference between ST2 and NT-ProBNP concentrations before and after ACE inhibitors (ACE-I) in NYHA III-IV heart failure patients.Method: This was a randomized prospective observational study without controls. The respondents were males or females, 21-75 y.o in NYHA III-IV heart failure patients. Twenty-five respondents were appropriate to inclusion criteria. The ST2 was measured by Quantikine®ST2/IL-33R quantitative sandwich ELISA immunoassay while NT-proBNP was measured by Immulite Turbo® 1000.Result: Majority of respondents were males (60%) and had comorbidities(60,7%), consisting of NYHA Class III(36%) and IV(64%). Coronary artery disease and valvular heart disease (40%,36% respectively). Length of stay was 6.4±3.4days. The concentration difference of ST2 and NT-proBNP before and after ACE-I were both significant, however, NT-proBNP was more significant (p=0,001 vs p=0,023). NYHA at admission influenced ST2 difference but not NT-proBNP. NT-proBNP concentration correlated to length of stay while ST2 was not. ST2 had negative correlation with age, no correlation to GFR and weight. NT-proBNP was correlated to weight, negatively correlated to GFR, not correlated to age. ACE-I subtypes difference did not affect the study result.Conclusion: NT-proBNP was a better heart failure cardiac marker than ST2 due to its ability in diagnosis, prognosis and showing more significant difference after ACE-I administration.
CD4-T Lymphocyte in Cervical Cancer Patients on Pre-and Post-Chemotherapy
Authors: Indriastuti Endah , Retnowati Endang , Saraswati Wita 
Published: January 2020

Introduction : Cervical cancer is a gynecology cancer with the highest incidence in the Dr.Soetomo Hospital, Surabaya. Neoadjuvant chemotherapy with cisplatin has been used to increase radiosensitivy of cancer cells before radiotherapy done in advanced stage cervical cancer patients. This research aimed to know the differences of CD4-T lymphocyte profile in stage IIIB patient before and after chemotheraphy administration.Methods : This research was done in February-September 2018. Seventeen patients out of 31 stage IIIB cervical cancer patients planned to receive neoadjuvan chemotherapy with cisplatin every 3 weeks for 3 series were checked for the CD4+ T lymphocyte count and percentage. The examinations were done before the first and after the third chemotherapy administration.Results : Mean±SD of the CD4-T lymphocyte count before chemotherapy was 817±314 cells/Î¼L and mean±SD of the CD4-T lymphocyte percentage was 38.96±8.47%. While mean±SD of the CD4-T lymphocyte count after chemotherapy was 881±335 cells/Î¼L and mean±SD of the CD4-T lymphocyte percentage was 39.01±8.50%. There was no significant difference of CD4-T lymphocyte count between before and after chemotherapy (p=0.471). There was also no significant difference of CD4-T lymphocyte percentage between before and after chemotherapy (p=0.866). Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.Conclusion : The CD4-T lymphocyte count and percentage were not significantly different between before and after chemotherapy administration in stage IIIB cervical cancer patients. Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.
Non-Genetic Risk Factors for The Formation of Factor VIII Inhibitors in Hemophilia A Patients in RSUD Dr. Soetomo
Authors: Fauzi Intani Dewi Syahti , Larasati Maria C Shanty , Ugrasena I Dewa Gede 
Published: January 2020

Background: Neutralizing alloantibodies (inhibitors) is one of the complications that affect the morbidity and quality of life of hemophilia patient and can be caused by multifactorials. Genetic and inhibitors examination are not routine and expensive. Therefore, identification of non-genetic factors is important to predict the formation of inhibitors. Objective: To analyze non-genetic risk factors for the formation of factor VIII inhibitors in children with Hemophilia A. Methods: A cross-sectional study of hemophilia children aged 1-18 years at the pediatric hematology oncology outpatient clinic of Dr. Soetomo hospital in March-April 2018. Factors analyzed included the severity of hemophilia, early age of diagnosis, initial age of therapy, type of replacement therapy, frequency of factor VIII administration, and severity of bleeding by bleeding score. Statistical analysis using Chi square, Fisher, ANOVA and logistic regression analysis. Results: A total of 29 children were evaluated, 7/29 mild, 15/29 moderate, and 7/29 severe hemophilia. Inhibitors were found in 11/29 subjects, 7/11 low (1-5 BU) and 4/11 high titer (> 5 BU). The initial age of diagnosis â‰¤ 1 year is associated with the formation of factor VIII inhibitors (OR 8.75; 95% CI = 1.5-50.2; p = 0.015). Severity of hemophilia, early age of therapy, type of replacement therapy, frequency of therapy, and bleeding score was not significantly associated with the formation of factor VIII inhibitors. Conclusion: The initial age of diagnosis less than 1 year is a significant risk factor for the formation of factor VIII inhibitors.
Analysisi Platelet Indices in Patient Type 2 Diabetes Mellitus with Vascular Complication
Authors: Taggara Nelly Tolla , Aprianti Suci , ER Darmawaty 
Published: January 2020

ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION Nelly1, Suci Aprianti2 ,Darmawaty ER31Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo hospital, Makassar2Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University3Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University /Dr. Wahidin Sudirohusodo Hospital, Makassar ABSTRACT Introduction :Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition due to a decrease increase in insulin secretion and insulin resistance or both. Indonesia is the 7th country with the highest incidence of diabetes mellitus in the world. Progression of the disease is slow and cause vascular endothelial damage. The increase of platelet indices is suspected to be an indications of vascular complicationsObjective :To evaluate the platelet indices in diabetics patients with complication and correlate these indices with GDP and HbA1c. Materials and methods :We analyzed platelet indices and biochemical data of patients seen in outpatients by clinicans of wahidin soedirohusodo hospitals. 120 patients with type 2 diabetes mellitus were included with 64 patients vascular complication and 56 patients without complication.Result :We observed an increase in mean platelet volume (MPV): 9,96 + 1.99vs 8.87 + 1.35(p-value: 0,001) ;in platelet distribution width (PDW): 15.29 + 3.45 vs 12.36 + 2.819(p-value: 0,000; without increase plateletcrit (PCT); 0.28 + 0.14 vs 0.25 + 0.12 (p-value: 0.168). we observed a correlation between FBG with PDW (P=0.044).Conclusion :The study findings point to the significant differences in platelet indices (MPV and PDW) in patients with T2DM with complication and without complication, suggesting the presence of platelet in diabetics type 2 patients more reactive and aggregatable in this group of individuals. These suggest that platelet evaluation may be useful in the early detection of long term complication in diabetics patients.Keyword :T2DM, platelet indices, complication vascular
SOSIALISASI DAN PELATIHAN PEMBUATAN PUPUK ORGANIK CAIR DARI LIMBAH RUMAH TANGGA UNTUK PKK KAMPUNG AIMO
Authors: Safitri Wiji 
Published: January 2020

PKK Kampung AIMO menghadapi permasalahan yaitu terbatasnya pengetahuan dan teknologi budidaya pertanian. Hal ini yang menjadi penyebab mengapa sampai sekarang PKK Kampung AIMO tidak berjalan dengan baik. Masalah tersebut dipecahkan dengan dilakukan sosialisasi teknologi budidaya tanaman. Kegiatan sosialisasi terlebih dulu dilakukan oleh Adlian, S.P., M.Sc. “Pelatihan Penanaman Sayuran Organik di Pekarangan Rumah” sehingga menjadi cikal bakal program PKK Kampung AIMO yaitu “Pemanfaaatan Lahan Pekarangan Rumah dengan Sayuran untuk Pemenuhan Gizi Keluarga”. Kegiatan pengabdian masyarakat dengan tema “Sosialisasi dan Pelatihan Pembuatan Pupuk Organik Cair dari Limbah Rumah Tangga untuk PKK Kampung Aimo, Kab. Sorong” merupakan kegiatan lanjutan yang dilakukan untuk mendukung program kerja PKK Kampung Aimo. Kegiatan Sosialisasi dan Pelatihan Pembuatan Pupuk Organik Cair dari Limbah Rumah Tangga memberikan hasil : 1). Anggota PKK Kampung AIMO mengetahui pembuatan pupuk organik cair dari limbah rumah tangga., 2). Kampung AIMO menjadi Kampung Binaan Fakultas Teknik & Pertanian dan menjadi wadah pertukaran ilmu dan teknologi antara masyarakat dan Perguruan Tinggi., 3). Anggota PKK Kampung AIMO sudah mengetahui cara membuat Pupuk Organik Cair dari Limbah Rumah Tangga dan mampu sharing terhadap sesama anggotanya., 4). Penanaman sayur organik di pekarangan rumah dengan teknologi pemupukan organik dari limbah rumah tangga menjadi program kerja PKK Kampung AIMO.
Kata Kunci: Pupuk organik cair, Limbah rumah tangga, Lahan pekarangan rumah, Sayur organik, Kampung AIMO
ABSTRACT
PKK Kampung AIMO has the main current problem are knowledge and technology of agricultural cultivation limited. This situation causes the program PKK Kampung AIMO doesn’t work as usual. The problem solving for thus is the socialization of agricultural cultivation technology which has been done by Adlian S.P., M.Sc “Organic Vegetable Planting Training in Home Yard”and the pioneer of PKK Kampung AIMO Program is “Utilization of Home Yard Land with Vegetables for Family Nutrition Fulfillmen”. The result of training and socialization about “Making Liquid Organic Fertilizer from Household Waste” consist of 1). The member of PKK Kampung AIMO knowing to make liquid fertilizer organic from household waste, 2). Kampung Aimo and Faculty of Enggineering and Agriculture UNBN building cooperation to sharing knowledge and technology, 3). The member of PKK Kampung AIMO knowing to sharing knowledge with others, 4). Organic vegetables planting in home yard with liquid organic fertilization from household waste become a program in PKK Kampung AIMO.
Keywords: Liquid organic fertilizer, Household waste, Homeyard land, Organic vegetable, AIMO village
Nowe miasto Boże w ujęciu Ezechiela (Ez 48,30-35)
Authors: Jasiński Andrzej Sebastian 
Published: January 2020

W duchu dialogu judaistyczno-chrześcijańskiego, w artykule zajmuję się tekstem Ez 48,30-35, który jest bardzo ważny dla obu wspólnot wierzących.
Ostatnia wizja Ezechiela (Ez 40–48) stała się źródłem inspiracji dla judaizmu i chrześcijaństwa. Nie ma jednak zgodności w interpretacji tej prorockiej zapowiedzi: nastania nowej świątyni i nowego miasta. Świątynia (+ miasto) została przedstawiona w świetle judaizmu rabinackiego, pism qumrańskich oraz samego Ezechiela.
W części egzegetycznej przebadano dokładnie tekst Ez 48,30-35. Na zakończenie zostały przedstawione wnioski teologiczne w sześciu punktach: Chwała Jahwe; Dziedzictwo patriarchów; Potęga Jahwe; Obecność Jahwe; Nadzieja Izraela; Recepcja chrześcijańska.
Księga Ezechiela pozostaje jednym z najbardziej tajemniczych pism biblijnych. Jej potencjał teologiczny nie zawsze jest doceniany. Odnosi się to również do kwestii dialogu międzyreligijnego. Ezechiel był heroldem świętości imienia Jahwe oraz poznania Boga: Pana całego stworzenia, obecnego pośrodku swego ludu. Prawdy te stanowią trzon credo zarówno Żydów jak i chrześcijan. Wspólna ich kontemplacja pozwala na wzajemne zbliżenie, które w końcu wszystkich pragnących doprowadzi do miasta nazwanego Jahwe (jest) tam (Ez 45,35).
Wybrane teologiczne wątki dokumentu dialogu katolicko-anglikańskiego pt. "Walking Together on the Way" w kontekście aktualnych wyzwań posoborowego ekumenizmu
Authors: Beyga Paweł 
Published: January 2020

Ekumenizm stanowi niezwykle ważną działalność Kościoła katolickiego. Główną realizacją tej aktywności są prace specjalnych grup i komisji pomiędzy Kościołem katolickim a innymi chrześcijańskimi wspólnotami i kościołami. Międzynarodowa Anglikańko-Rzymskokatolicka Komisja (ARCIC) jest grupą utworzoną w 1969 roku, kóra dąży do ekumenicznego postępu pomiedzy Kosciołem katolickim a Kościołem katolickim. Trzecia faza prac Międzynarodowej Anglikańko-Rzymskokatolickiej Komisji zaowocowała wspólnym dokumentem zatytułowanym Walking together on the Way: Learning to be a Church - Local, Regional, Universal. Ten eklezjologiczny dokument ukazał relacje pomiędzy Kościołami lokalnymi i powszechnym, rolę arcybiskupa Canterbury oraz biskupa Rzymu, a także kondycję wspólnoty anglikańskiej w całym świecie. Autor artykułu spojrzał na ten nowy dokument ekumeniczny z perspektywy sytuacji dialogu ekumenicznego i nauczania II Soboru Watykańskiego oraz papieża emeryta Benedykta XVI.