bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA‐mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high‐throughput sequencing
Authors: Zhou Hailun , Chen Donghui , Xie Guifang , Li Jiaojie , Tang Jianjia , Tang Li 
Published: April 2020

AbstractBackground and ObjectiveAlthough periimplantitis and periodontitis share similar features, particularly clinical features, they are two different diseases and should be analyzed separately. Thus far, few omics‐level differences in periimplantitis and periodontitis have been reported. This study was aimed at exploring the differential effects of expression mRNAs, lncRNAs, and miRNAs in periodontitis and periimplantitis by high‐throughput sequencing and competitive endogenous RNA (ceRNA) analysis.MethodsGingival tissues of healthy individuals (HI) and periimplantitis (PI) and periodontitis (P) patients were collected and used for genome‐wide sequencing. The differentially expressed genes (DEGs) were screened and visualized by R software. The functions and pathways of DEGs were analyzed using Metascape, and the ceRNA network was constructed using the Cytoscape software. Finally, gene set enrichment analysis (GSEA) was used to predict the function of key nodes in ceRNA.Results and ConclusionBy constructing the regulated ceRNA network, six genes (FAM126B, SORL1, PRLR, CPEB2, RAP2C, and YOD1) and 16 miRNAs (hsa‐miR‐338‐5p, hsa‐miR‐650, hsa‐miR‐9‐5p, hsa‐miR‐1290, hsa‐miR‐544a, hsa‐miR‐3179, hsa‐miR‐1269a, hsa‐miR‐3679‐5p, hsa‐miR‐149‐5p, hsa‐miR‐615‐3p, hsa‐miR‐33b‐5p, hsa‐miR‐31‐5p, hsa‐miR‐4639‐5p, hsa‐miR‐204‐5p, hsa‐miR‐5588‐5p, and hsa‐mir‐196a‐5p) were detected. Five long non‐coding RNAs (lnc‐CORO2B‐1, lnc‐MBL2‐7, lnc‐TRIM45‐1, lnc‐CHST10‐2, and lnc‐TNP1‐6) were found to target these miRNAs in this ceRNA network. The ceRNA network based on transcriptome data revealed that FAM126B, SORL1, PRLR, CPEB2, RAP2C, and YOD1 were crucial proteins of differential effects in periodontitis and periimplantitis. The lncRNA‐miRNA‐mRNA interaction involved the regulation of the Hippo signaling pathway, Wnt signaling pathway, Toll‐like receptor signaling pathway, NOD signaling pathway, oxidative stress, and innate immune process. These regulated pathways and biological processes may be factors contributing to the pathogenesis of periimplantitis being distinct from that of periodontitis.
The COVID‐19 pandemic: Anticipating its effects on Canada's agricultural trade
Authors: Barichello Richard 
Published: April 2020

AbstractWith the deep recession now forecast for the world economy, trade can be expected to fall even more steeply. Agricultural trade will be less significantly affected, being insulated by its relatively low income elasticities of demand. However, a drop in the range of 12%–20% in real trade value should be expected. Canada can be expected to share in this, but, within agricultural exports, cereals will be least affected. This minimal expected impact to cereals stems partly from the risk of wheat export bans by Russia and Kazakhstan, due to increases in wheat prices. Livestock, pulses, and horticulture exporters can be expected to face a larger decline in trade prospects and revenues. An equally large threat, along with falling incomes in our trade partners, is their policy responses, particularly the potential increase in import restrictions. These may take the form of more costly inspections, tightened SPS and food safety regulations, and protectionist measures from competing domestic producers.
Weight bias internalization and its association with health behaviour adherence after bariatric surgery
Authors: Feig Emily H. , Amonoo Hermioni L. , Onyeaka Henry K. , Romero Perla M. , Kim Sonia , Huffman Jeff C. 
Published: April 2020

SummaryThis study tested the hypothesis that internalized weight bias (WBI) is negatively associated with health‐related quality of life, weight loss and health behaviour adherence (eg, physical activity, diet, vitamin adherence) in patients who had weight loss surgery (WLS). It also tested whether self‐efficacy for exercise, barriers to being active and depression were mediators between WBI and moderate‐to‐vigorous physical activity (MVPA). Participants were recruited from online support forums. They completed an anonymous online survey assessing WBI, physical activity, health behaviour adherence, depression, health‐related quality of life, self‐efficacy for exercise and barriers to being physically active. Multiple regression analyses and a bootstrapping approach for mediation were used. The sample included 112 primarily white and female adults, who had surgery 1 month to 24 years prior. WBI was negatively associated with weight loss since surgery, MVPA, dietary adherence, vitamin adherence and mental health‐related quality of life, and was not associated with walking, physical health‐related quality of life or fluid intake adherence. Self‐efficacy for exercise, barriers to being active and depression were partial mediators between WBI and physical activity. After WLS, WBI may signal poorer adherence to critical health behaviours. It also is associated with less weight loss. WBI should be assessed and treated by WLS providers.
Bycatch in local fishery disrupts natural reestablishment of Eurasian otter in western Norway
Authors: Landa Arild , Guidos Steven 
Published: April 2020

AbstractLack of proper estimates of nonreported bycatch has made it difficult to evaluate the actual impact of bycatch in many local fisheries. For the Eurasian otter (Lutra lutra), there are no published estimates on the extent to which bycatch is unreported, despite nonreporting being a well‐known issue. Through public outreach efforts in local news and media we collected information from citizen scientists on nonreported otter mortalities of a small‐scale fishery in western Norway along the recent natural expansion front of otters. We compared this to deaths that were properly registered by local authorities. In total, cause of mortality was determined from 218 otters between 2003 and 2018. We found that the chances of a mortality being properly reported varied between type of death. Drowning in fyke and gillnets were the most common cause of mortality, and at least 61 and 69% of these deaths were never reported, respectively. The high level of bycatch occurring in the otters' current region of expansion is likely to have demographic impacts and hinder otter reestablishment in the area. Banning the use of fyke nets and setting a minimum fishing depth for gillnets would enhance otter recovery and simultaneously alleviate bycatch of other nontarget species in the region, while having little economic impact on a fishery which is mostly noncommercial. The case of the otter is a classic example of lack of communication between government agencies which have so far failed to establish platforms where issues like this can be discussed and solved by adequate law implementation.
Density dependence mediates the ecological impact of an invasive fish
Authors: DeRoy Emma M. , Scott Ryan , Hussey Nigel E. , MacIsaac Hugh J. 
Published: April 2020

AbstractAimThe way in which habitat heterogeneity and predator density affect predator–prey dynamics, space use and prey risk are understudied aspects of foraging ecology, particularly for invasive species. Likewise, how an invasive species’ impact scales with its abundance is poorly understood. We used a model invasive species—lionfish (Pterois volitans)—to understand emergent multiple predator effects and influences of habitat heterogeneity on consumption rate and prey mortality risk.LocationFlorida, USA.MethodsWe considered effects of both predator and prey abundance on density‐dependent impact. We used functional response methodology to quantify the per‐capita effect ofP. volitans, assessing concomitant influences of prey refuge (3 levels) and predator density (3 levels) on predator–prey space use and predation efficiency across increasing prey densities (7 levels). We then assessed intraspecific interaction outcomes by comparing observed per‐capita effects with predicted estimates based on consumption rates of individual predators. This allowed us to detect the presence of emergent multiple predator effects (MPEs) and tease apart density‐dependent impacts.ResultsLionfish predatory impact was mediated by predator and prey density but unaffected by refugia. Despite incongruent patch preferences between predators and their prey, predator impacts were context‐independent. We also detected nonlinear scaling of impact with increasing predator abundance. Pairs of lionfish had the greatest per‐capita effect, whose cumulative impact on prey matched that expected of independently foraging predators. At the highest predator density (four fish), antagonistic multiple predator effects precipitated prey risk reduction, in which we observed the lowest per‐capita effect. Across predator abundances, prey mortality rates were inversely density‐dependent.Main conclusionsQuantifying non‐independent consumptive effects of multiple conspecific predators across levels of prey abundance can inform better prediction and understanding of invasive species' density‐dependent effects. Additionally, consideration of heterogeneity‐mediated FRs and predator–prey spatial distributions may facilitate more precise and realistic predictions of invader impact across their invaded range.
Off to a good start: Early Spanish‐language processing efficiency supports Spanish‐ and English‐language outcomes at 4½ years in sequential bilinguals
Authors: Marchman Virginia A. , Bermúdez Vanessa N. , Bang Janet Y. , Fernald Anne 
Published: April 2020

AbstractMany Latino children in the U.S. speak primarily Spanish at home with few opportunities for exposure to English before entering school. For monolingual children, the strongest early predictor of later school success is oral language skill developed before kindergarten. Less is known about how early oral language skills support later learning in sequential bilingual children. A question with wide‐reaching significance is whether skill in a child's first language (L1) supports later learning in a second language (L2). In this longitudinal study of sequential Spanish‐English bilinguals, we assessed oral language skills in Spanish at 2 years through parent reports of vocabulary size and children's real‐time language processing efficiency (Accuracy, RT) in the ‘looking‐while‐listening’ (LWL) task. At 4½ years, we assessed language outcomes in both Spanish and English using standardized tests. Reported relative exposure to each language was significantly correlated with language outcomes in Spanish and English. Within‐language relations were observed between Spanish vocabulary size and processing efficiency at 2 years and later Spanish‐language outcomes. Critically, across‐language relations were also observed: Children with stronger Spanish‐language processing efficiency at 2 years had stronger English‐language skills at 4½ years, controlling for socioeconomic status and exposure to English. Children's early language processing efficiency in Spanish is associated with stronger real‐time information processing skills that support maintenance of Spanish and learning in English when these children enter school. These results support the recommendation that primarily Spanish‐speaking families should engage in activities that promote children's Spanish‐language skills while also seeking opportunities for children to be exposed to English.
Therapeutic uncertainties in people with cardiometabolic diseases and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19)
Authors: Khunti Sachin , Khunti Nitisha , Seidu Samuel , Khunti Kamlesh 
Published: April 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19) has been declared a pandemic by the World Health Organization and sent all countries scrambling to review emergency healthcare provisions. There is global evidence of each nation struggling to effectively manage the number of people being diagnosed with the virus. These are testing times which have not been experienced in recent generations and there are a number of insecurities regarding the management of people with COVID‐19 and cardiometabolic diseases. This review highlights the current concerns related to COVID‐19 and provides advice in terms of the therapeutic uncertainty and potential adverse harms associated with therapy when managing people, particularly those with cardiometabolic diseases, who have contracted or are at increased risk of contracting COVID‐19.
Erdoğan’s pragmatism and the ascension of AKP in Turkey: Islam and neo‐Ottomanism
Authors: Gontijo Lorenzo C. B. , Barbosa Roberson S. 
Published: April 2020

AbstractThis article aimed to analyze the ascension of Justice and Development Party—Adalet ve Kalkınma Partisi(AKP)—in Turkey and its political measures regarding both Islam and the country's Ottoman past, in order to comprehend the party's role in a potential shift of Turkish national identity and in Turkey's relationship with the Middle East. The article does this through a content analysis of decrees, laws, and other measures taken by the AKP that emphasizes its cultural and religious policies, as well as revisiting literature produced about the subject. Analyzing Recep Tayyip Erdoğan's government during his time as Prime Minister (2003–2014), two noteworthy features come to light: its Islamic influence and its so‐called neo‐Ottomanist outlook. However, this article argues that besides an identity‐ and ideology‐based motivation, the AKP had pragmatic intentions in adopting such approaches, aiming to gather support both domestically and regionally.
Contemporary conflicts, cross‐border military operations, and the declining role of the UN: The case of Turkey and Saudi Arabia
Authors: Nyadera Israel Nyaburi , Kisaka Michael Otieno 
Published: April 2020

AbstractThis article examines an emerging trend of cross‐border conflicts between states and non‐state actors. It looks at the narratives fronted by Turkey and Saudi Arabia to justify their operations in northern Syria and Yemen, respectively. The authors argue that the increased inaction and lack of influence by the UN in response to such operations reaffirm states as the core actors in international politics and that national security and interests continue to shape the behavior of actors at the international level. The article concludes that the UN needs to adjust to the new forms of conflicts, actors, and behavior being experienced at the international level if it is to retain its relevance as an anchor of peace and international security.
Right aortic arch, bilateral ductus arteriosus, and anomalous origin of left pulmonary artery from innominate artery in a fetus with normal intracardiac anatomy
Authors: Karmegaraj Balaganesh , Vaidyanathan Balu 
Published: April 2020

AbstractRight aortic arch (RAA) with right ductus arteriosus (RDA) is one of the least frequently diagnosed cardiac abnormalities prenatally. We describe here a case of RAA, bilateral ductus arteriosus (BDA), and anomalous origin of left pulmonary artery from innominate artery in a fetus with normal intracardiac anatomy.
State versus private provision: How does China’s market‐oriented reform affect healthcare delivery?
Authors: Fang Guanfu , Cao Hui 
Published: April 2020

AbstractThe role of the government in health care provision remains a contested issue worldwide. Public hospitals dominate China’s health care industry. However, in the early 2000s, the eastern China city of Suqian privatized all its hospitals and relaxed entry barriers for private hospitals. We assess the impact of the pro‐market reform on hospital performance using a differences‐in‐differences approach. We find that the pro‐market reform decreased medical price and expenditure, improved self‐reported health outcomes, and reduced search time and cost for patients. We show that after the reform, Suqian residents had greater trust in doctors than did residents from other cities.
Pre‐pubertal, low‐intensity exercise does not require concomitant venlafaxine to induce robust, late‐life antidepressant effects in Flinders sensitive line rats
Authors: Steyn Stephan F. , Harvey Brian H. , Brink Christiaan B. 
Published: April 2020

AbstractA significant number of adolescents are considered insufficiently active. This is of concern considering the negative association between physical activity and major depressive disorder (MDD). There is a lack of approved pharmacological treatment options in this population partly due to limited information on the risks associated with lasting effects during early life. Therefore, interest in non‐pharmacological strategies is gaining popularity with low‐ to moderate‐intensity exercise being especially attractive for its antidepressant‐like effects and augmentation properties in combination with antidepressants. Early‐life development might present a unique “window of opportunity” to induce long‐term beneficial effects in individuals treated with central acting drugs, such as antidepressants. Therefore, we investigated the bio‐behavioural effects of pre‐pubertal, low‐intensity exercise (EXE) and/or venlafaxine (VEN) on depressive‐like behaviour in juvenile (postnatal day 35 (PND35)) and young adult (PND60) stress‐sensitive Flinders sensitive line (FSL) rats. Interventions were introduced during pre‐pubertal development, that is PND21‐34, followed by a 26‐day washout/sedentary period, when bio‐behavioural analyses were performed in the early adulthood group. VEN, alone or in combination with EXE, proved ineffective in inducing any bio‐behavioural changes in either age group. EXE did not induce early‐life antidepressant‐like effects, despite increasing frontal serotonin (5‐HT) and noradrenaline (NA) levels. Later in life (PND60), pre‐pubertal exercise reduced immobility and increased coping behaviours, together with increased cortical 5‐HT levels, despite a significant reduction in locomotor activity. These findings emphasize a strong serotonergic basis to the observed delayed antidepressant effects of EXE later in life.
Co‐Parenting Programs: A Systematic Review and Meta‐Analysis
Authors: Eira Nunes Cindy , de Roten Yves , El Ghaziri Nahema , Favez Nicolas , Darwiche Joëlle 
Published: April 2020

ObjectiveThis article aims to provide an overview of the efficacy of co‐parenting programs on outcomes related to child's adjustment, parents' well‐being, and quality of the co‐parenting, romantic, and parent–child relationships.BackgroundNumerous co‐parenting programs have been developed, supported by empirical findings associating quality of co‐parenting to the overall family well‐being. However, to our knowledge, the efficacy of those programs has not yet been assessed.MethodThis article included 38 articles corresponding to 27 randomized controlled trials (RCTs) presenting 23 programs. We conducted a meta‐analysis to estimate the efficacy of co‐parenting programs and a review of programs to identify the ingredients of co‐parenting programs that may contribute to this efficacy.ResultsResults support a small but significant effect of co‐parenting programs on outcomes related to parents' well‐being and the quality of co‐parenting and romantic relationships.ConclusionFinally, despite the heterogeneity of the programs, some commonalities are identified, such as the use of psychoeducation and skills training.ImplicationsOur work supports the added value of co‐parenting programs for both vulnerable families and families with no apparent major difficulties. Future directions in terms of study and program designs are proposed to promote high‐quality research in this field.
Fatigue response up to 109 cycles of a structural epoxy adhesive
Authors: Tridello Andrea , Ciardiello Raffaele , Paolino Davide Salvatore , Goglio Luca 
Published: April 2020

AbstractIn the present paper, the very‐high‐cycle fatigue (VHCF) response of a structural adhesive used for automotive applications, Betaforce 4600G modified with microspheres, has been experimentally assessed. Ultrasonic fully reversed tension–compression tests up to 109 cycles have been carried out with the testing machine developed by the authors on adhesives without macroscopic defects and on adhesives with artificial defects, inserted during the butt‐joint preparation. Fracture surfaces have been observed with the optical microscope and the P‐S‐N curves estimated. Experimental results have shown that defect location significantly affects the VHCF strength and fracture surfaces exhibit a peculiar morphology with three distinct characteristic regions.
Plant's‐eye view of temperature governs elevational distributions
Authors: Liancourt Pierre , Song Xin , Macek Martin , Santrucek Jiri , Dolezal Jiri 
Published: April 2020

AbstractExplaining species geographic distributions by macroclimate variables is the most common approach for getting mechanistic insights into large‐scale diversity patterns and range shifts. However, species' traits influencing biophysical processes can produce a large decoupling from ambient air temperature, which can seriously undermine biogeographical inference. We combined stable oxygen isotope theory with a trait‐based approach to assess leaf temperature during carbon assimilation (TL) and its departure (ΔT) from daytime free air temperature during the growing season (Tgs) for 158 plant species occurring from 3,400 to 6,150 m a.s.l. in Western Himalayas. We uncovered a general extent of temperature decoupling in the region. The interspecific variation in ΔT was best explained by the combination of plant height and δ13 C, and leaf dry matter content partly captured the variation in TL. The combination of TL and ΔT, with ΔT contributing most, explained the interspecific difference in elevational distributions. Stable oxygen isotope theory appears promising for investigating how plants perceive temperatures, a pivotal information to species biogeographic distributions.