bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug‐Disease Interaction and Time‐Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients
Authors: Fau Jean‐Baptiste , El‐Cheikh Raouf , Brillac Claire , Koiwai Kimiko , Mace Nathalie , Campana Frank , Semiond Dorothee , Nguyen Laurent 
Published: October 2020

Isatuximab, a monoclonal antibody (mAb) of immunoglobulin G (IgG) isotype, specifically targets the cluster of differentiation 38 antigen overexpressed in malignant plasma cells. Isatuximab is used to treat multiple myeloma (MM), characterized by the excessive production of abnormal “myeloma proteins” (M‐proteins) that may interact with therapeutic IgG mAb on the neonatal Fc receptor (FcRn)‐mediated recycling pathway. The clinical pharmacology profile of isatuximab was investigated by population pharmacokinetics (PKs) modeling in 476 patients with MM who received 1–20 mg/kg isatuximab either as single agent or in combination with pomalidomide‐dexamethasone in 4 clinical trials. Isatuximab PKs were characterized by a two‐compartment model with parallel time‐varying linear clearance (CL) and nonlinear elimination. Due to a mechanism‐based drug‐disease interaction, patients secreting IgG M‐protein exhibited a twofold lower drug exposure compared with patients with non‐IgG MM. No dose adjustment was required based on MM immunoglobulin type because efficacy and safety profiles were comparable between IgG and non‐IgG MM subpopulations. β2‐microglobulin, body weight, sex, drug material, and race have a limited effect on drug exposure and do not require any dose adjustment. A typical 50% decrease in linear CL from initial treatment to steady‐state was predicted, and this decrease correlated with the best overall response rate and was slower for patients with IgG MM. These findings suggest that the time‐dependent effect of isatuximab is likely mediated by a combined factor of both disease state evolution and the perturbation of the FcRn‐mediated recycling pathway.
Bank erosion in a macrotidal tropical river: Exploring the relative impact of boat wash on riverbank erosion
Authors: Novak Peter A. , Fairfield Charlie A. , Miloshis Mike , Knight Zoe C. , Lindsay Robert , King Alison J. 
Published: October 2020

AbstractMacrotidal tropical rivers are dynamic systems where wet‐season floods and tidal flows cause significant riverbank erosion and sediment transport. This study aimed to explore patterns of riverbank erosion and deposition in a large, tropical, macrotidal river in Northern Australia; the Daly River. In particular, we aimed to determine if recreational boat use was impacting bank erosion in this dynamic river. Erosion pins were installed at multiple levels on both banks at 10 sites along a 34 km reach of the river. Measurements were made every four to six weeks during the low water dry season, and opportunistically during the wet season (flooding period) and seasonal transition periods. A bank geotechnical assessment, riverbed cross‐sections and site bathymetry were undertaken. Whilst the wet season was a period of substantial erosion (mean rate of 0.64 mm day−1), the highest mean erosion rate (3.6 mm day−1) was observed in the early dry season (April to May), a period of stabilizing water levels but greatest boat traffic. Bank erosion at this time was measured on both sides of the river and the inside of meander bends, which is atypical of normal riverine bank erosion patterns, and indicative of erosion due to boat wash. As the dry season progressed, significant spatial differences in erosion rates were evident, where erosion was observed at sites upstream of a large shallow sand bar, while sites downstream from the sand bar gained material through the deposition of tidally transported sediment. This study highlights the importance of understanding the significance and interaction of various erosive factors in tropical tidal rivers and has demonstrated that boat wash may be an important contributor to dry season bank erosion in these systems. We encourage management agencies to consider the role of boats in any future river management program in these systems.
Performance outcomes of supply chain practices for sustainable development: A meta‐analysis of moderators
Authors: Qorri Ardian , Gashi Saranda , Kraslawski Andrzej 
Published: October 2020

AbstractSustainable supply chain management (SSCM) practices have received growing attention but their consequences on firm performance yielded mixed outcomes. This study aims to synthesize quantitative research and to analyze potential moderators on the link between SSCM practices and firm performance. This study draws upon resource‐based view of the firm with the extensions of natural resource‐based view and relational view to underpin study hypotheses. The analysis is based on data collected from 145 independent samples composed of 33,886 firms. The research hypotheses are tested using meta‐analytical procedures. The results show that SSCM practices are significantly and positively correlated with firm's social, operational, economic, and environmental performance dimensions. Additional findings from moderator analysis provide nuanced views of SSCM practices‐performance link. This paper contributes to the literature by underlining the relevance of SSCM, identifying and classifying SSCM practices into a coherent framework. The research findings help policy makers, practitioners and other stakeholders to better understand benefits from the adoption of SSCM practices. Additionally, to the best of authors' knowledge, this is the first study that meta‐analytically combined existing empirical evidence of the social supply practices on various types of firm's sustainability performance.
Development of Electrocoagulation and Detection Approaches for Manipulation of Volatile Compound Profiles in Organic Medium Supported Using Two‐Phase Electrolyte System
Authors: Thaveesangsakulthai Isaya , Wacharasindhu Sumrit , Vchirawongkwin Viwat , Nhujak Thumnoon , Chailapakul Orawon , Kulsing Chadin 
Published: October 2020

AbstractElectrocoagulation (EC) approach employing two aluminium electrodes and a two phase medium of aqueous solution of NaCl and hexane (2‐phase‐EC) was developed. The approach enabled electrochemical treatment of odor active compounds in perfume extract. The samples before and after 2‐phase‐EC at cathode, anode and between the two electrodes left for equilibrium after the treatment were analyzed by using solid phase micro extraction (SPME) and gas chromatography hyphenated with mass spectrometry (GC−MS). This allowed identification of volatile compounds in each sample based on comparison with MS and retention index database. After the treatment, the perfume smells were fresher, sweeter and more floral corresponding to their different types and amounts of the odor active compounds. The major odor active products mainly obtained at the anode of the 2‐phase‐EC system were methyl benzoate, 2‐phenylethanol and benzyl acetate. The corresponding product at the cathode was phenylmethanol. Comparison of the investigated sample profiles further reveals enrichment of several compounds at each electrode without undergoing electrochemical reaction. The major reactant and product profiles were further investigated with Gas Analyzer revealing slower rate of decrease in the amounts of the characteristic m/z of the products during the 2‐phase EC. The 2‐phase‐EC and analytical approach have a potential for application in the area of electrochemical reaction in organic media in the future.
Genomics literacy matters: Supporting the development of genomics literacy through genetics education could reduce the prevalence of genetic essentialism
Authors: Donovan Brian M. , Weindling Monica , Salazar Brae , Duncan Alex , Stuhlsatz Molly , Keck Phillip 
Published: October 2020

AbstractRecently, it has been argued that improving students' genomics literacy could prevent students from developing erroneous beliefs about social identity, such as the belief that racial groups differ cognitively and behaviorally because of their genes; a belief called genetic essentialism. To date, however, little research has explored if or how a conceptual understanding of genomics protects against the development of genetic essentialism. Using a randomized control trial (RCT) (N = 721, 9th–12th graders), we explore if students with more genomics literacy are more able to conceptually change their genetic essentialist beliefs after engaging in a learning experience designed to refute essentialist thinking. The results of the RCT demonstrated that students with higher genomics literacy (relative to those with lower genomics literacy) exhibited greater reductions in the perception of racial differences and greater reductions in belief in genetic essentialism after learning how patterns of human genetic variation refute genetic essentialism. These results suggest that genetics education can protect students from developing a belief in genetic essentialism when it provides them with opportunities to learn multifactorial genetics and population thinking in conjunction with how these concepts refute essentialist thinking.
A non-linear EFT description of gg → H H at NLO interfaced to POWHEG
Authors: Heinrich Gudrun , Jones Stephen P. , Kerner Matthias , Scyboz Ludovic 
Published: October 2020

Abstract
We present the implementation of Higgs boson pair production in gluon fusion within a non-linear Effective Field Theory framework containing five anomalous couplings for this process. The code, available within the POWHEG-BOX-V2, includes full NLO QCD corrections with massive top quarks. All five couplings can be modified by the user. We show mhh distributions at seven benchmark points provided by an mhh shape analysis at NLO and showered $$ {p}_T^{hh} $$

p
T
hh

distributions resulting from an interface to PYTHIA-8 and HERWIG-7.2.
Dynamical evolution of gravitational leptogenesis
Authors: McDonald Jamie I. , Shore Graham M. 
Published: October 2020

Abstract
Radiatively-induced gravitational leptogenesis is a potential mechanism to ex- plain the observed matter-antimatter asymmetry of the universe. Gravitational tidal effects at the quantum loop level modify the dynamics of the leptons in curved spacetime and may be encoded in a low-energy effective action Seff . It has been shown in previous work how in a high-scale BSM theory the CP odd curvature-induced interactions in Seff modify the dispersion relations of leptons and antileptons differently in an expanding universe, giving rise to an effective chemical potential and a non-vanishing equilibrium lepton-antilepton asymmetry. In this paper, the CP even curvature interactions are shown to break lepton number current conservation and modify the evolution of the lepton number density as the universe expands. These effects are implemented in a generalised Boltzmann equation and used to trace the dynamical evolution of the lepton number density in different cosmological scenarios. The theory predicts a potentially significant gravitationally-induced lepton-antilepton asymmetry at very early times in the evolution of the universe.
Secularly growing loop corrections in scalar wave background
Authors: Akhmedov E. T. , Diatlyk O. 
Published: October 2020

Abstract
We consider two-dimensional Yukawa theory in the scalar wave background ϕ(t − x). If one takes as initial state in such a background the scalar vacuum corresponding to ϕ = 0, then loop corrections to a certain part of the Keldysh propagator, corresponding to the anomalous expectation value, grow with time. That is a signal to the fact that under the kick of the ϕ(t − x) wave the scalar field rolls down the effective potential from the ϕ = 0 position to the proper ground state. We show the evidence supporting these observations.
The impact of a qualified medical documentation assistant on trauma room management
Authors: Lucas Benjamin , Mathieu Sophie-Cecil , Pliske Gerald , Schirrmeister Wiebke , Kulla Martin , Walcher Felix 
Published: October 2020

Abstract
Purpose
To improve quality of trauma room management, intra- and inter-hospital benchmarking are important tools. However, primary data quality is crucial for benchmarking reliability. In this study, we analyzed the effect of a medical documentation assistant on documentation completeness in trauma room management in comparison to documentation by physicians involved in direct patient treatment.

Methods
We included all patients treated in the trauma room from 2016/01/01 to 2016/12/31 that were documented with the trauma module of the German Emergency Department Medical Record V2015.1. We divided the data into documentation by medical documentation assistant (DA, 07:00 to 17:00), physician in daytime (PD, 07:00 to 17:00), and physician at night (PN, 17:00 to 07:00). Data were analyzed for completeness (primary outcome parameter) as well as diagnostic intervals.

Results
There was a significant increase in complete recorded data for DA (74.5%; IQR 14.5%) compared to PD (26.9%; IQR 18.7%; p < 0.001) and PN (30.8%; IQR 18.9; p < 0.001). The time to whole-body computed tomography (WBCT) significantly decreased for DA (19 min; IQR 8.3) compared to PD (24 min; IQR 12.8; p = 0.007) or PN (24.5 min; IQR 10.0; p = 0.001).

Conclusion
In presence of a qualified medical documentation assistant, data completeness and time to WBCT improved significantly. Therefore, utilizing a professional DA in the trauma room appears beneficial for data quality and time management.
Patient-specific metal implants for focal chondral and osteochondral lesions in the knee; excellent clinical results at 2 years
Authors: Holz Johannes , Spalding Tim , Boutefnouchet Tarek , Emans Pieter , Eriksson Karl , Brittberg Mats , Konradsen Lars , Kösters Clemens , Verdonk Peter , Högström Magnus , Lind Martin 
Published: October 2020

Abstract
Purpose
Surgical treatment options for the management of focal chondral and osteochondral lesions in the knee include biological solutions and focal metal implants. A treatment gap exists for patients with lesions not suitable for arthroplasty or biologic repair or who have failed prior cartilage repair surgery. This study reports on the early clinical and functional outcomes in patients undergoing treatment with an individualised mini-metal implant for an isolated focal chondral defect in the knee.

Methods
Open-label, multicentre, non-randomised, non-comparative retrospective observational analysis of prospectively collected clinical data in a consecutive series of 80 patients undergoing knee reconstruction with the Episealer® implant. Knee injury and Osteoarthritis Outcome Score (KOOS) and VAS scores, were recorded preoperatively and at 3 months, 1 year, and 2 years postoperatively.

Results
Seventy-five patients were evaluated at a minimum 24 months following implantation. Two patients had undergone revision (2.5%), 1 declined participation, and 2 had not completed the full data requirements, leaving 75 of the 80 with complete data for analysis. All 5 KOOS domain mean scores were significantly improved at 1 and 2 years (p < 0.001–0.002). Mean preoperative aggregated KOOS4 of 35 (95% CI 33.5–37.5) improved to 57 (95% CI 54.5–60.2) and 59 (95% CI 55.7–61.6) at 12 and 24 months respectively (p < 0.05). Mean VAS score improved from 63 (95% CI 56.0–68.1) preoperatively to 32 (95% CI 24.4–38.3) at 24 months. The improvement exceeded the minimal clinically important difference (MCID) and this improvement was maintained over time. Location of defect and history of previous cartilage repair did not significantly affect the outcome (p > 0.05).

Conclusion
The study suggests that at 2 years, Episealer® implants are safe with a low failure rate of 2.5% and result in clinically significant improvement. Individualised mini-metal implants with appropriate accurate guides for implantation appear to have a place in the management of focal femoral chondral and osteochondral defects in the knee.

Level of evidence
IV.
Firm size populations modeled through competition-colonization dynamics
Authors: Applegate J. M. , Lampert Adam 
Published: October 2020

AbstractThe Firm Ecosystem Model is a dynamical model based on the empirical finding that firm characteristics, such as the tendency to innovate and competitive advantages, vary according to firm size. Firm dynamics leading to various population distributions are considered as a competition-colonization scenario in a spatially defined market, where firms of differing sizes are treated as separate species with different competition and colonization characteristics. Smaller firms, given adequate investment funds to innovate, are able to colonize available space more quickly than larger firms, and larger firms are assumed to have stronger competition characteristics and are able to outcompete smaller firms for occupied space. With startup and mortality parameters determined empirically, firm populations reach equilibria dependent on the values of the capital investment parameters. The model predictions provide a good qualitative fit to empirical data from the Business Dynamics Statistics database. Finally, we explore how alternative mortality or investment conditions affect the firm size distributions.
Fluctuations Around a Homogenised Semilinear Random PDE
Authors: Hairer Martin , Pardoux Étienne 
Published: October 2020

AbstractWe consider a semilinear parabolic partial differential equation in $$\mathbf{R}_+\times [0,1]^d$$

R
+

×

[
0
,
1
]

d

, where $$d=1, 2$$

d
=
1
,
2

or 3, with a highly oscillating random potential and either homogeneous Dirichlet or Neumann boundary condition. If the amplitude of the oscillations has the right size compared to its typical spatiotemporal scale, then the solution of our equation converges to the solution of a deterministic homogenised parabolic PDE, which is a form of law of large numbers. Our main interest is in the associated central limit theorem. Namely, we study the limit of a properly rescaled difference between the initial random solution and its LLN limit. In dimension $$d=1$$

d
=
1

, that rescaled difference converges as one might expect to a centred Ornstein–Uhlenbeck process. However, in dimension $$d=2$$

d
=
2

, the limit is a non-centred Gaussian process, while in dimension $$d=3$$

d
=
3

, before taking the CLT limit, we need to subtract at an intermediate scale the solution of a deterministic parabolic PDE, subject (in the case of Neumann boundary condition) to a non-homogeneous Neumann boundary condition. Our proofs make use of the theory of regularity structures, in particular of the very recently developed methodology allowing to treat parabolic PDEs with boundary conditions within that theory.
Epigenomic, genomic, and transcriptomic landscape of schwannomatosis
Authors: Mansouri Sheila , Suppiah Suganth , Mamatjan Yasin , Paganini Irene , Liu Jeffrey C. , Karimi Shirin , Patil Vikas , Nassiri Farshad , Singh Olivia , Sundaravadanam Yogi , Rath Prisni , Sestini Roberta , Gensini Francesca , Agnihotri Sameer , Blakeley Jaishri , Ostrow Kimberly , Largaespada David , Plotkin Scott R. , Stemmer-Rachamimov Anat , Ferrer Marcela Maria , Pugh Trevor J. , Aldape Kenneth D. , Papi Laura , Zadeh Gelareh 
Published: October 2020

AbstractSchwannomatosis (SWNTS) is a genetic cancer predisposition syndrome that manifests as multiple and often painful neuronal tumors called schwannomas (SWNs). While germline mutations in SMARCB1 or LZTR1, plus somatic mutations in NF2 and loss of heterozygosity in chromosome 22q have been identified in a subset of patients, little is known about the epigenomic and genomic alterations that drive SWNTS-related SWNs (SWNTS-SWNs) in a majority of the cases. We performed multiplatform genomic analysis and established the molecular signature of SWNTS-SWNs. We show that SWNTS-SWNs harbor distinct genomic features relative to the histologically identical non-syndromic sporadic SWNs (NS-SWNS). We demonstrate the existence of four distinct DNA methylation subgroups of SWNTS-SWNs that are associated with specific transcriptional programs and tumor location. We show several novel recurrent non-22q deletions and structural rearrangements. We detected the SH3PXD2A-HTRA1 gene fusion in SWNTS-SWNs, with predominance in LZTR1-mutant tumors. In addition, we identified specific genetic, epigenetic, and actionable transcriptional programs associated with painful SWNTS-SWNs including PIGF, VEGF, MEK, and MTOR pathways, which may be harnessed for management of this syndrome.
RSA, TSA and PyC hemi-prostheses: comparing indications and clinical outcomes using a second-generation modular short-stem shoulder prosthesis
Authors: Kleim Benjamin D. , Garving Christina , Brunner Ulrich H. 
Published: October 2020

AbstractIntroductionThe goal of this study was to provide an insight into the clinical results after modular short-stem shoulder arthroplasty for various indications.Materials and methodsA consecutive cohort study of 76 patients followed up for 23–55 (mean 31.4) months. 23 anatomical (TSA), 32 reverse (RSA) and 21 hemi-prostheses with a pyrocarbon head (PyC), using a modular short stem with proximal porous coating were implanted. Range of motion, pain and Constant score (CS) were recorded. Comparisons of pre- vs postoperative outcomes, between prosthesis types and indications, were made.ResultsAll prosthesis types brought about a significant improvement (p < 0.05) in all measured outcomes. TSA had a significantly higher increase in the CS than PyC and RSA (p = 0.002 and 0.003, respectively). TSA produced superior gains in all ROM compared with RSA (p < 0.02). RSA brought about significantly smaller improvements in internal rotation than TSA and PyC (p = 0.0001 and 0.008, respectively). TSA had greater pain relief than PyC (p = 0.02). TSA with Walch A glenoids seemed to improve more than type B in the CS. PyC patients with Walch B glenoids improved more than Walch A (p = 0.03). When implanted due to Osteoarthritis (OA), PyC had a comparable final outcome to TSA (p = 0.95), although the preoperatively worse TSA patients had a greater improvement in the CS (p = 0.026). The outcome of RSA did not differ between indications, but Walch A glenoids tended to improve more.ConclusionsUsing a second-generation short-stem shoulder prostheses, TSA achieves the best clinical improvements overall, especially for OA with a Walch A glenoid. Despite refixation of the subscapularis tendon in all cases, RSA has inferior internal rotation than TSA and PyC, suggesting a mechanical limitation. OA, a Walch B glenoid and arthritis caused by instability seem to be ideal indications when considering PyC.
A cluster analysis describing spine and torso shape in Lenke type 1 adolescent idiopathic scoliosis
Authors: Gardner Adrian , Berryman Fiona , Pynsent Paul 
Published: October 2020

AbstractPurposeThe purpose of this work is to identify the variability and subtypes of the combined shape of the spine and torso in Lenke type 1 adolescent idiopathic scoliosis (AIS).MethodsUsing ISIS2 surface topography, measures of coronal deformity, kyphosis and skin angulation (as a measure of torso asymmetry) in a series of children with Lenke 1 convex to the right AIS were analyzed usingk-means clustering techniques to describe the combined variability of shape in the spine and torso. Following this, ak-nearest neighbor algorithm was used to measure the ability to automatically identify the correct cluster for any particular datum.ResultsThere were 1399 ISIS2 images from 691 individuals available for analysis. There were 5 clusters identified in the data representing the variability of the 3 measured parameters which included mild, moderate and marked coronal deformity, mild, moderate and marked asymmetry alongside normal and hypokyphosis. Thek-nearest neighbor identification of the correct cluster had an accuracy of 93%.ConclusionThese clusters represent a new description of Lenke 1 AIS that comprises both coronal and sagittal measures of the spine combined with a measure of torso asymmetry. Automated identification of the clusters is accurate. The ability to identify subtypes of deformity, based on parameters that affect both the spine and the torso in AIS, leads to as better understanding of the totality of the deformity seen.