bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic reliability assessment and the nonergodicity in the modelling parameter uncertainties
Authors: Jalayer Fatemeh , Ebrahimian Hossein 
Published: January 2020

SummaryModelling uncertainty can significantly affect the structural seismic reliability assessment. However, the limit state excursion due to this type of uncertainty may not be described by a Poisson process as it lacks renewal properties with the occurrence of each earthquake event. Furthermore, considering uncertainties related to ground motion representation by employing recorded ground motions together with modelling uncertainties is not a trivial task. Robust fragility assessment, proposed previously by the authors, employs the structural response to recorded ground motion as data in order to update prescribed seismic fragility models. Robust fragility can be extremely efficient for considering also the structural modelling uncertainties by creating a dataset of one‐to‐one assignments of structural model realizations and as‐recorded ground motions. This can reduce the computational effort by more than 1 order of magnitude. However, it should be kept in mind that the fragility concept itself is based on the underlying assumption of Poisson‐type renewal. Using the concept of updated robust reliability, considering both the uncertainty in ground motion representation based on as‐recorded ground motion and non ergodic modelling uncertainties, the error introduced through structural reliability assessment by using the robust fragility is quantified. It is shown through specific application to an existing RC frame that this error is quite small when the product of the time interval and the standard deviation of failure rate is small and is on the conservative side.
Evaluation of the going‐concern status for companies: An ensemble framework‐based model
Authors: Hsu Yu‐Feng , Lee Wei‐Po 
Published: January 2020

AbstractIssuing a going‐concern opinion is a difficult and complex task for auditors. The auditors have to take into account different critical factors in order to make the right decision based on information obtained from the auditing process. This study adopts the so‐called “random forest” approach (based on the ensemble method) to assist auditors in making such a decision. To investigate the corresponding effect of the proposed approach, we conduct a series of experiments and a performance comparison. The results show that the random forest method outperforms the baseline methods in terms of the accuracy rate, ROC area, kappa value, type II error, precision, and recall rate. The proposed approach is proven to be more accurate and stable than previous methods.
Gastrodin improves preeclampsia‐induced cell apoptosis by regulation of TLR4/NF‐κB in rats
Authors: Mei Zhixiong , Huang Baoqin , Qian Xialiu , Zhang Yuan , Teng Benqi 
Published: January 2020

AbstractTo explain gastrodin improved cell apoptosis induced by preeclampsia in vivo and in vitro study. The PE and normal rats were injected with normal saline (Model), low‐dose gastrodin (Gas‐L), medium‐dose gastrodin (Gas‐M), and high‐dose gastrodin (Gas‐H) groups at 50, 100, or 200 mg/kg per day. The rat blood pressure and 24‐hr urine protein level were measured at pregnant days 10, 16, and 20. Evaluating pathology by H&E staining, the cell apoptosis by TUNEL, and MyD88 and NF‐κB (p65) proteins by IHC assay using H/R to simulate PE cell model. Measuring cell proliferation, apoptosis, and MyD88 and NF‐κB (p65) protein expression by MTT, flow cytometry, and WB assay. The SBP, DBP, and 24‐hr urine protein levels were significantly different in PE rats (p < .05). The SBP, DBP, and 24‐hr urine protein levels were significantly improved (p < .05) in vivo and in vitro. The positive apoptosis cells and apoptosis rate were significantly increased with MyD88 and NF‐κB (p65) proteins upregulation (p < .05). The positive apoptosis cells and apoptosis rate were significantly decreased with MyD88 and NF‐κB (p65) proteins depressing in gastrodin‐treated groups with dose‐dependent (p < .05). Gastrodin improves PE‐induced cell apoptosis and pathology changed via MyD88/NF‐κB pathway in vitro and in vivo study.
Effects of corn syrup solids containing maltobionic acid (maltobionic acid calcium salt) on bone resorption in healthy Japanese adult women: A randomized double‐blind placebo‐controlled crossover study
Authors: Suehiro Daiki , Nishio Ayaka , Kawai Junya , Fukami Ken , Ohnishi Motoko 
Published: January 2020

AbstractMaltobionic acid is known to have an inhibitory effect on the differentiation of osteoclasts, and it has also been reported in an intervention trial that ingestion of corn syrup solids containing maltobionic acid maintained and increased the bone density of postmenopausal women. However, there is no information on whether maltobionic acid improves bone metabolism in humans. Therefore, we evaluated the influence of corn syrup solids containing maltobionic acid (maltobionic acid calcium salt) on bone resorption markers in healthy Japanese women. Forty‐one individuals were selected from 68 participants and assigned to two groups: 21 individuals in the test food antecedent group and 20 individuals in the placebo food antecedent group; individuals in the first group ingested 4 g of corn syrup solids containing maltobionic acid, and subjects in the second group ingested 4 g of placebo (hydrous crystalline maltose and calcium carbonate) for 4 weeks. Bone resorption marker levels (DPD and u‐NTx) were evaluated by urinalysis. Forty subjects completed the study, and no adverse events related to the test food were observed. Fourteen subjects were excluded prior to the efficacy analysis because of conflict with the control criteria; the remaining 33 subjects were analyzed. Consumption of corn syrup solids containing maltobionic acid was maintained; DPD and u‐NTx values were improved (p < .05). These results indicate that corn syrup solids containing maltobionic acid might contribute to suppress bone resorption and improve bone metabolism in postmenstrual women. (UMIN‐CTR ID: UMIN000034257; Foundation: San‐ei Sucrochemical Co., Ltd.).
Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little‐studied population
Authors: Almajwal Ali Madi , Alam Iftikhar , Abulmeaty Mahmoud , Razak Suhail , Pawelec Graham , Alam Wajid 
Published: January 2020

AbstractDietary advanced glycation end products (dAGE) have profound negative effects on overall health, and their intake must be assessed. In this cross‐sectional study, we investigated dAGE intake of 337 adult participants (180/157:M/F; age range 50–73 years). Data were collected on anthropometrics, body composition, dietary intake, selected blood biochemistry, immunological parameters, and antiradical capacity (50% hemolysis time; HT50). From the dietary data, dAGEs and phytochemical index (PI) were calculated. Mean BMI, % body fat (%BF), and fasting plasma glucose were all within the accepted normal range. Subjects with high dAGE intake had higher %BF, higher energy intake, and lower PI. They tended to have lower CD4/CD8 ratios and higher proportions of B cells and NK cells, but had significantly higher hs‐CRP levels and lower HT50 values. Results on HT50 suggested that being >60 years of age enhanced dAGE‐associated impairment of defense capacity in both those with low and high HT50 compared with those <60 years of age. Thus, overall dAGE consumption was high, but elderly participants had lower dAGE intake than younger adults. Indicators of nutritional status and immunological parameters of the subjects were found to be associated with dAGE intake, suggesting a potential impact on health.
Perceived value drives use of routine asymptomatic surveillance PET/CT by physicians who treat head and neck cancer
Authors: Roman Benjamin R. , Lohia Shivangi , Mitra Nandita , Wang Marilene B. , Pou Anna M. , Holsinger F. Christopher , Myssiorek David , Goldenberg David , Asch David A. , Shea Judy A. 
Published: January 2020

AbstractBackgroundWhy physicians use surveillance imaging for asymptomatic cancer survivors despite recommendations against this is not known.MethodsPhysicians surveilling head and neck cancer survivors were surveyed to determine relationships among attitudes, beliefs, guideline familiarity, and self‐reported surveillance positron‐emission‐tomography/computed‐tomography use.ResultsAmong 459 responses, 79% reported using PET/CT on some asymptomatic patients; 39% reported using PET/CT on more than half of patients. Among attitudes/beliefs, perceived value of surveillance imaging (O.R. 3.57, C.I. 2.42‐5.27, P = <.0001) was the strongest predictor of high imaging, including beliefs about outcome (improved survival) and psychological benefits (reassurance, better communication). Twenty‐four percent of physicians were unfamiliar with guideline recommendations against routine surveillance imaging. Among physicians with high perceived‐value scores, those less familiar with guidelines imaged more (O.R. 3.55, C.I. 1.08‐11.67, P = .037).ConclusionsInterventions to decrease routine surveillance PET/CT use for asymptomatic patients must overcome physicians' misperceptions of its value. Education about guidelines may modify the effect of perceived value.
Influence of Hall current on hydromagnetic natural convective flow between two vertical concentric cylinders in presence of heat source/sink
Authors: Dwivedi Naveen , Kumar Singh Ashok 
Published: January 2020

AbstractThe fully developed laminar magnetohydrodynamic free convection between two concentric vertical cylinders with Hall currents and heat source/sink, in the presence of the radial magnetic field, are studied. The governing thermal energy and momentum equations are changed into ordinary differential equations whose solutions are determined in closed‐form expressions of the Bessel and modified Bessel functions of order zero. A parametric investigation illustrating the impacts of the Hall current, magnetic field, heat source, and radii ratio has been accomplished graphically to examine the changes in temperature as well as velocity while the Nusselt number, mass flux, and skin friction values have been presented in tabular forms. The results ensure that the Hall current has a strong and direct impact on the flow character, such that the influence of the Hall parameter enhances the velocity fields in the appearance of heat source and sink. The velocity remains almost constant as the Hall parameter value is greater than four. Moreover, the velocity and temperature fields have an increasing tendency due to the heat source and inversely for the heat sink.
Modifying the Jackson index to quantify the relationship between geology, landscape structure, and water transit time in steep wet headwaters
Authors: Gabrielli Christopher P. , McDonnell Jeff J. 
Published: January 2020

AbstractThe relationship between stream water mean transit time (MTT), catchment geology, and landscape structure is still poorly characterized. Here, we present a new simple index that builds on the Jackson, Bitew, and Du (2014) index that focuses specifically on permeability contrasts at the soil–bedrock interface and digital elevation model‐based physical flow path measurements to identify broad landscape trends of moisture redistribution in the subsurface of steep wet headwater catchments. We use this index to explore the relationship between geology, landscape structure, and water transit time through the lens of landscape anisotropy. We hypothesize that catchments with a greater tendency to shed water laterally will correlate with younger stream water MTT and catchments with a greater tendency to infiltrate water vertically will correlate with older stream water MTT. We tested the new index at eight geologically diverse Pacific Rim catchments in Oregon, Japan, and New Zealand. The new index explained 77% of the variability in measured stream water MTT across these varied sites. These findings suggest that critical zone anisotropy and catchment form are first‐order controls on the time scales over which catchments store and release their water and that a simple index may usefully capture this relationship.
Temperament is associated with the use of communicative gestures in infancy
Authors: Ollas Denise , Rautakoski Pirkko , Nolvi Saara , Karlsson Hasse , Karlsson Linnea 
Published: January 2020

AbstractTemperament is important to consider when investigating factors influencing communicative development in infancy. Existing research supporting the assumption that temperament and verbal language development are interrelated covers mainly verbal development in toddlerhood onward, but few studies focus on these relations in infancy. The present study of 91 infants from a general population pregnancy cohort in Finland used parent reports to investigate associations between temperament and the development of preverbal gesturing and receptive vocabulary in infancy. We found that infant temperament explained a substantially larger proportion of the variance in expressive communicative gesturing compared to receptive vocabulary. High Duration of orienting and Soothability, indicators of orienting/regulation capacity, and higher positive emotionality were found to be favourable for the use of communicative gestures. These temperament characteristics might promote interaction and thus advance communicative development. Knowledge on associations between infant temperament and communicative development is important in supporting outcomes in children with temperament characteristics possibly less favourable for communication development.Highlights

The aim is to investigate how temperament traits relate to gesture use and receptive vocabulary in infants.
Temperament was assessed at 6 and 12 months and receptive vocabulary and gesture use at 12 months using parental reports.
Temperament was found to relate to communicative development in infancy, and to use of communicative gestures in particular.
Spindle cell renal cell carcinoma diagnosed after sunitinib treatment for chromophobe renal cell carcinoma
Authors: Honda‐Takinami Ruriko , Ishibashi Kei , Onagi Akifumi , Tanji Ryo , Matsuoka Kanako , Hoshi Seiji , Koguchi Tomoyuki , Hata Junya , Yabe Michihiro , Sato Yuichi , Akaihata Hidenori , Kataoka Masao , Ogawa Soichiro , Haga Nobuhiro , Kojima Yoshiyuki 
Published: January 2020

IntroductionChromophobe renal cell carcinoma presents in early pathological stages with a lower risk of metastasis. However, aggressive features and metastasis can occur. A rare case of rapidly progressive disease with histological changes is presented.Case presentationA 56‐year‐old woman had a right renal tumor with multiple lymph node metastases, and the pathological diagnosis of the biopsy specimens from the primary tumor was chromophobe renal cell carcinoma. After sunitinib treatment, the metastatic lymph node had decreased in size and the numbers of circulating tumor cells were decreased, consequently, cytoreductive nephrectomy was performed. However, rapid progression of lymph node metastases was observed. Histopathological examination showed that the renal tumor was diagnosed as spindle cell renal carcinoma.ConclusionIt appears that the primary tumor underwent epithelial‐mesenchymal transition; further tissue specimen collection and analysis might be needed.
Pollen morphology of Chinese Pseudostellaria (Caryophyllaceae) and its systematic significance
Authors: Cui Xinci , Hu Ziming , Ren Simin , Liu Jiaxi 
Published: January 2020

AbstractUsing light and scanning electron microscopy, we studied the pollen morphology of six species (one of which are endemic) of Chinese Pseudostellaria. All species were studied for the first time. Results of this study indicated that pollen grains of Pseudostellaria are spheroidal or spheroidal‐polyhedral in shape and small or medium in size and pantoporate. Each pollen grain has 12–16 round pores. These pores are apart from each other by 5.77–7.73 μm and each has 7–13 granules in the operculum region. These features have important taxonomic significance. In addition, their pollen grains have thin exine with microechinate‐punctate‐perforate surface ornamentation. Pollen features do not support the traditional infrageneric classification of Pseudostellaria into two sections, but support that Pseudostellaria is closely related to other species of the Odontostemma clade.
High‐Grade Soft‐Tissue Sarcomas: Can Optimizing Dynamic Contrast‐Enhanced MRI Postprocessing Improve Prognostic Radiomics Models?
Authors: Crombé Amandine , Fadli David , Buy Xavier , Italiano Antoine , Saut Olivier , Kind Michèle 
Published: January 2020

BackgroundHeterogeneity on pretreatment dynamic contrast‐enhanced (DCE)‐MRI of sarcomas may be prognostic, but the best technique to capture this characteristic remains unknown.PurposeTo investigate the best method to extract prognostic data from baseline DCE‐MRI.Study TypeRetrospective, single‐center.PopulationFifty consecutive uniformly‐treated adults with nonmetastatic high‐grade sarcomas.Field Strength/Sequence1.5T; T2‐weighted‐imaging, fat‐suppressed fast spoiled gradient echo DCE‐MRI.AssessmentNinety‐two radiomics features (RFs) were extracted at each DCE‐MRI phase (11, from t = 0–88 sec). Relative changes in RFs (rRFs) since the acquisition baseline were calculated (11 × 92 rRFs). Curves of rRF as function of time postinjection were integrated (92 integrated‐rRFs [irRFs]). Ktrans and area under the time–intensity curve at 88‐sec parametric maps were computed and 2 × 92 parametric‐RFs (pRFs) were extracted. Five DCE‐MRI‐based radiomics models were built on: an RFs subset (32 sec, 64 sec, 88 sec); all rRFs; all irRFs; and all pRFs. Two models were elaborated as reference, on: conventional radiological features; and T2‐WI RFs.Statistical TestsA common machine‐learning approach was applied to radiomics models. Features with P < 0.05 at univariate analysis were entered in a LASSO‐penalized Cox regression including bootstrapped 10‐fold cross‐validation. The resulting radiomics scores (RScores) were dichotomized per their median and entered in multivariate Cox models for predicting metastatic relapse‐free survival. Models were compared with integrative area under the curve (AUC) and concordance index.ResultsOnly dichotomized RScores from models based on rRFs subset, all rRFS and irRFS correlated with prognostic (P = 0.0107–0.0377). The models including all rRFs and irRFs had the highest c‐index (0.83), followed by the radiological model. The radiological model had the highest integrative AUC (0.87), followed by models including all rRFs and irRFs. The radiological and full rRFs models were significantly better than the T2‐based radiomics model (P = 0.02).Data ConclusionThe initial DCE‐MRI of STS contains prognostic information. It seems more relevant to make predictions on rRFs instead of pRFs.Evidence Level: 3Technical Efficacy: 3J. Magn. Reson. Imaging 2020;52:282–297.
On the devil's tracks: unexpected news from the Foresta ichnosite (Roccamonfina volcano, central Italy)
Authors: Panarello Adolfo , Palombo Maria Rita , Biddittu Italo , Di Vito Mauro Antonio , Farinaro Gennaro , Mietto Paolo 
Published: January 2020

ABSTRACTThe Foresta ichnosite is well known for preserving some of the oldest human fossil footprints recorded in Europe so far. This research aims to: i) describe new footprints that are larger than those already reported, some of which form a new trackway that moves in the opposite direction to all the others; ii) announce the discovery of some stone tools also in the surroundings of the Foresta ichnosite. The new results increase the total number of human fossil footprints to at least 81, specify the direction and the number of footprints of Trackway C, and identify three new directions of walking at the site. More compelling and complete estimates of the dimensional range of all ichnological evidence enables us, furthermore, to estimate the number of trackmakers walking on the trampled surface as a minimum of five, one of them likely being an adult male. The general shape of all the recorded footprints suggests that the Foresta trackmakers share some similarities with those at Sima de los Huesos, and belong to the same taxonomical group as the Ceprano skull. All the new evidence enables us to better understand the presence of hominin populations in the Roccamonfina volcano area during the Middle Pleistocene. © 2020 John Wiley & Sons, Ltd.
Emerging Trends in Nasal Surgery: What Is the Impact of a Bioabsorbable Nasal Implant?
Authors: Ge Marshall , Kim Jee‐hong , Wrobel Bozena , Smith Stephanie Shintani , Kochhar Amit , Ference Elisabeth H. 
Published: January 2020

BackgroundA bioabsorbable nasal valve implant (NVI) was introduced in 2016 as a minimally invasive solution to nasal valve collapse. Historically the introduction of less invasive procedures performable in‐office has resulted in an increase in volume. Our objective is to evaluate this trend as it relates to nasal vestibular repair, and its impact on healthcare utilization.MethodsWe interrogated the Medicare Part B national database for nasal vestibular repair (CPT code: 30465), Unlisted nasal procedure (30999) and septoplasty (30520) from 2010 to 2017. Septoplasty was used as a surrogate for overall nasal procedural rate. Linear regression modeling was used to examine the changes in reported vestibular repair rate adjusting for septoplasty rate.ResultsIn the Medicare population, the rate of septoplasty was stable from 2010 to 2017, increasing from 26,962 to 30,194 at an annual rate of 1.5%. Coding for unlisted nasal procedure increased from 272 to 333 at an adjusted annual rate of 1.1% over this time period. Coding for nasal vestibular repair increased from 2026 to 5331 over this interval at an adjusted annual rate of 0.9% from 2010 to 2016 but significantly increased to 5% between 2016 to 2017 (P < .0001).ConclusionThe reported volume of nasal vestibular repair increased significantly in the year following Food and Drug Administration approval of NVIs. In the absence of a corresponding increase in septoplasty, this temporal relationship suggests that the introduction of NVIs impacted the utilization of this procedural code.Level of EvidenceN/ALaryngoscope, 2020
Efficacy and Influence Factors of 308‐nm Excimer Lamp with Minoxidil in the Treatment of Alopecia Areata
Authors: Li Anqi , Meng Xianfu , Xing Xiaojing , Tan Hong , Liu Junlian , Li Chengxin 
Published: January 2020

Background and ObjectivesAlopecia areata (AA) is an autoimmune disease characterized by T cell‐mediated attack on the hair follicle. Although there are a wide range of therapies, the majority of them are not satisfactory due to side effects or limited efficacy. In this study, we sought to evaluate the efficacy, influence factors, and safety of 308‐nm excimer lamp with minoxidil in the treatment of AA.Study Design/Materials and MethodsThis was a prospective, single‐blinded, self‐control study, using 308‐nm excimer lamp with minoxidil for the treatment of AA. One selected alopecia lesion was divided into the control and treated side. Topical minoxidil (2% solution) was used on both sides, but 308‐nm excimer lamp was only added to the treated side. The primary endpoint was the discrepancy of hair growth on each side.ResultsA total of 38 patients (24 males and 14 females) with AA were enrolled in this study, and 34 of them (21 males and 13 females) completed the whole treatment. Thirty‐two (94.2%) patients achieved clinical response, and 21 (44.1%) patients achieved with >50% hair regrowth on the treated side after a 12‐week treatment. The hair number and diameter on the treated side had significantly increased compared with the control side with statistical differences. Hyperpigmentation and erythema occurred on the treated side of all the patients but they were considered tolerable. Patients of younger age or with smaller area of lesion had better effect.ConclusionsThe 308‐nm excimer lamp with minoxidil therapy can be considered as an effective and safe treatment for single or multiple AA. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.