bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presumed acquired neuromyotonia of unknown cause in a cat with hyperthyroidism
Authors: Santifort Koen M , Vanhaesebrouck An , Bashford James , Van Soens Iris 
Published: December 2024

Case summary A 16-year-old spayed female domestic shorthair cat with methimazole-treated hyperthyroidism presented with a chronic progressive history of a stiff gait progressing to recumbency. A neurological examination revealed continuous excessive muscle tone with myokymia, which exacerbated with exercise and persisted during general anaesthesia. An electromyographic study revealed myokymic discharges in all tested muscles, as well as complex repetitive discharges, fibrillation potentials and positive sharp waves. Blood tests, urinalysis and abdominal ultrasound did not reveal significant abnormalities. A histological examination of a muscle biopsy showed no specific abnormalities. A clinical diagnosis of acquired neuromyotonia with myokymia was formulated. Phenytoin treatment resulted in temporary improvement, but excessive muscle tone recurred resulting in episodes of dyspnoea. Euthanasia was elected 3 weeks after presentation. Relevance and novel information To the best of the authors’ knowledge, this is the second report of an acquired neuromyotonia in a cat. In contrast with the previous report, treatment with phenytoin resulted in only partial and temporary improvement of signs. Subsequent progression of the disease, including signs of dyspnoea and dysuria, led to the decision to euthanase the cat. In humans, acquired neuromyotonia (Isaacs syndrome) is usually due to an autoimmune response to proteins associated with voltage-gated potassium channels. More rarely, it has also been described in humans with thyroid disorders. A link with methimazole treatment or hyperthyroidism in the cat reported here could not be excluded.
Perceived Health Concerns and Barriers to Care in Persons With Overweight and Obesity: A Patient Survey
Authors: Keller A. Scott , Hurt Ryan T. , Schroeder Darrell R. , DeJesus Ramona S. , Ganesh Ravindra , Fokken Shawn C. , Mundi Manpreet S. , Bonnes Sara L. , Lawson Donna K. , Njeru Jane W. , Vincent Ann , Ebbert Jon O. , Ghosh Karthik , Abu Lebdeh Haitham S. , Hensrud Donald D. , Nanda Sanjeev , Croghan Ivana T. 
Published: December 2024

Objectives: To identify patient characteristics, health concerns, and barriers to care based on overweight or obesity. Methods: A 50-question anonymous survey was administered to patients. Data were compared by body mass index (BMI). Results: Among 3976 distributed surveys, 899 were returned and 682 were analyzed. Most respondents were women (60%), White (94%), and married/partnered (65%) and had some college education (80%). Younger and unmarried persons had higher BMI ( P < .001). Concern for quality of life ( P < .001) and importance of lifestyle changes ( P = .006) increased with BMI, but confidence in making changes decreased as BMI increased ( P < .001). Perceived good health decreased with increasing BMI ( P < .001), whereas depression and other comorbid conditions increased. Self-esteem decreased and stigma increased with higher BMI (both P < .001). Weight discussions with clinicians ( P < .001) and belief that clinicians should be involved in weight management ( P = .002) increased with BMI, yet self-perception of being judged by clinicians also increased ( P < .001). As BMI increased, delays in seeking health care increased ( P < .001). Conclusions: This survey study highlights perceived health concerns and barriers to care among persons with overweight and obesity. With higher BMI, self-esteem decreased, and stigma, self-perception of poor health, perception of being judged by clinicians, and delay in seeking medical care increased.
Fear of Crime During Years of Street Violence Is Associated With Worsening Cardiovascular Health Status
Authors: Del Brutto Oscar H. , Mera Robertino M. , Del Brutto Victor J. , Rumbea Denisse A. , Arias Emilio E. , Sedler Mark J. 
Published: December 2024

Background: Street violence has detrimental effects on cardiovascular health (CVH). However, the significance of these consequences have not been systematically evaluated. In this study, we aimed to assess the impact of fear of crime on CVH status among community-dwellers aged ≥40 years living in a rural village stricken by violence. Methods: Participants were selected from individuals enrolled in the Atahualpa Project Cohort, a population-based longitudinal study that aims to reduce the burden of cardiovascular risk factors and diseases in rural Ecuador. Fear of crime was evaluated using a structured scale. The Life’s Simple 7 construct of the American Heart Association was employed to assess CVH before the escalation of violence and crime in the village (2019) and at the end of the study (2024). Multivariate logistic regression models were fitted to examine the association between the exposure and outcomes. Results: A total of 648 individuals (mean age = 57.4 ± 11.7 years; 56% women) were included. At the end of the follow-up, significant association between fear of crime levels and worsening CVH status was noted. Participants allocated to the second and third tertiles of fear of crime were 3.27 (95% CI = 2.07-5.19) and 5.46 (95% CI = 3.14-9.48) times more likely to have worsening CVH status at follow-up compared to baseline determinations, respectively. Conclusion: This study shows an aggravating impact of fear of crime on the CVH status and identifies interventional targets that may help to reduce the risk of CVH status worsening in community-dwellers living in rural settings afflicted by violence.
The assistive gait devices and their implementation in activities of daily living for patients with neuromuscular disease: A systematic review and meta-analysis
Authors: Mijic Marko , Wirner-Piotrowski Corinna , Jung Andres , Gutschmidt Kristina , Arndt Marcela , García-Angarita Natalia , Wenninger Stephan , Young Peter , Schoser Benedikt 
Published: December 2024

Background: To date, assistive gait devices (AGDs) for people with neuromuscular diseases (NMDs) have not been systematically evaluated. Objective: This systematic review evaluated AGDs for people with NMDs. Methods Suitable tools were used to assess the study quality and the certainty of evidence. If feasible, a descriptive and quantitative synthesis was conducted. Results: Forty studies were included on: gait-assisting exoskeletons (GAEs), orthopaedic footwear (OF), knee and/or ankle-foot-orthoses (AFOs) and non-invasive neuroprostheses that provide functional electrical stimulation (FES). Pairwise meta-analysis could not be performed due to a lack of homogenous data. The within-group pre-post meta-analysis in GAE studies showed an improvement in 2-min walk test (2MWT) (m) (standardized mean difference [SMD] = 0.36, 95%-CI: 0.17 to 0.54), but not in 10-meter walk test (10MWT) (sec) (SMD = 0.33, 95%-CI: −0.10 to 0.76) and in functional independence measure (FIM) (SMD = −0.002, 95%-CI: −0.21 to 0.21). In AFO studies, there was no improvement in 10MWT(m) (SMD = −0.11, 95%-CI: −0.76 to 0.53). A single session with AFO or OF vs no-AFO or OF post-intervention meta-analysis did not reveal an improvement in walking speed (m/s) (SMD = 0.39, 95%-CI: −0.03 to 0.83). Discussion: GAEs seem to help patients to walk longer. The meta-analyses showed no significant results to support the effect of AFOs or OF. Neuroprostheses and knee orthoses showed no evidence. Conclusion: No clear conclusions can be drawn on how AGDs affect NMDs. The positive AGD effects are based on very low certainty of evidence.
Mutational and clinical spectrum of myofibrillar myopathy in one center from China
Authors: Wang Qi , Sun Peng , Yu Meng , Xie Zhiying , Yu Jiaxi , Liu Xiujuan , Hong Daojun , Lv He , Deng Jianwen , Yuan Yun , Wang Zhaoxia , Zhang Wei 
Published: December 2024

Background: Myofibrillar myopathy (MFM) is a heterogeneous group of neuromuscular disorders characterized by degeneration of Z-disk and disintegration of myofibrils. OBJECTIVE: We aimed to analyze the mutational spectrum and phenotypic features of MFM in China. Methods: We used targeted next generation sequencing (NGS) to identify causative mutations in 39 MFM patients with confirmed myopathological diagnosis. Results: The results showed that variants were found in six MFM-associated genes, including DES, FLNC, BAG3, MYOT, TTN and DNAJB6, in 28 (71.7%), 3 (7.7%), 3 (7.7%), 1 (2.6%), 3 (7.7%), and 1 (2.6%), respectively. Of the total 26 variants identified, 19 were reported previously and 7 were novel variants. Missense variant (80.0%) was the most common mutant type of DES. P209L was the hotspot mutation of BAG3 while no obvious hotspot mutation was found of DES. Clinically, distal and proximal weakness were observed in 64.1% and 35.9% patients. Arrythmia and peripheral neuropathy were the most common combined symptoms of desminopathy and BAG3opathy, respectively. Pathologically, rimmed vacuoles (RVs) were present in different genetic type of MFM. Giant axonal nerve fiber was found in BAG3-releated MFM patient. Conlusion: We concluded that MFM showed a highly variable genetic spectrum, with DES as the most frequent causative gene followed by FLNC, BAG3 and TTN. This study expanded the genotypic and phenotypic spectrum of MFM among Chinese cohort.
The telemedical platform MyaLink for remote monitoring in myasthenia gravis – rationale and protocol for a proof of concept study
Authors: Stein Maike , Meisel Andreas , Mönch Maximilian , Narayanaswami Pushpa , Sun Haoqi , Herdick Meret , Gerischer Lea , Lehnerer Sophie 
Published: December 2024

Rationale: Myasthenia gravis (MG) is a rare, chronic neurological disorder leading to fluctuating muscle weakness and potentially life-threatening crises. Patients often require life-long specialized treatment, but timely interventions are frequently hindered by the limited availability of specialists. Telemedical solutions at specialized centers enabling patient-physician interaction hold promise in bridging this gap, but are not yet available for MG. We developed ‘MyaLink,’ a remote monitoring platform tailored for MG, and outline the study design assessing the platform and clinical outcomes regarding telemedical intervention. Additionally, we present study results on care-related aspects in MG prior to telemedical intervention to identify challenges in the current care provision process. Design: The platform comprises a patient app and a physician portal, enabling systematic symptom monitoring using data from patient-reported outcome measures (PROMs), coupled devices and a communication module. The randomized controlled study included 45 study participants (SP) over a 12-weeks period, including a group receiving standard care (15 MG patients) and a group with additional telemedical treatment (30 MG patients) including assessment of PROMs, wearable data collection and telemedical check-ups. Questions regarding care-related aspects were assessed at baseline visit. Results: Many SP (N = 33, 73.3%) communicate with the physician managing their MG via email. 73.3% (N = 33) of SP identify areas for improvement in their MG care including symptom monitoring (N = 23, 69.7%), specialist appointment availability (N = 22, 66.7%), medication (N = 22, 66.7%) and specialist accessibility (N = 20, 60.6%). Additionally, 73.3% (N = 33) reported that the effort required to manage their MG was high. Conclusion: Our results emphasize the high demand of affected MG patients for continuous telemedicine services. MyaLink can provide such a service through personalized support based on the exchange of health data. Telemedicine solutions such as MyaLink promise to improve myasthenia care by providing accessible, patient-centred care that enables early detection of worsening symptoms and non-response to treatment. Trial registration: The study was registered under DRKS00029907 on August 19, 2022.
Development and characterisation of a large animal transgenic tumor model for sarcomatoid renal cell carcinoma
Authors: Rice Samuel L , Kapur Payal , Alnablsi Mhd Wisam , De Las Casas Luis , Osborne Joseph R , Beets-Tan Regina 
Published: December 2024

Background Sarcomatoid (and rhabdoid) dedifferentiation can occur in ∼5% of renal cell carcinomas (sRCC), a finding with significant therapeutic implications. sRCC is associated with increased aggressiveness, resistance to conventional targeted therapies, and increased sensitivity to immune checkpoint inhibitors. Objective There are no preclinical models for sRCC that can be used in research to better understand this disease. The pig has similar size, anatomy, immune system, and genetics, that can be employed to evaluate procedures or tumor specific drugs. We report on the creation of a large animal porcine model for sRCC. Materials In eight Oncopigs, a Cre-recombinase gene adenoviral vector (AdCre) was incubated with renal tissue obtained from an ultrasound (US) percutaneous biopsy and reinjected into the renal cortex. US was performed to assess growth and to obtain tumor tissue for pathologic and immunohistochemistry evaluation. Results Three weeks post inoculation renal tumors were successfully formed in 28 out of 32 sites (88%). Mean tumor size by imaging was 1.6 × 1.1 cm (range: 0.4–3.9 cm longest axis). Pigs remained clinically healthy up to 25 days after inoculation. On histology, tumors consisted of foci of infiltrating sarcomatoid and rhabdoid cells in a background of marked acute and chronic inflammation. The neoplastic cells showed positive immunoreactivity for PAX8, cytokeratin AE1/AE3 supporting a renal tubular origin. These cells were diffusely positive for p53 and showed high ki-67 (20–30%), and cleaved caspase 3 (20–30%) expression. Conclusion Rapid growing poorly differentiated neoplasms associated with a marked inflammatory reaction that have phenotypic and immunohistochemical features of sRCC were successfully developed. These may be suitable to study the response to local and systemic therapies.
Visualizing Aphasia in Linguistics From 2000 to 2019
Authors: Wang Huili , Zhang Shurong , Guo Hanning , Liu Bo 
Published: December 2024

Abstract
This paper aims to visualize the research of aphasia from a linguistic perspective for the two decades from 2000 to 2019, identifying the changes in research focus and the future emerging trends of aphasia studies in linguistics. Applying the bibliometric approach, the present study reviewed 3,004 publications with the topic word “aphasia” in the framework of linguistics. The dataset was created from the Web of Science database ranging from 2000 to 2019. Using the CiteSpace tool, document co-citation analysis, betweenness centrality (BC) measurement and citation burst detection were conducted to explore and determine the thematic patterns, critical studies, and emerging trends of this knowledge domain. Twelve thematic patterns in these two decades were identified, indicating that researchers have focused on language impairment in aphasia, aphasia therapy and other topics associated with aphasia. Meanwhile, papers with high BC reveal the connections among different research clusters. In addition, bursts of detected citations demonstrate that treatment aiming at the enhanced quality of daily life, the utilization of discourse tasks and treatments at the discourse level, deeper exploration of primary progressive aphasia in terms of clinical data and the application of working memory assessment, and the role of working memory (WM) training in rehabilitation will possibly attract more attention in the future. On the basis of the cluster landscape, BC and citation bursts, the review found that scholars paid extensive attention to the alleviation of communication deficits in the linguistic exploration of aphasia.
Effects of stress hormones on digestibility and performance in cattle: A review
Authors: Besharati Maghsoud , Ahmad Sibtain , Jabbar Muhammad , Palangi Valiollah , Esen Selim , Esen Vasfiye Kader , Eseceli Hüseyin , Mammadov Ayaz , Lackner Maximilian 
Published: December 2024

Abstract
Various stress factors affect the physiology of cattle. Environmental stressors include heat, cold, wind, humidity, nutrition, endocrine disruptors, and management. Several negative health effects are associated with the hormones produced under stress conditions. In cattle, cortisol has been associated with reduced rates of reproduction, lowered milk production, and suppression of the immune system causing greater disease susceptibility. For a better understanding of how stress hormones impact feed digestibility and animal performance, this review has been divided into four sections (feed digestibility, milk production, milk composition, and meat quality). In dairy cows, the transition period is challenging because of a shortage of energy and nutrients, inflammation, increased lipid peroxidation, as well as hormonal and metabolic changes. Stress hormones decrease milk yield, but cortisol affects arteriovenous pressure, which is essential for milk production (due to stressful conditions or other factors such as the use of steroid medicines). Higher cortisol levels have been observed in the hotter and more stressful months of the year. On the other hand, in early lactation, reduced feed intake can lead to acidosis, reduced milk fat, and lameness in cattle. Heat stress (HS) influences milk composition negatively, especially a decrease in milk protein. In fattening animals, HS reduces feed intake, animal growth, and production efficiency. These extreme events have short-term effects and can last a day or two. Practical solutions can be adopted to reduce HS by modifying the diet, increasing the amount of water for drinking, providing shade, and a good air exchange in the barn and installing sprinklers. It is possible to increase animal welfare and product quality based on the conclusions of this review.
Heidegger’s Critical Confrontation with the Concept of Truth as Validity
Authors: Fahmy-Hooke Joshua 
Published: December 2024

Abstract
My primary goal in this article is to provide a historical reconstruction of Heidegger’s relationship to Hermann Lotze’s logic of validity (Logik der Gültigkeit). Lotze’s characterization of truth’s “actuality” solidifies the fallacious presupposition that the essence of truth is to be understood primarily in terms of logical assertions. In Heidegger’s view, the predicates “true” and “false,” as the paradigmatic attributes of propositions and judgments, are derivatives of a fundamental and “primary being of truth” known as disclosedness (Erschlossenheit). Heidegger marks this decisive position in §44 of Being and Time and gains its methodological purchase by deconstructing traditional logic (kritischer Abbau der überlieferten Logik). Heidegger’s treatment, however, is abbreviated, and his sources remain notoriously concealed. For this reason, much is to be gained by examining the supplement provided one year earlier in a lecture course titled Logic: The Question of Truth (WS 1925–26). Heidegger devotes nearly 100 pages to the contemporary situation of philosophical logic. In this course, Heidegger critically evaluates a core principle of both phenomenology and neo-Kantian Erkenntnistheorie: the concept of validity (Geltung). This term originates from Lotze’s Platonic Ideenlehre, which asserts that Platonic “ideas” correspond to thoughts through a logical necessity. Consequently, they are deemed valid and eternally self-identical but do not need to exist in the world. For the purposes of this study, I show the historical significance and influence of Lotze’s Logic on twentieth-century Neo-Kantianism and Phenomenology. I provide a detailed account of Lotze’s interpretation of the Platonic theory of ideas, which supports his theory of validity. By returning to Lotze’s text, I provide an in-depth review of Heidegger’s reading of Lotze, whom he charges with misleading twentieth-century epistemology. If successful, this article provides the necessary and historical context to understand what is left unsaid and concealed in §44 of Being and Time. This article also serves the auxiliary purpose of acting as a prolegomenon for Heidegger’s urgent return to Aristotle’s thought and accurately determining the essence of truth.
THE HOP CULTIVAR "ARDEAL" (NEW NAME OF "CLUJ SUPERALFA" CULTIVAR)
Authors: Muntean Leon Sorin , Cernea Solovastru , Morar Gavrila , Salontai Alexandru , Varban Dan Ioan , Muntean Leon , Duda Marcel Matei , Muntean Sorin , Varban Rodica , Tofana Maria 
Published: December 2024

The â€œ
Ardealâ€ hop cultivar (Humulus lupulus L., ssp europeus
Â
Ryb.) was created at
Â
â€œHop and Medicinal Plants Crop Research Centerâ€ - U.S.A.V.M. Cluj-Napoca through clonal
selection from the Hallertauer Magnum cultivar (temporarily called CN 21/96).
Among the morpho-physiological, productivity and quality features of this hop cultivar
some ought to be mentioned: it is semilate, with an average vegetation period of 138 days (90 days
- the vegetative phase and 48 days the generative phase); 35 days from the coming up until the
appearance of the lateral offshoots, 37 days until budding, flowering after 18 days, cone formation
after 28 days and reaching technological maturity after 12 days; the habitus of the plant is
cylindrical, the vines are green, the length is 8-10 m, with internodes of 15-23 cm and green
offshoots of 70-120 cm; the leaves have 3-5 dark-green lobes; the cones are oval, uniform, dense,
big, round-pointed; the blossom stem is of medium fineness, the bracts are large-medium, tightly
fixed to the stem, oval pointed yellow-green, rich in lupuline (the lupuline is orange); in yield trials
the average yields were of 2.5-2.8 t/ha dry cones; it is one of the bitter (superalfa) cultivars,
medium-flavoured, with a high content of alfa acids (13.8-14.5%); the content of alfa-acids - 340-
360 kg/ha - is much higher than that of other hop cultivars cultivated in our country; it is resistant
to mildew-powder, manna, and tolerant to aphides.
STRUCTURE OF THE HOP CULTIVARS IN THE MAIN GROWING COUNTRIES
Authors: CERNEA Solovastru , VATCA Sorin , OROS Simona 
Published: December 2024

On based of the data published by the International Hop Growers Convention. in 2010. of the 50.752 ha cultivated with hops. 24.495 ha were represented by flavored cultivars (48.2 %) și 26.297 ha bitter cultivars (51.8%). Of the total production of hops cones in that certain year. of 101.375 tons. 37.380 tons (36.0%) represent the production obtained from the flavored cultivars and 63.995 tons Â (63.1%) the total production of bitter cultivars. Germany is currently the largest growing global of aroma hop. flavored varieties accounting for 9800 ha (53.3%) of the 18.386 hectares planted with hops and Czech Republic grown solely aromatic varieties (98.5%) of the 5307 ha of hops. Important sources of aromatic hops are in Slovenia (1299 ha of the 1355 hectares planted). England (810 ha of 1080 ha). Ukraine (660 ha of 936 ha) and France (398 ha of the total of 443 hectares planted with hops ). U.S.A. with predilection cultivated rich varieties in bitter substances. especially super alpha varieties (68.7% of the 16.077 ha planted) and in China there are cultivated over 91% of the total area of hops (6023 ha) with bitter varieties.
UTILIZATION OF WATERMELON RINDS AS A NATURAL SOURCE OF ANTIOXIDANTS TO OBTAINING FUNCTIONAL FOODS
Authors: FOGARASI Melinda , TOFANA Maria , SOCACI Sonia , MURESAN Andruta , MUSTE Sevastita , SEMENIUC Cristina Anamaria , SALAGEAN Dan , TIBULCA Dorin 
Published: December 2024

Functional ingredients obtained from industrial by-products (BP) are a promising alternative for the nutritional improvement of food industry and may enhance their health promoting properties. However, the incorporation of BP functional ingredients also influences technological and sensorial properties. The main purpose of this study was to obtain a functional jam from watermelon rinds, fortified with blueberry and sea buckthorn extracts. The results show the presence of bioactive compounds (total polyphenols, antioxidant activity) in the selected fruit extracts and the obtained functional jam. It is concluded that the finished product obtained is rich in biologically active substances and minerals, being beneficial to human health.