bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twelve Hundred Consecutive Pancreato‐Duodenectomies from Single Centre: Impact of Centre of Excellence on Pancreatic Cancer Surgery Across India
Authors: Shrikhande Shailesh V. , Shinde Rajesh S. , Chaudhari Vikram A. , Kurunkar Sagar R. , Desouza Ashwin L. , Agarwal Vandana , Bhandare Manish S. 
Published: October 2019

AbstractBackgroundPancreato‐duodenectomy (PD) is a technically challenging operation with significant morbidity and mortality. Over the period of time, Tata Memorial Centre has evolved into a high‐volume centre for management of pancreatic cancer. Aim of this study is to report the short‐ and long‐term outcomes of 1200 consecutive PDs performed at single tertiary cancer centre in India.Methods1200 PDs were performed from 1992 to 2017. Prospectively maintained database was used to retrospectively assess the short‐ and long‐term outcomes.ResultsStudy cohort was divided into periods A and B (500 and 700 patients, respectively). Both groups were comparable for demographic variables. Overall morbidity and mortality in entire cohort were 31.2% and 3.9%, respectively. Period B documented significant reduction in post‐operative mortality (5.4% vs 2.8%), post‐pancreatectomy haemorrhage (5.8% vs 3%) and bile leaks (3.4% vs 1.3%). However, incidence of delayed gastric emptying and clinically relevant post‐operative pancreatic fistula was higher in period B. With median follow‐up of 25 months, 3‐year overall survival and disease‐free survival for patients with pancreatic cancer were 43.7% and 38.7%, respectively, and that for periampullary tumours were 65.9% and 59.4%, respectively. Period B also corresponded with dissemination of technical expertise across diverse regions of India with specialised training of 35 surgeons.ConclusionOur study demonstrates the feasibility of delivering high‐quality care in a dedicated high‐volume centre even in a country with low incidence of pancreatic cancer with marked disparities in medical care and socio‐economic conditions. Improved outcomes underscore the need to promote regionalisation via a dedicated training programme.
The Pathophysiology, Presentation and Management of Ischaemic Colitis: A Systematic Review
Authors: Demetriou George , Nassar Ahmed , Subramonia Sriram 
Published: October 2019

AbstractThere are currently no guidelines on the long‐term management of patients after an episode of acute ischaemic colitis. Our aim was to review the literature on the pattern of presentation and the pathophysiology of this condition and to understand the current status of the acute and long‐term management of ischaemic colitis. Furthermore, we aim to provide recommendations for the clinicians in regard to the acute and long‐term management of ischaemic colitis. A review of the English literature over the last 15 years was performed using Embase and Medline. Search terms were ischaemic OR ischemic, colitis OR colon. Two reviewers screened the papers against pre‐determined eligibility criteria. A senior consultant surgeon performed a final overview. Three hundred sixty‐eight papers were identified on the initial search; 318 were irrelevant and 17 were conference abstracts; both were excluded. Thirty‐three full articles were assessed for suitability; nine were further excluded. Twenty‐four articles were included in the final analysis and cross‐referenced against those listed in the systematic reviews. There is a large clinical heterogeneity in inclusion criteria (histological, radiological, endoscopic, surgical specimen). Twelve out of 24 articles included patients only based on histological diagnosis. The definition of right and left (or nonright) ischaemic colitis was variable based on whether hepatic or splenic flexure was used as the cut‐off point. Five retrospective case series highlighted that patients with isolated right‐sided ischaemic colitis had a worse prognosis than those with left‐sided colitis (higher mortality, need for surgery, length of hospital stay). The overall recurrence was 9%. There is a need for a higher‐level evidence to guide clinicians on the long‐term management of patients following an episode of acute colonic ischaemia. Further evidence is required to determine whether right colonic ischaemia should be managed differently from left.
Characterization of infections and hypogammaglobulinemia treated with the combination of pertuzumab and trastuzumab
Authors: Mortimer Joanne E. , Kruper Laura , Jung Jae , Wong Louise , Cooper Jill , Stewart Daphne , Chung Samuel , Yu Kim Wai , Dadwal Sanjeet , Yuan Yuan 
Published: October 2019

Abstract

Purpose
We update a patient series that reported a high incidence of infection with Gram-positive cocci in women treated with the combination of pertuzumab and trastuzumab and further characterize this clinical problem.

Patients

Treating physicians and advanced practice partners identified women who developed infections while on treatment with pertuzumab and trastuzumab alone or in combination with chemotherapy and enrolled them onto this registry trial.

Results
Between March, 2014 and May, 2017, 48 patients with HER2-positive breast cancers were reported to have 59 individual infections. The median age was 48 years. Twenty-four patients received neoadjuvant therapy, 17 were treated for metastatic disease, and 7 were treated in the adjuvant setting. Pertuzumab and trastuzumab were combined with carboplatin and docetaxel in 24 (49%) patients, docetaxel in 10 (21%), nab-paclitaxel in 12 (24%), and without other agents in 2 (4%). Granulocyte growth factors were administered in 24 (49%) patients and no patients were documented to be neutropenic. Folliculitis developed in 25 (52%) patients and was counted as a single infection. Abscesses developed at a number of sites in 24 (49%) patients, including a septic knee requiring total knee replacement. Paronychia occurred in 7 (15%) patients, and 5 (10%) developed cellulitis. When cultures were obtained, Gram-positive cocci were consistently identified. Hypogammaglobulinemia was documented in 14 (36%) of the 33 patients tested.

Conclusions
Our data continue to support an increased risk of infections with Gram-positive cocci as a potentially serious adverse event in women treated with pertuzumab and trastuzumab.
Colonic duplication presenting as a huge abdominal mass in an adult female
Authors: Cheng Kung-Chuan , Ko Sheung-Fat , Lee Ko-Chao 
Published: October 2019

AbstractIntroductionDuplications of the alimentary tract are a rare congenital malformation. Most of the cases are symptomatic and diagnosed before 2 years of age. Here, we report a young female presented with a huge abdominal mass, and colonic duplication was confirmed during laparotomy.Case presentationA 29-year-old female had chronic constipation treated with laxative agents. She presented to the emergency room with abdominal cramping for 3 days, accompanied with intermittent fever and vomiting. A huge movable abdominal mass was noted during physical examination. Computerized tomography showed a long segmental dilated bowel lumen with stool impaction and bowel wall thickening of the dilated lumen in the left abdomen, highly suggestive of a long tubular colon duplication. The patient underwent subtotal colectomy. Specimen subsequently confirmed the diagnosis for colonic duplication from cecum to sigmoid colon, and the duplicated colon was found on the antimesenteric side of the native colon. She had a stable postoperative course and was discharged 9 days later.DiscussionDuplications of the alimentary tract are a rare congenital anomaly. Colonic duplication is an even more unusual malformation of this type. It can be classified into cystic or tubular type according to the gross morphology and may or may not be associated with other congenital anomalies. Most common presentation includes abdominal distention, refractory constipation, and bowel obstruction like many other colorectal conditions. Thus, its indistinct symptoms make it difficult to be diagnosed preoperatively. The recommended treatment is surgical resection of the duplicated lumen along with the attached native colon.
Contribution of plant food bioactives in promoting health effects of plant foods: why look at interindividual variability?
Authors: Morand Christine , Tomás-Barberán Francisco A. 
Published: October 2019

Abstract

Purpose
Research has identified plant-based diets as the most protective for our health; it is now essential to focus on good food associations and the beneficial constituents in plant foods. From a growing body of evidence, some categories of food phytochemicals are increasingly considered to play a crucial role in the cardiometabolic health effects associated with plant food consumption. However, the heterogeneity in responsiveness to plant food bioactive intake that is frequently observed in clinical trials can hinder the identification of the effects of these compounds in specific subpopulations and likely lead to underestimating their actual contribution to the health effects of their food sources.

Results
The magnitude and the main factors responsible for this between-subject variation in response to the consumption of the major families of food phytochemicals have been poorly documented so far. Thus, research efforts in this area must be developed. More importantly, capturing the interindividual variability in response to plant food bioactive intake, together with identifying the main determinants involved, is a crucial step that will enable the development and production of plant food products, thereby satisfying the nutritional needs and conferring benefits to different categories of populations.

Conclusion
The development of a science-based personalised nutrition approach focusing on plant foods rich in specific bioactive compounds could contribute to alleviating the dramatic burden of metabolic and cardiovascular diseases.
The network structure of schizotypy in the general population
Authors: Polner Bertalan , Faiola Eliana , Urquijo Maria F. , Meyhöfer Inga , Steffens Maria , Rónai Levente , Koutsouleris Nikolaos , Ettinger Ulrich 
Published: October 2019

AbstractSchizotypal personality traits show similarity with schizophrenia at various levels of analysis. It is generally agreed that schizotypal personality is multidimensional; however, it is still debated whether impulsive nonconformity should be incorporated into theories and measurement of schizotypy. In addition, relatively little is known about the network structure of the four-dimensional model of schizotypal personality. To estimate the network structure of schizotypy, we used data from participants recruited from the community (N = 11,807) who completed the short version of the Oxford-Liverpool Inventory of Feelings and Experiences, a widespread self-report instrument that assesses the positive, negative, disorganised and impulsive domains of schizotypy. We performed community detection, then examined differences between communities in terms of centralities and compared the strength of edges within and between communities. We found communities that almost perfectly corresponded to the a priori-defined subscales (93% overlap, normalised mutual information = 0.74). Items in the disorganisation community had higher closeness centrality relative to items in the other communities (Cliff’s Δs ranged from 0.55 to 0.83) and weights of edges within the disorganisation community were stronger as compared to the negative schizotypy and impulsive nonconformity communities (Cliff’s Δs = 0.33). Our findings imply that the inclusion of impulsive nonconformity items does not dilute the classical three-factor structure of positive, negative and disorganised schizotypy. The high closeness centrality of disorganisation concurs with theories positing that cognitive slippage and associative loosening are core features of the schizophrenic phenotype.
Duration gap analysis revisited method in order to improve risk management: the case of Chinese commercial bank interest rate risks after interest rate liberalization
Authors: Ausloos Marcel , Ma Qianhui , Kaur Parmjit , Syed Babar , Dhesi Gurjeet 
Published: October 2019

Abstract
Modern theories attach much attention to interest rate-related problems. We discuss the impacts of the interest rate liberalization, in China, for ten commercial banks of three markedly different ownership types. The methodology is based on revisited interest rate sensitivity analysis, duration analysis and value-at-risk analysis. The situation is examined within both vertical (composition of operating income and interest rate sensitivity gap for the ten banks in the same year) and horizontal (one bank over a 7-year period) aspects. Thereafter, we discuss the present management of interest rate risks by such banks. We conclude with several suggestions on how such commercial banks risk management can be refocused and on how their cases can be used for comforting other banking cases.
Identifying female pelvic cancer survivors with low levels of physical activity after radiotherapy: women with fecal and urinary leakage need additional support
Authors: Lindgren Anna , Dunberger G. , Steineck G. , Bergmark K. , Enblom A. 
Published: October 2019

Abstract

Objective
To investigate the frequency of physical activity among female pelvic cancer survivors (i.e., gynecological, rectal, and anal cancer survivors) and to investigate if survivors who practiced physical activity less than once a week differed from survivors practicing physical activity at least once a week with respect to urinary and fecal leakage, clinical and sociodemographic characteristics, quality of life (QoL), and depressed and anxious mood.

Methods
Female pelvic cancer survivors (n = 578, mean age 64 years) answered a questionnaire 6–48 months after radiotherapy. A multivariable regression model analyzed factors covarying with frequency of physical activity. We compared QoL and depressed and anxious mood between women practicing physical activity at least or less than once a week.

Results
Of 568 women delivering data, 186 (33%) practiced physical activity less than once a week while 382 (67%) practiced physical activity at least weekly. Women who leaked a large or all volume of stools (p = 0.01), had just elementary school level of education (p < 0.001), smokers (p = 0.049), or had lymphedema without receiving lymphedema treatment (p = 0.030) were more likely to practice physical activity less than weekly (50%, 45%, 45%, and 37%, respectively) compared with other women. Women practicing physical activity at least weekly reported better QoL (p < 0.001) and lower frequency of depressed mood (p = 0.044) compared with the others.

Conclusions
Female cancer survivors experiencing fecal leakage were less likely to practice weekly physical activity than survivors without leakage. The survivors practicing weekly physical activity experienced better QoL and experienced depressed mood less frequently than the others.
Post-Variscan thermal history of the Intra-Sudetic Basin (Sudetes, Bohemian Massif) based on apatite fission track analysis
Authors: Botor Dariusz , Anczkiewicz Aneta A. , Mazur Stanisław , Siwecki Tomasz 
Published: October 2019

AbstractThe Intra-Sudetic Basin, a ~ 12 km deep Variscan intramontane basin, has the best preserved post-orogenic sedimentary record available at the NE margin of the Bohemian Massif. Apatite fission track (AFT) analyses have been performed on 16 sedimentary and volcanic samples of Carboniferous to Cretaceous age from the Intra-Sudetic Basin to improve understanding of the post-Variscan thermal evolution. AFT central ages range from 50.1 ± 8.8 to 89.1 ± 7.1 Ma (Early Eocene to Coniacian), with 13 of them being Late Cretaceous. The mean track length values range from 12.5 ± 0.4 to 13.8 ± 0.5 (except for one sample 14.4 ± 0.2) µm. This relatively short mean track length together with the unimodal track length distributions and rather low standard deviation (0.8 to 1.7 µm) in most samples indicate a long stay in the partial annealing zone during slow cooling. However, in the northern part of the Intra-Sudetic Basin, samples show a wider track length distribution (standard deviation of 1.8 to 2.1 µm) that could indicate a more complex thermal evolution possibly related to Mesozoic reheating. Vitrinite reflectance data combined with thermal models based on the AFT results indicate that the Carboniferous strata reached maximum palaeotemperatures in the latest Carboniferous to Early Permian time, corresponding to a major coalification event. The second phase of temperature rise occurred due to Late Mesozoic sedimentary burial, but it had no influence on maturation of the Carboniferous organic matter. Final cooling phase in the Late Cretaceous–Paleogene was related to tectonic inversion of the Intra-Sudetic Basin, which occurred after deposition of a significant thickness of Cenomanian–Turonian sediments. Thermal modelling demonstrates that ~ 4 km thick cover of Upper Cretaceous sediments is required to obtain a good match between our AFT data and modelled time–temperature paths. This outcome supports a significant amount of Late Cretaceous–Paleogene inversion within the Variscan belt of Central Europe.
Efficacy of enteral nutrition in patients with Crohn’s disease on maintenance anti-TNF-alpha antibody therapy: a meta-analysis
Authors: Hirai Fumihito , Takeda Teruyuki , Takada Yasumichi , Kishi Masahiro , Beppu Tsuyoshi , Takatsu Noritaka , Miyaoka Masaki , Hisabe Takashi , Yao Kenshi , Ueki Tosiharu 
Published: October 2019

Abstract
Enteral nutrition (EN) is effective in Crohn’s disease (CD) patients and has been shown to have an inhibitory effect on loss of response to anti-tumor necrosis factor (TNF)-alpha antibody therapy; however, the current level of evidence is not sufficient. The objective of this meta-analysis was to determine whether EN in combination anti-TNF-alpha antibody therapy is useful in maintaining remission. PubMed was used to identify all relevant studies. A total of nine articles were identified including one randomized control trial, two prospective cohort studies, and six retrospective cohort studies. We performed a meta-analysis on all these articles to assess the remission maintenance effect of EN (n = 857). The remission or response maintenance effect in the EN group was 203/288 (70.5%), which was higher than 306/569 (53.8%) in the non-EN group. The odds ratio for long-term remission or response using fixed effects model and random effects model were 2.23 (95% CI 1.60–3.10) and 2.19 (95% CI 1.49–3.22), respectively. The usefulness of EN was unclear in two prospective studies that were conducted immediately after remission induction with anti-TNF-alpha antibody therapy was detected. Differences in the definition of relapse and the observation period among articles were considered to be limitations. This analysis suggests that EN is effective for maintaining remission in patients already in remission or response as a result of anti-TNF-alpha antibody maintenance therapy.
Measuring geometric accuracy in magnetic resonance imaging with 3D-printed phantom and nonrigid image registration
Authors: Nousiainen Katri , Mäkelä Teemu 
Published: October 2019

Abstract

Objective
We aimed to develop a vendor-neutral and interaction-free quality assurance protocol for measuring geometric accuracy of head and brain magnetic resonance (MR) images. We investigated the usability of nonrigid image registration in the analysis and looked for the optimal registration parameters.

Materials and methods
We constructed a 3D-printed phantom and imaged it with 12 MR scanners using clinical sequences. We registered a geometric-ground-truth computed tomography (CT) acquisition to the MR images using an open-source nonrigid-registration-toolbox with varying parameters. We applied the transforms to a set of control points in the CT image and compared their locations to the corresponding visually verified reference points in the MR images.

Results
With optimized registration parameters, the mean difference (and standard deviation) of control point locations when compared to the reference method was (0.17 ± 0.02) mm for the 12 studied scanners. The maximum displacements varied from 0.50 to 1.35 mm or 0.89 to 2.30 mm, with vendors’ distortion correction on or off, respectively.

Discussion
Using nonrigid CT–MR registration can provide a robust and relatively test-object-agnostic method for estimating the intra- and inter-scanner variations of the geometric distortions.
Institutional strategies related to test-taking behavior in low stakes assessment
Authors: Schüttpelz-Brauns Katrin , Hecht Martin , Hardt Katinka , Karay Yassin , Zupanic Michaela , Kämmer Juliane E. 
Published: October 2019

Abstract
Low stakes assessment without grading the performance of students in educational systems has received increasing attention in recent years. It is used in formative assessments to guide the learning process as well as in large-scales assessments to monitor educational programs. Yet, such assessments suffer from high variation in students’ test-taking effort. We aimed to identify institutional strategies related to serious test-taking behavior in low stakes assessment to provide medical schools with practical recommendations on how test-taking effort might be increased. First, we identified strategies that were already used by medical schools to increase the serious test-taking behavior on the low stakes Berlin Progress Test (BPT). Strategies which could be assigned to self-determination theory of Ryan and Deci were chosen for analysis. We conducted the study at nine medical schools in Germany and Austria with a total of 108,140 observations in an established low stakes assessment. A generalized linear-mixed effects model was used to assess the association between institutional strategies and the odds that students will take the BPT seriously. Overall, two institutional strategies were found to be positively related to more serious test-taking behavior: discussing low test performance with the mentor and consequences for not participating. Giving choice was negatively related to more serious test-taking behavior. At medical schools that presented the BPT as evaluation, this effect was larger in comparison to medical schools that presented the BPT as assessment.
Effective removal of the American bullfrog (Lithobates catesbeianus) on a landscape level: long term monitoring and removal efforts in Yosemite Valley, Yosemite National Park
Authors: Kamoroff Colleen , Daniele Ninette , Grasso Robert L. , Rising Rebecca , Espinoza Travis , Goldberg Caren S. 
Published: October 2019

Abstract
Invasive alien species are a major threat to freshwater ecosystems, and American bullfrogs are among the world’s 100 most prominent aquatic invasive species causing negative direct and indirect effect on native aquatic fauna worldwide. Bullfrogs were intentionally introduced into Yosemite Valley, Yosemite National Park in the 1950s where they became well established in the subsequent years. Starting in 2005, the National Park Service (NPS) began bullfrog removal, targeting various life stages using hand, net, and spear techniques. Starting in 2015, the NPS conducted environmental DNA (eDNA) surveys and deployed audio recordings devices to ensure adequate detection of bullfrogs. During the first year of cencerted effort in the Valley in 2005, the NPS removed 86% of all recorded bullfrog. The subsequent decade was spent searching for individuals with lower return on effort. In 2012, the NPS removed the last observed signs of bullfrog breeding, and the last observed bullfrog in 2019. Following removal of the breeding bullfrog population, the NPS began restoration projects for species of special concern. The NPS introduced the federally threatened California red-legged frogs (Rana draytonii) into Yosemite Valley beginning in 2016. This is the first published successful eradication of bullfrogs on a landscape level. National Parks and Monuments often provide refuges for imperiled wildlife and should be managed to remove invasive species. Our work highlights effective bullfrog removal is obtainable and can lead to local recovery of endangered species.