bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronicity is associated with the glenohumeral synovitis in patients with a rotator cuff tear
Authors: Kim Du‐Han , Bae Ki‐Cheor , Choi Jung‐Hoon , Na Sang‐Soo , Hwang Ilseon , Cho Chul‐Hyun 
Published: December 2020

AbstractSynovitis of the glenohumeral joint (GHJ) and subacromial space (SAS) is one of the most common findings during arthroscopic rotator cuff repair (RCR). The purpose of this study is to determine clinical factors associated with the degree of synovitis in patients with a rotator cuff tear and whether macroscopic synovitis affects early clinical outcomes following arthroscopic RCR. Arthroscopic videos of 230 patients treated with arthroscopic RCR were randomly reviewed by two experienced shoulder surgeons. The synovitis scores of the GHJ using Davis's grading system and the SAS using Jo's grading system were rated with a consensus. Univariate and multivariate analyses were used to identify the associations between the synovitis scores and various parameters, including demographics, preoperative, and postoperative clinical outcomes. Univariate analyses revealed that age, side, body mass index, duration of symptoms, preoperative stiffness, diabetes, muscle atrophy, fatty infiltration, tear size, preoperative clinical scores, and preoperative range of motion were significantly associated with the GHJ synovitis score (all p < 0.05). Multivariate analyses revealed that the duration of symptoms, tear size, and diabetes was significantly associated with the GHJ synovitis score (p = 0.048, p = 0.025, p = 0.011, respectively). Longer duration of symptoms, larger tear size, and the presence of diabetes was independently associated with increased GHJ synovitis in patients with a rotator cuff tear. These results suggest that GHJ synovitis might be more involved in the pathogenesis for pain and tear progression of rotator cuff disease compared with SAS synovitis.
Natural progression of periodontal diseases in Chinese villagers based on the 2018 classification
Authors: Iao Siniong , Pei Xiyan , Ouyang Xiangying , Liu Jianru , Liu Wenyi , Cao Caifang 
Published: December 2020

AbstractBackgroundBased on the 2018 classification, we aimed to determine the prevalence, distribution, and progression of periodontitis in the rural Chinese population without access to dental care.MethodsIn all, 404 subjects (28.7 ± 8.9 years, M:F = 182:222) were randomly enrolled in 1992 and re‐called in 1996. With the new classification, the prevalence and distribution of stage, grade, and extent were characterized. Stage progression was compared with the progression of clinical attachment loss (CAL) and radiographic bone loss (RBL).ResultsAt baseline, 94.1% villagers suffered from periodontitis, of whom 53.7% were in Stage III/IV. The prevalence of Stage III/IV increased from 18.2% in the age group of 15 to 24 years to 60.9% in 25 to 34‐year‐old group and 88.7% in the 35 to 44‐year‐old group. Significantly more Stage III/IV, generalized, and Grade C periodontitis were found in male villagers than female villagers. In 1996, the prevalence rate of periodontitis increased to 98.5%, with 80.0% in Stage III/IV. Further, 84.2% villagers presented with Grade C periodontitis based on longitudinal ΔCAL. The rate of progression (≥1 site with ΔCAL ≥3 mm) was 63.7%. Stage progression correlated significantly with CAL and RBL progression in Stage I/II, but this association was not found in Stage III/IV. Among subjects with disease progression in Stage III/IV, 90.4% shifted from localized to generalized cases. Furthermore, ceiling effects were observed in Stage III/IV.ConclusionsIn villagers without access to dental care, 94.1% suffered from periodontitis, with more than half having Stage III/IV disease based on the 2018 classification. The majority cases presented with rapid periodontal progression. Although stage progression correlated significantly with CAL and RBL progression in Stage I/II, ceiling effects existed in Stage III/IV.
The impact of a change in classification criteria on the prevalence of peri‐implantitis: A cross‐sectional analysis
Authors: Shimchuk Andy A. , Weinstein Bradley F. , Daubert Diane M. 
Published: December 2020

AbstractBackgroundPeri‐implantitis is a frequent finding but estimates of its prevalence vary widely. This may be due to the wide variety of disease definitions. In 2017 the World Workshop on Periodontal and Peri‐implant Diseases and Conditions established new criteria for disease definitions. The aim of this study is to assess the potential impact of a new definition on the future reporting of peri‐implant disease.MethodsData from a 2015 report of peri‐implant prevalence were examined using the new diagnostic criteria. This cross‐sectional study was performed on 95 patients with 220 implants who had their implants placed between 1998 and 2003. An examiner masked to the previous diagnosis examined the radiographs and patient data to make a diagnosis based on 3 mm of bone loss from the expected level of bone. This reanalysis was used to calculate the prevalence of peri‐implant disease and generate new relative risk indicators.ResultsThe mean follow‐up time for the patients was 10.9 years. Using the 2017 criteria, peri‐implant mucositis was found in 35.3% of the implants and 52.2% of the subjects, and peri‐implantitis occurred in 8.7% of the implants and 15.2% of the subjects. This constituted a drop in peri‐implantitis at both patient and implant level of nearly 50% from the prior analysis. Smoking at time of implant placement emerged as a new risk factor in this analysis that was not identified in the prior analysis.ConclusionsThe new diagnostic criteria significantly reduce the reported prevalence of peri‐implantitis and bring new risk factors into focus.
Simultaneous encapsulation of trans‐resveratrol and vitamin D3 in highly concentrated double emulsions
Authors: Díaz‐Ruiz Rocío , Valdeón Irene , Álvarez José Ramón , Matos María , Gutiérrez Gemma 
Published: December 2020

AbstractBACKGROUNDEncapsulation of biocompounds is essential to protect them from environmental factors that could enhance their oxidation or cause them to lose their beneficial properties due to extreme photosensitivity, among other factors. The main goal of this work was to study the feasibility of preparing concentrated double emulsions with a high loading capacity containing simultaneously trans‐resveratrol (RSV) and vitamin D3 (VitD3). Such emulsions could be used for food fortification or pharmaceutical formulations or as vehicles for targeted controlled release.RESULTSIn order to achieve large concentrations of the encapsulated compounds, all the double emulsions were formulated using a W1/O in W2 ratio of 80/20, while the ratios tested for W1 in O where 20/80 and 30/70. All the emulsions were characterized by droplet size, morphology, colloidal stability and encapsulation efficiency (EE) over a period of 6 weeks. VitD3 and RSV concentration were determined by a technique based on reverse‐phase high‐performance liquid chromatography. The viability of preparing concentrated W1/O/W2 emulsions containing both biocompounds has been demonstrated with satisfactory results. Initial RSV concentrations in the concentrated double emulsions formulated varied from 5.0 to 8.3 mg L−1, while for VitD3 values of 28–32 mg L−1 were obtained. The presence of VitD3 retarded RSV release in the formulated emulsions. It was observed that after 1 week of storage RSV EE increased around 10–50% when VitD3 was simultaneously encapsulated.CONCLUSIONSimultaneous encapsulation of RSV and VitD3 was possible in high internal phase emulsions. The emulsions presented high colloidal stability, being suitable for food fortification applications. © 2020 Society of Chemical Industry
Measurement of Marginal Placental Cord Insertion by Prenatal Ultrasound Was Found Not to Be Predictive of Adverse Perinatal Outcomes
Authors: Lutz Amanda Brosius , Young‐Lin Nichole , Leon‐Martinez Daisy , Bianco Isabel C. , Seckel Elizabeth , Mrazek‐Pugh Barbora , Bianco Katherine 
Published: December 2020

ObjectivesThe clinical importance of marginal cord insertion (MCI) is currently controversial. In this study, we examined the association between MCI and adverse perinatal outcomes. We also evaluated the ultrasound‐measured distance from the site of placental cord insertion (PCI) to the placental margin (PCI distance) and perinatal outcomes.MethodsThis was a retrospective cohort study of MCI and control pregnancies presenting to a single institution between September 2014 and August 2016. Marginal cord insertion was diagnosed on routine anatomy ultrasound scans at 20 weeks’ gestation. The primary outcome was fetal intolerance to labor. Secondary outcomes of interest included mode of delivery, gestational age at delivery, Apgar scores at 1 and 5 minutes, birth weight, delivery complications, and neonatal intensive care unit admission. The PCI distance was determined by an ultrasound review. Statistical significance was evaluated by a χ2 analysis, descriptive statistics, Wilcoxon tests, and regression models with log‐transformed outcomes, the PCI distance, or both as needed.ResultsOf 675 abnormal cord insertion cases, we identified 183 that met inclusion criteria. We found no statistically significant association between MCI and fetal intolerance to labor (odds ratio, 1.24 [95% confidence interval, 0.55–2.80]; P = .71) or secondary outcomes. Furthermore, we found no significant correlation between perinatal outcomes and the PCI distance.ConclusionsOur study suggests that MCI pregnancies, regardless of the specific PCI distance, might not be at increased risk of adverse perinatal outcomes. This finding questions the need for heightened antepartum surveillance of this patient population.
Arsenic biomineralization by iron oxidizing strain (Ochrobactrum sp.) isolated from a paddy soil in Hunan, China
Authors: Luo Xinghua , Jiang Xingxing , Xue Shengguo , Tang Xianjin , Zhou Chuhui , Wu Chuan , Qian Ziyan , Wu Kaikai 
Published: December 2020

AbstractThe biogeochemistry of iron (Fe) could affect arsenic (As) fate and change its availability. Fe(II) oxidation mediated by Fe oxidizing bacteria (FeOB) has the potential for As contamination remediation due to the formation of biogenic minerals. However, microbial Fe(II) oxidation coupled with the immobilization of As and the effect of FeOB on As remediation in soils has not been thoroughly investigated. In this study, a FeOB was isolated from a paddy soil and identified as Ochrobactrum sp. EEELCW01. The kinetics reactions were used to investigate how biological and chemical reactions were involved in the Fe(II)‐NO3−‐FeOB system. Microbial Fe(II) oxidation coupled As mineralization, as well as its application in As contaminated paddy soils was studied. The results suggested that biological pathway contributed to the Fe(II) oxidation and NO3− reduction in the whole process, in which the chemical Fe(II) oxidation by biogenic NO2− was involved. Meanwhile, Fe(II) facilitated the reduction of NO2− while inhibited the reduction of NO3−. Adding 2% or more bacteria led to a significant removal effect for aqueous As, resulting in the formation of lepidocrocite and two As‐containing minerals (angelellite, loellingite). With the simultaneous application of FeOB and NO3−, the available As content in soils decreased by 37.6% and stabilized at 0.80 mg kg−1 finally. In addition, the immobilization showed long‐term effect compared to the treatment with Fe(II) or NO3− alone. The study proved that the isolated FeOB had a significant ability for As mineralization and immobilization, which provided theoretical and application basis for the remediation of As contaminated soils.
Application of different geophysical techniques to study Technosol developed on metallurgical wastes
Authors: Magiera Tadeusz , Żogała Bogdan , Łukasik Adam , Pierwoła Jolanta 
Published: December 2020

AbstractResearch conducted in a municipal park in a small town located in the Province of Silesia (southern Poland) showed that the park vegetation was growing on a Technosol, formed on highly magnetic anthropogenic material. The metallurgical waste came from the local steel mill and foundry and creates a subsoil in a significant part of the municipal park. This waste is covered with an organic layer of approximately 10 cm. Utilizing specific magnetic and geoelectrical properties of the wastes, we proposed a unique combination of integrated geophysical measuring techniques including soil magnetometry, electrical resistivity tomography (ERT) with varying unit electrode spacing, and electromagnetic profiling (EM) to assess continuity, thickness, and the depth of the anthropogenic layer of metallurgical wastes. The maximal thickness of the metallurgical wastes was identified in the western part of the studied area, and the same material was found in the eastern part of the park forming individual lenses or nests within 8 m deep zone in the area of a buried ravine where the historical railway line was located. The shallow ERT profiles (with unit electrode spacing 0.5 m) also revealed a thin layer of material with high resistivity (>500 Ωm). Thermomagnetic analyses have shown that the sources of the extremely high magnetic susceptibility of the wastes were magnetite and metallic iron (αFe). The detected high concentration of Fe and Mn was not accompanied by potentially toxic metals and, at relatively high pH values (6.5–9.0), does not constitute a significant ecological threat.
Pterostilbene Alleviates Aβ1‐42‐Induced Cognitive Dysfunction via Inhibition of Oxidative Stress by Activating Nrf2 Signaling Pathway
Authors: Xu Jikai , Liu Jingyu , Li Qing , Mi Yan , Zhou Di , Meng Qingqi , Chen Gang , Li Ning , Hou Yue 
Published: December 2020

ScopeIn the present study, effect of pterostilbene on β‐amyloid 1‐42 (Aβ1‐42) induced cognitive impairment in mice is investigated and explored its possible mechanism of action.Methods and resultsThe behavior results show that pterostilbene alleviated Aβ1‐42‐induces cognitive dysfunction assessed using the Y‐maze test, novel object recognition task, Morris water maze test, and passive avoidance test. Pterostilbene alleviates neuron loss and accumulation of reactive oxygen species in Aβ1‐42 treated mouse brain. Additionally, pterostilbene promotes nuclear factor‐E2 p45‐related factor 2 (Nrf2) nuclear translocation and enhance the transcription and expression of antioxidant genes such as heme oxygenase‐1 and superoxide dismutase both in vivo and in vitro. Nrf2 inhibitor ML385 reverses the antioxidant function of pterostilbene in SH‐SY5Y cells. Nrf2 is the master regulator of oxidative homeostasis and can be activated by substrate adaptor sequestosome‐1 (also named p62). Pterostilbene promotes the binding of Kelch‐like ECH‐associated protein 1 and p62, which enhanced activation of Nrf2.ConclusionThe present study reports that pterostilbene alleviated Aβ1‐42‐induces cognitive dysfunction in mice. The mechanism of pterostilbene can be associated to the inhibition of oxidative stress through the Nrf2 signaling pathway.
The constrained forward shortest path tour problem: Mathematical modeling and GRASP approximate solutions
Authors: Carrabs Francesco , D'Ambrosio Ciriaco , Ferone Daniele , Festa Paola , Laureana Federica 
Published: December 2020

AbstractThis paper deals with the Constrained Forward Shortest Path Tour Problem, an NP‐complete variant of the Forward Shortest Path Tour Problem. Given a directed weighted graph G = (V, A), where the set of nodes V is partitioned into clusters T1, …, TN, the aim is determining a shortest path between two given nodes, s and d, with the properties that clusters must be visited according to a given order, and each arc can be crossed at most once. We introduce a mathematical formulation of the problem, and a reduction procedure to reduce the number of variables involved in the model. Furthermore, we propose a Greedy Randomized Adaptive Search Procedure (GRASP) algorithm to solve large instances of the problem. Computational tests show that the reduction procedure is very effective and its application significantly speeds up the resolution of the model. Moreover, the computational results certify the effectiveness of GRASP that often finds the optimal solution and, in general, provides quickly high‐quality sub‐optimal solutions.
Semi‐analytical treatment of spherical solids in smoothed‐particle hydrodynamics fluid simulations
Authors: Kostorz Wawrzyniec , Esmail‐Yakas Anton 
Published: December 2020

AbstractA method for modeling mobile spherical solids in Smoothed Particle Hydrodynamics simulations utilizing the semi‐analytical boundary formulation is given. The technique relies on evaluating individual contributions from ideally spherical bodies to the normalization factor and its gradient. A derivation is provided in both two and three dimensions (3D) and a close‐form solution is given for an arbitrary polynomial kernel function in 3D. The method is validated and implemented in an Smoothed‐Particle Hydrodynamics‐Discrete Element Method code to evaluate the solid fraction and results are compared to the previous standard.
Addendum to the paper “High‐order symmetric cubature rules for tetrahedra and pyramids”
Authors: Jaśkowiec Jan , Sukumar N. 
Published: December 2020

AbstractIn Jaśkowiec and Sukumar (Int J Numer Methods Eng, doi: 10.1002/nme.6528, 2020), we presented high‐order (p = 2–20) symmetric cubatures rules for tetrahedra and pyramids. This algorithm was sensitive to the initial location of the cubature nodes, and it did not converge for p > 11 over prisms and hexahedra (cubes). In this addendum, we resolve this issue and obtain high‐order symmetric rules over prisms and cubes. For the prism, we use the initial guess for the cubature rule as the tensor product of a cubature rule over a triangle and a univariate Gauss quadrature rule, and for the cube the initial guess is the tensor product of univariate Gauss quadrature rules. Verification and convergence tests are presented to affirm the accuracy of the cubature rules. On applying the cubature algorithm described in Jaśkowiec and Sukumar (Int J Numer Methods Eng, 121(11), 2418–2436, 2020), we also construct nonsymmetric high‐order (p = 2–20) cubature rules over prisms, cubes, and pyramids. In the supplementary materials, all cubature rules (128 digits of precision) are provided in a text file and in format.
Adjoint sensitivity analysis of steady laminar flows with respect to nongeometrical parameters
Authors: Dolci Daiane I. , de Sá Brasil Lima João , Privato Tomas S. , Carmo Bruno S. , Volpe Ernani V. 
Published: December 2020

AbstractThis work explores an alternative approach to computing sensitivity (derivatives) of functionals with respect to a broader range of control parameters in fluid flow problems. It builds upon the complementary character of the boundary problems that underlie the flow and the corresponding adjoint equations. Such complementarity is used to ensure well‐posedness of the latter, which then yields a solution that conveys information on a broad range of sensitivities. This formulation of the boundary problem can extend the range of applications of the adjoint method to a host of new possibilities. The methodology is applied to internal and external laminar steady flows and the results are compared to those obtained with a finite‐difference approach. Good agreement is observed in all cases, which demonstrates the correctness and applicability of the method.
Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots
Authors: Saderup Austin M. , Morrow Mary , Libby Anne M. , Coyle Ryan P. , Coleman Stacey S. , Zheng Jia‐Hua , Ellison Lucas , Bushman Lane R. , Kiser Jennifer J. , MaWhinney Samantha , Anderson Peter L. , Castillo‐Mancilla Jose R. 
Published: December 2020

Study ObjectiveTo assess the association between tenofovir diphosphate (TFV‐DP) in dried blood spots (DBS), a measure of cumulative tenofovir‐based antiretroviral (ART) adherence, with medication regimen complexity in persons with human immunodeficiency virus (PWH).DesignProspective clinical cohort (up to three visits over 48 weeks).SettingAcademic‐based HIV clinic.PatientsPWH receiving tenofovir disoproxil fumarate (TDF)‐based ART.MeasurementsDBS for TFV‐DP were collected at every study visit. Baseline patient‐level medication regimen complexity index (pMRCI) scores were calculated and categorized into three sub‐scores (disease‐specific [ART], non‐ART, and over‐the‐counter [OTC]). The pMRCI scores were evaluated to assess the association with TFV‐DP in DBS <350 fmol/punch after adjusting for clinical covariates. pMRCI scores were also categorized to estimate the adjusted relative risk (aRR) of having a TFV‐DP <350 fmol/punch between pMRCI quartiles.Main ResultsData from 525 participants (1,146 person‐visits) were analyzed. Baseline median (interquartile range [IQR]) pMRCI scores for participants with TFV‐DP in DBS <350 vs. ≥350 fmol/punch were 4 (3, 8) vs. 4 (2, 6) for ART, 27 (12, 31) vs. 12 (5, 22) for non‐ART, and 0 (0, 1) vs. 0 (0, 2) for OTC, respectively. For the non‐ART scores, the aRR for having a TFV‐DP in DBS <350 fmol/punch was 6.4 (95% CI: 2.0, 20.6; P=0.002) when comparing participants in the highest pMRCI quartile with those in the lowest quartile.ConclusionsHigher pMRCI for non‐ART medications is associated with lower adherence as measured by TFV‐DP in DBS. Future research should investigate whether reducing non‐ART medication complexity improves ART adherence and exposure in PWH.
Psychedelic‐assisted therapy for functional neurological disorders: A theoretical framework and review of prior reports
Authors: Stewart Benjamin , Dean Jon G. , Koek Adriana , Chua Jason , Wabl Rafael , Martin Kayla , Davoodian Naveed , Becker Christopher , Himedan Mai , Kim Amanda , Albin Roger , Chou Kelvin L. , Kotagal Vikas 
Published: December 2020

AbstractFunctional neurological disorders (FNDs), which are sometimes also referred to as psychogenic neurological disorders or conversion disorder, are common disabling neuropsychiatric disorders with limited treatment options. FNDs can present with sensory and/or motor symptoms, and, though they may mimic other neurological conditions, they are thought to occur via mechanisms other than those related to identifiable structural neuropathology and, in many cases, appear to be triggered and sustained by recognizable psychological factors. There is intriguing preliminary evidence to support the use of psychedelic‐assisted therapy in a growing number of psychiatric illnesses, including FNDs. We review the theoretical arguments for and against exploring psychedelic‐assisted therapy as a treatment for FNDs. We also provide an in‐depth discussion of prior published cases detailing the use of psychedelics for psychosomatic conditions, analyzing therapeutic outcomes from a contemporary neuroscientific vantage as informed by several recent neuroimaging studies on psychedelics and FNDs.
Potential herbal constituents for psoriasis treatment as protective and effective therapy
Authors: Dabholkar Neha , Rapalli Vamshi K. , Singhvi Gautam 
Published: December 2020

AbstractPsoriasis is a multifactorial and chronic skin disorder. It is a recurrent disease that requires incessant therapy. Psoriasis treatment includes topical and systemic routes using synthetic drugs that lead to severe unwanted adverse effects. Herbal therapy is widely used for thousands of years in countries like China and India. The use of herbal therapy in the developed region enhanced to a great extent and showed better efficacy towards psoriasis alone or as adjuvant to synthetic therapy. Herbal medicines have gained great attention in the treatment of psoriasis due to their lesser side effects compared to synthetic drugs. In this review, the various plant sources which have been found effective in psoriasis and can be used to develop novel therapeutics have been discussed. The mechanisms by which the phytoconstituents elicit anti‐psoriatic activity and various research studies that have proven the effectiveness of these natural products have also been compiled in this review.