bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dictionary selection for compressed sensing of EEG signals using sparse binary matrix and spatiotemporal sparse Bayesian learning
Authors: Dey Manika Rani , Shiraz Arsam , Sharif Saeed , Lota Jaswinder , Demosthenous Andreas 
Published: October 2020

Abstract
Online monitoring of electroencephalogram (EEG) signals is challenging due to the high volume of data and power requirements. Compressed sensing (CS) may be employed to address these issues. Compressed sensing using a sparse binary matrix, owing to its low power features, and reconstruction/decompression using spatiotemporal sparse Bayesian learning have been shown to constitute a robust framework for fast, energy efficient and accurate multichannel bio-signal monitoring. EEG signal, however, does not show a strong temporal correlation. Therefore, the use of sparsifying dictionaries has been proposed to exploit the sparsity in a transformed domain instead. Assuming sparsification adds values, a challenge, therefore, in employing this CS framework for the EEG signal, is to identify the suitable dictionary. Using real multichannel EEG data from 15 subjects, in this paper, we systematically evaluate the performance of the framework when using various wavelet bases while considering their key attributes namely number of vanishing moments and coherence with sensing matrix. We identified Beylkin as the wavelet dictionary leading to the best performance. Using the same dataset, we then compared the performance of Beylkin with the discrete cosine basis, often used in the literature, and the alternative of not using a sparsifying dictionary. We further demonstrate that using dictionaries (Beylkin and Discrete Cosine Transform (DCT)) may improve performance tangibly only for a high compression ratio (CR) of 80% and with smaller block sizes, as compared to using no dictionaries.
Role of defects and phonons in bandgap dynamics of monolayer WS2 at high carrier densities
Authors: Brasington Alexandra , Golla Dheeraj , Dave Arpit , Chen Bin , Tongay Sefaattin , Schaibley John , LeRoy Brian J , Sandhu Arvinder 
Published: October 2020

Abstract
We conduct ultrafast pump-probe spectroscopy in monolayer WS2 at high pump fluences to gain direct insight into interactions between a high density of carriers, defects, and phonons. We find that defects in the lattice play a major role in determining the relaxation dynamics by trapping the photoexcited carriers and acting as non-radiative recombination centers that emit phonons. In the high carrier density regime explored in our experiments, we observe substantial changes in the transient absorbance signal at unexpectedly long-time delays which we attribute to phonon-induced band gap modification. Our probe frequency dependent measurements and modeling indicate a renormalization of the bandgap by up to 23 meV. These results highlight the importance of defects and phonons for optical applications of monolayer transition metal dichalcogenides.
Clinical significance and immunogenomic landscape analyses of the immune cell signature based prognostic model for patients with breast cancer
Authors: Wang Shiyuan , Xiong Yuqiang , Zhang Qi , Su Dongqing , Yu Chunlu , Cao Yiyin , Pan Yi , Lu Qianzi , Zuo Yongchun , Yang Lei 
Published: October 2020

AbstractBreast cancer is one of the most common types of cancers and the leading cause of death from malignancy among women worldwide. Tumor-infiltrating lymphocytes are a source of important prognostic biomarkers for breast cancer patients. In this study, based on the tumor-infiltrating lymphocytes in the tumor immune microenvironment, a risk score prognostic model was developed in the training cohort for risk stratification and prognosis prediction in breast cancer patients. The prognostic value of this risk score prognostic model was also verified in the two testing cohorts and the TCGA pan cancer cohort. Nomograms were also established in the training and testing cohorts to validate the clinical use of this model. Relationships between the risk score, intrinsic molecular subtypes, immune checkpoints, tumor-infiltrating immune cell abundances and the response to chemotherapy and immunotherapy were also evaluated. Based on these results, we can conclude that this risk score model could serve as a robust prognostic biomarker, provide therapeutic benefits for the development of novel chemotherapy and immunotherapy, and may be helpful for clinical decision making in breast cancer patients.
Transmission of high-frequency vocalizations from hummingbirds living in diverse habitats
Authors: Duque F G , Rodriguez-Saltos C A , Monteros M F , Wilczynski W 
Published: October 2020

AbstractSome species of Andean hummingbirds produce high-frequency vocalizations which exceed the vocal range of most birds. They also challenge our understanding of the role of habitat structure in the evolution of vocal signals because these hummingbirds live in strikingly different habitats, ranging from cloud forest to high-altitude grasslands. Although these vocalizations are produced at high frequencies, they exhibit considerable variation in frequency content and temporal structure. The calls of the hummingbirds from the cloud forest are simpler and have a narrow frequency range compared to the complex song of the grasslands hummingbird. We hypothesized that each of the three high-frequency vocalizations is adapted for transmission in their habitat. We characterized the transmission of high-frequency vocal signals in the cloud forest and in the grasslands. All vocalizations attenuated and degraded substantially at short distances, suggesting that they are adapted for short-range communication. The simple vocalizations of the cloud-forest species transmitted better in both environments compared to the complex song of the grasslands hummingbird, probably due to relaxed constraints for high-frequency sounds in open habitats.
Phylogenetic patterns and ontogenetic origins of limb length variation in ecologically diverse lacertine lizards
Authors: Cordero Gerardo A , Maliuk Anastasiia , Schlindwein Xenia , Werneburg Ingmar , Yaryhin Oleksandr 
Published: October 2020

AbstractLimb length is intrinsically linked to function and, ultimately, fitness. Thus, it can co-evolve with habitat structure, as exemplified by tropical lizards in highly heterogeneous environments. But does lizard limb length respond in a similar manner during adaptive diversification in temperate zones? Here, we examine variation in habitat preference and limb length in lacertine lizards from the Palaearctic. We tested the following three hypotheses: (1) species of the Lacertini tribe descended from a generalist ancestor and subsequently underwent habitat specialization; (2) specialized ecological roles are associated with relative limb length in extant species; and (3) interspecific differences in limb length emerge in embryonic development. Our comparisons supported an ancestral ‘rocky’ or ‘generalist’ habitat preference, and phenotype–habitat associations were particularly supported when examining size-adjusted forelimb length in 69 species that represented all known Lacertini genera. Moreover, we revealed an elevated interlimb ratio in high-vegetation species, which might be linked to climbing performance in species with relatively longer forelimbs. Furthermore, embryonic limb variation was detected solely against an Eremiadini outgroup species. Instead, hind limb length differences within Lacertini originated in post-hatching ontogeny. The mechanisms that modulate limb growth are likely to be limited in Lacertini, because adaptive morphological change might mirror historical contingency and the ecological context wherein this clade diversified.
The influence of domestication, insularity and sociality on the tempo and mode of brain size evolution in mammals
Authors: Castiglione Silvia , Serio Carmela , Piccolo Martina , Mondanaro Alessandro , Melchionna Marina , Di Febbraro Mirko , Sansalone Gabriele , Wroe Stephen , Raia Pasquale 
Published: October 2020

AbstractThe ability to develop complex social bonds and an increased capacity for behavioural flexibility in novel environments have both been forwarded as selective forces favouring the evolution of a large brain in mammals. However, large brains are energetically expensive, and in circumstances in which selective pressures are relaxed, e.g. on islands, smaller brains are selected for. Similar reasoning has been offered to explain the reduction of brain size in domestic species relative to their wild relatives. Herein, we assess the effect of domestication, insularity and sociality on brain size evolution at the macroevolutionary scale. Our results are based on analyses of a 426-taxon tree, including both wild species and domestic breeds. We further develop the phylogenetic ridge regression comparative method (RRphylo) to work with discrete variables and compare the rates (tempo) and direction (mode) of brain size evolution among categories within each of three factors (sociality, insularity and domestication). The common assertion that domestication increases the rate of brain size evolution holds true. The same does not apply to insularity. We also find support for the suggested but previously untested hypothesis that species living in medium-sized groups exhibit faster rates of brain size evolution than either solitary or herding taxa.
Molecular phylogeny and biogeography ofPabstiella(Pleurothallidinae: Orchidaceae) highlight the importance of the Atlantic Rainforest for speciation in the genus
Authors: Gutiérrez Morales Nicolás , Toscano De Brito Antonio L V , Silvério Righetto Mauad Anna Victoria , De Camargo Smidt Eric 
Published: October 2020

AbstractPabstiella consists of c. 130 epiphytic species in the Neotropics. We present a phylogenetic analysis based on nrITS, matK and trnH-psbA sequences from 59 species of the genus and 40 Pleurothallidinae and two Laeliinae and one Bletiinae as an outgroup, using maximum likelihood, Bayesian inference and maximum parsimony. We also performed molecular dating, biogeographical analyses and ancestral morphological character reconstruction. Our results confirm the monophyly of Pabstiella with strong support. Ten clades are inferred and are herein proposed as sections. Pabstiella originated in the Andes and the Atlantic Rainforest in the Late Miocene (c. 7.93 Mya) in an epoch when these biomes were probably connected. A main vicariance event divided an early-diverging lineage that inhabited the Andes from an Atlantic Rainforest lineage that diversified in this region during the Pliocene and Pleistocene, mainly in the Serra do Mar in south-eastern Brazil. Our findings also suggest that the Atlantic Rainforest may have played an important role in the origin of subtribe Pleurothallidinae. The morphological character reconstruction showed high levels of homoplasy, with few recognized synapomorphies associated with stems and petals. Other characters related to the habit and stems were identified as important in the evolutionary history of the genus.
Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children
Authors: Ahtam Banu , Turesky Ted K , Zöllei Lilla , Standish Julianna , Grant P Ellen , Gaab Nadine , Im Kiho 
Published: October 2020

AbstractIntergenerational effects are described as the genetic, epigenetic, as well as pre- and postnatal environmental influence parents have on their offspring’s behavior, cognition, and brain. During fetal brain development, the primary cortical sulci emerge with a distinctive folding pattern that are under strong genetic influence and show little change of this pattern throughout postnatal brain development. We examined intergenerational transmission of cortical sulcal patterns by comparing primary sulcal patterns between children (N = 16, age 5.5 ± 0.81 years, 8 males) and their biological mothers (N = 15, age 39.72 ± 4.68 years) as well as between children and unrelated adult females. Our graph-based sulcal pattern comparison method detected stronger sulcal pattern similarity for child–mother pairs than child-unrelated pairs, where higher similarity between child–mother pairs was observed mostly for the right lobar regions. Our results also show that child–mother versus child-unrelated pairs differ for daughters and sons with a trend toward significance, particularly for the left hemisphere lobar regions. This is the first study to reveal significant intergenerational transmission of cortical sulcal patterns, and our results have important implications for the study of the heritability of complex behaviors, brain-based disorders, the identification of biomarkers, and targets for interventions.
European East–West divide in kidney disease: the need to understand the drivers of chronic kidney disease outcomes
Authors: Carriazo Sol , Ortiz Alberto 
Published: October 2020

Abstract
In this issue of ckj, Sever et al. (A roadmap for optimizing chronic kidney disease patient care and patient-oriented research in the Eastern European nephrology community. Clin Kidney J, this issue) present a roadmap for optimizing chronic kidney disease (CKD) patient care and patient-oriented research in Eastern Europe. The document clearly identifies current unmet needs and proposes corrective actions. Focusing on CKD epidemiology and outcomes, it collects evidence pointing to an East–West gradient for some key risk factors for CKD development. Thus, the prevalence of diabetes, raised blood pressure, obesity and tobacco use is higher in Eastern than in Western Europe. These risk factors may contribute to the higher CKD prevalence in Eastern Europe, which for the Eastern-most countries may be more than 2-fold higher than in Western Europe. The problem is compounded by the lower prevalence of dialysis and transplantation in Eastern Europe, especially in lower income countries. The combination of higher prevalence of CKD with lower prevalence of renal replacement therapy would be expected to result in higher CKD-associated mortality, but this is not the case. CKD-associated mortality may even be lower in the Eastern-most European countries than in Western Europe. The reasons for this discrepancy should be studied, since it may reveal serious additional healthcare issues, potentially related to high mortality from other non-communicable diseases (NCDs). If this is the case and the high mortality from other NCD is successfully addressed, pressure will further mount on renal replacement capacity needs in Eastern Europe.
Transcatheter aortic valve-in-valve post-dilatation as an overlooked risk factor of delayed coronary obstruction: a case report
Authors: Marchese Alfredo , Tarantini Giuseppe , Tito Antonio , Colombo Antonio 
Published: October 2020

Abstract

Background
The risk of coronary obstruction during transcatheter aortic valve-in-valve replacement (VIV-TAVR) in patients deemed at high risk for surgical re-intervention is still a concerning issue.

Case summary
A 78-year-old woman with a past medical history of hypertension, chronic kidney disease, and rheumatoid arthritis was referred for a symptomatic and severely stenotic surgical Mitroflow n.21 bio-prosthesis and was subsequently recommended for a VIV procedure. Multiple anatomical risk factors for coronary occlusion required a pre-emptive coronary chimney stenting protection. The implantation of an Evolut-R 23 mm valve resulted in a gradient of 21 mmHg thus, a post-dilatation with an 18 mm balloon was performed. Both electrocardiographic and haemodynamic parameters remained excellent, however, a hazardous leaflet dislodgment became evident. Regardless, a prophylactic chimney stenting was performed because of the operator’s perceived high risk of late coronary occlusion.

Discussion
The implantation of transcatheter valves inside failed surgically implanted aortic bio-prosthesis is broadly recognized as a safe and less-invasive alternative to repeated high-risk surgery. Although procedural success is achieved in the great majority of patients, this therapy may be jeopardized by rare but serious complications such as impending or established acute coronary occlusion. Several specific anatomical and procedural risk factors have been identified and primary coronary prevention strategies are often mandatory when they arise. Valve-in-valve post-dilation has been overlooked in its role as an additional risk factor of late coronary obstruction. Therefore, chimney stenting, performed after balloon post-dilation to prevent delayed coronary obstruction, even if the acute coronary event does not occur intra-procedurally, is strongly advisable.
Long-term clinical outcomes after major bleeding in patients with atrial fibrillation: the Fushimi AF registry
Authors: Ogawa Hisashi , An Yoshimori , Ishigami Kenjiro , Ikeda Syuhei , Doi Kosuke , Hamatani Yasuhiro , Fujino Akiko , Ishii Mitsuru , Iguchi Moritake , Masunaga Nobutoyo , Esato Masahiro , Tsuji Hikari , Wada Hiromichi , Hasegawa Koji , Abe Mitsuru , Lip Gregory Y H , Akao Masaharu ,   Fushimi AF Registry investigators
Published: October 2020

Abstract

Aims
Oral anticoagulants reduce the risk of ischaemic stroke but may increase the risk of major bleeding in atrial fibrillation (AF) patients. Little is known about the clinical outcomes of patients after a major bleeding event. This study assessed the outcomes of AF patients after major bleeding.

Methods and results
The Fushimi AF Registry is a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto, Japan. Analyses were performed on 4304 AF patients registered by 81 institutions participating in the Fushimi AF Registry. We investigated the demographics and outcomes of AF patients who experienced major bleeding during follow-up period. During the median follow-up of 1307 days, major bleeding occurred in 297 patients (6.9%). Patients with major bleeding were older than those without (75.6 vs. 73.4 years; P &lt; 0.01). They were more likely to have pre-existing heart failure (33.7% vs. 26.7%; P &lt; 0.01), history of major bleeding (7.7% vs. 4.0%; P &lt; 0.01), and higher mean HAS-BLED score (2.05 vs.1.73; P &lt; 0.01). On landmark analysis, ischaemic stroke or systemic embolism occurred in 17 patients (3.6/100 person-years) after major bleeding and 227 patients (1.7/100 person-years) without major bleeding, with an adjusted hazard ratio (HR) of 1.93 [95% confidence interval (CI), 1.06–3.23; P = 0.03]. All-cause mortality occurred in 97 patients with major bleeding (20.0/100 person-years) and 709 (5.1/100 person-years) patients without major bleeding [HR 2.73 (95% CI, 2.16–3.41; P &lt; 0.01)].

Conclusion
In this community-based cohort, major bleeding is associated with increased risk of subsequent all-cause mortality and thromboembolism in the long-term amongst AF patients.

Trial registration
https://www.umin.ac.jp/ctr/index.htm. Unique identifier: UMIN000005834. (last accessed 22 October 2020)
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3
Authors: Stoyanova Adelina , Galabov Angel S 
Published: October 2020

ABSTRACT
A novel approach for treatment of enterovirus infections was characterized. Application of treatment course of consecutive alternating administration (CAA) of triple combination of enterovirus replication inhibitors in experimental infections (20 MLD50) with coxsackievirus B3 (CVB3) strains in newborn mice is presented. It was established that in infection with cardiotropic Woodruff strain the combination of pleconaril, МDL-860 and oxoglaucine (PMO) subjected to the CAA scheme, a significant protective effect was observed. Monotherapeutic courses as well as simultaneously daily applied PMO were without effect. Analogous data were observed at experimental infection with the neurotriopic Nancy strain of CVB3. Following IC50 values of virus samples taken every day from target organs of infected animals during the whole period of study, a drug-resistance was established in monotherapy with compounds-partners in the PMO combination. At courses by the treatment scheme CAA of PMO development of drug-resistance was not established, but an increased susceptibility to the effect of the inhibitor-components in the combination was proven. Toxicity of PMO applied via the CAA scheme and in the monotherapeutic courses in both healthy and CVB3 infected animals was recorded. All data obtained prove the potential of the CAA treatment scheme for development of effective chemotherapy of enterovirus infections.
A map of tumor–host interactions in glioma at single-cell resolution
Authors: Caruso Francesca Pia , Garofano Luciano , D'Angelo Fulvio , Yu Kai , Tang Fuchou , Yuan Jinzhou , Zhang Jing , Cerulo Luigi , Pagnotta Stefano M , Bedognetti Davide , Sims Peter A , Suvà Mario , Su Xiao-Dong , Lasorella Anna , Iavarone Antonio , Ceccarelli Michele 
Published: October 2020

ABSTRACT

Background
Single-cell RNA sequencing is the reference technique for characterizing the heterogeneity of the tumor microenvironment. The composition of the various cell types making up the microenvironment can significantly affect the way in which the immune system activates cancer rejection mechanisms. Understanding the cross-talk signals between immune cells and cancer cells is of fundamental importance for the identification of immuno-oncology therapeutic targets.

Results
We present a novel method, single-cell Tumor–Host Interaction tool (scTHI), to identify significantly activated ligand–receptor interactions across clusters of cells from single-cell RNA sequencing data. We apply our approach to uncover the ligand–receptor interactions in glioma using 6 publicly available human glioma datasets encompassing 57,060 gene expression profiles from 71 patients. By leveraging this large-scale collection we show that unexpected cross-talk partners are highly conserved across different datasets in the majority of the tumor samples. This suggests that shared cross-talk mechanisms exist in glioma.

Conclusions
Our results provide a complete map of the active tumor–host interaction pairs in glioma that can be therapeutically exploited to reduce the immunosuppressive action of the microenvironment in brain tumor.
Complete phenomenon of reflection at the plane boundary of a dissipative anisotropic elastic medium
Authors: Sharma M D , Nain Suman 
Published: October 2020

SUMMARYA complex slowness vector governs the 3-D propagation of harmonic plane waves in a dissipative elastic medium with general anisotropy. In any sagittal plane, this dual vector is specified with phase direction, propagation velocity and coefficients for attenuation. A generalized reflection phenomenon is illustrated for incidence of inhomogeneous waves at the stress free boundary of the medium. Each reflected wave at the boundary is characterized by its propagation direction, propagation velocity, inhomogeneity, amplitude ratio, phase shift and energy flux. These propagation characteristics are exhibited graphically for a numerical example of anisotropic viscoelastic medium.