bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the implementation of rapid diagnostic tests in a malaria elimination setting
Authors: Liang Di , Jin Jia-Jie , Wang Wei-Ming , Cao Yuan-Yuan , Zhu Guo-Ding , Zhou Hua-Yun , Cao Jun , Huang Jia-Yan 
Published: July 2020

Abstract
Background
It was recommended that malaria rapid diagnostic tests (RDTs) should be available in all epidemiological situations. But evidence was limited on the implementation of RDTs and its effectiveness in malaria elimination settings. This study examined the implementation of RDTs and how it affected the diagnosis of imported malaria patients in Jiangsu Province, China.

Methods
To scale up RDTs, this study developed an intervention package with four major elements covering the supply of RDT test, the training on RDTs, the monitoring and management of RDT use, and the advocacy of RDTs. By using a pretest-posttest control group design, we implemented the interventions in 4 cities in Jiangsu Province with the rest nine cities as controlled areas, from January 2017 to January 2018. Difference-in-Difference approach was used to evaluate the impact of the scale-up of RDTs on the identification of malaria cases. Three binary outcome measures were included to indicate delayed malaria diagnosis, malaria cases with confirmed malaria diagnosis at township-level institutions, and severe malaria cases, respectively. Linear probability regression was performed with time and group fixed effects and the interaction term between time and group.

Results
Intervention areas received sufficient RDT test supply, regular professional training programs, monthly tracking and management of RDT supply and use, and health education to targeted population. The implementation of interventions was associated with 10.8% (P = 0.021) fewer patients with delayed diagnosis. But intervention areas did not see a higher likelihood of having confirmed diagnosis from township-level institutions (coefficient = -0.038, P = 0.185) or reduced severe malaria cases (coef. = 0.040, P = 0.592).

Conclusions
The comprehensive package of RDT implementation in this study is promising in scaling up RDT use and improving access to care among malaria patients, especially in malaria elimination settings.
DNA methylation biomarkers of future health outcomes in children
Authors: Shanthikumar Shivanthan , Neeland Melanie R. , Maksimovic Jovana , Ranganathan Sarath C. , Saffery Richard 
Published: July 2020

AbstractBiomarkers which predict future health outcomes are key to the goals of precision health. Such biomarkers do not have to be involved in the causal pathway of a disease, and their performance is best assessed using statistical tests of clinical performance and evaluation of net health impact. DNA methylation is the most commonly studied epigenetic process and represents a potential biomarker of future health outcomes. We review 25 studies in non-oncological paediatric conditions where DNA methylation biomarkers of future health outcomes are assessed. Whilst a number of positive findings have been described, the body of evidence is severely limited by issues with outcome measures, tissue-specific samples, accounting for sample cell type heterogeneity, lack of appropriate statistical testing, small effect sizes, limited validation, and no assessment of net health impact. Future studies should concentrate on careful study design to overcome these issues, and integration of DNA methylation data with other ‘omic’, clinical, and environmental data to generate the most clinically useful biomarkers of paediatric disease.
Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days
Authors: Ueda Takashi , Takesue Yoshio , Nakajima Kazuhiko , Ichiki Kaoru , Ishikawa Kaori , Takai Yoshiko , Yamada Kumiko , Tsuchida Toshie , Otani Naruhito , Takahashi Yoshiko , Ishihara Mika , Takubo Shingo , Ikeuchi Hiroki , Uchino Motoi , Kimura Takeshi 
Published: July 2020

Abstract
Background
A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained. Even though the recommended high Cmin of teicoplanin was associated with better clinical outcome, reaching the target concentration is challenging.

Methods
Pharmacokinetics and adverse events were evaluated in all eligible patients. For clinical efficacy, patients who had bacteremia/complicated MRSA infections were analyzed. The primary endpoint for clinical efficacy was an early clinical response at 72–96 h after the start of therapy. Five dosed of 12 mg/kg or 10 mg/kg was administered as an enhanced or conventional high loading dose regimen, respectively. The Cmin was obtained at 72 h after the first dose.

Results
Overall, 512 patients were eligible, and 76 patients were analyzed for treatment efficacy. The proportion of patients achieving the target Cmin range (20–40 μg/mL) by the enhanced regimen was significantly higher than for the conventional regimen (75.2% versus 41.0%, p < 0.001). In multivariate analysis, Cmin ≥ 20 μg/mL was an independent factor for an early clinical response (odds ratio 3.95, 95% confidence interval 1.25–12.53). There was no significant difference in the occurrence of adverse events between patients who did or did not achieve a Cmin ≥ 20 μg/mL.

Conclusion
A target Cmin ≥ 20 μg/mL might improve early clinical responses during the treatment of difficult MRSA infections using 12 mg/kg teicoplanin for five doses within the initial 3 days.
Studies of internal stress induced by solidification of menthol melt as temporary consolidant in archaeological excavations using resistance strain gauge method
Authors: Chen Xiuxiu , Xu Yang , Chen Ming , Huang Xiao , Luo Hongjie , Song Yicheng 
Published: July 2020

Abstract
Volatile organic solids, such as cyclododecane or menthol, have been employed as temporary reinforcement material during archaeological excavations. They are usually applied as melts and reinforcement is achieved once the melts solidify. Such solidification process can induce internal stress on the artifacts, which can be a big concern, especially to those very precious and fragile ones. However, information about such stress is still extremely limited at present. This paper proposes an experimental method based on resistance strain gauge technique to monitor the deformation induced by solidification of menthol melt. Bending tests are performed on very thin glass slides. The solidification process of menthol melt is well characterized by the development of mechanical strains. Then, menthol melts are applied to three kinds of simulated samples, i.e. glass, sandstone and rice paper, to investigate the mechanical response of preserved bodies upon solidification. It is found that menthol melt will generate certain amount expansion or contraction of the objects upon solidification. The stresses induced, evaluated according to obtained strains, are generally quite small, indicating that application of menthol as reinforcement material is safe in mechanics for cultural relics.
Growing a growth mindset: characterizing how and why undergraduate students’ mindsets change
Authors: Limeri Lisa B. , Carter Nathan T. , Choe Jun , Harper Hannah G. , Martin Hannah R. , Benton Annaleigh , Dolan Erin L. 
Published: July 2020

Abstract
Background
The extent to which students view their intelligence as improvable (i.e., their “mindset”) influences students’ thoughts, behaviors, and ultimately their academic success. Thus, understanding the development of students’ mindsets is of great interest to education scholars working to understand and promote student success. Recent evidence suggests that students’ mindsets continue to develop and change during their first year of college. We built on this work by characterizing how mindsets change and identifying the factors that may be influencing this change among upper-level STEM students. We surveyed 875 students in an organic chemistry course at four points throughout the semester and interviewed a subset of students about their mindsets and academic experiences.

Results
Latent growth modeling revealed that students tended to shift towards viewing intelligence as a stable trait (i.e., shifted towards a stronger fixed mindset and a weaker growth mindset). This trend was particularly strong for students who persistently struggled in the course. From qualitative analysis of students’ written survey responses and interview transcripts, we determined that students attribute their beliefs about intelligence to five factors: academic experiences, observing peers, deducing logically, taking societal cues, and formal learning.

Conclusions
Extensive prior research has focused on the influence of mindset on academic performance. Our results corroborate this relationship and further suggest that academic performance influences students’ mindsets. Thus, our results imply that mindset and academic performance constitute a positive feedback loop. Additionally, we identified factors that influence undergraduates’ mindset beliefs, which could be leveraged by researchers and practitioners to design more persuasive and effective mindset interventions to promote student success.
Assessing nest attentiveness of Common Terns via video cameras and temperature loggers
Authors: Sullivan Jeffery D. , Marbán Paul R. , Mullinax Jennifer M. , Brinker David F. , McGowan Peter C. , Callahan Carl R. , Prosser Diann J. 
Published: July 2020

Abstract
Background
While nest attentiveness plays a critical role in the reproductive success of avian species, nest attentiveness data with high temporal resolution is not available for many species. However, improvements in both video monitoring and temperature logging devices present an opportunity to increase our understanding of this aspect of avian behavior.

Methods
To investigate nest attentiveness behaviors and evaluate these technologies, we monitored 13 nests across two Common Tern (Sterna hirundo) breeding colonies with a paired video camera - temperature logger approach, while monitoring 63 additional nests with temperature loggers alone. Observations occurred from May to August of 2017 on Poplar (Chesapeake Bay, Maryland, USA) and Skimmer Islands (Isle of Wight Bay, Maryland, USA). We examined data respective to four times of day: Morning (civil dawn‒11:59), Peak (12:00‒16:00), Cooling (16:01‒civil dusk), and Night (civil dusk‒civil dawn).

Results
While successful nests had mostly short duration off-bouts and maintained consistent nest attentiveness throughout the day, failed nests had dramatic reductions in nest attentiveness during the Cooling and Night periods (p < 0.05) with one colony experiencing repeated nocturnal abandonment due to predation pressure from a Great Horned Owl (Bubo virginianus). Incubation appeared to ameliorate ambient temperatures during Night, as nests were significantly warmer during Night when birds were on versus off the nest (p < 0.05). Meanwhile, off-bouts during the Peak period occurred during higher ambient temperatures, perhaps due to adults leaving the nest during the hottest periods to perform belly soaking. Unfortunately, temperature logger data alone had limited ability to predict nest attentiveness status during shorter bouts, with results highly dependent on time of day and bout duration. While our methods did not affect hatching success (p > 0.05), video-monitored nests did have significantly lower clutch sizes (p < 0.05).

Conclusions
The paired use of iButtons and video cameras enabled a detailed description of the incubation behavior of COTE. However, while promising for future research, the logistical and potential biological complications involved in the use of these methods suggest that careful planning is needed before these devices are utilized to ensure data is collected in a safe and successful manner.
Surgical treatment of a giant right atrial myxoma
Authors: Numaguchi Ryosuke , Hashimoto Makoto , Koshima Ryuji , Mitsube Keijiro 
Published: July 2020

Abstract
Background
Right atrial myxoma is a rare anomaly. When present, it can rarely cause blood flow obstruction in the right cardiac chamber depending on its size and location. We herein report a rare case of a giant right atrial myxoma, which caused right heart failure due to tricuspid valve obstruction, along with our treatment experience.

Case presentation
A 59-year-old woman was admitted to our hospital for palpitations and edema of the lower extremity. Computed tomography image and transthoracic echocardiography showed a 57 mm × 63 mm giant tumor obstructing the tricuspid valve inflow. The tumor was excised surgically and the residual septal defect was repaired with a Dacron patch. Tricuspid valve annuloplasty was performed additionally. The postoperative course was uneventful and the patient was discharged on postoperative day 5.

Conclusion
Giant right atrial myxoma is a rare cause of tricuspid valve stenosis and right heart failure. Surgical resection is the most appropriate treatment option and should be performed as soon as possible after diagnosis.
Medical and surgical management of a pulmonary hypertensive adult patient with unrepaired complex congenital heart disease: a case report
Authors: Akagi Satoshi , Kasahara Shingo , Akagi Teiji , Nakamura Kazufumi , Ito Hiroshi 
Published: July 2020

Abstract
Background
Some patients with congenital heart defects are considered inoperable because of severe pulmonary arterial hypertension (PAH) at birth, and some of these patients are followed for a long period. Recently, PAH-specific drugs have been developed to treat PAH. These drugs might make it possible to operate in adult patients with congenital heart defects who were previously considered inoperable. However, it is unclear which cases are appropriate for treatment and how they should be managed.

Case presentation
We describe a 32-year-old woman who was diagnosed with a ventricular septal defect, patent ductus arteriosus, and coarctation of the aorta, as well as severe PAH at birth. The attending physician at the time decided not to perform total repair. We re-evaluated the patient’s haemodynamics at 32 years of age. Her mean pulmonary artery pressure was 105 mmHg, pulmonary vascular resistance was 14.5 Wood units and pulmonary blood flow-to-systemic blood flow ratio (Qp/Qs) was 2.8. However, she had good vasoreactivity to oxygen. Vasoreactivity testing with 100% oxygen showed decreases in the following measures: the mean pulmonary artery pressure was 88 mmHg, pulmonary vascular resistance was 3.8 Wood units, and Qp/Qs was 10.8. We repaired the cases of coarctation of the aorta, patent ductus arteriosus and ventricular septal defect without the occurrence of a pulmonary hypertension crisis after surgery by using PAH-specific drugs. Furthermore, the continuous use of PAH-specific drugs improved the patient’s symptoms and the 6-min walk distance and decreased the mean pulmonary artery pressure and pulmonary vascular resistance. Her mean pulmonary artery pressure was 22 mmHg, and her pulmonary vascular resistance was 4.7 Wood units at the one-year follow-up.

Conclusions
With perioperative use of PAH-specific drugs, CHDs can be repaired without the occurrence of a pulmonary hypertension crisis after surgery in patients with a good vasoreactivity response to oxygen, even if the PVR is high. Medical treatment and surgery can therefore treat PAH and improve patients’ exercise capacity over time.
Rhabdomyolysis-induced acute kidney injury requiring hemodialysis after a prolonged immobilization at home in 2 morbidly obese women: case reports with literature review
Authors: Sakai Kazuhiro , Omizo Hiroki , Togashi Ryo , Hayama Yuto , Ueno Masaki , Tomomitsu Yoshihiro , Nemoto Yoshikazu , Asakawa Shinichiro , Nagura Michito , Arai Shigeyuki , Yamazaki Osamu , Tamura Yoshifuru , Uchida Shunya , Shibata Shigeru , Fujigaki Yoshihide 
Published: July 2020

AbstractBackgroundRhabdomyolysis may develop into acute kidney injury (AKI), a life-threatening complication. Obese people are at risk for rhabdomyolysis due to prolonged immobilization. However, there are only a few reports of rhabdomyolysis-induced AKI due to prolonged immobilization after falls in morbidly obese people. Myoglobin is a causative compound for rhabdomyolysis-induced AKI, but the lack of treatments targeting its mechanism is a problem.Case presentationTwo morbidly obese women (body mass index > 40.0 kg/m2) who fell on the floor at home and remained in the same posture for more than 12 h developed rhabdomyolysis-induced AKI. Both patients received aggressive fluid resuscitation but required hemodialysis because of persistent oliguria. They underwent 11 and 2 intermittent hemodialysis (HD) sessions with a conventional polymethylmethacrylate (PMMA) high-flux dialyzer, respectively, and their renal functions returned to baseline after withdrawal of HD.ConclusionsWe should be aware that morbidly obese people are at risk for rhabdomyolysis-induced AKI due to prolonged immobilization, such as after falls. At present, prophylactic renal replacement therapy (RRT) is not recommended for rhabdomyolysis. We need to reevaluate whether RRT using the appropriate membranes to effectively remove myoglobin including the PMMA membrane can improve the renal outcome in patients with rhabdomyolysis-induced AKI.
Religiosity differences in the transition to first intercourse before age 18 among Polish students
Authors: Wróblewska Wiktoria 
Published: July 2020

AbstractPoland is a Catholic country and is one of a few countries in Europe where the percentage of people declaring themselves as non-believing remains rather low. Thus, most young Poles are brought up in Catholic families and receive religious instruction at school.The purpose of this study is to estimate the effects of religiosity and gender on the risk of first intercourse before age 18 among university students in Poland. We analysed data from two comparative studies of affective life, sexual behaviour, and attitudes conducted among university students in 2001 and 2013. We used survival analysis techniques to test for relative differences in the effects of religiosity on the timing of first sexual intercourse. While the results confirm that religiosity was a significant differentiating factor in the sexual behaviours of students in Poland, they also show that religiosity was a significant predictor of sexual abstinence only if a young person regarded religion as very important. The unadjusted median age at first sex for the participants who attached no or little importance to religion was more than 2 years lower than the median age among those who considered religion very important and attended church services regularly. The findings also indicate that there were significant gender differences, with young males transitioning to sex earlier than young females, albeit only among the 2001 cohort. The multivariate analyses confirm the absence of significant gender differences in FSI before age 18 within religious groups (controlling for other factors) in the cohort of students born after 1990. The results for control variables are consistent with the literature indicating that growing up in a two-parent household has a protective effect, and that teenage lifestyles are significant. Our observation of a distinct polarity of students with respect to religiosity and the timing of sexual debut may be a starting point for further analyses of FSI determinants.
Relationship between Religion and Unintended Childbearing in Nigeria: A Cross-Regional Perspective
Authors: Oyediran Kola’ A. , Ishola Gbenga , Bankole Akinrinola 
Published: July 2020

Abstract
Context
Childbearing remains a global public health issue, posing an enormous challenge to families, communities, governments, program managers, and researchers, especially in developing countries.

Objective
The study examines the influence of religion on women’s experience of unintended childbearing in Nigeria.

Method
Using the 2018 Demographic and Health Survey, the analysis focused on 13,109 women of reproductive age who had a birth within 2 years preceding the date of the interview. Multivariate logistic regression was used to examine the association between religion and unintended childbearing.

Results
Nearly 13% of births in Nigeria over the last 2 years were unintended. The results showed that Muslims are less likely to experience unintended childbearing compared to Christians (Catholics as well as other Christians). In addition to religion having independent effects on unintended childbearing, the association between religion and unintended childbearing also depends on the region of residence. Muslims in the northern regions are less likely to have unintended births relative to Muslims in the southern regions.

Conclusion
Policy and program interventions to address unintended childbearing should take into consideration the country’s religious diversity as well as regional sociocultural influences on reproductive preferences and behavior.
A prospective study to validate the functional assessment of cancer therapy (FACT) for epidermal growth factor receptor inhibitor (EGFRI)-induced dermatologic toxicities FACT-EGFRI 18 questionnaire: SWOG S1013
Authors: Wong Siu-Fun , Unger Joseph M. , Wade James L. , Wagner Lynne I. , Lacouture Mario E. , Humphries Keisha C. , Moseley Anna , Arnold Kathryn , Velasco Mario R. , Floyd Justin D. , Esparaz Benjamin T. , Barzi Afsaneh , Lenz Heinz-Josef , Koczywas Marianna , Dakhil Shaker , Burton Gary V. , Fisch Michael J. , Henry N. Lynn , Hershman Dawn L. , Moinpour Carol M. 
Published: July 2020

Abstract
Background
Papulopustular rash is a common class effect of epidermal growth factor receptor inhibitors (EGFRI) that can affect patients’ health-related quality of life and cause disruptions to treatment. SWOG S1013 (NCT01416688) is a multi-center study designed to validate the Functional Assessment of Cancer Therapy EGFRI 18 (FACT-EGFRI 18) using 7-items from the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 to assess EGFRI-induced skin-related toxicities and their impact on functional status.

Methods
Patients with a diagnosis of colorectal or lung cancer to receive EGFRI therapies for at least 6 weeks were enrolled. Patient self-assessments using the FACT-EGFRI 18 were completed prior to undergoing CTCAE assessment by trained clinicians at baseline, weekly × 6, and then monthly × 3. The psychometric properties of the FACT-EGFRI 14 (skin toxicity items only) and 18 (plus 2 nail and 2 hair items) were established based on criterion validity, known groups validity, internal consistency reliability, and responsiveness to change.

Results
Of the 146 registered patients, 124 were evaluable. High Cronbach’s alpha (> 0.70) for both FACT-EGFRI 14 and FACT-EGFRI 18 scores across assessment times were observed. Although agreement (i.e. criterion validity) between individual and summary scales of the FACT-EGFRI 18 for assessing skin toxicity was good, agreement with the clinician-reported CTCAE was only fair. The minimal important difference was determined to be 3 points. The results also demonstrated responsiveness to symptom change.

Discussion
Based on the results of this multi-center validation study, the FACT-EGFRI 18 patient-reported outcome instrument provided data from the patient’s perspective yielding unique information as well as complementing clinician-rated CTCAE grades, especially for the symptoms of pain, pruritus, and paronychia.

Conclusions
Good to excellent psychometric properties for the FACT-EGFRI 18 were demonstrated, supporting further use of this patient-reported outcomes measure. Additional validation with a more diverse group of patients should be conducted.