bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Differences Between Practical and Cognitive Presumptions
Authors: Bodlović Petar 
Published: August 2020

AbstractThe study of presumptions has intensified in argumentation theory over the last years. Although scholars put forward different accounts, they mostly agree that presumptions can be studied in deliberative and epistemic contexts, have distinct contextual functions (guiding decisions vs. acquiring information), and promote different kinds of goals (non-epistemic vs. epistemic). Accordingly, there are “practical” and “cognitive” presumptions. In this paper, I show that the differences between practical and cognitive presumptions go far beyond contextual considerations. The central aim is to explore Nicholas Rescher’s contention that both types of presumptions have a closely analogous pragmatic function, i.e., that practical and cognitive presumptions are made to avoid greater harm in circumstances of epistemic uncertainty. By comparing schemes of practical and cognitive reasoning, I show that Rescher’s contention requires qualifications. Moreover, not only do practical and cognitive presumptions have distinct pragmatic functions, but they also perform different dialogical functions (enabling progress vs. preventing regress) and, in some circumstances, cannot be defeated by the same kinds of evidence. Hence, I conclude that the two classes of presumptions merit distinct treatment in argumentation theory.
Spatial Disaggregation of Social Indicators: An Info-Metrics Approach
Authors: Fernandez-Vazquez Esteban , Diaz Dapena Alberto , Rubiera-Morollon Fernando , Viñuela Ana 
Published: August 2020

AbstractIn this paper we propose a methodology to obtain social indicators at a detailed spatial scale by combining the information contained in census and sample surveys. Similarly to previous proposals, the method proposed here estimates a model at the sample level to later project it to the census scale. The main novelties of the technique presented are that (i) the small-scale mapping produced is perfectly consistent with the aggregates -regional or national- observed in the sample, and (ii) it does not require imposing strong distributional assumptions. The methodology suggested here follows the basics presented on Golan (2018) by adapting a cross-moment constrained Generalized Maximum Entropy (GME) estimator to the spatial disaggregation problem. This procedure is compared with the equivalent methodology of Tarozzi and Deaton (2009) by means of numerical experiments, providing a comparatively better performance. Additionally, the practical implementation of the methodology proposed is illustrated by estimating poverty rates for small areas for the region of Andalusia (Spain).
Enabling Dynamic System Integration on Maxeler HLS Platforms
Authors: Kritikakis Charalampos , Koch Dirk 
Published: August 2020

AbstractHigh Level Synthesis (HLS) tools enable application domain experts to implement applications and algorithms on FPGAs. The majority of present FPGA applications is following a stream processing model which is almost entirely implemented statically and not exploiting the benefits enabled by partial reconfiguration. In this paper, we propose a generic approach for implementing and using partial reconfiguration through an HLS design flow for Maxeler platforms. Our flow extracts HLS generated HDL code from the Maxeler compilation process in order to implement a static FPGA infrastructure as well as run-time reconfigurable stream processing modules. As a distinct feature, our infrastructure can accommodate multiple partial modules in a pipeline daisy-chained manner, which aligns directly to Maxeler’s dataflow programming paradigm. The benefits of the proposed flow are demonstrated by a case study of a dynamically reconfigurable video processing pipeline delivering 6.4GB/s throughput.
An unusual case of melanoma metastasis in the buccal space: learning by mistakes to distinguish it from salivary neoplasms
Authors: Grillo P. , Savoldi A. P. , Di Meo R. , Granata G. , Rodà G. M. , Arrigoni G. , Saibene A. M. , Franceschelli G. , Patella F. , Cariati M. 
Published: August 2020

Abstract
Background
The buccal space is an unusual location of malignancies. We report here the case of a woman with a melanoma metastasis in buccal fat pad, to evaluate the imaging features which might lead to the correct, although uncommon, diagnosis.

Case presentation
A 71-year-old woman presented with a painless visible swelling of the left cheek. MRI revealed the presence of a solid lesion located in the buccal fat pad with features suggestive of malignancy. It showed T1 hyperintensity and T2 hypointensity, and restriction of diffusion. Histological examination showed neoplastic cells compatible with melanoma.

Discussion
The lesion features (T1 hyperintensity and T2 hypointensity) initially lead our team to believe that there was a hemorrhagic component, possibly a residue of the biopsy. However, when associated with other malignancy features, such as low apparent diffusion coefficient (ADC) values and contrast enhancement, they should evoke the suspect of melanoma, provided that no biopsy was performed and no trauma occurred in the 3–7 days before.
The Long Non-coding Road to Atherosclerosis
Authors: Josefs Tatjana , Boon Reinier A. 
Published: August 2020

Abstract
Purpose of Review
To summarize recent insights into long non-coding RNAs (lncRNAs) involved in atherosclerosis. Because atherosclerosis is the main underlying pathology of cardiovascular diseases (CVD), the world’s deadliest disease, finding novel therapeutic strategies is of high interest.

Recent Findings
LncRNAs can bind to proteins, DNA, and RNA regulating disease initiation and plaque growth as well as plaque stability in different cell types such as endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and macrophages. A number of lncRNAs have been implicated in cholesterol homeostasis and foam cell formation such as LASER, LeXis, and CHROME. Among others, MANTIS, lncRNA-CCL2, and MALAT1 were shown to be involved in vascular inflammation. Further regulations include, but are not limited to, DNA damage response in ECs, phenotypic switch of VSMCs, and various cell death mechanisms. Interestingly, some lncRNAs are closely correlated with response to statin treatment, such as NEXN-AS1 or LASER. Additionally, some lncRNAs may serve as CVD biomarkers.

Summary
LncRNAs are a potential novel therapeutic target to treat CVD, but research of lncRNA in atherosclerosis is still in its infancy. With increasing knowledge of the complex and diverse regulations of lncRNAs in the heterogeneous environment of atherosclerotic plaques, lncRNAs hold promise for their clinical translation in the near future.
Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation
Authors: Ćorović Andrej , Wall Christopher , Mason Justin C. , Rudd James H. F. , Tarkin Jason M. 
Published: August 2020

Abstract
Purpose of Review
To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field.

Recent Findings
While PET imaging with 18F-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies.

Summary
Future research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases.
Post-salt trapping mechanism of south-east Pre-Caspian and its application to petroleum exploration
Authors: Akhmetzhanov Aitbek , Zholtayev Geroy , Djeddou Abdelkader , Akhmetzhanova Gauhar , Oraz Bauyrzhan 
Published: August 2020

AbstractThe Kungurian saliferous sediments of the Pre-Caspian sedimentary basin represented by thick stratum of rock salt with interlayered lenses of anhydrites, terrigenous and carbonate rocks. Initial thickness of these sediments estimated as 4000–4500 m at the center of the depression and 1000–2000 m on the edges of the basin. The processes of halokinesis led to formation of more than 1200 salt dome structures represented by salt diapirs and walls, ridges and salt pillows. Number of salt dome related structures of Mesozoic clastic deposits revealed by seismic exploration carried out in 70–90′s of last century are quite common on the south-eastern part of the Pre-Caspian Sedimentary basin. Most of hydrocarbon pools in post-salt clastic rocks have been discovered on fault-related anticline prospects which are derived from salt tectonics morphologically variable (Munyithya et al. Petrol Explor Prod Technol 10: 2257–2267. https://doi.org/10.1007/s13202-020-00917-1, 2020). Other potential traps anticipated in the area are stratigraphic traps, pinch-out and unconformity-related traps, trapped by salt domes and walls or by salt overhang, etc.
Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
Authors: Tang Jie-lin , Yang Qi , Xu Chong-hui , Zhao He , Liu Ya-ling , Liu Can-yu , Zhou Yuan , Gai Dong-wei , Pei Rong-juan , Wang Yun , Hu Xue , Zhong Bo , Wang Yan-yi , Chen Xin-wen , Chen Ji-zheng 
Published: August 2020

AbstractTANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered. We show here that during the early stage of viral infection, the acetylation of TBK1 was increased, and the acetylation of TBK1 at Lys241 enhanced the recruitment of IRF3 to TBK1. HDAC3 directly deacetylated TBK1 at Lys241 and Lys692, which resulted in the activation of TBK1. Deacetylation at Lys241 and Lys692 was critical for the kinase activity and dimerization of TBK1 respectively. Using knockout cell lines and transgenic mice, we confirmed that a HDAC3 null mutant exhibited enhanced susceptibility to viral challenge via impaired production of type I IFNs. Furthermore, activated TBK1 phosphorylated HDAC3, which promoted the deacetylation activity of HDAC3 and formed a feedback loop. In this study, we illustrated the roles the acetylated and deacetylated forms of TBK1 play in antiviral innate responses and clarified the post-translational modulations involved in the interaction between TBK1 and HDAC3.
Determining the potential retention of a forest catchment based on the CN parameter
Authors: Wróbel Michał , Boczoń Andrzej 
Published: August 2020

AbstractForests play one of the most important roles in the hydrological cycle; as a result, knowledge about the water relations in forest areas should be of great importance in the context of global change. In Poland, the level of groundwater in forest areas has been decreasing for several decades, which negatively affects forest stands. To prevent this, activities have been carried out to increase water resources. Therefore, there is a need to develop a method for prioritizing the locations of retention investment projects. While searching for simple methods to achieve this goal, it was assumed that retention facilities should be located first in the partial catchments with the greatest possible retention capacities. This value, which is called the potential retention of the catchment, can be calculated using the CN parameter, which is used in the soil conservation service–curve number (SCS–CN) method. The CN parameter contains information on the type of land cover, the type of soil, and the moisture content. The source of the obtained land-use data was the Corine Land Cover (CLC) database, which was developed by the European Environment Agency for the area of the European Union. The analyses were carried out on the forest catchment of the Łutownia River, which is located in the Białowieża Primeval Forest.
Co-purchaser Recommendation for Online Group Buying
Authors: Chen Jihong , Chen Wei , Huang Jinjing , Fang Jinhua , Li Zhixu , Liu An , Zhao Lei 
Published: August 2020

AbstractOnline group buying is a burgeoning business model of Internet shopping, in which people with the same merchandise interests form a group and co-purchase goods with favorable prices. The buyer who launches the co-purchase is called the initiator, and other buyers are called the co-purchasers. Although recommending co-purchasers for a target buyer (co-purchase initiator) on the group buying is an interesting problem, existing studies have paid few attention to this topic. Different from the collaborator recommendation that only considers users with high similarity to the target user, co-purchaser recommendation takes both users with high and weak similarity into account, and the recommendation results can achieve high recall and diversity. However, the task turns out to be a challenging problem since it is hard to make a precise recommendation for buyers with weak similarity. To address the problem, we propose the following two methods. In the first one, we directly impose a penalty to the weak similar co-purchasers in the embedding space. To further improve the recommendation performance, in the second one, we smoothly increase the co-occurrence probability of the weak similar co-purchasers by truncated bias walk. Our experimental results on real datasets show that the proposed methods, particularly the latter, can effectively complete the co-purchaser recommendation and has high recommendation performance. In addition, considering that co-purchase may last longer, the total recommendation result can be generated in multiple stages and adjust the current recommendation list based on the feedback from the recommendation of previous stages. It is a trick for all co-purchaser recommendation methods to make the total result better.
End-of-Life Issues in Intensive Care Units
Authors: Metaxa Victoria 
Published: August 2020

AbstractCritical care clinicians strive to reverse the disease process and are frequently faced with difficult end-of-life (EoL) situations, which include transitions from curative to palliative care, avoidance of disproportionate care, withholding or withdrawing therapy, responding to advance treatment directives, as well as requests for assistance in dying. This article presents a summary of the most common issues encountered by intensivists caring for patients around the end of their life. Topics explored are the practices around limitations of life-sustaining treatment, with specific mention to the thorny subject of assisted dying and euthanasia, as well as the difficulties encountered regarding the adoption of advance care directives in clinical practice and the importance of integrating palliative care in the everyday practice of critical-care physicians. The aim of this article is to enhance understanding around the complexity of EoL decisions, highlight the intricate cultural, religious, and social dimensions around death and dying, and identify areas of potential improvement for individual practice.
Elderly Patients in the Intensive Care Unit
Authors: Flaatten Hans , Beil Michael , Guidet Bertrand 
Published: August 2020

AbstractVery old intensive care unit (ICU) patients, aged ≥ 80 years, are by no mean newcomers, but during the last decades their impact on ICU admissions has grown in parallel with the increase in the number of elderly persons in the community. Hence, from being a “rarity,” they have now become common and constitute one of the largest subgroups within intensive care, and may easily be the largest group in 20 years and make up 30 to 40% of all ICU admissions. Obviously, they are not admitted because they are old but because they are with various diseases and problems like any other ICU patient. However, their age and the presence of common geriatric syndromes such as frailty, cognitive decline, reduced activity of daily life, and several comorbid conditions makes this group particularly challenging, with a high mortality rate. In this review, we will highlight aspects of current and future epidemiology and current knowledge on outcomes, and describe the effects of the aforementioned geriatric syndromes. The major challenge for the coming decades will be the question of whom to treat and the quest for better triage criteria not based on age alone. Challenges with the level of care during the ICU stay will also be discussed. A stronger relationship with geriatricians should be promoted to create a better and more holistic care and aftercare for survivors.
Clinical Utilization and Cost of Thrombophilia Testing in Patients with Venous Thromboembolism
Authors: Gaddh Manila , Cheng En , Elsebaie Maha A.T. , Bodó Imre 
Published: August 2020

Abstract
Introduction Testing for inherited and acquired thrombophilias adds to the cost of care of patients with venous thromboembolism (VTE), though results may not influence patient management.
Methods This is a single-center, retrospective study conducted at Emory University Hospitals from January to December 2015 to (1) determine the pattern of thrombophilia testing in patients with VTE, (2) study the impact of results of thrombophilia testing on clinical decision-making, and (3) determine the direct costs of thrombophilia testing in patients with VTE.
Results Of the 266 eligible patients, 189 (71%) underwent testing; 51 (26.9%) tested positive and the results impacted management in 32 (16.9%) of tested patients. Patient undergoing testing were more likely to be younger than 40 years (30.9 vs. 18.2%), have had prior pregnancy loss (9.0 vs. 0%), or known family history of hypercoagulability (24.9 vs. 10.4%), and were less likely to have had provoked VTE (37 vs. 79.2%). The most common thrombophilias tested were antiphospholipid syndrome (60.1%), factor V Leiden (59.7%), and prothrombin gene mutation (57.5%). Direct costs of thrombophilia testing were $2,364.32 per patient, $12,331.55 to diagnose 1 positive, and $19,653.41 per patient-management affected.
Conclusion We noted significant variability in selection of patients and panel of tests, sparse utilization of test results in patient management, but high cost associated with thrombophilia testing in patients with VTE. With guidelines advocating selective use of thrombophilia testing and attention to potential impact of test results in patient management, we propose the need for measures at institutional levels to improve test-ordering practices.
Evidence on the Link between Respiratory Syncytial Virus Infection in Early Life and Chronic Obstructive Lung Diseases
Authors: Baraldi Eugenio , Bonadies Luca , Manzoni Paolo 
Published: August 2020

There is growing evidence in medical literature to support an association between early-life respiratory syncytial virus lower respiratory tract-lower respiratory tract infection (RSV-LRTI) and recurrent wheezing/asthma-like symptoms. It has been estimated that children with a history of RSV-LRTI have a 2- to 12-fold higher risk of developing asthma. The connection between RSV infection and a developmental trajectory of reduced lung function remains throughout adolescence and early adulthood, suggesting a possible role for RSV even in the inception of chronic obstructive pulmonary disease. That is why the postnatal period appears to offer a specific window of opportunity for early intervention to prevent chronic obstructive lung diseases. The mechanisms by which RSV contributes to the onset of wheezing/asthma and lung function impairment are not fully understood but appear to relate to injury caused directly by the virus and/or to pre-existing predisposing factors. While awaiting a deeper understanding of the association between RSV and chronic lung diseases, the crucial role of pediatricians and physicians is to develop strategies to prevent RSV infections to try and protect children's lifelong respiratory health.Key Points
Outcomes of Isolated Fetal Ventriculomegaly That Resolve In Utero
Authors: Ma'ayeh Marwan , Ward Calvin L. , Chitwood Abigail , Gee Stephen E. , Schneider Patrick , Rood Kara M. 
Published: August 2020

Objective Isolated fetal ventriculomegaly is often an incidental finding on antenatal ultrasound. It is benign in up to 90% of cases, although it can be associated with genetic, structural, and neurocognitive disorders. The literature suggests that over 40% of isolated mild ventriculomegaly will resolve in utero, but it is unclear if resolution decreases the associated risks.The aim of this study is to compare the fetal and neonatal genetic outcomes of ventriculomegaly that persists or resolves on subsequent ultrasound.
Study Design This is a retrospective cohort study of women diagnosed with isolated ventriculomegaly via fetal ultrasound at a tertiary referral center between 2011 and 2019. Patients were excluded if other structural anomalies were identified on ultrasound.
Results A total of 49 patients were included in the study, 19 in the resolved ventriculomegaly group and 30 in the persistent ventriculomegaly group. Women in the resolved ventriculomegaly group were more likely to be diagnosed earlier (24 vs. 28 weeks, p = 0.007). Additionally, they were more likely to have mild ventriculomegaly (63 vs. 84%, p = 0.15), and less likely to have structural neurological abnormalities diagnosed on postnatal imaging (5 vs. 17%, p = 0.384), although these were not statistically significant. Aneuploidy risk for resolved compared with persistent ventriculomegaly was similar (5 vs. 7%, p = 0.999).
Conclusion This study suggests that resolution of isolated ventriculomegaly in utero may not eliminate the risk of genetic or chromosomal abnormalities in this population and may warrant inclusion as part of the counselling of these at-risk patients. Larger prospective studies are needed to confirm these findings.
Key Points
Complications Associated with Low Position versus Good Position Umbilical Venous Catheters in Neonates of ≤32 Weeks' Gestation
Authors: Shahroor Maher , Maarouf Ahmad Mustafa , Yang Jie , Yankanah Rosanna , Shah Prakesh S. , Mohamed Adel 
Published: August 2020

Objective This study aimed to determine the incidence of umbilical venous catheter associated infection (UVCAI) in very preterm infants based on UVC tip position.
Study Design In this retrospective cohort study, infants born at ≤32 weeks were divided into groups with a UVC tip in either a low-lying or good position. The primary outcome was UVCAI. Survival analysis represented time to infection between groups. Subgroup analyses were based on duration of UVC indwelling time.
Results Of 1,983 infants, 1,638 infants were eligible; 33% had low-lying UVC and 67% had good position UVC. Survival analyses suggested a significantly higher probability of infection was associated with low UVC (adjusted hazard ratio [HR]: 1.9, 95% confidence interval [CI]: 1.1–3.2; p = 0.001). The risk of infection was higher for UVC of >7 days duration (adjusted HR: 2.2, 95% CI: 1.1–4.2). Extravasation as a complication was significantly higher in the low UVC versus good position UVC (1.3 vs. 0.1%; odds ratio: 14.4, 95% CI: 1.8–119).
Conclusion Low-lying UVC was associated with higher risk of infection and extravasation.
Key Points