bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in Health Care Utilization Patterns Among Inflammatory Bowel Disease Patients at Risk for High Medical Service Utilization Enrolled in High Deductible Health Plans
Authors: Berinstein Jeffrey A , Cohen-Mekelburg Shirley A , Steiner Calen A , McLeod Megan , Noureldin Mohamed , Allen John I , Kullgren Jeffrey T , Waljee Akbar K , Higgins Peter D R 
Published: July 2020

Abstract

Background
High-deductible health plans (HDHPs) are increasing in prevalence as a cost control device for slowing health care cost growth by reducing nonessential medical service utilization. High cost-sharing associated with HDHPs can lead to significant financial distress and worse disease outcomes. We hypothesize that chronic disease patients are delaying or foregoing necessary medical care due to health care costs.

Methods
A retrospective cohort analysis of IBD patients at risk for high medical service utilization with continuous enrollment in either an HDHP or THP from 2009 to 2016 were identified using the MarketScan database. Health care costs were compared between insurance plan groups by Kruskal-Wallis test. Temporal trends in office visits, colonoscopies, emergency department (ED) visits, and hospitalizations were evaluated using additive decomposition time series analysis.

Results
Of 605,862 patients with a diagnosis of IBD, we identified 13,052 eligible patients. Annual out-of-pocket costs were higher in the HDHP group (n = 524) than the THP group (n = 12,458) ($2870 vs $1,864; P &lt; 0.001) without any difference in total health care expenses ($23,029 vs $23,794; P = 0.583). Enrollment in an HDHP influenced colonoscopy, ED visit, and hospitalization utilization timing. Colonoscopies peaked in the fourth quarter, ED visits peaked in the first quarter, and hospitalizations peaked in the third and fourth quarter.

Conclusions
High-deductible health plan enrollment does not change the cost of care; however, it shifts health care costs onto patients and changes the timing of the care they receive. High-deductible health plans are incentivizing delays in obtaining health care with a potential to cause worse disease outcomes and financial distress. Further evaluation is warranted.
How storms affect fishers’ decisions about going to sea
Authors: Pfeiffer Lisa 
Published: July 2020

Abstract
Fishermen are known to try to avoid fishing in stormy weather, as storms pose a physical threat to fishers, their vessels, and their gear. In this article, a dataset and methods are developed to investigate the degree to which fishers avoid storms, estimate storm aversion parameters, and explore how this response varies across vessel characteristics and across regions of the United States. The data consist of vessel-level trip-taking decisions from six federal fisheries across the United States combined with marine storm warning data from the National Weather Service. The estimates of storm aversion can be used to parameterize predictive models. Fishers’ aversion to storms decreases with increasing vessel size and increases with the severity of the storm warning. This information contributes to our understanding of the risk-to-revenue trade-off that fishers evaluate every time they consider going to sea, and of the propensity of fishers to take adaptive actions to avoid facing additional physical risk.
Respiratory Syncytial Virus and All-Cause Bronchiolitis Hospitalizations Among Preterm Infants Using the Pediatric Health Information System (PHIS)
Authors: Fergie Jaime , Suh Mina , Jiang Xiaohui , Fryzek Jon P , Gonzales Tara 
Published: July 2020

Abstract

Background
In 2014, the American Academy of Pediatrics stopped recommending palivizumab to otherwise healthy 29–34 weeks’ gestational age (wGA) infants aged &lt;12 months at respiratory syncytial virus (RSV) season start. Here, we compare the burden of RSV hospitalizations (RSVH) and all-cause bronchiolitis hospitalizations (BH) before and after 2014 among otherwise healthy 29–34 wGA infants hospitalized at ≤6 months of age.

Methods
A historical, observational cohort study was conducted to evaluate RSVH and BH in 29–34 wGA infants during the 2010–2017 RSV seasons using encounter data from 51 United States children’s hospitals that comprise the Pediatric Health Information System.

Results
The overall cohort included 67 570 RSVH out of 96 281 patients with BH. wGA was known for 22 937 RSVH and 33 289 BH. For 29–34 wGA infants, there were 8.7% and 14.2% RSVH before and after 2014, respectively (P &lt; .0001). Intensive care unit admissions increased for RSVH (from 54.5% to 64.2%; P = .0002) and BH (from 46.7% to 54.5%; P = .0005) after controlling for sex, race, comorbidity, and cluster. The total cost of care increased for RSVH from $37 million to nearly $60 million.

Conclusions
RSVH, BH, and their severity increased among 29–34 wGA infants in the 3 RSV seasons following 2014.
Environmental Sampling for Severe Acute Respiratory Syndrome Coronavirus 2 During a COVID-19 Outbreak on the Diamond Princess Cruise Ship
Authors: Yamagishi Takuya , Ohnishi Makoto , Matsunaga Nobuaki , Kakimoto Kensaku , Kamiya Hajime , Okamoto Kiyoko , Suzuki Motoi , Gu Yoshiaki , Sakaguchi Mikiyo , Tajima Taichi , Takaya Saho , Ohmagari Norio , Takeda Makoto , Matsuyama Shuyoku , Shirato Kazuya , Nao Naganori , Hasegawa Hideki , Kageyama Tsutomu , Takayama Ikuyo , Saito Shinji , Wada Koji , Fujita Retsu , Saito Hiroki , Okinaka Keiji , Griffith Mathew , Parry Amy Elizabeth , Barnetson Brenda , Leonard James , Wakita Takaji 
Published: July 2020

Abstract
During a COVID-19 outbreak on the Diamond Princess cruise ship we sampled environmental surfaces after passengers and crew vacated cabins. SARS-CoV-2 RNA was detected in 58 of 601 samples (10%) from case cabins 1–17 days after cabins were vacated but not from noncase cabins. There was no difference in detection proportion between cabins of symptomatic (15%, 28/189; cycle quantification [Cq], 29.79–38.86) and asymptomatic cases (21%, 28/131; Cq, 26.21–38.99). No SARS-CoV-2 virus was isolated from any of the samples. Transmission risk of SARS-CoV-2 from symptomatic and asymptomatic patients may be similar and surfaces could be involved in transmission.
Continued In-Hospital Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use in Hypertensive COVID-19 Patients Is Associated With Positive Clinical Outcome
Authors: Lam Katherine W , Chow Kenneth W , Vo Jonathan , Hou Wei , Li Haifang , Richman Paul S , Mallipattu Sandeep K , Skopicki Hal A , Singer Adam J , Duong Tim Q 
Published: July 2020

Abstract

Background
This study investigated continued and discontinued use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) during hospitalization of 614 hypertensive laboratory-confirmed COVID-19 patients.

Methods
Demographics, comorbidities, vital signs, laboratory data, and ACEi/ARB usage were analyzed. To account for confounders, patients were substratified by whether they developed hypotension and acute kidney injury (AKI) during the index hospitalization.

Results
Mortality (22% vs 17%, P &gt; .05) and intensive care unit (ICU) admission (26% vs 12%, P &gt; .05) rates were not significantly different between non-ACEi/ARB and ACEi/ARB groups. However, patients who continued ACEi/ARBs in the hospital had a markedly lower ICU admission rate (12% vs 26%; P = .001; odds ratio [OR] = 0.347; 95% confidence interval [CI], .187–.643) and mortality rate (6% vs 28%; P = .001; OR = 0.215; 95% CI, .101–.455) compared to patients who discontinued ACEi/ARB. The odds ratio for mortality remained significantly lower after accounting for development of hypotension or AKI.

Conclusions
These findings suggest that continued ACEi/ARB use in hypertensive COVID-19 patients yields better clinical outcomes.
Determination of Oligofructose, a Soluble Dietary Fiber, by High-Temperature Capillary Gas Chromatography
Authors: Joye Dirk , Hoebregs Hubert 
Published: July 2020

Abstract
A high-temperature capillary gas chromatographic method was developed for the quantitative determination of oligofructose in foods and food products. Sample preparation involves oxymation and silylation of the extracted sugars. The oximetrimethylsilyl derivatives are analyzed on an apolar capillary column, with detection by flame ionization. The method is accurate, with recovery of spiked samples at &gt;96%. Repeatability was excellent; RSD values of 1.1% were obtained. Other common oligosaccharides, such as malto-, isomalto-, and galactooligosaccharides, and levan do not interfere, making the method specific and reliable.
Determination of Volatile Bases in Seafood Using the Ammonia Ion Selective Electrode: Collaborative Study
Authors: Ellis P Christopher , Pivarnik Lori F , Thiam Mamadou ,   Collaborators:, Berger L , Field S , Green D , Hewes D , Lemerise D , Lyttle C , Maciel J , Soper K 
Published: July 2020

Abstract
Nine collaborating laboratories tested a combination of 23 seafood samples for volatile bases using an ammonia ion selective electrode. Results were reported as mg NH3/100 g fish, but the method reflected levels of both ammonia and trimethylamine, which permeated the ammonia membrane. The 23 samples were broken down into 8 blind duplicate pairs, 2 Youden matched pairs, and 3 single samples covering fresh to spoiled product ranging from 8 to 82 mg NH3/100 g. Seven species were evaluated: Atlantic cod, squid, Atlantic halibut, gray sole, monkfish, dogfish, and Atlantic mackerel. The ammonia electrode assay was performed on an aqueous homogenate consisting of 95 mL distilled water and 5.0 g sample tissue. Alkaline ion strength adjusting solution (2 mL) was added to the homogenate to liberate ammonia that was sensed by the ion specific electrode and measured on a precalibrated portable meter. Repeatability standard deviations (RSDr) ranged from 4.2 to 17%; reproducibility standard deviations (RSDR) ranged from 8.8 to 21%. A standard ammonium chloride solution was provided to all laboratories to spike 3 different samples at 10 mg NH3/100 g. Recoveries of added ammonia as ammonium chloride for fresh, borderline, and spoiled samples were 88.6, 107, and 128%, respectively.
Improved Diffusion Methods for Nitrogen and 15Nitrogen Analysis of Kjeldahl Digests
Authors: Stevens W Bart , Mulvaney Richard L , Khan Saeed A , Hoeft Robert G 
Published: July 2020

Abstract
Simple methods are described that permit the use of either H3BO3 indicator solution or acidified filter disks to collect NH3 liberated by treatment of Kjeldahl digests with NaOH. These methods incorporate modifications to improve reliability, analytical capacity, and convenience. A semimicro digest was diluted to 25 mL with deionized water, and a 10 mL aliquot, containing up to 4 mg N (150 μg N for diffusions into acidified disks), was transferred to a shell vial, which was placed inside a 473 mL (1 pint) Mason jar containing 10 mL 10N NaOH. The NH3 liberated by overturning the vial was collected after 12 to 48 h at ambient temperature, or after 4 h at 45 to 50°C on a hotplate, for quantitative and/or isotope-ratio analyses. With either H3BO3 indicator solution or acidified filter disks, recovery of diffused N was quantitative. Isotope-ratio analyses of diffused N from 15N-labeled chemical, plant, and soil samples were within 3% of analyses using steam distillation.
Liquid Chromatographic Method with Electrochemical Detection for Determination of Cisapride in Serum
Authors: De Condado Maria C , Malave Andres , Dorantes-Hernandez Miguel A , Rathinavelu Appu 
Published: July 2020

Abstract
A sensitive liquid chromatographic (LC) method using electrochemical detection was developed for the identification and quantitation of cisapride in serum. The serum samples were deproteinized by a simple acetonitrile precipitation technique followed by n-hexane extraction. Cisapride in the deproteinized serum was separated by an isocratic elution with an ODS Hypersil LC column (150 × 4.6 mm) using a mobile phase consisting of 0.05M Na2HPO4–acetonitrile (60 + 40), pH 8.4. Cisapride eluted from the column was detected by a Coulochem II electrochemical detector. The precision of this assay method was determined by intra- and inter-day analyses of cisapride-free fetal bovine serum samples that were spiked with 25, 50, and 100 ng/mL cisapride. For the intra-day assay, recoveries were 94.3 ± 1.4, 90.1 ± 2.9, and 103.2 ± 9.2%, respectively. This electrochemical detection LC method could be very useful in monitoring plasma levels of cisapride.
Identification of Nile Perch (Lates niloticus), Grouper (Epinephelus guaza), and Wreck Fish (Polyprion americanus) Fillets by PCR Amplification of the 5S rDNA Gene
Authors: Asensio Luis , González Isabel , Fernández Alicia , Céspedes Ana , Rodríguez Miguel A , Hernández Pablo E , García Teresa 
Published: July 2020

Abstract
Nile perch (Lates niloticus), grouper (Epinephelus guaza), and wreck fish (Polyprion americanus) were differentiated by polymerase chain reaction (PCR) amplification of the nuclear 5S rDNA gene. The design of 3 species-specific primers complementary to the nontranscribed intergenic spacer region from the 5S rDNA molecule allowed amplification of clearly distinguishable gene fragments in each fish species. This approach is rapid and reliable and offers the potential to detect fraudulent or unintentional mislabeling of these species in routine seafood authentication analysis.
Certified Reference Material for Analytical Quality Assurance of Minor and Trace Elements in Food and Related Matrixes Based on a Typical Japanese Diet: Interlaboratory Study
Authors: Yoshinaga Jun , Morita Masatoshi , Yukawa Masae , Shiraishi Kunio , Kawamura Hisao ,   Collaborators:, Arae H , Baker S , Barnes R M , Dang H S , De Regge P , Funato Y , Futatsugawa K , Hirai S , Kato T , Kawamoto K , Matsubara M , Matsue H , Miller-Ihli N J , Muramatsu Y , Narukawa T , Okada Y , Reitznerová E , Sakamoto H , Sera K , Shindo K , Suzuki S , Takata J , Takeuchi T , Tamari Y , Tanizaki Y , Veillon C , Yasui A , Yonezawa C 
Published: July 2020

Abstract
A Certified Reference Material (CRM) was prepared at the National Institute for Environmental Studies (NIES), Japan, in collaboration with the National Institute of Radiological Sciences (NIRS), Japan, for the analytical quality assurance of minor and trace elements in food and related matrixes. The starting material for the CRM was all food served in 29 households in Japan over two 3-day periods in 1997–1998, and thus the CRM represented a typical Japanese diet. All foods (meals, snacks, and beverages) were homogenized, freeze-dried, pulverized, blended, dispensed into 1100 bottles, and sterilized. The within- and between-bottle homogeneity of the prepared CRM was satisfactory for most of the elements. The concentrations of 14 elements (Na, Mg, K, Ca, Mn, Cu, Zn, As, Se, Sr, Cd, Sn, Ba, and U) were certified based on a collaborative analysis involving NIES, NIRS, and 20 other laboratories. Reference values were given for the concentrations of 12 additional elements (P, Cl, Fe, Co, Ni, Br, Rb, Mo, I, Cs, Pb, and Th). The elements certified and those given reference values include minerals, essential trace elements, contaminant elements, and long-lived radionuclides. Thus, this CRM is of practical value in the quality assurance of element analysis of foods and diets in nutritional, environmental, and radiological research.
Improved Method for Determination of Abamectin and Ivermectin in Cattle Plasma
Authors: Wei Guang Zhi , Li Jun Suo 
Published: July 2020

Abstract
A liquid chromatographic (LC) method was developed for determination of abamectin (ABM) and ivermectin (IVM) in cattle plasma. The sample was extracted with acetonitrile and cleaned up on an alumina column. After conversion to stable fluorescent derivative with trifluoroacetic anhydride and N-methylimidazole, the sample was analyzed by LC with fluorescence detection (Ex 365 nm and Em 475 nm). Doramectin was used as an internal standard. Recoveries ranged from 91.2 to 100.7% for IVM and from 87.0 to 98.7% for ABM, with 1–50 ng/mL fortified samples. The coefficients of variation were &lt;10.1%. The limit of detection was 0.02 ng/mL for ABM and IVM in 1.0 mL samples.
Determination of Organochlorinated Compounds in Marine Organisms by Microwave-Assisted Extraction with Molecular Organized Systems and Liquid Chromatography with Fluorescence Detection
Authors: Sanz Carolina Padrón , Fernández Arantza Eiguren , Ferrera Zoraida Sosa , Rodríguez Jose Juan Santana 
Published: July 2020

Abstract
Microwave-assisted extraction methodology is used to extract different compounds from various kinds of marine solid samples, such as soils, sediments, and organisms. A new analytical method was developed to extract polychlorinated biphenyls and polychlorinated dibenzofurans by using a conventional microwave system and the nonionic surfactant, polyoxyethylene 10 lauryl ether as the extractant as a prior step to liquid chromatography analysis coupled with fluorescence detection. The method was applied to the extraction and determination of these analytes in samples of blue mussels (Mytilus galloprovincialis), cockles (Cerastoderma edule), and clams (Dosinia exoleta). Compared with the traditional Soxhlet extraction, results of the proposed method showed acceptable recovery percentages for the organochlorinated compounds under study and standard deviation values &lt;10%.
Multiresidue Determination of Pesticides in Drinking and Related Waters by Solid-Phase Extraction and Liquid Chromatography with Ultraviolet Detection: Interlaboratory Study
Authors: Hoof François van , Wiele Peter van , Acobas Françoise , Guinamant Jean-Luc , Bruchet Auguste , Schmitz Isabelle , Bobeldijk Ivana , Sacher Frank , Ventura Francesc ,   Collaborators:, Alterova K , Barcelo D , Barnier A , De Buyzer C , Mérard G , Hajslova J , Marti I , Martinez K , Planas C , Pussemier L , Rivera J , Oörden R , Tejedor A , van der Kreeft R , Vanermen G , Walravens E , Werres F , Wouters E 
Published: July 2020

Abstract
As part of a project funded by the European Commission (EC) for the development and evaluation of multiresidue methods for analysis of drinking and related waters, 17 European laboratories evaluated a method using styrene–divinylbenzene copolymer solid-phase extraction followed by liquid chromatography with diode array detection. The main aim of the study was to evaluate whether the method meets the requirements of EC Drinking Water Directive 98/83 in terms of accuracy, precision, and detection limit for 21 pesticides according to the following requirements: limit of detection, ≤0.025 μg/L; accuracy expressed as recovery, between 75 and 125%; and precision expressed as repeatability relative standard deviation of the method, &lt;12.5%, and as reproducibility relative standard deviation of the method, &lt;25%. Analyses for unknown concentrations were performed with commercial bottled and tap waters. All laboratories were able to achieve detection limits of 0.01 μg/L for all pesticides except pirimicarb (0.02 μg/L). The criteria for repeatability were met for all compounds. Terbutryn in bottled water and carbendazim in tap water did not meet the criteria for reproducibility. In terms of accuracy, the method met the requirements for all pesticides in both matrixes, except for metamitron. However, several compounds (linuron, terbutryn, propazine, metobromuron, and isoproturon) showed recoveries slightly below 75%.
Interlaboratory Comparison of Methods for the Determination of Incurred Tilmicosin Residues in Bovine Liver
Authors: Clark Susan B , O'rangers John J , Rowe W Douglas , Madson Mark R , Hurlbut Jeffrey A , Sofos John N , Fuerst Brenda , James Glenda , Griffith Sydney , Readnour Robin S 
Published: July 2020

Abstract
The objective of this study was to compare 2 methods for the determination of tilmicosin residues in bovine liver samples. Three laboratories participated in the comparison of the 2 methods. The first method was described in a New Animal Drug Application (NADA 140–929), and the second was a modification of that method in which hexane was substituted for carbon tetrachloride in one cleanup step. Each of the 3 laboratories analyzed subsamples of 10 bovine livers containing incurred tilmicosin. Residues ranged from 2.3 to 81 ppm tilmicosin in the 10 liver samples with an 11.8% relative standard deviation obtained by using both methods. In addition, fortified-control liver tissue samples were analyzed concurrently with tissues containing incurred residues by using the modified method in one of the laboratories. The fortification levels ranged from 0.3 to 112 ppm, with recoveries ranging from 76 to 92%. The results from the 3 laboratories were comparable, indicating that the modified method was not only as effective as the original NADA method, but also more desirable because of the change to a less hazardous solvent.
A Gas Chromatographic Determination of Residues of Eleven Insecticides and Two Metabolites on Olive Tree Leaves
Authors: Aplada-Sarlis Pipina , Miliadis George E , Liapis Konstantinos , Tsiropoulos Nicholas G 
Published: July 2020

Abstract
A gas chromatographic (GC) method was developed and statistically validated for the simultaneous determination of residues of pyrethroid, endosulfan, and organophosphorus insecticides and some of their metabolites on olive tree leaves. Pesticide residues were extracted by static extraction with acetone–dichloromethane. After evaporation of the extract to dryness and redissolution in acetone, the organophosphorus insecticides were determined by GC with nitrogen–phosphorus detection. Another portion of the extract, after solvent change to acetonitrile, was cleaned up on an Alumina-N cartridge and analyzed for insecticides sensitive to electron-capture detection (ECD), i.e., pyrethroids and endosulfan and its metabolite. Recoveries of the organophosphorus insecticides ranged from 80.7 to 93.3% with relative standard deviations (RSDs) of ≤ 7.2%; recoveries of the ECD-sensitive insecticides ranged from 71.6 to 89.5% with RSDs of ≤ 11.6%. The method was used to analyze 26 samples of olive tree leaves from organic olive groves all over Greece, and the results confirmed the viability of the method for routine analysis. Residues of fenthion and fenthion sulfoxide were found in one and 3 samples, respectively, and their identities were confirmed by GC with mass spectrometry.