bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral medialization thyroplasty in patients with vocal fold atrophy with or without sulcus
Authors: van den Broek Emke M. J. M. , Heijnen Bas J. , Hendriksma Martine , van de Kamp-Lam Vivienne A. H. , Verhagen Thijs O. , Langeveld Antonius P. M. , van Benthem Peter Paul G. , Sjögren Elisabeth V. 
Published: April 2020

Abstract
Purpose
To evaluate voice outcome after bilateral medialization thyroplasty in patients with non-paralytic glottic insufficiency due to vocal fold atrophy with or without sulcus.

Methods
Retrospective cohort study on 29 patients undergoing bilateral medialization thyroplasty for vocal fold atrophy (14 procedures) or atrophy with sulcus (15 procedures) between October 2012 and November 2017. Voice data were collected and analyzed for the preoperative and the 3- and 12-month postoperative time point according to a standardized protocol, including Voice Handicap Index (VHI)-30 and perceptual, acoustic and aerodynamic parameters. Failure rate was based on number of revisions within 12 months and non-relevant improvement (< 10 points) in VHI-30 at 12 months.

Results
There was a clinically relevant (≥ 15 points) and statistically significant improvement (p < 0.0001) in the VHI-30 (preoperative: 55.8 points; postoperative at 12 months: 30.9 points). Fundamental frequency for male subjects decreased significantly from 175 to 159 Hz (p = 0.0001). The pre- and post-operative grade of dysphonia was significantly lower in patients with atrophy compared to atrophy and sulcus (mean difference 0.70, p = 0.017).

Conclusion
Bilateral medialization thyroplasty is a valid treatment option for patients with atrophy with or without sulcus. Outcomes are comparable to other methods reported in literature. However, there is a great need for larger, prospective studies with long-term follow-up to gain more insight into the comparative voice outcomes for the different forms of surgery for patients with glottic incompetence due to atrophy with or without sulcus.
Interventions for common mental disorders in the occupational health service: a systematic review with a narrative synthesis
Authors: Axén Iben , Björk Brämberg Elisabeth , Vaez Marjan , Lundin Andreas , Bergström Gunnar 
Published: April 2020

Abstract
Introduction
Common mental disorders (CMD) are leading causes of decreased workability in Sweden and worldwide. Effective interventions to prevent or treat such disorders are important for public health.

Objective
To synthesize the research literature regarding occupational health service (OHS) interventions targeting prevention or reduction of CMD among employees. The effect on workability (sickness absence, return-to-work and self-reported workability) and on CMD symptoms was evaluated in a narrative analysis.

Data sources
The literature search was performed in four electronic databases in two searches, in 2014 and in 2017.

Eligibility criteria (using PICO)
Population: studies investigating employees at risk or diagnosed with CMD, as well as preventive workplace intervention targeting mental health. Intervention: studies where the recruitment or the intervention was delivered by the OHS or OHS personnel were included. Control: individuals or groups who did not receive the target intervention. Outcome: all types of outcomes concerning sickness absence and psychological health were included.
Study quality was assessed using a Swedish AMSTAR-based checklist, and results from studies with low or medium risk of bias were narratively synthesized based on effect or absence thereof.

Results
Thirty-three studies were included and assessed for risk of bias. Twenty-one studies had low or medium risk of bias. In 18 studies, rehabilitation interventions were evaluated, 11 studies concerned interventions targeting employees at risk for developing CMD and four studies investigated preventive interventions. Work-focused cognitive behavioral therapy and problem-solving skill interventions decreased time to first return-to-work among employees on sick leave for CMD in comparison with treatment-as-usual. However, effect on return to full-time work was not consistent, and these interventions did not consistently improve CMD symptoms. Selective interventions targeting employees at risk of CMD and preventive interventions for employees were heterogeneous, so replication of these studies is necessary to evaluate effect.

Limitations
Other workplace interventions outside the OHS may have been missed by our search. There was considerable heterogeneity in the included studies, and most studies were investigating measures targeting the individual worker. Interventions at the workplace/organizational level were less common.

Conclusions and implication of key findings
Return-to-work and improvement of CMD symptoms are poorly correlated and should be addressed simultaneously in future interventions. Further, interventions for CMD administered through the occupational health service require further study. Rehabilitative and preventive strategies should be evaluated with scientifically robust methods, to examine the effectiveness of such interventions.
A review on impedimetric immunosensors for pathogen and biomarker detection
Authors: Leva-Bueno J. , Peyman Sally A. , Millner P. A. 
Published: April 2020

AbstractSince the discovery of antibiotics in the first quarter of the twentieth century, their use has been the principal approach to treat bacterial infection. Modernized medicine such as cancer therapy, organ transplantation or advanced major surgeries require effective antibiotics to manage bacterial infections. However, the irresponsible use of antibiotics along with the lack of development has led to the emergence of antimicrobial resistance which is considered a serious global threat due to the rise of multidrug-resistant bacteria (Wang et al. in Antibiotic resistance: a rundown of a global crisis, pp. 1645–1658, 2018). Currently employed diagnostics techniques are microscopy, colony counting, ELISA, PCR, RT-PCR, surface-enhanced Raman scattering and others. These techniques provide satisfactory selectivity and sensitivity (Joung et al. in Sens Actuators B Chem 161:824–831, 2012). Nevertheless, they demand specialized personnel and expensive and sophisticated machinery which can be labour-intensive and time-consuming, (Malvano et al. in Sensors (Switzerland) 18:1–11, 2018; Mantzila et al. in Anal Chem 80:1169–1175, 2008). To get around these problems, new technologies such as biosensing and lab-on-a-chip devices have emerged in the last two decades. Impedimetric immunosensors function by applying electrochemical impedance spectroscopy to a biosensor platform using antibodies or other affinity proteins such as Affimers (Tiede et al. in Elife 6(c):1–35, 2017) or other binding proteins (Weiss et al. in Electrochim Acta 50:4248–4256, 2005) as bioreceptors, which provide excellent sensitivity and selectivity. Pre-enrichment steps are not required and this allows miniaturization and low-cost. In this review different types of impedimetric immunosensors are reported according to the type of electrode and their base layer materials, either self-assembled monolayers or polymeric layers, composition and functionalization for different types of bacteria, viruses, fungi and disease biomarkers. Additionally, novel protein scaffolds, both antibody derived and non-antibody derived, used to specifically target the analyte are considered.
EmoteControl: an interactive system for real-time control of emotional expression in music
Authors: Micallef Grimaud Annaliese , Eerola Tuomas 
Published: April 2020

AbstractSeveral computer systems have been designed for music emotion research that aim to identify how different structural or expressive cues of music influence the emotions conveyed by the music. However, most systems either operate offline by pre-rendering different variations of the music or operate in real-time but focus mostly on structural cues. We present a new interactive system calledEmoteControl, which allows users to make changes to both structural and expressive cues (tempo, pitch, dynamics, articulation, brightness, and mode) of music in real-time. The purpose is to allow scholars to probe a variety of cues of emotional expression from non-expert participants who are unable to articulate or perform their expression of music in other ways. The benefits of the interactive system are particularly important in this topic as it offers a massive parameter space of emotion cues and levels for each emotion which is challenging to exhaustively explore without a dynamic system. A brief overview of previous work is given, followed by a detailed explanation ofEmoteControl’s interface design and structure. A portable version of the system is also described, and specifications for the music inputted in the system are outlined. Several use-cases of the interface are discussed, and a formal interface evaluation study is reported. Results suggested that the elements controlling the cues were easy to use and understood by the users. The majority of users were satisfied with the way the system allowed them to express different emotions in music and found it a useful tool for research.
Determination of the target population in early benefit assessments in Germany: challenges for non-small-cell lung cancer
Authors: ten Thoren C. , Balg C. , Gibbert J. , Mostardt S. , Ripoll M. , Schierbaum D. , Schiller S. , Schwalm A. 
Published: April 2020

AbstractObjectivesDossiers submitted for early benefit assessments in Germany also provide information on the precise determination of the target population (patients eligible for a drug). The situation is complex for non-small-cell lung cancer (NSCLC) due to highly specific therapeutic indications. Our aim was to compare the different methodological steps applied to determine the target population in dossiers on drugs for NSCLC.MethodsWe analysed NSCLC dossiers assessed by the German Institute for Quality and Efficiency in Health Care (IQWiG) between 01.01.2011 and 31.12.2017. Methodological details regarding the determination of the target population were extracted and compared.ResultsWe analysed 23 NSCLC dossiers. In all dossiers, the target population was determined using the number of all patients with lung cancer as the basis for calculations. This patient population was further reduced in several successive steps by assuming proportions of patients with a specific characteristic (e.g. disease stage). The most important calculation steps were patients with NSCLC (n = 23 dossiers), with a specific disease stage (n = 23), with a specific tumour mutation (n = 14), with a specific tumour histology (n = 7), without prior treatment (n = 15), with pretreatment in second or further treatment lines (n = 17), and/or with specific pretreatments (n = 9). The proportions of patients determined within the same calculation step varied considerably between dossiers.DiscussionThe calculation methods applied and the target population sizes reported in NSCLC dossiers vary considerably. A consensus with regard to the databases and calculation methods used to determine the target population in NSCLC would be helpful to reduce variations.
Towards a Universal Pension Points System in France
Authors: Boulhol Hervé 
Published: April 2020

AbstractA specificity of the current French system is that a private sector worker is currently covered by two mandatory public pay-as-you-go (PAYGO) schemes: a general defined benefit (DB) scheme — which is the main component — managed by the state and a points scheme (AgircArrco) managed by social partners, together representing about 70% of paid benefits.
GNSS code and carrier phase observations of a Huawei P30 smartphone: quality assessment and centimeter-accurate positioning
Authors: Wanninger Lambert , Heßelbarth Anja 
Published: April 2020

AbstractIn 2016, an application programming interface was added to the Android operating systems, which enables the access of GNSS raw observations. Since then, an in-depth evaluation of the performance of smartphone GNSS chips is very much simplified. We analyzed the quality of the GNSS observations, especially the carrier phase observations, of the dual-frequency GNSS chip Kirin 980 built into Huawei P30 and other smartphones. More than 80 h of static observations were collected at several locations. The code and carrier phase observations were processed in baseline mode with reference to observations of geodetic-grade equipment. We were able to fix carrier phase ambiguities for GPS L1 observations. Furthermore, we performed an antenna calibration for this frequency, which revealed that the horizontal phase center offsets from the central vertical axis of the smartphone and also the phase center variations do not exceed 1–2 cm. After successful ambiguity fixing, the 3D position errors (standard deviations) are smaller 4 cm after 5 min of static observation session and 2 cm for long observation session.
Teachers as brokers: adding a university-society perspective to higher education teacher competence profiles
Authors: Oonk Carla , Gulikers Judith T. M. , den Brok Perry J. , Wesselink Renate , Beers Pieter-Jelle , Mulder Martin 
Published: April 2020

AbstractHigher education institutions are increasingly engaged with society but contemporary higher education teacher competence profiles do not include university-society oriented responsibilities of teachers. Consequently, comprehensive insights in university-society collaborative performance of higher education teachers are not available. This study empirically develops a teacher profile for an exemplary university-society oriented, multi-stakeholder learning environment and builds an argument for university-society collaborative additions to existing higher education teacher profiles. A showcase example of a new university-society collaborative, multi-stakeholder learning environment, the Regional Learning Environment (RLE), provides the context of analysis. Thirteen RLE establishments were included in the study. The study uses a descriptive qualitative design, triangulating data from RLE documents, teacher interviews and focus groups with teachers and managers on RLE teacher roles, tasks and competencies. The resulting RLE teacher profile comprises nine roles, nineteen tasks and 21 competencies. The new profile echoes scattered indications for teacher responsibilities as identified in previous studies on teaching and learning in university-society collaborative learning settings. The study argues that the role of broker, including boundary crossing competence, and the competency ‘stimulating a collaborative learning attitude’, might be added to existing higher education teacher competence profiles. Adding this university-society engaged perspective to existing teacher competence profiles will support higher education institutions in developing their university-society collaborative responsibilities and subsequent teacher professionalisation trajectories.
Sanggenon C Ameliorates Cerebral Ischemia-Reperfusion Injury by Inhibiting Inflammation and Oxidative Stress through Regulating RhoA-ROCK Signaling
Authors: Zhao Yilei , Xu Jingfeng 
Published: April 2020

Abstract
Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model of reversible middle cerebral artery occlusion (MCAO) was used to induce cerebral I/R injury in vivo, and SC was administrated intragastrically. Brain injuries were evaluated using Bederson scores, brain water content, and 2, 3, 5-triphenyltetrazolium chloride (TTC) staining. The levels of inflammatory factors and oxidative stress were examined using corresponding kits. Cell apoptosis was evaluated by TUNEL. Moreover, the expressions of apoptosis-related and RhoA/ROCK signaling-related proteins were detected through western blotting. In vitro, RhoA was overexpressed in oxygen-glucose deprivation and reperfusion (OGD/R)-induced PC12 cells to confirm the contribution of RhoA-ROCK signaling inhibition by SC to the neuroprotective effects post OGD/R. Pretreatment with SC significantly ameliorated the neurologic impairment, brain edema, and cerebral infarction post MCAO-reperfusion, associated with reductions of inflammation, oxidative stress, and cell apoptosis in the brain. Furthermore, SC remarkably downregulated the expression of RhoA/ROCK signaling-related proteins post MCAO-reperfusion in rats, while overexpression of RhoA reversed the beneficial effects of SC on protecting against inflammation and oxidative stress in OGD/R-induced PC12 cells. Taken together, these findings demonstrated that SC exerts neuroprotective effects after cerebral I/R injury via inhibiting inflammation and oxidative stress through regulating RhoA-ROCK signaling, suggesting a therapeutic potential of SC in cerebral I/R injury.
Chemical Mediation of Oviposition by Anopheles Mosquitoes: a Push-Pull System Driven by Volatiles Associated with Larval Stages
Authors: Schoelitsz Bruce , Mwingira Victor , Mboera Leonard E. G. , Beijleveld Hans , Koenraadt Constantianus J. M. , Spitzen Jeroen , van Loon Joop J. A. , Takken Willem 
Published: April 2020

AbstractThe oviposition behavior of mosquitoes is mediated by chemical cues. In the malaria mosquito Anopheles gambiae, conspecific larvae produce infochemicals that affect this behavior. Emanations from first instar larvae proved strongly attractive to gravid females, while those from fourth instars caused oviposition deterrence, suggesting that larval developmental stage affected the oviposition choice of the female mosquito.We examined the nature of these chemicals by headspace collection of emanations of water in which larvae of different stages were developing. Four chemicals with putative effects on oviposition behavior were identified: dimethyldisulfide (DMDS) and dimethyltrisulfide (DMTS) were identified in emanations from water containing fourth instars; nonane and 2,4-pentanedione (2,4-PD) were identified in emanations from water containing both first and fourth instars. Dual-choice oviposition studies with these compounds were done in the laboratory and in semi-field experiments in Tanzania.In the laboratory, DMDS and DMTS were associated with oviposition-deterrent effects, while results with nonane and 2,4-PD were inconclusive. In further studies DMDS and DMTS evoked egg retention, while with nonane and 2,4-PD 88% and 100% of female mosquitoes, respectively, laid eggs. In dual-choice semi-field trials DMDS and DMTS caused oviposition deterrence, while nonane and 2,4-PD evoked attraction, inducing females to lay more eggs in bowls containing these compounds compared to the controls. We conclude that oviposition of An. gambiae is mediated by these four infochemicals associated with conspecific larvae, eliciting either attraction or deterrence. High levels of egg retention occurred when females were exposed to chemicals associated with fourth instar larvae.
Determination of the crystallization mechanism of glasses in the system BaO/SrO/ZnO/SiO2 with differential scanning calorimetry
Authors: Thieme Katrin , Thieme Christian 
Published: April 2020

AbstractIn order to identify suitable volume nucleation agents in glasses, heat treatments and subsequent traditional microscopic investigations are necessary. Those analyses are laborious and time-consuming. Therefore, often DSC methods are used to get information about the preferred crystallization mechanism or adequate nucleation and growth temperatures. In principle, these non-isothermal methods are much faster. In this study, different glasses from the system BaO–SrO–ZnO–SiO2 were prepared. The pairs show only slight compositional variations but a clearly different crystallization behavior. Each pair consists of one glass, which shows volume crystallization and another one, which crystallizes solely at the surface. The DSC results are correlated with the microstructures of the glass ceramics obtained from microscopic studies. It is shown that conventional DSC methods cannot give a distinct answer which crystallization mechanism really exists. One method was identified to securely determine the crystallization mechanism.
Multivariate Outlier Detection in Applied Data Analysis: Global, Local, Compositional and Cellwise Outliers
Authors: Filzmoser Peter , Gregorich Mariella 
Published: April 2020

AbstractOutliers are encountered in all practical situations of data analysis, regardless of the discipline of application. However, the term outlier is not uniformly defined across all these fields since the differentiation between regular and irregular behaviour is naturally embedded in the subject area under consideration. Generalized approaches for outlier identification have to be modified to allow the diligent search for potential outliers. Therefore, an overview of different techniques for multivariate outlier detection is presented within the scope of selected kinds of data frequently found in the field of geosciences. In particular, three common types of data in geological studies are explored: spatial, compositional and flat data. All of these formats motivate new outlier concepts, such as local outlyingness, where the spatial information of the data is used to define a neighbourhood structure. Another type are compositional data, which nicely illustrate the fact that some kinds of data require not only adaptations to standard outlier approaches, but also transformations of the data itself before conducting the outlier search. Finally, the very recently developed concept of cellwise outlyingness, typically used for high-dimensional data, allows one to identify atypical cells in a data matrix. In practice, the different data formats can be mixed, and it is demonstrated in various examples how to proceed in such situations.
High expression of estrogen receptor alpha and aromatase in glial tumor cells is associated with gender-independent survival benefits in glioblastoma patients
Authors: Hönikl Lisa Stefanie , Lämmer Friederike , Gempt Jens , Meyer Bernhard , Schlegel Jürgen , Delbridge Claire 
Published: April 2020

Abstract
Introduction
Glioblastoma multiforme (GBM) is a highly malignant glial tumor, affecting men more often than women. The reason for this gender-specific predominance remains unclear, raising the question whether these effects are subject to hormonal control. The purpose of this study was to examine the expression of estrogen receptor alpha (ERα) and aromatase in human GBM tissue samples in relation to patient survival and furthermore to investigate the effect of standard chemotherapy in combination with estradiol treatment on glioblastoma tumor cell lines in vitro.

Methods
60 tissue samples (31 male, 29 female) of GBM patients were analysed with immunohistochemistry for ERα and aromatase for survival analyses. The cell lines LN18 and LN229 were treated with 17β-estradiol (E2) in different dosing regimens and the cell viability was measured with MTT assay. After estradiol pre-treatment Temozolomide was added and tested again.

Results
High expression of ERα and aromatase in the GBM tissue samples was associated with significantly longer survival times of GBM patients, regardless of gender and body-mass-index. The treatment with high concentrations of estradiol resulted in lower tumor cell viability, compared to control. The cells significantly showed a stronger sensitivity against Temozolomid (TMZ) after estradiol pre-treatment.

Conclusion
ERα-expression of glial tumour cells seems to play an important prognostic role as a biomarker in GBM, as well as the expression of the enzyme Aromatase. The combined treatment of GBM with standard chemotherapy and estradiol may be beneficial to patient’s survival.