bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative acetylome analysis reveals involvement of glucosyltransferase acetylation in Streptococcus mutans biofilm formation
Authors: Lei Lei , Zeng Jumei , Wang Lingyun , Gong Tao , Zheng Xin , Qiu Wei , Zhang Ru , Yun Libing , Yang Yingming , Li Yuqing 
Published: November 2020

SummaryStreptococcus mutans (S. mutans) effectively utilizes dietary sucrose for the exopolysaccharide productions, which are mostly synthesized by the effects of glucosyltransferases (Gtfs). In the present study, the acetylome of S. mutans was identified and quantitative acetylome analysis of the bacterial biofilm growth (SMB) was compared with that of planktonic growth (SMP). The dynamic changes of protein acetylation were quantified using the integrated approach involving TMT labeling and Kac affinity enrichment followed by high‐resolution mass spectrometry‐based quantitative proteomics. In total, 973 acetylation sites in 445 proteins were identified, among which 617 acetylation sites in 302 proteins were quantitated. The overall analysis indicated that 22.7% of proteins were acetylated. Among the quantified proteins in SMB, the acetylation degree of lysine in 56 sites increased, while that of lysine decreased in 52 sites. In the acetylome of S. mutans, six significantly enriched motifs were identified and obtained including Kac****K, KacF, Kac****R, KacY, KacH, F*Kac. In addition, KEGG pathway‐based enrichment analysis indicated significant enrichments in glycolysis/gluconeogenesis, and RNA degradation. Particularly, most downregulated acetylated lysine proteins were glucosyltransferase‐SI, glucosyltransferase‐I, and glucosyltransferase‐S in S. mutans biofilm, which probably reveals a switch‐off mechanism for the regulation of glucosyltransferases function during the biofilm development.
Perceptions of current occupational therapy practice with older adults experiencing delirium
Authors: Strecker Cheri , Hitch Danielle 
Published: November 2020

AbstractObjectivesTo describe the perceptions of Australian occupational therapists of their role, knowledge and skills in enabling older adults with delirium to participate in meaningful occupations.MethodsThis is a mixed‐methods cross‐sectional study. Participants (n = 91) completed an online survey, with quantitative data analysed descriptively and qualitative data subjected to content analysis.ResultsOccupational therapists had good general delirium knowledge, but less understanding of specific risk factors. Participants asserted the importance of occupational therapy assessment and treatment for older people experiencing delirium and generally felt confident or somewhat confident in their skills. While all participants provided collaborative care with multidisciplinary team members, only a minority thought colleagues had a satisfactory knowledge of the occupational therapy role with delirium.ConclusionCurrently, the role of occupational therapy with older people experiencing delirium remains emerging rather than established, and there are many opportunities for further research and development in this practice area.
A Low‐Intensity, High‐Frequency Intervention to Reduce Procrastination
Authors: Wessel Jason , Bradley Graham L. , Hood Michelle 
Published: November 2020

Studies assessing the efficacy of interventions aimed at reducing procrastination have generally lacked robust longitudinal measurement tools. Recent developments in communication technology and applications of the Experience Sampling Method (ESM) have made observations of such dynamic phenomena possible. We leveraged recent advancements in smartphone technology and ESM to measure delay associated with procrastination, while testing a low‐intensity, high‐frequency intervention to reducing that delay. First‐year university students (N = 107) reported their progress on an assignment twice daily over 14 days prior to the required submission date. Half (n = 51) were randomly allocated to an intervention condition in which they were also asked open‐ended questions designed to prompt reflection on four domains proposed to reduce procrastination, namely: expectancy, value, delay sensitivity, and metacognition. Multilevel mixed effect models revealed lower behavioral delay in the intervention condition compared to the control condition. This effect was strongest in those who at baseline scored below the median on trait procrastination. Behavioral delay over the 14‐day period was not associated with later assignment submission or lower assignment marks. These findings support a novel method for reducing delay and suggest procrastination can be alleviated in a wide range of contexts using relatively inexpensive and non‐intrusive strategies.
A novel heterozygous variant in FGF9 associated with previously unreported features of multiple synostosis syndrome 3
Authors: Thuresson Ann‐Charlotte , Croft Brittany , Hailer Yasmin D. , Liminga Gunnar , Arvidsson Carl‐Göran , Harley Vincent R. , Stattin Eva‐Lena 
Published: November 2020

AbstractHuman multiple synostoses syndrome 3 is an autosomal dominant disorder caused by pathogenic variants in FGF9. Only two variants have been described in FGF9 in humans so far, and one in mice. Here we report a novel missense variant c.566C > G, p.(Pro189Arg) in FGF9. Functional studies showed this variant impairs FGF9 homodimerization, but not FGFR3c binding. We also review the findings of cases reported previously and report on additional features not described previously.
Effect of volatile anesthetics on early and delayed outcomes in pancreas transplantation
Authors: Atoa Sam M. , Mangus Richard S. , Graham Ryan C. , Kroepfl Elizabeth A. , Powelson John A. , Fridell Jonathan A. 
Published: November 2020

AbstractBackgroundIschemia‐reperfusion injury (IRI) is a common cause of allograft dysfunction and patient morbidity in solid organ transplantation. This study compares the effect of different inhaled anesthetics on early IRI and clinical outcomes in pancreas allograft recipients.MethodsData were extracted retrospectively for pancreas transplants at a single center over a 15‐year period. Early postoperative pancreatic amylase and lipase levels were used as a marker for graft injury. Clinical outcomes measured included length of hospital stay, readmission, and graft survival.ResultsThere were 625 pancreas transplants included in the analysis with 3 primary inhaled anesthetics: sevoflurane (53%), desflurane (35%), and isoflurane (12%). In the first 30 days post‐transplant, peak amylase was lowest for sevoflurane (147) followed by desflurane (159) and isoflurane (229) (p = .03). Peak lipase levels followed the same trend (peak values 118, 131, and 135, respectively; p = .02). Early graft loss, length of hospital stay, and readmission within 3 months were similar among all three anesthetic groups. There was no difference in 10‐year graft survival by Cox regression.ConclusionsSevoflurane and desflurane are associated with lower peak amylase and lipase levels postoperatively in pancreas transplantation. Short‐ and long‐term clinical outcomes were equivalent for the three agents.
Craniofacial and dental injuries associated with stand‐up electric scooters
Authors: Kim Minsik , Lee Soyeon , Ko Dong Ryul , Kim Dae‐Hoon , Huh Jong‐Ki , Kim Jae‐Young 
Published: November 2020

AbstractBackground/AimWith the recent increased share of stand‐up electric scooters (e‐scooters), it is common to see people riding e‐scooters on the roads in Korea. The aim of this study was to investigate traumatic injuries to the craniofacial region related to e‐scooter accidents and to determine the role of dentists (especially oral and maxillofacial surgeons) in the evaluation of patients with trauma at the emergency department due to an e‐scooter accident.Materials and MethodsThis retrospective study investigated the medical records of patients who visited the Gangnam Severance Hospital Emergency Care Center for trauma related to e‐scooter use from January 1, 2017 to March 31, 2020. Medical records were reviewed to determine the injuries sustained to the craniofacial region related to e‐scooter use, including location of the injury (eg, cranium, craniofacial bone, teeth, soft tissue) and the type of trauma (eg, fracture, laceration, abrasion, contusion, concussion).ResultA total of 256 patients' medical records were evaluated. Among them, 125 patients (48.8% of all patients) had sustained craniofacial trauma. Laceration (n = 56, 44.8%) was the most common type of craniofacial injury, followed by cerebral concussion (n = 49, 39.2%), dental injury (n = 27, 21.6%), and craniofacial bone fracture (n = 16, 12.8%).ConclusionDentists should always consider the possibility of brain trauma and perform a complete craniofacial and oral examination when assessing patients after e‐scooter accidents as outlined by the International Association of Dental Traumatology guidelines. Additionally, it is necessary to educate e‐scooter riders about the importance of wearing protective devices, such as helmets, to reduce the risk of injuries to the craniofacial region.
Toolkit for assessing and addressing cognitive health in early psychosis: Evaluation of feasibility and utility in a coordinated specialty care setting
Authors: Saperstein Alice M. , Medalia Alice , Malinovsky Igor , Bello Iruma , Dixon Lisa B. 
Published: November 2020

AbstractAimMethods to identify and harness individual cognitive strengths while addressing relative weaknesses have the potential to complement recovery services for first‐episode psychosis but systematic implementation is needed. We developed a cognitive health toolkit, trained teams from OnTrackNY, a network of coordinated specialty care (CSC) programs and examined toolkit feasibility and clinical utility during the first year of roll‐out.MethodsThe toolkit includes a clinician manual, assessment and decision‐making tools, and a menu of cognitive health service options. Assessment uses the WRAT5‐Reading subtest and a new Self‐Assessment of Cognitive Functioning which, together, determine participant‐ and clinician‐perceived cognitive health need. Program‐level data were analysed for rates of assessment, identification of cognitive health needs and cognitive health service provision.ResultsData from 18 OnTrackNY teams included 933 participants, including 310 new admissions. Across teams, 43.9% of newly admitted participants received a WRAT5‐Reading and 41.3% received a self‐assessment. Of all assessments completed in the study period, 50.7% were at or within 3‐months of admission and 69.1% were within the first year of program participation. Cognitive health need was identified by self‐report (57.6%) and clinician‐report (69.9%) and led to provision of specific services, including psychoeducation, compensatory skills training and in some cases restorative cognitive training.ConclusionsPreliminary feasibility data are encouraging but barriers to assessment need to be identified and addressed. Rates of identified cognitive health need warrant further study of the implementation process and outcomes so that cognitive health assessment and treatment practices may ultimately be disseminated to CSC programs more broadly.
Impact of root canal treatment on high‐sensitivity C‐reactive protein levels in systemically healthy adults with apical periodontitis – a preliminary prospective, longitudinal interventional study
Authors: Poornima L. , Ravishankar P. , Abbott P. V. , Subbiya A. , PradeepKumar A. R. 
Published: November 2020

AbstractAimTo assess the influence of root canal treatment on serum high‐sensitivity C‐reactive protein (hsCRP) levels in systemically healthy human adults.MethodologyFifteen individuals aged 20–40 years diagnosed with apical periodontitis [Periapical Index (PAI) score ≥3] who were otherwise healthy took part in this prospective interventional study. Patients with moderate to severe periodontitis, systemic diseases and traditional cardiac risk factors (hypertension, diabetes, dyslipidemia and smoking) were excluded. Root canal treatment was completed in two visits with an inter‐appointment calcium hydroxide intracanal medicament. After 6 months, healing of apical periodontitis was evaluated clinically and radiographically, and serum hsCRP levels were recorded. A paired sample T‐test was used to compare the mean hsCRP values between the pre‐ and post‐treatment groups. The Mann–Whitney U test was used to compare hsCRP values between patients with PAI scores of 3 and 4, and the Wilcoxon signed‐rank test was used to compare pre‐ and postoperative PAI scores.ResultsThe mean preoperative baseline serum hsCRP level was 2.88 ± 1.06 mg L−1 which can be associated with a moderate risk for cardiovascular disease (CVD). Based on the preoperative hsCRP levels, eight of the 15 patients were categorized as high risk (hsCRP > 3 mg L−1) and the other seven as medium risk (hsCRP 1–3 mg L−1) for CVD. The mean preoperative hsCRP value of patients with a PAI score of 3 was 2.88 ± 1.19 mg L−1, and the mean preoperative hsCRP of patients with a PAI score of 4 was 2.87 ± 0.15 mg L−1, which was not significantly different (P = 0.942). Six months after root canal treatment, the mean PAI score had significantly reduced from 3.2 ± 0.42 to 1.4 ± 0.69 (P = 0.003). The PAI score had reduced to ≤2 in 87% of the patients, and the mean serum hsCRP levels had significantly reduced to 1.34 ± 0.52 mg L−1 (P < 0.001). Ten of the 15 patients had a reduction in their CVD risk status.ConclusionsThis study suggests that root canal treatment can reduce serum hsCRP levels in systemically healthy individuals with apical periodontitis.
Effect of poling on piezocatalytic removal of muti‐pollutants using BaTiO3
Authors: Xu Jin , Zang Tingting , Du Ding , Kumar Sandeep , Sharma Moolchand , Vaish Rahul 
Published: November 2020

AbstractThe BaTiO3 powder was prepared via a solid‐state reaction route. It was studied for the degradation of bacterial cells, dye, and pharmaceuticals waste using ultrasonically driven piezocatalytic effect. The bacterial catalytic behavior of poled BaTiO3 was remarkably increased during ultrasonication (10% E coli survival in 60 minutes). The structural damages were illustrated using scanning electron micrographs of bacterial cells which demonstrated morphological manifestations under different conditions. Methylene blue (MB dye), ciprofloxacin and diclofenac were also cleaned using the piezocatalytic effect associated with the poled BaTiO3 powder. Around 92, 85, and 78% of degradations were observed within 150 minutes duration for methylene blue, ciprofloxacin, and diclofenac, respectively.
Racial/Ethnic Differences in Health‐Related Quality of Life in Persons With and Without Dementia
Authors: Hayes‐Larson Eleanor , Mobley Taylor M. , Gilmore‐Bykovskyi Andrea , Shaw Crystal , Karlamangla Arun , Manly Jennifer J. , Mayeda Elizabeth Rose 
Published: November 2020

Background/ObjectivesGiven the lack of effective pharmacologic strategies to prevent, slow, or reverse dementia progression, maximizing quality of life (QOL) is a major priority for persons living with dementia. Despite well‐documented racial/ethnic disparities in dementia incidence and prevalence, it is unknown whether there are racial/ethnic disparities in QOL among persons with dementia. The objective of this study was to determine if there are racial/ethnic differences in poor health‐related quality of life (HRQOL) among persons with and without dementia in a nationally‐representative cohort.DesignRepeated measures cross‐sectional analysis of a prospective cohort study.SettingUnited States nationally‐representative National Health and Aging Trends Study (2011–2018).ParticipantsNon‐nursing home‐dwelling Black, Latino, and white adults age 65+ (n = 10,886).MeasurementsWe estimated racial/ethnic differences in five dichotomous indicators of poor HRQOL (depressive and anxiety symptoms, self‐rated health, pain, and physical functional limitations), stratified by dementia status (probable, possible, none). We used generalized estimating equations to estimate prevalence ratios (PRs) and differences, and marginal standardization to estimate prevalence.ResultsGenerally, Blacks and Latinos reported higher prevalence of poor HRQOL compared with whites. The largest differences were observed for self‐rated health, and Latino‐white differences were slightly larger compared to Black‐white differences. PRs were larger among those with no dementia. For example, the Black versus white PRs for poor self‐rated health were 1.93 (95% confidence interval (CI) = 1.82–2.04) among the no dementia group and 1.21 (95% CI = 1.12–1.31) among the probable dementia group; Latino versus white PRs for these comparisons were 2.39 (2.21–2.59) and 1.48 (1.35–1.62), respectively. Prevalence differences also showed racial/ethnic differences, but these were similar across dementia statuses.ConclusionsWe observed racial/ethnic disparities in poor HRQOL, showing greater unmet clinical needs among Black and Latino versus white older adults. Relative disparities were smaller in those with dementia, but absolute magnitudes of disparities were similar by dementia status.
Anonymous Trading in Equities
Authors: MELING TOM GRIMSTVEDT 
Published: November 2020

ABSTRACTIn this paper, I explore a reform at the Oslo Stock Exchange to assess the causal effect of posttrade trader anonymity on stock liquidity and trading volume. Using a regression discontinuity approach, I find that anonymity leads to a reduction in bid‐ask spreads of 40% and an increase in trading volume of more than 50%. The increase in trading volume is accounted for largely by increased trading activity by institutional investors, while retail investors do not adjust their trading behavior in response to anonymity. The results suggest that posttrade anonymity positively affects standard measures of market quality.
Sialolipomas of minor salivary glands: A multi‐institutional study and literature review
Authors: Cunha John Lennon Silva , de Sousa Sílvia Ferreira , Mota Carolina Peres , Rocha Silva João Vitor , Cavalcante Israel Leal , Marinho Erasmo Bernardo , Soares Ciro Dantas , de Albuquerque‐Júnior Ricardo Luiz Cavalcanti , Cavalcante Roberta Barroso , Abrahão Aline Corrêa , Agostini Michelle , Romañach Mario José , de Andrade Bruno Augusto Benevenuto , Vargas Pablo Agustin , de Almeida Oslei Paes 
Published: November 2020

AbstractBackgroundSialolipoma is a rare histological variant of lipoma commonly misdiagnosed and composed of a proliferation of mature adipocytes with secondary entrapment of normal salivary gland tissue. The purpose of the present study is to report the clinicopathologic and immunohistochemical features of 10 new cases of sialolipomas in conjunction with a review of the literature.MethodsA retrospective descriptive cross‐sectional study was performed. A total of 54,190 biopsy records of oral and maxillofacial lesions from four oral and maxillofacial pathology services in Brazil were analysed. All cases of lipomas were reviewed, and clinical, demographic and histopathological data were collected of all cases compatible with sialolipomas. In addition, immunohistochemistry stains (AE1/AE3, CK7, 34βE12, S‐100, HHF35, α‐SMA and Ki‐67) and a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus) were performed.ResultsAmong all lipomas reviewed, there were 10 cases of sialolipomas. The series comprised of 7 females (70.0%) and 3 males (30.0%), with a mean age of 46.1 ± 21.5 years (range: 11‐71 years) and a 2.3:1 female‐to‐male ratio. The lower lip (n = 3, 30.0%) and tongue (n = 2, 20.0%) were the most common locations, presenting clinically as a nodule of slow growth and normal colour. Conservative surgical excision was the treatment in all cases. No recurrence was observed.ConclusionSialolipomas are a rare histological variant of lipoma, affecting the salivary glands, mainly in the parotid gland and palate of female adults. Pathologists must recognise sialolipomas to avoid misdiagnoses with other lipomatous tumours that can affect salivary glands.
Overexpression of membranal SLC3A2 regulates the proliferation of oral squamous cancer cells and affects the prognosis of oral cancer patients
Authors: Liang Jiayu , Sun Zhida 
Published: November 2020

AbstractObjectiveOral squamous cell carcinoma (OSCC) is the most common cancer in oral and maxillofacial tissue. This study aimed to investigate the expression of SLC3A2 in human OSCC tissues and its regulatory roles in OSCC.MethodsThe expression of SLC3A2 in human OSCC tissues was assessed using immunohistochemistry. The proliferation, migration, and invasion of oral squamous cells were evaluated after knockdown of SLC3A2.ResultsThe expression of SLC3A2 in OSCC was higher than that in normal oral epithelial cells. SLC3A2 had higher expression levels in OSCC tissues than that in adjacent normal tissues. Upregulation of SLC3A2 was associated with advanced stages and poor survival of OSCC patients. In vitro experiments showed that knocking down of SLC3A2 was associated with reduced migration, invasion, and proliferation, but increased apoptosis of OSCC cells.ConclusionSLC3A2 exerted a harmful effect on OSCC patients by increasing migration, invasion and proliferation, and decreasing apoptosis.
A Mixed Methods Pilot Study of an Equity‐Explicit Student‐Teacher Relationship Intervention for the Ninth‐Grade Transition
Authors: Gaias Larissa M. , Cook Clayton R. , Nguyen Lillian , Brewer Stephanie K. , Brown Eric C. , Kiche Sharon , Shi Jiajing , Buntain‐Ricklefs Jodie , Duong Mylien T. 
Published: November 2020

ABSTRACTBACKGROUNDStudent‐teacher relationships are associated with the social and emotional climate of a school, a key domain of the Whole School, Whole Community, Whole Child Model. Few interventions target student‐teacher relationships during the critical transition to high school, or incorporate strategies for enhancing equitable relationships. We conducted a mixed‐methods feasibility study of a student‐teacher relationship intervention, called Equity‐Explicit Establish‐Maintain‐Restore (E‐EMR).METHODSWe tested whether students (N = 133) whose teachers received E‐EMR training demonstrated improved relationship quality, school belonging, motivation, behavior, and academic outcomes from pre‐ to post‐test, and whether these differences were moderated by race. We also examined how teachers (N = 16) integrated a focus on equity into their implementation of the intervention.RESULTSRelative to white students, students of the color showed greater improvement on belongingness, behavior, motivation, and GPA. Teachers described how they incorporated a focus on race/ethnicity, culture, and bias into E‐EMR practices, and situated their relationships with students within the contexts of their own identity, the classroom/school context, and broader systems of power and privilege.CONCLUSIONSWe provide preliminary evidence for E‐EMR to change teacher practice and reduce educational disparities for students of color. We discuss implications for other school‐based interventions to integrate an equity‐explicit focus into program content and evaluation.
Becoming Institutionalized: Incarceration as a Chronic Health Condition
Authors: Crane Johanna T. , Pascoe Kelsey 
Published: November 2020

AbstractThis article examines incarceration as a chronic condition with social, biological, and psychological elements. We do so through the lens of “institutionalization,” a concept that emerged during interviews conducted with 26 people incarcerated in Washington state prisons as a chronic and often disabling state resulting from prolonged incarceration. We argue that institutionalization helps conceptualize how the social inequities of mass incarceration become embodied as health inequities, and how social harms become physical harms. [prison, incarceration, institutionalization, chronic, inequality]