bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced pneumatic compression for treatment of lymphedema of the head and neck: a randomized wait-list controlled trial
Authors: Ridner Sheila H. , Dietrich Mary S. , Deng Jie , Ettema Sandra L. , Murphy Barbara 
Published: June 2020

Abstract
Purpose
Lymphedema associated with head and neck cancer (HNC) therapy causes adverse clinical outcomes. Standard treatment includes professionally administered complete decongestive therapy (CDT). Cost and availability of trained therapists are known barriers to therapy. Advanced pneumatic compression devices (APCD) may address these issues. A randomized, wait-list controlled trial was undertaken to evaluate an APCD in post-treatment HNC patients with lymphedema.

Material and methods
Eligible patients had completed treatment for HNC, were disease free, and had lymphedema at enrollment. Participants were randomized to wait-list lymphedema self-management (standard of care) or lymphedema self-management plus the use of the APCD bid. Safety (CTCAE V4.0) and feasibility were primary endpoints; secondary endpoints included efficacy measure by objective examination and patient reported outcomes (symptoms, quality of life, function), adherence barriers, and satisfaction. Assessments were conducted at baseline and weeks 4 and 8.

Results
Forty-nine patients were enrolled (wait-list n = 25; intervention n = 24). In total, forty-three patients completed the study. No device-related Serious Adverse Events were reported. Most patients used the APCD once per day, instead of the prescribed twice per day, citing time related factors as barriers to use. APCD use was associated with significant improvement in perceived ability to control lymphedema (p = 0.003) and visible external swelling (front view p < 0.001, right view p = 0.004, left p = 0.005), as well as less reported pain.

Conclusion
This trial supports the safety and feasibility of the APCD for the treatment of secondary lymphedema in head and neck cancer patients. In addition, preliminary data supports efficacy.
RS-HeRR: a rough set-based Hebbian rule reduction neuro-fuzzy system
Authors: Liu Feng , Sekh Arif Ahmed , Quek Chai , Ng Geok See , Prasad Dilip K. 
Published: June 2020

AbstractInterpretabilty is one of the desired characteristics in various classification task. Rule-based system and fuzzy logic can be used for interpretation in classification. The main drawback of rule-based system is that it may contain large complex rules for classification and sometimes it becomes very difficult in interpretation. Rule reduction is also difficult for various reasons. Removing important rules may effect in classification accuracy. This paper proposes a hybrid fuzzy-rough set approach named RS-HeRR for the generation of effective, interpretable and compact rule set. It combines a powerful rule generation and reduction fuzzy system, called Hebbian-based rule reduction algorithm (HeRR) and a novel rough-set-based attribute selection algorithm for rule reduction. The proposed hybridization leverages upon rule reduction through reduction in partial dependency as well as improvement in system performance to significantly reduce the problem of redundancy in HeRR, even while providing similar or better accuracy. RS-HeRR demonstrates these characteristics repeatedly over four diverse practical classification problems, such as diabetes identification, urban water treatment monitoring, sonar target classification, and detection of ovarian cancer. It also demonstrates excellent performance for highly biased datasets. In addition, it competes very well with established non-fuzzy classifiers and outperforms state-of-the-art methods that use rough sets for rule reduction in fuzzy systems.
Voltammetric sensing of recombinant viral dengue virus 2 NS1 based on Au nanoparticle–decorated multiwalled carbon nanotube composites
Authors: Palomar Quentin , Xu XingXing , Gondran Chantal , Holzinger Michael , Cosnier Serge , Zhang Zhen 
Published: June 2020

AbstractA homemade gold electrode is modified with a carbon nanotubes/gold nanoparticles nanocomposite to perform selective and sensitive electrochemical detection of dengue toxin. This nanostructured composite offers a large specific surface and a reactive interface allowing the immobilization of biological material. Dengue antibodies are immobilized on gold nanoparticles via covalent bonding for dengue toxin detection. The porous tridimensional network of carbon nanotubes and gold nanoparticles enhances the electrochemical signal and the overall performance of the sensor. After optimization, the system exhibits a high sensitivity of − 0.44 ± 0.01 μA per decade with wide linear range between 1 × 10−12 and 1 × 10−6 g/mL at a working potential of 0.22 V vs Ag/AgCl. The extremely low detection limit (3 × 10−13 g/mL) ranks this immunosensor as one of the most efficient reported in the literature for the detection of recombinant viral dengue virus 2 NS1. This biosensor also offers good selectivity, characterized by a low response to various non-specific targets and assays in human serum. The outstanding performances and the reproducibility of the system place the biosensor developed among the best candidates for future medical applications and for early diagnosis of dengue fever.
A note on computational approaches for the antibandwidth problem
Authors: Sinnl Markus 
Published: June 2020

AbstractIn this note, we consider the antibandwidth problem, also known as dual bandwidth problem, separation problem and maximum differential coloring problem. Given a labeled graph (i.e., a numbering of the vertices of a graph), the antibandwidth of a node is defined as the minimum absolute difference of its labeling to the labeling of all its adjacent vertices. The goal in the antibandwidth problem is to find a labeling maximizing the antibandwidth. The problem is NP-hard in general graphs and has applications in diverse areas like scheduling, radio frequency assignment, obnoxious facility location and map-coloring. There has been much work on deriving theoretical bounds for the problem and also in the design of metaheuristics in recent years. However, the optimality gaps between the best known solution values and reported upper bounds for the HarwellBoeing Matrix-instances, which are the commonly used benchmark instances for this problem, are often very large (e.g., up to 577%). Moreover, only for three of these 24 instances, the optimal solution is known, leading the authors of a state-of-the-art heuristic to conclude “HarwellBoeing instances are actually a challenge for modern heuristic methods”. The upper bounds reported in literature are based on the theoretical bounds involving simple graph characteristics, i.e., size, order and degree, and a mixed-integer programming (MIP) model. We present new MIP models for the problem, together with valid inequalities, and design a branch-and-cut algorithm and an iterative solution algorithm based on them. These algorithms also include two starting heuristics and a primal heuristic. We also present a constraint programming approach, and calculate upper bounds based on the stability number and chromatic number. Our computational study shows that the developed approaches allow to find the proven optimal solution for eight instances from literature, where the optimal solution was unknown and also provide reduced gaps for eleven additional instances, including improved solution values for seven instances, the largest optimality gap is now 46%.
Mediterranean wetland conservation in the context of climate and land cover change
Authors: Leberger Roxanne , Geijzendorffer Ilse R. , Gaget Elie , Gwelmami Anis , Galewski Thomas , Pereira Henrique M. , Guerra Carlos A. 
Published: June 2020

AbstractWetlands are known to support diverse and unique species assemblages. Globally, but particularly in the Mediterranean basin, they are threatened by climate change and natural habitat loss. Despite an alarming decline of wetlands over the last century, standardised and systematic site assessments at large scale do not exist. Here, we perform an integrated assessment of Mediterranean wetlands by evaluating the combination of wetland protection and anthropogenic pressures, namely climate and land cover change, and the subsequent impact on wintering waterbirds. We used a multivariate partial triadic analysis to quantify climate and land cover change for each site between 1990 and 2005. We found that wetland sites in the southeast of the Mediterranean basin combined low or no protection cover with the highest increases in temperature and losses in natural habitats. Despite these findings, these sites also lack observation data on biodiversity, which may underestimate the resulting impacts. However, there are examples where active conservation measurements contributed positively to slow down wetlands’ reduction. Biodiversity data coverage needs to be ensured, regularly updated, and extended across sites regardless of their protection level, to allow for the assessment of biodiversity trends. This should be further extended to include current investments in remote sensing approaches.
Balanced metrics and Berezin quantization on Hartogs triangles
Authors: Bi Enchao , Su Guicong 
Published: June 2020

AbstractIn this paper, we study balanced metrics and Berezin quantization on a class of Hartogs domains defined by $$\varOmega _n=\{(z_1,\ldots ,z_n)\in {\mathbb {C}}^n:\vert z_1\vert<\vert z_2\vert<\cdots<\vert z_n\vert <1\}$$

Ω
n

=
{

(

z
1

,
…
,

z
n

)

∈

C

n

:
|

z
1

|
<
|

z
2

|
<
⋯
<
|

z
n

|
<
1
}

which generalize the so-called classical Hartogs triangle. We introduce a Kähler metric $$g(\nu )$$

g
(
ν
)

associated with the Kähler potential $$\varPhi _n(z):=-\sum _{k=1}^{n-1}\nu _k\ln (\vert z_{k+1}\vert ^2-\vert z_k\vert ^2)-\nu _n\ln (1-\vert z_n\vert ^2)$$

Φ
n

(
z
)

:
=
-

∑

k
=
1

n
-
1

ν
k

ln
(
|

z

k
+
1

|

2

-
|

z
k

|

2

)
-

ν
n

ln
(
1
-
|

z
n

|
2

)

on $$\varOmega _n$$

Ω
n

. As main contributions, on one hand we compute the explicit form for Bergman kernel of weighted Hilbert space, and then, we obtain the necessary and sufficient condition for the metric $$g(\nu )$$

g
(
ν
)

on the domain $$\varOmega _n$$

Ω
n

to be a balanced metric. On the other hand, by using the Calabi’s diastasis function, we prove that the Hartogs triangles admit a Berezin quantization.
Breeding productivity, nest-site selection and conservation needs of the endemic Turkestan Ground-jay Podoces panderi
Authors: Burnside Robert J. , Brighten Alex L. , Collar Nigel J. , Soldatov Valentin , Koshkin Maxim , Dolman Paul M. , Ten Anna 
Published: June 2020

AbstractThe Turkestan Ground-jay Podoces panderi, a corvid endemic to the deserts of Central Asia, is both understudied and under-protected. Using standardised nest-monitoring protocols and nest cameras, we estimated its breeding productivity for the first time as 0.586 fledglings per nesting attempt (inter-quartile range, IQR 0.413‒0.734), strongly constrained by a diverse set of predator species (accounting for 88% of failures), supporting the broad pattern that a wide spectrum of nest predators operate in arid environments. The probability of nest success for the 35 days from the start of incubation to fledging was low, 0.186 $$\pm$$
±
0.06 se (N = 37), with no influence of season date, nest height or nest shrub species. However, pervasive shrub harvest severely limited availability of taller shrubs for nest-site selection, and thus our ability to detect any effect of height on nest survival. Mean clutch size was 4.8 $$\pm$$
±
0.8 sd while hatching probability of an egg from a clutch surviving incubation was 0.800 $$\pm$$
±
0.050 se and fledging probability was 0.824 $$\pm$$
±
0.093 se for individual chicks in successful nests (i.e. that fledged one or more chicks). Two shrub genera, saxaul Haloxylon spp. and Calligonum spp., were used for nesting more frequently than expected ($${\chi }_{15}^{2}$$

χ

15

2

= 784.02, P < 0.001), highlighting their importance to breeding habitat suitability. This near-sole reliance on these taller shrub genera, both targeted for illegal cutting, indicates that habitat degradation may lead to increased predation and declines in productivity. Habitat conservation is, therefore, likely to be the most important management strategy for the species and other components of desert systems, as management of so diverse a set of nest predators would be both impractical and inappropriate.
On the landslide tsunami uncertainty and hazard
Authors: Løvholt Finn , Glimsdal Sylfest , Harbitz Carl B. 
Published: June 2020

AbstractLandslides are the second most frequent tsunami source worldwide. However, their complex and diverse nature of origin combined with their infrequent event records make prognostic modelling challenging. In this paper, we present a probabilistic framework for analysing uncertainties emerging from the landslide source process. This probabilistic framework employs event trees and is used to conduct tsunami uncertainty analysis as well as probabilistic tsunami hazard analysis (PTHA). An example study is presented for the Lyngen fjord in Norway. This application uses a mix of empirical landslide data combined with expert judgement to come up with probability maps for tsunami inundation. Based on this study, it is concluded that the present landslide tsunami hazard analysis is largely driven by epistemic uncertainties. These epistemic uncertainties can be incorporated in the probabilistic framework. Conducting a literature analysis, we further show examples of how landslide and tsunami data can be used to better constrain landslide uncertainties, combined with statistical and numerical analysis methods. We discuss how these methods, combined with the probabilistic framework, can be used to improve landslide tsunami hazard analysis in the future.
Trade and economic development: global causality and development- and openness-related heterogeneity
Authors: Gries T. , Redlin M. 
Published: June 2020

Abstract
This paper reconsiders the classic relationship between trade and economic development. We examine the short-term and long-run dynamics between trade and income for 167 countries over the period 1970–2011 and assume that the effect is not homogenous for all countries but rather varies according to the development stage and the degree of trade openness. We apply panel cointegration, Granger causality and panel error correction in combination with Dynamic Ordinary Least Squares and General Method of Moments estimation to explore the causal relationship between these two variables. The results suggest a statistically significant positive short-run and long-run global relationship between trade and income. However, when splitting the panel into different income and trade openness groups, a long-run relationship is observed only for high-income countries and countries with a relatively high degree of trade openness.
Cultural Group Selection and the Evolution of Reindeer Herding in Norway
Authors: Næss Marius Warg 
Published: June 2020

AbstractHerding can be characterized as a coordination game with two strategies for minimising risk: increase herd size (livestock quantity) or increase livestock body mass (livestock quality). In this paper I demonstrate that the selection of herd maximisation as a risk management strategy in the Northern parts of Norway has been influenced by a history of intra-group competition exacerbating herder conflict and lack of trust. In the South herder-farmer conflicts have increased herder coordination and trust, resulting in the selection of increasing livestock quality as the dominant risk management strategy.
Comparison of visual outcomes after implantation of AtLisa tri 839 MP and Symfony intraocular lenses
Authors: Lubiński Wojciech , Podborączyńska-Jodko Karolina , Kirkiewicz Marta , Mularczyk Maciej , Post Michał 
Published: June 2020

Abstract
Purpose
To compare visual outcomes after implantation of AtLisa tri 839 MP and Symfony intraocular lenses (IOLs).

Methods
All subjects underwent sequential bilateral cataract extraction with AtLisa tri 839 MP or Symfony IOL implantation. The design is prospective case series. Each group consists of 20 patients (40 eyes). At 1 year postoperatively, the following parameters were analysed: binocular uncorrected visual acuity (log MAR): for distance (UDVA) at 4 m, for intermediate distances (UIVA) at 60, 70, 80 cm and for near (UNVA) at 40 cm, defocus curve, mesopic and photopic contrast sensitivities (CSs), spectacle independence, visual function test questionnaire modified VFQ-25), photopic phenomena and postoperative complications.

Results
In the AtLisa tri 839 MP group, the mean binocular UNVA and UIVA were significantly better than in the Symfony group (UNVA: − 0.01 ± 0.04 vs. 0.21 ± 0.15; p = 0.000; 60 cm UIVA: − 0.01 ± 0.04 vs. 0.09 ± 0.09, p = 0.001; 70 cm UIVA − 0.05 ± 0.06 vs. 0.11 ± 0.08, p = 0.002; 80 cm UIVA − 0.01 ± 0.06 vs. 0.15 ± 0.08, p = 0.019). There were no significant between-group differences in the mean binocular UDVA and CS, with one exception: the mean binocular distance CS (18 cpd) under mesopic conditions was significantly better in the Symfony group than in the AtLisa tri 839 MP group (1.39 ± 0.22 vs. 1.17 ± 0.27; p = 0.015). The defocus curve analysis revealed significant between-group differences at vergences of 2.0 to − 4.0 D (p < 0.05), except for 2.0, 1.0, 0 and − 1.5. All subjects in AtLisa tri 839 MP group and 18 subjects (90%) in Symfony group were spectacle independent. Patients from both groups highly rated their overall vision quality in the VFQ-25 (1.67 ± 0.47 vs. 1.85 ± 0.5 in the Symfony and AtLisa tri 839 MP group, respectively, p = NS). The scores for daytime driving (1.00 ± 0.00 vs. 1.21 ± 0.36; p = 0.002), night driving (1.57 ± 0.55 vs. 2.13 ± 1.15; p = 0.027) and difficult situation driving (1.14 ± 0.31 vs. 1.53 ± 0.56; p = 0.049) were significantly better in the AtLisa tri 839 MP group than in the Symfony group. The incidence and perception level of halo and glare were significantly reduced (p = 0.00) in the Symfony group as compared to the AtLisa tri 839 MP group. The postoperative course was uneventful in all subjects.

Conclusions
Visual outcomes achieved with both IOLs are comparable. In both groups, 90% of patients achieved spectacle independence. Whereas the AtLisa tri 839 MP IOL implantation was associated with slightly better intermediate distance VA and significantly better near VA, photic phenomena were less perceived by patients with Symfony IOLs.
Post-buckling of web-core sandwich plates based on classical continuum mechanics: success and needs for non-classical formulations
Authors: Romanoff Jani , Jelovica Jasmin , Reddy J. N. , Remes Heikki 
Published: June 2020

AbstractThe paper investigates the post-buckling response of web-core sandwich plates through classical continuum mechanics assumptions. The compressive loading is assumed to be in the direction of the web plates. Equivalent Single Layer (ESL) plate formulation is used with the kinematics of the First order Shear Deformation Theory (FSDT). During the initial, membrane-dominated loading stages, it is observed that the effect of finite size of the periodic microstructure is barely influences the plate responses. At the higher loads, when bending is activated, the finite size of the microstructure activates secondary shear-induced bending moments at the unit cells of the plate. A method to capture the envelope of the maximum values of these bending moments is presented. The findings are validated with the shell element models of the actual 3D-geometry. Finally, the physical limits of the classical continuum mechanics are discussed in the present context.
A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization
Authors: Khan Iftikhar , Lau Katie , Bnyan Ruba , Houacine Chahinez , Roberts Matthew , Isreb Abdullah , Elhissi Abdelbary , Yousaf Sakib 
Published: June 2020

Abstract
Purpose
The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery.

Method
Proliposome powder formulations (i.e. F1 – F27) were prepared employing Lactose monohydrate (LMH), Microcrystalline cellulose (MCC) or Starch as a carbohydrate carriers and Soya phosphatidylcholine (SPC), Hydrogenated soya phosphatidylcholine (HSPC) or Dimyristoly phosphatidylcholine (DMPC) as a phospholipid. Proliposome powder formulations were prepared in 1:5, 1:15 or 1:25 w/w lipid phase to carrier ratio (lipid phase; comprising of phospholipid and cholesterol in 1:1 M ratio) and Paclitaxel (PTX) was used as model anticancer drug.

Results
Based on flowability studies, out of 27 formulations; F3, F6, and F9 formulations were selected as they exhibited an excellent angle of repose (AOR) (17.24 ± 0.43, 16.41 ± 0.52 and 15.16 ± 0.72°), comparatively lower size of vesicles (i.e. 5.35 ± 0.76, 6.27 ± 0.59 and 5.43 ± 0.68 μm) and good compressibility index (14.81 ± 0.36, 15.01 ± 0.35 and 14.56 ± 0.14) via Carr’s index. The selected formulations were reduced into Nano (N) vesicles via probe sonication, followed by spray drying (SD) to get a dry powder of these formulations as F3SDN, F6SDN and F9SDN, and gave high yield (>53%) and exhibited poor to very poor compressibility index values via Carr’s Index. Post tablet manufacturing, F3 tablets formulation showed uniform weight uniformity (129.40 ± 3.85 mg), good crushing strength (14.08 ± 1.95 N), precise tablet thickness (2.33 ± 0.51 mm) and a short disintegration time of 14.35 ± 0.56 min, passing all quality control tests in accordance with British Pharmacopeia (BP). Upon nebulization of F3 tablets formulation, Ultrasonic nebulizer showed better nebulization time (8.75 ± 0.86 min) and high output rate (421.06 ± 7.19 mg/min) when compared to Vibrating mesh nebulizer. PTX-loaded F3 tablet formulations were identified as toxic (60% cell viability) to cancer MRC-5 SV2 cell lines while safe to normal MRC-5 cell lines.

Conclusion
Overall, in this study LMH was identified as a superior carbohydrate carrier for proliposome tablet manufacturing in a 1:25 w/w lipid to carrier ratio for in-vitro nebulization via Ultrasonic nebulizer.