bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efforts to mitigate the economic impact of the COVID-19 pandemic: potential entry points for neglected tropical diseases
Authors: Ehrenberg John P. , Utzinger Jürg , Fontes Gilberto , da Rocha Eliana Maria Mauricio , Ehrenberg Nieves , Zhou Xiao-Nong , Steinmann Peter 
Published: January 2021

Abstract
Background
The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted and economic growth has already evaporated, giving rise to a global recession, the likes of which we may not have experienced since the Second World War. Our aim is to draw the attention of the neglected tropical disease (NTD) community towards some of the major emerging economic opportunities which are quickly appearing on the horizon as a result of COVID-19.

Main text
This scoping review relied on a literature search comprised of a sample of articles, statements, and press releases on initiatives aimed at mitigating the impact of COVID-19, while supporting economic recovery. Of note, the donor scenario and economic development agendas are highly dynamic and expected to change rapidly as the COVID-19 pandemic unfolds, as are donor and lender priorities.

Conclusions
The NTD community, particularly in low- and middle-income countries (LMICs), will need to work quickly, diligently, and in close collaboration with decision-makers and key stakeholders, across sectors at national and international level to secure its position. Doing so might enhance the odds of grasping potential opportunities to access some of the massive resources that are now available in the form of contributions from corporate foundations, trust funds, loans, debt relieve schemes, and other financial mechanisms, as part of the ongoing and future economic development agendas and public health priorities driven by the COVID-19 pandemic. This paper should serve as a starting point for the NTD community to seek much needed financial support in order to sustain and revitalize control and elimination efforts pertaining to NTDs in LMICs.
What factors are most important for the development of the maternal–fetal relationship? A prospective study among pregnant women in Danish general practice
Authors: Ertmann Ruth K. , Bang Christine W. , Kriegbaum Margit , Væver Mette S. , Kragstrup Jakob , Siersma Volkert , Wilson Philip , Lutterodt Melissa C. , Smith-Nielsen Johanne 
Published: January 2021

Abstract
Background
Development of the maternal antenatal attachment (MAA) constitutes an important aspect of the transition into motherhood. Early identification of women at risk of developing a poor MAA provides possibilities for preventive interventions targeting maternal mental health and the emerging mother-infant relationship. In this study, we investigate the relative importance of an extensive set of psychosocial, pregnancy-related, and physiological factors measured in the first trimester of pregnancy for MAA measured in third trimester.

Methods
A prospective study was conducted among pregnant women in Danish general practice (GP). Data were obtained in the first and the third trimester from pregnancy health records and electronic questionnaires associated with routine GP antenatal care visits. The Maternal Antenatal Attachment Scale (MAAS) was used to assess maternal antenatal attachment. The relative importance of potential determinants of maternal antenatal attachment was assessed by the relative contribution of each factor to the fit (R2) calculated from multivariable regression models.

Results
The sample consisted of 1328 women. Low antenatal attachment (Total MAAS ≤ 75) was observed for 513 (38.6%) women. Perceived social support (having someone to talk to and having access to practical help when needed) emerged as the most important determinant. Furthermore, scores on the MAAS decreased with worse self-rated health, poor physical fitness, depression, increasing age, having given birth previously, and higher education.

Conclusion
Pregnant women reporting lack of social support and general low physical and mental well-being early in pregnancy may be at risk for developing a poor MAA. An approach targeting both psychosocial and physiological well-being may positively influence expectant mothers’ successful adaptation to motherhood.
An eye-tracking study of interpersonal threat sensitivity and adverse childhood experiences in borderline personality disorder
Authors: Seitz Katja I. , Leitenstorfer Johanna , Krauch Marlene , Hillmann Karen , Boll Sabrina , Ueltzhoeffer Kai , Neukel Corinne , Kleindienst Nikolaus , Herpertz Sabine C. , Bertsch Katja 
Published: January 2021

Abstract
Background
Previous eye-tracking studies provide preliminary evidence for a hypersensitivity to negative, potentially threatening interpersonal cues in borderline personality disorder (BPD). From an etiological point of view, such interpersonal threat hypersensitivity might be explained by a biological vulnerability along with a history of early life adversities. The objective of the current study was to investigate interpersonal threat hypersensitivity and its association with adverse childhood experiences (ACE) in patients with BPD employing eye-tracking technology.

Methods
We examined a sample of 46 unmedicated, adult female patients with BPD and 25 healthy female volunteers, matched on age and intelligence, with a well-established emotion classification paradigm with angry, fearful, happy, and neutral facial expressions. ACE were assessed retrospectively with the Childhood Trauma Questionnaire.

Results
Patients as compared to healthy volunteers reflexively directed their gaze more quickly towards the eyes of emotional and neutral faces and did not adapt their fixation patterns according to the facial expression presented. Misclassifying emotional and neutral faces as angry correlated positively with the patients’ self-reported ACE.

Conclusions
Building on and extending earlier findings, our results are likely to suggest a visual hypervigilance towards the eyes of emotional and neutral facial expressions and a childhood trauma-related anger bias in patients with BPD. Given the lack of a clinical control group, the question whether these findings are specific for BPD has to remain open. Thus, further research is needed to elucidate the specificity of altered visual attention allocation and the role of ACE in anger recognition in patients with BPD.
Study on thickness-dependence characteristics of bismuth ferrite (BFO) for ultraviolet (UV) photodetector application
Authors: Kossar Shahnaz , Amiruddin R. , Rasool Asif 
Published: January 2021

AbstractThe present research work reports on the fabrication of ultraviolet (UV) photodetectors using bismuth ferrite (BiFeO3, BFO) thin films with varying thickness. Using the spray pyrolysis technique, BFO thin films were deposited on the glass substrate at 673 K. The deposited BFO thin films were characterized by Raman and FTIR spectroscopic analysis. The morphological analysis reveals uniform grain distribution for the prepared BFO samples. The optical analysis reveals that transmittance value decreases upon an increase in the thickness of BFO thin films and the calculated optical band gap value lies between 2.0 to 2.3 eV. The varying thickness of the BFO active layer was stacked between ITO and Al electrodes and the current–voltage (I–V) characteristics of the fabricated ITO/BFO/Al devices were studied under dark and UV illumination (λ = 365 nm). It was observed that BFO with an optimum thickness (365 nm) exhibits higher photoresponsivity of 110 mA/W with an external quantum efficiency (EQE) of 37.30%. The impact of different thickness of the BFO active layer, the role of adsorption and desorption of oxygen (O2) molecules upon the surface of BFO layers towards UV photoresponse characteristics were investigated.
Inappropriate antibiotic prescribing for acute bronchiolitis in Colombia: a predictive model
Authors: Buendía Jefferson Antonio , Feliciano-Alfonso John Edwin 
Published: January 2021

Abstract
Introduction
Acute bronchiolitis is the leading cause of hospitalization in the pediatric population. The inappropriate prescription of antibiotics in acute bronchiolitis is associated with bacterial resistance, higher costs, and risk of adverse effects in this population. The objective of this work is to develop a predictive model of inappropriate use of antibiotics in children with acute bronchiolitis in Colombia.

Methods
A retrospective cohort study was conducted in patients under 2 years of age with a diagnosis of acute bronchiolitis from two hospitals in Rionegro, Colombia. To identify factors independently associated with inappropriate use of antibiotics, we used logistic regression and estimated odds ratios (ORs). To assess discrimination, area under the curve (AUC) was estimated with a 95% confidence interval and plotted using AUC–ROC plots. To correct sampling bias of variance parameters and to evaluate the internal validity of the model, repeated curved validation “tenfold cross-validation” was used, comparing the area under the ROC curve obtained in the repetitions with that observed in the model

Results
A total of 415 patients were included. 142 patients (34.13%) had a prescription of some antibiotic during their hospital stay. In 92 patients (64.78%, 95% CI 56.3 to 72.6%) the prescription of antibiotics was classified as inappropriate. Age older than 1 year, chest retractions, temperature between 37.5 °C and 38.5 °C and leukocyte count between 10,000 and 15,000 million/mm3 were the predictive variables of inappropriate use of medications in this population.

Conclusion
The presence of fever between 37.5 °C and 38.5 °C, leukocytosis between 10,000 and 15,000 million/mm3, and age older than 1 year and presence of chest retractions, should alert the physician regarding the high risk of inappropriate prescription of antibiotics. Patients with acute bronchiolitis with a score on our scale greater than 2 should be carefully evaluated regarding the need for the use of antibiotics, if prescribed.
Magnetotelluric study in the Los Lagos Region (Chile) to investigate volcano-tectonic processes in the Southern Andes
Authors: Segovia Maria Jose , Diaz Daniel , Slezak Katarzyna , Zuñiga Felipe 
Published: January 2021

AbstractTo analyze the process of subduction of the Nazca and South American plates in the area of the Southern Andes, and its relationship with the tectonic and volcanic regime of the place, magnetotelluric measurements were made through a transversal profile of the Chilean continental margin. The data-processing stage included the analysis of dimensional parameters, which as first results showed a three-dimensional environment for periods less than 1 s and two-dimensional for periods greater than 10 s. In addition, through the geomagnetic transfer function (tipper), the presence of structural electrical anisotropy was identified in the data. After the dimensional analysis, a deep electrical resistivity image was obtained by inverting a 2D and a 3D model. Surface conductive anomalies were obtained beneath the central depression related to the early dehydration of the slab and the serpentinization process of the mantle that coincides in location with a discontinuity in the electrical resistivity of a regional body that we identified as the Nazca plate. A shallow conductive body was located around the Calbuco volcano and was correlated with a magmatic chamber or reservoir which in turn appears to be connected to the Liquiñe Ofqui fault system and the Andean Transverse Fault system. In addition to the serpentinization process, when the oceanic crust reaches a depth of 80–100 km, the ascending fluids produced by the dehydration and phase changes of the minerals present in the oceanic plate produce basaltic melts in the wedge of the subcontinental mantle that give rise to an eclogitization process and this explains a large conductivity anomaly present beneath the main mountain range.
Strength models of the terrestrial planets and implications for their lithospheric structure and evolution
Authors: Katayama Ikuo 
Published: January 2021

AbstractKnowledge of lithospheric strength can help to understand the internal structure and evolution of the terrestrial planets, as surface topography and gravity fields are controlled mainly by deformational features within the lithosphere. Here, strength profiles of lithosphere were calculated for each planet using a recently updated flow law and taking into account the effect of water on lithospheric deformation. Strength is controlled predominantly by brittle deformation at shallow depths, whereas plastic deformation becomes dominant at greater depths through its sensitivity to temperature. Incorporation of Peierls creep, in which strain rate is exponentially dependent on stress, results in the weakening of plastic strength at higher stress levels, and the transition from brittle to ductile deformation shifts to shallower depths than those calculated using conventional power-law creep. Strength in both the brittle and ductile regimes is highly sensitive to the presence of water, with the overall strength of the lithosphere decreasing markedly under wet conditions. The markedly low frictional coefficient of clay minerals results in a further decrease in brittle strength and is attributed to expansion of the brittle field. As plastic strength is influenced by lithology, a large strength contrast can occur across the crust–mantle boundary if deformation is controlled by ductile deformation. Effective elastic thickness for the terrestrial planets calculated from the rheological models indicates its close dependence on spatiotemporal variations in temperature and the presence of water. Although application of the strength models to observed large-scale surface deformational features is subject to large extrapolation and uncertainties, I emphasize the different sensitivity of these features to temperature and water, meaning that quantifying these features (e.g., by data from orbiting satellites or rovers) should help to constrain the internal structure and evolution of the terrestrial planets.
History matters: the long-term impact of historical immigrant size on current xenophobia in Japan
Authors: Gong Shun , Wang Senhu 
Published: January 2021

AbstractMany studies have addressed how current immigrant size affects the strength of xenophobia from the perspectives of intergroup contact and ethnic competition theories. Can native residents’ current xenophobia be explained by historical immigrant size? To explore this question, we use historical immigrant size and a survey dataset to investigate the long-term effects of historical immigrant size on current xenophobia in Japan. The results show that historical immigrant size increases current xenophobia in Japan, which may be due to previous negative contact experiences between immigrants and native residents, and the negative effects persist. The implications of these findings for our understanding of the relationship between immigrant size and xenophobia are discussed.
Fentanyl compared to buprenorphine for atrial fibrillation ablation analgesia and sedation: a retrospective cross-sectional study
Authors: Kinoshita Teruhisa , Harada Mitsunori , Takimoto Norio , Shibata Daichi , Sakakibara Takashi , Adachi Mamoru 
Published: January 2021

Abstract
Background
The effects of general anesthesia with deep sedation and conscious sedation have been compared for sedation management in the perioperative period for radiofrequency catheter ablation of the heart to treat atrial fibrillation. However, there is no consensus as to which drug to use for conscious sedation. This study aimed to investigate analgesic and sedative drugs suitable for perioperative ablation.

Methods
We retrospectively examined 93 patients who underwent atrial fibrillation ablation at Kariya Toyoda General Hospital between December 2017 and April 2019 and investigated differences in the outcomes, such as depth of sedation and postoperative adverse events between the buprenorphine hydrochloride (n = 46) and fentanyl citrate (n = 47) groups.

Results
The depth of sedation was similar between the two groups, without significant between-group differences in postoperative vomiting. The number of additional injections of thiamylal sodium to manage discomfort and pain during ablation were significantly lower in the fentanyl group. Additionally, the cumulative area product, cumulative total air kerma, 1-year postoperative atrial fibrillation recurrence rate, and postoperative complications were not significantly different between the two groups.

Conclusions
Although there were no significant differences in the efficacy or safety between buprenorphine hydrochloride and fentanyl citrate as analgesics used during atrial fibrillation ablation, intraoperative body movements and patient discomfort could be reduced to a greater extent with the use of fentanyl.
Development of an intervention to increase adherence to nebuliser treatment in adults with cystic fibrosis: CFHealthHub
Authors: Arden M. A. , Hutchings M. , Whelan P. , Drabble S. J. , Beever D. , Bradley J. M. , Hind D. , Ainsworth J. , Maguire C. , Cantrill H. , O’Cathain A. , Wildman M. 
Published: January 2021

Abstract
Background
Cystic fibrosis (CF) is a life-limiting genetic condition in which daily therapies to maintain lung health are critical, yet treatment adherence is low. Previous interventions to increase adherence have been largely unsuccessful and this is likely due to a lack of focus on behavioural evidence and theory alongside input from people with CF. This intervention is based on a digital platform that collects and displays objective nebuliser adherence data. The purpose of this paper is to identify the specific components of an intervention to increase and maintain adherence to nebuliser treatments in adults with CF with a focus on reducing effort and treatment burden.

Methods
Intervention development was informed by the Behaviour Change Wheel (BCW) and person-based approach (PBA). A multidisciplinary team conducted qualitative research to inform a needs analysis, selected, and refined intervention components and methods of delivery, mapped adherence-related barriers and facilitators, associated intervention functions and behaviour change techniques, and utilised iterative feedback to develop and refine content and processes.

Results
Results indicated that people with CF need to understand their treatment, be able to monitor adherence, have treatment goals and feedback and confidence in their ability to adhere, have a treatment plan to develop habits for treatment, and be able to solve problems around treatment adherence. Behaviour change techniques were selected to address each of these needs and were incorporated into the digital intervention developed iteratively, alongside a manual and training for health professionals. Feedback from people with CF and clinicians helped to refine the intervention which could be tailored to individual patient needs.

Conclusions
The intervention development process is underpinned by a strong theoretical framework and evidence base and was developed by a multidisciplinary team with a range of skills and expertise integrated with substantial input from patients and clinicians. This multifaceted development strategy has ensured that the intervention is usable and acceptable to people with CF and clinicians, providing the best chance of success in supporting people with CF with different needs to increase and maintain their adherence. The intervention is being tested in a randomised controlled trial across 19 UK sites.
Green bonds issuance: insights in low- and middle-income countries
Authors: Otek Ntsama Ursule Yvanna , Yan Chen , Nasiri Alireza , Mbouombouo Mboungam Abdel Hamid 
Published: January 2021

AbstractFormer reports of Environmental, Social and Governance (ESG) tended to focus on the equity side of investing, and today green bonds also offer and introduce sustainability factors. This paper is about the relevance, potential benefits and key arguments for countries with low-and middle-incomes where financial markets are not comparable with those in developed countries. We begin by stating clearly the relevance of a green economy transformation, highlight the development challenges they face and talk about how a green economy approach can help to solve these challenges. Then an outline of the progress that has been made in this panel, and the economic and social benefits that a green economy can potentially offer to Low- and Middle-Income countries (LMIC’s) will be underlined. Finally, we will make recommendations on the range of potential areas for intervention.
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis
Authors: Ge Yanzhi , Zhou Li , Chen Zuxiang , Mao Yingying , Li Ting , Tong Peijian , Shan Letian 
Published: January 2021

Abstract
Background
The disability rate associated with rheumatoid arthritis (RA) ranks high among inflammatory joint diseases. However, the cause and potential molecular events are as yet not clear. Here, we aimed to identify differentially expressed genes (DEGs), pathways and immune infiltration involved in RA utilizing integrated bioinformatics analysis and investigating potential molecular mechanisms.

Materials and methods
The expression profiles of GSE55235, GSE55457, GSE55584 and GSE77298 were downloaded from the Gene Expression Omnibus database, which contained 76 synovial membrane samples, including 49 RA samples and 27 normal controls. The microarray datasets were consolidated and DEGs were acquired and further analyzed by bioinformatics techniques. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DEGs were performed using R (version 3.6.1) software, respectively. The protein-protein interaction (PPI) network of DEGs were developed utilizing the STRING database. Finally, the CIBERSORT was used to evaluate the infiltration of immune cells in RA.

Results
A total of 828 DEGs were recognized, with 758 up-regulated and 70 down-regulated. GO and KEGG pathway analyses demonstrated that these DEGs focused primarily on cytokine receptor activity and relevant signaling pathways. The 30 most firmly related genes among DEGs were identified from the PPI network. The principal component analysis showed that there was a significant difference between the two tissues in infiltration immune.

Conclusion
This study shows that screening for DEGs, pathways and immune infiltration utilizing integrated bioinformatics analyses could aid in the comprehension of the molecular mechanisms involved in RA development. Besides, our study provides valuable data related to DEGs, pathways and immune infiltration of RA and may provide new insight into the understanding of molecular mechanisms.