bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legitimized identity vs identifiable legitimacy
Authors: Xiu Lin , Lu Feng , Liang Xin 
Published: November 2019

PurposeOrganizational identity and organizational legitimacy are related constructs, but comprehensive studies of the relationship have been lacking in the literature of organizational studies. This paper aims to propose a framework that includes four possible relationships between organizational legitimacy and identity.Design/methodology/approachThe authors evaluate the causes of each of these relationships and an important consequence of the relationship: their influences on organizational adaptation.FindingsWith a series of propositions, the authors make a tentative, but valuable, move toward integrating two broad streams of social perspective of organizing, institutional theory and organizational identity and call for research efforts in this direction.Originality/valueThe paper is the first one that explores the relationship between organizational identity and organizational legitimacy in a comprehensive way.
Crisis responses in public hospitals: case studies in Hong Kong
Authors: Wut Tai-ming 
Published: November 2019

Purpose
The purpose of this paper is to investigate the medical incident responses from two public hospitals in Hong Kong, namely, Kowloon Hospital and Caritas Medical Centre, in order to improve the strategic preparation for crisis management in hospitals.

Design/methodology/approach
The paper analyses two medical incidents using Situational Crisis Communication Theory by Coombs (2007). The two case studies presented herein demonstrate the importance of consistency in terms of crisis responses.

Findings
For the first case, the crisis responses from different parties after the incident, including Hospital Authority, the doctor and the nurses from Kowloon Hospital, are contradicting to each other. First, Hospital Authority confirmed that the incident is solely an accident which is a denial response. Second, the doctor passed the responsibility to the nurses which is a scapegoating response. Third, the nurses tend to reduce the responsibility for the death of patient by excusing strategy. As a whole, their responses are inconsistent to each other. For the second case, Caritas had initially denied the responsibilities, but finally had given partial apology under public pressure. That makes people think that Caritas does not really regret.

Originality/value
Rebuilding posture should be used instead of denial and diminishment posture. However, public organization and civil servants are reluctant to use a full apology due to possible legal consequences. The apology ordinance would ease the pressure to express regret and sympathy.
Omni-channel users and omni-channel customers: a segmentation analysis using distribution services
Authors: Cortiñas Monica , Chocarro Raquel , Elorz Margarita 
Published: November 2019

Purpose
Consumers are increasingly combining distribution channels, thus displaying so-called omni-channel behavior, both to complete a given purchase and between purchases. The authors make a distinction between omni-channel customers, who make use of distribution services in both channels and omni-channel users, who make partial use of the distribution services of one channel to support purchases in another. This paper aims to identify the omni-channel behavior among the customers of a global fast fashion retailer dealing in a wide range of apparel and clothing accessories.

Design/methodology/approach
Using a multinomial logit model, the authors perform a customer segmentation based on observed omni-channel behavior, considering the explanatory roles of demographics, distribution service features and customer service policies across the different retail channels.

Findings
The authors observe that the key retail channel features for explaining omni-channel customer behavior are product accessibility, both in store and online; the assurance that goods purchased online will satisfy the customer’s needs and expectations; and the option to return goods found unsatisfactory.

Practical implications
The results clearly show that the nature of the visits and purchases made by customers is determined by various components of the companýs customer service policy, which can, therefore, be used to guide the retailer’s segmentation strategy.

Originality/value
Future lines of research should explore the economic implications of this customer segmentation. The price perception data emerging from our findings suggest a greater sensitivity to prices in the mono-channel segment, which might be worth exploring in future research.

Future research
Future lines of research should explore the economic implications of this customer segmentation. The price perception data emerging from our findings suggest a greater sensitivity to prices in the mono-channel segment which might be worth exploring in future research.
Catechins and Caffeine Promote Lipid Metabolism and Heat Production Through the Transformation of Differentiated 3T3‐L1 Adipocytes from White to Beige Adipocytes
Authors: Sugiura Chikako , Zheng Guodong , Liu Litong , Sayama Kazutoshi 
Published: November 2019

AbstractTo elucidate effects of catechins and caffeine on lipid metabolism in adipocytes and identify the mechanism of action, differentiated 3T3‐L1 adipocytes were incubated in culture media containing catechins at 1, 2.5, 5, and 10 µg/mL and caffeine at 50 and 100 µg/mL, singly or in combination, for 8 days. Intracellular lipid accumulation and glycerol‐3‐phosphate dehydrogenase activity were strongly suppressed by catechins and caffeine combination treatment. The mRNA expression of PPARɤ, GLUT4, HSL, UCP‐1, and TMEM26 were significantly increased in the combined groups. These findings suggest that the combined treatment inhibited lipid synthesis and improved lipid metabolism in adipocytes. Moreover, it was indicated that the differentiated 3T3‐L1 adipocytes could be transformed from white adipocytes to beige‐like adipocytes by catechins and caffeine, and accordingly that this transformation could promote calorigenic action.Practical ApplicationIn this study, we revealed that the combined treatment of catechins and caffeine inhibited lipid synthesis and improved lipid metabolism in adipocytes. Moreover, the treatment may contribute to the transforming from white adipocytes to beige‐like adipocytes, which could strongly promote calorigenic action.
Branding Angelica: Reputation Management in Late Eighteenth‐Century England
Authors: Vickery Amanda 
Published: November 2019

AbstractReputation management is a contemporary offshoot of public relations, but reputation has long had economic currency in British culture. Less well studied is the way commercial reputation consolidated around ideas of the brand. This case study of the London career of the Swiss‐born artist Angelica Kauffman (1741‐1807) examines the development of the ‘Angelica' brand: from stage‐managed debut, studio establishment and performance, and self‐promotion through self‐portraiture to market positioning, diffusion lines and pricing strategy. It tests the success of Kauffman's efforts by examining critical reception, consumer response and, finally, damage limitation, concluding that the Angelica brand was the painter's cleverest creation.
Taiwan Rheumatology Association consensus recommendations for the management of axial spondyloarthritis
Authors: Wei James Cheng‐Chung , Liu Chin‐Hsiu , Tseng Jui‐Cheng , Hsieh Lin‐Fen , Chen Chun‐Hsiung , Chen Hsin‐Hua , Chen Hung‐An , Chen Ying‐Chou , Chou Chung‐Tei , Liao Hsien‐Tzung , Lin Yi‐Chun , Luo Shue‐Fen , Yang Deng‐Ho , Yeo Kai‐Jieh , Tsai Wen‐Chan ,   on behalf of the Taiwan Rheumatology Association (TRA)
Published: November 2019

AbstractAimTo establish guidelines for the clinical management of axial spondyloarthritis that take into account local issues and clinical practice concerns for Taiwan.MethodOverarching principles and recommendations were established by consensus among a panel of rheumatology and rehabilitation experts, based on analysis of the most up‐to‐date clinical evidence and the clinical experience of panelists. All Overarching Principles and Recommendations were graded according to the standards developed by the Oxford Centre for Evidence Based Medicine, and further evaluated and modified using the Delphi method.ResultsThe guidelines specifically address issues such as local medical considerations, National Health Insurance reimbursement, and management of extra‐articular manifestations.ConclusionIt is hoped that this will help to optimize clinical management outcomes for axial spondyloarthritis in Taiwan.
Collaborative implementation of stereotactic ablative body radiotherapy: A model for the safe implementation of complex radiotherapy techniques in Australia
Authors: Hau Eric , Hegi‐Johnson Fiona , Atkinson Charlotte , Barber Jeffrey , Browne Lois H , Chin Yaw , Dwyer Patrick , Graham Peter H , O'Hare Jolyne , Lu Dan , Rains Melissa , Ragusa Carolina , Schmidth Laurel , Small Katherine , Unicomb Kylie , West Katrina , White Sean , Last Andrew , Ludbrook Jane , Azzi Maria , Aherne Noel J , Van Tilburg Kevin , Vinod Shalini , Ma Xiaobing , Yeghiaian Alvandi Roland 
Published: November 2019

AbstractIntroductionStereotactic ablative radiotherapy (SABR) for lung cancer is a modality of treatment that has improved outcomes for lung cancer patients. However, radiotherapy for lung cancer is underutilized and fewer than half of elderly patients with non‐small cell lung cancer (NSCLC) receive active treatment. The purpose of this study is to report on a collaboration in implementing an NSCLC SABR (stereotactic ablative body radiation) program safely, efficiently, and uniformly across several centers, including regional sites. The first aim of this paper is to detail the collaboration and implementation that started in 2013 and is ongoing. The second aim of this paper is to document early toxicities and quality of life outcomes.MethodA tripartite approach was used to develop the protocol and networks required for the implementation of SABR across multiple sites in NSW. Departments starting the programmes were supported and physics credentialing with central site submission was required before commencing the treatment. Additional ongoing support was available via an email discussion group involving all members of the collaboration.ResultsBetween July 22, 2013 and February 22, 2016, 41 patients were enrolled with 34 patients in active follow up. The toxicity profile so far is similar to those of published studies with no appreciable effect on quality of life outcomes.ConclusionThe collaboration formed an effective framework in facilitating the implementation of SABR across several sites in NSW and could be used as a model for the safe and uniform implementation of new technologies in Australia.
SMPs’ Strategic Responses to Conflicting Normative, Material and Client Constraints
Authors: Malo Angélique , Fortin Anne , Héroux Sylvie 
Published: November 2019

AbstractThe objective of this study is to understand how small and medium audit practices (SMPs) deal with the obligation to conform to evolving norms, given their limited resources and the fact that they serve a client base of mainly small and medium‐sized enterprises (SMEs). Semi‐structured interviews held with 36 respondents working in 33 SMPs revealed that the main response of some SMPs’ to conflicting normative, material and client constraints was to eliminate the normative constraints by exiting the field to which the constraints pertained. When this was impossible, they resorted to less radical strategies. All strategies eventually led to adverse effects, including loss of expertise by some firms and practitioners, a condition that exacerbates the fragmentation within the accounting profession. Disenchanted by an increasingly demanding normative environment, the majority of respondents dealt with their disillusionment by mechanically applying the updates, a process that can lead to lower audit quality. Although the accounting profession was attempting to overcome a confidence crisis by issuing the updates, it ended up ignoring its less visible members and thus triggered upheavals with potentially irreversible consequences. In addition, banks may have been involved in narrowing the audit market for SMPs.
Impact of the pharmacist‐led intervention on the control of medical cardiovascular risk factors for the primary prevention of cardiovascular disease in general practice: A systematic review and meta‐analysis of randomised controlled trials
Authors: Alshehri Abdullah A. , Jalal Zahraa , Cheema Ejaz , Haque M. Sayeed , Jenkins Duncan , Yahyouche Asma 
Published: November 2019

AimsTo conduct a systematic review and meta‐analysis of the effectiveness of general practice‐based pharmacist interventions in reducing the medical risk factors for the primary prevention of cardiovascular events.MethodsA systemic search was undertaken in 8 databases: PubMed, MEDLINE, EMBAS, PsycINFO, Cochrane Library, CINAHL Plus, SCOPUS and Science Citation Index, with no start date up to 27 March 2019. Randomised controlled trials assessing the effectiveness of pharmacist‐led interventions delivered in the general practice in reducing the medical risk factors of cardiovascular events were included in the review. The risk of bias in the studies was assessed using the Cochrane risk of bias tool.ResultsA total of 1604 studies were identified, with 21 randomised controlled trials (8933 patients) meeting the inclusion criteria. Fourteen studies were conducted in patients with diabetes, 7 in hypertension, 2 involving dyslipidaemia, and 2 with hypertension and diabetes together. The most frequently used interventions were medication review and medication management. The quality of the included studies was variable. Patients receiving pharmacist‐led interventions were associated with a statistically significant reduction in their systolic blood pressure (−9.33 mmHg [95% Confidence Interval (CI) −13.36 to −5.30]), haemoglobin A1C (−0.76% [95% CI −1.15 to −0.37]) and low‐density lipoprotein–cholesterol (−15.19 mg/dL [95% CI −24.05 to −6.33]). Moreover, practice‐based pharmacists' interventions were also reported to have a positive impact on patient adherence to medications.ConclusionThe findings of this review suggest that pharmacist‐led interventions in general practice can significantly reduce the medical risk factors of cardiovascular disease events. These findings support the involvement of pharmacists as healthcare providers in managing patients with hypertension, diabetes and dyslipidaemia.
Birt‐Hogg‐Dubé syndrome‐associated renal cell carcinoma: Histopathological features and diagnostic conundrum
Authors: Furuya Mitsuko , Hasumi Hisashi , Yao Masahiro , Nagashima Yoji 
Published: November 2019

AbstractBirt‐Hogg‐Dubé (BHD) syndrome is associated with the development of hereditary renal cell carcinoma (RCC) and is caused by a germline mutation in the folliculin gene. Most cases of BHD syndrome‐associated RCC (BHD‐RCC) are less aggressive than sporadic clear cell RCC and multifocal. Therefore, it is critical to distinguish BHD‐RCC from its sporadic counterparts to identify and monitor affected families and to preserve renal function for as long as possible. The World Health Organization/International Society of Urological Pathology consensus classification defined distinct entities for certain hereditary RCC; however, BHD‐RCC was not included in this classification. Although the clinical features and molecular mechanisms of BHD‐RCC have been investigated intensively over the last two decades, pathologists and urologists occasionally face difficulties in the diagnosis of BHD‐RCC that require genetic testing. Affected patients usually have miscellaneous benign disorders that often precede renal carcinogenesis. In the present review, we summarize the current understanding of the histopathological features of BHD‐RCC based on our epidemiological studies of Japanese families and a literature review. Pathological diagnostic clues and differential diagnosis of BHD‐RCC from other hereditary RCC are also briefly discussed.
miR‐30e‐5p represses angiogenesis and metastasis by directly targeting AEG‐1 in squamous cell carcinoma of the head and neck
Authors: Zhang Shuiting , Li Guo , Liu Chao , Lu Shanhong , Jing Qiancheng , Chen Xiyu , Zheng Hua , Ma Huiling , Zhang Diekuo , Ren Shuling , Shen Zhe , Wang Yunyun , Lu Zhaoyi , Huang Donghai , Tan Pingqing , Chen Jie , Zhang Xin , Qiu Yuanzheng , Liu Yong 
Published: November 2019

AbstractMetastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). However, the mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine the key microRNA and their functional mechanisms involved in SCCHN metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used to quantify the level of miR‐30e‐5p in SCCHN and its clinical significance was further analyzed. A series of in vitro and in vivo experiments were applied to determine the effects of miR‐30e‐5p and its target AEG‐1 on SCCHN metastasis. A mechanism investigation further revealed that AEG‐1 was implicated in the angiogenesis and metastasis mediated by miR‐30e‐5p. Overall, our study confirms that miR‐30e‐5p is a valuable predictive biomarker and potential therapeutic target in SCCHN metastasis.
Immunological mechanisms underpinning faecal microbiota transplantation for the treatment of inflammatory bowel disease
Authors: Quraishi M N , Shaheen W , Oo Y H , Iqbal T H 
Published: November 2019

SummaryInflammatory bowel disease (IBD) is a chronic gastrointestinal disease that results from a dysregulated immune response against specific environmental triggers in a genetically predisposed individual. Increasing evidence has indicated a causal role for changes in gut microbiota (dysbiosis) contributing to this immune-mediated intestinal inflammation. These mechanisms involve dysregulation of multiple facets of the host immune pathways that are potentially reversible. Faecal microbiota transplantation (FMT) is the transfer of processed stool from a healthy donor into an individual with an illness. FMT has shown promising results in both animal model experiments and clinical studies in IBD in the resolution of intestinal inflammation. The underlying mechanisms, however, are unclear. Insights from these studies have shown interactions between modulation of dysbiosis via changes in abundances of specific members of the gut microbial community and changes in host immunological pathways. Unravelling these causal relationships has promising potential for a translational therapy role to develop targeted microbial therapies and understand the mechanisms that underpin IBD aetiopathogenesis. In this review, we discuss current evidence for the contribution of gut microbiota in the disruption of intestinal immune homeostasis and immunoregulatory mechanisms that are associated with the resolution of inflammation through FMT in IBD.
Interactions of the microbiota with the mucosal immune system
Authors: Bain C C , Cerovic V 
Published: November 2019

Summary
The field of mucosal immunology has, for the last 10 years, been largely dominated by advances in our understanding of the commensal microbiota. Developments of novel experimental methodologies and analysis techniques have provided unparalleled insight into the profound impact the microbiota has on the development and function of the immune system. In this cross-journal review series published in Immunology and Clinical and Experimental Immunology, we aim to summarize the current state of research concerning the interplay between the microbiota and mucosal immunity. In addition, the series examines how the increased understanding of the microbiota is changing the nature of immunological research, both in the laboratory and in the clinic.
Longitudinal anti-nuclear antibody (ANA) seroconversion in systemic lupus erythematosus: a prospective study of Swedish cases with recent-onset disease
Authors: Frodlund M , Wetterö J , Dahle C , Dahlström Ö , Skogh T , Rönnelid J , Sjöwall C 
Published: November 2019

Summary
Serum immunoglobulin (Ig)G anti-nuclear antibodies (ANA) detected by indirect immunofluorescence (IF) microscopy remains a hallmark of systemic lupus erythematosus (SLE). Whether or not IF-ANA status varies over time is controversial. We therefore designed a prospective study with longitudinal follow-up of patients with recent-onset SLE. The study population consisted of 54 recently diagnosed SLE cases, all meeting the 1982 American College of Rheumatology (ACR) and/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria. Clinical follow-up data, including disease activity, organ damage and sera, were collected from clinical onset of SLE and onwards, in most cases yearly (0‒96 months). IF-ANA was analysed on human epithelial cells-2 (HEp-2) cells and categorized regarding staining patterns. Using an addressable laser bead assay (FIDIS™ Connective profile), we measured IgG-ANA fine specificities against Ro52/SSA, Ro60/SSA, Sjögren’s syndrome type B antigen (La/SSB), Smith antigen (Sm), Smith antigen/ribonucleoprotein (Sm/RNP), U1 RNP (U1RNP), dsDNA, ribosomal-P protein and histone. At baseline, all patients were judged ANA-positive at an abnormal titre corresponding to the 95th percentile of healthy blood donors, but seven of 54 patients (13%) lost ANA-positivity over time. Homogeneous (AC-1; 46%) and speckled (AC-4 or 5; 31%) were the most frequently observed patterns at inclusion, whereas 7% switched pattern at least once during follow-up. Established associations between ANA fine specificities and clinical data were confirmed. Levels of anti-Sm/RNP, but not of anti-dsDNA, correlated with clinical disease activity [modified SLE disease activity 2000 (mSLEDAI-2K)]. Our data indicate that a considerable proportion of Swedish patients with SLE lose ANA-positivity over time, whereas consistent staining patterns were frequent. The clinical and mechanistic relevance of ANA seroconversion remains uncertain. Further prospective evaluations in larger SLE populations with more diverse ethnicities are warranted.
RAS: A Data‐Driven Rigidity‐Aware Skinning Model For 3D Facial Animation
Authors: Liu S‐L. , Liu Y. , Dong L‐F. , Tong X. 
Published: November 2019

AbstractWe present a novel data‐driven skinning model—rigidity‐aware skinning (RAS) model, for simulating both active and passive 3D facial animation of different identities in real time. Our model builds upon a linear blend skinning (LBS) scheme, where the bone set and skinning weights are shared for diverse identities and learned from the data via a sparse and localized skinning decomposition algorithm. Our model characterizes the animated face into the active expression and the passive deformation: The former is represented by an LBS‐based multi‐linear model learned from the FaceWareHouse data set, and the latter is represented by a spatially varying as‐rigid‐as‐possible deformation applied to the LBS‐based multi‐linear model, whose rigidity parameters are learned from the data by a novel rigidity estimation algorithm. Our RAS model is not only generic and expressive for faithfully modelling medium‐scale facial deformation, but also compact and lightweight for generating vivid facial animation in real time. We validate the efficiency and effectiveness of our RAS model for real‐time 3D facial animation and expression editing.