bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures
Authors: Gasmi Amin , Chirumbolo Salvatore , Peana Massimiliano , Mujawdiya Pavan Kumar , Dadar Maryam , Menzel Alain , Bjørklund Geir 
Published: September 2020

Abstract::
Human life expectancy is increasing significantly over time thanks to the improved
possibility for people to take care of themselves and the higher availability of food, drugs, hygiene,
services, and assistance. The increase in the average age of the population worldwide
is, however, becoming a real concern, since aging is associated with the rapid increase in
chronic inflammatory pathologies and degenerative diseases, very frequently dependent on
senescent phenomena that occur alongside with senescence. Therefore, the search for reliable
biomarkers that can diagnose the possible onset or predict the risk of developing a disease associated
with aging is a crucial target of current medicine. In this review, we construct a synopsis
of the main addressable biomarkers to study the development of aging and the associated
ailments.
Beneficiary and Adverse Effects of Phytoestrogens: A Potential Constituent of Plant-based Diet
Authors: Sridevi Vaadala , Naveen Ponneri , Karnam Venkat S. , Reddy Pamuru R. , Arifullah Mohammed 
Published: September 2020

Background:
Phytoestrogens are non-endocrine, non-steroidal secondary derivatives of plants and
consumed through a plant-based diet also named as “dietary estrogens”. The major sources of phytoestrogens
are soy and soy-based foods, flaxseed, chickpeas, green beans, dairy products, etc. The dietary inclusion of phytoestrogen
based foods plays a crucial role in the maintenance of metabolic syndrome cluster, including obesity,
diabetes, blood pressure, cancer, inflammation, cardiovascular diseases, postmenopausal ailments and their
complications. In recent days, phytoestrogens are the preferred molecules for hormone replacement therapy. On
the other hand, they act as endocrine disruptors via estrogen receptor-mediated pathways. These effects are not
restricted to adult males or females and identified even in development.

Objective:
Since phytoestrogenic occurrence is high at daily meals for most people worldwide, they focused to
study for its beneficiary effects towards developing pharmaceutical drugs for treating various metabolic disorders
by observing endocrine disruption.

Conclusion:
The present review emphasizes the pros and cons of phytoestrogens on human health, which may
help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various
metabolic disorders.
Why Iranian Women Experience Work-Family Conflict?
Authors: Taghizadeh Ziba , Ebadi Abbas , Keshavarz Sedigheh , Pourreza Abolghasem , Kazemnejad Anoshirvan , Bagherzadeh Razieh 
Published: September 2020

Background:
Despite the global importance of work-family issues and the many calls for studies within
distinct cultural contexts; work-family research has mainly been conducted in Anglo societies, and Western countries.

Objective:
The present study was designed to explore the factors which determine work-family conflict through personal
information including, but not limited to the lived experiences and perspectives of Iranian women who are both employed
and married.

Methods:
A qualitative approach was chosen which would allow for an in-depth and rich exploration of the experiences,
perceptions, and feelings of participants. Data were obtained from 29 participants. In-depth individual interviews with 17
participants and two focus groups. Each focus group discussion included 6 participants.

Results:
Six main categories emerged from the data analysis: the value of work and family, hegemonic masculinity, nonsupportive environment, job stress, overloading family, and inadequacy of individual ability and skills.

Conclusion:
Based on data obtained from participants, sociocultural factors play an important role in the creation of
work-family conflict.
Covalent-driven Layer-by-layer Self-assembly of Clindamycin-loaded PPLA Nanoparticles/chitosan Membrane on Titanium Sheet for Longacting Anti-infection
Authors: Yang Shuangya , Yin Yan , Xu Yajuan , Zhang Tanglin , Li Youbin , Fei Jun , Huang Xiao 
Published: September 2020

Background:Post-arthroplasty implant-related infection is one of the most feared complications with adverse consequences for patients and public health systems, especially in terms of the huge financial cost of treatment. This is compounded by the potential risks of continuous metamorphosis and emergence of new resistant bacterial strains. Constructing an antibacterial surface, therefore, on the implant represents an approach to reduce the incidence of implant-related infections.Methods:In this study, a covalent-driven layer-by-layer self-assembly of clindamycin-loaded polyethylene glycol grafted polylactic acid nanoparticles/chitosan membrane has been successfully fabricated on the titanium sheet and evaluated for drug releasing potential and antibiotic activity.Results:Attenuated total reflectance spectrum of the layer-by-layer self-assembly membrane showed three absorption peaks around 1680, 1520 and 1240 cm-1, which are the characteristic absorption peaks of secondary amines. The results indicated the formation of an amide bond between the carboxyl groups of clindamycin-loaded polyethylene glycol grafted polylactic acid nanoparticles and the amino groups of chitosan. The covalent bond stabilized the membrane construct. The membrane exhibited a sustained drug release behavior whereby less than 50% of clindamycin was released after 160 hr. The membrane persistently inhibited the growth of Staphylococcus aureus with the inhibition ratio exceeding 60%.Conclusion:The membrane construct holds a great potential for managing anti-implant-related infections.
Psychometric Properties of the Japanese Version of the Single Dental Anxiety Question: A Cross-sectional Online Survey
Authors: Ogawa Mika , Sago Teppei , Lahti Satu , Taniguchi Shogo 
Published: September 2020

Background:
Assessment of dental anxiety using a validated questionnaire is important for its management and survey.

Objective:
The aim of this cross-sectional online survey was to evaluate the psychometric properties of the Japanese version of the Single Dental Anxiety Question (SDAQ).

Methods:
The single question was translated into Japanese following the forward-backward method. Four hundred Japanese internet monitors (age 20–79 years) were included in the study. Sensitivity–specificity analysis and the Kappa coefficient were calculated against the Modified Dental Anxiety Scale (MDAS) using the 19 cutoff score for high dental anxiety. Criterion validity was evaluated using age, gender, dental attendance pattern, negative dental experiences, and subjective oral health.

Results:
Among these subjects, 11% were found to have high dental anxiety on the MDAS score and 9% rated themselves as very afraid of SDAQ. The Kappa coefficient between the MDAS cutoff score and the SDAQ classification was 0.58, the sensitivity was 0.56, and the specificity was 0.97. The SDAQ was associated with gender (P = 0.018), dental attendance pattern (P = 0.020), negative dental experiences (P < 0.001), and subjective oral health (P < 0.001).

Conclusion:
The Japanese version of the SDAQ has good criterion and construct validity but lower sensitivity than the original version. It can be used to assess dental anxiety in large dental surveys or clinical settings where a multi-item questionnaire is not feasible.
Isolation and Characterization of Staphylococcus aureus From Food of Bovine Origin in Mekelle, Tigray, Ethiopia
Authors: Weldeselassie Million , Gugsa Getachew , Kumar Ashwani , Tsegaye Yisehak , Awol Nesibu , Ahmed Meselu , Abebe Nigus , Taddele Habtamu 
Published: September 2020

Background:Among Food-borne diseases,S. aureusis a leading cause of gastroenteritis resulting from the consumption of contaminated food.Objectives:The study aimed to isolate and characterizeS. aureusfrom raw milk, yogurt and meat and determine its antibiotic sensitivity pattern.Materials and Methods:A cross-sectional study was conducted from December 2014 to June 2015 in Mekelle. A total of 284 samples were collected purposively. Enumeration of total viable bacteria count (TVBC), bacteriological isolation and identification, antimicrobial susceptibility testing, as well as PCR amplification offem Aandmec Agenes were performed. Chi-square (χ2) and one way ANOVA tests were used for analysis.Results:Overall TVBC mean was found to be 1.29x108cfu/ml/g. The highest TVBC (1.38x108cfu/ml) was from the yogurt sample and the lowest (1.26x108cfu/g) was from meat. The overall prevalence of coagulase positiveS. aureus(CoPS) was 39.1% (111) and of the smaples, 51(56.04%), 38(26.20%) and 22(45.83%) were isolated from meat, raw milk, and yogurt, respectively. There was a statistically significant difference (p<0.05) among the different sample types and sources in the prevalence ofS. aureus. Almost half of the CoPS isolates were sensitive to Tetracycline, Gentamycin, and Kanamycin, but resistant to Amoxicillin (96.9%) and Penicillin G (93.8%). Moreover, 93.75% of the isolates developed multidrug resistance. All isolates carried thefem Agene and among these isolates, 12 (37.5%) carriedmec Agene.Conclusion:The present study revealed that foods of bovine origin of the study area are found to be having less bacteriological quality, high prevalence of CoPS and development of drug resistance.
Novel Polypseudorotaxanes Hydrogel based Nail Lacquer of Efinaconazole for Transungual Drug Delivery
Authors: Aggarwal Rohan , Targhotra Monika , Kumar Bhumika , Sahoo P.K , Chauhan Meenakshi K. 
Published: September 2020

Aim:
Due to the various drawbacks associated with current treatment therapy of onychomycosis,
the main aim was to develop thermosensitive hydrogels and thermosensitive polypseudorotaxanes
hydrogels-based nail lacquer for transungual delivery of Efinaconazole for the management
of onychomycosis. The objective is to enhance the permeation and retention of the drug in
the nails and improve patient compliance.

Methods::
Poloxamer 407 and Hydroxy Propyl-β-cyclodextrin were used to prepare the nail lacquers.
2-mercaptoethanol was added as a penetration enhancer to improve the penetration of the
drug across the nail plate. The formulations were optimized by varying the concentration of poloxamer
and water: ethanol ratio and evaluated based on the basis of drying time, sol-gel transition
temperature, ex vivo drug release, and viscosity. The optimized formulation was further evaluated
for pH, water resistance, non-volatile content, drug content, blush test, spreadability, and stability
studies.

Results:
The increase in ethanol concentration and reduction in poloxamer proportion led to a reduction
in lacquer stickiness thus, improving the lacquer drying time and penetration. The polypseudorotaxanes
improved the permeation profile of the drug in comparison to the marketed nail
lacquer. The presence of 2-mercaptoethanol also contributed to the transungual delivery of Efinaconazole.

Conclusion::
The polypseudorotaxanes based nail lacquer with the incorporation of penetration enhancer
was able to achieve a high rate of drug penetration and retention, thus supporting the potential
use of aqueous based-nail lacquer in transungual drug delivery for the onychomycosis treatment.
DFT Study and Synthesis of Novel Bioactive Bispyrazole using Mg/Al-LDH as a Solid Base Catalyst
Authors: Akhramez Soufiane , Achour Youness , Dib Mustapha , Bahsis Lahoucine , Ouchetto Hajiba , Hafid Abderrafia , Khouili Mostafa , El Haddad Mohammadine 
Published: September 2020

Objective:
To synthesize novel bispyrazole heterocyclic molecules may have important
biological activities and thus can serve as good candidates for pharmaceutical applications.

Methods:
The bispyrazole derivatives 3a-m were prepared by the condensation reaction of
substituted aromatic aldehydes with 1,3-diketo-N-phenylpyrazole by using Mg/Al-LDH as a
heterogeneous catalyst under THF solvent at the refluxing temperature.

Results:
This protocol describes the synthesis of bioactive compounds under mild reaction
conditions, with good yields, and easiness of the catalyst separation from the reaction mixture.
Furthermore, a mechanistic study has been performed by using DFT calculations to explain
the observed selectivity of the condensation reaction between aryl aldehyde and 1,3-
diketo-N-phenylpyrazole via Knoevenagel reaction. The local electrophilicity/ nucleophilicity
explains correctly the experimental finding.

Conclusion:
In summary, the pharmacologically interesting bis-pyrazole derivatives were
synthesized through Mg/Al-LDH as a solid base catalyst, in THF as a solvent. The synthesized
bioactive compounds containing the pyrazole ring may have important biological activities
and thus can serve as good candidates for pharmaceutical applications. Therefore, the
catalyst Mg/Al-LDH showed high catalytic activity. Besides, a series of bispyrazole molecules
were synthesized with a good yield and easy separation of the catalyst by simple filtration.
Moreover, DFT calculations and reactivity indexes were used to explain the selectivity of the
condensation reaction between aryl benzaldehyde and 1,3-diketo-N-phenylpyrazole via
Knoevenagel reaction, and the results were in good agreement with the experimental finding.
Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin
Authors: Pawar Harshal A. , Bhangale Bhagyashree D. 
Published: September 2020

Background:
Lipid based excipients have increased acceptance nowadays
in the development of novel drug delivery systems in order to improve their
pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability
due to the protection they experience in the lipid core of these nano-formulations.
Phytosomes are newly discovered drug delivery systems and novel botanical
formulation to produce lipophilic molecular complex which imparts stability,
increases absorption and bioavailability of phytoconstituent. Curcumin, obtained
from turmeric (Curcuma longa), has a wide range of biological activities. The
poor solubility and wettability of curcumin are responsible for poor dissolution
and this, in turn, results in poor bioavailability. To overcome these limitations,
the curcumin-loaded nano phytosomes were developed to improve its physicochemical
stability and bioavailability.

Objective:
The objective of the present research work was to develop nano-phytosomes
of curcumin to improve its physicochemical stability and bioavailability.

Methods:
Curcumin-loaded nano phytosomes were prepared by using phospholipid
Phospholipon 90 H using a modified solvent evaporation method. The developed
curcumin nano phytosomes were evaluated by particle size analyzer and
differential scanning calorimetry (DSC).

Results:
Results indicated that phytosomes prepared using curcumin and lipid in
the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes
were spherical in shape with a size less than 100 nm. The prepared nano
phytosomal formulation of curcumin showed promising potential as an antioxidant.

Conclusion:
The phytosomal complex showed sustained release of curcumin
from vesicles. The sustained release of curcumin from phytosome may improve
its absorption and lowers the elimination rate with an increase in bioavailability.
Impact of COVID-19 on Mental Dimension of Health: A Sensitive Issue to be Addressed at the Earliest
Authors: Nepal Sunil , Nepal Sudip , Shastry Chakrakodi S. , Chand Sharad , Nandakumar U.P. , Pant Bishnu Dev , Khanal Pukar , Rawal Kala Bahadur 
Published: September 2020

Background:
The novel coronavirus disease outbreak of 2019 was declared as a public
health emergency by the World Health Organization. At present, the virus has spread throughout the
world, leading to millions of cases and is further increasing.

Objective:
The main objective of this study is to review the impact of Corona Virus Disease 2019
(COVID-19) on the mental health of frontline workers, isolated and quarantined people and the
general population.

Methods:
The relevant articles were extracted from PubMed, Web of Science and ScienceDirect
database by using the keywords “Mental health”, “COVID-19”, “Impact of COVID-19”, “Frontline
workers”, “Quarantine”, “Isolation”, “Immunity” and “Economy”. The retrieved articles were included
in the study based on inclusion criteria to perform the review. All the selected scientific articles
were critically reviewed and the information is summarized in this narrative review.

Results:
The majority of the studies stated that frontline health workers were at an increased risk of
depression. The infected, suspects and quarantined people were reported with high stress, posttraumatic
stress disorder, and suicidal thoughts. The pandemic has devastated the world’s economy,
which has severely impacted global mental health.

Conclusion:
Mental health should be taken into account, and necessary interventional initiatives
need to be considered both by the health authorities and the government to minimize the adversity
of the consequences. The pandemic may disappear with the discovery of new vaccines or medications,
but its negative impact on mental health may persist, particularly among vulnerable populations.
Thus, mental health must be a matter of concern in the present scenario.
Coronavirus: History, Genome Structure and Pathogenesis
Authors: Poonam B. , Gill Prabhjot Kaur 
Published: September 2020

Background:
The positive sense and inordinate large RNA genome enclosed by helical nucleocapsids
along with an outermost layer belongs to the family Coronaviridae. The phylogenetic tree of
this family has been classified into Class1 as alpha, Class 2 as beta, Class 3 as gamma, and Class 4 as
delta CoV. The mammalian respiratory and gastrointestinal tracts are the main target organs of this enveloped
virus with misperceived mechanisms. The relevance of this virus family has considerably increased
by the recent emergence of the Severe Acute Respiratory Syndrome (SARS) and Middle East
Respiratory Syndrome (MERS), which are caused by viruses that belong to the beta-CoV group.

Aim:
Aforesaid illustrations of the emergence of coronavirus diseases over the past two decades, SARS
(2002; 2003) and MERS (2012 to present) - the ongoing COVID-19 outbreak has pressurized the WHO
to take innovative measures for public health, research and medical communities. The aim of the present
review is to have proficiency in the coronavirus replication and transcription process which is still in its
infancy.

Conclusion:
As an outcome of epidemics, it is being recognized as one of the most advancing viruses by
the virtue of high genomic nucleotide substitution rates and recombination. The hallmark of coronavirus
replication is discontinuous transcription resulting in the production of multiple subgenomic mRNAs
having sequences complementary to both ends of the genome. Therefore, the complete genome sequence
of coronavirus will be used as a frame of reference for comprehending this classical phenomenon
of the RNA replication process. Finally, research on the pathogenesis of coronaviruses and the host
immunopathological response will aid in designing vaccines and minimizing the mortality rate.
Use of an Internet-of-Things Smart Home System for Healthy Aging in Older Adults in Residential Settings: Pilot Feasibility Study
Authors: Choi Yong K , Thompson Hilaire J , Demiris George 
Published: September 2020

Background
The Internet-of-Things (IoT) technologies can create smart residences that integrate technology within the home to enhance residents’ safety as well as monitor their health and wellness. However, there has been little research on real-world testing of IoT smart home devices with older adults, and the feasibility and acceptance of such tools have not been systematically examined.

Objective
This study aims to conduct a pilot study to investigate the feasibility of using IoT smart home devices in the actual residences of older adults to facilitate healthy aging.

Methods
We conducted a 2-month feasibility study on community-dwelling older adults. Participants chose among different IoT devices to be installed and deployed within their homes. The IoT devices tested varied depending on the participant’s preference: a door and window sensor, a multipurpose sensor (motion, temperature, luminosity, and humidity), a voice-operated smart speaker, and an internet protocol (IP) video camera.

Results
We recruited a total of 37 older adults for this study, with 35 (95%) successfully completing all procedures in the 2-month study. The average age of the sample was 78 (SD 9) years and primarily comprised women (29/37, 78%), those who were educated (31/37, 86%; bachelor’s degree or higher), and those affected by chronic conditions (33/37, 89%). The most widely chosen devices among the participants were multipurpose sensors and smart speakers. An IP camera was a significantly unpopular choice among participants in both phases. The participant feedback suggests that perceived privacy concerns, perceived usefulness, and curiosity to technology were strong factors when considering which device to have installed in their home.

Conclusions
Overall, our deployment results revealed that the use of IoT smart home devices is feasible in actual residences of older adults. These findings may inform the follow-up assessment of IoT technologies and their impact on health-related outcomes and advance our understanding of the role of IoT home-based monitoring technologies to promote successful aging-in-place for older adults. Future trials should consider older adults’ preferences for the different types of smart home devices to be installed in real-world residential settings.