bluuebunny/crossref_metadata_2025_split huggingface dataset:
The granite porphyry hidden in the Shuangjianzishan deposit, southern Great Xing’an Range, NE China: geochronology, isotope geochemistry and tectonic implications
Authors: Wei Wei , Lv Xin-Biao , Wang Xiang-Dong 
Published: October 2020

AbstractThe Shuangjianzishan vein-type Ag-Pb-Zn deposit in the southern Great Xing’an Range (GXR), NE China, is hosted in the slate of the Lower Permian Dashizhai Formation intruded by granite porphyry. In this paper, U–Pb zircon ages and bulk-rock and isotope (Sr, Nd, Pb and Hf) compositions are reported to investigate the derivation, evolution and geodynamic setting of this granite porphyry. It is closely associated with Pb-Zn-Ag mineralization in the southern GXR and contains important geological information relating to regional tectonic evolution. Laser ablation – inductively coupled plasma – mass spectrometry (LA-ICP-MS) zircon U–Pb dating yields an emplacement age of 131 ± 1 Ma for the granite porphyry. Bulk-rock analyses show that the Shuangjianzishan granite porphyry is characterized by high Si, Na and K contents but low Mg and Fe contents, and that the enrichment of Zr, Y and Ga suggests an A-type granite affinity. Most of the studied samples have relatively low 87Sr/86Sr values (0.70549–0.70558), with positive ϵNd(t) (0.71–0.88) and ϵHf(t) (4.9–6.9) values. The Sr–Nd isotope modelling results, in combination with the young TDM2 ages of Nd and Hf (850–864 and 668–778 Ma, respectively), reveal that the Shuangjianzishan granite porphyry may be derived from the melting of mantle-derived juvenile component, with minor lower crustal components; this finding is also supported by Pb isotopic compositions. Considering the widespread presence of granitoids with coeval volcanic rocks and regional geology data, we propose that the Shuangjianzishan granite porphyry formed in a post-orogenic extensional environment related to the upwelling of asthenospheric mantle following the closure of the Mongol–Okhotsk Ocean.
Alexithymia in autism: cross-sectional and longitudinal associations with social-communication difficulties, anxiety and depression symptoms
Authors: Oakley Bethany F. M. , Jones Emily J. H. , Crawley Daisy , Charman Tony , Buitelaar Jan , Tillmann Julian , Murphy Declan G. , Loth Eva ,   The EU-AIMS LEAP Group
Published: October 2020

AbstractBackgroundAlexithymia (difficulties in identifying and describing emotion) is a transdiagnostic trait implicated in social–emotional and mental health problems in the general population. Many autistic individuals experience significant social-communication difficulties and elevated anxiety/depression and alexithymia. Nevertheless, the role of alexithymia in explaining individual variability in the quality/severity of social-communication difficulties and/or anxiety and depression symptoms in autism remains poorly understood.MethodsIn total, 337 adolescents and adults (autism N = 179) were assessed for alexithymia on the Toronto Alexithymia Scale and for social-communication difficulties, anxiety and depression symptoms. A total of 135 individuals (autism N = 76) were followed up 12–24 months later. We used regression models to establish cross-sectional and longitudinal associations between alexithymia, social-communication difficulties, anxiety and depression symptoms.ResultsAutistic individuals reported significantly higher alexithymia than comparison individuals (p < 0.001, r effect size = 0.48), with 47.3% of autistic females and 21.0% of autistic males meeting cut-off for clinically relevant alexithymia (score ⩾61). Difficulties in describing feelings were particularly associated with current self-reported social-communication difficulties [p < 0.001, β = 0.57, 95% confidence interval (CI) 0.44–0.67] and predicted later social-communication difficulties (p = 0.02, β = 0.43, 95% CI 0.07–0.82). Difficulties in identifying feelings were particularly associated with current anxiety symptom severity (p < 0.001, β = 0.54, 95% CI 0.41–0.77) and predicted later anxiety (p = 0.01; β = 0.31, 95% CI 0.08–0.62).ConclusionsOur findings suggest that difficulties in identifying v. describing emotion are associated with differential clinical outcomes in autism. Psychological therapies targeting emotional awareness may improve social-communication and anxiety symptoms in autism, potentially conferring long-term benefits.
PREDICTIVE PROCESSING OF IMPLICIT CAUSALITY IN A SECOND LANGUAGE
Authors: Kim Hyunwoo , Grüter Theres 
Published: October 2020

AbstractImplicit causality (IC) is a well-known phenomenon whereby certain verbs appear to create biases to remention either their subject or object in a causal dependent clause. This study investigated to what extent Korean learners of English made use of IC information for predictive processing at a discourse level, and whether L2 proficiency played a modulating role in this process. Results from a visual-world eye-tracking experiment showed early use of IC information in both L1 and L2 listeners, yet the effect was weaker and emerged later in the L2 group. None of three independent and intercorrelated proficiency measures modulated L2 listeners’ processing behavior. The findings suggest that L2 listeners are able to engage in prediction during real-time processing at a discourse level, although they did so to a more limited extent than native speakers in this study. We discuss these findings in light of similar evidence from other recent work.
Flint Kids Cook: positive influence of a farmers’ market cooking and nutrition programme on health-related quality of life of US children in a low-income, urban community
Authors: Saxe-Custack Amy , LaChance Jenny , Hanna-Attisha Mona , Dawson Chantel 
Published: October 2020

AbstractObjective:To examine changes in health-related quality of life (HRQoL) among youth who participated in Flint Kids Cook, a 6-week healthy cooking programme for children, and assess whether changes in HRQoL were associated with changes in cooking self-efficacy, attitude towards cooking (ATC) and diet.Design:Pre-post survey (Pediatric Quality of Life Inventory, Block Kids Food Screener, 8-item cooking self-efficacy, 6-item ATC) using child self-report at baseline and programme exit. Analysis involved paired sample t-tests and Pearson’s correlations.Setting:Farmers’ market in Flint, Michigan, USA.Participants:Children (n 186; 55·9 % female, 72·6 % African American) participated in Flint Kids Cook from October 2017 to February 2020 (mean age 10·55 ± 1·83 years; range 8–15).Results:Mean HRQoL summary score improved (P < 0·001) from baseline (77·22 ± 14·27) to programme exit (81·62 ± 14·43), as did mean psychosocial health summary score (74·68 ± 15·68 v. 79·04 ± 16·46, P = 0·001). Similarly, physical (P = 0·016), emotional (P = 0·002), social (P = 0·037), and school functioning (P = 0·002) improved. There was a correlation between change in HRQoL summary score and change in ATC (r = –0·194, P = 0·025) as well as change in cooking self-efficacy (r = –0·234, P = 0·008). Changes in HRQoL and psychosocial health summary scores were not correlated with dietary changes, which included decreased added sugar (P = 0·019) and fruit juice (P = 0·004) intake.Conclusions:This study is the first to report modest yet significant improvements in HRQoL among children and adolescents who participated in a healthy cooking programme. Results suggest that cooking programmes for youth may provide important psychosocial health benefits that are unrelated to dietary changes.
‘Devenir compositeur’: Notes on the Insertion of Argentine Composers in the Contemporary French Music Scene (1970–2000)
Authors: LIUT MARTIN 
Published: October 2020

AbstractThis article studies a group of nineteen Argentinean composers who settled in Paris between 1970 and 2000. In addition to social and political factors of Argentine history – including the last military dictatorship (1976–83) and the 1989 period of ‘hyperinflation’ (1989) – these composers wanted to develop their careers in a professional field with the history, size, and diversity of Paris. Since the 1970s, France began a strong state policy supporting the arts; this action promoted a process of internationalization of Paris's artistic life. Contemporary music was viewed by participants and creators as an open and cosmopolitan space. Although the paradigm of autonomy suggests that nationality is less relevant than the individuality of each composer, the latter continues to function as an identity marker and, therefore, as a classification strategy both in France and in Argentina.
Cardiovascular risk factors in those born preterm – systematic review and meta-analysis
Authors: Andraweera Prabha H. , Condon Bradley , Collett Gemma , Gentilcore Stefania , Lassi Zohra S. 
Published: October 2020

AbstractEmerging evidence demonstrates a link between preterm birth (PTB) and later life cardiovascular disease (CVD). We conducted a systematic review and meta-analysis to compare conventional CVD risk factors between those born preterm and at term. PubMed, CINAHL, SCOPUS, and EMBASE databases were searched. The review protocol is registered in PROSPERO (CRD42018095005). CVD risk factors including systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index, lipid profile, blood glucose, and fasting insulin among those born preterm (<37 weeks’ gestation) were compared with those born at term (≥37 weeks’ gestation). Subgroup analyses based on gender, age, gestational at birth (<32 weeks’ gestation and <28 weeks’ gestation), and PTB associated with small for gestational age or average for gestational age were also performed. Fifty-six studies provided data on 308,987 individuals. Being born preterm was associated with 3.26 mmHg (95% confidence interval [CI] 2.08 to 4.44) higher mean SBP and 1.32 mmHg (95% CI: 0.61 to 2.04) higher mean DBP compared to being born at term. Subgroup analyses demonstrated that SBP was higher among (a) preterm compared to term groups from early adolescence until adulthood; (b) females born preterm but not among males born preterm compared to term controls; and (c) those born at <32 weeks or <28 weeks compared to term. Our meta-analyses demonstrate higher SBP and DBP among those born preterm compared to term. The difference in SBP is evident from early adolescence until adulthood.
The Hmong and the Communist Party of Thailand: A Transnational, Transcultural and Gender-Relations-Transforming Experience
Authors: Baird Ian G. 
Published: October 2020

AbstractBeginning in the early 1960s—and especially by the end of the decade—a large number of the ethnic Hmong people in Thailand aligned themselves with the Communist Party of Thailand (CPT). By the 1970s, most of the CPT's “liberated areas” were located in remote, mountainous areas populated by Hmong people. In this paper, I situate Hmong involvement in CPT through the literature related to the multi-ethnic connections being made through the organisation of armed groups and argue that Hmong involvement with the CPT was transnational, transcultural and gender-relations-transforming. The first Hmong Thai to join the CPT was recruited in neighbouring Laos. Other Hmong in Thailand heard about the CPT through radio broadcasts from Laos in Hmong language. Furthermore, many of the early CPT recruits travelled from their homes in Thailand for political and military instruction at a basic training centre called A-30, which was located somewhere in northern Laos near the border with China. There, most Hmong CPT recruits learned to speak, read and write central Thai language. Hmong CPT also started to meaningfully interact with other Thais, including those from northeastern and southern Thailand and Chinese Thais from Bangkok. Later, those deemed to have particular potential were sent to study in China or in Vietnam for specific military training. Some Hmong sent their children to study with the CPT; others went on their own. The Hmong also interacted with people from other communist movements in Southeast Asia.
Der Inno-Lehre
Authors: Stasewitsch Elena , Kauffeld Simone 
Published: October 2020

Zusammenfassung. Der Inno-Lehre wurde angelehnt an den Center-of-Excellence-Ansatz und an den aktuellen Diskurs über innovative Hochschullehre entwickelt, um das Innovationsklima in der Hochschullehre zu messen. 162 Lehrende und 585 Studierende verschiedener deutschsprachiger Hochschulen haben den Inno-Lehre ausgefüllt. Mit Hilfe einer explorativen Faktorenanalyse und Analyse der Itemkennwerte wurde eine 12-faktorielle Struktur des Inno-Lehre festgelegt. Die faktorielle Struktur des Inno-Lehre konnte durch eine konfirmatorische Faktorenanalyse bestätigt werden. Der Inno-Lehre korreliert positiv mit Skalen zur Studien- und Leistungszufriedenheit von Studierenden und gibt so Hinweise auf die konvergente Validität. Zwischen dem Inno-Lehre und Persönlichkeitsmerkmalen der Organisationsangehörigen zeigen sich keine bzw. geringe Korrelationen, was im Sinne der diskriminanten Validität interpretiert werden kann. Zusammenfassend ermöglicht der Inno-Lehre die standardisierte und ökonomische Erfassung des lehrbezogenen Innovationsklimas.
The Impact on the Ozone Layer of a Potential Fleet of Civil Hypersonic Aircraft
Authors: Kinnison Douglas , Brasseur Guy P. , Baughcum Steven L. , Zhang Jun , Wuebbles Donald 
Published: October 2020

AbstractThe aeronautical community is currently researching technology that might lead to commercial hypersonic aircraft that would cruise at Mach 5–8 in the middle or upper stratosphere and would transfer passengers from London to New York or from Los Angeles to Tokyo in just a couple of hours. Depending on the engine technology to be adopted, these aircraft will potentially release substantial amounts of water vapor and nitrogen oxides around 30–40 km altitude. We show here that the operation of a large fleet of such aircraft could potentially deplete considerable amounts of ozone in the stratosphere, which would lead to a substantial increase in biologically damaging ultraviolet radiation reaching the Earth's surface. The calculations are based on a specific emission scenario, which carries large uncertainties but can easily be scaled to account for the type of aircraft engine to be eventually adopted, improved technology to be expected, and the size and operation conditions of the future aircraft fleet.
Prepare Scientists to Engage in Science‐Policy
Authors: von Schneidemesser Erika , Melamed Megan , Schmale Julia 
Published: October 2020

AbstractThere is a dire need for deeper science‐policy engagement to face recent developments such as entering into the Anthropocene and our dependence as a species on technological and scientific advancements. However, there is a lack of preparedness and training of scientists about what science‐policy engagement is and how to get involved, with substantial discrepancies globally. We present four gaps and possible solutions to those gaps to better train and prepare scientists to engage in science‐policy. (1) Frame science‐policy as a system. The framing of a science‐policy interface is misleading. A better framing is the science‐policy system, in which two processes, science and policy, are under the influence of each other. (2) Teach the science‐policy system. Scientists should have a basic understanding of what the science‐policy system is, and the implications that has for their research. (3) Engage in the science‐policy system. Make the research on science‐policy more readily accessible to the users and share experiences and lessons learned from those that have engaged in science‐policy to foster greater engagement. (4) Value engagement in the science‐policy system. Scientific institutions need to place greater value on science‐policy engagement by setting up structures, award systems, and incentives for scientists to engage science‐policy.
Plasma Convection in the Terrestrial Magnetotail Lobes Measured Near the Moon's Orbit
Authors: Cao Xin , Halekas Jasper S. , Chu Feng , Kistler Michael , Poppe Andrew R. , Glassmeier Karl‐Heinz 
Published: October 2020

AbstractIn order to study the plasma convection in the deep magnetotail lobes near lunar orbit, we investigated ions originating from the tenuous exosphere and surface of the Moon, which are measured by the Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) spacecraft. Directly measuring the plasma convection in the tail lobes is difficult, due to the typically large positive spacecraft potential. In this work we show that in the terrestrial magnetotail near the Moon, the convection velocity can be estimated by measuring the velocity of lunar ions. Determining what factors control the lobe convection is important in understanding the linkage between the upstream conditions and the dynamics of the tail lobes. Based on systematic analysis of multiple ARTEMIS observations and OMNI data, we find that the interplanetary magnetic field (IMF) and magnetospheric activity plays an important role in controlling plasma convection in the near‐Moon lobes.
Comparative Study of Cloud Liquid Water and Rain Liquid Water Obtained From Microwave Radiometer and Micro Rain Radar Observations Over Central China During the Monsoon
Authors: Zhang Wengang , Xu Guirong , Xi Baike , Ren Jing , Wan Xia , Zhou Lingli , Cui Chunguang , Wu Dongqiao 
Published: October 2020

AbstractWe investigated the cloud liquid water (CLW) and rain liquid water (RLW) during weak precipitations (rain rate below 12 mm/h) using microwave radiometer and microrain radar measurements collected by the Integrative Monsoon Frontal Rainfall Experiment over central China in 2018. The CLW path increased sharply from 0.6 to 4.1 mm for precipitation clouds. RLW path presented a similar trend, although it had a larger correlation coefficient with rain rate. Precipitation efficiency reached up to ~50% and then clearly decreased as precipitation weakened. Because weak precipitation is mostly formed in stable nimbostratus, CLW content (CLWC) during precipitation tends to has a quasi‐normal distribution with mode at 0.38 g/m3, whereas RLW content (RLWC) shows a positively skewed distribution with mode at 0.06 g/m3. Normalized CLWC initially increases then decreases with height in nonprecipitation clouds but varies slightly in precipitation clouds due to relatively monodispersed droplets in the weaker convective motion. CLWC derived from millimeter‐wave cloud radar (MMCR) shows similar vertical distribution but with larger values. The mean normalized CLWCs are 0.06 and 0.38 g/m3 for nonprecipitation and precipitation clouds, respectively. RLWC varies slightly with height with a mean of 0.22 g/m3 because both the collision and breakup of raindrops are weak. A case study showed different distributions and vertical structures of CLWC and RLWC in various stages of precipitation. Thicker clouds result in larger CLWC and RLWC, which will cause greater rain rate. This qualitatively explains relationships among cloud thickness, CLW, RLW, and rain rate in precipitation during the monsoon.
SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
Authors: Chen Hao , Libring Sarah , Ruddraraju Kasi Viswanatharaju , Miao Jinmin , Solorio Luis , Zhang Zhong-Yin , Wendt Michael K. 
Published: October 2020

AbstractMetastatic breast cancer (MBC) is an extremely recalcitrant disease capable of bypassing current targeted therapies via engagement of several growth promoting pathways. SH2 containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase known to facilitate growth and survival signaling downstream of numerous receptor inputs. Herein, we used inducible genetic depletion and two distinct pharmacological inhibitors to investigate the therapeutic potential of targeting SHP2 in MBC. Cells that acquired resistance to the ErbB kinase inhibitor, neratinib, displayed increased phosphorylation of SHP2 at the Y542 activation site. In addition, higher levels of SHP2 phosphorylation, but not expression, were associated with decreased survival of breast cancer patients. Pharmacological inhibition of SHP2 activity blocked ERK1/2 and AKT signaling generated from exogenous stimulation with FGF2, PDGF, and hGF and readily prevented MBC cell growth induced by these factors. SHP2 was also phosphorylated upon engagement of the extracellular matrix (ECM) via focal adhesion kinase. Consistent with the potential of SHP2-targeted compounds as therapeutic agents, the growth inhibitory property of SHP2 blockade was enhanced in ECM-rich 3D culture environments. In vivo blockade of SHP2 in the adjuvant setting decreased pulmonary metastasis and extended the survival of systemic tumor-bearing mice. Finally, inhibition of SHP2 in combination with FGFR-targeted kinase inhibitors synergistically blocked the growth of MBC cells. Overall, our findings support the conclusion that SHP2 constitutes a shared signaling node allowing MBC cells to simultaneously engage a diversity of growth and survival pathways, including those derived from the ECM.
The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein
Authors: Torkzaban Bahareh , Natarajaseenivasan Kalimuthusamy , Mohseni Ahooyi Taha , Shekarabi Masoud , Amini Shohreh , Langford T. Dianne , Khalili Kamel 
Published: October 2020

AbstractHIV-1 Tat is a potent neurotoxic protein that is released by HIV-1 infected cells in the brain and perturbs neuronal homeostasis, causing a broad range of neurological disorders in people living with HIV-1. Furthermore, the effects of Tat have been addressed in numerous studies to investigate the molecular events associated with neuronal cells survival and death. Here, we discovered that exposure of rat primary neurons to Tat resulted in the up-regulation of an uncharacterized long non-coding RNA (lncRNA), LOC102549805 (lncRNA-U1). Our observations showed that increased expression of lncRNA-U1 in neurons disrupts bioenergetic pathways by dysregulating homeostasis of Ca2+, mitigating mitochondrial oxygen reduction, and decreasing ATP production, all of which point mitochondrial impairment in neurons via the Tat-mediated lncRNA-U1 induction. These changes were associated with imbalances in autophagy and apoptosis pathways. Additionally, this study showed the ability of Tat to modulate expression of the neuropeptide B/W receptor 1 (NPBWR1) gene via up-regulation of lncRNA-U1. Collectively, our results identified Tat-mediated lncRNA-U1 upregulation resulting in disruption of neuronal homeostasis.