bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis
Authors: Tang Cheng , Chen Erbao , Peng Ke , Wang Haiwei , Cheng Xi , Wang Yan , Yu Shan , Yu Yiyi , Cui Yuehong , Liu Tianshu 
Published: May 2020

AbstractBackgroundThe indistinctive effects of antiangiogenesis agents in gastric cancer (GC) can be attributed to multifaceted gene dysregulation associated with angiogenesis. Angiopoietin‐like (ANGPTL) proteins are secreted proteins regulating angiogenesis. They are also involved in inflammation and metabolism. Emerging evidences have revealed their various roles in carcinogenesis and metastasis development. However, the mRNA expression profiles, prognostic values, and biological functions of ANGPTL proteins in GC are still elucidated.MethodsWe compared the transcriptional expression levels of ANGPTL proteins between GC and normal gastric tissues using ONCOMINE and TCGA‐STAD. The prognostic values were evaluated by LinkedOmics and Kaplan–Meier Plotter, while the association of expression levels with clinicopathological features was generated through cBioPortal. We conducted the functional enrichment analysis with Metascape.ResultsThe expression of ANGPTL1/3/6 was lower in GC tissues than in normal gastric tissues. High expression of ANGPTL1/2/4 was correlated with short overall survival and post‐progression survival in GC patients. Upregulated ANGPTL1/2 was correlated with higher histological grade, non‐intestinal Lauren classification, and advanced T stage, while ANGPTL4 exhibited high expression in early T stage, M1 stage, and non‐intestinal Lauren classification.ConclusionsIntegrative bioinformatics analysis suggests that ANGPTL1/2/4 may be potential therapeutic targets in GC patients. Among them, ANGPTL2 acts as a GC promoter, while ANGPTL1/4’s role in GC is still uncertain.
Plumbagin‐Serum Albumin Interaction: Spectral, Electrochemical, Structure‐Binding Analysis, Antiproliferative and Cell Signaling Aspects with Implications for Anticancer Therapy
Authors: Chrastina Adrian , Welsh John , Rondeau Gaelle , Abedinpour Parisa , Borgström Per , Baron Véronique T. 
Published: May 2020

AbstractPlumbagin (5‐hydroxy‐2‐methyl‐1,4‐naphthoquinone) is a small molecule with potent anticancer activity. Like other 1,4‐naphthoquinones, it exhibits electrophilic reactivity towards biological nucleophiles. We demonstrate that plumbagin and structurally related 1,4‐naphthoquinones with at least one unsubstituted quinoid carbon (C2 or C3) bind to albumin, an ubiquitously present nucleophile, with minimum recovery of free drug. Extraction recovery of plumbagin from albumin in solution showed one‐phase exponential decline with a half‐live of 9.3 min at 10 μmol/L. In the presence of albumin, plumbagin exhibited instant changes in UV/Vis absorption bands. Electrochemical analysis using cyclic voltammetry showed a decrease in redox peak currents over time until electro‐inactivity, thus suggesting the formation of a supramolecular adduct inaccessible for electron transfer. The adduct inhibited cell growth and caused cell‐cycle arrest of prostate cancer cells, in part by decreasing levels of the cell‐cycle regulator RBBP. The conjugate displayed similar cellular effects to those described for plumbagin, such as decreased levels of androgen receptor and protein kinase C epsilon. The effect of plumbagin‐albumin on cancer cells was species‐specific, suggesting a receptor‐mediated mechanism. Furthermore, it was blocked by cathepsin inhibitor pepstatin A, indicating that lysosomal degradation is involved in the processing of plumbagin‐albumin adduct. The spontaneously formed adduct of plumbagin with serum albumin is likely to mediate the biological activities of plumbagin in vivo and to fundamentally influence its pharmacodynamics.
Lithium‐Ion‐Based Electrochemical Energy Storage in a Layered Vanadium Formate Coordination Polymer
Authors: Anjana P. K. , Babu Binson , Shaijumon M. M. , Thirumurugan A. 
Published: May 2020

AbstractA vanadium formate (VF) coordination polymer and its composite with partially reduced graphene oxide (prGO), namely VF‐prGO, can be applied as anode materials for Li‐ion based electrochemical energy storage (EcES) systems in the potential range of 0–3 V (vs Li+/Li). This study shows that a reversible capacity of 329 mAh g−1 at a current density of 50 mA g−1 after 50 cycles can be realized for VF along with a high rate capability. The composite exhibits even a higher capacity of 504 mAh g−1 at 50 mA g−1. A good capacity retention is observed even after 140 cycles for both VF and the composite. An ex‐situ X‐ray photoelectron spectroscopy study indicates the involvement of V3+/V4+ redox couple in the charge storage mechanism. A significant contribution of this reversible capacity is attributed to the pseudocapacitive behavior of the system.
Doxorubicin‐Conjugated Iron Oxide Nanoparticles: Surface Engineering and Biomedical Investigation
Authors: Oleksa Viktoriia , Macková Hana , Patsula Vitalii , Dydowiczová Aneta , Janoušková Olga , Horák Daniel 
Published: May 2020

AbstractDevelopment of therapeutic systems to treat glioblastoma, the most common and aggressive brain tumor, belongs to priority tasks in cancer research. We have synthesized colloidally stable magnetic nanoparticles (Dh=336 nm) coated with doxorubicin (Dox) conjugated copolymers of N,N‐dimethylacrylamide and either N‐acryloylglycine methyl ester or N‐acryloylmethyl 6‐aminohexanoate. The terminal carboxyl groups of the copolymers were reacted with alendronate by carbodiimide formation. Methyl ester groups were then transferred to hydrazides for binding Dox by a hydrolytically labile hydrazone bond. The polymers were subsequently bound on the magnetic nanoparticles through bisphosphonate terminal groups. Finally, the anticancer effect of the Dox‐conjugated particles was investigated using the U‐87 glioblastoma cell line in terms of particle internalization and cell viability, which decreased to almost zero at a concentration of 100 μg of particles per ml. These results confirmed that poly(N,N‐dimethylacrylamide)‐coated magnetic nanoparticles can serve as a solid support for Dox delivery to glioblastoma cells.
Simple and Sustainable Preparation of Nonactivated Porous Carbon from Brewing Waste for High‐Performance Lithium–Sulfur Batteries
Authors: Tesio Alvaro Y. , Gómez‐Cámer Juan Luis , Morales Julián , Caballero Alvaro 
Published: May 2020

AbstractThe development of renewable energy sources requires the parallel development of sustainable energy storage systems because of its noncontinuous production. Even the most‐used battery on the planet, the lithium‐ion battery, is reaching its technological limit. In light of this, lithium–sulfur batteries have emerged as one of the most promising technologies to address this problem. The use of biomass to produce cathodes for these batteries addresses not only the aforementioned problem, but it also reduces the carbon footprint and gives added value to something normally considered waste. Here, the production, by simple and nonactivating pyrolysis, of a carbon material using the abundant “after‐boiling waste” derived from beer brewing is reported. After adding a high sulfur loading (70 %) to this biowaste‐derived carbon by the “melt diffusion” method, the sulfur–carbon composite is used as an effective cathode in Li–S batteries. The cathode shows excellent performance, reaching high capacity values with long‐term cyclability at high current—847 mAh g−1 at 1 C, 586 mAh g−1 at 2 C, and even 498 mAh g−1 at 5 C after 400 cycles—drastically reducing capacity loss to values approaching 0.01 % per cycle. This work demonstrates the possibility of obtaining low‐cost, highly sustainable cathodic materials for the design of advanced energy storage systems.
Facile Preparation of 3‐Acetamido‐5‐acetylfuran from N‐Acetyl‐d‐glucosamine by using Commercially Available Aluminum Salts
Authors: Padovan Daniele , Kobayashi Hirokazu , Fukuoka Atsushi 
Published: May 2020

Abstract3‐Acetamido‐5‐acetylfuran (3A5AF) is a promising intermediate obtained from chitin for the production of N‐containing value‐added chemicals. However, the synthetic method is complicated so far, which has limited further investigation using 3A5AF. Herein, a facile method was developed for synthesizing 3A5AF from N‐acetyl‐d‐glucosamine (NAG), including a simple isolation procedure. A 30 % yield of 3A5AF was obtained by performing the dehydration of NAG in N,N‐dimethylformamide (DMF) solvent in the presence of AlCl3⋅6 H2O at a temperature as low as 120 °C by conventional heating for 30 min. This method tolerated a wide range of temperature and concentration of substrate, thus easily allowing scale‐up of the reaction. The produced 3A5AF was isolated with 98 % purity by simple column chromatography. Additionally, a highly functionalized N‐containing lactone was identified as a byproduct under these reaction conditions.
Postrelease movement and habitat selection of translocated pine martensMartes martes
Authors: McNicol Catherine M. , Bavin David , Bearhop Stuart , Bridges Josie , Croose Elizabeth , Gill Robin , Goodwin Cecily E. D. , Lewis John , MacPherson Jenny , Padfield Daniel , Schofield Henry , Silk Matthew J. , Tomlinson Alexandra J. , McDonald Robbie A. 
Published: May 2020

AbstractMonitoring postrelease establishment and movement of animals is important in evaluating conservation translocations. We translocated 39 wild pine martensMartes martes(19 females, 20 males) from Scotland to Wales. We released them into forested areas with no conspecifics in 2015, followed by a second release in 2016, alongside the previously released animals. We used radio‐tracking to describe postrelease movement and habitat selection. Six martens (15%) were not re‐encountered during the tracking period, of which four undertook long‐distance dispersal. For the remaining individuals, we characterized two phases of movement, “exploration” followed by “settlement,” that differed between releases. In the first release, martens remained in exploration phase for a mean of 14.5 days (SE = 3.9 days) and settled at a mean distance of 8.7 km (SE = 1.8 km) from release sites, whereas martens released in year two, alongside resident conspecifics, traveled away from release sites at a faster rate, settling sooner, at a mean of 6.6 days (SE = 1.8 days), but further, at a mean distance of 14.0 km (SE = 1.7 km) from release sites. Animals released in year one did not exhibit habitat preferences overall but within forests they favored recently felled areas, whereas animals released in year two showed strong selection for forested habitat but did not discriminate between forest types. The presence of conspecifics appeared influential for settlement and site fidelity of translocated martens and was associated with more rapid but more distant dispersal of the later cohort. Releases of animals in close proximity appeared to promote site fidelity and rapid establishment of ranges in the recipient environment.
Circulating protein biomarkers predict incident hypertensive heart failure independently of N‐terminal pro‐B‐type natriuretic peptide levels
Authors: Fernandez Celine , Rysä Jaana , Ström Kristoffer , Nilsson Jan , Engström Gunnar , Orho‐Melander Marju , Ruskoaho Heikki , Melander Olle 
Published: May 2020

AbstractAimsHypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch‐induced circulating biomarkers for predicting hypertension‐associated HF.Methods and resultsCirculating levels of 149 proteins were measured by proximity extension assay at baseline examination in 4742 individuals from the Malmö Diet and Cancer study. Protein levels were compared with stretch‐activated gene expression changes in cultured neonatal rat ventricular myocytes (NRVMs) in response to 1–48 h of mechanical stretch. We also studied the association between protein levels and hypertension and HF incidence using respectively binary logistic and Cox regressions. Levels of 35 proteins were differentially expressed after Bonferroni correction in incident HF vs. control (P < 3.4E−4). Growth differentiation factor‐15 (GDF‐15), interleukin‐6 (IL‐6), IL‐1 receptor type 1, and urokinase plasminogen activator surface receptor had corresponding mRNA levels up‐regulated by stretch in NRVMs at all time points (P < 0.05). These four proteins were individually associated with increased risk of HF after age and sex adjustment [hazard ratio (HR) per standard deviation: 1.19 ≤ HR ≤ 1.49, P ≤ 4.90E−3]. GDF‐15 and IL‐6 were associated with HF independently of each other (1.22 ≤ HR ≤ 1.33, P ≤ 0.001). In subjects with hypertension, these associations remained significant after further adjustment for N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels (1.23 ≤ HR ≤ 1.45, P ≤ 0.001). A higher fasting value of a GDF‐15, IL‐6 score aggregate was associated with increased risk of hypertensive HF after adjustment for all traditional risk factors for HF and NT‐proBNP (HR = 1.31, P = 2.19E−4).ConclusionsCardiomyocyte mRNA levels of GDF‐15 and IL‐6 are consistently up‐regulated by stretch, and their circulating protein levels predict HF in hypertensive subjects independently of NT‐proBNP during long‐term follow‐up. Our results encourage further studies on lower blood pressure goals in hypertensive subjects with high GDF‐15 and IL‐6, and interventions targeted at stretch‐induced cardiomyocyte expressed biomarkers.
On the use of the coefficient of variation to quantify and compare trait variation
Authors: Pélabon Christophe , Hilde Christoffer H. , Einum Sigurd , Gamelon Marlène 
Published: May 2020

AbstractMeaningful comparison of variation in quantitative trait requires controlling for both the dimension of the varying entity and the dimension of the factor generating variation. Although the coefficient of variation (CV; standard deviation divided by the mean) is often used to measure and compare variation of quantitative traits, it only accounts for the dimension of the former, and its use for comparing variation may sometimes be inappropriate. Here, we discuss the use of the CV to compare measures of evolvability and phenotypic plasticity, two variational properties of quantitative traits. Using a dimensional analysis, we show that contrary to evolvability, phenotypic plasticity cannot be meaningfully compared across traits and environments by mean-scaling trait variation. We further emphasize the need of remaining cognizant of the dimensions of the traits and the relationship between mean and standard deviation when comparing CVs, even when the scales on which traits are expressed allow meaningful calculation of the CV.
Growth and capacity for cost‐effectiveness analysis in Africa
Authors: Panzer Ari D. , Emerson Joanna G. , D'Cruz Brittany , Patel Avnee , Dabak Saudamini , Isaranuwatchai Wanrudee , Teerawattananon Yot , Ollendorf Daniel A. , Neumann Peter J. , Kim David D. 
Published: May 2020

AbstractAs economic evaluation becomes increasingly essential to support universal health coverage (UHC), we aim to understand the growth, characteristics, and quality of cost‐effectiveness analyses (CEA) conducted for Africa and to assess institutional capacity and relationship patterns among authors. We searched the Tufts Medical Center CEA Registries and four databases to identify CEAs for Africa. After extracting relevant information, we examined study characteristics, cost‐effectiveness ratios, individual and institutional contribution to the literature, and network dyads at the author, institution, and country levels. The 358 identified CEAs for Africa primarily focused on sub‐Saharan Africa (96%) and interventions for communicable diseases (77%). Of 2,121 intervention‐specific ratios, 8% were deemed cost‐saving, and most evaluated immunizations strategies. As 64% of studies included at least one African author, we observed widespread collaboration among international researchers and institutions. However, only 23% of first authors were affiliated with African institutions. The top producers of CEAs among African institutions are more adherent to methodological and reporting guidelines. Although economic evidence in Africa has grown substantially, the capacity for generating such evidence remains limited. Increasing the ability of regional institutions to produce high‐quality evidence and facilitate knowledge transfer among African institutions has the potential to inform prioritization decisions for designing UHC.
Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells
Authors: Li Manman , Xue Yang , Yu Hao , Mao Dagan 
Published: May 2020

AbstractQuercetin (Que) is a natural flavonoid in most plants. Luteinized granulosa cell (LGC) culture is necessary for the study of follicle growth/differentiation. In the present study, we analyzed the role of Que in steroid production and apoptosis in hydrogen peroxide (H2O2)‐treated goat LGCs. The results showed that treatment with H2O2 induced apoptosis in goat LGCs, and treatment with Que decreased LGC apoptosis induced by H2O2 (P < .05), accompanied with the different expressions of BAX, BCL‐2, Caspase 3, and Cleaved caspase 3. Meanwhile, the messenger RNA expressions of nuclear factor erythroid 2 like 2 (Nrf2) and its downstream genes were upregulated with H2O2 +Que treatment, accompanied by the increased cellular viability (P < .05). Furthermore, Que alleviated H2O2‐induced reduction in the secretion of progesterone (P4) (P < .05); however, it had no effect on the secretion of estrogen (E2). Simultaneously, the expressions of StAR and P450scc were increased when treated with Que +H2O2, compared with the group treated with only H2O2 (P < .05). In conclusion, it is observed that Que could alleviate the H2O2‐induced apoptosis and steroidogenic impairment in goat LGCs, which might be mediated by the Nrf2 pathway.
Measuring therapists' attitudes toward integration of technology in psychotherapy and predicting their use of technology
Authors: Bagarić Branka , Jokić‐Begić Nataša 
Published: May 2020

AbstractObjectivesWe aimed to develop a measure of psychotherapists' attitudes toward integrating technology in psychotherapy—The Therapists' Attitudes toward using Modern Technologies in Psychotherapy and Counselling Scale (MTPS), to analyze its latent structure and test its reliability and validity.MethodItems were developed based on interviews with psychotherapists, followed by two online surveys with psychotherapists (N1 = 219; N2 = 369) in five countries in South‐eastern Europe.ResultsThe MTPS has a 4‐factor structure: perceived potential of modern technologies (MTs) to augment therapeutic improvement, perceived psychoeducational value of MTs, perceived risks associated with using MTs, and perceived relevance of MTs. Specific dimensions of the MTPS predicted psychotherapists' behaviors and intentions regarding technology (Rc = 0.15–0.46). The reliability of the MTPS subscales was satisfactory.ConclusionMTPS appears to be a useful instrument. Exploring psychotherapists' attitudes assists in predicting obstacles to the implementation of technology in psychotherapy and planning adequate intervention to overcome it.
Mental health and sleep disparities in an urban college sample: A longitudinal examination of White and Black students
Authors: Dzierzewski Joseph M. , Ravyts Scott G. , Dautovich Natalie D. , Perez Elliottnell , Schreiber Dana , Rybarczyk Bruce D. 
Published: May 2020

AbstractObjectiveRacial disparities in sleep may be consequential among college students given high rates of dysfunctional sleep among this population. The present study sought to investigate whether disparities in sleep explain existing mental health disparities.MethodData included secondary analysis of a college risk behaviors and health study (n = 1242, mean age = 18.5). Race was dichotomized as White or Black, excluding all others, with participants completing measures of sleep at baseline and measures of depression and anxiety at follow‐up 1 to 2 years later.ResultsCompared to White students, Black students were more likely to report lower rates of depression and anxiety, but poorer sleep outcomes. Mediation analyses revealed that sleep partially mediated (suppressed) the association between race and depressive and anxiety symptoms.ConclusionsResults indicate that disparities in sleep may play an important role in the association between race and mental health symptoms among college students. Future health disparity research would benefit from exploring the potentially bidirectional relationship between sleep and mental health symptoms among college students.
An exploration of relationship between self‐compassion and voice‐related distress in people who hear voices
Authors: Norman Debbie , Correia Helen , Paulik Georgie 
Published: May 2020

AbstractObjectiveThe cognitive behavior model of voice hearing suggests individuals who have lower self‐esteem, perceive themselves to be of low social rank, and hold negative beliefs about their voices, are more distressed by their voices. Self‐compassion may help reduce voice‐related distress through the activation of positive self and social mentalities. The aim of the present study was to examine the role of self‐compassion in variables within the cognitive behavior model.MethodMeasures assessing self‐compassion, negative affect, self‐esteem, voice malevolence, omnipotence, and distress were administered to a sample of clinical voice hearers (N = 53).ResultsCorrelation and mediation analyses were conducted. Higher self‐compassion was associated with lower negative affect, voice malevolence, omnipotence, and distress. Voice malevolence was found to mediate the relationship between self‐compassion and voice distress. Self‐compassion was a stronger predictor of these constructs than self‐esteem.ConclusionImproving self‐compassion may have significant clinical benefits in reducing voice‐related distress.
Prosthetic valve endocarditis presenting with back pain alone: A case report
Authors: Sato Toshihiro , Morioka Shinichiro , Nakamoto Takato , Nakamura Keiji , Irisawa Yusuke , Horai Tetsuya , Ohmagari Norio 
Published: May 2020

AbstractWe report a case of a 64‐year‐old woman with a past medical history (PMH) of prosthetic valve replacement 7 months prior to admission, who presented with only right back pain. Physical examination revealed one conjunctival spot hemorrhage and a mild systolic murmur. Blood cultures were positive for methicillin‐resistant Staphylococcus epidermidis. Trans‐esophageal echocardiography revealed aortic valve vegetations; hence, a diagnosis of prosthetic valve endocarditis (PVE) was made. Clinical presentation of infective endocarditis varies and sometimes mimics that of polymyalgia rheumatica. The patient was diagnosed as PVE considering the whole clinical picture including the patient's PMH, physical examination, and blood cultures.