bluuebunny/crossref_metadata_2025_split huggingface dataset:
The unmet needs of patients with sarcoma
Authors: Weaver Rhys , O'Connor Moira , Sobhi Salar , Carey Smith Richard , Halkett Georgia 
Published: May 2020

AbstractObjectiveSarcoma is a rare cancer that imposes a significant burden on the lives of patients. Many survivors have long‐term disability as a result of treatment and the disease. Patients often experience functional issues, poorer mental health, reduced quality of life, and interpersonal issues. There is a need to explore the unmet needs of sarcoma patients as it is unclear how these issues are being addressed. The aim of this study was to explore the unmet needs of patients who have been diagnosed with sarcoma.MethodsThe participants were individuals previously diagnosed with a sarcoma (n = 22). Participants completed a semi‐structured interview about their unmet needs relating to sarcoma. The transcripts were analyzed using thematic analysis.ResultsFive overarching themes were identified: daily living, financial needs, lack of information, need for a community, and navigating the healthcare system. Participants reported a range of practical needs, including transport, limited understanding of their treatments, and financial issues. Participants also described a need to connect with people who had gone through similar experiences.ConclusionsSarcoma patients have fundamental needs that affect their capacity to live their life in the best possible way. Health services need to better facilitate sarcoma patients at each stage of their experience by providing individualized referrals, support, and coordination. Support interventions are needed to help patients adjust to sarcoma and to improve their quality of life as an outpatient. Connecting patients with sarcoma support groups may provide them with more relevant and intimate support.
Age‐stratified validation of the functional assessment of chronic illness therapy‐spiritual well‐being based on a large cohort of Danish cancer survivors
Authors: Kørup Alex K. , Wehberg Sonja , Hvidt Elisabeth A. , Hvidt Niels Christian , Fitchett George , Hansen Dorte Gilså 
Published: May 2020

AbstractObjectivePrevious research indicates that the FACIT‐Sp instrument is susceptible to bias when measuring spiritual well‐being in older patients. Our first focus was to evaluate the two‐factor vs the three‐factor model of the FACIT‐Sp and our second focus was to explore how these models behave for different age groups.MethodsWe used a large national cohort of Danish cancer patients (N = 3439) which included a significant number of patients aged at least 70 years (N = 1033). Item‐test correlations and factor analyses were conducted on complete cases (N = 2820). Additionally, a reliability analysis was performed using Cronbach's alpha and Guttman's lower‐bound estimate.ResultsFactor analysis revealed a loading pattern for the oldest age group (70+) showing items on peace and meaning loading into a single factor, as originally proposed in the two‐factor model. The loading estimates for the patients younger than 70 matched the three‐factor model. Furthermore, item‐test correlations changed as age increased. Based on Cronbach's alpha and Guttman's estimate of .83 and .89, respectively, total scores proved reliable. Items 4, 8, and 12 are discussed separately concerning their problematic influence on instrument validity in their current formulation.ConclusionOverall, the three‐factor model had a good fit; however, for the eldest patients a two‐factor solution proved even better. Interpretation of FACIT‐Sp subscale scores of older cancer patients must therefore be done with caution.
Inheritance of Bacillus thuringiensis Cry2Ab2 protein resistance in Helicoverpa zea (Lepidoptera: Noctuidae)
Authors: Yang Fei , Head Graham P , Price Paula A , Santiago González José C , Kerns David L 
Published: May 2020

AbstractBACKGROUNDThe corn earworm, Helicoverpa zea (Boddie), is a major target pest of pyramided Bt corn and cotton in the United States. Field‐evolved practical resistance to Cry1 and Cry2 proteins in H. zea has been documented in multiple locations in the United States. Understanding the genetic basis of Bt resistance is essential in developing insect resistance management (IRM) strategies for the sustainable use of the Bt crop technology. In this study, we characterized the genetic bases of Cry2Ab2 resistance in H. zea using diet‐overlay bioassays with two different forms of Cry2Ab2 protein.RESULTSLaboratory bioassays using a Cry2Ab2‐resistant (RR) strain, a susceptible (SS) strain, as well as cross and backcross strains, revealed that resistance to Cry2Ab2 was autosomally inherited and controlled by more than one locus. In diet bioassays, the dominance of Cry2Ab2 resistance in H. zea varied from incompletely recessive to incompletely dominant across all tested Cry2Ab2 concentrations of either Bt corn leaf powder or solubilized protein. On leaf tissue of TwinLink cotton (expressing Cry1Ab and Cry2Ae), Cry2Ab2 resistance in H. zea was completely dominant.CONCLUSIONThese results have significant implications for understanding the widespread field‐evolved resistance of H. zea against Cry1 and Cry2 proteins in Bt corn and cotton and should be useful in developing effective IRM strategies for H. zea. © 2020 Society of Chemical Industry
First case of glyphosate resistance in weedy sunflower (Helianthus annuus)
Authors: Singh Vijay , Etheredge Luke , McGinty Josh , Morgan Gaylon , Bagavathiannan Muthukumar 
Published: May 2020

AbstractBACKGROUNDWeedy sunflower (Helianthus annuus L.) is a troublesome weed in row‐crop production fields in South Texas. Populations with suspected resistance to glyphosate were evaluated with 1X and 4X rates (X = 868 g ae ha−1) of the herbicide, followed by a dose–response assay of the most resistant population. Molecular studies were conducted to determine if target‐site mechanisms were responsible for resistance in these populations. Additionally, field experiments were conducted at two locations (Somerville and Granger, TX) to evaluate the effectiveness of different tank‐mix combinations in controlling naturally infesting glyphosate‐resistant (GR) weedy sunflower populations in GR corn.RESULTSIn a study conducted in the growth chamber, seven of the 11 tested populations survived up to the 4X rate of glyphosate. The most‐resistant population (TX15‐11) was 29‐fold more resistant to glyphosate, compared to the susceptible standard. In resistant populations, 5–21 more copies of the EPSPS gene were observed compared to the susceptible standard. In the field studies, tank‐mix applications of glyphosate + halosulfuron‐methyl, glyphosate + prosulfuron, glyphosate + a premix of halosulfuron‐methyl and dicamba or glyphosate + a premix of diflufenzopyr and dicamba effectively controlled GR weedy sunflower populations.CONCLUSIONGlyphosate‐resistance was observed in 81% of the putative resistant weedy sunflower populations tested in this study. Resistance in these populations was conferred primarily by amplification of the EPSPS gene. Effective control of GR weedy sunflower can be achieved by tank‐mixes tested in the current study, which provides acceptable levels of crop safety. © 2020 Society of Chemical Industry
A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia
Authors: Tak Young Jin , Lee Sang Yeoup , Cho A Ra , Kim Young Sil 
Published: May 2020

Abstract
Accumulating evidence suggests that adipose-derived stem cell constituent extract (ADSC-CE) helps hair regrowth in patients with androgenetic alopecia (AGA). However, the effects of ADSC-CE have not been demonstrated in a randomized, double-blind, vehicle-controlled clinical trial. In this randomized, double-blind, vehicle-controlled clinical trial, 38 patients (29 men) with AGA were assigned to an intervention group (IG), with twice-daily self-application of the ADSC-CE topical solution over the scalp with fingers, or to a control group (CG). Changes in hair count and thickness at 16 weeks from the baseline were evaluated using a phototrichogram. Overall, 34 (89%) patients (mean age, 45.3 years) completed the study. The phototrichogram at week 8 showed more increase in hair count in the IG than in the CG, and intergroup differences in the change of hair count remained significant until week 16 with overall changes of 28.1% vs 7.1%, respectively. Similarly, a significant improvement in hair diameter was observed in the IG (14.2%) after 16 weeks when compared with hair diameter in the CG (6.3%). Our findings suggest that the application of the ADSC-CE topical solution has enormous potential as an alternative therapeutic strategy for hair regrowth in patients with AGA, by increasing both hair density and thickness while maintaining adequate treatment safety.

Significance statement This study suggests the application of adipose-derived stem cell constituent extract topical solution has the potential as an alternative therapeutic strategy for hair regrowth in patients with androgenetic alopecia by increasing both hair density and thickness while maintaining adequate treatment safety.
Electricity Enhancement by MFCs from Food Waste Ethanol Fermentation Recycle Stillage Effect of Dilution Ratio and Addition of Tween 80
Authors: Gao Ming , Li Huiyu , Ma Hongzhi , Peng Cheng , Wu Wenyu , Yu Ziqiang , Wang Qunhui 
Published: May 2020

AbstractThe ethanol fermentation stillage of food waste can be used as the substrate of microbial fuel cells (MFCs), but its complexity affected the electricity production. In this study, the effect of the dilution ratio and the addition of Tween 80 on MFCs were carried out. The results showed that the maximum output power based on the cathode area and volume gradually enhanced with the increase of the dilution ratio, and the maximum output power of 612 mW m−2 and 6.4 W m−3 reached with the dilution of 200 times. The removal rate of organic acids by MFCs remained stable between 58 % and 62 %. The maximum output power of MFCs with three kinds of Tween 80 concentrations, 5 mg L−1, 20 mg L−1 and 80 mg L−1, increased by 2.1 times, 3.1 times and 1.4 times respectively. The addition of Tween 80 can significantly reduce the biotoxicity. With 20 mg L−1 Tween 80 added, the toxicity removal rate reached highest of 95.1 %.
Copper‐Catalyzed sp3‐Carbon Radical/Halogen Radical Cross Coupling: Selective Halogenation of 1,3‐Dicarbonyl Compounds
Authors: Lv Shuai‐Shuai , Yan Xu‐Ping , Li Cheng‐Kun , Zhou Shao‐Fang , Shoberu Adedamola , Zou Jian‐Ping 
Published: May 2020

AbstractA new copper‐catalyzed sp3‐carbon radical/halogen radical cross‐coupling strategy for the formation of C(sp3)‐X bond is described. This provides a general method for synthesis of α‐halogenated and α,α‐dihalogenated‐1,3‐dicarbonyl compounds using sodium halides as halogen source under mild conditions.
Increases of negative affect following daily hassles are not moderated by neuroticism: An ecological momentary assessment study
Authors: Mey Lara Kristin , Chmitorz Andrea , Kurth Karolina , Wenzel Mario , Kalisch Raffael , Tüscher Oliver , Kubiak Thomas 
Published: May 2020

AbstractThe occurrence of daily hassles is associated with increased subsequent levels of negative affect. Neuroticism has been found to exacerbate this effect. So far, most research used single‐item measures for the assessment of daily hassles or relied on daily diary studies. This study aimed to examine the interrelations of daily hassles, negative affect reactivity, and neuroticism in daily life employing an extensive inventory of daily hassles. Seventy participants (18–30 years; M = 23.9 years, 59% female) completed a 4‐week smartphone‐based ecological momentary assessment study reporting the occurrence and perceived strain of daily hassles as well as negative affect at five semi‐random signals between 9 a.m. and 8 p.m. Multilevel analyses revealed significant associations between elevated levels of negative affect and higher cumulative daily hassle strain ratings per signal in concurrent and time‐lagged analyses. Contrary to our expectations, there was no moderation by neuroticism on these associations. The results suggest that daily hassles can accumulate in their impact on mood in daily life and exert a prolonged effect on negative affect. The absence of a significant moderation by neuroticism may be interpreted in the light of methodological specifics of this study.
Turning Waste into Treasure: Regulating the Oxygen Corrosion on Fe Foam for Efficient Electrocatalysis
Authors: Liu Xupo , Gong Mingxing , Xiao Dongdong , Deng Shaofeng , Liang Jianing , Zhao Tonghui , Lu Yun , Shen Tao , Zhang Jian , Wang Deli 
Published: May 2020

AbstractIron corrosion causes a great damage to the economy due to the function attenuation of iron‐based devices. However, the corrosion products can be used as active materials for some electrocatalytic reactions, such as oxygen evolution reaction (OER). Herein, the oxygen corrosion on Fe foams (FF) to synthesize effective self‐supporting electrocatalysts for OER, leading to “turning waste into treasure,” is regulated. A dual chloride aqueous system of “NaCl‐NiCl2” is employed to tailor the structures and OER properties of corrosion layers. The corrosion behaviors identify that Cl− anions serve as accelerators for oxygen corrosion, while Ni2+ cations guarantee the uniform growth of corrosion layers owing to the appeared chemical plating. The synergistic effect of “NaCl‐NiCl2” generates one of the highest OER activities that only an overpotential of 212 mV is required to achieve 100 mA cm−2 in 1.0 m KOH solution. The as‐prepared catalyst also exhibits excellent durability over 168 h (one week) at 100 mA cm−2 and promising application for overall water splitting. Specially, a large self‐supporting electrode (9 × 10 cm2) is successfully synthesized via this cost‐effective and easily scale‐up approach. By combining with corrosion science, this work provides a significant stepping stone in exploring high‐performance OER electrocatalysts.
Chiral Ligand‐Free, Optically Active Nanoparticles Inherently Composed of Chiral Lattices at the Atomic Scale
Authors: Yang Lin , Liu Junjun , Sun Peng , Ni Ziyue , Ma Yicong , Huang Zhifeng 
Published: May 2020

AbstractBulk metals lack chirality. Recently, metals have been sculptured with metastable chirality varying from the micro‐ to nano‐scale. The manipulation of molecular chirality could be novelly performed using metals composed of chiral lattices at atomic scales (i.e., chiral nanoparticles or CNPs) if one could fundamentally understand the interactions between molecules and the chiral metal lattices. The incorporation of chiral ligands has been generally adapted to form metal CNPs. However, post‐fabrication removal of chiral ligands usually causes relaxation of the metastable chiral lattices to thermodynamically stable achiral structures, and thus the coexisting chiral ligands will unavoidably disturb or screen the interactions of interest. Herein, a concept of metal CNPs that are free of chiral ligands and consist of atomically chiral lattices is introduced. Without chiral ligands, shear forces applied by substrate rotation along with the translation of incident atoms lead to imposing the metastable chiral lattices onto metals. Metal CNPs show not only the chiroptical effect but the enantiospecific interactions of chiral lattices and molecules. These two unique chiral effects have resulted in the applications of enantiodifferentiation and asymmetric synthesis. Prospectively, the extension in composition space and constituent engineering will apply alloy CNPs to enantiodiscrimination, enantioseperation, bio‐imaging, bio‐sensing, and asymmetric catalysis.
Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP‐Mediated Mechanosensing
Authors: Bandaru Praveen , Cefaloni Giorgia , Vajhadin Fereshteh , Lee KangJu , Kim Han‐Jun , Cho Hyun‐Jong , Hartel Martin C. , Zhang Shiming , Sun Wujin , Goudie Marcus J. , Ahadian Samad , Dokmeci Mehmet Remzi , Lee Junmin , Khademhosseini Ali 
Published: May 2020

AbstractStem cells secrete trophic factors that induce angiogenesis. These soluble factors are promising candidates for stem cell–based therapies, especially for cardiovascular diseases. Mechanical stimuli and biophysical factors presented in the stem cell microenvironment play important roles in guiding their behaviors. However, the complex interplay and precise role of these cues in directing pro‐angiogenic signaling remain unclear. Here, a platform is designed using gelatin methacryloyl hydrogels with tunable rigidity and a dynamic mechanical compression bioreactor to evaluate the influence of matrix rigidity and mechanical stimuli on the secretion of pro‐angiogenic factors from human mesenchymal stem cells (hMSCs). Cells cultured in matrices mimicking mechanical elasticity of bone tissues in vivo show elevated secretion of vascular endothelial growth factor (VEGF), one of representative signaling proteins promoting angiogenesis, as well as increased vascularization of human umbilical vein endothelial cells (HUVECs) with a supplement of conditioned media from hMSCs cultured across different conditions. When hMSCs are cultured in matrices stimulated with a range of cyclic compressions, increased VEGF secretion is observed with increasing mechanical strains, which is also in line with the enhanced tubulogenesis of HUVECs. Moreover, it is demonstrated that matrix stiffness and cyclic compression modulate secretion of pro‐angiogenic molecules from hMSCs through yes‐associated protein activity.
A More Efficient Fenton Oxidation Method with High Shear Mixing for the Preparation of Cellulose Nanofibers
Authors: Duan Linjuan , Liu Rongrong , Li Qun 
Published: May 2020

AbstractA more efficient Fenton oxidation method with high shear mixing for the preparation of cellulose nanofiber (CNF) is investigated. The Fenton reaction is the reaction between Fe2+ and H2O2 to produce a series of free radicals that leads to oxidation of the cellulose. With the new technology, the Fe2+ is preloaded into the kraft pulp by a high shear refining method to realize in situ oxidation of cellulose fibers. It is found that the carbonyl content in the fibers using high shear mixing process is 149.79 μmol g−1 when the dosage of hydrogen peroxide is 0.08 g/g (weight of dry fibers), compared to the 126.40 μmol g−1 of fiber without high shearing when the dosage of hydrogen peroxide is 0.15 g/g, which indicates that the new Fe2+ pre‐loading process has higher oxidation efficiency with lower H2O2 consumption compared with traditional Fe2+ preloading process. The 13C NMR results show that the C2, C3, and C6 hydroxyl groups are oxidized to aldehyde and carboxyl groups, which is beneficial to increase the electrostatic repulsion between fibers and facilitate the subsequent homogenization treatment. The obtained CNF is uniform in size and slightly lower in thermal stability.
Long noncoding RNA H19 acts as a miR‐340‐3p sponge to promote epithelial‐mesenchymal transition by regulating YWHAZ expression in paclitaxel‐resistant breast cancer cells
Authors: Yan Lei , Yang Shuo , Yue Cheng‐Xu , Wei Xin‐Yu , Peng Wei , Dong Zheng‐Yuan , Xu He‐Nan , Chen Su‐Lian , Wang Wen‐Rui , Chen Chang‐Jie , Yang Qing‐Ling 
Published: May 2020

AbstractBreast cancer (BC) is the leading cause of cancer‐related death in women worldwide and one of the most prevalent malignancy. In recent years, increasing evidence had illuminated that long noncoding RNAs (lncRNAs) serve as critical factors in multiple tumor progression, including BC. Emerging references had indicated that the lncRNA H19 acts as significant roles in tumor progression and epithelial‐mesenchymal transition (EMT). However, the underlying molecular mechanisms and biological roles of H19 in BC invasion, metastasis and EMT are still unclear. In this study, it was detected that the expression level of H19 was increased in BC paclitaxel‐resistant (PR) cells subline (MCF‐7/PR) in comparison with MCF‐7 parental cells. In vitro, there were demonstrated that H19 overexpression promoted BC cells proliferation, metastasis, invasion and EMT procedures, and suppressed cells apoptosis. Whereas, H19 suppression resulted in the contrary biological effects. Besides, bioinformatics tools and dual‐luciferase reporters assays indicated that miR‐340‐3p could act as a potential target gene of H19, the underlying mechanism studies proved that H19 could act as a competing endogenous RNA (ceRNA) via competitively binding miR‐340‐3p to promote BC cell proliferation, metastasis and EMT by regulating tyrosine 3‐monooxygenase/tryptophan 5‐monooxygenase activation protein zeta (YWHAZ) and potentiate the Wnt/β‐catenin signaling in BC cells. In summary, our findings demonstrated that H19 could act as a ceRNA in BC progression, metastasis and EMT through modulating miR‐340‐3p/YWHAZ axis and activating the canonical Wnt/β‐catenin signaling pathway, indicating that H19 might act as an underlying therapeutic target and prognostic biomarker for BC therapy.
Nodular panniculitis in a cat with high alpha tocopherol concentration in serum
Authors: Steffl Martin , Nautscher Nadine , Kröpfl Alexander , Granvogl Michael 
Published: May 2020

AbstractA 5‐year‐old male neutered domestic shorthair cat suffered from recurrent solitary nodules in different subcutaneous body regions. Nodules were surgically removed and each time histopathological diagnosis was fat necrosis and fibrosing to pyogranulomatous panniculitis. After the second surgery the alpha (α)‐tocopherol concentration in serum of the cat was examined and the result (21 mg/L) exceeded the upper limit of the reference interval (3–11 mg/L). Vitamin E amount in diet fed solely in the past was checked as studies have shown that vitamin E amounts in food significantly influence vitamin E concentrations in serum. For comparative purposes, α‐tocopherol concentrations were determined in sera of healthy control cats. Additionally, vitamin E amount in wet food from different manufacturers was analysed using gas chromatography coupled to mass spectrometry (GC‐MS). The results showed that the diet did not have higher vitamin E amounts compared to other diets. All control cats had similar high serum α‐tocopherol concentrations. We conclude that panniculitis can occur despite high serum α‐tocopherol concentrations in cats. Further studies are needed to redefine reference values of α‐tocopherol in serum of cats.
Patientenregister für Seltene Erkrankungen in Deutschland: Konzeptpapier der Strategiegruppe „Register“ des Nationalen Aktionsbündnisses für Menschen mit Seltenen Erkrankungen (NAMSE)
Authors:   NAMSE-Register-Strategiegruppe, Storf Holger , Stausberg Jürgen , Kindle Gerhard , Quadder Bernd , Schlangen Miriam , Walter Maggie C. , Ückert Frank , Wagner Thomas O. F. 
Published: May 2020

ZusammenfassungDer Nationale Aktionsplan für Menschen mit Seltenen Erkrankungen (SE) enthält 52 konkrete Maßnahmen, u. a. in den Handlungsfeldern Versorgung, Forschung, Diagnose und Informationsmanagement. Mit dem Ziel, langfristig die Qualität und Interoperabilität von nationalen Registern zu erhöhen, sieht Maßnahmenvorschlag 28 die Etablierung einer Strategiegruppe „Register für Seltene Erkrankungen“ vor. Diese Strategiegruppe hat 2016 ihre Arbeit aufgenommen. Sie berichtet hier über Entwicklungen auf nationaler und internationaler Ebene, um Empfehlungen für nationale Initiativen daraus abzuleiten.Zusätzlich werden die Konsentierung und Implementierung sowie mit der Zeit ggf. die Anpassung eines Minimaldatensatzes zur Verwendung in Registern für Seltene Erkrankungen erläutert. Zusätzlich werden die verwendeten Datenelemente bzw. -schemata in einem sog. Metadata Repository abgebildet. Dieses Positionspapier wurde durch die Strategiegruppe sowie weitere Autoren erarbeitet und innerhalb der Gruppe konsentiert. Es wird als Konzeptpapier zum Aufbau und Betrieb von Registern der Strategiegruppe „Register“ veröffentlicht.