bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health system challenges for improved childhood pneumonia case management in Lagos and Jigawa, Nigeria
Authors: Shittu Funmilayo , Agwai Imaria C. , Falade Adegoke G. , Bakare Ayobami A. , Graham Hamish , Iuliano Agnese , Aranda Zeus , McCollum Eric D. , Isah Adamu , Bahiru Solomon , Ahmed Tahlil , Burgess Rochelle A. , King Carina , Colbourn Tim , on behalf of the INSPIRING Project Consortium  
Published: January 2020

AbstractBackgroundCase fatality rates for childhood pneumonia in Nigeria remain high. There is a clear need for improved case management of pneumonia, through the sustainable implementation of the Integrated Management of Childhood Illnesses (IMCI) diagnostic and treatment algorithms. We explored barriers and opportunities for improved case management of childhood pneumonia in Lagos and Jigawa states, Nigeria.MethodsA mixed‐method analysis was conducted to assess the current health system capacity to deliver quality care. This was done through audits of 16 facilities in Jigawa and 14 facilities in Lagos, questionnaires (n = 164) and 13 focus group discussions with providers. Field observations provided context for data analysis and triangulation.ResultsThere were more private providers in Lagos (4/8 secondary facilities) and more government providers in Jigawa (4/8 primary, 3/3 secondary, and 1/1 tertiary facilities). Oxygen and pulse oximeters were available in two of three in Jigawa and six of eight in Lagos of the sampled secondary care facilities. None of the eight primary facilities surveyed in Jigawa had oxygen or pulse oximetry available while in Lagos two of three primary facilities had oxygen and one of three had pulse oximeters. Other IMCI and emergency equipment were also lacking including respiratory rate timers, particularly in Jigawa state. Health care providers scored poorly on knowledge of IMCI, though previous IMCI training was associated with better knowledge. Key enabling factors in delivering pediatric care highlighted by health care providers included accountability procedures and feedback loops, the provision of free medication for children, and philanthropic acts. Common barriers to provide care included the burden of out‐of‐pocket payments, challenges in effective communication with caregivers, delayed presentation, and lack of clear diagnosis, and case management guidelines.ConclusionThere is an urgent need to improve how the prevention and treatment of pediatric pneumonia is directed in both Lagos and Jigawa. Priority areas for reducing pediatric pneumonia burden are training and mentoring of health care providers, community health education, and introduction of oximeters and oxygen supply.
Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers
Authors: Dao Kim , Thoueille Paul , Decosterd Laurent A. , Mercier Thomas , Guidi Monia , Bardinet Carine , Lebon Sébastien , Choong Eva , Castang Arnaud , Guittet Catherine , Granier Luc‐André , Buclin Thierry 
Published: January 2020

AbstractA pilot study was conducted aiming at specifying sultiame's pharmacokinetic profile, completed by in vitro assays evaluating the intraerythrocytic transfer of sultiame and by a pharmacokinetic model assessing its distribution. Single oral doses of sultiame (Ospolot® 50, 100, and 200 mg) were administered in open‐label to four healthy volunteers. Serial plasma, whole blood, and urine samples were collected. A spiking experiment was also performed to characterize sultiame's exchanges between plasma and erythrocytes in vitro. Pharmacokinetic parameters were evaluated using standard noncompartmental calculations and nonlinear mixed‐effect modeling. The plasma maximal concentrations (Cmax) showed striking nonlinear disposition of sultiame, with a 10‐fold increase while doses were doubled. Conversely, whole blood Cmax increased less than dose proportionally while staying much higher than in plasma. Quick uptake of sultiame into erythrocytes observed in vivo was confirmed in vitro, with minimal efflux. A two‐compartment model with first‐order absorption, incorporating a saturable ligand to receptor binding, described the data remarkably well, indicating apparent plasma clearance of 10.0 L/h (BSV: 29%) and distribution volume of 64.8 L; saturable uptake into an intracellular compartment of 3.3 L with a maximum binding capacity of 111 mg accounted for nonlinearities observed in plasma and whole blood concentrations. Pharmacokinetic characteristics of sultiame are reported, including estimates of clearance and volume of distribution that were so far unpublished. The noticeable nonlinearity in sultiame disposition should be taken into account for the design of future studies and the interpretation of therapeutic drug monitoring results.
Sustainable development and corporate social responsibility in Japanese manufacturing companies
Authors: Goto Mika , Sueyoshi Toshiyuki 
Published: January 2020

AbstractMany firms are now conscious about engaging in corporate social responsibility (CSR) for managing their business operations. The CSR is an approach that comprises a wide range of components such as corporate governance and workforce diversity. Among them, environmental protection has emerged as an important business issue in recent decades. This study focuses on the environmental protection from corporate efforts measured by CSR and socially responsible investment (SRI) that may serve as a proxy of CSR. This study considers that the level of sustainable development is measured by two unified (operational and environmental) efficiencies. To examine the sustainable development of Japanese manufacturing firms, we utilize a data set consisting of 110 manufacturing companies during 2013–2015. All the companies examined in this study are listed in the first section of the Tokyo Stock Exchange. This research first applies data envelopment analysis intermediate approach as a holistic method to assess their two efficiency measures. Then, we apply the panel data Tobit estimation to examine whether CSR and/or SRI influence their unified efficiency measures. This research finds that the SRI incorporation increases the efficiencies, enhancing their sustainable developments. However, the compliance with various CSR standards does not have such a direct influence probably because it increases complexity within firms.
Experimental study on flexural behavior of new type of prestressed reactive powder concrete sound barrier for high‐speed rail
Authors: Cao Xia , Yang Zhen‐Xuan , Zhu Wan‐Xu , Peng Han‐Ze , Fu Feng , Wang Long , Qian Kai 
Published: January 2020

AbstractIn this paper, four‐point bending tests of six prestressed reactive powder concrete (RPC) sound barrier unit panels were performed, the flexural behavior, deflection, and failure modes of both in situ and prefabricated panels were studied. The results show that the major failure modes for in situ panels were bending failure. Prestressing the panels can effectively increase the cracking loads and improve the stiffness of the in situ panels, but it cannot improve the ultimate flexural capacities. The ductility of the in situ panels decreased with the increase of prestressing degree. The stiffness of the prefabricated panels was improved by prestressing. Increasing the thickness of back and front plates, the ductility of the panels decreased accordingly, and the ductility of the prefabricated panels decreased more obviously than that of in situ panels. Based on the test results, considering tensile strength of RPC and prestressing stress, a modified formula for flexural capacity of in situ panels was established. In the meantime, considering the “bridge” effect of steel fiber, the formulae to calculate the crack width and deflection at service limit state were also developed for future design.
TRIM25 and its emerging RNA‐binding roles in antiviral defense
Authors: Choudhury Nila Roy , Heikel Gregory , Michlewski Gracjan 
Published: January 2020

AbstractThe innate immune system is the body's first line of defense against viruses, with pattern recognition receptors (PRRs) recognizing molecules unique to viruses and triggering the expression of interferons and other anti‐viral cytokines, leading to the formation of an anti‐viral state. The tripartite motif containing 25 (TRIM25) is an E3 ubiquitin ligase thought to be a key component in the activation of signaling by the PRR retinoic acid‐inducible gene I protein (RIG‐I). TRIM25 has recently been identified as an RNA‐binding protein, raising the question of whether its RNA‐binding activity is important for its role in innate immunity. Here, we review TRIM25's mechanisms and pathways in noninfected and infected cells. We also introduce models that explain how TRIM25 binding to RNA could modulate its functions and play part in the antiviral response. These findings have opened new lines of investigations into functional and molecular roles of TRIM25 and other E3 ubiquitin ligases in cell biology and control of pathogenic infections.This article is categorized under:
RNA in Disease and Development > RNA in Disease
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA Interactions with Proteins and Other Molecules > Protein–RNA Recognition
Identifying Birds' Collision Risk with Wind Turbines Using a Multidimensional Utilization Distribution Method
Authors: Khosravifard Sam , Skidmore Andrew K. , Naimi Babak , Venus Valentijn , Muñoz Antonio R. , Toxopeus Albertus G. 
Published: January 2020

ABSTRACTRenewable energy plays a key role in reducing greenhouse gas emissions. However, the expansion of wind farms has raised concerns about risks for bird collisions. We tested different methods used to understand whether birds' flight occurs over wind turbines and found kernel density estimators outperform other methods. Previous studies using kernel utilization distribution (KUD) have considered only the 2 horizontal dimensions (2D). However, if altitude is ignored, an unrealistic depiction of the situation may result because birds move in 3 dimensions (3D). We quantified the 3D space use of the Griffon vulture (Gyps fulvus) in El Estrecho natural park in Tarifa (southern Spain, on the northern shore of the Strait of Gibraltar) during 2012–2013, and, for the first time, their risk of collision with wind turbines in an area in the south of Spain. The 2D KUD showed a substantial overlap of the birds' flight paths with the wind turbines in the study area, whereas the 3D kernel estimate did not show such overlap. Our aim was to develop a new approach using 3D kernel estimation to understand the space use of soaring birds; these are killed by collision with wind turbines more often than any other bird types in southern Spain. We determined the probability of bird collision with an obstacle within its range. Other potential application areas include airfields, plane flight paths, and tall buildings. © 2020 The Authors. Wildlife Society Bulletin published by Wiley Periodicals, Inc. on behalf of The Wildlife Society.
Sex and season predict wounds in zoo‐housed Japanese macaques (Macaca fuscata): A multi‐institutional study
Authors: Cronin Katherine A. , Tank Amy , Ness Tom , Leahy Maureen , Ross Stephen R. 
Published: January 2020

AbstractJapanese macaque societies are characterized by frequent intragroup conflict both in free‐ranging and zoo‐housed conditions. In zoos, understanding the factors that contribute to wounding is of interest because this knowledge can aid in proactive husbandry and management planning that can minimize the negative impacts wounding can have on individual welfare. This study sought to determine whether the variables sex, season and age predicted wounding rates. Data were collected for 24 months on 119 Japanese macaques living in 10 zoos, and we analyzed the contribution of variables using generalized linear mixed models. A total of 1,007 wounds were reported, and the best model included the interaction between sex and season. Follow‐up analyses revealed that females incurred more wounds than males, and this sex difference was more pronounced during the breeding compared to the nonbreeding season. On average, individuals received 4.67 (±SEM: 0.55) wounds per year and 77.31% of the population incurred at least one wound in the study period. The majority of wounds were superficial and did not require veterinary intervention. Wound locations were not randomly distributed across body regions and were most often reported on the face. Finally, macaques living in larger social groups experienced more wounds, on average. This study represents the first quantification of wounding in this species and may provide insight to help inform husbandry and management strategies in zoos.
Introduction
Authors: Machado Helena , Granja Rafaela 
Published: January 2020

AbstractThe introductory chapter offers a detailed description of the themes that the reader can expect to find in this book, and a discussion of the social and academic relevance of the role and use of forensic genetic technologies in the criminal justice system. This introductory chapter provides the key concepts for the discussion of how developments in the application of forensic genetics can be understood as part of wider shifts in how the governance of criminality is enacted and made visible through the symbolic power invested in science and technology.
One-Sided Invertibility of Toeplitz Operators on the Space of Real Analytic Functions on the Real Line
Authors: Jasiczak M. , Golińska A. 
Published: January 2020

AbstractWe show that a Toeplitz operator on the space of real analytic functions on the real line is left invertible if and only if it is an injective Fredholm operator, it is right invertible if and only if it is a surjective Fredholm operator. The characterizations are given in terms of the winding number of the symbol of the operator. Our results imply that the range of a Toeplitz operator (and also its adjoint) is complemented if and only if it is of finite codimension. Similarly, the kernel of a Toeplitz operator (and also its adjoint) is complemented if and only if it is of finite dimension.
Toward the 1-cm Galileo orbits: challenges in modeling of perturbing forces
Authors: Bury Grzegorz , Sośnica Krzysztof , Zajdel Radosław , Strugarek Dariusz 
Published: January 2020

AbstractPrecise orbit determination demands knowledge of perturbing forces acting on the satellites of the Global Navigation Satellite Systems (GNSS). The metadata published by the European GNSS Agency for the Galileo satellites allow for the composition of the analytical box-wing model dedicated for coping with the direct solar radiation pressure (SRP), albedo, and infrared radiation (IR). Based on the box-wing model, we evaluated both the magnitude and the characteristic periods of accelerations caused by all the aforementioned forces. We assess which perturbations can be absorbed by the extended Empirical CODE Orbit Model (ECOM2) and what are the consequences of neglecting higher-order ECOM2 coefficients. In order to evaluate the impact of SRP, albedo, IR, and the navigation antenna thrust, we perform a series of precise Galileo orbit determination strategies for Galileo In-Orbit-Validation (IOV), Full Operational Capability (FOC), and two FOC satellites launched into eccentric orbits. The proposed box-wing model is capable of absorbing approximately 97% of the SRP in the Sun-satellite direction, whereas the rest can be mitigated by an additionally estimated small set of empirical parameters. The purely physical box-wing model does not fully handle satellite misorientation and re-radiation effects, such as Y-bias, solar panel rotation lag, that is the misalignment causing a constant acceleration perpendicular to the solar panel axis and the direction to the Sun. However, the box-wing model is especially crucial in terms of the absorption of the higher-order terms of SRP and stabilizes the orbit solutions during the eclipsing periods. Based on the SLR residual analysis, we found a systematic effect at the level up to 50 mm resulting from the omission of the high-order empirical orbit coefficients. We also found that the impact of the albedo, IR, and transmitter antenna thrust on the Galileo orbits reach the level of 5, 14, and 20 mm, respectively. Eventually, we obtain the overall accuracy of the Galileo-FOC orbits at the level of 22.5 mm, even for the eclipsing period for the solution which considers the box-wing model with the estimation of the constant empirical accelerations.
Visual motion sensitivity in descending neurons in the hoverfly
Authors: Nicholas Sarah , Leibbrandt Richard , Nordström Karin 
Published: January 2020

AbstractMany animals use motion vision information to control dynamic behaviors. For example, flying insects must decide whether to pursue a prey or not, to avoid a predator, to maintain their current flight trajectory, or to land. The neural mechanisms underlying the computation of visual motion have been particularly well investigated in the fly optic lobes. However, the descending neurons, which connect the optic lobes with the motor command centers of the ventral nerve cord, remain less studied. To address this deficiency, we describe motion vision sensitive descending neurons in the hoverflyEristalis tenax. We describe how the neurons can be identified based on their receptive field properties, and how they respond to moving targets, looming stimuli and to widefield optic flow. We discuss their similarities with previously published visual neurons, in the optic lobes and ventral nerve cord, and suggest that they can be classified as target-selective, looming sensitive and optic flow sensitive, based on these similarities. Our results highlight the importance of using several visual stimuli as the neurons can rarely be identified based on only one response characteristic. In addition, they provide an understanding of the neurophysiology of visual neurons that are likely to affect behavior.
Should MMMT still be treated with adjuvant taxane-based combination chemotherapy?
Authors: Heinzelmann-Schwarz Viola , Kind André B. , Vetter Marcus , Russell Kenneth , Omar Siti , Schoetzau Andreas , Hoeck Kerstin , Fink Daniel , Friedlander Michael L. , Hacker Neville F. 
Published: January 2020

Abstract
Background
Malignant mixed Mullerian tumors of endometrial (MMMT-E) and ovarian (MMMT-O) origin are associated with poor prognosis. Suggestively epithelial-driven tumors, their treatment has shifted from anthracycline or ifosfamide-based towards taxane-based chemotherapy. It remains unclear whether this change associates with better outcomes.

Patients and methods
A conjoined Australian and Swiss patient cohort of MMMT-E (N = 103) and MMMT-O (N = 17) was compared to patients with adenocarcinoma of the endometrium (EC, N = 172) and ovary (OC, N = 189). Clinicopathological characteristics, FIGO stage, first-line treatment, and patient outcomes were analyzed. The generated hypothesis was verified in an US-American cohort with high-grade serous ovarian cancer (HGSOC, N = 1290) and MMMT-O (N = 450) using immunohistochemistry and next-generation sequencing.

Results
Early stage I/II MMMT-E showed a survival plateau after 2.5 years, with no recurrence or death observed afterwards. Relapse-free survival was significantly worse in MMMT-E treated with platinum/taxanes (P = 0.024) compared to non-taxane regimen. Hypothesizing that also MMMT-O might benefit from an adjuvant non-paclitaxel regimen, a second independent cohort of MMMT-O and HGSOC patients was examined. p53 mutations dominated in both cancers with comparable frequency. PI3KCA and KRAS mutations were less frequent: they were more frequent in MMMT-O than in HGSOC (P = 0.015 and P = 0.018, respectively). MMMT-O responded better to a combination of carboplatin with anthracyclines than with taxanes (73.9% vs. 39.4%).

Conclusion
Early stage I/II MMMT-E patients have excellent prognosis if no recurrence has appeared within the first 2.5 years. In MMMT-E, platinum/anthracycline or ifosfamide regimen associated with better outcomes than platinum/taxanes regimens. This might also apply to MMMT-O.
Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for perforated low-grade appendiceal mucinous neoplasms
Authors: Abudeeb Haytham , Selvasekar Chelliah R. , O’Dwyer Sarah T. , Chakrabarty Bipasha , Malcolmson Lee , Renehan Andrew G. , Wilson Malcolm S. , Aziz Omer 
Published: January 2020

Abstract
Introduction
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an established treatment for pseudomyxoma peritonei (PMP) from perforated low-grade appendiceal mucinous neoplasms (LAMN II). In a selected group of LAMN II patients without established PMP, CRS/HIPEC can be performed laparoscopically (L-CRS/HIPEC); however the short-term benefits and safety of this approach have yet to be determined. This study aims to determine the short-term outcomes from a series of L-CRS/HIPEC LAMN II patients compared to those who have undergone a similar open operation (O-CRS/HIPEC) for low-volume PMP.

Methods
LAMN II patients undergoing L-CRS/HIPEC at a UK national peritoneal tumour centre were compared to O-CRS/HIPEC patients (peritoneal cancer index ≤ 7). Outcomes of interest included Clavien–Dindo complication grade, operative time, blood transfusions, high dependency unit (HDU) admission, length of hospital stay, and histopathological findings.

Results
55 L-CRS/HIPEC were compared to 29 O-CRS/HIPEC patients (2003–2017). Groups were matched for age, sex, and procedures. Median operative time was 8.8 (IQR 8.1–9.5) h for L-CRS/HIPEC versus 7.3 (IQR 6.7–8) h for O-CRS/HIPEC (Mann–Whitney test p < 0.001). Post-operative HDU admission was 56% versus 97% (OR 0.04 95% CI 0.01–0.34) and median length of stay = 6 (IQR 5–8) versus 10 (IQR 8–11) days (p < 0.001) for L- versus O-CRS/HIPEC. Despite a normal pre-operative CT scan, 13/55 (23.6%) L-CRS/HIPEC patients had acellular mucin and 2/55 (3.5%) had mucin with epithelium present in their specimens. Residual appendix tumour was identified in 2/55 patients (3.6%). Clavien–Dindo Grade 1–4 complications were similar in both groups with no mortality.

Conclusion
L-CRS/HIPEC for LAMN II takes longer; however patients have significantly reduced length of HDU and overall stay, without increased post-operative complications. A significant proportion of LAMN II patients undergoing L-CRS/HIPEC have extra-appendiceal acellular mucin with some cases demonstrating residual cellular epithelium from the LAMN II. The risk of these patients developing PMP without surgery is under current review.