bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Magnetic Resonance Imaging as a Potential Correlate in the Diagnosis of Alzheimer Disease: Exploratory Data Analysis
Authors: Khan Afreen , Zubair Swaleha 
Published: February 2020

BackgroundAlzheimer disease (AD) is a degenerative progressive brain disorder where symptoms of dementia and cognitive impairment intensify over time. Numerous factors exist that may or may not be related to the lifestyle of a patient that result in a higher risk for AD. Diagnosing the disorder in its beginning period is important, and several techniques are used to diagnose AD. A number of studies have been conducted on the detection and diagnosis of AD. This paper reports the empirical study performed on the longitudinal-based magnetic resonance imaging (MRI) Open Access Series of Brain Imaging dataset. Furthermore, the study highlights several factors that influence the prediction of AD.ObjectiveThis study aimed to correlate the effect of various factors such as age, gender, education, and socioeconomic background of patients with the development of AD. The effect of patient-related factors on the severity of AD was assessed on the basis of MRI features, Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), estimated total intracranial volume (eTIV), normalized whole brain volume (nWBV), and Atlas Scaling Factor (ASF).MethodsIn this study, we attempted to establish the role of longitudinal MRI in an exploratory data analysis (EDA) of AD patients. EDA was performed on the dataset of 150 patients for 343 MRI sessions (mean age 77.01 [SD 7.64] years). The T1-weighted MRI of each subject on a 1.5-Tesla Vision (Siemens) scanner was used for image acquisition. Scores of three features, MMSE, CDR, and ASF, were used to characterize the AD patients included in this study. We assessed the role of various features (ie, age, gender, education, socioeconomic status, MMSE, CDR, eTIV, nWBV, and ASF) on the prognosis of AD.ResultsThe analysis further establishes the role of gender in the prevalence and development of AD in older people. Moreover, a considerable relationship has been observed between education and socioeconomic position on the progression of AD. Also, outliers and linearity of each feature were determined to rule out the extreme values in measuring the skewness. The differences in nWBV between CDR=0 (nondemented), CDR=0.5 (very mild dementia), and CDR=1 (mild dementia) are significant (ie, P<.01).ConclusionsA substantial correlation has been observed between the pattern and other related features of longitudinal MRI data that can significantly assist in the diagnosis and determination of AD in older patients.
Stakeholder Perceptions of Internet-Delivered Cognitive Behavior Therapy as a Treatment Option for Alcohol Misuse: Qualitative Analysis
Authors: Hadjistavropoulos Heather D , Gullickson Kirsten M , Adrian-Taylor Shelley , Wilhelms Andrew , Sundström Christopher , Nugent Marcie 
Published: February 2020

Background
Internet-delivered cognitive behavior therapy (ICBT) has been found to be effective for treating alcohol misuse in research trials, but it is not available as part of routine care in Canada. Recent recommendations in the literature highlight the importance of integrating perspectives from both patient and health care stakeholders when ICBT is being implemented in routine practice settings.

Objective
This study aimed to gain an understanding of how ICBT is perceived as a treatment option for alcohol misuse by interviewing diverse stakeholders. Specifically, the objectives were to (1) learn about the perceived advantages and disadvantages of ICBT for alcohol misuse and (2) elicit recommendations to inform implementation efforts in routine practice.

Methods
A total of 30 participants representing six stakeholder groups (ie, patients, family members, academic experts, frontline managers, service providers, and health care decision makers) participated in semistructured interviews. To be included in the study, stakeholders had to reside in Saskatchewan, Canada, and have personal or professional experience with alcohol misuse. Interviews were transcribed verbatim, anonymized, and analyzed using thematic analysis.

Results
Stakeholders identified numerous advantages of ICBT for alcohol misuse (eg, accessibility, convenience, privacy, relevance to technology-based culture, and fit with stepped care) and several disadvantages (eg, lack of internet access and technological literacy, isolation, less accountability, and unfamiliarity with ICBT). Stakeholders also provided valuable insight into factors to consider when implementing ICBT for alcohol misuse in routine practice. In terms of intervention design, stakeholders recommended a 6- to 8-week guided program that uses Web-based advertising, point-of-sale marketing, and large-scale captive audiences to recruit participants. With regard to treatment content, stakeholders recommended that the program focus on harm reduction rather than abstinence; be evidence based; appeal to the diverse residents of Saskatchewan; and use language that is simple, encouraging, and nonjudgmental. Finally, in terms of population characteristics, stakeholders felt that several features of the alcohol misuse population, such as psychiatric comorbidity, readiness for change, and stigma, should be considered when developing an ICBT program for alcohol misuse.

Conclusions
Stakeholders’ insights will help maximize the acceptability, appropriateness, and adoption of ICBT for alcohol misuse and in turn contribute to implementation success. The methodology and findings from this study could be of benefit to others who are seeking to implement ICBT in routine practice.
Web-Supported Social Network Testing for HIV Among Men Who Have Sex With Men With a Migration Background: Protocol for a Mixed Methods Pilot Study
Authors: Op de Coul Eline , den Daas Chantal , Spijker Ralph , Heijman Titia , de Vos Marvin , Götz Hannelore , Vermey Koenraad , Zuilhof Wim , Van den Boogaard Jossy , Davidovich Udi , Zuure Freke ,   PREVENT Collaborators
Published: February 2020

Background
Of newly diagnosed HIV positive men who have sex with men (MSM) in the Netherlands, 29% have a non-Western migration background (MSM-NW). Among MSM-NW, HIV positivity rates are high (0.8%-2.0%), as is the proportion of late stage infections (39%). Factors such as HIV and sexual orientation–related stigma may form barriers for timely testing. Innovative approaches for HIV testing are needed to better reach MSM-NW. Social network testing (SNT) for HIV is an evidence-supported approach where peer recruiters identify persons (network associates) who could benefit from testing in their social or sexual networks. Web-supported SNT might be particularly promising for reaching people who may not be reached by regular care.

Objective
The purpose of this paper is to describe the design of our pilot PREVENT (Peer-Empowered Voluntary Extended Network Testing). In this pilot, we will explore whether SNT using HIV self-tests is feasible and acceptable among MSM-NW in the Netherlands and whether it reaches those who were never or not recently tested for HIV (&gt;1 year ago).

Methods
The project aims to include 50 to 60 MSM and MSM-NW peers who will distribute 4 to 5 oral HIV self-tests each aiming to reach 200 network associates (NAs). Enrollment of peers includes 4 steps: (1) fostering interest in becoming a peer by health care professionals at sexual health clinics, HIV treatment clinics, and community settings; (2) sending peer contact information to the peer coordinator; (3) registering peers and giving program instructions by the peer coordinator and referring to the Web-based training at time2test; and (4) receiving precoded HIV self-tests for distribution in the peers’ networks. NAs who receive the self-test will log in with their test package code in the time2test application for step-by-step test instructions. After testing is complete, NAs receive tailored follow-up information depending on their test result.

Results
Between January and May 2019, 10 STI clinics and 7 HIV treatment clinics started recruiting peers. Results of the PREVENT pilot are expected in December 2020.

Conclusions
This is the first Web-supported peer-driven SNT pilot using HIV self-tests in the Netherlands and one of the first in Europe. Implementation is considered successful if it reaches MSM-NW who were never or not recently tested for HIV. Additionally, it may encourage conversations within the networks about risk behavior and barriers to HIV testing, potentially contributing to the Joint United Nations Programme on HIV/AIDS goal of zero HIV infections.

Trial Registration
Netherlands Trial Registry NL7424; https://www.trialregister.nl/trial/7424

International Registered Report Identifier (IRRID)
DERR1-10.2196/14743
Perspective of Patients with Metastatic Breast Cancer on Electronic Access to Scan Results: Mixed-Methods Study
Authors: Baun Christina , Vogsen Marianne , Nielsen Marie Konge , Høilund-Carlsen Poul Flemming , Hildebrandt Malene Grubbe 
Published: February 2020

Background
Patient-accessible electronic health records give patients quick and easy access to their health care data, enabling them to view their test results online prior to a clinic visit. Hospital reports can be difficult for patients to understand, however, and can lead to unnecessary anxiety.

Objective
We aimed to investigate the attitudes and experiences of Danish patients with metastatic breast cancer in using electronic health records to view their own scan results.

Methods
We conducted a prospective mixed-methods study in a sequential design at our institution during 2018. Participants were women with metastatic breast cancer who were having scans every 3 months (combined positron emission tomography and computed tomography or computed tomography alone) to monitor treatment effects. Participants first received an online questionnaire about their knowledge and use of online access to scan results. We then conducted semistructured interviews with 4 women who used the online access to view their scan results.

Results
A total of 46 patients received the questionnaire (median age 66, SD 11.8, range 34-84 years). Of these women, 38 (83%) completed the survey (median age 69, SD 10.7, range 42-84 years). Most patients (34/38) were aware of the opportunity to access their reports online, but only 40% (15/38) used this access to read their scan results. Barriers to online access were (1) anxiety over reading the scan results in the absence of clinician support, and (2) a preference to receive all disease information at their next hospital appointment. The patients who read their scan result found that facilitators were greater transparency and empowerment, and barriers were the consequences of reading bad news, the feeling of dilemma about the access, and the medical terminology.

Conclusions
Patients with metastatic breast cancer generally had a positive attitude toward electronic access to their scan results, and those who used this opportunity played a greater participatory role in their disease and its management. Others described the potential distress this opportunity caused. The study findings suggest that immediate online access to scan results should be available to patients, but it needs a support function alongside that ensures optimal patient care.
El exilio libertario español y su impacto en la conformación de la Federación Anarquista Mexicana y el grupo Tierra y Libertad
Authors: Rodríguez Trejo Eduardo Daniel 
Published: February 2020

<p>Este artículo analiza la relación entre los anarquistas mexicanos y españoles una vez que la república española fue derrotada. Se aborda el momento fundacional de la Federación Anarquista Mexicana, espacio compartido por ácratas nativos e hispanos. Además, se evidencian las confrontaciones y disputas en el seno del movimiento libertario, situación concomitante con el surgimiento del grupo Tierra y Libertad, núcleo nacido en 1944 para, por un lado, sortear las dificultades impuestas a los extranjeros por la legislación mexicana; por otro, eludir las querellas intestinas del anarquismo; y, por último, elaborar nuevas estrategias y prácticas discursivas para divulgar sus principios.</p><p><strong> </strong></p>
THE DEVELOPMENT OF COURSEWARE BASED ON MATHEMATICAL REPRESENTATIONS AND ARGUMENTS IN NUMBER THEORY COURSES
Authors: Rosita Cita Dwi 
Published: February 2020

Courseware have an important role in the achievement of the objectives of education. Nevertheless, it does not mean any learning resources can be used for a type of learning. The teacher should provide and develop materials appropriate to the characteristics and the social environment of its student. Number Theory courses is one of the basic subjects that would be a prerequisite for courses at the next level, such as Linear Algebra, Complex Analysis, Real Analysis, Transformation Geometry, and Algebra Structure. Thus, the student’s understanding about the essential concepts that exist in this course will determine their success in studying subjects that mentioned above. In trying to understand most of the topics in Number Theory required the abilities of mathematical argumentation and representation. The ability of argumentation is required in studying the topic of complex number system, special operations, mathematical induction, congruence and divisibility. Ability representation especially verbal representations and symbols required by almost all the topics in this course. The purpose of this paper is to describe the development of teaching and learning Number Theory materials which facilitate students to develop the ability of mathematical argumentation and representation. The model used is a Thiagarajan development model consisting phases of defining, planning, development, and deployment. This paper is restricted to the analysis of the results of the materials validation from number theory experts.
Coronavirus (2019-nCov) Wuhan
Authors: Temte Jonathan 
Published: February 2020

Coronaviruses are an incredibly diverse family of viruses, found in many animal species, and are commonly encountered in clinical practice during the cold and flu season. We often encounter the common coronaviruses (HKU1, NL63, 229E and OC43) in our surveillance and epidemiological studies in schools, clinics and long-term care settings.
Criteria for determining the effectiveness of the law
Authors: Rybakov Vladimir A. 
Published: February 2020

The subject of the article concerns the assessment of the effectiveness of law. The purpose of the article is to identify indicators that reflect the effectiveness of the law.The methodology of the research includes complex analysis of scientific legal literature, synthesis of ideas as well as formal-legal method of interpretation of legal acts.The main results and scope of their application. More than 2500 existing normative legal acts of the Russian Federation contain various requirements for improving the efficiency of legal regulation. The complexity of the study is caused by the lack of a common understanding of the phenomenon. The effectiveness of the law is often understood by many authors as the ability to influence public relations in a certain direction useful for society; or as the ability to influence positively on social relations at the lowest cost; or as fundamental feasibility, predetermined by common knowledge, clarity and consistency of legal norms; the correspondence between the objectives of the legislator and development of social relations. An indicator of the effectiveness of legislation is a criterion for determining the degree of achievement of the goals and objectives of legal regulation. The indicators that are offered by scientists for assessment the effectiveness of law, has logical defects. These indicators are^ frequency of application of laws that are estimated for the effectiveness (I. Samoshchenko, V. I. Nikitinsky, A. B. Vengerov); measure of conflict regulated by this norm of social relations (V. Lapaeva); proportional ratio of the number of facts of lawful behavior to the number of cases of illegal behavior (T. Geiger and E. Hirsch), etc.Conclusions. The following formula can be proposed to determine the effectiveness of the law: effectiveness = LR2–LR1, where: LR1 - initial legal relations, and LR2 – the state of legal relations on the current date. Effectiveness can be measured in this formula in a number of violations and satisfied claims and complaints. There is no direct connection with the goal of legal regulation in this formula but it is possible, to trace the dynamics of the effectiveness of law with this formula by using statistics data.
Self-regulatory organizations as legal entities of public law
Authors: Masalab Anna F. 
Published: February 2020

The subject. The legal status of self-regulatory organizations based on the principle of mandatory membership was chosen as the subject of the research.The purpose of the article is to study the features of subjects of administrative law, vested with public powers, and substantiate the possibility of attribution of self-regulatory organizations with mandatory membership to legal entities of public law.The methodological basis for the study: general scientific methods (analysis, synthesis, comparison, description) as well as formal-legal interpretation of legislation and judicial acts.Results, scope of application. Two types of subjects can take part in administrative relations, as a rule: subjects performing public functions and endowed with authority for their implementation, and subjects not endowed with appropriate powers and representing an exclusively private interest. At the same time, the first group of subjects includes not only public-territorial entities, state authorities, but also organizations performing publicly significant functions.The legal definition of a legal entity does not reflect all the features of the legal status of these subjects, that is why the author refers to the concept of a legal entity of public law. Legal entities of public law have a special nature, different from legal entities of private law, since they have the right to make decisions affecting an indefinite range of persons.Conclusions. The analysis of the features of the legal entity of public law allocated in the literature (special legal nature; special social quality; special interests and will; connection with the public power; special way of creation; public-legal character of responsibility) allowed to justify that self-regulatory organizations are the kind of legal entities of public law - organizations performing publicly significant functions.
Effect of processing methods on consumer's acceptability and proximate composition of yellow croaker (Larimichthys polyactis)
Authors: Ayeloja Ayodeji Ahmed , George F. O.A. , Jimoh W. A. , Abdulsalami S. A. 
Published: February 2020

Effect of processing methods on consumer’s acceptability and proximate composition of yellow croaker was investigated. The experiment was completely randomized design where the treatments were the various processing methods employed. 12kg frozen yellow croaker fish were purchased, cut into chunks, divided into 4 groups of 3kg each, each group was salted and then subjected to different processing methods including: sun drying, deep- frying, solar drying and smoking. After processing, the products were subjected to organoleptic assessment using hedonic scale while the proximate composition was determined using standard experimental procedures. The result of this study indicates that the odour and flavour of smoked fish product were significantly (p < 0.01) preferred by consumers above other products. Solar dried fish product had highest percentage crude protein followed by smoked fish product while smoked fish product had the highest crude ash. This study suggests that it is better to process yellow croaker by solar drying and smoking so as to get good nutrients.
PENGARUH KEPEMILIKAN INSTITUSIONAL DAN INDIVIDUAL TERHADAP RISIKO EKSPROPRIASI PADA PERUSAHAN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Imam Muh Abdi 
Published: February 2020

tujuan penelitian ini adalah untuk menguji secara empiris pengaruh kepemilikan institusional dan kepemilikan individual terhadap risiko ekspropriasi pada perusahaan yang terdaftar di bursa efek indonesia priode 2010-2014.Penelitian ini dilakukan dengan mengunduh ringkasan laporan keuangan perusahaan non keuangan. Sampel terpilih sebanyak 71 perusahaan non keuangan yang terdaftar di BEI periode 2010-2014. Data dianalisis dengan regresi linear berganda menggunakan SPSS 21. Hasil penelitian menunjukkan kepemilikan institusional berpengaruh negatif terhadap risiko ekspropriasi dan kepemilikan individual berpengaruh positif terhadap resiko ekspropriasi
Analisis penyebab lemahnya fungsi sosial dan fungi bisnis Baitul Mal Wa Tamwil di Kota Makassar
Authors: Ridha Rasyid 
Published: February 2020

Hasil penelitian ini menunjukkan bahwa Penyebab lemahnya fungsi sosial dan fungsi Bisnis BMT tersebut adalah faktor Sumber Daya Manusia paling dominan menjadi penyebab lemahnya fungsi sosial dan bisnis BMT di kota Makassar, setelah itu faktor manajemen, faktor metode dan prosedur kerja, faktor dana, dan faktor lingkungan. Langkah prioritas yang penting dilakukan oleh para pengelola BMT adalah pembenahan peningkatan kuantitas dan kualitas pengurus, staf maupun karyawan, melalui pelatihan-pelatihan.Implikasi penelitian terhadap Analisis Penyebab Lemahnya Fungsi Sosial dan Fungsi Bisnis BMT di Kota Makassar akan memberikan informasi dan pemahaman bahwa ada beberapa faktor yang menyebabkan lemahnya fungsi sosial dan bisnis BMT di Kota Makassar, dari temuan beberapa faktor yang menyebabkan pelemahan BMT tersebut, maka perlu evaluasi kembali tentang implementasi filosofi BMT sebagai lembaga yang mengemban fungsi sosial dan fungsi bisnis sekaligus
Evaluasi dan Proyeksi Kebutuhan Bangunan Terminal Bandar Udara Internasional Kualanamu
Authors: Permatasari Andi Asri , Sandhyavitri Ari , Malik Alfian 
Published: February 2020

Bandara Internasional Kualanamu yang terletak di Kabupaten Deli Serdang, Provinsi Sumatera Utara memiliki luas eksisting (2016) seluas 118.930 m2 yang berkapasitas 8,9 juta penumpang per tahunnya yang dapat menampung penumpang pada jam sibuk sebanyak 4.134 penumpang. Hal ini menyebabkan kekhawatiran akan kapasitas bangunan terminal yang tidak dapat melayani kebutuhan penumpang pada tahun 2030. Penelitian ini bertujuan untuk mengevaluasi dan membuat proyeksi rencana kebutuhan bangunan terminal penumpang (2020-2030). Metodologi statistik regresi linier berganda diaplikasikan dalam membuat proyeksi penumpang ini. Volume penumpang dipakai sebagai variabel terikat (dependent variable). Adapun jumlah penduduk (Pdd) Provinsi Sumatera Utara dan PDRB Perkapita atas Dasar Harga Konstan Tahun 2010 (Pkt) Provinsi Sumatera Utara sebagai variabel bebas (independent variable) dengan bantuan program SPSS versi 23.0 serta Microsoft Excel maka dihasilakan, PDRB Perkapita (atas Dasar Harga Konstan Tahun 2010) berpenaruh kuat pada pertumbuhan penumpang domestic. Persamaan proyeksi volume penumpang = -9.098.309,11 + 0,498 Pkt dengan R2 0,935. Berdasarkan KP Nomor 482 Tahun 2018 tentang Rencana Induk Bandar Udara (RIB) Internasional Kualanamu Kabupaten Deli Serdang Provinsi Sumatera Utara digarisbawahi pentingnya pengembangan Bandar udara ini dimasa yang akan datang. Berdasarkan RIB dan penelitian ini pengembangan luasan bangunan terminal ini perlu dibuat secara bertahap. Rencana tahap 1 (2020-2025) diproyeksi kebutuhan luas bangunan terminal adalah 154.700 m2 dan untuk pengembangan tahap 2 (tahun 2025-2030) kebutuhan bangunan terminal adalah seluas 223.000 m2.