bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING RP-UPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF TEZACAFTOR AND IVACAFTOR IN FORMULATIONS
Authors: MANEKA S. LAKSHMI , SARAVANAKUMAR R. T. , ANJANA C. H. K. V. L. S. N. 
Published: September 2020

Objective: Aim of the present research work was to develop a sensitive, rapid and accurate, stability-indicating RP-UPLC method for the simultaneous estimation of tezacaftor and ivacaftor in formulations.
Methods: The chromatographic separation of the mixture of tezacaftor and ivacaftor was attained in isocratic method utilizing a mobile phase of 0.1 % orthophosphoric acid and acetonitrile in the proportion of 50:50%v/v utilizing a HSS C18 column which has dimensions of 100×2.1 mm, 1.7 m particle size and the flow rate of 0.3 ml/min. The detection system was monitored at 292 nm wavelength maximum with 1.5 ml injection volume. The present method was validated as per the guidelines given by the ICH for specificity, accuracy, sensitivity, linearity and precision.
Results: The retaining time for tezacaftor and ivacaftor were achieved at 1.071 min and 0.530 min, respectively. Tezacaftor, ivacaftor and their combined drug formulation were exposed to thermal, acidic, oxidative, photolytic, and alkaline conditions. The developed method was highly sensitive, rapid, precise and accurate than the earlier reported methods. The total run time was decreased to 2.0 min; hence, the technique was more precise and economical. Stability studies directed for the suitability of the technique for degradation studies of tezacaftor and ivacaftor.
Conclusion: The projected method can be utilized for routine analysis in the quality control department in pharmaceutical trades.
MOLECULAR DOCKING OF SELECTED BIOACTIVE COMPOUNDS FROM AZADIRACHTA INDICA FOR THE INHIBITION OF COVID19 PROTEASE
Authors: SHARON S. FEBINA BERNICE 
Published: September 2020

Objective: COVID-19 caused by novel SARS-coronavirus 2 belonging to family Coronaviridae, is a global public health emergency infecting many people all around the world, especially in India with more than 2,98,000 cases. Hence there is a need for a novel drug that counters SARS-CoV2 is the prime requirement at this time.
Methods: The present study aimed to assess bioactive compounds found in Azadirachta indica as a potential inhibitor of COVID-19 Mpr °(6Y2E, 6LU7, and 2GTB) by Autodock 4.2, with the Lamarckian Genetic Algorithm. COVID-19 Mpr ° was docked with thirteen bioactive compounds, and docking was analyzed by Autodock 4.2 and Pymol. Nelfinavir and Saquinavir were used as positive standards for comparison.
Results: Azadirachtanin, Azadirachtol, and Salannolide, were left out because of the violation of Lipinski’s rule. The binding energies obtained from the docking of 6Y2E with a native ligand, Azadiradione, Beta-sitosterol, Epiazadiradione, Epoxyazadiradione, Kaempferol, Meldenin, Myricetin, Nimbaflavone, Nimbinene, Nimbione, Nimbocinolide, Quercitrin, Vepnin, Saquinavir, and Nelfinavir were-7.32,-6.63,-6.69,-7.52,-5.27,-4.54,-6.07,-4.19,-5.02,-5.58,-6.23,-4.71, -3.72,-6.4,-7.14 and-4.67 kcal/mol respectively. The binding energies obtained from the docking of 6LU7 with the native ligand, Azadiradione, Nimbione, Vepnin, and Saquinavir were-6.14,-6.48,-6.79 and-6.49 kcal/mol correspondingly. The binding energies obtained from the docking of 2GTB with the native ligand, Azadiradione, Epiazadiradione, Epoxyazadiradione, Kaempferol, Meldenin, Myricetin, Nimbaflavone, Nimbione, Nimbocinolide, Quercitrin, Vepnin, Saquinavir, and Nelfinavir were-6.96,-7.13,-6.69,-5.22,-6.44,-5.06,-5.93,-6.66,-5.3,-5.63,-7.11,-6.89 and-5.42kcal/mol, respectively.
Conclusion: Azadiradione, Epiazadiradione, Nimbione, and Vepnin seemed to have the greatest potential to act as COVID-19 protease inhibitors. However, further research is necessary to explore their prospective medicinal use in vitro and in vivo conditions.
Effect of ascorbic acid on chemical content and viability of cocoa seed after storage
Authors: Sekewael Willy Daniel , Pudjihartati Endang , Santoso Teguh Iman 
Published: September 2020

Storage of oily seeds will make the seeds deteriorated, this caused by auto-oxidation. It will changes the biochemical and physiology of the seeds. Application of Antioxidant can prevent the activity of auto-oxidation. This research aimed to study the effect of ascorbic acid to minimize the deterioration by observing the chemical content and viability of Theobroma cacao L. seeds. It was conducted at kaliwining experimental station, Indonesia Coffee and Cocoa Research Institute, Jember, East Java and at Universitas Kristen Satya Wacana, Salatiga, Central Java. The research used Completely Randomized Design and T-test analysis. The treatments consisted of four ascorbic acid concentrations, i.e. 0 ppm as control, 250 ppm, 300 ppm, and 350 ppm. The treated cacao seeds were stored on two shelf life i.e. 1 week and 2 weeks. Each treatment was repeated with seven replications. Data analysis used SAS 9.0. The results showed that ascorbic acid application can effect on reducing sugar, protein, lipid, free fatty acid content, and viability of cocoa seeds. Ascorbic acid with concentration of 250 ppm and 300 ppm can maintain cocoa seeds viability until 2 weeks of shelf life.
Performance of Biochemical Compounds and Cup Quality of Arabica Coffee as Influenced by Genotype and Growing Altitude
Authors: Nugroho Dwi , Basunanda Panjisakti , Yusianto Yusianto 
Published: September 2020

Arabica coffee (Coffea arabica) cultivation in the medium altitude (700-900 m above sea level, asl.) will face problems such as decreasing productivity, physical, biochemical and cup quality and increasing intensity of pest and diseaseattacks. Utilization of plant material that has good productivity and cup quality, resistance to pests and diseases is an effort that can be done to overcome theseproblems. The aims of this study is to evaluate performance of Arabica coffee quality grown at high and medium altitude area, as well as biochemical compound and cup quality changes that occur due to influence of genotypes and genotype × altitude interactions. Eight genotypes of Arabica coffee were evaluated at two locations namely KP Andungsari (1,250 m asl.) and Kalibendo (700 m asl.). The field design for each location was randomized complete block design with three replicates. Observations were made on the two quality aspects, namely the biochemical compounds and cup qualities. The result on the biochemical compounds showed that the altitude significantly affect to the content of caffeine, sucrose, and trigonelline. Effect of genotype × altitude occured to the caffeine, trigonelline, and sucrose content. Diversity of chlorogenic acid content was caused by the genotype effect. Cup test results showed that genotypes grown at high altitude had a better cup quality than genotypes on medium altitude. Cup quality variables that were changed due to altitude difference were fragrance and aroma, flavor, aftertaste, acidity, balance, and overall, while the cup quality variable that did not changed was the body. Characters of coffee aroma at the high altitude were floral, spicy and fruity, while at the medium altitude were herbal, green and grassy. The best quality genotype at the high altitude was K8, while at the medium altitude was K29. Environment (altitude) gives greater influence to the formation of coffee flavor variations produced compared to genotypes.
The Role of Communication Mode in Auditor-Client Interactions: Insights from Staff Auditors
Authors: Carlisle Melissa , Hamilton Erin L. 
Published: September 2020

SUMMARY
Research suggests that staff auditors are more comfortable interacting with client personnel through email than face-to-face and that this choice of communication mode has the potential to impact audit outcomes. However, very little is known about how staff auditors choose a communication mode and its effects on their client interactions. Therefore, we present survey-based evidence that the majority of staff auditors prefer to interact with the client face-to-face but use face-to-face and email relatively equally. Auditors who primarily email the client place less value on client connection, and those who prefer email report feeling more communication anxieties related to the client. Importantly, the use of face-to-face communication is associated with more positive and productive client interactions. Firms can use the results of our study to understand the factors influencing staff auditors' preference for and use of different communication modes and its effect on audit outcomes, particularly as remote work increases.
Analisis Kausalitas Stabilitas Perekonomian Terhadap Pengembangan Bank Syariah Menggunakan Pendekatan Vector Error Correction Model
Authors: Windarsari Wiwin Riski , S Zainuddin 
Published: September 2020

Sektor keuangan memegang peran penting dalam mendorong perekonomian suatu negara. Sektor keuangan juga menjadi infrastruktur pendukung dalam memfasilitasi agar transaksi di sektor riil dapat dilakukan secara cepat, aman, dan efisien. Keseimbangan kedua sektor menjadikan ekonomi berjalan dengan sempurna. Keseimbangan ini secara simultan berimplikasi pada percepatan pembangunan dan peningkatan pertumbuhan ekonomi.Metode penelitian yang digunakan yaitu metode kuantitatif. Sumber data yang digunakan adalah data sekunder yang diperoleh dari Badan Pusat Statistik dan Otoritas Jasa Keuangan. Data diolah dan dianalisis menggunakan Vector Error Corection Model (VECM), menggunakan data dari bulan Oktober 2013 hingga September 2018. Variabel pada penelitian ini diantaranya PDB, inflasi, DPK, dan PYD.Berdasarkan hasil penelitian ini diperoleh hubungan satu arah DPK terhadap PDB, dan IHK terhadap PYD, serta terdapat hubungan dua arah antara PDB dan PYD. Hal ini menandakan bahwa bank syariah berkontribusi dalam mendorong perekonomian negara dan pertumbuhan ekonomi berkontribusi dalam penyaluran pembiayaan
Analytical Spectrometric Study For Determining Dapagliflozin Propanediol Monohydrate Individually Or In Presence Of Metformin Hydrochloride In Tablets Formulation
Authors: SAAD ANTAKLI  , Raghad Kabbani  , And Rama Labban  
Published: September 2020

First simple spectrophotometric method was developed and applied to determine Dapagliflozin Propanediol Monohydrate by Zero Spectrophotometry and First Derivative Spectrophotometric method for determining of Dapagliflozin Propanediol Monohydrate (DAPA) in the presence of Metformin Hydrochloride (MET). Zero spectrophotometric (ZS) was applied for the determination of (DAPA) at 223.5 nm. Linearity range was (2.61– 31.23) µg/mL. Regression analysis showed a good correlation coefficients R2 = 0.9989. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.569 µg/mL and 1.724 µg/mL, respectively. Derivative spectrophotometric (1DS) was applied for the determination of (DAPA) in the presence (MET). (DAPA) was determined at 233 nm (1D233). Linearity ranges were (5.21 – 41.64) µg/mL for (DAPA). Regression analysis showed a good correlation coefficients R2 = 0.9994. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.732 µg/mL and 2.218 µg/mL for (DAPA). The proposed Zero spectrophotometry method was applied to analysis individual (DAPA), and the derivative (1D233) method was applied to analysis (DAPA) individually or with (MET) combination in Syrian trademark drugs.
<i>Apgitir chrábaid</i> in the context of an intertextual approach
Authors: Kiselev M. S. 
Published: September 2020

This article is dedicated to methodological problems of intertextual relations studies which appear during the research of primary sources. The subject matter stands at the joint between several branches of knowledge: Religious studies, Cultural studies, Philology and Celtic studies. In this article, we make an attempt to find the most adequate methodological approach for the detection and description of intertextual relations. The source for our experiment would be an Irish primary source — Apgitir chrábaid, the earliest surviving Christian prose tract written in Old Irish. Moreover, the article contains a brief analysis of existing hypotheses which attempt to explain what exact Christian texts, written in Latin, influenced the structure and content of this treatise in particular: P.P. Ó Néill — John Cassian; T.O. Clancy and G. Márkus John Cassian and Basil the Great; A.A. Korolev — Isidore of Seville and John Cassian. Then we make critical remarks about the methodology of identification of said influences on Apgitir chrábaid chosen by those researchers and on the language of scientific description used by them. It is proposed to use methods developed within the theory of intertextuality as a more correct approach for marking and description of intertextual relations. The use of the intertextual description in working with primary sources is shown by the example of the analysis of the fragment from Apgitir chrábaid (§ 8). The result of the analysis is the hypothesis that the source of influence, the intertext, for the indicated fragment in addition to the text of the Holy Scripture, is the work «Homilies on Ezekiel» by Pope Gregory I the Great. As an additional argument in favor of this hypothesis, a brief review of the veneration of Pope Gregory I, recorded in Irish church literature, is given.
Associação entre a odontologia estética e autoestima
Authors: Oliveira Gabriella de Sá , Gusmão Yure Gonçalves , Nunes Flávio Marconiedson , Oliveira Isabela de Sá , Cangussu Lara Santos , Gonçalves Marcelo Cavalcanti 
Published: September 2020

Este artigo teve como objetivo realizar análise sobre a associação entre o trabalho da odontologia estética e a autoestima dos pacientes. Para isso foi realizado estudo bibliométrico de publicações científicas sobre o assunto. A busca inicial das referências bibliográficas foi efetuada na Biblioteca Virtual de Saúde (BVS), de forma integrada, de maio a agosto de 2019. O estudo contou com a seleção final de 20 referências de 212 publicadas a partir do ano de 2007. Dessas 212 referências, 192 foram excluídas por não atenderem os critérios de inclusão propostos no protocolo da pesquisa. De acordo com as referências, os fatores encontrados que impactam diretamente na autoestima dos indivíduos foram o edentulismo, amelogênese imperfeita, fluorose, dentes anteriores fraturados, diastema, sorriso gengival e posição inadequada da mandíbula. A deformidade dentofacial influencia não somente na autoconfiança, como também nos relacionamentos e qualidade de vida, resultando em impactos psicossociais. Todas as referências utilizadas neste estudo corroboram que a odontologia estética além de impactar no reestabelecimento da estética e função, atua na recuperação da autoestima. Desse modo, é de suma importância a preparação do profissional para que ele esteja apto a atender essa necessidade.
On using neurocontrol with delay in output feedback stabilization problem
Authors: Седова Наталья Олеговна , Токмаков Станислав Владимирович 
Published: September 2020

На примере перевернутого маятника на тележке продемонстрирован метод стабилизации механической системы обратной связью, не зависящей от скоростей. Возможность использования лишь значений координат обеспечивается запаздыванием обратной связи. Конструкция использует нейронную сеть, предполагая известным некоторое стабилизирующее управление по состоянию. Последнее строится в виде управления с переключением, допуская произвольные отклонения маятника от целевого верхнего положения.
A method is proposed for stabilizing an inverted pendulum on a cart by the feedback that is independent of the speed values. The possibility of using only coordinate values is provided by feedback delay. The design uses a neural network, assuming some stabilizing state control as known. The latter is constructed in the form of switching control, allowing arbitrary deviations of the pendulum from the desired upper position.
On one problem of portfolio analysis under soft constraints
Authors: Солдатенко Илья Сергеевич , Язенин Александр Васильевич 
Published: September 2020

Разработана и исследована модель портфеля минимального риска в условиях гибридной неопределенности возможностно-вероятностного типа, основанная на принципе ожидаемой возможности. Особенностью рассматриваемой модели является то, что «мягкость» ограничения на уровень ожидаемой доходности моделируется путем замены четкого ограничения возможностным бинарным отношением. На модельном примере показано, как мягкость ограничения влияет на множество квазиэффективных оценок инвестиционного портфеля.
A model of a minimal risk portfolio under conditions of hybrid uncertainty of the possibility-probability type based on the principle of expected possibility has been developed and studied. The peculiarity of this model is that the "softness" of the restriction on the level of expected return is modeled by replacing a clear restriction with a possibilistic binary relation. The model example shows how the softness of the constraint affects a set of quasi-effective estimates of an investment portfolio.
‘A Government of Transformation’: An Analysis of the Initial Education Policy Directions of the Labour-Led Coalition Government of New Zealand 2017–2018
Authors: Barker M , Wood Bronwyn 
Published: September 2020

© 2019, New Zealand Association for Research in Education. From the outset, the Labour-led Coalition Government of 2017 was intent on ‘transformation’. For the education sector, this was signalled immediately with the announcement of an extensive programme of review and reform initiated in their first 100 days of power. Yet, what is at the heart of the proposed changes and what were they trying to address? Drawing on Bacchi’s (Analysing policy: What’s the problem represented to be? Pearson, London, 2009) What’s the Problem Represented to Be? approach, we examine the significant problems identified by the in-coming Government through key public messages during their first 8 months (October 26th, 2017–June 30th, 2018). By analysing official discourses released by Ministers, we examine how the problems which the policies intended to address were constructed and represented to the public. Our analysis identified four main ‘problems’: the de-professionalisation of the teaching profession; the quality of public education; equity and access; and preparedness for the twenty first century. We conclude by examining how the representations of these problems may provide key insights into how imagined solutions are proposed and enacted in the future.
CUSTOMER EXPERIENCE MANAGEMENT IN BANKING SECTOR - A BRIEF REVIEW
Authors: Suvarchala  , Rao V. Narasimha 
Published: September 2020

The competition among the organizations in financial services sector is continuously increasing. Banking industry is a backbone of nation’s economy and it is one of the largest industries in India in terms of revenue and employment. The banking structure played a major role in the mobilisation of savings and promoting economic development. The intensity of customer-organisation relationship has changed dramatically over time. Customer experience is the product of an interaction between an organisation and a customer over the duration of their relationship. The key elements like strategy, culture, processes and systems etc. impact the CEM in banks. The antecedents like customer knowledge management, satisfaction, trust and loyalty influence the CEM in organizations. This paper is an attempt to trace out the elements of CEM and the various factors leading to the neglect of CEM in banking sector.
INTRODUCING ANTIOXIDANTS AS ESSENTIAL FOR THE MAINTENANCE OF TISSUE LIFE AS DEMONSTRATED IN HUMAN HAIR FOLLICLES
Authors: A Abraham 
Published: September 2020

Hair Follicles have been described as mini-organs having a wide range of functions and relying in tightly regulated molecular signaling for its metabolism, and extensively described to emit biomagnetic fields (BMFs). The ubiquitous enzyme catalase is essential for the eukaryotic cells to maintain toxic Reactive Oxygen Species (such as H2O2) in equilibrium. This manuscript presents a novel optical microscopy technique that utilizes a glass slide sandwich (SDW) where drops of fresh human blood are trapped. Drops of water are placed on the top slide of the SDW, in which a freshly plucked human hair follicle is immersed. In this experimental model, is shown that in water immersed follicles, BMFs interact with the intrinsic BMFs of the blood, this in turn causing vertically detected spatial images resembling two different magnetic profiles (MPs). When hairs are immersed in 35% H2O2 oxygen bubbles (O2) are displayed due to the H2O2 breakdown by the enzyme catalase. When the O2 breakdown ceases is theorized that tissue death has occurred. Results are presented of images and video-recordings correlating the absence of catalase with cessation of MPs.
EVALUATION OF TOMATO RESPONSE TO DEFICIT IRRIGATION AT HUMBO WOREDA, ETHIOPIA
Authors: Kifle Tamirneh 
Published: September 2020

Water scarcity, erratic rainfall distribution and better management of water are the most sever constraint for the development of agriculture. To cope with scarce supplies, deficit irrigation is an important tool to achieve the goal of reducing irrigation water use and increase water use efficiency (WUE) under scarce water resources. This research was carried out at Southern Agricultural Research Institute of Areka Agricultural Research Center of Hubo Woreda in farmers’ fields during 2016/2017–2017/2018 to identify the level of deficit irrigation which allow achieving optimum Tomato yield. The experimental design was arranged in RCBD with four treatments with three replications. The irrigation treatments were 100 % ETc, 85 % ETc, 75 % ETc and 50 % ETc. The result showed that a maximum fruit yield of 43.4 ton/ha was obtained under full irrigation. A deficit irrigation strategy applied at 85%, 70% of crop water requirement gives relatively better fruit yield i.e. 34.2 ton/ha and 32.1 ton/ha. For Tomato in water scarce area applying 85% and 70% of crop water requirement is recommended with a minimum reduction of yield.
EFFECT OF PREOPERATIVE PREPARATION ON PATIENTS OUTCOME AMONG PATIENTS UNDERGOING SURGICAL OPERATIONS AT ALMIK NIMIR HOSPITAL – SUDAN
Authors: Al amine Ali Eied Saber , Ahmed Abdallah Higazi Mohammed 
Published: September 2020

Preoperative preparations of the patients physically and psychologically are the cornerstone of the good outcomes. This prospective quasi-experimental hospital-based study was conducted in Sudan, Shendi city at Elmek Nimer university hospital to evaluate the impact of preoperative preparation on patients outcome among patients undergoing general surgery. In the period of June 2016 to May 2019.
The study was included a hundred patients undergoing general elective surgery, data were collected by interviewing questionnaire, anxiety scale, pain assessment tool, postoperative parameter, and patients satisfaction tool, data were collected in two phases (pre& postoperative). The data were analyzed by the computer software program (SPPS) version 20.
The results showed that more than two third (79.4%) of the patient had poor knowledge about the importance of preoperative preparations, but improve after implemented program and this was reflected on patient behavior and outcome in the postoperative phase. (70%) had reported no anxiety to mild in the postoperative phase. in regard of postoperative pain, majority of patients (70%) experienced moderate to severe level of pain in the first 4 hours, this level of pain reduce to mild to no pain level in (82%) of patients in next 12hours. Most of the patients had full to good satisfaction regarding preparations and outcome. The study support and justifies the effectiveness of the preoperative preparations on patient outcomes. The study recommended surgical nurses have to provide proper explanation and teaching for elective surgical patients to be adherence with the care plan to promote good surgical outcome.