bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Mechanisms of Glucose Uptake Regulation and Dilution Resistance in Growing Cancer Cells
Authors: Tveit Daniel M. , Fjeld Gunhild , Drengstig Tormod , Filipp Fabian V. , Ruoff Peter , Thorsen Kristian 
Published: January 2020

ABSTRACTMost cancer cells rely on aerobic glycolysis and increased glucose uptake for the production of biosynthetic precursors needed to support rapid proliferation. Increased glucose uptake and glycolytic activity may result in intracellular acidosis and increase of osmotically active substances, leading to cell swelling. This causes dilution of cellular constituents, which can markedly influence cellular reactions and the function of proteins, and hence, control mechanisms used by cancer cells to maintain a highly glycolytic phenotype must be robust to dilution. In this paper, we review the literature on cancer cell metabolism and glucose uptake, and employ mathematical modeling to examine control mechanisms in cancer cell metabolism that show robust homeostatic control in the presence of dilution. Using differential gene expression data from the Expression Atlas database, we identify the key components of glucose uptake in cancer, in order to guide the construction of a mathematical model. By simulations of this model we show that while negative feedback from downstream glycolytic metabolites to glucose transporters is sufficient for homeostatic control of glycolysis in a constant cellular volume, it is necessary to control intermediate glycolytic enzymes in order to achieve homeostatic control during growth. With a focus on glucose uptake in cancer, we demonstrate a systems biology approach to the identification, reduction, and analysis of complex regulatory systems.SIGNIFICANCERapid proliferation and increased glycolytic activity in cancer cells lead to dilution of cellular constituents, which can markedly influence cellular reactions and the function of proteins. Therefore, control mechanisms used by cancer cells to maintain a highly glycolytic phenotype must be robust to dilution. We construct a mathematical model of glucose uptake in cancer, and using a systems biology approach to the analysis of regulatory networks, identify the presence of integral control motifs as a means for achieving dilution resistance. Furthermore, we show that while negative feedback from downstream glycolytic metabolites to glucose transporters is sufficient for homeostatic control of glycolysis in a constant cellular volume, it is necessary to control intermediate glycolytic enzymes to achieve homeostatic control during growth.
Intelligent compaction practice and development: a bibliometric analysis
Authors: Liu Donghai , Wang Youle , Chen Junjie , Zhang Yalin 
Published: January 2020

PurposeThe purpose of this paper is to provide insights into the current practice, challenges and future development trends of intelligent compaction (IC) technology from a bibliometric perspective.Design/methodology/approachA bibliometric analysis on IC-relevant studies is presented. Through this quantitative manner, insights into the current IC research practice and development trends have been derived from the perspectives of publications and citations, spatial distribution, knowledge construction, structural variations, existing problems, and conclusions and recommendations.FindingsCurrently, IC applications are confronted with the issues of intelligent compaction measurement values (ICMVs) applicability, autonomous control, specifications and applications. To address the issues, three potential research directions are identified: a comprehensive ICMV measurement system that is designated for single layer analysis; autonomous control mechanisms with integrated management capabilities that can efficiently collaborate all stakeholders; and a standardized application workflow and the cost-benefit evaluation of IC in the context of the full life cycle.Research limitations/implicationsThe literature used in this paper is collected from the Web of Science. Although the database covers almost all the important publications in IC field, studies not indexed by the database are not considered.Originality/valueThis research quantitatively analyzes the current IC practice and development trends from the perspectives of bibliometric analysis. It provides an overview of the knowledge construction and development of IC technology. The discussions about the problems and the suggested solutions can be useful for those interested in this field.
Apprenticeship for craftspeople in the construction industry: a state-of-the-art review
Authors: Daniel Emmanuel Itodo , Oshodi Olalekan Shamsideen , Gyoh Louis , Chinyio Ezekiel 
Published: January 2020

PurposeApprenticeship programmes are designed to provide young trainees with essential broad-based skills. Through apprenticeships, different sectors that are underpopulated can fill up their skills gaps. Apprenticeships are particularly useful to the construction sector which has a high ageing workforce and associated lower labour productivity. However, the completion rates of apprenticeship training programmes in the construction sector remain low in several countries across the globe. Thus, the purpose of this paper is to review the published research on apprenticeship training that is specifically focused on the construction sector, to determine the current status quo and suggest a direction for future research.Design/methodology/approachA systematic review approach was adopted. Based on a comprehensive search using SCOPUS databases, 33 relevant journal articles were identified and analysed.FindingsIt was found that monitoring and control is the most mentioned factor responsible for improvements in the completion rates of apprenticeship training. In contrast, the length of time required for going through the full training is the most common factor responsible for low completion rates. Three research gaps were identified, among which is the dearth of studies that has focused on apprentices training in developing countries.Research limitations/implicationsThe gaps identified in the current knowledge on apprenticeship training would serve as a justification for future investigations. However, the scope of the review is limited to papers published in academic journals and citable through SCOPUS.Practical implicationsThe outcomes of the study provide researchers and other relevant stakeholders with a concise report on the findings of previous studies. It also provides insight into strategies for improving the completion rates of apprenticeship training in the construction sector.Originality/valueA systematic evaluation of the extant literature draws on theoretical evidence and highlights the factors that are more likely to influence the outcomes of apprentice training for craftspeople in the construction sector.
From making gadgets to making talents: exploring a university makerspace
Authors: Pettersen Inger Beate , Kubberød Elin , Vangsal Fredrik , Zeiner Axel 
Published: January 2020

Purpose
The maker movement has been gaining increased attention worldwide and has recently spread to universities, strengthening the entrepreneurial university. Makerspace communities are seen as open and democratic social spaces where knowledge sharing and peer-to-peer learning are essential. However, few scholars have examined the social learning dynamics in makerspace communities. The purpose of this paper is to contribute to these recent calls to investigate makerspaces and their relevance in enhancing learning in a university context.

Design/methodology/approach
The authors used a case study design to explore the social learning dynamics in the maker community. The authors used observations and interviews to gather rich data from ten members, including two founders. The study occurred over a five-month period.

Findings
In contrast to free-choice activities, this makerspace community practised a highly hierarchical and well-managed regulation of activities. The high emphasis on project work and serious play illustrates a community where technology is a means of delivering value through projects rather than a means to play and learn in itself.

Practical implications
Seen in the light of rapid technological development, educators are facing the danger of teaching outdated skills. The makerspace model represents an advanced type of pedagogy and mastery development in science, technology, engineering and mathematics subjects and has the potential to inspire educational designs while challenging traditional education.

Originality/value
The research provides insights into makerspace as a producer of talents, repositioning of technology transfer and value creation from an entrepreneurial university.
Potential pathways for proficiency training in computer maintenance technology among prospective electronic technology education graduates
Authors: Chukwuedo Samson Onyeluka , Ogbuanya Theresa Chinyere 
Published: January 2020

Purpose
The purpose of this paper is to investigate the cause–effect relationship between vocational support and the levels of acquisition of practical skills via learning self-efficacy during a training intervention in computer maintenance technology among vocational electronic technology students.

Design/methodology/approach
Quasi-experimental research was employed. The participants were 84 undergraduates of vocational electronic technology education in Nigeria. The study applied the modified stages of the Dreyfus model of skills acquisition as the training model. The study proposed a four-simple mediation models based on the first four stages of the modified Dreyfus model of skills acquisition (namely, novice, advanced beginner, competent and proficient stages) via practical skills learning self-efficacy.

Findings
The result showed significant effects of perceived vocational support in practical skills training on the levels of acquisition of practical skills in computer maintenance technology. Learning self-efficacy mediated the relationship between perceived vocational support and three levels of practical skills acquisition (advanced beginner, competent and proficient).

Research limitations/implications
All possible mediation pathways were not covered in this study. However, the study x-rayed the tendency of pathways in training intervention in vocational education and allied fields of study.

Practical implications
This study has empirically provided evidence to support the Dreyfus model of skills acquisition, as a plausible practical skills training model. Hence, the study can serve as a model for other researchers for replication in other fields of study.

Originality/value
To the authors’ knowledge, this is the first study that revealed potential pathways in work-related practical skills training interventions. The study has also validated the Dreyfus model as a potential skill acquisition model for practical skills training.
Developing a processual employability model to provide education for career self-management
Authors: Krouwel Sam Jan Cees , van Luijn Anna , Zweekhorst Marjolein B.M. 
Published: January 2020

Purpose
The purpose of this paper is to introduce a practical model for the evaluation and adaptation of educational programmes in order to incorporate employability development focussed on enabling graduates to self-manage their career.

Design/methodology/approach
The model integrates several perspectives on and conceptualisations of the nature of employability and its development. The integration of various elements is justified on the basis of existing research and the experience of local educational practitioners.

Findings
The model integrates insights from the Graduate Employability Development model (Harvey et al., 2002), the CareerEDGE model (Dacre Pool and Sewell, 2007), the Career Management Employability model (Bridgstock, 2009) and adopts three career competencies as outcome indicators (Akkermans et al., 2013). The resulting model describes in simple terms what educational practitioners may adapt in the process of employability development to enhance the ability of prospective graduates to manage their own careers.

Research limitations/implications
The model remains theoretical and the relations it implies require further validation. Involving graduates and students in evaluating the model may contribute to validating its scope and applicability.

Practical implications
The model provides a practical tool to retrospectively and prospectively evaluate the institutional provision of employability development education. It may serve as a basis for adaptation to other programmes.

Originality/value
By adopting a processual perspective on employability, the model shifts away from the possession of a predefined set of characteristics, and towards enabling students to actively influence their own employability.
Developing inclusive and quality learning environments in HEIs
Authors: Gill Seerat , Singh Gurparkash 
Published: January 2020

PurposeThe purpose of this paper is to redefine quality in the context of “access” providing higher education institutions (HEIs), through a theoretical lens, in order to find solutions to the wicked problem of access vs quality and “inclusiveness vs excellence” debate in higher education (HE).Design/methodology/approachThis theoretical paper builds upon institutional theory and resource dependency theory to, first, analyse access vs quality debate and, second, provide answers to the undesirable and at times conflicting “trilemma” of scale, cost and quality in HEIs. To achieve the second objective, the paper offers a different perspective to address trilemma by proposing a synergistic coexistence between inclusiveness and excellence through “transformative” quality and learning theory.Findings“Transformative” quality uses reframing the problem, appraising culture and quality concepts, and eventually develops transformative interventions in access providing HEIs to improve their quality and enhance inclusiveness. Inclusiveness in HEIs needs to be addressed through the investigation of specific hypotheses, for which a closer examination of factors impacting the quality of access providing HEIs has been conducted. The goal is to facilitate a perfect mélange of inclusiveness and excellence in HE and, thus, create a new learning environment.Research limitations/implicationsThis paper contributes towards the access vs quality debate through transformative quality by developing transformative interventions and investigating factors affecting quality in HE.Practical implicationsThe contribution has several policy, managerial and governance implications. Addressing these implications will enable the promotion of the third mission of HE, that is, to develop graduates who meaningfully engage with the society and their profession.Originality/valueQuality and inclusiveness is a serious global problem requiring immediate attention and rigorous theory-informed frameworks. Through the investigation of specific factors and proposing meaningful interventions, this paper identifies the need to study a critical issue having global implications and investigates how it can be resolved.
Evaluation of an English language peer tutoring intervention
Authors: Mackenzie Lee 
Published: January 2020

PurposeDesertion rates in Colombian universities remain unacceptably high. In the field of foreign languages, academic failure is particularly concerning since English language instruction is compulsory in most universities. To address the issue of poor student performance and high dropout rates, the University of Colombia has set up a peer tutoring scheme (PTS) for English as a foreign language (EFL) students in order to inform programme development. The paper aims to discuss this issue.Design/methodology/approachThe study was informed by realist evaluation principles. Qualitative in-depth interviews were conducted with eight PTS stakeholders supplemented by documentary analysis of the programme’s publicity material on the PTS website. The data were analysed using thematic analysis.FindingsFindings reveal discrepancies between the “espoused theory” about how the programme operates and the “theory-in-use”. In particular, according to stakeholders, the programme does not appear to be used by many of those EFL students who would benefit from it, which suggests that the programme is not as effective as it could be. Student and teacher contextual factors and mechanisms may explain the reasons for issues with programme effectiveness.Research limitations/implicationsFormative evaluations such as the current study can provide rich contextual information, but cannot be generalised to other settings. Also, this study does not explore the perspective of peer tutors and tutees, which means key variables may have been overlooked. Further research into the perspectives of tutors and tutees would therefore be needed to firm up these conclusions.Practical implicationsDue to the scarcity of literature into EFL peer tutoring interventions in higher education (HE), it is hoped that these findings will have relevance for similar contexts. The current evaluation highlights the influence of contextual factors such as willingness to ask for help, student motivation, student priorities, tutor credibility, teacher workload, timetabling and scheduling issues and involvement from teachers on the success of open-access peer tutoring programmes for EFL students in higher educational settings.Originality/valueAs far the researcher is aware, this is the first evaluation of an EFL peer tutoring programme in a private HE context in Colombia, and one of only a handful of studies into EFL peer tutoring programmes. The findings therefore have implications for those working in similar contexts.
Inducing stock market lexicons from disparate Chinese texts
Authors: Zhao Futao , Yao Zhong , Luan Jing , Liu Hao 
Published: January 2020

Purpose
The purpose of this paper is to propose a methodology to construct a stock market sentiment lexicon by incorporating domain-specific knowledge extracted from diverse Chinese media outlets.

Design/methodology/approach
This paper presents a novel method to automatically generate financial lexicons using a unique data set that comprises news articles, analyst reports and social media. Specifically, a novel method based on keyword extraction is used to build a high-quality seed lexicon and an ensemble mechanism is developed to integrate the knowledge derived from distinct language sources. Meanwhile, two different methods, Pointwise Mutual Information and Word2vec, are applied to capture word associations. Finally, an evaluation procedure is performed to validate the effectiveness of the method compared with four traditional lexicons.

Findings
The experimental results from the three real-world testing data sets show that the ensemble lexicons can significantly improve sentiment classification performance compared with the four baseline lexicons, suggesting the usefulness of leveraging knowledge derived from diverse media in domain-specific lexicon generation and corresponding sentiment analysis tasks.

Originality/value
This work appears to be the first to construct financial sentiment lexicons from over 2m posts and headlines collected from more than one language source. Furthermore, the authors believe that the data set established in this study is one of the largest corpora used for Chinese stock market lexicon acquisition. This work is valuable to extract collective sentiment from multiple media sources and provide decision-making support for stock market participants.
Mechanization level assessment and technology identification for productivity improvement in petrochemical facility maintenance
Authors: Yin Zhe , Caldas Carlos , de Oliveira Daniel , Hwang Bon-Gang , Shan Ming 
Published: January 2020

Purpose
Facility maintenance is critical for the operation and management of petrochemical plants. Maintenance work completed with higher productivity eventually contributes to better plant performance. Mechanization reduces workforce demand and can increase the productivity of maintenance work. The purpose of this paper is to assess the current mechanization level of the maintenance activities and then identify applicable technology solutions for productivity improvement in petrochemical facility maintenance.

Design/methodology/approach
This paper utilizes a mechanization level assessment method for global maintenance data collection and analysis. Subject matter experts’ interviews and market scanning were used to identify corresponding technology solutions.

Findings
The study discovered numerous maintenance activities with lower mechanization levels and identified more than 50 technology solutions applicable for maintenance productivity improvement.

Originality/value
This paper provides a roadmap for petrochemical maintenance work participants to assess their mechanization level status quo and identify technology solutions for higher maintenance work productivity. The method adopted is replicable and customizable for further applications with different plant conditions in the petrochemical sector and other industrial contexts.
Arctic expedition cruise tourism and citizen science: a vision for the future of polar tourism
Authors: Taylor Audrey R. , Barðadóttir Þórný , Auffret Sarah , Bombosch Annette , Cusick Allison Lee , Falk Edda , Lynnes Amanda 
Published: January 2020

Purpose
The purpose of this paper is to provide a conceptual framework for using citizen science – defined as a data collection method through which non-professionals engage in contributing to authentic scientific inquiry – within the expedition cruise industry to contribute significantly to the collection of environmental data from hard-to-access Arctic areas.

Design/methodology/approach
The authors review trends in Arctic expedition cruise tourism and current needs in Arctic research and monitoring, and clarify where the expedition cruise tourism industry could have the most impact by providing data to the scientific community. The authors also compare the regulatory context in the Antarctic to that in the Arctic and discuss how these differences could affect the widespread use of citizen science. At last, the authors describe some general principles for designing citizen science programs to be successful on board, and highlight several existing programs that are being recognized for their contributions to a greater scientific understanding of the Arctic.

Findings
The authors find that citizen science data from the expedition cruise industry are underutilized as a tool for monitoring Arctic change. Numerous examples illustrate how citizen science programs on-board expedition ships can successfully collect robust scientific data and contribute to enhancing the knowledge and stewardship capacity of cruise passengers. Inclusion of citizen science data from the expedition cruise industry should be considered a critical part of international Arctic observing networks and systems.

Social implications
Active participation in Arctic citizen science by tourists on expedition cruise ships has many potential benefits beyond the collection of high quality data, from increasing passengers’ knowledge and understanding of the Arctic while on board, to affecting their attitudes and behaviors after they return home.

Originality/value
The potential for tourism to contribute to Arctic observing systems has been discussed previously in the scientific literature; the authors narrow the focus to citizen science programs in the expedition cruise industry, and provide concrete examples, in the hope that this will streamline acceptance and implementation of these ideas by researchers and tourism practitioners.