bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic reaction norm models exploiting genotype × environment interaction on sexual precocity indicator traits in Nellore cattle
Authors: Mota L. F. M. , Fernandes G. A. , Herrera A. C. , Scalez D. C. B. , Espigolan R. , Magalhães A. F. B. , Carvalheiro R. , Baldi F. , Albuquerque L. G. 
Published: January 2020

SummaryBrazilian beef cattle are raised predominantly on pasture in a wide range of environments. In this scenario, genotype by environment (G×E) interaction is an important source of phenotypic variation in the reproductive traits. Hence, the evaluation of G×E interactions for heifer’s early pregnancy (HP) and scrotal circumference (SC) traits in Nellore cattle, belonging to three breeding programs, was carried out to determine the animal’s sensitivity to the environmental conditions (EC). The dataset consisted of 85 874 records for HP and 151 553 records for SC, from which 1800 heifers and 3343 young bulls were genotyped with the BovineHD BeadChip. Genotypic information for 826 sires was also used in the analyses. EC levels were based on the contemporary group solutions for yearling body weight. Linear reaction norm models (RNM), using pedigree information (RNM_A) or pedigree and genomic information (RNM_H), were used to infer G×E interactions. Two validation schemes were used to assess the predictive ability, with the following training populations: (a) forward scheme—dataset was split based on year of birth from 2008 for HP and from 2011 for SC; and (b) environment‐specific scheme—low EC (−3.0 and −1.5) and high EC (1.5 and 3.0). The inclusion of the H matrix in RNM increased the genetic variance of the intercept and slope by 18.55 and 23.00% on average respectively, and provided genetic parameter estimates that were more accurate than those considering pedigree only. The same trend was observed for heritability estimates, which were 0.28–0.56 for SC and 0.26–0.49 for HP, using RNM_H, and 0.26–0.52 for SC and 0.22–0.45 for HP, using RNM_A. The lowest correlation observed between unfavorable (−3.0) and favorable (3.0) EC levels were 0.30 for HP and −0.12 for SC, indicating the presence of G×E interaction. The G×E interaction effect implied differences in animals’ genetic merit and re‐ranking of animals on different environmental conditions. SNP marker–environment interaction was detected for Nellore sexual precocity indicator traits with changes in effect and variance across EC levels. The RNM_H captured G×E interaction effects better than RNM_A and improved the predictive ability by around 14.04% for SC and 21.31% for HP. Using the forward scheme increased the overall predictive ability for SC (20.55%) and HP (11.06%) compared with the environment‐specific scheme. The results suggest that the inclusion of genomic information combined with the pedigree to assess the G×E interaction leads to more accurate variance components and genetic parameter estimates.
Effects of white, yellow, and blue colored LEDs on milk production, milk composition, and physiological responses in dairy cattle
Authors: Son Jiseon , Park Jinryong , Kang Darae , Belal Shah Ahmed , Cha Jangock , Shim Kwanseob 
Published: January 2020

AbstractLight emitting diode (LED) is more energy efficient than incandescent or fluorescent light. This study was to evaluate effects of different colored LEDs on milk production, milk composition, and physiology of Holstein cow. According to milk production and parity, cows (n = 186) were allotted to four treatments: control (natural daylight), white, yellow, and blue LED groups. Of these, 40 cows that had passed 57 day‐in‐milk were used. Yellow and blue LED groups demonstrated greater rates of decline in milk production than control and white LED groups. At the finish point, milk fat, protein, and lactose contents were the lowest in the blue LED group, whereas milk–urea–nitrogen levels were the highest in the yellow and blue LED groups. Extended exposure to blue LED light lowered antioxidant enzyme activity and insulin‐like growth factor‐1 levels. Prolactin concentrations were higher in the white and blue LED groups than in the control. Cortisol level was the highest in the blue LED group among the groups. Nonesterified fatty acid levels in the yellow and blue LED groups decreased to the greatest extent compared to the start point. These results suggest that blue LED light can decrease milk production and generate more stress than white and yellow LED lights.
Names and naming in adoption: Birth heritage and family‐making
Authors: Pilcher Jane , Hooley Zara , Coffey Amanda 
Published: January 2020

AbstractIn this article, we consider the significance and practices of names and naming in adoption to develop understanding of the issue amongst scholars, policymakers, adoption practitioners, and adoption communities. Research on the topic of names and adoption is scarce and focused mostly on international and domestic adoptions in the United States. We draw on the research literature to critically explore names and naming in adoption through two recurrent and related themes. The first is “birth heritage,” where names, forenames especially, are shown to be important in the approach taken by adopters to their child's birth family and cultural identity. The second theme is “family‐making,” where namesaking and homogeneity of surname emerge, amongst others, as strategies to create, sustain, and display “family.” In gathering together for the first time an otherwise scattered, disparate body of research, our article showcases names and naming as illuminating distillations of key contemporary challenges experienced by families formed through adoption. We conclude our article by considering emergent gaps in existing knowledge and understanding about names, naming, and adoption that might usefully be addressed, to inform professional advice and familial decisions about names, and enhance outcomes for adoptees and their families.
Cutaneous “fibroma‐like” perivascular epithelioid cell tumor: A case report and review of literature
Authors: Odoño Eugene I. G. , Tan Kong‐Bing , Tay Sok Yan , Lee Victor Kwan Min 
Published: January 2020

AbstractPerivascular epithelioid cell tumors (PEComas) are a group of lesions sharing the common features of co‐expression of melanocytic and myogenic markers, with focal association of the cells with vascular walls. The PEComa group exhibits a wide range of morphologies. A “fibroma‐like” variant of PEComa has been recently described. The case reported herein is that of an infant with tuberous sclerosis complex (TSC) presenting with a lip mass. Excisional biopsy showed a moderately cellular tumor composed of spindled to stellate cells embedded within a collagenized stroma. The cells showed focal perivascular accumulation and positivity for both melanocytic (HMB‐45) and myogenic (desmin) markers. This is the fifth reported case of “fibroma‐like” PEComa in literature and the youngest patient to date. All of the “fibroma‐like” PEComas were found in patients with tuberous sclerosis—hence, the diagnosis of this entity should prompt a workup for TSC; conversely, a fibroma‐like lesion in a patient with TSC or with TSC‐related conditions should be evaluated using melanocytic and myogenic markers. Melanocytic and myogenic markers are also useful in differentiating “fibroma‐like” PEComa from other differential diagnoses such as fibroma and benign fibrous histiocytoma.
Two‐photon microscopic observation of cell‐production dynamics in the developing mammalian neocortex in utero
Authors: Kawasoe Ryotaro , Shinoda Tomoyasu , Hattori Yuki , Nakagawa Mami , Pham Trung Quang , Tanaka Yoshihiro , Sagou Ken , Saito Kanako , Katsuki Satoru , Kotani Tomomi , Sano Akihito , Fujimori Toshihiko , Miyata Takaki 
Published: January 2020

AbstractMorphogenesis and organ development should be understood based on a thorough description of cellular dynamics. Recent studies have explored the dynamic behaviors of mammalian neural progenitor cells (NPCs) using slice cultures in which three‐dimensional systems conserve in vivo‐like environments to a considerable degree. However, live observation of NPCs existing truly in vivo, as has long been performed for zebrafish NPCs, has yet to be established in mammals. Here, we performed intravital two‐photon microscopic observation of NPCs in the developing cerebral cortex of H2B‐EGFP or Fucci transgenic mice in utero. Fetuses in the uterine sac were immobilized using several devices and were observed through a window made in the uterine wall and the amniotic membrane while monitoring blood circulation. Clear visibility was obtained to the level of 300 μm from the scalp surface of the fetus, which enabled us to quantitatively assess NPC behaviors, such as division and interkinetic nuclear migration, within a neuroepithelial structure called the ventricular zone at embryonic day (E) 13 and E14. In fetuses undergoing healthy monitoring in utero for 60 min, the frequency of mitoses observed at the apical surface was similar to those observed in slice cultures and in freshly fixed in vivo specimens. Although the rate and duration of successful in utero observations are still limited (33% for ≥10 min and 14% for 60 min), further improvements based on this study will facilitate future understanding of how organogenetic cellular behaviors occur or are pathologically influenced by the systemic maternal condition and/or maternal‐fetal relationships.
Ventricular Dyssynchrony based on echocardiographic variables and exercise tolerance After right ventricular pacing: Impact of alternative septal lead locations
Authors: Mahfouz Ragab A , Mesbah Mohamed , Ammar Ahmad S , Khedr Mohammed H , Abdullah Radwa M 
Published: January 2020

AbstractObjectiveWe investigated the impact of alternative locations of right ventricular (RV) pacing on left ventricular function and its relation to exercise capacity.MethodsFifty patients who received a single lead pacemaker were divided according to RV pacing site into group 1 "high septum" (n = 15), group 2 "mid‐septum" (n = 25), and group 3 "low septum" (n = 10) using a documented fluoroscopic method. Dyssynchrony parameters were obtained using different echocardiographic parameters. Their exercise tolerance was evaluated after 6 months of pacemaker implantation using 6 minutes walk test (6 MWT).ResultsWe found a lesser degree of dyssynchrony in mid‐location and high location compared with low location pacing (radial dyssynchrony: P < .001; maximum temporal difference: P < .01; inter‐ventricular mechanical delay: P < .05, standard deviation of time‐to‐peak strain by tissue Doppler: P < .05). Sm was significantly increased 6 months following pacemaker implantation in group 1 and group 2 in contrast to group 3 patients (P < .05). Importantly, E/e' increased significantly (P < .001) in patients with low septal location pacing. Furthermore, 6 MWT distance was significantly improved (P < .001) in favor of groups 1 and 2. Importantly, the intra‐ventricular dyssynchrony with speckle tracking was considerably less in group 1 and 2 patients. Tps‐SL ≤ 120 ms was the optimal value to predict improvement in functional capacity following high to mid‐septal pacing locations.ConclusionThere was significant improvement of functional capacity after RV pacing in high and mid‐septal locations compared with low septal location. This was associated with a lesser degree of dyssynchrony in favor with mid‐ to high septal location.
Innovative Contaminant Mass Flux Monitoring in an Aquifer Subject to Tidal Effects
Authors: Jamin Pierre , Cosme Frédéric , Briers Pierre , Orban Philippe , De Greene Ken , Brouyère Serge 
Published: January 2020

AbstractExposure from groundwater contamination to aquatic receptors residing in receiving surface water is dependent upon the rate of contaminated groundwater discharge. Characterization of groundwater fluxes is challenging, especially in coastal environments where tidal fluctuations result in transient groundwater flows towards these receptors. This can also be further complicated by the high spatial heterogeneity of subsurface deposits enhanced by anthropogenic influences such as the mixing of natural sediments and backfill materials, the presence of subsurface built structures such as sheet pile walls or even occurrence of other sources of contaminant discharge. In this study, the finite volume point dilution method (FVPDM) was successfully used to characterize highly transient groundwater flows and contaminant mass fluxes within a coastal groundwater flow system influenced by marked tides. FVPDM tests were undertaken continuously for more than 48 h at six groundwater monitoring wells, in order to evaluate groundwater flow dynamics during several tide cycles. Contaminant concentrations were measured simultaneously which allowed calculating contaminant mass fluxes. The study highlighted the importance of the aquifer heterogeneity, with groundwater fluxes ranging from 10−7 to 10−3 m/s. Groundwater flux monitoring enabled a significant refinement of the conceptual site model, including the fact that inversion of groundwater fluxes was not observed at high tide. Results indicated that contaminant mass fluxes were particularly higher at a specific monitoring well, by more than three orders of magnitude, than at other wells of the investigated aquifer. This study provided crucial information for optimizing further field investigations and risk mitigation measures.
How to measure a latent construct: Psychometric principles for the development and validation of measurement instruments
Authors: El-Den Sarira , Schneider Carl , Mirzaei Ardalan , Carter Stephen 
Published: January 2020

AbstractMeasurement instruments are used to collect data about respondents. In social pharmacy, measurement instruments are often used to measure latent constructs, such as attitudes, among healthcare professionals and patients. This paper aims to describe the fundamental aspects of designing and validating instruments, which aim to measure latent constructs. The main focus of this manuscript is to describe the considerations and processes relating to exploratory and confirmatory factor analyses, when used to develop measures of latent psychosocial constructs. However, it also presents a detailed summary of the current evidence and suggestions for item generation and sample selection, as well as, an in-depth description of approaches to content and face validation. Suggestions for further reading are also provided.
Ischaemic stroke and transient ischaemic attack on anticoagulants: outcomes in the era of direct oral anticoagulants
Authors: Valente Michael , Leung Shelton , Wu Philip , Oh Danielle H. , Tran Hyuen , Choi Philip M. C. 
Published: January 2020

AbstractClinical and imaging characteristics of patients receiving direct oral anticoagulants presenting with transient ischaemic attack or stroke are lacking. A retrospective review of all patients who presented to a high‐volume primary stroke centre with acute stroke symptoms while prescribed an oral anticoagulant between January 2012 and June 2017. Clinical, radiological characteristics and functional outcomes were examined. Anticoagulated patients diagnosed with stroke or transient ischaemic attack shared similar disease and outcome characteristics irrespective of anticoagulants used. One‐third of warfarin patients with sub‐therapeutic international normalised ratios were treated with thrombolytics but no direct oral anticoagulants level was performed in any of the patients, with only one treated by intravenous thrombolysis.
Celebrating the career and contributions of Dr Henry T. Lynch (1928–2019)
Authors: Butel‐Simoes Grace I. , Macrae Finlay , Spigelman Allan D. 
Published: January 2020

AbstractThis article celebrates the career of Dr Henry Lynch and his contributions to cancer genetics through his extensive research, clinical practice and his passion for personalising care by using a patient's genetic profile to determine management and treatment. Dr Lynch's contributions were momentous and continue to have relevance to medical practice, in particular in the fields of clinical genetics, medical oncology and gastroenterology.
Disappearing investment‐cash flow sensitivities: Earnings have not become a worse proxy for cash flow
Authors: Andrén Niclas , Jankensgård Håkan 
Published: January 2020

AbstractAccording to a recent conjecture in the literature, earnings have become a poorer proxy for cash flow from operations over time. We find that since 1988, when cash flow statements started to be consistently reported in Compustat, the cash effectiveness of earnings has actually increased for a large sample of US manufacturing firms. This occurs despite the introduction of fair value accounting and increasing accounting accruals during the last three decades. Also contrary to the conjecture, using more comprehensive measures of cash flow does not restore the investment‐cash flow sensitivity, which continues to be around 0.05 in more recent periods.
Pulmonary veins anatomical determinants of cooling kinetics during second‐generation cryoballoon ablation
Authors: Borio Gianluca , Maj Riccardo , Alessandro Rizzo , Stroker Erwin , Sieira Juan , Osorio Thiago G. , Galli Alessio , Terasawa Muryo , Bala Gezim , Al Housari Maysam , Paparella Gaetano , Iacopino Saverio , Overeinder Ingrid , Brugada Pedro , de Asmundis Carlo , Chierchia Gian B. 
Published: January 2020

AbstractAimThe aim of the study was to investigate the role of anatomical characteristics of the pulmonary veins (PVs) determining cooling kinetics during second‐generation cryoballoon ablation (CbA).Methods and Resultswe enrolled all consecutive patients who underwent CbA for symptomatic atrial fibrillation in our center from January 2019 to March 2019. All patients had complete computed tomography scans of the heart before the ablation. Anatomical characteristics were tested for prediction of a nadir temperature (NT) ≤ −48°C. Significant differences were noted among PV max diameter (20.8 ± 2.8 vs 18.5 ± 2.5 mm; P < .001); PV minimum diameter (15.2 ± 3.0 vs 13.0 ± 3.1 mm; P < .001); PV area (268.1 ± 71.9 vs 206.2 ± 58.7 mm2; P < .001); PV ovality (1.4 ± 0.3 vs 1.5 ± 0.3; P = .005); and PV trunk length (27.4 ± 7.4 vs 21.3 ± 6.5 mm; P < .001). A scoring system was created by assigning one point each ranging from 0 (best anatomical combination) to 5. In the group with a score of 0, 94.0% of the CbA could reach a NT ≤ −48°C whereas with a score of 5, only 29.0% (P < .001). Left superior pulmonary vein with short trunk length and acute angle of PV branch was significantly associated with warmer NT (11.8% satisfactory CbA; P = .003). Regarding right inferior pulmonary vein, trunk length (P = .004), maximum diameter (P = .044), and transverse angle (P = .008) were independently associated with good NT.ConclusionAnatomical PV features are associated with cooling kinetics and an anatomical score could predict lower NT during second‐generation CbA. Specific characteristics were identified for inferior PV. Although heart imaging is not mandatory prior CbA, it can be a useful tool to predict cooling kinetics.
Choroidal thickness is associated with renal hemodynamics in essential hypertension
Authors: Geraci Giulio , Maria Zammuto Marta , Vadalà Maria , Mattina Alessandro , Castellucci Massimo , Guarrasi Giulia , Nardi Emilio , Maida Carlo , Zanoli Luca , Cillino Salvatore , Cottone Santina , Mulè Giuseppe 
Published: January 2020

AbstractThe choroid is the most vascularized structure of the eye and plays a central role in the development of the retinal vascular changes that occur in arterial hypertension. Changes of choroidal thickness (ChT) assessed by optical coherence tomography (OCT) technology could reflect the vascular complications of hypertension. Also, intrarenal hemodynamic damage, associated with endothelial dysfunction, demonstrated to be a good indicator of systemic morphofunctional arterial impairment. The aim of this study is to assess the relationship between ChT and renal hemodynamics in subjects with essential hypertension. Routine laboratory tests, clinical history, and physical examination, including blood pressure assessment, were performed in 90 subjects with essential hypertension. All patients underwent Doppler ultrasonographic evaluation of intra‐renal hemodynamics and OCT imaging to assess ChT. When subjects were divided in two groups based on renal resistive index (RRI), group I (RRI ≥ 75% percentile) showed significantly lower values of ChT than group II (RRI < 75% percentile) (P < .001). When divided in two groups based on the ChT median values, patients with lower ChT had significantly higher RRI values than those with ChT above the median values (P < .05). In multivariate model including age, eGFR, and other variables as confounding factors, RRI ≥ 75% was independently associated with ChT. ChT was significantly correlated with renal resistive index in subjects with essential hypertension, confirmed in multivariate analyses. This result could be referred to changes in vascular elastic properties that occur in retinal and intrarenal vascular system probably due to oxidative stress and endothelial dysfunction commonly found in early complications of hypertension.
Effect of Eryngium caeruleum essential oil on microbial and sensory quality of minced fish and fate of Listeria monocytogenes during the storage at 4°C
Authors: Mirahmadi Sepideh Sadat , Aminzare Majid , Azar Hassan Hassanzad , Kamali Koorosh 
Published: January 2020

AbstractThe present study investigated in vitro antimicrobial activity of Eryngium caeruleum essential oil (EEO) against five foodborne pathogenic bacteria based on microdilution and disk diffusion methods. Moreover, its effects on specific spoilage microorganisms, inoculated Listeria monocytogenes, and its sensory changes in minced fish were evaluated during 12 days of storage at refrigeration temperature. The results showed that Staphylococcus aureus and Escherichia coli were the most sensitive and the most resistant bacteria with a minimum inhibitory concentration of 0.125 and 1 mg/ml, as well as inhibition zones of 15.66 and 11.66 mm, respectively. Regarding the antimicrobial effect of EEO on the microbial profile and inoculated L. monocytogenes, treating with 0.4% EEO caused a significant decrease in the studied microorganisms when compared to the control group (p < 0.05). In addition, considering the sensory evaluation, the best scores were observed for the samples treated with 0.2% and 0.4% EEO. However, none of the groups obtained acceptable scores until the final day of storage except for the color attribute. In general, sensory evaluation and its correlation with microbial counting indicated that the treatment with 0.4% EEO was able to preserve the microbial quality of the minced fish at refrigeration temperature without any undesirable sensory effects.