bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between fears of cancer recurrence and patient age: A systematic review and meta‐analysis
Authors: Lim Edward , Humphris Gerald 
Published: February 2020

AbstractBackgroundFears of cancer recurrence (FCR) is one of the most prevalent concerns and a common unmet need reported by cancer patients. Patient age is a demographic variable that has been linked to FCR, among others. Although it is recognised by researchers that age and FCR may be negatively correlated, the strength of this correlation has yet to be established.AimThe aims of this study were to (a) conduct a meta‐analysis to investigate the overall association of patient age in years with FCR across studies from 2009 to February 2019 and (b) scrutinise for patterns of these effect sizes across studies.Methods and ResultsPeer‐reviewed papers were gathered from the literature via online databases (PubMed, EMBASE, MEDLINE, and PsycINFO). Systematic review guidelines including a quality assessment were applied to the 31 selected studies (pooled participant N size = 19 777). The meta‐analysis demonstrated a significant negative association between age and FCR (ES = −0.12; 95% CI, −0.17, −0.07). Meta‐regression revealed the association of patient age and FCR significantly reduced over the last decade. A significant effect (β = −0.17, P = 0.005) of breast cancer versus other cancers on this age by FCR association was also identified.ConclusionThe reliable and readily accessible personal information of age of patient can be utilised as a weak indicator of FCR level especially in the breast cancer field, where the majority of studies were drawn. The suggestion that age and FCR association may be attenuated in recent years requires confirmation.
How Quantum Dots Aggregation Enhances Förster Resonant Energy Transfer
Authors: Hottechamps Julie , Noblet Thomas , Brans Alain , Humbert Christophe , Dreesen Laurent 
Published: February 2020

AbstractAs luminescent quantum dots (QDs) are known to aggregate themselves through their chemical activation by carbodiimide chemistry and their functionalization with biotin molecules, we investigate both effects on the fluorescence properties of CdTe QDs and their impact on Förster Resonant Energy Transfer (FRET) occurring with fluorescent streptavidin molecules (FA). First, the QDs fluorescence spectrum undergoes significant changes during the activation step which are explained thanks to an original analytical model based on QDs intra‐aggregate screening and inter‐QDs FRET. We also highlight the strong influence of biotin in solution on FRET efficiency, and define the experimental conditions maximizing the FRET. Finally, a free‐QD‐based system and an aggregated‐QD‐based system are studied in order to compare their detection threshold. The results show a minimum concentration limit of 80 nM in FA for the former while it is equal to 5 nM for the latter, favouring monitored aggregation in the design of QDs‐based biosensors.
The momentary interplay of affect, attention bias, and expectancies as predictors of binge eating in the natural environment
Authors: Smith Kathryn E. , Mason Tyler B. , Juarascio Adrienne , Weinbach Noam , Dvorak Robert , Crosby Ross D. , Wonderlich Stephen A. 
Published: February 2020

AbstractObjectiveAffect regulation, eating expectancies, and attention toward food‐related cues are interrelated constructs that have been implicated in the maintenance of binge eating. While these processes show considerable temporal variability, the momentary associations between these domains have not been elucidated. This study examined a model that posited momentary fluctuations in affect, eating expectancies, and attention bias (AB) would interact to predict subsequent binge eating.MethodForty women who endorsed recurrent binge eating completed a 10‐day ecological momentary assessment protocol with ambulatory measures of AB (i.e., dot‐probe task with palatable food and neutral cues) and self‐report assessments of positive and negative affect, eating expectancies (i.e., the belief that eating would improve one's mood), and binge‐eating symptoms.ResultsGeneralized linear mixed models indicated higher momentary AB toward palatable food was associated with increased risk of subsequent binge eating, and a two‐way interaction showed that moments of higher eating expectancies and negative affect were associated with increased likelihood of subsequent binge eating. Also, a three‐way interaction emerged, in that the association between eating expectancies and subsequent binge eating was strongest at lower levels of positive affect and higher AB.DiscussionTogether, findings partially supported hypotheses and demonstrate meaningful within‐person fluctuations in AB that precede binge eating. Further, results demonstrate that the momentary influence of eating expectancies on binge eating depends on both affective state and attentional processes.
Temperature‐sensing ink and system for quality management in distribution from production to consumption
Authors: Aida Kohei , Tada Yasuhiko , Mori Shunsuke , Ishida Tomotoshi , Tokuda Yuya , Kawasaki Masahiro 
Published: February 2020

AbstractWe have developed a new ink technology that is able to detect individual deviations of manufactured products such as biologics, foods, and beverages in the temperature control under distribution by changes in the ink color. With the combined use of this ink and Internet of things technologies, we will create a consistent quality control system for logistics service from production to consumption.
Intraspecific variability drives functional changes in lichen epiphytic communities across Europe
Authors: Hurtado Pilar , Prieto María , Aragón Gregorio , de Bello Francesco , Martínez Isabel 
Published: February 2020

AbstractTraditional approaches in trait‐based community ecology typically expect that trait filtering across broad environmental gradients is largely due to replacement of species, rather than intraspecific trait adjustments. Recently, the role of intraspecific trait variability has been largely highlighted as an important contributor mediating the ability of communities to persist under changing conditions and determining the community‐level trait variation, particularly across limited environmental gradients. Unfortunately, few studies quantify the relative importance of species turnover versus intraspecific variability mediating the response of communities different from vascular plants. Here, we studied the functional changes in epiphytic lichen communities within 23 beech forests across large latitudinal (ca. 3,000 km) and environmental gradients in Europe to quantify the relative contribution of species turnover and intraspecific variability and the role of climate controlling community‐level trait changes. For 58 lichen species, we focused on a set of 10 quantitative functional traits potentially affected by climatic conditions and related to photosynthetic performance (n = 1,184 thalli), water use strategy (n = 1,018 thalli), and nutrient uptake (n = 1,179 thalli). Our results showed that intraspecific trait variability explained most of the functional changes in lichen communities in response to the latitudinal gradient. Further, such functional changes were determined by the covariation between intraspecific trait variability and species turnover, which varied in sign depending on the trait considered. Finally, different climatic predictors explained functional variation due to both intraspecific trait variability and species turnover. We propose that lichen communities cope with contrasting climatic conditions by adjusting the functional trait values of the most abundant species within the communities rather than by the replacement of the species. Consequently, intraspecific variability should be explicitly incorporated to understand the effect of environmental changes on lichen communities, even over large environmental variations, better. Our results challenge the universality of the hypothesis that species turnover chiefly drives functional trait changes across large environmental gradients and call for a wider test of such important assumptions in trait ecology in different organism types and ecosystems.
Invasive species interact with climatic variability to reduce success of natives
Authors: LaForgia Marina L. , Harrison Susan P. , Latimer Andrew M. 
Published: February 2020

AbstractPlants have evolved resource‐conservative and resource‐acquisitive strategies to deal with variability in rainfall, but interactions with dominant invasive species may undermine these adaptations. To investigate the relative effect of invaders on species with these two strategies, we manipulated rainfall and invasive grass presence and measured demographic rates in three resource‐acquisitive and three resource‐conservative native annual forbs. We found that invasive grasses were harmful to all of the target species, but especially the resource‐acquisitive ones, and that these effects were stronger under experimental drought. Invasive grass presence under drought lowered per capita population growth rates of acquisitive natives through increased mortality and decreased seed set. While invasive grasses also decreased per capita growth rates of resource‐conservative natives, they did so by increasing mortality under experimental watering and by limiting the production of seed under experimental drought. Invasive species can thus interact with climatic fluctuations to make bad years worse for resource‐acquisitive natives and good years less good for resource‐conservative natives, and they may generally tend to undermine the acquisitive strategy more than the conservative one.
Forecasting Chinese carbon emissions based on a novel time series prediction method
Authors: Li Yan 
Published: February 2020

AbstractMany calculation methods have been developed to forecast carbon emissions (CE). These methods can be classified into two categories: time series prediction and variables regression. However, time series prediction cannot fully use all CE‐related information and variables regression can only predict CE by knowing other variables in advance. To solve these problems, KLS is proposed in this paper which is a fusion of Kalman filter (KF), long short‐term memory (LSTM), and support vector machine (SVM). LSTM is used to predict CE as a time series, and 10 of 14 variables are selected by ridge regression (RR) to regress CE by SVM. Finally, KF is used to integrate the results of LSTM and SVM based on their variances. Overall, statistical filtering and deep learning algorithms are used in this paper, which achieved the fusion of time series prediction and variables regression. To confirm the effectiveness of KLS, we trained KLS model by CE from 1965 to 2005 and tested the model by the data from 2006 to 2014. The results showed KLS was more accurate than other four existing methods. Finally, we predicted the CE of China in next decade.
Long‐Term Outcomes After Transcatheter and Surgical Aortic Valve Replacement in Patients With Cirrhosis: A Guide for the Hepatologist
Authors: Peeraphatdit Thoetchai (Bee) , Nkomo Vuyisile T. , Naksuk Niyada , Simonetto Douglas A. , Thakral Nimish , Spears Grant M. , Harmsen William S. , Shah Vijay H. , Greason Kevin L. , Kamath Patrick S. 
Published: February 2020

Background and Aims
Hepatologists often determine whether transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) is preferred for patients with cirrhosis and severe aortic stenosis. The goal of this cohort study is to compare outcomes following TAVR and SAVR in patients with cirrhosis to inform the preferred intervention.

Approach and Results
Prospectively collected data on 105 consecutive patients with cirrhosis and aortic stenosis who underwent TAVR (n = 55) or SAVR (n = 50) between 2008 and 2016 were reviewed retrospectively. Two control groups were included: 2,680 patients without cirrhosis undergoing TAVR and SAVR and 17 patients with cirrhosis who received medical therapy alone. Among the 105 patients with cirrhosis, the median Society of Thoracic Surgeons score was 3.8% (1.5, 6.9), and the median Model for End‐Stage Liver Disease (MELD) score was 11.6 (9.4, 14.0). The TAVR group had similar in‐hospital (1.8% vs. 2.0%) and 30‐day mortality (3.6% vs. 4.2%) as the SAVR group. During the median follow‐up of 3.8 years (95% confidence interval, 3.0‐6.9), there were 63 (60%) deaths. MELD score (adjusted hazard ratio, 1.13; 95% confidence interval, 1.05‐1.21; P = 0.002) was an independent predictor of long‐term survival. In the subgroup of patients with MELD score <12, the TAVR group had reduced survival compared with the SAVR group (median survival of 2.8 vs. 4.4 years; P = 0.047). However, in those with MELD score ≥12, survival after TAVR, SAVR, and medical therapy was similar (1.3 vs. 2.1 vs. 1.6 years, respectively; P = 0.53).

Conclusion
In select patients with cirrhosis, both TAVR and SAVR have acceptable and comparable short‐term outcomes. MELD score, but not Society of Thoracic Surgeons score, independently predicts long‐term survival after TAVR and SAVR. For patients with MELD score <12, SAVR is a preferred procedure; however, neither procedure appears superior to medical therapy in patients with MELD score ≥12.
Girls’ attendance at school after a menstrual hygiene intervention in northern Ethiopia
Authors: Belay Shewaye , Kuhlmann Anne K. Sebert , Wall L. Lewis 
Published: February 2020

AbstractObjectiveTo evaluate the effect on school attendance of a menstrual hygiene intervention that distributes educational booklets to school children and menstrual hygiene kits to schoolgirls in northern Ethiopia.MethodsAttendance was tracked for 8839 students in grades 7–12 during the 2015–2016 academic year when the intervention was implemented. Negative binomial regression was used to test whether student sex predicted post‐intervention school absences when controlling for grade‐level and pre‐intervention absences. Similar attendance data were analyzed for 3569 students in grades 7, 9, and 11 for the 2014–2015 academic year as a historical comparison.ResultsOver 12 211 educational booklets were distributed to students and 5991 menstrual hygiene kits were distributed to schoolgirls. After the intervention, girls had 24% fewer school absences than boys. Sex was not a predictor of absences during a similar time‐period in the prior school year.ConclusionThis is one of the first large studies to show a positive relationship between a menstrual hygiene intervention and girls’ school attendance. These positive results suggest such interventions should be expanded to other schools in northern Ethiopia. Future research should explore whether similar interventions can also decrease the rate at which girls drop out of school around menarche.
Thermodynamic contribution of iodine atom to the binding of heterogeneously polyhalogenated benzotriazoles by the catalytic subunit of human protein kinase CK2
Authors: Marzec Ewa , Poznański Jarosław , Paprocki Daniel 
Published: February 2020

AbstractA series of novel benzotriazole derivatives containing iodine atom(s) were synthesized. The binding of these compounds to the catalytic subunit of human protein kinase CK2 was evaluated using differential scanning fluorimetry. The obtained thermodynamic data were compared with those determined previously for the brominated and chlorinated benzotriazole analogues to get a deeper insight into the thermodynamic contribution of iodine substitution to the free energy of ligand binding. We have shown that iodine atom(s) attached to the benzene ring of benzotriazole enhance(s) its binding by the target protein. This effect is the strongest when two iodine atoms are attached at positions peripheral to the triazole ring, which according to the structures deposited in protein data bank may be indicative for the formation of the halogen bond between iodine and carbonyl groups of residues located in the hinge region of the protein. Finally, quantitative structure–activity relationship analysis pointed the solute hydrophobicity as the main factor contributing to the binding affinity.
Removal of chlorophyll and tannins from Anthocleista schweinfurthii Gilg leaves by electrocoagulation using iron electrodes: optimization using response surface methodology
Authors: Tsopjio Francine Nkouam , Tchamango Serge Raoul , Momeni Jean , Monde Gaye , Tsopmejio Jean Paul , Ngassoum Martin Benoît , Darchen André 
Published: February 2020

AbstractBACKGROUNDAn electrocoagulation process using iron electrodes was applied for chlorophyll and tannins removal from ethanol extract of aerial parts of Anthocleista schweinfurthii Gilg. A second‐order regression using Central Composite Design (CCD) was used to investigate the main effects of four independent variables, namely supporting electrolyte concentration (in g L−1), ethanol percentage (%), current intensity (in amps) and electrolysis time (in minutes) and their interactions. The chlorophyll removal (CR), total tannins content (TTC) and total phenols content (TPC) were analyzed using response surface methodology (RSM) and CCD. Crude and optimized extracts were characterized by UV‐visible spectrometry and Fourier‐transform infrared spectroscopy.RESULTSThe RSM model obtained from the present study (R2 > 0.95) showed a good fit which suggests a good correlation between the predicted values and experimental results of CR and tannins removal. Under optimized conditions (supporting electrolyte concentration 2.4 g L−1; ethanol percentage 67%; current intensity 0.4 A and electrolysis time 75 min), CR of 98.23% and TTC of 58.83% were achieved while remaining 91.21% of TPC.CONCLUSIONEthanol percentage, current intensity and electrolysis time influences positively CR, TTC and TPC. According to the results, electrocoagulation is an appropriate technique indicated for extracting secondary metabolites while reducing the risks associated with the use of organic solvents. © 2020 Society of Chemical Industry
Early weaning modulates eating behavior and promotes hypofunction of the serotonergic (5HT) system in juvenile male rats
Authors: Tavares Gabriel Araújo , do Amaral Almeida Larissa Cavalcanti , de Souza Julliet Araújo , de Souza Felipe Leitão , Feitosa Braz Glauber Rudá , Silva Bruna Times , da Silva Santos Andresa Mayara , Lagranha Cláudia Jacques , de Souza Sandra Lopes 
Published: February 2020

AbstractEarly life stress (ELS) has been associated with developmental impairments. Early weaning (EW) is a postnatal stress model consisting of interruption of lactation and maternal care. The 5HT‐system has been associated with neurobehavioral modulations promoted by ELS. Thus, the present work aims to investigate the effects of early weaning on feeding behavior and serotonergic system of juvenile male rats. For this, rats were submitted to early (PND15) or natural (PND30) weaning and had the body weight, food intake in circadian phases, and food intake in response to fenfluramine assessed. mRNA expression of serotoninergic receptors (5HT1A and 5HT2C) and transporter (SERT) was assessed in the hypothalamus and brainstem, as well as NPY and POMC mRNA expression in hypothalamus. The results show that early weaning promoted changes in the percentage of weight gain during lactation period and increase in body weight at PND40. It was also observed that EW promoted increase and decrease in food intake in light and dark phase, respectively, and leads to a decreased action of fenfluramine on inhibition of food intake. In addition, early weaning promoted increased NPY and SERT mRNA expression in the hypothalamus and 5HT2C in the brainstem. Together, the data indicate that the stress caused by early weaning impairs the eating behavior of juvenile male rats through hypofunction of the 5HT‐system.
Distinct modes of TNF signaling through its two receptors in health and disease
Authors: Atretkhany Kamar-Sulu N. , Gogoleva Violetta S. , Drutskaya Marina S. , Nedospasov Sergei A. 
Published: February 2020

AbstractTNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is associated with the development of autoimmune diseases and other pathologies. Recent studies suggest that distinct functions of TNF may be associated with differential engagement of its two receptors: TNFR1 or TNFR2. In this review, we discuss the relative contributions of these receptors to pathogenesis of several diseases, with the focus on autoimmunity and neuroinflammation. In particular, we discuss the role of TNFRs in the development of regulatory T cells during neuroinflammation and recent findings concerning targeting TNFR2 with agonistic and antagonistic reagents in various murine models of autoimmune and neuroinflammatory disorders and cancer.
Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk
Authors: Hachim Mahmood Y , Khalil Bariaa A , Elemam Noha M , Maghazachi Azzam A 
Published: February 2020

Abstract
Pyroptosis is a newly discovered programmed cell death with inflammasome formation. Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as LPS of gram-negative bacteria are crucial to pyroptosis. Upon stimulation by pathogen-associated molecular patterns or damage-associated molecular patterns, proinflammatory cytokines, mainly IL-1 family members IL-1β and IL-18, are released through pyroptosis specific pore-forming protein, gasdermin D. Even though IL-1 family members are mainly involved in innate immunity, they can be factors in adaptive immunity. Given the importance of IL-1 family members in health and diseases, deciphering the role of pyroptosis in the regulation of innate and adaptive immunity is of great importance, especially with the recent progress in identifying the exact mechanism of such a pathway. In this review, we will focus on how the innate inflammatory mediators can regulate the adaptive immune system and vice versa via pyroptosis.
Treatment of Vestibular Migraine: A Systematic Review and Meta‐analysis
Authors: Byun Young Jae , Levy Dylan A. , Nguyen Shaun A. , Brennan Emily , Rizk Habib G. 
Published: February 2020

ObjectiveTo assess the efficacy of the various therapies used for the prevention of vestibular migraine (VM).MethodsPrimary studies were identified though PubMed, Scopus, PsycINFO, and Cochrane Library by two independent investigators for articles published through April 2019. The search identified randomized comparison or observational studies pertaining to vestibular migraine treatment. Meta‐analysis was performed on pre‐ and posttreatment Dizziness Handicap Inventory, vertigo frequency, and percentage of perceived improvement.ResultsLiterature search identified 13 studies that reported sufficient outcome measures to be included in the analysis. Patients with VM had a mean age of 43.3 years with female‐to‐male gender ratio of 2.1:1. Classes of therapeutic agents included antiepileptic drugs, calcium channel blockers, tricyclic antidepressants, β‐blockers, serotonin and norepinephrine reuptake inhibitors, and vestibular rehabilitation. All treatment options that were analyzed demonstrated improvement in all of the outcome parameters, but due to significant heterogeneity and lack of standardized reporting on outcomes, establishment of preferred treatment modality could not be determined.ConclusionsVarious treatment modalities have been evaluated for preventative treatment of VM. Physician familiarity, patient comorbidities, and the side‐effect profiles of various interventions likely influence the selection of intervention. Future randomized controlled trials with restrictive inclusion criteria and generalizable standardized outcome measures will allow for more robust meta‐analyses and for more evidence‐based treatment of vestibular migraines. Laryngoscope, 131:186–194, 2021