bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Perceptions, Opinions and Satisfaction of Telehealth With Remote Blood Pressure Monitoring Postpartum
Authors: Thomas Nicole , Drewry Anna , Passmore Susan , Assad Nadia , Hoppe Kara 
Published: December 2020

Abstract
Background: We conducted a post participation process evaluation of participant experiences with in-home remote patient monitoring via telehealth for blood pressure monitoring of women with postpartum hypertension. In collaboration with expert opinion, we developed a self-administered questionnaire to investigate patient factors we hypothesized to be relevant influencing participant perceptions. Factors included type of hypertension, medication, maternal demographics, and infant discharge rates. Methods: This analysis was a planned secondary analysis of a non-randomized controlled trial of telehealth with remote blood pressure patient monitoring for postpartum hypertension compared to standard outpatient monitoring in women with a hypertension-related diagnosis during pregnancy. In collaboration with survey experts, we developed a 41-item web-based survey to assess 1) perception of quality of care received, 2) ease of use/ease to learn the telehealth program, 3) effective orientation of equipment, 4) level of perceived security/privacy utilizing telehealth and 5) problems encountered. The survey included multiple question formats including Likert scale responses, dichotomous Yes/No responses, and free text. We performed a descriptive analysis on all responses and then performed regression analysis on a subset of questions most relevant to the domains of interest. The qualitative data collected through open ended responses was analyzed to determine relevant categories. Study participants received the survey at the 6-week study endpoint. Results: 60% of participants completed the survey. The majority of women found the technology fit easily into their lifestyle. Privacy concerns were minimal and factors that influenced this included age, BMI, marital status, and readmissions. 95% of women preferred remote care for postpartum follow-up, in which hypertensive type, medication use and ethnicity were found to be significant factors in influencing location of follow-up. Most women were satisfied with the devices, but rates varied by hypertensive type, infant discharge rates and BMI. Conclusions: Postpartum women perceived the telehealth remote intervention was a safe, easy to use method that represented an acceptable burden of care and an overall satisfying method for postpartum blood pressure monitoring. Trial registration: ClinicalTrials.gov identification number: NCT03111095, Date of registration: April 12, 2017.
KAUST Metagenomic Analysis Platform (KMAP), Enabling Access to Massive Analytics of Re-Annotated Metagenomic Data.
Authors: Alam Intikhab , Kamau Allan , Gugi David , Gojobori Takashi , Duarte Carlos , Bajic Vladimir 
Published: December 2020

Abstract
Exponential rise of metagenomics sequencing is delivering massive functional environmental genomics data. However, this also generates a procedural bottleneck for on-going re-analysis as reference databases grow and methods improve, and analyses need be updated for consistency, which require acceess to increasingly demanding bioinformatic and computational resources. Here, we present the KAUST Metagenomic Analysis Platform (KMAP), a new integrated open web-based tool for the comprehensive exploration of shotgun metagenomic data. We illustrate the capacities KMAP provides through the re-assembly of ~27,000 public metagenomic samples captured in ~450 studies sampled across ~77 diverse habitats, resulting in 36 new habitat-specific gene catalogs, all based on full-length (complete) genes. Extensive taxonomic and gene annotations are stored in Gene Information Tables (GITs), a simple tractable data integration format useful for analysis through command line or for database management. KMAP facilitates the exploration and comparison of microbial GITs across different habitats with over 275 million genes.
Tracking the Formation and Degradation of Fatty-Acid-Accumulated Mitochondria Using Label-Free Chemical Imaging
Authors: Zhang Chi , Boppart Stephen 
Published: December 2020

Abstract
The mitochondrion is one of the key organelles for maintaining cellular homeostasis. External environmental stimuli and internal regulatory processes alter the metabolism and functions of mitochondria. To understand these activities of mitochondria, it is critical to probe the key metabolic molecules inside these organelles. In this study, we used label-free chemical imaging modalities including coherent anti-Stokes Raman scattering and multiphoton-excited autofluorescence to study the mitochondrial activities in living cancer cells. We found that hypothermia exposure tends to induce fatty-acid (FA) accumulation in some mitochondria of MIAPaCa-2 cells. Autofluorescence images show that the FA-accumulated mitochondria also have abnormal NADH and FAD metabolism, likely induced by the dysfunction of the electron transport chain. We also found that when the cells were re-warmed to physiological temperature after a period of hypothermia, the FA-accumulated mitochondria changed their structural features, likely caused by the mitophagy process. To the best of our knowledge, this is the first time that FA accumulation in mitochondria was observed in live cells. Our research also demonstrates that multimodal label-free chemical imaging is an attractive tool to discover abnormal functions of mitochondria at the single-organelle level and can be used to quantify the dynamic changes of this organelle under perturbative conditions.
Response of the Carbon Budget of Global Forest Ecosystems to Future Climate Change
Authors: Xie Hongfei , ZHAO JUNFANG , Ma Jianyong , Yan Weixiong 
Published: December 2020

Abstract
Background At present, global warming is an indisputable fact, and more and more attention has been paid to the impacts of climate warming on global ecological environments. Forests play increasing significant roles in regulating global carbon balance and mitigating climate change. Therefore, to understand the response mechanisms of the carbon budget of global forest ecosystems to future climate change, an improved version of the FORest ecosystem Carbon budget model for CHiNa (FORCCHN) and future Representative Concentration Pathway (RCP) scenario RCP4.5 and RCP8.5 were applied in this study.Results The global forest ecosystems will play a major role in the carbon sink under the future two climate change scenarios. In particular, the average carbon budget (namely the Net Ecosystem Productivity, NEP) of global forest ecosystems under RCP4.5 scenario was estimated to be 0.017 kg(C)·m− 2·yr− 1 from 2006 to 2100. The future carbon sink areas of global forest ecosystems will increase significantly. Under RCP4.5 and RCP8.5 climate scenarios, the carbon sink areas of global forest ecosystems during 2026–2100 would be significantly higher than those in 2006–2025, with increases of 83.16–87.26% and 23.53–29.70%, respectively. The impacts of future climate change on NEP of global forest ecosystems will significantly vary between different regions. The NEP of forests will be enhanced in the northern hemisphere and significantly weakened in the southern hemisphere under the future two climate change scenarios. The carbon sink regions of global forests will be mainly distributed in the middle and high latitudes of the northern hemisphere. In particular, the forests'NEP in northeastern and central Asia, northern Europe and western North America will increase by 40%~80%. However, the NEP of forests will decrease by 20%~40% in the most regions of the southern hemisphere. In northern South America and central Africa, the forests' NEP will be reduced by more than 40%.Conclusions The global forest ecosystems will play a major role in the carbon sink under the future two climate change scenarios. However, the NEP of forests will be enhanced in the northern hemisphere and significantly weakened in the southern hemisphere. In the future, in some areas of southern hemisphere, where the forests' NEP was predicted to be reduced, some measures for improving forest carbon sink, such as strengthening forest tending, enforcing prohibiting deforestation laws and scientific forest management, and so on, should be implemented to ensure immediate mitigation and adaptation to climate change.
Stripe Skyrmions and Skyrmion Crystals
Authors: Wang X. R. , Hu X. C. , Wu H. T. 
Published: December 2020

Abstract
Skyrmions are important in topological quantum field theory for being soliton solutions of nonlinear sigma model and magnetics for their attractive applications in information technology. Either isolated skyrmions or skyrmion crystals may exist in a given chiral magnet, but not both at the same time. When skyrmion crystals, in which skyrmions often arrange themselves into triangular lattices, can be observed in a chiral magnet, stripy spin textures in various forms appear also and even mix with skyrmion crystals. People believe that skyrmions are circular objects and stripy spin textures have zero skyrmion number. Those stripy spin textures are called anything such as spiral, helical, and cycloid spin orders, but not skyrmions. Here we present convincing evidences showing that those stripy spin textures are skyrmions, ``siblings" of circular skyrmions in skyrmion crystals and ``cousins" of isolated circular skyrmions. Specifically, isolated skyrmions are excitations of chiral magnetic films whose ground states are ferromagnetic and skyrmion formation energy is positive. When the skyrmion formation energy is negative (relative to the single domain state), condensed skyrmions are the ground states and stripe skyrmions appear spontaneously. The density of skyrmion number determines the morphology of condensed skyrmion states. At the extreme of one skyrmion in the whole sample, the skyrmion has a ramified stripe structure that maximizes the skyrmion wall length in order to lower system energy. As the skyrmion number density increases, individual skyrmion shapes gradually change from ramified stripes to rectangular stripes, and eventually to disk-like objects due to the competition between negative formation energy and stripe-stripe or skyrmion-skyrmion repulsion. At a low skyrmion number density, the natural width of stripes is proportional to the ratio between the exchange stiffness constant and Dzyaloshinskii-Moriya interaction coefficient. At a high skyrmion number density, skyrmion crystals are the preferred states. Our findings reveal the nature and properties of stripy spin texture, and open a new avenue for manipulating skyrmions, especially condensed skyrmions such as skyrmion crystals.
A Prospective Study on the Pathogenesis of Catheter-associated Bacteriuria in Critically Ill Patients
Authors: Aumeran Claire , Mottet-Auselo Benoit , Forestier Christiane , Nana Paul-Alain , Hennequin Claire , Robin Frédéric , Souweine Bertrand , Traoré Ousmane , Lautrette Alexandre 
Published: December 2020

Abstract
Background Updating the pathogenesis of catheter-associated bacteriuria (CA-bacteriuria) in intensive care unit (ICU) is needed to adapt prevention strategies. Our aim was to determine the main pathway, endoluminal or exoluminal, of CA-Bacteriuria in ICU patients.In a prospective study, quantitative urine cultures were sampled from days 1 to 15 after catheterization, from catheter sampling sites, collection bags and catheter outer surface near the meatus. Endoluminal pathway was CA-bacteriuria (defined as 102 CFU/mL) first in collection bag then in catheter. Exoluminal pathway was CA-bacteriuria first in catheter, on day 1 in early cases and after day 1 in late cases. Results Of 64 included patients, 20 had CA-bacteriuria. Mean of catheterization days and incidence density were 6.81 days and 55.2/1000 catheter-days. Of 26 microorganisms identified, 12 (46.2%) were Gram positive cocci, 8 (30.8%) Gram negative bacilli and 6 yeasts. Three (11.5%) CA-bacteriuria were endoluminal and 23 (88.5%) exoluminal, of which 10 (38.5%) were early and 13 (50%) late. Molecular comparison confirmed culture findings. Quality audit showed good compliance with guidelines.ConclusionExoluminal pathway of CA-bacteriuria in ICU patients predominated and surprisingly occurred early despite good implementation of guidelines. This finding should be considered in guidelines for prevention of CA-bacteriuria.
Prognostic Value of the Preoperative Lymphocyte-to-monocyte Ratio for Survival After Lung Cancer Surgery
Authors: Ramos Ricard , Macía Iván , Navarro-Martín Arturo , Déniz Carlos , Rivas Francisco , Ureña Anna , Masuet Cristina , Moreno Camilo , Nadal Ernest , Escobar Ignacio 
Published: December 2020

Abstract
Background: The aim of this study was to assess the effect of the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with lung cancer treated with radical surgery on overall survival (OS), and disease-free survival (DFS).Methods: We performed a retrospective review of patients with lung cancer who prospectively underwent radical resection between 2004 and 2012. Prior to surgery, blood samples were taken as part of preoperative workup. The inflammatory markers studied were absolute values of lymphocytes, monocytes, neutrophils and platelets, with subsequent calculation of the ratios. Median follow-up was 52 months. Results: 268 patients underwent surgery, of whom 218 (81.3%) were men. Mean age was 62.9 ± 8.7 years. A lymphocyte-to-monocyte ratio ≥ 2.5 was independently associated with longer disease-free survival (hazard ratio [HR] 0.476 (0.307–0.738), p=0.001) and longer overall survival (HR, 0.546; 95% CI: 0.352-0.846; p=0.007), in models adjusted by age, sex, stage, and type of resection. No other systemic inflammatory marker showed a significant association. Conclusion: Preoperative lymphocyte-to-monocyte ratio is an independent prognostic factor in terms of overall survival and recurrence-free survival in patients with surgically resected early stage lung cancer.
Overactive Bladder Syndrome is Associated With Detrusor Overactivity and Abnormal Voiding Pattern in Nulliparous Women
Authors: Fang Jessica , Wu Ming-Ping , Yen Yu-Chun , Wu Jeng-Cheng , Chin Hung-Yen 
Published: December 2020

Abstract
Pregnancy and childbirth are frequently associated with overactive bladder syndrome (OAB). However, the role of parous effects in OAB among nulliparous (NP) women remains controversial. This study investigated abnormal voiding patterns and DO among NP woman with OAB in comparison with parous women. From August 2011 to December 2018, 906 patients met the inclusion criteria for participation and were divided into three groups: 221 patients in the NP group, 571 patients in the normal spontaneous delivery (NSD) group, and 114 patients in the cesarean section (CS) group. Urodynamic study (UDS) examinations were performed, and the presence of DO, abnormal voiding patterns, and maximum urethral closure pressure (MUCP) were recorded. Data were analyzed using analysis of variance, χ2 tests, and independent t tests. Compared with parous women in the NSD and CS groups, patients in the NP group had a significantly higher prevalence of abnormal voiding patterns, DO and MUCP. Furthermore, abnormal voiding patterns were significantly associated with DO and MUCP respectively, especially in the NP group. We hypothesized that hypertonicity or poor relaxation of the pelvic muscle in NP women may cause functional BOO, which is related to their OAB.
Use of The Bromocresol Purple Index (BCPI) in Measuring The Efficiency of Soybean Heat Treatment
Authors: Szmigielski Marek , Sobczak Paweł , Zawiślak Kazimierz , Andrejko Dariusz , Bielecka Grażyna , Rubaj Jolanta , Mazur Jacek 
Published: December 2020

Abstract
A number of the most common methods used in assessing the efficiency of soybean heat treatment were compared in this study. All the methods proved to be useful in assessing the efficiency of heating soybean seeds and soybean products. However, considering the sensitivity, precision, time consumed, and the effectiveness of determination of the characteristics of the samples, the use of purple bromocresol index (BCPI) appears to be justified. The BCPI method turned out to be universal, allowing distinguishing unheated (BCPIBSM <70 mg.g -1), under-heated (70 mg.g -1 <BCPI BSM <130 mg.g -1), properly heated (BCPI BSM = 130-140 mg.g -1), and over-heated samples (BCPI BSM > 140 mg.g-1).
How Intralymphatic Immunotherapy Can Affect Quality of Life and Symptoms in Patients With Permanent Seasonal Allergic Rhinitis, a Quasi-Experimental Design
Authors: Khoshkhui Maryam , Jabbari Farahzad , Zargar Fateme Shafiee , Haghi Nasrin Sadat Motevalli , Ariaee Nazila 
Published: December 2020

Abstract
BackgroundAllergen-specific immunotherapy is known as the only disease-modifying treatment for IgE-mediated allergic disorders. Intra lymphatic immunotherapy (ILIT) is a safe, effective, and time-saving alternative to subcutaneous immunotherapy (SCIT). This study aimed to evaluate the effects and safety of ILIT in patients with moderate to severe allergic rhinitis. MethodsIn this clinical trial, fifteen patients with moderate to severe allergic rhinitis between 18-65 years old received monthly intralymphatic inguinal injections of an active allergen (1000 SQ-U Salsola kali pollen). Clinical effects were assessed before and 4 weeks after treatment and at two consecutive pollination seasons and following non-pollination season in April.ResultsNo moderate or severe reactions were recorded following the ILIT treatment. Lymph node enlargement, local itching/erythema were seen in 6.7%, 13.3% of total respectively one day after injection. Patients who received ILIT experienced a significant clinical improvement in self-recorded seasonal allergic symptoms after treatment, as compared to themselves before ILIT. Quality of life significantly got better based on the Mini RQLQ questionnaire.ConclusionAlthough this study is based on a limited number of patients, ILIT with Salsola-pollen extract appears to decrease symptoms of allergic rhinitis without causing any crucial complications.This clinical trial study was recorded in the Iran Registry of Clinical Trials (IRCT20161206031256N2).
Pentavalent Vaccination in Rural Kenya: Coverage and Geographical Accessibility to Health Facilities Using Data from a Community Demographic and Health Surveillance System in Kilifi County.
Authors: Ogero Morris , Orwa James , Odhiambo Rachael , Agoi Felix , Lusambili Adelaide , Obure Jerim , Temmerman Marleen , Luchters Stanley , Ngugi Anthony 
Published: December 2020

Abstract
BackgroundThere is substantial evidence that immunization is one of the most significant and cost-effective pillars of preventive and promotive health interventions. Effective childhood immunization coverage is thus essential in stemming persistent childhood illnesses. The main indicator of performance of the immunisation programme is the third dose of diphtheria-tetanus-pertussis (DTP3) vaccine for children because it mirrors the completeness of a child’s immunisation schedule. Spatial access to a health facility, especially in SSA countries, is a significant determinant of DTP3 vaccination coverage, as the vaccine is mainly administered during routine immunisation schedules at health facilities. Rural areas and densely populated informal settlements are most affected by poor access to healthcare services. We therefore sought to determine vaccination coverage of DTP3, estimate the travel time to health facilities offering immunisation services, and explore its effect on immunisation coverage in one of the predominantly rural counties on the coast of Kenya.MethodsCoordinates of health facilities, information on land cover, digital elevation models, and road networks were used to compute spatial accessibility to immunizing health facilities for eligible children within the Kaloleni-Rabai Community Health Demographic Surveillance System (HDSS). To explore the effect of travel time on DTP3 coverage, we fitted a hierarchical multivariable model adjusting for other a priori identified confounding factors.ResultsSpatial access to health facilities that offer immunization services significantly affected DTP3 coverage, with travel times of more than one hour to a health facility significantly associated with reduced odds of receiving DTP3 vaccine (AOR= 0.84 (95% CI 0.74 – 0.94).ConclusionIncreased travel time is a significant barrier to the uptake of facility-delivered immunizations in this rural community. To improve immunisation coverage, local health authorities and policy makers in remote settings can use high-resolution maps to identify areas where distance and travel time may impede the achievement of high immunization coverage and identify appropriate interventions. These could include improving the road network, establishing new health centres and/or stepping up health outreach activities that include vaccinations in hard-to-reach areas within the county.
Associations of Prepregnancy Body Mass Index and Gestational Weight Gain with Intelligence in Offspring: A Systematic Review and Meta-analysis
Authors: Zhu Simeng , He Yichen , Zhang Chen , Wu Yanting , Huang Hefeng 
Published: December 2020

Abstract
Background: As a growing health problem, maternal obesity may have an adverse effect on offspring neurodevelopment. The effects of maternal overweight and obesity and excessive gestational weight gain on offspring intelligence remains unclear. This meta-analysis aimed to assess the influence of prepregnancy body mass index (BMI) and gestational weight gain on children’s intelligence.Methods: We systematically searched PubMed, Embase, Cochrane Library and Ovid Medline from their inception through July 2020. Studies assessing the association between prepregnancy BMI or gestational weight gain and children’s intelligence (from 3 years to 10 years) were screened manually before final inclusion. We included prospective and retrospective cohorts that analysed the association between prepregnancy BMI or gestational weight gain and intelligence of offspring. We used the Mantel-Haenszel fixed-effects method to compute the weight mean difference (WMD) and 95% confidence interval (CI) of each study.Results: Twelve articles were included in the systematic review, and six of them were included in the meta-analysis. There was a significant full-scale IQ reduction in children of overweight and obese women, with WMDs of -3.25 (95% CI: -3.05, -2.42) and -4.85 (95% CI: -5.93, -3.76), respectively. Compared with that in the control group, the WMDs for performance IQ were -2.40 (95% CI: -3.45, -1.34) and -5.28 (95% CI: -7.22, -3.34) in the overweight and obesity groups, respectively, and the WMDs for verbal IQ were -3.47 (95% CI: -4.38, -2.56) and -5.71 (95% CI: -7.13, -4.29), respectively. However, there was no significant reduction in children’s full-scale intelligence scores due to excessive weight gain; the WMD was -0.14 (95% CI: -0.92, 0.65).Conclusions: Prepregnancy overweight and obesity might have disadvantageous consequences on children’s intelligence; however, we observed no significant difference between excessive and normal gestational weight gain. Therefore, weight control before pregnancy is more important than that during pregnancy in terms of children’s intelligence.Trial registration: This systematic review and meta-analysis have been registered in PROSPERO (Number: CRD42020199215).