bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matched Photometric Catalogs of GALEX UV Sources with Gaia DR2 and SDSS DR14 Databases (GUVmatch)
Authors: Bianchi Luciana , Shiao Bernard 
Published: October 2020

Abstract
We have matched the ultraviolet (UV) sources in GUVcat_AIS with optical databases that have similar depth and wide sky coverage. GUVcat_AIS has Galaxy Evolution Explorer (GALEX) far-UV (FUV, λ
eff ∼ 1528 Å) and near-UV (NUV, λ
eff ∼ 2310 Å) photometry of ≈83 million sources, covering 24,788 square degrees of the sky, with a typical depth of FUV = 19.9 and NUV = 20.8 AB mag. Matches with Gaia and the Sloan Digital Sky Survey (SDSS) databases are presented here. Gaia data release 2 (DR2), covering the entire GUVcat footprint, detected about one-third of the GUVcat_AIS sources. We found 31,925,294 Gaia DR2 counterparts to 30,024,791 GUVcat_AIS unique sources, with photometry in the Gaia G band and often also in Gaia BP and RP bands; 26,275,572 matches have a parallax measurement, 21,084,628, 18,588,140, and 16,357,505 have a parallax error less than 50%, 30%, and 20%, respectively. The match with SDSS data release 14 (DR14) yields 23,310,532 counterparts to 22,207,563 unique GUVcat_AIS sources, 10,167,460 of which are pointlike, over a total overlap area of ≈11,100 square degrees (Bianchi et al. 2019). SDSS adds five optical magnitudes to the UV photometry : u, g, r, i, z, and optical spectra of 860,224 matched sources. We used a match radius of 3″, consistent with previous works, although the positions agree to ≲15 for the majority of (pointlike) matched sources, in order to identify possible multiple matches whose UV flux could be unresolved in GALEX imaging. The catalogs can be trimmed to a tighter match radius using the provided separation. The multiband photometry is used to identify classes of astrophysical objects that are prominent in UV, to characterize the content of the GUVmatch catalogs, where stars in different evolutionary stages, quasi-stellar objects, and galaxies can be separated.
Yonsei Evolutionary Population Synthesis (YEPS) Model. III. Surface Brightness Fluctuation of Normal and Helium-enhanced Simple Stellar Populations
Authors: Chung Chul , Yoon Suk-Jin , Cho Hyejeon , Lee Sang-Yoon , Lee Young-Wook 
Published: October 2020

Abstract
We present an evolutionary population synthesis model of the surface brightness fluctuation (SBF) for normal and He-enriched simple stellar populations (SSPs). While our SBF model for the normal He population agrees with other existing models, the He-rich population, containing hotter horizontal branch stars and brighter red clump stars than the normal He population, entails a substantial change in the SBF of SSPs. We show that the SBF magnitudes are affected by He-rich populations at least ∼0.3 mag even in I- and near-infrared bands at given colors, from which the SBF-based distances are often derived. Due to uncertainties both in observations and models, however, the SBFs of Galactic globular clusters and early-type galaxies do not allow verifying the He-enriched model. We propose that when combined with independent metallicity and age indicators such as Mg2 and Hβ, the UV and optical SBFs can readily detect underlying He-rich populations in unresolved stellar systems at a distance out to ≳20 Mpc. A full set of the spectro-photometric and SBF data for SSPs from the Yonsei Evolutionary Population Synthesis (YEPS) model is available for download at http://cosmic.yonsei.ac.kr/YEPS.htm.
Spectroscopic Classification of Six Cataclysmic Variables with the Liverpool Telescope
Authors: Keeble J. A. , Copperwheat C. M. 
Published: October 2020

Abstract
This paper presents classification spectroscopy of 6 cataclysmic variables obtained with the Liverpool Telescope. These objects were discovered and identified as likely dwarf novae by the Gaia Alerts or ASAS-SN transient surveys.
A Layered Approach to Robust Determination of Asteroseismic Parameters
Authors: Elsworth Yvonne , Themeßl Nathalie , Hekker Saskia , Chaplin William 
Published: October 2020

Abstract
We describe here a layered approach to the robust determination of the broad characteristics of the asteroseismic signal from red-giant stars. No single stringent test can exclude all false results. The use of multiple, weak tests not only provides robust results but also avoids over-constraining the parameter space.
Towards Community Collections Management
Authors: Smith Vincent , Dupont Steen , Woodburn Matt 
Published: October 2020

Collections Management Systems (CMS) are central to the operation of many natural science collections. Over the past few decades, these have evolved from simple tables and databases recording the contents of our collections, to take on multiple roles supporting complex business processes and information management needs within our organisations. These new functional demands have often outpaced the technical development of these systems and organisational capacity to sustain them. Furthermore, their contents essentially remain institutional silos, managed and controlled by single institutions, despite servicing data and a scientific mission that is shared across the global community.
The Natural History Museum, London (NHM) has recently embarked on a journey, working with peer institutions and external consultants, to develop a platform-agnostic set of requirements for a sustainable, scalable and interoperable CMS. The vision of a highly efficient, more flexible and connected solution that can engage with other collections-based organisations and stakeholders is not unique to the NHM, and working with others, including the developers of other CMS, we seek to generate a better understanding of shared collection management business processes, data and data models.
To achieve these goals, a dedicated year-long programme has been formed to address the many facets of a collections management system specification (requirements, processes, standards, models and compliance), and to engage the landscape of internal and external peers, stakeholders and CMS providers.
In this presentation, we will provide some background to explain how the NHM has arrived in its current position and discuss our vision for building on the discussion around existing standards, interoperability and data access. We will summarise the programme’s structure and plans, report on the progress of the first few months, and highlight any challenges encountered and solutions delivered.
Presbyopia Correction in Astigmatic Eyes Using a Toric Trifocal Intraocular Lens With Quadrifocal Technology
Authors: Kohnen Thomas , Lwowski Christoph , Hinzelmann Lisa , Ahmad Wasim , Petermann Kerstin , Hemkeppler Eva , Pawlowicz Katarzyna , Böhm Myriam 
Published: October 2020

PURPOSE:
To evaluate the visual performance after bilateral implantation of a toric diffractive aspheric multifocal intraocular lens (IOL) with a +2.17 diopters (D) (60 cm) intermediate and a +3.25 D (40 cm) addition (add) power.

METHODS:
This prospective single-arm study was conducted at the Department of Ophthalmology, Goethe University, Frankfurt, Germany. Twenty-five patients (50 eyes) received bilateral implantation of the toric PanOptix IOL (AcrySof IQ PanOptix; Alcon Research LLC) before enrollment. Exclusion criteria were previous ocular surgeries excluding lens surgery and ocular pathologies or corneal abnormalities. Examination at 3 months postoperatively included manifest refraction; monocular and binocular uncorrected distance (UDVA) and distance-corrected (DCVA) visual acuity at 4 m and 80, 60, and 40 cm; and slit-lamp examination. At 3 months postoperatively, monocular and binocular defocus, binocular contrast sensitivity under photopic and mesopic conditions, and optical phenomena, and spectacle independence were evaluated.

RESULTS:

Mean refractive spherical equivalent was 0.12 ± 0.380 D and mean refractive cylinder was −0.21 ± 0.237 D at 3 months postoperatively. A significant decrease in refractive cylinder was observed postoperatively (
P
< .05), with 98% showing a postoperative astigmatism below 0.75 D. Monocular UDVA was better than 0.14 logMAR in all distances. Binocular defocus curve showed peaks at 0.00 D (−0.09 logMAR) and −1.50 and −2.00 D (−0.02 and 0.00 logMAR). The worst values between far (4 m) and near (40 cm) distance were 0.04 logMAR at −1.00 D. Despite some optical phenomena, 92% of patients would choose the same IOL again and recommend it to others.

CONCLUSIONS:
The visual performance of the toric PanOptix IOL showed good visual acuity at all distances; more than 90% achieved a decrease of refractive cylinder below 0.75 D, high patient satisfaction despite some optical phenomena, and high spectacle independence 3 months postoperatively.

[
J Refract Surg
. 2020;36(10):638–644.]
Validation of a Short Form for Health Literacy Assessment Using Talking Touchscreen Technology
Authors: Slesinger Noël C. , Yost Kathleen J. , Choi Seung W. , Hahn Elizabeth A. 
Published: October 2020

Background:
Health literacy is an area of growing research and clinical interest, necessitating short, accurate measures of this complex construct. Health Literacy Assessment Using Talking Touchscreen Technology (Health LiTT) measures prose, document, and quantitative literacy by self-administration on a touchscreen computer.

Objective:
The objective of this study was to assess the validity of a short form of Health LiTT and to identify a meaningful cutoff score for adequate health literacy.

Methods:
A subsample of 137 participants from the Literacy and Cognitive Function among Older Adults study completed a 10-item Health LiTT short form and three interviewer-administered health literacy measures: Test of Functional Health Literacy in Adults (TOFHLA), Rapid Estimate of Adult Literacy in Medicine (REALM), and Newest Vital Sign (NVS). Convergent validity was assessed by correlating scores for all measures, and known-groups validity was assessed by comparing mean Health LITT scores across TOFHLA levels (inadequate, marginal, adequate). Internal consistency reliability was estimated with Cronbach's alpha. A cutoff score for adequate health literacy was established using the TOFHLA cutoff for adequate versus inadequate/marginal health literacy.

Key Results:

Spearman correlations between Health LiTT scores and total TOFHLA, REALM, and NVS scores were 0.65, 0.69, and 0.56, respectively (all
p
< .001). Mean Health LiTT scores were significantly and meaningfully different across inadequate (40.4), marginal (50.1), and adequate (57.1) TOFHLA categories (F = 60.6;
p
< .001). Cronbach's alpha for the Health LiTT short form was .73. A cutoff score of 55 on Health LiTT showed acceptable sensitivity and specificity to identify adequate health literacy.

Conclusions:

This 10-item Health LiTT short form demonstrated excellent convergent and known-groups validity and acceptable internal consistency reliability in older adults. The established cutoff also showed excellent sensitivity and specificity. Validation of other custom Health LiTT short forms with varying items from the bank and computer adaptive test-generated Health LiTT scores is ongoing.

[
HLRP: Health Literacy Research and Practice
. 2020;4(4):e200–e207.]

Plain Language Summary:
This article provides evidence of the need for and psychometric properties of a valid and reliable short form of the flexible, technologically advanced Health Literacy Assessment Using Talking Touchscreen Technology measure, as well as a cutoff score to note adequate versus marginal/inadequate health literacy.
Transcriptomic Profiling of Human Effector and Regulatory T Cell Subsets Identifies Predictive Population Signatures
Authors: Höllbacher Barbara , Duhen Thomas , Motley Samantha , Klicznik Maria M , Gratz Iris K , Campbell Daniel J 
Published: October 2020

Abstract
After activation, CD4+ Th cells differentiate into functionally specialized populations that coordinate distinct immune responses and protect against different types of pathogens. In humans, these effector and memory Th cell subsets can be readily identified in peripheral blood based on their differential expression of chemokine receptors that govern their homeostatic and inflammatory trafficking. Foxp3+ regulatory T (Treg) cells can also be divided into subsets that phenotypically mirror each of these effector populations and share expression of key transcription factors and effector cytokines. In this study, we performed comprehensive transcriptional profiling of 11 phenotypically distinct Th and Treg cell subsets sorted from peripheral blood of healthy individuals. Despite their shared phenotypes, we found that mirror Th and Treg subsets were transcriptionally dissimilar and that Treg cell populations showed limited transcriptional diversity compared with Th cells. We identified core transcriptional signatures shared across all Th and Treg cell populations and unique signatures that define each of the Th or Treg populations. Finally, we applied these signatures to bulk Th and Treg RNA-sequencing data and found enrichment of specific Th and Treg cell populations in different human tissues. These results further define the molecular basis for the functional specialization and differentiation of Th and Treg cell populations and provide a new resource for examining Th and Treg specialization in RNA-sequencing data.
A Chimeric Antigen Receptor That Binds to a Conserved Site on MICA
Authors: Cook W James , Choi Yoonjoo , Gacerez Albert , Bailey-Kellogg Chris , Sentman Charles L 
Published: October 2020

Abstract
The NKG2D ligand MHC class I chain–related protein A (MICA) is expressed on many varieties of malignant cells but is absent from most normal tissues, and thus represents a potential target for chimeric Ag receptor (CAR) T cell–based therapeutics. However, there are more than 100 alleles of MICA, so the ability to target a conserved site is needed for a therapy to be used in most patients. In this study, we describe a fully human anti-MICA CAR created by fusing the single-chain fragment variable B2 to the full length DAP10 protein and the traditional CD3ζ signaling domain. Human T cells expressing the B2 CAR killed MICA-positive tumor cells, produced IFN-γ when in contact with MICA-positive tumor cells or plate-bound MICA protein, and inhibited PANC-1 growth in a mouse xenograft model. To localize B2’s epitope on MICA, we used novel computational methods to model potential binding modes and to design mutational variants of MICA testing these hypotheses. Flow cytometry using a commercial anti-MICA/MICB Ab indicated that the variant proteins were expressed at high levels on transduced P815 cell lines. One variant protein (R38S/K40T/K57E) showed reduced staining with a B2-IgG1 fusion protein compared with controls and did not induce IFN-γ production by human T cells expressing the B2 CAR. These results show antitumor activity of MICA-specific CAR T cells and indicate an essential role for a conserved site in the exposed loop involving aa 38–57 of MICA. This study describes a novel MICA-specific CAR and discusses its potential use as a cancer therapeutic.
Evaluation of antiangiogenic and antiproliferative potential of ethanolic extracts of Andrographis echioides using in vitro and in ovo assays
Authors: Muralidharan Karthiga , Kumaravelu Punnagai , David Darling Chellathai 
Published: October 2020

Introduction:

Andrographis echioides is a prevalently used medicinal herb in South Asian countries. Scientific researches with the extracts of A. echioides revealed its antipyretic, anti-inflammatory, antimicrobial, ulceroprotective, and hepatoprotective properties. This study was done to elucidate antiproliferative and antiangiogenic potential of ethanolic extracts of A. echioides (EEAE) by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-tetrazolium bromide (MTT) assay and chorioallantoic membrane (CAM) assay.

Materials and Methods:
EEAE was prepared using Soxhlet apparatus with ethanol after being sun-dried and powdered. MCF 7 (human invasive breast ductal carcinoma) cell lines retaining attributes of differentiated mammary epithelium with both estrogen and progesterone receptors were treated with EEAE, and antiproliferative effect was seen using Mosmann method of MTT assay using 5-fluorouracil (5-FU) as a comparator. The evaluation of antiangiogenic potential of EEAE was done by comparing mean vessel density (MVD) in chick CAM after treatment with EEAE, thalidomide, and vascular endothelial growth factor (VEGF) using CAM assay, an in ovo assay.

Results:
EEAE displayed antiproliferative activity from low to high concentrations with MTT assay. The IC 50 of EEAE and 5-FU was 62.5 and 15.6 μg/ml, respectively (P < 0.05). The exhibition of its antiangiogenic activity increased proportionately with increasing concentration. VEGF increased MVD by 45.94%; thalidomide decreased it by 53.76%. There was a decrease of MVD by 5.91%, 20.46%, and 35.95% at concentrations of 25, 50, and 100 μg of EEAE, respectively.

Conclusion:
EEAE possessed significant antiangiogenic and antiproliferative activity, making them a promising substrate in the development of a novel anticancer drug and can be successfully used in the therapy of various cancers after establishment of the anticancer effects in animal models and subsequently in clinical trials.
Epidemiological study of bacterial meningitis in Tunisian children, beyond neonatal age, using molecular methods: 2014-2017
Authors: Haddad-Boubaker Sondes , Lakhal Marwa , Fathallah Cyrine , Mhimdi Samar , Bouafsoun Aida , Kechrid Amel , Smaoui Hanen 
Published: October 2020

Background: Since the 1990s, the epidemiology of bacterial meningitis worldwide has changed thanks to vaccination. In Tunisia, the main causative pathogens were Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae serotype b (Hib). Only Hib vaccination was available during our study period.
Objectives: We performed a laboratory case report based-study of suspected bacterial meningitis in Northern Tunisia from January 2014 to June 2017.
Methods: CSF samples obtained from children beyond neonatal age with suspicion of meningitis were tested by two real time PCRs, targeting pneumococcus, meningococcus and Hib, and conventional methods.
Results: Using real-time PCR, 63 were positive including ten supplementary cases compared to conventional methods. A general decrease of bacterial meningitis cases was demonstrated comparing to previous data. Pneumococcus was predominant (69.84%) followed by meningococcus (28.57%) and Hib (1.59%). The main serotypes were 14, 19F, 6B and 23F for pneumococcus and serogroup B for meningococcus. Most cases occurred during cold season and children under one year were the most affect- ed by bacterial meningitis.
Conclusion: Our study suggests the predominance of pneumococcal cases. It may provide valuable data on meningitis epidemiology before the introduction of pneumococcal vaccine, which may be useful for future evaluation.
Keywords: Bacterial meningitis; children; Tunisia; PCR.
Detection, quantification and genotype distribution of HCV patients in Lahore, Pakistan by real-time PCR
Authors: Umer Khan Muhammad , Sadia Haleema , Irshad Asma , Amin Baig Atif , Ashiq Sana , Zahid Beenish , Sheikh Rozeena , Roshan Sadia , Ali Azam , Shamas Shazia , Ahmed Bhinder Munir , Ahmad Rais 
Published: October 2020

Background: Hepatitis C virus (HCV) is considered as “Viral Time Bomb” suggested by the World Health Organization and if it is not treated timely, it will lead towards cirrhosis and hepatocellular carcinoma (HCC).
Objective: The purpose of the present research is to study possible risk factors, frequent genotypes of HCV and its asso- ciation with different age groups.
Methods: Suspected blood samples from HCV patients were collected from different hospitals of Lahore, Pakistan. Out of 1000 HCV suspected samples, 920 samples were found HCV positive detected by Anti-HCV ELISA, CobasR. kit. The quantification of HCV load was determined by HCV quantification kit and LINEAR ARRAY KIT (Roche) was used for genotype determination by Real-Time PCR (ABI). Statistical analysis was done by using Microsoft Excel.
Results: Out of 920 subjects, 77 subjects (8.4%) were false positive and they were not detected by nested PCR. Three PCR positive samples were untypeable. Genotype 3 was predominant in Lahore which was 83.5%, whereas type 1 and 2 were 5.1% and 0.7% respectively. There were also mixed genotypes detected, 1 and 3 were 0.4%, 2 and 3 were 1.41% and 3 and 4 were 0.2% only. Male were more infected of HCV in the age <40 years and females >40years.
Conclusion: The major risk factor for HCV transmission is by use of unsterilized razors/blades. It is necessary to spread awareness among the general population of Pakistan about HCV transmission risk factors. Regular physical examination at least once a year is recommended, so that early detection of HCV could be done.
Keywords: Hepatitis C virus; hepatocellular carcinoma; quantification; genotype; real-time PCR.
Letter to the Editor: Dengue fever in the Corpus Hippocraticum
Authors: E Mazokopakis Elias 
Published: October 2020

Dengue fever (DF) is a globally significant infection which causes a range of severe and non-severe clinical manifestations. It is transmitted by mosquitoes of the Aedes genus (primarily Aedes aegypti, but also Aedes al- bopictus). In this letter, a possible DF epidemic on Thasos Island in Greece, which is described in the Book of Epidemics I of the Corpus Hippocraticum, is presented and analyzed. To my knowledge, it is the first report of DF in the history of medicine.
Keywords: Dengue fever; Corpus Hippocraticum.
Determinants of early marriage among female children in Amhara Region, Ethiopia
Authors: Kassa Tekile Abay , Abate Woya Ashenafi , Wakjira Basha Garoma 
Published: October 2020

Background: Early Marriage is one of the global problems that undermine the personal development and the rights of women seriously. It is delicate among the developing countries such as Ethiopia. It has major consequences for public health, national security, social development, human rights, economic development, and gender equality.
Methods: The analyzed data were obtained from the 2016 EDHS and 1120 samples were considered in this analysis. Both bivariate and multivariable binary logistic regression model were used to identify the determinants of early marriage practice.
Results: The prevalence of early marriage practice was 48.57% in the study area. The odds of early marriage practice were 2.04(AOR=2.04, 95% CI: 1.88, 2.45) times higher among rural residents compared to urban. The odds of early marriage practice was 0.94(AOR=0.94, 95%CI: 0.57, 1.98) times lower among women who had primary education compared to un- educated women. Those who did not know the legal marital age were 1.61(AOR=1.61, 95%CI: 1.26, 2.07) times more likely to practice early marriage compared to parents who knew the legal marital age.
Conclusion: Education level, family monthly income, residence, literacy level and knowledge of legal marital were signifi- cant determinants of early marriage practice.
Keywords: Early Marriage; Female; Amhara Region; Ethiopia.