bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microaggressions towards people affected by mental health problems: a scoping review
Authors: Barber S. , Gronholm P. C. , Ahuja S. , Rüsch N. , Thornicroft G. 
Published: December 2019

Abstract

Aims
This review aims to understand the scope of the literature regarding mental health-related microaggressions towards people affected by mental health problems.

Methods
A scoping review was conducted to explore this question. Four electronic health-oriented databases were searched alongside Google Scholar. As per scoping review principles, the inclusion criteria were developed iteratively. The results of included studies were synthesised using a basic narrative synthesis approach, utilising principles of thematic analysis and thematic synthesis where appropriate.

Results
A total of 1196 records were identified, of which 17 met inclusion criteria. Of these, 12 were peer-reviewed journal articles, three were research degree theses and two were book chapters. Six included empirical studies were qualitative, four were quantitative and two employed a mixed-methods design. Within these, five qualitative studies aimed to describe the nature of mental health microaggressions experienced by people with mental health problems. Themes identified in a thematic synthesis of these five studies included stereotypes about mental illness, invalidating peoples' experience and blaming people with mental illness for their condition. The included publications informed on the perpetration of mental health microaggressions by family, friends, health professionals and social workers. In addition, two studies created scales, which were then used in cross-sectional surveys of the general public and community members to assess characteristics, such as right-wing political views, associated with endorsement of mental health microaggressions. A consensus definition of microaggressions emerged from the included studies: microaggressions are brief, everyday slights, snubs or insults, that may be subtle or ambiguous, but communicate a negative message to a target person based on their membership of a marginalised group, in this case, people affected by mental illness.

Conclusions
The study of mental health microaggressions is an emerging, heterogeneous field, embedded in the wider stigma and discrimination literature. It has been influenced by earlier work on racial microaggressions. Both can be ambiguous and contradictory, which creates difficulty defining the boundaries of the concept, but also underpins the key theoretical basis for the negative impact of microaggressions. Mental illness is a more concealable potential type of identity, so it follows that the reported perpetrators of microaggressions are largely friends, family and professionals. This has implications for intervening to reduce the impact of microaggressions. There are several challenges facing research in this area, and further work is needed to understand the impact of mental health microaggressions on people affected by mental health problems.
High-resolution MEMS inertial sensor combining large-displacement buckling behaviour with integrated capacitive readout
Authors: El Mansouri Brahim , Middelburg Luke M. , Poelma René H. , Zhang Guo Qi , van Zeijl Henk W. , Wei Jia , Jiang Hui , Vogel Johan G. , van Driel Willem D. 
Published: December 2019

AbstractCommercially available gravimeters and seismometers can be used for measuring Earth’s acceleration at resolution levels in the order of $${\mathrm{ng}}/\sqrt {\mathrm{Hz}}$$

ng
∕

Hz

(where g represents earth’s gravity) but they are typically high-cost and bulky. In this work the design of a bulk micromachined MEMS device exploiting non-linear buckling behaviour is described, aiming for $${\mathrm{ng}}/\sqrt {\mathrm{Hz}}$$

ng
∕

Hz

resolution by maximising mechanical and capacitive sensitivity. High mechanical sensitivity is obtained through low structural stiffness. Near-zero stiffness is achieved through geometric design and large deformation into a region where the mechanism is statically balanced or neutrally stable. Moreover, the device has an integrated capacitive comb transducer and makes use of a high-resolution impedance readout ASIC. The sensitivity from displacement to a change in capacitance was maximised within the design and process boundaries given, by making use of a trench isolation technique and exploiting the large-displacement behaviour of the device. The measurement results demonstrate that the resonance frequency can be tuned from 8.7 Hz–18.7 Hz, depending on the process parameters and the tilt of the device. In this system, which combines an integrated capacitive transducer with a sensitivity of 2.55 aF/nm and an impedance readout chip, the theoretically achievable system resolution equals 17.02 $${\mathrm{ng}}/\sqrt {\mathrm{Hz}}$$

ng
∕

Hz

. The small size of the device and the use of integrated readout electronics allow for a wide range of practical applications for data collection aimed at the internet of things.
Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma
Authors: Smadbeck James , Peterson Jess F. , Pearce Kathryn E. , Pitel Beth A. , Figueroa Andrea Lebron , Timm Michael , Jevremovic Dragan , Shi Min , Stewart A. Keith , Braggio Esteban , Riggs Daniel L. , Bergsagel P. Leif , Vasmatzis George , Kearney Hutton M. , Hoppman Nicole L. , Ketterling Rhett P. , Kumar Shaji , Rajkumar S. Vincent , Greipp Patricia T. , Baughn Linda B. 
Published: December 2019

AbstractFluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since most translocations in MM involve a position effect with heterogeneous breakpoints, we hypothesize that FISH has the potential to miss translocations involving these regions. We evaluated 70 bone marrow samples from patients with plasma cell dyscrasia by FISH and whole-genome mate-pair sequencing (MPseq). Thirty cases (42.9%) displayed at least one instance of discordance between FISH and MPseq for each primary and secondary abnormality evaluated. Nine cases had abnormalities detected by FISH that went undetected by MPseq including 6 tetraploid clones and three cases with missed copy number abnormalities. In contrast, 19 cases had abnormalities detected by MPseq that went undetected by FISH. Seventeen were MYC rearrangements and two were 17p deletions. MPseq identified 36 MYC abnormalities and 17 (50.0% of MYC abnormal group with FISH results) displayed a false negative FISH result. MPseq identified 10 cases (14.3%) with IgL rearrangements, a recent marker of poor outcome, and 10% with abnormalities in genes associated with lenalidomide response or resistance. In summary, MPseq was superior in the characterization of rearrangement complexity and identification of secondary abnormalities demonstrating increased clinical value compared to FISH.
CircRNA hsa_circ_0074834 promotes the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by acting as a ceRNA for miR-942-5p
Authors: Ouyang Zhengxiao , Tan Tingting , Zhang Xianghong , Wan Jia , Zhou Yanling , Jiang Guangyao , Yang Daishui , Guo Xiaoning , Liu Tang 
Published: December 2019

AbstractBone tissue has a strong ability to repair itself. When treated properly, most fractures will heal well. However, some fractures are difficult to heal. When a fracture does not heal, it is called nonunion. Approximately, 5% of all fracture patients have difficulty healing. Because of the continuous movement of the fracture site, bone nonunion is usually accompanied by pain, which greatly reduces the quality of life of patients. Bone marrow mesenchymal stem cells (BMSCs) play an important role in the process of nonunion. Circular RNAs (circRNAs) are a unique kind of noncoding RNA and represent the latest research hotspot in the RNA field. At present, no studies have reported a role of circRNAs in the development of nonunion. After isolation of BMSCs from patients with nonunion, the expression of circRNAs in these cells was detected by using a circRNA microarray. Alkaline phosphatase and Alizarin red staining were used to detect the regulation of osteogenic differentiation of BMSCs by hsa_circ_0074834. The target gene of hsa_circ_0074834 was detected by RNA pull-down and double-luciferase reporter assay. The ability of hsa_circ_0074834 to regulate the osteogenesis of BMSCs in vivo was tested by heterotopic osteogenesis and single cortical bone defect experiments. The results showed that the expression of hsa_circ_0074834 in BMSCs from patients with nonunion was decreased. Hsa_circ_0074834 acts as a ceRNA to regulate the expression of ZEB1 and VEGF through microRNA-942-5p. Hsa_circ_0074834 can promote osteogenic differentiation of BMSCs and the repair of bone defects. These results suggest that circRNAs may be a key target for the treatment of nonunion.
RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis—an updated review
Authors: Dubois Fatéméh , Bergot Emmanuel , Zalcman Gérard , Levallet Guénaëlle 
Published: December 2019

AbstractThe Ras association domain family protein1 isoform A (RASSF1A) is a well-known tumor-suppressor protein frequently inactivated in various human cancers. Consistent with its function as a molecular scaffold protein, referred to in many studies, RASSF1A prevents initiation of tumorigenesis, growth, and dissemination through different biological functions, including cell cycle arrest, migration/metastasis inhibition, microtubular stabilization, and apoptosis promotion. As a regulator of key cancer pathways, namely Ras/Rho GTPases and Hippo signaling without ignoring strong interaction with microtubules, RASSF1A is indeed one of the guardians of cell homeostasis. To date, as we approach the two decade anniversary of RASSF1A’s discovery, this review will summarize our current knowledge on the RASSF1A key interactions as a tumor suppressor and discuss their impact on cell fate during carcinogenesis. This could facilitate a deeper understanding of tumor development and provide us with new strategies in cancer treatment by targeting the RASSF1A pathway.
Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma
Authors: Dong Zhiming , Li Shengmian , Wu Xuan , Niu Yunfeng , Liang Xiaoliang , Yang Liu , Guo Yanli , Shen Supeng , Liang Jia , Guo Wei 
Published: December 2019

AbstractNatural antisense lncRNAs can interfere with their corresponding sense transcript to elicit concordant or discordant regulation. LncRNA ZNF667-AS1 and its sense gene ZNF667 were found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues by RNA sequencing; however, the exact roles of both genes in ESCC occurrence and development have not been clarified. This study was to investigate the expression patterns, epigenetic inactivation mechanisms, function, and prognostic significance of ZNF667-AS1 and ZNF667 in ESCC tumorigenesis. Frequent downregulation of ZNF667-AS1 and ZNF667 was detected in esophageal cancer cells and ESCC tissues. The expression levels of ZNF667-AS1 and ZNF667 were significantly reversed by treatment with 5-Aza-dC and TSA in esophageal cancer cell lines. The CpG sites hypermethylation within proximal promoter influenced the binding ability of transcription factor E2F1 to the binding sites and then affected the transcription and expression of ZNF667-AS1 and ZNF667. Overexpression of ZNF667-AS1 and ZNF667 suppressed the viability, migration, and invasion of esophageal cancer cells in vitro. Overexpression of ZNF667-AS1 increased mRNA and protein expression level of ZNF667. ZNF667-AS1 interacts with and recruits TET1 to its target gene ZNF667 and E-cadherin to hydrolyze 5′-mc to 5′-hmc and further activates their expression, meanwhile, ZNF667-AS1 also interacts with UTX to decrease histone H3K27 tri-methylation to activate ZNF667 and E-cadherin expression. Furthermore, ZNF667-AS1 or ZNF667 expression and promoter methylation status were correlated with ESCC patients’ survival. Thus, these findings suggest that ZNF667-AS1 and ZNF667 may act as tumor suppressors and may serve as potential targets for antitumor therapy.
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
Authors: Shen Shensi , Faouzi Sara , Bastide Amandine , Martineau Sylvain , Malka-Mahieu Hélène , Fu Yu , Sun Xiaoxiao , Mateus Christine , Routier Emilie , Roy Severine , Desaubry Laurent , André Fabrice , Eggermont Alexander , David Alexandre , Scoazec Jean-Yves , Vagner Stéphan , Robert Caroline 
Published: December 2019

AbstractCancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel with drug sensitivity. Although this process is associated with a global reduction in protein synthesis, a subset of mRNAs undergoes an increased efficiency in translation. Inhibiting the eIF4A RNA helicase, a component of the eIF4F translation initiation complex, abrogates this selectively increased translation and is lethal to persister cells. Translation remodelling in persister cells coincides with an increased N6-methyladenosine modification in the 5′-untranslated region of some highly translated mRNAs. Combination of eIF4A inhibitor with BRAF and MEK inhibitors effectively inhibits the emergence of persister cells and may represent a new therapeutic strategy to prevent acquired drug resistance.
Classification of mouse B cell types using surfaceome proteotype maps
Authors: van Oostrum Marc , Müller Maik , Klein Fabian , Bruderer Roland , Zhang Hui , Pedrioli Patrick G. A. , Reiter Lukas , Tsapogas Panagiotis , Rolink Antonius , Wollscheid Bernd 
Published: December 2019

AbstractSystem-wide quantification of the cell surface proteotype and identification of extracellular glycosylation sites is challenging when samples are limited. Here, we miniaturize and automate the previously described Cell Surface Capture (CSC) technology, increasing sensitivity, reproducibility and throughput. We use this technology, which we call autoCSC, to create population-specific surfaceome maps of developing mouse B cells and use targeted flow cytometry to uncover developmental cell subpopulations.
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
Authors:   Malaria Genomic Epidemiology Network, Band Gavin , Le Quang Si , Clarke Geraldine M. , Kivinen Katja , Hubbart Christina , Jeffreys Anna E. , Rowlands Kate , Leffler Ellen M. , Jallow Muminatou , Conway David J. , Sisay-Joof Fatoumatta , Sirugo Giorgio , d’Alessandro Umberto , Toure Ousmane B. , Thera Mahamadou A. , Konate Salimata , Sissoko Sibiri , Mangano Valentina D. , Bougouma Edith C. , Sirima Sodiomon B. , Amenga-Etego Lucas N. , Ghansah Anita K. , Hodgson Abraham V. O. , Wilson Michael D. , Enimil Anthony , Ansong Daniel , Evans Jennifer , Ademola Subulade A. , Apinjoh Tobias O. , Ndila Carolyne M. , Manjurano Alphaxard , Drakeley Chris , Reyburn Hugh , Phu Nguyen Hoan , Quyen Nguyen Thi Ngoc , Thai Cao Quang , Hien Tran Tinh , Teo Yik Ying , Manning Laurens , Laman Moses , Michon Pascal , Karunajeewa Harin , Siba Peter , Allen Steve , Allen Angela , Bahlo Melanie , Davis Timothy M. E. , Simpson Victoria , Shelton Jennifer , Spencer Chris C. A. , Busby George B. J. , Kerasidou Angeliki , Drury Eleanor , Stalker Jim , Dilthey Alexander , Mentzer Alexander J. , McVean Gil , Bojang Kalifa A. , Doumbo Ogobara , Modiano David , Koram Kwadwo A. , Agbenyega Tsiri , Amodu Olukemi K. , Achidi Eric , Williams Thomas N. , Marsh Kevin , Riley Eleanor M. , Molyneux Malcolm , Taylor Terrie , Dunstan Sarah J. , Farrar Jeremy , Mueller Ivo , Rockett Kirk A. , Kwiatkowski Dominic P. 
Published: December 2019

AbstractThe human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as ~23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association inATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on the genetic determinants of malaria resistance in diverse populations.
Deglacial water-table decline in Southern
California recorded by noble gas isotopes
Authors: Seltzer Alan M. , Ng Jessica , Danskin Wesley R. , Kulongoski Justin T. , Gannon Riley S. , Stute Martin , Severinghaus Jeffrey P. 
Published: December 2019

AbstractConstraining the magnitude of past hydrological change
may improve understanding and predictions of future shifts in water
availability. Here we demonstrate that water-table depth, a
sensitive indicator of hydroclimate, can be quantitatively
reconstructed using Kr and Xe isotopes in groundwater. We present
the first-ever measurements of these dissolved noble gas isotopes in
groundwater at high precision (≤0.005‰
amu−1; 1σ), which reveal
depth-proportional signals set by gravitational settling in soil air
at the time of recharge. Analyses of California groundwater
successfully reproduce modern groundwater levels and indicate a
17.9 ± 1.3 m (±1 SE) decline in water-table depth in Southern
California during the last deglaciation. This hydroclimatic
transition from the wetter glacial period to more arid Holocene
accompanies a surface warming of 6.2 ± 0.6 °C (±1 SE). This new
hydroclimate proxy builds upon an existing paleo-temperature
application of noble gases and may identify regions prone to future
hydrological change.
Millimetre-long transport of photogenerated carriers in topological insulators
Authors: Hou Yasen , Wang Rui , Xiao Rui , McClintock Luke , Clark Travaglini Henry , Paulus Francia John , Fetsch Harry , Erten Onur , Savrasov Sergey Y. , Wang Baigeng , Rossi Antonio , Vishik Inna , Rotenberg Eli , Yu Dong 
Published: December 2019

AbstractExcitons are spin integer particles that are predicted to condense into a coherent quantum state at sufficiently low temperature. Here by using photocurrent imaging we report experimental evidence of formation and efficient transport of non-equilibrium excitons in Bi2-xSbxSe3 nanoribbons. The photocurrent distributions are independent of electric field, indicating that photoexcited electrons and holes form excitons. Remarkably, these excitons can transport over hundreds of micrometers along the topological insulator (TI) nanoribbons before recombination at up to 40 K. The macroscopic transport distance, combined with short carrier lifetime obtained from transient photocurrent measurements, indicates an exciton diffusion coefficient at least 36 m2 s−1, which corresponds to a mobility of 6 × 104 m2 V−1 s−1 at 7 K and is four order of magnitude higher than the value reported for free carriers in TIs. The observation of highly dissipationless exciton transport implies the formation of superfluid-like exciton condensate at the surface of TIs.
Japanese encephalitis vaccine-specific envelope protein E138K mutation does not attenuate virulence of West Nile virus
Authors: Kaiser Jaclyn A. , Luo Huanle , Widen Steven G. , Wood Thomas G. , Huang Claire Y-H. , Wang Tian , Barrett Alan D. T. 
Published: December 2019

AbstractWest Nile (WNV) and Japanese encephalitis viruses (JEV) are closely related, mosquito-borne neurotropic flaviviruses. Although there are no licensed human vaccines for WNV, JEV has multiple human vaccines, including the live, attenuated vaccine SA14-14-2. Investigations into determinants of attenuation of JE SA14-14-2 demonstrated that envelope (E) protein mutation E138K was crucial to the attenuation of mouse virulence. As WNV is closely related to JEV, we investigated whether or not the E-E138K mutation would be beneficial to be included in a candidate live attenuated WNV vaccine. Rather than conferring a mouse attenuated phenotype, the WNV E-E138K mutant reverted and retained a wild-type mouse virulence phenotype. Next-generation sequencing analysis demonstrated that, although the consensus sequence of the mutant had the E-E138K mutation, there was increased variation in the E protein, including a single-nucleotide variant (SNV) revertant to the wild-type glutamic acid residue. Modeling of the E protein and analysis of SNVs showed that reversion was likely due to the inability of critical E-protein residues to be compatible electrostatically. Therefore, this mutation may not be reliable for inclusion in candidate live attenuated vaccines in related flaviviruses, such as WNV, and care must be taken in translation of attenuating mutations from one virus to another virus, even if they are closely related.
The heterogeneity and change in the urban structure of metropolitan areas in the United States, 1990–2010
Authors: Leyk Stefan , Balk Deborah , Jones Bryan , Montgomery Mark R. , Engin Hasim 
Published: December 2019

AbstractWhile the population of the United States has been predominantly urban for nearly 100 years, periodic transformations of the concepts and measures that define urban places and population have taken place, complicating over-time comparisons. We compare and combine data series of officially-designated urban areas, 1990–2010, at the census block-level within Metropolitan Statistical Areas (MSAs) with a satellite-derived consistent series on built-up area from the Global Human Settlement Layer to create urban classes that characterize urban structure and provide estimates of land and population. We find considerable heterogeneity in urban form across MSAs, even among those of similar population size, indicating the inherent difficulties in urban definitions. Over time, we observe slightly declining population densities and increasing land and population in areas captured only by census definitions or low built-up densities, constrained by the geography of place. Nevertheless, deriving urban proxies from satellite-derived built-up areas is promising for future efforts to create spatio-temporally consistent measures for urban land to guide urban demographic change analysis.