bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to Pilates following hip arthroscopy for treatment of femoroacetabular impingement syndrome
Authors: Keating Timothy C , Chahla Jorge , Beck Edward C , Riff Andrew J , Clapp Ian M , Jan Kyleen , Nho Shane J 
Published: October 2019

AbstractThe Pilates Method is a common exercise program which focuses on strength, flexibility and control of the body. While the effects of Pilates have been shown to benefit, limited research has investigated its effect on patients with symptomatic femoroacetabular impingement syndrome (FAIS). As such, the purpose of this study was to examine the rate of return to Pilates following hip arthroscopy after undergoing hip arthroscopy for FAIS. The study evaluated consecutive patients who identified themselves as participating in Pilates and had undergone hip arthroscopy for the treatment of FAIS by a single fellowship-trained surgeon between 2012 and 2015 were reviewed. Demographic data, baseline physical examination, imaging, pre- and postoperative patient-reported outcome scores at a minimum of 2-years following surgery as well as a Pilates-specific questionnaire were assessed for all patients. A total of 25 patients (all female) with mean age 38 ± 11 years were identified. Preoperatively, 12 patients had discontinued Pilates due to activity-related hip complaints, 11 patients had scaled back involvement, and 2 patients maintained their baseline routine. Postoperatively, 23 of 25 patients (92%) returned to Pilates at an average of 7.7 ± 4.2 months following surgery (range, 3–14 months). Postoperatively, 96% returned to Pilates at the same level or better than preinjury. Preinjury and postoperative involvement in Pilates were comparable (2.2 h v. 1.8 h per week, P = 0.8). Loss of interest and fear of reinjury were the most common reasons for reduced Pilates involvement. All patients had significant improvements in HOS-ADL (pre 56.52 ± 21.6; post 86.1 ± 18.8; P < 0.001), HOS-SS (30.1 ± 20.0, 63.8 ± 34.8; P < 0.001), mHHS scores (57.6 ± 12.8; 79.2 ± 19.6; P < 0.001), and VAS pain (68.8 ± 15.4; 21.4 ± 26.5; P < 0.001). In conclusion, arthroscopic treatment of FAIS in Pilates participants resulted in significant improvements in hip function and predictably high rates of satisfaction.
WTO Dispute Settlement Post 2019: What to Expect?
Authors: Pauwelyn Joost 
Published: October 2019

ABSTRACT
What does the imminent demise of the WTO Appellate Body (AB) mean for the settlement of ongoing and future trade disputes? This editorial discusses two ‘unlikely solutions’, at least in the short term: the US lifts its veto on AB appointments; a WTO organ unlocks the impasse. Appeals pending on 10 December 2019 will most likely be carried-over pursuant to (contested) Rule 15 of the AB Working Procedures. For panel reports released after that date, four main scenarios emerge: (i) appeals ‘into the void’ blocking the panel report, (ii) no appeal ex post, or ex ante no appeal pacts, (iii) Article 25 appeal arbitration, (iv) ‘floating’ panel reports (interim or final), neither adopted, nor appealed/blocked. The transformation from GATT to WTO took half a century. Regular veto rights in the settlement of trade disputes may be back in a matter of months. It is one thing to lose the AB, quite another to return to pre-WTO dispute settlement where panel outcomes are not automatically binding and power relations play a considerably greater role. At the same time, it would be wrong to equate a (temporary?) return to GATT-style dispute settlement with the collapse of a rules-based WTO system.
Otter diet changes in a reservoir during a severe autumn drought
Authors: Martínez-Abraín Alejandro , Santidrián Tomillo Pilar , Veiga Juan 
Published: October 2019

Abstract
Eurasian otters (Lutra lutra) are known to make extensive use of reservoirs in the Iberian Peninsula, where they forage preferentially on small-size fish (10–20 cm). We hypothesized that the usual consumption of small-size fish by otters in reservoirs is not due to prey size preference, but rather to a higher level of difficulty in capturing larger prey. We studied otter diet in a reservoir that experienced an abrupt drop in stored water caused by an unusually severe drought. We compared relative prey size, hunting success, and diving times between the year of the drought (2017) and two standard rainfall years (2015 and 2016). Otters ate a similar proportion of small and large fish during the drought instead of predominantly eating small fish. Mean diving time during the drought was similar to that of the standard climatic years, indicating a similar physiological cost of capture between small and large fish. Otters had higher hunting success in the drought year (89%) than in the standard years (63%) regardless of prey size. This suggests a higher level of catchability of both fish size classes during the drought as the water level was lower. Results suggest that the usual consumption of small-sized fish by otters in reservoirs could not be related to preference or relative abundance but rather to the difficulty of capturing large-size fish when water levels are high.
Denosumab Therapy Obscures Histological Features of Giant Cell Tumor of Bone
Authors: Gilani Ahmed , Kleinschmidt-DeMasters Bette K 
Published: October 2019

Abstract
Giant cell tumor (GCT) of bone is a locally aggressive tumor with low metastatic potential, usually originating in long bones. Numerous spinal examples have been reported and thus GCTs can be encountered by neuropathologists. We describe a 69-year-old man with more than a 10-year history of GCT primary to the femur that had recently metastasized to the occipital skull bone. The patient had been receiving denosumab, an adjuvant therapy for GCT, prior to the metastasis. Review of the histological features of the original primary tumor in the femur showed archetypal features of GCT, but the posttreatment occipital skull metastasis showed a predominantly low-to-medium cell density spindle cell tumor with complete depletion of osteoclastic giant cells. Although this effect of the drug is increasingly being recognized by soft tissue pathologists, the current case illustrates the potentially confusing histology of postdenosumab-treated GCT for neuropathologists. The absence of giant cells leads the posttherapy primary or metastatic lesion to show histologic similarity to a multitude of benign and malignant fibro-osseous lesions or spindle cell sarcoma and highlights the importance of eliciting appropriate clinical history.
The use of a centrifuge-free RABiT-II system for high-throughput micronucleus analysis
Authors: Repin Mikhail , Pampou Sergey , Brenner David J , Garty Guy 
Published: October 2019

ABSTRACT
The cytokinesis-block micronucleus (CBMN) assay is considered to be the most suitable biodosimetry method for automation. Previously, we automated this assay on a commercial robotic biotech high-throughput system (RABiT-II) adopting both a traditional and an accelerated micronucleus protocol, using centrifugation steps for both lymphocyte harvesting and washing, after whole blood culturing. Here we describe further development of our accelerated CBMN assay protocol for use on high-throughput/high content screening (HTS/HCS) robotic systems without a centrifuge. This opens the way for implementation of the CBMN assay on a wider range of commercial automated HTS/HCS systems and thus increases the potential capacity for dose estimates following a mass-casualty radiological event.
Interfaces, ephemera, and identity: A study of the historical presentation of digital humanities resources
Authors: Warwick Claire 
Published: October 2019

Abstract
This article reports on a study of interfaces to long-lived digital humanities (DH) resources using an innovative combination of research methods from book history, interface design, and digital preservation and curation to investigate how interfaces to DH resources have changed over time. To do this, we used the Internet Archive’s Wayback machine to investigate the original presentation and all subsequent changes to the interfaces of a small sample of projects. The study addresses the following questions: What can we learn from a study of interfaces to DH material? How have interfaces to DH materials changed over the course of their existence? Do these changes affect the way the resource is used, and the way it conveys meaning? Should we preserve interfaces for future scholarship? We show that a valuable information may be derived from the interfaces of long-lived projects. Visual design can communicate subtle messages about the way the resource was originally conceived by its creators and subsequent changes show how knowledge of user behaviour developed in the DH community. Interfaces provide information about the intellectual context of early digital projects. They can also provide information about the changing place of DH projects in local and national infrastructures, and the way that projects have sought to survive in challenging funding environments.
Enhancing the Capacity of the Australian Health Care Workforce to Support Veterans’ Mental Health: A Collaborative Interdisciplinary Approach
Authors: Gibbs Chris , Murphy Barbara , Hoppe Kate , Clarke Patricia , Ratnaike Deepika , Lovelock Harry 
Published: October 2019

Abstract

Introduction
Military personnel and veterans can have higher rates of mental health problems than the general population, but are no more likely to receive appropriate mental health care. A lack of experience among Australia’s mental health workforce in treating veteran-specific issues has been identified, pointing to a need for strategies to strengthen the workforce capacity. To this end, the Department of Veteran’s Affairs joined with the Mental Health Professionals Network (MHPN) to produce and deliver a series of veteran-specific webinars for health professionals working with military personnel, veterans and their families.

Materials and Method
Five webinars were produced and delivered between August 2016 and July 2017. Each involved a panel of health professionals with content expertise and was facilitated by a nationally recognized expert in veteran mental health. Each webinar was evaluated using an online survey to address whether learning needs were achieved, likely improvements to work practice, and improvements in knowledge of and confidence in treating veteran mental health issues.

Results
Of the 5,127 attendees across the five webinars, registration data was collected for 4,809 (94%) and post-webinar data for 3,334 (70%) of registrants. Of these, over 90% indicated that their learning objectives were achieved, that the content was relevant to their practice, and that their work practices would be improved as a result of their participation. Further, almost three quarters reported increased knowledge and skills, and two-thirds increased confidence in treating veterans’ mental health needs.

Conclusions
The Veterans’ webinar series was effective in engaging a large number and a wide range of professionals working in mental health care in Australia, underscoring the strength of MHPN’s initiatives in terms of scale and reach. With its emphasis on interdisciplinary practice and collaborative care, MHPN is well-placed to continue to support Australia’s mental health workforce.
Evaluation of Systematic Blood Testing at the Time of Recruitment to the Armed Forces: Retrospective Monocentric Study Among 726 French Army Soldiers
Authors: Caré Weniko , Hénard Jessica , Gillard Jonathan , Cremades Serge , Ceppa Franck , Vest Philippe , Foissaud Vincent , Hejl Carine 
Published: October 2019

AbstractIntroductionIn the French armed forces, the biological checkup required during the recruitment process comprises a urinalysis (urinary dipstick), a complete blood count (CBC), and measurement of serum levels of aspartate aminotransferase, alanine aminotransferase, fasting blood glucose, and creatinine. This study aimed to evaluate the benefits of this biological checkup and to determine the most relevant parameters.Materials and MethodsWe conducted a monocentric retrospective study of all standardized and systematically conducted blood tests (CBC and measurement of aspartate aminotransferase, alanine aminotransferase, fasting blood glucose, and creatinine) over a 15-month period among 726 French Army recruits.ResultsThe population included mainly young males (85.4%, mean age 21.6 years). More than half (54.1%) of the blood tests had at least one abnormal parameter, most often concerning the CBC. Anemia occurred in 5.3% of the population and was mostly normocytic. Microcytosis was mostly not associated with anemia (72.3% of cases). Lymphopenia occurred in 20.1% of the population and was mostly mild. Eosinophilia was present in 5.1% of the population and was never severe. Thrombocytopenia occurred in 0.7% of the population and was never severe. Serum levels of aminotransferases were elevated in 8.1% of the population. Fasting plasma glucose averaged 84 mg/dL (SD: 0.07) ranging from 64 to 123 mg/dL, was abnormal in 0.4% of the population, and one case of diabetes was diagnosed. Serum creatinine concentration was elevated in 0.7% of the population.ConclusionCBCs gave useful information but iron deficiency was common and insufficiently detected by this single analysis. Assessing aminotransferase levels without screening for viral hepatitis and systematic measurement of fasting plasma glucose levels did not appear to be efficient. In addition, the only interest in systematic measurement of creatinine serum levels was to obtain a reference level for long-term follow-up. In addition to the urinary dipstick, the systematic biological checkup at recruitment could be limited to a CBC with measurement of plasma ferritin levels and Hepatitis B virus serology, providing that any CBC abnormalities, in particular cytopenia, eosinophilia, and microcytosis, are systematically investigated. For a public health approach, systematic screening for other sexually transmitted infections could be proposed.
The lensing properties of subhaloes in massive elliptical galaxies in sterile neutrino cosmologies
Authors: Despali Giulia , Lovell Mark , Vegetti Simona , Crain Robert A , Oppenheimer Benjamin D 
Published: October 2019

ABSTRACT
We use high-resolution hydrodynamical simulations run with the EAGLE model of galaxy formation to study the differences between the properties of – and subsequently the lensing signal from – subhaloes of massive elliptical galaxies at redshift 0.2, in Cold and Sterile Neutrino (SN) Dark Matter models. We focus on the two 7 keV SN models that bracket the range of matter power spectra compatible with resonantly produced SN as the source of the observed 3.5 keV line. We derive an accurate parametrization for the subhalo mass function in these two SN models relative to cold dark matter (CDM), as well as the subhalo spatial distribution, density profile, and projected number density and the dark matter fraction in subhaloes. We create mock lensing maps from the simulated haloes to study the differences in the lensing signal in the framework of subhalo detection. We find that subhalo convergence is well described by a lognormal distribution and that signal of subhaloes in the power spectrum is lower in SN models with respect to CDM, at a level of 10–80 per cent, depending on the scale. However, the scatter between different projections is large and might make the use of power spectrum studies on the typical scales of current lensing images very difficult. Moreover, in the framework of individual detections through gravitational imaging a sample of ≃30 lenses with an average sensitivity of $M_{\rm {sub}} = 5 \times 10^{7}\, {\rm M}_{\odot}$ would be required to discriminate between CDM and the considered sterile neutrino models.
Løgstrup, Levinas and the Mother: Ethics, Love, and the Relationship to the Other
Authors: Christensen Anne-Marie Søndergaard 
Published: October 2019

Abstract
In this article, I investigate the similarities and differences between the ways we relate to the other in ethics and in love through an engagement with the thinking of K.E. Løgstrup and Emmanuel Levinas. My point of departure will be a reading of a novel by Maja Lucas, Mother (2016), which brings out the important and complicated nature of the relation between ethics and love. My main concern, however, is to investigate how Løgstrup’s and Levinas’s different conceptions of natural love point to differences in their understanding of the ethical relationship to the other.
The changing paradigm of intron retention: regulation, ramifications and recipes
Authors: Monteuuis Geoffray , Wong Justin J L , Bailey Charles G , Schmitz Ulf , Rasko John E J 
Published: October 2019

Abstract
Intron retention (IR) is a form of alternative splicing that has long been neglected in mammalian systems although it has been studied for decades in non-mammalian species such as plants, fungi, insects and viruses. It was generally assumed that mis-splicing, leading to the retention of introns, would have no physiological consequence other than reducing gene expression by nonsense-mediated decay. Relatively recent landmark discoveries have highlighted the pivotal role that IR serves in normal and disease-related human biology. Significant technical hurdles have been overcome, thereby enabling the robust detection and quantification of IR. Still, relatively little is known about the cis- and trans-acting modulators controlling this phenomenon. The fate of an intron to be, or not to be, retained in the mature transcript is the direct result of the influence exerted by numerous intrinsic and extrinsic factors at multiple levels of regulation. These factors have altered current biological paradigms and provided unexpected insights into the transcriptional landscape. In this review, we discuss the regulators of IR and methods to identify them. Our focus is primarily on mammals, however, we broaden the scope to non-mammalian organisms in which IR has been shown to be biologically relevant.
‘Multi-SpaM’: a maximum-likelihood approach to phylogeny reconstruction using multiple spaced-word matches and quartet trees
Authors: Dencker Thomas , Leimeister Chris-André , Gerth Michael , Bleidorn Christoph , Snir Sagi , Morgenstern Burkhard 
Published: October 2019

AbstractWord-based or ‘alignment-free’ methods for phylogeny inference have become popular in recent years. These methods are much faster than traditional, alignment-based approaches, but they are generally less accurate. Most alignment-free methods calculate ‘pairwise’ distances between nucleic-acid or protein sequences; these distance values can then be used as input for tree-reconstruction programs such as neighbor-joining. In this paper, we propose the first word-based phylogeny approach that is based on ‘multiple’ sequence comparison and ‘maximum likelihood’. Our algorithm first samples small, gap-free alignments involving four taxa each. For each of these alignments, it then calculates a quartet tree and, finally, the program ‘Quartet MaxCut’ is used to infer a super tree for the full set of input taxa from the calculated quartet trees. Experimental results show that trees produced with our approach are of high quality.
William of Ockham
Authors: Pelletier Jenny , Roques Magali 
Published: October 2019

William of Ockham (b. c. 1287–d. 1347) is one of the giants of medieval philosophy. He was an innovative and controversial thinker who lived an extraordinarily eventful life. He entered the Franciscan order as a young boy and then studied in Oxford and London, where he composed an extensive body of work on logic, natural philosophy, and theology in accordance with the academic requirements of the time. While waiting to incept as a magister with the right to teach in the faculty of theology at Oxford, he was summoned to the papal court at Avignon in 1324, where some of his doctrines were suspected of being heretical. There, he was drawn into the current political crisis of the day between Pope John XXII and the Franciscan order on the question of who owned the property that the Franciscan order used (buildings, clothing, food, etc.). John XXII argued that use entailed ownership; the Franciscans argued that it did not. Ockham waded into the debate, inaugurating an interest in politics and political philosophy that would occupy him exclusively until his death. Eventually convinced that John XXII was a heretic, Ockham fled Avignon in 1328 in the company of Michael of Cesena and other Franciscan leaders, finding protection at the court of Ludwig of Bavaria, the Holy Roman Emperor. He composed a second body of work on property and property rights, heresy, and the nature, origin, and relationship of temporal and spiritual power. Ockham was excommunicated in 1328 but never officially charged with heresy. Ockham’s body of work is remarkable, and not only because of the abrupt shift in his intellectual and political pursuits. Despite the risk of oversimplification, we can identify certain pervasive tendencies in his thought. He exhibits a general preference for parsimony and privileges minimalism in metaphysics while developing a highly sophisticated analysis of language and logic. He insists on a firm foundation for knowledge in our direct experience of individual and contingent objects. He emphasizes divine omnipotence, simplicity, and freedom, and places human freedom and rationality at the heart of his ethics and politics. Ockham’s reputation as an enfant terrible of the late Middle Ages, whose doctrines were commonly represented as either calamitous or revolutionary, depending on the interpreter, has been substantially revised in the past three decades. A balanced and critical assessment of his thought and position in the history of medieval philosophy nevertheless remains an ongoing project.
Anne Bradstreet
Authors: Thickstun Margaret 
Published: October 2019

Anne Dudley Bradstreet (b. c. 1612–d. 1672) emigrated from England to Massachusetts Bay Colony with her extended family in 1630 and remained there until her death. In 1650 a volume of her poems appeared in England under the title The Tenth Muse Lately Sprung Up in America and attributed to “a Gentlewoman of those parts.” An expanded edition, Several Poems, was published in Boston, Massachusetts, six years after her death. Because she was the first published “American” poet, Bradstreet’s work has always been in the public eye, although assessments of its quality and ideas about which pieces merit attention have fluctuated over time.