bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway
Authors: Xue Yaru , Deng Qiangqiang , Zhang Qingli , Ma Zhenghua , Chen Binfan , Yu Xiaolu , Peng Huige , Yao Sheng , Liu Jia , Ye Yang , Pan Guoyu 
Published: December 2020

AbstractArachidonic acid (AA) signaling pathway is an important constituent of inflammatory processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic inflammation in mice with CCl4-induced acute liver injury. This study aimed to investigate the involvement of arachidonate metabolic cascade in this process. Our results showed CCl4 activated AA metabolism with the evidence of cPLA2 phosphorylation, which was dependent on the MAPK/JNK activation. Pretreatment with JNK inhibitor SU3327 or gigantol abolished the cPLA2 activation, along with the attenuation of liver damage. Besides, gigantol markedly decreased immune cells activation. Metabolomic analysis revealed that gigantol universally reversed the upregulation of major AA metabolites in injured mouse livers induced by CCl4, especially 12-hydroxyeicosatetraenoic acid (12-HETE). Gigantol also decreased the mRNA and protein expression of platelet-, and leukocyte-type 12-lipoxxygenase (LOX) in the liver. Furthermore, pan-LOX inhibitor nordihydroguaiaretic acid (NDGA) and specific 12-LOX inhibitors baicalein and ML351 attenuated the liver injury to the same extent as gigantol. Overall, our study elucidated a comprehensive profile of AA metabolites during hepatic inflammation caused by CCl4, highlighting the role of 12-LOX-12-HETE pathway in this process. And gigantol alleviated liver inflammation partly through inhibiting the JNK/cPLA2/12-LOX pathway.
Counseling Parents at the Time of Diagnosis: Moving Toward Client-Centered Practice
Authors: Luterman David 
Published: December 2020

Purpose
The purpose of this article is to present a client-centered model of counseling that integrates information and personal adjustment counseling. Research has indicated that audiologists are more comfortable with counseling that is information based than with personal adjustment counseling. The prevailing model of diagnosis appears to be the medical model in which, first, a case history is taken, then testing and, finally, counseling. This model lends itself to audiologist as expert and the counseling as a separate entity based on information and advice. Further research has indicated parents retain little of the information provided in the initial examination because of their heightened emotions. This article presents a client-centered model of diagnosis in which information is provided within an emotionally safe context, enabling the parents to express their feelings and have the ability to control the flow of information. The ultimate purpose of a client-centered model is to empower parents by making them active participants in the diagnostic process rather than passive recipients.

Conclusion
The client-centered model has wide implications for the diagnostic process as well as for the training of students.
Social Media and People With Traumatic Brain Injury: A Metasynthesis of Research Informing a Framework for Rehabilitation Clinical Practice, Policy, and Training
Authors: Brunner Melissa , Hemsley Bronwyn , Togher Leanne , Dann Stephen , Palmer Stuart 
Published: December 2020

Purpose
The aim of the study was to investigate the experiences of people with traumatic brain injury (TBI) and rehabilitation professionals in use of social media after TBI.

Design
Metasynthesis of a multilevel mixed-methods research design was used in the study.

Method

A qualitative metasynthesis of (a) evidence in the literature regarding the use of communication technologies and social media after TBI, (b) Twitter data and network analysis, (c) interviews with people with TBI (
n
= 13), (d) focus groups with TBI rehabilitation professionals (
n
= 11), and (e) a review of current guidance on safe use of social media was conducted.

Results
People with TBI adopt a trial-and-error approach to using social media. Their meaningful use and a sense of connection enable them to develop social media mastery. TBI rehabilitation professionals' concerns regarding potential risks associated with using social media might lead them to restrict social media use during rehabilitation.

Conclusions
Access to proactive training in social media use and a supportive network of rehabilitation professionals, family, and friends can enable people with TBI to develop social media mastery through working collaboratively on social media goals. This metasynthesis of research culminates in an evidence-based protocol for assessing and supporting a person with TBI's social media goals to guide clinical practice and future research in the field.
COVID-19 and Speech-Language Pathology Clinical Practice of Voice and Upper Airway Disorders
Authors: Doll Emerald J. , Braden Maia N. , Thibeault Susan L. 
Published: December 2020

Purpose
Evaluation and management of voice and upper airway disorders in adults and children, by speech-language pathologists worldwide, have been significantly altered by the COVID-19 pandemic. Secondary to the pathogenic nature of the virus in the respiratory tract and upper airway, it is essential that speech-language pathologists who specialize in these disorders are knowledgeable of current practices to provide evidence-based care while minimizing viral transmission. Understanding how and when SARS-CoV-2 spreads is critical to the development of effective infection prevention within clinical practices.

Method
We established an evidence-based clinical practice guide for clinicians working with voice and upper airway through a comprehensive evaluation of peer-reviewed journals, non–peer-reviewed manuscripts on preprint servers, national health guidelines, and published and online consensus statements and emerging data. Emphasis was placed on risk mitigation for viral transmission via safe clinical practices, including evaluative procedures, therapy including telehealth, personal protective equipment, room, staffing, and distancing considerations.

Results/Conclusions
While knowledge relevant to viral transmission of SARS-CoV-2 is rapidly evolving, there is a paucity of literature specific to the evaluation and treatment of voice and upper airway disorders. Within these confines and given the potentially significant high risk of infection secondary to the nature of COVID-19, we summarize current considerations and recommend best practices that maximize risk mitigation whereby ensuring patient and provider safety.
Hydrolysis as a basis for processing vegetable waste into bioplastics
Authors: Ilalova Guzel , Safin Ruslan , Mukhametzyanov Shamil , Gazizullina Albina 
Published: December 2020

The greening of processing waste from logging and woodworking industries involves measures to prevent the negative impact of production processes on the natural environment and is enabled by the development of resource-saving techniques that minimize harmful emissions to the environment. These production operations are based on hydrolytic cleavage of glycoside bonds of vegetable biomass polysaccharides with the formation of monosaccharides as the main reaction products.
Despite the wide range of available methods of processing wood into promising materials (heat treatment, pyrolysis, hydrolysis, etc.), one of the most effective methods is to produce sugars by weak acids hydrolysis.
In this regard, the paper describes the technology of high-temperature hydrolysis of pine sawdust with sulfurous acid in order to detect reducing substances (RS) in the hydrolysis residue. The paper considers the effect of sulfurous acid, temperature, and treatment time on the yield of RS.
Frequencies of Genetic Polymorphisms of Clinically Relevant Gene-Drug Pairs in a German Psychiatric Inpatient Population
Authors: Hahn Martina , Müller Daniel J. , Roll Sibylle C. 
Published: December 2020

Abstract
Introduction Genetic variation is known to affect enzymatic activities allowing differentiating various metabolizer types (e. g., slow or rapid metabolizers), in particular CYP2C19 and CYP2D6.
Methods PGx-testing was conducted in adult major depressive disorder inpatients admitted to the Vitos Klinik Eichberg between 11/2016 and 7/2017 (n=108, 57% female). We conducted a two-sided Z-Test (p=0.05) to analyze and compare frequencies of CYP2D6, CYP2C19, CYP3A4, CYP3A5 and CYP2C9 metabolizer groups with other European and psychiatric inpatient cohorts. The HLA-A and –B genes were also analyzed.
Results Non-normal metabolizer status of CYP2D6 were present in 47%. More specifically, 35 % were intermediate, 7% poor and 4% ultra-rapid metabolizers. 68% were CYP2C19 non-normal metabolizers. 8% were ultra-rapid and 31% rapid metabolizers. Notably, only 13% were NM for CYP2C19 and NM for CYP2D6 (activity score of 1 or more). For CYP2C9 we found 16% to be intermediate metabolizers, 1.0% poor metabolizer. CYP3A4 and CYP3A5 genetic polymorphisms were present in 25% and 19% respectively. HLA-B TAG- SNPs for *15:01 was positive in 25 patients, showing the need for different Tag-SNPs in Caucasians. HLA-B *57:01 TAG-SNP was positive in 8% of the patients, HLA-A TAG-SNP for *31:01 in Caucasians was positive in 9%. Z-Test showed statistical significance for our results.
Discussion Our results suggest that our psychiatric inpatients were enriched with genotypes consistent with non-normal drug metabolism compared to reference populations. We therefore conclude that pharmacogenetic testing should be implemented in clinical practice to guide drug therapy.
Risk Factors for Extensively Drug-Resistant Acinetobacter baumannii in Neonatal Patients
Authors: Tekin Recep , Yolbaş İlyas , Bozkurt Fatma , Çevik Saliha , Alay Handan , Özcan Nida , Aktar Fesih , Çolak Habibe 
Published: December 2020

Abstract
Introduction Extensively drug-resistant Acinetobacter baumannii infections (XDRABIs) are significant causes of mortality and morbidity in neonatal patients due to the treatment difficulties and limitations. In the present study, we aimed to evaluate the characteristics and risk factors for XDRABIs acquisition during hospitalization.
Methods We investigated the risk factors of health care-associated infections (HC-AIs) caused by multidrug-resistant A. baumannii in the four neonatal units between January 2008 and December 2018. The patients and the control group's data and culture results were recorded and analyzed on a daily basis.
Results A total of 70 patients infected with XDRABIs and 118 control patients were included in the study. Univariate analysis showed that prematurity, gestation age, birth weight, mechanical ventilation, parenteral nutrition, transfusion, use of glycopeptides, and aminoglycosides were significantly associated with XDRABIs. In the univariate analysis, gestation age, mechanical ventilation, transfusion, parenteral nutrition, use of glycopeptides, carbapenems, and aminoglycosides were significantly associated with mortality. In the multiple logistic regression analysis, gestation age (p = 0.034), transfusion (p < 0.001), and use of glycopeptides (p = 0.019) were determined to be independent predictors of mortality in newborn infants with XDRABIs (R-square = 0.546).
Conclusion Determination of the risk factors, avoiding invasive procedures, rational use of antibiotics will lead to a decrease in the mortality and morbidity rates related to XDRABIs.
Global evidence for ultraviolet radiation decreasing COVID-19 growth rates
Authors: Carleton Tamma , Cornetet Jules , Huybers Peter , Meng Kyle C. , Proctor Jonathan 
Published: December 2020

Significance
There is interest in whether COVID-19 cases respond to environmental conditions. If an effect is present, seasonal changes in local environmental conditions could alter the global spatial pattern of COVID-19 and inform local public health responses. Using a comprehensive global dataset of daily COVID-19 cases and local environmental conditions, we find that increased daily ultraviolet (UV) radiation lowers the cumulative daily growth rate of COVID-19 cases over the subsequent 2.5 wk. Although statistically significant, the implied influence of UV seasonality is modest relative to social distancing policies. Temperature and specific humidity cumulative effects are not statistically significant, and total COVID-19 seasonality remains to be established because of uncertainty in the net effects from seasonally varying environmental variables.
Social contact and speech act strategies in a Chinese study abroad context
Authors: Tang Xiaofei , Taguchi Naoko , Li Shuai 
Published: December 2020

Abstract
This study examined the relationship between reported amounts of social contact and speech act strategies among 70 learners of Chinese enrolled in a study abroad program in Beijing. The participants completed a computer-delivered spoken discourse completion task (spoken DCT) eliciting three speech acts: requests, refusals, and compliment responses. Speech act strategies were compared between two groups of learners who reported different amounts of social contact (high and low social contact) as assessed via a self-report survey. Results showed that both high and low social contact groups favored using similar strategies to achieve the three speech acts. However, the high social contact group produced speech acts in a more sophisticated way: with a wider variety of request strategies, multiple refusal strategies used in combination and more deflecting strategies in compliment responses, compared with the low social contact group. The findings suggest that social contact helped learners expand their pragmalinguistic repertoire and employ more varied speech act strategies.
Sweet cherry pruning fundamentals.
Authors: Long Lynn E. , Lang Gregory A. , Kaiser Clive 
Published: December 2020

Abstract

This chapter focuses on the fundamentals of pruning sweet cherry orchards. The fundamentals of training and pruning contemporary sweet cherry orchards usually incorporate plant materials or techniques that promote: early fruiting for a more rapid return on investment; optimization of light interception and distribution, with minimal intra-canopy shading; greater precision in, and/or simplification of, canopy development for balancing yields with fruit size and quality, as well as ease of teaching to less experienced labor forces; and systematic processes for annual renewal of fruiting wood to maintain consistent yields of high fruit quality as trees age.
Fruit ripening and harvest.
Authors: Long Lynn E. , Lang Gregory A. , Kaiser Clive 
Published: December 2020

Abstract

This chapter provides information on the processes that occur in the sweet cherry fruit during ripening prior to harvest. Some pre-harvest disorders, such as fruit cracking, and their management are presented. Some factors to consider during the harvesting of the fruits are also discussed, along with various harvesting techniques. Some postharvest fruit quality considerations are highlighted and the importance of postharvest temperature and humidity control and safe transport of fruits from the orchard to the packing house are pointed out.
Managing orchard pests.
Authors: Long Lynn E. , Lang Gregory A. , Clive Kaiser 
Published: December 2020

Abstract

This chapter provides information on the various economically important insect and arthropod pests causing damage to cherry production, such as Rhagoletis indifferens, Drosophila suzukii, Choristoneura rosaceana, Tetranychus urticae and Caliroa cerasi, among others. Notes on their life cycle, damage and management methods are also presented.
Judicial Impact and Factual Allegations: How the Supreme Court Changed Civil Procedure through the Plausibility Standard
Authors: Hazelton Morgan L. W. 
Published: December 2020

AbstractResearchers often study the impact of legal change by investigating judges’ decisions and ignoring litigants. Many scholars believe the Supreme Court’s decisions in Twombly and Iqbal increased how specific factual allegations must be to avoid dismissal, but studies generally fail to find an effect. Using text analysis, I find evidence that litigants and their lawyers changed the information they provided after the decisions in certain types of cases. These results call into question prior studies and illustrate the need to consider the behavior of litigants. They also help shed light on issues of access to courts and separation of powers.
Point cloud simplification algorithm based on the feature of adaptive curvature entropy
Authors: Wang Guolin , Wu Lushen , Hu Yun , Song Minjie 
Published: December 2020

Abstract
Considering the diversity of point cloud features, the simplification effects of traditional point cloud simplification algorithms (such as curvature, random and isometry simplification algorithms) are poor. To overcome these drawbacks, a point cloud simplification method based on adaptive curvature entropy is proposed. Points with large curvatures are extracted to construct the initial point cloud boundary by defining a given proportion. The point cloud is clustered using the dichotomy clustering method. Subsequently, a preliminary simplification based on an adaptive random algorithm is performed for each clustered point cloud to reduce the point cloud capacity. The curvature entropy of each clustered point cloud is calculated to remove redundant points and preserve feature points so that the simplified point cloud is eventually obtained. The extracted initial point cloud boundary and simplified point cloud constitute the final simplified result. The classic Stanford rabbit model is introduced to verify the effect of the proposed approach. Experimental results show that the proposed algorithm can effectively reflect the details of the point cloud despite a simplification proportion of up to 90%. Compared to traditional curvature simplification algorithms, the proposed method has the lowest deviation and highest accuracy at the same simplicity level, as numerous feature points are preserved, which facilitates the point cloud processing.
Small molecule donors with different conjugated π linking bridges: Synthesis and photovoltaic properties
Authors: Dong Xiyue , Hu Dingqin , Chen Pengyu , Dai Xuexin , Hu Chao , Xiao Zeyun , Lu Shirong 
Published: December 2020

Abstract
Three small molecule (SM) donors, namely B-T-CN, B-TT-CN and B-DTT-CN, with different π conjugated bridges were synthesized in this research. Interestingly, with the conjugated fused rings of the π linking bridge increasing, the SM HOMO levels exhibit a decline tendency with –5.27 eV for B-T-CN, –5.31 eV for B-TT-CN and –5.40 eV for B-DTT-CN. After blending the SM donors with the fullerene acceptor PC71BM, the all SM organic solar cells (OSCs) achieved high V
ocs of 0.90 to 0.96 V. However, the phase separation morphology and molecule stacking are also unexpectedly changed together with the enhancement of conjugated degree of π bridges, resulting in a lower power conversion efficiency (PCE) for the B-DTT-CN:PC71BM device. Our results demonstrate and provide a useful way to enhance OSC V
oc and the morphology needs to be further optimized.
Comprehensive study of crystalline AlN/sapphire templates after high-temperature annealing with various sputtering conditions
Authors: Gu Wen , Liu Zhibin , Guo Yanan , Wang Xiaodong , Jia Xiaolong , Liu Xingfang , Zeng Yiping , Wang Junxi , Li Jinmin , Yan Jianchang 
Published: December 2020

Abstract
High-quality AlN/sapphire templates were fabricated by the combination of sputtering and high-temperature (HT) annealing. The influence of sputtering parameters including nitrogen flux, radio frequency power, and substrate temperature on the crystalline quality and surface morphology of annealed AlN films were investigated. With lower substrate temperature, lower power, and lower N2 flux, the full width at half maximum of the X-ray rocking curve for AlN (0002) and (10

2) were improved to 97.2 and 259.2 arcsec after high-temperature annealing. This happens because the increased vacancy concentration of sputtered AlN films can facilitate the annihilation of dislocations by increasing the recovery rate during HT annealing. Step and step-bunching morphologies were clearly observed with optimized sputtering conditions.
Extreme sea level variability dominates coastal flood risk changes at decadal time scales
Authors: Rashid M M , Wahl T , Chambers D P 
Published: December 2020

Abstract
Coastal flood risk assessments typically ignore interannual to multidecadal variability stemming from mean sea level, storm surges, and long period tides (i.e. 4.4 year perigean and 18.6 year nodal cycles), although combined these can lead to significant variations in extreme sea levels (ESL). Here, we examine the effects of ESL variability on the amplification of flood frequencies and risks for 17 major U.S. coastal cities. We also quantify the relative importance of ESL variability compared to long-term relative sea level rise (RSLR). Results show that, depending on the region, observed ESL variability can lead to amplification factors of up to 79, indicating that the 100 year return period event can become a 1.26 year event during certain time periods when ESL variability peaks high. Additionally, depending on the RSLR scenario considered, the observed range of ESL variability is equivalent to the RSLR projected to occur over the next few years in some locations and several decades (up to 2100) in others. These ESL fluctuations also modulate flood risk estimates, with the aggregated 100 year flood losses for the 17 major U.S. coastal cities changing by up to US$ 141 979 million (or 28%). This study demonstrates the importance of including ESL variability in regional coastal flood risk assessments; it highlights the importance of being aware and vigilant of these variations when observed and projected ESL situations are quantified assuming that certain sea level components are stationary.
Majority of German citizens, US citizens and climate scientists support policy advocacy by climate researchers and expect greater political engagement
Authors: Cologna Viktoria , Knutti Reto , Oreskes Naomi , Siegrist Michael 
Published: December 2020

Abstract
Scientists’ role in outreach and advocacy has been debated extensively, but empirical evidence on its perceived legitimacy is scarce. We contacted scientists researching climate change to investigate scientists’ engagement levels, as well as expectations regarding political and public engagement. We then compared how scientists (N = 1107) and German and US citizens (N = 884) view scientists’ engagement and how scientists’ advocacy affects their credibility. We find that perceptions differ across countries, with scientists perceiving more strongly than the public that scientists should politically and publicly engage. However, the public agrees that scientists should engage, and that they should increase these efforts. The majority of citizens agrees that scientists should advocate for climate-related policies and work closely with policymakers but refrain from endorsing climate protests. Further, openly supporting climate policies does not adversely affect scientists’ perceived trustworthiness or honesty, while it negatively affects perceptions of scientists’ objectivity. Our study provides empirical evidence that can help climate change researchers to better understand the public’s demand for, and perceived legitimacy of, different engagement activities.