bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolite plasticity drives carbon-nitrogen resource budgeting to enable division of labor in a clonal community
Authors: Varahan Sriram , Sinha Vaibhhav , Walvekar Adhish , Krishna Sandeep , Laxman Sunil 
Published: April 2020

AbstractPreviously, we discovered that in glucose-limited yeast colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic and glycolytic metabolic states. Here, threshold amounts of trehalose - a limiting, produced resource, controls the emergence and self-organization of the cells exhibiting the glycolytic state, by acting as a carbon source to fuel these metabolic demands (Varahan et al., 2019). We now discover that the plasticity of use of a non-limiting resource, aspartate, controls both resource production and the emergence of heterogeneous cell states, based on differential cellular metabolic budgeting. In gluconeogenic cells, aspartate provides carbon for trehalose production, while in glycolytic cells using trehalose for carbon, aspartate supplies nitrogen to drive nucleotide synthesis. This metabolic plasticity of aspartate enables carbon-nitrogen budgeting, thereby driving the biochemical self-organization of distinct cell states. Through this organization, cells in each state exhibit true division of labor, providing bet-hedging and growth/survival advantages for the whole community.
Transcriptome analysis of the zebrafishatoh7−/−mutant,lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases
Authors: Covello Giuseppina , Rossello Fernando J. , Filosi Michele , Gajardo Felipe , Duchemin Anne-Laure , Tremonti Beatrice F. , Eichenlaub Michael , Polo Jose M. , Powell David , Ngai John , Allende Miguel L. , Domenici Enrico , Ramialison Mirana , Poggi Lucia 
Published: April 2020

ABSTRACTExpression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. A number of studies have emerged establishingATOH7as a retinal disease gene. Remarkably, such studies uncoveredATOH7variants associated with global eye defects including optic nerve hypoplasia, microphthalmia, retinal vascular disorders and glaucoma. The complex genetic networks and cellular decisions arising downstream ofatoh7expression, and how their dysregulation cause development of such disease traits remains unknown. To begin to understand such Atoh7-dependent eventsin vivowe performed transcriptome analysis of wild type andatoh7mutant (lakritz) zebrafish embryos at the onset of retinal ganglion cell differentiation. We investigatedin silicointerplays ofatoh7and other disease-related genes and pathways. By network reconstruction analysis of differentially expressed genes we identified gene clusters enriched in retinal development, cell cycle, chromatin remodelling, stress response and Wnt pathways. By weighted gene coexpression network we identified coexpression modules affected by the mutation and enriched in retina development genes tightly connected toatoh7. We established the groundwork whereby Atoh7-linked cellular and molecular processes can be investigated in the dynamic multi-tissue environment of the developing normal and diseased vertebrate eye.
Triclosan depletes the membrane potential inPseudomonas aeruginosabiofilms inhibiting aminoglycoside induced adaptive resistance
Authors: Maiden Michael M. , Waters Christopher M. 
Published: April 2020

AbstractBiofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections. Exposure to aminoglycosides induces adaptive resistance inPseudomonas aeruginosabiofilms. Adaptive resistance is primarily the result of active antibiotic export by RND-type efflux pumps, which use the proton motive force as an energy source. We show that the protonophore uncoupler triclosan depletes the membrane potential of biofilm growingP. aeruginosa, leading to decreased activity of RND-type efflux pumps. This disruption results in increased intracellular accumulation of tobramycin and enhanced antimicrobial activityin vitro. In addition, we show that triclosan enhances tobramycin effectivenessin vivousing a mouse wound model. Combining triclosan with tobramycin is a new anti-biofilm strategy that targets bacterial energetics, increasing the susceptibility ofP. aeruginosabiofilms to aminoglycosides.Author summaryAdaptive resistance is a phenotypic response that allowsP. aeruginosato transiently survive aminoglycosides such as tobramycin. To date, few compounds have been identified that target adaptive resistance. Here, we show the protonophore uncoupler triclosan disrupts the membrane potential ofP. aeruginosa. The depletion of the membrane potential reduces efflux pump activity, which is essential for adaptive resistance, leading to increased tobramycin accumulation and a shorter onset of action. Our results demonstrate that in addition to its canonical mechanism inhibiting membrane biosynthesis, triclosan can exert antibacterial properties by functioning as a protonophore that targetsP. aeruginosaenergetics.
Effects of spectral light quality on the growth, productivity, and elemental ratios in differently pigmented marine phytoplankton species
Authors: Bercel T. L. , Kranz S. A. 
Published: April 2020

AbstractEffects of light quality on the growth, productivity, and cellular composition of three uniquely pigmented marine phytoplankton species were characterized. To accomplish this, cultures ofProchlorococcus marinus, Synechococcus sp., andThalassiosira weissflogiiwere grown under three commercially available LEDs as well as a fluorescent growth light. Despite having equal photosynthetically active radiation, light quality and thus photosynthetically usable radiation differed between the treatments. Growth was unaffected in all species tested, yet primary productivity was affected inP. marinusandSynechococcus sp.All species regulated cellular carbon and nitrogen quotas as a direct response to light spectra, while cellular chlorophyllawas regulated inSynechococcus sp.andT. weissflogiionly. Analysis of pigment ratios revealed minor acclimations in some of the cultures and photophysiological analysis indicated changes in the photoacclimation state between different light environments. These results show that while the species used in our experiment are able to maintain growth when exposed to lights of varying quality, underlying cellular metabolism and biochemistry can be affected. The data presented here highlight the importance of carefully choosing a lighting environment with a defined spectral quality when designing laboratory-based experiments or setting up bioreactors for biomass generation.HighlightWith light emitting diode-based growth lights becoming available to researchers, it is important to consider the spectral quality of light when designing experiments to understand responses of phytoplankton to environmental conditions.
Robust data-driven auditory profiling towards precision audiology
Authors: Sanchez-Lopez Raul , Fereczkowski Michal , Neher Tobias , Santurette Sébastien , Dau Torsten 
Published: April 2020

AbstractThe sources and consequences of a sensorineural hearing loss are diverse. While several approaches have aimed at disentangling the physiological and perceptual consequences of different etiologies, hearing deficit characterization and rehabilitation have been dominated by the results from pure-tone audiometry. Here, we present a novel approach based on data-driven profiling of perceptual auditory deficits that attempts to represent auditory phenomena that are usually hidden by, or entangled with, audibility loss. We hypothesize that the hearing deficits of a given listener, both at hearing threshold and at supra-threshold sound levels, result from two independent types of “auditory distortions”. In this two-dimensional space, four distinct “auditory profiles” can be identified. To test this hypothesis we gathered a dataset consisting of a heterogeneous group of listeners that were evaluated using measures of speech intelligibility, loudness perception, binaural processing abilities and spectro-temporal resolution. The subsequent analysis revealed that distortion type-I was associated with elevated hearing thresholds at high frequencies and reduced temporal masking release and was significantly correlated with elevated speech reception thresholds in noise. Distortion type-II was associated with low-frequency hearing loss and abnormally steep loudness functions. The auditory profiles represent four robust subpopulations of hearing-impaired listeners that exhibit different degrees of perceptual distortions. The four auditory profiles may provide a valuable basis for improved hearing rehabilitation, e.g. through profile-based hearing-aid fitting
Temporal Association Between Particulate Matter Pollution and Case Fatality Rate of COVID-19 in Wuhan, China
Authors: Yao Ye , Pan Jinhua , Liu Zhixi , Meng Xia , Wang Weidong , Kan Haidong , Wang Weibing 
Published: April 2020

AbstractThe Coronavirus (COVID-19) epidemic, which was first reported in December 2019 in Wuhan, China, has caused 3,314 death as of March 31, 2020 in China. This study aimed to investigate the temporal association between case fatality rate (CFR) of COVID-19 and particulate matter (PM) in Wuhan. We conducted a time series analysis to explore the temporal day-by-day associations. We found COVID-19 held higher case fatality rate with increasing concentrations of PM2.5 and PM10 in temporal scale, which may affect the process of patients developed from mild to severe and finally influence the prognosis of COVID-19 patients.
Environmental palaeogenomic reconstruction of an Ice Age algal population
Authors: Lammers Youri , Heintzman Peter D. , Alsos Inger Greve 
Published: April 2020

AbstractPalaeogenomics has greatly increased our knowledge of past evolutionary and ecological change, but has been restricted to the study of species that preserve as fossils. Here we show the potential of shotgun metagenomics to reveal population genomic information for a taxon that does not preserve in the body fossil record, the algaeNannochloropsis. We shotgun sequenced two lake sediment samples dated to the Last Glacial Maximum and identifiedN. limneticaas the dominant taxon. We then reconstructed full chloroplast and mitochondrial genomes to explore within-lake population genomic variation. This revealed at least two major haplogroups for each organellar genome, which could be assigned to known varieties ofN. limnetica. The approach presented here demonstrates the utility of lake sedimentary ancient DNA (sedaDNA) for population genomic analysis, thereby opening the door to environmental palaeogenomics, which will unlock the full potential ofsedaDNA.
Is corporate governance maturity measurable?
Authors: Rehman Ali , Hashim Fathyah 
Published: April 2020

Purpose
This study aims to intend toward the measurement of corporate governance to identify its maturity levels within Omani public listed companies and also propose to identify whether corporate governance maturity (CGM) levels vary significantly between sectors or not. CGM is an innovation in the field of corporate governance, which assists organizations in achieving their objectives and satisfying shareholders.

Design/methodology/approach
This study used descriptive cross-sectional survey design. Data are collected by the internet-based tool and analyzed via SPSS.

Findings
This study found that corporate governance is measurable and can be measured to the levels of maturity. Moreover, this study identified that CGM does not differ among different sectors. From a total of 107 organizations, none of the organizations falls under the forming level and mature level. However, majority of organizations falls under normalized level followed by developing and established levels of maturity.

Practical implications
This study integrates significant empirical research and literature to broaden the potentials of CGM. This study provides a framework along with a calculation tool, which can be used by organizations, regulators and policymakers.

Originality/value
To the best of the authors’ knowledge, the maturity levels of Omani organizations are never being measured before. Moreover, past studies demonstrate single constituent relationship with CGM and not all four. Therefore, this study is distinctive from others by testing all four major components or constituents toward CGM.
Consumers’ intentions to use online food delivery systems in the USA
Authors: Gunden Nefike , Morosan Cristian , DeFranco Agnes 
Published: April 2020

Purpose
The recent development of online food delivery systems (OFDS) consolidated the restaurant industry’s representation in the electronic distribution landscape. The purpose of this study is to examine consumers’ intentions to use OFDS.

Design/methodology/approach
A comprehensive structural model was developed based on UTAUT2 and extended the model with three additional constructs: impulse buying tendency, congruity with self-image and mindfulness. Data were collected from 605 US respondents. Confirmatory factor analysis and structural equation modeling were used to test the model.

Findings
Performance expectancy was the strongest predictor of intentions to use OFDS, followed by congruity with self-image. Low-magnitude predictors included habit and mindfulness, while impulse buying tendency had a negative impact on intentions to use OFDS.

Research limitations/implications
The study validates a comprehensive yet parsimonious conceptual model that explains consumers’ intentions to use OFDS. The model brings together constructs that capture the essence of the online food ordering tasks and the consumers’ cognitive processes that inform such tasks.

Practical implications
This study offers substantial practical implications for two types of practitioners: OFDS developers and restaurants and provides a mapping of the factors influencing consumers’ intentions to use OFDS.

Originality/value
This study provides a first theoretical perspective on consumers’ intentions to use OFDS, which have not been studied so far. Studying such intentions provides insight into consumers’ adoption behaviors, which are critical to the success of OFDS.
Wine-related lifestyle segmentation in the context of urban Indian consumers
Authors: Sharma Poonam , Singh Sonali , Misra Richa 
Published: April 2020

Purpose
The purpose of this study is to understand consumers in the emerging wine market of India to ensure the best services. To this end, factors were identified to describe Indian wine consumer behavior and further segments for consumers were created based on the factors identified.

Design/methodology/approach
The research design is descriptive in nature and based on primary data. Data was collected by a structured questionnaire from 232 respondents in five major cities of India (Mumbai, Delhi NCR, Bangalore, Pune and Hyderabad). The scale was mainly adopted from wine-related lifestyle approaches.

Findings
The principal component factor analysis resulted in six factors, namely, drinking ritual, consumption reason (social), consumption reason (mood, enjoyment and relaxation), consumption practice, consumption planning and quality. Cluster analysis resulted in a three-cluster solution. These clusters were named as cautious social drinker, loner regular drinker and highly engaged drinker based on the attributes possessed.

Originality/value
The segmentation of urban Indian wine consumers will be helpful for marketers to identity and describe the differences in attributes and behaviors, to create customized promotions to match the needs.
Study on oil film pressure distribution and load capacity of textured rolling bearings
Authors: Han Ka , Li Junning , Wang Qian , Chen Wuge , Xue Jiafan 
Published: April 2020

Purpose
The purpose of this study is to reveal the tribological performance of the textured rolling bearing.

Design/methodology/approach
In the present study, the oil film pressure distribution and load capacity analysis method are established, which integrate the micro-texture model and Hydrodynamic lubrication (HL) methods. The tribological performances of the textured rolling bearing under the various working condition, texture dimension and texture type are investigated systematically.

Findings
The results show that the oil film load capacity increases with the increase in the texture size. As the texture depth increases, the oil film load capacity increases first and then decreases, and then the load capacity is the largest at the texture depth range of 3 to 5 µm. In addition, the oil film load capacity of the matching pairs, such as Si4N3-Si4N3, GCr15- Si4N3 and GCr15-GCr15 are compared; the results show that the cases of using ceramic material can improve oil film load capacity of textured rolling bearing.

Originality/value
The current manuscript can be useful for supporting the reliability and life research of textured rolling bearing.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-02-2020-0055
Inventory management of perishable health products: a decision framework with non-financial measures
Authors: Duong Linh Nguyen Khanh , Wood Lincoln C. , Wang William Yu Chung 
Published: April 2020

PurposeThis research proposes a decision framework for using non-financial measures to define a replenishment policy for perishable health products. These products are perishable and substitutable by nature and create complexities for managing inventory. Instead of a financial measure, numerous measures should be considered and balanced to meet business objectives and enhance inventory management.Design/methodology/approachThis research applies a multi-methodological approach and develops a framework that integrates discrete event simulation (DES), analytic hierarchy process (AHP) and data envelopment analysis (DEA) techniques to define the most favourable replenishment policy using non-financial measures.FindingsThe integration framework performs well as illustrated in the numerical example; outcomes from the framework are comparable to those generated using a traditional, financial measures-based, approach. This research demonstrates that it is feasible to adopt non-financial performance measures to define a replenishment policy and evaluate performance.Originality/valueThe framework, thus, prioritises non-financial measures and addresses issues of lacking information sharing and employee involvement to enhance hospitals' performance while minimising costs. The non-financial measures improve cross-functional communication while supporting simpler transformations from high-level strategies to daily operational targets.
The use of social media as a legitimation tool for sustainability reporting
Authors: Lodhia Sumit , Kaur Amanpreet , Stone Gerard 
Published: April 2020

PurposeThis paper aims to examine the use of social media for sustainability reporting by the largest Australia companies as a means of seeking legitimacy from stakeholders.Design/methodology/approachQualitative content analysis was applied to examine social and environmental disclosures posted by Australian companies on three social media platforms – Facebook, Twitter and LinkedIn, and to observe stakeholder interaction in relation to the social and environmental postings.FindingsThe findings of this study indicate a limited use of social media by the top 50 Australian Stock Exchange (ASX) listed companies for sustainability reporting as only 46 per cent of the companies used Facebook, Twitter and/or LinkedIn. Nevertheless, those companies which actively used social media were able to seek legitimacy through information disclosure and dialogue with stakeholders. Social issues such as community support, employees, gender equality and diversity dominated the three social media platforms when compared to environmental issues and all disclosures had a positive tone. These disclosures in turn framed the dialogue with stakeholders, leading to use of social media platforms that companies preferred and enabling a close control over online discussions.Research limitations/implicationsThis study highlights that social media sustainability communication focuses on symbolic legitimacy strategies, leading to companies managing the impressions of their stakeholders and controlling the dialogue with them.Practical implicationsThis study provides an understanding of the actual practice of social media sustainability communication and has implications for both organisations and their stakeholders.Originality/valueThis study provides in-depth insights into the use of social media to transform sustainability reporting, an issue that has limited coverage in prior literature and extends the application of legitimacy theory to social media communication.
The predictability of the metabolic syndrome by adipokines
Authors: Aliasghari Fereshteh , Aliasgharzadeh Soghra , Faghfouri Amir Hossein , Mahdavi Reza , Lotfi Yagin Neda 
Published: April 2020

PurposeObesity can cause impairment in adipose tissue-derived hormones levels, which, in turn, might lead to metabolic syndrome occurrence. This study aims to assess the relationship between the levels of adiponectin, resistin, retinol-binding protein 4 (RBP4) and insulin with metabolic syndrome (MetS) indices. Also, optimal cutoff points of the adipokines and insulin for MetS prediction were determined.Design/methodology/approachIn this study, 180 women (90 women with MetS and 90 women without MetS) were studied. The National Cholesterol Education Program Adult Treatment Panel III criteria were used for MetS diagnosis. Anthropometric and biochemical indices were measured. Data were analyzed using SPSS software version 21.FindingsSerum adiponectin correlated negatively with age, BMI, waist circumference (WC), triglyceride (TG), total cholesterol, SBP, DBP, FBS and positively correlated with high-density lipoprotein-cholesterol. Both resistin and RBP4 levels correlated positively with BMI, WC, TG, SBP, DBP and FBS. Also, serum insulin correlated positively with BMI, WC, SBP and DBP. All the studied adipokines and insulin showed significant areas under the receiver operating characteristics curve. The largest area under the curve was observed for adiponectin (0.93, 95 per cent CI = 0.89-0.97,p< 0.001) with the optimal cut-off point of 11.94 µg/L. Also, the upper level of adiponectin was associated with 70 per cent lower prevalence odds of metabolic syndrome after adjusting for confounders.Originality/valueThe authors determined the optimal cutoff points of the adipokines and insulin for MetS prediction and calculated the diagnostic odds ratio for various cutoff values. Adiponectin could be used as a biomarker in MetS regarding its largest AUC.