bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved electronics for 3He based neutron counters
Authors: Boogers Eric , Borella Alessandro , Rossa Riccardo 
Published: January 2020

Several non-destructive assays techniques have been developed for the measurement of fissile materials in the fields of dismantling, decommissioning, nuclear security, and nuclear safeguards. Among these techniques, neutron coincidence counting is based on the detection of time-correlated neutrons from induced and spontaneous fissions. 3He Tubes have been the primary choice for neutron coincidence counting due to their high detection efficiency, rather low sensitivity to gamma-rays and proven field reliability. This paper covers the implementation of a new electronic setup to a Canberra WM3400 neutron coincidence counter.
First we describe the properties of the used detectors, with focus on the characteristics of the default electronics and highlight its limitations such as the high input capacitance, short shaping time and the necessity for selected tubes. We then propose the new electronic setup to overcome these limitations. This setup includes a dedicated preamp for every tube , the possibility to adjust for gain differences between the tubes and a better optimised shaping time for 3He detectors.
We carried out measurements with the two electronic systems to compare their performances in terms of gamma-ray sensitivity, efficiency and die-away time. The gamma ray sensitivity was measured with calibrated 137Cs and a 60Co sources at the Laboratory for Nuclear Calibration of the Belgian Nuclear Research Centre with dose rates between 10 μSv/h and 50 mSv/h. Measurements with a 252Cf source were used to determine the die-away time of the system and the total measurement efficiency for the considered geometry.
The measurements showed that, with the default electronics, neutron count-rates are already affected by gamma radiation at a dose rate of 10÷30 μSv/h. On the other hand the neutron coincidence counter equipped with the new electronics proved to be insensitive to gamma-radiation up to a dose rate of at least 20 mSv/h. The high-voltage set with the new electronics is lower than in the case of the default electronics and is within the range recommended by the tubes manufacturer. The die-away time was not affected by the used electronics. A reduction of about 20% in the neutron detection efficiency due to the used discriminator threshold was observed.
Active Neutron Monitoring of Nuclear Fuel Cycle Fissile Materials
Authors: Batyaev V.F. , Karetnikov M.D. , Sklyarov S.V. 
Published: January 2020

A decommissioning of nuclear fuel cycle facilities is inseparable from the problems of radioactive waste disposal. One of these problems is the categorization of a waste according to the content of beta- and alpha-emitters. Beta-emitters can be identified by existing technologies; however, the trouble arises when detecting alpha-emitting elements, primarily the long-lived members of the actinium chain with the specific activity of kBq/kg when they are spread inside a structural material. The report considers an application of an active neutron method-a differential die-away technology for reliable control of small quantities of FM.
The essence of this method consists in sounding the interrogated item by pulsed thermal neutrons and recording the induced fission neutrons. The ratio of the number of fission neutrons to the number of source neutrons gives the normalized number of fission neutrons that is linked to the FM mass in the interrogated object. The work presents the scheme and principle of operation of an experimental device, as well as the results of measurement of concrete structures that contain internal traces of fissile materials. Analysis of the results shows that the proposed method allows the detection of ~ 6 mg of fissile material per kg of concrete with possible localization (cartogram) of the contaminated area.
Image texture analysis and colorimetry for the classification of uranium ore concentrate powders
Authors: Marchetti Mara , Mayer Klaus , Wallenius Maria , Bulgheroni Antonio , Wiss Thierry , Lützenkirchen Klaus , Fongaro Lorenzo 
Published: January 2020

In the context of nuclear security, uranium ore concentrates (UOCs) play an important role: they are traded in large quantities and this makes their use “out of regulatory control” a possible scenario.
Once an incident of illicit trafficking o f n uclear m aterial is detected, an understanding of its origin and production process is required; this implies the necessity to use analytical techniques able to measure characteristic parameters (e.g. physical, chemical, isotopic characteristics of the nuclear materials) which are referred to, in the field o f t he n uclear f orensics, a s signatures.
The present study investigates the potential of image texture analysis (i.e. the angle measure technique), combined with the spectrophotometric determination of colours for the evaluation of the origin of several UOCs. The use of different multivariate statistical techniques allows the categorization of about 80 different samples into a few groups of UOCs powders, which makes this approach a promising method complementing the already established methods in nuclear forensics.
An In Vitro Comparative Evaluation of the Effects of Different Bleaching Agents on Marginal Integrity of Two Different Restorative Resin Materials: An Analysis by Confocal Laser Microscopy
Authors: Goyal Nitesh , Kumar Yogesh , Jindal Neetu , Aggarwal Renu 
Published: January 2020

Abstract
Introduction In our society, with the advances in cosmetic consciousness, well-aligned, properly contoured, white and clean teeth are a symbol of health and standard of beauty. Thus, tooth bleaching has become popular cosmetic therapy among patients and dentists. Microleakage is a major challenge to the success rate for all type of restorations.
Materials and Methods Eighty maxillary human molars were collected and evaluated and Class V cavities 5×3×2 mm size were prepared with straight carbide bur (SS White) on the buccal and palatal surfaces at the cementoenamel junction of all the samples, so that the upper margin would be in enamel and lower margins on root surface. In total, 160 class V cavities were prepared on maxillary molars. Then samples were randomly divided into 3 groups (microfilled and nanohybrid composite resins and control group) and 3 subgroups (Pola Office, Whiteness HP Blue, Whiteness Perfect) according to the type of composite resins and bleaching agents used. After application of bleaching agents, all samples were immersed in a contrast solution of rhodamine B fluorescent dye for 24 hours. Then using a diamond disc samples were sectioned buccolingually through the center of the restorations and sectioned teeth were evaluated for marginal microleakage under confocal laser scanning microscope to check the extent of dye penetration.
Results When all composite resin groups were compared with all the bleaching agents, at occlusal and gingival levels, lowest marginal leakage scores were obtained with the microfilled composite resin bleached with Whiteness HP blue, and in nanohybrid composite lowest microleakage score were obtained with Pola office bleach at both levels.
Submucosal Myoma Treatment for Women Who Wish to have Children in the Future Nodule Dissection Centripetal Cutting Method of TCR (Transcervical Resection)
Authors: Inoue Shigeo 
Published: January 2020

AbstractDue to the recent trend to marry later, patients with uterine myoma, and who wish to preserve their uterus have increased, are leading to greater demand for minimally invasive myomectomies. For intramural myomas and submucosal myomas, which are located near the uterine cavity, which are high risk for sterility or infertility, incision of the myometrium, and suture to the uterine cavity during laparoscopic myomectomy is required, and Caesarean section is frequently selected as the child delivery method. Hysteroscopic myomectomy is advantageous for persons wishing for pregnancy. The abdominal wall is not damaged, and there is less pain and a shorter hospital stay. Hysteroscopic myomectomy does not cause postoperative intraperitoneal adhesion, contraceptive period is shorter, and vaginal delivery is also possible. Since expensive disposal surgical instrument, surgery assistants are not needed, it also contributes to medical economy, and its widespread is desired. On the other hand, learning the technique is difficult, since unique complications may occur and only an endoscope in the specific field of vision, the uterine cavity is used for this procedure. If only cases with small submucosal myoma are indicated for hysteroscopic myomectomy, technical improvement and wider adoption will not occur. However, if the indication can be correctly recognized and a safe and accurate technique be acquired, adoption of hysteroscopic myomectomy could actually be widened. It is an excellent technique which can become mainstream for fibroid treatment.
Febrile Status Epilepticus
Authors: Molinero Isaac , Shinnar Shlomo 
Published: January 2020

AbstractFebrile status epilepticus (FSE) is defined as a febrile seizure lasting 30 minutes or more and is considered the extreme end of the complex febrile seizure spectrum. It remains unclear why some children are predisposed to the development of FSE compared with others. FSE is considered as medical emergency and as such, early treatment is crucial. The consequences of FSE have been a topic of interest for many years, specially its association with temporal lobe epilepsy and hippocampal sclerosis. In this article, we review the epidemiology, risk factors, pathophysiology, treatment, and prognosis including findings from the “Consequences of Prolonged Febrile Seizures in Childhood” (FEBSTAT) study.
Comparison of Bispectral Index-Guided Administration of Desflurane and Propofol for Endoscopic Transnasal Transsphenoidal Resection of Pituitary Tumors
Authors: Bharadwaj Devika , Mahajan Charu , Aggarwal Richa , Prabhakar Hemanshu , Chaturvedi Arvind 
Published: January 2020

Abstract
Background Use of short-acting anesthetic agents such as propofol and desflurane allows rapid awakening and prompt neurological assessment of patients undergoing endoscopic transnasal transsphenoidal resection of pituitary tumors. However, there are no studies comparing the effect of these two agents in these patients. We performed this study to compare the intraoperative hemodynamics and postoperative recovery characteristics of patients undergoing endoscopic transnasal transsphenoidal (TNTS) pituitary tumor surgery using bispectral index (BIS)-guided administration of desflurane and propofol.
Materials and Methods In this prospective, randomized trial, 60 patients undergoing endoscopic TNTS pituitary surgery were randomized to receive BIS-guided administration of either propofol (Group P) or desflurane (Group D) for the maintenance of anesthesia. Heart rate (HR), mean arterial pressure (MAP), intraoperative complications, time to emergence, extubation, cognition, and modified Aldrete score were evaluated. Statistical analysis was performed using STATA 12.0. Categorical and continuous variables were compared between the groups using Fisher’s exact test and t-test, respectively. Emergence from anesthesia and hemodynamics at various stages of surgery was compared between the groups using Wilcoxon rank sum test. The p-value < 0.05 was considered statistically significant.
Results The HR was significantly higher at all stages of surgery in group P (p = 0.01). MAP was comparable between the groups at various time points (p > 0.05). Both emergence time (8.5 vs. 15 minutes; p < 0.00) and extubation time (10 vs. 17.5 minutes; p < 0.00) were significantly shorter in Group D compared with Group P. Modified Aldrete score at 5 and 10 minutes after extubation was higher with desflurane than propofol, but early cognition was comparable between the two groups.
Conclusion The hemodynamics and early cognition score were comparable in patients receiving propofol or desflurane. Desflurane provides rapid emergence and recovery when compared with propofol.
Embryological basis of malformed female genital tract and various classifications
Authors: Niranjan Richa , Singh A K , Yadav Anjoo 
Published: January 2020

AbstractDevelopmental anomalies of the Mullerian duct system represent some of the most fascinating disorders that obstetricians and gynaecologists encounter. The uterus is formed during embryogenesis by the fusion of the two paramesonephric ducts (Mullerian ducts). This process usually fuses the two Mullerian ducts into a single uterine body, but fails to take place in the affected women who maintain their double Mullerian systems. A bicornuate uterus is a type of a uterine malformation where upper part of uterus forms two horns. The fusion process of upper part of Mullerian duct is altered. As a result, cranial part of the uterus becomes bifurcated. As Mullerian duct anomalies are of anatomic interest, this article discusses epidemiology, embryological development, genetics of development and malformation and lastly various classifications based on Mullerian duct development. Pregnancy in bicornuate uterus is usually of high risk with reproductive outcomes like recurrent abortions, preterm delivery or malpresentation. Classifying Mullerian duct anomalies bears merit because it correlates anatomic anomalies with arrests in morphogenesis. Establishing an accurate diagnosis is essential for planning treatment and management strategies.
Morphology and morphometry of infra orbital foramen in South Indian adult dry skulls
Authors: K. Vishal , V. Vinay K , P. Johncy I 
Published: January 2020

Abstract
Background: The infra orbital foramen (IOF) situated below infra-orbital margin (IOM) transmits infra­orbital nerve and infra- orbital vessels. The knowledge of the dimension, shape and direction of the IOF has important implications in various surgical and anaesthetic procedures. This will avoid iatrogenic injury to neurovascular bundle emerging from the IOF. Material and methods: Sixty adult dry skulls of unknown sex from the Department of Anatomy and Department of Forensic Medicine were used. IOF on both sides of skulls were assessed for the shape and direction by inspection. The vertical and horizontal diameter of the IOF was measured using a digital Vernier caliper to the nearest millimeters and the results were statistically analyzed. Results: The shape of the IOF was vertically oval in majority of the skulls (37.5%) and was semi lunar shaped in 10.83% of the skull. The IOF was directed infero­medially in about 52.5% of the cases and was directed medially in 6.67% of the cases. The mean transverse diameter was 2.96mm and the mean vertical diameter was 3.7mm. All the above results were compared with studies of previous workers. Conclusion: The present study confirms that there is racial as well as regional variation in the shape and dimensions of IOF, thus emphasizing the need to have morphometric data for South Indian population.
Retinal inputs signal astrocytes to recruit interneurons into visual thalamus
Authors: Su Jianmin , Charalambakis Naomi E. , Sabbagh Ubadah , Somaiya Rachana D. , Monavarfeshani Aboozar , Guido William , Fox Michael A. 
Published: January 2020

Significance
Local inhibition, mediated by thalamic interneurons, contributes to the processing of visual information and is essential for vision. However, the mechanisms underlying the development of these interneurons remains unresolved. In this study, we sought to identify mechanisms that contribute to the long-distance migration of these interneurons into the visual thalamus. Our data show that innervation of the visual thalamus by retinal ganglion cells, the output neurons of the retina, is necessary for normal interneuron migration. Surprisingly, axons from these retinal ganglion cells appear to signal through astrocytes to contribute to thalamic interneuron migration. Astrocyte-derived cues may be a general mechanism for guiding interneuron migration throughout the brain.
Worldwide carrier frequency and genetic prevalence of autosomal recessive inherited retinal diseases
Authors: Hanany Mor , Rivolta Carlo , Sharon Dror 
Published: January 2020

Significance
By computing genotype data from six major world populations, we aimed at calculating how many individuals are affected with an autosomal recessive (AR) form of inherited retinal disease (IRD) or carry a mutation that can be transmitted to future generations. By analyzing variants in 187 IRD-associated genes, we detected 10,044 mutations and estimated that 2.7 billion individuals worldwide are carriers of an IRD disease-causing mutation, whereas 5.5 million are expected to be affected. This study will assist clinicians in their decision about the need to perform relevant genetic tests when diagnosing patients with IRDs. Similar studies can take advantage of our approach to calculate the expected number of affected or carrier individuals for any genetic disease with known molecular etiology.
Intestinal microbes influence development of thymic lymphocytes in early life
Authors: Ennamorati Maria , Vasudevan Chithirachelvi , Clerkin Kara , Halvorsen Stefan , Verma Smriti , Ibrahim Samira , Prosper Shaniah , Porter Caryn , Yeliseyev Vladimir , Kim Margot , Gardecki Joseph , Sassi Slim , Tearney Guillermo , Cherayil Bobby J. , Bry Lynn , Seed Brian , Jain Nitya 
Published: January 2020

Significance
The burgeoning intestinal microbiota pose a unique challenge to the developing immune system of the newborn. Extensive crosstalk between mucosal immune cells and microbes is necessary to establish healthy microbial communities and promote the development of productive mucosal immunity. However, it is yet unknown whether intestinal microbes also influence the development of lymphocytes themselves in the thymus. Here, we report that thymic distribution of transcription factor PLZF-expressing innate lymphocytes is regulated by intestinal microbes in early life. Migratory plasmacytoid dendritic cells are one conveyor of microbial information to developing thymic cells and perturbation of this entero-thymic communication in early life impacts disease susceptibility in adulthood. Our data highlight a novel regulation of thymic lymphocyte development by early-life microbiota.
A multicenter quality improvement initiative on the impact of pharmacists’ postdischarge follow-up to reduce medication-related acute care episodes
Authors: Noh Lydia , Heimerl Kristina , Shane Rita 
Published: January 2020

Abstract

Purpose
This multicenter quality improvement initiative aims to measure and quantify pharmacists’ impact on reducing medication-related acute care episodes (MACEs) for high-risk patients at an increased risk for readmission due to drug-related problems (DRPs).

Methods
This was a prospective, multicenter quality improvement initiative conducted at 9 academic medical centers. Each participant implemented a standardized methodology for evaluating MACE likelihood to demonstrate the impact of pharmacist postdischarge follow-up (PDFU). The primary outcome was MACEs prevented, and the secondary outcome was DRPs identified and resolved by pharmacists. During PDFU, pharmacists were responsible for identification and resolution of DRPs, and cases were reviewed by physicians to confirm whether potential MACEs were prevented.

Results
A total of 840 patients were contacted by 9 participating academic medical centers during a 6-week data collection period. Of these, 328 cases were identified as MACEs prevented during PDFU by pharmacists, and physician reviewers confirmed that pharmacist identification of DRPs during PDFU prevented 27.9% of readmissions. Pharmacist identified 959 DRPs, 2.8% (27) of which were identified as potentially life threatening. Potentially serious or significant DRPs made up 56.6% (543) of the DRPs, and 40.6% (389) were identified as having a low capacity for harm.

Conclusion
The results demonstrate that PDFU of high-risk patients reduces DRPs and prevents MACEs based on physician confirmation. Implementation of MACE methodology provides health-system pharmacy departments the ability to demonstrate pharmacists’ value in transitions of care and assist in expanding pharmacist services.
Dynamics of language reorganization after left temporo-parietal and frontal stroke
Authors: Stockert Anika , Wawrzyniak Max , Klingbeil Julian , Wrede Katrin , Kümmerer Dorothee , Hartwigsen Gesa , Kaller Christoph P , Weiller Cornelius , Saur Dorothee 
Published: January 2020

Abstract
The loss and recovery of language functions are still incompletely understood. This longitudinal functional MRI study investigated the neural mechanisms underlying language recovery in patients with post-stroke aphasia putting particular emphasis on the impact of lesion site. To identify patterns of language-related activation, an auditory functional MRI sentence comprehension paradigm was administered to patients with circumscribed lesions of either left frontal (n = 17) or temporo-parietal (n = 17) cortex. Patients were examined repeatedly during the acute (≤1 week, t1), subacute (1–2 weeks, t2) and chronic phase (&gt;6 months, t3) post-stroke; healthy age-matched control subjects (n = 17) were tested once. The separation into two patient groups with circumscribed lesions allowed for a direct comparison of the contributions of distinct lesion-dependent network components to language reorganization between both groups. We hypothesized that activation of left hemisphere spared and perilesional cortex as well as lesion-homologue cortex in the right hemisphere varies between patient groups and across time. In addition, we expected that domain-general networks serving cognitive control independently contribute to language recovery. First, we found a global network disturbance in the acute phase that is characterized by reduced functional MRI language activation including areas distant to the lesion (i.e. diaschisis) and subsequent subacute network reactivation (i.e. resolution of diaschisis). These phenomena were driven by temporo-parietal lesions. Second, we identified a lesion-independent sequential activation pattern with increased activity of perilesional cortex and bilateral domain-general networks in the subacute phase followed by reorganization of left temporal language areas in the chronic phase. Third, we observed involvement of lesion-homologue cortex only in patients with frontal but not temporo-parietal lesions. Fourth, irrespective of lesion location, language reorganization predominantly occurred in pre-existing networks showing comparable activation in healthy controls. Finally, we detected different relationships of performance and activation in language and domain-general networks demonstrating the functional relevance for language recovery. Our findings highlight that the dynamics of language reorganization clearly depend on lesion location and hence open new perspectives for neurobiologically motivated strategies of language rehabilitation, such as individually-tailored targeted application of neuro-stimulation.