bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular adaptation to calsequestrin 2 (CASQ2) point mutations leading to catecholaminergic polymorphic ventricular tachycardia (CPVT): comparative analysis of R33Q and D307H mutants
Authors: Valle Giorgia , Arad Michael , Volpe Pompeo 
Published: September 2020

AbstractHomozygous calsequestrin 2 (CASQ2) point mutations leads to catecholaminergic polymorphic ventricular tachycardia: a common pathogenetic feature appears to be the drastic reduction of mutant CASQ2 in spite of normal transcription. Comparative biochemical analysis of R33Q and D307H knock in mutant mice identifies different pathogenetic mechanisms for CASQ2 degradation and different molecular adaptive mechanisms. In particular, each CASQ2 point mutation evokes specific adaptive cellular and molecular processes in each of the four adaptive pathways investigated. Thus, similar clinical phenotypes and identical cellular mechanism for cardiac arrhythmia might imply different molecular adaptive mechanisms.
Discriminating larvae of two syntopic Cychramus species (Coleoptera, Nitidulidae) by means of bar-HRM analysis
Authors: Zangl Lukas , Oberreiter Hannes , Huss Herbert , Stabentheiner Edith , Sturmbauer Christian , Koblmüller Stephan 
Published: September 2020

AbstractMolecular genetic methods are increasingly used to supplement or substitute classical morphology-based species identification. Here, we employ a COI mini-barcode coupled high-resolution melting analysis to quickly, cost-efficiently and reliably determine larvae of two closely related Cychramus (Coleoptera, Nitidulidae) species. Euclidean distance comparison (p < 0.01) and a Welch t-test of the melting point temperatures (p < 0.01) provide highly significant statistical evidence for species specific differences in melting and fluorescence curves, thus allowing the assignment of larvae to either of the two species. This protocol serves as a fast, low-cost and low-tech method to discriminate between pairs or groups of closely related species and can be adapted and applied to various ecological research questions.
Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain
Authors: Pałasz Artur , Piwowarczyk-Nowak Aneta , Suszka-Świtek Aleksandra , Bogus Katarzyna , Filipczyk Łukasz , Vecchia Alessandra Della , Mordecka-Chamera Kinga , Menezes Itiana Castro , Worthington John J. , Krzystanek Marek , Wiaderkiewicz Ryszard 
Published: September 2020

AbstractNeuropeptides are important, multifunctional regulatory factors of the nervous system, being considered as a novel, atypical sites of antidepressants action. It has already been proven that some of them, such as selective serotonin reuptake inhibitors (SSRI), are able to affect peptidergic pathways in various brain regions. Despite these reports, there is so far no reports regarding the effect of treatment with SSRIs on brain proopiomelanocortin (POMC), kisspeptin, Kiss1R and MCHR1 gene expression. In the current study we examined POMC, kisspeptin, Kiss1R and MCHR1 mRNA expression in the selected brain structures (hypothalamus, hippocampus, amygdala, striatum, cerebellum and brainstem) of rats chronically treated with a 10 mg/kg dose of escitalopram using quantitative Real-Time PCR. Long-term treatment with escitalopram led to the upregulation of MCHR1 expression in the rat amygdala. Kisspeptin mRNA level was also increased in the amygdala, but Kiss1R mRNA expressions were elevated in the hippocampus, hypothalamus and cerebellum. POMC mRNA expressions were in turn decreased in the hippocampus, amygdala, cerebellum and brainstem. These results may support the hypothesis that these neuropeptides may be involved in the site-dependent actions of SSRI antidepressants. This is the first report of the effects of escitalopram on POMC, kisspeptin, Kiss1R and MCHR1 in animal brain. Our findings shed a new light on the pharmacology of SSRIs and may contribute to a better understanding of the alternative, neuropeptide-dependent modes of antidepressant action.
Spatiotemporal Expression and Bioinformatic Analyses of the HD-Zip Transcription Factor Family in Larix olgensis
Authors: An Peiqi , Cao Qing , Wang Chen , Wang Junhun , Zhang Hanguo , Zhang Lei 
Published: September 2020

AbstractLarix olgensis is one of the main coniferous tree species in northeastern China and has excellent timber properties and strong tolerance to stress. Thirteen HD-Zip family genes with a complete CDS region were identified on the basis of cambium transcriptome data from Larix olgensis. All 13 genes were analyzed via bioinformatics by their conserved domain protein sequence and amino acid composition, including their physicochemical properties and protein structure. The spatiotemporal expression and abiotic stress responses of these genes were analyzed by real-time quantitative PCR. The results showed that the 13 HD-Zip genes of Larix olgensis were expressed in the roots, stems, and leaves at different stages. The expression of three of these genes (LoHDZ2, LoHDZ11, LoHDZ13) was highest in nonlignified roots, indicating that they might be related to the secondary growth of Larix olgensis; in addition, three genes (LoHDZ5, LoHDZ9, LoHDZ10) were highly expressed in partially and completely lignified stems and leaves. These 13 genes were expressed specifically under drought stress. The expression of two of them (LoHDZ1, LoHDZ5) was obviously upregulated, and the expression of 6 genes (LoHDZ2, LoHDZ3, LoHDZ4, LoHDZ8, LoHDZ10, LoHDZ13) was significantly downregulated. The expression trends indicate that these genes could be involved in drought stress. The expression of all 13 genes was downregulated when the plants were treated with 0.2 M NaCl for 96 h, indicating that these genes are inhibited by salt stress. Overall, the results have significant implications for the study of the gene function of members of the LoHD-Zip transcription factor family.
Uniqueness of Dirichlet Forms Related to Infinite Systems of Interacting Brownian Motions
Authors: Kawamoto Yosuke , Osada Hirofumi , Tanemura Hideki 
Published: September 2020

AbstractThe Dirichlet forms related to various infinite systems of interacting Brownian motions are studied. For a given random point field μ, there exist two natural infinite-volume Dirichlet forms $ (\mathcal {E}^{\mathsf {upr}},\mathcal {D}^{\mathsf {upr}})$
(

E

u
p
r

,

D

u
p
r

)
and $(\mathcal {E}^{\mathsf {lwr}},\mathcal {D}^{\mathsf {lwr}})$
(

E

l
w
r

,

D

l
w
r

)
on L2(S,μ) describing interacting Brownian motions each with unlabeled equilibrium state μ. The former is a decreasing limit of a scheme of such finite-volume Dirichlet forms, and the latter is an increasing limit of another scheme of such finite-volume Dirichlet forms. Furthermore, the latter is an extension of the former. We present a sufficient condition such that these two Dirichlet forms are the same. In the first main theorem (Theorem 3.1) the Markovian semi-group given by $(\mathcal {E}^{\mathsf {lwr}},\mathcal {D}^{\mathsf {lwr}})$
(

E

l
w
r

,

D

l
w
r

)
is associated with a natural infinite-dimensional stochastic differential equation (ISDE). In the second main theorem (Theorem 3.2), we prove that these Dirichlet forms coincide with each other by using the uniqueness of weak solutions of ISDE. We apply Theorem 3.1 to stochastic dynamics arising from random matrix theory such as the sine, Bessel, and Ginibre interacting Brownian motions and interacting Brownian motions with Ruelle’s class interaction potentials, and Theorem 3.2 to the sine2 interacting Brownian motion and interacting Brownian motions with Ruelle’s class interaction potentials of $ {C_{0}^{3}} $

C

0

3

-class.
The great depression as a global currency crisis: An Argentine perspective
Authors: Zelmanovitz Leonidas , Newland Carlos , Rosiello Juan Carlos 
Published: September 2020

AbstractMany of the works that have tried to understand the proximate causes of the Great Depression have emphasized the consequences of maintaining the Gold Standard during the interwar period, as its innate inflexibility prevented the use of expansive monetary policies and generated recessionary deflationary processes. Another perspective, both complementary and different, is that offered by new works that consider the Great Depression as to some extent a consequence not so much of a Gold Standard per se, but of the return to redemability at an overvalued parity after the Great War. The novelty of this new approach is to stress the negative effect of maintaining an unbalanced price for the metal over time. The models that have analyzed the currency crises suffered in recent decades by many Latin American countries help to understand the path that led the world to the Great Depression, with the convertibility regime applied in Argentina between 1991 and 2001 being particularly relevant.
Between Education and Opinion-Making
Authors: Fooladi Erik C. 
Published: September 2020

AbstractThe fields of science education and science communication are said to have developed as disparate fields of research and practice, operating based on somewhat different logics and premises about their audiences. As the two fields share many of the same goals, arguments have been made for a rapprochement between the two. Drawing inspiration from a historical debate between the scholars John Dewey and Walter Lippmann, the present article is a case-oriented theoretical contribution applying models from science education and science communication in relation to a current socio-scientific issue (SSI), the COVID-19 pandemic. The main question of interest is how selected didactic (didaktik) models from science education and science communication can contribute to shed light on the present situation of an ongoing pandemic specifically and socio-scientific issues in general. Three models are synthesised to give a new composite model that may help communicators and educators understand, discuss, and analyse complex socio-scientific issues. The model is subsequently applied on the apparently contradictory issue of Norwegian and Swedish governments’ very different responses to the pandemic, despite grounding their decisions on largely the same scientific evidence and advice. Contrast is made by comparison with another SSI, anthropogenic global warming (AGW). It is argued that the exchange and combination of didactic models from the two fields may open new spaces for cross-pollination and cross-fertilisation to the mutual benefit of both science education and science communication.
Causal Mapping as a Teaching Tool for Reflecting on Causation in Human Evolution
Authors: Hanisch Susan , Eirdosh Dustin 
Published: September 2020

AbstractTeleological reasoning is viewed as a major hurdle to evolution education, and yet, eliciting, interpreting, and reflecting upon teleological language presents an arguably greater challenge to the evolution educator and researcher. This article argues that making explicit the role of behavior as a causal factor in the evolution of particular traits may prove productive in helping students to link their everyday experience of behavior to evolutionary changes in populations in ways congruent with scientific perspectives. We present a teaching tool, used widely in other parts of science and science education, yet perhaps underutilized in human evolution education—the causal map—as a novel direction for driving conceptual change in the classroom about the role of organism behavior and other factors in evolutionary change. We describe the scientific and conceptual basis for using such causal maps in human evolution education, as well as theoretical considerations for implementing the causal mapping tool in human evolution classrooms. Finally, we offer considerations for future research and educational design.
Targeting Policies for Multidimensional Poverty and Social Fragility Relief Among Migrants in Italy, Using F-FOD Analysis
Authors: Rimoldi Stefania M. L. , Arcagni Alberto , Fattore Marco , Barbiano di Belgiojoso Elisa 
Published: September 2020

AbstractIn this paper, we apply the novel Fuzzy First-Order Dominance (F-FOD) methodology to rank migrant subpopulations in Lombardy (Italy), in terms of multidimensional poverty and social fragility, for the year 2014, with the purpose to possibly provide useful support to policy-makers, in targeting relief interventions from poverty and discomfort. The F-FOD methodology allows for the direct comparison of different distributions of poverty and fragility, assessed by means of suitable ordinal multi-indicator systems, so extending to this more complex setting, the usual univariate first-order dominance criterion. It also provides complimentary “incomparability” scores, to assess to what extent the final rankings are reliable or instead forcing. It turns out that the levels of poverty and fragility of migrant subpopulations are quite different and, in particular, that the time since migrations has a key impact, on the identification of most critical cases, which typically involve recently migrated people. Evidence also emerges that the temporal poverty/fragility trajectories of migrants, distinguished by country of origin, follow different paths, suggesting how policy interventions must be properly, and differently, tuned to be effective.
A Humean modal epistemology
Authors: Dohrn Daniel 
Published: September 2020

AbstractI present an exemplary Humean modal epistemology. My version takes inspiration from but incurs no commitment to both Hume’s historical position and Lewis’s Humeanism. Modal epistemology should meet two challenges: the Integration challenge of integrating metaphysics and epistemology and the Reliability challenge of giving an account of how our epistemic capacities can be reliable in detecting modal truth. According to Lewis, modal reasoning starts from certain Humean principles: there is only the vast mosaic of spatiotemporally distributed local matters of fact. The facts can be arbitarily recombined. These principles cannot be taken for granted. I suggest a bottom-up approach instead: Humean principles of recombining the mosaic of facts can be retrieved from the evolutionarily instilled and empirically informed use of imagination in exploring everyday circumstantial possibilities. This use of imagination conforms to a primitive conception of matter as freely recombinable. The modal beliefs that can be obtained from generalizing the more elementary exercise of imagination have to be corrected. Recombination is limited by sortal criteria of identity. Moreover, the overall picture of a recombinable spatiotemporal mosaic must be weighed against the results of science.
Extreme sports performance for more than a week with severely fractured sleep
Authors: Netzer Nikolaus C. , Rausch Linda K. , Gatterer Hannes , Burtscher Martin , Eliasson Arn H. , Pramsohler Stephan 
Published: September 2020

Abstract
Purpose
Severely fractured sleep is mostly portrayed negatively, but investigations in extreme sports show that humans can maintain performance with a minimum of sleep. With two cases of long-lasting extreme sports performances, we demonstrate that severely fragmented sleep does not necessarily lead to a deterioration of physical and cognitive performance.

Methods
We performed continuous polysomnography on a 34 year-old skier for 11 days and nights during a world record attempt in long-term downhill skiing and monitored a 32 year-old cyclist during the Race Across America for 8.5 days via sleep and activity logs.

Results
The skier slept fractured fashion in 15–16 naps with a daily average of 6 h consisting of 77% in sleep stage 1 and 2, 11% in stage 3, and 13% in stage REM. The cyclist slept a total of 7 h and 52 min in 8.5 days, split up into 11 short naps and 6 sleep periods. The average duration of napping was 8.8 min and of sleep 64.2 min.

Conclusions
These two cases demonstrate that outstanding performances are possible with severely fractured sleep and/or sleep deprivation. In well-trained athletes, breaking new recordsis possible despite extreme sleep habits.
Beyond Serrated Flow in Bulk Metallic Glasses: What Comes Next?
Authors: Maaß R. 
Published: September 2020

Abstract
This manuscript is based on an oral contribution to the TMS 2020 annual meeting and is dedicated to Prof. Peter Liaw, who for decades has shown great interest in serrated plastic flow. Here we will focus on the case of bulk metallic glasses, and begin with briefly summarizing some aspects of serrated and non-serrated inhomogeneous flow—a phenomenon that has perplexed materials scientists for decades. Four directions of research are identified that emerged out of the desire to fundamentally understand the intermittent inhomogeneous flow response. These research directions gear away from the phenomenological stress–strain behavior but put the underlying shear defect into focus. Unsolved problems and future research topics are discussed.
Neuroinflammation associates with antioxidant heme oxygenase-1 response throughout the brain in persons living with HIV
Authors: Gruenewald Analise L. , Garcia-Mesa Yoelvis , Gill Alexander J , Garza Rolando , Gelman Benjamin B. , Kolson Dennis L. 
Published: September 2020

AbstractPrevious studies showed that persons living with HIV (PLWH) demonstrate higher brain prefrontal cortex neuroinflammation and immunoproteasome expression compared to HIV-negative individuals; these associate positively with HIV levels. Lower expression of the antioxidant enzyme heme oxygenase 1 (HO-1) was observed in PLWH with HIV-associated neurocognitive impairment (HIV-NCI) compared to neurocognitively normal PLWH. We hypothesized that similar expression patterns occur throughout cortical, subcortical, and brainstem regions in PLWH, and that neuroinflammation and immunoproteasome expression associate with lower expression of neuronal markers. We analyzed autopsied brains (15 regions) from 9 PLWH without HIV-NCI and 7 matched HIV-negative individuals. Using Western blot and RT-qPCR, we quantified synaptic, inflammatory, immunoproteasome, endothelial, and antioxidant biomarkers, including HO-1 and its isoform heme oxygenase 2 (HO-2). In these PLWH without HIV-NCI, we observed higher expression of neuroinflammatory, endothelial, and immunoproteasome markers in multiple cortical and subcortical regions compared to HIV-negative individuals, suggesting a global brain inflammatory response to HIV. Several regions, including posterior cingulate cortex, globus pallidus, and cerebellum, showed a distinct pattern of higher type I interferon (IFN)-stimulated gene and immunoproteasome expression. PLWH without HIV-NCI also had (i) stable or higher HO-1 expression and positive associations between (ii) HO-1 and HIV levels (CSF, plasma) and (iii) HO-1 expression and neuroinflammation, in multiple cortical, subcortical, and brainstem regions. We observed no differences in synaptic marker expression, suggesting little, if any, associated neuronal injury. We speculate that this may reflect a neuroprotective effect of a concurrent HO-1 antioxidant response despite global neuroinflammation, which will require further investigation.
What Factors Explain the Decline in Widowed Women’s Poverty?
Authors: Munnell Alicia H. , Sanzenbacher Geoffrey , Zulkarnain Alice 
Published: September 2020

AbstractHistorically, women in widowhood in the United States have been vulnerable, with high rates of poverty. However, over the past several decades, their poverty rate has fallen considerably. In this article, we look at why this decline occurred and whether it will continue. Using data from the Health and Retirement Study linked to Social Security administrative earnings and benefit records, we address these questions by exploring three factors that could have contributed to this decline: (1) women’s rising levels of education; (2) their increased attachment to the labor force; and (3) increasing marital selection, reflecting that whereas marriage used to be equally distributed, it is becoming less common among those with lower socioeconomic status. The project decomposes the share of the decline in poverty into contributions by each of these factors and also projects the role of these factors in the future. The results indicate that increases in education and work experience have driven most of the decline in widows’ poverty to date, but that marital selection will likely play a large role in a continuing decline in the future. Still, even after these effects play out, poverty among widows will remain well above that of married women.
Niet-spierinvasief en spierinvasief blaascarcinoom
Authors: de Vries Lieke , Witjes Fred 
Published: September 2020

SamenvattingBlaasspoelingen met Bacillus Calmette-Guérin (BCG) is de standaardbehandeling voor hooggradig (HG) NMIBC. Er is echter een wereldwijd tekort aan BCG. Daarnaast is er voor patiënten die falen op BCG-therapie geen goed alternatief, behoudens een radicale cystectomie. Daarom was er op de EAU veel aandacht voor onderzoek naar gereduceerde behandelschema’s met BCG en nieuwe behandelvormen voor de laatstgenoemde groep. drs. Lieke de Vries aios urologie
Controverses, complicaties en nieuwe technieken in nierchirurgie
Authors: de Vries A.H. , Zondervan Patricia J. , Beerlage Harrie P. 
Published: September 2020

SamenvattingSinds de introductie van minimaal-invasieve chirurgie (MIS) in de jaren ‘90 van de vorige eeuw heeft de nierchirurgie een enorme vlucht genomen. Na de eerste laparoscopische nefrectomie in 1990 door Ralph Clayman volgde in 2001 de eerste robotgeassisteerde nefrectomie door Bertrand Guillonneau. Inmiddels wordt in Nederland de nierchirurgie grotendeels minimaal-invasief uitgevoerd.
Global pandemic: consulting strategies in managing dental patients
Authors: Loh Melissa , Loh Declan , Loh William Y. C. 
Published: September 2020

AbstractDuring periods of pandemic disease, the practice of Dentistry must be altered incorporating the appropriate patient management strategies to reduce the transmission of disease. This article will outline the roles of remote consultations including virtual out-patient clinic appointments, telephone conversations and secure video networking systems to provide optimum patient-centered care.
Spain, Catalonia, and the Supposed Authority of the Judiciary
Authors: Helmich Maurits 
Published: September 2020

AbstractNormative literature on the Catalan crisis is largely occupied with the conflict’s central legalistic problem: can political units like Catalonia be allowed to split off from Spain unilaterally? This article reframes the issue and asks why secessionist Catalans should ever abide by Spanish legal constraints, given that Spanish law is precisely the institution they are politically trying to get rid of. It focuses on the anti-secessionist role played by the Spanish Constitutional Court between 2010 and 2017 and studies three arguments why Catalans supposedly have to accept the Court’s authority. The article contends that two arguments—the “mutual benefit argument” and the “law and democracy” argument—will not be independently persuasive to Catalan secessionists. Instead, the Constitutional Court’s authority must ultimately be grounded in a different type of argument: the “law and order argument.” Secessionist Catalans’ supposed duty to obey the orders of the Constitutional Court is ultimately not rooted in a positive service provided by the Court, but in the disruptive effects of disobeying. That exposes an explanatory defect in Joseph Raz’s influential theory of authority, which seeks to ground authority exercises in a concept in prior reason or their capacity to make our life better. That conceptualization misses the key decisionistic element to political authority: its capacity to constitute our reasons, that is, to define the terms that give meaning to our evaluations.