bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term Complications of Palate Surgery: A Multicenter Study of 217 Patients
Authors: Pang Kenny P. , Vicini Claudio , Montevecchi Filippo , Piccin Ottavio , Chandra Sudipta , Yang Hyung C. , Agrawal Vikas , Chung Joseph C. K. , Chan Yiong H. , Pang Scott B. , Pang Kathleen A. , Pang Edward B. , Rotenberg Brian 
Published: November 2019

Objectives/HypothesisTo investigate long‐term complications of newer reconstructive palate surgery techniques.Study DesignRetrospective case‐series analysis.MethodsRetrospective six‐country clinical study of OSA patients who had nose and palate surgery.ResultsThere were 217 patients, mean age = 43.9 ± 12.5 years, mean body mass index = 25.9 ± 4.7, mean preoperative apnea‐hypopnea index [AHI] = 30.5 ± 19.1, follow‐up 41.3 months. A total of 217 palatal procedures were performed, including 50 expansion sphincter pharyngoplasties (ESP), 34 functional expansion pharyngoplasties (FEP), 40 barbed reposition pharyngoplasties (BRP), 64 modified uvulopalatopharyngoplasties (mUPPP), 11 uvulopalatal flap procedures (UPF), nine suspension pharyngoplasties (SP), eight relocation pharyngoplasties (RP), and one z‐pharyngoplasty (ZPP). Complications included were constant and/or felt twice per week; dry throat (7.8%), throat lump feeling (11.5%), throat phlegm (10.1%), throat scar feeling (3.7%), and difficulty swallowing (0.5%). Of the 17 patients who had a dry throat complaint, two were constant (one SP, one RP), 15 were occasional (10 mUPPP, three SP, two BRP). Of the 25 patients with the throat lump feeling, four were constant (three RP, one ZPP), 21 were occasional (10 mUPPP, five SP, five UPF, one BRP). Of the 22 patients with the throat phlegm feeling, four were constant (two SP, two RP), 18 were occasional (10 mUPPP, four BRP, two FEP, two SP). Of the eight patients with throat scar feeling, eight were occasional (four SP, two mUPPP, one FEP, one RP), none were constant. One patient had difficulty swallowing (RP procedure). There was no velopharyngeal incompetence, taste disturbance, nor voice change. Highest symptom complaints were mUPPP, SP, and RP, whereas the lowest symptom complaint was ESP.ConclusionsNewer palatal techniques have shown to have less long‐term complications compared to the older ablative techniques.Level of Evidence4 Laryngoscope, 130:2281–2284, 2020
A multicriteria approach based on Analytic Hierarchy Process and compromise programming in portfolio selection
Authors: Santamaría Rafael , Aguarón Juan , Moreno‐Jiménez José María 
Published: November 2019

AbstractThe traditional approach to the portfolio selection problem, the mean‐variance model, shows limitations because it assumes that any investment opportunity could be meaningfully measured in terms of means and variances of returns. The model should include other criteria, based on liquidity, the characteristics of return distributions, or environmental factors. To incorporate in the model these additional relevant aspects of the problem, alternative methodologies are needed. This paper deals with the problem by using a multicriteria approach based on compromise programming and various options to incorporate the prior information (the norm and the criteria weights). A simplified version of the model has been applied to the stocks included in the Madrid Stock Market IBEX35 index. This article is dedicated to the memory of our colleague and friend Professor Rafael Santamaría, one of the most brilliant Spanish Professors of Finance, who passed away on June 18, 2018, at the age of 57.
Magnetic resonance imaging of mean cell size in human breast tumors
Authors: Xu Junzhong , Jiang Xiaoyu , Li Hua , Arlinghaus Lori R. , McKinley Eliot T. , Devan Sean P. , Hardy Benjamin M. , Xie Jingping , Kang Hakmook , Chakravarthy A. Bapsi , Gore John C. 
Published: November 2019

PurposeCell size is a fundamental characteristic of all tissues, and changes in cell size in cancer reflect tumor status and response to treatments, such as apoptosis and cell‐cycle arrest. Unfortunately, cell size can currently be obtained only by pathological evaluation of tumor tissue samples obtained invasively. Previous imaging approaches are limited to preclinical MRI scanners or require relatively long acquisition times that are impractical for clinical imaging. There is a need to develop cell‐size imaging for clinical applications.MethodsWe propose a clinically feasible IMPULSED (imaging microstructural parameters using limited spectrally edited diffusion) approach that can characterize mean cell sizes in solid tumors. We report the use of a combination of pulse sequences, using different gradient waveforms implemented on clinical MRI scanners and analytical equations based on these waveforms to analyze diffusion‐weighted MRI signals and derive specific microstructural parameters such as cell size. We also describe comprehensive validations of this approach using computer simulations, cell experiments in vitro, and animal experiments in vivo and demonstrate applications in preoperative breast cancer patients.ResultsWith fast acquisitions (~7 minutes), IMPULSED can provide high‐resolution (1.3 mm in‐plane) mapping of mean cell size of human tumors in vivo on clinical 3T MRI scanners. All validations suggest that IMPULSED provides accurate and reliable measurements of mean cell size.ConclusionThe proposed IMPULSED method can assess cell‐size variations in tumors of breast cancer patients, which may have the potential to assess early response to neoadjuvant therapy.
Effect of mouse strain and diet on feasibility of MRI‐based cell tracking in the liver
Authors: Mallett Christiane L. , Hix Jeremy M. L. , Kiupel Matti , Shapiro Erik M. 
Published: November 2019

PurposeMRI‐based cell tracking identifies the location of magnetically labeled cells with hypointense voxels. Here we demonstrate a strain‐dependent effect of liver MRI background on the feasibility of MRI‐based cell tracking of transplanted cells in the mouse liver.MethodsFVB mice (GFP‐LUC and NOG) and C57BL/6 mice (GFP+ and wild‐type) were fed 3 different diets with varying iron content. In vivo ‐weighted images and maps of the liver were acquired at different ages. Magnetically labeled cancer cells were injected intrasplenically for hepatic migration; then, mice were imaged by in vivo MRI and bioluminescence imaging. Livers were also imaged ex vivo by magnetic particle imaging.Results increased with age in FVBNOG and FVBGFP‐LUC mice that were fed diets sufficient in iron. FVBNOG mice developed a mottled appearance in their livers with age that did not occur in FVBGFP‐LUC mice. was unchanging with age in C57BL/6GFP mice, and the liver remained bright and homogenous. Labeled cells were not detectable by MRI in some livers despite successful engraftment as shown by bioluminescence imaging and magnetic particle imaging.ConclusionStrain, diet, and age are important considerations for MRI‐based cell tracking in the liver. If a model with excessive liver iron must be used, alternative imaging methods such as magnetic particle imaging can be considered.
Magnetization transfer in magnetic resonance fingerprinting
Authors: Hilbert Tom , Xia Ding , Block Kai Tobias , Yu Zidan , Lattanzi Riccardo , Sodickson Daniel K. , Kober Tobias , Cloos Martijn A. 
Published: November 2019

PurposeTo study the effects of magnetization transfer (MT, in which a semi‐solid spin pool interacts with the free pool), in the context of magnetic resonance fingerprinting (MRF).MethodsSimulations and phantom experiments were performed to study the impact of MT on the MRF signal and its potential influence on T1 and T2 estimation. Subsequently, an MRF sequence implementing off‐resonance MT pulses and a dictionary with an MT dimension, generated by incorporating a two‐pool model, were used to estimate the fractional pool size in addition to the , T1, and T2 values. The proposed method was evaluated in the human brain.ResultsSimulations and phantom experiments showed that an MRF signal obtained from a cross‐linked bovine serum sample is influenced by MT. Using a dictionary based on an MT model, a better match between simulations and acquired MR signals can be obtained (NRMSE 1.3% vs. 4.7%). Adding off‐resonance MT pulses can improve the differentiation of MT from T1 and T2. In vivo results showed that MT affects the MRF signals from white matter (fractional pool‐size ~16%) and gray matter (fractional pool‐size ~10%). Furthermore, longer T1 (~1060 ms vs. ~860 ms) and T2 values (~47 ms vs. ~35 ms) can be observed in white matter if MT is accounted for.ConclusionOur experiments demonstrated a potential influence of MT on the quantification of T1 and T2 with MRF. A model that encompasses MT effects can improve the accuracy of estimated relaxation parameters and allows quantification of the fractional pool size.
MYC2 regulates ARR16, a component of cytokinin signaling pathways, in Arabidopsis seedling development
Authors: Srivastava Archana Kumari , Dutta Siddhartha , Chattopadhyay Sudip 
Published: November 2019

AbstractMYC2 is a basic helix‐loop‐helix transcription factor that acts as a repressor of blue light‐mediated photomorphogenic growth; however, it promotes lateral root formation. MYC2 also regulates different phytohormone‐signaling pathways in crucial manner. Arabidopsis response regulator 16 (ARR16) is a negative regulator of cytokinin signaling pathways. Here, we show that MYC2 directly binds to the E‐box of ARR16 minimal promoter and negatively regulates its expression in a cytokinin‐dependent manner. While ARR16 and MYC2 influence jasmonic acid and cytokinin signaling, the expression of ARR16 is regulated by cry1, GBF1, and HYH, the components of light signaling pathways. The transgenic studies show that the expression of ARR16 is regulated by MYC2 at various stages of development. The mutational studies reveal that ARR16 positively regulates the hypocotyl growth in blue light, and phenotypic analysis of atmyc2 arr16 double mutant further reveals that arr16 can suppress the short hypocotyl phenotype of atmyc2. Altogether, this work highlights MYC2‐mediated transcriptional repression of ARR16 in Arabidopsis seedling development.
Comparisons of outlier tests for potency bioassays
Authors: Sondag Perceval , Zeng Lingmin , Yu Binbing , Yang Harry , Novick Steven 
Published: November 2019

SummaryPotency bioassays are used to measure biological activity. Consequently, potency is considered a critical quality attribute in manufacturing. Relative potency is measured by comparing the concentration‐response curves of a manufactured test batch with that of a reference standard. If the curve shapes are deemed similar, the test batch is said to exhibit constant relative potency with the reference standard, a critical requirement for calibrating the potency of the final drug product. Outliers in bioassay potency data may result in the false acceptance/rejection of a bad/good sample and, if accepted, may yield a biased relative potency estimate. To avoid these issues, the USP<1032> recommends the screening of bioassay data for outliers prior to performing a relative potency analysis. In a recently published work, the effects of one or more outliers, outlier size, and outlier type on similarity testing and estimation of relative potency were thoroughly examined, confirming the USP<1032> outlier guidance. As a follow‐up, several outlier detection methods, including those proposed by the USP<1010>, are evaluated and compared in this work through computer simulation. Two novel outlier detection methods are also proposed. The effects of outlier removal on similarity testing and estimation of relative potency were evaluated, resulting in recommendations for best practice.
Theoretical modeling of the chemical synthesis and detonation performance of polynitrocubane derivatives
Authors: Liu Min‐Hsien , Lin Chun‐Chih 
Published: November 2019

AbstractTheoretical work was performed based on experimental methods described in the literature to simulate and explore feasible routes for the synthesis of energetic octanitrocubane (ONC) and polynitrocubane derivatives. In respective gaseous and liquidous environments, using cubane as the raw material, ONC was successfully synthesized through carboxylation, amination, oxidation and nitration stages, and the related reaction energy barriers were simultaneously acquired. In particular, the polyparametric calibrated gaseous molecular formation enthalpy and the group additivity approach‐estimated molecular density were incorporated using the Kamlet‐Jacobs equation to evaluate the detonation performance of polynitrocubane derivatives. Some high‐energy‐density derivatives were found to have superior characteristics as compared with traditional hexagon (RDX) and octagon (HMX) explosives.
Clinical outcomes of MII oocytes with refractile bodies in patients undergoing ICSI and single frozen embryo transfer
Authors: Takahashi Hiromi , Otsuki Junko , Yamamoto Michio , Saito Hiroe , Hirata Rei , Habara Toshihiro , Hayashi Nobuyoshi 
Published: November 2019

AbstractPurposeThis study aimed to analyze whether the presence of refractile bodies (RFs) negatively affects fertilization, embryo development, and/or implantation rates following intracytoplasmic sperm injection (ICSI).MethodsThis retrospective embryo cohort study involved a total of 272 patients undergoing ICSI treatment of blastocyst cryopreservation.ResultsIn the study, no significant differences were found regarding 2PN formation rates between RF(+) (76.5%) and RF(−) oocytes (77.2%). However, the blastocyst formation rate on Day 5 in RF(+) oocytes was 45.8%, which was significantly lower than that of 52.2% in RF(−) oocytes (aOR 0.74, 95% CI 0.59‐0.93, P = .011). Implantation rates were also significantly lower in RF(+) oocytes (24.2%) as compared to RF(−) oocytes (42.2%) (aOR 0.46, 95% CI 0.26‐0.78, P = .005). Furthermore, the implantation rate of RF(+) oocytes (28.6%), when high‐quality blastocysts were transferred, was significantly lower than that of RF(−) oocytes (46.1%) (aOR 0.50, 95% CI 0.25‐0.96, P = .043).ConclusionOur results suggest that oocytes with the presence of RFs have a lower potential for blastocyst development. Even when they develop into high‐quality blastocysts, the chances of implantation are reduced.
Towards the implementation of advanced random access schemes for satellite IoT
Authors: Krondorf Marco , Goblirsch Martin , de Gaudenzi Riccardo , Cocco Giuseppe , Toptsidis Nikolaos , Acar Guray 
Published: November 2019

SummaryMachine‐to‐machine (M2M) communications being pivotal for internet of things (IoT) networks are characterized by low‐cost, low complexity, and often energy constrained terminals with low traffic duty cycle. Satellite networks provide an attractive low‐cost solution for such application, in particular when the terminals (both fixed and mobile) are distributed over a wide geographical area not well served by terrestrial infrastructure. An ALOHA random access (RA) scheme is a natural candidate for M2M communications since it is well matched to sporadic traffic, and it requires little terminals coordination. However, the classical ALOHA scheme suffers from a low throughput when operated in a load region requiring low probability of packet loss. To overcome this intrinsic ALOHA limitation, in the last decade, a lot of effort has been devoted to the investigation of evolutions of the ALOHA scheme reducing the probability of destructive packet collisions thus making it more attractive for satellite IoT. In such context, the Contention Resolution Diversity ALOHA (CRDSA) scheme and the Asynchronous Contention Resolution Diversity ALOHA (ACRDA) have emerged as promising solutions thanks to their high spectral efficiency achievable with low packet loss probability. The results reported in literature are however assuming ideal demodulator performance. This paper investigates the design and optimization of RA burst demodulator algorithms for single‐frequency and multifrequency CRDSA and ACRDA. It evaluates the performance of such algorithms in a number of system scenarios of practical interest and studies the impact of relevant system parameters on several performance metrics.
Active Innovative Media as Co‐Evolutionary Landscapes
Authors: Knyazeva Helena 
Published: November 2019

AbstractSome conceptual and methodological foundations of effective construction of active media for innovative development are developed in the article. The ideas of global evolutionism (or universal evolutionism), ecology understood in an extended sense, emergentism, time management, and the constructing the desirable futures are used as methodologically key ones. Evolutionism is understood in a broader sense than in the Darwin era, when it included the idea of multiplying the primary diversity of elements of living media and natural selection of the most viable forms of life based on this diversity. The modern evolutionism is founded mostly on the theory of complexity and non‐linear dynamics and includes the ideas cyclical evolution that is uneven in its pace, the appearance of emergent properties of systems at different hierarchical levels that come into existence in the course of evolution, the mutual activity of a system and its environment (active adaptation and enactive behaviour), the possibility and expediency of the influence of subjects of social action, and management on the course of evolutionary processes in complex active media (the choice of favourable evolutionary paths near points of instability, construction of trends, and future management).
Flammrichten normal‐ und hochfester Baustähle
Authors: Feldmann Markus , Schäfer Dirk 
Published: November 2019

AbstractBedingt durch ein großes Parameterfeld und instationäre Temperatur‐ und Dehnungsverteilungen erscheint der Prozess des Flammrichtens relativ komplex. So basiert das Flammrichten bis heute insbesondere hinsichtlich der erzielbaren Verformungen eher auf – wenn auch plausiblen – Erfahrungswerten als auf ingenieurtechnischen Ansätzen. Hinsichtlich der Materialbeeinflussung existieren hingegen technische Regeln, die Festigkeits‐ und Zähigkeitseinbußen ausschließen sollen. Bei Einsatz hochfester Sorten verändern sich jedoch die Verhältnisse im Vergleich zu normalfesten Stählen, denn mit zunehmender Streckgrenze werden die erzielbaren Verformungen kleiner. Zum Ausgleich dieses Effekts werden oft höhere Temperaturen und Haltezeiten gewählt, was jedoch das Risiko einer Materialbeeinflussung erhöht. Für das Flammrichten hoch‐ und höchstfester Stähle sind also solche Konstellationen zu erforschen, die zu einem nach wie vor einfachen und sicheren Ergebnis führen. Dies zeigt der vorliegende Beitrag in zwei Teilen, indem er die werkstofftechnischen Mechanismen für das Flammrichten auch bei hohen Streckgrenzen klärt. Ausgehend davon werden Anwendungskorridore abgeleitet und Vorschläge für die Verbesserung bestehender Regeln gemacht.Im ersten Teil dieses Beitrags in der Stahlbau [1] wurden das Prinzip des Flammrichtens normal‐ und hochfester Stähle nebst den Zusammenhängen zwischen Thermodynamik, Metallurgie und Mechanik vorgestellt sowie die experimentelle und numerische Ermittlung des Wärmeeintrags und der Temperaturfelder gezeigt.Der nun vorliegende zweite Teil widmet sich den Verformungen und Zwangsmomenten aus dem Flammrichtprozess, der Beeinflussung des Materials durch die Temperaturzyklen und einem Beispiel zur Vorhersage der Flammrichtergebnisse.
Betrachtungen zur Interaktion von Biegung und Querdruck bei Sandwichelementen
Authors: Nelke Harald , Lange Jörg 
Published: November 2019

AbstractDie Interaktion von Biegung und Querdruck wird bei Sandwichelementen im Versuch bestimmt. Dafür sieht die aktuelle Normung, DIN EN 14509 [1], einen 3‐Punkt‐Biegeversuch vor, bei dem die Spannweite indirekt von der Paneeldicke abhängt. Die Spannweite ist ein entscheidender Einflussfaktor, da sie das Verhältnis zwischen Biegung und Querdruck bestimmt. Aus diesem Grund wurde untersucht, wie groß die Spannweite sein müsste, damit reale Systeme vollständig abgebildet werden. Die dafür durchgeführte Parameterstudie kam zu dem Ergebnis, dass die Spannweite im Ersatzträgerversuch zwischen 1 m und 12 m liegen müsste, um realistische Ergebnisse zu erhalten. DIN EN 14509 [1] führt dagegen zu Spannweiten, die zumeist zwischen 4 m und 6 m liegen. Zur Einordnung dieser Diskrepanz wurden Versuchsergebnisse der Autoren herangezogen [2–5]. Die Über‐ bzw. Unterschätzung der Spannweite führt demnach beim Gebrauchstauglichkeitsnachweis zu Abweichungen von bis zu ± 20 % (Wand) bzw. ± 30 % (Dach). Abschließend wird eine Handlungsempfehlung gegeben, wie mit diesen Abweichungen in der praktischen Bemessung umgegangen werden sollte.
Effect of polymer modified cementitious coatings on chloride‐induced corrosion of steel in concrete
Authors: Brenna Andrea , Beretta Silvia , Berra Mario , Diamanti Maria Vittoria , Ormellese Marco , Pastore Tommaso , Pedeferri MariaPia , Bolzoni Fabio 
Published: November 2019

AbstractThe paper deals with the study of the effect of polymer modified cementitious mortars on chloride‐induced corrosion of steel reinforcement in concrete. Nowadays, many results obtained by standard and short‐term tests are available in the literature. The paper reports more than 15 years exposure testing on two commercial coatings, with different polymer/cement ratio. The effect of coatings on corrosion initiation and propagation has been studied by the monitoring of corrosion potential and corrosion rate of rebars in concrete subjected to chloride ponding; chloride profiles, coating adhesion, water content, and corrosion morphology have been also analyzed. It was demonstrated that polymer modified cementitious mortars can delay corrosion initiation caused by chloride penetration into concrete. Owing to high resistivity of coated concrete, corrosion rate is reduced. The protective effect is more pronounced as the polymer content increases from 0.35 to 0.55. The results have been elaborated to estimate the possible increase of service life gained with this additional protection method, compared with other solutions.
Investigation of mechanical and thermal properties of nano SiO2/hydrophobic silica aerogel co‐doped concrete with thermal insulation properties
Authors: Al Zaidi I. Kadum , Demirel Bilal , Atis Cengiz D. , Akkurt Fatih 
Published: November 2019

AbstractLightweight concretes with thermal insulation properties and good compressive strength can be produced by the replacement of normal aggregate of cement mixture with low‐density materials. In this study, sand in a cement mixture has been replaced totally with silica aerogel powder as well as replacement of cement with fly ash. Furthermore, nano silica and silica‐fume were added and incorporated into the concrete matrix. The most obvious finding to emerge from this study was that a lighter sample with no sand contributed to the lowest thermal insulation reduction by 58% of the reference sample and reduction in density to 22.8%, with reduced compressive strength of 27.11 MPa at 28 days. Obtaining of a lighter concrete by using aerogel, a chance of reduced building cooling and heating energy consumption and enhanced indoor comfort with the reduction of mold and condensation on buildings wall was obtained.