bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ovarian Dysfunction Induced by Chronic Whole‐Body PM2.5 Exposure
Authors: Zhou Su , Xi Yueyue , Chen Yingying , Zhang Zezhong , Wu Chunyan , Yan Wei , Luo Aiyue , Wu Tong , Zhang Jinjin , Wu Meng , Dai Jun , Shen Wei , Zhang Fang , Ding Wenjun , Wang Shixuan 
Published: July 2020

AbstractFine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases the risk of female infertility. However, relatively few studies have systematically explored the harmful effect of chronic PM2.5 exposure on ovarian function and the underlying mechanisms. In this study, female C57BL/6J mice are exposed to filtered air or urban airborne PM2.5 for 4 months through a whole‐body exposure system. It is found that PM2.5 exposure significantly caused the alteration of estrus cycles, reproductivity, hormone levels, and ovarian reserve. The granulosa cell apoptosis via the mitochondria dependent pathway contributes to the follicle atresia. With RNA‐sequencing technique, the differentially expressed genes induced by PM2.5 exposure are mainly enriched in ovarian steroidogenesis, reactive oxygen species and oxidative phosphorylation pathways. Furthermore, it is found that increased PM2.5 profoundly exacerbated ovarian oxidative stress and inflammation in mice through the NF‐κB/IL‐6 signaling pathway. Notably, dietary polydatin (PD) supplement has protective effect in mice against PM2.5‐induced ovarian dysfunction.These striking findings demonstrate that PM2.5 and/or air pollution is a critical factor for ovarian dysfunction through mitochondria‐dependent and NF‐κB/IL‐6‐mediated pathway, and PD may serve as a pharmaceutic candidate for air pollution‐associated ovarian dysfunction.
Genetic gains with rapid‐cycle genomic selection for combined drought and waterlogging tolerance in tropical maize (Zea mays L.)
Authors: Das Reshmi R. , Vinayan M. T. , Patel Manish B. , Phagna Ramesh K. , Singh S. B. , Shahi J. P. , Sarma Akashi , Barua N. S. , Babu Raman , Seetharam K. , Burgueño Juan A. , Zaidi P. H. 
Published: July 2020

AbstractRapid cycle genomic selection (RC‐GS) helps to shorten the breeding cycle and reduce the costs of phenotyping, thereby increasing genetic gains in terms of both cost and time. We implemented RC‐GS on two multi‐parent yellow synthetic (MYS) populations constituted by intermating ten elite lines involved in each population, including four each of drought and waterlogging tolerant donors and two commercial lines, with proven commercial value. Cycle 1 (C1) was constituted based on phenotypic selection and intermating of the top 5% of 500 S2 families derived from each MYS population, test‐crossed and evaluated across moisture regimes. C1 was advanced to the next two cycles (C2 and C3) by intermating the top 5% selected individuals with high genomic estimated breeding values (GEBVs) for grain yield under drought and waterlogging stress. To estimate genetic gains, population bulks from each cycle were test‐crossed and evaluated across locations under different moisture regimes. Results indicated that the realised genetic gain under drought stress was 0.110 t ha−1 yr−1 and 0.135 t ha−1 yr−1, respectively, for MYS‐1 and MYS‐2. The gain was less under waterlogging stress, where MYS‐1 showed 0.038 t ha−1 yr−1 and MYS‐2 reached 0.113 t ha−1 yr−1. Genomic selection for drought and waterlogging tolerance resulted in no yield penalty under optimal moisture conditions. The genetic diversity of the two populations did not change significantly after two cycles of GS, suggesting that RC‐GS can be an effective breeding strategy to achieve high genetic gains without losing genetic diversity.
Ecological Hope
Authors: Northcott Michael S. 
Published: July 2020

AbstractHorkeimer and Adorno, and later Lynn White Jr, blame the anti-animist strain in Western Christianity, its origination of the scientific and industrial revolutions, and the European Enlightenment, as the cultural roots of the ecological crisis. But evidence shows there is no necessary connection between animism and care for other kind. I propose that a more fruitful approach is to reconsider the post-Reformation and scientific eschewal of agency in nonhuman beings and ecosystems such as forests, rivers, and the oceans. Rediscovering the “agency of the others” is also essential as a means to resolve the ecological crisis, since humans alone cannot restore or “save” the Earth from the systemic effects of 200 years of industrial pollution and destruction of resilient biodiverse habitats. Christian eschatological hope has valuable resources for this approach including evidence that in the lives of the saints new friendships were formed between humans and other animals. Analogously, recent developments in ecological restoration and “rewilding” indicate a new peaceable partnership between humans and other kind and, in the light of Christian messianism, and the “theory of hope,” may be said to anticipate a wider ecological reconciliation between humans and other kind.
Post-Kantian to Postmodern Considerations of (Theological) Hope
Authors: Michener Ronald T. 
Published: July 2020

AbstractHope found in the rational, empirical, epistemological optimism of Enlightenment-based modernism attempted to detach itself from its religious, Christian roots. This chapter will focus on post-Kantian and postmodern sensibilities that reject the modernist “myth of neutrality” and return to the theological roots of hope, even when for some, particular theological or Christian beliefs are renounced. To consider this, the chapter will highlight themes of hope found in precursors to postmodern thought: Kierkegaard, Nietzsche, and Marcel. Next, it will turn to the postmodern Derridean hope of John D. Caputo and offer a glimpse of the pragmatic hope of Richard Rorty. This will be followed by a consideration of James K.A. Smith’s critique of Caputo and Rorty, and his proposal for a phenomenological, determined hope.
The Psychology of Hope: A Diagnostic and Prescriptive Account
Authors: Scioli Anthony 
Published: July 2020

AbstractIn this chapter, I review psychology’s contributions to the study of hope. To close potential gaps in this interdisciplinary volume, I include work in psychiatry and nursing. The nearly 400-year history of psychological reflections on hope reveals extended stretches of neglect, alternating with brief flashes of interest. Shifting scientific paradigms are partly to blame. However, I suggest that the greatest challenge for investigators seeking scientific consensus on the topic may be cultural and sociopolitical. I begin with a review of the most significant writings and research on hope, dating back to the seventeenth century. I examine goal-related approaches in greater depth, due to their strong influence on the field of psychology. The latter half of this chapter is more critical and prescriptive. For a deeper commentary, I rely on Markus’s (Meas Interdisciplinary Res Perspect 6:54–77, 2008) distinction between constructs and concepts as well as Danziger’s (Naming the mind: How psychology found its language. Sage Publications, 1997) observation on how psychology found its lexicon. This middle, diagnostic section includes a review of philosophy of science criteria for evaluating theories. I transition to general prescriptions for achieving a better understanding of hope, organized around Bacon’s “four idols” of the mind, and add specific suggestions for future research. I conclude with a summary of recent work within our hope lab.
Isolated high tibial osteotomy is appropriate in less than two-thirds of varus knees if excessive overcorrection of the medial proximal tibial angle should be avoided
Authors: Feucht Matthias J. , Winkler Philipp W. , Mehl Julian , Bode Gerrit , Forkel Philipp , Imhoff Andreas B. , Lutz Patricia M. 
Published: July 2020

AbstractPurposeTo perform a detailed deformity analysis of patients with varus alignment and to define the ideal osteotomy level (tibial vs. femoral vs. double level) to avoid an oblique joint line.MethodsA total of 303 digital full-leg standing radiographs of patients aged 18–60 years and varus alignment [mechanical tibiofemoral varus angle (mFTA) ≥ 3°] were included. All legs were analyzed regarding mFTA, mechanical medial proximal tibia angle (mMPTA), mechanical lateral distal femur angle (mLDFA), and joint line convergence angle. Based on mFTA, varus alignment was categorized as “mild” (3°–5°), “moderate” (6°–8°), or “severe” (≥ 9°). Deformity location was determined according to the malalignment test described by Paley. Two osteotomy simulations were performed with different upper limits for mMPTA: anatomic correction (mMPTA ≤ 90°, mLDFA ≥ 85°) and overcorrection (mMPTA ≤ 95°, mLDFA ≥ 85°). If a single osteotomy exceeded these limits at the intended mFTA of 2° valgus, a double-level osteotomy was simulated. If even a double-level osteotomy resulted in deviations from the defined limits, the leg was categorized as “uncorrectable”.ResultsMean mFTA was 6° ± 11° of varus (range 3°–15°). A tibial deformity was observed in 28%, a femoral deformity in 23%, a combined tibial and femoral deformity in 4%, and no bony deformity in 45%. The prevalence of a tibial deformity did not differ between varus severity groups, whereas a femoral and bifocal deformity was significantly more prevalent in knees with more distinct varus (p < 0.001). Osteotomy simulation revealed that isolated high tibial osteotomy (HTO) was appropriate in only 12% for anatomic correction, whereas a double-level osteotomy was necessary in 63%. If overcorrection of mMPTA was tolerated, the number of HTOs significantly increased to 57% (p < 0.001), whereas the number of double-level osteotomies significantly decreased to 33% (p < 0.001). Isolated DFO was considered ideal in 8% for both simulations. Significantly more knees were considered “uncorrectable” by simulating anatomic correction (18 vs. 2%;p < 0.001). A double-level osteotomy was significantly more often necessary in knees with “severe” varus (p < 0.001).ConclusionLess than one-third of patients (28%) with mechanical varus ≥ 3° have a tibial deformity. If anatomic correction (mMPTA ≤ 90°) is intended, only 12% of patients can be corrected via isolated HTO, whereas 63% of patients require a double-level osteotomy. If slight overcorrection is accepted (mMPTA ≤ 95°), 57% of patients can be corrected via isolated HTO, whereas 33% of patients would still require a double-level osteotomy.Level of evidenceIII, cross-sectional study.
A six-gene expression signature related to angiolymphatic invasion is associated with poor survival in laryngeal squamous cell carcinoma
Authors: Metzger Karl , Moratin Julius , Freier Kolja , Hoffmann Jürgen , Zaoui Karim , Plath Michaela , Stögbauer Fabian , Freudlsperger Christian , Hess Jochen , Horn Dominik 
Published: July 2020

Abstract
Purpose
Angiolymphatic invasion serves as a histopathological risk factor for unfavorable survival in head and neck squamous cell carinoma. The aim of the study was to explore the molecular mechanisms characterizing angiolymphatic invasion and therefore identify a gene expression signature related to angiolymphatic invasion.

Methods
Gene expression analysis of head and neck squamous cell carcinoma was carried out based on clinical and whole genome expression data provided by The Cancer Genome Atlas. Results were validated in an independent cohort of laryngeal squamous cell carcinoma and confirmed by immunohistochemistry staining.

Results
A gene expression signature consisting of six genes (SHH, SLC18A3, LCE3E, LCE2B, LCE3D and DSG-1) related to angiolymphatic invasion was identified. The gene expression profile identified a subset of patients with decreased overall survival (p = 0.02, log rank test), which was most prominent for patients with laryngeal squamous cell carcinoma (p = 0.004, log rank test). Furthermore, these patients showed a significant shorter progression-free survival (p = 0.002, log rank test). By use of this gene expression signature, patients at high risk of recurrence could be identified even if morphological changes were not yet recognizable.

Conclusion
Angiolymphatic invasion is characterized by a distinct histopathological phenotype and specific gene expression signature. The newly identified signature might serve as a reliable predictor of outcome in laryngeal cancer and add additional benefit to histopathological evaluation.
Constructions, their families and their neighborhoods: the case of durak durakom ‘a fool times two’
Authors: Janda Laura A. , Kopotev Mihail , Nesset Tore 
Published: July 2020

AbstractOn the basis of data from the Russian National Corpus, we analyze the meanings and structure of the syntactic construction observed in phrases likedurak durakom‘fool-nom.sgfool-ins.sg’, which we term the ‘NOM∼INS construction’. We argue that the construction constitutes a network of three closely related subcategories, which we refer to as ‘Extreme’, ‘Paragon’ and ‘Discourse Change’. It is furthermore shown that a diachronic change has taken place, whereby Discourse Change has overtaken Extreme as the dominant subcategory. Our analysis provides ample evidence for the main tenets of Construction Grammar, namely that a language is a network of related constructions, that meaning is often not compositional, that there is a continuum from idiomatic to schematic uses of constructions, and that constructions evolve over time.
Clinical outcomes after percutaneous coronary intervention for early versus late and very late stent thrombosis: a systematic review and meta-analysis
Authors: Yang Yi-Xing , Liu Yin , Li Xiao-Wei , Lu Peng-Ju , Wang Jiao , Li Chang-Ping , Gao Jing 
Published: July 2020

AbstractWhether the clinical outcomes of stent thrombosis (ST) are different when stratified by time of occurrence remains unclear. The objective of this study was to compare the short- and long-term clinical outcomes after percutaneous coronary intervention (PCI) for early stent thrombosis (EST) versus late stent thrombosis (LST) and very late stent thrombosis (VLST). We enrolled eligible studies searched from the main electronic databases (EMBASE, PubMed, Cochrane). The primary endpoints were in-hospital, 30-day, 1-year and long-term mortality. The secondary endpoints included recurrent stent thrombosis (RST) and target vessel/lesion revascularization (TVR/TLR) during hospitalization, at 30 days, at 1 year and at long-term follow-up. A total of 23 studies with 17,592 patients were included. Compared with mortality rates of the late and very late thrombosis (LST/VLST) group, in-hospital (P = 0.004), 30-day (P < 0.00001), 1-year (P < 0.00001) and long-term mortality rates (P = 0.04) were significantly higher in the EST group. The in-hospital TVR/TLR rates were similar between the EST group and the LST/VLST group. However, a higher trend in TVR/TLR rate at 30 days and a significantly higher TVR/TLR rate at 1 year (P = 0.002) as well as at long-term follow up (P = 0.009) were found in the EST group. EST patients also trended toward higher risk of RST in both short- and long-term follow-up than LST/VLST patients, although differences were not statistically significant. After PCI treatment, patients with EST have worse clinical outcomes in both short- and long-term follow-up than patients with LST/VLST. Further studies are warranted to determine the optimal treatment strategies for EST.
Numerical solution of a class of third order tensor linear equations
Authors: Simoncini V. 
Published: July 2020

AbstractWe propose a new dense method for determining the numerical solution to a class of third order tensor linear equations. The approach does not require the use of the coefficient matrix in Kronecker form, thus it allows the treatment of structured very large problems. A particular version of the method for symmetric matrices is also discussed. Numerical experiments illustrate the properties of the proposed algorithm.
Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
Authors: Klimek Ludger , Casper Ingrid , Bergmann Karl-Christian , Biedermann Tilo , Bousquet Jean , Hellings Peter , Jung Kirsten , Merk Hans , Olze Heidi , Mösges Ralph , Schlenter Wolfgang , Gröger Moritz , Ring Johannes , Chaker Adam , Pfaar Oliver , Wehrmann Wolfgang , Zuberbier Torsten , Becker Sven 
Published: July 2020

Abstract
Background
Allergic rhinitis (AR) continues to increase in incidence and is the most common allergic disease. If abstention of the allergen triggering substances is not possible, allergen-specific immunotherapy (AIT) as causal treatment or a drug therapy with mast cell stabilizers, antihistamines (AHs), glucocorticoids (GCs), leukotriene (LT) receptor antagonists and decongestants is indicated. Despite these diverse therapeutic options, studies on the real-life care situation of patients with AR regularly show that a considerable proportion of patients do not feel adequately treated with monotherapy of the usual drugs and therefore use several preparations with different active ingredients simultaneously and in various combinations. However, such parallel applications of several active ingredients are normally not tested in approval studies and therefore carry a potential risk of side effects or lack of efficacy.

Methods
For the present publication, a focused literature search in PubMed, Livivo and on the World Wide Web for the previous 20 years (period 01/1999 to 01/2020) was carried out. This literature search included original and review articles in German or English. A further analysis of current publications was also conducted for German-language journals that are not available in international literature databases.

Results
AHs and nasal GCs represent the therapeutic standard in AR. Their efficacy is well documented for several preparations. The evidence for combination therapies is documented very well for a fixed combination of azelastine and fluticasone (MP29-02). For the simultaneous use of non-fixed combined monopreparations, only a few efficacy and safety studies based on modern evidence criteria exist.

Conclusion
The free combination therapies of mast cell stabilizers, decongestants, AHs and nasal GCs, frequently used in the routine care of patients with AR, cannot be recommended because they are not evidence-based. Due to the fact that over-the-counter antiallergic drugs are not reimbursable in Germany, there is no medical supervision of the therapy. In addition, there are doubts about appropriate treatment, especially of patients with persistent rhinitis with severe symptoms, as these patients often use several preparations at the same time to alleviate their symptoms.
A Critical Review on the Ubiquitous Role of Filamentous Fungi in Pollution Mitigation
Authors: Ferreira Jorge A. , Varjani Sunita , Taherzadeh Mohammad J. 
Published: July 2020

AbstractPropose of ReviewAnthropogenic activities are saturating wastewater treatment plants and the environment with an increasing range of organic and inorganic compounds, impairing ecosystems and health. Filamentous fungi, with characteristic filamentous growth, array of extracellular and intracellular enzymes, production of surfactants, cell wall biosorption properties, and symbiotic momentum, can contribute to a paradigm shift on the perception of anthropogenic pollution. This review provides a critical analysis of the main bottlenecks for feasible filamentous fungus-including processes and proposes a holistic approach for pollution mitigation using filamentous fungi.Recent FindingsFilamentous fungi can convert ordinary sidestreams into, e.g., feed proteins and biofuels. Economic and environmental studies support integration in established processes. Intersectoral initiatives, and economic and environmental studies, need to be motivated to increase the range of processes. Although massively studied, the transfer of fungal processes for the removal of micropollutants into real matrices is difficult. It needs to be supported by omics technologies for the study of microbial networks, and by efficient analytical techniques to clarify detoxification potential. The area can benefit from knowledge integration from fungal growth in ordinary sidestreams, and from economic and environmental studies.SummaryThe interest in filamentous fungi for pollution mitigation is corroborated by an overwhelming amount of research; however, no full-scale applications are currently known. Environmental pollution is a reality and production of ordinary sidestreams and micropollutant-rich wastewaters continuous. The establishment of filamentous fungal processes needs collaboration among governmental authorities, industries, and academics in order to tackle knowledge gaps within the area and propose a holistic approach.
Effect of titanium oxide addition on magnesia refractories
Authors: Kusiorowski Robert 
Published: July 2020

AbstractThis work contains the results of investigations into the influence of titanium oxide (TiO2) addition on the properties of refractory magnesia ceramics. The presented research involved adding titanium oxide in a classic way, i.e. directly to the ceramic mix. The conducted laboratory tests revealed a significant impact of this oxide on the properties of refractory materials. Addition of a small amount of TiO2 favoured the ceramic mix sintering whereas adding a bigger amount—more than 10 wt% resulted in the formation of refractories characterised by considerable porosity and low mechanical strength. Addition of this oxide also slightly improves the corrosive resistance of refractories.
Long-Term Prospects for Landscape Mitigation Programs
Authors: Schlanger Sarah H. , Larralde Signa , Stein Martin 
Published: July 2020

ABSTRACTThe alternative mitigation program that the Bureau of Land Management (BLM) established in 2008 to address impacts to the archaeological resources in the Permian Basin of southeastern New Mexico, now one of the most active of the nation's oil and gas energy fields, has supported more than $10 million in field research programs and is poised to be able to fund about $1 million in field research annually for the foreseeable future. The financial success of the program is mirrored by the program's outstanding contributions to our understanding of the Permian Basin's long and complex history of human occupation. Surprisingly, although other public lands under the auspices of the BLM are seeing similar rates of energy development, the critical elements of this program have not been picked up elsewhere in the BLM. The Permian Basin program appears doomed to be an example of a “one-off” alternative mitigation solution. The factors barring more widespread adoption include the ebb and flow of energy production activity, complications arising from mixed land status and the ability to work across jurisdictional boundaries, hesitation to change procedures that are working adequately for the time being, and a lack of capacity to institute systemic change.