bluuebunny/crossref_metadata_2025_split huggingface dataset:
COX-1/EP1R&nbsp;Inhibition Ameliorate Deficits in Adult Neurogenesis and Social Interaction via Alleviating NLRP3/ IL-1β Activation During Hypobaric Hypoxia
Authors: Chauhan Garima , Kumar Gaurav , Roy Koustav , Kumari Punita , Alam Shahnawaz , Thondala Bhanuteja , Kishore Krishna , Panjwani Usha , Ray Koushik 
Published: October 2020

Abstract
BackgroundLow oxygen environments like hypobaric hypoxia (HH) are common nodes to various diseases: characterized by neuroinflammation, which is detrimental to the structural and functional aspects of hippocampal circuitry. Various hypoxic conditions also lead to elevation of NLRP3 mediated neuroinflammation that may contribute to cognitive deficits. Components of neurogenic niches like microglia and astrocyte are largely affected by neuroinflammation; however, a systematic investigation of the impact of NLRP3 mediated neuroinflammation on components of neurogenic niche during hypoxia (HH) remains elusive. MethodsIn this study, we simulated cerebral hypoxia via decreasing partial pressure of oxygen(HH). The effect of hypobaric hypoxic (1, 3 and 7 day at 25000 ft) on social memory, anxiety, adult neurogenesis change in the inflammatory milieu in DG was explored in detail. We explored the efficacy of COX-1 inhibitor (Valery salicylate, 5mg/kg/day,i.p), and EP1R antagonist (SC19220, 1mg/kg/day,i.p) on NLRP3 mediated neuroinflammation and associated maladies during HH. ResultsWe observed that HH exposure induced alteration in social and anxiety-like behavior post 7 day exposure along with perturbation in levels of BDNF, Serotonin and adult neurogenesis in the DG right from day 1. Moreover, significant elevated NLRP3, caspase-1, and IL-1β levels are observed during HH from day 1. Concomitantly, a notable increase in the COX-1/EP1 pathway in both activated microglia and astrocyte in DG was evident after 3HH exposure. Pharmacological COX-1 inhibitor and EP1 antagonist counteract the detrimental effects of HH exposure on social memory, adult neurogenesis, and NLRP3 inflammasome induction. ConclusionsThus, our data showed induction of the COX-1/EP1 pathway in glial cells is detrimental to adult neurogenesis and social memory, raising possibility that the COX-1/EP1 pathway as a plausible target for inflammasome related neurogenesis impairment.
WITHDRAWN: The Prevalence of Depression and Its Association With Quality of Life Among Pregnant and Postnatal Women in China: A Multicenter Study
Authors: Bo Haixin , YANG YUAN , Zhang Dongying , Zhang Meng , Wang Peihong , Liu Xiaohua , Ge Lina , Lin Wenxuan , Xu Yang , Zhang Yalan , Li Fengjuan , Xu Xujuan , Wu Honghe , Jackson Todd , Ungvari Gabor S , Cheung Teris , Xiang Yutao 
Published: October 2020

Abstract
Background: This study examined the prevalence of depressive symptoms (depression hereafter) and its association with quality of life (QOL) among pregnant and postnatal women in China.Methods: In this multicenter, cross-sectional study, 1,060 pregnant and postnatal women from eight hospitals were assessed. Depression and QOL were measured using standardized instruments.Results: The prevalence of depression was 7.45% (95%CI: 5.87%-9.04%) in the sample. Women with depression had lower QOL in physical, psychological, social and environmental domains compared to those without. Women with physical comorbidities were more likely to suffer from depression (OR=2.391, 95%CI=1.384-4.130, P=0.002).Conclusion: Due to its negative association with QOL, increased attention should be paid to depression in pregnant and postnatal women. Regular screening assessment and preventive measures should be adopted to reduce risk of depression in this population.
Comparable Obesity Parameters with Lung Function in A Chinese Rural Adult Population
Authors: Zeng Xiang , Liu Dongling , An Zhen , Li Huijun , Song Jie , Li Juan , Li Yuchun , Jiang Jing , Li Wen , Gui Lihui , Wu Weidong 
Published: October 2020

Abstract
Background: To assess association between diﬀerent obesity parameters and lung function indicators in a Chinese rural adult population. Methods: A total of 8,284 Chinese adults aged 20 to 80 years old from Xinxiang were recruited in this study. Obesity parameters including BMI, waist circumference (WC), hip circumference (HC), waist hip ratio (WHR), waist height ratio (WHtR), body fat percentage (BFP), basal metabolism (BM), and visceral fat index (VFI) and lung function parameters such as forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were measured according to previous guidance.Results: The total prevalence of obesity defined by BMI, WL, WHR, WHtR, and BFP were 23.2%, 58.2%, 66.7%, 69.2%, and 56.5%. In general, the prevalence of obesity in women was higher than that in men. The average levels of FVC and FEV1 in participants were 3.19 ± 0.72 (L) and 2.68 ± 0.64 (L), respectively. Men have a higher lung function levels than that of women. Lung function levels in obesity group were lower than those in non-obesity group, regardless of gender. Spearman correlation analyses showed that obesity parameters including BMI, WC, HC, WHR, WHtR, BFP, BM, and VFI were significantly correlated with lung function levels such as FVC and FEV1. After adjustment for the potential confounders in further linear regression analyses, BMI, WHtR, BFP, and obesity defined by BMI, WHtR and BFP were negatively associated with lung function, while WC, WHR, and obesity defined by WC and WHR were positively associated with lung function.Conclusions: Taken together, obesity status is closely related to lung function in general Chinese adult population. Weight control and lose is an important strategy to improve of lung function and reduce incidence of respiratory diseases.
CDK1/FBXW7 Facilitates&nbsp;Degradation and Ubiquitination of MLST8 to Inhibit Progression of Renal Cell Carcinoma
Authors: Zhang Encheng , Dong Xiao , Shao Jialiang , Mu Xingyu , Chen Siteng , Wang Yuqi , Zhang Pingzhao , Tan mingyue , Shi Qing , Wang Xiang 
Published: October 2020

Abstract
Background: Recent studies have reported that MLST8 is upregulated in many malignant tumors. Nevertheless, the underlying molecular mechanisms is still unclear. The aim of this work was to investigate how MLST8 contribute to the development and progression of renal cancer (ccRCC).Methods: To identify molecular mediators of the oncogenic tumor function of MLST8, we analyzed a quantitative mass spectrometry by a previous study and checked the amino acid sequence in MLST8. Immunoprecipitation and Western Blotting were used to analyze the interaction between FBXW7 and MLST8. Transwell assays determined cell migration and invasion. In vivo experiments were performed to verify tumor growth. Immunohistochemistry was used to analyze protein levels in patients’ tumor samples. Results: MLST8 is an oncogenic protein in TCGA database and ccRCC clinical specimens. We also ascertain that MLST8 interacts with FBXW7, which was universally regarded as an E3 ubiquitin ligase. MLST8 can be degraded and ubiquitinated by tumor suppressor FBXW7. FBXW7 recognizes a consensus motif (T/S) PXX (S/T/D/E) of MLST8 and triggers MLST8 degradation via the ubiquitin-proteasome pathway. Strikingly, the activated CDK1 kinase engages in the MLST8 phosphorylation required for FBXW7-mediated degradation. In vitro and vivo assay, we further prove that MLST8 is an essential mediator of FBXW7 inactivation-induced tumor growth, migration, and invasion. Furthermore, MLST8 and FBXW7 protein are negatively correlated in human renal cancer specimens. Conclusions: Our findings suggest that MLST8 is a putative oncogene that functions via interaction with FBXW7, and inhibition MLST8 can be a potential future target in ccRCC treatment.
Cervical Cancer Screening Patterns Among HIV-positive Women in Estonia: A Population Based Retrospective Cohort Study
Authors: Tisler Anna , OJAVEE Sven Erik , Veerus Piret , SOODLA Pilleriin , UUSKÜLA Anneli 
Published: October 2020

Abstract
IntroductionThe World Health Organisation (WHO) calls fot the elimination of cervical cancer (CC) as a public health issue. To achieve elimination, efforts must be aligned and accelerated. Women living with HIV (WLWH) have excess risk for developing and dying from CC over the general population. Estimates of cervical cancer screening (CCS) program coverage in Eastern European countries that have experienced HIV epidemics since early 2000s are scarce. MethodsThis population-based retrospective study uses healthcare administrative database and follows cohorts of all WLWH and in a ratio 1:3 randomly matched (age, region) HIV negative women from 2009-2018. Annual and longitudinal (over the whole study period) coverage for CCS (opportunistic, organised, HIV specific) and adjusted odds ratios (AORs) for longitudinal screening coverage predictors were estimated from 2009-2018.ResultsAmong WLWH and HIV negative women, the mean annual coverage with opportunistic screening was 61.45%, and 65.59%; organised screening 20.4%, and 28.7%, respectively (both: p<0.00001). 19.01% (95% CI 18.05-19.97) HIV negative and 13.9% (95% CI 12.35-15.45) WLWH were longitudinally covered with organised CCS. Among WLWH, the mean annual HIV specific CCS coverage was 49.4 % and 24.3% were longitudinally covered. Longitudinal coverage with HIV specific CCS was inversely associated with age, HCV co-infection AOR 0.754 (95% CI 0.619, 0.916), not having insurance AOR 0.331 (95% CI 0.264, 0.412), drug abuse (AOR 0.459, 95%CI 0.336, 0.618) and higher among those retained in HIV care AOR 1.972 (95% CI 1.615, 2.410). Among HIV negative women, longitudinal coverage with organised CCS was inversely associated with residence region and higher among older women. ConclusionsOur results highlight unacceptably low coverage of WLWH with cervical cancer screening in Estonia. There is a need for a dedicated cervical cancer screening efforts for WLWH considering the high cancer risk and rate in the study population.
A gapless, unambiguous metagenome-assembled genome variant of SARS-CoV-2 encoding a rare spike S813I substitution
Authors: Soliman May Sherif , AbdelFattah May , Aman Soad M. N. , Ibrahim Lamyaa M. , Aziz Ramy Karam 
Published: October 2020

Abstract
The novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is causing an unprecedented pandemic, threatening global health, lifestyle, and economy. Genomic surveillance continues to be a critical effort towards tracking and containing the virus. We here report the successful assembly of one single gapless, unambiguous contiguous sequence representing the complete viral genome from a nasopharyngeal swab of an infected healthcare worker in Cairo, Egypt. The genome has all typical features of SARS-CoV-2 genomes, with no protein-disrupting mutations; however, three mutations are worth highlighting and future tracking: a synonymous mutation causing a rare spike S-813-I variation) and two less frequent ones leading to an A41V variation in NSP3, encoded by ORF1a, and a Q677H variation in the spike protein. Both affected proteins, S and NSP3, are relevant to vaccine and drug development.
Program Evaluation of a Student-led Peer Support Service at a Canadian University
Authors: Suresh Rahul , Karkossa Zoe , Richard Jérémie , Karia Maharshee 
Published: October 2020

Abstract
Background: University/college campuses are a rigorous academic environment that also contain numerous financial, social and emotional stressors that often result in the deterioration of students’ mental health. The Peer Support Centre (PSC) is a pilot project that was established to provide peer support to students in these stressful conditions. We wanted to investigate whether peer support is a viable form of support that would benefit university students. The objective of this study is to determine whether the organization was indeed providing a beneficial service to students and if it was fulfilling the needs of the students that visited the service.Methods: After a support session, students (also referred to as supportees) were asked to complete an anonymous questionnaire regarding their self-reported mental wellbeing, their experience with previous professional mental health services, and their experience at the PSC. There weren’t any selection criteria for either the supportees or volunteers as the completion of the questionnaire was completely voluntary. Additionally, volunteers (also referred to as supporters) were asked to complete a similar questionnaire after conducting a support session. With the data collected from 1043 supportees and 797 volunteers from September 2016 – March 2020, a program evaluation was conducted for quality improvement purposes. The responses to the questionnaires were analysed by calculating the means, modes, standard deviations and performing Two-Sample t-tests.Results: The PSC is used by a wide variety of students of different sexes, genders, ethnicities. Students reported having a low ORS score, moderate anxiety as per the GAD-7 and moderate depression according to the PHQ-9. They find it easy to use and rely on it as an alternative form of support when they approach barriers that prevent them from accessing professional services. Lastly, the supporters feel very validated in their role and overall quite prepared and helpful when helping their fellow peers.Conclusions: The established of a service that delivers peer support would be beneficial to the students on a university or college campus as it can serve as a complement to professional services.
Clinical Analysis of Chronic Active EBV Infection with Coronary Artery Dilatation and Matched Case-control Study
Authors: Wei Ang , Ma Honghao , Zhang Liping , Li Zhigang , Guan Yitong , Zhang Qing , Wang Dong , Lian Hongyun , Zhang Rui , Wang Tianyou 
Published: October 2020

Abstract
Objective To investigate the clinical characteristics, treatment, prognosis, and risk factors of chronic active EBV infection (CAEBV) associated with coronary artery dilatation (CAD) in children.Methods Children with CAEBV associated with CAD hospitalized in Beijing Children’s Hospital, Capital Medical University, from March 2016 to December 2019 were analyzed. At the same time, children with CAEBV without CAD were selected as the control group, matched by sex, age, treatment and admission time. The clinical manifestations, laboratory and ultrasonic examinations, treatment and prognosis of the children were collected in both groups.Results There were 10 children with CAEBV combined with CAD, accounting for 8.9% (10/112) of CAEBV patients at the same period, which including 6 males and 4 females, with onset age of 6.05 (2.8-14.3) years. The median follow-up time was 20 (6-48) months. All the patients had high copies of EBV-DNA in whole blood 1.18x107（1.90x105-3.96x107）copies/mL and plasma 1.81x104（1.54x103-1.76x106）copies/mL, and the Epstein-Barr virus encoded small RNA in biopsy was all positive. Among the 10 children, 8 had bilateral CAD, with 2 patients unilateral. After diagnosis, 7 children were treated with L-DEP chemotherapy in our hospital. After chemotherapy, four patients accepted allo-genetic Hematopoietic Stem Cell Transplantation (HSCT). The others were waiting for HSCT. By the end of the follow-up, CAD had returned to normal in 3 patients, and the time from diagnosis of CAD to recovery was 21 (18-68) d. The level of LDH, serum ferritin, TNF-α and IL-10 had statistically significant difference between the two groups (P=0.009, 0.008, 0.026 and 0.030). There were no significant differences in survival rate between the two groups (P=0.416).Conclusion The incidence of CAEBV with CAD was low. CAEBV with CAD did not influence the prognosis. Patients with CAEBV had high LDH, serum ferritin, TNF-α and IL-10 in the early onset were prone to have CAD.
The Impact of Government Debt on Economic Growth in Nigeria
Authors: YUSUF ABDULKARIM , Mohd. Saidatulakmal 
Published: October 2020

Abstract
The study investigated the effect of public debt on Nigeria’s economic growth using annual time series data from 1980-2018. In collecting, evaluating and interpreting secondary data relating to the study objective, the quantitative and ex-post facto research design was adopted. The Autoregressive Distributed Lag method was applied to assess the short and long-term linkages between economic growth and public debt indicators. The empirical results showed that external debt stock constituted an impediment to long-term growth but a short-run growth-enhancement effect. Domestic debt accretion had a noteworthy positive impact on long-term output growth, while its short-term effect was negative. In the long and short-term, debt service payments led to growth retardation, although the amount of foreign reserves greatly improved growth both in the long and short-run. The diagnostic tests results indicated no problems with non-normality, serial correlation, heteroscedasticity and error in the predicted model specification. The findings of this study suggest that concerted efforts should be made to boost domestic revenue generation and execute fiscal transformations that reduce public debt and deficit financing to a sustainable level, while ensuring that borrowed funds are deployed to support growth through productive and self-liquidating investments in principal sectors of the economy.
Quantifying ethnic segregation in cities through random walks
Authors: Sousa Sandro , Nicosia Vincenzo 
Published: October 2020

Abstract
Socioeconomic segregation is considered one of the main factors behind the emergence of large-scale inequalities in urban areas, and its characterisation is an active area of research in urban studies. There are currently many available measures of spatial segregation, but almost all of them either depend in non-trivial ways on the scale and size of the system under study, or mostly neglect the importance of large-scale spatial correlations, or depend on parameters which make it hard to compare different systems on equal grounds. We propose here two non-parametric measures of spatial variance and local spatial diversity, based on the statistical properties of the trajectories of random walks on graphs. We show that these two quantities provide a consistent and intuitive estimation of segregation of synthetic spatial patterns, and we use them to analyse and compare the ethnic segregation of large metropolitan areas in the US and the UK. The results confirm that the spatial variance and local diversity as measured through simple diffusion on graphs provides meaningful insights about the spatial organisation of ethnicities across a city, and allows us to efficiently compare the ethnic segregation of urban areas across the world irrespective of their size, shape, or peculiar microscopic characteristics.
Diversity and Community Structure of Biofilms Found on Stone Momument and Assessment of a Conservation Measure
Authors: Wang Yali , Zhang Huan , Liu Xiaoqing , Song Wei 
Published: October 2020

Abstract
The Leizhou area in the Guangdong province of China is famed for its unique folk art creation, the Leizhou stone dog momument, which is mainly made of basalt. Some of them have a history of more than two thousand years beginning from the Han dynasty. Since the stone dog is mostly seen in the outdoors, such as in fields, many of them have undergone biodeterioration due to lichen and fungi. This study explores measures to prevent biodeterioration and protect stone dogs from degradation. A portable microscope and SEM-EDS were used to observe and identify the micromorphology of the microbiology on the stone, and highthroughput Sequencing technique (Illumina sequencing of gene amplicons) was conducted to analyse the fungi diversity of the biofilm on the stone dogs. The results showed that the dominate fungi were Caloplaca, Trebouxia, Chaetomium, Clitopilus, Acanthostigma, Tolypocladium, Aspergillus, and Toxicocladosporium at the genus level. To control biodeterioration, three kinds of antimicrobials, BYS4002 mix BYB10073, KY-104, and Sino-307, were used for sterilization. After treating the samples for 2 years, BYS4002 mix BYB10073 was found to be the most effective resulting in no trace of lichen on the surface. Sino-307 was also good but revealed traces of lichen on the surface. KY-104 was found to have a very short bacteriostatic effect.
Methodology for the Triage of Urologic Surgical Cases in the Setting of a Pandemic
Authors: Aboumohamed Ahmed , Gottlieb Josh , DeMasi Matthew , Barry Emily , Watts Kara 
Published: October 2020

Abstract
Purpose: The COVID-19 pandemic forced our healthcare system in the Bronx, New York to cancel nearly all surgeries. With the possible second wave approaching, we developed a framework for the prioritization of Urologic surgeries that can be used as a model for those experiencing surges elsewhere. Methods: Each surgeon in the department was asked to rank their cancelled surgeries by priority (Level 1 – least urgent; Level 2 – moderately urgent; Level 3 – most urgent). A committee of urologists assigned a subclass to Level 3 and 2 cases (3a – least urgent; 3b – moderately urgent; 3c – most urgent; 2a – lower priority; 2b – higher priority). The committee then reviewed cases by urgency to arrive on a final priority ranking. Results: A total of 478 total cases were categorized: 250 Level 1, 130 Level 2, 98 Level 3 (73 adult, 25 pediatric). Level 3c involved renal cell carcinoma ≥ T2b, high-grade bladder urothelial carcinoma, adrenal mass/cancer > 6 cm, testicular cancer requiring radical orchiectomy, and penile cancer. Level 3b involved T2a renal masses requiring nephrectomy; high-risk prostate cancer and symptomatic nephrolithiasis were classified as 3a. Level 2 included testicular cancer requiring retroperitoneal lymph node dissection and complicated benign prostatic hyperplasia. Surgeries for urologic reconstruction, erectile dysfunction, and incontinence were considered Level 1.Conclusions: Our disease-specific approach to surgical rescheduling offers appropriate guidance for triaging Urologic surgeries. Our system can provide guidance to other institutions as COVID-19 surges in different regions and with the growing possibility of a second wave.
Ties in Tough Times: How social capital helps lower-income Jewish parents weather the economic hardship of COVID-19
Authors: Horwitz Ilana , Lascar Sasha 
Published: October 2020

Abstract
In this study, we examined how lower-income Jewish households in the Greater Philadelphia area fared in the five months following the start of COVID-19. We interviewed and surveyed 36 parents who self-identified as Jewish, had at least one school-age child, and had a household income of $75K or less. We looked at how social capital helped parents weather the economic hardship brought on by COVID-19. We argue that while bonding social capital could not help people with things like childcare or food preparation, it did help by facilitating linking social capital, which provided low-income parents material resources. While social ties can help parents get by in tough economic times and even weather-related disasters, it turns out the route social capital takes during a pandemic to provide its benefits is importantly different. We conclude by discussing how sheltering-in-place can threaten social capital.