bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration
Authors: Jiang Xingzhi , Ye Zhongxue , Jiang Yafen , Yu Wen , Fang Qian 
Published: October 2020

Abstract
Background
Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of OIP5-AS1 in OC.

Methods
OC tissues and non-tumor tissues (ovary tissues within 3 cm around tumors) were collected from 58 OC patients (age range 36 to 67 years old, mean age 51.4 ± 5.9 years old). The expression of OIP5-AS1 and snail in paired tissues were determined by RT-qPCR. The interaction between OIP5-AS1 and miR-34a was predicted by IntaRNA2.0 and confirmed by dual luciferase reporter assay. The effects of overexpression of OIP5-AS1 and miR-34a on the expression of snail were analyzed by RT-qPCR and Western blotting. Cell invasion and migration were analyzed by Transwell assay.

Results
We observed that the expression of OIP5-AS1 and snail was upregulated and positively correlated with each other in OC. RNA–RNA interaction analysis showed that OIP5-AS1 might sponge miR-34a. In OC cells, overexpression of OIP5-AS1 resulted in the upregulated expression of snail, while overexpression of miR-34a downregulated the expression of snail. In addition, overexpression of miR-34a reduced the effects of overexpression of OIP5-AS1 on the expression of snail. In cell invasion and migration assay, overexpression of OIP5-AS1 and snail resulted in increased OC cell invasion and migration, while overexpression of miR-34a decreased OC cell invasion and migration. Moreover, overexpression of miR-34a attenuated the effects of OIP5-AS1 overexpression on OC cell invasion and migration.

Conclusions
Therefore, OIP5-AS1 may upregulate snail expression in OC by sponging miR-34a to promote OC cell invasion and migration.
A machine learning-based algorithm used to estimate the physiological elongation of ocular axial length in myopic children
Authors: Tang Tao , Yu Zekuan , Xu Qiong , Peng Zisu , Fan Yuzhuo , Wang Kai , Ren Qiushi , Qu Jia , Zhao Mingwei 
Published: October 2020

AbstractBackgroundAxial myopia is the most common type of myopia. However, due to the high incidence of myopia in Chinese children, few studies estimating the physiological elongation of the ocular axial length (AL), which does not cause myopia progression and differs from the non-physiological elongation of AL, have been conducted. The purpose of our study was to construct a machine learning (ML)-based model for estimating the physiological elongation of AL in a sample of Chinese school-aged myopic children.MethodsIn total, 1011 myopic children aged 6 to 18 years participated in this study. Cross-sectional datasets were used to optimize the ML algorithms. The input variables included age, sex, central corneal thickness (CCT), spherical equivalent refractive error (SER), mean K reading (K-mean), and white-to-white corneal diameter (WTW). The output variable was AL. A 5-fold cross-validation scheme was used to randomly divide all data into 5 groups, including 4 groups used as training data and one group used as validation data. Six types of ML algorithms were implemented in our models. The best-performing algorithm was applied to predict AL, and estimates of the physiological elongation of AL were obtained as the partial derivatives ofALpredicted-age curves based on an unchanged SER value with increasing age.ResultsAmong the six algorithms, the robust linear regression model was the best model for predicting AL, with aR2value of 0.87 and relatively minimal averaged errors between the predicted AL and true AL. Based on the partial derivatives of theALpredicted-age curves, the estimated physiological AL elongation varied from 0.010 to 0.116 mm/year in male subjects and 0.003 to 0.110 mm/year in female subjects and was influenced by age, SER and K-mean. According to the model, the physiological elongation of AL linearly decreased with increasing age and was negatively correlated with the SER and the K-mean.ConclusionsThe physiological elongation of the AL is rarely recorded in clinical data in China. In cases of unavailable clinical data, an ML algorithm could provide practitioners a reasonable model that can be used to estimate the physiological elongation of AL, which is especially useful when monitoring myopia progression in orthokeratology lens wearers.
Prevention of post-cardiac surgery vitamin D deficiency in children with congenital heart disease: a pilot feasibility dose evaluation randomized controlled trial
Authors: McNally James Dayre , O’Hearn Katie , Fergusson Dean A. , Lougheed Jane , Doherty Dermot R. , Maharajh Gyaandeo , Weiler Hope , Jones Glenville , Khamessan Ali , Redpath Stephanie , Geier Pavel , McIntyre Lauralyn , Lawson Margaret L. , Girolamo Tara , Menon Kusum ,   on behalf of the Canadian Critical Care Trials Group
Published: October 2020

Abstract
Background
The vast majority of children undergoing cardiac surgery have low vitamin D levels post-operative, which may contribute to greater illness severity and worse clinical outcomes. Prior to the initiation of a large phase III clinical trial focused on clinical outcomes, studies are required to evaluate the feasibility of the study protocol, including whether the proposed dosing regimen can safely prevent post-operative vitamin D deficiency in this high-risk population.

Methods
We conducted a two-arm, double-blind dose evaluation randomized controlled trial in children requiring cardiopulmonary bypass for congenital heart disease. Pre-operatively, participants were randomized to receive cholecalciferol representing usual care (< 1 year = 400 IU/day, > 1 year = 600 IU/day) or a higher dose approximating the Institute of Medicine tolerable upper intake level (< 1 year = 1600 IU/day, > 1 year = 2400 IU/day). The feasibility outcomes were post-operative vitamin D status (primary), vitamin D-related adverse events, accrual rate, study withdrawal rate, blinding, and protocol non-adherence.

Results
Forty-six children were randomized, and five withdrew prior to surgery, leaving 41 children (21 high dose, 20 usual care) in the final analysis. The high dose group had higher 25-hydroxyvitamin D concentrations both intraoperatively (mean difference + 25.9 nmol/L; 95% CI 8.3–43.5) and post-operatively (mean difference + 17.2 nmol/L; 95% CI 5.5–29.0). Fewer participants receiving high-dose supplementation had post-operative serum 25-hydroxyvitamin D concentrations under 50 nmol/L, compared with usual care (RR 0.31, 95% CI 0.11–0.87). Post-operative vitamin D status was associated with the treatment arm and the number of doses received. There were no cases of hypercalcemia, and no significant adverse events related to vitamin D. While only 75% of the target sample size was recruited (limited funding), the consent rate (83%), accrual rate (1.5 per site month), number of withdrawals (11%), and ability to maintain blinding support feasibility of a larger trial.

Conclusions
Pre-operative daily high-dose supplementation improved vitamin D status pre-operatively and at time of pediatric ICU admission. The protocol for a more definitive trial should limit enrollment of children with at least 30 days between randomization and surgery to allow adequate duration of supplementation or consider a loading dose.

Trial registration
ClinicalTrials.gov, NCT01838447. Registered on April 24, 2013
Reverse Water-Gas Shift Reaction via Redox of Re Nanoclusters Supported on TiO2
Authors: Ting Kah Wei , Maeno Zen , Siddiki S M A Hakim , Shimizu Ken-ichi , Toyao Takashi 
Published: October 2020

Abstract
A Re catalyst supported on TiO2 (Re/TiO2) promoted the reverse water-gas shift (RWGS) reaction, exhibiting high selectivity toward CO. Operando X-ray absorption near edge structure (XANES) measurements revealed that the redox of Re species was responsible for promotion of the reaction. The Re/TiO2 catalyst also possessed remarkable durability and maintained &gt;99.9% CO selectivity for more than 1000 h.
Factors predicting timely implementation of radiotherapy innovations: the first model
Authors: Swart Rachelle R , Jacobs Maria JG , Roumen Cheryl , Houben Ruud MA , Koetsveld Folkert , Boersma Liesbeth J 
Published: October 2020

Objective:
The improvement of radiotherapy depends largely on the implementation of innovations, of which effectivity varies widely. The aim of this study is to develop a prediction model for successful innovation implementation in radiotherapy to improve effective management of innovation projects.

Methods:
A literature review was performed to identify success factors for innovation implementation. Subsequently, in two large academic radiotherapy centres in the Netherlands, an inventory was made of all innovation projects executed between 2011 and 2017. Semi-structured interviews were performed to record the presence/absence of the success factors found in the review for each project. Successful implementation was defined as timely implementation, yes/no. Cross-tables, Χ2 tests, t-tests and Benjamin-Hochberg correction were used for analysing the data. A multivariate logistic regression technique was used to build a prediction model.

Results:
From the 163 identified innovation projects, only 54% were successfully implemented. We found 31 success factors in literature of which 14 were significantly related to successful implementation in the innovation projects in our study. The prediction model contained the following determinants: (1) sufficient and competent employees, (2) complexity, (3) understanding/awareness of the project goals and process by employees, (4) feasibility and desirability. The area Under the curve (AUC) of the prediction model was 0.86 (0.8–0.92, 95% CI).

Conclusion:
A prediction model was developed for successful implementation of innovation in radiotherapy.

Advances in knowledge:
This prediction model is the first of its kind and, after external validation, could be widely applicable to predict the timely implementation of radiotherapy innovations.
Hip bone osteonecrosis with intraosseous pneumatosis after abdominal aortic aneurysm repair: a case of emphysematous osteomyelitis
Authors: Chamsi Basha Amjad , Khalifa Mohamed AbdelGhafour , Albadr Fahad , Kaid Jamal , Alsakkaf Hussein 
Published: October 2020

Intraosseous pneumatosis is a rare and often fatal condition characterised by air accumulation in the bone that may be brought about by infection, trauma (surgical or otherwise), degenerative disease or neoplastic processes. Here, we present a case of pelvic emphysematous osteomyelitis following repair of an infected abdominal aortic aneurysm. A 56-year-old Saudi male, known to have diabetes and hypertension, presented to the emergency department complaining of intermittent abdominal pain over the right lower quadrant. The patient was later diagnosed intraoperatively with an infected abdominal aortic aneurysm and treated appropriately. During multiple follow-up imaging studies, the patient was noted to have multiple intra-abdominal fluid collections, as well as intraosseous pneumatosis in the pelvis and right femur. 3 months later, intervention was again required due to patient deterioration and possible aortic graft leakage. Graft abscess was diagnosed and managed. We present a case of an infected abdominal aortic aneurysm that eventually led to emphysematous osteomyelitis of the pelvis. This case report sheds light on intraosseous pneumatosis and emphysematous osteomyelitis, which is characterised by the former, in addition to signs of an underlying infection or abscess formation.
The case for an inclusive scholarly communication infrastructure for social sciences and humanities
Authors: Maryl Maciej , Błaszczyńska Marta , Szulińska Agnieszka , Rams Paweł 
Published: October 2020

This article presents a vision for a scholarly communication research infrastructure for social sciences and humanities (SSH). The COVID-19 pandemic has highlighted the pressing need to access research outputs without the traditional economic and temporal barriers. This article explores the current scholarly communication landscape, assessing the reasons for the slower uptake of open access in SSH research. The authors discuss such frontiers as commercial interests, sources of academic prestige and discipline-specific genres.This article defines and discusses the key areas in which a research infrastructure can play a vital role in making open scholarly communication a reality in SSH: (1) providing a federated and easy access to scattered SSH outputs; (2) supporting publication and dissemination of discipline-specific genres (e.g. monographs, critical editions); (3) providing help with evaluation and quality assurance practices in SSH; (4) enabling scholarly work in national languages, which is significant for local communities; (5) being governed by researchers and for researchers as a crucial factor for productive, useful and accessible services; (6) lastly, considering the needs of other stakeholders involved in scholarly communication, such as publishers, libraries, media, non-profit organisations, and companies.They conclude that a scholarly-driven, inclusive, dedicated infrastructure for the European Research Area is needed in order to advance open science in SSH and to address the issues tackled by SSH researchers at a structural and systemic level.
Small Bowel Obstruction: Clinical Presentation and Surgical Outcomes at Jimma University Medical Centre in Southwest Ethiopia
Authors: Olani Adugna , Lemi Gemechu , Biratu Yonas , Bayana Ebissa 
Published: October 2020

Background The mortality from small bowel obstruction (SBO) range between 2% and 8% globally, and the proper management of it is a clinical challenge for surgeons. In Africa, intestinal obstruction accounts for a great proportion of morbidity, and in Ethiopia it ranges from 20–56%. Aims The aim of this study was to assess the pattern of disease and management outcomes among patient admitted to the surgical ward at Jimma Medical Center in Jimma, Ethiopia. Methods A cross-sectional study was conducted over 5–25 November 2019. Data were entered in Epi-data 3.1 and exported to SPSS v23 for analysis. Logistic regression was undertaken to analyse the association between dependent and independent variables, and P-values below 0.05 at 95% CI were considered indicative of a statistically significant association. Results The study revealed that patient outcomes in SBO were significantly associated with people aged over 60 years, a prolonged hospital stay of more than 14 days, septic shock complications and previous history of congestive heart failure. Conclusions SBO was shown to be an issue of major concern, with major aetiologies related to volvulus, adhesions, intussusception and hernia.
Preprocessing in digital lensless holographic microscopy for intensity reconstructions with enhanced contrast
Authors: Tobon Heberley , Trujillo Carlos , Garcia-Sucerquia Jorge 
Published: October 2020

In this work, a numerical method to enhance the contrast of intensity hologram reconstructions of digital lensless holographic microscopy (DLHM) is presented. The method manipulates the in-line hologram and reference images through mathematical operations between them; additionally, a sharpening operation, functionalized in terms of the parameters of the recording setup, is applied to the said images. The preprocessing of the recorded images produces a modified in-line hologram and a reference wave image from which an intensity reconstruction with a 25% improvement of its contrast, with respect to the conventional reconstruction procedure, is achieved. The method is illustrated with intensity reconstructions of a hologram of a monolayer of polystyrene spheres 1.09 µm in diameter. Finally, the preprocessing method is validated with a modeled hologram, successfully applied to holograms of the section of the head a Drosophila melanogaster fly and its results are contrasted with those obtained via bright-field microscopy.
Populismo em Portugal
Authors: Serrano Estrela 
Published: October 2020

Partidos populistas têm obtido sucesso eleitoral na Europa ultrapassando parti- dos que dominaram o sistema partidário nas últimas décadas. As explicações para o sucesso destes partidos têm-se centrado essencialmente nas desigualdades eco- nómicas entre países, na insegurança e no aumento da imigração e do número de refugiados. A importância do populismo não pode ser hoje ignorada. Em Portugal, o sistema partidário tem-se mantido estável com dois partidos hegemónicos ao centro (Partido Socialista e Partido Social Democrata) alternando entre si no poder, com ou sem coligações com partidos mais pequenos à direita ou com acordos à es- querda, estes últimos na legislatura de 2016-2019. As eleições legislativas de 2019 vieram contudo provocar um “abanão” na estabilidade do sistema com a entrada no Parlamento de três novas formações políticas e o enfraquecimento dos dois parti- dos situados à direita do espectro parlamentar.
Com base nas abordagens conceptuais do populismo este artigo procura mani- festações desse fenómeno no discurso político do líder do novo partido parlamentar Chega, tal como representado na imprensa e na televisão, em três acontecimentos que obtiveram grande mediatização. Concomitantemente, a análise procura perce- ber até que ponto os media podem funcionar como catalisadores ou inibidores de causas e sentimentos populistas. A análise de discurso e a análise de conteúdo são os principais instrumentos de análise utilizados.
Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea
Authors: You Ji Hong , Song Sun Ok , Kang Min Jin , Cho Yoon Young , Kim Sun Wook , Suh Sung Hwan , Lee Sujin , Lee Yong-ho , Lee Byung-Wan 
Published: October 2020

INTRODUCTION:
Clinical studies have produced conflicting results on the effects of metformin on gastrointestinal cancer development. We aimed to investigate the association between metformin use and stomach, colon, liver, and pancreatic cancer development among patients with newly diagnosed, drug-naïve type 2 diabetes.

METHODS:
This retrospective study evaluated propensity score-matched patients with newly diagnosed type 2 diabetes from the Korean National Health Insurance Service database. Metformin users were categorized into tertiles according to the cumulative dose or duration of metformin treatment, and the risks of gastrointestinal cancers were compared.

RESULTS:
Metformin users had reduced risks of developing stomach cancer (hazard ratio [HR]: 0.841, 95% confidence interval [CI]: 0.797–0.887), colon cancer (HR: 0.865, 95% CI: 0.822–0.91), and liver cancer (HR: 0.709, 95% CI: 0.675–0.746; P < 0.001). However, metformin users did not have a reduced overall risk of pancreatic cancer (HR: 1.335, 95% CI: 1.209–1.475; P < 0.001). The risks tended to decrease at higher cumulative doses and durations of metformin use, with significantly reduced risks of all 4 cancers at the highest cumulative dose (≥1,200,000 mg) and the longest duration (≥2,000 days) of metformin use.

DISCUSSION:
This population-based data suggest that metformin could be associated with reductions in the risks of stomach, colon, and liver cancers, as well a reduced risk of pancreatic cancer in some subgroups. Metformin has benefit as a first-line treatment for type 2 diabetes mellitus. A further role in cancer risk reduction could be studied in controlled trials.
EFFECT EXPERIENCE, PROFESSIONAL AUDITOR INDEPENDENCE AND VIGILANCE AGAINST FRAUD DETECTION (Empirical Study On Regional Public Accounting Firm in Central Jakarta)
Authors: Yessie Afly 
Published: October 2020

Abstract

This study aims to examine the effect of the auditor's experience, independence and professional vigilance on fraud detection. This research was conducted on auditors working in the Public Accountant Firm (KAP) of the Central Jakarta area registered with the Indonesian Institute of Certified Public Accountants (Certified) in 2019 using questionnaires. The results indicated resources that the auditor's experience and professional vigilance had a significant effect on fraud detection. While independence does not Significantly influence of fraud detection.
Keywords: Experience, independence, auditor's professional vigilance, fraud detection
A Study on Sustainability of Contemporary Cropping Systems in Bam
Authors: Zarei Fatemeh , Baniasadi Somaye 
Published: October 2020

The study was conducted in Bam in 2019 to develop an index to quantify sustainability of cropping systems in the region. The studied cropping systems included single-cropping systems (palm trees) and multi-cropping systems (citrus, palm trees and alfalfa). The studied indices included economic, social, agricultural indices, as well as, personal features, market access, features of communication, education-extension activities, sustainable agricultural knowledge, attitude towards sustainable agriculture, and obstacles facing sustainable agriculture. The results indicated that the amount of sustainability index was lower than the mean value in 0.56% of the farms and this index was higher than the mean value in 0.44% of the others. Comparison of the mean value of sustainability indices in the studied cropping systems indicated that the mean indices of the type of cropping system, attitude towards sustainable agriculture and extension training activities in multi-cropping systems were more than single crops. The mean indices in social participation and the obstacles facing sustainable agriculture in single cropping systems was more than the multi-cropping ones. Some indices including social participation, sustainable agricultural knowledge and education-extension activities in multivariate regression model remained in the final model as variables that had the largest contribution in the rate of change in the dependent variable (sustainability) and explained = 60% of the changes in the dependent variable. The study showed that the sustainability of multi-cropping systems was more than the single-cropping ones.
Knowledge and Prevention of Farmer Households to the Japanese Encephalitis Infection in Badung Regency, Bali Province, Indonesia
Authors: Ambarawati I Gusti Agung Ayu , Adi Anak Agung Ayu Mirah , Damayanti Putu Ayu Asri , Kardena I Made , Hongo Chiharu 
Published: October 2020

It was reported that 326 Japanese Encephalitis (JE) cases in Indonesia in 2016, majority cases (69.3%) occurred in Bali. It shows that Bali is a prone-area to JE incidence. Previous studies noted that JE is closely related to rural and suburban areas where rice culture and pig farming coexist. This study aims at i) determining knowledge and preventive practices of JE by farmer households; (ii) observing types of mosquitos around farmer households; and (iii) mapping the potency of JE spread using geo-spatial information.
Result from this research shows that farmer households have limited knowledge and preventive actions to the incidence of Japanese encephalitis. Preventive actions carried out by respondents were not for JE incidence as such. Nonetheless, farmer’s response to source of vectors and cleanliness are good preventive actions not just to JE incidence but also for other diseases. In this research, setting up mosquito’s light traps nearby pig pens and rice fields has been successful. The result shows that Culex tritaeniorhynchus was dominant type of mosquito trapped. This is an indication that the selected areas are susceptible to the incidence of JE as the Culex sp was reported as the most competent of JE vector in Asia. Maps of the JE spread in Badung regency also coincidence with the places of Culex sp trapped and the dense of rice field. Based on the limitation of knowledge and preventive actions carried out by farmer households, it is important for the stakeholders in the regency including Regional Health Office and health care workers to socialize the occurrence of JE in the community and how to prevent against the disease.