bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of primary percutaneous cardiac intervention for ST elevation myocardial infarction with a saphenous vein graft culprit
Authors: Kheifets Mark , Vaknin‐Assa Hana , Greenberg Gabriel , Assali Abid , Kornowski Ran , Perl Leor 
Published: December 2019

AbstractBackgroundPatients treated with primary percutaneous coronary intervention (pPCI) for ST elevation myocardial infarction (STEMI) who have a history of coronary artery bypass grafting (CABG) are at high risk of adverse cardiovascular outcomes. Data on the risk of a saphenous vein graft (SVG)—infarct‐related artery (IRA) compared to other culprit vessels are sparse.MethodsThe study was based on a prospectively collected registry of 2,405 consecutive patients with STEMI attending a tertiary medical center in 2001–2017. Patients with an SVG‐IRA (n = 172) were compared with patients with native vessel disease (n = 2,333) for mortality and major adverse cardiac events (MACE), which included death, myocardial infarction (MI), target vessel revascularization (TVR), and coronary artery bypass surgery (CABG) at 1 month and 3 years.ResultsThe SVG‐IRA group was significantly older than the native vessel group (p = .05), with no between‐group differences in rates of male patients (76 vs. 82%, p = .59), diabetes (24.2 vs. 26.2%, p = .73), and renal failure (18.8 vs. 9.2%, p = .25). Mortality was higher in the SVG‐IRA group at 1 month (13.9 vs. 2.5%, p < .01) and 3 years (23.9 vs. 7.4%, p < .01). At 3 years, SVG‐IRA was associated with the highest rates of MACE (55.6%), compared with native vessel disease. After correction for confounders, SVG‐IRA remained an independent risk factor for MACE both at 1 month (HR‐2.08, 95%CI 1.72–3.11, p < .01) and 3 years (HR‐2.01, 95%CI 1.28–3.09, p < .01).ConclusionAmong patients treated with pPCI for STEMI, outcomes are worse when the culprit is an SVG.
Enhanced Catalytic Performance of Zn‐containing HZSM‐5 upon Selective Desilication in Ethane Dehydroaromatization Process
Authors: Goodarzi Farnoosh , Thumbayil Rouzana Pulikkal , Enemark‐Rasmussen Kasper , Mielby Jerrik , Nguyen Thoa T.M. , Beato Pablo , Joensen Finn , Kegnæs Søren 
Published: December 2019

AbstractThe effect of introducing mesoporosity on the catalytic stability and selectivity of Zn‐containing ZSM‐5 catalysts was investigated for direct conversion of ethane to high‐value aromatics. Voids and mesopores were created in the zeolite (Si/Al=40) by selective desilication (recrystallization) using ammonium hydroxide and cetyltrimethylammonium bromide. Zinc was incorporated in the samples by incipient wetness impregnation to achieve different concentrations of 0.5, 1 and 5 wt %. The samples were characterized by XRD, N2 physisorption, TGA, NH3‐TPD, ICP‐OES, FTIR, 1H, 27Al and 29Si solid‐state MAS NMR. The desilicated samples were compared to their parent analogues for ethane conversion to aromatics such as benzene, toluene and xylenes (BTX). All of the desilicated samples showed an improvement in BTX yield and catalytic stability. Thus, the presence of mesoporosity increases the accessibility to the active sites and facilitates the mass transfer of aromatic compounds, which result in higher performance and catalytic stability of the desilicated ZSM‐5 samples containing zinc.
Boosting Microbial Fuel Cell Performance by Combining with an External Supercapacitor: An Electrochemical Study
Authors: Poli Federico , Seri Jacopo , Santoro Carlo , Soavi Francesca 
Published: December 2019

AbstractMicrobial fuel cells (MFCs), despite representing a promising technology, suffer from low power generation that hinders, in most of the cases, their application as power sources. In fact, MFCs are usually coupled with supercapacitors or batteries and these storage units accumulate the energy harvested by MFCs and deliver it on demand. In this work, the electrodes of a MFC are used as electrodes of an internal supercapacitor and discharges and self‐recharges are performed and investigated. Discharges between 1.5 mA and 4 mA were presented producing a maximum power of 1.59 mW. Discharges between 1 mA and 100 mA and recharges are systematically studied for three commercial supercapacitors (SCs) with different capacitances of 1 F, 3 F, and 6 F. The MFC was also connected in parallel with external SCs and discharged galvanostatically. The SC was self‐recharged by the MFC without any additional external power sources. At lower current pulses, the MFC contributed to the overall capacitance, probably owing to its faradaic component. At higher current pulses, the use of SCs enables the energy to be harvested by MFCs at power levels that could not be achieved with the MFC alone. This study demonstrates that, through the proper connection and operation mode of the MFC and SC, it is possible to improve and maximize the performance of every single unit. Understanding the MFC−SC combination is important for identifying the right practical application for which the combination is suitable.
Using chemometrics tools to gain detailed molecular information on chemical processes
Authors: Puxty Graeme , Maeder Marcel 
Published: December 2019

AbstractPaul Gemperline has been active in many areas of data analysis in chemistry. In this contribution, we build on his developments in advanced process analysis. The most prominent aspect is data fusion, the combined analysis of measurements taken on different instruments, using different measurement techniques, and different chemical conditions. We have successfully applied these principles to the investigation of the chemistry of CO2 in aqueous amine solutions.
AuCl3‐Catalyzed Ring‐Closing Carbonyl–Olefin Metathesis
Authors: Wang Rui , Chen Yi , Shu Mao , Zhao Wenwen , Tao Maoling , Du Chao , Fu Xiaoya , Li Ao , Lin Zhihua 
Published: December 2019

AbstractCompared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3‐catalyzed intramolecular ring‐closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional‐group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N‐heterocycle derivatives in good to excellent yields.
Ring‐Opened Hemiporphyrazines: Helical Molecules Exhibiting Circularly Polarized Luminescence
Authors: Tanaka Yusuke , Murayama Tomotaka , Muranaka Atsuya , Imai Eiyu , Uchiyama Masanobu 
Published: December 2019

AbstractWe designed and synthesized a new type of small helical molecule exhibiting intense circularly polarized luminescence (CPL) (12H) by modifying a 20π‐electron hemiporphyrazine with a large transition magnetic dipole moment. The hemiporphyrazine ring was opened and one additional pyridine unit was introduced, resulting in an overlap of two pyridine rings. X‐ray structure analysis confirmed that 12H and its zinc complex (1Zn) adopt a helical geometry. A racemic mixture of 1Zn was resolved into two enantiomers ((P)‐ and (M)‐1Zn), which exhibited CPL with a high luminescence dissymmetry factor (glum) value of ±2.1×10−2. The origin of the large glum value was rationalized by means of DFT calculations. Helical structures could be formed in a diastereoselective manner by covalently attaching chiral units to the skeleton (1’2H and 1’Zn). 1Zn was found to possess chiral recognition ability for amines.
Self‐Assembly of an Amino Acid Derivative into an Antimicrobial Hydrogel Biomaterial
Authors: Garcia Ana M. , Lavendomme Roy , Kralj Slavko , Kurbasic Marina , Bellotto Ottavia , Cringoli Maria C. , Semeraro Sabrina , Bandiera Antonella , De Zorzi Rita , Marchesan Silvia 
Published: December 2019

AbstractN‐(4‐Nitrobenzoyl)‐Phe self‐assembled into a transparent supramolecular hydrogel, which displayed high fibroblast and keratinocyte cell viability. The compound showed a mild antimicrobial activity against E. coli both as a hydrogel and in solution. Single‐crystal XRD data revealed packing details, including protonation of the C‐terminus due to an apparent pKa shift, as confirmed by pH titrations. MicroRaman analysis revealed almost identical features between the gel and crystal states, although more disorder in the former. The hydrogel is thermoreversible and disassembles within a range of temperatures that can be fine‐tuned by experimental conditions, such as gelator concentration. At the minimum gelling concentration of 0.63 wt %, the hydrogel disassembles in a physiological temperature range of 39–42 °C, thus opening the way to its potential use as a biomaterial.
How career plateau beliefs and leader interpersonal unfairness harm job performance in dysfunctional organizational settings
Authors: De Clercq Dirk , Haq Inam Ul , Azeem Muhammad Umer , Hassan Amna 
Published: December 2019

AbstractBuilding on social exchange theory and attribution theory, this study unpacks the relationship between employees' perceptions of organizational politics and job performance, considering the mediating effect of career plateau beliefs and the moderating effect of leader interpersonal unfairness. The findings provide empirical support for the theoretical predictions. An important reason for which perceptions of dysfunctional organizational politics reduce job performance is that employees develop beliefs that opportunities for their career development are limited. This mediating role of career plateau beliefs is particularly salient to the extent that employees are exposed to organizational leaders who treat them with disrespect. Organizations can mitigate the risk that highly politicized decision‐making processes lead to negative performance outcomes by stimulating fair interpersonal relationships.
GPU‐accelerated simulation of polydisperse multiphase flows using dual‐quadrature‐based moment methods
Authors: Santos Fabio P. , Lage Paulo L. C. , Favero Jovani L. , Senocak Inanc 
Published: December 2019

AbstractPolydisperse multiphase flows can be simulated by coupling a population balance model to the multi‐fluid model. For the first time, this simulation is carried out using the dual‐quadrature method of generalized moments (DuQMoGeM) and its direct version to solve the population balance model. The main disadvantage of these methods is the high computational cost of the embedded cubature. Herein, this challenge was addressed by parallelization on graphics processing units, which resulted in a significant acceleration of the simulations, with speedups that can be larger than 1000. Numerical simulations considering simultaneous particles breakage and aggregation were conducted with direct DuQMoGeM‐FC and DQMoM‐FC, whose results were different due to the existence of quadrature error in the latter.
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex‐Biased Phenotypes
Authors: Etheridge Amy S. , Gallins Paul J. , Jima Dereje , Broadaway K. Alaine , Ratain Mark J. , Schuetz Erin , Schadt Eric , Schroder Adrian , Molony Cliona , Zhou Yihui , Mohlke Karen L. , Wright Fred A. , Innocenti Federico 
Published: December 2019

Expression quantitative trait locus (eQTL) studies in human liver are crucial for elucidating how genetic variation influences variability in disease risk and therapeutic outcomes and may help guide strategies to obtain maximal efficacy and safety of clinical interventions. Associations between expression microarray and genome‐wide genotype data from four human liver eQTL studies (n = 1,183) were analyzed. More than 2.3 million cis‐eQTLs for 15,668 genes were identified. When eQTLs were filtered against a list of 1,496 drug response genes, 187,829 cis‐eQTLs for 1,191 genes were identified. Additionally, 1,683 sex‐biased cis‐eQTLs were identified, as well as 49 and 73 cis‐eQTLs that colocalized with genome‐wide association study signals for blood metabolite or lipid levels, respectively. Translational relevance of these results is evidenced by linking DPYD eQTLs to differences in safety of chemotherapy, linking the sex‐biased regulation of PCSK9 expression to anti‐lipid therapy, and identifying the G‐protein coupled receptor GPR180 as a novel drug target for hypertriglyceridemia.
Pharmacokinetic Modeling of Intrathecally Administered Recombinant Human Arylsulfatase A (TAK‐611) in Children With Metachromatic Leukodystrophy
Authors: Troy Steven , Wasilewski Margaret , Beusmans Jack , Godfrey C.J. 
Published: December 2019

Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by deficient arylsulfatase A (ASA) activity, which leads to neuronal sulfatide accumulation and motor and cognitive deterioration. Intrathecal delivery of a recombinant human ASA (TAK‐611, formerly SHP611) is under development as a potential therapy for MLD. We used serum and cerebrospinal fluid (CSF) TAK‐611 concentrations measured during the phase I/II trial of intrathecal TAK‐611 to develop a pharmacokinetic (PK) model describing drug disposition. CSF data were well characterized by a two‐compartment model in the central nervous system (CNS); a single central compartment described the serum data. Estimated parameters suggested rapid distribution of TAK‐611 from CSF into the putative brain tissue compartment, with persistence in the brain between doses (median distributive and terminal half‐lives in the CNS: 1.02 and 477 hours, respectively). This model provides a valuable basis for understanding the PK distribution of TAK‐611 and for PK/pharmacodynamic analyses of functional outcomes.
Fully scheduled decomposition channel estimation based MIMO‐POMA structured LTE
Authors: Kumar V. Madhu , Ramana T. Venkata 
Published: December 2019

SummaryRecent challenging channel estimation for antenna beam shape MIMO without performance loss is to be improved. In this paper, a fully scheduled decomposition‐based channel estimation scheme is proposed by using the concept of MIMO with position‐orthogonal multiple access (POMA) system. Furthermore, to improve power allocation, an iterative power decomposition is proposed by giving solution to power optimization problem. The proposed work channel estimation achieves better comparisons.
Soft tissue tumor diagnosis: A three prong approach utilizing pattern analysis, immunocytochemistry, and molecular diagnostics
Authors: Layfield Lester J. 
Published: December 2019

AbstractTissue diagnosis of a soft tissue neoplasm is of paramount importance for the development of an appropriate treatment plan. Biopsy technique including approach and biopsy method is important to the success of diagnosis and subsequent treatment. Histologic and cytologic diagnoses are difficult and complicated by the large number of soft tissue lesions described, distinctly different biopotential for morphologically similar lesions, often small biopsy specimen size, and the generally limited experience many pathologists have in the diagnosis of soft tissue neoplasms. While utilized less frequently than core‐needle biopsies, fine‐needle aspiration is a valuable initial approach for the classification of soft tissue neoplasms. The combination of pattern based morphologic analysis, immunohistochemistry, and molecular diagnostics represents a utilitarian and generally successful approach for the diagnosis of soft tissue lesions.
The patient presenting with chronic limb‐threatening ischaemia. Does diabetes influence presentation, limb outcomes and survival?
Authors: Fitridge Robert , Pena Guilherme , Mills Joseph L. 
Published: December 2019

AbstractPeripheral arterial disease (PAD) confers an elevated risk of major amputation and delayed wound healing in diabetic patients with foot ulcers. The major international vascular societies recently developed evidence‐based guidelines for the assessment and management of patients with chronic limb‐threatening ischaemia (CLTI). CLTI represents the cohort of diabetic and non‐diabetic patients who have PAD which is of sufficient severity to delay wound healing and increase amputation risk. Diabetic patients with CLTI are more likely to present with tissue loss, infection and have less favourable anatomy for revascularization than those without diabetes. Although diabetes is not consistently reported as a strong independent risk factor for limb loss, major morbidity and mortality in CLTI patients, it is impossible in clinical practice to isolate diabetes from comorbidities, such as end‐stage renal disease and coronary artery disease which occur more commonly in diabetic patients. Treatment of CLTI in the diabetic patient is complex and should involve a multi‐disciplinary team to optimize outcomes. Clinicians should use an integrated approach to management based on patient risk assessment, an assessment of the severity of the foot pathology and a structured anatomical assessment of arterial disease as suggested by the Global Vascular Guidelines for CLTI.
Harvest models of small populations of a large carnivore using Bayesian forecasting
Authors: Andrén Henrik , Hobbs N. Thompson , Aronsson Malin , Brøseth Henrik , Chapron Guillaume , Linnell John D. C. , Odden John , Persson Jens , Nilsen Erlend B. 
Published: December 2019

AbstractHarvesting large carnivores can be a management tool for meeting politically set goals for their desired abundance. However, harvesting carnivores creates its own set of conflicts in both society and among conservation professionals, where one consequence is a need to demonstrate that management is sustainable, evidence‐based, and guided by science. Furthermore, because large carnivores often also have high degrees of legal protection, harvest quotas have to be carefully justified and constantly adjusted to avoid damaging their conservation status. We developed a Bayesian state‐space model to support adaptive management of Eurasian lynx harvesting in Scandinavia. The model uses data from the annual monitoring of lynx abundance and results from long‐term field research on lynx biology, which has provided detailed estimates of key demographic parameters. We used the model to predict the probability that the forecasted population size will be below or above the management objectives when subjected to different harvest quotas. The model presented here informs decision makers about the policy risks of alternative harvest levels. Earlier versions of the model have been available for wildlife managers in both Sweden and Norway to guide lynx harvest quotas and the model predictions showed good agreement with observations. We combined monitoring data with data on vital rates and were able to estimate unobserved additional mortality rates, which are most probably due to poaching. In both countries, the past quota setting strategy suggests that there has been a de facto threshold strategy with increasing proportion, which means that there is no harvest below a certain population size, but above this threshold there is an increasing proportion of the population harvested as the population size increases. The annual assessment of the monitoring results, the use of forecasting models, and a threshold harvest approach to quota setting will all reduce the risk of lynx population sizes moving outside the desired goals. The approach we illustrate could be adapted to other populations of mammals worldwide.
Failure mechanism and fracture aperture characteristics of hard thick main roof based on voussoir beam structure in longwall coal mining
Authors: Zhang Chunwang , Jin Zhixin , Song Xuanmin , Feng Guorui , Li Zhu , Gao Rui , Zhu Defu , Li Chun 
Published: December 2019

AbstractThe mechanism and fracture aperture of thick hard roof failure were theoretically analyzed from the perspective of elastoplastic mechanics. A uniform load cantilever beam was established by considering the voussoir beam structure and stress condition. According to the stress inverse principle in solving the plane strain problem, the internal stress component analytic solution was deduced. Considering the lateral thrust and shear force and by applying the Mohr‐Coulomb failure criterion, the plastic zone boundary equation was obtained. Further analysis of the equivalent stress, equivalent strain, elastic energy density, distortion energy density, and strain energy density was studied with blocks of four different lengths, combined with the rotation angles after failure, to analyze the fissure aperture between straight and curved fracture traces. The theoretical analysis reveals that the deviatoric effect plays the lead role in rupture initiation and propagation; the cracks will deflect during failure, and the fracture trace presents a curved shape. The variation of fracture aperture exhibits a tendency to increase first, then decrease, and then increase along the fracture trace. The analytical approach presented in this paper provides a theoretical basis for determining the main seepage channel flow in underground mining.
A modality‐specific dysfunction of pain processing in schizophrenia
Authors: Zhou Lili , Bi Yanzhi , Liang Meng , Kong Yazhuo , Tu Yiheng , Zhang Xiangyang , Song Yanying , Du Xia , Tan Shuping , Hu Li 
Published: December 2019

AbstractClinical observations showed that schizophrenia (SCZ) patients reported little or no pain under various conditions that are commonly associated with intense painful sensations, leading to a higher risk of morbidity and mortality. However, this phenomenon has received little attention and its underlying neural mechanisms remain unclear. Here, we conducted two experiments combining psychophysics, electroencephalography (EEG), and functional magnetic resonance imaging (fMRI) techniques to investigate neural mechanisms of pain insensitivity in SCZ patients. Specifically, we adopted a stimulus–response paradigm with brief stimuli of different sensory modalities (i.e., nociceptive, non‐nociceptive somatosensory, and auditory) to test whether pain insensitivity in SCZ patients is supra‐modal or modality‐specific, and used EEG and fMRI techniques to clarify its neural mechanisms. We observed that perceived intensities to nociceptive stimuli were significantly smaller in SCZ patients than healthy controls, whereas perceived intensities to non‐nociceptive somatosensory and auditory stimuli were not significantly different. The behavioral results were confirmed by stimulus‐evoked brain responses sampled by EEG and fMRI techniques, thus verifying the modality‐specific nature of the modulation of nociceptive information processing in SCZ patients. Additionally, significant group differences were observed in the spectral power of alpha oscillations in prestimulus EEG and the seed‐based functional connectivity in resting‐state fMRI (seeds: the thalamus and periaqueductal gray that are key nodes in ascending and descending pain pathways respectively), suggesting a possible contribution of cortical–subcortical dysfunction to the phenomenon. Overall, our study provides insight into the neural mechanisms of pain insensitivity in SCZ and highlights a need for systematic assessments of their pain‐related diseases.