bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of permanent stoma creation in patients with mid or low rectal cancer: results of a multicentre cohort study with preoperative evaluation of anal function
Authors: Kim S. , Kim M. H. , Oh J. H. , Jeong S.‐Y. , Park K. J. , Oh H.‐K. , Kim D.‐W. , Kang S.‐B. ,   the Seoul Colorectal Research Group (SECOG)
Published: November 2019

AbstractAimPreoperative factors predictive of permanent stoma creation were investigated in a long‐term follow‐up of patients with mid or low rectal cancer.MethodWe included patients who underwent radical resection for mid or low rectal cancer with available data for preoperative anal function measured by manometry and Faecal Incontinence Severity Index questionnaire between January 2005 and December 2015 in three tertiary referral hospitals. A permanent stoma was defined as a stoma present until the patient’s last follow‐up visit or death. Preoperative factors that predicted permanent stoma creation were analysed.ResultsOver a median follow‐up of 57.4 months (range 12–143 months), a permanent stoma was created in 144/577 (25.0%) patients, including 89 (15.4%) who underwent abdominoperineal resection, one (0.2%) who underwent Hartmann’s operation without reversal, 15 (2.6%) with a diverting ileostomy at the time of initial sphincter‐preserving surgery without undergoing stoma reversal, and 39 (6.8%) who underwent permanent ileostomy formation after sphincter‐preserving surgery. Patients with permanent stoma creation had a shorter tumour distance from the anal verge (P < 0.001), larger tumour size (P = 0.020) and higher preoperative Faecal Incontinence Severity Index score (P = 0.020). On multivariable analysis, tumour distance from the anal verge predicted permanent stoma formation (relative risk 0.53 per centimetre increase; 95% confidence interval 0.46–0.60; P < 0.001) but preoperative anal function did not.ConclusionTumour distance from the anal verge was the only preoperative determinant of permanent stoma creation in rectal cancer patients. These data may help mid and low rectal cancer patients understand the need for permanent stoma.
Monetary reinforcement for self‐monitoring of blood glucose among young people with type 1 diabetes: evaluating effects on psychosocial functioning
Authors: Wong J. J. , Addala A. , Naranjo D. , Hood K. K. , Cengiz E. , Ginley M. K. , Feinn R. S. , Wagner J. A. 
Published: November 2019

AbstractAimsTo explore the auxiliary psychosocial effects of a monetary reinforcement intervention targeting self‐monitoring of blood glucose among young people with Type 1 diabetes.MethodsSixty young people with Type 1 diabetes, HbA1c concentrations between 58 and 119 mmol/mol (7.5–13.0%), and average self‐monitoring of blood glucose <4 times per day were randomized to either enhanced usual care or a 24‐week intervention of monetary rewards for self‐monitoring of blood glucose and associated behaviours (e.g. uploading glucose meters). Data were collected from the young people and their parents at baseline, during the intervention (6, 12 and 24 weeks) and after the intervention (36 weeks).ResultsLinear mixed models were used to evaluate the intervention effects on psychosocial outcomes, adjusting for corresponding baseline levels and potential moderation by baseline level. The intervention reduced diabetes distress at week 6 among young people who had average and high baseline distress. It also reduced diabetes distress at weeks 12 and 24 among those with low baseline distress. The intervention also reduced young person‐reported diabetes‐related family conflict and diabetes‐related interference among those with high baseline scores in these areas; however, the intervention worsened young person‐reported diabetes interference among those with low baseline interference. Effects were medium‐sized and time‐limited.ConclusionsFindings indicate predominantly positive impacts of monetary reinforcement interventions on psychosocial outcomes, although effects varied by outcome and time point. Whereas early improvements in diabetes distress were observed for all who received the intervention, improvements in other areas varied according to the level of psychosocial challenge at baseline. Incorporating psychosocial interventions may bolster and maintain effects over time.
Interrelated Pathogenesis? Neuronal Intranuclear Inclusion Disease Combining With Hemiplegic Migraine
Authors: Wang Rongfei , Nie Xiting , Xu Shiyang , Zhang Mingjie , Dong Zhao , Yu Shengyuan 
Published: November 2019

BackgroundNeuronal intranuclear inclusion disease (NIID) is considered a heterogeneous disease because of its highly variable clinical manifestations. To date, there are no reports of NIID patients presenting with hemiplegic migraine (HM)‐like headache, or of HM and NIID co‐occurring as comorbidity, and the connection between these 2 seemingly unrelated clinical conditions has yet to be established.MethodWe present a patient with NIID who was previously diagnosed with HM. To determine the pathogenesis of HM in this NIID patient, we systematically reviewed published NIID and HM cases and cataloged them based on their clinical manifestations.ResultThe clinical manifestations of NIID is highly various; however, there is no case reported to date that shows HM‐like symptoms or cerebral edema. All documented symptomatic HM cases show vascular dysfunction to various degrees, but none of them has been shown to be correlated with NIID.ConclusionOur patient is the first documented case in which HM and NIID occur simultaneously. Vascular dysfunctions that cause cerebral hypoperfusion and glucose hypometabolism, two of the dominant causes of symptomatic HM, may be associated with the accumulation of eosinophilic hyaline inclusions that cause NIID. However, the existence of inclusions may also alter neuronal behavior and indirectly cause cerebral hypoperfusion and glucose hypometabolism. Further research and observations are needed to examine the relationship between HM and NIID.
Less nephrotoxicity of paclitaxel and ifosfamide plus nedaplatin for refractory or relapsed germ cell tumors in patients with impaired renal function
Authors: Shiraishi Takumi , Nakamura Terukazu , Takamura Toshiya , Oishi Masakatsu , Yamada Takeshi , Yamada Yasuhiro , Ueda Takashi , Fujihara Atsuko , Hongo Fumiya , Okihara Koji , Ukimura Osamu 
Published: November 2019

ObjectivesTo determine the safety and efficacy of the combined regimen of paclitaxel and ifosfamide plus nedaplatin for patients with refractory or relapsed germ cell tumors and impaired renal function.MethodsOf a total of 68 patients who received paclitaxel, ifosfamide and nedaplatin chemotherapy for germ cell tumors, those with an estimated glomerular filtration rate <60 mL/min/1.73 m2 before paclitaxel, ifosfamide and nedaplatin treatment were defined as having renal dysfunction. The combination chemotherapy regimen included paclitaxel (210 mg/m2 on day 1) and ifosfamide (1.2 g/m2 on days 2–6) with nedaplatin (100 mg/m2 on day 2) on a 3‐week cycle.ResultsA total of 10 patients had renal dysfunction with a median estimated glomerular filtration rate of 49.97 mg/mL/1.73 m2 (range 31.7–57.5 mg/mL/1.73 m2). Paclitaxel, ifosfamide and nedaplatin chemotherapy was given as second‐line therapy in four patients, third‐line in four and fourth‐line or later in two. Patients with impaired renal function received pretreatment of a median of 5.5 cycles of platinum‐based chemotherapy (range 3–11 cycles) with a median cisplatin dose of 550 mg/m2. The patients were given two to six cycles of paclitaxel, ifosfamide and nedaplatin chemotherapy with no dose reduction, with an overall response rate of 60%. Chemotherapy‐induced kidney dysfunction was not observed in any patient with decreased renal function. Furthermore, there was no difference in the frequency of adverse events between patients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) and those with normal renal function (estimated glomerular filtration rate ≥60 mL/min/1.73 m2).ConclusionsPaclitaxel, ifosfamide and nedaplatin chemotherapy can be considered a safe and effective regimen that results in less nephrotoxicity in germ cell tumor patients with renal dysfunction.
What Does the Development of Fresh Expressions of Church in the UK Tell Us about Mission Today?
Authors: Male David , Weston Paul 
Published: November 2019

AbstractThis article explores the significance of the Fresh Expressions movement in the UK since the ground‐breaking Mission‐Shaped Church report was published by the Church of England in 2004. After reviewing the background to this report, the article explores some of the report's central themes and examines some of the more recent research on the movement's impact in the UK. It then highlights six ways in which fresh expressions continue to be significant as a missionary response in a post‐Christian context. These include the movement's theological underpinnings, its reassessment of key questions in ecclesiology, its commitment to local and contextual mission, and the emergence of a predominantly lay leadership. In recognizing that the movement is still in a state of evolution, the article concludes by suggesting some areas of continuing debate and challenge for the future.
Learning about Spirituality Together with “Seekers”
Authors: Bargár Pavol 
Published: November 2019

AbstractThe present era, often referred to as post‐secular, has in many places seen a resurgence in spirituality. Nevertheless, the contemporary quest for spirituality is unique in the sense that many people do not expect to have their spiritual needs fulfilled within the structures of organized religion, starting on a journey of their own explorations instead. Sociologists of religion, therefore, tend to employ the “dwellers” and “seekers” paradigm to account for this phenomenon. This paper will explore this phenomenon in the context of the Czech Republic, whose citizens are frequently characterized as distrustful toward institutional religiosity, through the lens of the recent World Council of Churches' affirmation on mission and evangelism, Together towards Life: Mission and Evangelism in Changing Landscapes (TTL). For our purpose, the statement's emphasis on both “transformative spirituality” and “mission from the margins” will be of central importance. Using the notion of transformative spirituality as the energy engendered by the Spirit for the transformation of life and creation, it will be suggested that “seekers” can be agents in God's mission of liberation, reconciliation, and transformation, despite their inability or unwillingness to identify themselves with the church as institution. Keeping in mind ethical considerations, the paper will not seek to make a case for a forced “christening” of the seekers. Rather, it will argue that they can become partners in missio Dei, thus giving the notion of “mission from the margins” a new, contextually relevant dimension.
Trinitarian Mission and Practical Theology
Authors: Macallan Brian 
Published: November 2019

AbstractThe contextual dimension of mission remains both critical and relevant in understanding the nature and scope of the church with regard to its place and purpose. This is formed against the backdrop of the continual importance of the missio Dei in framing its engagement. Newbigin's conception of trinitarian mission is one approach that can give specific focus to this understanding. A trinitarian missional ecclesiology can find common ground with practical theology in service of mission. Practical theology should be understood contextually and can be conceived missiologically. By bringing Newbigin's trinitarian mission into conversation with practical theology, an important conversation is generated regarding the contextual nature of both the discipline of practical theology and the missio Dei.
Identification of novel influenza A virus exposures by an improved high‐throughput multiplex MAGPIX platform and serum adsorption
Authors: Li Zhu‐Nan , Cheng Emily , Poirot Eugenie , Weber Kimberly M. , Carney Paul , Chang Jessie , Liu Feng , Gross F. Liaini , Holiday Crystal , Fry Alicia , Stevens James , Tumpey Terrence , Levine Min Z. 
Published: November 2019

AbstractBackgroundThe development of serologic assays that can rapidly assess human exposure to novel influenza viruses remains a public health need. Previously, we developed an 11‐plex magnetic fluorescence microsphere immunoassay (MAGPIX) by using globular head domain recombinant hemagglutinins (rHAs) with serum adsorption using two ectodomain rHAs.MethodsWe compared sera collected from two cohorts with novel influenza exposures: animal shelter staff during an A(H7N2) outbreak in New York City in 2016‐2017 (n = 119 single sera) and poultry workers from a live bird market in Bangladesh in 2012‐2014 (n = 29 pairs). Sera were analyzed by microneutralization (MN) assay and a 20‐plex MAGPIX assay with rHAs from 19 influenza strains (11 subtypes) combined with serum adsorption using 8 rHAs from A(H1N1) and A(H3N2) viruses. Antibody responses were analyzed to determine the novel influenza virus exposure.ResultsAmong persons with novel influenza virus exposures, the median fluorescence intensity (MFI) against the novel rHA from exposed influenza virus had the highest correlation with MN titers to the same viruses and could be confirmed by removal of cross‐reactivity from seasonal H1/H3 rHAs following serum adsorption. Interestingly, in persons with exposures to novel influenza viruses, age and MFIs against exposed novel HA were negatively correlated, whereas in persons without exposure to novel influenza viruses, age and MFI against novel HAs were positively correlated.ConclusionsThis 20‐plex high‐throughput assay with serum adsorption will be a useful tool to detect novel influenza virus infections during influenza outbreak investigations and surveillance, especially when well‐paired serum samples are not available.
Selecting the hologenome to breed for an improved feed efficiency in pigs—A novel selection index
Authors: Weishaar Ramona , Wellmann Robin , Camarinha‐Silva Amelia , Rodehutscord Markus , Bennewitz Jörn 
Published: November 2019

AbstractMost traits in animal breeding, including feed efficiency traits in pigs, are affected by many genes with small effect and have a moderately high heritability between 0.1 and 0.5, which enables efficient selection. Since the microbiota composition in the gastrointestinal tract is also partly heritable and was shown to have a substantial effect on feed efficiency, the host genes affect the phenotype not only directly by altering metabolic pathways, but also indirectly by changing the microbiota composition. The effect of the microbiota composition on the breeding value of an animal is the conditional expectation of its breeding value, given the vector with microbiota frequencies, that is The breeding value of an animal can therefore be decomposed into a heritable contribution that arises from an altered microbiota composition and a heritable contribution that arises from altered metabolic pathways within the animal, so Instead of selecting for breeding value , an index comprising the two components and with appropriate weights, that is , can be used. The present study shows how this breeding strategy can be applied in pig genomic selection breeding scheme for two feed efficiency traits and daily gain.
Assessing the effectiveness of a pharmaceutical care service on the quality of life of women with polycystic ovarian syndrome living in war and non‐war countries
Authors: Alkoudsi Kinda T. , Al‐Qudah Raja'a , Basheti Iman A. 
Published: November 2019

AbstractRationale, aims, and objectivesPolycystic ovarian syndrome (PCOS) is a serious health problem that affects women of all ages worldwide, including their quality of life (QOL). Interventions on lifestyle modification can be a suitable therapy. This study aimed to evaluate the effect of a PCOS pharmaceutical care service on QOL for women diagnosed with PCOS living in Syria (a country affected by war) and Jordan (non–war‐zone country).MethodsPCOS women from both Syria and Jordan with age above 16 years were recruited in the study. Women randomly allocated into active group received an educational intervention by the pharmacist (via oral and written educational module) with special focus on diet and exercise. Women allocated to the control group did not receive the educational intervention. Both groups were followed for 4 months. Women in both groups completed the QOL questionnaire at both baseline and end of study. Multiple‐regression analysis was performed to identify factors associated with change in QOL scores across the study.ResultsPCOS women (n = 118) from both Syria (n = 60) and Jordan (n = 58) were recruited. Unlike control group patients, QOL was significantly improved in the active group at the end of the study for Syrian (102.75 vs 118.50, P < 0.001) and Jordanian women (95.31 vs 112.67, P < 0.001). Study group (active versus control) and difference in anxiety scores across the study were the only independent variables that showed association with the dependent variable, difference in QOL mean scores across the study period.ConclusionA pharmacist led intervention on lifestyle modification delivered to PCOS women led to positive effects on QOL scores. The intervention was successful in Syria and Jordan. This highlights the significant role that pharmacists can play in improving the life of women with PCOS whether living in war or non–war‐zone countries.
Dietary supplementation of potassium sorbate, hydrated sodium calcium almuniosilicate and methionine enhances growth, antioxidant status and immunity in growing rabbits exposed to aflatoxin B1 in the diet
Authors: Reda Fayiz M. , Ismail Ismail E. , El‐Mekkawy Mohamed M. , Farag Mayada R. , Mahmoud Hemat K. , Alagawany Mahmoud 
Published: November 2019

AbstractThe present experiment was conducted to evaluate the effect of dietary supplementation with some feed additives (potassium sorbate; Sor, hydrated sodium calcium almuniosilicate; Hsc and L‐methionine; L‐M) against aflatoxin B1 (AF) toxicity in rabbits. A total of 72 growing rabbits (5‐week‐old) were distributed into six equal groups (4 replicates with 3 rabbits each). The experimental groups are as follows: control group, AF group (supplemented with AF 0.3 mg/kg diet), AF + Sor group (AF 0.3 mg/kg diet + Sor 2 g/kg diet), AF + Hsc group (AF 0.3 mg/kg diet + Hsc 5 g/kg diet), AF + L‐M group (AF 0.3 mg/kg diet + L‐M 8 g/kg diet) and AF + Mix group (AF 0.3 mg/kg diet + 2 Sor + 5 Hsc + 8 L‐M g/kg diet). Live body weight and weight gain at 13 weeks of age were significantly reduced by AF. Feed intake at 13 weeks of age was decreased in AF, AF + Hsc and AF + Mix compared to the control. AF, AF + Hsc and AF + Mix showed the lowest total antioxidant capacity compared to the control. The highest level of reactive oxygen species and 8‐Hydroxy‐2‐desoxyguanosine was observed in AF group. Using of other supplements with AF increased immunoglobulinM than AF alone. In conclusion, dietary supplementation of Sor, L‐M, Hsc or their mixture was effective in reducing the adverse effects of AF on performance, antioxidant and immune status of rabbits with more better improvement obtained by Sor or L‐M separately.
Heritability and genetic correlations for infectious hypodermal and hematopoietic necrosis virus load, body weight at harvest, and survival rate in Pacific white shrimp (Litopenaeus vannamei)
Authors: Hernández‐Ruíz Hortencia , Montaldo Hugo H. , Bustos‐Martínez Jaime , Campos‐Montes Gabriel R. , Castillo‐Juárez Héctor 
Published: November 2019

AbstractHeritability and genetic correlations for body weight at harvest size (BW), grow‐out survival (SU), and log‐transformed infectious hypodermal and hematopoietic necrosis virus (IHHNV) load (VLln) in Litopenaeus vannamei were estimated. Data were obtained in 2012 from a shrimp breeding population in Mexico using 12,440 shrimp for BW and 16,814 shrimp for SU, and quantitative polymerase chain reaction determinations from 160 full‐sib families were obtained for VLln. DNA was extracted from pooled muscle samples of six shrimp per family for a total of 960 individuals. Heritability estimates for BW, SU, and VLln at the family mean and at individual levels were 0.24 ± 0.08, 0.02 ± 0.01, 0.42 ± 0.45, and 0.08 ± 0.11, respectively. Genetic correlation estimates of BW with SU, BW with VLln, and VLln with SU were 0.40, −0.04, and −0.57, respectively. Our results suggest that VLln has genetic variation and a favorable genetic association with BW and SU. No serious drawbacks were found from selection responses estimated using single‐trait and multitrait indices to increase BW and SU and decrease VLln. Favorable correlated responses for IHHNV tolerance estimated as BW/VLln and SU/VLln were also found. This study offers new insights into the possibility of using IHHNV viral load as a possible selection criterion in L. vannamei breeding programs.
The transcription factor Zt107320 affects the dimorphic switch, growth and virulence of the fungal wheat pathogen Zymoseptoria tritici
Authors: Habig Michael , Bahena‐Garrido Sharon Marie , Barkmann Friederike , Haueisen Janine , Stukenbrock Eva Holtgrewe 
Published: November 2019

SummaryZymoseptoria tritici is a filamentous fungus causing Septoria tritici blotch in wheat. The pathogen has a narrow host range and infections of grasses other than susceptible wheat are blocked early after stomatal penetration. During these abortive infections, the fungus shows a markedly different gene expression pattern. However, the underlying mechanisms causing differential gene expression during host and non‐host interactions are largely unknown, but likely include transcriptional regulators responsible for the onset of an infection programme in compatible hosts. MoCOD1, a member of the fungal Zn(II)2Cys6 transcription factor family, has been shown to directly affect pathogenicity in the rice blast pathogen Magnaporthe oryzae. Here, we analyse the role of the putative transcription factor Zt107320, a homologue of MoCOD1, during infection of compatible and incompatible hosts by Z. tritici. We show for the first time that Zt107320 is differentially expressed in host versus non‐host infections and that lower expression corresponds to an incompatible infection of non‐hosts. Applying reverse genetics approaches, we further show that Zt107320 regulates the dimorphic switch as well as the growth rate of Z. tritici and affects fungal cell wall composition in vitro. Moreover, ∆Zt107320 mutants showed reduced virulence during compatible infections of wheat. We conclude that Zt107320 directly influences pathogen fitness and propose that Zt107320 is involved in the regulation of growth processes and pathogenicity during infection.