bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mathematical framework on Cattaneo–Christov model over an incessant moving needle
Authors: Reddy M. Gnaneswara , Vijaya Kumari P. , Upender Reddy G. , Ganesh Kumar K. , Prasannakumara B. C. 
Published: June 2020

PurposeThe main theme of this paper is the effect of viscous dissipation Darcy–Forchheimer flow and heat transfer augmentation of a viscoelastic fluid over an incessant moving needle.Design/methodology/approachThe governing partial differential equations of the current problem are diminished into a set of ordinary differential equations using requisite similarity transformations. Energy equation is extended by using Cattaneo–Christov heat flux model with variable thermal conductivity. By applying boundary layer approximation system of equations is framed.FindingsConvective condition is also introduced in this analysis. Obtained set of similarity equations are then solved with the help of efficient numerical method four–fifth-order RKF-45.Originality/valueThe outcomes of various pertinent parameters on the velocity, temperature distributions are analysed by using portraits.
Business networking and internationalization: testing the mediation role of organizational learning
Authors: Sendawula Kasimu , Ngoma Muhammed , Bananuka Juma , Kimuli Saadat Nakyejwe Lubowa , Kabuye Frank 
Published: June 2020

PurposeThe purpose of this study was to establish the mediation role of organizational learning in the relationship between business networking and internationalization of manufacturing small and medium-sized enterprises (SMEs) using evidence from Uganda.Design/methodology/approachThis study is cross sectional and correlational. Data were collected through a questionnaire survey of 96 manufacturing SMEs. Data were analyzed through correlation coefficients, hierarchical regression and mediation analysis using Statistical Package for the Social Sciences and MedGraph - Excel Version.FindingsFindings indicate that organizational learning partially mediates the relationship between business networking and internationalization of SMEs. Results further reveal that business networking and organizational learning significantly predict internationalization of SMEs.Originality/valueThis study contributes to the already existing literature on internationalization of SMEs as it provides initial empirical evidence on the mediating role of organizational learning in the relationship between business networking and internationalization of SMEs using evidence from a developing country – Uganda.
Phosphatase‐associated protein MoTip41 interacts with the phosphatase MoPpe1 to mediate crosstalk between TOR and cell wall integrity signalling during infection by the rice blast fungus Magnaporthe oryzae
Authors: Qian Bin , Liu Xinyu , Ye Ziyuan , Zhou Qikun , Liu Peng , Yin Ziyi , Wang Wenhao , Zheng Xiaobo , Zhang Haifeng , Zhang Zhengguang 
Published: June 2020

SummaryThe type 2A (PP2A) and type 2A‐like (PP4 and PP6) serine/threonine phosphatases participate in a variety of cellular processes, such as cell cycle progression, signal transduction and apoptosis. Previously, we reported that the PP6 catalytic subunit MoPpe1, which interacts with and is suppressed by type 2A associated protein of 42 kDa (MoTap42), an essential protein involved in the target of rapamycin (TOR) signalling pathway, has important roles in development, virulence and activation of the cell wall integrity (CWI) pathway in the rice blast fungus Magnaporthe oryzae. Here, we show that Tap42‐interacting protein 41 (MoTip41) mediates crosstalk between the TOR and CWI signalling pathways; and participates in the TOR pathway via interaction with MoPpe1, but not MoTap42. The deletion of MoTIP41 resulted in disruption of CWI signalling, autophagy, vegetative growth, appressorium function and plant infection, as well as increased sensitivity to rapamycin. Further investigation revealed that MoTip41 modulates activation of the CWI pathway in response to infection by interfering with the interaction between MoTap42 and MoPpe1. These findings enhance our understanding of how crosstalk between TOR and CWI signalling modulates the development and pathogenicity of M. oryzae.
Introduction: Swift's Queerness
Authors: Kavanagh Declan , Klein Ula Lukszo 
Published: June 2020

AbstractIn raising the topic of Jonathan Swift and queerness, we might just as plausibly ask: what is not queer about Swift? From the strangely erotic spectacle of libidinous Yahoos in Gulliver's Travels (1726) to his gruesome suggestion to cannibalise Irish children in A Modest Proposal (1729), Swift's satire singularly bristles with queer potential. The six articles in this supplement variously offer queer theoretical and pedagogical engagements with Swift's work, while also, importantly, foregrounding how Swift's writing was queer and queering in its own time. This introduction presents a brief case study in queering Swift before surveying the articles that feature in this 'Queer Swift' supplement.
Cybersecurity Disclosure by the Companies on the S&P/TSX 60 Index
Authors: Héroux Sylvie , Fortin Anne 
Published: June 2020

ABSTRACTCybersecurity has become a topic of great interest since 2010. Accounting issues surrounding cybersecurity governance, management, and disclosure have gained attention from accounting standard setters, large accounting firms, and professional associations, but only a limited number of studies have looked at cybersecurity disclosure. In this study, we examine whether the content of cybersecurity disclosures of Canadian firms comprising the S&P/TSX 60 index is aligned with best practices—that is, financial regulators' guidelines in that matter. A content analysis was performed of documents issued between January 2017 and mid‐2018, consisting of recent annual information forms (AIFs), annual and quarterly management's discussion and analysis (MD&As), proxy circulars, material change reports, and news releases. To assess the nature and extent of cybersecurity disclosure, we developed a scoring grid featuring 40 items based on financial regulators' guidelines. Results show that cybersecurity disclosure levels are low. Companies vary widely in the amount of detail they provide, and the information is often not company‐specific. The variations among industrial sectors involve the categories related to cybersecurity risk, cybersecurity risk mitigation, and other items. Most of the companies provided cybersecurity disclosures in the annual MD&A, and several reiterated some disclosure items in the AIF and proxy circular. The results of this study highlight some areas where cybersecurity disclosures have evolved and others where they could be improved. They suggest that some firms strive to avoid boilerplate language and be more company‐specific. The findings also suggest that financial regulators could issue more stringent requirements.
Overconfidence and Resistance to Abandoning Unprofitable Capital Budgeting Projects: The Effects of Autonomy, Internal Audit, and Accountability
Authors: Jermias Johnny , Hoi Hu Billy Kin 
Published: June 2020

ABSTRACTThe purpose of this study is to investigate the effects of managers' autonomy in choosing a capital budgeting project has on their confidence in managing the project. Furthermore, this study examines the role that internal audit reports and accountability play in mitigating the impact of autonomy on managers' resistance to abandoning unprofitable capital budgeting projects. Building on motivated reasoning theory, we hypothesize and find that managers who are given autonomy to choose their own projects are more confident that their projects will be successful than managers who are assigned the projects by their superiors. This study also shows that internal audit reports and accountability are effective mechanisms for reducing the influence of prior decisions on managers' resistance to abandoning unprofitable projects.
baRcodeR: An open‐source R package for sample labelling
Authors: Wu Yihan , Lougheed David R. , Lougheed Stephen C. , Moniz Kristy , Walker Virginia K. , Colautti Robert I. 
Published: June 2020

Abstract

Repeatable experiments with accurate data collection and reproducible analyses are fundamental to the scientific method but may be difficult to achieve in practice. Open‐source tools aid the reproducibility of data analysis, but analogous tools are generally lacking for sample collection and other early stages of scientific inquiry.

We introduce the R package baRcodeR for generating informative identifier (ID) codes with digitally encoded linear or 2D barcodes. Codes can be imported from an existing dataset (e.g. CSV file) or generated rapidly in baRcodeR, producing scannable barcodes with customizable page layouts for printing and scanning with consumer‐grade printers and scanners.

User‐defined ID codes may contain a simple sequence (e.g. SAMPLE‐0427) or encode more meaningful sample information such as individual subjects, treatment groups, sample populations, time points, spatial coordinates, subsamples or other associations (e.g. Pop22‐Ind08‐Time40). In addition to command‐line functions, a graphical‐user‐interface (GUI) is available from the ‘Addins’ menu of R Studio or online at https://bit.ly/baRcodeR to assist with ID code and barcode label creation.

baRcodeR can help biologists apply principles of open and reproducible science to collect and manage biological samples.
Risk of psychiatric diagnoses in children and adolescents of parents with torture trauma and war trauma
Authors: Bager L. , Agerbo E. , Skipper N. , Høgh Thøgersen M. , Laursen Thomas Munk 
Published: June 2020

ObjectiveEvidence point to intergenerational effects of trauma in refugee populations. This study estimates the risk of psychiatric diagnoses in children of severely traumatized refugees. The unique clinical sample consisted of refugee parents treated for torture trauma and war trauma, and outcomes were investigated using population‐level data.MethodA nationwide register study, following all children residing in Denmark. The exposure was parental torture trauma and war trauma, and outcomes were any psychiatric disorder, mood, neurotic, behavioural and emotional disorders and disorders of psychological development. Children’s hazard of being diagnosed was estimated using Cox proportional hazards regression. Study participants were followed from the date of birth or immigration to their 18th birthday.ResultsThe cohort included 3 346 993 children of which 19 294 were identified as offspring to traumatized refugees. During the study period, 205 610 children were diagnosed with a psychiatric disorder. Children with parents from the Middle East and Northern Africa had a hazard ratio of 0.78 (95% CI: 0.72, 0.84) for those treated for parental trauma and 0.79 (95% CI: 0.76, 0.81) for those not treated compared with children of non‐traumatized Danish‐born parents. For children of parents from former Yugoslavia, the corresponding estimates were 0.69 (95% CI: 0.58, 0.81) and 0.69 (95% CI: 0.65, 0.73).ConclusionThe results suggest that children of parents with and without registered torture trauma and war trauma have a lower risk of being diagnosed with a psychiatric disorder compared to children of Danish‐born parents. These findings contradict research done on the transmission of trauma but supports evidence suggesting mental health services underutilization by refugee and ethnic minority populations.
Effect of intra‐operative intravenous lidocaine on opioid consumption after bariatric surgery: a prospective, randomised, blinded, placebo‐controlled study
Authors: Plass F. , Nicolle C. , Zamparini M. , Al Issa G. , Fiant A. L. , Le Roux Y. , Gérard J. L. , Fischer M. O. , Alvès A. , Hanouz J.‐L. 
Published: June 2020

SummaryPeri‐operative lidocaine infusion warrants investigation in bariatric surgery because obese patients present different physiological and pharmacological risks. This single‐centre, prospective, randomised double‐blind placebo‐controlled study enrolled obese patients scheduled for laparoscopic bariatric surgery using an enhanced recovery protocol. Patients received either lidocaine (bolus of 1.5 mg.kg−1, then a continuous infusion of 2 mg.kg−1.h−1 until the end of the surgery, then 1 mg.kg−1.h−1 for 1 h in the recovery area) or identical volumes and rates of 0.9% saline. The primary outcome was the consumption of the equivalent of oxycodone consumption over the first 3 postoperative days. Secondary outcomes were: postoperative pain; incidence of nausea and vomiting; bowel function recovery; and lengths of stay in the recovery area and in hospital. Plasma concentrations of lidocaine were measured. On the 178 patients recruited, data were analysed from 176. The median (IQR [range]) equivalent intravenous oxycodone consumption was 3.3 mg (0.0–6.0 [0.0–14.5]) and 5.0 mg (3.3–7.0 [3.3–20.0]) in the lidocaine and saline groups, respectively (difference between medians (95%CI): 1.7 (0.6–3.4) mg; p = 0.004). Length of stay in the recovery area, postoperative pain, nausea and vomiting, day of recovery of bowel function, and length of stay in hospital were not different between groups. Mean (SD) lidocaine plasma concentrations were 2.44 (0.70) µg.ml−1 and 1.77 (0.51) µg.ml−1 at the end of surgery and 1 hour after the end of infusion, respectively. Lidocaine infusion during bariatric surgery resulted in a clinically non‐relevant difference in postoperative oxycodone consumption.
Design and establishment of a cancer registry: a literature review
Authors: Wormald Jamie S. , Oberai Tarandeep , Branford‐White Harriet , Johnson Luke J. 
Published: June 2020

SummaryBackgroundEstablishment of a cancer registry is a complex process that requires substantial resources and careful planning. There are numerous resources available to provide guidance for this, which include guidelines and frameworks of varying quality. It is the authors' goal to identify evidence‐based recommendations within the literature to help guide the process of designing a new registry with optimal efficiency, workability and data use. The objective of this study is to examine the primary literature for evidence‐based recommendations on how to design and establish a cancer registry, with a focus on literature which analyses the performance and usefulness of already established registries or guidelines.MethodsAn electronic search was completed in MEDLINE, CINAHL, EMCARE, SCOPUS and the Cochrane Database of Systematic Reviews. Recommendations were extracted from the identified articles and collated as themes.ResultsNine articles of varying quality were included in the review. Recommendations obtained from the literature included broad themes of the importance of clinician involvement, establishment of clear data definitions, number of variables used, inbuilt strategies to improve quality and completeness of data, considerations of costs, an ‘opt‐out’ strategy for ethics and privacy and flexibility of the system.ConclusionThis review concluded that there is a large gap in the primary literature for evidence‐based recommendations on the design and establishment of cancer registries. The included articles established a small scope of relevant themes, which were largely non‐specific. This area of deficiency provides an opportunity for future research, which would further strengthen the quality of current or new guidelines in cancer registry establishment.
Prediction of response to anti‐vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography‐based machine learning method
Authors: Cao Jing , You Kun , Jin Kai , Lou Lixia , Wang Yao , Chen Menglu , Pan Xiangji , Shao Ji , Su Zhaoan , Wu Jian , Ye Juan 
Published: June 2020

AbstractPurposeTo predict the anti‐vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at the initiation stage of treatment using a machine learning‐based self‐explainable system.MethodsA total of 712 DME patients were included and classified into poor and good responder groups according to central macular thickness decrease after three consecutive injections. Machine learning models were constructed to make predictions based on related features extracted automatically using deep learning algorithms from OCT scans at baseline. Five‐fold cross‐validation was applied to optimize and evaluate the models. The model with the best performance was then compared with two ophthalmologists. Feature importance was further investigated, and a Wilcoxon rank‐sum test was performed to assess the difference of a single feature between two groups.ResultsOf 712 patients, 294 were poor responders and 418 were good responders. The best performance for the prediction task was achieved by random forest (RF), with sensitivity, specificity and area under the receiver operating characteristic curve of 0.900, 0.851 and 0.923. Ophthalmologist 1 and ophthalmologist 2 reached sensitivity of 0.775 and 0.750, and specificity of 0.716 and 0.821, respectively. The sum of hyperreflective dots was found to be the most relevant feature for prediction.ConclusionAn RF classifier was constructed to predict the treatment response of anti‐VEGF from OCT images of DME patients with high accuracy. The algorithm contributes to predicting treatment requirements in advance and provides an optimal individualized therapeutic regimen.
Epidemiology and management of appendicular fractures occurring in neonatal intensive care patients
Authors: Williams Brendan A. , Makarewich Christopher A. , Montoya‐Williams Diana C. , Krakow Arielle , Lioy Janet , Horn B. David 
Published: June 2020

AbstractAimTo describe the epidemiology and management of appendicular fractures occurring in the neonatal ICU in a large series of patients treated a single, quaternary care neonatal intensive care unit.MethodsPatients <1 years old with appendicular fractures treated from 2012 to 2016 at a quaternary‐level NICU were identified. Bivariate testing compared fractures, work‐up and management based on designated mechanism (presumed birth‐related vs unknown). In patients with unknown mechanism, factors with potential fracture association were analysed in a descriptive fashion.ResultsEighty‐five fractures (54 patients) were included. Mechanistic cohorts differed by birthweight (P < .001) and gestational age at birth (P < .001). Presumed birth‐related fractures were more commonly upper extremity (P < .001), solitary (P = .001) and radiographically diagnosed in the acute state (<.001). The biochemical profile of the cohorts differed significantly. The prevalence of factors with potential fracture association was high in patients with unknown mechanism. Only one patient required surgery, while all others resolved with minimal orthopaedic intervention.ConclusionFindings indicate these injuries rarely require operative intervention and that two distinct injury profiles appear to exist based on fracture mechanism. Steroid use, ventilation use, diuretic use, nutritional supplementation and recent bedside procedures were common among patients without known fracture mechanism.Level of EvidenceLevel III—Retrospective Cohort Study.
Intestinal epithelial ablation of Pit‐2/Slc20a2 in mice leads to sustained elevation of vitamin D3 upon dietary restriction of phosphate
Authors: Pastor‐Arroyo Eva M. , Knöpfel Thomas , Imenez Silva Pedro H. , Schnitzbauer Udo , Poncet Nadège , Biber Jürg , Wagner Carsten A. , Hernando Nati 
Published: June 2020

AbstractAimSeveral Na+‐dependent phosphate cotransporters, namely NaPi‐IIb/SLC34A2, Pit‐1/SLC20A1 and Pit‐2/SLC20A2, are expressed at the apical membrane of enterocytes but their contribution to active absorption of phosphate is unclear. The aim of this study was to compare their pattern of mRNA expression along the small and large intestine and to analyse the effect of intestinal depletion of Pit‐2 on phosphate homeostasis.MethodsIntestinal epithelial Pit‐2‐deficient mice were generated by crossing floxed Pit‐2 with villin‐Cre mice. Mice were fed 2 weeks standard or low phosphate diets. Stool, urine, plasma and intestinal and renal tissue were collected. Concentration of electrolytes and hormones, expression of mRNAs and proteins and intestinal transport of tracers were analysed.ResultsIntestinal mRNA expression of NaPi‐IIb and Pit‐1 is segment‐specific, whereas the abundance of Pit‐2 mRNA is more homogeneous. In ileum, NaPi‐IIb mRNA expression is restricted to enterocytes, whereas Pit‐2 mRNA is found in epithelial and non‐epithelial cells. Overall, their mRNA expression is not regulated by dietary phosphate. The absence of Pit‐2 from intestinal epithelial cells does not affect systemic phosphate homeostasis under normal dietary conditions. However, in response to dietary phosphate restriction, Pit‐2‐deficient mice showed exacerbated hypercalciuria and sustained elevation of 1,25(OH)2 vitamin D3.ConclusionsIn mice, the intestinal Na+/phosphate cotransporters are not coexpressed in all segments. NaPi‐IIb but not Pit‐2 mRNA is restricted to epithelial cells. Intestinal epithelial Pit‐2 does not contribute significantly to absorption of phosphate under normal dietary conditions. However, it may play a more significant role upon dietary phosphate restriction.
Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
Authors: Dhanda Ashwin , Atkinson Stephen , Vergis Nikhil , Enki Doyo , Fisher Andrew , Clough Robert , Cramp Matthew , Thursz Mark 
Published: June 2020

SummaryBackgroundMalnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis.AimTo determine the prevalence of trace element deficiency and its association with clinical outcomes in patients with alcoholic hepatitis.MethodsSerum was obtained from patients with alcoholic hepatitis, alcohol‐related cirrhosis and healthy volunteers as part of clinical trials, cohort studies and a biobank. Trace element concentration was measured by inductively coupled plasma mass spectrometry. Association of trace element levels with development of infection within 90 days and mortality within 28 and 90 days was evaluated by multivariate logistic regression.ResultsSera from 302 patients with alcoholic hepatitis, 46 with alcohol‐related cirrhosis and 15 healthy controls were analysed for trace element concentration. The prevalence of zinc deficiency (85%) and selenium deficiency (67%) in alcoholic hepatitis was higher than in alcohol‐related cirrhosis (72% [p=0.04] and 37% [p<0.001], respectively). Zinc, selenium, copper and chromium were significantly different between groups. Iron deficiency was a predictor of development of infection within 90 days. Zinc deficiency was a predictor of mortality within 28 and 90 days.ConclusionTrace element deficiency in patients with alcoholic hepatitis is highly prevalent and associated with infection and mortality. Supplementation with selected trace elements may improve clinical outcomes in this patient group but further insight is required of their biological and clinical effects.