bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient nonparametric estimation for skewed distributions
Authors: Favre‐Martinoz Cyril , Haziza David , Beaumont Jean‐François 
Published: October 2020

AbstractMany variables encountered in practice have skewed distributions. While the sample mean is unbiased for the true mean regardless of the underlying distribution that generated the sample observations, it can be highly unstable in the context of skewed distributions. To cope with this problem, we propose an efficient estimator of the population mean based on the concept of conditional bias of a unit, which can be viewed as a measure of its influence. The idea is to reduce the impact of the sample units that have a large influence. The resulting estimator depends on a cut‐off value. We suggest selecting the cut‐off value that minimizes the maximum absolute estimated conditional bias with respect to the proposed estimator. An estimator of the mean square error is also presented. An empirical investigation comparing several estimators in terms of relative bias and relative efficiency suggests that the proposed estimator and the estimator of its mean square error perform well for a wide class of distributions.
Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect
Authors: Schneider Frank , Stamler David , Bradbury Margaret , Loupe Pippa S. , Hellriegel Edward , Cox Donna S. , Savola Juha‐Matti , Gordon Mark Forrest , Rabinovich‐Guilatt Laura 
Published: October 2020

AbstractDeutetrabenazine (Austedo, Teva), an approved treatment of chorea in Huntington's disease and tardive dyskinesia in adult patients, is a rationally designed deuterated form of tetrabenazine. Two studies assessed the pharmacokinetics and safety of deutetrabenazine compared with tetrabenazine, and the effects of food on absorption of the deuterated active metabolites, α‐dihydrotetrabenazine (α‐HTBZ) and β‐dihydrotetrabenazine (β‐HTBZ). One study was an open‐label 2‐part study in healthy volunteers; the first part included a crossover single dose of two 15 mg candidate deutetrabenazine formulations in fed and fasted states compared with tetrabenazine 25 mg in the fasted state, and the second part included single and repeated dosing of the commercial formulation of deutetrabenazine (7.5, 15, and 22.5 mg) compared with tetrabenazine 25 mg. The second study was an open‐label 5‐way crossover study in healthy volunteers (n = 32) to evaluate relative bioavailability of 4 dose levels of the commercial formulation of deutetrabenazine (6, 12, 18, and 24 mg) with a standard meal and 18 mg with a high‐fat meal. Both studies confirmed longer half‐lives for active metabolites and lower peak‐to‐trough fluctuations for the sum of the metabolites (total [α+β]‐HTBZ) following deutetrabenazine compared with tetrabenazine (3‐ to 4‐fold and 11‐fold, respectively) in steady‐state conditions. Deutetrabenazine doses estimated to provide total (α+β)‐HTBZ exposure comparable to tetrabenazine 25 mg were 11.4‐13.2 mg. Food had no effect on exposure to total (α+β)‐HTBZ, as measured by AUC. Although the total (α+β)‐HTBZ Cmax of deutetrabenazine was increased by ≈50% in the presence of food, it remained lower than that of tetrabenazine.
A Pyridine‐Acetylene‐Aniline Oligomer: Saccharide Recognition and Influence of this Recognition Array on the Activity as Acylation Catalyst
Authors: Ohishi Yuki , Takata Toshikazu , Inouye Masahiko 
Published: October 2020

AbstractIn order to create new functions of foldamer‐type hosts, various kinds of recognition arrays are expected to be developed. Here, a pyridine‐acetylene‐aniline unit is presented as a new class of a saccharide recognition array. The conformational stabilities of this array were analyzed by DFT calculation, and suggested that a pyridine‐acetylene‐aniline oligomer tends to form a helical structure. An oligomer of this array was synthesized, and its association for octyl β‐D‐glucopyranoside was confirmed by 1H NMR measurements. UV/Vis, circular dichroism, and fluorescence titration experiments revealed its high affinity for octyl glycosides in apolar solvents (Ka=104 to 105 M−1). This oligomer was relatively stable under basic conditions, and therefore this array was expected to be applied to the derivatization of saccharides. A 4‐(dialkylamino)pyridine attached pyridine‐acetylene‐aniline oligomer proved to catalyze the acylation of the octyl glucoside.
Videotherapy and therapeutic alliance in the age of COVID‐19
Authors: Simpson Susan , Richardson Lisa , Pietrabissa Giada , Castelnuovo Gianluca , Reid Corinne 
Published: October 2020

AbstractThe arrival of the coronavirus (COVID‐19) pandemic has confronted us with a global and unprecedented challenge of community‐wide psychological distress alongside reduced access to therapeutic services in the traditional face‐to‐face format, due to the need to self‐isolate. This previously unimagineable set of circumstances provides a unique opportunity, and indeed an imperative, for videotherapy to fulfil its potential in addressing mental health and well‐being needs from a distance. Historically, the uptake of videotherapy has been hindered by psychotherapist expectations of inferior therapeutic alliance and outcomes, in spite of considerable research evidence to the contrary. Research suggests that videotherapy provides a powerful pathway for clients to experience enhanced opportunities for self‐expression, connection and intimacy. This more neutral therapeutic ‘space’ provides clients with multifarious opportunities for self‐awareness, creative experience and collaboration, with potentially a greater sense of agency over their own experience. This paper explores ways in which videotherapy can lead to a revitalisation of the concept of the therapeutic relationship, in order to meet the challenges associated with COVID‐19. A number of specific considerations for videotherapy adaptations and etiquette in the midst of COVID‐19 are described.
Photoinduced Electron Transfer in Axially Coordinated Supramolecular Zinc Tetrapyrrole Bis(styryl)BODIPY Donor‐Acceptor Conjugates
Authors: Benitz Alejandro , Thomas Michael B. , de Silva Imesha , Nesterov Vladimir N. , Verbeck Guido F. , D'Souza Francis 
Published: October 2020

AbstractPhotoinduced electron transfer (PET) in newly assembled dyads formed via metal‐ligand axial coordination of phenylimidazole‐functionalized bis(styryl)BODIPY (BODIPY(Im)2) and zinc tetrapyrroles, that is, zinc tetratolylporphyrin (ZnP), zinc tetra‐t‐butyl phthalocyanine (ZnPc) and zinc tetra‐t‐butyl naphthalocyanine (ZnNc), in non‐coordinating o‐dichlorobenzene (DCB) is investigated using both steady‐state and time‐resolved transient absorption techniques. The structure of the BODIPY(Im)2 was identified by using single crystal X‐ray structural analysis. The newly formed supramolecular dyads were fully characterized by spectroscopic, computational and electrochemical methods. The binding constants measured from optical absorption spectral studies were in the range of ∼104 M−1 for the first zinc tetrapyrrole binding and suggested that the two imidazole entities of bis(styryl)BODIPY behave independently in the binding process. The energy level diagram established using spectral and electrochemical studies suggested PET to be thermodynamically unfavorable in the ZnP‐bearing complex while for ZnPc‐ and ZnNc‐bearing complexes such a process is possible when zinc tetrapyrrole is selectively excited. Consequently, occurrence of efficient PET in the latter two dyads was possible to establish from femtosecond transient absorption studies wherein the electron transfer products, that is, the radical cation of zinc tetrapyrrole and the radical anion of BODIPY(Im)2, was possible to spectrally identify. From target analysis of the transient data, time constants of circa 3 ns for ZnPc⋅+:BODIPY⋅− and circa 0.5 ns for ZnNc⋅+:BODIPY⋅− were obtained indicating persistence of the radical ion‐pair to some extent. The electron acceptor property of bis(styryl)BODIPY in donor‐acceptor conjugates is borne out from the present study.
Severe delayed pulmonary toxicity following PD‐L1–specific CAR‐T cell therapy for non‐small cell lung cancer
Authors: Liu Heping , Ma Yuxiang , Yang Chaopin , Xia Shangzhou , Pan Qiuzhong , Zhao Hongyun , Fang Wenfeng , Chen Xi , Zhang Yang , Zou Benyan , Li Qiuyuan , Wan Yang , Chen Hao , Tang Yan , Zhao Jingjing , Weng Desheng , Xia Liming , Zhang Li , Xia Jianchuan 
Published: October 2020

AbstractObjectivesThis phase I study aimed to evaluate the antitumor effect and safety of programmed death‐ligand‐1 (PD‐L1)–targeting autologous chimeric antigen receptor T (CAR‐T) cells for patients with non‐small cell lung cancer (NSCLC).MethodsProgrammed death‐ligand‐1–specific CAR‐T cells were generated using lentiviral transduction. Four patients with NSCLC were recruited, but only one patient was finally involved. CAR‐T cells were infused on three different days (total dose during therapy, 1 × 106 CAR‐T cells kg−1 body weight). The date on which the patient received the first CAR‐T cell infusion was designated as Day 0.ResultsCirculating CAR‐T cells accounted for 3.30% of the patient’s peripheral blood T cells detected by FACS analysis during the first follow‐up (Day +29). The chest CT scan showed subtle tumor shrinkage (stable disease). On Day +43, the patient developed pyrexia without any known causes and dyspnoea that rapidly deteriorated to respiratory failure in 3 days. The chest X‐ray and CT scan showed bilateral extensive pulmonary infiltration in addition to the tumor silhouette on the left upper lung. The interleukin (IL)‐6 levels in serum dramatically increased (> 100‐fold). The patient was immediately transferred to the ICU where he received oxygen and intravenous infusions of tocilizumab and methylprednisolone. His symptoms rapidly improved and the pulmonary inflammation gradually resolved.ConclusionThe clinical manifestations and test findings for this patient with NSCLC might represent unique clinical manifestations of solitary organ damage secondary to PD‐L1–specific CAR‐T cell therapy. The differential diagnosis, underlying mechanism and prevention and treatment strategies for such complications have also been discussed.
Transient inconsistency between population density and fisheries yields without bycatch species extinction
Authors: Chen Renfei 
Published: October 2020

AbstractRecent studies have demonstrated the great advantages of marine reserves in solving bycatch problems by maintaining the persistence (i.e., avoid extinction) of endangered species without sacrificing the fisheries yields of target species. However, transient phenomena rather than equilibrium states of population dynamics still require further research. Here, with a simple and general model, the transient dynamics of the target fish species are investigated under management which minimizes extinction risk of the bycatch species. An interesting finding is that fisheries yields can strongly fluctuate even if population density both inside and outside marine reserve only slightly varies (or vice versa), leading to transient inconsistency between the population densities and fisheries yields. This finding suggests that population density dynamics of the target fish species cannot be used to predict the transient phenomena of fisheries yields (or vice versa) in fisheries management. However, the unpredictability can be receded as the sensitivity analyses show that a large marine reserve size and low escapement rate can shorten the transient duration.
Mechanical circulatory support does not reduce advanced myocardial fibrosis in patients with end‐stage heart failure
Authors: Kassner Astrid , Oezpeker Cenk , Gummert Jan , Zittermann Armin , Gärtner Anna , Tiesmeier Jens , Fox Henrik , Morshuis Michiel , Milting Hendrik 
Published: October 2020

AimsMechanical unloading by ventricular assist devices (VADs) has become increasingly important for the therapy of end‐stage heart failure during the last decade. However, VAD support was claimed to be associated with partial reverse remodelling. Unfortunately, the literature describes the contradictory effects of VAD systems on cardiac fibrosis, a hallmark of cardiac remodelling. To clarify these inconsistent results, the effects on cardiac fibrosis before and after mechanical unloading in 125 patients were examined.Methods and resultsLeft ventricular myocardial tissue from ischaemic or non‐ischaemic cardiomyopathy patients undergoing VAD implantation and subsequent cardiac transplantation and non‐failing hearts of the control group were analysed for 4‐hydroxyproline (4OH‐P) content as a marker for collagen protein. In addition, collagen cross‐linking and mRNAs of collagens I and III and transforming growth factor beta‐1 were measured. 4OH‐P content was significantly increased in failing hearts compared with the control group and increased (P < 0.05) after mechanical unloading (nmol/mg tissue, mean ± standard deviation: 16.74 ± 9.68 vs. 7.75 ± 2.39 and 18.57 ± 9.19). However, plotting of the 4OH‐P ratios (post/pre‐VAD) against the collagen content pre‐VAD could be fitted by non‐linear regression. Collagen cross‐linking correlated strongly with the total collagen content in pre‐ and post‐VAD myocardium (r2 = 0.73 and 0.71, respectively). In contrast to the total collagen content, all three mRNAs of fibrotic genes were significantly down‐regulated during VAD support when compared to pre‐VAD.ConclusionsThis investigation of a comparably large patient cohort revealed that cardiac fibrosis was strongly increased in heart failure and increased even after mechanical unloading. The mRNAs of collagens I and III are independently regulated from the collagen protein.
Effectiveness of Protective Preparations: Impact of Vegetable Oil Additives to Recipes
Authors: Kulawik‐Pióro Agnieszka , Klimaszewska Emilia , Ogorzałek Marta , Ruman Justyna , Rożnawska Klaudia 
Published: October 2020

AbstractThe aim of the study is to demonstrate the effect of the addition of vegetable oils rich in EFA on the effectiveness of hydrophobic skin protection preparations intended for work in the wet environment. The research hypothesis assumes that the increase in the concentration of vegetable oils in the formula of protective preparations improves their spreadability on the skin, thus translating into acceptance of the preparations by users, improving their quality of life, strengthening the barrier functions of the skin without reducing the effectiveness of the protective action. The distribution capacity of pure vegetable oils is determined using instrumental analysis and sensory analysis. Also, TEWL tests are used to evaluate their occlusal properties. For protective preparations based on them, the distribution capacity is tested by in vitro methods as well as in vivo tests and sensory analyses are performed. The effectiveness of the tested preparations is measured by tests concerning absorbability, occlusion capacity and washability. The results are analyzed and compared, and a correlation matrix is developed to establish the relationship between sensory and instrumental measurements. The effectiveness of the preparations depends on the type of oil (its spreadability and viscosity) and the amount in the formulation.Practical Applications: For hydrophobic preparations of ointment type, there is a possibility to implement such instrumental techniques as: determination of preparation consistency by means of a cone, ability to distribute by means of parallel plates, but also determination of preparation viscosity by rheological methods. Viscosity, spreading ability, and oil occlusion ability are the most important parameters that should be taken into account when we design hydrophobic skin protection preparations intended for the works in the wet environment.
Morphodynamic research challenges for braided river environments: Lessons from the iconic case of New Zealand
Authors: Hicks D.M. , Baynes E.R.C. , Measures R. , Stecca G. , Tunnicliffe J. , Friedrich H. 
Published: October 2020

AbstractPressures on braided river systems in New Zealand are increasing due to anthropogenic stresses such as demand for irrigation water, braidplain conversion to farmland and invasive vegetation, as well as extreme natural events associated with earthquakes and climate change. These pressures create issues around preserving braided river physical environments and associated ecosystems, and managing hazards such as floods, aggradation and erosion. A need for more robust understanding and quantification of braided river morphodynamic processes underpins many of these issues. Here, we present eight morphodynamic research challenges to service this need. The first four research challenges relate to managing aggradation‐related flooding hazards; the last four address issues stem largely from recent dairy expansion, which has created huge pressure to take land and irrigation water from the alp‐fed braided rivers and to alter flow regimes at their mouths. Hāpua, the freshwater lagoons found where most braided rivers meet the coast, show complex morphodynamic behaviour in response to the interplay of river and coastal processes, and their special ecosystems are sensitive to river flow and sediment load changes. We discuss how physical laboratory experiments and novel numerical modelling can help to understand the morphological processes braided rivers undergo, and we show how those research advances could inform planning and legal decisions to regulate land rights and irrigation water allocation on New Zealand's braidplains. We illustrate these environmental and engineering issues and research challenges with examples from the Kowhai, Waiho, Waiau, Rangitata and Hurunui Rivers. © 2020 John Wiley & Sons, Ltd.
High‐resolution fjord sediment record of a receding glacier with growing intermediate proglacial lake (Steffen Fjord, Chilean Patagonia)
Authors: Piret Loic , Bertrand Sebastien , Hawkings Jon , Kylander Malin E. , Torrejón Fernando , Amann Benjamin , Wadham Jemma 
Published: October 2020

AbstractProglacial lakes are effective sediment traps but their impact on the reliability of downstream sediment records to reconstruct glacier variability remains unclear. Here, we investigate the sedimentary signature of the recent recession of Steffen Glacier (Chilean Patagonia, 47°S) in downstream fjord sediments, with a focus on identifying the trapping (decreased downstream sediment yield) and filtering (removal of coarse particles) effectiveness of a growing intermediate proglacial lake. Four sediment cores were collected along a 14 km longitudinal transect in Steffen Fjord and the sediment physical and chemical properties were compared with aerial imagery at high temporal resolution. The caesium‐137 (137Cs) chronology of the most distal core and sediment trap data suggest that sediment accumulation in the fjord remained relatively stable through time, despite the accelerating glacier recession and the growth of Steffen proglacial lake. This is in contrast with many studies that indicate a decrease in sediment yield during proglacial lake expansion. It implies that the increase in sediment export due to accelerating meltwater production may be balanced by the sediment trapping effect of the growing proglacial lake. The fjord sediments show a slight fining upward accompanied by a marked decrease in flood‐induced grain‐size peaks, most likely due to the increasing filtering and dampening effect of the expanding proglacial lake. Our findings show that the filtering effect of the proglacial lake reached a threshold in 1985, when the lake attained an area of 2.02 km2. The additional 5 km of glacier recession during the following 32 years did not have any significant impact on downstream sedimentation. This study confirms that proglacial lakes act as sediment traps but it indicates that (1) the trapping effect can be outpaced by accelerating glacier recession and (2) the filtering effect becomes stable once the lake attains a certain critical size. © 2020 John Wiley & Sons, Ltd.
Biogeomorphology, quo vadis? On processes, time, and space in biogeomorphology
Authors: Larsen A. , Nardin W. , van de Lageweg W.I. , Bätz N. 
Published: October 2020

AbstractBiogeomorphology has been expanding as a discipline, due to increased recognition of the role that biology can play in geomorphic processes, as well as due to our increasing capacity to measure and quantify feedback between biological and geomorphological systems. Here, we provide an overview of the growth and status of biogeomorphology. This overview also provides the context for introducing this special issue on biogeomorphology, and specifically examines the thematic domains of biogeomorphological research, methods used, open questions and conundrums, problems encountered, future research directions, and practical applications in management and policy (e.g. nature‐based solutions). We find that whilst biogeomorphological studies have a long history, there remain many new and surprising biogeomorphic processes and feedbacks that are only now being identified and quantified. Based on the current state of knowledge, we suggest that linking ecological and geomorphic processes across different spatio‐temporal scales emerges as the main research challenge in biogeomorphology, as well as the translation of biogeomorphic knowledge into management approaches to environmental systems. We recommend that future biogeomorphic studies should help to contextualize environmental feedbacks by including the spatio‐temporal scales relevant to the organism(s) under investigation, using knowledge of their ecology and size (or metabolic rate). Furthermore, in order to sufficiently understand the ‘engineering’ capacity of organisms, we recommend studying at least the time period bounded by two disturbance events, and recommend to also investigate the geomorphic work done during disturbance events, in order to put estimates of engineering capacity of biota into a wider perspective. Finally, the future seems bright, as increasingly inter‐disciplinary and longer‐term monitoring are coming to fruition, and we can expect important advances in process understanding across scales and better‐informed modelling efforts. © 2020 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd
Characteristics on the oxidation stability of infant formula powder with different ingredients during storage
Authors: Wang Weijun , Li Yanhua , Cai Liqin , Fang Luping 
Published: October 2020

AbstractInfant formula powder is prone to oxidation reaction during storage, which leads to the decrease of milk powder quality. The whole milk powder (WMP) was formulated, and the characteristics of infant formula powder were tracked during storage. The addition of metal ions, polyunsaturated fatty acids, and vitamins could reduce the peroxide value and increase the thiobarbituric acid value in the infant formula powder during the early stage of storage. When the samples were stored for 6 months, the free fat content of the base milk powder and the sample added with metal ions had high level (3.3%–3.6%). With adding vitamins, the content of free fat in the samples decreased first and then increased. The color value L of all the samples decreased during storage. Compared with WMP, the color value B of all the infant formula powder with different ingredients decreased. Levels of 2‐heptanone and 2‐nonaone indicated that the formation of the main methyl ketones in the infant formula powder with different ingredients decreased. The content of hexanal in the sample added metal ions was the highest. The type and intensity of free radicals changed with the formula components. The range of g value was 2.0043–2.0060 after 6 months of storage and 2.0017–2.1338 after 12 months of storage, respectively. The index of peroxide value and color value B were significantly related to the existence of free radicals in the infant formula powder with different ingredients.