bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatility and asymmetric dependence in Central and East European stock markets
Authors: Joseph Nathan Lael , Vo Thi Thuy Anh , Mobarek Asma , Mollah Sabur 
Published: March 2020

AbstractWe study the effects of contagion around the global financial crisis (GFC) and the Eurozone crisis periods using German and UK returns, each paired with returns from Central and East European (CEE) stock markets that recently joined the European Union (EU). Using bivariate vector error-correction models (VECMs) estimated in GARCH(1,1), we find strong support for long-run equilibrium conditions. This finding suggests that tests of tail dependence using differenced VARs may be mis-specified when long-run equilibrium conditions apply. Past news has more persistence on current volatility in CEE markets than in the developed markets. Past volatility has more persistence in the developed markets compared to the CEE markets. The T-V symmetrized Joe–Clayton (T-V SJC) copula outperforms all other copulas in goodness-of-fit, including, the T-V Gaussian and Studenttcopulas. This result is supported by a differenced VAR-GARCH (1,1). For CEE and developed market returns, no more than half of our market pairs exhibit significant increases in lower tail dependence, under the T-V SJC copula. Given the number of paired comparisons, the evidence on joint extreme dependence is weak. As such, CEE stock markets experienced little contagion effects during the GFC and Eurozone crisis periods, contrary to prior results. We find that the legal environment negatively impacts financial development, perhaps causing CEE and the EU markets to be isolated.
Application of Multivariate Statistical Analysis for Valuation of Copyrights in the Hotel Industry
Authors: Kossecki Paweł , Kossecki Stefan 
Published: March 2020

AbstractThe aim of this work was to identify comparable markets for the hotel industry in Europe and to compare the fees incurred by hotels for using copyrighted and indirect rights for copyright management organizations. The study covers 21 European countries. Using multivariate statistical analysis methods, these countries were grouped, taking into account gross domestic product per capita and the average daily rate for a hotel room. A detailed comparison of the fees that hotels pay for using music and audiovisual works was conducted for the Central and Eastern European countries characterized by the lowest income and hotel prices. The analysis identified wide variation in the methods for calculating fees, fee amounts, and the relationship to hotel revenues among the various countries.
Täterinnen
Authors: Leuschner Fredericke 
Published: March 2020

ZusammenfassungRegelmäßig wurde in der Literatur der Frage nachgegangen, wieso Frauen weniger kriminell sind als Männer. Da es nicht ausreicht, einfach nur Ursachen für unterschiedliche Kriminalitätsbelastungen im Allgemeinen zu finden, sondern die Tatstrukturen und Hintergründe von Taten durch Frauen betrachtet werden müssen, um Kriminalität von Frauen zu verstehen, werden in diesem Beitrag verschiedene, häufig durch Frauen begangene Delikte kursorisch dargestellt. Im Detail handelt es sich um Gewaltdelikte (Kindesmisshandlungen und -tötungen sowie Gewalt in Paarbeziehungen und der Altenpflege), Stalking, Vermögensdelikte und Falschaussagen. Dadurch werden Szenarien, Motivlagen und Risikofaktoren erkennbar, die kriminelle Aktivitäten von Frauen fördern.
Clarifying the Normative Significance of ‘Personality Changes’ Following Deep Brain Stimulation
Authors: Pugh Jonathan 
Published: March 2020

AbstractThere is evidence to suggest that some patients who undergo Deep Brain Stimulation can experience changes to dispositional, emotional and behavioural states that play a central role in conceptions of personality, identity, autonomy, authenticity, agency and/or self (PIAAAS). For example, some patients undergoing DBS for Parkinson’s Disease have developed hypersexuality, and some have reported increased apathy. Moreover, experimental psychiatric applications of DBS may intentionally seek to elicit changes to the patient’s dispositional, emotional and behavioural states, in so far as dysfunctions in these states may undergird the targeted disorder. Such changes following DBS have been of considerable interest to ethicists, but there is a considerable degree of conflict amongst different parties to this debate about whether DBS really does change PIAAAS, and whether this matters. This paper explores these conflicting views and suggests that we may be able to mediate this conflict by attending more closely to what parties to the debate mean when they invoke the concepts lumped together under the acronym PIAAAS. Drawing on empirical work on patient attitudes, this paper outlines how these different understandings of the concepts incorporated into PIAAAS have been understood in this debate, and how they may relate to other fundamental concepts in medical ethics such as well-being and autonomy. The paper clarifies some key areas of disagreement in this context, and develops proposals for how ethicists might fruitfully contribute to future empirical assessments of apparent changes to PIAAAS following DBS treatment.
Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics
Authors: Liu D. , Qiu X. , Xiong X. , Chen X. , Pan F. 
Published: March 2020

AbstractBladder cancer (BCa) is the fourth most common urological malignancy in the world, it has become the costliest cancer to manage due to its high rate of recurrence and lack of effective treatment modalities. As a natural byproduct of cellular metabolism, reactive oxygen species (ROS) have an important role in cell signaling and homeostasis. Although up-regulation of ROS is known to induce tumorigenesis, growing evidence suggests a number of agents that can selectively kill cancer cells through ROS induction. In particular, accumulation of ROS results in oxidative stress-induced apoptosis in cancer cells. So, ROS is a double-edged sword. A modest level of ROS is required for cancer cells to survive, whereas excessive levels kill them. This review summarizes the up-to-date findings of oxidative stress-regulated signaling pathways and transcription factors involved in the etiology and progression of BCa and explores the possible therapeutic implications of ROS regulators as therapeutic agents for BCa.
Perceptions About the Labor Market Integration of Refugees: Evidences from Syrian Refugees in Jordan
Authors: Sahin Mencutek Zeynep , Nashwan Ayat J. 
Published: March 2020

AbstractThis article focuses on the refugees’ labor market integration in the immediate host countries. Drawing from the experience of Syrian refugees in Jordan, it describes how the integration in labor market depends on the alignment of four perspectives: (1) host state perspective, materialized through legal regulations about refugee employment; (2) refugee perspective that refers to refugees’ access to labor market and challenges they face; (3) host community perspective that implies to the recognition, approval, or reactions of host communities to the refugee employment; and (4) donor perspective that appears with the intervention of international actors through development aid or general support to refugees’ working rights. To explore these diverging perspectives and their implications about the labor market integration of Syrian refugees in Jordan, the data is gathered from ethnographic policy analysis and stakeholder interviews in urban areas and camps. We argue that the refugees’ legal right to work is one of the most contentious policy issues not only for Jordanian state but also for its relations with Jordanian citizens, refugees, and donors. From the perspective of donors, ensuring Syrians’ legal access to labor market in the immediate host countries, like Jordan, is a policy tool for keeping refugees in the origin region. At the host community level, the issue appears as a source of dilemma; because refugee employment is a critical domain for refugees’ self-reliance and local integration on the one hand, it is perceived as the source of competition for already scarce job opportunities on the other hand. For refugees themselves, an access to labor market and getting support are ways of gaining sustainable livelihood opportunities, self-reliance, and dignity. However, this access is marked by severe conditions of exploitation, vulnerability, and discrimination in working places as well as the anti-refugee rhetoric of local host communities. Programming in refugee employment necessitates taking all these four perspectives into account.
A review on reflection-waveform inversion
Authors: Yao Gang , Wu Di , Wang Shang-Xu 
Published: March 2020

AbstractFull-waveform inversion (FWI) utilizes optimization methods to recover an optimal Earth model to best fit the observed seismic record in a sense of a predefined norm. Since FWI combines mathematic inversion and full-wave equations, it has been recognized as one of the key methods for seismic data imaging and Earth model building in the fields of global/regional and exploration seismology. Unfortunately, conventional FWI fixes background velocity mainly relying on refraction and turning waves that are commonly rich in large offsets. By contrast, reflections in the short offsets mainly contribute to the reconstruction of the high-resolution interfaces. Restricted by acquisition geometries, refractions and turning waves in the record usually have limited penetration depth, which may not reach oil/gas reservoirs. Thus, reflections in the record are the only source that carries the information of these reservoirs. Consequently, it is meaningful to develop reflection-waveform inversion (RWI) that utilizes reflections to recover background velocity including the deep part of the model. This review paper includes: analyzing the weaknesses of FWI when inverting reflections; overviewing the principles of RWI, including separation of the tomography and migration components, the objective functions, constraints; summarizing the current status of the technique of RWI; outlooking the future of RWI.
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
Authors: Amaya-Montoya Mateo , Pérez-Londoño Agustín , Guatibonza-García Valentina , Vargas-Villanueva Andrea , Mendivil Carlos O. 
Published: March 2020

AbstractLife expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell cycle arrest with suppressed apoptosis and concomitant secretion of multiple bioactive factors (the senescence-associated secretory phenotype—SASP) that plays a physiological role in embryonic development and healing processes. However, DNA damage and oxidative stress that occur during aging cause the accumulation of senescent cells, which through their SASP bring about deleterious effects on multiple organ and systemic functions. Ablation of senescent cells through genetic or pharmacological means leads to improved life span and health span in animal models, and preliminary evidence suggests it may also have a positive impact on human health. Thus, strategies to reduce or eliminate the burden of senescent cells or their products have the potential to impact multiple clinical outcomes with a single intervention. In this review, we touch upon the basics of cell senescence and summarize the current state of development of therapies against cell senescence for human use.
Acute myocardial infarction in adolescents: reappraisal of underlying mechanisms
Authors: van der Schoot G. G. F. , Anthonio R. L. , Jessurun G. A. J. 
Published: March 2020

AbstractWorldwide, a myocardial infarction (MI) is an important cause of death. Acute MI occurs most commonly at an older age. However, the incidence of acute MI in adolescents is increasing. This is partly due to an increase in cardiovascular risk factors (e.g. smoking, unhealthy diet), which might lead to premature atherosclerosis. However, several non-atherosclerotic causes of MI in adolescents are also described in the literature, such as vascular spasm due to the use of cocaine. We may assume that acute MI is not considered to be the most likely cause of chest pain in adolescents. Therefore, the risk of a dramatic outcome in this patient category may be significant. This point of view article addresses the pathophysiological process and subsequent diagnostic approach in adolescents with MI resulting from either premature atherosclerosis or of non-atherosclerotic causes. Insight into the potential operational mechanisms of the coronary artery incident may have a major impact on the clinical course following admission. We would like to underline that a personalised clinical approach remains of utmost importance in each patient treated by protocolised medicine. This is particularly true when acute MI occurs at a young age, since the underlying cause more frequently differs from the conventional atherosclerotic process in this patient category.
Biological phase separation: cell biology meets biophysics
Authors: Yoshizawa Takuya , Nozawa Ryu-Suke , Jia Tony Z. , Saio Tomohide , Mori Eiichiro 
Published: March 2020

AbstractProgress in development of biophysical analytic approaches has recently crossed paths with macromolecule condensates in cells. These cell condensates, typically termed liquid-like droplets, are formed by liquid-liquid phase separation (LLPS). More and more cell biologists now recognize that many of the membrane-less organelles observed in cells are formed by LLPS caused by interactions between proteins and nucleic acids. However, the detailed biophysical processes within the cell that lead to these assemblies remain largely unexplored. In this review, we evaluate recent discoveries related to biological phase separation including stress granule formation, chromatin regulation, and processes in the origin and evolution of life. We also discuss the potential issues and technical advancements required to properly study biological phase separation.
Intelligent User Assistance for Automated Data Mining Method Selection
Authors: Zschech Patrick , Horn Richard , Höschele Daniel , Janiesch Christian , Heinrich Kai 
Published: March 2020

AbstractIn any data science and analytics project, the task of mapping a domain-specific problem to an adequate set of data mining methods by experts of the field is a crucial step. However, these experts are not always available and data mining novices may be required to perform the task. While there are several research efforts for automated method selection as a means of support, only a few approaches consider the particularities of problems expressed in the natural and domain-specific language of the novice. The study proposes the design of an intelligent assistance system that takes problem descriptions articulated in natural language as an input and offers advice regarding the most suitable class of data mining methods. Following a design science research approach, the paper (i) outlines the problem setting with an exemplary scenario from industrial practice, (ii) derives design requirements, (iii) develops design principles and proposes design features, (iv) develops and implements the IT artifact using several methods such as embeddings, keyword extractions, topic models, and text classifiers, (v) demonstrates and evaluates the implemented prototype based on different classification pipelines, and (vi) discusses the results’ practical and theoretical contributions. The best performing classification pipelines show high accuracies when applied to validation data and are capable of creating a suitable mapping that exceeds the performance of joint novice assessments and simpler means of text mining. The research provides a promising foundation for further enhancements, either as a stand-alone intelligent assistance system or as an add-on to already existing data science and analytics platforms.
Farmed-raised fallow deer (Dama dama L.) carcass characteristics and meat nutritional value
Authors: Żmijewski Tomasz , Modzelewska-Kapituła Monika , Pomianowski Janusz , Ziomek Agata 
Published: March 2020

AbstractThis study analysed carcass features and the chemical composition of semimembranosus (SM) and longissimus thoracis et lumborum (LTL) muscles from farmed-raised fallow deer (Dama dama L.) bucks (n = 8). Mineral contents and fatty acid composition were also determined in the muscles and the fulfilment of the demand for minerals was calculated for adults. Dressing percentage was 55.2%, whereas the proportions of round, shoulder and loin were 38.4%, 15.5% and 14.4%, respectively. The highest content of meat tissue was found in round, followed by loin. There were no differences in moisture, fat, protein or ash contents between SM and LTL muscles, however differences in mineral contents and fatty acid composition were noted and affected the concentration of nutrients. Meat from farmed-raised fallow deer is a good source of iron and copper in the human diet and may be recommended as a part of a healthy diet.
Water quality analysis of Urun-Islampur City, Maharashtra, India
Authors: Kate Shrikant , Kumbhar Shridhar , Jamale Prajkta 
Published: March 2020

AbstractSafe drinking water is a human need and right of the people. This study focuses on water quality analysis of the Urun-Islampur city which is in the Maharashtra state of India. Water quality testing is very important to check the quality of drinking water to avoid waterborne diseases and improve health. Water Quality Index (WQI) is important to determine the depletion of the water quality of the study area. The Urun-Islampur city is divided into fourteen wards. The values of WQI of those fourteen wards were compared, where from each ward three water samples were taken for the test. In order to assess the water quality, we calculate the WQI with physical, chemical and biological parameters. In water quality tests, various parameters are measured, including pH, total hardness, chloride content (Cl−), electric conductivity, residual chlorine and total dissolved solids (TDS), all those parameters compared with World Health Organization (WHO) standards of water quality; also in the present research paper classification of water samples of the 14 wards was an investigation into the basis of TDS, anions, cations, and total hardness. This article highlights the importance of using the WQI, and it is very useful to analyze the water quality. After water sample testing, it was observed that the pH of all water samples was found almost neutral. The TDS, conductance and hardness increased toward the old water supply line as compared to a new water supply line. The results of the Water Quality Assessment done in Urun-Islampur city show that all parameters were within the permissible limits as per WHO standards. The Water Quality Index (WQI) in the range of 86 to 90 was also good. But it may be affected by water distribution lines which were older than 30 years, so there is a need for proper maintenance of the distribution system and chlorination to avoid waterborne diseases.
From Liquid- to Solid-State Batteries: Ion Transfer Kinetics of Heteroionic Interfaces
Authors: Weiss Manuel , Simon Fabian J. , Busche Martin R. , Nakamura Takashi , Schröder Daniel , Richter Felix H. , Janek Jürgen 
Published: March 2020

Abstract
Hybrid battery cells combining liquid electrolytes (LEs) with inorganic solid electrolyte (SE) separators or different SEs and polymer electrolytes (PEs), respectively, are developed to solve the issues of single-electrolyte cells. Among the issues that can be solved are detrimental shuttle effects, decomposition reactions between the electrolyte and the electrodes, and dendrite propagation. However, the introduction of new interfaces by contacting different ionic conductors leads to other problems, which cannot be neglected before commercialization is possible. The interfaces between the different types of ionic conductors (LE/SE and PE/SE) often result in significant charge-transfer resistances, which increase the internal resistance considerably. This review highlights studies evaluating the interfacial resistances and activation barriers in such systems to present an overview of the issues still hampering hybrid battery systems. The interfaces between different SEs in hybrid all-solid-state batteries (SSBs) are considered as well. In addition, a short summary of physicochemical models describing heteroionic interfaces—interfaces between two different ion conductors—is given in an attempt to explain high interface resistances. In doing so, we hope to inspire future work on the crucial topic of interface optimization toward better SSBs.

Graphic Abstract
Epigenetic changes in FOXO3 and CHEK2 genes and their correlation with clinicopathological findings in myelodysplastic syndromes
Authors: Sharifi Mohammad Jafar , Zaker Farhad , Nasiri Nahid , Yaghmaie Marjan 
Published: March 2020

Objectives/background:
Myelodysplastic syndromes (MDSs) are a heterogeneous disease in terms of clinical course and response to therapy. Epigenetic changes are the primary mechanism of MDS pathogenesis. FOXO3 and CHEK2 genes play significant roles in normal cellular mechanisms and are also known as tumor suppressor genes. We aimed to clarify the correlation of epigenetic changes in these genes with clinicopathologic findings in MDS.

Methods:
A total of 54 newly diagnosed MDS patients referred to Shariati and Firouzgar Hospitals (Tehran, Iran) were included in the study from 2013 to 2015, comprising the following cases: 26 with refractory cytopenia with unilineage dysplasia, 10 with refractory cytopenia with multilineage dysplasia, four refractory anemia with excess blasts-1 (RAEB-1), 11 refractory anemia with excess blasts-2 (RAEB-2), and three MDS associated with isolated deletion (5q-). Risk groups were determined according to the Revised International Prognostic Scoring System (IPSS-R). The methylation status of CHEK2 and FOXO3 promoters were determined by methylation-sensitive high-resolution melting analysis of sodium bisulfite-converted DNA. Expressions of CHEK2, FOXO3, and GAPDH were measured by quantitative real-time polymerase chain reaction and fold changes were calculated using the ΔΔCT method.

Results:
Statistical analysis revealed no promoter methylation of CHEK2 and FOXO3 in healthy control specimens. FOXO3 promoter methylation was associated with high-risk World Health Organization subgroups (p = .017), high-risk IPSS-R (p = .007), high-risk cytogenetics (p = .045), and more than 5% blasts in bone marrow (p = .001). CHEK2 promoter methylation was correlated with more than 5% blasts in bone marrow (p = .009).

Conclusions:
Promoter methylation of CHEK2 and especially FOXO3 is associated with adverse clinicopathological findings and disease progression in MDS.