bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Line Treatments for Newly Diagnosed Primary Immune Thrombocytopenia in Children: A Systematic Review and Network Meta-analysis
Authors: Acero-Garcés David O. , García-Perdomo Herney A. 
Published: October 2019

Background:
The first-line interventions in immune thrombocytopenia (ITP) include
intravenous polyclonal immunoglobulins (IVIg), corticosteroids and anti-D immunoglobulin
(anti-D).

Objective:
We aimed to compare the effectiveness and safety of first line treatments for newlydiagnosed
primary ITP in children to increase the platelet count.

Methods:
We searched MEDLINE, EMBASE, LILACS and the Cochrane Central register of Controlled
Trials (CENTRAL); and included the clinical trials. We performed the statistical analysis
in R.

Results:
We included 12 studies for meta-analysis. Compared with IVIG 2g/kg, response rates
were lower for prednisone 2mg/kg at 72 hours [RR 0.04 (95% CI 0.0 to 0.68)] and at 7 days [RR
0.23 (95% CI 0.08 to 0.67)]; at 48 hours, methylprednisolone 30mg/kg also showed lower response
rates [RR 0.72 (95% CI 0.52 to 0.99)]. IVIG 2g/kg and 2.5g/kg had less adverse effects than Anti-
D, methylprednisolone and IVIG 0.8g/kg. For rising platelet count, no statistical differences were
found at 24 hours or in 7 days; at 48 hours, IVIG 2g/kg showed better results than Anti-D 75μg/kg
[MD -58.84 (95% CI -87.02 to -25.66)]. After a month, platelet count with IVIG 2g/kg was higher
than Anti-D 50 and 75μg/kg [-82.03 (95% CI -102.60 to -61.46) and -78.77 (95% CI -97.80 to -
59.74), respectively], but lower than methylprednisolone 50mg/kg [MD 118 (95% CI 3.88 to
232.12)].

Conclusion:
The total platelet count rises higher in early and late phases with IVIG than Anti-D,
but in long term it is higher with methylprednisolone. Additionally, IVIG causes less adverse effects
than Anti-D and corticosteroids.
QSPR Models for the Prediction of Some Thermodynamic Properties of Cycloalkanes Using GA-MLR Method
Authors: Joudaki Daryoush , Shafiei Fatemeh 
Published: October 2019

Aim and Objective:
Cycloalkanes have been largely used in the field of medicine, components
of food, pharmaceutical drugs, and they are mainly used to produce fuel.

In present study the relationship between molecular descriptors and thermodynamic properties such as the standard enthalpies of formation (∆H°f), the standard enthalpies of fusion (∆H°fus), and the standard Gibbs free energy of formation (∆G°f)of the cycloalkanes is represented.

Materials and Methods:
The Genetic Algorithm (GA) and multiple linear regressions (MLR) were
successfully used to predict the thermodynamic properties of cycloalkanes. A large number of molecular
descriptors were obtained with the Dragon program. The Genetic algorithm and backward
method were used to reduce and select suitable descriptors.

Results:
QSPR models were used to delineate the important descriptors responsible for the properties
of the studied cycloalkanes. The multicollinearity and autocorrelation properties of the descriptors
contributed in the models were tested by calculating the Variance Inflation Factor (VIF),
Pearson Correlation Coefficient (PCC) and the Durbin–Watson (DW) statistics. The predictive
powers of the MLR models were discussed using Leave-One-Out Cross-Validation (LOOCV) and
test set validation methods. The statistical parameters of the training, and test sets for GA–MLR
models were calculated.

Conclusion:
The results of the present study indicate that the predictive ability of the models was
satisfactory and molecular descriptors such as: the Functional group counts, Topological indices,
GETAWAY descriptors, Constitutional indices, and molecular properties provide a promising
route for developing highly correlated QSPR models for prediction the studied properties.
Diospyros lotus-mediated Synthesis of Iron Oxide Nanoparticles and Their Application as a Catalyst in Fenton Reaction
Authors: Batool Sadaf , Hussain Zakir 
Published: October 2019

Background: :
Iron Oxide nanoparticles have enormous applications in environmental remediation
and catalysis. The synthesis of such nanoparticles through a green approach provides a
significant advantage due to the non-toxic nature of the ingredients involved.

Method: :
In the present work, Diospyros lotus fruit extract was used for the synthesis of iron oxide
nanoparticles (NPs). The plant biomolecules were extracted employing two different solvents, i.e.
water and methanol. The effect of both the extracts on the reduction of metal salt as well as on the
shape and size of the produced NPs was investigated.

Results::
UV-Visible spectroscopy confirmed the synthesis of iron oxide NPs, Fourier Transform
Infrared (FTIR) spectrum depicted the presence of biomolecules on the surface of NPs as capping
agents, X-ray Diffraction (XRD) diffractogram confirmed the crystalline structure of mixed iron
oxide NPs and Scanning Electron Microscopy (SEM) images showed the spherical shape of NPs.
The synthesized NPs were exploited to catalyze the degradation of methylene blue dye in the Fenton
type catalytic reaction. The degradation reaction was monitored using UV-Visible spectroscopy,
which indicated that the percent degradation increased from 15% (without iron oxide NPs) to 91% in
the presence of organic extract prepared iron oxide NPs and to 81% in the presence of aqueous extract
prepared iron oxide NPs. The effect of the concentration of methylene blue and iron oxide NPs
on the degradation process was also investigated.

Conclusion: :
The results indicated the potential of synthesized nanoparticles to promote catalytic
reactions involved in environmental remediation.
Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients
Authors: El-Nabi Sobhy Hassab , Sayed Samia , Abd-Elhafez Mohamed A. , Elfiky Mohamed , Abdel Moneim Ahmed E. , El-Garawani Islam 
Published: October 2019

Background:
Previous studies have shown that cytomegalovirus (CMV) induced innate
immune response via activation of Toll-like receptor 2 (TLR2). The association between CMV among
specific single-nucleotide polymorphisms (SNPs) in the TLR2 gene was also investigated.

Objective:
This study investigated the relationship between specific SNPs in the TLR2 gene (G>A),
TLR2-Arg753Gln (rs5743708), and CMV replication after bone marrow transplantation.

Methods:
The TLR2-Arg753Gln SNP was genotyped in 181 patients after bone marrow transplantation:
83 and 98 patients with and without CMV infection, respectively. CMV load was determined in
serially collected blood samples using real-time PCR. Genotyping was performed using specific sequence
primer PCR (SSP-PCR), and the results were confirmed by restriction fragment length polymorphism
(RFLP) analysis of the PCR-amplified fragments for GG (wild type), GA and AA identification.

Results:
Roughly, 85% of the patients screened for the presence of the TLR2-Arg753Gln were GG
homozygous, and 15% were GA heterozygous; no patients were homozygous for the mutant allele (A).
The GA heterozygous allele was more frequent in the CMV-infected group after bone marrow transplantation.

Conclusion:
To our knowledge, this is a novel observation that supports the notion that the functional
missense mutation (TLR2-Arg753Gln polymorphism) is possibly associated with CMV replication
after bone marrow transplantation. This suggests a role for TLR2 in the innate immune response of
human CMV infection in Egyptian bone marrow recipients..
Acute Toxicity and Efficacy of Nanomaterial based Decontamination Formulation Developed for Personal Decontamination against Chemical Warfare Agents
Authors: Gautam Anshoo , Prasad Gangavarapu K. , Singh Deeksha , Vijayaraghavan Rajagopalan 
Published: October 2019

Background:
This study addresses the efficacy of nanomaterials based formulation developed for personal decontamination application against chemical warfare agents and used in Personal Decontamination Kit (PDK). It has the potential to decontaminate the skin of an individual, protective equipment, and small arms contaminated with chemical warfare agents. As this formulation has been developed for personal decontamination, risk of nanomaterial toxicity would always be there while sprinkling or applying to the affected area. It may get into the body through various routes specifically through the inhalation route.

Aim:
The aim of this study was to evaluate in vivo decontamination efficiency of the formulation and acute inhalation, intratracheal, intranasal, oral, dermal, and intraperitoneal toxicity of the formulation.

Materials and Methods:
14 days survival was recorded for the evaluation of decontamination efficiency of this formulation. Various endpoints were considered while assessing the toxicity of Nanomaterial Decontamination Formulation which include Organ Body Weight Index (OBWI), serum biochemical parameters, and respiratory variables like tidal volume, respiratory rate, time of inspiration, time of expiration, etc. LD50 of the formulation were also determined for various routes. As skin is the primary organ to come in contact with the decontaminant, its primary skin irritation response has also been determined in this study.

Results and Conclusion:
It was found that there is no gross acute toxicity observed at different doses. Though there were some changes in the initial respiratory pattern, they were all later recovered. The preliminary histological evaluation did not show any adverse effect on various organs after exposure with NDF.
Recent Advances and Current Developments of Molten Pool Temperature Measurement for Laser Additive Manufacturing Processes
Authors: Liu Zhichao , Li Tao , Kim Hoyeol , Cong Weilong , Jiang Qiuhong , Zhang Hong-Chao 
Published: October 2019

Background:
Molten pool temperature in Laser Additive Manufacturing (LAM) will affect
powder efficiency, structural compositions of reactants and products in the molten pool, thus determining
the microstructure evolutions and mechanical properties of the final part. An interest in molten pool
temperature measurement has been around for a long time since the appearance of LAM. However, a
comprehensive summary of the existing methods and their applications does not exist in the literature.

Objective:
The state-of-the-art of the existed devices and methods for molten pool temperature measurement
in various of LAM processes is reviewed in this paper.

Methods:
The existing temperature measurement methods for molten pool monitoring in LAM processes
are discussed. For each method, the existed patents, detailed procedures, advantages and disadvantages,
specific applications are specified. In the end, comparisons among the current temperature
measurement techniques are made according to data accuracy, operation complexity and cost of implementation.

Results:
Four methods are currently being used for the molten pool temperature measurement in LAM
processes, including (i) Thermocouples, (ii) Infrared pyrometers, (iii) Infrared cameras, and (iv)
Charge-coupled-device cameras.

Conclusion:
Different measurement methods represent different characteristics of the signal, and each
has merits and defects. Selecting suitable measurement method according to different process characteristics
will be helpful to achieve a preferable and more convincing results.
LA INSERCIÓN COMERCIAL DE CHINA EN LATINOAMÉRICA
Authors: López Arévalo Jorge Alberto , Rodil Marzábal Óscar 
Published: October 2019

<p>Este trabajo estudia los intercambios bilaterales de China con México, Chile, Costa Rica y Perú desde la óptica del comercio intraindustrial durante 1995-2017. En particular, se analizan las diferencias en el patrón de inserción intraindustrial en un contexto marcado por la existencia (Chile, Costa Rica y Perú) o no (México) de acuerdos de libre comercio con China. El estudio se completa con un análisis econométrico (efectos fijos) de los determinantes del comercio intraindustrial. Los resultados muestran una inserción de bajo perfil intraindustrial, con la excepción de algunas partidas específicas relativas a productos eléctricos y de la industria automotriz. Por otro lado, se confirma el efecto positivo del tamaño de la economía, de la inversión extranjera directa y de la diferenciación de producto, así como negativo de la diferencia en el nivel de ingreso; mientras que existe una indefinición en el papel de los acuerdos de libre comercio con China.<br /><br /></p><p>THE TRADE INTEGRATION OF CHINA IN LATIN AMERICA</p><p> </p><p><strong>ABSTRACT</strong><br />This paper studies China’s bilateral trade with Mexico, Chile, Costa Rica and Peru from the perspective of intra-industrial trade during 1995-2017. In particular, the differences in the pattern of intra-industrial insertion are analyzed in a context characterized by the existence (Chile, Costa Rica and Peru) or not (Mexico) of free trade agreements with China. An econometric analysis (fixed effects) of the determinants of intra-industrial trade completes the study. The results show a low intra-industrial profile, except for some specific items related to electrical products and the automotive industry. The positive effect of the size of the economy, foreign direct investment and product differentiation is also confirmed, as well as the negative effect of the difference in income level. However, there is an undefined role for free trade agreements with China.</p>
Scenarios for small and medium enterprises provisions in USMCA renegotiation. A critical analysis of challenges and opportunities
Authors: Vargas Hernández José G. , López Lemus Jorge Armando 
Published: October 2019

The objective of this document is to establish some scenarios for small and medium enterprises (SMEs) based on a critical analysis of the provisions in the renegotiation of the United States-Mexico-Canada Agreement (USMCA), its challenges and opportunities. The critical analysis starts from the questionable position of USMCA’s withdrawal and its consequences for SMEs of not giving continuity through a renegotiation process between the three partners. Based on some sources of information, the study of the results of the North American Free Trade Agreement (NAFTA) and the USMCA, and the strategic review of their challenges and opportunities for SMEs, some possible scenarios are established after the renegotiation of the USMCA, as well as some strategic proposals for SMEs.
The Profesionalism Improvements of Catholic Religious Teachers in Jember
Authors: Sutadi Petrus Amat , Widagdo Suwognyo , Dimyati Muhaimin 
Published: October 2019

The quality of teacher, one that can be seen from the professionalism of the teacher. The professionalism of the Catholic religious teachers in Jember can be measured from four factors, such as: trainings, teaching experience, school facilities and the quality of supervisions. Based on the explanation above, the formulation of the problem in teaching, teaching experience, school facilities and the quality of supervision in improving the professionalism of the Catholic religious teachers in Jember. This study aims to examine whether there are influences from trainings, teaching experience, school facilities and quality of supervision in improving the professionalism of the Catholic religious teachers in Jember. The population of this study was Catholic religious teachers in Jember. In this study, researchers will use total sampling. In this study, the researcher sample samples of 30 Catholic religious teachers as respondents, because this study uses multiple linear regression analysis of SPSS version 16 application. Based on data analysis shows that the training has a dominantly significant effect on the professionalism of the improvement of Catholic religious teachers in Jember. Whereas teaching experience, school facilities and infrastructures. and quality of supervision gives a not-yet-dominantly effective improvement to the professionalism of Catholic religious teachers in Jember.
REKAYASA DAN MANUFAKTUR KOMPOSIT SANDWICH HIBRID UNTUK PANEL
Authors: Hariyanto Agus 
Published: October 2019

Tujuan penelitian ini adalah menyelidiki pengaruh fraksi volume core terhadap peningkatan kekuatan Impak komposit sandwich hibrid berpenguat kombinasi serat rami woven dan serat gelas woven bermatrix polyester dengan core berpenguat kombinasi serbuk kayu jati dan mahoni bermatrix polyester. Mekanisme perpatahan diamati dengan foto makro.Bahan yang digunakan untuk skin adalah serat rami (woven), serat E-Glass (woven), resin unsaturated polyester 157 BQTN (UPRs). Bahan yang digunakan untuk core adalah serbuk kayu jati dan mahoni dengan mesh 30 pada fraksi volume 30%, 40%, dan 50%, resin unsaturated polyester 157 BQTN. Hardener yang digunakan adalah MEKPO dengan konsentrasi 1%. Komposit dibuat dengan metode cetak tekan. Komposit sandwich hibrid tersusun terdiri dari dua skin komposit hibrid dengan core hibrid ditengahnya. Skin komposit hibrid sebagai lamina terdiri dari dua lamina serat gelas anyam dan satu lamina serat rami (woven - woven – woven). Fraksi volume serat komposit skin hibrid adalah 30%. Komposit core hibrid yang digunakan adalah serbuk kayu jati dan mahoni dengan mesh 30 pada fraksi volume 30%, 40%, dan 50% dengan resin unsaturated polyester 157 BQTN. Variabel utama penelitian yaitu fraksi volume core (30%, 40%, dan 50%). Spesimen dan prosedur pengujian Impak mengacu pada standard ASTM D 5942. Hasil penelitian menunjukkan bahwa penambahan fraksi volume core mampu meningkatkan energi serap dan kekuatan impak komposit sandwich hibrid. Mekanisme patahan diawali oleh kegagalan komposit skin bagian tarik, core gagal geser, dan diakhiri oleh kegagalan skin sisi tekan. Pada bagian daerah batas core dan komposit skin menunjukkan adanya kegagalan delaminasi.
Digital Escape Game
Authors: Clune Megan Lea 
Published: October 2019

The Escape Room phenomena began in Japan in 2007. The premise of an Escape Room is that ‘players’ are locked inside a room and, in order to escape, they must solve a range of puzzles, riddles, and open mechanisms and locks inside a given timeframe. While the educational affordances of an escape room have been and continue to be explored (see for example Brown, Darby & Coronel, 2019) the grandeur and physical complexities required to set up an escape room mean than it is not a sustainable option for the average classroom teacher or smaller tertiary courses.
The Escape Game, however, is played on a smaller scale with portable (often mostly printable) resources with players aiming to either break into something (a toolbox for example) by solving riddles, puzzles and opening locks within a given timeframe. The logistical ease of set up and iterability mean that the escape game format is becoming increasingly popular across all sectors of education—from young primary school learners to tertiary tauira (see for example Yachin, & Barak, 2019).
A successful example of the escape game movement in education is Breakout EDU (see for example Detwiler, Jacobson, & O’Brien, 2018). In addition to being a platform that provides resources to create your own and use other educator-made physical breakout games, Breakout EDU also provide members with a digital escape game creator and online repository. It was the Breakout EDU digital game format that was used as the mediating artefact in this case study.
A digital escape game, Mathematical Medley, was created for educators undertaking a postgraduate mathematics education course. The game was embedded into the course’s learning management system and activated at a certain time point for tauira to complete in groups or individually (as they chose). The purpose of the study was to explore how a digital escape game might promote the learning of mathematical content (subject knowledge); and how a digital escape game might enable the use and development of key competencies and mathematical processes. An overview of the escape game, purpose, findings and implications of using the mediating artefact will be shared during the presentation of this case study.
Integrasi Pendidikan Karakter Melalui Pendekatan Kontekstual Dalam Mata Kuliah Profesi Pendidikan Terhadap IQ Dengan Mengendalikan EQ dan SQ Mahasiswa
Authors: Manu Theodora Sarlotha Nirmala , Meha Agus Maramba 
Published: October 2019

This research aims to examine whether there is an influence of self-confidence in students' motivation to achievement in science lesson in elementary schools. This is a field research, where the researchers are involved directly down to the place of research to collect the data relevant to the indicators in the research objectives, which classifies this as a field research with a correlational quantitative approach. Correlational quantitative research is research to determine the level of relations between two or more variables, without making changes, additions, or manipulations of data that already exists. The data analysis techniques was done by observations and questionnaires instruments. Based on the results of analysis with manual calculations, the R Square correlation coefficient is 0.39 or 39% which means that self-confidence affects student motivation for achievement, while the rest is influenced by other variables of 61% that were not examined. This indicates that the variations of confidence with motivation of achievement is 39%. Based on the calculation, the tcount valued 2.898> from ttable, with dk=48, worth 2.011 which means there is an influence of confidence (X) to motivation for achievement (Y). The hypothesis for Ha is accepted and Ho is rejected.
Preliminary Phitochemical Analysis Of Guava Leaves (Psidium guajava L.) Extract As Antidiarrheal In Calves
Authors: Sudira I Wayan , Merdana I Made , Qurani Suci Nur 
Published: October 2019

Guava plants (Psidium guajava L) are fruit plants originating from South America and can thrive in the territory of Indonesia. Now the biggest center for guava cultivation is spread in DKI Jakarta, West Java, Central Java, East Java, Yogyakarta, Bali, West Nusa Tenggara, Sumatra and Kalimantan. In addition to taking the fruit, guava leaves are also used as a traditional medicine for the treatment of diarrhea in human and animals. This study aims to identify active compounds in guava leaves. That is a secondary metabolites with pharmacological effects as anti diarrhea such as flavonoid, alkaloid, tannins and essential oils. The leaves sample used in this study were taken from farmers in the West Denpasar area, Bali. Extraction of guava leaf leaves using 96% ethanol, and phytochemical analysis was carried out to detect the presence of active compounds. The data obtained is presented and analyzed descriptively qualitatively. The results showed that the ethanol extract of guava leaves contained active compound inclaude steroid/triterpenoid, phenolics, alkaloids, flavonoids, saponins and tannins. It can be concluded that guava leaf extract contains are potential antidiarrheal