bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute compartment syndrome of the lower limb following childbirth: a case report
Authors: Coulton Sharon , Bourne Sally , Catliffe Simon , Brooks Roderick , Jollow David 
Published: September 2020

Abstract
Background
Acute compartment syndrome is a limb-threatening and occasionally life-threatening emergency that is rarely reported as a complication following childbirth. Prompt diagnosis is crucial to avoid permanent functional restriction or even the loss of the affected limb. Clinical signs and symptoms might be nonspecific, especially in the early stages; therefore, knowledge of predisposing risk factors and signs and symptoms of acute compartment syndrome is necessary to prevent long-term complications and amputation.

Case presentation
This paper presents a case of a 26-year-old primiparous Sri Lankan woman who developed acute compartment syndrome of the lower right limb following childbirth by cesarean section.

Conclusion
Acute compartment syndrome is an important differential diagnosis in the setting of sudden onset of lower limb pain following childbirth. Predisposing factors for its manifestation within an obstetric environment are augmented labor, the lithotomy position, postpartum hemorrhage, hypotension following epidural analgesia, and the use of vasoconstrictive agents. If left undiagnosed and untreated, acute compartment syndrome may cause permanent neurovascular deficit, leading to a poor functional result, tissue ischemia, limb amputation, and rhabdomyolysis. If severe, and in large compartments, it can lead to renal failure and death. Alertness and a high index of clinical suspicion for the possibility of acute compartment syndrome are required to avoid a delay in diagnosis, and intracompartmental pressure measurement can be used to confirm the diagnosis.
Ribosomal protein L34 is a potential prognostic biomarker and therapeutic target in hilar cholangiocarcinoma
Authors: Qian Jianxin , Xu Lin , Yu Wenlong , Gu Xiaoqiang , Zuo Yongjun , Chen Ying , Xie Feng , Wei Lixin 
Published: September 2020

Abstract
Background
Ribosomal protein 34 (RPL34) is a highly conserved protein belonging to the 60S large subunit of mammalian ribosomes that has been found to be dysregulated in a variety of human tumors. However, there are limited results that illuminate the role and expression profiles of RPL34 in hilar cholangiocarcinoma (HCCA).

Methods
RPL34 expression was detected in human HCCA by immunohistochemistry. The relationship of RPL34 expression with clinical outcomes was evaluated by univariate and multivariate analyses. The effect of RPL34 on cell migration and tumor growth was detected after silencing endogenous RPL34 expression.

Results
RPL34 was overexpressed in HCCA compared with normal tissue samples and correlated significantly with regional lymph node metastasis and poorly/undifferentiated tumors. Patients with high RPL34 expression had a shorter time to recur and a poorer outcome than those without RPL34 expression. Silencing RPL34 inhibited cell proliferation and migration in vitro and upregulated E-cadherin. Silencing RPL34 also attenuated tumor growth in vivo.

Conclusions
Our findings suggested that RPL34 might serve as a promising prognostic biomarker and a potential therapeutic target for the treatment of HCCA.
Thematic areas and complexity of integrated community case management (iCCM) design, implementation, and evaluation: protocol for a scoping review
Authors: Karim Aliya , Cobos Muñoz Daniel , Mäusezahl Daniel , de Savigny Don 
Published: September 2020

Abstract
Background
Integrated community case management (iCCM) is a community-based child health strategy designed to reduce deaths due to pneumonia, malaria, and diarrhea in low-income countries. Due to the integrated nature of the intervention and the diversity of its stakeholders and activities, iCCM is complex and comprises many systems elements. However, the extent to which studies examine these different elements is unknown. The purpose of this scoping review is to summarize the key areas of emphasis of the iCCM literature and assess the extent to which this takes into account systems complexity.

Methods
This study will be guided by Arksey and O’Malley’s scoping review methodology. We will systematically screen MEDLINE, Web of Science, and the specialized platform Community Case Management (CCM) Central Library for published literature in English related to the design, implementation, and evaluation of iCCM. Two investigators will independently screen the full list of titles and abstracts for eligibility, followed by a full-text review of selected titles divided between investigators. Emergent themes will be categorized according to a thematic tool iteratively developed to guide the charting and analysis process. To compare the extent to which the literature assesses systems factors, we will compare our results with the iCCM Interagency Framework. We will use the Intervention Complexity Tool for Systematic Reviews (iCAT_SR) to assess how literature measures complexity. Results will be presented in narrative fashion, supplemented by interactive graphical interfaces.

Discussion
The results of this scoping review will identify the priorities and deficiencies of the analysis and evaluation of iCCM programs and may illustrate the need for systems approaches. Bottom-up emergent iCCM themes can help researchers, policymakers, and implementers target and better emphasize true priorities of iCCM. Understanding how complexity is considered and examined in iCCM may result in greater attention to this critical dimension of iCCM program assessment, resulting in the design and development of more robust and sustainable iCCM programs.
Asymptotics for $L_{1}$-wavelet method for nonparametric regression
Authors: Zhou Xingcai , Zhu Fangxia 
Published: September 2020

AbstractWavelets are particularly useful because of their natural adaptive ability to characterize data with intrinsically local properties. When the data contain outliers or come from a population with a heavy-tailed distribution,$L_{1}$L1-estimation should obtain a better fit. In this paper, we propose a$L_{1}$L1-wavelet method for nonparametric regression, and derive the asymptotic properties of the$L_{1}$L1-wavelet estimator, including the Bahadur representation, the rate of convergence and asymptotic normality. The rate of convergence of it is comparable with the optimal convergence rate of the nonparametric estimation in nonparametric models, and it does not require the continuously differentiable conditions of a nonparametric function.
Preventive effect of Lactobacillus plantarum HFY09 on HCl/ethanol-induced gastric injury in mice
Authors: Li Fang , Sun Hailan , Ran Guangjun , Liu Xinhong , Yi Ruokun , Tan Fang , Zhao Xin , Liu Huazhi 
Published: September 2020

AbstractThe aim of this study was to investigate the effect of Lactobacillus plantarum HFY09 on gastric injury induced by HCl/ethanol in Kunming mice. The results showed that HFY09-H inhibited any increases in gastric juice volume, maintained the normal pH value of gastric acid, and reduced the damage caused to the gastric mucosa and gastric wall, the inhibition rate on the injury area reaches 63.70%. Compared with the negative control group, HFY09 increased the levels of serum somatostatin (SS) and vasoactive intestinal peptide (VIP), and also decreased the levels of substance P (SP), endothelin-1 (ET-1), interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). In addition, real time fluorescent quantitative PCR (Q-PCR) also confirmed that high-dose HFY09 (109 CFU/kg/day) upregulated the mRNA expression of copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), catalase (CAT), endothelial nitric oxide synthase (eNOS), and neuronal nitric oxide synthase (nNOS), and downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). At the same time, the results of the HFY09 treatment group were similar to those of the ranitidine treatment group. These results indicate that HFY09 can prevent gastric injury induced by HCl/ethanol in vivo. Therefore, HFY09 may play a potential role in the treatment of gastric diseases.
Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment
Authors: Kang Mi Ju , Gong Jeong Eun , Kim Ji Eun , Choi Hyeon Jun , Bae Su Ji , Choi Yun Ju , Lee Su Jin , Seo Min-Soo , Kim Kil Soo , Jung Young-Suk , Cho Joon-Yong , Lim Yong , Hwang Dae Youn 
Published: September 2020

AbstractDifferences in responsiveness of BALB/c substrains have been investigated in various fields, including diabetes induction, corpus callosum deficiency, virus-induced demyelinating disease, aggressive behavior and osteonecrosis. However, induction efficacy of skin tumor remains untried. We therefore investigated the influence of BALB/c substrain backgrounds on the skin tumor induction efficacy in response to DMBA (7,12-Dimethylbenz[a]anthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate) cotreatment. Alterations in the levels of tumor growth related factors, histopathological structure, and the expression to tumor related proteins were measured in three BALB/c substrains (BALB/cKorl, BALB/cA and BALB/cB) after exposure to DMBA (25 μg/kg) and three different doses of TPA (2, 4 and 8 μg/kg). The average number and induction efficacy of tumors in response to DMBA+TPA treatment were significantly greater in the BALB/cKorl substrain than in BALB/cA and BALB/cB. However, cotreatment with DMBA+TPA induced similar responses for body and organ weights of all three substrains. Few differences were detected in the serum analyzing factors, while similar responsiveness was observed for blood analyzing factors after DMBA+TPA treatment. Furthermore, the three BALB/c substrains exhibited similar patterns in their histopathological structure in DMBA+TPA-induced tumors. The expression levels of apoptotic proteins and tumor related proteins were constantly maintained in all three BALB/c substrains treated with DMBA+TPA. In addition, the responsiveness to cisplatin treatment was overall very similar in the three BALB/c substrains with DMBA+TPA-induced tumors. Taken together, these results indicate that genetic background of the three BALB/c substrains does not have a major effect on the DMBA+TPA-induced skin carcinogenesis and therapeutic responsiveness of cisplatin, except induction efficacy.
Does COVID-19 pose a challenge to the diagnoses of anxiety and depression? A psychologist's view
Authors: Johnstone Lucy 
Published: September 2020

SummaryThe COVID-19 pandemic has led to predictions of a widespread mental health crisis. However, this makes little sense when fear and anxiety are so understandable in context. The individualisation and medicalisation of normal human reactions disconnects us from our feelings and from the appropriate solutions, in relation to the pandemic and more generally. We have an opportunity to challenge this pervasive way of thinking, and thus be in a position to create a fairer society that is better for everyone's emotional well-being.
Gap junctions: historical discoveries and new findings in the C
aenorhabditis
elegans nervous system
Authors: Jin Eugene Jennifer , Park Seungmee , Lyu Xiaohui , Jin Yishi 
Published: September 2020

ABSTRACT
Gap junctions are evolutionarily conserved structures at close membrane contacts between two cells. In the nervous system, they mediate rapid, often bi-directional, transmission of signals through channels called innexins in invertebrates and connexins in vertebrates. Connectomic studies from Caenorhabditis elegans have uncovered a vast number of gap junctions present in the nervous system and non-neuronal tissues. The genome also has 25 innexin genes that are expressed in spatial and temporal dynamic pattern. Recent findings have begun to reveal novel roles of innexins in the regulation of multiple processes during formation and function of neural circuits both in normal conditions and under stress. Here, we highlight the diverse roles of gap junctions and innexins in the C. elegans nervous system. These findings contribute to fundamental understanding of gap junctions in all animals.
Crise econômica e política neoliberal no Sistema Nacional de Saúde Espanhol
Authors: Aguilar Gil Marta , Bleda García José María 
Published: September 2020

A globalização econômica e o avanço das políticas neoliberais no mundo, juntamente com a privatização dos serviços de saúde e o conflito entre recursos e gastos disponíveis, levou a novos questionamentos sobre a manutenção do estado de bem-estar. Os objetivos da pesquisa foram: identificar as consequências que resultaram na crise econômica internacional desencadeada em 2007-2008 e as políticas neoliberais no sistema de saúde espanhol de 2013 até o presente; conhecer a situação existente; e fazer uma proposta de melhorias. Supunha-se que o corte no orçamento aplicado como resultado da crise econômica global e nacional pudesse ter sido decisivo na desconstrução do sistema e no aumento dos serviços privados de saúde. Utilizou-se uma análise documental dos estudos e relatórios realizados por experts, bem como de diferentes organizações públicas e privadas relacionadas ao setor. Os resultados destacam o bom estado de saúde do Sistema Nacional de Salud embora seja necessário abordar uma série de reformas (financiamento, planejamento, profissionais, política de medicamentos ou sistemas de informação, entre outros), e a inexorável necessidade de um pacto estadual para a saúde
MAIN INDICATORS OF THE NEUROLOGICAL PROFILE BED FUND OF ROUND-THE-CLOCK AND DAILY STAY HOSPITALS IN THE RUSSIAN FEDERATION AND ITS REGIONS
Authors: Mel'nikov Yuriy , Bant'eva M. , Manoshkina E. 
Published: September 2020

In the Russian Federation the process of reduction of the round-the-clock bed fund with the simultaneous development of hospital-replacing technologies has been going on for more than twenty-five years, as well as, in most developed countries of the world, in recent decades.From 2010 to 2018 the absolute number of neurological round-the-clock hospital beds in the Russian Federation, as well as hospital beds of most other profiles, has significantly decreased: from 73754 to 64116 (by 13.1%), as well decreased the hospitalization rate (from 12.6 to 12.2 per 1000 population — by 3.2%) and the provision of these beds (from 5.16 to 4.37 per 10,000 population — by 15.3%), the average length of stay in a neurological bed (from 13.7 to 11.3 days — by 17.5%) and its average occupancy per year (341 to 328 days — by 3.8%). In 2018, the extreme values of the indicator of the provision of the population with hospital beds of the neurological profile of round-the-clock stay in the regions of the Russian Federation differed 2.5 times, what indicates the imbalance in the structural transformations of the hospital bed fund in the regions of the Russian Federation. Mortality in neurological hospital beds in the Russian Federation increased from 3.77% in 2010 to 4.17% in 2018 (by 10.6%).Thus, it is possible to conclude that a hospital-replacing function takes place in the country and there has been a redistribution of the volume of neurological care from the round-the-clock hospital beds to daily stay hospital beds, however, the bed fund of both round-the-clock and daily stay hospitals is characterized by extreme disproportionality of development in the regions of the Russian Federation, what may indicate an imbalance in structural-functional transformations, what should be carried out taking into account the characteristics of each particular region.
Dual subaperture stitching for large flat mirror testing
Authors: Kim Goeun , Song In-Ung , Gyu Park June , Kihm Hagyong , Yang Ho-Soon 
Published: September 2020

The Ritchey–Common test is a widely used method for testing flat mirrors with a larger reference spherical mirror. However, with the increase in the size of the flat mirror, the fabrication of the spherical mirror becomes more time consuming and expensive. In this study, we developed a novel technique to test a large flat mirror with a smaller reference sphere using a dual subaperture stitching (DSS) method. One part of the DSS technique is a modified Ritchey–Common test, which uses a reference sphere smaller than the flat mirror. The other part involves scanning along the centerline of the flat mirror. The former can be used to determine the surface form error (SFE), except for rotationally symmetric components, such as power and spherical aberrations, which can be measured by the latter. To perform the stitching process using a smaller reference sphere, the flat mirror was repeatedly rotated by a fixed angular step. One of the advantages of the rotation of the flat mirror is that it can be used to identify the errors resulting from the reference sphere, which do not vary during the rotation of the flat mirror. We verified the DSS method using a 152 mm diameter optical flat mirror and determined the root-mean-square (rms) measurement error to be only 0.2 nm, which was comparable to the error of the full-aperture interferometric measurement. In addition, we tested a 1.2 m diameter flat mirror with a reference sphere with an aperture of 0.8 m and measured its SFE to be

11.9

±

0.5

n
m

rms.
Reflexões sobre a taxeonomia toponímica
Authors: Lucas Patricia , Seide Márcia Sipavicius 
Published: September 2020

Tradicionalmente, os estudos toponomásticos sempre estiveram embasados na teoria criada por Maria Vicentina do Amaral Dick, proposta no inicio da década de 1992 e depois ampliada por Aparecida Negri Isquerdo em 1996. A taxeonomia proposta por Dick (1992) considera as características dos topônimos em análise e os categoriza em taxes toponímicas, sendo essas subdividas em motivações antropoculturais ou físicas. Contudo devido a complexidade, a dinamicidade e a singularidade existente no ato de nomear um lugar, novas metodologias para análise toponimica em consonância com as taxes existentes devem ser consideradas, afim de ampliar as reflexões no âmbito dos estudos toponomásticos. Nesta perspectiva este estudo propõe refletir sobre a abordagem taxeonomica dos topônimos .Para tanto será apresentado um recorte da dissertação de mestrado “Os nomes comerciais de Naranjal- Paraguai”, em que Lucas (2019) estudou os nomes dos estabelecimentos comerciais da cidade paraguaia partindo da taxeonomia toponímica para outras áreas dos estudos linguísticos. Os resultados obtidos evidenciaram que a análise dos topônimos a partir da taxeonomia toponímica conciliada com outras áreas dos estudos linguísticos permite ao pesquisador realizar reflexões que transcendem o campo das motivações toponímicas e contribuem significativamente para a história, cultura e memória linguistica e cultural da comunidade investigada.
Peningkatan Perilaku Anti Korupsi Melalui Metode Story Telling
Authors: Lestari Dwi Puji 
Published: September 2020

The purpose of this research was to determinate the proccess of implementation of story telling metode to increase behavior of anti-corruption in Group B Az Zahra Kebayoran Baru South of Jakarta. This research is an action research which refers to the model of a classroom Action Research Kemmis and Mc. Taggart. The subject of this research are children in Group B Az Zahra Kebayoran Baru South of Jakarta there are 16 children, who consist of 6 girls and 10 boys. The steps of this research : 1) Planing (2) Action (3) Observation (4) Reflection. Data analysis used quantitative and qualitative. Data analysis qualitative used Miles and Hubberman model. This research do in two cycles, there are cycle I and II. The end result of the overall analysis of the data is the percentage in 88,05% cycles II which showed from pre-cycle is 41,23% up to cycles I 72,32%
Pengembangan Karakter Pada Anak Usia Dini (AUD)
Authors: Rohmah Umi 
Published: September 2020

Abstract
Qualified characters need to be established and nurtured from an early age. Early age is a critical period for the formation of one's character. The character of early childhood is influenced by two factors, namely internal and external. Early childhood has distinctive characteristics, physically, psychologically, socially, morally, and so on. Character development in school will be done smoothly, if the teacher in its implementation pay attention to some principles of character development. Character is developed through stages: knowledge (knowing), execution (acting), and habit (habit). There are several challenges that become the main problem in character development in the global era.
There are some effective tips on developing early childhood characters in the school that can be offered, including: 1) involving the moral aspects of knowing, moral feeling, and moral action, 2) reviving sunnah Dhuha prayers together, 3) kissing the hands of teachers, 4) tell the biography of the characters (5) holding regular prayers and istighosah, 6) teachers, staff, and principals should be role models for children, 7) working with parents, 8) providing rewards and sanctions, etc. The successful development of character in early childhood education can be known from everyday behaviors that appear in every child's activity.
Keywords: character development, early childhood
Gamelan Bocah (GACAH): Penumbuhan Karakter Kebangsaan di TK Sari Asih Yogyakarta
Authors: Pamungkas Joko , Syamsudin Amir , Harun Harun 
Published: September 2020

This study aims to describe the children gamelan media in fostering national character values such as tolerance, responsibility, independence, adaptation, courtesy and discipline, and finalize the achievements of gross motoric development, fine motor skills, cognitive, and the early childhood art. This research method uses quasi-experiment. The variables consisted of playing children gamelan, children development, and national character values. The subjects were 16 students aged 4-6 years of Sari Asih Kindergarten, Catur Tunggal, Depok, Sleman, Yogyakarta. This research starts from learning using children gamelan media and observing children national character behavior as well as the achievements of the children development. Data collection techniques use observation sheets for national character behavior and unstructured interview guidelines. The data analysis technique uses descriptive-qualitative. The results showed that playing children gamelan can accelerate the stimulation of the values of tolerant, responsible, and children independent characters, and can finalize the achievement of gross and cognitive motor development.
FUTURE PERSPECTIVE AND WORK READINESS ON STUDENTS
Authors: Ridho Ali , Siswanti Ariska Dwi 
Published: September 2020

This study aims to prove that the future perspective (FP) can be a good predictor of work readiness (WR) among college students. This study used the correlational method. A total of 90 eighth semester students (60 male, 30 female) from the Faculty of Science and Technology, Psychology, and Tarbiyah of the Universitas Islam Negeri Maulana Malik Ibrahim Malang became participants in this study. Participants' age ranged between 21-25 years (M = 23.7 years). This study used the adaptation of future perspective (FP) instruments from Husman and Shell (2008), which consists of 15 items, with α = 0.830, and the work-readiness adaptation instrument from Cabellero et al. (2011), which consists of 16 items, with α = 0.849. The researcher analyzed the data with bivariate linear regression. The study suggested a regression coefficient of B = 0.413 with t (89) = 5.314 p <0.01, r (88) = 0.493 p <0.01, and R2 = 0.243. These results indicate that FP has a strong relationship with WR, and FP can be a good predictor for WR. Therefore it can be concluded that FP supports the work readiness of students. This study suggests that students should be courageous in choosing meaningful activities to create a strong connection between the performed activities and the proposed career.