bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: Preliminary evidence in adolescents with treatment-resistant depression
Authors: Roy Abhrajeet V , Thai Michelle , Klimes-Dougan Bonnie , Westlund Schreiner Mindy , Mueller Bryon A , Albott Christina Sophia , Lim Kelvin O , Fiecas Mark , Tye Susannah J , Cullen Kathryn R 
Published: July 2020

Background: Current theory suggests that treatment-resistant depression (TRD) involves impaired neuroplasticity resulting in cognitive and neural rigidity, and that clinical improvement may require increasing brain flexibility and adaptability. Aims: In this hypothesis-generating study, we sought to identify preliminary evidence of brain flexibility correlates of clinical change within the context of an open-label ketamine trial in adolescents with TRD, focusing on two promising candidate markers of neural flexibility: (a) entropy of resting-state functional magnetic resonance imaging (fMRI) signals; and (b) insulin-stimulated phosphorylation of mammalian target of rapamycin (mTOR) and glycogen synthase-3-beta (GSK3β) in peripheral blood mononuclear cells. Methods: We collected resting-state functional magnetic resonance imaging data and blood samples from 13 adolescents with TRD before and after a series of six ketamine infusions over 2 weeks. Usable pre/post ketamine data were available from 11 adolescents for imaging and from 10 adolescents for molecular signaling. We examined correlations between treatment response and changes in the central and peripheral flexibility markers. Results: Depression reduction correlated with increased nucleus accumbens entropy. Follow-up analyses suggested that physiological changes were associated with treatment response. In contrast to treatment non-responders ( n=6), responders ( n=5) showed greater increase in nucleus accumbens entropy after ketamine, together with greater post-treatment insulin/mTOR/GSK3β signaling. Conclusions: These data provide preliminary evidence that changes in neural flexibility may underlie symptom relief in adolescents with TRD following ketamine. Future research with adequately powered samples is needed to confirm resting-state entropy and insulin-stimulated mTOR and GSK3β as brain flexibility markers and candidate targets for future clinical trials. Clinical trial name: Ketamine in adolescents with treatment-resistant depression URL: https://clinicaltrials.gov/ct2/show/NCT02078817 Registration number: NCT02078817
Correlation between monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 and coronary plaque characteristics
Authors: Li Meng , Chen Yan , Zhang Yan , Li Danna , Liu Jun 
Published: July 2020

In this work, our primary objective was to examine the interrelationship among the serum level of chemokine (C-C motif) ligand 2 (CCL2) and plaque characteristics in coronary culprit lesions. The clinical data of 116 coronary heart disease patients who were hospitalized in the Department of Cardiology of Henan Province People's Hospital from February 2015 to June 2017 were retrospectively analyzed. The study population was subdivided according to the concentration of CCL2 into low CCL2 group and high CCL2 group. The levels of blood lipid, creatinine, and uric acid were measured, and patients underwent coronary angiography. The characteristics of the culprit lesions were detected by intravascular ultrasound, and the correlation between the serum markers and the characteristics of coronary artery plaque was analyzed. Moreover, the coronary artery disease dataset from the Gene Expression Omnibus database was downloaded and the genes regulated were analyzed by CCL2 using gene set enrichment analysis (GSEA). Patients with high CCL2 group had higher LDL-C level and L/H ratio, and lower HDL-C level than the low CCL2 group. Compared with low-level CCL2 group, coronary plaque in the high CCL2 group had higher eccentric plaque and plaque rupture, and thin cap fibroatheromas, fibrofatty and necrotic core and lower fibrous tissue. CCL2 was positively correlated with the percentage of fibrofatty and necrotic core, and negatively correlated with the percentage of fibrous tissue. Furthermore, GSEA analysis showed that samples with high CCL2 expression were enriched for genes involved in different pathways, such as cell adhesion molecules and Nod-like receptor signaling pathway. The CCL2 level was correlated with vulnerable plaques of coronary artery and had certain value in detecting vulnerable plaques. These results indicated that CCL2 could be regarded as a clinical prognostic biomarker for coronary artery disease. Impact statement Vulnerable plaques are plaques which are susceptible to rupture or thrombosis and trigger a series of adverse events such as coronary disorders. CCL2 is a soluble basic protein belonging to the CC subfamily. Previous studies have been investigated on the correlation between inflammatory factors and clinical events, but there are few studies on the correlation between CCL2 and plaque characteristics. Our study found that the high expression of CCL2 is involved in multiple processes in the genesis and progression of coronary artery disease, and would be a potential clinical prognostic indicator. In addition, high expression of CCL2 may be related to gene pathways such as Nod-like receptor signaling pathway, suggesting that CCL2 is involved in the inflammatory response and immune process of coronary artery disease.
Safety and efficacy of transitioning from the combination of bosentan and sildenafil to alternative therapy in patients with pulmonary arterial hypertension
Authors: Verlinden Nathan J. , Benza Raymond L. , Raina Amresh 
Published: July 2020

The combination of bosentan and sildenafil is commonly used to treat patients with pulmonary arterial hypertension (PAH); however, there is evidence of a significant drug interaction between these two medications. We sought to evaluate the safety and efficacy of transitioning patients with PAH from the combination of bosentan and sildenafil to alternative therapy. A retrospective database review was performed on 16 patients with PAH who were treated with the combination of bosentan and sildenafil and transitioned to alternative treatment at our center. Invasive and non‐invasive patient parameters were collected at baseline and after transition. 56.3% of patients were in World Health Organization functional class (WHO FC) III and a majority of patients (68.7%) were on background prostacyclin therapy. The most common reason for transition was concern for a drug interaction in seven patients (43.8%). The most common transition was bosentan to macitentan in eight patients (50%). Fifteen patients (93.8%) tolerated the transition after a median follow‐up of 6.5 months with minor adverse events occurring in four patients (25%). In 11 patients, 6‐min walk distance (6MWD) was unchanged comparing baseline to post transition measurements with a median change of +8 m (range: −50 to + 70; P = 0.39). Nine patients (81.8%) had stable (within 15% margin) or significant improvement (increase by ≥15%) in 6MWD after transition. All patients demonstrated stable or improved WHO FC after transition. There were no significant changes after transition in hemodynamics, N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) values, or Registry to Evaluate Early and Long‐Term PAH Disease Management (REVEAL) risk scores. In our study, transitioning patients from bosentan and sildenafil to alternative therapy was safe and resulted in clinical stability.
Association between Charlson comorbidity index and complications of endoscopic resection of gastric neoplasms in elderly patients
Authors: Kim Sunmin , Kim Dong Hyun , Park Seon-Young , Park Chang Hwan , Kim Hyun Soo , Choi Sung Kyu , Rew Jong Sun 
Published: July 2020

Abstract
Background
Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, the relationship between comorbidities and complications of endoscopic resection is not well established. Therefore, we aimed to evaluate the efficacy and safety of endoscopic resection of gastric epithelial neoplasms in extremely elderly patients.

Methods
From October 2008 to December 2017, 4475 consecutive patients underwent endoscopic resection of gastric epithelial neoplasms. Among them, 242 were 75 years or older. We assessed Charlson comorbidity index (CCI) scores, procedural outcomes, and procedure- and sedation-related complications related to endoscopic resection.

Results
Mean patient age was 78.7 ± 3.2 years. Of the 242 patients, 124 (51.2%) had low-grade dysplasia and 112 (46.3%) had adenocarcinoma. The most common comorbidity was hypertension (55.4%), followed by diabetes (23.1%). The mean CCI score was 1.67 ± 1.43. Sixty patients (24.8%) had a CCI score ≥ 3. During the procedure, 10 (4.1%) patients had desaturation that recovered by flumazenil use with mask (n = 2) or Ambu bag (n = 3) ventilation. During subsequent admission, atelectasis or pneumonia occurred in 45 (18.6%) patients, post-procedural bleeding in 12 (5.0%), and perforation in 3 (1.2%). Respiratory complications were more common in patients with a CCI score ≥ 3 (20/60, 33.3%) than in those with a CCI score < 3 (25/182, 13.7%, P = 0.002).

Conclusions
CCI score is related to respiratory complications of endoscopic resection in extremely elderly patients. Endoscopic resection must be performed cautiously, particularly in elderly patients with a high CCI score, to prevent respiratory complications.
Using predictive process monitoring to assist thrombolytic therapy decision-making for ischemic stroke patients
Authors: Xu Haifeng , Pang Jianfei , Yang Xi , Li Mei , Zhao Dongsheng 
Published: July 2020

Abstract
Background
Although clinical guidelines provide the best practice for medical activities, there are some limitations in using clinical guidelines to assistant decision-making in practical application, such as long update cycle and low compliance of doctors with the guidelines. Driven by data of actual cases, process mining technology provides the possibility to remedy these shortcomings of clinical guidelines.

Methods
We propose a clinical decision support method using predictive process monitoring, which could be complementary with clinical guidelines, to assist medical staff with thrombolytic therapy decision-making for stroke patients. Firstly, we construct a labeled data set of 1191 cases to show whether each case actually need thrombolytic therapy, and whether it conform to the clinical guidelines. After prefix extraction and filtering the control flow of completed cases, the sequences with data flow are encoded, and corresponding prediction models are trained.

Results
Compared with the labeled results, the average accuracy of our prediction models for intravenous thrombolysis and arterial thrombolysis on the test set are 0.96 and 0.91, and AUC are 0.93 and 0.85 respectively. Compared with the recommendation of clinical guidelines, the accuracy, recall and AUC of our predictive models are higher.

Conclusions
The performance and feasibility of this method are verified by taking thrombolytic decision-making of patients with ischemic stroke as an example. When the clinical guidelines are not applicable, doctors could be provided with assistant decision-making by referring to similar historical cases using predictive process monitoring.
Изучение процесса онлайн-радикализации молодежи в социальных медиа (междисциплинарный подход)
Authors: Карпова Анна Юрьевна , Савельев Алексей Олегович , Вильнин Александр Даниилович , Чайковский Денис Витольдович 
Published: July 2020

В статье доказывается, что междисциплинарный подход на основе интеграции уже показавших свою эффективность исследовательских инструментов перспективен для изучения процесса онлайн-радикализации молодежи в социальных сетях. Мы опираемся на международный опыт междисциплинарных исследований в области изучения радикализации, накопленный в таких научных центрах, как START, ICSR, CSEC, ISGA, и др.
В статье представлен опыт междисциплинарной проектной группы Томского политехнического университета по созданию прототипа программной системы для выявления ультраправых сообществ в социальной сети «ВКонтакте». Новый гибридный метод календарно-корреляционного анализа сочетает в себе скорость компьютерного анализа больших данных (чувствительный для обнаружения ультраправых сообществ), математическую модель для выявления целевой группы по характерному изменению активности группы в «окрестности» ключевых событий и базу знаний. Методика работы алгоритма позволит выявлять предикторы радикализации для разработки критериев отбора и маркирования триггерных объектов, значимых для ультрарадикальных сообществ в российской социальной сети; создать социальный граф из кластеров и перекрестных связей; прогнозировать угрозы и риски распространения радикальных идеологий. В перспективе прототип может применяться для анализа других социальных сетей и ультрарадикальных сообществ при условии пополнения базы знаний, адаптации правил анализа информации и соответствующих социологических шаблонов и моделей. Мы также излагаем исследовательские стратегии для проверки нашей методики.
Благодарность. Исследование выполнено при финансовой поддержке ГЗ «Наука», в рамках проекта FSWW-2020-0014.
Analisis Usaha Perikanan Purse Seine di Perairan Kendari, Provinsi Sulawesi Tenggara
Authors: Suharyanto Suharyanto , Saputra Rahmat Surya Hadi , Mufid Muhammad Amin , Sutono Dian 
Published: July 2020

Usaha perikanan purse seine diperairan Kendari Sulawesi Tenggara banyak diminati oleh nelayan dengan besar kapal ≤ 30 GT. Penelitian ini bertujuan untuk menganalisa kelayakan usaha perikanan purse seine di perairan Kendari. Secara keekonomian kegiatan perikanan tangkap KM. Tunas Harapan 99-02 dengan alat tangkap purse seine layak diusahakan, dengan beberapa parameter ekonomi masing-masing keuntungan sebesar Rp211.554.950,--; Net Present Value sebesar Rp816.808.430,--; Internal Rate of Return sebesar 23,35%; Net B/C Ratio 1,80 dan Payback Period 4 tahun 9 bulan 22 hari. Sehingga untuk meningkatkan kinerja usaha agar lebih besar disarankan dengan menambah jumlah hari setiap trip penangkapannya yang dapat menghemat waktu dan biaya operasional.
Comparison of Treatment Effects with Modified C-Palatal Plates vs Greenfield Molar Distalizer Appliances in Adolescents
Authors: Alfaifi Mohammed , Park Jae Hyun , Tai Kiyoshi , Ku Ja Hyeong , Vaid Nikhilesh R , Kook Yoon-Ah , Shoaib Ahmed M , Bayome Mohamed 
Published: July 2020

Objectives: The aim of study was to evaluate skeletodental and soft tissue treatment effects and the amount of maxillary molar distalization with modified C-palatal plates vs. Greenfield molar distalizer appliances in adolescents. Study design: The samples consisted of pre- and posttreatment lateral cephalograms collected from 39 patients with Class II malocclusion. The MCPP group was comprised of 21 patients (mean age: 11.7 ± 1.3 years) treated with MCPP appliances while the GMD group included 18 patients (mean age: 11.2 ± 0.9 years) treated with GMD. Fixed orthodontic treatment started with the distalization process in both groups. From each cephalograpm, twenty-nine variables were measured for analysis and then the two groups were compared. Descriptive statistics, a paired t-test, and multivariate analysis of variance were performed to compare the treatment effects within and between the groups. Results: There was significant treatmentrelated change in the sagittal position of the maxilla and the mandible within each group. However, there were no statistically significant inter-group differences. The mean maxillary first molar distalization was 3.96 mm in the MCPP group vs. 2.85 mm in the GMD group. Both groups showed minimal distal tipping, but the maxillary incisors were significantly extruded by 3.04 ± 0.89 mm (P &lt; .001) in GMD group. There was no significant difference in treatment duration between the groups.
Conclusions: The maxillary first molars of both the MCPP and GMD groups were effectively distalized and there were significant skeletal changes in the maxilla. However, the maxillary incisors were significantly extruded in the GMD group.
Les Effets IndÃ©sirables : DÃ©finition, Classification, Diagnostique Et Facteurs
Authors: El Bouazzi Omaima 
Published: July 2020

Un mÃ©dicament est capable de produire un effet thÃ©rapeutique et faire preuve dâ€™une grande efficacitÃ© comme il peut Ãªtre Ã lâ€™origine dâ€™apparition de plusieurs effets indÃ©sirables allant des plus bÃ©nins au plus grave mettant en jeu le pronostic vital du patient. De ce fait, un effet indÃ©sirable mÃ©dicamenteux peut Ãªtre dÃ©finit comme Ã©tant une rÃ©action vis-Ã -vis Ã un mÃ©dicament dans les conditions normales dâ€™utilisation ou en dehors de ces derniÃ¨res. Une bonne connaissance de lâ€™effet indÃ©sirable, sa classification, son diagnostic et des facteurs favorisants permettent une bonne gestion de lâ€™Ã©vÃ©nement et une bonne prise en charge. Lâ€™objectif de cet article est de prÃ©senter de maniÃ¨re didactique les notions fondamentales liÃ©es aux effets indÃ©sirables mÃ©dicamenteux. Il sâ€™agit dâ€™une synthÃ¨se bibliographique de 48 rÃ©fÃ©rences des articles, chapitres dâ€™ouvrage et thÃ¨ses de doctorat.
A drug is capable to produce a therapeutic effect with a great effectiveness as it can be the cause of several adverse reactions ranging from European Scientific Journal June 2020 edition Vol.16, No.18 ISSN: 1857-7881 (Print) e - ISSN 1857-7431 256 the mildest to the most serious involving the patient's life-threatening. Therefore, an adverse reaction can be defined as a reaction to a drug under normal conditions of use or outside of them. A good knowledge of the adverse reaction, its classification, its diagnosis and favorable factors allow good management of the event. The purpose of this article is to present in a didactic manner the fundamental concepts of adverse drug reactions. This is a bibliographic summary of 48 references to articles, book chapters and doctoral theses.
Drought and households’ adaptive capacity to water scarcity in Kasali, Uganda
Authors: Mukasa Joseph , Olaka Lydia , Yahya Said Mohammed 
Published: July 2020

Abstract
The world is experiencing variability in precipitation, increased temperature, drought frequencies and intensities. Globally, approximately four billion individuals experience water scarcity due to drought. In Uganda about 10% of the population in the southern and northern parts of the country experience drought related water scarcity annually. This study aimed at assessing drought and households’ adaptive capacity (AC) to water scarcity during drought in Kasali. This was done through determining drought trends from 1987 to 2017, assessing the impact of drought on water availability and the AC of households to manage water scarcity. Droughts were assessed based on the Reconnaissance Drought Index (RDI). The results show a decrease in the average annual rainfall, and the seasons of March-April-May (MAM), January-February (JF) while the seasons of September-October-November-December (SOND) and June-July-August (JJA) show an increase in rainfall trend. The average maximum and minimum annual and seasonal temperature increased significantly by between 0.56 and 1.51 °C. The minimum temperature increased more than the maximum temperature. Kasali experienced one extreme dry year and four moderate ones between 1987 and 2017. Above 70% of the households spend longer hours collecting water during dry years than wet years. The AC of households to water scarcity was low and drought negatively impacted water availability.
Climate change and its influence on design rainfall at-site in New South Wales State, Australia
Authors: Hajani Evan 
Published: July 2020

AbstractQuantification of rainfall is needed for planning, designing and operation of water engineering projects. Although there is lot of research on design rainfall in the literature, there is a lack of research considering the impact of climate change on design rainfall. This study focuses on the assessment of the impact of climate changes on design rainfall using data from New South Wales (NSW), Australia. Future stationary and non-stationary intensity–frequency–duration (IFD) curves have been estimated using generalized extreme value (GEV) distribution. The maximum-likelihood estimation method is employed to estimate the parameters of the GEV models. It has been found that the consideration of the climatic change on the rainfall data of the selected station confirms that the simulation exhibits non-stationary behaviour on the IFD curve data. In addition, the results show that when the future period increases, the relative differences between the stationary and non-stationary IFD curves generally increase. Comparison of the new IFD curves estimated in this study with the Australian Rainfall and Runoff (ARR) IFD curves demonstrates that there is a better match between the ARR IFD curves and the new stationary IFD curves compared with the non-stationary IFD curves.
Pembelajaran Bahasa Indonesia untuk Generasi Milenial
Authors: Anwar M. Shoim , Pramujiono Agung , Astuti Sri Budi , Ardianti Mimas 
Published: July 2020

Generasi milenial adalah mereka yang lahir antara awal tahun 1980 hingga awal 2000-an. Sejalan dengan revolusi industri 4.0, ciri utama mereka adalah sulit melepaskan aktivitasnya dengan perangkat komputer beserta program dan aplikasi di dalamnya. Kondisi ini menjadikan pembelajaran bahasa Indonesia, termasuk sastra di dalamnya, harus menyesuaikan diri dengan perkembangan teknologi digital dengan jaringan internet, khususnya terkait media dan bahan pembelajaran. Karakter dan nilai-nilai positif pada generasi milenial harus tetap dijaga, khususnya pada penggunaan bahasa di media sosial. Guru bahasa Indonesia harus menjadikan mereka sebagai mitra belajar dengan mengedepankan tumbuhnya sikap kritis, kreatif, inovatif, komunikatif, kolaboratif, serta menghargai perbedaan sebagai konsekuensi lintas budaya.
MANAJEMEN ULKUS KAKI DIABETIKUM : EFEKTIFITAS FOOT EXERCISE TERHADAP RISIKO DFU (DIABETIC FOOT ULCERS) PASIEN DIABETES MELLITUS DI AL HIJRAH WOUND CARE CENTER
Authors: Kurdi Fahruddin , Priyanti Ratna Puji 
Published: July 2020

ABSTRAK
Jumlah penderita DM (diabetes melitus) saat ini semakin meningkat. Salah satu komplikasi yang terjadi yaitu DFU (diabetic foot ulcers). Banyak cara yang dapat dilakukan untuk mencegah DFU, salah satunya dengan diabetic foot exercise. Penelitian ini bertujuan untuk mengetahui efektifitas diabetic foot exercise terhadap risiko dfu (diabetic foot ulcers) pasien diabetes mellitus. Penelitian menggunakan design pre-eksperimen dengan pendekatan one-group pra-post test design. Populasi penderita diabetes yang berjumlah 60 orang, besar sampel 40 orang yang diambil menggunakan teknik purposive sampling. Resiko DFU dinilai menggunakan inlow’s 60-second diabetic foot screening tool dengan metode observasi. Analisa data menggunakan uji statistik Wilcoxon. Hasil penelitian ini didapatkan bahwa sebelum dilakukan diabetic foot exercise sebagian besar reponden mempunyai risiko sedang sebanyak 30 orang (75%), sesudah dilakukan diabetic foot exercise diperoleh bahwa sebagian besar responden risiko rendah sebanyak 32 orang (80%). Uji statistik Wilcoxon diperoleh nilai p value = 0,001 dimana nilai p value<? (0,05) yang berarti ada pengaruh diabetic foot exercise terhadap risiko diabetic foot ulcers. Diabetes foot exercise sangat efektif untuk penderita diabetes dalam mencegah risiko DFU. Penderita diabetes dapat melakukan diabetic foot exercise 2 kali dalam seminggu secara teratur.
Kata Kunci : Diabetes mellitus, Diabetic foot ulcers, diabetic foot exercise