bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ionospheric Response to Strong Geomagnetic Storms During 2000–2005: An IMF Clock Angle Perspective
Authors: Chakraborty Sumanjit , Ray Sarbani , Datta Abhirup , Paul Ashik 
Published: August 2020

AbstractThis paper presents the equatorial ionospheric response to 11 strong‐to‐severe geomagnetic storms that occurred during the period 2000–2005, the declining phase of the Solar Cycle 23. The analysis has been performed using the global ion density plots of the Defense Meteorological Satellite Program (DMSP). Observations show that for about 91% of the cases, postsunset equatorial irregularities occurred within 3 hr from the time of northward to southward transition of the interplanetary magnetic field (IMF) clock angle, thus bringing out the importance of the role played by IMF By in the process of prompt penetration of electric field (PPEF) in addition to the IMF Bz. This is an improvement from the previously reported (Ray et al., 2015, https://doi.org/10.1002/2014RS005422) 4 hr window of equatorial spread F generation from the southward IMF Bz crossing −10 nT.
Process‐Level Evaluation of a Hyper‐Resolution Forest Snow Model Using Distributed Multisensor Observations
Authors: Mazzotti Giulia , Essery Richard , Webster Clare , Malle Johanna , Jonas Tobias 
Published: August 2020

AbstractThe complex dynamics of snow accumulation and melt processes under forest canopies entail major observational and modeling challenges, as they vary strongly in space and time. In this study, we present novel data sets acquired with mobile multisensor platforms in subalpine and boreal forest stands. These data sets include spatially and temporally resolved measurements of shortwave and longwave irradiance, air and snow surface temperatures, wind speed, and snow depth, all coregistered to canopy structure information. We then apply the energy balance snow model FSM2 to obtain concurrent, distributed simulations of the forest snowpack at very high (“hyper”) resolution (2 m). Our data sets allow us to assess the performance of alternative canopy representation strategies within FSM2 at the level of individual snow energy balance components and in a spatially explicit manner. We demonstrate the benefit of accounting for detailed spatial patterns of shortwave and longwave radiation transfer through the canopy and show the importance of describing wind attenuation by the canopy using stand‐scale metrics. With the proposed canopy representation, snowmelt dynamics in discontinuous forest stands were successfully reproduced. Hyper‐resolution simulations resolving these effects provide an optimal basis for assessing the snow‐hydrological impacts of forest disturbances and for validating and improving the representation of forest snow processes in land surface models intended for coarser‐scale applications.
Phase 2 study of irinotecan plus cetuximab rechallenge as third-line treatment in KRAS wild-type metastatic colorectal cancer: JACCRO CC-08
Authors: Masuishi Toshiki , Tsuji Akihito , Kotaka Masahito , Nakamura Masato , Kochi Mitsugu , Takagane Akinori , Shimada Ken , Denda Tadamichi , Segawa Yoshihiko , Tanioka Hiroaki , Hara Hiroki , Sagawa Tamotsu , Watanabe Takanori , Takahashi Takao , Negoro Yuji , Manaka Dai , Fujita Hideto , Suto Takeshi , Takeuchi Masahiro , Ichikawa Wataru , Fujii Masashi 
Published: August 2020

Abstract
Background
Regorafenib or trifluridine/tipiracil as third-line treatment have limited efficacy in metastatic colorectal cancer (mCRC).

Methods
This Phase 2 trial evaluated the efficacy and safety of irinotecan plus cetuximab rechallenge as third-line treatment in KRAS wild-type mCRC patients who achieved clinical benefit with first-line cetuximab-containing therapy. The primary endpoint was 3-month progression-free survival (PFS) rate. A sample size was calculated; 30 patients with a 3-month PFS rate of 45% deemed promising and 15% unacceptable. Patients with greater and less than the cut-off value of cetuximab-free intervals (CFIs) were classified into the long and short CFI groups, respectively, in subgroup analyses.

Results
Among 34 eligible patients who received treatment at least once, 3-month PFS rate was 44.1% (95% confidence interval, 27.4–60.8%). The median PFS and overall survival (OS) were 2.4 and 8.2 months, respectively. The response and disease control rates were 2.9 and 55.9%, respectively. PFS and OS were significantly longer in the long- than in the short CFI group.

Conclusions
Irinotecan plus cetuximab rechallenge as third-line treatment for KRAS wild-type mCRC was safe and had promising activity, especially in those with a long CFI, warranting further investigation in a Phase 3 randomised trial.

Clinical trial registration
UMIN000010638
Dynamics for El Niño-La Niña asymmetry constrain equatorial-Pacific warming pattern
Authors: Hayashi Michiya , Jin Fei-Fei , Stuecker Malte F. 
Published: August 2020

AbstractThe El Niño-Southern Oscillation (ENSO) results from the instability of and also modulates the strength of the tropical-Pacific cold tongue. While climate models reproduce observed ENSO amplitude relatively well, the majority still simulates its asymmetry between warm (El Niño) and cold (La Niña) phases very poorly. The causes of this major deficiency and consequences thereof are so far not well understood. Analysing both reanalyses and climate models, we here show that simulated ENSO asymmetry is largely proportional to subsurface nonlinear dynamical heating (NDH) along the equatorial Pacific thermocline. Most climate models suffer from too-weak NDH and too-weak linear dynamical ocean-atmosphere coupling. Nevertheless, a sizeable subset (about 1/3) having relatively realistic NDH shows that El Niño-likeness of the equatorial-Pacific warming pattern is linearly related to ENSO amplitude change in response to greenhouse warming. Therefore, better simulating the dynamics of ENSO asymmetry potentially reduces uncertainty in future projections.
Effective plans for hospital system response to earthquake emergencies
Authors: Ceferino Luis , Mitrani-Reiser Judith , Kiremidjian Anne , Deierlein Gregory , Bambarén Celso 
Published: August 2020

AbstractHospital systems play a critical role in treating injuries during disaster emergency responses. Simultaneously, natural disasters hinder their ability to operate at full capacity. Thus, cities must develop strategies that enable hospitals’ effective disaster operations. Here, we present a methodology to evaluate emergency response based on a model that assesses the loss of hospital functions and quantifies multiseverity injuries as a result of earthquake damage. The proposed methodology can design effective plans for patient transfers and allocation of ambulances and mobile operating rooms. This methodology is applied to Lima, Peru, subjected to a disaster scenario following a magnitude 8.0 earthquake. Our results show that the spatial distribution of healthcare demands mismatches the post-earthquake capacities of hospitals, leaving large zones on the periphery significantly underserved. This study demonstrates how plans that leverage hospital-system coordination can address this demand-capacity mismatch, reducing waiting times of critically injured patients by factors larger than two.
Highly efficient eco-friendly X-ray scintillators based on an organic manganese halide
Authors: Xu Liang-Jin , Lin Xinsong , He Qingquan , Worku Michael , Ma Biwu 
Published: August 2020

AbstractScintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C38H34P2)MnBr4), which can be prepared using a facile solution growth method at room temperature to form inch sized single crystals. This zero-dimensional organic metal halide hybrid exhibits green emission peaked at 517 nm with a photoluminescence quantum efficiency of ~ 95%. Its X-ray scintillation properties are characterized with an excellent linear response to X-ray dose rate, a high light yield of ~ 80,000 photon MeV−1, and a low detection limit of 72.8 nGy s−1. X-ray imaging tests show that scintillators based on (C38H34P2)MnBr4 powders provide an excellent visualization tool for X-ray radiography, and high resolution flexible scintillators can be fabricated by blending (C38H34P2)MnBr4 powders with polydimethylsiloxane.
Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
Authors: Ianiro Gianluca , Rossi Ernesto , Thomas Andrew M. , Schinzari Giovanni , Masucci Luca , Quaranta Gianluca , Settanni Carlo Romano , Lopetuso Loris Riccardo , Armanini Federica , Blanco-Miguez Aitor , Asnicar Francesco , Consolandi Clarissa , Iacovelli Roberto , Sanguinetti Maurizio , Tortora Giampaolo , Gasbarrini Antonio , Segata Nicola , Cammarota Giovanni 
Published: August 2020

AbstractDiarrhoea is one of the most burdensome and common adverse events of chemotherapeutics, and has no standardised therapy to date. Increasing evidence suggests that the gut microbiome can influence the development of chemotherapy-induced diarrhoea. Here we report findings from a randomised clinical trial of faecal microbiota transplantation (FMT) to treat diarrhoea induced by tyrosine kinase inhibitors (TKI) in patients with metastatic renal cell carcinoma (ClinicalTrials.gov number: NCT04040712). The primary outcome is the resolution of diarrhoea four weeks after the end of treatments. Twenty patients are randomised to receive FMT from healthy donors or placebo FMT (vehicle only). Donor FMT is more effective than placebo FMT in treating TKI-induced diarrhoea, and a successful engraftment is observed in subjects receiving donor faeces. No serious adverse events are observed in both treatment arms. The trial meets pre-specified endpoints. Our findings suggest that the therapeutic manipulation of gut microbiota may become a promising treatment option to manage TKI-dependent diarrhoea.
A Mn-N3 single-atom catalyst embedded in graphitic carbon nitride for efficient CO2 electroreduction
Authors: Feng Jiaqi , Gao Hongshuai , Zheng Lirong , Chen Zhipeng , Zeng Shaojuan , Jiang Chongyang , Dong Haifeng , Liu Licheng , Zhang Suojiang , Zhang Xiangping 
Published: August 2020

AbstractDeveloping effective catalysts based on earth abundant elements is critical for CO2 electroreduction. However, simultaneously achieving a high Faradaic efficiency (FE) and high current density of CO (jCO) remains a challenge. Herein, we prepare a Mn single-atom catalyst (SAC) with a Mn-N3 site embedded in graphitic carbon nitride. The prepared catalyst exhibits a 98.8% CO FE with a jCO of 14.0 mA cm−2 at a low overpotential of 0.44 V in aqueous electrolyte, outperforming all reported Mn SACs. Moreover, a higher jCO of 29.7 mA cm−2 is obtained in an ionic liquid electrolyte at 0.62 V overpotential. In situ X-ray absorption spectra and density functional theory calculations demonstrate that the remarkable performance of the catalyst is attributed to the Mn-N3 site, which facilitates the formation of the key intermediate COOH* through a lowered free energy barrier.
Electric field control of radiative heat transfer in a superconducting circuit
Authors: Maillet Olivier , Subero Diego , Peltonen Joonas T. , Golubev Dmitry S. , Pekola Jukka P. 
Published: August 2020

AbstractHeat is detrimental for the operation of quantum systems, yet it fundamentally behaves according to quantum mechanics, being phase coherent and universally quantum-limited regardless of its carriers. Due to their robustness, superconducting circuits integrating dissipative elements are ideal candidates to emulate many-body phenomena in quantum heat transport, hitherto scarcely explored experimentally. However, their ability to tackle the underlying full physical richness is severely hindered by the exclusive use of a magnetic flux as a control parameter and requires complementary approaches. Here, we introduce a dual, magnetic field-free circuit where charge quantization in a superconducting island enables thorough electric field control. We thus tune the thermal conductance, close to its quantum limit, of a single photonic channel between two mesoscopic reservoirs. We observe heat flow oscillations originating from the competition between Cooper-pair tunnelling and Coulomb repulsion in the island, well captured by a simple model. Our results highlight the consequences of charge-phase conjugation on heat transport, with promising applications in thermal management of quantum devices and design of microbolometers.
Ion mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomics
Authors: Zhou Zhiwei , Luo Mingdu , Chen Xi , Yin Yandong , Xiong Xin , Wang Ruohong , Zhu Zheng-Jiang 
Published: August 2020

AbstractThe metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a promising technology by providing multi-dimensional characterizations of metabolites. Here, we curate an ion mobility CCS atlas, namely AllCCS, and develop an integrated strategy for metabolite annotation using known or unknown chemical structures. The AllCCS atlas covers vast chemical structures with >5000 experimental CCS records and ~12 million calculated CCS values for >1.6 million small molecules. We demonstrate the high accuracy and wide applicability of AllCCS with medium relative errors of 0.5–2% for a broad spectrum of small molecules. AllCCS combined with in silico MS/MS spectra facilitates multi-dimensional match and substantially improves the accuracy and coverage of both known and unknown metabolite annotation from biological samples. Together, AllCCS is a versatile resource that enables confident metabolite annotation, revealing comprehensive chemical and metabolic insights towards biological processes.
Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
Authors: Parua Pabitra K. , Kalan Sampada , Benjamin Bradley , Sansó Miriam , Fisher Robert P. 
Published: August 2020

AbstractReversible phosphorylation of Pol II and accessory factors helps order the transcription cycle. Here, we define two kinase-phosphatase switches that operate at different points in human transcription. Cdk9/cyclin T1 (P-TEFb) catalyzes inhibitory phosphorylation of PP1 and PP4 complexes that localize to 3′ and 5′ ends of genes, respectively, and have overlapping but distinct specificities for Cdk9-dependent phosphorylations of Spt5, a factor instrumental in promoter-proximal pausing and elongation-rate control. PP1 dephosphorylates an Spt5 carboxy-terminal repeat (CTR), but not Spt5-Ser666, a site between Kyrpides-Ouzounis-Woese (KOW) motifs 4 and 5, whereas PP4 can target both sites. In vivo, Spt5-CTR phosphorylation decreases as transcription complexes pass the cleavage and polyadenylation signal (CPS) and increases upon PP1 depletion, consistent with a PP1 function in termination first uncovered in yeast. Depletion of PP4-complex subunits increases phosphorylation of both Ser666 and the CTR, and promotes redistribution of promoter-proximally paused Pol II into gene bodies. These results suggest that switches comprising Cdk9 and either PP4 or PP1 govern pause release and the elongation-termination transition, respectively.
Anharmonic quantum nuclear densities from full dimensional vibrational eigenfunctions with application to protonated glycine
Authors: Aieta Chiara , Micciarelli Marco , Bertaina Gianluca , Ceotto Michele 
Published: August 2020

AbstractThe interpretation of molecular vibrational spectroscopic signals in terms of atomic motion is essential to understand molecular mechanisms and for chemical characterization. The signals are usually assigned after harmonic normal mode analysis, even if molecular vibrations are known to be anharmonic. Here we obtain the quantum anharmonic vibrational eigenfunctions of the 11-atom protonated glycine molecule and we calculate the density distribution of its nuclei and its geometry parameters, for both the ground and the O-H stretch excited states, using our semiclassical method based on ab initio molecular dynamics trajectories. Our quantum mechanical results describe a molecule elongated and more flexible with respect to what previously thought. More importantly, our method is able to assign each spectral peak in vibrational spectroscopy by showing quantitatively how normal modes involving different functional groups cooperate to originate that spectroscopic signal. The method will possibly allow for a better rationalization of experimental spectroscopy.
Direct observation of desorption of a melt of long polymer chains
Authors: Monnier Xavier , Napolitano Simone , Cangialosi Daniele 
Published: August 2020

AbstractTuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would result in desorption, thereby reverting the thermodynamic state of the interface, has so far remained elusive, due to the interference of degradation. Here, we employ fast scanning calorimetry, allowing to investigate the thermodynamics of the interface while heating at 104 K s−1. We show that applying such rate to adsorbed polymer layers permits avoiding degradation and, therefore, we provide clear-cut evidence of desorption of a polymer melt. We found that the enthalpy and temperature of desorption are independent of the annealing temperature, which, in analogy to crystallization/melting, indicates that adsorption/desorption is a first order thermodynamic transition.
Surveillance of cohesin-supported chromosome structure controls meiotic progression
Authors: Castellano-Pozo Maikel , Pacheco Sarai , Sioutas Georgios , Jaso-Tamame Angel Luis , Dore Marian H. , Karimi Mohammad M. , Martinez-Perez Enrique 
Published: August 2020

AbstractChromosome movements and programmed DNA double-strand breaks (DSBs) promote homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves checkpoint-controlled termination of these events when all homologue pairs achieve synapsis and form crossover precursors. Exploiting the temporo-spatial organisation of the C. elegans germline and time-resolved methods of protein removal, we show that surveillance of the synaptonemal complex (SC) controls meiotic progression. In nuclei with fully synapsed homologues and crossover precursors, removing different meiosis-specific cohesin complexes, which are individually required for SC stability, or a SC central region component causes functional redeployment of the chromosome movement and DSB machinery, triggering whole-nucleus reorganisation. This apparent reversal of the meiotic programme requires CHK-2 kinase reactivation via signalling from chromosome axes containing HORMA proteins, but occurs in the absence of transcriptional changes. Our results uncover an unexpected plasticity of the meiotic programme and show how chromosome signalling orchestrates nuclear organisation and meiotic progression.
Insights into projected changes in marine heatwaves from a high-resolution ocean circulation model
Authors: Hayashida Hakase , Matear Richard J. , Strutton Peter G. , Zhang Xuebin 
Published: August 2020

AbstractGlobal climate models project the intensification of marine heatwaves in coming decades due to global warming. However, the spatial resolution of these models is inadequate to resolve mesoscale processes that dominate variability in boundary current regions where societal and economic impacts of marine heatwaves are substantial. Here we compare the historical and projected changes in marine heatwaves in a 0.1° ocean model with 23 coarser-resolution climate models. Western boundary currents are the regions where the models disagree the most with observations and among themselves in simulating marine heatwaves of the past and the future. The lack of eddy-driven variability in the coarse-resolution models results in less intense marine heatwaves over the historical period and greater intensification in the coming decades. Although the projected changes agree well at the global scale, the greater spatial details around western boundary currents provided by the high-resolution model may be valuable for effective adaptation planning.
Stunting of children under two from repeated pregnancy among young mothers
Authors: Maravilla Joemer Calderon , Betts Kim , Adair Linda , Alati Rosa 
Published: August 2020

AbstractRepeated pregnancy leaves young mothers nutritionally deprived which may in turn lead to poor infant growth. We measure the occurrence and persistence of stunting among offspring of young mothers who experienced repeated pregnancies using data from the Cebu Longitudinal Health and Nutrition Survey. We selected mothers aged 14–24 years (n = 1,033) with singleton birth. We determined the length-for-age z scores (LAZ) at 12 and 24 months of the index child using the World Health Organisation 2007 growth standard. We fitted LAZ, stunting occurrence (i.e. LAZ < − 2) and persistence from 12 to 24 months into regression models and tested for the mediating effect of low birthweight and feeding practices. In these models, repeated pregnancy was analysed in an ordinal approach using number of past pregnancies of young mothers at birth of the index child. Compared to infants born to young mothers aged 14–24 years who had no previous pregnancies, those born to young mothers with repeated pregnancies have at least 0.15 (95% CI − 0.23, − 0.08) LAZ lower and are at higher chance of stunting by at least 40% (95% CI 1.19, 1.67) at 12 and 24 months. Similar cohorts of infants showed an elevated risk of persistent stunting from 12 through 24 months with a relative risk ratio of 1.51 (95% CI 1.21, 1.88). Optimal feeding practices substantially mediated stunting outcomes by further reducing the effects of repeated pregnancy to stunting occurrence and persistence by 19.95% and 18.09% respectively. Mediation tests also showed low birthweight in the causal pathway between repeated pregnancy and stunting. Repeated pregnancy in young mothers is a predictor of stunting among children under 2 years. Secondary pregnancy prevention measures and addressing suboptimal feeding practices are beneficial to mitigate the negative impact of repeated adolescent pregnancy on children.