bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Plasticity and Evolutionary Adaptation of Allosteric Regulation
Authors: Leander Megan , Yuan Yuchen , Meger Anthony , Cui Qiang , Raman Srivatsan 
Published: February 2020

AbstractAllostery is a fundamental regulatory mechanism of protein function. Despite notable advances, understanding the molecular determinants of allostery remains an elusive goal. Our current knowledge of allostery is principally shaped by a structure-centric view which makes it difficult to understand the decentralized character of allostery. We present a function-centric approach using deep mutational scanning to elucidate the molecular basis and underlying functional landscape of allostery. We show that allosteric signaling exhibits a high-degree of functional plasticity and redundancy through myriad mutational pathways. Residues critical for allosteric signaling are surprisingly poorly conserved while those required for structural integrity are highly conserved, suggesting evolutionary pressure to preserve fold over function. Our results suggest multiple solutions to the thermodynamic conditions of cooperativity, in contrast to the common view of a finely-tuned allosteric residue network maintained under selection.
Membrane-Bound O-Acyltransferase 7 (MBOAT7) is a Key Regulator of Glycolysis in Clear Cell Renal Carcinoma
Authors: Neumann Chase K. A. , Massey William , Orabi Danny , Zhang Renliang , Silver Daniel J. , Lathia Justin D. , Brown J. Mark 
Published: February 2020

AbstractObjectiveThe most common and deadliest urological cancer is clear cell Renal Cell Carcinoma (ccRCC). ccRCC is characterized by striking reorganization of both carbohydrate and lipid metabolism. It was recently demonstrated that lipid remodeling enzyme Membrane-Bound O-Acyltransferase 7 (MBOAT7) that generates phosphatidylinositol (PI) is important for the ccRCC progression. However, whether MBOAT7-driven PI remodeling is associated with other metabolic alterations commonly found in ccRCC is poorly understood.MethodsMBOAT7 deficient ccRCC cell lines were generated by genome editing, and were characterized by a general reduction in glycolytic capactiy. Using targeted metabolomics approach in Caki-1 cells, we measured the glycolytic intermediates and the relative expression of key glycolytic enzymes. We also measured basal respiration and maximal respiration with MBOAT7 deficiency in the presence of glucose. Lastly, in vivo xenograft studies were performed with parental and MBOAT7 deficient cells.ResultsMBOAT7 deficiency was associated with a reduction in glycolytic gene expression and protein abundance. In parallel, we found that glycolytic intermediates similarly decreased which may contribute to a reduction in glycolysis. MBOAT7 deficiency reduces basal respiration and maximal respiration. Similarly, we see maximum glycolytic capacity also reduced with MBOAT7 loss of function. Finally, the in vivo xenograft demonstrated MBOAT7 knockout significantly increased overall survival and reduced glycolyticHK2protein abundancein vivo.ConclusionsOur work highlights MBOAT7 as a key regulator of glycolysis in ccRCC. Our data provides additional evidence that suggests MBOAT7 as a novel target to regulate tumor growthin vivo.
Metadata evaluation criteria in respect to archival maps description
Authors: Kuźma Marta , Mościcka Albina 
Published: February 2020

Purposes
This paper aims to present an objective summary of the current state of research concerning the evaluation criteria of map metadata. The undertaken research identifies which authors and to what extent the discussed issues related to the metadata of objects collected in digital libraries, with particular emphasis on cartographic materials.

Design/methodology/approach
Independent reviewers analysed the basic articles data. Selected papers were subject to quality assessment, based on the full text and 12 questions. Finally, iterative backward reference search was conducted.

Findings
The results demonstrate that there are no universal criteria for metadata evaluation. There are no works that would assess the metadata of cartographic studies, although numerous publications point to the need for this type of work.

Practical implications
Metadata evaluation allows users to obtain knowledge whether objects found in the library are relevant for their needs.

Originality/value
The criteria and methods most often used for assessing metadata quality which can be adopted to map metadata evaluation have been identified. The authors identified the existing research gaps and proved that there is a need for research contributions in the field of evaluating map metadata.
Use of scholarly communication and citation-based metrics as a basis for university ranking in developing country perspective
Authors: Hossain Md. Noman , Ahmed S.M. Zabed 
Published: February 2020

Purpose
The purpose of this paper is to use scholarly communication and citation data to rank the universities in a developing country perspective in Bangladesh.

Design/methodology/approach
This paper used publication and citation data from Scopus to rank the universities in Bangladesh. The number of papers published in each year during 2008-2018 by the select 33 universities, faculty per capita, the two-year citations and the number cited articles were used to arrive at a yearly weighted score and overall score for each university. The overall score was used to produce the ranking of the universities in Bangladesh.

Findings
The findings indicate that the ranking system can be implemented at the national level as an annual exercise to rank the higher education institutions in developing country perspective.

Originality/value
This is the first time an effort has been made to rank the universities in Bangladesh using publication and citation data. The findings of this paper could help policymakers, administrators and academicians to understand how the universities are performing in terms of scholarly activities.
An expanded nomological network of experienscape
Authors: Tasci Asli D.A. , Pizam Abraham 
Published: February 2020

PurposeBitner’s (1992) concept of servicescape has received widespread academic attention, resulting in many conceptual and empirical studies. By scanning the servicescape literature and other relevant concepts, Pizam and Tasci (2019) provided experienscape, an expanded version of servicescape, to be measured from different stakeholders’ perspectives with a multidisciplinary approach. This paper aims to build on Pizam and Tasci’s conceptualization of experienscape and expand its nomological network with other pertinent concepts related to different stakeholders with an interdisciplinary approach.Design/methodology/approachThis is a conceptual study analyzing diverse literature related to servicescape, experienscape and other related concepts and theories to provide an integrated and holistic picture of experienscape for more robust theory development. Several new relationships are synthesized for hypothesis development and testing in future research.FindingsThe review of past research reveals that servicescape literature has mostly focused on outcomes for the benefit of brands and firms and missed outcomes for consumers and other stakeholders. In addition, servicescape literature lacks several critical concepts in the affective, cognitive and behavioral reaction domains, as well as moderator factors. The relevance of some theories such as branding (e.g. brand identity, personality, image, perceived quality, consumer value, brand value and self-congruity), cocreation/coproduction/codestruction, transformation, subjective happiness, subjective well-being and quality of life is completely overlooked.Research limitations/implicationsExperienscape is a container of complex systems where needs, wants and expectations of multiple stakeholders are entertained, often at the same time through dynamic interactions among multiple stakeholders. Thus, a holistic understanding of experienscape requires dynamic integration of theories explaining the behavior of different stakeholders by cross-fertilizing theories through interdisciplinary research rather than unidisciplinary or multidisciplinary research conducted in separate silos.Originality/valueBy adopting Pizam and Tasci’s (2019) experienscape concept, this study expanded the relational network of service environment components (i.e. sensory, functional, social, natural and cultural components of experienscape) by incorporating diverse theories and concepts that explain cognitive, affective and conative reactions of different stakeholders to an experience environment. Additionally, the current study recommends attention to human-centric outcomes such as transformation, subjective well-being, subjective happiness and quality of life, which were completely overlooked in previous servicescape research.
Designing with care
Authors: Robinson Heather , Al-Freih Maha , Kilgore Whitney 
Published: February 2020

PurposeThe purpose of this study was to explore how care theory and the ethics of care are explained by students in the online environment to clarify the factors that are more relevant in establishing and maintaining caring relations in online learning context.Design/methodology/approachUtilizing naturalistic inquiry, the researchers interviewed online students and coded transcripts using multiple coding methods within two phases of analysis. Noddings' framework for ethics of care was utilized to identify strategies and practices that enhance each of Noddings' elements in an online course experience.FindingsThe findings of this exploratory study provide evidence on how learners perceive being cared for and highlight specific instructor behaviors and course design elements that support the emergence and maintenance of a climate of care in an online learning environment. Indicators of all four elements of Noddings' framework were present in the interviews. Within the themes of each element, strategies and practices to enhance each element in an online course experience are further explained.Research limitations/implicationsEstablishing a climate of care, whether in traditional or online learning, leads to more inclusive learning experiences that are responsive to the needs of all learners. This study brought to light some of the factors that are more relevant in establishing and maintaining caring relations in online learning context.Originality/valueThe findings of this study add to the literature on the role of emotions in an online learning as viewed through the lens of care theory. The findings highlight some strategies and behaviors that promote a climate of care in an online environment from a learner's perspective.
Is management education preparing future leaders for sustainable business?
Authors: Marathe Gaurav Manohar , Dutta Tanusree , Kundu Sayantan 
Published: February 2020

Purpose
The study aims to examine whether management education can successfully cultivate the competency of empathy that is needed in future corporate leaders to promote sustainability initiatives catering to diverse stakeholders.

Design/methodology/approach
The research highlights the impact of management education on cognitive and affective empathy by analysing the interpersonal reflectivity scores of entering students enrolled in a two-year, full-time MBA programme and the scores of the same students at graduation.

Findings
The findings show that management education has a positive impact on cognitive empathy, while it reduces affective empathy and general empathy. Further, findings show that the management curriculum brings cognitive and affective empathy to an equilibrium level that is needed for a competitive business environment.

Research limitations/implications
The research focussed only on the change in empathy of the participants (students) during management education and not during actual corporate work.

Practical implications
The research infers that current management education creates future executives with higher cognitive empathy. It argues that they would care more about the sustainability of the business in terms of profit or access to capital rather than care and concern for all the stakeholders, society and the environment. A new paradigm in management education also needs to be focussed around inculcating how to empathise affectively.

Originality/value
The study presents an empirical analysis suggesting that management education is opening the mind but not the heart. It raises a significant concern that higher management curriculum is not developing future executives who can lead the sustainability initiatives.
Persistence of bribery in West African countries
Authors: Saddiq Sani Abubakar , Abu Bakar Abu Sufian 
Published: February 2020

Purpose
The purpose of this paper is to empirically test persistence of bribery transactions in West African countries in spite of combative policy measures put in place by various governments in the sub-continent.

Design/methodology/approach
Data for this paper is obtained from the data set of Trace International’s Bribery Risk Matrix covering 2016 to 2018. The matrix is used to allow firms to determine risks associated with contact with government officials in a particular country. The data set is used to test this paper’s hypotheses. The generalize methods of moments (GMM) was used to estimate panel data of 16 West African Countries in STATA 14.0.

Findings
The result of the estimations reveals that in spite of combative policy measures put in place and millions of dollars spent, bribery is on the increase in West African countries.

Originality/value
Prior studies tend to focus on prevalence and pervasiveness of bribery transactions across the globe. This paper is one of the few that focuses on persistence of bribery particularly in West African countries.
Is the fraud diamond perspective valid in Kenya?
Authors: Omukaga Kizito Ojilong’ 
Published: February 2020

Purpose
The purpose of this study was to determine the influence of the elements of the fraud diamond theory in detecting financial statement fraud among non-financial firms in Kenya. Secondary data used to calculate ratios and figures representing the study variables was collected using a checklist for each of the targeted firms listed in the Nairobi Securities Exchange in Kenya for the 2013-2017 period.

Design/methodology/approach
Secondary data used to calculate ratios and figures representing the study variables was collected using a checklist for each of the targeted firms listed in the Nairobi Securities Exchange in Kenya for the 2013-2017 period. Convenience sampling technique was used to come up with a sample size of 35 out of the targeted population of 45 non-financial firms listed in Kenya (78% representation). This sample size was representative enough of the targeted population.

Findings
The results strongly supported that all the four elements of the fraud diamond triangle influenced financial statement fraud in Kenya. However, using three parameters, namely R2, predicted sign and standard error, to compare the applicability of either the Yoon et al. (2006) or the modified Jones (1991), our study findings are mixed. It is therefore imperative that a new model should be developed in detecting earnings management in the Kenyan context. Note that including other variables will to a greater extent increase the explanatory power in detecting earnings management practiced by non-financial firms listed in Kenya.

Research limitations/implications
Use of secondary information in the study was one limitation. Certain financial information was missing from some of the targeted firms’ official websites and the Nairobi Securities Exchange research handbooks. The researcher ensured that only non-financial firms whose audited financial statements were easily accessible were included in the study. Firms whose records were not readily available were excluded from the survey.

Practical implications
Practically, this study enables regulatory authorities in Kenya to understand the extent with which each element of the fraud diamond theory could be relied on in detecting financial statement fraud. Moreover, it will advise them on the areas to lay more emphasis when attempting to detect financial statement fraud using this model.

Originality/value
The main value of this study is the determination of the key elements of the fraud diamond theory, which have influence on financial statement fraud among non-financial firms listed in Kenya.
Individual choice of management research agendas
Authors: El-Bassiouny Noha , Amin Ahmed , Jamal Ahmad 
Published: February 2020

Purpose
The main research attempts guiding questions about management research agendas had been relevance questions versus rigor questions. Researchers have also attempted to set management research agendas in particular sectors. To the best of the authors’ knowledge, no research, however, has addressed the infrastructural and foundational questions of what moral priorities and ethical principles should guide the future development of management research. Because the Islamic theological approach is a “transcendental values integration” approach, it presents a potentially viable source of reference particularly for scholars interested in ethical philosophical paradigmatic approaches. Islamic literature has presented guiding principles as to how to balance priorities through the Jurisprudence of Priorities (Fiqh Al-Awlawiyyat). The purpose of this exploratory conceptual paper is to synchronize the Islamic background literature on the jurisprudence of priorities with management research development and agendas. The research is exploratory in nature.

Design/methodology/approach
The paper is conceptual, merging Islamic literature with management research for the development of a framework to potentially guide management researchers in prioritizing their research agendas.

Findings
The research resulted in the conceptualization of a framework aiding researchers in the prioritization of their research agendas.

Research limitations/implications
The research has implications for management scholars who are interested to prioritize their research projects and agendas. The research presents a schematic diagram and guiding framework through which scholars can reflect on their choice of research topics.

Practical implications
The research is also relevant to funding agencies as they devise the funding priorities in the management field.

Originality/value
This paper addresses the unique and foundational question of what moral priorities and ethical principles should guide the future development of management research. The authors build on a religious-philosophical approach, drawing on the Islamic jurisprudence of priorities as a literature base. The authors, therefore, address the key principles of responsible research regarding how it can be relevant on the infrastructural level to society and how the benefit to key stakeholders should be tackled. To the authors’ knowledge, this was not done in previous literature.
Purchasing functional foods to stay fit
Authors: Hassan Hasliza , Sade Abu Bakar , Subramaniam Lohan Selva 
Published: February 2020

Purpose
Health fitness has become a major issue in Malaysia since the population of overweight and obesity is becoming critical. One of the ways to achieve optimum health fitness is by consistently consuming balanced diet meals. Hence, this paper aims to focus on the willingness of society to purchase functional foods as an alternative for their daily meals to stay fit.

Design/methodology/approach
The research framework was developed based on a combination of findings by other research scholars within a similar field. The willingness to purchase functional foods to stay fit is positioned as the dependent variable, while lifestyle adaptation, social media influence and food consumption awareness are placed as the independent variables. Quantitative research was conducted by collecting primary data from respondents in Kuala Lumpur, Malaysia. The collected data were analysed using descriptive and regression analyses.

Findings
The willingness to purchase functional foods to stay fit is dependent on the lifestyle adaptation, social media influence and food consumption awareness.

Research limitations/implications
Although the current market for functional foods in Malaysia is still at a small scale, the market for this industry seems very promising. Nevertheless, greater awareness on functional food is still needed.

Practical implications
Functional food producers should make an effort to gain the untapped market by focussing on the lifestyle adaptation, social media influence and food consumption awareness.

Originality/value
This research is a breakthrough to discover the willingness of Malaysians to purchase functional food to stay fit, which is influenced by lifestyle adaptation, social media and food consumption awareness.
Logistics innovation capability and its impacts on the supply chain risks in the Industry 4.0 era
Authors: Wang Michael , Asian Sobhan , Wood Lincoln C. , Wang Bill 
Published: February 2020

PurposeThe purpose of the paper is to present an empirical study on the logistics innovation capability and its impacts on the supply chain risk in the Australian courier firms. Based on the resource-based review, logistics innovation capability provides valuable insight into mitigating supply chain risks in the Industry 4.0 era.Design/methodology/approachThe research model focuses on the relationships between logistics innovation capability and supply chain risk. Partial least squares approach for structural equation modelling is used to validate the research model by empirically analysing survey data.FindingsThe empirical result shows negative relationships between logistics innovation capability and supply chain risks. These relationships may imply that firms can mitigate the negative impacts of supply chain risks by developing logistics innovation capabilities. The findings demonstrate the applicability of logistics innovation capability for mitigating supply chain risks in the Australian courier firms.Originality/valueThere are very few empirical studies on the mitigating supply chain risk through logistics innovation capability. The empirical results provide an insight into innovation management and risk management in logistics and supply chain. This insight offers practical guidance for developing and deploying logistics innovation capability to support and enable supply chain risk management strategies in the Industry 4.0 era.
Effect of nAl2O3 on the part density and microstructure during the laser-based powder bed fusion of AlSi10Mg composite
Authors: Du Zhenglin , Chen Hui-Chi , Tan Ming Jen , Bi Guijun , Chua Chee Kai 
Published: February 2020

Purpose
In recent years, additive manufacturing techniques have attracted much research attention because of their ability to fabricate customised parts with complex geometry. The range of composites suitable for laser-based powder bed fusion technique is limited, and has not been investigated yet. This paper aims to study the fabrication of AlSi10Mg reinforced with nAl2O3 using the laser-based powder bed fusion technique.

Design/methodology/approach
An experimental approach was used to investigate the densification of AlSi10Mg–nAl2O3 composites using laser-based powder bed fusion technique. Optimisation of the porosity was performed, and microstructure evolution was evaluated.

Findings
In this study, laser volumetric energy density (approximately 109 J/mm3) was found to be required for the fabrication of AlSi10Mg–nAl2O3 composites with a relative volumetric density approximating 99%. The use of laser volumetric energy density resulted in larger grains. Columnar grain structure was observed via the use of electron backscatter diffraction mapping.

Originality/value
This paper examines the processing of new aluminium composite material suitable for the fabrication via the laser-based powder bed fusion technique.