bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human fecal microbiota is associated with colorectal cancer
Authors: Yao Qiulin , Tang Meifang , Zeng Liuhong , Chu Zhonghua , Sheng Hui , Zhang Yuyu , Zhou Yuan , Zhang Hongyun , Jiang Huayan , Ye Mingzhi 
Published: November 2020

AbstractBackgroundColorectal cancer (CRC) is one of the most common cancers. In recent studies, the gut microbiota has been reported to be potentially involved in aggravating or favoring CRC development. However, little is known about the microbiota composition in CRC patients after treatment. In this study, we explored the fecal microbiota composition to obtain a periscopic view of gut microbial communities. We analyzed microbial 16S rRNA genes from 107 fecal samples of Chinese individuals from three groups, including 33 healthy individuals (Normal), 38 CRC patients (Fa), and 36 CRC post-surgery patients (Fb).ResultsSpecies richness and diversity were decreased in the Fa and Fb groups compared with that of the Normal group. Partial least squares discrimination analysis showed clustering of samples according to disease with an obvious separation between the Fa and Normal, and Fb and Normal groups, as well as a partial separation between the Fa and Fb groups. Based on linear discriminant analysis effect size analysis and a receiver operating characteristic model,Fusobacteriumwas suggested as a potential biomarker for CRC screening. Additionally, we found that surgery greatly reduced the bacterial diversity of microbiota in CRC patients. Some commensal beneficial bacteria of the intestinal canal, such asFaecalibacteriumandPrevotella, were decreased, whereas the drug-resistantEnterococcuswas visibly increased in CRC post-surgery group. Meanwhile, we observed a declining tendency ofFusobacteriumin the majority of follow-up CRC patients who were still alive approximately 3 y after surgery. We also observed that beneficial bacteria dramatically decreased in CRC patients that recidivated or died after surgery. This revealed that important bacteria might be associated with prognosis.ConclusionsThe fecal bacterial diversity was diminished in CRC patients compared with that in healthy individuals. Enrichment and depletion of several bacterial strains associated with carcinomas and inflammation were detected in CRC samples.Fusobacteriummight be a potential biomarker for early screening of CRC in Chinese or Asian populations. In summary, this study indicated that fecal microbiome-based approaches could be a feasible method for detecting CRC and monitoring prognosis post-surgery.
CPEB2 m6A Methylation Regulates BTB Permeability via Affecting Splicing Factor SRSF5 Stability
Authors: Zhang Mengyang , Yang Chunqing , Liu Xiaobai , Ruan Xuelei , Wang Di , Liu Yunhui , Cai Heng , Zheng Jian , Shao Lianqi , Wang Ping , Li Zhen , Yu Bo , Xue Yixue 
Published: November 2020

AbstractThe existence of the blood tumor barrier (BTB) severely hinders the delivery of anti-tumor drugs to gliomas, affecting the targeted therapeutic effects of drugs. Therefore, BTB selective opening has become a hot spot for glioma treatment. This study found that the up-regulated METTL3 and IGF2BP3 in GECs increase the stability of CPEB2 mRNA through m6A methylation of CPEB2 mRNA; CPEB2 binds and increases the stability of splicing factor SRSF5 mRNA; SRSF5 promotes the ETS1 exon inclusion; P51-ETS1 promotes the transcriptional expression of tight junction related proteins ZO-1, occludin and claudin-5, regulating BTB permeability. CPEB2, SRSF5 and P51-ETS1 alone or in combination can effectively enhance the role of Dox in promoting glioma cell apoptosis through BTB. The results of this study provide a new theoretical and experimental basis for the molecular regulation of BTB from the perspective of epigenetics, as well as new ideas for the comprehensive treatment of glioma.
Prophage-encoded small protein YqaH counteracts the activities of the replication initiator DnaA inBacillus subtilis
Authors: Ventroux Magali , Noirot-Gros Marie-Francoise 
Published: November 2020

AbstractBacterial genomes harbor cryptic prophages that are mostly transcriptionally silent with many unannotated genes. Still, cryptic prophages may contribute to their host fitness and phenotypes. InB. subtilis, theyqaF-yqaNoperon belongs to the prophage elementskin, and is tightly repressed by the Xre-like repressorsknR. This operon contains several short open reading frames (smORFs) potentially encoding small-sized proteins. The smORF-encoded peptide YqaH was previously reported to bind to the replication initiator DnaA. Here, using a yeast two-hybrid assay, we found that YqaH binds to the DNA binding domain IV of DnaA and interacts with Spo0A, a master regulator of sporulation. We isolated single amino acid substitutions in YqaH that abolished interaction with DnaA but not with Spo0A. Then, we studied inB. subtilisthe phenotypes associated with the specific loss-of-interaction with DnaA (DnaA-LOI). We found that expression ofyqaHcarrying DnaA-LOI mutations abolished the deleterious effects ofyqaHWT expression on chromosome segregation, replication initiation and DnaA-regulated transcription. When YqaH was induced after vegetative growth, DnaA-LOI mutations abolished the deleterious effects of YqaH WT on sporulation and biofilm formation. Thus, YqaH inhibits replication, sporulation and biofilm formation mainly by antagonizing DnaA in a manner that is independent of the cell cycle checkpoint Sda.
An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines
Authors: Quinlan Brian D. , He Wenhui , Mou Huihui , Zhang Lizhou , Guo Yan , Chang Jing , Peng Shoujiao , Ojha Amrita , Tavora Rubens , Parcells Mark S. , Luo Guangxiang , Li Wenhui , Zhong Guocai , Choe Hyeryun , Farzan Michael 
Published: November 2020

ABSTRACTThe SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates viral entry into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independently folded 197-amino acid fragment of the 1273-amino acid S-protein protomer. The RBD is the primary SARS-CoV-2 neutralizing epitope and a critical target of any SARS-CoV-2 vaccine. Here we show that this RBD conjugated to each of two carrier proteins elicited more potent neutralizing responses in immunized rodents than did a similarly conjugated proline-stabilized S-protein ectodomain. Nonetheless, the native RBD expresses inefficiently, limiting its usefulness as a vaccine antigen. However, we show that an RBD engineered with four novel glycosylation sites (gRBD) expresses markedly more efficiently, and generates a more potent neutralizing responses as a DNA vaccine antigen, than the wild-type RBD or the full-length S protein, especially when fused to multivalent carriers such as anH. pyloriferritin 24-mer. Further, gRBD is more immunogenic than the wild-type RBD when administered as a subunit protein vaccine. Our data suggest that multivalent gRBD antigens can reduce costs and doses, and improve the immunogenicity, of all major classes of SARS-CoV-2 vaccines.
Growth and business cycle in Argentina. A long-run approach, 1870–2015
Authors: Dolores Gadea María , Sanz-Villarroya Isabel 
Published: November 2020

Purpose
The purpose of this study is to focus deeply on the short term to explain the relative long-term evolution of the Argentinian economy in the long and the short term.

Design/methodology/approach
The study of the long-term evolution of the Argentine economy and identifying the moment in which it began to lose ground compared to other developed economies, such as Australia and Canada, constitutes the central axis of the historiography of this country. However, an additional problem presented by the Argentine economy is its high volatility. For this reason, the long term should be influenced by the short term, an issue that requires a more detailed study of the cyclical behavior and a deep analysis of the relationship between the long and the short term.

Findings
The results obtained point to a cyclical development that influences the long-term evolution and, therefore, explains Argentina’s convergence process with Australia and Canada. Frequent deep busts and short booms characterize the Argentine cycle, offsetting its long-term growth potential.

Originality/value
Although the long term has been profusely studied in Argentina, the short term has not been analyzed to the same extent, which is surprising given the extreme volatility of this economy (Prebisch, 1950). The studies performed on economic cycles have always been partial, disconnected from the long term and carried out without much technical rigor.
Higher education between massification and quality
Authors: Noui Rabah 
Published: November 2020

PurposeThe purpose of this paper is to examine how the policy of massification as a characteristic of the higher education system influences the quality of education? and what higher education model can the authors adopt to reconcile flow and quality?Design/methodology/approachThe methodology adopted is based on a questionnaire survey of a population of young graduates divided between graduates with a conventional license and LMD license, either in the process of preparing for a diploma or in unemployment or work. But also, the qualitative dimension which, although secondary in this survey, the authors mobilized it through the analysis of open questions relating to the perceptions and representations that young graduates have of their situations.FindingsThe higher education reforms are perceived differently by higher education actors. The results found show that university massification has had the opposite effect by training graduates doomed to unemployment and expatriation.Research limitations/implicationsThe sample for this study is very limited, the results of this finding cannot be generalized to the entire university student as a whole.Originality/valueThis study emphasizes the duality of flow and quality in higher education. The authors have shown the different perceptions of stakeholders in higher education and that despite the multiple reforms of this system the authors still cannot find the best model.
I am engaged, therefore my students are satisfied! Unleashing the role of teachers' interaction and sensitivity based on self-determination perspective
Authors: Bilal Ahmad Raza , Fatima Tehreem , Bin Dost Khyzer , Imran Muhammad Kashif 
Published: November 2020

PurposeStudents' satisfaction is termed as their subjective evaluation of the fulfillment of expectations and pleasure experienced from the teaching services. This study intends to examine the role of teachers' work engagement in inculcating students' satisfaction from their teachers taking a self-determination perspective. It moreover highlights the underlying mechanisms of teacher–student interaction and teachers' sensitivity.Design/methodology/approachWe used 278 valid and matched responses from teachers and students of higher secondary/intermediate/degree colleges operating in Pakistan through multi-stage sampling. The data were gathered in three waves and multiple mediation analysis was conducted using PROCESS model 4 to analyze the data and infer results.FindingsThe results revealed that college teachers' work engagement (i.e. vigor, dedication and absorption) is required to create their willingness and motivation to invest in effective pedagogical decisions and inculcate students' satisfaction. This engagement, in turn, improves their interaction with students and makes them more sensitive in meeting the needs of students that causes students to have satisfying educational experiences.Originality/valueThis research has taken a unique standpoint of considering teachers' engagement as a precursor of students' satisfaction, in contrast to the prior focus on assessing the role of institutional dynamics, demographics and teachers' competence. It has also unraveled the role of teachers' sensitivity and student–teacher interaction in the above-mentioned association based on self-determination theory (SDT). Moreover, it has emphasized the teaching dynamics and its outcomes in the college sector instead of the much-examined university and school settings.
Internal control, risk and Sharīʿah non-compliant income in Islamic financial institutions
Authors: Hanefah Mustafa Mohd , Kamaruddin Muhammad Iqmal Hisham , Salleh Supiah , Shafii Zurina , Zakaria Nurazalia 
Published: November 2020

Purpose
The existence of internal control for Sharīʿah-compliance promotes reasonable assurance that the Islamic financial institution’s (IFI’s) objectives are achieved in the following categories, namely, the effectiveness and efficiency of operations, the reliability of financial reporting and the level of compliance with applicable laws and regulations, as well as accounting and auditing standards. Sharīʿah non-compliant income (SNCI) is an important issue in IFIs’ operations. Thus, the purpose of this paper is to identify issues related to governance and internal control of SNCI in selected IFIs in Malaysia.

Design/methodology/approach
This research uses a case study approach to gather data on the measures of governance and risk management in relation to the internal control for SNCI in IFIs. Interviews were conducted with officers of the Sharīʿah and internal audit departments on internal control practices regarding SNCI.

Findings
Regulator’s guidelines on SNCI are simple and brief, lacking rigour in terms of governance, risk management and audit procedures. The section on SNCI is only a brief statement within the Bank Negara Malaysia’s Guidelines on Financial Reporting for Islamic Banking Institutions and also in the Operational Risk Integrated Online Network system operated by IFIs. Most of the respondents in the interviews suggested that there should be a proper guideline in determining the classification of SNCI. Second, although IFIs have established the purification account to manage SNCI, the real practice varies from one IFI to another. Third, although there are supposedly documented procedures established in relation to management and administration of SNCI, the following events still occur in practice, namely, no authorisation from the Sharīʿah Committee (SC) on various types of income channelled to the SNCI account; unauthorised use of SNCI for other purposes; SNCI not being reported in the annual financial reports; and distribution of SNCI prior to obtaining the SC’s consent. Fourth, there is an absence of Sharīʿah risk assessment conducted on operational risk by IFIs to identify any potential Sharīʿah non-compliant event.

Research limitations/implications
This research contributes to the importance of Islamic corporate governance theory and Sharīʿah risk management, as well as strengthening the case for reporting SNCI to shareholders. It also contributes to the body of knowledge on the capability of the management in managing the internal control system of IFIs’ SNCI.

Originality/value
A new internal control assessment matrix is proposed for Sharīʿah-compliance in IFIs.
Accessible services for smart societies in learning
Authors: Altinay Fahriye , Ossiannilsson Ebba , Altinay Zehra , Dagli Gokmen 
Published: November 2020

PurposeThis research study aims to evaluate the capacity and sustainability of an accessible society as a smart society and services with the help of MOOCs and assistive technologies within the learning analytics framework.Design/methodology/approachQualitative research was employed in this research that interview forms were conducted to get data from 60 participants. Thematic analysis was used to analyze data.FindingsResearch results revealed that MOOCs and assertive technologies are crucial for smart society and opens a map for open pedagogy. Accessible media, services and applications in smart societies are key elements for disabled people lives.Research limitations/implicationsResearch is limited to numbers of research participants in northern part of Cyprus.Practical implicationsEstablishing strategies and policies for the smart and accessible society and services are intensified need for the disabled people within the framework of learning analytics.Social implicationsAssistive technologies become medium of facilitating accessible and smart society and services for everyone.Originality/valueEducation plays a great role to enrich services of societies in order to create inclusive efforts to the life of disabled people. United Nations Educational Scientific and Cultural Organizations (UNESCO) underline the main theme of making inclusive and equitable quality education and promoting lifelong learning opportunities for all. In this respect, accessibility, inclusiveness, equity, equality, quality for lifelong learning are main components to foster accessible and smart society for everyone. Integrating the importance of learning analytics creates a value for understanding of being smart society.
Implementation of 3D printing and the effect on decision making in logistics management
Authors: Hecker Stefan 
Published: November 2020

PurposeFrom a synthesis of literature, the purpose of this paper is to present a conceptual service development methodology showing the impact of 3D printing as a disruptive technology to the service portfolio. The methodology is designed to support practitioners and academics in better understanding the impact of disruptive technologies may have to the service portfolio and participate in the technology.Design/methodology/approachA literature review is conducted and based on these findings a conceptual framework has been developed.FindingsThe design of a methodology for the development of 3D printing services is used to evaluate the disruption potential of 3D printing and to implement the technology in the service portfolio of a logistics service provider. The disruption potential of 3D printing influences a logistics manager by make to order decisions. In addition, it could be proven the service portfolio was diversified.Research limitations/implicationsLiterature directly dealing with technology-based service development for decision making in logistics management is rare and thus the methodology is built on insights, compiled from the distinct research areas. Further research should be performed on this nascent topic.Practical implicationsLogistics service providers may use the developed methodology to revise their service portfolio by the consideration of disruptive technologies, in order to reduce strategic misdecisions regarding the range of services.Originality/valueThis paper looks specifically at decision making for implementing disruptive technologies to the service portfolio.
Effects of fiscal credibility on sovereign risk: evidence using comprehensive credit rating measures
Authors: Montes Gabriel Caldas , Costa Julyara 
Published: November 2020

PurposeSince sovereign ratings provided by credit rating agencies (CRAs) are a key determinant of the interest rates a country faces in the international financial market and once sovereign ratings may have a constraining impact on the ratings assigned to domestic banks or companies, some studies have focused on identifying the determinants of sovereign credit risk assessments provided by CRAs. In particular, this study estimates the effect of fiscal credibility on sovereign risk using four different comprehensive credit rating (CCR) measures obtained from CRAs' announcements and two different fiscal credibility indicators.Design/methodology/approachWe build comprehensive credit rating (CCR) measures to capture sovereign risk. These measures are calculated using sovereign ratings, the rating outlooks and credit watches issued by the three main credit rating agencies (S&P, Moody's and Fitch) for long-term foreign-currency Brazilian bonds. Based on monthly data from 2003 to 2018, we use different econometric estimation techniques in order to provide robust results.FindingsThe results indicate that fiscal credibility exerts both short- and long-run effects on sovereign risk perception, and macroeconomic fundamentals are important long-run determinants.Practical implicationsSince fiscal credibility reflects the government's ability to maintain budgetary balance and sustainable public debt, the government should keep its commitment to responsible fiscal policies so as not to deteriorate expectations formed by financial market experts about the fiscal scenario and, thus, to achieve better credit assessments issued by CRAs with respect to sovereign debt bonds. Sovereign credit rating assessment is a voluntary practice. It is up to the country whether they want to apply for a rating assessment or not. Thus, without a sovereign rating, one must find an alternative to measure the sovereign risk of a country. In this sense, an important practical implication that this study provides is that fiscal credibility can be used as a leading indicator of sovereign risk perceptions obtained from CRAs or even as a proxy for sovereign risk.Originality/valueThis paper is the first to verify how important the expectations of financial market experts in relation to the fiscal effort required to keep public debt at a sustainable level (i.e. fiscal credibility) are to sovereign risk perception of credit rating agencies. In this sense, the study is the first to address this relation, and thus it contributes to the literature that seeks to understand the determinants of sovereign ratings in emerging countries.
Enhancing the effects of university education for sustainable development on social sustainability: the role of social capital and real-world learning
Authors: Rey-Garcia Marta , Mato-Santiso Vanessa 
Published: November 2020

Purpose
The purpose of this paper is to understand the roles that social capital and real-world learning may play in enhancing the effects of university education for sustainable development (ESD) on social sustainability.

Design/methodology/approach
A conceptual framework that identifies the plausible effects of university ESD on social sustainability along three outcome dimensions (think-act-leverage), broadening desirable program learning outcomes and proposing enabling roles for social capital and real-world learning, is substantiated and validated through qualitative insights from a focus group. The framework serves to structure a survey to alumni of a postgraduate program in sustainability (2011–2018). Hierarchical clustering analysis is used to identify differences in perceived, sustainability-related effects of the program on direct beneficiaries and their relationship with stakeholders in their communities.

Findings
Implementation of real-world learning in partnership with organizations in the community that actively involves alumni not only extends desirable effects beyond individual program learning outcomes and outside the academia but may also renew them over time.

Practical implications
University administrators should foster the creation of new social capital of students and alumni and their commitment with service learning and other credit-bearing opportunities as actionable enablers to enhance the social sustainability effects of university ESD.

Originality/value
The paper contributes to a dual theoretical and empirical void related to the effects of university ESD on the social dimension of sustainability through the proposal of a conceptual framework and quantitative assessment of the dynamic effects of university ESD at the local level.