bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Adverse Events of Immune Checkpoint Inhibitors in Oncology Patients: A Systematic Review and Meta-Analysis
Authors: Vialli Nso Nso , Antwi-Amoabeng Daniel , Beutler Bryce D. , Ulanja Mark B. , Ghuman Jasmine , Hanfy Ahmed , Nimo-Boampong Joyce , Atanga Sirri , Doshi Rajkumar , Enoru Sostanie , Gullapalli Nageshwara 
Published: June 2020

AbstractBackgroundImmune checkpoint inhibitors (ICIs) are novel therapeutic agents used for various types of cancer. ICIs have revolutionized cancer treatment and improved clinical outcomes among cancer patients. However, immune-related adverse effects of ICI therapy are common. Cardiovascular immune-related adverse events (irAEs) are rare but potentially life-threatening complications. We aimed to estimate the incidence of cardiovascular irAEs among patients undergoing ICI therapy for various malignancies.MethodsWe conducted this systematic review and meta-analysis by searching PubMed, Cochrane CENTRAL, Web of Science, and SCOPUS databases for relevant interventional trials reporting cardiovascular irAEs. We performed a single-arm meta-analysis using OpenMeta [Analyst] software of the following outcomes: myocarditis, pericardial effusion, heart failure, cardiomyopathy, atrial fibrillation, myocardial infarction, and cardiac arrest. We assessed the heterogeneity using the I2test and managed to solve it with Cochrane’s leave-one-out method. The risk of bias was performed with the Cochrane’s risk of bias tool.ResultsA total of 26 studies were included. The incidence of irAEs follows: myocarditis: 0.5% (95% CI [0.1%-0.9%]); pericardial effusion: 0.5% (95% CI [0.1%-1.0%]); heart failure: 0.3% (95% CI [0.0%-0.5%]); cardiomyopathy: 0.3% (95% CI [-0.1%-0.6%]); atrial fibrillation: 7.6% (95% CI [1.0%-14.1%]); myocardial infarction: 0.4% (95% CI [0.0%-0.7%]); and cardiac arrest: 0.4% (95% CI [0.1%-0.8%]).ConclusionThe most common cardiovascular irAEs were atrial fibrillation, myocarditis, and pericardial effusion. Although rare, data from post market surveillance will provide estimates of the long-term prevalence and prognosis in patients with ICI-associated cardiovascular complications.
Systematic characterization of somatic mutation-mediated microRNA regulatory network perturbations
Authors: Hua Xu , Li Yongsheng , Guo Li , Xu Min , Qi Dan , Huang Jason H. , Bhat Akshay , Zhou Yunyun , Wu Erxi , Yi S. Stephen 
Published: June 2020

AbstractSomatic mutations are a major source of cancer development. Many driver mutations have been identified in protein coding regions. However, the function of mutations located in microRNAs (miRNAs) and their target binding sites along the human genome remains largely unknown. Here, we built comprehensive cancer-specific miRNA regulatory networks across 30 cancer types to systematically analyze the effect of mutations on miRNA related pathways. 3,518,261 mutations from 9,819 samples were mapped to miRNA-gene interactions (mGI), and mutations in miRNAs versus in their target genes show a mutually exclusive pattern in almost all cancer types. Using a linear regression method, we further identified 89 driver mutations in 14 cancer types that can significantly perturb miRNA regulatory networks. We find that driver mutations play their roles by altering RNA binding energy and the expression of target genes. Finally, we demonstrate that mutated driver gene targets are significantly down-regulated in cancer and function as tumor suppressors during cancer progression, suggesting potential miRNA candidates with significant clinical implications. We provide this data resource (CanVar-mGI) through a user-friendly, open-access web portal. Together, our results will facilitate novel non-coding biomarker identification and therapeutic drug design.
The Impact of Management on Hospital Performance
Authors: Asaria Miqdad , Gershlick Benjamin , McGuire Alistair , Street Andrew 
Published: June 2020

AbstractThere is a prevailing popular belief that expenditure on management by healthcare providers is wasteful, diverts resources from patient care, and distracts medical and nursing staff from getting on with their jobs. There is little existing evidence to support this narrative or counter-claims. We explore the relationship between management and public sector hospital performance using a fixed effects empirical econometric specification on a panel data set consisting of all 129 non-specialist acute National Health Service (NHS) hospitals in England for the financial years 2012/13 to 2018/19. Measures of managerial input and quality of management practice are constructed from NHS Electronic Staff Records and NHS Staff Survey data. Hospital accounts and Hospital Episode Statistics data are used to construct five measures of financial performance and of timely and high quality care. We find no evidence of association either between quantity of management and management quality nor directly between quantity of management and any of our measures of hospital performance. However, there is some evidence that higher quality management is associated with better performance. NHS managers have limited discretion in performing their managerial functions, being tightly circumscribed by official guidance, targets, and other factors outside their control. Given these constraints, our findings are unsurprising.
CEO’s with global experience and outward foreign direct investment: a contextualized analysis of Chinese firms
Authors: Sun Kai , Fung Hung-Gay , Zeng Yuping , Qiao Penghua 
Published: June 2020

PurposeThis paper aims to examine the effect of chief executive officers (CEOs’) global experience (GE) on the Chinese firms’ outward foreign direct investment (OFDI) and provides new insights on how CEOs’ foreign study and education experiences may affect firms’ OFDI. Further, this paper examines whether CEO power and state ownership have a positive moderating effect on the relationship between CEOs’ GE and firms’ OFDI.Design/methodology/approachThis study used panel data of Chinese manufacturing companies in 2007-2016 to examine different hypotheses. The authors tested them using a zero-inflated negative binomial regression model to shed light on the effect of CEOs’ GE on the firms’ OFDI.FindingsThis study found that CEOs’ GE generally promotes Chinese firms’ OFDI. CEOs’ foreign study experience has a stronger effect than foreign education experience. Further, CEO power and state ownership have a positive moderating effect on the relationship between CEOs’ GE and firms’ OFDI.Research limitations/implicationsThe findings have two important implications for managers and policy-makers. First, globally experienced CEOs are vital for firms to succeed in today’s highly competitive global environment. Second, CEO power is important in firms’ OFDI decision-making.Originality/valueThe authors use path dependency and upper echelons theories to show that GE, particularly foreign study experience, enables CEOs to take advantage of available resources in the market and institutional environment to create a path for the firm to expand globally.
Review of carbon footprint assessment in textile industry
Authors: Zhang Jin , Qian Xiaoming , Feng Jing 
Published: June 2020

Purpose
Under the global climate change, carbon footprint has become a hot issue at home and abroad. However, there is no consensus on the concept, measurement and application of carbon footprint.

Design/methodology/approach
In this paper, first, the concept and connotation of carbon footprint are reviewed; then, different methods of carbon footprint measurement are compared, and it is found that “bottom-up” life cycle assessment and “top-down” input–output analysis are applicable to different research scales.

Findings
Finally, the problems in the process of carbon footprint assessment in textile industry are analyzed and further research directions are proposed.

Originality/value
Analyzed and further research directions are proposed.
Multi-objective mathematical model based on fuzzy hybrid multi-criteria decision-making and FMEA approach for the risks of oil and gas projects
Authors: Khalilzadeh Mohammad , Balafshan Rose , Hafezalkotob Ashkan 
Published: June 2020

Purpose
The purpose of this study is to provide a comprehensive framework for analyzing risk factors in oil and gas projects.

Design/methodology/approach
This paper consists of several sections. In the first section, 19 common potential risks in the projects of Pars Oil and Gas Company were finalized in six groups using the Lawshe validation method. These factors were identified through previous literature review and interviews with experts. Then, using the “best-worst multi-criteria decision-making” method, the study measured the weights associated with the performance evaluation indicators of each risk. Consequently, failure mode and effects analysis (FMEA) and the grey relational analysis (GRA)-VIKOR mixed method were used to rank and determine the critical risks. Finally, to assign response strategies to each critical risk, a zero-one multi-objective mathematical programming model was proposed and developed Epsilon-constraint method was used to solve it.

Findings
Given the typical constraints of projects which are time, cost and quality, of the projects that companies are often faced with, this study presents the identified risks of oil and gas projects to the managers of the oil and gas company in accordance with the priority given in the present research and the response to each risk is also suggested to be used by managers based on their organizational circumstances.

Originality/value
This study aims at qualitative management of cost risks of oil and gas projects (case study of Pars Oil and Gas Company) by combining FMEA, best worst and GRA-VIKOR methods under fuzzy environment and Epsilon constraints. According to studies carried out in previous studies, the simultaneous management of quantitative and qualitative cost of risk of oil and gas projects in Iran has not been carried out and the combination of these methods has also been innovated.
Fueling knowledge management processes in Chinese higher education institutes (HEIs): the neglected mediating role of knowledge worker satisfaction
Authors: Sahibzada Umar Farooq , Jianfeng Cai , Latif Khawaja Fawad , Sahibzada Hassam Farooq 
Published: June 2020

PurposeConstructed upon knowledge-based view, the study examines the influence of internal marketing on knowledge management processes and the indirect association of knowledge management processes with organizational performance through mediating role of knowledge worker satisfaction.Design/methodology/approachThis study used a sample frame of 536 academic and administrative employees from higher education institutions in China; structural equation modeling was performed using Smart PLS 3.2.8.FindingsThe outcome reveals that internal marketing has a significant impact on knowledge management processes. The results revealed a direct insignificant impact of knowledge management processes on organizational performance; the study found full mediation of knowledge worker satisfaction on the linkage between knowledge management processes and organizational performance.Practical implicationsOutcomes of this research strengthen the universities’ experience of knowledge management and recommend how academics and administrators of higher education institute can value knowledge worker satisfaction, which in turn improves organizational performance.Originality/valueAlthough, there is an increased significance of knowledge management in higher education institutions, there is a lack of research that examines the enabling factors and outcomes of knowledge management practices. The present study is one of the first studies to ascertain the relationship of internal marketing, knowledge management processes, knowledge worker satisfaction and organizational performance. This is one of the initial research studies that not only empirically examines the interrelationships among these variables but also enlightens insights into the current literature by instantaneous investigation of the mediating role of knowledge worker satisfaction.
Healthcare service users as resource integrators: investigating factors influencing the co-creation of value at individual, dyadic and systemic levels
Authors: Virlée Justine Brigitte , Hammedi Wafa , van Riel Allard C.R. 
Published: June 2020

PurposePatients, when using healthcare services, (co)create value by integrating their own resources with those of a range of stakeholders. These resource integration activities, however, require different types of skills and effort from the patients, and different types of interactions with stakeholders, while also having different effects on patients' well-being. The purpose of the present study is to develop a better understanding of why some patients are better able or willing to perform resource integration activities that impact their well-being. To reach this objective, barriers and facilitators of these activities in their interactions with various stakeholders were identified.Design/methodology/approachThe study uses a multiple case study design. Individual patients having received a lung transplant, together with their entourage (family, medical professionals, other patients) each represent a case. In-depth interviews were conducted with the patients and with various categories of stakeholders in their service delivery network who were relevant to their experience and with whom they integrated their resources.FindingsThe study identifies three levels on which barriers and facilitators of the resource integration process occur: the individual, relational and systemic level. Factors on these levels affect different aspects of the process.Originality/valueThis study takes a systems perspective and investigates how various systemic factors and stakeholders conduce or inhibit healthcare service users to perform resource integration activities, especially focusing on those activities that strongly affect their well-being.
Translational mechanisms in business model design: introducing the continuous validation framework
Authors: Corbo Leonardo , Mahassel Shadi , Ferraris Alberto 
Published: June 2020

PurposeThis paper aims at proposing knowledge translation as an element of business model design that can support entrepreneurs in achieving alignment and collaboration between entrepreneurial teams and external stakeholders.Design/methodology/approachThe conceptual model presented in the paper is developed from the literature review and draws mainly on two streams of work as follows: first, the contributions related to the lean start-up methodology initially developed by Blank and Ries and second, the work of Osterwalder and Pigneur on business models and its subsequent developments. In addition, we draw on key insights from the entrepreneurship and organizational learning literature, such as discovery-driven planning and disciplined entrepreneurship.FindingsThe continuous validation framework (CVF) is introduced, posing the attention on underlining knowledge-translation mechanisms to decode complex concepts related to new venture creation.Originality/valueThe authors propose a new framework (the CVF) as an effective translational tool because it is a visual diagram that allows entrepreneurs to translate complex and technical ideas into a format that is more understandable for external audiences. Additionally, for each step of the CVF, specific translational mechanisms are defined and discussed, as each stage of the CVF presents specific translational challenges that result in outcomes that differ from stage to stage.
What Was Parliamentary Reporting? A Study of Aims and Results in the London Daily Newspapers, 1780–96*
Authors: Harris Ian 
Published: June 2020

AbstractThe nature of these newspaper reports – that is, the character of their principal content – has never been studied, despite its obvious importance and, as we shall see, its marked differences from our Hansard. This article relates their nature to a vital feature of parliamentary leadership, the ability to lead the argument in debate. The practical reasoning in parliamentary deliberation and justification, especially what speakers contributed towards the outcome or ‘the sense of the debate’, predominated in these reports. This implied a need for reporters to concentrate on the ‘substance’ of speeches and their bearing on the motion. One result was that speeches which were judged to define or develop arguments pro and con were treated at length, the defining speeches most extensively and others in proportion to what they added. Conversely, speeches which reiterated known positions or which were irrelevant to the arguments in hand were omitted or downplayed, even if they were important in some other way, while whole debates which added little to ongoing discussion could be treated quite briefly. But if being a front bencher did not guarantee coverage, being a back bencher was no bar: the criterion was the importance of a speaker's contribution, while the manner of coverage accented what was contributed. The reporters’ concerns emphasized debates that promised significant change in matters of national importance, but gave relatively little attention to recurrent or localised business as such. Their writing – they were known as debate writers or news‐writers – was interpretation answering to evaluative and selective criteria rather than a record in a simple sense. Their work is not to be understood in the same terms as a modern Hansard, and in particular not as a defective Hansard, but rather is such that it requires further work on a wide range of new research questions if it is to be understood to best effect, a requirement which suggests a need to study it critically before using it as source material.
The chemical composition of barley grain (Hordeum vulgare L.) landraces from the Canary Islands
Authors: Panizo‐Casado María , Déniz‐Expósito Pilar , Rodríguez‐Galdón Beatriz , Afonso‐Morales Desirée , Ríos‐Mesa Domingo , Díaz‐Romero Carlos , Rodríguez‐Rodríguez Elena M. 
Published: June 2020

AbstractThe proximate composition, total phenolics, antioxidant activity, minerals, and trace elements were determined in 42 barley landraces in order to highlight their nutritional potential and promote their cultivation. Two‐row barley landraces had a higher average content of starch, protein, total phenolic compounds, and iron, when compared with six‐row ones that presented higher mean ash and fiber concentrations. Additionally, the six‐row barley landraces with strongly pigmented grains had lower zinc and manganese and higher protein mean concentrations than the whitish or lightly pigmented barley landraces. Factor analysis and linear discriminant analysis were used to correctly differentiate samples according to type of barley (landrace or commercial) and number of rows. In general, all the parameters varied considerably among the barley landraces analyzed, but some barley landraces could be emphasized according to fiber, minerals, and phenolic antioxidants. There were important differences in the mean values in all the chemical parameters according to the island of origin of the barley grains. The application of linear discriminant analysis was also a useful tool to differentiate all the barley landraces with six rows according to the island of origin.Practical ApplicationBarley is a versatile cereal that can be used for human and animal feed, brewing, and as biodiesel. From the nutritional point of view, barley is rich in starch, protein, dietary fiber and minerals, as well as antioxidant compounds and vitamins. The landraces analyzed in this study have remained intact for the last 900 years, which gives opportunity to genome of these barley landraces to evolve some very specific traits. The physicochemical characterization of these local landraces carried out by us could be very useful as a source of new quality in breeding programs.
Comparison of phenolics, antioxidant, and antiproliferative activities of two Hypsizygus marmoreus varieties
Authors: Xu Qiuxiong , Wang Hong , Li Tong , Chen Ling , Zheng Bisheng , Liu Rui Hai 
Published: June 2020

AbstractPhenolics, antioxidant activities, and antiproliferative properties of brown Hypsizygus marmoreus (brown HM) and white Hypsizygus marmoreus (white HM) were compared. The results showed that the contents of (+)‐catechin, gallic acid, and protocatechuic acid of brown HM were higher than those of white HM. Moreover, brown HM had greater cellular antioxidant activity (CAA), peroxyl radical scavenging capacity (PSC), and oxygen radical absorbance capacity (ORAC) values than white HM, which demonstrated that brown HM presented a stronger antioxidant capacity. Both of brown HM and white HM showed remarkable antiproliferative activities against HepG2 cells and brown HM was proven to be the more effective. The flow cytometry results revealed that both of brown HM and white HM could induce G1 arrest and cell apoptotics in a dose‐dependent manner. In addition, CyclinD1, CDK4, and Bcl‐2 mRNA expression levels were downregulated with the treatment of brown HM or white HM. Taken together, our study revealed that brown HM afforded better antioxidant and antiproliferative activities than white HM and laid the foundation for potential application of Hypsizygus marmoreus as source of nutraceuticals and functional food products.Practical ApplicationA systematic assessment of the potential differences of phenolics, antioxidant, and antiproliferative activities between different Hypsizygus marmoreus varieties was carried out in the present study. Furthermore, our findings would present possible antiproliferative mechanism of extracts of different Hypsizygus marmoreus varieties, which may provide theoretical basis for further development and utilization of Hypsizygus marmoreus.
Comparison of the efficacy and safety of tofacitinib and peficitinib in patients with active rheumatoid arthritis: A Bayesian network meta‐analysis of randomized controlled trials
Authors: Lee Young Ho , Song Gwan Gyu 
Published: June 2020

AbstractObjectivesThe relative efficacy and safety of tofacitinib and peficitinib were assessed in patients with rheumatoid arthritis (RA) with an inadequate response to disease‐modifying antirheumatic drugs (DMARDs).MethodWe performed a Bayesian network meta‐analysis to combine direct and indirect evidence from randomized controlled trials (RCTs) to examine the efficacy and safety of tofacitinib and peficitinib in combination with DMARDs in patients with an inadequate response to DMARDs.ResultsNine RCTs, including 3836 patients, met the inclusion criteria. Fifteen pairwise comparisons were performed, including six direct comparisons of seven interventions. Tofacitinib 10 mg+methotrexate (MTX) and peficitinib 150 mg+MTX were among the most effective treatments for patients with active RA with an inadequate DMARD response. The efficacy of tofacitinib 10 mg+MTX, peficitinib 150 mg+MTX or tofacitinib 5 mg+MTX tended to be higher than that of adalimumab+MTX. The ranking probability based on the surface under the cumulative ranking curve indicated that tofacitinib 10 mg+MTX had the greatest probability of being the best treatment to achieve the American College of Rheumatology 20 response rate, followed by peficitinib 150 mg+MTX, tofacitinib 5 mg+MTX, adalimumab+MTX, peficitinib 100 mg+MTX, and placebo+MTX. No significant differences were observed in the incidence of serious adverse events after treatment with tofacitinib+MTX, peficitinib+MTX, adalimumab+MTX, or placebo+MTX.ConclusionsIn patients with RA with an inadequate response to DMARDs, tofacitinib 10 mg+MTX and peficitinib 150 mg+MTX were the most efficacious interventions and were not associated with a significant risk of serious adverse events.