bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of endovascular patent foramen ovale closure: the first results of a Russian multicenter study
Authors: Ognerubov D. V. , Tereshchenko A. S. , Samko A. N. , Arutyunyan G. К. , Sivakova O. A. , Pevzner D. V. , Makeev M. I. , Balakhonova T. V. , Belopasova A. V. , Maksimova M. Yu. , Chuprina S. E. , Khodyakova E. P. , Kulesh A. A. , Mekhryakov S. A. , Shchekochikhin D. Yu. , Bogdanova A. A. , Merkulov E. V. 
Published: December 2020

Patent foramen ovale (PFO) is detectable in more than 25% of the adult population and is generally clinically insignificant. However, it can be a cause of paradoxical embolism in some cases. Randomized trials indicate that endovascular PFO closure in patients with a history of cryptogenic stroke is an effective method for the secondary prevention of catastrophic brain damage.Objective: to study the safety and efficiency of endovascular PFO closure in young patients with a history of cryptogenic stroke.Patients and methods. Sixty-two patients, including (22 males and 40 females) women, underwent percutaneous PFO closure in May 2018 to March 2020. The patients' mean age was 37.4±7.6 years. The inclusion criteria were a prior cryptogenic ischemic stroke lasting less than 12 months and PFO with a high risk for paradoxical embolism (PFO concurrent with atrial septal aneurysm or hypermobility; PFO, ≥2 mm size; the presence of the Chiari network and/or the Eustachian valve).Results and discussion. The technical success of the operation was achieved in all cases. In 50 (80.6%) patients, the right chamber of the heart was completely isolated from the left one in the first 3 months. During the first year, the atria were also completely isolated in 10 (16.1%) patients. A left-to-right shunt persisted in 2 (3.2%) patents 12 months later. Two patients were found to have main procedural complications: one had perioperative atrial fibrillation and the other had pseudoaneurysm formation at the puncture site.Conclusion. Endovascular PFO closure is a safe and effective operation for the secondary prevention of recurrent ischemic stroke. In our study, blood shunting through the PFO was stopped in 96.6% of patients at less than 6 months after surgery, which suggests that there is a rapid and effective reduction in the risk of paradoxical embolism.
The interaction of folate cycle enzyme genes and the risk of extrapyramidal side effects of antipsychotics
Authors: Zhilyaeva T. V. , Akimova E. V. , Blagonravova A. S. , Mazo G. E. 
Published: December 2020

Personalized medicine means the selection of therapy for patients, taking into account the assessment of genetic risk factors for side effects. A number of studies show that folate metabolism disorders, including single nucleotide polymorphisms (SNPs) in the genes of folate-metabolizing enzymes, are more frequently detected in schizophrenic patients than in the general population. The role of SNPs of the key folate cycle enzymes in developing the extrapyramidal side effects of antipsychotics has not yet been studied, although there is evidence of their association with other movement disorders.Objective: to analyze the association between the carriage of SNP alleles of MTHFR 677C>T, MTR 2756A>G, and MTRR 66A>G and the severity of extrapyramidal side effects of antipsychotics in patients with schizophrenia.Patients and methods. The investigation included 61 patients with schizophrenia (according to the criteria for ICD-10 Code F20). All the patients took antipsychotics for at least 7 hospital days were examined using real-time polymerase chain reaction (PCR) with allele-specific primers, followed by detection for the carriage of SNP alleles of MTHFR 677C>T, MTR 2756A>G, and MTRR 66A>G. The standardized Simpson–Angus scale (SAS) was used to evaluate the severity of extrapyramidal symptoms; the PCR test results were unknown during their examination.Results and discussion. In the patients carrying a low-functional 677 T allele in the gene of the key folate cycle enzyme MTHFR, the severity of extrapyramidal side effects of antipsychotics was statistically significantly higher than in the carriers of the wild-type genotype: 13.27±5.10 versus 9.84±6.03 SAS scores, respectively (t=-2.40; p=0.020). In addition, the carriage of the wild allele A of SNP in the MTRR 66A>G gene (F=3.83; p=0.0283; pcorr.=0.043) is associated with the severity of extrapyramidal symptoms. There was a direct moderate correlation of the number of risk alleles at two loci with the total SAS score (r=0.51; p=0.00017).Conclusion. The polymorphic allele of MTHFR 677T and the wild allele of MTRR 66A can be regarded as risk alleles for the development of extrapyramidal side effects of antipsychotics.
Pregnancy and epilepsy: focus on seizure frequency changes and obstetric complications. Progress in studies and lag in practice
Authors: Ivanova N. E. , Odintsova G. V. , Oleinik A. A. , Shchetinina A. M. 
Published: December 2020

Epilepsy is a common neurological disease that negatively affects all areas of life, with a need to take antiepileptic drugs (AEDs) for a long time and with a high incidence of side effects.Objective: to determine the main directions of studies dealing with the problem of pregnancy in epilepsy, by analyzing their results.Material and methods. Over past 10-year publications on pregnancy in epilepsy, their prospects for and prognostic significance for solving scientific and practical problems underwent an analytical review.Results and discussion. It was found that the risk for higher frequency of seizures was 15 times lower if the latter were controlled within 9–12 months before pregnancy. AED therapy noncompliance during pregnancy is the cause of relapses, increased seizure frequency, and status epilepticus. Changes in the blood concentrations of AED during pregnancy require therapeutic drug monitoring and correction of daily dosages of these drugs. The indication for caesarean section in epilepsy is a high perinatal and maternal risk. Breastfeeding in maternal epilepsy is indicated applying a personalized approach. Studying the predictors of changes in the frequency of seizures and improving pregravid preparation are promising areas for optimizing pregnancy outcomes in epilepsy.
Sustainable Tourism Concept to Revitalize Ocarina Area in Batam City, Indonesia
Authors: Cia Helen , Gunawan I Gusti Ngurah Anom , Murtiono Hendro 
Published: December 2020

The purpose of this research is to explore the concept of revitalizing the coastal tourism area with a sustainable tourism approach. Ocarina area is one of the tourist destinations in Batam city. Its strategic location is right in the center of Batam and is surrounded by several areas with different functions, among others there are housing (housing Regata, housing Monde Residence, housing Avante, Monde Signature housing, etc.), a school (Mondial school), a commercial area ( Pasir Putih shops, Mahkota Raya shops) and also the location of Ocarina area is close to the international ferry. The phenomenon that occurs in this tourist area has long been built and managed but has decreased visitors so that needs to be revitalized by using the concept of sustainable tourism. This strategic location is not accompanied by the success of the development of the Ocarina area as a public space that offers a variety of game facilities and culinary venues. The phenomenon that makes the need for revitalizing measures both physically and economically to make the Ocarina area can attract visitors to come and enjoy the facilities that are in it. The research method was a qualitative method of direct observation in the field. Analysis process is conducted to identify the problems that exist in the field today especially in the area of Ocarina Phase 1 so that the area of Ocarina Phase 2 can make Ocarina Phase 1 to be revitalized area and can be one of the sustainable tourism Batam city that can improve the economy of Batam city. Keywords: revitalization, sustainable tourism, visitor
Influence of the Primary Tumor Location on the Pattern of Synchronous Metastatic Spread in Patients with Stage IV Colorectal Carcinoma, According to the 8 th Edition of the AJCC Staging System
Authors: Alexandrescu Sorin Tiberiu , Anastase Diana Teodora , Grigorie Razvan Tudor , Zlate Cristian Andrei , Andrei Stefan , Costea Radu , Gramaticu Iulia Magdalena , Croitoru Adina Emilia , Popescu Irinel 
Published: December 2020

Background and Aims: The correlations between primary tumor location (right colon cancer – RCC, left colon cancer – LCC and rectal cancer – RC) and the incidence of metastatic sites are scarce and divergent. The current study is the first which compares the pattern of metastatic distribution (M1a: metastasis to one organ/site, excluding peritoneum; M1b: two or more metastatic sites; M1c: peritoneal metastases) between RCC, LCC and RC, respectively.
Methods: All patients operated for colorectal cancer (CRC) between January 2006 and December 2015 were analyzed to assess the primary tumor location, the presence and site of synchronous metastases. Univariate analysis determined the statistical significance of association between each CRC location and the metastatic pattern. Multinomial logistical regression model compared the prevalence of each metastatic pattern for each CRC location.
Results: Out of 5,107 patients, 1,318 (25.80%) had metastases on the moment of CRC diagnosis. There were no statistically significant association between the metastatic pattern and the patients’ gender (M1a, p=0.321; M1b, p=0.539; M1c, p=0.417, Chi-square) or patients’ age (p=0.616 Mann–Whitney U-test). RC had a significant higher relative risk for M1a (RR of 1.437, p=0.014) and a lower relative risk for M1c (RR of 0.564, p=0.001), compared to LCC. On the contrary, compared with LCC, the RCC showed a significant lower relative risk for M1a (RR of 0.673, p=0.006) and a higher relative risk for M1c (RR of 1.834, p=0.0001).
Conclusion. There is a strong correlation between the primary location of CRC and the pattern of the metastatic spread, with potential prognostic implications.
Statins and Risk of Cholangiocarcinoma: A Systematic Review and Meta-analysis
Authors: Wijarnpreecha Karn , Aby Elizabeth S , Ghoz Hassan , Cheungpasitporn Wisit , Lukens Frank J , Harnois Denise M , Ungprasert Patompong 
Published: December 2020

Background and Aims: The use of statins has been shown to be associated with a decreased risk of cholangiocarcinoma (CCA) in many studies although the results have been inconsistent. We conducted this systematic review and meta-analysis to further investigate this possible association by identifying all relevant studies and combining their results together.
Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through March 2020 to identify all studies that compared the risk of CCA among individuals who use statins with individuals who do not use statins. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results: A total of seven studies with 6,251,187 participants fulfilled the eligibility criteria and were included in this meta-analysis. The pooled analysis found a significantly decreased risk of CCA among individuals who use statins compared with individuals who do not use statins with the pooled odds ratio of 0.68 (95% CI: 0.52-0.89; I 2 96%).
Conclusions: The current systematic review and meta-analysis found a significant association between the use of statins and a decreased risk of CCA.
The Prevalence of HCV Infection and Risk Factors in a Hospital- Based Population Screening, a First Step to the Micro-Elimination of HCV Infection in Medical Institutions from Romania - Results of the HepC ALERT Study
Authors: Gheorghe Liana , Iacob Speranta , Csiki Irma Eva , Huiban Laura , Cojocaru Monica , Cojocariu Camelia , Nemteanu Roxana , Girleanu Irina , Sirli Roxana , Singeap Ana Maria , Pop Corina , Dumitrascu Dan L , Vadan Roxana , Iacob Razvan , Diculescu Mircea , Trifan Anca , Sporea Ioan , Gheorghe Cristian 
Published: December 2020

Background and Aims: Elimination of hepatitis C worldwide is more feasible if micro-elimination screening strategies are adopted. We aimed to screen hepatitis C virus (HCV) in specific high-risk populations in certain sub-regions of Romania and link them to antiviral treatment.
Methods: A multicenter prospective study was conducted among the hospitalized or ambulatory adult patients from March 2019 to March 2020 in more than 20 medical institutions from 4 Romanian cities (Bucharest, Iasi, Timisoara, Cluj-Napoca). A rapid diagnostic test for HCV diagnosis was performed to all admitted patients and the positive ones were sent to gastroenterology departments for confirming the active infection, staging and treatment prescription.
Results: In total, 25,141 subjects signed the informed consent and were consequently enrolled into the study. The prevalence of anti-HCV antibodies was 1.39% (95%CI: 1.25-1.54) and increased with the number of risk factors presented by one subject. There was a positive association between the presence of anti-HCV antibodies and female gender (p<0.001), rural area of residence (p<0.001), advanced age (p<0.001), as well as a negative association with the education level (p<0.001).
Conclusions: In a hospital-based screening micro-elimination program in Romania, HCV prevalence was lower than previously reported. This is a first step towards a cost-effective screening in a well-defined group of persons at risk and provides sufficient capacity to deliver access to HCV treatment and linkage to care in Romania.
What is the Impact of the Proportion of Solid Necrotic Content on the Number of Necrosectomies during EUS-Guided Drainage using Lumen-Apposing Metallic Stents of Pancreatic Walled-off Necrosis ?
Authors: Seicean Andrada , Pojoga Cristina , Mostean Ofelia , Bolboaca Sorana , Ilie Madalina , Rimbas Mihai , Gheorghiu Marcel , Lucaciu Laura , Bartos Adrian , Al Hajjar Nadim , Sandru Vasile , Constantinescu Gabriel , Seicean Radu 
Published: December 2020

Background and Aims: The fully-covered, lumen apposing metal stents are designed for one step placement, facilitating the direct endoscopic necrosectomy into the walled-off pancreatic necrosis. However, the prediction of the number of necrosectomy sessions in these patients is not known. This study evaluated the association between the proportion of solid necrotic material inside walled-off necrosis, as assessed during the endosonography placement of a lumen apposing metal stent, and the number of necrosectomies subsequently required.
Methods: Patients from three tertiary medical centers with symptomatic walled off pancreatic necrosis (pain, infection, gastric/biliary obstruction) at more than 4 weeks after onset of acute pancreatitis were retrospectively analysed. Proportion of solid necrotic debris was estimated during endosonography procedure of lumen apposing metal stents placement. Necrosectomy was performed when obstruction or inflammation occurred subsequently. Lumen apposing metal stents were removed after clearance of necrotic content.
Results: In 46 patients with successful lumen apposing metal stents placement, necrosectomy was performed in 39 patients (72.78%). Performance of 3 or more necrosectomies was significantly associated with more than 50% pancreatic necrosis (p=0.032), but not with walled-off pancreatic necrosis size or location. Necrotic infection during lumen apposing metal stents stenting was associated with hypoalbuminemia, but not with necrosectomy requirement. Clinical success after a median follow-up of 13.37 months was 87%.
Conclusions: Walled-off pancreatic necrosis with more than 50% solid necrotic content were associated with more necrosectomy procedures, requiering longer endoscopy time, intravenous sedations, and higher costs.
Використання кавітаційних ефектів в процесах екстрагування
Authors: Целень Богдан Ярославович , Гоженко Любов Петрівна , Радченко Наталія Леонідівна , Іваницький Георгій Костянтинович 
Published: December 2020

Представлено огляд традиційних і сучасних технологій екстрагування рослинної і тваринної сировини та інноваційних методів інтенсифікації процесів екстракції. Розглянуто три основні фактори які забезпечують інтенсифікацію процесів екстракції, а саме: збільшення питомої поверхні контакту фаз, підтримання високого потенціалу масопереносу, а також прискорення масопереносу через міжфазну поверхню. Серед них найбільш вагомим фактором інтенсифікації є прискорення внутрішнього масопереносу в структурі сировини. На цій лімітуючій стадії відбувається підведення розчинника до цільового компонента і подальша молекулярна дифузія розчиненої речовини через складну капілярно-пористу структуру до поверхні частинки. Показано, що сучасні інноваційні методи, спрямовані саме на заміну молекулярної дифузії в матриці сировини на конвективний масоперенос. Ефективність цих методів базується на ефектах кавітації, які розглядаються як основний фактор інтенсифікацій внутрішнього масопереносу в сировині. Обговорюються основні механізми кавітаційної дії, які сприяють прискорення внутрішнього масопереносу.
В статті особливу увага приділено роботі пульсаційних екстракторів, котрі ефективно застосовуються при екстрагуванні з грубо дисперсної сировини. Розглянуто конструкцію і принцип работи пульсаційного диспергатора-екстрактора, в якому для посилення кавітаційної ефектів дії вперше застосовано сопло Вентурі. До найбільш вагомих переваг нової конструкції віднесено можливість скорочення часу екстракції, максимальне вилучення цільових речовин, зменшення питомих енерговитрат та збільшення продуктивності, а також можливість одночасного проведення процесів змішування, екстракції, диспергування, гомогенізації, що дозволить в подальшому його застосування в різних промислових технологіях.
Impact of learning interventions on mathematics achievement among learners with hearing impairment
Authors: Kuku Olaotan Oladele , Adeniyi Samuel Olufemi 
Published: December 2020

There had been consistent concern and reports on the low achievement of learners with hearing impairment in mathematics with mixed observations about the ability and influence of learning environment of learners with hearing impairment. However, there are consensus that impactful teaching effort could aid in stimulating innovative approaches in teaching and learning of mathematics of learners particularly among learners with hearing impairment. This study seeks to appraise the impact of gamification and experiential learning on achievement in mathematics among learners with hearing impairment in Lagos State, Nigeria. The study population comprised learners with hearing impairment in Lagos State. Purposive and simple random sampling were used to select sample of 24 learners. The research design used was quasi-experimental pretest posttest control group. Mathematics Knowledge Check (MKC) was used to collect data and the data collected were analyzed using mean, standard deviation, mean difference and analysis of covariance (ANCOVA). The hypotheses were tested at 0.05 level of significance. The study found out that achievement in Mathematics improves as a result of exposing learners with hearing impairment to gamification and experiential methods of instruction. Besides, the study observed that the two interventions were of benefit to male and female learners with hearing impairment. The employment of gamification and experiential instructional strategy was recommended for mathematics lessons of learners with hearing impairment.

Keywords: Achievement in Mathematics; Experiential Learning; Gamification; Learners with Hearing Impairment
THE INFLUENCE OF PLANNED BEHAVIOUR THEORY AND KNOWLEDGE TOWARDS THE WAQIF INTENTION IN CONTRIBUTING WAQF
Authors: Alifiandy Mochammad Maulana , Sukmana Raditya 
Published: December 2020

Waqf performance, as part of Islamic social finance is determined by, among others, willingness of society to donate their assets into waqf. Ability to understand determinants of the willingness may contribute to more optimum waqf assets accumulation and management. This study aims to investigate the effect of attitudes, subjective norms, perceived behavioral control, and knowledge in influencing the willingness of waqif to donate through the Airlangga University Social Fund Management Center (PUSPAS). This research is a quantitative study using multiple regression analysis. Data for this study is obtained from 98 respondents. The study results imply that there was no significant simultaneous influence in the variables of attitudes, subjective norms, behavioral control, and knowledge of waqif willingness to represent in PUSPAS. The attitude and knowledge variables are variables that have a significant influence partially. In contrast, the subjective norm variables and behavioral control have a partially insignificant impact on the intention of waqf to represent.
Deductive systems with unified multiple-conclusion rules
Authors: Citkin Alex 
Published: December 2020

Our goal is to develop a syntactical apparatus for propositional logics in which the accepted and rejected propositions have the same status and are being treated in the same way. The suggested approach is based on the ideas of Ƚukasiewicz used for the classical logic and in addition, it includes the use of multiple conclusion rules. A special attention is paid to the logics in which each proposition is either accepted or rejected.
Gender differences in self-harm and drinking behaviors among high school students in Beijing, China
Authors: Li Chai-Quan , ZHANG Jing-Shu , MA Shang , Ruo-Ran LV , DUAN Jia-Li , LUO Dong-Mei , YAN Xiao-Jin , MA Ning , SONG Yi 
Published: December 2020

Abstract
Background

Self-harm and drinking were both serious problems in adolescents and many studies presented evidence of their association. However, gender differences in this association was seldom deeply discussed. Our study was aimed to evaluate the prevalence of self-harm and explore its association with drinking behaviors by gender and investigate the extent to which the gender differences exist in the association between self-harm and drinking.

Methods

A total of 32362 students in grades 7 to 12 were anonymously surveyed and included in our study using two-stage, stratified probability proportion sampling in Beijing, China. Self-harm, drinking behaviors and other basic information were obtained from anonymous questionnaire. Demographic variables, self-harm as well as drinking behaviors were analyzed with Chi-square test and Gamma test between genders and the gender differences in this association was analyzed by log-binomial regression.

Results

The total prevalence of self-harm was 13.7% with no significant gender difference (=0.352, P=0.553). The prevalence of self-harm decreased with age in girls (G=-0.163, P<0.001). Self-harm was associated with drinking behaviors in both boys and girls. The Log-binomial regression demonstrated that girls in 16-19 years were at lower risk of self-harm than girls in 12-15 years while this association was weaker in boys (1.493 vs 1.128). The higher OR for self-harm was found among girls with early drinking experiences compared with boys (2.565 vs 1.863). Girls who ever drunk (2.211 vs 1.636), were currently drinking (3.400 vs 2.122) and binged drinking (6.357 vs 3.924) were of greater risk for self-harm than boys.

Conclusion

Self-harm has significant positive association with drinking among high school students and girls with drinking behaviors were at higher risk of suffering self-harm. Identifying adolescents’ drinking behaviors is of vital importance to self-harm prevention and special attention should be focused on younger girls.