bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Artificial Urine Protocol to Better Imitate Human Urine
Authors: Sarigul Neslihan , Korkmaz Filiz , Kurultak İlhan 
Published: December 2019

AbstractArtificial urine has many advantages over human urine for research and educational purposes. By closely mimicking healthy individuals’ urine, it may also be important in discovering novel biomarkers. However, up until now, there has not been any specific protocol to prove the similarity in terms of the chemical composition at the molecular level. In this study, a new artificial urine protocol is established to mimics the urine of healthy individuals. The multi-purpose artificial urine (MP-AU) presented here is compared with two other protocols most cited in literature. Furthermore, these three protocols are also compared with samples from 28 healthy young individuals. To do so, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) is used, according to which MP-AU shows a significantly close similarity with human urine. In formulating MP-AU, the infrared spectra of nine compounds is provided, making possible the band assignment of some absorption bands to certain compounds. Given its properties, the MP-AU protocol introduced here is both economical and practical, making it useful when designing comparative-controlled experiments.
Management of soil pH promotes nitrous oxide reduction and thus mitigates soil emissions of this greenhouse gas
Authors: Hénault Catherine , Bourennane Hocine , Ayzac Adeline , Ratié Céline , Saby Nicolas P. A. , Cohan Jean-Pierre , Eglin Thomas , Gall Cécile Le 
Published: December 2019

AbstractWhile concerns about human-induced effects on the Earth’s climate have mainly concentrated on carbon dioxide (CO2) and methane (CH4), reducing anthropogenic nitrous oxide (N2O) flux, mainly of agricultural origin, also represents an opportunity for substantial mitigation. To develop a solution that induces neither the transfer of nitrogen pollution nor decreases agricultural production, we specifically investigated the last step of the denitrification pathway, the N2O reduction path, in soils. We first observed that this path is mainly driven by soil pH and is progressively inhibited when pH is lower than 6.8. During field experiments, we observed that liming acidic soils to neutrality made N2O reduction more efficient and decreased soil N2O emissions. As we estimated acidic fertilized soils to represent 37% [27–50%] of French soils, we calculated that liming could potentially decrease France’s total N2O emissions by 15.7% [8.3–21.2%]. Nevertheless, due to the different possible other impacts of liming, we currently recommend that the deployment of this solution to mitigate N2O emission should be based on local studies that take into account agronomic, environmental and economic aspects.
Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer
Authors: Hagihara Takeshi , Kondo Jumpei , Endo Hiroko , Ohue Masayuki , Sakai Yoshiharu , Inoue Masahiro 
Published: December 2019

AbstractCancer cells are exposed to various stresses in vivo, including hydrodynamic stress (HDS). HDS on cancer cells in the blood stream can influence the metastatic potential. Recent studies revealed that circulating tumor cell clusters are more responsible for metastasis than circulating single cells. Nevertheless, most studies on HDS are based on single cells prepared from established cancer cell lines. Here, we used cancer tissue-originated spheroids (CTOS) as a patient-derived, 3D organoid model to investigate the effect of HDS on cancer cell clusters. We found that HDS induced the growth of cancer cell clusters in a population of colorectal CTOSs. Microarray analyses revealed that the multifunctional protein, Annexin 1 (ANXA1), was upregulated upon HDS exposure. Chemically-induced membrane damage also triggered the expression of ANXA1. A knockdown of ANXA1 revealed that ANXA1 regulated HDS-stimulated growth in colorectal CTOSs. Mechanistically, activating the PI3K/AKT pathway downstream of ANXA1 contributed to the phenotype. These findings demonstrate that HDS induces the growth of cancer cell clusters via ANXA1/PI3K/AKT axis, which helps to elucidate the pro-metastatic feature of circulating cancer cell clusters.
Enriched Pyridinic Nitrogen Atoms at Nanoholes of Carbon Nanohorns for Efficient Oxygen Reduction
Authors: Wee Jae-Hyung , Kim Chang Hyo , Lee Hun-Su , Choi Go Bong , Kim Doo-Won , Yang Cheol-Min , Kim Yoong Ahm 
Published: December 2019

AbstractNitrogen (N)-doped nanostructured carbons have been actively examined as promising alternatives for precious-metal catalysts in various electrochemical energy generation systems. Herein, an effective approach for synthesizing N-doped single-walled carbon nanohorns (SWNHs) with highly electrocatalytic active sites via controlled oxidation followed by N2 plasma is presented. Nanosized holes were created on the conical tips and sidewalls of SWNHs under mild oxidation, and subsequently, the edges of the holes were easily decorated with N atoms. The N atoms were present preferentially in a pyridinic configuration along the edges of the nanosized holes without significant structural change of the SWNHs. The enriched edges decorated with the pyridinic-N atoms at the atomic scale increased the number of active sites for the oxygen reduction reaction, and the inherent spherical three-dimensional feature of the SWNHs provided good electrical conductivity and excellent mass transport. We demonstrated an effective method for promoting the electrocatalytic active sites within N-doped SWNHs by combining defect engineering with the preferential formation of N atoms having a specific configuration.
Utility of Centrifugation-Controlled Convective (C3) Flow for Rapid On-chip ELISA
Authors: Espulgar Wilfred , Tadokoro Tatsuro , Tamiya Eiichi , Saito Masato 
Published: December 2019

AbstractMiniaturizing the enzyme-linked immunosorbent assay (ELISA) protocols in microfluidics is sought after by researchers for a rapid, high throughput screening, on-site diagnosis, and ease in operation for detection and quantification of biomarkers. Herein, we report the use of the centrifugation-controlled convective (C3) flow as an alternative method in fluid flow control in a ring-structured channel for enhanced on-chip ELISA. A system that consists of a rotating heater stage and a microfluidic disk chip has been developed and demonstrated to detect IgA. The ring-structured channel was partially filled with microbeads (250 µm in diameter) carrying the capture antibodies and the analyte solution was driven by thermal convection flow (50 µL/min) to promote the reaction. The remaining part of the circular channel without microbeads served as the observation area to measure the absorbance value of the labeled protein. Currently, the system is capable of conducting four reactions in parallel and can be performed within 30 min at 300 G. A detection limit of 6.16 ng/mL using 24 µL of target sample (IgA) was observed. By simply changing the capture antibodies, the system is expected to be versatile for other immunoassays.
The multi-thermal chromosphere
Authors: da Silva Santos J. M. , de la Cruz Rodríguez J. , Leenaarts J. , Chintzoglou G. , De Pontieu B. , Wedemeyer S. , Szydlarski M. 
Published: December 2019

Context. Numerical simulations of the solar chromosphere predict a diverse thermal structure with both hot and cool regions. Observations of plage regions in particular typically feature broader and brighter chromospheric lines, which suggests that they are formed in hotter and denser conditions than in the quiet Sun, but also implies a nonthermal component whose source is unclear.
Aims. We revisit the problem of the stratification of temperature and microturbulence in plage and the quiet Sun, now adding millimeter (mm) continuum observations provided by the Atacama Large Millimiter Array (ALMA) to inversions of near-ultraviolet Interface Region Imaging Spectrograph (IRIS) spectra as a powerful new diagnostic to disentangle the two parameters. We fit cool chromospheric holes and track the fast evolution of compact mm brightenings in the plage region.
Methods. We use the STiC nonlocal thermodynamic equilibrium (NLTE) inversion code to simultaneously fit real ultraviolet and mm spectra in order to infer the thermodynamic parameters of the plasma.
Results. We confirm the anticipated constraining potential of ALMA in NLTE inversions of the solar chromosphere. We find significant differences between the inversion results of IRIS data alone compared to the results of a combination with the mm data: the IRIS+ALMA inversions have increased contrast and temperature range, and tend to favor lower values of microturbulence (∼3−6 km s−1 in plage compared to ∼4−7 km s−1 from IRIS alone) in the chromosphere. The average brightness temperature of the plage region at 1.25 mm is 8500 K, but the ALMA maps also show much cooler (∼3000 K) and hotter (∼11 000 K) evolving features partially seen in other diagnostics. To explain the former, the inversions require the existence of localized low-temperature regions in the chromosphere where molecules such as CO could form. The hot features could sustain such high temperatures due to non-equilibrium hydrogen ionization effects in a shocked chromosphere – a scenario that is supported by low-frequency shock wave patterns found in the Mg II lines probed by IRIS.
Is Magnetic Resonance Imaging Diffusion Restriction of the Optic Disc Head a New Marker for Idiopathic Intracranial Hypertension?
Authors: Nagarajan Elanagan , Digala Lakshmi P. , Sivaraman Manjamalai , Bollu Pradeep C. 
Published: December 2019

Abstract

Background Idiopathic intracranial hypertension (IIH) is a headache syndrome due to raised intracranial pressure of unknown etiology. Before making the diagnosis of IIH, secondary causes of raised intracranial pressure must be ruled out. The radiological features associated with this condition have variable sensitivity and specificity. In this case series, we aim to describe a potential new radiological marker of IIH, that is, diffusion restriction, in the optic disc head and propose that this can be a specific finding in the appropriate clinical picture.

Importance IIH causes vision loss and disabling daily headaches. The diagnosis of this condition is based on history and physical examination findings. Magnetic resonance imaging (MRI) is used to exclude other causes, but specific radiological markers for the diagnosis of IIH are lacking.

Observations Five patients presented with the main complaint of headache, which was associated with blurry vision. All of our patients had a formal neuro-ophthalmological evaluation that confirmed the presence of optic disc edema in both eyes. They also underwent an MRI of the brain that showed diffusion restriction in the optic nerve head in either eye or both eyes. Patients underwent lumbar puncture in the lateral decubitus position, which revealed cerebrospinal fluid opening pressures > 25 cm H2O. They all responded well to standard treatments, with the resolution of symptoms in their follow-up appointments.

Conclusion and Relevance The MRI diffusion restriction in the optic nerve head may be a reliable noninvasive marker for the diagnosis of IIH in the appropriate clinical picture.
Single-electron current gain in a quantum dot with three leads
Authors: Welker Armin C , Weis Jürgen 
Published: December 2019

Abstract
The conductance through a quantum dot (QD) between a source and a drain electrode is usually controlled electrostatically by a nearby gate electrode. A periodic modulation of the conductance versus gate voltage is observed, swapping between Coulomb blockade and single-electron tunneling. By controlling the Fermi level of a third (‘base’) lead attached to the QD, we were able to switch a single-electron current from source to drain, exceeding the single-electron current to or from the base lead. A simple model is presented revealing the role of ground- and excited states within the QD for this dynamic operation of a single-electron transistor.
Noise-induced resistive switching in a memristor based on ZrO2(Y)/Ta2O5 stack
Authors: Filatov D O , Vrzheshch D V , Tabakov O V , Novikov A S , Belov A I , Antonov I N , Sharkov V V , Koryazhkina M N , Mikhaylov A N , Gorshkov O N , Dubkov A A , Carollo A , Spagnolo B 
Published: December 2019

Abstract
Resistive switching (RS) is studied in a memristor based on a ZrO2(Y)/Ta2O5 stack under a white Gaussian noise voltage signal. We have found that the memristor switches between the low resistance state and the high resistance state in a random telegraphic signal (RTS) mode. The effective potential profile of the memristor shows from two to three local minima and depends on the input noise parameters and the memristor operation. These observations indicate the multiplicative character of the noise on the dynamical behavior of the memristor, that is the noise perceived by the memristor depends on the state of the system and its electrical properties are influenced by the noise signal. The detected effects manifest the fundamental intrinsic properties of the memristor as a multistable nonlinear system.
The role of Egyptian State Awards in changing researchers’ performance in the science and technology sector
Authors: Ibrahim Bahaa 
Published: December 2019

AbstractEgyptians generally pay attention to the State Awards as the most prestigious awards that Egyptian researchers can receive, including the Nile Award, the State Appreciation Award, the State Award of Excellence, and the State Encouragement Award. The current study is an attempt to investigate the role of national awards in the scientific research system, in order to identify the characteristics of Egyptian State Award laureates in science and technology during 2012–5, to determine their international literature, and to explore the implications of receiving a national award using bibliometric indicators. Scopus database was used to extract data, and the statistical software package SPSS was used to analyze. The study sample was 212 laureates, in addition to the control group of 184 researchers who closely matches the academic profiles of the laureates. The performance of the laureates and the control group was compared before and after the award by using four bibliometric indicators and the Wilcoxon matched-pairs signed-ranks test. The laureates produced 13,598 publications from 1958 to 2018. Most of the laureates’ literature (94.35%) were published with coauthors. The Egyptian State Award laureates often collaborate with their Saudi Arabian and American colleagues, more than others. The average values of publications, citations, and citations per publication have increased after receipt of the award, unlike the h-index. Results indicated that receiving the State Award has a negative impact on the laureates’ performance.
Bariatric surgery and type 2 diabetes
Authors: Stewart Jennifer , Allen Sarah , Weidman-Evans Emily 
Published: December 2019

ABSTRACT
Type 2 diabetes is primarily managed with lifestyle modifications, self-monitoring of blood glucose, and medication. The goal is to maintain A1C less than 7% in most patients and prevent damage to other organs such as the kidneys and heart. Patients who are obese and cannot achieve normal blood glucose levels despite diet, exercise, and multiple medications may be considered for bariatric surgery. The Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy have been shown to improve A1C, reduce weight, and reduce the number of medications patients need for diabetes management. Comorbidities such as hyperlipidemia and hypertension also may improve. This article describes types of bariatric surgery, proper selection of surgical candidates, patient education, and the postoperative patient management necessary for long-term success in improving blood glucose control.
Helping survivors of sexual assault
Authors: Thompson Katherine M. 
Published: December 2019

ABSTRACT
Sexual assault is a widespread problem in US communities, affecting about one in every three women and one in every eight men. These assaults reverberate through the lives of survivors and their loved ones, often for decades or even a lifetime. Healthcare providers must be empowered and equipped to contribute to the medical and mental health of survivors. This article provides a framework for that knowledge and empowerment.
Supplemental screening in the dense breast: does molecular breast imaging have a role?
Authors: Rhodes Deborah J. 
Published: December 2019

Abstract
With the passage of a 2019 US federal law directing FDA to ensure that mammography facilities provide a summary to patients categorizing their breast density and explaining how it can influence mammography accuracy, providers will increasingly be called on to discuss the options for supplemental screening. Numerous studies have elucidated the extent of masking that occurs with mammography screening in dense breasts when mammography is compared with other supplemental screening modalities. Despite this evidence, there is currently no consensus among experts or imaging societies as to whether or with what supplemental screening should be performed, leaving providers to counsel patients regarding the balance of benefits and harms.
The Impact of Device Innovation on Clinical Outcomes in Expander-based Breast Reconstruction
Authors: Momeni Arash , Li Alexander Y. , Tsai Jacqueline , Wan Derrick , Karin Mardi R. , Wapnir Irene L. 
Published: December 2019

Background:
Staged expander-based breast reconstruction represents the most common reconstructive modality in the United States. The introduction of a novel tissue expander with an integrated drain (Sientra AlloX2) holds promise to further improve clinical outcomes.

Methods:
Patients who underwent immediate expander-based pre-pectoral breast reconstruction were identified. Two cohorts were created, that is, patients who underwent placement of a conventional tissue expander [133MX (Allergan)] (Group 1) versus AlloX2 (Sientra) (Group 2). The study endpoint was successful completion of expansion with the objective being to investigate differences in outcome following expander placement.

Results:
Fifty-eight patients underwent 99 breast reconstructions [Group 1: N = 24 (40 breasts) versus Group 2: N = 34 (59 breast)]. No differences were noted for age (P = 0.586), BMI (P = 0.109), history of radiation (P = 0.377), adjuvant radiotherapy (P = 1.00), and overall complication rate (P = 0.141). A significantly longer time to drain removal was noted in Group 1 (P < 0.001). All patients with postoperative infection in Group 1 required surgical treatment versus successful washout of the peri-prosthetic space via the AlloX2 drain port in 3 of 5 patients in Group 2 (P = 0.196). Furthermore, both cases of seroma in Group 1 required image-guided drainage versus in-office drainage via the AlloX2 drain port in 1 patient in Group 2 (P =0.333).

Conclusion:
The unique feature of the AlloX2 provides surgeons easy access to the peri-prosthetic space without altering any of the other characteristics of a tissue expander. This resulted in a reduced time to drain removal and facilitated management of postoperative seroma and infection.
A Comprehensive Review of Medicinal Leeches in Plastic and Reconstructive Surgery
Authors: Hackenberger Paige N. , Janis Jeffrey E. 
Published: December 2019

Summary:
Medicinal leeches are a US Food and Drug Administration-approved treatment for venous congestion in graft tissue to promote healing and can serve as a nonsurgical option for plastic surgery patients with concern for tissue compromise. Although there is a wealth of documentation on medicinal leech therapy, the surgical space currently lacks an updated summary of proper indications, use, and risks as they pertain to plastic surgical patients. The purpose of this article is to provide a platform for understanding the recent literature as it relates to reconstruction to improve understanding of indications and necessary considerations in using hirudotherapy. Topics examined include basics of hirudotherapy, indications in plastic surgery, implementation (leech application, number and duration of therapy, and removal), risks (infection and bleeding), and alternative treatments. The evidence provided will aid in physician understanding and implementation, patient counseling, and the informed consent process.
Rehab MATRIX: Content Validity of a Nursing-Led Patient Assignment Algorithm
Authors: Ifejika Nneka L. , Okpala Munachi N. , Moser Hope A. , Watkins Jeffrey N. , Noser Elizabeth A. 
Published: December 2019

ABSTRACT

Purpose: The provision of conscientious nursing care is at the forefront of health quality. Unfortunately, a lack of standardization in the assignment of patients to nurses can lead to care inequities. Rehab MATRIX is a nursing-led tool that equitably assigns patients using select acuity variables. Design and Methods: In this initial study, we asked focus groups of 19 registered nurses and 8 patient care assistants to identify medical interventions that increase the effort of nursing care at a 24-bed inpatient rehabilitation facility (IRF). This IRF is affiliated with a comprehensive heart and vascular institute, a level I trauma center, and a The Joint Commission (TJC) Comprehensive Stroke Center. Findings: Thirteen acuity variables were included in the Rehab MATRIX patient assignment grid. High-acuity patients with greater than 6 variables were color-coded “red,” medium-acuity patients with 3 to 5 variables were color-coded “yellow,” and low-acuity patients with less than 3 variables were color-coded “green.” Each registered nurse and patient care assistant were assigned an equitable number of red-, yellow-, and green-coded patients per shift. New admissions were Rehab MATRIX color-coded during nursing report and assigned objectively. Conclusions: Nursing staff at a wide-ranging IRF created Rehab MATRIX, an equitable patient assignment tool, representative of nursing effort needed to provide quality care. Clinical Relevance: Nursing-led patient assignment tools increase autonomy and provide the opportunity for all nursing staff to influence healthcare practice. These factors may lead to increased nursing satisfaction and decreased burnout.
The Cue-Response Theory and Nursing Care of the Patient With Acquired Brain Injury
Authors: Olson DaiWai M. , Ortega-Pérez Stefany 
Published: December 2019

ABSTRACT
The cue-response theory is herewith proposed to replace the coma cue-response conceptual framework as a nursing theory for care of patients with acquired brain injury (ABI). After ABI, nurses assess patients and develop an understanding of their condition by interpreting meaning from physiologic and observational or behavioral cues. These interpretations form the basis for optimizing the timing of discrete nursing interventions; the outcome of which influences the trajectory toward recovery or toward secondary brain injury. The cue-response theory applies specifically for nurses’ use to determine which interventions should be used and when those interventions should be carried out. The theory recognizes the knowledge potential and knowledge produced in the context of nursing care of all patients with ABI, not just those with coma, and broadens our understanding of how the timing of nursing interventions directly impacts secondary brain injury and the brain entropy state.