bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Relationships between COVID-19 infection rates and Air Pollution, Geo-Meteorological and Social Parameters in Dhaka, Bangladesh
Authors: Hassan Md. Shareful , Bhuiyan1 Mohammad Amir Hossain , Tanu Saikat Mandal , Tareq Md. Faysal , Bodrud-Doza Md. , Rabbani K. A. 
Published: June 2020

Abstract
Like all infectious diseases, the infection rate of COVID-19 is dependent on many variables. Geographically Weighted Regression (GWR) model and GIS was used to understand the associations between COVID-19 infection rate as a dependent variable and 17 independent variables of air pollution, geo-meteorological and social parameters using a set of temporal data from 2010-2020 (May) in Dhaka, Bangladesh. This study revealed that air pollution parameters like PM2.5 (p<0.02), AOT (p<0.01), CO (p<0.05), water vapor (p<0.01) and O3 (p<0.01) were highly correlated with COVID-19 infection rate while geo-meteorological parameters like DEM (p<0.01), wind pressure (p<0.01), LST (p<0.04), rainfall (p<0.01) and wind speed (p<0.03) were also similarly associated . Social parameters like population density (p<0.01), brickfield density (p<0.02), and poverty level (p<0.01) showed high coefficients as the key independent variables to COVID-19 infection rate. Geographically, significant robust relationships of these factors were found in the middle and southern parts of the city where the reported infection case was also higher. Relevant agencies can utilize these findings to formulate new and smart rules or strategies for reducing infectious diseases like COVID-19 in Dhaka and in similar urban cities around the world.
Infantile Prognosis of Neonates Conceived by Assisted Reproductive Techniques: A prospective Study
Authors: Khoei Ellieh , Afjeh Seyyed Abolfazl , Tajalli Saleheh , Fallahi Minoo 
Published: June 2020

Abstract
Introduction: Outcomes of neonates of infertile couples that are golden babies and care of them is an issue of importance. But it is not yet clear if the prognosis is different between them and neonates from fertile couples. The purpose of this study was to determine the outcome of neonates conceived by assisted reproductive techniques.Methods: In this cohort study, a total of 165 newborn who were conceived by assisted reproductive techniques (ART) and 165 naturally concieved newborns were enrolled. The study was prospective from April 2017 to October 2019. All newborns were examined by neonatologist after birth and their outcome were followed up to two year. The outcomes were compared with neonates from fertile couple using appropriate statistical tests.Results: The preterm neonates (60% vs. 38%) were higher in ART cases (P<0.001). The mean gravid and parity were lower in ART group (P<0.001) and the nulliparity was higher in them. Multiple pregnancies were higher in ART cases (45% vs. 10%; P<0. 001). Cesarean section rate was higher (91% vs 67%) in ART cases (P<0.001). Pre-eclampsia rate was higher in ART cases (16 % vs. 6%; P=0.004). Female sex was higher in ART group (P=0.035). Birth weight was significantly lower in ART group (P=0.002) and the Apgar was also lower (P=0.002; P=0.012). Intrauterine growth restriction was significantly higher (17% vs. 7%) in ART group (P=0.006). Necrotizing enterocolitis and respiratory distress syndrome were more common in ART group (P<0.001). Hospital stay was longer in ART group (P<0.001). Re-admission, and weight less than 5th percentile were more common after two year in ART group (P=0.021).Conclusion: According to the obtained results, pregnancy after ART has more side effects before and after birth and also in infancy; not only because of multigestation but also due to manipulations in ART.
Is hydroxychloroquine with macrolide a good combination in COVID-19 compared to hydroxychloroquine alone from cardiac perspective? A systematic review and meta-analysis
Authors: Khadka Sitaram , Budhathoki Pravash , Shrestha Dhan Bahadur , Rawal Era 
Published: June 2020

Abstract
Background: The global spread of COVID-19 and the lack of definite treatment has caused an alarming crisis in the world. Hydroxychloroquine (HCQ) and azithromycin (AZT) are considered a possible treatment option. We aimed to evaluate the outcome and potential harmful cardiac effects of AZT+HCQ compared to HCQ alone for COVID-19 treatment.Methods: Pubmed, Medline, Google Scholar, Cochrane Library, and clinicaltrials.gov were searched using appropriate keywords and identified six studies using PRISMA guidelines. The quantitative synthesis was performed using fixed and random effects for the pooling of studies. Result: In this systematic review and meta-analysis, the risk of mortality (RR 1.16; 0.92-1.46) and adverse cardiac events (OR 1.06; 0.82-1.37) demonstrated a small increment though of no significance. There are no increased odds of mechanical ventilation (OR 0.84; 0.33-2.15) and significant QTc prolongation (OR 0.84, 0.59-1.21). Neither the critical QTc threshold (OR 1.92, CI 0.81-4.56) nor absolute ΔQTc ≥60ms (OR 1.95, CI 0.55-6.96) is increased to the level of statistical significance among HCQ+AZT arm compared to HCQ alone; but its slightly increased odds need to be considered in clinical practice. Conclusion: The combination of AZT+HCQ leads to small increased odds of mortality and cardiac events compared to HCQ alone. It is of no statistical significance for the critical QTc threshold and absolute ΔQTc ≥60ms, but increased odds with HCQ+AZT arm need to be considered in clinical relevance. Our result does not guide against the use of combination or HCQ alone based on the present level of evidence.
Recovery of moderate COVID-19 disease in a liver transplant recipient on continued immunosuppression
Authors: Mathiasen Victor Dahl , Karlsen Stine , Ott Peter , Jensen-Fangel Søren , Leth Steffen 
Published: June 2020

Abstract
BackgroundThe global outbreak of severe acute respiratory syndrome coronavirus 2 has had an enormous impact on the world. It remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease due to the limited data available.Case presentationWe describe a moderate course of COVID-19 in a patient who underwent a liver transplant two years earlier due to Budd-Chiari syndrome. She presented with malaise, headache, dry cough and fever for four days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection, oxygen therapy was given for a single night and the patient gradually recovered with supportive care only.ConclusionsWith this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 disease and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with a higher mortality.
What to propose to treat post-viral non-conductive smell disorder in COVID-19? - systematic review with meta-analysis
Authors: Costa Klinger Vagner Teixeira da , Carnaúba Aline Tenório Lins , Rocha Katianne Wanderley , Andrade Kelly Cristina Lyra de , Menezes Pedro de L. 
Published: June 2020

Abstract
ObjectiveTo conduct a systematic review with meta-analysis on the treatments for post-viral non-conductive olfactory disorder (NCSD) to be proposed for olfactory disorder in COVID-19.Study designSystematic review and meta-analysis with searches between June 10th and 13th, 2020 in the databases: Medline via PubMed, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus, Google Schoolar and Web of Science and gray literature. Inclusion criteria: (1) clinical trials with NCSD; (2) olfactory assessment before and after the intervention using a validated method; exclusion criteria: (1) NCSD from neurological causes; (2) studies unrelated to NCSD treatment; (3) duplicate publications. The quality of the studies was assessed by two independent researchers according to the Cochrane Collaboration recommendations.ResultsA total of thirteen clinical trials met the criteria: nine on drug treatments and four on olfactory training with four odors. In drug treatments, caroverine, vitamin A, insulin, pentoxifylline, alpha-lipoic acid and sodium citrate were evaluated. The meta-analysis (336 patients) identified, through the random effect analysis, a statistically significant improvement between the TDI score before and after the olfactory training was observed (SMD = 5.18; 95% confidence interval (CI) [4.12, 6.23], p<0.00001).ConclusionSodium citrate and olfactory training are therapeutic approaches to recover olfactory function in post-viral NCSD and can be considered considered for NCSD due to COVID-19; however, further clinical trials are needed to confirm the results evaluated and establish treatment protocols.
CONTRIBUIÇÃO DA FISIOTERAPIA SEGUNDO MÉDICOS E ENFERMEIROS DAS UNIDADES BÁSICAS DE SAÚDE DA FAMÍLIA
Authors: Zarili Thais Fernanda Tortorelli , Dias Maria Dionísia do Amaral 
Published: June 2020

O objetivo do trabalho consiste em identificar os principais obstáculos no processo de trabalho das equipes de Atenção Primária à Saúde (APS) e a contribuição das ações e serviços de Fisioterapia para o cuidado integral dos usuários, segundo a percepção de médicos e enfermeiros da Estratégia de Saúde da Família de Botucatu (SP). Estudo descritivo, com abordagem qualitativa utilizou questionário semiestruturado. As respostas dicotômicas foram analisadas segundo a frequência e as respostas abertas segundo análise temática. Participaram da pesquisa 28 profissionais, na maioria do sexo feminino. Os resultados demonstram a sobrecarga de trabalho pelo excesso de demanda e dificuldades com relação ao próprio serviço, à equipe e à gestão municipal, evidenciou que tais profissionais possuem conhecimento quanto à atuação da Fisioterapia e que há diversas demandas que necessitam do apoio matricial do fisioterapeuta ou de encaminhamentos aos serviços especializados de Fisioterapia, assim como compreendem a contribuição para a resolutividade dos casos atendidos no serviço e a melhoria da qualidade de vida do paciente. A inserção do fisioterapeuta corrobora com a clínica ampliada enquanto ferramenta para o cuidado e o fortalecimento das suas ações deve estar em consonância com as necessidades do território e articuladas com a equipe do serviço.
ADHERENCE, ADVERSE DRUG REACTION AND EFFECTIVENESS OF THE HEPATITIS C CHRONIC TREATMENT
Authors: Schwambach Karin , Blatt Carine Raquel 
Published: June 2020

Objective: To assess adherence, adverse drug reaction and Sustained Virological Response (SVR) in the therapy for hepatitis C. This follow-up retrospective observational study was conducted in a specialized center for hepatitis treatment in Southern Brazil. Methods: This research included 257 patients under hepatitis C treatment with all‐oral direct‐acting antivirals in a clinical setting from March to August 2016. The data was obtained from medical records. Adherence was measured by medicines refill and Medication Possession Ratio. Results: Of the 253 patients evaluated, 8,7% had some problem with adherence to the treatment. No cases of treatment discontinuation due to adverse drug reaction was observed. However, 1433 adverse drug reactions were identified and classified as mild, with an average of 5,6 per patient. The most frequent reactions were headache (55,7%), asthenia (47,3%), altered appetite (41,9%), dry skin (37,2%), and nausea/vomiting (35,9%). The overall SVR rate was 90,9%. Other outcomes were no response to treatment (2,0%), relapsed (2,0%), dead (0,4%), dropout (0,4%) and lost to follow-up (4,3%). In the multivariate analysis, hepatitis C virus and human immunodeficiency virus co-infection and longer treatment time were associated with higher SVR (p = 0,028 and p = 0,020, respectively). Conclusion: The treatments evaluated have high response rate and were well tolerated by the patients. Adherence to treatment proved to be adequate and contributed to the results. The care offered in a specialized center provides the appropriate management of the patients’ needs, contributing thus to a successful therapy.
THE WAY THE LOCAL GOVERNMENT WORKS TO FIGHT AGAINST CORRUPTION IN KUPANG CITY IN THE PERSPECTIVES OF GENERATIONS X AND Y
Authors: Thoomaszen Friandry Windisany , Tameon Sance Mariana 
Published: June 2020

Generations Y and Z are the next generations of the Indonesian nation, including in the process of preventing and eradicating corruption. These two generations tend to have the same weaknesses, that is, the tendency to be apathetic towards the government and politics. This apathy can be an obstacle to eradicating corruption cases in the future when these generations occupy strategic positions. The aim of the study is to find out the views of generations Y and Z on the way the local government works to eradicate corruption cases in Kupang City. The researchers use a quantitative approach, with descriptive survey research methods. The research subjects are 78 Christians from the generation Y and Z who live in Kupang City. The sampling technique used is stratified random sampling which is spread using the google forms (online) format. The results of the study show that generation Y and Z are sensitive to cases of corruption that are taking place in their domicile, Kupang City. Out of 78 subjects of generation Y and Z, the majority or 42 subjects answer that the level of corruption in Kupang City is at a severe level. Generation Z also looks more familiar with Nine anti-corruption values than generation Y. There are various solutions offered by generations Y and Z for regional leaders to overcome corruption in Kupang City. However, the solution to the campaign is still considered to be less effective in dealing with corruption for generation Y and Z. It is recommended that local governments see and use the opinions of generation Y and Z to improve themselves and the anti-corruption system and involve generation Y and Z to prevent, fight, and eradicate corruption cases actively both in real actions and in cyberspace (social media). Anti-corruption behavior conveyed to generations Y and Z must be more attractive, modern, and in accordance with the characteristics of these two generations who have a dependency on cyberspace.
Analisis Textbooks-for-High-School-Student- Studying-the Sciences-Chemistry materi Pokok Hidrokarbon dalam Perspektif Kurikulum 2013
Authors: Rizqiana Fika Atina , Siddiq Mahfudz , Rahmawati Atik 
Published: June 2020

<p><em>Penelitian ini bertujuan untuk mengetahui sajian materi hidrokarbon (kelengkapan materi, akurasi, pemecahan masalah, komunikasi, koneksi, dan penyampaian) pada bahan ajar Textbooks For High School Students Studying The Sciences Chemistry yang diterbitkan oleh FHSST Author Afrika Selatan serta relevansinya dengan kurikulum 2013 untuk SMA Kelas X. Penelitian dilakukan dengan menggunakan metode analisis dokumen (documentary analysis) atau analisis isi (content analysis). Teknik pengumpulan data yang digunakan yaitu dokumentasi dan wawancara. Hasil penelitian menunjukkan bahwa aspek kelengkapan materi 62,5% (cukup); akurasi 58,3% (kurang); pemecahan masalah sebesar 75% (baik); komunikasi 62,5% (cukup); koneksi (keterkaitan) 50% (kurang); penyampaian (represent) 62,5% (cukup). Adapun relevansi materi hidrokarbon pada Textbooks For High School Students Studying The Sciences Chemistry dengan kurikulum 2013 adalah sebesar 31,2 % (sangat kurang). Berdasarkan hasil penelitian, dapat diketahui bahwa materi pokok hidrokarbon pada Textbooks For High School Students Studying The Sciences Chemistry terbitan FHSST Authors dari Afrika Selatan tidak memenuhi dari segi isi materi, relevansi dengan kurikulum, dan pembahasannya belum lengkap untuk pembelajaran di SMA kelas X. </em></p>
Pengembangan Modul Kimia Socio-Scientific Issues (SSI) Materi Reaksi Reduksi Oksidasi
Authors: Sofiana Sofiana , Wibowo Teguh 
Published: June 2020

<p>Penelitian pengembangan ini dilatarbelakangi oleh kesulitan belajar pada materi reaksi reduksi oksidasi yang dialami peserta didik akibat terbatasnya jumlah bahan ajar yang dapat digunakan secara mandiri, kurangnya variasi bahan ajar yang digunakan guru, dan rendahnya motivasi belajar peserta didik karena menganggap mata pelajaran kimia adalah mata pelajaran yang sulit, dan tidak berkaitan langsung dengan kehidupan, khususnya materi reaksi reduksi oksidasi. Hal ini ditunjukkan oleh adanya 58,9% peserta didik yang menyatakan materi reaksi reduksi oksidasi adalah materi yang sulit. Bahan ajar yang memberikan kesempatan bagi peserta didik untuk belajar menurut kecepatan masing-masing adalah modul. Tujuan penelitian ini adalah untuk menghasilkan modul yang memuat pembelajaran kontekstual dengan pendekatan socio-scientific issues (SSI). Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan ADDIE (Analyze, Design, Develop, Implement, Evaluate). Subjek penelitian pengembangan ini adalah 9 peserta didik kelas X MIA 2 MA Al-Irsyad Gajah. Hasil penilaian kualitas modul yang dilakukan oleh validator ahli materi diperoleh sebesar 84,60% dengan kategori sangat valid. Penilaian validator ahli media sebesar 91,00% dengan kategori sangat valid, dan respon peserta didik sebesar 80,69%. Sedangkan rata-rata skor untuk uji keterbacaan modul sebesar 68,88% dengan kategori keterbacaan tinggi. Hasil tersebut menunjukkan bahwa modul yang dikembangkan layak digunakan dan diimplementasikan pada kelas besar.</p>
PENTINGNYA PERAN TUTOR DALAM PEMBELAJARAN DI DUMPIT
Authors: Purba Friska Juliana 
Published: June 2020

<p class="E-JournalAbstractBodyIndo">Melihat kondisi anak-anak di wilayah Pos Dumpit dimana ada anak yang tidak dapat bersekolah, dan ditemukan juga kondisi anak-anak yang seharusnya sudah berada di level yang tinggi akan tetapi secara kemampuan masih berada di level yang rendah. Hal ini disebabkan karena keterbatasan perekonomian keluarga dimana mata pencaharian keluarga itu sebagian besar buruh serabutan, kuli cuci piring, dan pemulung. Hal inilah yang menyebabkan kondisi pendidikan mereka kurang layak dibandingkan dengan anak-anak yang memperoleh pendidikan di tempat lain. Untuk itu bimbingan belajar Pos Dumpit hadir dan bertujuan untuk (1) Meningkatkan kemampuan membaca, menulis, dan menghitung pada anak-anak dengan cara memberikan pembelajaran yang menarik dan menyenangkan pada anak TK dan SD, (2) Membantu anak-anak dalam memahami pelajaran yang sulit di sekolah, (3) Membantu anak-anak dalam menanamkan sikap berjuang melalui belajar yang giat, (4) Membantu anak-anak dalam meningkatkan kemampuan berpikir dan perubahan tingkah laku pada anak-anak menuju ke arah yang lebih baik. Bimbingan belajar ini menghadirkan tutor-tutor yang sudah diperlengkapi secara pedagogy maupun ilmu pengetahuan. Strategi pembelajaran yang dipergunakan tutor bervariasi, disesuaikan dengan kebutuhan dari tutee dan tingkatan. Dengan melihat kebutuhan tutee, maka tutor dapat meningkatkan motivasi dan keinginan belajar mereka. Harapannya bimbingan belajar ini tetap dapat bermanfaat bagi anak-anak, masyarakat, dan menjadi pembelajaran juga untuk tutor.</p><p> </p><p>Kata kunci: Dumpit, bimbingan belajar, tutor</p>
Cancer Pro-oxidant Therapy Through Copper Redox Cycling: Repurposing Disulfiram and Tetrathiomolybdate
Authors: Rieber Manuel 
Published: June 2020

Background:
Copper (Cu) is a transition metal active in Fenton redox cycling from reduced Cu+ and
H2O2, to oxidized Cu2+ and the hydroxyl radical (·OH) highly reactive oxygen species (ROS). At homeostatic Cu
levels, ROS promote cell proliferation, migration, angiogenesis, and wound repair. To limit ROS toxicity, cells
use Cu-dependent chaperone proteins, Cu-binding ceruloplasmin, and Cu-modulated enzymes like superoxide
dismutases (SOD) like SOD1 and SOD3 to scavenge excess superoxide anions which favour Cu+ reduction, and
mitochondrial cytochrome c oxidase, important in aerobic energy production. Because Cu helps drive tumor cell
proliferation by promoting growth factor-independent receptor tyrosine kinase signaling, and Cu-dependent
MEK1 involved in oncogenic BRAF-V600E signaling, further augmenting bioavailable Cu may promote ROS overproduction,
cancer progression and eventually tumor cell death. For these reasons, the following clinically approved
copper chelators are being repurposed as anti-cancer agents: a) ammonium tetrathiomolybdate (TTM)
used to treat Wilson’s disease (copper overload) and Menkes disease (copper deficiency); b) Disulfiram (DSF),
used against alcoholism, since it inhibits Aldehyde Dehydrogenase (ALDH1) enzyme, important in ethanol detoxification,
and a key target against cancer stem cells. Moreover, TTM and DSF are also relevant in cancer clinical
trials, because they increase the uptake of both Cu and Platinum (Pt)-containing anti-cancer drugs, since Pt
and Cu share the same CTR1 copper transporter.

Purpose:
The majority of reports on Cu chelators dealt separately with either TTM, DSF or others. Here, we
compare in parallel, the anti-cancer efficacy of low doses of TTM and DSF, asking whether they can be synergistic
or antagonistic. The relevance of their unequal ROS inducing abilities and their different behavior as ionophores
is also addressed.

Significance:
The potential of Cu chelators as repurposed anti-cancer drugs, should be greater in patients with
higher endogenous Cu levels. Since platinum and Cu share uptake receptors, the synergism by drugs containing
these metals should not be under-estimated. The potential of disulfiram or its metabolically active Cu-containing
form, to inhibit ALDH1-positive tumor cells is therapeutically very important.
Chemical Composition and Antibacterial Activities of Sumac Fruit (Rhus coriaria) Essential Oil on Dental Caries Pathogens
Authors: Moghadam Parisa , Dadelahi Shahram , Hajizadeh Yasamin S. , Matin Milad G. , Amini Milad , Hajazimian Saba 
Published: June 2020

Introduction:
Dental caries is an infectious disease, and various microorganisms are involved in its progression. The common antibacterial agents against oral pathogens have many side effects and their excessive use cause drug resistance. Therefore, the identification of natural compounds and medicinal plants with antibacterial activity has been considered by the researchers. The Sumac (Rhus coriaria) is one of the native plants of Iran, which used as a food flavoring.

Aims & Objectives:
The aim of this study was to evaluate the antimicrobial activity of Sumac essential oil on oral pathogens, including Streptococcus mutans, Lactobacillus rhamnosus, and Actinomyces viscosus.

Materials & Methods:
In this study, the Sumac essential oil was prepared and its antibacterial activity was evaluated by disk diffusion, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) methods on established terminology strains of S. mutans, L. rhamnosus, and A. viscosus.

Results:
The obtained results showed that the Sumac essential oil has high inhibitory effects against S. mutans, followed by L. rhamnosus and A. viscosus. The predominant compound in the Sumac essential oil was related to Beta-caryophyllene.

Conclusion:
In conclusion, Sumac essential oil has an appropriate antibacterial activity and can be used in the pharmaceutical industry to produce antibacterial agents and mouthwash, against oral infectious diseases and dental caries.