bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis of sevoflurane exposure effects at the different brain regions
Authors: Yamamoto Hiroto , Uchida Yutaro , Chiba Tomoki , Kurimoto Ryota , Matsushima Takahide , Inotsume Maiko , Ishikawa Chihiro , Li Haiyan , Shiga Takashi , Muratani Masafumi , Uchida Tokujiro , Asahara Hiroshi 
Published: December 2020

Backgrounds
Sevoflurane is a most frequently used volatile anesthetics, but its molecular mechanisms of action remain unclear. We hypothesized that specific genes play regulatory roles in brain exposed to sevoflurane. Thus, we aimed to evaluate the effects of sevoflurane inhalation and identify potential regulatory genes by RNA-seq analysis.

Methods
Eight-week old mice were exposed to sevoflurane. RNA from medial prefrontal cortex, striatum, hypothalamus, and hippocampus were analysed using RNA-seq. Differently expressed genes were extracted and their gene ontology terms were analysed using Metascape. These our anesthetized mouse data and the transcriptome array data of the cerebral cortex of sleeping mice were compared. Finally, the activities of transcription factors were evaluated using a weighted parametric gene set analysis (wPGSA). JASPAR was used to confirm the existence of binding motifs in the upstream sequences of the differently expressed genes.

Results
The gene ontology term enrichment analysis result suggests that sevoflurane inhalation upregulated angiogenesis and downregulated neural differentiation in each region of brain. The comparison with the brains of sleeping mice showed that the gene expression changes were specific to anesthetized mice. Focusing on individual genes, sevoflurane induced Klf4 upregulation in all sampled parts of brain. wPGSA supported the function of KLF4 as a transcription factor, and KLF4-binding motifs were present in many regulatory regions of the differentially expressed genes.

Conclusions
Klf4 was upregulated by sevoflurane inhalation in the mouse brain. The roles of KLF4 might be key to elucidating the mechanisms of sevoflurane induced functional modification in the brain.
Coagulation profile of COVID-19 patients admitted to the ICU: An exploratory study
Authors: Corrêa Thiago Domingos , Cordioli Ricardo Luiz , Campos Guerra João Carlos , Caldin da Silva Bruno , dos Reis Rodrigues Roseny , de Souza Guilherme Martins , Midega Thais Dias , Campos Niklas Söderberg , Carneiro Bárbara Vieira , Campos Flávia Nunes Dias , Guimarães Hélio Penna , de Matos Gustavo Faissol Janot , de Aranda Valdir Fernandes , Rolim Ferraz Leonardo José 
Published: December 2020

Background
Coagulation abnormalities in COVID-19 patients have not been addressed in depth.

Objective
To perform a longitudinal evaluation of coagulation profile of patients admitted to the ICU with COVID-19.

Methods
Conventional coagulation tests, rotational thromboelastometry (ROTEM), platelet function, fibrinolysis, antithrombin, protein C and S were measured at days 0, 1, 3, 7 and 14. Based on median total maximum SOFA score, patients were divided in two groups: SOFA ≤ 10 and SOFA > 10.

Results
Thirty patients were studied. Some conventional coagulation tests, as aPTT, PT and INR remained unchanged during the study period, while alterations on others coagulation laboratory tests were detected. Fibrinogen levels were increased in both groups. ROTEM maximum clot firmness increased in both groups from Day 0 to Day 14. Moreover, ROTEM–FIBTEM maximum clot firmness was high in both groups, with a slight decrease from day 0 to day 14 in group SOFA ≤ 10 and a slight increase during the same period in group SOFA > 10. Fibrinolysis was low and decreased over time in all groups, with the most pronounced decrease observed in INTEM maximum lysis in group SOFA > 10. Also, D-dimer plasma levels were higher than normal reference range in both groups and free protein S plasma levels were low in both groups at baseline and increased over time, Finally, patients in group SOFA > 10 had lower plasminogen levels and Protein C ​​than patients with SOFA <10, which may represent less fibrinolysis activity during a state of hypercoagulability.

Conclusion
COVID-19 patients have a pronounced hypercoagulability state, characterized by impaired endogenous anticoagulation and decreased fibrinolysis. The magnitude of coagulation abnormalities seems to correlate with the severity of organ dysfunction. The hypercoagulability state of COVID-19 patients was not only detected by ROTEM but it much more complex, where changes were observed on the fibrinolytic and endogenous anticoagulation system.
Factors associated with divorce from first union among women in Ethiopia: Further analysis of the 2016 Ethiopia demographic and health survey data
Authors: Dagnew Gizachew Worku , Asresie Melash Belachew , Fekadu Gedefaw Abeje , Gelaw Yared Mulu 
Published: December 2020

Background
Globally, divorce is a common phenomenon in couples' marital life. As a result, many divorced couples and their children face several social, economic, and health problems after dissolution. There is little information on the magnitude and determinants of divorce in developing countries including Ethiopia. Therefore, this study aimed to estimate the prevalence of divorce from the first union and its predictors among reproductive-age women in Ethiopia.

Methods
We used the 2016 Ethiopia demographic and health survey data for this analysis. The survey was a community-based cross-sectional study conducted from January 18 to June 27, 2016. The survey employed a two-stage stratified cluster sampling technique. A total of 11,646 ever-married women were included in the analysis. Bivariate and multivariable logistics regression was done to identify the determinants of divorce from the first marriage. A p-value < 0.05 was used to declare statistical significance.

Results
About 25% (95%CI: 23.4% - 26.6%) ever-married women were divorced from their first marital relationship. Women who were married at age < 15 years (AOR = 1.34; 95%CI: 1.07–1.68), urban women (AOR = 1.69; 95%CI: 1.22–2.35), women who did not attend formal education (AOR = 4.36; 95%CI: 3.14–6.05), women who were employed (AOR = 1.51; 95%CI: 1.31–1.73), and being childless (AOR = 1.34; 95%CI: 1.07–1.69) had higher odds of experiencing a divorce. Similarly, women who experienced partner violence, women with no house ownership, and women in the Amhara region had higher odds of divorce from their first marital union. Conversely, women in Oromia, SNNPR, the metropolis, and the pastoral regions had lower odds of divorce from their first marital union.

Conclusion
Divorce from the first marriage is high in Ethiopia. Preventing early marriage and partner violence and promoting girls’ education would reduce the divorce rate in Ethiopia.
Quantitative measurements of aerosols from air-polishing and ultrasonic devices: (How) can we protect ourselves?
Authors: Kaufmann Manuela , Solderer Alex , Gubler Andrea , Wegehaupt Florian J. , Attin Thomas , Schmidlin Patrick R. 
Published: December 2020

Aim
To assess the distribution and deposition of aerosols during simulated periodontal therapy.

Methods
A manikin with simulated fluorescein salivation was treated by four experienced dentists applying two different periodontal treatment options, i.e. air-polishing with an airflow device or ultrasonic scaling in the upper and lower anterior front for 5 minutes, respectively. Aerosol deposition was quantitatively measured on 21 pre-defined locations with varying distances to the manikins mouth in triplicates using absorbent filter papers.

Results
The selected periodontal interventions resulted in different contamination levels around the patient’s mouth. The highest contamination could be measured on probes on the patient’s chest and forehead but also on the practitioner’s glove. With increasing distance to the working site contamination of the probes decreased with both devices. Air-polishing led to greater contamination than ultrasonic.

Conclusion
Both devices showed contamination of the nearby structures, less contamination was detected when using the ultrasonic. Affirming the value of wearing protective equipment we support the need for universal barrier precautions and effective routine infection control in dental practice.
Apories et autisme cognitif synchroniques d’un systême multiscalaire, quasi-conscient d’être inconscient
Authors: Andriamisa-Ramihone Amédée Marie 
Published: December 2020

Catalyseur, la pandémie Covid19 a exacerbé les absurdités et les incohérences (burn out sociétal) des politiques publiques d’un système complexe, le monde des finitudes. Ruptures écologique, technologique, économique, organisationnelle et enfin paradigmatique, puis inégalités sociales maintenant déconfinées, et angle mort (ottoscharmerien) de l’échec collectif s’invitent et bouleversent cette ataraxie de l’homme du xxe siècle. Pris dans une fièvre obsidionale, ne s’est-il pas préparé à une castramétation dans les règles de l’art, subissant une poliorcétique par la pandémie et entraînant un contexte de faillite généralisée des institutions, bref une crise systémique ?
Aujourd’hui, industrialisation, financiarisation, massification, marchandisation disloquent le potentiel de la pensée noétique de l’homme, et partant sa Con-Science, présentant ainsi un présent hoplitique. Comme les Romains de la fin de la République, "nous ne pouvons plus supporter ni nos vices ni leurs remèdes" disait Tite Live. Le système s’empêtre dans ses contradictions …aporétiques et semble embourbé dans sa logique délétère, le menant au mieux dans un statu quo et au pire vers une régression bloquée dans ses connaissances acquises ! Une troisième voie est-elle possible et envisageable ? Car tout compte fait, c’est la conscience humaine qui est confinée dans un présent, souhaité frugal et noétique mais sans arriver à s’en dépêtrer cependant !
"S’enrichir des expériences passées, prendre en compte les situations présentes tout en étant attentif à un avenir qui émerge" est l’apophtegme idoine quand il va falloir repenser le monde. Certes, "la planète vit, titube, roule, hoquète, pète, au jour le jour" selon Edgar Morin en pensant sortir du xxe siècle, aussi ne faudra-t-il pas conjuguer et synchroniser la trilogie "Passé-Présent-Futur" avec le trièdre aristotélicien de l’homme "Pneuma-Soma-Psukhe" ?
Le futur qui émerge se prépare et s’anticipe, ce qui signifie qu’il ne faut pas seulement tourner la page, mais changer carrément de livre ! Changer de registre, de paradigme, voire changer d’ère requiert du temps pour que les plis prennent (expression menant au concept cum-plexus). La complexité systémique ne se résout pas aisément quand il faut "prendre le passé pour faire le présent et anticiper le futur", pour déconstruire et décoloniser l’imaginaire, puis décloisonner les connaissances, à travers une judicieuse Knowledge Management…. La prospective qui n’est pas une discipline ou techniques visant à "prédire" l'avenir (l'avenir est imprévisible et sera ce que l'on fera : "On ne décide pas de l’avenir, il se décide", disait Hannah Arendt !) mais à en étudier les processus, les possibles et les souhaitables, se profile à l’horizon en embuscade, pour servir d’outil permettant de re-penser le monde après cette pandémie !
Les causes de décès aux grands âges en France, évolution récente
Authors: Meslé France , Vallin Jacques 
Published: December 2020

Dans les pays les plus avancés, la mort survient de plus en plus aux grands âges. En France, par exemple, en 2016, 73 % des décès féminins se sont produits après 85 ans, alors que ce n’était le cas que de 41 % en 1975 et même seulement 25 % en 1950. Alors que le sujet paraissait jadis anecdotique, des chercheurs s’interrogent de plus en plus sur ce que peuvent être les causes de décès aux grands âges. Beaucoup, cependant, estiment que la question est relativement vaine car plus l’âge avance, plus les causes sont multiples ce qui rend d’autant plus difficile la détermination d’une cause principale tandis que de leur côté les médecins déclarants posent souvent des diagnostics flous. Il est vrai que le nombre de décès dont la cause est mal définie, voire non déclarée, augmente avec l’âge, mais il nous semble néanmoins que les certificats médicaux de cause de décès portent de plus en plus d’informations exploitables jusqu’à des âges très avancés dans beaucoup de pays, dont la France. Dans le même temps, la précision des âges au décès recueillis par la statistique de l’état civil, longtemps assez défaillante aux grands âges, s’est beaucoup améliorée au cours des dernières décennies.
Nous tentons donc ici de suivre l’évolution de la mortalité française par cause et par âge au-delà de 90 ans, depuis la fin des années 1970, tant pour les hommes que pour les femmes. Non seulement, l’étude confirme que la mortalité diminue à tous les âges, y compris les plus élevés, et quel que soit le sexe. Elle nous permet aussi d’évaluer le poids de chacun des grands groupes de causes (cancers, maladies du cœur, autres maladies de l’appareil circulatoire, maladies infectieuses et respiratoires, diabète, démences et maladies neuro-dégénératives, autres maladies, accidents et sénilité), dans ce recul de la mortalité aux âges élevés et donc dans la montée des espérances de vie à 90 ans, ainsi que le rôle qu’ils jouent dans la différence d’espérance de vie entre les sexes dont l’évolution, même aux grands âges s’est récemment retournée.
Book Review: Hanging Out, Messing Around, and Geeking Out: Kids Living and Learning with New Media, by Mizuko Ito et al, Cambridge, MA: MIT Press, 2010
Authors: Huston Thomas Patrick 
Published: December 2020

Review of Hanging Out, Messing Around, and Geeking Out: Kids Living and Learning with New Media, by Mizuko Ito et al, Cambridge, MA: MIT Press, 2010.
Book Review: Promoting Teacher Reflection in Second Language Education: A Framework for TESOL Professionals, by Thomas S. C. Farrell, New York: Routledge ESL & Applied Linguistics Professional Series, 2015
Authors: Dimitrieska Vesna 
Published: December 2020

Review of Thomas S. C. Farrell's Promoting Teacher Reflection in Second Language Education: A Framework for TESOL Professionals, New York: Routledge ESL & Applied Linguistics Professional Series, 2015.
Japanese Recruitment Practices in Times of Crisis
Authors: Firkola Peter 
Published: December 2020

This paper examines past recruitment practices to provide insight into how Japanese companies have adapted during times of crisis. A literature review combining company surveys and government-related statistical data was used. It was found that many large companies adapted recruitment processes in varying degrees to deal with the changing economic environment. These changes include varying the number of hires and diversifying hiring conditions. Although many Japanese companies adapt their recruitment processes, they seem resistant to change their overall recruitment strategy even during a crisis.
Knowledge, Attitudes and Perception in Regard to COVID-19 Pandemic in Nigerian Military Population
Authors: Ogbole A. J. , Bisji J. S. , Umar S. J. , Jallo I. M. , Ezeh S. O. , James A. L. 
Published: December 2020

The study assessed the knowledge, attitudes and perception of Nigerian Military population towards the coronavirus outbreak. A web-based cross-sectional survey was used to collect from 216 data from military officers from the Nigerian Army, Nigerian Air Force and the Nigerian Navy. Majority of the study sample were males, 88.4% (n = 191) and more than half the respondents were between 21 to 30 years old (50.5%). Also, 82.4% of the sample were graduates and 54.2% married. 82.9% were from Nigerian Army and 57.9% were commissioned officers with 6-10 years’ work experience 49.5 (n=107). Results show that there was no significant correlation between demographic factors of gender, age, military type, religion, education and marital status and knowledge of COVID-19 (p>.05). Results further show that there was no significant correlation between demographic factors and perception of COVID-19 (p>.05), meaning there was no significant difference in perception of COVID-19 based on demographic factors. Finally, the results showed that there was no significant correlation between demographic factors and attitude to COVID-19 (p>.05). Irrespective of gender or age for example, knowledge, attitude, and perception of COVID-19 was good among the military population. Despites high level of awareness among the study population, it was recommended that the military authorities in Nigeria further strengthen their health systems, as well as the knowledge of infectious diseases and pandemics which will help them to assist the government and in educating the general populace through their military-civilian interface.
THE EFFECT OF WELFARE BENEFITS TOWARD EMPLOYEE PERFORMANCE AT PT. BANK PANIN, TBK IN MAKASSAR CITY
Authors: Nurlina . 
Published: December 2020

This study aims to determine the effect of welfare benefits toward employee performance at PT. Bank Panin, Tbk in Makassar City.
This research is a quantitative research. The population in this study were all employees at PT Bank Panin, Tbk in Makassar City, of 228 people. Then the sample is the author takes 20 percent of the population, of 46 people. Data collection methods are carried out by observation, documentation, and questionnaires. The data analysis technique used is a simple linear regression analysis for hypothesis testing.
The results showed that providing welfare benefits to employees had a positive and significant effect on employee performance at PT. Bank Panin, Tbk in Makassar City.
Characterization Shear Properties of PVC Foams Instrumented by Optical Fiber under Flexural Loading
Authors: Mharsi Karim , Chapeleau Xavier , Fajoui Jamal , Sellami Amira , Casari Pascal , Kchaou Mohamed 
Published: December 2020

Abstract
The bending behavior of foam core sandwich composites has increasingly attracted attention and application in industries such as shipbuilding, aircraft, and wind turbine industries. The main objective of this research work is the assessment of shear strain in a foam core beam by means of optical fiber sensors during a bending test. Experimental studies were conducted on a polyvinyl chloride (PVC) foam beam in which three optical fibers were embedded in a longitudinal plane across the thickness of the foam core; straight optical fibers measure strains due to the tension/compression load, whereas the sinusoidal fibers catch strains due to the shear load. A finite element model was used to predict strain levels in order to validate and explain optical fiber sensor measurements from three- and four-point bending tests. The concordance of the shear properties identified by optical fiber sensor results and obtained by finite element simulation was evaluated to validate the newly developed technique of characterization. Results shows good agreement between the experimental and numerical responses.
A Review of Polymer Electrets and Their Applications
Authors: Saxena Pooja , Shukla Prashant 
Published: December 2020

Abstract
This research focuses primarily on the uses of polymer electrets as an important class of organic materials finding their use in a variety of electronic and electrical engineering industries and ranging from photovoltaic cells to transducers, dosimeters, and other applications. This paper provides a broad summary about types of electrets and their mechanisms along with better knowledge of the electrical properties and detailed mechanisms involved in the buildup, transport, and storage of charges in organic polar polymers electrets. This work also aims to investigate the conditions favorable for obtaining long-lived electrets. This article highlights early research conducted in the field of electrets and reviews the current trends and applications of electrets in devices.
INHIBITION OF EARLY STAGES OF SALMONELLA TYPHIMURIUM BIOFILMS BY EXTRACELLULAR DNA (EDNA) AND GENOMIC DNA (GDNA)
Authors: Akçelik Nefise , Çelik Çiğdem Elif , Akçelik Mustafa 
Published: December 2020

In this study, the role of extracellular DNA in the establishment and maintenance of Salmonella biofilms was investigated. As a result of spectrophotometric measurements using PicoGreen® dye, it was determined that planktonic cells contain less eDNA compared to their biofilm counterparts. As a result of incubation at 20 °C for 24h, eDNA contents of planktonic Salmonella Typhimurium SL1344 and DMC4 cells were determined as 206 ng/ml and 211 ng/ml, respectively. However, eDNA amounts increases to 313.18 ng/ml for SL1344 and 319.37 ng/ml for DMC4 at biofilm structure of the same strains. The effects of extracellular DNA (eDNA) released from biofilm cells and genomic DNA (gDNA) isolated from Salmonella cells on the biofilm formation in the bacteria were investigated using DNase I and Benzonase enzymes that digest DNA. In the experiments where both enzymes were applied, the active fragmentation of eDNA and gDNA resulted in a statistically significant (p <0,01) decrease in biofilm formation at the end of 24 hours compared to non-enzyme treated samples, but this effect disappeared after 48 hours of incubation.
Findbuch des Bestandes Abt. 11
Authors: Rathjen Jörg 
Published: December 2020

Die Kanzlei wurde als oberste Justiz- und Verwaltungsbehörde für den königlichen Anteil von Schleswig und Holstein 1648 in Flensburg errichtet und 1649 nach Glückstadt verlegt. Ihre Zuständigkeit war seit 1713 auf Holstein beschränkt und wurde 1734 auf die Grafschaft Rantzau, 1762 auf die plönischen und 1774 auf die gottorfischen Lande ausgedehnt. Zugleich ersetzte man die Bezeichnung "Glückstädtische Regierung" durch "Holsteinische Landesregierung zu Glückstadt und Holsteinisches Oberkonsistorium". Die vorher formell unterschiedlichen besonderen Gerichte - Justizkanzlei, Oberamtsgericht, Pinnebergisches-, Altonaisches-, Rantzauisches Oberappellationsgericht - wurden 1806 als "Holsteinisches Obergericht" zusammengefasst. Seit 1816 hieß es "Holstein-Lauenburgisches Obergericht". Als 1834 in der mittleren Instanz Justiz und Verwaltung getrennt wurden, ging die Verwaltung an die Schleswig-Holsteinische Regierung auf Gottorf über; das Obergericht bestand als reine Justizbehörde fort.
Bei der Trennung von Justiz und Verwaltung im Jahr 1834 wurden die Akten geteilt. Die in Glückstadt verbliebenen Justizakten sind später größtenteils vernichtet worden, die Verwaltungsakten blieben erhalten und bilden den Kern des im Landesarchiv Schleswig-Holstein verwahrten Bestandes.