bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collective Deliberations and Hearts on Fire: Experiential Knowledge Among Entrepreneurs and Organisations in the Mental Health Service User Movement
Authors: Näslund Hilda 
Published: May 2020

AbstractPrevious research has shown that experiential knowledge plays an important role for service user movements and has also discussed ambiguities in the definition of this type of knowledge. This study contributes to clarifying how experiential knowledge is understood within the service user movement. Through semi-structured interviews, it explores how Swedish mental health service user organisations (MHSUOs) and service user entrepreneurs (SUEs) regard the role of experiential knowledge for their endeavours. The study shows that SUEs and MHSUOs view experiential knowledge as complementary to established medical and expert knowledge. Both groups further reflect on the functions of individual and collective dimensions of experiential knowledge. Emotions are important in conveying experiential knowledge, although emotional commitment can be short-lived. The study discusses challenges for SUEs and MHSUOs in developing strategies to manage risks tied to strategic essentialism, and also in maintaining a critical standpoint towards established service providers.
Investigation of Cerebral O-(2-[18F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models
Authors: Stegmayr Carina , Surges Rainer , Choi Chang-Hoon , Burda Nicole , Stoffels Gabriele , Filß Christian , Willuweit Antje , Neumaier Bernd , Heinzel Alexander , Shah N. Jon , Mottaghy Felix M. , Langen Karl-Josef 
Published: May 2020

Abstract

Purpose
A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [18F]FET may be a potential marker to localize epileptic foci.

Procedures
Five rats underwent kainic acid titration to exhibit 3 to 3.5 h of class IV–V motor seizures (status epilepticus, SE). Rats underwent 4× [18F]FET PET and 4× MRI on the following 25 days. Six rats underwent kindling with pentylenetetrazol (PTZ) 3 to 8×/week over 10 weeks, and hence, seizures increased from class I to class IV. [18F]FET PET and MRI were performed regularly on days with and without seizures. Four rats served as healthy controls. Additionally, five patients with focal epilepsy underwent [18F]FET PET within 12 days after the last documented seizure.

Results
No abnormalities in [18F]FET PET or MRI were detected in the kindling model. The SE model showed significantly decreased [18F]FET uptake 3 days after SE in all examined brain regions, and especially in the amygdala region, which normalized within 2 weeks. Corresponding signal alterations in T2-weighted MRI were noted in the amygdala and hippocampus, which recovered 24 days post-SE. No abnormality of cerebral [18F]FET uptake was noted in the epilepsy patients.

Conclusions
There was no evidence for increased cerebral [18F]FET uptake after epileptic seizures neither in the rat models nor in patients. The SE model even showed decreased [18F]FET uptake throughout the brain. We conclude that epileptic seizures per se do not cause a longer lasting increased [18F]FET accumulation and are unlikely to be a major cause of pitfall for brain tumor diagnostics.
Tensions in sustainable warehousing: including the blue-collar perspective on automation and ergonomic workplace design
Authors: Gruchmann Tim , Mies Annika , Neukirchen Thomas , Gold Stefan 
Published: May 2020

AbstractIn many industrial countries, demographic changes towards an aging society go hand in hand with the need for ergonomic workplaces. Therefore, it is necessary to rethink workplace designs and work processes, particularly in industrial professions, such as logistics. As logistics activities are still characterized by a high amount of manual effort, they represent a suitable field for gaining empirical insights into the implementation of automation and ergonomic practices to inform social sustainable warehousing logistics strategies. By assuming a paradox perspective, this study accordingly examines the research question to which extent tensions arise in the context of sustainable warehousing regarding the implementation of technical automation and improved ergonomic processes. To answer this question, automation and ergonomics practices are studied at two logistics service providers and an industrial manufacturer in Germany. By applying a mixed-methods approach, the study analyzes empirical data derived from semi-structured interviews with logistics and human resource managers at four warehouse sites of these companies. Besides identifying relevant criteria and paradoxical tensions in improving handling processes in the specific cases, technology alternatives were evaluated from blue-collar employees’ perspectives using an analytic hierarchy process (AHP) survey. The present study provides evidence that paradoxical tensions with regard to belonging and performing, as well as between organizational levels and through the change process itself are most important in this context. In this line, the current study contributes to theory and practice by providing insights into paradoxical tensions in warehousing logistics and discussing how automation and ergonomic transformational processes can be successfully managed through addressing interrelated demands of blue-collar workers, managers, and customers.
Alloy Stability of Ge1−xSnx with Sn Concentrations up to 17% Utilizing Low-Temperature Molecular Beam Epitaxy
Authors: Schwarz Daniel , Funk Hannes S. , Oehme Michael , Schulze Jörg 
Published: May 2020

AbstractThe binary alloy germanium tin has already been presented as a direct group IV semiconductor at high tin concentrations and specific strain. Therefore, it offers a promising approach for the monolithic integrated light source towards the optical on-chip communication on silicon. However, the main challenge faced by many researchers is the achievement of high tin concentrations and good crystal quality. The key issues are the lattice mismatch to silicon and germanium, as well as the limited solid solubility of tin in germanium of less than 1%. Therefore, this paper presents a systematic investigation of the epitaxial growth conditions of germanium tin with tin concentrations up to 17%. For this, we performed two growth experiments utilizing molecular beam epitaxy. In one experiment, we varied the growth temperature for the epitaxy of germanium tin with 8% tin to investigate the inter-growth temperature stability. In the second experiment, we focused on the strain-relaxation of germanium tin, depending on different tin concentrations and doping types. The results of subsequent material analysis with x-ray diffraction and scanning electron microscopy allow us to narrow the epitaxial window of germanium tin. Furthermore, we present a possible explanation for the unique relaxation mechanism of germanium tin, which is significantly different from the well-known relaxation mechanism of silicon germanium.
Organ function support in patients with coronavirus disease 2019: Tongji experience
Authors:   Multidisciplinary Team for COVID-19, Li Yong , He Fan , Zhou Ning , Wei Jia , Ding Zeyang , Wang Luyun , Chen Peng , Guo Shuiming , Zhang Binhao , Wan Xiaoning , Zhu Wei 
Published: May 2020

AbstractCoronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.
The Impact of Filter Settings on Morphology of Unipolar Fibrillation Potentials
Authors: Starreveld Roeliene , Knops Paul , Roos-Serote Maarten , Kik Charles , Bogers Ad J. J. C. , Brundel Bianca J. J. M. , de Groot Natasja M. S. 
Published: May 2020

AbstractUsing unipolar atrial electrogram morphology as guidance for ablative therapy is regaining interest. Although standardly used in clinical practice during ablative therapy, the impact of filter settings on morphology of unipolar AF potentials is unknown. Thirty different filters were applied to 2,557,045 high-resolution epicardial AF potentials recorded from ten patients. Deflections with slope ≤ − 0.05 mV/ms and amplitude ≥ 0.3 mV were marked. High-pass filtering decreased the number of detected potentials, deflection amplitude, and percentage of fractionated potentials (≥ 2 deflections) as well as fractionation delay time (FDT) and increased percentage of single potentials. Low-pass filtering decreased the number of potentials, percentage of fractionated potentials, whereas deflection amplitude, percentage of single potentials, and FDT increased. Notch filtering (50 Hz) decreased the number of potentials and deflection amplitude, whereas the percentage of complex fractionated potentials (≥ 3 deflections) increased. Filtering significantly impacted morphology of unipolar fibrillation potentials, becoming a potential source of error in identification of ablative targets.
Thermal maturity and TOC prediction using machine learning techniques: case study from the Cretaceous–Paleocene source rock, Taranaki Basin, New Zealand
Authors: Shalaby Mohamed Ragab , Malik Owais Ahmed , Lai Daphne , Jumat Nurhazwana , Islam Md Aminul 
Published: May 2020

AbstractThermal maturity, organic richness and kerogen typing are very important parameters to be evaluated for source rock characterization. Due to the difficulties of high cost geochemical analyses and the unavailability of rock samples, it was necessary to examine and test many different method and techniques to help in the prediction of TOC values as well as other maturity indicators in case of missing or absence of geochemical data. Integrated study of machine learning techniques and well-log data has been applied on Cretaceous–Paleocene formations in the Taranaki Basin, New Zealand. A novel approach of maturity prediction using Tmax and vitrinite reflectance (VR%) is the first and preliminary objective of this research. Moreover, the organic richness or the total organic carbon (TOC) content has been predicted as well. Geochemical and well-log data collected from the Cretaceous Rakopi and North Cape formations and Paleocene Mangahewa Formation have been processed and prepared to apply the machine learning techniques. Five machine learning techniques, namely Bayesian regularization for feed-forward neural networks (BRNNs), random forest (RF), support vector machine (SVM) for regression, linear regression (LR) and Gaussian process regression (GPR), were employed for prediction of TOC, Tmax and VR, and their results have been compared. For TOC prediction, the best model achieved the coefficient of determination (R2) value of 0.964 using RF model. For Tmax prediction, BRNN with one hidden layer achieved the R2 value of 0.828. BRNN with two hidden layers produced the best model for VR prediction achieving R2 = 0.636. A comparison of five ML techniques showed that all of these techniques performed exceedingly well for TOC prediction with a value of R2 > 0.96. In contrast, BRNN with one hidden layer was the only ML technique able to achieve R2 > 0.8 for Tmax and BRNN with two hidden layers was the only ML technique able to achieve R2 > 0.6 for VR prediction. Therefore, this research provides a strong empirical evidence that ML techniques can capture the nonlinear relationship between the well-log data and TOC as well as the maturity indicators which may not be fully understood by existing linear models.
Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn’s disease
Authors: Celentano V. , Kamil-Mustafa L. , Beable R. , Ball C. , Flashman K. G. , Jennings Z. , O’ Leary D. P. , Higginson A. , Luxton S. 
Published: May 2020

AbstractMeasurement of the psoas muscle area has been applied to estimate lean muscle mass as a surrogate marker of sarcopenia, but there is a paucity of evidence regarding the influence of sarcopenia on clinical outcomes following inflammatory bowel disease surgery. The aim of this study was to evaluate the association between MRI enterography defined sarcopenia and postoperative complications in patients undergoing elective ileocaecal resection for Crohn’s disease. To obtain cross sectional area measurement of the psoas muscle, the freehand area tool was used to trace the margin of each psoas muscle at the level of L4, with the sum recorded as Total Psoas Area (TPA). The total cross sectional muscle area of the abdominal wall was recorded as Skeletal Muscle Area (SMA), while myosteatosis was measured by normalising the psoas muscle intensity with the mean intensity of the cerebrospinal fluid. The primary outcome was the incidence of 30-day postoperative complications in patients in the lowest quartile of TPA and SMA. 31 patients were included and ten patients (32.25%) developed postoperative complications within 30 days of surgery. The cut-off values for the lowest quartile for TPA were 11.93 cm2in men and 9.77 cm2in women, including a total of 8 patients (25.8%) with 5 patients in this group (62.5%) developing postoperative complications and 3 patients (37.5%) Clavien-Dindo class ≥ 3 complications. The cut-off values for the lowest quartile for SMA were 73.49 cm2in men and 65.85 cm2in women, with 4 patients out of 8 (50%) developing postoperative complications. Psoas muscle cross sectional area and skeletal mass area can be estimated on Magnetic Resonance Enterography as surrogate markers of sarcopenia with high inter-observer agreement.
The trade patterns of the South China Sea during the Song period
Authors: Li Peining 
Published: May 2020

AbstractThis paper aims to outline two different trade patterns in the South China Sea during the Song period by examining the distribution pattern of cargos on the Intan, Cirebon, Nanhai No.1 (南海I号) and Quanzhou Bay 泉州湾 wrecks. Through the detailed analysis, it is argued that the voyage of some merchant ships would be conducted at the request of a single authority, from a few available, who handled bulk selling while the remaining spaces on the ship would be leased to some individual traders who did retail business. The major cargo on board would be aimed toward a single directional destination, as is represented by the Inan and Cirebon wrecks. In other cases, the sea-going journey would be a joint operation involving multiple traders and the major cargo would be handled by peddlers and possibly sold at a number of ports-of-call, as is seen with the Nanhai No.1 and Quanzhou Bay wreck.
Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID‐19)
Authors: Yang Lu‐Lu , Yang Ting 
Published: May 2020

AbstractAs a highly infectious respiratory tract disease, coronavirus disease 2019 (COVID‐19) can cause respiratory, physical, and psychological dysfunction in patients. Therefore, pulmonary rehabilitation is crucial for both admitted and discharged patients of COVID‐19. In this study, based on the newly released pulmonary rehabilitation guidelines for patients with COVID‐19, as well as evidence from the pulmonary rehabilitation of patients with severe acute respiratory syndrome, we investigated pulmonary rehabilitation for patients with COVID‐19 having complications, such as chronic pulmonary disease, and established an intelligent respiratory rehabilitation model for these patients.
Comparison between Tibetan and Small-tailed Han sheep in adipocyte phenotype, lipid metabolism and energy homoeostasis regulation of adipose tissues when consuming diets of different energy levels
Authors: Jing Xiaoping , Zhou Jianwei , Degen Allan , Wang Wenji , Guo Yamin , Kang Jingpeng , Liu Peipei , Ding Luming , Shang Zhanhuan , Qiu Qiang , Ding Xuezhi , Long Ruijun 
Published: May 2020

AbstractThis study aimed to gain insight into how adipose tissue of Tibetan sheep regulates energy homoeostasis to cope with low energy intake under the harsh environment of the Qinghai-Tibetan Plateau (QTP). We compared Tibetan and Small-tailed Han sheep (n 24 of each breed), all wethers and 1·5 years of age, which were each divided randomly into four groups and offered diets of different digestible energy (DE) densities: 8·21, 9·33, 10·45 and 11·57 MJ DE/kg DM. When the sheep lost body mass and were assumed to be in negative energy balance: (1) adipocyte diameter in subcutaneous adipose tissue was smaller and decreased to a greater extent in Tibetan than in Small-tailed Han sheep, but the opposite occurred in the visceral adipose tissue; (2) Tibetan sheep showed higher insulin receptor mRNA expression and lower concentrations of catabolic hormones than Small-tailed Han sheep and (3) Tibetan sheep had lower capacity for glucose and fatty acid uptake than Small-tailed Han sheep. Moreover, Tibetan sheep had lower AMPKα mRNA expression but higher mammalian target of rapamycin mRNA expression in the adipocytes than Small-tailed Han sheep. We concluded that Tibetan sheep had lower catabolism but higher anabolism in adipose tissue and reduced the capacity for glucose and fatty acid uptake to a greater extent than Small-tailed Han sheep to maintain energy homoeostasis when in negative energy balance. These responses provide Tibetan sheep with a high ability to cope with low energy intake and with the harsh environment of the QTP.
Detection of clinical bovine mastitis caused by Mycoplasma bovis in Brazil
Authors: Junqueira Nathália Brancato , Salina Anelise , Oliveira Gabriela Capriogli , Mettifogo Elena , Joaquim Sâmea Fernandes , Guimarães Felipe Freitas , Dalanezi Felipe Morales , Langoni Helio 
Published: May 2020

AbstractThe work reported in this research communication investigated the occurrence of Mycoplasma bovis (M. bovis) in milk samples from cows with clinical mastitis on dairy farms from seven Brazilian states. We hypothesized that M. bovis was present in bovine clinical mastitis milk in Brazil. A total of 561 milk samples were cultured on Hayflick agar and incubated in a microaerophilic atmosphere at 5% CO2. Polymerase chain reaction (PCR) was performed for the detection of Mycoplasma spp. and Mycoplasma bovis in milk samples. Mycoplasma spp. were isolated in 2% of the milk samples, and Mycoplasma bovis was verified in 3% of the milk samples by PCR. The results showed that Mycoplasma bovis is involved in clinical mastitis in Brazilian dairy herds. We emphasize the need for further studies to investigate the infection by this agent in clinical mastitis cases, particularly in Brazil, due to the lack of knowledge about its prevalence.
Economic Policy Uncertainty and Self-Control: Evidence from Unhealthy Choices
Authors: Kalcheva Ivalina , McLemore Ping , Sias Richard 
Published: May 2020

AbstractWe hypothesize that greater economic policy uncertainty (EPU) leads to increases in unhealthy behaviors by lowering individuals’ impulse control. Based on 6.1 million interviews over 22 years, our analysis reveals a positive relation between EPU and the propensity to make poor lifestyle choices, including higher rates of alcohol consumption, a larger number of drinks consumed, and greater binge drinking. EPU has long-lasting effects on drinking behavior, consistent with habit formation. Moreover, the relation is stronger for younger individuals whose habits are more malleable. We find similar results when using smoking rates to measure unhealthy choices.
Molecular survey on cattle and sheep hydatidosis and first detection ofEchinococcus canadensis(G6/G7) in sheep in Turkey
Authors: Mehmood Sarfraz , Simsek Sami , Celik Figen , Kesik Harun Kaya , Kilinc Seyma Gunyakti , Ahmed Haroon 
Published: May 2020

AbstractLarval stage of genus Echinococcus is the causing agent for the zoonotic infection which is life threatening known as Echinococcosis. The purpose of this study was the identification, molecular analysis and characterization ofEchinococcusspp. in sheep and cattle. The sampling was done from slaughterhouse of Elazig, Turkey. A total of 85 isolates (sheep,n= 19 and cattle,n= 66) have been collected after slaughtering. Following the gDNA isolation and PCR products of mt-CO1 gene (446 bp) of all the samples were sequenced. Out of 85 isolates, 84 were recognized asEchinococcus granulosus sensu strictoand one sheep isolate was found asEchinococcus canadensis(G6/G7 ) which is identified for the first time in Turkey. However, single nucleotide polymorphism has been observed not only in samples of different animals but also in samples collected from the same cattle. Six liver and three lung hydatid cysts have been detected in cattle. Although no nucleotide differences have been observed in the liver samples, there was single nucleotide polymorphism (C→T) in 40th nucleotide of two lung cysts. As a result of haplotype analysis, 16 haplotypes ofE. granulosus s.s.were detected in 66 cattle isolates whereas 7 haplotypes ofE. granulosus s.s.were identified in 19 sheep samples.
Evaluation of immune response toBacillus subtilisspores expressingClonorchis sinensisserpin3
Authors: Lin Zhipeng , Sun Hengchang , Ma Yan , Zhou Xinyi , Jiang Hongye , Wang Xi , Song Jiaman , Tang Zeli , Bian Qing , Zhang Zhen , Huang Yan , Yu Xinbing 
Published: May 2020

AbstractClonorchis sinensis(C. sinensis) is one of the most serious food-borne parasites, which can lead to liver fibrosis or cholangiocarcinoma. Effective measures for clonorchiasis prevention are still urgently needed.Bacillus subtilis(B. subtilis) is an effective antigen delivery platform for oral vaccines.Chonorchis sinensisserpin (CsSerpin) was proved to be potential vaccine candidates. In this study, CsSerpin3 was displayed on the surface ofB. subtilisspore and recombinant spores were orally administrated to BALB/C mice. CsSerpin3-specific IgA levels in faecal, bile and intestinal mucous increased at 4–8 weeks after the first administration compared with those in control groups. The mucus production and the number of goblet cells in intestinal mucosa elevated inB.s-CotC-CsSerpin3 (CotC, coat protein ofB. subtilisspore) spores treated group compared to those in blank control. No significant difference in the activities of glutamic-pyruvic transaminase/ alanine aminotransferase and glutamic oxalacetic transaminase/aspartate aminotransferase were observed between groups. There was no side effect inflammation and observable pathological damage in the liver tissue of mice after administration. Moreover, collagen deposition and Ishak score were statistically reduced inB.s-CotC-CsSerpin3 spores treated mice. In conclusion,B. subtilisspores displaying CsSerpin3 could be investigated further as an oral vaccine against clonorchiasis.