bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of influenza A virus-derived peptides on a rotavirus VP6-based delivery platform
Authors: Gröhn Stina , Heinimäki Suvi , Tamminen Kirsi , Blazevic Vesna 
Published: October 2020

AbstractRecombinant protein technology enables the engineering of modern vaccines composed of a carrier protein displaying poorly immunogenic heterologous antigens. One promising carrier is based on the rotavirus inner-capsid VP6 protein. We explored different VP6 insertion sites for the presentation of two peptides (23 and 140 amino acids) derived from the M2 and HA genes of influenza A virus. Both termini and three surface loops of VP6 were successfully exploited as genetic fusion sites, as demonstrated by the expression of the fusion proteins. However, further studies are needed to assess the morphology and immunogenicity of these constructs.
Progress in the R ecosystem for representing and handling spatial data
Authors: Bivand Roger S. 
Published: October 2020

AbstractTwenty years have passed since Bivand and Gebhardt (J Geogr Syst 2(3):307–317, 2000.10.1007/PL00011460) indicated that there was a good match between the then nascent open-source R programming language and environment and the needs of researchers analysing spatial data. Recalling the development of classes for spatial data presented in book form in Bivand et al. (Applied spatial data analysis with R. Springer, New York, 2008, Applied spatial data analysis with R, 2nd edn. Springer, New York, 2013), it is important to present the progress now occurring in representation of spatial data, and possible consequences for spatial data handling and the statistical analysis of spatial data. Beyond this, it is imperative to discuss the relationships between R-spatial software and the larger open-source geospatial software community on whose work R packages crucially depend.
Cost-effectiveness of hepatitis C virus screening, and subsequent monitoring or treatment among pregnant women in the Netherlands
Authors: Eijsink Job F. H. , Al Khayat Mohamed N. M. T. , Boersma Cornelis , ter Horst Peter G. J. , Wilschut Jan C. , Postma Maarten J. 
Published: October 2020

Abstract
Background
The prevalence of diagnosed chronic hepatitis C virus (HCV) infection among pregnant women in the Netherlands is 0.26%, yet many cases remain undiagnosed. HCV screening and treatment of pregnant HCV carriers could reduce the burden of disease and limit vertical transmission from mother to child. We assessed the impact of HCV screening and subsequent treatment with new direct-acting antivirals (DAAs) among pregnant women in the Netherlands.

Methods
An HCV natural history Markov transition state model was developed, to evaluate the public-health and economic impact of HCV screening and treatment. Besides all 179,000 pregnant women in the Netherlands (cohort 1), we modelled 3 further cohorts: all 79,000 first-time pregnant women (cohort 2), 33,000 pregnant migrant women (cohort 3) and 16,000 first-time pregnant migrant women (cohort 4). Each cohort was analyzed in various scenarios: i no intervention, i.e., the current practice, ii screen-and-treat, i.e., the most extensive approach involving treatment of all individuals found HCV-positive, and iii screen-and-treat/monitor, i.e., a strategy involving treatment of symptomatic (F1–F4) patients and follow-up of asymptomatic (F0) HCV carriers with subsequent treatment only at progression.

Results
For all cohorts, comparison between scenarios (ii) and (i) resulted in ICERs between €9,306 and €10,173 per QALY gained and 5 year budget impacts varying between €6,283,830 and €19,220,405. For all cohorts, comparison between scenarios (iii) and (i) resulted in ICERs between €1,739 and €2,749 per QALY gained and budget impacts varying between €1,468,670 and €5,607,556. For all cohorts, the ICERs (scenario iii versus ii) involved in delayed treatment of asymptomatic (F0) HCV carriers varied between €56,607 and €56,892, well above the willingness-to-pay (WTP) threshold of €20,000 per QALY gained and even above a threshold of €50,000 per QALY gained.

Conclusion
Universal screening for HCV among all pregnant women in the Netherlands is cost-effective. However, it would be reasonable to consider smaller risk groups in view of the budget impact of the intervention.
Hybrid approach to ventral wall hernia repair: a single-institution cohort study
Authors: Jamel Sara , Hakky Sherif Mohamad , Tukanova Karina , Huf Sarah , Markar Sheraz , Purkayastha Sanjay 
Published: October 2020

Summary
Background
Ventral hernias pose a substantial challenge for surgeons. Even though minimally invasive surgery and hernia repair have evolved rapidly, there is no standardised method that has been widely accepted as standard of practice. Hybrid ventral hernia repair (HVR) is an alternative surgical approach, which has not been adopted widely to date. It combines laparoscopic mesh insertion with closure of the hernia defect. The aim of this retrospective cohort study is to evaluate short- and long-term outcomes in patients undergoing HVR.

Methods
Between October 2012 and June 2016, 56 HVRs were performed at St Mary’s Hospital, Imperial College London. The medical records of these patients were reviewed retrospectively for demographics, comorbidities, previous surgeries, operative technique, complications and recurrences over a 3-year follow-up.

Results
HVRs were performed by four surgeons. Mean age was 48 years with a mean body mass index (BMI) of 32.8 kg/m2. 71.4% had incisional hernias and 28.6% had primary hernias. The number of hernia defects ranged from 1 to 4, with average defect size 42.9 cm2 (range 8–200 cm2). Adhesiolysis was performed in 66.1% of patients. Recurrence occurred in 2 patients (3.6%), 16.1% of patients developed postoperative seroma, 0.3% had respiratory complications, 0.3% had paralytic ileus and 0.2% had urinary retention. Only 2 patients required epidural postoperatively, both had a defect size of 150.0 cm2. There were no reoperations within 90 days. Mean length of hospital stay was 2 days (1–10 days). Over the follow-up period, 2 patients (3.6%) developed chronic pain.

Conclusion
The hybrid technique is safe and feasible, and has important benefits including low rates of seroma formation, chronic pain and hernia recurrence. Future investigations may include randomised controlled trials to evaluate the benefits of VHR, with careful assessment of patient-reported outcome measures including quality of life and postoperative pain.
The structure and functional correlates of social support networks of people in advanced old age living in chosen urban and rural areas in Poland: a cross-sectional study
Authors: Wojszel Z. B. , Politynska B. 
Published: October 2020

AbstractThe purpose of the study was to identify the different types of social support networks (SSNs) among community-dwelling people aged 75+ years in selected areas of Poland, and to evaluate any associations between the network type and demographic and health variables of the population studied. The two most prevalent SSN types identified using the Practitioner Assessment of Network Type were “family dependent” (35.8%) and “locally integrated” (32.2%). “Local self-contained” (6.4%), “wider community focused” (2.8%) and “private restricted” (5.6%) SSNs were observed less frequently. In 17.2% of cases, it was not possible to identify the type of network unequivocally. Older people with a locally integrated SSN, in contrast to the family dependent type, were generally younger, living alone, and less likely to be homebound, rate their health as poor, suffer from depression or dementia, and had lower levels of functional disability. Locally integrated SSNs are recognized in the literature as being the most robust in terms of facilitating well-being and providing sufficient support to help maintain the older person in the community. This may reflect the higher levels of independence of older people able to sustain these support networks, which are then transformed into family-dependent types as their health deteriorates, but confirmation of this would require prospective studies. An improved understanding of the prevalence of different types of social networks among older people in Poland would help to guide a systematic approach to recognizing unmet needs in this population and provide crucial information in the planning of formal services.
The Heritability of Type D Personality by an Extended Twin-Pedigree Analysis in the Netherlands Twin Register
Authors: Li-Gao Ruifang , Boomsma Dorret I. , de Geus Eco J. C. , Denollet Johan , Kupper Nina 
Published: October 2020

AbstractType D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiovascular disease. We aimed to (1) validate a new proxy based on the Achenbach System of Empirically Based Assessment (ASEBA) for Type D personality and its NA and SI subcomponents and (2) estimate the heritability of the Type D proxy in an extended twin-pedigree design in the Netherlands Twin Register (NTR). Proxies for the dichotomous Type D classification, and continuous NA, SI, and NAxSI (the continuous measure of Type D) scales were created based on 12 ASEBA items for 30,433 NTR participants (16,449 twins and 13,984 relatives from 11,106 pedigrees) and sources of variation were analyzed in the ‘Mendel’ software package. We estimated additive and non-additive genetic variance components, shared household and unique environmental variance components and ran bivariate models to estimate the genetic and non-genetic covariance between NA and SI. The Type D proxy showed good reliability and construct validity. The best fitting genetic model included additive and non-additive genetic effects with broad-sense heritabilities for NA, SI and NAxSI estimated at 49%, 50% and 49%, respectively. Household effects showed small contributions (4–9%) to the total phenotypic variation. The genetic correlation between NA and SI was .66 (reflecting both additive and non-additive genetic components). Thus, Type D personality and its NA and SI subcomponents are heritable, with a shared genetic basis for the two subcomponents.
The complete hierarchical locality of the punctured Simplex code
Authors: Grezet Matthias , Hollanti Camilla 
Published: October 2020

AbstractThis paper presents a new alphabet-dependent bound for codes with hierarchical locality. Then, the complete list of possible localities is derived for a class of codes obtained by deleting specific columns from a Simplex code. This list is used to show that these codes are optimal codes with hierarchical locality.
Mobility and the lifetime distributional impact of tax and transfer reforms
Authors: Levell Peter , Roantree Barra , Shaw Jonathan 
Published: October 2020

AbstractThis paper examines the lifetime distributional impact of changes to the tax and transfer system. We find that—in contrast to standard snapshot analyses—increases to work-contingent benefits are just as effective at redistributing resources to the lifetime poor as increases to out-of-work benefits. This has important implications for the equity-efficiency trade-off typically thought to apply to work-contingent transfers. We also show that increases to higher rates of income tax are an effective way of targeting the lifetime rich because higher earners tend to exhibit greater persistence in their incomes. Our results illustrate the importance that moving beyond an exclusively snapshot perspective can have when analysing tax and transfer reforms.
Joining of SiO2 glass and 316L stainless steel using Bi–Ag-based active solders
Authors: Weber Felix , Rettenmayr Markus 
Published: October 2020

AbstractActive brazing is a commonly used method for joining dissimilar materials with at least one non-metallic component. In the present study, joining of SiO2 glass to 316L stainless steel was performed utilizing Bi–Ag-based solders. Ti up to a concentration of 4 and Mg up to 1 wt.% were added as active elements. Microstructures of the solder alloys in the as-cast state and of cross sections of the joined compounds were analysed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. In the as-cast state of the solder, Ti is found in Bi–Ti intermetallic phases; Mg is partially dissolved in the fcc-(Ag) phase and additionally contained in a ternary Ag-Bi-Mg phase. After soldering, a tight joint was generated using several alloy compositions. Ti leads to the formation of reaction products at the steel/solder and glass/solder interfaces, and Mg is exclusively accumulated at the glass/solder interface.
LiYF4:Yb/LiYF4 and LiYF4:Yb,Er/LiYF4 core/shell nanocrystals with luminescence decay times similar to YLF laser crystals and the upconversion quantum yield of the Yb,Er doped nanocrystals
Authors: Carl Frederike , Birk Leonie , Grauel Bettina , Pons Monica , Würth Christian , Resch-Genger Ute , Haase Markus 
Published: October 2020

AbstractWe developed a procedure to prepare luminescent LiYF4:Yb/LiYF4 and LiYF4:Yb,Er/LiYF4 core/shell nanocrystals with a size of approximately 40 nm revealing luminescence decay times of the dopant ions that approach those of high-quality laser crystals of LiYF4:Yb (Yb:YLF) and LiYF4:Yb,Er (Yb,Er:YLF) with identical doping concentrations. As the luminescence decay times of Yb3+ and Er3+ are known to be very sensitive to the presence of quenchers, the long decay times of the core/shell nanocrystals indicate a very low number of defects in the core particles and at the core/shell interfaces. This improvement in the performance was achieved by introducing two important modifications in the commonly used oleic acid based synthesis. First, the shell was prepared via a newly developed method characterized by a very low nucleation rate for particles of pure LiYF4 shell material. Second, anhydrous acetates were used as precursors and additional drying steps were applied to reduce the incorporation of OH− in the crystal lattice, known to quench the emission of Yb3+ ions. Excitation power density (P)-dependent absolute measurements of the upconversion luminescence quantum yield (ΦUC) of LiYF4:Yb,Er/LiYF4 core/shell particles reveal a maximum value of 1.25% at P of 180 Wcm−2. Although lower than the values reported for NaYF4:18%Yb,2%Er core/shell nanocrystals with comparable sizes, these ΦUC values are the highest reported so far for LiYF4:18%Yb,2%Er/LiYF4 nanocrystals without additional dopants. Further improvements may nevertheless be possible by optimizing the dopant concentrations in the LiYF4 nanocrystals.
Percutaneous coronary intervention versus medical therapy for chronic total coronary occlusions: a systematic review and meta-analysis of randomised trials
Authors: van Veelen A. , Elias J. , van Dongen I. M. , Hoebers L. P. C. , Claessen B. E. P. M. , Henriques J. P. S. 
Published: October 2020

Abstract
Background
The results of chronic total occlusion percutaneous coronary intervention (CTO-PCI) trials are inconclusive. Therefore, we studied whether CTO-PCI leads to improvement of clinical endpoints and patient symptoms when combining all available randomised data.

Methods and results
This meta-analysis was registered in PROSPERO prior to starting. We performed a literature search and identified all randomised trials comparing CTO-PCI to optimal medical therapy alone (OMT). A total of five trials were included, comprising 1790 CTO patients, of whom 964 were randomised to PCI and 826 to OMT. The all-cause mortality was comparable between groups at 1‑year [risk ratio (RR) 1.70, 95% confidence interval (CI) 0.50–5.80, p = 0.40] and at 4‑year follow-up (RR 1.14, 95% CI 0.38–3.40, p = 0.81). There was no difference in the incidence of major adverse cardiac events (MACE) between groups at 1 year (RR 0.69, 95% CI 0.36–1.33, p = 0.27) and at 4 years (RR 0.85, 95% CI 0.60–1.22, p = 0.38). Left ventricular function and volumes at follow-up were comparable between groups. However, the PCI group had fewer target lesion revascularisations (RR 0.28, 95% CI 0.15–0.52, p < 0.001) and was more frequently free of angina at 1‑year follow-up (RR 0.65, 95% CI 0.50–0.84, p = 0.001), although the scores on the subscales of the Seattle Angina Questionnaire were comparable.

Conclusion
In conclusion, in this meta-analysis of 1790 CTO patients, CTO-PCI did not lead to an improvement in survival or in MACE as reported at long-term follow-up of up to 4 years, or to improvement of left ventricular function. However, CTO-PCI resulted in less angina and fewer target lesion revascularisations compared to OMT.
Effects of land use/land cover and climatic change on the ecosystem of North Ningxia, China
Authors: Abd El-Hamid Hazem T. , Caiyong Wei , Hafiz Mohammed A. , Mustafa Elhadi K. 
Published: October 2020

AbstractLand use/land cover change (LUCC) and climate changes are responsible for degradation of any ecosystem in arid and semi-arid regions. Studying the ecological variations is particularly essential for any type of sustainable development, in which LUCC considers as one of the chief inputs. The main objective is to evaluate the impacts of LUCC and climatic changes on the Ecosystem Vulnerability (ESV) using remote sensing and some statistical models around the Yellow River, Ningxia, China. Eleven classes of LUCC were identified during 1995 and 2019: village land, bare land, grassland, industrial land, irrigated land, swamp land, tidal flat, transportation land, urban land, water bodies, and water channels. Grassland may be decreased annually with percentage − 5.873% due to some human activities and environmental changes in climate from one season to another. About 24.23 km2and 24.86 km2was converted from grassland to industrial lands and irrigated lands, respectively. ESV has been calculated using LULC, DEM, slope, soil, and geology. About 45% and 60% of 1995 and 2019, respectively, undergone moderate vulnerability. The annual rate of ESVI decreased in low and reasonable but it was increased in moderate, high, and extreme showing – 4.166% as a total percentage of annual vulnerability. High vulnerability area needs proper management. Majority of vegetation area is located in zone under the moderate vulnerability zone; in contrast, grasslands were subjected to high vulnerability. Areas around the Yellow River were subjected to drought and flooding due to climatic change affecting negatively on the production of crops. Also, the desert lands of the study area have been turned to agriculture according to statistical model. Population growth, industrial development, and governmental policies for ecosystem protection were responsible for major changes. This study is more beneficial for decision-making in eco-environmental protecting and planning. Results of this study could help planners in formulating effective strategies for better management of ecosystem.
The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology
Authors: Zidovska Alexandra 
Published: October 2020

AbstractThe cell nucleus stores the genetic material essential for life, and provides the environment for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is filled with subnuclear bodies such as nucleoli that are responsible for other vital functions. Overall, the nucleus presents a highly heterogeneous and dynamic environment with diverse functionality. Here, we propose that its biophysical complexity can be organized around three inter-related and interactive facets: heterogeneity, activity, and rheology. Most nuclear constituents are sites of active, ATP-dependent processes and are thus inherently dynamic: The genome undergoes constant rearrangement, the nuclear envelope flickers and fluctuates, nucleoli migrate and coalesce, and many of these events are mediated by nucleoplasmic flows and interactions. And yet there is spatiotemporal organization in terms of hierarchical structure of the genome, its coherently moving regions and membrane-less compartmentalization via phase-separated nucleoplasmic constituents. Moreover, the non-equilibrium or activity-driven nature of the nucleus gives rise to emergent rheology and material properties that impact all cellular processes via the central dogma of molecular biology. New biophysical insights into the cell nucleus can come from appreciating this rich inner life.
Tracing of traffic-related pollution using magnetic properties of topsoils in Daejeon, Korea
Authors: Lee Seungwoo , Kim Seoyeon , Kim Hyeji , Seo Youlee , Ha Yeoncheol , Kim Hanul , Ha Raegyung , Yu Yongjae 
Published: October 2020

AbstractThe present study was designed to explore the possibility of roadside pollution screening using magnetic properties of topsoil samples in Daejeon, South Korea. Low-field magnetic susceptibility, frequency dependence of magnetic susceptibility, susceptibility of anhysteretic remanent magnetization, isothermal remanent magnetization (IRM) acquisition and demagnetization, back-field IRM treatment, and thermal demagnetization of composite IRM were determined for roadside topsoil samples. Magnetic susceptibility measured on 238 samples from the upper 5 cm of the topsoils ranged from 8.6 to 82.5 × 10–5 SI with a mean of 28.3 ± 10.8 × 10–5 SI. The proximal zone, 55 m wide area situated on either side of the main street, exhibited an enhancement of magnetic susceptibility. In areas distant from the main street, low magnetic susceptibility (< 50 × 10–5 SI) was observed. The topsoil samples exhibited significant susceptibility contrasts, suggesting that two dimensional magnetic mapping was effective in identifying traffic-related pollution. A few magnetic hotspots with intensities of magnetic susceptibility near or over 50 × 10–5 SI might reflect the difference in topographic elevation and surface morphology. Among various IRM-related parameters, remanence of coercivity was most significant statistically. In most samples, IRM component analysis provided dual coercivity components. Thermal demagnetization of composite IRM and morphological observation of magnetic separates suggest angular magnetite produced by vehicle non-exhaust emissions spherical magnetite derived from exhaust emission to be the dominant contributors to the magnetic signal. It is likely that lower- and higher-coercivity components represent the presence of coarse-grained angular magnetite and fine-grained spherical magnetite, respectively.
Emission taxes and feed-in subsidies in the regulation of a polluting monopoly
Authors: García-Alaminos Ángela , Rubio Santiago J. 
Published: October 2020

AbstractThe paper studies the use of emission taxes and feed-in subsidies for the regulation of a monopoly that can produce the same good with a technology that employs a polluting input and a clean technology. In the first part of the paper, we show that the efficient solution can be implemented combining a tax on emissions and a subsidy on clean output. The tax is lower than the environmental damages, and the subsidy is equal to the difference between the price and the marginal revenue. In the second part of the paper, the second-best tax and subsidy are also calculated solving a two-stage policy game between the regulator and the monopoly with the regulator acting as the leader of the game. We find that the second-best tax rate can be the Pigouvian tax, but only if the marginal costs of the clean technology are constant. Using a linear–quadratic specification of the model, we show that the clean output is larger when a feed-in subsidy is used than when the tax is applied, but the dirty output can be larger or lower depending on the magnitude of marginal costs of the clean technology and marginal damages. The same occurs for the net social welfare, although we find that for low enough marginal costs of the clean technology, the net social welfare is larger when a feed-in subsidy is used to promote clean output regardless the importance of the marginal damages.