bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Communication Initiatives amid COVID-19 in India: Analyzing Message Effectiveness of Videos on National Television
Authors: Purohit Neetu , Mehta Seema 
Published: August 2020

Communication for all hazards including widespread public health emergencies is a massive task. The crucial element is to reach and cover maximum people in a timely manner. This article is based on a systematic content analysis of videos on coronavirus disease (COVID-19) on National Television by Indian Public Service Broadcaster and Ministry of Health and Family Welfare. A total of 36 videos were telecasted on National Television channel Doordarshan from 3 March to 21 April 2020 in between programme breaks. The article analyses the presentation characteristics of these videos with respect to timing, duration, language, characters, format and key message content of communication videos on COVID-19. The article deliberates about the manner in which the chronology of the communication messages synced with the external events of the trajectory of the pandemic and thereby information-need of the community in India. All the messages which evolved in these videos (real and animated) were built on each other and depicted an information hierarchy (e.g., washing hands to social distancing) which could be viewed as an empowering tool for the community. The videos were analysed based on the nine constructs of conceptual model of emergency risk communication given by Seeger et al. (2018) . The key preventive messages in these videos focused on generating awareness, which was the fundamental necessity in view of the new type of pandemic like COVID-19. The summated scores show that 36 videos were appropriate up to 79 per cent times for the nine constructs, indicating the effectiveness of the messages in communicating the intended message as per the assessed construct. Limitations of the messages were primarily related to the inability to design communication messages with respect to specific understanding, needs and culture of the community.
Clinical and MRI characteristics of multiple sclerosis in patients of Middle Eastern and North African ancestry residing in Ontario, Canada
Authors: Seyman Estelle , Jones Ashley , Guenette Melanie , Vosoughi Reza , Selchen Daniel , Amezcua Lilyana , Baral Stefan , Oh Jiwon 
Published: August 2020

Background: Multiple sclerosis (MS) incidence is rising in traditionally low-burden regions, including the Middle East and North Africa (MENA). Objectives: Our objective was to evaluate disease characteristics in MS patients of MENA descent (MENA-MS). Methods: MENA-MS patients and age- and sex-matched MS patients of European descent (EUR-MS) were identified through the MS Clinic Registry of St. Michael’s Hospital in Toronto, Canada. Disease activity and severity were evaluated by the annualized relapse rate (ARR), magnetic resonance imaging (MRI) activity, change in the Expanded Disability Status Scale (EDSS), progression index (PI), and MS Severity Score (MSSS). Results: All MS patients within the registry identified to be of MENA origin ( n = 192), and age- and sex-matched EUR-MS patients were included. Mean age was 42.9 years, 67% female. A total of 25% and 24% of EUR-MS and MENA-MS had progressive disease, with similar mean disease durations (11.5 and 11.4 years, respectively). Clinical and radiological disease activity (ARR, proportion with new/enlarging MRI lesions) was similar. MENA-MS showed greater disability progression over time (EDSS change = 0.24 vs. 0.06, p = 0.01), a higher MSSS (3.12 vs. 2.67, p = 0.04), and higher PI (0.34 vs. 0.27, p = 0.07). Conclusion: MENA-MS patients demonstrate higher disease severity compared to EUR-MS patients, despite having similar inflammatory measures of disease activity, with disability progression in the absence of relapses. These observations illustrate the importance of the intersections of environmental, socioeconomic, and genetic determinants in optimizing individualized MS care.
Long intergenic non-protein coding RNA 00475 silencing acts as a tumor suppressor in glioma under hypoxic condition by impairing microRNA-449b-5p-dependent AGAP2 up-regulation
Authors: Yu Lei , Gui Si , Liu Yawei , Qiu Xiaoyu , Qiu Binghui , Zhang Xi’an , Pan Jun , Fan Jun , Qi Songtao , Zhang Guozhong 
Published: August 2020

Objective: Long non-coding RNAs have been demonstrated to be involved in the progression of a variety of cancers, including glioma. Through microarray analyses, long intergenic non-protein coding RNA 00475 (LINC00475) was identified in the glioma development. However, its potential role remains incompletely understood. This study aimed to elucidate the effect of LINC00475 on the development of glioma under hypoxic conditions. Methods: Glioma cells underwent hypoxic treatment and were collected. The functional role of LINC00475 and AGAP2 in glioma was determined using ectopic expression, depletion, and reporter assay experiments. Then, the expression of LINC00475, microRNA (miR)-449b-5p, AGAP2, FAK, and HIF-1α was determined. In addition, cell migration and invasion were examined. Finally, a tumor xenograft was carried out in nude mice to explore the role of LINC00475 on oxidation in vivo. Results: LINC00475 was identified to be overexpressed in hypoxic glioma samples, which was further observed to bind to and down-regulate miR-449b-5p, and negatively targeted AGAP2. Moreover, we also revealed a positive correlation between LINC00475 and AGAP2 expression in glioma. In addition, silencing of LINC00475 decreased the extent of FAK phosphorylation and reduced the expression of HIF-1α and AGAP2. It was also observed that LINC00475 silencing suppressed glioma cell proliferation, migration, and invasion, and promoted cell apoptosis. Moreover, oxidation of nude mice was promoted by LINC00475 silencing. Conclusion: Taken together, LINC00475 silencing exerted an inhibitory effect on glioma under hypoxic conditions by down-regulating AGAP2 via up-regulation of miR-449b-5p.
Orbital Implants in Orbital Fracture Reconstruction: A Ten-Year Series
Authors: Seen Sophia , Young Stephanie , Lang Stephanie S. , Lim Thiam-Chye , Amrith Shantha , Sundar Gangadhara 
Published: August 2020

Study Design: Retrospective comparative interventional series of all patients who had undergone orbital fracture repair by 2 senior orbital surgeons in a single tertiary trauma center from January 2005 to December 2014. Objective: To compare the outcomes of different implants used for various types of orbital fractures. Methods: Patients were evaluated by age, gender, etiology of fracture, clinical findings, type of fractures, and implant used. Main outcome measures included restoration of premorbid state without morbidity and complications including enophthalmos, diplopia, infraorbital hypoesthesia, and ocular motility restriction 1 year after fracture repair. Implant-related complications were collected for analysis. Results: There were a total of 274 patients with 307 orbits reconstructed. Thirty-three (12.0%) patients sustained bilateral injuries; 58.0% ( n = 178) of orbits had simple fractures (isolated orbital floor, medial wall, or combined floor and medial wall). The distribution of implants used were bioresorbable ( n = 117, 38.1%) and prefabricated titanium plates ( n = 98, 31.9%) depending upon the nature of fracture. Bioresorbables, titanium plate, and porous polyethylene were used significantly more than titanium mesh for simple fractures, and prefabricated anatomic titanium implants were used significantly more than the other implants for complex fractures. There was a statistically significant improvement in diplopia, enophthalmos, ocular motility, and infraorbital hypoesthesia ( p-value < 0.001) 1 year following orbital fracture reconstruction. Conclusions: When used appropriately, diverse alloplastic materials used in orbital fracture repair tailored to the indication aid orbital reconstruction outcomes with each material having its own unique characteristics.
Optimal diagnostic accuracy of quantitative faecal immunochemical test positivity thresholds for colorectal cancer detection in primary health care: A community‐based cohort study
Authors: Pin‐Vieito Noel , García Nimo Laura , Bujanda Luis , Román Alonso Begona , Gutierrez‐Stampa María Ángeles , Aguilar‐Gama Vanessa , Portillo Isabel , Cubiella Joaquín 
Published: August 2020

AbstractBackgroundOptimizing colonoscopy resources is challenging, and information regarding performing diagnostic quantitative faecal immunochemical test (FIT) in daily clinical practice in primary health care is still limited. This study aimed to assess the sensitivity, specificity, positive predictive value and negative predictive value of varying FIT positivity thresholds on colorectal cancer (CRC) detection in primary health care.MethodsA retrospective cohort study of 38,675 asymptomatic and symptomatic patients with a FIT (OC‐Sensor™) performed between 2012 and 2016 in a primary health‐care setting, using a clinical laboratory database of two Spanish areas linked with the National Health System's Hospital Discharge Records Database. The primary outcome was 2‐year CRC incidence.ResultsThe mean age of the participants was 63.2 years; 17,792 (46.0%) were male. CRC prevalence was 1.7% (650/38,675). The percentage of patients with a FIT result above the threshold was 20.7% and 14.6% for 10 μg Hb/g faeces and 20 μg Hb/g faeces thresholds, respectively. Sensitivity was 90.5% (95% confidence interval 88.0%–92.5%) at a 10 μg Hb/g faeces threshold, and this decreased by 3.1% when a 20 μg Hb/g faeces threshold was used. The negative predictive value for CRC was at least 99.2% in any subgroup analysed. At a 20 μg Hb/g faeces threshold, less than one additional CRC would be missed per 1000 patients investigated, while approximately 1.3 times more colonoscopy examinations were needed to identify an incidence of CRC using the lowest threshold for any situation analysed.ConclusionsIn primary health care, a quantitative FIT threshold should be tailored to colonoscopy capacity and CRC prevalence in specific populations.
Assessment of extraintestinal manifestations in inflammatory bowel diseases: A systematic review and a proposed guide for clinical trials
Authors: Guillo Lucas , D’Amico Ferdinando , Serrero Mélanie , Angioi Karine , Loeuille Damien , Costanzo Antonio , Danese Silvio , Peyrin‐Biroulet Laurent 
Published: August 2020

Background and aimsExtraintestinal manifestations are common in inflammatory bowel disease patients, although there are few data available on their diagnosis, management and follow‐up. We systematically reviewed the literature evidence to evaluate tools and investigations used for the diagnosis and for the assessment of the treatment response in inflammatory bowel disease patients with extraintestinal manifestations.MethodsWe searched in PubMed, Embase and Web of Science from January 1999–December 2019 for all interventional and non‐interventional studies published in English assessing diagnostic tools and investigations used in inflammatory bowel disease patients with extraintestinal manifestations.ResultsForty‐five studies (16 interventional and 29 non‐interventional) were included in our systematic review, enrolling 7994 inflammatory bowel disease patients. The diagnostic assessment of extraintestinal manifestations was performed by dedicated specialists in a percentage of cases ranging from 60–100% depending on the specific condition. The clinical examination was the most frequent diagnostic strategy, accounting for 35 studies (77.8%). In patients with primary sclerosing cholangitis or rheumatological symptoms, biochemical and imaging tests were also performed. Anti‐TNF agents were the most used biological drugs for the treatment of extraintestinal manifestations (20 studies, 44.4%), and the treatment response varied from 59.1% in axial spondyloarthritis to 88.9% in ocular manifestations. No benefit was detected in primary sclerosing cholangitis patients after treatment with biologics.ConclusionsIn the clinical management of inflammatory bowel disease patients with extraintestinal manifestations the collaboration of dedicated specialists for diagnostic investigations and follow‐up is key to ensure the best of care approach. However, international guidelines are needed to homogenise and standardise the assessment of extraintestinal manifestations.
Evaluation of EpiProtect® microbial cellulose burns dressings in young children
Authors: Shanks Lindsay A , Cronshaw Andrea , Alexander K Skaria , Davies Jonathan A , O’Boyle Ciaran P 
Published: August 2020

Introduction: EpiProtect® is a biosynthetic cellulose dressing indicated for the treatment of superficial burns and the dressing of deep burns. Prior to this study the youngest reported patient treated with EpiProtect® was aged 13 years. Method: Data were collected prospectively for patients aged < 5 years, presenting to the Children’s Burns Unit with ⩾ 2% total body surface area (TBSA) burns sustained by any mechanism. Results: Thirty children were treated (median age = 17 months, age range = 1–61 months). Thirty-six burn depths were documented: superficial partial thickness (SPT) in 53% (n=19); mid-partial thickness (MPT) in 33% (n=12); deep partial thickness (DPT) in 11% (n=4); and full thickness (FT) in 3% (n=1). Median burn size was 4.5% TBSA (range = 2%–12%). EpiProtect® was applied under general anaesthesia in all cases. The median length of stay (LOS) was two days (range = 0–6 days). EpiProtect® was tolerated well and provided effective analgesia for subsequent dressing changes. Median healing time was 13 days (SPT burns), 14 days (MPT) and 24 days (DPT burns). Three patients required split skin grafting. Hypertrophic scarring arose in one patient. Discussion: This case series represents the youngest published patient group to have been treated with EpiProtect®. Authors conclude that EpiProtect® provides a safe, reliable and well-tolerated dressing option for all burn depths in young children. Importantly, EpiProtect® is culturally neutral and may be used in situations which, for cultural reasons, may preclude the use of animal-derived products. Further studies are warranted to evaluate pain scores, burn depth, size and LOS correlation, and comparative analysis between dressing types. Lay Summary Burn injuries in the paediatric population are common and often require multiple dressing changes. Dressing changes can be painful and distressing to both children and their care givers. This article describes the experience of using a synthetically derived burns dressing, called EpiProtect®, in children aged ⩽ 5 years. Thirty patients were recruited with varying depths of scald burns and all underwent application of EpiProtect® dressing. The results suggested that EpiProtect® was a user-friendly dressing that can be used to treat partial-thickness burns and to dress full-thickness (FT) burns. It was well-tolerated and provided effective analgesia at the time of dressing changes. There was no incidence of increased burn wound infection rates and all wounds healed. In addition, as EpiProtect® is a synthetic product, it has the benefit of being culturally neutral, which is advantageous in a culturally diverse population. Further studies are warranted to evaluate the effectiveness of this dressing and to compare it to similar dressings that are available.
A Review of Empirical Research on Transformational School Leadership in China (2010–2019)
Authors: Li (李艳征) Yanzheng 
Published: August 2020

Purpose: The purpose of this literature review is to investigate the effectiveness of transformational school leadership (TSL) in Chinese K–12 settings between 2010 and 2019. The main objective is to provide a comprehensive understanding of TSL research in China and identify the possible future research directions. Design/Approach/Methods: Vote counting method and narrative synthesis were applied in this review. Findings: This review found the majority of the studies were quantitative, which indicates that qualitative and mixed-method studies should be encouraged. This review also identified 12 major outcome variables, including 9 teacher-level variables, 2 school-level variables, and 1 student-level variable. Additionally, the effects of transformational leadership on these outcome variables were uniformly significant, including both direct and indirect effects. Future studies should expand the scope of school-level and student-level outcome variables, but particularly student-level outcome variables. Originality/Value: This is the first systematic review on the effectiveness of TSL research in China, which included both English and Chinese studies.
Ergonomics
Authors: Sluchak Thomas J. 
Published: August 2020

Ergonomics is not a panacea. Ergonomics focuses first on fitting the job to the worker, then on fitting the worker into the job. The appropriate application of ergonomic principles, while keeping in mind the individual differences among workers, will lead to improvement in the health and safety of any occupational setting. Perhaps the real significance of ergonomic programs is best considered in light of the possible alternatives. These words from Weiner (1950), also cited by Christensen (1987), sum up the problem of taking a narrow, short term view of the workplace, and the consequences of failing to actively strive for improved ergonomic working conditions: It is a degradation to a human being to chain him to an oar and use him as a source of power; but it is an almost equal degradation to assign him purely repetitive tasks in a factory, which demand less than a millionth of his brainpower. But it is simpler to organize a factory or galley which uses individual human being for a trivial fraction of their worth than it is to provide a world in which they can grow to their full stature (Weiner, 1950).
Total Quality Management in American Industry
Authors: Widtfeldt Anne Keenan , Widtfeldt James R. 
Published: August 2020

Occupational health nurses must apply the universal principles of Total Quality Management so that health services are customer driven, value added, process focused, and statistically measured. They must elicit customer input prior to, along with, and after program implementation. Programs must be directed toward doing the right things and doing things right. Measurement must be a priority of any program in health services. If occupational health nurses do all this, they will be at the forefront of the American quality movement, especially as it relates to health care.
Implementing a University Campus Wellness Model
Authors: Bruce Glenda M. 
Published: August 2020

This university wellness model symbolizes self responsibility and control of one's life while riding toward wellness. The number of concepts it contains makes it reasonably simple to implement. All of the major concepts of the model are well defined, resulting in a clear, descriptive picture of how program development should proceed. The model allows easy visualization of the interaction among concepts. In view of the broad scope of the model's concepts and its simplicity, the model could be applied to other workplace situations. Minor program component adjustments may be needed to meet the specific needs of the workplace. The model provides a general framework to guide the planning phase, whether that planner be an occupational health nurse, health officer, or exercise physiologist. This model may apply and be of significance to those who are interested in increasing worker productivity and decreasing employer costs. It may be of particular interest to the nursing profession to generate innovative ideas to help the working populace stay healthy, despite today's crisis of diminishing health care dollars.
Case Management in a Health Maintenance Organization
Authors: Leigh Betsy 
Published: August 2020

The planning and implementation of this case management model brought together a mul-tidisciplinary team with a common goal of providing a positive health care experience for the injured worker. The challenge of implementation of a case management model within a large, complex health care system has resulted in successful changes. For example, referral tracking has been improved due to the expected outcome of quality case management. The difficulties encountered due to the previous lack of consistency in occupational services within the seven occupational health clinics became an immediate concern with the implementation of the model. The formulation of the Standard Operating Procedures became a priority focus. Inconsistencies in service delivery have been identified and corrected by the development and implementation of regionally driven Standard Operating Procedures. Complex group process and interdepartmental communication efforts have resulted in more standardized health care for the clients. Community outreach with employer groups has been enhanced, providing a close liaison with the occupational health care team. Improved information exchange assists in ongoing monitoring of complicated cases and earlier problem resolution. The projected outcome is improved quality of care for the injured worker and a return to an optimal state of health and productivity.
Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies
Authors: Jain Tania , Knezevic Andrea , Pennisi Martina , Chen Yunxin , Ruiz Josel D. , Purdon Terence J. , Devlin Sean M. , Smith Melody , Shah Gunjan L. , Halton Elizabeth , Diamonte Claudia , Scordo Michael , Sauter Craig S. , Mead Elena , Santomasso Bianca D. , Palomba M. Lia , Batlevi Connie W. , Maloy Molly A. , Giralt Sergio , Smith Eric , Brentjens Renier , Park Jae H. , Perales Miguel-Angel , Mailankody Sham 
Published: August 2020

Abstract
Factors contributing to hematopoietic recovery following chimeric antigen receptor (CAR) T-cell therapy have not been well studied. In an analysis of 83 patients with hematologic malignancies treated with CAR T-cell therapy, we describe patterns of hematopoietic recovery and evaluate potentially associated factors. We included patients who received axicabtagene ciloleucel (n = 30) or tisagenlecleucel (n = 10) for B-cell lymphoma, CD19-28z CAR T therapy for B-cell acute lymphoblastic leukemia (NCT01044069; n = 37), or B-cell maturation antigen targeting CAR T cells for multiple myeloma (NCT03070327; n = 6). Patients treated with CAR T cells who had not progressed, died, or received additional chemotherapy had “recovered” (per definition in Materials and methods section) hemoglobin, platelet, neutrophil, and white blood cell counts at rates of 61%, 51%, 33%, and 28% at month 1 postinfusion and 93%, 90%, 80%, and 59% at month 3 postinfusion, respectively. Univariate analysis showed that increasing grade of immune effector cell–associated neurological syndrome (ICANS), baseline cytopenias, CAR construct, and higher peak C-reactive protein or ferritin levels were statistically significantly associated with a lower likelihood of complete count recovery at 1 month; a similar trend was seen for cytokine release syndrome (CRS). After adjustment for baseline cytopenia and CAR construct, grade ≥3 CRS or ICANS remained significantly associated with the absence of complete count recovery at 1 month. Higher levels of vascular endothelial growth factor and macrophage-derived chemokines, although not statistically significant, were seen patients without complete count recovery at 1 month. This remains to be studied further in larger prospective studies.