bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of miR-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses
Authors: Miao Xiaolin , Tong Xinyun , Hu Jingsang , Wang Juan 
Published: July 2020

Abstract
Background: Psoriasis is a multifactorial, recurring, and chronic inflammatory skin disease. This study was designed to explore the potential role of microRNA-106a-5p (miR-106a-5p) in psoriasis.Methods: The expression levels of miR-106a-5p in the serum of psoriasis patients and healthy individuals were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The diagnostic value of miR-106a-5p in serum was evaluated by the receiver operating characteristics curve (ROC). The levels of interleukin-22 (IL-22), interleukin-17A (IL-17A), and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay.Results: The serum expression of miR-106a-5p was found to be up-regulated in psoriasis patients. ROC curve showed that miR-106a-5p had high specificity and sensitivity in the diagnosis of psoriasis. The correlation between the serum expression level of miR-106a-5p and PASI was positive. The relative expression levels of IL-17A, IL-22 and TNF-alpha in serum of psoriasis patients were significantly upregulated compared with that in healthy control, and showed positive association with serum miR-106a-5p levels. Cell experiments demonstrated that upregulation of miR-106a-5p could promote cell proliferation, and the levels of IL-22, IL-17A and TNF-alpha were upregulated significantly in M5-induced HaCaT cells.Conclusion: Considering the novel and vital role in psoriasis progression, miR-106a-5p is expected to be a new potent target for treatment of psoriasis. MiR-106-5p was expected to use for more immunity diseases research and therapy.
A diagnostic pitfall in hepatic mesenchymal hamartoma mimicking hepatoblastoma: A case report
Authors: Chen Zhihong , Fang Lutong , Zhang Ying , Ye Yuanzi , Ji Wenshu , Meng Gang 
Published: July 2020

Abstract
Background: Hepatic mesenchymal hamartoma (HMH) is an uncommon benign tumor in children. While mesenchymal hamartomas may be angiomatous and blood vessels may be identified, HMH with a malignant tumor symptom on the contrast-enhanced hepatic computed tomography angiography (CTA) has not been described. Here, we present the first case of HMH mimicking hepatoblastoma on the hepatic CTA from pathological point of view and review the imaging and histological features of this unique lesion. Case presentation: A 2-year-old female child was found a distention in the right abdomen and was admitted to our hospital. The Hepatic CTA showed that the blood vessels were thickened, the tumor blood vessels were clustered in the tumor. According to the hepatic CT findings, the tumor was considered to be malignant, possibly a hepatoblastoma. Microscopic examination showed a tumor arranged in lobules, composed of loose myxoid mesenchyme surrounding ductal structures, with intervening vascular channels. The Immunohistochemical staining revealed positive CK7 and CD34 for the bile duct elements and the lining endothelial cells of the vascular channels. There were abundant blood vessels around the nodules and the margins of remaining hepatocytes, but few in the central region. The blood vessels are small, thin-walled vessels and presented like capillaries and venules. Conclusions: A histological diagnosis of Hepatic Mesenchymal Hamartoma was confirmed by the microscopic examinations. This case adds learning points to radiologists when heterogeneous reinforcement on enhanced CT scan was presented in such a large childhood liver tumor.
Community-Based Peer Support Intervention to Mitigate Social Isolation and Stigma of Adolescent Motherhood in Harare, Zimbabwe
Authors: Tinago Chiwoneso B. , Frongillo Edward A. , Warren Andrea , Chitiyo Vivian , Cifarelli Ashley K. , Fyalkowski Shannon , Pauline Victoria 
Published: July 2020

Abstract
Background Adolescent mothers in Zimbabwe often experience isolation and lack coping skills and resources to successfully navigate motherhood. To develop a community-based peer support intervention, we need to understand the unique needs of adolescent mothers and how peer support groups could address those needs. Methods Focus group discussions were conducted with 85 adolescent mothers aged 14-18 years, 24 community health workers, and 25 key community stakeholders in a low-income high-density community in Harare. Data were analyzed thematically using NVivo 12 software. Results Participants described adolescent motherhood challenges and gaps in services and programming. Participants preferred bi-weekly one-hour group sessions addressing topics including income generation, mental health, and gossip, facilitated by community health workers at health and community centers. Use of WhatsApp Messenger to support intervention efforts was welcomed as an affordable and user-friendly platform to share information. Conclusions Adolescent mothers need strong adult community support and health knowledge to address important social issues that impact their health and well-being. Facilitated peer support groups can strengthen social networks and mitigate the adverse effects of social isolation and stigma among adolescent mothers. The community supported participatory engagement that empowers, meets needs, and improves the health of adolescent mothers.
Clopidogrel Versus Ticagrelor in the Treatment of Patients Undergoing Percutaneous Coronary Intervention: Effects on Platelet Function Assessed by Platelet Function Tests and Mean Platelet Volume.
Authors: Zhang Yang , Peng Rui , Li Xiaojuan , Cheng Gaowa , Wang Ximing , Yu Jinxing , Hua Muxing , Chen Xi , Zhou Zhou 
Published: July 2020

Abstract
Background: Knowledge on the pharmacodynamic effects of antiplatelet drugs including clopidogrel and ticagrelor on Asian patients is scarce. We aim to evaluate the effects of the two drugs on platelet reactivity in the treatment of Chinese patients who underwent percutaneous coronary intervention (PCI), using two platelet function tests (PFT). Meanwhile, the relationship between mean platelet volume (MPV), a routinely index of platelet size, and high on-treatment platelet reactivity (HPR) is also investigated.Methods: Patients receiving dual antiplatelet therapy (DAPT) treatment were scheduled for the assessment of platelet reactivity at 2-3 days after PCI. Two PFTs, light transmission aggregometry (LTA) and vasodilator-stimulated phosphoprotein (VASP) assay, were applied in the evaluation of platelet reactivity. MPV was measured simultaneously.Results: The final study population included the traditional therapy group with aspirin and clopidogrel (n = 46) and the new therapy group with aspirin and ticagrelor (n = 66). In the new therapy group, the value of platelet aggregation assessed by LTA was obviously lower than that in the traditional therapy group (P < 0.001). The platelet reactivity index (PRI) level at VASP test was also markedly lower in the group given the new therapy (P < 0.001). It presented significant difference of HPR rates between the two groups. MPV showed a potent ability in predicting the presence of HPR at VASP assay (AUC = 0.788, 95% CI: 0.701-0.875, P < 0.001) in receiver-operating characteristic curve analysis.Conclusions: Compared with clopidogrel, ticagrelor has dramatically greater antiplatelet effect, with a superiority of suppressing platelet function and a lower HPR rates. In addition, there existed a significantly independent association between MPV and high prevalence of HPR at VASP assay.
A procedure for stable electrical measurements on a rock sample against high contact resistance as a prerequisite for electrical tomography
Authors: Suzuki Takeshi , Yoshimura Ryokei , Yamazaki Ken'ichi , Oshiman Naoto 
Published: July 2020

Abstract
An important geophysical issue is determining the resistivity of rocks under various conditions. To characterise the internal resistivity structure of a rock needs electrical data from many small electrodes attached around its surface. Effective measurement must overcome the high resistance of the rock itself and the high contact resistance on the rock’s surface during measurement. Therefore, we developed a new method for stable, multi-point, electrical measurement on rock samples that is effective at high contact and sample resistance. The method employed conductive, adhesive epoxy electrodes, which strongly attached even to dry rock surfaces and provided high conductivity. Sustained current injection for long periods into high-resistance rocks was fulfilled using a constant direct current source with high internal resistance. Accurate voltage measurement across the high-resistance rock was accomplished by differential measurement using two high input resistance voltmeters. Measurements of high resistance also require a stable measurement environment: the temperature and humidity in the laboratory were controlled using an air conditioner, a humidifier, a dehumidifier, and a vinyl tent. Signal noise arising from human activities was eliminated by the remote operation of the measuring equipment and switching terminal. We assessed the precision and stability of our new method when applied to a dry granite sample at various levels of absolute humidity. The method recorded highly reproducible measurements under all absolute humidity conditions, thus indicating its validity. The observed changes of measured values with absolute humidity showed that atmospheric moisture greatly influences a sample’s resistance and contact resistance, and indicate the importance of stabilising the temperature and humidity conditions in the laboratory when taking electrical measurements of dry rocks at room temperature and pressure. Additional electrical measurement of dry granite using a simple electrode array constituted the first step toward electrical tomography measurements. A 40-electrode array acquired the potential distribution on the granite’s surface in response to injected current. Sample resistivity, which was sufficient to explain the measured potential distribution, was estimated by forward modelling. This demonstrates the robustness of our method, and indicates that it is potentially applicable to electrical tomography.
A Novel Small Molecule CXCR4 Antagonist Potently Mobilizes Hematopoietic Stem Cells in Mice and Monkeys
Authors: Fang Xiao , Fang Xiong , Mao Yujia , Ciechanover Aaron , Xu Yan , An Jing , Huang Ziwei 
Published: July 2020

Abstract
Background Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for current HSC transplantation. However, PB usually contains very few HSCs under normal conditions, as these cells are normally retained within the BM. This retention depends on the interaction between the CXC chemokine receptor 4 (CXCR4) expressed on the HSCs and its natural chemokine ligand, stromal cell-derived factor (SDF)-1α (also named CXCL12) present in the BM stromal microenvironment. In clinical practice, blocking this interaction with a CXCR4 antagonist can induce the rapid mobilization of HSCs from the BM into the PB.Methods C3H/HEJ, DBA/2, CD45.1+, CD45.2+ mice and monkeys were employed in colony-forming unit (CFU) assays, flow cytometry assays, and competitive/non-competitive transplantation assays, to assess the short-term mobilization efficacy of HF51116 and the long-term repopulating (LTR) ability of HSCs. Kinetics of different blood cells and the concentration of HF51116 in PB were also explored by blood routine examinations and pharmacokinetic assays. Results In this paper, we report that a novel small molecule CXCR4 antagonist, HF51116, which was designed and synthesized by our laboratory, can rapidly and potently mobilize HSCs from BM to PB in mice and monkeys. HF51116 not only mobilized HSCs when used alone but also synergized with the mobilizing effects of granulocyte-colony stimulating factor (G-CSF) after co-administration. Following mobilization by HF51116 and G-CSF, the long-term repopulating (LTR) and self-renewing HSCs were sufficiently engrafted in primary and secondary lethally irradiated mice and were able to rescue and support long-term mouse survival. In monkeys, HF51116 exhibited strong HSC mobilization activity and quickly reached the highest in vivo blood drug concentration. Conclusions These results demonstrate that HF51116 is a new promising stem cell mobilizer which specifically targets CXCR4 and merits further preclinical and clinical studies.
Effects of Amyloid Light-chain Amyloidosis on Clinical Characteristics and Prognosis in Multiple Myeloma: A Single-center Retrospective Study
Authors: Xu Junhui , Wang Mangju , Shen Ye , Yan Miao , Xie Weiwei , Wang Bingjie , Song Zhengyang , Liu Huihui , Cen Xinan 
Published: July 2020

Abstract
Background

Amyloid light-chain amyloidosis (AL amyloidosis) is commonly associated with multiple myeloma. However, the clinical characteristics and prognosis of multiple myeloma with AL amyloidosis are not particularly clear.
Methods

Patients with multiple myeloma in the Peking University First Hospital registry from 2010 to 2018 were studied. The clinical and laboratory information were collected from first presentation to death or until the last available clinical follow-up. The patients’ survival and outcomes were analyzed, and the relationships between the clinical parameters and survival were also assessed.
Results

Compared with patients without AL amyloidosis, patients with AL amyloidosis had higher incidence of BNP ≧ 1000 pg/ml (P = 0.001), ALP > 187.5 IU/L (P = 0.002) and ALB < 35 g/L (P = 0.001), but lower incidence of HB < 85 g/L (P = 0.031), hypercalcemia > 2.65 mmol/L (P = 0.008), bone destruction more than three (P < 0.001), bone marrow plasma cell ratio ≧ 30% (P < 0.001) and worse D-S stage (P < 0.001). Multiple myeloma was more often complicated by λ-type AL amyloidosis than κ-type AL amyloidosis. However, further comparison found that multiple myeloma with κ-type AL amyloidosis had higher incidence of ALP > 187.5 IU/L (P = 0.001) and renal insufficiency (P = 0.001) along with worse D-S stage (P = 0.003) than multiple myeloma with λ-type AL amyloidosis. Renal biopsies of many patients suggested AL amyloidosis, but their bone marrow biopsies or subcutaneous abdominal fat pad aspirates results were negative. The existence of AL amyloidosis especially the heart involvement was related to shorter long-term survival of multiple myeloma according to univariate analysis. Cox regression model for overall survival detected the presence of AL amyloidosis in multiple myeloma having independent prognostic significance (RR = 4.52, P = 0.049).
Conclusions

Patients with multiple myeloma accompanied by AL amyloidosis have milder target organ damage and lower tumor burden. The incidence of AL amyloidosis in κ-type multiple myeloma is lower but more severe than λ-type multiple myeloma. Renal biopsy can help to identify patients with AL amyloidosis. AL amyloidosis is an independent poor prognostic factor for multiple myeloma is mainly because involvements of important organs especially the heart.
Developing the nomogram for the prediction of in-hospital incidence of acute respiratory distress syndrome in patients with COVID-19
Authors: Ding Ning , Zhou Yang , Yang Guifang , Guo Cuirong , Tang Fengning , Chai Xiangping 
Published: July 2020

Abstract
Background: Acute respiratory distress syndrome (ARDS) was the most common complication of coronavirus disease-2019(COVID-19), leading to poor clinical outcomes. However, the model to predict the in-hospital incidence of ARDS in patients with COVID-19 is limited. Therefore, we aimed to develop a predictive nomogram for the in-hospital incidence of ARDS in COVID-19 patients.Methods: Patients with COVID-19 admitted to Changsha Public Health Centre between Jan 30, 2020, and Feb 22, 2020, were enrolled. Clinical characteristics and laboratory variables were analyzed in patients with ARDS. Risk factors for ARDS were selected by LASSO binary logistic regression. Nomogram was established based on risk factors and validated by the dataset.Results: A total of 113 patients, involving 99 in the non-ARDS group and 14 in the ARDS group were included in the study. 8 variables including hypertension, chronic obstructive pulmonary disease (COPD), cough, lactate dehydrogenase (LDH), creatine kinase (CK), white blood count (WBC), body temperature, and heart rate were identified to be included in the model. The specificity, sensitivity, and accuracy of the full model were 100%, 85.7%, and 87.5% respectively. The calibration curve also showed good agreement between the predicted and observed values in the model.Conclusions: The nomogram can predict the in-hospital incidence of ARDS in COVID-19 patients. It helps physicians to make an individualized treatment plan for each patient.
Short Term Stress of COVID-19 on World Major Stock Indices
Authors: Rehan Muhammad , Alvi Jahanzaib , KARACA  
Published: July 2020

Abstract
The main objective of this study is to check short term stress of COVID-19 on the American, European, Asian, and Pacific stock market indices, furthermore, the correlation between all the stock markets during the pandemic. Secondary data of 41 stock exchange from 32 countries have been collected from investing.com website from 1st July 2019 to 14th May 2020 for the stock market and the COVID-19 data has been collected according to the first cases reported in the country, stocks market are classified either developed or emerging economy, further divided according to the subcontinent i.e. America, Europe, and Pacific/Asia, the main focus in the data is the report of first COVID-19 cases. The study reveals that there is volatility in the all the 41 stock market (American, Europe, Asia, and Pacific) after reporting of the first case and volatility increase with the increase of COVID-19 cases, moreover, there is a significant negative relationship between the number of COVID-19 cases and 41 major stock indices of American, Europe, Asia and Pacific, European subcontinent market found more effected from the COVID-19 than another subcontinent, there is Clustering effect of COVID-19 on all the stock market except American's stock market due to smart capital investing.
SWOT-TOWS analysis to improve home health waste management during the COVID-19 pandemic
Authors: Silva Thais , Maciel Renata , Florencio Lourdinha , Santos Simone Machado 
Published: July 2020

Abstract
Home health services are of great concern, as infectious diseases can be transmitted not only to residents but also to home health care workers. Worldwide, there are few studies related to home health waste management. Before the COVID-19 pandemic, a survey on waste management from home health care services was carried out between October and December 2019. In the survey, all 67 stakeholders (health teams and caregivers/patients) involved in home health care services in the municipality of Caruaru (Brazil) were interviewed. The collected data showed that the home health care and waste management practices identified during field visits would be severely impacted by the pandemic. In this context, a SWOT analysis and TOWS matrix were employed in the analysis of home health care practices; in this work, those practices include care provided by health teams and patient caregivers, encompassing the handling of waste resulting from health care. The results show the need to promote strategies to improve home health care services to preserve the health of professionals and patients in the pandemic and post-pandemic periods. In this context, care related to the transmission of COVID-19 has been ratified, generating additional actions for the proper management of health waste.
The interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) and variant of Cocaine and Amphetamine-Regulated Transcript Prepropeptide (CARTPT) 5q13-14 - rs2239670 locus on hypothalamic-pituitary axis hormones and metabolic risk factors in obese individuals
Authors: Khodarahmi Mahdieh , Farhangi Mahdieh , Niknam Mahdi 
Published: July 2020

Abstract
BackgroundEpidemiological studies have illustrated that polymorphisms of Cocaine and Amphetamine-Regulated Transcript Prepropeptide gene (CARTPT) may affect obesity outcomes. However, no study has investigated the CARTPT gene-diet interactions in term of antioxidant potential of diet. This study aimed to evaluate the interactions between CARTPT gene and dietary non-enzymatic antioxidant capacity on hypothalamic- pituitary axis hormones and cardio-metabolic risk factors. Method and MaterialIn the present cross-sectional study, 288 apparently healthy obese adults aged 20–50 years with a body mass index (BMI) of 30–40 kg/m2 completed the study. Dietary assessment was performed by food frequency questionnaire (FFQ) and antioxidant capacity of diet was estimated by calculating the oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), total radical trapping antioxidant parameter (TRAP) and Trolox equivalent antioxidant capacity (TEAC). The CARTPT rs2239670 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) technique.ResultsThere was a significant interaction between CARTPT rs2239670 and dietary ORAC on BMI (Pinteraction = 0.048) and fat mass percent (FM%) (Pinteraction = 0.008); in A allele carriers, higher adherence to the dietary ORAC was related to lower level of BMI and FM%. As well as, the significant interactions were observed between FRAP index and rs2239670 in relation to HOMA (P interaction = 0.049) and QUICKI (P interaction = 0.048). Moreover, there were significant interactions of rs2239670 with TRAP (Pinteraction = 0.029) and TEAC (Pinteraction = 0.034) on the serum glucose level; individuals with AG genotype were more respondent to higher intake of TRAP.ConclusionThe present study indicated the interactions between CARTPT genotypes and dietary NEAC on obesity and its-related metabolic parameters. Further studies are warranted to confirm our findings.