bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of conventional and contrast-enhanced ultrasound diagnosis of fat-poor angiomyolipoma <5 cm
Authors: Liang Xia , Zeng Xian-Tao , Hong Zhi-Liang , Su Miao-Jiao , Yang Jian-Chuan , Wu Song-Song 
Published: December 2024

PurposeThis study aims to assess the diagnostic efficacy of conventional ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) in detecting fat-poor angiomyolipomas(AML) with dimensions less than 5 cm. Additionally, the study seeks to identify independent indicators for predicting the presence of fat-poor AML.MethodsWe conducted a retrospective analysis of patients diagnosed with renal AML and renal cell carcinoma, who were admitted and underwent surgery at Fujian Provincial Hospital from January 2013 to October 2023. A total of 154 renal tumors were included (104 renal cell carcinomas and 50 fat-poor AMLs). Prior to radical or partial nephrectomy, these patients underwent both CUS and CEUS examinations. We systematically analyzed the features observed in CUS and CEUS, identified independent factors through multifactorial regression analysis, and evaluated diagnostic efficacy by calculating the area under the curve (AUC).ResultsUnivariate analysis revealed significant distinctions in fat-poor AML concerning gender, age, morphology, internal hyperechoic features (starry-sky sign, crescent sign), enhancement uniformity, and delayed enhancement, all displaying significance compared to renal cell carcinoma (RCC) (p &lt; 0.05). Multivariate analysis demonstrated that internal hyperechoic features (p &lt; 0.01, Odds Ratio [OR] = 0.003, 95% Confidence Interval [CI]: 0.000-0.0028) and enhancement uniformity (p &lt; 0.01, OR = 0.016, 95% CI: 0.001-0.229) independently predicted fat-poor AML. The Receiver Operating Characteristic (ROC) curve’s area under the curve (AUC) for internal hyperechoic features (starry-sky sign, crescent sign) was 0.88 (95% CI: 0.80–0.95), with a sensitivity of 78.00%, specificity of 97.12%, positive predictive value of 92.85%, and negative predictive value of 90.18%. Conversely, the ROC curve AUC for enhancement uniformity was 0.70 (95% CI: 0.62–0.78), with a sensitivity of 96.00%, specificity of 44.23%, positive predictive value of 45.28%, and negative predictive value of 95.83%.ConclusionThis study suggests that both CUS and CEUS possess discriminative value in differentiating fat-poor AMLs from RCCs. Notably, internal hyperechoic features (starry-sky sign, crescent sign) and uniform enhancement within renal tumors emerge as potential independent indicators for predicting fat-poor AML.
Improved survival with second-line hepatic arterial infusion chemotherapy after atezolizumab-bevacizumab failure in hepatocellular carcinoma
Authors: Lee Ji Yeon , Lee Jaejun , Kim Suho , Yoo Jae-sung , Kim Ji Hoon , Yang Keungmo , Han Ji Won , Jang Jeong Won , Choi Jong Yong , Yoon Seung Kew , Chun Ho Jong , Oh Jung Suk , Sung Pil Soo 
Published: December 2024

BackgroundThere is no established second-line treatment for hepatocellular carcinoma (HCC) following atezolizumab-bevacizumab (ate-beva) failure. This study assessed the efficacy of hepatic arterial infusion chemotherapy (HAIC) as a salvage therapy by comparing survival outcomes and treatment responses between HAIC as a first-line treatment and as a second-line option after ate-beva failure.Materials and MethodsWe retrospectively analyzed 100 patients with advanced HCC treated with HAIC between March 2022 and July 2024. Patients were categorized into two groups: those who received HAIC as initial therapy (first-line HAIC group) and those who received HAIC following ate-beva failure (post-ate-beva group). Survival outcomes were assessed with Kaplan-Meier curves and log-rank tests, and factors associated with survival were identified through Cox regression analysis.ResultsThe post-ate-beva group exhibited longer overall survival (OS) (median OS 12.4 months) compared to the first-line HAIC group (median OS 6.8 months) (p = 0.073). Progression-free survival (PFS) was significantly superior in the post-ate-beva group (median PFS 8.2 months) compared to the first-line HAIC group (median PFS 3.1 months) (p = 0.018). The objective response rate was also notably higher in the post-ate-beva group than in the first-line HAIC group (35.3% vs. 18.1%, p = 0.031). In multivariate analysis, HAIC following ate-beva failure, compared to first-line HAIC, was significantly associated with favorable outcomes for both OS (p = 0.014) and PFS (p = 0.006).ConclusionThe superior survival outcomes and treatment responses observed in the post-ate-beva group suggest that HAIC may be an effective second-line treatment option for advanced HCC following ate-beva therapy failure. However, due to the retrospective nature and small sample size of the study, further prospective studies with larger patient populations are needed to strengthen the evidence.
Descriptive analysis of durvalumab use in unresectable stage III non-small cell lung cancer in patients treated in Quebec’s University teaching hospitals
Authors: Labrie Valérie , Lefebvre Judith , Labbé Catherine , Jao Kevin , Malick Mandy , Simard Serge , Bouchard Nicole 
Published: December 2024

IntroductionConsolidation durvalumab post chemo-radiotherapy (CRT) has been demonstrated to improve survival in locally advanced non-small-cell lung cancer (NSCLC). Real-world data to assess its use and impact on patients, particularly in Quebec, remain limited.MethodsWe, therefore, aimed to assess real-world durvalumab use in inoperable stage III NSCLC in Quebec, to describe progression-free survival (PFS) and overall survival (OS) outcomes as reported in the PACIFIC trial, and to evaluate safety and toxicity. Patients were retrospectively reviewed between January 1rst 2019 and December 31st 2020, based on their oncology reference date.ResultsOne hundred and eight patients treated with CRT were included, among which 82 received durvalumab (75.9%). The mean duration of treatment was 48 weeks [4-52], and 55% of patients completed the full treatment. Median PFS was 40 months in patients treated with CRT + durvalumab vs 6.9 months with CRT alone, with a hazard ratio (HR) of 0.22 (95% confidence interval (CI) 0.13-0.37; p &lt; 0.0001). Limited access to CT scanning during the COVID pandemic, might have led to delayed disease progression detection and thus prolonged PFS. Median OS was &gt; 52.8 months with CRT + durvalumab vs 19 months with CRT alone (HR 0.33, 95% CI 0.18-0.60; p=0.0002).DiscussionThese findings support the efficacy and safety profile of durvalumab in real-world settings.
Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes
Authors: Ban Tao , Dong Xianhui , Ma Ziyue , Jin Jing , Li Jing , Cui Yunfeng , Fu Yuyang , Wang Yongzhen , Xue Yadong , Tong Tingting , Zhang Kai , Han Yuxuan , Shen Meimei , Zhao Yu , Zhao Ling , Xiong Lingzhao , Lv Hongzhao , Liu Yang , Huo Rong 
Published: December 2024

BackgroundTransient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies demonstrated Brg1 impacted on cardiac sodium/potassium channels and electrophysiological stability, its influence on TRPM4 expression and function remained unexplored.MethodsWe investigated the role of Brg1 in regulating TRPM4 expression and function through overexpression and knockdown experiments in mouse cardiomyocytes and TRPM4-overexpressing HEK293 cells by western blot, qPCR, immunofluorescence staining and patch clamp techniques. Cardiomyocytes were exposed to hypoxia for 12 h to mimic cardiac stress, and Brg1 inhibition was performed to assess its impact on TRPM4 under hypoxia. Bioinformatic analyses (STRING and JASPAR databases), Co-immunoprecipitation (Co-IP), dual luciferase reporter assays, and Chromatin Immunoprecipitation (ChIP) were employed to study the interaction between Brg1, RUNX1, and TRPM4 transcription regulation.ResultsBrg1 positively regulated TRPM4 expression in mouse cardiomyocytes and modulated TRPM4 current in TRPM4-overexpressing HEK293 cells. Brg1 inhibition markedly diminishes TRPM4’s hyperexpression in cardiomyocytes exposed to hypoxia. Integrative analyses utilizing STRNG databases and Protein Data Bank unveiled a putative interaction between Brg1 and the transcription factor RUNX1, and we substantiated the interaction between Brg1 and RUNX1. Several binding sites of RUNX1 with the TRPM4 promoter region were predicted by the JASPAR database, and empirical validation substantiated Brg1 modulated TRPM4 promoter activity via RUNX1 engagement. ChIP confirmed that Brg1 interacted with RUNX1 forming a transcriptional complex that located in TRPM4 promoter.ConclusionOur study demonstrated that Brg1 and RUNX1 formed a transcriptional complex that modulated TRPM4 expression and function, especially under hypoxic conditions. These findings provided new insights into TRPM4 regulation and highlighted its potential as a therapeutic target for cardiac hypoxia-related disorders.
Psychological empowerment and challenge-oriented organizational citizenship behavior: a dual process model
Authors: Xu Qingquan , Liu Shan , Huang Haishen 
Published: December 2024

IntroductionEncouraging proactive behavior among employees is a crucial pathway for companies to adapt swiftly and gain a competitive edge. In contrast to other forms of organizational citizenship behavior that tend to preserve existing work practices within the organization, Challenge-Oriented Organizational Citizenship Behavior (COCB) aims to improve upon these by offering constructive suggestions and altering employees’ work methods, policies, and procedures for the benefit of the organization. However, not all employees are willing to engage in COCB, even when the organization actively encourages participation. Departing from traditional perspectives on workplace environments and leadership, we propose that psychological empowerment at the individual level may be a precursor to employees’ engagement in COCB.MethodsBased on social exchange theory, this study examines how employees’ psychological empowerment affects their challengeoriented organizational citizenship behavior (COCB), including the mediating roles of perceived insider status and affective commitment, as well as the moderating role of Chinese traditionality. Data was collected from 223 employees of manufacturing, IT, finance and service enterprises in Southern China using a multi-source and multi-wave survey.ResultsResults of the Structural Equation Modeling (SEM) show that psychological empowerment can positively affect COCB. Both perceived insider status and affective commitment act as mediators in the relationship between psychological empowerment and COCB. Moreover, Chinese traditionality has a moderating effect on the relationship between psychological empowerment and these mediators, and also the indirect effect of psychological empowerment on COCB. Specifically, the indirect effect was stronger when employees with lower levels of Chinese traditionality.DiscussionThis study provides a theoretical foundation for the individual-level antecedents of COCB, elucidating how the social exchange process between employees and the organization is transformed into COCB through psychological empowerment.
Promoting workplace psychological wellbeing through Yoga and Tai Chi classes in female university employees
Authors: Valdesalici Alice , Cerea Silvia , Pecunioso Alessandra , Paoli Antonio , Grigolin Gioia , Nardelli Rosa , Armenti Alessandra , Ghisi Marta 
Published: December 2024

IntroductionAcademic environments are known for their high demands, often resulting in significant distress among employees. Thus, identifying effective intervention strategies to mitigate workplace stress is essential. The present study aims to evaluate the potential benefits of mind–body interventions (i.e., Yoga and Tai Chi) on the psychological wellbeing and perceived mental and physical health of female university employees.MethodsA total of 166 female university employees and faculty members participated in 10 sessions of Tai Chi or Yoga. They completed self-report questionnaires assessing ruminative thoughts, somatic anxiety, general distress, perceived physical and mental health, and assertive and cooperative behaviors before and after the 10 Tai Chi/Yoga sessions. Additionally, participants completed a state anxiety questionnaire before and after Tai Chi/Yoga second and second-to-last lessons.ResultsResults showed significant differences between scores pre and post Tai Chi and Yoga programs, with lower ruminative thoughts (p = 0.007), lower somatic anxiety (p &lt; 0.001), and higher perceived mental health (p = 0.038) at the end of the programs (i.e., after 10 sessions) compared to the beginning. Moreover, significant differences were found in state anxiety scores, with a reduction in state anxiety at the end of the second (p &lt; 0.001) and second-to-last (p &lt; 0.001) lessons compared to the start.ConclusionOur findings highlight the potential positive impact of Tai Chi and Yoga programs on the psychological wellbeing and perceived mental health of female university employees. Immediate reductions in state anxiety following single sessions further underscore the potential of these practices for short-term stress relief. Overall, the results support the implementation of mind–body practices in workplace settings to promote a healthier work environment.
Evaluation of the quality of depression-related information on Chinese websites and video platforms: a cross-sectional comparative analysis
Authors: Chen YueDong , Yin Jia , Ding YuKe , Wang ChangYu , Zhu JiaXin , Niu Lu 
Published: December 2024

ObjectivesWe aimed to assess the quality of information regarding depression on Chinese websites and popular video platforms.MethodsWe conducted searches on website platforms (Baidu, Bing) and video platforms (Bilibili, Douyin) using search terms “depression”, “depressive disorder”, “depression treatment”, “depressive anxiety”, “depressed patient”, and “depressive symptoms”. We collected the first 50 results with each search term in each platform. Each website and video included in this study was assessed using The DISCERN instrument (DISCERN), Journal of American Medical Association benchmark criteria (JAMA), Hexagonal Radar Schema (HRS), and Global Quality Scores (GQS).ResultsA total of 177 websites, 216 Bilibili videos, and 244 Douyin videos were included. Among all the platforms, websites had the highest median scores on DISCERN and HRS, at 33 and 2 respectively, but were still classified as “poor” and “very poor” according to the classification. Bilibili, Douyin, and websites had median scores of 3, 2, and 2 respectively in JAMA, indicating a moderate level of quality. Bilibili, Douyin, and websites all had a median score of 2 for GQS, and were of poor quality. Only the percentage score for JAMA was more than half of the weighted score, while none of the other scales reached half of the score. The median percentage scores of the websites in DISCERN, HRS, and GQS were higher than those of Bilibili and Douyin (P &lt; 0.001). Compared to other sources, news media on websites and medical organizations on videos demonstrated higher quality (all P values &lt; 0.05).ConclusionsThe findings of the study indicated an overall low quality of online depression information. Collaborative efforts between platforms and professionals are necessary to improve the comprehensiveness and quality of depression-related information available online. In addition, the platform needs to prioritize optimizing the algorithm of recommendations and present real high-quality health information to the audience.
Effects of early-life environmental stress on risk-taking tendency of adolescents in rural areas of southwestern China
Authors: Wu Jing , Wu Qiaobing 
Published: December 2024

IntroductionAdolescence is a critical developmental phase characterized by increased risk-taking behaviors, which are not inherently maladaptive. According to life history theory, individuals raised in harsh and unpredictable environments are more likely to adopt faster life history strategies, favoring immediate rewards over long-term benefits. Yet, limited empirical research explore the psychological mechanism about how early-life environmental stresses influence adolescents’ risk-taking. In rural China, left-behind children face economic and social vulnerabilities due to parental migration to urban areas for employment. This study’s first goal was to identify the specific elements of early-life environmental stresses that impact adolescents’ risk-taking tendencies from a developmental evolutionary perspective. The second goal was to construct and test a synthesized model of how objective and subjective environmental stresses influence adolescents’ risk-taking.MethodsA total of 610 middle school students in rural China completed questionnaires assessing early-life environmental stresses and risk-taking tendencies. The sample included 318 left-behind adolescents, 120 single-left-behind adolescents with one parent, and 138 non-left-behind adolescents. Structural equation modeling tested the hypothesized model, examining direct and indirect effects of environmental stresses on risk-taking.ResultsObjective early-life environmental stresses, such as low socioeconomic status (SES), high mortality cues, and high mobility cues, predicted faster life history strategies, marked by shorter future orientation and increased risk-taking tendencies. Subjective perceptions of environmental unpredictability and parental warmth mediated the influence of SES on risk-taking. Biological sensitivity moderated mortality cues’ influence on perceived parental warmth. Sense of control failed to mediate the relationship between early-life stresses and risk-taking. Left-behind adolescents experienced more mobility and mortality cues, perceived greater unpredictability, and reported less parental warmth than their peers. Despite no significant difference in overall risk-taking, left-behind adolescents exhibited higher health/safety risk-taking tendencies.DiscussionThis study provides a comprehensive model linking early-life environmental stresses to adolescents’ risk-taking, integrating objective and subjective measures of stress. The findings offer insights into mechanisms driving risk-taking tendencies. Also, it have significant implications for developing interventions aimed at mitigating the adverse effects of early-life stress on adolescent development, particularly for left-behind children in rural China.
Purification and Electron Transfer from Soluble c-Type Cytochrome TorC to TorA for Trimethylamine N-Oxide Reduction
Authors: Panwar Alka , Martins Berta M. , Sommer Frederik , Schroda Michael , Dobbek Holger , Iobbi-Nivol Chantal , Jourlin-Castelli Cécile , Leimkühler Silke 
Published: December 2024

The enterobacterium Escherichia coli present in the human gut can reduce trimethylamine N-oxide (TMAO) to trimethylamine during anaerobic respiration. The TMAO reductase TorA is a monomeric, bis-molybdopterin guanine dinucleotide (bis-MGD) cofactor-containing enzyme that belongs to the dimethyl sulfoxide reductase family of molybdoenzymes. TorA is anchored to the membrane via TorC, a pentahemic c-type cytochrome which receives the electrons from the menaquinol pool. Here, we designed an expression system for the production of a stable soluble form of multiheme-containing TorC, providing, for the first time, the purification of a soluble pentahemic cytochrome-c from E. coli. Our focus was to investigate the interaction between TorA and soluble TorC to establish the electron transfer pathway. We solved the X-ray structure of E. coli TorA and performed chemical crosslinking of TorA and TorC. Another goal was to establish an activity assay that used the physiological electron transfer pathway instead of the commonly used unphysiological electron donors methylviologen or benzylviologen. An AlphaFold model including the crosslinking sites provided insights into the electron transfer between TorCC and the active site of TorA.
Caffeine-Induced Upregulation of pas-1 and pas-3 Enhances Intestinal Integrity by Reducing Vitellogenin in Aged Caenorhabditis elegans Model
Authors: Lee Mijin , Lee Jea , Kim Dongyeon , Min Hyemin , Shim Yhong-Hee 
Published: December 2024

Background: Intestinal aging is characterized by declining protein homeostasis via reduced proteasome activity, which are hallmarks of age-related diseases. Our previous study showed that caffeine intake improved intestinal integrity with age by reducing vitellogenin (VIT, yolk protein) in C. elegans. In this study, we investigated the regulatory mechanisms by which caffeine intake improves intestinal integrity and reduces vitellogenin (VIT) production in aged Caenorhabditis elegans. Methods: We performed RNA-seq analysis, and qRT-PCR to validate and confirm the RNA-seq results. Transgenic worms with VIT-2::GFP and VIT-6::GFP were used for measuring VIT production. dsRNAi was conducted to elucidate the roles of pas-1 and pas-3 genes. Results: pas-1 and pas-3, a C. elegans ortholog of human PASM4, was upregulated by caffeine intake. They reduced VIT production by repressing unc-62, a transcriptional activator of vit expression. Interestingly, vit-2 was required for pas-1 and pas-3 expression, and RNAi of pas-1 and pas-3 promoted intestinal atrophy and colonization, suggesting a balancing mechanism for VIT levels in intestinal health. Additionally, lifespan was extended by caffeine intake (2 ± 0.05 days), however, this effect was not observed by pas-1 but not pas-3 RNAi, suggesting that the mode of action for an anti-aging effect of caffeine through pas-1 and pas-3 is distinctive. The lifespan extended by pas-1 was mediated by SKN-1 activation. Conclusions: Caffeine intake enhances intestinal health through proteasome activity and extends lifespan in aged C. elegans by upregulating pas-1 and pas-3. These findings suggest that caffeine consumption mitigates age-related proteasome impairment and maintains intestinal integrity during aging.
Способ модификации хирургических инструментов для навигационной хирургии при дентальной имплантации. Клинический случай
Authors: Рачков А.А. , Рачков Р.А. 
Published: December 2024

Продемонстрирован способ модификации фрез и имплантоводов для оптимизации процесса хирургической подготовки кости и установки дентальных имплантатов. Цель. Провести клиническую оценку эффективности модифицированных фрез и имплантоводов для дентальной имплантации. Объекты и методы. Проведена модификация фрез и имплантоводов из набора для навигационной дентальной имплантации и оценена их клиническая эффективность.
A method for modifying cutters and implant drivers to optimize the process of surgical bone preparation and installation of dental implants is demonstrated. The purpose. To conduct a clinical evaluation of the effectiveness of modified milling cutters for dental implantation. Objects and methods. The cutters and implant drivers from the navigation dental implantation kit were modified and their clinical effectiveness was assessed.
Opposition à l’exécution d’une ordonnance d’injonction de payer : une valse à mille temps !
Authors: Vigouroux Naomi 
Published: December 2024

En vertu de la combinaison des articles 1411 et 1416 du Code de procédure civile, l’absence de signification à personne d’une ordonnance d’injonction de payer dans les six mois de sa date a pour seule conséquence de reporter l’ouverture du délai d’opposition dont dispose le débiteur et non de rendre l’ordonnance non avenue. Outre cet apport, il est important de rappeler la complexité des règles de la procédure d’injonction de payer surtout lorsqu’elles sont confrontées à l’application de la loi dans le temps.