bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pd NPs Decorated on POPs as Recyclable Catalysts for the Synthesis of 2‐Oxazolidinones from Propargylic Amines via Atmospheric Cyclizative CO2 Incorporation
Authors: Ghosh Swarbhanu , Riyajuddin Sk , Sarkar Somnath , Ghosh Kaushik , Islam Sk. Manirul 
Published: November 2019

AbstractA novel approach has been taken for the synthesis of a microporous polymeric materials of BBA‐1 and BBA‐2 (benzene−benzylamine), which is a POP (porous organic polymer) with its excellent surface area determined by BET study, via Friedel‐Crafts alkylation of benzene and benzylamine (or 4‐methoxybenzylamine) by utilizing a cross‐linker (formaldehyde dimethyl acetal) and a promoter (anhydrous FeCl3). Pd NPs were decorated over BBA‐1 and modified BBA‐2 to generate the desired catalysts (Pd@BBA‐1 and Pd@BBA‐2 respectively). The characterizations of the synthesized nanomaterials have been conducted by FE‐SEM, wide‐angle powder XRDmethods, N2 adsorption/desorption studies and high resolution transmission electron microscopy (TEM). Pd NPs decorated porous polymers are described here to facilitate the carboxylative cyclization of several propargylamine derivatives leading to the corresponding desired products (2‐oxazolidinone) under the application of ambient conditions (0.1 MPa of CO2, DMSO, 40–80 °C, 30–60 mg nanocatalyst). The Pd NPs‐loaded POP is competitive with previously reported catalytic systems. These pure polymeric microporous catalytic systems exhibited outstanding catalytic performances for the generation of oxazolidinones from several propargylic amines in the absence of organic and inorganic bases through atmospheric cyclizative CO2 incorporation. The modified nanocatalyst (Pd@BBA‐2) displayed exceptional recycling efficiency for the generation of oxazolidinones up to five runs without any noticeable decay in the activity of Pd@BBA‐2.
Luminescent Organogels Formed by Ionic Self‐Assembly of AIE‐Active Phospholes
Authors: Rabah Jad , Escola Antoine , Jeannin Olivier , Bouit Pierre‐Antoine , Hissler Muriel , Camerel Franck 
Published: November 2019

AbstractA straightforward synthesis of molecular gelators [1][CnBn] and [1][bisCnBn] (n=12, 16) based on ionic interactions between Aggregation‐Induced Emission (AIE)‐active anionic phosphole and functionalized imidazolium [CnBn] and [bisCnBn] is described. These new molecular gelators can form luminescent organogels in various solvents. The luminescent fibers were characterized by laser scanning confocal microscopy. Also, a 30‐fold increase in luminescence quantum yield was observed between the diluted solution (0.6 %) and the xerogel (20 %) of [1][C12Bn], thus highlighting the AIE effect. In these systems, the luminescence can be used to probe the dynamics of the aggregation upon solid‐state phase transition and gelation. Solid‐state investigations have also allowed the full characterization of the thermal behaviour of these ionic complexes and the extraction of some packing features.
Avian influenza virus prevalence in marine birds is dependent on ocean temperatures
Authors: Hall Jeffrey S. , Dusek Robert J. , Nashold Sean W. , TeSlaa Joshua L. , Allen R. Bradford , Grear Daniel A. 
Published: November 2019

AbstractWaterfowl and shorebirds are the primary hosts of influenza A virus (IAV), however, in most surveillance efforts, large populations of birds are not routinely examined; specifically marine ducks and other birds that reside predominately on or near the ocean. We conducted a long‐term study sampling sea ducks and gulls in coastal Maine for IAV and found a virus prevalence (1.7%) much lower than is typically found in freshwater duck populations. We found wide year‐to‐year variation in virus detection in sea ducks and that the ocean water temperature was an important factor affecting IAV prevalence. In particular, the ocean temperature that occurred 11 d prior to collecting virus positive samples was important while water temperature measured concurrently with host sampling had no explanatory power for viral detection. We also experimentally showed that IAV is relatively unstable in sea water at temperatures typically found during our sampling. This represents the first report of virus prevalence and actual environmental data that help explain the variation in marine IAV transmission dynamics.
Identification of phlebotomine sand flies (Diptera: Psychodidae) from leishmaniasis endemic areas in southeastern Mexico using DNA barcoding
Authors: Adeniran Adebiyi A. , Fernández‐Santos Nadia A. , Rodríguez‐Rojas Jorge J. , Treviño‐Garza Nancy , Huerta‐Jiménez Heron , Mis‐Ávila Pedro C. , Pérez‐Pech Wilbert A. , Hernández‐Triana Luis M. , Rodríguez‐Pérez Mario A. 
Published: November 2019

AbstractLeishmaniasis, a vector‐borne disease transmitted to humans through the bite of phlebotomine sand flies, is of public health significance in southeastern Mexico. Active and continuous monitoring of vectors is an important aspect of disease control for the prediction of potential outbreaks. Thus, the correct identification of vectors is paramount in this regard. In this study, we employed DNA barcoding as a tool for identifying phlebotomine sand flies collected in localized cutaneous leishmaniasis endemic areas of Quintana Roo, Mexico. Specimens were collected using CDC light and Shannon traps as part of the Mexican Ministry of Health surveillance program. DNA extraction was carried out using a nondestructive protocol, and morphological identification based on taxonomic keys was conducted on slide‐mounted specimens. Molecular taxonomic resolution using the 658‐bp fragment of the mitochondrial cytochromecoxidase subunit 1 (cox1) gene was 100% congruent with the morphological identification. Seven species were identified:Lutzomyia cruciata(Coquillett 1907),Lutzomyia longipalpis(Lutz & Neiva 1912),Psathyromyia shannoni(Dyar 1929),Dampfomyia deleoni(Fairchild & Hertig 1947),Dampfomyia beltrani/steatopyga(Vargas & Díaz‐Nájera 1951),Bichromomyia olmeca olmeca(Vargas & Díaz‐Nájera, 1959), andBrumptomyia mesai(Sherlock 1962). Mean intraspecific divergence ranged from 0.12% to 1.22%, while interspecific distances ranged from 11.59% to 19.29%. Neighbor‐joining (NJ) analysis using the Kimura 2‐parameter model also showed specimens of the same species to be clustered together. The study provides the firstcox1sequences for three species of sand flies and indicates the utility of DNA barcoding for phlebotomine sand flies species identification in southeastern Mexico.
Synthesis of Ni@NiSn Composite with High Lithium‐Ion Diffusion Coefficient for Fast‐Charging Lithium‐Ion Batteries
Authors: Zhao Hong , Chen Junxin , Wei Weiwei , Ke Shanming , Zeng Xierong , Chen Dongchu , Lin Peng 
Published: November 2019

AbstractTo solve the problems of fast‐charging of lithium‐ion batteries in essence, development of new electrode materials with higher lithium‐ion diffusion coefficients is the key. In this work, a novel flower‐like Ni@SnNi structure is synthesized via a two‐step process design, which consists of the fabrication of Ni cores by spray pyrolysis followed by the formation of SnNi shells via a simple oxidation–reduction reaction. The obtained Ni@SnNi composite exhibits an initial capacity of ≈693 mA h g−1 and a reversible capacity of ≈570 mA h g−1 after 300 charge/discharge cycles at 0.5 C, and maintains 450 mA h g−1 even at a high rate of 3 C. Further, it is proved that a Ni@SnNi composite possesses high lithium‐ion diffusion coefficient (≈10−8), which is much higher than those (≈10−10) reported previously, which can be mainly attributed to the unique flower‐like Ni@SnNi structure. In addition, the full cell performance (Ni@SnNi‐9h/graphite vs LiCoO2) with a capacity ratio of 1.13 (anode/cathode) is also tested. It is found that even at 2 C rate charging/discharging, the capacity retention at 100 cycles is still close to 89%. It means that Ni@SnNi‐9h is a promising anode additive for lithium‐ion batteries with high energy density and power density.
Clinical utility of 177Lu‐DOTATATE PRRT in somatostatin receptor‐positive metastatic medullary carcinoma of thyroid patients with assessment of efficacy, survival analysis, prognostic variables, and toxicity
Authors: Parghane Rahul V. , Naik Chinna , Talole Sanjay , Desmukh Anuja , Chaukar Devendra , Banerjee Sharmila , Basu Sandip 
Published: November 2019

AbstractBackgroundThe primary aim of this study was to evaluate the therapeutic efficacy and outcome of 177Lu‐DOTATATE peptide receptor radionuclide therapy (PRRT) in somatostatin receptor‐positive metastatic medullary thyroid carcinoma (MTC), including progression‐free survival (PFS) and overall survival (OS), and also to determine the various prognostic variables. The secondary aim was toxicity assessment of PRRT in this group of patients.MethodsA total of 43 somatostatin receptor‐positive metastatic MTC patients, treated with 177Lu‐DOTATATE PRRT in a large tertiary care center, were included in this analysis. After receiving the therapy, post‐treatment response evaluation was undertaken for symptomatic and biochemical responses (serum calcitonin) and imaging responses with 68Ga‐DOTATATE, 18F‐FDG PET‐CT, CeCT (PERCIST and RECIST 1.1 criteria). Calcitonin doubling time (CtnDT) was calculated by the American Thyroid Association calculator. The adverse events were graded according to the NCI‐CTCAE v5.0 criteria. The observed Kaplan‐Meier curves for both PFS and OS since first PRRT were compared with CtnDT (more than 24 months vs less than 24 months) by log‐rank (Mantel‐Cox) test. The prognostic variables were investigated for their association with CtnDT and response to PRRT using Cox proportional‐hazards model.RESULTSThe median OS was 26 months (95% CI 16.6‐35.3 months) and the median PFS 24 months (95%.CI: 15.1‐32.9 months). Following 177Lu‐DOTATATE PRRT, the observed median PFS and OS was longer in patients who had CtnDT more than 24 months compared to those with CtnDT less than 24 months (median PFS not yet reached vs 10 months and median OS 60 months vs 20 months). Assessing from the time‐point of first 177Lu‐DOTATATE PRRT cycle, the patients with CtnDT more than 24 months had a significantly longer PFS (P < .001) and OS (P < .001) compared to those with less than 24 months. Less than 5 lesions, FDG uptake in lesions (SUVmax of <5) and patients alive at the time of analysis were the significant variables for association with CtnDT (more than 24 months). Out of 43 patients, 26 were responders (61%) and 17 nonresponders (39%) based upon PERCIST criteria, and 27 were responders (62%) while 16 patients were nonresponders (38%) based upon RECIST 1.1 criteria. The univariate analysis showed significant association between responses to PRRT with following prognostic variables: (a) size of lesions (<2 cm) and (b) FDG uptake in lesions (SUVmax of <5). PRRT was well tolerated in all patients without any major grade 3 or 4 toxicity.ConclusionThe results demonstrated that, 177Lu‐DOTATATE is a potentially efficacious and safe therapeutic option in SSTR avid metastatic MTC patients.
Regime switches and permanent changes in impacts of housing risk factors on MSA‐level housing returns
Authors: Huang MeiChi 
Published: November 2019

AbstractThis study assesses impacts of housing risk factors on metropolitan housing excess returns in the augmented housing pricing model. Credit and liquidity factors represent demand and supply sides, respectively, of housing markets. All metropolitan statistical areas have significant regime switches, and booms and busts are turbulent and influenced by the two factors. The explanatory powers of the liquidity factor shrivel for the boom‐bust and regime‐switching volatility specifications, and excess housing returns are less sensitive to nationwide housing dynamics after 2008. This study lends support to time‐varying exposures of housing excess returns to risk factors in terms of temporary switches and permanent changes.
Synthesis, antiradical, and antimicrobial activities of new pteridine‐2,4,7‐trione derivatives
Authors: Kazunin Maksym S. , Voskoboynik Oleksii Yu. , Nosulenko Inna S. , Berest Galina G. , Kholodniak Sergiy V. , Pryymenko Boris O. , Kovalenko Sergiy I. 
Published: November 2019

AbstractThe synthesis of 6‐(2‐hydroxy‐2‐aryl (heteryl)ethyl)‐1‐methylpteridine‐2,4,7(1H,3H,8H)‐triones by the reduction of the corresponding ketones and the peculiarities of conversion of the synthesized alcohols to (E)‐1‐methyl‐6‐(2‐aryl (heteryl)ethenyl)pteridine‐2,4,7(1H,3H,8H)‐triones was reported. The mechanism of monomolecular elimination that occurred in the presence of hydrogen halides was discussed, namely, the competitive formation of an energy‐efficient conjugated system by deprotonation of a stable benzyl‐type carbocation. Alternative synthesis methods of pteridine‐2,4,7(1H,3H,8H)‐triones were developed. Abovementioned approach involved [4+2]‐cyclocondensation of 1‐methyl‐5,6‐diaminouracil to 2‐oxo‐4‐R‐but‐3‐enoic acids and Knoevenagel condensation of 1,6‐dimethylpteridine‐2,4,7(1H,3H,8H)‐trione with aromatic aldehydes. The antiradical, antimicrobial, and antifungal activities were studied for the synthesized compounds.
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism
Authors: Zhang Yang , Bobe Gerd , Revel Johana S. , Rodrigues Richard R. , Sharpton Thomas J. , Fantacone Mary L. , Raslan Kareem , Miranda Cristobal L. , Lowry Malcolm B. , Blakemore Paul R. , Morgun Andrey , Shulzhenko Natalia , Maier Claudia S. , Stevens Jan F. , Gombart Adrian F. 
Published: November 2019

ScopeTwo hydrogenated xanthohumol (XN) derivatives, α,β‐dihydro‐XN (DXN) and tetrahydro‐XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet‐induced obese murine model. It is hypothesized that improvements in obesity and MetS are linked to changes in composition of the gut microbiota, bile acid metabolism, intestinal barrier function, and inflammation.Methods and resultsTo test this hypothesis, 16S rRNA genes were sequenced and bile acids were measured in fecal samples from C57BL/6J mice fed a high‐fat diet (HFD) or HFD containing XN, DXN or TXN. Expression of genes associated with epithelial barrier function, inflammation, and bile acid metabolism were measured in the colon, white adipose tissue (WAT), and liver, respectively. Administration of XN derivatives decreases intestinal microbiota diversity and abundance—specifically Bacteroidetes and Tenericutes—alters bile acid metabolism, and reduces inflammation. In WAT, TXN supplementation decreases pro‐inflammatory gene expression by suppressing macrophage infiltration. Transkingdom network analysis connects changes in the microbiota to improvements in MetS in the host.ConclusionChanges in the gut microbiota and bile acid metabolism may explain, in part, the improvements in obesity and MetS associated with administration of XN and its derivatives.
A switchable dual‐mode fully‐differential common‐source low‐noise amplifier in 0.18‐μm CMOS technology
Authors: Zhang Changchun , Wang Yongkai , Gao Shenjun , Tang Lu , Zhang Yi , Park Sung Min 
Published: November 2019

AbstractA highly‐integrated switchable dual‐mode low‐noise amplifier (LNA) is proposed and implemented in standard 0.18 μm complementary metal‐oxide‐semiconductor (CMOS) technology for ultra‐high frequency‐radio‐frequency identification (UHF RFID) reader receivers. This dual‐mode LNA can be controlled to operate in two different modes in order to meet the requirements for the listen‐before‐talk mode and the normal mode of the UHF RFID reader receiver, respectively. The fully‐differential common‐source cascode topology with perfect input impedance matching, capacitive cross‐coupling, and common‐mode feedback techniques are employed to improve its performance. Measurement results show that, from a single power supply of 1.8 V, the LNA achieved the power gain (S21) of 9.1 dB, the input power reflection (S11) of −20 dB, the minimum noise figure (NF) of 3.6 dB, and the P1dB of −5 dBm in high‐gain mode. In high‐linearity mode, S21 of 3.2 dB, S11 of −17 dB, NF of 5.2 dB, and P1dB of −1.3 dBm were obtained.
The limited efficacy of 3D models for teaching students sex estimations based on cranial traits: A case for investment in osteology teaching labs
Authors: Kuzminsky Susan C. , Snyder Thomas J. , Tung Tiffiny A. 
Published: November 2019

AbstractThe use of 3D digital imaging methods has increased within biological anthropology and medical research. Although digital renderings can be easily shared by researchers or used for student learning modules in osteology, limitations to using 3D models exist, requiring institutions of higher learning to invest in real bones or casts of human skeletal remains for labs. Here, we examine whether 3D digital models are viable proxies for real bones by testing the reliability of scoring sexually dimorphic traits of the human skull, a method commonly used by North American skeletal biologists. Forty‐five crania from Peruvian archaeological sites were used to score four sexually dimorphic cranial traits. These morphological traits were scored by one student learning osteology and an experienced researcher using the actual crania and 3D models of the same individuals. Statistical tests of rater agreement and strength of the agreement were conducted.Results showed lower agreement between the actual and 3D scores for the student and higher agreement among the scores for the experienced researcher. Accurate and cost‐effective 3D models can serve as excellent replacements for real skeletal remains when researchers are experienced. However, 3D models may be a less reliable training tool for students learning osteological methods that require palpating areas of the human cranium. This study makes a strong case for purchasing quality casts or real human skeletal remains of legal/ethical origin for osteology teaching labs, despite their higher costs.
Study on stable detonation flame arrester test
Authors: Wang Peng , Bao Lei , Li Houda , Dang Wenyi , Yu Anfeng 
Published: November 2019

AbstractStable detonation flame arresters with nominal diameters from DN50 to DN300 were tested in accordance with the ISO 16852 standard, and the criteria for determining steady detonation were studied. According to the results of flame arrester tests, using the inner diameter of the pipeline as the basis for the pressure division yielded more accurate results, which was not clearly described in ISO 16852 standard. The target values of Pmd/PTB for the DN50 flame arrester were too small. Further studies are needed to determine appropriate ratios of Pmd/PTB for flame arresters with different pipe diameters. The run‐up distance required to form stable detonation was beyond L = 120 D, which is commonly believed to be the required distance for stable detonation to establish. Therefore, it is important to evaluate the conditions where flame arresters to be used and the conditions under which the flame arresters were tested.
Increasing clinical liquid chromatography/tandem mass spectrometry assay throughput using a full calibration curve generated by one injection from a single‐tube calibrator
Authors: Cournoyer Jason J. , Dey Subhakar 
Published: November 2019

RationaleMass spectrometry (MS) generally delivers more accurate results than immunoassay (IA) for certain clinically relevant analytes, but IA is still the more prevalent methodology used by clinical laboratories because of barriers to MS adoption, such as lower throughput. Therefore, it is increasingly important to develop new strategies to increase LC/MS/MS throughput so that more accurate results can be delivered to patients and clinicians.MethodsThroughput can be increased by reducing assay calibration time using a single‐tube calibrator, a mix of isotopologues of the target analyte at different concentrations in a biological matrix, rather than a set of traditional, multiple‐tube calibrators. One injection from a single‐tube calibrator can generate a full calibration curve such that each calibration point is from the multiple reaction monitoring (MRM) signal corresponding to a specific isotopologue.ResultsIn this study, a single‐tube calibrator (five levels in one vial) and a set of multiple‐tube calibrators (seven levels in seven vials) were used to measure the concentration of testosterone in 42 serum samples originally value assigned by the Centers for Disease Control and Prevention (CDC) reference method. The bias between the CDC reference method and the single‐tube calibrator measurements and the multiple‐tube calibrators measurements was +1.1% and − 5.5%, respectively. These results were within the CDC Hormone Standardization (HoSt) program bias acceptance criteria of ±6.4%.ConclusionsThe results show that LC/MS/MS throughput can be increased using a single‐tube calibrator because it reduces assay calibration time while delivering equivalent results to those generated using traditional, multiple‐tube calibrators. The single‐tube calibrator may also save cost to laboratories through reductions in consumable consumption, technician labor time, and inventory management, as well as to manufacturers because fewer vials would need to be manufactured, tested, stored, and shipped.
Self‐Assembly of DNA Origami Heterodimers in High Yields and Analysis of the Involved Mechanisms
Authors: Sheheade Breveruos , Liber Miran , Popov Mary , Berger Yaron , Khara Dinesh C. , Jopp Jürgen , Nir Eyal 
Published: November 2019

AbstractEfficient fabrication of structurally and functionally diverse nanomolecular devices and machines by organizing separately prepared DNA origami building blocks into a larger structure is limited by origami attachment yields. A general method that enables attachment of origami building blocks using ‘sticky ends' at very high yields is demonstrated. Two different rectangular origami monomers are purified using agarose gel electrophoresis conducted in solute containing 100 × 10−3 m NaCl, a treatment that facilitates the dissociation of most of the incorrectly hybridized origami structures that form through blunt‐end interactions during the thermal annealing process and removes these structures as well as excess strands that otherwise interfere with the desired heterodimerization reaction. Heterodimerization yields of gel‐purified monomers are between 98.6% and 99.6%, considerably higher than that of monomers purified using the polyethylene glycol (PEG) method (88.7–96.7%). Depending on the number of PEG purification rounds, these results correspond to about 4‐ to 25‐fold reduction in the number of incorrect structures observed by atomic force microscopy. Furthermore, the analyses of the incorrect structures observed before and after the heterodimerization reactions and comparison of the purification methods provide valuable information on the reaction mechanisms that interfere with heterodimerization.