bluuebunny/crossref_metadata_2025_split huggingface dataset:
Las TIC como apoyo al desarrollo de pensamiento creativo en la docencia de la arquitectura
Authors: Alba Dorado María Isabel , Muñoz González Carmen María , Joyanes Díaz María Dolores , Jiménez Morales Eduardo 
Published: December 2019

La presente comunicación tiene como objetivo difundir los resultados de un proyecto de innovación educativa desarrollado en la Escuela de Arquitectura de la Universidad de Málaga titulado “Las Tecnologías de la Información y la Comunicación (TIC) como apoyo al desarrollo y fomento de los procesos de pensamiento creativo en la docencia universitaria”. Este proyecto, en el que han participado profesores de varias áreas de conocimiento, ha profundizado en el aprovechamiento máximo de las oportunidades que estos recursos brindan no solo para la consecución de los objetivos pedagógicos, sino también para fomentar, estimular y desarrollar el pensamiento creativo, crítico e innovador. Los resultados obtenidos han puesto de manifiesto que la utilización de las TIC en la docencia de la arquitectura fomenta la creatividad en el alumnado y permite desarrollar un enfoque proactivo de la creatividad en el aula ejercitando competencias relacionadas con el pensamiento y el comportamiento creativo en los estudiantes.
The purpose of this paper is to disseminate the results of an educational innovation project developed at the School of Architecture of the University of Malaga entitled “Information and Communication Technologies (ICT) as support for the development and promotion of creative thinking processes in university teaching”. This project, in which professors from various areas of knowledge have participated, has deepened in the maximum use of the opportunities that these resources provide not only for the achievement of pedagogical objectives, but also to encourage, stimulate and develop creative thinking, Critical and innovative. The results have shown that the use of ICT in architecture teaching encourages creativity in students and allows the development of a proactive approach to creativity in the classroom by exercising skills related to creative thinking and creative behavior in students.
Exploring profile and potential influencers of vaginal microbiome among asymptomatic pregnant Chinese women
Authors: He Yining , Huang Yun , Zhang Zhengyin , Yu Fengping , Zheng Yingjie 
Published: December 2019

Background
This study was designed to explore the profile and potential influencers of the vaginal microbiome (VMB) among asymptomatic pregnant Chinese women and its possible association with pregnancy outcomes.

Methods
A prospective study was conducted among pregnant Chinese women receiving regular prenatal care at a hospital in Shanghai, China from March 2017 to March 2018. Vaginal swabs were obtained from 113 asymptomatic pregnant women in mid-pregnancy and sequenced by the V3–V4 region of 16S rRNA on an Ion S5™ XL platform. Demographic characteristics and major pregnancy outcomes were collected through questionnaires and electronic medical records.

Results
The predominant vaginal community state types (CSTs) were CST I (45.1%) and CST III (31.9%). Participants were divided into a lactobacilli-dominant group (LD, CST I/II/III/I–III/V, n = 100, 88.5%) and a less lactobacilli-dominant group (LLD, CST IV-A/B, n = 13, 11.5%). Women in the LLD group showed an increased alpha diversity [median (interquartile range, IQR): 2.41 (1.67, 2.49) vs. 0.30 (0.17, 0.59), P < 0.001], which was related to a lower pre-pregnancy body mass index (BMI) (P = 0.012), and a greater instance of passive smoking (P = 0.033). The relative abundance of Lactobacillus was correlated positively with the pre-pregnancy BMI (r = 0.177, P = 0.041), but negatively with passive smoking (r = − 0.204, P = 0.030).

Conclusion
The vaginal flora of asymptomatic pregnant Chinese women was mostly dominated by Lactobacillus crispatus and L. iners. A lower BMI and greater instance of passive smoking may contribute to a less lactobacilli-dominant VMB. However, a larger sample size is needed.
Retrospective clinical study of renin-angiotensin system blockers in lung cancer patients with hypertension
Authors: Wei Jie , Zhou Zhiyang , Xu Zhijie , Zeng Shuangshuang , Chen Xi , Wang Xiang , Liu Wanli , Liu Min , Gong Zhicheng , Yan Yuanliang 
Published: December 2019

Purpose
Renin-angiotensin system blockers (RASBs), which include angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-2 receptor 1 blockers (ARBs), have been reported to be associated with lung cancer metastasis, radiotherapy and chemotherapy. Until now, very limited clinical data for RASBs’ diagnostic and prognostic effects has existed for lung cancer chemotherapy in Chinese patients.

Methods
There were a total of 678 lung cancer patients with hypertension, of which 461 (68%) were in the non-RASBs group and 217 (32%) were in the RASBs group. Patients’ gender, age, smoking status, histologic differentiation, tumor size, pathological grade, lymph node metastasis, pathological stage and progression-free survival (PFS) were retrospectively analyzed between these two groups. The clinical effects of ACEIs and ARBs in lung cancer patients were compared via t tests, and χ2 test, and potential prognostic factors for progression-free survival (PFS) were evaluated by Kaplan–Meier analysis.

Results
Significant differences were observed in lymph node metastasis between the RASBs and non-RASBs groups. The RASBs group (62.8% vs 71.7%, p = 0.037) and ARBs group (60.0% vs 71.7%, p = 0.030) had lower lymph node metastasis, and patients with RASBs had a lower pathological stage than those in non-RASBs groups (67.1% vs 77.4%, p = 0.044 ). The PFS of the RASBs (10.7 vs. 6.7 months, p = 0.040) and ACEIs (12.9 vs 6.7 months, p = 0.021) groups were longer than that of the non-RASBs group, while no statistical difference was shown between the ACEIs and ARBs groups. Moreover, the significant results of PFS were further confirmed in pathological stage III–IV patients. In the non-RASB group, 55% of patients took calcium channel blockers (CCBs), and the ACEIs group have a significantly longer PFS compared to the non-CCBs group (6.4 vs 12.9 months, p = 0.036).

Conclusion
In this study, we showed that the use of RASBs is a positive factor for pathological stage and prognosis of lung cancer patients. Therefore, it is necessary to actively evaluate medical history, especially the use of anti-hypertension medication, in patients with lung cancer and reflect medical history in the treatment and management plans of these patients.
Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
Authors: Feng Fei , Li Yuanyuan , Huang Nanqu , Luo Yong 
Published: December 2019

Background
Icaritin (ICT) is a prenylflavonoid derivative from Epimedium brevicornum Maxim. ICT has been shown to have neuroprotective effects. We investigate how ICT affects secretion of amyloid precursor protein (APP).

Methods
We exposed APP-PS1-HEK293 cells to ICT to investigate its effect on beta-site amyloid cleaving enzyme (BACE)1. Cell viability was evaluated by MTT and lactate dehydrogenase (LDH) assays. The half-maximal inhibitory concentration (IC50) of ICT for BACE1 was measured using fluorescence resonance energy transfer. Effects of ICT on the mRNA expression of APP were assessed by quantitative polymerase chain reaction, and protein expression was measured by western blotting and immunofluorescence.

Results
Icaritin inhibited BACE1 activity and IC50 was 5.70 ± 1.09 μM. Compared with the control group, at ICT concentrations of 5 μM and 10 μM, the viability increased and LDH leakage decreased in APP-PS1-293 cells. Also, mRNA expression of A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) increased, while that of BACE1 and presenilin-1 (PS1) decreased, upon ICT treatment. Western blotting and immunofluorescence confirmed that protein expression of ADAM10, BACE1 and PS1 showed the same trend. Expression of the APP fragments sAPPβ and C-terminal fragment β decreased, while that of sAPPα increased, upon ICT treatment. Expression of amyloid β peptides in APP-PS1-HEK293 cells was lower in ICT-treated groups compared with that in the control group.

Conclusions
Icaritin, as a BACE1 inhibitor, inhibits APP secretion in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway.
Genetics of Gallstone Disease
Authors: Weber Susanne N. , Lammert Frank 
Published: December 2019

Abstract

Gallstone disease is one of the most frequent diseases, with up to 20% of adults developing gallstones and >20% of them symptoms. The treatment of symptomatic stones and their complications by endoscopy and surgery causes high costs in health care systems. Linkage studies in families and twins demonstrated that gallstones are, in part, genetically determined. Genome‐wide association studies have identified a panel of more than 30 ‘lithogenic genes’ that confer gallstone susceptibility in humans. The largest population attributable risk is conferred by variant p.D19H of the hepatobiliary and intestinal cholesterol transporter ABCG5/G8. Deficiency of a second hepatobiliary ABC transporter, the phosphatidylcholine translocase ABCB4, causes a peculiar type of gallstone disease and chronic cholangiopathy. Other lithogenic genes affect metabolic and inflammatory pathways along the gut–liver axis. Understanding the pathobiology of gallstones might help to overcome the current invasive treatment of gallstone disease by personalised effective prevention strategies for patients at risk.

Key Concepts

Gallstone disease is a complex disease affected by exogenous and genetic risk factors.

The hepatobiliary cholesterol transporter
ABCG5/G8
represents the major lithogenic gene in humans.

ABCB4 deficiency causes
low phospholipid‐associated cholelithiasis
(
LPAC
).

α
1
‐Antitrypsin (
SERPINA1
) and adiponutrin (
PNPLA3
) mutations do not only cause chronic liver diseases but modify gallstone disease.

In the future, polygenic risk scores for gallstone disease might guide prevention and non‐invasive treatment strategies.
Full‐Scale Osteochondral Regeneration by Sole Graft of Tissue‐Engineered Hyaline Cartilage without Co‐Engraftment of Subchondral Bone Substitute
Authors: Nie Xiaolei , Yang Jian , Chuah Yon Jin , Zhu Wenzhen , Peck Yvonne , He Pengfei , Wang Dong‐An 
Published: December 2019

AbstractIn this study, full‐scale osteochondral defects are hypothesized, which penetrate the articular cartilage layer and invade into subchondral bones, and can be fixed by sole graft of tissue‐engineered hyaline cartilage without co‐engraftment of any subchondral bone substitute. It is hypothesized that given a finely regenerated articular cartilage shielding on top, the restoration of subchondral bones can be fulfilled via spontaneous self‐remodeling in situ. Hence, the key challenge of osteochondral regeneration lies in restoration of the non‐self‐regenerative articular cartilage. Here, traumatic osteochondral lesions to be repaired in rabbit knee models are endeavored using novel tissue‐engineered hyaline‐like cartilage grafts that are produced by 3D cultured porcine chondrocytes in vitro. Comparative trials are conducted in animal models that are implanted with living hyaline cartilage grafts (LhCG) and decellularized LhCG (dLhCG). Sound osteochondral regeneration is gradually revealed from both LhCG and dLhCG‐implanted samples 50–100 d after implantation. Quality regeneration in both zones of articular cartilage and subchondral bones are validated by the restored osteochondral composition, structure, phenotype, and mechanical property, which validate the hypothesis of this study.
Improving the Curing and Mechanical Properties of Short Carbon Fibers/Epoxy Composites by Grafting Nano ZIF‐8 on Fibers
Authors: Zhan Yixing , Wang Yating , Wang Ming , Ding Xiaoqing , Wang Xinlong 
Published: December 2019

AbstractThe nano metal–organic framework particles (nano ZIF‐8) are grafted onto the surface of short carbon fibers (SCFs) by a facile in situ growth method in order to functionalize SCFs. The morphology, crystal structure, and chemical element composition of modified SCFs (ZIF‐8@SCFs) are investigated. The grafted nano‐ZIF‐8 could remarkably enhance the roughness, polarity, and wettability of SCFs surface and promote the curing reaction of epoxy composites. The tensile strength, flexural strength, elastic modulus, toughness, and impact strength of the epoxy composites with 1 wt% ZIF‐8@SCFs are increased by 25%, 31%, 51%, 28%, and 42% compared to that of the composites with 1 wt% SCFs, respectively. Furthermore, the storage modulus (E′) and glass transition temperature (Tg) are enhanced from 2558 MPa and 108.2 °C to 3000 MPa and 147.6 °C. The significant improvement in mechanical and thermomechanical properties of the prepared composites could be ascribed to the ameliorated wettability, enhanced mechanical interlock, and increased chemical bonding induced by ZIF‐8@SCFs.
Noble Metal Free, Visible Light Driven Photocatalysis Using TiO2 Nanotube Arrays Sensitized by P‐Doped C3N4 Quantum Dots
Authors: Kumar Pawan , Kar Piyush , Manuel Ajay P. , Zeng Sheng , Thakur Ujwal K. , Alam Kazi M. , Zhang Yun , Kisslinger Ryan , Cui Kai , Bernard Guy M. , Michaelis Vladimir K. , Shankar Karthik 
Published: December 2019

AbstractBulk g‐C3N4 is an earth‐abundant, easily synthesizable, and exceptionally stable photocatalyst with an electronic bandgap of 2.7 eV. Herein, the concepts of P‐doping and size quantization are combined to synthesize highly fluorescent P‐doped carbon nitride quantum dots (CNPQDs) with a bandgap of 2.1 eV. CNPQDs are hosted on anatase‐phase and rutile‐phase TiO2 nanotube array scaffolds, and examined as photoanodes for sunlight‐driven water‐splitting and as photocatalysts for surface catalytic reactions. Square‐shaped rutile phase TiO2 nanotube arrays (STNAs) decorated with CNPQDs (CNPQD‐STNA) generate 2.54 mA cm−2 photocurrent under AM1.5 G simulated sunlight. A champion hydrogen evolution rate of 22 µmol h−1 corresponds to a Faradaic efficiency of 93.2%. In conjunction with Ag nanoparticles (NPs), the CNPQD‐STNA hybrid is also found to be an excellent plexcitonic photocatalyst for the visible light‐driven transformation of 4‐nitrobenzenethiol (4‐NBT) to dimercaptoazobenzene (DMAB), producing reaction completion at a laser power of 1 mW (532 nm) while Ag NP/TNA and Ag NP/STNA photocatalysts cannot complete this transformation even at 10 mW laser power. The results point the way forward for photochemically robust, noble metal free, visible light harvesting photoacatalysts based on nanostructured heterojunctions of graphenic frameworks with TiO2.
Synthesis of 2,2,2‐Trifluoroethyl Oxazoles, Oxazolines and Furans via Alkyne Oxytrifluoromethylation
Authors: Dong Jia‐Jia , Zhang Song‐Lin 
Published: December 2019

AbstractThis study reports an oxytrifluoromethylation method for construction of oxazoles and furans motif and the concurrent incorporation of a 2,2,2‐trifluoroethyl group at the aromatic C5‐position. High‐valent copper(III) trifluoromethyl compounds are crucial to this reaction that induces oxy‐trifluoromethylation of alkynes with a pendant amide/enol group functioning as the oxygen‐nucleophile. A wide substrate scope is demonstrated with high efficiency and with broad functional group tolerance. Late‐stage functionalization of dehydrocholic acid, a complex drug compound, is accomplished to show the potential of this method for practical drug design.magnified image
Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity
Authors: Polo Ellen Christine , Wang Martí Fernández , Angnes Ricardo Almir , Braga Ataualpa A. C. , Correia Carlos Roque Duarte 
Published: December 2019

AbstractHerein we report the enantioselective Heck‐Matsuda arylation of acyclic E and Z‐alkenyl aryl ethers. The reactions were carried out under mild conditions affording the enantioenriched benzyl ethers in a regioselective manner, moderate to good yields (up to 73%), and in good to excellent enantiomeric ratios (up to 97:3). The enantioselective Heck‐Matsuda arylation has shown a broad scope (25 examples), and some key Heck‐Matsuda adducts were further converted into more complex and valuable scaffolds including their synthetic application in the synthesis of (R)‐Fluoxetine, (R)‐Atomoxetine, and in the synthesis of an enantioenriched benzo[c]chromene. Finally, in silico mechanistic investigations into the reaction's enantioselectivity were performed using density functional theory.magnified image
Rare‐Earth‐Metal‐Catalyzed Synthesis of Azaindolines and Naphthyridines via C−H Cyclization of Functionalized Pyridines
Authors: Ye Pengqing , Shao Yinlin , Zhang Fangjun , Zou Jinxuan , Ye Xuanzeng , Chen Jiuxi 
Published: December 2019

AbstractWe report herein a rare‐earth‐metal‐catalyzed insertion of a 2‐pyridine C(sp2)−H bond into an intramolecular unactivated vinyl bond. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodology is also used to construct other nitrogen‐containing compounds such as naphthyridine derivatives. A plausible mechanism for the formation of azaindolines involving initial C−H bond activation by the lanthanide complex followed by C=C insertion into a Ln−C bond to form an alkyl lanthanide species that subsequently undergoes cyclization is proposed.magnified image
Cobalt‐Free High‐Capacity Ni‐Rich Layered Li[Ni0.9Mn0.1]O2 Cathode
Authors: Aishova Assylzat , Park Geon‐Tae , Yoon Chong S. , Sun Yang‐Kook 
Published: December 2019

AbstractLi[Ni0.9Co0.1]O2 (NC90), Li[Ni0.9Co0.05Mn0.05]O2 (NCM90), and Li[Ni0.9Mn0.1]O2 (NM90) cathodes are synthesized for the development of a Co‐free high‐energy‐density cathode. NM90 maintains better cycling stability than the two Co‐containing cathodes, particularly under harsh cycling conditions (a discharge capacity of 236 mAh g−1 with a capacity retention of 88% when cycled at 4.4 V under 30 °C and 93% retention when cycled at 4.3 V under 60 °C after 100 cycles). The reason for the enhanced stability is mainly the ability of NM90 to absorb the strain associated with the abrupt anisotropic lattice contraction/extraction and to suppress the formation of microcracks, in addition to enhanced chemical stability from the increased presence of stable Mn4+. Although the absence of Co deteriorates the rate capability, this can be overcome as the rate capability of the NM90 approaches that of the NCM90 when cycled at 60 °C. The long‐term cycling stability of NM90 is confirmed in a full cell, demonstrating that it is one of the most promising Co‐free cathodes for high‐energy‐density applications. This study not only provides insight into redefining the role of Mn in a Ni‐rich cathode, it also represents a clear breakthrough in achieving a commercially viable Co‐free Ni‐rich layered cathode.
Hopper flows of mixtures of spherical and rod‐like particles via the multisphere method
Authors: Lattanzi Aaron M. , Stickel Jonathan J. 
Published: December 2019

AbstractThe discharge of granular media from hoppers plays a vital role in many solids handling operations. The dynamic flow of poly‐disperse nonspherical particles differs markedly from mono‐disperse spheres and highlights the need to rigorously account for particle shape effects. The multisphere discrete element method (MS‐DEM) was utilized here to examine the bulk packing fraction, discharge rate, collisional stress tensor, and order parameter of a bi‐disperse sphere‐rod mixture evacuating a hopper. A modified form of the Myers and Sellers correlation with variable shape factor is capable of replicating the MS‐DEM discharge data. The collisional stress tensor is observed to be highly symmetric for mono‐disperse spheres but becomes asymmetric when rod‐like particles are introduced. The order parameter within the hopper increases significantly during discharge and the rod‐like particles undergo shear induced alignment with their long dimensions orthogonal to the outflow plane.
Passive monitoring of phenological acoustic patterns reveals the sound of the camouflage grouper, Epinephelus polyphekadion
Authors: Jublier Noémie , Bertucci Frédéric , Kéver Loïc , Colleye Orphal , Ballesta Laurent , Nemeth Richard S. , Lecchini David , Rhodes Kevin L. , Parmentier Eric 
Published: December 2019

Abstract

Passive acoustic monitoring (PAM) is a non‐invasive technique that uses hydrophones to monitor populations and ecosystem dynamics. Although many applications of PAM have been developed in recent years, it has never been used to identify a calling marine species.
The south pass of Fakarava Atoll, French Polynesia, hosts spawning events of many reef fish species, including the camouflage grouper Epinephelus polyphekadion, with a spawning aggregation abundance exceeding 17 000 individuals during the full moons of June and July.
The current study aimed to use PAM to distinguish camouflage grouper sounds among the vocal activities of all fish recorded during the aggregation periods. Audio recordings analysis resulted in the identification of 29 sound types, some of which showed diel and lunar patterns.
Temporal analysis of these sounds in relation to spawning activities allowed the identification of camouflage grouper calls. These calls can be described as a single pulse or a series of ‘boom(s)’ with a pulse duration of ~44 ms and a low dominant frequency of 103 ± 31 Hz. Video recordings show that the camouflage grouper produces the ‘booms’ to initialize spawner ascent and to promote synchronous gamete release into the water column.
The study highlights for the first time that PAM can be used to identify the previously unknown sound of a fish species. Moreover, we can use it to understand the phenology of some biological activities for improving the resolution of fish biodiversity assessments.
Peptidylarginine Deiminase Autoimmunity and the Development of Anti–Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten–Carrier Model
Authors: Auger Isabelle , Balandraud Nathalie , Massy Emmanuel , Hemon Marie F. , Peen Elisa , Arnoux Fanny , Mariot Charlotte , Martin Marielle , Lafforgue Pierre , Busnel Jean‐Marc , Roudier Jean 
Published: December 2019

ObjectiveThe presence of autoantibodies to citrullinated proteins (ACPAs) often precedes the development of rheumatoid arthritis (RA). Citrullines are arginine residues that have been modified by peptidylarginine deiminases (PADs). PAD4 is the target of autoantibodies in RA. ACPAs could arise because PAD4 is recognized by T cells, which facilitate the production of autoantibodies to proteins bound by PAD4. We previously found evidence for this hapten–carrier model in mice. This study was undertaken to investigate whether there is evidence for this model in humans.MethodsWe analyzed antibody response to PAD4 and T cell proliferation in response to PAD4 in 41 RA patients and 36 controls. We tested binding of 65 PAD4 peptides to 5 HLA–DR alleles (DRB1*04:01, *04:02, *04:04, *01:01, and *07:01) and selected 11 PAD4 peptides for proliferation studies using samples from 22 RA patients and 27 controls. Peripheral blood lymphocytes from an additional 10 RA patients and 7 healthy controls were analyzed by flow cytometry for CD3, CD4, CD154, and tumor necrosis factor expression after PAD4 stimulation.ResultsOnly patients with RA had both antibodies and T cell responses to PAD4. T cell response to peptide 8, a PAD4 peptide, was associated with RA (P = 0.02), anti‐PAD4 antibodies (P = 0.057), and the shared epitope (P = 0.05).ConclusionACPA immunity is associated with antibodies to PAD4 and T cell responses to PAD4 and PAD4 peptides. These findings are consistent with a hapten–carrier model in which PAD4 is the carrier and citrullinated proteins are the haptens.