bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dose response relationship between accelerometer assessed daily steps and depressive symptoms in older adults: a two-year cohort study
Authors: Hsueh Ming-Chun , Stubbs Brendon , Lai Yun-Ju , Sun Chi-Kuang , Chen Li-Jung , Ku Po-Wen 
Published: July 2020

AbstractObjectivesthis study investigated the prospective associations of accelerometer assessed daily steps with subsequent depressive symptoms in older adults.Methodsa 2-year prospective study was performed in the community. A total of 285 older adults ≥65 years (mean age = 74.5) attended the baseline assessment in 2012. The second wave of assessment was carried out in 2014 including 274 (96.1%) participants. Daily step counts were measured with a triaxial accelerometer (ActiGraph GT3X+), and participants were divided into three categories (&lt;3,500, 3,500–6,999 and ≥ 7,000 steps/day). The 15-item Geriatric Depression Scale was used to measure depressive symptoms. Negative binomial regression models with multivariable adjustment for covariates (baseline depressive symptoms, accelerometer wear time, age, gender, education, chronic disease, activities of daily living) were conducted to examine the association between daily steps and subsequent depressive symptoms.Resultseach 1,000-step increase in daily walking was linearly associated with a reduced rate of subsequent depressive symptoms (rate ratio [RR] = 0.95, 95% confidence interval [CI] = 0.92–0.98). Participants with daily step count in 3,500–6,999 (RR = 0.84, 95% CI = 0.70–0.99) and ≥7,000 steps (RR = 0.71, 95% CI = 0.55–0.92) per day had fewer depressive symptoms at follow-up. Sensitivity analyses assessing confounding and reverse causation provided further support for the stability of our findings.Conclusionolder adults engaging in more daily steps had fewer depressive symptoms after 2 years. Even as few as 3,500–6,999 steps a day was associated with a protecting effect. Accumulating ≥7,000 steps a day could provide the greatest protection against depressive symptoms.
Social isolation and loneliness as related to progression and reversion of frailty in the Survey of Health Aging Retirement in Europe (SHARE)
Authors: Jarach Carlotta Micaela , Tettamanti Mauro , Nobili Alessandro , D'avanzo Barbara 
Published: July 2020

Abstract

Background
Frailty was shown to be associated with psychosocial risk factors, but there are few longitudinal data.

Methods
We used data from waves 5 and 6 of the Survey of Health Aging Retirement in Europe (SHARE) to study the contribution of loneliness and social isolation to transitions towards frailty defined according to Fried criteria in a sample of 27,468 individuals aged ≥60.

Results
At baseline, there were 13,069 (47.6%) robust individuals, 11,430 (41.6%) pre-frail and 2,969 (10.8%) frail. After 2 years, among robust subjects at baseline, 8,706 (61.8%) were still robust, 4,033 (30.8%) were pre-frail and 330 (2.6%) were frail. Among those who were pre-frail, 1,504 (13.2%) progressed to frail and 3,557 (31.1%) became robust. Among frail people, 182 (6.1%) reversed to robust and 1,271 (42.8%) to pre-frail. Average and high levels of loneliness and social isolation were significantly associated with the risk of robust people becoming frail and pre-frail (except robust with high loneliness to become frail), and of pre-frail people to become frail (except with average loneliness). Reversion to robustness was inversely associated with high levels of loneliness.

Conclusion
Average levels of loneliness and social isolation should not be considered acceptable and should be actively addressed even in the absence of any health conditions through an available evidence-based intervention.
Correlated evolution of leaf and root anatomic traits in Dendrobium (Orchidaceae)
Authors: Qi Ying , Huang Jia-Lin , Zhang Shi-Bao 
Published: July 2020

Abstract
The whole-plant economic spectrum concept predicts that leaf and root traits evolve in coordination to cope with environmental stresses. However, this hypothesis is difficult to test in many species because their leaves and roots are exposed to different environments, above- and below-ground. In epiphytes, both leaves and roots are exposed to the atmosphere. Thus, we suspect there are consistent water conservation strategies in leaf and root traits of epiphytes due to similar selection pressures. Here, we measured the functional traits of 21 species in the genus Dendrobium, which is one of the largest epiphytic taxa in the family Orchidaceae, and used phylogenetically independent contrasts to test the relationships among traits, and between traits and the environment. Our results demonstrate that species with a thicker velamen tended to have thicker roots, a thicker root cortex and vascular cylinder, and a larger number of vessels in the root. Correspondingly, these species also had higher leaf mass per area, and thicker leaf lower cuticles. Leaf and root traits associated with water conservation showed significantly positive relationships. The number of velamen layers, leaf density and the ratio of vascular cylinder radius to root radius were significantly affected by the species’ differing environments. Thus, traits related to water conservation and transport may play an important role in helping Dendrobium cope with the cool and dry conditions found at high elevations. These findings confirmed the hypothesis that leaf and root traits have evolved in coordination, and also provide insights into trait evolution and ecological adaptation in epiphytic orchids.
COVID-19 Docking Server: a meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19
Authors: Kong Ren , Yang Guangbo , Xue Rui , Liu Ming , Wang Feng , Hu Jianping , Guo Xiaoqiang , Chang Shan 
Published: July 2020

AbstractMotivationThe coronavirus disease 2019 (COVID-19) caused by a new type of coronavirus has been emerging from China and led to thousands of death globally since December 2019. Despite many groups have engaged in studying the newly emerged virus and searching for the treatment of COVID-19, the understanding of the COVID-19 target–ligand interactions represents a key challenge. Herein, we introduce COVID-19 Docking Server, a web server that predicts the binding modes between COVID-19 targets and the ligands including small molecules, peptides and antibodies.ResultsStructures of proteins involved in the virus life cycle were collected or constructed based on the homologs of coronavirus, and prepared ready for docking. The meta-platform provides a free and interactive tool for the prediction of COVID-19 target–ligand interactions and following drug discovery for COVID-19.Availability and implementationhttp://ncov.schanglab.org.cn.Supplementary informationSupplementary data are available at Bioinformatics online.
Strategy for improved characterization of human metabolic phenotypes using a COmbined Multi-block Principal components Analysis with Statistical Spectroscopy (COMPASS)
Authors: Loo Ruey Leng , Chan Queenie , Antti Henrik , Li Jia V , Ashrafian H , Elliott Paul , Stamler Jeremiah , Nicholson Jeremy K , Holmes Elaine , Wist Julien 
Published: July 2020

Abstract

Motivation
Large-scale population omics data can provide insight into associations between gene–environment interactions and disease. However, existing dimension reduction modelling techniques are often inefficient for extracting detailed information from these complex datasets.

Results
Here, we present an interactive software pipeline for exploratory analyses of population-based nuclear magnetic resonance spectral data using a COmbined Multi-block Principal components Analysis with Statistical Spectroscopy (COMPASS) within the R-library hastaLaVista framework. Principal component analysis models are generated for a sequential series of spectral regions (blocks) to provide more granular detail defining sub-populations within the dataset. Molecular identification of key differentiating signals is subsequently achieved by implementing Statistical TOtal Correlation SpectroscopY on the full spectral data to define feature patterns. Finally, the distributions of cross-correlation of the reference patterns across the spectral dataset are used to provide population statistics for identifying underlying features arising from drug intake, latent diseases and diet. The COMPASS method thus provides an efficient semi-automated approach for screening population datasets.

Availability and implementation
Source code is available at https://github.com/cheminfo/COMPASS.

Supplementary information
Supplementary data are available at Bioinformatics online.
Cholinergic muscarinic M1/M4 receptor networks in dementia with Lewy bodies
Authors: Colloby Sean J , Nathan Pradeep J , McKeith Ian G , Bakker Geor , O’Brien John T , Taylor John-Paul 
Published: July 2020

AbstractCholinergic dysfunction is central in dementia with Lewy bodies, possibly contributing to the cognitive and psychiatric phenotypes of this condition. We investigated baseline muscarinic M1/M4 receptor spatial covariance patterns in dementia with Lewy bodies and their association with changes in cognition and neuropsychiatric symptoms after 12 weeks of treatment with the cholinesterase inhibitor donepezil. Thirty-eight participants (14 cholinesterase inhibitor naive patients, 24 healthy older individuals) underwent 123I-iodo-quinuclidinyl-benzilate (M1/M4 receptor assessment) and 99mTc-exametazime (perfusion) single-photon emission computed tomography scanning. We implemented voxel principal components analysis, producing a series of images representing patterns of inter-correlated voxels across individuals. Linear regression analyses derived specific M1/M4 and perfusion spatial covariance patterns associated with patients. A discreet M1/M4 pattern that distinguished patients from controls (W1,19.7 = 16.7, P = 0.001), showed relative decreased binding in right lateral temporal and insula, as well as relative preserved/increased binding in frontal, precuneus, lingual and cuneal regions, implicating nodes within attention and dorsal visual networks. We then derived from patients an M1/M4 pattern that correlated with a positive change in mini-mental state examination (r = 0.52, P = 0.05), showing relative preserved/increased uptake in prefrontal, temporal pole and anterior cingulate, elements of attention-related networks. We also generated from patients an M1/M4 pattern that correlated with a positive change in neuropsychiatric inventory score (r = 0.77, P = 0.002), revealing relative preserved/increased uptake within a bilateral temporal-precuneal-striatal system. Although in a small sample and therefore tentative, we posit that optimal response of donepezil on cognitive and neuropsychiatric signs in patients with dementia with Lewy bodies were associated with a maintenance of muscarinic M1/M4 receptor expression within attentional/executive and ventral visual network hubs, respectively.
Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons
Authors: Enterría-Morales Daniel , del Rey Natalia López-González , Blesa Javier , López-López Ivette , Gallet Sarah , Prévot Vincent , López-Barneo José , d’Anglemont de Tassigny Xavier 
Published: July 2020

Abstract
Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has been tested in preclinical and clinical studies to evaluate its neuroprotective effects on the progressive dopaminergic neuronal degeneration that characterizes Parkinson’s disease. However, intracerebral glial cell line-derived neurotrophic factor infusion is a challenging therapeutic strategy, with numerous potential technical and medical limitations. Most of these limitations could be avoided if the production of endogenous glial cell line-derived neurotrophic factor could be increased. Glial cell line-derived neurotrophic factor is naturally produced in the striatum from where it exerts a trophic action on the nigrostriatal dopaminergic pathway. Most of striatal glial cell line-derived neurotrophic factor is synthesized by a subset of GABAergic interneurons characterized by the expression of parvalbumin. We sought to identify molecular targets specific to those neurons and which are putatively associated with glial cell line-derived neurotrophic factor synthesis. To this end, the transcriptomic differences between glial cell line-derived neurotrophic factor-positive parvalbumin neurons in the striatum and parvalbumin neurons located in the nearby cortex, which do not express glial cell line-derived neurotrophic factor, were analysed. Using mouse reporter models, we have defined the genomic signature of striatal parvalbumin interneurons obtained by fluorescence-activated cell sorting followed by microarray comparison. Short-listed genes were validated by additional histological and molecular analyses. These genes code for membrane receptors (Kit, Gpr83, Tacr1, Tacr3, Mc3r), cytosolic proteins (Pde3a, Crabp1, Rarres2, Moxd1) and a transcription factor (Lhx8). We also found the proto-oncogene cKit to be highly specific of parvalbumin interneurons in the non-human primate striatum, thus highlighting a conserved expression between species and suggesting that specific genes identified in mouse parvalbumin neurons could be putative targets in the human brain. Pharmacological stimulation of four G-protein-coupled receptors enriched in the striatal parvalbumin interneurons inhibited Gdnf expression presumably by decreasing cyclic adenosine monophosphate formation. Additional experiments with pharmacological modulators of adenylyl cyclase and protein kinase A indicated that this pathway is a relevant intracellular route to induce Gdnf gene activation. This preclinical study is an important step in the ongoing development of a specific pro-endo-glial cell line-derived neurotrophic factor pharmacological strategy to treat Parkinson’s disease.
Interhemispheric Relationship of Genetic Influence on Human Brain Connectivity
Authors: Zhong Suyu , Wei Long , Zhao Chenxi , Yang Liyuan , Di Zengru , Francks Clyde , Gong Gaolang 
Published: July 2020

Abstract
To understand the origins of interhemispheric differences and commonalities/coupling in human brain wiring, it is crucial to determine how homologous interregional connectivities of the left and right hemispheres are genetically determined and related. To address this, in the present study, we analyzed human twin and pedigree samples with high-quality diffusion magnetic resonance imaging tractography and estimated the heritability and genetic correlation of homologous left and right white matter (WM) connections. The results showed that the heritability of WM connectivity was similar and coupled between the 2 hemispheres and that the degree of overlap in genetic factors underlying homologous WM connectivity (i.e., interhemispheric genetic correlation) varied substantially across the human brain: from complete overlap to complete nonoverlap. Particularly, the heritability was significantly stronger and the chance of interhemispheric complete overlap in genetic factors was higher in subcortical WM connections than in cortical WM connections. In addition, the heritability and interhemispheric genetic correlations were stronger for long-range connections than for short-range connections. These findings highlight the determinants of the genetics underlying WM connectivity and its interhemispheric relationships, and provide insight into genetic basis of WM connectivity asymmetries in both healthy and disease states.
Genomic Prediction of Antimicrobial Resistance: Ready or Not, Here It Comes!
Authors: Ransom Eric M , Potter Robert F , Dantas Gautam , Burnham Carey-Ann D 
Published: July 2020

AbstractBackgroundNext-generation sequencing (NGS) technologies are being used to predict antimicrobial resistance. The field is evolving rapidly and transitioning out of the research setting into clinical use. Clinical laboratories are evaluating the accuracy and utility of genomic resistance prediction, including methods for NGS, downstream bioinformatic pipeline components, and the clinical settings in which this type of testing should be offered.ContentWe describe genomic sequencing as it pertains to predicting antimicrobial resistance in clinical isolates and samples. We elaborate on current methodologies and workflows to perform this testing and summarize the current state of genomic resistance prediction in clinical settings. To highlight this aspect, we include 3 medically relevant microorganism exemplars: Mycobacterium tuberculosis, Staphylococcus aureus, and Neisseria gonorrhoeae. Last, we discuss the future of genomic-based resistance detection in clinical microbiology laboratories.SummaryAntimicrobial resistance prediction by genomic approaches is in its infancy for routine patient care. Genomic approaches have already added value to the current diagnostic testing landscape in specific circumstances and will play an increasingly important role in diagnostic microbiology. Future advancements will shorten turnaround time, reduce costs, and improve our analysis and interpretation of clinically actionable results.
Prevalence and concordant occurrence of esophageal, gastric, duodenal, and colonic eosinophilia
Authors: Sonnenberg Amnon , Turner Kevin O , Singhal Anuradha , Genta Robert M 
Published: July 2020

Summary
Eosinophilic esophagitis, gastritis, duodenitis, and colitis are rare diseases. Few studies have been able to accumulate sufficiently large number of patients to analyze their clinical epidemiology. The aim of the present epidemiologic study was to examine the prevalence and concordant occurrence of gastrointestinal (GI) eosinophilia. Using a database of histopathologic records, a cross-sectional study among 302,061 patients undergoing bidirectional endoscopy evaluated the concordant occurrence of esophageal, gastric, duodenal, and colonic eosinophilia. The prevalence rates (PRs) of GI eosinophilia were expressed per 1,000 study subjects with their 95% Poisson confidence intervals (CIs). The concordant occurrence of various forms of GI eosinophilia was compared to their overall occurrence in the study population by calculating odds ratios (ORs) and their 95% CI. The database contained 3,008 patients with esophageal eosinophilia (PR = 9.96, 9.61–10.32), 366 patients with gastric eosinophilia (1.21, 1.09–1.34), 10 patients with duodenal eosinophilia (0.03, 0.02–0.06), and 124 patients with colonic eosinophilia (0.41, 0.34–0.49). The occurrence of esophageal eosinophilia was associated with an increased occurrence of gastric eosinophilia (OR = 3.58, 2.06–6.23), duodenal (40.22, 12.61–128.31), and colonic eosinophilia (8.12, 4.26–15.49). Similarly, we also found statistically significant associations between gastric eosinophilia and duodenal or colonic eosinophilia, and between duodenal and colonic eosinophilia. In the adult, as in the pediatric population, patients with any type of GI eosinophilia are at an increased risk for simultaneously harboring eosinophilia at multiple sites of their GI tract. With the exception of esophageal eosinophilia, however, other forms of GI eosinophilia are rarely diagnosed.
Performance of Seed Treatments Applied on Bt and Non-Bt Maize Against Fall Armyworm (Lepidoptera: Noctuidae)
Authors: Muraro Dionei S , Stacke Regis F , Cossa Gisele E , Godoy Daniela N , Garlet Cínthia G , Valmorbida Ivair , O’Neal Matthew E , Bernardi Oderlei 
Published: July 2020

AbstractFall armyworm (FAW), Spodoptera frugiperda (J. E. Smith), is the main pest of maize in Brazil, attacking plants from emergence to reproductive stages. Here, we conducted studies to evaluate the efficacy of two seed treatments (chlorantraniliprole alone and imidacloprid combined with thiodicarb) on Bt and non-Bt maize in laboratory bioassays with distinct FAW strains that are susceptible, selected for resistance to Bt-maize single (Cry1F) or pyramided (Cry1A.105 + Cry2Ab2) events and F1 hybrids of the selected and susceptible strains (heterozygotes), and in the field against a natural infestation. In the laboratory, leaf-discs from seed treated Bt-maize plants at 7 d after emergence (DAE) increased the mortality of FAW resistant, heterozygote, and susceptible strains up to 24.8%, when compared with the respective maize grown without a seed treatment. In the field against natural infestations of FAW, Bt maize with a seed treatment had ~30% less FAW damage than non-Bt maize with the same seed treatment at 7 and 14 DAE. No differences in FAW damage was observed between Bt and non-Bt maize grown with and without a seed treatment at 21 DAE. Maize seeds treated with chlorantraniliprole alone or imidacloprid and thiodicarb combined presented limited protection against early infestations of FAW strains under laboratory and field studies.
Education, Birth Order and Family Size
Authors: Bagger Jesper , Birchenall Javier A , Mansour Hani , Urzúa Sergio 
Published: July 2020

Abstract
This article introduces a framework to study parental investments in the presence of birth order preferences and/or human capital cost differentials across children. The framework yields canonical models as special cases and delivers sharp testable predictions concerning how parental investments respond to an exogenous change in family size in the presence of birth order effects. These predictions characterize a generalised quantity–quality trade-off. Danish administrative data confirm our theory’s predictions. We find that for any given parity, the human capital profile of children in smaller families dominates that of large families, and that the average child’s education decreases as family size increases, even after taking birth order effects into consideration.
Atrial fibrillation and atrial tachycardia in patients with chronic thromboembolic pulmonary hypertension treated with pulmonary endarterectomy
Authors: Havranek Stepan , Fingrova Zdenka , Ambroz David , Jansa Pavel , Kuchar Jan , Dusik Milan , Lindner Jaroslav , Kunstyr Jan , Aschermann Michael , Linhart Ales 
Published: July 2020

Abstract
Atrial fibrillation (AF) and atrial tachycardia (AT) are frequently observed in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who were treated with pulmonary endarterectomy (PEA). Their prevalence and impact on prognosis of patients are not known. We analysed the prevalence of AF/AT and the clinical outcome in 197 patients with CTEPH treated with PEA (median age 62; interquartile range 53–68 years; 62% males). The prevalence of AF/AT was 29% (57 patients). Compared to patients without arrhythmia, the subjects with AF/AT were older [60 (50–67) vs. 62 (57–70) years], manifested an increased size of the left atrium [39 (35–44) vs. 45 (40–50) mm], had a reduced 6-min walking distance [411 (321–506) vs. 340 (254–460) m], and higher pulmonary artery systolic pressure after PEA [38 (30–47) vs. 45 (38–71) mmHg], all results with P-value &lt;0.05. During the follow-up with a median 4.2 (1.6–6.3) years, 45 (23%) patients died. In a multivariate Cox regression model only the male gender [hazard ratio (HR) 2.27, 95% confidence interval (CI) 1.15–4.50], a reduced 6-min walking distance (HR 3.67, 95% CI 1.74–7.73), and an increased New York Heart Association class (HR 8.56, 95% CI 4.17–17.60) were associated with mortality (P &lt; 0.05). The prevalence of AF/AT in patients with CTEPH treated with PEA is high. Arrhythmias are associated with reduced functional capacity but not with mortality.