bluuebunny/crossref_metadata_2025_split huggingface dataset:
Une prose gourmande et savoureuse ?
Authors: Eyries Alexandre 
Published: July 2020

Dans cet article, je me propose d’analyser une frange singulière de l’œuvre de l’écrivain américain Jim Harrison (1937-2016) mais ô combien centrale dans sa trajectoire d’auteur et surtout d’homme et de bon vivant à l’appétit vorace pour la bonne chère, les meilleurs vins et les plaisirs bien terrestres (amour des femmes, passion pour la nature et les grands espaces, la chasse et la pêche) qui jalonnent toute son œuvre, des romans aux poèmes ainsi qu’aux novellas ces longues nouvelles comme Légendes d’automne qui lui ont valu la célébrité sur la scène littéraire internationale. Dans le présent article, je m’intéresserai tout particulièrement à l’expérience gastronomique et œnologique telle qu’elle est mise en scène et en récit dans l’ouvrage Un sacré gueuleton. Manger, boire et vivre (Flammarion, 2018) qui rassemble la totalité des articles écrits par Jim Harrison tout au long de sa vie sur l’expérience gastronomique et œnologique à laquelle l’écrivain a très largement donné son corps dans des agapes infinies au cours desquelles « la règle de base est d’être “modéré à l’excès” » (p. 40).Dans l’introduction qu’il a rédigé pour cet ouvrage, le chef cuisinier new yorkais Mario Batali dresse le portrait suivant de Jim Harrison : « Jim avait un appétit légendaire et rien ne rend un cuisinier plus heureux que quelqu’un qui ne vit que pour manger – et, quand il ne mange pas, pour parler de ce qu’il a mangé, pour chasser et pêcher des choses à manger ou pour passer du temps, entre deux repas, à évoquer ce que nous venions de manger » (p. 9). L’ouvrage Un sacré gueuleton. Manger, boire et vivre – à la démesure de son auteur, cousin américain de Rabelais et manière d’épigone d’Hemingway – est un véritable festin littéraire. Il constitue à la fois une envolée discursive et littéraire et des moments propices à l’élaboration d’une prose gourmande et savoureuse par ses trouvailles stylistiques comme par ses excès et son outrance toute gargantuesque. Dans la première partie de cet article, j’analyserai les discours incarnés et éminemment littéraires tenus par l’auteur sur le vin et sa dégustation, sur la dimension anthropologique de ce phénomène sous-tendant les pratiques de convivialité et de commensalité. Dans la seconde partie de l’article, je m’attacherais aux écrits de l’auteur sur la gastronomie à l’aune de logiques de caractérisation, de recommandation et d’expertise acquises au cours d’une longue existence de gourmand vagabond ayant sillonné tous les terroirs de France et du monde.
Variation in contents of active components and antibacterial activity in different parts of Lonicera japonica Thunb
Authors: Yan Luyun , Xie Yulei , Wang Youyou , Zhu Jinhua , Li Mingjing , Liu Xiuhua , Zhao Dongbao 
Published: July 2020

Abstract

Background

Lonicera japonica Thunb has been comprehensively used as a traditional Chinese medicine which contains a variety of medicinally active substances.

Objectives
The active constituents in various parts of L. japonica Thunb (leaves [LE], flowers fl, and green buds [GB]) were studied to rational and efficient use of this medicinal plant.

Methods
UV–vis spectrophotometry was used for the determination of the total flavonoids; gas chromatography–mass spectrometric method was employed for the analysis of volatile components; and high-performance liquid chromatography technology was applied to detect nine bioactive components including chlorogenic acid, neochlorogenic acid, isochlorogenic acid C, caffeic acid, luteolin, galuteolin, hyperoside, rutin, and quercetin in different parts of L. japonica Thunb. The antimicrobial effects of LE, FL, and GB were further measured using agar plate drilling method.

Results
The content of the total flavonoids in different portions of L. japonica Thunb has significant difference, and the content with the decreasing sequence is found in GB, LE, and FL. The contents of main volatile components were highest in FL, followed by GB and LE. Besides, the contents of galuteolin, luteolin, rutin, and isochlorogenic acid C were higher in LE than those in FL and GB, and neochlorogenic acid content was similar in LE and FL. The antimicrobial effects showed that LE had the best inhibitory activity on Staphylococcus aureus (SA) and extended spectrum β-lactamases SA.

Conclusions
The research in this study provided valuable evidences for the reasonable and efficient utilization of L. japonica Thunb.
Detection of brain metastases using alternative magnetic resonance imaging sequences: a comparison between SPACE and VIBE sequences
Authors: Kongpromsuk Sutasinee , Pitakvej Nantaporn , Jittapiromsak Nutchawan , Prakkamakul Supada 
Published: July 2020

Abstract

Background
Accurate identification of brain metastases is crucial for cancer treatment.

Objectives
To compare the ability to detect brain metastases of two alternative types of contrast-enhanced three-dimensional (3D) T1-weighted sequences called SPACE (Sampling Perfection with Application optimized Contrasts using different flip angle Evolutions) and VIBE (Volumetric Interpolated Brain Sequence) on magnetic resonance imaging (MRI) at 3 tesla.

Methods
Between April 2017 and February 2018, 27 consecutive adult Thai patients with a total number of 424 brain metastases were retrospectively included. The patients underwent both contrast-enhanced 3D T1-weighted SPACE and 3D T1-weighted VIBE MRI sequences at 3 tesla. Two neuroradiology experts independently reviewed the images to determine the number of enhancing lesions on each sequence. Wilcoxon signed rank test was used to compare the difference between the numbers of detectable parenchymal enhancing lesions. Interobserver reliability was calculated using intraclass correlation.

Results
3D T1-weighted SPACE detected more parenchymal enhancing lesions than 3D T1-weighted VIBE (424 vs. 378 lesions, median 6 vs. 5, P = 0.008). Fifteen patients (55.6%) had equal number of parenchymal enhancing lesions between two sequences. 3D T1-weighted SPACE detected more parenchymal enhancing lesions (up to 9 more lesions) in 10 patients (37%), while 3D T1-weighted VIBE detected more enhancing lesions (up to 2 more lesions) in 2 patients (7.4%). Interobserver reliability between the readers was excellent.

Conclusion
Contrast-enhanced 3D T1-weighted SPACE sequence demonstrates a higher ability to detect brain metastases than contrast-enhanced 3D T1-weighted VIBE sequence at 3 tesla.
A simple model to detect atrial fibrillation via visual imaging
Authors: Corino Valentina D. A. , Iozzia Luca , Scarpini Giorgio , Mainardi Luca T. , Lombardi Federico 
Published: July 2020

AbstractAutomatic detection of atrial fibrillation (AF) is a challenging issue. In this study we proposed and validated a model to identify AF by using facial video recordings. We analyzed photoplethysmographic imaging (PPGi) signals, extracted from video of a subject’s face. Sixty-eight patients were included: 30 in sinus rhythm (SR), 25 in AF and 13 presenting with atrial flutter or frequent ectopic beats (ARR). Twenty-six indexes were computed. The dataset was divided in three subsets: the training, validation, and test set, containing, respectively, 58, 29, and 13% of the data. Mean of inter-systolic interval series (M), Local Maxima Similarity (LMS), and pulse harmonic strength (PHS) indexes were significantly different among all groups. Variability and irregularity parameters had the lowest values in SR, the highest in AF, with intermediate values in ARR. The PHS was higher in SR than in ARR, and higher in ARR than in AF. The LMS index was the highest in SR, intermediate in ARR and the lowest in AF. Similarity indexes were higher in SR than in AF and ARR. A model with three features, namely M, Similarity1 and LMS was chosen. With this model, the accuracy for the validation set was 0.947±0.007 for SR, 0.954±0.004 for AF and 0.919±0.006 for ARR; for the test set (never-seen data), accuracy was 0.876±0.021 for SR, 0.870±0.030 for AF and 0.863±0.029 for ARR. A contactless video-based monitoring can be used to detect AF, differentiating it from SR and from frequent ectopies.
Analysis of livestock breeders’ perceptions and their adaptation measures to climate change in Morocco‘s arid rangelands
Authors: Snaibi Wadii 
Published: July 2020

AbstractThe high plateaus of eastern Morocco are already suffering from the adverse impacts of climate change (CC), as the local populations’ livelihoods depend mainly on extensive sheep farming and therefore on natural resources. This research identifies breeders’ perceptions about CC, examines whether they correspond to the recorded climate data and analyses endogenous adaptation practices taking into account the agroecological characteristics of the studied sites and the difference between breeders’ categories based on the size of owned sheep herd. Data on perceptions and adaptation were analyzed using the Chi-square independence and Kruskal-Wallis tests. Climate data were investigated through Mann-Kendall, Pettitt and Buishand tests.Herders’ perceptions are in line with the climate analysis in term of nature and direction of observed climate variations (downward trend in rainfall and upward in temperature). In addition, there is a significant difference in the adoption frequency of adaptive strategies between the studied agroecological sub-zones (χ2 = 14.525, p <.05) due to their contrasting biophysical and socioeconomic conditions, as well as among breeders’ categories (χ2 = 10.568, p < .05) which attributed mainly to the size of sheep flock. Policy options aimed to enhance local-level adaptation should formulate site-specific adaptation programs and prioritise the small-scale herders.
Solving biharmonic problems on irregular domains by stably evaluated Gaussian kernel
Authors: Krowiak Artur 
Published: July 2020

Abstract
The paper extends recently developed idea of stable evaluation of the Gaussian kernel. Owing to this, the Gaussian radial basis function that is sensitive to the shape parameter can be stably evaluated and applied to interpolation problems as well as to solve differential equations, giving highly accurate results. But it can be done only with grids being the Cartesian product of sets of points, what limits the use of this idea to rectangular domains. In the present paper, by the association of an appropriate transformation with the mentioned method, the latter is applied to solve biharmonic problems on quadrilateral irregular domains. As an example, in the present work this approach is applied to solve bending as well as free vibration problem of thin plates. In the paper some strategies for the implementation of the boundary conditions are also presented and examined due to the accuracy. The numerical tests show high accuracy and usefulness of the method.
Estimation of permeability and saturation based on imaginary component of complex resistivity spectra: A laboratory study
Authors: Jia Jiang , Ke Shizhen , Li Junjian , Kang Zhengming , Ma Xuerui , Li Manman , Guo Jieyi 
Published: July 2020

Abstract
Low-frequency resistivity logging plays an important role in the field of petroleum exploration, but the complex resistivity spectrum of rock also contains a large amount of information about reservoir parameters. The complex resistivity spectra of 15 natural sandstone cores from western China, with different water saturations, were measured with an impedance analyzer. The pore space of each core was saturated with NaCl solution, and measurements were collected at a frequency range of 40–15 MHz. The results showed a linear relationship between the real resistivity at 1 kHz and the maximum values of imaginary resistivity for each core with different water saturations. The slopes of the linear best-fit lines had good linear relationships with the porosity and the permeability of cores. Based on this, a permeability estimation model was proposed and tested. In addition, the maxima of imaginary resistivity had power exponential relationships with the porosity and the water saturation of the cores. A saturation evaluation model based on the maxima of imaginary resistivity was established by imitating Archie’s formula. The new models were found to be feasible for determining the permeability and saturation of sandstone based on complex resistivity spectrum measurements. These models advance the application of complex resistivity spectrum in petrophysics.
A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -
Authors: Oettel Michael , Zentel Hans Joachim , Nickisch Klaus 
Published: July 2020

Abstract
The different etiopathogenetic mechanisms and the diversity of clinical features of endometriosis has not yet allowed to identify a causal pharmacological monotherapy satisfying the unresolved medical needs in this important female disease. Therefore, despite the search for new therapeutic principles for the indication, the strategy of gradual optimization of established therapeutic principles should not be disregarded.
In the case of progestins, the fact that each compound has its own, specific profile may allow to study the therapeutic relevance of the various signal cascades influenced by their receptors.
Using the example of the progestin dienogest, the different genomic and non-genomic mechanisms of action are discussed. It is pharmacodynamic profile is unique compared to other progestins.
In light of the emerging multitude of pathomechanisms in endometriosis, a monotherapy may not be possible, and then the search for broad spectrum compounds or combination therapies with dual or multiple mode of action in a clinically relevant dose range might be considered. The progestogenic action may greatly benefit from, by way of example, additional anti-inflammatory and/or anti-fibrotic and/or pro-apoptotic activities. Such a strategy could lead to new drug classes.
The link between dynamic hyperinflation, autonomic dysfunction and exercise testing parameters with masked heart failure in patients with non-severe obstructive pulmonary disease
Authors: Cherneva Radostina Vl. , Denchev Stefan Veselinov , Cherneva Zheina Vl. 
Published: July 2020

Abstract

Objectives
Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease (COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF.

Methods
We applied CPET in 68 subjects. Echocardiography was performed before CPET and 1–2 min after peak exercise. IC manoeuvres were applied. Patients were divided into two groups: patients with and without masked HFpEF. Wilkoff method calculated the meatabolic – chronotropic relationship (MCR). Chronotropic incompetence (CI) and abnormal HR recovery (HRR) were determined.

Results
The prevalence of CI was 77 vs. 52% in patients with/without masked HFpEF; of abnormal HRR – 98 vs. 62% respectively; of DH – 53 vs. 29%. ICdyn was associated with AD. Univariate regression showed association between masked HFpEF, ICdyn, HRR, oxygenuptake (’VO2), ’VO2 at anaerobic threshold, oxygen (O2) pulse and ’VE/’VCO2 slope. None of these parameters is an independent predictor for masked HFpEF.

Conclusions
DH, AD, and masked HFpEF are prevalent in non-severe COPD patients, who complain of exertional dyspnea and are free of clinically overt CV comorbidities. DH is independently associated with AD. Neither AD, nor DH and CPET are independent predictors for masked HFpEF.
Autoimmune hyperthyroidism in children & adolescents in Sudan: a 13 years’ experience of a Paediatric Endocrinology Clinic
Authors: Fadlalbari Ghassan Faisal , Mukhwana Renson O. , Abdullah Mohamed Ahmed 
Published: July 2020

Abstract

Background
Little has been published about hyperthyroidism in children from Sudan or Africa. In limited resource countries, lack of facilities and sociocultural factors might make international diagnosis and management guidelines difficult to follow. We aimed to determine the magnitude of autoimmune hyperthyroidism, clinical presentation, diagnosis, management and its outcome in Sudan.

Method
Records of all patients diagnosed as Graves’ disease (GD) or Hashitoxicosis (HTx) were reviewed and missing data filled by interviewing patients and/or their families. Data including age, sex, clinical presentation, investigations, management and outcome were obtained.

Results
Eighty-eight patients, 80 with GD (F:M = 4.7:1) and 8 with HTx (F:M = 7:1), were diagnosed at 11.8 ± 3.05 and 11.23 ± 2.78 years, respectively (p = 0.52). GD patients were diagnosed based on presence of exophthalmos (66.25%), positive thyroid receptor autoantibodies (12.5%), prolonged illness duration (8.75%) or remission failure to only B blocker (16.25%). All GD patients were started on carbimazole and cumulative remission rate was 11.8%, 32.4% and 41.2% by end of the second, third and fourth year respectively, however it plateaus after that. While 12 GD patients underwent surgery, only three opted for radioiodine ablation.

Conclusion
Hyperthyroidism is not an uncommon problem. In absence of laboratory facilities, differentiation between GD and HTx can be made based on clinical grounds. Continuation of medical treatment for 4 years can increase the remission rate to 41.2%. In Sudan, surgery is the preferred method of definitive therapy.
GCK-MODY in a child with cystic fibrosis: the doubt of the treatment plan
Authors: Salzano Giuseppina , Passanisi Stefano , Lucanto Maria Cristina , Costa Stefano , Pajno Giovanni Battista , Lombardo Fortunato 
Published: July 2020

Abstract

Objectives
The diagnosis of cystic fibrosis related diabetes (CFRD) is not often easy as glucose homeostasis may be influenced by various disease-related conditions such as enteral continuous drip feeding, frequent acute illness, use of systemic corticosteroids and other concomitant medications. Other forms of diabetes should be considered in the diagnostic work-up, particularly in the first decade of life.

Case presentation
We hereby present the case of a cystic fibrosis 6-year-old female child diagnosed with glucokinase-maturity onset of diabetes of the young (GCK-MODY). The choice of treatment plan was doubtful since GCK-MODY does not usually require insulin treatment, but hyperglycemia could pose a threat to the respiratory tract. After intensive glucose monitoring, we decided to defer pharmacological treatment based on acceptable daily glycemic control. To date, no worsening in her respiratory function has been revealed.

Conclusions
Recognition of non-CFRD forms of diabetes is fundamental to plan the most suitable treatment and follow-up.
Transition metal catalyzed site-selective cysteine diversification of proteins
Authors: Jbara Muhammad 
Published: July 2020

Abstract
Site-specific protein conjugation is a critical step in the generation of unique protein analogs for a range of basic research and therapeutic developments. Protein transformations must target a precise residue in the presence of a plethora of functional groups to obtain a well-characterized homogeneous product. Competing reactive residues on natural proteins render rapid and selective conjugation a challenging task. Organometallic reagents have recently emerged as a powerful strategy to achieve site-specific labeling of a diverse set of biopolymers, due to advances in water-soluble ligand design, high reaction rate, and selectivity. The thiophilic nature of various transition metals, especially soft metals, makes cysteine an ideal target for these reagents. The distinctive reactivity and selectivity of organometallic-based reactions, along with the unique reactivity and abundancy of cysteine within the human proteome, provide a powerful platform to modify native proteins in aqueous media. These reactions often provide the modified proteins with a stable linkage made from irreversible cross-coupling steps. Additionally, transition metal reagents have recently been applied for the decaging of cysteine residues in the context of chemical protein synthesis. Orthogonal cysteine protecting groups and functional tags are often necessary for the synthesis of challenging proteins, and organometallic reagents are powerful tools for selective, rapid, and water-compatible removal of those moieties. This review examines transition metal-based reactions of cysteine residues for the synthesis and modification of natural peptides and proteins.
Removal of bacterial growth inhibition of anticancer drugs by using complexation materials
Authors: Sangnier Maïté , Bouguéon Guillaume , Berroneau Aude , Dubois Véronique , Crauste-Manciet Sylvie 
Published: July 2020

AbstractIn the context of batch production of cytotoxic drugs in hospital pharmacies with the need of sterility testing, the objective was to validate the use of Rapid Microbiological Method (RMM), and to develop adequate neutralization method in case of inhibition of bacterial growth. The potential microbiological growth inhibitory effect of three anticancer drugs (5 fluorouracil, irinotecan and oxaliplatin) selected for batch production was assessed on BacT/ALERT® system. Among cytotoxic drugs, only 5FU exhibited inhibitory effect on microbiological growth using rapid microbiological method. To counteract this effect our purpose was to use neutralizing agents complexing the drug i. e. activated carbon or ion exchange resins. The microbiological bactericidal concentration of 5FU was very low (1.10–4 mg/mL) indicating the absolute need to neutralize the whole drug before sterility test. The complexation was validated by High Performance Liquid Chromatography control of the residual 5FU concentration in solution after the use of neutralizing agents. Only activated carbon was able to fully capture 5FU when previously diluted at 5 mg/mL. Conversely, the resins, in the condition of the study, were not able to fully capture 5FU whatever the dilution. The microbiological growth on BacT/ALERT® system after active carbon treatment was successfully confirmed with Staphylococcus aureus. Based on this validation results a method was then developed to routinely be able to perform sterility test of the batches produced and was confirmed on five microbiological species (i. e. S. aureus, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Aspergillus brasiliensis). Our work gives a new insight for considering sterility testing by rapid microbiological method even for drugs exhibiting inhibitory effect on microbiological growth.