bluuebunny/crossref_metadata_2025_split huggingface dataset:
Music predictability and liking enhance pupil dilation and promote motor learning in non-musicians
Authors: Bianco R. , Gold B. P. , Johnson A. P. , Penhune V. B. 
Published: November 2019

AbstractHumans can anticipate music and derive pleasure from it. Expectations facilitate the learning of movements associated with anticipated events, and they are also linked with reward, which may further facilitate learning of the anticipated rewarding events. The present study investigates the synergistic effects of predictability and hedonic responses to music on arousal and motor-learning in a naïve population. Novel melodies were manipulated in their overall predictability (predictable/unpredictable) as objectively defined by a model of music expectation, and ranked as high/medium/low liked based on participants’ self-reports collected during an initial listening session. During this session, we also recorded ocular pupil size as an implicit measure of listeners’ arousal. During the following motor task, participants learned to play target notes of the melodies on a keyboard (notes were of similar motor and musical complexity across melodies). Pupil dilation was greater for liked melodies, particularly when predictable. Motor performance was facilitated in predictable rather than unpredictable melodies, but liked melodies were learned even in the unpredictable condition. Low-liked melodies also showed learning but mostly in participants with higher scores of task perceived competence. Taken together, these results highlight the effects of stimuli predictability on learning, which can be however overshadowed by the effects of stimulus liking or task-related intrinsic motivation.
Modes of the antibiotic activity of amphotericin B against Candida albicans
Authors: Grela Ewa , Zdybicka-Barabas Agnieszka , Pawlikowska-Pawlega Bozena , Cytrynska Malgorzata , Wlodarczyk Monika , Grudzinski Wojciech , Luchowski Rafal , Gruszecki Wieslaw I. 
Published: November 2019

AbstractAmphotericin B is an antibiotic used as the “gold standard” in the treatment of life-threatening fungal infections. Several molecular mechanisms have been proposed to explain exceptionally high effectiveness of amphotericin B in combating fungi. In the present work, we apply fluorescence lifetime imaging microscopy to track, step by step, modes of the toxic activity of amphotericin B towards a clinical strain of Candida albicans. The images recorded reveal that the antibiotic binds to cells in the form of the small aggregates characterized by a relatively short fluorescence lifetime (0.2 ns). Amphotericin B binds preferentially to the cell walls of mature cells but also to the plasma membranes of the daughter cells at the budding stage. The images recorded with the application of a scanning electron microscopy show that the antibiotic interferes with the formation of functional cell walls of such young cells. The results of imaging reveal the formation of the amphotericin B-rich extramembranous structures and also binding of the drug molecules into the cell membranes and penetration into the cells. These two modes of action of amphotericin B are observed in the time scale of minutes.
Locomotion and eating behavior changes in Yucatan minipigs after unilateral radio-induced ablation of the caudate nucleus
Authors: Coquery Nicolas , Adam Jean-François , Nemoz Christian , Janvier Régis , Livingstone Jayde , Chauvin Alain , Kefs Samy , Guerineau Cécile , De Saint Jean Loic , Ocadiz Alexandre , Bouchet Audrey , Bartzsch Stefan , Schültke Elisabeth , Siegbahn Albert , Bräuer-Krisch Elke , Lemasson Benjamin , Barbier Emmanuel Luc , Laissue Jean , Balosso Jacques , Val-Laillet David , Serduc Raphael 
Published: November 2019

AbstractThe functional roles of the Caudate nucleus (Cd) are well known. Selective Cd lesions can be found in neurological disorders. However, little is known about the dynamics of the behavioral changes during progressive Cd ablation. Current stereotactic radiosurgery technologies allow the progressive ablation of a brain region with limited adverse effects in surrounding normal tissues. This could be of high interest for the study of the modified behavioral functions in relation with the degree of impairment of the brain structures. Using hypofractionated stereotactic radiotherapy combined with synchrotron microbeam radiation, we investigated, during one year after irradiation, the effects of unilateral radio-ablation of the right Cd on the behavior of Yucatan minipigs. The right Cd was irradiated to a minimal dose of 35.5 Gy delivered in three fractions. MRI-based morphological brain integrity and behavioral functions,i.e. locomotion, motivation/hedonism were assessed. We detected a progressive radio-necrosis leading to a quasi-total ablation one year after irradiation, with an additional alteration of surrounding areas. Transitory changes in the motivation/hedonism were firstly detected, then on locomotion, suggesting the influence of different compensatory mechanisms depending on the functions related to Cd and possibly some surrounding areas. We concluded that early behavioral changes related to eating functions are relevant markers for the early detection of ongoing lesions occurring in Cd-related neurological disorders.
Aluminosilicate Nanocomposite on Genosensor: A Prospective Voltammetry Platform for Epidermal Growth Factor Receptor Mutant Analysis in Non-small Cell Lung Cancer
Authors: Ramanathan Santheraleka , Gopinath Subash C. B. , Arshad M. K. Md , Poopalan Prabakaran , Anbu Periasamy , Lakshmipriya Thangavel , Kasim Farizul Hafiz 
Published: November 2019

AbstractLung cancer is one of the most serious threats to human where 85% of lethal death caused by non-small cell lung cancer (NSCLC) induced by epidermal growth factor receptor (EGFR) mutation. The present research focuses in the development of efficient and effortless EGFR mutant detection strategy through high-performance and sensitive genosensor. The current amplified through 250 µm sized fingers between 100 µm aluminium electrodes indicates the voltammetry signal generated by means of the mutant DNA sequence hybridization. To enhance the DNA immobilization and hybridization, ∼25 nm sized aluminosilicate nanocomposite synthesized from the disposed joss fly ash was deposited on the gaps between aluminium electrodes. The probe, mutant (complementary), and wild (single-base pair mismatch) targets were designed precisely from the genomic sequences denote the detection of EGFR mutation. Fourier-transform Infrared Spectroscopy analysis was performed at every step of surface functionalization evidences the relevant chemical bonding of biomolecules on the genosensor as duplex DNA with peak response at 1150 cm−1 to 1650 cm−1. Genosensor depicts a sensitive EGFR mutation as it is able to detect apparently at 100 aM mutant against 1 µM DNA probe. The insignificant voltammetry signal generated with wild type strand emphasizes the specificity of genosensor in the detection of single base pair mismatch. The inefficiency of genosensor in detecting EGFR mutation in the absence of aluminosilicate nanocomposite implies the insensitivity of genosensing DNA hybridization and accentuates the significance of aluminosilicate. Based on the slope of the calibration curve, the attained sensitivity of aluminosilicate modified genosensor was 3.02E-4 A M−1. The detection limit of genosensor computed based on 3σ calculation, relative to the change of current proportional to the logarithm of mutant concentration is at 100 aM.
Extracellular Membrane Vesicles from Lactobacilli Dampen IFN-γ Responses in a Monocyte-Dependent Manner
Authors: Mata Forsberg Manuel , Björkander Sophia , Pang Yanhong , Lundqvist Ludwig , Ndi Mama , Ott Martin , Escribá Irene Buesa , Jaeger Marie-Charlotte , Roos Stefan , Sverremark-Ekström Eva 
Published: November 2019

AbstractSecreted factors derived from Lactobacillus are able to dampen pro-inflammatory cytokine responses. Still, the nature of these components and the underlying mechanisms remain elusive. Here, we aimed to identify the components and the mechanism involved in the Lactobacillus-mediated modulation of immune cell activation. PBMC were stimulated in the presence of the cell free supernatants (CFS) of cultured Lactobacillus rhamnosus GG and Lactobacillus reuteri DSM 17938, followed by evaluation of cytokine responses. We show that lactobacilli-CFS effectively dampen induced IFN-γ and IL-17A responses from T- and NK cells in a monocyte dependent manner by a soluble factor. A proteomic array analysis highlighted Lactobacillus-induced IL-1 receptor antagonist (ra) as a potential candidate responsible for the IFN-γ dampening activity. Indeed, addition of recombinant IL-1ra to stimulated PBMC resulted in reduced IFN-γ production. Further characterization of the lactobacilli-CFS revealed the presence of extracellular membrane vesicles with a similar immune regulatory activity to that observed with the lactobacilli-CFS. In conclusion, we have shown that lactobacilli produce extracellular MVs, which are able to dampen pro-inflammatory cytokine responses in a monocyte-dependent manner.
Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
Authors: Vacher Michael , Porter Tenielle , Villemagne Victor L. , Milicic Lidija , Peretti Madeline , Fowler Christopher , Martins Ralph , Rainey-Smith Stephanie , Ames David , Masters Colin L. , Rowe Christopher C. , Doecke James D. , Laws Simon M. 
Published: November 2019

AbstractThe accumulation of brain amyloid β (Aβ) is one of the main pathological hallmarks of Alzheimer’s disease (AD). However, the role of brain amyloid deposition in the development of AD and the genetic variants associated with this process remain unclear. In this study, we sought to identify associations between Aβ deposition and an a priori evidence based set of 1610 genetic markers, genotyped from 505 unrelated individuals (258 Aβ+ and 247 Aβ−) enrolled in the Australian Imaging, Biomarker & Lifestyle (AIBL) study. We found statistically significant associations for 6 markers located within intronic regions of 6 genes, including AC103796.1-BDNF, PPP3R1, NGFR, KL, ABCA7 & CALHM1. Although functional studies are required to elucidate the role of these genes in the accumulation of Aβ and their potential implication in AD pathophysiology, our findings are consistent with results obtained in previous GWAS efforts.
A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants
Authors: Ticha Ivana , Hojny Jan , Michalkova Romana , Kodet Ondrej , Krkavcova Eva , Hajkova Nikola , Nemejcova Kristyna , Bartu Michaela , Jaksa Radek , Dura Miroslav , Kanwal Madiha , Martinikova Andra S. , Macurek Libor , Zemankova Petra , Kleibl Zdenek , Dundr Pavel 
Published: November 2019

AbstractThe most common histological subtypes of cutaneous melanoma include superficial spreading and nodular melanoma. However, the spectrum of somatic mutations developed in those lesions and all potential druggable targets have not yet been fully elucidated. We present the results of a sequence capture NGS analysis of 114 primary nodular and superficial spreading melanomas identifying driver mutations using biostatistical, immunohistochemical and/or functional approach. The spectrum and frequency of pathogenic or likely pathogenic variants were identified across 54 evaluated genes, including 59 novel mutations, and the newly identified TP53 loss-of-function mutations p.(L194P) and p.(R280K). Frequently mutated genes most commonly affected the MAPK pathway, followed by chromatin remodeling, and cell cycle regulation. Frequent aberrations were also detected in the genes coding for proteins involved in DNA repair and the regulation and modification of cellular tight junctions. Furthermore, relatively frequent mutations were described in KDR and MET, which represent potential clinically important targets. Those results suggest that with the development of new therapeutic possibilities, not only BRAF testing, but complex molecular testing of cutaneous melanoma may become an integral part of the decision process concerning the treatment of patients with melanoma.
Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort
Authors: Browne Declan , Williams Michael A. , Maxwell Alexander P. , McGuinness Bernadette , Passmore Peter , Silvestri Giuliana , Woodside Jayne V. , McKay Gareth J. 
Published: November 2019

AbstractProgressive renal decline is associated with increasing oxidative stress. However, the majority of studies have investigated endogenous antioxidants in predominantly advanced stages of kidney disease. Many traditional risk factors associated with renal dysfunction have been linked with cognitive decline as the kidneys and brain share comparable anatomic and haemodynamic characteristics that leave them susceptible to common pathogenic mechanisms. The objective of this study was to examine serum dietary antioxidants and their association with renal function characterised by estimated glomerular filtration rate (eGFR) in a cross-sectional analysis of 570 participants. High performance liquid chromatography quantified serum levels of retinol, α-tocopherol, γ-tocopherol and six carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene and zeaxanthin) in participants. Multiple regression analyses were used to evaluate associations while adjusting for potential confounders. A sensitivity analysis was performed in cognitively-intact participants only. Serum levels of the xanthophyll carotenoid lutein were positively associated with eGFR in analyses adjusted for age (years), gender, smoking, APOE4 status and Alzheimer’s disease. Retinol was inversely associated with eGFR, although was no longer significant in the smaller sensitivity analysis. Our findings identify significant associations between the xanthophyll carotenoids and eGFR. Further investigations are required to confirm these findings.
Will Coffee Filters Work As A Semipermeable Membrane To Protect Hydroponic Systems?
Authors: Xie Yu 
Published: November 2019

With the impact of decreasing arable land and the rapid growth of global population, more people are beginning to attach importance to hydroponic systems, which is an innovative solution that may efficiently solve this problem. The incredible growth of the global hydroponic market has already raised many entrepreneurs’ or even countries’ attentions. There is a multitude of research, which has already proven that plants grow much faster in hydroponic systems, and have more nutrients than plants grown from soil. However, many scientists also found out that having a totally closed system may also promote the spread of pathogens and pests, which can cause a great amount of economic loss to hydroponic operators. Therefore, reliable and efficient methods of preventing harmful organisms to enter the system are imperative and crucial for ensuring successful hydroponics management.
This research was done in order to discover if there is a semipermeable membrane which can block the algae or fungus outside, but allow the dissolved nutrients to enter the hydroponic system. In addition, this would reduce the cost of cleaning hydroponic systems and utilize a material that is friendly to the environment. It was hypothesized that by combining several coffee filters, which are biodegradable, this goal may be accomplished. In the first experiment, a cup with coffee filters was placed in algae water to observe if coffee filters can work efficiently for at least 3 days. In the second experiment, a “jar test” was performed for different types of filters, and it was indicated that essential coffee filters can block out algae by 100%. Finally, the last experiment involved implementing the filters in a hydroponic system. The results show that coffee filters in the hydroponic system are capable of blocking out most of algae.
Evaluation of ccomputational complexity and shortcomings of non-binary low density decoding algorithms
Authors: Glotov V V , Bashkirov A V , Astakhov N V , Pirogov A A , Panychev S N 
Published: November 2019

Abstract
Operational requirements for processing, receiving and transmitting digital information devices constantly increase, due to the need to attract significant resources, especially intellectual. This is caused by the necessity to perform the tasks that are aimed at improving the efficiency of tools, methods and specific algorithms that implement processing, receiving and transmitting information technologies. One of the most dynamically developing approaches for solving the above problem is the coding theory, in particular noise-resistant coding. As far as the energy costs are concerned, the most effective noise-resistant codes are turbo codes and the codes with a low density of parity checks. The paper reviews the algorithms that allow the decoding of non-binary codes with a low density of parity, as well as the distribution algorithm and its modifications. Their significant drawbacks and major modifications applied to eliminate them are briefly overviewed in the paper; estimates of the computational complexity of the algorithms are given.
Calculation of data processing time for an acyclic wavefront array processor
Authors: Khusainov A A 
Published: November 2019

Abstract
The wavefront array processor is a systolic structure that implements the principle of data flow control. The paper is devoted to methods for calculating the performance of an acyclic wavefront array processor. Data processing is gradient if at each moment of time all operations for which their input data are ready should be performed. It has been established that gradient processing has minimal time. A graph with weighted vertices is constructed, the maximum path length is equal to the processing time of a given amount of data for an acyclic wavefront array processor. An algorithm for the calculation the processing time of a given amount of data by this processor is proposed. The results can be used to calculate performance in the development of processors, co-processors, multi-threaded cloud applications implementing business processes, as well as non-linear pipelines associated with mass production.
About the features of the verification of VLSI class “System on a chip” for complex information systems
Authors: Petrov A B , Tarasov I E 
Published: November 2019

Abstract
The article discusses the hierarchical levels of the verification process for VLSI of the System-on-Chipclass, as well as information systems built on their basis. The increasing complexity of modern information systems creates additional requirements for the composition and complexity of the verification of such systems, including the early stages of their development. An approach to verification is proposed using a combination of software tools for modeling digital circuits at the lower levels of abstraction and specialized verification tools developed for a specific information system and implementing verification primarily at the system level. The proposed approach will enhance the performance of VLSI modeling of the System-on-Chip class, which will improve the reliability of verification of complex systems by improving test coverage. It is noted that when connecting mutually asynchronous fragments of VLSI it is necessary to carry out modeling at a high level, able to identify problems of data transmission between individual synchronous subsystems.
Obtaining a behavioral model for evaluating the definition of significant moments of the digital signal from perfect provisions in time
Authors: Pirogov A A , Bashkirov A V , Bobylkin I S , Muratov A V , Glotov V V 
Published: November 2019

Abstract
The increasing complexity of the systems-on-a-chip, as well as their raising operating frequencies, leads to the more complex and accurate design of the systems for generating clock signals. In this case, it becomes important not only to define all the characteristics that directly affect the accuracy of the generated signals, but also the practical possibility of estimating them using computer simulation. The reason for this is that the numbers of systems, which require modeling, develop faster than the computing power of a data processor. This paper discusses the possibilities of analyzing clock generation systems to estimate the value of random noise. The development of data transmission interfaces seeksto increase the speed of information transmission, whereas this development is proceeding in several directions.Firstly, the increase in speed may be achieved refining modulation systems. Another way to increase the speed of information transfer is to change the data transfer protocol. However, the most effective method of increasing the data transfer rate for any interfaces is still to increase the transmission frequency, i.e. reducing the duration of a single interval, which leads to stricter requirements for both the transmitter and the receiver involved in the physical implementation of the data transfer interface (PHY).
A device for paired zeroing of numbers in a residue system
Authors: Selivanova M V , Tyncherov K T , Ikhsanova F A , Kalmykov I A , Olenev A A 
Published: November 2019

Abstract
The paper studies the problem of developing a high-speed number correction device in computing systems operating in the basis of non-positional arithmetic in residual classes. The topicality of the problem is necessitated by the search of solutions allowing reducing the time for digital processing of signals in non-positional neuroprocessors. The device allows correcting errors with single and multiple control bases of the residue system. The work presents the structure of the unit that realizes the paired zeroing on numbers in the system of residual classes. It was demonstrated that the suggested solutions allow appreciably reducing the time consumption by digital processing of signals in neuroprocessors destined for operations of summation and multiplication.
Architectures of high-performance VLSI for custom computing systems
Authors: Tarasov I E 
Published: November 2019

Abstract
The article deals with the design of specialized VLSI designed for the construction of high-performance computing systems. Common options for building such systems are general-purpose processors (CPUs), graphics accelerators (GPUs) that work in the mode of general-purpose computing acceleration, and FPGAs that are configured to implement a specific task or a narrow class of tasks. If there is a demanded class of tasks with specific requirements for computing resources, it is possible to develop a specialized VLSI that is more effective than CPU and GPU in terms of the use of crystal resources, and more productive than FPGA due to the use of hardware-implemented connections instead of programmable cells and switched trace lines. Taking into account modern trends in microelectronics and existing technological lag from leading global manufacturers, an important role is played by the choice of VLSI architecture as well as the use of architectural and circuit design solutions that reduce technical risks and provide solutions to urgent problems for Russian companies.