bluuebunny/crossref_metadata_2025_split huggingface dataset:
BELAJAR DARI KECERDASAN LOKAL: STUDI TENTANG KAMPUNG NAGA
Authors: Dewi Pancawati 
Published: June 2020

Title: Learning from the Local Intelligence: Study in Kampung Naga
Changes that occur in Kampung Naga houses can not be avoided. Change is adapted to the development of the times adjusting to the evolving socio-economic and cultural conditions. The method used in this study is the Interpretive-Historical. The key to this research method is interpretation. This is done to try to understand the phenomena that exist in the field (a subjective group of people) and bring them to an objective interpretation. Material changes to the layout and the house can not be avoided in order to customize their new needs and technology of today. Changing patterns of house structure and the addition of new space shows the friendliness and openness of Kampung Naga society in welcoming the tourists. The effort to preserve their traditions still shows strong identity in Kampung Naga society in the face of changing times. Placement the hearth at this time is tend to be permanent, though it can be shifted layout. The hearth has an important role in people's daily lives in Kampung Naga since old time to be maintained to this day.
PENGARUH KETERSEDIAAN MODAL DAN LAHAN TERHADAP PROSES TRANSFORMASI SPASIAL HBE DI KAMPUNG KARANGASEM, SLEMAN
Authors: Puspita Luluk Rani , Rahmi Dwita Hadi 
Published: June 2020

Title: The Effect of Capital and Land Availability on The Spatial Transformation Process at Kampung Karangasem, Sleman
Kampung Karangasem as one of Kampung located in pheriphery of Yogyakarta has very rapid spatial development since the establishment of UGM and UNY. People’s initiatives to seize this opportunity, make spatial change from housing into home based enterprises. This study aims to determine the effect of capital and land availability on the spatial transformation process of HBE at Kampung Karangasem. Method used in this study is deductive-qualitative. Data collective by “participant as observer” and mapping.The result of this study indicate that the availability of capital and land has an influence of strategy in the process of transformation from house into a home-based enterprises. Limited capital ownership influences the transformation process of horizontal sharing of space, horizontal shifting of space, horizontal extending of space and vertical extending of space. If homeowner have enough capital, it will make transformation vertical extending of space. The influence of the availability of land is the house that still have enough land with sufficient area will choose to use the horizontal extending of space strategy, while the vertical extending of space strategy is chosen if there is no available vacant land.
Calcium dobesilate – a perfect stranger
Authors: Bogachev V. Yu. , Boldin B. V. , Rodionov S. V. , Dzhenina O. V. 
Published: June 2020

Pharmacotherapy plays a key role in the treatment of chronic venous diseases and their complications. This category of patients traditionally uses a variety of phlebotropic drugs, the vast majority of which are of plant origin, introducing specific therapeutic features due to decreased bioavailability and, consequently, the presence of a dose-dependent effect. That is why the modern trend in pharmacotherapy of chronic venous diseases is the use of phlebotropic drugs that have high bioavailability with rapid achievement of therapeutic concentration, as well as demonstrating a polyvalent mechanism of action on the main pathogenetic mechanisms of development and progression of chronic venous diseases. One of such preparations is calcium dobesilate, which is a calcium salt of 2,5-dihydroxybenzenesulfonic acid (C12H10CaO10S2) obtained by chemical synthesis. In terms of pharmacological properties calcium dobesilate belongs to capillary protectors with more pronounced pluripotent effect on venous and lymphatic sections of the microcirculation. To date, calcium dobesilate is the only synthetic phlebotropic drug registered in the Russian Federation.Indications for the prescription of calcium dobesilate are microangiopathies of various genesis, but primarily associated with chronic venous and lymphatic failure.Numerous experimental and clinical studies demonstrate a high clinical efficacy of calcium dobesilate regarding major venospecific symptoms and syndromes, for the elimination of which the drug can be prescribed in a standard daily dose of 1500 mg, both in monotherapy and in combination with other drugs.Calcium dobesilate therapy is usually performed without undesirable reactions, the risk of which is low when using standard recommended daily doses of the preparation 500-1500 mg.
Effectiveness of treatment of patients with superficial vein thrombosis associated with varicose veins in real clinical practice
Authors: Burleva E. P. , Leshchinskaya A. Yu. , Kremenevskiy O. M. , Zasorin A. A. 
Published: June 2020

Introduction. Approaches to the treatment of superficial vein thrombosis associated with varicose veins (V-SVT) has undergone significant changes in the last decade as a result of randomized clinical studies on the effectiveness of anticoagulant therapy in V-SVT. At the same time, there is still not enough specific clinical data covering the results of treatment of patients with V-SVT and reflecting the willingness of doctors to abandon active surgical tactics in this variant of thrombophlebitis.Aim – study the effectiveness of treatment of patients with superficial vein thrombosis associated with varicose veins (V-SVT) in real clinical practice.Materials and methods. A retrospective non-comparative study of the results of treatment of 82 patients with V-SVT (w/m – 49/33, mean age – 55.5 years) who underwent of treatment in two departments of vascular surgery in 2019. A retrospective analysis of outpatient records of 81 patients with V-SVT discharged from the hospital was performed. Clinical and ultrasound parameters were highlighted to summarize the results. The methods of standard statistics applied using the program MS Excel 2016.Results. The localization of thrombus in the system of the great saphenous vein (GSV) in 68 cases (82.9%), in system of the small saphenous vein (SSV) in 8 cases (9.8%), in both systems – 6 cases (7.3%). Localization of the top of the thrombus 20–80 mm from the sapheno-femoral (SFJ)/sapheno-popliteal junctions (SPJ) – 60 (67.5%), passage into deep veins – 12 (13.4%), localization of the top of the thrombus to the level of the middle third of the thigh – 8 (9.0%), in the tributaries and trunk of the GSV/SSV on the leg below knee – 9 (10.1%). The type of the thrombus proximal part: occlusal – 61 (68.5%), non-occlusal – 6 (6.7%), floating – 22 (24.7%). Surgical interventions: high ligation of SFJ – 49 (55.1%), dissection of the SPJ – 8 (9.0%), high ligation + thrombectomy – 12 (13.4%). Conservative treatment at vascular surgery department – 20 (22.5%). Recovery – 81 (98.7%). Death – 1 (massive pulmonary embolism upon admission). After 1 month in the outpatient period, a complete relief of the inflammatory process was registered in 76 patients (93.8%), partial in 5 patients (6.2%). Regression of the thrombotic process: complete in 7 patients (8.7%), partial in 74 patients (91.3%). A case of successful treatment of a patient with V-SVT using parnaparin sodium given in this article.Conclusion. It is necessary to revise the drug therapy of V-SVT with increasing dose of anticoagulants and prolongation of anticoagulant therapy to achieve effective results in regression of thrombotic process in superficial veins of the lower extremities.
Differential diagnosis and treatment of Morton’s neuroma in ambulatory surgical practice
Authors: Korobkov V. N. , Filippov V. A. 
Published: June 2020

Introduction. Diagnosis of Mortoan neuroma in some cases does not cause much difficulty and is based on typical signs, but in some cases it presents certain difficulties. Therapeutic tactics for this disease involves the use of conservative or surgical treatment.Aim. Study of the results of differential diagnosis of Morton’s neuroma in the practice of an outpatient surgeon.Material and methods. A study of the results of diagnostics and differential diagnostics in 15 patients with chronic foot pain at the age of 28 to 46 years was conducted. Among them, there were 14 women and 1 man. Differential diagnostics for foot pain syndromes allowed us to distinguish three groups of patients. The first group included 7 patients with Morton’s neuroma. The second group included 4 patients with plantar fasciitis and the third group-4 patients with arthritis, synoviitis of the metatarsophalangeal joints. To conduct differential diagnostics, we used anamnesis, physical examination, and data from instrumental diagnostic methods.Results. Diagnosis of Morton’s neuroma was based on the use of standard research methods (anamnesis, data from a physical instrumental examination of the foot). It should be noted the importance of ultrasound examination of the soft tissues of the foot on the plantar surface for the diagnosis of Morton’s neuroma. This allows for differential diagnosis with foot diseases such as plantar fasciitis and metatarsophalangeal joint synovitis, which may show similar symptoms.Conclusion. Morton’s neuroma is not a rare disease of the foot, which in the initial stages of the disease has a blurred clinical picture, similar to other diseases of the foot. This can lead to diagnostic errors, but the use of modern diagnostic methods, including sonographic methods, allows in most cases to establish an accurate diagnosis and choose an appropriate treatment strategy.
Optimization of dam's spillway design under climate change conditions
Authors: Ferdowsi Ahmad , Mousavi Sayed-Farhad , Farzin Saeed , Karami Hojat 
Published: June 2020

AbstractThe present research introduces a model to find the best shape of a dam's spillway under climate change impacts, considering a benchmark problem (i.e., Ute Dam's labyrinth spillway in the Canadian River watershed, New Mexico, USA). A spillway design is based not only on historical data but also on the future hydrologic events. Climate variables were predicted for the years 2021–2050 based on three representative concentration pathway (RCP2.6, RCP4.5, and RCP8.5) scenarios of the general circulation model from the fifth phase of the coupled model intercomparison project (CMIP5) using the statistical downscaling model. Streamflow at the USGS 07226500 streamgage was simulated by a rainfall–runoff model with predicted data. Instantaneous peak flow was estimated using an empirical method. Flood frequency analysis was used for the estimation of the design flood. The shuffled frog-leaping algorithm (SFLA) is used to optimize a labyrinth spillway design and its results were compared with two other nature-inspired algorithms: invasive weed optimization (IWO) and cuckoo search (CS). The spillway was optimized once with the actual design flood (16,143 m3/s) and again with the design flood under climate change (12,250 m3/s). Results revealed that optimization with realistic design flood reduced the concrete volume of the spillway by 37% and under climate change by 43% using the SFLA.
Fluoro Aryl Azides: Synthesis, Reactions and Applications
Authors: Leyva Elisa , Platz Matthew S. , Loredo-Carrillo Silvia E. , Aguilar Johana 
Published: June 2020

Background:
The complex photochemistry of aryl azides has fascinated scientists
for several decades. Spectroscopists have investigated the intermediates formed by
different analytical techniques. Theoretical chemists have explained the intrinsic interplay of
intermediates under different experimental conditions.

Objective & Method:
A complete understanding of the photochemistry of a given fluoro
aryl azide is a basic requisite for its use in chemistry. In this review, we will discuss the
synthesis of several fluoro substituted aryl azides and the reactions and intermediates generated
upon photolysis and thermolysis of these azides and some examples of their applications
in photoaffinity labeling and organic synthesis.

Conclusion:
In spite of the extensive research on the photochemistry of fluoro aryl azides, there are some areas
that remain to be investigated. The application of this reaction in the synthesis of novel heterocyclic compounds
has not been fully studied. Since fluorophenyl azides are known to undergo C-H and N-H insertion reactions,
they could be used to prepare new fluorinated molecules or in the biochemical process known as photoaffinity
labeling.
Ionic Liquids in Agrochemistry
Authors: Ten Assel , Zazybin Alexey , Zolotareva Darya , Dauletbakov Anuar , Rafikova Khadichahan , Yu Valentina , Giner Beatriz 
Published: June 2020

:
In this review article, we present the latest research in the field of ionic liquids
containing biologically active anions and cations, their potential application in the field of
agrochemistry and agriculture. The article describes examples of the use of ionic liquids as
herbicides, fungicides, antimicrobial agents, deterrents and plant growth stimulants. It also
indicates the advantages and disadvantages of using ionic liquids, such as their multitasking,
toxicity, thermal stability and solubility in water in comparison with commercial chemicals.
Readers will find in the article the prospects for the use of ionic liquids in agriculture, as
well as the high value of using ILs as multifunctional biologically active substances.
Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors
Authors: Zhang Yan , Yu Niefang 
Published: June 2020

Background:
Fibroblast growth factors (FGFs) and their high affinity receptors (FGFRs)
play a major role in cell proliferation, differentiation, migration, and apoptosis. Aberrant FGFR signaling
pathway might accelerate development in a broad panel of malignant solid tumors. However,
the full application of most existing small molecule FGFR inhibitors has become a challenge due to
the potential target mutation. Hence, it has attracted a great deal of attention from both academic and
industrial fields for hunting for novel FGFR inhibitors with potent inhibitory activities and high selectivity.

Objective:
Novel 5-amino-1H-pyrazole-1-carbonyl derivatives were designed, synthesized, and
evaluated as FGFR inhibitors.

Methods:
A series of 5-amino-1H-pyrazole-1-carbonyl derivatives were established by a condensation
of the suitable formyl acetonitrile derivatives with either hydrazine or hydrazide derivatives in
the presence of anhydrous ethanol or toluene. The inhibitory activities of the target compounds were
screened against the FGFRs and two representative cancer cell lines. Tests were carried out to observe
the inhibition of 8e against FGFR phosphorylation and downstream signal phosphorylation in
human gastric cancer cell lines (SNU-16). The molecular docking of all the compounds were performed
using Molecular Operating Environment in order to evaluate their binding abilities with the
corresponding protein kinase.

Results:
A series of 5-amino-1H-pyrazole-1-carbonyl derivatives have been designed and synthesized,
screened for their inhibitory activities against FGFRs and cancer cell lines. Most of the target
compounds showed moderate to good anti-proliferate activities against the tested enzymes and cell
lines. The most promising compounds 8e suppressed FGFR1-3 with IC50 values of 56.4, 35.2, 95.5 nM,
and potently inhibited the SNU-16 and MCF-7 cancer cells with IC50 values of 0.71 1.26 μM, respectively.
And 8e inhibited the growth of cancer cells containing FGFR activated by multiple mechanisms. In
addition, the binding interactions were quite similar in the molecular models between generated
compounds and Debio-1347 with the FGFR1.

Conclusion:
According to the experimental findings, 5-amino-1H-pyrazole-1-carbonyl might serve
as a promising template of an FGFR inhibitor.
Identification of Key mRNAs, miRNAs, and mRNA-miRNA Network Involved in Papillary Thyroid Carcinoma
Authors: Han Wei , Lu Dongchen , Wang Chonggao , Cui Mengdi , Lu Kai 
Published: June 2020

Background:
In the past decades, the incidence of thyroid cancer (TC) has been gradually increasing, owing to
the widespread use of ultrasound scanning devices. However, the key mRNAs, miRNAs, and mRNA-miRNA network in
papillary thyroid carcinoma (PTC) has not been fully understood.

Material and Methods:
In this study, multiple bioinformatics methods were employed, including differential expression
analysis, gene set enrichment analysis, and miRNA-mRNA interaction network construction.

Results:
First, we investigated the key miRNAs that regulated significantly more differentially expressed genes based on
GSEA method. Second, we searched for the key miRNAs based on the mRNA-miRNA interaction subnetwork involved
in PTC. We identified hsa-mir-1275, hsa-mir-1291, hsa-mir-206 and hsa-mir-375 as the key miRNAs involved in PTC
pathogenesis.

Conclusion:
The integrated analysis of the gene and miRNA expression data not only identified key mRNAs, miRNAs,
and mRNA-miRNA network involved in papillary thyroid carcinoma, but also improved our understanding of the
pathogenesis of PTC.
México hoy
Authors: Cabrera Morales Sergio 
Published: June 2020

<p>Reseña al libro Neoliberalismo. Utopías y financiamiento en México, Coordinadoras: Eugenia Correa y Alicia Girón, UNAM, 2020.</p><p>El contenido de la presente compilación se destacan las características: el horizonte temático que abarca es variado y se aborda desde varias perspectivas teóricas y metodológicas; así como desde la perspectiva del sector externo, la economía nacional en varios ámbitos.</p>
Penerapan Aplikasi 1001 Majas guna mempermudah pemahaman majas siswa SMA di Kota Malang
Authors: Sumantri Dini Anggita , Anggraini Wulan Ria , Anggraini Purwati 
Published: June 2020

Majas dalam pembelajaran bahasa Indonesia merupakan sebuah objek kajian yang menarik untuk diteliti. Hal ini disebabkan karena kurangnya pengetahuan siswa mengenai majas, sehingga memerlukan sebuah aplikasi yang dapat membantu dan memudahkan siswa dalam belajar majas. Penelitian ini bertujuan mendeskripsikan penerapan Aplikasi 1001 Majas guna membantu dan mempermudah pemahaman mengenai majas pada siswa SMA di Kota Malang. Penelitian ini menggunakan metode persentase deskriptif. Responden dalam penelitian ini adalah siswa kelas X SMAN 7 Malang dan MA Al-Irtiqo’ sebagai populasi penelitian. Total terdapat 5 kelas di SMAN 7 Malang dan 2 kelas di MA Al-Irtiqo’, berdasarkan kondisi tersebut maka digunakan teknik simple random sampling untuk menentukan sampel penelitian, sehingga didapatkan siswa kelas X1 dan X3 di SMAN 7 Malang serta Kelas X1 dan X2 di MA Al-Irtiqo’ sebagai sampel penelitian. Teknik pengumpulan data menggunakan wawancara dan kuesioner. Teknik analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa (1) penerapan Aplikasi 1001 Majas mampu memudahkan pemahaman mengenai majas dalam pembelajaran bahasa Indonesia dan (2) keberadaan Aplikasi 1001 Majas juga dapat berperan sebagai media pembelajaran yang dapat memberikan manfaat yang berguna pada siswa.
Book Review: Research for Social Justice
Authors: Fulton Amy E. 
Published: June 2020

Research for Social Justice: A Community-Based ApproachAuthor: Adje van de Sande & Karen SchwartzPublished: 2011Published By: Fernwood Publishing, Nova Scotia, CanadaPaperback ISBN: 978-1-55266-441-4Number of Pages: 190
In recognition of the limited amount of social work research literature that is congruent with social work’s social justice values, van de Sande and Schwartz published Research for Social Justice: A Community-Based Approach. As professors at the Carleton University School of Social Work located in Ottawa, Ontario, Canada, the authors built on their classroom teaching experiences in order to develop this engaging, illustrative, and practical text. The book provides a concise guide to the structural approach to community-based research aimed toward a target audience of social work students, social work practitioners, and other learners in the social sciences disciplines.
Fracture Resistance of Remaining Buccal Cusps in Maxillary Premolar Ceramic Onlay Restorations
Authors: Thainimit I , Totiam P , Wayakanon K 
Published: June 2020

Clinical Relevance
Preparation designs for bondable partial coverage restorations are varied. As little as 1 mm of thickness of a remaining buccal cusp can be kept when restoring maxillary premolars with bondable partial coverage restorations.

SUMMARY
Indirect partial coverage restorations have become increasingly popular in recent years as new and improved adhesive materials have been developed. These restorations can preserve substantial amounts of tooth structure. However, there are some aspects of indirect partial coverage restorations for which no clear protocol exists. This study investigated the minimal thickness of the nonfunctional cusp that must be left in a bondable ceramic partial coverage restoration in order to resist compressive force. Ninety sound human maxillary premolar teeth were obtained and used in one of the following three ways. Ten of the sound teeth were used as a control without further preparation. Forty other sound teeth had cavities designed and were tested as “unrestored teeth.” The remaining 40 sound teeth received not only cavities but also restoration and were tested as “restored teeth.” Both the restored group and the unrestored group were prepared either with an overlay or with varying buccal cusp thicknesses of 1, 2, or 3 mm. In total, there were nine experimental groups with 10 in each group (n=10). The prepared teeth were digitally scanned, and the restorations were designed and fabricated from IPS e.max computer-aided design (CAD) software using a CAD/CAM machine (CEREC MC XL, Dentsply Sirona, Bensheim, Germany). The restorations were cemented with resin cement (Panavia V5). All samples underwent thermocycling and dynamic fatigue simulating approximately one year of actual use. All the teeth were then subjected to compressive load until the point of fracture, and the mode of each fracture was analyzed. Results show that the fracture resistance of the restored groups was significantly higher than the nonrestored groups (p&lt;0.001) and the sound teeth (p&lt;0.05). Crucially, this study determined that 1 mm of remaining buccal cusp thickness in bondable partial coverage restorations for maxillary premolars is sufficient to withstand normal use of the tooth without breakage.
Enterotoxin and Emetic Toxin Genes Profiles and Genetic Diversity of Bacillus cereus Isolated from Food, Environmental and Clinical Samples in Serbia
Authors: Dejana Savić , Elizabeta Ristanović , Biljana Miljković Selimović , Sonja Radaković , Dragana Jošić , Zorica Lepšanović 
Published: June 2020

Abstract

Bacillus cereus, usually ingested by food, can cause two types of disease due to the presence of toxins: vomiting and diarrhea syndrome. Systemic infections can also occur. The aim was to detect genes for enterotoxins (hblA, entFM) and emetic toxin (cer) and to investigate the genetic heterogeneity of B. cereus isolates from food, environment and human stool. Identification of B. cereus was performed by means of selective medium, classical biochemical test and polymerase chain reaction (PCR). Toxin genes were detected by PCR. Typing was performed by random amplified polymorphic DNA (RAPD). EntFM gene was present in all stool and food samples and in 28/30 environmental isolates. HblA gene was present in 29/30 stool, 23/30 food and 24/30 environmental isolates. Cer gene was present in 30/30 stool, 28/30 food and 25/30 environmental isolates. The RAPD results show high heterogeneity among the isolates from each group. In the cumulative dendrogram, representative isolates from all three groups formed two clusters with a difference of 53%. The detection of toxin genes in all B. cereus isolates indicated these bacteria as potentially pathogenic and a serious threat for human health. The presence of isolates from all three groups in the same cluster suggests the existence of similar strains in the environment, food and patients, which is in line with the circulation of strains in nature through the food chain.