bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxytocin Signaling Pathway: From Cell Biology to Clinical Implications
Authors: Iovino Michele , Messana Tullio , Tortora Anna , Giusti Consuelo , Lisco Giuseppe , Giagulli Vito Angelo , Guastamacchia Edoardo , De Pergola Giovanni , Triggiani Vincenzo 
Published: May 2020

Background:
In addition to the well-known role played in lactation and parturition, Oxytocin
(OT) and OT receptor (OTR) are involved in many other aspects such as the control of maternal
and social behavior, the regulation of the growth of the neocortex, the maintenance of blood supply to
the cortex, the stimulation of limbic olfactory area to mother-infant recognition bond, and the modulation
of the autonomic nervous system via the vagal pathway. Moreover, OT and OTR show antiinflammatory,
anti-oxidant, anti-pain, anti-diabetic, anti-dyslipidemic and anti-atherogenic effects.

Objective:
The aim of this narrative review is to summarize the main data coming from the literature
dealing with the role of OT and OTR in physiology and pathologic conditions focusing on the most
relevant aspects.

Methods:
Appropriate keywords and MeSH terms were identified and searched in Pubmed. Finally,
references of original articles and reviews were examined.

Results:
We report the most significant and updated data on the role played by OT and OTR in physiology
and different clinical contexts.

Conclusion:
Emerging evidence indicates the involvement of OT system in several pathophysiological
mechanisms influencing brain anatomy, cognition, language, sense of safety and trust and maternal
behavior, with the possible use of exogenous administered OT in the treatment of specific neuropsychiatric
conditions. Furthermore, it modulates pancreatic β-cell responsiveness and lipid metabolism
leading to possible therapeutic use in diabetic and dyslipidemic patients and for limiting and even
reversing atherosclerotic lesions.
Nigella sativa Seed Protects Against Cadmium-induced Renal Toxicity in Rats
Authors: Uchendu Ikenna Kingsley , Okoroiwu Henshaw Uchechi 
Published: May 2020

Background:
Prevalence of chemical-induced renal injuries has been on a fast rise
over the years and has become the leading cause of mortality and morbidity in the society,
with environmental pollutants, heavy metals inclusive, seen as the causal agents. Recently,
the role of medicinal foods in human health has gained considerable attention.

Objective:
We investigated the protective effects of methanolic extract of Nigella sativa
(MENS) (Black seed) against cadmium-induced renal toxicity in albino rats.

Methods:
Twenty-five (25) male albino rats, weighing (150-170g), were randomly grouped
into five groups: A-E. Group B (Negative Control) received intraperitoneal administration of
cadmium chloride (CdCl2, 5mg/kg) only, group C received CdCl2 and low dose MENS
(300mg/kg, oral), group D received CdCl2 and high dose MENS (600mg/kg, oral), group E
(Positive control) received CdCl2 and Vitamin C (200mg/kg, oral), for 7 days. No treatment
was administered to group A (Normal control). Renal injury was assessed by measuring serum
levels of Na+, K+, creatinine and blood urea nitrogen (BUN) using standard methods.
The kidneys were harvested for histopathological examination.

Results:
CdCl2 induced significant nephrotoxicity with marked elevation in the levels of biochemical
markers of renal functions (p<0.05 or p<0.01); these were, however, ameliorated
by a low dose of MENS. Histopathological examination of the kidney sections supported the
biochemical findings.

Conclusion:
We conclude that Nigella sativa seed extract, at a low dose, is potentially nephroprotective
against harmful chemical toxins such as cadmium.
Effect of Process Variables on the Crevice Corrosion in Type-304 Stainless Steels
Authors: Adeniyi Adewale George , Ighalo Joshua O. 
Published: May 2020

Background:
Corrosion is a major problem in most industries making use of metals
across the world. The protection of metals and pipelines in the petroleum industry against
different forms of corrosion has been of interest to stakeholders for many years.

Objective:
In this study, the effects of NaCl concentration, crevice scaling factor and immersion
time on the percentage area attacked and the maximum depth of crevice attack in type-
304 stainless steels were investigated.

Method:
The assembly and experimentation of crevice attack in type-304 stainless steels
were according to ASTM G-78. Furthermore, the open circuit potential of the system was
determined and numerical optimisation of the process factors was conducted.

Results:
The open-circuit potential for creviced SS-304 revealed a greater susceptibility to
crevice corrosion at higher NaCl concentrations. It was observed that the percentage area attacked
and the maximum depth of attack increased with increasing NaCl concentration and
time. However, the higher scaling factors led to a lesser area and depth of attack. Numerical
optimisation revealed that the optimum value (minimum) of % area attacked and the maximum
depth of attack were 0.00005847% and 0.00984 mm at 2.43 wt% NaCl, 19.3 crevices
scaling factor and 15 days, respectively.

Conclusion:
It can be concluded that by taking appropriate measures of maintenance and
avoidance of moist environment (supplying O and H2O), the crevice corrosion of SS-304 can
be mitigated.
Influence of Personality on mHealth Use in Patients with Diabetes: Prospective Pilot Study
Authors: Su Jingyuan , Dugas Michelle , Guo Xitong , Gao Guodong (Gordon) 
Published: May 2020

Background
Mobile technology for health (mHealth) interventions are increasingly being used to help improve self-management among patients with diabetes; however, these interventions have not been adopted by a large number of patients and often have high dropout rates. Patient personality characteristics may play a critical role in app adoption and active utilization, but few studies have focused on addressing this question.

Objective
This study aims to address a gap in understanding of the relationship between personality traits and mHealth treatment for patients with diabetes. We tested the role of the five-factor model of personality traits (openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism) in mHealth adoption preference and active utilization.

Methods
We developed an mHealth app (DiaSocial) aimed to encourage diabetes self-management. We recruited 98 patients with diabetes—each patient freely chose whether to receive the standard care or the mHealth app intervention. Patient demographic information and patient personality characteristics were assessed at baseline. App usage data were collected to measure user utilization of the app. Patient health outcomes were assessed with lab measures of glycated hemoglobin (HbA1c level). Logistic regression models and linear regression were employed to explore factors predicting the relationship between mHealth use (adoption and active utilization) and changes in health outcome.

Results
Of 98 study participants, 46 (47%) downloaded and used the app. Relatively younger patients with diabetes were 9% more likely to try and use the app (P=.02, odds ratio [OR] 0.91, 95% CI 0.85-0.98) than older patients with diabetes were. Extraversion was negatively associated with adoption of the mHealth app (P=.04, OR 0.71, 95% CI 0.51-0.98), and openness to experience was positively associated with adoption of the app (P=.03, OR 1.73, 95% CI 1.07-2.80). Gender (P=.43, OR 0.66, 95% CI 0.23-1.88), education (senior: P=.99, OR 1.00, 95% CI 0.32-3.11; higher: P=.21, OR 2.51, 95% CI 0.59-10.66), and baseline HbA1c level (P=.36, OR 0.79, 95% CI 0.47-1.31) were not associated with app adoption. Among those who adopted the app, a low education level (senior versus primary P=.003; higher versus primary P=.03) and a high level of openness to experience (P=.048, OR 2.01, 95% CI 1.01-4.00) were associated with active app utilization. Active users showed a significantly greater decrease in HbA1c level than other users (ΔHbA1c=−0.64, P=.05).

Conclusions
This is one of the first studies to investigate how different personality traits influence the adoption and active utilization of an mHealth app among patients with diabetes. The research findings suggest that personality is a factor that should be considered when trying to identify patients who would benefit the most from apps for diabetes management.
A ORGANIZAÇÃO DO TRABALHO PEDAGÓGICO NO ESPAÇO DO ATENDIMENTO EDUCACIONAL ESPECIALIZADO
Authors: Claro Bernardo Jane , Silva Santos Geandra Cláudia 
Published: May 2020

Esse estudo objetiva compreender a organização do trabalho pedagógico do atendimento educacional especializado por meio da construção do estado da arte sobre essa temática, considerando as produções acadêmicas brasileiras, publicadas no período de 2008 a 2013. Para isso, foi realizado a pesquisa bibliográfica nos bancos de Teses e Dissertações de algumas universidades, em Anais de Congressos Brasileiros e em Periódicos Eletrônicos. Foram selecionadas as produções que tinham relação com a temática de investigação mencionada e, posteriormente, procedeu-se a análise e discussão dos trabalhos selecionados. Os resultados da análise apontaram alguns avanços nas ações educativas examinadas, contudo a maioria dos estudos analisados apontou a existência de problemas na organização do atendimento educacional especializado que implicam no funcionamento do serviço e em sua qualidade.
Prioritas Aspek-Aspek Tipologi Linguistik Pada Pemetaan Masalah-Masalah Kebahasaan
Authors: Umiyati Mirsa 
Published: May 2020

Tulisan ini memberikan tinjauan teoretis mengenai kajian tipologi linguistik yang dibedakan dari kajian tipologi bahasa secara struktural yang selama ini lebih akrab di kalangan linguist. Fokus penjabaran teoretis dimaksud adalah penjabaran prinsip-prinsip kerja kajian tipologi linguistik sampai dengan jabaran aspek-aspek tipologi linguistik bahasa Lokal di Indonesia yang diprioritaskan untuk dikaji. Instrumen penjaringan data lapangan, proses identifikasi sampai pemetaan masalah pada aspek ini juga dijabarkan untuk memberi jawaban dari suatu pertanyaan, Bagaimana paradigm teori tipologi linguistik melihat bahasa sebagai objek dan bagaimana melakukan penelitian pada tipologi linguistik pada bahasa manusia untuk mencapai keuniversalan bahasa?.Jabaran pemetaan masalah ranah ini juga disertai dengan jabaran solusi dan strategi menjawab pemetaan masalah-masalahnya.Pada akhirnya, tulisan ini menyimpulkan suatu rumusan tentang kontribusi kajian tipologi linguistik dalam mendesain riset proses dan produk aspek kebahasaan terutama bahasa-bahasa lokal di Indonesia. Kata kunci: tipologi bahasa, tipologi linguistik, prinsip dan parameter keuniversalan.
Las Maras Centroamericanas: ¿Víctimas o Victimarios?
Authors: García Estrada Irving 
Published: May 2020

Actualmente Latinoamérica enfrenta diversos fenómenos ligados a la(s) violencia(s); en el caso centroamericano, ha sido escenario del ejercicio de violencia, lo cual ha permeado las estructuras económicas, políticas y sociales. A mediados de 1970, bajo un sentido de identidad y pertenencia, y a través de los flujos migratorios, se empieza a gestar un fenómeno social conocido como las maras; hoy día, tal fenómeno va en aumento.
Las maras representan un problema que ha rebasado a los gobiernos involucrados, no parecen haber programas de combate al fenómeno desde una perspectiva más humana y con carácter de responsabilidad social. Se enfrenta un fenómeno violento, con una estructura primordialmente juvenil, que plantea una disyuntiva: por un lado está la aplicación de la Ley, que sin minimizar el problema lo ha llevado a situaciones extremas. En contraparte, discursos por los Derechos Humanos, muestran que el marero antes de ser delincuente es un ser humano –aspecto expuesto en estudios académicos–; si las maras asumen dicha identidad, se debe a la ausencia de alternativas de subsistencia.
Incidencia del TLC en el Subsector Lácteo en Nariño
Authors: Acosta Ortíz Linda Marcela , David María Helena 
Published: May 2020

Teniendo en cuenta que los procesos globalizadores tienen un gran impacto en las economías regionales se analiza las repercusiones que tendría un Tratado de Libre Comercio en la región; Nariño es un territorio basto en agricultura y cuyo potencial no se ha desarrollado de forma idónea dadas las condiciones de minifundio, falta de industria y una tercerización de la economía, de ahí que sea necesario adentrarse en la dinámica del subsector lácteo, siendo este uno de los más importantes para la economía del Departamento de Nariño.
El trabajo analiza las consecuencias que traería para el sector lácteo en el Departamento de Nariño, la puesta en marcha del TLC que el gobierno colombiano desea entablar con Estados Unidos, esto por medio de la cuantificación del impacto del TLC sobre el sector lácteo, así como el análisis del impacto social del mismo en la región, para finalmente hacer una propuesta desde el quehacer económico frente a este fenómeno.
Una Crónica acerca del Poder Negro en el Norte del Cauca: Algunos Elementos para su Análisis y Reflexión
Authors: Córdoba Gómez Antonio 
Published: May 2020

La expresión de Poder Negro entre los ciudadanos del Norte del Cauca, hace referencia al empoderamiento en la política local expresado en las administraciones ocupadas por miembros de la comunidad afrodescendiente y al poder burocrático referido a la capacidad de negociación con la administración departamental.
Sin embargo esta participación a nivel político-administrativo y la capacidad de negociación a nivel departamental, saca a relucir las tensiones históricas de la población afrodescendiente con la política tradicional y sus representantes, provenientes de una clase política terrateniente y esclavista, que aún hoy defiende intereses gremiales y hacendatarios, opuestos a los intereses comunitarios de indígenas y negros; ante esta disyuntiva política, el autor contrapone el peso de un proceso social y cultural, unas raíces históricas y un poder colectivo que terminan por materializarse en cada líder y superar el accionar individual.
No obstante el autor advierte el poder negro como una posibilidad cambiante que se constituye en desafío, reto, peligro y preocupación a la vez, al no estar exenta de contradicciones, riesgos y dificultades.
El Concepto de “Barbarie” y el Sistema Misional Jesuítico en Nueva España y el Noroeste Novohispano
Authors: Pacheco Rojas José De la Cruz 
Published: May 2020

La comprensión de los alcances sociales del sistema misional instrumentado por los religiosos de la Compañía de Jesús en el noroeste de Nueva España desde finales del siglo XVI y hasta avanzado el XVIII, no puede percibirse cabalmente sin tomar en consideración los procesos históricos derivados de la conquista de México, especialmente aquellos que ocurrieron durante el siglo XVI y tuvieron que ver con el tratamiento de las diversas naciones que poblaban este país. Para ello, es necesario tener presente las ideas tanto filosóficas, teológicas, jurídicas como antropológicas que sirvieron de sustento, incluida por supuesto la experiencia misional de las órdenes mendicantes, dominicos y franciscanos.
Ámbito de la Pedagogía Social en América Latina
Authors: Torres Vega Nelson 
Published: May 2020

El ámbito socio-pedagógico es el espacio disciplinar por excelencia, desde el cual se plantea la praxis de la Educación Social que propicia acciones cultivadas con los sujetos en condiciones de marginalidad e incluye su dimensión social. Es esta dimensión la que les aporta identidad como individuos, es la perspectiva sociológica de la interrelación que se realiza con individuos que se define mediante el concepto de acción social, entendida como “conducta orientada intencionalmente, de los diversos agentes sociales que constituyen un sistema de interrelaciones” (Pérez, G. 2003, p. 143). Los destinatarios de la acción socioeducativa son sujetos, grupos colectivos específicos y sectores de población de diversas características, ya sea por su edad, por su género, por su situación laboral, por su nivel educativo y cultural; por sus dificultades de socialización (física, psíquica, sociales, culturales), por su origen y ubicación en el territorio; en síntesis y de acuerdo a las problemáticas de las personas, se puede mencionar a la población en riesgo social (delincuencia, marginación, desplazamiento, exclusión, dependencia); y finalmente población en general (atención del adulto, tercera edad, desarrollo local, animación sociocultural).
El presente texto intenta describir los diversos espacios de aplicación de la Pedagogía Social en América Latina, concepto que ha estado muy cercano a la denominada educación popular, educación de adultos o educación para poblaciones en condición de vulnerabilidad, marginalidad y pobreza. Se pretende instaurar propuestas para la transformación social y educativa de la región latinoamericana, mediante un modelo de sociedad igualitaria sustentada en la formación de un nuevo ciudadano.
A Comparative Analysis of Sino-Thai College English Course Teaching——A Case of Comparison between Jiujiang University and Chiang Mai University
Authors: Yu Xiangbo , Wu Yiping 
Published: May 2020

English is one of the most common languages in the world, and it has become one of the most important subjects in various countries. The native languages of China and Thailand are not English, and both countries are located in Asia and have many similarities in geographical location and cultural background. The Ministries of Education of the two countries have successively put forward relevant policies to promote the development of English education in the country. The implementation of these policies has promoted the development of college English course teaching in the country. These factors determine that the two countries have similarities in college English course teaching for Non-English majors. However, there are differences in teaching mode and teaching staff in the two countries because of their different national conditions, which make many differences, exist in college English course teaching for non-English majors in the two countries.During the author’s career as an exchange student in Chiang Mai University, she experienced the difference of college English course teaching for non-English majors in Thai universities, so the author did some researches on the basis of the understanding of English course teaching in Thai universities. Therefore, this thesis takes Sino-Thai college English course teaching for non-English majors as the research object—takes Jiujiang University and Chiang Mai University as example, and analyses their present situation from the aspects of the development and evolution, the teaching mode, and teaching staff of college English course teaching for non-English majors. On this basis, the author make a comparative analysis of the English course teaching for non-English majors in two selected universities, then find their respective advantages and disadvantages, and put forward some suggestions on the development of Sino-Thai college English course teaching.
Discussion on the Integration of Musical Elements into the Social Practice Teaching of “The Outline of Chinese Modern and Contemporary History”
Authors: Zhou Yu 
Published: May 2020

Teachers of the ideological and political theory course should be confident in the ideological and political course, insist on the unity of explicit education and recessive education, be good at exploring the ideological and political education resources contained in other courses and teaching methods, and realize the full-time education of all employees. At present, there is still much room for improvement in the collaborative education of aesthetic education and moral education. Teachers of the ideological and political theory course should actively guide and explore the ideological and political education resources of music resources, and use the artistic discourse system to interpret the historical process of modern Chinese social development and revolution, construction, and reform, and its inherent regularity, which reflects the national history and national conditions, reflects the positive results of Marxism in China, the era, and the popularization, guiding students to profoundly understand the history and how the people chose Marxism, chose the Chinese Communist Party, chose the socialist road, and chose reform and opening up; strengthening the road self-confidence, theoretical self-confidence, institutional self-confidence, and cultural self-confidence of socialism with Chinese characteristics; earnestly establish the belief that “only socialism can save China, only socialism with Chinese characteristics can develop China.”
Studi Kelayakan Bisnis dalam Rangka Pendirian XX Cafe
Authors: Kristian Widra , Indrawan Felix 
Published: May 2020

One of the rapidly developing creative industries in Indonesia is the food and beverage or culinary industry. Currently the food and beverage industry is the sector with the largest contribution of the Indonesian economy, namely 5.5 percent of national gross domestic product and 31 percent of gross domestic product in the non-oil and gas processing industry. This makes Indonesia a high potential in the culinary field. Seeing the rapid development of the culinary world in Indonesia, more and more restaurants, cafes, or eating places are emerging in Indonesia.This study aims to examine the business profile of XX Cafe, analyze the prospects of XX Cafe business on Jl. Cihampelas, Bandung Wetan, Bandung City, West Java based on business feasibility aspects such as: legal aspects, environmental aspects, market and marketing aspects, technical and technological aspects, aspects of human resources, and financial aspects. In conducting this research, the author discusses more deeply the financial aspects. These financial aspects are analyzed using capital budgeting techniques that take into account the return period, present net value, internal rate of return, and profit index. The results of calculating capital budgeting techniques can be a consideration for investors to make decisions. After the analysis and calculation was made, XX Café is feasible to run. But apart from the results of the calculation, a capital budgeting control is also needed so that the expectations that have been made can be achieved.
Keywords: Feasibility Study, Payback Period, Internal Rate of Return, Net Present Value, Profitability Index
Menelusuri Keberhasilan dan Kendala Pemda di Provinsi Jawa Barat dalam Upaya Memperoleh Opini WTP dari BPK: Studi Kasus Pemerintah Daerah Kabupaten/Kota di Provinsi Jawa Barat
Authors: Rahayu Puji Astuti , Fettry Sylvia , Paramita Monica 
Published: May 2020

Financial management reforms to improve quality are continuously carried out. Regional financial management is carried out in an integrated system embodied in the Local Government Budget which is determined annually by regional regulations. The drafting of the Local Government Budget is guided by the Local Government Work in order to realize services to the community to achieve the goal of the state. It requires an inflow of funds to finance regional expenditure. Regional sources of revenue can be obtained from three sources: a) local own-source revenue, b) fiscal balance transfers from the central government to regions, c) other local own-source revenue. As a form of transparent and accountable regional financial management, it is necessary to prepare financial reports audited by the BPK. Based on the result of the audit, the local government experienced improvement and decreased Opinion on The Report On Local Government Finance from 2013 to 206. The opinion that has been achieved are an illustration of the success in the presenting of the financial statement and the constraints faced by the Regional Government in West Java Province in obtaining WTP Opinions from BPK. This research is descriptive, and data collection techniques are questionnaires, the study of literature from Report of Audit Findings and interviews with related parties