bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in automated techniques to identify Acinetobacter calcoaceticus–Acinetobacter baumannii complex
Authors: Bagudo Ahmad Ibrahim , Obande Godwin Attah , Harun Azian , Singh Kirnpal Kaur Banga 
Published: November 2020

Abstract

Acinetobacter species, particularly those within Acinetobacter calcoaceticus–A. baumannii complex (ACB complex), have emerged as clinically relevant pathogens in hospital environments worldwide. Early and quick detection and identification of Acinetobacter infections is challenging, and traditional culture and biochemical methods may not achieve adequate levels of speciation. Moreover, currently available techniques to identify and differentiate closely related Acinetobacter species are insufficient. The objective of this review is to recapitulate the current evolution in phenotypic and automated techniques used to identify the ACB complex. Compared with other automated or semiautomated systems of bacterial identification, matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS) demonstrates a high level of Acinetobacter species identification and discrimination, including newly discovered species A. seifertii and A. dijkshoorniae.
Effects of willingness to communicate on L2 output and leadership roles during jury discussions
Authors: Munezane Yoko 
Published: November 2020

Abstract
This paper aspires to make a unique contribution to the field through investigating the high-WTC/low-WTC interactions to explore whether the level of Willingness to Communicate (WTC) positively affects (a) the amount of communication, and (b) the frequency of taking the leadership roles during jury discussions when each member has a firm verdict. Participants in groups of 3–4 had jury discussions, after performing a courtroom drama. Oral performance data, collected during the jury discussions, were transcribed verbatim, and coded for analysis. Then, the amount of L2 output, and the frequency of leadership roles each student took, were counted. The results suggested that, overall, high-WTC learners produced a higher amount of L2 output, and took more leadership roles. However, when only one participant had an opposing verdict within the group, the holder of that opposing verdict in each group showed a tendency to produce the un-proportionately large amount of L2 output, and take the leadership roles frequently, despite his or her low-WTC.
Emotional intelligence as a mediator in the relationship between neuroticism and L2 achievement
Authors: Ożańska-Ponikwia Katarzyna , Piechurska-Kuciel Ewa , Skałacka Katarzyna 
Published: November 2020

Abstract
The present study investigates the interaction of the higher-order personality trait of Neuroticism and the lower-order personality trait of Emotional Intelligence (trait EI) in the context of foreign language acquisition (FLA). A mediation model was applied to explore the pathway from Neuroticism via trait EI to self-rated L2 skills. The reported results show that the trait EI is not only a significant predictor of the self-reported L2 speaking proficiency, but also a mediator in the relationship between Neuroticism and self-rated L2 speaking proficiency. Consequently, trait EI could be regarded as an important variable in the FLA context because its positive impact on self-perceived L2 speaking skills might diminish the negative influence of Neuroticism.
Incomplete mimesis, or when Indian dance started to narrate stories
Authors: Ganser Elisa 
Published: November 2020

Abstract
It has become customary to refer to traditional Indian performance genres as “dance-theatre” in cases where they patently display techniques of narration or storytelling, carried out through the codified and controlled use of the body in time with the music of instruments and sung lyrics. The Indic vocabulary dedicates a specific term, nṛtya, to those forms in which the narrative element clearly prevails over the abstract dance movements—where gestures and facial expressions are used to communicate emotions but the dialogues or poetic lines are assigned to a singer and not recited by the actor/dancer. However, if we look at the way in which Sanskrit theoreticians have divided the spectacular object into specific genres, things get fuzzy. The ancient theory of Indian theatre (Nāṭyaśāstra, 2nd century BC–4th century AD?), in fact, acknowledges only a binary distinction between “theatre” (nāṭya)—the conjunction of a dramatic text and its representation on stage—and “dance” (nṛtta)—movements set to a rhythm with the sole aim of producing beauty and devoid of a narrative-cum-representational function. From this perspective, the recognition of a narrative capacity in dance looks more like the fruit of great theoretical effort rather than a natural development, which has posed a number of significant challenges to literary critics, who must painstakingly negotiate between the constantly evolving genres of performance, the binding categories reiterated in the śāstras (authoritative treatises), and the newly developed aesthetic theories of drama, requiring an ever more specialized concept of dramatic mimesis. Apart from giving an overview of how the performance genres are divided and classified in the Sanskrit treatises, with an explanation of the relevant vocabulary, this article will focus on some of the theoretical problems that emerge when dance starts to narrate stories, in particular in the work of Abhinavagupta, a prominent Kashmirian philosopher writing at the turn of the first millennium.
Initial study on changes in activity of brain waves during audio stimulation using noninvasive brain–computer interfaces: choosing the appropriate filtering method
Authors: Browarska Natalia , Kawala-Sterniuk Aleksandra , Zygarlicki Jarosław 
Published: November 2020

Abstract

Objectives
In this paper series of experiments were carried out in order to check the influence of various sounds on human concentration during visually stimulated tasks performance.

Methods
The obtained data was filtered. For the study purposes various smoothing filters were tested, including Median and Savitzky–Golay Filters; however, median filter only was applied. Implementation of this filter made the obtained data more legible and useful for potential diagnostics purposes. The tests were carried out with the implementation of the Emotiv Flex EEG headset.

Results
The obtained results were promising and complied with the initial assumptions, which stated that the “relax”-phase, despite relaxing sounds stimuli, is strongly affected with the “focus”-phase with distracting sounds, which is clearly visible in the shape of the recorded EEG data.

Conclusions
Further investigations with broader range of subjects is being currently carried out in order to confirm the already obtained results.
Asymmetric Effects of Monetary Policy
Authors: Lin Tzu-Yu 
Published: November 2020

Abstract
In this paper, we first use a structural vector autoregression model to examine whether the US economy responds asymmetrically to expansionary and contractionary monetary policies. The empirical results show that monetary policy has significant asymmetric effects on output and investment. To provide an explanation of such asymmetries, we consider a nonlinear dynamic stochastic general equilibrium (DSGE) model in which collateral constraints are occasionally binding over the business cycle. The nonlinear DSGE model is able to match the empirical findings that macroeconomic aggregates react asymmetrically to positive and negative monetary policy shocks.
Are hemoglobin A1c point-of-care analyzers fit for purpose? The story continues
Authors: Lenters-Westra Erna , English Emma 
Published: November 2020

Abstract

Objectives
Point-of-care (POC) analyzers are playing an increasingly important role in diabetes management but it is essential that we know the performance of these analyzers in order to make appropriate clinical decisions. Whilst there is a growing body of evidence around the more well-known analyzers, there are many ‘new kids on the block’ with new features, such as displaying the presence of potential Hb-variants, which do not yet have a proven track record.

Methods
The study is a comprehensive analytical and usability study of six POC analyzers for HbA1c using Clinical and Laboratory Standards Institute (CLSI) protocols, international quality targets and certified International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and National Glycohemoglobin Standardization Program (NGSP) Secondary Reference Measurement Procedures (SRMP). The study includes precision (EP-5 and EP-15), trueness (EP-9), linearity (EP-6), sample commutability (fresh, frozen and lyophilized), interference of Hb-variants (fresh and frozen samples).

Results
Only two of the six analyzers performed to acceptable levels over the range of performance criteria. Hb-variant interference, imprecision or variability between lot numbers are still poor in four of the analyzers.

Conclusions
This unique and comprehensive study shows that out of six POC analyzers studied only two (The Lab 001 and Cobas B101) met international quality criteria (IFCC and NGSP), two (A1Care and Innovastar) were borderline and two (QuikReadgo and Allegro) were unacceptable. It is essential that the scientific and clinical community are equipped with this knowledge in order to make sound decisions on the use of these analyzers.
Handshake antimicrobial stewardship as a model to recognize and prevent diagnostic errors
Authors: Searns Justin B. , Williams Manon C. , MacBrayne Christine E. , Wirtz Ann L. , Leonard Jan E. , Boguniewicz Juri , Parker Sarah K. , Grubenhoff Joseph A. 
Published: November 2020

Abstract

Objectives
Few studies describe the impact of antimicrobial stewardship programs (ASPs) on recognizing and preventing diagnostic errors. Handshake stewardship (HS-ASP) is a novel ASP model that prospectively reviews hospital-wide antimicrobial usage with recommendations made in person to treatment teams. The purpose of this study was to determine if HS-ASP could identify and intervene on potential diagnostic errors for children hospitalized at a quaternary care children’s hospital.

Methods
Previously self-identified “Great Catch” (GC) interventions by the Children’s Hospital Colorado HS-ASP team from 10/2014 through 5/2018 were retrospectively reviewed. Each GC was categorized based on the types of recommendations from HS-ASP, including if any diagnostic recommendations were made to the treatment team. Each GC was independently scored using the “Safer Dx Instrument” to determine presence of diagnostic error based on a previously determined cut-off score of ≤1.50. Interrater reliability for the instrument was measured using a randomized subset of one third of GCs.

Results
During the study period, there were 162 GC interventions. Of these, 65 (40%) included diagnostic recommendations by HS-ASP and 19 (12%) had a Safer Dx Score of ≤1.50, (Κ=0.44; moderate agreement). Of those GCs associated with diagnostic errors, the HS-ASP team made a diagnostic recommendation to the primary treatment team 95% of the time.

Conclusions
Handshake stewardship has the potential to identify and intervene on diagnostic errors for hospitalized children.
“To my soldier friend Klaus from MARIANNE”
Authors: Hess Jan 
Published: November 2020

Abstract
This essay focusses on the peritexts of Klaus Mann’s private diaries. On the basis of the diary manuscripts, various examples and types of peritexts as well as their implementation in the partial edition published first by Spangenberg and afterwards by Rowohlt are presented and analysed with regard to their significance for the main text of the diary. Based on these examples at least two aspects are elaborated that must be taken into account for a complete, academic edition of the diaries:

the inseparable correlation between diary text and text medium,

the meaning of the diaries as a form of use and as a form of expression as well.
Beiwerk als Werk
Authors: Bernhart Toni 
Published: November 2020

Abstract
After Love Letters by Christopher Strachey in 1954, Stochastische Texte by the mathematician Theo Lutz in 1959 were the first successful attempt in the world to create a literary text through a computer. In 2019, Lutz’s archive was acquired by the German Literature Archive (Deutsches Literaturarchiv Marbach). It includes a large number of previously undiscovered and unpublished items which made possible the attempt to reconstruct the generation of the text in a number of steps. Lutz’s experiment was inspired by the philosopher Max Bense, whose work was assisted by a young student, Rul Gunzenhäuser, who would himself later prove to be a pioneer in informatics. It took its starting point from words extracted from the novel Das Schloss by Franz Kafka. Lutz subsequently wrote a computer program in order to generate a randomly assembled text on a Zuse Z 22 machine. In a final step, the text was then poetically revised by the author.
Patents versus rewards: the implications of production inefficiency
Authors: Bagchi Aniruddha , Mukherjee Arijit 
Published: November 2020

Abstract
It is believed that if there is no informational asymmetry between firms and the government, firms could be remunerated for innovation using optimal taxation rather than patents. We show that under reasonable conditions (such as the government’s inability to customise the tax rate for each firm), patent protection is preferable to a tax/subsidy scheme if the marginal costs of the imitators are sufficiently higher than that of the innovator. Otherwise, the tax/subsidy scheme is preferable. These results hold under Cournot and Bertrand competition with product differentiation, but not for the case of Bertrand competition with homogeneous products. We rationalise these findings as the results of a trade-off between the distortions induced by monopoly under patents and production inefficiency under the tax/subsidy scheme.
The Right to Health and Resource Allocation. Who Gets What and Why in the COVID-19 Pandemic
Authors: Smorto Guido 
Published: November 2020

Abstract
The COVID-19 outbreak has led to a worldwide, substantial increase in the demand for pharmaceuticals, hospital beds, ventilators, and medical supplies. When needs suddenly exceed demand worldwide, resources may quickly become scarce in relation to potential demand, so that strict rationing is the only viable response. Against this backdrop, this paper scrutinizes the rationales for prioritization of scarce resources, and it questions the actual role and reach of the market with regard to resources that are essential to deliver health care, especially in times of severe shortage, such as during a global pandemic.
Three-dimensional elastic-plastic damage constitutive model of wood
Authors: Zhang Lipeng , Xie Qifang , Zhang Baozhuang , Wang Long , Yao Jitao 
Published: November 2020

Abstract
A 3D combined elastic-plastic damage constitutive model for wood is proposed within the theoretical framework of classical plasticity and continuum damage mechanics (CDM). The model is able to describe the various behavior of wood under loading, including the orthotropic elasticity, strengths inequality under tension and compression in each orthotropic direction, ductile softening under longitudinal compression, brittle failure under transverse tension, and parallel shearing, densification hardening under transverse compression. Hoffman criterion and a set of eight separate failure criteria were used to define wood yielding and damage initiation, respectively. Isotropic hardening was assumed after yielding and defined by an exponential type function. The constitutive model was implicitly discretized using backward Euler method, solved through the return mapping algorithm and implemented into ABAQUS through the user-defined material subroutine (UMAT). The proposed model was firstly verified by material property tests considering different stress states: monotonic and repeated tension and compression (in both parallel and perpendicular-to-grain directions), parallel-to-grain shearing, and the interactions between perpendicular-to-grain compression/tension and parallel-to-grain shearing, etc. Mechanical behavior of typical structural elements was further simulated to validate the proposed constitutive model.
Integrated Ca2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes
Authors: Malkovskiy Andrey V. , Ignatyeva Nadezda , Dai Yuanyuan , Hasenfuss Gerd , Rajadas Jayakumar , Ebert Antje 
Published: November 2020

Abstract
We developed a new approach for combined analysis of calcium (Ca2+) handling and beating forces in contractile cardiomyocytes. We employed human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from dilated cardiomyopathy (DCM) patients carrying an inherited mutation in the sarcomeric protein troponin T (TnT), and isogenic TnT-KO iPSC-CMs generated via CRISPR/Cas9 gene editing. In these cells, Ca2+ handling as well as beating forces and –rates using single-cell atomic force microscopy (AFM) were assessed. We report impaired Ca2+ handling and reduced contractile force in DCM iPSC-CMs compared to healthy WT controls. TnT-KO iPSC-CMs display no contractile force or Ca2+ transients but generate Ca2+ sparks. We apply our analysis strategy to Ca2+ traces and AFM deflection recordings to reveal maximum rising rate, decay time, and duration of contraction with a multi-step background correction. Our method provides adaptive computing of signal peaks for different Ca2+ flux or force levels in iPSC-CMs, as well as analysis of Ca2+ sparks. Moreover, we report long-term measurements of contractile force dynamics on human iPSC-CMs. This approach enables deeper and more accurate profiling of disease-specific differences in cardiomyocyte contraction profiles using patient-derived iPSC-CMs.
LOTUS-domain proteins - developmental effectors from a molecular perspective
Authors: Kubíková Jana , Reinig Rebecca , Salgania Harpreet Kaur , Jeske Mandy 
Published: November 2020

Abstract
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.
Research on the application of liquid-liquid extraction-gas chromatography-mass spectrometry (LLE-GC-MS) and headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) in distinguishing the Baiyunbian aged liquors
Authors: Zhou Rong , Chen Xiao , Xia Ying , Chen Maobin , Zhang Yu , Li Qin , Zhen Da , Fang Shangling 
Published: November 2020

Abstract
The purpose of the study was to reveal the differences of the flavor compounds among five Baiyunbian aged liquors by liquid-liquid extraction-gas chromatography-mass spectrometry (LLE-GC-MS) and headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS). In optimizing the LLE parameters, an extractant, methyl tert-butyl ether, was found which has a good extract effect and has never been used for the extraction of liquor flavor substances. Then the optimized LLE method has been applied to comprehensively analyze flavor compounds in 3-year-storage liquors (3Y), 5Y, 12Y, 15Y, and 20Y of Baiyunbian liquors combined with GC-MS. The results showed that the number and concentration of total flavor compounds also enhanced with the increase of cellaring ages. The total concentration of flavor compounds in 20Y was the highest (4543.23 mg/L), and the 3Y was the lowest (3984.96 mg/L). Among them, the significant differences among five samples were esters, alcohols, acids and nitrogen-containing compounds. Cluster analysis was used to analyze the aromas profiles by LLE-GC-MS, which revealed relationship among five samples. The results showed that the similarity of the samples was highest between 15Y and 20Y, followed by 3Y and 5Y. The characteristic flavors fingerprints of five kinds of Baiyunbian aged liquors were established by HS-GC-IMS. The results showed that the characteristic peaks in GC-IMS 3D spectra corresponding to flavor compounds can effectively characterize the sample information areas. The sectional intensities of 60 characteristic peaks in the corresponding three-dimensional spectra were selected as variables. After the principal components analysis (PCA) was used to reduce information dimensionality, it was further distinguished by HS-GC-IMS that 3Y and 5Y can be completely separated, but 15Y and 20Y were very similar and cannot be completely distinguished. The obtained results are valuable for the in-depth understanding and further study of flavors of Baiyunbian liquors.
A nonlocal problem for a differential operator of even order with involution
Authors: Kalenyuk Petro I. , Baranetskij Yaroslav O. , Kolyasa Lubov I. 
Published: November 2020

Abstract
We study a nonlocal problem for ordinary differential equations of

2
⁢
n

{2n}

-order with involution. Spectral properties of the operator of this problem are analyzed and conditions for the existence and uniqueness of its solution are established. It is also proved that the system of eigenfunctions of the analyzed problem forms a Riesz basis.
Calcium and s100a1 protein balance in the brain–heart axis in diabetic male Wistar rats
Authors: Kasozi Keneth Iceland , Nakimbugwe Dorothy , Ninsiima Herbert Izo , Kasolo Josephine , Matama Kevin , Safiriyu Abass Alao , Owembabazi Elna , Ssempijja Fred , Okpanachi Alfred Omachonu , Valladares Miriela Betancourt 
Published: November 2020

Abstract

Objectives
Calcium deregulation in diabetes mellitus (DM) is central to the brain–heart axis pathology. This has led to the use of medical plants in complementary medicine such as Amaranthus hypochondriacus (GA). The objective of the study was to establish the effects of grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels on the brain–heart axis in diabetic male Wistar rats.

Methods
The study involved six groups (n=5) with DM being induced in 20 rats. To the diabetic rats, Group I received mixtard®, Group II was positive control, Groups III and IV received GA feed supplementation at 25 and 50%. In the nondiabetic rats (n=10), Group V received 50% grain amaranth while Group VI was the negative control. The brain and heart tissues were harvested after five weeks and processed using standard methods.

Results
Grain amaranth feed supplementation led to improved calcium levels in DM as compared to the positive control. This also led to increased s100a1, antioxidant levels in the brain–heart axis during DM. This then protected the tissues against oxidative damage, thus preserving tissue function and structure.

Conclusions
Grain amaranth’s actions on calcium signaling subsequently affected s100a1 protein levels, leading to improved tissue function in diabetes.