bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Inclusive Pedagogies in HE through an Understanding of the Learner-Consumer: Promiscuity, Hybridisation, and Innovation
Authors: Partington Angela 
Published: March 2020

AbstractThis article contributes to debates about how to respond to the changing profile of Higher Education (HE) students, and the marketisation of HE, by challenging prevailing views about student engagement, in order to develop learner-centric and inclusive pedagogies which are relevant to the twenty-first century. The concepts of ‘participatory culture’ and ‘co-creativity’ are often associated with the digital world in which the current generation of students have grown up. But it is a mistake to assume that some learning styles are inherently more participatory than others: participation is not an effect of the medium or form, (analog vs digital), or the space (actual vs virtual), or the mode of interaction a (face-to-face vs networked) through which the learner participates – it is an effect of the practices involved. Students engage with a complex network of both digital and analog texts and spaces, and it is this postdigital hybrid setting within which student engagement takes place. Marketisation provides an opportunity to actively demonstrate our commitments to student-centredness and inclusive practice, by transcending the binary opposition between ‘Student as Partner’ and ‘Student as Consumer’ and recognizing that students are learner-consumers, and allowing students’ diversity to drive innovation, rather than continuing to disempower students by bolstering practices which privilege some learning styles above others, informed by the assumption that innovation is technology-led.
The application of dried amniotic membrane scaffold with adipose derived-mesenchymal stem cell seeding as graft in urethral reconstruction (experiment on rabbit)
Authors: Hariastawa IGB Adria , Rantam Fedik A. , Hardjowijoto Sunaryo 
Published: March 2020

ABSTRACT

Background:
Urethral reconstruction has been a problem for a long time and is a major challenge for surgeons. Surgical management of urethral defects is still controversial because there is no synthetic material that is considered ideal as a substitute for the urethra. With the development of adipose-derived mesenchymal stem cells, this research aims to observe the difference between the use of dried amniotic membrane as a scaffold with and without mesenchymal stem cells seeding as graft in urethral reconstruction.

Methods:
This research was a pure experimental research with a post-test only control group design using 24 male New Zealand white rabbits. The samples were divided into 3 groups: one control group, one scaffold (dried amniotic membrane) without stem cell seeding group, and one stem cell-seeded scaffold group. The rabbits were evaluated at 28 days after treatment and the results were analyzed using Chi-Square test.

Results:
The number of urethras that were healed were higher in stem cell-seeded scaffold compared to scaffold without stem cell seeding group (p < 0.05).

Conclusion:
Considering the promising result, application of dried amniotic membrane as a scaffold with adipose-derived mesenchymal stem cell seeding could be an option for urethral reconstruction.

Highlights:
Transitions of Students with Autism and Intellectual Disabilities in Inclusive Settings: The Nexus Between Recommended and Actual Practice
Authors: Cumming Therese M. , Strnadová Iva , Danker Joanne 
Published: March 2020

AbstractStudents with autism and intellectual disabilities experience many transitions during their schooling, and a large body of literature is devoted to best practices in transition planning and support. The Taxonomy for Transition Programming 2.0 is a research-based model that provides best practice suggestions to guide the planning of various transitions and contexts. The researchers aimed to use the current qualitative study to discover the transition planning practices used to support students with autism and intellectual disabilities in inclusive school settings when transitioning from primary to secondary schools and from secondary school to postschool life in New South Wales (Australia). The practices that emerged were then examined for alignment with the Taxonomy for Transition Programming 2.0. The inductive content analysis of interviews with 8 parents and 13 teachers indicated that although most of the areas of the Taxonomy are represented in the planning processes, there is room for improvement, particularly in the areas of formal individual education program and transition planning, student involvement, information sharing, and program assessment. The results highlighted the importance of formal student- and family-centred planning processes to the success of both transitions. The results were used to make further recommendations for future research, policy, and practice.
Phase portraits of the quadratic polynomial Liénard differential systems
Authors: Gouveia Márcio R. A. , Llibre Jaume , Roberto Luci Any 
Published: March 2020

AbstractWe classify the global phase portraits in the Poincaré disc of the quadratic polynomial Liénard differential systems
\dot{x}=y, \quad \dot{y}=(ax+b)y+cx^2+dx+e,where (x, y) ∈ ℝ2 are the variables and a,b,c,d,e are real parameters.
Multiple bound states of higher topological type for semi-classical Choquard equations
Authors: Liu Xiaonan , Ma Shiwang , Xia Jiankang 
Published: March 2020

AbstractWe are concerned with the semi-classical states for the Choquard equation$$-{\epsilon }^2\Delta v + Vv = {\epsilon }^{-\alpha }(I_\alpha *|v|^p)|v|^{p-2}v,\quad v\in H^1({\mathbb R}^N),$$whereN⩾ 2,Iαis the Riesz potential with order α ∈ (0,N− 1) and 2 ⩽p< (N+ α)/(N− 2). When the potentialVis assumed to be bounded and bounded away from zero, we construct a family of localized bound states of higher topological type that concentrate around the local minimum points of the potentialVas ε → 0. These solutions are obtained by combining the Byeon–Wang's penalization approach and the classical symmetric mountain pass theorem.
Homocysteine, the methylenetetrahydrofolate reductase 677C>T polymorphism and hypertension: effect modifiers by lifestyle factors and population subgroups
Authors: Ornosa-Martín Gemma , Fernandez-Ballart Joan D. , Ceruelo Santiago , Ríos Lídia , Ueland Per M. , Meyer Klaus , Murphy Michelle M. 
Published: March 2020

AbstractEvidence linking fasting plasma total homocysteine (tHcy) and methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype with hypertension is inconsistent. Differences in B vitamin status, other lifestyle factors or their consideration in analyses might explain this. We investigated these associations in the absence of mandatory fortification with folic acid and B vitamin supplement use. A cross-sectional study was conducted in 788 adults, aged 18–75 years, randomly selected from three Catalonian town population registers. Fasting plasma folate, cobalamin, tHcy, erythrocyte folate, erythrocyte glutathione reductase activation coefficient (EGRAC, functional riboflavin status indicator; increasing EGRAC indicates worsening riboflavin status), MTHFR 677C>T and solute carrier family 1 (SLC19A1) 80 G>A genotypes were determined. Medical history and lifestyle habits were recorded. Principal tHcy determinants differed between women (age, plasma folate, plasma cobalamin, cigarettes/d) and men (MTHFR 677TT genotype, plasma folate, plasma cobalamin and CT genotype). The MTHFR 677C>T polymorphism–tHcy association (β standardised regression coefficients) was stronger in male smokers (0·52, P < 0·001) compared with non-smokers (0·21, P = 0·001) and weaker in participants aged >50 years (0·19, P = 0·007) compared with ≤50 years (0·31, P < 0·001). Hypertension was more probable in the third tHcy tertile compared with other tertiles (OR 1·9; 95 % CI 1·2, 3·0), and in participants aged ≤50 years, for the MTHFR 677TT genotype compared with the CC genotype (OR 4·1; 95 % CI 1·0, 16·9). EGRAC was associated with increased probability of hypertension in participants aged >50 years (OR 6·2; 95 % CI 1·0, 38·7). In conclusion, moderately elevated tHcy and the MTHFR 677CT genotype were associated with hypertension. The MTHFR 677C>T genotype–hypertension association was confined to adults aged ≤50 years.
The CMT Model of Free Will
Authors: Vervoort Louis , Blusiewicz Tomasz 
Published: March 2020

ABSTRACTWe propose a compatibilist theory of free will in the tradition of naturalized philosophy that attempts to: 1) provide a synthesis of a variety of well-known theories, capable of addressing problems of the latter; 2) account for the fact that free will comes in degrees; and 3) interface with neurobiology. We argue that free will comes in degrees, and that these degrees vary with the agent's capacity to make assumptions and use theories. Our model, then, highlights that free-willed actions are consciously monitored by the agent, through beliefs, assumptions, and ultimately theories — hence, the CMT model (for Conscious-through-Monitoring-through-Theories).
“IT'S TOO MUCH!”: VICTIMS OF GENDER-BASED VIOLENCE ENCOUNTER THE MOROCCAN STATE
Authors: Žvan Elliott Katja 
Published: March 2020

AbstractBy using the narrative approach and linking it to feminist research ethics and critical race methodology, this article seeks to understand how non-literacy and poverty hinder low-income women's access to justice and how these women experience the Moroccan state. The state here acts as an oppressive and marginalizing entity in women's lives, but also offers the potential for empowerment. This ethnographic study tells the stories of three victims of gender-based violence to demonstrate that the state needs to (1) set up an efficient and responsive infrastructure for those lacking know-how and money; (2) institute proper training of state agents for implementation of laws and to prevent them from acting on personal opinions and attitudes with regard to women's rights; and (3) strengthen procedures so that state agents can respond expeditiously to the needs and grievances of citizens.
Families, Manumission, and Freed People in Urban Minas Gerais in the Era of Atlantic Abolitionism
Authors: Dantas Mariana L.R. , Libby Douglas C. 
Published: March 2020

AbstractLate eighteenth- and early nineteenth-century Minas Gerais was heavily reliant on its slave labor force and invested in the social order shaped by slavery. The main systematic challenge to slavery was discrete negotiations of manumission that resulted in the freedom of a few individual slaves. This practice fueled the expansion of a free population of African descendants, who congregated most visibly in the captaincy's urban centers. Through an examination of manumission stories from two African-descendant families in the towns of Sabará and São José, this article underscores the relevance of family ties and social networks to the pursuit and experience of freedom in the region. As slavery remained entrenched in Brazil, despite Atlantic abolitionist efforts elsewhere, urban families’ pursuit and negotiation of manumissions shaped a historical process that naturalized the idea and possibility of black freedom.
Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel
Authors: Abou-El-Naga Iman F. 
Published: March 2020

AbstractSchistosoma mansoni is the most common species causing schistosomiasis. It has a complex life cycle involving a vertebrate definitive host and a snail intermediate host of the genus Biomphalaria. Each stage encounters a plethora of environmental stresses specially heat stress. Another sort of stress arises from repeated exposure of the parasite to praziquantel (PZQ), the only drug used for treatment, which leads to the development of resistance in the fields and the labs. Heat shock protein 70 (Hsp70) is found in different developmental stages of S. mansoni. It is immunogenic and regulate cercarial invasion besides its chaperone function. In the Biomphalaria/S. mansoni interaction, epigenetic modulations of the Hsp70 gene underscore the susceptibility phenotype of the snail. Hsp70 is up-regulated in adult S. mansoni with decreased sensitivity to PZQ. This could be due to the induction of oxidative and endoplasmic reticulum stress, induction of apoptosis, exposure to the stressful drug pressure and increase influx of calcium ions. Up-regulation of Hsp70 might help the worm to survive the schistosomicidal effect of the drug mainly by dealing with misfolded proteins, inhibition of apoptosis, induction of autophagy, up-regulation of the P-glycoprotein transporter and attenuation of the signalling from G protein coupled receptors.
Monorchis parvusandGymnophallus choledochus: two trematode species infecting cockles as first and second intermediate host
Authors: Magalhães Luísa , Daffe Guillemine , Freitas Rosa , de Montaudouin Xavier 
Published: March 2020

AbstractThe most deleterious stage of a trematode life cycle occurs in the first intermediate host where the parasite penetrates as a miracidium and asexually multiplicates in sporocysts or rediae. When infection advances, other organs can be occupied with severe effects on host individual health and population dynamics. Existing studies focused on these host/parasite systems are still scarce due to the usual low prevalence in ecosystems. Using cockles (Cerastodermaspp.) and two trematode species (Monorchis parvusandGymnophallus choledochus) infecting these bivalves as first and second intermediate host, the present work aimed to (1) summarize the most relevant literature and (2) provide new information regarding this host/parasite system, taking advantage of a 21-year monthly database from Banc d'Arguin (France). This long-term monitoring showed that different trematode species display varying host size range preference (6–38 and 31–36 mm forM. parvusandG. choledochus, respectively). The occurrence of coinfection was lower than expected, raising some questions related to parasite interspecific competition. This review improved our understanding of the processes shaping the prevalence and distribution of parasitism. This study highlighted that beyond constant trematode assemblage monitoring, there is a need to identify the main predictors of rediae/sporocysts infection, such as the definitive host dynamics and miracidium infection processes, for future better management of host severe disease and mortality episodes.
Moshpit Medicine: The Experience of an Australian Event Resuscitation Team
Authors: Wing Sean , Johnson Robert , Fowler Leigh 
Published: March 2020

AbstractThe authors reviewed case reports of patients presenting to an advanced medical assessment and resuscitation service at 15 music events over 22 days from June 2018 through March 2019 around Australia. Event size ranged from 4,000 to 57,500 participants. Events observed had a mean patient presentation rate (PPR) of 0.83% (SD = 0.59%) and mean transport to hospital rate (TTHR) of 1.89 (SD = 0.92) per 10,000. Two-hundred and twenty-one cases were reviewed and tabulated for descriptive analysis.Lower rates of traumatic injuries were seen compared to other case reports, and minor procedures represented a minor but important part of the team’s workload. Methylenedioxymethamphetamine (MDMA) use was reported by 33.0% of patients on the day of presentation; almost one-half of these reported a co-ingestion. Patients presenting after using MDMA were more likely to have an elevated temperature. Eight percent of patients presented with temperature above 38°C. Patients with an initial temperature above 38°C were more likely to require hospitalization. On-site electrocardiograph (ECG), blood gas, ultrasound, and urinalysis were found to be useful in decision support. In total, 29.8% of patients required sedation during their encounter; 2.7% required rapid sequence induction at the event. Mean observation time was 44 minutes, with longer observation required in MDMA and hallucinogen-related presentations.
Patients’ quality of life: Validation of the functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) instrument for the Mexican population
Authors: Rivera-Fong Liliana , Benjet Corina , Robles García Rebeca , Traeger Lara , Aguilar Ponce José Luis , Valero Saldaña Luis Manuel , Acosta Maldonado Brenda Lizeth , Rivas Vera Silvia , Galindo Vázquez Oscar , Riveros Rosas Angélica 
Published: March 2020

AbstractObjectiveThe functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) is a widely used instrument to assess quality of life (QOL) in hematopoietic stem cell transplant (HSCT) patients, but there is little evidence of its validity in Latin American populations. This study evaluated the psychometric properties of the Spanish language version of the FACT-BMT in Mexican patients.MethodFirst, the original version was piloted with 15 HSCT patients to obtain an adequate cultural version, resulting in the adaptation of one item. After that, the new version was completed by 139 HSCT patients.ResultsThe results showed a FACT factor structure that explains 70.84% of the total variance, a factor structure similar to the original FACT structure, and with a high internal consistency (Cronbach's alpha = 0.867). For the BMT subscale, the best factor structure included 17 items which explain 61.65% of the total variance with an adequate internal consistency (Cronbach's alpha = 0.696).Significance of the resultsThe FACT-BMT was found to be a valid and reliable instrument to evaluate QOL in Mexican patients. Our results constitute new FACT-BMT empirical evidence that supports its clinical and research uses.
What is a career politician? Theories, concepts, and measures
Authors: Allen Nicholas , Magni Gabriele , Searing Donald , Warncke Philip 
Published: March 2020

AbstractThis paper examines the concept “career politician.” It seeks to clarify, systematize, and measure this ambiguous multidimensional concept in order to facilitate testing theories and hypotheses associated with it. We argue that career politicians are full-time politicians who lack significant experience in the wider world and have other distinguishing attributes for which they are both appreciated and criticized. From claims and critiques put forward by political scientists, journalists, publics, and politicians, we extract four principal dimensions: Strong Commitment, Narrow Occupational Background, Narrow Life Experience, and Strong Ambition. These dimensions and their indicators fit Wittgenstein’s family-resemblance conceptual structure, which is how we analyze, measure and validate them with data from a longitudinal study of British MPs spanning 1971–2016.
Dust Devils on Titan
Authors: Jackson Brian , Lorenz Ralph D. , Barnes Jason W. , Szurgot Michelle 
Published: March 2020

AbstractConditions on Saturn's moon Titan suggest that dust devils, which are convective, dust‐laden plumes, may be active. Although the exact nature of dust on Titan is unclear, previous observations confirm an active aeolian cycle, and dust devils may play an important role in Titan's aeolian cycle, possibly contributing to regional transport of dust and even production of sand grains. The Dragonfly mission to Titan will document dust devil and convective vortex activity and thereby provide a new window into these features, and our analysis shows that associated winds are likely to be modest and pose no hazard to the mission.
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure
Authors: Dickstein Dara L. , De Gasperi Rita , Gama Sosa Miguel A. , Perez-Garcia Georgina , Short Jennifer A. , Sosa Heidi , Perez Gissel M. , Tschiffely Anna E. , Dams-O’Connor Kristen , Pullman Mariel Y. , Knesaurek Karin , Knutsen Andrew , Pham Dzung L. , Soleimani Lale , Jordan Barry D. , Gordon Wayne A. , Delman Bradley N. , Shumyatsky Gleb , Shahim Pashtun-Poh , DeKosky Steven T. , Stone James R. , Peskind Elaine , Blennow Kaj , Zetterberg Henrik , Chance Steven A. , Torso Mario , Kostakoglu Lale , Sano Mary , Hof Patrick R. , Ahlers Stephen T. , Gandy Sam , Elder Gregory A. 
Published: March 2020

AbstractTraumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [18F]AV1451 (flortaucipir) tau ligand, we found that five of 10 veterans exhibited excessive retention of [18F]AV1451 at the white/gray matter junction in frontal, parietal, and temporal brain regions, a typical localization of CTE tauopathy. We also observed elevated levels of neurofilament light (NfL) chain protein in the plasma of veterans displaying excess [18F]AV1451 retention. These findings suggest an association linking blast injury, tauopathy, and neuronal injury. Further study is required to determine whether clinical, neuroimaging, and/or fluid biomarker signatures can improve the diagnosis of long-term neuropsychiatric sequelae of mTBI.
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices
Authors: Wu Yuanhao , Okesola Babatunde O. , Xu Jing , Korotkin Ivan , Berardo Alice , Corridori Ilaria , di Brocchetti Francesco Luigi Pellerej , Kanczler Janos , Feng Jingyu , Li Weiqi , Shi Yejiao , Farafonov Vladimir , Wang Yiqiang , Thompson Rebecca F. , Titirici Maria-Magdalena , Nerukh Dmitry , Karabasov Sergey , Oreffo Richard O. C. , Carlos Rodriguez-Cabello Jose , Vozzi Giovanni , Azevedo Helena S. , Pugno Nicola M. , Wang Wen , Mata Alvaro 
Published: March 2020

AbstractSupramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into functional materials and devices. Harnessing the inherent properties of both disordered proteins and graphene oxide (GO), we report a disordered protein-GO co-assembling system that through a diffusion-reaction process and disorder-to-order transitions generates hierarchically organized materials that exhibit high stability and access to non-equilibrium on demand. We use experimental approaches and molecular dynamics simulations to describe the underlying molecular mechanism of formation and establish key rules for its design and regulation. Through rapid prototyping techniques, we demonstrate the system’s capacity to be controlled with spatio-temporal precision into well-defined capillary-like fluidic microstructures with a high level of biocompatibility and, importantly, the capacity to withstand flow. Our study presents an innovative approach to transform rational supramolecular design into functional engineering with potential widespread use in microfluidic systems and organ-on-a-chip platforms.