bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Discovery of G-Quadruplexes in Wheat: Distribution and Putative Functional Roles
Authors: Cagirici H Busra , Sen Taner Z 
Published: April 2020

Abstract
G-quadruplexes are nucleic acid secondary structures formed by a stack of square planar G-quartets. G-quadruplexes were implicated in many biological functions including telomere maintenance, replication, transcription, and translation, in many species including humans and plants. For wheat, however, though it is one of the world’s most important staple food, no G-quadruplex studies have been reported to date. Here, we computationally identify putative G4 structures (G4s) in wheat genome for the first time and compare its distribution across the genome against five other genomes (human, maize, Arabidopsis, rice, and sorghum). We identified close to 1 million G4 motifs with a density of 76 G4s/Mb across the whole genome and 93 G4s/Mb over genic regions. Remarkably, G4s were enriched around three regions, two located on the antisense and one on the sense strand at the following positions: 1) the transcription start site (TSS) (antisense), 2) the first coding domain sequence (CDS) (antisense), and 3) the start codon (sense). Functional enrichment analysis revealed that the gene models containing G4 motifs within these peaks were associated with specific gene ontology (GO) terms, such as developmental process, localization, and cellular component organization or biogenesis. We investigated genes encoding MADS-box transcription factors and showed examples of G4 motifs within critical regulatory regions in the VRN-1 genes in wheat. Furthermore, comparison with other plants showed that monocots share a similar distribution of G4s, but Arabidopsis shows a unique G4 distribution. Our study shows for the first time the prevalence and possible functional roles of G4s in wheat.
Factualidad e imparcialidad informativa en la prensa digital publicada durante la campaña presidencial en Colombia, 2014 -2018
Authors: García-Arango Ximena 
Published: April 2020

En este artículo se describe y analizan los contenidos publicados en los medios de comunicación en la web durante las campañas presidenciales de Colombia de 2014, para identificar la imparcialidad y la factualidad informativa en la prensa digital. Se sustenta en el método interpretativo – hermenéutico, mediante el estudio de caso y análisis de contenido de los artículos web publicados entre el 25 de mayo y el 15 de junio de 2014 por los periódicos El Tiempo y El Espectador. Dentro de los hallazgos se identificó: el uso de una única fuente informativa y la limitación de testimonios a opiniones personales de políticos; priorización a contenidos sobre políticos y eventos de campaña por encima de análisis y programas de gobierno; los temas de paz y apoyo para la reelección presidencial fueron relevantes. Se concluye que el relato discursivo de ambos medios, redujo la narrativa escrita y le dio prioridad al uso de imágenes y videos, estableciendo una noticia que, si bien amplía los formatos en capacidad informativa, simplifica y modifica los elementos informativos relacionados con el hecho-suceso.
The orchids of John Henry Lance (1793–1878)
Authors: Ossenbach Carlos 
Published: April 2020

John Henry Lance, a British barrister, spent a ten-year term in Surinam as Judge appointed to the ‘Mixed Court’ in Paramaribo, a post created to supervise the compliance of the Dutch authorities with a treaty signed between the Netherlands and England in 1818 prohibiting the slave trade in the Dutch colonies. During his term in Paramaribo, Lance, a friend of Bateman and Lindley, collected several new orchid species. However, his collection of watercolors depicting plants from Surinam, many of them orchids, would appear to be more important. Some of these were painted by himself, others by the Surinamese artist Gerrit Schouten. The orchids of this collection, never published, were supplied by the Lindley Library of the R.H.S. and are reproduced here with its kind permission.
Key Words: botanical illustration, history of botany, Orchidaceae, Surinam
Academia, Estado y Activismo Femenino
Authors: Tubay Zambrano Fanny , Sant'ana Helena 
Published: April 2020

Este trabajo examina aspectos del tejido social en Portugal, a partir de una cooperación interdisciplinar entre la academia, el estado y el activismo femenino, logrando articular sus objetivos desde una perspectiva de género con miras a alcanzar una educación para la igualdad. Los resultados vislumbran una academia que propicia un encuadre científico que reconoce la diversidad sin negar las diferencias; un estado que aborda cuestiones educativas y sociales como ejes prioritarios y por otro lado la participación de grupos de activismo femenino que a través de una praxis ciudadana propician un debate más cercano y honesto dentro del campo de los estudios de género. Se aplica una metodología experimental y de observación participante ejecutada durante una estancia doctoral cuyo enfoque intercultural se plantea como herramienta de aprendizaje colaborativo. La triangulación social refleja en esta investigación un trabajo que visibiliza y da voz a grupos diversos que promueven la participación ciudadana.
Palabras claves: Academia, estado, activismo, ciudadanía, género.
A Plan for a Long-Term, Automated, Broadband Seismic Monitoring Network on the Global Seafloor
Authors: Kohler Monica D. , Hafner Katrin , Park Jeffrey , Irving Jessica C. E. , Caplan-Auerbach Jackie , Collins John , Berger Jonathan , Tréhu Anne M. , Romanowicz Barbara , Woodward Robert L. 
Published: April 2020

AbstractEstablishing an extensive and highly durable, long-term, seafloor network of autonomous broadband seismic stations to complement the land-based Global Seismographic Network has been a goal of seismologists for decades. Seismic signals, chiefly the vibrations from earthquakes but also signals generated by storms and other environmental processes, have been processed from land-based seismic stations to build intriguing but incomplete images of the Earth’s interior. Seismologists have mapped structures such as tectonic plates and other crustal remnants sinking deep into the mantle to obtain information on their chemical composition and physical state; but resolution of these structures from land stations is not globally uniform. Because the global surface is two-thirds ocean, increasing the number of seismic stations located in the oceans is critical for better resolution of the Earth’s interior and tectonic structures. A recommendation for a long-term seafloor seismic station pilot experiment is presented here. The overarching instrumentation goal of a pilot experiment is performance that will lead to the installation of a large number of long-term autonomous ocean-bottom seismic stations. The payoff of a network of stations separated from one another by a few hundred kilometers under the global oceans would be greatly refined resolution of the Earth’s interior at all depths. A second prime result would be enriched understanding of large-earthquake rupture processes in both oceanic and continental plates. The experiment would take advantage of newly available technologies such as robotic wave gliders that put an affordable autonomous prototype within reach. These technologies would allow data to be relayed to satellites from seismometers that are deployed on the seafloor with long-lasting, rechargeable batteries. Two regions are presented as promising arenas for such a prototype seafloor seismic station. One site is the central North Atlantic Ocean, and the other high-interest locale is the central South Pacific Ocean.
Prescription audit of rheumatoid arthritis patients treated at primary and secondary care level, before reaching a tertiary care centre hospital in Eastern India
Authors: Mukherjee Dibyendu , Nandi Suman , Chaudhuri Soumyabrata Roy , Patra Sucharita , Roy Mithun 
Published: April 2020

Background: To analyse the usage pattern of pharmacological agents in the treatment of rheumatoid arthritis in Eastern India at a community level before reaching a specialized rheumatology clinic.Methods: Total 200 patients earlier diagnosed to be RA on treatment were selected and their demographic details, duration of treatment, agents prescribed, adverse drug reactions (ADRs) were analysed.Results: At the end of the study analysis, we observed that HCQ (24.4%) and Sulphasalazine (20.9%) were the commonest disease modifying anti-rheumatoid drug (csDMARD) used, followed by Methotrexate (16.9%). Dual combination csDMARD (33.1%) was preferred. Biological therapy was a rarity (0.5%). Steroids (21.0%) and NSAIDs (22.5%) was commonly used. Complementary and Alternative Medicines (CAM) (44.0%) was used often. Polypharmacy was the trend. Not all patients diagnosed as RA met the 2010 ACR/EULAR classification criteria of RA.Conclusions: In 15% patients, the diagnosis of RA was inappropriate according to the recent classification criteria. csDMARD was preferred either as monotherapy or combination therapy. Use of steroids and NSAID was a common practice. ADR were mild in severity.
Acerca de la doble publicación y el cumplimiento de otros requisitos para el envío de manuscritos a la Revista Colombiana de Obstetricia y Ginecología
Authors: Gaitán Hernando 
Published: April 2020

Hace ocho años, la Revista Colombiana de Obstetricia y Ginecología inició un proceso de mejoramiento de la calidad científica y editorial, que ha incluido tener un claro proceso de revisión por pares, con tiempos definidos de evaluación y publicación final, presentación delos resúmenes en español e inglés, y en algunos casos publicación de artículos completos en idiomas diferentes al español, idioma oficial de la revista. Las palabras clave en español son homologadas con los descriptores en ciencias de la salud (DeCS) y las palabras clave en inglés con los términos de encabezamiento médico (MeSh), y todos los artículos son sometidos a un riguroso proceso de edición final.
Maarif Salnamelerine Göre Menteşe Sancağında Eğitim-Öğretim (1898-1904)
Authors: VURGUN Ahmet 
Published: April 2020

II. Abdülhamid döneminde
modern eğitim sistemi ve kurumlarının gelişimi hız kazanarak tüm ülke çapında
yayılmaya başlamıştır. Diğer yandan yapılan bu faaliyetleri ve ülkedeki
eğitimin mevcut durumunu ortaya koyan yayınlar da hazırlanmıştır. Bu dönemde
eğitimde ilgili hazırlanan çalışmalardan başlıcasını Maarif Salnameleri
oluşturur.

Bu araştırmada, Maarif Salnamelerindeki
bilgilerden hareketle Menteşe Sancağında bulunan geleneksel eğitim kurumu medreselerle
birlikte modern eğitim kurumları olan; ibtidailer, rüşdiyeler, idadi ile gayrimüslimlerin okulları incelenmiştir.
Bu bağlamda mevcut okulların idari ve öğretim kadrosu, dersleri, okulların
açılış tarihi hakkında bilgi verilmiştir. Ayrıca eğitim-öğretim faaliyetlerinin
ayrılmaz bir bütünü olan ve Menteşe’de bulunan kütüphaneler ve kitap sayıları
ile Menteşe Sancağının 19. yüzyılın sonundan 20. yüzyılın başına eğitim durumu
tespit edilmeye çalışılmıştır.
Stress-related coping styles in myalgic university students: A case control study.
Authors: Soto-Goñi Xabier , Viñals Ana Cristina , Pérez-González Fabian , Sánchez-Labrador Luis , Domínguez-Gordillo Adelaida , Sánchez-Sánchez Teresa , Ardizone-García Ignacio , Jiménez-Ortega Laura 
Published: April 2020

Abstract
Background: Patients suffering pain-related temporomandibular disorders (TMD) exhibit greater levels of psychological distress, environmental stress, somatic symptoms, anxiety, depression, somatic awareness, pain catastrophizing, and impaired pain coping strategies compared to pain-free controls. However, little is known about psychological factors involved in the different TMD types fulfilling DC/TMD criteria. Furthermore, regardless of severity, the role of general coping strategies and styles in TMD is not yet well understood. The main goal of this study was to investigate stress-related coping styles, anxiety and personality traits in a group of dentistry students suffering from temporomandibular disorder with myalgia. Methods: A cohort of 102 university students was initially recruited for this study. Following clinical evaluation, a myalgia group (24 participants) and a control group (25 participants) were formed. Participants were later assessed in anxiety, stress coping strategies, and personality measures by using the State-trait anxiety inventory (STAI), coping response inventory (CRI), and Neo Five-Factor Inventory (NEO-FFI) questionnaires respectively.Results: The myalgia group presented greater levels of trait anxiety and neuroticism in comparison to the control group. Participants with myalgia also showed higher levels of avoidance coping which was the only reliable predictor of TMD. Conclusions: Avoidance coping strategies are generally considered maladaptive, as they seem to increase perceived stress, a robust predictor of TMD. Interventions aimed at reducing stress and anxiety levels, increase emotional stability, and preventing maladaptive coping styles, might improve temporomandibular health and prevent the myalgia and its chronification.
The impact of community-based health promotion on quality of life: The need to control for general health trends. The Northern Sweden MONICA Study in 2014
Authors: Spegel Elin , Ek Kristina , Söderberg Stefan , Eliasson Mats 
Published: April 2020

Abstract
Background: The Västerbotten Intervention Programme (VIP) is a public health promotion programme in northern Sweden aimed at preventing cardiovascular diseases. Its positive effects on disease risk factors and on the risk of coronary heart disease itself have been reported, although the evidence is not unequivocal. Since only historical controls have been used, effects from sources other than the programme have largely been uncontrolled for and health-related quality of life (QoL) has not been evaluated.Methods: By using the neighbouring county of Norrbotten (NB) as a reference population, we compare QoL in Västerbotten (VB) and NB. In 2014, the World Health Organization’s Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Study was implemented in northern Sweden, where random samples from VB and NB were examined. In total, 1112 participants between the ages of 40 to 74 participated: 516 in VB, and 594 in NB. Their QoL was measured with the three-level EuroQol 5-dimension (EQ-5D-3L) questionnaire. Differences in mean QoL between VB and NB were analysed via the Student’s t-test and the Pearson chi-square test.Results: Average QoL measured by the EQ-5D index was 0.798 in VB and 0.811 in NB, i.e. a difference of 0.013 (p = 0.2; confidence interval/CI -0.009 to 0.036). For participants aged 45–54, the QoL was lower in VB than in NB, showing a difference of 0.048 (p = 0.041; CI 0.002 to 0.0094). In NB, QoL decreased with age – a pattern not seen in VB. Men had higher QoL than women, and participants with a university education had higher QoL than those without one. The vertical visual analogue scale (EQ VAS) showed similar results. Participants from NB and from VB did not differ regarding age, gender or level of education.Conclusions: We found similar levels of health-related QoL in VB and NB.Trial registration: Not applicable
COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation
Authors: Jiang Ya , Bai Xue , Li Ting-Ting , Hawwas Mohammed AL , Jin Yuan , Zou Yu , Hu Yue , Liu Lin-Yi , Zhang Ying , Liu Qing , Yang Hao , Ma Jun , Wang Tinghua , Liu Jia , Xiong Liu-Lin 
Published: April 2020

Abstract
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This study was conducted to determine the specific potential molecular mechanism in the hypoxic-ischemic induced cerebral injury.Methods: Here, hypoxic-ischemic (HI) animal models were established and primary cortical neurons were subjected to oxygen-glucose deprivation (OGD) to mimic HIE model in-vivo and in-vitro. The HI-induced neurological injury was evaluated by Zea-longa scores, Triphenyte-trazoliumchloride (TTC) staining the Terminal Deoxynucleotidyl Transferased Utp Nick End Labeling (TUNEL) and immunofluorescent staining. Then the expression of Cytochrome c oxidase subunit 5a (COX5A) was determined by immunohistochemistry, western blotting (WB) and quantitative real time Polymerase Chain Reaction (qRT-PCR) techniques. Moreover, HSV-mediated COX5A over-expression virus was transducted into OGD neurons to explore the role of COX5A in-vitro, and the underlying mechanism was predicted by GeneMANIA, then verified by WB and qRT-PCR. Results: HI induced a severe neurological dysfunction, brain infarction, and cell apoptosis as well as obvious neuron loss in neonatal rats, in corresponding to the decrease on the expression of COX5A in both sides of the brain. What’s more, COX5A over-expression significantly promoted the neuronal survival, reduced the apoptosis rate, and markedly increased the neurites length after OGD. Moreover, Triosephosephate isomerase (TPI) was predicted as physical interactions with COX5A, and COX5A over-expression largely increased the expressional level of TPI. Conclusions: The present findings suggest that COX5A plays an important role in promoting neurological recovery after HI, and this process is related to TPI up-regulation.
The prediction and risk point score (RPS) of high frequency hearing loss in noise exposed workers
Authors: Sun Ruican , Shang Weiwei , Cao Yingqiong , Lan Yajia 
Published: April 2020

Abstract
Background: Occupational hearing loss is a significant occupational health concern in many countries, and high frequency hearing loss (HFHL) is an early symptom. Based on realistic demands, we aimed to build a prediction risk model of HFHL and developed the related risk point score (RPS). The results of this study are expected to provide technological support for interventions and management to enhance application-oriented research of HFHL.Methods: A total of 32121 participants who were noise exposed workers were enrolled. The datasets from the National key occupational diseases survey (NKODS) performed from 2014 to 2017 in Sichuan Province in China were utilized. The sociodemographic and occupational characteristics were assessed by standardized questionnaires, and the level of HFHL were collected by audiometric testing and was defined as a binaural high frequency threshold average (BHFTA) over 40 dB in the right and left ears. The risk prediction models were generated by linear logistic regression, and based on the models, the risk point score (RPS) of HFHL were calculated. Results: Of the 32121 participants in the study, 9.97% (n=4029) of workers had HFHL (BHFTA ≥ 40 dB). Age (OR=1.08, 95% CI: 1.071–1.083), sex (OR=3.34, 95% CI: 2.880–3.636), noise exposure time (OR=1.01, 95% CI: 1.008–1.018), manufacturing industry (OR=1.46, 95% CI: 1.302–1.647), construction industry (OR=2.14, 95% CI: 1.488–3.069), mining industry (OR=2.57, 95% CI: 2.225–2.957), foreign enterprise (OR=0.94, 95% CI: 0.781–1.122), and private enterprise (OR=1.32, 95% CI: 1.200–1.442) were predictors of HFHL (P<0.05). By comparing the two risk prediction models, the 40 dB HL criterion model was found to be more effective than the 25 dB HL criterion model (AUC=0.637). Verification of the two models revealed that the 25 dB HL criterion model was more stable than the 40 dB HL criterion.Conclusion: The study found that the prevalence of HFHL was moderate in Sichuan Province. Sex, age, noise exposure years, and employment in the manufacturing industry, construction industry, mining industry, foreign enterprise, or private enterprise were predictors of HFHL, and the development of the RPS of HFHL is necessary for application-oriented research on HFHL.
Characterization of an H6N1 avian influenza virus from an illegally imported product
Authors: wang yan , jiang ming wen , li ping jin , zhang ping lei , zhang qiang , li yang chun 
Published: April 2020

Abstract
Background : H6N1 is low pathogenic virus commonly found in wild and domestic birds across many continents. To investigate the infective status of imported food, we detected avian influenza virus (AIV) in illegally imported frozen food from international flight. Methods : The virus was isolated, the complete genome was sequenced, and the pathogenicity was tested. PQIATR/G was found in the motif of the HA cleavage site of the isolated strain, which conforms to the molecular characteristics of a low pathogenic AIV. The amino acid residues at positions 186, 190, 226, and 228 of the HA protein receptor binding sites were proline (P), valine (V), glutamine (Q), serine (S), respectively, exhibiting the molecular characteristics required to bind to human-like receptors. The SPF chicken test showed that the IVPI was 0 and the virus was a low pathogenic AIV. The infectious results in BALB/c mice showed that the isolate could be replicated in the lower respiratory tract of mice. Mice infected with a high dose of the virus displayed moderate weight loss but no obvious clinical symptoms. Results :The results of the sequence analysis showed that the avian influenza virus was of the H6N1 subtype, which shared the highest nucleotide identity with the AIV subtypes prevalent in Taiwan province. Conclusions : It is important to intensily monitor the illegal carrying.
Schizophrenia in The Context of Mental Health Services in Palestine: a literature review
Authors: Marie Mohammad , Shaabna Zareefa , Saleh Manahel 
Published: April 2020

Abstract
Background: Mental health conditions remain a significant cause of disability in the Arab World. Palestinians are predominantly at a higher risk for mental health problems due to their chronic exposure to political violence, prolonged displacement, and others as limited professional, educational, financial opportunities and mental health services. Schizophrenia is an overwhelming mental illness that affects nearly one percent of the various populations throughout the world. Studies have shown patients with schizophrenia die prematurely and have lower life expectancy compared to the general population. Moreover, antipsychotic medications and client’s lifestyle play a significant role in increased morbidity and mortality in these patients. The present study willingly undertakes a literature review on schizophrenia in the context of mental health services in Palestine.Methods: Studies were identified through PubMed, Science Direct, Google Scholar, CINAHL, Semantic Scholar and Elsevier.Results: Twenty-four studies were included in this review; eleven articles related to schizophrenia and thirteen articles related to mental health services in Westbank and Gaza. Results revealed the life of patients with schizophrenia in Palestine is complicated. Barriers as lacking awareness about mental illness, stigma, inconsistent availability of medications, absence of multidisciplinary teamwork, insufficient specialists, fragmented mental health system, occupation, and other obstacles stand in the face of improving the quality of life among these patients.Limitations: Palestine is a state that is seeking independence with a scarcity of resources. It has been described as “uncharted territories'' due to a lack of data, resources and records. As a result, there is insufficient data regarding schizophrenia in Palestine. Therefore, a thesis study that estimated Ten years’ risk of coronary heart diseases in patients with schizophrenia was included.Conclusions: Recommendations include ending the occupation as the leading cause of mental illness for Palestinians and implementing efficient and effective mental health nursing care through the multidisciplinary work and raising awareness regarding mental illness to fight the stigma.