bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental images, entrapment and affect in young adults meeting criteria of nonsuicidal self-injury disorder (NSSID) – a daily diary study
Authors: Cloos Marie , Di Simplicio Martina , Hammerle Florian , Steil Regina 
Published: February 2020

Abstract
Background
Incidents of nonsuicidal self-injury (NSSI) are often accompanied by mental images which could be perceived as distressing and/or soothing; yet existing data is derived from participants with a history of NSSI using retrospective methods. This study investigated mental images related to NSSI (“NSSI-images”), and their relationship to the proposed Nonsuicidal Self-Injury Disorder (NSSID).

Methods
An e-mail was sent to all female students of the local University providing the link to an online screening and 201 students with a history of repetitive NSSI responded. Nineteen eligible participants meeting criteria of NSSID (mean age = 25; 32% with migrant background) further completed a baseline interview and a ten-day-diary protocol.

Results
Among the sample of N = 201, 83.6% reported NSSI-images. In the subsample of n = 19 diagnosed with NSSID, the frequencies of NSSI and NSSI-images were correlated; about 80% of the most significant NSSI-images were either of NSSI or of an instrument associated with NSSI (i.e., a razorblade). In the diary, 53% of the sample self-injured. NSSI-images were reported on 94% of NSSI-days, and on days with NSSI and NSSI-images, the images almost always occurred first; the images were overall perceived as twice more distressing than comforting. Images on NSSI-days were characterized by more comfort, intrusiveness and compellingness yet less vividness, and increased subsequent positive and negative affect compared to non-NSSI days. NSSI-days were further marked by increased entrapment beliefs and increased negative yet decreased positive affect at night. These results were non-significant.

Limitations
Due to non-significant results among a small sample size and a low rate of NSSI among the NSSID-group, results remain preliminary.

Conclusions
The study provides information on feasibility and methodological challenges such as intervention effects of the diary. NSSI-images may be common among individuals who engage in NSSI; they may capture ambivalent (positive and negative) appraisals of NSSI and thus play a role in NSSI and possibly a disorder such as NSSID. The preoccupation with NSSI (Criterion C of NSSID in DSM-5) may as well be imagery-based.

Registration
The study was retrospectively registered with the DRKS under the number DRKS00011854.
Use of antidepressants and benzodiazepine-related hypnotics before and after initiation of TNF-α inhibitors or non-biological systemic treatment in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis
Authors: Brenner Philip , Citarella Anna , Wingård Louise , Sundström Anders 
Published: February 2020

Abstract
Background
Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are autoimmune disorders associated with an increased risk for depression, anxiety and sleeping problems. The objective of this study was to analyze use of antidepressants and benzodiazepine-related hypnotics (BRH) in Sweden before and after first time treatment with anti-TNF and non-biological systemic (NBS) treatments among patients with the above diagnoses, and to correlate such use with that of randomly selected population controls.

Methods
Patients and dispensed drugs were identified in nationwide Swedish healthcare registers. Proportions of subjects filling prescriptions of antidepressants and BRH from 2 years before start of treatment (index-date), and 2 years after index date were assessed. Using the period -6 months to index-date as reference, prevalence rate ratios were computed for 6 months’ intervals before and after index. For up to ten randomly selected population controls per patient, the same measures were calculated.

Results
A total of 6256 patients started anti-TNF treatment, and 13,241 NBS treatment. The mean age at index was 52.0 for the anti-TNF group and 56.1 for NBS. Use of antidepressants and BRH was similar in both treatment groups (10.4–12.8%), significantly more common than in the controls (6.6 to 7.6%). For all patients, proportions filling prescriptions for antidepressants and BRH decreased directly or soon after the index; no such changes were seen in the controls, who all showed a slow but steady increase in use over time. Starters of anti-TNF treatment did not show clearer decreases in use of psychotropics than those initiating NBS.

Conclusions
Decreased rates of dispensed psychotropic drugs after the time of anti-TNF and NBS treatment initiation were seen among patients with autoimmune disorders but not population controls. This may correspond to treatment effects of anti-TNF and NBS also on psychiatric symptoms among these patients.
Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing
Authors: Matsunami Kensaku , Sternal Fabian , Yaginuma Keita , Tanabe Shuichi , Nakagawa Hiroshi , Sugiyama Hirokazu 
Published: February 2020

AbstractThis paper presents a new method for process synthesis and economic assessment for solid drug product manufacturing, considering continuous manufacturing as a prominent process alternative. Of the three phases of drug development, phase II was targeted where the dosage form, formulation, and processing technology are determined. For a comprehensive alternative generation, a superstructure was developed that covered 9452 options for the unit level, which was combined with two options on the formulation strategy. The generated alternative was assessed by a net present value calculation model, which was adapted for dynamic cash flow consideration in the drug lifecycle. The model can incorporate uncertainty in the drug development and manufacturing in the result, and can perform global sensitivity analysis by Monte Carlo simulation. The method was demonstrated in a case study where two different scenarios regarding the price of the active pharmaceutical ingredient and the demand for the product were assumed. The results showed that when the demand and price are both low, the labor-related costs are dominant, and in the opposite case, the material-related costs become relevant. We also introduce the prototype version of the software “SoliDecision,” by which the presented method was implemented for industrial application.
Definition of the Churchill River Delta and its petroleum potential, offshore Labrador, Canada
Authors: Gillis Erin , Wright Richard , Mitchell Victoria , Montevecchi Nick 
Published: February 2020

Starting in 2011, a multiyear modern 2D long offset broadband seismic survey was acquired offshore Labrador, Canada, by TGS and PGS in partnership with Nalcor Energy. This regional survey covers the slope and deepwater portions of the margin. Three Mesozoic and Cenozoic-aged basins were informally defined from these data, the Chidley, Henley, and Holton; also, the poorly constrained Hawke Basin was remapped. The 2D data set imaged for the first time a very large Cenozoic-aged delta adjacent to the mouth of Lake Melville. We have mapped this delta on a [Formula: see text] 2D seismic grid. The delta is 5–8 km thick, and its aerial extent is [Formula: see text]. The age of this delta has been interpreted to be Eocene to Miocene. Adjacent to this Cenozoic delta on the Labrador shelf, there is a working petroleum system within the proximal Hopedale and Saglek Basins where there are five gas discoveries and one oil discovery. The modern long-offset 2D data set appears to indicate a working petroleum system within the newly mapped Cenozoic delta, and two phases of hydrocarbons may be present.
Osteoarthritis, Osteophytes, and Enthesophytes Affect Biomechanical Function in Adults With X-linked Hypophosphatemia
Authors: Steele Amy , Gonzalez Ramon , Garbalosa Juan C , Steigbigel Keith , Grgurich Tania , Parisi Erika J , Feinn Richard S , Tommasini Steven M , Macica Carolyn M 
Published: February 2020

Abstract

Context
X-Linked hypophosphatemia (XLH) is a lifelong metabolic disease with musculoskeletal comorbidities that dominate the adult clinical presentation.

Objective
The adult XLH disorder has yet to be quantified on the basis of the physical and functional limitations that can affect activities of daily living. Our goal was to report the impact of the musculoskeletal manifestations on physical function.

Design and setting
Musculoskeletal function was evaluated by validated questionnaires and in an interdisciplinary clinical space where participants underwent full-body radiologic imaging, goniometric range of motion (ROM) measurements, general performance tests, and kinematic gait analysis.

Patients
Nine adults younger than 60 years with a diagnosis of XLH and self-reported musculoskeletal disability, but able to independently ambulate, were selected to participate. Passive ROM and gait analysis were also performed on age-approximated controls to account for differences between individual laboratory instrumentation.

Results
Enthesophytes, degenerative arthritis, and osteophytes were found to be consistently bilateral and diffusely present at the spine and synovial joints across participants, with predominance at weight-bearing joints. Passive ROM in adults with XLH was decreased at the cervical spine, hip, knee, and ankle compared to controls. Gait analysis relative to controls revealed increased step width, markedly increased lateral trunk sway, and physical restriction at the hip, knees, and ankle joints that translated into limitations through the gait cycle.

Conclusions
The functional impact of XLH musculoskeletal comorbidities supports the necessity for creating an interprofessional health-care team with the goal of establishing a longitudinal plan of care that considers the manifestations of XLH across the lifespan.
Conditional Survival After Resection for Pancreatic Cancer: A Population-Based Study and Prediction Model
Authors:   for the Dutch Pancreatic Cancer Group, Latenstein Anouk E. J. , van Roessel Stijn , van der Geest Lydia G. M. , Bonsing Bert A. , Dejong Cornelis H. C. , Groot Koerkamp Bas , de Hingh Ignace H. J. T. , Homs Marjolein Y. V. , Klaase Joost M. , Lemmens Valery , Molenaar I. Quintus , Steyerberg Ewout W. , Stommel Martijn W. J. , Busch Olivier R. , van Eijck Casper H. J. , van Laarhoven Hanneke W. M. , Wilmink Johanna W. , Besselink Marc G. 
Published: February 2020

Abstract
Background
Conditional survival is the survival probability after already surviving a predefined time period. This may be informative during follow-up, especially when adjusted for tumor characteristics. Such prediction models for patients with resected pancreatic cancer are lacking and therefore conditional survival was assessed and a nomogram predicting 5-year survival at a predefined period after resection of pancreatic cancer was developed.

Methods
This population-based study included patients with resected pancreatic ductal adenocarcinoma from the Netherlands Cancer Registry (2005–2016). Conditional survival was calculated as the median, and the probability of surviving up to 8 years in patients who already survived 0–5 years after resection was calculated using the Kaplan–Meier method. A prediction model was constructed.

Results
Overall, 3082 patients were included, with a median age of 67 years. Median overall survival was 18 months (95% confidence interval 17–18 months), with a 5-year survival of 15%. The 1-year conditional survival (i.e. probability of surviving the next year) increased from 55 to 74 to 86% at 1, 3, and 5 years after surgery, respectively, while the median overall survival increased from 15 to 40 to 64 months at 1, 3, and 5 years after surgery, respectively. The prediction model demonstrated that the probability of achieving 5-year survival at 1 year after surgery varied from 1 to 58% depending on patient and tumor characteristics.

Conclusions
This population-based study showed that 1-year conditional survival was 55% 1 year after resection and 74% 3 years after resection in patients with pancreatic cancer. The prediction model is available via www.pancreascalculator.com to inform patients and caregivers.
Surgeons’ Ability to Predict the Extent of Surgery Prior to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy
Authors: Hentzen Judith E. K. R. , van der Plas Willemijn Y. , Been Lukas B. , Hoogwater Frederik J. H. , van Ginkel Robert J. , van Dam Gooitzen M. , Hemmer Patrick H. J. , Kruijff Schelto 
Published: February 2020

Abstract
Background
The extent of surgery (ES) during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) is a well-known risk factor for major postoperative morbidity. Interestingly, the reliability of surgeons to predict the ES prior to CRS + HIPEC is unknown.

Methods
In this prospective, observational cohort study, five surgeons predicted the ES prior to surgery in all consecutive patients with peritoneal metastases (PM) who were scheduled for CRS + HIPEC between March 2018 and May 2019. After the preoperative work-up for CRS + HIPEC was completed, all surgeons independently predicted, for each individual patient, the resection or preservation of 22 different anatomical structures and the presence of a stoma post-HIPEC according to a standardized ES form. The actual ES during CRS + HIPEC was extracted from the surgical procedure report and compared with the predicted ES. Overall and individual positive (PPV) and negative predictive values (NPV) for each anatomical structure were calculated.

Results
One hundred and thirty-one ES forms were collected from 32 patients who successfully underwent CRS + HIPEC. The number of resections was predicted correctly 24 times (18.3%), overestimated 57 times (43.5%), and underestimated 50 times (38.2%). Overall PPVs for the different anatomical structures ranged between 33.3 and 87.8%. Overall, NPVs ranged between 54.9 and 100%, and an NPV > 90% was observed for 12 anatomical structures.

Conclusions
Experienced surgeons seem to be able to better predict the anatomical structures that remain in situ after CRS + HIPEC, rather than predict the resections that were necessary to achieve a complete cytoreduction.
Clinical versus Functional Reaction Time: Implications for Postconcussion Management
Authors: LEMPKE LANDON B. , JOHNSON RACHEL S. , SCHMIDT JULIANNE D. , LYNALL ROBERT C. 
Published: February 2020

ABSTRACTPurposeThis study aimed to examine the association between clinical and functional reaction time (RT) assessments with and without simultaneous cognitive tasks among healthy individuals.MethodsParticipants (n= 41, 49% female; 22.5 ± 2.1 yr; 172.5 ± 11.9 cm; 71.0 ± 13.7 kg) completed clinical (drop stick, Stroop) and functional (gait, jump landing, single-leg hop, anticipated cut, unanticipated cut) RT assessments in random order. All RT assessments, except Stroop and unanticipated cut, were completed under single- (movement only) and dual-task conditions (movement and subtracting by 6s or 7s). Drop stick involved catching a randomly dropped rod embedded in a weighted disk. Stroop assessed RT via computerized neurocognitive testing. An instrumented walkway measured gait RT when center-of-pressure moved after random stimulus. All other functional RT assessments involved participants jumping forward and performing a vertical jump (jump landing), balancing on one leg (single-leg hop), or a 45° cut in a known (anticipated cut) or unknown (unanticipated cut) direction. RT was determined when the sacrum moved following random visual stimulus. Pearson correlation coefficients and a 5 × 2 repeated-measures ANOVA compared RT assessments and cognitive conditions.ResultsStroop RT outcomes did not significantly correlate with functional RT assessments (rrange = −0.10 to 0.24). A significant assessment by cognitive task interaction (F4,160= 14.01;P< 0.001) revealed faster single-task RT among all assessments compared with dual-task (mean differences, −0.11 to −0.09 s;P< 0.001), except drop stick (P= 0.195). Single-leg hop (0.58 ± 0.11 s) was significantly slower compared with jump landing (0.53 ± 0.10 s), anticipated cut (0.49 ± 0.09 s), gait (0.29 ± 0.07 s), and drop stick (0.21 ± 0.03 s;Pvalues ≤ 0.001). Dual-task assessments were significantly slower than single-task assessments (mean difference, 0.08 s;P< 0.001).ConclusionsClinical and functional RT assessments were not correlated with each other, suggesting that sport-like RT is not being assessed after concussion. Functional and dual-task RT assessments may add clinical value and warrant further exploration after concussion.
PERAN KEPALA SEKOLAH DALAM MENGEMBANGKAN KULTUR SEKOLAH DI SD MUHAMMADIYAH SANGONAN 2
Authors: Ilmasari Fahmadinna , Alhadi Said 
Published: February 2020

ABSTRACT This study aims to answer: 1) the role of school principals in developing school culture in Muhammadiyah Sangonan Elementary School 2, 2) supporting factors and obstacles for school principals in developing school culture in SD Muhammadiyah Sangonan 2.This type of research uses descriptive qualitative research. The subjects of this study were principals, teachers and students. Data collection techniques using triangulation techniques and sources. Data analysis techniques using interactive data models Miles and Huberman.The results of the study are as follows: 1) the role of the principal in developing school culture through 4 roles namely the role of the principal as manager, the role of the principal as leader, the role of the principal as an innovator and the role of the principal as motivator. The role of the principal as a manager includes the principal taking actions or efforts taken to develop school coursework (compiling the program), joint efforts of the teacher in developing a better school culture, mobilizing teachers to take part in implementing the developed school culture. Keywords: School Culture and the Role of Principals.
HUBUNGAN PENDEKATAN LINGKUNGAN ALAM SEKITAR (PLAS) DENGAN HASIL BELAJAR SISWA KELAS V SEKOLAH DASAR
Authors: Suprapto Hidayah Mulyaningsih 
Published: February 2020

This study aims to determine the relationship between the approach of the natural environment with the learning outcomes of students in grade V SD N 3 Klaten Grabag Magelang. The learning that is happening now has increased material that is taught increasingly difficult how to teach teachers is still conventional lack of media and facilities learning especially in natural science learning that requires concrete understanding. For this reason teachers need to innovate in learning one of them using the natural environment approach that can be used in science subjects. The subjects of this study were students of grade V SD N 3 Klaten as many as 32 children 16 children of the experimental group and 16 control groups selected by the object random sampling system in this study were natural science learning outcomes using a natural environment approach around data collection techniques used in the form of observation and documentation. this type of research is a quasi-experimental with pretest posttest control group design research method used is quantitative data analysis techniques in this study using t test with a significance level of 5%. The results of the study showed that the experimental group obtained the calculated thitung (7,580) > t tabel(df:15) (2,145), and the p (0,000) < dari 0,05 value with the results of the study meant that there was an increase in student learning outcomes in grade V SD N 3 Klaten using a significant natural environment approach to student learning outcomes so that it could be concluded that there was a significant relationship between the approaches the surrounding natural environment with student learning outcomes in the material Adjustment of living things with the environment in grade V SD Negeri 3 Klaten Grabag Magelang.
Wahrnehmung von Technik und Digitalisierung in Deutschland und Europa: Befunde aus dem TechnikRadar
Authors: Störk-Biber Constanze , Hampel Jürgen , Kropp Cordula , Zwick Michael 
Published: February 2020

ZusammenfassungDer vorliegende Beitrag stellt die Wahrnehmung von Technik und Digitalisierung in Deutschland und im Vergleich mit dem europäischen Ausland dar. Er geht auf die Ergebnisse des TechnikRadar aus den Jahren 2018 und 2019 zurück. Das TechnikRadar von acatech – Deutsche Akademie der Technikwissenschaften und Körber-Stiftung beleuchtet jährlich mit verschiedenem Fokus, was die Deutschen über Technik denken. Erstellt und wissenschaftlich ausgewertet wird es von den AutorInnen des Beitrags. 2018 und 2019 standen die Wahrnehmung und Bewertung der Digitalisierung im Mittelpunkt, wobei 2018 die Ergebnisse der Repräsentativbefragung in Deutschland vorgestellt und 2019 diese Ergebnisse sowohl einer vertiefenden Analyse zu alters- und geschlechtsspezifischen Unterschieden unterzogen als auch mit Befunden aus anderen internationalen Studien verglichen wurden. Anhand von Anwendungsfeldern wie dem autonomen Fahren, Pflegerobotik, Smart Home und der Digitalisierung von Infrastrukturen wird herausgestellt, wie Technik in den jeweiligen Kontexten wahrgenommen und welche Chancen und Risiken gesehen werden. Dabei zeigt sich, dass die eigene Kompetenzwahrnehmung in Bezug auf den Umgang mit digitalen Technologien und Diensten sowie das Vertrauen der Menschen in die Akteure der Digitalisierung wesentlich für eine grundlegende gesellschaftliche Akzeptanz von Digitalisierungsprozessen ist.
Treatment of Chronic Abdominal Pain With 10-kHz Spinal Cord Stimulation: Safety and Efficacy Results From a 12-Month Prospective, Multicenter, Feasibility Study
Authors: Kapural Leonardo , Gupta Mayank , Paicius Richard , Strodtbeck Wyndam , Vorenkamp Kevin E. , Gilmore Christopher , Gliner Bradford , Rotte Anand , Subbaroyan Jeyakumar , Province-Azalde Rose 
Published: February 2020

INTRODUCTION:
Chronic abdominal pain (CAP) can arise from multiple conditions, including inflammatory disorders, trauma because of injury or surgery, or structural or functional causes. This prospective, single-arm study was designed to evaluate the safety and efficacy of 10-kHz spinal cord stimulation (SCS) in patients with intractable CAP over a 12-month follow-up period.

METHODS:
Subjects with CAP who had been refractory to conventional medical treatment for at least 3 months resulting in self-reported pain scores of ≥5 cm on a 10-cm visual analog scale were enrolled at 4 centers in the United States. Study subjects underwent a trial stimulation lasting up to 14 days with epidural leads implanted from the vertebral levels T4 through T8. Subjects who had ≥40% pain relief during the trial stimulation period were implanted with a Senza system (Nevro Corp., Redwood City, CA) and followed up to 12 months after surgery.

RESULTS:
Twenty-three of 24 subjects (95.8%) had a successful trial stimulation and proceeded to a permanent implant. After 12 months of treatment with 10-kHz SCS, 78.3% of subjects were responders (pain relief of ≥50%) and 14 of 22 subjects (63.6%) were remitters (sustained ≤3.0-cm visual analog scale scores). Secondary outcomes, including assessments of disability, mental and physical well-being, sleep quality, perception of improvement, and satisfaction, showed that 10-kHz SCS greatly improved the quality of life of patients with CAP. Observationally, most subjects also reported concurrent reduction or resolution of nausea and/or vomiting.

DISCUSSION:
10-kHz SCS can provide durable pain relief and improve the quality of life in patients with CAP.