bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevant parameters for recommendations of physical activity in patients suffering from multiple myeloma
Authors: Cenik Fadime , Keilani Mohammad , Hasenöhrl Timothy , Huber Dominikus , Stuhlpfarrer Bianca , Pataraia Anna , Crevenna Richard 
Published: November 2019

Summary
Purpose
This pilot study aimed to describe physical performance, self-reported physical activity, health-related quality of life, anxiety and depression in patients who were assigned from Austrian self-help groups for multiple myeloma patients. These parameters were then discussed in the context of clinical decision-making concerning the recommended type of regular physical activity and exercise.

Methods
Members of the self-help groups were invited to participate. Physical performance and physical activity were assessed with the 6 min walk test (6MWT), handgrip strength test, timed up and go test (TUG), Tinetti performance oriented mobility assessment (POMA), falls efficacy scale (FES), international physical activity questionnaire (IPAQ), health-related quality of life (EORTC QLQ-C30) and the hospital anxiety and depression scale (HADS).

Results
A total of 40 patients (female:male = 15:25, mean age: 63.8 ± 9.0 years, range 41–80 years) were identified. In total 20 (50%) reached the performance of healthy peers in the tests 6MWT, handgrip strength, TUG and POMA, while 50% showed at least 1 result below the reference value or cut-off-point for each test. Self-reported activity levels were high. Patients showed a tendency to overestimate the risk of falling but a case by case analysis revealed a tendency for underestimating the actual performance in the respective tests (TUG, POMA).

Conclusion
The performance of healthy peers was reached by a substantial number of the participants in tests of physical performance and they reported high levels of physical activity. Nevertheless, they tended to overestimate the specific risk of falling. Patients with notably impaired physical performance might be suitable to perform regular physical activity and exercise in an individual therapy, whereas those with good physical performance are suited for training in exercise groups; however, individual contraindications and clinical considerations should be noted in a multiprofessional and interdisciplinary setting.
Private Hospital Workflow Optimization via Secure k-Means Clustering
Authors: Spini Gabriele , van Heesch Maran , Veugen Thijs , Chatterjea Supriyo 
Published: November 2019

AbstractOptimizing the workflow of a complex organization such as a hospital is a difficult task. An accurate option is to use a real-time locating system to track locations of both patients and staff. However, privacy regulations forbid hospital management to assess location data of their staff members. In this exploratory work, we propose a secure solution to analyze the joined location data of patients and staff, by means of an innovative cryptographic technique called Secure Multi-Party Computation, in which an additional entity that the staff members can trust, such as a labour union, takes care of the staff data. The hospital, owning location data of patients, and the labour union perform a two-party protocol, in which they securely cluster the staff members by means of the frequency of their patient facing times. We describe the secure solution in detail, and evaluate the performance of our proof-of-concept. This work thus demonstrates the feasibility of secure multi-party clustering in this setting.
The effect of drought and intercropping on chicory nutrient uptake from below 2 m studied in a multiple tracer setup
Authors: Rasmussen Camilla Ruø , Thorup-Kristensen Kristian , Dresbøll Dorte Bodin 
Published: November 2019

Abstract
Aims
We tested if chicory acquires nutrients from soil layers down to 3.5 m depth and whether the deep nutrient uptake increases as a result of drought or intercropping with ryegrass and black medic. We also tested whether application of the trace elements Cs, Li, Rb, Sr and Se, as tracers, result in similar uptake rates.

Methods
The methodological tests were carried out in a pilot experiment where the tracers were applied to 1 m depth in lucerne and red beet grown in tube rhizotrons. The dynamics of deep nutrient uptake in chicory was studied in large 4 m deep rhizoboxes. A drought was induced when roots had reached around 2 m depth.

Results
Chicory acquired 15N from 3.5 m depth and trace element tracers from 2.3 m depth. We found no compensatory tracer uptake with depth during drought. We found some indications of a compensatory tracer uptake from 2.3 and 2.9 m depth in intercropped chicory. Application of equimolar amounts of trace elements resulted in similar excess tracer concentrations within species.

Conclusion
Chicory demonstrates nutrient uptake from below 3 m but does not increase deep nutrient uptake as a response to limited topsoil nutrient availability induced by drought or intercropping.
Cyclodextrin conjugated ferritin nanocages reduce intracellular cholesterol level in foam cells
Authors: Ravishankar Samyukta , Lim Sierin 
Published: November 2019

AbstractAccumulation of lipid-laden macrophages (foam cells) is characteristic of atherosclerosis development in the arterial walls. Ferritin nanocages have been found to passively accumulate in the atherosclerotic plaque. Ferritin has been actively investigated as a carrier for contrast agents in atherosclerosis diagnosis. We demonstrate the potential of ferritin as a carrier for therapeutic molecules to mediate cholesterol reduction from foam cells. Cyclodextrin molecules are chemically conjugated to the ferritin nanocages surface or encapsulated within the nanocages using metal co-loading methods. The cyclodextrin-conjugated ferritin has nanomolar affinity to cholesterol molecules. Treatment of foam cells with the conjugates shows decreased levels of intracellular accumulated cholesterol. The preferential localization of ferritin to foam cells is due to transferrin receptor-mediated endocytosis process. These findings show that ferritin nanocages as carriers localize cyclodextrin molecules to foam cells which mediate intracellular cholesterol reduction, thus highlighting its potential use as a therapeutic agent.
Soil carbon enhancing practices: a systematic review of barriers and enablers of adoption
Authors: Ng’ang’a Stanley Karanja , Jalang’o Dorcas Anyango , Girvetz Evan Hartunian 
Published: November 2019

AbstractSustained adoption of soil carbon enhancing practices (SCEPs) at scale remains an aspiration goal to maintain sufficient amount of soil carbon in household farms in order to impact on the sustained farm productivity caused by sustained soil fertility. The objective of this study is to systematically evaluate the current evidence base to identify: (a) which factors enable or constrain adoption of SCEPs and hence maintain soil carbon in Kenya and Ethiopia; (b) to be able to lessons learnt concerning what influences the adoption of the SCEPs for the purpose of maintaining soil fertility among smallholder farms; and (c) how this can be improved going into the future for the purpose of formulating appropriate policies in Kenya and Ethiopia in both the short and long run. A systematic review was conducted using established review methodology and extensive searches of published and unpublished literature sources. Data extraction and quality appraisal of quantitative, qualitative and case studies that met the inclusion criteria were conducted while checking for reliability. A broad range of interrelated enabling and constraining factors was identified for the SCEPs. All the factors matter, and some of most of these factors are important to be considered during planning and implementation of SCEPs aiming at promoting soil carbon sequestration. Despite the limitation in the quantity of evidence, this systematic review provides a useful starting point for the scaling up programmes to ensure more effective adoption of SCEPs. This review also underscores the need for a multidisciplinary approach in understanding what determines the adoption of SCEPs to capture a holistic view.
Brief report: Patterns of prosocial behaviors in middle childhood predicting peer relations during early adolescence
Authors: Ma Ting‐Lan , Zarrett Nicole , Simpkins Sandra , Vandell Deborah L. , Jiang Su 
Published: November 2019

ABSTRACTIntroductionEarly adolescence is a developmental period in which peer victimization, bullying, relational aggression, and social exclusion are particularly prominent. As these behaviors have long‐term implications for children, in this study, we investigated early variations of prosocial behaviors as one of the critical precedents that shape youth's subsequent peer relational outcomes. Specifically, we identified different profiles of prosocial behaviors in middle childhood (Grade 4) and related these profiles to peer relationships in early adolescence (Grade 6).MethodUsing longitudinal data from the NICHD Study of Early Child Care and Youth Development (N = 914; 52% girls), a three‐step latent profile analysis was conducted on Grade 4 prosocial behaviors, which were then related to Grade 6 teacher‐ and student‐rated peer relationships (e.g., relational aggression).ResultsFour patterns of prosocial behaviors emerged: low prosocial (18%), high prosocial (67%), primarily friendly (8%), and primarily kind (7%). These four patterns of prosocial behaviors were differentially related to later problematic peer relationships: Low prosocial youth demonstrated the most problematic peer relationships (Mdiff = 0.36‐0.93, all p < .001). Primarily friendly (but not kind) youth displayed more general and relational aggression (Mdiff = 0.22, SE = 0.07, p = .002; and Mdiff = 0.18, SE = 0.06, p = .006, respectively).ConclusionBoth low prosocial and primarily friendly youth are at risk for displaying peer‐related problems; interventions that build prosocial behaviors in youth with a low prosocial or primarily friendly profile may help prevent problematic peer relationships at early adolescence.
Self-audits as alternatives to travel-audits for improving data quality in the Caribbean, Central and South America network for HIV epidemiology
Authors: Lotspeich Sarah C. , Giganti Mark J. , Maia Marcelle , Vieira Renalice , Machado Daisy Maria , Succi Regina Célia , Ribeiro Sayonara , Pereira Mario Sergio , Rodriguez Maria Fernanda , Julmiste Gaetane , Luque Marco Tulio , Caro-Vega Yanink , Mejia Fernando , Shepherd Bryan E. , McGowan Catherine C. , Duda Stephany N. 
Published: November 2019

AbstractIntroduction:Audits play a critical role in maintaining the integrity of observational cohort data. While previous work has validated the audit process, sending trained auditors to sites (“travel-audits”) can be costly. We investigate the efficacy of training sites to conduct “self-audits.”Methods:In 2017, eight research groups in the Caribbean, Central, and South America network for HIV Epidemiology each audited a subset of their patient records randomly selected by the data coordinating center at Vanderbilt. Designated investigators at each site compared abstracted research data to the original clinical source documents and captured audit findings electronically. Additionally, two Vanderbilt investigators performed on-site travel-audits at three randomly selected sites (one adult and two pediatric) in late summer 2017.Results:Self- and travel-auditors, respectively, reported that 93% and 92% of 8919 data entries, captured across 28 unique clinical variables on 65 patients, were entered correctly. Across all entries, 8409 (94%) received the same assessment from self- and travel-auditors (7988 correct and 421 incorrect). Of 421 entries mutually assessed as “incorrect,” 304 (82%) were corrected by both self- and travel-auditors and 250 of these (72%) received the same corrections. Reason for changing antiretroviral therapy (ART) regimen, ART end date, viral load value, CD4%, and HIV diagnosis date had the most mismatched corrections.Conclusions:With similar overall error rates, findings suggest that data audits conducted by trained local investigators could provide an alternative to on-site audits by external auditors to ensure continued data quality. However, discrepancies observed between corrections illustrate challenges in determining correct values even with audits.
Reappraisal of arctostylopid mammal Kazachostylops occidentalis from the late Paleocene of Kazakhstan and phylogenetic relationships within Arctostylopida
Authors: Averianov Alexander O. 
Published: November 2019

AbstractKazachostylops occidentalis Nesov, 1987b, based on partial maxilla and dentary from the upper Paleocene Zhylga locality in South Kazakhstan, is redescribed. A new phylogenetic hypothesis of Arctostylopida is proposed based on phylogenetic analysis of 26 characters and 17 taxa. Kazachostylops is recovered as a sister taxon to the Arctostylopinae, the advanced clade of Asian and North American arctostylopids characterized by pseudohypocone on upper molars and reduced trigonid of lower molars, with the ectolophid being attached labial on the trigonid. Kazachostylops differs from more basal arctostylopids (Asiostylops, Allostylops, Bothriostylops, and Wanostylops) by higher-crowned molars, M1–3 metaconule absent, m1–3 entoconid connected with ectolophid by entolophid, and m2 wider than m1 and m3. Principal component analyses of the upper and lower dentition of arctostylopids show great distinctness of Kazachostylops from other members of the group. The arctostylopid taxa are reviewed, and the new genus Enantiostylops is erected for ‘Sinostylops’ progressus Tang and Yan, 1976 from the lower Eocene of China, because of uniquely concave parastylar area on upper molars.UUID: http://zoobank.org/a46d8f29-fd73-4e59-88dc-fcc55b12d1d3
Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis
Authors: Chen Xiaoling , Luo Xiaoming , Chen Daiwen , Yu Bing , He Jun , Huang Zhiqing 
Published: November 2019

AbstractThe present study aimed to investigate whether arginine (Arg) promotes porcine type I muscle fibres formation via improving mitochondrial biogenesis. In the in vivo study, a total of sixty Duroc × Landrace × Yorkshire weaning piglets with an average body weight of 6·55 (sd 0·36) kg were randomly divided into four treatments and fed with a basal diet or a basal diet supplemented with 0·5, 1·0 and 1·5 % l-Arg, respectively, in a 4-week trial. Results showed that dietary supplementation of 1·0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group. In addition, ATPase staining analysis indicated that 1·0 % Arg supplementation significantly increased the number of type I muscle fibres and significantly decreased the number of type II muscle fibres. Furthermore, 1·0 % Arg supplementation significantly up-regulated PPAR-γ coactivator-1α (PGC-1α), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1α, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content. In the in vitro study, mitochondrial complex I inhibitor rotenone (Rot) was used. We found that Rot annulled Arg-induced type I muscle fibres formation. Together, our results provide for the first time the evidence that Arg promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis.
MOVING BEYOND COLONIAL CONTROL? ECONOMIC FORCES AND SHIFTING MIGRATION FROM RUANDA-URUNDI TO BUGANDA, 1920–60
Authors: DE HAAS MICHIEL 
Published: November 2019

AbstractMigration was a crucial component of the spatially uneven formation of labour markets and export-oriented economies in colonial Africa. Much of this mobility was initiated by migrants themselves rather than by colonial authorities. Building on analytical concepts from economic history and migration theory, this study explains the changing composition and magnitude of one such uncontrolled migration flow, from Ruanda-Urundi to Buganda. Migrants’ mobility choices – when to migrate, for how long, and with whom – proved highly responsive to shifting economic opportunity structures on the sending and receiving ends. Initially, large differences in terms of land and labour endowments, socio-economic structures, and colonial interventions, combined with substantial scope for price arbitrage, created large spatial inequalities of opportunity and strong incentives for circular male labour migration. Over time, however, migration contracted as opportunities in Ruanda-Urundi and Uganda converged, not in the least as a result of large-scale mobility itself.
A new species ofAtriophallophorusDeblock & Rosé, 1964 (Trematoda: Microphallidae) described fromin vitro-grown adults and metacercariae fromPotamopyrgus antipodarum(Gray, 1843) (Mollusca: Tateidae)
Authors: Blasco-Costa I. , Seppälä K. , Feijen F. , Zajac N. , Klappert K. , Jokela J. 
Published: November 2019

AbstractThe adult and metacercaria life stages of a new species of the microphallid genusAtriophallophorusDeblock & Rosé, 1964 are described from specimens collected at Lake Alexandrina (South Island, New Zealand). In addition to molecular analyses of ribosomal and mitochondrial genes, metacercariae ofAtriophallophorus winterbournin. sp. from the snail hostPotamopyrgus antipodarum(Gray) were grownin vitroto characterize internal and external morphology of adults using light and scanning electron microscopy and histological techniques.Atriophallophorus winterbournin. sp. is readily distinguishable fromAtriophallophorus coxiellaeSmith, 1973 by having a different structure of the prostatic chamber, sub-circular and dorsal to genital atrium, rather than cylindrical, fibrous, elongate and placed between the seminal vesicle and the genital atrium. The new species is most similar toAtriophallophorus minutus(Price, 1934) with regards to the prostatic chamber and the morphometric data, but possesses elongate-oval testes and subtriangular ovary rather than oval and transversely oval inA. minutus. Phylogenetic analyses including sequence data forA. winterbournin. sp. suggested a congeneric relationship of the new species to a hitherto undescribed metacercariae reported from Australia, both forming a strongly supported clade closely related toMicrophallusandLevinseniella. In addition, we provide an amended diagnosis ofAtriophallophorusto accommodate the new species and confirm the sinistral interruption of the outer rim of the ventral sucker caused by the protrusion of the dextral parietal atrial scale at the base of the phallus.
Rehabilitation as the Wage of Starvation: The 1941 Local 313 Sharecropper Strike's Critical Theory of Normativity
Authors: Kalina Kasia 
Published: November 2019

AbstractThis paper examines the 1941 pamphlet “Down with Starvation-Wages!,” written by Local 313 striking sharecroppers in Southeast Missouri, as it both anticipates and places into deep historical tension theories of normativity that would come to be associated with continental European critique after World War Two. The pamphlet's contents are both a local response to and critical theory of New Deal struggles over the meaning and bureaucratic administration of rehabilitation. I first examine the schematic history of federal Rehabilitation programs as they emerged in the biomedical context of the First World War and were then transformed in the agricultural-economic context of the New Deal era. Across these contexts, I demonstrate that their main discursive and procedural function was the cultivation of their white beneficiaries as economic and political self-sovereigns. I then argue that the brief attempt to extend this Agricultural Adjustment Administration-administered form of Rural Rehabilitation programming, ostensibly an index of citizenship, to 1939 striking sharecroppers constituted one attempt to dull the normative force of an organized population, which had long been treated as surplus. I outline the relocation of remaining protesters to the farming cooperative of Cropperville by the St. Louis Committee for the Rehabilitation of Sharecroppers as an intermediary mode of social management that aimed to prevent organized sharecropper protest without extending the promise of full citizenship. The Local's 1941 subsequent “starvation-wage” is thus a relational theory of racist exploitation that allowed the state of starvation to emerge among black persons. In its maintenance of various orders of black persons’ virtual value as perpetually unrealized, its economy is made to run through cycles of starvation, bondage, and debt; as well as nutrition, rehabilitation, and repair. The Local's subsequent endorsement of the 1941 strike and of coalitional organizing with white sharecroppers thus instrumentalizes the very uneven racist distribution of history and life chances by the starvation-wage as a political resource in elaborating potentially novel arrangements of life.
Dispatcher Identification of Out-of-Hospital Cardiac Arrest and Neurologically Intact Survival: A Retrospective Cohort Study
Authors: Mapp Julian G. , Darrington Anthony M. , Harper Stephen A. , Kharod Chetan U. , Miramontes David A. , Wampler David A. ,   Prehospital Research and Innovation in Military and Expeditionary Environments (PRIME) Research Group
Published: November 2019

AbstractIntroduction:To date, there are no published data on the association of patient-centered outcomes and accurate public-safety answering point (PSAP) dispatch in an American population. The goal of this study is to determine if PSAP dispatcher recognition of out-of-hospital cardiac arrest (OHCA) is associated with neurologically intact survival to hospital discharge.Methods:This retrospective cohort study is an analysis of prospectively collected Quality Assurance/Quality Improvement (QA/QI) data from the San Antonio Fire Department (SAFD; San Antonio, Texas USA) OHCA registry from January 2013 through December 2015. Exclusion criteria were: Emergency Medical Services (EMS)-witnessed arrest, traumatic arrest, age <18 years old, no dispatch type recorded, and missing outcome data. The primary exposure was dispatcher recognition of cardiac arrest. The primary outcome was neurologically intact survival (defined as Cerebral Performance Category [CPC] 1 or 2) to hospital discharge. The secondary outcomes were: bystander cardiopulmonary resuscitation (CPR), automated external defibrillator (AED) use, and prehospital return of spontaneous return of circulation (ROSC).Results:Of 3,469 consecutive OHCA cases, 2,569 cases were included in this analysis. The PSAP dispatched 1,964/2,569 (76.4%) of confirmed OHCA cases correctly. The PSAP dispatched 605/2,569 (23.6%) of confirmed OHCA cases as another chief complaint. Neurologically intact survival to hospital discharge occurred in 99/1,964 (5.0%) of the recognized cardiac arrest group and 28/605 (4.6%) of the unrecognized cardiac arrest group (OR = 1.09; 95% CI, 0.71–1.70). Bystander CPR occurred in 975/1,964 (49.6%) of the recognized cardiac arrest group versus 138/605 (22.8%) of the unrecognized cardiac arrest group (OR = 3.34; 95% CI, 2.70–4.11).Conclusion:This study found no association between PSAP dispatcher identification of OHCA and neurologically intact survival to hospital discharge. Dispatcher identification of OHCA remains an important, but not singularly decisive link in the OHCA chain of survival.