bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotherapists’ attitudes to intimate and informal behaviour towards clients
Authors: Vesentini Lara , Van Overmeire Roel , Matthys Frieda , De Wachter Dirk , Van Puyenbroeck Hubert , Bilsen Johan 
Published: March 2020

AbstractBackgroundTo avoid harming or exploiting a client, sexual and non-sexual dual relationship is generally considered as unacceptable in the psychotherapeutic relationship. However, little is known about what therapists themselves constitute as (un)acceptable intimate and informal behaviour (IIB).MethodsA survey among psychotherapists in Flanders (Belgium) was conducted. Opinions about the acceptability of IIB were asked. Based on these opinions attitude groups could be determined.ResultsIn total, 786 therapists completed and returned the questionnaire (response rate: 39.8%). Therapists could be divided into three attitude groups. Almost half of the therapists belonged to the ‘rather restrictive group’, a third to the ‘rather socially permissive group’ and a fifth to the ‘rather sexually permissive group’. Being categorised as ‘rather sexually permissive’ is predominantly related to being male and non-heterosexual, whereas being ‘rather restrictive’ or ‘rather socially permissive’ is mainly due to the type of psychotherapy training. The ‘rather sexually permissive’ therapists more often found a client sexually attractive during the last year and fantasised more often about a romantic relationship with a client, but they did not more often started a sexual relationship.ConclusionsMost therapists in Flanders are rather restrictive in their attitude to IIB, pointing to a high sense of morality. Having a rather sexually permissive attitude is predominantly related to more personal characteristics of the therapists, but these therapists did not start a sexual relationship more often.
ANALYTICALLY CLOSED-FORM SOLUTIONS FOR THE DISTRIBUTION OF A NUMBER OF CUSTOMERS SERVED DURING A BUSY PERIOD FOR SPECIAL CASES OF THEGEO/G/1QUEUE
Authors: Chaudhry M. L. , Goswami Veena , Mansur Abdalla 
Published: March 2020

AbstractThis paper presents the distribution of the number of customers served during a busy period for special cases of theGeo/G/1 queue when initiated withmcustomers. We analyze the system under the assumptions of a late arrival system with delayed access and early arrival system policies. It is not easy to invert the functional equation for the number of customers served during a busy period except for the simple caseGeo/Geo/1 queue, as stated by several researchers. Using the Lagrange inversion theorem, we give an elegant solution to this equation. We find the distribution of the number of customers served during a busy period for various service-time distributions such as geometric, deterministic, binomial, negative binomial, uniform, Delaporte, discrete phase-type and interrupted Bernoulli process. We compute the mean and variance of these distributions and also give numerical results. Due to the clarity of the expressions, the computations are very fast and robust. We also show that in the limiting case, the results tend to the analogous continuous-time counterparts.
SUMS OF SQUARES AND PARTITION CONGRUENCES
Authors: CUI SU-PING , GU NANCY S. S. 
Published: March 2020

AbstractFor positive integers $n$ and $k$, let $r_{k}(n)$ denote the number of representations of $n$ as a sum of $k$ squares, where representations with different orders and different signs are counted as distinct. For a given positive integer $m$, by means of some properties of binomial coefficients, we derive some infinite families of congruences for $r_{k}(n)$ modulo $2^{m}$. Furthermore, in view of these arithmetic properties of $r_{k}(n)$, we establish many infinite families of congruences for the overpartition function and the overpartition pair function.
Traditional law in times of the nation state: why is it so prevalent?
Authors: Gutmann Jerg , Voigt Stefan 
Published: March 2020

AbstractIn many modern nation states, both rich and poor, traditional law to this day plays an important role. Given the almost universal prevalence of traditional law, it is surprising how little we know about it. This is the first study that tries to take stock of traditional law from a cross-country perspective. We are also interested in the compatibility of traditional law with state-enforced law and, in particular, with the basic traits of the rule of law. Based on a sample of up to 134 countries, we find that no ‘typical’ traditional law exists, but that traditional law varies in many dimensions such as its timely enforcement, its impartiality, and its protection of basic human rights. Societies that rely extensively on traditional law score low regarding both the rule of law and per capita income. Historical and geographical factors are important predictors of the contemporaneous reliance on traditional law. State antiquity, for example, reduces the prevalence of traditional law, as does a high share of descendants from European populations.
Decreasing Magnetization, Lithospheric Flexure, and Rejuvenated Hydrothermalism off the Japan‐Kuril Subduction Zone
Authors: Choe Hanjin , Dyment Jerome 
Published: March 2020

AbstractSeafloor spreading magnetic anomalies formed at mid‐ocean ridges initially display strong amplitudes that decay within the first 10 million years as a result of pervasive hydrothermal circulation and alteration. The amplitudes do not vary much for older oceanic crust, suggesting that the thickening sediments hinder heat advection. Here we show, however, that a systematic loss of ~20% in the amplitude of the anomalies arises between the outer rise and the trench on old ocean crust approaching the Japan and Kuril subduction zones. We interpret this decay as reflecting the opening of normal faults and fissures caused by extension on the outer flexural rise and the subsequent renewed circulation of seawater into the oceanic crust, resulting in additional alteration of the magnetic minerals. This interpretation is supported by higher heat flow and seismic velocity changes observed toward the trench.
Urban Near‐Surface Seismic Monitoring Using Distributed Acoustic Sensing
Authors: Fang Gang , Li Yunyue Elita , Zhao Yumin , Martin Eileen R. 
Published: March 2020

AbstractUrban subsurface monitoring requires high temporal‐spatial resolution, low maintenance cost, and minimal intrusion to nearby life. Distributed acoustic sensing (DAS), in contrast to conventional station‐based sensing technology, has the potential to provide a passive seismic solution to urban monitoring requirements. Based on data recorded by the Stanford Fiber Optic Seismic Observatory, we demonstrate that near‐surface velocity changes induced by the excavation of a basement construction can be monitored using existing fiber optic infrastructure in a noisy urban environment. To achieve satisfactory results, careful signal processing comprising of noise removal and source signature normalization are applied to raw DAS recordings. Repeated blast signals from quarry sites provide free, unidirectional, and near‐impulsive sources for periodic urban seismic monitoring, which are essential for increasing the temporal resolution of passive seismic methods. Our study suggests that DAS will likely play an important role in urban subsurface monitoring.
Aerosol Indirect Effects on Cirrus Clouds Based on Global Aircraft Observations
Authors: Patnaude Ryan , Diao Minghui 
Published: March 2020

AbstractCirrus clouds have large climate impacts, yet aerosol indirect effects on cirrus microphysical properties remain highly uncertain. There is a lack of observational analysis on thermodynamic, dynamical, and aerosol indirect effects simultaneously, which limits the quantification of each effect. Using seven National Science Foundation aircraft campaigns, impacts of temperature, relative humidity, vertical velocity, and aerosols are individually quantified. Nonmonotonic correlations of ice water content, ice crystal number concentration (Ni), and mean diameter (Di) with respect to aerosol number concentrations (Na) are consistently seen at various conditions. Positive correlations become significant when Na > 500 nm (Na500) and >100 nm (Na100) are 3 and 10 times higher than average, respectively. While Na500 are more effective at temperatures closer to −40 °C with small vertical velocity fluctuations and are less sensitive to ice supersaturation, Na100 are more effective at colder temperatures with higher updraft and higher ice supersaturation, indicating heterogeneous and homogeneous nucleation mechanisms, respectively.
Water Security Assessment for the Contiguous United States Using Water Footprint Concepts
Authors: Veettil Anoop Valiya , Mishra Ashok 
Published: March 2020

AbstractWater security is tightly connected with the food security, ecological health, and economic prosperity of a region. In this study, a comprehensive water security assessment based on water footprint concepts from 1995 to 2015 was performed for the counties located in the Contiguous States of the Unites States. The availability of blue water (e.g., surface water) is comparatively less in the western river basins, and most of the rainfed agricultural lands in the eastern United States were characterized by the lower levels of green water (e.g., root zone soil moisture) storage. This integrated assessment of the water security indicators can directly map the critical regions and reveal the dependence between human water consumption, crop water requirements and environmental flow. This analysis can be further extended to incorporate climate change and extreme drought events to inform specific locations (e.g., counties and watersheds) at which problems of water conflict are more likely to occur.
Synthesis of Methane Observations Across Scales: Strategies for Deploying a Multitiered Observing Network
Authors: Cusworth Daniel H. , Duren Riley M. , Yadav Vineet , Thorpe Andrew K. , Verhulst Kristal , Sander Stanley , Hopkins Francesca , Rafiq Talha , Miller Charles E. 
Published: March 2020

AbstractRegional methane emissions monitoring is rapidly expanding with increased coverage of surface, airborne, and satellite instruments. We pilot a multitiered observing system in the Los Angeles Basin. We combine surface methane measurements from the Los Angeles Megacities Carbon Project, mountaintop retrievals from the CLARS‐FTS instrument, and space‐based XCH4 retrievals from the TROPOMI instrument into a single monitoring framework. We simulate these observations using a high‐resolution tracer transport model. Using inverse methods, we compare the sensitivity of each observing system component to various emissions sources. Combining multiple observing system into one framework allows for increased spatial and temporal sensitivity to methane emissions. We find a close correspondence between these inverse flux trends and independent airborne AVIRIS‐NG methane plume trends over a large landfill in the Los Angeles Basin. These results show that multitiered observing systems can reveal insights about sub‐basin scale methane emissions, which can be used to drive decision support.
Protein disulfide isomerase in cardiovascular disease
Authors: Xiong Bei , Jha Vishwanath , Min Jeong-Ki , Cho Jaehyung 
Published: March 2020

AbstractProtein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases. Increasing evidence indicates that intravascular cell-derived PDI plays an important role in the initiation and progression of cardiovascular diseases, including thrombosis and vascular inflammation. Recent studies with PDI conditional knockout mice have advanced our understanding of the function of cell-specific PDI in disease processes. Furthermore, the identification and development of novel small-molecule PDI inhibitors has led into a new era of PDI research that transitioned from the bench to bedside. In this review, we will discuss recent findings on the regulatory role of PDI in cardiovascular disease.
AQP1 modulates tendon stem/progenitor cells senescence during tendon aging
Authors: Chen Minhao , Li Yingjuan , Xiao Longfei , Dai Guangchun , Lu Panpan , Wang Youhua , Rui Yunfeng 
Published: March 2020

AbstractThe link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expression declines with age during tendon aging. In aged TSPCs, overexpression of AQP1 significantly attenuated TSPCs senescence. In addition, AQP1 overexpression also restored the age-related dysfunction of self-renewal, migration and tenogenic differentiation. Furthermore, we demonstrated that the JAK-STAT signaling pathway is activated in aged TSPCs, and AQP1 overexpression inhibited the JAK-STAT signaling pathway activation which indicated that AQP1 attenuates senescence and age-related dysfunction of TSPCs through the repression of JAK−STAT signaling pathway. Taken together, our findings demonstrated the critical role of AQP1 in the regulation of TSPCs senescence and provided a novel target for antagonizing tendon aging.
Stable species boundaries despite ten million years of hybridization in tropical eels
Authors: Barth Julia M. I. , Gubili Chrysoula , Matschiner Michael , Tørresen Ole K. , Watanabe Shun , Egger Bernd , Han Yu-San , Feunteun Eric , Sommaruga Ruben , Jehle Robert , Schabetsberger Robert 
Published: March 2020

AbstractGenomic evidence is increasingly underpinning that hybridization between taxa is commonplace, challenging our views on the mechanisms that maintain their boundaries. Here, we focus on seven catadromous eel species (genus Anguilla) and use genome-wide sequence data from more than 450 individuals sampled across the tropical Indo-Pacific, morphological information, and three newly assembled draft genomes to compare contemporary patterns of hybridization with signatures of past introgression across a time-calibrated phylogeny. We show that the seven species have remained distinct for up to 10 million years and find that the current frequencies of hybridization across species pairs contrast with genomic signatures of past introgression. Based on near-complete asymmetry in the directionality of hybridization and decreasing frequencies of later-generation hybrids, we suggest cytonuclear incompatibilities, hybrid breakdown, and purifying selection as mechanisms that can support species cohesion even when hybridization has been pervasive throughout the evolutionary history of clades.
Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
Authors: Tang Alison D. , Soulette Cameron M. , van Baren Marijke J. , Hart Kevyn , Hrabeta-Robinson Eva , Wu Catherine J. , Brooks Angela N. 
Published: March 2020

AbstractWhile splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences of these mutations. We report nanopore sequencing of full-length cDNA from CLL samples with and without SF3B1 mutation, as well as normal B cell samples, giving a total of 149 million pass reads. We present FLAIR (Full-Length Alternative Isoform analysis of RNA), a computational workflow to identify high-confidence transcripts, perform differential splicing event analysis, and differential isoform analysis. Using nanopore reads, we demonstrate differential 3’ splice site changes associated with SF3B1 mutation, agreeing with previous studies. We also observe a strong downregulation of intron retention events associated with SF3B1 mutation. Full-length transcript analysis links multiple alternative splicing events together and allows for better estimates of the abundance of productive versus unproductive isoforms. Our work demonstrates the potential utility of nanopore sequencing for cancer and splicing research.
Linking landscape-scale conservation to regional and continental outcomes for a migratory species
Authors: Mattsson B. J. , Devries J. H. , Dubovsky J. A. , Semmens D. , Thogmartin W. E. , Derbridge J. J. , Lopez-Hoffman L. 
Published: March 2020

AbstractLand-use intensification on arable land is expanding and posing a threat to biodiversity and ecosystem services worldwide. We develop methods to link funding for avian breeding habitat conservation and management at landscape scales to equilibrium abundance of a migratory species at the continental scale. We apply this novel approach to a harvested bird valued by birders and hunters in North America, the northern pintail duck (Anas acuta), a species well below its population goal. Based on empirical observations from 2007–2016, habitat conservation investments for waterfowl cost $313 M and affected <2% of the pintail’s primary breeding area in the Prairie Pothole Region of Canada. Realistic scenarios for harvest and habitat conservation costing an estimated $588 M (2016 USD) led to predicted pintail population sizes <3 M when assuming average parameter values. Accounting for parameter uncertainty, converting 70–100% of these croplands to idle grassland (cost: $35.7B–50B) is required to achieve the continental population goal of 4 M individuals under the current harvest policy. Using our work as a starting point, we propose continued development of modeling approaches that link conservation funding, habitat delivery, and population response to better integrate conservation efforts and harvest management of economically important migratory species.
A twenty-year deposition record of elemental carbon in Northern Japan retrieved from archived filters
Authors: Kaneyasu Naoki , Matsumoto Kiyoshi , Yamaguchi Takashi , Noguchi Izumi , Murao Naoto , Yasunari Teppei J. , Ikemori Fumikazu 
Published: March 2020

AbstractThe black carbon or elemental carbon (EC) content in ice and snow has been a concern in climate change studies, but time-series records have mostly been obtained from glacier ice-core samples in limited geographical locations, such as the Arctic or high mountains. This is the first study to present decade-long records of EC deposition measured at urban (Sapporo) and background (Rishiri Island) sites in Japan, in the mid-latitude zone of the eastern edge of the Asian continent. By using archived membrane filters from an acid rain study, we retrieved monthly EC deposition records of 1993–2012 in Sapporo and intermittent deposition data in Rishiri. Annual EC deposition showed large fluctuations, with a maximum in 2000–2001 and a minor increase in 2010–2011. This interannual change was moderately related to the deposition of non-sea salt SO42−and the collected water volume but did not reflect the estimated emission history of China. High depositions in 2000–2001 were probably caused by the transport of Asian Dust accompanied by air pollutants, which were characteristically active in these years. The findings of this study have implications for the use of observational data in validating global aerosol transport models.
Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease
Authors: Tomaro-Duchesneau Catherine , LeValley Stephanie L. , Roeth Daniel , Sun Liang , Horrigan Frank T. , Kalkum Markus , Hyser Joseph M. , Britton Robert A. 
Published: March 2020

AbstractEarly work in rodents highlighted the gut microbiota’s importance in metabolic disease, including Type II Diabetes Mellitus (T2DM) and obesity. Glucagon-like peptide-1 (GLP-1), an incretin secreted by L-cells lining the gastrointestinal epithelium, has important functions: promoting insulin secretion, insulin sensitivity, and β-cell mass, while inhibiting gastric emptying and appetite. We set out to identify microbial strains with GLP-1 stimulatory activity as potential metabolic disease therapeutics. Over 1500 human-derived strains were isolated from healthy individuals and screened for GLP-1 modulation by incubating bacterial cell-free supernatants with NCI H716 L-cells. Approximately 45 strains capable of increasing GLP-1 were discovered. All GLP-1 positive strains were identified as Staphylococcus epidermidis by 16S rRNA sequencing. Mass spectrometry analysis identified a 3 kDa peptide, Hld (delta-toxin), present in GLP-1 positive supernatants but absent in GLP-1 neutral supernatants. Studies in NCI-H716 cells and human jejunal enteroids engineered to make more enteroendocrine cells demonstrated that Hld alone is sufficient to enhance GLP-1 secretion. When administered in high-fat-fed mice, Hld-producing S. epidermidis significantly reduced markers associated with obesity and T2DM. Further characterization of Hld suggests GLP-1 stimulatory action of Hld occurs via calcium signaling. The presented results identify a novel host-microbe interaction which may ultimately lead to the development of a microbial peptide-based therapeutic for metabolic disease.
CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system
Authors: Pomper Nathan , Liu Yating , Hoye Mariah L. , Dougherty Joseph D. , Miller Timothy M. 
Published: March 2020

AbstractmicroRNAs are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landscape of a cell. Similar to mRNA, they often exhibit cell type enriched expression and serve to reinforce cellular identity. In tissue with high cellular complexity, such as the central nervous system (CNS), it is difficult to attribute microRNA changes to a particular cell type. To facilitate interpretation of microRNA studies in these tissues, we used previously generated data to develop a publicly accessible and user-friendly database to enable exploration of cell type enriched microRNA expression. We provide illustrations of how this database can be utilized as a reference as well as for hypothesis generation. First, we suggest a putative role for miR-21 in the microglial spinal injury response. Second, we highlight data indicating that differential microRNA expression, specifically miR-326, may in part explain regional differences in inflammatory cells. Finally, we show that miR-383 expression is enriched in cortical glutamatergic neurons, suggesting a unique role in these cells. These examples illustrate the database’s utility in guiding research towards unstudied regulators in the CNS. This novel resource will aid future research into microRNA-based regulatory mechanisms responsible for cellular phenotypes within the CNS.