bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing and Heeding the Voices of those With Advanced Illnesses
Authors: Piderman Katherine M. , Radecki Breitkopf Carmen , Jenkins Sarah M. , Ingram Cory , Sytsma Terin T. , Lapid Maria I. , Tata Beba S. , Chatterjee Krishanu , Egginton Jason S. , Jatoi Aminah 
Published: May 2020

Objectives: To describe the feasibility of a chaplain-led spiritually focused life review interview and the development of a spiritual legacy document (SLD) for patients with advanced diseases and to describe changes in spiritual well-being (SWB), spiritual coping strategies (SC), and quality of life (QOL) after receiving the SLD. Patients and Methods: In all, 130 patients and support person (SP) pairs were recruited from July 2012 to January 2019. Following enrollment, demographic information was gathered and baseline questionnaires were administered. Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being Scale (FACIT-Sp-12) and a linear analog scale assessment (LASA) measured SWB. LASAs also measured QOL and emotional well-being (EWB). Positive Religious Coping Scale (RCOPE) measured SC. After completion of baseline forms, participants were interviewed (individually) by a chaplain. Interviews were digitally recorded, transcribed, and verified. Transcripts were edited and participants were given the opportunity to make adaptations. The participant-approved draft was then developed into a professionally printed SLD. Follow-up questionnaires were administered to assess change. Results: Significant improvements from baseline to post-SLD follow-up were found for patients on the LASAs: SWB (average 7.7-8.3, P = .01), QOL (average 6.7-7.3, P = .03), EWB (average 6.9-7.5, P = .01), and on the positive RCOPE (average 1.8-2.0, P = .007). Effect sizes were approximately 0.25. Considering any improvement, 61.0% improved their positive RCOPE score, 46.6% improved EWB, and 39.7% improved SWB. No significant changes were found on the FACIT-Sp-12. No significant changes were found for SPs. Conclusion: The results suggest that the primary participants who completed the study benefited by significantly increasing their QOL, SWB, EWB, and SC.
Long-Lasting Insecticidal Net Utilization and Associated Factors Among Pregnant Women in Asgede Tsimbla District, Northern Ethiopia, 2017
Authors: Angesom Teklit , Gebreyesus Hailay , Gebremariam Brhane 
Published: May 2020

Background: Malaria among pregnant women contributes to maternal anemia, low birth weight, spontaneous abortion, and infant deaths. In response to this serious health problem, regular use of the long-lasting insecticidal net is the most cost-effective method of preventing malaria. However, in most developing countries, including Ethiopia, long-lasting insecticidal net utilization by pregnant women is uncertain. Objectives: This study was conducted to measure the utilization of insecticidal net and to identify the associated factors with its utilization among pregnant women in Asgede Tsimbla district in 2017. Methods: A community-based cross-sectional study was employed and data were collected using interviewer-administered questionnaire. Systematic random sampling method was used to select 550 pregnant women. Data were entered into a computer using Epi Info (version 7) and exported to Statistical Package for the Social Sciences (version 21) for further analysis. Variables with P-value less than 0.05 were used to declare statistical significance between the dependent and the independent variables in multivariable logistic regression. Results: Among 550 pregnant women surveyed, 347 (63.1%) of the pregnant women slept under a long-lasting insecticidal net the night before the survey. Urban residence (OR [95% CI] = 1.9 [1.22-3.01]), family size of 3-5 and >5 (2.8 [1.53-5.22] and 2.4 [1.20-5.03], respectively), and history of malaria during their current pregnancy (3.0 [1.95-4.86]) were found to be the factors associated with pregnant women’s long-lasting insecticidal net utilization. Conclusion: Utilization of long-lasting insecticidal net was low, and place of residence, exposure status to malaria during their current pregnancy, and family size were the factors associated with long-lasting insecticidal net utilization.
Are insulin-resistance and oxidative stress cause or consequence of aging
Authors: Dzięgielewska-Gęsiak Sylwia , Stołtny Dorota , Brożek Alicja , Muc-Wierzgoń Małgorzata , Wysocka Ewa 
Published: May 2020

Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR < 0,3 ( n = 35, median age 69.0 years) and insulin-resistant group (InsR) IR ≥ 0.3 ( n = 51, median age 71.0 years). Lipids and antioxidant defense system markers did not differentiate the investigated groups. In the InsR elderly group, the FAT was increased ( P < 0.000003) and TBARS ( P = 0.008) concentration decreased in comparison with InsS group. A positive correlation for SOD-1 and total antioxidant status ( P < 0.05; r =  0.434) and a negative correlation for TBARS and age ( P < 0.05 with r = −0.421) were calculated in InsR individuals. In elderly individuals, oxidative stress persists irrespective of insulin-resistance status. We suggest that increased oxidative stress may be consequence of old age. An insulin action identifies those at high risk for atherosclerosis, via congruent associations with oxidative stress and extra- and intra-cellular antioxidant defense systems. Thus, we maintain that insulin-resistance is not the cause of aging. Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.
Development of a Group-Based Community Health Worker Intervention to Increase Colorectal Cancer Screening Among Latinos
Authors: De La Torre C. L. , Dumbauld J. N. , Haughton J. , Gupta S. , Nodora J. , Giacinto R. Espinoza , Ramers C. , Bharti B. , Wells K. , Lopez J. , Díaz M. , Moody J. , Arredondo Elva M. 
Published: May 2020

Introduction: Latinos are at higher risk of colorectal cancer (CRC) mortality than non-Hispanic Whites due, in part, to disparities in cancer screening. There is a need to evaluate community-based CRC interventions as they may reach underinsured communities and those at highest risk for CRC. This article describes the development of a group-based CRC intervention ( Juntos contra el Cancer). Method: Purposive sampling was used to recruit Latino men and women aged 50 to 75 years not-up-to-date with CRC screening. The development of the intervention was guided by the socioecologic framework, a community needs assessment, literature reviews, five focus groups ( n = 39) from the target community and feedback from a Community Advisory Board. Results: Findings from focus groups suggested that a group-based, promotor or community health worker (CHW) led, cancer prevention education with linkages to care would address barriers to CRC screening. Conclusion: Development of community-based CRC screening interventions should be informed by early and sustained community engagement. Interventions led by CHWs with linkages to care are feasible and can reach populations not connected to health care settings.
Is constraint implant with metaphyseal sleeve a viable option for revision TKR with preoperative coronal plane instability and bone defect?
Authors: Lai Mun Chun , Chen Jerry Yongqiang , Liow Ming Han Lincoln , Tay Darren Keng Jin , Lo Ngai Nung , Pang Hee Nee , Yeo Seng Jin 
Published: May 2020

Background: Metaphyseal sleeves have been used as metaphyseal filling implants to address bone loss during revision total knee replacements (TKRs). This study aims to compare the 2-year clinical and radiological outcomes of constraint implant with bone defect and constraint implant without or minimal bone defect in revisions TKR with preoperative coronal plane instability. Materials and Methods: Seventeen cases of constraint implants with metaphyseal sleeve matched paired with 34 cases of constrained condylar knee (CCK) prosthesis. Age, gender, body mass index and aetiology for revision surgery were recorded. Clinical outcome measures included Knee Society Knee Score (KSKS), Knee Society Function Score (KSFS), Oxford Knee Score (OKS), physical component summary (PCS) and mental component summary (MCS). Radiological outcome measures included joint line changes, hip–knee–ankle angle (HKA), coronal femoral angle (CFA) and coronal tibial angle (CTA). Result: Patients in sleeve group showed significant improvement in KSKS, KSFS and OKS (38 ± 7, 35 ± 6 and 20 ± 2 points, respectively, p < 0.001), while they were 19 ± 3 and 6 ± 2 points for PCS and MCS, respectively ( p < 0.001 and p = 0.021). These postoperative scores after surgery were similar between the two groups at 6 months and 2 years. The sleeve provides comparable result in joint line restoration; the postoperative HKA, CFA and CTA were all comparable between the two groups. Conclusion: Metaphyseal sleeve with constraint implant is a viable option for revision TKR with preoperative coronal plane instability and significant bone defect. It is able to achieve similar clinical outcomes and joint line restoration compared to CCK prosthesis at 2-year follow-up.
Degradation of shear performance of screwed joints caused by wood decay
Authors: Ueda Rintaro , Sawata Kei , Takanashi Ryuya , Sasaki Yoshihisa , Sasaki Takanobu 
Published: May 2020

AbstractShear tests were conducted on screwed joints with decayed main members, and the degradation of shear performance of screwed joints by wood decay was investigated. The differences between decayed and control specimens in yield load (Py), and maximum load (Pmax) were both significant at the 1% level, while the difference in the initial stiffness (Ks) was not significant at the 5% level. The extent of decay was evaluated through Pilodyn penetration depth and the decay depth. Pilodyn penetration depth had no significant relationships with Ks, Py, or Pmax of screwed joints. It is inferred that no significant relationship was found between Pilodyn penetration depth and the strength properties because the range of the measured Pilodyn penetration depth was narrow (16–23.5 mm). The decay depth had a significant inverse correlation with Ks of the decayed specimens. There was no significant relationship between the decay depth and Py, or Pmax. Multiple regression analysis was conducted on Ks, Py, and Pmax using the decay depth and sound wood density (WDh) as 2 explanatory variables. The multiple regression of Ks, Py, and Pmax on the decay depth and WDh were significant at the 1%, 5%, and 1% level, respectively. Ks, Py, and Pmax are inferred to be determined by both the decay depth and WDh. The strength properties of screwed joints with one screw obtained in this study were compared with those of screwed joints with seven screws obtained in a previous study. The difference between Ks, Py, and Pmax of the screwed joints with one screw and those of the screwed joints with seven screws was not significant at the 5% level. It is inferred that shear performance of screw joints with multiple screws are sufficiently estimated from those of screw joints with one screw by simply multiplying the strength properties, even if the main members were decayed.
The impact of remission and coexisting migraine on anxiety and depression in cluster headache
Authors: Kim Byung-Su , Chung Pil-Wook , Kim Byung-Kun , Lee Mi Ji , Park Jeong Wook , Chu Min Kyung , Ahn Jin-Young , Bae Dae Woong , Song Tae-Jin , Sohn Jong-Hee , Oh Kyungmi , Kim Daeyoung , Kim Jae-Moon , Kim Soo-Kyoung , Choi Yun-Ju , Chung Jae Myun , Moon Heui-Soo , Chung Chin-Sang , Park Kwang-Yeol , Cho Soo-Jin 
Published: May 2020

Abstract
Background
Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

Methods
We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods.

Results
Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35–15.99 and aOR = 4.95, 95% CI = 2.32–10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63–159.64 and aOR = 16.88, 95% CI = 4.16–68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 ± 5.6 to 1.6 ± 2.8; P < 0.001, and from 6.1 ± 5.0 to 1.8 ± 2.4; P < 0.001, respectively).

Conclusions
Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.
New risk score for predicting steroid resistance in patients with focal segmental glomerulosclerosis or minimal change disease
Authors: Weng Qinjie , Zhou Qiongxiu , Tong Jun , Jin Yuanmeng , Liu Yunzi , Yu Xialian , Pan Xiaoxia , Ren Hong , Wang Weiming , Xie Jingyuan , Chen Nan 
Published: May 2020

Abstract
Background
Glucocorticosteroid is used for patients with primary nephrotic syndrome. This study aims to identify and validate that biomarkers can be used to predict steroid resistance.

Methods
Our study contained two stages, discovery and validation stage. In discovery stage, we enrolled 51 minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) patients treated with full dose steroid. Five urinary biomarkers including β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) were tested and candidates’ biomarkers were selected based on their associations with steroid response. In validation stage, candidates’ biomarkers were validated in two prospectively enrolled cohorts. Validation cohort A included 157 FSGS/MCD patients. Validation cohort B included 59 membranous nephropathy (MN) patients. Patients were classified into response group (RG) or non-response group (NRG) based on their responses to steroid treatment.

Results
In discovery stage, higher urinary β2-MG was independently associated with response to corticosteroid treatment in MCD/FSGS patients [OR = 1.89, 95% CI 1.02–3.53] after adjusted by age and gender. In validation cohort A, patients in NRG had a significant higher urinary β2-MG [Ln (β2-MG/uCr): 4.6 ± 1.7 vs 3.2 ± 1.5] compared to patients in RG. We then developed a 3-variable risk score in predicting steroid resistance in FSGS/MCD patients based on the best predictive model including Ln(β2-MG/uCr) [OR = 1.76, 95% CI 1.30–2.37], age [OR = 1.005, 95% CI 0.98–1.03] and pathology [MCD vs FSGS, OR = 0.20, 95% CI 0.09–0.46]. The area under the ROC curves of the risk score in predicting steroid response was 0.80 (95% CI 0.65–0.85). However, no such association was found in MN patients.

Conclusions
Our study identified a 3-variable risk score in predicting steroid resistance in patients with FSGS or MCD.
Seasonal variability of stable isotopes in the Changjiang (Yangtze) river water and its implications for natural climate and anthropogenic impacts
Authors: Li Chao , Lian Ergang , Yang Chengfan , Deng Kai , Qian Peng , Xiao Shangbin , Liu Zhongfang , Yang Shouye 
Published: May 2020

Abstract
Background
Seasonal variations of stable hydrogen and oxygen isotopes in river water can be used to indicate hydrological processes and the water cycle in the river basin. This study presents a high-resolution time series of stable oxygen isotopic record (δ18O) in the lower Changjiang (Yangtze) River mainstream and aims to investigate the regional water cycle concerning natural climate changes and anthropogenic activities.

Results
The river water δ18O shows apparent seasonal variations, which is overall higher during the dry season and lower during the flood season. This basin-scale seasonal variation of δ18O in precipitation over the Changjiang catchment is calculated based on the long-term meteorological and hydrological data. The seasonal variation of δ18O in the lower Changjiang river water is largely constrained by monsoon-induced precipitation, but is more directly controlled by the mixing of waters from the upper reaches and the tributary lakes in the middle valley.

Conclusions
The relative contributions of waters from the upstream and tributary lakes to the lower Changjiang mainstream have been considerably altered by the construction of Three Gorges Dam via the regulation of river discharges. A comparison of river water isotopic records with water discharges from the lakes suggests that it takes about 2 weeks (~ 17 days) for the Changjiang river water to circumvent the mid-lower reaches of the catchment before traveling to the sea. This study suggests that the stable hydrogen and oxygen isotopes can be harnessed as sensitive indicators for water cycling within a large catchment that is driven primarily by natural forcing though subject to substantial human impacts.
The corrected gene proximity map for analyzing the 3D genome organization using Hi-C data
Authors: Ye Cheng , Paccanaro Alberto , Gerstein Mark , Yan Koon-Kiu 
Published: May 2020

Abstract
Background
Genome-wide ligation-based assays such as Hi-C provide us with an unprecedented opportunity to investigate the spatial organization of the genome. Results of a typical Hi-C experiment are often summarized in a chromosomal contact map, a matrix whose elements reflect the co-location frequencies of genomic loci. To elucidate the complex structural and functional interactions between those genomic loci, networks offer a natural and powerful framework.

Results
We propose a novel graph-theoretical framework, the Corrected Gene Proximity (CGP) map to study the effect of the 3D spatial organization of genes in transcriptional regulation. The starting point of the CGP map is a weighted network, the gene proximity map, whose weights are based on the contact frequencies between genes extracted from genome-wide Hi-C data. We derive a null model for the network based on the signal contributed by the 1D genomic distance and use it to “correct” the gene proximity for cell type 3D specific arrangements. The CGP map, therefore, provides a network framework for the 3D structure of the genome on a global scale. On human cell lines, we show that the CGP map can detect and quantify gene co-regulation and co-localization more effectively than the map obtained by raw contact frequencies. Analyzing the expression pattern of metabolic pathways of two hematopoietic cell lines, we find that the relative positioning of the genes, as captured and quantified by the CGP, is highly correlated with their expression change. We further show that the CGP map can be used to form an inter-chromosomal proximity map that allows large-scale abnormalities, such as chromosomal translocations, to be identified.

Conclusions
The Corrected Gene Proximity map is a map of the 3D structure of the genome on a global scale. It allows the simultaneous analysis of intra- and inter- chromosomal interactions and of gene co-regulation and co-localization more effectively than the map obtained by raw contact frequencies, thus revealing hidden associations between global spatial positioning and gene expression. The flexible graph-based formalism of the CGP map can be easily generalized to study any existing Hi-C datasets.
Testing the advantages and disadvantages of short- and long- read eukaryotic metagenomics using simulated reads
Authors: Pearman William S. , Freed Nikki E. , Silander Olin K. 
Published: May 2020

Abstract
Background
The first step in understanding ecological community diversity and dynamics is quantifying community membership. An increasingly common method for doing so is through metagenomics. Because of the rapidly increasing popularity of this approach, a large number of computational tools and pipelines are available for analysing metagenomic data. However, the majority of these tools have been designed and benchmarked using highly accurate short read data (i.e. Illumina), with few studies benchmarking classification accuracy for long error-prone reads (PacBio or Oxford Nanopore). In addition, few tools have been benchmarked for non-microbial communities.

Results
Here we compare simulated long reads from Oxford Nanopore and Pacific Biosciences (PacBio) with high accuracy Illumina read sets to systematically investigate the effects of sequence length and taxon type on classification accuracy for metagenomic data from both microbial and non-microbial communities. We show that very generally, classification accuracy is far lower for non-microbial communities, even at low taxonomic resolution (e.g. family rather than genus). We then show that for two popular taxonomic classifiers, long reads can significantly increase classification accuracy, and this is most pronounced for non-microbial communities.

Conclusions
This work provides insight on the expected accuracy for metagenomic analyses for different taxonomic groups, and establishes the point at which read length becomes more important than error rate for assigning the correct taxon.