bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labour Law Arbitration
Authors: Timm Luciano Benetti , Verçosa Fabiane 
Published: November 2020

Abstract
This chapter highlights labour law arbitration in Brazil. Traditionally, labour law in Brazil recognises two main groups of rights: individual and collective rights. Individual labour relations are concerned with the relationship between individual workers and their employers. Collective labour relations refer to the social relationships generated through processes of consultation and negotiation—over working conditions, labour standards, and other employment issues—between, on the one hand, the workers' collective or their representatives and, on the other hand, the employers or employers’ organization. Even before the Labour Legislation Reform of 2017, Brazilian legal order already provided in its Constitution and in other legal statutes the possibility of arbitration for collective labour rights. On the other hand, before the promulgation of the Labour Legislation Reform, there was no provision under Brazilian Law that would open the possibility of arbitration in the event of individual labour disputes.
Genomic Architecture of Rapid Parallel Adaptation to Fresh Water in a Wild Fish
Authors: Zong Shao-Bing , Li Yu-Long , Liu Jin-Xian 
Published: November 2020

AbstractRapid adaptation to novel environments may drive changes in genomic regions through natural selection. However, the genetic architecture underlying these adaptive changes is still poorly understood. Using population genomic approaches, we investigated the genomic architecture that underlies rapid parallel adaptation of Coilia nasus to fresh water by comparing four freshwater-resident populations with their ancestral anadromous population. Linkage disequilibrium network analysis and population genetic analyses revealed two putative large chromosome inversions on LG6 and LG22, which were enriched for outlier loci and exhibited parallel association with freshwater adaptation. Drastic frequency shifts and elevated genetic differentiation were observed for the two chromosome inversions among populations, suggesting that both inversions would undergo divergent selection between anadromous and resident ecotypes. Enrichment analysis of genes within chromosome inversions showed significant enrichment of genes involved in metabolic process, immunoregulation, growth, maturation, osmoregulation, and so forth, which probably underlay differences in morphology, physiology and behavior between the anadromous and freshwater-resident forms. The availability of beneficial standing genetic variation, large optimum shift between marine and freshwater habitats, and high efficiency of selection with large population size could lead to the observed rapid parallel adaptive genomic change. We propose that chromosomal inversions might have played an important role during the evolution of rapid parallel ecological divergence in the face of environmental heterogeneity in C. nasus. Our study provides insights into the genomic basis of rapid adaptation of complex traits in novel habitats and highlights the importance of structural genomic variants in analyses of ecological adaptation.
Novel 2D CaCl crystals with metallicity, room-temperature ferromagnetism, heterojunction, piezoelectricity-like property and monovalent calcium ions
Authors: Zhang Lei , Shi Guosheng , Peng Bingquan , Gao Pengfei , Chen Liang , Zhong Ni , Mu Liuhua , Zhang Lijuan , Zhang Peng , Gou Lu , Zhao Yimin , Liang Shanshan , Jiang Jie , Zhang Zejun , Ren Hongtao , Lei Xiaoling , Yi Ruobing , Qiu Yinwei , Zhang Yufeng , Liu Xing , Wu Minghong , Yan Long , Duan Chungang , Zhang Shengli , Fang Haiping 
Published: November 2020

Abstract
Under ambient conditions, the only known valence state of calcium ions is +2, and the corresponding crystals with calcium ions are insulating and nonferromagnetic. Here, using cryo-electron microscopy, we report direct observation of two-dimensional (2D) CaCl crystals on reduced graphene oxide (rGO) membranes, in which the calcium ions are only monovalent (i.e. +1). Remarkably, metallic rather than insulating properties are displayed by those CaCl crystals. More interestingly, room-temperature ferromagnetism, graphene–CaCl heterojunction, coexistence of piezoelectricity-like property and metallicity, as well as the distinct hydrogen storage and release capability of the CaCl crystals in rGO membranes are experimentally demonstrated. We note that such CaCl crystals are obtained by simply incubating rGO membranes in salt solutions below the saturated concentration, under ambient conditions. Theoretical studies suggest that the formation of those abnormal crystals is attributed to the strong cation-π interactions of the Ca cations with the aromatic rings in the graphene surfaces. The findings highlight the realistic potential applications of such abnormal CaCl material with unusual electronic properties in designing novel transistors and magnetic devices, hydrogen storage, catalyzers, high-performance conducting electrodes and sensors, with a size down to atomic scale.
Fiscal sustainability under entitlement spending
Authors: Cerniglia Floriana , Dia Enzo , Hughes Hallett Andrew 
Published: November 2020

AbstractWe develop a simple theoretical framework that can be used not only to assess the stability of debt, but also to evaluate the sustainability of the commitments of the public sector in the presence of entitlement spending. We model the optimal intertemporal path of fiscal variables and the optimal policy responses in this environment, which requires a dynamic framework. Our analysis suggests that even with near-zero interest rates the stability of debt is not guaranteed and that the sustainability of public finances depends on the level of taxes and the persistence of expenditure, as much as on the level of debt. We estimate the model with panel data techniques, finding that our modelling strategy is supported by the empirical evidence and we use calibrated versions of our model to compare different countries.
Discovery of a new extreme changing-state quasar with 4 mag variation, SDSS J125809.31+351943.0
Authors: Nagoshi Shumpei , Iwamuro Fumihide , Wada Kazuma , Saito Tomoki 
Published: November 2020

Abstract
We report the discovery of a quasar, SDSS J125809.31+351943.0 (J1258), which brightened in optical wavelengths for 4 mag from 1983 to 2015: one of the largest quasar brightening events so far. The history of optical photometry data of this quasar from the Catalina Real-time Transient Survey and All Sky Automated Survey for Super Novae (ASAS-SN), mid-infrared photometry data from the WISE satellite, and the broad emission line (BEL) flux obtained by spectroscopy of the Sloan Digital Sky Survey shows significant increases between 2003 and 2015. Investigating the Canada–France–Hawaii Telescope photometric observations in 1983 and the United States Naval Observatory B catalogue, which contains data from 1975 and 1969, we found that the source was 4 mag fainter before than at the peak of the recent ASAS-SN photometry. From the history of these data, we identified J1258 as a new changing-state quasar (CSQ). We also performed follow-up spectroscopic observations in 2018 December and 2019 May using the 2 m telescope at the Nishi-Harima Astronomical Observatory. The results show that the continuum flux and the BEL flux decreased to about 50% of their peak. This indicates that J1258 present two changing states for the BEL flux and continuum flux. We argue that J1258’s variability, especially its brightening event, can be explained by the propagation of the heating front and the accretion disk state transitions based on the timescale and Eddington ratio variations. The estimated mass of the black hole of J1258 is about an order of magnitude larger than the CSQs found so far. Since both the changing timescale and the size of the accretion disk depend on the black hole mass, the J1258 brightening event can be interpreted as a scaled version of the variability in other CSQs. This suggests that samples of distant quasars with larger black hole masses may contain objects with longer and more severe variations.
A Printer’s Odd Plea to Reform Legal Pluralism in Khedival Egypt
Authors: Cheta Omar Youssef , Schwartz Kathryn A 
Published: November 2020

Abstract
In 1871, an Italian-Jewish printer published a peculiar Arabic treatise from Cairo. It promoted strengthening legal pluralism in Khedival Egypt by realigning laws there to accord with those of the Ottoman Empire and European states. Composed by the printer’s legal team, the treatise questioned how justice could be obtained if the extraterritorial privileges of European subjects and protégés were not guaranteed. The printer had been motivated by his own plight: a test of the Egyptian merchant courts left him mired in a catch-22, whereby he could either accept an imperfect verdict, or demand extralegal measures. Choosing the latter option, the treatise embodied his desperate bid to promote his cause. Its importance stems from its very existence. It gave form to the printer’s tricky predicament by grasping at different genres of legal writing; it made his personal story relevant to all by entering it into the public domain; and it audaciously called for strengthening Roman law in Egypt. While the document’s actual influence cannot be ascertained, it anticipated wider historical developments regarding the practice and conception of print and law in the modern Middle East.
Medication safety for children with medical complexity
Authors: Huth Kathleen , Vandecruys Patricia , Orkin Julia , Patel Hema 
Published: November 2020

Abstract
Due to advances in medical care and innovations in health technology, many children with life-limiting conditions are now living longer. These children are often referred to as ‘children with medical complexity (CMC)’, and they are characterized by chronic conditions, increased health care utilization, and technology dependence. Their complexity of care and inherent fragility lead to higher risk for medication errors, both in-community and in-hospital. High rates of care fragmentation, miscommunication, and polypharmacy in CMC increase opportunities for error, particularly as children transition between health care settings and practitioners. Data on the factors contributing to higher risk of medication errors in this population and how they can be effectively addressed are lacking. This practice point provides clinical guidance for health care professionals to ensure medication safety when caring for CMC, with focus on practical strategies for outpatient and inpatient care.
Le diagnostic et la prise en charge du sepsis grave chez le patient pédiatrique
Authors: Farrell Catherine A 
Published: November 2020

Abstract
Le sepsis est une réponse inflammatoire systémique à une infection présumée ou démontrée. Puisque c’est une cause importante de morbidité et de mortalité, plusieurs sociétés professionnelles ont lancé des initiatives ces dernières années, lesquelles ont débouché sur la rédaction de directives pour déceler le sepsis et le traiter rapidement. Les principaux aspects des directives les plus récentes sont résumés dans le présent point de pratique. Ils incluent la détection de changements à l’état clinique et aux signes vitaux qui doivent évoquer la possibilité de sepsis, tels que la fièvre, la tachycardie et des modifications de la perfusion périphérique, de même que la stabilisation initiale des voies respiratoires, de la respiration et de la circulation. Ils englobent également l’administration opportune d’une thérapie antimicrobienne, l’utilisation de bolus liquidiens et de médicaments vasoactifs et des considérations particulières chez les patients atteints de troubles médicaux sous-jacents, comme l’emploi de corticoïdes pour traiter une possible insuffisance surrénalienne découlant d’une suppression de l’axe hypothalamo-surrénalien. Deux modifications sont apportées aux directives précédentes, soit une réévaluation clinique après chaque bolus liquidien en raison de la crainte d’une surcharge hydrique et le remplacement de la dopamine comme agent vasoactif initial chez les patients pédiatriques hypotendus par de l’adrénaline ou de la noradrénaline en fonction du contexte clinique. Le présent point de pratique porte principalement sur la prise en charge du sepsis chez les nourrissons plus âgés, les enfants et les adolescents.
EP01 Post COVID-19 reactive arthritis
Authors: Waller Rosemary , Price Elizabeth , Carty Sara , Ahmed Azeem , Collins David 
Published: November 2020

Abstract

Case report - Introduction
We present what we believe to be the first reported case of post COVID-19 reactive arthritis, in a previously medically well 16-year-old with no past or family history of inflammatory arthritis.

Case report - Case description
Our patient was a previously medically fit 16-year-old of Caucasian origin who tested positive for COVID-19 in late March 2020. She developed with a 4-day illness with fever, cough, and myalgia from which she made a full and uncomplicated recovery.
Ten days later she developed a new erythematous itchy rash on her legs, trunk, and face and a progressive polyarthralgia affecting her MCPs, wrists, shoulders, hips, and knees. The rash typically lasted for 2 days at one site and was non-scarring. This was associated with a low-grade fever. There were no associated mouth ulcers, photosensitivity, alopecia, Raynaud’s, GI disturbance or respiratory symptoms. She had no relevant family history of autoimmunity, psoriasis or inflammatory bowel disease or travel history and had been prescribed no new medications.
On examination, she had an erythematous rash on the face in a non malar distribution. She had multiple tender joints without definite synovitis. Cardiovascular, respiratory, gastroenterology and neurological examinations were unremarkable.
Investigations revealed a normal full blood count and CRP&lt;1 with normal liver and renal function tests. Her urinalysis was unremarkable. Immunology was negative for ANA, ANCA and rheumatoid factor. Immunoglobulins were normal. Two weeks later her symptoms were fully resolved.

Case report - Discussion
Coronaviruses are single-stranded RNA viruses with nearly 30 strains recognised to infect humans. They induce both an innate and adaptive immune system response. It is hypothesised that a dysregulated innate system response, leading to a prolonged adaptive response triggers damaging inflammation and a potential cytokine storm. This is associated with poor outcome during primary viral infection. Variations in this immune response, with different underlying HLA genotypes could lead to other post infectious immune mediated phenomena, such as Paediatric Multisystem Inflammatory Syndrome - Temporally associated with COVID-19.
There is a European registry collating data about patients with known rheumatic diseases who are admitted with COVID-19. There is emerging data regarding Paediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS). There is a growing suggestion that a subgroup of patients is developing a COVID-19 associated post viral fatigue syndrome. We suggest that a registry to collect information on de novo autoimmune diseases presenting post COVID-19 is also commenced.

Case report - Key learning points
COVID-19 infection is associated with a wide variety of sequalae, including rheumatological ones.
Classic post viral Reactive arthritis has been seen. A registry to collect information on de novo autoimmune presentations would be highly informative.
Healthcare Costs, School Performance, and Health-related Quality of Life in Adolescence Following Psychotic Experiences in Preadolescence: A Longitudinal Cohort Study
Authors: Rimvall Martin Køster , Wolf Rasmus Trap , Olsen Else Marie , Skovgaard Anne Mette , Clemmensen Lars , Oxholm Anne Sophie , Verhulst Frank , Rask Charlotte Ulrikka , van Os Jim , Jeppesen Pia 
Published: November 2020

Abstract
Psychotic experiences (PEs) are common in the general population in preadolescence. The implications of PEs on socioeconomic outcomes, including educational attainment, are scarcely described. We aimed to estimate how preadolescent PEs were associated with later healthcare costs, school performance, and health-related quality of life (HRQoL) in adolescence. A total of 1607 preadolescents from the general population Copenhagen Child Cohort 2000 were assessed for PEs at age 11–12 years and followed up over 5 years using register-based data on mental and somatic healthcare costs, and school performance at age 16. Furthermore, HRQoL was assessed for a subsample of the children at age 16–17. We adjusted for perinatal and family sociodemographic adversities, prior parental mental illness and healthcare use, child IQ-estimate at age 11–12, and parent-rated general psychopathology of their child. PEs were associated with slightly poorer school performance. However, preadolescents with PEs more often reported HRQoL within the lowest 10th percentile (OR = 2.74 [95% CI 1.71–4.37]). Preadolescents who reported PEs had higher average total healthcare costs over the following 5 years. The costs for individuals with PEs were higher for mental healthcare services across primary to tertiary care, but not for somatic care. After adjustments, PEs remained independently associated with higher costs and poorer HRQoL, but not with poorer school performance. In conclusion, PEs are important in mental health screening of preadolescents and identify a group of young people with increased healthcare service-use throughout adolescence and who report poorer HRQoL in adolescence, over and above parent-rated general psychopathology of their child.
High levels of depressive symptoms among people with lower limb lymphoedema in Rwanda: a cross-sectional study
Authors: Semrau Maya , Davey Gail , Bayisenge Ursin , Deribe Kebede 
Published: November 2020

Abstract

Background
There is a growing body of evidence that mental distress and disorder are common among people with lower limb lymphoedema, although no research has been conducted on this subject in Rwanda.

Methods
This research was embedded within a mapping study to determine the national prevalence and geographical distribution of podoconiosis in Rwanda. Using a cluster sampling design, adult members of households within 80 randomly selected sectors in all 30 districts of Rwanda were first screened and 1143 patients were diagnosed with either podoconiosis (n=914) or lower limb lymphoedema of another cause (n=229). These 1143 participants completed the Patient Health Questionnaire (PHQ)-9 to establish the prevalence of depressive symptoms.

Results
Overall, 68.5% of participants reported depressive symptoms- 34.3% had mild depressive symptoms, 24.2% had moderate, 8.8% moderately severe and 1.2% severe depressive symptoms. The mean PHQ-9 score was 7.39 (SD=5.29) out of a possible 0 (no depression) to 27 (severe depression). Linear regression showed unemployment to be a consistently strong predictor of depressive symptoms; the other predictors were region (province), type of lymphoedema and, for those with podoconiosis, female gender, marital status and disease stage.

Conclusions
Levels of depressive symptoms were very high among people with lower limb lymphoedema in Rwanda, which should be addressed through holistic morbidity management and disability prevention services that integrate mental health, psychosocial and economic interventions alongside physical care.
A Hybrid Genome Assembly Resource for Podosphaera xanthii, the Main Causal Agent of Powdery Mildew Disease in Cucurbits
Authors: Polonio Álvaro , Díaz-Martínez Luis , Fernández-Ortuño Dolores , de Vicente Antonio , Romero Diego , López-Ruiz Francisco J. , Pérez-García Alejandro 
Published: November 2020

Podosphaera xanthii is the main causal agent of powdery mildew in cucurbits and, arguably, the most important fungal pathogen of cucurbit crops. Here, we present the first reference genome assembly for P. xanthii. We performed a hybrid genome assembly, using reads from Illumina NextSeq550 and PacBio Sequel S3. The short and long reads were assembled into 1,727 scaffolds with an N50 size of 163,173 bp, resulting in a 142-Mb genome size. The combination of homology-based and ab initio predictions allowed the prediction of 14,911 complete genes. Repetitive sequences comprised 76.2% of the genome. Our P. xanthii genome assembly improves considerably the molecular resources for research on P. xanthii−cucurbit interactions and provides new opportunities for further genomics, transcriptomics, and evolutionary studies in powdery mildew fungi. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Management of Isolated Anal Strictures in Crohn’s Disease
Authors: Lightner Amy L. , Click Benjamin , Yamamoto Takayuki , Spinelli Antonino , Kotze Paulo 
Published: November 2020

BACKGROUND:
Anorectal stricturing is a particularly morbid manifestation of Crohn’s disease resulting in a diminished quality of life related to pain, incontinence, and recurrent operative interventions.

OBJECTIVE:
To determine the role of medical therapy, endoscopic dilation, and surgical intervention for the treatment of isolated anorectal stricturing.

DATA SOURCES:
An organized search of MEDLINE, PubMed, EMBASE, Scopus, and the Cochrane Database of Collected Reviews was performed from January 1, 1990 through May 1, 2020.

STUDY SELECTION:
Full text papers which included management of isolated anorectal strictures in the setting of Crohn’s disease.

INTERVENTION(S):
Medical and surgical management.

MAIN OUTCOME MEASURES:
Symptomatic relief, need for proctocolectomy.

RESULTS:
Our search identified a total of 553 papers; after exclusion based on title (n = 430) and abstract (n = 47), 76 underwent full text review with 65 relevant to the management of anorectal strictures. A summary of the retrospective reports suggests that medical therapy can help control luminal inflammation, but fibrosis may ultimately set in resulting in a need for endoscopic or surgical intervention. Surgical options are limited in the anal canal due to inflammation and ulceration and concomitant perianal fistulizing disease. While fecal diversion can provide symptomatic relief, successful restoration of intestinal continuity remains uncommon and most patients ultimately undergo a total proctocolectomy with end ileostomy.

LIMITATIONS:
Limited literature published, all retrospective in nature.

CONCLUSIONS:
Despite significant advances in medical and surgical therapy in Crohn’s disease over the last decades, there is clearly an unmet need in the management of anorectal strictures in Crohn’s disease.