bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Vasculitis-Like Skin Eruption Associated With COVID-19
Authors: Geremia Nicholas , De Vito Andrea , Gunnella Susanna , Fiore Vito , Princic Elija , Panu Napodano Catello , Madeddu Giordano , Babudieri Sergio 
Published: September 2020

Abstract
Since the start of the SARS-CoV-2 outbreak, more than 4 million cases have been reported with almost 300,000 deaths. Commonly, the virus involves the respiratory system causing fever, cough, and dyspnea. On the contrary, cutaneous involvement has been infrequently reported. We described the case of a 72-year-old woman without a history of dermatologic diseases with COVID-19 who developed vasculitis-like skin eruptions. Because she has not received any treatment for COVID-19, we suggest that the dermatologic clinical picture was related to SARS-CoV-2.
Diabetes, insulin resistance, and asthma: a review of potential links
Authors: Wu Tianshi David 
Published: September 2020

Purpose of review
Disorders of glucose metabolism, including insulin resistance, prediabetes, and diabetes, have been identified as risk factors for worsened asthma. This review summarizes emerging evidence for their role as modifiable risk factors in asthma, including the potential benefit of diabetes medications on asthma outcomes.

Recent findings
Experimental studies show that hyperinsulinemia associated with insulin resistance is associated with airway smooth muscle proliferation and promotes contractility. Epidemiologic studies have identified a higher prevalence of glycemic dysfunction among those with severe and uncontrolled asthma, and longitudinal studies have associated prediabetes and diabetes with higher risk of asthma exacerbations. The potential benefits of thiazolidinediones (TZDs), glucagon-like peptide-1 agonists, and metformin being investigated in asthma, but thus far interventional studies of TZDs have reported null results. On the contrary, observational studies have inconsistently controlled for relevant confounders which leaves conclusions vulnerable to misattribution of relationships due to corelated metabolic disorders, including dyslipidemia.

Summary
Developing evidence suggests that disorders of glucose metabolism may be associated with worsening asthma. However, these conditions arise within a network of obesity-related metabolic diseases that may themselves worsen asthma. Few interventional trials have not identified a benefit, but data have been limited. Additional research is needed to define the potential independent impact of disorders of glucose metabolism in asthma.
Psychiatric Morbidity and Personality Characteristics of Detained Adolescents With Delinquent Behavior
Authors: Nasreldin Mohamed , Gohar Sherif M. , Abdel Samie Mai , Madbouly Nagwan 
Published: September 2020

Abstract
The current study was undertaken with the aim of assessing the psychopathological symptoms, personality profile, and hostility in detained adolescents with delinquent behavior. A cross-sectional analytical study was carried out on 50 admitted adolescent delinquents in correctional institutes in the Greater Cairo region of Egypt. Results for delinquent adolescents were compared with age-equivalent adolescents with no history of delinquency. Both groups were subjected to the Adolescent and Adult Psychological State Inventory, Eysenck Personality Questionnaire, Locus of Control scale, and the Hostility and Direction of Hostility Questionnaire (HDHQ). Results concluded that adolescents with delinquent behavior displayed increased rates of psychiatric disorders over the comparative group. Significantly higher scores on the psychoticism, neuroticism, extraversion, and psychopathic deviation subscales and the Locus of Control scale were evident among the adolescent delinquent group compared with their nondelinquent peers. The delinquent group obtained, in general, higher overall scores on the HDHQ questionnaire when compared with the nondelinquent adolescents, while also obtaining higher scores on the paranoid hostility subscale of HDHQ. Acting out hostility scores correlated positively with neuroticism and psychoticism in delinquents. Psychiatric morbidity, extraversion, neuroticism, psychoticism, and increased hostility were found to contribute as major psychosocial factors underlying the psychopathology in detained juvenile delinquents.
Telehealth and the Community SMI Population
Authors: Talley Rachel M. , Brunette Mary F. , Adler David A. , Dixon Lisa B. , Berlant Jeffrey , Erlich Matthew D. , Goldman Beth , First Michael B. , Koh Steve , Oslin David W. , Siris Samuel G. 
Published: September 2020

Abstract
The novel coronavirus pandemic and the resulting expanded use of telemedicine have temporarily transformed community-based care for individuals with serious mental illness (SMI), challenging traditional treatment paradigms. We review the rapid regulatory and practice shifts that facilitated broad use of telemedicine, the literature on the use of telehealth and telemedicine for individuals with SMI supporting the feasibility/acceptability of mobile interventions, and the more limited evidence-based telemedicine practices for this population. We provide anecdotal reflections on the opportunities and challenges for telemedicine drawn from our daily experiences providing services and overseeing systems for this population during the pandemic. We conclude by proposing that a continued, more prominent role for telemedicine in the care of individuals with SMI be sustained in the post-coronavirus landscape, offering future directions for policy, technical assistance, training, and research to bring about this change.
Quality and Safety in Healthcare, Part LXXII
Authors: Harolds Jay A. 
Published: September 2020

Abstract
Healthcare credentialing is the methodology used by an organization to obtain and validate a practitioner’s credentials, typically to participate in patient care. Privileging is the process by which the designated individuals in the healthcare organization evaluate the credentials, as well as the performance of the individual to determine that the provider is worthy to have certain privileges in the institution to contribute to the care of patients. The healthcare institution must have appropriate processes to ensure that providers continue to give excellent care in order to maintain privileges. There must also be procedures in place for remediation and revocation of privileges when necessary, as well as an appeals procedure. In addition, there should be provisions for privileging of temporary workers and for privileging in emergency situations.
18F-FDG PET/CT Findings in a Patient With Neurosarcoidosis
Authors: Chen Xueqi , Chen Guoqian , Fu Zhanli , Li Qian 
Published: September 2020

Abstract
A 58-year-old woman experienced 4 months of headache, fatigue, and depression, as well as 1 week of confusion and hallucinations. 18F-FDG PET/CT showed numerous hypermetabolic lesions in the pituitary gland and stalk, dura mater, glossopharyngeal nerve, and cauda equina, as well as in cervical and mediastinal lymph nodes. Surgical biopsy of the mediastinal lymph node confirmed the diagnosis of sarcoidosis. The follow-up 18F-FDG PET/CT, performed at the eighth month after the treatment of glucocorticoids and immunosuppressive agents, demonstrated complete remission of the previous hypermetabolic lesions.
Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease
Authors: Shin Hae-Won , Chung Seok Jong , Lee Sangwon , Cha Jungho , Sohn Young H. , Yun Mijin , Lee Phil Hyu 
Published: September 2020

PurposeThe aim of this study was to investigate the association between autonomic dysfunction and striatal dopamine depletion or metabolic changes in de novo Parkinson disease (PD).MethodsBased on the Composite Autonomic Severity Score (CASS), patients with de novo PD were classified into PD with (PD-AUT+) and without autonomic dysfunction (PD-AUT−) groups. We compared the dopamine transporter (DAT) availability in the striatum by quantitatively measuring18F-FP-CIT PET between both groups. We also assessed the association between DAT availability and the CASS. In addition, we compared regional uptake in early-phase images of18F-FP-CIT PET as well as cortical thickness between the PD-AUT+ and PD-AUT− groups.ResultsThe PD-AUT+ group had significantly lower DAT availability in all striatal subregions than did the PD-AUT− group. The total CASS was significantly correlated with DAT availability in all striatal subregions. In addition, the subscores of the adrenergic component were correlated with DAT availability in all striatal subregions. The subscores of the cardiovagal component were negatively correlated with DAT availability in the caudate and ventral striatum. In early-phase18F-FP-CIT PET, the PD-AUT+ group exhibited decreased regional perfusion in the parieto-occipital areas and increased regional perfusion in the pallidothalamic, pontocerebellar, inferior frontal, and primary motor areas compared with the PD-AUT− group. There were no regions of different cortical thickness between the PD groups.ConclusionsThe present study revealed that autonomic dysfunction is closely linked to striatal dopamine depletion and prominent PD-related perfusion patterns in de novo PD, suggesting a greater pathological burden in patients with dysautonomia.
Peptide Receptor Radionuclide Therapy in Patients With Differentiated Thyroid Cancer
Authors: Lee Dong Yun , Kim Yong-il 
Published: September 2020

Purpose
As patients with progressive medullary thyroid cancer (MTC) and radioiodine-refractory metastatic differentiated nonmedullary thyroid cancer (DTC) have poor prognoses and present therapeutic challenges, peptide receptor radionuclide therapy (PRRT) targeting the somatostatin receptor provides a promising option. This meta-analysis evaluated the therapeutic effects and outcomes of PRRT in differentiated thyroid cancer.

PATIENTS AND METHODS
PUBMED, EMBASE, CINAHL, SCOPUS, and COCHRANE were systematically searched using appropriate key words. The primary therapeutic effect was the radiological response after PRRT, and the objective response rate (ORR) and disease control rate (DCR) were identified in MTC and DTC, respectively. The outcome of serious adverse events (grade 3 or 4), additional therapeutic effects of 18F-FDG PET/CT and biochemical (calcitonin and thyroglobulin) responses, and radionuclides for PRRT were assessed as subgroup analyses. The parameters were generated as pooled proportions.

Results
Eleven articles with 165 patients were included (98 patients with MTC and 67 patients with DTC). PRRT achieved pooled proportions of ORR in 8.53% to 15.61%, DCR in 53.95% to 59.99%, and serious adverse events in 2.79% to 2.82% in MTC and DTC patients. 18F-FDG PET/CT and biochemical responses revealed similar results as the radiological response. 177Lu-based PRRT (ORR, 11.48%–24.52%; DCR, 61.47%–67.26%) showed better therapeutic effects than 90Y-based PRRT (ORR, 6.98%–13.82%; DCR, 50.86%–57.29%).

Conclusions
This meta-analysis suggests that PRRT could be a potential and safe strategy for MTC and DTC. In particular, PRRT with 177Lu exhibited improved therapeutic effects relative to PRRT with 90Y.
18F-NaF Uptake in Breast Cancer
Authors: Liu Huipan , Liu Lin , Fu Wenhui , Chen Yue 
Published: September 2020

Abstract
A 55-year-old woman with back pain underwent 18F-NaF PET/CT study to evaluate bone metastases from newly diagnosed breast cancer. Multiple foci of increased tracer uptake indicating osteoblastic metastases were noted in cervical and thoracic vertebrae. Unexpectedly, breast cancer also revealed increased NaF activity.
Adrenal and Bone Metastases as the Initial Presentation of Endometrial Carcinoma Diagnosed by 18F-FDG PET/CT
Authors: Su Minggang , Sun Jiangming , Fan Qiuping , Tian Rong 
Published: September 2020

Abstract
Adrenal and bone metastases as the initial presentation of endometrial carcinoma are rare. We report a case of endometrial carcinoma in a 47-year-old woman with initial manifestation as right chest wall pain, which was suspected as adrenal cortical carcinoma with rib metastasis after diagnostic CT scan. However, uterine and pelvic bone lesions were revealed by staging FDG PET/CT. Eventually, endometrial carcinoma with adrenal and bone metastases was confirmed pathologically.
Is It Time to Introduce PET/CT in Rectal Cancer Guidelines?
Authors: Maffione Anna Margherita , Montesi Giampaolo , Caroli Paola , Colletti Patrick M. , Rubello Domenico , Matteucci Federica 
Published: September 2020

Abstract
At the moment, international guidelines for rectal cancer suggest to consider 18F-FDG PET/CT scan in a few conditions: (1) at disease presentation in case of suspected or proven metastatic synchronous adenocarcinoma with potentially curable M1 disease; (2) in the recurrence workup for serial carcinoembryonic antigen level elevation; (3) in the recurrence workup with metachronous metastases documented by CT, MRI, or biopsy; (4) in case of strong contraindication to IV contrast agent administration; and (5) to evaluate an equivocal finding on a contrast-enhanced CT or MRI. PET/CT is not indicated in the follow-up or surveillance of rectal cancer. On the other hand, an attentive evaluation of the literature shows that PET/CT may also be used in some circumstances with significant levels of diagnostic accuracy. This review article aims to emphasize differences between current international guidelines and scientific literature in the role of PET/CT in rectal cancer.
18F-FDG Uptake in a Mesonephric Carcinoma
Authors: Luong Thien Vinh , Lindegaard Jacob Christian , Donskov Frede , Mejlgaard Else , Bouchelouche Kirsten 
Published: September 2020

Abstract
We present the case of a 39-year-old woman with vaginal bleeding and abdominal pain. An 18F-FDG PET/CT showed high 18F-FDG uptake in a tumor in the pouch of Douglas, in 3 lymph nodes in the pelvis, and in the left tuber ischiadicum. Biopsies revealed a mesonephric carcinoma with metastases. Six series of empiric chemotherapy with carboplatin, paclitaxel, and bevacizumab were not sufficient to treat the cancer, and checkpoint immunotherapy with nivolumab and ipilimumab was initialized.
Ureteral Metastasis From Prostate Cancer
Authors: Chaussé Guillaume , Skinnider Brian , Crook Juanita , Black Peter , Abikhzer Gad , Probst Stephan 
Published: September 2020

Abstract
A 72-year-old man with a history of prostate adenocarcinoma initially managed by radical prostatectomy and salvage radiation therapy underwent resection of a left vas deferens recurrence identified on PSMA PET. Despite an initial response, PSA failed to fall below 3.5 ng/L, prompting re-evaluation with PSMA PET/CT: a left distal hydroureter with presumed physiologic urine activity remains despite diuretic administration. Upon scrutiny of the prior PSMA PET/CT and diagnostic CTs, the distal ureteral uptake matched a subtle circumferential area of enhancing mild ureteral thickening. Pathological review after left uretectomy confirmed metastatic prostate cancer.
18F-FDG PET/CT in Hodgkin Lymphoma With Unsuspected COVID-19
Authors: Boulvard Chollet Xavier L.E. , Romero Robles Leonardo G. , Garrastachu Puy , Cabrera Villegas Antonio , Albornoz Almada M. Clara , Colletti Patrick M. , Rubello Domenico , Ramírez Lasanta Rafael , Delgado Bolton Roberto C. 
Published: September 2020

Abstract
We present an asymptomatic 70-year-old man referred for an 18F-FDG PET/CT for initial staging of a Hodgkin lymphoma. 18F-FDG PET/CT showed bilateral cervical lymphadenopathy (stage II). Incidentally, the CT demonstrated bilateral ground-glass opacities with low-grade 18F-FDG activity. CT findings were suspicious for COVID-19 pneumonitis. The COVID-19 reverse transcriptase polymerase chain reaction (RT-PCR) examination result was negative. Given the high clinical suspicion for COVID-19, the patient was isolated and repeat RT-PCR was positive at 72 hours. RT-PCR may be falsely negative in early COVID-19 disease, even with positive CT findings.
Three Cases of Diffuse, Intense Stomach Uptake on DOTATATE PET
Authors: Auerbach Martin S. , Pisegna Joseph R. , Kim Stephen , Yu Run 
Published: September 2020

Abstract
Incidental tracer uptake on DOTATATE PET is increasingly encountered in clinical practice. We describe 3 patients with suspected or known neuroendocrine tumor who were found to have diffuse and intense stomach uptake on DOTATATE PET. All patients underwent esophagogastroduodenoscopy and/or endoscopic ultrasound; the cause of the stomach uptake was attributed to proton-pump inhibitor use, chronic gastritis, and gastrinoma, respectively. These 3 cases highlight that diffuse and intense stomach DOTATATE uptake can be a benign finding probably attributed to proton-pump inhibitor use, chronic gastritis, or gastrinoma.
Hepatic Schwannoma on 18F-FDG PET/CT
Authors: Liu Yachao , Xu Baixuan 
Published: September 2020

Abstract
Schwannoma is a slow-growing benign tumor, which originates from Schwann cells and is usually asymptomatic. The most common sites of schwannomas are the head, neck, and extremities. However, a schwannoma located in the liver is extremely rare. Here, we report a 53-year-old woman with a hepatic lesion accidentally found by ultrasound. It was highly suggestive of hepatic cholangiocarcinoma by MRI. 18F-FDG PET/CT could not exclude hepatic malignant tumor due to its high metabolism. Finally, it was confirmed as hepatic schwannoma by postoperative pathology.
Multifocal Interdigitating Dendritic Cell Sarcoma Demonstrated on FDG PET/CT Imaging
Authors: Bai Xia , Wang Xiangcheng , Wang Xuemei 
Published: September 2020

Abstract
Interdigitating dendritic cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating dendritic cell sarcoma in a 30-year-old woman.
The Imaging Features and Clinical Associations of a Novel Tau PET Tracer—18F-APN1607 in Alzheimer Disease
Authors: Hsu Jung-Lung , Lin Kun-Ju , Hsiao Ing-Tsung , Huang Kuo-Lun , Liu Chi-Hung , Wu Hsiu-Chuan , Weng Yi-Ching , Huang Chu-Yun , Chang Chiung-Chih , Yen Tzu-Chen , Higuchi Makoto , Jang Ming-Kuei , Huang Chin-Chang 
Published: September 2020

Purpose of the Report
In vivo tau PET imaging could help clarify the spatial distribution of tau deposition in Alzheimer disease (AD) and aid in the differential diagnosis of tauopathies. To date, there have been no in vivo 18F-APN1607 tau PET studies in patients with AD.

Methods
We applied tau tracer in 12 normal controls (NCs) and 10 patients in the mild to moderate stage of probable AD. Detailed clinical information, cognitive measurements, and disease severity were documented. Regional SUV ratios (SUVRs) from 18F-AV-45 (florbetapir), 18F-APN1607 PET images, and regional gray matter (GM) atrophic ratios were calculated for further analysis.

Results
Quantitative analyses showed significantly elevated SUVRs in the frontal, temporal, parietal, occipital lobes, anterior and posterior cingulate gyri, precuneus, and parahippocampal region (all P’s < 0.01) with medium to large effect sizes (0.44–0.75). The SUVRs from 18F-APN1607 PET imaging showed significant correlations with the Alzheimer’s Disease Assessment Scale (ADAS-cog) scores (all P’s < 0.01) and strong correlation coefficients (R
2 ranged from 0.54 to 0.68), even adjusted for age and sex effects. Finally, the SUVRs from 18F-APN1607 PET imaging of the parahippocampal region showed rapid saturation as the ADAS-cog scores increased, and the SUVRs of the posterior cingulate gyrus and the temporal, frontal, parietal, and occipital regions slowly increased. The combined SUVRs from amyloid, tau PET, and regional GM atrophic ratio showed regional specific patterns as the ADAS-cog scores increased.

Conclusions
Our findings suggest that the 18F-APN1607 tau tracer correlated well with cognitive changes and demonstrated the spatial pattern of amyloid, tau deposition, and GM atrophy in the progression of AD.
Peptide Receptor Radionuclide Therapy as First-Line Systemic Treatment in Advanced Inoperable/Metastatic Neuroendocrine Tumors
Authors: Satapathy Swayamjeet , Mittal Bhagwant Rai , Sood Ashwani , Sood Apurva , Kapoor Rakesh , Gupta Rajesh 
Published: September 2020

Purpose
Advanced inoperable/metastatic neuroendocrine tumors (NETs) pose a therapeutic challenge with limited treatment options. Peptide receptor radionuclide therapy (PRRT), being specific in targeting the somatostatin receptors, is a promising and viable option in this setting. In this study, we intended to evaluate the role of PRRT as the first-line systemic therapy in advanced inoperable/metastatic NETs.

Methods
Data of consecutive patients of advanced inoperable/metastatic NETs treated with first-line 177Lu-DOTATATE at our center, from September 2012 to August 2019, were collected and analyzed.

Results
Forty-five patients (median age, 50 years; range, 14–72 years) with treatment-naive advanced NETs received a median cumulative dose of 27 GBq (range, 13.3–41.3 GBq; over 2–7 cycles) 177Lu-DOTATATE and 1250 mg/m2 capecitabine from days 0 to 14 of each PRRT cycle. Three patients were lost to follow-up, 2 had nonmeasurable lesions on CT, and hence, radiological response using Response Evaluation Criteria in Solid Tumors version 1.1 could be assessed in 40 patients. Twelve of 40 patients (30%) showed a partial response, whereas stable disease was observed in 22 of 40 patients (55%). Disease progression was limited to 6 of 40 patients (15%). Treatment-related adverse effects were minimal with grade 3/4 anemia, leukopenia, neutropenia, and hepatotoxicity observed in 2%, 2%, 4%, and 4% of the patients, respectively. Median progression-free survival was 48 months (95% confidence interval, 34.7–61.3 months).

Conclusions
Our results indicate the efficacy and safety of first-line PRRT in advanced NETs. Future randomized trials, comparing PRRT and somatostatin analogs in treatment-naive patients, are required to identify the definite sequence of treatment options for these patients.
A Rare Case of Solitary Pituitary Metastasis From Spitzoid Melanoma Detected by FDG PET/CT
Authors: Annunziata Salvatore , Annovazzi Alessio , Pasqualoni Rosella , Bergomi Serenella , Sciuto Rosa 
Published: September 2020

Abstract
A 33-year-old man had a diagnosis of a spitzoid melanoma by dorsal skin biopsy. During the oncological follow-up, patient underwent whole-body FDG PET/CT for restaging purpose. FDG PET/CT showed a large necrotic mass of the pituitary gland, subsequently confirming a solitary pituitary metastasis from spitzoid melanoma.
PET/CT of COVID-19 as an Organizing Pneumonia
Authors: Alonso Sanchez Jaime , García Prieto Julia , Galiana Morón Alvaro , Pilkington-Woll John Patrick 
Published: September 2020

Abstract
An 85-year-old woman with history of melanoma is referred for a follow-up 18F-FDG PET/CT. 18F-FDG PET/CT scan showed bilateral and peripheral ground-glass opacities in upper and lower pulmonary lobes surrounded by consolidations of crescent shape with increased FDG uptake, findings compatible with organizing pneumonia. Following further inquiry, the patient reported low-grade fever, sore throat, and fatigue for the past 6 days. Because of the ongoing COVID-19 pandemic, the patient was tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which resulted positive.