bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting Slow Slip Events From Seafloor Pressure Data Using Machine Learning
Authors: He Bing , Wei Meng , Watts D. Randolph , Shen Yang 
Published: May 2020

AbstractDetecting slow slip events (SSEs) at offshore subduction zones is important to understand the slip behavior on offshore subduction megathrusts, where tsunamis can be generated. The most widely used method to detect SSEs is to measure the vertical seafloor deformation caused by SSEs using seafloor pressure data. However, due to the small signal‐to‐noise ratio and instrumental drift, such detection is very difficult. In this study, we trained a machine learning model using synthetic data to detect SSEs and applied it to real pressure data in New Zealand between 2014 and 2015. Our method detected five events, two of which are confirmed by the onshore GPS records. Besides, our model performs better than the traditional matched filter method. We conclude that machine learning could be used to detect SSEs in real seafloor pressure data. The method can be applied to other regions, especially where near trench GPS is not available.
Formation and Evolution of the Large‐Scale Magnetic Fields in Venus' Ionosphere: Results From a Three Dimensional Global Multispecies MHD Model
Authors: Ma Yingjuan , Toth Gabor , Nagy Andrew , Luhmann Janet , Russell Christopher 
Published: May 2020

AbstractLarge‐scale magnetic fields have been observed in Venus' ionosphere by both the Pioneer Venus Orbiter (PVO) and Venus Express spacecraft. In this study, we examine the formation and evolution of the large‐scale magnetic field in the Venus ionosphere using a sophisticated global multispecies Magnetohydrodynamics (MHD) model that has been developed for Venus (Ma et al., 2013, https://doi.org/10.1029/2012JA018265). A time‐dependent model run is performed under varying solar wind dynamic pressure. Based on model results, we find that (1) the initial response of the induced magnetosphere is fast (~min), (2) a large‐scale magnetic field gradually forms in the ionosphere when the solar wind dynamic pressure suddenly exceeds the ionospheric thermal pressure, (3) both the penetration and decay of the large‐scale magnetic field in the ionosphere are slow (~hr), and (4) the ion escape rate has a nonlinear response to the change of solar wind dynamic pressure.
Assessing the Roughness Properties of Circumpolar Lunar Craters: Implications for the Timing of Water‐Ice Delivery to the Moon
Authors: Deutsch Ariel N. , Head James W. , Neumann Gregory A. , Kreslavsky Mikhail A. , Barker Michael K. 
Published: May 2020

AbstractThe roughness properties of impact craters are valuable indicators of crater degradation and can provide insight into crater ages. We evaluate the roughness of lunar craters from different geologic eras, confirming that young, Copernican craters are distinctly rougher than older craters. We evaluate the potential age of small (less than ~15 km) craters that are thought to host surface ice by quantifying the roughness inside these craters, as well as outside. Interior roughness may be subdued by slope processes or the presence of volatiles. The distribution of ice‐bearing craters is skewed toward roughness values higher than those of pre‐Imbrian craters, although no ice‐bearing craters are within the Copernican‐only domain in roughness space. All of the 15 rough, permanently shadowed craters that are found within the Copernican‐only domain lack water‐ice detections, suggesting that either ice has not been delivered to these young craters or that it has since been destroyed.
Robust Future Changes in Meteorological Drought in CMIP6 Projections Despite Uncertainty in Precipitation
Authors: Ukkola Anna M. , De Kauwe Martin G. , Roderick Michael L. , Abramowitz Gab , Pitman Andrew J. 
Published: May 2020

AbstractQuantifying how climate change drives drought is a priority to inform policy and adaptation planning. We show that the latest Coupled Model Intercomparison Project (CMIP6) simulations project coherent regional patterns in meteorological drought for two emissions scenarios to 2100. We find robust projected changes in seasonal drought duration and frequency (robust over >45% of the global land area), despite a lack of agreement across models in projected changes in mean precipitation (24% of the land area). Future drought changes are larger and more consistent in CMIP6 compared to CMIP5. We find regionalized increases and decreases in drought duration and frequency that are driven by changes in both precipitation mean and variability. Conversely, drought intensity increases over most regions but is not simulated well historically by the climate models. The more robust projections of meteorological drought compared to mean precipitation in CMIP6 provides significant new opportunities for water resource planning.
Fingerprints of Anthropogenic Influences on Vegetation Change Over the Tibetan Plateau From an Ecohydrological Diagnosis
Authors: Jin Zheng , You Qinglong , Mu Mu , Sun Guodong , Pepin Nick 
Published: May 2020

AbstractVegetation cover exerts a strong control on land‐atmosphere interactions. To quantify the relative effects of external forcing (climate change) versus internal forcing (anthropogenic activity) on recent vegetation change over the Tibetan Plateau (TP), we apply an ecohydrological diagnostic framework, developed from earlier work. We compare vegetation change during 1986–2015 based on NDVI (Normalized Difference Vegetation Index) data with changes in environmental conditions (European Centre for Medium‐Range Weather Forecasts Reanalysis 5th generation, ERA5). Results show that external forcing is the dominant factor behind significant vegetation change over the southeastern TP during 1986–2015. In the area with significant vegetation changing, 60.5%/41.5% of pixels have experienced a respective wetting/drying of climate, which in turn has supported greening/browning during 1986–2005/1996–2015. However, during the greening/browning transition in the latter period, the proportion of internal forcing on browning increased from 5.62% to 19.4%, indicating that anthropogenic factors are playing an increasingly role on impacting vegetation change in recent decades.
A Control of ENSO Transition Complexity by Tropical Pacific Mean SSTs Through Tropical‐Subtropical Interaction
Authors: Fang Shih‐Wei , Yu Jin‐Yi 
Published: May 2020

AbstractEl Niño–Southern Oscillation (ENSO) transitions from one event to another in complex ways. Using observational analyses and forced atmospheric model experiments, we show that a preceding ENSO event can activate a subtropical Pacific forcing mechanism to trigger another ENSO event during the following year. These tropical‐subtropical Pacific interactions result in a cyclic ENSO transition if the two ENSO events are of opposite signs or a multiyear ENSO transition if they are of the same sign. The preceding ENSO event should excite deep convections in the tropical Pacific in order to activate the subtropical Pacific mechanism. This requirement enables mean temperatures in the cold tongue and warm pool to respectively control how easily the cyclic and multiyear transitions can occur. A future warmer tropical Pacific is projected to decrease the frequency of occurrence of multiyear ENSO transitions but increase the occurrence of cyclic ENSO transitions.
Sea Ice Retreat Contributes to Projected Increases in Extreme Arctic Ocean Surface Waves
Authors: Casas‐Prat Mercè , Wang Xiaolan L. 
Published: May 2020

AbstractThe projected changes and trends in the regional annual and monthly maxima of the significant wave height (Hs) in the Arctic Ocean are studied using wave simulations derived from the CMIP5 (Coupled Model Intercomparison Project Phase 5) climate simulations for 1979–2005 and 2081–2100 periods. Under the RCP8.5 scenario, the regional annual maximal Hs increases on average up to ∼3 cm/year, or >0.5%/year, relative to the 1986–2005 climatological value, in many Arctic areas (and up to 0.8%/year in the east side of the Arctic Ocean). While strong winds need to occur for large waves to develop, the changes in wind speed alone cannot explain the increases in the regional maximal Hs. Sea ice retreat also plays an important role by increasing fetch to promote wave growth, thereby contributing notably to the projected increase in wave height. It also contributes to increasing the probability of strong winds over the widening ice‐free waters.
Nonstationary Quasiperpendicular Shock and Ion Reflection at Mars
Authors: Madanian Hadi , Schwartz Steven J. , Halekas Jasper S. , Wilson Lynn B. 
Published: May 2020

AbstractCollisionless shocks in space plasma are regions of heating and acceleration of charged particles and dissipation of kinetic energy. These accelerated particles are the source of electromagnetic emissions from supernova remnants and other astrophysical structures. At high Mach numbers, shocks can be inherently nonstationary and exhibit modulated energy transfer and recurring plasma compression areas in the form of reformation. We use data from the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft to study reformation of the Martian bow shock, which has a relatively high curvature compared to that at Earth, and the upstream solar wind is often mass loaded with a population of pickup ions. We show evidence of ion reflection effects in reformation of a supercritical quasiperpendicular shock.
Contribution of Wave Setup to Projected Coastal Sea Level Changes
Authors: Melet A. , Almar R. , Hemer M. , Le Cozannet G. , Meyssignac B. , Ruggiero P. 
Published: May 2020

AbstractAlong open coasts, wind waves are a key driver of coastal changes and can be major contributors to coastal hazards. Wind wave characteristics are projected to change in response to climate change, notably due to changes in atmospheric circulation patterns and the associated surface winds. Here, a first‐order estimate of projected 20‐yr mean wave setup changes, excluding extreme events and subannual variability, is provided for sandy beaches along most of the world's coastline over the middle and end of the 21st century. Calculations are based on an ensemble of wave model projections under the representative concentration pathways (RCP) 8.5 and on empirical formulations for wave setup. Projected wave setup changes are compared to other contributors currently accounted for in regional sea level projections to extend existing projections of 21st century coastal sea level changes. Projected wave setup changes exhibit a clear spatial heterogeneity and mostly average out at global scale. However, at regional or local scale, wave setup changes are a small yet nonnegligible contributor to total coastal sea level 20‐yr mean changes (which include global mean sea level rise, GMSLR) over the middle and end of the 21st century. Wave setup can be a substantial contributor to local departures of coastal sea level changes from GMSLR. Wave setup changes should therefore be included in projections of regional patterns of coastal sea level changes. The reported long‐term changes in wave setup also advocate for the inclusion of nonstationary wave contributions to projected regional patterns of coastal sea level changes, including for studies on extreme events.
Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial
Authors: Wong Nichol M. L. , Findon James L. , Wichers Robert H. , Giampietro Vincent , Stoencheva Vladimira , Murphy Clodagh M. , Blainey Sarah , Ecker Christine , Murphy Declan G. , McAlonan Grainne M. , Daly Eileen 
Published: May 2020

AbstractEmotion processing—including signals from facial expressions—is often altered in individuals with autism spectrum disorder (ASD). The biological basis of this is poorly understood but may include neurochemically mediated differences in the responsivity of key ‘limbic’ regions (including amygdala, ventromedial prefrontal cortex (vmPFC) and nucleus accumbens (NAc)). Emerging evidence also suggests that ASD may be a disorder of brain temporal dynamics. Moreover, serotonin (5-HT) has been shown to be a key regulator of both facial-emotion processing and brain dynamics, and 5-HT abnormalities have been consistently implicated in ASD. To date, however, no one has examined how 5-HT influences the dynamics of facial-emotion processing in ASD. Therefore, we compared the influence of 5-HT on the responsivity of brain dynamics during facial-emotion processing in individuals with and without ASD. Participants completed a facial-emotion processing fMRI task at least 8 days apart using a randomised double-blind crossover design. At each visit they received either a single 20-mg oral dose of the selective serotonin reuptake inhibitor (SSRI) citalopram or placebo. We found that citalopram (which increases levels of 5-HT) caused sustained activation in key limbic regions during processing of negative facial emotions in adults with ASD—but not in neurotypical adults. The neurotypical adults’ limbic response reverted more rapidly to baseline following a 5-HT-challenge. Our results suggest that serotonergic homoeostatic control of the temporal dynamics in limbic regions is altered in adults with ASD, and provide a fresh perspective on the biology of ASD.
Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas
Authors: Sielska Malgorzata , Przanowski Piotr , Pasierbińska Maria , Wojnicki Kamil , Poleszak Katarzyna , Wojtas Bartosz , Grzeganek Dominika , Ellert-Miklaszewska Aleksandra , Ku Min-Chi , Kettenmann Helmut , Kaminska Bozena 
Published: May 2020

Abstract
Background
Malignant tumours release factors, which attract myeloid cells and induce their polarisation to pro-invasive, immunosuppressive phenotypes. Brain-resident microglia and peripheral macrophages accumulate in the tumour microenvironment of glioblastoma (GBM) and induce immunosuppression fostering tumour progression. Macrophage colony stimulating factors (CSFs) control the recruitment of myeloid cells during peripheral cancer progression, but it is disputable, which CSFs drive their accumulation in gliomas.

Methods
The expression of CSF2 (encoding granulocyte-macrophage colony stimulating factor) was determined in TCGA datasets and five human glioma cell lines. Effects of stable CSF2 knockdown in glioma cells or neutralising CSF2 or receptor CSF2Rα antibodies on glioma invasion were tested in vitro and in vivo.

Results
CSF2 knockdown or blockade of its signalling reduced microglia-dependent glioma invasion in microglia-glioma co-cultures. CSF2-deficient human glioma cells encapsulated in cell-impermeable hollow fibres and transplanted to mouse brains, failed to attract microglia, but stimulated astrocyte recruitment. CSF2-depleted gliomas were smaller, attracted less microglia and macrophages, and provided survival benefit in tumour-bearing mice. Apoptotic microglia/macrophages were detected in CSF2-depleted tumours.

Conclusions
CSF2 is overexpressed in a subset of mesenchymal GBMs in association with high immune gene expression. Tumour-derived CSF2 attracts, supports survival and induces pro-tumorigenic polarisation of microglia and macrophages.
Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer
Authors: Jiang Yu-Xin , Siu Michelle Kwan-Yee , Wang Jing-Jing , Mo Xue-Tang , Leung Thomas Ho-Yin , Chan David Wai , Cheung Annie Nga-Yin , Ngan Hextan Yuen-Sheung , Chan Karen Kar-Loen 
Published: May 2020

Abstract
Background
Ovarian cancer is characterised by frequent recurrence due to persistent presence of residual cancer stem cells (CSCs). Here, we identify and characterise tumour subsets from ascites-derived tumour cells with stemness, metastasis and metabolic switch properties and to delineate the involvement of pyruvate dehydrogenase kinase 4 (PDK4) in such process.

Methods
Ovarian cancer cells/cell lines derived from ascites were used for tumourspheres/ALDH+CD44+ subset isolation. The functional roles and downstream signalling of PDK4 were explored. Its association with clinical outcome of ovarian cancer was analysed.

Results
We demonstrated enhanced CSC characteristics of tumour cells derived from ovarian cancer ascites, concomitant with ALDH and CD44 subset enrichment and high PDK4 expression, compared to primary tumours. We further showed tumourspheres/ALDH+CD44+ subsets from ascites-derived tumour cells/cell lines with CSC properties and enhanced glycolysis. Clinically, PDK4 expression was correlated with aggressive features. Notably, blockade of PDK4 in tumourspheres/ALDH+CD44+ subsets led to inhibition of CSC characteristics, glycolysis and activation of STAT3/AKT/NF-κB/IL-8 (signal transducer and activator of transcription 3/protein kinases B/nuclear factor-κB/interleukin-8) signalling. Conversely, overexpression of PDK4 in ALDH−CD44– subsets exerted the opposite effects.

Conclusion
Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastatic and metabolic switch properties via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling, suggesting PDK4 as a viable therapeutic molecular target for ovarian cancer management.
Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study
Authors: Welch Catherine A. , Sweeting Michael J. , Lambert Paul C. , Rutherford Mark J. , Jack Ruth H. , West Douglas , Adlam David , Peake Michael 
Published: May 2020

Abstract
Background
The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased.

Methods
Cancer registry data consisted of English patients diagnosed with NSCLC from 2012 to 2016. Linked hospital records identified CVD comorbidities. We investigated resection rate variation by geographical region using funnel plots; resection and death rates using time-to-event analysis. We modelled an increased propensity for resection in regions with the lowest resection rates and estimated survival change.

Results
Among 57,373 patients with Stage 1−3A NSCLC, resection rates varied considerably between regions. Patients with CVD comorbidity had lower resection rates and higher mortality rates. CVD comorbidity explained only 1.9% of the variation in resection rates. For every 100 CVD comorbid patients, increasing resection in regions with the lowest rates from 24 to 44% would result in 16 more patients resected and alive after 1 year and two fewer deaths overall.

Conclusions
Variation in regional resection rate is not explained by CVD comorbidities. Increasing resection in patients with CVD comorbidity to the levels of the highest resecting region would increase 1-year survival.
Delayed breast cancer diagnosis after repeated recall at biennial screening mammography: an observational follow-up study from the Netherlands
Authors: Lameijer Joost R. C. , Voogd Adri C. , Pijnappel Ruud M. , Setz-Pels Wikke , Broeders Mireille J. , Tjan-Heijnen Vivianne C. G. , Duijm Lucien E. M. 
Published: May 2020

Abstract
Background
Delay in detection of breast cancer may worsen tumour characteristics, with progression of tumour size and a higher risk of metastatic lymph nodes. The purpose of this study was to investigate delayed breast cancer diagnosis after repeated recall for the same mammographic abnormality at screening.

Methods
This was a retrospective study performed in two cohorts of women enrolled in a mammography screening programme in the Netherlands. All women aged 50−75 who underwent biennial screening mammography either between January 1, 1997 and December 31, 2006 (cohort 1) or between January 1, 2007 and December 31, 2016 (cohort 2) were included.

Results
The cohorts showed no difference in proportions of women with delayed breast cancer diagnosis of at least 2 years (2.2% versus 2.8%, P = 0.29). Most delays were caused by incorrect BI-RADS classifications after recall (74.2%). An increase in mean tumour size was seen when comparing sizes at initial false-negative recall and at diagnosis of breast cancer (P < 0.001).

Conclusions
The proportion of women with a long delay in breast cancer confirmation following repeated recall at screening mammography has not decreased during 20 years of screening. These delays lead to larger tumour size at detection and may negatively influence prognosis.
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion
Authors: Hornigold Nick , Dunn Karen R. , Craven Rachel A. , Zougman Alexandre , Trainor Sebastian , Shreeve Rebecca , Brown Joanne , Sewell Helen , Shires Michael , Knowles Margaret , Fukuwatari Tsutomu , Maher Eamonn R. , Burns Julie , Bhattarai Selina , Menon Mini , Brazma Alvis , Scelo Ghislaine , Feulner Lara , Riazalhosseini Yasser , Lathrop Mark , Harris Adrian , Selby Peter J. , Banks Rosamonde E. , Vasudev Naveen S. 
Published: May 2020

Abstract
Background
Indoleamine 2,3-dioxygenase (IDO), the first step in the kynurenine pathway (KP), is upregulated in some cancers and represents an attractive therapeutic target given its role in tumour immune evasion. However, the recent failure of an IDO inhibitor in a late phase trial raises questions about this strategy.

Methods
Matched renal cell carcinoma (RCC) and normal kidney tissues were subject to proteomic profiling. Tissue immunohistochemistry and gene expression data were used to validate findings. Phenotypic effects of loss/gain of expression were examined in vitro.

Results
Quinolate phosphoribosyltransferase (QPRT), the final and rate-limiting enzyme in the KP, was identified as being downregulated in RCC. Loss of QPRT expression led to increased potential for anchorage-independent growth. Gene expression, mass spectrometry (clear cell and chromophobe RCC) and tissue immunohistochemistry (clear cell, papillary and chromophobe), confirmed loss or decreased expression of QPRT and showed downregulation of other KP enzymes, including kynurenine 3-monoxygenase (KMO) and 3-hydroxyanthranilate-3,4-dioxygenase (HAAO), with a concomitant maintenance or upregulation of nicotinamide phosphoribosyltransferase (NAMPT), the key enzyme in the NAD+ salvage pathway.

Conclusions
Widespread dysregulation of the KP is common in RCC and is likely to contribute to tumour immune evasion, carrying implications for effective therapeutic targeting of this critical pathway