bluuebunny/crossref_metadata_2025_split huggingface dataset:
BowtieArene: A Dual Macrocycle Exhibiting Stimuli‐Responsive Fluorescence
Authors: Lei Sheng‐Nan , Xiao Hongyan , Zeng Yi , Tung Chen‐Ho , Wu Li‐Zhu , Cong Huan 
Published: December 2019

AbstractAlthough highly useful in supramolecular chemistry, pillararenes lack a fluorophore in their skeleton. Here we present BowtieArene, a novel fluorescent dual macrocycle, featuring a central tetraphenylethylene‐derived fluorophore and two pillar‐like, pentagon‐shaped cavities which are comparable to pillar[5]arene. This concisely prepared, figure‐of‐eight molecule exhibits vapor absorption and host–guest capabilities, as well as intriguing switchable fluorescence. The fluorochromism of BowtieArene can be triggered by multiple external stimuli including solvent, vapor, and mechanical force, with excellent reversibility and stability. Experimental and theoretical evidence indicate that the fluorochromism should be closely related to molecular packing.
Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells
Authors: Zajac Juraj , Novohradsky Vojtech , Markova Lenka , Brabec Viktor , Kasparkova Jana 
Published: December 2019

AbstractTo design an anticancer drug capable of inhibiting not only the proliferation of the differentiated tumor cells but also reducing the tumorigenic capability of cancer stem cells (CSCs), the new PtIV prodrugs with axial cinnamate ligands were synthesized. We demonstrate their superior antiproliferative activity in monolayer and 3D spheroid antiproliferative activity tests using panel of cancer cell lines. An outstanding activity was found against rhabdomyosarcoma cells, one of the most problematic and poorly treatable pediatric tumors. The results also suggest that the released PtII compound inhibits antiproliferative activity of cancer cells by DNA‐damage mediated mechanism; the released cinnamic acid can trigger processes leading to differentiation, making the CSCs more sensitive to killing by the platinum part of the complex. PtIV complex with axial cinnamate ligands is the first PtIV prodrug capable of overcoming CSCs resistance and induce death in both CSCs and bulk cancer.
Mechanical milling of thermoresponsive poly(N‐isopropylacrylamide) hydrogel for particle‐oriented oil–water separation
Authors: Otanicar Todd , Patel Jay , Sarica Erhan 
Published: December 2019

ABSTRACTThe separation of oil and water is widely studied because of the promise of cleaning up oil spills. One pathway is with thermosensitive polymer‐based hydrogels. As hydrogels are raised to the lower critical solution temperature (LCST), they undergo a change of state, from hydrophilic to hydrophobic. Oil–water separation using hydrogels in particle form that are responsive to external stimuli (e.g., magnetic field and temperature) are of great interest. This work uses a novel approach of ball milling dry hydrogel into different sizes and testing oil–water separation efficacy. This study investigated the potential for ball milling P(NIPAAm) bulk hydrogel into small particles size ranges (0–45, 45–90, 90–106, 106–150, and 150+ μm) and the resulting impact on oil–water separation. It was observed that the LCST for the p(NIPAAm) in gel form was 32 °C while increasing to ~40 °C for the powdered form. It was found that the hydrogel particles of different size ranges managed to capture 196, 207, 208, 162, and 124% of its weight in oil, respectively. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48771.
Boom Chack Boom—A multimethod investigation of motor inhibition in professional drummers
Authors: Schlaffke Lara , Friedrich Sarah , Tegenthoff Martin , Güntürkün Onur , Genç Erhan , Ocklenburg Sebastian 
Published: December 2019

AbstractIntroductionOur hands are the primary means for motor interaction with the environment, and their neural organization is fundamentally asymmetric: While most individuals can perform easy motor tasks with two hands equally well, only very few individuals can perform complex fine motor tasks with both hands at a similar level of performance. The reason why this phenomenon is so rare is not well understood. Professional drummers represent a unique population to study it, as they have remarkable abilities to perform complex motor tasks with their two limbs independently.MethodsHere, we used a multimethod neuroimaging approach to investigate the structural, functional, and biochemical correlates of fine motor behavior in professional drummers (n = 20) and nonmusical controls (n = 24).ResultsOur results show that drummers have higher microstructural diffusion properties in the corpus callosum than controls. This parameter also predicts drumming performance and GABA levels in the motor cortex. Moreover, drummers show less activation in the motor cortex when performing a finger‐tapping task than controls.ConclusionIn conclusion, professional drumming is associated with a more efficient neuronal design of cortical motor areas as well as a stronger link between commissural structure and biochemical parameters associated with motor inhibition.
Antibacterial Diphenyl Ether, Benzophenone and Xanthone Derivatives from Aspergillus flavipes
Authors: Ji Yu‐Bin , Chen Wen‐Ju , Shan Ti‐Zhuang , Sun Bi‐Yun , Yan Peng‐Cheng , Jiang Wei 
Published: December 2019

AbstractThe extract of the strain Aspergillus flavipes DL‐11 exerted antibacterial activities against six Gram‐positive bacteria. During the following bioassay‐guided separation, ten diphenyl ethers (1–10), two benzophenones (11–12), together with two xanthones (13–14) were isolated. Among them, 4′‐chloroasterric acid (1) was a new chlorinated diphenyl ether. Their structures were elucidated by extensive spectroscopic data analysis, including IR, HR‐ESI‐MS, NMR experiments, and by comparison with the literature data. All compounds showed moderate to strong antibacterial effects on different Gram‐positive bacteria with MIC values that ranged from 3.13 to 50 μg/mL, but none of the compounds exhibited activity against Gram‐negative bacteria Vibrio parahaemolyticus ATCC17802 (MIC>100 μg/mL). In particular, the MICs of some compounds are at the level of positive control.
An Imatinib–non‐responsive patient with an ABL Leu387Trp mutation achieves cytogenetic and molecular response under bosutinib: Case report and biological characterization
Authors: Crespiatico Ilaria , Bossi Elisa , Brioschi Filippo , Piazza Rocco , Mologni Luca , Gambacorti‐Passerini Carlo 
Published: December 2019

AbstractLeu387Trp mutation, aroused in an imatinib‐non‐responsive CML patient, was selected by imatinib treatment along with other unknown factors responsible for resistance, and then it was overcome by bosutinib. These results will be useful for treating patients with this rare mutation and will advise against automatically considering a new mutation as the cause of TKI resistance.
Lymphoepithelial pancreatic cyst: A rare entity among pancreatic cystic lesions. Report of two cases
Authors: Davakis Spyridon , Syllaios Athanasios , Kyros Eleandros , Dimitrokallis Nikolaos , Orfanos Stamatios , Vailas Michail , Papalampros Alexandros , Felekouras Evangelos 
Published: December 2019

AbstractLymphoepithelial pancreatic cysts are extremely rare benign pancreatic cystic lesions. High suspicion and an individual approach are imperative for the best management of those extremely rare entities.
Autonomic and peripheral neuropathy with reduced intraepidermal nerve fiber density can be observed in patients with gastrointestinal dysmotility
Authors: Ohlsson Bodil , Dahlin Lars B. , Englund Elisabet , Veress Béla 
Published: December 2019

AbstractNeuropathy should be considered as a possible etiological factor in patients with severe gastrointestinal symptoms, without signs of disease on routine investigations. Examinations of the autonomic and peripheral nervous systems may be helpful to select the patients who should be investigated with full‐thickness intestinal biopsy, and to give appropriate care.
Mechanochemical Palladium‐Catalyzed Carbonylative Reactions Using Mo(CO)6
Authors: van Bonn Pit , Bolm Carsten , Hernández José G. 
Published: December 2019

AbstractEsters and amides were mechanochemically prepared by palladium‐catalyzed carbonylative reactions of aryl iodides by using molybdenum hexacarbonyl as a convenient solid carbonyl source and avoiding a direct handling of gaseous carbon monoxide. Real‐time monitoring of the mechanochemical reaction by in situ pressure sensing revealed that CO is rapidly transferred from Mo(CO)6to the active catalytic system without significant release of molecular carbon monoxide.
Second‐Coordination Sphere Effects on Selectivity and Specificity of Heme and Nonheme Iron Enzymes
Authors: de Visser Sam P. 
Published: December 2019

AbstractMononuclear iron‐containing enzymes are highly versatile oxidants that often react stereospecifically and/or regioselectively with substrates. Combined experimental and computational studies on heme monooxygenases, nonheme iron dioxygenases and halogenases have revealed the intricate details of the second‐coordination sphere, which determine this specificity and selectivity. These second‐coordination sphere effects originate from the positioning of the substrate and oxidant, which involve the binding of the co‐factors and substrate into the active site of the protein. In addition, some enzymes affect the selectivity and reactivity through charge‐stabilization from nearby bound cations/anions, an induced electric field or through the positioning of salt bridges and hydrogen‐bonding interactions to first‐coordination sphere iron ligands and/or the substrate. Examples of all of these second‐coordination sphere effects in iron‐containing enzymes and how these influence structure and reactivity are given.
Cucurbit[7]uril‐Based Metal–Organic Rotaxane Framework for Dual‐Capture of Molecular Iodine and Cationic Potassium Ion
Authors: Zhang Xiu‐Du , Zhao Yue , Chen Kai , Dao Xiao‐Yao , Kang Yan‐Shang , Liu Yi , Sun Wei‐Yin 
Published: December 2019

AbstractMetal–organic rotaxane frameworks (MORFs) attracted much attention in the past years for construction of intelligent functional materials. Herein, a one‐pot synthesis is reported of a three‐dimensional (3D) cucurbit[7]uril (Q[7])‐based MORF under hydrothermal conditions, namely Q[7]‐MORF‐1, formed by encapsulating the anionic benzoate moieties of the tricarboxylate ligand into the cavity of Q[7]. Furthermore, Q[7]‐MORF‐1 shows dual‐capture capacity for iodine and K+ selectively among the alkali metal ions. The captured molecular iodine is included in the cavity of Q[7] through halogen‐bonding interactions and the K+ cations are positioned at the carbonyl port of the Q[7] through K−O coordination interactions.
The Effect of Oligo(Ethylene Oxide) Side Chains: A Strategy to Improve Contrast and Switching Speed in Electrochromic Polymers
Authors: Chen Youquan , Yin Yuyang , Xing Xing , Fang Daqi , Zhao Yang , Zhu Yanan , Ali Muhammad Umair , Shi Yuhao , Bai Junwu , Wu Peiheng , Shen Clifton Kwang‐Fu , Meng Hong 
Published: December 2019

AbstractSolution‐processable electrochromic polymers (ECPs) with high performance are urgently needed for extensive applications. Nevertheless, they suffer from slow switching speed because of low ionic conductivities. Herein, we present an effective strategy to improve the contrast and switching speed in ECPs via facile side‐chain engineering. A novel electrochromic thieno[3,2‐b]thiophene‐based polymer (PmOTTBTD) is designed and successfully synthesized by introducing oligo(ethylene oxide) side chains with high ionic conductivity. Compared to the counterpart POTTBTD without modification by oligo(ethylene oxide) chains, PmOTTBTD demonstrates nearly double contrast (42 % vs. 24 %) with a fast oxidation switching process that just takes half of the time when detected under 400 nm, as well as much higher coloration efficiencies (e. g. 239.04 cm2 C−1 vs. 226.26 cm2 C−1 @ 400 nm and 314.04 cm2 C−1 vs. 174.00 cm2 C−1 @ 650∼700 nm). Besides, PmOTTBTD exhibits excellent stability with negligible decay after 3000 cycles. Our work suggests a facile strategy that could be adopted to realize high‐performance ECPs via molecular design tuning.
Outage analysis of opportunistic‐based hybrid decode‐amplify‐forward relaying in polar code environment
Authors: Madhusudhanan Natarajan , Venkateswari Rajamanickam 
Published: December 2019

SummaryOutage analysis plays a vital role in wireless systems to determine reliable transmission and effective communication. Incremental hybrid decode‐amplify‐forward (IHDAF) relay offers a way of meeting the challenges of capacity and coverage improvement with great potential in cooperative communication networks. Therefore, opportunistic incremental hybrid relaying must be integrated with coding schemes to achieve full diversity. In this paper, the outage behavior of polar coded and distributed coded cooperative relaying schemes is analyzed. Simulation results show that opportunistic incremental HDAF using polar code offers an outage capacity of 17 b/s/Hz for 4 × 4 multiantenna and 45 b/s/Hz in 8 × 8 multiantenna systems with an outage of 10−8 and 10−13, respectively. Moreover, the polar coded opportunistic IHDAF system in 8 × 8 MIMO achieves 2 and 6 dB higher gains compared with amplify‐and‐forward (AF) and decode‐and‐forward (DF) relaying schemes. The closed‐form expression for outage probability has been derived through Marcum‐Q approximations and processed through Monte Carlo simulations.
An Impedance Molecularly Imprinted Sensor for the Detection of Bovine Serum Albumin (BSA) Using the Dynamic Electrochemical Impedance Spectroscopy
Authors: Ma Ya , Liu Cheng , Zeng Qiang , Wang Li‐Shi 
Published: December 2019

AbstractA molecularly imprinted electrochemical sensor is successfully developed to detect bovine serum albumin (BSA) based on the dynamic electrochemical impedance spectroscopy (DEIS) instead of the traditional impedance spectroscopy. The sensor is prepared using chitosan and pyrrole as modified material and functional monomers, respectively, and the fast and real‐time characterization of molecular imprinting process can be obtained by DEIS. It is indicated that the removal and rebinding processes of BSA are closely related with the DEIS impedance under dynamic conditions, and the direct correlation between the resulting kinetic information and BSA concentrations can be established. As a result, the impedance changing rates in the initial 5 min of BSA adsorption are linear to the BSA concentrations ranging from 0.0001 to 0.01 ng mL−1 and 0.01 to 1 ng mL−1 with a detection limit of 5×10−5 ng mL−1 (S/N=3). In addition, the detection of BSA by DEIS does not require the system to be in equilibrium. The sensor also shows simplicity, high sensitivity, good stability and acceptable recovery in real samples, indicating its promising prospects in the fast and real‐time detection of proteins.
Feasibility, acceptability, and effectiveness of a multidisciplinary intervention in childhood obesity from primary care: Nutrition, physical activity, emotional regulation, and family
Authors: Sepúlveda Ana R. , Solano Santos , Blanco Miriam , Lacruz Tatiana , Veiga Oscar 
Published: December 2019

AbstractChildhood obesity is a growing problem with a complex aetiology, for which multidisciplinary interventions are required. Our programme describes a novel structured psychosocial family‐based intervention targeting the emotional regulation in childhood obesity, using a train trip metaphor aimed at improving healthy lifestyles for the family. The aims were (a) to describe the feasibility and acceptability of this psychosocial family‐based intervention among children with overweight or obesity in primary care and (b) to examine the effectiveness of the “ENTREN‐F” programme (with family intervention) compared with the “ENTREN” programme (without family intervention) among Spanish children regarding anthropometric variables, physical activity, emotional well‐being, and family functioning. Children were randomly allocated to either ENTREN‐F programme (n = 30) or psychological intervention for children (ENTREN, n = 40), and assessments were carried out over time (T0 baseline vs. T1 post/6‐month vs. T2 6‐month follow‐up). Both parent groups expressed high levels of satisfaction with the interventions. ENTREN‐F resulted in higher adherence to treatment and was more effective in improving z–body mass index, reducing children's anxiety, and increasing family adaptability than the ENTREN programme. There were no significant changes in parents' emotional well‐being and expressed emotion. Both groups improved in the children's emotional well‐being and light physical activity. In summary, this multidisciplinary psychosocial family‐based intervention was succesful.
Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts
Authors: Wei Qi , Zhan Yishu , Chen Bingzhi , Xie Baogui , Fang Ting , Ravishankar Sadhana , Jiang Yuji 
Published: December 2019

AbstractAgaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract). The antioxidant activities of ABM ethanol extract (EE) and ethyl acetate extract (EA) were analyzed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), and hydroxyl radical scavenging assays and the reducing power using K3Fe(CN)6 in vitro. Moreover, the effects of EE and EA on α‐glucosidase inhibitory activity and improving glucose uptake by HepG2 cells were investigated in vitro. The EA showed stronger antioxidant activity, as well as inhibition of α‐glucosidase, compared to EE. The analysis of glucose uptake by HepG2 cells showed that EA had significant glucose‐lowering activity and exhibited no difference compared to metformin. The results suggest that ABM extracts could improve the glucose uptake by HepG2 cells and thereby alleviate postprandial hyperglycemia. This investigation provides a strong rationale for further studies on the application of ABM to control type 2 diabetes.
Multiproxy evidence for rapid and enduring anthropogenic vegetation change during the Late Holocene from an abandoned channel of the Mississippi River, Wapanocca Bayou, Arkansas, USA
Authors: Aiuvalasit Michael , Riley Tim , Schuldenrein Joseph 
Published: December 2019

AbstractGeoarchaeological cores from an infilling channel within the meander belt of the Central Mississippi Valley recovered multiproxy evidence of vegetation changes during the Late Holocene. The sampling site, Wapanocca Bayou (Crittenden County, Arkansas), is flanked by levees that supported settlements of prehistoric Late Woodland and Mississippian farm sites, villages, and towns (AD 300–1650). These settlements include the Bradley site (3CT7), which was potentially the capital of a powerful Native American chiefdom visited by Hernando De Soto's North American expedition in 1541. Age‐depth modeling of radiocarbon dates from a 10+ meter core indicates continuous infilling of the channel since at least 2,450 cal BP. Palynological records preserve diachronic and patterned shifts in vegetation reflecting significant disturbances in these dynamic meander‐belt settings. Coeval trends in soil phosphorus, organic matter, charcoal concentrations, and magnetic susceptibility combined with archaeological evidence for increasingly intense landuse practices support our argument that vegetation changes along Wapanocca Bayou were caused by prehistoric anthropogenic disturbances, rather than natural processes associated with oxbow infilling and terrestrialization. With time the role of the natural vegetation succession receded in relative importance as local ecosystems were progressively modified by prehistoric Native Americans. This change was then sustained by intensified historical agricultural practices.
Do stock price bubbles correlate between China and Pakistan? An inquiry of pre‐ and post‐Chinese investment in Pakistani capital market under China‐Pakistan Economic Corridor regime
Authors: Liaqat Ayesha , Nazir Mian Sajid , Ahmad Iftikhar , Mirza Hammad Hassan , Anwar Farooq 
Published: December 2019

AbstractThis paper examines the existence and coincidence of pre‐ and‐post stock price multiple bubbles in Chines and Pakistani capital markets under China Pakistan Economic Corridor regime using generalized supremum augmented Dickey–Fuller (GSADF) test with weekly closing prices for the period 2013–2018 for different market indices of Pakistan Stock Exchange (PSX), Shanghai Stock Exchange, and Shenzhen Stock Exchange. Empirical results depict that multiple stock bubbles exist in PSX at the end of 2016 and as well as in Chinese stock markets in the mid of 2014–2015 and these stock price bubbles are correlated between Pakistan and China. The present study is expected to be pioneer in its nature to apply GSADF for the identification of multiple stock bubbles in emerging stock markets of Pakistan and China which can be further used for comparison of stock bubbles in other regional markets such as BRICS or SAARC regions.
Lipidomic profiling of amniotic fluid and its application in fetal lung maturity prediction
Authors: Cao Zheng , Liu Jingrui , Xie Xin , Zhan Sien , Song Wei , Wu Shaowen , Sun Zheng , Dong Ying , Tang Guodong , Liu Yilin , Li Lin , Shen Min , Zhai Yanhong , Zou Jihua , Liu Xiaowei 
Published: December 2019

BackgroundThe pulmonary surfactant especially lipids in amniotic fluid can reflect the development stage of fetal lung maturity (FLM). However, the conventional lecithin/sphingomyelin (L/S) ratio method by thin layer chromatography (TLC) is insufficient and inconvenient for FLM prediction in clinical practice.MethodsThe amniotic fluid samples were collected from the pregnant women in labor or undergoing amniocentesis and analyzed for its lipid contents with the liquid chromatography coupled with high‐resolution mass spectrometry (LC‐HRMS) method and the lamellar body count (LBC) method. To reveal the lipidomic profiling of different FLM stages, three groups of amniotic fluid samples including 8 from premature group (gestational week (GW) < 37), 10 from mature group (GW < 37), and 10 from mature group (GW > 38) were compared with the control group (n = 6) of 18 GWs separately.ResultsIn the FLM prediction study, the sensitivity of the LC‐HRMS method and LBC method was 91% and 73%, respectively; the specificity was 100% and 95%, respectively. The most significant metabolic pathway was linoleic acid metabolism between the premature group and the control group. Both glycerophospholipid metabolism and glycosylphosphatidylinositol‐anchor biosynthesis were enriched in the mature groups. In search of potential FLM prediction markers in amniotic fluid, 8 phosphatidylcholines, 1 sphingomyelin, and 1 phosphatidylethanolamine were significantly increased in the mature groups compared with the premature group.ConclusionAn efficient LC‐HRMS method for L/S ratio in predicting FLM was established. The linoleic acid metabolism may play an important role in the fetal lung development.