bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a MPR‐based 3DTEE guidance protocol for transcatheter direct mitral valve annuloplasty
Authors: Geyer Martin , Sotiriou Efthymios , Keller Karsten , Tamm Alexander R. , Ruf Tobias F. , Kreidel Felix , Beiras‐Fernandez Andres , Kornberger Angela , Yang Yang , Emrich Tilman , Schulz Eberhard , Münzel Thomas , von Bardeleben Ralph Stephan 
Published: August 2020

AbstractObjectivesSeveral interventional approaches have been established for the treatment of severe mitral regurgitation (MR) in patients at elevated risk for surgery. Direct annuloplasty is a relatively novel option in transcatheter mitral valve repair dedicated to reverse pathology in specific subsets of MR. With regard to echocardiographic guidance, this procedure presents with higher efforts in comparison with edge‐to‐edge therapy to enable safe and exact positioning of the device's anchors; evidence on optimal peri‐interventional imaging is sparse. We tested a specific 3D‐echo‐guidance protocol implementing single‐beat multiplanar reconstruction (MPR) and evaluated its feasibility.MethodsOverall, 16 patients consecutively treated with transcatheter direct annuloplasty for severe MR (87.5% functional/6.3% degenerative/6.3% mixed pathology) were entered in this monocentric analysis. Of these, two patients received a combined procedure including edge‐to‐edge repair. For all implantations, a 3D‐echo‐guidance protocol inheriting MPR was employed.ResultsPeriprocedural device time decreased continuously (overall mean 140 ± 55.1 minutes, 213 ± 38 minutes in the first 4 vs 108 ± 33 minutes in the last 4 procedures, P = .018) using the MPR‐based echo protocol, going along with reduced fluoroscopy times and doses. Technical success rate was high (93.8%) without any serious cardiac‐related adverse events. MR could be relevantly improved.ConclusionEchocardiographic guidance of transcatheter direct annuloplasty using a real time MPR‐based protocol is feasible and safe. Optimized imaging might enable reduced implantation times and potentially increases safety.
Outcome of degenerative nonprolapse mitral regurgitation using the average pixel intensity method
Authors: Kamoen Victor , El Haddad Milad , De Backer Tine , De Buyzere Marc , Timmermans Frank 
Published: August 2020

AbstractBackgroundPrimary mitral valve regurgitation (MR) is a comprehensive term that mostly comprises mitral valve prolapse (MVP), while other causes of degenerative MR are often not considered. We describe the echocardiographic characteristics of degenerative nonprolapse mitral regurgitation (DMR) and assess the outcome at medium‐term follow‐up using the novel average pixel intensity (API) method.MethodsOf 126 patients with any nonprolapse DMR were consecutively included. MR was graded according to all guideline‐recommended parameters and with the API method. MR flow dynamics in DMR were compared to MVP‐MR and functional MR (FMR).ResultsDMR is associated with moderate‐to‐severe calcifications of the mitral valve apparatus, and a low event rate was observed at a mean follow‐up of 27 months. The API grading method had a higher feasibility (94%) compared to proximal isovelocity surface area (PISA) (60%) method and vena contracta width (VCW) (71%) for assessing MR. The API method was predictive for events.The API method also provides insights into DMR flow dynamics: A triphasic pattern was observed with a midsystolic nadir for both API and PISA‐EROA, which is similar to the dynamic flow pattern described in FMR, but distinct from holosystolic MVP‐MR. Compared to FMR and MVP‐MR patients, DMR is less severe and patients with DMR are generally older than MVP‐MR patients.ConclusionsDMR is a distinct MR pathology and conveys a relatively low event rate. MR grading was feasible with the API method, and flow dynamics demonstrated a similar triphasic pattern compared to FMR but distinct from holosystolic MVP‐MR.
Echocardiographic assessment of simultaneously measured left ventricular filling pressures in patients with normal left ventricular ejection fraction
Authors: Sun Jing Ping , Liang Yi , Zhang Fen , Chen Xinxin , Yuan Wei , Xu Liangjie , Bahler Robert C. , Yan Jinchuan 
Published: August 2020

AbstractBackgroundAssessment of left ventricular (LV) diastolic function is part of routine echocardiographic examinations. Accuracy of the 2016 ASE/EACVI algorithm to detect LV diastolic dysfunction in patients with a normal LV ejection fraction (LVEF) has been examined but simultaneous measurements of LV pressures and echocardiographic parameters of diastolic function are sparse.MethodsThe accuracy of multiple echo parameters of diastolic dynamics and the 2016 guidelines were assessed by simultaneous transthoracic echocardiography and LV pressure recordings in 120 patients (derivation cohort) and 60 patients (validation cohort) with suspected coronary artery disease and normal LVEF. Receiver‐operating characteristic (ROC) curves defined optimal cut points for each echocardiographic parameter. A new algorithm was proposed to estimate LV diastolic pressures using 5 parameters based on ROC data: tricuspid regurgitation velocity >280cm/s, average e' <9 cm/s, average E/e' ratio >13, velocity of pulmonary vein A‐wave reversal >32 cm/s, and left atrial volume index >32 mL/m2. Performances of the 2016 guidelines and a proposed algorithm were examined for detecting a LV pre‐A >12 and LV end‐diastolic pressure (LVEDP) >15 mm Hg.ResultsIn the derivation cohort, the 2016 algorithm identified an elevated LVEDP >15 mm Hg with an accuracy of 74.2% (63.8–82.9); the modified algorithm improved accuracy to 86.0% (77.6–92.1), P < .05. In the validation cohort, the proposed algorithm improved sensitivities with accuracies remaining like the 2016 algorithm.ConclusionsLV diastolic pressures in patients with normal LVEF were reliably assessed by the 2016 guidelines. The proposed algorithm improved sensitivities and may improve the accuracies for detecting abnormal LV filling pressures.
Prenatal diagnosis of left‐sided aortic arch, right descending aorta and right‐sided ductus arteriosus associated with anomalous origin of left pulmonary artery from ascending aorta
Authors: Han Jiancheng , Wang Jingyi , Gao Shuang , Li Tianjing , Hao Xiuxiu , He Yihua 
Published: August 2020

AbstractLeft‐sided aortic arch (LAA), right descending aorta (rDAo), and right‐sided ductus arteriosus (RDA) constitute a rare aortic arch anomaly. Moreover, anomalous origin of the pulmonary artery from the ascending aorta, especially that of the left pulmonary artery, is also a rare anomaly of the pulmonary artery branches. Because of the presence of the ductus arteriosus, prenatal ultrasound is an optimal diagnostic tool for the LAA with rDAo. Four‐dimensional color Doppler can clearly demonstrate the spatial relationship between the LAA, rDAo, and RDA and the anomalous origin of the left pulmonary artery from the ascending aorta.
Developing a clinical presentation dental education model and a pilot test
Authors: Ji Young‐A , Kho Hong‐Seop , Kwon Ho‐Beom , Kim Young‐Jae , Seol Yang‐Jo , Huh Kyung‐Hoe , Kim Ryan Jin‐Young , Yoon Hyung‐In , Baek Seung‐Ho 
Published: August 2020

AbstractIntroductionAccurate clinical decision‐making of dentists should be based on their knowledge and experience. In the past 10 years, interest in competency‐based dentistry education has rapidly increased, but there has been little attention paid to methods of improving dental education competency. The purpose of this study was to develop a clinical presentation education model that provides opportunities for students to practice problem‐solving from the moment they greet the patient so that students can obtain the practical experience of competency‐based education and the effectiveness of this model can be confirmed through pilot test.MethodsThis article is divided two parts: First, developing the clinical presentation dental education model (CPDEM) and Second, a pilot study adopted CPDEM. To confirm the effectiveness of this model, the students' satisfaction, their perception of self‐achievement were analysed.ResultsClinical presentation dental education model has been developed to provide practice‐related education experience and provide linkage between basic science and clinical science. The result of applying this education model to 10 students as a pilot test was shown an overall high satisfaction level. In addition, self‐achievement students’ reported of all intended competencies was higher than for non‐participating students of this model.ConclusionsThis study focuses on practical education centring on clinical presentation. This model could get a meaningful and realistic experiences through the practice using clinical presentation of patients, use their metacognition for organizing and memorizing the patient's case by using concept map. It can be used as a future instructional method to enhance students' competency.
Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson’s disease: review and meta‐analysis
Authors: Jiménez‐Jiménez F. J. , Alonso‐Navarro H. , García‐Martín E. , Agúndez J. A. G. 
Published: August 2020

Background and purposeThe present systematic review and meta‐analysis aims to establish the possible value of cerebrospinal fluid (CSF) and serum/plasma levels of amino acids as markers of Parkinson’s disease (PD).MethodsThis is a review of four databases (PubMed, Embase, MEDLINE and Web of Science – Core Collection) from 1966 to 14 March 2020, with identification of references of interest for the topic. The meta‐analysis of eligible studies was done using R software package meta, following the PRISMA and MOOSE guidelines.ResultsCompared with age‐ and sex‐matched controls, PD patients showed decreased CSF levels of glutamate and taurine and increased CSF levels of tyrosine; decreased serum/plasma levels of aspartate, serine, tryptophan and lysine, and increased serum/plasma proline and homocysteine levels.ConclusionDespite the limitations of this study due to the important variability of results between different series, our findings suggest the value of CSF or serum/plasma levels of several amino acids in the discrimination of PD patients from healthy subjects, related to the levels of some amino acids.
Orthodoxy and Science
Authors: Costache Doru 
Published: August 2020

AbstractThe Orthodox Church is uneasy about contemporary science. What causes its uneasiness is not exclusively its slow reception of modern culture. An important cause is the fact that contemporary research sidelines ethical and spiritual criteria. The practical application of scientific discoveries in the area of biotechnologies provides abundant evidence for this. That said, progress is being made in regard to the Orthodox appraisal of modern culture and contemporary science and toward self‐assessment against current cultural trends. This progress cannot make an impact, however, without an authenticating framework. Fortunately, three documents of the Holy and Great Council of the Orthodox Church provide an implicit framework for addressing matters such as the Orthodox attitude toward science, especially biology and its related branches, in light of theological anthropology and traditional ethical and spiritual criteria. A shared particularity of these documents is that they consider modern culture and scientific research in a missional perspective.
The Perspectives and Challenges of Primacy and Synodality in the Orthodox Church Today
Authors: Job (Getcha) of Telmessos Archbishop 
Published: August 2020

AbstractThe Holy and Great Council of the Orthodox Church in 2016 should be perceived and received as a genuine manifestation of synodality at the beginning of the 21st century. It has reminded us that it is within the exercise of primacy and synodality at the universal level that the unity and the orthodoxy of the church is guaranteed. Its message referred to the proposal for the Holy and Great Council to become a regular institution to be convened every seven or ten years. By saying this, the Holy and Great Council has perhaps inaugurated a new era of synodality in the Orthodox Church on the universal level. This is perhaps the greatest contribution of the Holy and Great Council in an era of globalization, when the pastoral problems encountered by each local autocephalous church, due to a growing secularization of the world, are very similar and need a common synodal response.
The Revival of Orthodox Mission in New Borders and the Holy and Great Council of the Orthodox Church
Authors: Archbishop Anastasios of Tirana, Durrës, and All Albania  
Published: August 2020

AbstractOne of the critical issues emphasized at the Holy and Great Council of the Orthodox Church in Crete in 2016 was that of the witness of Orthodoxy in the modern world, as expressed in the Message and Encyclical of the council, and in the council document on the Mission of the Orthodox Church. This paper traces the revival of foreign mission and witness within the Orthodox Church since the late 1950s and how it came to fruition at the council in Crete.
Orthodoxy in Unity and in Conciliarity
Authors: Metropolitan Gennadios of Sassima  
Published: August 2020

AbstractThis article considers how the Holy and Great Council of the Orthodox Church faced challenges such as how the gospel relates to a pluralistic society; the Christian message in a society marked by religious pluralism, ethnic diversity, and cultural relativism; whether Christians encountering today's pluralist society should concentrate on evangelism or on dialogue; and on how conciliarity relates to the unity of the church. The article examines how the council attempted to respond to, or at least reflect on, these challenges in relation to the theological dialogue of the Orthodox Church with the other Christian churches and confessions. The bilateral theological dialogues have also increasingly led to bearing Christian witness, and an atmosphere of mutual appreciation, friendship, and fellowship has already become at least a reality. But has this development also led to a deeper mutual theological understanding? Have the profound differences between the Orthodox churches and the other churches in bilateral dialogues been clarified theologically?
The Documents of the Holy and Great Council on Marriage and Fasting
Authors: Meyendorff Paul 
Published: August 2020

AbstractThis article offers a critical response to the documents on marriage and on fasting of the Holy and Great Council of the Orthodox Church, which took place in Crete in 2016. It suggests greater attention be given to the concept of oikonomia in contemporary Orthodoxy, both in the context of the issues raised in these two documents and with respect to other contentious issues. In contemporary Orthodoxy, the exercise of oikonomia is understood in different ways. One approach is the legalistic understanding of the term that is employed in the council documents; the second and more traditional approach is to understand oikonomia as discernment of what is true and authentic, even outside the canonical limits of Orthodoxy. The article asks whether such a perspective could characterize the church’s approach to other complex pastoral issues, such as those related to marriage and fasting.
Discerning the Ministries of Women
Authors: FitzGerald Kyriaki Karidoyanes 
Published: August 2020

AbstractIn 1988, the historic Rhodes Inter‐Orthodox Symposium on the Place of Women in the Orthodox Church encouraged, among other things, fuller participation of women in the life of the church. This article reports on the results of a study that solicited the views of Orthodox Christians regarding the participation of women in the life of the church. Nearly three‐quarters of respondents clearly stated or intimated that they would like to see more opportunities for women to serve in the church. One‐third of the respondents identified the issue of deaconesses in their essays. Responses here revealed a great diversity of experience, education, and opinion. Nevertheless, more than half of the respondents commenting on deaconesses showed an openness to this ministry. This may be a powerful measurement indicating that exploring the pastoral need for this and other ministries may well be long overdue.
Effect of crack path and high angle grain boundaries on fracture toughness and fatigue behaviour of cryorolled AA2219
Authors: B. Blessto , Katakam Sivaprasad , Veerappan Muthupandi , M. Arumugam 
Published: August 2020

AbstractAA2219 aerospace alloys in T87 condition were rolled at room temperature and subzero temperature, followed by analysis on its tensile, fracture toughness and fatigue crack growth characteristics. The cryorolled alloy exhibits lower plane stress fracture toughness (50 kJ m−2) than T87 condition (99 kJ m−2) because of higher high angle grain boundaries (HAGBs) which causes an inability to withstand the cyclic deformation. Nevertheless, the cryorolled alloy has shown higher tensile properties and crack growth resistance due to finer grains and large plastic zone size in the crack tip. The unidirectional rolled samples undergo a distinctive zigzag path than the cross‐directional rolled alloy because of deflection from the orderly oriented second phase particles.
Only habitat specialists become smaller with advancing urbanization
Authors: Magura Tibor , Ferrante Marco , Lövei Gábor L. 
Published: August 2020

AbstractAimUrbanization profoundly changes environments, ecosystems and biodiversity. The urban heat island (UHI) effect represents one of the most consistent human‐induced environmental change in urbanized areas. Recently, it was observed that the UHI causes community‐wide shifts towards species with smaller body sizes in urban communities of ectotherms due to increased metabolic costs. We here assembled a large dataset of published data of geographically distant carabid communities collected along urbanization gradients to examine whether we could confirm this consistent change in body size distribution.LocationRural and urban forests at 11 northern temperate locations, spanning 25 latitudinal degrees.Time period2002–2018.Major taxa studiedSpecies of ground beetles (Coleoptera: Carabidae).MethodsWe evaluated size distribution changes using community‐weighted mean body sizes of ground beetles collected from similarly vegetated rural and urban habitats between 2002 and 2018. We separately examined the UHI effect on the various sub‐assemblages of the carabid community.ResultsWhen analysing the entire dataset, we could not detect any clear trend in the community body size mean, with urban communities showing similar values to those sampled in rural areas. However, the sub‐assemblage of forest habitat specialists consistently displayed a significant shift towards smaller species from rural to urban habitats. The inconsistent trend at the community level was likely due to the influx into urban habitat fragments of non‐specialist species. The UHI effect also had a significant influence but only on the forest specialist sub‐assemblage.Main conclusionsOur results indicated that forest‐specialist species were most affected by the UHI as a powerful urbanization‐related environmental filter, whereas this effect was not evident for the overall community. Urban management practices should aim to minimize the intensity of urbanization‐related environmental filters such as the UHI, to enable habitat specialists to survive in habitat fragments under urbanized conditions.
The Global Urban Tree Inventory: A database of the diverse tree flora that inhabits the world’s cities
Authors: Ossola Alessandro , Hoeppner Malin J. , Burley Hugh M. , Gallagher Rachael V. , Beaumont Linda J. , Leishman Michelle R. 
Published: August 2020

AbstractMotivationThe Global Urban Tree Inventory (GUTI) is a compilation of datasets on tree species found in cities and towns throughout the world. GUTI data can be used to address a diverse range of theoretical and applied investigations related to species’ biogeography and distribution, ecological and physiological tolerance to climatic, biophysical and environmental parameters, as well as plant conservation and invasion.Main types of variables containedGUTI contains current taxonomic data for 4,734 tree species planted in urban areas, their conservation status [International Union for Conservation of Nature’s (IUCN’s) Red List of Threatened Species] and invasion potential (Global Register of Introduced and Invasive Species).Spatial location and grainFour hundred and seventy‐three urban areas in seventy‐three countries across five continents. The urban areas spanned 21 of 29 Koppen–Geiger climatic zones, and all 19 Food and Agriculture Organization of the United Nations global ecofloristic zones.Time period and grainGUTI is based on the most recent collections of urban tree inventories and species lists compiled by local authorities or reported in the scientific literature. Most data have been collected or updated since 2010.Major taxa and level of measurementFour thousand seven hundred and thirty‐four tree species (c. 8% of the global known arboreal flora). One‐tenth of these tree species face conservation risk in the wild, whereas 327 species are known to have invasion potential.Software format.xls file.
Ureteral location is associated with survival outcomes in upper tract urothelial carcinoma: A population‐based analysis
Authors: Veccia Alessandro , Antonelli Alessandro , Martini Alberto , Falagario Ugo , Carrieri Giuseppe , Grob Mayer B , Guruli Georgi , Simeone Claudio , Wiklund Peter , Porpiglia Francesco , Autorino Riccardo 
Published: August 2020

ObjectivesTo evaluate the prognostic value of tumor location in patients with upper tract urothelial carcinoma.MethodsWithin the Surveillance, Epidemiology and End Results Incidence Database, 6619 upper tract urothelial carcinoma cases were identified, including 3719 confined to the renal pelvis and 2971 to the ureter. Predictors of surgical technique (kidney sparing surgery versus radical nephroureterectomy), as well as 2‐ and 5‐year cancer‐specific survival and overall survival were evaluated.ResultsMedian follow‐up time was 29 months (interquartile range 0–126 months) for both groups. Multivariate logistic analysis showed tumor dimension as the only factor associated with radical nephroureterectomy (odds ratio 1.02; P < 0.001). Ureteral 2‐ and 5‐year overall survival were lower (log–rank P = 0.001) compared with renal pelvis. When stratifying tumor location according to dimensions, a ureteral carcinoma >3 cm was associated with the worst 2‐ and 5‐year cancer‐specific mortality (Pepe‐Mori P < 0.001), and overall survival (log–rank P < 0.001). The 2‐ and 5‐year cancer‐specific mortality (Pepe‐Mori P < 0.001) and overall survival were the worst for ureteral ≥T3 tumors (log–rank P < 0.001). The 2‐ and 5‐year cancer‐specific mortality (Pepe–Mori P < 0.001) and overall survival (log–rank P < 0.001) were the worst for ureteral grade III–IV cancers. Ureteral tumor location (subdistribution hazard ratio 1.18, P < 0.001), tumor dimension ≥3 (subdistribution hazard ratio 1.25, P < 0.001), T staging (T2–4 all P < 0.001), grading (grade III subdistribution hazard ratio 2.20, P = 0.001; grade IV subdistribution hazard ratio 2.39, P < 0.001) were found to be associated with higher cancer mortality.ConclusionsUreteral tumor location in upper tract urothelial carcinoma seems to be associated with worse oncological outcomes, especially in the case of advanced disease. Although the type of surgical treatment does not seem to impact survival, surgeons should use caution in adopting a kidney‐sparing surgery for patients with ureteral upper tract urothelial carcinoma.