bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent history of psittacosis in Australia: expanding our understanding of the epidemiology of this important globally distributed zoonotic disease
Authors: Polkinghorne Adam , Weston Kathryn M. , Branley James 
Published: February 2020

AbstractPsittacosis is a human systemic disease caused by infection with Chlamydia psittaci. Shortly after reports emerged of a global pandemic associated with contact with imported parrots, Australian researchers including Macfarlane Burnet and others demonstrated that C. psittaci was widespread in Australian parrots. Australian cases over the last two decades have revealed that environmental exposure and contact with infected horses are also risk factors in an increasingly complicated epidemiological picture for this zoonotic disease.
Lead poisoning associated with illicit opium use
Authors: Wong Joshua , Bourke Elyssia , Roberts Vanessa , Lim Seok M. , Johnson Douglas , Hamblin Peter S. , Karunajeewa Harin , Greene Shaun 
Published: February 2020

AbstractLead poisoning is an uncommon and challenging diagnosis to make. In 2018, The Victorian Department of Health issued a health warning following four cases of lead poisoning associated with illicit opium use in Melbourne, Australia. We present these cases to highlight clinical features and the relevant investigations leading to diagnosis. All cases occurred in recent immigrants to Australia, who had access to non‐traditional sources of opioids. Health care professionals should consider lead poisoning in patients with appropriate symptoms and a history of illicit opium use.
Who is asking about medicinal cannabis in palliative care?
Authors: Panozzo Stacey , Le Brian , Collins Anna , Weil Jennifer , Whyte Jan , Barton Michael , Coperchini Maria , Rametta Meri , Philip Jennifer 
Published: February 2020

AbstractFollowing legislative changes in the availability and prescribing of medicinal cannabis in Australia, we sought to understand prospectively the nature of information seeking and requests for medicinal cannabis in consultations between palliative care clinicians and patients with cancer. The 104 discussions were overwhelmingly initiated by patients and carers (93%) and were for a variety of symptoms, reflecting high levels of patient interest in the use of medicinal cannabis in cancer.
Electrophysiological findings during atrial fibrillation reablation: Extending from pulmonary vein reconnection to sequential bipolar voltage map information
Authors: Huo Yan , Kronborg Mads Brix , Richter Utz , Guo Jianping , Ulbrich Stefan , Zedda Angela M. , Kirstein Bettina , Mayer Julia , Pu Liying , Piorkowski Judith , Wagner Michael , Gaspar Thomas , Piorkowski Christopher 
Published: February 2020

AbstractBackgroundLeft atrial substrate modification targeting low voltage zones (LVZ) is an ablation strategy that—in addition to pulmonary vein (PV) isolation—tries to eliminate arrhythmogenic mechanisms harbored in such tissue. Electrophysiological findings at reablation include (a) PV reconnection, (b) reconnection over previous substrate ablation, and (c) de‐novo LVZ.ObjectiveTo study, prevalence and contribution of these arrhythmogenic electrophysiological entities in patients with atrial fibrillation (AF) recurrences.MethodsConsecutive patients with highly symptomatic AF undergoing index and reablation were included (n = 113). In all patients' PV reconnection, reconnection over previous substrate ablation and spontaneous de‐novo LVZ were quantitatively assessed and integrated into an individual reablation strategy. Follow‐up was based on continuous device monitoring.ResultsAt re‐do procedure, 45 out of 113 (39.8%) patients showed PV reconnection as the only electrophysiological abnormality. Reconduction over previous lines was the only electrophysiological abnormality in 8 out of 113 (7.1%) patients. Spontaneous de‐novo LVZ was the only electrophysiological abnormality in 12 out of 113 (10.6%) patients. Combined findings of PV reconnection, line reconduction, and/or spontaneous de‐novo LVZ were seen in 40 out of 113 (35.4%) patients. No detectable electrophysiological abnormality was observed in 8 out of 113 (7.1%) patients. In univariate analysis, none of the tested electrophysiological characteristics independently predicted the outcome after re‐do.ConclusionsIn patients undergoing reablation, we could show that reconduction over previous substrate ablation as well as the development of new low voltage areas are frequent findings besides classical PV reconnection—without a clear leading cause for recurrences. These findings impact reablation strategies as well as the strategic focus during index procedures.
Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population‐based analysis
Authors: Uljarević Mirko , Cooper Matthew N. , Bebbington Keely , Glasson Emma J. , Maybery Murray T. , Varcin Kandice , Alvares Gail A. , Wray John , Leekam Susan R. , Whitehouse Andrew J.O. 
Published: February 2020

ObjectiveRestricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD.MethodParticipants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM‐IV‐TR criteria on a 4‐point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms.ResultsThe associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non‐significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests.ConclusionsThe pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions.
Phylogeography of the European brook lamprey (Lampetra planeri) and the European river lamprey (Lampetra fluviatilis) species pair based on mitochondrial data
Authors: De Cahsan Binia , Nagel Rebecca , Schedina Ina‐Maria , King James J. , Bianco Pier G. , Tiedemann Ralph , Ketmaier Valerio 
Published: February 2020

AbstractThe European river lamprey Lampetra fluviatilis and the European brook lamprey Lampetra planeri (Block 1784) are classified as a paired species, characterized by notably different life histories but morphological similarities. Previous work has further shown limited genetic differentiation between these two species at the mitochondrial DNA level. Here, we expand on this previous work, which focused on lamprey species from the Iberian Peninsula in the south and mainland Europe in the north, by sequencing three mitochondrial marker regions of Lampetra individuals from five river systems in Ireland and five in southern Italy. Our results corroborate the previously identified pattern of genetic diversity for the species pair. We also show significant genetic differentiation between Irish and mainland European lamprey populations, suggesting another ichthyogeographic district distinct from those previously defined. Finally, our results stress the importance of southern Italian L. planeri populations, which maintain several private alleles and notable genetic diversity.
High‐pressure freezing followed by freeze substitution of a complex and variable density miniorgan: the wool follicle
Authors: VELAMOOR S. , RICHENA M. , MITCHELL A. , LEQUEUX S. , BOSTINA M. , HARLAND D. 
Published: February 2020

SummaryCryofixation by high‐pressure freezing (HPF) followed by freeze substitution (FS) is a preferred method to prepare biological specimens for ultrastructural studies. It has been shown to achieve uniform vitrification and ultrastructure preservation of complex structures in different cell types. One limitation of HPF is the small sample volume of <200 µm thickness and about 2000 µm across. A wool follicle is a rare intact organ in a single sample about 200 µm thick. Within each follicle, specialized cells derived from multiple cell lineages assemble, mature and cornify to make a wool fibre, which contains 95% keratin and associated proteins. In addition to their complex structure, large density changes occur during wool fibre development. Limited water movement and accessibility of fixatives are some issues that negatively affect the preservation of the follicle ultrastructure via conventional chemical processing. Here, we show that HPF‐FS of wool follicles can yield high‐quality tissue preservation for ultrastructural studies using transmission electron microscopy.
A Model of Group Prenatal Care for Patients with Prenatally Diagnosed Fetal Anomalies
Authors: Schwarz Jessica G. , Froh Elizabeth , Farmer Mari‐Carmen , Oser Maren , Howell Lori J. , Moldenhauer Julie S. 
Published: February 2020

AbstractThe model of group prenatal care was initially developed to include peer support and to improve education and health‐promoting behaviors during pregnancy. This model has since been adapted for populations with unique educational needs. Mama Care is an adaptation of the CenteringPregnancy Model of prenatal care. Mama Care is situated within a national and international referral center for families with prenatally diagnosed fetal anomalies. In December 2013, the Center for Fetal Diagnosis and Treatment at Children's Hospital of Philadelphia began offering a model of group prenatal care to women whose pregnancies are affected by a prenatal diagnosis of a fetal anomaly. The model incorporates significant adaptations of CenteringPregnancy in order to accommodate these women, who typically transition their care from community‐based settings to the Center for Fetal Diagnosis and Treatment in the late second or early third trimester. Unique challenges associated with caring for families within a referral center include a condensed visit schedule, complex social needs such as housing and psychosocial support, as well as an increased need for antenatal surveillance and frequent preterm birth. Outcomes of the program are favorable and suggest group prenatal care models can be developed to support the needs of patients with prenatally diagnosed fetal anomalies.
Complex sex and estrous cycle differences in spontaneous transient adenosine
Authors: Borgus Jason R. , Puthongkham Pumidech , Venton B. Jill 
Published: February 2020

AbstractAdenosine is a ubiquitous neuromodulator that plays a role in sleep, vasodilation, and immune response and manipulating the adenosine system could be therapeutic for Parkinson's disease or ischemic stroke. Spontaneous transient adenosine release provides rapid neuromodulation; however, little is known about the effect of sex as a biological variable on adenosine signaling and this is vital information for designing therapeutics. Here, we investigate sex differences in spontaneous, transient adenosine release using fast‐scan cyclic voltammetry to measure adenosine in vivo in the hippocampus CA1, basolateral amygdala, and prefrontal cortex. The frequency and concentration of transient adenosine release were compared by sex and brain region, and in females, the stage of estrous. Females had larger concentration transients in the hippocampus (0.161 ± 0.003 µM) and the amygdala (0.182 ± 0.006 µM) than males (hippocampus: 0.134 ± 0.003, amygdala: 0.115 ± 0.002 µM), but the males had a higher frequency of events. In the prefrontal cortex, the trends were reversed. Males had higher concentrations (0.189 ± 0.003 µM) than females (0.170 ± 0.002 µM), but females had higher frequencies. Examining stages of the estrous cycle, in the hippocampus, adenosine transients are higher concentration during proestrus and diestrus. In the cortex, adenosine transients were higher in concentration during proestrus, but were lower during all other stages. Thus, sex and estrous cycle differences in spontaneous adenosine are complex, and not completely consistent from region to region. Understanding these complex differences in spontaneous adenosine between the sexes and during different stages of estrous is important for designing effective treatments manipulating adenosine as a neuromodulator.
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An experience of slow‐Mohs micrographic surgery for the treatment of Dermatofibrosarcoma protuberans: A long‐term cohort study
Authors: Asilian Ali , Honarjou Navid , Faghihi Gita , Saber Mina , Mozafarpoor Samaneh , Hafezi Hossein 
Published: February 2020

AbstractBackgroundDermatofibrosarcoma protuberans (DFSP) is a rare dermal mesenchymal tumor known as a low‐grade, slow‐growing malignancy. The local invasion and high rate of recurrence following surgical treatment are the main concerns to plan the best surgical approach of treatment.AimsIn the current study, it is aimed to provide an experience of slow‐Mohs surgery for the treatment of patients with DSFP.Patients/MethodsNumber of 25 patients with the diagnosis of DFSP through histological and immunostaining study was included. The slow‐Mohs was performed by excision of the tumor with margins accounting for 1–2 cm from both the tumor margins and three‐dimensional thickness. The obtained tissue margins were horizontally, and if any of the specimens was not margin‐free, the procedure was repeated. The patients' opinion about the procedure was assessed using Patient‐Observer Scar Assessment Scale (POSAS).ResultsNumber of 25 patients were included and followed for a median of 46.9 months. The median of the area of excision was 35.56 cm2, and the median clinical excision margins were 19 mm (tumor excision margins + thickness of the three‐dimensional excision). The surgery was performed once for 16 (64%), and postoperative skin closure within 5–7 days after the procedure was performed for 19 (76%) patients. None of the patients represented any recurrence. The patients' overall opinion and satisfaction POSAS score accounted for 2.3 ± 1.65 and 1.6 ± 0.59, respectively.ConclusionThe findings of the current study are in favor of slow‐Mohs surgery for the management of DFSP, while more extensive studies are strongly recommended for generalization of this procedure.
Family versus Non‐Family Firm Franchisors: Behavioural and Performance Differences
Authors: Chirico Francesco , Welsh Dianne H. B. , Ireland R. Duane , Sieger Philipp 
Published: February 2020

AbstractDrawing from resource‐based theory, we argue that family firm franchisors behave and perform differently compared to non‐family firm franchisors. Our theorizing suggests that compared to a non‐family firm franchisor, a family firm franchisor cultivates stronger relationships with franchisees and provides them with more training. Yet, we predict that a family firm franchisor achieves lower performance than a non‐family firm franchisor. We argue, however, that this performance relationship reverses itself when family firm franchisors are older and larger. We test our hypotheses with a longitudinal dataset including a matched‐pair sample of private U.S. family and non‐family firm franchisors.
Family understanding and communication about an adult relative’s mental health problem: A systematic narrative review
Authors: Gammage Rebecca J. , Nolte Lizette 
Published: February 2020

Accessible summaryWhat is known on the subject?

Adults who support an adult family member with a severe and enduring mental health problem often experience carer burden. Over time, this often negatively affects their mental and physical health and social well‐being.

Understanding and communicating about mental health problems in families can help to improve resilience and coping among both adults and children.

What does this paper add to existing knowledge?

We conducted a review of studies looking at how adult relatives understand and communicate about an adult family member's mental health problem.

The findings highlight that how relatives make sense of MHP is related to historical family relationships, their mental health literacy and whether they see themselves as a “carer” or not.

The findings also show that little research to date has explored how adult relatives talk with children about their parent's difficulties, and how the adults’ understanding might affect what children learn about the MHP.

What are the implications for practice?

There is a research gap to be addressed regarding family communication with children about parental mental health problems. This knowledge gap likely impacts family‐focused mental health nursing and therapy provision.

Mental health nursing, therapeutic and support workers and advocates are ideally positioned to assist relatives with improving their mental health literacy and confidence communicating about mental health, and to promote inclusion of relatives and children in interventions.

AbstractIntroductionRelatives are profoundly affected by an adult family member's severe and enduring mental health problem (MHP). The burdens of caring impact on adult relatives’ emotional, physical and social well‐being. How relatives make meaning and communicate about the MHP is thought to affect family talk about mental health, and this can impact family coping and well‐being.AimNo review has yet drawn together research about how adult relatives of people with severe and enduring MHP make meaning and communicate about their relatives’ difficulties. We aimed to address this gap.MethodWe conducted a systematic review of peer‐reviewed primary research. SCOPUS, PubMed, Psychnet, SCIE, Cochrane and CINAHL+ databases were searched.ResultsNineteen papers qualified for inclusion. Findings are organized under four themes: making meaning about the MHP and affected individual; conceptualizing the self in the presence of the MHP; meaning‐making processes underlying relatives’ well‐being outcomes; and relatives’ perspectives on family talk about the MHP.DiscussionHistorical relationships, caregiver identity and mental health literacy moderate relatives’ understanding and talk about the MHP.Implications for practicePsychoeducation and communication support for relatives should be provided by mental health practitioners. Future research should address familial communication about MHP, including with children.
The State of Inclusion With Students With Intellectual and Developmental Disabilities in the United States
Authors: Wehmeyer Michael L. , Shogren Karrie A. , Kurth Jennifer 
Published: February 2020

AbstractThis article describes the state of inclusion and inclusive practices with students with intellectual and developmental disabilities (I/DD) in the United States. It reviews the legislative history of the right to a free, appropriate public education for students with disabilities and the requirement in U.S. law for special education services to be provided in the least restrictive environment (LRE). Despite a focus on the LRE and appropriate supplementary aids and services to promote success in regular education environments for students with I/DD, students with I/DD are still educated largely in segregated classrooms and settings in the United States. However, a large and growing body of research suggests the positive benefits of inclusive education providing a compelling need for ongoing change to make inclusive placements the default for students with I/DD, consistent with the law. Research clearly suggests that inclusive placements benefit students with I/DD, and emerging research highlights that engagement and access to the general education curriculum is higher in inclusive vs. segregated settings. There is an ongoing need for the implementation of the policy establishing the right to education in the LRE for students with ID, and recent court cases suggesting the importance of an “appropriately ambitious” education program provide new direction for progress in inclusive practices.
The effect of gelatin and thymol‐loaded nanostructured lipid carrier on physicochemical, rheological, and sensory properties of sesame paste/date syrup blends as a snack bar
Authors: Baqeri Forod , Nejatian Mohammad , Abbaszadeh Sepideh , Taghdir Maryam 
Published: February 2020

AbstractThe development of a novel snack bar based on sesame paste (SP) and date syrup (DS) was investigated. The aim of this study was to evaluation the effects of SP/DS ratio and encapsulated thymol (thymol‐loaded nanostructured lipid carrier [TNLC]) on physicochemical, textural, rheological, and sensorial properties of snack bars. The effect of butylated hydroxytoluene (BHT), thymol, and TNLC showed that the addition of 100 ppm TNLC could improve the oxidative stability of SP/DS mixtures even better than BHT, while a higher concentration of TNLC had a negative effect. The unpleasant taste and odor of thymol could be overcome by its encapsulation in nanostructured lipid carriers. The textural properties of the formulations with different SP/DS ratios (1:2, 1:1, 2:1) and an overall concentration of 7 g of gelatin/kg of mixtures were evaluated. The texture profile analysis showed that the sample with an SP/DS ratio of 1:1 had higher hardness, adhesiveness, springiness, cohesiveness, and gumminess in comparison with the other ratios. From the sensory evaluation data, the bar prepared with an SP/DS ratio of 1:1 had the most acceptable texture. According to the results, the SP/DS ratio of 1:1 with gelatin and 100 ppm TNLC can be used in developing SP/DS blends as a highly acceptable functional food.
A novel septal protein of multicellular heterocystous cyanobacteria is associated with the divisome
Authors: Springstein Benjamin L. , Arévalo Sergio , Helbig Andreas O. , Herrero Antonia , Stucken Karina , Flores Enrique , Dagan Tal 
Published: February 2020

AbstractCyanobacteria are unique among the eubacteria as they possess a hybrid Gram phenotype, having an outer membrane but also a comparably thick peptidoglycan sheet. Furthermore, the cyanobacterial divisome includes proteins specific for both the Gram types as well as cyanobacteria‐specific proteins. Cells in multicellular cyanobacteria share a continuous periplasm and their cytoplasms are connected by septal junctions that enable communication between cells in the filament. The localization of septal junction proteins depends on interaction with the divisome, however additional yet unknown proteins may be involved in this process. Here, we characterized Alr3364 (termed SepI), a novel septal protein that interacts with the divisome in the multicellular heterocystous cyanobacterium Anabaena sp. strain PCC 7120. SepI localized to the Z‐ring and the intercellular septa but did not interact with FtsZ. Instead, SepI interacted with the divisome proteins ZipN, SepF and FtsI and with the septal protein SepJ. The inactivation of sepI led to a defect in cell filament integrity, colony and cell morphology, septum size, nanopore formation and peptidoglycan biogenesis, and inability to differentiate heterocysts. Our results show that SepI plays a role in intercellular communication and furthermore indicate that SepI functions in the coordination of septal junction localization during cell division.