bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance, metabolic and hormonal responses on the peripartum of grazing beef cows supplemented during the pre-partum
Authors: Ferreira Matheus Fellipe de Lana , Rennó Luciana Navajas , Detmann Edenio , Paulino Mário Fonseca , Filho Sebastião de Campos Valadares , Moreira Samira Silveira , Martins Hudson Caio , de Oliveira Bruno Inácio Correa , Marquez Julia Avansi , Cidrine Isabela de Paula 
Published: December 2019

Abstract

Background: Strategies for feeding supplements during the pre-partum are usually adopted because nutritional status upon calving is the main factor to affect reproductive performance. Metabolic parameters that relate nutritional status to physiological processes can be used to better understand the effects of supplementation. This study evaluated the effects of 60-day pre-partum energy-protein supplementation on performance, metabolic and hormonal responses during the peripartum of grazing beef cows. Thirty-eight pregnant multiparous Nellore cows were assigned to a completely randomized design with two treatments: control with no supplement and supplementation on the last 60 gestation days (1.5 kg/d). Results: The supplemented cows had higher ADG during the pre-partum (P<0.10), but ADG did not differ between treatments during the postpartum. Nonsupplemented cows’ ADG did not change during these periods (P>0.10). Supplementation did not affect (P>0.10) BCS and calves’ BW upon calving on days 45 and 90, milk yield and composition (P>0.10). No differences (P>0.10) were found for forage intake and neutral detergent fiber digestibility. The intake and digestibility of CP and OM increased (P<0.10) with supplementation. An interaction occurred (P>0.10) between supplementation and peripartum days for BUN, βHB, T3 and T4. Concentration of others blood parameters significantly changed (P<0.10) along peripartum days. There was no difference in pregnancy rates and days from calving to conception among treatments (P>0.10). Conclusions: Providing energy-protein supplement for grazing Nellore cows on the last 60 d of gestation improve energy balance during pre-partum, however, no carryover effects are seen for pre-partum supplementation on post-partum physiological responses. Keywords: nutrition, metabolism, parturition, Zebu
Influence of Interleukin-18 and Interleukin-17 Receptor A gene polymorphisms on the risk of thyroid cancer among Chinese Han population
Authors: Yin Yanhai , Li Fen , Tong Liangqian , Wang Chaoqun , Liang Kun , Chen Chunru , Dai Ruqi , Yuan Bo 
Published: December 2019

Abstract
Background Thyroid cancer (TC) is a common endocrine pathology with an increasing incidence worldwide. It has been reported that high genetic impact is involved in the pathogenesis of TC, as well as cytokines, especially the interleukins play a crucial role in it. This study was designed to detect the association of IL-18 and IL-17RA polymorphisms with TC risk.Methods This case-control study conducted 365 TC patients and 503 healthy controls from Chinese Han population. Three selected SNPs (IL-18 rs360718, IL-18 rs1946519, and IL-17RA rs4819554) were genotyped to investigate the possible association of the polymorphisms with the risk of TC. Multifactor dimensionality reduction (MDR) was used to analyze the interactions of SNP-SNP.Results IL-17RA rs4819554 was associated with the decreased risk of TC under dominant model (OR = 0.76, 95% CI = 0.56-0.99, p = 0.04). IL-18 rs360718 significantly decreased the risk at age ≤ 44 years (C vs. A, OR = 0.63, 95% CI = 0.41-00.97, p = 0.033; CC vs. AA, OR = 0.12, 95% CI = 0.01-0.91, p = 0.040). On the contrast, among people older than 44 years, IL-18 rs1946519 (C vs. A, OR = 1.77, 95% CI = 1.03-3.06, p = 0.040) shown an increased risk with TC. MDR analysis revealed a positive interaction between the SNPs.Conclusion The present study firstly demonstrated that IL-18 rs360718, rs1946519 and IL-17RA rs4819554 polymorphisms might be related to thyroid cancer. The results were significantly worthy of further validation by larger studies.
Factors leading to increased operational costs in a public hospital in São Paulo, Brazil
Authors: de Souza Janaína Monique Ferreira , Pereira Adriano J , Silva Eliezer 
Published: December 2019

Abstract
Objectives - To quantify the operational costs of a municipal public hospital in the city of São Paulo (Brazil) and to identify factors that led to cost increases during the year of 2016 using the absorption method. Method - This was a retrospective study conducted between January and December of 2016 at Vila Santa Catarina Municipal Hospital, a public tertiary hospital in São Paulo, Brazil. Results - We identified and analyzed a total of 8702 inpatient data. Average day cost per patient was US$ 949, with a median of US$ 1,825, and a total operating cost of US$ 48,743,847. Transplant patients showed the highest median costs, while pregnant women had the lowest median costs. The cost for 6083 (69.9%) of the 8702 hospitalized patients was above the mean cost of US$3,068 registered for 2016. Age was associated with a 6.6% increase in cost for each one-year increase in age, while the cost associated with female patients was 1.1 times that of men. Patients who died in the hospital were 8 times more likely to cost more than patients who were discharged from the hospital. Oncology, transplant, and clinical-surgical patients had 18.8 times (p <0.001), 15.8 times (p <0.001) and 13.7 times (p <0.001) the cost of patients in the maternity unit, respectively. Conclusion - We identify the operating costs of the Vila Santa Catarina Municipal Hospital, where the average cost for the operation of the unit was US$ 133.179. The cost per patient was US$ 1,825.91. We also concluded as to the second objective that the cost increase factors were age and death.
Identification and functional characterization of NbMLP28, a novel MLP-like protein 28 enhancing Potato virus Y resistance in Nicotiana benthamiana
Authors: song liyun , Wang Jie , Jia Haiyan , Kamran Ali , Qin Yuanxia , Liu Yingjie , Hao Kaiqiang , Han Fei , Zhang Chaoqun , Li Bin , Li Yongliang , Shen Lili , Wang Fenglong , Wu Yuanhua , Yang Jinguang 
Published: December 2019

Abstract
Background: Major latex proteins (MLPs) belong to the MLP subfamily in Bet v 1 protein family and respond to both biotic and abiotic stresses, which play critical roles in plant disease resistance. As the type species of widely distributed and economically devastating Potyvirus, Potato virus Y (PVY) is one of the major constraints to important crop plants including tobacco ( Nicotiana benthamiana ) worldwide. Despite the great losses owing to PVY infection in tobacco, there is no previous study investigating the potential role of MLPs in developing resistance to viral infection.Results: In this study, for the first time we have identified and functionally analyzed the MLP-like protein 28 from N. benthamiana , denoted as NbMLP28 and investigated its role in conferring resistance to N. benthamiana against PVY infection. NbMLP28 was localized to the plasmalemma and nucleus, with the highest level in the root. NbMLP28 gene was hypothesized to be triggered by PVY infection and was highly expressed in jasmonic acid (JA) signaling pathway. Further validation was achieved through silencing of NbMLP28 through virus-induced gene silencing (VIGS) that rendered N. benthamiana plants more vulnerable to PVY infection, contrary to overexpression that enhanced resistance.Conclusions: Taken together, this is the first study describing the role of NbMLP28 in tobacco against PVY infection and provide a pivotal point towards obtaining pathogen-resistant tobacco varieties through constructing new candidate genes of MLP subfamily.
MORFOLOGI DAN ANATOMI Chrysanthemum morifolium Ramat. var. puspita nusantara dan var. tirta ayunisertaChrysanthemum indicum L.var. mustika kaniya
Authors: Dalaila Isvana , Kusrinah Kusrinah , Lianah Lianah 
Published: December 2019

<p><em>Chrysanthemum including ornamental plant commodities are much-loved community. Chrysanthemum has a high economic value and potential to be developed. The diversity of morphological and anatomical characters is not currently widely practiced. This study aims to determine the morphological and anatomical characteristics of C. morifolium Ramat. var. puspitanusantara, and var. tirtaayuni and C. indicum L. var. mustikakaniya. Sampling by purposive random. The study was conducted in May - June 2017 in Kenteng Village, Bandungan District, Semarang District. The results showed that the results showed that C. morifolium Ramat var. puspitanusantara and var. tirtaayuni and C. indicum L. var. mustikakaniya have variations of morphology, especially on leaves and flowers, variations in leaf organ form, and base. Variations of flowering organs include the number of flowers per stem, the number of ribbon flowers, and the freshness of the flower. Anatomical characters based on tissue arrangement of stem and leaf organs have similarities.</em></p><p> </p>
Pengaruh Kepadatan Medium MS0 terhadap Perkecambahan Biji Jagung (Zea mays L., Var.” Lokal”) secara In Vitro
Authors: Istiqhomah Saniatul , Mukaromah Arnia Sari , Rusmadi Rusmadi 
Published: December 2019

<p><em>This study aims to determine the effect of MS0 medium density on maize in vitro seed germination.</em><em> </em><em>The sample used in this study is corn kernels</em><em> from local variety</em><em> (Zea mays L. var. “Lokal”). This research </em><em>was</em><em> an experimental research with a quantitative method approach. The study used a </em><em>Rancangan Acak Lengkap</em><em> (</em><em>RAL</em><em>) with one treatment factor </em><em>that is </em><em>medium density MS0 with a degree of agar concentration </em><em>are </em><em>4 gram, 6 gram, 8 gram </em><em>and</em><em> 10 gram </em><em>each concentration repeated </em><em>3 </em><em>times</em><em>. Data analysis uses the One Way Analysis of Variant (ANOVA) test</em><em> and </em><em>if it shows significant results</em><em>, test continued</em><em> </em><em>to</em><em> BNJ </em><em>test </em><em>(Beda Nyata Jujur). The best growth results occur at low level medium density (agar 4 gram) </em><em>based on parameters </em><em>days </em><em>of </em><em>emerged buds, plant height, number of roots, number of leaves and wet weight of corn plantlets. Uji ANOVA </em><em>showed that </em><em> </em><em>F value calculated 41.333 </em><em>bigger than</em><em> F </em><em>value </em><em>ta</em><em>b</em><em>l</em><em>e</em><em> </em><em>that is</em><em> 4.07 </em><em>with </em><em>significance level 0,05. This</em><em> result</em><em> shows that H0</em><em> is</em><em> </em><em>rejected and</em><em> H</em><em>a </em><em>is accepted. The results are continued with the </em><em>BNJ</em><em> </em><em>test</em><em>. BNJ </em><em>test obtained significantly different results on germination of corn kernels in all treatments. </em><em>The wet weight of corn plantlets has a high influence on the organs (roots, stems and leaves) of plants</em><em>.</em><em> </em><em>If the wet weight is high, the plant growth is significant and vice versa.</em></p>
Technogenic metallic elements in biomass and their effects on biomass product properties
Authors: Baltrėnaitė Edita , Baltrėnas Pranas , Huisingh Donald 
Published: December 2019

AbstractAvailability of clean water and sustainable management of water are among the 17 global ‘Sustainable Development Goals,’ established by the United Nations. The increasing technogenesis-related pollution causes increases the concentrations of many metallic elements (MEs) throughout the biosphere. The syngenetic bio-incorporation of MEs changes the biomass's chemical and physical composition and impacts the quality of products, e.g. biochar (BC). This has impacts upon BCs potential for adsorption of water pollutants. While direct, engineered modification of BC can improve its adsorption characteristics, the more indirect alterations of BC composition, based on syngenetic elements, also modifies BCs adsorption functionality. The objective of this study was to identify the characteristics of syngenetically accumulated MEs in ligneous biomass on the adsorptive properties of the BCs derived from such modified biomasses. The authors of this paper investigated the syngenetic pathway of MEs into the ligneous biomass and provided an overview of the forms and quantities of MEs in the biomass and their transformation to BC. The early results of the effects of syngenetic MEs on the adsorptive properties of BC from ligneous biomass are presented. The results suggest that additional syngenetical MEs result in increases in the adsorptive properties of the resultant biomass-derived BCs.
Urban agriculture as a keystone contribution towards securing sustainable and healthy development for cities in the future
Authors: Skar S. L. G. , Pineda-Martos R. , Timpe A. , Pölling B. , Bohn K. , Külvik M. , Delgado C. , Pedras C. M.G. , Paço T. A. , Ćujić M. , Tzortzakis N. , Chrysargyris A. , Peticila A. , Alencikiene G. , Monsees H. , Junge R. 
Published: December 2019

Abstract
Research and practice during the last 20 years has shown that urban agriculture can contribute to minimising the effects of climate change by, at the same time, improving quality of life in urban areas. In order to do so most effectively, land use and spatial planning are crucial so as to obtain and maintain a supportive green infrastructure and to secure citizens' healthy living conditions. As people today trend more towards living in green and sustainable city centres that can offer fresh and locally produced food, cities become again places for growing food. The scope of urban agriculture thereby is to establish food production sites within the city's sphere; for example, through building-integrated agriculture including concepts such as aquaponics, indoor agriculture, vertical farming, rooftop production, edible walls, as well as through urban farms, edible landscapes, school gardens and community gardens. Embedded in changing urban food systems, the contribution of urban agriculture to creating sustainable and climate-friendly cities is pivotal as it has the capacity to integrate other resource streams such as water, waste and energy. This article describes some of the current aspects of the circular city debate where urban agriculture is pushing forward the development of material and resource cycling in cities.
Kinetics of sonophotocatalytic degradation of an anionic dye nigrosine with doped and undoped zinc oxide
Authors: Kumawat Srishti , Meghwal Kiran , Kumar Sudhish , Ameta Rakshit , Ameta Chetna 
Published: December 2019

Abstract
The current research focuses on the photocatalytic, sonocatalytic and sonophotocatalytic degradation of nigrosine dye with nitrogen-doped and undoped zinc oxide powders. The sonophotocatalytic degradation of dye was found to occur at a higher rate than during photo- or sonocatalytic processes. Nitrogen-doped and undoped zinc oxide powders were synthesized by a wet chemical method. Further, scanning electron microscopy (FESEM), electron dispersive X-ray (EDX), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV-VIS spectroscopy (UV-VIS) and transmission electron microscopy (TEM) were used for the characterization of N-doped ZnO. The kinetics of nigrosine degradation were also studied and the results indicated that the degradation kinetics of nigrosine followed the first-order kinetics. The rate constant and the percentage of degradation were found to be highest, 7.33 × 10−4 (s−1) and 92% respectively, for sonophotocatalytic process after 90 min of reaction. Due to an increase in the available surface area or active sites of the catalyst, a higher rate constant and degradation efficiency was observed in the sonophotocatalytic system than in the photocatalysis system.
Who owns the beach? Conflicts over public spaces in a tourism economy
Authors: Palmer Christian Tobler 
Published: December 2019

ABSTRACT
As the town of Canoas has transitioned from a fishing village to a growing tourist town, the beaches have become the center of economic and cultural activities. The occupation of beaches by small scale vendors has created conflict among different groups including hotel developers, surfers, migrants, and local politicians. These groups have different aesthetics and ideas of public space, creating conflicting over what beaches should look like and how they should be used. This research analyzes the day to day practices through which different groups claim beach spaces and the ways these claims are challenged. These conflicts illustrate the struggles over environmental governance between municipal, state, and federal governments. This research contextualizes the occupation of public space in a longer legal history of land occupation and environmental protection in Brazil, examining the constant negotiations between traditional and legal systems of land rights.
Keywords: Beach. Public Spaces. Tourism. Brazil.

RESUMO
Desde que a cidade de Canoas passou de uma vila de pescadores para uma cidade turística crescente, as praias se tornarem o centro de atividades culturais e econômicas. Esta ocupação de praias por vendedoras criou conflitos entre diferentes grupos incluindo empresários hoteleiros, surfistas, migrantes e políticos locais. Estes grupos têm diferentes estética e ideias de espaço público, criando conflito de como as praias devem aparecer e como elas deverem ser usadas. Esta pesquisa analisa as práticas cotidianas através das quais diferentes grupos ocupam espaços de praia e como estas ocupações são contestadas. Esses conflitos ilustram a briga sobre governança ambiental entre o poder público municipal, estadual e federal. Esta pesquisa contextualiza a ocupação do espaço público em uma longa história jurídica de ocupação do terra e proteção ambiental no Brasil, examinando as constantes negociações entre os sistemas tradicionais e jurídicos de direitos à terra.
Palavras-Chave: Praia. Espaço Público. Turismo. Brasil.
Adjunctive Immunotherapeutic Efficacy of N-Formylated Internal Peptide of Mycobacterial Glutamine Synthetase in Mouse Model of Tuberculosis
Authors: Mir Shabir Ahmad , Sharma Sadhna 
Published: December 2019

Background:
Host-directed therapies are a comparatively new and promising method for
the treatment of tuberculosis. A variety of host pathways, vaccines and drugs have the potential to
provide novel adjunctive therapies for the treatment of tuberculosis. In this connection, we have
earlier reported the immunotherapeutic potential of N-formylated N-terminal peptide of glutamine
synthetase of Mycobacterim tuberculosis H37Rv (Mir SA and Sharma S, 2014). Now in the present
study, we investigated the immunotherapeutic effect of N-terminally formylated internal-peptide 'f-
MLLLPD' of mycobacterial glutamine synthetase (Rv2220) in mouse model of tuberculosis.

Methods:
The N-terminally formylated peptide, f-MLLLPD was tested for its potential to generate
Reactive Oxygen Species (ROS) in murine neutrophils. Further, its therapeutic effect alone or in
combination with anti-tubercular drugs was evaluated in mouse model of tuberculosis.

Results:
The f-MLLLPD peptide treatment alone and in combination with ATDs reduced the
bacterial load (indicated as colony forming units) in lungs of infected mice by 0.58 (p<0.01) and
2.92 (p<0.001) log10 units respectively and in their spleens by 0.46 (p<0.05) and 2.46 (p<0.001)
log10 units respectively. In addition, the observed histopathological results correlated well with the
CFU data.

Conclusion :
The results of the current study show that f-MLLLPD peptide confers an additional
therapeutic efficacy to the anti-tuberculosis drugs.
Updated Efficient Area -Carry Select Adder for Low Complexity D LATCH Configuration by disease identification in brain tumor hyper spectral image
Authors: V.V Teresa , B Anand. 
Published: December 2019

Objective:
In this research work presents an efficient way Carry Select Adder (CSLA) performance and estimation. The CSLA is utilized in several system to mitigate the issue of carry propagation delay that is happens by severally generating various carries and to get the sum, select a carry because of the uses of various pairs of RCA to provide the sum of the partial section also carry by consisting carry input but the CSLA isn't time economical, then by the multiplexers extreme total and carry is chosen in the selected section.

Methodology:
The fundamental plan of this work is to attain maximum speed and minimum power consumption by using Binary to Excess-1. Convertor rather than RCA within the regular CSLA. Here RCA denotes the Ripple Carry Adder section. At the span to more cut back the facility consumption, a method of CSLA with D LATCH is implemented during this research work. The look of Updated Efficient Area -Carry Select Adder (UEA-CSLA) is evaluated and intended in XILINX ISE design suite 14. 5 tools. This VLSI arrangement is utilized in picture preparing application by concluding the cerebrum tumor discovery.

Conclusion:
In this study, medicinal pictures estimation, investigation districts in the multi phantom picture isn't that much proficient to defeat this disadvantage here utilized hyper spectral picture method is presented a sifting procedure in VLSI innovation restriction of cerebrum tumor is performed Updated Efficient Area - Carry Select Adder propagation result dependent on Matrix Laboratory in the adaptation of R2018b.
Coumarin-Fatty Acid Conjugates as Potential ERα/AKT-1 Antagonists for ER Positive Breast Cancer
Authors: Selvaraj Jubie , John Jameera B.A. , Joghee Nanjan M. , Antony Justin , Wadhwani Ashish , Natarajan Jawahar 
Published: December 2019

Background: :
Current drugs used for the treatment of hormone-dependent breast cancer function as
anti-estrogens in the breast, in addition to Estrogen Receptor (ER) agonists in the uterus, thus elevate a woman’s
risk of developing uterine cancer. This is due to the lack of selective binding and partial agonistic effect of these
drugs towards estrogen receptors. In recent years, therefore, researchers have turned their attention towards
antiestrogens devoid of these agonist properties and thus have a mechanism of action different from the existing
drugs.

Objective::
In this context, we report here the design, development and in vitro evaluation of some novel pharmacophores
containing coumarin and fatty acid scaffolds for their anti-breast cancer activity.

Methods: :
A library of coumarin-fatty acid conjugates was designed using structure-based drug design approach.
The conjugates which have shown good in silico results were then synthesized, characterized and evaluated for
their anti-breast cancer activity by MTT assay, Apoptotic assay, Cell proliferation assay, Estrogen binding assay
and Gene expression study.

Results:
Out of the fifteen compounds screened, two compounds, SAC-2 and LNAC-2, showed good activity
with IC50 values 22µg/ml, 25μg/ml, respectively. These compounds suppressed the proliferation of ER overexpressed
MCF-7 cells, increased ERα degradation and hence inactivate the ERα pathway. ER binding assay and
gene expression RT-PCR study reveal that SAC-2 downregulated the expression of ERα receptor and AKT-1 gene.

Conclusion::
Compound SAC-2 is a good antagonist to ER and hence has a potential for treating breast cancer
and other cancers where AKT plays an important role.