bluuebunny/crossref_metadata_2025_split huggingface dataset:
From language mixing to fused lects: The process and its outcomes
Authors: Auer Peter , Hakimov Nikolay 
Published: May 2020

Objectives: In this introductory article, we advance a unified framework for analysis and interpretation of transfer of overt linguistic structure in language contact situations. Our goal is to demonstrate that fusion, a process whereby results of bilingual practices become grammaticized and conventionalized (see Auer 1999, 2014), is a gradient phenomenon, which applies to a large spectrum of language contact phenomena. Our additional objective is to situate the contributions to this special issue in the context of this approach. Design: The article defines fusion as a central concept underlying the proposed framework, identifies the basic dimensions of fusion and showcases its various outcomes by reviewing extensive contact linguistics literature and the contributions to this special issue. Data and Analysis: In our analysis of contact linguistic phenomena, we draw on available linguistic descriptions of pertinent contact varieties and bilingual practices. We examine these phenomena in terms of fusion and in relation to its three basic dimensions. Findings: This article shows that fusion, being a gradient multifaceted phenomenon, should be analyzed along the following dimensions: (a) the amount of structure affecting the receiving language, (b) the degree of sedimentation of bilingual patterns, (c) the degree of fusional compartmentalization. Significance: The present article identifies and describes manifold outcomes of fusion in terms of three basis dimensions. These dimensions enable one to distinguish fused lects from language mixing and other bilingual phenomena and need therefore be incorporated in future linguistic descriptions and analyses of fused lects.
Readability of Printed Online Education Materials on Pituitary Tumors: Untangling a Web of Complexity
Authors: Ye Michael J. , Alwani Mohamedkazim M. , Harper Jonathan L. , Buren Lauren M. Van , Bandali Elhaam H. , Illing Elisa A. , Shipchandler Taha Z. , Ting Jonathan Y. 
Published: May 2020

Background Patients are increasingly turning to the internet for health education. Due to the complex pathophysiology, clinic-diagnostic profile, and management spectrum of pituitary tumors, an evaluation of the readability of printed online education materials (POEMs) regarding this entity is warranted. Objective (1) To apply established readability assessment tools to internet search results on the topic of pituitary tumors. (2) To identify sources of complexity in order to guide the creation POEMs that are in line with the reading level of the target audience. Methodology: After independent, neutral internet search for the phrase “pituitary tumor,” the first 100 results were subjected to inclusion criteria matching. Analysis was performed using 5 readability assessment tools including Flesch Reading Ease (FRE), Flesch–Kincaid Grade Level (FKGL), Gunning-Fog Score (GFS), Coleman–Liau Index (CLI), and Simple Measure of Gobbledygook (SMOG). Results A total of 82 websites met inclusion criteria. All websites were found to be at a higher reading level ( P < .01) than the United States Department of Health and Human Services (USDHHS) recommended sixth-grade level. Mean readability scores were as follows: FRE, 38.79; FKGL, 11.27; GFS, 12.83; CLI, 17.31; SMOG, 12.12. Intergroup comparison between FKGL, GFS, CLI, and SMOG yielded that CLI was significantly higher ( P < .03). No significant differences in readability were noted between academic and other websites. Conclusion There is a significant misalignment between the reading level of patients and the readability of pituitary tumor POEMs. This may lead patients to misconceive their diagnoses, management options, and prognosis.
Outcomes associated with apixaban vs warfarin in patients with renal dysfunction
Authors: Hanni Claudia , Petrovitch Elizabeth , Ali Mona , Gibson Whitney , Giuliano Christopher , Holzhausen Jenna , Makowski Charles , Pallisco Amy , Patel Nisha , Sutter Denise , To Long , Yost Raymond 
Published: May 2020

Abstract
Apixaban in patients with impaired renal function is supported by limited data. Landmark clinical trials evaluating apixaban in patients with atrial fibrillation and/or acute venous thromboembolism excluded patients with creatinine clearance (CrCl) &lt;25 mL/min. This multicenter, retrospective chart review was conducted to evaluate the safety and effectiveness of apixaban compared with warfarin in patients with CrCl &lt;25 mL/min. Included patients were newly initiated on apixaban or warfarin for at least 45 days with a CrCl &lt;25 mL/min. Patients were evaluated for thrombosis and bleeding outcomes 6 months following initiation of anticoagulation. The primary outcome was the time to first bleeding or thrombosis event. A total of 128 patients met inclusion criteria in the apixaban group and 733 patients in the warfarin group. Time to first bleeding or thrombosis event was significantly different between the apixaban and warfarin groups. Cox proportional hazards model was conducted to control for potential confounding factors for the primary outcome. After controlling for atrial fibrillation and coronary artery bypass grafting, risk of thrombotic and bleeding events was lower in the apixaban group (hazard ratio, 0.47; 95% confidence interval, 0.25-0.92). There was not a statistical difference between time to thrombosis (83 days vs 54 days, P = .648), rate of thrombosis (5.5% vs 10.3%, P = .08), time to bleeding (46 days vs 54 days, P = .886), or rate of bleeding (5.5% vs 10.9%, P = .06). The severity of bleeding and thrombotic events was not different between groups. Apixaban may serve as a reasonable alternative compared with warfarin in patients with severe renal dysfunction.
Creative Chinese Countryside? Township-Village Enterprises as Incubators
Authors: Liu Mengchuan , Wang Yi-Wen , Nolf Christian 
Published: May 2020

AbstractSince the turn of the century, creative industries have displayed considerable power in transforming the social and economic landscapes of most global metropolises, including such Chinese mega-cities as Beijing and Shanghai. However, the story of creative industries does not end there. Recent studies have focused on the role of creative sector in the countryside. It has been argued that the creative sector can effectively contribute to diversifying socio-economic development in rural areas by increasing employment, enhancing the quality of life, and promoting social inclusion and community development. With the aim to chart new paths for China’s rural revitalisation and address the country’s ‘three rural issues’ (i.e. agriculture, rural areas and farmers), this paper examines the potentials and challenges to developing the creative sector in rural China. It first reviews the academic debate about expanding the development of creative industries from urban to rural areas. Drawing on the research and classification of creative industries in rural Western Ireland, this study identifies industries characterised by ‘content creation and production’ and ‘creative design services’, which would have potential in rural China. The major impediments to and crucial factors for developing rural creative industries in China are investigated and appraised within the framework of ‘creative people, creative place, and creative support’. After analysing emerging practices in Jiangsu Province, this paper highlights the potential of abandoned industrial complexes in rural parts of China’s coastal regions, which can act as incubators for creative industries. Those former manufacturing plants are the remains of township-village enterprises (TVEs), which constituted part of China’s flagship policy for rural regeneration in the 1980s. Not only do they have special architectural attributes favourable for creative production, but also represent the socio-economic entity of the village collective and are the carriers of cultural meanings and memories. This paper concludes with a set of recommendations for both public and private sectors. It calls for a more proactive stance from governments to promote the creative sector in rural areas and revitalise rural economies and communities through the reuse or regeneration of former TVEs.
Grimy Heritage: Organic Bar Streets in Shanghai and Tokyo
Authors: Farrer James 
Published: May 2020

AbstractEvery city has built environments that are largely regarded as eyesores, for aesthetic, social, or moral reasons. Urban nightlife streets are examples of such ‘grimy heritage’. Not only shabby and disorderly, they harbour forms of commercial sex, drinking cultures, and ephemeral nightlife cultures that many city residents and government officials consider undesirable. Sometimes their built forms are regarded as the enemy of genuine heritage architecture, since they obscure more solid, carefully designed structures around them. However, in many cities, organic nightlife streets—developing in such spaces precisely because they were derelict or poorly regulated—serve important social functions as spaces of creativity and community formation. This paper examines the ways that such ‘grimy heritage’ has developed in Shanghai and Tokyo, using examples from ethnographic research and historical sources, and addressing the question of the contribution of the ‘grimy heritage’ to authentic, urban social life.
Temporal expression patterns of fruit-specific α- EXPANSINS during cell expansion in bell pepper (Capsicum annuum L.)
Authors: Mayorga-Gómez Andrés , Nambeesan Savithri U. 
Published: May 2020

Abstract
Background
Expansins (EXPs) facilitate non-enzymatic cell wall loosening during several phases of plant growth and development including fruit growth, internode expansion, pollen tube growth, leaf and root development, and during abiotic stress responses. In this study, the spatial and temporal expression patterns of C. annuum α- EXPANSIN (CaEXPA) genes were characterized. Additionally, fruit-specific CaEXPA expression was correlated with the rate of cell expansion during bell pepper fruit development.

Results
Spatial expression patterns revealed that CaEXPA13 was up-regulated in vegetative tissues and flowers, with the most abundant expression in mature leaves. Expression of CaEXPA4 was associated with stems and roots. CaEXPA3 was expressed abundantly in flower at anthesis suggesting a role for CaEXPA3 in flower development. Temporal expression analysis revealed that 9 out of the 21 genes were highly expressed during fruit development. Of these, expression of six genes, CaEXPA5, CaEXPA7, CaEXPA12, CaEXPA14 CaEXPA17 and CaEXPA19 were abundant 7 to 21 days after anthesis (DAA), whereas CaEXPA6 was strongly expressed between 14 and 28 DAA. Further, this study revealed that fruit growth and cell expansion occur throughout bell pepper development until ripening, with highest rates of fruit growth and cell expansion occurring between 7 and 14 DAA. The expression of CaEXPA14 and CaEXPA19 positively correlated with the rate of cell expansion, suggesting their role in post-mitotic cell expansion-mediated growth of the bell pepper fruit. In this study, a ripening specific EXP transcript, CaEXPA9 was identified, suggesting its role in cell wall disassembly during ripening.

Conclusions
This is the first genome-wide study of CaEXPA expression during fruit growth and development. Identification of fruit-specific EXPAs suggest their importance in facilitating cell expansion during growth and cell wall loosening during ripening in bell pepper. These EXPA genes could be important targets for future manipulation of fruit size and ripening characteristics.
Factors related to disagreement between self-reported versus objective measurement of allergen sensitization at a tertiary pediatric center in Beijing, China
Authors: Miao Qing , Xiang Li , Guan Hui , Liu Yongge , Li Zhen , Ren Yixin , Xu Wei 
Published: May 2020

Abstract
Background
The objectives of present study were to examine the level of disagreement between self-reported and objective measurement of sensitization to common inhalant allergens, and to explore the potential risk factors that might contribute to this discrepancy.

Methods
A total of 215 children were enrolled from pediatric clinics at a tertiary pediatric center in Beijing, China. A survey questionnaires regarding self-perceived sensitization was completed by participants’ parents/caregiver, meanwhile, skin prick testing(SPT) was performed as objective assessment of sensitization. Extent of agreement between self-reported versus SPT-measured sensitization to individual allergen was calculated using Cohen’s kappa (κ) coefficient. Multivariable regression analyses were used to determine the factors associated with discrepancy between self-reported and objective measurement of sensitization.

Results
119(55.3%) patients have reported to be sensitized to at least one of inhalant allergen, whereas 167(77.7%) patients had a positive skin testing response. Agreement between self-perceived and actual aeroallergen sensitization was moderate for mites(κ = 0.518) and grass pollen mix(κ = 0.451), moreover, fair agreement was observed for mold(κ = 0.316) and cockroach(κ = 0.297), respectively. There was a least agreement between perceived and actual sensitization observed for pet dander, with a kappa coefficient of 0.005. Subjects’ age, atopy history, ownership of pet may increase the risk of disagreement, moreover, background factors of informant, like: age, education level, and the relationship with enrolled subjects, were linked to the incidence of disagreement between self-reported sensitization in comparison with SPT results.

Conclusion
Questionnaire-based self-assessment is easy way to collect clinical information on allergen sensitization; however, the accuracy of questionnaire-derived information is more likely to be influenced by respondent’s background factors. The information from the questionnaire report is considered to be more reliable when in combination with objective assessment of sensitization, including blood IgE testing and SPT.
Conscious sedation for the management of dental anxiety in third molar extraction surgery: a systematic review
Authors: Melini Matteo , Forni Andrea , Cavallin Francesco , Parotto Matteo , Zanette Gastone 
Published: May 2020

Abstract
Background
Dental anxiety is a condition associated with avoidance of dental treatment and increased medical and surgical risks. This systematic review aims to summarize available evidence on conscious sedation techniques used for the management of Dental anxiety in patients scheduled for third molar extraction surgery, to identify best approaches and knowledge gaps.

Methods
A comprehensive search was conducted including MEDLINE/Pubmed, EMBASE, SCOPUS, clinicaltrials.gov and the Cochrane Database of Systematic Reviews through March 2019. Only randomized controlled trials were included. PRISMA guidelines were followed. Risk of bias was appraised as reported in the Cochrane Handbook for Systematic Reviews of Interventions.

Results
Seventeen RCTs with a total of 1788 patients were included. Some aspects limited the feasibility of a meaningful meta-analysis, thus a narrative synthesis was conducted. Conscious sedation was associated with improvement in Dental anxiety in six studies. One study reported lower cortisol levels with midazolam vs. placebo, while another study found significant variation in perioperative renin levels with remifentanil vs. placebo.

Conclusions
This review found inconclusive and conflicting findings about the role of Conscious sedation in managing Dental anxiety during third molar extraction surgery. Relevant questions remain unanswered due to the lack of consistent, standardized outcome measures. Future research may benefit from addressing these limitations in study design.
Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature review
Authors: Tohyama Taiji , Sakamoto Katsunori , Tamura Kei , Nakamura Taro , Watanabe Jota , Wakisaka Hiroyuki , Takada Yasutsugu 
Published: May 2020

Abstract
Background
The most common sites of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been reported to be the liver, lung, bone, and adrenal glands, but there have also been many reports of cases of multiple recurrence. The prognosis after recurrence is poor, with reported median survival after recurrence of HCC ranging from 9 to 19 months. Here, we report a case of long-term survival after recurrence of pharyngeal metastasis following living-donor liver transplantation (LDLT) for HCC within the Milan criteria, by resection of the metastatic region and cervical lymph node dissection.

Case presentation
A 47-year-old man with a Model End-stage Liver Disease (MELD) score of 11 underwent LDLT for HCC within the Milan criteria for liver cirrhosis associated with hepatitis B virus infection, with his 48-year-old elder brother as the living donor. One year and 10 months after liver transplantation, he visited a nearby hospital with a chief complaint of discomfort on swallowing. A pedunculated polyp was found in the hypopharynx, and biopsy revealed HCC metastasis. We performed pharyngeal polypectomy. Two years later, cervical lymph node metastasis appeared, and neck lymph node dissection was performed. Although recurrence subsequently occurred three times in the grafted liver, the patient is still alive 12 years and 10 months after recurrence of pharyngeal metastasis. He is now a tumor-free outpatient taking sorafenib.

Conclusion
It is necessary to recognize that the nasopharyngeal region is a potential site of HCC metastasis. Prognostic improvement can be expected with close follow-up, early detection, and multidisciplinary treatment, including radical resection.
Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions
Authors: Pandey Priyanka , Anani Waseem Q. , Pugh Tina , Gottschall Jerome L. , Denomme Gregory A. 
Published: May 2020

Abstract
Background
Typically minor ABO incompatible platelet products are transfused without any incident, yet serious hemolytic transfusion reactions occur. To mitigate these events, ABO ‘low titer’ products are used for minor ABO incompatible transfusions. We sought to understand the role of IgM/IgG and complement activation by anti-A on extravascular hemolysis.

Methods
Samples evaluated included (i) Group O plasma from a blood donor whose apheresis platelet product resulted in an extravascular transfusion reaction, (ii) Group O plasma from 12 healthy donors with matching titers that activated complement (N = 6) or not (N = 6), and (iii) Group O sera from 10 patients with anti-A hemolysin activity. A flow cytometric monocyte erythrophagocytosis assay was developed using monocytes isolated by immunomagnetic CD14-positive selection from ACD whole blood of healthy donors. Monocytes were frozen at − 80 °C in 10% dimethyl sulfoxide/FBS and then thawed/reconstituted on the day of use. Monocytes were co-incubated with anti-A-sensitized fluorescently-labeled Group A1 + RBCs with and without fresh Group A serum as a source of complement C3, and erythrophagocytosis was analyzed by flow cytometry. The dependency of IgM/IgG anti-A and complement C3 activation for RBC erythrophagocytosis was studied. Anti-A IgG subclass specificities were examined for specific samples.

Results
The plasma and sera had variable direct agglutinating (IgM) and indirect (IgG) titers. None of 12 selected samples showed monocyte-dependent erythrophagocytosis with or without complement activation. The donor sample causing a hemolytic transfusion reaction and 2 of the 10 patient sera with hemolysin activity showed significant erythrophagocytosis (> 10%) only when complement C3 was activated. The single donor plasma and two sera demonstrating significant erythrophagocytosis had high IgM (≥ 128) and IgG titers (> 1024). The donor plasma anti-A was IgG1, while the patient sera were an IgG3 and an IgG1 plus IgG2.

Conclusion
High anti-A IgM/IgG titers act synergistically to cause significant monocyte erythrophagocytosis by activating complement C3, thus engaging both Fcγ- and CR1-receptors.
Ultrafast dynamic contrast-enhanced breast MRI may generate prognostic imaging markers of breast cancer
Authors: Onishi Natsuko , Sadinski Meredith , Hughes Mary C. , Ko Eun Sook , Gibbs Peter , Gallagher Katherine M. , Fung Maggie M. , Hunt Theodore J. , Martinez Danny F. , Shukla-Dave Amita , Morris Elizabeth A. , Sutton Elizabeth J. 
Published: May 2020

Abstract
Background
Ultrafast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-derived kinetic parameters have demonstrated at least equivalent accuracy to standard DCE-MRI in differentiating malignant from benign breast lesions. However, it is unclear if they have any efficacy as prognostic imaging markers. The aim of this study was to investigate the relationship between ultrafast DCE-MRI-derived kinetic parameters and breast cancer characteristics.

Methods
Consecutive breast MRI examinations between February 2017 and January 2018 were retrospectively reviewed to determine those examinations that meet the following inclusion criteria: (1) BI-RADS 4–6 MRI performed on a 3T scanner with a 16-channel breast coil and (2) a hybrid clinical protocol with 15 phases of ultrafast DCE-MRI (temporal resolution of 2.7–4.6 s) followed by early and delayed phases of standard DCE-MRI. The study included 125 examinations with 142 biopsy-proven breast cancer lesions. Ultrafast DCE-MRI-derived kinetic parameters (maximum slope [MS] and bolus arrival time [BAT]) were calculated for the entire volume of each lesion. Comparisons of these parameters between different cancer characteristics were made using generalized estimating equations, accounting for the presence of multiple lesions per patient. All comparisons were exploratory and adjustment for multiple comparisons was not performed; P values < 0.05 were considered statistically significant.

Results
Significantly larger MS and shorter BAT were observed for invasive carcinoma than ductal carcinoma in situ (DCIS) (P < 0.001 and P = 0.008, respectively). Significantly shorter BAT was observed for invasive carcinomas with more aggressive characteristics than those with less aggressive characteristics: grade 3 vs. grades 1–2 (P = 0.025), invasive ductal carcinoma vs. invasive lobular carcinoma (P = 0.002), and triple negative or HER2 type vs. luminal type (P < 0.001).

Conclusions
Ultrafast DCE-MRI-derived parameters showed a strong relationship with some breast cancer characteristics, especially histopathology and molecular subtype.