bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for the adjuvant use of the poly-antibiotic–resistant probiotic Bacillus clausii (O/C, SIN, N/R, T) in acute, chronic, and antibiotic-associated diarrhea in children: consensus from Asian experts
Authors: De Castro Jo-Anne , Kesavelu Dhanasekhar , Lahiri Keya Rani , Chaijitraruch Nataruks , Chongsrisawat Voranush , Jog Pramod Prabhakar , Liaw Yun Haw , Nguyen Gia Khanh , Nguyen Thi Viet Ha , Pai Uday Ananth , Phan Huu Nguyet Diem , Quak Seng Hock , Tanpowpong Pornthep , Guno Mary Jean 
Published: October 2020

Abstract
This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Evidence-based recommendations and randomized controlled trials in the region are included. Cultural aspects, health management issues and economic factors were also considered. Final recommendations were approved by utilizing a modified Delphi process and applying the Likert scale in an electronic voting process. Bacillus clausii was recommended as an adjunct treatment with oral rehydration solution for acute viral diarrhea. B. clausii may also be considered for prevention of antibiotic-associated diarrhea, Clostridium difficile-induced diarrhea, and as adjunct treatment of Helicobacter pylori. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological, socioeconomical and health system conditions, similar recommendations currently apply to most Asia-Pacific countries. Ideally, these need to be validated with local randomized-controlled trials.
The Menopause Transition: Signs, Symptoms, and Management Options
Authors: Santoro Nanette , Roeca Cassandra , Peters Brandilyn A , Neal-Perry Genevieve 
Published: October 2020

Abstract

Context
Menopause, the permanent cessation of menses, reflects oocyte depletion and loss of gonadal steroids. It is preceded by a transition state, the perimenopause, which is characterized by the gradual loss of oocytes, altered responsiveness to gonadal steroid feedback, wide hormonal fluctuations, and irregular menstrual patterns. The goal of this mini-review is to discuss the basic pathophysiology of the menopausal transition and the hormonal and nonhormonal management of clinicopathology attributed to it.

Evidence Acquisition
A Medline search of epidemiologic, population-based studies, and studies of reproductive physiology was conducted. A total of 758 publications were screened.

Evidence Synthesis
The reproductive hormonal milieu of the menopausal transition precipitates bothersome vasomotor symptoms, mood disruption, temporary cognitive dysfunction, genitourinary symptoms, and other disease processes that reduce the quality of life of affected women. The endocrine tumult of the menopause transition also exposes racial and socioeconomic disparities in the onset, severity, and frequency of symptoms. Hormone therapy (HT) treatment can be effective for perimenopausal symptoms but its use has been stymied by concerns about health risks observed in postmenopausal HT users who are older than 60 and/or women who have been postmenopausal for greater than 10 years.

Conclusions
The menopause transition is a disruptive process that can last for over a decade and causes symptoms in a majority of women. It is important for clinicians to recognize early signs and symptoms of the transition and be prepared to offer treatment to mitigate these symptoms. Many safe and effective options, including HT, are available.
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53
Authors: Xu Xiuduan , Zhang Chongchong , Xu Huan , Wu Lin , Hu Meiru , Song Lun 
Published: October 2020

ABSTRACT
In our previous report, we demonstrated that one of the catalytic subunits of the IκB kinase (IKK) complex, IKKα (encoded by CHUK), performs an NF-κB-independent cytoprotective role in human hepatoma cells under the treatment of the anti-tumor therapeutic reagent arsenite. IKKα triggers its own degradation, as a feedback loop, by activating p53-dependent autophagy, and therefore contributes substantially to hepatoma cell apoptosis induced by arsenite. Interestingly, IKKα is unable to interact with p53 directly but plays a critical role in mediating p53 phosphorylation (at Ser15) by promoting CHK1 activation and CHK1–p53 complex formation. In the current study, we found that p53 acetylation (at Lys373 and/or Lys382) was also critical for the induction of autophagy and the autophagic degradation of IKKα during the arsenite response. Furthermore, IKKα was involved in p53 acetylation through interaction with the acetyltransferases for p53, p300 (also known as EP300) and CBP (also known as CREBBP) (collectively p300/CBP), inducing CHK1-dependent p300/CBP activation and promoting p300–p53 or CBP–p53 complex formation. Therefore, taken together with the previous report, we conclude that both IKKα- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy feedback degradation of IKKα during the arsenite-induced proapoptotic responses.
247. Los territorios digitales en el contexto del ciberespacio
Authors: Bernal Hidalgo Luis 
Published: October 2020

El ciberespacio se ha configurado hoy como un territorio digital que expande el contexto relacional y el entorno de información a partir del ejercicio de nuevas praxis culturales, que incluyen producir, intercambiar y controlar impresiones. Por lo anterior, se puede afirmar que es un proceso de construcción y de nuevas representaciones con las que se cincelan, sostienen y se transforman las posibilidades de aproximarse a la realidad, las formas de organización social y estructuración territorial. Este artículo hace un balance de los análisis presentados en las entrevistas realizadas en la tesis doctoral “La construcción del territorio a través del ciberespacio: una mirada latinoamericana de la percepción de los jóvenes frente al espacio virtual” sustentada en la Universidad de Valencia, España. Para mostrar como la evolución de las telecomunicaciones y el aumento de la interconectividad, ha potenciado la interacción social, con el surgimiento de prácticas cotidianas, identidades digitales, formas y procesos de cognición, símbolos, códigos y lenguajes, que han conformado nuevas relaciones sociales y novedosas culturas que se desarrollan en territorios marcados por la virtualidad.
Mowa przy pożegnaniu Wielebnych OO. Reformatów we Wronkach wygłoszona przez księdza Wincentego Kałkowskiego. Reprint źródła i komentarz
Authors: Tomczak Salezy Bogumił 
Published: October 2020

Klasztor we Wronkach należy do najstarszych fundacji zakonnych na terenie archidiecezji poznańskiej. Jego długą historię można podzielić na dwa okresy: dominikański i franciszkański. Okres dominikański rozpoczął się w 1279 a zakończył w 1835 roku, kiedy władze pruskie skasowały na swoim terenie zakony. Po kasacie groziła mu zamiana na cele świeckie a nawet całkowite zniszczenie. W 1854 roku powstał Komitet obywatelski, który postanowił ten pomnik wiary i polskości uratować. Ten cel udało się osiągnąć. W 1868 roku, po wykupieniu kościoła i klasztoru z rąk prywatnych, wspomniany Komitet obywatelski przekazał kościół do dyspozycji arcybiskupa gnieźnieńskiego i poznańskiego Mieczysława Halki Ledóchowskiego, ten zaś oddał go franciszkanom/reformatom. Franciszkanie pracowali przy nim zaledwie 7 lat. W 1875 roku władze pruskie zamknęły klasztor a zakonników usunęły. Publikujemy mowę, którą na pożegnanie franciszkanów wygłosił ks. Wincenty Kałkowski, wikariusz z Ostroroga, ze względu na zawartą w niej treść i wielką rzadkość tego druku. W 1924 roku franciszkanie wrócili do Wronek i w odzyskanym klasztorze urządzili niższe seminarium duchowne a w 1931 roku studium teologiczne. Od 1991 roku w klasztorze działa Wyższe Seminarium Duchowne Franciszkanów, które jest afiliowane do Wydziału Teologicznego Uniwersytetu im. Adama Mickiewicza w Poznaniu.
HISTORYK WE WSPÓŁCZESNYM ŚWIECIE. KILKA UWAG WOKÓŁ TEKSTU JANA POMORSKIEGO Polityzacja/mitologizacja historii, czyli w czym neuronauka (i metodologia) może pomóc badaczowi historii najnowszej?
Authors: STOBIECKI Rafał 
Published: October 2020

Regarding how the present historians get involved in the debate on the politicization of the contemporary history, we can observe a superannuation of two models of historian: as a „cool scientist” and an „upholder of national values”. Apparently we could postulate in this moment the model of a historian as “a translator and mediator” between cultures, recognizing their “grammars”, and his obligation to create the common social capital. Nevertheless the scientifi c refl ection upon the politicization of history and the methodology of contemporary historiography is the matt er in dispute. Th erefore Pomorski’s suggestion of the more complex cognitive approach in the historiographical research (and historical discourse) should be taken into consideration.
POLITYZACJA/MITOLOGIZACJA HISTORII, CZYLI W CZYM NEURONAUKA (I METODOLOGIA) MOŻE POMÓC BADACZOWI HISTORII NAJNOWSZEJ?
Authors: POMORSKI Jan 
Published: October 2020

The narratives created by historians with respect to events of the past serve not only the cognitive aims, but may also be used in the current discourse of power and as such be referred to as ‘historical politics’. In such cases the spotlight is no longer on the historical truth, but rather on the ability to legitimize the power exercised by one social group or political party over the rest of the society. The reason why one reaches for historical myth and politicizes historical narrative is that the emotions evoked in the process can access the mind of a common creator of history (homo historicus) much easier compared to historians’ refi ned analysis based on credible sources and proper methodology. From the perspective of historical politics, a historian – being a rational entity aware of its past (homo metahistoricus) – becomes something redundant, an obstacle that has to be silenced, suppressed or removed. All that matt ers is homo historicus, as it is the ballot in his or hers hand that will eventually determine winners and losers on election day. As is known, history writt en by the victors diff ers substantially from the one writt en by the defeated. Having diagnosed this way the situation relating to every historian aware of social responsibility of the results of historical studies, the author underlines that historical narrative may be applied to building both positive and negative social capital. Th e myth and politicization of history act toward dividing a community, rather than uniting it. Th ere is no way to create an eff ectively operating community without referring to past experiences, although when describing those experiences, it is very easy to fall into various traps of historical thinking. For this reason, neuroscience and methodology are of such a great importance to the historian of the 20th Century History.
Reality as a feeling – a feeling as reality. On the film by Joseph Cedar, Footnote
Authors: Hendrykowski Marek 
Published: October 2020

Hendrykowski Marek, Reality as a feeling – a feeling as reality. On the film by Joseph Cedar, Footnote. “Images” vol. XXV, no. 34. Poznań 2019. Adam Mickiewicz University Press. Pp. 57–xx. ISSN 1731-450X. DOI 10.14746/i.2019.34.04.
This analytical study by Marek Hendrykowski is an attempt to re-read one of the most valuable contemporary films of Israeli production, Footnote, written and directed by Joseph Cedar. The author paid particular attention to the specific way of conducting a seemingly dependent narration, skillfully combining the image of external reality with the sphere of thought and the feelings of the main character.
Terror films: The socio-cultural reconstruction of trauma in contemporary Israeli cinema
Authors: Ben-Moshe Yael , Ebbrecht-Hartmann Tobias 
Published: October 2020

Ben-Moshe Yael, Ebbrecht-Hartmann Tobias, Terror films: The socio-cultural reconstruction of trauma in contemporary Israeli cinema. “Images” vol. XXV, no. 34. Poznań 2019. Adam Mickiewicz University Press. Pp. 69–86. ISSN 1731-450X. DOI 10.14746/i.2019.34.05.
The public discourse in Israel regarding events such as the Holocaust, war, or terror attacks mostly failed to embrace the trauma caused by such events, and to integrate their effects in the collective memory. According to trauma theoreticians, the location of trauma in the discourse is related to the character of trauma as a non-narratable memory, since personal trauma exist in the void, thus marking a missing memory. This paper explores the notion of trauma in contemporary Israeli cinema as it was reconstructed during and after the Second Intifada (2000–2008). The paper focuses on feature films reflecting on experiences of terrorist violence, among them Avanim (2004), Distortion (2004), Frozen Days (2006), The Bubble (2006), 7 Minutes in Heaven (2009). These films embrace parallel elements structuring a worldview, in the private as well as the collective sphere, thus shaping the surroundings as a mirror of the self and the subjective traumatic experience as a reflection of a complex social reality.A particular focus of our analysis will also be on aesthetic strategies that cinematically express rupture and distortion of terrorist violence and trauma, especially moments of suddenness and disruption in contrast to duration and circular repetition, elements of a specific temporality of trauma that also shaped the narration and style of recent Israeli war films, such as Waltz with Bashir (2008) or Beaufort (2007).
Semiotics of Old Age in Polish Neo-Latin Poetry. Samboritanus, Cochanovius, Treter, Sarbievius, Ines
Authors: Buszewicz Elwira 
Published: October 2020

The main aim of this paper is to analyze several early-modern Neo-Latin poems written by Polish authors; the poems deal (in different ways) with old age. The poets undertake a kind of intertextual game with the reader, applying various stereotypes and clichés. On can speak about a “semiotic landscape” of old age. The authors taken into consideration are Jan Kochanowski, Grzegorz of Sambor, Thomas Treter (16th century) and Maciej Kazimierz Sarbiewski, Albert Ines (17th century).
Differential Short-Term Plasticity of PV and SST Neurons Accounts for Adaptation and Facilitation of Cortical Neurons to Auditory Tones
Authors: Seay Michael J. , Natan Ryan G. , Geffen Maria N. , Buonomano Dean V. 
Published: October 2020

Cortical responses to sensory stimuli are strongly modulated by temporal context. One of the best studied examples of such modulation is sensory adaptation. We first show that in response to repeated tones pyramidal (Pyr) neurons in male mouse auditory cortex (A1) exhibit facilitating and stable responses, in addition to adapting responses. To examine the potential mechanisms underlying these distinct temporal profiles, we developed a reduced spiking model of sensory cortical circuits that incorporated the signature short-term synaptic plasticity (STP) profiles of the inhibitory parvalbumin (PV) and somatostatin (SST) interneurons. The model accounted for all three temporal response profiles as the result of dynamic changes in excitatory/inhibitory balance produced by STP, primarily through shifts in the relative latency of Pyr and inhibitory neurons. Transition between the three response profiles was possible by changing the strength of the inhibitory PV→Pyr and SST→Pyr synapses. The model predicted that a unit's latency would be related to its temporal profile. Consistent with this prediction, the latency of stable units was significantly shorter than that of adapting and facilitating units. Furthermore, because of the history-dependence of STP the model generated a paradoxical prediction: that inactivation of inhibitory neurons during one tone would decrease the response of A1 neurons to a subsequent tone. Indeed, we observed that optogenetic inactivation of PV neurons during one tone counterintuitively decreased the spiking of Pyr neurons to a subsequent tone 400 ms later. These results provide evidence that STP is critical to temporal context-dependent responses in the sensory cortex.SIGNIFICANCE STATEMENTOur perception of speech and music depends strongly on temporal context, i.e., the significance of a stimulus depends on the preceding stimuli. Complementary neural mechanisms are needed to sometimes ignore repetitive stimuli (e.g., the tic of a clock) or detect meaningful repetition (e.g., consecutive tones in Morse code). We modeled a neural circuit that accounts for diverse experimentally-observed response profiles in auditory cortex (A1) neurons, based on known forms of short-term synaptic plasticity (STP). Whether the simulated circuit reduced, maintained, or enhanced its response to repeated tones depended on the relative dominance of two different types of inhibitory cells. The model made novel predictions that were experimentally validated. Results define an important role for STP in temporal context-dependent perception.
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System
Authors: Rijo-Ferreira Filipa , Bjorness Theresa E. , Cox Kimberly H. , Sonneborn Alex , Greene Robert W. , Takahashi Joseph S. 
Published: October 2020

Patients with sleeping sickness, caused by the parasiteTrypanosoma brucei, have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed the sleep architecture of male mice infected withT. bruceiand found that infected mice had drastically altered sleep patterns. Interestingly,T. brucei-infected mice also had a reduced homeostatic sleep response to sleep deprivation, a response modulated by the adenosine system. We found that infected mice had a reduced electrophysiological response to an adenosine receptor antagonist and increased adenosine receptor gene expression. Although the mechanism by whichT. bruceiinfection causes these changes remains to be determined, our findings suggest that the symptoms of sleeping sickness may be because of alterations in homeostatic adenosine signaling.SIGNIFICANCE STATEMENTSleeping sickness is a fatal disease that disrupts the circadian clock, causes disordered temperature regulation, and induces sleep disturbance. To examine the neurologic effects of infection in the absence of other symptoms, in this study, we used a mouse model of sleeping sickness in which the acute infection was treated but brain infection remained. Using this model, we evaluated the effects of the sleeping sickness parasite,Trypanosoma brucei, on sleep patterns in mice, under both normal and sleep-deprived conditions. Our findings suggest that signaling of adenosine, a neuromodulator involved in mediating homeostatic sleep drive, may be reduced in infected mice.
Prebirth Household Challenges To Predict Adverse Childhood Experiences Score by Age 3
Authors: Rittman Danielle , Parrish Jared , Lanier Paul 
Published: October 2020

OBJECTIVES:
With this study, we seek to understand the relationship between prebirth household challenges and the child’s adverse childhood experiences (ACEs) score by age 3 in a statewide-representative birth cohort to inform primary prevention strategies.

METHODS:
We used a longitudinally linked data set from the Alaska 2009–2011 Pregnancy Risk Assessment Monitoring System, its 3-year follow-up survey, and multiple administrative data sources. Using this linked data set, we predicted an expanded ACEs score by age 3 using maternal reported prebirth household challenges.

RESULTS:
The number of household challenges reported during the 12 months before or during pregnancy predicted ACEs score in a graded, dose-response manner. On average, reporting 4+ prebirth household challenges was associated with an ACEs score 4.1 times that of those reporting 0 challenges. Homelessness was associated with the greatest increase in ACEs score (relative rate ratio = 3.0). Prebirth household challenges that were independently associated with an elevated ACEs score in our final model included problems paying bills, someone close to the mother having a drinking and/or drug problem, homelessness, mother or husband or partner being in jail, husband or partner losing job, separation or divorce, and being checked or treated for anxiety or depression.

CONCLUSIONS:
The accumulation and certain prebirth household challenges are strongly associated with the accumulation of childhood ACEs. Addressing and reducing household challenges during the prebirth period may serve as a primary point of ACEs prevention. Many evidence-based, multidisciplinary intervention strategies can and should be implemented in the prebirth period to strengthen the household unit before the introduction of a new child.
Urban streams in Latin America: Current conditions and research needs
Authors: Walteros Jeymmy M. , Ramírez Alonso 
Published: October 2020

Introduction: Latin America is a highly urbanized region, with most of its population living in cities and urban centers. While information about urban streams in Latin America is rather limited, streams are expected to experience similar environmental impacts and conservation issues as urban streams in parts of the globe, including habitat loss, channelization, sewage discharge, trash, and loss of riparian habitats. Objective: We surveyed a network of researchers from approximately 80% of the countries in Latin America to obtain information on the condition, state of knowledge, and threats to urban streams in the region. Methods: Most participants were reached via the Macrolatinos@ network (www.macrolatinos.net). Results: We obtained 104 responses from researchers in 18 of the 23 Latin American countries. Most urban streams are impacted or degraded, and inputs of contaminants and wastewater discharges were considered major drivers of stream degradation. Most respondents indicated that stream channelization is common, with some streams completely channelized or buried. Sewage and rainfall runoff management were identified as a major factor degrading streams, with most respondents suggesting that streams are a primary destination for wastewater discharge, much of which is untreated. Major limitations to urban stream conservation in Latin America are the result of limited ecological knowledge, lack of citizen interest or political will to protect them. There are isolated efforts to restore urban streams and riparian zones, but these are initial steps that need further development. Conclusions: Our research network of Latin American scientists proved to be a valuable tool to assess a large number of urban rivers in a relatively understudied region. Urban streams in Latin America face a diversity of stressors and management challenges, and we propose three areas that would benefit from further research to improve our understanding and management of these systems: (1) Studies should focus on the watershed, rather than isolated reaches, (2) researchers should strive to attain a better understanding of ecosystem function and the services provided by urban streams to justify management and restoration efforts, and (3) studies that integrate economic models where downstream users pay for upstream protection and restoration could prove beneficial for many Latin American cities in attempting to address water conservation issues.