bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abiraterone acetate (AA) with or without cabazitaxel (CBZ) in treatment of chemotherapy naive metastatic castration-resistant prostate cancer (mCRPC).
Authors: Slovin Susan F. , Knudsen Karen E. , Halabi Susan , Fleming Mark T. , Molina Ana M. , Wolf Steven Paul , de Leeuw Renee , Fernandez Celina , Kang Praneet , Southwell Traci , Jones Carol L. , Fernandez Escarleth , Kelly William Kevin 
Published: February 2020

84 Background: Loss of retinoblastoma tumor suppressor (RB) function has been shown to lead to CRPC and is strongly associated with poor outcome. RB functions as a transcriptional repressor; as such, loss of RB causes de-repression of pro-tumorigenic gene networks, including deregulation of the androgen receptor (AR) locus, excessive AR production, and castration-resistant (ligand independent) AR activity that can bypass hormone therapy. Our hypothesis is that leveraging RB status can direct treatment decisions. The primary objective of the trial (NCT02218606) was to determine the radiographic progression free survival (rPFS) of AA/prednisone (AAP) with and without CBZ in mCRPC patients (pts) that have progressed on primary androgen deprivation therapy and no prior AR directed therapy or chemotherapy. Methods: This is a multicenter non-comparative randomized phase 2 trial. Pts were randomized 1:1 to AAP with crossover to CBZ upon AAP failure (Arm 1), or the combination of AAP + CBZ (Arm 2). Randomization was stratified by the CALGB 90401 prognostic risk groups. The primary endpoint was rPFS (time from randomization to radiographic progression or death, whichever occurs first). Arms were analyzed separately. Results: Between October 2014 and March 2019, 93 pts were accrued; 81 were randomized. Median age was 68 years and ECOG performance status was 0 or 1. Endpoints are shown in Table. Therapies were well tolerated. Conclusions: Results of AAP + CBZ (Arm 2) in chemotherapy naïve pts suggest that men may derive benefit from the earlier use of CBZ with acceptable toxicity, supporting further study of this combination in mCRPC pts. Circulating Tumor Cells are being analyzed for changes in RB/AR expression. Managed by: Prostate Cancer Clinical Trials Consortium; Funding: Sanofi US; Support: Prostate Cancer Foundation. Clinical trial information: NCT02218606. [Table: see text]
Prostate oncologic therapy while ensuring neurovascular conservation (POTEN-C): A phase II randomized controlled trial of stereotactic ablative body radiotherapy (SAbR) with or without neurovascular sparing for erectile function preservation in localized prostate cancer.
Authors: Desai Neil Bipinchandra , Folkert Michael Ryan , Leiker Andrew , Yan Yulong , Costa Daniel N. , Dess Robert Timothy , Spratt Daniel Eidelberg , Garant Aurelie , Hannan Raquibul , Timmerman Robert D. 
Published: February 2020

TPS381 Background: Radiotherapy (RT) associated sexual dysfunction occurs in half of men following treatment for localized prostate cancer. Proposed mechanisms include vascular injury of adjacent internal pudendal arteries (IPA), penile bulb (PB), corpora cavernosa (CC) or neurovascular bundles (NVB). Ability to spare these structures has been limited by a presumed need to treat the entire prostate gland, while also preventing rectal injury. Recent innovations have challenged this issue: a) precise dose delivery with stereotactic ablative RT (SAbR), b) improved spatial mapping of clinically significant disease with mpMRI, c) rectal avoidance with rectal spacer use. Methods: POTEN-C is a multi-center phase II randomized control trial, which includes men with a) low-intermediate risk prostate cancer eligible for SAbR without ADT, b) potent by sexual composite score ≥60 on EPIC patient-reported quality of life instrument, c) mpMRI delineated disease (PIRADS v2 score 3-5) ≥5mm to at least one ‘spared’ NVB. After placement of rectal spacer gel and CT/MRI simulation, men are randomized to standard SAbR to 40-45Gy/5fx or neurovascular-sparing SAbR. In the sparing experimental arm, the prostate PTV is given 30Gy/5fx excluding unilateral ‘spared’ NVB, while a 40-45Gy PTV further excludes a 5mm protective shell on the unilateral ‘spared’ NVB+IPA+PB+CC. Centralized rapid review of initial contours/plans and online training materials are integrated. The primary endpoint is 2-year patient-reported potency, measured by EPIC sexual composite score. We hypothesize that neurovascular sparing SAbR will reduce 2-year EPIC score decline from a control of 20 to 10 (corresponding to a MCID). Assuming standard deviation 20, two-sided significance level 0.10 with two-sample t-testing, and 15% attrition, we intend to enroll 120 patients to provide 80% power to detect this difference. Secondary endpoints include sexual medication/aid use, relapse rates, GU/GI toxicity. Enrollment is ongoing. Details: http://www.poten-c.org . Clinical trial information: 03525262.
Phase III study of first-line pembrolizumab (pembro) plus lenvatinib (len) in patients (pts) with advanced urothelial carcinoma (UC) ineligible for platinum-based chemotherapy: LEAP-011.
Authors: Loriot Yohann , Balar Arjun Vasant , De Wit Ronald , Garcia Jorge A. , Grivas Petros , Matsubara Nobuaki , Homet Moreno Blanca , Sbar Eric , Jia Xieyang Calvin , Dutcus Corina E. , Siefker-Radtke Arlene O. 
Published: February 2020

TPS597 Background: KEYNOTE-052 (NCT02335424) results led to pembro, a PD-1 inhibitor, to become the standard of care for cisplatin-ineligible pts with locally advanced or metastatic UC with tumors expressing PD-L1 and for pts unable to receive platinum-based chemotherapy regardless of PD-L1 status. Len, a potent, multiple-receptor, tyrosine kinase inhibitor has activity in multiple solid tumors. KEYNOTE-146 (NCT02501096) results showed promising efficacy and manageable safety with pembro+len in previously treated pts with advanced UC, regardless of PD-L1 status. Methods: LEAP-011 (NCT03898180) is a randomized phase 3 study to assess efficacy and safety of pembro+len, compared with pembro+placebo, in pts with advanced UC. An estimated 694 pts will be enrolled. Adults (≥18 years) with histologically confirmed locally advanced unresectable or metastatic UC who are either cisplatin-ineligible with tumors expressing PD-L1 (combined positive score [CPS] ≥10) or ineligible to receive any platinum-based chemotherapy are eligible. Pts are required to have an ECOG PS of 0-2 and provide tumor tissue for PD-L1 analysis. Previous treatment with systemic chemotherapy for advanced UC is not permitted, except in cases of recurrence after 1 year of platinum-based chemotherapy for either muscle-invasive bladder cancer (neoadjuvant) or after radical cystectomy (adjuvant). Pts will be randomly assigned 1:1 to receive pembro 200 mg IV every 3 weeks for up to 35 cycles (~2 y) plus either len 20 mg or placebo orally once daily. Pts will be stratified as follows: ineligible for any platinum containing chemotherapy and ECOG PS 2 (CPS ≥10 vs <10); cisplatin ineligibility and CPS ≥10 (ECOG 0-1 vs 2). Radiologic assessment will include CT/MRI of the chest, abdomen, and pelvis, and bone imaging. Responses will be assessed per RECIST v1.1 by blinded independent central review (BICR). Coprimary end points are PFS and OS. Secondary end points are objective response rate, duration of response, and disease control rate per RECIST v1.1 by BICR; patient-reported outcomes; and safety. Tissue-and blood-based biomarkers will be explored. Accrual began May 6, 2019. Clinical trial information: NCT03898180.
A phase Ib study targeting PIM1 and CDK4/6 kinases in metastatic renal cell carcinoma (PICKRCC).
Authors: Holder Sheldon L. , Warrick Joshua , Zhu Junjia , Drabick Joseph J. , Joshi Monika 
Published: February 2020

TPS771 Background: Over the last few years there has been a rapid increase in the clinically relevant agents available to treat metastatic renal cell carcinoma (mRCC). We note, however, that the vast majority of new agents available for mRCC do not exploit new clinical targets or pathways. We believe that the identification of new, clinically relevant targets in RCC will propel the field even further forward, expand treatment options, and lead to improved survival for mRCC patients. SGI-1776, a selective PIM1 kinase inhibitor, has previously been shown to induce reduction in tumor size as monotherapy and in combination with sunitinib in mouse pre-clinical studies of RCC. In our tissue microarray studies a subset of ~26% of RCC showed high staining for PIM1 kinase while only 1% of normal adjacent tissue showed similar high staining. Wildtype PIM1 is constitutively active, thus these data suggest that PIM1 activity is increased in a subset of RCC. Abemaciclib is a potent CDK4/6 inhibitor with an IC50 of 2 and 10 nM, respectively. It is also a potent PIM1 inhibitor with an IC50 of 50 nM. We have shown that abemaciclib decreases cell viability and increases apoptosis in RCC cell lines, and does so at greatest effect in combination with sunitinib. We have also shown that abemaciclib induces regression of RCC tumors in a mouse model of RCC, with the most rapid responses observed when abemaciclib is combined with sunitinib. Based on these data we have opened a phase Ib dose escalation study to determine the safety and tolerability of abemaciclib in combination with sunitinib in patients with mRCC. The study includes an expansion cohort at the recommended phase II dose to evaluate for a signal for efficacy. Pattern and intensity of PIM1 staining in tumor tissue will be evaluated as a potential biomarker of response. We are also collecting blood and urine to evaluate additional potential biomarkers of response. Methods: Clinical trial information: NCT03905889 .[Table: see text]
Performance Measures Based on How Adults With Cancer Feel and Function: Stakeholder Recommendations and Feasibility Testing in Six Cancer Centers
Authors: Stover Angela M. , Urick Benjamin Y. , Deal Allison M. , Teal Randall , Vu Maihan B. , Carda-Auten Jessica , Jansen Jennifer , Chung Arlene E. , Bennett Antonia V. , Chiang Anne , Cleeland Charles , Deutsch Yehuda , Tai Edmund , Zylla Dylan , Williams Loretta A. , Pitzen Collette , Snyder Claire , Reeve Bryce , Smith Tenbroeck , McNiff Kristen , Cella David , Neuss Michael N. , Miller Robert , Atkinson Thomas M. , Spears Patricia A. , Smith Mary Lou , Geoghegan Cindy , Basch Ethan M. 
Published: February 2020

PURPOSE: Patient-reported outcome measures (PROMs) that assess how patients feel and function have potential for evaluating quality of care. Stakeholder recommendations for PRO-based performance measures (PMs) were elicited, and feasibility testing was conducted at six cancer centers. METHODS: Interviews were conducted with 124 stakeholders to determine priority symptoms and risk adjustment variables for PRO-PMs and perceived acceptability. Stakeholders included patients and advocates, caregivers, clinicians, administrators, and thought leaders. Feasibility testing was conducted in six cancer centers. Patients completed PROMs at home 5-15 days into a chemotherapy cycle. Feasibility was operationalized as ≥ 75% completed PROMs and ≥ 75% patient acceptability. RESULTS: Stakeholder priority PRO-PMs for systemic therapy were GI symptoms (diarrhea, constipation, nausea, vomiting), depression/anxiety, pain, insomnia, fatigue, dyspnea, physical function, and neuropathy. Recommended risk adjusters included demographics, insurance type, cancer type, comorbidities, emetic risk, and difficulty paying bills. In feasibility testing, 653 patients enrolled (approximately 110 per site), and 607 (93%) completed PROMs, which indicated high feasibility for home collection. The majority of patients (470 of 607; 77%) completed PROMs without a reminder call, and 137 (23%) of 607 completed them after a reminder call. Most patients (72%) completed PROMs through web, 17% paper, or 2% interactive voice response (automated call that verbally asked patient questions). For acceptability, > 95% of patients found PROM items to be easy to understand and complete. CONCLUSION: Clinicians, patients, and other stakeholders agree that PMs that are based on how patients feel and function would be an important addition to quality measurement. This study also shows that PRO-PMs can be feasibly captured at home during systemic therapy and are acceptable to patients. PRO-PMs may add value to the portfolio of PMs as oncology transitions from fee-for-service payment models to performance-based care that emphasizes outcome measures.
Correlated charge form factors and densities of the sd-shell nuclei
Authors: Massen S. E. 
Published: February 2020

The expression of the two body term in the fac­ tor cluster expansion of the charge form factor of 40Ca is derived.lt contains the harmonic oscillator (HO) parameter bx and the parameter λ which originates from the Jastrow correlation function. This expression together with the corresponding one of 16O nucleus helps to find a mass de­pendence of λ and an approximate and fairly simple expres­ sion of the two body term of open shell nuclei in the region 16<A<40 which contains one free parameter, the HO parameter bi. The fitting to the corresponding experimen­tal charge form factor is quite improved in comparison to the HO one without correlations.
Is intracellular Staphylococcus aureus associated with recurrent infection in a rat model of open fracture?
Authors: Gao Tao , Lin Junqing , Zhang Changqing , Zhu Hongyi , Zheng Xianyou 
Published: February 2020

Aims The purpose of this study was to determine whether intracellular Staphylococcus aureus is associated with recurrent infection in a rat model of open fracture. Methods After stabilizing with Kirschner wire, we created a midshaft femur fracture in Sprague-Dawley rats and infected the wound with green fluorescent protein (GFP)-tagged S. aureus. After repeated debridement and negative swab culture was achieved, the isolation of GFP-containing cells from skin, bone marrow, and muscle was then performed. The composition and viability of intracellular S. aureus in isolated GFP-positive cells was assessed. We suppressed the host immune system and observed whether recurrent infection would occur. Finally, rats were assigned to one of six treatment groups (a combination of antibiotic treatment and implant removal/retention). The proportion of successful eradication was determined. Results Green fluorescent protein-containing cells were successfully isolated after the swab culture was negative from skin (n = 0, 0%), muscle (n = 10, 100%), and bone marrow (n = 10, 100%) of a total of ten rats. The phagocytes were predominant in GFP-positive cells from muscle (73%) and bone marrow (81%) with a significantly higher viability of intracellular S. aureus (all p-values < 0.001). The recurrent infection occurred in up to 75% of rats after the immunosuppression. The proportion of successful eradication was not associated with implant retention or removal, and the efficacy of linezolid in eradicating intracellular S. aureus is significantly higher than that of vancomycin. Conclusion Intracellular S. aureus is associated with recurrent infection in the rat model of open fracture. Usage of linezolid, a membrane-permeable antibiotic, is an effective strategy against intracellular S. aureus. Cite this article: Bone Joint Res. 2020;9(2):71–76.
Crossing the European boundary: The conjoined figures of colonizer and migrant in Zama (Martel, 2017) and The Other Side of Hope (Kaurismäki, 2017)
Authors: Taşkale Ali Rıza , Şima Erdoğan H. 
Published: February 2020

Abstract
Caught between the seemingly contradictory imageries of particularity and universality, 'European identity' could in fact be presumed but as a shorthand for ontological anxiety. The ('euro-') centric ontology that it denotes is marked by an ongoing ambivalence that both recoils from and accepts the superfluousness of boundaries. The obverse of this ambivalent concern with boundaries, we suggest, are the narrative efforts to consign it to the singular agency of the 'impossible' boundary crossing. Cinematographically speaking, the otherwise mute ontological anxiety is contained in the precariousness of the figures of colonizer and migrant. The way a 'European' cinema relates to these figures becomes all the more significant where 'Europe' denotes a challenging relationship, and not a 'thing'. It is in view of the ways in which they respond to this challenge that we examine Zama (Martel, 2017) and The Other Side of Hope (Kaurismäki, 2017). The focus, in other words, is on what nevertheless escapes their efforts: while Zama's out-of-place 'colonizer' obscures the inherent placelessness of colonial agency, Hope's symbiotic relationship between the self and the other withholds the reversibility of the 'self/other' dualism. In the instrumental visibility of their singular figures, we hope to show, both films contribute to the incidental visibility of the 'European' claim to transcend its own dualisms. The figures of colonizer and migrant are in fact the relatively visible symptoms of a cinematic labour whose ambivalences remain otherwise invisible.
Europe, spectrality and 'post-mortem cinema': The haunting of history in Christian Petzold's Transit (2018) and Aki Kaurismäki's Le Havre (2011)
Authors: Bardan Alice 
Published: February 2020

Abstract
This article considers the ways in which contemporary filmmakers such as and ) experiment with narrative and stylistic strategies to tell their own story about a haunted Europe caught, yet again, in a paranoid policing of borders, and marked by an increasingly tense political climate that gave rise to nationalistic anxieties and exclusionary practices. Drawing on , and on Érik Bullot's and Thomas Elsaesser's concept of 'post-mortem' cinema, I argue that by blurring time frames and by allowing the future to coexist with past and present, films such as Transit and Le Havre give a new twist to the problematic of negotiating Europe's past. Deploying the trope of haunting, both films mobilize a critical attitude towards the complacency of our own times, alerting viewers to the imagined futures and dreams of various figures from the past and to their capacity to conceive of a world radically different from the one in which we currently live.
On Quentin Meillassoux and the Problem of Evil
Authors: Mangion Claude 
Published: February 2020

AbstractThe problem of evil and the injustice it brings out has a long history in western philosophy and it has been one of the core arguments against the existence of God as an all-powerful and all-good Being. In a number of texts Meillassoux agrees with this line of argument, but he also argues that atheism fails to take into account the injustice of evil. His central thesis is that while the existence of evil discounts the existence of the ‘revealed’ God, he proposes a messianic vision where we can hope for the arrival of a God who will have the power to rectify the injustices that have been committed. To justify the possible arrival of such a being Meillassoux describes the world as a contingent place such that things happen without a necessary reason. This explains why, in the past, novel and inexplicable situations (‘advents’) have arisen and, possibly, others might arise. One such possibility is the arrival of a God who will redeem all the injustices suffered within the world.
Learning to be human with sociable robots
Authors: Weiss Dennis M. 
Published: February 2020

AbstractThis essay examines the debate over the status of sociable robots and relational artifacts through the prism of our relationship to television. In their work on human-technology relations, Cynthia Breazeal and Sherry Turkle have staked out starkly different assessments. Breazeal’s work on sociable robots suggests that these technological artifacts will be human helpmates and sociable companions. Sherry Turkle argues that such relational artifacts seduce us into simulated relationships with technological others that largely serve to exploit our emotional vulnerabilities and undermine authentic human relationships. Drawing on an analysis of the television as our first relational artifact and on the AMC television show Humans, this essay argues that in order to intervene in this debate we need a multimediated theory of technology that situates our technical artifacts in the domestic realm and examines their impact on those populations especially impacted by such technologies, including women, children, and the elderly. It is only then that we will be able to take the full measure of the impact of such sociable technologies on our being human.
Una introducción a la teoría de la Metalengua Semántica Natural (NSM) y su aplicación a la pragmática
Authors: Fernández Susana S. 
Published: February 2020

ResumenEste artículo expone los principios de la teoría de la Metalengua Semántica Natural (NSM por sus siglas en inglés), originalmente propuesta por Wierzbicka (1972.Semantic primitives. Frankfurt: Athenaeum) y luego desarrollada en una serie de trabajos por Anna Wierzbicka y Cliff Goddard, además de otros académicos que trabajan en el campo. El objetivo es presentar cómo esta teoría se ha aplicado al estudio de la semántica y de la pragmática para analizar distintos aspectos de los hábitos lingüísticos de un determinado grupo cultural sin recurrir a modelos de universalidad, sino más bien trabajando desde dentro de la lengua estudiada para reconocer conceptos claves y estilos comunicativos que le son propios. El artículo presenta los conceptos deexplicaciones semánticasyguiones culturales, que son explicaciones redactadas con la metodología deparáfrasis reductoraa través de la herramienta de la NSM. La NSM es un minilengua compuesta por una serie de conceptos muy básicos y traducibles a todas las lenguas que sirven como punto de partida para explicar conceptos más complejos. Esta teoría ha sido complementada por Cliff Goddard con el concepto delengua mínima, que también se presentará en el artículo. El artículo concluye con una exposición de las similitudes y diferencias que existen entre esta forma de hacer pragmática intercultural y la propuesta por otras teorías de la pragmática, incluida la teoría de la Pragmática Sociocultural de Diana Bravo y sus colegas.
A importância da alfabetização cartográfica no ensino-aprendizagem da Geografia
Authors: Siqueira Rafaela Silva de , Santos Fernanda Rayane Tavares dos , Feitosa Ailton 
Published: February 2020

RESUMO: O presente artigo tem como objetivo, apresentar a organização das atividades desenvolvidas no Programa Institucional de Bolsa e Iniciação à Docência (PIBID), da Universidade Estadual de Alagoas (UNEAL) durante o período de 2018 a 2019, na escola Estadual Monsenhor Macedo, na turma da 3ª série do Ensino Médio no âmbito da Cartografia. Sempre há o interesse em provocar o pensamento crítico nos alunos a respeito do ensino fornecido e aplicado em sala de aula, principalmente no que se refere ao uso de mapas nas aulas de Geografia. Isto, porquê, ressalta-se a importância dessa linguagem, para que o sujeito compreenda com mais significado a construção, organização e reconstrução do espaço geográfico. Nesse sentido, o principal objetivo do projeto foi fazer com que o aluno compreendesse os fatores da base cartográfica trabalhando com as informações dos conteúdos apresentados e discutidos na Geografia em sala de aula. A partir da imaginação, leitura e construção de mapas é possível associar o mundo real, com sua representação na Cartografia produzida no material didático e, até mesmo subtrair dela outras formas de interpretação. Assim, o trabalho partiu da deficiência apresentada por grande parte dos alunos que chegam das séries inicias do Ensino Fundamental ao Ensino Médio, sem compreender o verdadeiro significado das informações geográficas em relação ao ensino-aprendizagem da cartografia na sala de aula. Destaca-se nas observações colhidas neste trabalho, como referências à parte das oficinas, autores como ALMEIDA (2011) e SIMIELLI (1991), além do professor Dr. Ailton Feitosa, em atividades lúdicas que não estão inseridas na rotina escolar, trazendo ao centro de seus conhecimentos o que a monotonia do livro didático costuma esconder.
PALAVRAS-CHAVE: Cartografia, PIBID, Ensino, Geografia.