bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient health care 30 days after hospitalization for heart failure in France
Authors: Lesuffleur T , Feldman S , Tuppin P , Constantinou P , Olié V , Jullière Y 
Published: November 2019

Abstract

Background
Recommendations for heart failure (HF) outpatient follow-up have been published. The SNDS offers the opportunity to confront them to real-life, including geographical disparities. Moreover, estimation variation has to be explored when population excludes institutionalized patients (IP) that have specific healthcare use and refund: rehabilitation (SSR), psychiatric hospitalization (psy), skilled nursing home (EHPAD) which is not usually done.The Purpose is to study outpatient healthcare use variations in France after hospitalization for HF, using SNDS data.

Methods
The first stay for HF (&gt;0days) in 2015 of patients over 18 yo covered by the general scheme (RG/SLM 88% of population) was considered. Healthcare use 30 days after was compared with (RG/SLM) or without IP (RG/SLM eIP). Regional outpatient care use rates were standardized by age and sex.

Results
Among 104 984 alive patients 30 days after HF hospitalization (RG/SLM, female 52%, mean age 79 yo), 16% stayed in SSR, 9% in cardiologic SSR, 12% in EHPAD, 0.2% in psy and 75% returning home and not institutionalized (RG/SLM eIP; n = 70367). Among all RG/SLM patients vs RG/SLM eIP (mean age 79 yo vs 78 yo), a cardiologist was seen at least once in 30 days post hospitalization 20% vs 21% (median delay 14 days IQR 7-23 vs 16 IQR 9-24), a general practitioner 69% vs 78% (8 IQR 3-16 vs 7 IQR 3-15), a nurse 58% vs 69% (3 IQR 1-9 vs 2 IQR 1-7). ACE inhibitors were reimbursed at least once for 34% vs 39%, ARBs 14% vs 17%, and diuretics 69% vs 77%. Among RG/SLM eIP patients, departmental disparities were high: cardiologist (3% to 46%), GP (59% to 93%), nurse visit (49% to 82%). Lower rates for GP were found in the center of France but with higher rates for nurse visits.

Conclusions
We recommend using RG/SLM eIP when studying outpatient healthcare use in the SNDS. Low visit rates and high delays regarding the recommendations point out the need of a multidisciplinary community health care in France.

Key messages
Low visit rates and high delays regarding the recommendations point out the need of a multidisciplinary community health care in France. We recommend using RG/SLM eIP when studying outpatient healthcare use in the SNDS.
Significant improvement in cancer management in Europe
Authors: Jelenc M , Albreht T 
Published: November 2019

Abstract

Background
Cancer management represents one of the most complex disease management segments in health care. Quality National Cancer Control Programmes (NCCPs) play the key role in cancer management in responding to population needs by preventing, detecting and treating cancer only through adequate planning. An effective NCCP represents benefits for patients, citizens, health care providers, health systems and governments. Europe is still characterised by inequalities in cancer control both between and within countries. In response to this challenge, a generic list of evidence-based tools for efficient stewardship and measure of effects of the cancer control will be prepared.

Methods
A survey on the current state of NCCPs in EU Member States, EEA countries and EU candidate countries and on the presence of some key elements, which NCCPs should include, was conducted in 2018 in the frame of the Joint Action (JA) Innovative Partnership for Action Against Cancer (iPAAC). The completed surveys were analysed; the answers were compared with the report prepared on the basis of the survey carried out in 2011 in the frame of JA EPAAC.

Results
In total, 33 out of 34 EU Member States, some EEA countries and EU candidate countries completed the survey, the response rate was 97%. Thirty-one out of 33 countries reported that they have a NCCP or another relevant cancer document. Belgium does not have a NCCP, Croatia and Serbia prepared draft versions. The inclusion of patient pathways, quality indicators as well as PROMS in NCCPs is not satisfactory. Only 10 countries included PROMS in their NCCP.

Conclusions
On the basis of the preliminary results of the survey we conluded that the situation regarding NCCPs in Europe improved in comparison with the situation in 2011. EU countries have mostly adopted a NCCP, plan or strategy as a single or several documents. We aim at developing practical instructions for the successful governance and steering of cancer care in all EU Member States.

Key messages
The development of NCCPs represents added value for cancer patients in all EU Member States. The inclusion of patient pathways, quality indicators as well as patient reported outcome measures (PROMS) in NCCPs/cancer documents is not satisfactory.
Attitudes and behaviours of theology faculty students on organ donation An Eastern City Of Turkey
Authors: Tekin C , Gokce A , Ozer A 
Published: November 2019

Abstract

Background
Transplantation is the process by which a solid tissue or organ from a living donor or cadaver is transplanted to replace an organ that cannot function properly in the body. Religious beliefs of individuals affect their attitudes and behaviours regarding organ donation. The aim of the study is to determine the knowledge, attitudes, behaviours of Theology Faculty students about organ donation.

Methods
The study is cross-sectional study which carried out on students in Faculty of Theology.Total number of students was 800 at the time of study. Sample selection was not performed in this study,70% of the population was included. The first part of the questionnaires, which we created as data collection tools, comprised socio-demographic questions, whereas the second part comprised questions, prepared according to the literature that measures the knowledge, attitudes and behaviours on organ donation. Chi-square test was used for statistical analysis.

Results
0.7% Of the students participating in the study stated that they were organ donors, whereas 56.4% said that they considered organ donation as religiously appropriate behaviour, and 38.6% said that they have not become organ donors before because the subject of organ donation was not brought to their attention previously. A comparison of whether the students viewed organ donation as religiously appropriate behaviour with the students’ level of knowledge on organ donation revealed to be 65.8% among students with knowledge on organ donation and 49.5% among students who lacked knowledge on organ donation(p &lt; 0.05).

Conclusions
The ratio of organ donors among the participants was 0.7%. Students with knowledge on organ donation also said that they viewed organ donation as religiously appropriate behaviour. Through training activities, the aim should be to increase the level of knowledge and awareness on organ donation of future religious staff and to thereby increase the level of organ donation in the society.

Key messages
The ratio of organ donation among Theology Faculty students is low. The subject of organ donation should be added to the curriculum of Theology Faculty students.
Cultivation-assisted genome of Candidatus Fukatsuia symbiotica; the enigmatic ‘X-type’ symbiont of aphids
Authors: Patel V , Chevignon G , Manzano-Marín A , Brandt J W , Strand M R , Russell J A , Oliver K M 
Published: November 2019

Abstract
Heritable symbionts are common in terrestrial arthropods and often provide beneficial services to hosts. Unlike obligate, nutritional symbionts that largely persist under strict host control within specialized host cells, heritable facultative symbionts exhibit large variation in within-host lifestyles and services rendered with many retaining the capacity to transition among roles. One enigmatic symbiont, Candidatus Fukatsuia symbiotica, frequently infects aphids with reported roles ranging from pathogen, defensive symbiont, mutualism exploiter and nutritional co-obligate symbiont. Here we used an in vitro culture-assisted protocol to sequence the genome of a facultative strain of Fukatsuia from pea aphids (Acyrthosiphon pisum). Phylogenetic and genomic comparisons indicate that Fukatsuia is an aerobic heterotroph, which together with Regiella insecticola and Hamiltonella defensa form a clade of heritable facultative symbionts within the Yersiniaceae (Enterobacteriales). These three heritable facultative symbionts largely share overlapping inventories of genes associated with housekeeping functions, metabolism, and nutrient acquisition, while varying in complements of mobile DNA. One unusual feature of Fukatsuia is its strong tendency to occur as a co-infection with H. defensa. However, the overall similarity of gene inventories among aphid heritable facultative symbionts suggest that metabolic complementarity is not the basis for co-infection, unless playing out on a H. defensa strain-specific basis. We also compared the pea aphid Fukatsuia with a strain from the aphid Cinara confinis (Lachninae) where it is reported to have transitioned to co-obligate status to support decaying Buchnera function. Overall the two genomes are very similar with no clear genomic signatures consistent with such a transition, which suggests co-obligate status in C. confinis was a recent event.
Objectively Measured Physical Activity in Asymptomatic Middle-Aged Men Is Associated With Routine Blood-Based Biomarkers
Authors: Pencina Karol M , Li Zhuoying , Montano Monty 
Published: November 2019

Abstract

Background
The use of circulating clinically routine biomarkers and volitional physical activity using wristband accelerometry in preclinical middle-aged adults may provide sensitive measures of physical function and predict sooner the onset of age- and HIV-related physical decline.

Methods
Nested cross-sectional cohort study of adult men 50–65 years old with HIV infection on potent antiretroviral therapy and uninfected control participants within the Boston metropolitan area. Gait speed derived from wristband accelerometry, gait speed derived from a standardized 6-minute walk test, cellular immune biomarker levels (CD4 T cell, CD8 T cell), and serum anabolic biomarker levels (total and free testosterone, and sex-hormone-binding globulin) were measured.

Results
Of the five measured biomarkers, four were significantly associated with volitional gait speed based on accelerometry, whereas only one was associated with gait speed based on the 6-minute walk test collected in a laboratory environment.

Conclusion
Levels of selected immune and anabolic biomarkers were associated with volitional physical activity in middle-aged individuals. Digital and circulating biomarkers may be useful in future studies designed to identify presymptomatic individuals at increased risk for age- and HIV-associated functional decline.
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities
Authors: Gurinovich Anastasia , Andersen Stacy L , Puca Annibale , Atzmon Gil , Barzilai Nir , Sebastiani Paola 
Published: November 2019

AbstractAPOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer’s disease and early mortality and therefore its prevalence among people with extreme longevity (EL) is low. Using the PopCluster algorithm, we identified several ethnically different clusters in which the effect of the e2 and e4 alleles on EL changed substantially. For example, PopCluster discovered a large group of 1,309 subjects enriched of Southern Italian genetic ancestry with weaker protective effect of e2 (odds ratio [OR] = 1.27, p = .14) and weaker damaging effect of e4 (OR = 0.82, p = .31) on the phenotype of EL compared to other European ethnicities. Further analysis of this cluster suggests that the odds for EL in carriers of the e4 allele with Southern Italian genetic ancestry differ depending on whether they live in the United States (OR = 0.29, p = .009) or Italy (OR = 1.21, p = .38). PopCluster also found clusters enriched of subjects with Danish ancestry with varying effect of e2 on EL. The country of residence (Denmark or United States) appears to change the odds for EL in the e2 carriers.
Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals
Authors: Earls John C , Rappaport Noa , Heath Laura , Wilmanski Tomasz , Magis Andrew T , Schork Nicholas J , Omenn Gilbert S , Lovejoy Jennifer , Hood Leroy , Price Nathan D 
Published: November 2019

AbstractBiological age (BA), derived from molecular and physiological measurements, has been proposed to better predict mortality and disease than chronological age (CA). In the present study, a computed estimate of BA was investigated longitudinally in 3,558 individuals using deep phenotyping, which encompassed a broad range of biological processes. The Klemera–Doubal algorithm was applied to longitudinal data consisting of genetic, clinical laboratory, metabolomic, and proteomic assays from individuals undergoing a wellness program. BA was elevated relative to CA in the presence of chronic diseases. We observed a significantly lower rate of change than the expected ~1 year/year (to which the estimation algorithm was constrained) in BA for individuals participating in a wellness program. This observation suggests that BA is modifiable and suggests that a lower BA relative to CA may be a sign of healthy aging. Measures of metabolic health, inflammation, and toxin bioaccumulation were strong predictors of BA. BA estimation from deep phenotyping was seen to change in the direction expected for both positive and negative health conditions. We believe BA represents a general and interpretable “metric for wellness” that may aid in monitoring aging over time.
Effect of solute concentration on the spectral induced polarization response of calcite precipitation
Authors: Izumoto Satoshi , Huisman Johan Alexander , Wu Yuxin , Vereecken Harry 
Published: November 2019

SUMMARY
Induced calcite precipitation is used in geotechnics to modify the mechanical and hydrological properties of the underground. Laboratory experiments have shown that spectral induced polarization (SIP) measurements can detect calcite precipitation. However, the results of previous studies investigating the SIP response of calcite precipitation were not fully consistent. This study aims to investigate how the SIP response of calcite depends on solute concentration to explain the differences in SIP response observed in previous studies. A four-phase experiment with SIP measurements on a column filled with sand was performed. In phase I, calcite precipitation was generated for a period of 12 d by co-injecting Na2CO3 and CaCl2 solutions through two different ports. This resulted in a well-defined calcite precipitation front, which was associated with an increase in the imaginary part of the conductivity ($\sigma ^{\prime\prime}$). In phase II, diluted solutions were injected into the column. This resulted in a clear decrease in $\sigma ^{\prime\prime}$. In phase III, the injection of the two solutions was stopped while calcite precipitation continued and solute concentrations in the mixing zone decreased. Again, this decreased $\sigma ^{\prime\prime}$. Finally, the injection rate of the Na2CO3 solution was reduced relative to that of the CaCl2 solution in phase IV. This resulted in a shift of the mixing zone away from the calcite precipitation front established in phase I and an associated decrease of $\sigma ^{\prime\prime}$. These results imply that the SIP response of calcite is highly sensitive to the solute concentration near the precipitates, which may explain previously reported conflicting results.
Fucoidan suppresses the gastric cancer cell malignant phenotype and production of TGF-β1 via CLEC-2
Authors: Xu Ling , Liu Fenglin , Li Can , Li Shuxuan , Wu Hao , Guo Bao , Gu Jianxin , Wang Lan 
Published: November 2019

Abstract
The sulfated polysaccharide fucoidan displays excellent anticancer properties with low toxicity in many kinds of cancers. However, its detailed pharmacological effect and mechanism of action in gastric carcinoma remains unclear. In this study, we found that fucoidan could suppress gastric cancer (GC) cell growth, as well as cell migration and invasion. A cytokine expression screen demonstrated that transforming growth factor beta 1 (TGF-β1) secretion was decreased in fucoidan-treated cells. Fucoidan has been reported to be a platelet agonist for the C-type lectin-like receptor 2 (CLEC-2), and our previous research found that upregulation of CLEC-2 inhibited GC progression. Here, we confirmed that fucoidan, combined with CLEC-2, significantly increased CLEC-2 expression in GC cells via the transcription factor caudal type homeobox transcription factor 2, an important regulator of gut homeostasis. In addition, the inhibitory effect of fucoidan on the GC cell malignant phenotype and TGF-β1 secretion could be restored by knocking down CLEC-2. Thus, our data suggest that fucoidan targets CLEC-2 to exert antitumorigenesis and antimetastatic activity, suggesting that fucoidan is a promising treatment for gastric carcinoma.
Health system productivity in China: a comparison of pre- and post-2009 healthcare reform
Authors: Chai Peipei , Zhang Yuhui , Zhou Maigeng , Liu Shiwei , Kinfu Yohannes 
Published: November 2019

AbstractIn 2009, China launched an ambitious health system reform that combined extending social health insurance scheme with improving efficiency, access and quality of care in the country. To assess the impact of the policy on efficiency and productivity change, we investigated the country’s health system performance at provincial levels during pre- and post-reform period. Outputs were measured using multiple health outcomes (namely, non-communicable diseases free healthy life years and infant and maternal survival rates), while health expenditure, number of medical personnel and hospital beds per 1000 residents were used as proxy measures for health inputs. Changes in productivity were quantified using a bootstrap Malmquist productivity index (MPI). The analysis focused on the period between 2004 and 2015. This was to capture pre- and post-policy implementation experience and to ensure that enough time was allowed for the policy to work through. Finally, a bootstrap Tobit regression model for panel data was applied to examine the potential effects of contextual factors on productivity change. The result showed that the reform has had negative effects on productivity. Only scale efficiency had improved steadily, but the decline in the scale of technological change observed during the same period meant that the progress in scale efficiency had been masked. Better economic performance (as measured by per capita Gross Domestic Product (GDP)) and higher human resource to capital investment ratio (as measured by density of medical staff per hospital beds) tended to boost productivity growth, while population aging, low educational attainment and higher percentage of out-of-pocket (OOP) payments had adverse effects. Improving health system productivity in China requires improving financial risk protection and maintaining proper balance between human and capital investment in the country.
Different but not opposed: perceptions between fishing sectors on the status and management of a crab fishery
Authors: Obregón Clara , Tweedley James R , Loneragan Neil R , Hughes Michael 
Published: November 2019

AbstractFisher perceptions are a useful source of information that allows changes in stocks to be detected quickly and indicate the social acceptability of different management regulations. Yet traditionally, such information is rarely employed when developing management approaches. Face-to-face interviews were used to elicit recreational and commercial fishers’ perceptions of a crab (Portunus armatus) fishery in three south-western Australian estuaries. Differences in the perceived changes in the average size of crabs and fishing effort, reported concerns and supported solutions were detected among the recreational fishers utilizing the three estuaries and between recreational and commercial fishers in the Peel-Harvey Estuary. However, some common views were expressed by recreational and commercial fishers, with both sectors stating concerns over recreational fisher compliance and increased fishing and environmental pressures. While both sectors believed that reducing fishing and increasing compliance would benefit crab stocks, the mechanisms for achieving this differed. Recreational fishers favoured increasing the length of the seasonal closure, while commercial fishers favoured the introduction of a recreational shore-based fishing licence. These findings suggest that sector- and estuary-specific management rules may better facilitate the amelioration of pressures affecting individual estuaries and could contribute towards a more socially and biologically sustainable fishery.
Assessing the Potential Infection of Tagosodes orizicolus (Hemiptera: Delphacidae) by Rice Hoja Blanca Virus in Texas
Authors: Martin Jaclyn E , Bernal Jimenez Estephanie K , Cruz Maribel G , Zhu-Salzman Keyan , Way Michael O , Badillo-Vargas Ismael E 
Published: November 2019

AbstractTagosodes orizicolus (Muir) is the most important pest of rice in Latin America. Besides causing direct damage called hopperburn from feeding on and ovipositing in rice leaves, this insect pest also transmits rice hoja blanca virus (RHBV, Family Phenuiviridae, Genus Tenuivirus) in a persistent-propagative manner. This pathosystem can cause up to 100% yield loss in Latin American rice fields. T. orizicolus and RHBV symptoms were detected in Louisiana, Mississippi, and Florida rice fields in the 1950s, 1960s, and 1980s. However, neither has been detected in the United States since. Two outbreaks of T. orizicolus on ratoon rice occurred in the fall of 2015 and 2018 in counties southwest and south of Houston, TX. Insects were collected from ratoon rice fields by sweep net methods. Insects from the 2015 and 2018 outbreaks were tested individually and in pools of 10, respectively, for RHBV infection and the cytochrome oxidase 1 (CO1) gene from Delphacidae. No insects were positive for RHBV, however, all samples yielded amplicons for the CO1 gene. Furthermore, the CO1 gene from five 2015 individuals was sequenced and found to have a 100% identity to the Fer26_Argentina and 99.81% identity to the DEL074 Venezuela isolates of T. orizicolus. Five new sequences from 2015 individuals have now been deposited in GenBank. It is imperative to stay up to date on the potential invasion and establishment of this exotic pest of rice in Texas and other rice-growing regions of the United States through continued monitoring and research.