bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant and anxiolytic efficacy and tolerability of agomelatine in the treatment of depression after COVID-19 in daily clinical practice (non-interventional study TELESPHOR)
Authors: Medvedev V. E. , Bogolepova A. N. , Morozov D. P. , Kvasnikov B. B. 
Published: December 2024

Depression and anxiety are among the most common disorders observed in patients after COVID-19 coronavirus infection.Objective: to evaluate the antidepressant efficacy and tolerability of agomelatine in patients with a depressive episode (DE) after COVID-19 infection in everyday clinical practice.Material and methods. The multicenter observational study TELESPHOR included outpatients aged 18 to 65 years who developed DE (Hamilton Depression Rating Scale (HAMD-17) score of 8–24) within 3 months of the resolution of a laboratory-confirmed COVID-19 infection and started monotherapy with agomelatine. Patients were assessed at enrolment and subsequently at weeks 2, 4 and 8 of the observation period. The primary endpoint was the change in HAMD-17 scores by week 8 of the observation in patients taking agomelatine as an antidepressant. The main secondary outcome variables were the dynamics of scores for items 10 (psychic anxiety) and 11 (somatic anxiety) of the HAMD-17 scale, the proportion of responders and remitters (according to the HAMD-17 scale) and the impact on quality of life (QOL) according to the SF-36 questionnaire. The tolerability of agomelatine was assessed at each visit. Data from all patients who participated in the study and took agomelatine at least once were included in the efficacy and safety analysis. The final analysis included data from 103 patients, including 73 women (70.9%).Results. Treatment with agomelatine was associated with a significant improvement in depression severity: the mean HAMD-17 total score decreased statistically significantly at weeks 2, 4 and 8 from 16.3±4.7 at study inclusion to 13.7±4.5, 9.5±4.9 and 5.4±3.6 points – by 2.6±3.3, 6.7±5.3 and 10.9±4.9 points, respectively, compared to baseline (p<0.0001 for all time points). The average score for item 10 (psychic anxiety) and item 11 (somatic anxiety) of the HAMD-17 scale also decreased significantly from 1.4±0.9 and 1.3±0.8 at baseline to 0.5±0.6 and 0.6±0.6 points by the eighth week of observation (p<0.0001). The indicators of the scales for physical functioning and mental health of the SF-36 questionnaire improved significantly compared to the initial values – from 39.7±8.4 to 50.5±5.7 points (p<0.0001) and from 37.3±8.6 to 58.7±6.9 points (p<0.0001) respectively, by the eighth week. The proportion of responders was 81.4 %, the proportion of remitters was 71.6%. Agomelatine was well tolerated during the entire observation period. No adverse events were recorded that led to discontinuation of the drug. One patient showed inefficacy of the treatment, so he discontinued participation in the study.Conclusion. The treatment of patients with DE after COVID-19 with agomelatine is characterized by significant antidepressant and anxiolytic efficacy, improved QOL and good tolerability.
Language Features Used by Main Female Character in the Movie Redeeming Love (2022)
Authors: Amar Rizki Oktavianti , Wulandari Dwi 
Published: December 2024

The research an titled "Language Features Used by Main Female Character in the Movie Redeeming Love (2022) focuses on identifying and describing specific women’s language features utilized by Angel as the main female character in the movie Redeeming Love. The research also aims to examine the functions of these language features employed Angel with theories of Coates and Holmes were used for these purposes. This descriptive qualitative research utilized purposive sampling to collect data from the Redeeming Love (2022) movie and Redeeming Love movie script. Then, the data were examined by determining and classifying the types of women's language defined by Coates and supported by using Holmes’s theory as a social factor that influences language. The results of the analysis revealed that the main female characters uses all variety of women's language features, including minimal responses, lexical hedges, tag questions, questions, commands and directives, swearing and taboo language, and compliments. Additionally, Angel utterances are mainly used for expressive functions among other. The study also shows social factor that Angel mostly used is participant.
Analysis on the Acculturation of English to Sasak among Sasak Native Speakers
Authors: Khairunnasri Muhammad 
Published: December 2024

AbstractThe purpose of this research is to investigate the acculturation between Sasak language and English among Sasak native speakers, and to identify which words or phrases have been absorbed and used in Sasak daily communication. This research was conducted in Selakerat, Perian Village, Montong Gading District, Lombok Timur Regency. This research uses a qualitative descriptive method. The researcher employed observation, interview, and field note for data collection. The subjects of this study were nine native speakers of Sasak language of various ages residing in Selakerat. The results of this study indicate that language acculturation has occurred between Sasak language and English among Sasak native speakers in Selakerat, Perian Village in their daily communication. Some English words that have been absorbed and are frequently used in daily language include download, transfer, live, loading, log-in, by one, kill, like, top-up, reload, ID (identity), pet, peach, emote, skill, bot, gold, platinum, eyeliner, rank, map, lobby, account, make-up, cream, skincare, SIM (subscriber identity module), content, creator, skin, match, event, diamond, cream, viral, and pink, and several phrases like fake account (account fake), eye shadow, triple kill and trial emote (emote trial).
La justicia transicional como garantía de no repetición: el modelo colombiano puesto a prueba
Authors: Londoño Lázaro Maria Carmelina , Idárraga Martínez Ana María 
Published: December 2024

El diseño de un modelo de transición a la paz requiere abordar las causas del conflicto para evitar la repetición de violaciones masivas y sistemáticas de derechos humanos. Así vista, la justicia transicional (JT) constituiría una garantía de no repetición (GNR), en la medida en que busca corregir las fallas estructurales que subyacen a tales violaciones, con el fin de prevenir ilícitos continuos o repetitivos. Esta investigación explica cómo el modelo de justicia transicional colombiano ha integrado las GNR, los aportes que ofrece este diseño para otros procesos transicionales y algunas alertas. Por su contenido y finalidad, el artículo es de interés para una amplia audiencia: para quienes están a cargo del diseño, del seguimiento y de la implementación de mecanismos de JT, académicos y todos aquellos que desean comprender la panorámica del sistema de transición colombiano, las posibilidades y los desafíos que implica ese deseado “no volver atrás”.
Laboratory Setup and Exercise to Evaluate the Characteristics of Different Earthing Systems
Authors: Barchet Max , Biehl Volker 
Published: December 2024

Abstract
In the bachelor program Medical Engineering, we have introduced the elective course Safety of Medical Electrical Equipment Lab Exercises. One of the lab exercises deals with the topic characteristics of different earthing systems and electricity supply networks in medical used areas. A laboratory setup has been developed and introduced for this lab exercise. With this setup it is possible to evaluate the characteristics of different earthing systems with extra-low voltage in order to avoid hazardous situations.
Hyper-viscoelastic characterization of the urethra
Authors: Bhave Ashish , Joshi Jash , Yache Vaishnavi , Rupitsch Stefan J. , Moeller Knut 
Published: December 2024

Abstract
Hyper-viscoelastic models have been used to characterize large strains coupled with viscosity. In this study, we aimed to model the urethral in-vivo biomechanics through a hyper-viscoelastic implementation. First, we used isotropic 2-parameter Demiray model for identification of urethral tube inflation after refining the values of quasistatic states. Attempting the approach by Holzapfel et. al., the average ratio of the elastic and dynamic modulus was computed to determine the stress contribution of the viscoelastic branches. The values of the parameters were determined after constraining a constant Energy dissipation (generalized maxwell) over range 1s to 100s. For the hyper-viscoelastic comparison implementation, it was observed that the goodness of fit criteria performs good for half of the samples (Adjusted R2>0.95). In some samples, the model is limited to fit ‘S’ shape curves but still performed well. The above identification technique and the hyper-viscoelastic in-silico approaches show that our approach fares sufficiently for the creep response characterization of the urethra.
EMG pants for smart textile-based monitoring of the muscle activity in the pelvic floor in physical therapy
Authors: Blocher Sandra , Linti Carsten , Jachan Deborah , Metter Joachim , Eberhardt-Fonseca André , Liebeton Esther , Bartsch Valérie , Gresser Götz T. 
Published: December 2024

Abstract
People worldwide suffer from bladder incontinence. For patients it is difficult to train the pelvic floor without a physiotherapist. The aim of this paper is to show how smart textiles can be applied in telemedicine. Textile electrodes and conductive paths are embroidered into underwear. The electromyography (EMG) signals of the pants are sent to an app. The app visualizes the data of the muscle activity.
Estimating safety factor for femoral plates subjected to in vivo loads
Authors: Bologna Federico Andrea , Audenino Alberto Luigi , Terzini Mara 
Published: December 2024

Abstract
Fatigue behaviour is a crucial aspect of mandatory mechanical tests for regulatory purposes, aimed at determining the load at which the bone plate withstands under a specific number of cycles, known as the runout condition. However, current test standards, such as ASTM F382, provide setup configurations without explicit guidelines on required fatigue strength. The determination of the minimum level of in vivo performance that the plate must fulfil remains an open issue, which is frequently addressed by the direct comparison with predicate devices. To address this gap, this study proposes an in silico framework to estimate maximum stress on implanted femoral plates for comparison with four-point bending tests described in the ASTM standard, deriving appropriate safety factors. As case studies, three femoral plates were assessed, and results showed safety factors above 1.1, indicating the reliability of the implanted plates.
Investigating the bending properties of cardiovascular catheters and stents via three-point bending test setup
Authors: Brandt-Wunderlich Christoph , Lenz Christopher , Siewert Stefan , Stiehm Michael , Schmitz Klaus-Peter , Schmidt Wolfram 
Published: December 2024

Abstract
The bending properties of catheters and stents have a big influence on their success during clinical application. Whereas bending stiffness directly affects the trackability of catheters, stents underlie bending when used for renal, superficial femoral or femoro-popliteal arteries, respectively. A three-point bending test setup according to ASTM F2606 was implemented into a universal testing machine and was validated regarding influence parameters such as accuracy of force measurement, test speed and span length. The bending stiffness can be calculated from the initial linear portion of the force-deflection curve. Furthermore, a multi-cycle approach was developed to evaluate the bending properties at large deformations revealing the deflection depending peak load as well as deflection depending elastic recovery rate after unloading. Within this study samples with a length of 120 mm from the proximal region of a commercial coronary balloon catheter were used. Influence of test speed was not significant. However, bending stiffness increased with increasing span length. For multi-cycle measurements a constant test speed and constant span length was used. Test results showed an increasing plastic deformation and peak load as well as a decreasing elastic recovery rate as expected. The presented test method can be used for catheters as well as stents with a length diameter ratio of at least 4:1.
A Custom-Built Piezo-Optical System for Visualization and Characterization of High Intensity Focused Ultrasound
Authors: Brecht Luisa , Steinmeyer Florian , Bonekamp Jörg-Bernd , Partanen Ari , Grüll Holger , Lindemeyer Johannes 
Published: December 2024

Abstract
High intensity focused ultrasound (HIFU) is a noninvasive treatment technique to induce thermal or mechanical bioeffects. Characterising the wave field is essential for reliable and reproducible transducer operation in clinical use. This paper presents a schlieren technique to visualise and quantify transducer wave fields. The technique is based on the piezo-optical effect of water, i.e. the refractive index variation caused by sound pressure. Our custom-built system equipped with a Raspberry Pi HQ camera can capture schlieren photographs of acoustic fields generated by a clinical HIFU system. Alternatively, a high-speed camera allows analysis of short burst pulses. We investigated the focal zone shape of continuously generated HIFU fields at acoustic powers of 10- 250 W. Images of the focal area at 100 W indicated dimensions comparable to the reported literature values. Notably, as power increases, we observe waveform distortion in the focal zone due to nonlinear propagation of ultrasound. Our findings demonstrate the efficacy of our system in visualizing and characterizing the acoustic fields generated by a clinical HIFU device.
Core-Shell Capsule Image Segmentation through Deep Learning with Synthetic Training Data
Authors: Budde Leon , Dreger Julia , Egger Dominik , Seel Thomas 
Published: December 2024

Abstract
Core-shell capsules (CSC) are a promising approach for 3D cell culture because they overcome the challenges of traditional large-scale cell cultivation techniques used in tissue engineering. Currently, CSC are segmented from microscopic images in a cumbersome manual procedure to evaluate their properties, such as size or complete encapsulation of the core compartment. In this paper, we propose an automated segmentation process of CSC based on an unmodified YOLOv8 instance segmentation model.We train the model exclusively on synthetic CSC images created from 10 manually annotated real images and evaluate its performance using the common Intersection over Union (IoU) metric on a test set consisting of 181 real images. Without modifying the model or tuning the hyperparameters, we achieve a mean IoU of 0.86, underlining the potential of deep-learning-based CSC segmentation relying entirely on synthetic training data.
Proof of the effectiveness of novel bioinspired antimicrobial nanostructures
Authors: Buhl Sebastian , Stich Alexander , Bulitta Clemens , Zapata Camilo , Paniagua Sergio 
Published: December 2024

Abstract
Antimicrobial surfaces are a promising option for supporting hygiene measures. In addition to many different technologies, research is also ongoing into coatings that are modelled on natural surfaces. In an international project with the National Nanotechnology Laboratory in Costa Rica, the Technical University of Applied Sciences Amberg-Weiden is working on such an aluminum-based nanostructured coating, which is modelled on insect wings and has an antibacterial effect in nature. The aim is to test the effectiveness of these surfaces against bacterial pathogens (Escherichia coli and Staphylococcus aureus) in a standard test procedure, as well as to investigate the resistance of the nanostructures to abrasion and reprocessing. Since the effect of such surfaces depends on the filigree nanostructure, resistance to possible abrasion or damage is a key factor here. Our results show that these coatings exhibit at least detectable activity (log 2.2) against the bacteria in the ISO 22196 test setup. Even after repeated wiping of the coatings with sterile water or reprocessing using ultrasound and wipe disinfection, no loss of effectiveness can be detected. Due to the intrinsic antimicrobial effect of the aluminum, the effectiveness of the nanostructured surface is even higher compared to a completely ineffective control surface. If further studies confirm these initial positive results, the coating we investigated could represent another effective alternative in infection control and prevention.
Patterns of pulsatile impedance change during the apnea test detected by electrical impedance tomography
Authors: Chen Rongqing , Krueger-Ziolek Sabine , Lovas András , Benyó Balázs , Bakos Péter , Chase J. Geoffrey , Rupitsch Stefan J. , Moeller Knut 
Published: December 2024

Abstract
The apnea test (AT) is a critical procedure in determining brain death. It temporarily disconnects the patient from the ventilator for 7 to 10 minutes. This study explores pulsatile Electrical Impedance Tomography (EIT) during AT in 10 patients suspected of brain death to discern physiological changes. Analysis revealed three distinct patterns of pulsatile EIT signal changes: increasing; fluctuating; and decreasing. These findings show the potential of pulsatile EIT monitoring to provide novel insight into cardio-pulmonary dynamics during AT.
The EU AI Act’s Impacts on Digital Health
Authors: Djeffal Christian , Mehl Philipp , Müller Verena 
Published: December 2024

Abstract
The European Artificial Intelligence Act (AI Act) has profound implications for technological innovation in the medical and health care sector, transcending the boundaries of existing legal frameworks such as the Medical Device Regulation (MDR) and the General Data Protection Regulation (GDPR). This paper examines basic regulatory choices of the AI Act relevant for the field of digital health innovations by contextualizing its main goals, key obligations, and addressed actors. In light of these considerations, we present a scoping literature review that identifies potential regulatory challenges for stakeholders engaged in research, innovation and healthcare. Building on this, we point to concepts and methodologies to overcome such challenges in a way fostering innovation while realizing key constitutional and societal interests at the same time.
MR-Compatible Pump for the Validation of PC-MRI Flow Measurements
Authors: Ebers Kevin , Huber Florian , Radermacher Klaus , Benninghaus Anne 
Published: December 2024

Abstract
The technique of PC-MRI flow measurement offers a great opportunity to diagnose and understand the pathogenesis of various diseases and clinical pictures. Although previously criticized for its lack of accuracy, the method is now expanding the possibilities in several research areas. In this study, the design of an MR-compatible pump for the validation of PC-MRI flow measurements is presented. Initial PC-MRI measurements have demonstrated MRcompatibility and the ability to record artifact-free flows. The flow generated by the pump was further measured with an ultrasound flow sensor and compared with a physiological flow curve. The results showed that both the course and the minima and maxima match. Thus, the resulting pump generates a bidirectional, pulsatile flow within a physiological range and a variable frequency between 60-90 rpm with a stroke volume of 0.9 ml. Further flows, frequencies and stroke volumes can be adjusted. This enables the validation of PCMRI flow measurements and addresses current difficulties such as the lack of in vivo data.
Characterizing Human Walking Dynamics Across Age: A Control Engineering Approach
Authors: Feld Lea , Hellmers Sandra , Schell-Majoor Lena , Koschate Jessica , Zieschang Tania , Kollmeier Birger , Hein Andreas 
Published: December 2024

Abstract
Introduction While various models and studies have investigated the simulation and theoretical description of human gait, previous research has not considered irregular situations such as slipping and tripping. However, understanding these situations could be crucial and provide insight into assessing dynamic balance, a factor that is closely linked to the risk of falling. The first step is to investigate the system under normal walking using a participant group that includes people who are particularly susceptible to an increased risk of falling, such as older adults or people with certain health conditions that have so far been neglected in the literature. Methods In this study a control engineering approach was used to estimate the parameters of the human gait system. A total of 42 subjects aged 18 to 78 years, with different body masses and walking speeds, were analyzed. Measurements were conducted on a treadmill with integrated force plates, while participants wore inertial measurement units (IMUs) at lumbar level and were filmed with cameras. Results The calculated spring-mass-damping model parameters, including stiffness (k) and damping (c), varied widely among participants, with stiffness ranging from 4.45 to 45.53 kN/m and damping from 0.26 to 2.13 kNs/m. Contrary to previous findings, no linear relationships were observed between stiffness or damping and velocity, age, or mass. Outliers were identified and related in a plausible way to visual inspection. Conclusion In conclusion, our study successfully characterized human walking during periodic excitation for a diverse participant group using a simple control engineering approach, yielding comparable results to previous studies. Our results pave the way for future investigations to analyze the response of an individual participant to irregular gait perturbations.
Biomedical Entrepreneurship Initiative - a Novel Online Education Program towards a conference competition (IEEE CAS)
Authors: Friebe Michael 
Published: December 2024

Abstract
It is recognized that teaching and embracing entrepreneurial skillsets lead to more valuable and impactful innovations in biomedical engineering. Unfortunately only very few institutions globally have started to integrate innovation generation methods and entrepreneurial mindset development in their curricula. A novel approach was developed and tested for the IEEE CASS society. A 6 week online training program was developed (30 videos, worksheets, deliverables, and regular tests) and subsequently advertised leading the participants, accompanied by weekly personal guidance, to create a real innovation project. This was embedded in a competition to allow the best teams to receive funding to be able to attend the annual society conference and participate in a competition. The learners all reported a changed mindset towards innovation generation and the presented results were stimulating and exciting. The paper provides details on the free training program and shows some of the results. This could - and maybe should - become a standard training and program event point at future biomedical engineering conferences.
Development of an intraoperative monitoring system for microwave ablations
Authors: Gölz Oliver , Radler Philipp , Deininger Johannes , Lebhardt Philipp , Langejürgen Jens 
Published: December 2024

Abstract
Microwave ablation therapy is frequently used to treat liver malignancies. To ensure proper tumor treatment, intraoperative feedback regarding ablation performance and lesion size is required. By employing an electrode array around the ablation needle, changes in electrical impedance of ex vivo liver are measured in real time. Time-series trends of magnitude and phase are measured for 90 °C and 110 °C ablation temperatures. A finite element model is additionally configured to simulate the underlying biological processes. Gradients in the magnitude and phase trends can indicate the growth of the ablation zone. In combination with a preoperative simulation, impedance-based ablation monitoring can be a possible tool to improve future treatments.