bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors
Authors: Mikedis Maria M. , Fan Yuting , Nicholls Peter K. , Endo Tsutomu , Jackson Emily K. , Cobb Sarah A. , de Rooij Dirk G. , Page David C. 
Published: March 2020

AbstractFertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model andin vivobiochemical approaches combined with chemical synchronization of spermatogenesis. We find that the absence ofDazlimpairs both expansion and differentiation of the spermatogonial progenitor population. In undifferentiated spermatogonia, DAZL binds the 3’ UTRs of ∼2,500 protein-coding genes. Some targets are known regulators of spermatogonial proliferation and differentiation while others are broadly expressed, dosage-sensitive factors that control transcription and RNA metabolism. DAZL binds 3’ UTR sites conserved across vertebrates at a UGUU(U/A) motif. By assessing ribosome occupancy in undifferentiated spermatogonia, we find that DAZL increases translation of its targets. In total, DAZL orchestrates a broad translational program that amplifies protein levels of key spermatogonial and gene regulatory factors to promote the expansion and differentiation of progenitor spermatogonia.
Synchronous Caregiving from Birth to Adulthood Tunes Humans’ Social Brain
Authors: Ulmer-Yaniv Adi , Salomon Roy , Waidergoren Shani , Shimon-Raz Ortal , Djalovski Amir , Feldman Ruth 
Published: March 2020

AbstractMammalian young are born with immature brains and rely on the mother’s body and caregiving behavior for maturation of neurobiological systems that sustain adult sociality. However, the parent-child precursors of humans’ social brain are unknown. We followed human neonates, who received or were deprived of maternal bodily contact, to adulthood, repeatedly measuring mother-child interactive synchrony. We tested the neural basis of empathic accuracy in adulthood and utilized multivariate techniques to distinguish brain regions sensitive to others’ distinct emotions from those globally activated by the vicarious stance. A network comprising the amygdala, insula, and temporal pole underpinned empathic accuracy, which was shaped by mother-child synchrony across development. Synchronous experiences with mother or father in infancy impacted adults’ neural empathy, highlighting the benefits of humans’ bi-parental rearing. Findings demonstrate the centrality of synchronous caregiving across development for tuning humans’ social brain.
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
Authors: Obst Juliane , Simon Emilie , Martin-Estebane Maria , Pipi Elena , Barkwill Liana M. , Gonzalez-Rivera Ivette , Buchanan Fergus , Prescott Alan R. , Faust Dorte , Fox Simon , Brownlees Janet , Taylor Debra , Perry V. Hugh , Nuthall Hugh , Atkinson Peter J , Karran Eric , Routledge C , Gomez-Nicola Diego 
Published: March 2020

AbstractThe proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and prion disease. Colony stimulating factor 1 receptor (CSF1R) is critically involved in regulating microglial proliferation, and CSF1R blocking strategies have been recently used to modulate microglia in neurodegenerative diseases. However, CSF1R is broadly expressed by many cellular types and the impact of its inhibition on the innate immune system is still unclear. CSF1R can be activated by two independent ligands, CSF1 and interleukin 34 (IL-34). Recently, it has been reported that microglia development and maintenance depend on IL-34 signalling. In this study, we evaluate the inhibition of IL-34 as a novel strategy to reduce microglial proliferation in neurodegenerative diseases, using the ME7 model of prion disease. Selective inhibition of IL-34 showed no effects on peripheral macrophages populations in healthy mice, avoiding the side effects observed after CSF1R inhibition on the systemic compartment. However, we observed a reduction in microglial proliferation after IL-34 inhibition in prion-diseased mice, indicating that microglia could be more specifically targeted by reducing IL-34 and that this ligand plays an important role in the modulation of microglia population during neurodegeneration. Overall, our results suggest that control of microglial response through IL-34 blockade could be a potential therapeutic approach in neurodegenerative diseases.
Theoretical foundations of antecedents of internationalization and moderators in multinationality–performance relationship
Authors: Purkayastha Anish , Sharma Sunil , Karna Amit 
Published: March 2020

PurposeIn this paper, the authors undertake a systematic analysis of multinationality–performance (M-P) literature published in the last decade, when antecedents for internationalization and moderators of theM-Prelationship had attained a center stage in international business and international management research. ThoughM-Prelationship is one of the most widely studied topics within international business literature, so far synthesis of the entire theoretical landscape is missing in extant literature.Design/methodology/approachThrough keywords search process, the authors found 111 studies in management literature that look at internationalization, its antecedents, performance of internationalized firms, and moderators of theM-Prelationship. The focus of this study is to identify theoretical foundations used to explain the antecedents and moderators inM-Prelationship, in order to suggest the future research direction for the field. The authors classify the antecedents and moderators based on their theoretical underpinnings not only to identify commonly used theoretical foundations in the last 10 years of international strategy research but also to highlight potential areas for future research.FindingsThe authors’ analysis indicates that research on international strategy in the last decade was dominated by theory testing in the context of developed economies. The authors’ review suggests that majority of the antecedents and moderators in theM-Prelationship are anchored within institutional theory, organizational structure, resource-based view, social capital, and upper echelon theory.Originality/valueThe authors’ findings are indicative of a rich research potential ofM-Prelationship in the contextual research setting of emerging markets while leveraging more diversified theoretical bases and multiple levels of research design.
Investigating the significance of risks in BOT transportation projects in Vietnam
Authors: Le Phuong Thi , Chileshe Nicholas , Kirytopoulos Konstantinos , Rameezdeen Raufdeen 
Published: March 2020

PurposeThe Built Operate Transfer (BOT) model has been increasingly used in transportation investments in Vietnam. However, there is still an inadequacy of risk management applications in these projects and lack of research in this area. The study aims to improve the success of projects implemented through the BOT model in Vietnam.Design/methodology/approachThe study followed a sequential design including interviews and a questionnaire survey to investigate the perception of stakeholders from public and private sector regarding the probability of occurrence and the severity of impact of risks in BOT transportation projects in Vietnam. Quantitative data from the survey was subjected to descriptive and inferential statistics to explore the priority of risks as well as the differences in the perception between the public and private sectors.FindingsThe results showed that the top five most significant risks in BOT transportation projects in Vietnam are: (1) problems with land acquisition and compensation, (2) inappropriate location of toll booths, (3) public resistance to pay, (4) high toll rate and (5) lack of cash flow. With the exception of “lack of cash flow,” there were no statistically significant differences in the rankings of individual risks between the public and private sector. In addition, there is a significant positive correlation in the overall rankings of all risks for both sectors.Originality/valueThis study contributes to the body of knowledge by exploring the probability of occurrence and the severity of the impact of risks in BOT transportation projects in a developing country like Vietnam which has not been extensively explored yet. Second, it provides an insight into the perception of stakeholders from the public and private sector regarding the level of risks which is very useful for potential stakeholders in making decisions when they intend to participate in such partnerships. Third, it enables the Vietnamese government to establish suitable policies related to such projects. These contributions are very important in improving risk management in PPPs in developing countries.
Rewarding employee inventions in corporations
Authors: Svačina Pavel 
Published: March 2020

PurposeReasonable remuneration of employee inventions is a controversial issue causing court litigations among employees and employers in many countries. The paper aims to shed light on the missing economic interpretation of the reasonable remuneration of employee inventions. Specifically, it focuses on the concept of “reasonability” at the issue.Design/methodology/approachIn an empirical qualitative multiple case-study setting, the paper explores inductively Czech corporate employee inventors' remuneration systems, using typological analysis and M. Weber's interpretative theoretical construct of “ideal type.”FindingsAt the first level, reasonability is a function of multi-amount rewarding, a certain level of total remuneration and identifiable benefits being a decisive factor. Additionally, the reasonability is conceptualised as a function of two dimensions – timing/risk and benefit–reward relation. At the second level, the reasonability is interpreted as a concept balancing seven points of view: timing, materiality, equity, risk management, transparency, system costs and exactness. At the third level, the paper offers an optimal remuneration system like the one that optimises developed seven-criterion framework.Research limitations/implicationsEven if analysed within one-country and nine-company context, the insights are generalisable across a broader sample of countries with statutory rules for employee inventions. Studying more cases may enrich the findings. The findings are based merely on a rational perspective and do not deal with psychological aspects of employees.Practical implicationsThe results may be helpful for intellectual property or R&D managers in building or reorganising employee invention remuneration systems within corporations. The developed seven-criteria model can serve as a discussion framework; the suggested optimal system as a reference point. The results may serve as well to consultants, judges or other parties involved in currently growing employee–employer controversies and litigations. The analysis may fuel public policy decisions, too.Originality/valueThe paper brings unique and detailed empirical insights into the issue of employee inventions. It offers a complex multi-perspective (employee/employer) framework through which the reasonability can be discussed and suggests an optimal system, which can serve as a reference point.
Developing inclusive and collaborative entrepreneuring spaces
Authors: Patterson Nicola 
Published: March 2020

PurposeThe call for more women to start up and grow businesses as a vehicle for economic vibrancy is a prevailing discourse in the UK. There have been calls for greater co-ordination between research, policy and practice to create collaborative spaces whose focus is to influence and shape structures and processes beyond the individual or community level to a macro level of enterprise policy. However, calls have not specifically focussed on the issues of gender or other categories of social difference. This study aims to understand how such co-ordinations can be established to enable progress within the women’s entrepreneurship space through the development of collaborative spaces fusing research, policy and practice and how they should be structured to ensure inclusion through the process as well as enabling greater inclusion as part of the collaborative space outcome.Design/methodology/approachTaking a critical feminist perspective, the study draws from extant literature on women and minority networks research from the women in leadership, diversity and inclusion fields as a lens through which to frame the analysis of women’s enterprise policy in the UK, research and practice.FindingsThe study highlights the importance of collective feminist action drawing upon post-feminist sensibilities and an Engaged–Activist Scholarship approach. Such collective feminist action appreciates the importance of the micro as an enabler to progressive action at the macro level to enact structural and system change within the entrepreneurial ecosystem. A framework for inclusive and collaborative entrepreneuring space development is offered.Practical implicationsThis paper offers policymakers, researchers and practitioners a framework as a practical way forward to ensure efforts are progressive and enable structural and systemic change.Originality/valueThe paper offers a framework for developing inclusive and collaborative entrepreneuring spaces to ensure progression by lifting the focus to a macro level of change to enable inclusion as part of the process and outcome of such collaborative spaces.
Domains of decision-making and forms of capital among men and women teachers
Authors: Grinshtain Yael , Addi-Raccah Audrey 
Published: March 2020

PurposeViewing school as a feminine bias workplace alongside being a field of power relations as argued by Bourdieu, this study examines (1) gender differences among teachers in different forms of capital (cultural, social, and feminine) and in their participation in decision-making (PDM) at school in three domains: managerial, administration, and teaching; (2) the relations between forms of capital and domains of PDM within each gender group.Design/methodology/approachThe study was based on a random sample of 32 schools in Northern Israel that included 595 teachers (454 women; 141 men) who answered a questionnaire, which included background information; teachers' forms of capital; and PDM in managerial, administrative, and teaching domains. Multiple regression analysis was conducted.FindingsMen tend to have an advantage in PDM in managerial issues, while women have an advantage in PDM in teaching. Further, women more than men perceived feminine capital and social capital as contributing to their work. It was also found that more types of capital are related to PDM among women as compared to men. For men, academic cultural capital predicts PDM in the teaching domain. For women, social capital predicts PDM in the three domains; academic cultural capital predicts PDM in the managerial domain; and feminine capital predicts PDM in teaching.Originality/valueThis study focuses simultaneously on different forms of capital, emphasizing the varying contribution of each capital to men and to women teachers. It also offers a set of resources that can demonstrate the complex factors that contribute to teachers' work.
Push recovery control of quadruped robot using particle swarm optimization based structure specified mixed sensitivity H2/H∞ control
Authors: Sutyasadi Petrus , Parnichkun Manukid 
Published: March 2020

Purpose
The purpose of this paper is to introduce a quadruped robot strategy to avoid tipping down because of side impact disturbance and a control algorithm that guarantees the strategy can be controlled stably even in the presence of disturbances or model uncertainties.

Design/methodology/approach
A quadruped robot was developed. Trot gait is applied so the quadruped can be modelled as a compass biped model. The algorithm to find a correct stepping position after an impact was developed. A particle swarm optimization-based structure-specified mixed sensitivity (H2/H∞) robust is applied to reach the stepping position.

Findings
By measuring the angle and speed of the side tipping after an impact disturbance, a point location for the robot to step or the foothold recovery point (FRP) was successfully generated. The proposed particle swarm optimization-based structure-specified mixed sensitivity H2/H∞ robust control also successfully brought the legs to the desired point.

Practical implications
A traditional H∞ controller synthesis usually results in a very high order of controller. This makes implementation on an embedded controller very difficult. The proposed controller is just a second-order controller but it can handle the uncertainties and disturbances that arise and guarantee that FRP can be reached.

Originality/value
The first contribution is the proposed low-order robust H2/H∞ controller so it is easy to be programmed on a small embedded system. The second is FRP, a stepping point for a quadruped robot after receiving side impact disturbance so the robot will not fall.
Rethinking the actor in service research: toward a processual view of identity dynamics
Authors: Koskela-Huotari Kaisa , Siltaloppi Jaakko 
Published: March 2020

PurposeOnly a few concepts in the service literature are as pervasive yet as undertheorized as is the concept of the actor. With a growing interest toward value creation as a systemic and institutionally guided phenomenon, there is a particular need for a more robust conceptualization of humans as actors that adopts a processual, as opposed to a static, view. The purpose of this paper is to build such processual conceptualization to advance service-dominant (S-D) logic, in particular, and service research, in general.Design/methodology/approachThe paper is conceptual and extends S-D logic's institutionally constituted account of the actor by drawing from identity theory and social constructionism.FindingsThe paper develops a processual conceptualization of the human actor that explicates four social processes explaining the dynamics between two identity concepts—social and personal identity—and institutional arrangements. The resulting framework reveals how humans are simultaneously constituted by institutions and able to perform their roles in varying, even institution-changing, ways.Research limitations/implicationsBy introducing new insights from identity theory and social constructionism, this paper reconciles the dualism in S-D logic's current description of actors, as well as posits the understanding of identity dynamics and the processual nature of actors as central in many service-related phenomena.Originality/valueThis paper is among the few that explicitly theorize about the nature of human actors in S-D logic and the service literature.
A social network based approach to identify and rank influential nodes for smart city
Authors: Tidke Bharat Arun , Mehta Rupa , Rana Dipti , Mittal Divyani , Suthar Pooja 
Published: March 2020

Purpose
In online social network analysis, the problem of identification and ranking of influential nodes based on their prominence has attracted immense attention from researchers and practitioners. Identification and ranking of influential nodes is a challenging problem using Twitter, as data contains heterogeneous features such as tweets, likes, mentions and retweets. The purpose of this paper is to perform correlation between various features, evaluation metrics, approaches and results to validate selection of features as well as results. In addition, the paper uses well-known techniques to find topical authority and sentiments of influential nodes that help smart city governance and to make importance decisions while understanding the various perceptions of relevant influential nodes.

Design/methodology/approach
The tweets fetched using Twitter API are stored in Neo4j to generate graph-based relationships between various features of Twitter data such as followers, mentions and retweets. In this paper, consensus approach based on Twitter data using heterogeneous features has been proposed based on various features such as like, mentions and retweets to generate individual list of top-k influential nodes based on each features.

Findings
The heterogeneous features are meant for integrating to accomplish identification and ranking tasks with low computational complexity, i.e. O(n), which is suitable for large-scale online social network with better accuracy than baselines.

Originality/value
Identified influential nodes can act as source in making public decisions and their opinion give insights to urban governance bodies such as municipal corporation as well as similar organization responsible for smart urban governance and smart city development.
Driving consumer–brand engagement and co-creation by brand interactivity
Authors: Cheung Man Lai , Pires Guilherme D. , Rosenberger Philip J. , De Oliveira Mauro Jose 
Published: March 2020

PurposeThis paper investigates the impact of brand interactivity within social media on consumer–brand engagement and its related outcomes, including consumers' intention of co-creating brand value and future repurchase of the same brand.Design/methodology/approachThe theoretical framework is tested for a durable technology product, a smartphone. Data was collected in Brazil from 408 users utilizing a self-administered online survey. Data analysis uses partial least squares–structural equation modelling (PLS-SEM).FindingsEntertainment interactivity, cognitive information-transfer interaction and cognitive up-to-date information interactivity are the key elements directly influencing consumer–brand engagement, enhancing consumers' intention to co-create brand value and to repurchase the brand. Importantly, the impact of interactivity ease of use and customization interactivity on consumer–brand engagement and its related outcomes is non-significant. This is inconsistent with previous studies on consumer–brand engagement.Research limitations/implicationsThe research contributes to the literature by providing an understanding of how to use brand interactivity elements on social-media platforms to strengthen consumer–brand engagement for durable technology products, such as smartphones in Brazil. However, this study is cross-sectional in nature and focus is solely on smartphones in Brazil. Future research might consider a longitudinal design and include comparisons between countries with diverse cultures as well as other industries and product types to enhance the generalizability of the findings.Practical implicationsMarketers may heighten consumer–brand engagement by using content that is entertaining, current and trendy. Incorporating positive referrals on social-media platforms encourages consumers to co-create brand value and to repurchase the same brand in the future.Originality/valueExamination of the role of social-media marketing in the marketing literature largely overlooks the impact of elements of brand interactivity within social media on consumer–brand engagement. This article contributes to social-media marketing and consumer–brand engagement research by empirically testing a theoretical model, confirming that specific elements of brand interactivity within social media – including entertainment interactivity, cognitive information-transfer interaction and cognitive up-to-date information interactivity – are critical drivers in the process of strengthening consumer–brand engagement in Brazil.