bluuebunny/crossref_metadata_2025_split huggingface dataset:
El FOGASA ante el despido de quien se integra en la mercantil que prosigue la actividad
Authors: Gallego Moya Fermín 
Published: December 2020

En contextos de crisis económica, es un fenómeno reconocible el intento de quienes vieron extinguido su contrato de trabajo por cierre de empresa, de reactivar la actividad productiva, constituyendo sociedades limitadas que, con mimbres distintos a los de la economía social, reactivan la actividad de aquella mercantil insolvente o concursada aprovechando su experiencia laboral y los contactos con antiguos proveedores y clientes. Dicha “reconstrucción” de la empresa quebrada se percibe en muchos casos, por el Fondo de Garantía Salarial, como un fenómeno sucesorio que elimina el derecho de dichos trabajadores a percibir las indemnizaciones derivadas de aquella extinción contractual que el órgano de garantía no considera como tal. En este trabajo pretendemos distinguir aquellos supuestos en los que concurre la auténtica sucesión de empresa que neutraliza la intervención del Fondo de Garantía Salarial, de aquellos otros casos en que, siguiendo la interpretación flexibilizadora de nuestros Tribunales ante un panorama de destrucción y escasez del empleo como el actual, se considera compatible la compensación indemnizatoria por el empleo perdido con la nueva prestación laboral que surgió de las cenizas de la vieja empresa.
In contexts of economic crisis, the attempt of those who saw their contract expired due to the closing of the company is a recognizable phenomenon, revive productive activity, constituting limited societies that, with different tools from the social economy, they revive the activity of that insolvent or bankrupt company taking advantage of their work experience, and contacts with former suppliers and customers. This “reconstruction” of the bankrupt company is perceived in many cases, by the Wage Guarantee Fund, as a succession phenomenon which eliminates the right of such workers to receive compensation arising from that contractual extinction which the guarantee body does not consider as such. In this project we intend to distinguish those assumptions in which the true company succession concurs and which neutralizes the intervention of the Wage Guarantee Fund, those other cases in which, following the flexible interpretation of our courts faced with a panorama of destruction and scarcity of employment as the current, compensation for jobs lost with the new labour provision that arose from the ashes of the old company is considered to be compatible.
La impugnación de acuerdos sociales
Authors: Piqueras Casado Lourdes María 
Published: December 2020

Esta investigación tiene como principal propósito llevar a cabo un análisis exhaustivo de la impugnación de acuerdos sociales. Esta materia, recurrente en la práctica mercantil, se ha mantenido en nuestro Derecho sin demasiados cambios durante mucho tiempo. Sin embargo, en 2014 se llevó a cabo la reforma de la Ley de Sociedades de Capital siendo uno de los puntos más tratados la impugnación de acuerdos sociales. Con la reforma se han introducido múltiples novedades que han unificado y mejorado la situación que existía con anterioridad en lo respectivo a la impugnación de los acuerdos societarios. Se han introducido, así mismo, nuevos límites a la acción de impugnación puesto que lo que busca el legislador es mantener la voluntad común de todos los socios y que es el fundamento último por el que se creó la sociedad inicialmente. Así, a lo largo de este proyecto de investigación vemos cuáles son las diferentes novedades y mejoras que aparecen con la reforma operada en 2014 y que se encuentran vigentes en la actualidad.
The purpose of this investigation is to analyse thoroughly the challenge of social agreements. This issue, very common in the commercial law area, it is been kept in our national Law without any changes for a long period of time. Nevertheless, in 2014 a reform of the Corporate Enterprises Act had place and the challenge os social agreements was one of the main important matters changed. With this reform different aspects of the have been unified and improved from the previous legislation of the social agreements. Moreover, limits have been determined in order to maintain above all the shared will of the associates which was the driving force to create the company in the first place. Thus, along this investigation proyect it is shown the modifications and improvements which have place with the reform that happen in 2014.
Gender Differences in Prescribing Antihypertensive Drugs in a Public Hospital in Alkharj
Authors: Ahmed Nehad J. , Menshawy Menshawy A. , Almalki Ziyad S. 
Published: December 2020

Introduction: Hypertension is considered one of the most significant risk factors for mortality and morbidity worldwide. There are major clinical implications for gender-specific pharmacokinetics and pharmacodynamics. It is important to know the potential gender differences in hypertension treatment and to know the prescribing trends in male and female hypertensive patients in order to optimize the treatment of hypertension.
Aim: This is a retrospective study that aims to describe the difference in prescribing antihypertensive drugs between male and female patients.
Methodology: This is a retrospective study that includes the revision of patient electronic records of outpatients with hypertension in 2018 in Alkharj.
Results: The total number of prescribed antihypertensive drugs was 1838 drugs. The calcium channel blocker was the most commonly prescribed antihypertensive class (27.86%). The study showed that there are different patterns of antihypertensive drug use among hypertensive men and women and showed that female patients are more frequently treated with diuretics and less frequently with angiotensin-converting enzyme inhibitors and angiotensin receptors blockers than male patients.
Conclusion: Stratified guidelines and policies based on gender will be appropriate if more studies show a difference in the efficacy and safety of antihypertensive drugs between male and female patients. It is important to conduct more studies about these differences.
Phytochemical, Antioxidant and Anti-Inflammatory Effects of Extracts from Ampelocissus africana (Lour) Merr (Vitaceae) Rhizomes
Authors: Kabré W. Leila Marie Esther Belem- , Ouédraogo Noufou , Coulibaly Adjaratou Compaoré- , Traoré Mariam Nebié- , Traoré Tata K. , Koala Moumouni , Belemnaba Lazare , Kini Felix B. , Kiendrebeogo Martin 
Published: December 2020

Aims: To determine the phytochemical composition and evaluate the antioxidant and anti-inflammatory properties of methanolic and aqueous extracts from Ampelocissus africana (Lour) Merr rhizomes.
Study Design: Phytochemical content and screening, in vitro antioxidant and anti-inflammatory assays.
Place and Duration of Study: Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and Laboratory of Applied Biochemistry and Chemistry (LABIOCA), University Joseph KI-ZERBO in Ouagadougou between April and August 2020.
Methodology: The antioxidant activity of both extracts of the plant was assessed using DPPH radical scavenging, ABTS+ radical cation decolorization, ferric ion reduction and lipid peroxidation inhibition in rat liver assays. The anti-inflammatory activities in vitro were measured on the ability of the extract to inhibit the activity of enzymes such as 15-lipoxygenase, phospholipase A2 (PLA2) and cyclooxygenases (COX-1 and COX-2).
Results: This study revealed that the total phenolic contents of the extracts varied from 471.79 ± 1.71 mg GAE/g to 173.88 ± 1.71 mg GAE/g for methanolic and aqueous extract respectively. The extracts were also rich in flavonoids and tannins. The methanolic extract possessed better antioxidant activity with an IC50 of 2.32 ± 0.18 µg/ml for the ABTS, 1.71 ± 0.05 µg/mL for the DPPH, a reducing power agent of 87.44 ± 0.5 mmol AAE /100 g and a percentage inhibition of lipid peroxidation of 52.21%. The methanolic and aqueous extract of A. africana has an inhibitory action on activity of lipoxygenase with IC50 values of 26.09 ± 1.83 μg/mL to 34.32 ± 1.60 μg/mL, respectively. The methanolic extract caused COX-1 inhibition of 36.07%, COX-2 inhibition of 38.31% and PLA2 inhibition of 26.9%.
Conclusion: These results showed that the methanolic and aqueous extract from the rhizomes of Ampelocissus africana possessed antioxidant power, inhibitor effect against proinflammatory enzymes.
Strategy to Construct 1,2,3‐Triazoles by K2CO3‐Mediated [4+1] Annulation Reactions of N‐Acetyl Hydrazones with Bifunctional Amino Reagents
Authors: Zhang Xiaoke , Pan Yang , Wang Haibo , Liang Chong , Ma Xiaofeng , Jiao Wei , Shao Huawu 
Published: December 2020

AbstractK2CO3‐mediated [4+1] annulation reactions of N‐acetyl hydrazones with bifunctional amino reagents are described, which provide an environmental‐friendly strategy to construct 1,2,3‐triazoles that does not employ metals, azides, organocatalysis, or oxidants. A series of substituted 1,2,3‐triazole derivatives was prepared with good yields.magnified image
A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis
Authors: Qin Yilu , Hou Yixuan , Liu Shuiqing , Zhu Pengpeng , Wan Xueying , Zhao Maojia , Peng Meixi , Zeng Huan , Li Qiao , Jin Ting , Cui Xiaojiang , Liu Manran 
Published: December 2020

AbstractCancer stem cells (CSCs) are considered the roots of cancer metastasis and recurrence (CSCs), due in part to their self‐renewal and therapy resistance properties. However, the underlying mechanisms for the regulation of CSC stemness are poorly understood. Recently, increasing evidence shows that long non‐coding RNAs (lncRNAs) are critical regulators for cancer cell function in various malignancies including breast cancer, but how lncRNAs regulate the function of breast cancer stem cells (BCSCs) remains to be determined. Herein, using lncRNA/mRNA microarray assays, a novel lncRNA (named lnc030) is identified, which is highly expressed in BCSCs in vitro and in vivo, as a pivotal regulator in maintaining BCSC stemness and promoting tumorigenesis. Mechanistically, lnc030 cooperates with poly(rC) binding protein 2(PCBP2) to stabilize squalene epoxidase (SQLE) mRNA, resulting in an increase of cholesterol synthesis. The increased cholesterol in turn actives PI3K/Akt signaling, which governs BCSC stemness. In summary, these findings demonstrate that a new, lnc030‐based mechanism for regulating cholesterol synthesis and stemness properties of BCSCs. The lnc030‐SQLE‐cholesterol synthesis pathway may serve as an effective therapeutic target for BCSC elimination and breast cancer treatment.
The residual impact of straw mulch and biochar amendments on soil physiochemical properties and yield of maize under rainfed system
Authors: Khan Ismail , Chen Taotao , Farooq Muhammad , Luan Ce , Wu Qi , wanning Dai , Xu Su , Li‐xue Wang 
Published: December 2020

AbstractGlobal warming and climate alterations have adversely affected agricultural production systems. The application of biochar can help mitigate climate change impacts and enhance the production and quality of agriculture. The field experiments were conducted during 2018 and 2019 to evaluate the effects of straw mulch (0 and 8 tons ha−1) and biochar (0, 4, 12, and 36 tons ha−1) on soil temperature, soil pH, bulk density, electric conductivity, cation exchange capacity, soil organic carbon, soil nutrient status (available P, K, NO3−, and NH4+) at various soil depth (10, 20, and 30 cm), and yield and yield‐related traits of rainfed maize (Zea mays L.). The results showed that addition of biochar regulated the soil temperature, pH, electrical conductivity, cation exchange capacity, and increased the soil organic carbon, soil nutrient status (available P, K, NO3−, and NH4+) compared to non‐biochar‐treated soils. In contrast, the higher amount of biochar (36 tons ha−1) application decreased the soil bulk density compared to control. However, the combined application of straw mulch and biochar improved the grain yield and yield contributing traits of maize. In conclusion, either straw mulch and biochar or combined straw mulch + biochar‐based soil management techniques regulate the temperature and physiochemical properties of soil. These improvements in soil properties increased the grain yield of rainfed maize and help to mitigate global warming.
Comparing cancer risk estimates using occupational record linkage approaches in male Florida firefighters
Authors: McClure Laura A. , Koru‐Sengul Tulay , Hernandez Monique N. , Caban‐Martinez Alberto J. , Kobetz Erin N. , Lee David J. 
Published: December 2020

AbstractBackgroundFirefighters have an increased risk of cancer, but variations in reported results could be due to differences in occupational case ascertainment. This study compares cancer risk estimates generated by identifying firefighters from their occupational title available in the Florida Cancer Data System (FCDS) versus identification by a linkage method between the FCDS and the Florida State Fire Marshal's Office.MethodsFlorida firefighter employment records (1972–2012; n = 109,009) were linked with FCDS data (1981–2014; ~3.3 million records), identifying 3760 primary cancers in male firefighters. Using the FCDS occupational data field we identified 1831 male cancer cases in those classified as firefighters, first‐line supervisors of firefighting and prevention workers, fire inspectors, emergency medical technicians, or paramedics. Age and calendar year‐adjusted odds ratios (aOR) and 95% confidence intervals for firefighters versus non‐firefighters were calculated for both groups.ResultsFor skin cancers the risk estimate for FCDS‐indentified firefighters was substantially lower than in the employment‐record‐linked firefighters (aOR = 1.06; 0.87–1.29 vs. 1.54; 1.37–1.73), but for endocrine system cancers it was greater (aOR = 2.36; 1.77–3.14 vs. 2.08; 1.71–2.53). Remaining cancer risk estimates were in the same direction for the two samples except for lymphoma (aOR = 1.10; 0.90–1.34 vs. 0.86; 0.75–0.99).ConclusionReliance on occupational title in cancer registry records to characterize firefighter cancer risk may result in estimates that are over‐ or underestimated depending on cancer site. The authors recommend moving toward national linkages between cancer registries and certification or other administrative records, which are a vital resource for firefighter cancer research.
(p‐(Diphenylarsino)phenyl)diphenylphosphine as a Novel Template for Heterodinuclear Complexes
Authors: Akioka Ippei , Sumida Akifumi , Urushizaki Aya , Imoto Hiroaki , Naka Kensuke 
Published: December 2020

AbstractPhosphorus and arsenic have different coordination ability to Lewis acids, though they belong to 15 group. Utilizing the difference, we designed a novel ligand, (p‐(diphenylarsino)phenyl)diphenylphosphine, in which diphenylphosphine and diphenylarsine units are combined through a p‐phenylene linker, as a template to arrange Lewis acids. The phosphorus atom exhibited superior coordination ability to the arsenic one. NMR studies revealed that BH3, AuCl, and PtCl2 were preferentially coordinated by the phosphorus atom. Sequential addition of these Lewis acids realized precise arrangement on the template ligand.
Photocatalytic Aerobic Oxidative Ring Expansion of Cyclic Ketones to Macrolactones by Cerium and Cyanoanthracene Catalysis
Authors: Du Jianbo , Yang Xiaokun , Wang Xin , An Qing , He Xu , Pan Hui , Zuo Zhiwei 
Published: December 2020

AbstractWe describe a cerium‐catalyzed aerobic oxidative ring expansion for the expedient construction of synthetically challenging macrolactones under visible‐light conditions. Cyanoanthracene has been employed as co‐catalyst to accelerate the turnover of the cerium cycle leading to a fast conversion within 20 min of irradiation. Taking advantage of the high efficiency and operationally simple conditions, a collection of over 100 macrolactones equipped with ring systems ranging from 9‐ to 19‐membered macrocycles have been prepared from simple building blocks. Moreover, the enabling potential of this strategy to simplify the generation of molecular complexity has been demonstrated through the concise synthesis of sonnerlactone.
A Dual Role Reductase from Phytosterols Catabolism Enables the Efficient Production of Valuable Steroid Precursors
Authors: Peng Haidong , Wang Yaya , Jiang Kai , Chen Xinru , Zhang Wenlu , Zhang Yanan , Deng Zixin , Qu Xudong 
Published: December 2020

Abstract4‐Androstenedione (4‐AD) and progesterone (PG) are two of the most important precursors for synthesis of steroid drugs, however their current manufacturing processes suffer from low efficiency and severe environmental issues. In this study, we decipher a dual‐role reductase (mnOpccR) in the phytosterols catabolism, which engages in two different metabolic branches to produce the key intermediate 20‐hydroxymethyl pregn‐4‐ene‐3‐one (4‐HBC) through a 4‐e reduction of 3‐oxo‐4‐pregnene‐20‐carboxyl‐CoA (3‐OPC‐CoA) and 2‐e reduction of 3‐oxo‐4‐pregnene‐20‐carboxyl aldehyde (3‐OPA), respectively. Inactivation or overexpression of mnOpccR in the Mycobacterium neoaurum can achieve exclusive production of either 4‐AD or 4‐HBC from phytosterols. By utilizing a two‐step synthesis, 4‐HBC can be efficiently converted into PG in a scalable manner (100 gram scale). This study deciphers a pivotal biosynthetic mechanism of phytosterol catabolism and provides very efficient production routes of 4‐AD and PG.
Phosphonates of Vegetable Oils—Characterization as Lubricants
Authors: Biresaw Girma , Bantchev Grigor B. , Harry‐O'Kuru Rogers E. 
Published: December 2020

AbstractDialkyl phosphonates of vegetable oils were synthesized by reacting soybean (Soy) and high oleic sunflower (HOSuO) oils with dialkyl phosphites. Dimethyl, diethyl, and di‐n‐butyl phosphites were used in the synthesis and the resulting phosphonates were obtained in good yields and thoroughly characterized. All six phosphonates displayed poor solubility in polyalphaolefin‐6; and four displayed adequate solubility (> 20% w/w) in HOSuO. Evaluation as anti‐wear (AW) additives in HOSuO base oil blends showed the biobased phosphonates have similar coefficient of friction and similar or better wear scar diameter than zinc dialkyl dithio phosphates (ZDDP). It is concluded that vegetable oil phosphonates provide a promising biobased alternative to ZDDP and other commercial petroleum‐based AW additives currently used in lubricant formulations.
Metastasis to the finger of oral floor squamous cell carcinoma: A case report
Authors: Isomura Emiko Tanaka , Hamaguchi Munehiro , Nishimura Nao , Ushimura Ayako , Namikawa Mari 
Published: December 2020

AbstractWhen cetuximab is used, diagnosing finger metastasis can be difficult due to the side effects of paronychia and color changes of nails. Finger metastasis may be a marker of multiple metastasis; therefore, it can lead to a poor prognosis.
An acquired factor V inhibitor induced uncontrolled bleeding in a postsurgery patient
Authors: Bruna Riccardo , Moia Riccardo , Valpreda Alessandra , Dosio Enrico , Rolla Roberta , Federici Augusto , Dianzani Umberto , Gaidano Gianluca , Patriarca Andrea 
Published: December 2020

AbstractThis case report highlights the challenges in controlling bleeding and correcting coagulation tests through the use of bypassing agents in patients with FV inhibitors.
Explosionsprävention durch Funkendetektion
Authors: Krone Volker 
Published: December 2020

AbstractEgal ob in Mühlen, Holzfabriken oder Betrieben der chemischen Industrie — in Branchen, in denen Schüttgut verarbeitet wird, ist die Gefahr einer Explosion omnipräsent. Die Funkenerkennung und ‐löschung ist eine komplexe Methode, um Brände und Explosionen
Sequencing of novel agents in relapsed/refractory B‐cell acute lymphoblastic leukemia: Blinatumomab and inotuzumab ozogamicin may have comparable efficacy as first or second novel agent therapy in relapsed/refractory acute lymphoblastic leukemia
Authors: Badar Talha , Szabo Aniko , Dinner Shira , Liedtke Michaela , Burkart Madelyn , Shallis Rory M. , Yurkiewicz Ilana R. , Kuo Eric , Khan Muhammad Ali , Balasubramanian Suresh , Yang Jay , Hefazi Mehrdad , Podoltsev Nikolai , Patel Anand , Curran Emily , Wang Amy , Arslan Shukaib , Aldoss Ibrahim , Siebenaller Caitlin , Mattison Ryan J. , Litzow Mark R. , Wadleigh Martha , Advani Anjali S. , Atallah Ehab 
Published: December 2020

BackgroundThe availability of novel agents (NAs), including blinatumomab and inotuzumab ozogamicin (InO), has improved the outcomes of patients with relapsed/refractory (RR) B‐cell acute lymphoblastic leukemia (ALL). Because of the relative effectiveness, it is often a challenge for clinicians to determine how to best sequence these NAs with respect to efficacy and toxicity.MethodsIn this multicenter, retrospective study of patients with RR ALL treated with blinatumomab, InO, or both, their efficacy as a first or second NA was compared.ResultsAmong 276 patients, 221 and 55 received blinatumomab and InO, respectively, as a first NA therapy. The complete remission (CR)/complete remission with incomplete count recovery (CRi) rate was 65% and 67% for the blinatumomab and InO groups, respectively (P = .73). The rate of treatment discontinuation due to adverse events was 4% and 7% in the blinatumomab and InO groups, respectively. Ninety‐two patients (43%) in the blinatumomab group and 13 patients (29%) in the InO group proceeded with allogeneic hematopoietic stem cell transplantation. The median overall survival (OS) was 15 and 11.6 months in the blinatumomab and InO groups, respectively. A subset analysis was performed for 61 patients who received both NAs (blinatumomab and then InO [n = 40] or InO and then blinatumomab [n = 21]). The CR/CRi rate was 58% for patients who received InO as the second NA and 52% for patients who received blinatumomab as the second NA. The median OS was 10.5 for patients who received InO as the second NA and 5.9 months for patients who received blinatumomab as the second NA (P = .09).ConclusionsAlthough the limited power of this study to detect a significant difference between subgroups is acknowledged, the data suggest that blinatumomab and InO may have comparable efficacy as a first or second NA therapy in RR ALL.
Social media as stakeholder engagement tool: CSR communication failure in the oil and gas sector
Authors: Pizzi Simone , Moggi Sara , Caputo Fabio , Rosato Pierfelice 
Published: December 2020

AbstractThis article explores to what extent oil and gas companies use social media to engage with stakeholders on Corporate Social Responsibility (CSR) strategies. Drawing from the analysis of oil and gas megaproject facing the local community's protects, the research aims to highlight the level of stakeholder interaction on CSR's actions disclosed by social media. The study considers the Trans Adriatic Pipeline experience and the degree of interactions between the company and its stakeholders. According to Carroll's pyramid, the contents of Tweets were analyzed with the assistance of the statistics software program “TwitteR” and classified by their content. The analysis of the engagement practices on Twitter reveals that legitimization is influenced by the CSR contents proposed by the firms and the phase of megaproject development. Results suggest that social media communication does not always respond to stakeholder claims that should be periodically monitored through adequate stakeholder engagement tools.