bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antenatal predictors of intestinal pathologies in fetal bowel dilatation
Authors: Huang Lan , Huang Danping , Wang Hongying , Zhang Xiangxiang , Yu Hongkui , Yang Pan 
Published: February 2020

AimFetal bowel dilatation (FBD) in the late trimester of pregnancy can be related with varies of prognosis. Our aims were to obtain antenatal factors that might have relevance for the distinct prognosis with FBD.MethodsSeven features of 68 pregnancies presented with FBD were assessed. The best cut‐off value to predict intestinal outcomes was selected using receiver‐operating characteristics curves, and the effective variables were included into a logistic regression model.ResultsThe best cut‐off valves to predict intestinal pathologies were 14.5 mm of fetus dilated loop and 37.7 weeks of gestational age at delivery, respectively. The congenital gastrointestinal tract anomalies included 24 cases (92.3%) of intestine atresia, 1 case (3.85%) of small intestine volvulus and 1 case (3.85%) of midgut malrotation.ConclusionFetal dilated loops and gestational age at delivery are both an independent risk factor for predicting intestinal pathologies of newborns, which should arouse high attention.
Combined Effects of Temperature, Irradiance, and pH on Teleaulax amphioxeia (Cryptophyceae) Physiology and Feeding Ratio For Its Predator Mesodinium rubrum (Ciliophora)1
Authors: Gaillard Sylvain , Charrier Aurélie , Malo Florent , Carpentier Liliane , Bougaran Gaël , Hégaret Hélène , Réveillon Damien , Hess Philipp , Séchet Véronique 
Published: February 2020

The cryptophyte Teleaulax amphioxeia is a source of plastids for the ciliate Mesodinium rubrum and both organisms are members of the trophic chain of several species of Dinophysis. It is important to better understand the ecology of organisms at the first trophic levels before assessing the impact of principal factors of global change on Dinophysis spp. Therefore, combined effects of temperature, irradiance, and pH on growth rate, photosynthetic activity, and pigment content of a temperate strain of T. amphioxeia were studied using a full factorial design (central composite design 23*) in 17 individually controlled bioreactors. The derived model predicted an optimal growth rate of T. amphioxeia at a light intensity of 400 μmol photons · m−2 · s−1, more acidic pH (7.6) than the current average and a temperature of 17.6°C. An interaction between temperature and irradiance on growth was also found, while pH did not have any significant effect. Subsequently, to investigate potential impacts of prey quality and quantity on the physiology of the predator, M. rubrum was fed two separate prey: predator ratios with cultures of T. amphioxeia previously acclimated at two different light intensities (100 and 400 μmol photons · m−2 s−1). M. rubrum growth appeared to be significantly dependent on prey quantity while effect of prey quality was not observed. This multi‐parametric study indicated a high potential for a significant increase of T. amphioxeia in future climate conditions but to what extent this would lead to increased occurrences of Mesodinium spp. and Dinophysis spp. should be further investigated.
Can rapport building strategies, age, and question type influence preschoolers’ disclosures of adult wrongdoing?
Authors: Magnusson Mikaela , Ernberg Emelie , Landström Sara , Joleby Malin , Akehurst Lucy 
Published: February 2020

In the present experiment, we examined preschoolers’ disclosures of a secret as a function of rapport building strategies used in Scandinavian field settings (verbal rapport building vs. prop rapport building), age in months (33–75 months) and question type (open‐ended free recall invitation vs. suggestive questions). Fifty‐three preschoolers (M = 60.5 months old, SD = 11.4) witnessed a researcher break a toy and were asked to keep the toy breakage a secret. The children were thereafter interviewed about the incident. Overall, 18.9% of the children disclosed the secret after an open‐ended free recall invitation. The disclosure rate rose to 83% after the final phase of the interviews when questions containing suggestive details were asked of the children. Notably, we did not observe any significant effects as a function of manipulating rapport building strategy. A linear regression model showed that child age (in months) significantly predicted the amount of reported details, with younger preschoolers reporting fewer details compared to older preschoolers. Age also predicted the amount of correct details, but not the amount of incorrect details. No age differences were found with regard to children’s disclosure tendencies or proportion of central details about the secret. Methodological limitations and practical implications will be addressed.
microRNA‐143‐3p regulates odontogenic differentiation of human dental pulp stem cells through regulation of the osteoprotegerin–RANK ligand pathway by targeting RANK
Authors: Yang Changwei , Jia Ru , Zuo Qiliang , Zheng Yanfen , Wu Qianju , Luo Bizhu , Lin Pingting , Yin Lu 
Published: February 2020

New Findings
What is the central question of this study?
What is the role of miR‐143‐3p during human dental pulp stem cell (hDPSC) differentiation.

What is the main finding and its importance?
miR‐143‐3p negatively regulates receptor activator of nuclear factor‐κB (RANK). RANK ligand (RANKL) binds to RANK and stimulates the development of osteoclasts. Osteoprotegerin (OPG) inhibits the interaction between RANK and RANKL. The OPG–RANKL signalling pathway regulates odontogenic differentiation of hDPSCs.

AbstractHuman dental pulp stem cells (hDPSCs) are capable of differentiating into odontoblast‐like cells, which secrete reparative dentin after injury, in which the role of microRNA‐143‐3p (miR‐143‐3p) has been identified. Therefore, we investigated the mechanism by which miR‐143‐3p influences odontoblastic differentiation of hDPSCs. The relationship between miR‐143‐3p and receptor activator of nuclear factor‐κB (RANK) was initially identified by bioinformatics prediction and further verified by dual luciferase reporter gene assay. Gain‐ and loss‐of‐function analysis with miR‐143‐3p mimic and miR‐143‐3p inhibitor was subsequently conducted. Dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), alkaline phosphatase (ALP), osteocalcin (OCN) and osteopontin (OPN) mRNA levels were then evaluated by RT‐qPCR. Osteoprotegerin (OPG), RANK ligand (RANKL), nuclear factor‐κB (NF‐κB) p65 protein levels and the extent of NF‐κB p65 phosphorylation were examined by western blot analysis. Alizarin red staining was performed to assess the mineralization of hDPSCs. Cell apoptosis and cell cycle distribution were determined using flow cytometry. During odontoblastic differentiation of hDPSC, miR‐143‐3p had high expression, but RANK expression was low. miR‐143‐3p was found to target RANK, and its inhibition enhanced mineralization and hDPSC apoptosis, while blocking cell cycle entry. At the same time, miR‐143‐3p inhibition elevated the extent of NF‐κB p65 phosphorylation, as well as the expression of RANK, RANKL, DSPP, BSP, ALP, OCN and OPN, while decreasing the OPG level. Silencing RANK had opposite effects on these markers. miR‐143‐3p regulates odontoblastic differentiation of hDPSCs via the OPG–RANKL pathway that targets RANK. The elucidation of the mechanisms of odontogenic differentiation of hDPSCs may contribute to the development of effective dental pulp repair therapies for the clinical setting.
Affective Feelings and Perceived Exertion During a 10-km Time Trial and Head-to-Head Running Race
Authors: do Carmo Everton C. , Barroso Renato , Renfree Andrew , da Silva Natalia R. , Gil Saulo , Tricoli Valmor 
Published: February 2020

Purpose: To verify the affective feelings (AFs) and rating of perceived exertion (RPE) responses during a 10-km competitive head-to-head (HTH) running race and compare them with a time-trial (TT) running race. Methods: Fourteen male runners completed 2 × 10-km runs (TT and HTH) on different days. Speed, RPE, and AF were measured every 400 m. For pacing analysis, races were divided into the following 4 stages: first 400 m (F400), 401–5000 m (M1), 5001–9600 m (M2), and the last 400 m (final sprint). Results: Improvement of performance was observed (39:32 [02:41] min:s vs 40:28 [02:55] min:s; P = .03; effect size = −0.32) in HTH compared with TT. There were no differences in either pacing strategy or RPE between conditions. AFs were higher during the HTH, being different in M2 compared with TT (2.09 [1.81] vs 0.22 [2.25]; P = .02; effect size = 0.84). Conclusions: AFs are directly influenced by the presence of opponents during an HTH race, and a more positive AF could be involved in the dissociation between RPE and running speed and, consequently, the overall race performance.
Platelet RNA as Pan-Tumor Biomarker for Cancer Detection
Authors: Wurdinger Thomas , In ‘t Veld Sjors G.J.G. , Best Myron G. 
Published: February 2020

Abstract
Blood-based liquid biopsies are considered a screening approach for early cancer detection. Sequencing technologies enable in-depth analyses of nucleic acids, including mutant cell-free (cf) DNA in the plasma. However, in the blood of patients with early-stage cancer the detection level of mutant cfDNA is relatively low, and complicated by the natural presence of noncancer cfDNA mutants attributed to aging-related processes. Consequently, analysis of methylated cfDNA patterns and alternative approaches such as tumor-educated platelets are gaining traction for the detection of early-stage tumors. Here, we dissect the use of platelet RNA as a potential biomarker for the development of early-stage, pan-cancer blood tests.
Association Between Palliative Care and Death at Home in Adults With Heart Failure
Authors: Quinn Kieran L. , Hsu Amy T. , Smith Glenys , Stall Nathan , Detsky Allan S. , Kavalieratos Dio , Lee Douglas S. , Bell Chaim M. , Tanuseputro Peter 
Published: February 2020

Background
Palliative care is associated with improved symptom control and quality of life in people with heart failure. There is conflicting evidence as to whether it is associated with a greater likelihood of death at home in this population. The objective of this study was to describe the delivery of newly initiated palliative care services in adults who die with heart failure and measure the association between receipt of palliative care and death at home compared with those who did not receive palliative care.

Methods and Results

We performed a population‐based cohort study using linked health administrative data in Ontario, Canada of 74 986 community‐dwelling adults with heart failure who died between 2010 and 2015. Seventy‐five percent of community‐dwelling adults with heart failure died in a hospital. Patients who received any palliative care were twice as likely to die at home compared with those who did not receive it (adjusted odds ratio 2.12 [95%
CI
, 2.03–2.20];
P
<0.01). Delivery of home‐based palliative care had a higher association with death at home (adjusted odds ratio 11.88 [95%
CI
, 9.34–15.11];
P
<0.01), as did delivery during transitions of care between inpatient and outpatient care settings (adjusted odds ratio 8.12 [95%
CI
, 6.41–10.27];
P
<0.01). Palliative care was most commonly initiated late in the course of a person's disease (≤30 days before death, 45.2% of subjects) and led by nonspecialist palliative care physicians 61% of the time.

Conclusions
Most adults with heart failure die in a hospital. Providing palliative care near the end‐of‐life was associated with an increased likelihood of dying at home. These findings suggest that scaling existing palliative care programs to increase access may improve end‐of‐life care in people dying with chronic noncancer illness.
Incidence of Acute Kidney Injury After Computed Tomography Angiography±Computed Tomography Perfusion Followed by Thrombectomy in Patients With Stroke Using a Postprocedural Hydration Protocol
Authors: Weber Ralph , van Hal Robert , Stracke Paul , Hadisurya Jeffrie , Nordmeyer Hannes , Chapot René 
Published: February 2020

Background
The risk of contrast‐induced acute kidney injury (AKI) in patients with stroke receiving both computed tomography (CT) angiography and mechanical thrombectomy has been investigated only in small case series. No studies have investigated whether additional CT perfusion or chronic kidney disease (CKD) are associated with higher rates of AKI.

Methods and Results

Retrospective analysis of the AKI incidence in 1089 consecutive patients receiving CT angiography and mechanical thrombectomy from 2015 to 2017 and in subgroups with CKD (n=99) and CT perfusion (n=104) was performed. Patients received a standardized hydration protocol. Data on kidney function after mechanical thrombectomy were available in 1017 patients. A total of 59 (5.8%) patients developed AKI, and only 4 (6.8%) patients needed hemodialysis, all with known CKD. Patients with AKI significantly more often had known CKD (20.3% versus 8.4%,
P
=0.002), diabetes mellitus (33.9% versus 20.9%,
P
=0.018), and tandem occlusion (32.2% versus 16.2%,
P
=0.003) and a significantly higher in‐hospital mortality (20.3% versus 7.0%,
P
<0.001) compared with patients without AKI. However, there were no significant independent predictors for AKI in multivariable logistic regression analysis. Sex (odds ratio [OR], 2.03; 95% CI, 1.17–3.52 [
P
=0.012]), higher National Institutes of Health Stroke Scale (OR, 1.10; 95% CI, 1.05–1.14 [
P
<0.001]), AKI (OR, 3.52; 95% CI, 1.63–7.64 [
P
=0.001]), diuretic use (OR, 1.80; 95% CI, 1.02–3.19), futile or incomplete recanalization (OR, 0.19; 95% CI, 0.09–0.40 [
P
<0.001]), and total volume of contrast agent volume (OR, 1.007; 95% CI, 1.002–1.011 [
P
=0.004]) were independently associated with in‐hospital death. Two thirds of the patients with AKI died of severe brain damage and not AKI itself.

Conclusions
Post‐contrast AKI rarely occurs in patients with stroke receiving a contrast agent for CT angiography/CT perfusion and subsequent mechanical thrombectomy. Patients with known CKD had higher rates of AKI and only these patients needed hemodialysis, but CKD was not independently associated with AKI or in‐hospital mortality.
Number-related Brain Potentials Are Differentially Affected by Mapping Novel Symbols on Small versus Large Quantities in a Number Learning Task
Authors: van den Berg Fabian C. G. , de Weerd Peter , Jonkman Lisa M. 
Published: February 2020

Abstract
The nature of the mapping process that imbues number symbols with their numerical meaning—known as the “symbol-grounding process”—remains poorly understood and the topic of much debate. The aim of this study was to enhance insight into how the nonsymbolic–symbolic number mapping process and its neurocognitive correlates might differ between small (1–4; subitizing range) and larger (6–9) numerical ranges. Hereto, 22 young adults performed a learning task in which novel symbols acquired numerical meaning by mapping them onto nonsymbolic magnitudes presented as dot arrays (range 1–9). Learning-dependent changes in accuracy and RT provided evidence for successful novel symbol quantity mapping in the subitizing (1–4) range only. Corroborating these behavioral results, the number processing related P2p component was only modulated by the learning/mapping of symbols representing small numbers 1–4. The symbolic N1 amplitude increased with learning independent of symbolic numerical range but dependent on the set size of the preceding dot array; it only occurred when mapping on one to four item dot arrays that allow for quick retrieval of a numeric value, on the basis of which, with learning, one could predict the upcoming symbol causing perceptual expectancy violation when observing a different symbol. These combined results suggest that exact nonsymbolic–symbolic mapping is only successful for small quantities 1–4 from which one can readily extract cardinality. Furthermore, we suggest that the P2p reflects the processing stage of first access to or retrieval of numeric codes and might in future studies be used as a neural correlate of nonsymbolic–symbolic mapping/symbol learning.
Media
Authors: Callison Candis 
Published: February 2020

In 1968, two years before the first Earth Day, the Apollo 8 mission captured Earthrise, the first color image of earth. Four years later, the Apollo 17 mission took the now iconic image, The Blue Marble, the first to encompass the whole Earth. These photographs have become the most recognizable images of our planet, broadcast across the globe through our media, marking the beginnings of a shift in our conceptualization of the planet. In this chapter, Callison charts the relationship between the media and the environment, highlighting the roles played by different media (television, radio, newspapers, etc.) in the development of new environmental policies, and exploring the different ways in which climate change, and the Earth, has been represented – for example, in its 1989 issue, Time magazine replaced its ‘Person of the Year’ with our ‘Planet of the Year’, beneath the headline, ‘Endangered Earth’. However, in the 1990s, media outlets began to shift their coverage away from environmental issues and science topics more generally, with some national media outlets questioning the legitimacy of climate change, despite progressively more urgent scientific reports being published. In this chapter, Callison examines media coverage of climate change through the last fifty years, addressing, among other themes, the slippery character of climate change as a news story, and the failure of media coverage to represent diversity in human experience and relations. In 2020, our myriad of handheld devices connect us globally in ways that weren’t imaginable fifty years ago; yet, despite this digital infrastructure, how connected we feel to each other, and how informed we are, is still equivocal.
Synergy of Satellite- and Ground-Based Observations for Continuous Monitoring of Atmospheric Stability, Liquid Water Path, and Integrated Water Vapor: Theoretical Evaluations Using Reanalysis and Neural Networks
Authors: Toporov Maria , Löhnert Ulrich 
Published: February 2020

AbstractAtmospheric stability plays an essential role in the evolution of weather events. While the upper troposphere is sampled by satellite sensors, and in situ sensors measure the atmospheric state close to the surface, only sporadic information from radiosondes or aircraft observations is available in the planetary boundary layer. Ground-based remote sensing offers the possibility to continuously and automatically monitor the atmospheric state in the boundary layer. Microwave radiometers (MWR) provide temporally resolved temperature and humidity profiles in the boundary layer and accurate values of integrated water vapor and liquid water path, and the differential absorption lidar (DIAL) measures humidity profiles with high vertical and temporal resolution up to 3000-m height. Both instruments have the potential to complement satellite observations by additional information from the lowest atmospheric layers, particularly under cloudy conditions. This study presents a neural network retrieval for stability indices, integrated water vapor, and liquid water path from simulated satellite- and ground-based measurements based on the COSMO regional reanalysis (COSMO-REA2). Focusing on the temporal resolution, the satellite-based instruments considered in the study are the currently operational Spinning Enhanced Visible and Infrared Imager (SEVIRI) and the future Infrared Sounder (IRS), both in geostationary orbit. Relative to the retrieval based on satellite observations, the additional ground-based MWR/DIAL measurements provide valuable improvements not only in the presence of clouds, which represent a limiting factor for infrared SEVIRI/IRS, but also under clear-sky conditions. The root-mean-square error for convective available potential energy, for instance, is reduced by 24% if IRS observations are complemented by ground-based MWR measurements.
What drives social responsibility commitment? An empirical analysis of public enterprises in South Korea
Authors: Kim Seok Eun , Kim You Hyun 
Published: February 2020

This study examines factors affecting the social responsibility commitment of public enterprises in South Korea. A panel regression analysis of 70 public enterprises found that the social responsibility commitment appears to increase when organizations are financially healthy and strategically oriented. However, the relationship between ethical behavior and social responsibility was negligible. These results have three management implications: first, the conventional social responsibility assumption that economic efficiency neutralizes societal goals is not necessarily true; second, public enterprises with commitments to strategic social responsibility appear to be more socially responsible than those without commitments to strategic social responsibility; and, third, ethical behavior may not be a reliable indicator of the social responsibility commitment, especially if it is mandated by the government. Points for practitioners Public enterprises have increasingly been under pressure to share the burden of social and economic problems in society. However, many practitioners still have little knowledge about under what conditions they can do good and benefit society. The results of this article suggest that profit making embodied in ethical rules and a dedicated governance structure to communicate with stakeholders create conditions that are more conducive to doing socially responsible activity.
Correlation between vaspin and PANSS scores in schizophrenia patients with obesity
Authors: Ertekin Hülya , Uysal Sema , Aydın Memduha , İlhan Bilge , Ertekin Yusuf Haydar 
Published: February 2020

Objective Metabolic abnormalities such as diabetes, dyslipidemia, abdominal obesity, metabolic syndrome, and abnormal levels of plasma adipokines have been observed in patients with schizophrenia. This study aimed to investigate the differences and correlations of plasma vaspin levels with metabolic parameters in patients with schizophrenia and to compare with healthy controls. Method We measured plasma levels of vaspin and metabolic parameters of 100 patients with schizophrenia and 95 healthy controls. Patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale (PANSS) and The Global Assessment of Functioning. Results Mean levels of body mass index, waist circumference, triglyceride, and low-density lipoprotein cholesterol of the patients were statistically higher than those of the healthy controls (p = 0.002, p < 0.001, p = 0.03, and p = 0.002, respectively). Plasma levels of vaspin were 0.96 ± 0.73 ng/ml in patients with schizophrenia and 0.29 ± 0.15 ng/ml in the healthy controls (p < 0.001). Plasma vaspin levels were statistically higher in patients with schizophrenia than healthy controls both in groups with and without metabolic syndrome and obesity (p < 0.001). Plasma vaspin levels showed a positive correlation with triglyceride in patients with schizophrenia (r = 0.26, p = 0.007). There were positive correlations between vaspin and PANSS scores in schizophrenia patients with obesity (PANSS Positive: r = 0.42, p = 0.01; PANSS Negative: r = 0.42, p = 0.01; PANSS General: r = 0.43, p = 0.01; PANSS Total: r = 0.47, p = 0.006). Conclusions Our study showed a significant relationship and positive correlation between vaspin and PANSS scores in schizophrenia patients with obesity. Vaspin may play an important role in the metabolic processes of patients with schizophrenia.