bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARKERS FOR PREDICTING THE DEVELOPMENT OF CRITICAL CONDITION IN CHILDREN WITH RESPIRATORY DISEASES UNDER INTENSIVE THERAPY
Authors: Fesenko M.Ye. , Pokhylko V.I. , Tsvirenko S.M. , Ziuzina L.S. , Kaliuzhka O.O. 
Published: April 2020

Introduction. The clinical course of respiratory diseases is often accompanied with the impairment of the nervous system, it makes up a large proportion in the clinical picture of diseases, and often leads to long-term adverse effects. The purpose of the study is to elaborate the diagnostic algorithm for predicting the course of diseases in children with respiratory pathology during the intensive care based on the thorough study of clinical and anamnestic predictors. Subjects and methodology. The study included 132 children aged from 1 day to 1 year with various pathologies during intensive care. The children were divided into 6 groups: I group included 87 patients with acute respiratory viral infection (ARVI), pneumonia; II group included 21 children with ARVI, stenosis of II-III degree, III group involved 10 children with hypoxic-ischemic encephalopathy. There was a group of children supported with artificial lung ventilation (14), who make up IV group; 20 children died. The control group consisted of 25 healthy children aged under 1 year old. We carried out clinical, bacteriological, immunological examination and statistical processing of findings obtained. Results. When assessing the cases of the clinical course in children up to 1 year, who needed intensive care to mitigate the symptoms of acute respiratory failure of II-III degree, we have found out that except of aggravating factors in the ante-, intra- and postnatal period, there are the number of pathological change detected by neurosonography, which are of unfavourable predictive value: 29.5% of children had subependymal haemorrhages; 10.3%, of children had intraventricular haemorrhages, 9% of children had periventricular haemorrhages. Infants with acute respiratory failure III degree who needed artificial lung ventilation (50% of them were premature) were born to mothers with a pathologic pregnancy and childbirth. Among children who were in the intensive care unit, the general mortality was 15.2%. The causes of death of newborns included asphyxia (80%), respiratory disorder syndrome III degree (10%), hypoxic-ischemic encephalopathy (10%). In the long-term period, the main cause of death was pneumonia, complicated by acute respiratory failure III degree, brain oedema. Conclusion. Applying of the markers to prevent and reverse the development of infants’ critical condition promotes to the reduction of morbidity, disability and mortality of children.
PREDICTION OF MULTIPLE SCLEROSIS COURSE: RESULTS OF PROSPECTIVE STUDY
Authors: Shulga O.D. 
Published: April 2020

Background: The course of multiple sclerosis is variable and unpredictable. Despite considerable efforts and research over the decades, one of the major challenges for both neurologists and patients is still to determine the prognosis of multiple sclerosis as well as the factors and markers affecting its progression. Prospective studies can partially contribute to assessment of the factors predetermining the prognosis of the course of multiple sclerosis.
Objective: To evaluate the factors affecting the course of multiple sclerosis according to a 5-year prospective dynamic observation.
Materials and methods: 175 patients with multiple sclerosis were examined over a 5-year follow-up period. The methodology employed was as follows: statistical analysis by using Microsoft Excel for Windows and SPSS; standard descriptive statistics; calculation of Pearson's chi-square for categorical analysis; single-factor analysis of variance. The magnitude and directivity of the correlation dependence were estimated using the Spearman non-parametric correlation coefficient.
Results: 175 patients with multiple sclerosis (123 women and 52 men) were examined over a 5-year follow-up period. Mean age of patients at the onset of multiple sclerosis was 28.46 ± 9.13 years; mean age at the time of diagnosis of the disease was 31.77 ± 9.28 years; the mean length of the disease was 15.48 ± 7.69 years prior the start of the observation. At the time of the patients’ status assessment in 2013, the Expanded Disability Status Scale value was 3.83 ± 1.68 scores and 4.21 ± 1.83 scores in 5 years. The degree of functional disability according to the Expanded Disability Status Scale baseline was statistically significant (p = 0.02). A single-factor analysis of variance showed that sex (p <0.007) was of the highest significance for the degree of difference by the Expanded Disability Status Scale.
Conclusions: According to results obtained, we can suggest the most influential factor for a patient's disability due to multiple sclerosis is sex. Men may develop multiple sclerosis at younger age, the disease in men progresses faster, thus, the degree of functional disability is higher compared with women.
USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS
Authors: Brodetskyi I. S. , Malanchuk V.A. , Dosenko V. E 
Published: April 2020

Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood. Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time.
Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue).
Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.
STEREOMORPHOLOGY: HISTORY AND PROSPECTS OF ITS DEVELOPMENT FOR THE THEORY AND PRACTICE OF MEDICINE
Authors: Sherstiuk O.O. , Svintsytska N.L. , Ustenko R.L. , Piliuhin A.V. , Katsenko A.L. , Lytovka V.V. 
Published: April 2020

The article shows that not only the health of the nation, but also the future of the peoples throughout the world and the future of the planet itself depends on the development of science and the quality of professional training of those providing the modern scientific process. The article highlights the stages of scientific anatomy, the results and prospects of its development. The goals, objectives, methods and results of our own research are identified on the basis of the stereomorphological method for studying hollow and parenchymal internal organs and glands. The article presents a unique technique that enables to obtain a three-dimensional view of the vessels of the human body, contributing to the spatial perception of the architectonics of the extra- and intraorgan blood channel, the injection-corrosion method, developed by the Dutch scientist F. Ruysch. It has been noted that the originality of the museum of the Department of Human Anatomy, Ukrainian Medical Dental Academy, is in its rich collection of injection and corrosion preparations of the internal organs of humans and animals. This classic technique, taking into account individual modifications, enables to get an accurate high-quality volumetric copy of the bloodstream of the internal organ or casts of the walls of a hollow organ, suitable for further morphological studies. Using the example of injection-corrosive preparations of the bloodstream of the human stomach, the features of its stereo-angioarchitectonics were investigated.
The article highlights the methodology for stereological study of the prostate, large and small salivary and lacrimal glands, used by the researchers of the Department of Human Anatomy, Ukrainian Medical Dental Academy. In particular, the results of three-dimensional plastic reconstruction have been described using the example of human epithelial structures of the prostate gland and small salivary, lacrimal glands.
PSEUDOMONAS AERUGINOSA INFECTION: MODERN APPROACHES TO MANAGEMENT OF THE MOST SIGNIFICANT CLINICAL FORMS OF PATHOLOGY
Authors: Poda O.A. 
Published: April 2020

Introduction. At present, antimicrobial therapy of ventilator-associated pneumonia and bacteremia caused by Pseudomonas aeruginosa is an urgent problem due to the high prevalence of microbial multiresistant strains and their ability to develop resistance to new antibacterial drugs.
Materials and methods. The analysis and generalization of the results of scientific studies highlighted in fundamental medical journals related to the treatment of ventilator-associated pneumonia and bacteremia caused by Pseudomonas infection are carried out.
Results. The main points in the modern approach to the effective treatment of ventilator-associated pneumonia and bacteremia caused by Pseudomonas aeruginosa include the correct empirical choice of the starting antibacterial agent in accordance with the local epidemiology of the medical setting, timely beginning of the treatment, options to combine drugs with a tendency to de-escalation to monotherapy. It is also important to choose the optimal drug in terms of its pharmacological parameters and a clear definition of the optimal therapeutic dosage. The article describes the main groups of drugs currently used in the treatment of the main clinical forms of Pseudomonas aeruginosa. Nowadays, it is recommended to combine therapy for pseudomonas ventilator-associated pneumonia and bacteremia with antipseudomonas penicillins or cephalosporins or carbapenems plus fluoroquinolones or aminoglycosides or colistin with phosphomycin.
Conclusions. Despite the elaboration of the modern approaches to the antimicrobial therapy of infections caused by Pseudomonas aeruginosa, this issue is still debatable and requires further study.
ETHNIC AND AGE-RELATED PECULIARTIES OF LIPID PEROXIDATION AND ANTIOXIDATIVE PROTECTION
Authors: Тkachenko Е.V. , Sokolenko V.N. , Mamazhonov А. , Medved L.N. , Mamadaliyev I. 
Published: April 2020

The relevance of this research is determined by a number of factors including Chernobyl tragedy, enforced usage of computer technologies and telecommunication, environmental problems, unhealthy diet poor in poor in vegetables and fruits. This promotes the condition for increased free radical production by the body and antioxidant system emaciation. Alzheimer’s and Parkinson’s diseases, lateral amyotrophic sclerosis and cataract, stroke, brain and spine traumatic injuries have been reported as rapidly growing worldwide. Less common diseases with ethio-pathogenetic mechanisms mentioned above include peroxisomal biogenesis disorders (X-linked adrenoleukodystrophy, Zellweger syndrome), Friedreich ataxia, Niemann-Pick diseases, neurodegeneration accompanied with brain iron accumulation, infantile neuroaxonal dystrophy, ferritinopathy, aceruloplasminemia. Intensive production of free oxygen species underlies the emergence of the diseases, therefore studying their ethiology, pathogenesis, clinical courses and the approaches in their early detection, treatment and prevention is one of the priority directions for genetics, biology, theoretical and applied medicine in order to determine important ethnic and age-related differences. This is of quite significance as many diseases known before as age-related now are affecting more and more of young population. Some diseases are traditionally more prevalent in some populations identified as races due to their common ancestry. It also includes altered prevalence and patterns in different ethnic groups. But nowadays the population of many countries is become more and more ethnically mixed. This is critical in diagnosing and managing some diseases as cardiovascular diseases, some autism forms with epilepsy, ischemic-hypoxic encephalopathy in children. The authors highlight lately determined mechanisms of the impairment in pro-oxidative-antioxidative status as well as some modern medicines and approaches for the correction for some pathological conditions.
ANTIOXIDANT POTENTIAL OF ADEMETIONINE IN GENTAMICINE NEPHROPATHY PROGRESSION
Authors: Drachuk V.M. , Zamorskiy I. I. , Horoshko O. M. 
Published: April 2020

Acute kidney injury has been globally considered as a serious medical issue. Its incidence rate is increasing over the years despite the introduction of new therapies, the cause of which is often a side effect to drugs, or due to the impact of toxins, trauma. Nephrotoxicity is one of the most important side effects of aminoglycoside antibiotics, and on gentamicin, in particular. Despite rigorous patient monitoring, this type of nephrotoxicity appears in 10–30% of therapeutic courses. Therefore, searching for new therapies, which would be able to prevent or decrease toxic kidney injury during the treatment with aminoglycosides is quite relevant. Ademetionine is an amino acid derivative, which possesses various effects such as antioxidant, membrane stabilizing, anti-inflammatory and regenerative.
Aim of the research is to study an antioxidative activity of ademetionine in conditions of gentamicin nephropathy progression in rats. Materials and methods. Research was conducted on non-linear mature white rats weighting 130-180 g, randomly divided into 3 groups (n = 7): I group included intact control animals, II group included rodents with gentamicin nephropathy (injection of 4% Gentamicin sulphate solution in a dosage of 80 mg/kg for 6 days), III group involved the rats receiving ademetionine («Abbott SpA», Italy) in a dosage of 20 mg/kg. Peroxidation processes in blood and kidneys were evaluated by the content of active products that react with thiobarbituric acid and oxidative modification of proteins levels, antioxidant defence was assessed by catalase and glutathione peroxidase activity, SH-groups and ceruloplasmin content.
Results. In the course of experimental studies on the model of gentamicin nephropathy, the expressive antioxidant activity of ademetionine was proven: it was demonstrated by reducing the intensity of lipid peroxidation (a decrease in the content of active products that react with thiobarbituric acid) and proteins (a decrease in the content of oxidative modified proteins) in the blood and kidney homogenate, next with increased activity of the enzymatic link of antioxidant protection (glutathione peroxidase and catalase) and non-enzymatic (ceruloplasmin and compounds with SH-groups). The antioxidant potential of ademetionine has been confirmed by an increase in the antioxidant-prooxidant index in kidney tissue and a significant decrease in the index of oxidative stress in the blood of treated animals.
Conclusion. Thus, the results of experimental studies indicate the antioxidative effect of ademetionine in modelled gentamicin nephropathy, and point out the necessity of further studying its potential nephroprotectective properties.
A NARRATIVE INQUIRY OF STUDENT TEACHERS MULTIMODAL PRACTICE EXPERIENCES IN THE INDONESIAN ESP CLASSROOM CONTEXT
Authors: Yanto Elih Sutisna , Pravitasari Hikmah 
Published: April 2020

Drawing on narrative inquiry aiming to understand the experience of student teachers learning context texts through different modes of meaning. This paper reports on the use of narrative frames as a mean of investigating the intersemiotic practice experiences of student teachers majoring in English education program in Karawang, West Java, Indonesia. Students in depth interview data revealed that multimodal practice has the potential to promote the role of student teachers as designers and navigators in reading English disciplinary texts. In addition, multimodal reading encourages the student teachers to become autonomous language learners. Moreover, multimodality reading tasks can scaffold students in comprehending academic language and in increasing students’ academic vocabulary development as well. These findings have implications for policy makers and teacher educators.
PENERAPAN METODE SCAFFOLDING UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA PADA PEMBELAJARAN PENJAS
Authors: Jaenudin Didin 
Published: April 2020

Pendidikan jasmani pada dasarnya merupakan bagian integral dari sistem pendidikan secara keseluruhan. Tujuan pendidikan jasmani bukan hanya mengembangkan ranah jasmani, tetapi juga mengembangkan aspek kesehatan, kebugaran jasmani, keterampilan berpikir kritis, stabilitas emosional, keterampilan sosial, penalaran dan tindakan moral melalui kegiatan aktivitas jasmani dan olah raga. Namun permasalahan muncul ketika siswa belum menyadari akan pentingnya pendidikan jasmani pada kehidupan mereka. Hal ini berdampak pada rendahnya prestasi belajar pada mata pelajaran pendidikan jasmani. Penulis mencoba menggunakan metode scaffolding sebagai solusi dari permasalahan tersebut dan dituangkan dalam sebuah penelitian. Penelitian ini merupakan penelitian tindakan kelas yang dilakukan untuk memecahkan masalah pembelajaran di kelas. Subyek penelitian adalah tempat yang digunakan dalam penelitian ini adalah siswa kelas VII-H SMP Negeri I Lemahabang Kabupaten Cirebon Tahun Pelajaran 2019/2020 sebanyak 30 siswa pada materi permainan Bola Voli. Berdasarkan hasil penelitian, metode scaffolding dalam pembelajaran permainan Bola Voli berdampak positif dalam meningkatkan prestasi belajar siswa. Peningkatan tersebut ditunjukkan dengan peningkatan ketuntasan belajar siswa dalam setiap siklus, yaitu prasiklus (36%), siklus I (60%), siklus II (96%). Dengan demikian disimpulkan, metode scaffolding dapat meningkatkan prestasi belajar siswa pada pembelajaran pendidikan jasmani.
PENERAPAN CONTEXTUAL TEACHING AND LEARNING PADA PEMBELAJARAN SENI RUPA MATERI MENGGAMBAR BENTUK
Authors: Sayadi Aung 
Published: April 2020

Dalam pelaksanaan pembelajaran seni rupa banyak siswa kelas yang belum menguasai kemampuan menggambar bentuk. Penulis melakukan upaya meningkatkan kemampuan siswa dalam menggambar bentuk dengan menggunakan Teknik Contextual Teaching and Learning. Metode yang digunakan dalam penelitian ini adalah Penelitian Tindakan kelas dengan subjek penelitian siswa kelas VII SMP Negeri 2 Palimanan sebanyak 36 siswa. Tujuan Penelitian ini adalah untuk meningkatkan kemampuan siswa kelas VII SMP Negeri 2 Palimanan dalam menggambar bentuk pada mata pelajaran Seni Rupa dengan menggunakan teknik Contextual Teaching and Learning. Penelitian dilaksanakan sebanyak dua siklus, dengan hasil Penggunaan teknik Contextual Teaching and Learning dalam pembelajaran menggambar bentuk dapat meningkatkan prestasi belajar siswa kelas VII SMP Negeri 2 Palimanan pada materi menggambar bentuk.
Comparison of standard and low-pressure pneumoperitoneum; reduction in frequency and intensity of post-operative shoulder pain
Authors: Waseem Sania , Altaf Humera Naz , Latif Sehrish , Altaf Omar Shahzad , Farooqui Fareeha , Khan Sohaib 
Published: April 2020

Laparoscopic cholecystectomy is now gold standard and depends on good exposure of the peritoneal cavity. It is achieved by insufflation of the abdominal cavity with CO2. Operating at lower intraabdominal pressure (<12 -15mmHg) has been associated with fewer pulmonary and hemodynamic complications and lesser postoperative pain.
Objective: To ascertain the advantages of low pressure pneumoperitoneum over standard pressure pneumoperitoneum
Methods: Our study was quasi experimental study conducted at KRL Hospital, Islamabad over period of 3years from 2013 to 2016. SPSS version 20 was used to calculate p value.
Results: A total of 456 patients of gallstones were equally divided in two groups assigned to undergo low pressure (7-8mm of Hg) pneumoperitoneum or standard pressure (12-14mm of Hg) pneumoperitoneum laparoscopic cholecystectomy The average age of patients was 46.2+/-13.6yrs in group A compared to 43.5 +/- 12.9 in group B. There were 60 (26.3%) male and 168 (73.7%) female patients in group A compared to 53 (23.2% and 175 (76.85) in group B respectively. It was found that group A 14 (6.1%) had no pain, 26 (11.4%) had VAS between 1 – 7 and 188 (82.5%) had VAS of 8 – 10 where as in group B 164 (72.6%) patients reported no shoulder tip pain postoperatively, 42 (18.6%) had VAS of 1 – 7 and 20 (8.8%) had VAS OF 8 – 10. The difference was statistically significant (p-value = <0.001).
Conclusions: reduced pressure of pneumoperitoneum to 7 – 8 mm of Hg produce lower incidence of postoperative shoulder tip pain.
Awareness about peripheral diabetic neuropathy among physical therapists in twin cities
Authors: Taj Saeeda , Anwar Kinza , Sajjad Abdul Ghafoor 
Published: April 2020

Objective: The main purpose of this study was to create awareness of holistic Screening approach about Peripheral Diabetic Neuropathy among Physical Therapists in Twin Cities. A descriptive cross-sectional study conducted at hospitals of Rawalpindi and Islamabad for of 6 months.
Methodology: A descriptive cross-sectional survey was carried out and non-probability purposive sampling technique was used to collect data from 110 Physical Therapists (58.1% females and 41.8% Males. A specified semi structured questionnaire was used to collect data from Physical Therapists.
Results: This study was carried out on 110 Physical Therapists. Results of our study showed that 94 (85.5%) Physical Therapists screened patients with different modalities such as 7 (6.4%) used touch perception, 6 (5.5%) used pain perception, 2 (1.8%) used vibration perception and only 1 (.9%) used ankle deep tendon reflex. 97 (88.2%) Physical Therapists assessed pain by different methods such as Pin prick method was used by 67 (60.9%) therapist, VAS was used by 15 (13.6%) therapists, 87 (79.1%) Physical Therapists assessed touch sensation. 21 (19.1%), used cotton ball, 5 (4.5%) used manual touch while 41 (37.3%) were having no specific response.
Conclusion: It is concluded that Physical Therapists of twin cities are aware of basic screening steps for Peripheral Diabetic Neuropathy and they utilize appropriate tool/modalities for assessing sensations and motor reflexes. This highlight the up to date evidence-based knowledge of PT working in twin cities.