bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management and outcomes of heart failure patients with CKD: experience from an inter‐disciplinary clinic
Authors: Nguyen Mai , Rumjaun Samir , Lowe‐Jones Racquel , Ster Irina Chis , Rosano Giuseppe , Anderson Lisa , Banerjee Debasish 
Published: July 2020

AbstractAimsCKD‐HF patients suffer excess hospitalization and mortality, often under‐treated with life‐prolonging medications due to fear of worsening renal function and hyperkalaemia. Yet, role of inter‐disciplinary working in improving therapy is unknown, which this study aims to investigate.Methods and resultsClinical, biochemical data, and medications at first and last clinic visit were obtained from patient records for 124 patients seen in kidney failure–heart failure clinic (23 March 2017 to 11 April 2019). Medication dose groups (none, low, and high dose), number of RAASi agents, and blood test results were compared between first and last visit in patients with at least two clinic visits (n = 97). Patient characteristics were age 78.5 years (IQR 68.1–84.4 years), male 67.7%, diabetes 51.6%, moderate (45.2%) vs. severe (39.5%) CKD, HF with reduced ejection fraction (HFrEF) (49.2%), follow‐up 234 days (IQR 121–441 days). HFrEF was associated with increased risk of death (adjusted OR 4.49, 95% CI 1.43–14.05; P = 0.01).Distributions of patients according to number of RAASi agents they were on differed between first and last visit (P = 0.03). Dosage was increased in 25.9% for beta‐blockers, 33.0% for ACEi/ARBs, and 17.5% for MRAs. Distributions of patients across MRA dosage groups was different (P = 0.03), with higher proportions on higher dosages at last visit, without significant changes in serum potassium or creatinine. Serum ferritin improved (131.0 vs. 267.5 μg/L; P < 0.001), and fewer patients had iron deficiency (56.7% vs. 26.8%; P = 0.002) at last visit compared to the first.ConclusionsThis inter‐disciplinary clinic improved guideline‐recommended medication prescription, MRA dosages in CKD‐HF patients without significant biochemical abnormality, and iron status. A prospectively designed study with medication titration protocol and defined patient‐centred outcomes is needed to further assess effectiveness of such clinic.
Differential effect of cardiac resynchronization therapy in patients with diabetes mellitus: a long‐term retrospective cohort study
Authors: Kahr Peter C. , Trenson Sander , Schindler Matthias , Kuster Joël , Kaufmann Philippe , Tonko Johanna , Hofer Daniel , Inderbitzin Devdas T. , Breitenstein Alexander , Saguner Ardan M. , Flammer Andreas J. , Ruschitzka Frank , Steffel Jan , Winnik Stephan 
Published: July 2020

AbstractAimsCardiac resynchronization therapy (CRT) has become an important therapy in patients with heart failure with reduced left ventricular ejection fraction (LVEF). The effect of diabetes on long‐term outcome in these patients is controversial. We assessed the effect of diabetes on long‐term outcome in CRT patients and investigated the role of diabetes in ischaemic and non‐ischaemic cardiomyopathy.Methods and resultsAll patients undergoing CRT implantation at our institution between November 2000 and January 2015 were enrolled. The study endpoints were (i) a composite of ventricular assist device (VAD) implantation, heart transplantation, or all‐cause mortality; and (ii) reverse remodelling (improvement of LVEF ≥ 10% or reduction of left ventricular end‐systolic volume ≥ 15%). Median follow‐up of the 418 patients (age 64.6 ± 11.6 years, 22.5% female, 25.1% diabetes) was 4.8 years [inter‐quartile range: 2.8;7.4]. Diabetic patients had an increased risk to reach the composite endpoint [adjusted hazard ratio (aHR) 1.48 [95% CI 1.12–2.16], P = 0.041]. Other factors associated with an increased risk to reach the composite endpoint were a lower body mass index or baseline LVEF (aHR 0.95 [0.91; 0.98] and 0.97 [0.95; 0.99], P < 0.01 each), and a higher New York Heart Association functional class or creatinine level (aHR 2.14 [1.38; 3.30] and 1.04 [1.01; 1.05], P < 0.05 each). Early response to CRT, defined as LVEF improvement ≥ 10%, was associated with a lower risk to reach the composite endpoint (aHR 0.60 [0.40; 0.89], P = 0.011). Reverse remodelling did not differ between diabetic and non‐diabetic patients with respect to LVEF improvement ≥ 10% (aHR 0.60 [0.32; 1.14], P = 0.118). However, diabetes was associated with decreased reverse remodelling with respect to a reduction of left ventricular end‐systolic volume ≥ 15% (aHR 0.45 [0.21; 0.97], P = 0.043). In patients with ischaemic cardiomyopathy, survival rates were not significantly different between diabetic and non‐diabetic patients (HR 1.28 [0.83–1.97], P = 0.101), whereas in patients with non‐ischaemic cardiomyopathy, diabetic patients had a higher risk of reaching the composite endpoint (HR 1.65 [1.06–2.58], P = 0.027). The latter effect was dependent on other risk factors (aHR 1.47 [0.83–2.61], P = 0.451). The risk of insulin‐dependent patients was not significantly higher than in patients under oral antidiabetic drugs (HR 1.55 [95% CI 0.92–2.61], P = 0.102).ConclusionsLong‐term follow‐up revealed diabetes mellitus as independent risk factor for all‐cause mortality, heart transplantation, or VAD in heart failure patients undergoing CRT. The detrimental effect of diabetes appeared to weigh heavier in patients with non‐ischaemic compared with ischaemic cardiomyopathy.
The E3 ubiquitin ligase Itch deficiency promotes antigen‐driven B‐cell responses in mice
Authors: Fang Ying , He Youdi , Zhai Bing , Hou Chunmei , Xu Ruonan , Xing Chen , Wang Xiaoqian , Ma Ning , Han Gencheng , Wang Renxi 
Published: July 2020

AbstractDeficiency of Itch, an E3 ubiquitin ligase, usually induced severe systemic and progressive autoimmune disease. The Itch function is well studied in T cells but not in B cells. We hypothesize that B‐cell‐specific Itch deficiency promoted antigen‐induced B‐cell activation and antibody‐expressing plasma cell (PC) production. We found that unlike Itch KO, Itch cKO (CD19creItchf/f) mice did not demonstrated a significant increase in the sizes of spleens and LNs, antibody level, and base mutation of antibody gene. However, in line with the fact that Itch expression decreased in GC B cells, PCs, and plasmablast (PB)‐like SP 2/0 cells, Itch deficiency promoted B‐cell activation and antibody production induced by antigens including lipopolysaccharide (LPS) and sheep red blood cells (SRBCs). Mechanistically, we found that Itch deficiency promotes antigen‐induced cytokine production because Itch controls the proteins (e.g., eIF3a, eIF3c, eIF3h) with translation initiation factor activity. Altogether, our data suggest that Itch deficiency promotes antigen‐driven B‐cell response. This may provide hints for Itch‐targeted treatment of patients with autoimmune disease.
Tissue‐resident mucosal‐associated invariant T (MAIT) cells in the human kidney represent a functionally distinct subset
Authors: Terpstra Matty L. , Remmerswaal Ester B.M. , van der Bom‐Baylon Nelly D. , Sinnige Marjan J. , Kers Jesper , van Aalderen Michiel C. , Geerlings Suzanne E. , Bemelman Frederike J. 
Published: July 2020

AbstractMucosal‐associated invariant T (MAIT) cells are innate‐like T‐cells that recognize bacterial riboflavin metabolites. They are present in human blood but are abundant at barrier sites, including the liver, lungs, and kidneys, where they possess a CD69+/CD103+/− tissue‐resident phenotype. In renal tissue, MAIT cells likely defend against the ascending uropathogens responsible for urinary tract infections (UTIs), which are common, especially among renal transplant recipients (RTRs). Nevertheless, the functional role for MAIT cells in renal tissue and the influence of renal transplantation on MAIT cells remains unclear. Using multiparameter flow cytometry and the MR1‐tetramer, we characterized MAIT cell phenotype and function in healthy renal tissue (n = 6), renal transplants explanted after allograft failure (n = 14) and in blood from healthy controls (n = 20) and RTRs before and 1‐year after transplantation (n = 21). MAIT cells in renal tissue constitute a distinct CD69+CD103+/− population that displays typical phenotypic features of tissue‐resident T‐cells and is skewed toward IL‐2, GM‐CSF, and IL‐17A production upon stimulation. The circulating MAIT cell population was not decreased in number in RTRs pre‐ or post‐transplantation. Tissue‐resident MAIT cells in the kidney represent a functionally distinct population. This shows how MAIT cells in the kidney may be involved in the protection against microorganisms.
Self‐powered light‐induced plating for III‐V/Ge triple‐junction solar cell metallization
Authors: Laucher Clément , Hamon Gwenaëlle , Turala Artur , Volatier Maïté , Darnon Maxime , Aimez Vincent , Jaouad Abdelatif 
Published: July 2020

AbstractWe present a new process to deposit thick front emitter contact on multijunction solar cells using a self‐powered light‐induced plating (SP‐LIP). This electrochemical deposition method is based on the use of the light‐induced polarization of the cell to drive the plating current instead of the use of an external power supply as for standard electroplating. The electrical characterization of the process is performed by current and potential measurements at various light intensities and enables the deposition of thick layers of various metals (Ag, Ni, and Au) on triple‐junction solar cells with a precise control of the metal thickness. The potential of SP‐LIP for the deposition of an ohmic contact layer directly on the solar cell front side without any seed layer is also demonstrated. A triple‐junction solar cell fabricated with both ohmic and thick metal front contact deposited only by an electrochemical method is reported.
Issues of theory and method in the analysis of Paleolithic mortuary behavior: A view from Shanidar Cave
Authors: Pomeroy Emma , Hunt Chris O. , Reynolds Tim , Abdulmutalb Dlshad , Asouti Eleni , Bennett Paul , Bosch Marjolein , Burke Ariane , Farr Lucy , Foley Robert , French Charles , Frumkin Amos , Goldberg Paul , Hill Evan , Kabukcu Ceren , Lahr Marta Mirazón , Lane Ross , Marean Curtis , Maureille Bruno , Mutri Giuseppina , Miller Christopher E. , Mustafa Kaify Ali , Nymark Andreas , Pettitt Paul , Sala Nohemi , Sandgathe Dennis , Stringer Chris , Tilby Emily , Barker Graeme 
Published: July 2020

AbstractMortuary behavior (activities concerning dead conspecifics) is one of many traits that were previously widely considered to have been uniquely human, but on which perspectives have changed markedly in recent years. Theoretical approaches to hominin mortuary activity and its evolution have undergone major revision, and advances in diverse archeological and paleoanthropological methods have brought new ways of identifying behaviors such as intentional burial. Despite these advances, debates concerning the nature of hominin mortuary activity, particularly among the Neanderthals, rely heavily on the rereading of old excavations as new finds are relatively rare, limiting the extent to which such debates can benefit from advances in the field. The recent discovery of in situ articulated Neanderthal remains at Shanidar Cave offers a rare opportunity to take full advantage of these methodological and theoretical developments to understand Neanderthal mortuary activity, making a review of these advances relevant and timely.
Out‐of‐sample performance of bias‐corrected estimators for diffusion processes
Authors: Guo Zi‐Yi 
Published: July 2020

AbstractWe investigated the out‐of‐sample forecasting performance of six bias‐corrected estimators that have recently emerged in the literature for the Ornstein–Uhlenbeck process: the naïve estimator, the Tang and Chen estimator, the Bao et al. estimator, the bootstrap estimator, the Wang et al. estimator, and the bootstrap estimator based on the Euler method, along with the benchmark least squares (LS) estimator. Our Monte Carlo simulations illustrated that the bias‐corrected estimators, except for the Bao et al. estimator, produced much worse out‐of‐sample forecasting performance than the LS estimator because these other estimators have a tendency to generate negative estimations of the mean reversion parameter when the true value is close to zero. However, if we set a zero lower bound to all of these estimators, including the LS estimator, all the bias‐corrected estimators improved the out‐of‐sample forecasting performance of the LS estimator as long as the true mean reversion parameter was not very large. These main results also hold for the Cox–Ingersoll–Ross process. Our real data applications confirmed these overall findings.
Moringa oleifera Lam.ameliorates the muscles function recovery following an induced insult to the Sciatic nerve in a mouse model
Authors: Razzaq Aroona , Ahmad Malik Shoaib , Saeed Farhan , Imran Ali , Rasul Azhar , Qasim Muhammad , Zafar Shamaila , Kamran Syed Kashif Shahid , Maqbool Javeria , Imran Muhammad , Hussain Ghulam , Hussain Muzzamal 
Published: July 2020

AbstractPeripheral nerve injury (PNI) is an incapacitating situation and has no effective therapy until now. We examined the possible role of crude leaves of Moringa oleifera Lam. at 200 mg/kg body weight in accelerating the functional regain in the sciatic nerve lesion induced mouse model (Adult male albino mice (BALB/c). Motor functions were evaluated by using the sciatic functional index, muscle mass, and muscle grip strength measurement, whereas the sensory functions were evaluated by using the hot plate test. Blood glucose levels and blood cell composition were also analyzed. We found that the Moringa oleifera crude leaves endorse the sensory and motor functions reclamation following the PNI with a statistically significant difference (p < .05). It also revitalizes the gastrocnemius muscle by mass restoration with glycemic management perspective. Conclusively, the crude powder of Moringa oleifera leaves exhibited a function restoration boosting property and further detailed studies for its application as a therapeutic agent are strongly recommended.
A study on the energy and exergy of Ohmic heating (OH) process of sour orange juice using an artificial neural network (ANN) and response surface methodology (RSM)
Authors: Vahedi Torshizi Mohammad , Azadbakht Mohsen , Kashaninejad Mahdi 
Published: July 2020

AbstractThe nonmodern statistical methods are often unusable for modeling complex and nonlinear calculations. Therefore, the present research modeled and investigated the energy and exergy of the ohmic heating process using an artificial neural network and response surface method (RSM). The radial basis function (RBF) and the multi‐layer perceptron (MLP) networks were used for modeling using sigmoid, linear, and hyperbolic tangent activation functions. The input consisted of voltage gradient; weight loss percentage, duration ohmic, Input flow, Power consumption, electrical conductivity and system performance coefficient and the output included the energy efficiency, exergy efficiency, exergy loss, and improvement potential. The response surface method was also used to predict the data. According to the result, the best prediction amount for energy and exergy efficiencies, exergy loss and improvement potential were in RBF network by sigmoid activation function and after this network, RSM had the best amount for energy efficiency, Also for exergy efficiencies, exergy loss and improvement potential obtained acceptable results in MLP network by a linear activation function. The worst amount was at MLP network by tangent hyperbolic. In general, the neural network can have more ability than the response surface method.
Priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects
Authors: Zhang Jinqiang , He Hui , Qiao Yan , Zhou Tao , He Haili , Yi Saini , Zhang Lijuan , Mo Li , Li Yahui , Jiang Weike , You Zili 
Published: July 2020

AbstractNeuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN‐γ was administered to mice via intracerebroventricular injection. Mice received intraperitoneal injection of ruxolitinib to inhibit the JAK/STAT1 pathway or injection of minocycline to inhibit microglial activation. During a 7‐day period, mice were assessed for depressive‐like behaviors and cognitive impairment based on a series of behavioral analyses. Effects of the activated microglia on neural stem/precursor cells (NSPCs) were examined, as was pro‐inflammatory cytokine expression by activated microglia. We showed that IFN‐γ‐injected animals showed long‐term adult hippocampal neurogenesis reduction, behavior despair, anhedonia, and cognitive impairment. Chronic activation with IFN‐γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, MHC II and CD68 up‐regulation, and pro‐inflammatory cytokine (IL‐1β, TNF‐α, IL‐6) and nitric oxide (NO) release. Microglia isolated from the hippocampus of IFN‐γ‐injected mice suppressed NSPCs proliferation and stimulated apoptosis of immature neurons. Inhibiting of the JAK/STAT1 pathway in IFN‐γ‐injected animals to block microglial activation suppressed microglia‐mediated neuroinflammation and neurogenic injury, and alleviated depressive‐like behaviors and cognitive impairment. Collectively, these findings suggested that priming of microglia with IFN‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects. Targeting microglia by modulating levels of IFN‐γ the brain may be a therapeutic strategy for neurodegenerative diseases and psychiatric disorders.
Diabetes mellitus in major head and neck cancer surgery: Systematic review and meta‐analysis
Authors: Caputo Mathew P. , Shabani Sepehr , Mhaskar Rahul , McMullen Caitlin , Padhya Tapan A. , Mifsud Matthew J. 
Published: July 2020

AbstractBackgroundDiabetes mellitus (DM) is a risk factor for surgical complications and a common comorbidity in the setting of head and neck (H&N) cancer. Our objective was to determine if DM is associated with increased rates of H&N cancer surgery complications.MethodsWe conducted a search of Pubmed, Embase, and the national clinical trials database focusing on H&N cancer surgery or free flap reconstruction and diabetes. Two reviewers screened studies by title/abstract and then full text. We then collected data using a pre‐made template. Meta‐analysis was performed using Revman 5.3.ResultsOf the 272 results from Pubmed and 559 from Embase, we selected 16 studies for inclusion. Meta‐analysis revealed DM was associated with increased rates of flap failure (risk ratio [RR] = 1.83 95% confidence interval [CI], 1.18‐2.85; P = .007) and local complications (RR = 1.87 95% CI, 1.24‐2.80; P < .00001).ConclusionAlthough DM is associated with increased risk of flap failure and local H&N cancer surgery complications, further research is required to optimize care in this population.
Nonlinear Boussinesq buoyancy driven flow and radiative heat transport of magnetohybrid nanoliquid in an annulus: A statistical framework
Authors: Thriveni K. , Mahanthesh B. 
Published: July 2020

AbstractThe effect of nonlinear Boussinesq buoyancy force on the flow of Cu‐Al2O3‐H2O hybrid nanoliquid in a vertical annulus, which is adjacent to the radial magnetic field and thermal radiation, is analyzed through a statistical approach. The phenomena of movement of annuli are taken into account. The aspect of nonlinear density temperature is also accounted based on nonlinear Boussinesq approximation (NBA). The exact solution is obtained for the two‐point boundary value problem comprised dimensionless governing equations. The skin friction coefficient and Nusselt number expressions are also estimated. The impacts of various physical parameters on the velocity, temperature, skin friction coefficient, and Nusselt number distributions are analyzed. The statistical techniques, such as correlation coefficient, probable error, and a multivariate regression model, are employed for the detailed analysis. It is found that the NBA is favorable for the skin friction coefficient and the rate of heat transfer. The maximum heat transfer is found on the wall of the internal annuli.
Multimodal medical image fusion based on the spectral total variation and local structural patch measurement
Authors: Liu Yanyu , Hou Ruichao , Zhou Dongming , Nie Rencan , Ding Zhaisheng , Guo Yanbu , Zhao Li 
Published: July 2020

AbstractMasses of research decompose the image into different levels of feature maps, but the structures and edges may not appropriately separated. This may cause the loss of image detail in the fusion process. Therefore, we design a robust method for multimodal medical image fusion using spectral total variation transform (STVT). In our method, the source images are first decomposed into a series of texture signatures (referred to as deviation components) and base components via STVT algorithm. Then combine the local structural patch measurement (LSPM) to fuse the deviation components, and the base components are merged using a spatial frequency (SF) dual‐channel spiking cortical model (SF‐DCSCM), in which the SF of base components are regarded as stimulus to activate DCSCM. Finally, the final image is reconstructed by the inverse STVT with the restored images together. Experimental results suggest that proposed scheme achieves promising results, and more competitiveness against some state‐of‐the‐art methods.
Sense of community, pathway to, or bridge from alienation?
Authors: McMillan David W. , Lorion Raymond P. 
Published: July 2020

AbstractPsychological Sense of Community (PSOC) represents a formative conceptual offering of Community Psychology to the social sciences. Nearly five decades ago, PSOC offered a window into the influence of ecological factors to understanding the emotional and behavioral well‐being of members of disenfranchised and underserved segments of the population, especially members of minority and low‐income subgroups. Our discipline's founders viewed PSOC as one promising vehicle for pursuing the desired paradigmatic shift from individual to systemically focused interventions to achieve intended outcomes of the emerging community mental health movement. This Commentary reflects the authors' shared thoughts to the adoption of PSOC by conservative spokespersons to explain the resistance of some to the diversification of the population and growing voice of progressive advocates.
Improving understanding of how mentoring works: Measuring multiple intervention processes
Authors: Tolan Patrick H. , McDaniel Heather L. , Richardson Malachi , Arkin Nora , Augenstern Julia , DuBois David L. 
Published: July 2020

AbstractThe objective is to develop and test dimensionality and validity of a new measure of five mentoring intervention processes drawn from emphases across prior mentoring efforts that might be the basis for effects: identification with the mentor, social and emotional support, teaching and education, and advocacy, and shared time and activity. Partial validation of value was drawn from moderation role in a meta‐analysis of mentoring (Tolan, Henry, Lovegrove, Schoeny, & Nichols, 2014. J. Exp. Criminol., 10, 179–201). Data collected of candidate items completed by 740 mentors and 302 mentees (mean age = 16.59 years) were subjected to confirmatory factor analyses based on the five theorized dimensions. Scales derived from best‐fitting solutions were examined for convergent validity in relation to other indicators of mentoring relationship qualities. A bifactor model with five specific factors was supported for adult mentor reports while a simplified single factor model fit youth reports. Correlations between derived scale scores and validity indicators of mentoring relationship qualities were consistent with expectations. Multiple activities that comprise mentoring can be identified in adult mentor reports but not youth reports. This scale provides a promising basis for testing how variation in emphasis during mentoring affects impact and help guide training emphases.