bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage inhibitory cytokine‐1 promotes angiogenesis by eliciting the GFRAL‐mediated endothelial cell signaling
Authors: Lee Jaeseob , Jin Young‐June , Lee Moon‐Sung , Kim Young‐Myeong , Lee Hansoo 
Published: November 2020

AbstractMacrophage inhibitory cytokine‐1 (MIC‐1) is a cytokine with pleotropic actions and its expression is markedly increased by inflammation and cardiac injury and in cancers. In particular, MIC‐1 production after cardiac ischemia injury is associated with enhanced cardiac angiogenesis as well as myocardial protection. However, it remains uncertain whether MIC‐1 itself has proangiogenic activity. In this study, we tried to determine the precise role of MIC‐1 in physiological and pathological angiogenesis. Human microvessel endothelial cells responded to MIC‐1 with enhanced angiogenic behaviors. Employing various angiogenesis assays, MIC‐1 was found to promote vessel formation and development with a potency similar to that of vascular endothelial growth factor (VEGF). MIC‐1 transgenic (Tg) mice also displayed enhanced neovascularization in both developing embryos and neonatal mouse retinas, compared with wild‐type mice. Furthermore, endothelial cells (ECs) isolated from MIC‐1 Tg mouse lung exhibited higher angiogenic potential than ECs from wild‐type lung. MIC‐1‐induced angiogenesis was also observed in the recovery or healing processes of injuries such as hindlimb ischemia and skin wounds in mice. However, unlike VEGF, MIC‐1 induced neither endothelial inflammation nor increased vascular permeability. In ECs, the MIC‐1 signal exerted proangiogenic actions via the MEK/extracellular signal‐regulated kinase‐ and phosphatidylinositol 3‐kinase/Akt‐dependent pathways. Notably, these MIC‐1 signaling events in ECs were abrogated by small interfering RNA‐mediated knockdown of GFRAL, suggesting that GFRAL is an EC receptor for MIC‐1. In summary, we here show a novel role of MIC‐1 as a potent EC activator, which promotes both normal and injury‐related angiogenesis.
Modeling the photoinactivation and transport of somatic and F‐specific coliphages at a Great Lakes beach
Authors: Safaie Ammar , Weiskerger Chelsea J. , Nguyen Tuan D. , Acrey Brad , Zepp Richard G. , Molina Marirosa , Cyterski Michael , Whelan Gene , Pachepsky Yakov A. , Phanikumar Mantha S. 
Published: November 2020

AbstractFecal indicator organisms (FIOs), such as Escherichia coli and enterococci, are often used as surrogates of contamination in the context of beach management; however, bacteriophages may be more reliable indicators than FIO due to their similarity to viral pathogens in terms of size and persistence in the environment. In the past, mechanistic modeling of environmental contamination has focused on FIOs, with virus and bacteriophage modeling efforts remaining limited. In this paper, we describe the development and application of a fate and transport model of somatic and F‐specific coliphages for the Washington Park beach in Lake Michigan, which is affected by riverine outputs from the nearby Trail Creek. A three‐dimensional model of coliphage transport and photoinactivation was tested and compared with a previously reported E. coli fate and transport model. The light‐based inactivation of the phages was modeled using organism‐specific action spectra. Results indicate that the coliphage models outperformed the E. coli model in terms of reliably predicting observed E. coli/coliphage concentrations at the beach. This is possibly due to the presence of additional E. coli sources that were not accounted for in the modeling. The coliphage models can be used to test hypotheses about potential sources and their behavior and for predictive modeling.
Synergistic effect of electromagnetic fields and nanomagnetic particles on osteogenesis through calcium channels and p‐ERK signaling
Authors: Kim Yu‐Mi , Lim Han‐Moi , Lee Eun‐Chul , Ki Ga‐Eun , Seo Young‐Kwon 
Published: November 2020

AbstractElectromagnetic fields (EMFs) are widely used in a number of cell therapies and bone disorder treatments, and nanomagnetic particles (NMPs) also promote cell activity. In this study, we investigated the synergistic effects of EMFs and NMPs on the osteogenesis of the human Saos‐2 osteoblast cell line and in a rat calvarial defect model. The Saos‐2 cells and critical‐size calvarial defects of the rats were exposed to EMF (1 mT, 45 Hz, 8 h/day) with or without Fe3O4NMPs. Biocompatibility was evaluated with MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) and LDH (lactate dehydrogenase) assays. This analysis showed that NMP and EMF did not induce cell toxicity. Quantitative reverse‐transcription polymerase chain reaction indicated that the osteogenesis‐related markers were highly expressed in the NMP‐incorporated Saos‐2 cells after exposure to EMF. Also, the expression of gene‐encoding proteins involved in calcium channels was activated and the calcium concentration of the NMP‐incorporated + EMF‐exposed group was increased compared with the control group. In particular, in the NMP‐incorporated + EMF‐exposed group, all osteogenic proteins were more abundantly expressed than in the control group. This indicated that the NMP incorporation + EMF exposure induced a signaling pathway through activation of p‐ERK and calcium channels. Also, in vivo evaluation revealed that rat calvarial defects treated with EMFs and NMPs had good regeneration results with new bone formation and increased mineral density after 6 weeks. Altogether, these results suggest that NMP treatment or EMF exposure of Saos‐2 cells can increase osteogenic activity and NMP incorporation following EMF exposure which is synergistically efficient for osteogenesis.
Predicting Need for Surgery in Recurrent Laryngotracheal Stenosis Using Changes in Spirometry
Authors: Crosby Tyler , McWhorter Andrew , McDaniel Lee , Kunduk Melda , Adkins Lacey 
Published: November 2020

Objectives/HypothesisWe sought to identify changes that occur in spirometric values between surgical interventions in patients with recurrent laryngotracheal stenosis and assess the utility of tracking those changes in predicting the need to return to surgery.MethodsThis is a retrospective, case‐control study of laryngotracheal stenosis. Charts from a 10 year period were reviewed, and 80 patients were identified with recurrent laryngotracheal stenosis and serial spirometry. Recorded forced expiratory volume in 1 second (FEV1), forced inspiratory volume in 1 second (FIV1), peak expiratory flow (PEF), and peak inspiratory flow (PIF), and body mass index (BMI) were tabulated. Calculations were then performed to determine deviations in spirometric measurements from maximums. Comparing the patients who required intervention to those who did not, we used a regression analysis to generate a decision tree based on factors with the strongest predictive power. We then calculated receiver operating characteristic (ROC) curves for all calculated variables.ResultsDeviations in PEF, PIF, and FIV1 from each patient's maximums had strong predictive power in determining return to surgery. PIF was the only fixed measurement found to have a statistically significant role in predicting return to surgery. BMI did not play a role.ConclusionFor each patient, the deviation from their overall spirometric maximums had the statistically strongest predictive power in determining need to return to surgery. This suggests the importance of the trends in spirometric measures for each individual, and implies these trends have greater import than fixed measures alone.Level of Evidence4 Laryngoscope, 131:2199–2203, 2021
Gut Mucosal Gene Expression and Metabolic Changes After Roux‐en‐Y Gastric Bypass Surgery
Authors: Jorsal Tina , Christensen Marie M. , Mortensen Brynjulf , Nygaard Eva B. , Zhang Chen , Rigbolt Kristoffer , Wandall Erik , Langholz Ebbe , Friis Steffen , Worm Dorte , Floyd Andrea , Helgstrand Frederik , Støving René K. , Aldries Alin R. , Juhl Claus B. , Østergaard Torben , Rydborg Thomas , Forman Julie L. , Sørensen Frederik , Schmidt Torsten , Falkenhahn Mechthilde , Musholt Petra B. , Theis Stefan , Larsen Philip J. , Rehfeld Jens F. , Vrang Niels , Jelsing Jacob , Vilsbøll Tina , Knop Filip K. 
Published: November 2020

ObjectiveChanges in the secretion of gut‐derived peptide hormones have been associated with the metabolic benefits of Roux‐en‐Y gastric bypass (RYGB) surgery. In this study, the effects of RYGB on anthropometrics, postprandial plasma hormone responses, and mRNA expression in small intestinal mucosa biopsy specimens before and after RYGB were evaluated.MethodsIn a cross‐sectional study, 20 individuals with obesity undergoing RYGB underwent mixed meal tests and upper enteroscopy with retrieval of small intestinal mucosa biopsy specimens 3 months before and after surgery. Concentrations of circulating gut and pancreatic hormones during mixed meal tests as well as full mRNA sequencing of biopsy specimens were evaluated.ResultsRYGB‐induced improvements of body weight and composition, insulin resistance, and circulating cholesterols were accompanied by significant changes in postprandial plasma responses of pancreatic and gut hormones. Global gene expression analysis of biopsy specimens identified 2,437 differentially expressed genes after RYGB, including changes in genes that encode prohormones and G protein–coupled receptors.ConclusionsRYGB affects the transcription of a wide range of genes, indicating that the observed beneficial metabolic effects of RYGB may rely on a changed expression of several genes in the gut. RYGB‐induced changes in the expression of genes encoding signaling peptides and G protein–coupled receptors may disclose new gut‐derived treatment targets against obesity and diabetes.
Polyaniline/Platinum Composite Cathode Catalysts Towards Durable Polymer Electrolyte Membrane Fuel Cells
Authors: Kocher K. , Hacker V. 
Published: November 2020

AbstractPolymer stabilization proved to be a promising approach to increase the catalytic performance of common platinum/carbon based cathode catalysts (Pt/C) used in polymer electrolyte membrane fuel cells (PEMFCs). Platinum and polyaniline composite catalysts (Pt/C/PANI) were prepared by combining chemical polymerization reactions with anion exchange reactions. Electrochemical ex‐situ characterizations of the decorated Pt/C/PANI catalysts show high catalytic activity toward the oxygen reduction reaction (ORR) and, more importantly, a significant enhanced durability compared to the undecorated Pt/C catalyst. Transmission electron microscopy (TEM) investigations reveal structural benefits of Pt/C/PANI for ORR catalysis. All studies confirm high potential of Pt/C/PANI for practical fuel cell application.
Rapid and Efficient Microwave‐Assisted Friedländer Quinoline Synthesis
Authors: Bailey Helen V. , Mahon Mary F. , Vicker Nigel , Potter Barry V. L. 
Published: November 2020

AbstractA microwave‐based methodology facilitates reaction of 2‐aminophenylketones with cyclic ketones to form a quinoline scaffold. Syntheses of amido‐ and amino‐linked 17β‐hydroxysteroid dehydrogenase type 3 inhibitors with a benzophenone‐linked motif were pursued using 2‐aminobenzophenone as building block. Two amido‐linked targets were achieved in modest yield, but when using microwave‐assisted reductive amination for the amino‐linked counterparts an unexpected product was observed. X‐ray crystallography revealed it as a quinoline derivative, leading to optimisation of a simple and efficient modification of Friedländer methodology. Using reagents and acetic acid catalyst in organic solvent the unassisted reaction proceeds only over several days and in very poor yield. However, by employing neat acetic acid as both solvent and acid catalyst with microwave irradiation at 160 °C quinoline synthesis is achieved in 5 minutes in excellent yield. This has advantages over the previously reported high temperatures or strong acids required, not least given the green credentials of acetic acid, and examples using diverse ketones illustrate applicability. Additionally, the unassisted reaction proceeds effectively at room temperature, albeit much more slowly.
Efficiency and selectivity of ionic liquids in microwave‐assisted extraction of major lichen phenolic compounds: a scalable process with recycling of ionic liquids
Authors: Komaty Sarah , Sauvager Aurélie , Bazureau Jean‐Pierre , Tomasi Sophie , Paquin Ludovic 
Published: November 2020

AbstractIntroductionPseudevernia furfuracea, a lichen used classically for cosmetic applications, contains interesting metabolites possessing antimicrobial and anti‐inflammatory or antioxidant properties.ObjectivesIonic liquid combined to microwave‐assisted extraction (IL–MAE) was successfully applied for metabolites extraction from Pseudevernia furfuracea.Materials and methodsThree imidazolium and pyridinium‐based ionic liquids (ILs): 1,3‐dimethylimidazolium methylsulphate [C1C1Im][MeSO4], 1‐ethyl‐3‐methylimidazolium ethylsulphate [C2C1Im][EtSO4], and N‐ethylpyridinium ethylsulphate [C2Py][EtSO4] were assessed for this process. The efficiency of the extraction method was evaluated using thin‐layer chromatography (TLC) coupled to a Camag® spectrophotodensitometer and using high‐performance liquid chromatography (HPLC) analysis.ResultsILs under MAE showed extraction time efficiency (15 min vs. 24 h for conventional heating) and high selectivity in extracting the targeted metabolites: atranorin (AT), methyl‐β‐orcinol carboxylate (MOC), fumarprotocetraric acid (Fum. Ac.), and physodic acid (Phys. Ac.) despite the increased degradation of AT under MAE. We showed a tunable selectivity of ILs towards extracting metabolites by changing anion or cation due to the modification of the interaction between the IL and the metabolites. While [C2Py][EtSO4] was the most efficient IL and could extract all the targeted metabolites, [C2C1Im][EtSO4] was the most selective. It fully extracted AT and partially Fum. Ac. Moreover, the lichen prepared by mixing procedure provided AT and Fum. Ac. more than the milled one. A 100 times scale‐up extraction was successfully performed on mixed samples with full IL recycling after back extraction.ConclusionIL–MAE is reliable for lichen metabolites extraction. The method is reproducible, scalable, with possible IL recycling, opening the door for potential industrial applications.
Parameterization and validation of a new force field for Pt(II) complexes of 2‐(4′‐amino‐2′‐hydroxyphenyl)benzothiazole
Authors: Pereira Ander Francisco , Prandi Ingrid Guarnetti , Ramalho Teodorico Castro 
Published: November 2020

AbstractUnderstanding the ways of interaction of a drug with a biological target is crucial in the pharmacology field. One methodology that allows the simulation of new drugs under in vitro conditions is the classical molecular dynamics (MD) method. However, MD simulations in systems containing metallodrugs are challenging due to the lack of specific parameters found in the literature. In this work, we propose and model a new possible anticancer platinum(II) complex: cis‐dichloro(2‐aminomethylpyridine)platinum(II) bonded to 2‐(4′‐amino‐2′‐hydroxyphenyl)benzothiazole (AHBT). The developed model consists of a new set of AMBER force field parameters based on density functional theory (DFT) calculations. The extensive validation of the parameter set shows that it adequately describes the structural properties of the complex. Overall, we expect this work to contribute significantly to future MD simulations of Pt(II) complexes in biological targets that are still not well explored, mainly due to the few parameters found in the literature.
Density functional theory computational study of [M∙Pro‐H]+ (M = Pb, Ba, or Pt) complexes in the gas phase
Authors: Shin Joong‐Won 
Published: November 2020

AbstractWe performed M06‐L and X3LYP density functional theory calculations to characterize gas‐phase structures of [Pb·Pro‐H]+, [Ba·Pro‐H]+, and [Pt·Pro‐H]+ complex isomers. Two distinct isomeric structure types, namely the A‐ and H‐type are investigated for each complex for multiplicities of 1, 3, and 5; the lowest‐energy isomers of [Pb·Pro‐H]+ and [Ba·Pro‐H]+ are singlet A‐types, whereas the lowest‐energy isomer of [Pt·Pro‐H]+ is a singlet H‐type. Vibrational bands of each isomer are assigned based on harmonic frequency analysis over the 800–4000 cm−1 range, and signature modes predicted in the spectral region below 3200 cm−1 are suggested for comparison with vibrational spectroscopy results so that isomer assignments can be made. Our study provides a more direct approach for structure elucidations of the [M·Pro‐H]+ complexes than a previous study, which reports Boltzmann population analysis based on systematic calculations to predict the most abundant isomer of the [Pb·Pro‐H]+ complex.
Limited Quadruple Modification of Various Starches in the Literature: Why?
Authors: Omodunbi Ashogbon Adeleke 
Published: November 2020

AbstractUndoubtedly, there are few publications involving quadruple modification of various starches and reasons for these are the focal point of this work. This communication looks at the problems associated with native, single modification, dual modification, and triple modification of various starches and explains the reasons for the limited work on quadruple modification of starches. These four stages process are exorbitant, each stage involves several inputs in terms of materials, energy, pressure, temperature, catalyst, reaction medium, and time.
Minds on the move: Crossing disciplines to shed new light on human cognition
Authors: Vari‐Lavoisier Ilka 
Published: November 2020

AbstractMobility is integral to mankind, but current cognitive research on migrants is almost nonexistent. Most of the existing knowledge on human cognition is based on data collected from (and by) the wealthiest and least mobile citizens of the world. In turn, most of the migration literature relies on superficial, and at times erroneous, assumptions regarding the cognitive processes underlying migratory phenomenon. However, research conducted to date in reveals striking convergences between core issues relevant to scholars in cognitive science on the one hand, and in migration studies on the other. This current lack on cross‐disciplinary dialog has no scientific grounds for two fields, which are inherently interdisciplinary, and yet it has concerning sociopolitical implications. Mapping out a novel research agenda at the crossroads of the cognitive and social sciences, this article stands as an invitation for researchers to engage in further collaborative work involving joint data collections and joint data analyses. This paper argues that researching migrant cognition would give more breadth to cognitive science and more depth to migration studies, which has the potential to better inform the design of public policies. Though the examples of (a) visual perception, (b) future‐oriented cognition, and (c) language acquisition, this article shows that pairing the discoveries of migration scholars and cognitive scientists can move forward our understanding on the human mind, in an ever‐moving world.This article is categorized under:
Economics > Individual Decision‐Making
Psychology > Theory and Methods
Psychology > Comparative Psychology
Psychology > Language
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases
Authors: Tanei Zen-ichi , Saito Yuko , Ito Shinji , Matsubara Tomoyasu , Motoda Atsuko , Yamazaki Mikihiro , Sakashita Yasuhiro , Kawakami Ito , Ikemura Masako , Tanaka Shinya , Sengoku Renpei , Arai Tomio , Murayama Shigeo 
Published: November 2020

AbstractLewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson’s disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by non-motor symptoms (NMSs) including gastrointestinal dysfunctions such as constipation. Its relationship to Lewy body-related α-synucleinopathy (Lewy pathology) of the enteric nervous system (ENS) is attracting attention because it can precede the motor symptoms. To clarify the role of ENS Lewy pathology in disease progression, we performed a clinicopathological study using the Brain Bank for Aging Research in Japan. Five-hundred and eighteen cases were enrolled in the study. Lewy pathology of the CNS and PNS, including the lower esophagus as a representative of the ENS, was examined via autopsy findings. Results showed that one-third of older people (178 cases, 34%) exhibited Lewy pathology, of which 78 cases (43.8%) exhibited the pathology in the esophagus. In the esophageal wall, Auerbach’s plexus (41.6%) was most susceptible to the pathology, followed by the adventitia (33.1%) and Meissner’s plexus (14.6%). Lewy pathology of the esophagus was significantly associated with autonomic failures such as constipation (p < 0.0001) and among PNS regions, correlated the most with LBD progression (r = 0.95, p < 0.05). These findings suggest that the propagation of esophageal Lewy pathology is a predictive factor of LBD.
Anger and aggressiveness in obsessive–compulsive disorder (OCD) and the mediating role of responsibility, non-acceptance of emotions, and social desirability
Authors: Cludius Barbara , Mannsfeld Anna K. , Schmidt Alexander F. , Jelinek Lena 
Published: November 2020

AbstractAccording to psychodynamic and cognitive models of obsessive–compulsive disorder (OCD), anger and aggression play an important role in the development and maintenance of the disorder. (Sub-) clinical samples with OCD have reported higher anger and anger suppression. Patients with checking-related symptoms of OCD showed a less aggressive self-concept as assessed by an Implicit Association Test (IAT). This study assessed anger and aggressiveness self-concepts in OCD as well as possible mediators of the link between OCD and aggressiveness. A total of 48 patients with OCD and 45 healthy controls were included. Measures included the State-Trait Anger Expression Inventory-II and an aggressiveness self-concept IAT (Agg-IAT). An inflated sense of responsibility, non-acceptance of emotions, and social desirability were tested as mediators. As expected, patients with OCD reported higher trait anger and anger suppression compared to healthy controls. Contrary to hypotheses, the aggressiveness self-concept (Agg-IAT) did not differ between groups. The inflated sense of responsibility mediated the relationship between group and anger suppression. Non-acceptance of negative emotions mediated the relationship between group and trait anger, as well as anger suppression. However, comorbidities and medication may account for some effect in anger suppression. Elevated trait anger and anger suppression in OCD patients could be explained by dysfunctional beliefs or maladaptive emotion regulation strategies. Emotion regulation therapy might help to enhance awareness and acceptance of emotions and possibly improve treatment outcomes.