bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dealing with Moral Challenges in Treatment of Transgender Children and Adolescents: Evaluating the Role of Moral Case Deliberation
Authors: Vrouenraets Lieke Josephina Jeanne Johanna , Hartman Laura A. , Hein Irma M. , de Vries Annelou L. C. , de Vries Martine C. , Molewijk Bert A. C. 
Published: June 2020

AbstractTreatment teams providing affirmative medical transgender care to young people frequently face moral challenges arising from the care they provide. An adolescent’s capacity to consent, for example, could raise several issues and challenges. To deal with these challenges more effectively, several Dutch treatment teams started using a relatively well-established form of clinical ethics support (CES) called Moral Case Deliberation (MCD). MCD is a facilitator-led, collective moral inquiry based on a real case. This study’s purpose is to describe the teams’ perceived value and effectiveness of MCD. We conducted a mixed methods evaluation study using MCD session reports, individual interviews, focus groups, and MCD evaluation questionnaires. Our results show that Dutch transgender care providers rated MCD as highly valuable in situations where participants were confronted with moral challenges. The health care providers reported that MCD increased mutual understanding and open communication among team members and strengthened their ability to make decisions and take action when managing ethically difficult circumstances. However, the health care providers also expressed criticisms of MCD: some felt that the amount of time spent discussing individual cases was excessive, that MCD should lead to more practical and concrete results, and that MCD needed better integration and follow-up in the regular work process. We recommend future research on three matters: studying how MCD contributes to the quality of care, involvement of transgender people themselves in MCD, and integration of CES into daily work processes.
Conserving orthodox seeds of globally threatened plants ex situ in the Millennium Seed Bank, Royal Botanic Gardens, Kew, UK: the status of seed collections
Authors: Liu Udayangani , Cossu Tiziana A. , Davies Rachael M. , Forest Félix , Dickie John B. , Breman Elinor 
Published: June 2020

AbstractWe reviewed the status of orthodox seed collections of globally threatened plants conserved in − 20 °C long-term storage at the Millennium Seed Bank, Royal Botanic Gardens, Kew, UK in terms of their geographic and bioclimatic representativeness, taxonomic and genetic diversity, quality and physiological status. The comprehensive dataset used spans over 45 years of worldwide conservation effort across various organisations. The data provides evidence-based results and future directions for the represented globally threatened flora that are of relevance to all plant conservation and seed banking organisations across the globe. The reviewed sample includes 523 collections and represents a wide geographic range, originating from 67 countries, from all nine bio-geographic continents. The majority of collections originated from temperate climates and from habitats with no dry seasons but experiencing warm summer periods. The taxonomic composition of the collections highlighted a substantial diversity, with 303 taxa (four extinct in the wild; 56 critically endangered; 105 endangered; and 138 vulnerable) represented by 297 species, 199 genera and 74 families. Almost four fifths of the collections were harvested from wild habitats. Whilst wild-origin collections can harbour useful genes not available in the cultivated gene pool, for threatened plants both collections and taxa are likely to suffer from low genetic diversity as a low number of individual plants, populations and/or potentially viable or usable seeds were sampled at the original harvest. Large numbers of empty and infested seeds in the original harvest have significantly affected the quality of collections in terms of availability of potentially viable or usable seeds in collections. As a result, just over one third of taxa and one fifth of collections consisted of ≥ 5000 potentially viable or usable seeds. Viable seeds exhibited a sound physiological status in terms of germinability and viability at the initial round of germination tests after storage, but on average, relative germination and viability achieved were below 85%. A decline in germinability during their variable time of storage was evident for 16% of the 78 collections analysed for longevity. According to a set of criteria, suitable germination protocols for propagation of plants from seeds were identified for 165 taxa. Given the apparent differences between wild species, especially those that are rare and threatened, and domesticated crops, the quality and physiological status of reviewed collections are reasonably sound. The characteristics we observed for collections, the challenges we identified for conserving them and the germination protocols we suggested for propagation of plants from seeds have the scope to be noted, integrated and used globally across various conservation activities and policies.
Risk prediction models versus simplified selection criteria to determine eligibility for lung cancer screening: an analysis of German federal-wide survey and incidence data
Authors: Hüsing Anika , Kaaks Rudolf 
Published: June 2020

AbstractAs randomized trials in the USA and Europe have convincingly demonstrated efficacy of lung cancer screening by computed tomography (CT), European countries are discussing the introduction of screening programs. To maintain acceptable cost-benefit and clinical benefit-to-harm ratios, screening should be offered to individuals at sufficiently elevated risk of having lung cancer. Using federal-wide survey and lung cancer incidence data (2008–2013), we examined the performance of four well-established risk models from the USA (PLCOM2012, LCRAT, Bach) and the UK (LLP2008) in the German population, comparing with standard eligibility criteria based on age limits, minimal pack years of smoking (or combination of total duration with average intensity) and maximum years since smoking cessation. The eligibility criterion recommended by the United States Preventive Services Taskforce (USPSTF) would select about 3.2 million individuals, a group equal in size to the upper fifth of ever smokers age 50–79 at highest risk, and to 11% of all adults aged 50–79. According to PLCOM2012, the model showing best concordance between numbers of lung cancer cases predicted and reported in registries, persons with 5-year risk ≥ 1.7% included about half of all lung cancer incidence in the full German population. Compared to eligibility criteria (e.g. USPSTF), risk models elected individuals in higher age groups, including ex-smokers with longer average quitting times. Further studies should address how in Germany these shifts may affect expected benefits of CT screening in terms of life-years gained versus the potential harm of age-specific increasing risk of over-diagnosis.
Radiotherapy treatment scheduling considering time window preferences
Authors: Vieira Bruno , Demirtas Derya , van de Kamer Jeroen B. , Hans Erwin W. , Rousseau Louis-Martin , Lahrichi Nadia , van Harten Wim H. 
Published: June 2020

AbstractExternal-beam radiotherapy treatments are delivered by a linear accelerator (linac) in a series of high-energy radiation sessions over multiple days. With the increase in the incidence of cancer and the use of radiotherapy (RT), the problem of automatically scheduling RT sessions while satisfying patient preferences regarding the time of their appointments becomes increasingly relevant. While most literature focuses on timeliness of treatments, several Dutch RT centers have expressed their need to include patient preferences when scheduling appointments for irradiation sessions. In this study, we propose a mixed-integer linear programming (MILP) model that solves the problem of scheduling and sequencing RT sessions considering time window preferences given by patients. The MILP model alone is able to solve the problem to optimality, scheduling all sessions within the desired window, in reasonable time for small size instances up to 66 patients and 2 linacs per week. For larger centers, we propose a heuristic method that pre-assigns patients to linacs to decompose the problem in subproblems (clusters of linacs) before using the MILP model to solve the subproblems to optimality in a sequential manner. We test our methodology using real-world data from a large Dutch RT center (8 linacs). Results show that, combining the heuristic with the MILP model, the problem can be solved in reasonable computation time with as few as 2.8% of the sessions being scheduled outside the desired time window.
Are Gettier cases disturbing?
Authors: Hawke Peter , Schoonen Tom 
Published: June 2020

AbstractWe examine a prominent naturalistic line on the method of cases (MoC), exemplified by Timothy Williamson and Edouard Machery: MoC is given a fallibilist and non-exceptionalist treatment, accommodating moderate modal skepticism. But Gettier cases are in dispute: Williamson takes them to induce substantive philosophical knowledge; Machery claims that the ambitious use of MoC should be abandoned entirely. We defend an intermediate position. We offer an internal critique of Macherian pessimism about Gettier cases. Most crucially, we argue that Gettier cases needn’t exhibit ‘disturbing characteristics’ that Machery posits to explain why philosophical cases induce dubious judgments. It follows, we show, that Machery’s central argument for the effective abandonment of MoC is undermined. Nevertheless, we engineer a restricted variant of the argument—in harmony with Williamsonian ideology–that survives our critique, potentially limiting philosophy’s scope for establishing especially ambitious modal theses, despite traditional MoC’s utility being partially preserved.
Free of salt high-pressure deliming of animal hides
Authors: Prokein Michael , Chrobot Adrian , Renner Manfred , Weidner Eckhard 
Published: June 2020

AbstractThe wastewater pollution of tanneries is of high concern. The investigation of technologies to minimize the consumption of chemicals in the leather production process can reduce the environmental burden. We focus on the reduction of ammonium salts in the leather production process. Salt-free deliming of animal hides with compressed carbon dioxide as deliming agent is performed for the first time in a technical scale 20-L drum. As a result, CO2-deliming at 30 bar and 30 °C is two times faster than conventional deliming. In addition, the deliming efficiency is slightly improved. The initial calcium (Ca) content of the hides of 8 g/kg reaches the lowest value of 2 g/kg after a process time of 3 h. However, a process time of 60 min is sufficient to reach an elimination of 50 wt% of the initial lime. The resulting Ca-content of 4 g/kg after 60 min CO2-deliming at 30 bar is comparable with the Ca-content of conventional delimed hide. We clarify that the ampholytic character of the collagen itself enables a buffering of the pH-value at pH-7. The stable pH-value supports the selection of specific bating enzymes that decompose non-collagen proteins. No buffering salts contaminate the wastewater. The high-pressure CO2-deliming process has high potential to reduce wastewater emissions, save costs for chemicals, and process time in industrial beamhouse applications.
(Neuro)therapeutic Approaches in the Field of Alcohol Use Disorders
Authors: Beck A , Rosenthal A , Auriacombe M , Romanczuk-Seiferth N 
Published: June 2020

AbstractPurpose of ReviewAlcohol use disorder (AUD) is a burdening chronic condition that is characterized by high relapse rates despite severe negative consequences. There has been a recent emergence of interest in (neuro)therapeutic intervention strategies that largely involve the detrimental change in mechanisms linked to addiction disorders. Most prominently, the latter include habitual decision-making, cue-induced behavioral tendencies, as well as the amplifying effects of stressful events on drinking behavior. This article discusses these learning mechanisms and modification thereof as possible targets of (neuro)therapeutic interventions for AUD.Recent FindingsPsychological therapies that target dysregulated neurocognitive processes underlying addictive behavior may hold promise as effective treatments for AUD.SummaryDespite the progression in psychological and neuroscience research in the field of AUD, many behavioral interventions fail to systematically integrate and apply such findings into treatment development. Future research should focus on the targeted modification of the aforementioned processes.
A Review of the Potential Impacts of Wind Turbine Noise in the Australian Context
Authors: Davy John Laurence , Burgemeister Kym , Hillman David , Carlile Simon 
Published: June 2020

AbstractThis manuscript describes a range of technical deliberations undertaken by the authors during their work as members of the Australian Government’s Independent Scientific Committee on Wind Turbines. Central to these deliberations was the requirement upon the committee to improve understanding and monitoring of the potential impacts of sound from wind turbines (including low frequency and infrasound) on health and the environment. The paper examines existing wind turbine sound limits, possible perceptual and physiological effects of wind turbine noise, aspects of the effects of wind turbine sound on sleep health and quality of life, low-frequency noise limits, the concept of annoyance including alternative causes of it and the potential for it to be affected by low-frequency noise, the influence of amplitude modulation and tonality, sound measurement and analysis and management strategies. In so doing it provides an objective basis for harmonisation across Australia of provisions for siting and monitoring of wind turbines, which currently vary from state to state, contributing to contention and potential inequities between Australians, depending on their place of residence.
Protecting Citizens’ Personal Data and Privacy: Joint Effort from GDPR EU Cluster Research Projects
Authors: de Carvalho Renata M. , Del Prete Camillo , Martin Yod Samuel , Araujo Rivero Rosa M. , Önen Melek , Schiavo Francesco Paolo , Rumín Ángel Cuevas , Mouratidis Haralambos , Yelmo Juan C. , Koukovini Maria N. 
Published: June 2020

AbstractConfidence in information and communication technology services and systems is crucial for the digital society which we live in, but this confidence is not possible without privacy-enhancing tools and technologies, nor without risks management frameworks that guarantee privacy, data protection, and secure digital identities. This paper provides information on ongoing and recent developments in this area in the European Union (EU) space. We start by providing an overview of EU’s General Data Protection Regulation (GDPR) and proceed by identifying challenges concerning GDPR implementation, either technical or organizational. For this, we consider the work currently being done by a set of EU projects on the H2020 DS-08-2017 topic, namely BPR4GDPR, DEFeND, SMOOTH, PDP4E, PAPAYA and PoSeID-on, which address and aim at providing specific, operational solutions for the identified challenges. We briefly present these solutions and discuss the ways in which the projects cooperate and complement each other. Finally, we identify guidelines for further research.
Detection, Classification, and Location of Seismovolcanic Signals with Multicomponent Seismic Data: Example from the Piton de La Fournaise Volcano (La Réunion, France)
Authors: Journeau C. , Shapiro N. M. , Seydoux L. , Soubestre J. , Ferrazzini V. , Peltier A. 
Published: June 2020

AbstractWe apply three different methods based on the analysis of the multicomponent seismic data to detect seismovolcanic tremors and other seismovolcanic signals, to propose an approach to classify them, and to locate their sources. We use continuous seismograms recorded during 1 year by 21 stations at the Piton de la Fournaise volcano (La Réunion, France). The first method allows the detection of seismovolcanic signals based on stability in time of the intercomponent cross‐correlation function. Two other methods based on the simultaneous analysis of the whole network can be used to detect seismovolcanic signals and to locate their sources. In the first network‐based method, the seismic wavefield is analyzed by calculating the width of the network covariance matrix eigenvalue distribution.The second network‐based method consists in performing the 3‐D backprojection of the interstation cross correlations in order to calculate the network response function. Simultaneous analysis of the parameters measured by the three different methods can be used to classify different types of seismovolcanic tremors. Our results demonstrate that all three methods efficiently detect seismovolcanic tremors accompanying the 2010 eruptions and the preceding pre‐eruptive seismic swarms. Furthermore, Methods 2 and 3 based on simultaneous analysis of the whole network detect a large number of volcanic earthquakes. Our location results show that each seismovolcanic tremor is located in a distinct regionof the volcano, close to the eruptive site at a shallow depth, and the preceding seismic crisis is located deeper at about the sea level under the summit crater.
The Range of Jupiter's Flow Structures That Fit the Juno Asymmetric Gravity Measurements
Authors: Duer Keren , Galanti Eli , Kaspi Yohai 
Published: June 2020

AbstractThe asymmetric gravity field measured by the Juno spacecraft has allowed the estimation of the depth of Jupiter's zonal jets, showing that the winds extend approximately 3,000 km beneath the cloud level. This estimate was based on an analysis using a combination of all measured odd gravity harmonics, J3, J5, J7, and J9, but the wind profile's dependence on each of them separately has yet to be investigated. Furthermore, these calculations assumed the meridional profile of the cloud‐level wind extends to depth. However, it is possible that the interior jet profile varies somewhat from that of the cloud level. Here we analyze in detail the possible meridional and vertical structure of Jupiter's deep jet streams that can match the gravity measurements. We find that each odd gravity harmonic constrains the flow at a different depth, with J3 the most dominant at depths below 3,000 km, J5 the most restrictive overall, whereas J9 does not add any constraint on the flow if the other odd harmonics are considered. Interior flow profiles constructed from perturbations to the cloud‐level winds allow a more extensive range of vertical wind profiles, yet when the meridional profiles differ substantially from the cloud level, the ability to match the gravity data significantly diminishes. Overall, we find that while interior wind profiles that do not resemble the cloud level are possible, they are statistically unlikely. Finally, inspired by the Juno microwave radiometer measurements, assuming the brightness temperature is dominated by the ammonia abundance, we find that depth‐dependent flow profiles are still compatible with the gravity measurements.
Estimating Arctic Temperature Impacts From Select European Residential Heating Appliances and Mitigation Strategies
Authors: Seay Brannon , Adetona Anna , Sarofim Marcus , Kolian Michael 
Published: June 2020

AbstractThe use of residential heating devices is a key source of black carbon and other short‐lived climate forcer emissions in Arctic and other high‐latitude regions, with important impacts to the Arctic climate and human health. The types of combustion technologies and fuels used vary by region, which impacts the emission profiles of these pollutants and thus the magnitude of Arctic climate responses. Using emission inventory data from 14 European countries, we derive wood‐fueled residential heating emissions of black carbon, organic carbon, and sulfate from six appliance types in 2016. Using previously derived equilibrium Arctic temperature responses, we estimate Arctic temperature influences from each appliance type. Using the 2016 appliance emission data as a baseline, we compute the emission mass and Arctic temperature mitigation potential from hypothetical stove conversion scenarios. A total of 43.2 gigagrams (Gg) of black carbon, 175.7 Gg of organic carbon, and 10.3 Gg of sulfate were emitted in 2016 from the six appliance types in the 14 countries. The combined emissions increased Arctic surface temperatures by +2.8 millikelvin. If each country converted its appliance fleet to the technologically advanced pellet stoves and boilers, the combined black carbon, organic carbon, and sulfate emissions from heating appliances could be reduced by 94% and the Arctic temperature response reduced by 85%. The specific source and originating region of emissions are important factors in resolving the magnitude of their impacts. Improved country‐level accounting of specific appliances and their emission characteristics can lead to a better understanding of potential mitigation options.
A Statistical Study on the Winter Ionospheric Nighttime Enhancement at Middle Latitudes in the Northern Hemisphere
Authors: Li Wenbo , Chen Yiding , Liu Libo , Le Huijun , Zhang Ruilong , Li Jiacheng , Huang Cong 
Published: June 2020

AbstractThe ionospheric electron density generally decreases after sunset under the effect of recombination, but sometimes, it increases, which forms an ionospheric nighttime enhancement (INE). In this research, the observations from two ionosondes in Mohe and Beijing and NASA's Jet Propulsion Laboratory‐Global Ionosphere Maps during the 24th solar cycle were used to explore the feature and mechanism of INE at midlatitudes. It shows that hmF2 always increases when INE occurs in summer, while it either rises or falls in winter. The increase of hmF2 has a significant contribution to INE in summer. For winter INE, however, the hmF2‐rising and the hmF2‐declining type INEs present no significant differences in durations and amplitudes, except that the former occurs slightly earlier than the latter. This suggests that the uplift of the ionosphere induced by equatorward thermospheric wind may not be a dominant factor for controlling the formation of winter INE at midlatitudes. We found that the electron density difference between the summer hemisphere and the winter hemisphere trends increases when the INE occurs in the winter hemisphere. This increased electron density difference between the two hemispheres is beneficial to the summer‐to‐winter interhemispheric plasma transport and the formation of INE in winter. Meanwhile, it is likely that the ionospheric equivalent slab thickness decreases during the winter INE due to downward transport from the topside. These indicate that downward plasma influxes from the topside ionosphere and the conjugate summer hemisphere play dominant roles for the formation of winter INE at middle latitudes.