bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Dependent Compressibility of Crude Oil in Gelled State Measured by a New Apparatus
Authors: Chen Lei , Ding Jinghua , Gao Junjie , Ren Shuyi , Gao Jingyang , Liu Gang 
Published: June 2020

Summary
Compressibility is a basic property of gelled crude oil, which was always regarded as a constant in the unsteady-pipe-flow process. In this article, the compressibility of gelled crude oil was accurately measured, and some new characteristics were discovered by a new apparatus that was developed using a special sealing method consisting of an elastic film and the Newtonian fluid. There was no leakage in the special hermetical method, and the unexpected seal-ring deformation of the piston in the traditional compression apparatus was also well-avoided. Using the new apparatus, compressibility of the gelled crude oil was tested and it was found that the compressibility of gelled crude oil is strongly time dependent.
A Classification-Based Surrogate-Assisted Multiobjective Evolutionary Algorithm for Production Optimization under Geological Uncertainty
Authors: Zhao Mengjie , Zhang Kai , Chen Guodong , Zhao Xinggang , Yao Jun , Yao Chuanjin , Zhang Liming , Yang Yongfei 
Published: June 2020

Summary
Multiobjective optimization (MOO) is a popular procedure for waterflooding optimization under geological uncertainty that maximizes the expectation of net present value (NPV) over all possible uncertainty models and minimizes the variance simultaneously. However, the optimization process involves a large number of decision variables, and the problem is computationally expensive. Surrogate-assisted evolutionary algorithms (SAEAs), which have proved to be an effective way to solve expensive problems, design computationally inexpensive functions to approximate each objective function. On the basis of characterization, we have designed an efficient multiobjective evolutionary algorithm (MOEA) to effectively deal with computationally expensive simulation-based optimization problems. The uniqueness of this algorithm is that it incorporates a Pareto-rank-learning scheme with surrogate-assisted infill criterion. The first is to introduce a multiclass error-correcting output codes (ECOC) model that directly predicts the dominance relationship between candidate solutions and prescreens, and the second is to train a radial-basis function (RBF) network that predicts the objective functions of prescreened solutions to calculate the hypervolume (HV) improvement that maintains convergence and diversity. Compared with typical surrogate-based methods, the developed method provides a classifier first that can enhance the accuracy in high dimensions and reduce computational complexity. To the best of our knowledge, the proposed method compares with state-of-the-art surrogate frameworks for multiobjective production-optimization problems. In this paper, the proposed approach is applied to two 200D benchmark problems and two synthetic reservoir models. The results show that the proposed method can achieve more comprehensive and efficient reservoir management (RM) with a higher convergence speed compared with traditional MOEAs and surrogate-assisted optimization methods.
Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis
Authors: Lin Juli , Lin Jian-xian , Zheng Chao-hui , Li Ping , Xie Jian-wei , Wang Jia-bin , Lu Jun , Chen Qi-yue , Cao Long-Long , Lin Mi , Huang Chang-ming 
Published: June 2020

Abstract
Background: Many studies have found that use of aspirin can lengthen survival in patients with gastrointestinal cancer. The aim of this study was to assess the survival benefit of aspirin use compared with non-aspirin use for patients with esophageal, gastric or colorectal cancer. Methods: We searched online databases, including PubMed, the Cochrane Library, Embase and www.clinicaltrials.gov for studies that were conducted,, before April 30th, 2020, to identify relevant studies. Overall survival and cancer-specific survival of esophageal, gastric and colorectal cancers among aspirin users were compared with those among non-aspirin users. Data extraction and quality evaluation were independently conducted by 2 investigators. A meta-analysis was performed to calculate the pooled risk ratios (RRs) for overall survival and cancer-specific survival by using either a fixed-effects model or a random-effects model. Results: A total of 18 studies were included in this meta-analysis, with more than 74,936 patients. There were no significant differences between postdiagnosis aspirin use and overall survival for esophageal and gastric cancers. For colorectal cancer, a benefit that was associated with postdiagnosis aspirin use was observed for overall survival and cancer-specific survival [HR= 0.83, 95%CI(0.75, 0.9.);HR= 0.78, 95%CI(0.66, 0.92), respectively. However, a prediagnosis of aspirin use did not provide a benefit for overall or cancer-specific survival in colorectal cancer. HR values for overall and cancer-specific survival benefits for colorectal cancer associated with both prediagnosis and postdiagnosis aspirin were as follows: HR=0.75，95%CI(0.61, 0.92) and HR=0.78, 95%CI(0.73, 0.85), respectively. In addition, the survival benefit of postdiagnosis aspirin use appeared to be confined to patients with mutated PIK3CA tumors [HR= 0.78, 95%CI(0.50, 0.99)] and was positive for PTGS2 (COX-2) expression [HR= 0.75, 95%CI(0.43, 1.30)]. Conclusions: These findings provide further indications that postdiagnosis aspirin use improves overall survival and cancer-specific survival in colorectal cancer, especially for patients who are positive for PTGS2 (COX-2) expression and PIK3CA-mutated tumors. However, aspirin therapy does not improve overall survival in esophageal and gastric cancers, although the meta-analysis was mainly limited to retrospective studies.
Substance P Induces Sympathetic Immune Response in the Contralateral Eye after the First Eye Cataract Surgery in Type 2 Diabetic Patients
Authors: Gong Xianhui , Ren Yueping , Pan Wenjie , Zheng Jingwei , Fang Xiuxiu , Cai Junyong , Song E 
Published: June 2020

Abstract
Background: Substance P (SP) is a nociceptive tachykinin which regulates the immune inflammatory reactions including monocyte chemoattractant protein 1 (MCP-1) production. Sequential second-eye cataract surgery patients often suffer more pain than the first one partly because of the MCP-1 increase in aqueous humor (AH). This study aims to illustrate whether SP is involved in sympathetic inflammatory responses in the contralateral eye in patients with or without type 2 diabetes.Methods: This prospective randomized clinical study included 51 cataract patients (22 with diabetes and 29 without). Bilateral sequential cataract surgeries were conducted with 1-day or 1-week interval randomly. More than 100 µl of AH were obtained before surgery and stored for later analysis using magnetic Luminex assays to detect interleukin (IL)-1β, IL-1ra,IL-6, IL-8, IL-10, MCP-1, vascular endothelial growth factor, spinal macrophage inflammatory protein (MIP-1a), interferon-inducible protein 10 (IP-10), regulated on activation, normal T expressed and secreted (RANTES), as well as the enzyme-linked immunosorbent assay for SP.Results: Among the 4 groups, no significant differences were found in age, sex distribution, the R/L ration of the first surgery eye, or the lens nucleus hardness (P ≥ 0.802). Over 100 µl of AH samples were collected safely in all cases without intraoperative complications. SP and MCP-1 levels were both increased significantly in the second eye of the diabetic patients with 1-day and 1-week interval (P ≤ 0.040). The SP increase in the second eye of the diabetic patients were significantly higher than that of the patients without diabetes (P ≤ 0.030) both in the groups with 1-day and 1-week interval. Similarly, the MCP-1 increase was significantly higher in the diabetic patients in the group with 1-week interval (P = 0.042). Conclusions: Substance P and MCP-1 productions elevated in the AH of the contralateral eye after the first-eye cataract surgery in diabetic patients, indicating that SP and MCP-1 were involved in the sympathetic inflammatory responses. Diabetic patients are susceptible to noninfectious inflammation after cataract surgery, and perceive more pain in the second-eye phacoemulsification. Trial registration: Chinese Clinical Trial Registry, ChiCTR1900028374, retrospectively registered on 20th December, 2019.
A participatory approach to marsh deer (Blastocerus dichotomus) morbidity and mortality passive surveillance in Argentina: first results.
Authors: Orozco Maria Marcela , Argibay Hernán D. , Minatel Leonardo , Guillemi Eliana C. , Berra Yanina , Schapira Andrea , Nucci Dante Di , Marcos Andrea , Lois Fernanda , Falzone Martin , Farber Marisa D. 
Published: June 2020

Abstract
Background: The comprehensive approach to diseases in broad ecological contexts appears as a new challenge for global health. Winter mortality of marsh deer ( Blastocerus dichotomus ) was historically described in Argentina even though field difficulties prevented their in-depth study. Results: Between May 2014 and April 2017, we investigated marsh deer morbidity and mortality through passive surveillance in the two largest populations in Argentina using a participatory approach. The latter spanned a network of researchers, field partners (veterinarians, park rangers, and local community), and decision makers. We sampled dead deer during as well as outside mortality events. A total of 44 marsh deer with different body condition scores were evaluated. We obtained reference haematology and biochemistry values from animals with good body condition score. Marsh deer with poor body condition had a high burden of the ticks Amblyomma triste and Rhipicephalus microplus . Vector-borne agents (VBAs), such as Theileria cervi , Trypanosoma theileri, Trypanosoma evansi, Ehrlichia chaffeensis, Anaplasma platys, Anaplasma odocoilei, Anaplasma marginale , and Candidatus Anaplasma boolense were also found. Haemonchus spp., Ostertagia spp., and Trichostrongylus spp. were the most frequent gastrointestinal parasites in deer with poor body condition. A Multiple Correspondence Analysis reinforced a possible association of winter period with lower body score condition, high tick loads, infection with E. chaffeensis , and presence of harmful gastrointestinal parasites. Conclusions: Our approach allowed the establishment of a participatory surveillance network of marsh deer morbidity and mortality in Argentina. We report and analyse the first data obtained opportunistically within the framework of this network, providing information on the infectious and parasitic agents in marsh deer populations. The occurrence of Fasciola hepatica and Leptospira interrogans serovar pyrogenes is reported for the first time in wild marsh deer from Argentina. The histopathological findings in succumbed animals allowed us to distinguish lesions associated with their body condition from those that were unrelated. Our data will be useful to improve the interpretation of future mortality events. The field implementation of a surveillance network is key to a holistic approach to wildlife diseases.
The role of mass media exposure on Tuberculosis knowledge and attitude among migrant and seasonal farmworkers in Northwest Ethiopia
Authors: Gelaye Kassahun Alemu , Debalkie Getu , Ayele Tadesse Awoke , Wami Sintayehu Daba , sisay Malede mequanent , Fetene Destaw , Wolde Haileab Fekadu , Akalu Temesgen Yihunie 
Published: June 2020

Abstract
Background: Globally, tuberculosis (TB) is the 10th leading cause of death. Despite no country achieved its target, the world health organization (WHO) proposed a 90-90-90 approach to fastening the end TB strategy. Improvement and progression of TB control need good knowledge and a favorable attitude towards the disease. However, interventions designed don’t take migrants and seasonal farmworkers into account. Therefore, this study aimed at estimating the level of knowledge and attitude on Tuberculosis among migrant and seasonal farmworkers in northwest Ethiopia. Methods: Community-based cross-sectional study was conducted in the West Gondar zone from October to November 2018. A two-stage cluster sampling was used to select 949 migrant and seasonal farmworkers. Both bivariate and multivariable logistic regression analyses were performed. A p-value of <0.05 was used to declare statistical significance. The goodness of fit was checked using Hosmer and Lemeshow test. Results: In this study, (41.8%), (95% CI: 38.73, 45.01) and (50.5%), (95% CI: 47.29, 53.65) of migrants and seasonal farmworkers had good knowledge and a favorable attitude, respectively. The odds of good knowledge among mass media exposed migrants were AOR=1.42, 95% CI: (1.02, 2.01). Moreover, urban residence and having good knowledge increase the odds of favorable attitude by 1.66, (AOR=1.7; 95% CI: 1.05, 2.62) and 4.3 (AOR=4.3, 95%CI: 3.26, 5.75), respectively. Conclusion: In this study, the overall knowledge and attitude of migrant and seasonal farmworkers on TB were low. Family size and mass media exposure significantly affect knowledge of the migrants on TB. On the other hand, the attitude was affected by urban residence, health information, and having good knowledge. Health promotion interventions, focused on TB cause, mode of transmission, prevention, and treatment are important to migrant and seasonal farmworkers to improve the knowledge and attitude of migrants and seasonal farmworkers.
Barriers to patient, provider, and caregiver adoption and use of electronic personal health records in chronic care: a systematic review
Authors: Niazkhani Zahra , Toni Esmaeel , Cheshmekaboodi Mojgan , Georgiou Andrew , Pirnejad Habibollah 
Published: June 2020

Abstract
Background: Electronic personal health records (ePHRs) are defined as electronic applications through which individuals can access, manage, and share health information in a private, secure, and confidential environment. Existing evidence shows their benefits in improving outcomes, especially for chronic disease patients. However, their use has not been as widespread as expected partly due to barriers faced in their adoption and use. We aimed to identify the types of barriers to a patient, provider, and caregiver adoption/use of ePHRs and to analyze their extent in chronic disease care.Methods: A systematic search in Medline, PubMed, Science Direct, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Central Register of Controlled Trials, and the Institute of Electrical and Electronics Engineers (IEEE) database was performed to find original studies assessing barriers to ePHR adoption/use in chronic care until the end of 2018. Two researchers independently screened and extracted data. We used the PHR adoption model and the Unified Theory of Acceptance and Use of Technology to analyze the results. The Mixed Methods Appraisal Tool (MMAT) version 2018 was used to assess the quality of evidence in the included studies.Results: Sixty publications met our inclusion criteria. Issues found hindering ePHR adoption/use in chronic disease care were associated with demographic factors (e.g., patient age and gender) along with key variables related to health status, computer literacy, preferences for direct communication, and patient’s strategy for coping with a chronic condition; as well as factors related to medical practice/environment (e.g., providers’ lack of interest or resistance to adopting ePHRs due to workload, lack of reimbursement, and lack of user training); technological (e.g., concerns over privacy and security, interoperability with electronic health record systems, and lack of customized features for chronic conditions); and chronic disease characteristics (e.g., multiplicities of co-morbid conditions, settings, and providers involved in chronic care).Conclusions: ePHRs can be meaningfully used in chronic disease care if they are implemented as a component of comprehensive care models specifically developed for this care. Our results provide insight into hurdles and barriers mitigating ePHR adoption/use in chronic disease care. A deeper understating of the interplay between these barriers will provide opportunities that can lead to an enhanced ePHR adoption/use.
dTBI: A paradigm for closed-head injury in Drosophila
Authors: Saikumar Janani , Kim Joshua , Byrns China N. , Hemphill Matthew , Meaney David F. , Bonini Nancy M. 
Published: June 2020

Abstract
Drosophila models have been instrumental in providing insights into molecular mechanisms of neurodegeneration, that are applicable to human disease. We have recently described a model of controlled head injury to flies, which remarkably parallels many of the physiological responses of humans to traumatic brain injury (TBI). This protocol describes the construction, calibration and use the of the Drosophila TBI (dTBI) device, a platform that employs a piezoelectric actuator to reproducibly deliver a force, which briefly compresses the fly head against a metal surface. The extent of head compression can be specified, allowing the operator to set different thresholds of injury. Using readily available components and tools, the device can be assembled and calibrated within two days, for a total cost of ~$700. The dTBI device can be used to harness the power of Drosophila genetics and perform large-scale genetic or pharmacological screens, using a 7-day post-injury survival curve to identify modifiers of injury.
COVID-19 mortality and BCG vaccination: defining the link using machine learning
Authors: Brooks Nathan A. , Puri Ankur , Garg Sanya , Nag Swapnika , Corbo Jacomo , Turabi Anas El , Kaka Noshir , Zemmel Rodney W. , Hegarty Paul K. , Kamat Ashish M. 
Published: June 2020

Abstract
Population-level data have suggested that bacille Calmette-Guerin (BCG) vaccination may lessen the severity of COVID-19; prior reports have demonstrated conflicting results. We leveraged publicly available databases and unsupervised machine learning, adjusting for established confounders designated a priori, to assign countries into similar clusters. The primary outcome was the association of deaths per million related to COVID-19 (CSM) 30 days after each included country reported 100 cases with several factors including vaccination. Validation was performed using linear regression and country-specific modeling. This protocol details the statistical analyses used to establish an association between BCG vaccination and CSM, which includes : Definition of the target function, data processing, exploratory factor analysis for variable selection, k-means clustering and step wise linear regression for validation. This protocol is differentiated from previous works on the same subject by its' comprehensive nature which considers the effect of several confounding variables while studying the association between BCG vaccination and CSM. There are still several potential measured and unmeasured confounding variables which could not be included in this study. It is also unclear if the protection from neonatal vaccination with BCG is transferable to those receiving vaccination as an adult and how long such protection lasts. The authors advise caution against routine BCG vaccination for the prevention of COVID-19 until prospective trials are completed.
Effects of virtual reality associated with serious games for upper limb rehabilitation in patients with multiple sclerosis. A randomized controlled trial
Authors: Cuesta-Gómez Alicia , Baeza Patricia Sanchez-Herrera , Oña-Simbaña Edwin Daniel , Martínez-Medina Alicia , Ortiz-Comino Carmen , de Quirós Carlos Balaguer-Bernaldo , Jardón-Huete Alberto , Cuerda Roberto Cano-de la 
Published: June 2020

Abstract
Background: Dexterity and activities of daily living limitations on the upper limb (UL) represent one of the most common problems in patients with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of the specially developed Serious Games that make use of the Leap Motion Controller (LMC) as main user interface for improving UL grip muscle strength, dexterity, fatigue, quality of life, satisfaction and compliance.Methods: A single-blinded randomized controlled trial was conducted. The sample was randomized into two groups: an experimental group who received treatment based on serious games designed by the research team using the developed LMC based Serious Games for the UL plus conventional rehabilitation, and a control group who received the same conventional rehabilitation for the UL. Both groups received two 60 min sessions per week over a ten-week period. Grip muscle strength, coordination, speed of movements, fine and gross UL dexterity, fatigue, quality of life, satisfaction and compliance were assessed in both groups pre-treatment, post-treatment and in a follow-up period of one month without receiving any treatment.Results: In the experimental group compared to the control group, significant improvements were observed in the post-treatment assessment for coordination, speed of movements, fine and gross UL dexterity. Also, significant results were found in the follow-up in coordination, speed of movements, fine and gross for the more affected side. Conclusions: An experimental protocol using an LMC based Serious Games designed for UL rehabilitation showed improvements for unilateral gross manual dexterity, fine manual dexterity, and coordination in MS patients with high satisfaction and excellent compliance. Trial registration: This randomized controlled trial has been registered at ClinicalTrials.gov Identifier: NCT04171908, Nov 2019.
The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults
Authors: Xu Ren-ying , Jiang Xiaomin , Fan Zhuping , Wan Yanping , Gao Xiang 
Published: June 2020

Abstract
Background: We performed a cohort study to evaluate the association between the CRP trajectory and incident diabetes in Chinese adults. Methods: Included were 6,439 adults (4,111 men and 2,249 women; aged 46.6±11.9 years). The concentration of high sensitivity CRP (hs-CRP) was measured in 2013 (baseline), 2014, and 2015. The hs-CRP trajectory was identified based the above three measurements by latent mixture modeling. Incident diabetes cases were diagnosed by fasting blood glucose (³126mg/dl) or Hb A1c (³6.5%) during subsequent three years (2016-2018). Results: Hs-CRP concentration during 2013 -2015 was classified into 3 levels: low (<1.0 mg/L), moderate (1.0–3.0 mg/L), and high (³3.0 mg/L) based on a statement by American Heart Association. We named four hs-CRP trajectories as following: “low-stable” (low in 2013 and maintained at low concentration in 2014 and 2015), “moderate-fluctuated” (moderate in 2013, then increased to high concentration in 2014, and decreased to low concentration in 2015), “high-decreased” (high in 2013 but decreased to moderate concentration in 2014 and 2015), and “moderate-increased (moderate in 2013 and increased to high concentration in 2014 and 2015)”. We identified 235 incident diabetes during subsequent three years. The adjusted HR for incident diabetes was 1.71 (95% CI: 1.02, 2.87) comparing the moderate-increased and the low-stable group, after adjusting for potential confounders. In the secondary analyses, two single-measured hs-CRP concentration (in 2013 or in 2015) and the average of hs-CRP were associated with high risk of diabetes (P-trend<0.01 for all). Conclusions: The hs-CRP trajectory pattern was associated with altered incident diabetes in Chinese adults.