bluuebunny/crossref_metadata_2025_split huggingface dataset:
The persistent challenges and strategies for effective rehabilitation among obstetric fistula patients at Kitovu Mission Hospital, Uganda: a qualitative study
Authors: Atuhaire Shallon , Odukogbe Akin Tunde A. , Mugisha John F. , Ojengbede Oladosu A. 
Published: March 2020

Background: Obstetric fistula poses a great physical, psychosocial and economic burden to girls and women in low and middle-income countries. About 53% of the obstetric fistula patients may live with untreated fistula for more than a year, thus patients require rehabilitation as they await repair and after repair. Little qualitative research exists on rehabilitation particularly on the challenges and effective strategies that inspired this study.Methods: A cross-sectional qualitative research approach used in-depth interviews and key informant interviews to collect data from 10 obstetric fistula patients who had been registered by the Urogynecology Department, Kitovu Hospital within two years before the time of data collection status and 12 key informants who include hospital staffs engaged in the management of fistula and patients’ partners who were involved in caregiving. Data were analyzed thematically using ATLAS.ti 7.5.Results: The major constraints encountered during rehabilitation were limited resources for practice, inadequate counseling especially among immediate relatives, and inadequate capital for self-sustainability and limited employment opportunities. Key informants also mentioned the issue of limited resources, budget constraints, inadequate supervision and follow up of patients. Only one patient who had not had fistula repair had knowledge of rehabilitation. To address the challenges, the participants suggested the need for rehabilitation despite repair status. They required more knowledge about sustainable livelihood programs and cash grants.Conclusions: The patients identified socioeconomic, institutional and political challenges to their rehabilitation. They emphasized the need for improved political commitment, adequate budget, and resource allocation and regular support supervision to ensure their effective rehabilitation.
Sustainability of Fish Fillet Processing Industries in Batang District
Authors: Dewinta Astrid Fauzia , Farid Ma’ruf Widodo 
Published: March 2020

HighlightsSustainability index from fish fillet industry is important to know because a fishing industry just not looking for feasibility study in economic dimension but all dimension (resources, technology, social, legal and institutional)Multidimension sustainability index from fish fillet processing industry in Batang is included in the category of “Self Sustainable” with a value of 50.39 The dimensions causes of the low sustainability in fish fillet industry are social, legal and institutional, and technology with the value of each dimension that is 48.6; 40.27; 48.9 in means “less sustainable”AbstractThe existence of fish fillet processing industries in Batang are able to have a positive impact on the surrounding community because it can create employment opportunities and increase community income. Therefore, it is necessary to know the importance of the sustainability of fish fillet processing industries to see the prospect of fishery business after a feasibility study. The aims of this study were to analyze the sustainability index value, determine the sensitive attributes of each dimension, and provide alternative management strategies of fish fillet processing industries in Batang. The method of analysis used was Rapfish method which is based on the technique of ordination by putting something measured using MDS on the program of Rapfish G77 Alscal program (VBA and Excel). Status management of fish fillet processing industries sustainability in Batang, which are multidimensionally sustainable, are 50.39. Whereas in other dimensions such as resources 58.20 (quite sustainable), economic 55.33 (fairly continuous), social 48.60 (less sustainable), legal and institutional 40.27 (less sustainable) and technological 48.90 (less sustainable). Based on this results, several management strategies should be prepared including increasing the capacity of government institutions, enhancing the role of fish fillet processing industry on society, increasing the application of technology and infrastructure, increasing the revenue of the entrepreneurs of fish fillet processing industry, preventing decline of quality and quantity of fish resources.
Characterization of chert in the Dammam Formation (Eocene), Kuwait: Clues to groundwater silicification processes
Authors: Khalaf Fikry Ibrahim , Thiry Médard , Milnes Anthony , Alnaqi Rehab 
Published: March 2020

ABSTRACTConspicuous chert horizons occur as discontinuous bands and isolated nodules in dolostones in the Eocene Dammam Formation, which is exposed in the southeast of Kuwait. The Formation has never been deeply buried, and so chert formation is likely to have resulted from silicification processes at or near the land surface. Erosional reworking of the chert constrains its formation to a time period between the late Eocene and the Mio-Pliocene. As there is no significant source of silica in the dolostones, the chert was formed from silica imported from other sources. This process, together with the specificity of chert to particular non-bedding horizons, suggests that silicification is related to discrete locations of the groundwater table during landscape incision and resultant groundwater discharge in the region. Detailed petrographical studies demonstrate that “chertification” was initiated by precipitation of nanoglobules of silica (opal-A) from supersaturated groundwater solutions flowing through voids formed concomitantly by dissolution of dolomite. Subsequently, silica was precipitated as more crystalline forms of chalcedony, microquartz, and megaquartz from successively less saturated groundwater. The most likely mechanism for triggering the precipitation of silica is considered to be significant cooling of the groundwater as it neared the landsurface and came into contact with a cold regolith terrain. Precipitation of disordered forms of silica (opal-A) occurred at the cold front: progressively more crystalline phases formed as the host rock was warmed by the inflowing groundwater and its degree of supersaturation diminished. If our interpretation is correct, this “chertification” process could have been initiated during global cooling related to one of the glaciations recorded during Oligocene and Miocene times.
Internet marketing organization with the use of intellegent and block chain technologies
Authors: Vishniakou U. A. 
Published: March 2020

The purpose of this work is to analyze methods, approaches, technologies, and means of Internet marketing (IM), using both known technologies and developing new ones: intellectual and blockchain. The objectives of the analysis are to identify trends in the development of Internet marketing in the digital economy with the use of intelligent and blockchain technologies, and to develop new structural solutions.The analysis of the use of intelligent technologies in marketing activities (MA) using cloud computing (CC) is carried out and its features are determined. Proposals have developed for improving Internet marketing in an integrated environment (traditional network and cloud one) using intelligent and blockchain technologies. It is proposed to develop IA on the basis of a family of intelligent agents for building intelligent marketing information systems (IMIS). The use of blockchain technology in IM for controlling resources and marketing operations is shown. A new concept for the development of IM and IIMS is presented, on the basis of which approaches to the organization of IMIS for communication between enterprises, research institutes and universities are developed. The structure of an intelligent portal based on multi-agent technology that unites developers and consumers of startups has been developed. Blockchain technology is used to control and guarantee the authorship of startups and signed contracts.As IM development trend, the development of models for joint activity of intelligent agents in the cloud environment to support decision-making using blockchain technology to legally secure the authorship of innovations is proposed. There are two areas of development of intelligent marketing systems: adaptation in digital markets and support for innovative activities with the consolidation of contracts based on blockchain technology.
A method for obtaining flexible broccoli varieties for sustainable agriculture
Authors: Ciancaleoni Simona , Negri Valeria 
Published: March 2020

Abstract
Background
The use of high inputs in agriculture has resulted in few varieties (hybrids and pure lines) used in all agricultural systems. Also varieties of vegetables, including broccoli , for organic and low-input agriculture, are almost exclusively hybrids, since there are very few specific breeding programs and varieties for sustainable agriculture systems .
A strategy to overcome this issue is the adoption of specific breeding programs for developing heterogeneous varieties (i.e. synthetics, open pollinated varieties, composite cross populations and mixtures). In fact, heterogeneous varieties are able to evolve and adapt to specific agro-climatic conditions.
The a im of this study was to develop a method (an Evolutionary Breeding Program, EBP) for obtaining heterogeneous varieties of broccoli and test its efficiency in developing highly diverse varieties, as needed in sustainable agriculture.
A synthetic variety originated from a landrace was multiplied in different environments for 3 cycles and morpho-phenological and genetic diversity of the derived populations were assessed.
Results
The presented result e d s presented are the first and unique indication about the efficiency of a short-time EBP for an allogamous species like broccoli.
Few morphological changes were observed among varieties multiplied in different environments with different agro-climatic conditions. This could be probably due to the initial genetic diversity of the landrace from which the populations were selected and also to the great plasticity of the crop. However, SSR data highlighted a genetic differentiation among populations multiplied for two/three years across Europe and in Central Italy , that was not so evident when considering morphological data only .
Conclusions
Few years of multiplication in different environments resulted in genetically differentiated broccoli populations that none the less preserved the original genetic diversity and productivity level and appear to evolve in relationship to different environments: the applied EBP is useful for developing heterogeneous materials for sustainable agriculture.
The effect of yoga on sleep quality and insomnia in women with sleep problems: a systematic review and meta-analysis
Authors: Wang Weili , Chen Kuang-Huei , Pan Ying-Chieh , Yang Szu-Nian , Chan Yuan-Yu 
Published: March 2020

Abstract
Background: To examine the effectiveness and safety of yoga of women with sleep problems by performing a systematic review and meta-analysis. Methods: Medline/PubMed, ClinicalKey, ScienceDirect, Embase, PsycINFO, and the Cochrane Library were searched throughout the month of June, 2019. Randomized controlled trials comparing yoga groups with control groups in women with sleep problems were included. Two reviewers independently evaluated risk of bias by using the risk of bias tool suggested by the Cochrane Collaboration for programming and conducting systematic reviews and meta-analyses. The main outcome measure was sleep quality or the severity of insomnia, which was measured using subjective instruments, such as the Pittsburgh Sleep QualityIndex (PSQI),Insomnia Severity Index (ISI), or objective instruments such as polysomnography, actigraphy, and safety of the intervention. For each outcome, a standardized mean difference (SMD) and confidence intervals (CIs) of 95% were determined. Results: Nineteen studies in this systematic review included 1832 participants. The meta-analysis of the combined data conducted according to Comprehensive Meta-Analysis showed a significant improvement in sleep (SMD =−0.327, 95% CI=−0.506 to −0.148,P<0.001).Meta-analyses revealed positive effects of yoga using PSQI scores in 16 randomized control trials (RCTs), compared with the control group in improving sleep quality among women usingPSQI (SMD = −0.54; 95% CI = −0.89 to −0.19; P = 0.003). However, three RCTs revealed no effects of yoga compared to the control groupin reducing insomnia among women using ISI (SMD = −0.13; 95% CI = −0.74 to 0.48; P = 0.69).Yoga was not associated with any serious adverse events. Discussion: This systematic review and meta-analysis demonstrated that yoga intervention in women can be beneficial whencompared to non-active control conditions in term of managing sleep problems.The moderator analyses suggest that participants in the non-breast cancer subgroup and participants in the non-peri/postmenopausal subgroup were associated with greater benefits, with a direct correlation of total class time with quality of sleep among other related benefits.
Evaluation of Microvascular Network with Optical Coherence Tomography Angiography (OCTA) in Branch Retinal vein Occlusion (BRVO)
Authors: Chen Lulu , Yuan Mingzhen , Sun Lu , Wang Yuelin , Chen Youxin 
Published: March 2020

Abstract
Purpose: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients.
Methods: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured.
Results: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes ( P <0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P <0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes ( P <0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes ( P <0.05). VD of inside disc in fellow eyes was lower than normal eyes ( P <0.05).
Conclusions: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions.
Key words: optical coherence tomography angiography, retinal vasculature, foveal avascular zone, radial peripapillary capillary, branch retinal vein occlusion
Mono-segment fixation method versus short-segment fixation methods, in treatment of mono-segmental lumbar tuberculosis; using titanium mesh cage with interbody fusion retrospective case-control study.
Authors: Zhang Hongqi , Manini Daudi Romani , Wang Yuxiang 
Published: March 2020

Abstract
Background: 1/3rd-2/3rd of the remaining vertebral height can hold and withstand the standard pedicle screws; some surgeons have adopted affected vertebral fixation to avoid the complications of both long and short segment fixation during surgical correction of lumbar tuberculosis (TB).This study aimed to compare efficacy of mono-segment-fixation versus the short-segment fixation methods with the use of titanium mesh-cage (TMCs) and interbody fusion in the treatment of mono-segmental lumbar spinal TB via single stage posterior-only approach. Methods ： A retrospective review was done among 34 lumbar spinal TB patients. These patients underwent debridement, interbody fusion with (TMCs) by either Mono-segment fixation or short-segment fixation methods. Eighteen patients underwent mono-segment fixation method, group (A). While 16 patients underwent short-segment fixation method, group (B). Fusion, deformity correction, and decompression were done within the affected segment in group (A), while for group (B) fusion extended one level above and below the affected vertebrae . Operation time, intra-operative blood loss, degree of deformity correction and neurological functions were analyzed. Results: Comparing group (A) vs (B), average operation time in minutes (mins) for group A was 144.2±16.5, group B was 170.3 ± 25.0 (P=0.001). Average intraoperative blood loss in milliliter (mls) was 502.8±151.9 for group (A) and 742.5±143.2 for group (B) (p ˂0.05). The mean cobb’s angle between group A versus group B; preoperative was 23.8 ± 6.5 0 vs 22.2±9.2 0 (p=0.6), immediate post operatively was 8.0±3.5 0 vs 8.3±5.7 0 (p=0.847) and at final follow-up was 8.9±3.1 0 vs 9.2 ± 5.9 0 (p=0.866) respectively. Correction rate between group (A) vs group (B) was 15.7±3.8 0 vs 13.9±5.5 0 (p=0.285) and loss of correction was 1.2±0.7 0 vs 1.1±0.7 (p=0.817) respectively. No significant differences in neurological recovery between the two groups were founds. Conclusion: Under precise conditions: mono-segment fixation method, debridement, interbody fusion with TMCs, and posterior instrumentation can effectively reconstruct the spine, maintain stability and correct kyphosis deformity similar to short-segment fixation method. Also, it can relieve pain and improve neurological symptoms. When used in combination with anti-TB chemotherapy in the treatment of mono-segmental lumbar TB via a single-stage posterior-only approach.
Coping with Wolf-Hirschhorn Syndrome: quality of life and psychosocial features of family carers
Authors: Berrocoso Sarah , Amayra Imanol , Lázaro Esther , Martínez Oscar , López-Paz Juan Francisco , García Maitane , Pérez Manuel , Al-Rashaida Mohammad , Rodríguez Alicia Aurora , Luna Paula Maria , Pérez-Núñez Paula , Blanco Raquel , Nevado Julián 
Published: March 2020

Abstract

Background : Wolf-Hirschhorn Syndrome (WHS) is a rare, congenital disease characterized by a distinctive facial phenotype, seizures, intellectual disability and developmental delay, and pre and postnatal growth requiring lifelong care. The psychosocial status of the family caregivers of children diagnosed with WHS is unknown. This study aims to characterize the sociodemographic and psychosocial profile of WHS caregivers and analyze how these variables impact their quality of life (QoL) and well-being. Results: The sociodemographic and clinical profile of 22 Spanish caregivers of children with WHS and the characteristics of those affected have been described. Significant relationships were found between sociodemographic and psychosocial characteristics among caregivers. The impact on the parents' QoL and negative relationship with the symptomatology were assessed. The use of engagement strategies such as problem focused coping was associated with improved psychological QoL and social support. Conclusions: WHS caregivers share similarities in their profile and needs with caregivers of children with other rare diseases. Pychosocial support groups involving parents caring for children with the same disease could improve caregivers’ well-being and QoL by strengthening their social support network and using positive coping styles. Keywords: Wolf-Hirschhorn syndrome; 4p deletion; caregivers; quality of life; coping; depression; social support; spirituality.
General practitioners’ management of patients with psychological stress: audit results from Denmark
Authors: Lykkegaard Jesper , Prior Anders , Rosendal Marianne 
Published: March 2020

Abstract

Background: In western countries, psychological stress is among the most common causes of long-lasting sick leave and a frequent reason to consult the general practitioner (GP). This study aimed to investigate how GPs manage patients with psychological stress and how the management is associated with the patient´s sex, the GP’s assessment of causality, and coexisting mental disorders. Methods: We conducted an audit of consecutive cases in Danish general practice. The GPs used electronic medical records to fill in a registration form for each 18-65-year-old patient with whom they had had at least one consultation regarding stress during the past six months. Only patients initially in the workforce were included. Age- and sex-adjusted binary regression was applied. Results: Fifty-six GPs (61% women) identified 785 cases. The patients’ mean age was 44 years and 69% were women. The cause of stress was considered at least partially work-related in 69% of the cases and multifactorial in a third of cases. The management included sick leave (54%), counselling (47%), pharmaceutical treatment (37%), and referral to psychologist (38%). Compared to women, stress in men was less often considered work-related ( RR: 0.84, CI95%: 0.77-0.92) and men were less often sick-listed (RR: 0.83 CI95%: 0.73-0.96) but were more often prescribed tranquilizers (RR: 1.72 CI95%: 1.08-2.74) . Conclusions: GPs’ management of patients with stress usually involve elements of counselling, sick leave, referral to psychologist, and medication. Women and men with stress are perceived of and managed differently.
Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: A systematic review and meta-analysis.
Authors: Zhao Jinlong , Huang Hetao , Liang Guihong , Zeng Ling-feng , Yang Weiyi , Liu Jun 
Published: March 2020

Abstract
Background Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of the intra-articular injection of PRP combined with HA compared with the intra-articular injection of PRP or HA alone in the treatment of KOA.Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Randomized controlled trials and cohort studies of PRP combined with HA for KOA were included. Two orthopaedic surgeons conducted the literature retrieval and extracted the data. Outcome indicators included the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Lequesne Index, the visual analogue scale (VAS) for pain, and adverse events (AEs). Review Manager 5.3 was used to calculate the relative risk (RR) or standardized mean difference (SMD) of the pooled data. STATA 14.0 was used for quantitative publication bias evaluation.Results Seven studies (5 randomized controlled trials, 2 cohort studies) with a total of 941 patients were included. In the VAS comparison after 6 months of follow-up, PRP combined with HA was more likely to reduce knee pain than PRP alone (SMD: -0.31; 95% confidence interval (CI): -0.55 to -0.06; P=0.01 < 0.05). PRP combined with HA for KOA achieved better improvements in the WOMAC Function Score (SMD: -0.32; 95% CI: -0.54 to -0.10; P < 0.05) and WOMAC Total Score (SMD: -0.42; 95% CI: -0.67 to -0.17; P < 0.05) at the 12-month follow-up than did the application of PRP alone. In a comparison of Lequesne Index scores at the 6-month follow-up, PRP combined with HA improved knee pain scores more than PRP alone (SMD: -0.42; 95% CI: -0.67 to -0.17; P < 0.05). In terms of AEs, PRP combined with HA was not significantly different from PRP or HA alone (P>0.05).Conclusions Compared with intra-articular injection of PRP alone, that of PRP combined with HA can improve the WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores. However, in terms of the incidence of AEs, PRP combined with HA is not significantly different from PRP or HA alone.