bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments
Authors: Wu Gang , Luo Yong , Guo Qian , Yang Mingming , Mahaman Yacoubou Abdoul Razak , Liu Yi , Wang Jian-Zhi , Liu Rong , Gao Xiang , Wang Xiaochuan 
Published: December 2024

Background To date, the effect of tau phosphorylation at different amino acid sites on the conformation and function of tau is still unclear in Alzheimer's disease (AD). Protein fingerprinting, also known as the protein folding shape code (PFSC) method, is a protein structure prediction technique based on protein sequence, which can reveal proteins’ most likely spatial conformation. Objective To investigate the effect of phosphorylation on tau protein conformation using PFSC technology and further analyze the differences in the effect of phosphorylation on tau aggregation at specific sites. Methods We performed a conformational analysis of wild-type and simulated mutant hTau441 using the PFSC method and synthesized the phosphorylated and non-phosphorylated tau fragments by the chemical solid phase method. Results We found that the number of Ser262 protein fingerprints increased from six in tau S262A to nine in tau S262E, together with increased conformational changes and enhanced flexibility. The in vitro Thioflavin S assay showed that phosphorylated tau fragments R1-pS262 possessed a stronger activity of inducing tau aggregation. In contrast to the non-phosphorylated tau fragment R1-nS262, R1-pS262 promoted endogenous tau aggregation and decreased synaptic proteins. In rats, R1-pS262 caused cognitive impairments and neuronal loss in addition to endogenous tau aggregation and synaptic damage. Conclusions Our study firstly reports that tau phosphorylation at Ser262 induces tau aggregation, and phosphorylated tau fragments R1-pS262 directly result in neuropathological changes. These provide new clues to the pathogenesis of tauopathy, such as AD, and a new molecular target for possible intervention.
Risk of long-term post-stroke dementia using a linked dataset of patients with ischemic stroke without a history of dementia
Authors: Kim Tae Jung , Lee Ji Sung , Oh Mi Sun , Park Soo-Hyun , Lee Kyungbok , Yu Kyung-Ho , Lee Byung-Chul , Yoon Byung-Woo , Ko Sang-Bae 
Published: December 2024

Background: Post-stroke dementia (PSD) is a common and disabling sequela of stroke. However, the long-term incidence of PSD after an ischemic stroke and factors which predict its occurrence are incompletely understood. Linkage of large health datasets is being increasing used to study long-term outcomes after disease. We used large-scale linked data from Korea to determine the long-term incidence of PSD after ischemic stroke, and identify which factors predicted its occurrence. Methods: From January 2008 to December 2014, patients with ischemic stroke ( n = 37,553) without a history of dementia were included in a linked dataset comprising the claims database of the Health Insurance Review and Assessment Service and the Clinical Research Center for Stroke registry data. The outcome measure was PSD after ischemic stroke. Clinical factors evaluated included vascular risk factors, acute stroke management including reperfusion therapy, antithrombotics, and statins, stroke severity, and educational levels, were evaluated. Results: Among 37,553 patients with ischemic stroke without a history of dementia (mean age: 64.9 years; 61.9% males), 6052 (16.1%) experienced PSD during a median follow-up period of 5 (interquartile range, 3.4–7.0) years. The 10-year estimated cumulative incidence of dementia was 23.5%. Age (hazard ratio (HR) 1.82 per 10 years, 95% confidence interval (CI) 1.75–1.88) and a lower educational level (illiteracy or no education HR 1.65 (CI = 1.44–1.88), 0–3 years 1.53 (CI = 1.31–1.79), 4–6 years 1.60 (CI = 1.43–1.80), 7–9 years 1.32 (CI = 1.16–1.49), 10–12 years 1.17 (CI = 1.04–1.32)) were independently associated with an elevated risk of PSD. Male sex was associated with a significantly lower risk of PSD (HR 0.86, CI = 0.79–0.92). Diabetes mellitus (HR 1.21, CI = 1.14–1.29), a history of stroke before index stroke (HR 1.31, CI = 1.21–1.41), and initial National Institutes of Health Stroke Scale (HR 1.03, CI = 1.03–1.04) were independent risk factors for PSD. Regarding medications, the use of anticoagulation and antipsychotic medications after stroke appeared to be associated with increased PSD risk, whereas statin therapy was associated with a reduced risk. Conclusions: PSD is common with a 5- and 10-year incidence in patients with ischemic stroke without a history of dementia of 16.1% and 23.5%, respectively. Factors associated with PSD include age, female sex, lower educational level, diabetes mellitus, initial stroke severity, antipsychotics, and anticoagulants. Further studies are required to determine whether reducing those risk factors which are treatable reduces the incidence of PSD.
Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis
Authors: Soares Caroline Almeida , Fiuza João Gouveia , Rodrigues Cláudio André Melo , Craveiro Nuno , Gil Pereira Júlio , Sousa Paula Cristina Ribeiro Fernandes , Martins Diana Catarina Pinto , Cancela Eugénia Maria , Ministro dos Santos Maria Paula 
Published: December 2024

Background: Morphological and functional cardiac involvement is rarely described in patients with inflammatory bowel disease (IBD) but there is evidence that they have an increased risk of cardiovascular (CV) events despite the lower prevalence of traditional CV risk factors. Objectives: Our systematic review and meta-analysis examined the relationship between IBD and cardiac function, namely the incidence of heart failure (HF) and subclinical echocardiographic changes. Data sources and methods: Two medical databases, PubMed and Scopus, were systematically searched up to September 2022 to identify all studies reporting HF and/or echocardiographic changes in IBD patients. Results: The qualitative analysis comprised a total of 18 studies (14 retrospective and 4 prospective studies) involving 59,838 patients. IBD was associated with subtle systolic and diastolic alterations, vascular dysfunction, increased risk for HF hospitalizations, and globally worse CV outcomes. Nine studies were included in the meta-analysis. In the IBD population, we found statistically significant reduced early to late diastolic transmitral flow (E/A), higher E to early diastolic mitral annular tissue velocity (E/e′), and decreased global longitudinal strain. Increased left atrial diameter and area were also present in IBD patients but no statistical significance was reached. Inter-atrial and right intra-atrial conduction delays were observed. Conclusion: The IBD population has an increased risk for left ventricular and atrial dysfunction, vascular changes, arrhythmias, and HF hospitalization. Screening with sensitive imaging like speckle tracking echocardiography could identify early subclinical changes. IBD is in fact a CV risk factor and tight inflammation control may reduce CV risk.
Return to Sport in Professional Athletes After Cartilage Restoration Surgery of the Knee: A Systematic Review and Meta-Analysis Demonstrates Gender Inequality and the Need for Improved Reporting
Authors: Kunze Kyle N. , Uzzo Robert N. , Thomas Zach D. , Hicks Justin , Rodeo Scott A. , Williams Riley J. 
Published: December 2024

Objective To synthesize the literature concerning return to sport (RTS) and related outcomes after cartilage restoration surgery of the knee in professional athletes. Design Cochrane, PubMed, and OVID/Medline databases were queried for data pertaining to RTS after knee cartilage surgery in professional athletes. Demographic information, cartilage lesion characteristics, and RTS-specific information were extracted. Freeman-Tukey Double-Arscine Transformations with Dersimonian-Laerd random-effects estimators were constructed to quantitatively describe the cumulative incidence of RTS, while heterogeneous data described narratively. Results Eleven studies (476 athletes; mean age 27.5 ± 2.1 years; 96.6% male) were included. Nine (81.8%) studies investigated a form of microfracture as treatment, with 6 (54.5%) performing isolated microfracture. The remaining studies investigated osteochondral allograft transplantation and mosaicplasty. More than half ( n = 6; 54.5%) did not report cartilage lesion location or size. The pooled RTS rate was 84.3% (95% CI: 75.4%-91.8%) at a mean 39.9 (range, 12-104) weeks postoperatively. In 6 studies reporting competition level, a trend toward returning to a lower than pre-injury level was observed. The definition of RTS was only provided in 6 (54.5%) studies, while the criteria for RTS was only reported in 2 (18.2%) studies, suggesting limited transparency. One study reported an objective imaging assessment of reparative tissue, while none reported formal RTS testing protocols or minimum RTS timeline. Conclusion Although the majority of professional athletes are reported to achieve a successful RTS after cartilage restoration surgery of the knee, the literature predominantly reflects microfracture treatment. Current limitations in this literature include a substantial lack of female representation and infrequent reporting of cartilage lesion characteristics, rehabilitation and RTS criteria, and objective imaging assessments of reparative tissue.
Effectiveness of caudal segmental mandibulectomy in a cat: clinical and tomographic outcomes
Authors: Pinna Stefania , Ciammaichella Luca , Tassani Chiara , Ferrari Chiara , Perfetti Simone 
Published: December 2024

Case summary A 1-year-old spayed female domestic British Shorthair cat was presented for facial trauma; there were multiple mandibular fractures involving the right temporomandibular joint (TMJ) that were managed conservatively. After 2 months, the owner reported a gradual onset of the cat’s inability to open its mouth and subsequent inappetence. The maximum mouth opening (MMO) measured 7 mm. CT showed ankylosis of the TMJ, and surgical treatment with caudal segmental mandibulectomy (CSM) was performed. The cat had a rapid postoperative recovery and returned promptly to spontaneous eating, with a nearly normal MMO of 33 mm. A CT scan performed 3 months postoperatively showed a mild rightward deviation of the mandible, and a clearly visible non-ossified ostectomy gap between the body and the ramus of the right mandible. The cat continued to eat spontaneously without dysphagia following surgery and was asymptomatic 1 year postoperatively. Relevance and novel information To the authors’ knowledge, this is the first report describing the tomographic findings after CSM, as compared with the clinical outcome. Postoperative CT is indicated to confirm the success of the procedure and to assess TMJ ankylosis sequalae or complications of the CSM surgical site at an early stage. This report confirmed the effectiveness of CSM in resolving TMJ stiffness due to articular fractures or ankylosis with a good clinical and tomographic outcome.
Are employee self-management and organizational self-management related to work engagement or burnout? Evidence from two studies
Authors: Morikawa Merit , Martela Frank , Hakanen Jari J 
Published: December 2024

Self-managing organizations, characterized by flat hierarchies and decentralized power, are expected to empower and engage employees. In contrast, critics argue that a lack of structure could cause confusion and increased stress and burnout. However, neither assumption has been quantitatively tested. Furthermore, the concept of self-management remains ambiguous, and validated scales have been lacking. Addressing this, we conducted two quantitative studies, one with employees from several organizations ( N = 425) and another with a nationally representative sample ( N = 2,000). First, we distinguish between organizational and employee self-management and develop validated scales for both. Next, we examine their relations to work engagement and burnout, finding that both types of self-management are positively related to work engagement and negatively to burnout. Both types of self-management were also indirectly related to work engagement and burnout via job challenges and job hindrances. Our study clarifies and quantifies what self-management is and suggests it can benefit employee well-being. JEL CLASSIFICATION: M12 Personnel Management
Insights into the Experiences of Persons with Substance Use Disorders During COVID-19 Lockdown in Lagos, Nigeria: A Qualitative Investigation
Authors: Adejoh Samuel Ojima , Osazuwa Peter , Busari-Akinbode Sofiat , Gborogen Rosilyn , Awodein Abolaji , Adisa Waziri , Tade Titi , Badru Fatai Adesina 
Published: December 2024

Objective: This study investigated the impact of COVID-19 lockdown on the consumption of illicit drugs among Persons with Substance Use Disorders in Lagos, Nigeria. Methods: Using convenience sampling, 25 participants, who use different substances consented to participate in the study. Data was collected using in-depth interview guide and thematically analysed using NVivo 12 Plus. Findings: The findings show that activities of celebrities on social media were motivation for use. There was an increase in the consumption of illicit drugs during the COVID-19 lockdown period among the participants. Participants were able to purchase illicit drugs from street vendors despite the lockdown restriction, while others bought from online retailers – the social media platforms. Participants reported an increase in the price of substances and a reduction in their quantity and quality during the lockdown which may likely account for the increase in consumption reported. Conclusion: The lockdown, though used in curtailing the spread of COVID-19, had an unintended increase in the consumption of illicit drugs suggesting that drug markets can be resilient and adaptive during global crises.
Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus
Authors: Lisewski Andreas Martin 
Published: December 2024

Abstract
Objectives
SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses. Recent evidence suggests that this site includes two additional functional motifs: a pat7 nuclear localization signal and two flanking O-glycosites. However, a systematic genus and subgenus analysis of spike protein sequences bearing this polyfunctional sequence domain has been missing.

Data description
Here we report comprehensive sequence data to demonstrate that among spike proteins of genus Betacoronavirus and outside of the SARS-CoV-2 clade a fully analogous S1/S2 domain was found in only one other virus: the artificial MERS infectious clone MERS-MA30, described already in 2017, which was rationally selected from serial passage in genetically humanized mice. As the evolutionarily closest betacoronaviruses outside of the SARS-CoV-2 clade lack all its three functional motifs, these data extend—beyond natural evolution and zoonosis—the current view on SARS-CoV-2 pre-pandemic origins by presenting the analogous S1/S2 MERS-MA30 sequence domain as a precise molecular blueprint for SARS-CoV-2.
A comprehensive review of microgrid challenges in architectures, mitigation approaches, and future directions
Authors: Punitha S. , Subramaniam N. P. , Vimal Raj P. Ajay D 
Published: December 2024

Abstract Microgrids (MGs) have the potential to be self-sufficient, deregulated, and ecologically sustainable with the right management. Additionally, they reduce the load on the utility grid. However, given that they depend on unplanned environmental factors, these systems have an unstable generation capacity. Central power system failures have persisted as a result of the microgrids' instability. Microgrid technology integration at the load level has been the main focus of recent research in the field of microgrids. The conventional power grids are now obsolete since it is difficult to protect and operate numerous interconnected distributed generators. A proper investigation of microgrid architectures is presented in this work. This research also explores deep investigations for the improvement of concerns and challenges in various power converter topologies with the aid of control strategies and communication techniques. This in-depth research is aimed at upgrading the appropriate power converter configuration to enhance sustainable growth in power quality, stability, and control over power sharing.
Relational Resonance and Content Creation
Authors: Song Tingting , Ho Yi-Chun (Chad) 
Published: December 2024

This study investigates how tie formation shapes the production of user-generated content on social media, offering insights into enhancing user engagement and alleviating social media fatigue. We conceptualize tie formation as a relationship codevelopment process involving a tie initiator and a respondent. Drawing on social psychology literature, we propose a framework that traces how initiators’ social cognition evolves throughout this process—from proactively extending an inviting social tie to receiving a responsive one in return. Central to our framework is a perceptual mechanism we term relational resonance, which fosters intrinsic motivation and prompts initiators to adjust their content creation. Using data from YouTube, we develop a Bayesian hierarchical model to identify individual creators’ content adjustments, measured by changes in video volume and viewer engagement. Our results reveal that while initiators tend to reduce content production after receiving a responsive tie, the videos they create generate higher engagement, with “like” and “subscribe” rates increasing by 1.1 and 2.9 percentage points, respectively. Remarkably, the receipt of a responsive tie leads to average weekly increases of 66 likes and 183 subscriptions even after accounting for the decrease in video volume, reinforcing the “quality over quantity” principle in content creation strategies. An online experiment further elucidates the mechanism underlying the observed adjustment behavior, providing robust validation for our proposed framework. Implications for research and practice are discussed. This paper was accepted by D.J. Wu, information systems. Funding: T. Song was supported by National Natural Science Foundation of China [Grants 71902114 and 72372101]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00830 .
New occurrences of Dasyprocta nigriclunis expands species distribution in Caatinga, northeast Brazil
Authors: Ribeiro Renan L. A. , Iack-Ximenes Gilson , Cherem José J. , Mozerle Hugo B. , Ferreira Matheus D. R. , Fernandes Jailton J. F. , Berlinck Christian N. 
Published: December 2024

Los límites entre las especies del género Dasyprocta aún están en debate y la distribución de las pacas también es incierta, especialmente en la Caatinga, donde D. prymnolopha y D. nigriclunis existen y hay discordancias sobre sí estos taxones deben ser sinonimizados o no. Esta nota tiene como objetivo reportar nuevos registros de D. nigriclunis obtenidos mediante el monitoreo con cámaras trampa, lo que amplía su área de distribución. El levantamiento de Dasyprocta se realizó en el Parque Nacional Catimbau, en el estado de Pernambuco, de junio de 2023 a julio de 2024, y en Dom Inocêncio, en el estado de Piauí, de enero de 2019 a junio de 2022. Las cámaras trampa se instalaron a ~40 cm del suelo, programadas para capturar 3 fotos a intervalos de un minuto entre ráfagas, y operaron 24 hr/día. Se utilizó un intervalo de 1 hr para definir registros independientes, ya que las especies de Dasyprocta suelen pasar largos períodos alimentándose frente a las cámaras. El gobierno brasileño, a través del Instituto Chico Mendes de Conservación de la Biodiversidad, reconoce y considera D. nigriclunis una especie válida. Así, reportamos 50 nuevos registros en 15 sitios de muestreo. Estos hallazgos amplían el rango geográfico de D. nigriclunis, mejoran los datos para la Evaluación del Riesgo de Extinción en Brasil, indican posibles sitios de recolección y destacan la necesidad de realizar inventarios de mamíferos en la Caatinga.
Meu encontro com Heliana
Authors: Esther Maria de Magalhães Arantes  
Published: December 2024

Como Heliana, nasci em 1949 e em julho de 2024, fiz 75 anos. Era o que ela faria também, poucos dias antes de mim, no mês de junho, caso não tivesse nos deixado prematuramente, em um triste 4 de março. Neste pequeno texto lembro das muitas vezes em que quase encontrei Heliana: ocasiões em que tivemos lado a lado, fazendo coisas muito parecidas, lendo os mesmos livros, circulando pelos mesmos lugares na companhia de amigos comuns e, finalmente, trabalhando na mesma universidade onde, afinal, nos encontramos.
Morbimortalidade por COVID-19 e a cobertura vacinal entre indígenas em um estado da Amazônia brasileira
Authors: Sousa Sandy Isabelly Osório de , Andrade Élida Fernanda Rêgo de , Silva Kalene Ramos , Caldas Rosinelle Janayna Coêlho , Trindade Lidiane de Nazaré Mota , Nogueira Laura Maria Vidal 
Published: December 2024

Objetivo: analisar a morbimortalidade por Covid-19 e a cobertura vacinal entre indígenas em um estado da Amazônia brasileira. Método: estudo epidemiológico, descritivo e de corte transversal, realizado com dados secundários de 8.197 dados de casos e óbitos por Covid-19 e da cobertura vacinal entre indígenas, correspondentes ao período de 2020 a 2022, no estado do Pará. Os dados são originados do Ministério da Saúde e foram analisados por meio de estatística descritiva, após aprovação pelo Comitê de Ética em Pesquisa. Resultados: o estudo apontou maior proporção de Covid-19 no sexo feminino (n=4.262; 51,99%), entre crianças (n=1.994; 24,32%), e maior número de óbitos na faixa etária de 71 a 80 anos (n=17; 32,69%). Houve baixa cobertura vacinal nos Distritos Sanitários Especiais Indígenas Rio Tapajós (n=4.653; 51,6%) e Kaiapó do Pará (n=2.177; 52,8%) referentes à primeira dose. Conclusão: houve aumento da mortalidade na maioria dos Distritos e baixa cobertura vacinal contra a Covid-19.
Condições facilitadoras e inibidoras na transição hospital-casa de crianças em tratamento do câncer hematológico
Authors: Vieira Thais Maia Teixeira , Silva Liliane Faria da , Góes Fernanda Garcia Bezerra , Nunes Michelle Darezzo Rodrigues , Malheiro Maria Isabel Dias da Costa , Moraes Juliana Rezende Montenegro Medeiros de 
Published: December 2024

Objetivo: analisar as condições facilitadoras e inibidoras na transição hospital-casa de crianças em tratamento do câncer hematológico. Método: estudo descritivo, qualitativo, desenvolvido com 20 familiares de crianças em tratamento de câncer hematológico, em um hospital pediátrico, no período de julho a outubro de 2023, sendo aprovado por comitê de ética em pesquisa das instituições proponentes e coparticipantes. Os dados foram processados pelo software IRAMUTEQ® e interpretados à luz da Teoria das Transições de Afaf Meleis. Resultados: as condições facilitadoras foram: fé, religiosidade, apoio e ajuda de familiares no cuidar e apoio escolar. O status socioeconômico, preconceito, isolamento social, sentimentos de medo e paralisação foram condições inibidoras da transição. Considerações finais: a transição hospital-casa de crianças com câncer é um período permeado por medo e incertezas, influenciado por condições facilitadoras e inibidoras.