bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between energy intensity and CO2 emissions: Does economic policy matter?
Authors: Danish  , Ulucak Recep , Khan Salah‐Ud‐Din 
Published: July 2020

AbstractIn an environment with economic policy uncertainty, the policies of energy efficiency are probably compromised due to weak regulation measures. Inconsistent economic policies may lead to higher energy consumption, which damages the environment. However, works of literature are silent on the role of economic policy uncertainty in carbon emission and energy nexus. Hence, the study is an attempt to investigate the role of economic policy uncertainty in the relationship between energy intensity and carbon dioxide (CO2) emissions in the United States by using annual data spanning from 1985 to 2017. A recent time series method proposed by Jordan and Philips (2018) is employed to get robust and consistent estimation results in the study. Empirical results reveal that (a) higher energy intensity contributes to pollution, (b) economic policy uncertainty adversely affects environmental quality, (c) economic policy uncertainty strengthens the detrimental effect of energy intensity on CO2 emissions.
Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos
Authors: Aksakal Feyza Icoglu , Sisman Turgay 
Published: July 2020

AbstractThe current study evaluates the adverse effects of Cu(OH)2 nanopesticide (CNPE) on the early life stages of zebrafish (Danio rerio). The developmental toxicity was determined using different parameters such as mortality (including LC50), hatching, heart rates, malformations, and alteration of the gene expressions. Zebrafish embryos (4 hpf‐hours postfertilization) were exposed to 1.0, 2.0, 4.0, 8.0, and 16.0 mg/l CNPE doses until 96 hpf. The 96 hours LC50 was recorded at 6.258 mg/l. Seventy‐two hpf total malformation index values for 2.0, 4.0, and 8.0 mg/l CNPE doses were 4.3, 7.2 and 7.9, respectively. 1.0 mg/l CNPE is not toxic for the zebrafish embryos/larvae. 2.0 to 8.0 CNPE doses caused some abnormalities in embryos/larvae morphology, including lack of body parts, tail deformities, chorda deformity, bubbled head, scoliosis, lordosis, weak or non‐pigmentation, decreased heart rate and larva length. 16.0 mg/l CNPE caused mortality in 72 hpf. The expression levels of seven immune system‐related genes (il‐1β, il‐8, cebp, tlr4, hsp70, NF‐kB, and mtf‐1) were examined. The transcription level of il‐1β, il‐8, tlr4, hsp70, and NF‐kB genes significantly increased in the CNPE exposure groups. While the expression of the mtf‐1 gene considerably decreased, the cebp gene expression level did not change in the 4.0 and 8.0 mg/l CNPE doses. In conclusion, CNPE could induce developmental toxicity with malformations in embryos/larvae and alter the gene expression.
Towards Programmable Chemistries
Authors: Flumini Dandolo , Weyland Mathias S. , Schneider Johannes J. , Fellermann Harold , Füchslin Rudolf M. 
Published: July 2020

AbstractWe provide a practical construction to map (slightly modified) GOTO-programs to chemical reaction systems. While the embedding reveals that a certain small fragment of the chemtainer calculus is already Turing complete, the main goal of our ongoing research is to exploit the fact that we can translate arbitrary control-flow into real chemical systems. We outline the basis of how to automatically derive a physical setup from a procedural description of chemical reaction cascades. We are currently extending our system in order to include basic chemical reactions that shall be guided by the control-flow in the future.
Studying and Simulating the Three-Dimensional Arrangement of Droplets
Authors: Schneider Johannes Josef , Weyland Mathias Sebastian , Flumini Dandolo , Matuttis Hans-Georg , Morgenstern Ingo , Füchslin Rudolf Marcel 
Published: July 2020

AbstractWe present some work in progress on the development of a probabilistic chemical compiler, being able to make a plan of how to create a three-dimensional agglomeration of artificial hierarchical cellular constructs. These programmable discrete units offer a wide variety of technical innovations, like a portable biochemical laboratory being able to e.g. produce macromolecular medicine on demand, and of scientific investigations, like contributions to questions regarding the origin of life. This paper focuses on one specific issue of developing such a compiler, namely the problem of simulating the experimentally observed spatial transition from an originally one-dimensional lineup of droplets into a three-dimensional, almost spherical arrangement, in which the droplets form a network via bilayers connecting them and in which they are contained within some outer hull. The network created by the bilayers allows the droplets to “communicate” (like agents in a multi agent system) with each other and to exchange chemicals contained within them, thus enabling a complex successive biochemical reaction scheme.
Investigating Three-Dimensional Arrangements of Droplets
Authors: Schneider Johannes Josef , Weyland Mathias Sebastian , Flumini Dandolo , Füchslin Rudolf Marcel 
Published: July 2020

AbstractWe present some work in progress on the development of a small portable biochemical laboratory, in which spatially structured chemical reaction chains in a microfluidic setting shall be created on demand. For this purpose, hierarchical three-dimensional agglomerations of artificial cellular constructs are generated which will allow for a governed gradual reaction scheme leading e.g. to desired macromolecules. In this paper, we focus on the task of investigating the bilayer networks via which the chemical reactions are performed, both from experiment and from simulation.
CAS-FGOALS Datasets for the Two Interglacial Epochs of the Holocene and the Last Interglacial in PMIP4
Authors: Zheng Weipeng , Yu Yongqiang , Luan Yihua , Zhao Shuwen , He Bian , Dong Li , Song Mirong , Lin Pengfei , Liu Hailong 
Published: July 2020

AbstractTwo versions of the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System model (CAS-FGOALS), version f3-L and g3, are used to simulate the two interglacial epochs of the mid-Holocene and the Last Interglacial in phase 4 of the Paleoclimate Modelling Intercomparison Project (PMIP4), which aims to study the impact of changes in orbital parameters on the Earth’s climate. Following the PMIP4 experimental protocols, four simulations for the mid-Holocene and two simulations for the Last Interglacial have been completed, and all the data, including monthly and daily outputs for the atmospheric, oceanic, land and sea-ice components, have been released on the Earth System Grid Federation (ESGF) node. These datasets contribute to PMIP4 and CMIP6 (phase 6 of the Coupled Model Intercomparison Project) by providing the variables necessary for the two interglacial periods. In this paper, the basic information of the CAS-FGOALS models and the protocols for the two interglacials are briefly described, and the datasets are validated using proxy records. Results suggest that the CAS-FGOALS models capture the large-scale changes in the climate system in response to changes in solar insolation during the interglacial epochs, including warming in mid-to-high latitudes, changes in the hydrological cycle, the seasonal variation in the extent of sea ice, and the damping of interannual variabilities in the tropical Pacific. Meanwhile, disagreements within and between the models and the proxy data are also presented. These datasets will help the modeling and the proxy data communities with a better understanding of model performance and biases in paleoclimate simulations.
Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications
Authors: Akobeng Anthony K. , Singh Parul , Kumar Manoj , Al Khodor Souhaila 
Published: July 2020

Abstract
Purpose
Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disease. This review aims to provide an overview of the available data on the potential mechanisms through which the gut microbiota plays a role in the causation of coeliac disease and to discuss the potential therapeutic strategies that could diminish the consequences of microbial dysbiosis.

Method
A search of the literature was performed using the PubMed, Embase, and JSTOR databases; relevant articles were included.

Results
Recent studies in patients with coeliac disease have reported an increase in the relative amounts of gram negative bacterial genera such as Bacteroides, Prevotella, and Escherichia, and reduced amounts of protective anti-inflammatory bacteria such as Bifidobacteria and Lactobacilli. Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. In infancy, antibiotic use and certain infant feeding practices may lead to alterations in the developing gut microbiota to influence the immune maturation process and predispose to coeliac disease.

Conclusion
The induction of the intestinal immune system and gluten intolerance may be influenced by the relative abundance of certain microbiota. Factors such as infant feeding practices, diet, antibiotics, and infections, may be involved in the development of coeliac disease due to their influence on gut microbial composition. The efficacy of potential modulators of the gut microbiota such as probiotics, prebiotics, and fecal microbial transplant as adjunctive treatments to gluten-free diet in coeliac disease is unproven and requires further investigation.
Trust in farm data sharing: reflections on the EU code of conduct for agricultural data sharing
Authors: van der Burg Simone , Wiseman Leanne , Krkeljas Jovana 
Published: July 2020

AbstractDigital farming technologies promise to help farmers make well-informed decisions that improve the quality and quantity of their production, with less labour and less impact on the environment. This future, however, can only become a reality if farmers are willing to share their data with agribusinesses that develop digital technologies. To foster trust in data sharing, in Europe the EU Code of Conduct for agricultural data sharing by contractual agreement was launched in 2018 which encourages transparency about data use. This article looks at the EU Code through the lens of literature on trust and contract agreements. We agree with the makers of the EU Code that a contract can make an important contribution to trust relationships as it is needed to mitigate the detrimental effects of power relationships between experts and non-experts. Building on Onora O’Neills perspective to trust, however, we argued that a contract can only be successful in fostering trust when (a) information is comprehended by the more vulnerable party in this relationship who has to sign the contract, (b) the more powerful partner takes responsibility to provide that information, and (c) information is tailored to the information needs of the party signing the contract, even when data are re-used over a longer period. In addition, we think that differences between trust relationships and relationships of accountability, give reason to add to informed consent other more substantive ethical components in a more encompassing code of conduct.
Hybrid transnational advocacy networks in environmental protection: banning the use of cyanide in European gold mining
Authors: Bocse Alexandra-Maria 
Published: July 2020

AbstractThis paper contributes theoretically, empirically and methodologically to the literature on transnational advocacy networks (TANs). This study is guided by two associated research questions: ‘How are TANs structured?’ and ‘What relation is established between the TANs’ structure and their efficiency?’ The paper shows that environmental transnational advocacy networks are not as horizontal as assumed in the TANs literature. Elements of hierarchy are present in networks through highly connected and/or strategically positioned nodes. This paper shows that elements of hierarchy are introduced in networks to facilitate information exchange and decision-making. The paper studies for the first time the TAN advocating the ban of cyanide-based mining in Europe in the late 2000s–early 2010s. The network aimed to impact the EU environmental legislative framework, as well as contribute to the implementation of international agreements on pollution prevention and biodiversity protection. This study draws on extensive fieldwork (including interviews with forty-five members of the network) conducted in several European countries in which the network developed and maintains branches. The study innovates methodologically by combining content analysis and social network analysis in the process of determining the more central actors of the network studied.
Hormonal response of Acutodesmus obliquus exposed to combined treatment with 24-epibrassinolide and lead
Authors: Talarek-Karwel Marta , Bajguz Andrzej , Piotrowska-Niczyporuk Alicja 
Published: July 2020

AbstractPhytohormones play key roles in many aspects of plant growth and development, as well as in resistance to abiotic stresses. The presence of heavy metal limits phytohormone endogenous level; however, the application of brassinosteroids (BRs) restores phytohormone homeostasis and reduces unfavorable consequences of heavy metal on plant growth. Therefore, the aim of this study was to (1) broaden previously published analyses/findings to study the effect of 24-epibrassinolide (EBL) and/or lead (Pb) on Acutodesmus obliquus phytohormone level after 5 days of cultivation using LC-QToF-MS quantification technique and (2) extend the total amount of quantified phytohormones in A. obliquus. The study confirmed that exogenous EBL increased the contents of gibberellin A3 (GA3), auxins (AXs) (indole-3-acetic acid, phenylacetic acid), BRs brassinolide, 24-epibrassinolide (EBL), 28-homobrassinolide, castasterone, 24-epicastasterone, typhasterol, cathasterone, 6-deoxotyphasterol, as well as different types of cytokinins (CKs): free bases, ribosides, and conjugates (N- and O-glucosides). On the other hand, treatment with Pb had an opposite effect on BRs, GA3, AXs, and free bases, as well as ribosides of CKs. The abscisic acid (ABA) level decreased under EBL treatment but increased in response to Pb stress. The level of N-glucosides, as well as O-glucosides of CKs, also significantly increased in response to Pb alone. Interestingly, the co-application of EBL and Pb led to an increase in BRs, GA3, AXs, and CKs content in the algae. Principal component analysis revealed that based on treatments, increase of GA3, BRs, and AXs was found to be in the following order: 1 μM EBL > 0.01 μM Pb + 1 μM EBL > 500 μM Pb + 1 μM EBL > control > 0.01 μM Pb > 500 μM Pb. Moreover, very strong significant linear relations between almost all studied AXs and BRs were noted. Summarizing, this research did not only allow to detect the occurrence of ABA, GA3, AXs, BRs, and CKs in A. obliquus for the first time but also to study the combined action of EBL and Pb, as well as compare it with treatment alone.
Using an implementation science approach to implement and evaluate patient-reported outcome measures (PROM) initiatives in routine care settings
Authors: Stover Angela M. , Haverman Lotte , van Oers Hedy A. , Greenhalgh Joanne , Potter Caroline M. ,   On behalf of the ISOQOL PROMs/PREMs in Clinical Practice Implementation Science Work Group, Ahmed Sara , Greenhalgh Joanne , Gibbons Elizabeth , Haverman Lotte , Manalili Kimberly , Potter Caroline , Roberts Natasha , Santana Maria , Stover Angela M. , van Oers Hedy 
Published: July 2020

Abstract
Purpose
Patient-reported outcome and experience measures (PROMs/PREMs) are well established in research for many health conditions, but barriers persist for implementing them in routine care. Implementation science (IS) offers a potential way forward, but its application has been limited for PROMs/PREMs.

Methods
We compare similarities and differences for widely used IS frameworks and their applicability for implementing PROMs/PREMs through case studies. Three case studies implemented PROMs: (1) pain clinics in Canada; (2) oncology clinics in Australia; and (3) pediatric/adult clinics for chronic conditions in the Netherlands. The fourth case study is planning PREMs implementation in Canadian primary care clinics. We compare case studies on barriers, enablers, implementation strategies, and evaluation.

Results
Case studies used IS frameworks to systematize barriers, to develop implementation strategies for clinics, and to evaluate implementation effectiveness. Across case studies, consistent PROM/PREM implementation barriers were technology, uncertainty about how or why to use PROMs/PREMs, and competing demands from established clinical workflows. Enabling factors in clinics were context specific. Implementation support strategies changed during pre-implementation, implementation, and post-implementation stages. Evaluation approaches were inconsistent across case studies, and thus, we present example evaluation metrics specific to PROMs/PREMs.

Conclusion
Multilevel IS frameworks are necessary for PROM/PREM implementation given the complexity. In cross-study comparisons, barriers to PROM/PREM implementation were consistent across patient populations and care settings, but enablers were context specific, suggesting the need for tailored implementation strategies based on clinic resources. Theoretically guided studies are needed to clarify how, why, and in what circumstances IS principles lead to successful PROM/PREM integration and sustainability.
Is drawing after learning effective for metacognitive monitoring only when supported by spatial scaffolds?
Authors: Kollmer Julia , Schleinschok Katrin , Scheiter Katharina , Eitel Alexander 
Published: July 2020

AbstractIn this study, we investigated whether drawing after learning supports metacognitive monitoring especially when students are supported in their drawing efforts. Therefore, eighty-eight participants were randomly assigned to one of three experimental groups. They were asked to learn from a text comprising five paragraphs about the formation of auroras. After reading each of the five paragraphs, one group had to mentally imagine the contents (control group), a second group had to draw from scratch, and a third group had to draw with the help of spatial scaffolds. All participants provided judgments of learning (JOL) for each paragraph, and took a knowledge test afterwards. Results revealed that students who drew, both with and without scaffold, monitored their learning more accurately on an absolute level. Even though there were no differences between the two drawing conditions for monitoring accuracy, JOLs were based on the actual drawing quality only when students drew with the help of spatial scaffolds. Results thus hint towards the potential of (scaffolded) drawing to support metacognitive monitoring. Reasons for why drawing with spatial scaffolds did not improve monitoring compared to drawing from scratch are discussed.
Pandemics and food systems - towards a proactive food safety approach to disease prevention & management
Authors: Aiyar Anaka , Pingali Prabhu 
Published: July 2020

AbstractRecent large-scale pandemics such as the covid19, H1N1, Swine flu, Ebola and the Nipah virus, which impacted human health and livelihoods, have come about due to inadequate food systems safeguards to detect, trace and eliminate threats arising from zoonotic diseases. Such diseases are transmitted to humans through their interaction with animals in the food value chain including through the consumption of bush meat. Climate change has also facilitated the emergence of new zoonotic diseases. The lack of adequately enforced food-safety standards in managed agricultural production systems creates the necessary conditions for diseases to mutate into highly contagious strains. The lack of food safety measures in handling, packaging and sales of food increases risks of cross-species contamination. Finally, increasing anti-microbial resistance, combined with rapid urbanization and global interconnectedness allows diseases to spread rapidly among humans. Thus, part of the reconstruction efforts, post covid19, should include prioritizing proactive investments in food safety. The key to stave off another such pandemic lies in integrating one-health knowledge on zoonotic diseases along with food safety measures along the food value chain. Refocusing policy priorities from disease control to prevention will improve international coordination efforts in pandemic prevention. Implementing such proactive actions will cost a very small fraction of the reconstruction budgets. However, the expected benefits of the food-safety approach will include preventing global economic losses due to pandemics.
Resilience of local food systems and links to food security – A review of some important concepts in the context of COVID-19 and other shocks
Authors: Béné Christophe 
Published: July 2020

AbstractThe objective of this review is to explore and discuss the concept of local food system resilience in light of the disruptions brought to those systems by the 2020 COVID-19 pandemic. The discussion, which focuses on low and middle income countries, considers also the other shocks and stressors that generally affect local food systems and their actors in those countries (weather-related, economic, political or social disturbances). The review of existing (mainly grey or media-based) accounts on COVID-19 suggests that, with the exception of those who lost members of their family to the virus, as per June 2020 the main impact of the pandemic derives mainly from the lockdown and mobility restrictions imposed by national/local governments, and the consequence that the subsequent loss of income and purchasing power has on people’s food security, in particular the poor. The paper then uses the most prominent advances made recently in the literature on household resilience in the context of food security and humanitarian crises to identify a series of lessons that can be used to improve our understanding of food system resilience and its link to food security in the context of the COVID-19 crisis and other shocks. Those lessons include principles about the measurement of food system resilience and suggestions about the types of interventions that could potentially strengthen the abilities of actors (including policy makers) to respond more appropriately to adverse events affecting food systems in the future.
Who Creates a Google Scholar Profile?
Authors: Kim Hannah June , Grofman Bernard 
Published: July 2020

ABSTRACTThis article uses data collected from Google Scholar to identify characteristics of scholars who have chosen to create a Google Scholar profile. Among tenured and tenure-track faculty with full-time appointments in PhD-granting political science departments, we find that only 43.7% have created a profile. However, among R1 faculty, young and early-career faculty are more likely to have Google Scholar profiles than those in older cohorts. Although subfield differences are largely nonexistent, there is a notably low proportion of theory faculty with profiles and a slightly higher proportion with profiles among methodologists. Moreover, within cohorts, those who are highly cited are more likely to have profiles than those who have low citation counts. We conclude by discussing implications of our findings, the increasing usage of Google Scholar and profiles, and the increasing importance of an online presence in the academy.