bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term results of ERCP- or PTCS-directed photodynamic therapy for unresectable hilar cholangiocarcinoma
Authors: Li Zongyan , Jiang Xiaofeng , Xiao Hua , Chen Shaoyi , Zhu Wenfeng , Lu Haiwu , Cao Liangqi , Xue Ping , Li Haiyan , Zhang Dawei 
Published: October 2020

Abstract
Background
Photodynamic therapy (PDT) can be performed as palliative therapy for cholangiocarcinoma, while there is currently insufficient evidence for the efficacy. The aim of this study was to explore the clinical efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement for unresectable hilar cholangiocarcinoma.

Methods
A retrospective analysis was conducted on 62 patients with unresectable hilar cholangiocarcinoma. Thirty patients received PDT using hematoporphyrin combined with biliary stent placement (PDT+stent group), including 22 receiving ERCP-directed PDT and 8 receiving PTCS-directed PDT. Survival time, quality of life, and postoperative adverse events were compared to 32 patients receiving biliary stent placement alone (Stent-only group).

Results
After 42 months of follow-up, median survival time was significantly longer in the PDT+stent group than the Stent-only group (14.2 vs. 9.8 months, P = 0.003). In the PDT+stent group, the median survival time was longer in the 6 patients with recurrence after surgical resection than the 24 patients without prior surgical resection (20.0 vs. 13.0 months, P = 0.017). The QOL total scores was significantly higher in the PDT+stent group than the Stent-only group at postoperative 6, 9, and 12 months (P<0.05). There was no significant difference in the incidence of postoperative adverse events between the two groups (24 [38.7%] vs. 20 [29.0%], P = 0.239).

Conclusion
ERCP- or PTCS-directed PDT + stent placement can prolong the survival of patients with unresectable hilar cholangiocarcinoma, especially those with recurrence and improve quality of life without increasing adverse events.
The learning curve of TaTME for mid-low rectal cancer: a comprehensive analysis from a five-year institutional experience
Authors: Persiani Roberto , Agnes Annamaria , Belia Francesco , D’Ugo Domenico , Biondi Alberto 
Published: October 2020

Abstract
Background
Transanal total mesorectal excision (TaTME) was introduced in 2009 as a dedicated approach for the treatment of mid-low rectal cancer. We aimed to describe and discuss the learning curve for 121 consecutive TaTME procedures performed by the same team.

Methods
The primary outcome was the number of operations required to decrease the mean operative time (mOT). The secondary outcomes were the number of operations required to decrease the major complication (MC) rate, the anastomotic leakage (AL) rate, the clinical anastomotic failure rate, and the reoperation rate. A cumulative sum (CUSUM) curve analysis was used to identify the inflection points. As an integrative analysis, Bernoulli CUSUM curves, risk-adjusted CUSUM curves based on the observed-expected outcomes, and CUSUM curves targeting results reported in the literature were created.

Results
Seventy-one cases were needed to overcome the OT learning curve sufficiently to reach mastery. The MC and reoperation rates started to decrease after the 54th case and further decreased after the 69th case. The AL rate started to decrease after the 27th case and remained stable at 5–5.1%. The comparison between the different phases of the learning curves confirmed these turning points.

Conclusions
TaTME had a learning curve of 71 cases for the mOT, 55–69 cases for MCs and reoperation, and 27 cases for AL. According to our results, attention should be paid during the first part of the learning curve to avoid an increased rate of MCs and AL.
High-intensity interval training in the prehabilitation of cancer patients—a systematic review and meta-analysis
Authors: Palma Stefano , Hasenoehrl Timothy , Jordakieva Galateja , Ramazanova Dariga , Crevenna Richard 
Published: October 2020

Abstract
Purpose
To evaluate the impact of high-intensity interval training (HIIT) on health-related outcome parameters in the prehabilitation of patients diagnosed with cancer.

Methods
A systematic review and meta-analysis of comparative studies on HIIT in cancer prehabilitation conducted by screening standard databases from their inception to March 30, 2020. Outcomes of interest included cardiorespiratory fitness, feasibility, safety, clinical, and patient-reported outcomes.

Results
Of the 855 identified studies, 8 articles met the inclusion criteria (7 randomized, 1 non-randomized controlled trial) with a total of 896 patients. The study protocols were heterogeneous, but the methodological quality ranged from good to high according to PEDro scale. Meta-analysis revealed a significant improvement of peak oxygen consumption (VO2peak) achieved with HIIT compared to usual care. Furthermore, HIIT was feasible and safe, showing low risk of adverse events and positive effects on health-related outcomes in prehabilitative settings.

Conclusion
In the phase of prehabilitation, HIIT has potential health benefits in patients diagnosed with cancer and is feasible and safe to perform. Nonetheless, larger randomized controlled trials focusing on long-term effects (such as cancer recurrence or survival rates) are missing, to underline the potential relevance of HIIT for cancer patients.
Impact of clinical and psychological factors associated with depression in patients with rheumatoid arthritis: comparative study between Germany and Brazil
Authors: Morf Harriet , da Rocha Castelar-Pinheiro Geraldo , Vargas-Santos Ana Beatriz , Baerwald Christoph , Seifert Olga 
Published: October 2020

Abstract
Objective
To investigate the prevalence of depressive symptoms and its association with clinical and psychological factors in patients with rheumatoid arthritis (RA) in Germany and in Brazil.

Method
A convenience sample of 267 RA patients, 176 from Germany (age 62.4 ± 12.3 years) and 91 from Brazil (age 56.3 ± 12.6 years), was used in this cross-sectional study. The following questionnaires were used: Beck Depression Inventory (BDI), painDETECT test, Perceived Stress Questionnaire, fatigue questionnaire (FACIT), Health Assessment Questionnaire Disability Index (HAQ-DI), and the SF–36 questionnaires (Short-Form 36 Health Survey). Disease activity score (DAS 28-CRP) and visual analogue scale (VAS) for pain were also evaluated. Statistical analysis is based on comparison of means and proportions. Statistical significance for non-normal data was evaluated by non-parametrical tests.

Results
Depressive symptoms were more prevalent in the Brazilian sample (44% vs 22.9%, p = 0.025). Compared to German patients, the Brazilian ones also experienced more pain (current pain status on VAS: 4.67 ± 3.4 vs 3.67 ± 2.31 respectively, p < 0.01), were physically more limited (1.89 ± 1.85 vs 1.01 ± 0.75, p = 0.012), and had higher C-reactive protein levels (7.78 ± 18.3 vs 5.82 ± 10.45, p = 0.028). Despite receiving a more intensive treatment, German patients presented similar disease activity when compared to Brazilian patients (DAS28-CRP: Brazil 3.4 ± 1.5 vs Germany 3.3 ± 1.3, p = 0.307).

Conclusion
Depressive symptoms are frequent in RA patients from different countries and interact with psychological disorders and the experience of pain. They contribute negatively to their well-being suggesting the need for psychoeducational strategies.

Key Points• New psychoeducational strategies for RA management.• Higher inflammation marker in rheumatoid arthritis patients is associated with depression.• Medical treatment in RA influences depressive symptoms.• Depressive symptoms are dependent on population group.• High disease activity is related to depression.
Ablative laser surgery for allergic tattoo reactions: a retrospective study
Authors: van der Bent S. A. S. , Huisman Sanne , Rustemeyer T. , Wolkerstorfer A. 
Published: October 2020

AbstractPatients with allergic tattoo reactions are burdened with itch and have a reduced quality of life. Conservative treatment is often insufficient and little is known about treatment options to remove the responsible allergen. We aimed to address the effectiveness and safety of ablative laser therapy including measurement of patient’s satisfaction, in patients with allergic reactions to tattoos. A retrospective study was conducted including patients with allergic tattoo reactions who were treated with a 10,600 nm ablative CO2laser, either by full-surface ablation or fractional ablation. Clinical information originated from medical files and a 25-item questionnaire. Sixteen tattoo allergy patients were treated with a CO2laser between January 2010 and January 2018. Fourteen patients completed the questionnaire. Ten patients were satisfied with laser treatment. On a visual analogue scale, pruritus and burning improved with a median of 5.5 and 4 points in the full surface ablation group and 3 points on both parameters in the fractional ablation group. Despite the relatively small group of patients, our results suggest that CO2laser ablation improves itching, burning and impact on daily life in tattoo allergy.
Quinn’s Formula and Abelian 3-Cocycles for Quadratic Forms
Authors: Braunling Oliver 
Published: October 2020

AbstractIn pointed braided fusion categories knowing the self-symmetry braiding of simples is theoretically enough to reconstruct the associator and braiding on the entire category (up to twisting by a braided monoidal auto-equivalence). We address the problem to provide explicit associator formulas given only such input. This problem was solved by Quinn in the case of finitely many simples. We reprove and generalize this in various ways. In particular, we show that extra symmetries of Quinn’s associator can still be arranged to hold in situations where one has infinitely many isoclasses of simples.
Study on on-Chip Antenna Design Based on Metamaterial-Inspired and Substrate-Integrated Waveguide Properties for Millimetre-Wave and THz Integrated-Circuit Applications
Authors: Alibakhshikenari Mohammad , Virdee Bal S. , Althuwayb Ayman Abdulhadi , Aïssa Sonia , See Chan H. , Abd-Alhameed Raed A. , Falcone Francisco , Limiti Ernesto 
Published: October 2020

AbstractThis paper presents the results of a study on improving the performance parameters such as the impedance bandwidth, radiation gain and efficiency, as well as suppressing substrate loss of an innovative antenna for on-chip implementation for millimetre-wave and terahertz integrated-circuits. This was achieved by using the metamaterial and the substrate-integrated waveguide (SIW) technologies. The on-chip antenna structure comprises five alternating layers of metallization and silicon. An array of circular radiation patches with metamaterial-inspired crossed-shaped slots are etched on the top metallization layer below which is a silicon layer whose bottom surface is metalized to create a ground plane. Implemented in the silicon layer below is a cavity above which is no ground plane. Underneath this silicon layer is where an open-ended microstrip feedline is located which is used to excite the antenna. The feed mechanism is based on the coupling of the electromagnetic energy from the bottom silicon layer to the top circular patches through the cavity. To suppress surface waves and reduce substrate loss, the SIW concept is applied at the top silicon layer by implementing the metallic via holes at the periphery of the structure that connect the top layer to the ground plane. The proposed on-chip antenna has an average measured radiation gain and efficiency of 6.9 dBi and 53%, respectively, over its operational frequency range from 0.285–0.325 THz. The proposed on-chip antenna has dimensions of 1.35 × 1 × 0.06 mm3. The antenna is shown to be viable for applications in millimetre-waves and terahertz integrated-circuits.
Effect of an Electronic Health Record “Nudge” on Opioid Prescribing and Electronic Health Record Keystrokes in Ambulatory Care
Authors: Ancker Jessica S. , Gossey J. Travis , Nosal Sarah , Xu Chenghuiyun , Banerjee Samprit , Wang Yuming , Veras Yulia , Mitchell Hannah , Bao Yuhua 
Published: October 2020

AbstractBackgroundMultiple policy initiatives encourage more cautious prescribing of opioids in light of their risks. Electronic health record (EHR) redesign can influence prescriber choices, but some redesigns add to workload.ObjectiveTo estimate the effect of an EHR prescribing redesign on both opioid prescribing choices and keystrokes.DesignQuality improvement quasi-experiment, analyzed as interrupted time series.ParticipantsAdult patients of an academic multispecialty practice and a federally qualified health center (FQHC) who received new prescriptions for short-acting opioids, and their providers.InterventionIn the redesign, new prescriptions of short-acting opioids defaulted to the CDC-recommended minimum for opioid-naïve patients, with no alerts or hard stops, such that 9 keystrokes were required for a guideline-concordant prescription and 24 for a non-concordant prescription.Main MeasuresProportion of guideline-concordant prescriptions, defined as new prescriptions with a 3-day supply or less, calculated per 2-week period. Number of mouse clicks and keystrokes needed to place prescriptions.Key ResultsAcross the 2 sites, 22,113 patients received a new short-acting opioid prescription from 821 providers. Before the intervention, both settings showed secular trends toward smaller-quantity prescriptions. At the academic practice, the intervention was associated with an immediate increase in guideline-concordant prescriptions from an average of 12% to 31% of all prescriptions. At the FQHC, about 44% of prescriptions were concordant at the time of the intervention, which was not associated with an additional significant increase. However, total keystrokes needed to place the concordant prescriptions decreased 62.7% from 3552 in the 6 months before the intervention to 1323 in the 6 months afterwards.ConclusionsAutocompleting prescription forms with guideline-recommended values was associated with a large increase in guideline concordance in an organization where baseline concordance was low, but not in an organization where it was already high. The redesign markedly reduced the number of keystrokes needed to place orders, with important implications for EHR-related stress.Trial Registrationwww.ClinicalTrials.gov protocol 1710018646
Fatou’s Associates
Authors: Evdoridou Vasiliki , Rempe Lasse , Sixsmith David J. 
Published: October 2020

AbstractSuppose thatfis a transcendental entire function,$$V \subsetneq {\mathbb {C}}$$V⊊Cis a simply connected domain, andUis a connected component of$$f^{-1}(V)$$f-1(V). Using Riemann maps, we associate the map$$f :U \rightarrow V$$f:U→Vto an inner function$$g :{\mathbb {D}}\rightarrow {\mathbb {D}}$$g:D→D. It is straightforward to see thatgis either a finite Blaschke product, or, with an appropriate normalisation, can be taken to be an infinite Blaschke product. We show that when the singular values offinVlie away from the boundary, there is a strong relationship between singularities ofgand accesses to infinity inU. In the case whereUis a forward-invariant Fatou component off, this leads to a very significant generalisation of earlier results on the number of singularities of the mapg. IfUis a forward-invariant Fatou component offthere are currently very few examples where the relationship between the pair (f, U) and the functionghas been calculated. We study this relationship for several well-known families of transcendental entire functions. It is also natural to ask which finite Blaschke products can arise in this manner, and we show the following: for every finite Blaschke productgwhose Julia set coincides with the unit circle, there exists a transcendental entire functionfwith an invariant Fatou component such thatgis associated withfin the above sense. Furthermore, there exists a single transcendental entire functionfwith the property that any finite Blaschke product can be arbitrarily closely approximated by an inner function associated with the restriction offto a wandering domain.
Evaluation of the Sexual Functioning of Individuals Living in Turkey During the COVID-19 Pandemic: An Internet-Based Nationwide Survey Study
Authors: Karsiyakali Nejdet , Sahin Yusuf , Ates Huseyin Aytac , Okucu Emrah , Karabay Emre 
Published: October 2020

Abstract

Introduction
Although many countries in the world prioritize self-isolation measures during the corona virus disease 2019 (COVID-19) pandemic period, the effects of this process on sexual functioning are not yet known.

Aim
To evaluate the effects of the COVID-19 pandemic on the sexual functioning of individuals who declared no medical history of the COVID-19 disease.

Methods
A total of 1,356 participants filled out an Internet-based survey between June 1 and June 20, 2020. The data from these participants were analyzed to determine sexual functioning in terms of sexual intercourse frequency and sexual desire during the COVID-19 pandemic. Subgroups analyses were also performed, wherein the subgroups were developed according to the population density of the cities in which the participants lived to examine whether population density has any effect on the sexual functions of the participants during the COVID-19 pandemic.

Main Outcome Measure
The study outcomes were obtained using a study-specific questionnaire to assess the changes in people's sexual functioning.

Results
The mean age of the participants was 33.16 ± 8.31 years. There was a statistically significant difference between the participants according to the decrease in the number of weekly sexual intercourses when they were compared in terms of smoking status, alcohol consumption, marital and parental status, being a health-care worker, having a regular sexual partner, and the working status during the COVID-19 pandemic (P &lt; .05, for each). In the subgroup analyses, it was observed that there was a statistically significant difference between the groups for change in the number of sexual intercourses, the number of masturbations, and sexual desire during the COVID-19 pandemic (P &lt; .05, for each).

Conclusion
A decline in sexual functioning was observed during the COVID-19 pandemic period. Living in a metropolitan area was associated with a decline in both sexual intercourse frequency and sexual desire during the COVID-19 pandemic.
Tener persona: Sur l’identité et l’identification dans les sociétés d’Ancien Régime
Authors: Buono Alessandro 
Published: October 2020

Tener persona: Sur l’identité et l’identification dans les sociétés d’Ancien RégimeCet article vise à éclaircir les logiques qui présidaient aux opérations d’identification et de revendication de l’identité personnelle dans la Monarchie espagnole d’Ancien Régime, en les contextualisant au sein de la culture juridique de leur époque. J’analyserai les sources produites par les Juzgados de bienes de difuntos (« Tribunaux des biens des défunts »), chargés d’adjuger les héritages d’attribution incertaine, en vérifiant l’identité et la parenté des personnes impliquées dans des successions à échelle mondiale. Au lieu d’interpréter la « preuve d’identité » de manière évolutionniste, je chercherai à comprendre sa production en partant de la constatation que, durant l’Ancien Régime, la personnalité juridique se concevait comme une possession, revendiquée activement par son usage, publiquement exercé et reconnu. Il s’agira donc de montrer que l’identité était détenue, comme tout autre droit, à travers des « actes de possession », et non simplement grâce à des titres de propriété, considérés plutôt comme une façon de transcrire les actes de possession d’état. L’article avance donc que, dans les sociétés d’Ancien Régime, il fallait continuellement produire la preuve de sa propre identité, en raison non seulement de l’insuffisance des procédures bureaucratiques et des pratiques d’archivage des données, mais, surtout, d’une manière différente de posséder la « chose identité », c’est-à-dire d’une autre façon de « tenir personne ».
Alliés, voisins et ennemis du roi d’Espagne: La puissante faiblesse de la Monarchie hispanique (1580-1620)
Authors: Ibáñez José Javier Ruiz , Sabatini Gaetano 
Published: October 2020

Alliés, voisins et ennemis du roi d’Espagne: La puissante faiblesse de la Monarchie hispanique (1580-1620)À la fin du xvie siècle, le roi d’Espagne et sa monarchie occupent aux yeux de l’Europe une position de prééminence. Non seulement de petits États, mais de nombreux mouvements insurrectionnels réclament son aide militaire et financière pour combattre leurs ennemis locaux et éviter d’être absorbés par leurs voisins. La Monarchie hispanique accroît alors sa capacité d’intervention en dehors de ses frontières, avec la possibilité d’incorporer de nouveaux territoires, tant en Europe qu’en Asie ou en Afrique ; à tout le moins, le pouvoir ibérique s’invite dans la politique intérieure de ces États, devenant un acteur supplémentaire de la scène politique locale. Cette sensation d’hégémonie est telle qu’elle nourrit en retour un puissant rejet : à de nombreux points du globe, jouer sur ce sentiment anti-espagnol devient un élément clef pour délégitimer des rivaux politiques et étayer les prétentions des vainqueurs dans les conflits civils de la fin du xvie siècle et du début du xviie siècle. Il faut dire que, dans une certaine mesure, l’hégémonie espagnole relevait d’un mirage : elle ne correspondait pas aux forces réelles du roi d’Espagne, mais plutôt à une image surévaluée du pouvoir de celui-ci, véhiculée par ceux qui placèrent en lui leurs espoirs ou leurs craintes. Analyser cette discordance entre représentation et réalité nous permet de comprendre, d’une part, comment la prédominance politique se fonde, pour partie, sur un imaginaire et des intérêts partagés, et, d’autre part, que son succès et son échec dépendent largement des illusions, des frustrations et des attentes divergentes qu’elle suscitait.
Emerging Standards and the Hybrid Model for Organizing Scientific Events During and After the COVID-19 Pandemic
Authors: Hanaei Sara , Takian Amirhossein , Majdzadeh Reza , Maboloc Christopher Ryan , Grossmann Igor , Gomes Orlando , Milosevic Milos , Gupta Manoj , Shamshirsaz Alireza A. , Harbi Amine , Burhan Amer M. , Uddin Lucina Q. , Kulasinghe Arutha , Lam Chi-Ming , Ramakrishna Seeram , Alavi Abass , Nouwen Jan L , Dorigo Tommaso , Schreiber Michael , Abraham Ajith , Shelkovaya Natalya , Krysztofiak Wojtek , Ebrahimi Warkiani Majid , Sellke Frank , Ogino Shuji , Barba Francisco J. , Brand Serge , Vasconcelos Clara , Salunke Deepak B. , Rezaei Nima 
Published: October 2020

AbstractSince the beginning of 2020, the coronavirus disease (COVID-19) pandemic has dramatically influenced almost every aspect of human life. Activities requiring human gatherings have either been postponed, canceled, or held completely virtually. To supplement lack of in-person contact, people have increasingly turned to virtual settings online, advantages of which include increased inclusivity and accessibility and a reduced carbon footprint. However, emerging online technologies cannot fully replace in-person scientific events. In-person meetings are not susceptible to poor Internet connectivity problems, and they provide novel opportunities for socialization, creating new collaborations and sharing ideas. To continue such activities, a hybrid model for scientific events could be a solution offering both in-person and virtual components. While participants can freely choose the mode of their participation, virtual meetings would most benefit those who cannot attend in-person due to the limitations. In-person portions of meetings should be organized with full consideration of prevention and safety strategies, including risk assessment and mitigation, venue and environmental sanitation, participant protection and disease prevention, and promoting the hybrid model. This new way of interaction between scholars can be considered as a part of a resilience system, which was neglected previously and should become a part of routine practice in the scientific community.