bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Corrective Contribution of Strong Halo-femoral Traction in the Treatment of Severe Rigid Nonidiopathic Scoliosis
Authors: Zhang Hongqi , Yang Guanteng , Guo Chaofeng , Liu Jinyang , tang minxing 
Published: June 2020

Abstract
Introduction: Strong halo-femoral traction has been widely used in the field of severe rigid scoliosis correction. The objective of this study was to analyze the corrective contribution of strong halo-femoral traction in the treatment of severe rigid nonidiopathic scoliosis and discuss its meaning.Material and methods: A retrospective review was performed for patients with severe rigid nonidiopathic scoliosis who were treated with halo-femoral traction in our center from December 2008 to December 2015. All cases underwent halo-femoral traction for 2 to 4 weeks before a one-stage posterior operation, and the absolute and relative contribution rates of each orthopedic factor (bending, fulcrum, traction, surgery) were analyzed.Results: A total of 38 patients were included (15 male and 23 female), with a mean age of 16.4± 3.73 years (10-22 years) and follow-up of 55.05 ± 6.63 mos. (range 40-68 mos.). The etiology was congenital in 17 patients, neuromuscular in 14 patients, neurofibromatosis-1 in 3 patients and Marfan syndrome in 2 patients. Congenital high scapular disease with scoliosis was found in 2 patients. The mean coronal Cobb angle of the major curve was 97.99°±11.47° (range 78°–124°), with a mean flexibility of 15.68% ±6.65%. The absolute contribution rate (ACR) of bending was 27.26% ±10.16%, the ACR of the fulcrum was 10.91% ±2.50%, the ACR of traction was 32.32% ±11.41%, and the ACR of surgery was 29.50% ±9.70%. A significant difference in correction was noted between the ACRs of traction and the fulcrum (P < 0.05).Discussion: Strong halo-femoral traction plays a relatively significant role in the treatment of severe rigid nonidiopathic scoliosis while decreasing the risk of operation, and it is a safe and effective method for the treatment of severe rigid nonidiopathic scoliosis.
The Value of 18F-PSMA-1007 PET/CT in Identifying High-Risk Prostate Cancer
Authors: Hong Jun-jie , Liu Bo-le , Wang Zhi-qiang , Tang Kun , Ji Xiao-wei , Yin Wei-wei , Lin Jie , Zheng Xiang-wu 
Published: June 2020

Abstract
Background: Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron-emission-tomography (PET)/ computer-tomography (CT) is an attractive modality to assess biochemical recurrence of PCa, detect metastatic disease and stage of primary PCa, making it a promising strategy for risk stratification. However, due to some limitation of 68Ga-PSMA-11 the development of alternative tracers is of high interest. In this study, we aimed to investigate the value of the new PET trace 18F-PSMA-1007 in identifying high-risk PCa.Methods: 170 patients with primary PCa underwent 18F-PSMA-1007 PET/CT were retrospectively analyzed. According to the European Association of Urology (EAU) guidelines on prostate cancer for PCa, patients were classified into low-intermediate-risk (LMR) group or high-risk (HR) group. The maximum standardized uptake values (SUVmax) of the primary prostate tumor was measured on PET/CT images. The diagnostic performance of PET/CT for LMR and HR PCa were calculated and the relationship between the SUVmax of primary prostate tumor, prostate-specific antigen (PSA) level and Gleason score (GS) were analyzed.Results: Of all 170 patients, 55 patients were classified into LMR group and 115 patients were classified into HR group. There was a significant positive correlation between the PSA level/GS and SUVmax (r = 0.597, r = 0.446, P < 0.001, respectively). Tumors with GS of 6 and 7a showed significantly lower 18F-PSMA-1007 uptake compared to patients with GS of 8, 9, and 10 (P < 0.001). SUVmax in patients of HR was significantly higher than those of LMR (median SUVmax: 20.20 versus 8.40; P < 0.001). In receiver operating characteristic (ROC) curve analysis, the optimal cutoff value of the SUVmax for identifying high-risk PCa was set as 10.78 (area under the curve [AUC]: 0.873; sensitivity: 90.4%; specificity: 69.1%). Conclusion: 18F-PSMA-1007 PET/CT showed the powerful diagnosis efficacy for high-risk PCa, which can be used as an objective imaging reference index for clinical reference.
High Occupational Physical Activity and cardiovascular risk factors in employees of Fomento de Construcciones y Contratas S.A. Company: a cross-sectional study
Authors: Gómez-Recasens Montse , Alfaro-Barrio Silvana , Tarro Lucia , Llauradó Elisabet , Solà Rosa 
Published: June 2020

Abstract
BackgroundThe impact of occupational physical activity (OPA) intensity, considering adults work many hours a day, on health is unknown. The present study aims to evaluate the association between the high intensity of OPA and cardiovascular risk factors of employees.MethodsA cross-sectional study was carried out in the “Fomento de Construcciones y Contratas S.A. Company” (FCC S.A. Delegation) in 2017, Spain. The intensity of OPA of each employee was classified by work categories in low (≤ 3 METs) or high (> 3 METs). Health and lifestyle data of employees were collected on medical consultation in the workplace.ResultsAssociations were analyzed between the high intensity of OPA and cardiovascular risk factors of employees. 751 employees, 55.5% (n = 417) with high intensity of OPA. An 82.2% (n = 245) of employees with low intensity of OPA presented overweight/obesity compared with 69.0% (n = 171) with high intensity of OPA employees (p < 0.001). In men, high intensity of OPA is negatively associated with Body Mass Index (BMI) (B: -0.042, p = 0.003), waist circumference (B: -0.027, p < 0.001) waist-hip ratio (B: -5.484, p < 0.001), cholesterol (B: -0.007, p = 0.001) and triglycerides (B= -0.003, p = 0.025). In women, high intensity of OPA was positively associated with blood pressure (BP) (systolic BP: B = 0.036, p = 0.005 and diastolic BP: B = 0.040, p = 0.021).ConclusionsIn conclusion, the high intensity of OPA is associated with less cardiovascular risk factors in men, whereas women are associated with high levels of blood pressure, suggesting an influence of gender and work categories.
Safety and efficacy of fentanyl combined with midazolam in bronchoscopy under bispectral index-guided conscious sedation
Authors: he qian , zhang sujuan , zhou jun , xu xiong , xu qianqian , qiu hui , guan suhong , han ying , dai pei , zhang qiudi 
Published: June 2020

Abstract
Background: Sedation combined with local anesthesia during bronchoscopy is widely accepted in America and Europe, and receiving great attention in China. This study aimed to investigate the safety and efficacy of fentanyl combined with midazolam for bispectral index (BIS) titrated conscious sedation during bronchoscopy in the Chinese population. Methods: Data from 436 patients who underwent bronchoscopy under local anesthesia (LA group) or BIS-guided conscious sedation combined with local anesthesia (FM group) were retrospectively analyzed. The analysis included vital signs, adverse events recorded during the procedure, and questionnaire information, such as patient tolerance and satisfaction, operator satisfaction, and the cough score noted after the procedure. Results: A total of 225 patients in the LA group, and 211 in the FM group were enrolled in the study. The blood pressure and oxygen saturation were significantly higher in the LA group than in the FM group during bronchoscopy (P<0.001). The heart rate was significantly faster in the LA group at T3max, T3min and T4 than in the FM group. The incidence of hypoxia and bradycardia was higher in the FM group than in the LA group, whereas incidence of hypertension and tachycardia was lower. Patient satisfaction and tolerance of the procedure were significantly better in the FM group. visual analog scale (VAS) scores for cough and operator satisfaction were better in the FM group than in the LA group. Sub-group analysis (inspection, biopsy and transbronchial biopsy guided by radial endobronchial ultrasound (rEBUS-TBB)) indicated that the vital signs, adverse event(hypoxia) and patient satisfaction of the two groups were similar to the previous results. However, the VAS scores for operators’ satisfaction was no significant difference between the two groups in patients undergoing inspection. Conclusions: The conscious sedation regimen of fentanyl combined with midazolam monitored by BIS during bronchoscopy is safe and effective. Although the incidence of hypoxia and bradycardia was higher, the patient’s tolerance and physician’s satisfaction were significantly improved, especially during lengthy procedures, such as intrabronchial biopsy and transbronchial biopsy guided by radial endobronchial ultrasound. Trial registration: The study was approved by the ethics committee of Changzhou first people's Hospital (2019-020).
The Clinical Significance and Potential Molecular Mechanisms of Synaptojanin 2 in Lung Adenocarcinoma
Authors: Lu Hui-Ping , Chen Shang-Wei , He Rong-Quan , Huang Zhi-Guang , Kong Jin-Liang , Zeng Jiang-Hui , Yang Jie , Yang Da-Ping , Mo Jun-Xian , Tang Zhong-Qing , Li Chang-Bo , Ma Fu-Chao , Zhou HuaFu , Chen Gang 
Published: June 2020

Abstract
Background

Lung adenocarcinoma (LUAD) is the main pathological type of pulmonary malignant tumors. Synaptojanin 2 (SYNJ2), a member of the synaptojanin family, is considered as an attractive underlying therapeutic target in several types of cancer. The purpose of the current research was to comprehensively investigate the molecular function and underlying mechanism of SYNJ2 in LUAD with the goal of providing a promising therapeutic target for LUAD.

Methods

We applied tissue microarrays, immunohistochemistry (IHC), high-throughput RNA sequencing (RNA-seq) data, and gene microarrays of public databases to comprehensively examine the protein level, mRNA expression, clinical significance, and prognosis value of SYNJ2 in LUAD. The standard mean difference (SMD) and summary receiver operating characteristic curves (SROC) were computed to evaluate the comprehensive expression value of SYNJ2 in LUAD. Kaplan-Meier survival curves were plotted to determine the overall survival of SYNJ2 with different expression levels in LUAD. Univariate and multivariate cox regression analyses were implemented to investigate the dependent prognostic ability of SYNJ2 expression and the clinically-relevant traits of LUAD. Moreover, SYNJ2 co-expressed genes were screened for Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) function analysis and protein–protein interactions (PPI) network construction.

Results

SYNJ2 overexpression in LUAD was confirmed by 2,299 LUAD samples and 1,387 non-tumor tissues obtained from tissue microarrays along with TCGA and public gene microarrays. The pooled SMD was 1.29 (95% CI: 1.09-1.48, I-square=78.6%, P<0.001) and the area under the curve (AUC) of the SROC was 0.88 (95%CI: 0.85-0.91). Compared to the upregulation of SYNJ2, SYNJ2 downregulation could improve OS in LUAD patients to some extent. SYNJ2 may facilitate the proliferation and progression of LUAD by modulating the cell cycle and TGF-beta signaling pathways. The 10 SYNJ2 co-expressed key genes selected from PPI network were all prominently implicated with the prognosis of LUAD patients.

Conclusion

SYNJ2 may contribute as an attractive and prospective therapeutic target in LUAD.
Hypoxia induced metastasis of gastric cancer through HIF1α/ANXA1/MMP-2 pathway
Authors: Liu Qing-Hua , Xia Lei , Lu Chen Chen , Liu Ying 
Published: June 2020

Abstract
BackgroundThe aim of this study was to investigate the mechanism of hypoxia induced metastasis of gastric cancer (GC). MethodThis study explored the clinical significance of hypoxia inducible factor (HIF) 1α and annexin A1 (ANXA1) in human GC by immunohistochemistry of a tissue microarray with 76 surgically resected GC specimens and further examined the mechanism of the role of HIF1α in GC.ResultsOur data demonstrated that HIF1α expression was dramatically increased in GC tissues. High HIF1α expressions were significantly correlated with lymph node metastasis and with worse survival in GC patients. In addition, HIF1α expression was an independent prognostic factor in GC patients and the combination of HIF1α and ANXA1 might serve as useful prognostic markers in GC patients. Furthermore, HIF-1α could promote GC migration and invasion through HIF1α/ANXA1/MMP-2 (Matrix metal proteinase 2) pathway.ConclusionsOur findings indicated that HIF-1α may serve as a promising prognostic biomarker and therapeutic target for inhibiting GC metastasis.
Oil Price Shocks and Sectoral Stocks Behaviour in Nigeria: How Relevant is Asymmetry and Structural Breaks?
Authors: Fasanya Ismail , Adekoya Oluwasegun B. , Odudu Temitope F. 
Published: June 2020

Abstract
In this paper, we model the relationship between oil price and stock returns for selected sectors in Nigeria using monthly data from January 2007 to December 2016. We employ both the Linear (Symmetric) ARDL by Pesaran et al. (2001) and Nonlinear (Asymmetric) ARDL by Shin et al. (2014) and we also account for structural breaks using the Bai and Perron (2003) test that allows for multiple structural changes in regression models. Our results indicate that the strength of this relationship varies across sectors, albeit asymmetric and breaks. We identify two structural breaks that occur in 2008 and 2010/2011 which coincidentally correspond to the global financial crisis and the Arab spring (Libyan shut-downs), respectively.Moreover, we observe strong supportfor asymmetry and structural breaks for some sectorsin the reaction of sector returns to movement in oil prices.These findings are robust and insensitive when considering different oil proxy.While further extensions can be pursued, the consideration of asymmetric effects as well as structural breaks should not be jettisoned when modelling this nexus.JEL codes: C22; C51; G12; Q43
Incivility towards nurses: A Systematic Review and Meta-analysis
Authors: Atashzadeh-Shoorideh Foroozan , Moosavi Soolmaz , Balouchi Abbas , Riley Georgina 
Published: June 2020

Abstract
Background
Creation and maintenance of a safe healthy work environment is one part of a nurse’s role. Evidence shows there is a presence of negative behaviors like incivility and violence in the nursing profession. This systematic review and meta-analysis determined the rate of incivility towards nurses and the factors affecting it.
Methods
All observational studies that primarily investigated the rate of incivility towards nurses were selected regardless of sampling method. The electronic databases “PubMed, Embase, Web of Sciences, Magiran, IranDoc, and Scopus” were searched for studies published during the period of January 1, 1996 to December 31, 2019. The quality of the selected studies was assessed with Hoy’s Critical Assessment Checklist. The study was undertaken using the random effects model. Data were analyzed with STATA14.
Results
Data on 61 articles, including data on 30801 individuals that were published during 1997–2019, entered the study. Prevalence of incivility was 50.10% (95%, CI: 48.05, 62.06).
Conclusion
Given the highly important role of nurses in care-giving, they deserve to have a safe working environment similar to other work milieus.
WITHDRAWN: Analysis of the effectiveness of wound closure techniques among surgeons and emergency physicians in Mecca Hospitals: Retrospective Cohort Study
Authors: Felemban Jeehad Mansour , Binyaseen Kenan A , Almalki Waleed S , Altowairqi Fahad S , Sakhakhini Amer O , Alharbi Ziyad 
Published: June 2020

Abstract
Objective: Wound suturing is a procedure performed at many medical specialties. This study aims to analyze the effectiveness of wound closure techniques by recognizing the common suturing techniques and materials that used in different type of wounds among surgeons and emergency physicians and to assess the rate of scars formation among their patients in-Mecca City Hospitals, Saudi Arabia.Results:Every participant selects and prefers some methods in wound closure over other methods. Choosing the simple interrupted technique exceeded 50% for all types of studied wounds. The other most common techniques among participants were subcuticular and vertical mattress respectively, also using stabler was limited to some wound types with less percentage than other suture techniques. Regarding suturing material, there are many materials alternatives were selected for the studied wounds such as 23% of participants used Monocryl for eyelid wounds, and 6% for breast wounds, also 9% of participants were using Polypropylene for scalp wounds and 8% for eyelids wounds. This study showed a high level of awareness among participants with a significant p-values regarding the important factors affecting wound healing and scare formation.
Monitoring the decomposition of wealth-related inequality in the use of regular antenatal care in Egypt (1995-2014)
Authors: Khadr Zeinab 
Published: June 2020

Abstract
Background Between 1995 and 2014 Egypt successfully increased the use of regular antenatal care (URAC) among women from 30.4% to 82.9%. The same period saw a decrease in the wealth-based inequality in URAC, with significant decline in its prevalence among the richest and poorest wealth quintiles. This paper investigates the changes in the main determinants contributing to the wealth-based inequality in URAC for the two years of 1995 and 2014, and the determinants that underlined the declines in this inequality. Methods The secondary analysis was based on data from the 1995 and 2014 rounds of the Egypt Demographic and Health Survey. Logistic regression was implemented to model URAC for those two years and inequality was measured using the concentration index. Decomposition of the concentration index and Blinder -Oaxaca decomposition were implemented to assess the contribution of the URAC determinants to its inequality and the changes between 1995 and 2014. Results Decomposition of inequalities in URAC in 1995 and 2014 showed that social determinants were the main contributors to these inequalities. More than 90% of the inequalities were explained by the determinants of living in rural Upper Egypt, women and their husbands having attained higher education, the household standard of living, and birth order. These same determinants were also responsible for more than 76% of the decline in the inequality in URAC between 1995 and 2014. Findings show that high concentration of poverty in rural Upper Egypt contributes significantly to the inequality in URAC. There was a relatively smaller change in the relationship between education and URAC, whereby women and their husbands who have secondary or higher education maintain their higher odds of URAC. These findings highlight the importance of the health system and the social determinants to achieve equality in URAC. Conclusion Decomposition of inequality can support prioritization of interventions and can lead to effective and efficient use of the limited resources available in any society. Decomposition of the changes in inequality can aid the assessment of the effectiveness and the monitoring of the impact of these interventions and help identify new policies and interventions needed to tackle these inequalities.
A Covariance Matrix-based Spectrum Sensing Technology Exploiting Stochastic Resonance and Filters
Authors: Lu Jin , Huang Ming , Yang Jingjing 
Published: June 2020

Abstract
Cognitive radio (CR) is a dynamic spectrum sharing technology designed to reduce the negative effect of spectrum scarcity caused by the exponential increase in the number of wireless devices. CR requires that spectrum sensing should detect licenced signals quickly and accurately and enable coexistence between primary and secondary users without interference. However, spectrum sensing with a low signal-to-noise ratio (SNR) is still a challenge in CR systems. This paper proposes a novel covariance matrix-based spectrum sensing method by using stochastic resonance (SR) and filters. SR is implemented to enforce the detection signal of multiple antennas in low SNR conditions. The filters are equipped in the receiver to reduce the interference segment of noise frequency. Then, two test statistics computed by the likelihood ratio test (LRT) or the maximum eigenvalues detector (MED) are constructed by the sample covariance matrix of the processed signals. The simulation results exhibit the spectrum sensing performance of the proposed algorithms under various channel conditions, namely, additive white Gaussian noise (AWGN) and Rayleigh fading channels. The energy detector (ED) is also compared with LRT and MED. The simulation results demonstrate that SR and filter implementation can achieve a considerable improvement in spectrum sensing performance under a strong noise background.
Green synthesis and application of silver nano-biotics for enhancing the antimicrobial activity of glass-ionomer cement against dental biofilm and its effect on compressive strength
Authors: El-Rab sanaa M. F. gad , Enan Enas Tawfik , Ashour Amal A. , Basha Sakeenabi , Felemban Nayef H. 
Published: June 2020

Abstract
Background.
The development of dental caries is associated with various microorganisms and secondary caries formation is the main cause of their failure. The urge for restorative dental materials that have antimicrobial properties has stimulated the introduction of materials containing different antibacterial agents.
Objectives
Present study has been designed to synthesize silver nanoparticles (AgNPs) and incorporate AgNPs and amoxicillin into glass ionomer cement (GIC) to synergize its effect on oral microbes. The effect of the added antimicrobial agents on compressive strength of GIC was also evaluated.
Material and methods
Biosynthesis of AgNPs was done using Cupressus macrocarpa extract and AgNPs were charectatrized. A total of 120 disc-shaped specimens were prepared and classified into 4 main groups where Group A include conventional GIC, Groups B and C include GIC with AgNPs or Amoxicillin, respectively, while Group D included GIC with both AgNPs and Amoxicillin. Each group was tested for the antimicrobial activity. The distribution of biofilm was examined via scanning electron microscope. Compressive strength (CS) of the tested material was measured using a Material Test System (MTS).
Results
UV-Visible spectrum showed a peak of 429 nm.TEM, XRD pattern and FTIR analysis confirmed the formation of AgNPs with spherical to oblong polydispersed particles of diameter in the range of 13.5–25.8 nm. The maximum inhibitory zone was recorded for group D against both Streptococcus mutans (S. mutans) and Staphylococcus aureus (S. aureus) bacteria with a mean of 29 mm at first 24-hour period to 15 mm at three weeks and showed antimicrobial rate 92.2% and 92.56%, against both strains, respectively. Additionally, group D disintegrated the structure of S. aureus biofilm and even kill bacteria in the biofilms. Addition of AgNPs and Amoxicillin caused insignificant effect on compressive strength of GIC.
Conclusion
Cupressus macrocarpa extract biosynthesized AgNPs showed a synergistic effect in combination with amoxicillin and GIC dental restorative material against dental biofilm. The agents can be safely added without impairing mechanical properties of the set cement.