bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSXIII-9 Can we predict feed efficiency using fecal microbiota information?
Authors: Sciellour Mathilde Le , Dejean Sébastien , Renaudeau David , Zemb Olivier 
Published: December 2019

Abstract
The present study aimed at predicting feed efficiency (FE) based on fecal microbiota, using partial least square regression (PLSR), sparse PLSR, and random forest regression (RF). Fecal samples from 147 Pietrain x (Large White x Landrace) pigs reared in two consecutive batches were collected at 99 days of age. Daily live body weight and feed intake were individually measured in pigs fed ad libitum with a corn soybean diet. The relative abundances of operational taxonomic units (OTU) resulting from fecal 16S rRNA sequencing were used to build the prediction models of FE between 99 and 113 days. From these data, neither PLSR nor RF models have been validated on external datasets. An important over-fitting has been observed in PLSR. With this aim to test the ability of the methods to retrieve information, synthetic OTU were created to fit an artificial Pearson correlation with FE (r² = 0 to 0.9) and were added among the predictors in the dataset. Artificial OTU correlated above 0.37 with FE improved the prediction in sparse PLSR and RF, and reduced the over-fitting. The best predictions were achieved by sparse PLSR. The present study emphasized the ability of sparse PLSR and RF to build valid prediction models of a quantitative phenotype, based on fecal microbiota composition. Since no OTU was correlated above 0.30 with FE in the real dataset, the power of the prediction methods was not enough to extract useful information from the fecal microbiota. The functional redundancy of the microbiota could explain the lack of relevant information in the real dataset to predict pigs’ quantitative phenotype. These results suggest that the best strategy is to run sparse PLSR only if a correlation higher than 0.37 is observed. This study is part of the Feed-a-Gene Project funded from the European Union’s H2020 Program (grant 633531).
PSXIII-6 Fat deposition in castrated pigs for production of dry-cured ham: Evaluation of nutritional and genetic strategies
Authors: Aymerich Pau , Jiménez-Moreno Encarnación , Bonet Jordi , Carrión Domingo , Coma Jaume 
Published: December 2019

Abstract
Fat deposition is an important trait for the dry-cured ham industry. A minimum ham fat thickness (HFT) is required for adequate processing. The objective of this study was to evaluate two different strategies to meet this minimum requirement, a nutritional and a genetic one. The study involved productive performance of a total of 147,883 animals (barrows and gilts) from 164 farms. The experimental unit for carcass traits harvested was a truck with 200 pigs each. The nutritional strategy consisted in reducing the SID Lys:NE during one month before slaughter in combination with a feed additive to improve meat quality (2500 kcal NE and 8 g SID Lys/kg vs. 2550 kcal NE and 6.5 g SID Lys/kg). Both feeding programs were offered to crossbreds from a lean Duroc sire line with two different synthetic dam lines. The genetic strategy consisted of comparing two crossbred derived from two Duroc sire line (lean vs fat) all fed the same standard finisher diet (2500 kcal NE and 8 g SID Lys/kg). Experimental feeding program impaired FCR by 0.035 kg/kg (P &lt; 0.05), and increased HFT by 0.28 mm (P &lt; 0.01). The fat Duroc sire line impaired FCR by 0.162 kg/kg (P &lt; 0.05) and increased HFT by 0.77 mm (P &lt; 0.001) compared to the lean one. In addition, one of the dam lines showed a greater HFT (P &lt; 0.001) with no effect on FCR. In conclusion, HFT can be increased through nutritional and genetic strategies assuming a negative effect on FCR. The effects were greater by using a genetic strategy (fatter Duroc sire line) than by the nutritional one (decreased SID Lys:NE ratio in a lean Duroc sire line).
Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone
Authors: Walroth Todd A , Boyd Allison N , Hester Allison M , Schoenle Marilyn K , Hartman Brett C , Sood Rajiv 
Published: December 2019

Abstract
Methadone is an opioid commonly used for acute pain management in burn patients. One adverse effect of methadone is QTc interval prolongation, which may be associated with adverse cardiac outcomes. There is currently a paucity of data regarding risk of QTc prolongation in burn patients taking methadone and a lack of evidence-based recommendations for monitoring strategies in this population. The study objective was to determine the prevalence, risk factors, and cardiac outcomes related to methadone-associated QTc prolongation in adult burn patients. A total of 91 patients were included and were divided into groups according to maximum QTc. QTc prolongation was defined as greater than or equal to 470 ms (males) or 480 ms (females). There were no differences between groups regarding patient-specific risk factors, baseline QTc, or time to longest QTc. Patients in the prolonged QTc group had a higher rate of cardiac events (44% vs 9%; P &lt; .001), higher median (IQR) change from baseline to longest QTc (61 ms [18,88] vs 23 ms [13,38]; P &lt; .001), higher median (IQR) total daily dose of methadone (90 mg [53,98] vs 53 mg [30,75]; P = .004), and longer median (IQR) length of stay (53 [33,82] vs 35 [26,52] days; P = .008). QTc prolongation in burn patients was associated with increased methadone dose and resulted in a higher rate of cardiac events. This study was the first of its kind to look at risk factors and cardiac outcomes associated with methadone use in burn patients.
Abdominal Tuberculosis in Children: Challenges, Uncertainty, and Confusion
Authors: Sartoris Giulia , Seddon James A , Rabie Helena , Nel Etienne D , Schaaf H Simon 
Published: December 2019

AbstractThe diagnosis of abdominal tuberculosis (TB) is challenging, and the prevalence of abdominal TB in children is likely underestimated. It may present with nonspecific abdominal symptoms and signs, but children who present with pulmonary TB may have additional abdominal subclinical involvement. Diagnosis is specifically challenging because none of the available diagnostic tools provide adequate sensitivity and specificity.In this review, we summarize the best available evidence on abdominal TB in children, covering the epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment. We propose a diagnostic approach that could be followed for symptomatic children. We believe that a combination of investigations could be useful to both aid diagnosis and define the extent of the disease, and we propose that abdominal ultrasound should be used more frequently in children with possible TB and any abdominal symptoms. This neglected disease has received little attention to date, and further research is warranted.
Diplopia and Strabismus After Corneal Refractive Surgery
Authors: Mehta Aditya , Reed Donovan , Miller Kyle E 
Published: December 2019

AbstractIntroductionDiplopia and strabismus are known complications after corneal refractive surgery (CRS). Within the U.S. Armed Forces, refractive surgery is used to improve the operational readiness of the service member, and these complications could cause significant degradation to their capability. This study was performed in order to identify the incidence of strabismus and diplopia following CRS within the U.S. Military Health System.MethodsA retrospective review of all patients who underwent photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK) in the Department of Defense from January 2006 through September 2013 was designed and approved by the Naval Medical Center Portsmouth Institutional Review Board. The military health system data mart was queried for all patients who underwent one of these procedures and subsequently had an International Classification of Disease-9 code for any strabismus or diplopia through 2014 allowing at least 1 year of follow-up. We then calculated the incidence of both diplopia and strabismus for these procedures as the primary measure and the overall prevalence as a secondary measure.ResultsA total of 108,157 patients underwent PRK or LASIK during our study period with 41 of these patients subsequently having a diagnosis of diplopia or strabismus. After chart review, 16 of these patients were excluded resulting in 25 patients for inclusion in either the strabismus (23 patients, 0.02%) or diplopia (3 patients, 0.003%) cohorts with one patient having both. Of the 23 patients with postoperative strabismus, 4 were new cases giving an incidence of 0.004% and 2 new cases of diplopia for an incidence of 0.002%.ConclusionDiplopia and strabismus are rare complications after CRS in the U.S. military population. These procedures continue to increase the operational readiness of our service members with minimal risk of these potentially debilitating complications. Overall, this study provides support for the continued use of PRK and LASIK despite study limitations related to the use of large databases for retrospective review. Future prospective studies using delineated preoperative and postoperative examinations with sensorimotor testing included may be able to resolve the limitations of this study.
Constraining the masses of planets in protoplanetary discs from the presence or absence of vortices – comparison with ALMA observations
Authors: Hallam P D , Paardekooper S-J 
Published: December 2019

ABSTRACT
A massive planet in a protoplanetary disc will open a gap in the disc material. A steep gap edge can be hydrodynamically unstable, which results in the formation of vortices that can act as tracers for the presence of planets in observational results. However, in a viscous disc, the potential formation of these vortices is dependent on the time-scale over which the massive planet accretes mass and with a sufficiently long time-scale it is possible for no vortices to form. Hence, there is a connection between the presence of vortices and the growth time-scale of the planet and it may therefore be possible to exclude a planetary interpretation of observed structure from the absence of vortices. We have investigated the effect of the planet growth time-scale on vortex formation for a range of planet masses and viscosities and have found an approximate relation between the planet mass, viscosity and planet growth time-scale for which vortices are not formed within the disc. We then interpret these results in the light of recent observations. We have also found that planets do not need to be close to a Jupiter mass to form vortices in the disc if these discs have low viscosity, as these can be caused by planets as small as a few Neptune masses.
Jets in the soft state in Cyg X-3 caused by advection of the donor magnetic field and unification with low-mass X-ray binaries
Authors: Cao Xinwu , Zdziarski Andrzej A 
Published: December 2019

ABSTRACT
The high-mass accreting binary Cyg X-3 is distinctly different from low-mass X-ray binaries (LMXBs) in having powerful radio and γ-ray emitting jets in its soft spectral state. However, the transition from the hard state to the soft one is first associated with quenching of the hard-state radio emission, as in LMXBs. The powerful soft-state jets in Cyg X-3 form, on average, ∼50 d later. We interpret the initial jet quenching as due to the hard-state vertical magnetic field quickly diffusing away in the thin disc extending to the innermost stable circular orbit in the soft state, or, if that field is produced in situ, also cessation of its generation. The subsequent formation of the powerful jets occurs due to advection of the magnetic field from the donor. We find this happens only above certain threshold accretion rate associated with appearance of magnetically driven outflows. The ∼50 d lag is of the order of the viscous time-scale in the outer disc, while the field advection is much faster. This process does not happen in LMXBs due to the magnetic fluxes available from their donors being lower than that for the wind accretion from the Wolf–Rayet donor of Cyg X-3. In our model, the vertical magnetic field in the hard state, required to form the jets both in Cyg X-3 and LMXBs, is formed in situ rather than advected from the donor. Our results provide a unified scenario of the soft and hard states in both Cyg X-3 and LMXBs.
Relativistic ocean r-modes during type-I X-ray bursts
Authors: Chambers F R N , Watts A L 
Published: December 2019

ABSTRACT
Accreting neutron stars (NS) can exhibit high frequency modulations in their lightcurves during thermonuclear X-ray bursts, known as burst oscillations. These frequencies can be offset from the NS spin frequency by several Hz (where known independently) and can drift by 1–3 Hz. One plausible explanation is that a wave is present in the bursting ocean, the rotating frame frequency of which is the offset. The frequency of the wave should decrease (in the rotating frame) as the burst cools hence explaining the drift. A strong candidate is a buoyant r-mode. To date, models that calculated the frequency of this mode taking into account the radial structure neglected relativistic effects and predicted rotating frame frequencies of ∼4 Hz and frequency drifts of &gt;5 Hz; too large to be consistent with observations. We present a calculation that includes frame-dragging and gravitational redshift that reduces the rotating frame frequency by up to $30 \, {\rm per\, cent}$ and frequency drift by up to $20 \, {\rm per\, cent}$. Updating previous models for the ocean cooling in the aftermath of the burst to a model more representative of detailed calculations of thermonuclear X-ray bursts reduces the frequency of the mode still further. This model, combined with relativistic effects, can reduce the rotating frequency of the mode to ∼2 Hz and frequency drift to ∼2 Hz, which is closer to the observed values.
Use of Mixed Reality Visualization in Endoscopic Endonasal Skull Base Surgery
Authors: Zeiger Joshua , Costa Anthony , Bederson Joshua , Shrivastava Raj K , Iloreta Alfred M C 
Published: December 2019

Abstract

BACKGROUND
Neuronavigation systems assist with spatial orientation during endoscopic transnasal skull base surgery, but they require a correlation of 3-dimensional (3D) views with 2-dimensional (2D) radiology studies.

OBJECTIVE
To outline an initial experience with a novel technology platform that provides intraoperative navigation using 3D reconstructions of patient anatomy for endoscopic surgery.

METHODS
A retrospective study of endoscopic anterior skull base and complex paranasal procedures was performed. Data from preoperative computed tomography and magnetic resonance imaging scans were fused to create 3D digital models of patient anatomy. Using the technology developed by Surgical Theater (Mayfield Village, Ohio), these reconstructions were designed to highlight particular anatomic regions of interest. The models were studied to guide the surgical approach and anticipate critical structures.
The reconstructions were linked with the navigational technology created by Brainlab (Munich, Germany) during endoscopic surgery. A dynamic image of the reconstruction was displayed alongside a matching endoscopic camera view. These 2 views could be overlaid to provide an immersive, mixed reality image of the patient's anatomy.

RESULTS
A total of 134 cases were performed. The pathologies included tumors of the anterior skull base or sinonasal cavity, inflammatory sinus disease, and cerebrospinal fluid leaks. Specific anatomic structures, such as the internal carotid arteries and optic nerves, were chosen for enhancement. Surgeons felt that the technology helped to guide the extent of bony dissection and to identify critical structures.

CONCLUSION
We describe the first clinical series of complex skull base pathologies treated using a novel mixed reality platform.
A prospective study of Escherichia coli bloodstream infection among adolescents and adults in northern Tanzania
Authors: Madut Deng B , Rubach Matthew P , Kalengo Nathaniel , Carugati Manuela , Maze Michael J , Morrissey Anne B , Mmbaga Blandina T , Lwezaula Bingileki F , Kilonzo Kajiru G , Maro Venance P , Crump John A 
Published: December 2019

ABSTRACT

Background
Characterization of the epidemiology of Escherichia coli bloodstream infection (BSI) in sub-Saharan Africa is lacking. We studied patients with E. coli BSI in northern Tanzania to describe host risk factors for infection and to describe the antimicrobial susceptibility of isolates.

Methods
Within 24 h of admission, patients presenting with a fever at two hospitals in Moshi, Tanzania, were screened and enrolled. Cases were patients with at least one blood culture yielding E. coli and controls were those without E. coli isolated from any blood culture. Logistic regression was used to identify host risk factors for E. coli BSI.

Results
We analyzed data from 33 cases and 1615 controls enrolled from 2007 through 2018. The median (IQR) age of cases was 47 (34–57) y and 24 (72.7%) were female. E. coli BSI was associated with (adjusted OR [aOR], 95% CI) increasing years of age (1.03, 1.01 to 1.05), female gender (2.20, 1.01 to 4.80), abdominal tenderness (2.24, 1.06 to 4.72) and urinary tract infection as a discharge diagnosis (3.71, 1.61 to 8.52). Of 31 isolates with antimicrobial susceptibility results, the prevalence of resistance was ampicillin 29 (93.6%), ceftriaxone three (9.7%), ciprofloxacin five (16.1%), gentamicin seven (22.6%) and trimethoprim-sulfamethoxazole 31 (100.0%).

Conclusions
In Tanzania, host risk factors for E. coli BSI were similar to those reported in high-resource settings and resistance to key antimicrobials was common.
A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering
Authors: Ahmetaj‐Shala Blerina , Kawai Ryota , Marei Isra , Nikolakopoulou Zacharoula , Shih Chih‐Chin , Konain Bhatti , Reed Daniel M. , Mongey Róisín , Kirkby Nicholas S. , Mitchell Jane A. 
Published: December 2019

AbstractBlood vessels are comprised of endothelial and smooth muscle cells. Obtaining both types of cells from vessels of living donors is not possible without invasive surgery. To address this, we have devised a strategy whereby human endothelial and smooth muscle cells derived from blood progenitors from the same donor could be cultured with autologous leukocytes to generate a same donor “vessel in a dish” bioassay. Autologous sets of blood outgrowth endothelial cells (BOECs), smooth muscle cells (BO‐SMCs), and leukocytes were obtained from four donors. Cells were treated in monoculture and cumulative coculture conditions. The endothelial specific mediator endothelin‐1 along with interleukin (IL)‐6, IL‐8, tumor necrosis factor α, and interferon gamma‐induced protein 10 were measured under control culture conditions and after stimulation with cytokines. Cocultures remained viable throughout. The profile of individual mediators released from cells was consistent with what we know of endothelial and smooth muscle cells cultured from blood vessels. For the first time, we report a proof of concept study where autologous blood outgrowth “vascular” cells and leukocytes were studied alone and in coculture. This novel bioassay has usefulness in vascular biology research, patient phenotyping, drug testing, and tissue engineering.
Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Adult Males
Authors: Schneider Tobias , Luethi Julian , Mauermann Eckhard , Bandschapp Oliver , Ruppen Wilhelm 
Published: December 2019

Abstract

Background
Open label placebos with patient education are effective in reducing chronic pain, and recent studies on their effect on pain have established interest in this field. Nevertheless, data on their effect on acute pain are scarce, and on hyperalgesia and allodynia, absent. This study assessed the effect of open label placebos on acute pain in healthy adult males and the influence of placebo education.

Methods
Thirty-two healthy males were included in this prospective, randomized, assessor-blinded crossover, single-center study assessing pain intensities (via numeric rating scale), area of hyperalgesia (von Frey filament), and allodynia (dry cotton swab) in a pain model utilizing intracutaneous electrical stimulation. The authors compared the effect of intravenous open label placebo on pain compared to no treatment. The authors further examined the effect of placebo on hyperalgesia and allodynia, and the influence of education (short vs. detailed) before placebo application. Saliva cortisol concentrations were also measured.

Results
Pain ratings (median, first to third quartile) were 21% lower during placebo treatment compared to no treatment, 4.0 (3.2 to 4.9) versus 5.1 (4.7 to 5.4), respectively (P = 0.001). The areas of hyperalgesia and allodynia were lower during placebo treatment compared to no treatment (hyperalgesia, 30 cm2 [17 to 47] vs. 55 cm2 [42 to 68], P = 0.003; allodynia, 24 cm2 [11 to 39] vs. 45 cm2 [31 to 62], P = 0.007). This corresponds to reductions of 47%. The extent of placebo education had no effect on pain. Saliva cortisol decreased significantly over time and was under the limit of detectability in the majority of participants in postbaseline measurements in both treatment branches. Baseline cortisol was not associated with the placebo effect or strength applied of current to reach defined pain ratings.

Conclusions
Open label placebos might play a role in multimodal analgesic concepts.

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Weight-Based Estimation of Insertion Length of the Nasogastric Tube in Extremely Low Birth-Weight Infants
Authors: Kato Yuta , Hirata Katsuya , Oshima Yukari , Wada Kazuko 
Published: December 2019

Background:
Nasogastric (NG) tubes are used in the neonatal intensive care unit (NICU) for various indications. However, evidence of the best practice for estimating the NG tube insertion length in extremely low birth-weight (ELBW) infants is limited.

Purpose:
To determine a weight-based estimation formula of NG tube length in ELBW infants.

Methods:
This prospective study was performed at a single-center level III neonatal intensive care unit. Low birth-weight infants admitted between May 2009 and May 2010 who required radiography for clinical reasons were included. Radiographs of participants whose current body weights (BWs) were less than 2500 g were reviewed, and the appropriate ideal insertion length of the NG tube adjusted based on radiographs and the infant's current BW was assessed. A regression model was used to determine the ideal insertion length of the NG tube with respect to the current BW.

Results:
Overall, 533 radiographs (152 patients weighing 422-2486 g) were analyzed. Among the patients, 246 had BWs less than 1000 g and 287 had BWs more than 1000 g. Formulas that predicted NG tube length (centimeters) were derived as follows: (5 × weight [kg] + 10 [BW < 1.0 kg]) or (3 × weight [kg] + 12.5 [1.0 < BW <2.5 kg]).

Implications for Practice:
The application of the weight-based formula for estimating the NG tube length derived from the present study together with commonly used morphological methods may improve the accuracy of the NG tube insertion procedure in ELBW infants.

Implications for Research:
Further studies in other cohorts are needed.