bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special Subject of Crime as an Object of Criminological Determination
Authors: Makarov Andrey , Protasevich Aleksandr , Zhukova Aleksandra 
Published: March 2020

Currently, many authors pay attention to the criminological description of the object of their research. This approach is absolutely justified. It is better to examine the institutes of criminal law in correlation with the interdisciplinary spheres of knowledge. The article presents an analysis of adjacent but not equal legal categories of the subject of crime and the personality of a criminal. This research is relevant today because crimes committed by persons with characteristics of a special subject in general, and with the use of their official position in particular, have a higher degree of public danger. It is connected with a wide area of official interests of public officers. Their criminal offences destabilize the normal work of governmental bodies. Corruption, abuse of office, general crimes committed for personal gain act as negative social and legal phenomena that widen the range of persons in criminal statistics referring to special subject. A heightened degree of public danger in the actions of public officers is a factor that influences current criminal legislation. An example is the abuse of public office as a circumstance that aggravates criminal liability. The contents of the norms in the Special Part of the Criminal Code of the Russian Federation could be named a legislative reaction of the authorities to the growing level of misuse of office. The current Criminal Code of the Russian Federation mentions the misuse of office with mercenary motives or for personal gain, acting as an aggravating circumstance for the main crime, over 60 times. Taking into account that the contemporary condition and scale of the self-determination of crime according to the characteristic of a special subject are developing interconnected systemic causes and conditions, it is possible to discuss the necessity of criminological prevention of crimes with a special subject — a criminogenic person who has specific functions (as a rule, a representative of authorities).
Aproximación a una teoría de los derechos humanos del consumidor en el mercado global y su tratamiento en el derecho constitucional peruano
Authors: Durand Carrión Julio Baltazar 
Published: March 2020

Existe en la doctrina un debate con relación al carácter constitucional de los derechos del consumidor. Al respecto se han esgrimido una serie de argumentos que tratan de explicar su esencia, partiendo del derecho administrativo, del derecho civil, del derecho ordenador del mercado, de la teoría de los intereses difusos, entre otros. En este artículo se desplegará un desarrollo conceptual, sistémico y coherente con el fin de entender cuáles son los fundamentos iusfilosóficos que permitirían estudiar la naturaleza del derecho del consumidor, su esencia y el porqué de su tratamiento constitucional.
No se ha establecido, con la misma prolijidad con que se ha hecho para los derechos humanos de primera generación, un conjunto de garantías para los derechos sociales de manera suficiente, precisa y coherente, que les otorgue eficacia.
A Hybrid Approach for the Prediction of Relative Permeability Using Machine Learning of Experimental and Numerical Proxy SCAL Data
Authors: Zhao Bochao , Ratnakar Ram , Dindoruk Birol , Mohanty Kishore 
Published: March 2020

Summary
Accurate estimation of relative permeability is one of the key parameters for decision making in upstream applications from project appraisal to field development and evaluation of various field development options. In this study, we identify Euler number (Arns et al. 2001) (a quantitative measure of fluid connectivity/distribution) and saturation as being the first-order predictors of relative permeability and develop a reliable correlation between them using machine learning of experimental special core analysis (SCAL) data and pore network simulation results.
In order to achieve our objective, first, we developed a machine-learning model based on the random forest algorithm (Breiman 2001) to analyze specific SCAL data that indicates a key missing feature in the traditional saturation-based relative permeability prediction. We identified this missing feature and proposed the Euler characteristic as a potential first-order predictor of relative permeability in combination with in-situ fluid saturations. We generated “artificial” relative permeability data using pore network simulation (Valvatne and Blunt 2004) by systematically varying a set of key parameters such as pore geometry, wettability, and saturation history. Subsequently, we used machine learning to rank the importance of each parameter and identify possible correlative responses to those selected variables.
At a fixed saturation (zero-dimensional volumetric abundance) and Euler number coordinates, the relative permeability is very consistent and varies insignificantly across different cases, suggesting these two parameters as first-order predictors. Euler number characterizes the fluid connectivity/distribution, while saturation represents the net volumetric fluid quantity. We believe that Euler number could be the missing first-order predictor in traditional saturation-based predictive relative permeability models, especially for connected pathway dominated flow regime. Finally, we identified the quantitative relationship between relative permeability and Euler characteristic, and present a reliable correlation to determine the relative permeability on the basis of Euler number and saturation.
New Insights into Carbonate Matrix Acidizing Treatments: A Mathematical and Experimental Study
Authors: Ali Mahmoud T. , Nasr-El-Din Hisham A. 
Published: March 2020

Summary
The design process of carbonate matrix acidizing treatments requires coring and conducting linear, radial coreflood experiments. With the current environment revolving around cutting costs, it has become increasingly important to accurately design cost-effective acidizing treatments. This work aims to introduce a novel approach to predicting the performance of acid treatments in the field using log data only. A radial reactive flow simulator, using porosity distributed from logs, is used to provide accurate predictions without the need for experiments.
Coreflood acidizing experiments at 150 and 200°F with two acid concentrations were studied. A reactive flow simulator was built using porosity distribution derived from computed-tomography (CT) scans and tuned to match experimental data. A new radial simulation model of 3.25-ft radius was used to study acid propagation under field conditions. For accurate predictions, porosity was distributed using values derived from cores’ CT scans. Simulation results were compared with traditional 1D models. Different porosity distributions, including gamma distributions, were used in the radial model.
The reactive flow simulator was able to accurately capture wormhole propagation inside the linear core. A greater than 90% match between the experimental and the simulated acid pore volume (PV) to breakthrough (PVBT) was obtained using two acid concentrations’ different temperatures. The simulation results from the radial field-scale model show that the optimal velocity can be higher or lower than those predicted from laboratory experiments. Accordingly, caution must be taken when linear coreflood data are used to predict acid propagation in the field. The simulations showed that traditional upscaling models overpredict acid volumes; the predicted volumes are double at moderate to high injection rates. Models using statistically distributed porosity can provide accurate acid-propagation predictions, with a relative percentage error of less than 25% at extremely high injection rates.
This work introduces an accurate model using porosity directly from logs to predict acid performance while avoiding expensive designs. The simulation results reveal that traditional designs overpredict acid volumes required for field treatments. The statistically distributed porosity can be used as a substitute for CT-scan-derived porosity with a low effect on model predictability. The reactive flow simulator can accurately match experimental data.
Racial Disparities of Black Americans Hospitalized for Decompensated Liver Cirrhosis
Authors: Spiewak Ted , Taefi Amir , Patel Shruti , Li Chin-Shang , Chak Eric 
Published: March 2020

Abstract
Background & Aims: Racial disparities have been reported in liver transplantation and chronic hepatitis C treatment outcomes. Determining causes of these disparities is important given the racially diverse American population and the economic burden associated with chronic liver disease. Methods: A retrospective study was performed among 463 patients diagnosed with cirrhosis admitted from (January 1, 2013 to January 1, 2018) to a tertiary care academic medical center. Patients were identified based on the International Classification of Diseases (ICD-10) for cirrhosis or its complications. Demographic information, laboratory data, medical comorbidities, insurance and adherence to cirrhosis quality care indicators were recorded to determine their relationship to readmission rates and other healthcare outcomes. Results: A total of 463 individual patients with cirrhosis were identified including Whites (n=241), Hispanics (n=106), Blacks (n=50), Asian and Pacific Islander Americans (API, n=27) and Other (n=39). A significantly higher proportion of Blacks had Medicaid insurance compared to Whites (40% versus 20%, p=0.0002) and Blacks had lower median income than Whites ($45,710 versus $54,844, p=0.01). All groups received high quality cirrhosis care. Regarding healthcare outcomes, Black patients had the highest mean total hospital admissions (6.1±6.3, p=0.01) and the highest mean number of 30-day re-admissions (2.1±3.7, p=0.05) compared to all other racial groups. Multivariable proportional odds regression analysis showed that race was a statistically significant predictor of 90-day readmission (p=0.03). Conclusions: Black Americans hospitalized for complications of cirrhosis may experience significant disparities in healthcare outcomes compared to whites despite high quality cirrhosis care. Socioeconomic factors may contribute to these disparities.
Profiling of Koumiss Microbiota and Organic Acids and their Effects on Koumiss Taste
Authors: Tang Hai , Ma Huimin , Hou Qiangchuan , Li Weicheng , Xu Haiyan , Liu Wenjun , Sun Zhihong , Haobisi Halatu , Menghe Bilige 
Published: March 2020

Abstract
Background Koumiss is a naturally fermented mare’s milk. Over recent decades, numerous studies have revealed the diversity of lactic acid bacteria in koumiss. However, there is limited information available regarding its secondary major component yeast profile. Results A total of 119 bacterial and 36 yeast species were identified among the 14 koumiss samples. The dominant bacterial species in koumiss were Lactobacillus helveticus , Lactobacillus kefiranofaciens , Lactococcus lactis , Lactococcus raffinolactis , and Citrobacter freundii. The main yeast species were Dekkera anomala , Kazachstania unispora , Meyerozyma caribbica , Pichia sp.BZ159 , Kluyveromyces marxianus , and uncultured Guehomyces . The bacterial and yeast Shannon diversity of the Xilinhaote-urban group were higher than those of the Xilingol-rural group. The most dominant organic acids were lactic, acetic, tartaric, and malic acids. Lactic acid bacteria species were mostly responsible for the accumulation of those organic acids, although Kazachstania unispora , Dekkera anomala , and Meyerozyma caribbica may also have contributed. Redundancy analysis suggested that both bacteria and yeast respond to koumiss flavor, such as Lactobacillus helveticus and Dekkera anomala are associated with sourness, astringency, bitterness, and aftertaste, whereas Lactococcus lactis and Kazachstania unispora are associated with umami. Conclusions Our results suggest that differences were observed in koumiss microbiota of Xilinhaote-urban and Xilingol-rural samples. The biodiversity of the former was higher than the latter group. Positive or negative correlations between bacteria and yeast microbiota and taste also were found.
Agrobacterium tumefaciens mediated transformation of the aquatic carnivorous plant Utricularia gibba
Authors: Oropeza-Aburto Araceli , Cervantes-Perez Sergio Alan , Albert Victor A , Herrera-Estrella Luis Rafael 
Published: March 2020

Abstract
Background The genus Utricularia belongs to Lentibulariaceae, the largest family of carnivorous plants, which includes terrestrial, epiphytic and aquatic species. The development of specialized structures that evolved for carnivory is a feature of this genus that has been of great interest to biologists since Darwin‘s early studies. Utricularia gibba is itself an aquatic plant with sophisticated bladder traps having one of the most complex suction mechanisms for trapping prey. However, the molecular characterization of the mechanisms that regulate trap development and the biophysical processes involved in prey trapping are still largely unknown due to the lack of a simple and reproducible gene transfer system. Results Here, we report the establishment of a simple, fast and reproducible protocol for genetic transformation of U. gibba based on the T-DNA of Agrobacterium tumefaciens . An in vitro selection system using Phosphinotricin as a selective agent was established for U. gibba . Plant transformation was confirmed by histochemical GUS assays and PCR and qRT-PCR analyses. We report on the expression pattern of the 35S promoter and of the promoter of a trap-specific ribonuclease gene in transgenic U. gibba plants. Conclusions The genetic transformation protocol reported here is an effective method for studying developmental biology and functional genomics of this genus of carnivorous plants and advances the utility of U. gibba as a model system to study developmental processes involved in trap formation.
Health-Related Quality of Life Among Children With Transfusion-Dependent Thalassemia: A Cross-Sectional Study in Malaysia
Authors: Shafie Asrul Akmal , Chhabra Irwinder Kaur , Yi Jacqueline Wong Hui , Mohammed Noor Syahireen , Ibrahim Hishamshah Mohd , Alias Hamidah 
Published: March 2020

Abstract
Background: The treatment of children with transfusion-dependent thalassemia (TDT) in Malaysia has progressed since 2005. This study provides an updated health-related quality of life (HRQoL) assessment for children with the disorder and the factors affecting the HRQoL.Methods: A cross-sectional HRQoL survey of Malaysian children with TDT was conducted using the PedsQL™ 4.0 Generic Core Scales. Patients with non-transfusion dependent thalassemia and other haemoglobinopathies were excluded. Parent-proxy and self-reported HRQoL scores were obtained using a multi-stage convenient sampling. The relationship between HRQoL scores and demographic factors were tested using association, correlation and regression analysis. Results: A total of 368 patients were recruited. The mean (SD) Total Summary Score (TSS) was 80.12(13.87). Predictors for a lower TSS was an increasing age group and the use of dual chelating agents (R2 = 0.057, F (4, 359) = 5.40, p = <0.001). The mean (SD) Physical Health Summary Score (PHSS) was 82.21 (16.82). Predictors of a higher PHSS score was being male, while predictors of a lower score was an increasing age group and parent-proxy reports(R2 = 0.075, F (5,358) = 5.80, p = <0.001). The mean (SD) Psychosocial Health Summary Score (PCHS) was 79.39 (14.81). Predictors for a lower PCHS was the use of dual chelating agents(R2 = 0.041, F (1, 362) = 15.60, p = <0.001). The school functioning score had the lowest mean (SD) score of 69.52(20.92) in the psychosocial dimension.Conclusion: The HRQoL of TDT children in Malaysia has improved over the last decade owing to the better access in treatment. However, further effort is needed to improve the school functioning dimension.
Feasibility of Using an Led-Probe in Third-Space Endoscopy: A Clinical Study
Authors: Mondragón Oscar Victor Hernández , Mottu Raul Antonio Zamarripa , Pineda Omar Michell Solórzano , Aguilar Raul Antonio Gutierrez , Contreras Luis Fernando Garcia 
Published: March 2020

Abstract
Background and aims: Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting devices are used to prevent organic injuries. We aimed to investigate the feasibility of using a hand-made LED-probe (LP) in third-space procedures.Patients and Methods: This prospective study was conducted in a tertiary-care center in Mexico between December 2016 and January 2019. We included peroral endoscopic myotomy (POEM) and gastric peroral endoscopic myotomy(G-POEM) procedures. Pseudoachalasia, peptic ulcer, normal gastric emptying scintigraphy (GES) and prepyloric tumors were excluded. LP was used to guide or confirm procedures. Clinical and procedural characteristics were recorded and analyzed.Results: Seventy third-space procedures were included (42POEM,28G-POEM), with an average patient age of 46.7±14.3 and 43.7±10.1 years, respectively. For the POEM and G-POEM groups, respectively, 18/42(42.9%) and 13/28(46.7%) patients were males; median procedure times were 50 (interquartile range[IQR]: 38-71) and 60(IQR: 48-77) min, median LP placement times were 5(IQR: 4-6) and 6(IQR: 5-7) min, mild adverse events occurred in 4(9.4%) and 4(14.2%) of cases, and clinical success at 6 months occurred in 100% and 85.7% of cases. Integrated relaxation pressure (IRP) improved from 27.3±10.8 to 9.5±4.1 mmHg (p<0.001); retention percentage at 4 hours also improved. LP was successfully placed and adequate myotomy confirmed including 14.2% and 17.8% of POEM and G-POEM difficult patients. Conclusions: Using an LP is promising and allows guiding during third-space procedures either for submucosal tunnel creation or myotomy confirmation, with excellent safety and efficacy in clinical practice.
Pre-operative hemoglobin level and use of sedative-hypnotics are independent risk factors for post-operative delirium following total knee arthroplasty.
Authors: Kijima Eiji , Kayama Tomohiro Thomas , Saito Mitsuru , Kurosaka Daisaburo , Ikeda Ryo , Hayashi Hiroteru , Kubota Daisuke , Hyakutake Takashi , Marumo Keishi 
Published: March 2020

Abstract
Background: Delirium is a well-known complication following surgery, especially with the increasing age of patients undergoing surgery. The increasing demands resulting from a prolonged healthy life expectancy has resulted in more arthroplasties despite their age and existing comorbidities. The purpose of this study is to explore the various risk factors that may contribute to delirium in unilateral and bilateral total knee arthroplasties in the elderly population. Methods: 170 patients who underwent unilateral or bilateral total knee arthroplasties were analyzed retrospectively for delirium. Age, sex, comorbidities, use of sedative-hypnotics, peri-operative blood loss, pre- and post-operative laboratory blood test results were investigated and analyzed. Results: The incidence of post-operative delirium was 6.5% (11 out of 170 patients) with a mean age of 79.5 (± 6.9) years, compared to 73.0 (± 9.0) years in the non-delirium group. Higher age, use of sedative-hypnotics, low pre-operative Hb and Ht, low post-operative Hb, Ht and BUN were observed in the delirium group. Multivariate logistic regression analysis identified that the use of sedative-hypnotics and pre-operative Hb level were independent risk factors for post-operative delirium after TKA. The odds ratios for the use of sedative-hypnotics and pre-operative Hb level were 4.6 and 0.53, respectively. Receiver operating characteristic curve analysis showed that pre-operative Hb of less than 11.1 g/dL was a predictor for the development of delirium, with a sensitivity of 54.6% and a specificity of 91.6%.Conclusion: Patients with a pre-operative Hb level of <11.1 g/dL or those using sedative-hypnotics are associated with post-operative delirium. Peri-operative management and preventative measures are therefore needed to reduce the risks of post-operative delirium in such patients.
Clinical and microbiological characteristics of Cryptococcus gattii isolated from 7 hospitals in China
Authors: Jin Liang , Cao Jingrong , Xue Xinying , Wu Hua , Wang Lifeng , Guo Ling , Shen Dingxia 
Published: March 2020

Abstract
Background: Infection, even outbreak, caused by Cryptococcus gattii (C. gattii ) has been reported in Canada and the United States, but there were sparsely-reported cases of C. gattii in China. Our interest in occurrence, clinical manifestation, laboratory identification and molecular characterization of Chinese C. gattii strains leads us to this research.Methods: A total of 254 clinical isolates primarily identified as Cryptococcus neoformans (C. neoformans ) were collected. VITEK 2 compact, canavanine glycine bromothymol blue (CGB) agar and Bruker Biotyper matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) were used for strain identification. Multi-locus sequence typing (MLST) was performed for genotyping. Antifungal susceptibility test was carried out with commercial kits of both ATB fungus 3 and Yeast one. Clinical information of patients was reviewed retrospectively. Label-free proteome technique was used to quantitatively analyze the differential proteins of C. gattii. Results: Out of 254 clinical isolates, we identified eight strains as C. gattii. MLST showed genotype VGI accounted for the most (6 / 8), the other two strains were genotype VGII（VGIIa and VGIIb respectively）with 3 specific spectra of molecular weight about 4342, 8686, 9611 Dalton by MALDI-TOF MS. The minimal inhibitory concentrations (MICs) of Fluconazole with Yeast one was 2～4 times higher than that with ATB fungus 3. Higher MICs of antifungal agents were exhibited against VGII strains than against VGI strains. C. gattii genotype VGI and VGII possessed 418 and 774 specific proteins respectively. Comparative proteome analysis showed that 329 and 180 proteins were highly expressed in C. gattii VGI and VGII. The enrichment of differentially expressed proteins was directed to Golgi complex.Conclusions: Infection by C. gattii in China might have been underestimated because of initial mis-identification. Genotype VGI was predominant but VGII was more resistant to antifungal agents. There was significant difference in protein expression profile between VGI and VGII C. gattii.