bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI AKTIVITAS FOTOKATALIS TIO2 DOPAN-N KOMBINASI ZEOLIT PADA PENGOLAHAN LIMBAH FARMASI
Authors: Wildan Achmad , Mutiara Erlita Verdia 
Published: November 2019

Titanium dioksida (TiO2) adalah senyawa yang sering digunakan pada proses fotokatalisis, untuk lebih meningkatkan aktivitas fotokatalis TiO2 dapat dilakukan dengan penambahan dopan Nitrogen dari urea, selain itu digunakan pula kombinasi TiO2 dengan suatu adsorben seperti zeolit yang ditambahkan diharapkan dapat mencegah terjadinya rekombinasi electron-hole sehingga aktivitas fotokatalisis dalam mendegradasi senyawa organik dan mereduksi senyawa anorganik lebih efektif dan optimal. Tujuan penelitian ini adalah untuk mengetahui pengaruh keberadaan senyawa zeolit, serta lama penyinaran terhadap efektivitas proses fotodegradasi siprofloksasin yang terkatalisis TiO2 Dopan-N zeolit dengan adanya ion Cu(II). Penelitian menggunakan reaktor tertutup, pengaduk magnetik dan lampu tungsten sebagai sumber sinar tampak. Penelitian tersebut menunjukkan hasil terjadinya peningkatan siprofloksasin yang terdegradasi dengan waktu penyinaran yang semakin lama. Peningkatan ini disebabkan karena terjadinya peningkatan jumlah radikal •OH yang dihasilkan TiO2.Variasi penambahan senyawa zeolit menunjukkan semakin besar perbandingan komposisi TiO2-N : Zeolit, fotodegradasi siprofloksasin mengalami kenaikan. Kondisi optimal pada proses fotokatalisis yang menghasilkan fotodegradasi siprofloksasin paling efektif yaitu, larutan 50 mg/L sebanyak 25 ml, dengan waktu penyinaran 100 menit dan perbandingan TiO2-Ndan Zeolit adalah 35 : 1. Pada kondisi tersebut jumlah siprofloksasin yang mengalami fotodegradasi sebesar 85,49% dan jumlah ion Cu(II) yang mengalami proses reduksi sebesar 92,79%. Kata kunci: : Fotokatalis TiO2, Ion Tembaga, Siprofloksasin, Spektrofotometer
Pododermal angioarchitecture in the equine hoof wall: A light and scanning electron microscopic study of the wall proper
Authors: Sievers H. , Hiebl B. , Hünigen H. , Hirschberg R.M. 
Published: November 2019

BACKGROUND: Blood supply is an important factor for the normal function of the equine hoof, but earlier studies present conflicting data on functional characteristics of its angioarchitecture. OBJECTIVE: Emphasis was laid on demonstration of the microvascularisation in the different hoof wall regions, aiming at assessment of specialised vascular structures, e.g. vascular sphincter mechanisms and arteriovenous anastomoses. METHODS: The angioarchitecture of the adult pododerma in the equine hoof wall was examined by scanning electron microscopy of micro-corrosion casts assisted by exemplary histological and immuno-histochemical characterisation of the pododermal vasculature. RESULTS: The microvasculature of the lamellae and terminal papillae in all hoof wall regions was described in detail. Focal dilations and microvascular sphincters were a common feature. In contrast to former investigations, true arteriovenous anastomoses were detected at the base of the primary lamellae and the terminal papillae only, while thoroughfare channels proved a regular element within the microvasculature of the wall proper. Bicuspid venous valves were detected as regular feature. For the first time, the alpha-smooth muscle actin-reactivity of the microvascularisation in the hoof wall was systematically assessed, verifying its specialised vasomotor devices. CONCLUSIONS: The vasculature of the hoof wall displays specific angio-adaptations to high pressure and tensile load.
Estimating Life Expectancy and Lifetime Healthcare Costs for Alzheimer’s Disease in Taiwan: Does the Age of Disease Onset Matter?
Authors: Yeh Tian-Shin , Wang Jung-Der , Ku Li-Jung Elizabeth 
Published: November 2019

Background: People with early onset Alzheimer’s disease (EOAD) seem to suffer greater impact. But there is a lack of population-based studies on loss of life expectancy (LE) and lifetime healthcare costs. Objectives: We conducted this study to estimate LE, expected years of life lost (EYLL), and lifetime healthcare costs for Alzheimer’s disease (AD) in Taiwan stratified by onset age and gender, using a method which integrates the product of the survival function and the mean cost function over a lifetime horizon. Methods: We linked the National Health Insurance datasets with the National Mortality Registry and extrapolated the survival to lifetime to estimate the mean cumulative costs since the date of the first AD diagnosis using medical claims between 2001 and 2012. Results: A total of 21,615 mild to moderate AD patients (including 20,358 late-onset (LOAD) and 1,257 EOAD) were recruited. The average onset age for EOAD was 61 years old, while that of LOAD was 78. Although the LE of EOAD was 4.8 years longer than that of LOAD due to younger age, the EYLL for the former was 8.7 years versus 1.7 years for the latter. EOAD also had higher lifetime healthcare costs than the LOAD group (USD$37,957±2,403 versus 33,809±786). Conclusions: Since EOAD patients had both higher EYLL and lifetime healthcare costs than LOAD, future studies should pay more attention to the needs of EOAD patients.
Methods and Early Recruitment of a Community-Based Study of Cognitive Impairment Among Mexican Americans and Non-Hispanic Whites: The BASIC-Cognitive Study
Authors: Briceño Emily M. , Mehdipanah Roshanak , Gonzales Xavier , Heeringa Steven , Levine Deborah A. , Langa Kenneth M. , Garcia Nelda , Longoria Ruth , Morgenstern Lewis B. 
Published: November 2019

Background: As the Mexican American (MA) population grows and ages, there is an urgent need to estimate the prevalence of cognitive impairment or dementia (CID), cognitive trajectories, and identify community resource needs. The Brain Attack Surveillance in Corpus Christi (BASIC)-Cognitive project is a population-based study to address these issues among older MAs and non-Hispanic whites (NHW) and their informal care providers. Objective: Present the methodology and initial recruitment findings for the BASIC-Cognitive project. Method: Random, door-to-door case ascertainment is used in Nueces County, Texas, to recruit community-dwelling and nursing home residents ≥65 and informal care providers. Households are identified from a two-stage area probability sample, using Census data to aim for equal balance of MAs and NHWs. Individuals with cognitive screens indicative of possible CID complete neuropsychological assessment (Harmonized Cognitive Assessment Protocol from the Health and Retirement Study). Informal care providers complete comprehensive interview and needs assessment. Study pairs repeat procedures at 2-year follow-up. Asset and concept mapping are performed to identify community resources and study care providers’ perceptions of needs for individuals with CID. Results: 1,030 age-eligible households were identified, or 27% of households for whom age could be determined. 1,320 individuals were age-eligible, corresponding to 1.3 adults per eligible household. Initial recruitment yielded robust participation in the MA eligible population (60% of 689 individuals that completed cognitive screening). Conclusion: The BASIC-Cognitive study will provide critical information regarding the prevalence of CID in MAs, the impact of caregiving, and allocation of community resources to meet the needs of this population.
The Use of Opioids and Antipsychotics in Elderly with Dementia – Have Opioids Replaced Antipsychotics in Treating Behavioral Symptoms in Dementia?
Authors: Jensen-Dahm Christina , Christensen Ane Nørgaard , Gasse Christiane , Waldemar Gunhild 
Published: November 2019

Background: Opioids are used with increasing frequency. Elderly with dementia are prescribed opioids more frequent than elderly without. One possible explanation is that opioids may be used not only to treat pain but also behavioral symptoms. Objective: To test the hypothesis that strong opioid use, especially transdermal formulations, had increased, especially in elderly with dementia, in parallel with a decrease in antipsychotic use. Methods: Population-based cross-sectional study conducted using nationwide Danish registers with data on Denmark’s entire elderly population age ≥65 (2000: n = 802,106; 2015: n = 1,056,476). The registers were used to identify elderly with and without dementia and filled prescriptions for opioids and antipsychotics. Annual prevalence of opioid and antipsychotic use from 2000–2015 was calculated. Results: Prevalence of opioid use increased by 35% (24.2 to 32.5%) among elderly with dementia and by 13% among elderly without (14.9 to 16.8%) from 2000–2015. The disproportionate increase in opioid use among elderly with dementia was mainly driven by an increase in strong opioids (dementia: 11.7 to 23.1%; without dementia: 5.9 to 7.4%). Use of antipsychotics decreased during the same period (dementia: 31.3 to 19.3%; no dementia: 4.5 to 2.7%). Conclusion: From 2000–2015, use of opioids among the elderly increased with a disproportionately higher increase among elderly with dementia. The parallel decrease in the use of antipsychotics may suggest that opioids to some extent have replaced antipsychotics in managing behavioral symptoms, despite safety concerns and lack of evidence for effect of opioids. Future research should focus on potential risks associated with increased opioid use.
Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors: Tarraf Wassim , Kaplan Robert , Daviglus Martha , Gallo Linda C. , Schneiderman Neil , Penedo Frank J. , Perreira Krista M. , Lamar Melissa , Chai Albert , Vásquez Priscilla M. , González Hector M. 
Published: November 2019

Background: Cardiovascular disease is linked to cognitive decline and disorders (e.g., dementia). The evidence is based largely on older non-Latino White cohorts. Objective: Examine the association between global vascular risk and cognitive function among Hispanics/Latinos in the United States. Methods: We used data from a large sample of stroke- and cardiovascular disease-free, middle-aged and older Hispanics/Latinos with diverse backgrounds ( n=7,650) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We compared associations between two measures of cardiovascular risk (CVR), the Framingham Cardiovascular Risk Score (FCRS) and the multiethnic Global Vascular Risk Score (GVRS), and cognitive performance using measures of global and domain specific cognitive function, and tested for modification by sex and age. Results: Higher FCRS and GVRS were associated with lower global cognition and higher probability of low mental status, after covariates adjustment. Both CVR indices were associated with lower performances in learning and memory, verbal fluency, and psychomotor speed. Higher GVRS presented stronger associations with lower cognitive function compared to the FCRS. Women and younger age (45–64 years) exhibited more pronounced associations between higher CVR and worse cognition, particularly so with the GVRS. Discussion: CVR is also a risk for compromised cognitive function and evident in middle-age among Hispanics/Latinos. The multiethnic GVRS, tailored to specific risks based on racial/ethnic background, is feasible to use in primary care settings and can provide important insight on cognitive risk. Even modest shifts in population toward cardiovascular health in the high-risk Hispanic/Latino population can have important positive impacts on healthy cognitive aging.
Metabolic Network Topology of Alzheimer’s Disease and Dementia with Lewy Bodies Generated Using Fluorodeoxyglucose Positron Emission Tomography
Authors: Imai Masamichi , Tanaka Mika , Sakata Muneyuki , Wagatsuma Kei , Tago Tetsuro , Toyohara Jun , Sengoku Renpei , Nishina Yuji , Kanemaru Kazutomi , Ishibashi Kenji , Murayama Shigeo , Ishii Kenji 
Published: November 2019

Background: Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are often misdiagnosed with each other because of similar symptoms including progressive memory loss. The metabolic network topology that describes inter-regional metabolic connections can be generated using fluorodeoxyglucose positron emission tomography (FDG-PET) data with the graph-theoretical method. We hypothesized that different metabolic connectivity underlies the symptoms of AD patients, DLB patients, and cognitively normal (CN) individuals. Objective: This study aimed to generate metabolic connectivity using FDG-PET data and assess the network topology to differentiate AD patients, DLB patients, and CN individuals. Methods: This study included 45 AD patients, 18 DLB patients, and 142 CN controls. We analyzed FDG-PET data using the graph-theoretical method and generated the network topology in AD patients, DLB patients, and CN individuals. We statistically assessed the topology with global and nodal parameters. Results: The whole metabolic network was preserved in CN; however, diffusely decreased connection was found in AD and partially but more deeply decreased connection was observed in DLB. The metabolic topology revealed that the right posterior cingulate and the left transverse temporal gyrus were significantly different between AD and DLB. Conclusion: The present findings indicate that metabolic connectivity decreased in both AD and DLB, compared with CN. DLB was characterized restricted but deeper stereotyped network disruption compared with AD. The right posterior cingulate and the left transverse temporal gyrus are significant regions in the metabolic connectivity for differentiating AD from DLB.
Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder
Authors: Elias Alby , Cummins Tia , Lamb Fiona , Tyrrell Regan , Dore Vincent , Williams Rob , Rosenfeld Jeffrey V. , Hopwood Malcolm , Villemagne Victor L. , Rowe Christopher C. 
Published: November 2019

Background: Epidemiological studies suggest a relationship between posttraumatic stress disorder (PTSD) and dementia. Objective: This study assessed whether Alzheimer’s disease (AD) imaging biomarkers were elevated in Vietnam veterans with PTSD. Methods: The study compared cognition, amyloid-β, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician-Administered PTSD Scale. Results: The PTSD group had significantly lower education, predicted premorbid IQ, total intracranial volume, and Montreal Cognitive Assessment score compared with the controls. There was no difference between the two groups in the imaging or genetic biomarkers for AD. Conclusion: Our findings do not support an association between AD pathology and PTSD of up to 50 years duration. Measures to assess cognitive reserve, a factor that may delay the onset of dementia, were lower in the PTSD group compared with the controls and this may account for the previously observed higher incidence of dementia with PTSD.
Volvulus with intestinal malrotation hiding a near-total intestinal aganglionosis: Case report
Authors: Kerkeni Y. , Hannachi W. , Hamzaoui M. 
Published: November 2019

Total colonic aganglionosis occurring together with malrotation is a rare occurrence and may pose diagnostic and management dilemmas for the pediatric surgeon. We report the case of a new born, who was operated at the age of three days for malrotation with volvulus, treated by Ladd procedure. Postoperatively, we noticed persistent abdominal distension and emission of a small amount of meconium every 4 to 5 days. The barium enema showed a non-functional microcolon. Surgical exploration on the 24th day found an ileo-ileal transition zone located 60 cm distal to the ligament of Treitz. Extemporaneous biopsies from the colon and mid-ileum confirmed the absence of ganglion cells. We performed an ileostomy at 50 cm from duodeno-jejunal flexure. Unfortunately, the patient succumbed to nosocomial infection at 33 days of age. This case was a challenging scenario for us where a diagnosis of complicated malrotation had obscured the Hirschsprung’s disease.
Percutaneous retrieval of fractured intravascular catheters in premature infants
Authors: Rothman A. , Jaiswal V. , Evans W.N. , Restrepo H. , Galindo A. 
Published: November 2019

BACKGROUND: Premature infants often require long-term indwelling intravascular catheters. Occasionally, catheters fracture and migrate into cardiovascular structures, risking perforation, infection, thrombosis, and interference with cardiac and valve function. This case series describes our experience with percutaneous retrieval of broken intravascular catheters. METHODS: A gooseneck micro-snare was used to retrieve fractured catheters in four premature infants, weighing between 840 and 1930 grams. RESULTS: All procedures were successful without complications. CONCLUSIONS: Gooseneck-snare retrieval of broken indwelling intravascular catheters can be performed safely and successfully in premature infants even those that weigh less than 1000 grams.
Laktasyondaki Keçilerde Lökosit CaSR Gen Ekspresyon Seviyesi İle Plazma Kalsiyum Seviyesinin Belirlenmesi
Authors: DALKIRAN Sevda , YAKAN Akın 
Published: November 2019

Süt verimi keçi yetiştiriciliğinde büyük öneme
sahiptir. Sütün içeriğinde bulunan kalsiyum insan sağlığı için önemlidir. Kalsiyum
hücre membran geçirgenliği, hormonların salınımı, enzim aktivitesi gibi birçok
fizyolojik olayda görev almaktadır. Metabolizma bakımından değerlendirildiğinde
laktasyon döneminde süt verimine bağlı olarak kalsiyum ihtiyacı artmaktadır.
Kalsiyum düzeyi ise önemli oranda Kalsiyuma Duyarlı Reseptör (CaSR) geni
aracılığıyla düzenlenmektedir. Bu çalışmada laktasyondaki Damascus keçilerinde
CaSR geni ekspresyon seviyesi ile kan kalsiyum seviyesi ölçülerek laktasyon ile
aralarındaki ilişki araştırılmıştır. CaSR geni ekspresyon seviyesi RT-qPCR ile
ölçülürken plazma kalsiyum seviyesi mikroplazma atomik emisyon spektrofotometresi
(MP- AES) ile ölçülmüştür. Laktasyonun 1. ayına göre 3., 5. ve 7. aylarında
CaSR genine ait ekspresyon seviyesinin önemli derecede azaldığı tespit
edilmiştir. Laktasyonun 1. ve 3. aylarına göre diğer aylarda kalsiyum seviyelerinde
önemli derecede azalma tespit edilmiştir. Plazma kalsiyum miktarındaki azalma CaSR
geninin ekspresyon seviyesindeki azalma ile uyumlu olduğu tespit edilmiştir. Böylece
laktasyon ile kaybolan kalsiyumun plazmadaki düşüşünü engellemek için
metabolizmanın koruma refleksi oluşturarak CaSR ekspresyonunu azalttığı
görülmüştür. Yapılan bu çalışmayla laktasyon dönemindeki keçilerde süt ile
birlikte ortaya çıkan kalsiyum kaybının kandaki regülasyonunu CaSR geni ile
sağlandığı tespit edilmiştir.&nbsp;
Knowledge Management dalam Organisasi
Authors: Widyatmika Made Adi , Putra Tjokorda , Indriani Made Novia 
Published: November 2019

Knowledge Management (KM) adalah suatu pengorganisasian pengetahuan yang dimiliki oleh individu dalam sebuah organisasi. Dengan knowledge management, suatu pengetahuan yang dimiliki individu akan dapat menjadi pengetahuan organisasi sehingga bermanfaat bagi organisasi terutama dalam meningkatkan daya saing bisnis organisasi. Dengan banyaknya knowledge management yang telah diterapkan di beberapa organisasi di Indonesia , maka perlu dilakukan review kembali mengenai penelitian terkait bagaimana implementasi knowledge management pada organisasi komersial dan organisasi pendidikan. Metode penelitian yang digunakan adalah observasi dan study literatur. Dari hasil penelitian tersebut didapat kan bahwa implementasi knowledge management pada organisasi komersial PT Telkom Indonesia berdasarkan pengukuran kinerja dinyatakan sedang yaitu bahwa pengetahuan dalam kampiun belum memberikan hasil kinerja pegawai menjadi lebih maksimal. Sedangkan implementasi knowledge management pada organisasi pendidikan ITB Bandung, menunjukkan bahwa kebijakan teknis mendukung untuk manajemen pengetahuan digambarkan dalam visi, misi dan tujuan , penerapan manajemen pengetahuan dilihat dari aspek orang dilakukan melalui pengembangan kompetensi sumber daya manusia, proses manajemen pengetahuan sejalan dengan "Tridharma Perguruan Tinggi dengan penggunaan teknologi informasi. Untuk membuat pengetahuan tacit baru dapat dilakukan dengan beberapa cara, antara lain melalui pertemuan, lokakarya, seminar, dan lain-lain.
Efektifitas Pelaksanaan Eksekusi Denda Tilang Di Kabupaten Pulang Pisau
Authors: Yusuf Muhamad , Nurcahyanti Turyan Indah 
Published: November 2019

This research aims to determine the mechanism of execution of fines of money from the Pulang Pisau Affairs attorney in the case of criminal acts of traffic violations, as well as to find out what matters for the Prosecutor State of the Pulang Pisau in carrying out its duties or roles as an execution of a fine of money in a criminal act of traffic violations, and knowing the actions taken as a solution to the problem. This research uses qualitative research methods.
The results of this research can be known the effectiveness of the execution of fine speeding tickets in the state Attorney Pulang Pisau Office has shown positive results, this is demonstrated by the number of cases that have been executed as a percentage of Bigger than the ticketed thing that is still in arrears. However, the arrears that have not been completed can still require follow-up completion, given the magnitude of potential state acceptance that can be obtained from the payment of fine ticketed. The obstacles faced by the State prosecutor's Office in implementing the execution of fine ticketed are among other tickets that are not immediately paid by the violators, because of the ticket violators who are not residents originating from the Pulang Pisau but only riders passing through the Pulang Pisau; Violators reasoned if the busy factor had not attended trial; As well as the amount of workload received by the employees makes the handling of speeding things less efficient.
Implementasi Program Simpan Pinjam Perempuan Di Desa Mendawai Kecamatan Mendawai Kabupaten Katingan
Authors: Masrukin Masrukin , Fitriadi Nur Akhsan 
Published: November 2019

This study focused on implementing the Program of the women's borrow in Mendawai village, Mendawai District, Katingan Regency. The purpose of this research is to know how the implementation of the Save women's Program and the supporting factors and supporters of the women's Save borrow program in the village Mendawai District Mendawai District Katingan. In the study that raised the title of implementation of the women's Save lending Program, the method of research was taken using qualitative methods. The data obtained in this research is gathered through interviews, observations, and documentation.
The results showed that in the program of the women's borrowing in Mendawai village, Mendawai District, Katingan District, there are constraints of UPK and the members of the loan. The advice that researchers can give to the parties to the implementation of this female borrow is (1) It is expected to be aware of the constraints in implementing the women's Save (SPP) program for the Women's Save loan ( The SPP) can go well. (2) Hopefully UPK should be able to put the data of each group to the computer so that if the group will make loans in the second period of the community group no longer have to complete the requirements such as the first period (3) be expected For the problem of facility should UPK also pay attention to office conditions as supporting the performance of its members.