bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional jejunostomy in esophagectomy for cancer, a national register-based cohort study of associations with postoperative outcomes and survival
Authors: Holmén Anders , Hayami Masaru , Szabo Eva , Rouvelas Ioannis , Agustsson Thorhallur , Klevebro Fredrik 
Published: November 2020

Abstract
Purpose
Insertion of a nutritional jejunostomy in conjunction with esophagectomy is performed with the intention to decrease the risk for postoperative malnutrition and improve recovery without adding significant catheter-related complications. However, previous research has shown no clear benefit and there is currently no consensus of practice.

Methods
All patients treated with esophagectomy due to cancer during the period 2006–2017 reported in the Swedish National Register for Esophageal and Gastric Cancer were included in this register-based cohort study from a national database. Patients were stratified into two groups: esophagectomy alone and esophagectomy with jejunostomy.

Results
A total of 847 patients (45.27%) had no jejunostomy inserted while 1024 patients (54.73%) were treated with jejunostomy. The groups were comparable, but some differences were seen in histological tumor type and tumor stage between the groups. No significant differences in length of hospital stay, postoperative surgical complications, Clavien-Dindo score, or 90-day mortality rate were seen. There was no evidence of increased risk for significant jejunostomy-related complications. Patients in the jejunostomy group with anastomotic leaks had a statistically significant lower risk for severe morbidity defined as Clavien-Dindo score ≥ IIIb (adjusted odds ratio 0.19, 95% CI: 0.04–0.94, P = 0.041) compared to patients with anastomotic leaks and no jejunostomy.

Conclusion
A nutritional jejunostomy is a safe method for early postoperative enteral nutrition which might decrease the risk for severe outcomes in patients with anastomotic leaks. Nutritional jejunostomy should be considered for patients undergoing curative intended surgery for esophageal and gastro-esophageal junction cancer.
Vom Elfenbeinturm auf die Straße und zurück – Kompass für ein solidarisches Quartier
Authors: Hellriegel Maximilian , Schmitt Pacífico Sara 
Published: November 2020

ZusammenfassungVor dem Hintergrund der zunehmenden Veränderung des städtischen Lebensumfeldes durch Gentrifizierung, investorenfreundliche Stadtpolitik, Privatisierung öffentlicher Räume, Einsparung öffentlicher Investitionen und den Abbau demokratischer Beteiligungsinstrumente haben wir uns gefragt: Wie könnte eine solidarische Stadt der Zukunft aussehen? Welche Gegenentwürfe zu aktuell herrschenden Paradigmen in der Stadtentwicklung zeigen uns Wege aus der Alternativlosigkeit hin zu einer solidarischen Praxis auf Quartiersebene? Im Rahmen einer angewandten kritischen Geografie möchten wir zeigen, dass es eine Vielzahl an Projekten und Initiativen gibt, die die Kreativlosigkeit, zu der uns der Neoliberalismus erzogen hat, durchbrechen und an konkreten Ideen und deren praktischer Umsetzung arbeiten. Als theoretische Annäherung dafür setzen wir uns mit Utopien und deren Potenzialen für eine politische Praxis auseinander. Da wir selbst im Kontext stadtpolitischer Gruppen engagiert sind, nutzen wir die aktivistische Stadtforschung als methodischen Rahmen unserer Forschung. Daraus entstanden ist ein Faltblatt, der „Kompass für ein solidarisches Quartier“, welcher als aktivistisches Werkzeug und Ideengeber für die konkrete Umsetzung transformativer Stadtpolitik dienen soll.
Sexual preference for prepubescent children is associated with enhanced processing of child faces in juveniles
Authors: Speer Lara , Schuler Miriam , Keil Julian , Moran James K. , Pantazidis Pierre , Amelung Till , Florack Jakob , Beier Klaus M. , Senkowski Daniel 
Published: November 2020

AbstractChild sexual abuse offences (CSOs) represent a severe ethical and socioeconomic burden for society. Juveniles with a sexual preference for prepubescent children (PP) commit a large percentage of CSOs, but have been widely neglected in neuroscience research. Aberrant neural responses to face stimuli have been observed in men with pedophilic interest. Thus far, it is unknown whether such aberrations exist already in PP. A passive face-viewing paradigm, including the presentation of child and adult faces, was deployed and high-density electroencephalography data were recorded. The study group comprised 25 PP and the control group involved 22 juveniles with age-adequate sexual preference. Attractiveness ratings and evoked brain responses were obtained for the face stimuli. An aberrant pattern of attractiveness ratings for child vs. adult faces was found in the PP group. Moreover, elevated occipital P1 amplitudes were observed for adult vs. child faces in both groups. At longer latency (340–426 ms), a stronger negative deflection to child vs. adult faces, which was source localized in higher visual, parietal and frontal regions, was specifically observed in the PP group. Our study provides evidence for enhanced neural processing of child face stimuli in PP, which might reflect elevated attention capture of face stimuli depicting members from the sexually preferred age group. This study expands our understanding of the neural foundations underlying sexual interest in prepubescent children and provides a promising path for the uncovering of objective biomarkers of sexual responsiveness to childlike body schemes in juveniles.
Exploring the effect of an augmented reality literacy programme for reading and spelling difficulties for children diagnosed with ADHD
Authors: Tosto Crispino , Hasegawa Tomonori , Mangina Eleni , Chifari Antonella , Treacy Rita , Merlo Gianluca , Chiazzese Giuseppe 
Published: November 2020

AbstractChildren diagnosed with attention deficit hyperactivity disorder (ADHD) experience a variety of difficulties related to three primary symptoms: hyperactivity, inattention and impulsivity. The most common type of ADHD has a combination of all three symptom areas. These core symptoms may negatively impact the academic and social performance of children throughout their school life. The AHA (ADHD-Augmented) project focused specifically on the impact of digital technologies’ intervention on literacy skills of children that participated in the pilot study and were diagnosed with ADHD prior to the intervention. Existing research has shown that augmented reality (AR) can improve academic outcomes by stimulating pupils’ attention. AHA project aimed at implementing an evidence-based intervention to improve ADHD children’s reading and spelling abilities through the enhancement of an existing literacy programme with AR functionality. The present paper reports preliminary findings of the pilot study aimed at evaluating the effectiveness of the AHA system in promoting the acquisition of literacy skills in a sample of children diagnosed with ADHD compared to the literacy programme as usual. Background information on the main characteristics and difficulties related to the teaching and learning process associated with children diagnosed with ADHD are first introduced; the design and methodology of the AHA project intervention are also described. The preliminary findings have shown that AHA project succeeded in delivering an AR solution within an existing online literacy programme, which integrates a set of specific technologies and supports interactive educational content, services, assessment, and feedback.
Non-equilibrium approach for binding free energies in cyclodextrins in SAMPL7: force fields and software
Authors: Khalak Yuriy , Tresadern Gary , de Groot Bert L. , Gapsys Vytautas 
Published: November 2020

AbstractIn the current work we report on our participation in the SAMPL7 challenge calculating absolute free energies of the host–guest systems, where 2 guest molecules were probed against 9 hosts-cyclodextrin and its derivatives. Our submission was based on the non-equilibrium free energy calculation protocol utilizing an averaged consensus result from two force fields (GAFF and CGenFF). The submitted prediction achieved accuracy of$${1.38}\,\hbox {kcal}/\hbox {mol}$$1.38kcal/molin terms of the unsigned error averaged over the whole dataset. Subsequently, we further report on the underlying reasons for discrepancies between our calculations and another submission to the SAMPL7 challenge which employed a similar methodology, but disparate ligand and water force fields. As a result we have uncovered a number of issues in the dihedral parameter definition of the GAFF 2 force field. In addition, we identified particular cases in the molecular topologies where different software packages had a different interpretation of the same force field. This latter observation might be of particular relevance for systematic comparisons of molecular simulation software packages. The aforementioned factors have an influence on the final free energy estimates and need to be considered when performing alchemical calculations.
Laparoscopic Heller Myotomy and Dor Fundoplication for the Treatment of Esophageal Achalasia After Sleeve Gastrectomy—a Video Vignette
Authors: Aiolfi Alberto , Foschi Diego , Zappa Marco Antonio , Dell’Era Alessandra , Bareggi Emilia , Rausa Emanuele , Micheletto Giancarlo , Bona Davide 
Published: November 2020

Abstract
Purpose
Esophageal dysmotility and disorders of the lower esophageal sphincter are well documented in morbidly obese patients. Esophageal achalasia has been reported in up to 1% of obese patients but the development of such esophageal motility disorder after laparoscopic sleeve gastrectomy (LSG) is extremely rare. The purpose of this video was to demonstrate the management of a type II esophageal achalasia diagnosed in a 46-year-old female patient 4-year after LSG.

Materials and Methods
An intraoperative video has been anonymized and edited to demonstrate the feasibility of laparoscopic Heller myotomy and anterior Dor fundoplication on the mentioned patient.

Results
The operation started with the section of the perigastric adhesions. Proceeding in a clockwise direction, the esophagogastric junction, the anterior esophageal wall, and the His angle were freed. A residual slightly dilated fundus was found and isolated. After mobilization of the distal esophagus and identification of the anterior vagus nerve, a “hockey stick” myotomy was carried out for 6 cm on the esophagus and for 2 cm on the gastric side. An anterior Dor fundoplication was fashioned using the residual gastric fundus.

Conclusion
Esophageal achalasia in patients that previously underwent LSG is exceptional but should always be suspected in case of pathognomonic symptoms onset. In tertiary referral centers, laparoscopic Heller myotomy and, if technically feasible, an anterior Dor fundoplication seem safe and effective to relieve gastroesophageal outflow obstruction and prevent gastroesophageal reflux.
Trends in HbA1c and other biochemical outcomes of individuals with newly diagnosed type 1 diabetes
Authors: O’Carroll-Lolait A. , Urwin A. , Doughty I. , Schofield J. , Thabit H , Leelarathna L. 
Published: November 2020

AbstractBackgroundThere is limited data on glycaemic control and cardiovascular risk factor management in newly diagnosed individuals with type 1 diabetes in the first 2 years.MethodsRetrospective, single centre study from the North West of England, newly diagnosed with type 1 diabetes between 2014 and 2018 (n= 58). HbA1c, blood pressure, lipids and body mass index (BMI) data were collected from electronic patient records from the time of diagnosis until the end of 2 years, stratified by age 16–24 years or ≥ 25 years at presentation.ResultsFor those aged 16–24 years (n= 31), median (IQR), HbA1c improved at 6 months from 83 (63–93) to 51.5 (46–75) mmol/mol (p= 0.001) and remained stable 6–24 months. For those ≥ 25 years (n= 27), HbA1c declined from 91 (70–107) to 65 (50–89) mmol/mol, (p< 0.01) at 6 months and declined further to 52 mmol/mol (44–70) at 24 months. At 24 months, 27.8% of all individuals had an HbA1c ≥ 69 mmol/mol. Approximately, a third met LDL (< 2 mmol/L) and total cholesterol (< 4 mmol/L) targets. A total of 58.6% of individuals were overweight/obese (BMI > 25 kg/m2) at 24 months compared to 45.8% at baseline. There were no significant blood pressure changes during the follow-up.ConclusionsIn both age groups, significant improvement of HbA1c occurred within the first 6 months of diagnosis with no statistical difference between the two groups at any of the time points up to 24 months. Despite significant improvements in HbA1c, majority had levels > 53 mmol/mol at 24 months. Alongside the high incidence of obesity and dyslipidaemia, our data support the need for further intensification of therapy from diagnosis of type 1 diabetes.
Words of encouragement: how praise delivered by a social robot changes children’s mindset for learning
Authors: Davison Daniel P. , Wijnen Frances M. , Charisi Vicky , van der Meij Jan , Reidsma Dennis , Evers Vanessa 
Published: November 2020

AbstractThis paper describes a longitudinal study in which children could interact unsupervised and at their own initiative with a fully autonomous computer aided learning (CAL) system situated in their classroom. The focus of this study was to investigate how the mindset of children is affected when delivering effort-related praise through a social robot. We deployed two versions: a CAL system that delivered praise through headphones only, and an otherwise identical CAL system that was extended with a social robot to deliver the praise. A total of 44 children interacted repeatedly with the CAL system in two consecutive learning tasks over the course of approximately four months. Overall, the results show that the participating children experienced a significant change in mindset. The effort-related praise that was delivered by a social robot seemed to have had a positive effect on children’s mindset, compared to the regular CAL system where we did not see a significant effect.
Highly Accurate, But Still Discriminatory
Authors: Köchling Alina , Riazy Shirin , Wehner Marius Claus , Simbeck Katharina 
Published: November 2020

AbstractThe study aims to identify whether algorithmic decision making leads to unfair (i.e., unequal) treatment of certain protected groups in the recruitment context. Firms increasingly implement algorithmic decision making to save costs and increase efficiency. Moreover, algorithmic decision making is considered to be fairer than human decisions due to social prejudices. Recent publications, however, imply that the fairness of algorithmic decision making is not necessarily given. Therefore, to investigate this further, highly accurate algorithms were used to analyze a pre-existing data set of 10,000 video clips of individuals in self-presentation settings. The analysis shows that the under-representation concerning gender and ethnicity in the training data set leads to an unpredictable overestimation and/or underestimation of the likelihood of inviting representatives of these groups to a job interview. Furthermore, algorithms replicate the existing inequalities in the data set. Firms have to be careful when implementing algorithmic video analysis during recruitment as biases occur if the underlying training data set is unbalanced.
Predicting the relationships between gut microbiota and mental disorders with knowledge graphs
Authors: Liu Ting , Pan Xueli , Wang Xu , Feenstra K. Anton , Heringa Jaap , Huang Zhisheng 
Published: November 2020

AbstractGut microbiota produce and modulate the production of neurotransmitters which have been implicated in mental disorders. Neurotransmitters may act as ‘matchmaker’ between gut microbiota imbalance and mental disorders. Most of the relevant research effort goes into the relationship between gut microbiota and neurotransmitters and the other between neurotransmitters and mental disorders, while few studies collect and analyze the dispersed research results in systematic ways. We therefore gather the dispersed results that in the existing studies into a structured knowledge base for identifying and predicting the potential relationships between gut microbiota and mental disorders. In this study, we propose to construct a gut microbiota knowledge graph for mental disorder, which named as MiKG4MD. It is extendable by linking to future ontologies by just adding new relationships between existing information and new entities. This extendibility is emphasized for the integration with existing popular ontologies/terminologies, e.g. UMLS, MeSH, and KEGG. We demonstrate the performance of MiKG4MD with three SPARQL query test cases. Results show that the MiKG4MD knowledge graph is an effective method to predict the relationships between gut microbiota and mental disorders.
Delay recovery model for high-speed trains with compressed train dwell time and running time
Authors: Hou Yafei , Wen Chao , Huang Ping , Fu Liping , Jiang Chaozhe 
Published: November 2020

AbstractModeling the application of train operation adjustment actions to recover from delays is of great importance to supporting the decision-making of dispatchers. In this study, the effects of two train operation adjustment actions on train delay recovery were explored using train operation records from scheduled and actual train timetables. First, the modeling data were sorted to extract the possible influencing factors under two typical train operation adjustment actions, namely the compression of the train dwell time at stations and the compression of the train running time in sections. Stepwise regression methods were then employed to determine the importance of the influencing factors corresponding to the train delay recovery time, namely the delay time, the scheduled supplement time, the running interval, the occurrence time, and the place where the delay occurred, under the two train operation adjustment actions. Finally, the gradient-boosted regression tree (GBRT) algorithm was applied to construct a delay recovery model to predict the delay recovery effects of the train operation adjustment actions. A comparison of the prediction results of the GBRT model with those of a random forest model confirmed the better performance of the GBRT prediction model.
Characteristics and geological significance of germanium in Taiyuan coal formation of Huainan Coalfield, Anhui, China
Authors: Wu Dun , Zhang Wenyong , Liu Guijian , Zhan Run , Hu Guangqing 
Published: November 2020

AbstractHN-1# is the first fully working coring well of the Taiyuan Formation (Ty) in the Huinan Coalfield and exploration studies are currently underway on the associated resources of the coal-bearing strata. The HN-1# well is located in the Fufeng thrust nappe structural belt in the south of the Huainan Coalfield. Three coal samples from the Ty were collected from HN-1# and inductively-coupled plasma mass spectrometry and inductively-coupled plasma atomic emission spectrometry were used to determine the Ge content of each sample. Based on proximate and ultimate analyses, microscopy data, and analyses of the ash products, some important findings were made. The Ty coal samples had a relatively high total sulfur (St,d) content (4.24%), thus the coal was considered to be a lower ranked coal (high volatility bituminous coal), which also had a low coal ash composition index (k, 1.87). Collodetrinite was the main submaceral of the Ty coal. Small amounts of pyrite particles were found in the coal seams of the Ty, while the contents of pyrite and algae in the top and bottom sections of the coal seam were relatively high, which meant that the swampy peat conditions which existed during the formation of the coal seams were affected by seawater; also the degree of mineralization of the coal seam was relatively high, which is consistent with reducing conditions in a coastal environment setting. Atomic force microscopy (AFM) experiments showed that the modes of occurrence of Ge in the Ty coal were mainly those for organic-bound and adsorbed Ge species. The organic carbon isotope values for the Ty coal ranged from − 24.1‰ to − 23.8‰, with an average value of − 24.0‰, which is equivalent to the value for terrestrial plants (average value − 24.0‰). The Ge content of the Ty coal was 13.57 mg/kg. The Ge content was negatively correlated with volatile matter and the ash yield.
The development of genome editing tools as powerful techniques with versatile applications in biotechnology and medicine: CRISPR/Cas9, ZnF and TALE nucleases, RNA interference, and Cre/loxP
Authors: Schulze Sabrina , Lammers Michael 
Published: November 2020

AbstractThe huge progress in whole genome sequencing (genomic revolution) methods including next generation sequencing (NGS) techniques allows one to obtain data on genome sequences of all organisms, ranging from bacteria to plants to mammals, within hours to days (era of whole genome/exome sequencing) (Goodwin et al. in Nat Rev Genet 17:333–351, 2016; Levy and Myers in Annu Rev Genomics Hum Genet 17:95–115, 2016; Giani et al. in Comput Struct Biotechnol J 18:9–19, 2020). Today, within the era of functional genomics the highest goal is to transfer this huge amount of sequencing data into information of functional and clinical relevance (genome annotation project). The World Health Organization (WHO) estimates that more than 10,000 diseases in humans are monogenic, i.e., that these diseases are caused by mutations within single genes (Jackson et al. in Essays Biochem 62:643–723, 2018). NGS technologies are continuously improving while our knowledge on genetic mutations driving the development of diseases is also still emerging (Giani et al. in Comput Struct Biotechnol J 18:9–19, 2020). It would be desirable to have tools that allow one to correct these genetic mutations, so-called genome editing tools. Apart from applications in biotechnology, medicine, and agriculture, it is still not concisely understood in basic science how genotype influences phenotype. Firstly, the Cre/loxPsystem and RNA-based technologies for gene knockout or knockdown are explained. Secondly, zinc-finger (ZnF) nucleases and transcription activator-like effector nucleases (TALENs) are discussed as targeted genome editing systems. Thirdly, CRISPR/Cas is presented including outline of the discovery and mechanisms of this adaptive immune system in bacteria and archaea, structure and function of CRISPR/Cas9 and its application as a tool for genomic editing. Current developments and applications of CRISPR/Cas9 are discussed. Moreover, limitations and drawbacks of the CRISPR/Cas system are presented and questions on ethical concerns connected to application of genome editing tools are discussed.
The Anti-enlightenment Tradition as a Source of Cynicism in the European Union
Authors: Ziegler Tamas Dezso 
Published: November 2020

AbstractThis article analyses the effect of the anti-Enlightenment tradition on the functioning of the European Union. This tradition covers a lack of belief in liberal values, human rights, egalitarianism, the rule of law, individualism, tolerance, and the respectful cooperation among people. Its ideological background is not new: its existence is also the reason why scholars started to talk about post-fascism in the twenty-first century. In a number of European Union member states, where autocratic tendencies have recently been witnessed (like in Hungary or Poland), it started to dominate decision-making, while its presence is also visible elsewhere, like in the UK, Germany, and Italy. This article selects four prime examples (the rule of law backlash, refugee law, Brexit, and changes to the single market) to show how arguments containing elements of the anti-Enlightenment tradition are used in a cynical way to support partisan and oppressive politics while maintaining a seemingly inclusive façade of democratic decision-making. In the European Union, this can result in dubious, un-explained measures and great policy changes both at EU and member state level.