bluuebunny/crossref_metadata_2025_split huggingface dataset:
Claudin-3 is Frequently Overexpressed in Ovarian Cancer and Promotes Migration and Invasion
Authors: Hao Chenyuan , Liang Xiaomei , Wang Yifeng 
Published: December 2020

Abstract
ObjectiveClaudins are integral membrane proteins associated with tight junctions. Previousstudies have shown that claudin-3 (CLDN3) is frequently upregulated in epithelial ovarian cancer (EOC). The relevance of CLDN 3 responsible for the invasion and metastasis of ovarian carcinoma is unclear. The aim of the study was to investigate the suppressive effects of CLDN3 in ovarian cancer cells and normal ovarian cells.Materials and methodsOvarian cancer tissues and their adjacent nontumorous tissues were investigated in this study. The expressions of CLDN3 in these cells were detected by Western blot and Immunohistochemistry (IHC). The cellular viability was determined by MTT assay. Cell Invasive capabilities in vitro were determined by a modified Boyden chamber invasion assay. Cellular Migration capabilities were determined Using Wound-healing/Scratch Assay.ResultsThe expression of CLDN3 was 90% (18/20) in the ovarian cancer which was significantly higher than that in normal tissues (50%, 6/12) (p＜0.05). The CLDN3 protein expression was significantly suppressed in SKOV3 cells with siRNA silencing Claudin-3 gene. CLDN3 expression is associated with cellular viability. The cellular migration and invasion abilities were significantly decreased in CLDN3-knockdown SKOV3 cells compared with control cells. Upregulation of CLDN3 showed an increased metastasis ability in normal ovarian cell IOSE80.ConclusionClaudin-3 expression has been shown to promote cellular viability, migration and invasion of ovarian cells. Elucidation of the roles of CLDN3 and treatment targeting on CLDN3 in ovarian cancers might provide a new opportunity for therapy.
Economic Evaluation of Water Supplying Function of a Mountain-forest Area of Turkey: Forest Rotation Impacts
Authors: UZEL Gökhan , GURLUK Serkan , KARAER Feza 
Published: December 2020

Abstract
Background: Mountain-Forest ecosystems provide essential services within the economic system of the region and perhaps the country. These natural resources, which have many apparent or not apparent functions, are facing economic development pressures in recent years. The benefits of water provided by mountain-forest ecosystems to the downstream basin and the benefits of eliminating the adverse conditions created by rainwater are economically valuable. However, they are benefits that decision-makers often do not consider. With quality and rational forest management, these benefits can be gained much more publicly. Forest rotation, silviculture studies, economic value determination, and rational forest management taking all these into account can provide this. Methods: The Faustmann approach made essential contributions to natural resource management and especially to the economic analysis of mountain-forest ecosystems in the middle of the 19th century. Highlighting the importance of the forest area's regeneration process, Faustman gave important opinions to decision-makers about when the timber value will be suitable for rotation. Hartman developed the Faustman approach by stating that the forest area has not only timber value but also non-timber values. In this study, the function of providing water resources from the Uludag National Park (UNP) resource values examined both approaches; and three models were created. Results: The basic model where only the timber value is taken into account is the model in which the impact of the rain flow regulation service on the UNP rotation is analyzed, and all forest water services are taken into account. Here, it was taken into account that the increased water quality value due to the forest will increase by 10%. According to the first model results, the UNP must be subjected to rotation at intervals of 44 years. UNP reaches its current net value of 956 USD/Ha in 44 years. In the second model, in which the service of eliminating problems such as floods, landslides, and landslides may occur in settlements below the basin due to the retention of rainwater in forest soil, there was no effect on the rotation period. However, the stand value increased to 976 USD/year per hectare. The third model assumed that the water quality value increased by 10%; It was concluded that the rotation increased to 107 years, and the stand value per hectare this year is 147 006 USD/Year. Conclusions: The study has made important contributions to the literature. It integrates the natural resource value determination studies with the forest rotation system. Also, essential implications are made for regional decision-makers and UNP forest management. It was concluded that the necessity of increasing the business investments made to the UNP is how important the allocation, use, and development decisions of the UNP are.
Examine Employees Creativity in the Bank: A case of Commercial Bank of Ethiopia Woldia Branches
Authors: Tarko Erstu 
Published: December 2020

Abstract
The study aims to examine employees’ creativity in the bank a case of commercial bank of Ethiopia Woldia Branches. The researcher used a cross-sectional design and followed a mixed research approach. This study census method has been utilized to participate in respondents from four branches, that on duty 182 employees in commercial bank of Ethiopia. The collected data were analyzed by using multiple regression methods method after proving the quality of the data. The study finding revealed that autonomy, supervisors’ support and role ambiguity significantly affects the creativity of employees in the workplace. The remaining variables self-efficacy and job complexity have no statistically significant effect on employees’ creativity in the bank.
Determinants of Financial Management Practice: The Case of Micro and Small Enterprises in East Gojjam Zone, Ethiopia
Authors: Asres Gedefaw , Teka Beza Muche 
Published: December 2020

Abstract
PurposeFinancial management is defined as the overall arrangement for planning, directing, monitoring, organizing, and controlling of the economic resources of an organization, with a view to efficient accomplishment of the enterprise objectives. It is well recognized that financial management practice has a key reason for the success of those enterprises and it is the main issue for any business type. However, the status of effective financial management practice in developing countries especially in Ethiopia is at its infant stage. Thus, the main objective of the study is to investigate the determinants of financial management practice of micro and small enterprises in East Gojjam Zone. MethodThe type of research applied in this study is explanatory/causal/ in nature. Questionnaires were used to collect primary data. The combination of purposive stratified and systematic sampling techniques were applied to select respondents. A multiple linear regression model was used to test the casual relationship between the study variables.FindingsThe findings indicated that financial management knowledge, financial management attitude, size of enterprise, locus of control, and use of information technology have positive and significant effect on financial management practice. However, gender, owner’s age, and enterprise age have no statistically significant effect on financial management practice of micro and small enterprises.SuggestionThe study suggested that financial management experts should provide financial management training for micro and small enterprise owners/managers.
Association between Organochlorine Pesticides and Thyroid Tumors; an in-silico and in-vivo Case Control Study
Authors: Salimi Fouzieh , Asadikaram Gholamreza , Abolhassani Moslem , Nejad Hamid Zeynali , Bagheri Fatemeh , Kahnouei Masoumeh M.R. , Abbasi-jorjandi Mojtaba , Sanjari Mojgan 
Published: December 2020

Abstract
Purpose: In this study, we aimed to investigate the role of organochlorine pesticides (OCPs), in the development of thyroid tumors. Method: Seven derived OCPs measured by gas chromatography (GC), and enzyme activities of acetylcholinesterase (AChE), superoxide dismutase3 (SOD3), catalase (CAT), glutathione peroxidase3 (GPx3) and paraoxonase1 (PON1) and also malondialdehyde (MDA), total antioxidant capacity (TAC), protein carbonyl (PC), and nitric oxide (NO), as oxidative stress (OS) biomarkers were assessed in the blood of 61 patients with papillary thyroid carcinoma (PTC), 70 patients with benign thyroid nodules (BTN), and 73 healthy individuals. Furthermore, all the studied enzymes were docked against the measured OCPs. Results: The results revealed that β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4-DDT, and 4,4-DDT levels along with MDA, NO and PC levels were elevated, while AChE, SOD3, GPx3, CAT, and PON1 activities and TAC levels were decreased in the PTC and BTN groups compared with the control group. Conclusion: The results of present study indicated that OCPs might play a major role in the development of thyroid tumors by disturbing the thyroid gland through several mechanisms including generation of OS. Importantly, in-silico analysis confirmed the in vivo findings.
Comparison between Carpal Tunnel Syndrome and Individuals with Symptoms of Obsessive- Compulsive Disorder
Authors: PAPAKER Meliha GÜNDAĞ , ABDALLAH Anas , SEYİTHANOĞLU Mehmet Hakan , CAN Engin , PAK Aygül TANTİK , ŞENGÜL Yıldızhan 
Published: December 2020

Abstract
Objective: Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment neuropathy and is seen in 3 % of the general population. The aim to this study was examine the relationship between the symptoms of cleaning compulsion with using Moudsley obsessive compulsive inventory ( MOCI ) and patients with CTS. Methods: Sixty patients with CTS and 60 healty controls were evaluated in Bezmialem Vakif University Faculty of Medicine Neurosurgery Clinic. Neurological examination, Electrophysiological findings, the presence of neuropathic pain evaluated by the Leeds assessment of neuropathic symptoms and signs (LANSS) , the symptoms of obsessive- compulsive disorder using with MOCI and anxiety levels assessed by the Beck Anxiety Inventory (BAI) were evaluated. Results: No statistically significant relationship was observed between anxiety levels and CTS (p › 0.005). No statistically significant relationship was found MOCI rumination, control and doubting subscale scores (p › 0.005). Patient group had higher MOCI cleaning subscale scores than the control group and the difference was statistically significant (p=0.008). Patient group had higher MOCI slowness subscale scores than the control group and the difference was statistically significant (p=0.004). Conclusion: Increased wrist movement in people that have the symptoms of compulsive cleaning is associated with the risk of CTS. Our study show that a reduction of high level of wrist flexion-extansion movements may decrease the new CTS cases.
A Case Report of a Soldier with Combined Injuries to the Trachea and Esophagus After Blunt Neck Trauma Successfully Treated Through an Emergency Operation
Authors: Wang Zheng , Shi Zhengliang , Xu Yijun , Zhang Xun 
Published: December 2020

Abstract
Background: Survival following blunt neck trauma that results in a combination of tracheal plus esophageal injury is unusual. Here we describe a case of young soldier who suffered combined injuries to the trachea and esophagus after a secondary injury involving a metal bar. Case Presentation: A 21 years old soldier who suffered from a daily training injury complained of neck ecchymosis with subcutaneous emphysema. The chest CT revealed that paratracheal adipose tissue had moved into the trachea and with massive pneumomediastinum and subcutaneous emphysema. We made a suspected diagnosis of tracheal injury because of the pneumomediastinum. Subsequently, the tracheoscopy revealed a 2-3 cm linear tear of the proximal trachea, with adipose tissue extending into the trachea. Twelve hours after the accident, an emergency surgery was performed. Combined injuries of the trachea plus esophagus were found by accident during the operation. The trachea as well as esophagus was repaired with simple interrupted silk sutures. The patient showed good postoperative recovery and was discharged with no complications.Conclusion: Combined blunt traumatic injuries to the laryngotrachea as well as esophagus are rare. Although uncommon and a diagnostic and management challenge, the illustrated case resulted in excellent outcome.
Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy
Authors: Cakmak Guner , Mantoglu Baris , Gonullu Emre , Ozdemir Kayhan , Kamburoglu Burak 
Published: December 2020

Abstract
Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.
Lifecourse Socioeconomic Changes and Late-Life Cognition in a Cohort of U.S.-born and U.S. Immigrants: Findings from the KHANDLE Study
Authors: Peterson Rachel L. , George Kristen M , Gilsanz Paola , Mayeda Elizabeth Rose , Glymour M. Maria , Meyer Oanh L , Mungas Dan M , DeCarli Charles , Whitmer Rachel A 
Published: December 2020

Abstract
Background: Low socioeconomic status in early and late life has been associated with lower late-life cognition. Less is known about how changes in socioeconomic status from childhood to late life are associated with late-life cognition, especially among diverse populations of older adults.Methods: In a multi-ethnic sample (n=1,353) of older adults, we used linear regression to test associations of change in a comprehensive measures socioeconomic status (financial, cultural, and social domains) from childhood to late life with semantic memory, episodic memory, and executive function. We tested whether the association between SES trajectory and late-life cognition differed by populations who resided in the U.S. during childhood or immigrated to the U.S. as adults.Results: Participants with low childhood/high late life financial capital had better semantic memory (β=0.18; 95% CI: 0.04, 0.32) versus those with low financial capital in both childhood and late life, regardless of childhood residence. We observed a significant interaction in the association of verbal episodic memory and cultural capital by childhood residence (p=0.08). Participants with a foreign childhood residence had higher verbal episodic memory if they had low childhood/high later life cultural capital (β=0.32; 95% CI: 0.01, 0.63), but lower verbal episodic memory if they had high childhood/low late life cultural capital (β=-0.40; 95% CI: -0.94, 0.13). Having high lifecourse social capital was associated with better verbal episodic memory scores among those with a U.S. childhood (β=0.34; 95% CI: 0.14, 0.55), but lower verbal episodic memory among those with a foreign childhood (β=-0.10; 95% CI: -0.51, 0.31).Conclusions: High financial and cultural capital in late life is associated with better cognition, regardless of early childhood SES or childhood residence. Providing increased financial and educational opportunities that contribute to higher late-life SES may produce better cognitive functioning among diverse populations of older adults.
Differential Impact of Mitigation Policies and Socioeconomic Status on COVID-19 Prevalence and Social Distancing in the United States
Authors: Chang Hsien-Yen , Tang Wenze , Hatef Elham , Kitchen Christopher , Weiner Jonathan P. , Kharrazi Hadi 
Published: December 2020

Abstract
BackgroundThe spread of COVID-19 has highlighted the long-standing health inequalities across the U.S. as neighborhoods with fewer resources were associated with higher rates of COVID-19 transmission. Although the stay-at-home order was one of the most effective methods to contain its spread, residents in lower-income neighborhoods faced barriers to practicing social distancing. We aimed to quantify the differential impact of stay-at-home policy on COVID-19 transmission and residents’ mobility across neighborhoods of different levels of socioeconomic disadvantage.MethodsThis was a comparative interrupted time-series analysis at the county level. We included 2,087 counties from 38 states which both implemented and lifted the state-wide stay-at-home order. Every county was assigned to one of four equally-sized groups based on its levels of disadvantage, represented by the Area Deprivation Index. Prevalence of COVID-19 was calculated by dividing the daily number of cumulative confirmed COVID-19 cases by the number of residents from the 2010 Census. We used the Social Distancing Index, derived from the COVID-19 Impact Analysis Platform, to measure the social distancing practice. For the evaluation of implementation, the observation started from Mar 1st 2020 to one day before lifting; and, for lifting, it ranged from one day after implementation to Jul 5th 2020. We calculated a comparative change of daily trends in COVID-19 prevalence and Social Distancing Index between counties with three highest disadvantage levels and those with the least level before and after the implementation and lifting of the stay-at-home order, separately.ResultsOn both stay-at-home implementation and lifting dates, COVID-19 prevalence was much higher among counties with the highest or lowest disadvantage level, while mobility decreased as the disadvantage level increased. Mobility of the most disadvantaged counties was least impacted by stay-at-home implementation and relaxation compared to counties with the most resources; however, disadvantaged counties experienced the largest relative increase in COVID-19 infection after both stay-at-home implementation and relaxation.ConclusionsNeighborhoods with varying levels of socioeconomic disadvantage reacted differently to the implementation and relaxation of COVID-19 mitigation policies. Policymakers should consider investing more resources in disadvantaged counties as the pandemic may not stop until most neighborhoods have it under control.
Donor-dependent Fecal Microbiota Transplantation Efficacy Against Necrotizing Enterocolitis in Preterm Pigs
Authors: Hui Yan , Vestergaard Gisle Alberg , Deng Ling , Kot Witold Piotr , Thymann Thomas , Brunse Anders , Nielsen Dennis Sandris 
Published: December 2020

Abstract
BackgroundFecal microbiota transplantation (FMT) has shown high cure rates against recurrent Clostridioides difficile infection regardless of donor microbiota characteristics, whereas the clinical response of FMT in inflammatory bowel disease appears to be donor-dependent. We recently showed that FMT from healthy suckling piglet donors to newborn preterm piglets decreased the risk of necrotizing enterocolitis (NEC), a serious gastrointestinal disease of preterm infants, but could not replicate this finding in a follow-up study using phenotypically similar donors. This gave us the opportunity to directly investigate the microbiota dynamics of clinically efficient FMT. In this experiment, preterm piglets (n=38) were randomly allocated to receive control saline or FMT from inferior (FMT1) or superior donors (FMT2) by rectal administration. All animals were fed infant formula for four days to induce NEC-like lesions before necropsy and gut pathological evaluation. Donor and recipient colonic microbiotas were analyzed by 16S rRNA gene amplicon sequencing and shotgun metagenomics.ResultsAlthough the two donor microbiotas closely resembled one another, only FMT2 recipients had improved body growth and lower intestinal permeability relative to control, and were protected against NEC. Both FMT groups had shifted colon microbiota composition relative to CON, with increased lactobacilli relative abundance, but FMT2 recipients had a higher lactobacilli abundance relative to FMT1. Limosilactobacillus reuteri and Lactobacillus crispatus strains of FMT recipients showed high phylogenetic similarity with their respective donors, indicating successful engraftment. Further, NEC severity was positively associated with Clostridoides difficile, Clostridium perfringens and Enterococcus faecium abundance, while Lmb. reuteri and Lb. crispatus negatively correlated with diarrhea severity. Genome-resolved analysis indicated a higher gut replication rate of lactobacilli in FMT2 recipients, and identified specific glycosaminoglycan-degrading Bacteroides in the superior donor.ConclusionsFMT efficacy against NEC is donor-dependent, and introduced lactobacilli manifest strain-level differences with respect to colonizing recipients. Using shotgun metagenomics, we traced the engrafted strains back from donors and identified donor-specific microbes of potential importance. This may accelerate our understanding of optimal donor selection for clinical FMT.