bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status
Authors: Mokart Djamel , Darmon Michael , Schellongowski Peter , Pickkers Peter , Soares Marcio , Rello Jordi , Bauer Philippe R. , van de Louw Andry , Lemiale Virginie , Taccone Fabio Silvio , Martin-Loeches Ignacio , Salluh Jorge , Rusinova Katerina , Mehta Sangeeta , Antonelli Massimo , Kouatchet Achille , Barratt-Due Andreas , Valkonen Miia , Landburg Precious Pearl , Bukan Ramin Brandt , Pène Frédéric , Metaxa Victoria , Burghi Gaston , Saillard Colombe , Nielsen Lene B. , Canet Emmanuel , Bisbal Magali , Azoulay Elie ,   for the Efraim investigators and the Nine-I study group
Published: October 2020

Abstract
Background
The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of neutropenia on outcomes of these patients. Secondary objective was to assess etiology of ARF according to neutropenia.

Methods
We performed a post hoc analysis of a prospective multicenter multinational study from 23 ICUs belonging to the Nine-I network. Between November 2015 and July 2016, all adult immunocompromised patients with ARF admitted to the ICU were included in the study. Adjusted analyses included: (1) a hierarchical model with center as random effect; (2) propensity score (PS) matched cohort; and (3) adjusted analysis in the matched cohort.

Results
Overall, 1481 patients were included in this study of which 165 had neutropenia at ICU admission (11%). ARF etiologies distribution was significantly different between neutropenic and non-neutropenic patients, main etiologies being bacterial pneumonia (48% vs 27% in neutropenic and non-neutropenic patients, respectively). Initial oxygenation strategy was standard supplemental oxygen in 755 patients (51%), high-flow nasal oxygen in 165 (11%), non-invasive ventilation in 202 (14%) and invasive mechanical ventilation in 359 (24%). Before adjustment, hospital mortality was significantly higher in neutropenic patients (54% vs 42%; p = 0.006). After adjustment for confounder and center effect, neutropenia was no longer associated with outcome (OR 1.40, 95% CI 0.93–2.11). Similar results were observed after matching (52% vs 46%, respectively; p = 0.35) and after adjustment in the matched cohort (OR 1.04; 95% CI 0.63–1.72).

Conclusion
Neutropenia at ICU admission is not associated with hospital mortality in this cohort of critically ill immunocompromised patients admitted for ARF. In neutropenic patients, main ARF etiologies are bacterial and fungal infections.
Sparse code multiple access on the generalized frequency division multiplexing
Authors: Aquino Guilherme P. , Mendes Luciano L. 
Published: October 2020

AbstractRecent advances in the communication systems culminated in a new class of multiple access schemes, named non-orthogonal multiple access (NOMA), where the main goal is to increase the spectrum efficiency by overlapping data from different users in a single time-frequency resource used by the physical layer. NOMA receivers can resolve the interference among data symbols from different users, increasing the overall system spectrum efficiency without introducing symbol error rate (SER) performance loss, which makes this class of multiple access techniques interesting for future mobile communication systems. This paper analyzes one promising NOMA technique, called sparse code multiple access (SCMA), where C users can share U<C time-frequency resources from the physical layer. Initially, the SCMA and orthogonal frequency division multiplexing (OFDM) integration is considered, defining a benchmark for the overall SER performance for the multiple access technique. Furthermore, this paper proposes the SCMA and generalized frequency division multiplexing (GFDM) integration. Since GFDM is a highly flexible non-orthogonal waveform that can mimic several other waveforms as corner cases, it is an interesting candidate for future wireless communication systems. This paper proposes two approaches for combining SCMA and GFDM. The first one combines a soft equalizer, called block expectation propagation (BEP), and a multi-user detection (MUD) scheme based on the sum-product algorithm (SPA). This approach achieves the best SER performance, but with the significant increment of the complexity at the receiver. In the second approach, BEP is integrated with a simplified MUD, which is an original contribution of this paper, aiming for reducing the receiver’s complexity at the cost of SER performance loss. The solutions proposed in this paper show that SCMA-GFDM can be an interesting solution for future mobile networks.
Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care
Authors: Piccioni Federico , Droghetti Andrea , Bertani Alessandro , Coccia Cecilia , Corcione Antonio , Corsico Angelo Guido , Crisci Roberto , Curcio Carlo , Del Naja Carlo , Feltracco Paolo , Fontana Diego , Gonfiotti Alessandro , Lopez Camillo , Massullo Domenico , Nosotti Mario , Ragazzi Riccardo , Rispoli Marco , Romagnoli Stefano , Scala Raffaele , Scudeller Luigia , Taurchini Marco , Tognella Silvia , Umari Marzia , Valenza Franco , Petrini Flavia ,   on behalf of AIPO, Associazione Italiana Pneumologi Ospedalieri; SIAARTI, Società Italiana di Anestesia Analgesia Rianimazione Terapia Intensiva; SIC, Società Italiana di Chirurgia; SICT, Società Italiana di Chirurgia Toracica; SIET, Società Italiana di Endoscopia Toracica; SIP, Società Italiana di Pneumologia
Published: October 2020

AbstractIntroductionAnesthetic care in patients undergoing thoracic surgery presents specific challenges that require a multidisciplinary approach to management. There remains a need for standardized, evidence-based, continuously updated guidelines for perioperative care in these patients.MethodsA multidisciplinary expert group, the Perioperative Anesthesia in Thoracic Surgery (PACTS) group, was established to develop recommendations for anesthesia practice in patients undergoing elective lung resection for lung cancer. The project addressed three key areas: preoperative patient assessment and preparation, intraoperative management (surgical and anesthesiologic care), and postoperative care and discharge. A series of clinical questions was developed, and literature searches were performed to inform discussions around these areas, leading to the development of 69 recommendations. The quality of evidence and strength of recommendations were graded using the United States Preventive Services Task Force criteria.ResultsRecommendations for intraoperative care focus on airway management, and monitoring of vital signs, hemodynamics, blood gases, neuromuscular blockade, and depth of anesthesia. Recommendations for postoperative care focus on the provision of multimodal analgesia, intensive care unit (ICU) care, and specific measures such as chest drainage, mobilization, noninvasive ventilation, and atrial fibrillation prophylaxis.ConclusionsThese recommendations should help clinicians to improve intraoperative and postoperative management, and thereby achieve better postoperative outcomes in thoracic surgery patients. Further refinement of the recommendations can be anticipated as the literature continues to evolve.
RETRACTED ARTICLE: Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway
Authors: Jia Jia , Kang Xigang , Liu Yanfang , Zhang Jianwei 
Published: October 2020

AbstractEvodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptosis and PI3K/AKT pathway. The results showed that evodiamine exhibits potent antiproliferative effects against two human liver cancer cell lines (HepG2 and PLHC-1) with an IC50 of 20 µM. Nonetheless, the cytotoxic effects of evodiamine were comparatively low against the normal cells as evident from the IC50 of 100 μM. The growth inhibitory effects of evodiamine were found to be due to the induction of apoptosis as revealed by the DAPI, AO/EB and annexin V/PI staining assays. The induction of apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expression in a concentration dependent manner. The wound healing and transwell assay revealed that evodiamine caused a significant decline in the migration and invasion of the HepG2 and PLHC-1 cells. Investigation of the effects of evodiamine on the PI3K/AKT signalling revealed that evodiamine inhibited the phosphorylation of PI3K and AKT proteins. Taken together, the results showed that evodiamine inhibits the growth of human liver cancer via induction of apoptosis and deactivation of PI3K/AKT pathway. The results point towards the therapeutic potential of evodiamine in the treatment of liver cancer.
Treatment of the mandibular shift in an adult woman and the diagnostic value of joint space index: a case report
Authors: Xia Kai , Sun Wentian , Yu Liyuan , Huang Xinqi , Zhao Zhihe , Liu Jun 
Published: October 2020

Abstract
Background
Mandibular deviations are common clinical complaints. The orthodontic or orthognathic treatment of mandibular deviations is tricky because a comprehensive diagnosis, especially a functional one, is difficult to make. A inaccurate diagnosis may lead to a compromised and unstable treatment outcome.

Case presentation
This article describes the diagnosis and treatment of a woman with a mandibular deviation and facial skeletal asymmetry. By eliminating the disharmony of the arch form with elastics and bite turbos, her esthetic and functional outcomes improved. Cone-beam CT (CBCT) and Joint Space Index (JSI) analyses served as the diagnostic approaches and outcome evaluation methods before and after treatment.

Conclusions
A condyle position displacement could be an indication of functional deviation. JSI analysis is a quantitative and convenient choice to compare condyle relative positions.
“Finding my own identity”: a qualitative metasynthesis of adult anorexia nervosa treatment experiences
Authors: Conti Janet E. , Joyce Caroline , Hay Phillipa , Meade Tanya 
Published: October 2020

Abstract
Background
The aim of this metasynthesis was to explore adult anorexia nervosa (AN) treatment experiences, including facilitators and barriers to treatment engagement and ways that questions of identity and personal agency were negotiated in treatment contexts.

Methods
From 14 qualitative studies that met the search criteria, this thematic synthesis analyzed the sensitized concept of identity in the participants’ experiences of AN treatments, including their sense of personal agency, and implications for their recovery. The study was registered with Prospero (ID: CRD42018089259) and is reported according to PRISMA guidelines.

Results
Three meta-themes were generated with the following key findings: grappling with identity, where collaborative and tailored interventions were positively experienced; the quality of the therapeutic relationship, which existed in a recursive relationship; and, rebuilding identity that included therapists standing with the person in recovering a sense of identity outside the anorexic identity. Importantly, interventions that failed to be negotiated with the person were experienced as disempowering however, where a two-way trust existed in the therapeutic relationship, it critically empowered and shaped participants’ sense of identity, and broadened the perception that they were valuable as a person.

Conclusions
There was consensus across the range of treatment contexts that individuals with a lived AN experience preferred treatments where they experienced (1) a sense of personal agency through tailored interventions; and (2) therapists who treated them as a person who, in the face of their struggles, had skills and capacities in the processes of recovering and rebuilding sustainable and preferred identities outside the AN identity.
COV-OBS.x2: 180 years of geomagnetic field evolution from ground-based and satellite observations
Authors: Huder Loïc , Gillet Nicolas , Finlay Christopher C. , Hammer Magnus D. , Tchoungui Hervé 
Published: October 2020

AbstractWe present the geomagnetic field model COV-OBS.x2 that covers the period 1840–2020. It is primarily constrained by observatory series, satellite data, plus older surveys. Over the past two decades, we consider annual differences of 4-monthly means at ground-based stations (since 1996), and virtual observatory series derived from magnetic data of the satellite missions CHAMP (over 2001–2010) and Swarm (since 2013). A priori information is needed to complement the constraints carried by geomagnetic records and solve the ill-posed geomagnetic inverse problem. We use for this purpose temporal cross-covariances associated with auto-regressive stochastic processes of order 2, whose parameters are chosen so as to mimic the temporal power spectral density observed in paleomagnetic and observatory series. We aim this way to obtain as far as possible realistic posterior model uncertainties. These can be used to infer for instance the core dynamics through data assimilation algorithms, or an envelope for short-term magnetic field forecasts. We show that because of the projection onto splines, one needs to inflate the formal model error variances at the most recent epochs, in order to account for unmodeled high frequency core field changes. As a by-product of the core field model, we co-estimate the external magnetospheric dipole evolution on periods longer than 2 years. It is efficiently summarized as the sum of a damped oscillator (of period 10.5 years and decay rate 55 years), plus a short-memory (6 years) damped random walk.
Introduction of a digital near-vision reading test for normal and low vision adults: development and validation
Authors: Labiris Georgios , Panagiotopoulou Eirini-Kanella , Chatzimichael Eleftherios , Tzinava Maria , Mataftsi Asimina , Delibasis Konstantinos 
Published: October 2020

Abstract
Background
MNREAD is an advanced near-vision acuity chart that has already been translated and validated in Greek language. Considering that no validated Greek digital near-vision test exists, our primary objective was to develop and validate a digital near-vision reading test based on the fundamental properties of the Greek printed MNREAD (MNREAD-GR).

Methods
This is a prospective, comparative study. A digital near-vision chart was developed (Democritus Digital Acuity Reading Test – DDART) with text size calibration, audio recording for automatic reading timing, as well as automatic calculation of reading acuity (RA), maximum reading speed (MRS), critical print size (CPS) and reading accessibility index (ACC). Normal and low vision subjects participated in the validation process, responding to MNREAD-GR and DDART at the same day, at a 40 cm viewing distance. Differences in all parameters between the charts were compared with t-test and intraclass correlation coefficients (ICCs). Within 15 days, all participants responded again to DDART in a different set of sentences to assess its test-retest reliability.

Results
One hundred patients (normal vision group - NVG: 70 patients; low vision group - LVG: 30 patients) responded to both reading tests. Non-significant differences were detected for all parameters between DDART and MNREAD-GR except for MRS and ACC that were significantly higher in MNREAD-GR in NVG (p <  0.01). NVG participants demonstrated sufficient ICCs that ranged from 0.854 to 0.963, while LVG demonstrated ICCs for RA, ACC, MRS and CPS equal to 0.986, 0.894, 0.794 and 0.723, respectively. All parameters calculated with DDART demonstrated excellent test-retest reliability (ICCs: 0.903 – 0.956).

Conclusions
The proposed reading test presented comparable validity and repeatability to MNREAD-GR suggesting that it can be used both in normal and low vision Greek patients.

Trial registration
ClinicalTrials.gov, NCT04242836. Registered 24 January 2020 – Retrospectively registered.
Refractory pneumothorax and hemothorax associated with metastatic scalp angiosarcoma
Authors: Isowa Masahide , Tanaka Satona , Nakanobo Ryo , Yamada Yoshito , Date Hiroshi 
Published: October 2020

Abstract
Background
Pulmonary metastasis of scalp angiosarcoma (SA) is a rare, but life-threatening disease, challenging to diagnose and manage. We report two cases of pneumothorax and hemothorax with pathologically proven metastasis of SA in the parietal pleura, which was not predictable from images and difficult to manage.

Patient A
A 73-year-old man with SA underwent chemoradiotherapy and surgical resection for primary skin lesion, was sent to our department to treat right empyema, which was developed during chest tube drainage for pneumothorax. Computed tomography (CT) showed multiple bullous lesions. We performed repetitive video-assisted thoracoscopic surgery (VATS) for the debridement and hemostasis; however, hemothorax was uncontrollable. The repeated cytology of pleural effusion showed no malignancy. We eventually performed fenestration and metastatic SA was pathologically diagnosed by the biopsy of parietal pleura. The patient developed respiratory failure and uncontrolled anemia, which were fatal.

Patient B
A 71-year-old man with SA previously treated with chemoradiotherapy was referred to our department for left pneumothorax. CT showed multiple bullous lesions at apex without any changes at parietal pleura. VATS was performed and the apex bullous lesion with air leakage was resected. The parietal pleura showed several dark-red spots and the biopsy was undertaken. The pathological diagnosis was a metastasis of SA along with visceral pleura and parietal pleura. The patient then developed right pneumothorax and left hemopneumothorax. Bilateral pleurodesis was ineffective and the patient died due to deteriorating general condition.

Conclusions
In patients with a history of SA who develop pneumothorax and hemothorax, metastatic SA to visceral and parietal pleura should be always considered. Surgical biopsy, not cytology, is needed for pathological diagnosis. Lesions in the parietal pleura prior to hemothorax were thoracoscopically observed in one case. Surgeons must recognize that conventional surgical intervention or pleurodesis will have unsatisfactory results.
How the provision of childcare affects attitudes towards maternal employment
Authors: Roth Anja 
Published: October 2020

AbstractDo childcare institutions affect gender norms of individuals? I examine the introduction of childcare services and their impact on voters’ support of policies promoting maternal employment. I address the inherent endogeneity between institutions and attitudes by exploiting regional variation in the regulations and provision of childcare for school children outside of regular school hours. My results show that the expansion of childcare for school children increases voters’ support of policies promoting maternal employment. This indicates a direct effect of local institutions on voters’ attitudes. I additionally show that as public costs of the new facilities increase, support of additional policies promoting maternal employment decreases.
Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs
Authors: Cotero Victoria , Kao Tzu-Jen , Graf John , Ashe Jeffrey , Morton Christine , Chavan Sangeeta S. , Zanos Stavros , Tracey Kevin J. , Puleo Christopher M. 
Published: October 2020

Abstract
Background
Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to activate these reflexes and modulate organ function, giving rise to an emerging class of therapeutics called bioelectronic medicines. Dogma maintains that immune cell migration to and from organs is mediated by inflammatory signals (i.e. cytokines or pathogen associated signaling molecules). However, nerve reflexes that regulate immune function have only recently been elucidated, and stimulation of these reflexes for therapeutic effect has not been fully investigated.

Methods
We utilized both electrical and ultrasound-based nerve stimulation to activate nerve pathways projecting to specific lymph nodes. Tissue and cell analysis of the stimulated lymph node, distal lymph nodes and immune organs is then utilized to measure the stimulation-induced changes in neurotransmitter/neuropeptide concentrations and immune cellularity in each of these sites.

Results and conclusions
In this report, we demonstrate that activation of nerves and stimulated release of neurotransmitters within a local lymph node results in transient retention of immune cells (e.g. lymphocytes and neutrophils) at that location. Furthermore, such stimulation results in transient changes in neurotransmitter concentrations at distal organs of the immune system, spleen and liver, and mobilization of immune cells into the circulation. This report will enable future studies in which stimulation of these long-range nerve connections between lymphatic and immune organs can be applied for clinical purpose, including therapeutic modulation of cellularity during vaccination, active allergic response, or active auto-immune disease.
L-fuzzy pre-proximities, L-fuzzy filters and L-fuzzy grills
Authors: Ramadan A. A. , Usama M. A. , Abd El-Latif A. A. 
Published: October 2020

AbstractThis article gives results on fixed complete lattice L-fuzzy pre-proximities, L-fuzzy grills and L-fuzzy filters. Moreover, we investigate the relations among the L-fuzzy pre-proximities , L-fuzzy grills and L-fuzzy filters. We show that there is a Galois correspondence between the category of separated L-fuzzy grill spaces and that of separated L-fuzzy pre-proximity spaces. We introduced the local function associated with L-fuzzy grill and L-fuzzy topology and studied some of its properties. Finally, we build an L-fuzzy topology for the corresponding L-fuzzy grill by using local function.