bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beverage Type and Hydration Parameters in Older Persons Following a Texture-Modified Diet and Living in Long-term Care Residences
Authors: Serrano Jose CE , Martín-Gari Meritxell , Miranda Jèssica , Cassanye Anna , Badia Mireia , Granado-Serrano Ana Belén 
Published: August 2020

Abstract
Background: Dehydration due to insufficient fluid intake is a common feature in older adults, a situation that is exacerbated in those who follow a texture modified diet. Most studies have been focused on the total amount of fluid intake without taking into consideration hydration capacities from different beverages. This study aimed to evaluate which is the relationship between the intake of different beverage types and their relationship with hydration parameters in older adults. Methods: A prospective observational study in 22 volunteers that followed a texture-modified diet and thickened liquids with a monthly follow-up for 4 months was performed with older people living in long-term care residences. Beverage intake was assessed daily, and hydration parameters were determined at the end of each month. Results: 50% of the volunteers presented an inadequate fluid intake (< 90% of the recommended daily intake of 30 mL/kg of body weight). Gelatine was the preferred hydration drink, providing 54% of the water intake outside the diet, while water and fruit juices constituted approximately 18% of the intake each, and other beverages such as milk and yogurt, the remaining 10%. No correlation was observed between the total amounts of liquids taken during the day with any of the biomarkers of hydration analysed. Contrary, plain water intake inversely correlated with blood levels of sodium (r= -0.25), and Angiotensin-Converting-Enzyme (ACE) activity (r= -0.29); while gelatine directly correlated with haematocrit (r= 0.25). Since different beverages were consumed during the day, cluster analysis was performed to determine patterns of beverage intake. Three patterns of beverage intake were identified, mainly high in plain water, high in gelatine, and mixed beverage intake. The pattern with a higher intake of gelatine, as a source of water, reported the worst parameters of hydration. Similarly, it was observed that a pattern with high plain water intake showed higher levels of fluid intake. Conclusions: It was concluded that besides the focus on total fluid intake, an appropriate selection of beverages is another important criterion that should be taken into consideration for hydration in older people.
Embedding the United Nations Sustainable Development Goals into Systems Analysis – Expanding the Food-Energy-Water Nexus
Authors: Niet Taco , Arianpoo Nastaran , Kuling Kamaria , Wright Andrew S. 
Published: August 2020

Abstract
Background: There have been many studies that consider the nexus interactions between energy systems, land use, water use and climate adaptation and impacts. These studies have filled a gap in the literature to allow for more effective policymaking by considering the trade-offs between land use, energy infrastructure as well as the use of water for agriculture and providing energy services. Though these studies fill a significant gap in the modelling literature, we argue that more work is needed to effectively consider policy trade-offs between the 17 United Nations Sustainable Development Goals (SDGs) to avoid missing important interactions.Results: We examine the 17 SDGs to determine if it should be included in a modelling framework and the challenges of doing so. We show that the nexus of climate, land, energy and water needs to be expanded to consider economic well-being of both individuals and the greater economy, health benefits and impacts, as well as land use in terms of both food production and in terms of sustaining ecological diversity and natural capital. Such an expansion will allow systems models to better address the trade-offs and synergies inherent in the SDGs. Luckily, although there are some challenges with expanding the nexus in this way, we feel the challenges are generally modest and that many model structures can already incorporate many of these factors without significant modification.Finally, we argue that SDGs 16 and 17 cannot be met without open-source models and open data to allow for transparent analysis that can be used and reused with a low cost of entry for modellers from less well off nations.Conclusions: To effectively address the SDGs there is a need to expand the common definition of the nexus of climate, land, energy, and water to include the synergies and trade-offs of health impacts, ecological diversity and the system requirements for human and environmental well-being. In most cases, expanding models to be able to incorporate these factors will be relatively straight forward, but open models and analysis are needed to fully support the SDGs.
A Simple Fask Protocol as an Effective Screening Tool for Patients With Abdominal Distention
Authors: Lien Wan-Ching , Chen Jia-Yu , Wang Pei-Hsiu , Ling Dean-An , Lee An-Fu , Ko Ying-Chih , Hsiao Yu-Tse , Wu Chien-Kai , Chang Wei-Tien , Huang Chien-Hua , Wang Hsiu-Po 
Published: August 2020

Abstract
Background: The retrospective study aimed to investigate the effect of point-of-care ultrasound (PoCUS) by a designated protocol for patients with abdominal distention.Methods: Non-traumatic adult patients with abdominal distention were included at the emergency department (ED) of the National Taiwan University Hospital between July 2015 and July 2017. A sonographic scanning protocol (FASK, the focused assessment with sonography in trauma plus the renal US) was included in the post-graduate year and residency US training. The primary outcome included the diagnostic accuracy of the FASK protocol. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the protocol were calculated that discharge/admission diagnosis was as the standard. The secondary outcomes included ED LOS and the rate of ED discharge using the FASK protocol.Results: A total of 512 patients were included. The accuracy of the FASK protocol was 99.0% (507/512), whatever the level of the performer. The sensitivity, specificity, PPV, and NPV were 99.4% (95% CIs, 98.2-99.9%), 100% (95% CIs, 100%), 99.6% (95% CIs, 98.6-100%), and 99% (95% CIs, 97.7-99.7%), respectively. 397 patients (78%) were discharged with the median LOS of 126 minutes (IQR, 84-236 minutes) after receiving PoCUS and proper management. PoCUS was performed approximately 3 hours earlier than CT (median, 179 minutes; IQR, 90-468 minutes; p<0.0001).Conclusions: A simple FASK protocol could be an effective screening tool for non-critical patients with abdominal distention. Being an adjunct of physical examination and management, PoCUS exhibited characteristics of efficacy, timeliness, and safety.Trial registration: NCT04149041 at ClinicalTrials.gov.
HIV Prevalence Trends and Disparities by Gender and Urban-rural Residence Among Adolescents in Sub-saharan Africa
Authors: Cane Reka Maulide , Melesse Dessalegn , Kayeyi Nkomba , Manu Abubakar , Wado Yohannes Dibaba , Barros Aluisio , Boerma Ties 
Published: August 2020

Abstract
Background

In sub-Saharan Africa HIV transmission is a major challenge in adolescents, especially among girls and those living in urban settings. Major international efforts have aimed at reducing sexual transmission. This analysis aims to assess the trends in HIV prevalence by gender in adolescents, as well as urban-rural disparities.
Methods

HIV prevalence data were obtained for 30 countries with a national survey since 2010 and for 23 countries with one survey circa 2005 and a recent survey circa 2015. Countries were grouped into 2% or higher and lower than 2% HIV prevalence among girls 15–19 years in the first survey. Country medians and average annual rates of changes were used to summarize the trends. Data on HIV incidence at ages 15–24 and prevalence at 5–9 and 10–14 years were reviewed from 11 recent national surveys. Trends in urban-rural disparities in HIV prevalence and selected indicators of sexual and HIV testing behaviours were assessed for females and males 15–24 years, using the same surveys.
Results

HIV prevalence among girls 15–19 years declined in the higher HIV prevalence group from 5.7–2.6% during 2005–2015, corresponding with an average annual rate of reduction of 6.5% per year. Among boys, the median HIV prevalence declined from 2.1–1.2% in the higher prevalence group. Smaller changes were observed in the lower prevalence country group where median HIV prevalence among girls decreased from 0.7–0.4% (average annual rate of reduction 5.9%). Girl – boy differences at 10–14 years were small with a country median HIV of 1.0% and 1.3%, respectively. Urban females and males 15–24 had at least 1.5 times higher HIV prevalence than their rural counterparts, and all experienced similar declines during 2005–2015. Condom use and HIV testing increased among adolescents in both higher and lower prevalence countries, but indicators of sexual activity showed little change over time.
Conclusions

HIV prevalence declined in almost all countries during the last decade, in both urban and rural settings, for both sexes. The urban-rural gap persisted and HIV transmission to girls, but not boys, is still a major challenge in eastern and southern African countries.
The Diagnostic Trap Occurred in Two COVID-19 Cases Combined Pneumocystis Pneumonia in Patient with AIDS
Authors: Guo Wei , Wang Maomao , Ming Fangzhao , Tang Weiming , Liang Ke 
Published: August 2020

Abstract
Background : The limited knowledge on the diagnosis of Coronavirus disease 2019 (COVID-19) at the early stage of the pandemic may lead to misdiagnoses, especially when the nucleic acid inspection cannot meet the mass requirement. This condition is even actual for people who are living with HIV/AIDS (PLWHA), for the latter is vulnerable to variable infections. Case Presentation : In this short communication, we introduced two HIV infected individuals who had PCP but was misdiagnosed as COVID-19 initially, and finally infected with SARS-CoV-2 in hospital in Wuhan, China. Eventually, both patients improved soon after they were switched to the treatment of SMZ/TMP.Conclusions : We suggested that the hospitalized COVID-19 cases should be screened with HIV and other pathogens, to prevent that PLWHA who have PCP from being misdiagnosed as COVID-19.
Prevalence of Bacterial Contamination and Antimicrobial Susceptibility Pattern among Blood and Blood Components collected with and without diverging method at Armed Forces Comprehensive Specialized Hospital, Addis Ababa, Ethiopia
Authors: Tsegaye Wondwossen , Bitew Adane , Gize Addisu 
Published: August 2020

Abstract
Background: Transfusion of bacterial contaminated blood and blood components could be a cause of morbidity and mortality. Understanding the mechanism of blood contamination is important in developing infection control strategy.Methods: A comparative cross-sectional study was done 376 blood and blood components collected with and without diverging method in Armed Forces Comprehensive Specialized Hospital. Then, Culturing of collected blood and blood components were inoculated in broth then subcultured on agar plate. And then, the drugs sensitivity test was done for each isolate. Bivariate analysis and multivariate logistic regression were used to infer association.Results: The overall prevalence of bacterial contamination among blood and blood components were 17 (4.5%). The prevalence of bacterial contamination of blood and blood components collected with the non-diverging and diverging method was 14 (7.4%) and 3 (1.6 %) respectively with P value of 0.05. Staphylococcus epidermidis were the most dominate isolates. Gram positive isolates showed more than 74% sensitive for antibiotics and also became more than 9% resistant. Most gram negative isolates became sensitive but Pseudomonas aeruginosa showed resistant for Gentamicin. 29.4% (n= 5/17) isolated bacteria were multidrug resistant.Conclusion: There was a difference between bacterial contamination in blood and blood components collected between diverging and non-diverging blood collection methods.
Metagenomic Sequencing of Stage 3 Periodontitis Reveals Phenotype-Specific Taxonomic and Functional Features of the Subgingival Microbiome
Authors: Altabtbaei Khaled , Maney Pooja , Ganesan Sukirth M , Dabdoub Shareef M , Nagaraja Haikady N , Kumar Purnima S 
Published: August 2020

Abstract
Background: The search for microbial biomarkers of periodontitis has been hampered by our ability to separate disease-specific associations from those that are common to all forms of periodontitis. Here, we present the first functional characterization of the microbiomes of three common clinical phenotypes of this disease: Localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP) and chronic periodontitis (CP). Methods: We collected subgingival plaque samples from sites with disease of 59 subjects with Stage 3 periodontitis and 25 periodontally healthy individuals and used shotgun metagenomics to characterize the aggregate of bacterial genes. Results: Beta-dispersion metrics demonstrated that no two individuals with disease, especially those with chronic disease, are alike (the Anna Karenina Principle), indicating that microbial modulation therapies will have to incorporate patient-specific parameters for efficacy. We discovered broad patterns of microbial dysbiosis that spanned the three disease phenotypes, as well as disease-specific indicators unique to each phenotype. Genes common to all forms of periodontitis encoded pathways that facilitate life in an oxygen-poor, protein and heme-rich, pro-oxidant environment, and enhance capacity for attachment and biofilm formation, while genes encoding the acetate switch, c-type cytochrome and molybdenum cofactor biosynthesis, iron-sulfur clusters, and formate dehydrogenase were unique to LAP. These can serve as potential biomarkers for molecular identification of clinical phenotypes and clarify the role of the microbiome in disease pathogenesis. We also discovered that clinical phenotypes of disease resolved variance in the microbiome with greater clarity than the newly established grading system. Importantly, we observed that one-third of the metagenome of LAP is unique to this phenotype while GAP shares significant functional and taxonomic features with both LAP and CP, suggesting either attenuation of an aggressive disease or an early-onset chronic disease. Conclusion: Within the limitations of a small sample size and a cross-sectional study design, the distinctive features of the microbiomes associated with LAP and CP strongly persuade us that these are discrete disease entities, while calling into question whether GAP is a separate disease entity, or an artifact induced by cross-sectional study designs.
Awake Prone Positioning Does Not Reduce the Risk of Intubation in COVID-19 Treated with High-Flow Nasal Oxygen Therapy. A Multicenter, Adjusted Cohort Study
Authors: Ferrando Carlos , Mellado-Artigas Ricard , Gea Alfredo , Arruti Egoitz , Aldecoa César , Adalia Ramón , Ramasco Fernando , Monedero Pablo , Maseda Emilio , Tamayo Gonzalo , Hernández-Sanz María L. , Mercadal Jordi , Martín-Grande Ascensión , Kacmarek Robert M. , Villar Jesús , Suárez-Sipmann Fernando 
Published: August 2020

Abstract
Background: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone.Methods: Prospective, multicentre, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June, 2020. Patients were classified as HFNO with or without awake-PP. Logistic models were fitted to predict treatment at baseline using the following variables: age, sex, obesity, non-respiratory sequential organ failure assessment score, APACHE-II, C-reactive protein, days from symptoms onset to HFNO initiation, respiratory rate and peripheral oxyhemoglobin saturation. We compared data on demographics, vital signs, laboratory markers, need for invasive mechanical ventilation, days to intubation, ICU length of stay, and ICU mortality between HFNO patients with and without awake-PP.Results: A total of 1076 patients with COVID-19 ARF were admitted, of which 199 patients received HFNO and were analyzed. Fifty-five (27.6%) were pronated during HFNO; 60 (41%) and 22 (40%) patients from the HFNO and HFNO+awake-PP groups were intubated. The use of awake-PP as an adjunctive therapy to HFNO did not reduce the risk of intubation [RR 0.87 (95%CI: 0.53–1.43), p=0.60]. Patients treated with HFNO+awake-PP showed a trend for delay in intubation compared to HFNO alone [median 1 (interquartile range, IQR 1.0-2.5) vs 2 IQR 1.0-3.0] days, (p=0.055), but awake-PP did not affect 28-day mortality [RR 1.04 (95%CI: 0.40–2.72), p=0.92].Conclusion: In patients with COVID-19 ARF treated with HFNO, the use of awake-PP did not reduce the need for intubation or affect mortality.
Prognosis-Related Autophagy Genes in Female Lung Adenocarcinoma
Authors: Liu Zhongxiang , Tang Haicheng , Jiang Yongqian , Zhan Xiaopeng , Kang Sheng , Zhang Koudong , Lin Li 
Published: August 2020

Abstract
Background: To screen the prognosis-related autophagy genes of female lung adenocarcinoma by the transcriptome data and clinical data from TCGA database.Methods: In this study, Screen meaningful female lung adenocarcinoma differential genes in TCGA, use univariate COX proportional regression model to select genes related to prognosis, and establish the best risk model. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied for carrying out bioinformatics analysis of gene function.Results: The gene expression and clinical data of 260 female lung adenocarcinoma patient samples were downloaded from TCGA. 12 down-regulated genes: NRG3, DLC1, NLRC4, DAPK2, HSPB8, PPP1R15A, FOS, NRG1, PRKCQ, GRID1, MAP1LC3C, GABARAPL1. Up-regulated 15 genes: PARP1, BNIP3, P4HB, ATIC, IKBKE, ITGB4, VMP1, PTK6, EIF4EBP1, GAPDH, ATG9B, ERO1A, TMEM74, CDKN2A, BIRC5. GO and KEGG analysis showed that these genes were significantly associated with autophagy and mitochondria (animals). Multi-factor COX analysis of autophagy-related genes showed that ITGA6, ERO1A, FKBP1A, BAK1, CCR2, FADD, EDEM1, ATG10, ATG4A, DLC1, VAMP7, ST13 were identified as independent prognostic indicators. According to the multivariate COX proportional hazard regression model, there was a significant difference in the survival rate observed between the high-risk group (n=124) and the low-risk group (n=126) during the 10-year follow-up (p<0.05). Univariate COX analysis showed that tumor stage, T, M and N stages, and risk score were all related to the survival rate of female lung adenocarcinoma patients. Multivariate COX analysis found that autophagy-related risk scores were independent predictors, with an AUC value of 0.842. At last, there are autophagy genes differentially expressed among various clinicopathological parameters: ATG4A, BAK1, CCR2, DLC1, ERO1A, FKBP1A, ITGA6.Conclusion: The risk score can be used as an independent prognostic indicator for female patients with lung adenocarcinoma. The autophagy genes ITGA6, ERO1A, FKBP1A, BAK1, CCR2, FADD, EDEM1, ATG10, ATG4A, DLC1, VAMP7, ST13 were identified as prognostic genes in female lung adenocarcinoma, which may be the targets of treatment in the future.
Testing Attitudes, Social Desirability and Behavioral Regulations as Moderators of Implicit-Explicit Exercise Cognition Discrepancies in Iranian Students
Authors: Berry Tanya , Taymoori Parvaneh , Shirzadi Kohestan , Pashaei Tahereh , Bahamani Afshin 
Published: August 2020

Abstract
Background: Although there is interest among regarding implicit-explicit exercise cognition discrepancies, there is mixed evidence regarding what moderates the relationship between implicitly and explicitly measured constructs. This study examined this issue with evaluations of exercise relative to health or appearance in a sample of Iranian adolescents. Methods: Participants were 471 students enrolled in grades 9 to 12 from Kurdistan, Iran, of whom 269 (54.9%) were female. The possible moderators included behavioral regulations, explicit attitudes, and social desirability. All students completed questionnaire measures of physical activity behavior, attitudes, social desieality and behavioral regulation. They also completed two Go/No Go Association tasks to measure implicit evaluations of exercise relative to health and apperarance. Results. Attitude was a significant moderator of discrepancies between implicit evaluations of exercise with health and health motives. Interjected regulation moderated implicit-explicit appearance discrepancies in the health models. Participants with low social desirability and negative implicit appearance scores had the highest appearance motivation. Conclusions: Investigating implicit-explicit discrepancies provides insight into the development of interventions targeting exercise behavior among Iranian adolescents.
Land Use Mix and Physical Activity in Older Adults: A Longitudinal Study Examining Changes in Land Use Mix in Two Dutch Cohorts
Authors: Noordzij J. Mark , Beenackers M.A. , Groeniger J. Oude , Timmermans E.J. , Motoc I. , Huisman M. , Lenthe F.J. van 
Published: August 2020

Abstract
BACKGROUNDWith urbanization and aging increasing in coming decades, societies face the challenge of keeping aging populations active. Land use mix (LUM) has been associated with cycling and walking, but whether changes in LUM relate to changes in cycling/walking is less known. OBJECTIVESOur objective was to study the effect of LUM on cycling/walking in two Dutch aging cohorts using data with 10 years of follow-up. METHODSData from 1,114 respondents from the Longitudinal Aging Study Amsterdam (LASA) and 1,561 respondents from the Health and Living Conditions of the Population of Eindhoven and Surroundings (GLOBE) study were linked to LUM in 1000-meter sausage network buffers at three time-points. Cycling/walking outcomes were harmonized to include average minutes spent cycling/walking per week. Data was pooled and limited to respondents that did not relocate between follow-up waves. Associations between LUM and cycling/walking were estimated using a Random Effects Within-Between (REWB) model that allows for the estimation of both within and between effects. Sensitivity analyses were performed on smaller (500-meter) and larger (1600-meter) buffers. RESULTSWe found evidence of between-individual associations of LUM in 1000-meter buffers and walking (β: 11.10, 95% CI: 0.08 ; 21.12), but no evidence of within-associations in 1000-meter buffers. Sensitivity analyses using 500-meter buffers showed similar between-associations, but negative within-associations (β: -35.67, 95% CI: -68.85 ; -2.49). We did not find evidence of between-individual associations of LUM in any buffer size and cycling, but did find evidence of negative within-associations between LUM in 1600-meter buffers and cycling (β: -7.49, 95% CI: -14.31 ; -0.66). DISCUSSIONOur study found evidence of positive associations between LUM and average walking time, but also some evidence of negative associations between a change in LUM and cycling/walking. LUM appears to be related to cycling/walking, but the effect of changes in LUM on cycling/walking is unclear.