bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrahigh Proton Selectivity by Assembled Cationic Covalent Organic Framework Nanosheets
Authors: Liu Xin , Lin Weibin , Bader Al Mohawes Khozama , Khashab Niveen M. 
Published: December 2024

AbstractIonic covalent organic framework (COF) nanosheets are becoming increasingly attractive as promising two‐dimensional (2D) materials for proton transport due to their ionic functionality and tailor‐made pores. However, most synthetic methods for nanosheets rely on surface‐assisted methods or phase transformation often yielding nanosheets with low aspect ratios. In this study, we present a bottom‐up approach utilizing an oil‐oil‐water triphase system to achieve the large‐scale synthesis of ionic COF nanosheets. The intermediate oil layer in this system modulates the diffusion rate of monomers from the top oil phase into the aqueous phase, enabling in‐plane anisotropic secondary growth from the initial discrete fibrous structure into large and crystalline COF nanosheets. The ionic COF nanosheets exhibit excellent proton permeability while simultaneously excluding other cations by casting into crack‐free membranes, demonstrating efficient HCl extraction from acidic water waste. This strategy for larger‐scale COF nanosheet growth will offer an alternative platform for designing multifunctional COF membranes with applications in sophisticated separation technologies.
Decoupling H2 and O2 Release in Particulate Photocatalytic Overall Water Splitting Using a Reversible O2 Binder
Authors: Liu Dan , Xu Huihui , Shen Jinni , Wang Xun , Qiu Chengwei , Lin Huaxiang , Long Jinlin , Wang Ying , Dai Wenxin , Fang Yuanxing , Yang Yanhui , Wang Xuxu , Fu Xianzhi , Zhang Zizhong 
Published: December 2024

AbstractH2 and O2 evolutions occur simultaneously for conventional particulate photocatalytic overall water splitting (PPOWS), leading to a significant backward reaction and the formation of an explosive H2/O2 gas mixture. This is an issue that must be addressed prior to industrialization of PPOWS. Here, a convenient, cost‐effective, and scalable concept is introduced to uncouple hydrogen and oxygen production for PPOWS. Based on this idea, a three‐component photocatalyst, Co(5 %)‐HPCN/(rGO/Pt), is constructed, consisting of a photoresponsive chip (HPCN), a H2 evolution cocatalyst (rGO/Pt), and a cobalt complex capable of reversibly binding O2 (Co), to achieve the decoupling of PPOWS under alternating UV and visible light irradiations. The asynchronous O2 and H2 evolution strategy have considerable flexibility regarding the photocatalyst structure and light sources suitable for PPOWS.
Enhanced Electrochemiluminescence by Knocking Out Gold Active Sites
Authors: Leka Kottaiveedu Sivakumar Indhu , Bouffier Laurent , Sojic Neso , Senthil Kumar Shanmugam 
Published: December 2024

AbstractElectrochemiluminescence (ECL) of the conventional system of [Ru(bpy)3]2+ luminophore and amine‐based coreactants is particularly inefficient on noble metal electrodes. This is due to the formation of a passivating oxide layer on the metal surface inhibiting the electro‐oxidation of amines like tri‐n‐propylamine (TPrA) coreactant. Herein, we demonstrated the enhancement of ECL emission on gold surface by hydroxyl radicals attack that are chemically generated with Cu‐Fenton reagent. These radicals selectively deactivate the gold active sites and knockout the metal surface asperities that counterintuitively led to an amplification of the ECL emission. Atomic force microscopy shows a massive smoothening of the surface. The electrochemical characterization proves that the involved ECL reaction mechanism switches from direct oxidation to catalytic route, where the kinetics of indirect TPrA oxidation is facilitated on deactivated gold surface. Besides, in situ smoothening of a rough electrode in presence of tandem [Ru(bpy)3]2+/TPrA enables Cu2+ sensing with good reliability and limit of detection. Such atomically smoothened and corrosion‐resistant gold surface readily tuned the ECL reactivity and opened new directions on influence of topography and reactivity on ECL mechanisms, thus will be extremely useful for the future development of ECL imaging strategies and highly sensitive ECL sensors.
Optimizing s–p Orbital Overlap Between Sodium Polysulfides and Single‐Atom Indium Catalyst for Efficient Sulfur Redox Reaction
Authors: Wu Guangxuan , Liu Tongfeng , Lao Zhoujie , Cheng Yihao , Wang Tianshuai , Mao Jing , Zhang Haichang , Liu Enzuo , Shi Chunsheng , Zhou Guangmin , He Chunnian , Hu Wenbin , Zhao Naiqin , Wu Ningning , Chen Biao 
Published: December 2024

AbstractP‐block metal carbon‐supported single‐atom catalysts (C‐SACs) have emerged as a promising candidate for high‐performance room‐temperature sodium‐sulfur (RT Na−S) batteries, due to their high atom utilization and unique electronic structure. However, the ambiguous electronic‐level understanding of Na‐dominant s‐p hybridization between sodium polysulfides (NaPSs) and p‐block C‐SACs limits the precise control of coordination environment tuning and electro‐catalytic activity manipulation. Here, s‐p orbital overlap degree (OOD) between the s orbitals of Na in NaPSs and the p orbitals of p‐block C‐SACs is proposed as a descriptor for sulfur reduction reaction (SRR) and sulfur oxidation reaction (SOR). Compared to NG and NG‐supported InN4 (NG‐InN4) SACs, the nitrogen‐doped graphene‐supported InN5 (NG‐InN5) SACs show the largest s‐p OOD, demonstrating the weakest shuttle effect and the lowest reaction energy barriers in both SRR and SOR. Accordingly, the designed catalysts allow the Na−S pouch batteries to retain a high capacity of 490.7 mAh g−1 at 2 A g−1 with a Coulombic efficiency of 96 % at a low electrolyte/sulfur (E/S) ratio of 4.5 μl mg−1. This work offers an s‐p orbital overlap descriptor describing the interaction between NaPSs and p‐orbital‐dominated catalysts for high‐performance RT Na−S batteries.
Structural and Electrical Characterization of Cs2SnBr6: Insights From Raman Spectroscopy and Conductivity Under Varying Light Conditions
Authors: Bouzidi Mohamed , Alatawi Abdullah A. , Jebnouni Achref , Teka Safa , Osman Sayda , Mohamed Nuzaiha , Soury Raoudha , Bechir Mohamed Ben 
Published: December 2024

ABSTRACTLead‐free tin halide perovskites, particularly Cs2SnBr6, are gaining significant attention for their potential in optoelectronic applications. In this study, we investigate the material's electrical and vibrational properties under varying illumination conditions, providing novel insights into the impact of light on its conduction mechanisms. Cs2SnBr6 was synthesized via liquid‐phase and solid‐state reactions, and we report comprehensive analyses of its impedance, AC conductivity, and dielectric properties over a wide frequency range. Notably, our results reveal that light‐induced photogenerated charge carriers enhance conductivity, which is well explained by the overlapping large‐polaron tunneling (OLPT) model, while in darkness, the material follows the correlated barrier hopping (CBH) model. Moreover, Raman spectroscopy highlights structural changes, including a slight shortening of Sn–Br bond distances under illumination, which influences the vibrational frequencies and intensities. These findings emphasize the crucial role of illumination in tuning the electrical and dielectric responses of Cs2SnBr6, thus demonstrating its considerable promise for future optoelectronic applications, such as solar cells and photodetectors.
Cross‐Phenotype Genome‐Wide Association Study Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis
Authors: Luo Yiming , Khan Atlas , Liu Lili , Lee Cue Hyunkyu , Perreault Gabriel J , Pomenti Sydney F , Gourh Pravitt , Kiryluk Krzysztof , Bernstein Elana J 
Published: December 2024

ObjectiveAn increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross‐phenotype GWAS meta‐analysis.MethodsWe performed cross‐phenotype GWAS meta‐analysis and Bayesian colocalization analysis for SSc and PBC. We performed both genome‐wide and locus‐based analysis, including tissue and pathway enrichment analyses, fine‐mapping, Bayesian colocalization analyses with expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) datasets, and phenome‐wide association studies (PheWAS). Finally, we used an integrative approach to prioritize candidate causal genes from the novel loci.ResultsWe detected a strong genetic correlation between SSc and PBC (rg = 0.84, p = 1.7 x 10‐6). In the cross‐phenotype GWAS meta‐analysis, we identified 44 non‐HLA loci that reached genome‐wide significance (p < 5 x 10‐8). Evidence of shared causal variants between SSc and PBC was found for nine loci, five of which were novel. Integrating multiple sources of evidence, we prioritized CD40, ERAP1, PLD4, SPPL3, and CCDC113 as novel candidate causal genes. The CD40 risk locus colocalized with trans‐pQTLs of multiple plasma proteins involved in B cell function.ConclusionOur study supports a strong shared genetic susceptibility between SSc and PBC. Through cross‐phenotype analyses, we have prioritized several novel candidate causal genes and pathways for these disorders.
Altered category learning and reduced generalization in autistic adults
Authors: Van Overwalle Jaana , Van der Donck Stephanie , Geusens Birte , Boets Bart , Wagemans Johan 
Published: December 2024

AbstractIndividuals with autism spectrum condition (ASC) are suggested to experience difficulties with categorization and generalization. However, empirical studies have mainly focused on one process at a time, and neglected underlying neural mechanisms. Here, we investigated categorization and generalization at a behavioral and neural level in 38 autistic and 38 neurotypical (NT) adults. By presenting shapes sampled from an artificial multidimensional stimulus space, we investigated (1) behavioral and neural underpinnings of category learning and (2) behavioral generalization of trained categorization to both an extended version of the stimulus space and a novel stimulus space. Our previous findings showed that individuals with autism were slower in category learning. In this study, we demonstrate that this slower learning in autism was not related to differences in applied categorization strategy. In contrast, electroencephalography recordings during training did reveal a reduced amplitude of the N1 component in the right occipital temporal cortex after stimulus presentation in autistic participants, which suggests atypical categorical proficiency. In addition, we observed delayed and higher activation in the frontal regions after receiving (negative) feedback in the autistic group, potentially suggesting more explicit feedback processing or a higher salience of prediction errors in autism. Finally, autistic and NT individuals were able to generalize their learned categorization after training. However, when generalizing to a novel set of shapes, autistic individuals were significantly less accurate. Reduced generalization significantly correlated with increased intolerance to uncertainty scores. This multi‐level approach reveals behavioral and neural differences in learning and generalization that could be related to clinical symptoms in autism.
Exploring congenital sucrase‐isomaltase deficiency in autism spectrum disorder patients with irritable bowel syndrome symptoms: A prospective SI gene sequencing study
Authors: Zubarioglu Tanyel , Ulgen Dilara , Akca‐Yesil Sedanur , Akbulut Selin , Onay Huseyin , Uzunyayla‐Inci Gozde , Beser Omer Faruk , Hatemi Ali İbrahim , Aktuğlu‐Zeybek Çiğdem , Kiykim Ertuğrul 
Published: December 2024

AbstractCongenital sucrase‐isomaltase deficiency (CSID) is an inherited metabolic disorder causing chronic gastrointestinal symptoms and malnutrition when untreated. Most CSID patients are likely to remain under‐ or misdiagnosed. This study aimed to investigate prevalence of CSID among patients with autism spectrum disorder (ASD) presenting with irritable bowel syndrome (IBS) symptoms via prospective SI gene sequencing. A prospective cross‐sectional study was conducted on 98 ASD patients exhibiting gastrointestinal symptoms consistent with IBS. Participants were assessed according to Rome IV criteria and underwent SI gene sequencing. Demographic, clinical, and dietary data were collected and analyzed. Sucrose content in various fruits and vegetables was evaluated using three‐day food record, and gastrointestinal symptoms were rated on Likert scale. Seven patients (7%) were diagnosed with CSID based on SI gene analysis, revealing six different variants, including four novel mutations. One patient was homozygous for one variant, and six patients were heterozygous. Clinical presentations predominantly included diarrhea, abdominal pain, and bloating, with two patients showing growth retardation. One patient was diagnosed in adulthood. Food allergy and lactose intolerance were the misdiagnoses prior to CSID diagnosis in two patients. Real prevalence of CSID is likely underestimated. Clinical heterogeneity and non‐specific symptoms contribute to diagnostic challenges. Gastrointestinal symptoms consistent with IBS in ASD patients should include CSID in differential diagnosis. Early genetic screening for SI variants in ASD patients with IBS symptoms can facilitate timely diagnosis and management, improving outcomes. Heterozygous variants of the SI gene should also be considered, as heterozygous patients can exhibit typical CSID symptoms.
Strategie für nachhaltige Planung im Ingenieurbüro Leonhardt, Andrä und Partner
Authors: Nübler Stefan , Mansperger Tobias , Falk Korbinian , Jünger Dorothea 
Published: December 2024

AbstractNachhaltigkeit spielt eine zentrale Rolle im Ingenieurbüro Leonhardt, Andrä und Partner. Die Leitlinien umfassen den Erhalt von Bausubstanz, die Wiederverwendung von Bauteilen, die Nutzung recycelter Baustoffe und die Reduzierung von Baumaterialien. Diese Ansätze werden in verschiedenen Projekten sowohl im Hochbau als auch im Brückenbau erfolgreich umgesetzt. Ein Schwerpunkt liegt auf der Sanierung und Ertüchtigung zur Erhaltung bestehender Bauwerke, um die Lebensdauer zu verlängern und Ressourcen zu schonen. Darüber hinaus werden effiziente Neubauten, bei denen innovative Materialien und Techniken zum Einsatz kommen, realisiert, um den ökologischen Fußabdruck zu minimieren. Hierfür werden Projekte im Hochbau und Brückenbau vorgestellt, bei denen Bauwerke erhalten, Bauteile wiederverwendet oder recycelte Baustoffe eingesetzt wurden, sowie Neubauprojekte, die durch eine reduzierte Materialverwendung, den Einsatz nachhaltiger Materialien und schonender Montagetechnologien überzeugen. Diese Maßnahmen unterstreichen den Anspruch von LAP an nachhaltiges Bauen und zeigen, dass ökonomische Effizienz und ökologische Verantwortung im Ingenieurbau Hand in Hand gehen können.
Will China's Carbon Emission Trading Regulation Really Decrease the Green Investment of Firms? A Microperspective on Corporate Governance
Authors: Li Tingting , Meng Xiangrui , Wang Liukai , Gong Yu 
Published: December 2024

ABSTRACTAlthough China initiated pilot carbon emission trading (CET) regulations in 2014, systematic research specifically examining their impact on corporate green investment expenditure (GIE) and the underlying mechanisms from an internal and external perspective remains limited. To this end, we conducted a quasinatural experiment to investigate how CET regulations affect the GIE of firms in eight high‐emission industries. Using a difference‐in‐differences (DID) approach and propensity score matching (PSM‐DID) on 4117 year‐firm observations of listed A‐share firms located in China's covered areas from 2010 to 2019, we found that CET regulations have a negative impact on firms' GIE. Further, from the microperspective of internal and external mechanisms of corporate governance, we also find negative moderators of corporate innovation capability and carbon trading market efficiency, respectively. The detailed heterogeneity impacts of the CET policy on the GIE of CET‐covered firms in different regions, industries, and ownership types are illustrated. This study systematically analyzes the impact of CET policy on GIE in high‐emission industries in China, focusing on the internal and external mechanisms of corporate governance. By doing so, it contributes to the literature in environmental economics and corporate green investment, offering new insights into the effects of regulatory policies on corporate behavior in high‐emission sectors. Enterprises should properly deal with the relationship between carbon emission quotas and green investment to realize a virtuous cycle of reasonable GIE and carbon emission reduction targets and ultimately achieve a win–win situation for both the economy and the environment.
Synthetic and Pharmacological Activities of Alantolactone and Its Derivatives
Authors: Zhao Jianjun , Zhu Kai , Li Na , Xing Lin , Sheng Ruilong , Shen Yong , Guo Ruihua 
Published: December 2024

ABSTRACTAlantolactone, a sesquiterpene lactone, is isolated from the traditional Chinese medicinal herb Inula helenium L. (Asteraceae). Alantolactone is known as its wide spectrum of biological effects, including antimicrobial, antifungal, antiviral, and anthelmintic activities; anti‐inflammatory activities; and antiproliferative effects on several cancer cell lines. Thus, it has received extensive attention, causing in‐depth research in medicinal chemistry, and numerous undescribed alantolactone derivatives have been synthesized through different strategies. Herein, recent advances in diverse bioactivities and mechanism of alantolactone, including its derivatives, were summarized.
Bilateral Cystic Endosalpingiosis in Cervical Lymph Nodes Mimicking Metastatic Papillary Thyroid Carcinoma Morphologically on Cytology: A Case Report and Literature Review of Diagnostic Challenges
Authors: Davaro Elizabeth , Rohra Prih , Kundu Uma , Gan Qiong 
Published: December 2024

ABSTRACTThe presence of cystic lymph nodes in the neck can present a challenging differential diagnosis, with considerations often including metastatic papillary thyroid carcinoma (PTC), cystic squamous cell carcinoma, and congenital cysts. The cytologic overlap between benign Müllerian inclusions and PTC features adds complexity, especially in unusual locations. A 45‐year‐old woman with a history of ovarian serous borderline tumor (SBT) and non‐invasive Müllerian implants presented with cystic lymphadenopathy in the neck. Imaging revealed multiple suspicious, partially cystic lymph nodes. Fine‐needle aspirations (FNA) from two nodes showed moderate cellularity, monolayered epithelial sheets, and nuclear features suggestive of PTC. FNA cytology, thyroglobulin level, and immunocytochemical profile revealed benign Müllerian cells within lymph nodes. Subsequent histologic evaluation of the excised lymph nodes confirmed cystic endosalpingiosis. This case emphasizes the value of comprehensive clinical‐pathologic correlation and appropriate ancillary studies in the evaluation of cystic lymphadenopathy. Awareness of benign Müllerian inclusions and their mimicry of metastatic disease is essential for accurate diagnosis and optimal patient management.
Handling of the Bivalve Pinna nobilis, Endangered and Pathogen‐Affected Species, for Controlled Reproduction: Precautions Taken
Authors: Ferranti Maria Paola , Azzena Ilenia , Batistini Edoardo , Caracciolo Daniela , Casu Marco , Chiantore Mariachiara , Ciriaco Saul , Firpo Valerio , Intini Luca , Locci Chiara , Montefalcone Monica , Oprandi Alice , Sanna Daria , Scarpa Fabio , Segarich Marco 
Published: December 2024

ABSTRACTFollowing the increased mass mortality of Pinna nobilis populations in the Mediterranean, reliable protocols for the transport, maintenance, and controlled reproduction of this highly endangered species were drawn up within the European Life Pinna project. To test these protocols, the large Pinnidae Atrina fragilis, which shares similar habits to P. nobilis, has been used. In December 2022, a transport trial of nine specimens of A. fragilis from Trieste (NE Italy) to Camogli (NW Italy) was carried out. Two positioning (vertical and horizontal) of the specimens were tested inside the transport box. In the laboratory, after acclimatization, the specimens were placed inside three tanks and fed three times a week with a mix of live microalgae and artificial feed. The transport and maintenance protocols tested on A. fragilis were then applied to 11 P. nobilis collected in the Venice lagoon (NE Italy) and transported to the laboratory in June 2023. Due to the possible infection with Haplosporidium pinnae, considered one of the main etiological agents of mass mortality, P. nobilis individuals were evaluated through molecular analyses during their stay in the tank. Furthermore, these specimens were used as breeders: They spontaneously released already fertilized eggs, as a consequence of transport stress. Rapid larval development stopped at the early veliger stage, and the larvae were fed three times a week with a mixture of microalgae. After the reproduction period, the four specimens that survived 6 months in the laboratory, and constantly tested negative for H. pinnae, were transplanted to the Capo Mortola Marine Protected Area (Liguria, Italy) and monitored monthly.
Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes
Authors: Mao Yuanjie , Gau Jen‐Tzer , Jiang Ning 
Published: December 2024

ABSTRACTAimThe concept of metabolically healthy obesity (MHO) has not been studied in type 1 diabetes (T1D). By analysing datasets from the DCCT/EDIC study, we compared the development of diabetic complications by obesity and metabolic health over 30 years of follow up.Materials and MethodsInsulin resistance was calculated by estimated glucose disposal rate (eGDR). The participants (n = 1127) were then divided into four groups based on time‐weighted mean body mass index and mean eGDR: metabolically healthy non‐obesity (MHN, n = 874), metabolically unhealthy non‐obesity (MUN, n = 66), MHO (n = 146) and metabolically unhealthy obesity (MUO, n = 41). Diabetic complications and cardiovascular events were compared across the four groups.ResultsMUO and MUN groups had significantly higher risk for peripheral neuropathy (p = 0.001 in MUO and p < 0.001 in MUN vs. MHN), cardiac autonomic neuropathy (p < 0.001 in both MUO and MUN vs. MHN), retinopathy (p = 0.001 in MUO and p < 0.001 in MUN vs. MHN) and microalbuminuria (p < 0.001 in both MUO and MUN vs. MHN) than MHN group. Moreover, MUO and MUN groups had significantly higher risks (HR [95%CI]) in any cardiovascular events (2.78 [1.51–5.11] and 1.88 [1.05–3.36]) and major atherosclerotic cardiovascular events (2.72 [1.16–6.37] and 2.31 [1.05–5.10]) compared to MHN group. However, the risk of these complications and cardiovascular events (except peripheral neuropathy and cardiac autonomic neuropathy) in MHO group was not different from that in MHN group.ConclusionsThis study highlights the importance of metabolic health represented by insulin resistance in the development of diabetic complications and cardiovascular events in T1D beyond their weight status.