bluuebunny/crossref_metadata_2025_split huggingface dataset:
Links between climate, drought and minimum wood density in conifers
Authors: Camarero J. Julio , Hevia Andrea 
Published: March 2020

Abstract
As the global climate warms, increased aridity is expected to become a major determinant of forest productivity and tree growth. In gymnosperms, wood density quantified at seasonal to annual scales can be related to changes in tracheid lumen size due to alterations in soil water availability. In this way, minimum wood density (MND) has been shown to respond negatively to early growing-season precipitation in several conifers because dry conditions reduce tracheid lumen size and consequently increase MND. We investigated if this relationship between spring precipitation and MND applies to four conifer species (Abies alba, Pinus sylvestris, Pinus nigra, Juniperus thurifera) in NE Spain from mesic (A. alba, P. sylvestris) to xeric (P. nigra, J. thurifera) conditions. We further assessed how climate, precipitation, and drought-affected tree-ring width (TRW) and MND at several time scales to test if water shortage in spring increases MND and decreases TRW over time and seasonally. Lastly, we quantified the post-drought MND recovery. We found the strongest negative correlations between MND and spring precipitation in P. nigra followed by J. thurifera. In these two species, the associations between MND and 9-month long droughts peaked in early spring (P. nigra, ; J. thurifera, ). Juniperus thurifera presented a better post-drought recovery (decrease in MND), followed by P. nigra and P. sylvestris. We conclude that MND is a reliable and accurate proxy of drought severity during spring in conifers subjected to seasonal water shortage. MND can be used as an early-warning indicator of short- and long-term changes in the responses of trees to water shortage.
Back pain and depressive symptoms: A systematic review and meta-analysis
Authors: Amiri Sohrab , Behnezhad Sepideh , Azad Esfandiar 
Published: March 2020

Background Low back pain is a common disorder that has many consequences. This study is an attempt to meta-analyze the risk of depression symptoms in back pain. Method Four databases were selected for review, and this search was conducted using key words. Eleven eligible articles were selected for review and meta-analysis was conducted. Subgroup analyses were continued with study design and the method of measuring depression. Also, the heterogeneity and publication bias were examined. Results Eleven cohort and cross-sectional articles are used in the meta-analysis between back pain and depressive symptoms. The odds ratio 2.07 was calculated for this relationship. In prospective-cohort studies, 1.71 (95% confidence interval = 1.24–2.36) results indicated that back pain is a risk factor for depression symptoms and in cross-sectional studies, pooled odds ratio (2.33; 95% confidence interval = 1.29–4.21) showed that back pain is associated with depression symptoms. Some degree of publication bias was not found in the study. Conclusions Back pain is an effective factor in increasing the likelihood of depression. Adoption of effective prevention and treatment approaches can play an important role in reducing the psychological consequences in these individuals.
Study of the Stress Distribution Around the Mini-implant During Maxillary Anterior Intrusion Under Different Conditions: A 3-Dimensional Finite Element Analysis
Authors: Thakkar Udita , Patil Neeraj S. , Thakkar Ajay P. , Chitko Shrikant S. , Jaltare Pratik 
Published: March 2020

Introduction: Correction of deep bite is one of the major challenges of orthodontic treatment. Mini-implants provide stable intra-oral anchorage and facilitate the maxillary incisors to be intruded without the usual side. The purpose of this finite element study was to evaluate the stress distribution around the mini-implant during maxillary anterior intrusion under different conditions of different angulations and different positions of implant. Material and Methods: Finite element analysis was carried out. Stress under the following 4 conditions was analyzed: (a) single central implant placed at 90°, (b) single central implant placed at 120°, (c) bilaterally placed implant at 90°, and (d) bilaterally placed implant at 120°. Results: The displacement seen with 90° angulation in the single implant case is less compared with the 120° angulation case for all the 6 maxillary anterior teeth. Also, in the bilateral implant case, the Von Mises stress is less when the 90° angulation case is compared to 120° angulation case. But in bilaterally placed implant, the stress gets distributed evenly in the anterior region. The stress in 90° angulation cases seems to be concentrated at the center. Conclusion: Stresses measured on the teeth are less and distributed more evenly when the point of force application is bilateral. It was also observed that the stress increases with increase in the angulation of the implant. As the contact between the implant and the bone increases, the stability increases. Hence, the implant should be obliquely inserted into the bone. Concentrated stresses are not favorable as they can increase the risk of bone and root resorption.
Partial rupture of anterior cruciate ligament: preliminary experience of selective reconstruction
Authors: Carulli Christian , Innocenti Matteo , Roselli Giuliana , Sirleo Luigi , Matassi Fabrizio , Innocenti Massimo 
Published: March 2020

Abstract
Background
Partial lesions of the anterior cruciate ligament (ACL) are more common than is generally thought, accounting for about 10–12% of ACL injuries. Selective reconstruction may be considered as an option in isolated bundle rupture. The purpose of this study is to evaluate both subjective and objective clinical results, as well as functional recovery time, after selective arthroscopic single-bundle reconstruction in a consecutive series of patients affected by partial ACL rupture.

Materials and methods
Thirty-six patients undergoing selective reconstruction of a single ACL bundle were retrospectively evaluated from a series of 354 ACL reconstructions performed over a 3-year period. Although the suspicion of partial lesions was present at clinical and magnetic resonance imaging (MRI) evaluation, final diagnosis was obtained during arthroscopy. All patients were operated using the same technique and type of fixation, and undergoing the same functional recovery protocol.

Results
Mean follow-up was 64 months (48–84 months). All patients but one achieved good functional recovery and returned to their sports within a mean period of 6.1 months. A single patient complained of postoperative instability 1 year after the index operation and needed further surgery. No complications were recorded.

Conclusions
Selective reconstruction of partial ACL injury is a method to bear in mind because it offers quick functional recovery. Specific technical and diagnostic steps should be performed and discussed with patients preoperatively.

Level of evidence
Level 4, retrospective study.
Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty
Authors: Wu Di , Chen Rui-min , Chen Shao-ke , Liu Ge-li , Chen Lin-qi , Yang Yu , Wang Xin-li , Peng Ya-guang , Gong Chun-xiu 
Published: March 2020

Abstract
Background
To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study.

Methods
A real-world observation was carried out. Children with ISS in seven hospitals in China were enrolled. The height gains standard deviation score and the height gain over the target height were evaluated.

Results
There were 344 ISS patients (217 boys and 127 girls). The baseline average age of boys and girls was 12.7 and 11.7 years, with bone age of 11.7 and 10.1 years, respectively. The baseline height SDS of boys and girls was − 3.07 and − 2.74, and the FAH SDS was − 1.91 and − 1.38, respectively. Compared with the baseline height SDS, the FAH SDS was significantly increased in both boys and girls (both P = 0.0000). The FAH SDS was the highest (gain by 1.54 SD) in the ≥2y treatment course group. Two hundred eighteen patients (218/344, 63.4%) had a FAH SDS > − 2 SD. Among these patients, girls in the 1-2y treatment course group and ≥ 2y group had a FAH SDS higher than TH SDS. Even in the control group, a spontaneous catch-up growth of 1.16 SD was observed. A multivariate linear regression model was used to analyze the results, with FAH SDS as the dependent variable. It was found that the treatment course and baseline height SDS in the boys’ model were statistically significant (P < 0.05), whereas the baseline height SDS and baseline bone age significantly affected the girls’ FAH SDS (P < 0.05).

Conclusions
Both girls and boys of ISS improved FAH by GH therapy even if treatments begin over 10 years old and majority of them reached TH. Some peri-puberty ISS will have a spontaneous height gain. We recommend the course of GH treatment more than 2 years for girls, and longer courses for boys.
Gene expression profiling of progenitor cells isolated from rat rotator cuff musculotendinous junction
Authors: Virk Mandeep S. , Luo Wei , Sikes Katie J. , Li Jun , Plaas Anna , Cole Brian J. 
Published: March 2020

Abstract
Background
Rotator cuff tendon tears are typically degenerative and usually affect the region of tendon insertion on bone. The remnant torn tendon is degenerative and may not be an ideal source for progenitor cells for cell-based therapies. Therefore, the aim of this study was to determine if musculotendinous junction (MTJ), which is adjacent to tendon would be a viable alternate source of progenitor stem cells. We also sought to study the gene expression profile MTJ progenitors and compare it with progenitors isolated from RC tendon, RC muscle and other existing tissue sources (bone marrow, adipose tissue, and Achilles tendon).

Methods
Rotator cuff tendon (RCT), muscle (RCM), and RCMTJ as well as Achilles tendon (AT) tissues were harvested from healthy male Lewis rats and progenitor cultures were established from these tissues and also from bone marrow and adipose tissue. Quantitative RT-PCR was performed on RNA extracts from intact tissues and progenitor cells using a custom array for the mesenchymal stem cell (MSC) differentiation marker genes. The gene expression profile of MSC differentiation markers within four tissues types, six progenitor cells, and between tissue and their corresponding progenitors were compared.

Results
Progenitors cells can be isolated from rat rotator cuff musculotendinous tissue and their pattern of MSC gene expression was similar to the rotator cuff tendon progenitors for majority of the genes tested. However, there were significant differences between the MSC gene expression patterns of RCMTJ and RCM progenitors. Furthermore, there were differences in gene expression between the RCMTJ tissue and its progenitor cells with respect to MSC differentiation markers. The gene expression pattern of RCMTJ tissue was similar to RCM tissue with respect to markers of chondrogenesis, myogenesis, tenogenesis, and MSC specific markers.

Conclusion
We demonstrate that the musculotendinous junction contains distinct set of progenitor cells and their MSC gene expression pattern is similar to rotator cuff tendon progenitors. RCMTJ progenitors will be an attractive option for cell-based regenerative treatment of chronic rotator cuff tears.
Reverse wedge effect following intramedullary nailing of a basicervical trochanteric fracture variant combined with a mechanically compromised greater trochanter
Authors: Zhang Yu , Hu Jun , Li Xiang , Qin Xiaodong 
Published: March 2020

AbstractBackgroundTo introduce an unreported intraoperative complication in intramedullary nailing (IN) of an anatomically reduced trochanteric fracture variant characterized by a basicervical fracture line and coronally disrupted greater trochanter (GT).MethodsA total of 414 trochanteric fractures (TF) treated with intramedullary nails from 2013 to 2017 were included in this study. After analysis of intraoperative fluoroscopy data, 33 cases, including 21 females and 12 males, with a mean age of 72.5 years (33 to 96 years) were identified for internal rotation of the cephalocervical fragment and inferior opening at the basicervical fracture line caused by nailing a satisfactorily reduced TF. The morphological features of this group of patients were analyzed on computed tomography (CT) scan. On radiograph, the magnitude of the displacement and final femoral neck-shaft angle (NSA) were measured.ResultsCT analysis demonstrated that the basicervical fracture line and the posterolateral fragment (PLF) detached from the GT were the two dominant features of this cohort. They were classified according to the number of main fragments: a 3-fragmentary subgroup containing three consistent fragments (cephalocervical fragment, PLF and distal femoral shaft) and a 4-fragmentary subgroup embracing one additional fragment (lesser trochanter). The four subtypes were as follows: the 3-fragmentary S indicating a small PLF (6 cases), the 3-fragmentary M presenting a moderate PLF (3 cases), the 3-fragmentary L standing for the PLF involving whole lesser trochanter (LT) (4 cases) and the 4-fragmentary GL incorporating separated PLF and LT fragments (20 cases). Geological analysis demonstrated that the majority of the basicervical fracture lines (81.8%) just crossed the center of the piriformis fossa, while the others marginally involved the medial wall of the GT. Postoperatively, the mean width of the inferior opening at the basicervical region was 9.2 ± 4.6 mm. The mean NSA was 135.2 ± 7.8 degrees. The comparison between the 3- and 4-fragmentary subgroups revealed no significant differences in magnitude of displacement and NSA.ConclusionThis unreported intraoperative complication predominantly occurred in the intramedullary nailed basicervical trochanteric fracture variant combined with a PLF from the GT. The magnitude of the secondary displacement was substantial and resulted in a relative valgus reduction. This secondary displacement was caused by an impingement of the reamer with the superolateral cortex of the cephalocervical fragment and should be addressed during the operation.Level of evidenceTherapy IV.
A pooled analysis of risk factors of surgically treated leiomyosarcoma of the colon in adults
Authors: Wang Yun , Wang Hao , Yuan Zhi-Lu , Zhao Jing-Fei , Dong Dian-Bo , Gao Qian 
Published: March 2020

Abstract
Background
This current systematic review aimed to evaluate the role of surgical management and risk factors by pooled cases from all identified patients with colonic leiomyosarcomas.

Methods
The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords “colonic,” “colon,” and “leiomyosarcoma.” Risk factors of colonic leiomyosarcoma in the pooled cohort were also evaluated.

Results
Between 1923 and 2019, 41 cases of colonic leiomyosarcoma were identified in 22 (53.7%) males and 19 (46.3%) females, with a mean and median age of 58.7 ± 2.2 years and 56.0 years. According to univariate analysis, smaller tumor size < 8 cm was significantly associated with longer progression-free survival (HR = 6.957, 95% CI 1.405–34.442; p = 0.017), and younger age < 60 years was trending toward better overall survival (HR = 2.765, 95% CI 0.924–8.272; p = 0.069).

Conclusions
Colonic leiomyosarcomas are rare neoplasms with aggressive clinical behaviors. Age < 60 years and tumor size < 8 cm were favorable factors for patients’ better survival.
Functional polymorphisms in FOXC2 gene and Epithelial ovarian Cancer susceptibility in Chinese population
Authors: Zhou Zhijiao , Ou Xiang , Zou Qiong , Chu Ling , Quan Xiyun , Chen Yong , Liu Yang 
Published: March 2020

Abstract
Background
Epithelial ovarian cancer (EOC) is highly lethal gynecological cancer. Forkhead Box Protein C2 (FOXC2) promotes occurrence and development of various malignant tumors. The present study is aimed at exploring the correlation between the polymorphism of FOXC2 and epithelial ovarian cancer susceptibility in Chinese Han population.

Methods
A case-control design was used to verify the association between FOXC2 polymorphisms and epithelial ovarian cancer. The genotyping was performed using Taqman® SNP Genotyping kit by qRT-PCR. The genetic variants including rs3751794 C > T, rs1035550 A > G, rs4843163 C > G and rs4843396 C > T in FOXC2 gene were analyzed. The strength of the associations was detected using odds ratios and 95% confidence intervals. Stratification analyses showed the association between the FOXC2 gene polymorphisms rs3751794 C > T, rs4843163 C > G and rs4843396 C > T with epithelial ovarian cancer susceptibility in terms of age, metastasis status, clinical stage, pathological grade, pregnant times, pausimenia, and the expression of ER, PR, wild p53 and mutant p53.

Results
Rs3751794 C > T (P = 0.0016), rs4843163 C > G (P < 0.0001) and rs4843396 C > T (P < 0.0001) were significantly associated with increased epithelial ovarian cancer risk. In stratification analyses,rs3751794 C > T, was identified to be dominant in no metastasis patients, clinical stage 4 group, middle grade pathological stage, pregnant time over 3 patients, post-menopause women, strong wild type p53 expression; rs4843163 C > G was dominant in high grade clinical stage, high grade pathological stage, post-menopause women, strong ER expression group and no mutant p53 expression group; rs4843396 C > T was dominant in high grade clinical stage, high grade pathological stage, strong ER expression group. The rs1035550 A > G was not related to epithelial ovarian cancer susceptibility.

Conclusions
The results of the current study verified that FOXC2 gene polymorphisms were associated with increased epithelial ovarian cancer risk and suggested that FOXC2 gene polymorphisms might be a potential biomarker for epithelial ovarian cancer susceptibility.
Evaluating TCP performance of routing protocols for traffic exchange in street-parked vehicles based fog computing infrastructure
Authors: Yura Awangku Muhammad Iqbal , Newaz S. H. Shah , Rahman Fatin Hamadah , Au Thien Wan , Lee Gyu Myoung , Um Tai-Won 
Published: March 2020

AbstractAs most vehicles remain parked 95% of its time, this suggests that leveraging the use of On-board Units (OBUs) in parked vehicles would provide communication and computation services to other mobile and fixed nodes for delivery of services such as multimedia streaming, data storage and data processing. The nearby vehicles can form an infrastructure using IEEE 802.11p communication interface, facilitating communication, computation and storage services to the end users. We refer to this as a Vehicular Fog Computing (VFC) infrastructure. In this study, using NS-2 simulator, we investigate how six routing protocols consisting of two proactive routing protocols, Destination Sequence Destination Vector (DSDV) and Fisheye State Routing (FSR); two reactive routing protocols, Ad Hoc On-Demand Distance Vector (AODV) and Dynamic Source Routing (DSR); and two geographic routing protocols, Distance Routing Effect Algorithm for Mobility (DREAM) and Location Aided Routing (LAR) perform when forwarding TCP traffic among the parked vehicles that form a VFC infrastructure in an urban street parking scenario. In order to reflect an urban street parking scenario, we consider a traffic mobility traces that are generated using SUMO in our simulation. To the best of our knowledge, this work is the first effort to understand how vehicle density, vehicle speed and parking duration can influence TCP in an urban street parking scenario when packet forwarding decision is made using proactive, reactive and geographic routing protocols. In our performance evaluation, positive results are observed on the influence of parking duration in parked vehicles as TCP performance in all routing protocols increases with longer parking duration. However, variable speed in parked vehicles and moving vehicles in an urban street parking scenario may not have significant influence on TCP performance, especially in case of reactive and proactive routing protocols. Further, our findings reveal that vehicle density in a VFC infrastructure can noticeably influence TCP performance. Towards the end of the paper, we delineate some important future research issues in order to improve routing performance in a street-parked vehicle based VFC infrastructure.
The improved cortical button shows better breaking strength of sutures compared with 10 original cortical button after cyclic loading
Authors: Takahashi Toshiaki , Takahashi Manabu 
Published: March 2020

Abstract
Background
Suspensory cortical buttons are widely used for fixation of reconstructed ligaments during anterior cruciate ligament (ACL) reconstruction because they have high usability and a favorable fixing force. However, it is not always easy to fix a reconstructed ACL while maintaining appropriate ligament tension. Therefore, we developed an improved cortical button that provides temporary tension until suturing is completed.

Methods
Button holes of our improved EndoButton are not perpendicular to the bone surface on which the button is placed, but have an angle of 45 degrees so that the button can be temporarily fixed by applying tension to the suture. The improved EndoButton and the original EndoButton (Smith & Nephew Inc., Andover, Massachusetts) were each tied to FiberWire 5/7 metric (5 M) (manufactured by Arthrex). Ten cycles of preliminary loading (0–50 N) were applied to each suture, followed by test loading (0–250 N) for 500 or 1000 cycles. Then, a tensile test was performed at a displacement velocity of 20 mm/min.

Results
The breaking strength of the sutures of the improved EndoButton were tend to higher than those of the sutures of the original EndoButton after 1000 loading cycles (p = 0.067, d = 0.883). The moduli of rigidity of the sutures of the improved EndoButton were higher than those of the sutures of the original EndoButton after 500 loading cycles (p = 0.027) and remained almost the same regardless of the number of loading cycles.

Conclusion
We found that compared with the original cortical button, the improved cortical button was better able to retain suture breaking strength and modulus of rigidity, regardless of the number of load cycles.