bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Synthesis of Some Novel Aromatic Amide Derivatives of Nilutamide as In Vitro Anticancer Agents
Authors: Thirukovela Narasimha Swamy , Nukala Satheesh Kumar , Sirassu Narsimha , Manchal Ravinder , Gundepaka Prasad , Paidakula Suresh 
Published: October 2020

AbstractThe synthesis of some new aromatic amide derivatives of Nilutamide (4 a–n) and their structure determination using 1H NMR, 13C NMR and mass spectral analysis was described. The in vitro anti‐cancer activity of the compounds (4 a–n) against several human cancer cell lines like PC3 (prostate), A549 (lung), MCF‐7 (breast) and DU‐145 (prostate) revealed that the compounds 4 c, 4 h, 4 l, 4 m and 4 n have shown greater activity against all the cell lines than the standard Etoposide. Predominantly, the compound 4 n was displayed excellent activity over PC3, A549, MCF‐7 and DU‐145 with IC50 values of 0.14, 0.10, 0.19 and 0.63 μM respectively. Moreover, molecular docking studies of derivatives (4 a–n) on EGFR receptor suggested that the most potent compound 4 n strongly binds to protein EGFR (pdb id : 4HJO). The energy calculations of in silico studies were also in good agreement with the obtained IC50 values.
ROS Responsive Nanoplatform with Two‐Photon AIE Imaging for Atherosclerosis Diagnosis and “Two‐Pronged” Therapy
Authors: Ma Boxuan , Xu Hong , Zhuang Weihua , Wang Yanan , Li Gaocan , Wang Yunbing 
Published: October 2020

AbstractAtherosclerosis, characterized by endothelial injury, progressive inflammation, and lipid deposition, can cause cardiovascular diseases. Although conventional anti‐inflammatory drugs reveal a certain amount of therapeutic effect, more reasonable design on plaque targeting, local anti‐inflammation, and lipid removal are still required for comprehensive atherosclerosis therapy. In this work, a theranostic nanoplatform is developed for atherosclerosis recognition and inhibition. A two‐photon aggregation‐induced emission (AIE) active fluorophore (TP) developed is linked to β‐cyclodextrin (CD) with a ROS responsive bond, which can carry prednisolone (Pred) in its entocoele via supramolecular interaction to build a diagnosis‐therapy compound two‐photon fluorophore‐cyclodextrin/prednisolone complexes (TPCDP). With TPCDP packaged by nanosized micelles based on a ROS sensitive copolymer poly (2‐methylthio ethanol methacrylate)‐poly (2‐methacryloyloxyethyl phosphorylcholine), the TPCDP@PMM can accumulate in atherosclerotic tissue through the damaged vascular endothelium. Activated by the local overexpressed ROS and rich lipid, the micelles are interrupted and TPCDP is further disintegrated with Pred release due to the relatively stronger interaction of lipid with CD, resulting in anti‐inflammatory activity and lipid removal for atherosclerosis inhibition. Besides, labeled with the TP, TPCDP@PMM indicates a distinct two‐photon AIE imaging on atherosclerosis recognition. The “two‐pronged” therapeutic effect and plaque location ability has been confirmed in vivo on ApoE−/− mice, holding TPCDP@PMM a great promise for atherosclerosis theranostics.
Large‐Scale Assembly of Peptide‐Based Hierarchical Nanostructures and Their Antiferroelectric Properties
Authors: Lee Yonghun , Kim Kyung Won , Duong Nguyen Xuan , Park Hyeok , Park Jinhong , Ahn Chang Won , Park In Woo , Jang Seok Cheon , Kim Dong Hoe , Lee Minbaek , Chung Woo‐Jae , Kim Tae Heon , Lee Hyungwoo , Heo Kwang 
Published: October 2020

AbstractAn effective strategy is developed to create peptide‐based hierarchical nanostructures through the meniscus‐driven self‐assembly in a large area and fabricate antiferroelectric devices based on these nanostructures for the first time. The diphenylalanine hierarchical nanostructures (FF‐HNs) are self‐assembled by vertically pulling a substrate from a diphenylalanine (FF) solution dissolved in a miscible solvent under precisely controlled conditions. Owing to the unique structural properties of FF nanostructures, including high crystallinity and α‐helix structures, FF‐HNs possess a net electrical dipole moment, which can be switched in an external electric field. The mass production of antiferroelectric devices based on FF‐HNs can be successfully achieved by means of this biomimetic assembly technique. The devices show an evident antiferroelectric to ferroelectric transition under dark conditions, while the ferroelectricity is found to be tunable by light. Notably, it is discovered that the modulation of antiferroelectric behaviors of FF‐HNs under glutaraldehyde exposure is due to the FF molecules that are transformed into cyclophenylalanine by glutaraldehyde. This work provides a stepping stone toward the mass production of self‐assembled hierarchical nanostructures based on biomolecules as well as the mass fabrication of electronic devices based on biomolecular nanostructures for practical applications.
A secure and collaborative data aggregation scheme for fine‐grained data distribution and management in Internet of Things
Authors: Olakanmi Oladayo Olufemi , Odeyemi Kehinde Oluwasesan 
Published: October 2020

AbstractOne of the greatest threats to the Internet of Things (IoT) is the increase in the number of IoT devices, leading to an exponential increase in the traffics on the communication networks. Asides this, the recent rise in ransomware, which is becoming better at evading detection, is posing security and privacy threats on IoT. With these, there is a need for effective security and aggregation solutions capable of securing data, protecting privacy, and minimizing traffic on the networks. Most of the existing security approaches are network and application‐centric and not effective for IoT due to the heterogeneity and resource constraints of its devices. To address these, we propose a security and aggregation solution, which not only reduces the traffic on the communication network but also enforces integrity and confidentiality on IoT. Our scheme is capable of securing, aggregating, and separating heterogeneous IoT devices' data. Besides, the scheme can detect and filter injected false data during in and out‐of‐network data access through the location‐based parametric‐attribute. Security and performance analysis show that our proposed scheme is secure and efficient.
Taxonomic treatment and phylogenetic analysis of the family Potamogetonaceae in Turkey
Authors: Aykurt Candan , Fehrer Judith , Sarı Yol Duygu , Kaplan Zdenek , Bambasová Veronika , Deniz İ. Gökhan , Aydemir Esra , İmir Nilüfer 
Published: October 2020

AbstractThe family Potamogetonaceae has been taxonomically re‐evaluated in Turkey, employing traditional morphological as well as molecular approaches (rbcL, ITS). Our fieldwork, herbarium studies and molecular analyses proved the existence of 22 taxa, of which 18 belong to Potamogeton (including 4 interspecific hybrids), 3 to Stuckenia and 1 to monotypic Groenlandia. Morphological re‐descriptions of the recognized taxa were prepared, and the information concerning their distribution in Turkey was refined, based on plant material from extensive fieldwork and on specimens stored in herbaria that were previously not examined. Additionally, new identification keys to genera and species, and distribution maps of the species were prepared. Phylogenetic relationships and intraspecific variations were assessed by including samples from other regions. The status of the Zannichelliaceae was investigated using nuclear and chloroplast DNA markers. Our results from ITS sequence divergence corroborate the separation of the two families noted by some authors, and are in accordance with the substantial morphological differences between them. Relatively large genetic distance and non‐monophyly indicate that two genotypes of P. gramineus constitute cryptic species, for which the Turkish localities expand upon the previously known distribution areas. We identified P. schweinfurthii as a new species for Turkey and report P. ×angustifolius for the first time for this country. Weak morphological differentiation and high sequence similarity did not permit reliable differentiation between the closely related Stuckenia amblyphylla and S. filiformis.
Preparing preservice teachers to teach science to english learners: A review
Authors: Rutt Alexis , Mumba Frackson , Kibler Amanda 
Published: October 2020

AbstractDespite growing numbers of English Learners (ELs) in United States science classrooms and recent science education reforms calling for language and literacy integrated science instruction, research is just beginning to address how to prepare preservice teachers (PSTs) to teach science to ELs. Using a framework highlighting key structural and task‐related components for preparing PSTs to teach science to ELs, we systematically examined interventions designed to prepare PSTs to teach in linguistically diverse science classrooms for variations in their structures and tasks for learning, and for outcomes. Results indicate that interventions for preparing PSTs to teach science to ELs ranged from parts of science methods courses to integrated programs spanning both science methods courses and field experiences. Most interventions addressed language and literacy integrated instruction, field experiences, skills for language‐integrated science instruction, and identification and use of students' funds of knowledge in the classroom. Integration of language and literacy into science methods instruction, cohesion across program components, instructor modeling of targeted instructional strategies, and opportunities to practice targeted instructional strategies in K‐12 classrooms were found to be common contributing factors to intervention success. However, the studies highlighted difficulties in PSTs' ability to transfer understanding to instruction and integrate students' funds of knowledge into instruction. Further, other parts of the framework, including asking PSTs to examine their beliefs about learners and science learning in linguistically diverse classrooms and development of PSTs' science content knowledge, were under‐studied. Implications for science teacher preparation, science teaching and learning, and future research are discussed.
A novel two‐stage interval prediction method based on minimal gated memory network for clustered wind power forecasting
Authors: Lang Jianxun , Peng Xiaosheng , Li Wenze , Cai Tao , Gan Zhenhao , Duan Shanxun , Li Chaoshun 
Published: October 2020

AbstractAs the global demand for clean renewable energy has grown, the contribution of wind power in grid systems has significantly improved. Wind power predictions play an important role in the stable and safe operation of grid systems. Considering the shortcomings of traditional wind power point predictions, a novel two‐stage short‐term wind power interval prediction method is proposed in this study. In the proposed method, the minimal gated memory (MGM) network and improved interval width adaptive adjustment strategy, which is an approach that is designed to adjust the prediction interval (PI) labels, are combined for short‐term interval predictions of wind power. First, the point model for subsequence data based on the MGM network is proposed. Subsequently, the interval model is proposed to obtain the final PIs of wind power using the improved interval width adaptive adjustment strategy. Finally, with the purpose of verifying the prediction performance of the proposed model, two datasets and four representative benchmark models are implemented for comparative experiments. The superiority of the proposed model is demonstrated via experimental results, which show that the proposed model can obtain suitable wind power intervals with high confidence and quality.
On a gravity dual to flavored topological quantum mechanics
Authors: Feldman Andrey 
Published: October 2020

Abstract
In this paper, we propose a generalization of the AdS2/CFT1 correspondence constructed by Mezei, Pufu and Wang in [1], which is the duality between 2d Yang-Mills theory with higher derivatives in the AdS2 background, and 1d topological quantum mechanics of two adjoint and two fundamental U(N ) fields, governing certain protected sector of operators in 3d ABJM theory at the Chern-Simons level k = 1. We construct a holographic dual to a flavored generalization of the 1d quantum mechanics considered in [1], which arises as the effective field theory living on the intersection of stacks of N D2-branes and k D6-branes in the Ω-background in Type IIA string theory, and describes the dynamics of the protected sector of operators in $$ \mathcal{N} $$
N
= 4 theory with k fundamental hypermultiplets, having a holographic description as M-theory in the AdS4× S7/ℤk background. We compute the structure constants of the bulk theory gauge group, and construct a map between the observables of the boundary theory and the fields of the bulk theory.
Quasinormal modes in charged fluids at complex momentum
Authors: Jansen Aron , Pantelidou Christiana 
Published: October 2020

Abstract
We investigate the convergence of relativistic hydrodynamics in charged fluids, within the framework of holography. On the one hand, we consider the analyticity properties of the dispersion relations of the hydrodynamic modes on the complex frequency and momentum plane and on the other hand, we perform a perturbative expansion of the dispersion relations in small momenta to a very high order. We see that the locations of the branch points extracted using the first approach are in good quantitative agreement with the radius of convergence extracted perturbatively. We see that for different values of the charge, different types of pole collisions set the radius of convergence. The latter turns out to be finite in the neutral case for all hydrodynamic modes, while it goes to zero at extremality for the shear and sound modes. Furthermore, we also establish the phenomenon of pole-skipping for the Reissner-Nordström black hole, and we find that the value of the momentum for which this phenomenon occurs need not be within the radius of convergence of hydrodynamics.
On the balancing property of Matkowski means
Authors: Kiss Tibor 
Published: October 2020

AbstractLet$$I\subseteq \mathbb {R}$$I⊆Rbe a nonempty open subinterval. We say that a two-variable mean$$M:I\times I\rightarrow \mathbb {R}$$M:I×I→Renjoys thebalancing propertyif, for all$$x,y\in I$$x,y∈I, the equality$$\begin{aligned} {M\big (M(x,M(x,y)),M(M(x,y),y)\big )=M(x,y)} \end{aligned}$$M(M(x,M(x,y)),M(M(x,y),y))=M(x,y)holds. The above equation has been investigated by several authors. The first remarkable step was made by Georg Aumann in 1935. Assuming, among other things, thatMisanalytic, he solved (1) and obtained quasi-arithmetic means as solutions. Then, two years later, he proved that (1) characterizesregularquasi-arithmetic means among Cauchy means, where, the differentiability assumption appears naturally. In 2015, Lucio R. Berrone, investigating a more general equation, having symmetry and strict monotonicity, proved that the general solutions are quasi-arithmetic means, provided that the means in question arecontinuously differentiable. The aim of this paper is to solve (1), without differentiability assumptions in a class of two-variable means, which contains the class ofMatkowski means.
Lazy groupoids
Authors: Kaprinai Balázs , Machida Hajime , Waldhauser Tamás 
Published: October 2020

AbstractA binary operation f(x, y) is said to be lazy if every operation that can be obtained from f by composition is equivalent to f(x, y), f(x, x) or x. We describe lazy operations by identities (i.e., we determine all varieties of lazy groupoids), and we also characterize lazy groupoids up to isomorphism.
Some Inequalities Involving Perimeter and Torsional Rigidity
Authors: Briani Luca , Buttazzo Giuseppe , Prinari Francesca 
Published: October 2020

AbstractWe consider shape functionals of the form $$F_q(\Omega )=P(\Omega )T^q(\Omega )$$

F
q

(
Ω
)

=
P

(
Ω
)

T
q

(
Ω
)

on the class of open sets of prescribed Lebesgue measure. Here $$q>0$$

q
>
0

is fixed, $$P(\Omega )$$

P
(
Ω
)

denotes the perimeter of $$\Omega $$
Ω
and $$T(\Omega )$$

T
(
Ω
)

is the torsional rigidity of $$\Omega $$
Ω
. The minimization and maximization of $$F_q(\Omega )$$

F
q

(
Ω
)

is considered on various classes of admissible domains $$\Omega $$
Ω
: in the class $$\mathcal {A}_{all}$$

A

all

of all domains, in the class $$\mathcal {A}_{convex}$$

A

convex

of convex domains, and in the class $$\mathcal {A}_{thin}$$

A

thin

of thin domains.
Prognostic Impact of Paraaortic Lymph Node Metastasis in Extrahepatic Cholangiocarcinoma
Authors: Nitta Nobuhito , Ohgi Katsuhisa , Sugiura Teiichi , Okamura Yukiyasu , Ito Takaaki , Yamamoto Yusuke , Ashida Ryo , Otsuka Shimpei , Sasaki Keiko , Uesaka Katsuhiko 
Published: October 2020

AbstractBackgroundSurgical resection in patients with extrahepatic cholangiocarcinoma (EHCC) with paraaortic lymph node metastasis (PALNM) remains controversial. The objective of this study was to investigate the prognostic impact of PALNM in resected EHCC.MethodsThe present retrospective study included 410 patients, including 16 patients with PALNM, who underwent surgical resection of EHCC between September 2002 and December 2018. These were compared to 9 patients in whom EHCC was not resected due to PALNM. The clinicopathological features and survival outcomes were investigated to identify the prognostic factors in resected EHCC.ResultsThe overall survival in the resected patients with PALNM was significantly better than that in unresected patients (median survival time [MST] 33.7 vs. 16.7 months, p=0.009) and was not significantly worse than that of patients with regional lymph node metastasis (LNM) (MST 33.7 vs 36.0 months, p=0.278). The multivariate analysis identified age > 70 years, male sex, tumor location (perihilar), residual tumor status, histological grade, microscopic venous invasion, and regional LNM as independent prognostic factors.ConclusionsThere was no significant difference in survival between the resected patients with PALNM and patients with regional LNM, and PALNM was not a significant prognostic factor in the multivariate analysis. Surgical resection may be considered an acceptable approach for EHCC with PALNM in selected patients.
Paclitaxel-Coated Balloon Angioplasty for the Treatment of Infrainguinal Arteries: 24-Month Outcomes in the Full Cohort of BIOLUX P-III Global Registry
Authors: Tepe Gunnar , Zeller Thomas , Moscovic Matej , Corpataux Jean-Marc , Christensen Johnny Kent , Keirse Koen , Nano Giovanni , Schroeder Henrik , Binkert Christoph A. , Brodmann Marianne 
Published: October 2020

Abstract
Purpose
After promising small randomized trials, the aim of BIOLUX P-III was to further investigate the safety and performance of the Passeo-18 lx drug-coated balloon in infrainguinal arteries under real-world conditions.

Methods
BIOLUX P-III is a global prospective single-arm study with follow-up at 6, 12 and 24 months. The primary safety endpoint was freedom from major adverse events (MAE) within 6 months. The primary performance endpoint was freedom from clinically driven target lesion revascularization (TLR) within 12 months.

Results
877 patients/1084 lesions were enrolled. Diabetes mellitus was present in 47.7%, and 42.1% had critical limb ischemia (CLI). The mean lesion length was 89.0 mm with 76.1% of calcified lesions, and 24.9% occluded. At 24 months, freedom from MAE was 83.1% in the full cohort; 84.9% in the femoropopliteal population (592 patients, 691 lesions); 77.7% for long lesions (187 subjects/192 lesions); and 72.5% in the in-stent restenosis (ISR) subgroup (103 subjects/116 lesions). Twenty-four-month freedom from clinically driven TLR was 88.1% in the full cohort; 88.9% in the femoropopliteal population; 80.3% for the long lesions; and 78.4% for ISR. Twenty-four-month all-cause mortality was 12.0% in the full cohort, 10.2% in the femoropopliteal population, 14.8% for the long lesions and 12.0% for ISR. There was no device- or procedure-related death up to 24-month follow-up.

Conclusion
The BIOLUX P-III 24-month outcomes confirm the safety and performance of Passeo-18 lx in infrainguinal arteries in a large population treated under real-world conditions with low complication rates and good clinical outcomes (NCT02276313).
Detection of prostate cancer with 18F-DCFPyL PET/CT compared to final histopathology of radical prostatectomy specimens: is PSMA-targeted biopsy feasible? The DeTeCT trial
Authors: Bodar Y. J. L. , Jansen B. H. E. , van der Voorn J. P. , Zwezerijnen G. J. C. , Meijer D. , Nieuwenhuijzen J. A. , Boellaard R. , Hendrikse N. H. , Hoekstra O. S. , van Moorselaar R. J. A. , Oprea-Lager D. E. , Vis A. N. 
Published: October 2020

Abstract
Purpose
In primary prostate cancer (PCa) patients, accurate staging and histologic grading are crucial to guide treatment decisions. 18F-DCFPyL (PSMA)-PET/CT has been successfully introduced for (re)staging PCa, showing high accuracy to localise PCa in lymph nodes and/or osseous structures. The diagnostic performance of 18F-DCFPyL-PET/CT in localizing primary PCa within the prostate gland was assessed, allowing for PSMA-guided targeted-prostate biopsy.

Methods
Thirty patients with intermediate-/high-risk primary PCa were prospectively enrolled between May 2018 and May 2019 and underwent 18F-DCFPyL-PET/CT prior to robot-assisted radical prostatectomy (RARP). Two experienced and blinded nuclear medicine physicians assessed tumour localisation within the prostate gland on PET/CT, using a 12-segment mapping model of the prostate. The same model was used by a uro-pathologist for the RARP specimens. Based on PET/CT imaging, a potential biopsy recommendation was given per patient, based on the size and PET-intensity of the suspected PCa localisations. The biopsy recommendation was correlated to final histopathology in the RARP specimen. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for clinically significant PCa (csPCa, Gleason score ≥ 3 + 4 = 7) were assessed.

Results
The segments recommended for potential targeted biopsy harboured csPCA in 28/30 patients (93%), and covered the highest Gleason score PCa segment in 26/30 patient (87%). Overall, 122 of 420 segments (29.0%) contained csPCa at final histopathological examination. Sensitivity, specificity, PPV and NPV for csPCa per segment using 18F-DCFPyL-PET/CT were 61.4%, 88.3%, 68.1% and 84.8%, respectively.

Conclusions
When comparing the PCa-localisation on 18F-DCFPyL-PET/CT with the RARP specimens, an accurate per-patient detection (93%) and localisation of csPCa was found. Thus, 18F-DCFPyL-PET/CT potentially allows for accurate PSMA-targeted biopsy.