bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of quercetin water solubility with steviol glucosides and the studies of biological properties
Authors: Nguyen Thi Thanh Hanh , Yu Shin-Hye , Kim Jiyoun , An Eunbae , Hwang Kyeonghwan , Park Jun-Seong , Kim Doman 
Published: December 2019

Background: Quercetin, a flavonol contained in various vegetables and fruits, has various biological activities including anticancer, antiviral, anti-diabetic, and anti-oxidative. However, it has low oral bioavailability due to insolubility in water. Thus, the bioavailability of quercetin administered to human beings in a capsule form, was reported to be less than 1%, with only a small percentage of ingested quercetin getting absorbed in the blood. This leads to certain difficulties in creating highly effective medicinesMethods: Quercetin-rubusoside and quercetin-rebaudioside were prepared. The antioxidant activities of quercetin and Q-rubusoside were evaluated by DPPH radical scavenging method. Inhibition activities of quercetin and Quercetin-rubusoside were determined by measuring the remaining activity of 3CLpro with 200 μM inhibitor. The inhibition activity of quercetin, rubusoside and quercetin-rubusoside were determined by measuring the activity of human maltase which remains at 100 μM rubusoside or quercetin-rubusoside. The mushroom tyrosinase inhibition was assayed with the reaction mixture contained 3.3 mM L-DOPA in 50 mM potassium phosphate buffer (pH 6.8), and 10 U mushroom tyrosinase/ml with or without quercetin or quercetin-rubusoside. Results: With 10% rubusoside treatment, quercetin showed solubility of 7.7 mg/ml in water, and its solubility increased as the concentration of rubusoside increased; the quercetin solubility in water increased to 0.83 mg/mlas rubusoside concentration increased to 1 mg/ml. Quercetin solubilized in rubusoside solution showed DPPH radical-scavenging activity and mushroom tyrosinase inhibition activity, similar to that of quercetin solubilized in dimethyl-sulfoxide. Quercetin-rubusoside also showed 1.2 and 1.9 folds higher inhibition activity against 3CLpro of SARS and human intestinal maltase, respectively, than those of quercetin in DMSO.Conclusions: Quercetin can be solubilized in water with rebaudioside or rubusoside treatment. As Ru concentration increases, the solubility of quercetin in water increases. The solubilization of quercetin in Ru solution did not reduce its biological functions such as the DPPH radical-scavenging and mushroom tyrosinase activity; also, quercetin-rubusoside increased the inhibition activity against the 3CLpro of SARS and human intestinal maltase, when compared with the activity of quercetin in DMSO. Thus, rubusoside and rebaudioside are promising compounds which enhance the solubility of poorly water soluble compounds.Keywords: rubusoside, rebaudioside, flavonol, quercetin, human maltase, 3CLpro
The effect of VMP35 supplement ingredients encapsulated in a novel Phospholipid Prodosome SK713 SLP nutrient delivery technology on properties of live human blood.
Authors: Blum Kenneth , Downs B. William , Kushner Steven , Aloisio Ted , Cronjé Frans J. 
Published: December 2019

Background: In North America digestive malfunction in terms of disintegration, dissolution, and absorption of food and nutrients, is a widespread malady. Malabsorption is also an exacerbating factor in most chronic degenerative diseases that might benefit from dietary supplementation. The purpose of this experiment was to determine, as shown by changes in properties of live blood, whether, a novel soy-lecithin-phospholipid-nutrient encapsulation technology could promote rapid bioavailability and bioactivity of a VMP35 nutraceutical formulation encapsulated within its clustoidal multilamellar Soy Lecithin Phospholipid (SLP) liquid SK713 SLP structures. Method: Changes in peripheral blood smears from 38 subjects were measured utilizing peripheral live blood cell imaging (LBCI) with phase contrast microscopy. Results: Compared to baseline and control, consistently and reproducibly, the SK713 SLP technology effected positive changes in the blood as demonstrated by observable morphological, hematological and rheological changes five minutes from intake and sustained for at least 30 minutes post intake. Conclusions: These results showed that the SK713 SLP system makes an important contribution by increasing the potential benefits of dietary supplementation to those patients with compromised digestive processes. We encourage additional research on this novel delivery system believing that it has potential impact on future therapy. Key Words: digestive malfunction live blood cell imaging, peripheral blood smear, cell aggregation, rheology, phospholipids, nutrient encapsulation, multinutrient complex.
Beneficial effects of a Fermented Papaya Preparation for the treatment of electrohypersensitivity self-reporting patients: results of a phase I-II clinical trial with special reference to cerebral pulsation measurement and oxidative stress analysis
Authors: Irigaray Philippe , Catherine Garrel , Carine Houssay , Pierre Mantello , Dominique Belpomme 
Published: December 2019

Background: Electromagnetic Field Intolerance Syndrome (EMFIS), also termed Idiopathic Environmental Intolerance (IEI) attributed to Electromagnetic Fields (IEI-EMF) by WHO, is a newly identified pathological disorder occurring in electrohypersensitivity (EHS) self-reporting patients. To date, there has been no recognized treatment of this disorder. We have shown that EHS self-reporting patients experience some degree of oxidative stress, inflammation, and autoimmune response. Additionally, Fermented Papaya Preparation (FPP) has some antioxidant, anti-inflammation, and immuno-modulating properties. The objective of this phase I-II clinical trial was thus to test whether FPP treatment is well tolerated, can improve clinical outcomes, and normalize biological abnormalities. Methods: 32 EMFIS-bearing patients were serially included in this trial, among which 26 and 16 of them were evaluable after 3 and 6 months of FPP treatment, respectively. Clinical assessment was conducted during a specific face to face interview by using a validated pre-established questionnaire. Biological assessment consisted of measuring intracerebral tissue pulsometric index (PI) in the temporal lobes with ultrasonic cerebral tomosphygmography (UCTS), in addition to oxidative stress and inflammation with a battery of oxidative stress and inflammation-related peripheral blood tests.Results: Overall clinical improvement was obtained in 50-60% of the cases, among which 20-35% presented major improvement that mainly consisted of the regression of cognitive symptoms such as loss of short term memory, concentration, attention deficiencies, insomnia, and fatigue. This clinical improvement was objectively supported by a statistically significant normal recovery of mean PI in the temporal lobes and by a FPP-related antioxidative effect evidenced by a statistically significant decrease in malondialdehyde levels in the plasma (p<0.0001) and increase in the Glutathione peroxidase activity in red blood cells (p<0.01) in patients experiencing oxidative stress. Moreover, this trial evidenced some degree of FPP-related anti-inflammatory effects by demonstrating a statistically significant decrease in histamine (p=0.049) and HSP27/HSP70 chaperone proteins (p=0.007) in the peripheral blood of patients with initial increased values of these inflammation-related biomarkers.Conclusion: The results suggest a beneficial clinical and biological therapeutic effect of FPP in EHS self-reporting patients. However, the precise underlying mechanism has not yet been elucidated.
Autologous Fat Transfer to Improve Aesthetic Appearance in Facial Asymmetry from Parry-Romberg Syndrome: A Case Report
Authors: Sison Ma. Nina Kristine , Cruz Emmanuel Tadeus , Fernandez Mark Arjan 
Published: December 2019

Objective: To present a case of progressive hemifacial atrophy in a young woman with Parry-Romberg Syndrome and the role of autologous fat transfer to improve her aesthetic appearance and lessen facial asymmetry.
Methods:
Design: Case Report
Setting: Tertiary Government Training Hospital
Patient: One
Results: A 20-year old woman consulted because of drooping of the right eyelid and gradual thinning of right cheek muscles since age 16. On examination, the right facial muscles were hypoplastic with prominent facial bony ridges. An MRI scan showed atrophy of the right medial pterygoid and masseter. She underwent autologous fat transfer on the right side of the face to augment the cheek, improve cosmetic appearance and lessen facial asymmetry.
Conclusion: Our patient is satisfied and happy with the outcome and cosmetic appearance of her autologous fat transfer and is ready to undergo the same procedure if the need arises in the future. Although no definite cure exists for Parry Romberg syndrome, our report illustrates the role of autologous fat transfer as an inexpensive, easily harvested and biocompatible material to improve facial asymmetry. The procedure yielded encouraging results, although long-term benefits remain uncertain.

Keywords: Parry-Romberg syndrome; progressive hemifacial atrophy; autologous transplantation
Peran Keluarga Perhadap Perilaku Gizi Anak Usia Sekolah
Authors: Saifah Andi , Sahar Junaiti , Widyatuti Widyatuti 
Published: November 2019

Nutrition problem is one of the health problems of school-age children which can cause physical, psychological and academic performance to decline. The purpose of this research is to analyze the relationship between the role of the family and the nutritional behavior of school-age children in the working area of ​​the Mabelopura Public Health Center in Palu. The research design was a cross sectional correlation study. The research population was 4944 students of elementary school. The number of samples was 174 students through cluster proportional sampling. Inclusion criteria, namely class of 4,5 and 6, are willing to be respondents and can read and write. The sample selection was done by drawing proportionally with attendance numbers. The research instrument was a weight scale, meter, questionnaire to measure the role of family and nutritional behavior with the validity test r-value between 0.361-0.718 and Cronbach α value> 0.9. Hypothesis testing using the Spearman correlation test, obtained p = 0.035, r = 0.16. The research concludes that there is a positive correlation between the role of family and nutritional behavior of school-age children, it is very important as an example of a good role and the provision in fulfilling balanced nutrition.
WASTE BANK SOCIALIZATION INCREASES COMMUNITY PROSPERITY IN ANGGADITA VILLAGE
Authors: Oktasari Dian Primanita , Sihombing Lukertina , Permana Dudi , Rohman Fatchur 
Published: December 2019

Anggadita Village utilizes the potential of 5,500 m2 of land for fish enlargement and fishing activities. And there are still 5050 m2 of land that has not been utilized. This untapped land will be used to build waste sorting, processing and recycling facilities to make the Citarum River clean and maintained. The area of Anggadita Village is 2.94 Km. Based on situation analysis, efforts should be made to provide alternative solutions that can help clean the Citarum River, sector 18, from Walahar Village to the Emba Bridge Village House and specifically in Sukajaya Village by adding value to the treatment of sorted waste. In addition, activities are needed that can add enthusiasm and skills for all residents and cadres of the Waste Bank to process waste into valuable items, for compost and can also be used as a planting medium for hydroponic plants. Addressing problems that occur in the partner community as described, offers several methods of approach to help solve existing problems by conducting training and counseling methods to produce some economic value products. Implementation of this Partnership Program, the community will be given some training and mentoring activities: waste segregation training, waste management training, managerial and entrepreneurial skills training and Assistance for training participants.
Students’ Perception Toward English Zone In English Study Program of Iain Curup
Authors: Setyowati Maya Sari 
Published: December 2019

The objectives of this research was to know students’ perception toward English Zone at English Study Program of IAIN Curup. The study is a descriptive research presented quantitativelly. The population of this research all students in all semester at English Study Program by using random sampling, total of the student was 37 students. From the population the researcher take students’ from second, fourth, sixth, and eighth semester because they are studying at English Zone. Data were collected through questionnaire. The data were analiyzed by using tabulating and making percentage. There were two indicators, difficulties and benefits of using English in English Zone. The first indicator, from 9 statements got 5 negative perception and 4 positive perception with total 49,48 percentages. Furthermore, the second indicator got 0 negative perception and 7 positive perception with total 50,52 percentages. The result shows that the majority of students’ perception was in positive category toward English Zone. In conclusion students’ perception toward English zone is positive perception to increase their ability in English. However, there are students’ problems using English cause by several factors. There are inhibition, nothing to say, low or uneven participation, and mother tongue use.
KONSELING KELOMPOK MENGGUNAKAN PENDEKATAN COGNITIVE BEHAVIOR THERAPY (CBT) UNTUK MENINGKATKAN KEMATANGAN KARIR
Authors: Jabbar Afan Abdul , Purwanto Deni , Fitriyani Nina , Marjo Happy Karlina , Hanim Wirda 
Published: December 2019

ABSTRAK
Remaja merupakan fase penting dalam masa perkembangan terutama mengenai kemampuan dalam mengambil keputusan-keputusan pilihan karir masa depannya. Keputusan karir akan mudah dicapai apabila peserta didik memiliki kematangan karir yang baik. Konseling kelompok merupakan layanan yang dapat membantu peserta didik mengatasi hambatan dalam kematangan karir. Metode penelitian yang digunakan adalah kajian pustaka yang didukung oleh data-data dari beberapa artikel, buku-buku sumber, dan dokumen pendukung lainnya. Guru bimbingan dan konseling dapat menerapkan layanan konseling kelompok untuk mengatasi masalah-masalah karir. Salah satu pendekatan yang dapat digunakan dalam rangka membantu kematangan karir peserta didik dalam konseling kelompok adalah pendekatan yang berfokus untuk mengubah pikiran negative dan keyakinan maladaptive (CBT) yang dimiliki oleh peserta didik. Hasil penelitian menunjukkan bahwa layanan konseling kelompok dengan pendekatan Cognitive Behavior Theraphy (CBT) secara efektif dapat membantu dalam mengatasi permasalahan karir peserta didik.
Kata Kunci: kematangan karir, konseling kelompok, terapi perilaku kognitif
ABSTRACT
Teenage is an important phase in the developmental period, especially regarding the ability to make decisions about his future career choices. Career decisions will be easily achieved if students have good career maturity. Group counseling is a service that can help students overcome obstacles in career maturity. The research method used is a literature review that is supported by data from several articles, source books, and other supporting documents. Guidance and counseling teachers can apply group counseling services to overcome career problems. One approach that can be used in order to help the career maturity of students in group counseling is an approach that focuses on changing negative thoughts and maladaptive beliefs (CBT) that are owned by students. The results of the study showed that group counseling services with the Cognitive Behavior Theraphy (CBT) approach can be effectively help in solving the career problems of students.
Keyword: career maturity, group counseling, cognitive behavior theraphy
Was Sommerfeld wrong? (To the history of the appearance of spin in relativistic wave equations)
Authors: Petrov S V 
Published: November 2019

Abstract
This article presents a brief history of the appearance of electron spin in relativistic wave equations. Dirac derived his wave equation in 1928 with the intention to obtain an equation for the ‘simplest’ particle with spin zero. But, as Dirac later announced at the European Conference on Particle Physics (Budapest, 4–9 July 1977), it was a big surprise for him that the equation described the states of a particle with spin 1/2.
Geri Çekildi: SAĞLIK DAVRANIŞLARININ DEĞİŞTİRİLMESİNDE TRANSTEORETİK MODEL KULLANIMI
Authors: ÜNVER Zeynep 
Published: December 2019

Sağlık davranış değişikliği sürecini geliştirmek ve en
etkili sağlık davranış değişikliğini elde etmek için günümüzde yaygın olarak
Transteoretik Model (TTM) kullanılmaktadır. Bireyin içinde bulunduğu değişim
aşamasına uygun girişim oluşturan TTM davranış değişimini kolaylaştıran bir
rehber olarak kullanılmaktadır. Transteoretik Model bireyin herhangi bir
davranış değişikliğinin bir anda olmadığını, davranış değişikliğinin
birbirinden farklı aşamaları ve süreçleri içerdiğini kabul eden bilişsel
davranışçı bir modeldir. Bu derlemenin amacı Transteoretik Model kullanımıyla
davranış değişim aşamalarını tanımlayarak, modeli kullanacak araştırmacılara,
hemşirelere ve diğer sağlık çalışanlarına temel bilgi ve davranış değişikliği
gerçekleştirebilmek üzere kaynak sunmaktır.Bu makale 22-02-2021 tarihinde geri çekildi. https://dergipark.org.tr/tr/pub/inonusaglik/issue/60575/894859
Notes on words in early Irish glossaries
Authors: Russell Paul 
Published: December 2019

Note sur trois mots tirés des glossaires irlandais anciens.
1. Analyse de íarus par le préverbe íar suivi d’un pronom suffixé, extrait d’une forme verbale. Conséquences de cette interprétation pour des mots similaires, comme forthus etc.
2. Edition de la version courte de la notice imbas for-osnai, dans le glossaire Dúil Dromma Cetta (DDC) ; l’auteur démontre que c’est la source de la version amplifiée transmise par le Glossaire de Cormac.
3. Examen de la signification de lúathrinde, d’après la notice Coire Brecáin du Glossaire de Cormac, en relation avec les techniques du dessin.
The Theme of Partition in Bapsi Sidhwa's Ice Candy Man
Authors: Ponmalar SK 
Published: December 2019

Bapsi Sidhwa in her novel, Ice CandyMan focuses on the theme of partition of India along with several other themes like the tragic tales of uprooting wonderful dreams of Ranna and Ayah, enormous vacuity of lifeless air that fills the streets of Lahore and the betrayal of human trust. They are all linked with partition phenomenon which left a permanent scar on the memory of India's history. Though everyone seems to be affected by both political and religious horros, very few writers have written about it. Bapsi Sidhwa is one among them. With her artistic vision, she sweeps into a historically significant event of the division of nation.
Students’ Challenges to Speak EFL Skills: A Comparative Study Focused on Selected Private & State Elementary Schools of Wolaita Zone, Ethiopia
Authors: Wodebo Amanuel Yonas 
Published: December 2019

Background: Mastering English speaking skills can not only bring people to be able to communicate with others, but also bring positive impact on students’ academic performance.
Objective:, The main purpose of this comparative study was to investigate into grade 8 students’ challenges of academic performance in EFL speaking skills.
Methods: Each school of the targeted grades had 3 sections which encompassed 50 students. The informants therefore were sampled students and all EFL teachers. Thus, systematic sampling technique was employed to select 24 informants among the whole population of 300 students. Whereas, the EFL teachers, which were 4 in the year 2019 G.C., comprehensibly taken as participants of the study due to their manageable number of the entire population. A mixed research approach was employed via the tools questionnaire, interview and classroom observation. Then, quantitative data were analyzed in percentages; while qualitative were thematically organized and categorized in a form of statement.
Findings: Finally, conclusion and recommendations were drawn based on the findings which were underpinned in particular and common challenges that drew back students’ EFL oral skills in each school. Problems related to curriculum and stakeholders of the school to fulfil every facility were particular challenges affected state school students’ EFL speaking skills. However, problems related to teachers and teaching aids challenged private school students’ EFL speaking efficiencies. Meanwhile, Psychological and social factors commonly affected both of the institution students’ EFL speaking skills.
Conclusion and Recommendations: Therefore, the curriculum should consider EFL programs at first levels (grades 1-4) in all state schools. Besides, stakeholders of state schools should provide audiovisual materials and consider infrastructure. Training should be given for teachers as to how to maneuver audiovisual materials and foster EFL skills. Moreover, parents of the students should stay in touch with the schools’ community following up every performance of their children. On the other hand, private schools’ stakeholders should halt the flux of EFL teachers providing proportional incentives for their effort. Finally, teachers should encourage their students during practice and adapt fraternal approach.
PENGARUH ARUS PENGELASAN TERHADAP KEKUATAN PADA PROSES LAS SMAW MENGGUNAKAN ELEKTRODA TYPE E6013
Authors: Pardi Pardi 
Published: December 2019

Salah satu proses pengelasan yang banyak digunakan dalam kontruksi baja adalah proses SMAW (Shield metal arc welding). Salah satu komponen penentu kualitas sambungan proses ini adalah jenis elektoda. Sementara itu elektroda yang beredar dipasaran biasanya produsen merekomendasikan penggunaan arusnya dalam rentang amper tertentu, sehingga hal tersebut sering membuat welder yang tidak memiliki WPS kesulitan untuk memilih arus yang optimal. Dalam penelitian ini membahas tentang pengaruh besarnya arus pengelasan terhadap kekuatan las SMAW menggunakan Elektroda E6013. Pengelasan dilakukan menggunakan material mild steel ketebalan 8 mm dengan proses pengelasan SMAW tipe mesin las DC dengan variasi arus 50A, 60A, 70A, 80A dan 90A. Jenis sambungan butt joint single V groove, dengan metode pengujian hasil lasan menggunakan visual test. Spesimen dilakukan uji bending untuk melihat hasil kekuatan sambungan las. Berdasarkan hasil pengujian pada jenis elektroda A didapat kekuatan uji bending tertinggi dengan nilai beban patah 12969,31N dilas menggunakan besar arus 90A. Sedangkan pada jenis elektroda B dengan didapat uji bending tertinggi dengan nilai beban patah 23398.83N dilas dengan arus 90A.
SISTEM MONITORING PENGGUNAAN KOMPUTER STUDI KASUS LAB MULTIMEDIA SMK NEGERI 1 MERAUKE
Authors: Sumaryanti Lilik , Loppies Stanly H Dolpies 
Published: November 2019

Pentingnya komputer bagi sekolah yang digunakan untuk melakukan proses pembelajaran siswa- siswi di sekolah. Namum dalam penggunaan komputer di sekolah guru sangat sulit untuk memontiorimg siswa-siswa sehingga perluh di buatkan sebuah sistem untuk melakukan monitoring penggunaan komputer yang ada didalam lab agar guru dapat melihat proses pembelajaran siswa-siswi yang sedang berjalan apakah sudah sesuai dengan instruksi yang diberikan guru dan sistem ini juga dapat melihat dan mengabsen siswa yang masuk pada jam pelajaran praktikum dan proses pembelajran lainya yang menggunkan lab komputer.Pengumpulan data yang dilakuakan pada penelitian ini adalah observasi, wawancara dan dokumentasi yang dikumpulkan yaitu profil sekolah, data guru-guru , data siswa-siswi dan jadwal pembelajaran yang ada di SMK negeri 1 merauke pembuatan sistem monitoring ini menggunakan borland delpi 7 serta menngunakan metode pengujian blackbox dan skenario pengujian dengan bahasa pemograman MySQIL sebagai manajemen pembuatan basis data.Berdasrkan hasil perancangan serta hasil implementasi dan hasil pengujian sistem menggunkan pengujian blackbox bahwa sistem yang dibuat sudah sesuai dengan kebutuhan fungsional pengguna yang diminta oleh karena itu sistem monitoring penggunaan lab multimedia sudah bisa digunakan.