bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development
Authors: Zheng Leliang , Xu Jiaqi , Sai Buqing , Zhu Yinghong , Wang Lujuan , Yin Na , Yu Fenglei , Zhou Wen , Wu Minghua , Tang Jingqun , Xiang Juanjuan 
Published: December 2020

Lung cancer is the most common cancer type around the world. Although major advances in cancer therapy, lung cancer has been the largest proportion of all cancer-related deaths. The respiratory tract contains many types of bacteria and a distinct lung microbiome in lung cancer patients was described in many studies. The specific roles of these lung microorganisms in lung cancer progression remain unclear. In this study, we evaluated the effect of inhalation of bronchoalveolar fluid (BAL) in the lung cancer cell growth. The microbiome-based immune and carcinogenesis was examined in tumor-bearing mouse model. We found that inhalation of BAL collected from non-small cell lung cancer (NSCLC) patients altered the lung microbiota and inhibited tumor cell growth. The inhibitory effect was due to the infiltration of CD3 and CD8+ T cells and decrease of M2 macrophages in lungs. The microbial communities of NSCLC BAL inhalation group were dominated by Pasteurella, whereas the microbial communities of non-cancer control and PBS inhalation group were dominated by Delftia. Linear discriminant analysis (LDA) indicated that the genera Pasteurella, Pseudomonas, and Chryseobacterium were increased in NSCLC BAL inhalation group, while genera Delftia, Ezakiella, Blautia, Cloacibacterium, and Microvirga et al. were increased in PBS and Non-cancer group. We demonstrated a significant positive correlation between Pasteurella and cytotoxic CD8+ TIL and a negative correlation with M2 macrophages. Coriobacteriaceae was positively correlated with M2 macrophages and negatively correlated with CD8+ cells. The abundance of Pasteurella was negatively correlated with tumor cell growth. Our findings provide a promising strategy that can be used as a therapeutic vaccine for lung cancer patients.
Drug Safety of Benzodiazepines in Asian Patients With Chronic Obstructive Pulmonary Disease
Authors: Liao Yi-Hsiang , Chen Liang-Yu , Liao Kuang-Ming , Chen Chung-Yu 
Published: December 2020

Purpose:Many comorbidities, including depression, anxiety, and insomnia, occur in patients with chronic obstructive pulmonary disease (COPD). These patients may be prescribed benzodiazepines (BZDs). However, there are some concerns that benzodiazepines increase the risk of drug overdose, hypercapnic respiratory failure, acute exacerbation and increased mortality. The aim of our study was to evaluate the drug safety of BZDs in patients with COPD.Methods:We used the National Health Insurance Research database in Taiwan from 2002 to 2016 to perform a retrospective cohort study. We enrolled patients who were exposed to the first prescription of BZDs, non-BZDs or a combination (mix user) after COPD diagnosis. We performed 1:1:1 propensity score matching in three groups. The outcomes were COPD with acute exacerbation and all-cause mortality. Poisson regression analysis was performed to evaluate the incidence rate ratios for the outcomes in the groups.Results:After propensity score matching, there were 2,856 patients in each group. After adjusting for confounding factors, we found that compared to BZD users, non-BZD and mix users had nonsignificant differences in outpatient management of acute exacerbations, hospitalization management of acute exacerbations, emergency department management of acute exacerbations and all-cause mortality. BZD and mix groups showed significantly increased admission for acute exacerbation of COPD compared with that of the nonuser group, with IRRs of 2.52 (95% CI, 1.52–4.18;p= 0.0004) and 2.63 (95% CI, 1.57–4.40;p= 0.0002), respectively.Conclusion:BZD, non-BZD, and mix users showed increased COPD-related respiratory events compared to nonusers in Asian subjects.
Complementary Chinese Herbal Medicine Therapy Improves Survival in Patients With Pemphigus: A Retrospective Study From a Taiwan-Based Registry
Authors: Wu Po-Yuan , Li Te-Mao , Chen Shu-I. , Chen Chao-Jung , Chiou Jian-Shiun , Lin Ming-Kuem , Tsai Fuu-Jen , Wu Yang-Chang , Lin Ting-Hsu , Liao Chiu-Chu , Huang Shao-Mei , Lin Yu-Ning , Liang Wen-Miin , Lin Ying-Ju 
Published: December 2020

Pemphigus is a life-threatening and skin-specific inflammatory autoimmune disease, characterized by intraepidermal blistering between the mucous membranes and skin. Chinese herbal medicine (CHM) has been used as an adjunct therapy for treating many diseases, including pemphigus. However, there are still limited studies in effects of CHM treatment in pemphigus, especially in Taiwan. To more comprehensively explore the effect of long-term CHM treatment on the overall mortality of pemphigus patients, we performed a retrospective analysis of 1,037 pemphigus patients identified from the Registry for Catastrophic Illness Patients database in Taiwan. Among them, 229 and 177 patients were defined as CHM users and non-users, respectively. CHM users were young, predominantly female, and had a lesser Charlson comorbidity index (CCI) than non-CHM users. After adjusting for age, sex, prednisolone use, and CCI, CHM users had a lower overall mortality risk than non-CHM users (multivariate model: hazard ratio (HR): 0.422, 95% confidence interval (CI): 0.242–0.735, p = 0.0023). The cumulative incidence of overall survival was significantly higher in CHM users than in non-users (p = 0.0025, log rank test). Association rule mining and network analysis showed that there was one main CHM cluster with Qi–Ju–Di–Huang–Wan (QJDHW), Dan–Shen (DanS; Radix Salviae miltiorrhizae; Salvia miltiorrhiza Bunge), Jia–Wei–Xiao–Yao-–San (JWXYS), Huang–Lian (HL; Rhizoma coptidis; Coptis chinensis Franch.), and Di–Gu–Pi (DGP; Cortex lycii; Lycium barbarum L.), while the second CHM cluster included Jin–Yin–Hua (JYH; Flos lonicerae; Lonicera hypoglauca Miq.) and Lian–Qiao (LQ; Fructus forsythiae; Forsythia suspensa (Thunb.) Vahl). In Taiwan, CHMs used as an adjunctive therapy reduced the overall mortality to approximately 20% among pemphigus patients after a follow-up of more than 6 years. A comprehensive CHM list may be useful in future clinical trials and further scientific investigations to improve the overall survival in these patients.
COVID-19 Antibodies and Outcomes among Outpatient Maintenance Hemodialysis Patients
Authors: Khatri Minesh , Islam Shahidul , Dutka Paula , Carson John , Drakakis James , Imbriano Louis , Jawaid Imran , Mehta Tapan , Miyawaki Nobuyuki , Wu Elain , Yang Stephen , Ali Nicole , Divers Jasmin , Grant Candace , Masani Naveed 
Published: December 2020

Background
Patients on maintenance hemodialysis are particularly vulnerable to infection and hospitalization from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to immunocompromised patients and the clustering that occurs in outpatient dialysis units, the seroprevalence of COVID-19 antibodies in this population is unknown and has significant implications for public health. Also, little is known about their risk factors for hospitalization.

Methods
Three outpatient maintenance hemodialysis units affiliated with a major teaching hospital in the New York area were studied. We determined rates of SARS-CoV-2 positivity via nasopharyngeal, real-time, reverse-transcriptase PCR (RT-PCR); SARS-CoV-2 IgG seropositivity; hospitalization; and mortality.

Results
Of 367 patients, 28% had either SARS-CoV-2 seropositivity or PCR positivity. Prevalence across the three respective units was 7%, 32%, and 70%. Those who were either antibody or PCR positive were significantly younger (65 versus 69 years, P=0.05), and had a higher prevalence of Black race (43% versus 30%, P=0.001) and Hispanic ethnicity (32% versus 12%, P<0.001) compared with those who tested negative. Higher positivity rates were also observed among those who took taxis and ambulettes to and from dialysis, compared with those who used personal transportation. Antibodies were detected in all of the patients with a positive PCR result who underwent serologic testing. Of those that were seropositive, 32% were asymptomatic. The hospitalization rate on the basis of either antibody or PCR positivity was 35%, with a hospital mortality rate of 33%. Aside from COPD, no other variables were more prevalent in patients who were hospitalized.

Conclusions
We observed significant differences in rates of COVID-19 infection within three outpatient dialysis units, with universal seroconversion. Among patients with ESKD, rates of asymptomatic infection appear to be high, as do hospitalization and mortality rates.
La Calota de Ameghino:
Authors: Schávelzon Daniel 
Published: December 2020

Se ha publicado el fechado de Carbono 14 de un fragmento de cráneo estudiado por Florentino Ameghino a finales del siglo XIX. A Ameghino le sirvió para afirmar su teoría sobre el origen del hombre en las pampas al que le otorgaba un millón de años y el ser parte fundamental de la cadena del origen de la humanidad. Hubo polémicas, pero el tema quedó cerrado cuando Ales Hrdlicka y Bailey Willis en 1912 demostraron que estaba basado malas interpretaciones. El cráneo había llegado a un nivel geológico discutible y por causas no naturales.El hallazgo había sido hecho en un sitio que hasta poco antes estaba dentro del agua del Río de la Plata, cerca de 400 metros de la orilla antigua, lo que ayudaba al antiguo fechamiento. Al ubicarlo ahora en una fecha hacia 1720 dC resulta interesante construir hipótesis sobre su presencia allí (Politis y Bonomo 2011), en lo que hubo en el lugar y en las condiciones en que fue encontrado; es decir su contexto. Los datos de otros hallazgos frente a Buenos Aires ayudan a repensar el tema, y la revisión cartográfica y documental permite entender que afirmaciones hechas tanto por un bando como otro no tomaron en cuenta los eventos de alteración del sitio.
Indigenous Cultural Heritage: Developing New Approaches and Best Practices for World Heritage Based on Indigenous Perspectives and Values
Authors: Archibald Diane 
Published: December 2020

In support of advancing the recognition and inclusion of Indigenous Cultural Heritage in all its diverse forms within the UNESCO World Heritage Convention and World Heritage Site designations, this paper documents and discusses the presentations, Indigenous-led Forum, and recommendations and outcomes of the International Conference on Indigenous Cultural Heritage organized by the ICOMOS International Scientific Committee on Theory and Philosophy of Restoration and Conservation in partnership with the First Nations House of Learning, University of British Columbia, Vancouver, Canada, in November 2019.
Reviews of low-temperature atmospheric pressure plasma for studying hemostasis and international standardization
Authors: Sakakita Hajime , Shimizu Tetsuji , Ikehara Yuzuru 
Published: December 2020

Abstract
Using current surgical hemostasis technologies, the scarring that results from cauterization limits the efficacy of surgery; therefore, a method that controls bleeding without scarring tissue is required. In this regard, low-temperature atmospheric pressure plasma (LTP) has been studied as a minimally invasive technology. There are several reports regarding induced platelet aggregation, fibrin polymerization, hemolytic coagulation of red blood cells, and serum protein aggregation following LTP treatment of the blood. However, details of the interrelationships between “plasma quality such as oxygen radicals and electric properties” and “coagulation and aggregation” are not fully understood. It is important to clarify the differences between plasma qualities by analysis. However, in the case of protein aggregation, electric effects may be a key factor. Conversely, LTP devices manufactured for hemostasis are subject to a new international standard (IEC 60601-2-76), which provides basic safety and essential performance specifications.
In situ observations of the transition between beryl and phenakite in aqueous solutions using a hydrothermal diamond-anvil cell
Authors: Wang Xian , Li Jiankang 
Published: December 2020

ABSTRACT
Beryl and phenakite are important industrial beryllium minerals. In the hydrous melt of the BeO–Al2O3–SiO2–H2O (BASH) system, experiments using quench-type high-temperature and high-pressure equipment have revealed that the different activities of Al2O3 and SiO2 (αAl2O3 and αSiO2) are the main factors that lead to different beryllium mineral assemblages. In this study, we attempted in situ observation of the crystallization process of phenakite and beryl in an aqueous solution of the BASH system using a hydrothermal diamond-anvil cell. Experimental results indicate that phenakite and beryl can crystallize faster in this regime (i.e., 2.93–0.58 × 10−5 cm/s in length and 22.39–3.23 μm3/s in volume) than from a hydrous melt. In addition, in the phenakite and beryl crystallization, pressure–temperature conditions were greater than 467 °C and 220 MPa and 495 °C and 221 MPa, respectively, and their upper temperatures and pressures attained 845–870 °C and 500–1300 MPa. These features indicate that temperature is not the main factor that controls the stability of phenakite and beryl in the BASH system. This stability can be attributed to the diffusion of components in aqueous solution that change αSiO2 and αAl2O3 during the heating and cooling processes. During heating, αSiO2 increases while beryl is dissolving, which leads to phenakite crystallization; during cooling, αSiO2 and αAl2O3 are sufficient for the remaining beryl to recrystallize. Therefore, the transition between phenakite and beryl in the aqueous solution in the BASH system may be different during heating and cooling processes. This reasoning can explain the abundance of phenakite in miarolitic cavities and the occurrence of phenakite, rather than beryl, in hydrothermally altered pegmatites, volcanic rocks, and other beryllium-rich rocks.
An online headphone screening test based on dichotic pitch
Authors: Milne Alice E. , Bianco Roberta , Poole Katarina C. , Zhao Sijia , Oxenham Andrew J. , Billig Alexander J. , Chait Maria 
Published: December 2020

AbstractOnline experimental platforms can be used as an alternative to, or complement, lab-based research. However, when conducting auditory experiments via online methods, the researcher has limited control over the participants’ listening environment. We offer a new method to probe one aspect of that environment, headphone use. Headphones not only provide better control of sound presentation but can also “shield” the listener from background noise. Here we present a rapid (< 3 min) headphone screening test based on Huggins Pitch (HP), a perceptual phenomenon that can only be detected when stimuli are presented dichotically. We validate this test using a cohort of “Trusted” online participants who completed the test using both headphones and loudspeakers. The same participants were also used to test an existing headphone test (AP test; Woods et al., 2017, Attention Perception Psychophysics). We demonstrate that compared to the AP test, the HP test has a higher selectivity for headphone users, rendering it as a compelling alternative to existing methods. Overall, the new HP test correctly detects 80% of headphone users and has a false-positive rate of 20%. Moreover, we demonstrate that combining the HP test with an additional test–either the AP test or an alternative based on a beat test (BT)–can lower the false-positive rate to ~ 7%. This should be useful in situations where headphone use is particularly critical (e.g., dichotic or spatial manipulations). Code for implementing the new tests is publicly available in JavaScript and through Gorilla (gorilla.sc).
Wirbelfrakturen nach Absetzen von Denosumab
Authors: Gysling Etzel 
Published: December 2020

Wird Denosumab (Prolia®, Xgeva®) abgesetzt oder stark verspätet verabreicht, kann es zu gehäuften Wirbelfrakturen kommen. Es ist nicht sicher, dass sich dies durch eine sofortige Gabe von Bisphosphonaten vermeiden lässt. Deshalb müssen Pro und Kontra vor einer Therapie mit Denosumab genau geprüft werden.
Herzrhythmusstörungen unter Ginkgo
Authors: Gysling Etzel 
Published: December 2020

Nur ein Teil der in der Nebenwirkungs-Datenbank der WHO registrierten Herzrhythmusstörungen unter Ginkgo können diesem Mittel eindeutig zugeschrieben werden. Dennoch soll an diese Möglichkeit gedacht werden, da Ginkgo kein sehr überzeugendes Nutzenprofil aufweist.
Patients’ Experiences of Ending Massage Therapy Care: A Commentary
Authors: Baskwill, PhD, MSc, BEd, RMT Amanda , Michaud, BA, RMT2 Suzanne 
Published: December 2020

Patients are best positioned to provide information about their experiences of healthcare services; however, their perspectives are often underutilized. During informal discussions with massage therapists (MTs), and through the authors’ own professional experiences, it was noted that there are times when patients decide independently, and without notice, to end the care they are receiving. To date, no research has been published exploring the experiences of patients who choose to discontinue massage therapy care and there is a gap in the quality assurance process of MTs. Lack of understanding of patients’ experiences is a missed opportunity to strengthen the therapeutic relationship, ensure patient safety, improve treatment quality, and develop professionally. To affect change within multiple levels of the profession so that patients’ experiences are valued and solicited in a manner that allows patients to provide critical feedback, we recommend two initial actions. First, we challenge massage therapy stakeholders to consider alternate research methodologies and methods to explore this phenomenon. Second, we recommend that MTs cultivate an appreciation for constructive criticism and actively listen to their patients with confidence.
Wideband Monitoring Observations of PSR J1803–3002A in the Globular Cluster NGC 6522
Authors: Zhang Lei , Manchester Richard N. , Cameron Andrew D. , Hobbs George , Li Di , Dai Shi , Zhi Qijun , Zhu Zonghong , Wang Jingbo , Toomey Lawrence , Feng Yi , Wang Shuangqiang , Zhang Songbo 
Published: December 2020

Abstract
We report the first wideband monitoring observations of PSR J1803−3002A, a relatively bright millisecond pulsar (MSP) in the globular cluster NGC 6522 with a spin period of 7.1 ms and no known binary companion. These observations were performed using the Parkes 64 m radio telescope with the Ultra-Wideband Low receiver system, which covers 704–4032 MHz. We confirm that PSR J1803−3002A is an isolated MSP located near the cluster center and probe the emission properties of the pulsar over the wide observed band. The mean pulse profile consists of three components, with the outer components becoming more prominent at higher frequencies, and a mean spectral index for the pulsed emission of −1.66 ± 0.07 over the observed band. The fractional linear and circular polarization increase with increasing frequency, which is unusual for pulsars. We determine a Faraday rotation measure of −107 ± 6 rad m−2 for the pulsar. PSR J1803−3002A is a distant pulsar in the Galactic plane, but our observations show no evidence of pulse broadening due to interstellar scattering. These results demonstrate the power of ultra-wideband receivers and signal processing systems.
An 8.8 Minute Orbital Period Eclipsing Detached Double White Dwarf Binary
Authors: Burdge Kevin B. , Coughlin Michael W. , Fuller Jim , Kaplan David L. , Kulkarni S. R. , Marsh Thomas R. , Bellm Eric C. , Dekany Richard G. , Duev Dmitry A. , Graham Matthew J. , Mahabal Ashish A. , Masci Frank J. , Laher Russ R. , Riddle Reed , Soumagnac Maayane T. , Prince Thomas A. 
Published: December 2020

Abstract
We report the discovery of ZTF J2243+5242, an eclipsing double white dwarf binary with an orbital period of just 8.8 minutes, the second known eclipsing binary with an orbital period of less than 10 minutes. The system likely consists of two low-mass white dwarfs and will merge in approximately 400,000 yr to form either an isolated hot subdwarf or an R Coronae Borealis star. Like its 6.91 minute counterpart, ZTF J1539+5027, ZTF J2243+5242 will be among the strongest gravitational-wave sources detectable by the space-based gravitational-wave detector the Laser Space Interferometer Antenna (LISA) because its gravitational-wave frequency falls near the peak of LISA's sensitivity. Based on its estimated distance of

, LISA should detect the source within its first few months of operation and achieve a signal-to-noise ratio of 63 ± 7 after 4 yr. We find component masses of

and

, radii of

and

, and effective temperatures of

and

. We determine all of these properties and the distance to this system using only photometric measurements, demonstrating a feasible way to estimate parameters for the large population of optically faint (r > 21 m

AB
) gravitational-wave sources that the Vera Rubin Observatory and LISA should identify.
Les réunions Narcotiques Anonymes pendant le confinement : plus de deux mois d’entraide et de réunions virtuelles
Authors: Membres de Narcotiques Anonymes Caroline et Patrick 
Published: December 2020

Cet article décrit la manière dont les groupes de Narcotiques Anonymes France se sont organisés, pendant les deux mois du confinement, pour continuer à fonctionner et faire en sorte que les dépendants puissent, malgré l’isolement, rester en lien. Dans cette période totalement inédite, l’organisation de réunions virtuelles a non seulement permis à ceux qui connaissaient la fraternité de continuer à se rétablir mais aussi à des nouveaux de rejoindre le mouvement. Finalement, la manière dont Narcotiques Anonymes a réussi à s’organiser pendant ces deux mois « hors du temps », s’est avérée efficace et riche d’enseignements.
Quand la direction décide d’un changement institutionnel : entre mythe fondateur, crise et examens de passage
Authors: Hanot Michel 
Published: December 2020

Quand la direction décide d’un changement institutionnel : entre mythe fondateur, crise et examens de passage – En 2003, je suis devenu le directeur d’une petite institution ayant deux ans d’ancienneté dans le secteur du handicap. La vie institutionnelle est faite de continuité et de changement. L’arrivée d’un nouveau directeur crée à la fois de l’incertitude et de l’espoir pour le personnel. Si, de surcroît, il est le dernier arrivé, il se retrouve dans la position paradoxale de devoir proposer une direction, un cap tout en ayant le moins d’informations et d’expérience concernant l’histoire institutionnelle, avec ses règles, ses croyances, son mythe fondateur. Arrive le moment où des changements sont nécessaires. Ceux-ci émergent à partir d’une ou plusieurs insatisfactions, parfois aussi à partir de nouveaux besoins. En tant que directeur, j’ai souhaité modifier l’offre de service à l’intention des bénéficiaires et procéder à une description de fonction du personnel. S’en est suivie une crise importante au sein de l’équipe car ces changements venaient modifier le mythe fondateur de l’institution, basé sur une indifférenciation des fonctions. J’ai été alors confronté à toute une série d’épreuves qui constituent de véritables examens de passage. Au terme de cette crise, un nouvel équilibre a émergé, apportant beaucoup de sérénité et de confort à l’ensemble de l’équipe ainsi qu’aux jeunes en situation de handicap.