bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraining the reionization history using deep learning from 21-cm tomography with the Square Kilometre Array
Authors: Mangena Tumelo , Hassan Sultan , Santos Mario G 
Published: March 2020

ABSTRACT
Upcoming 21-cm surveys with the SKA1-LOW telescope will enable imaging of the neutral hydrogen distribution on cosmological scales in the early Universe. These surveys are expected to generate huge imaging data sets that will encode more information than the power spectrum. This provides an alternative unique way to constrain the reionization history, which might break the degeneracy in the power spectral analysis. Using convolutional neural networks, we create a fast estimator of the neutral fraction from the 21-cm maps that are produced by our large seminumerical simulation. Our estimator is able to efficiently recover the neutral fraction ($x_{\rm H\,{\small I}}$) at several redshifts with a high accuracy of 99 per cent as quantified by the coefficient of determination R2. Adding the instrumental effects from the SKA design slightly increases the loss function, but nevertheless we are still able to recover the neutral fraction with a similar high accuracy of 98 per cent, which is only 1 per cent less. While a weak dependence on redshift is observed, the accuracy increases rapidly with decreasing neutral fraction. This is due to the fact that the instrumental noise increases towards high redshift where the Universe is highly neutral. Our results show the promise of directly using 21cm-tomography to constrain the reionization history in a model-independent way, complementing similar efforts, such as those of the optical depth measurements from the cosmic microwave background observations by Planck.
Contrapunto Fugato: A First Step Toward Composing in the Mind
Authors: Schubert Peter 
Published: March 2020

AbstractJessie Ann Owens marshaled evidence of a stage in Renaissance compositional process that did not use writing; Julie Cumming believes it was composers’ training as choirboys, which included improvisation, that enabled them to do this; and I propose that what they were doing was contrapunto pensado, Lusitano’s “thought-out” counterpoint, a category lying between on-the-spot improvisation and composition. This article details strategies for “composing in the mind” as it might have applied to a particular technique that singer/improvisers learned early on (after note-names, intervals, and rhythmic notation), called contrapunto fugato. It consists of singing a freely invented line containing repetitions of a motive against a cantus firmus (CF) in long equal values. Although this technique is easy to describe, no one has investigated the difficulties that are involved in repeating a motive against a CF. I will show what needs to be thought out beforehand (pensado) and what needs to be held in the mind so that the result can be sung immediately or written down later. The strategies that I “reverse engineer” from Lusitano’s examples give concrete reality to this ephemeral practice and offer a useful tool for our own pedagogy, for thinking about Renaissance music, and for refining our concept of improvisation. Lusitano’s examples are supplemented by examples by Banchieri and Ortiz.
A Prospective Cohort Study of Neural Progenitor Cell-Sparing Radiation Therapy Plus Temozolomide for Newly Diagnosed Patients With Glioblastoma
Authors: Gui Chengcheng , Vannorsdall Tracy D , Kleinberg Lawrence R , Assadi Ryan , Moore Joseph A , Hu Chen , Quiñones-Hinojosa Alfredo , Redmond Kristin J 
Published: March 2020

Abstract

BACKGROUND
In treating glioblastoma, irradiation of the neural progenitor cell (NPC) niches is controversial. Lower hippocampal doses may limit neurocognitive toxicity, but higher doses to the subventricular zones (SVZ) may improve survival.

OBJECTIVE
To prospectively evaluate the impact of limiting radiation dose to the NPC niches on tumor progression, survival, and cognition in patients with glioblastoma.

METHODS
Patients with glioblastoma received resection followed by standard chemoradiation. Radiation dose to the NPC niches, including the bilateral hippocampi and SVZ, was minimized without compromising tumor coverage. The primary outcome was tumor progression in the spared NPC niches. Follow-up magnetic resonance imaging was obtained bimonthly. Neurocognitive testing was performed before treatment and at 6- and 12-mo follow-up. Cox regression evaluated predictors of overall and progression-free survival. Linear regression evaluated predictors of neurocognitive decline.

RESULTS
A total of 30 patients enrolled prospectively. The median age was 58 yr. Median mean doses to the hippocampi and SVZ were 49.1 and 41.8 gray (Gy) ipsilaterally, and 16.5 and 19.9 Gy contralaterally. Median times to death and tumor progression were 16.0 and 7.6 mo, and were not significantly different compared to a matched historical control. No patients experienced tumor progression in the spared NPC-containing regions. Overall survival was associated with neurocognitive function (P ≤ .03) but not dose to the NPC niches. Higher doses to the hippocampi and SVZ predicted greater decline in verbal memory (P ≤ .01).

CONCLUSION
In treating glioblastoma, limiting dose to the NPC niches may reduce cognitive toxicity while maintaining clinical outcomes. Further studies are needed to confirm these results.
Formation of dynamically transversely trapping surfaces and the stretched hoop conjecture
Authors: Yoshino Hirotaka , Izumi Keisuke , Shiromizu Tetsuya , Tomikawa Yoshimune 
Published: March 2020

Abstract
A dynamically transversely trapping surface (DTTS) is a new concept for an extension of a photon sphere that appropriately represents a strong gravity region and has close analogy with a trapped surface. We study formation of a marginally DTTS in time-symmetric, conformally flat initial data with two black holes, with a spindle-shaped source, and with a ring-shaped source, and clarify that $\mathcal{C}\lesssim 6\pi GM$ describes the condition for the DTTS formation well, where $\mathcal{C}$ is the circumference and $M$ is the mass of the system. This indicates that an understanding analogous to the hoop conjecture for the horizon formation is possible. Exploring the ring system further, we find configurations where a marginally DTTS with the torus topology forms inside a marginally DTTS with the spherical topology, without being hidden by an apparent horizon. There also exist configurations where a marginally trapped surface with the torus topology forms inside a marginally trapped surface with the spherical topology, showing a further similarity between DTTSs and trapped surfaces.
Body weight and sex effects on digesta mean retention time in growing Saanen goats
Authors: Gindri Marcelo , Leite Rafael Fernandes , Härter Carla Joice , da Silva Simone Pedro , St-Pierre Normand , Fernandes Márcia Helena Machado da Rocha , Berchielli Telma Teresinha , Teixeira Izabelle Auxiliadora Molina de Almeida 
Published: March 2020

Abstract
Despite the important role of digesta mean retention time (MRT) on digestive efficiency of ruminants, it is poorly investigated in total gastrointestinal tract (GIT) of growing ruminants, especially in goats. The objective of this study was to evaluate the effect of body weight (BW) and sex on GIT MRT of particles and solutes in growing Saanen goats. A dataset from two studies, comprising 103 individual records of castrated males (n = 36), females (n = 34), and intact males (n = 33) Saanen goats slaughtered at 15, 22, 30, 37, and 45 kg BW, was used. Goats were fed basically with total mixed ration composed by dehydrated corn plant (Zea mays) milled to pass a 10-mm screen, cracked corn grain, and soybean (Glycine max) meal. Variables evaluated were BW, feed intake, feed intake level, composition of ingested diet, wet weight of GIT tissues, wet digesta pool size, digesta composition (dry matter and neutral detergent fiber [NDF]), indigestible NDF:NDF ratio of ingested diet and GIT digesta, MRT of particles (MRTiNDF) and solutes (MRTCr), and reticulorumen selectivity factors (large particles/solutes). Reticulorumen, omasum, abomasum, small intestine, cecum, and colon–rectum segments were evaluated. The dataset was analyzed as mixed models considering sex, BW, and sex × BW interaction as fixed effects, and study and residual error as random effects. Sex did not affect MRTiNDF in any GIT segments. Females and intact males presented similar reticulorumen MRTCr (5.6 h; P = 0.92) and they presented lower reticulorumen MRTCr than castrated males (7.0; P ≤ 0.04). Total GIT MRTCr was similar between castrated males and females (15.7 h; P = 0.11) and between females and intact males (14.2 h; P = 0.76). Body weight (BW) did not affect MRTiNDF in reticulorumen and colon–rectum and total GIT MRTCr (P ≥ 0.11). Reticulorumen and omasum MRTCr increased as BW increased (P &lt; 0.01), and abomasum MRTCr decreased as BW increased (P = 0.02). Feed intake, and wet tissues and wet pool size of all GIT segments increased as BW increased, except abomasum wet pool size (P ≤ 0.01). The mechanism related to sex effect on MRT has to be elucidated. Reticulorumen MRTiNDF and total GIT MRTCr were modulated by intake and capacity of reticulorumen and GIT, respectively. On the other hand, reticulorumen MRTCr seemed to be regulated by reticulo-omasal orifice opening and saliva secretion.
Age Inclusive Human Resource Practices, Age Diversity Climate, and Work Ability: Exploring Between- and Within-Person Indirect Effects
Authors: Rudolph Cort W , Zacher Hannes 
Published: March 2020

AbstractTo address the challenges imposed by demographic change, organizations have become increasingly interested in maintaining and improving employees’ work ability across the working life span. Based on signaling and social exchange theories, we present a study that investigates the indirect influence of age inclusive human resource practices (AIHRP) on work ability through age diversity climate (ADC). Using a 6-wave longitudinal study of n = 355 employees, we model between- and within-person mediated effects using a random intercept cross-lagged panel model. The results of this analysis partially support our mediation hypothesis. Specifically, we found evidence that ADC mediates the influence of AIHRP on work ability at the between-, but not at the within-person level of analysis. These findings have implications for the development of human resource practices that benefit employees at various ages.
Associations Among Childhood Household Dysfunction, Sexual Orientation, and DSM-5 Alcohol, Tobacco and Other Substance Use Disorders in Adulthood: Evidence From a National U.S. Survey
Authors: McCabe Sean Esteban , Hughes Tonda L. , West Brady T. , Evans-Polce Rebecca , Veliz Phil , Dickinson Kara , Hoak Sebastian , Boyd Carol J. 
Published: March 2020

Objectives:
This study examined the associations between childhood household dysfunction and adulthood past-year DSM-5 alcohol, tobacco, and other substance use disorders across sexual orientation subgroups (eg, lesbian/gay, bisexual, and heterosexual).

Methods:
Prevalence estimates were based on National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III) data collected from structured diagnostic face-to-face interviews in a nationally representative sample of 36,309 U.S. adults. Multivariable regression was used to examine associations between childhood household dysfunction and past-year substance use disorders in adulthood.

Results:
Sexual minorities, particularly sexual minority women, reported higher rates of childhood household dysfunction (eg, parental/household history of substance-related problems) and adulthood DSM-5 alcohol, tobacco, and substance use disorders. Results of multivariable analyses indicated that childhood histories of parental/household substance-related problems were associated with greater odds of past-year substance use disorders among sexual minorities than heterosexuals, and that such histories may moderate differences among sexual orientation subgroups. The risk of substance use disorders among sexual minority women relative to exclusively heterosexual women (ie, heterosexual-identified women without same-sex attraction or behavior) remained high, even when accounting for household dysfunction. In contrast, there were no such differences between sexual minority men and exclusively heterosexual men.

Conclusions:
Sexual minorities are more likely to have childhood household dysfunction which in turn is associated with a higher risk of developing DSM-5 alcohol, tobacco, and substance use disorders in adulthood, especially among sexual minority women. Healthcare providers who care for individuals raised in dysfunctional households should carefully assess risk for substance use disorders and intervene as needed.
Surgical Outcomes of Postural Instability in Patients With Cervical Myelopathy
Authors: Yano Toma , Fujishiro Takashi , Obo Takuya , Mori Katsunori , Hayama Sachio , Nakaya Yoshiharu , Nakano Atsushi , Baba Ichiro , Neo Masashi 
Published: March 2020

Study Design:
This is a retrospective study.

Objective:
The objective of this study was to investigate the surgical outcomes of postural instability and its predictors in patients with cervical myelopathy (CM).

Summary of Background Data:
Although several studies have shown impaired postural stability in CM patients, there remains a paucity of literature examining its surgical outcome.

Materials and Methods:
Postural stability was assessed using a stabilometer preoperatively, at the early phase (3–6 months postoperatively), and 1-year postoperatively, employing 2 stabilometric parameters: sway area [SwA (cm2): the amount of sway of gravity center assessed by the outer peripheral area of the stabilogram] and sway density [SwD (/cm): the indicator of proprioceptive reflexes calculated by the locus length of the stabilogram per SwA]. Twenty-seven healthy age-matched, sex-matched, and body mass index-matched subjects were recruited as controls. To investigate the predictors of postoperative postural instability, univariate, and multivariate analyses were performed, including demographic data, preoperative neurological symptom severity, radiographic findings, and preoperative stabilometric parameters as independent variables.

Results:
Altogether, 54 CM patients were included in the present study. SwA was 7.89±0.84, 4.78±0.68, and 4.85±0.49, and SwD was 14.63±0.85, 20.41±1.23, and 19.36±1.40 preoperatively, at the early phase, and 1-year postoperatively, respectively, and significant improvement was found in both parameters postoperatively. However, at all timepoints, these parameters were significantly worse in CM patients than in the healthy subjects (SwA: 2.68±0.24, SwD: 24.91±1.83). Multivariate analyses showed that worse preoperative stabilometric parameters were significantly related to worse postoperative stabilometric parameters.

Conclusions:
Surgery significantly improved postural stability in CM patients; however, it did not reach the level observed in healthy controls, even postoperatively. A predictor of greater residual postoperative postural instability was a greater level of preoperative postural instability. In CM patients, to achieve better surgical outcome of postural stability, surgical intervention is recommended before the symptoms related to bodily imbalance deteriorate.

Level of Evidence:
Level III.
Rian/miR-210-3p/Nfkb1 Feedback Loop Promotes Hypoxia-Induced Cell Apoptosis in Myocardial Infarction Through Deactivating the PI3K/Akt Signaling Pathway
Authors: Zhong Lihua , Jia Jing , Ye Guohui 
Published: March 2020

Abstract:
Myocardial infarction (MI) is a severe disease that could lead to reversible or irreversible ischemic heart damage. A previous study has revealed that microRNA mmu-miR-210-3p expression is downregulated in fat-1 transgenic mice post-MI. Nevertheless, the specific mechanism of miR-210-3p in MI remains obscure. In this study, we observed that miR-210-3p expression was downregulated in the mice's left ventricle post-MI, and miR-210-3p expression was suppressed while cell apoptosis was promoted in H9c2 cells under hypoxia condition. Besides, miR-210-3p overexpression could enhance cell proliferation and inhibit cell apoptosis in hypoxia-treated H9c2 cells. Then, molecular mechanism assays revealed that miR-210-3p overexpression could activate the PI3K/Akt pathway, and nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (Nfkb1) was the target of miR-210-3p. In addition, RNA imprinted and accumulated in nucleus (Rian), a long noncoding RNA, could sponge miR-210-3p to upregulate Nfkb1 expression. Besides, Nfkb1 was verified to facilitate the transcription of Rian by binding with a Rian promoter. Furthermore, rescue assays revealed that both Nfkb1 and PI3K/Akt pathway are engaged in the Rian-mediated cell proliferation and apoptosis in hypoxia-treated H9c2 cells. In conclusion, a Rian/miR-210-3p/Nfkb1 feedback loop enhances hypoxia-induced cell apoptosis in MI through deactivating the PI3K/Akt pathway.
Distribution and linkage disequilibrium of the enhancer SNP rs5758550 among Latin American populations: influence of continental ancestry
Authors: Elias Anna Beatriz Ribeiro , Araújo Gilderlanio Santana de , de Souza Sandro José , Suarez-Kurtz Guilherme 
Published: March 2020

Objectives
A single nucleotide polymorphism (SNP), rs5758550, in a critical enhancer region downstream of the CYP2D6 promoter was proposed to modulate CYP2D6 activity, depending on its linkage disequilibrium (LD) with the common CYP2D6 SNP, rs16947. We examined the influence of individual biogeographical ancestry on the frequency distribution of rs5758550 and its LD with rs16947 in Latin American populations. We then inferred the impact of rs5758550 on the predictive accuracy of CYP2D6 metabolizer status based on CYP2D6 haplotypes.

Methods
The study cohorts consisted of the Admixed American (AMR) superpopulation of the 1000 Genomes Project (n = 347) plus an admixed Brazilian (BR) cohort (N = 224). Individual proportions of Native, African and European ancestry estimated by ADMIXTURE analysis, were used to design four sub-cohorts, in which one of the three ancestral roots predominated largely (>6 fold) over the other two: AMR-NAT and AMR-EUR, comprised 80 AMR individuals each, with >70% Native or >70% European ancestry, BR-EUR and BR-AFR comprised Brazilians with >90% European (n = 80) or >70% African ancestry (n = 64), respectively. CYP2D6 haplotypes were inferred based on 10 commonly reported CYPD6 variants with or without addition of the enhancer rs5758550 SNP, pairwise LD was assessed by the R2 parameter, and activity scores were used to infer CYP2D6 metabolizer status.

Results
Minor allele frequency (MAF) of all CYP2D6 SNPs, except the rare (<0.02) rs5030656 and rs35742688, differed significantly across sub-cohorts, whereas no difference was observed for rs5758550. The R2 values for LD between rs5758550 and rs16947 ranged from 0.15 (BR-AFR) to 0.85 (AMR-NAT), with intermediate values in the predominantly European sub-cohorts (0.34–0.67). As a consequence, distribution of CYP2D6 haplotypes containing the rs16947 SNP plus rs5758550 wild-type (A) or variant (G) allele differed markedly across sub-cohorts. Comparison of the CYP2D6 activity scores assigned to the wild-type (CYP2D6*1) and the rs16947-containing haplotypes with or without inclusion of rs5758550, showed that knowledge of the rs5758550 genotype has negligible impact on predicted CYP2D6 phenotypes in AMR-EUR and AMR-NAT, but affects prediction in 10.7 and 21.6% of BR-EUR and BR-AFR individuals, respectively.

Conclusion
Collectively, the present results reveal potential pharmacogenomic (PGx) implications of the population diversity in Latin America, affecting a major drug-metabolizing pathway. Thus, the influence of enhancer rs5758550 on assignment of CYP2D6 metabolic phenotypes varies markedly, according to the individual proportions of Native, European and African ancestry. This conclusion reinforces the notion that extrapolation of PGx data across the heterogeneous Latin American is risky, if not inappropriate.
Scheimpflug Corneal Densitometry Changes After the Intrastromal Corneal Ring Segment Implantation
Authors: Sedaghat Mohammad-Reza , Momeni-Moghaddam Hamed , Heravian Javad , Belin Michael W. , Ambrósio Renato , Gheysari-Alishahi Tayebe , Ghavami Seyyed Hossein 
Published: March 2020

Purpose:
To investigate the changes in corneal backward scattering using Scheimpflug tomography (densitometry) 6 months after intrastromal corneal ring segments (Keraring) implant for keratoconus and to correlate with clinical results.

Methods:
Along with standard ophthalmic examination, Scheimpflug tomography using Pentacam HR was performed to document corneal densitometry and corneal shape. A densitometry map was displayed using grayscale units (GSUs) ranging from 0 to 100 (minimum to maximum light scattering) in 4 concentric annuluses: central 2-, 2- to 6-, 6- to 10-, 10- to 12-, and total 12-mm corneal diameter and at 3 different depths: anterior 120 μm, posterior 60 μm, middle (varying accordingly to the total thickness), and total thickness.

Results:
The changes in mean corneal densitometry values for anterior, central, and posterior layers were 3.82 ± 3.13, 2.70 ± 1.78, and 1.68 ± 1.52 GSU, respectively, and for annuluses of 0 to 2, 2 to 6, 6 to 10, and 10 to 12 mm were 2.96 ± 2.60, 4.53 ± 2.28, 2.09 ± 1.74, and 0.45 ± 3.93 GSU, respectively. The mean values increased for all corneal layers (P < 0.05), except in the peripheral 10- to 12-mm annulus (P> 0.05). The highest increase was in the annulus 2 to 6 mm of the anterior layer (5.72 ± 3.70 GSU). Changes in the mean densitometry showed a significant correlation with the mean of average keratometry changes only for the front corneal surface and changes in the Q-values for both corneal surfaces in the 2- to 6-mm annulus for all layers.

Conclusions:
Significant increase in the corneal densitometry mainly in the anterior 2- to 6-mm annulus of the cornea is associated with the position of the ring segment implant. More studies are needed to elucidate the relevance of such findings.
Corneal Densitometry in Diabetes Mellitus
Authors: Ramm Lisa , Spoerl Eberhard , Pillunat Lutz E. , Terai Naim 
Published: March 2020

Purpose:
Chronic hyperglycemia induces morphological and functional changes of the cornea. Corneal clarity is essential for visual function, and the measurement of corneal optical density (COD) might provide further information on diabetes mellitus (DM)–induced alterations.

Methods:
COD of patients with DM and age-matched healthy subjects was measured using the Pentacam HR. Furthermore, central and thinnest corneal thickness and peripheral pachymetry of concentric circles around thinnest corneal thickness were investigated. In DM, information on disease duration, type, presence of diabetic retinopathy and maculopathy, and HbA1c value was recorded.

Results:
In this study, 76 patients with DM and 65 healthy subjects were included. In patients with DM, the COD values of nearly all corneal layers and zones were reduced in comparison with healthy subjects (P < 0.05). Furthermore, the COD measurements were inversely correlated with the HbA1c value (total COD central layer: r = −0.424, P = 0.044) and stage of diabetic retinopathy (total COD: r = −0.271, P = 0.019). Diabetic patients with maculopathy revealed lower total COD values than patients without maculopathy (16.5 ± 5.6 vs. 21 ± 7.6, P = 0.031), and COD was lower in DM type 1 than in type 2 (16.1 ± 5.1 vs. 20.8 vs. 7.5, P = 0.035). In both groups, the COD values increased with age (patients with DM: r = 0.336, P = 0.003; healthy subjects: r = 0.679, P < 0.001) and decreased with peripheral corneal thickness increase.

Conclusions:
In patients with DM, COD was significantly reduced in comparison with healthy subjects. These changes were associated to disease-specific factors and measurements of peripheral corneal thickness profiles.