bluuebunny/crossref_metadata_2025_split huggingface dataset:
P365Does papillary muscle ablation affect mitral valve function: a single centre experience
Authors: Stassen J , Dilling D , Vijgen J , Schurmans J , Koopman P 
Published: June 2020

Abstract

Introduction
Ventricular arrhythmias from papillary muscles (PMs) often require extensive catheter ablation (CA). Not much is known about the mitral valve (MV) function after these extensive catheter ablations.

Purpose
The goal of this study was to determine the impact of papillary muscle CA on MV function.

Methods
We retrospectively examined echocardiographic measurements in 21 patients with frequent premature ventricular contractions (PVCs) originating from the mitral PMs who underwent CA, dating from October 2012 till November 2018. We assessed MV function at baseline, 6 month and last follow-up. Degree of mitral regurgitation (MR) was graded as mild (ERO &lt;0,2 cm2, regurgitation volume (RV) &lt;30ml), moderate (ERO 0,2-0,4cm2, RV 30-59ml) or severe (ERO ≥0,4cm2, RV ≥60ml). Significant MR was defined as a 2+ change.

Results
Mean age of the study population was 59,7 (27-80)years, 52,4% was female.
2 patients were known with ischemic heart disease. There was a family history of sudden cardiac death in 3 patients. Main symptoms at presentation were palpitations (66,7%), fatigue (33,3%), dyspnea (33,3%, all NYHA 2), dizziness (28,6%), angina pectoris (14,3%) and syncope (4,8%). Beta blocker (71,4%), flecaïnide (23,8%), amiodarone (9,5%), sotalol (4,8%) and propafenon (4,8%) were the most frequent medical therapies before CA.
Mean burden of PVC before ablation was 15 574 (2000-39700)/24h. In 28,6% non sustained VT was documented, 1 patient suffered a sustained episode of VT. After ablation, mean burden of PVC was reduced to 1331 (0-14200)/24h. Redo ablation was necessary in 28,6% of patients. PVCs orginated from the anterolateral PM in 33,3% and from the posteromedial PM in 66,7%. Mean troponin release was 9.4 ± 5.3 µg/l, mean troponin hs (since 2016) was 1591.0 ±658.6ng/ml. CMR was done in 14/21 (66,7%) patients before CA. In 5 out of 14 patients (35,7%), delayed enhancement at the papillary muscles was noticed. In 5 patients without delayed enhancement, CMR was repeated after CA. In all these 5 patients, delayed enhancement was noticed at the level of the papillary muscles.
At baseline, 15/21 had mild, 5/21 moderate and 1/21 severe MR. There was no significant chance in MR at 6m follow-up with 15/21 having mild and 6/21 moderate MR (p 0.58) with 1 patient having a significant MR 2+ change. At last follow-up (23.7 ± 22.6 months) there was also no significant chance in MR with 15/21 having mild and 6/21 moderate MR (p 0.58) without a significant MR 2+ change.
Complications occurred in 1 patient (transient AV blok). No patients died during follow up.

Conclusions
Although PM ablation was associated with time extensive ablation, significant troponine release and documented delayed enhancement on post ablation MRI, there was no risk of additional valvular dysfunction after CA in this study. Larger studies will be necessary to confirm these findings.
862Syncav with multipoint pacing improves acute left ventricular hemodynamics
Authors: Chow A , Waddingham P , Betts T , Mangual J , Badie N , Mcspadden L , Pappone C , Calo L , Leyva F , Thibault B 
Published: June 2020

Abstract

Funding Acknowledgements
Abbott

Introduction
SyncAV has been shown to improve electrical synchronization by automatically adjusting atrioventricular delay (AVD) according to the intrinsic atrioventricular conduction time. Additional incremental electrical synchronization may be gained by the addition of second left ventricular (LV) pulse with MultiPoint Pacing (MPP). While the electrical synchronization benefits of SyncAV have been previously explored, there has been no assessment of the acute hemodynamic impact of SyncAV with or without MPP.

Objective
Evaluate the acute LV hemodynamic impact of SyncAV with and without MPP.

Methods
Heart failure patients with LBBB and QRS duration (QRSd) &gt; 140 ms undergoing CRT-P/D implant with a quadripolar LV lead were enrolled in this prospective study. A guidewire or catheter with pressure transducer was placed in the LV chamber and the maximum pressure change (dP/dtmax) was recorded during the following pacing modes: intrinsic conduction, conventional biventricular pacing with SyncAV (BiV + SyncAV), and MPP with SyncAV (MPP + SyncAV). Twelve-lead surface ECG was used to determine the patient-tailored SyncAV offset that minimized QRSd.

Results
Twenty-seven patients (67% male, 44% ischemic, 30 ± 7% ejection fraction) completed the acute recordings. Relative to the intrinsic QRSd of 163 ms, BiV + SyncAV reduced QRSd by 21.5% to 124 ms (p &lt; 0.001 vs. intrinsic) and MPP + SyncAV reduced QRSd by 26.6% to 120 ms (p &lt; 0.05 vs. BiV + SyncAV). Beyond electrical synchronization, SyncAV significantly improved acute hemodynamics. Relative to the intrinsic dP/dtmax of 842 mmHg/s, BiV + SyncAV elevated dP/dtmax by 6.3% to 900 mmHg/s (p &lt; 0.001 vs. intrinsic) and MPP + SyncAV elevated dP/dtmax by 8.8% to 926 mmHg/s (p &lt; 0.005 vs. BiV + SyncAV). Despite both QRSd and dP/dtmax improvement with SyncAV and MPP, correlation between electrical and hemodynamic measurements was poor (R2 = 0.0 for BiV + SyncAV, R2 = 0.1 for MPP + SyncAV).

Conclusion
SyncAV may significantly improve acute LV hemodynamics in addition to electrical synchrony in LBBB patients. Further incremental improvement was achieved by combining SyncAV with MPP.
Abstract Figure.
1265The results of whole exome sequencing in patients with bradyarrhythmias
Authors: Polyakova E , Shcherbakova N 
Published: June 2020

Abstract
Introduction. Sick sinus syndrome (SSS) and atrioventricular block (AVB) are life-threatening cardiac arrhythmias, that sometimes can manifest itself with syncope and needs a pacemaker implantation even in children. Sometimes, SSS and AVB are accompanied by structural heart diseases such as septal defects, cardiomyopathies, but often the heart is structurally normal. Some genes associated with bradyarrhythmias are well known. At the same time, the etiology of the SSS is unidentified and may be genetic caused in 50% of patients with SSS. There are no studies on the prevalence of with bradyarrhythmia-associated mutations in children.
The purpose of our work is to identify and study the types of mutations associated with SSS and AVB in children.
Methods. We included in the study 15 patients (27% boys) with severe SSS and AVB, from the database of the Russian Pediatric Arrhythmia Center. 11 were the probands and 4 - family members. Personal and family history, physical examination, including ECG, stress test, Holter monitoring, ECHO and other tests, and whole exome sequencing were made. The average age was 14.1 ± 4.5 (from 2 to 17).
Results. In 30% (5 pts) there was the combination of with bradyarrhythmias and structural heart disease. 7 pts (47%) had syncope, 4 pacemakers were implanted. 10 children (67%) had the genetic variants of genes associated with SSS and AVB: SCN5A, TNNI3K, KCNA5, TRPM4, ANK2 and others. Family history of cardiac diseases was positive in 5 probands; 2 probands had family members with implanted pacemakers. In 3 pts were likely pathogenic variants and in 7 pts - variants of unknown significance found.
Conclusion. We found the genetic cause of bradyarrhythmias in 67% of children. Further research and larger patient samples are required to study the prevalence of genetic types of and show the correlation of the genotype with the clinical prognosis.
In addition, our work will enable practitioners to identify children from families with family forms of SSS, AVB and sudden cardiac death. Further research can help us determine the criteria for selecting children for genetic testing.
P318Positive left ventricular remodeling after TAVI assessed by high resolution electrocardiography
Authors: Vitez L , Krajacic B , Starc V , Bunc M 
Published: June 2020

Abstract

Introduction
Transcatheter aortic valve replacement (TAVI) is a novel treatment method for sever aortic stenosis that has a positive impact on reverse left ventricular (LV) remodeling. The morphology and function of the LV can be assessed by transthoracic echocardiography (TTE) and high resolution electrocardiography (HR-ECG).

Purpose

The purpose of our study was to investigate whether morphological and functional myocardial changes after TAVI seen on TTE can be tracked by advanced ECG parameters using HR-ECG.

Methods
Consecutive TAVI patients with transfemoral approach were included in this pilot prospective study. A 5 minute HR-ECG and TTE were performed before and one year after TAVI. Spatial QRS vector amplitude (3D_QRSm), total 12-lead QRS amplitude (12leadV), spatial QRS-T angle (QRST_aM) and spatial ventricular gradient (SVG) were measured using HR-ECG and interventricular septum diastolic diameter (IVSd), left posterior wall diameter (LVPWd), left ventricular ejection fraction (LVEF) and tissue Doppler peak septal systolic velocity (Sm) were obtained by TTE. Student"s test was used for pairs to analyze the differences in sets of variables before and after TAVI and Pearson correlation coefficient to analyze the relationship between TTE and HR-ECG parameters.

Results
15 patients (5 male; 33.3%) were included in the study. At one year follow-up we found statistically significant reduction in LV wall thickness and increase in LVEF (61.6 ± 6.50 % vs. 66.9 ± 7.84 %, p = 0.043). In the subgroup with narrow QRS (8 patients), we found a statistically significant correlation between change of left posterior wall thickness (deltaLVPW) and spatial QRS vector amplitude (delta3D_QRSm) (r = 0.795; p = 0.018), and between change of left ventricular ejection fraction (deltaLVEF) and spatial QRS-T angle (deltaQRST_aM) (r = 0.604; p = 0.038). No significant correlations were found in the subgroup of patients with wide QRS complex.

Conclusions
Our pilot study showed that morphological and functional myocardial changes after TAVI in patients with narrow QRS complex can be followed with advanced ECG parameters using HR-ECG. HR-ECG could prove to be a simple and inexpensive method of follow-up after TAVI in patients with narrow QRS. To ascertain the usefulness and reliability of HR-ECG, a study on a larger number of patients would be required.
P1166Women as candidates for CRT: Are they less but better?
Authors: Aguiar-Ricardo I , Nunes-Ferreira A , Rigueira J , Rdrigues T , Cunha N , Antonio P S , Morais P , Pereira S C , Bernardes A , Santos I , Magalhaes A , Neves H , Pinto F J , De Sousa J , Marques P 
Published: June 2020

Abstract

Introduction
Women have been under-represented in trials of cardiac resynchronization therapy (CRT). Most available data suggest that CRT has a greater clinical benefit in women than in men. However, further studies are needed to investigate the exact reasons for these results.

Purpose
To compare the prognostic impact and response rate of CRT in women and man.

Methods
Prospective study, single-center study that included pts undergoing CRT implant from 2015 to 2019. Clinical and echocardiographic evaluation were made before CRT implant and between 6-12 months post-implant. Pts with EF elevations≥10% or LV end-systolic volume (ESV) reductions≥15% were classified as responders. Patients with EF elevations ≥ 20% or ESV reductions≥30% were classified as super-responders. All the parameters were compared between women and man. Prognostic impact of CRT was evaluated as total mortality by the Cox regression and Kaplan-Meier methods.

Results
From 2015-2019, 561 patients were submitted to CRT implant with a follow-up duration of 18.9 ± 15.8 months. From these 148 (26.4%) were female (mean age 72.2 ± 10 years, 22.4% ischemic, LVEF &lt; 30% in 70.2%). The cardiovascular risk factors and comorbidities were similar in both populations (women and men). In the female group, dilated cardiomyopathy was more frequent than in men (71% vs 50.8%, p &lt; 0.01), with ischemic heart disease being the second most frequent etiology of heart failure.
The frequency of LBBB was similar in both groups (63.9% in women and 57.0% in men, p = NS) however the QRS duration was higher in women (164 ± 17 vs 160 ± 24, p = 0.017). The baseline mean EF was similar (30.5 ± 10.3ms in women and 30.3 ± 11.4ms in men) but the ESV was lower (109.7 ± 59.9 vs 138.4 ± 64.6, p &lt; 0.001).
The prevalence of complications and need for surgical revision were similar in both groups.
The rate of CRT responders was similar in both groups, although tendentially higher in women (64.3% in women vs 55.2% in men, p = NS). On the other hand, super-responder rate was statistically significant (38% in women vs 25.1% in men, p = 0.004). The long-term survival was similar in both groups.

Conclusion
The rate of super-responders was higher in women than in men. This may be explained by the higher prevalence of dilated cardiomyopathy in this subgroup of patients and by the fact that women have smaller hearts and a larger QRS duration at baseline, most likely to have a real LBBB. Long-term mortality of CRT was not gender related
Abstract Figure. Long-term survival by gender
1244Feasibility, safety and efficacy of tailoring ablation index to left atrial wall thickness (lawt) during atrial fibrillation ablation. The Ablate By-LAW Study
Authors: Teres C , Jauregui B , Soto-Iglesias D , Ordonez A , Chauca A , Ramirez C , Oller G , Jornet A , Palet J , Padro J , Maldonado G , Panaro A , Carballo J , Penela D , Berruezo A 
Published: June 2020

Abstract

Funding Acknowledgements
Dr Teres was funded by Swiss Heartrhythm Foundation

Introduction
Circumferential pulmonary vein isolation (PVI) has become a mainstay in the treatment of atrial fibrillation (AF). The utility of ablation index (AI) to dose radiofrequency delivery for the reduction of AF recurrences has already been proven with a target AI ≥ 400 at the posterior wall and ≥550 at the anterior Wall. Nevertheless, the left atrial wall is a thin, heterogeneous structure with an important inter and intra-patient variability of LAWT.

Objective
To determine if adapting AI to atrial wall thickness (AWT) is feasible, effective and safe during AF ablation.

Methods
Single-Center study that included 80 consecutive patients referred for a first paroxysmal AF ablation that was performed with a single catheter approach with the intention to reduce vascular access complication rate. All patients had a MDCT prior to the ablation procedure. LAWT maps were semi-automatically computed from the MDCT as the local distance between the LA endo and epicardium. All procedures were performed under general anesthesia with a high-rate low-volume ventilation protocol for obtaining higher catheter stability. The transeptal puncture was TEE-guided. During the procedure, the WT map was fused with the LA anatomy using CARTO-merge. LAWT was categorized into 1mm-layers and the AI was titrated to the local atrial WT as follows: Thickness &lt; 1 mm (red): 300; 1-2 mm (yellow): 350; 2-3 mm (green): 400; 3-4 mm (blue): 450; &gt; 4 mm (purple): 450 (Figure). Maximal inter-lesion distance was set at 6 mm. VisiTag settings were: catheter position stability: minimum time 3 s, maximum range 4 mm; force over time: 25%, minimum force 3 g; lesion tag size: 3 mm. Respiration training was not possible due to the high catheter stability. The circumferential ablation line was designed in a personalized fashion to avoid thicker regions.

Results
80 patients [41 (51,2 %) male, age 60± 11 years] were included. Mean LVEF was 59 ± 5 %, Mean LA diameter 39,1 ± 5,8 mm, Mean LAWT was 1.36 ± 0.63 mm. Mean AI was 352 ± 36 on the RPVs and 356 ± 36 on the LPVs. Procedure time was 60,0 min (IQR 51-70). Fluoroscopy time was 58,5 s (35-97,5). First pass isolation was obtained in 72 (90%) of the RPVs and 75 (93,8%) of the LPVs.

Conclusions
the present study, assessing a novel, personalized protocol for radiofrequency titration during atrial fibrillation ablation, shows a high rate of first pass isolation with a lower need for RF energy delivery and lower procedure requirements, as compared to previous PV ablation protocols. Further studies are needed to evaluate the long-term results of this approach.
Abstract Figure. LAWT-map Visitag points with tailored AI
659Left atrial wall thickness evaluation during atrial fibrillation redo procedures
Authors: Teres C , Soto D , Jauregui B , Penela D , Ordonez A , Chauca A , Ramirez C , Oller G , Jornet A , Palet J , Santana D , Panaro A , Maldonado G , Carballo J , Berruezo A 
Published: June 2020

Abstract

Funding Acknowledgements
Dr Teres was funded by Swiss Heartrhythm Foundation

Introduction
pulmonary vein (PV) reconnections due to gaps on circumferential ablation lines are responsible for atrial fibrillation recurrences after catheter ablation. We sought to analyze the local left atrial wall thickness (LAWT) of PV line gaps at AF redo ablation during real-time catheter positioning. LAWT was measured on the MDCT 3D reconstruction and fused with the LA anatomy using CARTO-merge.

Objective
To analyze the relationship between local reconnection gaps and the LAWT during AF redo procedures.

Methods
Single-Center cohort study that included 41 consecutive patients referred for AF redo procedure. All patients had a MDCT prior to the ablation procedure. LAWT maps were semi-automatically computed from the MDCT as the local distance between the LA endo and epicardium. Each PV line was subdivided into 8 segments and mean LAWT was computed. During the procedure, the local gap was defined as the earliest activation site at the reconnected segment of the circumferential PV line (Figure 1A & 1B).

Results
41 patients [31 (75.6%) male, age 60 ± 10 years] were included. Mean LAWT was 1.36 ± 0.20 mm. Mean PV circumferential line WT was higher in left PVs than in the right PVs 1.68 ± 0.57 vs. 1.31 ± 0.39 mm p &lt; 0.001 respectively. Mean WT of the reconnected points was 44% higher than the mean WT of the segment where the reconnection was located. Mean reconnection point WT was at the 87th percentile of the circumferential line in the LPVs and at the 76th percentile in the RPVs. The reconnected point WT was higher in the LPVs than RPVs 2.13 ± 1.14 vs. 1.47 ± 0.48 mm p &lt; 0.001 respectively. The most frequent location for reconnections was the left anterior carina (71%), with a mean WT of 2.24 ± 0.91mm; and the right anterior carina (56%) with a mean WT of 1.57 ± 0.62mm (Figure 2A & 2B).

Conclusions
Reconnection points were more frequently present in the thicker segments of the PV circumferential line. The most frequently reconnected segment was the anterior carina in both right and left PVs. Atrial wall thickness maps derived from MDCT are useful to guide AF redo procedures.
Abstract Figure. 1) Activation & WT map; 2) Segment WT
232Accessory pathway ablation in adults: estimated additional cancer risk depending on the mapping and ablation strategy
Authors: Bastian D , Buia V , Rordorf R , Petracci B , Walascheck J , Vicentini A , Muca M , Savastano S , Sanzo A , Rittger H , Vitali Serdoz L 
Published: June 2020

Abstract

Introduction
Catheter ablation is the treatment of choice for accessory pathways (AP) in high risk patients and it´s usually performed under fluoroscopy guidance (reported X-Ray time:16 -38min).Radiation exposure is associated with an increased incidence of dermatitis,gene defects, cataract and malignancy.3-D mapping systems(EAMS) can reduce fluoroscopy exposure.

Purpose
To evaluate the additional cancer risk throughout life in 2 homogeneous adult populations of high-risk APs treated either with conventional fluoroscopically guided ablation (CFA) or with an EAM- and echocardiography(TEE or ICE)guided minimally fluoroscopic ablation approach (MFA).Methods: 2 Center study, 60 consecutive pts enrolled; 31pts underwent CFA at IRCCS Policlinico san Matteo (Pavia) and 29 pts underwent EAM guided MFA at Klinikum Fuerth between 01/2016 and 09/2019.The age and gender-adjusted cancer risk was calculated following Monte Carlo code,according to Biological Effects of Ionizing Radiation (BEIR VII) empirical risk models.

Results
The estimated additional cancer risk throughout life gained with a single ablation procedure was significatively different between groups:0.18% in CFA compared to 0.001% in MFA group(P &lt; 0.001).The maximum estimated additional cancer risk for a patient undergoing CFA was 1%.10 out of 29 MFA procedures(35%)were successfully performed with zero fluoroscopy. Conclusions:Our small study demonstrates that an echocardiography/EAM guided approach allows safe AP ablation adding a significantly reduced estimated cancer risk compared to CFA in young adults,a population sensitive to X-ray exposure regarding the stochastic risk of developing malignancies.This finding strongly supports the recommendation for a routine use of EAMS in AP ablations,including appropriate reimbursement.
Results Conventional fluoroscopic approach Minimal fluoroscopic approach p Patient (N) 31 29 n.s. Age (Y) 43.7 ± 14 44.7 ± 17 n.s. Right AP 10 6 n.s. Left Ap 21 23 n.s. Transeptal Access 20 22 n.s. Complications 1 (3%) 0 n.s. DAP (µGy*m2) 15252+/-11132 56.8+/-135.6 0.000 Effective Dose (mSv) 30.35+/-27.7 0.09+/-0.28 0.000. Additional Cancer Risk 0.18% 0.001% &gt;0.001 N, number; Y, years; AP, Accessory Pathway.
P539Comparative analysis of patients with cardiac resynchronization therapy depending on septal flash
Authors: Shirokov N , Kuznetsov V , Soldatova A , Malishevskii L , Krinochkin D 
Published: June 2020

Abstract

Background
Mechanical dyssynchrony (MD) and superresponse (SR) to cardiac resynchronisation therapy (CRT) relationship is still debated.

Aim
To assess clinical and morpho-functional features of the heart in patients with congestive heart failure (CHF) after cardiac resynchronization therapy (CRT) depending on septal flash (SF).

Materials and methods
The study enrolled 60 patients (92.0% men, 8.0% women; mean age 54.5 ± 10.4 years; 70.0% had left bundle branch block (LBBB) with II-IV NYHA functional class CHF. SF (mechanical anomaly of interventricular septum (IVS) movement) is determined according to speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI). Patients were divided into two groups: with SF (I group, n = 10) and without SF (II group, n = 50).

Results
At baseline the groups did not differ in main clinical characteristics including QRS width and LBBB. Mechanical interventricular delay was higher in group I (65.5 ms [53.5;95.5] vs 31.0 ms [15.0;64.5]; р=0.026). Basal segment of IVS longitudinal strain (LS) delay by STE (257.5 ms [156.3;293.8] vs 323.5 ms [262.5;377.8]; р=0.024) and LS delay by TDI (204.0 ms [170.8;260.3] vs 434.0 ms [370.0;489.0]; р&lt;0.001) were significantly lower in group with SF. According to logistic regression a combination of LS apical segment of IVS by STE (HR 0.607; 95% Cl 0.369 – 0.989; р=0,048) and LS delay basal segment of IVS by TDI (HR 0.969; 95% Cl 0.0945 – 0.993; р=0.011) had a relationship with SF. According to ROC analysis sensitivity and specificity of this model in SF definition in patients with CRT were 87.5% and 86.5% (AUC = 0.939; p &lt; 0.01). Mean changes in LV ESV (52.0 ml [32.5;72.8] vs 19,0 ml [1.3;40.0]; р=0.002) and LV ejection fraction (EF) (13.0% [5.5;18.8] vs 4.0% [2.0;9.0]; р=0.002) were significantly higher in patients with SF. All patients in group I had a super-response to CRT (ESV LV decrease ≥30%); 42.0% patients in group II were superresponders (р&lt;0.001).

Conclusion
SF could be determined by STE and TDI. SF is associated with severe mechanical interventricular dyssynchrony and superresponse to CRT. Patients with SF have significantly better LV EF dynamics after CRT.
Abstract Figure. Septal Flash in patient with SR to CRT