bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study of the preliminary efficacy of Pain Buddy: A novel intervention for the management of children's cancer‐related pain
Authors: Hunter John F. , Acevedo Amanda M. , Gago‐Masague Sergio , Kain Alexandra , Yun Christine , Torno Lilibeth , Jenkins Brooke N. , Fortier Michelle A. 
Published: August 2020

AbstractObjectivesCancer‐related pain in children is prevalent and undermanaged. Mobile health (mHealth) applications provide a promising avenue to address the gap in pain management in children with cancer. Pain Buddy is a multicomponent mHealth application developed to manage cancer‐related pain in children. The goal of this paper is to present preliminary efficacy data of the impact of Pain Buddy on children's pain severity and frequency.MethodsIn a randomized controlled trial over 60 days, children (N = 48) reported daily pain on a tablet while receiving usual care. Those in the intervention group (N = 20) received remote symptom monitoring and skills training for pain management. Children in the attention control group (N = 28) only reported on their pain.ResultsBoth groups experienced significant reductions in average daily pain over the study period (B = −0.10, z = −3.40, P = 0.001), with no group differences evident (z = −0.83, P = 0.40). However, the intervention group reported significantly fewer instances of moderate to severe pain compared with the control group, t(4125) = 2.67, P = 0.007. In addition, the intervention group reported no instances of moderate to severe pain toward the end of the study period.ConclusionPain Buddy is an innovative and interactive mHealth application that aims to improve pain and symptom management among children with cancer. The findings from this pilot study suggest that Pain Buddy may aid in the reduction of pain severity in children during cancer treatment.
Laser Forensics: The Invisible – Revealed and Measured
Authors: Kern Sven 
Published: August 2020

AbstractAccording to the developers at Scanovis – a start‐up company based in Koblenz – brushes, powder and chemicals will soon be tools of the past for securing evidence at crime scenes. The company has developed a laser‐based solution that, among other things, uses IR laser radiation to detect fingerprints at the scene of a crime, quickly making them visible in a 3D scan and recording them digitally. Decisive factors for this technological breakthrough are the precision of the results delivered by the laser scanner and the easy handling of the system. But how to adjust the optics of a system using a low power laser in the mid‐infrared spectrum (MIR)? Working together with Ophir's measurement experts, the company was able to combine different measurement methods to this end.
Designing historical control studies with survival endpoints using exact statistical inference
Authors: Han Gang 
Published: August 2020

SummaryHistorical control trials compare an experimental treatment with a previously conducted control treatment. By assigning all recruited samples to the experimental arm, historical control trials can better identify promising treatments in early phase trials compared with randomized control trials. Existing designs of historical control trials with survival endpoints are based on asymptotic normal distribution. However, it remains unclear whether the asymptotic distribution of the test statistic is close enough to the true distribution given relatively small sample sizes in early phase trials. In this article, we address this question by introducing an exact design approach for exponentially distributed survival endpoints, and compare it with an asymptotic design in both real examples and simulation examples. Simulation results show that the asymptotic test could lead to bias in the sample size estimation. We conclude the proposed exact design should be used in the design of historical control trials.
Consensus building in linguistic failure mode and effect analysis: A perspective based on prospect theory
Authors: Fan Chuanhao , Zhu Yan , Li Wei , Zhang Hengjie 
Published: August 2020

AbstractAs one of many scientific and efficient risk assessment approaches, failure mode and effect analysis (FMEA) has been widely applied across various fields. There are two core issues in the FMEA approach: identifying the latent failure modes of the systems, products, processes and services and the risk assessment and the prioritization of those failure modes. Then, corrective measures must be taken in a timely and accessible manner to prevent the occurrence of failure modes with higher risk levels. In practice, several FMEA members from different fields are usually involved in the FMEA implementation process; the risk assessment information given by them may vary greatly. Therefore, it is necessary to integrate a consensus‐building process into FMEA. Meanwhile, the psychological behaviours of FMEA members have had a great impact on the final prioritization of failure modes. Prospect theory is an effective approach for describing individual psychological behaviours. Therefore, this paper presents a novel linguistic FMEA approach to address the consensus issue from the perspective of prospect theory. In the proposed linguistic FMEA approach, a consensus measurement approach based on prospect theory is constructed. Then, a novel feedback adjustment mechanism is designed in which FMEA members can adjust not only their assessment information but also their reference points to achieve an acceptable consensus degree. Eventually, a practical application is used to show the validity and applicability of the proposed linguistic FMEA approach.
Software process selection system based on multicriteria decision making
Authors: Pandey Prateek , Litoriya Ratnesh 
Published: August 2020

AbstractWhatever be the nature of underlying software, the impact of the software development process that was used to create it would remain vital. The objective of this paper is to provide a process selection framework for the software development firm's engineers and managers, looking to identify the proper way to build software to run on a mobile, web, or desktop. The motivation behind this work comes from the fact that the applications that fall in one of the above three categories can be significantly different in terms of scale, UI, and memory requirements, time to market, and other characteristics. Software development that needs to be completed in a challenging timeframe has to resort to principles and values as declared in Agile Manifesto. The availability of various agile methodologies has made the project managers often stuck when selecting the most suitable one. The proposed agile process identification system addresses this dilemma of engineering fraternity using a fuzzy variant of a popular multiple‐criteria decision‐making (MCDM) technique called the analytic hierarchy process (AHP). The proposed system is validated through a primary dataset generated as a result of the development of 20 software projects. The results are encouraging enough with a probability of true identification close to 88%.
Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population
Authors: Walsh Patrick , Truong Vincent , Nayak Sushmita , Saldías Montivero Marietta , Low Walter C. , Parr Ann M. , Dutton James R. 
Published: August 2020

AbstractDifferentiation of human pluripotent stem cells (hPSCs) into ectoderm provides neurons and glia useful for research, disease modeling, drug discovery, and potential cell therapies. In current protocols, hPSCs are traditionally differentiated into an obligate rostro-dorsal ectodermal fate expressing PAX6 after 6 to 12 days in vitro when protected from mesendoderm inducers. This rate-limiting step has performed a long-standing role in hindering the development of rapid differentiation protocols for ectoderm-derived cell types, as any protocol requires 6 to 10 days in vitro to simply initiate. Here, we report efficient differentiation of hPSCs into a naive early ectodermal intermediate within 24 hours using combined inhibition of bone morphogenic protein and fibroblast growth factor signaling. The induced population responds immediately to morphogen gradients to upregulate rostro-caudal neurodevelopmental landmark gene expression in a generally accelerated fashion. This method can serve as a new platform for the development of novel, rapid, and efficient protocols for the manufacture of hPSC-derived neural lineages.
Will “social distancing” lead to future “research distancing”: A reflection on COVID‐19 impacts on Alzheimer's disease research
Authors: Bardach Shoshana H. , Gibson Allison K. , Rhodus Elizabeth K. , Jicha Gregory A. 
Published: August 2020

AbstractCoronavirus disease 19 (COVID‐19) has dramatically altered everyday life, including the field of Alzheimer's disease (AD) research. This perspective article explores some of the ways in which COVID‐19 has already impacted the field, anticipates some of the long‐lasting effects, and explores strategies for addressing current and future needs. Areas of impact include study integrity, regulatory and industry issues, and participant engagement. Proposed strategies for addressing these challenges include analytic methods to deal with large degrees of missing data and development of patient‐centered, user‐friendly, remote data collection tools and assessments. We also highlight the importance of maintaining participant well‐being as a first and constant priority.
Two dimensional ferroelectrics: Candidate for controllable physical and chemical applications
Authors: Shang Jing , Tang Xiao , Kou Liangzhi 
Published: August 2020

AbstractThe recent emerged two‐dimensional (2D) ferroelectrics have attracted tremendous research interests due to their promising application in nonvolatile electronics devices. The reversible electric polarization of ferroelectrics from the off‐centered positive and negative surfaces can effectively lift the band states near Fermi level and modulate the charge distribution, which therefore play important roles for the controllable electronic/magnetic properties and chemical reactions. Here, based on the latest revealed 2D ferroelectrics, we reviewed the research progress of ferroelectric controlled physical properties and chemical reactions, including the effects of reversible polarization on magnetic and electronic behaviors, polarization dependent photocatalytic water splitting and gas adsorptions. The associated applications in electronics, sensors and energy conversion are also discussed. At last, the possible research directions of 2D ferroelectrics have also been proposed. The review is expected to inspire the research interests of 2D ferroelectrics in the practical applications.This article is categorized under:
Structure and Mechanism > Computational Materials Science
Electronic Structure Theory > Density Functional Theory
Fetal programming effects of pentaerythritol tetranitrate in a rat model of superimposed preeclampsia
Authors: Man Andy W. C. , Chen Min , Zhou Yawen , Wu Zhixiong , Reifenberg Gisela , Daiber Andreas , Münzel Thomas , Xia Ning , Li Huige 
Published: August 2020

Abstract
Preeclampsia is a common medical condition during pregnancy and a major cause of maternal and prenatal mortality. The present study was conducted to investigate the effects of maternal treatment with pentaerythritol tetranitrate (PETN) in Dahl salt-sensitive rats (DSSR), a model of superimposed preeclampsia. F0 parental DSSR were treated with PETN (50 mg/kg) from the time point of mating to the end of lactation. Maternal PETN treatment improved fetal growth and had no effect on blood pressure in DSSR offspring fed with normal chow or high-salt diet. Upon high-fat diet (HFD) feeding, offspring from PETN-treated mother showed improved glucose tolerance despite similar weight gain. Unexpectedly, maternal PETN treatment significantly potentiated the HFD-induced blood pressure elevation in male DSSR offspring. Endothelium-derived hyperpolarization factor (EDHF)-mediated vasodilation was similar between NCD-fed and HFD-fed control offspring but was markedly reduced in HFD-fed PETN offspring. EDHF genes were downregulated in the vasculature of HFD-fed PETN offspring, which was associated with epigenetic changes in histone modifications. In conclusion, maternal PETN treatment in DSSR shows both beneficial and unfavorable effects. It improves fetal growth and ameliorates glucose tolerance in the offspring. Although maternal PETN treatment has no effect on blood pressure in offspring fed with normal chow or high-salt diet, the offspring is at higher risk to develop HFD-induced hypertension. PETN may potentiate the blood pressure response to HFD by epigenetic modifications of EDHF genes.

Key messages
The core findings of this article suggest that maternal PETN treatment of DSSR, a rat model of a spontaneous superimposed preeclampsia, leads to
• Improvement of fetal growth;
• No changes of maternal blood pressure or markers of preeclampsia;
• Amelioration of HFD-induced glucose intolerance in adult offspring;
• No changes in blood pressure development of the offspring on normal chow or high salt-diet;
• Potentiation of blood pressure elevation of the offspring on HFD.
Metoprolol blunts the time-dependent progression of infarct size
Authors: Lobo-Gonzalez Manuel , Galán-Arriola Carlos , Rossello Xavier , González‐Del‐Hoyo Maribel , Vilchez Jean Paul , Higuero-Verdejo María I. , García-Ruiz Jose M. , López-Martín Gonzalo J. , Sánchez-González Javier , Oliver Eduardo , Pizarro Gonzalo , Fuster Valentin , Ibanez Borja 
Published: August 2020

AbstractEarly metoprolol administration protects against myocardial ischemia–reperfusion injury, but its effect on infarct size progression (ischemic injury) is unknown. Eight groups of pigs (total n = 122) underwent coronary artery occlusion of varying duration (20, 25, 30, 35, 40, 45, 50, or 60 min) followed by reperfusion. In each group, pigs were randomized to i.v. metoprolol (0.75 mg/kg) or vehicle (saline) 20 min after ischemia onset. The primary outcome measure was infarct size (IS) on day7 cardiac magnetic resonance (CMR) normalized to area at risk (AAR, measured by perfusion computed tomography [CT] during ischemia). Metoprolol treatment reduced overall mortality (10% vs 26%, p = 0.03) and the incidence and number of primary ventricular fibrillations during infarct induction. In controls, IS after 20-min ischemia was ≈ 5% of the area AAR. Thereafter, IS progressed exponentially, occupying almost all the AAR after 35 min of ischemia. Metoprolol injection significantly reduced the slope of IS progression (p = 0.004 for final IS). Head-to-head comparison (metoprolol treated vs vehicle treated) showed statistically significant reductions in IS at 30, 35, 40, and 50-min reperfusion. At 60-min reperfusion, IS was 100% of AAR in both groups. Despite more prolonged ischemia, metoprolol-treated pigs reperfused at 50 min had smaller infarcts than control pigs undergoing ischemia for 40 or 45 min and similar-sized infarcts to those undergoing 35-min ischemia. Day-45 LVEF was higher in metoprolol-treated vs vehicle-treated pigs (41.6% vs 36.5%, p = 0.008). In summary, metoprolol administration early during ischemia attenuates IS progression and reduces the incidence of primary ventricular fibrillation. These data identify metoprolol as an intervention ideally suited to the treatment of STEMI patients identified early in the course of infarction and requiring long transport times before primary angioplasty.
Automated detection of electrically evoked stapedius reflexes (eSR) during cochlear implantation
Authors: Weiss Nora M. , Óvári Attila , Oberhoffner Tobias , Demaret Laurent , Bicer Atabek , Schraven Sebastian , Ehrt Karsten , Dahl Rüdiger , Schneider Armin , Mlynski Robert 
Published: August 2020

Abstract
Introduction
In cochlear implantation, objective fitting methods are needed to optimize audiological results in small children or patients with poor compliance. Intraoperatively measured electrically evoked stapedius reflexes (eSR) can be used as a marker for the patient’s discomfort level. The aim of this study was to develop and evaluate an automated detection method for eSR and to compare it to the detection rate of the surgeon and independent observers.

Methods
Cochlear implantation using a fully digital surgical microscope was performed. Movements of the stapedius tendon were recorded and analyzed by means of computer vision technique. Differences in eSR elicited by stimulating electrodes at different cochlear locations (basal, middle and apical) were analyzed. The eSR detection rate of the image processing algorithm was compared to the surgeon’s detection rate and to those of two less experienced observers.

Results
A total of 387 electrically impulses were applied. The stimulation of middle turn electrodes showed significantly higher detection rates (50.4%) compared to the basal (40.0%; p = 0.001) and apical (43.6%; p = 0.03) turn. The software identified significantly more of the applied stimuli (58.4%) compared to the surgeon (46.3%; p = 0.0007), the intermediate observer (37.7%; p < 0.0001) and the unexperienced observer (41.3%; p < 0.0001).

Conclusion
The feasibility of an automated intraoperative software-based detection of eSR is demonstrated. By improving the eSR detection methods and their clinical applicability, their utility in objective cochlear implant fitting may be substantially increased.
Babylonian observations of a unique planetary configuration
Authors: de Jong Teije , Hunger Hermann 
Published: August 2020

AbstractIn this paper, we discuss Babylonian observations of a “massing of the planets” reported in two Astronomical Diaries, BM 32562 and BM 46051. This extremely rare astronomical phenomenon was observed in Babylon between 20 and 30 March 185 BC shortly before sunrise when all five planets were simultaneously visible for about 10 to 15 min close to the horizon in the eastern morning sky. These two observational texts are not only interesting as records of an extremely rare planetary configuration, but also because (1) the observers appear to be confused by the presence of all planets simultaneously and mix them up in their reports, and (2) the two reports of the same observations are so different that we are forced to conclude that they were carried out by two different observers. There is an additional astronomical event which makes this planetary configuration even more unique: the exact conjunction of the planets Mars and Jupiter in the afternoon of 25 March 185 BC. An exact conjunction, where two planets are so close together that they appear as one object in the sky, is also extremely rare. Although this exact conjunction between Mars and Jupiter occurred during the day so that it was not observable, it was correctly predicted by the Babylonian scholars: a remarkable achievement and a nice illustration of their astronomical craftsmanship. Finally, our study clearly exposes one of the limitations of Babylonian naked-eye astronomy. When first appearances of the planets Mercury, Mars and Saturn are expected around the same date, it is nearly impossible to correctly identify them because their expected positions are only approximately known while they have about the same visual magnitude so that they become visible at about the same altitude above the horizon.
Characterization of Naturally Occurring Radioactive Material (NORM) Generated from the Lower Cretaceous Carbonate Formations in the Arabian Peninsula and Gulf
Authors: Arneodo Francesco , Balata Marco , Benabderrahmane Mohamed Lotfi , Bruno Gianmarco , Di Giovanni Adriano , Fawwaz Osama , Laubenstein Matthias , Manenti Laura , Nisi Stefano , Richter Rüdiger B. 
Published: August 2020

AbstractFor most of the petroleum reservoirs in the world, the impact of the mother nuclides such as uranium-238 on the deposition of radioactive materials a.k.a. NORM from the formation and particularly as mineral scales adherent to tubulars and other equipment is considered insignificant. Uranium is regarded as insoluble in the reservoir formation and the prevailing understanding is that dissolved radium is not generated necessarily by U and Th in solution. Consequently, “uranium scale”, as a technical term, seems to be non-existent in the oil and gas industry. However, gamma spectroscopy and chemical analysis of NORM scale samples of carbonate origin, performed in the course of this research, has proven that they actually can contain uranium. A fundamental relationship between uranium and vanadium in scales is presumed. The highest specific activity of 238U in scale analyzed with gamma spectroscopy was at 11.4 [Bq/g] and supplementary chemical analysis has shown concentrations of up to 740 ppm total uranium and up to 260 ppm vanadium.
An evaluation of three DoE-guided meta-heuristic-based solution methods for a three-echelon sustainable distribution network
Authors: Validi Sahar , Bhattacharya Arijit , Byrne P. J. 
Published: August 2020

AbstractThis article evaluates the efficiency of three meta-heuristic optimiser (viz. MOGA-II, MOPSO and NSGA-II)-based solution methods for designing a sustainable three-echelon distribution network. The distribution network employs a bi-objective location-routing model. Due to the mathematically NP-hard nature of the model a multi-disciplinary optimisation commercial platform, modeFRONTIER®, is adopted to utilise the solution methods. The proposed Design of Experiment (DoE)-guided solution methods are of two phased that solve the NP-hard model to attain minimal total costs and total CO2 emission from transportation. Convergence of the optimisers are tested and compared. Ranking of the realistic results are examined using Pareto frontiers and the Technique for Order Preference by Similarity to Ideal Solution approach, followed by determination of the optimal transportation routes. A case of an Irish dairy processing industry’s three-echelon logistics network is considered to validate the solution methods. The results obtained through the proposed methods provide information on open/closed distribution centres (DCs), vehicle routing patterns connecting plants to DCs, open DCs to retailers and retailers to retailers, and number of trucks required in each route to transport the products. It is found that the DoE-guided NSGA-II optimiser based solution is more efficient when compared with the DoE-guided MOGA-II and MOPSO optimiser based solution methods in solving the bi-objective NP-hard three-echelon sustainable model. This efficient solution method enable managers to structure the physical distribution network on the demand side of a logistics network, minimising total cost and total CO2 emission from transportation while satisfying all operational constraints.
Drama and Discounting in the Relational Dynamics of Corporate Social Responsibility
Authors: Grigore Georgiana , Molesworth Mike , Vonțea Andreea , Basnawi Abdullah Hasan , Celep Ogeday , Jesudoss Sylvian Patrick 
Published: August 2020

AbstractEmploying theoretical resources from Transactional Analysis (TA) and drawing from interviews with managers dealing with social or environmental issues in their role, we explain how CSR activity provides a context for dramas in which actors may ignore, or discount aspects of self, others, and the contexts of their work as they maintain and reproduce the roles of Rescuers, Persecutors and Victims. In doing so, we add to knowledge about CSR by providing an explanation for how the contradictions of CSR are avoided in practice even when actors may be aware of them. Specifically, we theorise how CSR work can produce dramatic stories where adversity is apparently overcome, whilst little is actually achieved at the social level. We also add to the range of psychoanalytic tools used to account for organisational behaviours, emphasising how TA can explain the relational dynamics of CSR.