bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epileptic seizures triggered by eating in dogs
Authors: Brocal Josep , Lowrie Mark , Wamsley Gemma , Cauduro Alberto , Mandigers Paul , Gutierrez‐Quintana Rodrigo , Stalin Catherine 
Published: April 2020

AbstractBackgroundSeizures triggered by eating (STE) behavior are very rare in humans and have not been documented previously in dogs.ObjectivesTo document the occurrence of STE in dogs and describe their clinical features.AnimalsTen client‐owned dogs with STE diagnosed at 5 European referral centers.MethodsA call for suspected cases of STE was made online. This call was followed by a retrospective review of medical records, combined with a questionnaire to be completed by both the owner and the board‐certified neurologist who made the diagnosis. Cases were included if >50% of the seizures that occurred were related to eating and if a minimum diagnostic evaluation for seizures had been performed.ResultsFour cases only had STE and 6 cases had both STE and spontaneous seizures. Four of the dogs were retrievers. The most common seizure type was focal epileptic seizures evolving to become generalized. Nine dogs were diagnosed with idiopathic epilepsy. One dog had a presumptive diagnosis of glioma involving the margins of the parietal, temporal, and frontal cortex (the perisylvian region), an area known to have a key role in eating‐associated epilepsy in people. Treatment strategies included a combination of pharmacological management and eating habit changes.Conclusions and Clinical ImportanceWe have identified a form of reflex epilepsy in dogs, with STE behavior. Further studies are warranted to improve the characterization and management of STE.
How do urinary incontinence types affect sexual function and quality of life for Turkish women?
Authors: Bilgic Dilek , Kizilkaya Beji Nezihe 
Published: April 2020

AbstractObjectiveUrinary incontinence (UI) subtypes may have some effects on sexual function because of diverse pathophysiological mechanisms. The objective of our study is to compare UI subtypes’ effects on women's sexual function and quality of life (QoL).MethodsIn this descriptive and comparative study, a total of 239 women with UI were included (89 with stress urinary incontinence [SUI], 65 with urge urinary incontinence [UUI], and 85 with mixed urinary incontinence [MUI]). Sexual function was assessed with the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ‐12), and QoL was assessed with the Incontinence Impact Questionnaire‐7 (IIQ‐7).ResultsIn our study, the mean total PISQ‐12 score for the UI subtypes was 29.49 ± 6.38 for SUI, 31.43 ± 5.46 for UUI, and 23.12 ± 5.54 for MUI. Women with MUI had significantly more sexual dysfunctions than the other groups (P < .001). The mean total IIQ‐7 score according to UI subtypes was 60.61 ± 31.49 for SUI, 64.40 ± 28.20 for UUI, and 70.51 ± 25.09 for MUI. As regards the scores of the IIQ‐7, UI had a negative impact on QoL for women of all groups, especially for women with MUI and UUI, but was not significantly different between the groups (P > .05).ConclusionThe sexual function of women with MUI was affected more adversely than the other UI subtypes. There was no statistically significant difference between the UI subtypes according to IIQ‐7 scores, but when we examined the scores, MUI and UUI were found to have more negative effects on QoL. Clinicians and continence nurses should make routine evaluations of sexual function and QoL for women according to UI subtypes.
STOICISM AND ITS TELOS
Authors: Weiss Robin 
Published: April 2020

AbstractThis essay concerns the disputed nature of the telos in Stoicism and argues that Michel Foucault’s description of the Stoic telos plausibly constitutes an accurate characterization, despite the frequent criticism it has received and the fact that it apparently neglects the important role of nature or physics in Stoicism. To advance this claim, the essay draws upon a neglected set of observations made by Foucault inThe Hermeneutics of the Subject, in which the telos is characterized in terms of the elimination ofstultitia, or “indecision.” Once we analyze indecision and its causes from the perspective of physics, we can see that indecision is incompatible with the Stoic telos as standardly described, for example as “life in accord with nature.” It can be concluded that the Foucault’s view is not only plausible but is in fact supported by Stoic physics. The essay concludes with a discussion of some possible objections.
Novel CAPN3 variant associated with an autosomal dominant calpainopathy
Authors: Cerino M. , Campana‐Salort E. , Salvi A. , Cintas P. , Renard D. , Juntas Morales R. , Tard C. , Leturcq F. , Stojkovic T. , Bonello‐Palot N. , Gorokhova S. , Mortreux J. , Maues De Paula A. , Lévy N. , Pouget J. , Cossée M. , Bartoli M. , Krahn M. , Attarian S. 
Published: April 2020

AimsThe most common autosomal recessive limb girdle muscular dystrophy is associated with the CAPN3 gene. The exclusively recessive inheritance of this disorder has been recently challenged by the description of the recurrent variants, c.643_663del21 [p.(Ser215_Gly221del)] and c.598_612del15 [p.(Phe200_Leu204del)], associated with autosomal dominant inheritance. Our objective was to confirm the existence of autosomal dominant calpainopathies.MethodsThrough our activity as one of the reference centres for genetic diagnosis of calpainopathies in France and the resulting collaborations through the French National Network for Rare Neuromuscular Diseases (FILNEMUS), we identified four families harbouring the same CAPN3 heterozygous variant with supposedly autosomal dominant inheritance.ResultsWe identified a novel dominantly inherited CAPN3 variant, c.1333G>A [p.(Gly445Arg)] in 14 affected patients from four unrelated families. The complementary phenotypic, functional and genetic findings correlate with an autosomal dominant inheritance in these families, emphasizing the existence of this novel transmission mode for calpainopathies. The mild phenotype associated with these autosomal dominant cases widens the phenotypic spectrum of calpainopathies and should therefore be considered in clinical practice.ConclusionsWe confirm the existence of autosomal dominant calpainopathies as an entity beyond the cases related to the in‐frame deletions c.643_663del21 and c.598_612del15, with the identification of a novel dominantly inherited and well‐documented CAPN3 missense variant, c.1333G>A [p.(Gly445Arg)]. In addition to the consequences for genetic counselling, the confirmation of an autosomal dominant transmission mode for calpainopathies underlines the importance of re‐assessing other myopathies for which the inheritance is considered as strictly autosomal recessive.
Utility of the QTA30 in a school medical checkup for adolescent students
Authors: Habukawa Chizu , Nagamitsu Shinichiro , Koyanagi Kenshi , Nishikii Yumi , Yanagimoto Yoshitoki , Yoshida Seiji , Suzuki Yuichi , Go Soken , Murakami Katsumi 
Published: April 2020

AbstractBackgroundIn adolescence, physical symptoms may develop due to psychosocial problems, but such problems are not fully evaluated in school medical checkups. The aim of the study was to compare the characteristics of students with high and low scores on the Questionnaire for Triage and Assessment with 30 items (QTA30) in a school health checkup.MethodsThe QTA30 (a self‐completed questionnaire) was used in checkups for 3,414 students from the 5th grade of primary schools to the 3rd grade of junior high schools in south Wakayama Prefecture. The students were divided into groups with high (QTA30 ≥ 37) and low (QTA30 < 37) risk for psychosomatic disorder. Eleven items, including gender, grade, lifestyle habits, and life events, were compared between these groups, and in subgroups with and without recent absence from school.ResultsThe QTA30 response rate was 87.9%. The high‐risk group had significantly more 3rd grade students (P< 0.001), females (P< 0.001), problems with teachers or friends (P< 0.001), and experience of bullying (P< 0.001), in addition to game playing for ≥2 h (P< 0.001), late bedtime (P< 0.001), and many absences (P< 0.001). Students in the high‐risk group with no absences for 1 month regardless of age still had a late bedtime and problems with friends, and 76.4% of the high‐risk students had not visited a medical institution.ConclusionsUse of the QTA30 facilitated detection of psychosomatic stress in school medical checkups, with latent risks of truancy detectable at an early phase. The QTA30 may thus be useful in early intervention for psychosomatic stress of adolescents.
Does business influence government regulations? New evidence from Canadian impact assessments
Authors: Beaulieu‐Guay Louis‐Robert , Tremblay‐Faulkner Marc , Montpetit Éric 
Published: April 2020

AbstractRegulatory impact assessments frequently embed stakeholder consultations in their design. Canada was one of the early adopters of such an approach and therefore has systematic documentation on the actors taking part in these consultations. This article asks whether these consultations have an influence on regulatory change and whether business disproportionally benefits from them. After converting the documentation into data, we find that these consultations do in fact matter: the more diversified the stakeholders taking part, the more stringent the changed regulations. But we also found that for a subset of regulatory changes, those likely to carry high economic stakes, business takes advantage of the consultation, often obtaining some reduction in regulatory stringency. These reductions, however, are conditioned on the limited presence of opposing views expressed during the consultations.
Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus
Authors: Levy Britt J. , Linder Keith E. , Mamo Lisa B. , Herrmann Ina , Bizikova Petra 
Published: April 2020

BackgroundPolyautoimmunity, the concurrent expression of two or more distinct autoimmune diseases (ADs) in a single individual, is a known phenomenon in humans and has been rarely reported in dogs. To the best of the authors’ knowledge, comorbid pemphigus foliaceus (PF) and generalized discoid lupus erythematosus (GDLE) has not been reported in dogs.Hypothesis/ObjectivesTo describe the clinical, histological and immunological features and treatment outcome of two unrelated dogs with comorbid PF and GDLE.AnimalsOne 10‐year‐old, spayed German shepherd dog and one 8‐year‐old, castrated American Staffordshire terrier presented for evaluation of a symmetrical, facial‐ and/or pedal‐dominant pustular dermatitis with concurrent, truncal scaly plaques.MethodsFor each dog, clinicopathological characterization included physical examination, lesion cytological evaluation, bacterial culture and sensitivity testing, skin histopathological investigation and direct and indirect immunofluorescence testing. Additional diagnostic imaging and haematological testing was performed to exclude extracutaneous disease.ResultsBoth dogs exhibited lesions clinically and histologically compatible with PF and GDLE. Moreover, one dog exhibited generalized leucotrichia and chronic superficial keratitis. Remission was achieved with immunosuppressive dosages of prednisolone [high‐dose pulse (Case 1) or standard immunosuppressive dosage (Case 2)] and ciclosporin (5–6 mg/kg/day). Tissue‐bound antikeratinocyte immunoglobulin (Ig)G and IgM were detected in both dogs. A weak basement membrane zone deposit of C3 was seen in one dog. Circulating antikeratinocyte and anti‐desmocollin‐1 IgG were detected in one dog.Conclusions and clinical importanceCutaneous polyautoimmunity can occur in the dog. Depending on the specific disease combinations, overlapping clinical features may present diagnostic and/or therapeutic challenges. Moreover, these cases should be monitored for development of additional cutaneous or extra‐cutaneous AD(s).
Effect of hydraulic residence time and inlet flow distribution ratio on the pollutant removal of low‐temperature municipal wastewater in multistage AO process
Authors: Wang Fan , Li Jun , Bian Dejun , Nie Zebing , Ai Shengshu , Tian Xi , Wang Hongliang 
Published: April 2020

AbstractLow temperature environment was one of the difficulties in sewage treatment. In this study, the removal efficiency of multistage AO process was analysed under different hydraulic residence time (12 h, 8 h and 6 h) and inlet flow distribution ratio(5 : 4 : 4, 3 : 2 : 1 and 25 : 15 : 6), the rules of pollutant migration and transformation were compared and analysed under different control parameters. The results show that enhanced nitrogen removal and optimised organics utilisation were obtained simultaneously in the feeding process with hydraulic retention time of 8 h as well as influent distribution ratio of 3 : 2 : 1. HRT and inlet flow distribution ratio affect nitrogen load and organic matter distribution in each stage of the multistage AO system, the removal efficiency of ammonia nitrogen in each stage of the system was more than 80% under optimal conditions, the total nitrogen removal rate was more than 80%, among which the synchronous nitrification and denitrification account for 29.50%.
Peridynamics for Heat Conduction
Authors: Mikata Yozo 
Published: April 2020

Abstract
Peridynamics for transient heat conduction problems in general anisotropic materials is developed. In order to develop a new peridynamic governing equation for heat conduction problems, the microconductivity (or microdiffusivity), which contains equivalent information as the constitutive equation for classical heat conduction, is determined by directly requiring the resulting peridynamic equation to converge to a classical heat conduction equation for anisotropic materials as the generalized material horizon approaches zero. Therefore, the convergence proof is built into the theory from the perspective of the governing equation. For the application of the newly obtained peridynamic governing equation, a time-dependent three-dimensional (3D) peridynamic heat equation is analytically solved with two types of heat sources, and the results are discussed. These are believed to be the first exact analytical solutions for peridynamic heat conduction.
Climate-driven late Quaternary fan surface abandonment in the NW Himalaya
Authors: Orr* Elizabeth N. , Owen* Lewis A. , Saha* Sourav , Caffee* Marc W. 
Published: April 2020

ABSTRACT
We defined the timing of surface abandonment for 10 alluvial and debris-flow fans across contrasting climatic settings in the NW Himalaya of northern India using cosmogenic 10Be surface exposure dating. Debris-flow fans in the Garhwal, Kullu, and Lahul-Spiti regions of the monsoon-influenced Greater Himalaya were largely abandoned during the Mid- to Late Holocene. Large alluvial fans and smaller debris-flow fans in the semiarid Ladakh region of the Greater and Tethyan Himalaya have surface ages that extend throughout the last glacial. Regional events of landform abandonment and incision were defined for the monsoon-influenced western Himalaya ranges and the semiarid western Himalaya ranges over the past ~120 k.y. In the monsoon-influenced and semiarid western Himalaya ranges, these regional events were limited to the Holocene and from ca. 40 ka, respectively. The timing of fan surface abandonment and regional landform abandonment events coincided with periods of weakening monsoon strength and cooling, and local and regional glacier advances. Regional incision events from the monsoon-influenced and semiarid western Himalaya regions were recognized across various climatic conditions due to the ubiquitous nature of erosion in mountain settings. This study showed that climate-driven processes and glaciation were important drivers in fan sedimentation, catchment sediment flux, and the topographic evolution of the NW Himalaya during the late Quaternary.
Multiple mechanisms of minor moraine formation in the Schwarzensteinkees foreland, Austria
Authors: Wyshnytzky Cianna E. , Lukas Sven , Groves John W.E. 
Published: April 2020

ABSTRACT
This paper presents a detailed sedimentologic data set of minor moraines (heights ≤2.0 m, widths ≤14 m, lengths ≤108 m) that formed beginning near the end of the Little Ice Age by Schwarzensteinkees, a valley glacier in Austria. Sorted sediment and stratified diamict dominate five exposures, and compact massive diamict exists in one exposure. This sediment is interpreted as proglacial outwash and subglacial till. Most moraine sediment shows deformation structures (e.g., smaller and larger folds), and some units contain evidence of water escape. Other units maintain their original subhorizontality. All moraines contain unequivocal evidence of having formed through deformation by pushing during ice-margin fluctuations. Minor moraines formed more specifically by three identified processes: (1) pushing of outwash sediment; (2) stacking and pushing of outwash sediment; and (3) pushing of outwash sediment and freezing-on of subglacial till. Our data suggest that the sedimentologic composition of the valley fill influences the style of push-moraine formation. In this case, the friable nature of outwash sediments can increase the efficiency of the pushing ice front and the likelihood of sediment collapse down the proximal ice-contact slope after ice retreat. This study contributes to our understanding of sediment transport and deposition in high-mountain environments.
Prescribing in the prehospital environment: a review of the pharmaceutical Module 501 on UK Military Exercise SAIF SAREEA 3. Can such analysis assist with the scaling of healthcare assets?
Authors: Davies L G , Thompson D C , Gillett R , Smith M B 
Published: April 2020

IntroductionModule 501 provides core medications which are fundamental to the capability of a prehospital treatment team (PHTT). The quantities of each medication in the module inventory undergo regular review, but these do not correspond to a population at risk (PAR) figure or deployment length for which they intend to be used. This article proposes how the quantities of Module 501 drugs can be scaled for a given deployment, in this example using statistics taken from static PHTTs on Exercise Saif Sareea 3 (SS3).MethodsThe statistics were gathered using a custom-built search of electronic records from the Deployed Defence Medical Information Capability Programme in addition to written record-keeping, which were aligned to the weekly PAR at each PHTT location throughout their full operational capability periods. A quotient was then derived for each module item using a formula.ResultsAmong the 10 most commonly prescribed drugs were four analgesics and three antimicrobials. 42 of the 110 studied drugs were not prescribed during SS3.DiscussionThe data from SS3 reflect the typical scope of disease encountered in the deployed land setting. Employing these data, the use of a formula to estimate the drug quantities needed to sustain a Strike Armoured Infantry Brigade over a 28-day period is demonstrated.RecommendationsFurther study of Module 501 across varied deployment environments would be valuable in evolving this approach to medicinal scaling if proven effective for the warm desert climate. It could then be applied to other modules to further inform future Strike medical planning.LimitationsSeveral considerations when drawing deductions from the data are mentioned, including the inaccuracy of predictor variables taken from the EpiNATO-2 reports.ConclusionThe proposed formula provides an evidence-based framework for scaling drug quantities for a deployment planning. This may improve patient safety and confer logistical, storage and fiscal benefits.
Paediatric critical illness associated with respiratory infection: a single-centre, retrospective cohort study
Authors: Alfaraidi Haifa , Luinstra Kathy , Eshaghi Alireza , Smieja Marek , Gubbay Jonathan B , Pernica Jeffrey M 
Published: April 2020

ObjectivesTo describe critically ill children with respiratory infections, classify them by infection syndrome type and determine the prevalence of Mycoplasma pneumoniae detection.Study designA retrospective, single-centre cohort study. All children aged 2 months–18 years with presumed respiratory infection who were admitted to a tertiary hospital paediatric intensive care unit (PICU) between September 2015 and October 2016 were eligible. Subjects were grouped by clinical syndrome (viral respiratory infection, asthma exacerbation, undifferentiated/uncomplicated pneumonia, pneumonia complicated by effusion/empyema and ‘other’). All subjects had nasopharyngeal swabs tested for respiratory viruses, M. pneumoniae and Chlamydia pneumoniae.ResultsThere were 221 subjects; the median age was 3.1 years; 44% were female; and 78% had medical comorbidities. The majority (75%) was treated with antibiotics, most often ceftriaxone (90% of treated children). Those with any pneumonia were significantly less likely to have a respiratory virus identified in their nasopharynges and had significantly higher C reactive protein (CRP) values than those in the viral infection and asthma groups. There were 10 subjects in whom M. pneumoniae was detected (4.5%, 95% CI 2.2% to 8.2%). Mycoplasma-positive children were older (difference 3.5 years, 95% CI 0.66 to 6.4 years) and had fewer viral coinfections (30% compared with 69%, p=0.02). The prevalence of Mycoplasma infection in children aged >5 years with any pneumonia was 13.2% (95%CI 4.4% to 28%).ConclusionsThe majority of participants had respiratory viruses detected and were treated with broad-spectrum antibiotics. Differences in CRP and viral prevalence were observed between children with different infection syndrome types. M. pneumoniae infection was not rare in school-aged children with pneumonia admitted to the PICU. Attention to antibiotic treatment and rapid diagnostic testing for Mycoplasma in older, critically ill children should be considered to optimise management and avert morbidity and mortality from respiratory infection.
Upper bound on the GUP parameter using the black hole shadow
Authors: Neves Juliano C. S. 
Published: April 2020

AbstractAn upper bound on the parameter that provides a generalized uncertainty principle (GUP) is obtained from the black hole shadow. With the aid of a recent constraint between regular black holes and the GUP parameter, it is indicated a relation between this parameter and the deviation from circularity of the black hole shadow. In the case of the recent announcement of the M87* results from the Event Horizon Telescope collaboration, a deviation from circularity $$\lesssim 10\%$$≲10% imposes a GUP parameter $$\beta _0 <10^{90}$$β0<1090.