bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroblasts Direct Differentiation of Human Breast Epithelial Progenitors
Authors: Morsing Mikkel , Kim Jiyoung , Villadsen René , Goldhammer Nadine , Jafari Abbas , Kassem Moustapha , Petersen Ole William , Ronnov-Jessen Lone 
Published: August 2020

Abstract
Background Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs consist of unique parenchymal entities embedded within a fibroblast-rich lobular stroma. Here, we establish and characterize a new human breast lobular fibroblast cell line against its interlobular counterpart with a view to assessing the role of region-specific stromal cues in the control of TDLU dynamics.Methods Primary lobular- and interlobular fibroblasts are transduced to express human telomerase reverse transcriptase (hTERT). Differentiation of the cell lines along lobular- and interlobular pathways is determined by immunocytochemical staining and genome-wide RNA sequencing. Their functional properties are further characterized by analysis of mesenchymal stem cell (MSC) differentiation repertoire in culture and in vivo . The cells´ physiological relevance for parenchymal differentiation is examined in heterotypic co-culture with fluorescence-activated cell sorting (FACS)-purified normal breast primary luminal- or myoepithelial progenitors. The co-cultures are immunostained for quantitative assessment of epithelial branching morphogenesis, polarization, growth and luminal epithelial maturation. In extension, myoepithelial progenitors are tested for luminal differentiation capacity in culture and in mouse xenografts. To unravel the significance of transforming growth factor-beta (TGF-β)-mediated crosstalk in TDLU-like morphogenesis and differentiation, fibroblasts are incubated with SB431542 prior to heterotypic co-culture with luminal cells.Results hTERT immortalized fibroblast cell lines retain critical phenotypic traits in culture and links to primary fibroblasts. Cell culture assays and transplantation to mice show that the origin of fibroblasts determines TDLU-like and ductal-like differentiation of epithelial progenitors. Whereas lobular fibroblasts support a high level of branching morphogenesis by luminal cells, interlobular fibroblasts support ductal-like myoepithelial characteristics. TDLU-like morphogenesis, at least in part, relies on intact TGF-β signaling. Conclusions The significance of the most prominent cell type in normal breast stroma, the fibroblast, in directing epithelial differentiation is largely unknown. Through establishment of lobular and interlobular fibroblast cell lines we here demonstrate that epithelial progenitors are submitted to stromal cues for site-specific differentiation. Our findings lend credence to considering stromal subtleties of crucial importance in the development of normal breast and, in turn, breast cancer.
Weather and Policy Influences on Mobility during the U.S. COVID-19 Pandemic
Authors: Wu Yihan , Mooring Todd , Linz Marianna 
Published: August 2020

Abstract
As the novel coronavirus SARS-CoV-2 continues to proliferate across the globe, it is a struggle to predict and prevent its spread. The successes of mobility interventions demonstrate how policies can help limit the person-to-person interactions that are essential to infection. With significant community spread, experts predict this virus will continue to be a threat until a safe and effective vaccine has been developed and widely deployed. We aim to understand mobility changes, measured via mobile device tracking, during the first major quarantine period in the United States by assessing how people changed their behavior in response to policies and to weather. Here we show that consistent national messaging was associated with consistent national behavioral change, regardless of local policy. Furthermore, while behavior changed with favorable weather conditions generally the changes did not increase encounters between people. The independence of encounters and temperatures suggests that behavioral changes will not impact any direct physical modulation of transmission by weather as the pandemic continues. Both of these results are encouraging for the potential of the country to be able to curb the virus with clear national messaging.
Combination anti-coronavirus therapies based on nonlinear mathematical models
Authors: González Jorge A. , Akhtar Z. , Andrews D. , Jimenez S. , Maldonado L. , Oceguera T. , Rondon Irving , Sotolongo-Costa O. 
Published: August 2020

Abstract
Using nonlinear mathematical models and experimental data from laboratory and clinical studies, we have designed new combination therapies against COVID-19
Crafting futures together: scenarios for water infrastructure asset management in a context of global change
Authors: Rulleau B. , Salles D. , Gilbert D. , Le Gat Y. , Renaud E. , Bernard P. , Gremmel J. , Giard A. , Assouan E. , de Grissac B. , Eisenbeis P. , Husson A. , Rambonilaza T. , Stricker A.-E. 
Published: August 2020

AbstractDrinking water supply networks play an essential role in protecting the human and economic wellbeing of the territories they serve. To ensure continued quality of service, organisations involved in water infrastructure asset management (WIAM) need to deal with a number of issues related to global change. This paper presents the results of an original interdisciplinary foresight approach carried out by a group of engineering and social scientists, in partnership with a number of stakeholders. The purpose was to examine various possible pathways for the future of a French territory. The full title of our foresight study is: ‘Supplying water destined for human consumption in Nouvelle-Aquitaine (France) up until 2070’. Four scenarios, as contrasted as possible, were designed based on five components: organisation and operation of the water supply service, social demands in terms of drinking water, the governance context, territorial dynamics, and the overall context. We then ran further simulations to visualise what a given infrastructure network would look like under each set of assumptions, and under different territorial configurations. One significant advantage of our foresight approach is the educational value it has for stakeholders and water managers. Foresight makes the future potentially visible and provides an opportunity to discuss it, in order to able to inform decision-making.
Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
Authors: Santarelli M.F. , Scipioni M. , Genovesi D. , Giorgetti A. , Marzullo P. , Landini L. 
Published: August 2020

:
The idea that performing a proper succession of imaging tests and techniques allows an accurate and
early diagnosis of cardiac amyloidosis, avoiding the need to perform the myocardial biopsy, is becoming increasingly
popular. Furthermore, being imaging techniques non-invasive, it is possible to perform the follow-up of the
pathology through repeated image acquisitions.

:
In the present review, the various innovative imaging methodologies are presented, and it is discussed how they
have been applied for early diagnosis of cardiac amyloidosis (CA), also to distinguish the two most frequent
subtypes in CA: immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR); this allows
to perform the therapy in a targeted and rapid manner.
A Meta-analysis of Randomized Controlled Trials of the Effect of Probiotic Food or Supplement on Glycemic Response and Body Mass Index in Patients with Type 2 Diabetes, Updating the Evidence
Authors: Jafarabadi Mohammad Asghari , Dehghani Azadeh , Khalili Leila , Barzegar Ali , Mesrizad Mahdi , Hassanalilou Tohid 
Published: August 2020

Background:
To investigate the effects of probiotics on glucose metabolism and body mass
index (BMI), and compare the efficacy of probiotic food with the probiotic supplement in patients with
type 2 diabetes mellitus using a meta-analysis of randomized, controlled trials.

Methods:
Online databases Embase, Web of Science, and PubMed were searched until November 2019
to identify eligible articles. Fourteen trials were included.

Results:
Probiotic consumption reduced fasting plasma glucose (FPG) (SMD=-0.38, 95% CI: -0.76 to
0.01), glycosylated hemoglobin (HbA1c) (SMD=-0.64, 95% CI: -0.91 to -0.38), fasting insulin concentration
(SMD=-0.48, 95% CI, -0.81 to -0.15), HOMA-IR (SMD=-1.01, 95% CI, -1.51 to -0.52), and
BMI (SMD=-0.02, 95%CI, -0.17 to 0.13) in intervention groups compared with control groups. Subgroup
analysis was conducted to trials with probiotic foods and probiotic supplements. Both of probiotic
foods (SMD: -0.65, 95% CI: -1.04 to -0.26; SMD: -1.17, 95% CI: -2.14 to -0.20, respectively) and
supplements (SMD: -0.64, 95% CI: -1.01 to -0.27; SMD: -0.98, 95% CI: -1.55 to -0.40, respectively)
made significant reduction in HbA1c and HOMA.IR. Meta-analysis of trials with probiotic foods found
non-significant changes in FBG and fasting insulin concentration (SMD: 0.11, 95% CI: -0.52 to 0.75;
SMD: -0.14, 95% CI: -0.48 to 0.20, respectively); however the changes in trials with probiotic supplements
were significant (SMD: -0.73, 95% CI: -1.22 to -0.23; SMD: -0.57, 95% CI: -0.97 to -0.17,
respectively). Probiotic foods cause a non-significant raise in BMI (SMD: 0.23, 95% CI: -0.03 to
0.49); however, meta-analysis of trials with probiotic supplements found a non-significant reduction in
BMI (SMD: -0.13, 95% CI: -0.31 to 0.04).

Conclusions:
The present meta-analysis suggests that consuming probiotics could improve glucose metabolism
and affect body weight, with a potentially greater effect when probiotics are used as supplements.
Theoretical Investigation on Structural and Magnetic Properties of Mn-doped and C co-doped Zn12Se12 Nanoclusters
Authors: Chen Liangyan , Fang Chao , Liu Weihua 
Published: August 2020

Background:
Mn doped ZnSe low dimensional materials are attractive for different biological
labels, gene silencing and dilute-magnetic device. ZnSe clusters are one of the basic building
blocks of quantum dots and even cluster-assembled nanodevices, stable structures of undoped ZnSe
clusters were established by previous pioneering work, and the Mn doped ZnSe clusters had been
investigated, but the stable clusters in the ferromagnetic state have not been found yet.

Objective:
Our work is mainly based on Mn doped clusters (Mn2Zn10Se12) and C codoped clusters
(Mn2Zn10Se11) structure, magnetic properties through theoretical calculations.

Methods:
First principle density functional theory calculation with Dmol3 is used to execute all calculations.

Results:
Mn atoms prefer to substitute the nearest neighbor Zn atom sites in the rhombi part, and C
atom prefers to occupy Se atom sites with shortest Mn-C bond length in Zn12Se12 nanocluster doping.
Mn doped clusters (Mn2Zn10Se12) are in antiferromagnetic states and the most stable C codoped clusters
(Mn2Zn10Se11) are in ferromagnetic states. Magnetic behavior localized at the 3d orbitals of
transitional metal Mn, 4p orbital of atom Se and 2p orbital of C atom. Mn2Zn10Se12 clusters are in
antiferromagnetic states as the p-d hybridization introduced Mn-Mn superexchange mechanism. For
the ferromagnetism of Mn2Zn10Se12 nanocluster, hole mediated double exchange mechanism introduced
by C atom p-d hole state hybridization has been suggested.

Conclusion:
The codoping of C atom can stabilize the ferromagnetism of clusters through hole mediated
double exchange mechanism, which may be meaningful for the exploring materials for cluster-
assembled spin-electronic devices.
Co-medications and Drug-Drug Interactions in People Living with HIV in Turkey in the Era of Integrase Inhibitors
Authors: Yeşilbağ Zuhal , Şengül Emine İlay , Şenoğlu Sevtap , Aydın Özlem Altuntaş , Karaosmanoğlu Hayat Kumbasar 
Published: August 2020

Background:
Long life expectancy in people living with human immunodeficiency virus (PLWH) caused an increase in comorbidities and co-medications. We aimed to analyse co-medications and drug-drug interactions (DDIs) in antiretroviral therapy (ART)-naive PLWH in the era of integrase inhibitors.

Methods:
A retrospective observational study was conducted between January 2016-August 2019. Patients’ characteristics
and chronic co-medications were recorded. The university of Liverpool HIV drug interaction database was used for DDIs.

Results:
Among 745 patients, the chronic co-medication rate was 30.9%. Older age (p<0.001, OR:6.66, 95% CI: 3.86-
11.49) and female gender (p=002, OR:2.25, 95%:1.14-4.44) were independently associated with co-medication. Cardiovascular system (CVS) and central nervous system (CNS) drugs were most common co-medications. Older age (p<0.001,
OR:12.04, 95% CI:4.63-36.71), having heterosexual (HS) contact (p=0.003, OR:3.8, 95% CI:1.57-9.22) were independently
associated with CVS drugs use, while being men who have sex with men (MSM) (p=0.03, OR:2.59, 95% CI:1.11-6.03) was
associated with CNS drugs use. DDIs were seen in 37.4% of patients with co-medications. Antidiabetics (23.3%), CNS
(22.1%) and CVS drugs (19.8%) most commonly had DDIs. Contraindication was most commonly seen between inhaled
corticosteroids and elvitegravir/cobicistat. A number of non-ART drugs, elvitegravir/cobicistat, antidiabetics, vitamins were
independently associated with the presence of DDIs.

Conclusion:
Results suggested the need for attention about co-medication in PLWH regardless of whether they are young or
older. CNS drugs should be questioned more detailed in MSM, as well as CVS drugs in older HS patients.
Elvitegravir/cobicistat is significantly associated with DDIs and switching to an unboosted INSTI should be considered in
patients with multiple comorbidities.
Vital Tooth Whitening Techniques. A Literature Review
Authors: Kirk Pia Chatterjee 
Published: August 2020

Background:
Vital tooth whitening has become an integral part of esthetic dentistry and
remains one of the safest and most economical options today to improve dental esthetics without removing
tooth structure. The tooth whitening materials have evolved into three categories: dentist-
prescribed/dispensed in office, the dentist prescribed patient home use, and over-the-counter
purchased and applied by patients.

Objective:
This review outlines the latest advances in dentist prescribed vital teeth whitening techniques,
effects on tooth structure, soft tissues, and dental restoratives. Areas requiring additional research
are also discussed.

Methods:
Electronic and manual literature search was conducted for key words such as tooth bleaching, and dental
bleaching techniques using PubMed/MEDLINE, followed by manual selection of the studies that included whitening procedures in vital teeth.

Results:
The two main whitening agents are carbamide peroxide (CP) and hydrogen peroxide (HP
or H2O2) whose concentration, duration of contact and total treatment time can alter results. In addition,
factors including the type of stain and the age of the patient can affect results. Although
whitening agents can affect tooth structure, restorative materials, and gingival tissues, the changes
are temporary or can be treated using minimally invasive techniques.

Conclusion:
Areas requiring further research include the actual mechanism of whitening, its effect
on tooth structure and restorative materials, and the development of an easy method to quantitate
the degree of whitening in the dental office.
Concentraciones séricas de Beta-hidroxibutirato y su asociación con enfermedades posparto en bovinos de leche
Authors: Huertas-Molina Oscar Felipe , Guzman-Carazo Victor Manuel , Palacio-Baena Luis Guillermo , Zambrano-Varón Jorge Luis , Olivera-Angel Martha 
Published: August 2020

Objetivo. Determinar la prevalencia de cetosis bovina según las concentraciones séricas (mMol/Lt) de beta-hidroxibutirato (βHB) y estimar su asociación con enfermedades del posparto temprano en vacas lecheras. Materiales y métodos. Se realizó un estudio de corte transversal con información individual de los niveles sanguíneos de βHB y presentación clínica de enfermedades puerperales de n=1149 animales; además se evaluó la eficiencia de la prueba como predictora de enfermedad posparto. Posteriormente, se realizó X2 y un modelo de regresión logística final para explorar los factores asociados a la prevalencia de cetosis. La relación entre βHB sanguíneo, la presentación de cetosis y la ocurrencia de enfermedades puerperales se calculó analizando Característica Operativa del Receptor (Receiver Operating Characteristic -ROC). Resultados. Según los niveles de βHB, la prevalencia de cetosis fue de 7,9%, cetosis clínica 0.6% y cetosis subclínica 7.3 %. La prueba fue predictora de enfermedad puerperal (LR+ del 13.6). La condición corporal ³ 3.5, número de partos igual a 2 y ≥3, la presentación de retención de placenta, fiebre de leche y la enfermedad posparto, son factores de riesgo de cetosis. El análisis de la curva ROC mostró que la medición de βHB (≥ 1.2 mMol/Lt) en sangre sirve para diagnosticar cetosis (p<0.0001). Conclusiones. La medición de niveles sanguíneos de βHB permitió determinar que la presentación de cetosis es baja, es una alerta no solamente para esta enfermedad sino para las enfermedades del posparto temprano. Los resultados de este estudio confirman lo reportado en estudios previos sobre los factores de riesgo de cetosis.
Comparing Computed Tomography–Derived Augmented Reality Holograms to a Standard Picture Archiving and Communication Systems Viewer for Presurgical Planning: Feasibility Study
Authors: Dallas-Orr David , Penev Yordan , Schultz Robert , Courtier Jesse 
Published: August 2020

BackgroundPicture archiving and communication systems (PACS) are ubiquitously used to store, share, and view radiological information for preoperative planning across surgical specialties. Although traditional PACS software has proven reliable in terms of display accuracy and ease of use, it remains limited by its inherent representation of medical imaging in 2 dimensions. Augmented reality (AR) systems present an exciting opportunity to complement traditional PACS capabilities.ObjectiveThis study aims to evaluate the technical feasibility of using a novel AR platform, with holograms derived from computed tomography (CT) imaging, as a supplement to traditional PACS for presurgical planning in complex surgical procedures.MethodsIndependent readers measured objects of predetermined, anthropomorphically correlated sizes using the circumference and angle tools of standard-of-care PACS software and a newly developed augmented reality presurgical planning system (ARPPS).ResultsMeasurements taken with the standard PACS and the ARPPS showed no statistically significant differences. Bland-Altman analysis showed a mean difference of 0.08% (95% CI –4.20% to 4.36%) for measurements taken with PACS versus ARPPS’ circumference tools and –1.84% (95% CI –6.17% to 2.14%) for measurements with the systems’ angle tools. Lin’s concordance correlation coefficients were 1.00 and 0.98 for the circumference and angle measurements, respectively, indicating almost perfect strength of agreement between ARPPS and PACS. Intraclass correlation showed no statistically significant difference between the readers for either measurement tool on each system.ConclusionsARPPS can be an effective, accurate, and precise means of 3D visualization and measurement of CT-derived holograms in the presurgical care timeline.
The Relationship Between Smartphone-Recorded Environmental Audio and Symptomatology of Anxiety and Depression: Exploratory Study
Authors: Di Matteo Daniel , Fotinos Kathryn , Lokuge Sachinthya , Yu Julia , Sternat Tia , Katzman Martin A , Rose Jonathan 
Published: August 2020

Background
Objective and continuous severity measures of anxiety and depression are highly valuable and would have many applications in psychiatry and psychology. A collective source of data for objective measures are the sensors in a person’s smartphone, and a particularly rich source is the microphone that can be used to sample the audio environment. This may give broad insight into activity, sleep, and social interaction, which may be associated with quality of life and severity of anxiety and depression.

Objective
This study aimed to explore the properties of passively recorded environmental audio from a subject’s smartphone to find potential correlates of symptom severity of social anxiety disorder, generalized anxiety disorder, depression, and general impairment.

Methods
An Android app was designed, together with a centralized server system, to collect periodic measurements of the volume of sounds in the environment and to detect the presence or absence of English-speaking voices. Subjects were recruited into a 2-week observational study during which the app was run on their personal smartphone to collect audio data. Subjects also completed self-report severity measures of social anxiety disorder, generalized anxiety disorder, depression, and functional impairment. Participants were 112 Canadian adults from a nonclinical population. High-level features were extracted from the environmental audio of 84 participants with sufficient data, and correlations were measured between the 4 audio features and the 4 self-report measures.

Results
The regularity in daily patterns of activity and inactivity inferred from the environmental audio volume was correlated with the severity of depression (r=−0.37; P<.001). A measure of sleep disturbance inferred from the environmental audio volume was also correlated with the severity of depression (r=0.23; P=.03). A proxy measure of social interaction based on the detection of speaking voices in the environmental audio was correlated with depression (r=−0.37; P<.001) and functional impairment (r=−0.29; P=.01). None of the 4 environmental audio-based features tested showed significant correlations with the measures of generalized anxiety or social anxiety.

Conclusions
In this study group, the environmental audio was shown to contain signals that were associated with the severity of depression and functional impairment. Associations with the severity of social anxiety disorder and generalized anxiety disorder were much weaker in comparison and not statistically significant at the 5% significance level. This work also confirmed previous work showing that the presence of voices is associated with depression. Furthermore, this study suggests that sparsely sampled audio volume could provide potentially relevant insight into subjects’ mental health.
URGENSI LITERASI MEDIA SOSIAL DALAM MENANGKAL ANCAMAN BERITA HOAX DI KALANGAN REMAJA KELURAHAN BALEARJOSARI KECAMATAN BLIMBING KOTA MALANG
Authors: Asokti Priambodo Galih 
Published: August 2020

Media sosial saat ini sudah semakin berkembang dan memiliki berbagai jenisnya masing-masing. Namun semakin majunya teknologi, banyak orang yang menyalahgunakan media sosial untuk menyebarkan berita hoax. Penelitian ini bertujuan untuk : (1) Mengetahui pemahaman literasi media sosial dikalangan remaja Kelurahan Balearjosari Kecamatan Blimbing Kota Malang, (2) Mengetahui pemahaman Remaja Kelurahan Balearjosari Kecamatan Blimbing Kota Malang mengenai berita hoax, (3) Untuk mengetahui kepercayaan remaja Kelurahan Balearjosari Kecamatan Blimbing Kota Malang pada berita hoax. Penelitian ini menggunakan teknik penelitian deskriftif kualitatif. Pengumpulan data diperoleh melalui observasi secara langsung dan mendokumentasi hal-hal yang berkaitan dengan penelitian serta wawancara mendalam kepada enam informan. Berdasarkan penelitian diperoleh hasil sebagai berikut: (1) Kemampuan literasi media remaja Kelurahan Balearjosari berada pada tahapan awal, (2) Kemampuan remaja Kelurahan Balearjosari menelaah berita hoax termasuk dalam kategori awal, (3) Penyebaran berita hoax mempengaruhi kepercayaan informan terhadap berita yang ada di media sosial sehingga informan memiliki pandangan sendiri mengenai berita yang ada di media sosial.