bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds
Authors: Criado-Mesas Lourdes , Ballester Maria , Crespo-Piazuelo Daniel , Castelló Anna , Fernández Ana I. , Folch Josep M. 
Published: June 2020

AbstractIntramuscular fat content and its fatty acid composition affect porcine meat quality and its nutritional value. The present work aimed to identify genomic variants regulating the expression in the porcine muscle(Longissimus dorsi)of 45 candidate genes for lipid metabolism and fatty acid composition in three experimental backcrosses based on the Iberian breed. Expression genome-wide association studies (eGWAS) were performed between the muscle gene expression values, measured by real-time quantitative PCR, and the genotypes of 38,426 SNPs distributed along all chromosomes. The eGWAS identified 186 eSNPs located in tenSus scrofaregions and associated with the expression ofACSM5,ACSS2,ATF3,DGAT2,FOSandIGF2(FDR < 0.05) genes. Two expression quantitative trait loci (eQTLs) forIGF2andACSM5were classified ascis-acting eQTLs, suggesting a mutation in the same gene affecting its expression. Conversely, ten eQTLs showedtrans-regulatory effects on gene expression. When the eGWAS was performed for each backcross independently, only three commontrans-eQTL regions were observed, indicating different regulatory mechanisms or allelic frequencies among the breeds. In addition, hotspot regions regulating the expression of several genes were detected. Our results provide new data to better understand the functional regulatory mechanisms of lipid metabolism genes in muscle.
Nutritional value, antioxidant and antidiabetic properties of nettles (Laportea alatipes and Obetia tenax)
Authors: Mahlangeni Nomfundo Thobeka , Moodley Roshila , Jonnalagadda Sreekantha Babu 
Published: June 2020

AbstractNettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in the concentrations of crude protein, vitamin A, vitamin E and metals after cooking of nettles. Although cooking reduced the concentrations of essential elements in nettles, their contribution to the diet remained adequate. L. alatipes presented with reduced levels of Cd (from 1.86 to 0.810 mg kg−1) and Pb (from 2.87 to 1.88 mg kg−1) after cooking. Similarly, Cd (from 2.97 to 0.780 mg kg−1) and Pb (from 2.21 to 0.795 mg kg−1) levels in O. tenax decreased after cooking, demonstrating the significance of cooking. The antioxidant activity of the nettles was determined using the 2,2-diphenyl-l-picrylhydrazyl (DPPH) free radical and ferric reducing antioxidant power (FRAP) assays. The methanol extract of Obetia tenax showed high ferric reducing power whilst the radical scavenging activity was due to the presence of the bioactive molecule, β-carotene, in the plants which exhibited higher DPPH radical scavenging ability relative to test samples and standards. The in vitro antidiabetic activity of the extracts and compounds from the nettles was better than or comparable to that of the known standard, acarbose, which underscores the prospective antidiabetic properties of nettles. Overall, our study provides scientific validation for the ethno-medicinal use of nettles and supports their consumption, which highlights their potential as nutraceuticals.
Key Word Signing Has Higher Iconicity Than Sign Language
Authors: Rombouts Ellen , Maessen Babette , Maes Bea , Zink Inge 
Published: June 2020

Purpose
Key word signing (KWS) entails using manual signs to support the natural speech of individuals with normal hearing and who have communication difficulties. While manual signs from the local sign language may be used for this purpose, some KWS systems have opted for a distinct KWS lexicon. Distinct KWS lexicon typically aims for higher sign iconicity or recognizability to make the lexicon more accessible for individuals with intellectual disabilities. We sought to determine if, in the Belgian Dutch context, signs from such a distinct KWS lexicon (Spreken Met Ondersteuning van Gebaren [Speaking With Support of Signs; SMOG]) were indeed more iconic than their Flemish Sign Language (FSL) counterparts.

Method
Participants were 224 adults with typical development who had no signing experience. They rated the resemblance between a FSL sign and its meaning. Raw data on the iconicity of SMOG from a previous study were used. Translucency was statistically and qualitatively compared between the SMOG lexicon and their FSL counterparts.

Results
SMOG had an overall higher translucency than FSL and contained a higher number of iconic signs.

Conclusion
This finding may support the value of a separate sign lexicon over using sign language signs. Nevertheless, other aspects, such as wide availability and inclusion, need to be considered.
Diagnostik und Therapie der schweren akuten Pankreatitis in der Intensivmedizin
Authors: Wirtz Theresa H. , Puengel Tobias , Buendgens Lukas , Luedde Tom , Trautwein Christian , Koch Alexander 
Published: June 2020

AbstractAcute pancreatitis is a potentially life-threatening disease that requires intensive care, especially in severe cases. The present article is intended to illustrate the possibilities of a rational diagnosis of acute pancreatitis as well as to provide an overview of the stage-adapted therapy, which includes both conservative measures and interventional interdisciplinary treatment strategies.
Editorial
Authors: Proff Peter 
Published: June 2020

Liebe Kolleginnen und Kollegen,die Verfügbarkeit neuer Technologien sowie die Digitalisierung gewinnen
für die Kieferorthopädie des 21. Jahrhunderts zunehmend an Bedeutung
und erweitern das konventionelle Spektrum der diagnostisch-therapeutischen
Möglichkeiten, insbesondere auch im Rahmen der Therapie komplexer
Fälle und bei erwachsenen Patienten. Nach wie vor liegen die Kernkompetenzen
des Faches in der korrektiven Behandlung von Zahn- und Kieferfehlstellungen mit
Krankheitswert.
Kephalometrische Analyse der Gesichtsschädelentwicklung im
bayerischen Raum in den letzten 1500 Jahren
Authors: Rudzki Ingrid , Proske Martin , Sagner Thomas , Kirschneck Christian 
Published: June 2020

ZusammenfassungUntersuchungen, wie sich das Viszerokranium des Menschen
entwicklungsgeschichtlich verändert hat, sind bislang nur
unzureichend verfügbar. Das Ziel der vorliegenden Studie war es
daher, mittels radiologischer FRS-Bildgebung die Konfiguration des
Viszerokraniums frühmittelalterlicher Schädel
(500–800 n. Chr., N=66) aus der Staatssammlung für
Anthropologie und Paläoanatomie in München mit
Angle-Klasse-I-Okklusion mit jener der gegenwärtigen
Bevölkerung im gleichen Lebensraum (N=65, Angle-Klasse I) zu
vergleichen, um mögliche Veränderungen im Viszerokranium in
den vergangenen ca. 1500 Jahren zu erfassen. Es zeigte sich, dass der
orthognathe Gesichtstyp vor dem retrognathen und prognathen dominierte.
Zudem verkleinerte sich in den zwischen den beiden Gruppen liegenden 1500
Jahren der maxilläre Prognathiegrad signifikant, während der
mandibuläre Prognathiegrad zunahm mit Verkleinerung der sagittalen
interbasalen Relation. Die primär posteriore maxilläre
Neigung bei den mittelalterlichen Schädeln zeigte sich bei Rezenten
in Bezug zum maxillären Prognathiegrad anterior geneigt. Die
mandibuläre anteriore Inklination änderte sich nicht im
Charakter, war jedoch bei rezenten Individuen geringer ausgeprägt.
Die Prominenz des Pogonions nahm ab, während sich die
Größe des Kieferwinkels nahezu nicht veränderte. Die
Achsen der Inzisivi passten sich den skelettalen Veränderungen im
Sinne einer moderaten dentalen Kompensation an. Der Interinzisalwinkel blieb
dabei in seiner Größe konstant.
Akademisierung des Hebammenberufs (Teil 1): Chancen – und wie
sie in den Studiengängen bestmöglich genutzt werden
können
Authors: Bovermann Yvonne 
Published: June 2020

ZusammenfassungDie Reform des Hebammen-Berufsgesetzes war lange überfällig.
Die WHO fordert schon seid Jahren eine akademische
Primärqualifikation der Hebammen, die EU hat 2013 ihre entsprechende
Richtlinie geändert, sodass innerhalb der EU alle Länder die
Hebammenausbildung entsprechend ändern mussten, sofern sie das nicht
ohnehin schon getan hatten. Dennoch wurde die Reform in Deutschland
kontrovers diskutiert. Besonders seitens der ärztlichen Vertreter
und Vertreterinnen wurden zahlreiche Bedenken geäußert.
Dabei ist der Reformbedarf in der Hebammenausbildung Deutschlands enorm, die
letzte Änderung fand 1985 statt. Die WHO weist daraufhin, dass
über 50 Outcomes in der Geburtshilfe verbessert werden, wenn die
Qualität der Hebammenausbildung gesteigert wird. In der
Gesetzesreform liegt also ein enormes Potenzial. Besondere gesetzliche
Bestimmungen des neuen Hebammengesetzes sind zudem neuartig und
können vorbildhaft sein für andere Studiengänge der
Gesundheitsberufe, wie z. B. die Finanzierung der praktischen
Studienanteile und des Studierendengehaltes.
Zur Akademisierung des Hebammenberufs
Authors: Singer Dominique 
Published: June 2020

Liebe Leserinnen und Leserden Schwerpunkt dieser Ausgabe der Zeitschrift für Geburtshilfe und
Neonatologie (ZGN) bildet eine Diskussion um die Akademisierung des Hebammenberufs.
Den Anstoß dazu hat Prof. Franz Kainer mit einem Kommentar gegeben, in dem
er sich im vergangenen Jahr – in seiner Funktion als Präsident der
Deutschen Gesellschaft für Perinatale Medizin – zu dem Für
und Wider der Akademisierung geäußert hatte (Z Geburtsh Neonatol
2019; 223: 253–254). Nachdem diese zum damaligen Zeitpunkt bereits
„beschlossene Sache“ war, erschien es den Herausgebern der ZGN
sinnvoll, noch einen Schritt weiter zu gehen und zu fragen, wie die Chancen dieser
Entwicklung in den allerorten einzurichtenden Hebammenstudiengängen genutzt
und wie ihre Risiken vermieden werden könnten. Hierzu wurden 2
Beiträge – gewissermaßen „pro und contra“
– von berufener Seite erbeten, die nunmehr fertiggestellt wurden (Dank an
die AutorInnen!) und hier abgedruckt sind. Die befürwortenden Argumente
werden von Yvonne Bovermann aus dem Präsidium des Deutschen Hebammenverbands
e.V. vorgetragen, die kritischen Punkte von Joachim Graf et al. aus dem Institut
für Gesundheitswissenschaften und Department für Frauengesundheit am
Universitätsklinikum Tübingen erörtert, wobei divergierende
Einschätzungen zutage treten, aber auch eine grundsätzliche
Einigkeit in dem Bemühen um nachhaltigen Fortschritt erkennbar wird.
Therapieerfolg von Protonenpumpeninhibitoren bei der Therapie von Kontaktgranulomen
Authors: Heyduck Adrienne , Pickhard Anja , Olthoff Arno , Hoffmann Thomas , Reiter Rudolf 
Published: June 2020

ZusammenfassungGemäß der S2k-Leitlinie „Gastroösophageale Refluxkrankheit (engl. GERD)“ von 05/2014 wird bei der extraösophagealen GERD-Manifestation (z. B. mit Ausbildung eines Kontaktgranuloms, KG) eine empirische Protonenpumpeninhibitor (PPI)-Therapie in doppelter Standarddosis (z. B. Pantoprazol 40 mg 2-mal/Tag) über 8 Wochen angeraten. Valide Studiendaten existieren hierzu jedoch nicht.Im Rahmen einer prospektiven Studie von 05/2015–12/2019 erhielten 39 Patienten mit endoskopisch nachgewiesenem KG konsekutiv randomisiert PPI in einfacher (1-mal PPI, n = 22) bzw. doppelter Standarddosis (2-mal PPI, n = 17) für 8 Wochen. Es wurden bei Erstvorstellung und bei Kontrolle nach 4 Monaten ein möglicher gastrolaryngealer Reflux sowie Halssensationen, Räusperneigung oder Heiserkeit erfasst und eine Videolaryngostroboskopie durchgeführt, um die Befundentwicklung des Granuloms zu beurteilen (Progredienz, gleichbleibend, Remission < 50 %, > 50 % oder komplett). Die beiden Gruppen wurden miteinander verglichen.Das Granulom war in 40 % der Fälle nach Therapie mit 1-mal PPI und in 77 % der Fälle mit 2-mal PPI verschwunden bzw. regredient (p < 0,05). Bei Kontrolle waren 23 % der Patienten mit 1-mal PPI völlig symptomlos und 77 % der Patienten mit 2-mal PPI. Halssensationen wurden bei Erstvorstellung mit 64 % als häufigstes Symptom angegeben. Bei der Kontrolle nach PPI-Therapie in einfacher bzw. doppelter Standarddosis waren Halssensationen nur noch in 33 % bzw. 15 % der Fälle bei Granulomremission nachweisbar. Bei Persistenz des Granuloms waren sie jedoch kaum beeinflussbar.Die Therapie eines KG mit PPI in doppelter Standarddosis ist effektiver als in einfacher Standarddosis. Diese Ergebnisse müssen an einem größeren Kollektiv bestätigt werden.
Periorbital Surgical Anatomy
Authors: Neves José Carlos , Arancibia-Tagle Diego , Medel-Jiménez Ramón , Vásquez Luz María 
Published: June 2020

AbstractThis article discusses the periocular anatomy region thoroughly because its knowledge in detail is of paramount importance for any surgeon dedicated to periocular surgery or any practitioner who dedicate their practice to aesthetic medicine. Mastering the anatomical details permits obtaining consistently good results with the minimal amount of complications possible.
Availability of risky geoengineering can make an ambitious climate mitigation agreement more likely
Authors: Fabre Adrien , Wagner Gernot 
Published: June 2020

AbstractSome countries prefer high to low mitigation (H ≻ L). Some prefer low to high (L ≻ H). That fundamental disagreement is at the heart of the seeming intractability of negotiating a climate mitigation agreement. Modelling global climate negotiations as a weakest-link game brings this to the fore: Unless everyone prefers H to L, L wins. Enter geoengineering (G). Its risky and imperfect nature makes it arguably inferior to any country’s preferred mitigation outcome. However, absent a global high-mitigation agreement, countries facing disastrous climate damages might indeed wish to undertake it, effectively ranking H ≻ G ≻ L. Meanwhile, those least affected by climate damages and, thus, least inclined to agree to an ambitious mitigation agreement, might be unwilling to engage in risky geoengineering, resulting in L ≻ H ≻ G. With these rankings, all players prefer H to G, and the mere availability of a credible geoengineering threat might help induce an ambitious climate mitigation agreement (H). The analysis here introduces the simplest possible model of global climate negotiations and derives the conditions for this outcome. These conditions may indeed be likely, as long as geoengineering is viewed as a credible albeit risky emergency response given the danger of low mitigation levels.
Emotion recognition and confidence ratings predicted by vocal stimulus type and prosodic parameters
Authors: Lausen Adi , Hammerschmidt Kurt 
Published: June 2020

AbstractHuman speech expresses emotional meaning not only through semantics, but also through certain attributes of the voice, such as pitch or loudness. In investigations of vocal emotion recognition, there is considerable variability in the types of stimuli and procedures used to examine their influence on emotion recognition. In addition, accurate metacognition was argued to promote correct and confident interpretations in emotion recognition tasks. Nevertheless, such associations have rarely been studied previously. We addressed this gap by examining the impact of vocal stimulus type and prosodic speech attributes on emotion recognition and a person’s confidence in a given response. We analysed a total of 1038 emotional expressions according to a baseline set of 13 prosodic acoustic parameters. Results showed that these parameters provided sufficient discrimination between expressions of emotional categories to permit accurate statistical classification. Emotion recognition and confidence judgments were found to depend on stimulus material as they could be reliably predicted by different constellations of acoustic features. Finally, results indicated that listeners’ accuracy and confidence judgements were significantly higher for affect bursts than speech-embedded stimuli and that the correct classification of emotional expressions elicited increased confidence judgements. Together, these findings show that vocal stimulus type and prosodic attributes of speech strongly influence emotion recognition and listeners’ confidence in these given responses.
Mechanical adaptation of monocytes in model lung capillary networks
Authors: Dupire Jules , Puech Pierre-Henri , Helfer Emmanuèle , Viallat Annie 
Published: June 2020

Significance
Proper circulation of white blood cells (WBCs) in the pulmonary blood capillary network is crucial for a healthy immune watch. The remarkable mechanical properties of monocytes, a class of WBCs, allow them to gradually adapt their shape as they pass through the narrowest capillaries, ensuring a transition from a slow motion by hops at the entrance of the capillary network to a smooth and rapid circulation. The key parameters are a low cell cortical tension allowing adaptation of the cell shape, but high enough to prevent cell breakage when passing through the network bifurcations, and a high cell internal viscosity to maintain an elongated shape throughout the network.
Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish
Authors: Lex Kirsten , Maia Gil Mariana , Lopes-Bastos Bruno , Figueira Margarida , Marzullo Marta , Giannetti Kety , Carvalho Tânia , Ferreira Miguel Godinho 
Published: June 2020

Significance
Cancer incidence increases exponentially in human midlife. Even though mutation accumulation in somatic tissues results in increased tumorigenesis, it is currently not understood how aging contributes to cancer. Telomeres, the ends of eukaryotic linear chromosomes, shorten with each cell division. Here, we show that telomere shortening contributes to cancer in a noncell autonomous manner. Using embryo chimeras of telomerase-deficient zebrafish generated from melanoma-prone fish, we show that tumors arise more frequently, multiply faster, and become more invasive in animals with shorter telomeres. Telomere shortening gives rise to increased senescence and systemic inflammation. We observed increased melanoma dissemination in zebrafish larvae with very short telomeres. Thus, telomere shortening similar to human aging, generates a chronic inflammatory environment that increases cancer incidence.
A chemically stabilized sulfur cathode for lean electrolyte lithium sulfur batteries
Authors: Luo Chao , Hu Enyuan , Gaskell Karen J. , Fan Xiulin , Gao Tao , Cui Chunyu , Ghose Sanjit , Yang Xiao-Qing , Wang Chunsheng 
Published: June 2020

Significance
Sulfur is a promising cathode material for rechargeable lithium batteries due to its high capacity, low cost, abundance, and high sustainability. However, lithium sulfur batteries suffer from poor cycle life and low energy density under lean electrolyte conditions because of the dissolution of lithium polysulfide intermediates. Here, we report that the chemical bonding between sulfur and carbon/oxygen in an oxygen-rich dense carbon host can stabilize sulfur and improve the stability of lean electrolyte lithium sulfur batteries. This work opens up a way to develop chemical bonding-stabilized sulfur materials for stable and high-energy lithium sulfur batteries.
Irony, humor or both?
Authors: Hirsch Galia 
Published: June 2020

This contribution revisits the difference between irony and humor taking into
account new approaches shedding light on the complicated relationship between irony
and humor (Dynel 2013; Gibbs, Bryant & Colston 2014; Garmendia 2014; Kapogianni 2011; Piskorska 2014; Yus 2016). In
previous research (Hirsch 2011a, 2011b), the differentiation between irony
and humor was established based on a comparative model, which distinguished between
cues for irony and cues for humor through pragmatic analysis of source texts and
their translations.
In view of some of the new accounts (Dynel
2013; Kapogianni 2011; Piskorska 2014), the study purports to adapt
the model, incorporating the concept of surrealistic irony and concluding that
differences in the use of explicitation strategies in translation are still a
decisive tool in setting the boundaries between irony and humor.
Ultra-flexible, stretchable, highly conductive and multi-functional textiles enabled by brush-painted PEDOT:PSS
Authors: Jin In Su , Lee Woosung , Lim Seung Ju , Ko Jae Hoon , Jung Jae Woong 
Published: June 2020

Abstract
Electronic textile (E-textile) with excellent electrical/mechanical properties in large area is an essential component for wearable electronics. We herein demonstrated that brush-painting is a promising printing technique of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) on fabric substrates to prepare ultra-flexible, stretchable, and highly conductive E-textiles. The brush-painting allows uniform film surface with much lower sheet resistance which is opposite to agglomerated particulates of the film from the drop-casting. As a result, the PEDOT:PSS-based E-textiles achieve high conductivity of 6.4 S cm−1 after successive bush-painting up to 50 times with excellent mechanical properties including bending, stretching, and washing stability. The brush-painted E-textiles exhibit excellent Joule heating properties with low operative voltage and quick response time. In addition, the large-area piezoresistive sensors have been realized by the brush-painted E-textiles, suggesting its great potential of the brush-painting PEDOT:PSS toward multi-functional smart textiles or wearable electronics.
Mathematical Analysis of Wind Turbine Blade at various Angle of attack and Reynold Number
Authors: Zunaid M. , Mustafa Md. Gulam 
Published: June 2020

Abstract
This work utilizes only the closure system k-ω SST RANS to model wake growth and resolution for both a single fully resolved rotating turbine and two fully resolved rotating turbines in-line. These simulations have been effective in predicting wake growth and resolutions, as well as predicting downstream turbine speed deficits. The precise wake structure and helical tendencies also showed. The findings of vorticity also showed a precise structure of the wake and helical tendencies. Results clearly shows the variation of Cl and Cd with angle of attack. Thus, for a particular Reynold number the optimum angle of attack came between 350 and 400. With the increase in the Reynold number Cl also increases, and wind turbine efficiency increases by 20%.
Experimental investigations for erosive wear of Mild Steel Pipe bends at different positions in Pneumatic Conveying System (PCS)
Authors: Yadav Bharat Singh , Singh R C , Chaudhary Rajiv 
Published: June 2020

Abstract
Pharmaceutical and chemical industries have been using transportation of various material/powder through pipes. The bend was punctured in the conveying system during the flow of material and finally stops the production. The scientists and researchers are working on material and mechanism to reduce the material loss of the bends. An experimental investigation have been carried out for erosive wear in pipe bends of a pneumatic conveying pipe line. Six bends has been considered for the investigation of wear at 90° from rotary feeder to air filter. The Comparison of erosive wear was investigated for all six pipe bends. The bend 2 was the most critical place in the pipeline. Other five bends had less erosion than the bend 2 due to maximum velocity of the flow.
Effect of argon flow rate on the weld bead characteristics of TIG coating
Authors: Angra Surjit , Thakur Lalit , Singh Jasbir 
Published: June 2020

Abstract
The research workinvestigatethe weld bead characteristics of WC-CoCr coatingfabricated by using tungsten inert gas welding process. Owing to the heat generated during the TIG coating, the extent of the temperature rise is adequate to cause the significant changes inthe melt dimensions of the coating. Toolmakers microscope has been used to capture the coating cross-section obtained at different values of argon flow rate. ImageJ software has been used to measure the porosity level in the coatings. The results shows that higher flow rate of argon gas increases the porosity and weld contamination in thecoating, because of the turbulencetakes place at higher flow rate.