bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chitosan-miRNA Functionalized Microporous Titanium Oxide Surface via A Layer-by-layer Approach with a Sustained Release Profile for Enhanced Osteogenic Activity
Authors: Wu Kaimin , Liu Mengyuan , Li Nan , Zhang Li , Meng Fanhui , Zhao Lingzhou , Liu Min , Zhang Yumei 
Published: May 2020

Abstract
Background: Biofunctionalization of titanium implants for high osteogenic ability holds the hope for advanced implant of promoted osseointegration, especially in the compromised bone condition. In this study, using chitosan-miRNA (CS-miRNA) complex and sodium hyaluronate (HA) as the positively and negatively charged polyelectrolyte, the polyelectrolyte multilayers (PEMs) were fabricated using the layer-by-layer approach on the microarc oxidized (MAO) Ti surface via silane glutaraldehyde coupling. Methods: Dynamic contact angle and scanning electron microscopy were firstly analyzed to monitor the layer accumulation. RiboGreen was used to quantify the miRNA loading and release profile in phosphate-buffered saline. In vitro transfection efficiency and cytotoxicity were investigated after mesenchymal stem cells (MSCs) being seeded on the CS-antimiR-138/HA PEM functionalized microporous Ti surface. The in vitro osteogenic differentiation of MSCs and in vivo osseointegration were also inspected. Results: The surface wettability alternately changed during the formation of PEMs. The CS-miRNA nanoparticles distributed evenly along the MAO surface. The miRNA loading amount increased with the bilayer number increasing. More importantly, a sustained miRNA release of over approximately 2 week was obtained. In vitro transfection revealed that the CS-antimiR-138 nanoparticles were taken up efficiently by the cells and caused significant knockdown of miR-138 without showing significant cytotoxicity. The CS-antimiR-138/HA PEM surface enhanced osteogenic differentiation of MSCs on it in terms of enhanced alkaline phosphatase, collagen product and extracellular matrix mineralization. In the rat model, it led to dramatically enhanced in vivo osseointegration. Conclusions: All these findings demonstrate that novel CS-antimiR-138/HA PEM functionalized microporous Ti implant exhibits sustained release of CS-antimiR-138, and obviously enhances the in vitro osteogenic differentiation of MSCs and dramatically enhanced in vivo osseointegration. This novel miRNA functionalized Ti implant may be used in clinic to allow more effective and robust osseointegration.
Clinical Observation of the Number of Lymphocytes and T Cell Subsets in Patients with COVID-19 at Different Stages
Authors: Bai Jing , Zhou Hui , Dai Bao-sheng 
Published: May 2020

Abstract
To explore the changes of lymphocytes and T cell subsets at different stages in patients with COVID-19. 86 patients with COVID-19 were enrolled, and the dynamic changes of peripheral blood lymphocytes and T cell subsets of CD3+, CD4+, and CD8+ were measured on admission, after treatment for1 week, 2 weeks, and before discharge. There were no significant differences in the number of white blood cells and lymphocytes between admission and 2 weeks after treatment or before discharge in severe patients. The counts of CD3+, CD4+, and CD8+ T cells decreased significantly on admission. After 2 weeks of treatment, the CD3+ counts were significantly higher than that on admission. The CD4+ and CD8+ counts increased significantly after 1 week of treatment, and went up remarkably before discharge compared with that on admission. There was no significant difference in the number of CD3+ cells between the mild group and the control group on admission, but it was significantly lower in the severe group than that in the control group and the mild group. The CD4+ and CD8+ counts decreased significantly in both mild and severe patients on admission, and increased significantly before discharge. At the time of discharge, the CD4+ counts in the severe and mild groups were still significantly lower than in the control group, but there was no significant difference in CD8+ counts among the three groups. The counts of CD3+,CD4+,and CD8+ T cells in the patients with COVID-19 is significantly correlated with the short-term prognosis, and is more sensitive than lymphocytes. In the earliest stage, the numbers of CD4+ and CD8+ cells are more sensitive to early reduction and faster to late recovery.
Optimizando las Posibilidades de las TICs en Educación
Authors: Fainholc Beatriz 
Published: May 2020

Se presenta la experiencia de la investigación-acción en realización por la Cátedra de Tecnología Educativa de la Universidad Nacional de La Plata, Argentina, por quien suscribe, con el apoyo tecnológico del CTER- Centro de Tecnología y reforma Curricular de la Universidad de Illinois-, USA, como una muestra de las posibilidades de explotar y combinar riqueza que brindan los recursos tecnológicos de la “cibercultura” con las TICs al reamplificar en cantidad y calidad, la educación universitaria presencial convencional, en la modalidad del blended learning.AbstractThis action-research Project is in progress by the Educational Technology Course in Education Sciences Faculty at the National University of La Plata, Buenos Aires, Argentina by the mentioned author with the technologic support of CTER- Center of Technology and Curricular Reform of Illinois University at Urban Champeign, USA, as a sample of the explotation and combination posibilities of ICT resources and its cyberculture in order to amplify, in quantity and quality, the university conventional face to face education, introducing the blended learning.
A utilização do software GBOL no ensino de tópicos específicos de Genética
Authors: Almeida Silva Andréia , Castilho Razera Júlio César 
Published: May 2020

Nas últimas décadas foram apontadas algumas deficiências no ensino das disciplinas científicas. Críticas foram feitas sobre aulas de conteúdos muito abstratos que não estimulam a participação, ointeresse e, conseqüentemente, a aprendizagem significativa dos alunos, mesmo com extraordinários recursos que a tecnologia disponibiliza ao processo educacional. Há, portanto, necessidade de melhorconhecer e discutir a utilização das diferentes ferramentas tecnológicas, a fim de favorecer a qualidade do ensino. Nesta pesquisa, verificou-se o impacto da utilização do software GBOL no processo de ensino de tópicos específicos de Genética em alunos do Ensino Médio, com foco na melhoria de nível de aprendizagem, motivação e interesse dos alunos. Os dados foram coletados em pré e pós-testes durante a realização de mini-curso.AbstractSome deficiencies have been indicated in the teaching of scientific subjects in the last decades. Classes have been reviewed for not stimulating the students’ participation, interests, and consequently, significative learning despite extraordinary resources due to technologic availability in the education process. Thus, it is very important to have more information to discuss about the usage of different technologic tools in order to support the quality in the teaching. This research verified the GBOL software utilization impact in the teaching of specific topics in Genetics with high school students, in the perspective of improving the students’ learning level, motivation, and interest. The data were collected through pre and post exams during the presentation of a workshop.
El blog como recurso educativo
Authors: Bohórquez Rodríguez Emilio 
Published: May 2020

Internet nos ofrece todo un caudal de oportunidades para optimizar el proceso de enseñanza-aprendizaje. A pesar de estar asociado a su habitual carácter intimista y cotidiano, el blog es un recurso de amplias potencialidades a la hora de trabajar colaborativamente en el aula contenidos preferentemente transversales, así como competencias básicas. En definitiva, el weblog permite todo un abanico de experiencias compartidas que permiten al alumno la reflexión y el contraste de ideas propias y ajenas. AbstractInternet offers a whole variety of opportunities to optimize the teaching-learning process. Despite being associated to its common intimate and ordinary nature, the blog is a resource with great potencials when working mainly transversal contents, as well as basic competences, cooperatively in the clasrroom.Summarizing, the weblog allows a full range of shared experiences that let the student reflect and contrast the own and others ideas.
Innovar con blogs en la enseñanza universitaria presencial
Authors: Salinas María Isabel , Viticcioli Stella María 
Published: May 2020

Este artículo pretende describir el potencial de los blogs como herramientas para la innovación curricular en el contexto de la enseñanza universitaria presencial. Asimismo, relata una experiencia de implementación de este recurso en una asignatura y, a través del análisis de sus resultados, precisa las razones por las cuales dicha integración contribuyó a mejorar la calidad de los procesos de enseñanza-aprendizaje implicados. AbstractThis article tries to describe the potential of blogs as tools for curricular innovation in the context of face to face university education. Moreover, it relates an experience of implementation of this resource in a subject and, through the analysis of its results, it points out the reasons for which this integration contributed to improve the quality of the implied teaching and learning processes.
Construcción de un instrumento para la evaluación de las estrategias de enseñanza de cursos telemáticos de formación universitaria
Authors: Cabero Almenara Julio , López Meneses Eloy 
Published: May 2020

Con este estudio intentamos aproximarnos a los modelos de enseñanza que subyacen en los cursos virtuales de formación. La investigación se encuentra organizada en cuatro fases. Una primera fase de revisión de la literatura científica para valorar los materiales para la formación en red. Una segunda fase, centrada en la construcción, selección y precisión de los contenidos de dicho instrumento didáctico de evaluación. Para ello se realizará dos estudios Delphi. En la tercera fase, se ofrece el instrumento en su versión telemática alojada en el blog: http://adecur.blogspot.com/. La última fase consiste en la puesta en práctica del A.D.E.C.U.R. AbstractWith this study we try to approach to the teaching models that underlie in virtual formation courses. The research is organized in four phases. At first phase we did a revision of the most outstanding scientific literature to value the materials for net training. In the second phase, based in the construction, selection and precision of contents of this didactic instrument of evaluation will be carried out two Delphi studies. In the third phase, we offers the instrument in their telematic version put up in the blog: http://adecur.blogspot.com/. The last phase consists on put into practice the A.D.E.C.U.R.
Propuesta de indicadores para evaluar y promover el aprendizaje cooperativo en un debate virtual
Authors: Casanova Uribe Marly Odette , Alvarez Valdivia Ibis Marlene , Gómez Alemany Isabel 
Published: May 2020

A partir de una revisión teórica y de un trabajo de investigación empírica realizados previamente, se desarrollan orientaciones que pueden ser útiles para la aplicación del aprendizaje cooperativo en contextos virtuales de comunicación asincrónica. Se sintetiza una propuesta de indicadores para evaluar y promover el aprendizaje cooperativo en un debate virtual. Se desarrollan los aspectos centrales en los que se fundamenta, seguidamente se presenta la propuesta de indicadores en base a la observación del discurso y a la evolución de la construcción de significado. Finalmente se completa con orientaciones generales para su aplicación. Abstract Taking a theoretical revision and an empirical research carried out previously as a starting point, guidelines are developed that may prove useful for the application of cooperative learning in virtual contexts of asynchronous communication. A proposal of indicators is synthesized in order to evaluate and to promote cooperative learning in a virtual debate. First the central aspects on which it is based are developed; then a proposal of indicators is presented on the basis of the observation of discourse and of the evolution of the construction of meaning. Finally the proposal is completed with general guidelines for the application.
Una política acertada y la formación permanente del profesorado, claves en el impulso de los centros TIC de Andalucía (España)
Authors: Pérez Rodríguez Mª Amor , Aguaded Gómez José Ignacio , Fandos Igado Manuel 
Published: May 2020

En este trabajo se exponen algunos de los resultados de una investigación llevada a cabo en Andalucía (España) para evaluar el impacto de la política de innovación educativa desarrollada por el gobierno de la región, mediante la implantación masiva de las Tecnologías de la Información y Comunicación (TIC) en centros de ense­ñanza de Primaria y Secundaria (Centros TIC). En concreto, se analizan las implicaciones de la administración educativa y de los centros ante las medidas de impulso para la integración de las TIC, no sólo a nivel institucional en cuanto a organización de centros, sino también en lo que se refiere a acciones de formación permanente del profesorado y las implicaciones y repercusiones en los procesos de enseñanza aprendizaje. Abstract This paper displays some of the results from research carried out in Andalusia (Spain) to evaluate the impact of the educational innovation policy developed by the regional government through widely introducing Information and Communication Technologies (ICT) in primary and secondary schools (ICT Centres). Specifically, the effect of the measures used to integrate ICTs on the educational administration and education centres is analysed. This integration is analysed not only at an institutional level, concerning the organization of the centres, but also in that referring to the permanent teacher’s training actions and the implications and repercutions in the teaching-learning processes and the classroom and thus its repercussions in teaching-learning processes.
Ventajas del uso de las TICs en el proceso de enseñanza-aprendizaje desde la óptica de los docentes universitarios españoles
Authors: Ferro Soto Carlos , Martínez Senra Ana Isabel , Otero Neira Mª Carmen 
Published: May 2020

Las TICs juegan un papel decisivo en el proceso de enseñanza-aprendizaje de las universidades europeas a la hora de alcanzar los retos planteados en el proyecto de convergencia de los diferentes sistemas nacionales (Espacio Europeo de Educación Superior –EEES-) referidos a la innovación en las formas de generación y transmisión del conocimiento y a la apuesta por una formación continuada a lo largo de toda la vida. Así las cosas, este trabajo presenta un estudio sobre la valoración que los docentes de las universidades españolas hacen sobre las ventajas que el uso de las TICs reportan a dicho proceso. La información acopiada mediante encuesta personalizada por correo electrónico pone de manifiesto que las principales ventajas son la ruptura de las barreras espacio-temporales, la posibilidad que ofrecen de interacción con la información y lo útil que resultan como herramienta de apoyo al aprendizaje. Por el contrario, la ventaja menos valorada ha sido el ahorro de tiempo que el profesor podría dedicar a otras tareas. AbstractICT are an important tool of the process of teaching-learning proposed by European Space of Higher Education (ESHE) in order to reach the challenges related to innovation on forms of generation and transmission of knowledge, and continued training along whole life. So, in this paper we analyze the advantages of ICT at the university education by spanish professors. The information gathered by means of personalized survey by e-mail reveals that the main advantages are breaking up barrier of spread and time, interaction with the information and proving tool of support to the learning. On contrary, saving time to other tasks is the minor considered aspect.
Uso de fuentes documentales –impresas y digitales- con fines académicos entre el alumnado universitario
Authors: Comas Forgas Rubén , Sureda Negre Jaume , Mut-Amengual Tomeu 
Published: May 2020

En este trabajo se presentan los resultados obtenidos en una investigación acerca de la frecuencia de uso de las bibliotecas –universitarias y no universitarias- e Internet entre el alumnado universitario para documentarse. También se describen las principales actividades académicas para las que los universitarios hacen uso de Internet como fuente de información. De los resultados se desprende que Internet monopoliza las búsquedas del alumnado y que la principal actividad para la que hacen uso de la Red es la elaboración de trabajos. AbstractIn this paper we present the results of an investigation of the frequency of library and Internet use by university students to locate information with academic purposes. It also describes the major academic activities for which the university students make use of Internet as an information source. The results show a monopoly of the Internet as search resource and that the main activity for which uses the Net is the elaboration of essays.
Plan-do-check-act en una experiencia tic en el aula: desde la idea a la evaluación
Authors: Vázquez Pérez Antonio 
Published: May 2020

Para desarrollar correctamente actividades TIC, nos podemos servir de técnicas contrastadas de planificación, como el “ciclo de Deming” o ciclo PDCA: P (Plan): planificación de objetivos, contenidos digitales, ordenadores, agrupamientos, hojas de trabajo, etc; D (Do): actuar, llevar a cabo lo planificado en el aula; C (Check), evaluar lo planificado y lo realizado y A (Act), analizar los resultados obtenidos, contrastarlos con los objetivos e incorporar mejoras de nuevo al ciclo.Plan-do-check-act is an information and communication technology (tic) experience in the classroom: from its idea to its evaluationAbstractTo be able to develop TIC activities properly, we can use contrasted techniques such as PDCA cycle: P (Plan): planning objectives, digital contents, computers, working groups, working schemes, number of lessons, etc.; D (Do): to be able to perform the planned work in the classroom; C (Check): to evaluate the planned and performed work; A (Act): to analyse the results we get contrasting them with the objectives and including the improvements in the new cycle.
La calidad de los objetos de aprendizaje producidos en la universidad de las ciencias informáticas
Authors: Ruiz Ortiz Lidia , Trujillo Casañola Yaimí , Ril Gil Yohandri 
Published: May 2020

Con el auge en la creación de Objetos de Aprendizaje (OA) para apoyar el proceso de enseñanza-aprendizaje en las universidades cubanas, ha cambiado de manera significativa la forma en que los docentes diseñan y preparan sus cursos, permitiéndoles actualizar su contenido con el uso cotidiano de la tecnología. Como parte de este proceso, se comienzan a tener en cuenta la forma de evaluar eficientemente la calidad de los Objetos de Aprendizaje que se producen. Para ello se consideran diferentes criterios a la hora de evaluarlos. En esta investigación se resumen las características, definiciones y ventajas de los OA. Se exponen además diferentes modelos de evaluación y estándares de catalogación. El objetivo principal de este trabajo es lograr conformar la base necesaria para fundamentar una guía que permita evaluar la calidad de los Objetos de Aprendizaje una vez creados en la Universidad de las Ciencias Informáticas, y de esta manera garantizar una mayor utilización y una mejor aceptación de los mismos.The quality of the learning objects produced at the university of information sciencesAbstractWith the boom in the creation of Learning Objects to support the teaching-learning process in Cuban universities, has significantly changed the way in which teachers design and prepare their courses, allowing them to update the content daily use of technology. As part of this process, they begin to consider how to efficiently evaluate the quality of learning objects that are produced. This will consider various criteria when evaluating them. This research summarizes the characteristics, definitions and benefits of OA. Also discussed different models of evaluation and documentation standards. The main objective of this work is to form the basis for founding a guide for evaluating the quality of learning objects once created at the University of Information Sciences, and thereby ensure greater use and greater acceptance of them.
Los procesos de evaluación en asignaturas presenciales, semipresenciales y no presenciales de la universidad de Lleida. Opinión de profesorado y estudiantes.
Authors: Flores Alarcia Òscar , Del Arco Bravo Isabel 
Published: May 2020

El artículo está basado en un estudio realizado con el objetivo de observar el desarrollo de los procesos de evaluación en diferentes asignaturas presenciales, semipresenciales y no presenciales de la Universidad de Lleida. Se recogieron datos a través de análisis documental de planificaciones, un cuestionario a profesorado y estudiantado y entrevistas a profesorado. Los datos mostraron diferentes percepciones sobre las estrategias de evaluación entre docentes y discentes. También que a medida que aumenta la no presencialidad se desarrollan más estrategias de evaluación continuada.Assessment processes in face-to-face, blended-learning and e-learning subjects at the university of Lleida. Opinion of teachers and students.AbstractThe article is based on a study carried out to observe the development of the assessment processes in face-to-face, blended-learning and e-learning subjects at the University of Lleida. We took data from documental analyses of the schedules, questionnaires at teachers and students and interviews at teachers. The data showed different perceptions of assessment strategies between teachers and students, as well as that continued assessment is more used in e-learning subjects than face-to-face subjects.
Estudio y aplicación de objetos de aprendizaje a través del uso de recursos educativos abiertos
Authors: Nappa Nora Raquel , Pandiella Susana Beatriz 
Published: May 2020

Esta investigación da cuenta de la planificación y desarrollo de una estrategia de aprendizaje utilizando Recursos Educativos Abiertos (REA). La misma se llevó a cabo con alumnos de nivel universitario, de los Profesorados en Química y Profesorado en Física y se abordó el estudio del tema Objetos de aprendizaje (OA). Los resultados obtenidos en el aprendizaje logrado por los alumnos son promisorios e indicativos de la potencialidad de los recursos educativos abiertos.Study and implementation of learning objects through the use of open educational resourcesAbstractThis research gives account of the planning and development of a learning strategy using open educational resources (REA). It was carried out with students at the University level professorships in chemistry and physics teachers and taken up the study of the topic (OA) learning objects. The results obtained in the learning achieved by students are promising and indicative of the potential of open educational resources.