bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple holographic models of black hole evaporation
Authors: Akers Chris , Engelhardt Netta , Harlow Daniel 
Published: August 2020

Abstract
Several recent papers have shown a close relationship between entanglement wedge reconstruction and the unitarity of black hole evaporation in AdS/CFT. The analysis of these papers however has a rather puzzling feature: all calculations are done using bulk dynamics which are essentially those Hawking used to predict information loss, but applying ideas from entanglement wedge reconstruction seems to suggest a Page curve which is consistent with information conservation. Why should two different calculations in the same model give different answers for the Page curve? In this note we present a new pair of models which clarify this situation. Our first model gives a holographic illustration of unitary black hole evaporation, in which the analogue of the Hawking radiation purifies itself as expected, and this purification is reproduced by the entanglement wedge analysis. Moreover a smooth black hole interior persists until the last stages the evaporation process. Our second model gives an alternative holographic interpretation of the situation where the bulk evolution leads to information loss: unlike in the models proposed so far, this bulk information loss is correctly reproduced by the entanglement wedge analysis. This serves as an illustration that quantum extremal surfaces are in some sense kinematic: the time-dependence of the entropy they compute depends on the choice of bulk dynamics. In both models no bulk quantum corrections need to be considered: classical extremal surfaces are enough to do the job. We argue that our first model is the one which gives the right analogy for what actually happens to evaporating black holes, but we also emphasize that any complete resolution of the information problem will require an understanding of non-perturbative bulk dynamics.
Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials
Authors: Pazan Farhad , Petrovic Mirko , Cherubini Antonio , Onder Graziano , Cruz-Jentoft Alfonso J. , Denkinger Michael , van der Cammen Tischa J. M. , Stevenson Jennifer M. , Ibrahim Kinda , Rajkumar Chakravarthi , Bakken Marit Stordal , Baeyens Jean-Pierre , Crome Peter , Frühwald Thomas , Gallaghar Paul , Guðmundsson Adalsteinn , Knol Wilma , O’Mahony Denis , Pilotto Alberto , Rönnemaa Elina , Serra-Rexach José Antonio , Soulis George , van Marum Rob J. , Ziere Gijsbertus , Mair Alpana , Burkhardt Heinrich , Neumann-Podczaska Agnieszka , Wieczorowska-Tobis Katarzyna , Fernandes Marilia Andreia , Gruner Heidi , Dallmeier Dhayana , Beuscart Jean-Baptiste , van der Velde Nathalie , Wehling Martin 
Published: August 2020

Abstract
Background
Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty.

Methods
A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimization in older frail adults on comprehensive frailty scores or partial aspects of frailty that were published from January 1998 to October 2019.

Results
Twenty-five studies were identified, 4 on comprehensive frailty scores and 21 on aspects of frailty. Two trials on comprehensive frailty scores showed positive results on frailty although the contribution of medication review in a multidimensional approach was unclear. In the studies on aspects related to frailty, ten individual drug interventions showed improvement in physical performance, muscle strength or body composition utilizing alfacalcidol, teriparatide, piroxicam, testosterone, recombinant human chorionic gonadotropin, or capromorelin. There were no studies examining negative effects of drugs on frailty.

Conclusion
So far, data on a causal relationship between drugs and frailty are inconclusive or related to single-drug interventions on partial aspects of frailty. There is a clear need for RCTs on this topic that should be based on a comprehensive, internationally consistent and thus reproducible concept of frailty assessment.
Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model
Authors: Gutjahr Ralf , Bakker Robbert C. , Tiessens Feiko , van Nimwegen Sebastiaan A. , Schmidt Bernhard , Nijsen Johannes Frank Wilhelmus 
Published: August 2020

Abstract
Objectives
The purpose of this study was to assess the feasibility of dual-energy CT-based material decomposition using dual-X-ray spectra information to determine local concentrations of holmium microspheres in phantoms and in an animal model.

Materials and methods
A spectral calibration phantom with a solution containing 10 mg/mL holmium and various tube settings was scanned using a third-generation dual-energy CT scanner to depict an energy-dependent and material-dependent enhancement vectors. A serial dilution of holmium (microspheres) was quantified by spectral material decomposition and compared with known holmium concentrations. Subsequently, the feasibility of the spectral material decomposition was demonstrated in situ in three euthanized rabbits with injected (radioactive) holmium microspheres.

Results
The measured CT values of the holmium solutions scale linearly to all measured concentrations and tube settings (R2 = 1.00). Material decomposition based on CT acquisitions using the tube voltage combinations of 80/150 Sn kV or 100/150 Sn kV allow the most accurate quantifications for concentrations down to 0.125 mg/mL holmium.

Conclusion
Dual-energy CT facilitates image-based material decomposition to detect and quantify holmium microspheres in phantoms and rabbits.

Key Points
• Quantification of holmium concentrations based on dual-energy CT is obtained with good accuracy.
• The optimal tube-voltage pairs for quantifying holmium were 80/150 Sn kV and 100/150 Sn kV using a third-generation dual-source CT system.
• Quantification of accumulated holmium facilitates the assessment of local dosimetry for radiation therapies.
Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD
Authors: Jenkins Alex R. , Holden Neil S. , Jones Arwel W. 
Published: August 2020

Abstract
Objective
Pulmonary rehabilitation is a cornerstone treatment in the management of chronic obstructive pulmonary disease (COPD). Acute bouts of exercise can lead to short bursts of inflammation in healthy individuals. However, it is unclear how COPD patients respond to acute bouts of exercise. This study assessed inflammatory responses to exercise in COPD patients at the start (phase 1) and end (phase 2) of pulmonary rehabilitation.

Methods
Blood samples were collected before and after an acute exercise bout at the start (phase 1, n = 40) and end (phase 2, n = 27) of pulmonary rehabilitation. The primary outcome was change in fibrinogen concentrations. Secondary outcomes were changes in CRP concentrations, total/differential leukocyte counts, markers of neutrophil activation (CD11b, CD62L and CD66b), and neutrophil subsets (mature, suppressive, immature, progenitor).

Results
Acute exercise (phase 1) did not induce significant changes in fibrinogen (p = 0.242) or CRP (p = 0.476). Total leukocyte count [mean difference (MD), 0.5 ± 1.1 (109 L−1); p = 0.004], neutrophil count [MD, 0.4 ± 0.8 (109 L−1); p < 0.001], and immature neutrophils (MD, 0.6 ± 0.8%; p < 0.001) increased post-exercise. Neutrophil activation markers, CD11b (p = 0.470), CD66b (p = 0.334), and CD62L (p = 0.352) were not significantly altered post-exercise. In comparison to the start of pulmonary rehabilitation (phase 2), acute exercise at the end of pulmonary rehabilitation led to a greater fibrinogen response (MD, 84 mg/dL (95% CI − 14, 182); p = 0.045).

Conclusion
An acute bout of exercise does not appear to induce significant alterations in the concentrations of inflammatory mediators but can increase white blood cell subsets post-exercise. A greater fibrinogen response to acute exercise is seen at the end of pulmonary rehabilitation when compared to the start. Further research is required to understand the clinical context of these acute inflammatory responses to exercise.
Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application
Authors: Gyimesi Gergely , Pujol-Giménez Jonai , Kanai Yoshikatsu , Hediger Matthias A. 
Published: August 2020

AbstractSodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5. This family includes 12 different members in human that mediate the transport of sugars, vitamins, amino acids, or smaller organic ions such as choline. The SLC5 family belongs to the sodium symporter family (SSS), which encompasses transporters from all kingdoms of life. It furthermore shares similarity to the structural fold of the APC (amino acid-polyamine-organocation) transporter family. Three decades after the first molecular identification of the intestinal Na+-glucose cotransporter SGLT1 by expression cloning, many new discoveries have evolved, from mechanistic analysis to molecular genetics, structural biology, drug discovery, and clinical applications. All of these advances have greatly influenced physiology and medicine. While SGLT1 is essential for fast absorption of glucose and galactose in the intestine, the expression of SGLT2 is largely confined to the early part of the kidney proximal tubules, where it reabsorbs the bulk part of filtered glucose. SGLT2 has been successfully exploited by the pharmaceutical industry to develop effective new drugs for the treatment of diabetic patients. These SGLT2 inhibitors, termed gliflozins, also exhibit favorable nephroprotective effects and likely also cardioprotective effects. In addition, given the recent finding that SGLT2 is also expressed in tumors of pancreas and prostate and in glioblastoma, this opens the door to potential new therapeutic strategies for cancer treatment by specifically targeting SGLT2. Likewise, further discoveries related to the functional association of other SGLTs of the SLC5 family to human pathologies will open the door to potential new therapeutic strategies. We furthermore hope that the herein summarized information about the physiological roles of SGLTs and the therapeutic benefits of the gliflozins will be useful for our readers to better understand the molecular basis of the beneficial effects of these inhibitors, also in the context of the tubuloglomerular feedback (TGF), and the renin-angiotensin system (RAS). The detailed mechanisms underlying the clinical benefits of SGLT2 inhibition by gliflozins still warrant further investigation that may serve as a basis for future drug development.
Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk
Authors: Donnelly Christopher R. , Pierchala Brian A. 
Published: August 2020

AbstractThe glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) comprise a group of four homologous and potent growth factors that includes GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). The survival, growth, and mitotic activities of the GFLs are conveyed by a single receptor tyrosine kinase, Ret. The GFLs do not bind directly to Ret in order to activate it, and instead bind with high affinity to glycerophosphatidylinositol (GPI)-anchored coreceptors called the GDNF family receptor-αs (GFRαs). Several mechanisms have recently been identified that influence the trafficking of Ret and GFRαs in and out of the plasma membrane, thereby affecting their availability for ligand binding, as well as their levels by targeting to degradative pathways. This review describes these mechanisms and their powerful effects on GFL signaling and function. We also describe the recent discovery that p75 and Ret form a signaling complex, also regulated by plasma membrane shuttling, that either enhances GFL survival signals or p75 pro-apoptotic signals, dependent on the cellular context.
Prospective randomized controlled trial on comparison of standard CO2 pressure pneumoperitoneum insufflator versus AirSeal®
Authors: Luketina Rosalia , Luketina Theodore L. H. , Antoniou Stavros A. , Köhler Gernot , Könneker Sören , Manzenreiter Lisa , Wundsam Helwig , Koch Oliver Owen , Knauer Michael , Emmanuel Klaus 
Published: August 2020

Abstract
Background
AirSeal® is a valve-free insufflation system that enables a stable pneumoperitoneum with continuous smoke evacuation and CO2 recirculation during laparoscopic surgery. Comparative evidence on the use of AirSeal® and standard CO2 insufflator in laparoscopic general surgery procedures is scarce. The aim of this study was to compare surgical outcomes between AirSeal® and standard CO2 insufflators in patients undergoing the most frequently performed laparoscopic procedures.

Methods
One hundred and ninety-eight patients undergoing elective laparoscopic cholecystectomy, colorectal surgery and hernia repair were randomized to either AirSeal® (group A) or standard pressure CO2 insufflator (group S). The primary endpoints were operative time and level of postoperative shoulder tip pain (Visual Analog Scale). Secondary outcomes included Clavien–Dindo grade complications, surgical side effect and length of hospital stay.

Results
Patients were randomized to either group A (n = 101) or group S (n = 97) and were analyzed by intention-to-treat. There was no significant difference in mean operative time between the groups (median [IQR]; 71 min [56–94] in group A vs. 69 min [52–93] in group S; p = 0.434). Shoulder tip pain levels were significantly lower in group S (VAS 0 [0–3] in group S vs. 2 [0–4] in group A; p = 0.001). There was no significant difference in complications, surgical side effects (subcutaneous emphysema was not observed in any group) and length of hospital stay.

Conclusion
This randomized controlled trial showed that using the AirSeal® system did not reduce operative time and was associated with a higher postoperative shoulder tip pain compared to standard CO2 insufflator for short elective surgeries.
ClinicalTrials.gov (NCT01740011).
Population-based Tabu search with evolutionary strategies for permutation flow shop scheduling problems under effects of position-dependent learning and linear deterioration
Authors: Arık Oğuzhan Ahmet 
Published: August 2020

AbstractThis paper investigates permutation flow shop scheduling (PFSS) problems under the effects of position-dependent learning and linear deterioration. In a PFSS problem, there are n jobs and m machines in series. Jobs are separated into operations on $$ m $$
m
different machines in series, and jobs have to follow the same machine order with the same sequence. The PFSS problem under the effects of learning and deterioration is introduced with a mixed-integer nonlinear programming model. The time requirement for solving large-scale problems type of PFSS problem is exceedingly high. Therefore, well-known metaheuristic methods for the PFSS problem without learning and deterioration effects such as iterated greedy algorithms and discrete differential evolution algorithm are adapted for the problem with learning and deterioration effects in order to find a faster and near-optimal or optimal solution for the problem. Furthermore, this paper proposes a hybrid solution algorithm that is called population-based Tabu search algorithm (TSPOP) with evolutionary strategies such as crossover and mutation. The search algorithm is built on the basic structure of Tabu search and it searches for the best candidate from a solution population instead of improving the current best candidate at each iteration. Furthermore, the performances of these methods in view of solution quality are discussed in this paper by using test problems for 20, 50, and 100 jobs with 5, 10, 20 machines. Experimental results show that the proposed TSPOP algorithm outperforms the other existing algorithms in view of solution quality.
Irrelevance of Panton-Valentine leukocidin in hidradenitis suppurativa: results from a pilot, observational study
Authors: Corazza Monica , Borghi Alessandro , Bettoli Vincenzo , Pora Roberto , Bononi Ilaria , Mazzoni Elisa , Mazzola Elisa , Saraceni Silva , Maritati Martina , Contini Carlo 
Published: August 2020

AbstractPanton-Valentine leukocidin (PVL) appears to be a virulence factor which, among others, can exacerbate the pathogenicity of Staphylococcus aureus infections, especially inducing severe necrotic, deep-seated skin infections, abscesses, and recurrences. These peculiarities have some overlaps with hidradenitis suppurativa (HS). Our main aim was to assess if S. aureus producing PVL could have some role in influencing clinical features and/or course of HS, specifically in the suppuration and recurrence of lesions. This pilot, mono-centric, observational study included all adult subjects affected with HS consecutively referring to our HS clinic over a 3-month period. Clinically evident suppuration and at least 2 weeks wash out from any antibiotic were the main inclusion criteria. Purulent material from HS skin lesions was collected with swabs in order to isolate micro-organisms, with specific regard to S. aureus. Detection of PVL was performed by real-time quantitative PCR (RT-qPCR). We also analyzed purulent material from suppurative skin lesions other than HS, as a control. Thirty HS patients were included; 29 purulent lesions (96.7%) harbored at least one bacterial species. Five (16.7%) swab samples were positive for S. aureus, none of which was positive for PVL genes. Among the 30 purulent disorders included as controls, 8 (26.3%) were positive for S. aureus; of these, 4 strains (50%) expressed LPV. The study results seem to exclude the pathogenetic involvement of S. aureus producing PVL in HS; as a result, PVL does not seem to represent a potential target in the future development of HS treatments.
An advanced residual error model for tropospheric delay estimation
Authors: Rózsa Szabolcs , Ambrus Bence , Juni Ildikó , Ober Pieter Bastiaan , Mile Máté 
Published: August 2020

AbstractGlobal navigation satellite systems (GNSS) are widely used for safety-of-life positioning applications. Such applications require high integrity, availability, and continuity of the positioning service. Integrity is assessed by the definition of a protection level, which is an estimation of the maximum positioning error at extremely low probability levels. The emergence of multi-frequency civilian signals and the availability of satellite-based augmentation systems improve the modeling of ionospheric disturbances considerably. As a result, in many applications the tropospheric delay tends to become one of the limiting factors of positioning—especially at low elevation angles. The currently adopted integrity concepts employ a global constant to model the variance of the residual tropospheric delay error. We introduce a new approach to derive residual tropospheric delay error models using the extreme value analysis technique. Seventeen years of global numerical weather model fields are analyzed, and new residual error models are derived for some recently developed tropospheric delay models. Our approach provides models that consider both the geographical location and the seasonal variation of meteorological parameters. Our models are validated with a 17-year-long time series of zenith tropospheric delay estimates as provided by the International GNSS Service. The results show that the developed models are still conservative, while the maximal residual error of the tropospheric delay is still improved by 39–55%. This improvement yields higher service availability and continuity in safety-of-life applications of GNSS.
Intergroup food transfers in wild golden lion tamarins (Leontopithecus rosalia)
Authors: Troisi Camille A. 
Published: August 2020

AbstractThe transfer of food between adults is uncommon in primates. Although golden lion tamarins (Leontopithecus rosalia) are unique among primates in the extent to which they transfer food, reports of food transfers between adults have so far been restricted to captive or reintroduced individuals. Here, I report the first recorded events of adult–adult food transfers in golden lion tamarins between individuals belonging to different groups in the wild. Given that individuals emigrate from their natal group to find reproductive opportunities, I suggest that intergroup food transfers could be a way for individuals to estimate the quality or availability of potential mates or social partners. I propose an additional function of food transfers in wild golden lion tamarins: that they create and strengthen social bonds with individuals outside of the family group.
A Stable Dendritic Growth with Forced Convection: A Test of Theory Using Enthalpy-Based Modeling Methods
Authors: Kao A. , Toropova L. V. , Krastins I. , Demange G. , Alexandrov D. V. , Galenko P. K. 
Published: August 2020

AbstractThe theory of stable dendritic growth within a forced convective flow field is tested against the enthalpy method for a single-component nickel melt. The growth rate of dendritic tips and their tip diameter are plotted as functions of the melt undercooling using the theoretical model (stability criterion and undercooling balance condition) and computer simulations. The theory and computations are in good agreement for a broad range of fluid velocities. In addition, the dendrite tip diameter decreases, and its tip velocity increases with increasing fluid velocity.
High-Resolution Manometry—Observations After 15 Years of Personal Use—Has Advancement Reached a Plateau?
Authors: Sweis Rami , Fox Mark 
Published: August 2020

Abstract
Purpose of Review
In the absence of mucosal or structural disease, the aim of investigating the oesophagus is to provide clinically relevant measurements of function that can explain the cause of symptoms, identify pathology and guide effective management. One of the most notable recent advances in the field of oesophageal function has been high-resolution manometry (HRM). This review explores how innovation in HRM has progressed and has far from reached a plateau.

Recent Findings
HRM technology, methodology and utility continue to evolve; simple additions to the swallow protocol (e.g. eating and drinking), shifting position, targeting symptoms and adding impedance sensors to the HRM catheter have led to improved diagnoses, therapeutic decision-making and outcomes.

Summary
Progress in HRM persists and shows little sign of abating. The next iteration of the Chicago Classification of motor disorders will highlight these advances and will also identify opportunities for further research and innovation.
Design Of Lunar-Gravity-Assisted Escape Trajectories
Authors: Casalino Lorenzo , Lantoine Gregory 
Published: August 2020

AbstractLunar gravity assist is a means to boost the energy and C3 of an escape trajectory. Trajectories with two lunar gravity assists are considered and analyzed. Two approaches are applied and tested for the design of missions aimed at Near-Earth asteroids. In the first method, indirect optimization of the heliocentric leg is combined to an approximate analytical treatment of the geocentric phase for short escape trajectories. In the second method, the results of pre-computed maps of escape C3 are employed for the design of longer Sun-perturbed escape sequences combined with direct optimization of the heliocentric leg. Features are compared and suggestions about a combined use of the approaches are presented. The techniques are efficiently applied to the design of a mission to a near-Earth asteroid.