bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controversial Industries, Regional Differences, and Risk: Role of CSR*
Authors: Jo Hoje , Park Kwangwoo 
Published: January 2021

AbstractControversial industries such as the alcohol, gambling, tobacco, and firearms sectors have long suffered from organizational legitimacy problems. Using data covering 32 countries, we show that controversial industry firms’ engagement in CSR initiatives has a substantial risk‐decreasing effect, thereby increasing the probability of maintaining the social license to operate. The effect of CSR on firm risk, however, is more pronounced for firms in Europe and North America than in the Asia‐Pacific region, suggesting that the CSR–risk association varies by region. Our results are consistent with the view of the “social license to operate” and the “differential recognition” hypotheses.
Pubectomy and urinary reconstruction provides definitive treatment of urosymphyseal fistula following prostate cancer treatment
Authors: Andrews Jack R. , Hebert Kevin J. , Boswell Timothy C. , Avant Ross A. , Boonipatt Thanapoom , Kreutz‐Rodrigues Lucas , Bakri Karim , Houdek Matthew T. , Karnes R. Jeffery , Viers Boyd R. 
Published: January 2021

ObjectiveTo describe the natural history, reconstructive solutions, and functional outcomes of those men undergoing pubectomy and urinary reconstruction after prostate cancer treatment.Patients and MethodsThis study retrospectively identified 25 patients with a diagnosis of urosymphyseal fistula (UF) following prostate cancer therapy who were treated with urinary reconstruction with pubectomy. This study describes the natural history, reconstructive solutions, and functional outcomes of this cohort.ResultsAll 25 patients had a history of pelvic radiotherapy for prostate cancer. The median (interquartile range [IQR]) time from prostate cancer treatment to diagnosis of UF was 11 (6, 16.5) years. The vast majority of men (24/25; 96%) presented with debilitating groin pain during ambulation. Posterior urethral stenosis was common (20/25; 80%), with 60% having repetitive endoscopic treatments. Culture of pubic bone specimens demonstrated active infection in 80%. Discordance between preoperative urine and intraoperative bone cultures was common, 21/22 (95.5%). After surgery, major 90‐day complications (Clavien–Dindo Grade III and IV) occurred in eight (32%) patients. Pain was significantly improved, with resolution of pain (24/25; 96%) and restoration of function, the median (IQR) preoperative Eastern Cooperative Oncology Group Performance Status (ECOG PS) was 3 (2, 3) vs median postoperative ECOG PS score of 0 (0, 1).ConclusionEndoscopic urethral manipulation after radiation for prostate cancer is a risk factor for UF. Conservative management will not provide symptom resolution. Fistula decompression, bone resection, and urinary reconstruction effectively treats chronic infection, improves pain and ECOG PS scores.
Community‐based sugar‐sweetened beverage intervention associated with short‐term improvements in self‐rated oral health
Authors: Wang Monica L. , Minyé Helena M. , Egan Kelsey A. , Heaton Brenda 
Published: January 2021

AbstractObjectivesTo assess the efficacy of a community‐based childhood obesity prevention intervention targeting Sugar‐sweetened beverage (SSB) consumption on self‐rated oral health among children and their parents/caregivers.MethodsThis study is a secondary analysis of data from a pilot site‐randomized intervention (H2GO!) targeting SSB consumption and obesity risk among children. The 6‐week SSB behavioural intervention was implemented in two Massachusetts Boys and Girls Club sites that were matched for size and racial/ethnic composition. Children ages 9‐12 years and their parents/caregivers were eligible to participate. Data on self‐rated oral health and sociodemographics were obtained via self‐report surveys at baseline, 2 and 6 months. Generalized linear mixed regression models were used to estimate 2‐ and 6‐month change in oral health associated with the intervention.ResultsData are from 100 child participants (46% female; 38% Black, 20% Hispanic, 13% White, 12% Multiracial, 11% Asian) and 87 parent participants (78.2% female; 37.9% Hispanic, 29.9% Black, 14.9% Asian, 10.3% White). At baseline, 47% of child participants rated their oral health as good, followed by very good (32%), fair (11%) and excellent (10%). Among parents, 46.3% rated their oral health as good, followed by very good (29.3%), excellent (9.8%), fair (9.7%) and poor (4.9%). The intervention was associated with 2‐ and 6‐month improvements in child participants' mean self‐rated oral health scores (β = 0.78; 95% CI: 0.48, 1.087;P < .001; β = 0.98; 95% CI: 0.61, 1.34;P < .001, respectively) and with 2‐month improvements in parent participants' mean self‐rated oral health (β = 0.42; 95% CI: 0.016, 0.82;P = .042).ConclusionShort‐term improvements in oral health among children and their parents/caregivers were observed among those participating in a SSB behavioural intervention. Community‐based behavioural programmes targeting SSB consumption may be a promising approach to promote oral health as well as prevent childhood obesity.
Neurovascular Unit: A critical role in ischemic stroke
Authors: Wang Liyun , Xiong Xiaoxing , Zhang Luyuan , Shen Jian 
Published: January 2021

AbstractIschemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS.
Comparative bioinformatics analysis between proteomes of rabbit aneurysm model and human intracranial aneurysm with label‐free quantitative proteomics
Authors: Liu Yingjun , Song Yaying , Liu Peixi , Li Sichen , Shi Yuan , Yu Guo , Quan Kai , Fan Zhiyuan , Li Peiliang , An Qingzhu , Zhu Wei 
Published: January 2021

AbstractAimsThis study aimed to find critical proteins involved in the development of intracranial aneurysm by comparing proteomes of rabbit aneurysm model and human aneurysms.MethodsFive human intracranial aneurysm samples and 5 superficial temporal artery samples, and 4 rabbit aneurysm samples and 4 control samples were collected for protein mass spectrometry. Four human intracranial aneurysm samples and 4 superficial temporal artery samples, and 6 rabbit aneurysm samples and 6 control samples were used for immunochemistry.ResultsProteomic analysis revealed 180 significantly differentially expressed proteins in human intracranial aneurysms and 716 significantly differentially expressed proteins in rabbit aneurysms. Among them, 57 proteins were differentially expressed in both species, in which 24 were increased and 33 were decreased in aneurysms compared to the control groups. Proteins were involved in focal adhesion and extracellular matrix‐receptor interaction pathways. We found that COL4A2, MYLK, VCL, and TAGLN may be related to aneurysm development.ConclusionProteomics analysis provided fundamental insights into the pathogenesis of aneurysm. Proteins related to focal adhesion and extracellular matrix‐receptor interaction pathways play an important role in the occurrence and development of intracranial aneurysm.
Gesture Helps, Only If You Need It: Inhibiting Gesture Reduces Tip‐of‐the‐Tongue Resolution for Those With Weak Short‐Term Memory
Authors: Pyers Jennie E. , Magid Rachel , Gollan Tamar H. , Emmorey Karen 
Published: January 2021

AbstractPeople frequently gesture when a word is on the tip of their tongue (TOT), yet research is mixed as to whether and why gesture aids lexical retrieval. We tested three accounts: the lexical retrieval hypothesis, which predicts that semantically related gestures facilitate successful lexical retrieval; the cognitive load account, which predicts that matching gestures facilitate lexical retrieval only when retrieval is hard, as in the case of a TOT; and the motor movement account, which predicts that any motor movements should support lexical retrieval. In Experiment 1 (a between‐subjects study;N = 90), gesture inhibition, but not neck inhibition, affected TOT resolution but not overall lexical retrieval; participants in the gesture‐inhibited condition resolved fewer TOTs than participants who were allowed to gesture. When participants could gesture, they produced more representational gestures during resolved than unresolved TOTs, a pattern not observed for meaningless motor movements (e.g., beats). However, the effect of gesture inhibition on TOT resolution was not uniform; some participants resolved many TOTs, while others struggled. In Experiment 2 (a within‐subjects study;N = 34), the effect of gesture inhibition was traced to individual differences in verbal, not spatial short‐term memory (STM) span; those with weaker verbal STM resolved fewer TOTs when unable to gesture. This relationship between verbal STM and TOT resolution was not observed when participants were allowed to gesture. Taken together, these results fit the cognitive load account; when lexical retrieval is hard, gesture effectively reduces the cognitive load of TOT resolution for those who find the task especially taxing.
Chronic transplant glomerulopathy: New insights into pathogenesis
Authors: Gokhale Avantee , Chancay Jorge , Shapiro Ron , Randhawa Parmjeet , Menon Madhav C. 
Published: January 2021

AbstractThere have been recent significant advances in short‐term outcomes in renal transplantation, however, long‐term allograft survival remains a challenge. With reported incidences as high of 74.5% of chronic graft loss in patients with biopsies showing transplant glomerulopathy (TG), this syndrome represents an important factor for chronic allograft complications. In this review we show an overview of the novel mechanistic insights into pathogenesis of TG, as well as a brief description of the pathology, diagnosis and newer prognostic indices within TG diagnosis. These data raise intriguing roles for cell‐mediated immunity and podocyte stress in TG as well as reinforce previous associations of TG with ABMR. We also delve into management strategies for TG and report the paucity of existing clinical trial data for this prevalent condition in renal transplants.
Drug‐induced psoriasiform alopecia associated with interleukin‐17 inhibitor therapy
Authors: Tan Timothy L. , Taglia Lauren , Yazdan Pedram 
Published: January 2021

AbstractDrug‐induced psoriasiform alopecia is an increasingly recognized form of alopecia mostly reported in association with TNF‐alpha inhibitors. However, drug‐induced psoriasiform alopecia in association with IL‐17A inhibitors has not been described. We present a 62‐year‐old woman with severe psoriasis who developed new psoriatic plaques on the scalp with alopecia after initiating ixekizumab (anti‐IL‐17A). Scalp biopsy specimens revealed a non‐cicatricial alopecia with increased telogen/catagen follicles, atrophy of the sebaceous glands, peribulbar and perifollicular inflammation with frequent lymphocytes, plasma cells, eosinophils, psoriasiform dermatitis, and lack of intra‐corneal or intra‐epidermal neutrophils. Overall, the clinical and histopathologic findings were most compatible with a drug‐induced psoriasiform alopecia in association with IL‐17A inhibitor therapy. Our case shows that drug‐induced psoriasiform alopecia can paradoxically occur in patients on IL‐17A inhibitor therapy and contributes to the growing list of cutaneous eruptions associated with biologic agents.
Non‐linear reduction of photosynthetic ability in oak trees infected with Tubakia koreana causing Quercus leaf blight
Authors: Park Minjee , Yun Hye Young , Kim Young Ho , Kim Kunhyo , Kim Hyun Seok 
Published: January 2021

AbstractTubakia species are fungi causing leaf spots and blights and are reported worldwide, mainly in Asia, Europe and North America. These diseases often occur on Quercus (oak) trees, which constitute one of the dominant broad‐leaved tree genera in the world, so forest structure, function and dynamics could be affected by Tubakia infection. However, few data about the negative impacts of Tubakia on key leaf functional traits are available. This study was conducted to investigate the changes in photosynthetic capacity, morphological, and chemical traits of sawtooth oak (Quercus acutissima Carruth.) leaves infected with Tubakia koreana causing Quercus leaf blight. Two control and four treatment seedlings were used for this study. It was found that maximum photosynthetic rate and maximum rates of carboxylation and electron transport showed exponential reductions with increasing disease severity (p < .001). However, leaf mass per area (LMA) showed no noticeable changes, while leaf nitrogen concentration (Nmass) increased linearly with increasing disease severity (p < .001), suggesting that Tubakia disease may underlay the inconsistent patterns of LMA and Nmass. These findings contribute to the understanding of fundamental effects of disease development on physiological traits of oak leaves.
Demographic consequences of foraging ecology explain genetic diversification in Neotropical bird species
Authors: Miller Matthew J. , Bermingham Eldredge , Turner Benjamin L. , Touchon Justin C. , Johnson Andrew B. , Winker Kevin 
Published: January 2021

AbstractDespite evidence that species’ traits affect rates of bird diversification, biogeographic studies tend to prioritise earth history in Neotropical bird speciation. Here we compare mitochondrial genetic differentiation among 56 co‐distributed Neotropical bird species with varying ecologies. The trait ‘diet’ best predicted divergence, with plant‐dependent species (mostly frugivores and nectivores) showing lower levels of genetic divergence than insectivores or mixed‐diet species. We propose that the greater vagility and demographic instability of birds whose diets rely on fruit, seeds, or nectar  known to vary in abundance seasonally and between years  relative to birds that eat primarily insects, drives episodic re‐unification of otherwise isolated populations, resetting the divergence ‘clock’. Testing this prediction using coalescent simulations, we find that plant‐dependent species show stronger signals of recent demographic expansion compared to insectivores or mixed‐diet species, consistent with this hypothesis. Our study provides evidence that localised ecological phenomena scale up to generate larger macroevolutionary patterns.
Quantitative estimates of freshwater fish stocking practices by recreational angling clubs in France
Authors: Cucherousset Julien , Lassus Rémy , Riepe Carsten , Millet Paul , Santoul Frédéric , Arlinghaus Robert , Buoro Mathieu 
Published: January 2021

AbstractAlthough freshwater fish stocking is widely used by managers, quantitative assessments of stocking practices are lacking in many countries. The general objective of the present study was to determine the quantity and characteristics of fish stocking in metropolitan France. Using a survey‐based approach, stocking practices for 2013 by recreational angling clubs in France were quantified, which represented the bulk of fish stocking undertaken in that year. Stocking was found to be practiced by 88.6% of angling clubs in France, representing, on average, 65% of their annual budget. Overall, 22 species were stocked, including 13 native and nine non‐native species, with strong variations among species in terms of life stages and body sizes used for stocking. Using Bayesian modelling, a total biomass of 2.029 t, representing approximately 90 million fishes, was estimated to be stocked in France in 2013. In terms of biomass, the most widely stocked species were rainbow troutOncorhynchus mykiss(Walbaum), brown troutSalmo truttaL., roachRutilus rutilus(L.), common carpCyprinus carpioL. and northern pikeEsox luciusL. A stocking volume of approximately 60 fishes or 1.5 kg of fish biomass per angler per year seems commonplace in industrialised countries for which data are available.
Performance evaluation of the new hematology analyzer UniCel DxH 900
Authors: Martinez‐Iribarren Alicia , Tejedor Xavier , Sala Sanjaume Àngels , Leis Alba , Doladé Botias Maria , Morales‐Indiano Cristian 
Published: January 2021

AbstractIntroductionUniCel DxH900 (Beckman Coulter, Miami, Florida, USA) is a quantitative, multi‐parameter, automated hematology analyzer for in vitro diagnostic use in clinical laboratories. The aim of this study was to evaluate the analytical performance of the new DxH900 analyzer to verify its diagnostic and clinical utility in the hematology laboratory of a tertiary care hospital in Spain. The most important and novel feature offered by DxH900 analyzer is providing MDW (monocyte distribution width), a new hematologic parameter which is being clinically validated as an early sepsis indicator with promising results.MethodsWe evaluated imprecision (including MDW), linearity, and carryover of DxH900. Method comparison for cell blood count (CBC) was performed in relation to DxH800 with 100 samples. We compared leukocyte differential (DIFF) from DxH900 with manual 400‐cell differential. 390 samples were assessed for flag performance.ResultsResults obtained for between days and within‐run imprecision were good. DxH900 showed excellent linearity (R = 1.00) over analytical range for white blood cells, red blood cells, hemoglobin, platelets, and reticulocyte count (RET) (R = 0.96) and no significant carryover effect. CBC and RET on the DxH900 correlated well with DxH800 (R ≥ 0.99). Comparison with manual differential showed excellent correlation (R ≥ 0.88), except for basophils. Flagging performance exhibited sensitivity over 90% for majority of alarm messages and very high negative predictive value (over 95%).ConclusionUniCel DxH900 Coulter analyzer provides reliable results and fully comparable to DxH800. DxH900 is an accurate, highly precise analyzer with good analytical performances to be used effectively in high‐volume laboratories.
Variations in blood pressure control by medical comorbidities prior to sudden death
Authors: Keen Susan K. , Chang Albert , Gupta Suhani , Lin Feng‐Chang , Simpson Ross J. 
Published: January 2021

AbstractPatients with hypertension have increased risk of sudden death, but the impact of blood pressure control in sudden death is not clear. To better understand potential opportunities to prevent sudden, we assessed blood pressure control, comorbidities, and the number of recent medical encounters among all‐cause sudden death victims. Less than 40% of sudden death victims with hypertension had controlled blood pressure prior to death. Furthermore, increased frequency of medical visits and number of comorbidities were associated with better blood pressure control Strategies to address clinical inertia in hypertension treatment particularly for patients with fewer comorbidities may attenuate the risk of sudden death.
Recent, small beginnings: genetic analysis suggests Catostomus rimiculus (Klamath smallscale sucker) in the Smith River, California, are introduced
Authors: Kinziger Andrew P. , White Jason L. , Nakamoto Rodney J. , Harvey Bret C. 
Published: January 2021

AbstractIdentification of introduced species can be important to understanding ecological systems and meeting conservation and management goals, but the process can be surprisingly challenging. The Klamath smallscale sucker Catostomus rimiculus seems likely to be native to the Smith River because the drainage separates two basins believed to be within the fish's native range, the Rogue and Klamath rivers. Further, C. rimiculus is broadly distributed in the Smith River, and the indigenous Dee‐ni’ People of the Smith River have a unique word for sucker. Nonetheless, a historical survey of fishes that described C. rimiculus from the Rogue and Klamath rivers did not include C. rimiculus among the fishes of the Smith River. To determine whether the genetic structure of the Smith River C. rimiculus reflects expectations for a native sucker population, the authors of this study examined variation in microsatellite and mitochondrial genetic markers from the Smith River and surrounding drainages. The genetic analyses revealed a pattern consistent with extreme founder effects in Smith River C. rimiculus, as would be expected from a single introduction of six or fewer effective individuals. The sharing of a high‐frequency haplotype between the Smith River and Klamath River that is not detected in the Rogue River suggests the Klamath River as the likely source for the introduction. The findings highlight that local‐scale introductions can be easily overlooked because the newly established populations can appear to be parts of contiguous natural distributions.
Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
Authors: Seeger Drew R. , Golovko Svetlana A. , Grove Bryon D. , Golovko Mikhail Y. 
Published: January 2021

AbstractAlthough cyclooxygenase (COX) role in cancer angiogenesis has been studied, little is known about its role in brain angioplasticity. In the present study, we chronically infused mice with ketorolac, a non‐specific COX inhibitor that does not cross the blood–brain barrier (BBB), under normoxia or 50% isobaric hypoxia (10% O2 by volume). Ketorolac increased mortality rate under hypoxia in a dose‐dependent manner. Using in vivo multiphoton microscopy, we demonstrated that chronic COX inhibition completely attenuated brain angiogenic response to hypoxia. Alterations in a number of angiogenic factors that were reported to be COX‐dependent in other models were assayed at 24‐hr and 10‐day hypoxia. Intriguingly, hypoxia‐inducible factor 1 was unaffected under COX inhibition, and vascular endothelial growth factor receptor type 2 (VEGFR2) and C‐X‐C chemokine receptor type 4 (CXCR4) were significantly but slightly decreased. However, a number of mitogen‐activated protein kinases (MAPKs) were significantly reduced upon COX inhibition. We conclude that additional, angiogenic factor‐independent mechanism might contribute to COX role in brain angioplasticity, probably including mitogenic COX effect on endothelium. Our data indicate that COX activity is critical for systemic adaptation to chronic hypoxia, and BBB COX is essential for hypoxia‐induced brain angioplasticity. These data also indicate a potential risk for using COX inhibitors under hypoxia conditions in clinics. Further studies are required to elucidate a complete mechanism for brain long‐term angiogenesis regulation through COX activity.
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