bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Substance Abuse on the Roles and Occupations of Women with Substance Use Disorders.
Authors: Rawat Humayra , Petzer Stacey Lisa , Gurayah Thavanesi 
Published: February 2025

Authors:Â Rawat,HÂ ;Petzer, S.L. ;Gurayah,T.Â Ethical Clearance Number:Â HSS/0199/018HÂ Affiliation:Â School of Health Sciences, University of Kwa-Zulu NatalÂ Introduction:Literature regarding the psychosocial sequelae of substance abuse is largely androcentric and limited regarding the negative effects on women's functioning. This study aims to explore the effects of substance abuse on the roles and occupations of women.Â Methods:This phenomenological qualitative study utilized a purposive snowball sampling strategy to recruit women with a history of substance abuse. Semi-structured interviews were conducted with six participants.Â Findings:Six main themes emerged. The themes alluded to the participants' neglect of self-care, sleep, and IADL (instrumental activities of daily living) responsibilities. They were socially isolated, and their work lives suffered because of their substance abuse.Â Conclusion:The study concluded that substance abuse negatively affects a woman's ability to engage in her daily occupations and unique roles. Inadequate self-care, debt, neglect of child-rearing roles and work underperformance were some consequences of their abuse. However, it was found that the adoption of new roles associated with advocacy and altruism facilitated the recovery process. The findings can be used to create gender specific interventions for women with substance use disorders.
Reseña. Jesús G. MAESTRO, Calipso eclipsada. El teatro de Cervantes más allá del Siglo de Oro, Madrid, Editorial Verbum, 2013, 316 páginas
Authors: Maire Bobes Jesús 
Published: February 2025

Reseña del libro: Jesús G. Maestro, Calipso eclipsada. El teatro de Cervantes más allá del Siglo de Oro, Madrid, Editorial Verbum, 2013, 316 págs, ISBN 978-84-7962-899-4.
Adaptación de grabados de Hans Holbein para la Cárcel de amor (Zaragoza, Esteban de Nájera, 1551)
Authors: Marín Pina M.ª Carmen 
Published: February 2025

En la dilatada trayectoria editorial de la Cárcel de amor de Diego de San Pedro en el siglo XVI, el texto permanece siempre fiel, pero en las sucesivas ediciones el libro va cambiando de formato, de letra y de ilustraciones. En 1551, en la imprenta zaragozana de Esteban de Nájera se publica una edición en 8º totalmente renovada en su programa iconográfico. El presente artículo estudia el origen de sus xilografías y su adaptación al texto. Parte de los grabados que ilustran esta edición tardía son copias de dibujos del pintor alemán Hans Holbein el viejo (1497-1543), en concreto de las series diseñadas para ilustrar las Historiarum Veteris Instumenti Icones y la Danza de la Muerte. Las fuentes que pudo manejar el entallador de las copias pudieron ser los Retratos o tablas del Testamento Viejo (Lyon, 1543) y Les Images de la Mort (Lyon, 1547).
Reseña. Pedro Calderón de la Barca, La cisma de Ingalaterra, edición de Juan Manuel Escudero Baztán, Madrid, Cátedra, 2018
Authors: Handal Ortiz Leonel Demetrio 
Published: February 2025

Una reseña sobre la nueva edición y aparato crítico de La cisma de Ingalaterra de Pedro Calderón de la Barca, a cargo del catedrático e investigador del GRISO Juan Manuel Escudero Baztán.
Sobre la edición del Tratado de la artillería y uso della platicado por el capitán Diego Ufano en las guerras de Flandes (1612-1613)
Authors: De la Fuente de Pablo Pablo 
Published: February 2025

El tratado de Ufano es el mejor libro sobre artillería del siglo XVII. Hoy en día, es una referencia fundamental en los estudios de armamento de esta época. Sin embargo, una de las razones de su éxito fue su proceso editorial. El estudio del Tratado de la artillería (1612-1613) como producto cultural es el objetivo de este artículo. En relación a este tema, el papel desarrollado por el impresor flamenco Jan Mommaert fue esencial.
Comprehensive Analysis of Knee Joint Mobilization Skills in Physical Therapy Education: Validity and Reliability of On-Site and Off-Site Direct Observation of Procedural Skills (DOPS)
Authors: Hou Yu-Jen , Liu Wen-Yu , Hsieh Ming-Ju , Lien Hen-Yu , Wang Tzyy-Jiuan , Cheng Chih-Hsiu , Yau Sze-Yuen , Lin Yang-Hua 
Published: February 2025

Abstract

Background: The direct observation of procedural skills for knee joint mobilization (DOPSknee) tool requires validation to ensure its reliability and validity for providing immediate feedback and assessing its applicability in off-site settings. We aimed to describe the implementation and clinimetric properties of DOPSknee in both on-site and off-site environments, as well as to evaluate the preclinical competencies of physical therapy (PT) students.
Methods: Following the development of DOPSknee, 42 preclinical PT students were filmed performing knee joint mobilization. Their performance was assessed by two clinical instructors using DOPSknee, in on-site and off-site conditions, with an interval of 1.5–4.5 months between assessments.
Results: DOPSknee exhibited good on-site inter-rater reliability (ICC = 0.78). However, it had poor off-site inter-rater reliability (ICC = 0.37) and intra-rater reliability differed substantially between on- and off-site evaluations (evaluator 1: ICC = 0.42; evaluator 2: ICC = 0.88). Nevertheless, DOPSknee exhibited good reliability for average measures from on- and off-site evaluations (ICC = 0.84). Average total DOPSknee scores were significantly correlated with average global rating scores in both on-site (r = 0.47) and off-site conditions (r = 0.75), as well as in cross-over conditions (r = 0.54 and 0.71). The cutoff score for DOPSknee was determined to be 14 points. Construct validity analysis of both on- and off-site evaluations revealed that students who passed the DOPSknee evaluation had significantly higher average global rating scores (p < 0.05).
Conclusions: DOPSknee exhibited good validity and reliability for assessing student performance in on-site conditions. However, caution is recommended when interpreting off-site results. Using average measures may improve reliability in off-site assessments.
Loading of a porous rock with constant micro-seismic event rate suppresses seismicity and promotes subcritical failure
Authors: Mangriotis Maria-Daphne , Cartwright-Taylor Alexis , Main Ian , Curtis Andrew , Bell Andrew , Butler Ian B. , Fusseis Florian 
Published: February 2025

Abstract

Catastrophic failure is the end result of progressive localisation of damage creating brittle failure on a variety of system scales in the Earth. However, the factors controlling this evolution, and the relationship between deformation and the resulting earthquake hazard, are not well constrained. Here we address the question of how to adapt operational controls in a strain-inducing laboratory experiment so as to minimize associated microseismicity. We simultaneously image the induced damage using x-rays at a synchrotron, and detect acoustic emissions which can be fed back to change operational controls on the experiment. We confirm that using continuous servo-control based on acoustic emission event rate not only slows down deformation compared to standard constant strain rate loading, but also suppresses events of all sizes, including extreme events. We develop a new model that explains this observation, based on the observed evolution of microstructural damage and the fracture mechanics of subcritical crack growth. The model is independently consistent with the observed stress history and acoustic emission statistics. Our results imply that including seismic event rate control may improve risk management of induced seismicity over a range of event magnitudes, if similar processes are relevant at larger scales.
A Population-Based Cohort to Investigate the Impact of COVID-19 on Socioeconomic Inequalities in Mental Health Care in Italy (Comeh): Study Protocol
Authors: Petrelli Alessio , Aragona Massimiliano , Ciampichini Roberta , Napoli Anteo Di , Fano Valeria , Leone Sara , Pacifici Martina , Rosini Claudio , Silvestri Caterina , Zucchi Alberto , Ventura Martina 
Published: February 2025

Abstract

Purpose
The CoMeH cohort was established to assess the impact of the COVID-19 pandemic on the use of mental health services in Italy in the short and long term, with a particular focus on socioeconomic and/or citizenship inequalities.
Methods
All residents subjects for at least 2 years, aged ≥ 10 years, and assisted by an NHS general practitioner (GP) of the area of residence, in three vast catchment areas (N = 5,167,043). Primary outcomes of interest are the following indicators of mental health care services’ use: first access to any mental health care service, total number of accesses to mental health care services, the consumption of psychiatric drugs, the number of psychiatric or psychological outpatient visits, the number of residential or day care days spent in psychiatric facilities, the number of emergency and/or inpatient admissions to hospitals.
Results
Incident users were 3.2% of the population for Bergamo LHA, 3.5% for Rome2 LHA, and 4.4% for the Tuscany Region. The overall crude incidence rate of access to mental health care was 3.3% in the pre-COVID-19 period and 2.6% during the pandemic. Prescriptions for a mental disorder (57.2%) and ED admissions (25.1%) were the main reasons for enrollment. Compared to the general population, people with mental health conditions were older and more often female. The distribution of the incident users by deprivation index overlapped that of the population. Immigrants were younger, socioeconomically more deprived, and more often entered the study for an ED admission.
Conclusion
We will focus on the impact of the pandemic through the evaluation of accesses to hospitalization, emergency, outpatient visits, residential and day care services, and drug prescriptions. We will also evaluate socioeconomic inequalities through the use of census-based deprivation index and migration status. Finally, we will also analyze the impact of COVID-19 infection and outcome on the study cohort.
Differences between behavioral time budget and welfare indicators in two different slow-growing broiler genotypes kept in the free-range system
Authors: Sozcu Arda , Ipek Aydın , Gunnarsson Stefan 
Published: February 2025

Abstract

The consumer interest for meat from slow growing broilers in free-range system has increased recently. Therefore, the need for knowledge about behaviour and welfare of birds in these systems has increased. The aim of this study was to compare the differences between behavioral time budget, and clinical welfare indicators in two slow growing broiler genotypes (Hubbard ISA Red JA-57 and Sasso XL44 × SA51A) kept in a free-range system. In total of 480 one-day old chicks were reared, and the birds were regularly scored for behavioral time budget and multiple welfare indicators. The eating and drinking showed a decreasing tendency in Sasso birds, whereas they showed a decrease and then an increment in Hubbard birds with increasing of age (P < 0.01). Hubbard birds had the highest percentage of explorative pecking (7.65%), whereas Sasso birds had the lowest percentage of explorative pecking (4.33% at day 63, P < 0.01). The duration of tonic immobility was found to be longer, as well as the number of tonic immobility inductions was higher in Sasso birds compared to the Hubbard (26.49 vs. 19.68 s; 1.54 and 1.24, respectively P < 0.01). These findings indicate that birds of the Hubbard genotype may be more prone to aggression behaviors such as comb pecking and skin injuries, but they showed less fearful and higher walking ability, compared to Sasso birds.
GPR176 enhances the epithelial-mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway
Authors: Mu Guangchuan , Li Kaiyan , Hu Chaozhen , Cai Jintao , Ruan Huichao , Zhu Guanyu , Liu Dang 
Published: February 2025

Abstract

Gastric cancer is characterized by a high incidence and unfavorable prognosis. The exploration of novel molecular markers and a deeper understanding of their mechanisms of action hold the potential to offer fresh insights into gastric cancer treatment. Leveraging the TCGA-STAD and GSE66254 datasets, this study conducted an analysis on the relationship between GPR176 and clinical pathological features. Furthermore, it was validated in patients from The First Affiliated Hospital of Guangxi Medical University. Cell migration and invasion capabilities were evaluated through Transwell and scratch assays. Western blot was performed to detect the impact of GPR176 on PI3K/AKT/mTOR signaling pathway. Nude mouse tumorigenesis experiments were conducted to validate the impact of GPR176 on tumor growth in vivo. GPR176 exhibited higher expression levels in gastric cancer tissues, and was associated with a poor prognosis in patients with gastric cancer. Significant downregulation of GPR176 suppressed the invasive and migratory capabilities of gastric cancer cells, concomitant with the inhibition of the PI3K and EMT signaling pathways. However, the phenotypic changes induced by GPR176 downregulation and its inhibitory effects could be reversed by the overexpression of PIP5K1A. Nude mouse tumorigenesis experiments validated the findings from cell experiments, demonstrating that GPR176 downregulation suppressed tumor growth, while GPR176 overexpression promoted tumor growth. Similarly, after GPR176 downregulation, the EMT and PI3K/AKT/mTOR signaling pathways in tumor cells were significantly inhibited, whereas GPR176 upregulation led to their substantial activation. In conclusion, GPR176 emerged as a newly identified prognostic marker in this study. GPR176 may promote the EMT of gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway.
The Effect of Climate Change on the Sustainable Development of Algeria and its Regions for the period 2010 to 2022
Authors: Touitou Mohammed , Afandi waleed 
Published: February 2025

Abstract

The purpose of this research is to analyze the effect of climate change on sustainable development in Algeria and its regions during the period 2010–2022. To achieve this, an econometric analysis was conducted using generalized linear models, with Eviews 10.0 software to estimate a set of four econometric models. These models were designed to identify the causal relationships between climate change and sustainable development variables. The key findings of the research provide strong evidence that climate change negatively impacted sustainable development in Algeria and its regions, with a medium-intensity effect. Specifically, the study reveals that climate change had adverse effects on the economic, social, and environmental dimensions of sustainable development between 2010 and 2022.
Significant Muscle Strength Deficits Persist One Year After ACL Reconstruction with Hamstring Tendon Autografts
Authors: eğerci ömer faruk , köse özkan , arslan gufat , doğruöz fırat , yapar aliekber , dikmen ismail , ünal melih 
Published: February 2025

Abstract

Background
Hamstring tendon (HT) autografts are frequently used in anterior cruciate ligament (ACL) reconstruction, but their impact on muscle strength recovery and knee functionality remains a concern.
Purpose
This study aimed to evaluate the changes in muscle strength and recovery dynamics in patients undergoing anterior cruciate ligament (ACL) reconstruction using hamstring tendon autografts. The primary focus was on assessing quadriceps and hamstring strength, hamstring-to-quadriceps (H/Q) ratios, and Limb Symmetry Index (LSI) before and one year post-surgery. Additionally, the study examined clinical outcomes using the International Knee Documentation Committee (IKDC) and Lysholm Knee Scores.
Study Design:
Prospective cohort study; Level of evidence; 2.
Methods
Seventeen male patients (mean age 25.1 ± 7.1 years) who underwent ACL reconstruction with hamstring autografts were included. Isokinetic testing assessed muscle strength preoperatively and at 12 months postoperatively. Outcome measures included concentric and eccentric peak torque values for quadriceps and hamstrings, H/Q ratios, LSI, and functional outcomes measured by the International Knee Documentation Committee (IKDC) Score and the Lysholm Knee Score. Statistical analysis compared preoperative and postoperative data.
Results
Significant preoperative disparities were observed in concentric quadriceps strength between injured and uninjured sides, with persistent deficits postoperatively. Eccentric quadriceps strength showed stability, but hamstring strength significantly decreased post-surgery. Conventional and functional H/Q ratios worsened postoperatively, failing to meet normal benchmarks. LSI for both quadriceps and hamstrings remained below the 90% threshold postoperatively, indicating persistent strength deficits. Despite these muscle imbalances, significant improvements were observed in knee function, with increased IKDC and Lysholm scores.
Conclusion
One year after ACL reconstruction with hamstring tendon autografts, patients exhibit substantial deficits in quadriceps and hamstring strength, reflected in lowered H/Q ratios and LSI values. Despite these deficits, significant improvements in knee function and stability are observed. Extended and targeted rehabilitation focusing on concentric and eccentric muscle strengthening may be necessary for optimal recovery.
Suspended graphene-based NEMS accelerometers with direct electrical readout
Authors: Fan Xuge , Ding Jie , He Chang , Ma Hongliang , Zhang Wendong 
Published: February 2025

Abstract

Atomically thin suspended graphene can be used as NEMS transducers for ultra-small and high-performance sensors due to its excellent mechanical and electrical properties. Most applications of suspended graphene in NEMS devices are limited to pressure sensors, resonators, switches, etc. Graphene-based NEMS accelerometers have rarely been reported, with limitations such as mechanical robustness, life span and device yield, thereby limiting their practical applications. Here, we reported piezoresistive graphene-based NEMS accelerometers with high manufacturing yield, excellent mechanical robustness and stability, and long life span, in which the width of trenches for suspending graphene membranes was only 1 µm and fully-clamped suspended double-layer graphene membranes with an attached SiO2/Si proof mass was used as acceleration transducer. The impact of geometrical sizes of the proof mass attached to the suspended graphene membranes on the output signal of devices has been studied. These findings would contribute to rapid developments and practical applications of ultra-small and high-performance graphene-based NEMS accelerometers and related devices.
Evaluation of pyroptosis-associated genes in endometrial cancer based on the 101- combination machine learning framework and multi-omics data
Authors: Huang Li Juan , Chen Lin , Tang Min , Zhan Shi Tong , Chen Feng , Teng An Yi , Sang Wei Lin , Zhou Li Na , Yang Ye 
Published: February 2025

Abstract

Background
Endometrial cancer (EC) represents a common malignancy within gynecological cancers, characterized by a notably high mortality rate. The absence of reliable prognostic biomarkers significantly impairs the effectiveness of predictive, preventive, and personalized medicine (PPPM/3PM) strategies. Pyroptosis, a distinct form of programmed cell death, has been closely linked to anti-cancer immune responses. Nonetheless, the precise role of pyroptosis in the context of EC remains elusive.
Methods
Pyroptosis-associated genes (PAGs) were screened in Msigdb. We used consensus clustering to classify PAGs from TCGA-UCEC into two clusters, and examined their characteristics. The Seurat package was employed to analyze significant PAGs in EC single-cell data. The mime package was utilized to screen suitable machine learning approaches and build models. A nomogram was constructed to validate the model's performance. Additionally, CIBERSORT was used to evaluate immune infiltration results, and TIDE scores from the TCIA database were applied to assess EC patients' responses to immune checkpoint therapy. Subsequently, we performed PAG-related pathway analysis in EC patients with or without response to PD-1 therapy using the CellChat module in Seurat. Finally, the OncoPredict package was used to predict drug sensitivity in EC patients.
Results
A consensus PAGs ("CASP3", "CHMP3", "CYCS", "GSDMD", "IRF1", and "NOD1") was constructed based on a 101-combination machine learning computational framework, demonstrating outstanding performance in predicting prognosis and clinical translation. We observed distinct biological functions and immune cell infiltration in the tumor microenvironment between the high- and low-risk groups. Notably, the immunophenoscore (IPS) score showed a significant difference between risk subgroups, suggesting a negative response to PD-1 in the high-risk group. Potential drugs targeting specific risk subgroups were also identified.
Conclusion
Our study constructed an PAGs that can serve as a promising tool for prognosis prediction, targeted prevention, and personalized medicine in EC.
From Night Lights to Wildfire Risk: Uncovering Human Exposure in a Mediterranean Hotspot
Authors: Turco Marco , Torres-Vázquez Miguel Ángel , Vaglie Matteo Dalle , Kettridge Nicholas , Miguez-Macho Gonzalo , Provenzale Antonello , Royé Dominic , Randelli Filippo , Martellozzo Federico 
Published: February 2025

Abstract

This study examines the evolution of human exposure to wildfires in Catalonia, Spain, over the period 1992–2021, by integrating geospatial data on fire perimeters, population, satellite-derived nighttime light (NTL) imagery, and settlement records. Although the burned area shows a slight statistically non-significant decrease (-0.43 km²/year), human exposure per unit of burned area has risen by 42% to 138%, depending on the buffer distance and dataset used. This alarming trend is mainly driven by rapid urban expansion and population redistribution, particularly in coastal regions, which highlights a growing intersection between human settlements and fire-prone areas. Our findings emphasize the critical role of urbanization in amplifying wildfire risks, underscoring the urgent need to integrate demographic dynamics into fire risk management strategies. By employing innovative proxies such as nighttime light data alongside high-resolution population and building density datasets, this study provides a comprehensive framework to assess wildfire exposure in rapidly urbanizing Mediterranean environments.