bluuebunny/crossref_metadata_2025_split huggingface dataset:
The reception process of a socio-educational detention center for adolescents from the perspective of environmental psychology
Authors: Pacheco Maria Eniana Araújo Gomes , Ferreira Karla Patrícia Martins , Baquit José Airton Nascimento Diógenes 
Published: April 2020

Introduction: The reception process aims to provide technical, psychosocial and medical care during the arrival of the adolescent in a juvenile detention after sentencing. This service is guided by the National System of Socio-Educational Care and follow a policy integrated with joint actions of accountability, education, health and social assistance, in the context of human development of socio-educational measures.
Objective: To describe the environmental traces left by adolescents after have completed the reception process in Socio-Educational detention Centers in the State of Ceará.
Methods: This is a cross sectional study, with descriptive and qualitative approach. The research was held in the areas where previously the adolescents had completed the reception process. Data were collected by systematic observation using field diary reports and discussions guided by content analysis.
Results: The environmental traces were associated with the adolescents' previous and current experiences, through the appropriation practices of the spaces of the Socio-educational Center, configured as a place of permanence, movement or passage in constant articulation with social, cultural, economic, political, historical and psychological factors.
Conclusion: In the State of Ceara, the areas of Detention Centers reserved for socio-educational purposes as a long-term space for psychosocial and medical care, violates the basic rights of comprehensive care for adolescents. This reality points to the vulnerability of adolescents when exposed to unhealthy physical structures, and demonstrates the need for studies that deepen the discussions from the perspective of the person-environment inter-relationship.
Validation of a food consumer frequency questionnaire for pregnant women in primary Health Care Units
Authors: Duarte Ana Carolina Oliveira Rodrigues , Pinho Lucinéia de , Silveira Marise Fagundes , Botelho Ernani Mendes 
Published: April 2020

Introduction: The Food Consumption Frequency Questionnaire (FCFQ) is a tool for assessing food consumption. However, to be used in pregnant women, it must be submitted to validation. The food consumption of pregnant women can impact on maternal and child health, becoming a public health issue. The questionnaire applied during pregnancy can create parameters for better prenatal care.
Objective: To validate a FCFQ for pregnant women attended at primary health care units.
Methods: The Food Consumption Frequency Questionnaire and two 24-hour recall were applied to 155 pregnant women from the municipality of Montes Claros, Minas Gerais, Brazil. The questionnaire results were contrasted with the average of the two 24- hour recall using the chi-square test. The mean of the differences were estimated by limits of agreement. Pearson's correlation test and Intraclass Correlation Coefficient as well were used. Food consumption medians and quartiles were calculated.
Results: The value of estimate energy consumption and most nutrients was higher by the questionnaire. The concordance between the methods in the classification in quartiles of consumption was variable, being similar for 26.11% and opposite for 12.1%. After adjusting for energy, the correlation coefficient ranged from -0.144 (carbohydrate) to 0.337 (potassium). The questionnaire estimated values were approximately 1.94 higher than the 24 hour recall, corresponding to 20% higher for almost all nutrients.
Conclusion: The FCFQ showed to be a good instrument to be considered clinically as well as for research purposes in Brazilian pregnant women, this tool measures appropriately food intake which is fundamental for establishing health conditions during pregnancy, helping to assess the association between diet, nutrition and health..
Brazilian girls who practice classical ballet develop different motor strategies regarding postural stability
Authors: Santos Rafaela Noleto dos , Bittar Adriano Jabur , Hamu Tânia Cristina Dias da Silva , Picon Andreja Paley , Formiga Cibelle Kayenne Martins Roberto 
Published: April 2020

Introduction: The growth and development of children is a product of the interaction of biological andenvironmental factors. Dance practice can optimize various aspects of motor control, coordination andbalance in childhood and adolescence.
Objective: The objective of the present study was to verify how the practice of classical ballet, at a professional level, can influence the plantar pressures and balance of children and adolescents, as well as to verify if subjects’ vision and posture of the upper limbs can interfere in this result.
Methods: Cross-sectional study performed with 111 girls aged 10 to 15 years who practice classical ballet (n = 56) and non-dancers (n = 55). Anthropometry (BMI), plantar pressures and postural stability (baropodometry platform) were assessed. Three different conditions: eyes open (EO), eyes closed (EC) and arms outstretched (AO) were observed. Data analysis performed by using group comparison and correlation tests.
Results: Those who practiced classical ballet placed less weight onto the left forefoot, presented lower values of maximum pressure and plantar surface area in all the evaluated conditions and moved less in the stabilometry analysis. It also observed that ballet dancers were more influenced by vision and positioning of the upper limbs than the group of non-dancers. Length of time as a dancer influenced the results found.
Conclusions: Girls who practice classical ballet have specific characteristics of plantar pressure and develop different postural control strategies when compared to typical girls of similar age, especially in the arms outstretch position.
Infants’ peer interaction in institutional foster care service
Authors: Moura Gabriella Garcia , Souza Gisele Mathias de , Amorim Kátia de Souza 
Published: April 2020

Introduction: Based on the perspective of children’s intersubjectivity, it is understood that infants are able to interact with infants from a very early age. These interactions can offer important constitutive experiences for them.
Objective: It was investigated how interactions between infants-infants/toddlers in institutional care occur, describing: the frequency of these interactions; the emotional-communicative resources involved; partners’ responsiveness; and the environmental organization.
Methods: A qualitative, descriptive, and exploratory case study was conducted. Participants were focal baby (aged between 10 and 13 months) and their interactive peers (4 to 17 months) in institutional care. We used weekly video recordings for three months in the naturalistic context. The categories “attention orientation”, “search/maintenance of proximity”, “social exchanges”, and “responsiveness” were quantified and compared with the interaction between infant and caregiver. Interactive episodes were also thoroughly described.
Results: Cribs, strollers, gates, and grids, with few toys available, marked the organization of the physical-social space. It was observed that the infants spent most of their time in individual activities (alone); and their social behaviors were more often directed to caregivers.
The interactions between infants/toddlers were less frequent, although it was with the peers that social exchanges, joint activities, and co-regulated interactions occurred the most (with reciprocity and sharing). Peer responsiveness also involved empathic and pro-social behaviors (with experiences of interpersonal engagement), where attentional, emotional, and motivational processes operated.
Conclusion: Peers interactions between infants/toddlers in institutional care were infrequent. However, when it occurred, the children showed sensitivity and responsiveness to their peers' emotional-communicative expressions. The organization of the institutional environment proved to be a relevant constraint of peer interactions: due to the material/spatial arrangement that made contact between children difficult; and by the absence of the adult as a promoter of these interactions. Finally, we call attention to the need for further investigations about interactive indicators of infants in institutional care.
Disparate expression specificities coded by a shared Hox-C enhancer
Authors: Miller Steve W , Posakony James W 
Published: April 2020

Can a single regulatory sequence be shared by two genes undergoing functional divergence? Here we describe a single promiscuous enhancer within the Drosophila Antennapedia Complex, EO053, that directs aspects of the expression of two adjacent genes, pb (a Hox2 ortholog) and zen2 (a divergent Hox3 paralog), with disparate spatial and temporal expression patterns. We were unable to separate the pb-like and zen2-like specificities within EO053, and we identify sequences affecting both expression patterns. Importantly, genomic deletion experiments demonstrate that EO053 cooperates with additional pb- and zen2-specific enhancers to regulate the mRNA expression of both genes. We examine sequence conservation of EO053 within the Schizophora, and show that patterns of synteny between the Hox2 and Hox3 orthologs in Arthropods are consistent with a shared regulatory relationship extending prior to the Hox3/zen divergence. Thus, EO053 represents an example of two genes having evolved disparate outputs while utilizing this shared regulatory region.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Tricyclics and malignant syndrome
Authors: Abbar M , Carlander B , Castelnau D 
Published: July 2002

SummaryA clinical and biological pattern similar to that of neuroleptic malignant syndrome is reported in a depressed patient treated with trimipramine, without any concomitant use of neuroleptics. The antidopaminergic properties of this drug, one of the tricyclic antidepressants, may account for this uncommon side effect.
Intraperitoneal cisplatin‐based chemotherapy vs. intravenous cisplatin‐based chemotherapy for stage III optimally cytoreduced epithelial ovarian cancer
Authors: Yen M.‐S. , Juang C.‐M. , Lai C.‐R. , Chao G.‐C. , Ng H.‐T. , Yuan C.‐C. 
Published: July 2002

AbstractObjective: To compare the survival between intraperitoneal cisplatin‐based chemotherapy (IPCT) and intravenous cisplatin‐based chemotherapy (IVCT) in stage III epithelial ovarian cancer with minimal residual disease (<1 cm) after primary debulking surgery. Method: One hundred and thirty‐two patients with stage III epithelial ovarian cancer after optimal primary debulking surgery with minimal residual disease between April 1990 and March 1995 were entered into a randomized clinical trial in which IPCT or IVCT was administered at 3‐week intervals. Patients in the IPCT arm received cisplatin‐based (100 mg/m2) intraperitoneal chemotherapy. Patients in the IVCT arm received cisplatin‐based (50 mg/m2) intravenous chemotherapy. The tumor response was assessed every 3 months. The hematological toxicity using the South West Oncology Group (SWOG) toxicity criteria was assessed. Catheter complications associated with intraperitoneal chemotherapy were also analyzed. Result: The estimated median survival in the IPCT group was 43 months (95% confidence interval, 34–54) and IVCT group was 48 months (95% confidence interval, 37–59). The hazard ratio of death was not statistically significant between IPCT and IVCT (hazard ratio, 1.13; 95% CI, 0.69–1.86; P=0.317). The frequencies of hematological toxic effects were significantly lower in the IPCT group than in the IVCT group. Conclusion: Intravenous and intraperitoneal chemotherapy are associated with equivalent survival in patients with minimal residual stage III epithelial ovarian cancer after optimal cytoreductive surgery.
The scientific theory‐building process: a primer using the case of TQM
Authors: Handfield Robert B , Melnyk Steven A 
Published: July 2002

AbstractAs Operations Management (OM) researchers begin to undertake and publish more empirical research, there is a need to understand the nature of the scientific theory‐building process implicit in this activity. This tutorial presents a process map approach to this process. We begin by defining the nature of scientific knowledge, and proceed through the stages of the theory‐building process, using illustrations from OM research in Total Quality Management. The tutorial ends with a discussion of the criteria for OM journal reviewers to consider in evaluating theory‐driven empirical research, and suggests a number of OM topic areas that require greater theory development.
A role for an AP‐1‐like site in the expression of the myelin basic protein gene during differentiation
Authors: Miskimins Robin , Miskimins W.Keith 
Published: July 2002

AbstractDifferentiation of oligodendrocyte progenitors into mature oligodendrocytes involves the timely, cell‐type specific expression of a number of different genes. Among these, the expression of the myelin basic protein (MBP) gene closely parallels the course of oligodendrocyte differentiation. To understand how transcription of the myelin basic protein gene is controlled, binding to the distal end of the 5′ flanking sequence of the MBP gene was investigated. Specific protein‐DNA complexes were localized to an AP‐1‐like element located between −1230 and −1240. The protein–DNA complexes formed at this site were shown to change as the cells differentiated. In undifferentiated cells two complexes were formed but, as the cells differentiated, binding was nearly completely lost. One of the two complexes was shown to contain a member of the fos family of transcription factors but no jun family members were involved. Mutation of the AP‐1‐like site resulted in loss of the complex and a change in expression of a reporter construct driven by the mutated promoter sequence. These results demonstrate a role for the AP‐1‐like site in repression of MBP gene expression in oligodendrocyte progenitor cells.
Adjunctive gabapentin treatment of bipolar disorder
Authors: Vieta E , Martinez-Arán A , Nieto E , Colom F , Reinares M , Benabarre A , Gastó C 
Published: July 2002

IntroductionThe aim of this study was to analyze the effectiveness of gabapentin administration to bipolar patients who had an incomplete response to other mood stabilizers.Subjects and methodsTwenty-two RDC bipolar 1 and II patients were assessed by means of the SADS and entered if they gave their consent to participate. All them had suffered from frequent relapses, subsyndromal features (mostly depressive) and incomplete response to other drugs. They all received open-label increasing doses of gabapentin until clinical response. The patients were assessed through the CGI-BP and a specific questionnaire at baseline and at 12 weeks of follow-up.ResultsSix out of the 22 patients dropped out for various reasons (four because of relapse, one because of side effects and one more because of poor compliance). Eight of the 16 patients that completed the 12-week follow-up showed at least two stages of improvement in the CGI. Using the last observation-carried forward analysis, the improvement was statistically significant for the depression subscale, and apparently related to social functioning, irritability and anxiety. Only one patient dropped out because of intolerance (mild rash). The mean dose of gabapentin was 1,310 mg/day.ConclusionGabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. These results should be confirmed in randomized clinical trials.
Psychotic versus nonpsychotic bipolar outpatient depression
Authors: Benazzi F. 
Published: July 2002

SummaryPsychotic bipolar depression was compared with nonpsychotic bipolar depression. Psychotic (n = 59) and nonpsychotic (n = 176) bipolar depressed outpatients were SCID-DSM-IV interviewed. Psychotic bipolar depression had significantly higher severity, more chronicity, fewer atypical features and axis I co-morbidity, more bipolar I, and fewer bipolar II patients. Age at onset, duration of illness, gender, and recurrences, were not significantly different.
Global FKRP Registry: observations in more than 300 patients with Limb Girdle Muscular Dystrophy R9
Authors: Murphy Lindsay B. , Schreiber‐Katz Olivia , Rafferty Karen , Robertson Agata , Topf Ana , Willis Tracey A. , Heidemann Marcel , Thiele Simone , Bindoff Laurence , Laurent Jean‐Pierre , Lochmüller Hanns , Mathews Katherine , Mitchell Claudia , Stevenson John Herbert , Vissing John , Woods Lacey , Walter Maggie C. , Straub Volker 
Published: April 2020

AbstractObjectiveThe Global FKRP Registry is a database for individuals with conditions caused by mutations in the Fukutin‐Related Protein (FKRP) gene: limb girdle muscular dystrophy R9 (LGMDR9, formerly LGMD2I) and congenital muscular dystrophies MDC1C, Muscle–Eye–Brain Disease and Walker–Warburg Syndrome. The registry seeks to further understand the natural history and prevalence of FKRP‐related conditions; aid the rapid identification of eligible patients for clinical studies; and provide a source of information to clinical and academic communities.MethodsRegistration is patient‐initiated through a secure online portal. Data, reported by both patients and their clinicians, include: age of onset, presenting symptoms, family history, motor function and muscle strength, respiratory and cardiac function, medication, quality of life and pain.ResultsOf 663 registered participants, 305 were genetically confirmed LGMDR9 patients from 23 countries. A majority of LGMDR9 patients carried the common mutation c.826C > A on one or both alleles; 67.9% were homozygous and 28.5% were compound heterozygous for this mutation. The mean ages of symptom onset and disease diagnosis were higher in individuals homozygous for c.826C > A compared with individuals heterozygous for c.826C > A. This divergence was replicated in ages of loss of running ability, wheelchair‐dependence and ventilation assistance; consistent with the milder phenotype associated with individuals homozygous for c.826C > A. In LGMDR9 patients, 75.1% were currently ambulant and 24.6%, nonambulant (unreported in 0.3%). Cardiac impairment was reported in 23.2% (30/129).InterpretationThe Global FKRP Registry enables the collection of patient natural history data, which informs academics, healthcare professionals and industry. It represents a trial‐ready cohort of individuals and is centrally placed to facilitate recruitment to clinical studies.
Trypsin‐Instructed Self‐Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells
Authors: Kim Beom Jin , Fang Yu , He Hongjian , Xu Bing 
Published: April 2020

AbstractSelectively targeting the endoplasmic reticulum (ER) of cancer cells, though promising a new strategy for cancer therapy, remains underdeveloped. Enzyme‐instructed self‐assembly (EISA) is emerging as a promising approach for selectively targeting ER of cancer cells. This work reports an easily accessible branched peptide that consists of a D‐tetrapeptide backbone and a branch with the sequence of KYDKKKKDG (K: lysine; Y: tyrosine; D: aspratic acid; G: glycine), being an EISA substrate of typsin‐1 (PRSS1), selectively inhibits cancer cells. Depending on the type of cells, the level of PRSS1 expression dictates the cytotoxicity of the branched peptide. Moreover, immunostaining and fluorescent imaging reveal that PRSS1 overexpresses on the ER of a high‐grade serous ovarian cancer cell line (OVSAHO). The overexpression of PRSS1 renders the branched peptide to exhibit high selectivity against OVSAHO by the in situ formation of the peptide assemblies on the ER of OVSAHO cells, which causes ER stress and eventual cell death. This work, illustrating trypsin‐guided EISA for inhibiting cancer cells by enzymatic reaction on ER for the first time, offers a new way to target the subcellular organelles of cancer cells for potential cancer therapy.
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
Authors: Vassey Matthew J. , Figueredo Grazziela P. , Scurr David J. , Vasilevich Aliaksei S. , Vermeulen Steven , Carlier Aurélie , Luckett Jeni , Beijer Nick R. M. , Williams Paul , Winkler David A. , de Boer Jan , Ghaemmaghami Amir M. , Alexander Morgan R. 
Published: April 2020

AbstractMacrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of “immune‐instructive” topographies to modulate macrophage function and thus foreign body responses to biomaterials. However, no generalizable understanding of the inter‐relationship between topography and cell response exists. A high throughput screening approach is therefore utilized to investigate the relationship between topography and human monocyte–derived macrophage attachment and phenotype, using a diverse library of 2176 micropatterns generated by an algorithm. This reveals that micropillars 5–10 µm in diameter play a dominant role in driving macrophage attachment compared to the many other topographies screened, an observation that aligns with studies of the interaction of macrophages with particles. Combining the pillar size with the micropillar density is found to be key in modulation of cell phenotype from pro to anti‐inflammatory states. Machine learning is used to successfully build a model that correlates cell attachment and phenotype with a selection of descriptors, illustrating that materials can potentially be designed to modulate inflammatory responses for future applications in the fight against foreign body rejection of medical devices.
Robust Atomistic Modeling of Materials, Organometallic, and Biochemical Systems
Authors: Spicher Sebastian , Grimme Stefan 
Published: April 2020

AbstractModern chemistry seems to be unlimited in molecular size and elemental composition. Metal‐organic frameworks or biological macromolecules involve complex architectures and a large variety of elements. Yet, a general and broadly applicable theoretical method to describe the structures and interactions of molecules beyond the 1000‐atom size regime semi‐quantitatively is not self‐evident. For this purpose, a generic force field named GFN‐FF is presented, which is completely newly developed to enable fast structure optimizations and molecular‐dynamics simulations for basically any chemical structure consisting of elements up to radon. The freely available computer program requires only starting coordinates and elemental composition as input from which, fully automatically, all potential‐energy terms are constructed. GFN‐FF outperforms other force fields in terms of generality and accuracy, approaching the performance of much more elaborate quantum‐mechanical methods in many cases.