bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial performance of shipping firms that increase LNG carriers and the support of eco-innovation
Authors: Lim Kian-Guan , Lim Michelle 
Published: November 2020

AbstractThe technology to liquefy natural gas for transport to countries worldwide and the increasing use of natural gas as a cleaner fossil fuel for industry and household meant that the supply of liquified natural gas (LNG) worldwide is a profitable trend. Shipping companies can strategically choose to diversify into LNG fleet to grasp this trend. By supplying more LNG shipping capacities, the greater availability of LNG worldwide, as a source of marine fuel and as a source of cleaner energy in replacing coal and oil, is supporting eco-innovation. In this paper, we investigate three economic and financial benefits to a shipping firm that diversified into liquefied natural gas (LNG) shipping, namely firm profitability performance, firm efficiency, and stock return performance. We also investigate if there is an early mover advantage in doing so. Our empirical findings indicate that fleet diversification into LNG carriers resulted in higher profitability and better operational efficiency. For the listed shipping firms, their stock returns increased with diversified exposures to the LNG business. There is some evidence of higher profitability in the early mover advantage. Firms that originated in LNG business also benefited when there was diversification into the non-LNG business.
Benefits of immersive collaborative learning in CAVE-based virtual reality
Authors: de Back Tycho T. , Tinga Angelica M. , Nguyen Phong , Louwerse Max M. 
Published: November 2020

AbstractHow to make the learning of complex subjects engaging, motivating, and effective? The use of immersive virtual reality offers exciting, yet largely unexplored solutions to this problem. Taking neuroanatomy as an example of a visually and spatially complex subject, the present study investigated whether academic learning using a state-of-the-art Cave Automatic Virtual Environment (CAVE) yielded higher learning gains compared to conventional textbooks. The present study leveraged a combination of CAVE benefits including collaborative learning, rich spatial information, embodied interaction and gamification. Results indicated significantly higher learning gains after collaborative learning in the CAVE with large effect sizes compared to a textbook condition. Furthermore, low spatial ability learners benefitted most from the strong spatial cues provided by immersive virtual reality, effectively raising their performance to that of high spatial ability learners. The present study serves as a concrete example of the effective design and implementation of virtual reality in CAVE settings, demonstrating learning gains and thus opening opportunities to more pervasive use of immersive technologies for education. In addition, the study illustrates how immersive learning may provide novel scaffolds to increase performance in those who need it most.
Ecological momentary assessment versus retrospective assessment for measuring change in health-related quality of life following cardiac intervention
Authors: Oreel Tom H. , Delespaul Philippe , Hartog Iris D. , Henriques José P. S. , Netjes Justine E. , Vonk Alexander B. A. , Lemkes Jorrit , Scherer-Rath Michael , van Laarhoven Hanneke W. M. , Sprangers Mirjam A. G. , Nieuwkerk Pythia T. 
Published: November 2020

Abstract
Background
Measuring change in health-related quality-of-life (HRQoL) is important to assess the impact of disease and/or treatment. Ecological momentary assessment (EMA) comprises the repeated assessment of momentary HRQoL in the natural environment and is particularly suited to capture daily experiences. Our objective was to study whether change in momentary measures or retrospective measures of HRQoL are more strongly associated with criterion measures of change in HRQoL.
Twenty-six coronary artery disease patients completed momentary and retrospective HRQoL questionnaires before and after coronary revascularization. Momentary HRQoL was assessed with 14 items which were repeatedly presented 9 times a day for 7 consecutive days. Each momentary assessment period was followed by a retrospective HRQoL questionnaire that used the same items, albeit phrased in the past tense and employing a one-week time frame. Criterion measures of change comprised the New York Heart Association functioning classification system and the Subjective Significance Change Questionnaire. Regression analysis was used to determine the association of momentary and retrospective HRQoL change with the criterion measures of change.

Results
Change according to momentary HRQoL items was more strongly associated with criterion measures of change than change according to retrospective HRQoL items. Five of 14 momentary items were significantly associated with the criterion measures. One association was found for the retrospective items, however, in the unexpected direction.

Conclusion
Momentary HRQoL measures better captured change in HRQoL after cardiac intervention than retrospective HRQoL measures. EMA is a valuable expansion of the armamentarium of psychometrically sound HRQoL measures.
Exploring the multiple roles of guardian of the genome: P53
Authors: Feroz Wasim , Sheikh Arwah Mohammad Ali 
Published: November 2020

AbstractBackgroundCells have evolved balanced mechanisms to protect themselves by initiating a specific response to a variety of stress. TheTP53gene, encoding P53 protein, is one of the many widely studied genes in human cells owing to its multifaceted functions and complex dynamics. The tumour-suppressing activity of P53 plays a principal role in the cellular response to stress. The majority of the human cancer cells exhibit the inactivation of the P53 pathway. In this review, we discuss the recent advancements in P53 research with particular focus on the role of P53 in DNA damage responses, apoptosis, autophagy, and cellular metabolism. We also discussed important P53-reactivation strategies that can play a crucial role in cancer therapy and the role of P53 in various diseases.Main bodyWe used electronic databases like PubMed and Google Scholar for literature search. In response to a variety of cellular stress such as genotoxic stress, ischemic stress, oncogenic expression, P53 acts as a sensor, and suppresses tumour development by promoting cell death or permanent inhibition of cell proliferation. It controls several genes that play a role in the arrest of the cell cycle, cellular senescence, DNA repair system, and apoptosis. P53 plays a crucial role in supporting DNA repair by arresting the cell cycle to purchase time for the repair system to restore genome stability. Apoptosis is essential for maintaining tissue homeostasis and tumour suppression. P53 can induce apoptosis in a genetically unstable cell by interacting with many pro-apoptotic and anti-apoptotic factors.Furthermore, P53 can activate autophagy, which also plays a role in tumour suppression. P53 also regulates many metabolic pathways of glucose, lipid, and amino acid metabolism. Thus under mild metabolic stress, P53 contributes to the cell’s ability to adapt to and survive the stress.ConclusionThese multiple levels of regulation enable P53 to perform diversified roles in many cell responses. Understanding the complete function of P53 is still a work in progress because of the inherent complexity involved in between P53 and its target proteins. Further research is required to unravel the mystery of this Guardian of the genome “TP53”.
Congenital giant Bednar tumor in a child: surgical challenges in a young infant: a case report
Authors: Gunasekaran Vidhya , Peters Nitin J. , Samujh Ram 
Published: November 2020

Abstract
Background
Bednar tumor is a pigmented variant of the uncommon dermatofibrosarcoma protuberans (DFSP). It is a disease of the middle aged and elderly and has been rarely described in the pediatric population.

Case presentation
We report a rare case of a giant Bednar tumor present since birth, in a 2-year-old male child. It was present over the lower back and managed by surgical excision.

Conclusions
Bednar tumor is a rarity in children and is managed with aggressive wide local excision with margin of at least 1 cm. A close clinical follow-up is mandatory.
Obscene Textures: The Erotics of Disgust in the Writings of Ismat Chughtai
Authors: Khanna Neetu 
Published: November 2020

Abstract
This article revisits the Marxist anticolonial feminist writings of Urdu author Ismat Chughtai through a materialist exploration into how the female body—with its erotic curvatures and grotesque protuberances, its sticky and viscous textures and fluids—becomes the focalized object of what the author terms the erotics of disgust. Chughtai is perhaps most famous for her being tried for obscenity in 1942 for her most famous short story, “The Quilt” (“Lihaaf”), which narrates a young girl’s encounter with the erotic relationship of a middle-class Muslim woman and her female servant. As Chughtai herself recounts, however, she was acquitted because the prosecution could never point to the exact words that were to be considered obscene. The author argues that we read Chughtai’s extraordinary inquiries into the imbrication of desire and disgust as the visceral sites of gender discipline, as the question of the “modern” Muslim female citizen subject hangs in the balance of an emergent Indian nationhood. The author offers a queer feminist critique of the traditional phenomenology of disgust by analyzing the codes of erotic texture produced out of histories of colonial hygiene and bourgeois sexual discipline in late colonial India.
From Hampstead to Buenos Aires and Beyond: Anticipating Worlds in Julio Cortázar’s Imagen de John Keats
Authors: Moy Olivia Loksing 
Published: November 2020

Abstract
In the 1950s, the Argentinian author Julio Cortázar (1914–84) composed Imagen de John Keats, a little-known work that merges his own life with that of the British Romantics. Part biography and part autobiography, it includes personal essays and literary criticism that weave through the poems, life, and letters of Keats from his early youth to death. This article positions Imagen de John Keats as an important case study in world literature criticism. It demonstrates how Cortázar was not only a Latin American Boom writer who enjoyed international fame but also an idiosyncratic practitioner of reading and writing methods that transcend nation and period. Modeling innovative techniques that the author calls “automatic translation” and “global close reading,” Cortázar anticipates some of the problems recently voiced in critical debates surrounding world literature. Imagen de John Keats is simultaneously an example of world literature that blends fiction and nonfiction, and a model for world literature criticism.
Gender Relations in Racialized Ghagar Communities of Egypt
Authors: Parrs Alexandra 
Published: November 2020

AbstractThis article reflects on gender relations among Egyptian Dom/Ghagar. It is based on an examination of the representations of Dom women by European Orientalists in Egyptian movies, Egyptian media, and ethnographic research among Dom communities in Egypt, particularly narratives describing marital practices: bride price, divorce, polygyny, and early marriage. The article confronts the discourse of Ghagar and non-Ghagar about the position of women within Ghagar communities. It hypothesizes that representations of gender specificities among Ghagar communities may be concomitantly anchored in real practices, in perceptions of difference among their practices by members of Ghagar communities, and in external discourse. Egyptian media tend to project an image of the Ghagar as a society in which women are more powerful than men—which has a negative connotation. The article asks if those perceptions and interactions have helped create a dimension of Ghagar identity.
Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium
Authors: Ishii Ryutaro , Yanagisawa Hiromi , Sada Aiko 
Published: November 2020

ABSTRACT
Adult tissues contain label-retaining cells (LRCs), which are relatively slow-cycling and considered to represent a property of tissue stem cells (SCs). In the ocular surface epithelium, LRCs are present in the limbus and conjunctival fornix; however, the character of these LRCs remains unclear, owing to lack of appropriate molecular markers. Using three CreER transgenic mouse lines, we demonstrate that the ocular surface epithelium accommodates spatially distinct populations with different cell division dynamics. In the limbus, long-lived Slc1a3CreER-labeled SCs either migrate centripetally toward the central cornea or slowly expand their clones laterally within the limbal region. In the central cornea, non-LRCs labeled with Dlx1CreER and K14CreER behave as short-lived progenitor cells. The conjunctival epithelium in the bulbar, fornix and palpebral compartment is regenerated by regionally unique SC populations. Severe damage to the cornea leads to the cancellation of SC compartments and conjunctivalization, whereas milder limbal injury induces a rapid increase of laterally expanding clones in the limbus. Taken together, our work defines compartmentalized multiple SC/progenitor populations of the mouse eye in homeostasis and their behavioral changes in response to injury.
Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease
Authors: Vien Thuy N. , Ng Leo C. T. , Smith Jessica M. , Dong Ke , Krappitz Matteus , Gainullin Vladimir G. , Fedeles Sorin , Harris Peter C. , Somlo Stefan , DeCaen Paul G. 
Published: November 2020

ABSTRACT
Approximately 15% of autosomal dominant polycystic kidney disease (ADPKD) is caused by variants in PKD2. PKD2 encodes polycystin-2, which forms an ion channel in primary cilia and endoplasmic reticulum (ER) membranes of renal collecting duct cells. Elevated internal Ca2+ modulates polycystin-2 voltage-dependent gating and subsequent desensitization – two biophysical regulatory mechanisms that control its function at physiological membrane potentials. Here, we refute the hypothesis that Ca2+ occupancy of the polycystin-2 intracellular EF hand is responsible for these forms of channel regulation, and, if disrupted, results in ADPKD. We identify and introduce mutations that attenuate Ca2+-EF hand affinity but find channel function is unaltered in the primary cilia and ER membranes. We generated two new mouse strains that harbor distinct mutations that abolish Ca2+-EF hand association but do not result in a PKD phenotype. Our findings suggest that additional Ca2+-binding sites within polycystin-2 or Ca2+-dependent modifiers are responsible for regulating channel activity.
Stage 2 Registered Report: How subtle linguistic cues prevent unethical behaviors
Authors: Guo Wen , Liu Huanxu , Yang Jingwen , Mo Yuqi , Zhong Can , Yamada Yuki 
Published: November 2020

Background: Differences in descriptions can influence people’s evaluations and behaviors. A previous study by Bryan and colleagues suggested that subtle linguistic differences in ethical reminders can differentially prevent readers’ unethical behavior. The present study tried to replicate the previous finding in the Japanese context (Experiment 1); additionally, we explored the influence of unfamiliar Japanese instruction words that captured participants’ attention (Experiment 2). Methods: In two online experiments, participants were asked to make 10 coin-tosses and report the number of “heads” results, which would indicate the amount of money that they could earn. In Experiment 1, we analyzed the difference in the number of “heads” results as reported by 768 participants under three conditions with different instructions (“Don’t cheat” vs. “Don’t be a cheater” vs. baseline as a control). In Experiment 2, we conducted an extended experiment with an additional task in which more attention was directed toward the text. Results: In Experiment 1, we successfully replicated the results of the original experiment. The results of Experiment 2 showed no evidence that the results in Experiment 1 were influenced by attentional factors. Conclusions: In conclusion, the results of the present study supported the hypothesis that self-identity-related words of moral reminder curb unethical behaviors more effectively. Stage 1 report: https://doi.org/10.12688/f1000research.20183.4
Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC
Authors: Garzón-Castaño Sandra Catalina , Jiménez-González Francisco Javier , Veloza Luz Angela , Sepúlveda-Arias Juan Carlos 
Published: November 2020

Background: A large number of chemical compounds exert their antioxidant effects by activation of key transcriptional regulatory mechanisms, such as the transcription factor Nrf2. The aim of this study was to evaluate the activation of the Keap1-Nrf2 pathway by both the n-butanol extract obtained from the inner bark of Tabebuia rosea (Bertol) DC and specioside isolated from this extract. Methods: The antioxidant activity of the extract and specioside isolated from the inner bark of T. rosea were evaluated using the oxygen radical absorbance capacity (ORAC) and the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) techniques, whereas their effects on the viability of HepG2 cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The effects of the compound and the extract on activating the Keap1-Nrf2 pathway were evaluated using a Nrf2 Transcription Factor Assay kit. Induction of the Nrf2-mediated antioxidant response genes HMOX-1 and NQO1 was evaluated by real-time PCR. The protective effects against H2O2-induced oxidative stress in HepG2 cells was determined as the percent protection using the MTT method. Results: Both the n-butanol extract and specioside exhibited activity at low concentrations without affecting cellular viability, since the cell viability was greater than 80% after 24 hours of exposure at each tested concentration. In addition, Nrf2 dissociated from Keap1 after treatment with the n-butanol extract at a concentration of 0.25 µg/mL after 4 hours of exposure. An increase in the Nrf2 level in the cytoplasm after 4 hours of exposure to 2 μM specioside was observed. Nrf2 levels stabilized in the nucleus 12 hours after stimulation with both specioside and the extract. After 6 hours of stimulation, both the extract and specioside induced the expression of HMOX-1 and NQO1. Conclusion: The n-butanol extract from the inner bark of T. rosea and specioside produced protective effects against H2O2-induced oxidative stress in HepG2 cells.
RETRACTED: Full-color micro-LED displays with cadmium-free quantum dots patterned by photolithography technology
Authors: Tian Wenya , Dou Long , Jin Zhong , Xiao Jinqing , Li Junhui 
Published: November 2020

A full-color display consisting of red and green photoluminescence
cadmium-free quantum dots (QDs) as the color conversion material and excited by a
68×68
blue micro-LED flip chip array
mounted on an active-matrix driving board was completed in this study. The QD photoresist (QDPR)
lithography technology was reported in detail, and it has been proven
to be a stable process route. The suitable thickness of
12±1µm
of the QDPR and black matrix was
proposed to reduce the light cross talk between different sub-pixels.
The thickness of the common color filter of 1–2 µm was made
successfully between the quantum dot film and the cover glass, which
can greatly reduce the leakage of blue backlight and decrease the
quantum dots excitation by the ambient light, as well as improve the
color gamut and color purity of the display panel. In addition, the
high red and green light conversion efficiency reaches up to 78.1% and
296.5%, respectively, and the screen display can reach 98.8% NTSC on
the CIE 1931 chromaticity. Representative RGB monochromatic pictures
were displayed successfully and
≤0.04
viewing angle deviation of the
display was measured precisely.
Point-of-care diagnostic tests for influenza in the emergency department: A cost-effectiveness analysis in a high-risk population from a Canadian perspective
Authors: Mac Stephen , O’Reilly Ryan , Adhikari Neill K. J. , Fowler Robert , Sander Beate 
Published: November 2020

Background
Our objective was to assess the cost-effectiveness of novel rapid diagnostic tests: rapid influenza diagnostic tests (RIDT), digital immunoassays (DIA), rapid nucleic acid amplification tests (NAAT), and other treatment algorithms for influenza in high-risk patients presenting to hospital with influenza-like illness (ILI).

Methods
We developed a decision-analytic model to assess the cost-effectiveness of diagnostic test strategies (RIDT, DIA, NAAT, clinical judgement, batch polymerase chain reaction) preceding treatment; no diagnostic testing and treating everyone; and not treating anyone. We modeled high-risk 65-year old patients from a health payer perspective and accrued outcomes over a patient’s lifetime. We reported health outcomes, quality-adjusted life years (QALYs), healthcare costs, and net health benefit (NHB) to measure cost-effectiveness per cohort of 100,000 patients.

Results
Treating everyone with no prior testing was the most cost-effective strategy, at a cost-effectiveness threshold of $50,000/QALY, in over 85% of simulations. This strategy yielded the highest NHB of 15.0344 QALYs, but inappropriately treats all patients without influenza. Of the novel rapid diagnostics, NAAT resulted in the highest NHB (15.0277 QALYs), and the least number of deaths (1,571 per 100,000). Sensitivity analyses determined that results were most impacted by the pretest probability of ILI being influenza, diagnostic test sensitivity, and treatment effectiveness.

Conclusions
Based on our model, treating high-risk patients presenting to hospital with influenza-like illness, without performing a novel rapid diagnostic test, resulted in the highest NHB and was most cost-effective. However, consideration of whether treatment is appropriate in the absence of diagnostic confirmation should be taken into account for decision-making by clinicians and policymakers.