bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of heart rate variability using 24‐hour Holter electrocardiography in hypertensive patients
Authors: Julario Rerdin , Mulia Eka Prasetya Budi , Rachmi Dita Aulia , A’yun Maya Qurota , Septianda Imanita , Dewi Ivana Purnama , Juwita Rahima Ratna , Dharmadjati Budi Baktijasa 
Published: November 2020

AbstractBackgroundHypertension (HTN) remains a serious risk factor for cardiovascular mortality across the world. Hypertensive state has been shown to be associated with autonomic nervous function. This study aimed to explore the association between autonomic nervous impairment assessed by heart rate variability (HRV) and HTN.MethodsA total of 52 hypertensive and 55 non‐hypertensive patients were consecutively studied using 24‐hour Holter. The hypertensive patients were grouped into controlled blood pressure (BP) and uncontrolled BP. This study compared HRV in non‐hypertensive and hypertensive patients; and hypertensive patients with controlled and uncontrolled BP. HRV parameters include time and frequency domain.ResultsMean age for hypertensive and non‐hypertensive patients were 53.58 ± 14.31 and 44.89 ± 16.63 years old, respectively. Median (IQR) SDNN for hypertensive and non‐hypertensive group were 109.00 (90.00‐145.00) and 129.00 (107.00‐169.00), respectively. SDNN, ASDNN, rMSSD, pNN50, BB50, VLF, and HF values were significantly lower in the hypertensive group compared to non‐hypertensive group (all P < .05). A multiple regression analysis showed that HRV parameters: SDANN, ASDNN, rMSSD, and LF values were independent risk factors of HTN. SDNN, SDANN, ASDNN, VLF, LF, and HF values were significantly lower in the uncontrolled BP compared to controlled BP group (all P < .05). A multiple regression analysis showed that HRV parameters: SDNN, SDANN, rMSSD, and HF values were independent risk factors of uncontrolled BP in hypertensive patients.ConclusionsOur study showed that cardiac autonomic nervous impairment, as demonstrated by reduced HRV, is significantly associated with HTN. Decreased HRV was more evident in uncontrolled BP than in controlled BP group.
Amplification of Winter Sea surface temperature response over East China Seas to global warming acceleration and slowdown
Authors: Tan Hongjian , Cai Rongshuo , Yan Xiuhua , Li Cuihua 
Published: November 2020

AbstractThe global mean surface temperature does not increase monotonously over the past decades, with accelerated warming from the late 1970s to 1998 and followed by the warming slowdown during 1998–2013 (the so‐called warming hiatus). This study assessed and compared the temporal evolutions of sea surface temperature (SST) trends in the East China Seas (ECS, including Bohai, Yellow and East China Sea) and other key ocean regions. The results revealed an amplified response of ECS SST to both global warming acceleration and hiatus. This amplification was manifested as remarkably enhanced winter warming rates in the ECS of over 1.1 and 0.8°C⋅decade–1 for the 1980–1989 and 1990–1999, respectively, and as an obvious cooling trend of nearly −0.5°C⋅decade‑1 during 1998–2013. The enhanced response can be explained well by the combined effects of the Kuroshio Current (KC) and East Asian Winter Monsoon (EAWM). The weakened EAWM during the 1980s, accompanied by lower wind speeds and higher air temperatures, impeded the releases of latent and sensible heat fluxes from the ocean to the atmosphere, resulting in rapid ECS warming. During 1998–2013, the strengthened EAWM led to the enhanced cooling trend in the ECS. In addition, the volume transport of the KC east of Taiwan strengthened (weakened) during the 1990s (2000s), which might also have contributed to the enhanced warming (cooling) in the ECS. Our research suggests their sensitivity makes the ECS potentially vulnerable to the effects of global climate change, which has important implications regarding regional impact assessments.
Sweetness Perception is not Involved in the Regulation of Blood Glucose after Oral Application of Sucrose and Glucose Solutions in Healthy Male Subjects
Authors: Grüneis Verena , Schweiger Kerstin , Galassi Claudia , Karl Corinna M. , Treml Julia , Ley Jakob P. , König Jürgen , Krammer Gerhard E. , Somoza Veronika , Lieder Barbara 
Published: November 2020

ScopeThis study investigates the effect of the sweetness of a sucrose versus an isocaloric glucose solution in dietary concentrations on blood glucose regulation by adjusting the sweetness level using the sweet taste inhibitor lactisole.Methods and ResultsA total of 27 healthy males participated in this randomized, crossover study with four treatments: 10% glucose, 10% sucrose, 10% sucrose + 60 ppm lactisole, and 10% glucose + 60 ppm lactisole. Plasma glucose, insulin, glucagon‐like peptide 1, and glucagon levels are measured at baseline and 15, 30, 60, 90, and 120 min after beverage consumption. Test subjects rated the sucrose solution to be sweeter than the isocaloric glucose solution, whereas no difference in sweetness is reported after addition of lactisole to the sucrose solution. Administration of the less sweet glucose solution versus sucrose led to higher blood glucose levels after 30 min, as reflected by a lower ΔAUC for sucrose (1072 ± 136) than for glucose (1567 ± 231). Application of lactisole leads to no differences in glucose, insulin, or glucagon responses induced by sucrose or glucose.ConclusionThe results indicate that the structure of the carbohydrate has a stronger impact on the regulation of blood glucose levels than the perceived sweetness.
Overexpression of exogenous biuret hydrolase in rice plants confers tolerance to biuret toxicity
Authors: Ochiai Kumiko , Uesugi Asuka , Masuda Yuki , Nishii Megumi , Matoh Toru 
Published: November 2020

AbstractBiuret, a common impurity in urea fertilizers, is toxic to plants, but little is known about the physiological mechanisms underlying its toxicity. Here, we analyzed biuret toxicity in rice (Oryza sativa) plants. We carried out uptake experiments using 15N‐labelled biuret and demonstrated that biuret could reach sub millimolar concentrations in rice plants. We also demonstrated that the hydrolysis of biuret in plant cells could confer biuret tolerance to rice plants. This occurred because transgenic rice plants that overexpressed an exogenous biuret hydrolase cloned from a soil bacterium gained improved tolerance to biuret toxicity. Our results indicate that biuret toxicity is not an indirect toxicity caused by the presence of biuret outside the roots, and that biuret is not quickly metabolized in wild‐type rice plants. Additionally, it was suggested that biuret was used as an additional nitrogen source in transgenic rice plants, because biuret hydrolase‐overexpressing rice plants accumulated more biuret‐derived N, as compared to wild‐type rice.
Potassium nutrition in oil palm: The potential of metabolomics as a tool for precision agriculture
Authors: Cui Jing , Chao de la Barca Juan Manuel , Lamade Emmanuelle , Tcherkez Guillaume 
Published: November 2020

Societal Impact StatementOil palm is the first oil‐producing crop globally, representing nearly 20 million ha. In the recent past, oil palm cultivation has been controversial not only because of land utilisation at the expense of primary tropical forests or health concerns associated with palm oil, but also pollution caused by fertilization (including CO2 produced to synthesise fertilizers). Oil palm fields are heavily fertilized with potassium (K), and thus finding better, more parsimonious methods to monitor K nutrition is more important than ever. Here, we suggest that metabolomics and subsequent machine learning of metabolic signatures represent a promising tool to probe K requirements, opening avenues for precision agriculture in oil palm industry.
Genome‐wide assessment and development of molecular diagnostic methods for imidacloprid‐resistance in the brown planthopper, Nilaparvata lugens (Hemiptera; Delphacidae)
Authors: Yokoi Kakeru , Nakamura Yuki , Jouraku Akiya , Akiduki Gaku , Uchibori‐Asano Miwa , Kuwazaki Seigo , Suetsugu Yoshitaka , Daimon Takaaki , Yamamoto Kimiko , Noda Hiroaki , Sanada‐Morimura Sachiyo , Matsumura Masaya , Cuong Le Quoc , Van Chien Ho , Estoy Gerardo F , Shinoda Tetsuro 
Published: November 2020

AbstractBACKGROUNDThe brown planthopper, Nilaparvata lugens (Stål), is one of the most notorious pests of rice throughout Asia. The brown planthopper has developed high resistance to imidacloprid, a member of neonicotinoid insecticides. Several genes and mutations conferring imidacloprid resistance in N. lugens, especially in eastern and southeastern Asia populations, have been reported. Thus, the key mechanisms of imidacloprid resistance need to be examined.RESULTSRNA‐seq analyses revealed that only one cytochrome P450 monooxygenase gene, CYP6ER1, was commonly upregulated in the five resistant strains tested. Sequences of CYP6ER1, which were highly expressed in the imidacloprid‐resistant strains, contained a three‐nucleotide deletion in the coding region, and amino acid substitutions and deletion, compared to that in an imidacloprid‐susceptible strain. RNAi‐mediated gene knockdown of CYP6ER1 increased imidacloprid susceptibility in a resistant strain. Further, we established two simple and convenient PCR‐based molecular diagnostic methods to detect the CYP6ER1 locus with the three‐nucleotide deletion. Using these methods, the resistance of F2 progenies derived from the crosses of F1 siblings from susceptible and resistant parents was analyzed, showing that the imidacloprid resistance had a relationship to the CYP6ER1 locus with the three‐nucleotide deletion.CONCLUSIONThe overexpression of a variant CYP6ER1 with amino acid substitutions and deletion was involved in imidacloprid resistance in N. lugens. Based on these findings, molecular diagnostic methods have been developed and are promising tools for monitoring imidacloprid resistance in paddy fields. © 2020 Society of Chemical Industry
“Rapunzel, Rapunzel,Lanza Tu Pelo”: Storytelling in a Transcultural, Translanguaging Dialogic Exchange
Authors: Flynn Erin E. 
Published: November 2020

ABSTRACTIn this study, we examined story circles to understand how the small‐group activity supports and shapes the storytelling of young students in multicultural, multilingual preschool classrooms. Through a representative example, we show how language development unfolds in the context of a transcultural and translanguaging dialogic exchange of stories. We describe features of increasing linguistic complexity present in students’ storytelling as they established affinity‐affirming connections over ideas, shared ways of languaging, and shared ways of storytelling. By examining changes in one student’s storytelling in the context of a mixed‐language story circle group, we offer insights into both language development and features of the language ecology in which such changes are supported.
The damselfly palaeofauna from the Eocene of Wyoming and Colorado, USA (Insecta, Odonata, Zygoptera)
Authors: Bechly Günter , Garrouste Romain , Aase Arvid , Karr Jered A. , Grande Lance , Nel André 
Published: November 2020

AbstractA new family, five new genera, and nine new species of fossil damselflies (Insecta, Odonata, Zygoptera, Calopterygida) from the USA are described, seven from the Eocene Fossil Lake deposits and one from Lake Uinta deposits, both from the Green River Formation, and an additional specimen from the Wind River Formation of Wyoming and Colorado. Namely, Carlea eocenica gen. et sp. nov. (in Carleidae fam. nov.), Labandeiraia riveri sp. nov., Labandeiraia browni sp. nov., Eodysphaea magnifica gen. et sp. nov., Litheuphaea sp. cf. coloradensis Petrulevičius et al., 2007, Zacallites cockerelli sp. nov., Dysagrion integrum sp. nov., Tenebragrion shermani gen. et sp. nov., Tynskysagrion brookeae gen. et sp. nov., and Oreodysagrion tenebris gen. et sp. nov. Epallagoidea and Amphipterygoidea are most common while Calopterygoidea, Coenagrionoidae and Lestoidea damselflies are less diverse. Genera of zygopteran Dysagrionidae are known from Europe and North America, further supporting the hypothesis of Palaeogene terrestrial interchange. Representatives of Epallagoidea and Amphipterygoidea in the Green River Formation confirm that warm conditions occurred at the time of deposition.
Four millennia of vegetation and environmental history above the Hyrcanian forest, northern Iran
Authors: Homami Totmaj Leila , Ramezani Elias , Alizadeh Kammaledin , Behling Hermann 
Published: November 2020

AbstractPast vegetation, fire, and climate dynamics, as well as human impact, have been reconstructed for the first time in the highlands of the Gilan province in the Alborz mountains (above the Hyrcanian forest) for the last 4,300 cal yrs bp. Multi-proxy analysis, including pollen, spores, non-pollen palynomorphs, charcoal, and geochemical analysis, has been applied to investigate the environmental changes at 2,280 m a.s.l., above the Hyrcanian forest. Dominant steppe vegetation occurred in the study area throughout the recorded period. The formation of the studied mire deposits, as well as vegetation composition, suggest a change to wetter climatic conditions after 4,300 until 1,700 cal yrs bp. Fires were frequent, which may imply long-lasting anthropogenic activities in the area. Less vegetation cover with a marked decrease of the Moisture Index (MI) suggests drier conditions between 1,700 and 1,000 cal yrs bp. A high proportion of Cichorioideae and Amaranthaceae, as well as the reduction of trees, in particular Fagus and Quercus, at lower elevations, indicate human activities such as intense livestock grazing and deforestation. Soil erosion as the result of less vegetation due to dry conditions and/or human activities can be reconstructed from a marked increase of Glomus spores and high values of K and Ti. Since 1,000 cal yrs bp, the increasing MI, as well as the rise of Poaceae and Cyperaceae together with forest recovery, suggest a change to wetter conditions. The occurrence of still frequent Cichorioideae and Plantago lanceolata along with Sordaria reflect continued intense grazing of livestock by humans.
Radio-luno-triquetral bone-ligament transfer as an additional stabilizer in scapholunate-instability
Authors: Haug Luzian C. P. , Adler Tom , Bignion Dietmar , Voegelin Esther 
Published: November 2020

AbstractIntroductionReconstruction of the scapho-lunate (SL) ligament is still challenging. Many different techniques, such as capsulodesis, tendon graft and bone-ligament-bone graft have been described to stabilize reducible SL dissociation. If primary ligament repair alone is not possible, an additional stabilizer is needed to achieve scapho-lunate stability. A new local bone-ligament transfer using half of the radio-luno-triquetral ligament is performed. The direction of traction of the transposed ligament is very similar to the original ligament. Ideal tension can be attained by fixation of the bone block at the dorsal ridge of the scaphoid. The biomechanical stability of this bone-ligament transfer shall be examined biomechanically.Material and methodsComputed tomography imaging was performed using eight cadaveric forearms with a defined position of the wrist. Axial load was accomplished with tension springs attached to the extensor and flexor tendons. Three series ([a] native, [b] divided SL ligament and [c]) after reconstruction with bone-ligament transfer] were reconstructed three-dimensionally to determine the angles between radius, scaphoid and lunate. The radial distal part including a bone fragment of the radio-luno-triquetral ligament was transferred from its insertion at the distal edge of the radius to be attached to the dorsal ridge of the scaphoid.ResultsSL gap was widened after its transection. Average SL distance was 6.6 ± 1.6 mm. After ligament reconstruction, the gap could be narrowed significantly to 4.2 mm (± 0.7 mm). The movement of the scaphoid and lunate showed significant changes, especially in wrist flexion, fist closure and radial deviation. These deviations could be corrected by the bone ligament transfer.ConclusionReconstruction of a transected SL ligament with a bone-ligament transfer from the radio-luno-triquetral ligament reduces SL dissociation under axial load. The described surgical technique causes low donor-side morbidity and can be considered in addition to improve stability if SL ligament suture alone does not appear sufficient.Level of evidenceLevel II, therapeutic investigating experimental study.
Who is Best at Mediating a Social Conflict? Comparing Robots, Screens and Humans
Authors: Druckman Daniel , Adrian Lin , Damholdt Malene Flensborg , Filzmoser Michael , Koszegi Sabine T. , Seibt Johanna , Vestergaard Christina 
Published: November 2020

AbstractThe impacts of various mediation platforms on negotiation outcomes and perceptions are compared in this article. The mediator platforms contrasted were a (teleoperated) Telenoid robot, a human, and a computer screen. All of these platforms used the same script for process diagnosis, analysis, and advice on how to resolve an impasse in a simulated high-tech company de-merger negotiation. A fourth experimental condition consisted of a no-mediation control. More agreements and more integrative agreements were attained by the robotic platform than by the other types of mediator platforms and the control. Mediation via the Telenoid robot also produced more non-structured agreements, which consisted of decisions made outside of the scenario options. Negotiators in this condition had more positive perceptions of the mediation experience, were more satisfied with the outcome, and thought that the mediator’s advice was more useful. Indirect analyses showed that the outcomes mediated the effects of the conditions on perceived satisfaction. Implications of the findings are discussed in terms of responses to novelty, which include creative and divergent modes of thinking.
Kelp in IMTAs: small variations in inorganic nitrogen concentrations drive different physiological responses of Saccharina latissima
Authors: Rugiu L. , Hargrave M. S. , Enge S. , Sterner M. , Nylund G. M. , Pavia H. 
Published: November 2020

AbstractKelps can be included in integrated multitrophic aquaculture (IMTA) where their growth and quality might benefit from the nutrient load released by other species like finfish and mussels transforming effluents from the cultured animals into valuable products. We studied how different nutrient concentrations affect growth, photosynthesis, chemical composition and pigment content of the kelpSaccharina latissima. We exposed kelps to natural seawater, water enriched to levels of ammonium and nitrate simulating finfish cage waste (IMTA1) and a combination of such enrichment with natural effluents coming from mussels (IMTA2). The algal biomass was higher and produced elevated total organic content when exposed to both IMTA1 and IMTA2. The photosynthetic responses in terms of relative electron transfer rate (rETRmax), PSII saturation irradiance (Ek) and total nitrogen content were also positively affected by both IMTA1 and IMTA2. We found a significant enhancement in pigment content only when algae were exposed to the strongest enrichment of our study (IMTA2). Finally, we found a positive relationship between rETRmaxand growth, and the content of chlorophyllaand fucoxanthin. Our results show significant physiological responses ofS. latissimato nutrient enrichment mimicking IMTA settings, as well as the benefit of added nutrients through a boost in photosynthetic activity that leads to higher kelp biomass and pigment production. This study suggests that modest nitrogen enrichment such as the one in our IMTA2 setup is enough to generate not only higher kelp biomass, but also an increased biomass quality with potentially higher market value.
Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide
Authors: Campiche Remo , Pascucci Francesca , Jiang Lily , Vergne Thibault , Cherel Marie , Gougeon Sarah , Préstat-Marquis Elodie , François Ghislain , Laurent Guillaume , Gempeler Mathias 
Published: November 2020

AbstractExpression wrinkles form over time due to repeated facial movements such as smiling and frowning. They have an imprint on facial skin in areas such as the corner of the eyes, where they take the form of crow’s feet, the forehead and the glabella, where they appear as frown lines, and around the mouth, as marionette lines. In the study presented here, we recruited two sets of volunteers. An older group of 57 volunteers aged 50 to 65 years, and a group of eight younger volunteers aged 21–35 who were the biological daughters of eight of the older volunteers. Using VISIA CR, we took images of the volunteers in relaxed, angry and smiling mode to assess similarities in expression wrinkle patterns. In addition, the older volunteers were split into a placebo group and an active group who applied a formulation of 4% of a cosmetic product containing the peptide diaminobutyroyl benzylamide diacetate (DABBA) for four weeks. Wrinkles were assessed by image analysis, expert grading and Primoslite measurements. Our study found striking similarities in the facial wrinkle patterns of mothers with relaxed faces and daughters with angry or smiling faces. We found a decrease in visible wrinkles in the group of older volunteers applying DABBA. We created a facial map for graded wrinkles showing these changes. Volunteers using the active formulation showed significantly less wrinkle area and length on the forehead when frowning compared to the placebo group (p < 0.05).
GPs’ views on the use of depression screening and GP-targeted feedback: a qualitative study
Authors: Braunschneider Lea-Elena , Lehmann Marco , Magaard Julia Luise , Seeralan Tharanya , Marx Gabriella , Eisele Marion , Scherer Martin , Löwe Bernd , Kohlmann Sebastian 
Published: November 2020

Abstract
Purpose
The first aim of this qualitative study was to identify general practitioners’ (GPs’) views on depression screening combined with GP-targeted feedback in primary care. The second aim was to determine the needs and preferences of GPs with respect to GP-targeted feedback to enhance the efficacy of depression screening.

Methods
A semistructured qualitative interview was conducted with officially registered GPs in Hamburg (Germany). Interviews were audio recorded and transcribed verbatim. An inductive approach was used to code the transcripts.

Results
Nine GPs (27 to 70 years; 5 male) from Hamburg, Germany, participated. Regarding depression screening combined with GP-targeted feedback, five thematic groups were identified: application of screening; screening and patient–physician relationships; GPs’ attitudes towards screening; benefits and concerns related to screening; and GPs’ needs and preferences regarding feedback. While the negative aspects of screening can be described in rather general terms (e.g., screening determines the mental health competence, screening threatens the doctor–patient relationship, revealing questions harm the patients), its advantages were very specific (e.g., promoting the identification of undetected cases, relief of the daily workload, wider communication channel to reach more patients). Standardized GP-targeted feedback of the screening results was perceived as helpful and purposeful. GPs preferred feedback materials that eased their clinical workload (e.g., short text with visuals, pictures, or images).

Conclusion
Addressing GPs’ needs is essential when implementing depression screening tools in clinical practice. To overcome prejudices and enhance the efficacy of screening, further education for GPs on the purpose and application on depression screening may be needed. Standardized GP-targeted feedback in combination with depression screening could be the missing link to improve the detection of depression in primary care.