bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFIL PENGETAHUAN MAHASISWA INSTITUT TEKNOLOGI SEPULUH NOPEMBER TERHADAP PENGGUNAAN OBAT ANTASIDA
Authors: Susetyo Ersalia , Agustin Ermawati Dwi , Hanuni Hurindina , Chasanah Rafiqa Amalia , Lestari Elda Yuliana Dwi , Rana Rana , Leo Yehezkiel Alfa Ludji , Rizqulloh Zulfia Almas , Meldaviati Galina , Fardha Jamilatul , Febriansyah Ferri , Susanto Didy Pratama Maylana , Sholikah Faridatus , Pristianty Liza 
Published: September 2020

Obat terapi gastritis yang banyak digunakan di kalangan mahasiswa adalah antasida. Pengetahuan tentang antasida berpengaruh terhadap ketepatan penggunaan obat antasida yang berdampak pada keberhasilan terapi. Penelitian ini bertujuan mengetahui profil pengetahuan mahasiswa Institut Teknologi Sepuluh Nopember terhadap penggunaan obat antasida. Penelitian ini bersifat observasi melalui metode survei menggunakan instrumen kuesioner, berdasarkan waktu cross sectional. Sejumlah 130 orang sampel diambil dengan menggunakan teknik accidental sampling. Data dianalisis dengan cara skoring jawaban pertanyaan kuesioner. Hasil penelitian menunjukkan bahwa mahasiswa dengan pengetahuan penggunaan obat antasida yang baik sebesar 61(47%) orang dan pengetahuan cukup 69(53%) orang, sedangkan dari total responden tersebut yang pernah mengalami maag sebanyak 84 (66%) orang dan sisanya sebanyak 44(34%) orang belum pernah mengalaminya. Sejumlah 75 (58%) orang mendapatkan obat dari apotek, sedangkan sisanya memperoleh dari tempat lain. Pengetahuan yang baik tentang penggunaan obat akan meningkatkan keberhasilan terapi. Upaya promosi kesehatan merupakan hal penting untuk meningkatkan pengetahuan mahasiswa tentang penggunaan obat antasida yang benar.
Characteristics of Atrial Fibrillation Based On Age, Sex, and Etiology
Authors: Husniyah Barizatul , Herwanto Bambang , Handajani Noor Idha 
Published: September 2020

Introduction: Atrial fibrillation (AF) is one type of arrhythmia that occurs frequently to patients in the last decade. AF patients have five times higher risk to stroke and death, and they also have two times higher risk compared to others. A correct selection of governance in AF could result in better prognosis of the patients. The aim of this study was to explain AF of the outpatients in Department of Cardiology of Dr. Soetomo General Hospital Surabaya in February 2018, so that it can detect early AF and prevent further advanced complications. Methods: This research was descriptive method design. The population and sample of this study included all of the patients who had AF and came to out-patient care in Department of Cardiology of Dr. Soetomo General Hospital Surabaya in February 2018. This research was real-time total sampling and was analyzed descriptively.Results: In this study, 60 samples which were suitable to the criteria were gained with the numbers of 25 males (41.7%) and 35 females (58.3%). AF attacked more patients in age 51-60 years old (31.7%). The most common etiology of AF is rheumatic heart disease (60%).Conclusion: Most of AF patients in this study were 51-60 years old, female, and were caused by rheumatic heart disease. With the lack information, it still needed further studies with more complete data for better accuracy.
Pembelajaran Mahārat al-Kalām pada Program Kursus Bahasa Arab Spesial Ramadan di Pesantren Darul Lughah Waddirasatil Islamiyah, Pamekasan, Madura
Authors: Mahbub Humaidi Aziz  , M. Syathibi Nawawi  , Muhammad Alfan  
Published: September 2020

The purpose of this study was to determine the learning process (material, methods, media, and evaluation), effectiveness, and efficiency of learning mahārat al-kalām on the Ramadan Special Arabic course program at Pondok Pesantren Darul Lughah Waddirasatil Islamiyah (PP DLWI), Pamekasan, Madura. Data collection techniques used were observation, interviews, questionnaires, and documentation. Qualitative data were analyzed using descriptive methods, while quantitative data used simple statistics consisting of the stages of preparation, tabulation, and data processing. The results of this study prove that (1) the learning process of mahārat al-kalām consists of materials, methods, media, and evaluations that are tailored to each level; mubtadi’, mutawassiṭ, and mutaqaddim; (2) the effectiveness of mahārat al-kalām learning in this program is, the mubtadi’ level of 87.33% (very effective), the mutawassiṭ rate of 95.6% (very effective), and the mutaqaddim rate of 98% (very effective); (3) The efficiency of mahārat al-kalām learning in this program is, the mubtadi’ level of 88.25% (very efficient), the mutawassiṭ rate of 90.88% (very efficient), and the mutaqaddim rate of 94.05% (very efficient).
Out-of-hours workload among Norwegian general practitioners – an observational study
Authors: Rebnord Ingrid Keilegavlen , Morken Tone , Maartmann-Moe Kjell , Hunskaar Steinar 
Published: September 2020

Abstract
Background: Repeated studies of working hours among Norwegian regular general practitioners (RGPs) have shown that the average total number of weekly working hours has remained unchanged since 1994 and up until 2014. For both male and female RGPs, the mean total weekly working hours amounted to almost 50 hours in 2014. In recent years, Norwegian RGPs have become increasingly dissatisfied. They experience significantly increased workload without compensation in the form of more doctors or better payment. A study from the Norwegian Directorate of Health in 2018 (the RGP study) showed that Norwegian RGPs worked 55.6 hours weekly (median 52.5). 25% of the respondents worked more than 62.2 hours weekly. Based on data from the RGP study we investigated Norwegian RGP’s out-of-hours (OOH) work, how the working time was distributed, and to what extent the OOH work affected the regular working hours.Methods: In early 2018, an electronic survey was sent to all 4640 RGPs in Norway. Each RGP reported how many minutes that were spent that particular day on various tasks during seven consecutive days. Working time also included additional tasks in the municipality, other professional medical work and OOH primary health care. Differences were analysed by independent t-tests, and regression analyses. Results: 1876 RGPs (40.4%) responded, 640 (34.1%) had registered OOH work. Male RGPs worked on average 1.5 hours more doing regular work than did females (p=0.001) and on average 2.3 hours more OOH work than females (p=0.079). RGPs with no OOH work registered a mean of 1.0 hours more clinical work than RGPs working OOH (p=0.043). There was a large variation in OOH working hours. A linear regression analysis showed that male RGPs and RGPs in rural areas had the heaviest OOH workload. ﻿Conclusions: One in three Norwegian RGPs undertook OOH work during the registration week in the RGP study. OOH work was done in addition to a sizeable regular workload as an RGP. We found small gender differences. OOH work was not compensated with reduced regular RGP work.
Trends in Male Contraceptive Use in Ghana: An Analysis of Self-Reported Contraceptive Use from GDHS 2003, 2008 and 2014
Authors: Alando Cyril , Manu Adom , Habib Helen , Modey Emefa , Torpey Kwasi , Adanu Richard , Ankomah Augustine 
Published: September 2020

Abstract
Background: Male participation in contraception is proven to have positive outcomes on reproductive health and remains a critical issue of public health importance. However, there is a dearth of evidence on men’s share of the contraceptive burden among couples in Ghana. Knowledge of the trends and trajectories of men’s contraceptive practice could inform male focused programmatic interventions to boost contraceptive use for effective fertility regulation. This study examined the trends in contraceptive use as reported by men. Methods: This paper examines trends in self-reported contraceptive use among sexually active Ghanaian males, using data from the three most recent national Demographic and Health Surveys (2003, 2008 and 2014). Frequency distributions of socio-demographic and background characteristics were used to describe the sample by each survey year. The Z test of proportions was used to identify significant differences in the estimated proportions and subgroups of men using contraceptives by survey year. The Combined data from the three nationally representative surveys were analyzed, accruing a sample of 9,008, comprising (GDHS 2003=3,104; GDHS 2008=3,007; and GDHS 2014=2,897) male respondents who met the inclusion criteria.Results: Men’s contraceptive use appears to have declined over the last three demographic surveys despite an increase in the proportion of sexually active males. However, a significant proportion of men who used contraception (44.5% - 41.5%) still relied on the male condom as their primary choice of contraception. Place of residence, educational attainment, occupation, region of residence and religious affiliation were all found to be significantly associated with contraceptive use consistency.Conclusion: There has been a significant decrease in contraceptive use by Ghanaian men between 2003 and 2014. Although the male condom appears to be the most popular modern male contraceptive method, especially during adolescence, along the life course the phenomenon changes, with a shift towards modern female methods. There is therefore, the need for family planning service providers, policymakers and all relevant stakeholders to consciously target men with contraceptive products and services and community engagement to improve FP uptake
All-in-one dual CRISPR-Cas12a (AIOD-CRISPR) assay protocol for SARS-CoV-2 detection
Authors: Ding Xiong , Yin Kun , Li Ziyue , Lalla Rajesh V. , Sfeir Maroun M. , Liu Changchun 
Published: September 2020

Abstract
This protocol presents the all-in-one dual CRISPR-Cas12a (AIOD-CRISPR) assay to ultra-sensitively and visually detect SARS-CoV-2. The procedure of AIOD-CRISPR assay typically consists of three parts including sample preparation, AIOD-CRISPR reaction, and fluorescence detection. Sample preparation involves the synthetic RNA preparation and the nucleic acid extraction from SARS-CoV-2 samples. The prepared nucleic acids were then added into the AIOD-CRISPR reaction systems as templates, followed by incubation at 37°C for 20-40 min. After incubation, visual detection was immediately conducted by placing the tubes in a portable LED blue transilluminator (Maestrogen UltraSlim) or the ChemiDoc™ MP Imaging System (Bio-Rad) with its built-in UV channel. In addition to endpoint visual detection, real-time fluorescence detection was also available for AIOD-CRISPR assay. This protocol is helpful for applying AIOD-CRISPR assay to rapid, sensitive, one-pot point-of-care SARS-CoV-2 detection.
Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model
Authors: Li Naijian , Yang Zhaowei , Liao Baoling , Pan Tianhui , Pu Jinding , Hao Binwei , Fu Zhenli , Cao Weitao , Zhou Yuming , He Fang , Li Bing , Ran Pixin 
Published: September 2020

Abstract
Background: The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified.Results: After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide.Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.
Predictors of resignation and sick leave after cancer dianosis among Japanese breast cancer survivors: a cross-sectional study
Authors: Mitsui Kiyomi , Endo Motoki , Imai Yuya , Ueda Yuito , Ogawa Hiroko , Muto Go , Yan Yan , Deshpande Gautam A. , Terao Yasuhisa , Takeda Satoru , Tanigawa Takeshi , Nishimura Katsuji , Hayashi Kazuhiko , Saito Mitsue , Kokaze Akatsuki 
Published: September 2020

Abstract
Background: In Japan, 55.5% of breast cancer survivors (BCSs) are of working age, so various perspectives regarding return to work (RTW) after cancer diagnosis need to be considered. Therefore, this study aimed to clarify the risk factors for resignation and taking sick leave (SL) among BCSs in continued employment at the time of diagnosis.Methods: A web-based retrospective cross-sectional survey was conducted on BCSs using data from a 2018 Japanese national research project (Endo-Han) commissioned by the Ministry of Health, Labour and Welfare of Japan. The subjects were women aged 18–69 years who had been diagnosed with breast cancer for the first time at least 1 year previously. The risk factors for resignation and taking SL after breast cancer diagnosis, including age at diagnosis, education level, cancer stage, surgery, chemotherapy, radiotherapy, employment status, and occupational type, were then analyzed using a logistic regression model.Results: In total, 40 (14.9%) of 269 BCSs quit their jobs at least 1 year after being diagnosed with breast cancer. The results of the multivariable analysis indicated that lower education level (odds ratio [OR]: 3.802; 95% confidence interval [CI]: 1.233–11.729), taking SL (OR: 2.514; 95%CI: 1.202–5.261), and younger age at diagnosis (OR: 0.470; 95%CI: 0.221–0.998) were predictors of resignation. Of 229 patients who continued working, SL was taken by 72 (31.4%). In addition, undergoing surgery was found to be a predictor of taking SL (OR: 8.311; 95%CI: 1.007–68.621).Conclusions: In total, 40 (14.9%) of 269 BCSs quit their jobs at least 1 year after being diagnosed with breast cancer. The results of this study indicated that younger age, lower education level, and taking SL were predictors of resignation after breast cancer diagnosis.
Primarily Treated Patients versus Referred Patients in the Treatment of Native Septic Arthritis of Digits: A Retrospective Comparative Study
Authors: Kwak Sang Ho , Bae Jung Yun , Oh Youngkwang , Jang Hyo Seok , Ahn Tae Young , Lee Sang Hyun 
Published: September 2020

Abstract
Background Septic arthritis of digits needs urgent treatment. When treatments delayed or insufficient, patients may be referred to the upper-level hospital due to uncontrolled infection. We reviewed the treatment history of referred patients and compared the microorganisms and the clinical course of both primary and referred patients as relevant studies are rare. Methods In this retrospective review of consecutive case series, 45 patients (primary, n=11; referred, n=34) were treated with multiple irrigation and debridement. Cefazolin was used as empiric antibiotics, then changed according to microbiologic study. Previously used antibiotics, treatment delay, surgical history of the referred patients were reviewed. Identified microorganisms, required surgical intervention, hospital stay, radiologic outcome, functional outcomes were compared between both groups. Results In the referred patients, methicillin-resistant Staphylococcus aureus (MRSA) was commonly found and cefazolin was susceptible in only 15% of the cases. Longer hospital stay, prolonged antibiotic therapy, more surgical intervention including flap surgery was required to treat the referred patients. Postoperative pain was not severe in daily activities, but the final range of motion was significantly less in the referred patients compared to the primary patients.Conclusions This study suggests that in the treatment of uncontrolled septic arthritis of the digits, antibiotic agents covering MRSA may shorten the duration of antibiotic therapy in areas of high MRSA incidence. Besides, more number of I & D including flap surgery may be required for the referred patients compared with the primary patients. These findings can help the surgeon in setting up a treatment plan or in counseling of referred patients with uncontrolled septic arthritis of the digits.
Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases
Authors: Pereira Leonn Mendes Soares , Madureira Max Willy da Silva , de Castro Renata Bezerra Hermes , Abreu Isabella Nogueira , Conde Simone Regina Souza da Silva , Demachki Sâmia , de Sousa Maisa Silva , Queiroz Maria Alice Freitas , Silva Andrea Nazaré M. Rangel da , Ishak Marluísa de Oliveira Guimarães , Ishak Ricardo , Vallinoto Antonio C. R. 
Published: September 2020

Abstract
Background: The forkhead box protein 3 (FOXP3) transcription factor is one of the main markers of immunological suppression in different pathological profiles, and the presence of polymorphic variants may alter the gene expression of this factor. Despite descriptions of an association between the presence of the rs2232365 polymorphism and chronic diseases, the role of the sex variant in this context has not yet been elucidated, as the FOXP3 gene is located on the human sex chromosome X. Results: To contribute to this topic, 323 women and 373 men were enrolled in the study, of which 101 were diagnosed with chronic viral liver diseases (39 women and 62 men), 67 with HTLV-1 infection (44 women and 23 men), 230 with coronary artery disease (91 women and 139 men) and 298 healthy and uninfected blood donors (149 women and men). They were genotyped for the rs2232365 polymorphism. The rs2232365 polymorphism was associated with clinical and pathological aspects and biomarkers of viral infections only in men, with functional differences between different infections. Conclusions: A relationship is suggested between sex and FOXP3 rs2232365 polymorphism, resulting in different biological repercussions.
The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice
Authors: Yang Liu , Liu Sijie , Han Silu , Hu Yuhan , Wu Zhipeng , Shi Xiaoqian , Pang Baosen , Ma Yingmin , Jin Jiawei 
Published: September 2020

Abstract
Background: Septic-acute respiratory distress syndrome (ARDS), characterized by the acute lung injury (ALI) secondary to aberrant systemic inflammatory response, has high morbidity and mortality. Despite increased understanding of ALI pathogenesis, the therapies to prevent lung dysfunction underlying systemic inflammatory disorder remain elusive. The high density lipoprotein (HDL) has critical protective effects in sepsis and its dysfunction has a manifested contribution to septic organ failure. However, the adverse changes in HDL composition and function in septic-ARDS patients are large unknown.Methods: To investigate HDL remodeling in septic-ARDS, we analyzed the changes of HDL composition from 40 patients with septic-ARDS (A-HDL) and 40 matched normal controls (N-HDL). To determine the deleterious functional remodeling of HDL, A-HDL or N-HDL was administrated to C57BL/6 and apoA-I knock-out (KO) mice after cecal ligation and puncture (CLP) procedure. Mouse lung microvascular endothelial cells (MLECs) were further treated by these HDLs to investigate whether the adverse effects of A-HDL were associated with endothelial dysfunction.Results: Septic-ARDS patients showed significant changes of HDL composition, accompanied with significantly decreased HDL-C. We further indicated that A-HDL treatment aggravated CLP induced ALI. Intriguingly, these deleterious effects of A-HDL were associated with pulmonary endothelial dysfunction, rather than the increased plasma lipopolysaccharide (LPS). Further in vitro results demonstrated the direct effects of A-HDL on MLECs, including increased endothelial permeability, enhanced expressions of adhesion proteins and pro-inflammatory cytokines via activating NF-κB signaling and decreased junction protein expression.Conclusions: Our results depicted the remodeling of HDL composition in sepsis, which predisposes lung to ARDS via inducing ECs dysfunction. These results also demonstrated the importance of circulating HDL in regulating alveolar homeostasis.
Quantitative CT-based Image Registration Metrics Provide Different Ventilation and Lung Motion Patterns in Prone and Supine Positions in Healthy Subjects
Authors: Shin Kyung Min , Choi Jiwoong , Chae Kum Ju , Jin Gong Yong , Eskandari Ali , Hoffman Eric A. , Hall Chase , Castro Mario , Lee Chang Hyun 
Published: September 2020

Abstract
Background Previous studies suggested that the prone position (PP) improves oxygenation and reduces mortality among patients with acute respiratory distress syndrome (ARDS). However, the mechanism of this clinical benefit of PP is not completely understood. The aim of the present study was to quantitatively compare regional characteristics of lung functions in the PP with those in the supine position (SP) using inspiratory and expiratory computed tomography (CT) scans.Methods 90 subjects with normal pulmonary function and inspiration and expiration CT images were included in the study. Thirty-four subjects were scanned in PP, and 56 subjects were scanned in SP. Non-rigid image registration-based inspiratory-expiratory image matching assessment was used for regional lung function analysis. Tissue fractions (TF) were computed based on the CT density and compared on a lobar basis. Three registration-derived functional variables, relative regional air volume change (RRAVC), volumetric expansion ratio (J), and three-dimensional relative regional displacement (s*) were used to evaluate regional ventilation and deformation characteristics. Results J was greater in PP than in SP in the right middle lobe (P = 0 .025), and RRAVC was increased in the upper and right middle lobes (P < 0.001). The ratio of the TF on inspiratory and expiratory scans, J, and RRAVC at the upper lobes to those at the middle and lower lobes and that ratio at the upper and middle lobes to those at the lower lobes of were all near unity in PP, and significantly higher than those in SP (0.98-1.06 vs 0.61-0.94, P < 0.001).Conclusion We visually and quantitatively observed that PP not only induced more uniform contributions of regional lung ventilation along the ventral-dorsal axis but also minimized the lobar differences of lung functions in comparison with SP. This may help in the clinician’s search for an understanding of the benefits of the application of PP to the patients with ARDS or other gravitationally dependent pathologic lung diseases.Trial registration Retrospectively registered.