bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembrolizumab-induced Guillain-Barré syndrome in triple-negative breast cancer: A case report
Authors: Cherukuri Phani Bhavana , Tayyeb Muhammad , Gaddameedi Sai Rakshith , Du Doantrang , Meghal Trishala 
Published: December 2024

BACKGROUND
The programmed cell death protein 1 inhibitor pembrolizumab has become a key treatment for various cancers, including triple-negative breast cancer. However, it is associated with immune-related adverse events, including rare but serious neurological complications such as Guillain-Barré syndrome (GBS). GBS is a potentially life-threatening autoimmune disorder characterized by muscle weakness and paralysis. We present a unique case of pembrolizumab-induced GBS to highlight the importance of recognizing this complication and managing it promptly in patients receiving immune checkpoint inhibitors.
CASE SUMMARY
A 69-year-old woman with a medical history of hypertension, anxiety, depression, and stage IIIB triple-negative breast cancer treated with pembrolizumab, carboplatin, and paclitaxel, presented to the emergency department with a 1-month history of tingling, lower extremity weakness, and shooting pain. Symptoms progressed to global weakness, ascending paralysis, and double vision. Neurological examination revealed significant lower extremity weakness and sensory deficits. Magnetic resonance imaging of the lumbar spine and cerebrospinal fluid analysis confirmed GBS. Initial treatment with intravenous immunoglobulin led to relapse, requiring additional intravenous immunoglobulin and high-dose glucocorticoids. The patient’s condition improved, pembrolizumab therapy was permanently discontinued, and she was discharged to a rehabilitation facility.
CONCLUSION
Pembrolizumab can induce GBS, necessitating early recognition, prompt diagnosis, and multidisciplinary management to prevent serious complications.
تأثير تمرينات خاصة على وفق مؤشر النبض في تطوير بعض المؤشرات الوظيفية والقوة الانفجارية للاعبي الكرة الطائر
Authors: ايثار حمدي عبد الرحمن  
Published: December 2024

هدف البحث التعرف على مستوى القدرات البدنية لدى أفراد عينة البحث، وتحديد أفضل فترات راحة على وفق مؤشري النبض (120 ن/د أو 130 ن/د) في تنميتها والمؤشرات الوظيفية وفرض الباحث بان هناك فروق ذات دلالة إحصائية بين الاختبارين القبلي والبعدي واشتملت عينة البحث لاعبي نادي هيت الرياضي بالكرة الطائرة أحد أندية الدوري الممتاز العراقي للموسم (2022- 2023) والبالغ عددهم (16) لاعباً. واستخدم الباحث المنهج التدريبي لملائمته وطبيعة مشكلة البحث واستنتج الباحث بان البرنامج التدريبي المعد كان فعالاً وايجابياً للعمل على وفق مؤشر النبض (120ن/د). وشملت الاستنتاجات ،كان تأثير المستوى وفق مؤشر النبض (120ن/د).وتحسين مستوى النبض قبل الجهد في الراحة التامة، وبعد مرور (60 ثا) وبعد مرور (90 ثا)، ولكن مستوى التحسن في اسلوب عودة النبض (130ن/د) كان افضل من اسلوب عودة النبض (120ن/د).وشملت التوصيات ،العمل على استخدام أسلوب التمارين على وفق مؤشري النبض اللذين استخدمها الباحث في مفردات المنهاج التدريبي الذي يعمل به مستقبلاً في الفعاليات الرياضية الاخرى. وضرورة اجراء اختبارات فسلجيه لتقنين الأحمال التدريبية لما لها من دور فاعل في العملية التدريبية. وهذا ما يحقق احد اهداف التنمية المستدامة للامم المتحدة في العراق (الصحة الجيدة).
Epidemiologia crítica ao uso de metilfenidato e substâncias correlatas entre acadêmicos sem diagnóstico de transtorno de déficit de atenção e hiperatividade em um Centro Universitário do Oeste do Paraná
Authors: Gonzaga Camily Rayssa Gomes , Oliveira Clarissa Vasconcelos de 
Published: December 2024

O metilfenidato e a lisdexanfetamina, são substâncias estimulantes do sistema nervoso central, dispensadas pelos nomes comerciais de Ritalina® e Venvanse®, respectivamente. Entre as indicações de uso clínico desses fármacos encontra-se o tratamento do Transtorno de Déficit de Atenção e Hiperatividade (TDAH), pois como mecanismo de ação primário, ambos têm a capacidade de mimetizar os efeitos de liberação das catecolaminas no organismo. Devido a ação no sistema nervoso central (SNC), os dois são medicamentos sujeitos a controle especial, uma vez que apresentam risco de uso abusivo e dependência. Em decorrência da ação central estimulante, nos últimos anos ocorreu um aumento do uso não terapêutico dos referidos fármacos por estudantes, com o objetivo de melhorar ou incrementar a performance cognitiva. Os dados encontrados apontaram para um percentual de 25,5% de alunos que fizeram uso de metilfenidato, 9,1% que utilizaram a lisdexanfetamina e 21,8% que fizeram uso de ambos. A análise acerca do uso não prescrito desses medicamentos se faz necessária para que se possa pensar em estratégias a fim de mitigar esse fato.
Análise crítica e perspectivas da legislação ambiental no vale do São Patrício, Goiás, Brasil
Authors: Oliveira João Donizetti Borges de , Silva Claudiane Alves da , Matos Keren Morais de Brito , Lima Charles Ribeiro , Peixoto Josana de Castro 
Published: December 2024

Localizado na região centro-norte do Estado de Goiás, o Vale do São Patrício teve um processo de colonização tardio, intensificado na segunda metade do século XX, graças aos estímulos dados pelo governo através da criação da Colônia Agrícola Nacional de Goiás (CANG). Com o intuito de fixar os colonos nas terras recém-doadas foi criada toda uma estrutura de apoio composta por hospital, escola e alguns outros serviços básicos que atraíram muitas famílias provenientes em sua maioria da região sudeste. Deu origem a três cidades; Ceres, Nova Glória e Ipiranga de Goiás. Ceres, a maior dentre as três, tornou-se um a referência na prestação de serviços para a região, notadamente nas áreas de saúde e educação. Importante fornecedor de grãos para grandes centros consumidores do Brasil, a região viu a sua produção antes diversificada se transformar em quase que monocultura, ligada a cana-de-açúcar. Várias usinas se instalaram na região, o que desestimulou os produtores locais em continuarem a investir na produção agropecuário, o que tornou a região, antes autossuficiente e exportadora de grãos, em dependente da produção trazida de outras regiões. Essa realidade tem trazido vários e sérios problemas ambientais, notadamente no desmatamento de áreas nativas que dão lugar a grandes plantações e a questão da água usada para irrigação das culturas e também do descarte feito dos resíduos da atividade produtiva. A região apresenta poucas áreas de preservação de mata nativa e poucos projetos de recuperação de áreas degradadas, motivo de preocupação que impulsionou o presente trabalho. Com o objetivo de realizar um estudo analítico da legislação ambiental aplicada no Vale do São Patrício e como isso implicou nas transformações socioambientais e econômicas. Observou-se que as ações de proteção e preservação ao meio ambiente nos municípios do Vale do São Patrício ainda encontram se em fase de implementação e, faz-se necessário uma exequibilidade expressiva para o cumprimento da legislação acerca de diferentes categorias como gerenciamento de resíduos sólidos e proteção ambiental.
Pengaruh Dukungan Organisasi dan Disiplin Kerja Terhadap Kinerja Pegawai pada Kantor Badan Perencanaan Penelitian dan Pengembangan (BAPELITBANG) Kabupaten Sikka
Authors: Agustina Nona Leli  , Imanuel Wellem  , Yustina Olivia Da Silva  
Published: December 2024

This This Study aimed to (1) understand the overview of employe, performance, Organizational support, and work discipline, and (2) analyze the influence of organizational support and work discipline on employee performace both partially and simultaneously. The population in this study consisted of 40 employees of the Regional Planning, Research, and Development Agency (BAPELITBANG) of the Sikka Regency. Due to the limited population, the study was conducted using a census or saturated samping method. Data were collected through questionnaires and analyzed using descriptive and infertial statistical methods, specificallymultiple linear regression. Hypothesis testing was conducted using f- tesr and t-test. The results of the descriptive analysis indicated that the employee performance variable was categorized as good, the organizational support variable was also categorized as good,and the work discipline variable was categorized as good as well. The results of the t-test showed that partially,the organizational support variable had a positive and significant effect on employee performance. Additionally, the work discipline variable had a positive and significant effect and employee performance.the result of the f-test showed that simultaneously, the organizational support and the work discipline variables had a significant effect on employee performance. The determination analysis results indicated that the two independent variables in this study could explain 23,4% of the variation in the rise and fall of employee performance at the regional planning, Reseach, and Development Agency ( BAPELITBANG) of Sikka Regency.
Strategi Pengembangan dan Pemasaran Saham Syariah di Pasar Modal Berbasis Teknologi Digital
Authors: Dini Selasi  , Adine Ardiyanti  , Siti Khoiriyah  
Published: December 2024

The sharia capital market has become an important component in supporting sharia-based economic growth. With the rapid development of digital technology, implementing innovative strategies is the key to expanding reach and increasing efficiency in developing and marketing sharia shares. This research aims to identify and formulate effective strategies in developing and marketing sharia shares in digital technology-based capital markets. The research method used is a literature study, which analyzes various literature and secondary data regarding current practices in the Islamic capital market and the adoption of digital technology in this sector. The research results show that the adoption of digital technology, such as online trading platforms and artificial intelligence (AI)-based data analysis, plays a significant role in increasing investor participation, transparency and operational efficiency of the Islamic capital market. In addition, strategies that focus on investor education, innovation in investment products that comply with sharia principles, and collaboration between stakeholders are proven to support the optimization of sharia stock marketing. The implementation of digital technology in sharia stock marketing can increase the attractiveness of sharia-based investments and expand the market. This research is expected to provide strategic insight for regulators, market players and other stakeholders in optimizing the role of digital technology to strengthen the Islamic capital market in a sustainable manner
Producción Escrita en Español L2: Influencia de la Autoeficacia y el Perfil Lingüístico en la Complejidad Textual
Authors: Godínez López Eva Margarita , Rosas-Mayen Norma 
Published: December 2024

Este estudio examina la relación entre el perfil lingüístico (hablantes de herencia y no hablantes de herencia), la autoeficacia percibida y la complejidad textual en la producción escrita de aprendices de español como segunda lengua en un contexto universitario norteamericano. Con una muestra de 12 participantes, se recopilaron ensayos académicos y datos a través de un cuestionario, analizando la dificultad percibida y las métricas textuales mediante herramientas como TextInspector y Legible.es. Los resultados muestran que la percepción de facilidad influye significativamente en la complejidad textual: los textos percibidos como fáciles presentan menor diversidad léxica y longitud promedio de oraciones, mientras que los textos percibidos como difíciles son más elaborados. Aunque no se encontraron diferencias significativas en las métricas textuales entre hablantes de herencia y no hablantes de herencia, los primeros reportaron mayor facilidad en aspectos temáticos, mientras que los segundos identificaron mayores desafíos en la gramática. Estos hallazgos destacan la importancia de considerar tanto las percepciones subjetivas como las métricas objetivas en el diseño de tareas pedagógicas. Finalmente, se proponen recomendaciones para equilibrar los niveles de dificultad, fortalecer la autoeficacia y atender las necesidades específicas de cada perfil lingüístico.
Sistema de control y monitorización del robot EPSON utilizando realidad aumentada para los estudiantes de la Universidad Técnica de Ambato.
Authors: Illescas Domínguez Britney Melanie , Salazar Logroño Franklin Wilfrido , Machado Merino Gustavo Danilo 
Published: December 2024

Este artículo describe el desarrollo de un sistema didáctico interactivo diseñado para facilitar el aprendizaje del uso del brazo robótico Epson ProSix VT6-A901S en un entorno de realidad virtual (VR). El sistema, implementado en Unity y utilizando ROS (Robot Operating System), permite a los estudiantes manipular y controlar el brazo robótico a través de gafas VR, brindando una experiencia inmersiva y práctica. Unity, por su capacidad para integrar simulaciones interactivas, es la plataforma central donde se desarrolló el entorno virtual, permitiendo la creación de una interfaz intuitiva y accesible. A través de scripts personalizados en Unity, los usuarios pueden controlar en tiempo real los movimientos del robot y recibir retroalimentación visual directa desde el entorno virtual.

El modelo tridimensional del robot fue creado en Blender, lo que posibilita la simulación precisa de sus movimientos y capacidades. Este enfoque educativo busca mejorar la enseñanza de robótica, automatización y control mediante una plataforma accesible y dinámica que combina el mundo virtual y el físico. Los resultados indican que el sistema proporciona una herramienta efectiva para que los estudiantes comprendan de manera intuitiva el funcionamiento y control del robot, fomentando un aprendizaje activo y aplicado en un entorno seguro y controlado.
From Black Gold to Green Goals: Navigating Oil and Gas Sustainability
Authors: Yaghi Racha 
Published: December 2024

The energy transition in the oil and gas sector is a complex but unavoidable journey. While the challenges faced by this sector are significant, the potential for innovation, collaboration, and sustainable growth remains vast. The urgent need for responsible energy policies is crucial to guarantee that energy production aligns with ecological preservation. This paper aims to critically examine the sustainability initiatives implemented by oil and gas companies within their energy policies, assess the international legal frameworks, and analyze national regulations governing the industry. A comprehensive review of existing literature and case studies of industry practices will be conducted to understand the effectiveness of current sustainability efforts. The findings will reveal successful initiatives and areas needing improvement, highlighting the interplay between regulatory frameworks and corporate practices. The study underscores the importance of strategically adopting sustainability measures in the oil and gas sector to mitigate environmental impact while enhancing economic growth. Recommendations will be provided for enhancing stakeholder collaboration and strengthening policy frameworks to support a more sustainable future in the energy landscape.
Effects of defeat and entrapment on suicide risk in university population: the role of rumination and sex
Authors: Silvestre Vidal Inmaculada Nayara , Nieto Marta , Ricarte Jorge , Vizcaíno Alcantud María Dolores , Hallford David , Ros Laura 
Published: December 2024

Background
Suicide is recognized as a significant public health issue, with adolescents/young people being a risk group of concern. Taking the integrated motivational-volitional model as a reference, this study focuses on analyzing the association between defeat and entrapment, on the one hand, and suicide risk, on the other, in a university population without depressive symptoms, while also considering the role of rumination and sex.

Method
The survey study involved a community sample of 650 Spanish university students. A total of 524 students (150 men (Mage = 20.6, SD = 3.7) and 374 women (Mage = 20.4, SD = 3.6)) completed self-report measures of suicide risk, defeat, entrapment, and rumination.

Results
Defeat and entrapment were significantly associated with suicide risk, and higher rumination was both directly and indirectly associated with higher levels of entrapment through the variable of defeat. However, the effect of rumination on entrapment varied by sex.

Conclusion
Despite being a cross-sectional preliminary study, this work identifies important variables in the trajectory of suicidal ideation. Adolescence and young adulthood are a critical stage for intervening to reduce the risk of death by suicide, and this study provides findings that may inform preventive approaches.
A New Frontier of Printed Electronics: Flexible Hybrid Electronics
Authors: Khan Yasser , Thielens Arno , Muin Sifat , Ting Jonathan , Baumbauer Carol , Arias Ana C. 
Published: November 2019

AbstractThe performance and integration density of silicon integrated circuits (ICs) have progressed at an unprecedented pace in the past 60 years. While silicon ICs thrive at low‐power high‐performance computing, creating flexible and large‐area electronics using silicon remains a challenge. On the other hand, flexible and printed electronics use intrinsically flexible materials and printing techniques to manufacture compliant and large‐area electronics. Nonetheless, flexible electronics are not as efficient as silicon ICs for computation and signal communication. Flexible hybrid electronics (FHE) leverages the strengths of these two dissimilar technologies. It uses flexible and printed electronics where flexibility and scalability are required, i.e., for sensing and actuating, and silicon ICs for computation and communication purposes. Combining flexible electronics and silicon ICs yields a very powerful and versatile technology with a vast range of applications. Here, the fundamental building blocks of an FHE system, printed sensors and circuits, thinned silicon ICs, printed antennas, printed energy harvesting and storage modules, and printed displays, are discussed. Emerging application areas of FHE in wearable health, structural health, industrial, environmental, and agricultural sensing are reviewed. Overall, the recent progress, fabrication, application, and challenges, and an outlook, related to FHE are presented.
Pharmacokinetic studies of a novel tubulin inhibitor SK1326 in rat plasma by UPLC–MS/MS
Authors: Ji Young Seok , Kim Tae Kon 
Published: November 2019

AbstractA sensitive method for quantitation of SK1326 in rat plasma has been established using ultra‐performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC–ESI/MS/MS). SK1326 and the internal standard (tramadol) in plasma sample were extracted using acetonitrile. A centrifuged upper layer was then evaporated and reconstituted with a mobile phase of 0.5% formic acid–acetonitrile (35:65, v/v). The reconstituted samples were injected into a C18 reversed‐phase column. Using MS/MS in the multiple reaction monitoring mode, SK1326 and tramadol were detected without severe interference from the rat plasma matrix. SK1326 produced a protonated precursor ion ([M + H]+) at m/z 432.3 and a corresponding product ion at m/z 114.4. The internal standard produced a protonated precursor ion ([M + H]+) at m/z 264.4 and a corresponding product ion at m/z 58.1. Detection of SK1326 in rat plasma by the UPLC–ESI/MS/MS method was accurate and precise with a quantitation limit of 1.0 ng/mL. The validation, reproducibility, stability and recovery of the method were evaluated. The method has been successfully applied to pharmacokinetic studies of SK1326 in rat plasma. The pharmacokinetic parameters of SK1326 were evaluated after intravenous (at a dose of 10 mg/kg) and oral (at a dose of 20 mg/kg) administration of SK1326 in rats. After oral administration (20 mg/kg) of SK1326, the F (fraction absorbed) value was ~77.1%.
Soret and Dufour effects between two rectangular plane walls with heat source/sink
Authors: Ali Aamir , Iqbal F. , Khan Marwat D. N. , Asghar S. , Awais M. 
Published: November 2019

AbstractThis study addresses the thermo‐diffusion and the diffusion‐thermo phenomena in a semi‐infinite absorbent channel whose walls are contracting/expanding, with heat source/sink effects. The governing partial differential equations with suitable boundary conditions are transformed to a system of dimensionless ordinary differential equations. An analytic solution of the problem has been found using a technique called homotopy analysis method (HAM). HAM gives consistently valid answers to the problem over an extensive variety of parameters and also provides better accuracy. To validate the analytical results, a comparison has been presented with a numerical solution calculated by using the parallel shooting method. The effects of dimensionless parameters, that is, deformation parameter, Reynolds number, Soret and Dufour numbers, and heat source/sink parameter on the expressions of velocity, temperature, and concentration profiles are analyzed graphically to understand the physics of the deformable channel. It has been noted that the velocity across the channel is higher for the expanding channel, as compared to that for the contracting channel. Also the Soret and Dufour number increases the temperature of the fluid, and decreases the concentration. The temperature profile has an increasing behavior in the case of heat source, and a decreasing behavior in the case of heat sink.
The Accuracy of Prevalent Vertebral Fracture Detection in Children Using Targeted Case-Finding Approaches
Authors: Ma Jinhui , Siminoski Kerry , Wang Peiyao , Alos Nathalie , Cummings Elizabeth A , Feber Janusz , Halton Jacqueline , Ho Josephine , Houghton Kristin , Lang Bianca , Miettunen Paivi M , Scuccimarri Rosie , Jaremko Jacob L , Koujok Khaldoun , Lentle Brian , Matzinger Mary Ann , Shenouda Nazih , Rauch Frank , Ward Leanne M ,   and the Canadian Steroid-Induced Osteoporosis in the Pediatric Population (STOPP) Consortium
Published: November 2019

ABSTRACT
Due to concerns about cumulative radiation exposure in the pediatric population, it is not standard practice to perform spine radiographs in most conditions that predispose to vertebral fracture (VF). In this study we examined the accuracy of two clinical predictors, back pain and lumbar spine bone mineral density (LS BMD), to derive four case-finding paradigms for detection of prevalent VF (PVF). Subjects were 400 children at risk for PVF (leukemia 186, rheumatic disorders 135, nephrotic syndrome 79). Back pain was assessed by patient report, LS BMD was measured by dual-energy X-ray absorptiometry, and PVF were quantified on spine radiographs using the modified Genant semiquantitative method. Forty-four patients (11.0%) had PVF. Logistic regression analysis between LS BMD and PVF produced an odds ratio (OR) of 1.9 (95% confidence interval [CI], 1.5 to 2.5) per reduction in Z-score unit, an area under the receiver operating characteristic curve of 0.70 (95% CI, 0.60 to 0.79), and an optimal BMD Z-score cutoff of −1.6. Case identification using either low BMD alone (Z-score &lt; −1.6) or back pain alone gave similar results for sensitivity (55%, 52%, respectively), specificity (78%, 81%, respectively), positive predictive value (PPV; 24%, 25%, respectively), and negative predictive value (NPV; 93%, 93%, respectively). The paradigm using low BMD plus back pain produced lower sensitivity (32%), higher specificity (96%), higher PPV (47%), and similar NPV (92%). The approach using low BMD or back pain had the highest sensitivity (75%), lowest specificity (64%), lowest PPV (20%), and highest NPV (95%). All paradigms had increased sensitivities for higher fracture grades. Our results show that BMD and back pain history can be used to identify children with the highest risk of PVF so that radiography can be used judiciously. The specific paradigm to be applied will depend on the expected PVF rate and the clinical approach to the use of radiography. © 2019 American Society for Bone and Mineral Research.