bluuebunny/crossref_metadata_2025_split huggingface dataset:
2,4-SUBSTITUTED QUINAZOLINE AS JAK2 INHIBITOR: DOCKING AND MOLECULAR DYNAMICS STUDY
Authors: BUGGANA SIVA JYOTHI , PATURI MANI CHANDRIKA , VVS RAJENDRA PRASAD 
Published: February 2020

Objective: The involvement of Janus kinase2/signal transducer and activator of transcription (JAK2/STAT3) pathway reported in various solid tumors made authors study the conformational changes of JAK2-3e complex which was previously reported with a moderate percentage of In-vitro JAK2 inhibition.
Methods: In this present study Compound 3e was reported with a moderate percentage of inhibition of JAK2 protein selected for performing molecular docking and molecular dynamics studies to elucidate the conformational changes with JAK2-3e complex. Docking studies were performed using ChemSketch to draw the structure of the compound and optimized/energy minimized using the Ligprep module of Schrodinger suite, employing optimized potentials for liquid simulations (OPLS-2005) force field. Molecular dynamics simulations were performed for 10 ns for complex using TIP4PEW water solvent model and neutralized by adding sodium ions.
Results: Docking studies of Compound 3e which has been reported as one of the effective cytotoxic agents and a moderate percentage of In-vitro JAK2 inhibition among the series, showed H-bond interaction with leucine 855, serine936, aspartine994. Dock score and Ligand binding energy with protein suggested compound 3e has shown-4.049,-66.003 kcal/mol respectively. Molecular dynamics simulations elucidated the mechanistic insight of JAK-2 inhibition. The Root means square deviation (RMSD) pattern of both protein and ligands in the JAK2-3e complex observed to be different over 10 ns simulation. In the JAK2-3e complex, an exponential increase in RMSD of Cα and side-chain amino acids is observed during the first 1-3 ns simulation and is stabilized till 10 ns. During the 10 ns simulation, ligand 3e seems to be stable in the complex with an overall deviation<1 Å, despite a drastic increase between 1-3 ns. The ligand RMSD plot suggests that the ligand 3e remained intact within the binding site of the protein and longer time period simulation may elucidate the binding pattern and fate of ligand 3e.
Conclusion: Results from molecular dynamics simulations elucidated the mechanistic insight of JAK-2 inhibition by 2, 4 disubstituted quinazoline compound that is N’(2-(4-nitrophenyl)quinazoline-4-yl) isonicotinohydrazide) and their binding phenomenon. Molecular docking studies further supported the elucidation of binding patterns of the molecules in the JAK-2 protein environment. Further simulations with a longer time period may provide deeper insights into ligand interactions in the protein environment. It is noteworthy to use compound 3e as a new scaffold for further development of multifunctional compounds.
ASSESSMENT OF MENSTRUAL HEALTH AND ANALGESICS USAGE IN YOUNG AGE WOMEN
Authors: AMEEN ALMOHAMMADI , SUHAIL JUNAID , LOUJAIN SHORBATLI , AMAL AL-SOMALI 
Published: February 2020

Objective: The study focuses on assessing the incidence of menstrual irregularity among young women and the factors for a disturbance with the rationale to assess the use of analgesic drugs during Premenstrual Syndrome (PMS).
Methods: A cross-sectional study was used. A total of 2500 randomly selected young female between the age of 11 and 30 y completed the study questionnaire to assess lifestyle pattern, variations in menstrual pattern, perceived stress, and to capture information about their menstrual cycle and related problems. In addition, the questionnaire assessed the use of analgesics for PMS.
Results: 2481 participants completed the questionnaire. The mean age of participants’ menarche was 12.85±1.432 y. The prevalence of menstrual irregularities was 25.0 % (n=621) and about 8.5% (n=211) of respondents had severe pain that was not relieved by the use of analgesics. On the other hand, 50.9 % (n=1262) reported severe pain that was relieved by analgesics. A total of 1279 (51.6 %) of participants in this study used Over The Counter (OTC) analgesics to relieve PMS.
Conclusion: Dysmenorrhea is the most common complaint among young females in Saudi Arabia. Low Body Mass Index (BMI), sedentary lifestyle, stress and early age of menarche are the most important factors associated with menstrual irregularities. Proper education programs and awareness among young girls about their menstrual health, and the provision of guidance in choosing effective analgesics and treatment options for dysmenorrhea are highly recommended.
POTENSI TRIATOMA SP DALAM PENYEBARAN PENYAKIT TULAR VEKTOR EMERGING DI INDONESIA
Authors: Novita Risqa 
Published: February 2020

The era of globalization allows migration fastly, so we do not have boundary of a country. This led to an increase of the infectious diseases. Indonesia also have an impact on this globalization by highly migration. Indonesia is a tropical country and has diversity of vectors that can transmit various tropical diseases. One of a vector which transmitted vector borne diseases is a bug Triatoma. Triatoma lives near the people’s house and in the bed. One of the species of Triatoma which found in indonesia is Triatoma rubrifasciata which is vector of Chagas disease and Leprosy and can cause allergic reaction of the skin after the bite. Triatoma infection in Southeast Asia, including in Indonesia has not been widely reported. This condition should make us to be alert on the disease emerging or re emerging diseases that can be caused by Triatoma . This article aims to study Triatoma as a vector of emerging and potentially re emerging diseases in Indonesia, which are Chagas, skin allergic reaction after bite and Leprosy. Methods. Literature review by look in google scholar and pubmed, by search using keywords: emerging parasitic, vector borne diseases, Triatoma in Southeast Asia. Inclusion criterias are research articles, laboratory research, case report, and systematic surveillance. Based on the literatures, tracing data that Indonesia has a chance to be the cases of Chagas disease, Skin allergic reaction of Triatoma and Leprosy. It is supposed to made the vigilance on make a early warning system, so our public health coud be achieved highest.
Diario de clase: un día como otro cualquiera en un aula de infantil
Authors: Valenzuela Sánchez Antonia 
Published: February 2020

En este artículo se presenta el diario de una maestra de una Escuela Infantil, a través del cual nos introduciremos en los diferentes momentos de la jornada de un aula de 4 años. Se ha hecho especial hincapié en la asamblea, el método de proyectos, la importancia de la planificación conjunta y la organización espacial, así como del juego y sus modalidades, todo visto desde el prisma del respeto y la inteligencia emocional.
Analisis Perubahan Waktu Pengeringan Terhadap Variasi Tinggi Cerobong
Authors: Syafrun Muhammad 
Published: February 2020

This study aims to find out the efficiency of grain dryers using a chimney and a fan as suction air from the collector into the drying chamber.The research was conducted at the Central of Laboratory Department of Mechanical Engineering Faculty of Engineering, University of Muslim Indonesia, Makassar. A dryer was made from a zinc plate of 0.2 mm as collector by using a hot-air and solar energy as a drying medium. It was expected that this tool can dry grain quickly with evenly distributed drying level or water content. There were five variations of the Chimney : 20 cm, 50 cm, 80 cm, 110 cm and 140 cm with the grain thickness of 7 cm, 5 cm and 3 cm. The data were then analyzed to obtained the efficiency of the dryer. The results reveal that the time required to lower the water content of the harvest grain from 24.6% to 13.6% - 13.85% of milled moisture was 4 hours - 6.5 hours with an efficiency of 34,232 % for grain thicknes 7 cm, 31,480 % for grain thicknes 5 cm and 30,122 for grain thicknes 3 cm at 80 cm chimney height.
Analisis Jarak Gading dan Kekuatan Batas Struktur Kapal Ferry Ro-ro
Authors: Wulandari Amalia Ika 
Published: February 2020

Abstrak
Perkembangan peraturan konstruksi tidak lagi mengatur jarak gading. Sehingga para perancang kapal merencanakan jarak gading yang optimal dengan batasan resiko tekuk pada pelat menurut peraturan klasifikasi, momen batas struktur kapal harus sama dengan atau lebih besar dari 1.2 kali momen lentur vertikal (sagging dan hogging). Momen lentur vertikal dihitung dengan menggunakan formulasi yang telah diberikan oleh BKI. Penelitian ini bertujuan untuk mengetahui kekuatan batas pada struktur kapal ferry Ro-Ro yang membandingkan hasil dari dua metode yaitu Metode Smith dan NLFEA. Ro-Ro adalah kapal yang menangani muatannya dengan cara rolling it on and off di atas single or series ramps. Ramps yang dapat bekerja baik saat di kapal dan dermaga. Pada penelitian ini menunjukkan perbandingan nilai hasil dari metode NLFEA lebih besar daripada metode Smith. Hal ini dikarenakan metode NLFEA dapat menghitung redistribusi beban dan interaksi antara kegagalan lokal dan global secara kompleks sehingga keakuratan hasil perhitungan metode NLFEA lebih baik daripada metode Smith. Semakin jauh jarak gading maka semakin kecil beban batas agar pelat mengalami tekuk.

Kata Kunci: Kapal Ro-Ro, Penampang Melintang, Jarak Gading, Tekuk, Kekuatan Batas

Abstract
The development of construction's regulation is no longer determining the distance of the frame. Hence, the designers make the optimal frame distance plan with the ultimate risk of bending on the plate. According to the classification rules, the structure's ultimate moment must be equal to or greater than 1.2 times vertical bending moment (sagging and hogging). This study aims to determine the ultimate strength on the structure of a Ro-Ro ferry which comparing two methods between the Smith and NLFEA Methods. Ro-Ro is a ship that handles its cargo by rolling it on and off over a single or ramp series. Ramps that can work well on board and dock. The use of ANSYS application that applied NLFEA method in this study shows the comparison of result value of NLFEA method is greater than Smith method. This is because the NLFEA method can calculate load redistribution and the interaction between local and global failures in a complex way so that the accuracy of the NLFEA method is better than the Smith method. The further the ivory distance the smaller the load limit for the plate to buckling.
EVALUACIÓN NEUROPSICOLÓGICA DE LAS FUNCIONES EJECUTIVAS EN PACIENTES CON TRASTORNO MENTAL GRAVE
Authors: Martin Diaz Olga , Daza González Maria Teresa , Santiago Molina Encarnacion , Garrido Fernández Pablo , Ruiz Castañeda Pamela 
Published: February 2020

ResumenLas funciones ejecutivas se refieren a un conjunto de procesos cognitivos de orden superior que nos permiten participar en comportamientos independientes, intencionados y autodirigidos, y son un componente importante de la capacidad de encajar socialmente. Sin embargo, en pacientes con enfermedad mental grave (SMI), en el que las principales limitaciones se observan precisamente en el grado de autonomía e independencia, muy pocos estudios que han explorado sistemáticamente estas funciones. En el presente estudio se administró una batería de tareas neuropsicológicas computarizadas destinadas a evaluar varios componentes de la función ejecutiva (memoria de trabajo, control inhibitorio, flexibilidad cognitiva, planificación y proceso de toma de decisiones), se administró a un grupo de 38 pacientes con SMI y a un grupo de sujetos de control con características sociodemográficas similares. El grupo de pacientes SMI mostró un peor rendimiento en tareas que implican memoria de trabajo, control inhibitorio, flexibilidad cognitiva y planificación; sin embargo, en cuanto al proceso de toma de decisiones en condiciones de incertidumbre,se desempeñaron de manera similar al grupo de sujetos decontrol. El patrón de déficit según los pacientes con SMI sugiere que la mayoría de los componentes ejecutivos que se consideran necesarios para poder responder de forma adaptativa a nuevas situaciones, que están asociadas con la corteza prefrontal dorsolateral y la corteza cingulada anterior, están deterioradas en estos pacientes. Sin embargo, los procesos ejecutivos asociados con la corteza prefrontal ventromedial/orbitofrontal no parecen mostrar el mismo grado de deterioro.
Permenant Downhole Monitoring System PDHMS Reliability
Authors: Sadah Hassan , Kadem Mohammad , Yateem Karam , Dabbous Mohamemd 
Published: February 2020

The demand for permanent downhole monitoring systems (PDHMS's) has been increasing over the last two decades. These systems, along with other real-time and intelligent field technologies, provide real-time data that are crucial to both reservoir and production engineers with reservoir modeling and production strategies.A PDHMS consists of two main parts, which are downhole and surface equipment. Although the installation cost of this equipment might not be significant if installed during initial completion or routine workover, replacing defective downhole equipment is costly as it will require a workover operation. Therefore, it is important to capitalize on all opportunities to retrieve and analyze defective downhole equipment to minimize future malfunction, increase the life expectancy, reduce operational cost, and enhance efficiency.This paper studies several downhole gauge challenges to find out their root causes. This will help in enhancing future designs and reducing the number of downhole gauge replacements. These gauges were retrieved during scheduled workover operations on several wells. They were retrieved and sent to their manufacturers for Dismantle Inspection Failure Analysis (DIFA). The root causes were identified and the recommendations were implemented in all newer models.In many cases, the issue was caused by only one component, which was either downhole gauge malfunctioning or port blockage of the gauge mandrel. The component may vary depending on the gauge manufacturer and model, with the most common causes being the Y-block/Y-splitter, debris and non-properly swaged ferrules.The findings have been utilized by PDHMS manufacturers to amend and enhance their next generations. Taking advantage of as many opportunities as possible to retrieve and study failed equipment will assist oil and service companies to work together for developing more reliable models that can extend their run life even in harsh downhole environments.
Unlocking the Production Potential of Brown Fields through Gas Lift Optimization GLO
Authors: Hammadi Boubaker , Agoudjil Karim , Fahem Abdelhafid , Tadjine Fateh , Moussa Benabdellah Hamza , Makhloufi Abdelhamid , Djebrouni Abdelghani , Bouchikhi Brahim , Younsi Toufik 
Published: February 2020

As a Brown Field, located in North Africa. Approximately 95% of Zarzaitine field wells are utilizing Gas Lift as an artificial lift method. The field has a challenging situation to optimize its Oil production; A detailed understanding of the production sys tem thermohydraulic, facility design and the amount of gas injection will ultimately have a major effect on production target. For this purpose, modeling the entire production system was necessary to properly account for the interdependency of wells and surface equipment and determine the system deliverability as a whole by optimizing Gas Lift injection.
This paper presents an approach which was introduced for the first time in this field to ensure gas is used efficiently using a multiphase flow simulator for wells and pipelines to model the entire field Production Network in addition to the Oil producing wells including Gas lift mandrels. The model includes 112 Gas Lift wells with a detailed Gas Lift valves system currently on production, each one has been matched against the latest valid well test, Seven Separation Centers, Production gathering pipelines, Production gathering Center and Gas Lift Injection Center. The study has been executed in three major phases: Well Modeling & Calibration, Network Modeling and Gas Lift Optimization.
Total Oil production rate has been defined as an objective function during the optimization phase where the total Injected Gas Lift rate for the entire network and for each individual well have been defined as varying parameters; By having a network model calibrated against field data representing the operational conditions of the asset, performing Gas Lift Optimization was the natural next step. Subsequently, by simulating the production system with different Gas Lift Optimization scenarios to maximize Oil production rate under specific surface facilities constraints using the Production Network Model, a better insight of how gas injection rate affects the total production and an understanding of whether a smarter allocation of the current available gas is possible in comparison to the different scenarios has been accomplished. As a result of this Optimization by applying some local and global constraints a 10% Oil production increase has been achieved.
This practice has been shown to be successful as predictive technique in a variety of ways specially for such brown fields with more than 60 years of production history. As a next step, to properly manage the real potential of Brown fields, a full field Integrated Asset Model could be created to capture the interaction between the surface and the sub-surface. This model will account for the complex interactions between reservoir, wells and pipelines.
Огурец на юге: многообразие технологий и гибридов
Authors: Timoshenko I.V. , Ognev V.V. 
Published: February 2020

В последние годы в производстве огурца получили распространение как весенние теплицы, так и зимние с регулируемым микроклиматом. В статье приведены особенности формировки и основные технологии выращивания огурца в защищенном и открытом грунте, разнообразие сортимента культуры огурца.In recent years, cucumber production has become widespread, as spring greenhouses, and winter with a regulated microclimate. This article describes the features of the formation and the main technologies for growing cucumber in a protected and open ground, the variety of the cucumber culture assortment.
Обеззараживание семян капусты от сосудистого бактериоза
Authors: Orynbayev A.T. , Dzhalilov F.S. 
Published: February 2020

Приведены данные двухлетнего исследования по поиску эффективных препаратов для обеззараживания семян капусты от сосудистого бактериоза. Наилучший результат был получен при предпосевной обработке 0,15%-ной надуксусной кислотой. При этом биологическая эффективность составляла 94,1–97,6%, что значительно превышало соответствующий показатель в эталонном варианте – Фитолавин, ВРК, 0,2% (69,0–72,0%). Показано, что заблаговременная обработка семян НУК (за 550 суток до посева) не оказывала достоверного влияния на их лабораторную всхожесть.Presented data are the result of a two-year study aimed at identifying effective preparations for the disinfection of cabbage seeds from black rot. The best result was obtained by presowing treatment with 0.15% peracetic acid. In this case, the biological efficiency was 94.1–97.6%, which significantly exceeded the corresponding indicator in the reference variant – Phytolavin, VRK, 0.2% (69.0–72.0%). The study has not revealed any significant effect of advance treatment of seeds with peracetic acid (550 days before sowing) on their laboratory germination.
Защита столовой свеклы от церкоспороза в условиях Приморского края
Authors: Vanyushkina I.A. , Kushnareva N.P. , Mikheev Y.G. , Leunov V.I. 
Published: February 2020

Приведены результаты испытания фунгицидов Аканто Плюс, Рекс Дуо и Скор против церкоспороза столовой свеклы. Показана их биологическая эффективность (до 98,4%) и способность обеспечивать повышение урожая стандартной продукции (до 41,2%).The results of the test of fungicides Acanto Plus, Rex Duo and Scor against cercosporosis. Their biological effectiveness (up to 98.4%) and the ability to raise a crop of standard products (up to 41.2%).
Гибриды перца сладкого для товарного производства
Authors: Ognev V.V. , Chernova T.V. , Kostenko A.N. , Poltavskiy N.A. 
Published: February 2020

Представлен обзор селекционной работы по культуре перца сладкого в Агрохолдинге «Поиск». Выделены актуальные направления исследований в селекции перца на гетерозис. Представлены лучшие гибриды для различных направлений использования в товарном производстве.Main directions of breeding and results of breeding work by Poisk Agro Holding in sweet pepper are presented. Hybrids identified for intensive growing in open ground and springhouse, for various uses.
Государственно-частное партнерство – самый эффективный путь развития отечественной селекции овощных культур
Authors: Klimenko N.N. 
Published: February 2020

Проанализированы предпосылки и причины небольшой доли российских сортов и гибридов на отечественном рынке: неудовлетворительного состояния селекционной работы и малого практического выхода в виде конкретного рыночного селекционного продукта в бюджетных научных учреждениях. Основная причина – отсутствие реальной связи между ними и запросами рынка. Эффективно восстановить эту связь может системное партнерство между государственными научными учреждениями и частными селекционно-семеноводческими компаниями. Изложен зарубежный опыт формирования конкурентоспособной селекции, работающей именно по этому принципу.The background and causes of a small part of Russian cultivars and hybrids in the domestic market is analysed: the poor state of breeding work and small practical output as concrete market breeding product in the budgetary scientific institutions. The main reason of it is the lack of real communication between them and the demands of the market. Effective way to restore the connection is a systemic partnerships between state research institutions and private seed companies. Foreign experience of forming competitive selection operating on this principle is presented.
Инновационные технологии в производстве рассады цветочных культур
Authors: Korchagin A.V. 
Published: February 2020

Рассмотрены различные аспекты производства рассады цветочных культур, позволяющие достигнуть высокого качества продукции: правильный выбор посевного материала, механизация производства, досветка растений и применение регуляторов роста, использование готовых сеянцев.Various aspects of the production of flower seedlings to achieve high product quality are considered: the right choice of seeds, mechanization of growing, supplementary lighting of the plants and the application of growth regulators, the use of ready-made seedlings.
Оценка образцов картофеля
Authors: Lapshinov N.A. , Gantimurova А.N. , Kulikova V.I. , Кhodayevа V.P. 
Published: February 2020

В 2016–2017 годах в коллекционном питомнике изучали 170 образцов картофеля мировой коллекции ВИР и других НИУ с целью выделения источников ценных признаков. По комплексу хозяйственно ценных признаков выделилось 7 сортов. Сорта и гибриды, выделившиеся по отдельным признакам и комплексу признаков, используют в селекционной работе как исходный материал для создания новых сортов картофеля.In 2016–2017 years the collection nursery studied 170 samples of potatoes of world collection of VIR and other research enterprises to select sources of valuable traits. The complex of economically valuable traits stood out 7 cultivars. Cultivars and hybrids released for individual signs and the complex signs used in breeding as source material for creating new potato cultivars.