bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential aromatase inhibitors and antiestrogen agents based on stilbene and stilbazole derivatives
Authors: Adamchyk S. V. , Michal’chuk A. L. 
Published: March 2020

Abstract. Widely used forms of endocrine therapy for women with hormone-dependent breast cancer include blocking the biosynthesis of estrogens through using inhibitors of cytochrome P450 19A1 (aromatase). A series of new stilbene and stilbazole based aromatase inhibitors on are prepared. Z-isomers of 4-(2-(pyridin-4-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl) benzonitrile, 4-(2-(pyridin-3-yl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-fluorophenyl)-1-(1H-1,2,4-triazol1-yl)vinyl)benzonitrile, 4-(2-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile, 4-(2-(4-bromophenyl)-1-(1H-1,2,4triazol-1-yl)vinyl)benzonitrile, 4-(2-(3,4-dimethoxyphenyl)-1-(1H-1,2,4-triazol-1-yl)vinyl)benzonitrile were prepared by condensation of 4-((1H-1,2,4-triazol-1-yl)methyl)benzonitrile and corresponding aldehyde in presence of strong base followed by dehydration of obtained alcohols. Isomerization to corresponded E-isomers was carried out in the presence of UV light.
Formation of the “setting” level of body temperature regulation during endotoxin fever
Authors: Vismont F. I. , Vismont A. F. 
Published: March 2020

The experiments on rats and rabbits using modern physiological, biochemical research methods and the pharmacological approach established that in the body, the action of bacterial endotoxin, accompanied by fever, leads to a significant decrease in blood plasma and in CSF of the arginine content. In rabbits after 30 min intravenous administration of carbon-labeled arginine hydrochloride (25 μCi/kg) at the endotoxin fever peak (after the 60 min injection of endotoxine E. coli), the radioactivity level in the blood plasma decreases and significantly increases in the cerebrospinal fluid and the hypothalamus tissue. It was revealed that although the content and speed of norepinephrine turnover in the hypothalamus after the introduction of L-arginine hydrochloride (100 μg) into the ventricles of the rats does not change in comparison with control animals, however, the chemoreactive properties of the thermoregulatory structures of the brain have changed, which manifests itself in the change in the expression and duration of thermoregulatory effects of the central action of norepinephrine and acetylcholine. It was established that the administration of L-arginine hydrochloride into the brain ventricles at a dose of 100 μg per animal or in the blood flow at a dose of 20 mg/kg caused the pronounced antipyretic effect. It was found that L-arginine hydrochloride (100 μg), after it has been introduced into the ventricles of the brain, increases the impulse activity of heat-sensitive neurons of the medial preoptic region of the anterior hypothalamus in rabbits due to a brain temperature growth when the animal’s body is overheated. Apparently, CSF arginine can be considered as an important factor in the changes in the excitability thresholds of cold and heat-sensitive neurons in the hypothalamus and in the formation of the “setpoint” of body temperature regulation during endotoxin fever.
Myocardial bridges and obstructive coronary atherosclerosis
Authors: Kabak S. L. , Melnichenko Yu. M. , Gordionok D. M. , Kalenchic T. I. , Haidzel I. K. , Yudina O. A. 
Published: March 2020

The myocardial bridge (MB) is a congenital anomaly, in which a segment of a coronary artery courses through the myocardium. The aim of the study was to establish the location of myocardial bridges and the severity of atherosclerotic lesions of the coronary arteries in patients with coronary heart disease symptoms and in individuals who are the potential heart donors for transplantation. The data of the multislice computed tomography coronary angiography of the patients of the Republican Scientific and Practical Centre “Cardiology” from 2016 to 2018 were included in this study. 324 hearts of the deceased donors, which had not been used for orthotopic transplantation, were studied. According to the autopsy and the CT coronary angiography, the myocardial bridges were localized mainly in the left anterior descending artery of the left coronary artery (LCA). In 7.4 % of cases, MBs were found in a distal portion of the intermediate branch of LCA, in the left postero-lateral branch, in the right coronary artery, in the first diagonal artery, as well as along the obtuse marginal artery and the left circumflex coronary artery. In 36 % of cases, the identified bridges were considered as hemodynamically significant with regard to the length of the tunneled artery segment and its depth. Microscopic examination of the tunneled fragments of the coronary arteries in 4.9 % of cases showed the initial signs of damage of the vessel wall in the form of fibromuscular dysplasia and lipidosis. According to the CT coronary angiography results, no causal relationship has been established between the presence of MBs and atherosclerosis in the subepicardial segments of the coronary arteries.
Experimental justification of the method of mesenchymal stem cell autotransplantation for regeneration of the femoral head bone tissue
Authors: Murzich A. E. , Pashkevich L. A. , Zhernasechanka H. A. 
Published: March 2020

The results of experimental justification of a new method for restoring the femoral head bone tissue with the use of mesenchymal stem cells (MSCs) are presented. Surgical interventions were performed on 5 dogs, including the bone marrow exfusion, the obtaining of MSCs and their subsequent osteogenic differentiation, the selection of a carrier for MSCs, the creation of femoral head defects, and the implantation of a cellular product into a bone defect. Experimental animals were observed and cared after operations, and removed from the experiment, as well as the biological material was taken. The histological results of the femoral head micropreparations of dogs confirm the formation of the mature bone tissue of compact structure with osteoblasts at the site of MSCs injection. In the control group of the experimental samples (without MSCs), the The obtained experimental material will allow us to develop a method for autologous transplantation of MSCs for regenerative restoration of bone tissue damage in the adult’s femoral head osteonecrosis, which will find use in the practical healthcare system.
Antioxidant capacity profile of dewandaru leaf (extract eugenia uniflora l.): part of usadha Bali
Authors: Santoso Puguh , Dewi Ni Luh Kade Arman Anita , Adrianta Agus 
Published: March 2020

Bali has around 50,000 usadha palm oil which is a source of untreated herbal medicine. One of the plants that have the potential as an antioxidant and is traditionally used by the community is Dewandaru (Eugenia uniflora L.) plant. Dewandaru containing tannins, flavonoids, and anthocyanins. Dewandaru plants have antibacterial activity, antioxidants, and antidotes to free radicals. Making extract with six different solvents, among them methanol, ethyl acetate, n-butanol, chloroform, and n-hexane. The measurements were taken of the reduction of free radical activity by observing the absorbance at the maximum wavelength with a UV-Vis spectrophotometer alternately on the six samples. Secondary metabolites contained in Dewandaru leaves, namely flavonoids, tannins, and quinones. The value obtained is IC50 methanol extract 5,857 ppm; n-butanol extract 8,893 ppm; ethyl acetate extract 15,203 ppm; n-hexane extract 162.7315 ppm; and chloroform extract 75,873 ppm. Methanol extract, n-butanol, and ethyl acetate have very strong antioxidant activity because <50 ppm; n-hexane extract has weak antioxidant activity (ranging from 150-200 ppm), and chloroform extract has strong antioxidant activity (ranging from 50-100 ppm). Major conclusions: Dewandaru leaves has the potential as a natural antioxidant in the treatment section of Usadha Bali.
On the Comparative Semantics of Russian Adverbs with the Prefix <i>po-</i> and Their Culturally Significant Meanings
Authors: Devyatova N. M. 
Published: March 2020

This article describes the use of adverbs with the prefix po- for the purposes of comparison in the Russian language. The comparative semantics and culturally significant meanings of the adverbs po-chelovecheski and po-lyudski are provided. An analysis of language material is carried out using the methods of structural semantics. Features of the adverbs are revealed in their comparison with the clauses «kak chelovek, kak lyudi». The synonymous relations of the language units, their similarities and differences are considered. This article shows that the field of synonymy is composed of sentences reflecting the human behavioural sphere, while the differences are related to ideas concerned with ethical standards.
Identifikasi Kesalahan Siswa SMA dalam Membuat Pemodelan Matematika dan Penyebabnya
Authors: Bahir Rosdati Amira , Mampouw Helti Lygia 
Published: March 2020

Abstract
This research aims to describe senior high school students’ error in creating mathematical modeling and the factors which cause to. The subjects consisted of 9 students from SMA Negeri 1 Tuntang who were obtained by snowball technique. The data obtained from the results of observations and in-depth interviews with the subjects. The results showed that students ' error in creating mathematical modeling are students cannot identify the variables on the problem, so they didn’t have the variables to be model, students didn’t make assumptions about the models that will be formulated into equations, and also the students had an error in formulating and resolving equations. The error is caused by internal and external factors. The internal factors are lack of practice in doing an exercise about the story questions, not knowing about mathematical modeling and the importance of mathematical modeling to solve the story question, using reasoning or their own instincts to solve word problems; and external factors namely the level of difficulty of the given questions and the lack of learning infrastructure such as sourcebooks or other sources.
Keyword: errors, causes, mathematical modeling.

Abstrak
Penelitian deskriptif kualitatif ini bertujuan untuk mendeskripsikan kesalahan siswa SMA dalam membuat pemodelan matematika dan faktor-faktor yang menyebabkan terjadinya kesalahan tersebut. Subjek terdiri 9 siswa SMA Negeri 1 Tuntang yang diperoleh dengan teknik snowball. Data diperoleh dari hasil observasi dan wawancara terhadap subjek penelitian. Hasil penelitian menunjukkan bahwa kesalahan siswa dalam membuat pemodelan matematika yaitu siswa tidak dapat mengidentifikasi variabel-variabel pada masalah sehingga tidak memiliki jabaran variabel untuk menjadi model, siswa tidak membuat asumsi tentang model yang akan diformulasikan ke dalam persamaan, serta siswa salah dalam memformulasikan dan menyelesaikan persamaan. Kesalahan tersebut disebabkan oleh faktor internal yakni siswa tidak mengetahui tentang pemodelan matematika dan pentingnya pemodelan matematika untuk menyelesaikan soal cerita, kurang latihan mengerjakan soal-soal cerita, menggunakan cara nalar atau insting sendiri dalam menyelesaikan soal cerita dan faktor eksternal yakni tingkat kesulitan soal yang diberikan dan kurangnya sarana prasarana seperti buku sumber ataupun sumber lainnya.
Kata kunci: kesalahan, penyebab, pemodelan matematika.
Praktikalitas bahan ajar matematika terintegrasi nilai islam menggunakan pendekatan saintifik untuk pengembangan karakter peserta didik
Authors: Nurhamdiah Nurhamdiah , Maimunah Maimunah , Roza Yenita 
Published: March 2020

Pengembangan karakter peserta didik menjadi fokus utama dalam dunia pendidikan. Hal ini didasarkan pada fakta tentang menurunnya karakter anak bangsa. Penelitian ini bertujuan untuk menghasilkan bahan ajar matematika terintegrasi nilai Islam melalui pendekatan saintifik yang valid dan praktis untuk mengembangkan karakter peserta didik pada materi himpunan. Jenis penelitian yang digunakan adalah penelitian pengembangan menggunakan model ADDIE. Instrumen dalam penelitian ini adalah lembar praktikalitas yaitu angket respon peserta didik dan lembar pengamatan guru. Praktikalitas bahan ajar pada ujicoba lapangan adalah 92,60% dan hasil pengamatan guru dengan rata-rata 96,59%. Dapat disimpulkan bahwa bahan ajar matematika terintegrasi nilai islam menggunakan pendekatan saintifik yang dikembangkan praktis untuk mengembangkan karakter peserta didik kelas VII SMP/MTs.
Analisis Kesalahan Siswa Kesalahan VIII SMP Di Kabupaten Bandung Barat Dalam Menyelesaikan Soal Cerita Pada Materi Perbandingan Ditinjau Dari Gender
Authors: Agnesti Yuni , Amelia Risma 
Published: March 2020

enelitian dilakukan di SMP Pasundan Rongga pada bulan November 2019. Tujuan dari penelitian adalah untuk mengetahui bentuk kesalahan yang dilakukan siswa kelas VIII A dalam menyelesaikan soal cerita. Analisis data yang digunakan mengacu pada analisis kesalahan pada langkah-langkah mengerjakan soal, apakah siswa bisa menyelesaikan dengan tepat, bisa menyelesaikan sesuai dengan intruksi soal yang diminta, dan apakah siswa bisa menyelesaikan soal dengan pemodelan matematikanya. Subjek penelitian adalah siswa kelas VIII A. Pemilihan sampel didasarkan pada siswa laki-laki dan perempuan. Berdasarkan penelitian, terdapat beberapa bentuk kesalahan yang dilakukan, diantaranya kesalahan siswa laki-laki pada soal nomor 1 sebanyak 85,56%, nomor 2 sebanyak 91,67%, nomor 3 sebanyak 88,67%. Sedangkan Kesalahan siswa perempuan pada soal nomor 1 sebanyak 55,56%, nomor 2 sebanyak 45,83%, nomor 3 sebanyak 50%. Selanjutnya diperoleh kesimpulan, bahwa siswa laki-laki memiliki tingkat kesalahan yang tinggi dibanding siswa perempuan. Karena pada saat diwawancara juga mengatakan bahwa di dalam soal cerita itu rendah dalam menguasai soal dan perhitungan , kurang memahami apa makna dari soal dan apa yang harus dicari dari soal-soal tersebut
Evaluation of Assamese buffaloes considering important economic traits under field conditions in their home tracts
Authors: Islam Shafiqul , Alam Safeer , Kaur Gurjeet , Gogai Amulya 
Published: March 2020

The Assamese buffaloes are being reared by the farmers/breeders for milk, meat and for draught purposes. These buffaloes are known for higher fat contents in their milk (8.5 percent on an average) and are famous in the market with a great demand and are known as “Khuti milk”. They are good source of livelihood for breeders and the graziers both in its breeding tract and have attracted researchers to consider the study of some important economic traits under field conditions. The present study was organized and considered the data on a total of 324 Assamese buffaloes distributed over three districts namely Kamrup, Nagaon and Darrang in Assam covering 35 khutis (open herds) during the year 2015-16 eighteen months. The lactation milk yield of Assamese buffalo was observed as 448.38±1.67 kg with a lactation length of 237.06±0.74 days and the peak yield and days to attain were measured as 3.41±0.02 kg and 54.16±0.19 days respectively. The reproduction traits like age at first calving, gestation period, service period and inter-calving period were considered for the study based on the breeders’ interview using pre-structured formats. The age at first calving was recorded as 52.28±0.81 months, the gestation period was observed as 323.10±0.68 days with an inter-calving period of 465.70±1.67 day. The service period and the dry period for these buffalo was 171.34±0.82 and 252.84±1.47 days respectively. The production and reproduction performance of Assamese buffaloes need special attention to be addressed for further improvements to help a large size of population of Assam, who are entirely depending for their livelihood on these valuable AnGR (buffaloes) of Assam.
Effect of intra row spacing, dates of haulm cutting and fertilizer dose on disease free quality seed tuber production of potato (Solanum tuberosum L.) under new Alluvial Zone of West Bengal
Authors: Mandal Manoj , Das Sanjib Kumar 
Published: March 2020

Potato (Solanum tuberosum L.) is the most popular tuber crop in West Bengal, India. Seed tuber is the single most important factor in potato cultivation and if the seed is not of good quality, then optimum production could not be achieved. Unavailability of good quality seed, high price and untimely supply of seed at the village level are the main limiting factors in potato production. Field experiments were conducted during rabi season of 2017-18 and 2018-19 at Bidhan Chandra Krishi Viswavidyalaya, Kalyani, West Bengal to determine the effects of intra row spacing, dates of haulm cutting and fertilizer dose on disease free quality seed grade tuber production of potato. The experiment was laid out in a split split plot design with three replications having twelve treatment combinations. The results revealed that with the decrease in intra row spacing from 20cm to 15cm seed grade size (< 75g) tuber yield and numbers and total tuber numbers were significantly increased but marketable grade (> 75 g) tuber yield and numbers were significantly reduced. Haulm cutting at 65 DAP increased the seed grade size tuber yield and numbers over 75 DAP. With the decrease in fertility levels from 100% RDF of NPK to 50% RDF of NPK the seed grade tuber production and number were significantly increased at 5% level of significance. Disease incidence and intensity of Phoma leaf spot decreased and early blight increased with decreasing doses of fertilizers. No viral disease was observed. Dehaulming at 65 DAP was found safer so far as infestation and chances of viral disease transmission by the sucking pests were concerned. From the present study it may be concluded that, for quality seed tuber production of potato and to get highest net return under New Alluvial Zone of West Bengal, use of 50cm X 15cm spacing along with haulm cutting at 65 DAP, when planting is done on first week of November and grown with 50% RDF of NPK was found best.
A study on landuse and landcover classification using microwave data in Joida taluk of Uttara Kannada district, Karnataka
Authors: Koppad Arjun G. , Syeda Sarfin  , Das Anup Kumar 
Published: March 2020

The study has been conducted for land use and land cover classification by using SAR data. The study included examining of ALOS 2 PALSAR L- band quad pol (HH, HV, VH and VV) SAR data for LULC classification. The SAR data was pre-processed first which included multilook, radiometric calibration, geometric correction, speckle filtering, SAR Polarimetry and decomposition. For land use land cover classification of ALOS-2-PALSAR data sets, the supervised Random forest classifier was used. Training samples were selected with the help of ground truth data. The area was classified under 7 different classes such as dense forest, moderate dense forest, scrub/sparse forest, plantation, agriculture, water body, and settlements. Among them the highest area was covered by dense forest (108647ha) followed by horticulture plantation (57822 ha) and scrub/Sparse forest (49238 ha) and lowest area was covered by moderate dense forest (11589 ha). Accuracy assessment was performed after classification. The overall accuracy of SAR data was 80.36% and Kappa Coefficient was 0.76. Based on SAR backscatter reflectance such as single, double, and volumetric scattering mechanism different land use classes were identified.
An overview on problems and prospects of transplanted maize with special reference to India
Authors: Sardar Somanth , Patra Manasi , Mandal Bappa , Patra B. C. 
Published: March 2020

Transplanting is the technique of moving of a plant from one location to another. This strategy is commonly practiced to establish crops when conditions are less favourable for direct seeding. Birds and squirrels damage to seedlings of maize is a serious problem resulting in poor crop stand and low yield. Delayed germination and plant growth receives a major setback due to late sowing of maize which reduces grain yield; however, reduction of yield can be compensated by transplantation technique. Transplanting of maize is a strategy that can be used to achieve optimum plant densities, better crop stand and obviously to get optimum yield. It reduces the nutrient requirement and also shortens the growth period of crop that helps farmers to harvest a third crop in intensive cropping system. Transplanted crop produces about 15.44% higher grain yield and can be harvested 10-12 days earlier that of direct seeding crop, so, late maturity high yielding cultivars can be fitted in to available growing season. Though, there are several advantages of transplanted maize, it is not popular in India due to lack of awareness, lacking in proper rational scientific technology and very little information about age of seedling and optimum dose of nutrient. Farmers can be benefitted if proper technology regarding age of seedling, process of transplanting and other cultivation techniques of raising transplanted maize is supplied to them.
Assessment of lead toxicity on locomotion and growth in a nematode Caenorhabditis elegans
Authors: Tiwari Shashank Shekhar , Tambo Francis , Agarwal Rakhi 
Published: March 2020

Due to anthropogenic activities and natural abundance, lead exposure is a common phenomenon. Neurotoxic and genotoxic effects of lead are widely known. Recent studies have suggested that lead exposure can affect young generation and transfer to the progeny thus posing a great threat for future generation. The present study was focused on lead toxicity in terms of locomotion and growth of Caenorhabditis elegans (N2 wild type) at three sub-lethal doses (3µM, 15 µM and 30 µM) of Pb (NO3)2 for 24 hours (sub-chronic exposure). Caenorhabditis elegans is a nematode with an established eco- toxicity marker model organism, due to its short life cycle and ease to monitor. After lead exposure, significant toxic manifestations were observed in locomotion of the nematode in terms of omega bends (+350% for 30 µM exposure dose, p<0.001), reversals (-26.98%, -49% and -66.35% for 3 µM, 15 µM and 30 µM exposure doses respectively, p<0.001), turn counts (-38.66%, -62.61% and -81.93% for 3 µM, 15 µM and 30 µM exposure doses respectively, p<0.001 ) and peristaltic speed alterations (+97.83%, +225.92% and +454.63% for 3 µM, 15 µM and 30 µM exposure doses respectively, p<0.001). Successive reduction in the body length at lower doses shows remarkable toxic alterations in nematodes. The obtained data may be useful to extrapolate the effects of lead exposure on humans, as many of the similar pathways and cellular processes affected by Pb in humans are also present in C. elegans.
Enhancing Students' English Speaking Skills through Web-Based Teaching
Authors: Suryana Irfan , Hidantikarnillah Vicky , Ikmi Nur Oktavianti  
Published: March 2020

Teachers play a very important role in the teaching and learning process. They should utilize effective strategies that are included in classroom management. In this digital era, the teachers should adjust their methods in delivering or explaining the materials for the students. One of the technology is the web. The aim of this study is to investigate the teacher’s perceptions of using the web to enhance students’ English speaking skills. This study was under phenomenological qualitative research and characterized by an interdisciplinary approach, especially education and technology. The direct personal interview was utilized to obtain the information from the teacher. The survey encompasses twelve questions that become different categories and was done in eight grades of class B in SMP Negeri 3 Pleret. The results showed that teaching speaking using the web can effectively enhance the students’ English speaking skills and the students give positive reactions regarding this method.