bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of trauma-focused cognitive behavior therapy on depression and the quality of life of the elderly in Indonesia
Authors: Efendi Ferry , Indarwati Retno , Aurizki Gading Ekapuja 
Published: June 2020

Purpose
This study aimed to analyze the effect of Trauma-Focused Cognitive Behavior Therapy (TF-CBT) on the depression level and quality of life of the elderly in an earthquake-affected district of North Lombok Regency, Indonesia.

Design/methodology/approach
A Randomized Controlled Trial (RCT) with a population of two elderly groups living in an earthquake-affected district was used in this study. The intervention comprised giving TF-CBT. There were three research instruments applied to determine the variables, namely, the Clinician-Administered PTSD Scale (CAPS-5), the Geriatric Depression Scale 15 (GDS 15) and the World Health Organization Quality of Life-BREF (WHOQOL-BREF). All instruments were adopted and translated using back translation to Bahasa Indonesia, which is appropriate at the suggestion of the WHO. To investigate the effect of the intervention, we used hierarchical linear models (HLM) with intent-to-treat analysis. The patent parameter effect was tested using the Wald test (t-test) with a confidence Interval of 95 per cent.

Findings
The final analysis applied CAPS-5 and showed that there was a decrease in the PTSD of the respondents, which was down to only 8 (17.8 per cent) in the post-test. The same situation happened for the depression variable (2.8 per cent) after it was assessed using GDS-15C. The Quality of life (WHOQoL-BREF) variable was divided into Physical (50.7), Psychological (57.1), Social (53.6) and Environmental (45.7). These components show there to be a significant result in terms of improving the quality of life of the elderly victims of the earthquake. The finding highlights that applying TF-CBT in the elderly population can significantly drop post-traumatic stress disorder and depression level and enhanced quality of life.

Social implications
The intervention decreased the depression level and improved the quality of life of the elderly as found in the six- week follow-up. Longer training and integration with the structured local wisdom could be necessary to better address the mental health of the elderly affected by the earthquake. Moreover, strengthening the role of the family as the primary caregiver is required to improve the outcome.

Originality/value
This is the first study that has attempted to use TF-CBT as a method of treatment for the elderly to decrease their depression and to increase quality of life among the Indonesian elderly who have experienced an earthquake. This paper provides knowledge on the effectiveness of TF-CBT that can be used by therapists to treat depression problems suffered by the elderly in a post-disaster area.
Changes in older adults’ impairment, activity, participation and wellbeing as measured by the AusTOMs following participation in a Transition Care Program
Authors: Smith Haley N. , Fields Sally M. 
Published: June 2020

AbstractIntroductionMaintaining a continuum of care is vital to ensure adequate health among older adults, particularly during periods of care transitions, when they are vulnerable and at risk of poor health outcomes. The Transition Care Program in Australia is designed to support older adults following the conclusion of a hospital episode. Using the Australian Therapy Outcome Measures for Occupational Therapy (AusTOMs‐OT), this study aimed to understand how the Transition Care Program impacts an older adult’s occupational performance during care transitions.MethodsData were collected as a part of usual occupational therapy care from March 2016 to August 2017 from clients admitted to a Gold Coast Health Transition Care Program. Data from 110 clients were analysed on 5 AusTOMs‐OT scales: functional walking and mobility, upper limb use, self care, domestic life—home, and community life/recreation/leisure/play. Change data from these scales were analysed using the Wilcoxon Signed Ranks Test.ResultsClients in the Transition Care Program experienced statistically and clinically significant improvements in all AusTOMs‐OT scales analysed as well as in each domain of impairment, activity limitation, participation restriction and distress/wellbeing.ConclusionThese results are meaningful for clients, occupational therapists and Australian Transition Care Programs. Clients demonstrated progress towards their goals, indicating maintenance or improvements in their occupational performance, confirming for occupational therapists that the provision of services is promoting goal achievement and leading to improved occupational performance. The study also highlighted the benefits for the use of outcome measures such as the AusTOMs‐OT to quantify and validate client change.
Phenotypic heterogeneity as key factor for growth and survival under oligotrophic conditions
Authors: Kundu Kankana , Weber Nina , Griebler Christian , Elsner Martin 
Published: June 2020

SummaryProductivity‐poor oligotrophic environments are plentiful on earth. Yet it is not well understood how organisms maintain population sizes under these extreme conditions. Most scenarios consider the adaptation of a single microorganism (isogenic) at the cellular level, which increases their fitness in such an environment. However, in oligotrophic environments, the adaptation of microorganisms at population level – that is, the ability of living cells to differentiate into subtypes with specialized attributes leading to the coexistence of different phenotypes in isogenic populations – remains a little‐explored area of microbiology research. In this study, we performed experiments to demonstrate that an isogenic population differentiated to two subpopulations under low energy‐flux in chemostats. Fluorescence cytometry and turnover rates revealed that these subpopulations differ in their nucleic acid content and metabolic activity. A mechanistic modelling framework for the dynamic adaptation of microorganisms with the consideration of their ability to switch between different phenotypes was experimentally calibrated and validated. Simulation of hypothetical scenarios suggests that responsive diversification upon a change in energy availability offers a competitive advantage over homogenous adaptation for maintaining viability and metabolic activity with time.
An Evaluation of Differentially Spliced Genes as Markers of Sex for Forensic Entomology,,
Authors: Jonika Michelle M. , Hjelmen Carl E. , Faris Ashleigh M. , McGuane Alexander S. , Tarone Aaron M. 
Published: June 2020

AbstractBlow flies (Calliphoridae) are important medically and economically and are commonly used in forensics as temporal markers in death investigations. While phenotypic traits in adult flies can be sexually dimorphic, sex identification in immatures is difficult. Consequently, little is known about how sex may result in developmental disparities among sexes even though there are indications that they may be important in some instances. Since genetic mechanisms for sex are well studied in model flies and species of agricultural and medical importance, we exploit the sex‐specifically spliced genes transformer (tra) and doublesex (dsx) in the sex determination pathway to optimize a sex identification assay for immatures. Using known primer sets for tra and with a novel one for dsx, we develop PCR assays for identifying sex in four forensically relevant Calliphoridae species: Lucilia sericata (Meigen), Lucilia cuprina (Wiedemann), Cochliomyia macellaria (Fabricius), and Chrysomya rufifacies (Macquart) and evaluated their performance. Band detection rates were found to range from 71 to 100%, call rates ranged from 90 to 100%, and no error was found when bands could be called. Such information is informative for purposes of testimony and in preparation for development studies. The developed assays will assist in further differentiating sexually dimorphic differences in development of the Calliphoridae and aid in more accurately estimating insect age when age predictive markers (size, development time, molecular expression) are sexually dimorphic.
Associations between general and abdominal obesity and incident diabetic neuropathy in participants with type 2 diabetes mellitus
Authors: Zhou Rui , Li Furong , Chen Guochong , Fu Qiang , Gu Shanyuan , Wu Xianbo 
Published: June 2020

AbstractBackgroundPrevious epidemiological evidence on the sex‐specific association of obesity, particularly abdominal obesity, as reflected by larger waist circumference (WC), with incident diabetic neuropathy (DN) remains limited.MethodsWe used data from a patient cohort with a median 10‐year history of type 2 diabetes mellitus at the time of recruitment. A composite outcome of four types of predefined DN (Neuro 1‐4) was used as the outcome of interest. Because of sex differences in abdominal obesity, analyses were conducted separately for men and women.ResultsAmong the 7442 participants (4551 men and 2891 women) recruited in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, 3999 cases of incident DN were documented (2529 in men and 1470 in women). Larger WCs were associated with a higher risk of DN among both men and women. Compared with the lowest quintile, the hazard ratio (HR) for the highest quintile was 1.30 (95% CI 1.13‐1.49) among men (Ptrend <.001). For women, the HR for the highest vs lowest quintile was 1.25 (95% CI 1.04‐1.51) (Ptrend <.001). A linear relationship between WC and DN was observed in men, and in women, the risk of DN increased as the WC quintile increased before it appeared to plateau. The relationship between body mass index and incident DN was similar to the results observed for WC.ConclusionGeneral and abdominal obesity were both associated with an increased risk of incident DN among individuals with type 2 diabetes mellitus, regardless of sex.
Oasis Functional Stability Evaluation Based on Multiple Indicators, Northwest China
Authors: LI Sen , ZHANG Zhishan , WANG Tao , YAN Changzhen , DU Heqiang 
Published: June 2020

AbstractWe produced and analyzed oasis structure information, and evaluated oasis functional stability using the multiple indicators based on Remote Sensing (RS) and Geographical Information System (GIS) in the arid region of China in 2015. The results showed that the oases area was 193,734 km2, accounting for 8.17% of the arid region of China. The spatial difference in the functional stability of oases was obvious. The Beijiang zone had the highest functional stability and was relatively stable state, and the Hexi Corridor‐Alashan Plateau zone had the lowest functional stability and was relatively unstable. The functional stability is dominated by production and ecological functions, which have regional differences. Increasing oasis agricultural output, strengthening highway infrastructure construction and paying attention to education will become important ways to improve oasis functional stability. Water resources determine the ecological function, thus affecting the oasis functional stability. The results provide references for the formulation of related policies according to local conditions.
Quantitative trait loci mapping of adult‐plant resistance to powdery mildew in triticale
Authors: Karbarz Małgorzata , Tyrka Mirosław , Woźniak‐Strzembicka Anna , Czajowski Grzegorz , Wardyńska Agnieszka , Tyrka Dorota , Pojmaj Mirosław , Wędzony Maria 
Published: June 2020

AbstractPowdery mildew (PM) is a common disease caused by Blumeria graminis, which affects cereals and has recently adapted to triticale. Adult‐plant resistance (APR) genes provide durable protection of crops from the disease. Quantitative trait loci corresponding to the APR effects were mapped in an F2 population of “Lamberto” (susceptible) × “Moderto” (resistant). A genetic map of winter triticale was constructed based on the segregation of 863 DArT, 38 microsatellite and 10 resistance gene analogue markers. Composite interval mapping (CIM) was applied to identify three QTLs for maximum disease severity (MDS) and two for the area under disease progress curve (AUDPC) conferring resistance to the powdery mildew on chromosomes: 6A, 7A, 1B and 4R. The 39% variation in AUDPC was explained by the main QTL localised on chromosome 4R. Genes coding TRIUR3 proteins, serine/threonine protein kinase and cell wall associated kinases were localised in silico within the QTL and alternative DNA markers were proposed for flexible use in laboratories of diversified throughput.
A randomised controlled trial of fibrinogen concentrate during scoliosis surgery
Authors: Chen W. , Shen J. , Zhang Y. , Hu A. , Liang J. , Ma L. , Yu X. , Huang Y. 
Published: June 2020

SummaryBleeding and blood transfusion are common after scoliosis surgery. Fibrinogen is essential for blood clot formation and depletes quickly during haemorrhage. We randomly allocated 102 children 12–18 years old having surgery for idiopathic scoliosis, 51 to intra‐operative fibrinogen concentrate 30 mg.kg−1 (maximum 2 g) and 51 to saline placebo. Fibrinogen reduced peri‐operative blood loss by a median (95%CI) volume of 155 (5–320) ml, from a median (IQR [range]) of 1035 (818–1420 [400–3030]) ml to 885 (755–1155 [270–2645]) ml, p = 0.04. Seven and four children received allogeneic red blood cell transfusion after fibrinogen and placebo, respectively, p = 0.34. There were no side‐effects.
Subendocardial stress in pre‐eclampsia
Authors: Tran Tomio , Farasat Morteza , Krantz Mori J. 
Published: June 2020

AbstractA primigravida 26‐year‐old woman who had developed pre‐eclampsia with malignant hypertension at 30 weeks of gestation suffered acute myocardial infarction two days postpartum. Electrocardiogram demonstrated diffuse ST‐segment depression suggestive of subendocardial ischemia. Echocardiography demonstrated focal asymmetric left ventricular hypertrophy, with a characteristic “basal septal bulge”, and a left ventricular mid‐cavitary gradient of 51 mmHg. Coronary angiography revealed normal coronary arteries and vascular flow. Peripartum acute myocardial infarction is rare and portends a high mortality. However, to date, only one case of acute myocardial infarction associated with asymmetric left ventricular hypertrophy and pre‐eclampsia has been described in the literature.
Genetic landscape of external auditory canal squamous cell carcinoma
Authors: Sato Kuniaki , Komune Noritaka , Hongo Takahiro , Koike Kensuke , Niida Atsushi , Uchi Ryutaro , Noda Teppei , Kogo Ryunosuke , Matsumoto Nozomu , Yamamoto Hidetaka , Masuda Muneyuki , Oda Yoshinao , Mimori Koshi , Nakagawa Takashi 
Published: June 2020

AbstractExternal auditory canal squamous cell carcinoma (EACSCC) is an extremely rare and aggressive malignancy. Due to its rarity, the molecular and genetic characteristics of EACSCC have not yet been elucidated. To reveal the genetic alterations of EACSCC, we performed whole exome sequencing (WES) on 11 primary tumors, 1 relapsed tumor and 10 noncancerous tissues from 10 patients with EACSCC, including 1 with a rare case of synchronous bilateral EACSCC of both ears. WES of the primary tumor samples showed that the most frequently mutated gene is TP53 (63.6%). In addition, recurrent mutations in CDKN2A, NOTCH1, NOTCH2, FAT1 and FAT3 were detected in multiple samples. The mutational signature analysis of primary tumors indicated that the mutational processes associated with the activation of apolipoprotein B mRNA‐editing enzyme catalytic polypeptide‐like (APOBEC) deaminases are the most common in EACSCC, suggesting its similarity to SCC from other primary sites. Analysis of arm‐level copy number alterations detected notable amplification of chromosomes 3q, 5p and 8q as well as deletion of 3p across multiple samples. Focal chromosomal aberrations included amplifications of 5p15.33 (ZDHHC11B) and 7p14.1 (TARP) as well as deletion of 9p21.3 (CDKN2A/B). The protein expression levels of ZDHHC11B and TARP in EACSCC tissues were validated by immunohistochemistry. Moreover, WES of the primary and relapsed tumors from a case of synchronous bilateral EACSCC showed the intrapatient genetic heterogeneity of EACSCC. In summary, this study provides the first evidence for genetic alterations of EACSCC. Our findings suggest that EACSCC mostly resembles other SCC.
Prescription patterns of opioids and non‐steroidal anti‐inflammatory drugs in the first year after living kidney donation: An analysis of U.S. Registry and Pharmacy fill records
Authors: Vest Luke S. , Sarabu Nagaraju , Koraishy Farrukh M. , Nguyen Minh‐Tri , Park Meyeon , Lam Ngan N. , Schnitzler Mark A. , Axelrod David , Hsu Chi Yuan , Garg Amit X. , Segev Dorry L. , Massie Allan B. , Hess Gregory P. , Kasiske Bertram L. , Lentine Krista L. 
Published: June 2020

AbstractWe examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007‐2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0‐14 days, 15‐182 days, and 183‐365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio, LCLaORUCL). Among 23,565 donors, opioid prescriptions were highest during days 0‐14 (36.6%), but 12.6% of donors filled opioids during days 183‐365. NSAID prescriptions rose from 0.5% during days 0‐14 to 3.3% during days 183‐365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183‐365 included obesity (aOR,1.241.381.53), less than college education (aOR,1.191.311.43), smoking (aOR,1.331.451.58), and nephrectomy complications (aOR,1.111.291.49). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new‐onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer‐term outcome implications to help inform safe analgesic regimen choices after donation.
Seventy Years of Economic Development: A Review from the Angle of New Structural Economics
Authors: Lin Justin Yifu , Wang Yan 
Published: June 2020

AbstractThis review paper provides a new narrative by combing through the experiences of structural transformation among developing countries and discussing the roles of government and market in different contexts. Country performance has been influenced by the prevailing development thinking: the structuralism in the 1950s–1970s, which stresses an active government's role to overcome market failures for industrialization, and the neoliberalism in the 1980s–present, which advocates for eliminating government failures to build up a well‐functioning market. We find that almost all countries failing by following structuralism in their industrialization and neoliberalism in their transition to a market economy, and the few countries successful in catching up have a few characteristics that go against the prevailing structuralism and neoliberalism. The new structural economics, generated from the experiences of successful East Asian economies and proposing active facilitating roles of government in a market economy to remove market failures, will gain traction and take root.
Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer
Authors: Xian Jie , Cheng Yu , Qin Xue , Cao Yijia , Luo Yetao , Cao Youde 
Published: June 2020

AbstractNumb is known as a cell fate determinant as it identifies the direction of cell differentiation via asymmetrical partitioning during mitosis. It is considered as a tumour suppressor, and a frequent loss of Numb expression in breast cancer is noted. Numb forms a tri‐complex with p53 and E3 ubiquitin ligase HDM2 (also known as MDM2), thereby preventing the ubiquitination and degradation of p53. In this study, we examined Numb expression in 125 patients with triple‐negative breast cancer (TNBC). The results showed that 61 (48.8%) patients presented with a deficient or decreased Numb expression. The percentage of Ki67 > 14% in the retained Numb group was significantly lower than that in the decreased and deficient Numb groups (86.00% vs. 98.40%, P = .0171). This study aimed to detect the expression and migration of Numb, HDM2 and p53 in the membrane, cytoplasmic and nuclear fractions of normal mammary epithelial cell line MCF‐10A and basal‐like TNBC cell line MDA‐MB‐231. We obtained the cell fractions to identify changes in these three protein levels after the re‐expression of NUMB in the MDA‐MB‐231 cells and the knocking down of NUMB in the MCF‐10A cells. Results showed that Numb regulates p53 levels in the nucleus where the protein levels of Numb are positively correlated with p53 levels, regardless if it is re‐expressed in the MDA‐MB‐231 cells or knocked down in the MCF‐10A cells. Moreover, HDM2 was remarkably decreased only in the membrane fraction of NUMB knock‐down cells; however, its mRNA levels were increased significantly. Our results reveal a previously unknown molecular mechanism that Numb can migrate into the nucleus and interact with HDM2 and p53.
The importance of leaf surface wax as short‐range attractant and oviposition stimulant in a generalist Lepidoptera
Authors: Mobarak Syed Husne , Koner Anamika , Mitra Saubhik , Mitra Paroma , Barik Anandamay 
Published: June 2020

AbstractGreen gram, Vigna radiata (L.) Wilczek, is an important pulse crop of Asia. Severe attack by the larvae of Spilosoma obliqua Walker (Lepidoptera: Arctiidae) causes defoliation of green gram and reduces seed yield. Females lay eggs on the leaf surface, and therefore, surface wax plays an important role as short‐range attractant and oviposition stimulant. So, we have attempted to find out whether leaf surface wax compounds (alkanes and free fatty acids) from three green gram cultivars (PDM 54, PUSA BAISAKHI and SAMRAT) could act as short‐range attractant and oviposition stimulant in females. The TLC, GC‐MS and GC‐FID analyses of n‐hexane extracts revealed 20 n‐alkanes from n‐C15 to n‐C36 and 13 free fatty acids from C12:0 to C21:0, whilst linoleic acid was unique in SAMRAT. Pentacosane was the predominant amongst n‐alkanes in the leaf surface waxes of three cultivars. Heneicosanoic acid and palmitoleic acid were the predominant free fatty acids in the leaf surface waxes of PDM 54, and PUSA BAISAKHI and SAMRAT, respectively. Females were attracted towards one leaf equivalent surface wax of three green gram cultivars against solvent controls (n‐hexane) in Y‐tube olfactometer bioassays. A synthetic blend of pentacosane, heptacosane, nonacosane, hexatriacontane, palmitoleic acid, linolenic acid and stearic acid, a synthetic blend of pentacosane, hexatriacontane and stearic acid, and a synthetic blend of hexatriacontane, linolenic acid and stearic acid resembling in amounts present in one leaf equivalent surface wax of PDM 54, PUSA BAISAKHI and SAMRAT, respectively, served as short‐range attractant and oviposition stimulant in females. Females showed equal preference for egg laying towards the above three synthetic blends when these blends were tested against each other, and hence, these blends could be employed in development of baited traps in pest management strategies.