bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of bubble velocity, size, and holdup distribution between single‐ and double‐air inlet in jet microbubble generator
Authors: Li Xiaoheng , Su Wenbing , Liu Yu , Yan Xiaokang , Wang Lijun , Zhang Haijun 
Published: December 2020

AbstractThe jet microbubble generator is often used to produce bubbles in flotation equipment, which generates microbubbles by self‐absorbing or inflating. Bubble behavior is a dominant factor in froth flotation, and its velocity, size, and distribution greatly affect flotation performance. However, the asymmetry distribution of the pressure, bubble velocity, and gas holdup in generator with single inlet probably causes eccentric wear to the equipment. Therefore, in this study, using particle image velocimetry (PIV), high‐speed dynamic camera, and computational fluid dynamics (CFD) technology, the bubble behaviors in the jet microbubble generators with single inlet and double inlet was studied. The results show that under air flux of 0.4 L/min, the change of bubble diameter (D32) in two generators is obvious, reducing by 5.97% and 3.77% under circulation water flux of 1.5 and 2.5 m3/h, respectively. Comparing the influence of circulating water fluxes, the double‐inlet structure can reduce the bubble diameter more effectively. The maximum turbulent dissipation rate in the throat section of the generator with double inlet is greater than 120, while it is less than 100 in single‐inlet structure. For bubbles in generator with double inlet, velocity difference in radial direction reduces to 0.03 m/s and is more symmetrical. Meanwhile, the double‐inlet generator can also optimize the uniformity gas holdup distribution, which is beneficial to increase the collision probability of flotation and reduce the abrasion of microbubble generator.
Risk factors and their diagnostic values for ocular metastases in invasive ductal carcinoma
Authors: Liang Rong‐Bin , Yu Kang , Wu Jie‐Li , Liu Jia‐Xiang , Lin Qi , Li Biao , Zhang Yu‐Qing , Ge Qian‐Min , Li Qiu‐Yu , Shu Hui‐Ye , Shao Yi 
Published: December 2020

AbstractInvasive ductal carcinoma (IDC) is a major type of breast cancer. Ocular metastasis (OM) in IDC is rarely seen, but patients with OM often have a poor prognosis. Furthermore, OM is difficult to detect in the early stages by common imaging examinations. In the present study, we tried to figure out the risk factors of OM in IDC and evaluate their diagnostic values for early detection. There were 1192 IDC patients who were divided into two groups according to ocular metastasis involved in this study. Clinical parameters of those patients were used to detect differences. The binary logistic regression test was then used to determine the risk factors of OM in IDC. Furthermore, ROC curves of both single and combined risk factors were established to examine their diagnostic values. The incidence of axillary lymph node metastases was significantly higher in the OM group (p = 0.002). Higher carbohydrate antigen 153 (CA153), lower apolipoprotein A1 (ApoA1), and hemoglobin (Hb) were risk factors for OM in IDC (p < 0.001, p < 0.001, p = 0.038, respectively). In the single risk factor ROC analysis, cutoff values of CA153, ApoA1, and Hb were 43.3 u/mL (CI: 0.966–0.984, p < 0.001), 1.11 g/L (CI: 0.923–0.951, p < 0.001), and 112 g/L (CI: 0.815–0.857, p < 0.001), respectively. Among the ROC curves of combined risk factors, CA153+ApoA1+Hb had the best accuracy, with the sensitivity and specificity of 89.47% and 99.32%, respectively (CI: 0.964–0.983, p < 0.001). CA153, ApoA1, and Hb are risk factors for OM in IDC. In clinical practice, the three parameters could be used as predictive factors for the early detection of OM.
Use of Copper as a Trigger for the in Vivo Activity of E. coli Laccase CueO: A Simple Tool for Biosynthetic Purposes
Authors: Decembrino Davide , Girhard Marco , Urlacher Vlada B. 
Published: December 2020

AbstractLaccases are multi‐copper oxidases that catalyze the oxidation of various electron‐rich substrates with concomitant reduction of molecular oxygen to water. The multi‐copper oxidase/laccase CueO of Escherichia coli is responsible for the oxidation of Cu+ to the less harmful Cu2+ in the periplasm. CueO has a relatively broad substrate spectrum as laccase, and its activity is enhanced by copper excess. The aim of this study was to trigger CueO activity in vivo for the use in biocatalysis. The addition of 5 mM CuSO4 was proven effective in triggering CueO activity at need with minor toxic effects on E. coli cells. Cu‐treated E. coli cells were able to convert several phenolic compounds to the corresponding dimers. Finally, the endogenous CueO activity was applied to a four‐step cascade, in which coniferyl alcohol was converted to the valuable plant lignan (−)‐matairesinol.
Synthetic Phenolic Glycolipids for Application in Diagnostic Tests for Leprosy
Authors: van Dijk J. Hessel M. , van Hooij Anouk , Groot L. Melanie , Geboers Jolijn , Moretti Rosita , Verhard‐Seymonsbergen Els , de Jong Danielle , van der Marel Gijs A. , Corstjens Paul L. A. M. , Codée Jeroen D. C. , Geluk Annemieke 
Published: December 2020

AbstractPoint‐of‐care (POC) diagnostic tests for the rapid detection of individuals infected with Mycobacterium leprae, the causative pathogen of leprosy, represent efficient tools to guide therapeutic and prophylactic treatment strategies in leprosy control programs, thus positively contributing to clinical outcome and reducing transmission of this infectious disease. Levels of antibodies directed against the M. leprae‐specific phenolic glycolipid I (PGL−I) closely correlate with an individual's bacterial load and a higher risk of developing leprosy. We describe herein the assembly of a set of PGL glycans carrying the characteristic phenol aglycon and featuring different methylation patterns. The PGL trisaccharides were applied to construct neoglycoproteins that were used to detect anti‐PGL IgM antibodies in leprosy patients. ELISAs and quantitative lateral‐flow assays based on up‐converting nanoparticles (UCP‐LFAs) showed that the generated PGL−I and PGL‐II trisaccharide neoglycoconjugates can be applied for the detection of anti M. leprae IgM antibodies in POC tests.
Selective immunoglobulin M deficiency in a patient with celiac disease and recurrent pneumonia
Authors: Heidarzadeh Arani Marziyeh , Razavizadeh Mohsen , ArefNezhad Reza , Motedayyen Hossein 
Published: December 2020

AbstractSIgMD is a rare immune disorder that occurs in a primary or secondary condition. Patients with recurrent infectious, cancers, and autoimmune disorders should be investigated to determine SIgMD.
Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report
Authors: Descamps Vincent , Gautheret‐Dejean Agnès , Pelletier Anne‐Laure , Bonnafous Pascale , Deschamps Lydia , Prusty Bhupesh K. 
Published: December 2020

AbstractA sulfasalazine‐induced DRESS (Drug Reactivation with Eosinophilia and Systemic Symptoms) was complicated by a Crohn's‐like colitis. We demonstrated HHV‐6 reactivation with presence of HHV‐6 DNA and small noncoding RNA in colonic lesions. This observation confirms the major role of HHV‐6 reactivation in DRESS manifestations and the importance of looking for HHV‐6 reactivation in DRESS.
All‐MXene Cotton‐Based Supercapacitor‐Powered Human Body Thermal Management System
Authors: Li Jianmin , Chen Jianmei , Wang Hao , Xiao Xu 
Published: December 2020

AbstractPersonal body thermal management (PBTM) has shown great potential in the application of artificial skin, smart clothing, and health care for the rapidly developed flexible electronics and “Internet of Things”. However, the heating efficiencies of the previously reported PBTM systems are relatively low with low response rate and high driving voltage, which are not satisfying for wearable devices. Here, we report a MXene‐coated cotton fabric (MCF)‐based PBTM system, which shows good water vapor permeability, air permeability, wear resistance, and wash stability. The optimal MCF shows high electron conductivity of 197 mS cm−2 and high heating efficiency, which could be heated up to 100 °C within 10 s under the low applied potential of 3 V. By applying a low voltage of 1.5 V, the MCF exhibited a high temperature of 45 °C, meeting the requirement of human body. In addition, serving as the electrode material of supercapacitors, the MCF exhibits high areal specific capacitance of 208 mF cm−2 at a scan rate of 5 mV s−1. The symmetric supercapacitor device could provide a high energy density of 2 μWh cm−2 and power density of 5.3 mW cm−2. Using the MCF‐based symmetric supercapacitor as the power source, the MCF could be heated and employed as a supercapacitor‐powered PBTM system, which indicates its significant potential for the application of wearable PBTM and beyond.
Color Tuning of Fluorogens for FAST Fluorogen‐Activating Protein
Authors: Myasnyanko Ivan N. , Gavrikov Alexey S. , Zaitseva Snizhana O. , Smirnov Alexander Yu. , Zaitseva Elvira R. , Sokolov Anatolii I. , Malyshevskaya Kseniya K. , Baleeva Nadezhda S. , Mishin Alexander S. , Baranov Mikhail S. 
Published: December 2020

AbstractUsing benzylidene imidazolone core, we created a panel of color‐shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live‐cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live‐cell fluorogenic labeling tools.
Internet of things in health management systems: A review
Authors: Huang Jinbo , Wu Xianjun , Huang Wendong , Wu Xiaoli , Wang S. 
Published: December 2020

SummaryIn today's health care context, the application of the Internet of Things (IoT) offers suitability for doctors and patients as we can use them in many medical fields. So, we have emphasized the particular use of the IoT in medicine and health care, such as clinical devices management, medication management, clinical data management, distant medicine, mobile medical care, and individual health management. We have done an organized review to enhance health management systems via many up‐to‐date IoT‐oriented health care applications. The article approbates with the methodological necessities of systematic literature reviews. We have identified several issues caused by the quick acceptance of IoT‐oriented systems' health management. IoT necessitates new safety infrastructure, according to the novel practical principles. Outcomes illustrate that health experts can assist in supplying necessities, information, or standards to improve IoT devices or systems. Also, they are able to present novel fields or applications for which IoT is fit. This survey aids the hospitals and relevant institutions to recognize IoT needs. Also, the article will serve as an initial location for future IoT security management and design. Policymakers and opinion formers need to understand the IoT and its implications.
Comparing population trend estimates of migratory birds from breeding censuses and capture data at a spring migration bottleneck
Authors: Maggini Ivan , Cardinale Massimiliano , Favaretto Andrea , Voříšek Petr , Spina Fernando , Maoret Francesco , Ferri Andrea , Riello Sara , Fusani Leonida 
Published: December 2020

AbstractEurope has a well‐established network of breeding bird monitoring that is used to produce supranational indices of population trends for many species. However, a comparison of breeding bird censuses with other methods may be beneficial to confirm the validity of such indices. The aim of this study was to assess the value of standardized capture data of migratory birds at migration bottlenecks as an indicator of the effective breeding populations. One limitation to this method is that several populations are co‐occurring at these bottlenecks and their catchment areas need to be clearly identified to allow extrapolation of population indices. Here, we used standardized trends in capture numbers of 30 species on the island of Ponza, a migration bottleneck in the central Mediterranean, and compared them to population trends estimated in the putative catchment breeding areas between 2005 and 2016. The catchment areas were identified through the analysis of ring recoveries during the breeding season of birds passing through Ponza. Our results show an agreement between the population trends observed on Ponza and those in the breeding areas in 15 out of 30 species. The correlations were strongest in species with a more robust definition of the catchment areas, that is, species with more than 10 recoveries, and for which the recoveries were most likely of breeding birds. The main reason for disagreement between the two indices in the remaining species might be related to different intensity of sampling in different areas. This issue can be solved by further developing monitoring projects in underrepresented countries, as well as by intensifying monitoring through ringing, both in the breeding grounds and at migration bottlenecks. These results show that spring migration monitoring at bottlenecks has the potential to provide a valuable complement and an independent control of breeding bird surveys, allowing raising early warnings of population declines and contributing to their conservation.
Time‐traveling seeds reveal that plant regeneration and growth traits are responding to climate change
Authors: Everingham Susan E. , Offord Catherine A. , Sabot Manon E. B. , Moles Angela T. 
Published: December 2020

AbstractStudies assessing the biological impacts of climate change typically rely on long‐term, historic data to measure trait responses to climate through time. Here, we overcame the problem of absent historical data by using resurrected seeds to capture historic plant‐trait data for a number of plant regeneration and growth traits. We collected seed and seedling trait measurements from resurrected historic seeds and compared these with modern seed and seedling traits collected from the same species in the same geographic location. We found a total of 43 species from southeastern Australia for which modern/historic seed pairs could be located. These species were located in a range of regions that have undergone different amounts of climate change across a range of temperature, precipitation, and extreme measures of climate. There was a correlation between the amount of change in climate metrics, and the amount of change in plant traits. Using stepwise model selection, we found that for all regeneration and growth trait changes (except change in stem density), the most accurate model selected at least two measures of climate change. Changes in extreme measures of climate, such as heat‐wave duration and changes in climate variability, were more strongly related to changes in regeneration and growth traits than changes in mean climate metrics. Across our species, for every 5% increase in temperature variability, there was a threefold increase in the probability of seed viability and seed germination success. An increase of 1 d in the maximum duration of dry spells through time led to a 1.5‐fold decrease in seed viability and seeds became 30% flatter/thinner. Regions where the maximum heat‐wave duration had increased by 10 d saw a 1.35‐cm decrease in seedling height and a 1.04‐g decrease in seedling biomass. Rapid responses in plant traits to changes in climate may be possible; however, it is not clear whether these changes will be fast enough for plants to keep pace with future climate change.
KLiSiF6 and CsLiSiF6 – A Structure Investigation
Authors: Stoll Christiane , Seibald Markus , Baumann Dominik , Bandemehr Jascha , Kraus Florian , Huppertz Hubert 
Published: December 2020

AbstractKLiSiF6 and CsLiSiF6 were synthesized via a high‐pressure/high‐temperature synthesis route. Even though, both substances crystallize in the orthorhombic crystal system with space group Pbcn (no. 60), they show different crystal structures. Main motifs of KLiSiF6 are an [SiF6]2− and an [LiF6]5− unit. In contrast, the main motifs of CsLiSiF6 are an [SiF6]2− and an [LiF5]4− entity. Within both substances, these units are interconnected and form 3‐dimensional networks. The substances were characterized via single‐crystal and powder X‐ray diffraction, as well as infrared spectroscopy and EDX measurements. Additionally, Mn4+‐doped KLiSiF6 was analyzed by means of luminescence spectroscopy. It displays line emission in the red spectral region. The maximum emission wavelength is λmax=631 nm.
Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism
Authors: Ikeda Yuko , Matsukawa Yuko , Yonekura Kyohei , Shirakawa Eiji 
Published: December 2020

AbstractIn the presence of a substoichiometric amount of a tert‐butoxy radical precursor and a base, alkylamides were found to be heteroarylated at their α‐C−H bonds with sulfonylheteroarenes through homolytic aromatic substitution, where a radical chain is operative.
Chiral Molecular Cages Based on Cyclotriveratrylene and Sucrose Units Connected with p‐Phenylene Linkers
Authors: Szyszka Łukasz , Cmoch Piotr , Górecki Marcin , Ceborska Magdalena , Potopnyk Mykhaylo A. , Jarosz Sławomir 
Published: December 2020

AbstractFour diastereomeric molecular cages based on cyclotriveratrylene (CTV) and sucrose scaffolds, connected via p‐phenylene linkers, were synthesized in a few steps synthesis. The absolute configuration of these diastereoisomers was determined by advanced NMR and ECD spectroscopies supported by DFT calculations. The X‐Ray crystal structure of P‐4 b cage gave an insight into its unique structure. The binding properties of P‐4 a and M‐4 a cages towards small ammonium guests (1‐methylpyridinium and 1,3‐dimethylimidazolium salts) were investigated.
Insights about sustainable biodiesel production from microalgae biomass: A review
Authors: Rahul S Michael , MA Sundaramahalingam , CS Shivamthi , R Shyam Kumar , P Varalakshmi , S Karthikumar , J Kanimozhi , R Vinoth Kumar , S Sabarathinam , I Ganesh Moorthy , A Pugazhendhi 
Published: December 2020

SummaryProduction of biodiesel from microalgae can be categorized as a symbiotic engineering solution focusing on energy and environmental problems. This review presents a collection of recent methods adopted for the production of biodiesel from microalgae. Microalgae are tiny cell factories which yield a large quantity of biomass by employing different methods of cultivation and using different types of harvesting techniques. Different strategies like nutrient starvation and micronutrient supplementation for hyper lipid accumulation to produce biodiesel for competing with the high market demand for fossil fuel are discussed. The use of different cultivation techniques for increasing the algal biomass in the recent scenario is focused. Also, improvement in the design strategies of bioreactors like the open pond, photobioreactors, and hybrid systems is included in the review. Further, diverse technologies for lipid improvement, including manipulating the bioprocess parameters and genetic engineering, are addressed. Also, microalgae for biorefinery approaches solve pollution problems, and its biomass can be used for biodiesel production which is elaborated in detail. The possibility of production of biodiesel from microalgae at a larger scale by overcoming the main bottlenecks in different steps of algal growth like high biomass cultivation, investment factor, and implementation of biorefinery approaches to address the current energy demand is also proposed.
Grabbing hand or helping hand? Ownership interventions and acquirers returns; the role of provincial idiosyncrasies
Authors: Opoku‐Mensah Evans , Yin Yuming , Obiora Sandra Chukwudumebi , Adjei Darko Peter 
Published: December 2020

AbstractFirm's performance is not only influenced by sound decisions but also by institutional processes. This study argues that the effect of government intervention on acquisition returns is partly dependent on institutional factors such as provincial marketization and the legal environment. This study employs ownership and merger and acquisition regulations issued by the Chinese government 2003–2018 to measure government intervention and also employs both the OLS and the random effects technique. The result shows a positive relationship between ownership intervention and acquisition returns. Next, the study finds that variances in regional marketization and the legal environment strengthen this relationship such that acquirers in high marketization regions and acquirers in a robust legal environment earn higher returns than acquirers in a low marketization region and acquirers in a weaker legal environment. The results imply that acquisition returns are not even across all locations in a transitional economy. Ongoing policies should aim at bridging the variances in different locations as it impacts acquirers' returns.
Abnormal Bone Collagen Cross‐Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations
Authors: Gistelinck Charlotte , Weis MaryAnn , Rai Jyoti , Schwarze Ulrike , Niyazov Dmitriy , Song Kit M , Byers Peter H , Eyre David R 
Published: December 2020

ABSTRACTBruck syndrome (BS) is a congenital disorder characterized by joint flexion contractures, skeletal dysplasia, and increased bone fragility, which overlaps clinically with osteogenesis imperfecta (OI). On a genetic level, BS is caused by biallelic mutations in either FKBP10 or PLOD2. PLOD2 encodes the lysyl hydroxylase 2 (LH2) enzyme, which is responsible for the hydroxylation of cross‐linking lysine residues in fibrillar collagen telopeptide domains. This modification enables collagen to form chemically stable (permanent) intermolecular cross‐links in the extracellular matrix. Normal bone collagen develops a unique mix of such stable and labile lysyl‐oxidase–mediated cross‐links, which contribute to bone strength, resistance to microdamage, and crack propagation, as well as the ordered deposition of mineral nanocrystals within the fibrillar collagen matrix. Bone from patients with BS caused by biallelic FKBP10 mutations has been shown to have abnormal collagen cross‐linking; however, to date, no direct studies of human bone from BS caused by PLOD2 mutations have been reported. Here the results from a study of a 4‐year‐old boy with BS caused by compound heterozygous mutations in PLOD2 are discussed. Diminished hydroxylation of type I collagen telopeptide lysines but normal hydroxylation at triple‐helical sites was found. Consequently, stable trivalent cross‐links were essentially absent. Instead, allysine aldol dimeric cross‐links dominated as in normal skin collagen. Furthermore, in contrast to the patient's bone collagen, telopeptide lysines in cartilage type II collagen cross‐linked peptides from the patient's urine were normally hydroxylated. These findings shed light on the complex mechanisms that control the unique posttranslational chemistry and cross‐linking of bone collagen, and how, when defective, they can cause brittle bones and related connective tissue problems. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.