bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Analysis, and Experimental Validation to Uncover the Mechanism of the Four Compounds in Artemisia annua (Qing Hao) Antimalarial
Authors: zhao yuping , Zhang Xiao-bo , Xu Hai-yu , Wang Ling , Huang Lu-qi 
Published: November 2020

Abstract
Background: Artemisinin is widely used to treat malaria, but the antimalarial mechanism and coordinative interactions governing the actions of artemisinin, scopoletin, arteannuin B and artemisinic acid have not been elucidated. Methods: Based on the existence of antimalarial drugs, the antimalaria targets of artemisinin, scopoletin, arteannuin B and artemisinic acid were investigated by molecular docking using the similarity theory of chemical structure, and the antimalaria mechanism of scopoletin and its coordinative antimalaria interactions with the other three ingredients of the mixture were subsequently examined. Results: Using the text information excavation method, the relevant proteins involved in the antimalarial effect of artemisinin were IL-6, ACHE, PC3, IPOB, CYC, TNF-α, UGT1A9, CASP3, XDH, IL-1β, VEGF, CAT, CREB, AMPK, UGT1A6, ADR, MAPK, COX2, LB24AB and CYP450. The relevant proteins involved in the antimalarial effect of scopoletin were TNF-α, PI3K, IL-8, IL- 6, VEGF, IL-1β, MAPK, CD4, SP2, CTNNB, CASP3, PRO1400, IgE, IL-4, ICAM1, p38, STAT3, TLR4 and API4. However, arteannuin B and artemisinic acid had little relevance to the abovementioned proteins. The interaction property between TNF-α and Artemisia annua was that the effect of the mixture of artemisinin, scopoletin, arteannuin B and artemisinic acid was greater than that of artemisinin alone, and the synergistic effect of the four elements was considered beneficial to the progress of antimalarial treatment. Conclusion: The antimalarial targets of Artemisia annua ingredients were examined using data mining methods, and the antimalarial effect of scopoletin may be related to TNF. The combined application of the four elements achieved the same antimalarial effect and reduced the clinical use of artemisinin and scopoletin.
Challenges and Opportunities for School-based Sexual and Reproductive Health Education: A Qualitative Study with Bangladeshi Islamic Leaders
Authors: Ali Mohammad , Arousell Jonna , Essén Birgitta , Ugarte William 
Published: November 2020

Abstract
BackgroundIt has been argued that Islamic leaders’ views are of utmost importance to designing a comprehensive sexual education (CSE) curriculum. Therefore, this study explored how Islamic leaders in Bangladesh present, argue for and against, and negotiate views on sexual and reproductive health (SRH) education for adolescents. MethodsSemi-structured interviews were conducted with seven Imams using thematic analysis. The study was conducted in urban and rural areas, specifically the capital, Dhaka, as well as several rural villages in the Cumilla district.ResultsWe found three main themes 1) appropriate topics for SRH education, 2) appropriate methods for SRH education, and 3) conservative versus progressive views. ConclusionWe conclude that Islamic leaders seemed willing to try finding ways to support more comprehensive and liberal SRH education if they would be encouraged by reflective and inclusive dialogue. This study presents an empirically grounded opportunity for policy makers to consider the future role for religious leaders in the provision of SRH in Bangladesh.
Predictive Value of Immunological Parameters in the Risk of Gestational Diabetes Mellitus: A Pilot Study
Authors: Fagninou Adnette , Nekoua Magloire Pandoua , Fiogbe Salomon Ezéchiel Mahougnon , Moutairou Kabirou , YESSOUFOU Akadiri 
Published: November 2020

Abstract
Background : Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here we assessed the predictive power of immunological parameters correlated with biochemical ones in gestational diabetes mellitus (GDM). Material and Methods : 217 pregnant women were screened for GDM between the 2 nd and the 3 rd trimester of gestation, based on IAGDP methods in this cross-sectional descriptive study. Immunological and biochemical parameters were determined using appropriate methods. Receiver operating characteristics (ROC) curve analyses were conducted to assess the optimal cutoff and value of immunological to biochemical parameter ratios for predicting GDM. Results : 11.90% of pregnant women were diagnosed GDM positive. Serum glucose levels, total cholesterol, LDL-cholesterol, triglycerides and total proteins were significantly increased while HDL-cholesterol decreased in women with GDM compared to controls. The levels of glycosylated hemoglobin and creatinine, as well as transaminase (AST and ALT) activities did not significantly differ between GDM and pregnant controls. Total leucocytes (white blood cell), lymphocyte and platelet numbers were significantly higher in women with GDM than in pregnant controls. We also found that the lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios were significantly higher in women with GDM than in pregnant controls ( p = 0.001; p = 0.009 and p = 0.004 respectively). Women with a lymphocyte:HDL-C ratio greater than 3.66 had a 4-fold increased risk of developing GDM than those with lower ratios (odds ratio 4.00; 95% CI: 1.094 – 14.630; p =0.041). Conclusion : The lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios may represent valuable makers, and the lymphocyte:HDL-C ratio in particular may have strong predictive power for GDM. This ratio can be easily assessed in patients.
What does it mean to be a principal? A policy researcher’s perspective on the last 30 years in Aotearoa New Zealand
Authors: Wylie Cathy 
Published: November 2020

Abstract
In this article I reflect on research relating to school leadership and the use of research to support school leadership over the last 30 years in Aotearoa New Zealand. The Tomorrow’s Schools reforms in 1989 wth its shift to school self-management saw more interest in understanding the size and nature of the principal role. More recently there has been interest among policymakers in using research to support effective school leadership, and revived attention to the place of school leadership in Aotearoa New Zealand’s education system.
This article is also intended to provide future Aotearoa New Zealand researchers into school leadership with some references they can use to chart how things change if new policy settings and supports for school leadership are introduced as a result of the Tomorrow’s Schools Independent Taskforce’s recommendations.
La lúdica como mediadora del aprendizaje para el desarrollo integral de
los niños de la primera infancia
Authors: Acevedo Montiel Lizeth Tatiana , Gómez Valencia María Verónica , Ortega Arrieta Jojanis María , Valencia Restrepo María del Pilar , Villa Cardona Luisa Fernanda 
Published: November 2020

En el presente artículo se abordará el principio de la lúdica como uno
de los ejes centrales de la educación preescolar, siendo este principio
fundamental para el aprendizaje y el desarrollo integral de los niños y
niñas en la primera infancia. Para sustentar el mencionado principio, este
artículo se basará en las experiencias significativas de la Práctica IV de
intervención psico-social, adscrita a la Licenciatura en Educación Infantil
de la Universidad Católica Luis Amigó, realizada en dos agencias de
diferentes contextos sociales; por tal motivo se contrastan ambos contextos
y se evidencia la implementación de la lúdica como mediador pedagógico en
los entornos sociales y cómo esta puede afectar o favorecer el desarrollo y
el aprendizaje de los niños y niñas.
Monthly runoff prediction using modified CEEMD-based weighted integrated model
Authors: Yan Xinqing , Chang Yuan , Yang Yang , Liu Xuemei 
Published: November 2020

Abstract
Due to the nonlinear characteristics of runoff data and the poor performance of the single prediction model, a weighted integrated modified complementary ensemble empirical mode decomposition (MCEEMD)-based model was proposed to predict the monthly runoff of three hydrological stations in the lower reaches of the Yellow River. In this model, particle swarm optimization (PSO) was used to optimize the parameters of support vector regression (SVR), back propagation neural network (BP), long short-term memory neural network (LSTM) that constitute it. The weight coefficients and frequency terms decomposed by MCEEMD were used to obtain the final prediction results. Results indicated that this model performs better than other models, with the Nash–Sutcliffe efficiency (NSE) reaching above 0.92, qualification rate (QR) reaching above 75% and all error indicators being minimal. In addition, considering the influence of extreme weather and climate anomalies, the integrated model combined the atmospheric circulation anomalies factors and the results can still be improved. It can be verified that this weighted integrated model can be used for the stable and accurate predication of medium- and long-term runoff.
Establishment and verification of the prediction model of soil wetting pattern size in vertical moistube irrigation
Authors: Fan Yanwei , Yang Zhiwei , Wei Hujun 
Published: November 2020

AbstractTo solve the difficulty of observing the soil wetting pattern of vertical moistube irrigation, the HYDRUS-2D software is used to simulate wetting pattern data under different conditions. Based on the analysis of Origin 9.0 and summarizing the law of simulation data, an empirical model for predicting wetting pattern size is constructed, with the reliability of the model verified by experimental data. The results show that the power function is used to fit the relationship between the size of wetting pattern and irrigation time. The power function exponent has small changes in three directions (vertical upward, horizontal, and vertical downward) of the moistube. Further analysis shows that the power function coefficient is in accordance with the power function relationship with soil-saturated hydraulic conductivity, the steady permeability of the moistube, and the difference between soil-saturated moisture content and initial moisture content. The average absolute error of statistical indicators of the built model is between 0.30 and 1.42 cm, the root mean square error is between 0.42 and 1.65 cm, and the Nash–Sutcliffe efficiency coefficient is not less than 0.93. The model has a good prediction effect and can provide a scientific basis for the design, operation, and management of the moistube irrigation engineering.
FermatS: A Novel Numerical Representation for Protein Sequence Comparison and DNA-binding Protein Identification
Authors: Zhang Yanping , Gao Ya , Ni Jianwei , Chen Pengcheng , Wang Xiaosheng 
Published: November 2020

Aims:
Based on protein sequence information, a simple and effective method was used
to analyze protein sequence similarity and predict DNA-binding protein.

Background:
It is absolutely necessary that we generate computational methods of low complexity
to accurate infer protein structure, function, and evolution in the rapidly growing number of
molecular biology data available.

Objective:
It is important to generate novel computational algorithms for analyzing and comparing
protein sequences with the rapidly growing number of molecular biology data available.

Method:
Based on global and local position representation with the curves of Fermat spiral and
normalized moments of inertia of the curve of Fermat spiral, respectively, moreover, composition
of 20 amino acids to get the numerical characteristics of protein sequences.

Results:
It has been applied to analyze the similarity/dissimilarity of nine ND5 proteins, the
analysis results are consistent with the biological evolution theory. Furthermore, we employ the
Logistic regression with 5-fold cross-validation to establish the prediction of DNA-binding
proteins model, which outperformed the DNAbinder, iDNA-prot, DNA-prot and gDNA-prot by
0.0069-0.609 in terms of F-measure, 0.293-0.898 in terms of MCC in unbalanced dataset.

Conclusion:
These results show that our method, namely FermatS, is effective to compare,
recognition and prediction the protein sequences.
Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles
Authors: Yaghoubi Hashem , Izadpanah Amin , Nedaei Shahla , Akbari Hossein , Mikaeiliagah Elmira , Mostany Ricardo , Chandrasekar Bysani , Alt Eckhard , Izadpanah Reza 
Published: November 2020

Background:
The use of nanoparticles has markedly increased in biomedical sciences.
The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver
chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing
chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic.

Methods:
Natural products have emerged as viable candidates for nanoparticle production,
including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family.
Accordingly, our goal was to synthesize AgNPs using an aqueous extract of T. boudieri (green
synthesized AgNPs). Since certain infectious agents are linked to cancer, we investigated their
potential as anti-cancer and antibacterial agents.

Results:
The synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm
by spectroscopy. The physico-chemical properties of green synthesized AgNPs were analyzed by
UV-Vis, FT-IR, XRD, SEM, and TEM. In addition, their potential to inhibit cancer cell
(proliferation and the growth of infectious bacteria were investigated.

Conclusion:
The size of nanoparticles ranged between 20-30nm. They exerted significant
cytotoxicity and bactericidal effects in a concentration and time-dependent manner compared to T.
boudieri extract alone. Interestingly, the synthesis of smaller AgNPs was correlated with longer
synthesis time and enhanced cytotoxic and bactericidal properties.
Anti-Ulcerogenic and Cytoprotective Effects of Saharian (Sidr) Honey from Algeria
Authors: Djebli Noureddine , Mustafa Mohammad Rais , Keskin Merve , Kolayli Sevgi 
Published: November 2020

Aim and Objective:
This study aimed at investigating the gastro-protective effects of Algerian Sahara (Sidr) honey
from Apis mellifera intermissa against HCl/Ethanol-induced gastric ulcers in rats

Material and Methods:
Total phenolic content, antioxidant activity and phenolic compounds were determined. Than, Three
groups of rats (control, HCl/ Ethanol induced ulcer, and orally administered honey) were used for the determination of gastro
protective effect of Sidr honey.

Results:
Total phenolic content, total flavonoid content, and DPPH activity of the honey sample
were determined as 47.35±3.35 mg GAE/100 g, 2.13±0.17 mg QE/100 g, and 229.24±0.02
mg/mL, respectively. Oral pretreatment of rats with honey (1.2 g/Kg body weight orally at an
interval of 2 days) protected gastric mucosa against HCl/Ethanol-induced damage by decreasing
ulcer score, the volume and acidity of gastric juice and increasing pH.

Conclusion:
These results were confirmed by the histological assessment, which demonstrated a
significant gastro-protective activity of Saharian (Sidr) honey against HCl/Ethanol-induced
stomach ulcer. Plasma tumor necrosis factor-α, IL-6 and PGE2 were also measured. Sahara honey
significantly decreased the plasma TNF-α, PGE2, and IL-6 concentrations.
A Review of Research Progress on Agathis dammara and its Application Prospects for Cardiovascular Diseases and Fatty Liver Disease
Authors: Wang Anyi , Yue Shanshan , Peng Ankang , Qi Rong 
Published: November 2020

:
Cardiovascular diseases and fatty liver disease have become the leading causes of death in
modern society. However, the currently existing drugs do not solve all issues related to these diseases;
thus, it is expected that more potential drugs for clinical use will be developed. Undeniably, natural
products have attracted increasing attention. It is of great significance to identify effective active
monomer components for drug discovery and disease prevention. As a pure natural product, Agathis
dammara (AD) has antioxidant, hypolipidemic, hypoglycemic, antitumor, and anti-inflammatory activities.
However, at present, there are few reports regarding the effects of AD on chronic inflammatory
cardiovascular diseases, such as aneurysm, atherosclerosis, myocardial ischemia-reperfusion injury,
and cardiac hypertrophy and liver diseases such as fatty liver disease. AD and products derived from it
have a very broad application prospect for cardiovascular diseases and fatty liver disease.
Inflammation-based Scores are Associated with the Prognosis of Patients with Aneurysmal Subarachnoid Hemorrhage After Neuro-intervention
Authors: Yi Ho Jun , Lee Dong Hoon , Sung Jae Hoon 
Published: November 2020

Objective:
Prognostic significance of inflammatory response has been reported in various
diseases. The objective of this study was to analyze the association between inflammation-
based scores and the prognosis of patients who underwent neuro-intervention for aneurysmal
subarachnoid hemorrhage (SAH).

Methods:
Inflammation-based scores such as neutrophil to lymphocyte ratio (NLR), lymphocyte to
monocyte ratio (LMR), and monocyte to high-density lipoprotein cholesterol (HDL-C) ratio
(MHR) were analyzed for aneurysmal SAH patients who underwent endovascular intervention. Unfavorable
functional outcome was defined as a modified Rankin Scale (mRS) score of 3-6. Receiver
operating characteristic (ROC) curve analysis was performed to identify cut-off values of inflammation-
based scores for predicting unfavorable functional outcome. Logistic regression analyses
were performed to explore the relationship between inflammation-based scores and the prognosis
of patients.

Results:
A total of 498 patients were enrolled. Optimal cutoff values of inflammation-based scores
of NLR, LMR, and MHR for unfavorable functional outcome were 5.7, 4.2, and 1.5, respectively
(p < 0.001, < 0.001, and 0.004, respectively). In multivariate analysis, NLR value ≥ 5.7 (odds ratio
[OR] 1.92, 95% CI 1.42–3.42; P = 0.008), LMR value < 4.2 (OR 1.74, 95% CI 1.48–2.98; P =
0.018), and MHR value ≥ 1.5 (OR 1.44, 95% CI 1.22–2.82; P = 0.040) were independently associated
with unfavorable functional outcome.

Conclusion:
Inflammation based scores were associated with functional outcome after endovascular
intervention for aneurysmal SAH. Higher NLR and MHR with lower LMR could predict unfavorable
outcomes of aneurysmal SAH patients who underwent endovascular intervention.
Fournier’s Gangrene Due to Salmonella Typhimurium in a Healthy Male: A Rare Aberrant Infection
Authors: Gupta Varsha , Singhal Lipika , Pal Kritika , Bhushan Mani , Sharma Rajeev , Chander Jagdish 
Published: November 2020

Introduction:
Human Salmonella infections have been classically distinguised into diseases caused by typhoidal
and non-typhoidal salmonella (NTS). Typhiodal salmonella includes S. enterica serovars Typhi and Paratyphi that cause the
systemic disease but are restricted to human infections, while NTS consists mainly of other serovars that predominantly
cause self-limiting gastroenteritis in humans. Localisation of foci with persisting infection occurs due to dissemination of the
bacteria throughout the body and can cause a variety of rare clinical syndromes at aberrant sites. Fournier’s gangrene, a rapidly progressive, often fatal, necrotizing fasciitis of the external genitalia and perineum due to Salmonella Typhimurium, is a
rare manifestation and has never been reported.

Case:
A 22-year-old male, apparently healthy patient with no relevant past medical history presented to surgical emergency
with chief complaints of swelling of bilateral scrotal area. Infective etiology was considered and a diagnosis of fournier’s
gangrene was made. Pure growth of Salmonella Typhimurium was obtained after repeated subculture and was identified biochemically and on serotyping, as Salmonella enterica serotype Typhimurium using specific antisera.

Conclusion:
In our case report, we describe a case of fournier’s gangrene due to Salmonella Typhimurium in an otherwise
healthy male to highlight the unusual presentation of Non typhoidal salmonellae at an aberrant site. We also emphasize the
importance of using selective media like Selenite F broth for isolation of Salmonella Typhimurium from a pus sample.
Psychological and Mental Health Issues During the SARS-CoV-2 Global Pandemic: A Critical Analysis
Authors: Khan Tahmeena , Azad Iqbal , Lawrence Alfred J. 
Published: November 2020

Introduction:
With the outbreak of the SARS-CoV-2 in Wuhan, China in December,
2019, presently over 200 countries have been facing gruesome health effects of the deadly virus,
with cases and casualties on the rise. So far, no concrete medicinal drug or vaccine has been developed
to check the lethal viral infection, henceforth authorities have emphasized on practicing social
distancing and imposed strict lockdowns forcing people to confine in their homes.

Material and Methods:
This review was aimed to analyze the effects on mental health and well being
during the pandemic. The studies cited in the review were sourced from journals, books and digital
media reports. The research papers indexed in databases such as PUBMED, SCOPUS, INDEX
COPERNICUS, CHEMICAL AND BIOLOGICAL ABSTRACTS, MEDLINE, EMBASE, EBSCO,
DOAJ and THOMSON REUTERS were reviewed and have been included in the review.

Results:
The coronavirus mayhem has not only posed a threat to human health, but also jolted different
aspects of society, including mental and psychological health. Loss of freedom, boredom,
fear and angst are some of the mild psychological effects, whereas a rise in domestic violence and
suicidal tendencies is the more serious consequence reported from different parts of the world during
the lockdown period.

Conclusion:
This article is a comprehensive analysis of the effects on mental and psychological
well being during this critical time. Strategic measures to be adopted by individuals and administration
to cope up with the situation are also suggested as it should be an immediate priority to address
the overall distress caused by the pandemic in public.
responsabilidad penal de la persona jurídica y la aplicación de la figura del compliance en las compañías ecuatorianas
Authors: Bautista Chilla Alfonso Andrés 
Published: November 2020

En la legislación penal y societaria del Ecuador, al momento no existe una figura efectiva de prevención de la responsabilidad penal de las compañías, o que atenúe o las exima de dicha responsabilidad. En atención a esta necesidad, se debe incluir la figura del Compliance en el Código Orgánico Integral Penal y en la Ley de Compañías, a través de una reforma legal. Para este trabajo se realizó una revisión de los criterios de diferentes juristas que guardan relación con el tema planteado; además en se emplearon métodos de investigación propios de la ciencia del Derecho, tales como el documental que permitió analizar la sentencia española 154/2016 acerca de la responsabilidad penal de la persona jurídica y la aplicación de medidas de prevención; además se empleó el método empírico, en tal sentido, como muestra, se obtuvo la opinión de la Intendenta Nacional de Procuraduría y Asesoría Institucional encargada de la Superintendencia de Compañías, Valores y Seguros, doctora Elena Paola Pinoargote Vásquez, quien posee aproximadamente 20 años de experiencia dentro del ámbito societario; de lo revisado a los largo del proyecto se pudo determinar que es viable aplicar la figura del Compliance en las compañías ecuatorianas.