bluuebunny/crossref_metadata_2025_split huggingface dataset:
High risk of septic complications following surgery for Crohn's disease in patients with preoperative anaemia, hypoalbuminemia and high CRP
Authors: Ghoneima Ahmed S. , Flashman Karen , Dawe Victoria , Baldwin Eleanor , Celentano Valerio 
Published: November 2019

Abstract

Aim
Bowel resection in Crohn's disease still has a high rate of complications due to risk factors including immune suppression, malnutrition and active inflammation or infection at the time of operating. In this study, we use serological levels and inflammatory markers to predict the potential of complications in patients undergoing resections for complicated Crohn's disease.

Methods
All patients undergoing laparoscopic bowel resection for Crohn’s disease from 5th of November 2012 to 11th of October 2017 were included in this retrospective observational study. Patients were divided into 4 groups scoring 0, 1, 2 or 3 depending on their pre-operative haemoglobin concentration (Hb), C-reactive protein (CRP) and albumin (Alb) where 1 point was given for an abnormal value in each as detailed in the definitions. They were then grouped into a low risk group comprised of those scoring 0 and 1, and a high risk group for those scoring 2 and 3 and data was collected to compare outcomes and the incidence of septic complications.

Results
Seventy-nine patients were included. Eleven (13.9%) and 2 (2.5%) patients had 2 or 3 abnormal values of CRP, Alb and Hb and were categorized as high risk. High risk patients had a significantly higher rate of post-operative septic complications (30.7%) compared with low risk patients (10.6%) p value < 0.0001.

Conclusion
Pre-operative CRP, haemoglobin and albumin can serve as predictors of septic complications after surgery for Crohn’s disease and can therefore be used to guide pre-operative optimisation and clinical decision-making.
Autophagy as a consequence of seasonal functions of testis and epididymis in adult male European bison (Bison bonasus, Linnaeus 1758)
Authors: Tabecka-Lonczynska Anna , Mytych Jennifer , Solek Przemyslaw , Koziorowski Marek 
Published: November 2019

AbstractThe European bison is still an animal endangered with extinction, so by learning factors that regulate its reproduction, we can contribute to the survival of this species. On the other hand, autophagy is a dynamic, lisosomal, and evolutionary conserved process which is essential for animal cell survival, homeostasis, and differentiation. This process was demonstrated in many species and in many organs; however, information on the metabolic course of autophagy in the male reproductive system in seasonally reproducing species is lacking. Therefore, in this study, we examined for the first time several autophagy-related factors (mTOR, ULK1, Atg13, PI3K, beclin1, beclin2, Atg14, Atg5, Atg16L, LC3) in testicular and epididymal tissues obtained from adult male individuals of the European bison. We compared the level of gene expression, protein synthesis, and localization of autophagy-related factors between June, September, and December (before, during, and after reproductive activity, respectively). We confirmed that the induction of autophagy was at the highest level in the period after reproductive activity, i.e., in December, when a significant increase in the gene and protein expression was observed for the majority of these factors, probably to ensure cellular protection. However, autophagy was also clearly marked in September, during the intense spermatogenesis, and this may indicate a great demand for autophagy-related proteins required for the normal development of reproductive cells. Obtained results seem to confirm that autophagy pathway, as a consequence of seasonal reproduction, may control the normal course of spermatogenesis in the male European bison.
Nonlinear dynamic behaviour of severely corroded reinforced concrete columns: shaking table study
Authors: Ge Xiao , Dietz Matthew S. , Alexander Nicholas A. , Kashani Mohammad M. 
Published: November 2019

Abstract
A set of benchmark, medium scale, shaking table tests on corroded reinforced concrete (RC) columns is conducted with the aim of investigating the effects of corrosion damage on the nonlinear dynamic behaviour of RC bridge piers. The experimental programme consists of an uncorroded control specimen and two corroded RC column specimens, with identical structural details. An accelerated corrosion procedure is used to corrode the RC columns. The uncorroded and corroded specimens are subjected to far-field long duration ground motion excitations. The two corroded columns had 51% and 65% average mass loss ratios. The testing sequence includes slight, extensive, and complete damage levels, followed by an aftershock to examine the cascade effect on the nonlinear dynamic response of the proposed RC columns. The experimental results show that corrosion changes the failure mode of the RC columns, and has a significant negative impact on the residual strength (about 50% mass loss results in about 80% strength reduction) and drift capacity of RC columns.
Hidden Object Detection and Recognition in Passive Terahertz and Mid-wavelength Infrared
Authors: Kowalski M. 
Published: November 2019

Abstract
The study presents the comparison of detection and recognition of concealed objects covered with various types of clothing by using passive imagers operating in a terahertz (THz) range at 1.2 mm (250 GHz) and a mid-wavelength infrared (MWIR) at 3–6 μm (50–100 THz). During this study, large dataset of images presenting various items covered with various types of clothing has been collected. The detection and classification algorithms aimed to operate robustly at high processing speed across these two spectrums. Properties of both spectrums, theoretical limitations, performance of imagers and physical properties of fabrics in both spectral domains are described. The paper presents a comparison of two deep learning–based processing methods. The comparison of the original results of various experiments for the two spectrums is presented.
Extended Modal Realism — a New Solution to the Problem of Intentional Inexistence
Authors: Thomas Andrew D. 
Published: November 2019

AbstractKriegel described the problem of intentional inexistence as one of the ‘perennial problems of philosophy’ (KriegelPhilosophical Perspectives21(1), 307–340, 2007: 307). In the same paper, Kriegel alluded to a modal realist solution to the problem of intentional inexistence. However, Kriegel does not state by name who defends the kind of modal realist solution he has in mind. Kriegel also points out that even what he believes to be the strongest version of modal realism does not pass the ‘principle of representation’ and thus modal realism is not an adequate solution to the problem of intentional inexistence. In this paper, I respond to Kriegel by defending a modal realist solution that he did not consider in 2007, called ‘extended modal realism’ (EMR). EMR is a version of modal realism where possible worlds are not completely isolated as they are under the Lewisian model. Rather, under EMR worlds are, in a way, spatiotemporally related. The fact EMR worlds are related allows EMR to sufficiently pass the principle of representation and thus can be deemed a legitimate solution to the problem of intentional inexistence. I conclude that either EMR can pass the principle of representation in some cases or, and I think the more sensible option, we give up on the principle of representation altogether.
Molecular profiling in gastroesophageal cancer—clinical routine and future perspective
Authors: Puhr Hannah Christina , Ilhan-Mutlu Aysegül 
Published: November 2019

SummaryAlthough several large clinical trials have been conducted in order to investigate targeted inhibition of several molecular pathways in gastric cancer, only a limited number of targeted therapies have been introduced in clinical routine. Besides scientific interest, international guidelines recommend investigation of some distinct molecular alterations, which are associated with therapeutic consequences. These are (i) human epidermal growth factor receptor 2 (HER2), (ii) programmed death receptor 1 (PD-L1) and (iii) microsatellite instability (MSI). There are some emerging markers, such as Epstein–Barr virus (EBV), which might also be associated with a favorable response to immunotherapy. These routine and potential markers will be further discussed in the scope of this short review.
Nutrition behaviour and compliance with the Mediterranean diet pyramid recommendations: an Italian survey-based study
Authors: Bracale Renata , Vaccaro Concetta M. , Coletta Vittoria , Cricelli Claudio , Gamaleri Francesco Carlo , Parazzini Fabio , Carruba Michele 
Published: November 2019

Abstract

Purpose
Adopting a Mediterranean-like dietary pattern may help in preventing several chronic diseases. We assessed the eating behaviour and compliance with the Mediterranean diet pyramid recommendations in Italy.

Methods
This is a cross-sectional study conducted in subjects aged ≥ 20 years. A 14-question survey based on the updated Mediterranean diet pyramid was launched online from April 2015 to November 2016. At test completion, a personalized pyramid displaying the possible deficiencies and/or excesses was generated, that could be the basis to plan diet and lifestyle modifications.

Results
Overall, 27,540 subjects completed the survey: the proportion of females (75.6%), younger subjects (20.7%) and people with a University degree (33.1%) resembled those of the Italian population of Internet users rather than of the general population. 37.8% of participants declared a sedentary lifestyle, including 29.6% of those aged 20–29 years. A lower-than-recommended intake of all food categories included in the Mediterranean diet pyramid, along with excess of sweets, red and processed meats, emerged, that may affect health in the long term. Low adherence to recommendations was observed especially among females and older people. Notably, a discrepancy surfaced between the responders’ perceived and actual behaviour toward the regular consumption of fruits and vegetables (81.8% vs 22.7–32.8%, respectively).

Conclusions
The nutritional habits and lifestyle of Italian participants are poorly adherent to the Mediterranean diet recommendations. The personalized pyramid tool may help in raising the awareness of individuals and their families on where to intervene, possibly with the support of healthcare professionals, to improve their behaviour.

Level of evidence
Level V, cross-sectional descriptive study.
5G device-to-device communication security and multipath routing solutions
Authors: Celik Aslihan , Tetzner Jessica , Sinha Koushik , Matta John 
Published: November 2019

Abstract
Through direct communication, device-to-device (D2D) technology can increase the overall throughput, enhance the coverage, and reduce the power consumption of cellular communications. Security will be of paramount importance in 5G, because 5G devices will directly affect our safety, such as by steering self-driving vehicles and controlling health care applications. 5G will be supporting millions of existing devices without adequate built-in security, as well as new devices whose extreme computing power will make them attractive targets for hackers.This paper presents a survey of the literature on security problems relating to D2D communications in mobile 5G networks. Issues include eavesdropping, jamming, primary user emulation attack, and injecting attack. Because multipath routing emerges as a strategy that can help combat many security problems, particularly eavesdropping, the paper contains an extensive discussion of the security implications of multipath routing. Finally, the paper describes results of a simulation that tests three path selection techniques inspired by the literature. The simulation reveals that routing information through interference disjoint paths most effectively inhibits eavesdropping.
Impact of a Central-Line Insertion Site Assessment (CLISA) score on localized insertion site infection to prevent central-line–associated bloodstream infection (CLABSI)
Authors: Gohil Shruti K. , Yim Jennifer , Quan Kathleen , Espinoza Maurice , Thompson Deborah J. , Kong Allen P. , Bahadori Bardia , Tjoa Tom , Paiji Chris , Rudkin Scott , Rashid Syma , Hong Suzie S. , Dickey Linda , Alsharif Mohamad N. , Wilson William C. , Amin Alpesh N. , Chang Justin , Khusbu Usme , Huang Susan S. 
Published: November 2019

AbstractObjective:To assess the impact of a newly developed Central-Line Insertion Site Assessment (CLISA) score on the incidence of local inflammation or infection for CLABSI prevention.Design:A pre- and postintervention, quasi-experimental quality improvement study.Setting and participants:Adult inpatients with central venous catheters (CVCs) hospitalized in an intensive care unit or oncology ward at a large academic medical center.Methods:We evaluated CLISA score impact on insertion site inflammation and infection (CLISA score of 2 or 3) incidence in the baseline period (June 2014–January 2015) and the intervention period (April 2015–October 2017) using interrupted times series and generalized linear mixed-effects multivariable analyses. These were run separately for days-to-line removal from identification of a CLISA score of 2 or 3. CLISA score interrater reliability and photo quiz results were evaluated.Results:Among 6,957 CVCs assessed 40,846 times, percentage of lines with CLISA score of 2 or 3 in the baseline and intervention periods decreased by 78.2% (from 22.0% to 4.7%), with a significant immediate decrease in the time-series analysis (P < .001). According to the multivariable regression, the intervention was associated with lower percentage of lines with a CLISA score of 2 or 3, after adjusting for age, gender, CVC body location, and hospital unit (odds ratio, 0.15; 95% confidence interval, 0.06–0.34; P < .001). According to the multivariate regression, days to removal of lines with CLISA score of 2 or 3 was 3.19 days faster after the intervention (P < .001). Also, line dwell time decreased 37.1% from a mean of 14 days (standard deviation [SD], 10.6) to 8.8 days (SD, 9.0) (P < .001). Device utilization ratios decreased 9% from 0.64 (SD, 0.08) to 0.58 (SD, 0.06) (P = .039).Conclusions:The CLISA score creates a common language for assessing line infection risk and successfully promotes high compliance with best practices in timely line removal.
Text2Quit: an analysis of user experiences with a mobile smoking cessation program
Authors: Abroms L. C. , Heminger C. L. , Boal A. L. , Van Alstyne J. M. , Krishnan N. 
Published: November 2019

AbstractIntroductionStudies have shown that Text2Quit and other mobile cessation programs increase quit rates in adult smokers, but the mechanism of effects and user experiences are not well understood.AimsThis study reports on participants' experiences with the program and explores aspects of the program that they liked and disliked.MethodsSelf-reported experiences of the program were collected through a follow-up survey conducted 1 month after enrollment (n = 185). Participant responses to open-ended items were dual coded by independent coders.ResultsOverall participants agreed that they liked the program (4.2/5), that the program was helpful (4.1/5) and that they would recommend the program to a friend (4.3/5). Top reasons for liking the program included that it served as a constant reminder of quitting (17.8%), the content (16.7%), the encouragement provided (13.3%), and the on-demand tools (12.2%). Top reasons for disliking the program were message frequency (20.5%), content (7.0%), and the lack of personal interaction (7.0%).ConclusionsThe constancy of messaging was both liked as a reminder and disliked as an annoyance. Future programs might be improved by pre-testing and customizing the content based on user preferences, and by adding in human interactions, while keeping a supportive tone and offering on-demand tools.
Cyclospora cayetanensis infection in humans: biological characteristics, clinical features, epidemiology, detection method and treatment
Authors: Li Junqiang , Wang Rongjun , Chen Yuancai , Xiao Lihua , Zhang Longxian 
Published: November 2019

AbstractCyclospora cayetanensis, a coccidian parasite that causes protracted and relapsing gastroenteritis, has a short recorded history. At least 54 countries have documented C. cayetanensis infections and 13 of them have recorded cyclosporiasis outbreaks. Cyclospora cayetanensis infections are commonly reported in developing countries with low-socioeconomic levels or in endemic areas, although large outbreaks have also been documented in developed countries. The overall C. cayetanensis prevalence in humans worldwide is 3.55%. Among susceptible populations, the highest prevalence has been documented in immunocompetent individuals with diarrhea. Infections are markedly seasonal, occurring in the rainy season or summer. Cyclospora cayetanensis or Cyclospora-like organisms have also been detected in food, water, soil and some other animals. Detection methods based on oocyst morphology, staining and molecular testing have been developed. Treatment with trimethoprim–sulfamethoxazole (TMP–SMX) effectively cures C. cayetanensis infection, whereas ciprofloxacin is less effective than TMP–SMX, but is suitable for patients who cannot tolerate co-trimoxazole. Here, we review the biological characteristics, clinical features, epidemiology, detection methods and treatment of C. cayetanensis in humans, and assess some risk factors for infection with this pathogen.
A psychometric evaluation of the Family Decision-Making Self-Efficacy Scale among surrogate decision-makers of the critically ill
Authors: Pignatiello Grant A. , Irani Elliane , Tahir Sadia , Tsivitse Emily , Hickman Ronald L. 
Published: November 2019

AbstractObjectivesThe purpose of this study was to report the psychometric properties, in terms of validity and reliability, of the Unconscious Version of the Family Decision-Making Self-Efficacy Scale (FDMSE).MethodsA convenience sample of 215 surrogate decision-makers for critically ill patients undergoing mechanical ventilation was recruited from four intensive care units at a tertiary hospital. Cross-sectional data were collected from participants between days 3 and 7 of a decisionally impaired patient's exposure to acute mechanical ventilation. Participants completed a self-report demographic form and subjective measures of family decision-making self-efficacy, preparation for decision-making, and decisional fatigue. Exploratory factor analyses, correlation coefficients, and internal consistency reliability estimates were computed to evaluate the FDMSE's validity and reliability in surrogate decision-makers of critically ill patients.ResultsThe exploratory factor analyses revealed a two-factor, 11-item version of the FDMSE was the most parsimonious in this sample. Furthermore, modified 11-item FDMSE demonstrated discriminant validity with the measures of fatigue and preparation for decision-making and demonstrated acceptable internal consistency reliability estimates.Significance of resultsThis is the first known study to provide evidence for a two-factor structure for a modified, 11-item FDMSE. These dimensions represent treatment and palliation-related domains of family decision-making self-efficacy. The modified FDMSE is a valid and reliable instrument that can be used to measure family decision-making self-efficacy among surrogate decision-makers of the critically ill.
The Potential of Flight: U.S. Aviation and Pan-Americanism During the Early Twentieth Century
Authors: Bryne Alex 
Published: November 2019

AbstractThis article examines the formative years of flight in the United States and argues that Pan-Americanism served as a guiding ideology in the development of the nation's early aeronautic endeavors. With the advent of the airplane at the turn of the twentieth century, U.S. Pan-Americanists believed that aviation would provide a solution to the sociological and practical problems that hindered the development of international unity among the American republics. By physically transporting individuals, products, and cultural media rapidly across the hemisphere via the sky, aircraft would unite the peoples of Latin America and the United States and promote inter-American cooperation. To see the Pan-American potential of aircraft fulfilled, Pan-Americanists cooperated with private U.S. aviation organizations to expound the value of flight and to generate interest in aviation across the Western Hemisphere. Although a variety of Pan-American initiatives were successfully undertaken during the 1910s, the outbreak of the First World War hindered the movement and ultimately led to the transformation of aviation into a tool of U.S. imperialism in Latin America. By examining the origins of U.S. aviation through the lens of Pan-Americanism, this article seeks to reevaluate the pervading imperial narrative of the history of U.S. aviation in the Western Hemisphere.
Effect of processing conditions on the stability of native vitamin A and fortified retinol acetate in milk
Authors: Sachdeva Bhawana , Kaushik Ravinder , Arora Sumit , Khan Azhar 
Published: November 2019

Abstract. The objective of this investigation was to evaluate the stability of vitamin A in fortified milk which was exposed to different processing conditions viz. heat treatments (pasteurization, boiling and sterilization), light exposure treatments (1485, 2970 and 4455 lux for 2, 4, 8, 16 and 32 h) and different packaging materials (polyethylene pouches and glass bottles) and also to evaluate the effect of fortified iron (ferric pyrophosphate soluble (FPP) and ferrous gluconate hydrate (FG) on vitamin A stability during processing and storage. Toned milk was fortified with 25 ppm iron and vitamin A acetate 2500 IU/L, singly and also in combination. The vitamin A analysis method was optimized and accuracy and precision were below ± 5%. The results indicated that vitamin A was heat-labile and its degradation increased with the increase in the intensity of heat treatments. Pasteurized milk (318.11 IU/L) showed non-significant (p > 0.05) decrease, however, boiling (250.21 IU/L) and sterilization (205.65 IU/L) showed a significant difference (p < 0.05) in vitamin A content in comparison to control (324.71 IU/L). Similarly, vitamin A was light sensitive and its degradation significantly increased (p < 0.05) with an increase in the intensity of light exposure (34.82 to 92.53%). Loss of vitamin A (%) was significantly greater (p < 0.05) in iron-fortified milk suggesting that iron might have played a role in accelerating the degradation of vitamin A. Extent of losses were significantly higher (p < 0.05) in FG compared to FPP fortified milk. Vitamin A (microencapsulated form) which was added externally was more stable than the inherent vitamin A present in milk.