bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of vascular invasion with lymph node metastasis as a prognostic factor in stage I-III colon cancer: an observational cohort study
Authors: Bae Jung Hoon , Lee Chul Seung , Han Seung-Rim , Kim Ji Hoon , Kye Bong-Hyeon , Lee In Kyu , Lee Yoon Suk 
Published: July 2020

Abstract
Background: The oncological impact of vascular invasion (VI), when compared with that of lymph node metastasis (LNM), has been underestimated in clinicopathological staging of colon cancer. This study aimed to evaluate the prognostic impact of VI in comparison with that of LNM in non-metastatic colon cancer.Methods: Patients who underwent surgery for stage I-III colon cancer were divided into four groups depending on the status of VI and LNM (Group I: VI-/LNM-; Group II: VI+/LNM-; Group III: VI-/LNM+; Group IV: VI+/LNM+). Group III was subdivided according to the node (N) stage (Group IIIA: VI-/N1; Group IIIB: VI-/N2). Disease-free survival (DFS) and overall survival were compared.Results: In total, 793 non-metastatic colon cancer patients were included. Group II (hazard ratio [HR] 2.34, 1.01-5.41), Group III (HR 1.91, 1.26-2.89), and Group IV (HR 2.34, 1.33-4.14) were independently associated with poor DFS. All recurrences in Group II occurred within 2 years and were distant metastases. The 1- and 2-year DFS rates were 76.3% and 71.6% in Group II and 88.3% and 79.8% in Group III, respectively (P = 0.067 and 0.247). In subgroup analysis, the 5-year DFS rates tended to be lower in Group II (71.6%) than in Group IIIA (79.7%) and higher than those in Group IIIB (61.4%).Conclusion: VI is a prognostic factor as significant as LNM and may be regarded as a stronger prognostic factor than N1 stage in non-metastatic colon cancer. Furthermore, a potential association was observed between VI and recurrence patterns, such as early recurrence and distant metastasis.
Screening and Treating Malaria in Pregnancy by Community Health Workers in Benin, Burkina Faso and Gambia: Profiles, Perceptions and Time Commitments
Authors: Duval Laetitia , Sicuri Elisa , Scott Susana , Traoré Maminata , Tinto Halidou , Grietens Koen Peeters , d’Alessando Umberto , Nahum Alain , Schallig Henk , Mens Petra , Conteh Lesong 
Published: July 2020

Abstract
Background

To date, there have been few studies on the roles and challenges that community health workers (CHWs) face when encouraging pregnant women to attend health facilities and provide community-based interventions including scheduled screening and treatment (CSST) for malaria. This study investigates the characteristics, daily activities and time commitments of CHWs tasked with delivering CSST as part of a cluster-randomized controlled trial in Benin, Burkina Faso and Gambia.
Methods

45 CHWs were interviewed and observed in three rural settings in West Africa, both during and outside the malaria transmission seasons.
Results

CHWs in all three settings were predominantly male, over 30 years old and relied on farming for income. Most had completed secondary school in Benin (77%) but not in Burkina Faso (33%) or The Gambia (27%). In Benin, most had been in post between 5 to 10 years; in Burkina Faso and The Gambia the majority had been CHWs for over 10 years. CHWs in Burkina Faso received the highest monthly financial reward for taking part in the trial (US$40), next was Benin (US$22.60) and finally Gambian CHWs received US$11. While the CHWs welcomed the increased training, knowledge and skills they acquired on screening and treating malaria in pregnancy afforded by the trial, they also expressed concern about the transportation challenges of successful community-based interventions in remote areas. CHW duties were a bigger time commitment in Burkina Faso than Benin. The time committed to CHW activities (trial and non-trial) was longer during than outside the malaria transmission season.
Conclusions

This study highlights the importance of taking into account the variety of existing CHW responsibilities when designing and implementing evidence-based policy to address malaria in pregnancy. The findings emphasise the need to consider both financial and non-financial factors likely to impact the scale-up and sustainability of interventions beyond trial conditions.
The Way a General Hospital Treated COVID-19 in Shenzhen, China &amp; the Epidemiological and Clinical Characteristics of its Confirmed Patients
Authors: Zhou Yang , Yang Le , Tang Quanzhen , Ruan Zhongrui , Huang Minqiang , Han Ming , Han Wei , Lu Jian 
Published: July 2020

Abstract
Objectives: To discuss the prevention and containment of COVID-19 at a general hospital in Shenzhen China; to analyze the epidemiological and clinical characteristics of its confirmed patients, which is intended to provide a model for other hospitals in COVID-19 management.Methods: The General Hospital of Shenzhen University sets up 4 medical zones relative to the COVID-19 prevention and containment. In so doing, the suspected patients classified into different kind of ward receive different treatment (Classified and Separated Treatment). The epidemiological distribution and clinical characteristics of 28 confirmed cases in the hospital were analyzed.Results: There are no medical personnel infected cases, no cross-infection among the patients in the hospital, and no misdiagnosis or missed diagnosis of COVID-19. The majority of cases in the group is from 15 to 60 years old, 25 cases had a definite travel history or close contact history in the epidemic area, and parents and spouses of the confirmed patients are the main contact groups. Fever and respiratory symptoms have a high proportion, 4 diarrhea and 4 asymptomatic cases. Additionally, the decrease of lymphocyte is observed in 8 cases. Chest CT scan shows viral pneumonia in 14 cases，All patients were confirmed by nucleic acid tests.Conclusions: Classified and Separated Treatment facilitates management of COVID-19 in the general hospital. Relative to suspected patients in the general hospital, diagnosis matters more than treatment. Epidemiological history, lymphocyte count, and chest CT scan play an important role as the indicator in early diagnosis of COVID-19.
A systematic review protocol of medical and clinical research landscapes and quality in Malaysia and Indonesia [REALQUAMI]
Authors: Chew Boon How , Lee Shaun Wen Huey , Lim Poh Ying , Teoh Soo Huat , Rashid Aneesa Abdul , Devaraj Navin Kumar , Daud Adibah Hanim Ismail @ , Manap Abdul Hadi Abdul , Mohamad Fadzilah , Fernandez Aaron , Ali Hanifatiyah , Kassim Puteri Shanaz Jahn , Shamsuddin Nurainul Hana , Zakuan Noraina Muhamad , Abdullah Akiza Roswati , Widyahening Indah S. 
Published: July 2020

Abstract
Background

Research landscapes and quality may change in many ways. Much research waste has been increasingly reported. Poorly conducted clinical and biomedical researches are detrimental to the health of the people and healthcare performance with misleading clinical evidence. Efforts to improve research performance will need good data on the profiles and performance of past research. This systematic review aims to describe the characteristics and examine the quality of clinical and biomedical research in Malaysia and Indonesia.
Methods

A search will be conducted in PubMed, EMBASE, CINAHL and PsycINFO to identify for published clinical and biomedical research from 1962 to 2019 from Malaysia and/or Indonesia. Additional search will also be conducted in MyMedR (Malaysian only). Studies found will be independently screened by a team of reviewers, relevant information will be extracted and the quality of articles will be assessed. In Phase 1, the characteristics of the research including the profiles of the researchers and the journals in which they are published will be reported descriptively. In Phase 2, a research quality screening tool will be validated to assess the research quality based on three domains of relevance, the credibility of the methods and usefulness of the results. Associations between the research characteristics and quality will be analysed. The independent effect of each of the determinant will be quantified in multivariable regression analysis. Longitudinal trends of the research characteristics, health conditions studied and settings, among others will be explored.
Discussion

Results of this study will serve as the 'baseline' data for future evaluation and within the country and between countries comparison. This review may also provide informative results to stakeholders of the evolution of research conduct and performance from the past until now. The longitudinal and prospective trends of the research characteristics and quality could provide suggestions on improvement initiatives. Additionally, information on health conditions, research settings, and whether they are over- or under-studied may help future prioritization of research initiatives and resources.
Registration:
CRD42020152907 (PROSPERO) and https://osf.io/w85ce (Open Science Framework’s registry for Research on the Responsible Conduct of Research).
ЗМІНИ ПСИХО-ЕМОЦІЙНОГО СТАНУ ТА ФУНКЦІОНАЛЬНИХ МОЖЛИВОСТЕЙ ПЕРЕДПЛІЧЧЯ ТА ЗАП’ЯСТКА ЯК МАРКЕР ЕФЕКТИВНОСТІ ФІЗИЧНОЇ ТЕРАПІЇ ПАЦІЄНТІВ З ПОСТІММОБІЛІЗАЦІЙНИМИ КОНТРАКТУРАМИ ВНАСЛІДОК ПЕРЕЛОМІВ ДИСТАЛЬНИХ ВІДДІЛІВ КІСТОК ПЕРЕДПЛІЧЧЯ
Authors: Бирчак В. М. , Дума З. В. , Аравіцька М. Г. 
Published: July 2020

Резюме. Цілі: визначення ефективності розробленої програми фізичної терапії за результатами функціонування передпліччя та зап’ястка у хворих з постіммобілізаційними контрактурами променево-зап’ясткового суглоба (ПЗС).
Методи. Обстежено 56 осіб з постіммобілізаційною контрактурою ПЗС. Їх було поділено на дві групи: порівняння (займались згідно з принципами поліклінічної реабілітації) та контрольну (займались за розробленою програмою фізичної терапії – комбінація теплого вологого компресу в поєднанні з постізометричною релаксацією м’язів; масаж; функціональне тренування із застосуванням китичних тренажерів та еспандерів; лікування положенням за допомогою динамічних ортезів; кінезіологічне тейпування). Ефективність програми оцінювали порівнянням стану здорової та травмованої рук за результатами гоніометрії, мануального м’язового тестування, а також стандартних опитувальників АBILIHAND, DASH, HADS.
Результати. Після реабілітаційного втручання виявлено нормалізацію рухів ПЗС у пацієнтів основної групи за результатами гоніометрії та за результатами мануального м’язового тестування на відміну від пацієнтів групи порівняння (р<0,05). Результати тестування за опитувальником АBILIHAND показали покращення в групі порівняння на 46,49%, в основній – на 65,88%. За опитувальником DASH пацієнти групи порівняння досягли рівня функціонування руки «хороший», основної групи – «відмінний». Інтенсивність ступеня психо-емоційної напруги за обома шкалами HADS в групі порівняння зменшились до субклінічного рівня, в основній – досягла норми.
Висновки. Розроблена комплексна програма фізичної терапії виявила статистично значуще кращий вплив на показники психо-емоційного стану та функціональних можливостей передпліччя та зап’ястка в порівнянні з поліклінічною реабілітаційною програмою.
CHARACTERIZATION OF SCAFFOLDING BASED ON THE STUDENTS’ THINKING ERROR IN SOLVING MATHEMATIC PROBLEM
Authors: Prayitno Anton , Nurjana Efi Fatma , Khasanah Fitria 
Published: July 2020

This study was aimed at identifying the thinking error of the students in solving mathematics problems and providing the scaffolding. The study was descriptive explorative. This study was conducted in Mojokerto.The subjects were 25 students, however, only 3 were described since the scaffolding used was of level 2. Data were collected initially by asking the subjects to solve mathematic test items. Error patterns were identified from the students’ works. The students who made errors were chosen as the research subjects. Findings show that there were differences in the students’ thinking patterns before and during the provision of scaffolding. These differences occur due to the different scaffolding treatments according to the thinking errors. For students who have difficulties in understanding problems, the scaffolding is in the form of leading questions. For those who have difficulties in connecting previous concepts, the scaffolding is in the form of drawing tables and recalling previous materials. For students who have difficulties in organizing a strategy, the scaffolding is in the form of recalling the strategy that has been plannedKARAKTERISASI SCAFFOLDING BERDASARKAN KESALAHAN BERPIKIR SISWA DALAM MENYELESAIKAN MASALAH MATEMATIKA Penelitian ini bertujuan untuk mengidentifikasi kesalahan berpikir siswa dalam menyelesaikan masalah matematika dan pemberian scaffolding. Penelitian menggunakan metode deskriptif eksploratif. Penelitian dilakukan di beberapa sekolah di Kota Mojokerto. Subjek penelitian ini berjumlah 25 orang, namun yang dipaparkan pada artikel hanya 3 dengan scaffolding level 2. Prosedur pengumpulan data diawali dengan siswa diminta untuk menyelesaikan masalah matematika. Selanjutnya, hasil pekerjaan tersebut diidentifikasi pola kesalahannya. Siswa yang menghasilkan pekerjaan salah, dijadikan subjek penelitian. Hasil penelitian menunjukkan adanya perbedaan berpikir siswa sebelum pemberian scaffolding dan selama pemberian scaffolding. Perbedaan terjadi karena peneliti memberikan scaffolding sesuai jenis kesalahan berpikir yang dialami siswa. Ketika subjek mengalami kesulitan dalam memahami masalah, scaffolding yang diberikan berupa pertanyaan arahan. Apabila subjek mengalami kesulitan dalam menghubungkan dengan konsep terdahulu, scaffolding berupa petunjuk untuk membuat tabel dan mengingat kembali materi yang telah dipelajari. Untuk subjek yang mengalami kesulitan dalam menyusun strategi, scaffolding berupa dorongan untuk mengingat kembali strategi yang sudah direncanakan
DEVELOPING AN ENTREPRENEURSHIP-LOADED PRODUCTIVE LEARNING MODEL
Authors: Jaedun Amat , Hariyanto V. Lilik , Raharjo Nuryadin Eko 
Published: July 2020

This study was aimed at obtaining a pratical and effective Entrepreneurship-Loaded Productive Learning model (ELPL model) for graduates of the building construction department of the vocational schools to become entrepreneurs of their expertises as technopreneurs. The study was research and development, focused on developing ELPL model. It was done through the following phases: review of the existing models, needs assessment for model development; third, evaluation of model implementability, revision of the ELPL draft, and limited try-out of the ELPL model in Grade XII of the Wood Construction of Vocational School 2, Pengasih, Kulon Progo. Findings show that the ELPL model is implementable for learning, practical, and effective to develop the entrepreneurship skills of the XII grade students in the Wood Construction Subjects at SMK 2 Pengasih, related to their expertise as technopreneurs. PPBK model is feasible to use in teaching and learning processPENGEMBANGAN MODEL PEMBELAJARAN PRODUKTIF BERMUATAN KEWIRAUSAHAANPenelitian ini bertujuan untuk mengembangkan model pembelajaran kemampuan produktif bermuatan kewirausahaan (model PPBK) yang efektif dalam membekali lulusan SMK Program Keahlian Teknik Bangunan untuk menjadi wirausahawan sesuai dengan bidang keahliannya sebagai technopreneur. Penelitian ini merupakan jenis penelitian pengembangan (Research & Development). Penelitian berorientasi pada pengembangan produk yaitu model PPBK. Penelitian dilakukan melalui lima tahapan yaitu: kajian model pembelajaran kemampuan produktif yang telah dilaksanakan, asesmen kebutuhan pengembangan model, penilaian keterlaksanaan model, revisi draf model PPBK, dan uji coba model PPBK. Uji coba model dilakukan secara terbatas pada Kelas XII Paket Keahlian Teknik Konstruksi Kayu di SMK Negeri 2 Pengasih, Kulon Progo. Hasil penelitian menunjukkan bahwa model PPBK yang dikembangkan terbukti dapat diimplementasikan dalam pembelajaran. Model PPBK praktis dan efektif untuk memberikan bekal kemampuan berwirausaha bagi siswa SMK Kelas XII Paket Keahlian Teknik Konstruksi Kayu di SMK Negeri 2 Pengasih sesuai dengan bidang keahliannya sebagai technopreneur. Perangkat pembelajaran PPBK yang dikembangkan layak diimplementasikan
IMPLEMENTATION OF SAFETY EDUCATION IN THE SPORT CLASS
Authors: Sukarmin Yustinus , Sumaryanti Sumaryanti 
Published: July 2020

This study was aimed at finding out the significance of safety education implemented the physical education teachers of the lower grade of the elementary school during the teaching-learning process. The study was is descriptive qualitative with one variable, namely implementation of safety education. The research subjects were 1,368 physical education teachers of state elementary schools in the Special Region of Yogyakarta, selected by cluster random sampling of 200 teachers from each school. The study was a survey using questionnaires to collect data. Data analysis was descriptive quantitative using percentages. Findings show that safety education implemented by the lower grade of elementary school physical education teachers is described as follows. First, in the fair category in general = 82.69%, in the environmental aspect = 78.92%, in the student aspect = 81.94 %), and in the weather aspect = 73.65%. Second, in the good caregory, in the human aspect = 86.46% and in the teacher aspect = 90.99%IMPLEMENTASI PENDIDIKAN KESELAMATAN DALAM PEMBELAJARAN OLAHRAGAPenelitian ini bertujuan untuk mengetahui implementasi pendidikan keselamatan oleh guru Pendidikan Jasmani Olahraga dan Kesehatan (penjasorkes) SD kelas bawah dalam proses pembelajaran penjasorkes. Penelitian ini merupakan penelitian deskriptif dengan menggunakan satu variabel, yaitu implementasi pendidikan keselamatan. Populasi yang digunakan dalam penelitian ini adalah guru penjasorkes SD Negeri se-Daerah Istimewa Yogyakarta (DIY) yang berjumlah 1.386 orang. Sampel yang digunakan sebanyak 200 orang yang diambil secara random (acak) dengan teknik cluster sampling atau area sampling. Data dikumpulkan dengan menggunakan metode survei dengan teknik angket. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik deskriptif kuantitatif dengan persentase. Hasil penelitian menunjukkan implementasi pendidikan keselamatan yang dilakukan oleh guru penjasorkes SD kelas bawah dalam proses pembelajaran penjasorkes adalah sebagai berikut. Pertama, yang termasuk dalam kategori cukup adalah secara keseluruhan (82,69%), berdasarkan aspek lingkungan (78,92%), aspek peserta didik (81,94%), aspek fisik (84,19%), dan aspek cuaca (73,65%). Kedua, yang termasuk kategori baik adalah berdasarkan aspek manusia (86,46%) dan aspek guru (90,99%).
Faktor yang Mempengaruhi Niat Mengadopsi Usahatani Sayuran Organik di Kecamatan Getasan Semarang
Authors: Yasyak Vaniamon Wira , Hardyastuti Suhatmini , Hartono Slamet 
Published: July 2020

Organic farming has attracted increasing attention in recent decades. Many believe this is necessary to maintain agricultural production while addressing environmental damages caused by conventional farming methods. However, the adoption of organic vegetable farming in Indonesia is still fairly slow. The fact that only a small number of farmers adopt organic farming begs explanation. Studies have shown that intention determines human behaviors. The problem is that intention to choose organic farming does not always manifest in behavior. To address this problem it is helpful to consider three factors affect how intention manifest in behavior, namely attitudes, subjective norms, and behavioral control. Based on in the case study on the central vegetable farming area of Kopeng village where conventional farming is still dominant, this paper analyzes the intention organic farmers in the light of the theory of planned behavior. Applying the SEM-PLS model of analysis, it identifies the key-driver organic farmers. This study found that farmers’ positive attitude toward organic farming is not the main drive in their shift from non-organic to organic farming. Rather than subjective norms, behavior control has the greater influence on the farmers’ choice to adopt organic vegetable farming. Famers view organic agriculture positively; but the main obstacle is the access to information about organics, certification capabilities and other aspects of behavioral control which make adoption rate for organic vegetable farming is still low.
DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF ANTIPSYCHOTIC DRUG ASENAPINE MALEATE IN PURE AND DOSAGE FORMS
Authors: EL-SHEIKH RAGAA , ELLATEIF AHLAM E. ABD , AKMAL ESRAA , GOUDA AYMAN A. 
Published: July 2020

Objective: Three sensitive, simple, precise, reproducible, and validated spectrophotometric methods have been developed for the determination of anti-psychotic drug (asenapine maleate) in pure and pharmaceutical dosage forms.
Methods: The methods are based on the formation of yellow-colored ion-pair complex between asenapine maleate and three acid dyes, namely, bromocresol purple (BCP), bromophenol blue (BPB) and bromothymol blue (BTB) with absorption maxima at 410, 414 and 416 nm, respectively. Several parameters such as pH, buffer type and volume, reagent volume, the sequence of addition and effect of extracting solvent were optimized.
Results: Under the optimum experimental conditions, beer’s law is obeyed over the concentration ranges of 1.0–20, 1.0–14, and 1.0-16 μg/ml for BCP, BPB and BTB, respectively, with good correlation coefficients (0.9994-0.9998). The apparent molar absorptivity and Sandell’s sensitivity values are reported for all methods. The limit of detection (LOD) and the limit of quantification (LOQ) values are found to be 0.27, 0.30, and 0.25 μg/ml and 0.90, 1.0, and 0.83 μg/ml for BCP, BPB and BTB, respectively. The stoichiometric ratio of the formed ion-pair complexes was found to be 1:1 (drug: reagent) for all methods, as deduced by Job's method of continuous variation.
Conclusion: The proposed methods were successfully applied for the determination of asenapine maleate in pharmaceutical formulations with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and variance ratio F-test at the 95% confidence level and there was no significant difference between the reported and proposed methods regarding accuracy and precision. Further, the validity of the proposed methods was confirmed by recovery studies via standard addition technique in accordance with ICH guidelines.