bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers
Authors:   GENEPSO, Mavaddat Nasim ,   EMBRACE,   HEBON,   kConFab Investigators,   on behalf of IBCCS,   kConFab,   BCFR, Antoniou Antonis C. , Mooij Thea M. , Hooning Maartje J. , Heemskerk-Gerritsen Bernadette A. , Noguès Catherine , Gauthier-Villars Marion , Caron Olivier , Gesta Paul , Pujol Pascal , Lortholary Alain , Barrowdale Daniel , Frost Debra , Evans D. Gareth , Izatt Louise , Adlard Julian , Eeles Ros , Brewer Carole , Tischkowitz Marc , Henderson Alex , Cook Jackie , Eccles Diana , van Engelen Klaartje , Mourits Marian J. E. , Ausems Margreet G. E. M. , Koppert Linetta B. , Hopper John L. , John Esther M. , Chung Wendy K. , Andrulis Irene L. , Daly Mary B. , Buys Saundra S. , Benitez Javier , Caldes Trinidad , Jakubowska Anna , Simard Jacques , Singer Christian F. , Tan Yen , Olah Edith , Navratilova Marie , Foretova Lenka , Gerdes Anne-Marie , Roos-Blom Marie-José , Van Leeuwen Flora E. , Arver Brita , Olsson Håkan , Schmutzler Rita K. , Engel Christoph , Kast Karin , Phillips Kelly-Anne , Terry Mary Beth , Milne Roger L. , Goldgar David E. , Rookus Matti A. , Andrieu Nadine , Easton Douglas F. 
Published: January 2020

AbstractBackgroundThe effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk forBRCA1andBRCA2mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly forBRCA2mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural menopause.MethodsA multi-centre prospective cohort of 2272BRCA1and 1605BRCA2mutation carriers was followed for a mean of 5.4 and 4.9 years, respectively; 426 women developed incident breast cancer. RRSO was modelled as a time-dependent covariate in Cox regression, and its effect assessed in premenopausal and postmenopausal women.ResultsThere was no association between RRSO and breast cancer forBRCA1(HR = 1.23; 95% CI 0.94–1.61) orBRCA2(HR = 0.88; 95% CI 0.62–1.24) mutation carriers. ForBRCA2mutation carriers, HRs were 0.68 (95% CI 0.40–1.15) and 1.07 (95% CI 0.69–1.64) for RRSO carried out before or after age 45 years, respectively. The HR forBRCA2mutation carriers decreased with increasing time since RRSO (HR = 0.51; 95% CI 0.26–0.99 for 5 years or longer after RRSO). Estimates for premenopausal women were similar.ConclusionWe found no evidence that RRSO reduces breast cancer risk forBRCA1mutation carriers. A potentially beneficial effect forBRCA2mutation carriers was observed, particularly after 5 years following RRSO. These results may inform counselling and management of carriers with respect to RRSO.
Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers
Authors: Egorova Olga , Myte Robin , Schneede Jörn , Hägglöf Bruno , Bölte Sven , Domellöf Erik , Ivars A’roch Barbro , Elgh Fredrik , Ueland Per Magne , Silfverdal Sven-Arne 
Published: January 2020

AbstractBackgroundAutism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis.MethodsSerum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B9) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation.ResultsWe found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22–2.37, FDR adjustedP= 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D3levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring.ConclusionsOur findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted.
An edge computing framework based on OFDM radar for low grazing angle target tracking
Authors: Karimi Vahid , Mohseni Reza , Khosravi Mohammad R. 
Published: January 2020

AbstractIn this paper, a novel adaptive algorithm to detect and track targets with low grazing angle is addressed. For this purpose, an orthogonal frequency division multiplexing (OFDM) radar signal is employed through an edge computing framework over the radar platform. However, detecting the targets in the low grazing angle area is a great challenge due to severe multipath reflection effects. The Earth’s curvature geometry model is presented as the multipath propagation model. Based on the fact that the different scattering centers of a target resonate at different frequencies, we use the optimized OFDM waveform and propose a novel target tracking procedure for low grazing angle target tracking scenarios. The obtained results show that using an OFDM radar waveform provides a more uniform detection coverage in the presence of multipath propagation such that this will fill in the nulls. Finally, simulations are used to compare the performance of the proposed OFDM waveform with the conventional equal-power, the generalized likelihood ratio (GLR)-based and single-carrier waveforms.
Engaging older adults in self-management talk in healthcare encounters: a systematic review protocol
Authors: Lawless Michael T. , Drioli-Phillips Phoebe , Archibald Mandy M. , Kitson Alison L. 
Published: January 2020

Abstract
Background
Clinical practice guidelines for the management of complex chronic conditions in older adults encourage healthcare providers to engage patients in shared decision-making about self-management goals and actions. Yet, healthcare decision-making and communication for this population can pose significant challenges. As a result, healthcare professionals may struggle to help patients define and prioritise their values, goals, and preferences in ways that are clinically and personally meaningful, incorporating physical functioning and quality of life, when faced with numerous diagnostic and treatment alternatives. The aim of this systematic review is to locate and synthesise a body of fine-grained observational research on communication between professionals, older adults, and carers regarding self-management in audio/audio-visually recorded naturalistic interactions.

Methods/design
The paper describes a systematic review of the published conversation analytic and discourse analytic research, using an aggregative thematic approach and following the PRISMA-P guidelines. This review will include studies reporting on adult patients (female or male) aged ≥ 60 years whose consultations are conducted in English in any healthcare setting and stakeholders involved in their care, e.g. general practitioners, nurses, allied health professionals, and family carers. We will search nine electronic databases and the grey literature and two independent reviewers will screen titles and abstracts to identify potential studies. Discrepancies will be resolved via consultation with the review team. The methodological quality of the final set of included studies will be appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research and a detailed description of the characteristics of the included studies using a customised template.

Discussion
This is the first systematic review to date to locate and synthesise the conversation analytic research on how healthcare professionals raise and pursue talk about self-management with older adults in routine clinical interactions. Amalgamating these findings will enable the identification of effective and potentially trainable communication practices for engaging older adults in healthcare decision-making about the self-management goals and actions that enable the greatest possible health and quality of life in older adulthood.

Systematic review registration
PROSPERO CRD42019139376
Developing a clinical decision support for opioid use disorders: a NIDA center for the clinical trials network working group report
Authors: Bart Gavin B. , Saxon Andrew , Fiellin David A. , McNeely Jennifer , Muench John P. , Shanahan Christopher W. , Huntley Kristen , Gore-Langton Robert E. 
Published: January 2020

AbstractThere is an urgent need for strategies to address the US epidemic of prescription opioid, heroin and fentanyl-related overdoses, misuse, addiction, and diversion. Evidence-based treatment such as medications for opioid use disorder (MOUD) are available but lack numbers of providers offering these services to meet the demands. Availability of electronic health record (EHR) systems has greatly increased and led to innovative quality improvement initiatives but this has not yet been optimized to address the opioid epidemic or to treat opioid use disorder (OUD). This report from a clinical decision support (CDS) working group convened by the NIDA Center for the Clinical Trials Network aims to converge electronic technology in the EHR with the urgent need to improve screening, identification, and treatment of OUD in primary care settings through the development of a CDS algorithm that could be implemented as a tool in the EHR. This aim is consistent with federal, state and local government and private sector efforts to improve access and quality of MOUD treatment for OUD, existing clinical quality and HEDIS measures for OUD or drug and alcohol use disorders, and with a recent draft grade B recommendation from the US Preventative Services Task Force (USPSTF) for screening for illicit drug use in adults when appropriate diagnosis, treatment and care services can be offered or referred. Through a face-to-face expert panel meeting and multiple follow-up conference calls, the working group drafted CDS algorithms for clinical care felt to be essential for screening, diagnosis, and management of OUD in primary care. The CDS algorithm was reviewed by addiction specialists and primary care providers and revised based on their input. A clinical decision support tool for OUD screening, assessment, and treatment within primary care systems may help improve healthcare delivery to help address the current epidemic of opioid misuse and overdose that has outpaced the capacity of specialized treatment settings. A semi-structured outline of clinical decision support for OUD was developed to facilitate implementation within the EHR. Further work for adaptation at specific sites and for testing is needed.
Dual-label time-resolved fluoroimmunoassay for simultaneous measurement of human epidermal growth factor receptor 2 and human epididymis protein 4 in serum
Authors: Zhang Yi , Wang Ke , Zhao Ying , Fan Jun , Han Tingting , Si Yu-an , Zhou Bin , Zhang Jue , Hu Zhigang , Xie Minhao 
Published: January 2020

AbstractIn this study, a novel dual-label time-resolved fluoroimmunoassay (TRFIA) is described for simultaneous quantification of human epidermal growth factor receptor 2 (HER-2) and human epididymis protein 4 (HE4) in serum to screen gynecologic cancers. A double-antibody sandwich TRFIA was introduced with europium and samarium chelates to simultaneously detect the concentrations of HER-2 and HE4. Under optimal conditions, the proposed method exhibited wide linear ranges for HER-2 of 0.07–500 ng ml−1 and for HE4 of 0.32–1000 pmol l−1 with the average coefficient of variation below 10%. The specificity was satisfied through determining the other common tumor markers. The recovery rates were 94.5% and 96.6% on average for HER-2 and HE4, respectively. Good correlations were observed in clinical samples between developed method and commercial chemiluminescence immunoassay kits. The results demonstrated that dual-label TRFIA for HER-2 and HE4 was rapid and precise, and therefore could have a promising use in large sample detection for gynecological cancer screening.
Evidence for terrane boundaries and suture zones across Southern Mongolia detected with a 2-dimensional magnetotelluric transect
Authors: Comeau Matthew J. , Becken Michael , Käufl Johannes S. , Grayver Alexander V. , Kuvshinov Alexey V. , Tserendug Shoovdor , Batmagnai Erdenechimeg , Demberel Sodnomsambuu 
Published: January 2020

AbstractSouthern Mongolia is part of the Central Asian Orogenic Belt, the origin and evolution of which is not fully known and is often debated. It is composed of several east–west trending lithostratigraphic domains that are attributed to an assemblage of accreted terranes or tectonic zones. This is in contrast to Central Mongolia, which is dominated by a cratonic block in the Hangai region. Terranes are typically bounded by suture zones that are expected to be deep-reaching, but may be difficult to identify based on observable surface fault traces alone. Thus, attempts to match lithostratigraphic domains to surface faulting have revealed some disagreements in the positions of suspected terranes. Furthermore, the subsurface structure of this region remains relatively unknown. Therefore, high-resolution geophysical data are required to determine the locations of terrane boundaries. Magnetotelluric data and telluric-only data were acquired across Southern Mongolia on a profile along a longitude of approximately 100.5° E. The profile extends ~ 350 km from the Hangai Mountains, across the Gobi–Altai Mountains, to the China–Mongolia border. The data were used to generate an electrical resistivity model of the crust and upper mantle, presented here, that can contribute to the understanding of the structure of this region, and of the evolution of the Central Asian Orogenic Belt. The resistivity model shows a generally resistive upper crust (0–20 km) with several anomalously conductive features that are believed to indicate suture zones and the boundaries of tectonic zones. Moreover, their spatial distribution is coincident with known surface fault segments and active seismicity. The lower crust (30–45 km) becomes generally less resistive, but contains an anomalously conductive feature below the Gobi–Altai zone. This potentially agrees with studies that have argued for an allochthonous lower crust below this region that has been relaminated and metamorphosed. Furthermore, there is a large contrast in the electrical properties between identified tectonic zones, due to their unique tectonic histories. Although penetration to greater depths is limited, the magnetotelluric data indicate a thick lithosphere below Southern Mongolia, in contrast to the previously reported thin lithosphere below Central Mongolia.
Stafne’s bone cyst revisited and renamed: the benign mandibular concavity
Authors: Aps Johan K.M. , Koelmeyer Natasha , Yaqub Cina 
Published: January 2020

Objective:Stafne’s bone cyst (SBC) is an asymptomatic, round or oval-shaped, well-defined, uniform radiolucent lesion, usually incidentally observed in the posterior aspects of the mandible. Radiographical appearance may be confusing though. This study aimed to review the literature on SBCs and to map the SBC as shown in their respective papers.Methods:A Pubmed® search (1/9/2018 till 31/5/2019), mentioning SBC, was carried out. Included papers had to contain: patient’s age, gender and radiographs.Results:In total, 114 papers were found, but only 64 papers were retained, which contained 109 cases (95 males, 14 females). The patients’ ages ranged between 14 and 89 years old (mean age being 52 years). Male patients’ ages (N = 95) ranged from 14 to 89 years (mean age 52.3 years), whereas the females (N = 14) ages ranged between 22 and 68 (mean age 50.2 years). 28 combinations of locations of SBC were recorded. Only three lesions were located at the symphysis, six were bilateral, 55 appeared on the left hand side and 45 on the right hand side of the mandible.The literature mentioned that these cavities could contain salivary gland tissue, muscular tissue, lymphoid tissue, blood vessels, fat tissue or connective tissue.Discussion/Conclusion:This study illustrates the wide variation of SBC locations across the mandible and leads us to conclude that the differential diagnosis of every asymptomatic, oval or round, well-defined, uniform radiolucent lesion on two-dimensional radiographs of the mandible should include “a benign mandibular concavity”, formerly known as SBC.
Patterns of functional diversity of macroinvertebrates across three aquatic ecosystem types, NE Mediterranean
Authors: GJONI VOJSAVA , GHINIS STAMATIS , PINNA MAURIZIO , MAZZOTTA LUCA , MARINI GABRIELE , CIOTTI MARIO , ROSATI ILARIA , VIGNES FABIO , ARIMA SERENA , BASSET ALBERTO 
Published: January 2020

This study is focused on investigating the variation patterns of macroinvertebrate guilds functional structure, in relation to the taxonomic one, across aquatic ecosystem types along the salinity gradient from freshwater to marine and the resulting implications on guild organization and energy flows. Synoptic samplings have been carried out using the leaf-pack technique at 30 sites of the aquatic ecosystems of the Corfu Island (Greece), including freshwater, lagoon, and marine sites. Here, we analyzed the macroinvertebrate guilds of river, lagoon, and marine ecosystems, as: i. taxonomic composition and population abundance ii. trophic guilds composition and relative abundance; and iii. body size spectra and size patterns. The following variation patterns across the three ecosystem types were observed: a. trophic guild composition and body size spectra were more conservative than taxonomic composition within and among ecosystem types, where, trophic guild and size spectra composition were more similar between river and lagoon ecosystem types than with marine ones; b. a dominance on resource exploitation of large species over smaller ones was inferred at all sites; and, c. higher body size-specific density of individuals was consistently observed in lagoon than in freshwater and marine ecosystems. Results extend previous findings suggesting a common hierarchical organization of benthic macroinvertebrate guilds in aquatic ecosystems and showing that lagoon ecosystems have higher energy density transferred to benthic macroinvertebrates than both freshwater and marine ecosystem types.
Research on photonic crystal fiber based on a surface plasmon resonance sensor with segmented silver-titanium dioxide film
Authors: Fang Hairui , Wei Chenjing , Wang Dong , Yuan Long , Jiao Shengxi , Bao Zhiyu , Yang Hanrui 
Published: January 2020

A photonic crystal fiber based on a surface plasmon resonance sensor coated with segmented silver-titanium dioxide (

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varying from 1.330 to 1.360, which can be applied to the field of chemical and biological analysis.
Dear Simona
Authors: Matthis Milan Marković 
Published: January 2020

Abstract
»Dear Simona« is a short article in which the author employs the lyrical format of a letter to the renowned playwright Simona Semenič: on the one hand, in order to describe some potential directions of analyzing her writing, on the other to ponder on their private relationship. The first part of the text deals with the relationship between theatre and society, the second with relationships between genders, and the third with the relationship between intimate and public.
Užitek dela in delo užitka: Intervju z Giulio Palladini
Authors: Kaluža Jernej 
Published: January 2020

Povzetek
V intervjuju se Jernej Kaluža pogovarja z raziskovalko in kritično teoretičarko Giullio Palladini, avtorico knjige Prizorišče predigre (The Scene of Foreplay, 2017). Beseda teče o razliki med teorijo in prakso; o užitku v (umetniškem) delu; samoeksploataciji, ekspemplaričnosti specifičnega načina dela v umetnosti; o načinu dela, ki lahko uide logiki vrhunca; o kvaliteti in vrednosti; konkurenčniški logiki in njenemu preseganju ter drugih temah.
The pleasure of work and the work of pleasure: Interview with Giulia Palladini
Authors: Kaluža Jernej 
Published: January 2020

Abstract
Jernej Kaluža interviewed the researcher and critical theoretician Giullia Palladini, author of The Scene of Foreplay, 2017. They talk about the difference between theory and practice; the pleasure of (art)work; self-exploitation, the exemplarity of a specific type of work in the arts; a type of work capable of escaping the logic of climax; quality and value; competition logics and its surpassing; and other topics.
Impulstanz 2019: Nekaj misli
Authors: Brezavšček Pia , Lobnik Alja 
Published: January 2020

Povzetek
Urednici pričujoče revije sta v okviru rezidenčnega bivanja na Dunaju obiskali del festivala ImpulsTanz, da bi zmapirali mednarodne trende na področju sodobnega plesa. Ugotovili sta, da je na sodobnoplesni sceni ob povečani produkciji upadel interes za teorijo, kamor se že vrsto let pomembno umešča tudi delo revije Maska. Produkcijo sta razvrstili v tri kategorije: ples velikih imen (tu omenita Iva Dimcheva z delom Selfie Concert, Jonathana Burrowsa z delom Rewriting, komad Wima Vandekeybusa/Ultima Vez Go Figure Out Yourself ter klasiko DD Dorvillier/Human Future Dance Corps: No Change, or »freedom is a psycho-kinetic Skill«), mesto gledalca in hermetizmi aktualnega sodobnega plesa (tu obravnavata delo Anne Juren 42, solo Dani Michel Cutlass Spring in Compass Simone Augherlony, Petre Hrašćanec in Saše Božića) ter novi formalizmi in sodobna repeticija (Tatiana Chizhikova in Roman Kutnov: Time to time in Ellen Furey in Malik Nashad Sharpe: SOFTLAMP.Autonomies,).
Preglej overview
Authors: Simoneti Jaka Smerkolj 
Published: January 2020

Abstract
The text attempts to give a clear outline of the landscape of contemporary Slovenian drama, the two main turning points being the Preglej group and Simona Semenič as a key figure in both Preglej and the future development of Slovenian playwriting. It focuses on production, attempting to give a rundown of playwrights' existing production practices and call attention to some of their major breakthroughs, as well as on reception by pointing out the lack of drama criticism and the lack of publication and distribution of new plays.