bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Body Mass Index, Uric Acid Levels, and Lower Cholesterol Levels are Associated with Greater Weight Loss
Authors: De Pergola Giovanni , Zupo Roberta , Lampignano Luisa , Bonfiglio Caterina , Giannelli Gianluigi , Osella Alberto R. , Triggiani Vincenzo 
Published: April 2020

Background:
Identifying predictive factors that contribute to changes in body weight may
well be an interesting approach to the management of obesity.

Objective:
This study was firstly aimed at examining the effect of a one-year lifestyle program based
on improvements in the habitual diet and increased levels of physical activity on weight loss. Secondly,
it was focused on identifying anthropometric, and serum hormonal, metabolic and haematochemical
factors which can be associated with the degree of weight loss in Kg.

Methods:
488 overweight or obese subjects, 383 women and 105 men, aged 18-67 years, were enrolled
in the study. Body mass index, waist circumference, serum blood glucose, lipids, uric acid, creatinine,
insulin, TSH, FT3, FT4, and 24-h urine catecholamines were measured.

Results:
Weight loss was positively associated with BMI (P < 0.01), waist circumference (P < 0.01),
uric acid (P < 0.01), creatinine (P < 0.05), smoking (P < 0.01), and negatively correlated with age (P <
0.01), total cholesterol (P < 0.05), LDL-cholesterol (P < 0.01), HDL cholesterol (P < 0.05). In a multiple
regression model considering weight loss as a dependent variable, and smoking, age, BMI, uric
acid, creatinine, total cholesterol, LDL-cholesterol and HDL cholesterol as independent variables,
weight loss maintained a direct independent relationship with BMI (P < 0.001), uric acid (P < 0.05),
LDL-cholesterol (P < 0.05), and HDL-cholesterol (P < 0.05), and an inverse independent association
with cholesterol (P < 0.01).

Conclusions:
This study suggests that higher BMI and uric acid levels, and lower total cholesterol concentrations
are associated with a greater potential to lose weight.
Polymer Coated Iron Nanoparticles: Radiolabeling & In vitro Studies
Authors: Yilmaz Selin , Ichedef Cigdem , Karatay Kadriye Buşra , Teksöz Serap 
Published: April 2020

Backgorund:
Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively
used for targeted drug delivery systems due to their unique magnetic properties. Objective:
In this study, it has been aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery
system for Gemcitabine (GEM).

Methods:
Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA)
together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc.
SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid
for surface modification. Size distribution and the morphology of the synthesized nanoparticles
were characterized by dynamic light scattering (DLS) and scanning electron microscopy (SEM), respectively.
The radiolabeling yield of SPION-PLGAGEM nanoparticles was determined via Thin
Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA was investigated
on MDA-MB-231 and MCF7 breast cancer cells in vitro.

Results:
SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and
the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles was determined
as 366.6 nm by DLS, while zeta potential was found as 29 mV. SPION was successfully
coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA
was calculated as 4±0.16% by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM
nanoparticles was determined as 97.8±1.75% via TLRC. Cytotoxicity of GEM loaded SPION-PLGA
was investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM
showed high uptake on MCF-7, while the incorporation rate was increased for both cell lines with
external magnetic field application.

Conclusion:
99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of
the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and superparamagnetic
characteristics.
Persulfate-mediated Photocatalytic Degradation of Ciprofloxacin in Water Using Ultraviolet Light and Zero-valent Aluminum
Authors: Olmez-Hanci Tugba , Arslan-Alaton Idil 
Published: April 2020

Aims:
The study aimed at assessing the effectiveness of the PS/UV-C, PS/ZVA and
PS/ZVA/UV-C processes in terms of ciprofloxacin, a fluoroquinolone type commercially important
antibiotic, and toxicity abatements in raw surface water (RSW) and distilled water (DW).

Background:
The occurrence of ciprofloxacin (CIP), the most widely prescribed second-generation
fluoroquinolone antibiotic, even at trace level (ng/L) gives rise to antibiotic resistant bacteria and resistance
genes, which can further impair the selection of genetic variants of microorganisms and impose
adverse effect on human health.

Objective:
The degradation and detoxification of ciprofloxacin with UV-C (PS/UV-C) and ZVA
(PS/ZVA) activated PS oxidation systems were investigated in distilled water (DW) and raw (untreated)
surface water (RSW) samples. Moreover, CIP degradation with the PS/ZVA/UV-C heterogeneous
photochemical treatment combination was also studied.

Methods:
The process performances of the investigated treatment systems were evaluated in terms of
CIP abatement and PS consumption rates as well as dissolved organic carbon (DOC) removal efficiencies.
The influence of common inorganic ions and natural organic matter (NOM) on CIP degradation
was evaluated. Radical quenching experiments were conducted using probe compounds in order
to elucidate the dominant reaction mechanism. In addition, acute toxicity of the original CIP and its
degradation products were questioned by employing Vibrio fischeri (V. fischeri), the marine photobacterium,
under optimized treatment conditions.

Results:
CIP was completely degraded in distilled water (DW) and raw (untreated) surface water
(RSW) samples after 15 min of treatment with the PS/UV-C process (PS=0.25mM; pH=3; UVC=
2.7W/m2). PS/UV-C experiments conducted with RSW at its natural pH (=8.5) resulted in 98%
CIP and practically no DOC removal whereas 56% DOC was removed at pH 3 after 120 min. Radical
quenching studies revealed that sulfate radicals prevailed over hydroxyl radicals. CIP degradation was
significantly inhibited by the presence of humic acid due to the effect of UV absorption and free radical
quenching. Acute toxicity tests with V. fischeri exhibited fluctuating trends throughout the investigated
processes and did not change appreciably after 120 min of oxidation.

Conclusion:
The results of this study demonstrated that PS/UV-C is superior to the PS/ZVA and
PS/ZVA/UV-C treatment systems for both DW and RSW samples in terms of CIP removal rates. No
additional positive effect was evident for simultaneous catalytic and photochemical PS activation
(PS/ZVA/UV-C treatment system). It could be also demonstrated that the selected oxidation processes
conducted in pure water might give an idea about the advanced treatment systems but realistic conditions
with actual water/wastewater matrices still need to be further investigated to verify their feasibility
and ecotoxicological safety.
Trajektori Pertumbuhan Anak Stunting dan Normal di Indonesia
Authors: Asanti Ernis , Martianto Drajat , Briawan Dodik 
Published: April 2020

Abstrak Secara global, kegagalan pertumbuhan linier merupakan bentuk paling umum dari kekurangan giziÂ pada masa anak-anak, dimana sekitar 165 juta anak balita mengalami stunting. Akan tetapi, masih terdapat perdebatan mengenai kaitan antara stunting pada anak-anak dengan kejadian kegemukan maupun obesitas pada usia-usia selanjutnya. Penelitian ini bertujuan untuk menganalisis trajektori IMT/U dari anak-anak hingga remaja pada anak yang memiliki riwayat stunting dan normal. Penelitian ini merupakan penelitian kohort retrospektif, dengan menggunakan data sekunder Indonesia Family Life Survey (IFLS) yang merupakan kolaborasi dari Research and Development (RAND) dan Survey Meter. Subjek pada penelitian ini adalah 314 (43.6%) anak yang memenuhi kriteria inklusi dan eksklusi. Pendekatan yang digunakan untuk mempelajari trajektori IMT/U adalah Individual Growth Curve (IGC) model. Analisis IGC dilakukan dengan prosedur Linear Mixed Model pada IBM SPSS Statistics versi 25. Hasil penelitian ini menunjukkan bahwa terdapat selisih nilai z-score IMT/U sebesar 0.505 (Î²= -0.505; SE= 0.138; p<0.01) antara anak yang mengalami stunting dan normal pada awal pengukuran. Nilai z-score IMT/U anak stunted akan mengalami penurunan 0.078 kali lebih kecil (Î²= -0.078; SE= 0.011; p<0.01), akan tetapi kemudian mengalami peningkatan 0.011 kali lebih tinggi (Î²= 0.01; SE= 0.002; p<0.01) dibandingkan dengan anak normal. Penelitian ini menunjukkan bahwa terdapat perbedaan trajektori IMT/U anak yang memiliki riwayat stunting dan normal.Kata kunci: IMT/U; stunting; trajektoriÂ Abstract Â Globally, linear growth failure is the most common form of childhood malnutrition, with around 165 million children under five are stunting. However, the link between stunting in children with the risk of overweight or obesity at later ages are still debated. This study aimed to analyze the trajectory of BAZ from children to adolescents in children who were stunted and normal. This study was a retrospective cohort study, using secondary data from the Indonesia Family Life Survey (IFLS) which is a collaboration of RAND and Survey Meter. The subjects in this study were 314 (43.6%) children who met the inclusion and exclusion criteria. BAZ trajectory approach used was the Individual Growth Curve (IGC) model. IGC analysis was carried out by Linear Mixed Model procedure using IBM SPSS Statistics version 25.Â This study indicated that there was a 0.505 (Î²= -0.505; SE= 0.138; p<0.01) difference in the z-score of BAZ between children who were stunted and normal at the initial measurement. The decreasing of stunted childâ€™s BAZ was 0.078 times smaller (Î²= -0.078; SE= 0.011; p<0.01), but then the BAZ would increase 0.011 times higher (Î²= 0.01; SE= 0.002; p<0.01) than the normal children. This study showed that there were differences of BAZ trajectory between stunted and normal children. Keywords: BAZ; stunting; trajectory
Feasibility of Social Media–Based Recruitment and Perceived Acceptability of Digital Health Interventions for Caregivers of Justice-Involved Youth: Mixed Methods Study
Authors: Folk Johanna Bailey , Harrison Anna , Rodriguez Christopher , Wallace Amanda , Tolou-Shams Marina 
Published: April 2020

Background
Caregiver involvement is critical for supporting positive behavioral health and legal outcomes for justice-involved youth; however, recruiting this population into clinical research studies and engaging them in treatment remain challenging. Technology-based approaches are a promising, yet understudied avenue for recruiting and intervening with caregivers of justice-involved youth.

Objective
This mixed methods study aimed to assess the feasibility of recruiting caregivers of justice-involved youth using social media into clinical research and to understand caregivers’ perceptions of the acceptability of digital health interventions.

Methods
Caregivers of justice-involved youth were recruited through paid Facebook advertisements to participate in a Web-based survey. Advertisement design was determined using Facebook A/B split testing, and the advertisement with the lowest cost per link click was used for the primary advertisement campaign. Survey participants were offered the option to participate in a follow-up qualitative phone interview focused on the perceived feasibility and acceptability of digital health interventions.

Results
Facebook advertisements were successful in quickly recruiting a diverse set of caregivers (80/153, 52.3% female; mean age 43 years, SD 7; 76/168, 45.2% black, 34/168, 20.2% white, and 28/168, 16.7% Latinx; and 97/156, 62.2% biological parents); cost per click was US $0.53, and conversion rate was 11.5%. Survey participants used multiple social media platforms; 60.1% (101/168) of the participants indicated they would participate in a digital health intervention for caregivers of justice-involved youth. Survey respondents’ most preferred intervention was supportive and motivational parenting messages via SMS text message. Of the survey respondents, 18 completed a phone interview (12/18, 67% female; mean age 45 years, SD 10; 10/18, 56% black, 7/18, 39% white, and 1/18, 6% Latinx; and 16/18, 89% biological parents). Interview participant responses suggested digital health interventions are acceptable, but they expressed both likes (eg, alleviates barriers to treatment access) and concerns (eg, privacy); their most preferred intervention was video-based family therapy.

Conclusions
Recruiting and intervening with caregivers of justice-involved youth through social media and other digital health approaches may be a feasible and acceptable approach to overcoming barriers to accessing traditional in-person behavioral health care.
Identifikasi Jelajah Wisata Geologi Gunung Api Purba Gunung Ireng: Sisi Lain Gunung Api Purba Nglanggeran, Gunungkidul
Authors: Mulyaningsih Sri 
Published: April 2020

Gunung Ireng di Desa Pengkok adalah destinasi wisata baru geologi gunung api purba di Kecamatan Patuk, Kabupaten Gunungkidul, di samping Gunung Nglanggeran. Selain aglomerat, sebagaimana penciri geologi Gunung Api Purba Nglanggeran, breksi vulkanik, lava bersruktur meniang, dike, dan blocky lava berkomposisi andesit menyusun Gunung Ireng. Makalah ini disusun untuk mengidentifikasi kealamian jelajah alam geologi gunung api purba Gunung Ireng sebagai destinasi wisata minat khusus geowisata. Metode yang digunakan adalah studi dan analisis konektivitas Gunung Ireng terhadap destinasi-destinasi wisata lain di sekitarnya dan identifikasi keragaman data geologinya. Penelitian menjumpai morfologi bukit melingkar berbentuk kubah, yang dikelilingi lembah berslope ~30-55o yang melandai ke baratlaut. Dari atas bukit terlihat Gunung Wayang (Nglanggeran di ujung timur), karst Selopamioro di arah selatan, Sudimoro di arah barat dan tinggian Patuk di sebelah utara. Jalur konektivitas telah menghubungkan Gunung Ireng dengan Gunung api Nglanggeran-Oro-Oro, Dlingo, Selopamioro dan Kali Ngalang-Gedangsari. Promosi dan dukungan sepenuhnya dari pemerintah Kabupaten Gunungkidul, serta optimisme pengelola adalah kunci keberhasilan Gunung Ireng untuk disejajarkan dengan destinasi-destinasi wisata minat khusus lain di sekitarnya; mendukung keberlanjutan Geopark Gunung Sewu.
Efficacy of Combination Dutasteride and Lycopene to Reduce Bleeding in Benign Prostate Hyperplasia (BPH) Post- Transurethral Resection of the Prostate (TURP) Overview of Hypoxia inducible factor-1 alpha (HIF-1 α) Expression and Hematocrit Levels
Authors: Agung Nugroho Eriawan , Amarwati Siti , Akhbar Nugroho 
Published: April 2020

Trans Urethral Resection of the Prostate (TURP) is one of the gold operating standards for people with Benign Prostate Hyperplasia (BPH), but the complications, like bleedings, often occur both in durante and post-surgery. The risk of bleeding in TURP is caused by angiogenesis. Hypoxia-Induced Factor-1 Alpha (HIF-1 α) is one of the trigger factors for angiogenesis in BPH. Based on the existing literature, it was found that there was a relationship between lycopene and dutasteride which both had a synergistic effect in inhibiting angiogenesis. However, the mechanism is unknown. This study aims to assess the effectiveness of the combination of dutasteride and lycopene on the expression of HIF-1α and hematocrit levels in BPH patients undergoing TURP surgery. This research was an experimental study with "Double-Blind Randomized Controlled Trial Post Test Only Design". The 22 patients were divided into 2 groups, namely T (dutasteride + lycopene), C (lycopene+plasebo), which were given every 24 hours for a minimum of 30 days until the TURP operation was carried out. The observation of HIF-1α expression used immunohistochemical methods. Different tests were conducted between the groups with Independent T-test. The result shows the combination of dutasteride and lycopene was not significant in reducing the HIF-1α expression, indicated by mean rank in the group (C) (= 21.60), group (T) (= 20.00). The results obtained from the Independent T-test were (p = 0.410), meaning the difference in HIF-1α expression between the 2 groups was not significant: Average Δ Ht group C (= 1.26); group T (= -0,98). The statistical test with the Independent T-test obtained (p = 0.027), where there were significant differences. Giving a combination of dutasteride and lycopene for at least 30 days pre-TURP surgery was not effective in reducing the expression of hypoxia-induced factor - 1 alpha (HIF-1α) but was effective in reducing hematocrit levels compared to a single administration of dutasteride in BPH patients undergoing TURP surgery.
JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA Nephropathy
Authors: Tao Jianling , Mariani Laura , Eddy Sean , Maecker Holden , Kambham Neeraja , Mehta Kshama , Hartman John , Wang Weiqi , Kretzler Matthias , Lafayette Richard A. 
Published: April 2020

Background and objectives
IgA nephropathy is the most common primary glomerular disease in the world. Marked by mesangial inflammation and proliferation, it generally leads to progressive kidney fibrosis. As the Janus kinase signal transducer and activator of transcription pathway has been implicated as an important mediator of diabetic kidney disease and FSGS, detailed investigation of this pathway in IgA nephropathy was undertaken to establish the basis for targeting this pathway across glomerular diseases.

Design, setting, participants, & measurements
Well characterized patients with IgA nephropathy and controls were studied, allowing us to compare 77 patients with biopsy-proven IgA nephropathy with 45 healthy subjects. STAT phosphorylation was assessed in peripheral blood monocytes (PBMCs) by phosphoflow before and after cytokine stimulation. Kidney Janus kinase signal transducer and activator of transcription activity was studied by immunofluorescence and by transcriptomic studies. An STAT1 activity score was established using downstream transcriptional targets of pSTAT1 and associated with disease and clinical outcomes.

Results
We found PBMCs to have upregulated pSTAT production at baseline in patients with IgA nephropathy with a limited reserve to respond to cytokine stimulation compared with controls. Increased staining in glomerular mesangium and endothelium was seen for Jak-2 and pSTAT1 and in the tubulointerstitial for JAK2, pSTAT1, and pSTAT3. Activation of the Janus kinase signal transducer and activator of transcription pathway was further supported by increased pSTAT1 and pSTAT3 scores in glomerular and tubulointerstitial sections of the kidney (glomerular activation Z scores: 7.1 and 4.5, respectively; P values: <0.001 and <0.001, respectively). Clinically, phosphoflow results associated with proteinuria and kidney function, and STAT1 activation associated with proteinuria but was not associated with progression.

Conclusions
Janus kinase signal transducer and activator of transcription signaling was activated in patients with IgA nephropathy compared with controls. There were altered responses in peripheral immune cells and increased message and activated proteins in the kidney. These changes variably related to proteinuria and kidney function.
Opiniones de expertos para propuesta a modificación del Oral Health Impact Profile 49 en español
Authors: Ramírez Fernando , Navarrete Diego , Quezada Camila , Vera Paula 
Published: April 2020

Objetivo: El Oral Health Impact Profile 49 en español (OHIP-49 sp), es un instrumento que se utiliza para evaluar la calidad de vida relacionada a salud oral. Este es un cuestionario que consta de 49 preguntas cualitativas.Tras el estudio del instrumento OHIP-49 Sp se observó que carecía de una validación teórica, por lo que el objetivo principal fue identificar si es posible modificar el O-HIP 49 Sp mediante la opinión de un comité de expertos, con el fin de aplicarse en adultos mayores. Métodos: Para esto, se realizó un estudio descriptivo de corte transversal con un comité de experto compuesto por 8 profesionales con estudios en áreas geriátricas, odontogeriátricas, gerontológicas y/o experiencia en trabajo con adultos mayores. Resultados: Se evaluó cada pregunta correspondiente al cuestionario OHIP-49 Sp, en donde se obtuvo que en 13 preguntas se contestaron “en duda”, “desacuerdo” o “muy en desacuerdo” con la forma en que estas estaban formuladas. Finalmente 5 preguntas fueron seleccionadas como las peores formuladas y que por tanto se deberían modificar. Además, las preguntas se clasificaron según el tipo de crítica que recibieron, en donde varias de ellas obtuvieron más de un tipo de crítica, siendo la más frecuente la falta de claridad y ambigüedad. Conclusión: Tras analizar el cuestionario OHIP-49 Sp, se observó que efectivamente hay oportunidades de modificación respecto a la encuesta original.
Cárie oclusal: análise da variação do diagnóstico clínico e de sua fidelidade radiográfica e macroscópica
Authors: Silva Berenice Barbachan e , Domingues Manoela Gallicchio 
Published: April 2020

O objetivo deste estudo é examinar a concordância em relação ao diagnóstico clínico de cárie oclusal em 51 dentes extraídos, entre um grupo de examinadores formados por alunos do último ano da Faculdade de Odontologia-UFRGS, com posterior relacionamento dos achados com o exame radiográfico Bite-Wing e Macroscópico.
Os resultados da etapa clínica demonstram uma grande variação entre o grupo de examinadores, com concordância de 11,76%, além de baixa sensibilidade (0,15 e 0,12) e moderada especificidade (0,48 e 0,50) para exame clínico e radiográfico, respectivamente. Os estudos dos diferentes métodos de diagnóstico da superfície oclusal merecem maior atenção em busca de uma mair fidelidade.
PENINGKATAN PERTUMBUHAN TANAMAN JAGUNG ( Zea mays L.) MENGGUNAKAN JAMUR MIKORIZA ARBUSKULAR DARI JENIS YANG BERBEDA PADA KONDISI CEKAMAN AIR
Authors: Harso Wahyu , Isna Isna , Yusran Yusran 
Published: April 2020

Arbsucular mycorrhizal fungi promote plant growth by enhancing mineral uptake. Contribution degree of arbuscular mycorrhizal fungi to promote plant growth depend on species of plant-fungus association. The aim of this study was to compare the ability of three species of Glomus to promote maize plant growth. Maize plants were inoculated with 20 g inoculum of either Glomus deserticola, Glomus etunicatum, or Glomus clorum. Inoculum was soil containing spore, hyphae and infected root. Maize plants without addition inoculum were also used as a control. Water availability in the soil as growing medium was maintained on 40% field capacity. The results showed that addition of inoculum from three species of Glomus increased average of maize plant shoot dry weight although there was no statisticaly significant differences. Maize plant inoculated with G. clorum had higher shoot dry weight than maize plant inoculated either with G. etunicatum or G. deserticola while root colonization by G. clorum was lowest.