bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evaluation of the reporting quality of observational studies in Master of Public Health’s dissertations in China
Authors: Dai ShuangYang , Zhou Xiaobin , Xu Hong , Li Beibei , Zhang JinGao 
Published: June 2020

Abstract
Backgrounds Master of public health (MPH) plays an important role in Chinese medical education, and the dissertations is an important part of MPH education. In MPH dissertations, most are observational studies. Compared with randomized controlled trial (RCT), observational studies are more prone to information bias. So, the reporting of the observational studies should be transparent and standard. But, no research on evaluating the reporting quality of the MPH dissertation has been found.Methods A systematic literature search was performed in the Wanfang database from January 1, 2014 to May 31, 2019. The Strengthening the Reporting of Observation Studies in Epidemiology (STROBE) statement was adopted to evaluate the reporting quality of the selected studies. Articles that met the following criteria were selected: (1) observational studies, including cross-sectional studies, case-control studies, and cohort studies; (2) original articles; (3) studies on humans, including both adults and children.Results The Median of compliance to individual STROBE items was 74.79%. The mean (standard deviation) of STROBE score was 14.29 (1.84). Five items/sub-items were 100% reported (“reported” and “partly reported” were combined): background, objectives, study design, report numbers of individuals at each stage, and key result. Fifteen items/sub-items were reported by 75% or more. Reporting of methods and results was often omitted: missing data (6.67%), sensitivity analyses (3.63%), flow diagram (15.15%), and absolute risk (0%). Logistic regression analysis indicated that cohort studies (OR=3.41, 95% CI=1.27-9.16), funding support (OR=4.37, 95% CI=1.27-9.16) and more published papers during postgraduate period (OR=3.46, 95% CI=1.40-8.60) were related to high reporting quality.Conclusion In short, the reporting quality of observational studies in MPH’s dissertations in China is suboptimal. However, it’s necessary to improve the reporting of method and results sections. We recommend that authors should be stricter to adhere STROBE statement when conducting observational studies.
Genome-wide identification and characterization of cucumber bHLH family genes and the functional characterization of CsbHLH041 in NaCl and ABA tolerance in Arabidopsis and cucumber
Authors: Li Jialin , Wang Ting , Han Jing , Ren Zhonghai 
Published: June 2020

Abstract
Background: The basic/helix-loop-helix (bHLH) transcription factor family exists in all three eukaryotic kingdoms as important participants in biological growth and development. To date, the comprehensive genomic and functional analyses of bHLH genes has not been reported in cucumber (Cucumis sativus L.). Results: Here, a total of 142 bHLH genes were identified and classified into 32 subfamilies according to the conserved motifs, phylogenetic analysis and gene structures in cucumber. The sequences of CsbHLH proteins were highly conserved based on the results of multiple sequence alignment analyses. The chromosomal distribution, synteny analysis, and gene duplications of these 142 CsbHLHs were further analysed. Many elements related to stress responsiveness and plant hormones were present in the promoter regions of CsbHLH genes based on a cis-element analysis. By comparing the phylogeny of cucumber and Arabidopsis bHLH proteins, we found that cucumber bHLH proteins were clustered into different functional clades of Arabidopsis bHLH proteins. The expression analysis of selected CsbHLHs under abiotic stresses (NaCl, ABA and low-temperature treatments) identified five CsbHLH genes that could simultaneously respond to the three abiotic stresses. Tissue-specific expression profiles of these five genes were also analysed. In addition, 35S:CsbHLH041 enhanced the tolerance to salt and ABA in transgenic Arabidopsis and in cucumber seedlings, suggesting CsbHLH041 is an important regulator in response to abiotic stresses. Lastly, the functional interoperability network among the CsbHLH proteins was analysed. Conclusion: This study provided a good foundation for further research into the functions and regulatory mechanisms of CsbHLH proteins and identified candidate genes for stress resistance in cucumber.
MMP-13 Enzyme and pH Responsive Theranostic Nanoplatform for Osteoarthritis
Authors: lan qiumei , Chen Haimen , Pang Yunfen , Xiong Feng , Shen Chong , Qin Zainen , Zheng Li , Zhao Jinmin 
Published: June 2020

Abstract
Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables the development of stimulus-responsive drug delivery system with high specificity for OA. We herein demonstrate a nano-micelle based stimuli-responsive theranostic strategy with reporting and drug release controlled by acidic PH and MMP-13 for OA therapy. Such nanoplatform is incorporated with a motif specifically targeting on cartilage, a motif responsive to matrix metalloproteinases-13 to specifically report OA condition and biodynamics of nano-micelles, an anti-inflammatory drug (e.g., psoralidin (PSO)) from traditional Chinese medicine, and a biocompatible polymeric skeleton for sustainable drug release in response to the acidic OA condition. The high effectiveness of this targeted precision therapy is demonstrated comprehensively by both in vitro and vivo evidences.
Global health systems partnerships: A mixed methods analysis of HPV vaccine delivery network actors in Mozambique
Authors: Soi Caroline , Shearer Jessica , Chilundo Baltazar , Muchanga Vasco , Matsinhe Luisa , Gimbel Sarah , Sherr Kenneth 
Published: June 2020

Abstract
Global health partnerships have expanded exponentially in the last two decades with Gavi, the Vaccine Alliance considered the model’s pioneer and leader because of its vaccination programs’ implementation mechanism. Gavi, relies on diverse domestic and international partners to carry out its programs in low- and middle-income countries under a Partnership Engagement Framework (PEF). We harnessed an established partnership evaluation framework, to conduct an in-depth examination of Mozambique’s Gavi driven partnership network which delivered the human papillomavirus (HPV) vaccine during the demonstration phase. Methods We utilized mixed methods to assess five partnership dimensions. Qualitative tools gauged contextual factors, prerequisites, partner performance and practices while a social network analysis (SNA) survey measured the partnership structure and perceived added value in terms of effectiveness, efficiency and country ownership. The 40 key informants who were interviewed included frontline ministry of health workers, ministry of education staff and supporting partner organization members, of whom 34 participated in the social network analysis survey. Results SNA measures for partnership structure revealed a partnership network characterized by high overall connectivity. Reachability 100% and average distance 2.5 scores were high, features that are favorable for rapid and widespread diffusion of information that is needed for engaging and handling multiple implementation scales. High SNA effectiveness and efficiency measures for structural holes (85%) and low redundancy (30%) coupled with high mean perceived effectiveness (97.6%) and efficiency (79.5%) outcome scores were observed. Additionally, the tie strength average score of 4.1 on a scale of 5 denoted high professional trust. These are all markers of a partnership where disparate institutions and organizations worked in a collaborative environment in which each entity’s comparative advantage was leveraged. Lower perceived outcome scores for country ownership (24%) were found with the challenges of working with out-of-country partners being prominently cited by study participants as reasons. Conclusions While there is room for improvement on the country ownership aspects of the partnership, the expanded, diverse and inclusive collaboration of institutions and organizations that implemented the Mozambique HPV vaccine demonstration project was effective and efficient and we recommend that the country adapt a similar model during the national scale up.
Development and external validation of a nomogram for predicting the effect of tumor size on survival of patients with perihilar cholangiocarcinoma
Authors: Zhang Yaodong , Wu Zhengshan , Wang Xing , Li Changxian , Chang Jiang , Jiang Wangjie , Wang Hongwei , Wang Yirui , Li Xiangcheng 
Published: June 2020

Abstract
Background: The effect of tumor size on account of the long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff value of tumor size in PCCA and integrate tumor size with other prognostic factors into a nomogram to improve the predictive accuracy of the prognosis of patients with PCCA. Methods: 363 PCCA patients underwent surgical resection were extracted from the Surveillance, Epidemiology and End Results (SEER) database. X-tile program was used to identify the optimal cutoff value of tumor size. A nomogram including tumor size was established to predict 1-, 3- and 5-year cancer-specific survival (CSS) based on the independent risk factors chosen by Kaplan-Meier methods and multivariable cox regression models. The precision of the nomogram for predicting survival was validated internally and externally. Results: PCCA patients underwent surgical resection were classified into 1-19 mm, 20-33 mm and ³34 mm subgroup based on the optimal cutoff for tumor size in terms of CSS. And we noticed that more larger tumor size group had worse tumor grade, advanced T stage, more positive regional lymph nodes and more frequency vascular invasion. The nomogram according to the independent factors was well calibrated and displayed better discrimination power than 7 th Tumor-Node-Metastasis (TNM) stage systems. Conclusions: The results demonstrated that the larger the tumor size was, the worse the survival would be. The proposed nomogram, which outperforms the conventional TNM staging system, showed consistently reliability and clinically practicality for predicting the prognosis of PCCA patients.
Relationship between neuropsychology, clinical traits, psychopathology and attitudes towards change in eating disorders
Authors: Mata-Saenz Beatriz , Rodríguez-Cano Teresa , Muñoz-Martínez Victoria Eugenia , Beato-Fernández Luis 
Published: June 2020

Abstract
Background: The interest of research on the neuropsychological characteristics of eating disorders (EDs) has primarily focused on inhibitory control, set-shifting and central coherence, as well as attention bias and decision making. These neuropsychological aspects may also influence attitudes towards therapeutic change and be related to a more severe clinical status. The objective of this paper was to analyse the relationship of psychopathological and clinical variables with neuropsychological characteristics of patients with EDs and to determine possible influence of these variables on patients’ attitude towards change. Methods: An observational analytical cross-sectional study was performed. The participants were 74 consecutive outpatients who received treatment at an ED unit during a 6-month period. They were assessed using clinical (Psychiatric Status Rating Scale, modified) and neuropsychological tests (Letter Number Sequencing test; Stroop test; Symbol Digit Modalities Test; Rey-Osterrieth Complex Figure Test). They were asked to complete several self-report psychopathological questionnaires (Body Shape Questionnaire; Eating Disorders Inventory; Beck Depression Inventory; State-Trait Anxiety Inventory; Dissociative Experiences Scale; Attitudes Towards Change in Eating Disorders Scale), but 23 participants (31.08%) did not return them. Descriptive statistics and multivariate analysis were performed to study the relationships between clinical and psychopathological neuropsychological variables.Results: Nineteen patients (25.68%) were diagnosed with restricting anorexia nervosa (AN), 19 (25.68%) with purging AN, 14 with bulimia nervosa (18.92%), 9 with binge eating disorder (12.16%) and 13 with ED not otherwise specified (17.57%). There were no significant differences among the groups in the scores on neuropsychological tests. BMI was related to the majority of the neuropsychological scores. “Precontemplation” was related to copy time (B=3.56; 95% CI (0.82-6.29), p<0.01) and memory time (B=-2.31; 95% CI (-4.58-(-0.05)); p<0.05). “Contemplation” was related to copy time (B=1.43; 95% CI (0.42-2.45); p<0.01) and style (B= -14.01; 95% CI (-24.98-(3.04)); p<0.01). “Decision” was related to working memory (SpanLN), the quantitative copy score, order and style.Conclusions: In EDs, neuropsychological dysfunction could be associated with decreased motivation to change. Hence, a comprehensive therapeutic framework should be established with the aim of providing neurocognitive training in addition to conventional therapy. This approach could enhance acknowledgment of the problem and improve the decisional balance.
The Effect of Cognitive Behavioral Therapy for Insomnia in People with Type 2 Diabetes Mellitus, Pilot RCT Part II: Diabetes Health Outcomes
Authors: Alshehri Mohammed , Alothman Shaima A. , Alenazi Aqeel M. , Rucker Jason L. , Phadnis Milind A. , Miles John M. , Siengsukon Catherine F. , Kluding Patricia M. 
Published: June 2020

Abstract
Background: Previous studies have shown the negative impact of sleep disturbances, specifically insomnia symptoms, on glucose metabolism for people with type 2 diabetes (T2D). People with insomnia symptoms are at risk of poor glycemic control and suboptimal diabetes self-care behavior (DSCB). Investigating the impact of a safe and effective intervention for individuals with T2D and insomnia symptoms on diabetes’ health outcomes is needed. Therefore, the aim of this exploratory study is to examine the effects of Cognitive Behavioral Therapy for Insomnia (CBT-I) on glycemic control, DSCB, and fatigue. Methods: Twenty-eight participants with T2D and insomnia symptoms, after passing an eligibility criteria at a medical research center, were randomly assigned to CBT-I (n=14) or Health Education (HE; n=14). The CBT-I and HE groups received 6 weekly one-hour sessions. This Randomized Controlled Trial (RCT) used a non-inferiority framework to test the effectiveness of CBT-I. Validated assessments were administered at baseline and post-intervention to assess glycemic control, DSCB, and fatigue. A Wilcoxon signed-rank test was utilized to compare within-group changes from baseline to post-intervention. A Mann-Whitney test was utilized to measure the between-group differences. Linear regression was used to assess the association between the blood glucose level and the number of days in the CBT-I group. Results: The recruitment duration was from October 2018 to May 2019. A total of 13 participants completed the interventions in each group and are included in the final analysis. No adverse events, because of being a part of this RCT, were reported. CBT-I participants showed significantly greater improvement in glycemic control, DSCB, and fatigue. There was a significant association between the number of days in the CBT-I intervention with the blood glucose level before bedtime (B=-0.56, p=.009) and after awakening in the morning (B=-0.57, p=.007). Conclusions: This study demonstrated a clinically meaningful effect of CBT-I on glycemic control in people with T2D and insomnia symptoms. Also, CBT-I positively impacted daytime functioning, including DSCB and fatigue. Future research is needed to investigate the long-term effects of CBT-I on laboratory tests of glycemic control and to understand the underlying mechanisms of any improvements.Trial registration: Clinical Trials Registry (NCT03713996). Registered 22 October 2018, https://clinicaltrials.gov/ct2/show/NCT03713996
COVID-19: A scoping review
Authors: Berhe Brhane , Legese Haftom , Degefa Hagos , Adhanom Gebre , Gebrewahd Aderajew , Mardu Fitsum , Tesfay Kebede , Kahsu Getachew , Welay Miglas , Negash Hadush 
Published: June 2020

Abstract
Background: Globally, the novel coronavirus is a pandemic disease causing severe human infections. The severe acute respiratory syndrome 2 is causing severe and life-threatening complications. Methods: A scoping review was conducted following the methodological framework. In this scoping review, 70 records as of May 21, 2020, were included and discussed to better understand the current updates of the virus. PubMed, BioRxiv, MedRxiv, Global Health and google scholars were searched comprehensively for articles, preprints, grey literature, reports, conference proceedings and expert information. Studies conducted in human and published in the English language were included in the review. All the findings and statements of the review regarding the outbreak are based on published data.Results: We identified 408 records, of which 70 studies met the inclusion criteria. We synthesized the data from the included records and deep insights were extracted. The impact of the outbreak is worsening due to overcrowding, presence of asymptomatic carriers, scarcity of test kits, the immune escaping ability of the virus and lack of community awareness.Conclusions and recommendations: Due to the fast-spreading nature of the severe acute respiratory syndrome 2 the prevention and control strategies become challenging. It is imposing social, psychological, and socio-economic impacts. Adherence to physical distancing, quarantining suspects, using personal protective equipment, health education and introducing appropriate handwashing practices, avoiding contact with animals, improved control, and prevention strategies are recommended.
Correlation between immunity from BCG and the morbidity and mortality of COVID-19
Authors: Wickramasinghe Dakshitha , Wickramasinghe Nilanka , Kamburugamuwa Sohan Anjana , Arambepola Carukshi , Samarasekera Dharmabandhu N 
Published: June 2020

Abstract
Background To investigate the association between parameters indicating immunity from BCG at country level (presence of BCG vaccination policy, BCG coverage, age-specific incidence of tuberculosis(TB)) and the morbidity and mortality of COVID-19. Methods Country-specific data for COVID-19 cases and deaths, demographic details, BCG coverage and policy, age-specific TB incidence and income level were obtained. The crude COVID-19 cases and deaths per 100,000 population were calculated and assessed against the parameters indicating immunity from BCG using linear regression analysis. Results Univariate analysis identified higher income level of a country to be significantly associated with COVID-19 cases (p<0.0001) and deaths (p<0.0001) but not with its case fatality rate. The association between COVID-19 and TB was strongest for TB incidence in patients >65-years (Cases(rs=-0.785,p=0.0001)) and deaths (rs=-0.647,p=0.0001).Multivariate analysis identified the higher income level of a country and not having a universal BCG vaccination policy to affect the COVID-19 cases. The deaths were inversely affected by the presence of BCG vaccination policy and coverage; and positively by the TB incidence in patients >65-years. Conclusion Significant inverse correlations observed between cases and deaths of COVID-19 and BCG related parameters highlights immunity from BCG as a likely explanation for the variation in COVID-19 across countries.
Age-Structured Model for COVID-19: Effectiveness of Social Distancing and Contact Reduction
Authors: Kimathi Mark , Mwalili Samuel , Ojiambo Viona , Gathungu Duncan 
Published: June 2020

Abstract
Background: Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2. The disease has spread to almost every country in the world. Kenya reported its first case on 13th of March 2020. From 16th March 2020, the country instituted various social distancing strategies to reduce the transmission and flatten the epidemic curve. These strategies include school closure, dusk-to-dawn curfew, and travel restriction across counties, especially Nairobi, Mombasa and Kwale. An age-structured compartmental model was developed to assess the impact of non-pharmaceutical interventions on severity of infections, hospital demands and deaths. Methods: The population is divided into four age-groups and for each age-group there are seven compartments, namely: susceptible , exposed, asymptomatic, mild, severe, critical, death and recovered. The contact matrices between the different ages are integrated into an age-structured deterministic model via the force of infection. This model is represented by ordinary differential equations and solved using Runge–Kutta methods, with suitable model parameters. Simulation results for the unmitigated and mitigated scenarios were depicted, for the different age-groups. Results: The 45% reduction in contacts for 60-days period resulted to between 11.5-13% reduction of infections severity and deaths, while for the 190-days period yielded between 18.8-22.7% reduction. The peak of infections in the 60-days mitigation was higher and happened about 2 months after the relaxation of mitigation as compared to that of the 190-days mitigation, which happened just a month after mitigation were relaxed. Low numbers of cases in children under 15 years was attributed to low susceptibility of persons in this age-group. High numbers of cases are reported in the 15-29 years and 30-59 years age bands since these individuals have wider interaction spheres, and they form a significant percentage of Kenya population. Conclusion: Two mitigation periods, considered in the study, resulted to reductions in severe and critical cases, attack rates, hospital and ICU bed demands, as well as deaths, with the 190-days period giving higher reductions. The study revealed the age-dependency of the key health outputs.