bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical vestibular evoked myogenic potential testing for assessment of vestibular functions in cochlear implant patients
Authors: Qiao Xiao‐Feng , Li Xin , Wang Wei‐Xing , Zheng Wei , Li Tong‐Li 
Published: October 2019

AbstractThis study aims to investigate the vestibular function status of cochlear implant patients using cervical vestibular evoked myogenic potential (cVEMP) testing and estimate the effects of cochlear implants on vestibular function. The cVEMPs of 50 cochlear implant patients were measured preoperatively, and at one and six months postoperatively. Then, implanted ears and non‐implanted ears were compared in terms of p13/n23 wave response rates, latency, amplitude and threshold. Preoperatively, the binaural cVEMP response rate was 92%, while the cVEMP response rates of implanted ears vs. non‐implanted ears at postoperative one and six months were 24% vs. 80% and 52% vs. 82%, respectively. No significant difference between implanted and non‐implanted ears was found preoperatively, in terms of latent period, amplitude, or threshold. However, significant changes were found in amplitude and threshold for implanted ears after the operation, but not in latency. No significant postoperative change was found in amplitude, latent period, or threshold for non‐implanted ears. Significant differences between implanted and non‐implanted ears were found in both amplitude and threshold. Cochlear implants affect vestibular function, especially saccular function, and reduce the cVEMP amplitude and threshold of implanted ears.
Scrutinizing the basis of originality in divergent thinking tests: On the measurement precision of response propensity estimates
Authors: Forthmann Boris , Paek Sue Hyeon , Dumas Denis , Barbot Baptiste , Holling Heinz 
Published: October 2019

BackgroundThe originality of divergent thinking (DT) production is one of the most critical indicators of creative potential. It is commonly scored using the statistical infrequency of responses relative to all responses provided in a given sample.AimsResponse frequency estimates vary in terms of measurement precision. This issue has been widely overlooked and is addressed in the current study.Sample and methodSecondary data analysis of 202 participants was performed. A total of 900 uniquely identified responses were generated on three DT tasks and subjected to a 1‐parameter logistic model with a response as the unit of measurement which allowed for the calculation of response‐level conditional reliability (and marginal reliability as an overall summary of measurement precision).ResultsMarginal reliability of response propensity estimates ranged from .62 to .67 across the DT tasks. Unique responses in the sample (the basis for the classic uniqueness scoring) displayed the lowest conditional reliability (across tasks: ≈ .50). Reliability increased nonlinearly as a function of both the frequency of occurrence predicted by the model (conditional reliability) and sample size (conditional and marginal reliability).ConclusionsThis study indicates that the common practice of frequency‐based originality scoring with typical sample sizes (e.g., N = 100 to N = 200) yields unacceptable levels of measurement precision (i.e., in particular for highly original responses). We further offer recommendations to mitigate the lack of measurement precision of frequency‐based originality scores for DT research.
Behaviour of endangered European eels in proximity to a dam during downstream migration: Novel insights using high accuracy 3D acoustic telemetry
Authors: Trancart Thomas , Carpentier Alexandre , Acou Anthony , Danet Valentin , Elliott Sophie , Feunteun Éric 
Published: October 2019

AbstractRiver infrastructures such as weirs, hydropower stations or water reservoirs represent obstructions to migration for diadromous fish. Knowledge of accurate behaviour of fish in front of such structures is required to protect migrants from hazardous areas, guide them towards safe passage or adapt structure to improve the escapement. We developed and made available a method to process acoustic telemetry data based on Time Difference Of Arrival analysis to accurately locate tagged fish. Improved accuracy allows the detection of escape routes and description of dam‐crossing tactics. Sixteen tagged eels were tracked with high accuracy (1–2 m) and ~1 location min−1 frequency during their exploration period on reaching the dam. Two migration routes (spillways and bottom compensation flow pipe) were used by 77% and 23% of eels respectively. Spillways were the preferred route, but a median of 16 days were required to pass the dam versus 1.1 days via the compensation pipe. A minimal water crest of 40 cm was required for passage via spillways. Eels passing through the compensation pipe were exclusively nocturnal and mainly explored the bottom of the dam. Eels passing through spillways explored the whole dam area by night and day, and were not attracted to the compensation pipe entrance. With global warming, more frequent drought periods are expected, potentially leading to decreased opportunities for eels to migrate across safer dams by spillways. To conserve this endangered species, dam management strategies that account for expected hydrologic conditions and distinct exploration behaviours are needed.
Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcumin
Authors: Cozza Giorgio , Zonta Francesca , Dalle Vedove Andrea , Venerando Andrea , Dall'Acqua Stefano , Battistutta Roberto , Ruzzene Maria , Lolli Graziano 
Published: October 2019

Protein kinase CK2 is an antiapoptotic cancer‐sustaining protein. Curcumin, reported previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2 active site and rapidly degrades in solution generating various ATP‐mimetic inhibitors; with a detailed comparative analysis, by means of both protein crystallography and enzymatic inhibition, ferulic acid was identified as the principal curcumin degradation product responsible for CK2 inhibition. The other curcumin derivatives vanillin, feruloylmethane and coniferyl aldehyde are weaker CK2 inhibitors. The high instability of curcumin in standard buffered solutions flags this compound, which is included in many commercial libraries, as a possible source of misleading interpretations, as was the case for CK2. Ferulic acid does not show any cytotoxicity and any inhibition of cellular CK2, due to its poor cellular permeability. However, curcumin acts as a prodrug in the cellular context, by generating its degradation products inside the treated cells, thus rescuing CK2 inhibition and consequently inducing cell death. Through the intracellular release of its degradation products, curcumin is expected to affect various target families; here, we identify the first bromodomain of BRD4 as a new target for those compounds.DatabaseStructural data are available in the PDB database under the accession numbers 6HOP (CK2α/curcumin), 6HOQ (CK2α/ferulic acid), 6HOR (CK2α/feruloylmethane), 6HOT (CK2α/ferulic aldehyde), 6HOU (CK2α/vanillin) and 6HOV (BRD4/ferulic acid).
Overview of the main challenges in shared decision making in a multicultural and diverse society in the intensive and critical care setting
Authors: Giuliani Enrico , Melegari Gabriele , Carrieri Francesca , Barbieri Alberto 
Published: October 2019

AbstractBackgroundIn shared decision making, health care professionals and patients collaborate in making health‐related choices. This process is based on autonomy and constitutes one to the elements of patient‐centered care. However, there are situations where shared decision making is more difficult, if not impossible, due to barriers, which may be related to language, culture, education, or mental capacity and external factors like the state of emergency or the availability of alternative sources of information.AimThe aim of this paper is to identify some of the main obstacles to the adoption of shared decision making in an intensive and critical care scenario and discuss potential ways to facilitate its implementation.MethodsWe conducted a literature review on shared decision making from the perspective of intensive and critical care specialists.DiscussionAlthough the health care context is complex and the variety of situation that can arise makes it impossible to prepare professionals for every occurrence, shared decision making process should be structured at an organization level, engaging health care professionals, experts of communication, and patient representatives coming from different cultural backgrounds, languages, and education to assemble for all the main procedures, where shared decision making is involved, the specific information packages health care professionals will use in order to guide them through the process and ensuring all patients receive a comparable level of engagement. Shared decision making should not become a hindrance for the health care professional but on the contrary a way to strengthen their relationship with the patient.ConclusionThe implementation of the shared decision making approach at an organization‐wide level improves its quality and effectiveness.
PVA/starch/propolis/anthocyanins rosemary extract composite films as active and intelligent food packaging materials
Authors: Mustafa Pakeeza , Niazi Muhammad B. K. , Jahan Zaib , Samin Ghufrana , Hussain Arshad , Ahmed Tahir , Naqvi Salman R. 
Published: October 2019

AbstractActive and intelligent food packaging films has taken more importance over conventional packaging. The aim of this study was to develop active and intelligent food packaging films based on bio‐degradable polymers like polyvinyl alcohol and starch, incorporated with natural additives, that is, propolis extract (PE) and Anthocyanin. Boric acid was used as a cross‐linker. The results proved the compatibility of films mixture. The mechanical strength was also measured and highest value was achieved 6.1 MPa for films containing 20% PE. Moreover, the maximum zone of inhabitation, that is, 21 and 15 mm, was also achieved at same composition against Escherichia coli and methicillin‐resistant Staphylococcus aureus, respectively. Furthermore, all films had shown great color response against different pH ranging from 2 to 14. Finally, food spoilage test was performed using pasteurized milk. Films responded visibly by changing color and protected milk from spoilage. Hence, formulated bio‐degradable active and intelligent films can be used as food packaging material.
Reducing dietary protein concentrations and replacing fish meal with porcine meat and bone meal do not affect growth or feed conversion of pond‐raised fingerling channel catfish, Ictalurus punctatus
Authors: Li Menghe H. , Wise David J. , Mischke Charles C. , Kumar Ganesh , Greenway Terrence E. , Tiwari Ambika , Lucas Penelope M. 
Published: October 2019

AbstractThis study evaluated dietary protein concentrations and replacing fish meal with porcine meat and bone meal (PMB) for pond‐raised fingerling channel catfish, Ictalurus punctatus. Three diets were formulated to have 28, 32, or 35% protein using soybean meal, cottonseed meal, and fish meal as the main protein sources, respectively. A fourth diet contained 32% protein with fish meal being replaced with PMB. Analyzed protein concentrations were 29.7, 31.9, 34.4, and 31.1% on 90% dry matter basis, respectively. Small fingerlings (average initial weight: 2.0 g/fish) were stocked in 20 earthen ponds (0.04 ha) at 172,970 fish/ha and were fed once daily to apparent satiation for 98 days. There were no significant differences in total diet fed, gross yield, final weight, feed conversion ratio, survival, or condition factor among diets. There were also no significant differences in ammonia‐N, nitrite‐N, chlorophyll a, or desirable zooplankton concentrations in pond water of fish receiving different diets. Results show that a diet containing about 30% protein can support optimum growth of pond‐raised channel catfish fingerlings of 2 g and larger in fertilized ponds fed once daily to apparent satiation. PMB can completely replace fish meal in a 32% protein diet. Economic analysis suggests considerable cost savings by replacing fish meal with PMB and reducing protein concentrations in channel catfish fingerling diets.
Epidemiology, utilisation of healthcare resources and outcome of invasive fungal diseases following paediatric allogeneic haematopoietic stem cell transplantation
Authors: Linke Christina , Ehlert Karoline , Ahlmann Martina , Fröhlich Birgit , Mohring Daniela , Burkhardt Birgit , Rössig Claudia , Groll Andreas H. 
Published: October 2019

SummaryBackgroundEpidemiology and management practices of invasive fungal diseases (IFD) after allogeneic haematopoietic stem cell transplantation (HSCT) are a subject of constant change. We investigated the contemporary incidence, diagnostics, antifungal management and outcome at a major paediatric transplant centre in Germany.MethodsThe single‐centre retrospective observational study included all paediatric allogeneic HSCT patients (pts) transplanted between 2005 and 2015. Patient‐related data were assessed up to 365 days post‐transplant. The primary endpoint was the incidence of possible, probable and proven IFDs. Secondary endpoints included diagnostics and antifungal treatment; analysis of risk factors; and overall survival with the last follow‐up in January 2017.ResultsA total of 221 first (196), second (21) or third (4) procedures were performed in 200 pts (median age: 9 years, range, 0.5‐22) for leukaemia/lymphoma (149) and non‐malignant disorders (72). Prophylaxis was administered in 208 HSCT procedures (94%; fluconazole, 116, mould‐active agents, 92). At least one computed tomography scan of the chest was performed in 146, and at least one galactomannan antigen assay in 60 procedures. There were 15 cases of proven (candidemia, 4; aspergillosis, 4) or probable (aspergillosis, 7) IFDs, accounting for an incidence rate of 6.8%. Overall mortality at last follow‐up was 30%; the occurrence of proven/probable IFDs was associated with a reduced survival probability (P < .001).ConclusionMorbidity and mortality from IFDs at our institution were consistent with data reported from other centres. Utilisation of healthcare resources for prevention, diagnosis and management of IFDs was considerable.
Comparison of bronchial and nasal allergen provocation in children and adolescents with bronchial asthma and house dust mite sensitization
Authors: Fischl Anna , Eckrich Jonas , Passlack Vanessa , Klenke Sara-Kristin , Hartmann Desiree , Herrmann Eva , Schulze Johannes , Zielen Stefan 
Published: October 2019

AbstractBackgroundBronchial allergen provocation (BAP) is an established tool for the diagnosis of allergy in patients with asthma, but its use is limited by the potential risk of severe asthmatic reactions. Nasal provocation testing (NPT) may be an alternative safe method and does not require sophisticated equipment.ObjectiveThe aim of this prospective study was to evaluate the concordance of both methods in patients with asthma and house dust mite (HDM) sensitization.MethodsA total of 112 patients with HDM sensitization underwent BAP and had the following parameters analysed: decrease in FEV1, exhaled NO, and total and specific IgE. Within 12 weeks, NPT with HDM was performed in 74 patients with a median age of 9 years (range, 5‐16 years). The results were evaluated using the Lebel score which quantifies major symptoms like rhinorrhea, nasal obstruction, sneezes and minor symptoms, such as pruritus, conjunctivitis and pharyngitis.ResultsFifty‐seven of 74 patients had an early asthmatic reaction, of which 41 were identified using the Lebel score. The Lebel score had a sensitivity of 71.9% and a positive predictive value (PPV) of 89.1%. In addition, an eNO ≥ 10 ppb (AUC 0.78), a specific IgE Dermatophagoïdes pteronyssinus ≥ 25.6 kU/L (AUC 0.76) and a specific IgE Dermatophagoïdes farinae ≥ 6.6 kU/L (AUC 0.78) were good predictors of an early asthmatic reaction.ConclusionA sequential use of NPT prior to BAP is justified to establish the relevance of HDM allergy. In patients with a negative NPT, BAP is still recommended to rule out a HDM‐induced asthmatic reaction.
Large‐scale GWAS in sorghum reveals common genetic control of grain size among cereals
Authors: Tao Yongfu , Zhao Xianrong , Wang Xuemin , Hathorn Adrian , Hunt Colleen , Cruickshank Alan W. , van Oosterom Erik J. , Godwin Ian D. , Mace Emma S. , Jordan David R. 
Published: October 2019

SummaryGrain size is a key yield component of cereal crops and a major quality attribute. It is determined by a genotype’s genetic potential and its capacity to fill the grains. This study aims to dissect the genetic architecture of grain size in sorghum. An integrated genome‐wide association study (GWAS) was conducted using a diversity panel (n = 837) and a BC‐NAM population (n = 1421). To isolate genetic effects associated with genetic potential of grain size, rather than the genotype’s capacity to fill the grains, a treatment of removing half of the panicle was imposed during flowering. Extensive and highly heritable variation in grain size was observed in both populations in 5 field trials, and 81 grain size QTL were identified in subsequent GWAS. These QTL were enriched for orthologues of known grain size genes in rice and maize, and had significant overlap with SNPs associated with grain size in rice and maize, supporting common genetic control of this trait among cereals. Grain size genes with opposite effect on grain number were less likely to overlap with the grain size QTL from this study, indicating the treatment facilitated identification of genetic regions related to the genetic potential of grain size. These results enhance understanding of the genetic architecture of grain size in cereal, and pave the way for exploration of underlying molecular mechanisms and manipulation of this trait in breeding practices.
Population structure and species delimitation of rice white tip nematode, Aphelenchoides besseyi (Nematoda: Aphelenchoididae), in China
Authors: Xu X. , Qing X. , Xie J. L. , Yang F. , Peng Y. L. , Ji H. L. 
Published: October 2019

Aphelenchoides besseyi is a major nematode pathogen in rice known as the causal agent of white tip disease. In the present study, A. besseyi was recovered from 32 seed samples collected from the major rice‐growing regions in China. Nine mitochondrial COI haplotypes and 95 ITS genotypes were identified, suggesting a high genetic diversity and endemism level of A. besseyi in China. Therefore, A. besseyi is likely to have experienced a long history of host–parasite coevolution in China, rather than being recently introduced from other countries. The results of population structure analysis indicated the presence of four clusters within Chinese A. besseyi, but these did not correspond to their geographic distribution. Haplotype H2 was found to be the most widespread. Haplotypes H9 and H13 were most genetically divergent and have been recognized as two cryptic species by molecular species delimitation methods, and with limited support from morphometric measurements. The COI‐based phylogeny suggested the ability to parasitize rice has independently evolved at least four times in the genus Aphelenchoides.
Activation of goat primordial follicles in vitro: Influence of alginate and ovarian tissue
Authors: Correia Hudson H. V. , Lima Laritza F. , Sousa Francisca Geovania C. , Ferreira Anna Clara A. , Cadenas Jesus , Paes Victor M. , Alves Benner G. , Shikanov Ariella , Figueiredo José Ricardo 
Published: October 2019

AbstractThe present study aimed to evaluate the effect of three culture systems on caprine primordial follicle activation in vitro: follicles cultured either in the isolated form within alginate (Isolated follicles + Alginate treatment), or enclosed in ovarian tissue (in situ), with or without alginate (Fragment + Alginate, and Fragment alone treatments, respectively). After culture, the Isolated follicles + Alginate treatment presented a percentage of morphologically normal follicles (MNF) similar to both the non‐cultured control and the Fragment Alone treatments. Nevertheless, Fragment + Alginate treatment showed a significant reduction in the number of MNF when compared to the other treatments. Regarding follicle development, our results showed that regardless of the alginate, the presence of ovarian tissue limited primordial follicle activation during in vitro culture. Remarkably, the Isolated primordial follicle + Alginate treatment was the only one that significantly promoted follicle activation and increased both follicle and oocyte diameters during IVFC, pointing out a higher cell proliferation. In conclusion, the presence of ovarian tissue with or without alginate limited follicle development (activation) after culture. Nevertheless, when primordial follicles were isolated and encapsulated in alginate they presented suitable survival rates, higher rates of follicle activation and continued to grow throughout the culture period.
Reviewer Acknowledgements
Authors: Smith Robert 
Published: October 2019

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 7, Number 10S Achara Jivacate, RATCH Group Public Company Limited, ThailandFroilan D. Mobo, Philippine Merchant Marine Academy, PhilippineGianpiero Greco, University of Study of Bari, ItalyIntakhab Khan, King Abdulaziz University, Saudi ArabiaJohn Cowan, Edinburgh Napier University, UKJon S. Turner, Missouri State University, USAMan-fung Lo, The Hong Kong Polytechnic University, Hong KongMatt Varacallo, University of Kentucky, USAMehmet Galip Zorba, Akdeniz University, TurkeyMelike Özüdoğru, Manisa Celal Bayar University, TurkeyRichard Penny, University of Washington Bothell, USASamah El-Sakka, Suez University, EgyptSandro Sehic, Oneida BOCES, USASenem Seda Şahenk Erkan, Marmara University, TurkeyStamatis Papadakis, University of Crete, GreeceVjacheslav Ivanovich Babich, Luhansk Taras Shevchenko National University, Ukraine Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
Experimental Comparison of Two Integer Valued Iterative Learning Control Approaches at a Stator Cascade
Authors: Arnold Florian , Neuhäuser Karl , King Rudibert 
Published: October 2019

Abstract
Experimental and simulative investigations have shown that active flow control (AFC) is an effective method to influence flow conditions within a compressor. This can be used for different cases like mitigating flow separation or to ensure a uniform flow throughout a compressor stage. Control performance can be improved by making use of a cyclic character found in the rotor/stator interaction or found in new gas turbine setups exploiting cycling combustion. To this end, iterative learning control (ILC) is applied. To achieve a fast actuation, irrespective of the implemented control method, solenoid valves should be installed instead of proportional valves. Unfortunately, the binary character of these valves does not allow the application of conventional control methods, e.g., real-valued ILC. This contribution presents two options to handle the binary control domain in the context of an ILC. Both approaches are tested in a simulation study first to analyze the behavior. Then they are applied to a real test rig featuring a linear stator cascade.