bluuebunny/crossref_metadata_2025_split huggingface dataset:
An internet-based survey exploring the awareness of febrile neutropenia in patients with malignant lymphoma
Authors: Takamatsu Yasushi , Yoshida Isao , Yoshida Minoru 
Published: January 2020

Abstract
Purpose
Febrile neutropenia (FN) is associated with infection-related mortality and a reduction of relative dose intensity during chemotherapy of malignant lymphoma. To prevent deaths and recover the attenuated efficacy of chemotherapies caused by FN, guidelines for the management of FN are published. The aim of this study is to clarify the degree to how much patients understand the FN.

Methods
An internet-based survey was employed to investigate the awareness of FN in Japanese patients who had received chemotherapies for malignant lymphoma.

Results
A total of 105 subjects were enrolled, of whom 64 (61.0%) received ambulatory treatment and 41 (39.0%) received primarily inpatient services. Sixty-four (61.0%) remembered receiving explanations of FN and 61 (95.3%) understood FN very well or almost well. Respondents who reported understanding received explanations from multiple medical staff that were similar to those from single medical staff. A total of 31 (29.5%) experienced FN and 17 of them developed FN at home. Only 8 (47.1%) visited or made contact with their hospitals within 3 h after onset at home.

Conclusions
Explanatory procedures need to be addressed, since subjects’ levels of understanding were not proportionate to the number of elucidators. Although medical professionals made preliminary explanations, in fact, no more than half of those respondents who developed FN at home had made contact to their hospitals immediately. In conclusion, these results suggest that medical professionals should make more effort to lead patients to an understanding of the proper correspondences in case of FN onset.
Glucosinolate Abundance and Composition in Brassicaceae Influence Sequestration in a Specialist Flea Beetle
Authors: Yang Zhi-Ling , Kunert Grit , Sporer Theresa , Körnig Johannes , Beran Franziska 
Published: January 2020

AbstractThe horseradish flea beetlePhyllotreta armoraciaeexclusively feeds on Brassicaceae, which contain glucosinolates as characteristic defense compounds. Although glucosinolates are usually degraded by plant enzymes (myrosinases) to toxic isothiocyanates after ingestion,P. armoraciaebeetles sequester glucosinolates. Between and within brassicaceous plants, the glucosinolate content and composition can differ drastically. But how do these factors influence sequestration inP. armoraciae? To address this question, we performed a five-day feeding experiment with threeArabidopsis thalianalines that differ four-fold in glucosinolate content and the composition of aliphatic and indolic glucosinolates. We quantified the amounts of ingested, sequestered, and excreted glucosinolates, and analyzed the changes in glucosinolate levels and composition in beetles before and after feeding onArabidopsis.P. armoraciaeaccumulated almost all ingested glucosinolate types. However, some glucosinolates were accumulated more efficiently than others, and selected glucosinolates were modified by the beetles. The uptake of new glucosinolates correlated with a decrease in the level of stored glucosinolates so that the total glucosinolate content remained stable at around 35 nmol/mg beetle fresh weight. Beetles excreted previously stored as well as ingested glucosinolates fromArabidopsis, which suggests thatP. armoraciaeregulate their endogenous glucosinolate level by excretion. The metabolic fate of ingested glucosinolates, i.e. the proportions of sequestered and excreted glucosinolates, depended on glucosinolate type, content, and composition in the food plant. Overall,P. armoraciaesequestered and excreted up to 41% and 31% of the total ingested aliphatic and indolic glucosinolates fromArabidopsis, respectively. In summary, we show that glucosinolate variability in Brassicaceae influences the composition but not the level of sequestered glucosinolates inP. armoraciaebeetles.
Mean platelet volume-to-lymphocyte ratio: a novel biomarker associated with overall survival in patients with nonmetastatic clear cell renal cell carcinoma treated with nephrectomy
Authors: Życzkowski Marcin , Kaletka Zbigniew , Rajwa Pawel , Rempega Grzegorz , Stelmach Paweł , Bogacki Rafał , Łach-Wojnarowicz Olga , Paradysz Ewa 
Published: January 2020

Abstract
Introduction
Renal cell carcinoma is a highly aggressive malignancy that causes significant morbidity and mortality. The rising number of newly diagnosed renal tumors results in a great need to search for new preoperative markers to evaluate the course of the disease and to help select patients who would benefit the most from additional postoperative care. The aim of our study was to evaluate the prognostic value of mean platelet volume-to-lymphocyte ratio (MPVLR) in patients undergoing nephrectomy for nonmetastatic clear cell renal cell carcinoma (ccRCC).

Materials and methods
A total number of 344 patients with proven nonmetastatic ccRCC treated with radical or partial nephrectomy at our institution between January 2003 and December 2012 were included in our analysis. Based on the optimal cut-off value of MPVLR, which was determined by the receiver operating characteristic curve, our study population was divided into two groups, with low and high MPVLR. Differences in overall survival between groups were compared using the Kaplan–Meier method with log-rank testing. The Cox proportional hazards regression model was applied to perform univariate and multivariate analysis.

Results
Study subjects with high MPVLR were older and had more advanced tumors. Tumor necrosis and higher TNM stages were also more prevalent in this group of patients. Mortality in patients with high MPVLR was significantly higher than in patients with low MPVLR. In the multivariate analysis, after adjustment for pathological and clinical covariates, high MPVLR (≥ 3.61) was independently associated with higher long-term overall mortality in nonmetastatic ccRCC patients.

Conclusion
MPVLR is an easily obtainable prognostic marker for overall survival in nonmetastatic ccRCC patients treated with nephrectomy.
Non-isothermal Phase-Field Modeling of Heat–Melt–Microstructure-Coupled Processes During Powder Bed Fusion
Authors: Yang Yangyiwei , Kühn Patrick , Yi Min , Egger Herbet , Xu Bai-Xiang 
Published: January 2020

AbstractModeling and simulation of powder bed fusion (PBF) remain a great challenge due to the sophisticated and interactive nature of underlying physics.
A unified scenario considering interactions among the heat transfer, melt flow dynamics and microstructure evolution (noted as “heat–melt–microstructure-coupled processes”) is therefore essential for a thermodynamically consistent description and thus reliable microstructure prediction. In contrast to the state of the art, where either individual aspects are considered or the thermal history is taken as input from separate numerical scheme, we propose in this work a unified non-isothermal phase-field model for the heat–melt–microstructure-coupled processes during PBF.
Simulations on a stainless steel 316L powder bed demonstrate that the model can reproduce well-observed features, but also help to discover new in-process phenomena and reveal the mechanism of the defect formation.
Based on massive simulation results, we also present the densification map with respect to beam power and scan speed, and have classified the regions of the parameter combination by the distinct resultant morphology.
Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42
Authors: Jäkel Lieke , Biemans Elisanne A.L.M. , Klijn Catharina J.M. , Kuiperij H. Bea , Verbeek Marcel M. 
Published: January 2020

AbstractThe amyloid-β 43 (Aβ43) peptide has been shown to be abundantly expressed in Alzheimer’s disease plaques, whereas only relatively low levels have been demonstrated in cerebral amyloid angiopathy (CAA). To better understand this discrepant distribution, we studied various biochemical properties of Aβ43, in comparison with Aβ40 and Aβ42. We assessed the interaction of Aβ43 with the three apoE isoforms (apoE2, apoE3, and apoE4) using SDS-PAGE/Western blotting and ELISA, aggregation propensity using thioflavin T assays, and cytotoxicity towards cerebrovascular cells using MTT assays. We found that Aβ43 did not differ from Aβ42 in its interaction with apoE, whereas Aβ40 had a significantly lower degree of interaction with apoE. At a molar ratio of 1:100 (apoE:Aβ), all apoE isoforms were comparably capable of inhibiting aggregation of Aβ40 and Aβ42, but not Aβ43. All Aβ variants had a concentration-dependent negative effect on metabolic activity of cerebrovascular cells. However, the degree of this effect differed for the three Aβ isoforms (Aβ40 > Aβ42 > Aβ43), with Aβ43 being the least cytotoxic peptide towards cerebrovascular cells. We conclude that Aβ43 has different biochemical characteristics compared with Aβ40 and Aβ42. Aggregation of Aβ43 is not inhibited by apoE, in contrast to the aggregation of Aβ40 and Aβ42. Furthermore, cerebrovascular cells are less sensitive towards Aβ43, compared with Aβ40 and Aβ42. In contrast, Aβ43 neither differed from Aβ42 in its aggregation propensity (in the absence of apoE) nor in its apoE-binding capacity. Altogether, our findings may provide an explanation for the lower levels of Aβ43 accumulation in cerebral vessel walls.
Determination of Free Tryptophan in Beer Samples by Capillary Isotachophoretic Method
Authors: Jastrzębska Aneta , Kowalska Sylwia , Szłyk Edward 
Published: January 2020

AbstractTryptophan is essential amino acid and precursor for many neurotramsmiters that must be obtained from dietary proteins. However, its free form is easily absorbed and could increase the availability of this amino acid to the brain. Because of free tryptophan interaction with human health simple, eco-friendliness and low-cost method of determination are still needed. In this study, new and simple procedure for free tryptophan determination using capillary isotachophoresis is discussed. The method validation pointed good linearity, satisfactory selectivity, accuracy (recoveries varied from 98.4 to 100.1%), intra- and inter-day precision (coefficent of variation was < 5% for each standard solution and < 6% for real samples) and no matrix effect. The proposed procedure was successfully applied to analyse free tryptophan in beer samples and found contents varied from not detected to 40.74 ± 0.27 mg L−1. The obtained results were compared with chromatographic determination after derivatization with 2-chloro-1,3-dinitro-5-(trifluoromethyl)benzene and pointed better selectivity and accuracy of isotachophoretic procedure with similar precision. Due to the simplicity and flexibility, the proposed procedure is suitable for tryptophan analysis in complex matrices.
Identifying local differences with fused-MCP: an apartment rental market case study on geographical segmentation detection
Authors: Inoue Ryo , Ishiyama Rihoko , Sugiura Ayako 
Published: January 2020

AbstractAs the variety and quality of spatial data increase in recent times, the potential to analyze local characteristics based on spatial data is getting stronger. Previous spatial analysis methods structuralize the spatial autocorrelation of data by the distances between data observation points and the contiguity of the data-observed regions. It is significant for the estimation of global characteristics of spatial data. However, these approaches are not suitable for identifying local differences from the data since they assume a smooth spatial autocorrelation structure. Generalized fused lasso, which can detect local differences in spatial data, has been proposed in machine learning studies. Its limitation is that the estimated parameters are biased toward zero; however, methods that overcome the limitation have also been proposed. Fused-MCP is one of those methods and is expected to be useful in spatial analyses. This study applies fused-MCP to spatial analyses. As an example of spatial analyses based on fused-MCP, this study analyzes the structure of geographical segmentation of the real estate market in central Tokyo. Fused-MCP is utilized to extract areas where the valuation standard is the same. The results reveal that the geographical segmentation displays hierarchal patterns. Specifically, the market is divided by municipalities, railway lines and stations, and neighborhoods. The case study confirmed the applicability of fused-MCP to spatial analyses.
Rapid Fabrication of Bio-inspired Antireflection Film Replicating From Cicada Wings
Authors: Wang Ze , Li Bo , Feng Xiaoming , Jiao Zhibin , Zhang Junqiu , Niu Shichao , Han Zhiwu , Ren Luquan 
Published: January 2020

AbstractInspired by cicada wings, a flexible film with self-cleaning and broadband antireflection properties was fabricated with a rapid, straightforward and cost-effective method. The cicada wing was selected as the original template, and a polymethyl methacrylate (PMMA) negative replica was obtained by evaporation solvent process. The original template was directly peeled off. Subsequently, the polydi-methylsiloxane (PDMS) was spread in the as-prepared PMMA negative replica. After curing and peeling processes, the PDMS positive replica was manufactured successfully. The morphologies and performances of cicada wings were perfectly inherited by the PDMS positive replica. What is more, the excellent optical property of cicada wing was investigated experimentally and theoretically. Compared with flat PDMS film, the average reflectivity of structural PDMS film was reduced from 9% to 3.5% in the wavelength range of 500 nm–900 nm. These excellent antireflection properties of bio-inspired antireflection film can be attributed to the nanostructures which achieve a gradient refractive index between air and the materials, and the mechanism of the antireflection properties was revealed via effective medium theory. Besides, the bio-inspired broadband antireflective film exhibited superhydrophobic property after the surface treatment (a 152.1°water contact angle), and it also displayed satisfactory flexibility. This work provided a universal method to fabricate the exquisite biological structures, realizing the transfer of structure and function. Moreover, the multifunctional antireflection film exhibited the potential value for applications in optical communications, flexible display screens, and anti-dazzle glasses.
Inklusiver Sachunterricht zwischen Kind- und Materialorientierung – Mediennutzung und Motive der Medienauswahl im Fokus einer explorativen Lehrkräftebefragung
Authors: Schroeder René 
Published: January 2020

ZusammenfassungDer vorliegende Beitrag referiert empirische Befunde einer zweiphasigen Lehrkräftebefragung zur Sachunterrichtpraxis in Nordrhein-Westfalen. Der Fokus der dargestellten Ergebnisse liegt hierbei auf der Mediennutzung sowie den damit verbundenen Motiven zur Medienauswahl der Lehrkräfte im inklusiven Sachunterricht. Die vorliegenden Daten wurden im Rahmen eines integrierten Mixed-Methods-Designs, bestehend aus einer teilstandardisierten Fragebogenerhebung (n = 80) sowie vertiefenden Experteninterviews (n = 10) mit einer Teilstichprobe der zuvor befragten Sachunterrichtslehrkräfte, gewonnen. Ergebnisse aus der statistischen wie auch qualitativ-inhaltsanalytischen Auswertung der quantitativen und qualitativen Daten werden mit Schwerpunkt auf die Mediennutzung sowie möglichen Einflussfaktoren hierauf analysiert und interpretiert. Dies geschieht vor dem Hintergrund der besonderen Bedeutung, die einem vielfältigen und differenzierten Medien- und Materialangebote für ein Kind orientiertes Lernen aus Perspektive einer inklusiven Sachunterrichtdidaktik zugeschrieben wird. Ebenso wird reflektiert, inwieweit sich eine aus bereits vorliegenden Studien erkennbare Materialorientierung von Sachunterrichtlehrkräften, bei der didaktisch-methodische Entscheidungen durch verfügbare Medien und Materialien determiniert werden, auch in den eigenen Befunden widerspiegelt. Im Ausblick werden mögliche Schlussfolgerungen für einen inklusiven Sachunterricht hinsichtlich zukünftiger fachdidaktischer Forschung zu barrierefreien Lehr-Lernmaterialien abgeleitet.
Effects of using curriculum-based measurement (CBM) for progress monitoring in reading and an additive reading instruction in second classes
Authors: Anderson Sven , Jungjohann Jana , Gebhardt Markus 
Published: January 2020

AbstractIn this study, poor readers in second school year were selected from three schools (n = 32). Their reading skills were surveyed weekly using a CBM instrument over one school semester. Furthermore, they were supported by a five-week reading fluency instruction. The majority of students increased their weekly learning growth in regular teaching and in the phase with the additive instruction. The weekly learning growth was higher in the phase with the additive instruction in reading syllables (b = 0.69), reading words (b = 0.44) and reading comprehension at sentence level (b = 0.45) than without (reading syllables: b = 0.49; reading words: b = 0.18; reading comprehension: b = 0.30). Based on the results of this study, the benefit of CBM for adaptive reading instruction will be discussed.
Understanding Infidelity Forgiveness: An Application of Implicit Theories of Relationships
Authors: Thompson Ashley E. , Capesius Dallas , Kulibert Danica , Doyle Randi A. 
Published: January 2020

Abstract
Two studies were conducted to identify variables associated with hypothetical infidelity forgiveness and promote forgiveness by manipulating implicit theories of relationships (ITRs; destiny/growth beliefs). Study 1 assessed the relationship between the type of behaviour, sex of the forgiver, ITRs and infidelity forgiveness. Study 2 investigated the causal relationship between ITRs and infidelity forgiveness (including attachment insecurity as a moderator). Results revealed that male participants forgave a partner's infidelity to a greater extent than female participants and that solitary behaviours were rated as most forgivable, followed by emotional/affectionate and technology/online behaviours, and sexual/explicit behaviours as least forgivable. Male participants (not female participants) induced to endorse growth beliefs forgave a partner's emotional/affectionate and solitary infidelity to a greater extent than those induced to endorse destiny beliefs; attachment insecurity moderated this relationship. These results have important implications for researchers and practitioners working with couples in distress.
Penicillium commune affects textural properties and water distribution of hard and extra-hard cheeses
Authors: Jurado Miguel , Vicente Carlos Javier 
Published: January 2020

AbstractWe analyzed the effects of growth of Penicillium commune, one of the most frequent fungal species associated with cheese, on the water diffusion and texture of hard and extra-hard cheeses. A total of 36 hard cheese blocks and 36 extra-hard cheese blocks were manufactured, salted at different levels (0.5, 1.25 and 2% w/w), and assigned to different treatments (control and inoculated). Cheese texture was analyzed using a penetration needle probe at 2 and 5 weeks after ripening. Firmness, defined as the maximum force detected in the penetration probe, was higher in both hard and extra-hard inoculated cheese blocks compared with the control. In addition, the presence of fungal growth on cheese rind increased the total work of penetration (a measure of resistance to probe penetration), but only in extra-hard cheeses, suggesting that the moisture of cheese might be affecting the growth capacities and performance of P. commune. The change in textural properties of cheeses was linked to desiccation of the upper 0.5-cm rind layer mediated by P. commune.
Digenean Holostephanus (Trematoda: Digenea: Cyathocotylidae) metacercariae in common carp (Cyprinus carpio Linnaeus, 1758) muscle: zoonotic potential and sensitivity to physico-chemical treatments
Authors: Sándor D. , Gyöngy M. , Nyeste K. , Czeglédi I. , Székely C. , Buchmann K. , Cech G. 
Published: January 2020

Abstract
Metacercariae of various species within the genus Holostephanus Szidat, 1936 (Trematoda: Digenea: Cyathocotylidae) occur in muscles of both farmed and wild fish, including common carp (Cyprinus carpio Linnaeus, 1758). The life cycle includes a snail as first intermediate host, fish as second intermediate host and birds or mammals as final hosts. We studied the zoonotic potential and the viability of Holostephanus metacercariae from common carp following exposure to various physical and chemical treatments. Muscle tissue samples of common carp specimens from a fish farm in the north-eastern part of Hungary were examined and metacercariae recovered. The zoonotic potential was evaluated experimentally by using small mammals as models (albino mice, n = 2; and Syrian hamsters, n = 4) infected per os with Holostephanus cysts. Parallelly, Metagonimus metacercariae were used as positive controls. We could not confirm the zoonotic potential of Holostephanus metacercariae as they did not survive in the mammalian intestine whereas Metagonimus metacercariae developed to the adult stage. We assessed the viability of metacercariae isolated from common carp specimens during exposure to different physical treatments (temperatures of −18°C, +20°C, +40°C and +60°C) and chemical agents (5% and 10% acetic acid and 10% sodium chloride (NaCl)). Metacercariae lost viability by freezing at −18°C (2 h), heating at 60°C (20 min), incubation in 5% and 10% acetic acid (5 min) and 10% NaCl (2 h). These methods served as models to investigate the effectiveness of food preparation techniques (such as cold and hot smoking, freezing, salting and pickling) on the survival of metacercariae.
People and jaguars: new insights into the role of social factors in an old conflict
Authors: Caruso Flavia , Perovic Pablo G. , Tálamo Andrés , Trigo Carolina B. , Andrade-Díaz María S. , Marás Gustavo A. , Saravia Diego , Sillero-Zubiri Claudio , Altrichter Mariana 
Published: January 2020

AbstractThroughout its range in Latin America, the jaguar Panthera onca is threatened by habitat loss and fragmentation, and by conflict as a result of coexistence with people. This Near Threatened species is a top predator, and is often illegally hunted. Understanding people's attitudes and perceptions and the factors that could influence them is crucial for the conservation of this species. In this study we assess how knowledge, attitudes and perceptions among people in northern Argentina regarding jaguars vary depending on their level of education, age and occupation. We interviewed 810 people living in and around 10 protected areas in northern Argentina. Positive perceptions and attitudes towards the jaguar were associated with economic benefits that people may receive from the species’ presence, such as income from tourism. Unexpectedly, higher levels of formal education were not associated with more positive attitudes and perceptions. Negative attitudes and perceptions towards the species were determined by fear; people see jaguars as a threat to their lives. This study shows that the socio-economic factors that affect the level of tolerance towards jaguars are not related only to economic losses. Our findings provide information for the design, implementation and evaluation of jaguar conservation projects in Argentina.