bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-objective microservice deployment optimization via a knowledge-driven evolutionary algorithm
Authors: Ma Wubin , Wang Rui , Gu Yuanlin , Meng Qinggang , Huang Hongbin , Deng Su , Wu Yahui 
Published: August 2020

AbstractFor the deployment and startup of microservice instances in different resource centres, we propose an optimization problem model based on the evolutionary multi-objective theory. The objective functions of the model consider the computation and storage resource utilization rate, load balancing rate, and actual microservice usage rate in resource service centres. The constraints of the model are the completeness of service, total amount of storage resources, and total number of microservices. In this study, a knowledge-driven evolutionary algorithm (named MGR-NSGA-III) is proposed to solve the problem model and seek the optimal deployment and startup strategy of microservice instances in different resource centres. The proposed model and solution have been evaluated via real data experiments. The results show that our approach is better than the traditional microservice instance deployment and startup strategy. The average computation rate, storage idle rate, and actual microservice idle rate were 13.21%, 5.2%, and 16.67% lower than those in NSGA-III, respectively. After 50, 100, and 150 evolutionary generations in serval operations, the population members in NGR-NSGA-III dominated the population members in NSGA-III 6,270, 3,581, and 7,978 times in average, respectively, which means that NGR-NSGA-III can converge to the optimal solution much quicker than NSGA-III.
Change Detection and Trend Analysis of Future Temperature and Rainfall over West Africa
Authors: Ilori Oluwaseun W. , Ajayi Vincent O. 
Published: August 2020

AbstractThis paper examined future trends with change detection in temperature and rainfall over three agro-climatic zones of West Africa. Historical (1961–2000) and projection (2020–2099) data of ensemble-mean of six RCMs that dynamically downscaled five GCMs that participated in CMIP5 obtained from Co-Ordinated Regional Climate Downscaling Experiment (CORDEX) were used. Standard normal homogeneity, Buishand’s, Pettitt’s, and Mann–Kendall test were used for change point detection and trend analysis at 5% significant level. Inter-annual anomaly and projected change in the seasonal cycle relative to historical mean were investigated. The ensemble-mean evaluation performed for the historical period (1961–2000) using CRU dataset revealed that the change point occurred in rainfall and temperature series in the 1970s and 1980s, while a significant increasing trend is observed in temperature in all climatic zones. Change-point detection test projects rainfall series to be homogeneous as significant change point is expected to occur in temperature for all zones under RCP4.5 and RCP8.5 for near (2020–2059) and far-future (2060–2099). For the near-future, an increase in the mean temperature between 0.5–1.30 ℃ and 0.19–1.67 ℃ is projected to occur under RCP4.5 and RCP8.5 respectively. Projected relative change in seasonal cycle shows that winter months may witness increase in rainfall amounts under RCP4.5 but significantly dry under RCP8.5 in near and far-future as temperature is expected to become warmer in all months. Rainfall anomaly projects the Sahel to have a reduced amount of rainfall compared to other zones as temperature anomaly reveals a continuous increase in all the zones under the two RCPs. The results of this study show that climate change will intensify in West Africa in the future.
The impact of transcription-mediated replication stress on genome instability and human disease
Authors: Gnan Stefano , Liu Yaqun , Spagnuolo Manuela , Chen Chun-Long 
Published: August 2020

AbstractDNA replication is a vital process in all living organisms. At each cell division, > 30,000 replication origins are activated in a coordinated manner to ensure the duplication of > 6 billion base pairs of the human genome. During differentiation and development, this program must adapt to changes in chromatin organization and gene transcription: its deregulation can challenge genome stability, which is a leading cause of many diseases including cancers and neurological disorders. Over the past decade, great progress has been made to better understand the mechanisms of DNA replication regulation and how its deregulation challenges genome integrity and leads to human disease. Growing evidence shows that gene transcription has an essential role in shaping the landscape of genome replication, while it is also a major source of endogenous replication stress inducing genome instability. In this review, we discuss the current knowledge on the various mechanisms by which gene transcription can impact on DNA replication, leading to genome instability and human disease.
The Prohibition on Constitutional Review by the Judiciary in the Netherlands in Critical Perspective: The Case and Roadmap for Reform
Authors: van der Schyff Gerhard 
Published: September 2020

AbstractParadoxically, at roughly the same time in the Netherlands the amendment bill to introduce constitutional review by the judiciary of acts of parliament lapsed in 2018, the State Commission on the Parliamentary System recommended that such review be introduced. This Article analyzes Dutch exceptionalism on the topic of prohibiting constitutional review and comes to the conclusion that it cannot be justified. Focusing on the nature of constitutional change in the country, the recommendation is made that the quest for reform should start with the courts, and not with the constitutional legislature, as has been the case to date.
Is the Primacy of EU Law Based on the Equality of the Member States? A Comment on the CJEU’s Press Release Following the PSPP Judgment
Authors: Lindeboom Justin 
Published: September 2020

AbstractIn response to the BVerfG’s PSPP judgment, the CJEU issued an unprecedented press release in which it claimed that national courts must give full effect to EU law because this is the only way to ensure the equality of the Member States. While the press release does not contain the word “primacy,” the obligation to give full effect to EU law clearly implies primacy of EU law. This article provides a constructive and critical analysis of the press release’s “equality argument.” First, it demonstrates how the CJEU most likely borrowed it from a recent article by Federico Fabbrini, and how the argument is virtually identical to Kelsen’s defense of international law primacy. Second, it criticizes the equality argument for being inconsistent with the CJEU’s case law, and shows how it is either wrong or tautological. After suggesting three possible reasons why the press release nonetheless justifies primacy in this way, the article concludes by showing how the CJEU’s case law is better conceptualized from a Hamiltonian perspective in which full effect is a goal rather than a means.
The German Constitutional Court’s PSPP Judgment: Impediment and Impetus for the Democratization of Europe
Authors: Feichtner Isabel 
Published: September 2020

AbstractThe article explores the understandings of democracy underlying the judgment and its implications for the democratization of Europe. I read the judgement, critically, as impediment and, constructively, as impetus for the democratization of money and society. Firstly, I recount how the Federal Constitutional Court (FCC) through the construction of a “right to democracy” and the concepts of “ultra vires act” and “integration responsibility” asserted its jurisdiction over the limits of European integration. The court’s reasoning prompts me to understand the judgment not as a defense of democracy, but rather as an instance of upholding a “rule of law” that impedes the democratization of society. Secondly, I turn to the pronouncements on the demarcation of monetary from economic competences by the Court of Justice of the European Union (CJEU) and the FCC. I explain what I hold to be the weaknesses in the FCC’s critique of the CJEU from a doctrinal perspective. I then propose to read the PSPP judgment constructively as introducing a procedural requirement that may democratize monetary policy. Thirdly, I situate my reading of the judgment in the larger debate on the democratization of society and, more specifically, money.
Oblique-change matters: ‘bradyseismic’ institutional change in local government
Authors: Bolgherini Silvia , Lippi Andrea 
Published: September 2020

AbstractIn the last 30 years, Local Governments all over Europe experienced an intense season of institutional change of unprecedented width and intensity. This paper focuses on a neglected type of institutional change, a more indirect one – here labeled oblique-change – that however strongly influences the overall LG institutional change and local autonomy. Taking 2012 as the climax of the austerity period in Europe and Italy as a pilot case for future comparisons, this article shows that oblique-change matters to a considerable extent, and that it is much more frequent and highly impacting than expected. Moreover, it argues that bradyseismic adjustments provoked by oblique-change may turn out in an equally profound change of the local government's asset, as that induced by major reforms.
In-phase and out-of-phase behavior of the East Asian summer and winter monsoons recorded in the South Yellow Sea sediment over the past 9.5 ka
Authors: Wang Liyan , Li Guangxue , Wang Linmiao , Zhang Wenchao , Zhang Yang , Liu Yong , Wang Xiangdong , Wang Haoyin 
Published: September 2020

AbstractThe variability of the East Asian monsoon (EAM) during the Holocene exhibits significant regional response, and its evolution needs further discussion. A well-dated, high-resolution sea-surface temperature record based on long-chain unsaturated alkenones, grain-size data, and clay mineral assemblages from the South Yellow Sea sediment is presented to investigate the sedimentary provenance and reconstruct the EAM over the past 9.5 ka. The results show that the sediments are most likely supplied by the Huanghe. The evolution of the East Asian summer monsoon (EASM) can be divided into three periods: strong and relatively stable conditions during 9.5–7.0 ka, weakened conditions during 7.0–1.5 ka, and strengthened conditions during 1.5–0 ka. The East Asian winter monsoon (EAWM) has experienced five periods: weakened conditions during 9.5–6.7 ka, weak and relatively stable conditions during 6.7–5.6 ka, strong and relatively stable conditions during 5.6–2.6 ka, strengthened conditions during 2.6–1.5 ka, and weak and stable conditions during 1.5–0 ka. Moreover, in-phase correlation was found between the EAWM and EASM at the orbital time scale in response to orbital-driven solar insolation, but out-of-phase correlation at a centennial time scale is predominantly associated with solar activity.
It's All About Solidarity Stupid! How Solidarity Frames Structure the Party Political Sphere
Authors: Thijssen Peter , Verheyen Pieter 
Published: September 2020

AbstractInspired by Lipset and Rokkan, the field of political science has primarily focused on party oppositions as a derivative of historically anchored conflicts among social groups. Yet parties are not mere social mirrors; they are also active interpreters of social context. In a globalized era they deploy conflicting frames on how solidarity may be preserved, as recent work on populist welfare chauvinism shows. However, the role of party political agency in framing solidarity lacks an overarching framework. This article therefore proposes a Durkheimian model that takes the integrative pole of the conflict–integration dialectic seriously and distinguishes among group-based, compassionate, exchange-based and empathic frames. The authors test this solidarity framework in Flanders (Belgium) – a good case study due to its fragmented party system and increasing economic and cultural openness. The content analyses of party manifestos presented here suggest that a solidarity-based deductive approach to studying partisan competition is relevant because partisan differentiation along solidarity lines is growing; this evolution converges with similar inductive expert-based and issue-based findings.
FROM ONE VESSEL TO ANOTHER: REFLECTIONS ON THE MUSIC OF NAOMI PINNOCK
Authors: Fox Christopher 
Published: September 2020

AbstractThis article explores aspects of the work of the composer Naomi Pinnock, focusing on six works written between 2012 and 2019: String Quartet No. 2 (2012), The Writings of Jakob Br. (2013), Lines and spaces (2015), Music for Europe (2016), The field is woven (2018) and I am, I am (2019). Each work is analysed and the analyses contextualised within a discussion of the works by other artists that form a creative hinterland to Pinnock's music: respectively art from the Sammlung Prinzhorn, paintings by Paul Klee and Agnes Martin, and the poetry of Rachael Boast.
Successfully treating refugees’ post-traumatic stress symptoms in a Ugandan settlement with group cognitive behaviour therapy
Authors: Goninon Elsa J. , Kannis-Dymand Lee , Sonderegger Robi , Mugisha Doddy , Lovell Geoff P. 
Published: September 2020

AbstractBackground:High rates of post-traumatic stress disorder (PTSD) are documented within refugee populations. Although research supports effectiveness of trauma-focused cognitive behaviour therapy (TF-CBT) among Western populations, little research exists for its efficacy among refugees living in camps and settlements in developing nations.Aims:To investigate whether a culturally sensitive, group-based TF-CBT programme (EMPOWER) delivered in a Ugandan refugee settlement effectively reduced refugees’ post-traumatic stress symptoms (PTSS), and whether sociodemographic factors, trauma characteristics, or PTSS severity related to programme completion or treatment outcomes.Method and Results:Data linkages were conducted on information provided by 174 Congolese refugees living in a Ugandan settlement (mean age = 33.4 years, SD = 11.7; 49% male). Using a quasi-experimental design, participants who initially completed the intervention (n = 43) delivered across nine 90-minute sessions, reported significant reductions in self-reported PTSS with a large effect size. The delayed treatment group (n = 55) also reported significant treatment gains once they received the intervention. Participants who completed the programme reported significantly greater initial PTSS severity than those who dropped out, while no sociodemographic factors, trauma characteristics or PTSS were associated with better treatment outcomes.Discussion:A culturally sensitive, group-based TF-CBT programme delivered in a refugee settlement meaningfully reduces refugees’ PTSS severity and is equally effective for all participants, with the highest retention rates found among those in greatest need of treatment. Programmes such as this, with capacity to treat hundreds of people simultaneously, represent highly cost-effective, accessible, disseminable and effective treatment for PTSS among refugees living in humanitarian settings in developing nations.
Membership born in the Interstitial Spaces of the British Empire: The Indian Question in South Africa from 1860 to 1960
Authors: MARTIN MARINA 
Published: September 2020

AbstractThis article revisits the question of Indian South Africans as a means of looking at a small selection of events1 situated within the dynamics between India, Britain and South Africa from 1860 to 1960, which were particularly influential in moulding the status of membership born within these interstitial spaces of the British Empire. Adopting a wider rather than a nationalist perspective, this discussion contributes to the growing global history scholarship looking at the relationship between India, Britain and its dominions.
A New Frontier in Ionospheric Observations: GPS Total Electron Content Measurements From Ocean Buoys
Authors: Azeem Irfan , Crowley Geoff , Forsythe Victoriya V. , Reynolds Adam S. , Stromberg Erik M. , Wilson Gordon R. , Kohler Craig A. 
Published: September 2020

AbstractGround‐based Global Navigation Satellite System (GNSS) receivers have become a ubiquitous tool for monitoring the ionosphere. Total electron content (TEC) data from globally distributed networks of ground‐based GNSS receivers are increasingly being used to characterize the ionosphere and its variability. The deployment of these GNSS receivers is currently limited to landmasses. This means that 7/10 of Earth's surface, which is covered by the oceans, is left unexplored for persistent ionospheric measurements. In this paper, we describe a new low‐power dual‐frequency Global Positioning System (GPS) receiver, called Remote Ionospheric Observatory (RIO), which is capable of operating from locations in the air, space, and the oceans as well as on land. Two RIO receivers were deployed and operated from the Tropical Atmosphere Ocean buoys in the Pacific Ocean, and the results are described in this paper. This is the first time that GPS receivers have been operated in open waters for an extended period. Data collected between 1 September 2018 and 31 December 2019 are shown. The observed TEC exhibits a clear seasonal dependence characterized by equinoctial maxima in the data at both locations. Both RIO receivers, deployed near the magnetic equator, show an 18–35% increase in TEC during moderately disturbed geomagnetic periods. Comparisons with the International Reference Ionosphere model show good agreement. The new capability presented in this paper addresses a critical gap in our ability to monitor the ionosphere from the 70% of the Earth's surface that is covered by water.
Pellino1 promotes chronic inflammatory skin disease via keratinocyte hyperproliferation and induction of the T helper 17 response
Authors: Kim Suhyeon , Lee Si-Yeon , Bae Seoyoon , Lee Jin-Kwan , Hwang Kyungrim , Go Heounjeong , Lee Chang-Woo 
Published: September 2020

AbstractPsoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established psoriasis. In this study, we found that the Pellino1 (Peli1) ubiquitin E3 ligase is activated by innate pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), and is highly upregulated in human psoriatic skin lesions and murine psoriasis-like models. Increased Peli1 expression is strongly correlated with the immunopathogenesis of psoriasis by activating hyperproliferation of keratinocytes in the S and G2/M phases of the cell cycle and promoting chronic skin inflammation. Furthermore, Peli1-induced psoriasis-like lesions showed significant changes in the expression levels of several T helper 17 (Th17)-related cytokines, such as IL-17a, IL-21, IL-22, IL-23, and IL-24, indicating that overexpression of Peli1 resulted in the sequential engagement of the Th17 cell response. However, the overexpression of Peli1 in T cells was insufficient to trigger psoriasis, while T cells were indispensable for disease manifestation. In summary, our findings demonstrate that Peli1 is a critical cell cycle activator of innate immunity, which subsequently links Th17 cell immune responses to the psoriatic microenvironment.
PuMYB21/PuMYB54 coordinate to activate PuPLDβ1 transcription during peel browning of cold-stored “Nanguo” pears
Authors: Sun Hua-Jun , Luo Man-Li , Zhou Xin , Zhou Qian , Sun Yang-Yang , Ge Wan-Ying , Yao Miao-Miao , Ji Shu-Juan 
Published: September 2020

AbstractRefrigeration is commonly used to extend the storage life of “Nanguo” pears, but fruit in long-term refrigeration is prone to peel browning, which is related to membrane lipid degradation. To determine the mechanism of membrane lipid degradation, we identified two R2R3-MYB transcription factors (TFs), PuMYB21 and PuMYB54, from “Nanguo” pears, which were notably expressed in response to cold stress and during the peel-browning process. The results from yeast one-hybrid, electrophoretic mobility shift, and transient expression assays indicated that both PuMYB21 and PuMYB54 directly bind to the promoter of PuPLDβ1 (a key enzyme catalyzing the hydrolysis of membrane phospholipids) and activate its expression, which probably enhances the degradation of membrane phospholipids and eventually results in peel browning. Moreover, the overexpression of PuMYB21 and PuMYB54 can greatly activate the transcription of endogenous PuPLDβ1 in both “Nanguo” pear fruits and calli, and their silencing can inhibit its transcription. Furthermore, yeast two-hybrid, bimolecular fluorescence complementation, and pull-down assays verified that PuMYB21 interacts with PuMYB54 to enhance the expression of PuPLDβ1. In summary, we demonstrate that PuMYB21 and PuMYB54 may have roles in membrane lipid metabolism by directly binding to the downstream structural gene PuPLDβ1 during the low temperature-induced peel browning of “Nanguo” pears.
Impact of rescanning and normalization on convolutional neural network performance in multi-center, whole-slide classification of prostate cancer
Authors: Swiderska-Chadaj Zaneta , de Bel Thomas , Blanchet Lionel , Baidoshvili Alexi , Vossen Dirk , van der Laak Jeroen , Litjens Geert 
Published: September 2020

AbstractAlgorithms can improve the objectivity and efficiency of histopathologic slide analysis. In this paper, we investigated the impact of scanning systems (scanners) and cycle-GAN-based normalization on algorithm performance, by comparing different deep learning models to automatically detect prostate cancer in whole-slide images. Specifically, we compare U-Net, DenseNet and EfficientNet. Models were developed on a multi-center cohort with 582 WSIs and subsequently evaluated on two independent test sets including 85 and 50 WSIs, respectively, to show the robustness of the proposed method to differing staining protocols and scanner types. We also investigated the application of normalization as a pre-processing step by two techniques, the whole-slide image color standardizer (WSICS) algorithm, and a cycle-GAN based method. For the two independent datasets we obtained an AUC of 0.92 and 0.83 respectively. After rescanning the AUC improves to 0.91/0.88 and after style normalization to 0.98/0.97. In the future our algorithm could be used to automatically pre-screen prostate biopsies to alleviate the workload of pathologists.