bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetrical fatiguing of the gluteus maximus muscles in the elite short-track female skaters.
Authors: Konieczny Mariusz , Pakosz Paweł , Witkowski Mateusz 
Published: March 2020

Abstract
Background: According to research, fast skating on short distances causes asymmetry in the physiology of muscle work. As has been proven in many sporting disciplines, this asymmetry can increase the risk of injury. The aim of the study was to analyze the level of right and left fatigue asymmetry of gluteus maximus muscle in elite skaters on a short track and to compare this phenomenon to a control group. The muscles were chosen deliberately, due to their influence in maintaining the right position during training on ice. Methods: The experiment compared a group of eight members of the Polish Women’s National Team in short track with a group of eight non-training people. The subjects did the Biering-Sorensen test, in which sEMG (surface electromyography) signal frequency was measured in the gluteus maximus muscles during an isometric contraction. Fatigue slopes were analyzed with a one-way ANOVA with repeated measures.. In the skaters, the fatigue differed between the right and the left gluteus maximus muscles. All the skaters had higher fatigue in the right leg. This phenomenon was not observed in the non-training subjects, who on average had similar fatigue in both legs. Results: The results suggest that professional short-track training leads to considerable asymmetry in fatigability of gluteus maximus muscles, thereby increasing the risk of injury in training and competition. Conclusions: Training should thus be planned in a way that minimizes the risk of causing muscle fatigue asymmetry in skaters despite the typically asymmetrical muscle work during training on ice and competition, thus new trainign protocols should be developed or considered to decrease that asymmetry. Trial registration: The tests were previously approved by the Bioethical Commission of the Chamber of Physicians in Opole. (Resolution No. 235 of 13 December 2016).
Paleoenvironmental Traces of Carbon and Oxygen Isotopes in Carbonate Rocks: An Example From Dengying Formation in Xichuan Area, Henan Province
Authors: Zhang Lan , Xie Hong , Li Qingguang , Lu Zhenghao , Bai Yang , Wang Mengzhai 
Published: March 2020

Abstract
The carbon and oxygen isotope composition of carbonate rocks is an important index for accurate analysis of the paleo-sea environment, which depends on Mn/Sr, δ 18 O > -10‰, correlativity of δ 13 C and δ 18 O and “age effect” of δ 18 O. This study reports carbon and oxygen isotope data of carbonate rocks from the Dengying Formation in the Xichuan area. δ 13 C values range -1.58‰ to 3.76‰, with an average value of 1.55‰, and δ 18 O values are -14.91‰ to -1.88‰, with an average value of -6.95‰. The δ 18 O values of three samples are less than -10‰, so they are excluded and taken to be correlative with the cracking of the Rodinia supercontinent during the Neoproterozoic. The paleotemperature range 7.40°C to 35.05°C, with an average value of 21.09°C. Paleo-salinity range 8.38‰ to 19.30‰, with an average value of 13.89‰. Z values range 127.80 to 135.03 and thus all exceeded 120, with an average value of 131.25. These calculations indicate that the Xichuan area had deposited marine carbonate rocks, with the hot and dry tropical monsoon climate, and a transgressive process overall during the Dengying age.
Quantitative comparison of pre-treatment predictive and post-treatment measured dosimetry for selective internal radiation therapy using cone-beam CT for tumor and liver perfusion territory definition
Authors: Rangraz Esmaeel Jafargholi , Tang Xikai , Maleux Geert , Dekervel Jeroen , Cutsem Eric Van , Verslype Chris , Baete Kristof , Nuyts Johan , Deroose Christophe M. 
Published: March 2020

Abstract
Background: Selective internal radiation therapy (SIRT) is a promising treatment for unresectable hepatic malignancies. Predictive dose calculation based on a simulation using technetium-99m-labeled macro-aggregated albumin ( 99m Tc-MAA) before the treatment is considered as a potential tool for patient-specific treatment planning. Post-treatment dose measurement is mainly performed to confirm the planned absorbed dose to the tumor and non-tumor liver volumes. This study compared the predicted and measured absorbed dose distributions. Methods: Thirty-one patients (67 tumors) treated by SIRT with resin microspheres were analyzed. Predicted and delivered absorbed dose was calculated using 99m Tc-MAA-SPECT and 90 Y TOF-PET imaging. The voxel-level dose distribution was derived using the local deposition model. Liver perfusion territories and tumors have been delineated on contrast-enhanced CBCT images, which have been acquired during the 99m Tc-MAA work-up. Several dose-volume histogram (DVH) parameters together with the mean dose for liver perfusion territories, non-tumoral and tumoral compartments were evaluated. Results: A strong correlation between the predicted and measured mean dose for non-tumoral volume was observed (r=0.937). The ratio of measured and predicted mean dose to this volume has a first, second, and third quartile range of 0.83, 1.05, and 1.25. The difference between the measured and predicted mean dose did not exceed 11 Gy. The correlation between predicted and measured mean dose to the tumor was moderate (r=0.623) with a mean difference of -9.3 Gy. The ratio of measured and predicted tumor mean dose had a median of 1.01 with the first and third quartile ranges of 0.58 and 1.59, respectively. Our results suggest that 99m Tc-MAA-based dosimetry could predict under or over dosing of the non-tumoral liver parenchyma for almost all cases. For more than two-thirds of the tumors, a predictive absorbed dose correctly indicated either good tumor dose coverage or under-dosing of the tumor. Conclusion: Our results highlight the predictive value of 99m Tc-MAA-based dose estimation to predict non-tumor liver irradiation, which can be applied to prescribe an optimized activity aiming at avoiding liver toxicity. Predictive dosimetry is also moderately reliable to estimate the tumor absorbed dose.
Use of static and dynamic 18F-FDopa PET parameters for detecting patients with glioma recurrence or progression
Authors: Zaragori Timothée , Ginet Merwan , Marie Pierre-Yves , Roch Veronique , Grignon Rachel , Gauchotte Guillaume , Rech Fabien , Blonski Marie , Lamiral Zohra , Taillandier Luc , Imbert Laetitia , Verger Antoine 
Published: March 2020

Abstract
Background: Static 18 F-FDopa PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of the present study was to evaluate the performances of static and dynamic 18 F-FDopa PET parameters for detecting patients with glioma recurrence/progression as well as to assess further relationships with patient outcome. Fifty-one consecutive patients who underwent an 18 F-FDopa PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters including mean and maximum tumor-to-normal-brain (TBR), tumor-to-striatum (TSR) ratios, and metabolic tumor volume (MTV), as well as dynamic parameters with time-to-peak (TTP) values and curve slope, were tested for predicting: 1) glioma recurrence/progression at 6-months after the PET exam and 2) survival on longer follow-up. Results: All static parameters were significant predictors of a glioma recurrence/progression (accuracy≥94%) with all parameters also associated with mean progression-free survival (PFS) in the overall population (all p<0.001, 29.7 vs. 0.4 months for TBR max , TSR max and MTV). The curve slope was the sole dynamic PET predictor of glioma recurrence/progression (accuracy=76.5%) and was also associated with the mean PFS (p<0.001, 18.0 vs. 0.4 months). However, no additional information was provided relative to static parameters in multivariate analysis. Conclusion: Although patients with glioma recurrence/progression can be detected by both static and dynamic 18 F-FDopa PET parameters, most of this diagnostic information can be achieved by conventional static parameters.
A single-model quality assessment method for poor quality protein structure
Authors: Ouyang Jianquan , Huang Ningqiao , Jiang Yunqi 
Published: March 2020

Abstract
Quality assessment of protein tertiary structure prediction models, in which structures of the best quality are selected from decoys, is a major challenge in protein structure prediction, and is crucial to determine a model’s utility and potential applications. Estimating the quality of a single model predicts the model’s quality based on the single model itself. In general, the Pearson correlation value of the quality assessment method increases in tandem with an increase in the quality of the model pool. However, there is no consensus regarding the best method to select a few good models from the poor quality model pool. In this work, we introduce a novel single-model quality assessment method for poor quality models that uses simple linear combinations of six features. We perform weighted search and linear regression on a large dataset of models from the 12th Critical Assessment of Protein Structure Prediction (CASP12) and benchmark the results on CASP13 models. We demonstrate that our method achieves outstanding performance on poor quality models.
Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura
Authors: Qin Zhaoxia , Su Jingjing , He Xin-Wei , Ban Shiyu , Zhu Qian , Cui Yangyang , Zhang Jilei , Hu Yue , Liu Yi-Sheng , Zhao Rong , Qiao Yuan , Li Jianqi , Liu Jian-Ren , Du Xiaoxia 
Published: March 2020

Abstract
Background: Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information processing and sensorimotor integration. The altered functional connectivity (FC) of sub-regions of sensorimotor brain areas with other brain cortex associated with migraine needs further investigation. Methods: Forty-eight migraine without aura (MWoAs) during the interictal phase and 48 age- and sex-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. We utilized seed-based functional connectivity analysis to investigate whether patients exhibited abnormal functional connectivity between sub-regions of sensorimotor brain areas and cortex regions. Results : We found that MWoAs exhibited disrupted FC between the sensorimotor areas and the visual cortex, temporal cortex, posterior parietal lobule, prefrontal areas, precuneus, cingulate gyrus, sensorimotor areas proper and cerebellum areas compared with healthy controls. In addition, the clinical data of the patients, such as disease duration, pain intensity and HIT-6 score, were negatively correlated with these impaired FC s. Conclusion : In MWoAs, the FCs between the sensorimotor brain areas and other brain regions was reduced. These disrupted FCs might contribute to abnormalities in visual processing, multisensory integration, nociception processing, spatial attention and intention and dysfunction in cognitive evaluation and modulation of pain. Recurrent headache attacks might lead to the disrupted network between L M1 (primary motor cortex) and temporal regions and between L S1 (primary somatosensory cortex) and temporal regions. Pain sensitivity and patient quality of life are closely tied to the abnormal functional connectivity between sensorimotor regions and other brain regions.
Temporal patterns of inflammatory biomarkers measured in the cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage using multiplex Proximity Extension Assay technology.
Authors: Vlachogiannis Pavlos , Hillered Lars , Enblad Per , Ronne-Engström Elisabeth 
Published: March 2020

Abstract
Background Neuroinflammation has been extensively studied in the context of subarachnoid hemorrhage (SAH) in recent years. A common approach is correlation of levels of single or few inflammatory biomarkers with clinical parameters such as cerebral vasospasm and outcome. However, the complexity of the inflammatory response post SAH may require a more comprehensive overall approach by analyzing multiple biomarkers simultaneously. Methods Twenty-nine patients with SAH requiring insertion of external ventricular drainage were enrolled and ventricular cerebrospinal fluid was collected at days 1, 4 and 10 after hemorrhage. The levels of 92 inflammatory biomarkers were simultaneously measured in the samples using Proseek Multiplex Inflammation 1® assay (Olink Proteomics, Uppsala, Sweden) based on Proximity Extension Assay (PEA) technology. Thirty-eight proteins were excluded from further analysis due to lack of >10% of measurable values. Temporal patterns for each of the remaining 54 proteins were illustrated on graphs with medians and quartiles. Wilcoxon matched pairs test was used for comparison of the medians between time points. Results Four different patterns were visually observed with an early peak and gradually decreasing trend (9 proteins), middle peak (14 proteins), late peak after a gradually increasing trend (27 proteins) and no specific pattern (4 proteins). Several biomarkers showed statistically significant increasing trends (defined as day 1 < day 4 < day 10 values) and late peaks (day 4 < day 10), such as chemokines CXCL6 and CCL23, or significant early peaks (that is, day 1 > day 4) such as leukemia inhibitor factor (LIF) and macrophage inflammatory factor-1β (MIP-1β). No statistically significant decreasing trends (defined as day 1 > day 4 > day 10) were observed. Two proteins showed statistically significant middle peaks (chemokine CCL28 and Delta and Notch epidermal growth factor-related receptor-DNER). Conclusion The comprehensive data set provided in this study may act as an illustration of an inflammatory profile of the acute phase of SAH showing groups of biomarkers with similar temporal patterns of activation. Further studies can be designed based on these data in order to explore potential implications on early and late clinical events in the disease course.
Clinicopathologic and outcome characteristics of breast cancer with liver metastases (BCLM): a population study of the SEER database and a registry analysis of 1728 women
Authors: wang zhonghua , ji Lei , Cheng Lei , Zhu Xiuzhi , Gao Yu , Fan Lei 
Published: March 2020

Abstract
Background Breast cancer patients generally have a worse prognosis in presence of liver metastasis. The purpose of this study was to evaluate the risk factors and prognosis of breast cancer patients with liver metastases (BCLM). Methods Data on 311,573 breast cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database diagnosed 2010 to 2016 and 1728 BCLM patients from Fudan University Shanghai Cancer Center (FUSCC) were analyzed for further exploration. We extracted the clinicopathological characteristics for analysis by two independent authors. Logistic regression was used to identify factors associated with the risk of liver metastases. Survival analysis was completed using Cox proportional hazards regression model and Kaplan-Meier analysis. Results Young age, invasive ductal carcinoma, higher pathological grade, and subtype of triple-negative and human epidermal growth factor receptor 2 positive (HER2+), were associated with increased risk of the liver metastases. The median overall survival (OS) after BCLM diagnosis was 20.0 months in the SEER database and 27.3 months in the FUSCC dataset. We observed that hormone receptor-positive (HR+)/HER2+ patients had the longest median OS 38.0 for SEER vs. 34.0months for FUSCC), whereas triple-negative breast cancer had the poorest OS (9.0 vs. 15.6 months) in both SEER and FUSCC. According to the results from the FUSCC, the subtype of HR+/HER2+ (hazard ratio (HR)=2.62; 95% confidence interval (CI)= 1.88-3.66; P<0.001) and HR-/HER2+ (HR=3.43; 95% CI=2.28-5.15; P<0.001) were associated with a significantly increased death risk in comparison with subtype of HR+/HER2-, if the patients did not receive HER2-targeted therapy. For BCLM patients who had received HER2-targeted therapy, however, HR+/HER2+ was an indicator for decreased death risk in comparison of the subtype of HR+/HER2- (HR=0.74; 95% CI=0.58-0.95; P<0.001). Conclusions BCLM is associated with poor survival, depending on HR/HER2-defined subtypes. Patients with HR+/HER2+ subtype displayed the longest median survival than HR+/HER2- and triple-negative BCLM patients. HER2-targeted therapy should be recommended for HER2+ BCLM patients.
The Impact of Age and Gender on Outcomes of Coronary Artery Bypass Grafting
Authors: lemaire anthony , Soto Cassandra , Salgueiro Lauren , Ikegami Hirohisa , Russo Mark J. , Lee Leonard Y. 
Published: March 2020

Abstract
Objective : As the population ages, increasing number of older patients are undergoing adult cardiac surgery. The purpose of the study is to assess the impact of age on postoperative outcomes in patients that undergo coronary artery bypass grafting (CABG).Methods : Patients that are ≥70 years old who underwent CABG were selected from the Nationwide/National Inpatient Sample from 2010 to 2015 using ICD-9-CM diagnosis and procedure codes. The patients who were 70–79 years old were compared to patients aged 80–89 years old to determine if the age difference of the patients had an impact on surgical outcomes. In addition, the gender of the patients 80-89 years old were compared to determine the influence of patient gender on surgical outcomes. The rates of postoperative complications, mortality, hospital length of stay (LOS), and cost were compared using the Chi-square test, multivariable logistic regression analysis, and Wilcoxon rank sum test.Results : A total of 67,568 patients were identified who were ≥70 years old and underwent CABG. Compared to the Septuagenarians, the Octogenarians were more likely to develop cardiac complications (OR [odds ratio] =1.20, 95% CI [confidence interval] 1.12-1.23. They were also more likely to develop renal complications (OR 1.54 95% CI 1.48-1.61, P <0001), respiratory complications (OR 1.2, 95% CI 1.2-2.1, P <0001), and infectious complications (OR=1.41, 95% CI 1.34-1.48, P <0001). The Octogenarians were also more likely to bleed postoperatively (P <0.0001) and have a higher mortality (OR 1.41 95% CI 1.36-1.61, P <0001). Moreover, the older patients had a longer postoperative LOS (median 9 days IQR [interquartile range] 7-13 days compared to the Septuagenarians (median 8 days IQR 6-11 days). The Octogenarians had an associated increased hospital cost (median $39,152 IQR $30, 0003.84 - $53,272.84) compared to the Septuagenarians (median $35,996.16 IQR $27,735.94 - $48,134.38). Furthermore, the female Octogenarians had a higher mortality (OR 1.25 95% CI 1.07–1.46) compared to males in the same age group.Conclusions : Advanced age influences surgical outcomes after CABG. The patients who were ≥80 – 89 years old had worse postoperative outcomes with increased complications and higher mortality compared to the Septuagenarians. Additionally, the Octogenarians who were females had a higher mortality compared to their male counterparts. These findings should help determine treatment options for older patients who need adult cardiac surgery.
Two Different Troponin Isoforms for Detection of Early Myocardial Injury after Curative Resection of Oesophageal Cancer
Authors: Gu Wei , Tang Wei , Zhang Zuojing , Xu Meiying , Wu Jingxiang 
Published: March 2020

Abstract
Background: The risk of intraoperative hypothermia, which may cause myocardial ischaemia during the early postoperative period, is relatively high in middle-aged and elderly patients undergoing curative resection of oesophageal cancer. The objective of this study was to explore the value of two troponin (cTn) subtypes, troponin I (cTnI) and high-sensitivity troponin T (hs-cTnT), which can be used to judge early myocardial injury after curative resection of oesophageal cancer.Methods: Seventy patients undergoing elective curative resection of oesophageal cancer were randomly assigned to undergo aggressive body temperature management (nasopharyngeal temperature ≥36°C) or standard body temperature management (n = 35 in each arm). Venous blood samples were collected from the patients before the operation and at postoperative 6 h~12 h, 24 h and 48 h, and serum cTnI and hs-cTnT levels were measured. The primary outcomes included the following: (1) the incidence of myocardial injury and the relationship between hs-cTnT and cTn; and (2) the consistency and correlation of the two cTn subtypes.Results: The incidence of postoperative day 2 myocardial injury was 8.6% (3/35) among patients receiving aggressive body temperature management and 31.4% (11/35) among patients receiving standard body temperature management (P<0.05). Among 3 patients who experienced myocardial injury in the aggressive body temperature management group, 2 met the diagnostic criteria for cTnI and hs-cTnT and only 1 met the diagnostic criteria for hs-cTnT. Among the 11 patients who experienced myocardial injury in the standard body temperature management group, 7 met the diagnostic criteria for cTnI and hs-cTnT and only 3 met the diagnostic criteria for hs-cTnT; only 1 met the diagnostic criteria for cTnI. The bias of cTnI and hs-cTnT was -8.82±31.91 ng/L. The consistency limit was -71.37~53.73 ng/L. The proportion within the scope of the consistency of its corresponding boundary was 98.57%. The correlation coefficient of cTnI and hs-cTnT was 0.845 (P<0.05).Conclusions: In the evaluation of postoperative myocardial injury in patients undergoing curative resection of oesophageal cancer, cTnI and hs-cTnT exhibit high consistency and a good correlation. The combination of cTnI and hs-cTnT can improve the detection rate of myocardial injury, thus providing a better reference than a single measure alone for reducing the risk of perioperative myocardial injury in patients.Trial registration: ChiCTR-INR-17011621. Registered June 10, 2017
Magnitude and determinants of adherence to iron supplementation among Ethiopian pregnant women: A cross sectional study from a national survey
Authors: Biru Yemisrach Belete , G/Kiristos Awet Fitwi , Lemelem Getasew Assefa , Mezen Muluemebet Kassa 
Published: March 2020

Abstract
The authors have requested that this preprint be removed from Research Square.