bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using stimulus equivalence‐based instruction to teach young children their caregivers' contact information
Authors: LaFond Tiffany R. , Reeve Kenneth F. , Day‐Watkins Jessica , Reeve Sharon A. , Vladescu Jason C. , Jennings Adrienne M. 
Published: August 2020

AbstractStimulus equivalence‐based instruction (EBI) was used to teach young children of typical development three 4‐member equivalence classes containing contact information from three caregivers (e.g., mother, father, and grandmother). Each class comprised the caregiver's (a) photograph, (b) printed name, (c) printed phone number, and (d) printed name of employer. A pretest‐train‐posttest‐maintenance design with a nontreatment control group comparison was used. Pretests and posttests assessed the degree to which class‐consistent responding occurred across both visual–visual matching tasks and intraverbals. Intraverbal responding was also probed with a novel instructor. Overall, EBI participants scored significantly higher during the posttests than the control participants across both the derived relations and intraverbal tests. These differences maintained 2 weeks later. Thus, responding generalized to (a) a different topography (i.e., intraverbal), (b) auditory versions of the stimuli, and (c) in the presence of a novel instructor. How such procedures may benefit lost children are discussed.
Modeling and simulation‐based design of electroenzymatic batch processes catalyzed by unspecific peroxygenase from A. aegerita
Authors: Bormann Sebastian , Hertweck Dominik , Schneider Sabrina , Bloh Jonathan Z. , Ulber Roland , Spiess Antje C. , Holtmann Dirk 
Published: August 2020

AbstractUnspecific peroxygenases have attracted interest due to their ability to catalyze the oxygenation of various types of C–H bonds using only hydrogen peroxide as a cosubstrate. Due to the instability of these enzymes at even low hydrogen peroxide concentrations, careful fed‐batch addition of the cosubstrate or ideally in situ production is required. While various approaches for hydrogen peroxide addition have been qualitatively assessed, only limited kinetic data concerning enzyme inactivation and peroxide accumulation has been reported so far. To obtain quantitative insights into the kinetics of such a process, a detailed data set for a peroxygenase‐catalyzed benzylic hydroxylation coupled with electrochemical hydrogen peroxide production is presented. Based on this data set, we set out to model such an electroenzymatic process. For this, initial velocity data for the benzylic hydroxylation is collected and an extended Ping‐Pong‐Bi‐Bi type rate equation is established, which sufficiently describes the enzyme kinetic. Moreover, we propose an empirical inactivation term based on the collected data set. Finally, we show that the full model does not only describe the process with sufficient accuracy, but can also be used predictively to control hydrogen peroxide feeding rates To limit the concentration of this critical cosubstrate in the system.
Diffusion tensor imaging study of brain precentral gyrus and postcentral gyrus during normal brain aging process
Authors: Zhou Ling , Tian Na , Geng Zuo‐Jun , Wu Bing‐Kun , Dong Li‐Ying , Wang Mei‐Rong 
Published: August 2020

AbstractObjectiveTo study the changes of white matter tracts in precentral gyrus and postcentral gyrus during normal brain aging process by analyzing fractional anisotropy (FA) values obtained from diffusion tensor imaging (DTI) technology.MethodsMagnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were conducted on 120 healthy right‐handed subjects. The subjects were separated into four age groups, namely Young Male/Female (<45 years old) and Senior Male/Female (>45 years old). Each subject undertakes routine MRI and DTI scans. Left/right precentral and left/right postcentral gyrus are automatically detected on the image. The area for region of interest (ROI) is set to be 18 ± 2 mm2.ResultsFor each age group, the FA values of white matter in precentral gyrus and postcentral gyrus are statistically different (p < .05) in both left and right sides of the brain across different age groups and genders. Additionally, the FA values are statistically different (p < .05) between two young and senior age groups across different genders, brain regions, and hemispheres.ConclusionThe FA values of precentral gyrus and postcentral gyrus are statistically different across genders, age groups, and hemispheres. Additionally, the FA values of both precentral gyrus and postcentral gyrus decrease over time, which is a strong indication of aging.
Sustainable product disposal: Consumer redistributing behaviors versus hoarding and throwing away
Authors: Sarigöllü Emine , Hou Chenxuan , Ertz Myriam 
Published: August 2020

AbstractBusiness strategies involving sustainable product disposal have focused mostly on technical aspects but neglected to adequately incorporate the nature of consumers' behavior. The current study addresses this void. We study consumer product disposal behavior and subsequently offer insights to businesses on how to incorporate consumer input into their strategic decision making in the light of opportunities to mitigate environmental impacts. Consumers' redistributing of unwanted but still useful products to others by reselling, passing along, or donating, rather than hoarding or throwing away, contributes to product lifetime extension and waste management. We study factors influencing product redistribution and explore profile of consumers who engage in various disposal behaviors. Findings from two online surveys, on mobile phones and sunglasses, reveal that specific waste attitudes, that is, waste minimization and waste aversion, rather than general environmental concern, are key determinants of product redistribution choice. Product cost is positively related to reselling and giving behaviors. Furthermore, product quality and product self‐image congruency significantly reduce the odds of throwing away. The method of product redistribution is also influenced by consumers' demographic characteristics including age, education level, and income. This paper advances extant literature on product disposal from the perspective of the consumer and provides input into development of business strategies that incorporate consumers' sustainable disposal behaviors. We also offer input to policy makers on how to curb or delay waste and pollution.
Immune‐related signature predicts the prognosis and immunotherapy benefit in bladder cancer
Authors: Wang Yejinpeng , Chen Liang , Yu Mengxue , Fang Yayun , Qian Kaiyu , Wang Gang , Ju Lingao , Xiao Yu , Wang Xinghuan 
Published: August 2020

AbstractBackgroundThere is no good prognostic model that could predict the prognosis of bladder cancer (BCa) and the benefit of immunotherapy.MethodsThrough the least absolute shrinkage and selection operator (LASSO) algorithm, we constructed a 13‐mRNA immune signature from the TCGA cohort (n = 406). We validated its prognostic value and predictive value for the benefit of immunotherapy with four independent validation cohort (GSE13507 [n = 256], GSE31684 [n = 93], GSE32894 [n = 308], and IMvigor210 cohort [n = 298]).ResultsOur results indicating that high‐risk group with higher inhibitory immune cell infiltration (regulatory T cells [Tregs] and macrophage, etc), higher expression of immune checkpoints, and more T cell suppressive pathways (transforming growth factor β [TGF‐β], epithelial‐mesenchymal transition [EMT], etc) were activated. Besides, the immune signature showed a good predictive value for the benefit of immunotherapy in a cohort of urothelial carcinoma patients treated with PD‐L1.ConclusionsThe immune signature constructed is convenient to classify the immunotherapeutic susceptibility of patients with BCa, so as to achieve precision immunotherapy for BCa.
The configurational influence mechanism of film consumption experience on customer satisfaction
Authors: Tang Zhongjun , Yu Lianghao 
Published: August 2020

AbstractTo ensure the quality of consumers' experience and realize the maximization of economic benefits in the short term, customer satisfaction has become increasingly significant in the film industry. This study clarifies the configurational influence mechanism between consumer expectation, brand image, and five experiential values toward film consumer satisfaction. With this aim, text data were mined and a new configurational customer satisfaction index model was constructed that integrates experiential value theory based on the European Consumer Satisfaction Index model. Additionally, fuzzy‐set qualitative comparative analysis is employed to explore the influence mechanism of film consumer satisfaction from the perspective of configuration. The five configurations produced correspond to five equivalent paths, which can be further divided into four types to explain the influence mechanism of film consumer satisfaction. Regarding the antecedent conditions, the intrinsic value of a film, followed by the extrinsic value are the key factors affecting satisfaction. This study changes the passive survey questionnaire output form to active input of comment mining. Additionally, it abandons the traditional regression perspective for research; a new configurational perspective is used to explore the complexity of antecedent conditions and the equivalence of consequence of film consumer satisfaction.
The Anti‐Inflammatory Properties of Rhododendron molle Leaf Extract in LPS‐Induced RAW264.7
Authors: Zong Luye , Zhang Jin , Dai Liangfang , Liu Jian , Yang Yan , Xie Jiankun , Luo Xiangdong 
Published: August 2020

AbstractRhododendron molle G.Don is a well‐known traditional medicine which has been used to treat rheumatic inflammation. In this study, an inflammatory model of lipopolysaccharide (LPS)‐stimulated RAW264.7 cells was established to analyze the anti‐inflammatory effect and potential mechanism of the methanol extract of R. molle leaves (RLE). The production of NO and the expression of tumor necrosis factor by LPS were detected by Griess reaction and enzyme linked immunosorbent assay (ELISA). The mRNA expression of TNF‐α, IL‐1β, IL‐6, COX‐2 and iNOS was measured by qRT‐PCR assay. Griess and qRT‐PCR showed that the RLE could significantly concentration‐dependently inhibit NO production and the expression of many pro‐inflammatory cytokines and inflammatory‐related enzymes. Scanning electron microscope (SEM) analysis indicated that RLE could inhibit LPS‐stimulated RAW264.7 macrophages activation. The protein level of TNF‐α and IL‐1β were decreased over 50 % at 100 μg/ml of RLE, as detected by ELISA. These results indicated that RLE had strong anti‐inflammatory and immunomodulatory activity.
Long non coding RNAs involved in MAPK pathway mechanism mediates diabetic neuropathic pain
Authors: Ren Xinlu , Yang Runan , Li Lin , Xu Xiumei , Liang Shangdong 
Published: August 2020

AbstractDiabetes is the largest global epidemic of the 21st century, and the cost of diabetes and its complications comprise about 12% of global health expenditure. Diabetic neuropathy is the most common complication of diabetes, affecting up to 50% of patients over the course of their disease. Among them, 30%–50% develop neuropathic pain, which has typical symptoms that originate from the toes and progress to foot ulcers and seriously influence quality of life. The pathogenesis of diabetic neuropathic pain (DNP) is complicated and incompletely understood and there is no effective treatment except supportive treatment. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs exceeding 200 nucleotides in length, have been shown to play key roles in fundamental cellular processes, and are considered to be potential targets for treatment. Recent research indicates that lncRNA is involved in the pathogenesis of DNP. Certain overexpressed lncRNAs can enhance the purinergic receptor‐mediated neuropathic pain in peripheral ganglia and inflammatory cytokines are released due to receptors activated by adenosine triphosphate. In recent years, our laboratory also has been exploring the relationship and pathogenesis between lncRNAs and DNP. In this review, we focus on the recent progress in functional lncRNAs associated with DNP and investigate their roles related to respective receptors.
Angiographic performance of everolimus‐eluting stents for the treatment of coronary in‐stent restenosis in daily practice
Authors: Wiebe Jens , Rai Himanshu , Kuna Constantin , Cassese Salvatore , Kessler Thorsten , Rheude Tobias , Colleran Roisin , Schunkert Heribert , Koch Tobias , Kufner Sebastian , Joner Michael , Kastrati Adnan , Byrne Robert A. 
Published: August 2020

AbstractObjectivesThe present study aims to analyze the angiographic anti‐restenotic performance of durable polymer everolimus‐eluting stents (EES) for the treatment of in‐stent restenosis (ISR) in daily practice.BackgroundRandomized data is available supporting the use of drug‐coated balloons and drug‐eluting stents for the treatment of ISR; however, additional real‐world data including angiographic follow‐up is needed.MethodsPatients who underwent EES‐implantation for the treatment of drug‐eluting stent ISR and attended for a 6–8 months angiographic surveillance were analyzed. Off‐line assessment of the angiograms was conducted at a central quantitative coronary angiographic core laboratory.ResultsA total of 426 patients with ISR were treated with EES and had undergone angiographic follow‐up. The mean age was 66.8 ± 9.9 years and 27.5% suffered from diabetes. A total of 459 lesions were treated. The diameter stenosis decreased from 64.3 ± 19.1% (preprocedural) to 12.0 ± 6.4% (postprocedural). At 6–8 months angiographic follow‐up, the in‐segment diameter stenosis was 38.3 ± 21.7% and the in‐stent late luminal loss was 0.54 ± 0.74 mm in the treated area analysis. The rate of recurrent binary restenosis was 25.7%.ConclusionsIn the setting of ISR, the angiographic anti‐restenotic efficacy of stenting with EES is comparable to that observed in randomized clinical trials and less favorable than its performance in patients undergoing stenting for de novo disease.
Enhancing the of Performance of Lithium‐Sulfur Batteries through Electrochemical Impregnation of Sulfur in Hierarchical Mesoporous Carbon Nanoparticles
Authors: Kim Seong‐Jun , Ahn Minchul , Park Jungjin , Jeoun Yunseo , Yu Seung‐Ho , Min Dal‐Hee , Sung Yung‐Eun 
Published: August 2020

AbstractHierarchical mesoporous carbon was studied as a key material for enhancing sulfur utilization in Li−S batteries. Commonly, thermal sulfur infiltration into mesoporous carbon was a representative method for S−C composites; however, these had some problems such as pore blocking or nonuniform deposition of sulfur. Electrochemical sulfur impregnation without chemical or thermal infiltration reduced the preprocess time and enabled efficient polysulfide diffusion into the carbon pores. As the soluble polysulfides are smaller and more mobile than solid‐state sulfur, they could be physically or chemically adsorbed into the pores of the carbon additives. This approach enhanced the cycle stability and rate performance of the batteries. This study will provide an efficient and economic use of porous carbons in the Li−S battery field.
Fabrication and characterization of zein/bioactive glass deposited on pretreated magnesium via electrophoretic deposition
Authors: Ahmed Yusra , Nawaz Aneeqa , Singh Virk Ranjot , Wadood Abdul , Ur Rehman Muhammad Atiq 
Published: August 2020

AbstractIn this study, zein/45S5 bioactive glass (BG) coatings were deposited via electrophoretic deposition (EPD) on pretreated pure magnesium (Mg) substrates to control the rapid degradation of magnesium and to improve the bioactive properties of Mg implants. The EPD parameters were first optimized on stainless steel (SS), and then, the optimum EPD parameters were applied to obtain zein/BG composite coatings on Mg substrates. The kinetics of the EPD process was studied by plotting the graph between current density and deposition time at fixed applied voltage. The morphology and chemical composition (qualitatively) of the obtained coatings were studied by scanning electron microscopy (SEM) and Fourier‐transformed infrared spectroscopy (FTIR), respectively. SEM and FTIR results showed that both zein and BG were successfully deposited, and a homogeneous film of zein/BG was formed on the surface of the substrate. The contact angle measurements confirmed that the zein/BG coatings are suitable for the initial protein attachment.
Enhanced Macroanion Recognition of Superchaotropic Keggin Clusters Achieved by Synergy of Anion–π and Anion–Cation Interactions
Authors: Qi Bo , An Sai , Luo Jiancheng , Liu Tianbo , Song Yu‐Fei 
Published: August 2020

AbstractKeggin clusters are the most widely used polyoxometalate building blocks for the construction advanced materials, but effective methods for precisely recognizing the isostructural analogues of Keggins are still limited. In this study we employed the zwitterionic molecule 4,4′‐dipyridyl N,N′‐dioxide as a recognition receptor to specifically bind to the three Keggin analogues PW12O403−, PMo12O403−, and SiW12O404−, which separately co‐assembled into three different types of spherical charged colloids of different sizes. The recognition phenomena were confirmed by electrochemical methods and their crystallization behavior. Compared with solely anion–cation interaction‐driven systems, the synergism with the anion–π interactions between the superchaotropic Keggins and the electron‐deficient pyridine rings is believed to enhance the recognition. This observation is intriguing as the long‐range solution assembly of Keggins is mainly driven by short‐range anion–π interactions. Our results show that the little‐noticed hydration shell of Keggins is significantly influenced by the superchaotropic effect, leading to differentiated binding affinity to the receptors and more obvious recognition phenomena between tungsten/molybdenum Keggin analogues.
Dipolar Nanocars Based on a Porphyrin Backbone
Authors: Nishino Toshio , Martin Colin J. , Takeuchi Hiroki , Lim Florence , Yasuhara Kazuma , Gisbert Yohan , Abid Seifallah , Saffon‐Merceron Nathalie , Kammerer Claire , Rapenne Gwénaël 
Published: August 2020

AbstractInvited for the cover of this issue is Gwénaël Rapenne and co‐workers from CEMES‐CNRS at University Paul Sabatier, Toulouse, France and from NAIST, Nara, Japan. The image depicts an artistic representation of a nanocar race. Read the full text of the article at 10.1002/chem.202001999.
Inter‐ and Intramolecular Aryl–Aryl Interactions in Partially Fluorinated Ethylenedioxy‐bridged Bisarenes**
Authors: Weddeling Jan‐Henrik , Vishnevskiy Yury V. , Neumann Beate , Stammler Hans‐Georg , Mitzel Norbert W. 
Published: August 2020

AbstractSeveral ethylenedioxy‐bridged bisarenes with a variety of type and number of aryl groups were synthesized to study non‐covalent dispersion‐driven inter‐ and intramolecular aryl–aryl interactions in the solid state and gas phase. Intramolecular interactions are preferably found in the gas phase. DFT calculations with and without dispersion correction show larger interacting aromatic groups increase the stabilization energy of folded conformers and decrease the intermolecular centroid–centroid distance. Single‐molecule structures generally adopt folded conformations with short intramolecular aryl–aryl contacts. Gas electron diffraction experiments were performed exemplarily for 1‐(pentafluorophenoxy)‐2‐(phenoxy)ethane. A new procedure for structure refinement was developed to deal with the conformational complexity of such molecules. The results are an experimental confirmation of the existence of folded conformations of this molecule with short intramolecular aryl–aryl distances in the gas phase. Solid‐state structures are dominated by stretched structures without intramolecular aryl–aryl interactions but interactions with neighboring molecules.
Nickel‐Catalyzed Cross‐Coupling of Aryl Pivalates with Cyclobutanols Involving C—O and C—C Bond Cleavage†
Authors: Gan Yi , Zhang Ninghui , Huang Shaoxu , Liu Yuanhong 
Published: August 2020

Summary of main observation and conclusionAn efficient nickel‐catalyzed cross‐coupling of aryl pivalates with cyclobutanols is described. The use of Ni(cod)2/PCy3/base as the catalytic system enables the cleavage of inert C—O bond and C—C bond under mild conditions, thus providing a facile access to γ‐arylated ketones in generally good to excellent yields. This transformation is also characterized by wide substrate scope and functional group compatibility, for example, methoxy, N,N‐dimethylamino, keto, ester, fluoro and TMS groups are well‐tolerated during the reaction process.
Experimentally Established Benchmark Calculations of 31P NMR Quantities
Authors: Shenderovich Ilya G. 
Published: August 2020

AbstractThe accuracy of different density function theory functionals and the MP2 approximation in 31P NMR calculations has been evaluated for ten phosphorous containing molecules in which the phosphorous atoms are not involved in intermolecular interactions. The obtained absolute chemical shielding tensors are compared to experimental ones. The dependence of the numerical values on the size of basis sets has been inspected from the 6‐311G(2d,p) to the pcSseg‐3 basis sets. General recommendations on the most reliable functionals and the smallest possible size of a basis set have been reported. For example, the use of the M06 L functional should be avoided. For five polycrystalline samples, the conformation of molecules has been identified with a high precision. These structures have been used to determine the reference values of the absolute chemical shielding for the TPSSh, B3LYP, and ωB97XD functionals and different basis sets. As reported in the supporting information, these structures can be used to determine the reference value of the absolute chemical shielding for any approximation of interest.
Neural anatomy of echinoid early juveniles and comparison of nervous system organization in echinoderms
Authors: Formery Laurent , Orange François , Formery Antoine , Yaguchi Shunsuke , Lowe Christopher J. , Schubert Michael , Croce Jenifer C. 
Published: August 2020

AbstractThe echinoderms are a phylum of marine deuterostomes characterized by the pentaradial (five fold) symmetry of their adult bodies. Due to this unusual body plan, adult echinoderms have long been excluded from comparative analyses aimed at understanding the origin and evolution of deuterostome nervous systems. Here, we investigated the neural anatomy of early juveniles of representatives of three of the five echinoderm classes: the echinoid Paracentrotus lividus, the asteroid Patiria miniata, and the holothuroid Parastichopus parvimensis. Using whole mount immunohistochemistry and confocal microscopy, we found that the nervous system of echinoid early juveniles is composed of three main structures: a basiepidermal nerve plexus, five radial nerve cords connected by a circumoral nerve ring, and peripheral nerves innervating the appendages. Our whole mount preparations further allowed us to obtain thorough descriptions of these structures and of several innervation patterns, in particular at the level of the appendages. Detailed comparisons of the echinoid juvenile nervous system with those of asteroid and holothuroid juveniles moreover supported a general conservation of the main neural structures in all three species, including at the level of the appendages. Our results support the previously proposed hypotheses for the existence of two neural units in echinoderms: one consisting of the basiepidermal nerve plexus to process sensory stimuli locally and one composed of the radial nerve cords and the peripheral nerves constituting a centralized control system. This study provides the basis for more in‐depth comparisons of the echinoderm adult nervous system with those of other animals, in particular hemichordates and chordates, to address the long‐standing controversies about deuterostome nervous system evolution.