bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of national policy on hand hygiene promotion activities in hospitals in Korea
Authors: Choe Pyoeng Gyun , Lim Jihee , Kim Eun Jin , Kim Jeong Hee , Shin Myoung Jin , Kim Sung Ran , Choi Jun Yong , Choi Young Hwa , Lee Kyung Won , Koo Hyunsook , Lee Hyungmin , Song Kyoung-Ho , Kim Eu Suk , Kim Nam Joong , Oh Myoung-don , Kim Hong Bin 
Published: September 2020

Abstract
Background
After the Middle East respiratory syndrome coronavirus outbreak in Korea in 2015, the Government established a strategy for infection prevention to encourage infection control activities in hospitals. The new policy was announced in December 2015 and implemented in September 2016. The aim of this study is to evaluate how infection control activities improved within Korean hospitals after the change in government policy.

Methods
Three cross-sectional surveys using the WHO Hand Hygiene Self-Assessment Framework (HHSAF) were conducted in 2013, 2015, and 2017. Using a multivariable linear regression model, we analyzed the change in total HHSAF score according to survey year.

Results
A total of 32 hospitals participated in the survey in 2013, 52 in 2015, and 101 in 2017. The number of inpatient beds per infection control professionals decreased from 324 in 2013 to 303 in 2015 and 179 in 2017. Most hospitals were at intermediate or advanced levels of progress (90.6% in 2013, 86.6% in 2015, and 94.1% in 2017). In the multivariable linear regression model, total HHSAF score was significantly associated with hospital teaching status (β coefficient of major teaching hospital, 52.6; 95% confidence interval [CI], 8.9 to 96.4; P = 0.018), beds size (β coefficient of 100 beds increase, 5.1; 95% CI, 0.3 to 9.8; P = 0.038), and survey time (β coefficient of 2017 survey, 45.1; 95% CI, 19.3 to 70.9; P = 0.001).

Conclusions
After the new national policy was implemented, the number of infection control professionals increased, and hand hygiene promotion activities were strengthened across Korean hospitals.
Increasing use of linezolid in a tertiary NICU during a 10-year period: reasons and concerns for the future
Authors: Matrat Lucie , Plaisant Frank , Barreto Christine , Claris Olivier , Butin Marine 
Published: September 2020

Abstract
Background
Linezolid has been increasingly used in tertiary NICUs. The objectives of this study were to explore the indications of these linezolid prescriptions, to analyze a possible misuse and to provide solutions to avoid such misuse.

Methods
A monocentric retrospective cohort study included all neonates hospitalized in one tertiary NICU between January 1st, 2010 and December 31st, 2019 and who received at least one administration of linezolid. These data were confronted to epidemiological and antibiotic use data from the same NICU. Two independent pediatricians secondarily classified linezolid uses as adequate or not.

Results
During the study period, 66 infections in 57 patients led to linezolid use. Most patients were pre-term and 21 patients (37%) died. Infections were mainly related to methicillin-resistant coagulase negative staphylococci and were frequently either pneumoniae (35%) or isolated bacteremia (48%), including 25 persistent bacteremia (64% of the 39 bacteremia). Need for a better tissue distribution or first-line treatment failure were the main reasons to initiate linezolid. Linezolid was administered for a median duration of 7 [3;10] days. No side effects were reported. Twenty-two (33%) of the 66 linezolid prescriptions were retrospectively classified as inadequate.

Conclusions
A rapid increase in linezolid prescriptions has been observed in our tertiary NICU, from 2014 to 2019, with 33% inadequate uses. This worrisome trend should lead to search for therapeutic alternatives and to work on antibiotic stewardship to prevent the emergence of new antimicrobial bacterial resistance.
6-shogaol suppresses oxidative damage in L6 muscle cells
Authors: Hur Jinyoung , Lee Yeonmi , Lee Chang Jun , Park Ho-Young , Choi Sang Yoon 
Published: September 2020

AbstractGinger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the production of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.
Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma
Authors: Zhang Li-Bo , Pang Rong-Rong , Qiao Qing-Hua , Wang Zhi-Hua , Xia Xin-Yi , Wang Chang-Jun , Xu Xiao-Li 
Published: September 2020

Abstract
Background
Gastrointestinal symptoms are not rare among coronavirus disease 2019 (COVID-19) patients, but there have been no reports regarding convalescent plasma therapy for the recovery of gastrointestinal problems in COVID-19 patients.

Case presentation
We present two cases of patients with COVID-19-associated recurrent diarrhea and positive fecal occult blood who successfully recovered after a one-time convalescent plasma administration.

Conclusion
When COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment, alternative therapy with convalescent plasma administration may be considered.
Animal navigation: a noisy magnetic sense?
Authors: Johnsen Sönke , Lohmann Kenneth J. , Warrant Eric. J. 
Published: September 2020

ABSTRACT
Diverse organisms use Earth's magnetic field as a cue in orientation and navigation. Nevertheless, eliciting magnetic orientation responses reliably, either in laboratory or natural settings, is often difficult. Many species appear to preferentially exploit non-magnetic cues if they are available, suggesting that the magnetic sense often serves as a redundant or ‘backup’ source of information. This raises an interesting paradox: Earth's magnetic field appears to be more pervasive and reliable than almost any other navigational cue. Why then do animals not rely almost exclusively on the geomagnetic field, while ignoring or downplaying other cues? Here, we explore a possible explanation: that the magnetic sense of animals is ‘noisy’, in that the magnetic signal is small relative to thermal and receptor noise. Magnetic receptors are thus unable to instantaneously acquire magnetic information that is highly precise or accurate. We speculate that extensive time-averaging and/or other higher-order neural processing of magnetic information is required, rendering the magnetic sense inefficient relative to alternative cues that can be detected faster and with less effort. This interpretation is consistent with experimental results suggesting a long time course for magnetic compass and map responses in some animals. Despite possible limitations, magnetoreception may be maintained by natural selection because the geomagnetic field is sometimes the only source of directional and/or positional information available.
Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa
Authors: Paul Proma , Procter Simon R. , Dangor Ziyaad , Bassat Quique , Abubakar Amina , Santhanam Sridhar , Libster Romina , Gonçalves Bronner P. , Madhi Shabir A. , Bardají Azucena , Mwangome Eva , Mabrouk Adam , John Hima B. , Sánchez Yanotti Clara , Chandna Jaya , Sithole Pamela , Mucasse Humberto , Katana Patrick V. , Koukounari Artemis , Harden Lois M. , Aerts Celine , Ghoor Azra , Leahy Shannon , Mbatha Sibongile , Lowick Sarah , Lala Sanjay G. , Bramugy Justina , Newton Charles , Hossain A. K. M. Tanvir , Sadeq-ur Rahman Qazi , Lambach Philipp , Jit Mark , Lawn Joy E. 
Published: September 2020

Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of infant iGBS disease each year, and an estimated 147,000 stillbirths and young-infant deaths, with the highest burden occurring in Sub-Saharan Africa. The following priority data gaps were highlighted: (1) long-term outcome data after infant iGBS, including mild disability, to calculate quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs) and (2) economic burden for iGBS survivors and their families. Geographic data gaps were also noted with few studies from low- and middle- income countries (LMIC), where the GBS burden is estimated to be the highest. In this paper we present the protocol for a multi-country matched cohort study designed to estimate the risk of long-term neurodevelopmental impairment (NDI), socioemotional behaviors, and economic outcomes for children who survive invasive GBS disease in Argentina, India, Kenya, Mozambique, and South Africa. Children will be identified from health demographic surveillance systems, hospital records, and among participants of previous epidemiological studies. The children will be aged between 18 months to 17 years. A tablet-based custom-designed application will be used to capture data from direct assessment of the child and interviews with the main caregiver. In addition, a parallel sub-study will prospectively measure the acute costs of hospitalization due to neonatal sepsis or meningitis, irrespective of underlying etiology. In summary, these data are necessary to characterize the consequences of iGBS disease and enable the advancement of effective strategies for survivors to reach their developmental and economic potential. In particular, our study will inform the development of a full public health value proposition on maternal GBS immunization that is being coordinated by the World Health Organization.
COVID-19: unmasking the facial protection paradigms
Authors: Samaranayake Lakshman , Shun Li Dion Tik 
Published: September 2020

A number of facial protection measures to mitigate the spread of COVID-19 is available to clinicians. Here, we comprehensively explore the pros and cons of different types of face masks including N95 respirators, face shields, and powered, filtering-facepiece respirators (FFRs) currently used to reduce airborne infection transmission in the dental clinic. The controversial issue of the `fit test` prior to the use of N95 masks, and the related, current, UK and US recommendations are additionally discussed. The article concludes with a section on facial skin health, and practical measures for circumventing the adverse skin effects due to prolonged mask wearing. CPD/Clinical Relevance: Post-COVID-19, ‘new normal’ entails significant re-adaptations of infection control in dentistry, including facial protection measures that are required for mitigating airborne infection transmission in the dental operatory. A strategic understanding of the theory and practice of facial protective measures, and the underlying technology of the various face masks and respirators available for dentistry, will be valuable for safeguarding the health of patients as well as the whole dental team.
Impact of remission on worries experienced by patients receiving biologic therapy for inflammatory bowel disease
Authors: Edelbo Rikke , Hjerrild Malte , Bager Palle 
Published: September 2020

Background: Patients with inflammatory bowel disease (IBD) are more and more often treated with biological therapy, primarily to induce remission and secondarily to maintain remission in IBD. Studies have shown how the patients' health-related quality of life (HRQoL) improves during treatment. However, worry and concern have not improved as rapidly as other HRQoL parameters. Aim: This study aimed to explore the aspects of worry in a population of patients treated with biological therapy. Methods: Patients were asked to score HRQoL on two scales and subsequently asked to elaborate on their worry issues. Findings: The study revealed that worries were independent of disease activity. The main worry issues were lack of energy, emotional impact, sleep, pain, work and body image. Emotional impact and body image were more burdensome for women than men. When elaborating on emotional impact, it was revealed that worries about the future and the burden of IBD were common.
Analisis Faktor-Faktor Yang Berperan Terhadap Kolaborasi Antara Dokter Dan Perawat Di Rumah Sakit Permata Medika Semarang
Authors: Intania Irena , Sujianto Untung , Jati Sutopo Patria 
Published: September 2020

Poor collaboration can affect the quality of service to patients, thus affecting the recovery of patients. For the profession, collaboration can affect the relationship and the job satisfaction of both doctors and nurses. Poor collaboration between doctors and nurses in hospital management can can influence a decrease number of Bed Occupation Rate and an increase in length of stay so that it can have an impact on patient satisfaction.This study used a quantitative design and descriptive analytic with qualitative approach through observation, review of documents, in-depth interviews with informants who already selected and determined using cross sectional approached. The sample in this study were all general practitioners and all nurses who work in Permata Medika Hospital until December 2015, ie 15 doctors and 15 nurses.The results show that the control of power is still difficult due to a balanced relationship between the two professions and poor communication. The scope of practice between doctors and nurses has established good collaboration. The shared interests of the two professions do not pay attention and see the procedure of service. At the collaborative goals of doctors and nurses there is overlapping responsibility for reasons of rushed work without regard to the Standard Operating Procedure (SOP) and job description.The Recommendations for management are need to be carried out definite career path for nurses, increase the knowledge and enhance the collaboration both nurses and doctors, increase the collaboration between nurses and doctors, follow up the results of service audits need to be coordinated and controlled
Analisis Implementasi Keselamatan dan Kesehatan Kerja Instalasi Radiologi Rumah Sakit X Kota Semarang
Authors: Kurniawan Akbar , Deny Hanifa Maher , Kana Nico L 
Published: September 2020

Occupational health and safety is one of the efforts to improve hospital services, especially in terms of health and safety for human resources of hospital, patient, visitors, and the surrounding comunity. One the hazards sources associated with K3RS in the radiation hazard that is part of the physical hazard. The radiology installation of RS X uses ionizing radiation in its services process. The purpose in this researchis to analyze the implementation of safety and health of radiology installation. Design of observational research with qualitative approach. Population research all human resources radiology installation unit (two people). K3RS (one Person), informant triangulation medical services manager (one person). Data were collected by in depth interview and observation techniques. The results of the identification indicate the limitations of human resources training, facilities and infrastructure, budget realization and coordination. Implementation based on government regulations has been implemented, both from the number and standard of human resources education, as well as fascilities and infrastructure such as lead protection, calibration and completeness of personal protective equipment. Some things that have been set at the beginning of plannning can not be realized, such as budgets and coordination commitments. It is advisable to increase human resources training, prioritize budgets that have been included in the initial plan, complement of incomplete facilities and infrastucture, increase the realization of the established coordination commitments
Evaluasi Kebijakan Perencanaan Obat Instalasi Farmasi Dinas Kesehatan Kota Semarang
Authors: Halida Fauzia , Sudiro Sudiro , Sugiarto Johanes 
Published: September 2020

Based on the Management of Public Drug and Health Supply Profile, the availability rate of drugs in Pharmaceutical Unit Health Department Semarang 2013-2015 was 107%, 110%, and 109% .The availability rate of drugs in Pharmaceutical Unit Health Department Semarang for 3 years in a row exceeds 100% showed a weakness in drugs planning process. Objective of this study was to analyse the planning process of drugs. This was descriptive research with qualitative method. Research subject is the primary respondents who developed drug planning policy and triangulation respondents who implement the drugs planning policy. Research object was Pharmaceutical Unit Health Department Semarang and Puskesmas. Data collected by observation, documentation study and depth interview and analysed using content analysis. The result showed that drugs selection was according to FORNAS and DOEN stated by Ministry of Health. The compilation stage of drugs application using data according to LPLPO and LB-1. The calculation of drugs necessity used combination method between consumption method used by clinic and epidemiology method for program medicine. Based on the consumption method formula, the current leadtime in Pharmaceutical Unit Health Department Semarang was too high (6 months) which caused the supplies more than 100 %. The drugs necessity projection budget already sufficient because it was supported from several sources, such as APBD2, APBD1, APBN, DAK, JKN. The adjustment of drugs supply planning used VEN Analysis. It is suggested that Pharmaceutical Unit Health Department Semarang should shortened the current leadtime and increase the socialization of drugs guidelines therefore Puskesmas able to implement the epidemiology method
Lateral obstacle avoidance control based on driving behavior recognition of the preceding vehicles in adjacent lanes
Authors: He Youguo , Gong Xing , Yuan Chaochun , Shen Jie , Du Yingkui 
Published: September 2020

Abstract
This paper proposes a lateral lane change obstacle avoidance constraint control simulation algorithm based on the driving behavior recognition of the preceding vehicles in adjacent lanes. Firstly, the driving behavior of the preceding vehicles is recognized based on the Hidden Markov Model, this research uses longitudinal velocity, lateral displacement and lateral velocity as the optimal observation signals to recognize the driving behaviors including lane-keeping, left-lane-changing or right-lane-changing; Secondly, through the simulation of the dangerous cutting-in behavior of the preceding vehicles in adjacent lanes, this paper calculates the ideal front wheel steering angle according to the designed lateral acceleration in the process of obstacle avoidance, designs the vehicle lateral motion controller by combining the backstepping and Dynamic Surface Control, and the safety boundary of the lateral motion is constrained based on the Barrier Lyapunov Function; Finally, simulation model is built, and the simulation results show that the designed controller has good performance. This active safety technology effectively reduces the impact on the autonomous vehicle safety when the preceding vehicle suddenly cuts into the lane.
Time-restricted feeding alters isoflurane-induced memory deficits
Authors: Song Jia , Chu Shuaishuai , Fang Xin , Xu Fangxia , Zhang Peng , Zhao Xin , Ma Zhengliang , Xia Tianjiao , Gu Xiaoping 
Published: September 2020

Abstract
Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0–ZT24, ad libitum feeding), Day-Feeding group (ZT0–ZT12, misaligned feeding), and Night-Feeding group (ZT12–ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction.
NILAI-NILAI PENDIDIKAN KARAKTER DALAM NASKAH DRAMA OPERA KECOA KARYA N.RIANTIARNO
Authors: Putro Agung Prayitno , Waluyo Herman J , Wardhani Nugraheni Eko 
Published: September 2020

Abstract: The purpose of this study is to describe the values of character education for Drama course. It is a qualitative descriptive study. The data were obtained from the play entitled Opera Kecoa¸ written by N.Riantiarno. by looking at the settings, the characters, the plots and some relevant documents. The technique used to collect the data was by document analysis technique. As one form of literary work, Opera Kecoa drama script contains character education values. The values of character education in this drama script are shown through characterizations and events in each chapter. Based on the results of the analysis found ten character education values contained in the drama Opera Kecoa, these values include: social care, tolerance, hard work, discipline, peace,patriotism, friendly, independent, creative, and responsibility. By reason of the values of these characters, the Opera Kecoa drama script can be used as a medium of learning in the college literature. Abstrak: Penelitian ini bertujuan mendeskripsikan nilai-nilai pendidikan karakter yang terdapat pada sebuah naskah drama. Penelitian ini menggunakan metode deskriptif kualitatif dengan subjek penelitiannya adalah naskah drama Opera Kecoa karya N.Riantiarno. Sumber data diperoleh dari tempat dan peristiwa, informan, naskah drama, dan dokumen. Pengumpulan data menggunakan teknik analisis dokumen. Sebagai salah satu bentuk karya sastra, naskah drama Opera Kecoa memuat nilai-nilai pendidikan karakter. Nilai-nilai pendidikan karakter dalam naskah drama ini ditampilkan melalui penokohan dan alur peristiwa pada setiap babaknya. Berdasarkan hasil analisis maka ditemukan sepuluh nilai pendidikan karakter yang terdapat dalam naskah drama Opera Kecoa, nilai-nilai tersebut antara lain: peduli sosial, toleransi, kerja keras, disiplin, cinta damai, cinta tanah air, bersahabat, mandiri, kreatif, dan tanggung jawab. Dengan alasan adanya nilai-nilai karakter tersebut maka naskah drama Opera Kecoa dapat digunakan sebagai salah satu media pembelajaran sastra di perguruan tinggi.