bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of Cardiopulmonary and Metabolic Functions during Jogging with and without Breast Supports: a randomized controlled trial
Authors: Chaunchaiyakul Rungchai , Masodsai Kunanya 
Published: April 2020

Abstract
Background:To shed light on the physiologic reasons behind exercise intolerance in active females, we investigated the physiological changes of cardiopulmonary and metabolic functions during jogging with and without breast supports.Methods/Design:Thirteen healthy females participated in three randomized jogging trials of no bra (NB, served as control), and two breast supports of casual bra (CB), and jogging bra (JB). Immediate effects of bras on static and dynamic lung functions were identified by using the standard pulmonary function test. Metabolic changes and cardiovascular functions were continuously determined at rest, during jogging and recovery.Results:Results showed the only immediate effect of donning jogging bra on temporary reductions in resting respiratory flow rates (forced expiratory volume in 1 second and maximum voluntary ventilation) (P<0.05) compared with pre-bras values, while static lung function remained unchanged. Theabove immediate effects of breast support on respiratory flow reductions regained during exercise. All cardiorespiratory and metabolic variables were similar among conditions (P>0.05) of either at rest, during or after jogging. Only casual bra showed significant late recovery in tidal volume, oxygen consumption and energy expenditure compared with resting values.Conclusions: Any types of breast support exhibit no limitation on cardiorespiratory and metabolic functions during jogging. Jogging with breast support is recommended during exercise for health promotion and wellbeing in adolescent girls and women.Trial registration: The current study was retrospectively registered. Clinicaltrials.in.th TCTR20200311002. Registered 11 March 2020.
Lay knowledge of cervical cancer in Manhiça district, Mozambique: a qualitative study
Authors: Menendez Yara Alonso , Cambaco Olga , Mindú Carolina , Nhantumbo Hoticha , Uamusse Titos , Matsinhe Graça , Matsinhe Benigna , Manjate Rosa Marlene , Macete Eusebio , Bardají Azucena , Menendez Clara , Sevene Esperança , Munguambe Khatia 
Published: April 2020

Abstract
Background Mozambique has one of the highest cervical cancer incidence rates in the world. Health interventions are still being conceived from a non-communicable disease standpoint despite it being a sexual and reproductive health concern. The objective of this study was to assess the extent to which lay perceptions of cervical cancer align with biomedical knowledge from the standpoint of sexual and reproductive health.Methods 10 FGD were carried out with 10 target groups in Manhiça. The target groups were diverse and ranged from of adolescent girls to informal drug vendors. There were a total of 116 participants. The FGD were used to obtain verbal information and trigger debates around beliefs and attitudes about cervical cancer as well as to explore notions of transmission and aetiology of the disease. The discussions were recorded for later transcription and analysis, following a combination of content and thematic analysis.Results Participants were familiar with the biomedical term ‘cervical cancer’ but knowledge of its aetiology and transmission was limited. Cervical cancer was readily associated to sexual transmission and sexually transmitted infections, and conceived as a ‘wound that doesn’t heal’. The term ‘cancer’ caused confusion, as it was perceived to happen only in limbs, understood as hereditary, not transmissible and as an illness of the West.Conclusions Lay perceptions of cervical cancer do to a large extent align with biomedical ones, thus, there is common ground to frame future health interventions from a sexual and reproductive health standpoint.
Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis.
Authors: Schippert Cordula , Witte Yvonne , Bartels Janina , Garcia-Rocha Guillermo-José , Jentschke Matthias , Hillemanns Peter , Kundu Sudip 
Published: April 2020

Abstract
Background Endometriosis can be associated with considerable pain and sterility. After surgical excision of moderate or severe endometriosis the recurrence rates amount to 50%. The objective of this retrospective study was to evaluate the recurrence and pregnancy rates following surgical resection of endometriosis stage III/IV. Methods 456 patients who underwent stage III/IV endometriosis surgery between 2004 and 2014 were sent a questionnaire relating to postoperative medical treatment, pregnancies, relief of symptoms and recurrence. Data and responses of 206 patients (45.2%) were analyzed. The statistical analysis was performed with the statistical software ´R`. Statistical significance was given if the p-value was less than 0.05. The study was approved by the local Ethics Committee of Hannover Medical School. Results 66.5% (N=137) of patients were established with stage III, 33.5% (N=69) with stage IV. Average age was 37 years (17-59). 63.1% (N=130) of surgeries were performed by laparoscopy with an average duration of 81 minutes, 21.8% (N=45; 189 minutes) by laparotomy and 15% (N=31; 202 minutes) by conversion. Complete resection of endometriosis was achieved in 90.8% (N=187). After surgery, 48.5% (N=100) of the women did not receive hormonal treatment, main reason was the desire for children in 53%. Complete or partial relief in complaints was achieved in 93.2% (N=192). Rate of recurrence was 21.8% (N=45). The association between incomplete resection and recurrence was on the threshold of significance (p=0.1). After surgery, 65.8% (79/120) of patients who wished to have children got pregnant. There is a statistically significant association between postoperative pregnancy rate and age <35 (p<0.002) and laparoscopic surgical access (p<0.01). Conclusion We assess the high percentage of complete or partial reduction of symptoms of 93.2%, the high postoperative pregnancy rate of 65.8% and the low rate of recurrence of 21.8% compared to international literature to be very encouraging for women suffering from moderate and severe endometriosis. Though laparoscopy is considered as ´gold standard` of endometriosis surgery, laparotomy still may be indicated in cases of extended endometriosis especially to preserve reproductive function.
Time to first birth and its Predictors among reproductive-age women in Ethiopia: inverse Weibull gamma shared frailty model
Authors: Yimer Reta Dewau , Mekonnen Fantahun Ayenew , Seretew Wullo Sisay 
Published: April 2020

Abstract
Background: High maternal and child death with high fertility rate have been reported in Ethiopia. Extreme age at first birth is linked with both maternal and child morbidity and mortality. However, literatures showed there are limited studies on timing of first birth and its predictors in the area so far. Therefore, determining time to first birth and its predictors will help to design strategies to improve maternal and child survival. Methods: A survey-based study was conducted among reproductive-age women in Ethiopia using Ethiopian demographic health survey (EDHS), 2016 data. Stratified two-stage cluster sampling technique was used for sampling. The Kaplan-Meier (KM) method was used to estimate time to first birth. Inverse Weibull gamma shared frailty model applied to model the data at 95% confidence interval (CI), adjusted hazard ratio (AHR) and median hazard ratio (MHR) were reported as effect size. Proportional hazard assumption checked using Schoenfeld residual test. Information Criteria was applied to select parsimonious model. Stratified analysis performed for interaction terms and statistical significance declared at p value<0.05. Results: The overall median age at first birth found to be 20 years (IQR, 16-24years). The independent predictors of time to first birth were: marriage 15-17 years (AHR=2.33,95% CI:2.08-2.63),secondary education level (AHR=0.84,95% CI:0.78-0.96), higher education level (AHR=0.75, 95% CI:0.65-0.85), intercourse before 15 years in the married stratum (AHR=23.81, 95% CI:22.22-25.64), intercourse 15-17 years in married stratum (AHR=5.56, 95% CI:5.26-5.88),spousal age difference (AHR=1.11, 95% CI :1.05-1.16),and use of contraceptives (AHR=0.91, 95% CI [0.86-0.97]). The median increase in the hazard of early childbirth at a cluster with higher early childbirth is 16% (MHR=1.16, 95% CI [1.13-1.20]) than low risk clusters.Conclusion: In this study, first birth found to be at an early age. Early age at first marriage, at first sexual intercourse and their interaction terms, high spousal age difference, being Muslim were found to increase early motherhood. Conversely, living in most urban region, secondary and higher women education were identified to delay first birth. Investing on women education and protecting them from early marriage are required to optimize time to first birth. The contextual differences in time to first birth are a novel finding which requires more study and interventions.
Knowledge, Attitude, and Practice of Cervical Cancer Screening and Associated Factors Among Reproductive Aged Women in Ethiopia: A Meta-Analysis and Systematic Review
Authors: Alamneh Yoseph Merkeb , Alamneh Alehegn Aderaw , Shiferaw Abtie Abebaw 
Published: April 2020

Abstract
Background: Cervical cancer is the leading cause of cancer deaths, accounting for 9% of female cancer deaths. In addition, more than 85% of cervical cancer related deaths are found in low and middle-income countries. Women’s knowledge and attitude are barriers for the uptake of cervical cancer screening service in Ethiopia. Studies conducted on knowledge, attitude, and practice of cervical cancer screening and associated factors among reproductive age women are inconsistent. Therefore, this systematic review and meta-analysis aimed to estimate the national level of knowledge, attitude, and practice of cervical cancer screening and associated factors among women aged 15-49 years in Ethiopia.Methods: An international database such as PubMed, EMBASE, Scopus, Google Scholar, Science Direct Cochrane library, and Grey literature databases were searched an extensively. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 guideline were pursued for this review. The quality of each study was assessed using Newcastle- Ottawa quality assessment tool. Stata version 14 was used to analyze the data. We have used a random effects model to estimate the pooled prevalence and odds ratio with 95% CI. The possible heterogeneity between studies was assessed using I-squared (I2) test statistic. Egger’s test was used to assess the publication bias. Result: Eighteen studies with a total of 9, 897 women were included in this meta-analysis. The pooled national level of knowledge, attitude and practice towards cervical cancer screening among 15-49 years old aged women in Ethiopia was 40.37% (95% CI: 30.09,50.66), 58.87% (95% CI: 42.69,75.05) and 14.02% (95% CI: 9.67,18.37) respectively. Being uneducated (OR: 3.10, 95% CI: 2.09,4.62), Women who had good knowledge (OR: 5.87, 95% CI: 2.57,13.40), Women who had positive attitude (OR: 4.20, 95% CI: 2.86,6.16) and not being married (OR: 3.34, 95% CI: 1.09,10.22) were the major factors of cervical cancer screening practice. Conclusions and Recommendation: This review showed that the level of knowledge, attitude, and practice of cervical cancer screening among reproductive-age women in Ethiopia was relatively lower. Educational status, knowledge, attitude and marital status were statistically significant factors for cervical cancer screening practice. Hence, the health care provider needs to scale up health education and awareness creation about cervical cancer screening and early detection and prevention of cervical cancer.
Guidance is an intervention: experiences and reflections of message mediators and message recipients for ‘alcohol in pregnancy’ guidance.
Authors: Trickey Heather , Brown Rachel 
Published: April 2020

Abstract
Background Heavy alcohol use in pregnancy is associated with poorer outcomes for babies, while evidence of harm from drinking at low levels is limited. UK guidance has been progressively strengthened, so that current guidance, underpinned by a precautionary principle, is to abstain from drinking alcohol if pregnant or planning a pregnancy. The aim of this study was to explore recipients’ and mediators’ awareness, experiences and reflections on the 2016 alcohol in pregnancy guidance. Methods Four focus groups explored the perspectives of policy makers, midwives, third sector advocates and new mothers. Transcripts were analysed thematically. Results Participants inferred a variety of lay programme theories to make sense of the precautionary principle, some of which may run counter to the intention of guidance developers. Participants also varied in their understanding of the role of message mediators, understandings included eliciting disclosures, communicating complexity, providing reassurance and contributing to social surveillance. Coherence of the guidance was challenged by paucity of underpinning evidence base, incongruence with the realities of pregnancy planning and a wider cultural norm of social drinking. Conclusions Improvements in efficacy may be achieved through recognition of guidance as a form of intervention in a complex system, underpinned by a logic model and with intended outcomes fully specified. Practical steps could be taken to nuance and layer communication of the underpinning evidence base. Communication strategies should carefully consider implications of ‘scope creep’ into pregnancy planning. Guidance could do more to address the role of partners and family members in supporting women’s decisions.
CNFE-SE: A novel hybrid approach combining complex network-based feature engineering and stacked ensemble to predict the success of Intrauterine Insemination and ranking the features
Authors: Ranjbari Sima , Khatibi Toktam , Dizaj Ahmad Vosough Taghi , Sajadi Hesamoddin , Totonchi Mehdi , Ghaffari Firouzeh 
Published: April 2020

Abstract
Background: Intrauterine Insemination (IUI) outcome prediction is a challenging issue with which the assisted reproductive technology (ART) practitioners are dealing. Predicting the success or failure of IUI based on the couples' features can assist the physicians to make the appropriate decision for suggesting IUI to the couples or not and/or continuing the treatment or not for them. The large number of studies that have been focused on predicting the IVF and ICSI outcome by machine learning algorithms. But, to the best of our knowledge, a few studies have been focused on predicting the outcome of IUI. The main aim of this study is to develop an automatic classification and feature scoring method to predict intrauterine insemination (IUI) outcome and ranking of the most significant features, based on patients' cycle’s characteristics under IUI treatment.Methods: For this purpose, a novel hybrid approach combining complex network-based feature engineering and stacked ensemble (CNFE-SE) is proposed. Three complex networks are extracted considering the patients' data similarities. The feature engineering step is performed on the complex networks. The original feature set and/or the features engineered are fed to the proposed stacked ensemble to classify and predict IUI outcome for couples per IUI treatment cycle. Our study is a retrospective study of a 5-year couples' data undergoing IUI. Data is collected from Reproductive Biomedicine Research Center, Royan Institute for 8,360 couples who underwent 11,255 IUI cycles were included. Results: Experimental results show that the proposed method outperforms the compared methods with AUC of 0.84 ± 0.01, sensitivity of 0.79 ± 0.01, specificity of 0.91 ± 0.01, and accuracy of 0.85 ± 0.01 for the prediction of IUI outcome. Conclusions: The most important predictors for predicting IUI outcome are semen parameters (sperm motility and concentration) as well as female BMI.
Mitochondrial COI gene is valid to delimitate Tylenchidae (Nematoda: Tylenchomorpha) species
Authors: Bai Mengxin , Qing Xue , Qiao Kaikai , Ning Xulan , Xiao Shun , Cheng Xi , Liu Guokun 
Published: April 2020

Abstract
Tylenchidae is a widely distributed soil-inhabiting nematode family. Regardless their abundance, molecular phylogeny based on rRNA genes is problematic, and the delimitation of taxa in this group remains poorly documented and highly uncertain. Mitochondrial Cytochrome Oxidase I (COI) gene is an important barcoding gene that has been widely used species identifications and phylogenetic analyses. However, currently COI data are only available for one species in Tylenchidae. In present study, we newly obtained 27 COI sequences from 12 species and 26 sequences from rRNA genes. The results suggest that the COI gene is valid to delimitate Tylenchidae species but fails to resolve phylogenetic relationships.
Differences in Students’ Perceptions of the Community of Inquiry in a Blended Synchronous Delivery Mode
Authors: Lafortune Anne-Marie , Lakhal Sawsen 
Published: April 2020

As more post-secondary institutions are turning to non-face-to-face course delivery modes to cater to the emerging needs of the student population, we have yet to find out whether students attending both at a distance and face-to-face have access to equal learning opportunities. A research was conducted in the nursing program taught in the blended synchronous delivery mode at the Cégep de la Gaspésie et des Îles over the winter 2017 semester. Using the Community of Inquiry framework and questionnaire elaborated by Garrison et al. (2000) and later revised by Shea and Bidjerano (2010), face-to-face (n=20) and at-a-distance (n=25) students’ perceptions of the four Community of Inquiry presences (teaching, social, cognitive and learner) were measured and compared. Results of the overall presences comparison reveal that face-to-face participants perceived a stronger teaching presence than students attending from a satellite site, while the distinctive elements of each presence reveal significant difference between students’ perceptions of the teaching, cognitive and learner presences. Additionally, students’ comments provide rich qualitative data that explain the quantitative results obtained.
Observando a Dinâmica Territorial do Emprego e do Deslocamento para Trabalho na Região do Vale do Rio Pardo-RS
Authors: Lima da Silveira Rogério Leandro , Silveira Daniel Claudy da , Brandt Grazielle Betina , Zanchi Verenice , De Oliveira Vinicios Gonchoroski 
Published: April 2020

A análise da dinâmica territorial do emprego e dos deslocamentos pendulares para trabalho no espaço intrarregional auxilia na compreensão do desenvolvimento territorial de uma dada região. Nesse artigo, analisamos como se apresenta, nos últimos anos, a dinâmica do emprego e dos deslocamentos pendulares entre os municípios da região do Vale do Rio Pardo, localizada no centro do estado do Rio Grande do Sul. A região apresenta desiguais níveis de dinamismo econômico entre seus municípios e está verticalmente integrada ao mercado global de tabaco. Os dados secundários utilizados foram obtidos junto ao IBGE (2010) e ao CAGED (2010). A organização dos dados, com base no uso de gráficos, tabelas e mapas temáticos possibilitou a análise da dinâmica temporal e espacial do emprego e dos deslocamentos pendulares para trabalho no território regional, através da identificação dos distintos níveis de centralidade econômica e dos fluxos de deslocamento pendular para trabalho no território regional. Observa-se que tal dinamismo não é espacialmente homogêneo através da concentração do emprego na cidade média de Santa Cruz do Sul e da sua desigual distribuição espacial no território, promovendo fluxos pendulares para o trabalho com diferentes intensidades e conteúdos entre os municípios da região.
Heat pump drying of industrial wastewater sludge
Authors: Yuan Gang , Chu Khim Hoong 
Published: April 2020

Abstract
The popularity of heat drying of wastewater sludge has increased over the past several years because it can reduce sludge mass and volume, and hence disposal costs. However, drying sludge using conventional combustion-heated dryers is energy-intensive. Heat pump dryers can be efficient and offer significant energy savings by recycling the drying heat. This paper describes a heat pump dryer designed for continuous drying of industrial wastewater sludge. The dryer constructed was essentially a closed-loop air system. The air used for drying is dehumidified to recover the latent heat of vaporization, re-heated using the recovered heat, and recirculated in a closed environment. The closed-loop layout eliminates emissions of dust, malodorous gases, and volatile compounds, obviating the need for exhaust treatment otherwise required to meet environmental regulations. Data on the moisture extraction rate, specific moisture extraction rate, and specific energy consumption are presented and discussed.
Dangerous Liaisons: Tau Interaction with Muscarinic Receptors
Authors: Wysocka Adrianna , Palasz Ewelina , Steczkowska Marta , Niewiadomska Grazyna 
Published: April 2020

:
The molecular processes underlying neurodegenerative diseases (such as Alzheimer's Disease
- AD) remain poorly understood. There is also an imperative need for disease-modifying therapies
in AD since the present treatments, acetylcholinesterase inhibitors and NMDA antagonists, do not halt
its progression. AD and other dementias present unique pathological features such as that of microtubule
associated protein tau metabolic regulation. Tau has numerous binding partners, including signaling
molecules, cytoskeletal elements and lipids, which suggests that it is a multifunctional protein. AD
has also been associated with severe loss of cholinergic markers in the brain and such loss may be due
to the toxic interaction of tau with cholinergic muscarinic receptors. By using specific antagonists of
muscarinic receptors it was found in vitro that extracellular tau binds to M1 and M3 receptors and
which the increase of intracellular calcium found in neuronal cells upon tau-binding. However, so far,
the significance of tau signaling through muscarinic receptor in vivo in tauopathic models remains uncertain.
The data reviewed in the present paper highlight the significant effect of M1 receptor/tau interaction
in exacerbating tauopathy related pathological features and suggest that selective M1 agonists
may serve as a prototype for future therapeutic development toward modification of currently intractable
neurodegenerative diseases, such as tauopathies.
Synthesis of Novel 3-(4-tert-Butylphenyl)-5-Cylopropyl-4H-1,2,4-Triazole Derivatives with Antioxidative and Antimicrobial Activities
Authors: Yildirim Nuri 
Published: April 2020

Background:
In this work, new heterocyclic compounds containing 3-(4-tertbutylphenyl)-
5-cyclopropyl-4H-1,2,4-triazole ring were synthesized, starting from iminoester hydrochlorides
and 4-tert-butylbenzhyrazide.

Methods:
Ethyl N-[(4-tert-butylphenyl)carbonyl]cyclopropanecarbohydrazonoate was used to synthesize
4-amino-3-(4-tert-butylphenyl)-5-cyclopropyl-4H-1,2,4-triazole, 3-(4-tert-butylphenyl)-5-
cyclopropyl-4-(arylmethyleneamino)-4H-1,2,4-triazole, 3-(4-tert-butylphenyl)-5-cyclopropyl-4-
(arylmethylamino)-4H-1,2,4-triazole and their phthalonitrile derivatives sequentially.

Results:
Seventeen new 3-(4-tert-butylphenyl)-5-cyclopropyl-4H-1,2,4-triazole derivatives were
synthesized and their antioxidant and antimicrobial activities were determined.

Conclusion:
Imine and amine derivatives were better antioxidants than phthalonitrile derivatives.
Doubly fluorination compounds appeared to result in higher activity. The compounds tested with
five microorganisms showed better activity against B. subtilis with the antimicrobial activity of two
far exceeding that of ampicillin. Imine and amine derivatives were better antimicrobials than phthalonitrile
derivatives.