bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nickel‐ and Cerium‐Doped Zeolite Composite: An Affordable Cathode Material for Biohydrogen Production in Microbial Electrolysis Cells
Authors: Wang Jiaxin , Li Yanchun , Liu Miaomiao , Li Zhifang , Gao Xiaole , Yang Donghua 
Published: August 2020

AbstractMicrobial electrolysis cells (MECs) is one of the promising biohydrogen production technologies for which low‐cost cathode materials are required and developed to propel the rapid development of MECs. Herein, the preparation of a low‐cost Ce0.1−Ni−Y composite is reported by using Y zeolite as carrier loaded with nickel (Ni) and cerium (Ce) as active components and its prominent electrochemical performance. The XPS analysis reveals that strong electronic interaction between Ni and Ce makes a great contribution to the electrochemical performance enhancement. The Ce0.1−Ni−Y with a peak current density of 39.8 A⋅m−2 in LSV, Tafel slope of 40.81 mV⋅dec−1, ECSA of 34.3 and hydrogen yield of 0.312±0.013 m3⋅m−3 d−1 are significantly superior to that of its parent Ni−Y counterpart and rival the performance of commercially Pt/C, which renders it a very promising hydrogen evolution catalyst for MECs.
The rax homeobox gene is mutated in the eyeless axolotl, Ambystoma mexicanum
Authors: Davis Erik S. , Voss Gareth , Miesfeld Joel B. , Zarate‐Sanchez Juan , Voss S. Randal , Glaser Tom 
Published: August 2020

AbstractBackgroundVertebrate eye formation requires coordinated inductive interactions between different embryonic tissue layers, first described in amphibians. A network of transcription factors and signaling molecules controls these steps, with mutations causing severe ocular, neuronal, and craniofacial defects. In eyeless mutant axolotls, eye morphogenesis arrests at the optic vesicle stage, before lens induction, and development of ventral forebrain structures is disrupted.ResultsWe identified a 5‐bp deletion in the rax (retina and anterior neural fold homeobox) gene, which was tightly linked to the recessive eyeless (e) axolotl locus in an F2 cross. This frameshift mutation, in exon 2, truncates RAX protein within the homeodomain (P154fs35X). Quantitative RNA analysis shows that mutant and wild‐type rax transcripts are equally abundant in E/e embryos. Translation appears to initiate from dual start codons, via leaky ribosome scanning, a conserved feature among gnathostome RAX proteins. Previous data show rax is expressed in the optic vesicle and diencephalon, deeply conserved among metazoans, and required for eye formation in other species.ConclusionThe eyeless axolotl mutation is a null allele in the rax homeobox gene, with primary defects in neural ectoderm, including the retinal and hypothalamic primordia.
Latent trajectories of eating disorder treatment response among female patients in residential care
Authors: Espel‐Huynh Hallie M. , Zhang Fengqing , Boswell James F. , Thomas John Graham , Thompson‐Brenner Heather , Juarascio Adrienne S. , Lowe Michael R. 
Published: August 2020

AbstractObjectiveEating disorder (ED) treatment outcomes are highly variable from beginning to end of treatment; however, little is known about differential trajectories during the course of treatment. This study sought to characterize heterogeneous patterns of ED treatment response during residential care.MethodParticipants were adolescent girls and adult women (N = 360) receiving residential ED treatment for anorexia nervosa, bulimia nervosa, binge‐eating disorder, other specified feeding or eating disorder, unspecified feeding or eating disorder, or avoidant/restrictive food intake disorder. Self‐report symptom assessments were completed at admission, discharge, and approximately weekly throughout the residential stay to assess curvilinear patterns of change. Latent growth mixture modeling was applied to identify subgroups of patients with similar treatment response trajectories.ResultsThree latent groups emerged, including gradual response (58.3%; steady improvements from admission to discharge), rapid response (23.9%; steep early improvements that were maintained through discharge), and low‐symptom static response (17.8%; nearly nonclinical self‐reported symptoms at admission that remained static through discharge). Groups differed on important clinical characteristics, such as body mass index, endorsement of compensatory behaviors, severity of global ED psychopathology at admission, and degree of symptom improvement by end of treatment.DiscussionPatients follow heterogeneous response patterns in residential ED treatment, and these patterns are associated with differential treatment outcome. Future work should explore whether these trajectories are associated with differential outcomes at follow‐up and whether tailoring clinical intervention to a patient's trajectory type can improve treatment response.
Inexpensive spot sampling provides unexpectedly effective indicators of watershed nitrogen status
Authors: Weller Donald E. , Jordan Thomas E. 
Published: August 2020

AbstractStream water quality data are essential for understanding watershed processes and managing water pollution, but the effort and expense of stream monitoring limit how many watersheds can be studied. For 59 small watersheds in the Chesapeake Bay drainage, we compared water quality measurements from inexpensive spot sampling to data from costly automated monitoring that used 1–3 yr of continuous flow measurement and weekly, temporally composited water sampling. Mean nitrogen (N) levels ranged from 0.01 to 16 mg N/L among streams. There were important temporal variations in N concentrations at each site, but the differences among sites were much greater. Spot samples were very effective at accurately and precisely placing average stream N levels within the N gradient among streams draining N‐enriched watersheds. Among watersheds, nitrate (NO3) and total N concentrations from spot samples were very strongly correlated with means from weekly composite sampling (R2 > 97%). We confirmed this result for independent data for 85 larger watersheds in the Chesapeake Bay Non‐tidal Network. NO3 concentration from a single March spot sample was highly correlated (R2 > 92%) with flow‐weighted average total N concentration synthesized from five years of monitoring. Spot sampling effectively quantifies average N status across N‐enriched watersheds because most N moves as dissolved NO3 in subsurface flow and that flux is much less variable than the episodic surface transport of particulate materials. For questions answered by quantifying average N levels, spot sampling can assess more watersheds at much lower cost than automated sampling, so it should be more widely used to support cost‐effective N research and management. For materials that are mainly bound to particulates, such as phosphorus, spot sampling is much less effective.
Treatment longevity and changes in surface fuel loads after pinyon–juniper mastication
Authors: Wozniak Samuel S. , Strand Eva K. , Johnson Timothy R. , Hulet April , Roundy Bruce A. , Young Kert 
Published: August 2020

AbstractIn the Intermountain West, land managers masticate pinyon pine (Pinus spp.) and juniper (Juniperus spp.) trees that have encroached sagebrush steppe communities to reduce canopy fuels, alter potential fire behavior, and promote growth of understory grasses, forbs, and shrubs. At three study sites in Utah, 45 sampling plots spanning a range of tree cover from 5% to 50% were masticated. We measured surface fuel load components three times over a 10‐yr period. We also measured tree cover, density, and height as indicators of treatment longevity. Changes in these variables were analyzed across the range of pre‐treatment tree cover using linear mixed effects modeling. We detected decreases in 1‐h down woody debris by 5–6 yr post‐treatment, and from 5–6 to 10 yr post‐treatment, but did not detect changes in 10‐h or 100 + 1000‐h down woody debris. By 10 yr post‐treatment, there was very little duff and tree litter left for all pre‐treatment tree cover values. Herbaceous fuels (all standing live and dead biomass) increased through 10 yr post‐treatment. At 10 yr post‐treatment, pinyon–juniper cover ranged 0–2.6%, and the majority of trees were <1 m in height. Given that 1‐h fuels were the only class of down woody debris that decreased, it may be beneficial to masticate woody fuels to the finest size possible. Decreases in 1‐h down woody debris and duff + litter fuels over time may have important implications for fire behavior and effects, but increases in herbaceous and shrub fuel loads should also be taken into account. At 10 yr post‐treatment, understory grasses and shrubs were not being outcompeted by trees, and average pinyon–juniper canopy cover was <1%. Therefore, tree regeneration was not sufficient to support a crown fire. In areas where sage‐grouse are a management concern, we recommend monitoring tree regeneration at mastication treatments at 10–15 yr post‐treatment.
Neighborhood context mediates probability of host tree mortality in a severe bark beetle outbreak
Authors: Buonanduci Michele S. , Morris Jenna E. , Agne Michelle C. , Harvey Brian J. 
Published: August 2020

AbstractUnderstanding drivers of disturbances across scales is critical as environmental constraints change in a warming climate. Outbreaks of native bark beetles (Curculionidae: Scolytinae) are key natural disturbances that shape the structure and function of conifer forests across the northern hemisphere. While drivers of bark beetle outbreaks have been studied extensively at spatial scales ranging from stands to continents, within‐stand processes governing individual tree mortality in an outbreak are less well understood. Here, we use a spatially explicit long‐term monitoring dataset of a lodgepole pine (Pinus contortavar.latifolia) forest (>9000 individually mapped trees in three 2‐ha plots) impacted by a severe mountain pine beetle (Dendroctonus ponderosae) outbreak to explore interactions among fine scale drivers of beetle‐caused tree mortality. Using a Bayesian spatial modeling approach, we evaluated how tree scale and tree neighborhood scale characteristics interact with tree size to mediate host tree susceptibility to mountain pine beetle outbreak in the Southern Rocky Mountains (USA). We found evidence that both tree growth rate preceding the outbreak and neighborhood structure (within a 10 meter radius of the host tree) mediate the effect of tree size, and that the direction and magnitude of these mediating effects vary with tree size. Tree scale mortality probability increased with pre‐outbreak growth rate for small to medium sized host trees (~10–25 cm diameter), but that same effect was not detected for large trees. Conversely, tree scale mortality probability increased with greater neighborhood density, with the most pronounced effects for medium to large sized host trees (~15–30 cm diameter). Within‐stand topographic variability was not an important predictor of mortality probability; among stands, however, the stand in the driest topographic position experienced the greatest overall mortality. By explicitly considering how within‐stand heterogeneity mediates individual tree scale susceptibility to bark beetle outbreak, our findings bridge an important gap in understanding multi‐scale drivers of disturbance dynamics.
Bacterial Cellulose Composite Solid Polymer Electrolyte With High Tensile Strength and Lithium Dendrite Inhibition for Long Life Battery
Authors: Li Yuhan , Sun Zongjie , Liu Dongyu , Lu Shiyao , Li Fei , Gao Guoxin , Zhu Min , Li Mingtao , Zhang Yanfeng , Bu Huaitian , Jia Zhiyu , Ding Shujiang 
Published: August 2020

The development of metallic lithium anode is restrained by lithium dendrite growth during cycling. The solid polymer electrolyte with high mechanical strength and lithium ion conductivity could be applied to inhibit lithium dendrite growth. To prepare the high‐performance solid polymer electrolyte, the environment‐friendly and cheap bacterial cellulose (BC) is used as filler incorporating with PEO‐based electrolyte owing to good mechanical properties and Li salts compatibility. PEO/LiTFSI/BC composite solid polymer electrolytes (CSPE) are prepared easily by aqueous mixing in water. The lithium ion transference number of PEO/LiTFSI/BC CSPE is 0.57, which is higher than PEO/LiTFSI solid polymer electrolyte (SPE) (0.409). The PEO/LiTFSI/BC CSPE exhibits larger tensile strength (4.43 MPa) than PEO/LiTFSI SPE (1.34 MPa). The electrochemical window of composite electrolyte is widened 1.43 V by adding BC. Density functional theory calculations indicate that flex of PEO chains around Li atoms is suppressed, suggesting the enhanced lithium ion conductivity. Frontier molecular orbitals results suggest that an unfavorable intermolecular charge transfer lead to achieve higher potential for BC composite electrolyte. All solid‐state Li metal battery with PEO/LiTFSI/BC CSPE delivers longer cycle life for 600 cycles than PEO/LiTFSI SPE battery (50 cycles). Li symmetrical battery using PEO/LiTFSI/BC CSPE could be stable for 1160 h.
Themes of Contemporary Inland Fisheries Goals
Authors: Aldridge Caleb A , Miranda Leandro E , Colvin Michael E 
Published: August 2020

Abstract
Goals are important for the effective execution of public trust responsibilities by state inland fisheries bureaus, but formulating meaningful goals is not simple. Often bureaus look to their past and to their sister bureaus in neighboring states when crafting goals for their own freshwater resources. Herein, we review the goal themes of fisheries bureaus using publicly available documents and guided by previous literature. We test whether goals exhibit geographic patterns, presuming that differences and similarities in climate, natural resources, and people determine, to various degrees, the goal themes across the United States. We identified nine distinct goal themes, but found that they do not form clear geographic patterns, which contrasts with a similar analysis conducted in the 1970s. Since the 1970s, fisheries bureau goals have expanded and regionalism in goals has vanished. We suggest that changes in perspectives and communication technology, as well as provisions within nationwide funding mechanisms, have led to goals becoming more homogenous across the USA and more diverse within each bureau.
Effect of potato flour on quality and staling properties of wheat–potato flour bread
Authors: Ju Qian , Li Yaoxi , Sun Huaxing , Chen Jincheng , Yuan Yanqiu , Hu Yayun , Fujita Kaori , Luan Guangzhong 
Published: August 2020

AbstractTo elucidate the impact of potato flour (PF) on quality changes and staling characteristics of the composite bread from wheat–potato flour (WPF), the physicochemical (specific volume, colority, sensory value, texture, and viscosity) properties, and staling (X‐ray diffraction and water migration) properties of bread were investigated. The quality of composite bread was comparable to wheat bread when addition level of PF at 20%, but decreased when the addition level increased to 30% or more, and became unacceptable at 50%. A chewy mouthfeel and an elastic and none‐crumbly texture were observed on composite bread, which had higher hardness than wheat bread, and could keep on both longer linear distance and higher linear force during compression test. It indicated that such new parameters other than hardness should be introduced to coordinate with the texture quality of composite bread. During storage, the higher addition level of PF significantly decreased crystallinity of composite bread and slowed water migration rate from the crumb to crust, suggesting that PF had antistaling effect on composite bread, which was further emphasized by the fact that the setback value of the WPF decreased with the increase of PF addition.
Dietary effects on breast cancer molecular subtypes, a 1:2 paired case–control study
Authors: Yuan Guohai , Zhang Jingjing , Ren Yi , Ding Wei , Du Yan , Zhang Lu , Shao Jihong 
Published: August 2020

AbstractTo explore the associations between dietary factors and breast cancer (BC) molecular subtypes. The retrospective cases were confirmed by pathological diagnosis with breast cancer were gathered in two major hospitals in Xuzhou city, China, from 2015 to 2016. These cases were classified by the meeting standard of 13th St Gallen: luminal A, luminal B, Her‐2 overexpression, and triple‐negative breast cancer (TNBC) subtypes. A 1:2 paired retrospective case–control study with 210 cases and 420 controls was conducted to evaluate individual dietary intake, by food frequency questionnaire (FFQ) and estimate odds ratios (ORs), by the Cox regression model. For overall breast cancer patients, the more frequency of red meat (OR = 1.002, 95% CI = 1.001–1.004) and salted food (OR = 1.003, 95% CI = 1.001–1.005) were statistically significantly associated with a greater risk of breast cancer. Beans (OR = 0.997, 95% CI = 0.995–0.999), white meat (OR = 0.993, 95% CI = 0.989–0.997), aquatic products (OR = 0.990, 95% CI = 0.984–0.996), vegetables (OR = 0.999, 95% CI = 0.999–0.999), fruit (OR = 0.998, 95% CI = 0.997–0.999), and green tea (OR = 0.997, 95% CI = 0.994–0.999) were significantly associated with a lower risk of breast cancer. For luminal breast cancer patients, beans (OR = 0.997, 95% CI = 0.994–0.999), white meat (OR = 0.992, 95% CI = 0.987–0.997), green tea (OR = 0.995, 95% CI = 0.991–0.999), and milk (OR = 0.998, 95% CI = 0.996–0.999) were protective factors. While for nonluminal breast cancer, red meat was not included in the equation, and beans (OR = 0.989, 95% CI = 0.981–0.997), white meat (OR = 0.989, 95% CI = 0.981–0.998), vegetables (OR = 0.998, 95% CI = 0.997–0.999), and milk (OR = 0.994, 95% CI = 0.989–0.999) still showed a significantly reduced risk of nonluminal breast cancer. Different dietary factors revealed different effects on the etiology of breast cancer. Red meat may be a specific risk factor for luminal‐type breast cancer.
Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity
Authors: Quarta Alessandra , Meese Tim , Pieters Zoë , Van Breedam Elise , Le Blon Debbie , Van Broeckhoven Jana , Hendrix Sven , Goossens Herman , Hens Niel , Berneman Zwi , Van Nieuwerburgh Filip , Ponsaerts Peter 
Published: August 2020

AbstractCellular models of induced pluripotent stem cell (iPSC)‐derived microglia and macrophages are an emerging toolbox to investigate neuroinflammation in vitro. We previously demonstrated that murine iPSC‐microglia and iPSC‐macrophages display phenotypical activation properties highly comparable to microglia and macrophages in vivo. Here we extended the characterization of iPSC‐microglia and iPSC‐macrophages with the analysis of their transcriptome profile. Next, these cellular models were employed to evaluate neuroimmune toxicity in vitro and to investigate the immune‐modulatory properties of interleukin 13 (IL13), a cytokine known for its ability to protect against neuroinflammation‐induced pathology by modulating microglia and macrophage activation. iPSC‐microglia and iPSC‐macrophages, in co‐culture with astrocyte‐committed neural stem cells (NSC), were (pre)treated with IL13 and stimulated with lipopolysaccharide (LPS) and interferon γ (IFNγ), to assess how IL13 modulates their inflammatory response. Additionally, the use of luciferase‐expressing NSC (Luc‐NSC) allowed real‐time monitoring of immune‐mediated neurotoxicity. Despite the known anti‐inflammatory properties of IL13, iPSC‐microglia primed with IL13 before LPS + IFNγ stimulation significantly increased NO secretion. This was associated with a marked reduction of the luminescence signal produced by Luc‐NSC. Interestingly, we observed that IL13 signaling has a divergent functional outcome in microglia as compared to macrophages, as for the latter no major alterations in NO release and Luc‐NSC viability were observed upon IL13 (pre)treatment. Finally, the striking IL13‐induced upregulation of NO secretion by microglia under pro‐inflammatory conditions was confirmed in vivo, where intracerebral delivery of IL13 increased inducible nitric oxide synthase mRNA expression. Concluding, we applied iPSC‐derived neuroimmune cell culture models to identify distinct neuroimmune (toxicity) responses of microglia and macrophages to IL13‐based immune modulation.
Assessment of haptic memory using somatosensory change‐related cortical responses
Authors: Sugiyama Shunsuke , Kinukawa Tomoaki , Takeuchi Nobuyuki , Nishihara Makoto , Shioiri Toshiki , Inui Koji 
Published: August 2020

AbstractHaptic memory briefly retains somatosensory information for later use; however, how and which cortical areas are affected by haptic memory remain unclear. We used change‐related cortical responses to investigate the relationship between the somatosensory cortex and haptic memory objectively. Electrical pulses, at 50 Hz with a duration of 500 ms, were randomly applied to the second, third, and fourth fingers of the right and left hands at an even probability every 800 ms. Each stimulus was labeled as D (preceded by a different side) or S (preceded by the same side). The D stimuli were further classified into 1D, 2D, and 3D, according to the number of different preceding stimuli. The S stimuli were similarly divided into 1S and 2S. The somatosensory‐evoked magnetic fields obtained were divided into four components via a dipole analysis, and each component's amplitudes were measured using the source strength waveform. The results showed that the preceding event did not affect the amplitude of the earliest 20–30 ms response in the primary somatosensory cortex. However, in the subsequent three components, the cortical activity amplitude was largest in 3D, followed by 2D, 1D, and S. These results indicate that such modulatory effects occurred somewhere in the somatosensory processing pathway higher than Brodmann's area 3b. To the best of our knowledge, this is the first study to demonstrate the existence of haptic memory for somatosensory laterality and its impact on the somatosensory cortex using change‐related cortical responses without contamination from peripheral effects.
Use of intraoperative neural monitoring for prognostication of recovery of vocal mobility and reduction of permanent vocal paralysis after thyroidectomy
Authors: Thong Gerard , Brophy Catherine , Sheahan Patrick 
Published: August 2020

AbstractIntroductionThe benefits of intraoperative neural monitoring (IONM) of recurrent laryngeal nerve (RLN) on post‐thyroidectomy vocal cord palsy (VCP) rates are contentious. We wished to study impact of IONM on permanent VCP after thyroidectomy.MethodsRetrospective review of prospective series of 1011 (1539 nerves‐at‐risk) patients undergoing thyroidectomy without (418, group 1) and with (583, group 2) IONM.ResultsThere were three recognized nerve injuries in group 1, vs one in group 2 (P = .3). There were no differences in overall VCP rates. However, patients in group 2 with immediate postoperative VCP had higher likelihood of full recovery than patients in group 1 (55 of 56 vs 23 of 29 patients, P = .01), and lower incidence of total permanent VCP (2 of 917 vs 9 of 647 patients, P = .01).ConclusionAmong patients with immediate postoperative VCP after thyroidectomy, IONM is associated with a higher likelihood of regaining normal vocal function. This may be related to better identification of RLN branching in IONM cases.