bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA NEAT1 mediates MPTP/MPP+-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease
Authors: Liu Jiyao , Liu Defang , Zhao Bo , Jia Cunwei , Lv Yunli , Liao Jun , Li Kai 
Published: September 2020

AbstractAccumulating evidence suggests that dysregulation of long non-coding RNAs is closely associated with various human diseases, including Parkinson’s disease (PD). However, the role of nuclear-enriched abundant transcript 1 (NEAT1) in the PD process remains unclear. The number of TH+ cells was reduced, and the expression levels of NEAT1 and Krüppel-like factor 4 (KLF4) were increased in the midbrain of MPTP-HCl-treated mice. In addition, the expression of cleaved-caspase-3 (cleaved-casp-3) and Bax (apoptosis-related proteins) was increased, while the expression of Bcl-2 (anti-apoptotic protein) was reduced in MPTP-HCl-treated mice. The expression levels of NEAT1 and KLF4 were increased in MPP+-treated SH-SY5Y cells. Knockdown of NEAT1 promoted cell viability and decreased apoptosis in MPP+-treated SH-SY5Y cells, which could be reversed by upregulating KLF4. KLF4 was verified as a direct target of miR-124, and miR-124 could particularly bind to NEAT1. Downregulation of NEAT1 significantly increased cell viability and decreased apoptosis by regulating miR-124 expression in MPP+-treated SH-SY5Y cells. Additionally, interference of NEAT1 increased the number of TH+ cells and miR-124 expression, while reduced apoptosis and expression of KLF4 in vivo. NEAT1 knockdown increased cell viability and suppressed apoptosis in PD via regulating the miR-124/KLF4 axis, providing a promising avenue for the treatment of PD.
Procedural and Judicial Guarantees Against the Punitive Power of Public Bodies
Authors: Martini Giovanni 
Published: September 2020

Abstract
The scope of this analysis is to reconstruct, with a brief look to the Italian case, the ‘frame of reference’ within which the rulings of the ECtHR on the Art. 6 of the ECHR, due to the particular strength that Article 46 of the Convention attributes to them, are made, to understand, at the outcome, how, and to what extent, the sanctioning activity of public bodies can be influenced by the principles of the ECHR as enforced by the Judges of Strasbourg. To this aim the focus will be addressed on the following, and more complex, profiles: (a) independence, impartiality and separation of functions; (b) sanctioning activity and discretionary powers; (c) sufficient judicial review and full jurisdiction, to conclude the investigation trying to verify, in the light of the latest directions taken by the ECtHR; (d) whether, and how, the types of sanctions can affect the conditions of the judicial protection.
Die archaischen Listen aus Uruk und die proto-keilschriftlichefrontier.Überlegungen zu Funktion und Genese des ältesten lexikalischen Corpus’
Authors: Gabriel Gösta Ingvar 
Published: September 2020

AbstractAlthough the archaic lists are of the utmost importance, as they mark the beginning of the 3,000-year lexical tradition in ancient Mesopotamia, their function is largely unresolved. This contribution suggests that a key to their understanding can be found in the context of a transforming and expanding writing system that is still rooted in administrative practices. The success of the new bureaucratic notation system leads to an expansion of its administrative use, which in turn leads to a demand for more signs and sign combinations. The lexical corpus is the result of a systematic push of the proto-cuneiformfrontier—i. e. the range of what can be expressed through proto-cuneiform signs. The lists thus offer a range ofexploratory signsthat can be implemented for administrative purposes and also have the potential to go beyond bureaucracy. In addition, they exemplify the rules underlying the systematic exploration of the potential of (proto-)cuneiform, thus contributing to the further transformation of the writing system.
Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid
Authors: De Luca Mariarosaria , Iacono Olimpia , Lucci Rosa , Guardasole Vincenzo , Bosso Giorgio , Cittadini Antonio , Oliviero Ugo 
Published: September 2020

Abstract

Objectives
Rhabdomyolysis is a rare syndrome in which a serious muscle damage suddenly appears, with the possible occurrence of severe complications such as kidney failure, electrolyte imbalances and death, and represents the most severe form of statin-induced muscle injury.

Case presentation
Here we present the case of a 55-year-old woman who started therapy with amoxicillin clavulanic acid on a background of atorvastatin therapy, resulting in rhabdomyolysis.

Conclusions
This case highlights the importance of evaluating potential drug interactions in patients taking statin and the need of monitoring clinical and laboratory findings suggestive of rhabdomyolysis.
Is COVID-19 spreading and curing silently: an observation of three family clusters in Bangladesh
Authors: Hoq Mohammad Injamul , Hossain Md. Mohotasin , Roshni Umme Sayma , Sayeed Mohammed Aktar , Tohura Saraban , Jakaria Md. 
Published: September 2020

Abstract

Objectives
The number of coronavirus disease (COVID-19) cases is increasing in Bangladesh. Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. However, they might be spreading their infections among their family members and perhaps in the community. It is unsure that individuals with COVID-19-like symptoms are positive with COVID-19, but our concern is, during this pandemic, any types of symptoms such as flu-like symptoms should have been taken seriously. This study was observed in the cases from three families with COVID-19 like symptoms.

Case presentation
This observational study was done between May 20 and Jun 2, 2020, in Bangladesh. The members of the inspected families shared COVID-19 like symptoms that were lasted for 3-10 days.

Conclusions
COVID-19 might be spread and cured silently in Bangladesh, which recommends that awareness is needed throughout the country to prevent the spreading of the disease.
Local finiteness of the twisted Bruhat orders on affine Weyl groups
Authors: Wang Weijia 
Published: September 2020

Abstract
In this paper, we investigate various properties of strong and weak twisted Bruhat orders on a Coxeter group.
In particular, we prove that any twisted strong Bruhat order on an affine Weyl group is locally finite, strengthening a result of Dyer [Quotients of twisted Bruhat orders,
J. Algebra 163 1994, 3, 861–879].
We also show that, for a non-finite and non-cofinite biclosed set B in the positive system of an affine root system with rank greater than 2, the set of elements having a fixed B-twisted length is infinite.
This implies that the twisted strong and weak Bruhat orders have an infinite antichain in those cases.
Finally, we show that twisted weak Bruhat order can be applied to the study of the tope poset of an infinite oriented matroid arising from an affine root system.
Satirical Novels of the Late Enlightenment and the Practice of Fiction. A Methodological Proposal for Investigations Into the History of Fiction
Authors: Descher Stefan 
Published: September 2020

AbstractThe paper examines German satirical novels of the late Enlightenment period, published roughly between 1760 and 1790, under the following question: Is there any evidence that the historical practice of fiction (concerning this time and these texts) deviates from the modern practice of fiction as described by institutional accounts of fictionality? First, it is explained what, in this essay, is meant by the ›modern practice of fiction‹. Four ›core rules‹ are identified that, according to institutional accounts of fictionality, characterize the practice of reading works of fiction. These core rules are: You should not conclude that what is expressed by fictional utterances is actually true! You should not conclude that the author believes that what is expressed by his fictional utterances is actually true! You should imagine what is expressed by fictional utterances (make-believe, pretence)! You should (or at least can) make your imaginations the object of higher-level attitudes (for example you can evaluate, emotionally respond to, interpret them etc.)! Then, using the example of German satirical novels of the late Enlightenment, seven features of fictional texts are discussed that may provide clues about the historical practice of fiction and that could give an indication of whether the core rules actually do apply. These features are: assurances of truthfulness by the author or fictional authors/editors; direct thematization of the fictional/factual-text-distinction; fictional reading scenarios; comments by fictional narrators and/or characters on the practice of reading; statements of the actual author in the fictional text; ›that cannot be true‹-passages (intentional mistakes, anachronisms, various ways of breaking the reader’s expectations, etc.); various kinds of reference to the actual world (for example satirical allusions to actual persons or states of affairs). It will be argued that, for the corpus of texts under consideration, there is no convincing evidence that the historical practices of reading works of fiction deviates in any significant way from the core rules of the modern practice of fiction. However, the main aim of this paper is not to provide an exhaustive historical case study. First, the investigation is limited to the exemplary discussion of some (although significant) texts and text passages, so the results can only be considered preliminary. Second, while the satirical novel of the late Enlightenment indeed is a particularly interesting and revealing genre for the study of the historical practice of fiction (arguments are given in section 3), the main purpose of this essay is to make amethodologicalproposal. Ageneral procedureis provided for finding out whether the historical practice of fiction differs from our modern practice – a procedure that can be applied to texts of other times and genres as well.
Hybrid buffer‐based optical packet switch with negative acknowledgment for multilevel data centers
Authors: Chandra Sumit , Fatima Shahnaz , Singh Suryavanshi Raghuraj 
Published: September 2020

Abstract
In the present scenario, data centers serve many functionalities like storage, transfer of data, supporting web applications, etc. In data centers, various levels of hierarchy different types of switches are required; therefore, multifunctional data centers are desired. This paper discusses a novel design for optical switch which can be placed at various levels of hierarchy. In the proposed design, multifunctionality contention resolution schemes which consider electronic and optical buffering and all-optical negative acknowledgment (AO-NACK) are considered. In buffering technologies, contending packets are stored in either in electronic RAM or in fiber delay lines. In case of the AO-NACK scheme, contending packets are blocked, and a negative acknowledgment is sent back to the transmitting node and blocked packets are retransmitted. For various considered schemes, Monte Carlo simulation have been performed, results in terms of packet loss probability are presented, and it has been found that the performance of optical buffering is much superior to electronic buffering and AO-NACK schemes. It is found that, in the AO-NACK scheme, the numbers of retransmitted packets due to contention blocking are 33,304 which can be reduced to 7, by using a small amount of buffer at each node.
Does the length of second stage of labour or second stage caesarean section in nulliparous women increase the risk of preterm birth in subsequent pregnancies?
Authors: Liu Cathy Z. , Ho Nicole , Tanaka Keisuke , Lehner Christoph , Sekar Renuka , Amoako Akwasi A. 
Published: September 2020

Abstract

Objectives
This study aimed to investigate the role of prolonged second stage of labour and second stage caesarean section on the risk of spontaneous preterm birth (sPTB) in a subsequent pregnancy.

Methods
This was a retrospective cohort study of nulliparous women with two consecutive singleton deliveries between 2014 and 2017 at a tertiary centre. In the vaginal delivery cohort, subsequent pregnancy outcomes for women with a prolonged second stage (>2 h) were compared with those with a normal second stage (≤2 h). In the caesarean delivery cohort, women with a first stage or a second stage were compared with the vaginal delivery cohort. The primary outcome was subsequent sPTB.

Results
A total of 821 women met inclusion criteria, of which 74.8% (614/821) delivered vaginally and 25.2% (207/821) delivered by caesarean section. There was no association between a prolonged second stage in the index pregnancy and subsequent sPTB (aOR 0.70, 95% CI 0.13–3.83, p=0.7). The risk of subsequent sPTB was threefold for those with a second stage caesarean section; however this did not reach statistical significance.

Conclusions
A prolonged second stage of labour in the index pregnancy is not associated with an increased risk of subsequent sPTB. A second stage caesarean section in the index pregnancy may be associated with an increased risk of subsequent sPTB, however there was no statistically significant difference. These findings are important for counseling and suggest that the effects of these factors are not clinically significant to justify additional interventions in the subsequent pregnancy.
Foul accumulation in the NBA
Authors: Chu Dani , Swartz Tim B. 
Published: September 2020

Abstract
This paper investigates the fouling time distribution of players in the National Basketball Association. A Bayesian analysis is presented based on the assumption that fouling time distributions follow a gamma distribution. Various insights are obtained including the observation that players accumulate fouls at a rate that increases with the current number of fouls. We demonstrate possible ways to incorporate the fouling time distributions to provide decision support to coaches in the management of playing time.
Ursprünge transzendentaler Ästhetik. Zum Wandel von Kants Raum- und Zeitargumentation von derInauguraldissertation zurKritik
Authors: Martin Christian 
Published: September 2020

AbstractAccording to a widespread view, the essentials of Kant’s critical conception of space and time as set forth in the Transcendental Aesthetic can already be found in his 1770 Inaugural Dissertation. Contrary to this assumption, the present article shows that Kant’s later arguments for the a priori intuitive character of our original representations of space and time differ crucially from those contained in the Dissertation. This article highlights profound differences between Kant’s transcendental and his pre-critical conception of pure sensibility by systematically comparing the topic, method and argumentation of the First Critique with that of the Inaugural Dissertation. It thus contributes to a better understanding of the Transcendental Aesthetics itself, which allows one to distinguish its peculiar transcendental mode of argumentation from considerations made by the pre-critical Kant, with which it can easily be conflated.
Changes in the productivity of word-formation patterns: Some methodological remarks
Authors: Berg Kristian 
Published: September 2020

AbstractChanges in the productivity of word-formation patterns are often investigated using hapax legomena. In this paper, I argue that at least in diachronic investigations of productivity, a measure based on first attestations is a viable alternative to hapax-based measures. I show that such a measure is a more direct proxy to new words than hapax-based measures – it measures what we want to measure, which is not always true for the latter. I present a method that deals with the common problem of varying subcorpus sizes (I suggest we randomly resample the subcorpora up to a predefined size), and to the problem of old words appearing as new at the start of the corpus (I suggest we take an earlier corpus and determine a point in time when almost all old words have registered). Armed with these instruments, we can determine the ratio of new types to existing types for a time span, which can be regarded as the renewal rate of the respective category.
The first report of albinism in a Sundaland endemic rodent
Authors: Nations Jonathan A. , Mursyid Ahmad , Darma Busta Ryski , Adrian Sah Putra , Handika Heru , Apandi  , Achmadi Anang S. , Esselstyn Jacob A. 
Published: September 2020

Abstract
Albinism, a congenital disorder that results in a lack of melanin deposition, is common in domesticated animals but rare in nature. Among the ∼2500 species of rodents worldwide, only 67 have published reports of albinism. Here we report the capture of an albino murid (Muridae: Rodentia) from Mt. Singgalang in West Sumatra, Indonesia. The specimen is an adolescent but sexually mature male Maxomys hylomyoides, a montane Sumatran endemic. To our knowledge, this specimen represents the first reported albino rodent from Indonesia and Sundaland, and only the second from Southeast Asia.
An immune-relevant signature of nine genes as a prognostic biomarker in patients with gastric carcinoma
Authors: Wang Bing , Zhang Yang 
Published: September 2020

Abstract

Background
As one of the most common malignant tumors worldwide, the morbidity and mortality of gastric carcinoma (GC) are gradually increasing. The aim of this study was to construct a signature according to immune-relevant genes to predict the survival outcome of GC patients using The Cancer Genome Altas (TCGA).

Methods
Univariate Cox regression analysis was used to assess the relationship between immune-relevant genes regarding the prognosis of patients with GC. The least absolute shrinkage and selection operator (LASSO) Cox regression model was used to select prognostic immune-relevant genes and to establish the signature for the prognostic evaluation of patients with GC. Multivariate Cox regression analysis and Kaplan–Meier survival analysis were used to assess the independent prognostic ability of the immune-relevant gene signature.

Results
A total of 113 prognostic immune-relevant genes were identified using univariate Cox proportional hazards regression analysis. A signature of nine immune-relevant genes was constructed using the LASSO Cox regression. The GC samples were assigned to two groups (low- and high risk) according to the optimal cutoff value of the signature score. Compared with the patients in the high-risk group, patients in the low-risk group had a significantly better prognosis in the TCGA and GSE84437 cohorts (log-rank test P < 0.001). Multivariate Cox regression analysis demonstrated that the signature of nine immune-relevant genes might serve as an independent predictor of GC.

Conclusions
Our results showed that the signature of nine immune-relevant genes may potentially serve as a prognostic prediction for patients with GC, which may contribute to the decision-making of personalized treatment for the patients.
Evaluating the use of a tactile sensor for measuring carton compliance
Authors: Eriksson Daniel , Loeb Gerald E. , Persson Camilla , Korin Christer 
Published: September 2020

Abstract
This work reports the evaluation of a tactile sensor for the potential of using it to measure the compliance of folding cartons. A tactile sensor would make it possible to measure the mechanical behavior locally around the contact point, in contrast to existing methods that measure the global mechanical behavior of the carton. Research on the haptic sense has shown that the local mechanical behavior is more important than the global behavior when humans assess compliance of objects. It is shown that the response of the tactile sensor correlates strongly with the bending stiffness of the board, but also with geometric features. A method for reducing the 22-dimensional output of the sensor to single meaningful feature using linear discriminant analysis is proposed and tested. The results show that the sensor is a good candidate for a method that incorporates both cutaneous and kinaesthetic information in the measure of carton compliance.
Effects of Ag contents on the microstructure and SERS performance of self-grown Ag nanoparticles/Mo–Ag alloy films
Authors: Lian Xinxin , Lv Yuanjiang , Sun Haoliang , Hui David , Wang Guangxin 
Published: September 2020

Abstract
Ag nanoparticles/Mo–Ag alloy films with different Ag contents were prepared on polyimide by magnetron sputtering. The effects of Ag contents on the microstructure of self-grown Ag nanoparticles/Mo–Ag alloy films were investigated using XRD, FESEM, EDS and TEM. The Ag content plays an important role in the size and number of uniformly distributed Ag nanoparticles spontaneously formed on the Mo–Ag alloy film surface, and the morphology of the self-grown Ag nanoparticles has changed significantly. Additionally, it is worth noting that the Ag nanoparticles/Mo–Ag alloy films covered by a thin Ag film exhibits highly sensitive surface-enhanced Raman scattering (SERS) performance. The electric field distributions were calculated using finite-difference time-domain analysis to further prove that the SERS enhancement of the films is mainly determined by “hot spots” in the interparticle gap between Ag nanoparticles. The detection limit of the Ag film/Ag nanoparticles/Mo–Ag alloy film for Rhodamine 6G probe molecules was 5 × 10−14 mol/L. Therefore, the novel type of the Ag film/Ag nanoparticles/Mo–Ag alloy film can be used as an ideal SERS-active substrate for low-cost and large-scale production.
A Preliminary Study Interrogating the Cataloging and Classification Schemes of a K-12 Book Discovery Platform through a Critical Race Theory Lens
Authors: Kumasi Kafi D. , Jimes Cynthia , Godwin Amee Evans , Petrides Lisa A. , Karaglani Anastasia 
Published: September 2020

AbstractThis article presents the results of a preliminary study to examine the cataloging and classification schemes and ideological factors that play out in book discovery platforms for children’s and young adult books. Using Critical Race Theory and a Rapid Contextual Design approach to exploring the curatorial behaviors of school librarians when searching for diverse books, the study offers design ideas for retooling discovery platforms in ways that bridge the cultural disconnect that young adults from historically marginalized racial backgrounds experience in their libraries. The article concludes that in order for school librarians to find, recommend and teach about books that reflect race, equity and inclusion themes, they need more sophisticated and user-centered features that reflect critical race and multicultural analytic frameworks. This includes the need for a common vocabulary around issues of race, equity and inclusion that can simultaneously cut through the ambiguity of social tagging and yet subvert the status quo of entrenched liberalism and/or racially biased ideologies embedded in traditional classification schemes and hierarchies, such as those used in Library of Congress subject headings. The findings further suggest that school librarians would benefit from enhanced education and training in the intersections of cataloging, classification and critical race scholarship.