bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to validate radiopharmaceuticals management software?
Authors: Léa De Neef , Damien Peyronnet , Blondeel-Gomes Sandy 
Published: October 2020

AbstractIn the context of securing medication management systems (MMS) in healthcare habilities, implementation of an electronic MMS is a priority area of work. The quality requirements for the production of radiopharmaceuticals have increased significantly in the field of radiopharmacy. The deployment of Information Technology (IT) tools is essential to secure the radiopharmaceutical medication use process. The aim of this work is to propose the first consensual tool to validate radiopharmacy software approved by a panel of experts. A literature review was conduced related to the validation of hospital pharmacy software. The Delphi method was chosen for achieving a consensus in this study. Surveys were sent by mail to selected experts involved in the MMS. Twenty-seven replies were recorded (77%) to the first round, and 17 responses were recorded to the second survey. The final tool is a grid with 44 items. We proposed the first consensual tool to validate radiopharmacy software. This tool could be implemented in all French radiopharmacy to improve quality.
Impact of reinforcement on shrinkage in the concrete floors of a residential building
Authors: Raczkiewicz Wioletta , Wójcicki Artur 
Published: October 2020

Abstract
The type of floor in a building object results from the serviceability requirements, technical possibilities, and costs of its implementation. Concrete screeds constituting the structural layer of the floor can be made without reinforcement, with dispersed reinforcement, or reinforced with meshes of various materials. Due to the large surface dimensions, concrete screeds are susceptible to scratches as a result of occurring strains, service loads and unevenness of the floor. There are detailed recommendations on how to make floors, and on the materials used. However, the conditions in which floors are made often differ from those recommended. The article presents the results of measured strains on the surfaces of three screeds constituting the floor layer in a residential building. The screeds, which were made in identical environmental conditions, differed in the type of reinforcement used: steel mesh, dispersed polypropylene fibres, fibreglass mesh. In addition, strain measurements were carried out on concrete and fibre-reinforced concrete specimens made of the mix used to make the screeds. The results allowed the assessment of the effectiveness of the reinforcement used, the impact of environmental conditions on the values, and the analysis of differences in the course of strains in real elements and the specimens.
Plasma Membrane Fusion Is Specifically Impacted by the Molecular Structure of Membrane Sterols During Vegetative Development of Neurospora crassa
Authors: Weichert Martin , Herzog Stephanie , Robson Sarah-Anne , Brandt Raphael , Priegnitz Bert-Ewald , Brandt Ulrike , Schulz Stefan , Fleißner André 
Published: October 2020

Abstract
Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. In particular, the step of plasma membrane merger and the contributing proteins and physicochemical factors remain mostly unknown. Earlier studies provided the first evidence of a role of membrane sterols in cell-to-cell fusion. By characterizing different ergosterol biosynthesis mutants of the fungus Neurospora crassa, which accumulate different ergosterol precursors, we show that the structure of the sterol ring system specifically affects plasma membrane merger during the fusion of vegetative spore germlings. Genetic analyses pinpoint this defect to an event prior to engagement of the fusion machinery. Strikingly, this effect is not observed during sexual fusion, suggesting that the specific sterol precursors do not generally block membrane merger, but rather impair subcellular processes exclusively mediating fusion of vegetative cells. At a colony-wide level, the altered structure of the sterol ring system affects a subset of differentiation processes, including vegetative sporulation and steps before and after fertilization during sexual propagation. Together, these observations corroborate the notion that the accumulation of particular sterol precursors has very specific effects on defined cellular processes rather than nonspecifically disturbing membrane functioning. Given the phenotypic similarities of the ergosterol biosynthesis mutants of N. crassa during vegetative fusion and of Saccharomyces cerevisiae cells undergoing mating, our data support the idea that yeast mating is evolutionarily and mechanistically more closely related to vegetative than sexual fusion of filamentous fungi.
PURIFICATION AND CHARACTERIZATION OF AN ENDOGLUCANASE PRODUCED FROM Streptomyces sp. STRAINBPNG23
Authors: BETTACHE Azzeddine , Estelle Copinet , Azzouz Zahra , Boucherba Nawel , Bouiche Celia , Hamma Samir , Maibeche Rima , Duchiron Francis , Benallaoua Said 
Published: October 2020

Streptomyces sp. strain BPNG23 produces five endoglucanases: endo1, endo 2, endo 3, endo 4 and endo 5.The endo2 has been purified and characterized by two subsequent purification steps with ultrafiltration and anion exchange chromatography. The specific activity of the endoglucanase has been found to be 380.65 U/mg. The molecular weight to the endoglucanase 2 has been estimated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, revealing that this isoenzyme is a 66 KDa monomeric enzyme. It showed an optimum temperature and pH values respectively of 6.0 and 50 °C. It was thermostable, it exhibited a half-life time 6 h with a temperature of 50 °C, the enzyme was activated by several metal ions Mn+2, NH4+, Zn2+, Ca2+, Fe2+, Ni2+ and Co2+. It presents a higher affinity towards carboxymethyl cellulose (CMC) with a Km of 6.37 mg/mL and Vmax of 0.056 μmol/mn. This the first of a study of purification and characterization of an endoglucanase produced by a newly isolated actinobacteria strain in Kabylia region (Algeria).
A neurotrofikus tropomiozin receptor-tirozin-kináz génfúziót tartalmazó daganatok diagnosztikai megközelítése
Authors: Lippai Zoltán , Sápi Zoltán 
Published: October 2020

Absztrakt:
A neurotrofikus tropomiozin receptor-tirozin-kináz (NTRK-)
géncsalád tagjai (NTRK1, NTRK2, NTRK3) által kódolt tropomiozin
receptor-tirozin-kináz fehérjék (TrkA, TrkB, TrkC) fiziológiásan elsősorban az
idegsejtek fejlődéséért, éréséért, működéséért felelősek. Az
NTRK-géncsaládot érintő genetikai eltérések, melyek a
leggyakrabban kromoszomális transzlokáció következtében jönnek létre, számos
rosszindulatú daganat kialakulásához vezethetnek. Egyes, kifejezetten ritka
daganatokban nagyon nagy gyakorisággal fedezhető fel valamelyik
NTRK-fúziós gén létrejötte, mint például az infantilis
fibrosarcoma, a congenitalis mesoblastos nephroma vagy a secretoros carcinoma,
míg egyes gyakori daganatokban – vastagbélrák, tüdőrák – bár kisebb
frekvenciával, de szintén megjelenhet. Az utóbbi időben vizsgált, rendkívül
magas válaszadási aránnyal alkalmazott ’target’ terápia miatt az
NTRK-fúziós gének diagnosztikája még nagyobb jelentőségűvé
vált. A cikk összegzi mindazokat a diagnosztikai eljárásokat s azok előnyeit,
illetve hátrányait, melyeknek szerepük van az NTRK-géneltérések
felderítésében, valamint ezek alapján további diagnosztikai megfontolásokat
fogalmaz meg, melyek segíthetnek egy adott esetben a megfelelő diagnosztikai
módszer megválasztásában. Orv Hetil. 2020; 161(41): 1753–1763.
Heg nélküli pajzsmirigyműtét – a TOETVA mint új eljárás a hazai pajzsmirigysebészetben
Authors: Lévay Bernadett , Oberna Ferenc 
Published: October 2020

Absztrakt:
Bevezetés és célkitűzés: A pajzsmirigyműtétek során a nyakon jól
látható és nehezen takarható heg keletkezik, mely a páciensek életminőségét
hosszú távon befolyásolhatja. Az elmúlt két évtizedben számtalan, minimálisan
invazív műtéti behatolást dolgoztak ki, amelyek méretben csökkentették, vagy
kevésbé látható régióba helyezték a pajzsmirigyműtétek hegeit. A módszerek
sokszínűsége azt jelzi, hogy egyik eljárás sem tudta megfelelően biztosítani az
elvárt klinikai és kozmetikai eredményt. A természetes testnyílásokon keresztül
végzett műtétek látható heg nélküli gyógyulást eredményeznek. A szájüregi
behatolásból kidolgozott műtétek közül a szájon (vestibulum oris) keresztüli
thyreoidectomia (TOETVA – transoral endoscopic thyroidectomy vestibular
approach) bizonyult a legbiztonságosabb és legjobb eredményt adó műtéti
eljárásnak. Indikációs területét a kisebb méretű cisztás pajzsmirigylebenyek,
göbös lebenyek, kisebb méretű papillaris carcinoma, valamint a
mellékpajzsmirigy-adenoma adják. Módszer: Az Országos
Onkológiai Intézet Fej-nyaki Daganatok Multidiszciplináris Központjában 2018.
06. 12. és 2020. 02. 18. között 7 betegen végeztünk pajzsmirigyműtétet szájon
keresztüli behatolásból, endoszkópos technikával. A szövettani vizsgálat 4
esetben papillaris carcinomát, 2 esetben follicularis adenomát, illetve 1
esetben benignus kolloid göböt véleményezett. Az 10–30 mm-es képletek
eltávolítása 1 esetben isthmectomiával, 6 esetben lobectomiával történt.
Eredmények: Műtét során 2 esetben kényszerültünk vérzés
miatti konverzióra. Az 5, endoszkópos műtét végén drént nem helyeztünk be,
betegeinket az 1. posztoperatív napon hazabocsátottuk. A két, konvertált műtétes
pácienst a 2. posztoperatív napon, a nyaki drén eltávolítását követően
emittáltuk. A daganatok eltávolítása a hisztológia alapján megfelelt az
onkológiai elveknek, a nervus recurrens sérülését vagy egyéb szövődményt nem
észleltünk. Az átlagos műtéti idő 127 perc volt. Következtetés:
A TOETVA a pajzsmirigy-eltávolítás egyetlen olyan műtéti módszere, amely külső
heggel nem jár, keloidképződést nem okoz. 15–20 műtétben adják meg a tanulási
fázist, mely után a műtéti idő csökken. Biztonságos és eredményes
kivitelezéséhez azonban nagyszámú nyitott pajzsmirigyműtétet végzett,
endoszkópos sebészetben is gyakorlott specialista szükséges. Orv Hetil. 2020;
161(41): 1764–1768.
Does SARS-CoV-2 Infect the Kidney?
Authors: Khan Shaza , Chen Lihe , Yang Chin-Rang , Raghuram Viswanathan , Khundmiri Syed J. , Knepper Mark A. 
Published: October 2020

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/JASN/2020_11_24_JASN2020081229.mp3
Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region
Authors: Smith Danielle , Adams Larissa , Du Randt Rosa , Degen Jan , Gall Stefanie , Joubert Nandi , Müller Ivan , Nqweniso Siphesihle , Pühse Uwe , Steinmann Peter , Utzinger Juerg , Walter Cheryl , Gerber Markus 
Published: October 2020

Background: Information about the relationships between physical fitness, body composition and nutrition has increased in recent years; however, little is known about physical fitness and the coexistence of under-/overnutrition among children living in disadvantaged areas.
Objectives: To determine the physical fitness status and its association with body composition, growth and selected socio- demographics in primary schoolchildren from disadvantaged communities in the Nelson Mandela Bay region.
Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body mass index, and height-for-age z-scores. Physical fitness was assessed using tests from the Eurofit Physical Fitness test battery (flexibility, upper/lower body muscular strength and cardiorespiratory fitness). Between- group differences and cross-sectional associations were examined with univariate (Chi2-tests, analyses of variance) and multivariate methods (mixed linear/logistic regression).
Results: Most children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p<0.001). Overweight/obese children had lower scores in weight-bearing activities (p<0.001). Children with higher socio-economic status were more likely to be overweight and obese (p<0.001). In the multivariate analyses, sex, age, body mass index, and stunting were associated with children’s physical fitness.
Conclusion: Fitness assessments seem to be a relevant measure of the current health status of children in disadvantaged settings. Compared to international norms, the children in this study had relatively low scores for both upper- and lower body muscular strength. Therefore, effective school-based intervention programmes should be developed to improve children’s physical fitness in disadvantaged schools.
Construcción y validación del instrumento Equidad Laboral NOGOCO, en docentes de Institutos Tecnológicos Superiores de Quito Ecuador
Authors: Noroña Salcedo Darwin Raúl , González Baltazar Raquel 
Published: October 2020

Objetivo: Construir y validar un instrumento de medición de percepción de equidad laboral en docentes.
Métodos: Se realizó un estudio mixto secuencial derivativo cuali-cuantitativo. Se consiguió describir y caracterizar estas experiencias en razón de 23 listados de códigos agrupados en 7 categorías. Con esta aproximación de la población y definición de la equidad laboral, se diseñó el instrumento de equidad laboral NOGOCO. Se redactaron 147 ítems que corresponden a los segmentos de códigos más frecuentes en las entrevistas a profundidad, asegurando su validez lógica y de contenido. Se aplicaron estas preguntas a 735 docentes para el análisis de fiabilidad del alpha de Cronbach. Se realizó el análisis de constructo con: la reducción factorial de los ítems, prueba de KMO y de esfericidad de Barlett con rotación varimax.
Resultados: El análisis de fiabilidad del Alpha de Cronbach fue de 0.97; la correlación del elemento total corregido permitió confirmar 44 ítems y descartar 103. Con el análisis factorial exploratorio, los ítems se agruparon en 10 factores que explican el 46.5% de la varianza total acumulada. La adaptación de la escala se calculó con base a los percentiles 33 y 66. Los factores finales del Instrumento NOGOCO fueron: autoritarismo, equidad de las remuneraciones, trato a las personas, reconocimiento, igualdad, dedicación, interés en la gente, justicia, discriminación y salud.
Conclusión: El instrumento NOGOCO, es el primer instrumento de medición de percepción de la equidad laboral con validez de contenido, consistencia interna y de constructo.
The role of physical activity on blood factors, lipid profile, and liver enzymes of tile factory workers (A Case Study)
Authors: Dashti khavidaki MH , Minaeifar AA , Rassekh F , Baghiani A 
Published: October 2020

Introduction: Inhalation of dust particles is prone to chronic diseases, and regular exercise reduces the risk of cardiovascular disease and improves blood variables. The purpose of this study was to investigate the role of physical activity on blood factors, lipid profile, and liver enzymes in tile factory workers.
Materials and Methods: This is a cross-sectional study. 70 workers who were eligible to participate in the study were selected based on the sampling method available at the workplace. According to the Beck questionnaire, 15 people were included in each active and inactive groups. After 12 hours of worker's last meal, 10 ml of venous blood was used to evaluate biochemical variables of Blood factors (RBC, Hematocrit, Hemoglobin, WBC), lipid profile (Cholesterol, Triglyceride). Liver enzyme (ALT, AST, ALP) tests of both groups were performed in the occupational medicine laboratory of Meybod city, and SPSS Ver.23 software was used for analysis.
Results: The results showed that red blood cells (p = 0.003) and hemoglobin (p = 0.034) in the active group were significantly higher than the inactive group. Also triglyceride (p = 0.025) and cholesterol (p = 0.042) of liver enzymes, (p = 0.011) ALT and AST (p = 0.047) were significantly lower.
Conclusion: It seems that physical activity can have a positive effect; it can improve blood factors, liver enzymes, and fat profile in workers. According to the results, tile factory workers can achieve the desired blood factors with minimal physical activity.
Pragmatıc Dıscourse of Pagaralamnese Imperatıve Polıteness And Its Englısh Meanıng Based Translatıon
Authors: RONI RUSMAN 
Published: October 2020

The current study is focused on the imperative politeness used by Pagaralamnese.The objective of this study was to find out the categories of imperative politeness in Pagaralamnese and its cultural translation into English. The method usedwas a qualitative ethnography of communication and the instruments utilyzed were wdct( written discourse completion task) and an interview. There were five respondents of Pagaralamnese. The interactive model was used in analyzing the data. The findings showed that there were six types of taboo words in Pagaralamnesenamely imperative politeness of warning, request, order, prohibition, suggestion., expectation.This article deals with discourses of imperative politeness found in various places in Indonesia. By using data collected from five respondents from Pagaralam city with socio pragmatic approach. Thoughsomereseachers claim that politenese expressions were translated in a certain lexicon withouth context , the fact that politeness expressions should be translated in a context or in a pragmatic way. In addition, it is strongly recommended to translate politeness expressions in a cultural context
Nature Of Media Diplomacy In Influencing Foreign Policy Decision Making Process In Kenya
Authors: Aduol Odiemo Festus , Godfrey Okoth Prof. Pontian 
Published: October 2020

The media's diplomatic function has been studied in relation to the advanced communication technologies that have led to the allocation of a more far- reaching role to the media in the conduct of diplomacy. The main research gap that this study aims at covering lies in the actual media diplomacy influence on the foreign policy decision making process at implementation phase. Despite the attention given to the media's potential to affect foreign policy decisions, their involvement is still confined to a largely instrumental role and more importantly, one that influences the process of decision making, rather than the decision outcomes. This study analysed media diplomacy influence on foreign policy decision making process in Kenya at implementation phase. The objective of this study was to examine the nature of media diplomacy in influencing foreign policy decision making process in Kenya. It is established that media plays a complementary role to diplomacy in foreign policy implementation and hence shapes the outcome of foreign policy in Kenya. The article concludes that media diplomacy can play a significant role in the foreign policy implementation. The study hence recommends that Kenya should establish a strong regional media network, an effective diplomatic strategy to bridge the gaps in foreign policy process and train diplomats on effective media relations.
The Impact of Deep Brain Stimulation on the Cognitive Ability of Patients with Parkinson Disease
Authors: Liu Kuo 
Published: October 2020

<p>Deep Brain Stimulation, especially STN-DBS, is one of the most prevalent treatments for the Parkinson’s Disease. Previous researches already showed its positive effects on the general conditions of the patients but lack evaluation of its influence on the cognitive ability of the patients. A comparison in the effect of DBS and surgical lesioning procedures can determine DBS’s influence on the quality of life and confirm whether it is the most optimal treatment. This proposal reviewed previous researches about the influence of STN-DBS and proposed a study on its influence of patients’ cognitive ability.</p>
O ESTADO DO PIAUÍ NA EXPOSIÇÃO NACIONAL DE 1908
Authors: SILVA LAILA PEDROSA DA 
Published: October 2020

No início do século XX, as exposições foram percebidas como importantes instrumentos de modernização nacional, bem como de identificação dos recursos naturais do país, a fim de apontar suas possíveis possibilidades de uso. As elites políticas, econômicas e intelectuais piauienses passaram a defender o comparecimento do Piauí nas mostras expositivas, acreditando que traria inúmeros benefícios para a região, tais como investimentos de capitais estrangeiros e melhoramentos nas suas indústrias econômicas. Dessa forma, a proposta deste artigo é descrever e analisar a participação do Piauí na Exposição Nacional de 1908, realizada em comemoração ao primeiro centenário da abertura dos portos às nações amigas. A partir de periódicos locais, mensagens governamentais e catálogos dos produtos expostos, percebemos que a exposição foi oportuna para divulgação das potencialidades econômicas do estado que, desde a segunda metade do século XIX, se via na fronteira do progresso e reclamava maior atenção das autoridades governamentais.
Palavras-chave: Piauí. Exposição. Integração.
KARAKTERISTIK KIMIA DAN ORGANOLPETIK PEMPEK LENJER KECIL KERING DENGAN PERLAKUAN KONSENTRASI CaCl2
Authors: Alhanannasir Alhanannasir , Murtado Asep Dodo 
Published: October 2020

As an authentic food of Palembang people in South Sumatera Province, pempek is famous local food caused of unique color (yellowish-white color), flavor (fishy flavor), and chewy texture. Pempek as semi-wet food that can be dried to decrease water content and increase the shelf life. Dried pempek has a lighter and smaller volume material and making it easier to distribute and expand marketing. Pempek can be prepared from ground fish (cork fish), tapioca flour, salt, and water. These ingredients are mixed to form a dough. Pempek dough can be formed into a small pempek, such as lenjer, pastel, otak-otak, adaan, keriting, and kapal selam. Pempek is generally has a wet form. Wet pempek has a high water content of 50-60%, so it had shelf life about 3-4 days. Therefore, wet pempek must be dried to make it long shelf life. The aim of the research was to know about small dried pempek lenjer characteristic based on various addition of CaCl2. The treatment of various CaCl2 concentrations has a very significant effect on water content and protein content (chemical value) and significantly influence the organoleptic properties (aroma, color, and taste) of the dried pempek lenjer. The 1.5% concentration of CaCl2 (C3) treatment has the highest average level of likeness on aroma 3.75, color 3.90, and taste 3.95 with preferred criteria on a dried pempek lenjer.
Keywords: chemical, organoleptic, small dried pempek lenjer
ANALISIS POST-HARVEST LOSS PADA OKRA DENGAN METODE OBJECTIVE MATRIX (OMAX) DI PT MITRATANI DUA TUJUH JEMBER
Authors: Suryaningrat Ida Bagus , Prabowo Ferry Julio , Amilia Winda 
Published: October 2020

Post-harvest loss is a process of the loss or the broken material from production in the field to the food being ready to be consumed. Losses in agricultural or horticultural produce are a major problem in the post-harvest process. Therefore, it was needed to identify the criteria based on the post-harvesting process to know the performance level of each criterion provided. This study was aimed to know the post-harvest loss source in the occurrence of the post-harvest process of okra. This research used Objective Matrix method (OMAX) to evaluate the performance level of each criterion provided. AHP method was also implemented in this research by using the pairwise comparison technique to measure the weight on OMAX and fishbone diagram and to identify causes factors of the okra loss. The research result showed that the picking and weighing process during post-harvest okra have lower performance level and it was not meet the expected target of the company (PT Mitratani Dua Tujuh). Other result of okra loss level was also still far from the expected target of the company. The improvement recommendations were needed to reduce post-harvest okra loss, i.e. increasing supervision by the manager, making removal plot during okra harvesting, and briefing every morning with the okra picker.
Keywords: AHP, fishbone diagram, OMAX, post-harvest loss