bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index
Authors: Veugen Christianne C. A. F. M. , Teunissen Emma M. , den Otter Leontine A. S. , Kos Martijn P. , Stokroos Robert J. , Copper Marcel P. 
Published: October 2020

Abstract
Purpose
To evaluate the performance of the NoSAS (neck, obesity, snoring, age, sex) score, the STOP-Bang (snoring, tiredness, observed apneas, blood pressure, body mass index, age, neck circumference, gender) questionnaire, and the Epworth sleepiness score (ESS) as a screening tool for obstructive sleep apnea (OSA) severity based on the apnea-hypopnea index (AHI) and the oxygen desaturation index (ODI).

Methods
Data from 235 patients who were monitored by ambulant polysomnography (PSG) were retrospectively analyzed. OSA severity was classified based on the AHI; similar classification categories were made based on the ODI. Discrimination was assessed by the area under the curve (AUC), while predictive parameters were calculated by four-grid contingency tables.

Results
The NoSAS score and the STOP-Bang questionnaire were both equally adequate screening tools for the AHI and the ODI with AUC ranging from 0.695 to 0.767 and 0.684 to 0.767, respectively. Both questionnaires perform better when used as a continuous variable. The ESS did not show adequate discrimination for screening for OSA (AUC ranging from 0.450 to 0.525). Male gender, age, and BMI proved to be the strongest individual predictors in this cohort.

Conclusion
This is the first study to evaluate the predictive performance of three different screening instruments with respect to both the AHI and the ODI. This is important, due to increasing evidence that the ODI may have a higher reproducibility in the clinical setting. The NoSAS score and the STOP-Bang questionnaire proved to be equally adequate to predict OSA severity based on both the AHI and the ODI.
Effect of continuous positive airway pressure on symptoms of anxiety and depression in patients with obstructive sleep apnea
Authors: Lundetræ Ragnhild Stokke , Saxvig Ingvild West , Lehmann Sverre , Bjorvatn Bjørn 
Published: October 2020

Abstract
Purpose
The objective was to assess the effect of continuous positive airway pressure (CPAP) on symptoms of anxiety and depression in patients with obstructive sleep apnea (OSA). We hypothesized a decrease in symptoms at follow-up, but that improvement relied on CPAP adherence.

Methods
The sample comprised 468 patients (mean age 55.5 years (SD = 12.0), 72% men) with OSA who received CPAP at a Norwegian hospital. OSA was diagnosed according to standard respiratory polygraphy. Mean baseline respiratory event index (REI) was 28.4 (SD = 20.6). Symptoms of anxiety and depression were assessed prior to CPAP treatment and at follow-up after a median of 20 weeks, range 6–52 weeks, with the Hospital Anxiety and Depression Scale (HADS). Patients were classified as CPAP adherent (≥ 4 h per night) or non-adherent (< 4 h per night).

Results
There was a significant decrease in anxiety scores from baseline (mean = 5.16, SD = 3.94) to follow-up (mean = 4.76, SD = 3.81), p < 0.001. Similarly, depression scores decreased from baseline (mean = 4.31, SD = 3.66) to follow-up (mean = 3.89, SD = 3.69), p < 0.001. Cohen’s d (0.19 and 0.18, respectively) indicated small effect sizes. The reduction in anxiety scores did not depend on CPAP adherence (no interaction effect F(1, 466) = 0.422, p = 0.516), whereas the reduction in depression scores were seen only in the CPAP adherent group (interaction effect F(1, 466) = 7.738, p = 0.006).

Conclusions
We found a decrease in symptoms of anxiety and depression from baseline to follow-up of CPAP treatment. The improvement in symptoms of depression was depending on CPAP adherence. This underlines the importance of adherence for optimal effect of CPAP treatment.
Intelligent lightweight structures for hybrid machine tools
Authors: Möhring H. -Christian , Müller Matthias , Krieger Jens , Multhoff Jörg , Plagge Christian , de Wit Jesper , Misch Sandra 
Published: October 2020

AbstractIn order to improve the competitiveness on the global machine tool markets, a permanent development of new solutions and optimization of existing technologies is necessary. Besides traditional business areas, like Europe, Asia and the US, emerging countries provide interesting potential. Currently, the setup and operation of precise machine tools in these areas possesses some challenges. As an example, the foundation of the machines is often not as stable as assumed during the layout and design phase. Furthermore, the thermal boundary conditions are often characterized by much higher differences of the ambient temperature during the daily operational time compared to European conditions. These influences affect especially the performance of medium sized machine tools. Within the joint project HYBRIDi, funded by the Federal Ministry of Education and Research (BMBF) supported by the Projektträger Karlsruhe (PTKA), partners from industry and research created, realized and investigated new intelligent lightweight machine slide structures in order to overcome the named challenges. In particular, two variants of a hybrid material z-slide (RAM) with integrated sensors were built and analyzed with respect to advantages in terms of mass reduction, static and dynamic stiffness, dynamic positioning accuracy as well as thermal behavior. This paper presents the developments and results of the project.
Modeling of vacuum grippers for the design of energy efficient vacuum-based handling processes
Authors: Gabriel Felix , Fahning Markus , Meiners Julia , Dietrich Franz , Dröder Klaus 
Published: October 2020

AbstractVacuum-based handling is widely used in industrial production systems, particularly for hand-ling of sheet metal parts. The process design for such handling tasks is mostly based on approximate calculations and best-practice experience. Due to the lack of detailed knowledge about the parameters that significantly influence the seal and force transmission behavior of vacuum grippers, these uncertainties are encountered by oversizing the gripping system by a defined safety margin. A model-based approach offers the potential to overcome this limitation and to dimension the gripping system based on a more exact prediction of the expected maximum loads and the resulting gripper deformation. In this work, we introduce an experiment-based modeling method that considers the dynamic deformation behavior of vacuum grippers in interaction with the specific gripper-object combination. In addition, we demonstrate that for these specific gripper-object combinations the gripper deformation is reversible up to a certain limit. This motivates to deliberately allow for a gripper deformation within this stability range. Finally, we demonstrate the validity of the proposed modeling method and give an outlook on how this method can be implemented for robot trajectory optimization and, based on that, enable an increase of the energy efficiency of vacuum-based handling of up to 85%.
Putting the French Duty of Vigilance Law in Context: Towards Corporate Accountability for Human Rights Violations in the Global South?
Authors: Schilling-Vacaflor Almut 
Published: October 2020

AbstractThe adoption of the French Duty of Vigilance law has been celebrated as a milestone for advancing the transnational business and human rights regime. The law can contribute to harden corporate accountability by challenging the “separation principle” of transnational companies and by obligating companies to report on their duty of vigilance. However, the question of whether the law actually contributes to human rights and environmental protection along global supply chains requires empirically grounded research that connects processes in home and host state countries. This paper contributes to such a new research agenda by linking political ecology literature and empirical insights from the Global South to research on due diligence regulations. With reference to field research data on contestations between the oil and gas company Total E&P and indigenous communities in Bolivia, I argue that the burden of proof and contestations over valid knowledge represent major obstacles when trying to establish legal liability.
Improving and monitoring the magnetic pulse welding process between dissimilar metals
Authors: Bellmann Joerg , Schettler Sebastian , Schulze Sebastian , Wagner Markus , Standfuss Jens , Zimmermann Martina , Beyer Eckhard , Leyens Christoph 
Published: October 2020

AbstractConventional fusion welding of dissimilar metals is often limited due to the different thermo-physical properties of the joining partners. In consequence, brittle intermetallic phases (IMC) can occur. Utilizing a pressure welding process like magnetic pulse welding (MPW) reduces the risk of IMCs significantly. Furthermore, this welding process has an outstanding short process duration in the range of a few microseconds, which makes it predestined for mass production. At the same time, this advantage challenges the process observation, inline-quality assurance hardware, and the design of the tool coils. The paper presents two strategies for reducing the energy input during MPW to increase the tool coil lifetime. The first approach, the introduction of a reactive nickel interlayer between steel and aluminum, leads to a significant welding energy reduction. Compared to aluminum samples joined by laser welding, the load-bearing capability of the resulting hybrid MPW driveshaft samples is higher in static torsion tests and similar in cyclic tests. The second approach is based on a novel process monitoring system that helps to analyze the characteristic light emission. The capability of the process monitoring system is presented on the example of a MPW-joined multimaterial part made of stainless steel, aluminum, and copper.
Levothyroxine and insulin requirement in autoimmune polyglandular type 3 syndrome: a real-life study
Authors: Guarnotta V. , Pillitteri G. , Gambino G. , Radellini S. , Vigneri E. , Pizzolanti G. , Giordano C. 
Published: October 2020

Abstract
Purpose
To evaluate factors influencing the insulin and levothyroxine requirement in patients with autoimmune polyglandular syndrome type 3 (APS-3) vs. patients with type 1 diabetes mellitus (T1DM) and autoimmune hypothyroidism (AH) alone, respectively.

Methods
Fifty patients with APS-3, 60 patients with T1DM and 40 patients with AH were included. Anthropometric, clinical and biochemical parameters were evaluated in all patients. Insulin requirement was calculated in patients with APS-3 and T1DM, while levothyroxine requirement was calculated in APS-3 and AH.

Results
Patients with APS-3 showed higher age (p = 0.001), age of onset of diabetes (p = 0.006) and TSH (p = 0.004) and lower total insulin as U/day (p < 0.001) and U/Kg (p = 0.001), long-acting insulin as U/day (p = 0.030) and U/kg (p = 0.038) and irisin (p = 0.002) compared to T1DM. Patients with APS-3 had higher waist circumference (p = 0.008), duration of thyroid disease (p = 0.020), levothyroxine total daily dose (p = 0.025) and mcg/kg (p = 0.006), triglycerides (p = 0.007) and VAI (p = 0.010) and lower age of onset of thyroid disease (p = 0.007) than AH.
At multivariate analysis, levothyroxine treatment and VAI were associated with insulin and levothyroxine requirement in APS-3, respectively. VAI was independently associated with insulin requirement in T1DM. Circulating irisin levels were independently associated with levothyroxine requirement in AH.

Conclusion
Patients with APS-3 show lower insulin requirement and higher levothyroxine requirement than T1DM and AH alone, respectively. Levothyroxine treatment and VAI affect insulin and levothyroxine requirement, respectively, in APS-3. In T1DM, adipose tissue dysfunction, indirectly expressed by high VAI, is associated with an increased insulin requirement, while circulating irisin levels influence the levothyroxine requirement in AH.
Adverse pathophysiological influence of early testosterone therapy on the testes of boys with higher grade sex chromosome aneuploidies (HGAs): a retrospective, cross-sectional study
Authors: Spaziani M. , Tarantino C. , Pozza C. , Anzuini A. , Panimolle F. , Papi G. , Gianfrilli D. , Lenzi A. , Radicioni A. F. 
Published: October 2020

AbstractPurposeHigher grade aneuploidies (HGAs) of the male sex chromosomes are a rare genetic group of pathologies caused by nondisjunction meiotic events. The aim of this study was to evaluate the impact of early androgenic therapy on the testicular secretory hormone profile, and the pathophysiological implications.Patients and methodsIn this cross-sectional study, 18 HGA subjects aged 6–8 years were recruited. They were divided into two groups, based on whether or not they had previously undergone testosterone therapy (group 1: 11 untreated subjects; group 2: 7 treated subjects). Serum FSH, LH, testosterone (T), inhibin B (INHB) and anti-Müllerian hormone (AMH) were determined, and auxological parameters were assessed. Five group 1 patients and four group 2 patients were treated with hCG (human chorionic gonadotropin) for inguinal cryptorchidism; their hormone profile and auxological parameters were assessed both pre- and post-hCG treatment.ResultsGroup 1 subjects showed significantly higher testicular volume and higher levels of AMH and INHB (p < 0.0001). Subjects who had undergone hCG therapy showed a significantly higher testicular volume, penis length (respectively,p = 0.008 andp = 0.0005 for group 1 andp = 0.04 andp = 0.001 for group 2) and T (p = 0.005 for group 1 andp = 0.004 for group 2).ConclusionsHGA patients undergoing early testosterone therapy show an earlier and persistent suppression of testicular secretory function. At this age, the testes are still responsive to stimulation with hCG. The selection of patients to be treated must be accompanied by a thorough clinical and hormonal evaluation.
Geomorphic and Sedimentary Effects of Modern Climate Change: Current and Anticipated Future Conditions in the Western United States
Authors: East Amy E. , Sankey Joel B. 
Published: October 2020

AbstractHydroclimatic changes associated with global warming over the past 50 years have been documented widely, but physical landscape responses are poorly understood thus far. Detecting sedimentary and geomorphic signals of modern climate change presents challenges owing to short record lengths, difficulty resolving signals in stochastic natural systems, influences of land use and tectonic activity, long‐lasting effects of individual extreme events, and variable connectivity in sediment‐routing systems. We review existing literature to investigate the nature and extent of sedimentary and geomorphic responses to modern climate change, focusing on the western United States, a region with generally high relief and high sediment yield likely to be sensitive to climatic forcing. Based on fundamental geomorphic theory and empirical evidence from other regions, we anticipate climate‐driven changes to slope stability, watershed sediment yields, fluvial morphology, and aeolian sediment mobilization in the western United States. We find evidence for recent climate‐driven changes to slope stability and increased aeolian dune and dust activity, whereas changes in sediment yields and fluvial morphology have been linked more commonly to nonclimatic drivers thus far. Detecting effects of climate change will require better understanding how landscape response scales with disturbance, how lag times and hysteresis operate within sedimentary systems, and how to distinguish the relative influence and feedbacks of superimposed disturbances. The ability to constrain geomorphic and sedimentary response to rapidly progressing climate change has widespread implications for human health and safety, infrastructure, water security, economics, and ecosystem resilience.
Oak Transpiration Drawn From the Weathered Bedrock Vadose Zone in the Summer Dry Season
Authors: Hahm W. J. , Rempe D. M. , Dralle D. N. , Dawson T. E. , Dietrich W. E. 
Published: October 2020

AbstractThe spatiotemporal dynamics of plant water sources are hidden and poorly understood. We document water source use of Quercus garryana growing in Northern California on a profile of approximately 50 cm of soil underlain by 2–4 m of weathered bedrock (sheared shale mélange) that completely saturates in winter, when the oaks lack leaves, and progressively dries over the summer. We determined oak water sources by combining observations of water stable isotope composition, vadose zone moisture and groundwater dynamics, and metrics of tree water status (potential) and use (sapflow). During the spring, oak xylem water is isotopically similar to the seasonal groundwater and shallow, evaporatively enriched soil moisture pools. However, as soils dry and the water table recedes to the permanently saturated, anoxic, low‐conductivity fresh bedrock boundary, Q. garryana shifts to using a water source with a depleted isotopic composition that matches residual moisture in the deep soil and underlying weathered bedrock vadose zone. Sapflow rates remain high as late‐summer predawn water potentials drop below −2.5 MPa. Neutron probe surveys reveal late‐summer rock moisture declines under the oaks in contrast to constant rock moisture levels under grass‐dominated areas. We therefore conclude that the oaks temporarily use seasonal groundwater when it occupies the weathered profile but otherwise use deep unsaturated zone moisture after seasonal groundwater recedes. The ample moisture, connected porosity, and oxygenated conditions of the weathered bedrock vadose zone make it a key tree water resource during the long summer dry season of the local Mediterranean climate.
Constraining Remote River Discharge Estimation Using Reach‐Scale Geomorphology
Authors: Brinkerhoff C. B. , Gleason C. J. , Feng D. , Lin P. 
Published: October 2020

AbstractRecent advances in remote sensing and the upcoming launch of the joint NASA/CNES/CSA/UKSA Surface Water and Ocean Topography (SWOT) satellite point toward improved river discharge estimates in ungauged basins. Existing discharge methods rely on “prior river knowledge” to infer parameters not directly measured from space. Here, we show that discharge estimation is improved by classifying and parameterizing rivers based on their unique geomorphology and hydraulics. Using over 370,000 in situ hydraulic observations as training data, we test unsupervised learning and an “expert” method to assign these hydraulics and geomorphology to rivers via remote sensing. This intervention, along with updates to model physics, constitutes a new method we term “geoBAM,” an update of the Bayesian At‐many‐stations hydraulic geometry‐Manning's (BAM) algorithm. We tested geoBAM on Landsat imagery over more than 7,500 rivers (108 are gauged) in Canada's Mackenzie River basin and on simulated hydraulic data for 19 rivers that mimic SWOT observations without measurement error. geoBAM yielded considerable improvement over BAM, improving the median Nash‐Sutcliffe efficiency (NSE) for the Mackenzie River from −0.05 to 0.26 and from 0.16 to 0.46 for the SWOT rivers. Further, NSE improved by at least 0.10 in 78/108 gauged Mackenzie rivers and 8/19 SWOT rivers. We attribute geoBAM improvement to parameterizing rivers by type rather than globally, but prediction accuracy worsens if parameters are misassigned. This method is easily mapped to rivers at the global scale and paves the way for improving future discharge estimates, especially when coupled with hydrologic models.
Strategies for Simplifying Reactive Transport Models: A Bayesian Model Comparison
Authors: Schäfer Rodrigues Silva Aline , Guthke Anneli , Höge Marvin , Cirpka Olaf A. , Nowak Wolfgang 
Published: October 2020

AbstractFor simulating reactive transport on aquifer scale, various modeling approaches have been proposed. They vary considerably in their computational demands and in the amount of data needed for their calibration. Typically, the more complex a model is, the more data are required to sufficiently constrain its parameters. In this study, we assess a set of five models that simulate aerobic respiration and denitrification in a heterogeneous aquifer at quasi steady state. In a probabilistic framework, we test whether simplified approaches can be used as alternatives to the most detailed model. The simplifications are achieved by neglecting processes such as dispersion or biomass dynamics, or by replacing spatial discretization with travel‐time‐based coordinates. We use the model justifiability analysis proposed by Schöniger, Illman, et al. (2015, https://doi.org/10.1016/j.jhydrol.2015.07.047) to determine how similar the simplified models are to the reference model. This analysis rests on the principles of Bayesian model selection and performs a tradeoff between goodness‐of‐fit to reference data and model complexity, which is important for the reliability of predictions. Results show that, in principle, the simplified models are able to reproduce the predictions of the reference model in the considered scenario. Yet, it became evident that it can be challenging to define appropriate ranges for effective parameters of simplified models. This issue can lead to overly wide predictive distributions, which counteract the apparent simplicity of the models. We found that performing the justifiability analysis on the case of model simplification is an objective and comprehensive approach to assess the suitability of candidate models with different levels of detail.
Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice
Authors: Zhou Han , Qian Xiaoyun , Xu Nana , Zhang Shasha , Zhu Guangjie , Zhang Yuan , Liu Dingding , Cheng Cheng , Zhu Xiaocheng , Liu Yongze , Lu Ling , Tang Jie , Chai Renjie , Gao Xia 
Published: October 2020

AbstractAtg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium damage, somatic electromotility disturbances, and presynaptic ribbon degeneration over time, which led to the gradual wholesale loss of OHCs and subsequent early-onset profound hearing loss. Impaired autophagy disrupted OHC mitochondrial function and triggered the accumulation of dysfunctional mitochondria that would otherwise be eliminated in a timely manner. Atg7-independent autophagy/mitophagy processes could not compensate for Atg7 deficiency and failed to rescue the terminally differentiated, non-proliferating OHCs. Our results show that OHCs orchestrate intricate nonselective and selective autophagic/mitophagy pathways working in concert to maintain cellular homeostasis. Overall, our results demonstrate that Atg7-dependent autophagy plays a pivotal cytoprotective role in preserving OHCs and maintaining hearing function.