bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytoconstituents and biological analysis of Acorus calamus rhizome of Sindhupalchowk District, Nepal
Authors: Pokhrel Shanta , Chaulagain Kalpana 
Published: December 2019

Phytochemical and biological activities of methanolic and hexane extract of Acorus calamus rhizome were carried out. Phytochemical analysis showed the presence of flavonoid, glycoside, saponin, resin and carbohydrates which are responsible for the antibacterial activities. The antibacterial potential was studied against Staphylococcus aureus (gram positive bacteria) and Escherichia coli, Salmonella typhi (gram negative bacteria) using Agar Well Diffusion Method. The activity was shown by both methanolic and hexane extract of Acorus calamus rhizome against both Gram positive and Gram negative bacteria. Antioxidant activity of methanolic extract was evaluated by 2, 2-diphenyl-1-picryl hydrazyl (DPPH) free radical scavenging activity showed potent antioxidant activities with IC50 value 3.74 μg/mL slightly higher than standard ascorbic acid (IC50 = 3.56 μg/mL).
BIBECHANA 17 (2020) 104-109
The Physicochemical analysis and Phytochemical screening of some medicinal plants of Letang Municipality of Morang district, Nepal
Authors: Chaudhary Narendra Kumar , Ojha Rijan , Gautam Tilak Prasad 
Published: December 2019

Ethnobotany gives the basic idea about the medicinal properties of plants. Identification of active compounds of the medicinal plants and their standardization is essential for the production of new drugs. In the present work, different parts of the five medicinal plants (Curcuma caesia, Costus speciosus, Drymaria cordata, Leea macrophylla, Plumbago zeylanica) were washed, air dried and crushed. Three different extracts of each powdered material were prepared and standard phytochemical analysis procedure was followed for the analysis of physicochemical properties of plants and the identification of active chemical constituents. Among 5 plants, the highest moisture content (14.83%) was found in Plumbago zeylanica, higher total ash (9.22%) and acid insoluble ash (4.43%) were observed in Cucurma caesia. Phytochemical analysis revealed the presence of 12 varieties of bioactive chemicals in the 5 different plants. The plants of the area have great diversity of phytochemicals of numerous medicinal properties. In conclusions, these five important medicinal plants could be useful for the people of the locality to cure several diseases as well as to generate the source of income.
BIBECHANA 17 (2020) 67-74
Hydrophobicity of small alkane molecules (propane dimer) in solvents: a classical molecular dynamics study
Authors: Panthi Bikash , Pantha Nurapati 
Published: December 2019

Molecular Dynamics (MD) simulations of propane dimer in different solvents (water, acetonitrile and methanol) were performed by using CHARMM platform for modeling the solute and solvents. A series of Umbrella sampling MD simulations were carried out in each solvent separately and potential of mean force (PMFs) were calculated by using Weighted Histogram Analysis Method. Results show that two minima (contact minima and solvent separated minima) characterize the PMF of propane dimer in all three solvent environments. The contact minima are deeper and less sensitive to solvent environment for its position. However, significant effect in the position of second minima, solvent separated minima, was observed. Our study reveals that the interaction between propane dimer is softer in methanol and acetonitrile than in water.
BIBECHANA 17 (2020) 1-12
Constant velocity pulling and unfolding of thyroid hormone receptor by steered molecular dynamics
Authors: Lamichhane Tika Ram , Lamichhane Hari Prasad 
Published: December 2019

Unfolding pathways of T3 liganded thyroid hormone receptor (THRT3) can be studied by using the protocols of steered molecular dynamics (SMD). Theory of constant velocity pulling has been implemented to the structure of THRT3 in a neutral water-ion solution equilibrated up to 20 ns. The globular form of THRT3 is completely unfolded extending N-C termini from 38 Å to 876 Å at a constant speed of 0.1 Å/ps by means of 8.5 ns long SMD simulations. The peak force measured in the intermediate conformations is related to a burst of backbone H-bonds among a-helices and b-hairpins. With decrease in H-bonds, electrostatic energy increases by losing gradually the secondary structure and separating a and b-strands in solution. The force at the end (t > 8.5 ns) increases steeply with the large increase in bond-angle and bond-length potentials when the system becomes completely unfolded. The hydrophobic ligand binding domain (LBD) of THR-b with load bearing H-bonds protects T3 from water attack. Even after complete unfolding of THR-b LBD, the position of T3 is not deviated more than 2.5 Å and a large number of water molecules remain in the surrounding of this domain area. This is a strong evidence for the mechanochemical stability of a receptor protein’s LBD towards hormone activated gene expressions followed by ligand binding and dissociation.
BIBECHANA 17 (2020) 50-57
Variation of Total Electron Content (TEC) in the Quite and Disturbed days and their correlation with Geomagnetic Parameters of Lamjung Station in the year of 2015
Authors: Ghimire Basu Dev , Chapagain Narayan Prasad , Basnet Vardhan , Bhatta Karan , Khadka Balaram 
Published: December 2019

Total Electron content is measured using a dual frequency GPS receiver in Lamgung (LMJG) Station located at 84.57° longitude and 28.17° latitude of the year 2015 as it is considered as geo-magnetically active year. In this study, diurnal variation of VTEC has been studied separately for quiet and disturbed days and, for the effective study of the case the PRN wise data of VTEC have been also used. The maximum VTEC is seen from 0700 LT to 1100 LT (LT=UT+5.45). PRN wise VTEC is studied taking the lower bound (LB) and upper bound (UB). The correlation of VTEC with Dst index, Kp index and Solar flux have been studied. Positive correlation has been found in disturbed days with Kp index and solar flux but negative correlation with Dst index. Dst index shows positive correlation in quiet days but Kp index shows negative correlation.
BIBECHANA 17(2020) 123-132
PENGARUH DISIPLIN KERJA TERHADAP PRODUKTIVITAS KERJA KARYAWAN PT PERKEBUNAN NUSANTARA IV (PERSERO) UNIT USAHA PABATU
Authors: Andini Yulia , Lubis Yusniar , Siregar Rahma Sari 
Published: December 2019

<p>This study was conducted to determine the effect of work discipline on employee productivity at PT. Perkebunan Nusantara IV (Persero) Pabatu Business Unit. The population in this study were all employees of the department, engineering / processing, and general at PT. Perkebunan Nusantara IV (Persero) Unit Business Unit is 1031 people. the number of respondents used in this study were 104 people. The research was obtained from the results of the t test on the variables obeying all company regulations, namely 2.652&gt; T table = 1.980 stating that complying with all company regulations had a positive and significant effect on employee work productivity. Effective use of time is 3,069 &lt;Ttable = 1,980 stating that effective use of time has a positive and significant effect on employee work productivity variables. Responsibility for work and assignments is 5,467&gt; T table = 1.980 states that work responsibilities and tasks have positive and significant to employee work productivity. The absentee level of 1,200 &lt;Ttable = 1,980 has a positive and insignificant effect on employee work productivity. The simultaneous test results obtained are 262.880&gt; 2.31, which states that work discipline simultaneously has a positive and significant effect on employee work productivity. And the R value obtained is 0.884. This figure shows that 88.4% of work productivity is explained by the variable work discipline.</p>
Monetary policy under economic transformation in Ukraine
Authors: Pasichnyi Mykola 
Published: December 2019

The research subject includes the theoretical basis and mechanisms of monetary policy formation and realization as an instrument of macroeconomic regulation. The aim of the study is to determine the features of domestic monetary policy and to systemize the policy’s stages under economic transformations. Methods. In order to achieve the appropriate tasks, we used a set of methods and approaches, that helped to ensure the conceptual unity of our investigation. The dialectical, systemic and structural approaches, methods of analysis and synthesis, comparison, generalization, scientific abstraction are applied. Results. The peculiarities of formation and realization of monetary policy of Ukraine under economic transformations are determined. The main stages of national monetary policy’s development are systemized. The dynamics of monetization, exchange rate and index of consumer price from 1992 to 2018 is investigated. Practical implications. Monetaryl policy and instruments of its implementation. Conclusions. Nowadays, the monetary policy has a formed institutional mechanism in order to reach the main goal and tasks. We identified the main phases of monetary policy of Ukraine. In the initial stage the main elements of monetary architectonics are established, also the powers and tasks of central bank are defined. The stage of functional improvement characterized by the restriction on central bank repayment of bonds on the primary market, decreasing the monetization of national economy, introducing the currency exchange corridor. At the steady development phase, we determined the exchange rate stability and gradual increasing of monetization level. Within the transitional stage of modification, the raising of monetization was continued, moreover, the combined using of methods on the currency market was carried out to stabilize it. Also, National bank defined the priority directions to enhance the bank system. The stage of institutional modernization is characterized by the monetary strategy formation, increasing the central bank institutional and financial independence, the adoption of inflation targeting regime, the improving of basic statements of currency transaction, the developing of macroprudential regulation to ensure financial stability.
The new trends in human resource management in the context of the economy digitalization
Authors: Vankevich Alena 
Published: December 2019

The subject of research is the changes of human resources management at the micro level in the conditions of the economy digitalization. The main directions of the transformation of the labor market in the economy digitalization conditions are the following: expansion of labor supply due to participation in economic activity of various socio-demographic groups of the population; increase in the volume of information about the labor market and its openness due to electronic resources; industry changes in the structure of the labor demand; the jobs polarization; the rapid renewal of professions and skills; the reduction of traditional sectors of the economy; the break of the national labor markets borders. It has been substantiated that these transformations change the requirements for the human resources management service in organizations and modify their functions. The main trends of the human resource management changes in the digitalization conditions are highlighted - the development of employment analysis under Big Data analytics; increased attenion to the formation of the HR- brand; changing the organizational role of the human resources department at the micro level; more active using the staff outsourcing; digitalization of human resource management technologies; expansion of interaction HR-departments and educational institutions, anticipating future skills and competencies; increasing the requirements for the HR manager, especially professional HR-specialists. As a result of the study, the directions for the formation of modern human resources departments in the organizations of the Republic of Belarus were determined, taking into account the course taken by the country to digitalization of the economy.
Some Relations Between the Riemann Zeta Function and the Generalized Bernoulli Polynomials of Level $m$
Authors: QUİNTANA Yamilet , TORRES-GUZMÁN Héctor 
Published: December 2019

The main purpose of this paper is to show some relations between the Riemann zeta function and the generalized Bernoulli polynomials of level $m$. Our approach is based on the use of Fourier expansions for the periodic generalized Bernoulli functions of level $m$, as well as quadrature formulae of Euler-Maclaurin type. Some illustrative examples involving such relations are also given.
Deletions in metastatic colorectal cancer with chromothripsis
Authors: Skuja E. , Butane D. , Nakazawa-Miklasevica M. , Daneberga Z. , Purkalne G. , Miklasevics E. 
Published: December 2019

Summary. Aim: In our previously reported study, we found a correlation between DNA massive fragmentation and increased progression free survival (PFS) in metastatic colorectal cancer (mCRC), but not overall survival. The aim of this study is to find overlapping deleted genome regions in selected mCRC patients with chromothripsis and detect possible cause of increased PFS, and find new genes or combinations, involved in colorectal cancer oncogenesis. Materials and Methods: 10 mCRC patients with chromothripsis receiving 5-fluorouracil, oxaliplatin, leucovorin (FOLFOX) first-line palliative chemotherapy between August, 2011 and October, 2012 were selected for this study. Microarray analysis was performed using the Infinium HumanOmniExpress-12 v1.0 formalin-fixed paraffin-embedded (FFPE) BeadChip kit (Illumina). BeadChip was scaned on HiScan (Illumina). Analysis was performed by GenomeStudio software (Illumina) and R version 3.1.2. Copy number variation and breakpoints on the chromosomes were analyzed using the DNA copy package. Results: Eight deleted tumor suppressor genes (ROBO2, CADM2, FAT4, PCDH10, PCDH18, CDH18, TSG1, CTNNA3) and four deleted oncogenes (CDH12, GPM6A, ADAM29, COL11A1) were identified in more than half of patients. In 70% patients’ deletion in COL11A1 was detected. Deletion of MIR1269, MIR4465, MIR1261 and MIR4490 in patients with longer time to progression was observed. Four patients (40%) with PFS over 14 months, presented with NRG3 deletion (oncogene, еpidermal growth factor receptor (EGFR) ligand) what could possibly decrease proliferation of cancer cells via decreasing EGFR activation. Conclusions: Multiple chromosomal deletions (MIR1269, NRG3, ADK) in mCRC patients with chromothripsis are associated with better response to first line palliative FOLFOX-type chemotherapy and increased PFS.
How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy
Authors: Skrypnyk I. , Maslova G. , Lymanets T. , Gusachenko I. 
Published: December 2019

Summary. Aim: To evaluate the quality of life (QoL) parameters in patients with acute leukemia (AL) during standard induction chemotherapy, depending on the presence of concomitant ischemic heart disease and to improve them by the prevention of anthracycline cardiotoxicity with L-arginine. Materials and Methods: A total of 147 adult AL patients (72 males and 75 females with the mean age 54.7 ± 9.3 years) were enrolled in the study. QoL assessment was performed at baseline and after induction chemotherapy using SF-36 questionnaire. Both physical and mental parameters were evaluated. Results: The QoL analysis of patients with AL at the time of initial diagnosis showed extremely low QoL level in all subgroups compared with healthy individuals. It should be noted that the level of patients’ QoL after achieving remission remained significantly lower than those of practically healthy, which is primarily due to the need for further long-term treatment and, probably, the fear of the disease relapse development. It was found that the administration of L-arginine during induction chemotherapy in order to reduce the risk of anthracycline cardiotoxicity development has allowed improving the QoL in patients with concomitant ischemic heart disease. Conclusion: L-arginine decreases the risk of anthracycline-induced myocardial injury and improves QoL in AL patients.
Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79,524 patients from Latvia
Authors: Gavars D. , Perminov D. , Tauckels E. , Lindenberga I. , Auce A. , Lejniece S. 
Published: December 2019

Summary. Aim: Currently there are some large-scale studies of elevated total vitamin B12 in relation to diseases and their prognosis. Aim of this retrospective study was to determine association of increased B12 as an additional diagnostic marker of oncohematological diseases by a statistical analysis of clinical data of 79,524 patients. Materials and Methods: Overall Latvian population representative data on B12 testing in 79,524 patients were obtained from laboratory database. The following exclusion criteria were applied: fluctuating B12 results within a three-month period, elevated (> 100 U/L) alanine transaminase or aspartate transaminase, hepatitis (HAV, HBV, and HCV) infection, reduced glomerular filtration rate (< 45 mL/min/1.73 m2). As a control group, individuals with normal B12 level and any oncologic diagnosis (solid cancer or hematological malignancies) were selected. Results: After application of step-by-step exclusion filters, 1,373 patients were left with significantly increased level of plasma B12 (> 1,700 pg/mL). Odds ratios for oncohematological diseases in total and myeloid leukemia (including acute, chronic and unspecified) in patient group with elevated B12 were found to be 6.0 (95% CI 4.7–7.6; p < 0.0001) and 19.2 (95% CI 13.1–28.0; p <0.0001), respectively, as compared to the control group. Conclusion: Elevated total B12 could be considered as a potential marker for oncohematological disorders.
The role of the European Swimming Federations in the protection of athletes’ health and the promotion of health in the general population
Authors: Pérez-Díaz C , De la Cruz-Márquez JC , Rico-Castro N , Cueto-Martín B 
Published: December 2019

Objective: To determine the profile of the medical personnel, priorities and activities/researches of the European National Swimming Federations respect to the protection of their athletes’ health and their role in the promotion of health in the general population.

Method: A cross-sectional descriptive survey was circulated among the 51 European National Swimming Federations requesting information regarding the profile of the medical personnel of the federations, the importance they place on the health of their athletes, the promotion of health in their societies and about the activities/research programmes that they engage in to promote health.
Results: The results show that 58.9% of the European National Swimming Federations have doctors and 64.1% have physiotherapists. For 51.2% of federations the top priority is the performance of their elite athletes and only 10.2% of them have as a priority to improve the health of the general population. Conclusions: Overall, European National Swimming Federations have appropriate medical personal within their federation or National teams. However, they have reported that health promotion is not a top priority for them. There is a need to improve their general health promotion programmes. Plans and strategies could be implemented in order to promote health in the general population.
Anthropometric profile of sedentary women with and without hypothyroidism
Authors: Azevêdo Luan Morais , Fernandes de Oliveira Manuella , Adães Motta dos Santos Aline Da Silva , Mota Márcio Rabelo , Pardono Emerson 
Published: December 2019

Objective: To compare the anthropometric characteristics of sedentary women beginners in a physical exercise program in the gym, which had clinical diagnosis of hypothyroidism, with women who did not have hypothyroidism.
Methods: The sample consisted of eighty women aged between 23 and 45 years who started in a gym at an interval of two years and who had hypothyroidism and the control group, without this pathology, selected in a simple random way. Anthropometric measurements, such as body mass, height, body mass index, abdominal circumference and waist, and body fat percentage were performed. Student's t-test was applied for independent samples between groups and Pearson correlation within groups. The statistical significance adopted was p < 0.05.
Results: The group with hypothyroidism showed significant difference (p = 0.05) compared to control group for the body fat percentage just for women above 35 years, just like women with hypothyroidism above 35 years showed strong association of anthropometric variables with waist hip ratio (r ≥ 0.70).
Conclusion: Sedentary women, above 35 years and affected by hypothyroidism, showed greater association of anthropometric variables with the predisposition to the risk of developing cardiovascular disease compared to their peers without the condition, and below this age range.
Efeito do exercício de alongamento estático passivo contínuo versus fracionado sobre a força muscular
Authors: Barbosa-Netto S , Almeida MB 
Published: December 2019

Objetivo: Verificar o efeito do exercício de alongamento estático passivo realizado sob dois protocolos (fracionado versus contínuo) com a mesma duração, sobre o número de repetições máximas com carga habitualmente utilizada nas sessões de treino para dez repetições no supino reto com barra livre.
Método: Um grupo de 16 homens (idade: 23.4 ± 2.8 anos; massa corporal: 81.8 ± 10.4 kg; estatura: 178.7 ± 2.6 cm) treinados e assintomáticos, que foram submetidos aos protocolos fracionado e contínuo. Para a análise dos efeitos dos exercícios de alongamento sobre a capacidade de gerar força foi utilizada a ANOVA para medidas repetidas com post hoc de Bonferroni.
Resultados: Não houve diminuição no desempenho no teste de repetições máximas, independentemente da situação testada (p = 0.842). Em todos protocolos, os indivíduos executaram em média 17 repetições máximas (desvio‐padrão variando entre 2.9‐3.6 repetições máximas), sem diferença entre si.
Conclusão: Executar um exercício de alongamento estático passivo durante 60 s, seja ele fracionado ou contínuo, não diminui o desempenho no teste de repetições máximas em relação à condição sem alongamento prévio.
Validade e fidedignidade de escalas de apoio social e autoeficácia para atividade física em escolares
Authors: Bacil EDA , Piola TS , Mazzardo O , Rech CR , Legnani RFS , Campos W 
Published: December 2019

Objetivo: Analisar a validade e a fidedignidade (reprodutibilidade e consistência interna) das escalas de apoio social e autoeficácia para atividade física em escolares de 9‐15 anos.
Método: Participaram do estudo 1678 escolares para a etapa de validade e consistência interna e 1393 para reprodutibilidade, de ambos os sexos, de Curitiba, Brasil. A validade foi verificada pela análise fatorial exploratória, a reprodutibilidade pelo coeficiente de correlação intraclasse e a consistência interna pelo alpha de Cronbach.
Resultados: As escalas de apoio social e autoeficácia para atividade física apresentaram dois fatores com cargas fatoriais iguais ou superiores a 0.40 para todos os itens em todas as idades. Os escores de reprodutibilidade foram adequados em todas as faixas etárias analisadas para as medidas de apoio social para atividade física (≥ 0.81) e autoeficácia para atividade física (≥ 0.72). A consistência interna para a escala de apoio social variou entre 0.87‐0.90 e para a escala de autoeficácia para atividade física de 0.77‐0.82. Conclusões: As escalas demonstraram validade fatorial satisfatória e reprodutibilidade e consistência interna adequadas, sendo recomendadas a sua utilização em estudos com escolares entre 9‐15 anos de idade.