bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model-Based Inference of Punctuated Molecular Evolution
Authors: Manceau Marc , Marin Julie , Morlon Hélène , Lambert Amaury 
Published: June 2020

AbstractIn standard models of molecular evolution, DNA sequences evolve through asynchronous substitutions according to Poisson processes with a constant rate (called the molecular clock) or a rate that can vary (relaxed clock). However, DNA sequences can also undergo episodes of fast divergence that will appear as synchronous substitutions affecting several sites simultaneously at the macroevolutionary timescale. Here, we develop a model, which we call the Relaxed Clock with Spikes model, combining basal, clock-like molecular substitutions with episodes of fast divergence called spikes arising at speciation events. Given a multiple sequence alignment and its time-calibrated species phylogeny, our model is able to detect speciation events (including hidden ones) cooccurring with spike events and to estimate the probability and amplitude of these spikes on the phylogeny. We identify the conditions under which spikes can be distinguished from the natural variance of the clock-like component of molecular substitutions and from variations of the clock. We apply the method to genes underlying snake venom proteins and identify several spikes at gene-specific locations in the phylogeny. This work should pave the way for analyses relying on whole genomes to inform on modes of species diversification.
3′-Terminal 2′-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2
Authors: Liang Hongwei , Jiao Zichen , Rong Weiwei , Qu Shuang , Liao Zhicong , Sun Xinlei , Wei Yao , Zhao Quan , Wang Jun , Liu Yuan , Chen Xi , Wang Tao , Zhang Chen-Yu , Zen Ke 
Published: June 2020

Abstract
Methylation of miRNAs at the 2′-hydroxyl group on the ribose at 3′-end (2′-O-methylation, 2′Ome) is critical for miRNA function in plants and Drosophila. Whether this methylation phenomenon exists for mammalian miRNA remains unknown. Through LC–MS/MS analysis, we discover that majority of miR-21-5p isolated from human non-small cell lung cancer (NSCLC) tissue possesses 3′-terminal 2′Ome. Predominant 3′-terminal 2′Ome of miR-21-5p in cancer tissue is confirmed by qRT-PCR and northern blot after oxidation/β-elimination procedure. Cancerous and the paired non-cancerous lung tissue miRNAs display different pattern of 3′-terminal 2′Ome. We further identify HENMT1 as the methyltransferase responsible for 3′-terminal 2′Ome of mammalian miRNAs. Compared to non-methylated miR-21-5p, methylated miR-21-5p is more resistant to digestion by 3′→5′ exoribonuclease polyribonucleotide nucleotidyltransferase 1 (PNPT1) and has higher affinity to Argonaute-2, which may contribute to its higher stability and stronger inhibition on programmed cell death protein 4 (PDCD4) translation, respectively. Our findings reveal HENMT1-mediated 3′-terminal 2′Ome of mammalian miRNAs and highlight its role in enhancing miRNA’s stability and function.
The Party Abroad: A New Modus Operandi for Political Parties
Authors: Rashkova Ekaterina R 
Published: June 2020

Abstract
In an era where millions of people live elsewhere than their country of birth and many hold multiple nationalities, the questions of who and how represents these people becomes imperative. The traditional manner of representation is through political parties, yet the form in which parties have historically existed is within state bounds. Throughout time, we have witnessed the transition from cadre to cartel parties and through them the changing role of the political party. This article argues that with the vast expansion of the movement of people around the world, which has been influenced by the enlargement of the European Union, by globalisation, migration and most recently by the refugee crisis, political parties are reshaping their structures both domestically and internationally, and we are witnessing the development of a ‘new modus operandi’ of political parties—the party abroad. The party abroad is viewed as a natural evolvement of the functions of domestic political parties in their response to a changing civil society and changing competitive space. The article provides a theory of the party abroad, it discusses how it relates to previous models of political parties and offers a framework based on which we can study it.
Globalisation and the Movement of People: What It Means for Party Politics? An Introduction
Authors: Rashkova Ekaterina R , Van Der Staak Sam 
Published: June 2020

AbstractLiving in a globalised world, with its inherent easier movement of people between nations, imposes new challenges for representative democracy and for party politics specifically. Political parties have traditionally operated at a domestic level, yet, with the large number of people moving around the globe, this is now changing. This special section, deriving from a workshop on the topic, is one of the first attempts to systematically address this issue. It offers a theoretical framework and five empirical studies on the party abroad. The collection provides evidence of varied levels of existence of the party abroad in different contexts. It illustrates that the party abroad as a new modus operandi for parties that exist in all corners of the world; yet, it is most distinctly developed where the electoral stimuli and the type and size of the diaspora group give strategic incentive to political parties to do so.
Can the personalized medicine approach contribute in controlling tuberculosis in general and India in particular?
Authors: Khan Nikhat , Das Aparup 
Published: June 2020

Abstract
Poor drug compliance and drug-resistant Mycobacterium tuberculosis are the two principal obstacles in controlling tuberculosis (TB) in endemic regions including India, which has contributed the most to global TB burden. We argue here that a personalized medicine approach, to start with the N-acetyl transferase-2–isoniazid (NAT2–INH) model, could be a step forward in dealing with both these limitations in controlling TB in India.
The Wellbeing of UK Police: A Study of Recorded Absences from Work of UK Police Employees Due to Psychological Illness and Stress Using Freedom of Information Act Data
Authors: Cartwright Ashley , Roach Jason 
Published: June 2020

AbstractPolicing is undoubtedly a dangerous occupation whereby officers are routinely exposed to dangerous and potentially traumatic events, such as attending road traffic collisions, informing people of the death of a loved one, and ensuring public safety at football matches. Frontline policing is of course not the only place whereby constant exposure to dangerous and distressing incidents can increase the risk of police employees developing emotional and psychological complaints that have serious effects on their ‘wellbeing’, with previous research identifying specific policing areas such as homicide investigation as likely to have negative effects on those doing the investigating. Although to date, research has focused on the wellbeing effects of ‘routine policing’, criminal investigation, and specific events, as yet little is known about the effect on UK police employees wellbeing of ‘doing the job’ in terms of the number of days recorded as absent due to psychological illness, trauma, and stress. This study seeks to redress this gap by analysing sickness absence data recorded for 20 UK Police services for the past 10 years, obtained under the Freedom of Information (FOI) Act. The data set represents some 57% of UK police personnel, and findings suggest that police employee absence due to psychological ill health, trauma, and stress had nearly doubled in the past 10 years to an absence rate of 8.82%. Furthermore, this study found that 39% of those who take a first leave of absence due to mental ill health go on to take further absences from work.
Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank
Authors: Raisi-Estabragh Zahra , McCracken Celeste , Bethell Mae S , Cooper Jackie , Cooper Cyrus , Caulfield Mark J , Munroe Patricia B , Harvey Nicholas C , Petersen Steffen E 
Published: June 2020

Abstract

Background
We examined whether the greater severity of coronavirus disease 2019 (COVID-19) amongst men and Black, Asian and Minority Ethnic (BAME) individuals is explained by cardiometabolic, socio-economic or behavioural factors.

Methods
We studied 4510 UK Biobank participants tested for COVID-19 (positive, n = 1326). Multivariate logistic regression models including age, sex and ethnicity were used to test whether addition of (1) cardiometabolic factors [diabetes, hypertension, high cholesterol, prior myocardial infarction, smoking and body mass index (BMI)]; (2) 25(OH)-vitamin D; (3) poor diet; (4) Townsend deprivation score; (5) housing (home type, overcrowding) or (6) behavioural factors (sociability, risk taking) attenuated sex/ethnicity associations with COVID-19 status.

Results
There was over-representation of men and BAME ethnicities in the COVID-19 positive group. BAME individuals had, on average, poorer cardiometabolic profile, lower 25(OH)-vitamin D, greater material deprivation, and were more likely to live in larger households and in flats/apartments. Male sex, BAME ethnicity, higher BMI, higher Townsend deprivation score and household overcrowding were independently associated with significantly greater odds of COVID-19. The pattern of association was consistent for men and women; cardiometabolic, socio-demographic and behavioural factors did not attenuate sex/ethnicity associations.

Conclusions
In this study, sex and ethnicity differential pattern of COVID-19 was not adequately explained by variations in cardiometabolic factors, 25(OH)-vitamin D levels or socio-economic factors. Factors which underlie ethnic differences in COVID-19 may not be easily captured, and so investigation of alternative biological and genetic susceptibilities as well as more comprehensive assessment of the complex economic, social and behavioural differences should be prioritised.
Evaluating Firm-Level Expected-Return Proxies: Implications for Estimating Treatment Effects
Authors: Lee Charles M C , So Eric C , Wang Charles C Y 
Published: June 2020

Abstract
We introduce a parsimonious framework for choosing among alternative expected-return proxies (ERPs) when estimating treatment effects. By comparing ERPs’ measurement error variances in the cross-section and in the time series, we provide new evidence on the relative performance of firm-level ERPs nominated by recent studies. Generally, “implied-costs-of-capital” metrics perform best in the time series, whereas “characteristic-based” proxies perform best in the cross-section. Factor-based ERPs, even the latest renditions, perform poorly. We revisit four prior studies that use ex ante ERPs and illustrate how this framework can potentially alter either the sign or the magnitude of prior inferences.
Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000–2016
Authors: Zeng Chao , Zhang Weiya , Doherty Michael , Persson Monica S M , Mallen Christian , Swain Subhashisa , Li Xiaoxiao , Wei Jie , Lei Guanghua , Zhang Yuqing 
Published: June 2020

Abstract

Objectives
To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA.

Methods
Patients consulting with incident clinical OA between 2000–2016 were identified within The Health Improvement Network in the United Kingdom (UK) general practice. Excluded were patients who had history of cancer or were prescribed the analgesics of interest within 6 months before diagnosis of OA. Initial analgesic prescription included oral non-selective NSAID, oral selective cyclooxygenase-2 inhibitor, topical NSAID, paracetamol, topical salicylate or oral/transdermal opioid within 1 month after OA diagnosis.

Results
∼44% of patients with incident OA (n = 125 696) were prescribed one of these analgesics. Incidence of oral NSAID prescriptions decreased whereas other analgesic prescriptions, including oral opioid prescriptions, increased (all P-for-trend &lt; 0.001). Patients with a history of gastrointestinal disease were more likely to receive topical NSAIDs, paracetamol or oral/transdermal opioids. Only 38% of patients with history of gastrointestinal disease and 21% of patients without it had co-prescription of gastroprotective agent with oral NSAIDs. Oral/transdermal opioid prescription was higher among the elderly (≥65 years), women, obesity, current smoker, and patients with gastrointestinal, cardiovascular or chronic kidney disease. Prescription of oral opioids increased with social deprivation (P-for-trend &lt; 0.05) and was highest in Scotland, whereas transdermal opioid prescription was highest in Northern Ireland (all P-for-homogeneity-test &lt; 0.05).

Conclusion
The initial prescription pattern of analgesics for OA has changed over time in the UK. Co-prescription of gastroprotective agents with oral NSAIDs remains suboptimal, even among those with prior gastrointestinal disease.
Phylogenomics of Monitor Lizards and the Role of Competition in Dictating Body Size Disparity
Authors: Brennan Ian G , Lemmon Alan R , Lemmon Emily Moriarty , Portik Daniel M , Weijola Valter , Welton Luke , Donnellan Stephen C , Keogh J Scott 
Published: June 2020

AbstractOrganismal interactions drive the accumulation of diversity by influencing species ranges, morphology, and behavior. Interactions vary from agonistic to cooperative and should result in predictable patterns in trait and range evolution. However, despite a conceptual understanding of these processes, they have been difficult to model, particularly on macroevolutionary timescales and across broad geographic spaces. Here, we investigate the influence of biotic interactions on trait evolution and community assembly in monitor lizards (Varanus). Monitors are an iconic radiation with a cosmopolitan distribution and the greatest size disparity of any living terrestrial vertebrate genus. Between the colossal Komodo dragon Varanus komodoensis and the smallest Australian dwarf goannas, Varanus length and mass vary by multiple orders of magnitude. To test the hypothesis that size variation in this genus was driven by character displacement, we extended existing phylogenetic comparative methods which consider lineage interactions to account for dynamic biogeographic history and apply these methods to Australian monitors and marsupial predators. Incorporating both exon-capture molecular and morphological data sets we use a combined evidence approach to estimate the relationships among living and extinct varaniform lizards. Our results suggest that communities of Australian Varanus show high functional diversity as a result of continent-wide interspecific competition among monitors but not with faunivorous marsupials. We demonstrate that patterns of trait evolution resulting from character displacement on continental scales are recoverable from comparative data and highlight that these macroevolutionary patterns may develop in parallel across widely distributed sympatric groups.[Character displacement; comparative methods; phylogenetics; trait evolution; Varanus.]
Lessons learned from an under-reported mumps epidemic among Rohingya refugees in Cox's Bazar District, Bangladesh
Authors: Mair Luke , Relan Pryanka , Hamilton David Oliver , Al-Noman Abdullah , O'Dempsey Timothy 
Published: June 2020

Abstract

Background
In 2018, a large mumps epidemic coincided with an outbreak of diphtheria in refugee camps established in Bangladesh for the Rohingya people. These refugees did not receive a mumps-containing vaccine.

Methods
Cases of mumps were reported to the WHO's Early Warning, Alert and Response System (EWARS) during the Rohingya refugee crisis. The authors present amalgamated epidemiological data of a major, previously under-reported, mumps epidemic.

Results
In total, 19 215 mumps cases across a total of 218 facilities were reported to EWARS during 2018. The attack rate was 2.1% of the whole population. Of these cases, 7687 (40%) were in children aged &lt;5 y. Mumps was more commonly seen among males than females.

Conclusion
Detailed reporting of outbreaks of all vaccine-preventable diseases is essential to ensure appropriate vaccination decisions can be made in future humanitarian crises.
An open-circuit fault-diagnosis method for inverters based on phase current
Authors: Cheng Shu , Zhao Jundong , Chen Chunyang , Li Kaidi , Wu Xun , Yu Tianjian , Yu Yongsheng 
Published: June 2020

Abstract
The inverter is an indispensable part of a power electronics system. Its safety and stability are important indicators for evaluating the reliability of the system. Inverter faults are usually caused by operating faults in the switch elements. This paper therefore proposes a non-intrusive fault-diagnosis method for open-circuit faults in inverter semiconductor power switches. This method requires only a current signal. It is simple and economical. Faults can be diagnosed quickly using the proposed algorithm. First, the phase current waveforms before and after the open-circuit fault are analysed based on the mathematical model. Then, based on the analysis of the phase currents, the fault features are extracted and the fault is located using the proposed integration algorithm. Finally, the effectiveness and reliability of the proposed fault-diagnosis method are verified using a hardware-in-the-loop experiment.
Exercise Addiction Prevalence and Correlates in the Absence of Eating Disorder Symptomology: A Systematic Review and Meta-analysis
Authors: Trott Mike , Jackson Sarah E. , Firth Joseph , Fisher Abigail , Johnstone James , Mistry Amit , Stubbs Brendon , Smith Lee 
Published: June 2020

Background:Exercise addiction (EA) can be debilitating and can be a symptom of an eating disorder. To date, the prevalence rates of EA without indicated eating disorders in the general population and associated correlates remain unreported.Methods:Two authors searched major databases from inception to 31/12/2018 to identify studies investigating the prevalence of EA in any population without indicated eating disorders. We conducted a random effects meta-analysis to report (i) prevalence rates of EA using the exercise addiction inventory and exercise dependence scale and compare sub-populations, (ii) compare methods of EA measurement and explore heterogeneity, and (iii) report on correlates.Results:A total of 13 studies including 3635 people were included. The prevalence of EA among general exercisers was 8.1% (95% CI 1.5%–34.2%), amateur competitive athletes was 5.0% (95% CI 1.3%–17.3%), and university students was 5.5% (95% CI 1.4–19.1%%). Overall prevalence rates varied depending on the EA measurement tool. EA subjects were more likely to have lower levels of overall wellbeing (only in amateur competitive athletes), higher anxiety levels, and have greater frontal brain activity.Conclusions:EA is prevalent in the absence of indicated eating disorders across populations but varies depending on measurement tool. Further research is needed to explore EA without indicated eating disorders in different populations using homogenous measurement tools, further determine psychological correlates, and examine which measures of EA without indicated eating disorders predict poor health outcomes.
The Effect of Atropine on Trigeminocardiac Reflex-induced Hemodynamic Changes During Therapeutic Compression of the Trigeminal Ganglion
Authors: Wang Chang-Ming , Guan Zhan-Ying , Zhao Ping , Huang Hai-Tao , Zhang Jing , Li Yan-Feng , Ma Yi 
Published: June 2020

Background:
Percutaneous compression of the trigeminal ganglion (PCTG) can induce significant hemodynamic perturbations secondary to the trigeminocardiac reflex (TCR). The aim of this study was to investigate the effect of atropine pretreatment on hemodynamic responses during PCTG for trigeminal neuralgia.

Materials and Methods:
A total of 120 patients who received PCTG were randomly assigned to control and atropine groups that were pretreated with saline (n=60) and atropine 0.004 mg/kg intravenously (n=60), respectively. Heart rate (HR) and mean arterial pressure (MAP) were measured at 9 timepoints from before induction of anesthesia until the end of the PCTG procedure; the incidence of TCR was also observed.

Results:
HR was higher in the atropine compared with control group from the time of skin puncture with the PCTG needle until after the procedure was completed (P<0.05). MAP was also higher in the atropine compared with control group, but only at entry of the needle into the foramen ovale until 1 minute after trigeminal ganglion compression (P<0.05). HR was reduced in both groups during entry of the needle into the foramen ovale and during ganglion compression, but less so in the atropine compared with the control group (P<0.05). MAP increased during PCTG compared with baseline in both groups, but with a larger increase in the atropine group (P<0.05). Two and 52 cases in the control group, and 6 and 1 cases in the atropine group, exhibited a TCR during entry of the needle into the foramen ovale and at ganglion compression, respectively (P<0.05).

Conclusion:
Pretreatment with atropine was effective in most patients at minimizing abrupt reduction in HR during PCTG.
Impacts of Primary Care Physician System on Healthcare Utilization and Antibiotic Prescription: Difference-in-Differences and Causal Mediation Analyses
Authors: Okubo Yusuke , Michihata Nobuaki , Uda Kazuhiro , Kinoshita Noriko , Horikoshi Yuho , Miyairi Isao 
Published: June 2020

Background:
The overutilization of healthcare and overuse/misuse of antibiotics in Japan are responsible for the increase in healthcare expenditure and the development of antimicrobial resistance. The Japanese government started paying incentives to medical facilities for primary care physician registrations, but the impact of this new policy is still unclear.

Methods:
We conducted a retrospective cohort study for all pediatric outpatients from April 2015 to December 2016 in Japan, targeting 1.4 million children under 2 years of age. We investigated the effects of primary care physician registration on physician visits, total antibiotic use and admission rates using difference-in-differences (DID) and causal mediation analyses.

Results:
DID analyses showed that primary care registration policy contributed to increases in total physician visits, total and broad-spectrum antibiotic use and radiologic study utilization, but reduced out-of-hour visits and did not affect hospitalization rates. Similar results were obtained when we adjusted for and matched on potential confounders. Causal mediation analyses found that the greatest pathway was controlled by direct effects of 53.2 DOTs per 1000 person-months (95% CI: 29.1–77.2), indicating that the effect of new health policy that did not mediate increased outpatient visits mostly contributed to the excess use of antibiotics.

Conclusions:
The health policy further increased antibiotic use. On April 2018, a new health policy of paying incentives for not prescribing antibiotics to children with respiratory infection or gastroenteritis was initiated. Further studies are needed whether this new health policy can mitigate the overutilization of healthcare and antibiotic use.