bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling of SDG’s Achievement in East Java Using Bi-responses Nonparametric Regression with Mixed Estimator Spline Truncated and Kernel
Authors: Dewanti Paramita , Nyoman Budiantara I , Rumiati Agnes Tuti 
Published: June 2020

Abstract
The Government of Indonesia has grouped 17 objectives of SDG’s into 4 pillars, among others: social pillars, economic pillars, the pillars of environmental development and the pillars of legal development and Governance. Some strategic indicators are used to know the achievement of SDG’S especially achievement in social and economic pillars such as the Human Development Index (HDI) and Gini Ratio. There are several variables affecting then. A method used to model the effects of its variables is regression analysis. The results of the initial exploration through the scatter plot shows a pattern that changes and disconnects at a certain point for a variable IPM with a variable that is allegedly influencing it. With a scatter plot, it can be found that between the Gini ratio variables with some of its predictive variables, does not have a specific pattern. Bi-responses nonparametric regression is an analysis that appropriates with that case. Bi-responses nonparametric regression analysis is a type of nonparametric regression analysis used when the pattern between two response variables and some of the predictor variables is unknown or if there is no prior information regarding the pattern of them. Most of researchers use bi-responses nonparametric regression approached by spline truncated, kernel and etc. Most of the research, use kernel and spline truncated because of their advantages such as: have a good capability to develop model from unknown pattern data and have a good visual representation. The first aim of this paper is obtaining the estimator of mixed estimator spline truncated and kernel in bi-responses nonparametric regression with weighted least square. The second aim is gaining a best model to explain the relationship indicators of SDG’s achievement with some variables affecting them. To obtain the best model, it is necessary to select the optimal of knots point and bandwidth parameters using a smallest Generalized Cross Validation (GCV).
A photoactivatable antibody–Chlorin e6 conjugate enabling singlet oxygen production for tumor-targeting photodynamic therapy
Authors: Pan Qi , Li Kaixuan , Cheng Xiaoyi , Chen Lin , Yu Qi , Fan HengXin , Zheng Liang , Yang Zihua , Ni Feng 
Published: June 2020

Abstract
Photodynamic therapy is a new technology for disease diagnosis and treatment in modern medical clinics. The main advantages of photodynamic therapy are low toxicity and side effects, a wide range of applications, no drug resistance, and no obvious trauma in the treatment process. However, to achieve effective photodynamic therapy, new photosensitizer carriers need to be constructed, which can selectively deliver photosensitizers into tumor tissues. In this work, a photoactivatable antibody–Chlorin e6 conjugate with a dual-function to target tumor tissue and realize cancer photodynamic therapy is constructed. Both in vitro and in vivo experiments indicate that the antibody–Chlorin e6 conjugate has the ability to target tumors rapidly and efficiently, and has the ability to generate reactive oxygen species and kill tumor cells. Overall, this photoactivable antibody–Chlorin e6 conjugate may provide a promising strategy to address the current challenges of cancer photodynamic therapy.
Photocatalytic efficiency of brilliant green dye on ZnO loaded on cotton stalk activated carbon
Authors: Nithya R , Ragupathy S , Sakthi D , Arun V , Kannadasan N 
Published: June 2020

Abstract
In this study, ZnO loaded on cotton stalk activated carbon (ZnO/CSAC) has been successfully synthesized by the chemical precipitation method. XRD patterns showed that ZnO/CSAC have two phases are hexagonal wurtizite and amorphous structures. The average particle size is reduced (12.4 nm) upon loading CSAC than the ZnO NPs. The band gap value is decreased (2.50 eV) upon loading on CSAC compared to ZnO NPs. The functional groups identify using by FT-IR spectrum. FE-SEM images a pure ZnO revealed a 15–40 nm spherical structure and 10–35 nm large agglomerations spherical structure for ZnO/CSAC and then, EDAX spectrum affirmed the formation of ZnO/CSAC. BET surface area and pore volume of the 22.18 m2 g−1 and 0.210 cm3 g−1 for the ZnO NPs and make it increased surface area and pore volume due to the adding CSAC to 263.18 m2 g−1 and 0.306 cm3 g−1. The photocatalytic degradation efficiency of brilliant green (BG) dye and results shows that ZnO/CSAC sample improves photocatalytic activity than the ZnO NPs. Amidst all; ZnO/CSAC showed the maximum degradation the efficiency (90.26%) than the ZnO. These results show that the ZnO/CSAC sample is due to the synergistic effect between ZnO (photocatalysts) and CSAC (adsorption), its also possible mechanism and pseudo-first-order model are used to analysis the kinetics.
Distributed mixed signal demultiplexer for electrocorticography electrodes
Authors: Marcoleta Juan Pablo , Nogueira Waldo , Doll Theodor 
Published: June 2020

Abstract
This work presents a novel architecture, exemplified for electrophysiological applications like ECoG that can be used to detect Epilepsy. The new ECoG is based on a mixed analog-digital architecture (Pulse Amplitude Modulation PAM), that allows the use of thousands of electrodes for recording. Whilst the increased number of electrodes helps to refine the spatial resolution of the medical application, the transmission of the signals from the electrodes to an external analysing device appears to be a bottleneck. To overcoming this, our work presents a hardware architecture and corresponding protocol for a mixed architecture that improves the information density between channels and their signal-to-noise ratio. This is shown by the correlation between the input and the transmitted signals in comparison to a classical digital transmission (Pulse Code Modulation PCM) system. We show in this work that it is possible to transmit the signals of 10 channels with a analog-digital architecture with the same quality of a full digital architecture.
Origins
Authors: Greenhouse Linda 
Published: June 2020

Abstract
How does the Supreme Court in the early twenty-first century differ with regard to the intentions of the Framers in 1787? “Origins” looks at the Court’s development from a diffuse institution, with judges based at home or traveling around the country, to a secure base in the Capitol. Ever since Article III announced a national court with the authority to decide cases “arising under” the country’s Constitution, the role of the Supreme Court has been a matter of dispute. From the beginning, the Court has filled in the blanks contained in Article III. How has the modern Court become able to define and exercise its own power?
The chief justice
Authors: Greenhouse Linda 
Published: June 2020

Abstract
The chief justice is not mentioned in the judicial article of the Constitution (Article III), but “The chief justice” demonstrates how the role has grown in importance over time. It is a multifaceted role, like that of a chief executive of a company. A traditional legal background is not necessarily the best preparation. Some chief justices believed that casting one of the nine votes in a case is still one of their most useful functions. It was a chief justice, William Howard Taft, who decided that the Supreme Court’s caseload should be decided on a discretionary basis, putting the Court in a position to dictate America’s legal agenda.
Implementation of a Standardized Prenatal Testing Protocol in an Integrated, Multihospital Health System
Authors: Sapatnekar Suneeti , Lu Wen , Bakdash Suzanne , Quraishy NurJehan 
Published: June 2020

AbstractObjectivesWhen our institution grew into an integrated multihospital health system, we were faced with the need to standardize laboratory processes, including blood bank processes, across all locations. The purpose of this article is to describe our experience of standardizing the protocols for prenatal testing.MethodsFor each hospital in the system, we established service tiers to define tests offered on site or referred to another location. For each prenatal test, we examined the related processes for ways to improve uniformity, efficiency, and reliability. Throughout this process of standardization, we collaborated with the clinical services to gain concurrence on the interpretation and reporting of results.ResultsWe created and implemented a uniform protocol for testing prenatal patients. The protocol standardized the definition of critical titer, instituted criteria to identify passively acquired anti-D, and established a process for the follow-up of women with inconsistent serologic results on Rh(D) typing.ConclusionsClose collaboration with the clinical services ensured that our testing protocol is aligned with the needs of the integrated obstetrics service in the health system. The approach described in this article may provide a plan outline for pathologists facing similar challenges at other integrated health systems.
Life After Death
Authors: Gaur Kavita , Sakhuja Puja , Majumdar Kaushik , Thakral Divya Arora 
Published: June 2020

Abstract

Objectives
To test the performance characteristics of 69 primary immunohistochemistry antibodies after expiration and compare with fresh primary antibodies wherever possible.

Methods
A total of 69 expired primary antibodies were evaluated for specificity, background staining, and intensity. An optimal staining result corresponded to a semiquantitatively scored 2+ or 3+ intensity, with intact specificity devoid of moderate or strong background staining. Any deviation from a normal staining pattern was also considered to be a suboptimal result.

Results
Nearly half of the antibodies studied showed an optimally positive staining result after expiration (34/69, 49.2%). Overall, 10.1% (7/69) of antibodies could be compared with fresh primary antibodies of the same clone with equivalent results. Eight of 69 (11.6%) expired antibodies showed splotchy or granular staining.

Conclusions
Evidence from this study and previous work point to maintained functionality of a fair number of primary immunohistochemical antibodies after expiration. Decisions about the use of such reagents should be guided by a thorough assessment of functionality by the pathologist rather than a manufacturer-specified deadline. Quality maintenance should imply a sensible balance between histopathologic performance and economics.
The Impact of the Philtrum on Facial Attractiveness, Perioral Proportions, and Perceptions of Facial Aging
Authors: Nunes Diogo , Bran Gregor 
Published: June 2020

Abstract

Background
Lip enhancement continues to be one of the most popular facial procedures. State-of-the-art lip enhancement involves sculpting of perilabial soft tissue, in particular, the philtrum, but it is unclear how patients perceive their philtral contours.

Objectives
The aim of this study was to test the impact of the philtrum on attractiveness, and on the perception of facial proportions and age.

Methods
Respondents (1100, including 50 aesthetic specialists) were presented with 2 sets of identical portraits, 1 set of a young Caucasian female and 1 set of an aged Caucasian female, with 1 portrait in each set having an upper lip lacking any philtral contours. The respondents were asked to choose which upper lip was more attractive, appeared longer, and looked older. Rankings were analyzed according to population demographics.

Results
Overall, most respondents considered the young face (84%) and the aged face (68%) with philtral contours to be more attractive. Moreover, the majority of respondents (81%) considered the upper lip of the young face without a philtrum to appear longer in a craniocaudal orientation (67% for the aged image), and 67% of respondents described the image of the young woman with no philtral definition as appearing older (55% for the aged face with no philtrum).

Conclusions
This study confirms the authors’ hypothesis that the existence of philtral contours exerts a significant impact on perioral attractiveness, and that its absence can be related to a longer appearance of the upper lip as well as an older facial appearance.
The Role of the Social Worker at the End of Life: Paving the Way in an Academic Hospital Quality Improvement Initiative
Authors: Stilos Kalliopi (Kalli) , Takahashi Danielle , Nolen Amy Eleanor 
Published: June 2020

Abstract
The end-of-life (EOL) experience of patients dying in acute care has been highlighted as an area for quality improvement. Delivering comprehensive care to these patients involves addressing physical symptoms and psychosocial concerns. The social work role offers a range of interventions to address the common domains of EOL care. We report on results of an EOL survey evaluating satisfaction with social work interventions for imminently dying patients in acute care. This article is the first phase towards gaining an understanding of the contributions of the social worker in supporting dying patients and their families within our organisation.
High prevalence of carpal tunnel syndrome in individuals with rare nerve growth factor-beta mutation
Authors: Ridderström Mikael , Svantesson Mats , Thorell Oumie , Magounakis Theofilos , Minde Jan , Olausson Håkan , Nagi Saad S 
Published: June 2020

Abstract
In Sweden, a large family with a point mutation in the nerve growth factor-beta gene has previously been identified. The carriers of this mutation have reduced small-fibre density and selective deficits in deep pain and temperature modalities. The clinical findings in this population are described as hereditary sensory and autonomic neuropathy type V. The purpose of the current study was to investigate the prevalence of carpal tunnel syndrome in hereditary sensory and autonomic neuropathy type V based on clinical examinations and electrophysiological measurements. Furthermore, the cross-sectional area of the median nerve at the carpal tunnel inlet was measured with ultrasonography. Out of 52 known individuals heterozygous for the nerve growth factor-beta mutation in Sweden, 23 participated in the current study (12 males, 11 females; mean age 55 years; range 25–86 years). All participants answered a health questionnaire and underwent clinical examination followed by median nerve conduction study in a case–control design, and measurement of the nerve cross-sectional area with ultrasonography. The diagnosis of carpal tunnel syndrome was made based on consensus criteria using patient history and nerve conduction study. The prevalence of carpal tunnel syndrome in the hereditary sensory and autonomic neuropathy group was 35% or 52% depending on whether those individuals who had classic symptoms of carpal tunnel syndrome but negative nerve conduction studies were included or not. Those who had a high likelihood of carpal tunnel syndrome based on classic/probable patient history with positive nerve conduction study had a significantly larger median nerve cross-sectional area than those who had an unlikely patient history with negative nerve conduction study. The prevalence of carpal tunnel syndrome was 10–25 times higher in individuals heterozygous for the nerve growth factor-beta mutation than the general Swedish population. Further studies are needed to better understand the underlying pathophysiological mechanisms.
Extravascular Dermal Trypanosomes in Suspected and Confirmed Cases of gambiense Human African Trypanosomiasis
Authors: Camara Mariame , Soumah Alseny M’mah , Ilboudo Hamidou , Travaillé Christelle , Clucas Caroline , Cooper Anneli , Kuispond Swar Nono-Raymond , Camara Oumou , Sadissou Ibrahim , Calvo Alvarez Estefania , Crouzols Aline , Bart Jean-Mathieu , Jamonneau Vincent , Camara Mamadou , MacLeod Annette , Bucheton Bruno , Rotureau Brice 
Published: June 2020

Abstract

Background
The diagnosis of gambiense human African trypanosomiasis (gHAT) typically involves 2 steps: a serological screen, followed by the detection of living trypanosome parasites in the blood or lymph node aspirate. Live parasites can, however, remain undetected in some seropositive individuals, who, we hypothesize, are infected with Trypanosoma brucei gambiense parasites in their extravascular dermis.

Methods
To test this hypothesis, we conducted a prospective observational cohort study in the gHAT focus of Forecariah, Republic of Guinea. Of the 5417 subjects serologically screened for gHAT, 66 were enrolled into our study and underwent a dermatological examination. At enrollment, 11 seronegative, 8 unconfirmed seropositive, and 18 confirmed seropositive individuals had blood samples and skin biopsies taken and examined for trypanosomes by molecular and immunohistological methods.

Results
In seropositive individuals, dermatological symptoms were significantly more frequent, relative to seronegative controls. T.b. gambiense parasites were present in the blood of all confirmed cases (n = 18) but not in unconfirmed seropositive individuals (n = 8). However, T. brucei parasites were detected in the extravascular dermis of all unconfirmed seropositive individuals and all confirmed cases. Skin biopsies of all treated cases and most seropositive untreated individuals progressively became negative for trypanosomes 6 and 20 months later.

Conclusions
Our results highlight the skin as a potential reservoir for African trypanosomes, with implications for our understanding of this disease’s epidemiology in the context of its planned elimination and underlining the skin as a novel target for gHAT diagnostics.
OPTIK: a database for understanding catchment areas to guide mobilization of cancer center assets
Authors: Mudaranthakam Dinesh Pal , Harlan-Williams Lisa M , Jensen Roy A , Kuo Hanluen , Garimella Vandita , Chen Ronald C , Mayo Matthew S , Krebill Hope 
Published: June 2020

AbstractAn increasingly diversified demographic landscape in rural and urban America warrants the attention of The University of Kansas Cancer Center (KU Cancer Center) researchers, clinicians, outreach staff and administrators as the institution assesses ways to reach its expansive, bi-state catchment area. Within the counties of the KU Cancer Center catchment area, patient level and public health data are available and categorized by varying geographic regional boundaries. Multiple data sources and different data collection processes complicate summarizing catchment area data. A curated data warehouse that retrieves and structures the data, with a common denominator, can support meaningful use of the data in a standard and consistent format. The KU Cancer Center built a data warehouse to Organize and Prioritize Trends to Inform KU Cancer Center (OPTIK), which functions to streamline the process of synthesizing data regarding Kansas and Missouri demographics, cancer risk factors and incidence and mortality rates. OPTIK standardizes these diverse data sources to enable analyses of the cancer burden at local, regional and national levels while upholding a strict standard of patient privacy. The OPTIK database enables researchers to use available data and create heat maps and other visualizations to aid in funding proposals, presentations and research activities. Furthermore, using knowledge provided by OPTIK, the KU Cancer Center is able to prioritize action items for research and outreach and more effectively communicate the impact of those efforts.
Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial
Authors: Makkar Raj R , Kereiakes Dean J , Aguirre Frank , Kowalchuk Glenn , Chakravarty Tarun , Malliaras Konstantinos , Francis Gary S , Povsic Thomas J , Schatz Richard , Traverse Jay H , Pogoda Janice M , Smith Rachel R , Marbán Linda , Ascheim Deborah D , Ostovaneh Mohammad R , Lima João A C , DeMaria Anthony , Marbán Eduardo , Henry Timothy D 
Published: June 2020

Abstract

Aims
Cardiosphere-derived cells (CDCs) are cardiac progenitor cells that exhibit disease-modifying bioactivity in various models of cardiomyopathy and in previous clinical studies of acute myocardial infarction (MI), dilated cardiomyopathy, and Duchenne muscular dystrophy. The aim of the study was to assess the safety and efficacy of intracoronary administration of allogeneic CDCs in the multicentre, randomized, double-blinded, placebo-controlled, intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR) trial.

Methods and results
We enrolled patients 4 weeks to 12 months after MI, with left ventricular ejection fraction (LVEF) ≤45% and LV scar size ≥15% of LV mass by magnetic resonance imaging (MRI). A pre-specified interim analysis was performed when 6-month MRI data were available. The trial was subsequently stopped due to the low probability of detecting a significant treatment effect of CDCs based on the primary endpoint. Patients were randomly allocated in a 2:1 ratio to receive CDCs or placebo in the infarct-related artery by stop-flow technique. The primary safety endpoint was the occurrence, during 1-month post-intracoronary infusion, of acute myocarditis attributable to allogeneic CDCs, ventricular tachycardia- or ventricular fibrillation-related death, sudden unexpected death, or a major adverse cardiac event (death or hospitalization for heart failure or non-fatal MI or need for left ventricular assist device or heart transplant). The primary efficacy endpoint was the relative percentage change in infarct size at 12 months post-infusion as assessed by contrast-enhanced cardiac MRI. We randomly allocated 142 eligible patients of whom 134 were treated (90 to the CDC group and 44 to the placebo group). The mean baseline LVEF was 40% and the mean scar size was 22% of LV mass. No primary safety endpoint events occurred. There was no difference in the percentage change from baseline in scar size (P = 0.51) between CDCs and placebo groups at 6 months. Compared with placebo, there were significant reductions in LV end-diastolic volume (P = 0.02), LV end-systolic volume (P = 0.02), and N-terminal pro b-type natriuretic peptide (NT-proBNP) (P = 0.02) at 6 months in CDC-treated patients.

Conclusion
Intracoronary infusion of allogeneic CDCs in patients with post-MI LV dysfunction was safe but did not reduce scar size relative to placebo at 6 months. Nevertheless, the reductions in LV volumes and NT-proBNP reveal disease-modifying bioactivity of CDCs.

Trial registration
Clinicaltrials.gov identifier: NCT01458405.