bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision of a Clinical Metabolomics Profiling Platform for Use in the Identification of Inborn Errors of Metabolism
Authors: Ford Lisa , Kennedy Adam D , Goodman Kelli D , Pappan Kirk L , Evans Anne M , Miller Luke A D , Wulff Jacob E , Wiggs Bobby R , Lennon John J , Elsea Sarah , Toal Douglas R 
Published: January 2020

Abstract

Background
The application of whole-exome sequencing for the diagnosis of genetic disease has paved the way for systems-based approaches in the clinical laboratory. Here, we describe a clinical metabolomics method for the screening of metabolic diseases through the analysis of a multi-pronged mass spectrometry platform. By simultaneously measuring hundreds of metabolites in a single sample, clinical metabolomics offers a comprehensive approach to identify metabolic perturbations across multiple biochemical pathways.

Methods
We conducted a single- and multi-day precision study on hundreds of metabolites in human plasma on 4, multi-arm, high-throughput metabolomics platforms.

Results
The average laboratory coefficient of variation (CV) on the 4 platforms was between 9.3 and 11.5% (median, 6.5–8.4%), average inter-assay CV on the 4 platforms ranged from 9.9 to 12.6% (median, 7.0–8.3%) and average intra-assay CV on the 4 platforms ranged from 5.7 to 6.9% (median, 3.5–4.4%). In relation to patient sample testing, the precision of multiple biomarkers associated with IEM disorders showed CVs that ranged from 0.2 to 11.0% across 4 analytical batches.

Conclusions
This evaluation describes single and multi-day precision across 4 identical metabolomics platforms, comprised each of 4 independent method arms, and reproducibility of the method for the measurement of key IEM metabolites in patient samples across multiple analytical batches, providing evidence that the method is robust and reproducible for the screening of patients with inborn errors of metabolism.
Utilization of Patient Navigators in Breast Imaging Facilities Across the United States: A Survey of Breast Imaging Radiologists
Authors: Lee Amie Y , Plecha Donna , Woodard Genevieve A , Price Elissa R , Hayward Jessica H , Mark Sueanne , Joe Bonnie N 
Published: January 2020

Abstract

Objective
To assess the utilization of patient navigators at breast imaging facilities across the United States.

Methods
An online survey was distributed to physician members of the Society of Breast Imaging. Questions encompassed use of patient navigators in breast imaging including: presence and qualifications, roles in patient care, perceived benefits, and barriers. Data were analyzed to identify the overall prevalence of patient navigators, their responsibilities and qualifications, and the impact on breast imaging centers.

Results
Three-hundred and eighty-five board-certified radiologists practicing in the United States completed the survey. The most common practice types were private practice (52%; 201/385) and academic (29%; 110/385). The majority (67%; 256/385) employed navigators, and the most common qualification was a registered nurse (78%; 200/256). Navigators were used for a variety of patient communication and care coordination roles, most commonly to provide educational resources (86%; 219/256), assist patients with scheduling appointments (80%; 205/256), explain the biopsy process (76%;195/256), and communicate biopsy results (64%). Nearly all (99%; 254/256) respondents ranked patient navigators as valuable to extremely valuable in improving patient care and indicated they would recommend implementation of a patient navigation program to other breast imaging practices. The most common barrier to employing a navigator was the financial cost.

Conclusion
Patient navigators have been widely adopted in breast imaging practices across the United States, with two-thirds of respondents reporting use of a navigator. Although navigator roles varied by practice, nearly all radiologists utilizing patient navigators found that they positively impact patient care and would recommend them to other breast imaging practices.
On the application of compression-based metrics to identifying anomalous behaviour in web traffic
Authors: de la Torre-Abaitua Gonzalo , Lago-Fernández Luis F , Arroyo David 
Published: January 2020

AbstractIn cybersecurity, there is a call for adaptive, accurate and efficient procedures to identifying performance shortcomings and security breaches. The increasing complexity of both Internet services and traffic determines a scenario that in many cases impedes the proper deployment of intrusion detection and prevention systems. Although it is a common practice to monitor network and applications activity, there is not a general methodology to codify and interpret the recorded events. Moreover, this lack of methodology somehow erodes the possibility of diagnosing whether event detection and recording is adequately performed. As a result, there is an urge to construct general codification and classification procedures to be applied on any type of security event in any activity log. This work is focused on defining such a method using the so-called normalized compression distance (NCD). NCD is parameter-free and can be applied to determine the distance between events expressed using strings. As a first step in the concretion of a methodology for the integral interpretation of security events, this work is devoted to the characterization of web logs. On the grounds of the NCD, we propose an anomaly-based procedure for identifying web attacks from web logs. Given a web query as stored in a security log, a NCD-based feature vector is created and classified using a support vector machine. The method is tested using the CSIC-2010 data set, and the results are analyzed with respect to similar proposals.
Italian court orders Amazon not to sell luxury cosmetics subject to a selective distribution network
Authors: Giannino Michele 
Published: January 2020

Abstract
Case 50977/2018 Sisley Italia et al v Amazon Core Europe et al (Sisley v Amazon) (2019) District Court of Milan, Commercial Law Chamber, Decision of 28 March 2019
In upholding an application for an interlocutory injunction, the District Court of Milan ordered Amazon to refrain from marketing, selling, promoting or advertising on its Amazon Marketplace Sisley high - quality cosmetics. The court considered that offering luxury products alongside low-quality goods on the same Internet site: (i) is incompatible with the qualitative standards, which the members of the selective distribution system covering the said cosmetics have to respect; (ii) constitutes trade mark infringement as the existence of a lawful selective distribution network is a legitimate reason for the non-application of the exhaustion principle.
Diffusion kurtosis imaging and tumour microstructure for monitoring response to radiotherapy in human nasopharyngeal carcinoma xenografts
Authors: Zheng Xiang , Chen Yunbin , Zheng Dechun , Xiao Youping , Chen Jiayou , Pan Jianji , Chen Weibo 
Published: January 2020

Abstract

Objective
To investigate the correlations and feasibility of diffusion kurtosis imaging (DKI) parameters and tumour histopathology after radiotherapy in human nasopharyngeal carcinoma (NPC) xenografts on nude mice.

Materials and Methods
Seventy-two nude mice were used for the construction of CNE-1 (radio-insensitive) and CNE-2 (radio-sensitive) NPC xenograft models, followed by fraction irradiation at different doses of X-ray. The nude mice were randomly divided into six groups in each cell line models according to the dose of X-ray they have received and with six mice in each group. DKI scan was performed after radiation. DKI parameters, tumour histopathology and AQP-1 biomarkers were detected. One-way ANOVA and Pearson’s correlation analysis were used in statistical analysis.

Results
In CNE-1 and CNE-2 NPC xenografts, D values were increased (P &lt; 0.01 and P &lt; 0.001), while K values (P &lt; 0.01 and P &lt; 0.001) and tumour size (P &lt; 0.001 and P &lt; 0.001) were reduced during fraction irradiation. Additionally, cell density (CD) and AQP-1 expressions were decreased, and necrosis ratio (NR) was increased in CNE-2 xenografts after fraction irradiation (P &lt; 0.001). The changes in D values were negatively correlated with tumour size (r = −0.856, P &lt; 0.001), CD (r = −0.918, P &lt; 0.001), AQP-1 mRNA (r = −0.856, P &lt; 0.001) and protein (r = −0.381, P = 0.022) expressions while positively correlated with NR (r = 0.908, P &lt; 0.001) in CNE-2 xenografts. The changes in K values were positively correlated with tumour size (r = 0.964, P &lt; 0.001), CD (r = 0.888, P &lt; 0.001), AQP-1 mRNA (r = 0.955, P &lt; 0.001) and protein (r = 0.330, P = 0.049) expression levels while negatively correlated with NR (r = −0.930, P &lt; 0.001). However, in CNE-1 xenografts, there were no correlation between DKI parameters and the expression of AQP-1.

Conclusion
Changes in D and K parameters after fractional irradiation are closely related with NPC cellular and pathological characteristics, especially size reduction and necrosis induction. These parameters exhibit potential abilities of monitoring the response to fractional irradiation in radio-sensitive NPC xenografts.
The Effects of Making Public Service Employees Aware of Their Prosocial and Societal Impact: A Microintervention
Authors: Vogel Dominik , Willems Jurgen 
Published: January 2020

AbstractOver the past decade, practitioners and scholars have intensified the discussions around people’s expectations from their jobs and how public and private organizations can succeed in the war for talent. In this context, it has become obvious that people not only seek high salaries and career opportunities but also meaningfulness in their daily tasks. Although many public service jobs offer opportunities to help others (prosocial impact) or contribute to society (societal impact), employees tend to become accustomed to these positive aspects or forget about them. This article tests whether a microintervention that emphasizes employees’ prosocial or societal impact can positively affect their well-being, intention to stay in the job, and willingness to recommend their respective jobs to others. The combined results of three preregistered experiments reveal that microinterventions can indeed have these effects, particularly if they focus on creating awareness about the jobs’ societal impact.
Spontaneous rupture of a splenic artery aneurysm treated with a spleen-preserving procedure: a case report
Authors: Effraemidou Eleni , Souftas Vasileios , Kofina Konstantinia , Karanikas Michael , Lyratzopoulos Nikolaos 
Published: January 2020

Abstract
Splenic artery aneurysm is a rare and life-threatening condition, in case of spontaneous rupture. A rare case of such a rupture, treated successfully with an endovascular procedure, is presented. A 21-year-old man presented to the emergency department after an episode of loss of consciousness. After initial conservative treatment, he developed hemodynamic instability 12 hours later, with concurrent diffuse abdominal pain. Abdominal CT revealed a ruptured splenic artery aneurysm, which was immediately treated with coil embolization. The patient had an uneventful recovery and was discharged on the 12th day after the procedure. Although open surgery is the choice of treatment in cases of ruptured splenic artery aneurysms, endovascular embolization can also be considered a safe procedure with low complication and mortality rates.
A new method of determining brightness and size of cometary nuclei
Authors: Paradowski Mieczyslaw Leszek 
Published: January 2020

ABSTRACTThis paper presents a new method of determining the brightness and size of cometary nuclei that has been applied to the following 32 observed comets: 2P/Encke, 29P/Schwassmann-Wachmann 1, 102P/Shoemaker 1, 103P/Hartley 2, 168P/Hergenrother, 189P/NEAT, 260P/McNaught, 315P/LONEOS, P/2012 NJ (La Sagra), P/2013 J2 (McNaught), C/2006 S3 (LONEOS), C/2009 P1 (Garradd), C/2010 S1 (LINEAR), C/2010 X1 (Elenin), C/2011 J2 (LINEAR), C/2011 L4 (PANSTARRS), C/2011 W3 (Lovejoy), C/2012 F6 (Lemmon), C/2012 J1 (Catalina), C/2012 K1 (PANSTARRS), C/2012 S1 (ISON), C/2013 R1 (Lovejoy), C/2013 US10 (Catalina), C/2014 B1 (Schwartz), C/2014 E2 (Jacques), C/2014 Q2 (Lovejoy), C/2015 F4 (Jacques), C/2015 V2 (Johnson), C/2015 ER61 (PANSTARRS), C/2015 VL62 (Lemmon-Yeung-PANSTARRS), C/2016 A8 (LINEAR), and C/2017 O1 (ASASSN). The method consists in fitting the exponential decay function to the measured coma brightness in the aperture radius range from 0.5 to 2 pixels, and extrapolating this function to 0 pixels to obtain nuclear brightness. The R-band absolute nuclear magnitude RN(1, 1, 0), and the logarithm of the nucleus diameter DN expressed in kilometres, follow a linear dependence with the absolute total visual magnitude H. This dependence is of the form RN(1, 1, 0) = 12.5943 + 0.648H, and log DN[km] = 1.2415 − 0.13H. Comet 2P/Encke does not fit this dependence due to its high nuclear density of 800 kg m−3 (Sosa & Fernández 2009). The mean bulk density of the observed comets (except 2P/Encke) is 453 ± 29 kg m−3. The accuracy of the method in determining the brightness of comet nuclei at a level of 1σ is 8 per cent.
A robust, template-free approach to precise radial velocity extraction
Authors: Rajpaul V M , Aigrain S , Buchhave L A 
Published: January 2020

ABSTRACT
Doppler spectroscopy is a powerful tool for discovering and characterizing exoplanets. For decades, the standard approach to extracting radial velocities (RVs) has been to cross-correlate observed spectra with a weighted template mask. While still widely used, this approach is known to suffer numerous drawbacks, and so in recent years increasing attention has been paid to developing new and improved ways of extracting RVs. In this proof-of-concept paper, we present a simple yet powerful approach to RV extraction. We use Gaussian processes to model and align all pairs of spectra with each other; we combine the pairwise RVs thus obtained to produce accurate differential stellar RVs, without constructing any template. Doing this on a highly localized basis enables a data-driven approach to identifying and mitigating spectral contamination, even without the input of any prior astrophysical knowledge. We show that a crude implementation of this method applied to an inactive standard star yields RVs with comparable precision to and significantly lower rms variation than RVs from industry-standard pipelines. Though amenable to numerous improvements, even in its basic form presented here our method could facilitate the study of smaller planets around a wider variety of stars than has previously been possible.
Galactic conformity in both star formation and morphological properties
Authors: Otter Justin A , Masters Karen L , Simmons Brooke , Lintott Chris J 
Published: January 2020

ABSTRACT
We investigate one-halo galactic conformity (the tendency for satellite galaxies to mirror the properties of their central) in both star formation and morphology using a sample of 8230 galaxies in 1266 groups with photometry and spectroscopy from the Sloan Digital Sky Survey, morphologies from Galaxy Zoo and group memberships as determined by Yang et al. This is the first paper to investigate galactic conformity in both star formation and visual morphology properties separately. We find that the signal of galactic conformity is present at low significance in both star formation and visual morphological properties, however it is stronger in star formation properties. Over the entire halo mass range we find that groups with star-forming (spiral) centrals have, on average, a fraction 0.18 ± 0.08 (0.08 ± 0.06) more star-forming (spiral) satellites than groups with passive (early-type) centrals at a similar halo mass. We also consider conformity in groups with four types of central: passive early-types, star-forming spirals, passive spirals, and star-forming early-types (which are very rarely centrals), finding that the signal of morphological conformity is strongest around passive centrals regardless of morphology; although blue spiral centrals are also more likely than average to have blue spiral satellites. We interpret these observations of the relative size of the conformity signal as supporting a scenario where star formation properties are relatively easily changed, while morphology changes less often/more slowly for galaxies in the group environment.
The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution
Authors: Ganesh Sravya , Horvat Filip , Drutovic David , Efenberkova Michaela , Pinkas Dominik , Jindrova Anna , Pasulka Josef , Iyyappan Rajan , Malik Radek , Susor Andrej , Vlahovicek Kristian , Solc Petr , Svoboda Petr 
Published: January 2020

AbstractTens of thousands of rapidly evolving long non-coding RNA (lncRNA) genes have been identified, but functions were assigned to relatively few of them. The lncRNA contribution to the mouse oocyte physiology remains unknown. We report the evolutionary history and functional analysis of Sirena1, the most expressed lncRNA and the 10th most abundant poly(A) transcript in mouse oocytes. Sirena1 appeared in the common ancestor of mouse and rat and became engaged in two different post-transcriptional regulations. First, antisense oriented Elob pseudogene insertion into Sirena1 exon 1 is a source of small RNAs targeting Elob mRNA via RNA interference. Second, Sirena1 evolved functional cytoplasmic polyadenylation elements, an unexpected feature borrowed from translation control of specific maternal mRNAs. Sirena1 knock-out does not affect fertility, but causes minor dysregulation of the maternal transcriptome. This includes increased levels of Elob and mitochondrial mRNAs. Mitochondria in Sirena1−/− oocytes disperse from the perinuclear compartment, but do not change in number or ultrastructure. Taken together, Sirena1 contributes to RNA interference and mitochondrial aggregation in mouse oocytes. Sirena1 exemplifies how lncRNAs stochastically engage or even repurpose molecular mechanisms during evolution. Simultaneously, Sirena1 expression levels and unique functional features contrast with the lack of functional importance assessed under laboratory conditions.
Emergency personnel neuroticism, health and lifestyle: A UK Biobank study
Authors: Mutambudzi M , Flowers P , Demou E 
Published: January 2020

Abstract

Background
Emergency personnel face unpredictable and challenging incidents and their resilience and ability to cope influences their well-being. Personality traits, such as neuroticism, are postulated to be robust predictors of health and health behaviours. Despite evidence in the general population that neuroticism can positively impact health and health behaviours; to date neuroticism in emergency personnel has primarily been associated with adverse health outcomes.

Aims
To assess whether neuroticism has a negative or positive impact on subjective and objective health and health behaviours in emergency personnel.

Methods
This study used cross-sectional UK Biobank baseline data of emergency personnel (police, firemen and paramedics). Logistic regression models examined the strength of the associations of neuroticism tertiles with subjective (self-reported overall health and chronic conditions) and objective health (abdominal obesity) and self-reported smoking, sleeping, alcohol use and exercise levels.

Results
High neuroticism was positively associated with poorer subjective health outcomes in all emergency personnel (n = 2483). The association between neuroticism and chronic disease/s was significant for police in the second (odds ratio [OR] = 1.93, 95% confidence interval [CI] = 1.15–1.94) and third (OR = 1.62, 95% CI = 1.21–2.16) neuroticism tertiles. Neuroticism in firemen was associated with reduced abdominal obesity (OR = 0.49, 95% CI = 0.25–0.96) and increased exercise (OR = 2.14, 95% CI = 1.07–4.25).

Conclusions
We observed positive and negative associations between neuroticism and health outcomes and behaviours. While differences were observed across the emergency personnel groups, more research is needed to better understand how personality traits may impact health in workers with physically and mentally intense jobs.
Ixekizumab treatment of biologic-naïve patients with active psoriatic arthritis: 3-year results from a phase III clinical trial (SPIRIT-P1)
Authors: Chandran Vinod , van der Heijde Désirée , Fleischmann Roy M , Lespessailles Eric , Helliwell Philip S , Kameda Hideto , Burgos-Vargas Ruben , Erickson Janelle S , Rathmann Suchitrita S , Sprabery Aubrey Trevelin , Birt Julie A , Shuler Catherine L , Gallo Gaia 
Published: January 2020

Abstract

Objective
The aim was to assess the safety and efficacy of up to 156 weeks of ixekizumab (an IL-17A antagonist) treatment in PsA patients.

Methods
In a phase III study, patients naïve to biologic treatment were randomized to placebo, adalimumab 40 mg every 2 weeks (ADA; active reference) or ixekizumab 80 mg every 2 weeks (IXEQ2W) or every 4 weeks (IXEQ4W) after an initial dose of 160 mg. At week 24 (week 16 for inadequate responders), ADA (after 8-week washout) and placebo patients were re-randomized to IXEQ2W or IXEQ4W. Outcomes were evaluated using a modified non-responder imputation [linear extrapolation for radiographic progression (modified total Sharp score = 0)] during extended treatment until week 156.

Results
Of 417 patients, 381 entered the extension, and 243 of 381 (63.8%) completed the 156-week study. Incidence rates of treatment-emergent and serious adverse events, respectively, were 38.0 and 5.2 with IXEQ2W (n = 189) and 38.1 and 8.0 with IXEQ4W (n = 197). One death occurred (IXEQ4W). With IXEQ2W and IXEQ4W, respectively, the response rates persisted to week 156 as measured by the ACR response ≥20% (62.5 and 69.8%), ≥50% (56.1 and 51.8%) and ≥70% (43.8 and 33.4%), psoriasis area and severity index (PASI) 75 (69.1 and 63.5%), PASI 90 (64.5 and 51.2%) and PASI 100 (60.5 and 43.6%). Inhibition of radiographic progression also persisted to week 156 in 61% of IXEQ2W and 71% of IXEQ4W patients.

Conclusion
In this 156-week study of ixekizumab, the safety profile remained consistent with previous reports, and improvements in signs and symptoms of PsA were observed, including persistent low rates of radiographic progression.

Trial registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT01695239, EudraCT 2011-002326-49.