bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computing Topological Indices for Para-Line Graphs of Anthracene
Authors: Zhang Zhiqiang , Mufti Zeshan Saleem , Nadeem Muhammad Faisal , Ahmad Zaheer , Siddiqui Muhammad Kamran , Farahani Muhammad Reza 
Published: December 2019

AbstractAtoms displayed as vertices and bonds can be shown by edges on a molecular graph. For such graphs we can find the indices showing their bioactivity as well as their physio-chemical properties such as the molar refraction, molar volume, chromatographic behavior, heat of atomization, heat of vaporization, magnetic susceptibility, and the partition coefficient. Today, industry is flourishing because of the interdisciplinary study of different disciplines. This provides a way to understand the application of different disciplines. Chemical graph theory is a mixture of chemistry and mathematics, which plays an important role in chemical graph theory. Chemistry provides a chemical compound, and graph theory transforms this chemical compound into a molecular graphwhich further is studied by different aspects such as topological indices.We will investigate some indices of the line graph of the subdivided graph (para-line graph) of linear-[s] Anthracene and multiple Anthracene.
The Risks of Hard Brexit for the United Kingdom
Authors: Perri Salvatore 
Published: December 2019

Abstract
The aim of this paper is to analyze the potential consequences of Hard Brexit for the economy of the United Kingdom. From the theoretical and empirical literature, there are no reasons to expect good performances in the medium long term for the British economy. The Hard Brexit scenario will damage the UK perspectives of growth by increasing costs of production, difficulties to export, a quantitative and qualitative deterioration in labor force, the escape of financial operators and of the legal offices of multinationals from the London square, the isolation of UK in the international geopolitical context and riskiness for the same integrity of United Kingdom. After the vote, we can observe a resilience of the UK economy that could be determined by the accumulation of stocks in anticipation of a traumatic exit, but also, to an important depreciation of pound that is producing inflation and losing value of real wages.
A Digital Euro to Compete With Libra
Authors: Mayer Thomas 
Published: December 2019

Abstract
On 18 June 2019 a group of 28 companies led by Facebook published a White Paper proposing the creation of a new crypto currency named Libra. The initiative could give the digitalization of money a big boost. Digitalization would also give the euro a viable long term perspective, which it is unlikely to have in the credit money system. Credit money needs a state for its reinsurance that cannot be created for the euro area. Digital money, on the other hand, can exist without a state guarantee.
Different signaling and functionality of Rac1 and Rac1b in the progression of lung adenocarcinoma
Authors: Seiz Julia R. , Klinke Johannes , Scharlibbe Laura , Lohfink Dirk , Heipel Marisa , Ungefroren Hendrik , Giehl Klaudia , Menke Andre 
Published: December 2019

Abstract
Rac1 is a ubiquitously expressed Rho GTPase and an important regulator of the actin cytoskeleton. Its splice variant Rac1b exhibits a 19-amino acid (aa) in-frame insertion and is predominantly active. Both proteins were described in tumorigenesis or metastasis. We investigated the contribution of Rac1 and Rac1b to tumor progression of human non-small-cell lung adenocarcinoma (NSCLA). Rac1 protein was present in 8/8 NSCLA cell lines analyzed, whereas Rac1b was expressed in only 6/8. In wound-healing assays, enhanced green fluorescence protein (EGFP)-Rac1 slightly decreased cell migration, whereas proliferation was increased in both, Rac1- and Rac1b-expressing cells. In the in vivo chorioallantoic invasion model, EGFP-Rac1-expressing cells formed more invasive tumors compared to EGFP-Rac1b. This increased invasiveness correlated with enhanced phosphorylation of p38α, AKT and glycogen synthase kinase 3β (GSK3β), and activation of serum response- and Smad-dependent gene promoters by Rac1. In contrast, Rac1b solely activated the mitogen-activated protein kinase (MAPK) JNK2, together with TCF/LEF1- and nuclear factor kappa B (NFκB)-responsive gene reporters. Rac1b, as Rac1, phosphorylated p38α, AKT and GSK3β. Knockdown of the splicing factor epithelial splicing regulatory protein 1 (ESRP1), which mediates out-splicing of exon 3b from Rac1 pre-messenger RNA, resulted in increased Rac1b messenger RNA (mRNA) and suppression of the epithelial-mesenchymal transition (EMT)-associated transcription factor ZEB1. Our data demonstrate different signaling and functional activities of Rac1 and Rac1b and an important role for Rac1 in lung cancer metastasis.
Dr. NO and Mr. Toxic – the versatile role of nitric oxide
Authors: Porrini Constance , Ramarao Nalini , Tran Seav-Ly 
Published: December 2019

Abstract
Nitric oxide (NO) is present in various organisms from humans, to plants, fungus and bacteria. NO is a fundamental signaling molecule implicated in major cellular functions. The role of NO ranges from an essential molecule to a potent mediator of cellular damages. The ability of NO to react with a broad range of biomolecules allows on one hand its regulation and a gradient concentration and on the other hand to exert physiological as well as pathological functions. In humans, NO is implicated in cardiovascular homeostasis, neurotransmission and immunity. However, NO can also contribute to cardiovascular diseases (CVDs) or septic shock. For certain denitrifying bacteria, NO is part of their metabolism as a required intermediate of the nitrogen cycle. However, for other bacteria, NO is toxic and harmful. To survive, those bacteria have developed processes to resist this toxic effect and persist inside their host. NO also contributes to maintain the host/microbiota homeostasis. But little is known about the impact of NO produced during prolonged inflammation on microbiota integrity, and some pathogenic bacteria take advantage of the NO response to colonize the gut over the microbiota. Taken together, depending on the environmental context (prolonged production, gradient concentration, presence of partners for interaction, presence of oxygen, etc.), NO will exert its beneficial or detrimental function. In this review, we highlight the dual role of NO for humans, pathogenic bacteria and microbiota, and the mechanisms used by each organism to produce, use or resist NO.
Diffuse or hitch a ride: how photoreceptor lipidated proteins get from here to there
Authors: Frederick Jeanne M. , Hanke-Gogokhia Christin , Ying Guoxin , Baehr Wolfgang 
Published: December 2019

Abstract
Photoreceptors are polarized neurons, with specific subcellular compartmentalization and unique requirements for protein expression and trafficking. Each photoreceptor contains an outer segment (OS) where vision begins, an inner segment (IS) where protein synthesis occurs and a synaptic terminal for signal transmission to second-order neurons. The OS is a large, modified primary cilium attached to the IS by a slender connecting cilium (CC), the equivalent of the transition zone (TZ). Daily renewal of ~10% of the OS requires massive protein biosynthesis in the IS with reliable transport and targeting pathways. Transport of lipidated (‘sticky’) proteins depends on solubilization factors, phosphodiesterase δ (PDEδ) and uncoordinated protein-119 (UNC119), and the cargo dispensation factor (CDF), Arf-like protein 3-guanosine triphosphate (ARL3-GTP). As PDE6 and transducin still reside prominently in the OS of PDEδ and UNC119 germline knockout mice, respectively, we propose the existence of an alternate trafficking pathway, whereby lipidated proteins migrate in rhodopsin-containing vesicles of the secretory pathway.
Cell Line Classification Using Electric Cell-Substrate Impedance Sensing (ECIS)
Authors: Gelsinger Megan L. , Tupper Laura L. , Matteson David S. 
Published: December 2019

Abstract
We present new methods for cell line classification using multivariate time series bioimpedance data obtained from electric cell-substrate impedance sensing (ECIS) technology. The ECIS technology, which monitors the attachment and spreading of mammalian cells in real time through the collection of electrical impedance data, has historically been used to study one cell line at a time. However, we show that if applied to data from multiple cell lines, ECIS can be used to classify unknown or potentially mislabeled cells, factors which have previously been associated with the reproducibility crisis in the biological literature. We assess a range of approaches to this new problem, testing different classification methods and deriving a dictionary of 29 features to characterize ECIS data. Most notably, our analysis enriches the current field by making use of simultaneous multi-frequency ECIS data, where previous studies have focused on only one frequency; using classification methods to distinguish multiple cell lines, rather than simple statistical tests that compare only two cell lines; and assessing a range of features derived from ECIS data based on their classification performance. In classification tests on fifteen mammalian cell lines, we obtain very high out-of-sample predictive accuracy. These preliminary findings provide a baseline for future large-scale studies in this field.
Surviving Defeat: battlefield surrender in classical Greece
Authors: Crowley Jason 
Published: December 2019

AbstractThe fate of war captives has been extensively explored, as, indeed, has the way that fate affects both the conduct and course of hostilities. Nevertheless, little research has been conducted on the link that connects the two, namely the act of surrender, and this is especially true of classical Greece. This article seeks to remedy this situation by answering three interlinked questions, namely: how men attempted to surrender on the battlefields of classical Greece; in what tactical conditions they did so; and finally, what prospects they had of surviving the process.
Auxiliaries and War-Financing in the Roman Republic
Authors: Gauthier François 
Published: December 2019

Abstract
Auxiliaries are usually studied in the late Republic or the Imperial period. Despite this emphasis in modern research, auxiliaries were employed in substantial numbers during the third and second centuries BCE. Auxiliaries did make a crucial contribution to the Roman war effort in the Middle Republic, providing a substantial part of Rome’s military manpower. These troops were most often financed by the community providing them, allowing the Roman state to save a great deal of money if similar numbers of Roman citizens had been deployed instead. This enabled the Roman state to significantly bolster its ability to project military power without having to implement additional financing mechanisms. Along with the use of auxiliaries, the suspension of tributum after the third Macedonian War seemed to have followed a policy of decreasing the burden of financing war for Roman assidui.
A case report of generalized tetanus in a 42-year-old man with dental infection
Authors: Ulfa Maria , Husna Nuril Auliya 
Published: December 2019

Abstract

Background
In the post-vaccination era, as it is today, generalized tetanus is a rare diagnosis, although mortality and morbidity continue to increase significantly throughout the world. Infection occurs when the Clostridium tetani spores are introduced into wounds, skin lesions and infections. The symptoms often begin with stiffness or spasms in the jaw muscles; they are called trismus or “lockjaw” and/or then spread to the neck and abdominal muscles.

Case presentation
This is a report of a 42-year-old man who was referred to the hospital with dysphagia, rigidity and trismus. He was diagnosed with generalized tetanus with a Philips score of 15. The patient was admitted to the isolation unit, received treatment that included procaine penicillin, metronidazole, diazepam, human tetanus immunoglobulin (TIG) and anti-tetanus serum (ATS). Treatment was considered according to the guidelines of the World Health Organization, and also, the drug dose has no adverse event reaction during the treatment.

Conclusion
The therapeutic response is related to the identification and appropriate treatment, especially in hospitalized patients with inadequate immunization so that patients recover soon.
Microarray findings in pregnancies with oligohydramnios – a retrospective cohort study and literature review
Authors: Singer Amihood , Maya Idit , Sukenik-Halevy Rivka , Tenne Tamar , Lev Dorit , Ben Shachar Shay , Sagi-Dain Lena 
Published: December 2019

Abstract

Objective
To explore the risk for abnormal chromosomal microarray analysis (CMA) findings in pregnancies with oligohydramnios.

Methods
Data from all CMA analyses performed due to oligohydramnios between 2013 and 2017 were retrospectively obtained from the Israeli Ministry of Health database. The rate of clinically significant (pathogenic and likely pathogenic) findings was compared to a local cohort of pregnancies with normal ultrasound, yielding a 1.4% rate of abnormal CMA results. In addition, a search was conducted through the PubMed database addressing the issue.

Results
Fifty CMA analyses were performed due to oligohydramnios. The 2% risk for clinically significant CMA finding in pregnancies with oligohydramnios did not differ from the control population of 5541 pregnancies with normal ultrasound – relative risk (RR) 1.4 [95% confidence interval (CI) 0.2–10.2]. Literature search yielded 394 titles, of which four relevant articles were selected, all using fetal karyotyping.

Conclusion
There is yet insufficient evidence to support invasive prenatal testing in pregnancies with isolated oligohydramnios.
Clinical outcome of prenatally suspected cardiac rhabdomyomas of the fetus
Authors: Altmann Judith , Kiver Verena , Henrich Wolfgang , Weichert Alexander 
Published: December 2019

Abstract

Background
The main objective of this retrospective analysis in a large tertiary center was the clinical outcome of prenatally diagnosed cardiac rhabdomyomas as well as the identification of factors influencing fetal prognosis.

Methods
A total of 45 cases of fetuses with prenatally suspected rhabdomyoma and their clinical outcome were analyzed retrospectively. A review of the literature was also performed.

Results
In five cases, after a tuberous sclerosis complex (TSC) mutation had been confirmed, termination of pregnancy was chosen. In 30 cases postnatal data were available. In 93% TSC was confirmed clinically or by mutational analysis. Two thirds of fetuses presented with multiple tumor while one third presented with a solitary tumor. In two fetuses mild pericardial effusions were observed. Another three fetuses presented with extrasystoles prenatally. No hydrops fetalis or fetal perinatal demise were observed. After birth 41% of the children suffered from arrhythmia including supra- and ventricular tachycardia, Wolff-Parkinson-White syndrome and atrioventricular block. One child received a Fontan procedure with Glenn anastomosis. Another child with a dilatative cardiomyopathy and a left ventricular ejection fraction of 15% died. Fifty-two percent of the children with TSC suffered from epilepsy ranging from absence epilepsy and West syndrome to generalized seizures with a frequency of up to 40 per day. Two children underwent neurosurgery to remove the epileptogenic focus. One child suffered from TSC and Lesch-Nyhan disease. In another case Beckwith-Wiedemann syndrome was identified as the causative disorder.

Conclusion
Rhabdomyoma are rare, benign tumors. There is an association with TSC. In the majority of cases rhabdomyoma are not hemodynamically relevant and do not increase in size. The quality of life of affected patients is impaired particularly due to epilepsy and psychomotor retardation.
An evaluation of thermal infrared cameras for surveying hedgehogs in parkland habitats
Authors: Bowen Clare , Reeve Nigel , Pettinger Tess , Gurnell John 
Published: December 2019

Abstract
We tested the effectiveness of thermal imaging cameras (TICs; model FLIR E60) for finding hedgehogs Erinaceus europaeus (Linnaeus, 1758) while carrying out volunteer spotlighting surveys in parkland habitats in Central London. Systematic and standardised surveys were carried out in The Regent’s Park, London in spring and autumn from 2016 to 2018. Night-time surveys were carried out in seven designated zones within the park by groups of 4–6 volunteers, three (occasionally four) with bright torches and one with a TIC. Hedgehogs were detected on 316 occasions; 166 using TICs, 133 using torches, 11 by sound and six unassisted. Hedgehogs were detected at significantly greater distances with TICs [mean = 30 m, standard deviation (SD) = 22.8 m, n = 166] than with torches (mean = 12 m, SD = 11.2 m, n = 133). We conclude that TICs operated by volunteers were particularly effective at detecting hedgehogs in our parkland surveys and using TICs to supplement torches in spotlighting surveys should be tested in other places, especially where there is a considerable amount of open habitat.
Social Work Between Germany and Mandatory Palestine: Pre- and Post-Immigration Biographies of Female Jewish Practitioners as a Case Study of Professional Reconstruction
Authors: Halpern Ayana , Lau Dayana 
Published: December 2019

Abstract
When social work emerged as a profession in the first decades of the 20th century, it was strongly influenced by emancipatory motives introduced by various sociocultural and religious movements, and at the same time devoted itself to the construction and maintenance of a powerful welfare and nation state. Transnational agents and social movements promoted these processes and played a crucial role in establishing and developing national welfare systems and relevant professional discourses. This article examines the gendered construction of the social work profession through the transnational history of early social work between Germany and the Jewish community in Palestine in the first half of the 20th century. By adopting a biographical approach to the specific paths of Jewish women practitioners who had been educated in German-speaking countries, immigrated to mandatory Palestine, and engaged themselves in the emerging field of social work, we will trace the construction of the profession as deeply embedded in social power relations. At the same time, we will trace its (re)construction as led mainly by female pioneers, who were concerned with emancipation, discrimination and migration.
„Ich Kam, Sah und Explodierte“ – Eine Episode aus dem Leben Sammy Gronemanns
Authors: Piotrkowski Meron-Martin 
Published: December 2019

Abstract
This article focuses on a particular episode in Sammy Gronemann’s life that occurred in 1902 and is briefly described in his memoires, Erinnerungen. Gronemann was asked to travel to Mainz for a propaganda lecture on behalf of the Zionist Movement in which he caused an uproar. Earlier in the year, the Jewish-orthodox newspaper Der Israelit of Mainz had published a slanderous article on the Zionist bank, the Jewish Colonial Trust, for which it was sued by the Zionist leadership. In the midst of the trial against the paper and its editor-in-chief, Oskar Lehmann, efforts were made to bring the trial to a quick end by means of a settlement. During Gronemann’s talk in Mainz, he spotted Lehmann in the audience and entered into a tirade. He publicly insulted Lehmann, who angrily left the venue. This caused an uproar and jeopardized the leverage of the Zionists in the settlement negotiations and the trial’s speedy conclusion. This paper provides the background to the events, discusses its outcome, and puts the episode in its historical context.
The Creature, the First Question: An Essay
Authors: Shahar Galili 
Published: December 2019

Abstract
The article deals with the notion of the “Creature” as being displayed in Joseph Wittig’s essay titled Der Weg zur Kreatur. This piece by Wittig (1879–1949), one of the co-founders of the journal Die Kreatur, himself a banished Catholic thinker, an excommunicated theologian, was published in the third volume of the journal in 1929/1930. The major argument to be presented here, following Wittig’s essay, concerns the path (but also the method) into the world of the creature, namely, the way-back, a regression, which depends on counter-movements, suspensions, gestures of recollection and witnessing. This path is based on the potentialities of the “first question” – a demand for the first word, a proper name for the silent, forgotten creature, being invited to encounter. The encounter with the creatures is a method of thinking, a way of being in this world that is based on the possibility of asking rightly the “first question”. For what this question performs is an attention, hearing of, a method of listening. In asking the question of (and for) the creature, language itself turns toward the world of the creation, in a search for a proper name, calling creation to be heard, to belong.
„We Have to Watch ou[t] for [the] Propaganda Effect“ – Ephraim Kishon und Friedrich Torberg publizieren „israelischen Humor“ zum Sechstagekrieg 1967
Authors: Körner Birgit M. 
Published: December 2019

Abstract
Zum Sechstagekrieg und dessen Folgen veröffentlichte der israelische Autor Ephraim Kishon in rascher Folge drei Bücher. Zwei davon sind zum Teil in starker Bearbeitung durch den österreichisch jüdischen Autor Friedrich Torberg auf Deutsch erschienen. Der vorliegende Aufsatz untersucht die Parameter dieses Gemeinschaftswerks zum ersten Mal vergleichend und auf der Basis unveröffentlichter Briefe. Die von Torberg vorgenommenen Veränderungen betreffen besonders Vergleiche mit NS-Deutschland, Verweise auf den Holocaust sowie den ironischen Umgang mit antisemitischen Stereotypen.
Des Weiteren wird deutlich, dass sich Kishon in seinen Texten auf die beiden zentralen Strömungen des „jüdischen Humors“ zu Beginn des 20. Jahrhunderts bezieht: die in der deutschsprachigen Rezeption dominant wahrgenommenen ,harmlosen‘ Humoresken in der Tradition des osteuropäischen „jüdischen Witzes“ und die von Meyer-Sickendiek (2009) beschriebene westjüdische Tradition des literarischen Sarkasmus. Mit den beiden Bänden zum Sechstagekrieg wurde das deutschsprachige Publikum stärker mit der sarkastischen Seite von Kishons Humor konfrontiert.
Ad Acta: Nachgelassenes in Jerusalem
Authors: Weiss Yfaat 
Published: December 2019

Abstract
Auf dem 1913 in Wien stattfindenden Zionistischen Kongress wurde Chaim Weizmann beauftragt die auf Achad Ha’am zurückgehende Idee eines jüdisch-geistigen Zentrums durch die Gründung der Hebräischen Universität in Jerusalem zu realisieren. Die Vorstellung einer Universität des jüdischen Volkes blieb auch dann fester Bestandteil der zionistischen Vision, als mit der Balfour-Erklärung von 1917 die politische Begründung einer jüdischen Heimstätte in greifbare Nähe rückte. Beides fand 1925 auf dem Skopusberg bei der Inauguration der Universität in Anwesenheit des britischen Außenministers Arthur James Balfour seinen symbolischen Ausdruck. Mit der Flucht deutsch-jüdischer Gelehrter in den 1930er-Jahren und aufgrund der verzweifelten Versuche jüdischer Studierender, Mittel- und Osteuropa zu verlassen, änderten sich die Erwartungen an die Universität. Von nun an sollte sie zu einem „Nachtasyl“ werden. Bald darauf, ab Mitte der 1940er-Jahre, geriet sie zum Kampfschauplatz zwischen Juden und Arabern, um schließlich zur Universität des jüdischen Staates zu avancieren und als Ort der Gelehrsamkeit inmitten einer geteilten Stadt zu wirken. Der Aufsatz bietet einen Blick in das erst vor Kurzem konservierte Historische Archiv der Hebräischen Universität, um diese Entwicklungen zu erhellen.