bluuebunny/crossref_metadata_2025_split huggingface dataset:
La mediación pedagógica en el sistema familiar frente a los contenidos en televisión, internet y redes sociales online
Authors: Silva Pertuz Marta , Silva Silva Adriana , García Jiménez Andrés F. 
Published: March 2020

Este artículo es producto de una investigación de mixta donde predominó el énfasis en la descripción de los resultados, con características cuantitativas de la información obtenida a través del cuestionario aplicado. El diseño descriptivo permitió observar y reflexionar sobre las mediaciones pedagógicas que se dan en los contextos familiares frente a la recepción y consumo de productos y servicios ofertados por la televisión, internet y las redes sociales on line. Los participantes fueron estudiantes universitarios (16 y 24 años de edad) a los que se les aplicó un cuestionario y un diario de observación. Se realizó una triangulación de los resultados de la observación participante y de los cuestionarios aplicados. Se encontró que existía un tipo de mediación familiar frente a los contenidos televisivos. Sin embargo, no se encontró un indicador que aclare si las familias están mediando los contenidos que circulan en internet. Esto permite una oportunidad para plantear estrategias de comunicación familiar, que posibiliten una injerencia de los padres / cuidadores o acompañantes sobre estos contenidos, teniendo en cuenta el ciclo vital individual y familiar.
Silencing ofMutatorElements in Maize Involves Distinct Populations of Small RNAs and Distinct Patterns of DNA Methylation
Authors: Burgess Diane , Li Hong , Zhao Meixia , Kim Sang Yeol , Lisch Damon 
Published: March 2020

AbstractTransposable elements (TEs) are a ubiquitous feature of plant genomes. Because of the threat they post to genome integrity, most TEs are epigenetically silenced. However, even closely related plant species often have dramatically different populations of TEs, suggesting periodic rounds of activity and silencing. Here, we show that the process of de novo methylation of an active element in maize involves two distinct pathways, one of which is directly implicated in causing epigenetic silencing and one of which is the result of that silencing. Epigenetic changes involve changes in gene expression that can be heritably transmitted to daughter cells in the absence of changes in DNA sequence. Epigenetics has been implicated in phenomena as diverse as development, stress response, and carcinogenesis. A significant challenge facing those interested in investigating epigenetic phenomena is determining causal relationships between DNA methylation, specific classes of small RNAs, and associated changes in gene expression. Because they are the primary targets of epigenetic silencing in plants and, when active, are often targeted for de novo silencing, TEs represent a valuable source of information about these relationships. We use a naturally occurring system in which a single TE can be heritably silenced by a single derivative of that TE. By using this system it is possible to unravel causal relationships between different size classes of small RNAs, patterns of DNA methylation, and heritable silencing. Here, we show that the long terminal inverted repeats within Zea mays MuDR transposons are targeted by distinct classes of small RNAs during epigenetic silencing that are dependent on distinct silencing pathways, only one of which is associated with transcriptional silencing of the transposon. Further, these small RNAs target distinct regions of the terminal inverted repeats, resulting in different patterns of cytosine methylation with different functional consequences with respect to epigenetic silencing and the heritability of that silencing.
Untold Stories: A Study of Sudanese and Syrian Refugees in Estonia
Authors: Islam Aminul 
Published: March 2020

The aim of this study was to explore the coping resources and the present and past experiences of two groups with refugee experiences in Estonia through narrative approach. Avert narratives, Struggling narratives, Instantaneous narratives, Boundary narratives, and Re-occurrence narratives identified through the interviews with 12 refugees. Differences between this two groups and individual accounts were also identified. The structure of the narratives, identity construction while in exile and coping mechanism through the narratives shaped their life stories and lives in exile. One significant outcome of this study is the lack of compatibility of the stories between two groups, through which five narratives established to elaborate the variety of their accounts.
ANALISIS SEMIOTIKA MAKNA KESENDIRIAN PADA LIRIK LAGU “RUANG SENDIRI” KARYA TULUS
Authors: Nathaniel Axcell , Sannie Amelia Wisda 
Published: March 2020

This article explores the meaning of solitude in the lyrics of Tulus' song "Ruang Sendiri" using Roland Barthes' semiotic analysis. There are three expressed meanings namely denotation, connotation, and myth. To explain all three meanings of solitude in the lyrics of the song are used Roland Barthes' semiotic theory. The research method used is interpretive qualitative method or inductive way of thinking, which is a way of thinking from special to general. To collect data are used study of document by searching and obtaining from various sources contained the required data. The results of a semiotic study of the lyrics to the song "Ruang Sendiri" are as follows. The denotation meaning of the lyrics of the song "Ruang Sendiri " is the desire of the songwriter to feel alone, feel free, and without a lover. The connotation is boredom to his partner, not know how his feeling to his lover. The meaning of the myth is the songwriter wants to convey that solitude, doing anything alone, not always together are something needed by everyone who builds a love relationship.
Ghost cell glaucoma after intravitreous injection of ranibizumab in proliferative diabetic retinopathy
Authors: XU Jun , ZHAO Meng , LI Jipeng , LIU Ningpu 
Published: March 2020

Abstract
BACKGROUND: The development of ghost cell glaucoma in patients with PDR after intravitreous injection (IV) was rare. Here we reported a series of patients with PDR who received Intravitreous Ranibizumab (IVR) and developed ghost cell glaucoma and analyzed the potential factors that might be related to the development of ghost cell glaucoma.
METHODS: Retrospective case series study. The medical records of 71 consecutive eyes of 68 PDR patients who received vitrectomy after IVR from January 2015 to January 2017 were reviewed. The development of ghost cell glaucoma after IVR was recorded. Characteristics of enrolled patients were retrieved from their medical charts. Factors associated with ghost cell glaucoma were compared between eyes with the development of ghost cell glaucoma and eyes without the development of ghost cell glaucoma. Variables were further enrolled in a binary backward stepwise logistic regression model, and the model that had the lowest AIC was chosen.
RESULTS: There were 8 out of 71 eyes of the PDR patients developed ghost cell glaucoma after they received IVR. The interval between detection of elevation of intraocular pressure ( IOP ) and IV ranged from 0 to 2 days. Among them, after IVR, there were two eyes had IOP greater than 30mmHg within 30 minutes, four eyes showed normal IOP at 30 min, and then developed ghost cell glaucoma within 1 day, two eyes developed ghost cell glaucoma between 24 and 48 hours. The mean IOP was 46.5±8.0 mmHg. All patients gained normal IOP after vitrectomy without medicine for lowering IOP. The presence of ghost cell glaucoma was associated with tractional retinal detachment (RR=4.60 [2.02~8.48], p=0.004) and fibrovascular membrane involving disk (RR=-3.57 [-7.59~-0.92], p=0.03) (AIC= 39.23，AUC=0.88) in a logistic regression model.
CONCLUSION: Attention to postoperative IOP should be paid to patients with PDR undergoing vitrectomy who receive a preoperative IV of anti-VEGF agents. PDR patients with tractional retinal detachment or fibrovasucular membrane involving optic disc are more likely to develop ghost cell glaucoma after IV.
The quality of and women’s satisfaction with maternal referral practices in Sub-Saharan African low and lower-middle income countries: A systematic review
Authors: Ameyaw Edward Kwabena , Njue Carolyne , Tran Nguyen Toan , Dawson Angela 
Published: March 2020

Abstract
Background: Sub-Saharan African Low and Lower-Middle Income Countries (SSA LLMICs have the highest burden of maternal and neonatal morbidity and mortality in the world. Timely and appropriate obstetric referral to a suitable health facility is a sign of effective health system. This paper presents the findings of a systematic review that aimed to identify what referral practices are delivered according to accepted standards for pregnant women and newborns in SSA LLMICs by competent healthcare providers and in line with the need and wishes of women.
Methods: Six electronic databases were systematically searched for primary data studies (2009-2018) in English reporting on maternal referral practices and their effectiveness. We conducted a content analysis guided by a framework for assessing the quality of maternal referral. The articles defined quality referral as: the timely identification of signal functions, established guidelines or standards, adequate documentation, staff accompaniment and prompt care by competent healthcare providers at the receiving facility.
Results: Seventeen articles were included in the study. Most studies were quantitative (n=11). Two studies reported that women were dissatisfied due to delays in referral processes that affected their health. Most of the articles (10) reported that women were not accompanied to higher levels of healthcare, delays in referral processes, transportation challenges and poor referral documentation. Some healthcare providers administered essential drugs such as misoprostol prior to referral.
Conclusions: Efforts to improve maternal health in LLMICs should aim to enhance maternal healthcare providers’ ability to identify conditions that demand referral. Low cost transport is needed to mitigate transportation barriers of referral. To ensure quality maternal referral, mechanisms should be instituted for health managers at the district level to monitor and evaluate referral documentation, quality and efficiency of maternal referrals on regular basis.
Ups and downs of drug rehab among women: a qualitative study
Authors: boroumandfar zahra , kianpour masoud , afshari maryam 
Published: March 2020

Abstract
Background: According to recent studies, the number of women drug users is dramatically increasing. However, the information on the issue of drug rehab in women is not sufficient, and there are numerous traditional, organizational, political and cultural barriers to the provision of relevant information in this regard in Iran. This study, thus, aimed to explain the factors influencing the decision of these women to stop drug use.
Methods: This qualitative study was conducted in two rehab camps of Isfahan (in Iran) on July to October 2017. Thirty participants (women drug users) were selected through purposive and theoretical sampling until data saturation was reached. Data collection was conducted through semi-structured interviews. The transcribed interviews were analyzed using conventional content analysis.
Results: Based on the analysis of the obtained results, the women's experience of the ups and downs of stopping drug use yielded two themes and nine sub-themes. The themes were “the need for emancipation (the deviated path, being abused, compulsive drug use, acquaintance with God, a supportive family)” and “Sinking factors (non-assisting mates, pro-addictive family, unawareness of assisting official organization and non-government organization, woman’s lack of authority, ineffective opportunities)”.
Conclusions: It was concluded that addiction rehab strategies can lead to a brighter life for women drug users only when they are coupled with open-hearted assistance of the families and women specific rehab centers are established to help them meet their specific needs.
Keywords: Drug Use, Lived Experience, Substance-related disorders, Women's Health, qualitative study
Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women
Authors: Bigman Galya , Adebamowo Sally N. , Yawe King-David Terna , Yilkudi Monday , Olaomi Oluwole , Badejo Olawale , Jedy-Agba Elima , Famooto Ayo , Ezeome Emmanuel , Salu Iliya Karniliyus , Miner Elijah , Anosike Ikechukwu , Achusi Benjamin , Adebamowo Clement 
Published: March 2020

Abstract
Background: Physical activity (PA) is associated with reduced risk of breast cancer and its various subtypes but this association is less well described in African women, particularly in women with triple-negative breast cancer that is more common in Sub-Saharan Africa. In this study, we examined the associations between leisure-time physical activity (LTPA) and breast cancer in total and by subtypes in Nigerian women.Methods: We studied 472 newly diagnosed primary invasive breast cancer patients age-matched (±5years) with 472 controls from the Nigerian Integrative Epidemiology of Breast Cancer (NIBBLE) Study enrolled from January 2014 to July 2016. We derived the average amount of time spent on LTPA per week over the past year using a modified Nurses’ Health Study-II physical activity questionnaire. We calculated the total metabolic equivalents (METs) for each reported LTPA per hour/week (i.e. walking, cycling, and dancing) and compared odds of breast cancer among participants who attained the World Health Organization (WHO) physical activity(PA) recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity/week with those who did not. In addition, we evaluated these by categories of LTPA in quartiles of METs. We used conditional and unconditional logistic regression models to estimate the adjusted Odds Ratio (OR) of LTPA for overall breast cancer and by molecular subtypes. Results: The mean age (SD) of cases, 44.4 (10.0) years, was similar to that of controls, 43.5 (9.5) after matching. The OR for breast cancer among women who attained the WHO PA recommendations compared with those who did not was 0.64 (95% CI: 0.45-0.90). LTPA was associated with 51% reduced odds of hormone receptor-positive and 65% reduced odds of triple-negative breast cancer. We observed a significant dose-response relationship where women with high levels of LTPA had lower odds of overall breast cancer, triple-negative and hormone receptor-positive breast cancer. Conclusions: Increasing LTPA in African women may play a significant role in reducing the incidence of breast cancer, particularly of the more aggressive subtype as triple-negative, which is more prevalent in Sub-Saharan Africa.
Tacrolimus reverses the pemphigus vulgaris serum-enhanced expression of desmoglein in HaCaT cells
Authors: Xie Zhimin , Pan Qiaolin , Shen Xucheng , Zhang Yi , Dai Xiangnong , Ye Xingdong 
Published: March 2020

Abstract
Background: Pemphigus vulgaris (PV) is associated with autoantibodies against desmoglein (Dsg), including Dsg1 and Dsg3. However, the precise mechanism by which acantholysis occurs in response to PV-IgG and the effect of tacrolimus on PV remains unclear. Method: Human HaCaT keratinocytes were co-cultured with DMEM medium containing 5% PV-sera to establish a cell model of pemphigus in order to determine the effect of PV-sera and tacrolimus on Dsg mRNA transcription and protein expression in HaCaT cells. Dsg protein expression in HaCaT cells was evaluated by Western blotting and Dsg mRNA transcription by real-time PCR (RT-PCR ). The distribution of Dsg1 and Dsg3 in HaCaT cells was determined by indirect immunofluorescence (IIF). Results: The application of 5% PV serum resulted in an increase in Dsg1 and Dsg3 transcription and expression levels, whereas tacrolimus suppressed Dsg1 and Dsg3 expression. Tacrolimus inhibited PV serum-induced disruption of cell-cell contacts. Tacrolimus also down-regulated Dsg1 and Dsg3 expression compared with PV. IIF revealed that Dsg1 linear deposits on the surface of HaCaT cells in the PV-sera group disappeared and were replaced by granular and agglomerated fluorescent particles on the cell surface, whereas the Dsg3 linear deposits were still present, however this effect could be reversed by tacrolimus. Conclusion: The Dsg3 antibody disrupts desmosome junctions by inducing endocytosis, resulting in desmosomal dissociation. Tacrolimus can reverse PV serum-induced enhancement Dsg expression in HaCaT cells.
Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis
Authors: xu hanyue , Qin Ling , Zhang Yifan , Zhang Ming 
Published: March 2020

Abstract
Background: To compare the visual outcomes and rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis.Result:Four pertinent publications studying a total of 157 patients with 99 eyes without LHEP and 58 eyes with LHEP were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups, and in two studies the post-operative BCVA had no significant differences between two groups. The rate of restored ellipsoid zone (REZ) was different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.15 (95 % CI, 0.02 to 0.27; P=0.02), and the pooled data revealed an odd ratio of 2.67 (95% CI, 0.50 to 14.25; p = 0.25) in the rate of REZ, comparing the group without LHEP and the group with LHEP.Conclusion: Patients without LHEP had better postoperative BCVA than patients with LHEP, while no significant difference was found in REZ among the two groups.
Aggravated brain injury after neonatal hypoxic ischemia in microglia depleted mice
Authors: Tsuji Shunichiro , Martino Elena Di , Mukai Takeo , Tsuji Shoko , Murakami Takashi , Harris Robert , Blomgren Klas , Aden Ulrika 
Published: March 2020

Abstract
Background: Neuroinflammation plays an important role in neonatal hypoxic-ischemic encephalopathy (HIE). Although microglia are largely responsible for injury-induced inflammatory response, they play beneficial roles in both normal and disease states. However, the effects of microglial depletion on neonatal HIE remain unclear. Methods: Tamoxifen was administered to Cx3cr1 CreER/+ Rosa26 DTA/+ (microglia-depleted model) and Cx3cr1 CreER/+ Rosa26 DTA/- (control) mice at P8 and P9 to assess the effect of microglial depletion. The density of microglia was quantified using Iba-1 staining. Moreover, the proportion of resident microglia after the HI insult was analyzed using flow cytometric analysis. At P10, the HI insult was conducted using the Rice-Vannucci procedure at P10. The infarct size and apoptotic cells were analyzed at P13. Cytokine analyses were performed using quantitative polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA) at P13. Results: At P10, tamoxifen administration induced >99% microglial depletion in DTA + mice. Following HI insult, there was persisted microglial depletion over 97% at P13. Compared to male DTA - mice, male DTA + mice exhibited significantly larger infarct volumes; however, there were no significant differences among females. Moreover, compared to male DTA - mice, male DTA + mice had a significantly higher density of TUNEL + cells in the caudoputamen, cerebral cortex, and thalamus. Moreover, compared to female DTA - mice, female DTA + mice showed a significantly greater number of TUNEL + cells in the hippocampus and thalamus. Compared to DTA - mice, ELISA revealed significantly lower IL-10 and TGF-β levels in both male and female DTA + mice under both normal conditions and after HI (more pronounced). Conclusion: We established a microglial depletion model that aggravated neuronal damage and apoptosis after the HI insult, which was predominantly observed in males.
Establishing the HLS-M-Q18 short version of the European Health Literacy survey questionnaire for the Malaysian context
Authors: Mohamad Emma , Kaundan Manimaran Krishnan , Hamzah Mohammad Rezal , Azlan Arina Anis , Ayub Suffian Hadi , Sern Tham Jen , Ahmad Abdul Latiff 
Published: March 2020

Abstract
Background: The European Health Literacy Survey Questionnaire (HLS-EU-Q47) is becoming a widely used tool to measure health literacy (HL), including in Malaysia. There are efforts to reduce the 47-item scale to parsimonious short item scales that still reflect the assumptions and requirements of the conceptual model. This study used confirmatory factor analysis to reduce the 47-item scale to a short scale that can offer a feasible HL screening tool with sufficient psychometric properties. Methods: A cross-sectional survey was conducted on the Malaysian population based on ethnic distribution to ensure that the short version instrument reflects the country’s varied ethnicities. The survey was administered by well-trained interviewers working for the Ministry of Health Malaysia. A total of 866 responses were obtained. Data was analysed using multi-factorial confirmatory factor analysis (CFA) with categorical variables. Results: The analysis resulted in a satisfactory 18-item model. There were high correlations among the 18 items. The internal consistency reliability was robust, with no floor/ceiling effects. These results represented equivalence and consistency among the responses to items, suggesting that these items were homogenous in measuring Malaysian health literacy. The strong convergent and discriminant validity of the model makes the proposed 18 items a suitable short version of the health literacy instrument for Malaysia. Conclusions: The researchers propose the 18-item instrument to be named HLS-M-Q18. This short version instrument may be used in measuring health literacy in Malaysia as it achieved robust reliability, structural validity and construct validity that fulfilled goodness-of-fit criteria.