bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics Signatures of Computed Tomography Imaging for Predicting Resection Margin Status in Pancreatic Head Adenocarcinoma
Authors: Liu Jinheng , Liu Xubao , Qiu Jiajun , Wang Yanting , Huang Wei , Ke Nengwen 
Published: August 2020

Abstract
Background: To identify preoperative computed tomography radiomics texture features which correlate with resection margin status and prognosis in resected pancreatic head adenocarcinoma. Methods: Improved prognostication methods utilizing novel non-invasive radiomic techniques may accurately predict resection margin status preoperatively. In an ongoing concerning pancreatic head adenocarcinoma, the venous enhanced CT images of 86 patients who underwent pancreaticoduodenectomy were selected, and the resection margin (>1 mm or ≤1 mm) was identified by pathological examination. Three regions of interests (ROIs) were then taken from superior to inferior facing the superior mesenteric vein and artery. Subsequent Laplacian-Dirichlet based texture analysis methods extracting algorithm flows of texture features within ROIs were analyzed and assessed in relation to patient prognosis.Results: Patients with >1 mm resection margin had an overall improved survival compared to ≤1 mm (P < 0.05). Distance 1 and 2 of Gray level co-occurrence matrix, high Gray-level run emphasis of run-length matrix and average filter of wavelet transform (all P < 0.05) were correlated with resection margin status (Area under the curve was 0.784, sensitivity was 75% and specificity was 79%). The energy of wavelet transform, the measure of smoothness of histogram and the variance in 2 direction of Gabor transform are independent predictors of overall survival prognosis, independent of resection margin.Conclusions: Resection margin status (>1 mm vs ≤1 mm) is a key prognostic factor in pancreatic adenocarcinoma and CT radiomic analysis have the potential to predict resection margin status preoperatively, and the radiomic labels may improve selection neoadjucant therapy. Trial registration: Clinicaltrials.gov/ct2/show/NCT02928081.
CircRNA Expression Profile in Lung Cancer Complicated with Chronic Obstructive Pulmonary Disease Patients
Authors: Wen Fuqiang , Li Xiaoou , Shen Yongchun , Cheng Jiahan , Chen Jun , Yuan Zhicheng , Wang Tao , Chen Lei , Liu Lunxu 
Published: August 2020

Abstract
Background: Lung cancer complicated with chronic obstructive pulmonary disease (COPD) are major causes of mortality worldwide, and the incidence of lung cancer and COPD increasing significantly. Circular RNAs (circRNAs), have been reported to participate in various biological processes, whereas the role of circRNAs in lung cancer complicated with COPD remains unclear. We aims to identify differentially expressed circRNAs (DEcircRNAs) between lung cancer complicated with COPD and lung cancer without COPD. Method: The circRNAs expression profiles were identified using a high-throughput circRNA microarray in cancer adjacent tissues from 6 lung cancer without COPD patients and 8 lung cancer complicated with COPD patients. Bioinformatic analyses were conducted to identify the functions of DEcircRNAs. Result: A total of 115 up- and 128 down-regulated circRNAs were screened in lung cancer complicated with COPD patients compared with lung cancer without COPD patients. The myD88-dependent toll-like receptor signaling pathway and positive regulation of nitric oxide biosynthetic process ranked the top 2 enriched biological processes in Gene Ontology analysis. Signaling transduction and infectious diseases were the most significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways in both up- and down-regulated circRNAs. Compared with lung cancer without COPD, circRNAs are dysregulated in the adjacent tissues of lung cancer with COPD. Conclusion: The DEcircRNAs might act as potential targets for the diagnosis of lung cancer with COPD.
Enriching the Nutritive Value of Marigold (Tagetes Erecta L) Crop Residues as a Ruminant​ Feed by Lactic Acid​ During Ensilage
Authors: Hou Zhijiang , Liu Jianyong , Cai Ming , Liu Yanpei , Mu Lan , Gao Yuee , Wanapat Metha , Huang Bizhi 
Published: August 2020

Abstract
Background: Marigold (Tagetes erecta L) accounts for over half of the world's loose flower production, and marigold crop residues (MCR) are abundantly available and should be used as a forage. In this study, MCR from the last commercial flower pickings was ensilaged with lactic acid bacteria (LAB) and the shift in their volatile organic compounds (VOCs) profiles was monitored. Samples were collected at 6 different times during ensilage (3, 6, 9, 12, 15, 30 days) to determine and quantify the VOCs changes using a solid-phase microextraction (SPME) technique and gas chromatography – mass spectrometry (GC-MS). Results: After 30 days, the caryophyllene and piprocyone, which account for 14.67% and 12.17% of total VOCs, decreased by 32.86% and 9.62% respectively, alcohols increased from 2.8% to 8.13%, and the acetic acid content increased by 560%. Conclusion: The results reported in this study show that during ensilage, LAB influences type and levels of VOCs. These results have shed light on our understanding of how to improve marigold residue odor and to enhance terpene degradation by lactic acid bacteria fermentation.
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry
Authors: Chen Yanwen , Lear Travis , Evankovich John , Larsen Mads , Lin Bo , Alfaras Irene , Kennerdell Jason , Salminen Laura , Camarco Daniel , Lockwood Karina , Liu Jie , Myerburg Michael , McDyer John , Liu Yuan , Finkel Toren , Chen Bill 
Published: August 2020

Abstract
SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung epithelial cells through the cell surface receptor ACE2, a process dependent on host proteases including TMPRSS2. Here, we identified small molecules that can reduce surface expression of TMPRSS2 using a 2,700 FDA-approved or current clinical trial compounds. Among these, homoharringtonine and halofuginone appear the most potent agents, reducing endogenous TMPRSS2 expression at sub-micromolar concentrations. These effects appear to be mediated by a drug-induced alteration in TMPRSS2 protein stability. We further demonstrate that halofuginone modulates TMPRSS2 levels through proteasomal-mediated degradation that involves the E3 ubiquitin ligase component DDB1- and CUL4-associated factor 1 (DCAF1). Finally, cells exposed to homoharringtonine and halofuginone, at concentrations of drug known to be achievable in human plasma, demonstrated marked resistance to SARS-CoV-2 pseudoviral infection. Given the safety and pharmacokinetic data already available for the compounds identified in our screen, these results should help expedite the rational design of human clinical trials designed to combat COVID-19 infection.
Trachoma in Sudan: Case series from Two Eye Care Hospitals and a Review of the Literature
Authors: Hassan Rawan Sharaf Eldein Elamein , Aabdeen Mohamed Abdulmonem Salih , Hassan Razan Sharaf Eldein Elamein , Mohamed Sagad Omer Obeid , Saad Fadwa Mohammed , Mohamed Haidar AbuAhmed 
Published: August 2020

Abstract
Background

Trachoma is a common infectious cause of blindness worldwide. Although it has largely now disappeared from developed countries, it is still endemic in many developing countries. We aimed to highlight clinical stages and common related socio-demographic and household characteristics among patients with trachoma in Sudan.
Methods

A hospital-based case series descriptive study was conducted at Makah Eye Complex and Abdalfadeel-Almaz hospital in Khartoum, Sudan. We included all Trachoma patients from all age groups attending the two eye care hospitals in the period from 1st to 31st March 2015. Data was collected through clinical examination, hospital records, and face to face interview using a structured questionnaire, Also, we conducted a review of the literature to highlights the epidemiological aspect of trachoma in Sudan, using the databases of MEDLINE (PubMed) and Google Scholar.
Results

In this case series, we identified 125 patients with trachoma in the study period. Most of them were aged more than 50 years old (78.4%). Half of the participants (56%) were positive for active trachoma, 40.8% of them were having Trachomatous Trichiasis (TT), and 56% of them have Trachoma Follicles (TF). Majority of the patients have low socioeconomic status and poor personal and environmental hygiene (88%), (44%) and (74.4%), respectively.
Conclusion

Low socioeconomic status and poor personal and environmental hygiene are common socio-demographic and household characteristics among patients with trachoma. Despite the progress that has been made towards disease elimination, trachoma is still a public health problem in Sudan. Our review highlights the magnitude of trachoma and the progress towards its elimination in Sudan.
WITHDRAWN: Treatment of Noninfectious Corneal Disorders With Plasma Rich in Growth Factors and ReGenerating Agent Matrix
Authors: Sanchez-Avila Ronald Mauricio , Uribe-Badillo Edmar , Gonzalez Carlos Fernandez-Vega , Muruzabal Francisco , Corcuera Borja De la Sen , Baamonde Begoña , Quiros Luis Manuel , Anitua Eduardo , Merayo-Lloves Jesús 
Published: August 2020

Abstract
Background: To provide the efficacy and safety of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers.Methods: This retrospective study included patients from Fernandez-Vega University Institute between 2010 and 2019, with noninfectious corneal ulcers and no response to standard treatments. RGTA treatment was firstly applied (1 drop every two days), but if ulcer closure was not achieved, PRGF eye drops treatment was added (4 times/day). The time to reach the ulcer closure; the Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), Visual Analog Scale (VAS, in frequency and severity of symptoms), and Ocular Surface Disease Index (OSDI) were evaluated. The presence of adverse events along the follow-up period was also reported. Results: Seventy-four patients (79 eyes) were included in the study, forty-six eyes (62.2%) were women, and the mean age was 56.8 ± 17.3 years. The neurotrophic corneal ulcer was the most frequent disorder found in the patients of the study (n = 27, 34.2%), mainly due to the herpes virus (n = 15, 19.0%). The mean time of PRGF eye drops treatment associated with RGTA matrix was 4.2 ± 2.2 (1.5 -9.0) months, and the follow-up period was 44.9 ± 31.5 months. The ulcer closure was achieved in 76 eyes (96.2%). BCVA, VAS and OSDI improved significantly from the baseline (p<0.001), while IOP remained unchanged (p=0.665). No adverse events were recorded. Conclusions: The use of RGTA and PRGF in noninfectious ulcers was effective and safe, and it could be a therapeutic alternative for this type of corneal diseases.
Chronotype and its association with lifestyle, health-related quality of life and academic performance among Japanese nursing students: A cross-sectional study
Authors: Kayaba Momoko , Matsushita Toshiko , Katayama Noriko , Inoue Yuichi , Sasai-Sakuma Taeko 
Published: August 2020

Abstract
Background: Generally, nursing university students struggle with academic work, that consequently bring about delayed bed time, insufficient sleep and worsened daytime functioning. The purpose of the present study is to clarify chronotype and its association with lifestyle, health-related quality of life and academic performance among nursing students.Methods: Self-reported questionnaires were distributed to undergraduate nursing students at six universities. Chronotype was assessed using the morningness-eveningness questionnaire. The generalized linear mixed effect model was utilized to identify the related factors with evening type among female nursing students (n = 447).Results: About 18% of Japanese female nursing students were identified as evening type. Evening type was associated with living alone, part-time job and club activity. Sleep duration on weekdays was shorter, meal time duration was the shortest, and the percentages of students who skipped meals and those who gained body weight were higher in the evening type than in the morning type and intermediate type. Mental health-related quality of life was lower in the intermediate type and evening type than in the morning type, while there was no difference in physical health-related quality of life among chronotype groups. The percentages of the nursing students who have experienced absence, tardiness, falling asleep during class and/or interference with academic achievement were higher in the evening type than in other chronotypes.Conclusions: Education of sleep hygiene and a healthy lifestyle to prevent late sleep-wake rhythm would contribute to improve nursing students’ health-related quality of life / academic performance.
Latency Optimization for D2D-Enabled Parallel Mobile Edge Computing in Cellular Networks
Authors: Ran Liang , Cai Yan , Zhang Jun , Zhu Hongbo 
Published: August 2020

Abstract
Edge offloading, including offloading to edge base stations (BS) via cellular links and to idle mobile users (MUs) via device-to-device (D2D) links, has played a vital role in achieving ultra-low latency characteristics in 5G wireless networks. This paper studies an offloading method of parallel communication and computation to minimize the delay in multi-user systems. Three different scenarios are explored, i.e., full offloading, partial offloading, and D2D-enabled partial offloading. In the full offloading scenario, we find a serving order for the MUs. Then, we jointly optimize the serving order and task segment in the partial offloading scenario. For the D2D-enabled partial offloading scenario, we decompose the problem into two subproblems and then find the optimal solution based on the results of the two subproblems. Finally, the simulation results demonstrate that the offloading method of parallel communication and computing can significantly reduce the system delay, and the D2D-enabled partial offloading can further reduce the latency.
miR-335-5p Suppresses Gastric Cancer Progression by Targeting MAPK10
Authors: Gao Yi , Wang Yanfeng , Wang Xiaofei , Zhao Changan , Wang Fenghui , Du Juan , Zhang Huahua , Shi Haiyan , Feng Yun , Li Dan , Yan Jing , Yao Yan , Hu Weihong , Ding Ruxin , Zhang Mengjie , Wang Lumin , Huang Chen , Zhang Jing 
Published: August 2020

Abstract
Background: In recent years, many microRNAs(miRNAs) involved in cancer progression. The aberrant expression of miR-335-5p in tumorigenesis has been demonstrated. The present study aimed to investigate the molecular mechanisms underlying miR-335-5p- regulated MAPK10 expression in human gastric cancer（GC）.Methods: The quantitative real-time PCR was used to study the level of miR-335-5p expression in gastric cancer cell lines and tissues. Subsequently, the MTT and cloning formation assays were used to detect cell proliferation, while transwell and wound-healing assays were used to identify invasion and migration of the gastric cancer cells. The correlation between the miR-335-5p and the cell cycle-related target gene mitogen‑activated protein kinase 10 (MAPK10) in gastric cancer was analyzed based on the website. In addition, the target gene of miR-335-5p was detected by luciferase reporter assay, qRT-PCR, and western blotting.Results: The miR-335-5p level was down-regulated in GC tissues and cell lines. Furthermore, miR-335-5p inhibited proliferation, migration of gastric cancer cells, and induced apoptosis. During the G1/S phase, miR-335-5p arrested the cycle of gastric cancer cells in vitro. The correlation between the miR-335-5p and the cell cycle-related target gene MAPK10 in GC was analyzed, MAPK10 was directly targeted by the miR-335-5p.Conclusion: These data suggested that miR-335-5p acts as a tumor suppressor, and go through the MAPK10 to inhibit the GC progression.
The human hippocampus and its subfield volume across age, sex and APOE e4 status
Authors: Veldsman Michele , Nobis Lisa , Almagro Fidel Alfaro , Smith Stephen , Manohar Sanjay , Husain Masud 
Published: August 2020

Abstract
Female sex, age and carriage of the APOE e4 allele are the greatest risk factors for sporadic Alzheimer's disease (AD). The hippocampus has a selective vulnerability to atrophy in ageing that may be accelerated in AD, including in those with increased genetic risk of AD. Within the hippocampal complex, subfields represent cytoarchitectonic and connectivity based divisions. The change in global hippocampal and subfield volume associated with sex, age and APOE e4 status in healthy ageing have not yet been established despite their potential to provide a sensitive biomarker of future vulnerability to AD. Here, we examined non-linear age, sex and APOE effects, and their interactions, on hippocampal and subfield volumes across several decades spanning mid-life to old age in 36 653 healthy ageing individuals. Hippocampal volume showed a marked reduction in APOE e4/e4 female carriers after age 65. Volume was lower in homozygous e4 individuals in specific subfields including the presubiculum, subiculum head, CA1 body, CA3 head and CA4. The findings demonstrate that in healthy ageing, two factors - female sex and APOE e4 status - confer selective vulnerability of specific hippocampal subfields to volume loss.
Salvage Surgery for Stage IVa Thymic Carcinoma Combined with Aortic Arch Resection, A Case Report
Authors: Yamato Hiroyuki , Funaki Soichiro , Shimamura Kazuo , Kin Keiwa , Kuratani Toru , Sawa Yoshiki , Shintani Yasushi 
Published: August 2020

Abstract
BackgroundAlthough complete surgical resection of thymic carcinoma is a prognostic factor, extended surgery combined with a major blood vessel procedure remains controversial because of the increased risk of mortality. We report a case of Stage IVa thymic carcinoma successfully resected with a pneumonectomy along with aortic arch replacement after chemotherapy. Case presentationA 45-year-old male was diagnosed with thymic carcinoma invasion to the aortic arch and left pulmonary artery. Malignant pericardial effusion was also noted, though disappeared after chemotherapy, thus surgical options were considered. A radical resection procedure including left pneumonectomy, aortic arch replacement with total rerouting of the supra-arch vessels, and right pulmonary artery plication was performed. The postoperative course was uneventful and the patient has been disease-free for 3 years.ConclusionExtended salvage surgery might be a valuable option for advanced thymic carcinoma.
Evaluation of learning environment among Nursing undergraduates in state universities, Sri Lanka
Authors: Jayaweera Patalee , Thilakarathne Abisheka , Ratnayaka Madushanka , Shashikala Tharangi , Arachchige Rushani , Galgamuwa Lahiru Sandaruwan , Karunathilaka Nimantha , Amarasekara Thamara 
Published: August 2020

Abstract
Background: The learning environment is a vital part of the undergraduate curriculum which enable to deliver quality education in the stipulated time. However, the level of the learning environment is highly context bounded. Therefore, the study aimed to evaluate the learning environment among BSc. Nursing undergraduates in Sri Lankan state universities.Methods: A descriptive cross sectional study was conducted among 161 final year BSc. Nursing undergraduates in six state universities. Socio demographic characteristics were collected using a self-administered questionnaire. The Dundee Ready Educational Environment Measure (DREEM) questionnaire was used to evaluate the learning environment in Perception of learning (SPL), Perceptions of teaching (SPT), Academic self-perceptions (SASP), Perceptions of the atmosphere (SPA) and Social self-perceptions (SSP). One way Analysis of Variance (ANOVA) and t test were used to determine the difference in the subscales and the overall scale.Results: The mean age of the students was 24.9 ± 0.9 years. Student’s Perception of learning showed the highest mean score of 31.1 ± 3.9 while the social self-perception showed the lowest score (mean 16.4 ± 3.1). A significant group effect was observed in SPL and SPT subdomains among state universities while no significant group effect was observed in other subdomains. Furthermore, participating in extracurricular activities, travelling time to the faculty and gender were observed as associated factors for learning environment among BSc. Nursing undergraduates in state universities.Conclusions: Although the overall learning environment was within more positive, none of the university reaches to the excellent category. Therefore, remedial actions need to be taken to improve the learning environment in future.
Discovery of exolytic heparinases and their catalytic mechanism and potential application
Authors: Zhang Qingdong , Cao Hai-Yan , Wei Lin , Lu Danrong , Du Min , Yuan Min , Shi Deling , Chen Xiangxue , Wang Peng , Chen Xiu-Lan , Chi Lianli , Zhang Yu-Zhong , Li fuchuan 
Published: August 2020

Abstract
Heparinases are critical tools for the studies of highly heterogeneous heparin (HP)/heparan sulfate (HS). However, the exolytic heparinases urgently needed for the sequencing of HP/HS chains are seemingly inaccessible. Herein, a type of exolytic heparinases (exoHepases) was identified from the genomes of different bacteria. These exoHepases share almost no homology with known Hepases and prefer to digest HP rather than HS chains by sequentially releasing unsaturated disaccharides from their reducing ends. The structural study of an exoHepase (exoHep) shows that an N-terminal conserved DUF4962 superfamily domain is essential to the exolytic activity of these exoHepases, which is involved in the formation of a unique L-shaped catalytic cavity controlling the sequential digestion of substrates through electrostatic interactions. Further, several HP octasaccharides were preliminarily sequenced by using exoHep. Overall, this study fills the research gap of exoHepases and provides urgently needed tools for the structural and functional studies of HP/HS chains.
Identification of stable alloy with giant magnetization via machine learning based autonomous materials search
Authors: Iwasaki Yuma , Sawada Ryohto , Saitoh Eiji , Ishida Masahiko 
Published: August 2020

Abstract
Discovery of new magnets with high magnetization has always been important in human history because it has given birth to powerful motors and memory devices. Currently, the binary alloy Fe3Co1 exhibits the largest magnetization of any stable alloys explained by the Slater-Pauling rule. A multi-element alloy system has been expected to include an alloy with magnetization beyond that of Fe3Co1, but it has been difficult to identify appropriate elements and compositions because of combinatorial explosion in the multi-element system. In this work, we found a new alloy with giant magnetization beyond that of Fe3Co1 via an autonomous materials search system combining machine learning and ab-initio calculation. After autonomous/automated exploration in the large material space of multi-element alloy for six weeks, the system unexpectedly indicated that Ir and/or Pt impurities would enhance the magnetization of FeCo alloys. To confirm this experimentally, we comprehensively synthesized FexCoyIr1-x-y and FexCoyPt1-x-y alloys and found that some of them have magnetization beyond that of Fe3Co1.