bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parents’ satisfaction on dental care of Dutch children with Autism Spectrum Disorder
Authors: Kind L. S. , Aartman I. H. A. , van Gemert-Schriks M. C. M. , Bonifacio C. C. 
Published: December 2020

AbstractPurposeTo assess if Dutch children with Autism Spectrum Disorder (ASD) regularly visit a dentist and to evaluate parent’s satisfaction on the care provided.MethodsParents of ASD children (2–18 years) were invited to fill out a survey. The survey consisted of questions regarding ASD severity, frequency of dental visits, history of dental pain, type of dental practice and parents’ satisfaction. Results were analysed using Chi square and Mann–WhitneyUtests (α = 5%).ResultsOf the 246 returned questionnaires, 19 were excluded (incomplete or unconfirmed ASD diagnosis). All children visited a dentist at least once and 5% of them had their last visit more than 12 months ago. According to parents, 15% of the children did not receive the needed care when they had toothache and 21% of the parents were unsatisfied with the current dental care provided. No difference was found between satisfied and unsatisfied parents in type of dental practice visited (p > 0.05). The children of unsatisfied parents reported more often pain during the last year (p = 0.013) and had a more severe type of ASD (p = 0.016).ConclusionsThe majority of Dutch ASD children investigated regularly visit a dentist and 21% of the parents is unsatisfied with the dental care provided.
Competition among coalitions in a cournot industry: a validation of the porter hypothesis
Authors: Lambertini Luca , Pignataro Giuseppe , Tampieri Alessandro 
Published: December 2020

AbstractWe determine the emergence of the Porter hypothesis in a large oligopoly setting where the industry-wide adoption of green technologies is endogenously determined as a result of competition among coalitions. We examine a framework where firms decide whether to be “brown” or “green” and compete in quantities. We find that the Porter hypothesis may emerge as a market configuration with all green firms spurred by environmental regulation, even if consumers are not environmentally concerned. We also single out the necessary and sufficient conditions under which the green grand coalition is socially optimal and therefore yields a win–win outcome. Then, we show that, if the environmental externality is steep enough, the tax rate maximising welfare in the initial industry configuration is a driver of the win–win solution. Finally, the analysis is extended in several directions.
Update on the neurodevelopmental theory of depression: is there any ‘unconscious code’?
Authors: Gałecka Małgorzata , Bliźniewska-Kowalska Katarzyna , Maes Michael , Su Kuan-Pin , Gałecki Piotr 
Published: December 2020

AbstractDepression is currently one of the most common psychiatric disorders and the number of patients receiving antidepressant treatment is increasing every year. Therefore, it is essential to understand the underlying mechanisms that are associated with higher prevalence of depression. The main component leading to the change in functioning, in the form of apathy, anhedonia, lack of motivation and sleep disturbances, is stress. This is the factor that in recent decades—due to the civilization speed, dynamic technological development as well as competitiveness and competition in relationships—significantly affects the psychophysical condition, which results in an increase in the prevalence of civilization diseases, including depression. To understand the mechanism of susceptibility to this disease, one should consider the significant role of the interaction between immune and nervous systems. Their joint development from the moment of conception is a matrix of later predispositions, both associated with the mobilization of the proinflammatory pathways (TNFα, IL-1β, IL-6) and associated with psychological coping with stress. Such an early development period is associated with epigenetic processes that are strongly marked in prenatal development up to 1 year of age and determinate the characteristic phenotype for various forms of pathology, including depression. Regarding the inflammatory hypothesis of depression, interleukin 17 (IL-17), among other proinflammatory cytokines, might play an important role in the development of depressive disorders. It is secreted by Th17 cells, crossed the placental barrier and acts on the brain structures of the fetus by increasing IL-17 receptor levels and affecting the intensity of its signaling in the brain.
Using Broadband Radio Noise From Power‐Lines to Map and Track Dense Es Structures
Authors: Obenberger K. S. , Dowell J. , Fallen C. T. , Holmes J. M. , Taylor G. B. , Varghese S. S. 
Published: December 2020

AbstractWe present passive observations of midlatitude sporadic E (Es) structures in the 30–50 MHz range using the long wavelength array telescopes in New Mexico. Spectral and temporal analysis of the structures reveals that some of the emissions can be characterized by broadband, spark‐like radiation occurring at a repetition frequency of 60 Hz. The azimuthal distribution indicates that the brightest emissions come from the directions of several large metropolitan centers with distances ranging from 700 to 1,250 km from the telescopes. This implies that the source is unintended human‐made noise, originating from devices connected to 60 Hz alternating current power. The geometry of our observations rule out coherent scatter from field‐aligned irregularities, and indicate that the unintended noise must undergo a specular reflection off of over‐dense plasma distributed approximately parallel to Earth's surface. On certain occasions the reflections are seen at such high frequencies and high elevation angles that the local plasma frequency must be above 30 MHz. During both day and night Es conditions, the dense structures are observed to be arranged in propagating fronts, and travel at speeds of 70–100 m/s. We also present observations that reveal quasi‐periodic amplitude oscillations with frequencies consistent with atmospheric gravity waves and acoustic waves.
Fecal short chain fatty acids in children living on farms and a link between valeric acid and protection from eczema
Authors: Gio-Batta Monica , Sjöberg Fei , Jonsson Karin , Barman Malin , Lundell Anna-Carin , Adlerberth Ingegerd , Hesselmar Bill , Sandberg Ann-Sofie , Wold Agnes E. 
Published: December 2020

AbstractChildren growing up on farms have low rates of allergy, but the mechanism for this protective effect has not been fully elucidated. Short chain fatty acids (SCFAs) produced by the gut microbiota may play a role in protection from allergy. We measured fecal SCFA levels in samples collected from 28 farming and 37 control children over the first 3 years of life using gas chromatography. Data on diet and other host factors were recorded and allergy was diagnosed at 8 years of age. Among all children, median propionic and butyric acid concentration increased over the first 3 years, and longer SCFAs typically appeared by 1 year of age. Farm children had higher levels of iso-butyric, iso-valeric and valeric acid at 3 years of age than rural controls. In addition, children with elder siblings had higher levels of valeric acid at 3 years of age, and dietary factors also affected SCFA pattern. High levels of valeric acid at 3 years of age were associated with low rate of eczema at 8 years of age. The fecal SCFA pattern in farm children suggests a more rapid maturation of the gut microbiota. Valeric acid or associated microbes may have protective potential against eczema.
A method for studying pico to microsecond time-resolved core-level spectroscopy used to investigate electron dynamics in quantum dots
Authors: Sloboda Tamara , Svanström Sebastian , Johansson Fredrik O. L. , Andruszkiewicz Aneta , Zhang Xiaoliang , Giangrisostomi Erika , Ovsyannikov Ruslan , Föhlisch Alexander , Svensson Svante , Mårtensson Nils , Johansson Erik M. J. , Lindblad Andreas , Rensmo Håkan , Cappel Ute B. 
Published: December 2020

AbstractTime-resolved photoelectron spectroscopy can give insights into carrier dynamics and offers the possibility of element and site-specific information through the measurements of core levels. In this paper, we demonstrate that this method can access electrons dynamics in PbS quantum dots over a wide time window spanning from pico- to microseconds in a single experiment carried out at the synchrotron facility BESSY II. The method is sensitive to small changes in core level positions. Fast measurements at low pump fluences are enabled by the use of a pump laser at a lower repetition frequency than the repetition frequency of the X-ray pulses used to probe the core level electrons: Through the use of a time-resolved spectrometer, time-dependent analysis of data from all synchrotron pulses is possible. Furthermore, by picosecond control of the pump laser arrival at the sample relative to the X-ray pulses, a time-resolution limited only by the length of the X-ray pulses is achieved. Using this method, we studied the charge dynamics in thin film samples of PbS quantum dots on n-type MgZnO substrates through time-resolved measurements of the Pb 5d core level. We found a time-resolved core level shift, which we could assign to electron injection and charge accumulation at the MgZnO/PbS quantum dots interface. This assignment was confirmed through the measurement of PbS films with different thicknesses. Our results therefore give insight into the magnitude of the photovoltage generated specifically at the MgZnO/PbS interface and into the timescale of charge transport and electron injection, as well as into the timescale of charge recombination at this interface. It is a unique feature of our method that the timescale of both these processes can be accessed in a single experiment and investigated for a specific interface.
A model to rate strategies for managing disease due to COVID-19 infection
Authors: Wang Shiyan , Ramkrishna Doraiswami 
Published: December 2020

AbstractConsidering looming fatality and economic recession, effective policy making based on ongoing COVID-19 pandemic is an urgent and standing issue. Numerous issues for controlling infection have arisen from public discussion led by medical professionals. Yet understanding of these factors has been necessarily qualitative and control measures to correct unfavorable trends specific to an infection area have been lacking. The logical implement for control is a large scale stochastic model with countless parameters lacking robustness and requiring enormous data. This paper presents a remedy for this vexing problem by proposing an alternative approach. Machine learning has come to play a widely circulated role in the study of complex data in recent times. We demonstrate that when machine learning is employed together with the mechanistic framework of a mathematical model, there can be a considerably enhanced understanding of complex systems. A mathematical model describing the viral infection dynamics reveals two transmissibility parameters influenced by the management strategies in the area for the control of the current pandemic. Both parameters readily yield the peak infection rate and means for flattening the curve, which is correlated to different management strategies by employing machine learning, enabling comparison of different strategies and suggesting timely alterations. Treatment of population data with the model shows that restricted non-essential business closure, school closing and strictures on mass gathering influence the spread of infection. While a rational strategy for initiation of an economic reboot would call for a wider perspective of the local economics, the model can speculate on its timing based on the status of the infection as reflected by its potential for an unacceptably renewed viral onslaught.
Differences of the tumour cell glycocalyx affect binding of capsaicin-loaded chitosan nanocapsules
Authors: von Palubitzki Lydia , Wang Yuanyuan , Hoffmann Stefan , Vidal-y-Sy Sabine , Zobiak Bernd , Failla Antonio V. , Schmage Petra , John Axel , Osorio-Madrazo Anayancy , Bauer Alexander T. , Schneider Stefan W. , Goycoolea Francisco M. , Gorzelanny Christian 
Published: December 2020

AbstractThe glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer cells control the binding and uptake of nanoparticles. In the present study, exome sequencing data of cancer patients and analysis of distinct melanoma and bladder cancer cell lines suggested differences in cancer cell-exposed glycocalyx components such as heparan sulphate. Our data indicate that glycocalyx differences affected the binding of cationic chitosan nanocapsules (Chi-NCs). The pronounced glycocalyx of bladder cancer cells enhanced the internalisation of nanoencapsulated capsaicin. Consequently, capsaicin induced apoptosis in the cancer cells, but not in the less glycosylated benign urothelial cells. Moreover, we measured counterion condensation on highly negatively charged heparan sulphate chains. Counterion condensation triggered a cooperative binding of Chi-NCs, characterised by a weak binding rate at low Chi-NC doses and a strongly increased binding rate at high Chi-NC concentrations. Our results indicate that the glycocalyx of tumour cells controls the binding and biological activity of nanoparticles. This has to be considered for the design of tumour cell directed nanocarriers to improve the delivery of cytotoxic drugs. Differential nanoparticle binding may also be useful to discriminate tumour cells from healthy cells.
Reliance on model-based and model-free control in obesity
Authors: Janssen Lieneke K. , Mahner Florian P. , Schlagenhauf Florian , Deserno Lorenz , Horstmann Annette 
Published: December 2020

AbstractConsuming more energy than is expended may reflect a failure of control over eating behaviour in obesity. Behavioural control arises from a balance between two dissociable strategies of reinforcement learning: model-free and model-based. We hypothesized that weight status relates to an imbalance in reliance on model-based and model-free control, and that it may do so in a linear or quadratic manner. To test this, 90 healthy participants in a wide BMI range [normal-weight (n = 31), overweight (n = 29), obese (n = 30)] performed a sequential decision-making task. The primary analysis indicated that obese participants relied less on model-based control than overweight and normal-weight participants, with no difference between overweight and normal-weight participants. In line, secondary continuous analyses revealed a negative linear, but not quadratic, relationship between BMI and model-based control. Computational modelling of choice behaviour suggested that a mixture of both strategies was shifted towards less model-based control in obese participants. Our findings suggest that obesity may indeed be related to an imbalance in behavioural control as expressed in a phenotype of less model-based control potentially resulting from enhanced reliance on model-free computations.
Maternal separation in rats induces neurobiological and behavioral changes on the maternal side
Authors: Bölükbas Ibrahim , Mundorf Annakarina , Freund Nadja 
Published: December 2020

AbstractThe time after parturition is a sensitive period for mothers where they are prone to develop psychopathological symptoms. Studies investigating dams after separation from their pups (maternal separation, MS) showed that MS induces alterations similar to postpartum depression. This study aims to give further details on affected behavior and neurobiology of dams after MS. MS in rats from postnatal day 2–20 over four hours daily was performed. Upon reunion, maternal behavior, and ultrasonic vocalization (USV) of dams were measured. On the day of weaning, dams were tested for anxiety-like behavior in the elevated-plus-maze and marble burying test. Then Morc1 mRNA in the medial prefrontal cortex and Nr3c1 encoding the glucocorticoid receptor mRNA in the hippocampus were measured using real-time PCR to examine possible neurobiological correlates in psychopathology and social behavior. GABA and glutamate serum levels were analyzed by high-performance liquid chromatography as peripheral markers for stress-induced psychopathology. MS in dams increased maternal care towards pups even though both groups show high levels of maternal behavior even in late lactation. Furthermore, the emission of 50-kHz and 22-kHz USVs increased significantly. No differences in anxiety-like behavior were detected. MS further reduced Morc1 but not Nr3c1 expression. Serum GABA but not glutamate levels were significantly increased in separated dams. This study reinforces the benefit of investigating dams after MS for studying postpartum stress. Subclinical markers mainly connected to depression, namely Morc1 and GABA, proved to be useful allowing for earlier detection of symptoms of critical postpartum stress.
Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
Authors: Rendo Veronica , Kundu Snehangshu , Rameika Natallia , Ljungström Viktor , Svensson Richard , Palin Kimmo , Aaltonen Lauri , Stoimenov Ivaylo , Sjöblom Tobias 
Published: December 2020

AbstractTherapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH) at 8p22. These tumors were sensitive to treatment with a cytotoxic substrate of NAT2 (6-(4-aminophenyl)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine, APA), and pointed to NAT2 loss being a therapeutically exploitable vulnerability of CRC tumors. To better estimate the total number of treatable CRC patients, we here determined whether tumor cells retaining also other NAT2 low activity variants after LOH respond to APA treatment. The prevalent low activity alleles NAT2*5 and NAT2*14, but not NAT2*7, were found to be low metabolizers with high sensitivity to APA. By analysis of two different CRC patient cohorts, we detected heterozygosity for NAT2 alleles targetable by APA, along with allelic imbalances pointing to LOH, in ~ 24% of tumors. Finally, to haplotype the NAT2 locus in tumor and patient-matched normal samples in a clinical setting, we develop and demonstrate a long-read sequencing based assay. In total, > 79.000 CRC patients per year fulfil genetic criteria for high sensitivity to a NAT2 LOH therapy and their eligibility can be assessed by clinical sequencing.
Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus
Authors: Randrianarisoa Elko , Lehn-Stefan Angela , Hieronimus Anja , Wagner Robert , Maucher Jakob , Rittig Kilian , Balletshofer Bernd , Birkenfeld Andreas L. , Peter Andreas , Stefan Norbert , Häring Hans-Ulrich , Fritsche Andreas , Heni Martin 
Published: December 2020

AbstractHyperglycemia and insulin resistance contribute to vascular damage and are regulated by different pathophysiological processes. The aim of the study was to systematically investigate the relative contributions of multiple fasting state- and oral glucose tolerance test (oGTT)-derived glycemic traits to carotid intima-media thickness (cIMT), a surrogate parameter of subclinical atherosclerosis, in individuals with increased risk for type 2 diabetes mellitus (T2D). 667 volunteers (417 women and 250 men, mean age 44.1 years), who were free of cardiovascular disease (CVD), were included in this cross-sectional study. Glucose tolerance, insulin sensitivity, insulin secretion and insulin clearance were assessed by frequently sampled 75 g oGTT. CIMT was measured by high-resolution ultrasound. Insulin clearance was associated with cIMT in univariate analysis (ßst = − 0.17, p < 0.0001) and in a stepwise regression analysis on 15 variables possibly affecting cIMT, age (r2 = 0.3923, p < 0.0001), insulin clearance (r2 = 0.4564, p < 0.0001), systolic blood pressure (r2 = 0.4733, p < 0.0001), body mass index (BMI) (r2 = 0.4804, p = 0.002), gender (r2 = 0.4831, p = 0.013), and fasting insulin clearance (r2 = 0.4857, p = 0.030) turned out to be significant determinants of cIMT. In a cross-validated model resulting from this analysis, insulin clearance was found to be an independent determinant of cIMT (ßst = − 0.16, p < 0.0001) even after adjusting for traditional CVD risk factors. Reduced insulin clearance may be an early marker of damage on the vasculature, independent of classical CVD risk factors. Reduced insulin clearance should be considered with regard to vascular insulin resistance.
The construction of a novel luminescent lanthanide framework for the selective sensing of Cu2+ and 4-nitrophenol in water
Authors: Lin Zeng-Gang , Song Fu-Qiang , Wang Hui , Song Xue-Qin , Yu Xin-Xin , Liu Wei-sheng 
Published: December 2020

Two water stable Ln-MOFs that take the (4,4,4)-connected nets with unprecedented topology symbol of {42·6·83}2{42·62·82}{42·84} were developed for sensing Cu2+ and 4-NP in aqueous media with high selectivity and sensitivity.
Optical phase‐sensitive amplification of higher‐order QAM signal with single Mach–Zehnder amplitude modulator
Authors: Shimizu S. , Kobayashi T. , Kazama T. , Umeki T. , Enbutsu K. , Kasahara R. , Miyamoto Y. 
Published: December 2020

AbstractAn optical phase‐sensitive amplifier (PSA) has the potential of low‐noise optical amplification. A frequency non‐degenerate PSA (ND‐PSA) can amplify arbitrary modulation formats including higher‐order QAM. The ND‐PSA requires a co‐propagating phase conjugated light (idler light) that has been conventionally created with an optical phase conjugator at the transmitter side. We propose a transmitter configuration using simultaneous signal generation of both a signal and its idler by double‐sideband modulation for transmission systems with ND‐PSAs. The proposed scheme provides a simple configuration with a single Mach–Zehnder amplitude modulator without optically creating the idler light. We performed experiments using 16QAM, 32QAM, and probabilistically shaped 256QAM signals. As a result, a phase‐sensitive amplification with each modulation format was successfully demonstrated using the proposed transmitter configuration.
H.266/VVC fast intra prediction using Sobel edge features
Authors: Yang Shih‐Hsuan , Hsiao Sheng‐Jung 
Published: December 2020

AbstractVersatile video coding is the next‐generation video coding standard. Compared with the previous high efficiency video coding standard, versatile video coding reduces 30% or more bitrate but requires significantly higher encoding complexity. This Letter proposes a fast intra prediction algorithm for partition type selection and mode decision of versatile video coding. The Sobel operator is employed to extract the gradient intensity and edge direction of coding blocks. Early skip conditions for partition types are developed based on the dominant edge indicated by block gradients. The intra prediction modes are further restricted to the directions close to the edge orientation of a coding block. Experimental results indicate that the proposed method in the Intra‐only configuration saves 34.66% of the encoding time with a slight (0.61%) increase in Bjøntegaard delta bit rate, which achieves the best tradeoff between acceleration and quality among all the investigated methods.