bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biology and biotechnology of microbial pilus nanowires
Authors: Clark Morgen M , Reguera Gemma 
Published: October 2020

Abstract
Type IV pili (T4P) are bacterial appendages used for cell adhesion and surface motility. In metal-reducing bacteria in the genus Geobacter, they have the unique property of being conductive and essential to wire cells to extracellular electron acceptors and other cells within biofilms. These electroactive bacteria use a conserved pathway for biological assembly and disassembly of a short and aromatic dense peptide subunit (pilin). The polymerization of the pilins clusters aromatic residues optimally for charge transport and exposes ligands for metal immobilization and reduction. The simple design yet unique functionalities of conductive T4P afford opportunities for the scaled-up production of recombinant pilins and their in vitro assembly into electronic biomaterials of biotechnological interest. This review summarizes current knowledge of conductive T4P biogenesis and functions critical to actualize applications in bioelectronics, bioremediation, and nanotechnology.
Multi-scale mammal responses to agroforestry landscapes in the Brazilian Atlantic Forest: the conservation value of forest and traditional shade plantations
Authors: Ferreira Aluane Silva , Peres Carlos A. , Dodonov Pavel , Cassano Camila Righetto 
Published: October 2020

AbstractThe future of tropical forest biodiversity will largely depend on human-modified landscapes. We investigated how medium- to large-bodied mammals respond to factors at local (habitat type), intermediate (land use heterogeneity, forest cover and human population density) and large spatial scales (overall forest cover) in agroforestry landscapes. We surveyed mammals using camera traps in traditional cacao agroforests (cabrucas), intensified cacao agroforests, and forest remnants within two large Atlantic Forest landscapes of southern Bahia, Brazil, representing both high and low forest cover. At the local scale, habitat types differed in their potential to harbour mammal species, with forest remnants and cabrucas showing high conservation value, mainly under contexts of high forest cover, whereas intensified cacao agroforests contained less diversified species assemblages in both landscapes. At intermediate scales, species richness increased with increasing forest cover around forest remnants and intensified cacao agroforests, but the opposite was observed in cabrucas. The effects of human population density were ubiquitous but species-dependent. At the largest scale, species richness was higher in the most forested landscape, highlighting the imperative of maintaining forest remnants to retain forest-dwelling mammals in human-dominated landscapes. We claim that mammal conservation strategies require a multi-scale approach and that no single strategy is likely to maximize persistence of all species. Some species can routinely use traditional agroforests, and a large fraction of mammal diversity can be maintained even if high canopy-cover agroforestry dominates the landscape. Nevertheless, forest patches and highly forested landscapes are essential to ensure the persistence of forest-dwelling and game species.
Numerical Investigation of Remote Ignition in Shock Tubes
Authors: Lipkowicz Jonathan Timo , Nativel Damien , Cooper Sean , Wlokas Irenäus , Fikri Mustapha , Petersen Eric , Schulz Christof , Kempf Andreas Markus 
Published: October 2020

AbstractHighly resolved two- and three-dimensional computational fluid dynamics (CFD) simulations are presented for shock-tube experiments containing hydrogen/oxygen (H2/O2) mixtures, to investigate mechanisms leading to remote ignition. The results of the reactive cases are compared against experimental results from Meyer and Oppenheim (Proc Combust Inst 13(1): 1153–1164, 1971. 10.1016/s0082-0784(71)80112-1) and Hanson et al. (Combust Flame 160(9): 1550–1558, 2013. 10.1016/j.combustflame.2013.03.026). The results of the non-reactive case are compared against shock tube experiments, recently carried out in Duisburg and Texas. The computational domain covers the end-wall region of the shock tube and applies high order numerics featuring an all-speed approximate Riemann scheme, combined with a 5th order interpolation scheme. Direct chemistry is employed using detailed reaction mechanisms with 11 species and up to 40 reactions, on a grid with up to 2.2 billion cells. Additional two-dimensional simulations are performed for non-reactive conditions to validate the treatment of boundary-layer effects at the inlet of the computational domain. The computational domain covers a region at the end part of the shock tube. The ignition process is analyzed by fields of localized, expected ignition times. Instantaneous fields of temperature, pressure, entropy, and dissipation rate are presented to explain the flow dynamics, specifically in the case of a bifurcated reflected shock. In all cases regions with locally increased temperatures were observed, reducing the local ignition-delay time in areas away from the end wall significantly, thus compensating for the late compression by the reflected shock and therefore leading for first ignition at a remote location, i.e., away from the end wall where the ignition would occur under ideal conditions. In cases without a bifurcated reflected shock, the temperature increase results from shock attenuation. In cases with a bifurcated reflected shock, the formation of a second normal shock and shear near the slip line is found to be crucial for the remote ignition to take place. Overall, the two- and three-dimensional simulations were found to qualitatively explain the occurrence of remote ignition and to be quantitatively correct, implying that they include the correct physics.
Components of School-Based Interventions Stimulating Students’ Intrapersonal and Interpersonal Domains: A Meta-analysis
Authors: Mertens Esther , Deković Maja , Leijten Patty , Van Londen Monique , Reitz Ellen 
Published: October 2020

AbstractMany universal school-based interventions aim to stimulate students’ intrapersonal (e.g., self-esteem) and interpersonal (e.g., school climate) domains. To improve our understanding of why some of these interventions yield stronger effects than others, we identified intervention components that are related to stronger or weaker intervention effects. We systematically searched four databases (i.e., PsycINFO, PubMed, ERIC, CENTRAL) for controlled evaluations of universal school-based interventions. In total, 104 included studies (529 included effect sizes) reported on 99 unique interventions. Interventions showed small positive effects on the intrapersonal (d = 0.19) and interpersonal (d = 0.15) domains. Focusing on self-awareness and problem solving, using more active learning approaches, and using more extensive interventions predicted stronger intervention effects on aspects of both domains. In contrast, efforts to improve emotion regulation, assertiveness, cognitive coping, and using group discussions predicted weaker intervention effects. Furthermore, commonly implemented components were not necessarily related to stronger intervention effects and components that were related to stronger effects were not necessarily often implemented. Our findings highlight the need to carefully select components for inclusion in interventions.PROSPERO Registration Number: CRD42019137981.
Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants
Authors: Piltonen Marjo , Krokhotin Andrey , Parisien Marc , Bérubé Pierre , Djambazian Haig , Sladek Rob , Dokholyan Nikolay V. , Shabalina Svetlana A. , Diatchenko Luda 
Published: October 2020

AbstractThe opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, and nociceptin receptors that belong to the superfamily of 7-transmembrane spanning G protein-coupled receptors (GPCRs). The mu-opioid receptor is the main target for clinically used opioid analgesics, and its biology has been extensively studied. The N-terminally truncated 6TM receptors isoform produced through alternative splicing of theOPRM1gene displays unique signaling and analgesic properties, but it is unclear if other OPRs have the same ability. In this study, we have built a comprehensive map of alternative splicing events that produce 6TM receptor variants in all the OPRs and demonstrated their evolutionary conservation. We then obtained evidence for their translation through ribosomal footprint analysis. We discovered that N-terminally truncated 6TM GPCRs are rare in the human genome and OPRs are overrepresented in this group. Finally, we also observed a significant enrichment of 6TM GPCR genes among genes associated with pain, psychiatric disorders, and addiction. Understanding the biology of 6TM receptors and leveraging this knowledge for drug development should pave the way for novel therapies.
The Amsterdam Sexual Abuse Case: What Scars did it Leave? Long-Term Course of Psychological Problems for Children Who have been Sexually Abused at a Very Young Age, and their Parents
Authors: Tsang Vionna M. W. , Verlinden Eva , van Duin Esther M. , Twisk Jos W. R. , Brilleslijper-Kater Sonja N. , Gigengack Maj R. , Verhoeff Arnoud P. , Lindauer Ramón J. L. 
Published: October 2020

AbstractLongitudinal research of CSA in infancy and early childhood is scarce. The current study examined the long-term course of psychological outcomes (PTSD, dissociation and internalizing and externalizing behavioral problems) in children who were sexually abused in the early childhood. Additionally, we looked into the outcomes for their parents by assessing PTSD symptoms and negative emotional reactions towards the sexual abuse of their child. We examined the outcomes for five consecutive years in a sample of children (n = 45) who were sexually abused at a very young age (0–3) and their parents (n = 42), included in the Amsterdam Sexual Abuse Case-study. We found that outcomes following CSA in early childhood go beyond PTSD symptoms and can manifest in atypical symptoms such as behavioral problems. Parents experienced persistent PTSD in the years following CSA disclosure. CSA in very young children warrants long-term monitoring, as negative outcomes still present 8 years later.
Inter-model agreement on projected shifts in California hydroclimate characteristics critical to water management
Authors: Persad Geeta G. , Swain Daniel L. , Kouba Claire , Ortiz-Partida J. Pablo 
Published: October 2020

AbstractShifts away from the historical hydroclimate in populated regions can have dire consequences for water management. Regions like the state of California—where highly engineered, geographically interconnected, and inflexible water management systems are predicated on particular spatiotemporal patterns of water availability—are particularly vulnerable to hydroclimate shifts. However, much of the analysis of hydroclimate sensitivity to anthropogenic climate change has focused on gross metrics like annual mean precipitation, which is highly uncertain at the regional scale. This perceived uncertainty has deterred adaptation investments and quantitative integration of climate projection data into regional water management. Here, we assess projected future shifts in the state of California in a range of hydroclimate metrics critical to water management, using data from 10 statistically downscaled global climate model and two emissions scenarios currently used by the state. We find substantial inter-model agreement under both emissions scenarios—and > 80% inter-model agreement under the more severe climate change scenario—across metrics that collectively point toward an increasingly volatile, temporally concentrated, and extreme precipitation future for the state. We show, via hydrologic and operations modeling, that accounting for shifts in these more nuanced metrics reduces the projected reliability and sustainability of current water management practices to a greater degree than would be inferred from changes in total annual precipitation alone. These results highlight both the viability and critical importance of incorporating climate change projections quantitatively into water management decisions in California and other regions vulnerable to hydroclimate shifts, and underscore the need to develop integrated climate-hydrologic-operations models and decision-making protocols capable of accounting for all projected hydroclimate shifts.
Intentional and Performative Persuasion: The Linguistic Basis for Criminalizing the (Direct and Indirect) Encouragement of Terrorism
Authors: Macdonald Stuart , Lorenzo-Dus Nuria 
Published: October 2020

AbstractArticle 5 of the Council of Europe Convention on the Prevention of Terrorism requires member states to criminalise ‘public provocation to commit a terrorist offence’. In the U.K., the realisation of this obligation is found in the ‘Encouragement of terrorism’ offence contained in section 1 of the Terrorism Act 2006. As well as fulfilling the U.K.’s treaty obligation, this offence was intended to stop the spread of violent extremist ideology. Although the compatibility of this offence with the right to freedom of expression enshrined in Article 10 of the European Convention on Human Rights has been queried, both the domestic courts and the European Court of Human Rights have held that it complies with Article 10’s demands. So, instead of taking Article 10 as its starting point, this article draws instead on work from the field of linguistics: namely, speech act theory (SAT). By using insights from SAT, and by examining some of the linguistic strategies that may be used to encourage acts of terrorism, the article seeks to advance the legal understanding of the concept of encouragement. In particular, the article draws out two features of encouragement that have important implications for the appropriate boundaries of the encouragement of terrorism offence -encouragement is intentional and it is performative - and argues that, as currently drafted, the offence does not reflect the nature of encouragement as an intentional activity. The article concludes by drawing out from its analysis a series of proposed amendments that together address the rights-based concerns about the offence whilst maintaining its effectiveness as a counterterrorism tool.
Understanding Stigmatisation: Results of a Qualitative Formative Study with Adolescents and Adults in DR Congo
Authors: Hartog Kim , Peters Ruth M. H. , Jordans Mark J. D. 
Published: October 2020

AbstractWhile stigmatisation is universal, stigma research in low- and middle-income countries (LMIC) is limited. LMIC stigma research predominantly concerns health-related stigma, primarily regarding HIV/AIDS or mental illness from an adult perspective. While there are commonalities in stigmatisation, there are also contextual differences. The aim of this study in DR Congo (DRC), as a formative part in the development of a common stigma reduction intervention, was to gain insight into the commonalities and differences of stigma drivers (triggers of stigmatisation), facilitators (factors positively or negatively influencing stigmatisation), and manifestations (practices and experiences of stigmatisation) with regard to three populations: unmarried mothers, children formerly associated with armed forces and groups (CAAFAG), and an indigenous population. Group exercises, in which participants reacted to statements and substantiated their reactions, were held with the ‘general population’ (15 exercises, n = 70) and ‘populations experiencing stigma’ (10 exercises, n = 48). Data was transcribed and translated, and coded in Nvivo12. We conducted framework analysis. There were two drivers mentioned across the three populations: perceived danger was the most prominent driver, followed by perceived low value of the population experiencing stigma. There were five shared facilitators, with livelihood and personal benefit the most comparable across the populations. Connection to family or leaders received mixed reactions. If unmarried mothers and CAAFAG were perceived to have taken advice from the general population and changed their stereotyped behaviour this also featured as a facilitator. Stigma manifested itself for the three populations at family, community, leaders and services level, with participation restrictions, differential treatment, anticipated stigma and feelings of scapegoating. Stereotyping was common, with different stereotypes regarding the three populations. Although stigmatisation was persistent, positive interactions between the general population and populations experiencing stigma were shared as well. This study demonstrated utility of a health-related stigma and discrimination framework and a participatory exercise for understanding non-health related stigmatisation. Results are consistent with other studies regarding these populations in other contexts. This study identified commonalities between drivers, facilitators and manifestations—albeit with population-specific factors. Contextual information seems helpful in proposing strategy components for stigma reduction.
The leaky pipeline in research grant peer review and funding decisions: challenges and future directions
Authors: Sato Sayaka , Gygax Pascal Mark , Randall Julian , Schmid Mast Marianne 
Published: October 2020

AbstractThe growing literature on gender inequality in academia attests to the challenge that awaits female researchers during their academic careers. However, research has not yet conclusively resolved whether these biases persist during the peer review process of research grant funding and whether they impact respective funding decisions. Whereas many have argued for the existence of gender inequality in grant peer reviews and outcomes, others have demonstrated that gender equality is upheld during these processes. In the present paper, we illustrate how these opinions have come to such opposing conclusions and consider methodological and contextual factors that render these findings inconclusive. More specifically, we argue that a more comprehensive approach is needed to further the debate, encompassing individual and systemic biases as well as more global social barriers. We also argue that examining gender biases during the peer review process of research grant funding poses critical methodological challenges that deserve special attention. We conclude by providing directions for possible future research and more general considerations that may improve grant funding opportunities and career paths for female researchers.
Legal Imaginaries and the Anthropocene: ‘Of’ and ‘For’
Authors: Grear Anna 
Published: October 2020

AbstractThis reflection contrasts the dominant imaginary underlying ‘lawofthe Anthropocene’ with an imaginary reaching towards ‘law/sforthe Anthropocene’. It does so primarily by contrasting two imaginaries of human embodiment—law’s existing imaginary of quasi-disembodiment and an alternative imaginary of embodiment as co-woven with the lively incipiencies and tendencies of matter. It draws on ‘transcorporeality’ and ‘sympoiesis’ as inspiration for ‘sympoietic normativities’ as ways of co-living and co-organizing in the face of the catastrophic implications of the Anthropocene emergency.
GPU-accelerated image segmentation based on level sets and multiple texture features
Authors: Reska Daniel , Kretowski Marek 
Published: October 2020

AbstractIn this paper, we present a fast multi-stage image segmentation method that incorporates texture analysis into a level set-based active contour framework. This approach allows integrating multiple feature extraction methods and is not tied to any specific texture descriptors. Prior knowledge of the image patterns is also not required. The method starts with an initial feature extraction and selection, then performs a fast level set-based evolution process and ends with a final refinement stage that integrates a region-based model. The presented implementation employs a set of features based on Grey Level Co-occurrence Matrices, Gabor filters and structure tensors. The high performance of feature extraction and contour evolution stages is achieved with GPU acceleration. The method is validated on synthetic and natural images and confronted with results of the most similar among the accessible algorithms.
Over-indebted Households in Poland: Classification Tree Analysis
Authors: Wałęga Grzegorz , Wałęga Agnieszka 
Published: October 2020

AbstractIncreasing a personal debt burden implies greater financial vulnerability and threats for macroeconomic stability. It also generates a risk of the households over-indebtedness. The assessment of over-indebtedness is conducted with the use of various objective and subjective measures based on the micro-level data. The aim of the study is to investigate over-indebted households in Poland using a unique dataset obtained from the CATI survey. We discuss and compare the usefulness of various over-indebtedness measures across different socio-economic characteristics. Due to the differences in over-indebtedness across single measures, we perform a more complex assessment using a mix of indicators. As an alternative to other commonly criticised over-indebtedness measures, we apply the “below the poverty line” (BPL) measure. In order to obtain the profile of over-indebted households, we use classification and regression tree analysis as an alternative to logit or probit models. We find that DSTI (“debt service to income”) ratio underestimates the extent of over-indebtedness in vulnerable groups of households in comparison with the BPL. We highlight the necessity to use different measures depending on the adopted definition of over-indebtedness. A psychological burden of debts is particularly strong among older and poorly educated respondents. We also find that the age structure of over-indebted households in Poland differs from this structure in countries with a broader access to consumer credits. Our results can be used to enrich the methods of assessing the household over-indebtedness.
Urbanization alters the abundance and composition of predator communities and leads to aphid outbreaks on urban trees
Authors: Korányi Dávid , Szigeti Viktor , Mezőfi László , Kondorosy Előd , Markó Viktor 
Published: October 2020

AbstractUrbanization can affect arthropod abundance in different ways. While species with narrow habitat range and low dispersal ability often respond negatively to urban environments, many habitat generalist species with good dispersal ability reach high densities in city centers. This filtering effect of urban habitats can strongly influence predator-prey-mutualist interactions and may therefore affect the abundance of predatory and phytophagous species both directly and indirectly. Here, we assessed the effect of urbanization on aphids, predatory arthropods, and ants on field maple (Acer campestre) trees in and around the city of Budapest, Hungary. We used the percentage of impervious surfaces within a 500 m radius of each site as an index of the degree of urbanization. We found that the abundance of aphids increased with increasing level of urbanization. However, abundance of predatory arthropods and occurrence of poorly dispersing species within the predator community were negatively related to urbanization, and we identified these two independent factors as significant predictors of aphid abundances. The abundance of ants decreased with urbanization, and contrary to our expectations, did not affect the abundance pattern of aphids. Our results suggest that urbanization, by altering the abundance and composition of predator communities, can disrupt biological control of aphid populations, and thus may contribute to the aphid outbreaks on urban trees.