bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three Worlds of Vocational Education: Specialized and General Craftsmanship in France, Germany, and The Netherlands
Authors: Rözer Jesper , van de Werfhorst Herman G 
Published: April 2020

SummaryOne of the biggest challenges in the design of educational systems concerns how vocational education and training (VET) systems are best organized for the labour markets of tomorrow. Do we need more specialized craftsmen with practical and specific skills that tightly link to specific occupations, or do we need a shift towards broader craftsmen with more general skills? Using microdata from France, Germany, and The Netherlands, we show that there are different ways by which the VET sector establishes school-to-work linkages. Linkages between school to work are on average stronger in systems with a dual VET sector compared to a full school-based model. However, an important reason why linkages are stronger is because of compositional differences, as in dual VET systems more students tend to be enrolled in strongly linking educational programs. Moreover, VET systems are far from homogeneous, and there are large differences in how strong educational programmes link to occupations within and between countries. In general, employment is highest among the stronger linking programs, and this effect is strongest in dual VET systems. These results suggest that there is still room for occupationally oriented schooling.
Magnetic resonance imaging for pathobiological assessment and interventional treatment of the coronary arteries
Authors: Heidt Timo , Reiss Simon , Lottner Thomas , Özen Ali C , Bode Christoph , Bock Michael , von zur Mühlen Constantin 
Published: April 2020

Abstract
X-ray-based fluoroscopy is the standard tool for diagnostics and intervention in coronary artery disease. In recent years, computed tomography has emerged as a non-invasive alternative to coronary angiography offering detection of coronary calcification and imaging of the vessel lumen by the use of iodinated contrast agents. Even though currently available invasive or non-invasive techniques can show the degree of vessel stenosis, they are unable to provide information about biofunctional plaque properties, e.g. plaque inflammation. Furthermore, the use of radiation and the necessity of iodinated contrast agents remain unfavourable prerequisites. Magnetic resonance imaging (MRI) is a radiation-free alternative to X-ray which offers anatomical and functional imaging contrasts fostering the idea of non-invasive biofunctional assessment of the coronary vessel wall. In combination with molecular contrast agents that target-specific epitopes of the vessel wall, MRI might reveal unique plaque properties rendering it, for example, ‘vulnerable and prone to rupture’. Early detection of these lesions may allow for early or prophylactic treatment even before an adverse coronary event occurs. Besides diagnostic imaging, advances in real-time image acquisition and motion compensation now provide grounds for MRI-guided coronary interventions. In this article, we summarize our research on MRI-based molecular imaging in cardiovascular disease and feature our advances towards real-time MRI-based coronary interventions in a porcine model.
Research on a balanced circuit and control strategy
Authors: Zhang LingChao 
Published: April 2020

Abstract
For reducing the inconsistent state of charges (SOC) of lithium-ion battery cells and making the full use of battery packs, effective battery balancing technology should be used. In order to achieve the goal of balancing any single cell in the battery pack expediently and considering the cost and the balance efficiency, a balanced circuit is proposed. By changing the action state of single-pole double-throw relay connected to each of the single cell battery, the balanced single-cell battery is in a state of non-load power supply, at this point, the balanced battery is in `charging’ state compared with other batteries in the battery pack, thus achieving the balance target of the battery pack. On this basis, this paper also proposes a new balancing control strategy; it is different from the traditional control strategy to balance the SOC of the single cell to the SOC average of the battery pack, considering the different SOC change rates of the cells with different capacity in the battery pack. The balanced control strategy proposed in this paper allows the set condition of the single cell to end the equilibrium process in advance so as to reduce the unnecessary balance time and then improve the equilibrium speed. In order to verify the feasibility of the proposed circuit and control strategy, 18 650 batteries with different initial SOC in series are experimentally verified. The experimental results show that the balanced circuit proposed in this paper can well balance the cell of each single cell and make the battery pack reach a balanced state.
Vaginal and Extra-Vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women Who Have Sex With Men
Authors: Fredricks David N , Plantinga Anna , Srinivasan Sujatha , Oot Antoinette , Wiser Andrew , Fiedler Tina L , Proll Sean , Wu Michael C , Marrazzo Jeanne M 
Published: April 2020

Abstract

Background
Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB).

Methods
We used quantitative polymerase chain reaction assays to determine whether presence or concentrations of BVAB in the mouth, anus, vagina, or labia before BV predict risk of incident BV in 72 women who have sex with men.

Results
Baseline vaginal and extra-vaginal colonization with Gardnerella spp, Megasphaera spp, Sneathia spp, BVAB-2, Dialister sp type 2, and other BVAB was more common among subjects with incident BV.

Conclusions
Prior colonization with BVAB is a consistent risk for BV.
Magnetic Solid-Phase Extraction of Drugs and Pesticides from Human Plasma Using COOH-mMWCNTs
Authors: Moon Heesung , Park Jiwon , Hwang Jinwoo , Chung Heesun 
Published: April 2020

Abstract
Carbon nanotubes (CNTs) are useful for extracting chemical compounds due to their properties, such as surface area and the potential for chemical modification. Especially the formation of CNTs with carboxylic acid functional group makes them disperse in water-based samples and have strong interaction forces with cationizable analytes. Based on these features, carboxylic acid functionalized multi-walled CNTs (COOH-MWCNTs) have been used as extraction sorbents. CNT can also be gathered using an external magnet by forming complex with iron oxide (Fe3O4) magnetic nanoparticles (MNPs). In this study, COOH-MWCNTs with MNPs were subjected to magnetic solid-phase extraction (mSPE) in order to extract the targeted substances such as diphenhydramine, doxylamine, tramadol, escitalopram, zolpidem, diphenamid, paclobutrazol, hexaconazole, cyproconazole and mepronil from human plasma samples. The following five factors were optimized: (i) the ratio of COOH-MWCNTs to MNPs as a sorbent from 1:1 to 1:4; (ii) sorbent amount starting from 12.5 to 75%; (iii) sample pH tested pH 2 to pH 10 with 1 N hydrochloride and 1 N sodium hydroxide; (iv) agitating time from 0 to 4 min and (v) elution solvent. Limit of detection of 10 targeted substances in human plasma were in the range of 0.1–0.4 mg/L. The recovery of targeted substances (except diphenamid) in human plasma was 73.06–110.28% for intra-day and 83.00–107.70% for inter-day and the precision (relative standard deviation, %) in human plasma was 0.3–13.3% for intra-day and 2.9–15.6% for inter-day. The method was applied to nine authentic biological samples from overdose patients in the emergency room of Chungnam National University Hospital. The performance of mSPE was compared with the liquid–liquid extraction method using ethyl acetate. The results showed that the newly developed method in this study can be used for screening analysis in forensic and clinical toxicology.
Blood Concentrations of Designer Benzodiazepines: Relation to Impairment and Findings in Forensic Cases
Authors: Heide Gunhild , Høiseth Gudrun , Middelkoop Gerrit , Øiestad Åse Marit Leere 
Published: April 2020

AbstractThe use of designer benzodiazepines appears to be increasing in many countries, but data concerning blood concentrations are scarce, making interpretation of concentrations difficult. The aim of this study was to report blood concentrations of clonazolam, diclazepam, etizolam, flualprazolam, flubromazepam, flubromazolam and phenazepam and to investigate the relationship between blood concentrations and impairment. The concentration data are from blood samples collected from living cases (apprehended drivers and other drug offences) and medico-legal autopsies. The blood samples were analysed for the seven designer benzodiazepines mentioned above by ultra high performance liquid chromatography–tandem mass spectrometry. Positive cases from between 1 June 2016 and 30 September 2019 were included. Blood concentrations and the conclusion from a clinical test of impairment (when available) are reported. The presented seven benzodiazepines were detected in a total of 575 cases, where 554 of these cases concerned apprehended drivers or other criminal offenders. The number of findings and the median (range) concentrations were as follows: clonazolam, n = 22, 0.0041 mg/L (0.0017–0.053 mg/L); diclazepam, n = 334, 0.0096 mg/L (0.0016–0.25 mg/L); etizolam, n = 40, 0.054 mg/L (0.015–0.30 mg/L); flualprazolam, n = 10, 0.0080 mg/L (0.0033–0.056 mg/L); flubromazepam, n = 5, 0.037 mg/L (0.0070–0.70 mg/L); flubromazolam, n = 20, 0.0056 mg/L (0.0004–0.036 mg/L); and phenazepam, n = 138, 0.022 mg/L (0.0018–0.85 mg/L). A designer benzodiazepine was the only drug detected with relevance for impairment in 25 of the 554 living cases. The physician concluded with impairment in 19 of the 25 cases. Most of the concentrations in these cases were relatively similar to or higher than the median reported concentrations. The most frequent other drugs detected were amphetamine, tetrahydrocannabinol, clonazepam and methamphetamine. The presented blood concentrations can be helpful with the interpretation of cases involving one or more of these seven benzodiazepines. The results indicate that concentrations commonly observed in forensic cases are associated with impairment.
Effects of Aerosol Insecticide Application Location on the Patterns of Residual Efficacy Against Tribolium confusum (Coleoptera: Tenebrionidae) Larvae
Authors: Scheff Deanna S , Campbell James F , Arthur Frank H , Zhu Kun Yan 
Published: April 2020

Abstract
Aerosol insecticides are one tool that pest management professionals can utilize as a spatial treatment inside food facilities and storage warehouses. Methods of aerosol application can vary significantly and can affect the spatial pattern of efficacy achieved. We investigated how the location from which an aerosol insecticide is applied inside a mill influenced the spatial dispersal of the insecticide. Treatments were performed using two commercial formulations, pyrethrin + pyriproxyfen (insect growth regulator [IGR]) and pyrethrin + methoprene (IGR), applied at one of three static locations or a fourth application comprising of splitting the application among all three locations. Concrete arenas were placed out at different locations within the mill during applications. At 2, 4, and 6 wk post-aerosol application, Tribolium confusum Jacquelin du Val, confused flour beetle, larvae were added to the concrete arenas and monitored for development and efficacy was evaluated based on percent adult emergence and an efficacy index that ranged from 1 (low) to 21 (high). The spatial pattern of aerosol coverage varied between insecticide formulations and the aerosol application location. Areas of the mill near walls, corners, equipment, and farthest away from the application location had larger zones of low efficacy index values among all four application locations. This study illustrated that the aerosol insecticide formulation, application location, and delivery method all significantly influenced residual efficacies of the insecticides. To increase the overall spatial coverage and IGR efficacy, targeting these areas of a mill floor with the aerosol or additional intervention techniques would increase uniform coverages and overall effectiveness.
Temozolomide and etoposide combination for the treatment of relapsed osteosarcoma
Authors: Akazawa Ryo , Umeda Katsutsugu , Saida Satoshi , Kato Itaru , Hiramatsu Hidefumi , Sakamoto Akio , Arakawa Yoshiki , Sumiyoshi Shinji , Okamoto Takeshi , Moritake Hiroshi , Adachi Souichi , Takita Junko 
Published: April 2020

Abstract
The prognosis of patients with relapsed osteosarcoma is extremely poor and the optimal treatment remains to be identified. Here, we retrospectively analysed the clinical outcomes of nine patients with relapsed osteosarcoma treated with temozolomide/etoposide. Of the two patients who received temozolomide/etoposide as palliative therapy for unresectable tumours, one remained alive with stable disease for &gt;4 years. The remaining seven patients received temozolomide/etoposide as adjuvant therapy following resection of relapsed metastatic disease; of these, one was free from disease for 41 months. Potentially beneficial effects were observed in two of three O6-methylguanine-DNA methyltransferase protein-negative patients, whereas all five O6-methylguanine-DNA methyltransferase-positive patients experienced subsequent relapse. None of the patients experienced severe adverse effects requiring hospitalization. Temozolomide/etoposide is a feasible candidate as salvage therapy for relapsed osteosarcoma. Further studies are needed to verify the utility of O6-methylguanine-DNA methyltransferase protein expression as a biomarker for predicting the response to this treatment.
MS1, a direct target of MS188, regulates the expression of key sporophytic pollen coat protein genes in Arabidopsis
Authors: Lu Jie-Yang , Xiong Shuang-Xi , Yin Wenzhe , Teng Xiao-Dong , Lou Yue , Zhu Jun , Zhang Cheng , Gu Jing-Nan , Wilson Zoe A , Yang Zhong-Nan 
Published: April 2020

Abstract
Sporophytic pollen coat proteins (sPCPs) derived from the anther tapetum are deposited into pollen wall cavities and function in pollen–stigma interactions, pollen hydration, and environmental protection. In Arabidopsis, 13 highly abundant proteins have been identified in pollen coat, including seven major glycine-rich proteins GRP14, 16, 17, 18, 19, 20, and GRP–oleosin; two caleosin-related family proteins (AT1G23240 and AT1G23250); three lipase proteins EXL4, EXL5 and EXL6, and ATA27/BGLU20. Here, we show that GRP14, 17, 18, 19, and EXL4 and EXL6 fused with green fluorescent protein (GFP) are translated in the tapetum and then accumulate in the anther locule following tapetum degeneration. The expression of these sPCPs is dependent on two essential tapetum transcription factors, MALE STERILE188 (MS188) and MALE STERILITY 1 (MS1). The majority of sPCP genes are up-regulated within 30 h after MS1 induction and could be restored by MS1 expression driven by the MS188 promoter in ms188, indicating that MS1 is sufficient to activate their expression; however, additional MS1 downstream factors appear to be required for high-level sPCP expression. Our ChIP, in vivo transactivation assay, and EMSA data indicate that MS188 directly activates MS1. Together, these results reveal a regulatory cascade whereby outer pollen wall formation is regulated by MS188 followed by synthesis of sPCPs controlled by MS1.
InterPred: a webtool to predict chemical autofluorescence and luminescence interference
Authors: Borrel Alexandre , Mansouri Kamel , Nolte Sue , Saddler Trey , Conway Mike , Schmitt Charles , Kleinstreuer Nicole C 
Published: April 2020

Abstract
High-throughput screening (HTS) research programs for drug development or chemical hazard assessment are designed to screen thousands of molecules across hundreds of biological targets or pathways. Most HTS platforms use fluorescence and luminescence technologies, representing more than 70% of the assays in the US Tox21 research consortium. These technologies are subject to interferent signals largely explained by chemicals interacting with light spectrum. This phenomenon results in up to 5–10% of false positive results, depending on the chemical library used. Here, we present the InterPred webserver (version 1.0), a platform to predict such interference chemicals based on the first large-scale chemical screening effort to directly characterize chemical-assay interference, using assays in the Tox21 portfolio specifically designed to measure autofluorescence and luciferase inhibition. InterPred combines 17 quantitative structure activity relationship (QSAR) models built using optimized machine learning techniques and allows users to predict the probability that a new chemical will interfere with different combinations of cellular and technology conditions. InterPred models have been applied to the entire Distributed Structure-Searchable Toxicity (DSSTox) Database (∼800,000 chemicals). The InterPred webserver is available at https://sandbox.ntp.niehs.nih.gov/interferences/.
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data
Authors: Reynisson Birkir , Alvarez Bruno , Paul Sinu , Peters Bjoern , Nielsen Morten 
Published: April 2020

AbstractMajor histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses. MHC molecules come in two main variants: MHC Class I (MHC-I) and MHC Class II (MHC-II). MHC-I predominantly present peptides derived from intracellular proteins, whereas MHC-II predominantly presents peptides from extracellular proteins. In both cases, the binding between MHC and antigenic peptides is the most selective step in the antigen presentation pathway. Therefore, the prediction of peptide binding to MHC is a powerful utility to predict the possible specificity of a T-cell immune response. Commonly MHC binding prediction tools are trained on binding affinity or mass spectrometry-eluted ligands. Recent studies have however demonstrated how the integration of both data types can boost predictive performances. Inspired by this, we here present NetMHCpan-4.1 and NetMHCIIpan-4.0, two web servers created to predict binding between peptides and MHC-I and MHC-II, respectively. Both methods exploit tailored machine learning strategies to integrate different training data types, resulting in state-of-the-art performance and outperforming their competitors. The servers are available at http://www.cbs.dtu.dk/services/NetMHCpan-4.1/ and http://www.cbs.dtu.dk/services/NetMHCIIpan-4.0/.
Expanded Endonasal Approach for Resection of Extradural Infratemporal Fossa Trigeminal Schwannoma: 2-Dimensional Operative Video
Authors: Asmaro Karam , Rock Jack , Craig John 
Published: April 2020

Abstract
The infratemporal fossa (ITF) is bounded superiorly by the skull base, specifically the greater wing of the sphenoid, which contains foramen ovale. It is bordered posteriorly by the temporal bone, including the petrous portion of the carotid canal, anteriorly by the posterior wall of the maxillary sinus, laterally by the mandible, and medially by the pterygoid body and lateral pterygoid plate.
1-3
In this video, we report a case of a rare, exclusively extradural, schwannoma originating from the third division of the trigeminal nerve with a widened foramen ovale at the skull base. The tumor filled the ITF and extended laterally just through the sigmoid notch of the mandible. The patient complained of left cheek and lower jaw numbness and intermittent left jaw spasms. The tumor was deemed appropriate for endoscopic resection. To access the ITF, left-sided endoscopic sinus surgery, a modified endoscopic Denker's approach,
4
and posterior nasal septectomy were first performed. A nasoseptal flap was also harvested in case an intraoperative cerebrospinal fluid (CSF) leak required repair. Dissection was carried out through the posterior wall of the maxillary sinus and pterygopalatine fossa to reach the ITF. Tumor resection was achieved through a 2-surgeon, 4-handed approach in which appropriate traction and countertraction were carefully applied to tease the tumor away from the skull base and dehiscent carotid canal. No CSF leak or carotid injury occurred, and the posterior maxillary sinus wall defect was repaired with the nasoseptal flap. The patient did well postoperatively.
The patient consented to the procedure in a standard fashion.
Mapping types of macromodel to types of macro user
Authors: Wren-Lewis Simon 
Published: April 2020

AbstractThis paper expands on a list of different types of macroeconomic model proposed by Olivier Blanchard. The paper distinguishes between models that range between simple and complex, and between models that range in their focus between data consistency and theoretical consistency. While model users in the private sector and the public sector use a range of different types of model, academics confine themselves largely to models that are internally consistent in terms of their theory. The paper argues that the use of a wider range of models outside academia can no longer be explained by the novelty of DSGE models, and instead reflects some intrinsic advantages of other types of model. Finally the paper considers whether this difference in model use between sectors is beneficial.
Laser-Assisted Indocyanine Green Angiography in the Management of Open Ankle Fractures: A Technical Trick
Authors: Zaharia Pierre P. , Rollick Natalie C. , Otterburn David M. , Wellman David S. 
Published: April 2020

Summary:
Open ankle and pilon fractures in patients with poor soft-tissue quality represent a challenge for the treating orthopaedic surgeon. Occasionally, the typical transverse medial wound is very cephalad and does not allow for the proper visualization of the fracture. It is difficult to decide how to extend these open wounds to get access to the fracture while minimizing disruption of the blood supply to the skin. We describe the use of a new tool, laser-assisted indocyanine green angiography, to assist in incision planning for the definitive treatment of these injuries.
Cell Phone Application to Monitor Pain and Quality of Life in Neurogenic Pain Patients
Authors: Sood Rachita , Stoehr Jenna R. , Janes Lindsay E. , Ko Jason H. , Dumanian Gregory A. , Jordan Sumanas W. 
Published: April 2020

Summary:
Management of postoperative pain is a challenge for healthcare providers in all surgical fields, especially in the context of the current opioid epidemic. We developed a cell phone application to monitor pain, medication use, and relevant quality of life domains (eg, mood, mobility, return to work, and sleep) in patients with neurogenic pain, including those with limb loss. A literature review was conducted to define application length and design parameters. The final application includes 12 questions for patients with limb loss and 8 for patients with neurogenic pain without limb loss. Pilot testing with 21 participants demonstrates acceptable time to complete the application (mean = 158 seconds, SD = 81 seconds) and usability, based on the mHealth App Usability Questionnaire. We aim for our application to serve as an outcome measure for evaluation of an evolving group of peripheral nerve procedures, including targeted muscle reinnervation. In addition, the application could be adapted for clinical use in patients undergoing these procedures for neurogenic pain and thus serve as a tool to monitor and manage pain medication use.