bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect and mechanism of graphene structured palladized zero-valent iron nanocomposite (nZVI-Pd/NG) for water denitration
Authors: Huang Xiangfeng , Zhang Feifan , Peng Kaiming , Liu Jia , Lu Lijun , Li Shiyang 
Published: June 2020

AbstractNitrate reduction by zero-valent iron-based materials has been extensively studied. However, the aggregation of nanoparticles and the preference for unfavored ammonia products limit the application of this technology. To overcome this issue, this study introduced a novel synthesized nanoscale palladized zero-valent iron graphene composite (nZVI-Pd/NG) and explored its nitrate reduction efficiency. A nitrate removal rate of 97.0% was achieved after 120 min of reaction for an initial nitrate concentration of 100 mg N/L. The nitrogen gas selectivity was enhanced from 0.4% to 15.6% at the end point compared to nanoscale zero-valent iron (nZVI) particles under the same conditions. Further analyses revealed that zero-valent metal nanoparticles spread uniformly on the graphene surface, with a thin layer of iron (hydr)oxides dominated by magnetite. The nZVI-Pd/NG exhibited good catalytic activity with the associated activation energy of 17.6 kJ/mol being significantly lower than that with nZVI (42.8 kJ/mol). The acidic condition promoted a higher nZVI utilization rate, with the excess dosage of nZVI-Pd/NG ensuring a high nitrate removal rate for a wide pH range. This study demonstrates an improvement in nitrate reduction efficiency in a nZVI system by combining the exceptional properties of graphene and palladium.
Conceptual Design of a High-flux Multi-GeV Gamma-ray Spectrometer
Authors: Fleck K. , Cavanagh N. , Sarri G. 
Published: June 2020

AbstractWe present here a novel scheme for the high-resolution spectrometry of high-flux gamma-ray beams with energies per photon in the multi-GeV range. The spectrometer relies on the conversion of the gamma-ray photons into electron-positron pairs in a solid foil with high atomic number. The measured electron and positron spectra are then used to reconstruct the spectrum of the gamma-ray beam. The performance of the spectrometer has been numerically tested against the predicted photon spectra expected from non-linear Compton scattering in the proposed LUXE experiment, showing high fidelity in identifying distinctive features such as Compton edges and non-linearities.
New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular carcinoma
Authors: Ferrasi Adriana Camargo , Fernandez Geysson Javier , Grotto Rejane Maria Tommasini , Silva Giovanni Faria , Goncalves Joao , Costa Marina C. , Enguita Francisco J. , Pardini Maria Inês de Moura Campos 
Published: June 2020

AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death in the world, and about 80% of the cases are associated with hepatitis B or C. Genetic and epigenetic alterations are accumulated over decades of chronic injury and may affect the functioning of tumor suppressor genes and protooncogenes. Studies have evidenced the role of Long non-coding RNAs (LncRNA) with oncogenic or tumor suppressor activities, suggesting a great potential in the treatment, diagnosis or indicator of prognosis in cancer. In this context, the aim of this study was to evaluate the global expression profile lncRNA in hepatic tissue samples with different stages of fibrosis associated with chronic hepatitis C, HCC and normal liver, in order to identify new lncRNAs that could contribute to study the progression of hepatic fibrosis to HCC associated with chronic hepatitis C. RNA-Seq was performed on Illumina NextSeq platform to identify lncRNAs expressed differently in 15 patients with chronic hepatitis C, three patients with HCC and three normal liver specimens. When the pathological tissues (fibrosis and carcinoma) were compared to normal hepatic tissue, were identified 2, 6 e 34 differentially expressed lncRNAs in moderate fibrosis, advanced fibrosis and HCC, respectively. The carcinoma group had the highest proportion of differentially expressed lncRNA (34) and of these, 29 were exclusive in this type of tissue. A heat map of the deregulated lncRNA revealed different expression patterns along the progression of fibrosis to HCC. The results showed the deregulation of some lncRNA already classified as tumor suppressors in HCC and other cancers, as well as some unpublished lncRNA whose function is unknown. Some of these lncRNAs are dysregulated since the early stages of liver injury in patients with hepatitis C, others overexpressed only in tumor tissue, indicating themselves as candidates of markers of fibrosis progression or tumor, with potential clinical applications in prognosis as well as a therapeutic target. Although there are already studies on lncRNA in hepatocellular carcinoma, this is the first study conducted in samples exclusively of HCV-related liver and HCV HCC.
Lightweight carbon-red mud hybrid foam toward fire-resistant and efficient shield against electromagnetic interference
Authors: Kumar Rajeev , Sharma Anushi , Pandey Ashutosh , Chaudhary Anisha , Dwivedi Neeraj , Shafeeq M Muhamed , Mondal D. P. , Srivastava A. K. 
Published: June 2020

AbstractLightweight, porous, high-performance electromagnetic interference (EMI) shielding and fire-resistant materials are highly demanded in aerospace and defense applications. Due to the lightweight, open porosity and high surface area, carbon foam has been considered as one of the most promising candidates for EMI shielding applications. In the present investigation, we demonstrate the development of novel carbon-red mud hybrid foams with excellent EMI shielding effectiveness (SE). The carbon-red mud hybrid foams are prepared using phenolic resin as a carbon source and red mud (industrial waste) as filler. We observed that the inclusion of red mud in carbon-red mud hybrid foams significantly enhances their dielectric, magnetic, EMI shielding and thermal properties. The EMI shielding results show that absorption is the main contributor to the total EMI SE. The maximum total EMI shielding effectiveness is achieved to be 51.4 dB in the frequency range of 8.2–12.4 GHz for carbon-red mud hybrid foam having 20 wt. % of red mud. The CF-RM20 also showed excellent fire resistance and high thermal stability at elevated temperatures.
Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle cells
Authors: Uribe Pamela , Johansson Anders , Jugdaohsingh Ravin , Powell Jonathan J. , Magnusson Catarina , Davila Marcela , Westerlund Anna , Ransjö Maria 
Published: June 2020

AbstractSeveral studies have indicated that dietary silicon (Si) is beneficial for bone homeostasis and skeletal health. Furthermore, Si-containing bioactive glass biomaterials have positive effects on bone regeneration when used for repair of bone defects. Si has been demonstrated to stimulate osteoblast differentiation and bone mineralisation in vitro. However, the mechanisms underlying these effects of Si are not well understood. The aim of the present study was to investigate the effects of soluble Si on osteogenic differentiation and connexin 43 (CX43) gap junction communication in cultured pluripotent cells from human dental follicles (hDFC). Neutral Red uptake assay demonstrated that 25 μg/ml of Si significantly stimulated hDFC cell proliferation. Dosages of Si above 100 μg/ml decreased cell proliferation. Alizarin Red staining showed that osteogenic induction medium (OIM) by itself and in combination with Si (25 μg/ml) significantly increased mineralisation in hDFC cultures, although Si alone had no such effect. The expression of osteoblast-related markers in hDFC was analysed with RT-qPCR. OSX, RUNX2, BMP2, ALP, OCN, BSP and CX43 genes were expressed in hDFC cultured for 1, 7, 14 and 21 days. Expression levels of BMP-2 and BSP were significantly upregulated by OIM and Si (25 μg/ml) and were also induced by Si alone. Notably, the expression levels of OCN and CX43 on Day 21 were significantly increased only in the Si group. Flow cytometric measurements revealed that Si (50 μg/ml) significantly increased CX43 protein expression and gap junction communication in hDFC. Next-generation sequencing (NGS) and bioinformatics processing were used for the identification of differentially regulated genes and pathways. The influence of OIM over the cell differentiation profile was more prominent than the influence of Si alone. However, Si in combination with OIM increased the magnitude of expression (up or down) of the differentially regulated genes. The gene for cartilage oligomeric matrix protein (COMP) was the most significantly upregulated. Genes for the regulator of G protein signalling 4 (RGS4), regulator of G protein signalling 2 (RGS2), and matrix metalloproteinases (MMPs) 1, 8, and 10 were also strongly upregulated. Our findings reveal that soluble Si stimulates Cx43 gap junction communication in hDFC and induces gene expression patterns associated with osteogenic differentiation. Taken together, the results support the conclusion that Si is beneficial for bone health.
A Transcriptome Analysis Reveals that Hepatic Glycolysis and Lipid Synthesis Are Negatively Associated with Feed Efficiency in DLY Pigs
Authors: Xu Cineng , Wang Xingwang , Zhuang Zhanwei , Wu Jie , Zhou Shenping , Quan Jianping , Ding Rongrong , Ye Yong , Peng Longlong , Wu Zhenfang , Zheng Enqin , Yang Jie 
Published: June 2020

AbstractFeed efficiency (FE) is an important trait in the porcine industry. Therefore, understanding the molecular mechanisms of FE is vital for the improvement of this trait. In this study, 6 extreme high-FE and 6 low-FE pigs were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs for transcriptomic analysis. RNA-seq analysis was performed to determine differentially expressed genes (DEGs) in the liver tissues of the 12 individuals, and 507 DEGs were identified between high-FE pigs (HE- group) and low-FE pigs (LE- group). A gene ontology (GO) enrichment and pathway enrichment analysis were performed and revealed that glycolytic metabolism and lipid synthesis-related pathways were significantly enriched within DEGs; all of these DEGs were downregulated in the HE- group. Moreover, Weighted gene co-expression analysis (WGCNA) revealed that oxidative phosphorylation, thermogenesis, and energy metabolism-related pathways were negatively related to HE- group, which might result in lower energy consumption in higher efficiency pigs. These results implied that the higher FE in the HE- group may be attributed to a lower glycolytic, energy consumption and lipid synthesizing potential in the liver. Furthermore, our findings suggested that the inhibition of lipid synthesis and glucose metabolic activity in the liver may be strategies for improving the FE of DLY pigs.
Spatial distribution and differences of stroke occurrence in the Rhone department of France (STROKE 69 cohort)
Authors: Freyssenge Julie , Renard Florent , Khoury Carlos El , Derex Laurent , Termoz Anne , Chakir Amine , Douplat Marion , Bravant Estelle , Schott Anne-Marie , Tazarourte Karim 
Published: June 2020

AbstractIn France, 110,000 patients are admitted to hospital per year for stroke. Even though the relationship between stroke and risk factors such as low socio-economic status is well known, research in the spatial distribution (SD) of stroke as a contributing risk factor is less documented. Understanding the geographic differences of the disease may improve stroke prevention. In this study, a statistical spatial analysis was performed using a French cohort (STROKE 69) to describe spatial inequalities in the occurrence of stroke. STROKE 69 was a cohort study of 3,442 patients, conducted in the Rhône department of France, from November 2015 to December 2016. The cohort included all consecutive patients aged 18 years or older, with a likelihood of acute stroke within 24 hours of symptoms onset. Patients were geolocated, and incidence standardized rates ratio were estimated. SD models were identified using global spatial autocorrelation analysis and cluster detection methods. 2,179 patients were selected for analysis with spatial autocorrelation methods, including 1,467 patients with stroke, and 712 with a transient ischemic attack (TIA). Within both cluster detection methods, spatial inequalities were clearly visible, particularly in the northern region of the department and western part of the metropolitan area where rates were higher. Geographic methods for SD analysis were suitable tools to explain the spatial occurrence of stroke and identified potential spatial inequalities. This study was a first step towards understanding SD of stroke. Further research to explain SD using socio-economic data, care provision, risk factors and climate data is needed in the future.
Effect of plant density on yield and Quality of perilla sprouts
Authors: Wu Liuliu , Deng Zhe , Cao Lifan , Meng Li 
Published: June 2020

AbstractGrowth and nutraceutical quality of perilla sprouts is strongly dependent on planting density. This study explored the influence of planting density on growth, photosynthetic parameters, antioxidant capacity, main secondary metabolites, soluble sugar and soluble protein contents of ready-to-eat sprouts. Planting at a density of 1450 plants m−2 significantly increased yield, improved the activities of antioxidant enzymes SOD and CAT, enhanced the generation of reactive oxygen species, increased the content of total chlorophyll and net photosynthetic rate, and decreased the content of MDA in perilla sprouts. The content of flavonoids, volatile oil, soluble sugar and soluble proteins was highest when the density was 1450 plants m−2 compared to other groups. The relative contents of RA and anthocyanin in perilla sprouts reached the maximum value at planting density of 1887 plants m−2.
Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation
Authors: Khilji Saadia , Hamed Munerah , Chen Jihong , Li Qiao 
Published: June 2020

AbstractDeciphering the molecular mechanisms underpinning myoblast differentiation is a critical step in developing the best strategy to promote muscle regeneration in patients suffering from muscle-related diseases. We have previously established that a rexinoid x receptor (RXR)-selective agonist, bexarotene, enhances the differentiation and fusion of myoblasts through a direct regulation of MyoD expression, coupled with an augmentation of myogenin protein. Here, we found that RXR signaling associates with the distribution of myogenin at poised enhancers and a distinct E-box motif. We also found an association of myogenin with rexinoid-responsive gene expression and identified an epigenetic signature related to histone acetyltransferase p300. Moreover, RXR signaling augments residue-specific histone acetylation at enhancers co-occupied by p300 and myogenin. Thus, genomic distribution of transcriptional regulators is an important designate for identifying novel targets as well as developing therapeutics that modulate epigenetic landscape in a selective manner to promote muscle regeneration.
High‐order high‐performance LCLCL DC/DC converter based on harmonic optimisation
Authors: Zhang Xiangjun , Dai Mingcong , Guan Yueshi 
Published: June 2020

This work presents a new type of high‐order LCLCL resonant DC/DC converter. The converter in this study can properly inject the third harmonic for energy transmission through optimal configuration and parameter design of the resonant tank, which can not only achieve a wider voltage regulation range but also provide an easy method for soft start and overcurrent protection. In this study, both switches can realise soft switching, and due to the injection of the third harmonic, the loss of the secondary rectifier diode is reduced. This article describes the working principle of the LCLCL converter and provides the parameter design principle and small‐signal modelling method. In the laboratory, a 400 W prototype with 400 V input and 24 V output is built to verify the correctness of the theoretical analysis.
Analysis of Cassini radio tracking data for the construction of INPOP19a: A new estimate of the Kuiper belt mass
Authors: Di Ruscio A. , Fienga A. , Durante D. , Iess L. , Laskar J. , Gastineau M. 
Published: June 2020

Context. Recent discoveries of new trans-Neptunian objects have greatly increased the attention by the scientific community to this relatively unknown region of the solar system. The current level of precision achieved in the description of planet orbits has transformed modern ephemerides in the most updated tools for studying the gravitational interactions between solar system bodies. In this context, the orbit of Saturn plays a primary role, especially thanks to Cassini tracking data collected during its 13-year mission around the ringed planet. Planetary ephemerides are currently mainly built using radio data, in particular with normal points derived from range and Doppler observables exchanged between ground stations and interplanetary probes.
Aims. We present an analysis of Cassini navigation data aimed at producing new normal points based on the most updated knowledge of the Saturnian system developed throughout the whole mission. We provide additional points from radio science dedicated passes of Grand Finale orbits and Titan flybys. An updated version of the INPOP planetary ephemerides based upon these normal points is presented, along with a new estimate of the mass of trans-Neptunian object rings located in the 2:1 and 3:2 mean motion resonances with Neptune.
Methods. We describe in detail the orbit determination process performed to construct the normal points and their associated uncertainties and how we process those points to produce a new planetary ephemeris.
Results. From the analysis, we obtained 623 new normal points for Saturn with metre-level accuracy. The ephemeris INPOP19a, including this new dataset, provides an estimated mass for the trans-Neptunian object rings of (0.061 ± 0.001)M⊕.
The millimeter-wave spectrum and astronomical search for ethyl methyl sulfide
Authors: Cabezas C. , Bermúdez C. , Tercero B. , Cernicharo J. 
Published: June 2020

Context.Sulfur-containing molecules constitute only 8% of the molecules observed in the interstellar medium (ISM), in spite of the fact that sulfur has been shown to be an abundant element in the ISM. In order to understand the chemical behavior of the ISM and specific cases like the missing sulfur reservoir, a detailed chemical molecular composition in the ISM must be mapped out.Aims.Our goal is to investigate the rotational spectrum of ethyl methyl sulfide, CH3CH2SCH3, which seems to be a potential candidate for observation in the ISM since the simpler analogs, CH3SH and CH3CH2SH, have already been detected. Rotational spectrum of ethyl methyl sulfide has been observed before, but its experimental rotational parameters are not precise enough to allow its detection in the ISM.Methods.The rotational spectrum of ethyl methyl sulfide in the frequency range 72−116.5 GHz was measured using a broadband millimeter-wave spectrometer based on radio astronomy receivers with fast Fourier transform backends. The spectral searches and identification of the vibrational excited states of ethyl methyl sulfide was supported by high-level ab initio calculations on the harmonic and anharmonic force fields.Results.The rotational spectra for the trans and gauche conformers of ethyl methyl sulfide was analyzed, and a total of 172 and 259 rotational transitions were observed for each one, respectively. The observation ofA − Einternal rotation splittings allowed the experimental determination of theV3hindered internal rotation barrier height for both trans and gauche species. In addition, the vibrational excited states, resulting from the lowest frequency vibrational modeν30were identified for both conformers. The new experimental rotational parameters were employed to search for ethyl methyl sulfide in the warm and cold molecular clouds Orion KL, Sgr B2(N), B1-b and TMC-1, using the spectral surveys captured by IRAM 30 m at 3 mm and 2 mm.
Interprofessionelle Versorgung von Patienten mit rheumatoider
Arthritis aus hausärztlicher Sicht: Ergebnisse einer
Querschnittserhebung
Authors: Schneider Elke , Petersen Juliana J. , Schulz-Rothe Sylvia , Gerlach Ferdinand Michael , Rossmanith Tanja , Siebenhofer Andrea , Mergenthal Karola 
Published: June 2020

Zusammenfassung
Ziel der Studie Bei der Behandlung von Patienten mit rheumatoider
Arthritis sind Haus- und Fachärzte, Pflegedienste, Ergo- und
Physiotherapeuten sowie verschiedene andere Berufsgruppen beteiligt. Ziel dieser
Studie ist eine Beschreibung dieser interprofessionellen Kooperationen in der
alltäglichen Versorgungspraxis aus hausärztlicher Sicht.
Methodik Mittels einer Querschnittserhebung wurden von Februar bis
September 2017 die Kooperationen von Hausärzten (n=121 in 68
Praxen) in Hessen und Rheinland-Pfalz mit verschiedenen anderen Versorgern
erfasst. Diese Querschnittserhebung war in die prospektive Kohortenstudie PANORA
(Prävalenz von Anti-CCP-Antikörpern bei Patienten mit neuen
Beschwerden am Bewegungsapparat) integriert. Der verwendete Fragebogen
für Hausärzte enthielt geschlossene Fragen zu Soziodemografie,
Häufigkeit, Gewichtung und Bewertung der bestehenden Kooperationen. Die
erhobenen Daten wurden deskriptiv ausgewertet.
Ergebnisse Bei Betrachtung der von Hausärzten
übernommenen Aufgaben, gaben mehr als 70% der Ärzte an
bei der Betreuung ihrer Patienten mit rheumatoider Arthritis
„oft“ die Koordination der Medikamente, Gespräche
über die Diagnose und Laborkontrollen durchzuführen. Die
häufigste Kooperation mit der größten Wichtigkeit und
einer geringen Zufriedenheit ergab sich mit den Rheumatologen. Als
zweithäufigste Kooperation und hoher Wichtigkeit wurde die Kooperation
mit den Physiotherapeuten bewertet. Die höchste Zufriedenheit wurde mit
der Zusammenarbeit mit Pflegediensten beschrieben.
Schlussfolgerung Die vorliegende Studie zeigt, dass Hausärzte bei
der Versorgung von Patienten mit rheumatoider Arthritis in jedem Stadium der
Versorgung verschiedene Versorgungsaufgaben übernehmen und dabei
unterschiedlich häufig mit anderen Versorgern zusammenarbeiten.
Insbesondere die Zusammenarbeit mit den Rheumatologen und den Physiotherapeuten
ist den Hausärzten wichtig. Jedoch wurde die Kooperation mit
Rheumatologen als unzureichend und verbesserungswürdig beurteilt.