bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed Arterial Switch Operation in a Three Year Old Child with Transposition Of Great Arteries
Authors: Solğun Huseyin Avni , Gojayev Farid 
Published: November 2019

Abstract
Background: The incidence of transposition of the great arteries (TGA) is 0.5-1% of all congenital heart diseases. The aorta and pulmonary arteries exit inversely from the heart ventricles. In addition, 25% of TGA patients have ventricular septal defect (VSD). Some infants may have left ventricular outflow tract obstruction. Arterial switch (Jaten) operation is the accepted procedure for the treatment of TGA. Case report: The patient had congenital severe cyanosis and was diagnosed as TGA, VSD and ASD after a pediatric cardiology examination. The patient went to follow-up for a short time and did not go to follow-up and admitted to our institute with complaints of severe cyanosis and decreased exercise capacity at the age of 34 months. According to echocardiography and angiography findings, arterial switch operation (AS) was planned for treatment despite delayed treatment.Conclusion: In general; it is preferable to perform AS in the first month of life in patients with TGA. There is very rare information in the literature about the preferability of early childhood patients. In the light of this information, we present a case of successful atrial switch operation in a three-year-old patient.
Prevalence of Group B Streptococcus Colonization in Pregnant Women in Jiangsu, East China
Authors: Wang Rui , Qiu Hongmei , Yanmei Ge , Pan Fei , Bian Shuhui 
Published: November 2019

Abstract
Background : Group B streptococcus (GBS) is the leading cause of early-onset neonatal sepsis. This study assessed the prevalence of GBS colonization among pregnant women in Jiangsu, East China. Methods: A total of 16,184 pregnant women at 34 to 37 weeks , gestation aged 16–47 years were recruited from Nanjing Kingmed Diagnostics, including 9022 pregnant women who received GBS screening by PCR detection and 7162 by bacterial culture, antimicrobial susceptibility testing was performed on GBS positive samples. Results: The overall GBS prevalence was 8.7% for pregnant women studied by PCR and 3.5% by culture. The 25-29 age group had the highest rate of GBS colonization in the pregnant women. The prevalence of resistance to erythromycin, clindamycin and levofloxacin was 77.5%, 68.3% and 52.2%, respectively. Conclusions: This study revealed the prevalence characteristics of GBS in pregnant women and the difference of GBS colonization between culture and PCR in Jiangsu province.
Investigation of the Dynamic Regulation Mechanisms of Small Non-Coding RNA in Response to Drought Stress in Qingke Barley
Authors: Zha Sang , Gyalpo Thondup , Zeng Xingquan , Yuan Hongjun , Yu Mingzhai , Xu Qijun , Wang Yulin , Yang Chunbao , Wang Mu , Yang Haizhen , Basang Yuzhen 
Published: November 2019

Abstract
Background Drought is a common abiotic stressor that exerts a great influence on grain security worldwide. The mechanisms underlying the small non-coding RNA regulation of plant drought responses remain unclear.Results In this study, drought-resistant (Xila-16, Xila) and drought-sensitive (DingqingHYG, Diqing) ecotypes were selected. A systematic analysis was performed on the microRNAs and tRNA-derived fragments in small RNA sequencing data. By predicting the target genes of differentially expressed miRNAs and analysing their pathway, this study identified HVUL2H01030.2, HVUL2H06276.2, HVUL2H00175.2 and other important target genes. The analysis also identified base excision repair and other adversity stress-related pathways. tRNA-derived fragments (tRFs), as a novel type of small noncoding RNA, exist widely in organisms, but no study has shown that tRFs play a role in the drought resistance of qingke barley. Based on systematic identification and characteristic analysis of tRFs in small RNA sequencing data, this study found that qingke barley had a tendency to produce more tRFs under drought stress. These tRFs were widely expressed, showed specific tRNA cleavage modes and had conservative intertreatment cleavage and other characteristics.Conclusions Our findings lay the foundation for further investigation of the action mechanism of such novel small noncoding RNAs in the drought resistance of qingke barley.
Reliability and validity of a four-level severity score based triage scale
Authors: Josse Constance , Brodeur Sarah , Callahan Jean-Christophe 
Published: November 2019

Abstract
Background:Triage scales are essential tools for an early and rapid assessment of patients, by classifying them according to their degree of urgency. The objective of this study was to measure the reliability and validity of a four-level severity score based scale.Methods:To evaluate reliability, 250 triage forms were triaged by 6 triage nurses twice, 15 days apart. Intra and inter-rater reproducibility were measured using a weighted Cohen’s Kappa. For the validity study, 485 charts were evaluated. The relationship between triage level and emergency department resource consumption was measured using Spearman’s correlation coefficient. Prediction of severity was measured by the correlation between triage level and hospitalization in any ward, and between triage level and death in the emergency department or hospitalization in an intensive care or high dependency unit. Areas under the ROC curves were measured for these results.Results:For inter-rater reproducibility, the weighted Kappa was measured at 0.51 (95% CI 0.30 – 0.70), and 0.67 (95% CI 0.42 – 0.91) for intra-rater reproducibility. 474 patients were recruited in the validity study, respectively 26 (5%), 50 (11%), 384 (81%) and 14 (3%) for triage levels 1 through 4. Spearman’s correlation coefficient between triage level and emergency department resource consumption was calculated at R = -0.41 (p<0.001). 111 patients were admitted to the hospital with an area under the ROC curve measured at 0.72. 8 patients were admitted to an intensive care or high dependency unit with an area under the ROC curve measured at 0.73.Conclusions:Our study of a four-level severity score based triage scale finds intermediate results in terms of reliability and validity. Further improvements of the scale have to focus on better discriminating between moderately urgent and non-urgent patients.
Community Stakeholder’s Perceptions of the Core Components of a Pediatric Weight Management Intervention
Authors: Fiechtner Lauren , Castro Ines , Simione Meg , O'Connor Giselle , Sharifi Mona , Harris Camille , Gonzalez Vanessa , Perkins Meghan , Torres Shioban , Taveras Elsie , Kuhlthau Karen 
Published: November 2019

Abstract
Background: Multi-sector stakeholder engagement is essential in understanding what is needed for the implementation, dissemination and sustainability of pediatric weight management interventions (PWMI).Methods: We sought to examine the perspectives of stakeholders during the pre-implementation period of a two-arm, PWMI randomized controlled trial (RCT) in federally qualified health centers and YMCAs. We conducted the interviews prior to the implementation of the RCT and reached thematic saturation. Interviews were transcribed and coded using the Consolidated Framework for Implementation Research (CFIR) approach as the intent of the trial was to observe implementation and efficacy outcomes. Our aims were (1) to understand the core components needed for a successful PWMI and (2) to identify determinants and barriers to implementation and future wide-scale dissemination. We conducted the interviews prior to the implementation of the RCT and reached thematic saturation after interviewing 26 stakeholders representing 13 groups. Interviews were transcribed and coded using the framework analysis approach.Results and discussion: We identified themes that stakeholders perceived as core components of a PWMI: a formal curriculum with illustrative examples for patients (i.e. demonstrating how much sugar is in sugary beverages), a patient and family centered program, group visits, and inclusion of high-quality core personnel such as a community health worker, a physician, a behavior health clinician and a dietitian. Determinants of successful implementation and dissemination included partnerships among community and clinical organizations, sustained funding, supportive policies such as insurance reimbursement for community health workers and dietitians, and identifying and addressing needs of dissemination sites, and identifying and addressing patient barriers. These findings helped to identify the core components required for PWMIs and how best to address key determinants affecting implementation and dissemination. Trial registration: ClinicalTrials.gov: NCT03012126; registration date: 12 December 2016, https://clinicaltrials.gov/ct2/show/NCT03012126
iTRAQ-based Comparative Proteomic Analysis of Flag Leaves of Two Wheat (Triticum aestivum L.) Genotypes Differing in Waterlogging Tolerance at Anthesis
Authors: Wei Mingmei , Li LiuLong , Xie Ke , Yang Rui , Wang Xiaoyan , Sha Aihua 
Published: November 2019

Abstract
Background : Waterlogging is one of the major abiotic stresses limiting wheat product. Plants can adapt to waterlogging with changes in morphology, anatomy, and metabolism. Many genes and proteins play critical roles in adaptation to waterlogging.

Results : in this study, the iTRAQ-based proteomic strategy was applied to identify the waterlogging-responsive proteins in wheat. A total of 7,710 proteins were identified in two wheat varieties, XM55 (waterlogging-tolerant) and YM158 (waterlogging-sensitive), at anthesis under waterlogging or not. Sixteen proteins were differentially accumulated between XM55 and YM158 under waterlogging with cultivar specificity. Of these, 11 proteins were up-regulated and 5 proteins were down-regulated. The up-regulated proteins included Fe-S cluster assembly factor, heat shock cognate 70, GTP-binding protein SAR1A-like, and CBS domain-containing protein. The down-regulated proteins contained photosystem II reaction center protein H, carotenoid 9,10 (9',10')-cleavage dioxygenase-like, psbP-like protein 1, and mitochondrial ATPase inhibitor. In addition, 9 proteins were responsive to waterlogging with non-cultivar specificity. These proteins included 3-isopropylmalate dehydratase large subunit, solanesyl-diphosphate synthase 2, DEAD-box ATP-dependent RNA helicase 3, and 3 predicted or uncharacterized proteins. Sixteen out of the 28 selected proteins showed consistent expression patterns between mRNA and protein levels.

Conclusion s: This study revealed that the proteins were differential accumulated between the two contrast waterlogging wheat varieties in response to waterlogging, which provide valuable insights into wheat response to waterlogging stress. The identified differentially accumulated protein might be applied to develop waterlogging tolerant wheat.
A PERSONALIZED APPROACH TO ADJUVANT CHEMOTHERAPY FOR NON-SMALL CELL LUNG CANCER AFTER RADICAL SURGICAL TREATMENT BASED ON MOLECULAR MARKERS OF CHEMOSENSITIVITY
Authors: Efteev L. A. , Rodionov E. O. , Miller S. V. , Tuzikov S. A. , Tsyganov M. M. , Deryusheva I. V. , Litvyakov N. V. , Frolova I. G. 
Published: November 2019

Despite advances in the treatment of non-small cell lung cancer (NSC LC), prognosis of advanced lung cancer is extremely poor. The search for additional treatment options to prevent local recurrence and distant metastases is of great importance. Monoresistance genes, such as ABCC5, BRCA1, RRM1, ERCC1, TOP1, TOP2a, TUBB3, and TYMS play a significant role in tumor sensitivity to chemotherapy for NSC LC. The expression levels of these genes in tumor tissue should be assessed for personalization of adjuvant chemotherapy in patients with NSC LC.Case description. We present a clinical case of a 65-year-old patient diagnosed with non-small cell lung cancer who underwent extended combined surgery followed by 4 courses of personalized adjuvant chemotherapy. The expression levels of monoresistance genes (ABCC5, RRM1, ERCC1, TOP1, TOP2a, TUBB3, BRCA 1 and TYMS) determined by reverse-transcriptase quantitative real-time PCR (RTqPCR) were used as predictive markers of response to adjuvant chemotherapy regimen.Conclusion. Our case report demonstrated the feasibility of performing organ-preserving surgery followed by personalized adjuvant chemotherapy based on the expression levels of monoresistance genes as predictive markers of benefit from adjuvant chemotherapy.
SOLID PSEUDOPAPILLARY TUMOR OF THE PANCREAS IN A MAN: A CASE REPORT
Authors: Shabunin A. V. , Tavobilov M. M. , Paklina O. V. , Setdikova G. R. , Karpov A. A. , Ozerova D. S. 
Published: November 2019

Background. Solid pseudopapillary tumor of the pancreas is a rare neoplasm, accounting for only 1–2 % of all pancreatic neoplasms and having a tendency to affect mainly young women.Material and methods. We report a case of a solid pseudopapillary tumor of the pancreas in a 28-year-old man treated with laparoscopic distal pancreatectomy in Moscow Botkin Hospital.Results. The tumor was discovered incidentally by routine survey ultrasound or computed tomography of the abdomen. The patient underwent distal pancreatectomy with splenectomy. The immunohistochemical study showed a pronounced positive nuclear staining for β-catenin and progesterone and a negative staining for chromogranin A and synaptophysin, thus confirming the presence of solid pseudopapillary tumor of the pancreas.Conclusion. In case of pancreatic tumor, even in male patients, a solid pseudopapillary tumor must be considered in the differential diagnosis. Surgical strategies should be based on the location, size of the tumor and the involvement of adjacent organs, because R0-resection with a solid pseudopapillary tumor leads to a good 5-year survival.
INCIDENCE AND MORTALITY OF CERVICAL CANCER IN THE OMSK REGION
Authors: Goleva O. P. , Tasova Z. B. , Prudnikova O. P. 
Published: November 2019

The purpose of the study was a comparative assessment of the cervical cancer incidence and mortality among females in urban and rural populations of the Omsk region.Material and Methods. The study included females aged over 18 years from urban and rural areas of the Omsk region. According to population-based cancer registry data for the period 2004–16, the crude cancer incidence and mortality rates in urban and rural populations were calculated. The variational and correlation analyzes were used, the differences were assessed using Student t-test.Results. During 2004–16, the cervical cancer incidence among females of the Omsk region showed an increasing tendency, reaching a peak incidence in women aged 35–54. Concerning the cervical cancer mortality rate, it tended to decrease. For rural females, the cervical cancer mortality rate decreased from 10.8 to 9.7 per 100,000 females (p>0.05). For urban females, the mortality rate decreased from 9.2 to 7.5 per 100,000 females (p>0.05). No significant differences in the mortality rates between urban and rural females were found (p>0.05). The tendency towards decreased incidence of advanced cervical cancer (the average decrease being 3.3 % for rural females and 2.8 % for urban females, p>0.05) and increased incidence of early stage cervical cancer (the average rise being 1.8 % and 1.9 %, respectively) was observed.Conclusion. In the Omsk region, the cervical cancer mortality rate for both rural and urban females showed a tendency to decrease. During the study period, the incidence of cervical cancer had increased; however the incidence of advanced cervical cancer had decreased.
CLINICAL OPTIONS FOR METABOLIC SYNDROME IN PATIENTS WITH ENDOMETRIAL CANCER
Authors: Kishkina A. Yu. , Kolomiets L. A. , Yunusova N. V. 
Published: November 2019

Many epidemiological studies have revealed the association between the risk of developing endometrial cancer (EС) and metabolic syndrome (MS) components. A large percentage of patients, especially elderly patients, may have one or more MS components at the time of cancer diagnosis.Objective: to identify the clinical and morphological features of EС, depending on the number of MS components: three-, fourand five-components.Material and Methods. The study included 60 patients with morphologically verified endometrial cancer (T1–3aN0–1M0). All endometrial cancer patients were divided into three groups. Group I included patients with MS, group II – patients with obesity or overweight (ICU ), and group III – patients without MS. Endometrial cancer patients with MS were divided into three subgroups: patients with 3 MS components, with 4 MS components and with 5 MS components.Results. The proportion of endometrial cancer patients with MS was 53.3 %. The median age of the patients was 61.0 ± 2.1 years. The majority of patients had 4 components of MS. Moderately differentiated tumor was observed in 71.8 % of cases, and invasion of less than one-half of the myometrium was observed in 65.3 % of cases. Significant factors of relapse-free survival were: the presence/absence of MS, TG level and the fasting plasma glucose level, thus underlining the effect of MS not only on the development of EС, but also the survival of patients.Conclusions. Our study and many previous studies indicate that the strategies for reducing the prevalence of the components of MS are needed to be developed.
BREAST CANCER TYPING USING RT-PCR ASSAY
Authors: Bozhenko V. K. , Trotsenko I. D. , Kudimnova E. A. , Vardanyan S. G. , Zakharenko M. V. , Solodky V. A. , Makarova M. V. 
Published: November 2019

Introduction. Adjuvant systemic therapy remains one of the main options for treating breast cancer. Results of standard immunohistochemical studies are not always a criterion for selecting systemic therapy. Nowadays, multigene expression analysis is actively used to predict the response to chemotherapy in patients with earlystage breast cancer. We studied a 24-gene multi-gene panel for typing breast cancer.Material and Methods. A prospective analysis of 199 breast cancer patients (T1–3N0–3M0) was carried out. Surgical specimens were studied using the standard immunohistochemistry (IHC) and RT-PCR for detecting expression of 24 genes.Results. According to the IHC results, breast cancer was divided into 5 molecular subtypes: luminal A was detected in 59 (30 %) patients; luminal B (HER2-negative) in 52 (26 %); luminal B (HER2-positive) in 19 (9 %); triple-negative in 28 (14 %); HER2-positive 41 (21 %). RT-PCR showed that ST K15, MYC, MYBL2, BIRCC 5, BCL2, TERT, ESRP1, PGR, HER2, GBR7, MGB1 and MMP11 were the most significant genes in subtype distribution. The total percentage of matches between the two studies was 61.7 %.Conclusion. Studies have shown the need to add additional typing methods for breast cancer to a standard IHC study, which will undoubtedly increase the information content of diagnostic measures and will improve the effectiveness of the treatment.
ADVANCED LARYNGEAL CANCER (LITERATURE REVIEW)
Authors: Radzhabova Z. A-G. , Kotov M. A. , Ebert M. A. , Mitrophanov A. S. , Radzhabova M. A. , Levchenko E. V. 
Published: November 2019

Background. Squamous carcinoma of the larynx is still the most common head and neck cancer in many Western countries. The larynx plays a key role for many essential functions, including breathing, voice production, airway protection, and swallowing. According to the world literature, 23,800 new cases of laryngeal cancer and 106,000 deaths from this disease are registered annually in the world. Laryngeal cancer treatment is aimed at achieving tumor control while optimizing functional outcomes.Objective: to review available data on surgical and non-surgical treatment options for locally advanced laryngeal cancer, as well as the evidence supporting each of these, including oncological outcomes (overall survival, disease-free survival, local control of the disease, functional outcomes and quality of life).Material and Methods. A systematic literature search was conducted in the electronic databases Medline, Cochrane Library, and Elibrary in the interval time between 1987 and 2016.Conclusions. In recent decades, the treatment paradigm for advanced laryngeal cancer has shifted from surgery (total laryngectomy) as the gold standard of treatment to nonsurgical organ-preserving treatment using radiation therapy or chemoradiation therapy. However, concerns have arisen regarding functional outcomes after chemoradiation therapy, as well as a possible reduction in overall survival in laryngeal cancer patients, risk factors, laryngectomy.
The Source of Toxicity of Backwash Water from a Swimming Pool Filter Bed Washings
Authors: LEMPART Anna , KUDLEK Edyta , DUDZIAK Mariusz , ZAWADZKA Aleksandra 
Published: November 2019

Abstract
The necessity of reducing the operating costs of swimming pools leads to attempts to reuse of backwash water from washing swimming pool filter beds. Their use for watering plants, sprinkling tennis courts and play fields, draining to nearby watercourses or even returning to swimming pool installations is taken into consideration. Current researches proved the toxicity of these waste streams. The results of these studies raise doubts about the rightness of the attempts to introduce washings from pool filters directly into the environment. The aim of the presented work is to determine the source of toxicity of filter backwash water. The assessed in the work washings were characterized by high turbidity, high content of both suspended solids and organic compounds. A decrease in value of general impurity indicators after the filtration process of washings has been shown, suggesting that the main source of toxicity may be the suspension, including various anthropogenic organic micropollutants. Although this is just a research hypothesis. For this reason, comparative studies on the occurrence of toxic organic micropollutants in raw filter backwash water, supernatant water and filtrate collected after the filtration process were carried out.
THE IMPORTANCE OF COLOUR AND TEXTURE IN THE DESIGN OF RESIDENTIAL INTERIORS, WITH A PARTICULAR FOCUS ON KITCHENS FOR THE VISUALLY IMPAIRED PEOPLE
Authors: KASZUBA Joanna , SOBCZYŃSKA Karolina 
Published: November 2019

Abstract
People with visual impairments make up a very large part of society. Elderly people, as well as children and young people, are affected by sight impairments that sometimes continue until they lose their sight. These people should be facilitated as to their functioning in the environment through appropriate space design. It is reasonable and advisable to adapt the living quarters in particular to meet their needs. In this study, the authors investigated the preferences for colours and textures in living space, with particular emphasis on the kitchen.
TRADITION AND INNOVATION IN SERBIAN 21ST CENTURY ARCHITECTURE – THE NATURAL, STRUCTURAL MATERIALS’ IMPACT ON THE HUMAN BEING
Authors: MILOŠEVIĆ Predrag , MILOŠEVIĆ Vladimir , MILOŠEVIĆ Grigor 
Published: November 2019

Abstract
The aim of this paper is to illustrate what is happening at present in Serbia through the analysis of traditional Serbian construction, i.e. the technique and the conditions under which it was created. However, as the reality of the subject is quite cruel in today's time, this paper seeks to show the value of the principles on which traditional architecture rests, primarily through the use of natural materials in construction. The reason for this is the inextricable link between man and nature, the very essence of their interconnectedness, as well as the creation of a healthy, aesthetically valuable and quality living space. Based on these analyses, many conceptual solutions will be attached, i.e. the proposal of contemporary interpretation of certain traditional Serbian houses that can meet the needs of modern man and age, where old tradition is implemented in contemporary Serbian architecture.