bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopic Anatomic Reconstruction of the Interosseous Talocalcaneal Ligament Using a Gracilis Autograft for Subtalar Instability: 6- to 12-Year Retrospective Follow-up
Authors: Su Tong , Cheng Xiang-yun , Zhu Yi-chuan , Guo Qin-wei , Hu Yue-lin , Jiao Chen , Jiang Dong 
Published: December 2024

Background: Several surgical techniques have been reported of subtalar instability (STI), but it remains a controversial topic without long-term clinical evidence. This study aimed to report the all-inside arthroscopic anatomic interosseous talocalcaneal ligament (ITCL) reconstruction technique and its long-term outcomes in STI patients with confirmed ITCL rupture. Methods: A retrospective study was conducted on consecutive series of STI patients who underwent all-inside arthroscopic anatomic reconstruction of the ITCL using a gracilis autograft between January 2010 and December 2016. The American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot scale, Karlsson-Peterson score, visual analog scale (VAS) pain score, and Tegner activity scale were assessed preoperatively and postoperatively. Furthermore, Foot and Ankle Ability Measure activities of daily living (FAAM-ADL) and sports (FAAM-Sports) scores, and whether patients returned to daily work, recreational activities, and preinjury sports were recorded at follow-up. Complications including postoperative sprain recurrence, range of motion (ROM) restriction, and incision numbness were evaluated at the final follow-up. Results: A total of 25 patients, with a mean age of 33.3 ± 8.8 years, were included in the follow-up analysis at a mean duration of 110.7 ± 20.4 months. The mean Karlsson-Peterson and AOFAS scores significantly increased from 61.8 ± 9.9 preoperatively to 93.8 ± 7.2 ( P < .001) at the final follow-up and from 68.8 ± 7.4 to 95.1 ± 6.7 ( P < .001), respectively. Additionally, the mean VAS pain score significantly decreased from 4.5 ± 1.1 to 0.6 ± 1.0 ( P < .001). Regarding normal daily activities (FAAM-ADL), 22 patients (88%) obtained good to excellent (≥80) results; for sports-related activities, 18 patients (72%) had good to excellent FAAM-Sports scores and 19 patients (76%) returned to preinjury sports activities. Four patients (16%) reported mild to moderate ROM restrictions. Conclusion: All-inside arthroscopic anatomic reconstruction of the ITCL demonstrated with gracilis autograft was associated with satisfactory long-term outcomes in restoring function and facilitating a return to sports for STI patients with ITCL injury.
Women with Complex Vascular Anomalies: Impact on Contraception, Pregnancy and Reproductive Health
Authors: Coulombe Jerome , Ondrejchak Sandra , Dubois Josee , Powell Julie , McCuaig Catherine , Farrell Catherine , Taillefer Catherine , Rousseau Elisabeth 
Published: December 2024

Background: Literature is scarce regarding contraceptive and reproductive health in women with complex vascular anomalies (VA). Objectives: To assess obstetrical, gynecological and reproductive health in this population. Methods: Female adult patients of childbearing age from the VA clinic of a single tertiary care centre in Canada have been recruited by retrospective chart review, and administered phone interviews. Results: Of the 16 patients recruited (mean age 32.8 years old), 14 used oral contraceptive pills (OCP) and intrauterine devices, with 3 patients experiencing a worsening of their VA under OCP. Fifteen women had children, with 12 experiencing variable worsening of their VA that returned to baseline after delivery or nursing cessation. Three women had severe complications. Degree of complications was variable in each subsequent pregnancy. Conclusion: Contraception and pregnancy management in women should be individualized and coordinated with a VA referral centre.
Comparison of safety and efficacy of femoropopliteal arterial disease using different dose drug-coated balloons: Systematic review and meta-analysis
Authors: Núñez-Castellanos Carlos A , Esquinca-Morales María F , Beristain-Bolaños Meritxell C , De León Avecilla Daniela I , Aguirre-Ocaña Jorge S , Diaz-De-La-Cruz Osiris Y , Anaya-Ayala Javier E , Hinojosa Carlos A 
Published: December 2024

Background Endovascular therapy with balloon percutaneous angioplasty (PTA) in the femoro-popliteal segment is frequently performed, however, long-term favorable outcomes and patency remain challenging, with restenosis rates reaching 60% post-standard balloon angioplasty. Drug-coated balloons (DCBs) have shown promise in improving these outcomes; Paclitaxel, used in DCBs, inhibits hyperplasia and smooth muscle cell proliferation, reducing restenosis; however, the optimal dose of Paclitaxel remains unclear, with high-dose (HD-DCB [>3 mg/mm2]) and low-dose (LD-DCB [<2.0 mg/mm2]) options available. This meta-analysis aims to compare the efficacy and safety of HD-DCB and LD-DCB in treating femoropopliteal arterial disease. Methods We followed PRISMA guidelines and conducted a comprehensive search of PubMed, EMBASE, Cochrane, Scopus, and Mendeley up to May 27, 2024. We included randomized controlled trials and cohort studies comparing HD-DCB and LD-DCB in patients with femoropopliteal arterial disease. Data were extracted on baseline characteristics, outcomes, and study quality. The Newcastle–Ottawa Scale and ROB2 tool were used for bias assessment. Outcomes included overall survival (OS), limb salvage (LS), freedom from clinically driven target lesion revascularization (CD-TLR), and major amputation. Results Six studies comprising 2563 patients were included. HD-DCB showed a significant benefit in limb salvage at 6 months (RR = 0.38, 95% CI = 0.18-0.78, p = .009) but not at 12 months (RR = 3.08, 95% CI = 0.14–67.13, p = .47). No significant difference was observed in overall survival between HD-DCB and LD-DCB at either 6 months (RR = 1.53, 95% CI = 0.25–9.57, p = .65) or 12 months (RR = 1.21, 95% CI = 0.17–8.84, p = .85). HD-DCB was associated with an increased risk of perioperative complications (RR = 1.90, 95% CI = 1.14–3.17, p = .01) and a higher, though not statistically significant, risk of major amputation (RR = 4.73, 95% CI = 0.54–41.52, p = .16). Conclusion HD-DCB may offer advantages in limb salvage over LD-DCB in the short term, but this comes with an increased risk of perioperative complications. These findings underscore the need for careful patient selection when considering HD-DCB for femoropopliteal artery disease.
Coping styles moderate the relationships between general and minority stress and depression among sexual and gender minority populations in Thailand: a cross-sectional study
Authors: Kittiteerasack Priyoth , Steffen Alana , Matthews Alicia K 
Published: December 2024

Background: Sexual and gender minority (SGM) individuals experience elevated rates of depression due to exposure to unique social stressors associated with membership in a stigmatised minority group. Coping style has been shown to buffer or exacerbate responses to stress. To date, little is known about the risk or protective influence of coping styles on the relationships between stressors and depression in SGM populations. Aims: To examine the moderating effects of coping styles on the relationships between stressors and depression in Thai SGMs. Methods: This cross-sectional descriptive survey was conducted between March and August 2018 using in-person and online surveys. Convenience and snowball recruitment strategies were used. Standardised measures were selected according to the Minority Stress Model. Bivariate and multivariate analyses were conducted. Hayes’s PROCESS macro was used to test for significant interactions. Results: Of the 411 participants, 40% of the participants reported symptoms of depression that were associated with multiple stressors. Problem-focused coping was reported by most participants (95.8%), followed by social support (83.1%) and avoidance (49.1%) coping. Problem-focused coping weakened the relationships between stressors and depression, whereas avoidance coping strengthened the relationships between depression and stress, loneliness and discrimination. Social support coping was negatively related to depression, with no statistically significant moderating effects. Conclusions: Problem-focused coping served to mitigate the influence of stressors on depression, whereas avoidance coping strategies exacerbated the impact. Nursing interventions aimed at improving problem-focused coping may reduce the negative consequences of stressors on the mental health of SGMs.
The assessment of reliability and validity of the Thai Versions of the Thirst Distress Scale for patients with Heart Failure and the Simplified Nutritional Appetite Questionnaire in heart failure patients
Authors: Thanapholsart Jenjiratchaya , Khan Ehsan , Janwanishstaporn Satit , Thongma Porntipa , Naowapanich Saowanee , Pramyothin Pornpoj , Chirakarnjanakorn Srisakul , Sethalao Porntera , Tankumpuan Thitipong , Waldréus Nana , Lee Geraldine A. 
Published: December 2024

Background: Heart failure (HF) patients can experience poor appetite and intense thirst. The Thirst Distress Scale for HF (TDS-HF) and the Simplified Nutritional Appetite Questionnaire (SNAQ) are tools used to assess these symptoms. However, these questionnaires are not currently available in Thai. Aims: To translate the TDS-HF and SNAQ into the Thai language and to evaluate the reliability and validity of these translated instruments. Methods: The TDS-HF and the SNAQ were translated from English to Thai using a forward–backward method. Their face and content validity, their internal consistency and test–retest reliability, were assessed with a sample of 20 HF patients recruited from a single supra-tertiary hospital in Thailand. Results: Participants reported that the TDS-HF and the SNAQ had face validity. The content validity was assessed as adequate by the expert panel. The Cronbach’s alphas of the TDS-HF and the SNAQ were 0.91 and 0.71, respectively. The intraclass correlation coefficients of the TDS-HF and the SNAQ were 0.91 and 0.91, respectively. Conclusions: The Thai versions of the TDS-HF and the SNAQ demonstrate adequate validity and reliability. These tools hold significant potential for supporting clinical practice, particularly for nurses involved in HF management by helping to assess thirst and appetite effectively.
Guidelines unmet: Assessing gaps in breast cancer survivorship care
Authors: Pearl Dana , Wilkinson Anna N. 
Published: December 2024

Background: In Canada, after completing their treatment at oncology centers in tertiary care facilities, most breast cancer patients are discharged and receive survivorship care from primary care providers (PCPs). Evidence-based guidelines exist to inform appropriate care for breast cancer survivor follow-up. Objectives: This study analyzed the concordance of breast cancer survivorship follow-up care by PCPs with recommended guidelines at an academic Family Health Team (FHT) in Ottawa. Design: Retrospective chart review of electronic medical records of rostered patients from FHT. Methods: Data was extracted from the charts of 60 breast cancer survivors. Concordance of breast cancer survivorship care by PCPs with evidence-based guidelines was established in three key survivorship domains: surveillance for recurrence or new cancers, management of treatment side effects and preventative health. Results: PCPs provide care concordant with guidelines only 20% of the time, with areas such as preventative care at 86.7% concordance far better than management of side effects at 58.3% and oncological surveillance at 38.3%. Care did not significantly differ by age at diagnosis. Conclusion: These results highlight gaps in the current survivorship care delivery and function as a baseline for comparative analyses for future interventions to optimize survivorship follow-up care.
Efficacy of Essential Oils of Ocimum gratissimum and Mesosphaerum suaveolens Against Culex Quinquefasciatus
Authors: Ojianwuna Chioma C. , Enwemiwe Victor N. , Esiwo Eric , Aghahowa Ehimwenma , Ifeta Sarah , Edhebe Precious , Oborayiruvbe Esegbuyota T. 
Published: December 2024

Background Insecticide resistance is a prevailing global concern mandating the search for alternative control intervention and adopting innovative approaches such as insecticide coated curtains, insecticide-incorporated paints and the possibility of adulticidal trials using the ready-to-use humidifier. Objectives This study critically tested the larvicidal, pupicidal and adulticidal validity of the two plant essential oils, African basil ( Ocimum gratissimum) and pignut leave ( Mesosphaerum suaveolens) on Cx. quinquefasciatus Methodology Twenty, third instar larvae and pupae of Cx. quinquefasciatus were introduced into vials containing 1 ml and 0.5 ml of the essential oil in100 ml, 250 ml and 500 ml of water to form 0.01%, 0.001%, 0.002% 0.004% and 0.005% concentrations respectively. The exposure was done in triplicates. Mortality readings were taken at intervals of 10, 15, 20, 30, 40, 50, and 60 min adhering strictly to the WHO standard protocols. The highest concentrations, 0.01% (1 ml:100 ml) and 0.005% (0.5 ml:100 ml), were tried on adult mosquitoes in a 200 cm squared cage using ready-to-use humidifier. Results Mean mortality was highest in larvae exposed to O. gratissimum. Pupicidal activities of O. gratissimum oil was higher than M. suaveolens. Adult mosquitoes exposed to 0.005% of both plant oils caused highest mortality. The differences between the mean mortalities were significant (p < .05). Lethal Concentration (LC50 and LC95) of O. gratissimum and M. suaveolens exposed to larvae were 0.011 and 0.021%, and 0.024 and 0.042% respectively. Similarly, for pupicidal exposure, LC50 and LC95 were 0.019 and 0.041%, and 0.041 and 0.072% respectively. O. gratissimum oil was more efficacious especially for larval control. Conclusion Adulticidal efficacy of the essential oils can be enhanced through anticipated efforts towards emulsifying and synergizing them with other plant oils.
Stigma and associated sex disparities among patients with tuberculosis in Uganda: a cross-sectional study
Authors: Sekandi Juliet N. , Quach Trang , Olum Ronald , Nakkonde Damalie , Farist Leila , Obiekwe Rochelle , Zalwango Sarah , Buregyeya Esther 
Published: December 2024

Background: Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. The stigma associated with TB, encompassing self, anticipated, and public stigma, has significant negative effects on treatment adherence. In Uganda, limited data exist on the prevalence of stigma and its relationship with sex among patients with TB. Objectives: We aimed to evaluate the prevalence of three types of stigma and their relationship with the sex of patients undergoing TB treatment. Design: Cross-sectional study. Methods: This cross-sectional study was conducted among patients living with TB attending selected TB clinics in Kampala, Uganda, between July 2020 and March 2021. We collected data on sociodemographics and used 13 items to capture the self, anticipated, and public stigma from which we composed the dependent variables. We employed multivariable logistic regression analysis to evaluate the association between sex and the three stigma types. Additionally, we considered potential confounders such as age, HIV, and employment status. Statistical significance was defined as p < 0.05. Results: In this study, we enrolled 144 participants with a mean age of 35.8 years (standard deviation = 12). Half of the participants were female, 44.4% had a secondary education, 37.5% were unemployed, and 32.6% were living with both HIV and TB. The prevalence of self-stigma was 71.1%, anticipated stigma was 75.7%, and public stigma was 41.7%. Significant factors associated with self-stigma were female sex (adjusted odds ratio (AOR): 2.35, 95% confidence interval (CI): 1.02–5.74) and unemployment (AOR: 2.95, 95% CI: 1.16–8.58). Living with HIV was significantly associated with anticipated stigma (AOR: 3.58, 95% CI: 1.38–11.23). However, none of the evaluated variables showed a significant association with public stigma. Conclusion: Our study showed a relatively high prevalence of self, anticipated, and public stigma among TB patients. Notably, females and unemployed individuals were at a higher risk of self-stigma, while those with HIV/AIDS and TB were more likely to report anticipated stigma. To combat stigma effectively, interventions should be tailored to cater to sex-specific needs and persons living with HIV. Future research should delve further into determinants of TB-related stigma in high-burden settings.
Radiomics and radiogenomics: extracting more information from medical images for the diagnosis and prognostic prediction of ovarian cancer
Authors: Zeng Song , Wang Xin-Lu , Yang Hua 
Published: December 2024

AbstractOvarian cancer (OC) remains one of the most lethal gynecological malignancies globally. Despite the implementation of various medical imaging approaches for OC screening, achieving accurate differential diagnosis of ovarian tumors continues to pose significant challenges due to variability in image performance, resulting in a lack of objectivity that relies heavily on the expertise of medical professionals. This challenge can be addressed through the emergence and advancement of radiomics, which enables high-throughput extraction of valuable information from conventional medical images. Furthermore, radiomics can integrate with genomics, a novel approach termed radiogenomics, which allows for a more comprehensive, precise, and personalized assessment of tumor biological features. In this review, we present an extensive overview of the application of radiomics and radiogenomics in diagnosing and predicting ovarian tumors. The findings indicate that artificial intelligence methods based on imaging can accurately differentiate between benign and malignant ovarian tumors, as well as classify their subtypes. Moreover, these methods are effective in forecasting survival rates, treatment outcomes, metastasis risk, and recurrence for patients with OC. It is anticipated that these advancements will function as decision-support tools for managing OC while contributing to the advancement of precision medicine.
Gonadotropin Therapy for Mini-Puberty Induction in Male Infants With Hypogonadotropic Hypogonadism
Authors: Rhys-Evans Sophie , d’Aniello Francesco , Alexander Emma C , Dinah Ibrahim F , Heger Sabine , Nordenstrom Anna , Rohayem Julia , Howard Sasha R 
Published: December 2024

Abstract

Context
Congenital hypogonadotropic hypogonadism (CHH) is defined as an isolated deficiency of gonadotropin hormones. Mini-puberty, a transient postnatal activation of the hypothalamic-pituitary-gonadal axis in healthy infants, provides a window of opportunity to diagnose and treat CHH. Currently, in male infants with CHH, testosterone is used to increase phallus size. However, gonadotropin replacement could additionally promote testicular descent and development, particularly relating to Sertoli cells. We conducted a systematic review of the effectiveness of gonadotropin therapy in stimulating mini-puberty related outcomes in male infants with CHH.

Evidence Acquisition
In line with PRISMA guidelines, a systematic review of 11 databases was carried out (August 2023). Evidence quality was assessed using the Cochrane Risk of Bias for Non-Randomised Studies of Interventions tool. Protocol registered on PROSPERO (CRD42023453080).

Evidence Synthesis
After a double-consensus screen of 767 abstracts and 66 full texts, 11 studies were included from 7 countries. A total of 71 male infants were enrolled, 12 with Kallmann syndrome. Median age at treatment initiation was 4.2 months (range, 0.25-57 months) and follow-up ranged from 3 to 10 years. Gonadotropin therapy was administered using continuous subcutaneous infusion (n = 35) or subcutaneous injection (n = 36). Due to treatment variability, modalities were combined for data synthesis. Gonadotropins induced a statistically significant increase in penile length and inhibin B concentration (P = .0007) and led to partial or full testicular descent in 73% (n = 62) of patients.

Conclusion
This systematic review provides unique evidence supporting the efficacy of gonadotropins for induction of mini-puberty. However, the reliability and generalizability are limited due to disparate data and treatment modality variation.
ÇAĞDAŞ TÜRK SERAMİK SANATINDA İNSAN YÜZÜ VE İFADE OLANAKLARI
Authors: Ulker Huri , Poyraz Mine 
Published: December 2024

Anadolu, pek çok medeniyete ve uygarlığa ev sahipliği yapmış, dünya coğrafyasının zengin kültürel mirasa sahip topraklarında bulunmaktadır. Anadolu topraklarında seramik üretimi, Neolitik Dönem’den günümüze kap kacak, idoller vb. pek çok örneklerle varlığını sürdürmüştür. Selçuklu ve Osmanlı Dönemi sonrası İznik, Kütahya ve Çanakkale gibi merkezlerde geleneksel olarak devam eden seramik üretimi Cumhuriyetin ilanı ve sonrasında çağdaş seramik sanatı olarak gelişimine devam etmiştir.
“Yüz”ümüz, kimliğimiz olarak düşündüğümüzde, iç dünyamızın dışavurumudur. Türkçe Sözlük’e göre “Başımızda yer alan alın, göz, burun, ağız, yanak ve çenenin üstünde bulunduğu yer; çehre, beniz, sima, surat, suret.” şeklinde tanımlanmaktadır. İnsanın geçmişten günümüze kadar en önemli konusu olan yüz, sanatın içinde pek çok esere konu olmuş, insan figürü ve yüzü tarihsel süreçte üretilen seramiklerde, çeşitli form ve yüzeylerde sıklıkla kullanılmıştır.
Cumhuriyet’in ilanı, çağdaş Türk seramik sanatının oluşup gelişmesinde önemli bir rol oynamıştır. Bu dönem ve sonrasında, eserlerinde insan yüzü ve mimiklerini konu olarak ele almış seramik sanatçılarımız araştırılmıştır. Araştırma sonucunda, 1970’li yıllarda Füreya Koral, Nasip İyem, Sadi Diren, Ayfer Karamani, Erdinç Bakla, İlgi Adalan; sonrasındaki dönemde Tüzüm Kızılcan ve Güngör Güner; 1980’den günümüze kadarki zaman diliminde ise Sibel Sevim, Armağan Ulusoy, Deniz Onur Erman, Arzu Türk, Tevfik Karagözoğlu ve Orçun İlter’in, eserlerinde insan yüzü ve ifadelerini konu olarak ele aldıkları görülmüştür.
Yapılan araştırmada, konu olarak insan yüz ve mimiklerini kullanan çağdaş Türk seramik sanatçılarının eserleri üzerinden, seramik sanatında yüz ve mimiklerin kullanımı ve ifade olanakları incelenmiştir. Bu sanatçıların eserlerindeki duygu durum ve temalarını ifade etme şekillerinde, insan yüzü ve mimiklerinin kullanım şekilleri üzerinde durulmuş, bu alanda çalışmak isteyen araştırmacılara kaynak oluşturmak hedeflenmiştir.