bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is preoperative glenoid bone mineral density associated with aseptic glenoid implant loosening in anatomic total shoulder arthroplasty?
Authors: Mariaux Sandrine , Obrist Raphaël , Farron Alain , Becce Fabio , Terrier Alexandre 
Published: December 2020

Abstract
Background: Aseptic loosening of glenoid implants is the primary revision cause in anatomic total shoulder arthroplasty (aTSA). While supported by biomechanical studies, the impact of glenoid bone quality, more specifically bone mineral density (BMD), on aseptic glenoid loosening remains unclear. We hypothesized that lower preoperative glenoid BMD was associated with aseptic glenoid implant loosening in aTSA.Methods: We retrospectively included 93 patients (69 females and 24 males; mean age, 69.2 years) who underwent preoperative non-arthrographic shoulder computed tomography (CT) scans and aTSA between 2002 and 2014. Preoperative glenoid BMD (CT numbers in Hounsfield unit) was measured in 3D using a reliable semi-automated quantitative method, in the following six contiguous volumes of interest (VOI): cortical, subchondral cortical plate (SC), subchondral trabecular, and three successive adjacent layers of trabecular bone. Univariate Cox regression was used to estimate the impact of preoperative glenoid BMD on aseptic glenoid implant loosening. We further compared 26 aseptic glenoid loosening patients with 56 matched control patients.Results: Glenoid implant survival rates were 89% (95% confidence interval CI, 81%-96%) and 57% (41%-74%) at 5 and 10 years, respectively. Hazard ratios for the different glenoid VOIs ranged between 0.998 and 1.004 (95% CI [0.996, 1.007], p≥0.121). Only the SC VOI showed significantly lower CTn in the loosening group (622±104 HU) compared with the control group (658±88 HU) (p=0.048), though with a medium effect size (d=0.42). There were no significant differences in preoperative glenoid BMD in any other VOI between patients from the loosening and control groups.Conclusions: Although the preoperative glenoid BMD was statistically significantly lower in the SC region of patients with aseptic glenoid implant loosening compared with controls, this single-VOI difference was only moderate. We are thus unable to prove that lower preoperative glenoid BMD is clearly associated with aseptic glenoid implant loosening in aTSA. However, due to its proven biomechanical role in glenoid implant survival, we recommend extending this study to larger CT datasets to further assess and better understand the impact of preoperative glenoid BMD on glenoid implant loosening/survival and aTSA outcome.Trial registration: Retrospectively registered
Data assimilation in hydrodynamic models for system-wide soft sensing and sensor validation for urban drainage tunnels
Authors: Palmitessa Rocco , Mikkelsen Peter Steen , Law Adrian W. K. , Borup Morten 
Published: December 2020

Abstract
Tunnels are increasingly used worldwide to expand the capacity of urban drainage systems, but they are difficult to monitor with sensors alone. This study enables soft sensing of urban drainage tunnels by assimilating water level observations into an ensemble of hydrodynamic models. Ensemble-based data assimilation is suitable for non-linear models and provides useful uncertainty estimates. To limit the computational cost, our proposed scheme restricts the assimilation and ensemble implementation to the tunnel and represents the surrounding drainage system deterministically. We applied the scheme to a combined sewer overflow tunnel in Copenhagen, Denmark, with two sensors 3.4 km apart. The downstream observations were assimilated, while those upstream were used for validation. The scheme was tuned using a high-intensity event and validated with a low-intensity one. In a third event, the scheme was able to provide soft sensing as well as identify errors in the upstream sensor with high confidence.
Household levels of deprivation to WaSH and residential conditions in slum settlements of Lagos, Nigeria
Authors: Akoteyon Isaiah Sewanu , Aliu Ibrahim Rotimi , Soladoye Olayemi 
Published: December 2020

Abstract
Household levels of deprivation to water, sanitation, and hygiene (WaSH) and residential conditions in slum settlements of Lagos, Nigeria were assessed and mapped using slum deprivation index (SDI). A structured questionnaire was administered to 1,398 households in 16 settlements using a random sampling method. Descriptive statistics and SDI were employed to analyze the data while ArcMap was used to map the patterns of SDI. The results show that households live in poor dwelling conditions with limited access to WaSH facilities. The SDI indicates that 18.7% of the slums are highly deprived. Based on WaSH and dwelling and physical environment (DPE) components, 18.75 and 31.25% of the slums are highly deprived. Water, sanitation, and hygiene indicators show that 37.5, 12.5, and 56.25% of the slums are highly deprived respectively. About 50, 37.5, 43.75, and 31.25% of the slum are highly deprived based on dwelling, waste disposal, waste pile, and stagnant water respectively. The study concluded that six settlements live in deplorable WaSH and DPE conditions. The study recommends urgent intervention for planning and resources allocation, and sustained urban renewal programs at Oko-Baba, Ilaje, Oko-Agbon, Abule-Nla, and Badia for improved WaSH and living conditions for sustainable service delivery and healthy slum settlements.
Using a fractional order grey seasonal model to predict the dissolved oxygen and pH in the Huaihe River
Authors: Zhang Kai , Wu Lifeng 
Published: December 2020

Abstract
To accurately forecast the seasonal fluctuations of dissolved oxygen (DO) and pH in Huaihe River, a grey seasonal model with fractional order accumulation is proposed, optimized by particle swarm optimization (PSO-FGSM(1,1)). We use this new model to carry out an empirical analysis based on the DO and pH data from 2014 to 2018 from Huaibin, Bengbu, Chuzhou monitoring points. The comparison results show that the PSO-FGSM(1,1) model accuracy is significantly higher than the Holt-Winters model with grey wolf optimization (GWO-Holt-Winters). The prediction results indicated that the pollution of the Huaihe River has regional characteristics. The Huaibin and Chuzhou sections of the Huaihe River are slightly polluted, and the Bengbu section is seriously polluted.
Learning from Metabolic Networks: Current Trends and Future Directions for Precision Medicine
Authors: Granata Ilaria , Manzo Mario , Kusumastuti Ari , Guarracino Mario R. 
Published: December 2020

Background:
Systems biology and network modeling represent, nowadays, the
hallmark approaches for the development of predictive and targeted-treatment based precision
medicine. The study of health and disease as properties of the human body system allows
the understanding of the genotype-phenotype relationship through the definition of
molecular interactions and dependencies. In this scenario, metabolism plays a central role as
its interactions are well characterized and it is considered an important indicator of the genotype-
phenotype associations. In metabolic systems biology, the genome-scale metabolic
models are the primary scaffolds to integrate multi-omics data as well as cell-, tissue-, condition-
specific information. Modeling the metabolism has both investigative and predictive
values. Several methods have been proposed to model systems, which involve steady-state
or kinetic approaches, and to extract knowledge through machine and deep learning.

Methods:
This review collects, analyzes, and compares the suitable data and computational
approaches for the exploration of metabolic networks as tools for the development
of precision medicine. To this extent, we organized it into three main sections: "Data and
Databases", "Methods and Tools", and "Metabolic Networks for medicine". In the first
one, we have collected the most used data and relative databases to build and annotate
metabolic models. In the second section, we have reported the state-of-the-art methods
and relative tools to reconstruct, simulate, and interpret metabolic systems. Finally, we
have reported the most recent and innovative studies that exploited metabolic networks to
study several pathological conditions, not only those directly related to metabolism.

Conclusion:
We think that this review can be a guide to researchers of different disciplines,
from computer science to biology and medicine, in exploring the power, challenges
and future promises of the metabolism as predictor and target of the so-called P4 medicine
(predictive, preventive, personalized and participatory).
Stability of Ketoprofen Methylester in Plasma of Different Species
Authors: Hu Steven X. , Ernst Kelsey , Benner Charles P. , Feenstra Kenneth L. 
Published: December 2020

Background:Pharmacokinetic and pharmacodynamic assessment of ester-containing drugs can be impacted by hydrolysis of the drugs in plasma samples post blood collection. The impact is different in the plasma of different species.Objective:This study evaluated the stability of a prodrug, ketoprofen methylester (KME), in commercially purchased and freshly collected plasma of mouse, rat, dog, cat, pig, sheep, cattle and horse.Methods:KME hydrolysis was determined following its incubation in commercially purchased and freshly collected plasma of those species. Different esterase inhibitors were evaluated for prevention of the hydrolysis in rat, dog and pig plasma.Results:KME was rapidly hydrolyzed in both commercially purchased and freshly collected plasma of mouse, rat, and horse. The hydrolysis was initially quick and then limited in cat plasma. KME hydrolysis was minimum in commercially purchased plasma of dog, pig, sheep and cattle but substantial in freshly collected plasma of those species. Different esterase inhibitors showed different effects on the stability of KME in rat, dog and pig plasma.Conclusion:These results indicate that plasma of different species has different hydrolytic activities to estercontaining drugs. The activities in commercially purchased and freshly collected plasma may be different and species-dependent. Esterase inhibitors have different effects on preventing hydrolysis of the ester-containing drugs in the plasma of different species.
Analytical Protocol for Monitoring Workplace Surface Contamination with Capecitabine
Authors: Stoeva Stanila , Marinov Petko 
Published: December 2020

Background:
The risk of toxicity for the healthy individuals who are chronically exposed
to cytostatic drugs was established in 1970s. Since then, many institutions have recommended
monitoring occupational exposure to antineoplastic agents. Nevertheless, there is still a lack of
analytical procedures for this inspection. The prodrug Capecitabine is an example of a cytostatic
drug that has never been analyzed for the purpose of occupational exposure inspection. Thus, the
objective of the present study was to develop a suitable protocol for its evaluation on workplace
surfaces.

Methods:
The determination of the surface residue of Capecitabine has been carried out in a laboratory
setting through аn HPLC-UV method, preceded by an appropriate sample preparation procedure,.
It was used for the pre-and post-cleaning analysis of wipe samples from several working
sites, which are assessed as the most likely ones for the occurrence of dermal contact with the prodrug.

Results:
The applied HPLC-UV method was assessed as accurate and precise, with an established
limit of quantification of 0.05 μg/mL. The analytical procedure provided a recovery of Capecitabine
of more than 90%. During the analytical protocol approbation, one surface sample containing
Capecitabine was detected. To determine the efficiency of routine hygiene measures, wipe samples
from all tested surfaces were analyzed after a cleaning procedure. However, the cytostatic presence
was not determined on any area, including the area that gave a positive result.

Conclusion:
The analytical protocol developed here successfully permits, for the first time, to
study the surface contamination with the cytotoxic agent, Capecitabine. Due to this, it can be concluded
that the proposed method could be useful for institutions where a potential risk of contamination
to the prodrug exists.
Factors Associated with Blood Donation Practice among College Students in Southwest Ethiopia
Authors: Yosef Tewodros , Wondimu Wondimagegn , Zewudie Ameha , Tesfaw Aragaw 
Published: December 2020

Background:
Blood transfusion is a crucial element of health care. It contributes to saving millions of lives both in routine and emergencies each year. However, millions of patients do not have timely access to this vital resource in Low-income Countries (LICs), including Ethiopia. Eventhough some shreds of evidence are available at the national level, specific studies regarding blood donation practice among college students are limited. Therefore, this study aimed to assess the magnitude and factors associated with blood donation practice among college students in southwest Ethiopia.

Methods:
A cross-sectional study was conducted among 429 Mizan-Aman health science college students from June 01 to 15, 2019. The data were collected using a self-administered questionnaire. The data were entered and cleaned using EPI-Data version 4.2.0.0, then analyzed using SPSS version 20 software.

Results:
Of the 394 participants, the practice of blood donation was 35.5% (140), 95% CI (30.8%-40.2%). Of the 140 participants, 72 (51.4%) and 120 (85.7%) of the respondents were one-time donors and voluntary blood donors, respectively. The factors associated with the practice blood donation were aged ≥ 23 years, former urban residence, having a mother with primary school completed, having good knowledge, and a positive attitude toward blood donation.

Conclusion:
The practice of blood donation was not adequate among study populations. Therefore, the consideration of encouragement campaigns and educational sessions within the campus will play paramount importance in the increment of blood donation practice.
Exploring the Cost of eLearning in Health Professions Education: Scoping Review
Authors: Meinert Edward , Eerens Jessie , Banks Christina , Maloney Stephen , Rivers George , Ilic Dragan , Walsh Kieran , Majeed Azeem , Car Josip 
Published: December 2020

Background
Existing research on the costs associated with the design and deployment of eLearning in health professions education is limited. The relative costs of these learning platforms to those of face-to-face learning are also not well understood. The lack of predefined costing models used for eLearning cost data capture has made it difficult to complete cost evaluation.

Objective
The key aim of this scoping review was to explore the state of evidence concerning cost capture within eLearning in health professions education. The review explores the available data to define cost calculations related to eLearning.

Methods
The scoping review was performed using a search strategy with Medical Subject Heading terms and related keywords centered on eLearning and cost calculation with a population scope of health professionals in all countries. The search was limited to articles published in English. No restriction was placed on literature publication date.

Results
In total, 7344 articles were returned from the original search of the literature. Of these, 232 were relevant to associated keywords or abstract references following screening. Full-text review resulted in 168 studies being excluded. Of these, 61 studies were excluded because they were unrelated to eLearning and focused on general education. In addition, 103 studies were excluded because of lack of detailed information regarding costs; these studies referred to cost in ways either indicating cost favorability or unfavorability, but without data to support findings. Finally, 4 studies were excluded because of limited cost data that were insufficient for analysis. In total, 42 studies provided data and analysis of the impact of cost and value in health professions education. The most common data source was total cost of training (n=29). Other sources included cost per learner, referring to the cost for individual students (n=13). The population most frequently cited was medical students (n=15), although 12 articles focused on multiple populations. A further 22 studies provide details of costing approaches for the production and delivery of eLearning. These studies offer insight into the ways eLearning has been budgeted and project-managed through implementation.

Conclusions
Although cost is a recognized factor in studies detailing eLearning design and implementation, the way cost is captured is inconsistent. Despite a perception that eLearning is more cost-effective than face-to-face instruction, there is not yet sufficient evidence to assert this conclusively. A rigorous, repeatable data capture method is needed, in addition to a means to leverage existing economic evaluation methods that can then test eLearning cost-effectiveness and how to implement eLearning with cost benefits and advantages over traditional instruction.
Entre los intersticios de la democracia: Las revistas estudiantiles, la universidad uruguaya en transición y las pujas políticas por los significados de la democracia
Authors: González Vaillant Gabriela 
Published: December 2020

El presente trabajo analiza el proceso de reorganización del movimiento estudiantil universitario uruguayo en los primeros años de la década de los ochenta y especialmente en periodo comprendido entre 1980 y 1983. El trabajo busca rastrear la génesis de la (re)constitución de este actor social a través de una mirada atenta a las revistas estudiantiles, proponiendo una mirada alternativa a la transición democática más allá de lo político partidario. El trabajo concluye que las revistas estudiantiles constituyeron canales alternativos de expresión, pero también espacios privilegiados para forjar y catalizar una identidad y sensibilidad generacional y estudiantil determinada durante un período en que no se encontraban disponibles canales tradicionales de participación y militancia.
*Este artículo fue publicado originalmente en 2018, en el volumen 22(2) de la Revista de Historia Social y de las Mentalidades, editada por elDepartamento de Historia de la Facultad de Humanidades de la Universidad de Santiago de Chile (ISSN: 0717-5248 ISSN en línea: 0719-4749). Enlace al artículo original: http://www.revistas.usach.cl/ojs/index.php/historiasocial/article/view/3643/26002939
Reseñas bibliográficas
Authors: Brando Oscar , Keldjian Etchessarry Julieta 
Published: December 2020

Reseñas de los libros:
- Cultura y cinefilia. Historia del público de la Cinemateca Uruguaya, de Germán Silveira. Escribe Oscar Brando.
- La conquista del espacio. Cine silente uruguayo (1915-1932), de Georgina Torello. Escribe Julieta Keldjian Etchessarry.
Justification of the Gravitational Seed Cleaning System Parameters
Authors: Khamuev V. G. 
Published: December 2020

The author researched the gravitational method of separating a grain heap, in which cleaning from large and small impurities was carried out without energy consumption, with the gravity material fl ow in vertical cleaning columns along fi xed zigzag separating combs.(Research purpose) To study the gravity column operation for cleaning selection seeds and substantiate its design parameters.(Materials and methods) A prototype gravity column was developed. The author experimentally determined: the combs teeth diameter; column throughput; the possibility of a more complete separation of the seed fraction from the basic material; completeness of large impurities separation. He compared the work of the gravity column and the fl at rocking sieve. He assessed the combs jamming by the cleaned culture seeds.(Results and discussion) The author noted that on wheat cleaning at a productivity of 45.6 kilogram per hour, the yield of the "waste" fraction was 0.5 percent, a loss of 0.07 percent, and at a productivity of 227.8 kilogram per hour – 0.98 and 0.35 percent, which corresponded to the initial requirements for the main technological operations for post-harvest processing of selection seeds.(Conclusions) It was found that a gravity column for separating selection wheat seeds small impurities separated particles with high effi ciency if they diff ered from each other in thickness of at least 0.3 millimeter with a gap between the comb bars of 2.0 millimeter and a bar cross-section diameter of 0.9 millimeter. It was determined that high productivity – up to 150 kilogram per hour – was possible with a column cross-section with sides of 60 and 70 millimeter. The author revealed practically the same quality of material separation when separating small impurities using both a sieve and a gravity column.
Application of Vegetation Indexes to Assess the Condition of Crops
Authors: Kurbanov R. K. , Zakharova N. I. 
Published: December 2020

Monitoring of the state of agricultural crops and forecasting the crops development begin with aerial photography using a unmanned aerial vehicles and a multispectral camera. Vegetation indexes are selected empirically and calculated as a result of operations with values of diff erent spectral wavelengths. When assessing the state of crops, especially in breeding, it is necessary to determine the limiting factors for the use of vegetation indexes.(Research purpose) To analyze, evaluate and select vegetation indexes for conducting operational, high-quality and comprehensive monitoring of the state of crops and the formation of optimal management decisions.(Materials and Methods) The authors studied the results of scientifi c research in the fi eld of remote sensing technology using unmanned aerial vehicles and multispectral cameras, as well as the experience of using vegetation indexes to assess the condition of crops in the precision farming system. The limiting factors for the vegetation indexes research were determined: a limited number of monochrome cameras in popular multispectral cameras; key indicators for monitoring crops required by agronomists. After processing aerial photographs from an unmanned aerial vehicle, a high-precision orthophotomap, a digital fi eld model, and maps of vegetation indexes were created.(Results and discussion) More than 150 vegetation indexes were found. Not all of them were created through observation and experimentation. The authors considered broadband vegetation indexes to assess the status of crops in the fi elds. They analyzed the vegetation indexes of soybean and winter wheat crops in the main phases of vegetation.(Conclusions) The authors found that each vegetative index had its own specifi c scope, limiting factors and was used both separately and in combination with other indexes. When calculating the vegetation indexes for practical use, it was recommended to be guided by the technical characteristics of multispectral cameras and took into account the index use eff ectiveness at various vegetation stages.