bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Physical Activity on Premenstrual Syndrome: A Systematic Review
Authors: Ayyub Sayma , Agrawal Manju , Sharma Vibha , Aravind Arya 
Published: December 2024

Background Physical, emotional, and behavioural symptoms that can significantly impact daily life are the hallmarks of premenstrual syndrome (PMS), a common illness affecting women of reproductive age. There are many different ways to manage PMS, and there is mounting evidence that physical activity may be helpful in reducing symptoms. With an emphasis on different exercise modalities such as weight training, yoga, and aerobic activity, this systematic review attempts to investigate how physical activity affects the management of PMS symptoms. Summary A systematic review of studies published between 2009 and 2023 was conducted, adhering to PRISMA guidelines. Articles from PubMed, Embase, and the Cochrane Library were evaluated based on inclusion criteria focusing on the effects of physical activity on PMS symptoms. The findings indicate that regular participation in exercises such as weight training, yoga, and aerobic activities significantly reduces fatigue, improves mood regulation, and alleviates physical discomfort associated with PMS. These results highlight the benefits of exercise as an effective, non-pharmacological intervention for managing PMS symptoms. Key Messages Incorporating regular physical activity into daily routines can serve as a practical and sustainable approach to managing PMS symptoms. Women suffering from PMS can experience improved physical and psychological well-being through diverse forms of exercise, including yoga and aerobic workouts. This underscores the role of exercise as a holistic and accessible intervention for enhancing women’s health.
Building relationships for shared cases between state and tribal vocational rehabilitation programs
Authors: Boland Elizabeth A , Dagel Wayne W , Emanuel Jamie M , Roberts Kelly D , Beam Kyle W 
Published: December 2024

Background Since their inception, State Vocational Rehabilitation (SVR) and American Indian Vocational Rehabilitation Services (AIVRS) have played pivotal roles in assisting millions of individuals with disabilities in securing and sustaining competitive integrated employment. Objective This article aims to inform readers about the historical context and key issues concerning AIVRS while proposing strategies for enhanced collaboration between AIVRS and SVR programs in joint service provision. Methods While published research on providing VR services to American Indians or Alaska Natives (AI/AN) is limited, much of the information in this article is based on the extensive knowledge of the authors, who collectively possess decades of experience in SVR and AIVRS. Results Key topics include (a) challenges encountered by the AI/AN population; (b) prevailing attitudes toward disability and employment within AI/AN communities; (c) a comparative overview of the histories and operations of SVR and AIVRS; (d) supporters of and advocates for AIVRS projects; (e) considerations when sharing cases; and (f) recommendations for fostering cooperative practices that benefit AI/AN communities. Conclusion By integrating culturally appropriate services, including holistic traditional healing, AIVRS projects and SVR agencies can offer complementary support while honoring the cultural heritage of AI/AN clients.
Factors affecting breastfeeding self-efficacy among mothers with preterm infants
Authors: Nayebinia Anvar-Sadat , Faroughi Farnaz , Asadi GholamReza , Fathnezhad-Kazemi Azita 
Published: December 2024

Background: Although challenges in breastfeeding are more common in mothers of preterm infants, maternal breastfeeding self-efficacy is a modifiable factor that may improve breastfeeding rates. Objective: To evaluate the factors affecting breastfeeding self-efficacy among mothers with preterm babies. Design: A cross-sectional study. Methods: This study was carried out using a double-stage cluster sampling method. In total, 360 mothers of preterm infants under 6 months of age were included. Data were collected using sociodemographic characteristics, Breastfeeding Self-efficacy Scale-Short Form (BSES-SF), multiple scales of perceived social support, and Depression, Anxiety, and Stress questionnaires. Results: The results showed social support (15.6%), depression (12.2%), anxiety (11%), and stress (12.2%) contributed independently, and together they explained 25% of the variance in BSES-SF. The higher levels of social support (β = 0.283), lower levels of mental health problems (β = −0.340), having breastfeeding experience (β = −0.253), and higher gestational age at birth (β = 0.106) were significantly related to the high level of BSES-SF. Conclusion: These findings can help healthcare providers be aware of effective factors in improving breastfeeding self-efficacy. Increased access to counselors, active support for mothers after preterm labor, and increased support facilities for mothers with preterm delivery may be helpful to improve breastfeeding self-efficacy.
Brain invasion by an otherwise benign meningioma in a cat
Authors: Arai Kiyotaka , Nakamura Shinichi , Matsubara Kanami , Ozaki Yuma , Kadekaru Sho , Sugiyama Akihiko , Mitsui Ikki , Akashi Natsuki , Yoshitake Ryohei , Kutara Kenji 
Published: December 2024

Case summary A 13-year-old castrated male American Shorthair cat was referred for evaluation following a 3-week history of poor balance and decreased activity. The MRI findings revealed a well-defined left caudal cerebellar mass with a diameter of 1.2 cm, consistent with a meningioma. CT and MRI scans did not reveal metastasis. After a suboccipital craniotomy, the mass was resected subtotally as a result of parenchymal invasion. A histopathological examination revealed a benign fibrous meningioma with invasion into the cerebellum at the tumour margins. Postoperatively, the cat remained asymptomatic for 25 months, but ataxia recurred, and tumour recurrence was confirmed using MRI and post-mortem examination. Relevance and novel information This case demonstrates that even feline meningiomas with benign features can exhibit brain invasion. Since brain invasion is an indicator of malignancy in meningioma, a detailed histopathological evaluation of the tumour margins is essential for accurate grading and prognosis.
Endovascular stent graft treatment for stenosis in isolated infrarenal abdominal aortic dissection: A case report
Authors: Ohta Kengo , Arahata Risa , Horiba Junji , Kaneko Hitomi , Kondo Kurando 
Published: December 2024

We report a case of complicated isolated infrarenal abdominal aortic dissection (IAAD) that was treated with stent graft. A 79-year-old man presented with acute bilateral lower limb pain. A contrast-enhanced CT performed 2 h later revealed sever stenosis of infrarenal abdominal aorta due to IAAD. Angiography identified a primary tear just below the upper end of the IAAD. A smaller stent graft was placed distally to avoid stent graft–induced new entry, and a large stent graft was placed proximally to cover the primary entry. The stenosis improved immediately after the procedure, and pain relief was achieved. Stent graft placement for entry closure appeared to be an effective for IAAD.
Patient Preferences for Addressing Unhealthy Behaviors, Mental Health Challenges, and Social Needs in Primary Care
Authors: Gilbert Jennifer L. , Brooks Edward Marshall , Funk Adam , Webel Benjamin , Britz Jacqueline , Kelly Cameron , Wilson Jacqueline , Lee Jong Hyung , Sabo Roy T. , Huebschmann Amy , Glasglow Russell E. , Krist Alex H. 
Published: December 2024

Objectives: Guidelines recommend addressing health behaviors, mental health, and social needs in primary care. However, it is unclear how often patients want support to address these risks. As part of a randomized trial comparing enhanced care planning versus usual care, we evaluated what risks patients wanted to address. Methods: All patients with multiple chronic conditions, 1 or more of which was uncontrolled, from 81 clinicians in 30 primary care practices. Using My Own Health Report (MOHR), patients identified and prioritized their health risks to create a care plan. Results: All patients had at least 1 unhealthy behavior (100%) and most had a mental health risk (66.8%) and a social need (51.3%). Participants more often chose to create care plans addressing unhealthy behaviors (92.5%) rather than mental health (23.2%), or social needs (12.5%). The most frequently created care plans were for exercise (65.1%), weight loss (37.2%), and nutrition (36.2%). Conclusion: All patients had 1 or more unhealthy behaviors, mental health risks, or social needs, and were more likely to address health behaviors. We need to better understand these patient choices, and change the culture to normalize the integration of mental health and social care into primary care.
Primary care in rural areas: a qualitative study on medical students’ images and experiences of working in rural areas in southern Germany
Authors: Gehrmann Jan , Barth Niklas , Brandhuber Tom , Berberat Pascal O. , Gigou Sophie , Schneider Antonius 
Published: December 2024

Abstract
Background
Rural areas are increasingly moving back into the focus of social research, especially in the context of health care. As the shortage of general practitioners (GP) in rural areas is a significant challenge in Germany, there are several programs to counteract underuse effectively, acutely, and sustainably. One of those programs is ’Beste Landpartie Allgemeinmedizin’ (BeLA), which was developed to strengthen primary care in rural areas and to sustainably promote young doctors to work as general practitioners in rural regions through didactical and financial support. The program includes an accompanying qualitative study exploring the motivational structures of medical students from a sociological perspective. For this study, the nexus of working in rural areas from the perspective of medical students with different forms of rural experiences was of interest.

Methods
Qualitative interviews have been conducted at regular intervals on an ongoing basis since 2020 to investigate motivational retention effects during the program. The current 33 interviews were analysed using the sociological conceptual framework of spatial methods.

Results
The images and experiences of working in rural areas condition medical education in various ways. In addition to general images of living and working in rural areas in a biographical dimension, the idea of working as a GP in rural areas includes images of specific medical competencies and is conditioned by different medical tasks. From such a perspective, the images and attributions of working in primary care in a rural region demonstrate particularities, challenges, and the potential attractiveness of working in rural regions.

Discussion
The images and experiences of rural areas condition medical education in various ways and shape the expectations and the decision-making of possibly working in rural areas. The particularities, opportunities, and challenges of working in rural areas, which relate to both professional aspects and social life, are a major factor in the attractiveness of a potential rural practice. Didactical and educational curricula need to adapt the various attributions of working in rural areas.
Evidence for in vivo resistance against allopurinol in a dog infected with Leishmania infantum by reduction in copy numbers of the S-adenosylmethionine synthetase (METK) gene
Authors: Schäfer Ingo , Faucher Mathieu , Nachum-Biala Yaarit , Ferrer Lluís , Carrasco Marina , Kehl Alexandra , Müller Elisabeth , Naucke Torsten J. , Baneth Gad 
Published: December 2024

Abstract
Background
In Europe, canine leishmaniasis is commonly caused by Leishmania infantum. Allopurinol is the main drug for long-term management of the disease, and clinical relapses of L. infantum infection treated with this drug are described. Resistance to allopurinol has been demonstrated in-vitro, but there is only little knowledge on in vivo resistance in dogs.

Findings
A two-year-old female spayed Akita Inu that was adopted from a breeding facility near Nice in France was initially diagnosed with primary immune-mediated hemolytic anemia. Immunosuppressive treatment was initiated, and the dog was referred for a second opinion to the Clinique Veterinaire Alliance in France. PCR testing for L. infantum was performed out of EDTA blood and IFA as well as ELISA testing out of serum. Resistance to allopurinol was associated with chromosome and gene copy number (CN) variations including a decrease in the S-adenosylmethionine synthetase (METK) gene CN.

Results
The dog showed pale mucous membranes, fever (39.1 °C), and a relapse of the anemia. The diagnosis of leishmaniasis was based on the cytological finding of Leishmania amastigotes (bone marrow, spleen, liver), positive PCR testing, and positive IFAT serology. The dog was treated with allopurinol over a period of 1316 days and additionally received two cycles of Glucantime® (meglumine antimoniate), before samples were submitted to the LABOKLIN laboratory to test for resistance against allopurinol. The laboratory work-up revealed mild thrombocytopenia, mild hyperproteinemia with hyperglobulinemia, a marked elevation of the c-reactive protein, and decreased iron concentration. Serum protein electrophoresis showed a polyclonal peak in the gamma globulins. Serology was positive in both ELISA (21.5 LE) and IFAT (1:1024). Quantitative PCR testing of blood was positive with low numbers of Leishmania (10/ml blood) at the timepoint of suspicion for resistance. The urinary protein-to-creatinine ratio was markedly elevated (2.5) and xanthine crystalluria was detected. A CN level of below 3 is considered suspicious for resistance, as revealed in the described Akita Inu dog.

Conclusions
Relapse of L. infantum infection after applying allopurinol for 1316 days due to resistance was suspected clinically. Positive PCR testing, consistent hematological and biochemistry abnormalities, and reduction in the METK gene CN backed up the clinical suspicion of resistance. Dogs infected with allopurinol resistant strains of L. infantum may represent a great risk for infection of naïve dogs, cats, and humans.

Graphical Abstract
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
Authors: Weiss Fiona , Hughes Laura , Fu Yuhong , Bardy Cedric , Halliday Glenda M. , Dzamko Nicolas 
Published: December 2024

Abstract
Background
Parkinson’s disease (PD) is characterised by degeneration of ventral midbrain dopaminergic (DA) neurons and abnormal deposition of α-synuclein (α-syn) in neurons. Activation of the innate immune pathogen recognition receptor toll-like receptor 2 (TLR2) is associated with exacerbation of α-syn pathology. TLR2 is increased on neurons in the PD brain, and its activation results in the accumulation and propagation of α-syn through autophagy inhibition in neurons. In addition to the aggregation and propagation of pathological α-syn, dysfunction of astrocytes may contribute to DA neuronal death and subsequent clinical progression of PD. However, the role of astrocytes in TLR2-mediated PD pathology is less explored but important to address, given that TLR2 is a potential therapeutic target for PD.

Methods
Induced pluripotent stem cells from three controls and three PD patients were differentiated into a midbrain model comprised of neurons (including DA neurons) and astrocytes. Cells were treated with or without the TLR2 agonist Pam3CSK4, and α-syn pathology was seeded using pre-formed fibrils. Confocal imaging was used to assess lysosomal function and α-syn pathology in the different cell types, as well as DA neuron health and astrocyte activation.

Results
TLR2 activation acutely impaired the autophagy lysosomal pathway, and potentiated α-syn pathology seeded by pre-formed fibrils in PD neurons and astrocytes, leading to degeneration and loss of DA neurons. The astrocytes displayed impaired chaperone-mediated autophagy reducing their ability to clear accumulated α-syn, and increases of A1 neurotoxic phenotypic proteins SerpinG1, complement C3, PSMB8 and GBP2. Moreover, the phenotypic changes in astrocytes correlated with a specific loss of DA neurons.

Conclusions
Taken together, these results support a role for astrocyte dysfunction in α-syn accumulation and DA neuronal loss following TLR2 activation in PD.
Enhancing Mechanical Properties of Alkali-Activated Slag SIFCON for Sustainable Construction Using Recycled Glass and Tire-Derived Waste Steel Fibers
Authors: Gok Saadet Gokce , Sengul Ozkan 
Published: December 2024

AbstractThis paper presents the outcomes of a study in which continuous steel fibers, recovered from scrap tires of vehicles, were used to prepare alkali-activated slag-based slurry infiltrated fibrous concrete (SIFCON). In this experimental study, the steel fibers used were 250 mm long, with varying fiber contents of 0%, 1%, 2%, 3%, 4%, and 5%. The alkali-activated SIFCONs were produced by activating ground granulated blast furnace slag (GGBS) with a mixture of sodium hydroxide (NaOH) and sodium silicate (Na2SiO3) solutions. Mixtures with ordinary Portland cement (OPC) were also cast for comparison purposes. The feasibility of utilizing finely ground waste glass as a silicate source for chemical activator solution in alkali-activated SIFCONs was also investigated. In this context, two different molar concentrations of NaOH, namely 8 M and 14 M, were employed during production. As activators, one series of mixtures utilized sodium hydroxide and sodium silicate solutions, while the other series replaced sodium silicate with finely ground waste glass. As a result, three different waste materials were utilized in concrete. 30 different mixtures were cast and examined in the experimental study. Load–deflection curves were obtained in three-point bending test and mechanical properties of the mixtures such as compressive, splitting and flexural strengths, fracture energy, and toughness were determined. The flexural strength and toughness increased with the use of waste steel fibers. The continuous waste fibers derived from discarded tires yielded results comparable to commercially available fibers, demonstrating their effectiveness in enhancing mechanical properties. Depending on mix design, the alkali-activated SIFCON attained flexural strength exceeding 75 MPa and compressive strength surpassing 100 MPa. These results suggest that concretes incorporating a variety of waste materials can be effectively combined. This innovative approach bridges an existing gap in the literature by combining alkali activation, waste glass, and waste steel fibers, ultimately yielding a sustainable composite that outperforms normal concretes in terms of mechanical properties while promoting environmental sustainability. Test results demonstrate that it is possible to obtain concrete with comparable mechanical properties while primarily composed of by-products and waste materials. This approach marks a substantial step in achieving high-performance concrete that relies solely on waste or by-products.
Graphical Abstract
Oxidative stress controls lncRNA-mediated sow granulosa cell functions in a FoxO1-dependent manner
Authors: Sheng Wenmin , Wang Miaomiao , Li Yuqi , Sun Zhenyu , Du Xing , Li Qifa 
Published: December 2024

Abstract
Background
Oxidative stress (OS) is involved in low female fertility by altering multi-omics such as the transcriptome, miRome, and lncRNome in follicular cells and follicular fluid. However, the mechanism by which OS affects multi-omics dynamics remains largely unknown. Here, we report that OS induces lncRNome dynamics in sow granulosa cells (sGCs), which is partially dependent on the transcription factor activity of its effector, FoxO1.

Results
A total of 2,283 putative FoxO recognition elements (FREs) were identified in the promoters of 394 lncRNAs, accounting for 91.20% (394/432) of the lncRNAs regulated by OS. ChIP and reporter assays showed that the effector FoxO1 mediated OS regulation of lncRNA transcription in a transcription factor activity-dependent manner. In sGCs, OS induces the transcription and function (e.g., apoptosis) of NORSF (non-coding RNA involved in sow fertility), a nuclear lncRNA involved in sGC function via FoxO1. Furthermore, FoxO1 has been identified as a transcriptional activator of NORSF in sGCs that interacts with the FRE motif of its promoter. Meanwhile, OS downregulates the transcription of CYP19A1, which encodes an essential enzyme for estrogen synthesis and 17β-estradiol (E2) release by sGCs via the FoxO1 and NORSF axis. Phenotypically, dysregulation of NORSF transcription caused by 2 novel adjacent transitions in the promoter leads to decreased sow fertility.

Conclusion
These results suggest a model of OS-stimulated lncRNome dynamics in sGCs and a new signaling pathway of OS that influences sGC function and sow fertility.
The use of XR technology in criminal justice teaching and education: a scoping review
Authors: Meenaghan Amy , van Sintemaartensdijk Iris 
Published: December 2024

AbstractXR technology (an umbrella term that incorporates virtual reality (VR), augmented reality (AR), mixed reality (MR), and in some opinions, 360 immersive video) offers considerable potential for supporting learning in the criminal justice sector. The use of XR can allow students and trainees to experience hard-to-reach, risky and dangerous scenarios, and to safely practice repeated learning in order to develop skills and expertise. Despite this potential, the extent to which XR technology has been introduced into criminal justice education and training is relatively limited. A scoping review was undertaken to assess current applications, areas of strength and limitations in current provision, and to identify recommendations for future XR enhanced educational approaches. The review identified that the use of XR technology was somewhat limited to small, stand-alone simulations. With some exceptions, the application of educational theory was also limited. Efforts to assess the effectiveness of simulations often relied on self-reported measures. The review concludes that there is potential for XR technology to impact criminal justice education and training in a positive way, but this needs to be built on a solid empirical and theoretical foundation.
Enhanced performance of hafnia self-rectifying ferroelectric tunnel junctions at cryogenic temperatures
Authors: Hwang Junghyeon , Kim Chaeheon , Ahn Jinho , Jeon Sanghun 
Published: December 2024

AbstractThe advancement in high-performance computing technologies, including quantum and aerospace systems, necessitates components that operate efficiently at cryogenic temperatures. In this study, we demonstrate a hafnia-based ferroelectric tunnel junction (FTJ) that achieves a record-high tunneling electroresistance (TER) ratio of over 200,000 and decade-long retention characteristics. By introducing asymmetric oxygen vacancies through the strategic use of indium oxide (InOx) layer, we enhance the TER ratio without increasing off-current, addressing the longstanding issue of low on-current in hafnia-based FTJs. Unlike prior approaches that led to leakage currents, our method optimizes tunneling behavior by leveraging the differential oxygen dissociation energy between InOx and hafnium zirconium oxide (HZO). This results in asymmetric modulation of the tunnel barrier, enhancing electron tunneling in one polarization state while maintaining stability in the opposite state. Furthermore, we explore the intrinsic characteristics of the FTJ at cryogenic temperatures, where reduced thermal energy minimizes leakage currents and allows the maximization of device performance. These findings establish a new benchmark for TER in hafnia-based FTJs and provide valuable insights for the integration of these devices into advanced cryogenic memory systems.
Graphical Abstract