bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fijación de invertebrados en tres tipos de substratos artificiales en el estero de Sabancuy, Campeche, Golfo de México
Authors: Torruco Daniel , González-Solís Alicia , Torruco-González Ángel D. 
Published: May 2020

Para los invertebrados sésiles, el comportamiento del asentamiento larval y la selección del substrato final para su fijación es crítico para el posterior desarrollo del organismo adulto. En el presente trabajo se realizó un análisis comparativo de dos temporadas en 2018, y de tres tipos de substratos artificiales: dos de plástico y uno biogénico para la fijación de larvas de organismos en la boca del Estero de Sabancuy de la Laguna de Términos, Campeche. Se realizaron comparaciones entre la longitud y amplitud de la concha de Crassostrea virginica como expresión de crecimiento para esas temporadas y para esos tipos de substrato dada su importancia comercial. El substrato más eficiente en el contexto establecido fue el tipo biogénico (46,78 % del total de las fijaciones), así como la estación dos en ambas épocas (>1000 fijaciones), obteniendo mejores resultados en la segunda época (agosto). El grupo más oportunista fue el de los crustáceos Cirripedios en ambas temporadas. El grupo que presentó mayores fluctuaciones en su frecuencia relativa fueron las esponjas. En ambas temporadas se observó un patrón de tallas semejante para Crassostrea, solo que con un intervalo amplio de variación; por consiguiente, es probable que se favorezca la fijación progresiva de post larvas y permita el establecimiento de tallas pequeñas y el sucesivo crecimiento de las ya existentes
Novel Therapeutic Approaches and Targets for the Treatment of Neutrophilic Dermatoses, Management of Patients with Neutrophilic Dermatoses and Future Directions in the Era of Biologic Treatment
Authors: Molinelli Elisa , Brisigotti Valerio , Paolinelli Matteo , Offidani Annamaria 
Published: May 2020

:
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders characterized
by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. Universally
accepted and validated guidelines for the management of neutrophilic dermatoses do not exist, also
given the paucity of randomized controlled study and high-quality data. However, the literature on the
effective use of biologic therapies is rapidly expanding. This article reviews the epidemiology, clinical
characteristics, histopathologic features, and management of pyoderma gangrenosum as well as
Sweet’s syndrome, sub-corneal pustular dermatoses and bowel-associated dermatosis arthritis syndrome.
The use of biologic agents, including tumor necrosis factor α-inhibitors, anti-IL1, anti-IL-17,
and IL-23 are discussed in detail.
Is It the Twilight of BACE1 Inhibitors?
Authors: Hrabinova Martina , Pejchal Jaroslav , Kucera Tomas , Jun Daniel , Schmidt Monika , Soukup Ondrej 
Published: May 2020

:
β-secretase (BACE1) has been regarded as a prime target for the development of amyloid
beta (Aβ) lowering drugs in the therapy of Alzheimer´s disease (AD). Although the enzyme was
discovered in 1991 and helped to formulate the Aβ hypothesis as one of the very important features
of AD etiopathogenesis, progress in AD treatment utilizing BACE1 inhibitors has remained limited.
Moreover, in the last years, major pharmaceutical companies have discontinued clinical trials of
five BACE1 inhibitors that had been strongly perceived as prospective. In our review, the Aβ hypothesis,
the enzyme, its functions, and selected substrates are described. BACE1 inhibitors are
classified into four generations. Those that underwent clinical trials displayed adverse effects, including
weight loss, skin rashes, worsening of neuropsychiatric symptoms, etc. Some inhibitors
could not establish a statistically significant risk-benefit ratio, or even scored worse than placebo.
We still believe that drugs targeting BACE1 may still hide some potential, but a different approach
to BACE1 inhibition or a shift of focus to modulation of its trafficking and/or post-translational
modification should now be followed.
The Effect of Melatonin Modulation of Non-coding RNAs on Central Nervous System Disorders: An Updated Review
Authors: Lu Jianan , Luo Yujie , Mei Shuhao , Fang Yuanjian , Zhang Jianmin , Chen Sheng 
Published: May 2020

:
Melatonin is a hormone produced in and secreted by the pineal gland. Besides its role in
regulating circadian rhythms, melatonin has a wide range of protective functions in the central
nervous system (CNS) disorders. The mechanisms underlying this protective function are associated
with the regulatory effects of melatonin on related genes and proteins. In addition to messenger
ribonucleic acid (RNA) that can be translated into protein, an increasing number of non-coding
RNAs in the human body are proven to participate in many diseases. This review discusses the
current progress of research on the effects of melatonin modulation of non-coding RNAs
(ncRNAs), including microRNA, long ncRNA, and circular RNA. The role of melatonin in regulating
common pathological mechanisms through these ncRNAs is also summarized. Furthermore, the
ncRNAs, currently shown to be involved in melatonin signaling in CNS diseases, are discussed.
The information compiled in this review will open new avenues for future research into melatonin
mechanisms and provide a further understanding of ncRNAs in the CNS.
MRMD2.0: A Python Tool for Machine Learning with Feature Ranking and Reduction
Authors: He Shida , Guo Fei , Zou Quan , HuiDing  
Published: May 2020

Aims:
The study aims to find a way to reduce the dimensionality of the dataset.

Background:
Dimensionality reduction is the key issue of the machine learning process. It does
not only improve the prediction performance but also could recommend the intrinsic features and
help to explore the biological expression of the machine learning “black box”.

Objective:
A variety of feature selection algorithms are used to select data features to achieve
dimensionality reduction.

Methods:
First, MRMD2.0 integrated 7 different popular feature ranking algorithms with
PageRank strategy. Second, optimized dimensionality was detected with forward adding strategy.

Result:
We have achieved good results in our experiments.

Conclusion:
Several works have been tested with MRMD2.0. It showed well performance.
Otherwise, it also can draw the performance curves according to the feature dimensionality. If
users want to sacrifice accuracy for fewer features, they can select the dimensionality from the
performance curves.

Other:
We developed friendly python tools together with the web server. The users could upload
their csv, arff or libsvm format files. Then the webserver would help to rank features and find the
optimized dimensionality.
Detecting TYMS Tandem Repeat Polymorphism by the PSSD Method Based on Next-generation Sequencing
Authors: He Binsheng , Yang Jialiang , Tian Geng , Bing Pingping , Lang Jidong 
Published: May 2020

Background:
Thymidylate Synthase (TS) is an important target for folic acid inhibitors
such as pemetrexed, which has considerable effects on the first-line treatment, second-line
treatment and maintenance therapy for patients with late-stage Non-Small Cell Lung Cancer
(NSCLC). Therefore, detecting mutations in the TYMS gene encoding TS is critical in clinical
applications. With the development of Next-Generation Sequencing (NGS) technology, the
accuracy of TYMS mutation detection is getting higher and higher. However, traditional methods
suffer from false positives and false-negatives caused by factors like limited sequencing read
length and sequencing errors.

Objective:
A method was needed to overcome the short sequencing read length and sequencing
errors of NGS to make the detection of TYMS more accurate.

Methods:
In this study, we developed a novel method based on "Paired Seed Sequence Distance”
(PSSD) to detect the Variable Number of Tandem Repeat (VNTR) mutation for TYMS.

Results:
With the 121 samples validated by sanger, the consistency rate of PSSD method was
85.95% (104/121), higher than the strict matching method (78.51% (95/121)). The consistency rate
of the two methods was 89.26% (108/121). We also found that the PSSD method was significantly
better than the strict matching method, especially in the 4R typing.

Conclusion:
Our method not only improves the detection rate and accuracy of TYMS VNTR
mutations but also avoids problems caused by sequencing errors and limited sequencing length.
This method provides a new solution for similar polymorphism analyses and other sequencing
analyses.
Immunomodulatory Properties of Chitosan: Impact on Wound Healing and Tissue Repair
Authors: Saini Sapna , Dhiman Anju , Nanda Sanju 
Published: May 2020

Objective:
Chitosan, a natural polymer from shelled crustaceans, has been employed in an
array of biomedical applications as it possesses a combination of fascinating attributes such as biocompatibility,
biodegradability, non-toxicity and ease of chemical alteration into different active derivatives.
The ability of chitosan to be tailored into different shapes has made it a very popular polymer
for designing novel drug delivery systems for topical, transdermal and gene delivery. Recently, the
multifunctional and immunomodulatory properties of chitosan have attracted a lot of attention. Since
there are many patents and publications on medicated scaffolds, films and other topical dressings containing
chitosan, an effort has been made to collate and synchronize the immunomodulatory properties
of chitosan with its wound healing potential.

Methods:
Literature and patent search was done using major search engines and websites. Based on
the studies conducted by various research groups, the information was classified into important subheadings.

Results:
Most of the studies suggested that due to remarkable immuno-stimulatory activities, chitosan
stimulates the release of anti-inflammatory cytokines, chemokines, growth factors and hence promotes
and supports every phase of wound healing, including hemostasis, inflammation, cell migration, proliferation,
tissue repair and cell regeneration.

Conclusion:
An understanding of the immunomodulatory activities of chitosan can help the researchers
and formulation scientists to use this natural polymer and its derivatives to design controlled release,
medicated, self–decomposable, environment-friendly scaffolds for better patient compliance and
promising wound-healing effects.
Impact of Interleukin 28B and ICAM-1 Genetic Polymorphisms on Response to Direct Antiviral Treatment Among HCV Infected Patients
Authors: Elsheredy Amel G. , Almaeen Abdulrahman H. , Ghazy Amany A. , Helaly Ghada F. , Amer Ibrahim , Ghazy Haneen A. , Haydara Tamer 
Published: May 2020

Background:
Single nucleotide polymorphisms (SNPs) of IL-28B and/or ICAM-1 could
have a role in expecting a response from HCV infected patients to direct antiviral agents (DAAs).

Objective:
The aim of the current study was to investigate the impact of IL-28B rs12979860 and
rs8099917, and, ICAM-1 rs281437 SNPs on response to treatment with sofosbuvir + Daclatsvir ± Ribavirin,
among HCV-infected Egyptian patients.

Methods:
Whole blood genomic DNA was extracted from 120 participants (80 HCV-infected patients
and 40 healthy volunteers). HCV-infected patients were subdivided into responders and nonresponders
to DAAs. Liver function testing, anti-HCV antibodies, HCV-RNA viral load and HCV
genotyping were performed. IL-28B and ICAM-1 SNPs were evaluated by real-time PCR.

Results:
ALT and AST levels were significantly higher among non-responder HCV infected patients
(P = 0.001*). 90% of the patients had HCV genotype 4a and the remaining 10% had 4l genotype. Allelic
discrimination revealed that IL-28B rs12979860 T, IL-28B rs809917 T and ICAM-1 rs281437 C
alleles were more frequent among HCV-infected patients (responders or non-responders) than controls.
However, IL-28B rs8099917 G allele was more frequent among healthy controls. Regarding the response
to DAAs treatment, HCV-infected patients with IL-28B rs8099917 GG genotype showed a
significantly earlier viral response compared to those carrying TT alleles. ICAM-1 rs281437 CT alleles
were non significantly more frequent among responders. However, IL-28B rs12979860 alleles did not
show any difference.

Conclusion:
Genotyping of IL-28B rs8099917 is a useful independent tool for expecting a response of
Egyptian HCV-infected patients to DAAs.
IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran
Authors: Asgharzadeh Mohammad , Najafi-Ghalehlou Nima , Poor Behroz M. , Asgharzadeh Vahid , Pourostadi Mahya , Vegari Ali , Kafil Hossein S. , Fadaee Manouchehr , Farhoudi Mehdi , Rashedi Jalil 
Published: May 2020

Background:
Cytokines are polypeptides that play critical roles in immune responses. Gene
polymorphisms occurring in the inflammatory cytokines are taking a role in autoimmune diseases,
including multiple sclerosis (MS), which may induce inappropriate immune responses.

Objective:
The aim of this study was to investigate the allelic and genotypic frequencies of interferon
gamma gene (IFN-γ) at +874A/T locus and tumor necrosis factor (TNF-α) at+308A/G locus in MS
patients of Azeri population.

Methods:
At first, a questionnaire was prepared for each of 240 healthy, non-relative, and 152 Azeri
MS patients before obtaining the blood sample from all subjects. After DNA extraction, the frequency
of alleles and genotypes of the IFN-γ and TNF-α genes at +874A/T and -308G/A loci, respectively,
were determined by allele-specific PCR method. Finally, the frequencies were compared between control
and MS patients by chi-square test (x2-test) and p<0.05 was considered significant.

Results:
In the IFN-γ +874A/T gene single nucleotide polymorphism (SNP), the most allelic and genotypic
frequencies in MS patients were the A allele, 55.26% (p=0.04) and the AT genotype, 52.63%
(p=0.048). In healthy individuals, it was 65.42% for the A allele and 45.42% for the AA genotype. For
the TNF-α 308 G/A SNP, the highest allelic and genotypic frequencies in MS patients were the G allele
with 55.92% (p<0.001) and AG genotype with 61.84%, and in healthy subjects, the allelic and
genotypic frequencies were 84.2% and 70.8% for the G allele and GG genotype, respectively.

Conclusion:
Head trauma, the infection with the herpes virus and Mycoplasma pneumonia, frequent
colds and high consumption of canned foods provide grounds for MS. The T allele in the IFN-γ gene
(+874) and the genotypes of AA and AG at the TNF-α gene (-308) at the position-308 were considered
as potential risk factors for MS. Therefore, the polymorphisms in cytokine genes and following
changes in their expression levels can be effective in susceptibility to MS.
Uso, mantenimiento y éxito de la movilización legal en torno a la presa El Zapotillo
Authors: Ruiz Ortega Rafael 
Published: May 2020

<p><span class="fontstyle0">El objetivo central de este trabajo es aportar evidencia empírica y teórica en el estudio de la movilización legal a través del análisis de un conflicto social acaecido en México, en el que una de las partes ha recurrido a diversos recursos jurídicos en conjunto con otras tácticas de movilización política y de acción directa. La metodología consistió en la aplicación de entrevistas semiestructuradas a actores clave y el análisis cualitativo de la información recabada. Este artículo estuvo guiado por dos preguntas centrales: </span><span class="fontstyle2">1) </span><span class="fontstyle0">¿por qué se recurrió a la movilización legal? y </span><span class="fontstyle2">2) </span><span class="fontstyle0">¿qué explica que hayan logrado tener éxito al obtener una resolución jurídica favorable en torno a sus demandas? Algunas conclusiones apuntan a que, si bien el uso y éxito de la movilización legal estuvo precedido por una importante estructura de apoyo interna y externa, también se encontraron otros elementos igualmente relevantes como el sentimiento de injusticia, el cual desató el proyecto, las alianzas estratégicas establecidas por los opositores, el contexto político, la conjunción de diferentes tácticas de movilización, entre otros.</span></p>
Movilización legal y el inicio de la lucha contra la megaminería en México. Del FAO a la REMA
Authors: Martínez Romero Ulises Pavel 
Published: May 2020

<span class="fontstyle0">Este trabajo busca abonar a la creciente discusión sobre el uso de la movilización por parte de grupos organizados para lograr sus objetivos, entendiendo los recursos como un factor fundamental para llevarla a cabo, sostenerla y lograr el éxito. Al mismo tiempo, se aproxima a uno de los problemas más importantes en América Latina: los conflictos generados por megaproyectos, específicamente por la megaminería. La pregunta central que lo orienta es ¿cómo el Frente Amplio Opositor a Minera San Xavier (FAO) mantuvo el uso de la movilización legal? Para dar cuenta de ello, a lo largo del texto se contextualiza y explica el proceso de movilización de este movimiento social poniendo especial énfasis en la movilización legal. A partir del análisis de información primaria y secundaria, se sostiene que el FAO incursionó en la movilización legal sin la ayuda de una </span><span class="fontstyle2">estructura de apoyo </span><span class="fontstyle0">sólida y que, en cambio, el movimiento fue construyendo su propia estructura de apoyo en la que el papel de los abogados fue piedra angular, de manera tal que se dio un proceso de </span><em><span class="fontstyle2">embedded legal activity</span></em><span class="fontstyle0">.</span> <br /><br />
Relationship between macronutrient intake and physical activity with fitness on employees in Pandeglang Hospital
Authors: Rahmawati Silvia Dwi 
Published: May 2020

ABSTRACT
Physical fitness is the ability of one's body to do daily work without causing significant fatigue. Several factors related to fitness are nutritional status, level of physical activity, intake of macro nutrients, genetic makeup, age, sex, health status. The purpose of this study was to analyze the relationship between the level of energy sufficiency and macro nutrients, the level of physical activity with the level of fitness in Pandeglang District Hospital employees. The study design was cross sectional with 75 respondents and used a chi-square analysis test. There is no relationship between the level of energy sufficiency (p-value 1,000) the level of protein sufficiency (p-value 1,000), the level of fat sufficiency (p-value 1,000), the level of carbohydrate adequacy (p-value 0.768) with the fitness level of employees of Pandeglang District Hospital. There is a relationship between physical activity (p-value 0,000) with the fitness level of employees of Pandeglang District Hospital. Employees who have a sufficient level of energy and macro nutrients are on average have a less fitness level. Employees who have a mild level of physical activity tend to have less fitness. So it is necessary to monitor food intake, and the level of physical activity on employees.
Keywords: Macro Nutrition Intake, Physical Activity, Fitness Level
Comunidade aprendente de professores que ensinam Matemática nos anos iniciais: uma experiência formativa
Authors: Mumbach Simone , Guidotti Charles dos Santos 
Published: May 2020

Este artigo apresenta a experiência formativa de uma comunidade aprendente de professores que ensinam Matemática nos Anos Iniciais no intuito de estudar, discutir, refletir e compreender as mudanças curriculares propostas pelo Referencial Curricular Gaúcho de Matemática para esta etapa da escolaridade. A proposição formativa fundamenta-se teoricamente nos entendimentos de comunidade aprendente (BRANDÃO, 2005; GALIAZZI et al., 2017; FREITAS, 2010). A comunidade de professores em formação desenvolveu atividades formativas de forma síncrona e assíncrona, por meio do Google Sala de Aula, totalizando 40 horas. A partir dessa experiência, assumimos que a formação continuada de professores em comunidade oportuniza discussões, reflexões e partilha de experiências possibilitando o aperfeiçoamento da ação docente.
Palavras-chave: Comunidade aprendente. Formação continuada de professores. Matemática. Anos Iniciais. Currículo.
The bio-flavanoid concentrate of Vitis vinifera L. ‘Red Aladasturi’
Authors: Kopaliani Roland , Gvinianidze Temur , Jabnidze Rezo 
Published: May 2020

This paper dwells on the uvological characteristics of cultivar Vitis vinifera L. ‘Red Aladasturi’ grape raw materials growing in the viticulture and winemaking zone of Imereti (Georgia), as well as biologically active compounds and antioxidant activity of hydrophilic extracts and liquid concentrates of its solid matters (stone and skin). Research also covered hydrophilic extracts of grape skin and stone thickened by the vacuum of ‘Red Aladasturi’ grapes raw materials, as well as the concentrates produced from their composition. For research, there were used gravimetric, extractive, spectral and chromatographic methods. We processed samples of grapes raw materials according to the following pattern: identifying qualitative indicators of grapes raw materials; passing grapes raw materials through the DMCSI-type grape clustercomb divider; pressing-out the combless must in a basket press and separation of juice; vacuum sublimation drying of juiceless sweet pomace with an initial moisture content of 45–65% to a final moisture content of 9–10%; separation of the ‘Red Aladasturi’ cultivar’s skin and stone dried to the moisture content of 9–10%, using tea sorting machine designed by G. Lominadze; crushing separately the skin and stone in a micro-mill (TP2 Hammer Mill) until the fraction of 50–100 µm. we have blended the obtained grape-stone ethanol and fluid extracts containing 74–75% of solid maters at an equal ratio (1:1:1) and assessed biologically active compounds and antioxidant activity in this composition. It has been established that the bio-flavanoid liquid concentrate ‘Red Aladasturi’ is strong antioxidant (55.31–57.45%), and one tablespoon or 8–9 ml of it contains 110–127 mg of flavanoids, which is 105–110% of a full day of rations per person per day.
Using RAPD markers for genetic analysis in Three Species of Datura in Iraq
Authors: Amir Altiaee Lubna , H ALassi Akeel , A. Zahwan Thammer 
Published: May 2020

The study amis to develop the evidence genetic of active substances for several kinds of the Datura plant (Datura sp.), So it was procedure steps to isolated the Genomic DNA from leaf of Datura specis it is (Datura metel, Datura innoxia and Datura stramonium).(
Has been used 51 primers in the experiments of the RAPD markers, but did not show 17 primers including any amplified band while showed in genomic in Datura plants, and 34 primers show results Differentiated locations where all the primers gave a differentiated binds Polymorphic band These results have been invested to study genetic variability among the species involved in study.

http://dx.doi.org/10.25130/tjps.23.2018.165
Fabrication and study of the structural and spectral properties of the composites (y) Mn0.6 Zn0.4 Fe2O4 + (1-y) PZT prepared by the powder technology method
Authors: K. Jasem1 Ismaeal , Fawzi Abdul-Aziz2 Abdul-Samee , Malallah Ibrahim1 Nibras 
Published: May 2020

Ferrite-ferroelectric composites holds following chemical formula (y) Mn0.6 Zn0.4 Fe2O4 + (1-y) PZT with different weight rations (y=0.15, 0.30 and 0.45) are prepared by the powder technology method at annealing temperature (1000 °C) for (12hrs). The structural properties are also studied representing by the lattice constants (a, c), particle size (Dt), apparent density (ρa), and X-ray density (ρx). It has been shown that increasing the concentration of the ferrite phase contributes to an increase in the lattice constant, apparent density and X-ray density which in turn contribute in decreasing porosity that plays a role in improving the physical properties of the samples as well as the weight ratios of the mixture after the final sintering with reference to x-ray diffraction technique. In addition, the spectral properties were also studied represented by the vibration force constant and regions of optical absorption in terms of IR technique.

http://dx.doi.org/10.25130/tjps.23.2018.174