bluuebunny/crossref_metadata_2025_split huggingface dataset:
The number of glutamines in the N‐terminal of the canine androgen receptor affects signalling intensities
Authors: Ochiai Kazuhiko , Sutijarit Samak , Uemura Mitsuki , Morimatsu Masami , Michishita Masaki , Onozawa Eri , maeda Marika , Sasaki Takanori , Watanabe Masami , Tanaka Yoshikazu , Omi Toshinori 
Published: November 2020

AbstractMost male dogs are castrated at young ages, making them easy to rear following androgen deprivation. Although the incidence of canine prostate cancer is low, several patients have resistance to androgen therapy and poor clinical prognosis. These outcomes are similar to those of end‐stage human androgen‐independent prostate cancer. The androgen receptor (AR) of canines has two polyglutamine (polyQ) sequences (Q × 10 and Q × 23) at its N‐terminal. The length of polyQ may be a risk factor for the development of prostate cancer in dogs; however, there is no evidence to support this. Hence, we artificially created polyQ deletion mutants of canine AR and evaluated their effects on AR signalling. The deletions of Q × 10 and Q × 23 were associated with significant reductions in AR signalling intensities. The Q × 10 mutants, which increase or decrease Q sequentially, also altered AR signalling. Furthermore, the Q × 10 deletion mutant, compared with the Q × 10 control, altered the intensities of the binding of polyQ to the C‐terminal of AR, which contains a ligand‐binding domain; this was not observed with the Q × 9, 11, and 12 variants. The number of glutamines in the N‐terminals of canine ARs may influence AR signalling intensities and contribute to the risk of prostate cancer in dogs.
Are You Feeling Me? An Exploration of Empathy Development in Engineering Design Education
Authors: Alzayed Mohammad Alsager , McComb Christopher , Menold Jessica , Huff Jacquelyn , Miller Scarlett R. 
Published: November 2020

AbstractHaving empathy in the design process can help engineers relate to the end-user by identifying what and why certain experiences are meaningful. While there have been efforts to identify the factors that impact empathic tendencies in engineering, there has been limited evidence on how a students’ trait empathy or empathic self-efficacy develops over a design project or what factors impact this development. The current study was developed to explore the development of students’ trait empathy and empathic self-efficacy development and identify the underlying impact of the design project’s context and course instructor through a study with 103 engineering students. Students’ trait empathy and empathic self-efficacy were measured across each of the four design stages (problem formulation, concept generation, concept selection, and final conceptual design) during an 8-week project. The results highlight that students’ trait empathy and empathic self-efficacy did not increase across design stages and the context of the design problem did not impact students’ empathy development. Meanwhile, students displayed lower empathic self-efficacy in one of the course sections, and interviews with the course instructors revealed that the lack of accessibility to the end-user might have constricted students from developing empathy. These insights call for future research that could empirically assess the impact of trait empathy and empathic self-efficacy in driving design outcomes in the later design stages, which could increase engineering educators’ awareness of the role of empathy in the engineering classroom.
Improvement of Steels' Corrosion Resistance in Liquid Lead and Lead-Bismuth by Coatings—Review
Authors: Pazderová M. , Rozumová L. , Košek L. , Hojná A. 
Published: November 2020

Abstract
Heavy liquid metal (HLM) cooled systems are under wide investigation and development. The technology needs to study the materials corrosion, which has a different progress than corrosion caused by aqueous media. Improvement of the corrosion resistance can be achieved by alloying the bare material, but the degradation of steels continues with less or more intensity. Deposition of protective barrier may reduce the metals dissolution and diffusion of liquid lead into the steel substrate. Different types of surface treatment and coatings composition were evaluated to find out the most convenient solution for the steel's protection.
Manipulating Users’ Trust of Autonomous Products With Affective Priming
Authors: Liao Ting , MacDonald Erin F. 
Published: November 2020

AbstractAutonomous products, which perform many functions on their own with limited user input, require users to exhibit trust at an appropriate level before use. Research in product trust has thus far focused on the product characteristics: such as manipulating the product’s design—for example, anthropomorphizing an autonomous vehicle—and measuring changes in the users’ trust. This study flips the usual approach and instead manipulates users’ mental state through priming, and then measures users’ trust to an existing autonomous product, the Amazon Echo. In this study, we used visual stimuli (images) that evoked either positive or negative emotions as affective primes to influence users’ trust before interacting with the Echo. While interacting with the Echo, users evaluated its performance and how well it met their expectations. Holistically, users’ perceived performance of the Echo and age had significant effects on their trust of the product, but the affective primes showed no significant effect. However, for the subgroup of participants whose expectations of the product's performance were met: those who received either positive or negative prime were more likely to trust the product than those who saw neutral images; men were more likely to trust the product than others. The study demonstrates the importance of meeting users’ expectations and highlights the potential to build trust by inducing emotions contextually.
The Potential of a Multifidelity Approach to Gas Turbine Combustor Design Optimization
Authors: Toal David J. J. , Zhang Xu , Keane Andy J. , Lee Chin Yik , Zedda Marco 
Published: November 2020

Abstract
The desire to reduce gas turbine emissions drives the use of design optimization approaches within the combustor design process. However, the relative cost of combustion simulations can prohibit such optimizations from being carried out within an industrial setting. Strategies which can significantly reduce the cost of such studies can enable designers to further improve emissions performance. This paper investigates the application of a multifidelity surrogate modeling approach to the design optimization of a typical gas turbine combustor from a civil airliner engine. Results over three different case studies of varying problem dimensionality indicate that a multifidelity surrogate modeling-based design optimization, whereby the simulation fidelity is varied by adjusting the coarseness of the mesh, can indeed improve optimization performance. These results indicate that such an approach has the potential to significantly reduce design optimization cost while achieving similar, or in some cases superior, design performance.
Longitudinal effects of breast feeding on parent-reported child behaviour
Authors: Speyer Lydia Gabriela , Hall Hildigunnur Anna , Ushakova Anastasia , Murray Aja Louise , Luciano Michelle , Auyeung Bonnie 
Published: November 2020

Objective
Shorter breastfeeding duration has been linked to a range of difficulties in children. However, evidence linking shorter breastfeeding duration to child behavioural problems has been inconclusive. Owing to an almost exclusive focus on early childhood in previous research, little is known about breastfeeding effects on behaviour throughout childhood and adolescence. This study examines the longitudinal effect of breast feeding on parent-reported behaviour in children aged 3–14.

Design
Data come from the Millennium Cohort Study, a large, prospective, UK birth cohort study.

Participants
11 148 children, their parents and teachers.

Methods
This study maps the effect of breastfeeding duration on parent-reported child behaviour longitudinally, using latent growth curve modelling and on teacher-reported child behaviour using multiple regression analyses. Breastfeeding duration was assessed through parent interviews when the child was 9 months old. Children’s behavioural development was measured using parent-reported Strengths and Difficulties Questionnaires (SDQ) at 3, 5, 7, 11 and 14 years and teacher-reported SDQs at 7 and 11 years.

Results

Breast feeding was associated with fewer parent-reported behavioural difficulties at all ages even after adjusting for potential confounders (<2 months:
B
=−0.22, 95% CI −0.39 to −0.04; 2–4 months:
B
=−0.53, 95% CI −0.75 to −0.32; 4–6 months:
B
=−1.07, 95% CI −1.33 to −0.81; >6 months:
B
=−1.24, 95% CI −1.44 to −1.04;
B
=adjusted mean difference of raw SDQ scores at age 3, reference: never breast fed).

Conclusion
This study provides further evidence supporting links between breastfeeding duration and children’s socioemotional behavioural development. Potential implications include intervention strategies encouraging breast feeding.
Corneal tomographic changes during corneal rigid gas-permeable contact lens wear in keratoconic eyes
Authors: Koh Shizuka , Inoue Ryota , Maeda Naoyuki , Oie Yoshinori , Jhanji Vishal , Miki Atsuya , Nishida Kohji 
Published: November 2020

Background/AimsWe aimed to investigate the refractive changes in the posterior corneal surface in keratoconus (KC) associated with wearing spherical corneal rigid gas-permeable contact lenses (corneal GPs) with apical touch or three-point touch fitting and the effect of spherical corneal GPs on corneal biomechanics.MethodsPatients with KC wearing corneal GPs every day without facing complications were enrolled as a single group. Corneal tomographic data were obtained using a three-dimensional anterior segment optical coherence tomography from the same eye with and without corneal GPs. Dioptric data from the central 3-mm zone of the posterior corneal surface were decomposed into spherical, regular astigmatism, asymmetry and higher-order irregularity components using Fourier harmonic analysis. The corneal biomechanical indices were deformation amplitude ratio within 2 mm, integrated radius, stiffness parameter at first applanation and linear Corvis Biomechanical Index. Correlations between the difference in Fourier indices with and without corneal GPs and the corneal biomechanical parameters were analysed.ResultsThirty-two eyes of 32 patients with KC were enrolled. Spherical, regular astigmatism and asymmetry components were significantly smaller with corneal GP wear than without the wear (all p<0.001). All biomechanical indices were significantly correlated with the difference in the spherical components with and without corneal GPs.ConclusionCorneal biomechanical properties of KC were correlated with posterior corneal surface flattening induced by wearing corneal GPs on the spherical components. This effect is greater in biomechanically weaker corneas.
Geographical disparities in the prognosis of patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a large institution-based cohort study from an endemic area
Authors: Lin Si-Ting , Meng Dong-Fang , Yang Qi , Wang Wei , Peng Li-Xia , Zheng Li-Sheng , Qiang Yuan-Yuan , Mei Yan , Xu Liang , Li Chang-Zhi , Peng Xing-Si , Hu Hao , Lang Yan-Hong , Liu Zhi-Jie , Wang Ming-Dian , Li Hai-Feng , Huang Bi-Jun , Qian Chao-Nan , Sun Rui 
Published: November 2020

ObjectivesGeographical disparities have been identified as a specific barrier to cancer screening and a cause of worse outcomes for patients with cancer. In the present study, our aim was to assess the influence of geographical disparities on the survival outcomes of patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT).DesignCohort study.SettingGuangzhou, China.ParticipantsA total of 1002 adult patients with NPC (724 males and 278 females) who were classified by area of residence (rural or urban) received IMRT from 1 January 2010 to 31 December 2014, at Sun Yat-sen University Cancer Center. Following propensity score matching (PSM), 812 patients remained in the analysis.Main outcome measuresWe used PSM to reduce the bias of variables associated with treatment effects and outcome prediction. Survival outcomes were estimated using the Kaplan-Meier method and compared by the log-rank test. Multivariate Cox regression was used to identify independent prognostic factors.ResultsIn the matched cohort, 812 patients remained in the analysis. Kaplan-Meier survival analysis revealed that the rural group was significantly associated with worse overall survival (OS, p<0.001), disease-free survival (DFS, p<0.001), locoregional relapse-free survival (LRRFS, p=0.003) and distant metastasis-free survival (DMFS, p<0.001). Multivariate Cox regression showed worse OS (HR=3.126; 95% CI 1.902 to 5.138; p<0.001), DFS (HR=2.579; 95% CI 1.815 to 3.665; p<0.001), LRRFS (HR=2.742; 95% CI 1.359 to 5.533; p=0.005) and DMFS (HR=2.461; 95% CI 1.574 to 3.850; p<0.001) for patients residing in rural areas.ConclusionsThe survival outcomes of patients with NPC who received the same standardised treatment were significantly better in urban regions than in rural regions. By analysing the geographic disparities in outcomes for NPC, we can guide the formulation of healthcare policies.
Prevalence and predictors of gestational diabetes mellitus in rural Assam: a cross-sectional study using mobile medical units
Authors: Chanda Subrata , Dogra Vishal , Hazarika Najeeb , Bambrah Hardeep , Sudke Ajit Kisanrao , Vig Anupa , Hegde Shailendra Kumar 
Published: November 2020

ObjectiveTo determine the prevalence and predictors of gestational diabetes mellitus (GDM) in rural Assam, India using a network of Mobile Medical Units.Study designA field-based cross-sectional study.SettingsRural areas of Assam state, India.ParticipantsA total of 1410 pregnant women in gestational age of 24–28 weeksInterventionIdentification of pregnant women in 24–28 weeks of pregnancy from villages and administering them Government of India recommended oral glucose tolerance test for GDM confirmation.Primary and secondary outcome measuresPresence of gestational diabetes among pregnant women, risk factors and predictors of GDM.ResultsA total of 1212 pregnant women underwent the oral glucose tolerance test. One hundred and ninety-eight women were ineligible due to existing chronic diseases or very high blood glucose level before the test. The overall GDM prevalence in Assam was 16.67% (95% CI 14.61% to 18.89%). Women aged 26–30 years (adjusted odds ratio, aOR 1.70; CI 1.14 to 2.52), who passed 10th class (aOR 1.58; CI 1.05 to 2.37), belonging to Muslim religion (aOR 1.52; 95% CI 1.05 to 2.21) and above poverty line (aOR 1.38; 95% CI 1.00 to 1.91) had significantly increased likelihood of developing GDM compared with respective baseline groups (p<0.05). Body mass index, gravida and being non-anaemic were non-significant risk factors for GDM. Family history of diabetes (aOR 1.82; 95% CI 1.08 to 3.06) and smoking (aOR 1.61; 95% CI 1.10 to 2.35) were significant and independent predictors of GDM.ConclusionThe prevalence of GDM in rural Assam is high. The mobile medical units may play a significant role in the implementation of GDM screening, diagnosis, treatment to ensure better maternal and foetal health outcomes in rural Assam.
Use of technology in supporting goal setting in rehabilitation for adults: a scoping review
Authors: Strubbia Carla , Levack William Mark Magnus , Grainger Rebecca , Takahashi Kayoko , Tomori Kounosuke 
Published: November 2020

ObjectiveTo map the extant literature evaluating the use of technology for goal setting in adult rehabilitation and the impact of technology for patient outcomes.DesignScoping review.MethodsMEDLINE (via Ovid), CINAHL (via EBSCO), AMED and Scopus were searched for articles describing observational or interventional studies. ProQuest Dissertations and Theses database were searched for grey literature. Two review authors independently screened all titles and abstracts for potentially relevant articles. We included articles describing studies that had evaluated the development or application of technology to facilitate goal setting in rehabilitation for adults. Articles were excluded if the technology described did not include features to facilitate goal setting or were not in English. Narrative reviews, opinion pieces and editorials were also excluded.ResultsAfter screening 1640 publications of potential interest, we identified 27 studies for inclusion. These 27 articles described studies involving a total of 16 different technologies including, seven mobile apps, three websites, two mobile apps/website hybrids, two apps and two websites connected to a pedometer. We found that most technologies described were designed to facilitate self-management with goal setting as a feature and that only five included a shared decision moment around goal setting. Only six of the 16 technologies had research providing evidence of effectiveness in terms of improved patient outcomes, with the best evidence of beneficial effects associated with technologies that linked goal setting to pedometer use.ConclusionsThe identified technologies for use in adult rehabilitation that included goal setting as a feature were largely accepted and valued by patients and health professionals. The limited data suggest that there is a need for further research; specific foci may include the impact of incorporation of a shared decision-making moment and evaluation of effectiveness on patient outcomes.
Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell)
Authors: Waite Felicity , Kabir Thomas , Johns Louise , Mollison Jill , Tsiachristas Apostolos , Petit Ariane , Černis Emma , Maughan Daniel , Freeman Daniel 
Published: November 2020

BackgroundEffective interventions, targeting key contributory causal factors, are needed to prevent the emergence of severe mental health problems in young people. Insomnia is a common clinical issue that is problematic in its own right but that also leads to the development and persistence of psychotic experiences. The implication is that treating sleep problems may prevent the onset of psychosis. We collected initial case series data with 12 young people at ultra-high-risk of psychosis. Post-intervention, there were improvements in sleep, depression and psychotic experiences. Now we test the feasibility of a randomised controlled trial, with a clinical aim to treat sleep problems and hence reduce depression, psychotic experiences, and prevent transition to psychosis.Methods and analysisA randomised controlled feasibility trial will be conducted. Forty patients aged 14 to 25 years who are at ultra-high-risk of psychosis and have sleep disturbance will be recruited from National Health Service (NHS) mental health services. Participants will be randomised to receive either a novel, targeted, youth-focussed sleep intervention in addition to usual care or usual care alone. Assessor-blinded assessments will be conducted at baseline, 3 months (post-intervention) and 9 months (follow-up). The eight-session psychological intervention will target the key mechanisms which disrupt sleep: circadian rhythm irregularities, low sleep pressure, and hyperarousal. To gain an in-depth understanding of participants’ views on the acceptability of the intervention and study procedures, 16 participants (n=10 intervention, n=6 control) will take part in qualitative interviews. Analyses will focus on feasibility outcomes (recruitment, retention, and treatment uptake rates) and provide initial CI estimates of intervention effects. Thematic analysis of the qualitative interviews will assess the acceptability of the intervention and trial procedures.Ethics and disseminationThe trial has received ethical approval from the NHS Health Research Authority. Findings will be disseminated through peer-reviewed publications, conference presentations, and lay networks.Trial registration numberISRCTN85601537.
Injury surveillance in elite field hockey: a pilot study of three different recording techniques
Authors: Levi Anna , Theilen Till-Martin , Rolle Udo 
Published: November 2020

ObjectiveIn field hockey, injuries are assessed by various recording techniques leading to a heterogenic collection of poorly comparable injury data.MethodsInjury data were prospectively collected at the 2016 Men’s Hockey Junior World Cup using the match injury reports (MIRs), video injury clips provided by the Fédération Internationale de Hockey, and daily medical reports (DMRs). A pilot study comparing injury type, mechanism, location on the field, injured body part and overall injury incidence among the different injury recording techniques was performed.ResultsMIRs and video injury clips were completely available for analysis. DMRs were returned from 11 out of 16 teams (69%). In total, MIRs yielded 28, video analysis 36, and DMRs 56 injuries. Overall injury rate varied between 24.8 and 57.9 injuries per 1000 player match hours. The majority of injuries affected the lower limbs by all three methods (41.7–61.2%) and were mainly caused by having been hit by the ball (20.4–50%) or stick (11.1–28.6%). Reports of concussions during competition were incoherent between MIR (2 cases) and DMR (no cases). The DMR was the only method to record overuse injuries (16.1%), injuries in training (12.5%), and time-loss injuries of one or two days (12.5%) or of three or more days (14.3%).ConclusionInjury data vary substantially between the MIR, DMR and injury video recording technique. Each recording technique revealed specific strengths and limitations. To further advance injury research in field hockey, the strengths of each recording technique should be brought together for a synergistic injury assessment model.
Piecemeal cold snare polypectomy versus conventional endoscopic mucosal resection for large sessile serrated lesions: a retrospective comparison across two successive periods
Authors: van Hattem W Arnout , Shahidi Neal , Vosko Sergei , Hartley Imogen , Britto Kaushali , Sidhu Mayenaaz , Bar-Yishay Iddo , Schoeman Scott , Tate David James , Byth Karen , Hewett David G , Pellisé María , Hourigan Luke F , Moss Alan , Tutticci Nicholas , Bourke Michael J 
Published: November 2020

ObjectiveLarge (≥20 mm) sessile serrated lesions (L-SSL) are premalignant lesions that require endoscopic removal. Endoscopic mucosal resection (EMR) is the existing standard of care but carries some risk of adverse events including clinically significant post-EMR bleeding and deep mural injury (DMI). The respective risk-effectiveness ratio of piecemeal cold snare polypectomy (p-CSP) in L-SSL management is not fully known.DesignConsecutive patients referred for L-SSL management were treated by p-CSP from April 2016 to January 2020 or by conventional EMR in the preceding period between July 2008 and March 2016 at four Australian tertiary centres. Surveillance colonoscopies were conducted at 6 months (SC1) and 18 months (SC2). Outcomes on technical success, adverse events and recurrence were documented prospectively and then compared retrospectively between the subsequent time periods.ResultsA total of 562 L-SSL in 474 patients were evaluated of which 156 L-SSL in 121 patients were treated by p-CSP and 406 L-SSL in 353 patients by EMR. Technical success was equal in both periods (100.0% (n=156) vs 99.0% (n=402)). No adverse events occurred in p-CSP, whereas delayed bleeding and DMI were encountered in 5.1% (n=18) and 3.4% (n=12) of L-SSL treated by EMR, respectively. Recurrence rates following p-CSP were similar to EMR at 4.3% (n=4) versus 4.6% (n=14) and 2.0% (n=1) versus 1.2% (n=3) for surveillance colonoscopy (SC)1 and SC2, respectively.ConclusionsIn a historical comparison on the endoscopic management of L-SSL, p-CSP is technically equally efficacious to EMR but virtually eliminates the risk of delayed bleeding and perforation. p-CSP should therefore be considered as the new standard of care for L-SSL treatment.