bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural responses to social evaluative threat in the absence of negative investigator feedback and provoked performance failures
Authors: Fehlner Phöbe , Bilek Edda , Harneit Anais , Böhringer Andreas , Moessnang Carolin , Meyer‐Lindenberg Andreas , Tost Heike 
Published: January 2020

AbstractFunctional neuroimaging of social stress induction has considerably furthered our understanding of the neural risk architecture of stress‐related mental disorders. However, broad application of existing neuroimaging stress paradigms is challenging, among others due to the relatively high intensity of the employed stressors, which limits applications in patients and longitudinal study designs. Here, we introduce a less intense neuroimaging stress paradigm in which subjects anticipate, prepare, and give speeches under simulated social evaluation without harsh investigator feedback or provoked performance failures (IMaging Paradigm for Evaluative Social Stress, IMPRESS). We show that IMPRESS significantly increases perceived arousal as well as adrenergic (heart rate, pupil diameter, and blood pressure) and hormonal (cortisol) responses. Amygdala and perigenual anterior cingulate cortex (pACC), two key regions of the emotion and stress regulatory circuitry, are significantly engaged by IMPRESS. We further report associations of amygdala and pACC responses with measures of adrenergic arousal (heart rate, pupil diameter) and social environmental risk factors (adverse childhood experiences, urban living). Our data indicate that IMPRESS induces benchmark psychological and endocrinological responses to social evaluative stress, taps into core neural circuits related to stress processing and mental health risk, and is promising for application in mental illness and in longitudinal study designs.
A multi‐contrast MRI approach to thalamus segmentation
Authors: Corona Veronica , Lellmann Jan , Nestor Peter , Schönlieb Carola‐Bibiane , Acosta‐Cabronero Julio 
Published: January 2020

AbstractThalamic alterations occur in many neurological disorders including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Routine interventions to improve symptom severity in movement disorders, for example, often consist of surgery or deep brain stimulation to diencephalic nuclei. Therefore, accurate delineation of grey matter thalamic subregions is of the upmost clinical importance. MRI is highly appropriate for structural segmentation as it provides different views of the anatomy from a single scanning session. Though with several contrasts potentially available, it is also of increasing importance to develop new image segmentation techniques that can operate multi‐spectrally. We hereby propose a new segmentation method for use with multi‐modality data, which we evaluated for automated segmentation of major thalamic subnuclear groups using T1‐weighted, ‐weighted and quantitative susceptibility mapping (QSM) information. The proposed method consists of four steps: Highly iterative image co‐registration, manual segmentation on the average training‐data template, supervised learning for pattern recognition, and a final convex optimisation step imposing further spatial constraints to refine the solution. This led to solutions in greater agreement with manual segmentation than the standard Morel atlas based approach. Furthermore, we show that the multi‐contrast approach boosts segmentation performances. We then investigated whether prior knowledge using the training‐template contours could further improve convex segmentation accuracy and robustness, which led to highly precise multi‐contrast segmentations in single subjects. This approach can be extended to most 3D imaging data types and any region of interest discernible in single scans or multi‐subject templates.
Memory materials and devices: From concept to application
Authors: Zhang Zhenhan , Wang Zongwei , Shi Tuo , Bi Chong , Rao Feng , Cai Yimao , Liu Qi , Wu Huaqiang , Zhou Peng 
Published: January 2020

AbstractMemory cells have always been an important element of information technology. With emerging technologies like big data and cloud computing, the scale and complexity of data storage has reached an unprecedented peak with a much higher requirement for memory technology. As is well known, better data storage is mostly achieved by miniaturization. However, as the size of the memory device is reduced, a series of problems, such as drain gate‐induced leakage, greatly hinder the performance of memory units. To meet the increasing demands of information technology, novel and high‐performance memory is urgently needed. Fortunately, emerging memory technologies are expected to improve memory performance and drive the information revolution. This review will focus on the progress of several emerging memory technologies, including two‐dimensional material‐based memories, resistance random access memory (RRAM), magnetic random access memory (MRAM), and phase‐change random access memory (PCRAM). Advantages, mechanisms, and applications of these diverse memory technologies will be discussed in this review.image
MicroRNA‐628‐5p inhibits invasion and migration of human pancreatic ductal adenocarcinoma via suppression of the AKT/NF‐kappa B pathway
Authors: Zhou Lin , Jiao Xiaoxiao , Peng Xiaoqian , Yao Xiaomeng , Liu Lu , Zhang Lianfeng 
Published: January 2020

AbstractThe biological function and underlying mechanism of microRNA‐628‐5p (miR‐628‐5p) remains to be clarified in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Here, the expression levels of miR‐628‐5p in PDAC tissues and cells were detected by quantitative reverse transcriptase polymerase chain reaction and in situ hybridization. The relationship between miR‐628‐5p expression and clinicopathologic characteristics was examined in human PDAC tissue samples. Gain‐ and loss‐of‐function and the putative targets of miR‐628‐5p were evaluated in PDAC cell lines. The upstream and downstream signals of miR‐628‐5p in PDAC were also examined. MiR‐628‐5p was lowly expressed in PDAC tissues and cell lines, and low miR‐628‐5p expression in PDAC tissues was associated with poor clinicopathological characteristics and shorter overall survival. Functionally, restoration of miR‐628‐5p expression decreased PDAC cell proliferation, migration, invasion, and promoted cell apoptosis, whereas miR‐628‐5p silencing abolished these biological behaviors. MiR‐628‐5p was found to target and negatively regulate phospholipid scramblase 1 and insulin receptor substrate 1 expression, which resulted in the inhibition of the AKT/NF‐κB signaling pathway. MYC knockdown led to miR‐628‐5p upregulation, whereas MYC overexpression repressed miR‐628‐5p expression. These findings indicate that miR‐628‐5p functions as a tumor‐suppressive microRNA in PDAC and implicate miR‐628‐5p as a potential therapeutic target for PDAC patients.
RETRACTED: Long noncoding RNA ITGB2‐AS1 promotes growth and metastasis through miR‐4319/RAF1 axis in pancreatic ductal adenocarcinoma
Authors: Yang Ming , Qin Qi , Zhu Junling , Guo Yao , Yin Tao , Wu Heshui , Wang Chunyou 
Published: January 2020

AbstractLong noncoding RNA (lncRNA) has been considered as potentially critical regulators in pancreatic ductal adenocarcinoma (PDAC). In this study, we prospectively investigate the effect and mechanism of lncRNA integrin subunit beta 2‐anti‐sense RNA 1 (ITGB2‐AS1) on regulation of PDAC progression. The expression of ITGB2‐AS1 and its target were analyzed by quantitative real‐time polymerase chain reaction and in situ hybridization. 3‐(4,5‐Dimethylthiazol‐z‐yl)‐2,5‐diphenyltetrazolium bromide, flow cytometry, wound healing, and transwell assays were used to investigate the influence of ITGB2‐AS1 on cell proliferation, cell cycle, migration, and invasion, respectively. The interaction between ITGB2‐AS1 and its target was determined via luciferase activity assay and RNA immunoprecipitation. The subcutaneous xenotransplanted tumor model was established and employed to detect the tumorigenic function of ITGB2‐AS1, which was evaluated by western blot analysis, immunohistochemistry, and hematoxylin and eosin staining. The results showed that ITGB2‐AS1 was elevated in both PDAC tumor tissues and cell lines, predicting a poor prognosis in PDAC patients. Knocking down of ITGB2‐AS1 suppressed PDAC cell proliferation, invasion, and migration but induced cell apoptosis in vitro. Moreover, ITGB2‐AS1 could target and inhibit the expression of miR‐4319 and miR‐4319‐targeted and ‐suppressed serine/threonine kinase RAF1. ITGB2‐AS1 promoted PDAC progression via inhibition of miR‐4319. Interference of ITGB2‐AS1 could suppress in vivo tumorigenic ability of PDAC via downregulation of RAF1. In conclusion, ITGB2‐AS1 promoted PDAC progression via sponging miR‐4319 to upregulate RAF1, suggesting the potential therapeutic target ability of ITGB2‐AS1 in PDAC.
MicroRNA‐4731‐5p delivered by AD‐mesenchymal stem cells induces cell cycle arrest and apoptosis in glioblastoma
Authors: Allahverdi Amir , Arefian Ehsan , Soleimani Masoud , Ai Jafar , Nahanmoghaddam Negin , Yousefi‐Ahmadipour Aliakbar , Ebrahimi‐Barough Somayeh 
Published: January 2020

AbstractGlioblastoma multiforme (GBM) exhibits the most malignant brain tumor with very poor prognosis. MicroRNAs (miRNAs) are regulatory factors that can downregulate the expression of multiple genes. Several miRNAs acting as tumor‐suppressor genes have been identified so far. The delivery of miRNA by mesenchymal stem cell (MSC) due to their ability to specifically target tumors is a new, hopeful therapeutic approach for glioblastoma. The objective of our study is the investigation of the effect of lentivirus‐mediated microRNA‐4731 (miR‐4731) genetic manipulated adipose‐derived (AD)‐MSC on GBM. The downregulation of miR‐4731 in human GBM tumor was detected using the GEO dataset. To evaluate the function of miR‐4731, we overexpressed miR‐4731 using lentiviral vectors in U‐87 and U‐251 GBM cell lines. The effects of miR‐4731 on cell proliferation and cell cycle of glioma cells were analyzed by wound test and flow‐cytometry assay. miR‐4731 inhibited the proliferation of GBM cancer cells. Coculturing was used to study the antiproliferative effect of miR‐4731‐AD‐MSCs on GBM cell lines. Direct and indirect coculture of GBM cell lines with miR‐4731‐AD‐MSCs induced cell cycle arrest and apoptosis. Our findings suggest that AD‐MSCs expressing miR‐4731 have favorable antitumor characteristics and should be further explored in future glioma therapy.
Acrylic acid synthesis via condensation of acetic acid and formaldehyde catalyzed by silica aerogel‐supported SiW/PW/PMo oxides
Authors: Shen Lingqin , Yu Zhongyong , Yin Hengbo , Wang Chengtao , Wang Aili , Shao Shouyan 
Published: January 2020

AbstractBACKGROUNDThe demand for acrylic acid continues to increase rapidly due to its widespread application. The traditional production of acrylic acid originates from non‐sustainable propylene oxidation. Considering the environmental requirements and economic sustainable development, it is of great significance to exploit new routes to replace the petrochemical route.RESULTSComparison of silica aerogel‐supported SiW/PW/PMo catalysts shows that PW/SiO2 catalyst with 30 wt% loading and calcined at 450 °C provides the best performance for the condensation of acetic acid and formaldehyde. Increasing the reaction temperature from 340 to 400 °C leads to the best acrylic acid selectivities of 87.1–84.2% at formaldehyde conversions of 35.7–45.2%.CONCLUSIONSThe catalytic performance of PW/SiO2 catalyst increases with increasing PW loading. The acidic and basic sites of the catalyst, especially the weak ones, are of vital importance to the synthesis of acrylic acid via the aldol condensation of acetic acid and formaldehyde. © 2020 Society of Chemical Industry
Valuing water quality benefits from adopting best management practices: A spatial approach
Authors: Choi Dong Soon , Ready Richard C. , Shortle James S. 
Published: January 2020

AbstractWe developed a GIS‐based tool that values, in a spatially explicit way, the ecosystem services generated by water quality improvements resulting from adoption of agricultural best management practices (BMPs). The tool is calibrated for watersheds in the Chesapeake Bay drainage and includes the benefits from water quality improvements within targeted watersheds, water quality improvements downstream from targeted watersheds, and reductions in pollutant loadings to Chesapeake Bay. The tool is used to investigate specific BMP scenarios adopted within specific watersheds. The results show that (i) BMP adoption generates large positive net benefits to society, with benefit/cost ratios ranging from 22 to 276; (ii) by selecting cost effective BMPs and placing them in the most appropriate places, the cost of meeting pollutant reduction targets would be reduced by 34–71%; and (iii) net benefits from BMP adoption are higher when they are implemented close to or upstream from population centers.
Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy
Authors: Mohamad Isa Irma Izani , Abu Bakar Suhaili , Ab Rahman Ahmad Kashfi 
Published: January 2020

AbstractThe impact of sociodemographic and clinical factors on immune recovery and viral load suppression among HIV‐1 positive patients treated with HAART particularly in Malaysia is largely unknown. This cross‐sectional study enrolled 170 HIV‐1‐infected individuals of three major ethnicities who attended three HIV outpatient clinics in Malaysia. Questionnaire was used to obtain sociodemographic data while CD4 count and viral load data were gathered from hospital's record. Multiple factors were assessed for their predictive effects on CD4 count recovery (≥500 cells/mm3) and viral load suppression (≤50 copies/mL) using binary logistic regression. Most of the subjects were male (149/87.6%), in the age group 30 to 39 years old (78/45.9%) and got infected via homosexual contact (82/48.2%). Indians were associated with 11 times higher chance for CD4 recovery as compared to Malays at 8 to 12 months of HAART (adjusted OR: 10.948, 95% CI: 1.873, 64.001, P = .008). Viral load suppression was positively influenced by intravenous drug use (IVDU) status (adjusted OR: 35.224, 95% CI: 1.234, 1000.489, P = .037) at 4 to 6 months of HAART. Higher pretreatment CD4 count was a positive predictor for both initial immunological and virological responses while higher pretreatment viral load was a negative predictor for virological suppression only. In conclusion, ethnicity plays a significant role in determining early immune reconstitution in Malaysia, besides pretreatment CD4 count. Further studies are needed to identify possible biological factors underlying this association.
Capillary electrophoresis with capacitively coupled contactless conductivity detection for the determination of urinary ethylmalonic acid for the diagnosis of ethylmalonic aciduria
Authors: Özçelik Sirun , Öztekin Nevin , Kıykım Ertuğrul , Cansever Mehmet Şerif , Aktuğlu‐Zeybek Ayşe Çiğdem 
Published: January 2020

AbstractEthylmalonic acid is a metabolic organic acid, and its accumulation in urine is diagnostic of ethylmalonic aciduria. In this study, a simple and fast method employing capillary electrophoresis equipped with capacitively coupled contactless conductivity detection was developed for the detection of ethylmalonic acid in urine samples. The optimized electrophoretic separation was performed in 50 mmol/L 2‐(N‐morpholino)ethanesulfonic acid solution, buffered at a pH of 6.5, and contained 0.13 mmol/L cetyltrimethylammonium bromide as an electroosmotic modifier. Electrophoresis was run at 28 kV in reversed polarity. The linear range of ethylmalonic acid concentration was between 1 and 100 mg/L with a regression coefficient of 0.9998. This method had good intra‐ and interday precision with <5% relative standard deviations. The detection limit (signal‐to‐noise ratio = 3) and the quantification limit (signal‐to‐noise ratio = 10) values were 0.139 and 0.466 mg/L, respectively. Using our optimized conditions, the method was successfully employed for the detection of ethylmalonic acid in urine sample of ethylmalonic aciduria patient.
Investigation on Naphthalene and Its Derivatives‐Based Microporous Organic Hyper‐Cross‐Linked Polymers via Different Methodologies
Authors: Teng Dao‐Guang , Wei Xian‐Yong , Yang Zheng , Zhu Qing‐Jiang , Gao Hua‐Shuai , Li Jia‐Hao , Zhang Min , Zong Zhi‐Min 
Published: January 2020

AbstractA series of cost‐effective hyper‐cross‐linked polymers (HCLPs) are synthesized from naphthalene via the external cross‐linker (ECL) knitting method, the solvent knitting method, and the Scholl coupling reaction, respectively. According to multiple characterizations, the resulting polymers are thermally stable and fluorescent with large specific surface areas (SSAs) and narrow pore distributions. In particular the HCLP synthesized using dimethoxymethane as the ECL exhibits SSAs up to 2870 m2 g−1 and shows a great potential in gas adsorption applications. Naphthol and 1‐methylnaphthalene are used as monomers to synthesize HCLPs by the above three methods to investigate whether introducing functional groups to naphthalene would improve properties of the resulting polymers. Moreover, HCLPs feature high SSAs, outstanding thermal and fluorescent performances, and facile synthesis, making them promising candidates for industrial applications.
Closed injective ideals of multilinear operators, related measures and interpolation
Authors: Manzano Antonio , Rueda Pilar , Sánchez‐Pérez Enrique A. 
Published: January 2020

AbstractWe introduce and discuss several ways of extending the inner measure arisen from the closed injective hull of an ideal of linear operators to the multilinear case. In particular, we consider new measures that allow to characterize the operators that belong to a closed injective ideal of multilinear operators as those having measure equal to zero. Some interpolation formulas for these measures, and consequently interpolation results involving ideals of multilinear operators, are established. Examples and applications related to summing multilinear operators are also shown.
Grafting PMMA onto P(VDF‐TrFE) by CF Activation via a Cu(0) Mediated Controlled Radical Polymerization Process
Authors: Liao Jiani , Peng Biyun , Tan Shaobo , Tian Xin , Zhang Zhicheng 
Published: January 2020

AbstractIn the present work, poly(methyl methacrylate) (PMMA) is successfully grafted onto poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)) side chains via directly activated CF bonds using Cu(0)/2,2′‐bipyridine as catalyst. The reaction mechanism and the initiating sites can be confirmed by the structure of the graft copolymer. The graft copolymerization exhibits first‐order kinetics, and reaction conditions can affect the chemical composition of the graft copolymer, including reaction time, reaction temperature, solvents, the amount of catalyst, and monomer. The introduction of rigid PMMA side chains onto P(VDF‐TrFE) can effectively tune the displacement–electric field hysteresis behaviors of P(VDF‐TrFE) from normal ferroelectric to anti‐ferroelectric, even linear‐like dielectric, under high electric field, resulting in dramatically reduced energy loss while maintaining the discharged energy density. This work may provide an effective strategy to introduce functional groups into P(VDF‐TrFE) copolymer via activation of CF bonds.
Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score
Authors: Iwaki Hirotaka , Blauwendraat Cornelis , Makarious Mary B. , Bandrés‐Ciga Sara , Leonard Hampton L. , Gibbs J. Raphael , Hernandez Dena G. , Scholz Sonja W. , Faghri Faraz ,   International Parkinson's Disease Genomics Consortium (IPDGC), Nalls Mike A. , Singleton Andrew B. 
Published: January 2020

AbstractBackgroundAlthough the leucine‐rich repeat kinase 2 p.G2019S mutation has been demonstrated to be a strong risk factor for PD, factors that contribute to penetrance among carriers, other than aging, have not been well identified.ObjectivesTo evaluate whether a cumulative genetic risk identified in the recent genome‐wide study is associated with penetrance of PD among p.G2019S mutation carriers.MethodsWe included p.G2019S heterozygote carriers with European ancestry in three genetic cohorts in which the mutation carriers with and without PD were selectively recruited. We also included the carriers from two data sets: one from a case‐control setting without selection of mutation carriers and the other from a population sampling. Associations between polygenic risk score constructed from 89 variants reported recently and PD were tested and meta‐analyzed. We also explored the interaction of age and PRS.ResultsAfter excluding eight homozygotes, 833 p.G2019S heterozygote carriers (439 PD and 394 unaffected) were analyzed. Polygenic risk score was associated with a higher penetrance of PD (odds ratio: 1.34; 95% confidence interval: [1.09, 1.64] per +1 standard deviation; P = 0.005). In addition, associations with polygenic risk score and penetrance were stronger in the younger participants (main effect: odds ratio 1.28 [1.04, 1.58] per +1 standard deviation; P = 0.022; interaction effect: odds ratio 0.78 [0.64, 0.94] per +1 standard deviation and + 10 years of age; P = 0.008).ConclusionsOur results suggest that there is a genetic contribution for penetrance of PD among p.G2019S carriers. These results have important etiological consequences and potential impact on the selection of subjects for clinical trials. © 2020 International Parkinson and Movement Disorder Society
A novel antimicrobial electrochemical glucose biosensor based on silver–Prussian blue‐modified TiO2 nanotube arrays
Authors: Farajpour Nasim , Deivanayagam Ram , Phakatkar Abhijit , Narayanan Surya , Shahbazian‐Yassar Reza , Shokuhfar Tolou 
Published: January 2020

AbstractGlucose biosensors play an important role in the diagnosis and continued monitoring of the disease, diabetes mellitus. This report proposes the development of a novel enzymatic electrochemical glucose biosensor based on TiO2 nanotubes modified by AgO and Prussian blue (PB) nanoparticles (NPs), which has an additional advantage of possessing antimicrobial properties for implantable biosensor applications. In this study, we developed two high‐performance glucose biosensors based on the immobilization of glucose oxidase (GOx) onto Prussian blue (PB)‐modified TiO2 nanotube arrays functionalized by Au and AgO NPs. AgO‐deposited TiO2 nanotubes were synthesized through an electrochemical anodization process followed by Ag electroplating process in the same electrolyte. Deposition of PB particles was performed from an acidic ferricyanide solution. The surface morphology and elemental composition of the two fabricated biosensors were investigated by scanning electron microscopy (SEM) and energy‐dispersive X‐ray spectroscopy (EDS) which indicate the successful deposition of Au and AgO nanoparticles as well as PB nanocrystals. Cyclic voltammetry and chronoamperometry were used to investigate the performance of the modified electrochemical biosensors. The results show that the developed electrochemical biosensors display excellent properties in terms of electron transmission, low detection limit and high stability for the determination of glucose. Under the optimized conditions, the amperometric response shows a linear dependence on the glucose concentration to a detection limit down to 4.91 µM with sensitivity of 185.1 mA M−1 cm−2 in Au‐modified biosensor and detection limit of 58.7 µM with 29.1 mA M−1 cm−2 sensitivity in AgO‐modified biosensor.