bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wie viel Geschichte steckt in sprachlichen Bedeutungen?
Authors: Reuter Gerson 
Published: December 2019

AbstractCertainly, we sometimes use language creatively and think really new thoughts. However, can we think and speak regardless of the manner in which we have spoken and thought in the past? This seems to be highly improbable. Consequently, nobody would assert something like this. But that being a given, what are the exact reasons that prevent us from radically detaching ourselves from our past practices of thinking and speaking? What roles do past facts play in determining what we are able to think and speak today? This essay looks at the motivation for examining and determining the impact of ‘our history’ on semantics. If possible, these ideas should appeal independently of special or contentious theoretical presuppositions.
Epistemologie der Medialität
Authors: Krämer Sybille 
Published: December 2019

Abstract
The logic of media usage is determined by the self-blinding of the materiality of the medium in the act of its transmitting function. According to the traditional topos of the ‘dying messenger’, a messenger-oriented model of mediality is developed. Contrary to the appearance of the ‘vanishing’ medium, a critical media philosophy has to depict that and how media always shape and constitute what they represent. One phenomenon mostly being invisible in our normal use of texts and pictures is the medium of ‘artificial flatness’ within the framework of a ‘cultural technique of flattening’: scientific, technical and artistic creativity is inconceivable without two-dimensional inscriptions in the form of writings, graphs, diagrams and maps. But how can this imprinting power of inscribed and illustrated surfaces be grasped if at the same time the role of media is understood in terms of transmission, connection, intermediation? Our suggestion is to describe the shaping power of media by the concept of ‘transfiguration’: From a transfigurative perspective, the medium only reveals itself as a trace on its content. Traces are visible transformations in the mode of latency. To manifest this latency, to make the implicit explicit, is then a task of media philosophy. As examples of such a critical-epistemological reflection, the relationship between writing and language, as well as between map and territory, is discussed.
Use of simulation model for measurement of MilkRun system performance
Authors: Fedorko Gabriel , Vasil Martin , Bartosova Michaela 
Published: December 2019

AbstractIntra-plant transport systems within their operation directly impact on the performance of production systems. For their effective operation, it is, therefore, necessary to realize evaluation of operational performance and effectivity. For the realization of this type of evaluation, in addition to a wide range of sensors that can be difficult for installation and operation, we can also use indirect methods that are equally able to provide reliable operational characteristics. Indirect analytical methods are presented above all by the approach which is based on the use of simulation methods. The method of computer simulation provides a wide range of options for the evaluation of efficiency and performance. The paper describes the use of a simulation model created in the program Tecnomatix Plant Simulation for analyzing the supply of production workplaces within the MilkRun system.
Design of clamping structure for material flow monitor of pipe conveyors
Authors: Molnár Vieroslav , Lipovcová Katarína 
Published: December 2019

Abstract
In terms of monitoring the material and volume flow of pipe conveyors, the conveyor is considered to be a volumetric machine that does not have a "self-defence" function - in most cases, material needs to be dosed and monitored in the critical parts of the conveyor for smooth transportation and quick detection of deficiencies and errors. Appropriate attachment of the material flow sensor to the pipe conveyor structure plays an important role for efficient material monitoring on the pipe conveyor belt. The paper specifies and subsequently analyzes selected methods of mounting an optical material flow monitor - the Bulkscan LMS511, based on the ratio index method by analyzing the advantages and disadvantages of individual variants. The optimal variant is modelled in the PTC Creo Parametric program and the estimated costs for its implementation are evaluated.
Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
Authors: Šipula David , Kozák Milan , Šipula Jaroslav , Homza Miroslav , Plášek Jiří 
Published: December 2019

Abstract

Background
Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy – Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients.

Methods
30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed.

Results
A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology.

Conclusions
AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.
A FacileIn-SituDevelopment of L-Valine Film onto the Surface of Carbon Paste Electrode Towards the Detection of Environmentally Hazardous 4-Amino Phenol
Authors: Gopal T. Venu , Reddy Tukiakula Madhusudana , Shaikshavali P. , Venkataprasad G. , Gopal P. 
Published: December 2019

AbstractA small scale of environmentally hazardous 4-aminophenol can show significant impact on human health. Hence, in the present work, we have designed L-Valine film (Vf) modified carbon paste electrode (Vf/CPE) for the determination of 4-aminophenol. Herein, a facilein-situL-Valine film was developed by electrochemical polymerization method onto the surface of bare carbon paste electrode (BCPE) with the help of cyclic voltammetry (CV) technique. A two-folds of electrochemical peak current enhancement was achieved at Vf/CPE in comparison with BCPE towards the determination of 4-aminophenol in optimum pH 7.0 of phosphate buffer solution (PBS). This was achieved due to the large surface area and conductive nature of Vf/CPE, which was concluded through the techniques of cyclic voltammetry and electrochemical impedance spectroscopy (EIS). The effect of pH of buffer and scan rate studies were successfully studied. Morphological changes of BCPE and Vf/CPE was studied with the help of scanning electron microscopy (SEM). The formation of Vf on CPE was also analyzed by Fourier transform infrared (FTIR) spectra. Under the optimized conditions, the limit of detection (LOD) and limit of quantification (LOQ) values of 4-aminophenol were estimated with the aid of chronoamperometry (CA) technique and was found to be 9.8 μM and 32 μM, respectively. Finally the proposed method was found to have satisfactory repeatability, reproducibility and stability results with low relative standard deviation (RSD) values.
Sorption Studies of Chromate by Iron Oxide from Drinking Water
Authors: Sultana Qamar , Naeem A. , Mahmood Tahira , Ud Din Israf , Saeed Tooba , Khan Nadir , Ahmad Tauqeer 
Published: December 2019

Abstract
Chromium is well-thought-out heavy metal which is one of the enormously lethal due to its cancer-causing nature. In this study, iron oxide is used as adsorbent for chromate removal from aqueous solution as a function of pH, time, temperature, concentration of adsorbate and media dosage. The influence of pH on Cr (VI) sorption by iron oxide reveals that adsorption is significantly increased as pH is decreased from 8 to 2. The sorption rate is detected to be higher in the beginning and then it remains constant after 120 min of equilibrium time. The removal of Cr (VI) is found to be greater at higher temperature, which confirms the endothermic nature of Cr (VI) adsorption by iron oxide. Whereas, the kinetic investigations confirm that the chromate adsorption follows the pseudo second order with kinetic energy in the range of 8.4–83.7 kJ mol−1.
Tissue-Specific DNA Replication Defects inDrosophila melanogasterCaused by a Meier-Gorlin Syndrome Mutation in Orc4
Authors: McDaniel Stephen L , Hollatz Allison J , Branstad Anna M , Gaskill Marissa M , Fox Catherine A , Harrison Melissa M 
Published: December 2019

AbstractMeier-Gorlin syndrome (MGS) is a recessive disorder caused by mutations in genes associated with DNA replication. Despite the fact these proteins are essential for replication in every cell, patients with MGS have tissue-specific defects...Meier-Gorlin syndrome is a rare recessive disorder characterized by a number of distinct tissue-specific developmental defects. Genes encoding members of the origin recognition complex (ORC) and additional proteins essential for DNA replication (CDC6, CDT1, GMNN, CDC45, MCM5, and DONSON) are mutated in individuals diagnosed with MGS. The essential role of ORC is to license origins during the G1 phase of the cell cycle, but ORC has also been implicated in several nonreplicative functions. Because of its essential role in DNA replication, ORC is required for every cell division during development. Thus, it is unclear how the Meier-Gorlin syndrome mutations in genes encoding ORC lead to the tissue-specific defects associated with the disease. To begin to address these issues, we used Cas9-mediated genome engineering to generate a Drosophila melanogaster model of individuals carrying a specific Meier-Gorlin syndrome mutation in ORC4 along with control strains. Together these strains provide the first metazoan model for an MGS mutation in which the mutation was engineered at the endogenous locus along with precisely defined control strains. Flies homozygous for the engineered MGS allele reach adulthood, but with several tissue-specific defects. Genetic analysis revealed that this Orc4 allele was a hypomorph. Mutant females were sterile, and phenotypic analyses suggested that defects in DNA replication was an underlying cause. By leveraging the well-studied Drosophila system, we provide evidence that a disease-causing mutation in Orc4 disrupts DNA replication, and we propose that in individuals with MGS defects arise preferentially in tissues with a high-replication demand.
Identidades estudiantiles y retos pedagógicos
Authors: Camacho Oviedo Maureen , Castillo Cedeño Rocío , León Arce Heidy , Miranda Calderón Alfredo , Pereira Pérez Zulay , Vásquez Salazar Erika 
Published: December 2019

Recibido 26 de setiembre de 2012 • Corregido 04 de febrero de 2013 • Aceptado 13 de marzo de 2013El presente artículo, surge del proceso de inducción de estudiantes de primer ingreso, en el 2012, a cuatro carreras de Pedagogía en la División de Educación Básica del Centro de Investigación y Docencia en Educación (CIDE) en la Universidad Nacional. Recoge la información de 110 estudiantes. Busca la identificación de rasgos que permitan la conformación de identidades estudiantiles y los posibles retos pedagógicos que de ello se deriven. Retoma las acciones llevadas a cabo para el diseño y ejecución del proceso de inducción y los datos que aportan los instrumentos utilizados. Los hallazgos acerca de las identidades estudiantiles plantean áreas fuertes y áreas por desarrollar, que, en este caso particular, se convierten en los retos pedagógicos que han de ser atendidos desde la unidad académica. La División de Educación Básica, formadora de profesionales en diferentes disciplinas, tiene una gran responsabilidad en la transformación social y cultural del país, preparando profesionales en educación y brindando las herramientas necesarias para que los estudiantes y las estudiantes puedan lograr mayores habilidades artísticas, habilidades en redacción y ortografía, habilidades tecnológicas, habilidades deportivas, habilidades para hablar en público: estos son algunos de los retos que emergen del análisis del proceso de inducción realizado con estudiantes de nuevo ingreso.
La actitud hacia la docencia, la formación integral en la educación secundaria y a su proyecto de vida: Una visión desde los estudiantes de colegios en áreas rurales
Authors: Quirós Meneses Elionay , Jiménez Sánchez Xiomara 
Published: December 2019

Recibido 18 de junio de 2012 • Corregido 05 de marzo de 2013 • Aceptado 13 de marzo de 2013
Estudio transcenccional descriptivo de enfoque cuantitativo acerca de la actitud hacia la docencia, la formación integral en la educación secundaria y a su proyecto de vida: una visión desde los estudiantes de colegios en áreas rurales, el cual fue realizado en el año 2011. Participaron 41 estudiantes de undécimo año de colegios rurales costarricenses que forman parte del programa Esperanza joven, de la División de Educología de la Universidad Nacional. La información se recopiló con una escala Likert, cuyos resultados permitieron destacar, en los estudiantes, una actitud positiva hacia el desempeño docente, la formación integral, evaluación de los aprendizajes, incentivos familiares e institucionales y metas personales. En tanto, la incentivación que ofrece la institución hacia los estudiantes obtuvo una actitud negativa. Lo anterior permite hacer un análisis objetivo y llegar a conclusiones precisas.
La mediación biopedagógica desde una perspectiva ética
Authors: Castillo Cedeño Ileana , Castillo Cedeño Rocío 
Published: December 2019

Recibido 28 de febrero de 2013 • Corregido 10 de marzo de 2013 • Aceptado 13 de marzo de 2013
Este ensayo aborda el tema de la mediación biopedagógica desde una perspectiva ética, considera la trascendencia que tiene el situar a la educación desde un paradigma alternativo, donde pedagogía y vida se complementan para atender el sentido emancipador del proceso educativo.El objetivo es aportar a la reflexión y la acción sobre la mediación pedagógica y su inherente concatenación con la ética. Se parte de la premisa de la necesidad de cultivar el sentido de la existencia, desde principios y valores que exalten la vida en su multidimensionalidad y complejidad.La educación como proyecto político debe responder al reto de preparar para una ciudadanía planetaria, esfuerzo compartido que compromete a todo ser humano a trabajar por una verdadera transformación social y, por tanto, mental, para obtener mejores estados de bienestar personal y social. Se requiere direccionar todas las energías y sabiduría para poder visualizar la transformación humana que tanto demanda el planeta.
Las instituciones de educación superior y la responsabilidad social en el marco de la sustentabilidad
Authors: Cantú-Martínez Pedro César 
Published: December 2019

Recibido 28 de enero de 2013 • Corregido 10 de junio de 2013 • Aceptado 19 de junio de 2013El presente artículo de revisión aborda un tema de trascendental importancia para las instituciones de educación superior, como es la responsabilidad social. El enfoque de responsabilidad social retoma un apogeo en el dominio de los debates por la crisis ambiental y por la búsqueda del desarrollo sustentable. Este artículo de revisión expone, en particular, cómo en México, las instituciones de educación superior deben contar con un desarrollo, tanto cualitativo como cuantitativo, muy relevante que trascienda y sea permanente para contextualizar las demandas de nuestra sociedad. Además, se menciona la experiencia de implementación de la responsabilidad social en la Universidad Autónoma de Nuevo León.
Actividades de aprendizaje y TIC: Usos entre docentes de la Educación General Básica costarricense. Aproximación diagnóstica
Authors: Campos Jiménez Karolina , Carvajal Jiménez Vivian , Castro Gutiérrez Enia Romilia , Hutchinson Heath Sandra , Masís Muñoz Maribel , Murillo León Susana , Rojas Alvarado Grace , Rojas Ramírez Fabián , Sánchez Chacón Giovanny 
Published: December 2019

Recibido 11 de octubre de 2013 • Corregido 22 de noviembre de 2013 • Aceptado 06 de diciembre de 2013Dos de las entidades encargadas de administrar y decidir acerca de la formación inicial y continua de los docentes costarricenses, a saber, el Ministerio de Educación Pública (MEP) y la Universidad Nacional (UNA), desarrollaron entre 2011 y 2012 un proceso investigativo para apoyar la construcción de conocimientos relacionados con la incorporación de las tecnologías de la información y la comunicación (TIC) en contextos educativos y, al mismo tiempo, participar de la generación de innovaciones que coadyuven a fundamentar y orientar las políticas educativas nacionales y de formación docente. Dicha indagación parte del reconocimiento de actividades de aprendizaje que se apoyan en las TIC y que son implementadas por el personal docente, en la Educación General Básica (EGB), como una forma de orientar su quehacer educativo hacia espacios críticos, colaborativos y gestores de aprendizajes relevantes para los involucrados. Para esta exploración, se consideran catorce de las regiones educativas en las que el MEP divide el país: Desamparados, Limón, San Ramón, Los Santos, Pérez Zeledón, Grande de Térraba, Puntarenas, Aguirre, Coto, Liberia, Upala, Cañas, Santa Cruz y Nicoya. Para el abordaje teórico, esta propuesta se basa en los aportes de César Coll (2005), quien parte de las relaciones existentes en lo que este autor llama el triángulo interactivo; una metodología que remite al estudio de relaciones entre tres elementos: el contenido, la actividad educativa instruccional del profesorado y las actividades de aprendizaje del grupo estudiantil. En este artículo se abordan nueve de las categorías que Coll (2005) señala como frecuentes en las prácticas de mediación que involucran las TIC y, adicionalmente, emergen tres categorías que la investigación arroja para comprender en qué situaciones y con qué fines los docentes costarricenses de la EGB emplean las TIC durante su práctica pedagógica. Este trabajo es desarrollado por un equipo interinstitucional de investigadores de la Universidad Nacional y el Ministerio de Educación Pública.
La formación integral del estudiantado de ingeniería a través de la educación continua
Authors: Reynoso Flores Miguel , Castillo Elizondo Jaime Arturo , Dimas Rangel María Isabel 
Published: December 2019

Recibido 4 de octubre de 2013 • Corregido 29 de octubre de 2013 • Aceptado 6 de noviembre de 2013El presente artículo aborda un tema prioritario para la formación del estudiantado en general y en particular para los futuros ingenieros e ingenieras. A pesar de que en los últimos años se ha abordado con frecuencia esta temática; aún son insuficientes las propuestas en el caso del estudiante de ingeniería. El objetivo de este artículo es fundamentar teórica y empíricamente las potencialidades que posee la educación continua como una de las áreas fundamentales que poseen las facultades de ingeniería para la formación integral de sus estudiantes. Se muestran resultados preliminares de un proyecto de investigación solicitado por la Facultad de Ingeniería Mecánica y Eléctrica (FIME) de la Universidad Autónoma de Nuevo León, México, a partir de la necesidad de perfeccionar el proceso formativo de los estudiantes con un enfoque integral. Se expone la justificación del estudio y se presentan algunos de los resultados obtenidos en la fase exploratoria.
Characterization of Patients with Biopsy-Proven Non-Alcoholic Fatty Liver Disease and Normal Aminotransferase Levels
Authors: Ulasoglu Celal , Enc Feruze Yilmaz , Kaya Eda , Yilmaz Yusuf 
Published: December 2019

Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of abnormal liver function tests in hepatology practice. However, not all patients with NAFLD have increased aminotransferase levels. The aim of this study was to compare the clinical and histologic characteristics of patients with biopsyproven NAFLD showing normal versus elevated aminotransferase levels.
Methods: We retrospectively reviewed 515 patients with biopsy-proven NAFLD. Patients with ALT ≤ 40 U/L and AST ≤ 37 U/L were considered as having normal liver enzymes. A histological fibrosis score F ≥ 3 was used to define advanced fibrosis.
Results: Of the 515 study participants, 107 (20.8%) had normal liver enzymes. Compared with patients showing elevated liver enzymes, those with normal aminotransferase levels were older and most commonly women. Moreover, they had a higher body mass index and more frequently showed metabolic risk factors (metabolic syndrome, diabetes mellitus, hypertension, higher waist and hip circumferences). Although liver histology tended to be less severe in patients with normal liver enzymes, the prevalence of advanced fibrosis was similar in the two groups. Diabetes mellitus (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.46−3.91, p < 0.001) and age (OR = 1.14, 95% CI = 1.07−1.24, p < 0.05) were identified as independent predictors of advanced fibrosis in patients with normal aminotransferase levels.
Conclusions: NAFLD with normal aminotransferase levels is characterized by a severe metabolic profile and a prevalence of advanced fibrosis similar to that identified in cases with elevated aminotransferase levels.
PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes
Authors: Karamfilova Vera , Gateva Antoaneta , Assyov Yavor , Alexiev Asen , Savov Alexey , Yaneva Nadejda , Ivanova Irena , Ivanova-Boyanova Radina , Ivanova Raya , Vlahova Zlatina , Mateva Ludmila , Kamenov Zdravko 
Published: December 2019

Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance, and therefore predisposes to type 2 diabetes and cardiovascular diseases. Lipid deposition in the liver seems to be critical in the pathogenesis of NAFLD. A common genetic variant, the patatin-like phospholipase domain-containing protein 3 (PNPLA3) has been associated with NAFLD. The aim of the present study was to evaluate the association between PNPLA3, key gene of lipid metabolism and the metabolic traits in obesity NAFLD patients with and without prediabetes.
Methods: A total of 208 obese NAFLD patients without (n=125) and with prediabetes (n=83) were included. The genotyping of PNPLA3 I148M variant (rs738409) was performed by restriction analysis.
Results: Regarding rs738409 (I148M) polymorphism, CG genotype was positively correlated with prediabetes, insulin resistance, dyslipidemia and metabolic syndrome compared to the wild CC genotype. The carriers of the PNPLA3 I148M variant have 9.6-fold higher risk of glucose disturbances compared to wild genotype (OR 9.649, 95%CI 2.100-44.328, р=0.004). The carriers of the PNPLA3 I148M variant also have a 3 times higher risk for the presence of metabolic syndrome (OR 2.939, 95% CI: 1.590-5.434, p=0.001) and a 2.1-fold higher risk for the presence of insulin resistance (OR 2.127, 95% CI: 1.078-4.194, p=0.029).
Conclusions: PNPLA3 I148M is associated with increased risk of prediabetes, metabolic syndrome and insulin resistance in obese patients with NAFLD.