bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute symptomatic extracranial internal carotid occlusion –	natural course and clinical impact
Authors: Hause Stephan , Oldag Andreas , Breja Andrea , Neumann Jens , Wilcke Juliane , Schreiber Stefanie , Heinze Hans-Jochen , Skalej Martin , Halloul Zuhir , Goertler Michael 
Published: October 2019

Summary: Background: To assess the vascular and clinical course of acute symptomatic extracranial internal carotid artery (ICA) occlusion. Patients and methods: Patients with an acute ischemic event in the anterior circulation and corresponding extracranial ICA occlusion at CT angiography and/or color-coded duplex sonography underwent recurrent duplex follow-up for detection of spontaneous recanalization. Stroke recurrence and functional outcome 4.5 months after the ischemic index event assessed by modified Rankin scale served as secondary outcome parameters. Results: 133 patients (91 men, mean age 62.3 years, SD 10.8) demonstrated symptomatic occlusion of the extracranial ICA with open intracranial ICA and open middle cerebral artery and were followed-up for spontaneous recanalization. Twenty-eight recanalized spontaneously, 25 to high-grade focal stenosis within 12 days, revealing an early cumulative recanalization rate of 23 %. Detection of recanalization was independently associated with de novo dual anti-platelet therapy (adjusted odds ratio [OR], 3.24; 95 % confidence interval [CI], 1.34 to 7.80). Ischemic recurrence occurred in 16 patients, of which 10 deemed to be embolic and 5 hemodynamic. Spontaneous ICA recanalization and an exhausted cerebrovascular reserve in the hemisphere distal to the occluded ICA were both independently associated with the occurrence of a recurrent ischemic event at Cox regression. An increasing NIHSS score at admission, a decreasing middle cerebral artery flow velocity and an ischemic recurrence independently predicted poor outcome (modified Rankin scale 3 to 6) in multivariate analysis. Conclusions: Acute symptomatic extracranial ICA occlusion is an unstable condition with frequent spontaneous recanalization to severe stenosis and early embolic stroke recurrence, demanding appropriate prevention especially in those patients with only mild deficit.
Signatures of Magnetic Separatrices at the Borders of a Crater Flux Transfer Event Connected to an Active X‐Line
Authors: Trenchi L. , Coxon J. C. , Fear R. C. , Eastwood J. P. , Dunlop M. W. , Trattner K. J. , Gershman D. J. , Graham D. B. , Khotyaintsev Yu. , Lavraud B. 
Published: October 2019

AbstractIn this paper, we present Magnetospheric Multiscale (MMS) observations of a flux transfer event (FTE) characterized by a clear signature in the magnetic field magnitude, which shows maximum at the center flanked by two depressions, detected during a period of stable southward interplanetary magnetic field. This class of FTEs are called “crater‐FTEs” and have been suggested to be connected with active reconnection X line. The MMS burst mode data allow the identification of intense fluctuations in the components of the electric field and electron velocity parallel to the magnetic field at the borders of the FTE, which are interpreted as signatures of the magnetic separatrices. In particular, the strong and persistent fluctuations of the parallel electron velocity at the borders of this crater‐FTE reported for the first time in this paper, sustain the field‐aligned current part of the Hall current system along the separatrix layer, and confirm that this FTE is connected with an active reconnection X line. Our observations suggest a stratification of particles inside the reconnection layer, where electrons are flowing toward the X line along the separatrix, are flowing away from the X line along the reconnected field lines adjacent to the separatrices, and more internally ions and electrons are flowing away from the X line with comparable velocities, forming the reconnection jets. This stratification of the reconnection layer forming the FTE, together with the reconnection jet at the trailing edge of the FTE, suggests clearly that this FTE is formed by the single X line generation mechanism.
Mechanics of Inflationary Deformation During Caldera Collapse: Evidence From the 2018 Kīlauea Eruption
Authors: Segall Paul , Anderson Kyle R. , Johanson Ingrid , Miklius Asta 
Published: October 2019

AbstractDuring the 2018 Kīlauea eruption the caldera floor dropped 500 m in 62 nearly periodic events of up to 8 m. Caldera collapse maintains pressure in the magma reservoir necessary to sustain high‐rate eruptions. The 2018 collapses were accompanied by inflationary tilts and displacements, similar to observations at other basaltic calderas. Collapse is modeled in 2‐D by uniform slip dislocations intersecting a magma chamber. Collapses occurred rapidly, such that mass within the chamber was constant. For vertical faults surface deformation outside the collapse results only from chamber pressurization with displacements antiparallel to precollapse deflation, similar to observations. For inward dipping faults the predicted ratio of horizontal to vertical displacements during collapse is greater than for the precollapse deflation, as observed. For outward dipping faults the horizontal displacements are inward, contrary to data. The average deformation trends during the eruption depend on fault dip and whether stress required to trigger collapses was constant or changed with time.
Propagation of EMIC Waves Inside the Plasmasphere: A Two‐Event Study
Authors: Wang G. , Zhang T. L. , Gao Z. L. , Wu M. Y. , Wang G. Q. , Schmid D. 
Published: October 2019

AbstractElectromagnetic ion cyclotron (EMIC) waves are important for the loss of high‐energy electrons in the radiation belt. Based on the measurements of Van Allen Probes, two events during the same storm period are presented to study the propagation of EMIC waves. In the first event, left‐handed polarized EMIC waves were observed near the plasmapause, while right‐handed waves were observed in the inner plasmasphere. The Poynting flux of the right‐hand waves was mainly directed inward and equatorward, and no positive growth rates were obtained in the region of these right‐hand waves, indicating the inward propagation of the waves from a higher L‐shell. In the second event, the wave vectors were quasi‐perpendicular to the background magnetic field inside the plasmaspheric plume but became quasi‐parallel outside. This phenomenon can be explained by the refraction of the large density gradient, which qualitatively satisfies Snell's law. These observations provide indirect evidence of the inward propagation of the EMIC waves and give a new insight on how density gradients may modify wave properties.
Features of Nightside ULF Wave Activity in the Ionosphere
Authors: Ouyang X.Y. , Bortnik J. , Ren J. , Berthelier J.J. 
Published: October 2019

AbstractWe investigate the features of nightside ultralow frequency (ULF) waves in the ionosphere using electric field data in the DC/ULF range observed by the Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions (DEMETER) satellite over a ~5.5‐year period from May 2005 to November 2010. The ULF wave events are recognized by an automatic detection algorithm, and a superposed epoch analysis is performed to study the characteristics of ULF waves during geomagnetic storms. The results show that (1) ULF waves of both nonmagnetospheric and magnetospheric origins occur in the ionosphere; (2) nonmagnetospheric ULF waves present seasonal variations but have no clear response to storms; (3) magnetospheric ULF waves show clear association with the recovery phase of storms but have no obvious seasonal variations; and (4) an interhemispheric asymmetry with higher magnetospheric ULF wave occurrence rate in the Southern Hemisphere particularly around storms can be partly explained by the fact that more of selected isolated storms occurred during summer in the Northern Hemisphere (NH), hence higher conductivity in the NH. However, an analysis of few storms during equinoxes also shows a minor asymmetry. These results still indicate that the ionospheric conductivity in the Southern Hemisphere would be lower than in the NH at nighttime.
Characterization of the Water Masses in the Shelf Region of the Bering and Chukchi Seas With Fluorescent Organic Matter
Authors: Yamashita Youhei , Yagi Yuki , Ueno Hiromichi , Ooki Atsushi , Hirawake Toru 
Published: October 2019

AbstractPacific water is an important nutrient source for sustaining biological production in the Chukchi Sea, western Arctic Ocean, which is one of the productive regions in the world. Therefore, to understand the impacts of future environmental changes on biological production in the sea, it is crucial to understand the origins, modification processes, and spatiotemporal variations of the water masses from the Bering Sea with changes in nutrient concentrations. To improve water mass analysis in the shelf regions of the Bering and Chukchi Seas, we observed levels of humic‐like fluorescent organic matter (FOMH) by using an in situ fluorometer directly connected to a temperature‐salinity sensor during a cruise in the early summer of 2013 and evaluated the potential of FOMH as a third parameter of water mass analysis. The levels of FOMH were different among specific water masses in the region, and FOMH seemed to behave semiconservatively in the shelf regions of the Bering and Chukchi Seas during the early summer of 2013. The distributional pattern of FOMH implies that FOMH estimated by the in situ fluorometer has the potential to (1) separate warm water into riverine‐affected Alaskan Coastal Water and historically photobleached summer Bering Basin Water; (2) distinguish the Anadyr Water, which has low FOMH levels and high nutrient concentrations, from the Bering Shelf Water; and (3) determine different formation/modification processes of dense shelf water that contains high nutrient concentrations.
Intensified Deep Ocean Variability Induced by Topographic Rossby Waves at the Pacific Yap‐Mariana Junction
Authors: Ma Qiang , Wang Fan , Wang Jianing , Lyu Yilong 
Published: October 2019

AbstractIn a deep channel at the Pacific Yap‐Mariana Junction, intensified variability of flow and isotherm displacements over 3,000–4,600 m is revealed by two separate observations: the recent one during 2014–2016 and the two 20 years ago during 1996–1998. Observed velocity and isotherm displacements can reach 45 cm s−1 and ~600 m at 4,200 m, respectively. Such intensified variability is demonstrated to arise from topographic Rossby waves (TRWs) since vertical profiles of observed currents reasonably conform to TRW features of hyperbolic intensification with depth and highly vertical coherence in phase. Mercator Ocean model outputs reproduce observed TRWs and are used to discuss their energy sources. Both the energetic surface eddy moving across rough topography and mixed barotropic‐baroclinic instability of the background flow appear to be the candidates to generate TRWs.
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4)
Authors: Li Zhengzhao , Lu Junyu , Zeng Guang , Pang Jielong , Zheng Xiaowen , Feng Jihua , Zhang Jianfeng 
Published: October 2019

AbstractThis study was designed to investigate the mechanism by which miR-129-5p affects the biological function of liver cancer cells. The expression levels of miR-129–5p in liver cancer tissues and cells were, respectively, determined. Crystal violet staining and flow cytometry were used to detect cell proliferation and apoptosis. Wound healing assay and transwell assay were performed to test cell migration and invasion. The target gene of miR-129–5p was analyzed and verified by bioinformatics analysis and luciferase reporter assay. Tumorigenicity assays in nude mice were used to test the antitumor ability of calcium calmodulin-dependent protein kinase IV (CAMK4). miR-129–5p was found to be underexpressed in hepatocellular cancer tissues and cells and also to inhibit liver cells proliferation, migration, and invasion and promote apoptosis. CAMK4 was a direct target for miR-129–5p and was lowly expressed in liver cancer tissues and cells. CAMK4 was also found to inhibit liver cells proliferation, migration and invasion, and promote apoptosis. CAMK4 might exert an antitumor effect by inhibiting the activation of mitogen-activated protein kinase (MAPK). MiR-129–5p was a tumor suppressor with low expression in liver cancer tissues and cells. CAMK4, which is a direct target gene of miR-129–5p, could inhibit tumor by inhibiting the activation of MAPK signaling pathway.
SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
Authors: Tan Peng , Xu Yunke , Du Yichao , Wu Lile , Guo Bing , Huang Shiyao , Zhu Jinhui , Li Bo , Lin Fujun , Yao Lei 
Published: October 2019

AbstractSpeckle-type POZ domain protein (SPOP), an adaptor in the E3 ubiquitin ligase complex, recognizes substrates and promotes protein degradation via the ubiquitin-proteasome system. It appears to help regulate progression of several cancers, and we show here that it acts as a tumor suppressor in pancreatic cancer. Our analysis of patient tissues showed decreased SPOP expression, which was associated with poor prognosis. SPOP knockdown in SW1990 (in vitro/vivo) and PANC-1 (in vitro) cells led to significantly greater proliferation, migration, and invasion. Co-immunoprecipitation experiments in SW1990 cells showed that SPOP interacted with the stem-cell marker NANOG, and this interaction has recently been shown to play a critical role in regulating progression of prostate cancer. We showed that, in one patient with pancreatic cancer, the expression of a truncated form of SPOP (p.Q360*) lacking the nuclear localization signal led to nuclear accumulation of NANOG, which promoted growth and metastasis of pancreatic cancer cells. Our results suggest that SPOP suppresses progression of pancreatic cancer by promoting the ubiquitination and subsequent degradation of NANOG. These results identify the SPOP-NANOG interaction as a potential therapeutic target against pancreatic cancer.
Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2
Authors: Zhang Xuan , Zhang Yi , He Zhongyuan , Yin Kai , Li Bowen , Zhang Lu , Xu Zekuan 
Published: October 2019

AbstractAn increasing number of studies indicate that adrenergic signalling plays a fundamental role in chronic stress-induced tumour progression and metastasis. However, its function in gastric cancer (GC) and its potential mechanisms remain unknown. The expression levels of β-adrenergic receptor (ADRB) in GC cell lines were examined by using real-time polymerase chain reaction (RT-PCR) and western blotting. The effects of β2 adrenergic receptor (ADRB2) activation and blockade were investigated in vitro in GC cells by using proliferation, migration, invasion, cell cycle and apoptosis assays. Chronic restraint stress (CRS) increased the plasma levels of catecholamines and cortisol and also induced progression and metastasis of GC in vivo. Furthermore, immunohistochemical staining and a TUNEL assay were employed to observe the regulation of cell viability in vivo. The expression levels of ADRB2 in 100 human GC samples were measured by RT-PCR and immunohistochemistry. The stress hormones epinephrine and norepinephrine significantly accelerated GC cell proliferation, invasion and viability in culture, as well as tumour growth in vivo. These effects were reversed by the ADRB antagonists propranolol and ICI118,551 (an ADRB2-specific antagonist). Moreover, the selective ADRB1 antagonist atenolol had almost no effect on tumour cell proliferation and invasion in vitro and in vivo. ADRB2 antagonists suppressed proliferation, invasion and metastasis by inhibiting the ERK1/2-JNK-MAPK pathway and transcription factors, such as NF-κB, AP-1, CREB and STAT3. Analysis of xenograft models using GC cells revealed that ADRB2 antagonists significantly inhibited tumour growth and metastasis, and chronic stress antagonized these inhibitory effects. In addition, chronic stress increased the expression of VEGF, MMP-2, MMP-7 and MMP-9 in transplanted tumour tissue, and catecholamine hormones enhanced the expression of metastasis-related proteins. The expression of ADRB2 was upregulated in tumour tissues and positively correlated with tumour size, histological grade, lymph node metastasis and clinical stage in human GC samples. Stress hormone-induced activation of the ADRB2 signalling pathway plays a crucial role in GC progression and metastasis. These findings indicate that ADRB2 signalling regulates GC progression and suggest β2 blockade as a novel strategy to complement existing therapies for GC.
An interaction-driven many-particle quantum heat engine and its universal behavior
Authors: Chen Yang-Yang , Watanabe Gentaro , Yu Yi-Cong , Guan Xi-Wen , del Campo Adolfo 
Published: October 2019

AbstractA quantum heat engine (QHE) based on the interaction driving of a many-particle working medium is introduced. The cycle alternates isochoric heating and cooling strokes with both interaction-driven processes that are simultaneously isochoric and isentropic. When the working substance is confined in a tight waveguide, the efficiency of the cycle becomes universal at low temperatures and governed by the ratio of velocities of a Luttinger liquid. We demonstrate the performance of the engine with an interacting Bose gas as a working medium and show that the average work per particle is maximum at criticality. We further discuss a work outcoupling mechanism based on the dependence of the interaction strength on the external spin degrees of freedom.
High-density EEG mobile brain/body imaging data recorded during a challenging auditory gait pacing task
Authors: Wagner Johanna , Martinez-Cancino Ramon , Delorme Arnaud , Makeig Scott , Solis-Escalante Teodoro , Neuper Christa , Mueller-Putz Gernot 
Published: October 2019

AbstractIn this report we present a mobile brain/body imaging (MoBI) dataset that allows study of source-resolved cortical dynamics supporting coordinated gait movements in a rhythmic auditory cueing paradigm. Use of an auditory pacing stimulus stream has been recommended to identify deficits and treat gait impairments in neurologic populations. Here, the rhythmic cueing paradigm required healthy young participants to walk on a treadmill (constant speed) while attempting to maintain step synchrony with an auditory pacing stream and to adapt their step length and rate to unanticipated shifts in tempo of the pacing stimuli (e.g., sudden shifts to a faster or slower tempo). High-density electroencephalography (EEG, 108 channels), surface electromyography (EMG, bilateral tibialis anterior), pressure sensors on the heel (to register timing of heel strikes), and goniometers (knee, hip, and ankle joint angles) were concurrently recorded in 20 participants. The data is provided in the Brain Imaging Data Structure (BIDS) format to promote data sharing and reuse, and allow the inclusion of the data into fully automated data analysis workflows.
Intelligibility of Children With Speech Sound Disorders Evaluated by Listeners With Swedish as a Second Language
Authors: Lagerberg Tove B. , Lam Jenny , Olsson Rikard , Abelin Åsa , Strömbergsson Sofia 
Published: October 2019

Purpose
This study aimed to investigate the intelligibility of children's atypical speech in relation to listeners' language background.

Method

Forty-eight participants listened to and transcribed isolated words repeated by children with speech sound disorders. Participants were divided into, on the one hand, a multilingual group (
n
= 29) that was further divided into subgroups based on age of acquisition (early, 0–3 years; intermediate, 4–12 years; and late, > 12 years) and, on the other hand, a monolingual comparison group (
n
= 19).

Results
The monolingual listeners obtained higher intelligibility scores than the multilingual listeners; this difference was statistically significant. Participants who acquired Swedish at an older age (> 4 years) were found to have lower scores than other listeners. The later the age of acquisition, the less of the atypical speech was decoded correctly. A further analysis of the transcriptions also revealed a higher level of nonwords among the incorrect transcriptions of the multilinguals than that of the monolinguals who used more real words, whereas both groups were equally prone to using blanks when they did not perceive a word.

Conclusions
This indicates a higher risk of communicative problems between late acquirers of Swedish and children with speech sound disorders. Clinical implications, such as involving communication partners in the intervention process, are discussed as well as possible linguistic explanations to the findings. This study could be seen as a starting point in the field of research regarding the relations between the language background of the listener and the ability to perceive atypical speech.
Efficacy of Conversation Training Therapy for Patients With Benign Vocal Fold Lesions and Muscle Tension Dysphonia Compared to Historical Matched Control Patients
Authors: Gillespie Amanda I. , Yabes Jonathan , Rosen Clark A. , Gartner-Schmidt Jackie L. 
Published: October 2019

PurposeConversation training therapy (CTT) is the 1st voice therapy approach to eliminate the traditional therapeutic hierarchy and use patient-driven conversation as the sole therapeutic stimulus. The purpose of this investigation was to determine the efficacy of CTT compared to standard-of-care voice therapy approaches for the treatment of patients with voice disorders.MethodA prospective study of CTT treatment outcomes in adults with dysphonia due to primary muscle tension dysphonia or benign vocal fold lesions compared to age, gender, and diagnosis historical matched control (HMC) patients was used. The primary outcome was change in Voice Handicap Index–10 (VHI-10); secondary outcomes included acoustic, aerodynamic, and auditory-perceptual outcomes. Data were collected before treatment (baseline), at the start of each therapy session, 1 week after the final therapy session (short-term follow-up), and 3 months after the final therapy session (long-term follow-up).ResultsFor the CTT group, statistically significant improvements were observed for VHI-10. Though statistically significant improvements were observed for the VHI-10 for the HMC group, the CTT group saw significantly greater improvement in VHI-10. Furthermore, equivalent gains were observed following only 2 sessions of CTT compared to 4–8 sessions of traditional therapy. Significant improvements in the CTT group were observed for cepstral peak prominence in a vowel, fundamental frequency, Cepstral Spectral Index of Dysphonia in a vowel and connected speech, vocal intensity, average airflow in speech in a reading passage, number of breaths and duration of reading passage, and auditory-perceptual measurement of overall voice severity.ConclusionsResults support the hypothesis that training voice techniques in the context of spontaneous conversational speech improves patient perception of voice handicap and acoustic, aerodynamic, and auditory-perceptual voice outcomes both immediately following treatment and at long-term follow-up. CTT participants also demonstrated significantly larger decreases in VHI-10 compared to HMC participants who received standard-of-care, nonconversational, hierarchical-based voice therapy.