bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open Wave Height Logger: An open source pressure sensor data logger for wave measurement
Authors: Lyman Theodore P. , Elsmore Kristen , Gaylord Brian , Byrnes Jarrett E. K. , Miller Luke P. 
Published: June 2020

AbstractWave‐generated flows, associated hydrodynamic forces, and disturbances created by them play critical roles in determining the structure and health of near‐shore coastal ecosystems. Oscillatory motions produced by waves increase delivery of nutrients and food to benthic organisms, and can enhance vertical mixing to facilitate delivery of larvae and spores to the seafloor. At the same time, wave disturbances can remove individuals and biomass with far‐reaching effects on critical coastal ecosystems and the biodiversity within them. Commercial instruments designed to measure wave characteristics and the effects of wave energy can be expensive to purchase and deploy, limiting their use in large quantities or in areas where they may be lost. We have developed an inexpensive open‐source pressure transducer data logger based on an Arduino microcontroller that can be used to characterize wave conditions for deployments lasting multiple months. Our design criteria centered around simplicity, longevity, low cost, and ease of use for researchers. Housed in ubiquitous polyvinylchloride (PVC) plumbing and constructed primarily with readily available materials, the Open Wave Height Logger (OWHL) can be fabricated in a college setting with basic shop tools. The OWHL performs comparably to commercial pressure‐based wave height data loggers during tests in the field, creating the opportunity to expand the use of these sensors for applications where sufficient spatial replication or risk of instrument loss would otherwise be cost prohibitive.
The differentiation operator in the space of uniformly convergent Dirichlet series
Authors: Bonet José 
Published: June 2020

AbstractContinuity, compactness, the spectrum and ergodic properties of the differentiation operator are investigated, when it acts in the Fréchet space of all Dirichlet series that are uniformly convergent in all half‐planes for each . The properties of the formal inverse of the differentiation are also investigated.
A timeline of female stress urinary incontinence: how technology defined theory and advanced treatment
Authors: Schreiner Gretchen , Beltran Rylee , Lockwood Gina , Takacs Elizabeth B. 
Published: June 2020

AbstractBackgroundPrevailing theories and treatments of female stress urinary incontinence are built on 120 years of evolution in understanding the structure and function of the female bladder neck and urethra and of considering why treatments failed. In our management of patients, it is important to understand and appreciate how our management of female stress urinary incontinence has evolved and which treatments have prevailed as we advance our knowledge for future treatments.AimsThe purpose of this review is to describe how advances in technology impacted and shaped prevailing theories or understanding of the pathophysiology of stress urinary incontinence and influences our treatment approach.Materials and MethodsAn extensive literature search was performed from 1900 to present identifying articles that discussed technological advancements in female urology, theories of female stress incontinence, and treatments.ResultsThe literature from the 20th century to the present shows a nonlinear evolution of the pathophysiological mechanism of stress urinary incontinence (SUI) from a notion of SUI and secondary to a simple anatomic finding to consideration of the effects of neurophysiologic pathways on SUI. Slings, however, have been a staple in the management of SUI.ConclusionsThe pubovaginal sling (PVS) is a procedure that, with minor modifications (graft size, suture preference) has withstood the test of time and maintained its place in the armamentarium of SUI treatment for 100 years. It is therefore imperative that we continue to educate our residents and fellows on the surgical techniques and indications for use of the PVS.
Best practices for cystometric evaluation of lower urinary tract function in muriform rodents
Authors: Fraser Matthew O. , Smith Phillip P. , Sullivan Maryrose P. , Bjorling Dale E. , Campeau Lysanne , Andersson Karl‐Erik , Yoshiyama Mitsuharu 
Published: June 2020

AbstractAimsRodent cystometry has provided valuable insights into the impact of the disease, injury, and aging on the cellular and molecular pathways, neurologic processes, and biomechanics of lower urinary tract function. The purpose of this white paper is to highlight the benefits and shortcomings of different experimental methods and strategies and to provide guidance on the proper interpretation of results.MethodsLiterature search, selection of articles, and conclusions based on discussions among a panel of workers in the field.ResultsA range of cystometric tests and techniques used to explore biological phenomena relevant to the lower urinary tract are described, the advantages and disadvantages of various experimental conditions are discussed, and guidance on the practical aspects of experimental execution and proper interpretation of results are provided.ConclusionsCystometric evaluation of rodents comprises an extensive collection of functional tests that can be performed under a variety of experimental conditions. Decisions regarding which approaches to choose should be determined by the specific questions to be addressed and implementation of the test should follow standardized procedures.
Lung fibrosis enters the iron age†
Authors: Ogger Patricia P , Byrne Adam J 
Published: June 2020

AbstractIron is an essential nutrient for numerous cellular processes. However, excess iron in the lung (e.g. inhaled in pollution/cigarette smoke) can be harmful, acting as a catalyst in the formation of free radicals. Pulmonary iron content is therefore tightly regulated and alterations in iron metabolism have been associated with chronic lung disease. In particular, patients with idiopathic pulmonary fibrosis have been reported to have numerous aspects of dysfunctional iron metabolism in the lung, including increased iron levels, presence of iron‐laden macrophages and iron‐induced oxidative stress. In a recent issue of The Journal of Pathology, Ali et al showed a mechanistic link between iron accumulation and pulmonary fibrosis pathology. Using mouse models of iron overload, the authors showed that increased iron levels resulted in reduced lung function and worse pulmonary fibrosis upon lung injury by bleomycin. Treatment with inhaled iron chelator deferoxamine ameliorated pulmonary fibrosis and prevented lung function decline in vivo. This study highlights the importance of iron homeostasis in the lung and provides evidence of pulmonary iron overload contributing to the development and progression of pulmonary fibrosis. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Electromagnetic shielding effectiveness improvement with high temperature in far‐field behavior multiwall carbon nanotube/iron (III) particles addition in composites
Authors: Merizgui Tahar , Hadjadj Abdechafik , Kious Mecheri , Gaoui Bachir 
Published: June 2020

AbstractThe hybrid polymer composite (HPMC) are increasingly used in the most shielding applications in the far field region, but the main problem is these HPMC should be having a good shielding efficiency and works at high temperature. The purpose of this research study was to prepare a high stable microwave shielding hybrid polymer composite for incremental temperature implementations with surface modified MWCNTs and Fe2O3 filled contents. In this paper, the kenaf fiber, Iron (III) oxide and MWCNTs particles were surface‐treated by APTMS for effective dispersion and adhesion on epoxy matrix medium. The morphology of the obtained shields was investigated by scanning electron microscopy. Thus, additions of MWCNTs and Iron (III) oxide particles increase the magnetic permeability and electrical permittivity of epoxy polymer matrix at high temperature (25°C‐100°C‐200°C). The kenaf fibers increase the mechanical properties such as the flexural, tensile. The principal advantages of these compositions are its low cost and its higher electrical conductivity which make it a suitable material as shielding material against electromagnetic field at high temperature. For electromagnetic compatibility in the far‐field regions, the adequate SE in the frequency range of 2 to 18 GHz of the epoxy polymer matrix‐kenaf fiber conducting composites was obtained by adding the MWCNT and Fe2O3 particles.
Quality assessment of Typhae Pollen Carbonisata based on chromaticity analysis combined with UPLC fingerprinting and thrombin activity
Authors: Ren Kun , Fei Zhongping , Wang Yannian , Cheng Xile , Wang Dongmei , Lu Yan , Ren Shumeng , Pan Yingni , Liu Xiaoqiu 
Published: June 2020

AbstractIntroductionTyphae pollen (TP) has been used as an anticoagulant in traditional Chinese medicine and throughout Asia. Typhae Pollen Carbonisata (TPC), a processed product of TP, has hemostatic properties. TPC is produced by frying TP, and the degree of processing can be judged by the colour change from yellow to brown.ObjectiveTo establish a novel method for quality assessment of TPC and discriminate TPC from underdone products and overdone products.MethodologyThe Commission Internationale de l’Eclairage (CIE) L* a* b* colour space values of TP and TPC were measured to establish the colour model of TPC. Ultra‐performance liquid chromatography was developed for fingerprinting. Thrombin activity promoting rates, clotting time, and bleeding time illustrated the difference in the hemostatic effect of the processed products. Chemometric approaches were performed to reveal the correlation between components and colour values or thrombin activity.ResultsReference ranges of colour values and mathematical functions of TPC were established. The developed method was found to be fast, economic, sensitive, and stable. Fingerprints and thrombin activity in conjunction with partial least squares (PLS) demonstrated that peaks 2, 4, 7, 30, and 36 (isorhamnetin) were the main contributors for colour values and hemostatic activity of TPC.ConclusionsTPC and its unqualified products can be effectively distinguished based on chromaticity analysis, which provides a powerful tool for the comprehensive evaluation of the quality of Chinese herbal medicines.
Prenatal exposure to VOCs and NOx and lung function in preschoolers
Authors: Gutiérrez‐Delgado Rosa I. , Barraza‐Villarreal Albino , Escamilla‐Núñez María C. , Hernández‐Cadena Leticia , Cortez‐Lugo Marlene , Sly Peter , Romieu Isabelle 
Published: June 2020

AbstractBackgroundSeveral studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life.MethodsWe included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega‐3 fatty acid Supplements, GRowth, And Development birth cohort study with the aim to evaluate the impact of prenatal exposure to volatile organic compounds and nitrogen oxides on lung function measured by oscillation tests. The preschoolers were followed until 5 years of age. Anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. Information on sociodemographic and health characteristics was obtained during follow up. Prenatal exposure to volatile organic compounds and nitrogen oxides was evaluated using a land use regression models and the association between them was tested using a lineal regression and longitudinal linear mixed effect models adjusting for potential confounders.ResultsOverall, the mean (standard deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10 Hz during the follow‐up period was 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and –5.2 (1.6), –4.8 (1.7), and –4.6 hPa s L−1 (1.6), respectively. We found a significantly positive association between respiratory resistance (βRrs6 = 0.011; 95%CI: 0.001, 0.023) (P < .05) and prenatal exposure to nitrogen dioxide and a marginally negatively association between respiratory reactance (βXrs6 = −11.40 95%CI: −25.26, 1.17 and βXrs8 = −11.91 95%CI: −26.51, 1.43) (P = .07) and prenatal exposure to xylene.ConclusionPrenatal exposure to air pollutants was significantly associated with the alteration of lung function measured by oscillation tests in these preschool children.
Selenium‐binding protein 1 alters energy metabolism in prostate cancer cells
Authors: Elhodaky Mostafa , Hong Lenny K. , Kadkol Shrinidhi , Diamond Alan M. 
Published: June 2020

AbstractObjectiveThe broad goal of the research described in this study was to investigate the contributions of selenium‐binding protein 1 (SBP1) loss in prostate cancer development and outcome.MethodsSBP1 levels were altered in prostate cancer cell lines and the consequences on oxygen consumption, expression of proteins associated with energy metabolism, and cellular transformation and migration were investigated. The effects of exposing cells to the SBP1 reaction products, H2O2 and H2S were also assessed. In silico analyses identified potential HNF4α binding sites within the SBP1 promoter region and this was investigated using an inhibitor specific for that transcription factor.ResultsUsing in silico analyses, it was determined that the promoter region of SBP1 contains putative binding sites for the HNF4α transcription factor. The potential for HNF4α to regulate SBP1 expression was supported by data indicating that HNF4α inhibition resulted in a dose‐response increase in the levels of SBP1 messenger RNA and protein, identifying HNF4α as a novel negative regulator of SBP1 expression in prostate cancer cells. The consequences of altering the levels of SBP1 were investigated by ectopically expressing SBP1 in PC‐3 prostate cancer cells, where SBP1 expression attenuated anchorage‐independent cellular growth and migration in culture, both properties associated with transformation. SBP1 overexpression reduced oxygen consumption in these cells and increased the activation of AMP‐activated protein kinase (AMPK), a major regulator of energy homeostasis. In addition, the reaction products of SBP1, H2O2, and H2S also activated AMPK.ConclusionsBased on the obtained data, it is hypothesized that SBP1 negatively regulates oxidative phosphorylation (OXPHOS) in the healthy prostate cells by the production of H2O2 and H2S and consequential activation of AMPK. The reduction of SBP1 levels in prostate cancer can occur due to increased binding of HNF4α, acting as a transcriptional inhibitor to the SBP1 promoter. Consequently, there is a reduction in H2O2 and H2S‐mediated signaling, inhibition of AMPK, and stimulation of OXPHOS and building blocks of biomolecules needed for tumor growth and progression. Other effects of SBP1 loss in tumor cells remain to be discovered.
Securinine suppresses osteoclastogenesis and ameliorates inflammatory bone loss
Authors: Kwak Sung Chul , Jeong Da Hye , Cheon Yoon‐Hee , Lee Chang Hoon , Yoon Kwon‐Ha , Kim Ju‐Young , Lee Myeung Su 
Published: June 2020

AbstractSecurinine (Sec) is a naturally derived compound separated from the roots of Securinega suffruticosa, which has long been used as a herbal medicine. Sec is widely known as a GABA receptor antagonist, it is also known as an innate immune cell agonist and has been reported to increase macrophage activity and promote monocyte maturation. On the basis of these studies, we investigated the effect of Sec on osteoclast differentiation and bone resorbing function. We have found that Sec inhibits RANKL‐induced osteoclast differentiation, fusion, actin ring formation, and bone resorbing function by the inhibition of gene expression associated with each stage. Moreover, Sec significantly suppressed osteoclastogenesis by decreasing the phosphorylation of p38, Akt, JNK, IκB, and PLCγ2, in pathways involved in early osteoclastogenesis as well as through the subsequent suppression of c‐Fos and NFATc1. Finally, Sec effectively protected bone loss induced by the excessive inflammatory responses and activity of osteoclasts in vivo by a micro‐CT and histological analysis. In conclusion, our findings suggest that Sec may be a promising drug for bone metabolic diseases such as osteoporosis, which is associated with the excessive activity of osteoclasts.
Multiresponse optimization of a multistage manufacturing process using a patient rule induction method
Authors: Lee Dong‐Hee , Yang Jin‐Kyung , Kim Kwang‐Jae 
Published: June 2020

AbstractMost manufacturing industries produce products through a series of sequential stages, known as a multistage process. In a multistage process, each stage affects the stage that follows, and the process often has multiple response variables. In this paper, we suggest a new procedure for optimizing a multistage process with multiple response variables. Our method searches for an optimal setting of input variables directly from operational data according to a patient rule induction method (PRIM) to maximize a desirability function, to which multiple response variables are converted. The proposed method is explained by a step‐by‐step procedure using a steel manufacturing process as an example. The results of the steel manufacturing process optimization show that the proposed method finds the optimal settings of input variables and outperforms the other PRIM‐based methods.
Robotic Whipple for pancreatic ductal and ampullary adenocarcinoma: 10 years experience of a US single‐center
Authors: Valle Valentina , Fernandes Eduardo , Mangano Alberto , Aguiluz Gabriela , Bustos Roberto , Bianco Francesco , Giulianotti Pier Cristoforo 
Published: June 2020

AbstractBACKGROUNDThere is currently ample consensus about the safety and feasibility of robotic pancreaticoduodenectomy (RPD). However, few studies are available on the long‐term oncological outcomes of this procedure. We present a long‐term survival analysis (up to 10 years) of our series of RPD carried out for ductal and ampullary adenocarcinoma.METHODSA retrospective analysis of a prospectively collected approved database was carried out including 39 patients who underwent RPD for pancreatic ductal and ampullary adenocarcinomas.RESULTSThe 5‐year overall survival for ductal and ampullary carcinoma was 41% with an estimated median and mean survival of 27 and 52 months. The ampullary group had significantly longer 5‐year survival (68%) than the ductal group (30%).CONCLUSIONOur data show, within the limitations of their retrospective nature, that robotic pancreaticoduodenectomy provides similar short‐ and long‐term survival outcomes compared to open technique in the treatment of pancreatic ductal and ampullary adenocarcinoma.
Recursive filtering adaptive fault‐tolerant tracking control for uncertain switched multivariable nonlinear systems
Authors: Ma Tong 
Published: June 2020

SummaryThis article synthesizes a recursive filtering adaptive fault‐tolerant tracking control method for uncertain switched multivariable nonlinear systems. The multivariable nonlinear systems under consideration have both matched and mismatched uncertainties, which satisfy the semiglobal Lipschitz condition. A piecewise constant adaptive law generates adaptive parameters by solving the error dynamics with the neglection of unknowns, and the recursive least squares is employed to minimize the residual error by categorizing the total uncertainty estimates into matched and mismatched components. A filtering control law is designed to compensate the actuator faults and nonlinear uncertainties such that a good tracking performance is delivered with guaranteed robustness. The matched component is canceled directly by adopting their opposite in the control signal, whereas a dynamic inversion of the system is performed to eliminate the effect of the mismatched component on the output. By exploiting the average dwell time principle, the error bounds are derived for the states and control inputs compared with the virtual reference system which defines the best performance that can be achieved by the closed‐loop system. Both numerical and practical examples are provided to illustrate the effectiveness of the proposed switching recursive filtering adaptive fault‐tolerant tracking control architecture, comparisons with model reference adaptive control are also carried out.
Decentralized filtering adaptive constrained tracking control for interconnected nonlinear systems
Authors: Ma Tong 
Published: June 2020

SummaryThis paper presents a novel decentralized filtering adaptive constrained tracking control framework for uncertain interconnected nonlinear systems. Each subsystem has its own decentralized controller based on the established decentralized state predictor. For each subsystem, a piecewise constant adaptive law will generate total uncertainty estimates by solving the error dynamics between the host system and decentralized state predictor with the neglection of unknowns, whereas a decentralized filtering control law is designed to compensate both local and mismatched uncertainties from other subsystems, as well as achieve the local objective tracking of the host system. The achievement of global objective depends on the achievement of local objective for each subsystem. In the control scheme, the nonlinear uncertainties are compensated for within the bandwidth of low‐pass filters, while the trade‐off between tracking and constraints violation avoidance is formulated as a numerical constrained optimization problem which is solved periodically. Priority is given to constraints violation avoidance at the cost of deteriorated tracking performance. The uniform performance bounds are derived for the system states and control inputs as compared to the corresponding signals of a bounded closed‐loop reference system, which assumes partial cancelation of uncertainties within the bandwidth of the control signal. Compared with model predictive control (MPC) and unconstrained controller, the proposed control architecture is capable of solving the tracking control problems for interconnected nonlinear systems subject to constraints and uncertainties.
Objective identification of local spatial structure for material characterization
Authors: Yu Youjiao , Gorman Brian P. , Hering Amanda S. 
Published: June 2020

AbstractObjective tools for characterizing materials at the atomic level are often difficult to develop because of the size or structure of the data. Atom probe tomography (APT) is a measurement tool that maps the location and type of atoms in materials in three‐dimensions (3D), producing data sets with potentially billions of observations. In this work, we present a set of spatial statistics methods developed to test the null hypotheses of no global spatial association; no local spatial association; and no local spatial cross‐correlation and apply these for the first time to APT data. The empirical and modeled covariogram and Moran's I can be used to study the global structure of a spatially referenced atomic element. The local indicator of spatial association (LISA) identifies volumes where high levels of values (hot spots) or low levels of values (cold spots) of elemental clustering exist. The local indicator of spatial cross‐correlation (LISC) reports where simultaneously high levels or low levels of two atomic elements occur. For each test statistic at each location, an associatedp‐value is produced that can be used to weigh the evidence in favor of spatial clustering. The size of APT data sets presents some challenges, so the effect of weight functions and neighborhood selection on the computation and significance of the test statistics are discussed, and the issue of multiple statistical testing is also considered. These methods are illustrated using an APT data set with atomic percentages reported in voxels binned to 1 nm3.