bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epizootic neoplasia in a managed population of Atlantic bumper fish, Chloroscombrus chrysurus (Osteichthyes: Carangidae), at a public aquarium
Authors: Stilwell Justin M. , Boylan Shane M. , Vorbach Bryan , Camus Alvin C. 
Published: December 2020

AbstractAdvances in fish medicine and husbandry have increased the average lifespans of specimens in managed aquarium populations. As a result, an increased incidence and variety of neoplasia is expected. This work characterizes diverse neoplasms arising within a managed population of Atlantic bumper fish acquired via repeated collections from the Charleston Harbor region. A total of 76 neoplasms were evaluated histologically from 41 of 45 fish that died or were killed over a 46‐month period, including cutaneous hemangiomas and hemangiosarcomas, lepidocytomas and lepidosarcomas, fibromas, vertebral body or cutaneous osteomas, disseminated lymphomas, testicular leiomyomas, cutaneous or branchial fibrosarcomas, myxomas, fibroblastic lepidosarcoma, teratoid medulloepithelioma, ganglioglioma, malignant nerve sheath tumour, cardiac rhabdomyoma, cutaneous rhabdomyosarcoma, soft tissue sarcoma and renal adenoma. Perioral and cutaneous lesions of vascular and scale origin were observed most frequently. Other, often malignant, neoplasms arose within these benign lesions, resulting in extensive local tissue invasion. However, excluding disseminated lymphomas, metastasis was only detected in one case of hemangiosarcoma. These findings suggest early surgical intervention may limit tissue destruction and loss of display quality. This report details a variety of common and rare neoplasms in fish, as well as the first characterizations of neoplasia in Atlantic bumper and ganglioglioma in fish.
Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11
Authors: Vats Nisha , Dubey Ravi Chandra , Sanal Madhusudana Girija , Taneja Pankaj , Venugopal Senthil Kumar 
Published: December 2020

Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs. Drugs such as rifampicin and glibenclamide inhibit BSEP. Progressive familial intrahepatic cholestasis type-2, a lethal pediatric disease, some forms of intrahepatic cholestasis of pregnancy, and drug-induced cholestasis are associated with BSEP dysfunction. Methods: We started with a bioinformatic approach to identify the relationship between ABCB11 and other proteins, microRNAs, and drugs. A microarray data set of the liver samples from ABCB11 knockout mice was analyzed using GEO2R. Differentially expressed gene pathway enrichment analysis was conducted using ClueGo. A protein-protein interaction network was constructed using STRING application in Cytoscape. Networks were analyzed using Cytoscape. CyTargetLinker was used to screen the transcription factors, microRNAs and drugs. Predicted drugs were validated on human liver cell line, HepG2. BSEP expression was quantified by real-time PCR and western blotting. Results: ABCB11 knockout in mice was associated with a predominant upregulation and downregulation of genes associated with cellular component movement and sterol metabolism, respectively. We further identified the hub genes in the network. Genes related to immune activity, cell signaling, and fatty acid metabolism were dysregulated. We further identified drugs (glibenclamide and ATP) and a total of 14 microRNAs targeting the gene. Western blot and real-time PCR analysis confirmed the upregulation of BSEP on the treatment of HepG2 cells with glibenclamide, ATP, and metformin. Conclusions: The differential expression of cell signaling genes and those related to immune activity in ABCB11 KO animals may be secondary to cell injury. We have found glibenclamide, ATP, and metformin upregulates BSEP. The mechanisms involved and the clinical relevance of these findings need to be investigated.
Separation of HCl/water mixture using air gap membrane distillation, Taguchi optimization and artificial neural network
Authors: Kalla Sarita , Baghel Rakesh , Upadhyaya Sushant , Singh Kailash 
Published: December 2020

Abstract
The aim of this paper is to analyze the performance of the air gap membrane distillation (AGMD) process for the separation of HCl/Water mixture first by applying Taguchi optimization approach and second by developing an artificial neural network (ANN) model. The experimental data which are fed as input to the above approaches are collected from the fabricated AGMD lab-scale setup using poly-tetra-fluoro-ethylene membrane of 0.22 µm pore size. The process input variables considered are bulk feed temperature, feed flow rate, air gap thickness, cooling water temperature and cooing water flow rate and AGMD performance index is the total permeate flux. The optimum operating condition is found to be at feed temperature 50 °C, air gap thickness 7 mm, cooling water temperature 5 °C and feed flow rate 10 lpm. Analysis of variance test is carried out for both Taguchi and ANN models. Regression model has also been developed for the comparison between experimental and model predicted data. The developed ANN model has been found well fitted with experimental data having R
2 value of 0.998. Based on the calculated percentage of contribution of each input parameter on the AGMD permeate flux, it can be concluded that feed temperature and air gap thickness have highest weightage whereas feed flow rate and cooling water temperature have moderate effects. Predictive ability of the developed ANN model is further checked with 2D contour plot. The distinctive feature of the paper is the development of the Taguchi experimental design and ANN model and then consequently integration of both Taguchi and ANN has been carried out to optimized the developed ANN model parameters.
Population attributable fractions for continuously distributed exposures
Authors: Ferguson John , Maturo Fabrizio , Yusuf Salim , O’Donnell Martin 
Published: December 2020

Abstract
When estimating population attributable fractions (PAF), it is common to partition a naturally continuous exposure into a categorical risk factor. While prior risk factor categorization can help estimation and interpretation, it can result in underestimation of the disease burden attributable to the exposure as well as biased comparisons across different exposures and risk factors. Here, we propose sensible PAF estimands for continuous exposures under a potential outcomes framework. In contrast to previous approaches, we incorporate estimation of the minimum risk exposure value (MREV) into our procedures. While for exposures such as tobacco usage, a sensible value of the MREV is known, often it is unknown and needs to be estimated. Second, in the setting that the MREV value is an extreme-value of the exposure lying in the distributional tail, we argue that the natural estimator of PAF may be both statistically biased and highly volatile; instead, we consider a family of modified PAFs which include the natural estimate of PAF as a limit. A graphical comparison of this set of modified PAF for differing risk factors may be a better way to rank risk factors as intervention targets, compared to the standard PAF calculation. Finally, we analyse the bias that may ensue from prior risk factor categorization, examining whether categorization is ever a good idea, and suggest interpretations of categorized-estimands within a causal inference setting.
Cansancio, oralidad y Mündigkeit en Macunaíma
Authors: Fernández Hans 
Published: December 2020

Resumen
El presente artículo analiza tres aspectos de la configuración estética e ideológica de la novela brasileña Macunaíma de Mário de Andrade: primero la terca negación a hablar del trickster amazónico. Segundo la crítica ejercida, por medio de un posicionamiento a favor de la oralidad, en contra de los grupos hegemónicos de Brasil (quienes al dominar la lengua escrita “falam numa língua e escrevem noutra”), la que representa en el fondo el deseo de una expresión literaria propia, y, por último, la superación alegórica —relacionada con los aspectos anteriores— del estado de Unmündigkeit de su protagonista.
Sobre la alternancia así que ~ así es que en español actual
Authors: Pato Enrique 
Published: December 2020

Resumen
El presente estudio ofrece una descripción razonada de la alternancia que tiene lugar entre las locuciones conjuntivas así que y así es que en español actual, aspecto que no había sido tratado con anterioridad en ningún trabajo gramatical. En primer lugar, se revisa el significado de estas dos formas, uno consecutivo y otro temporal, así como los contextos de uso en los que forman parte: los tiempos verbales con los que suelen aparecer, su posición dentro de la frase, la posibilidad de combinación con otros nexos y conectores, la forma dequeísta (así es de que) y su origen y evolución. En segundo lugar, se presenta su distribución geográfica y se establece una comparación de uso entre los diversos países hispanohablantes. Para ello empleo los datos del CORPES XXI, datos que se analizan desde el punto de vista estadístico mediante la frecuencia normalizada de cada una de las locuciones y una prueba de análisis de varianza. Los resultados muestran una diferencia de empleo en el caso de así es que, uso favorecido en la variedad chilena. Este hecho mostraría un caso concreto del pluricentrismo de la lengua española.
The translation of affirmative action into legal discourse in Brazil
Authors: Frade Celina 
Published: December 2020

Abstract
Several studies have recently discussed legal translation beyond the transfer of equivalent linguistic and terminological features from a source language to a target language. Such perspectives can provide linguistics, translators and legislators with a framework for translating outside events of social life, including its demands, knowledge, wishes and cultural developments throughout periods of time into legal discourse. In this paper, we aim to discuss a broader approach of legal translation to depict how public policies on affirmative action have been introduced in Brazil in the light of institutionalization and further instrumentalization by law. In particular, we make an attempt to show how domestic legislation is translated and enacted considering both the context (as the source ‘language’) and legal discourse (as the target language). Our claim is that the process entails a transformation or translation of context (common sense achieved by society) into legal discourse (law) by means of categorization of everyday concepts into legal concepts to meet both the socioeconomic and historical contexts at hand and the framework of written law. The analysis is based on the Rio de Janeiro state law 5346/2008, a landmark law ruling affirmative action in Brazil insofar as it expands the categories of beneficiaries – the so-called quotistas – taking into consideration the social, political and economic context then. In addition, we argue that the criterion of categorization is not arbitrary but is rather cultural, economic and historically driven and objectivates the human production of a role identity of the beneficiaries beyond subjective intentions. To conclude, this analysis was only made possible with the contribution of more comprehensive viewpoints on legal translation and the role played by social perceptions in the translatability of domestic legislation in monolingual jurisdictions.
It is Young People that Give Me Hope
Authors: Feyen Christoph 
Published: December 2020

Abstract
Seventy-seven years after gaining independence and 11 years after the end of a long civil war, Sri Lankan public discourse is still searching for a broadly accepted concept of national identity and struggling to find constructive ways of dealing with the past. In this interview the former president of Sri Lanka (1994–2005) Madam Chandrika Bandaranaike Kumaratunga reflects on deeply rooted conflicts in society, the various outbreaks of violence, political mistakes made in the past, and her own role in the peace process and in reconciliation.
Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology
Authors: Kurtul Bengi Ece , Çakmak Ayşe İdil , Elbeyli Ahmet , Karaaslan Abdulkerim , El Çiğdem 
Published: December 2020

Abstract

Objectives
To investigate the optical coherence tomography angiography (OCTA) and specular microscopy (SM) findings in obese children and compare them with healthy ones.

Methods
In this prospective study, 50 eyes of 25 obese children [body mass index (BMI) ≥95th percentile], 36 eyes of 18 control age- and sex- matched healthy subjects (BMI <85th percentile) were included. Demographic features and ophthalmological examination including OCTA measurements as well as SM findings were assessed. Cellular morphology was observed by noncontact SM and results for corneal endothelial cell density (cells/mm2), coefficient of variation of cell size and percentage of hexagonal cells were obtained. The OCTA was performed with 6 × 6 mm sections for macula and 4.5 × 4.5 mm sections for optic disc in all eyes. Foveal retinal thickness (FRT), retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of retina and optic nerve head were analyzed.

Results
All SM parameters, RNFL thickness for average, and all quadrants and optic disc radial peripapillary capillary densities were similar between groups. However, FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities were significantly higher in obese group when compared to controls (242.4 ± 18.2 µm vs. 232.1 ± 16.5 µm, p=0.024, 2.2 ± 0.1 mm2 vs, 2.2 ± 0.0 mm2, p=0.042, 22.4 ± 6.9% vs. 15.6 ± 5.5%, p=0.001, and 38.9 ± 7.5% vs. 31.1 ± 8.6 %, p=0.001, respectively).

Conclusions
Obese children seem to have higher values of FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities. These results may have significant implications for understanding of how childhood obesity could affect retinal microvasculature.
Achromatic terahertz Airy beam generation with dielectric metasurfaces
Authors: Cheng Qingqing , Wang Juncheng , Ma Ling , Shen Zhixiong , Zhang Jing , Zheng Xiaoying , Chen Tao , Yu Ye , Yu Dong , He Qiong , Hu Wei , Li Tao , Zhuang Songlin , Zhou Lei 
Published: December 2020

Abstract
Airy beams exhibit intriguing properties such as nonspreading, self-bending, and self-healing and have attracted considerable recent interest because of their many potential applications in photonics, such as to beam focusing, light-sheet microscopy, and biomedical imaging. However, previous approaches to generate Airy beams using photonic structures have suffered from severe chromatic problems arising from strong frequency dispersion of the scatterers. Here, we design and fabricate a metasurface composed of silicon posts for the frequency range 0.4–0.8 THz in transmission mode, and we experimentally demonstrate achromatic Airy beams exhibiting autofocusing properties. We further show numerically that a generated achromatic Airy-beam-based metalens exhibits self-healing properties that are immune to scattering by particles and that it also possesses a larger depth of focus than a traditional metalens. Our results pave the way to the realization of flat photonic devices for applications to noninvasive biomedical imaging and light-sheet microscopy, and we provide a numerical demonstration of a device protocol.
Crystal structure of 1,3-bis(octyl)benzimidazolium perchlorate C23H39ClN2O4
Authors: Liu Xiao-jing , Li Zhuang-yu , Liu E , Jian Fang-fang , Liang Tong-ling 
Published: December 2020

Abstract
C23H39ClN2O4, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 9.0752(19) Å, b = 9.542(2) Å, c = 16.049(3) Å, α = 99.088(4)°, β = 94.422(4)°, γ = 107.146(4)°, V = 1300.0(5) Å3, Z = 2, R
gt(F) = 0.0646, wR
ref(F
2) = 0.2298, T = 293.0 K.
Crystal structure of (Z)-3-(6-bromo-1H-indol-3-yl)-1,3-diphenylprop-2-en-1-one, C23H16BrNO
Authors: Pan Fei , Wei Xian , Lv Menglan Lan 
Published: December 2020

Abstract
C23H16BrNO, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 9.914(3) Å, b = 10.141(3) Å, c = 10.179(3) Å, α = 90.177(5)°, β = 112.202(5)°, γ = 95.167(5)°, V = 942.9(4) Å3, Z = 2, R

gt
(F) = 0.0520, wR

ref
(F
2) = 0.1351, T = 296 K.

CCDC no.: 2043972
The crystal structure of ethyl 2-amino-4-(3,5-difluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate, C20H21F2NO4
Authors: Shin Soon Young , Yoo Miri , Koh Dongsoo 
Published: December 2020

Abstract
C20H21F2NO4, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 8.6363(11) Å, b = 9.9144(11) Å, c = 11.8734(15) Å, α = 81.891(4)°, β = 72.889(4)°, γ = 80.972(3)°, V = 954.7(2) Å3, Z = 2, R

gt
(F) = 0.0466, wR

ref
(F
2) = 0.1339, T = 223(2) K.
The crystal structure of tris(2,3,4,6,7,8,9,10-octahydro-1H-pyrimido[1,2-a]azepin-5-ium) trihydrodecavanadate(V), C27H54N6O28V10
Authors: Huo Yueyang , He Qingpeng , Wang Yong 
Published: December 2020

Abstract
C27H54N6O28V10, triclinic,

P

1
‾

$P&#x203e;{1}$

(no. 2), a = 11.3803(3) Å, b = 14.0832(4) Å, c = 16.2352(7) Å, α = 91.784(3) Å, β = 104.264(3) Å, γ = 107.112(2) Å, V = 2395.04(14) Å3, Z = 2, R

gt
(F) = 0.0291, wR

ref
(F
2) = 0.0810, T = 293(2) K.
Discrete regimes of information reception in non-antagonistic repeated game
Authors: Мохонько Елена Захаровна , Mokhonko Elena 
Published: December 2020

The gain functions depend on the choices of players and time. The set of choices of the second player is changed in time according to one of some variants. The true variant is ascertained during the game. The current information about the set of choices and about partner's choices is received as sample data. An optimal discrete procedure of obtaining information is found that allows preserving the equilibrium.
Application for Public Health Accreditation Among US Local Health Departments in 2013 to 2019: Impact of Service and Activity Mix
Authors: Leider Jonathon P. , Kronstadt Jessica , Yeager Valerie A. , Hall Kellie , Saari Chelsey K. , Alford Aaron , Freeman Lori Tremmel , Kuehnert Paul 
Published: December 2020

Objectives. To examine correlates of applying for accreditation among small local health departments (LHDs) in the United States through 2019. Methods. We used administrative data from the Public Health Accreditation Board (PHAB) and 2013, 2016, and 2019 Profile data from the National Association of County and City Health Officials to examine correlates of applying for PHAB accreditation. We fit a latent class analysis (LCA) to characterize LHDs by service mix and size. We made bivariate comparisons using the t test and Pearson χ2. Results. By the end of 2019, 126 small LHDs had applied for accreditation (8%). When we compared reasons for not pursuing accreditation, we observed a difference by size for perceptions that standards exceeded LHD capacity (47% for small vs 22% for midsized [P < .001] and 0% for large [P < .001]). Conclusions. Greater funding support, considering differing standards by LHD size, and recognition that service mix might affect practicality of accreditation are all relevant considerations in attempting to increase uptake of accreditation for small LHDs. Public Health Implications. Overall, small LHDs represented about 60% of all LHDs that had not yet applied to PHAB.
Media Sosial Sebagai Sarana Pemasaran Konten Edukasi Islami Untuk Masyarakat Semarang
Authors: Rohma Siti , Sya’roni Mokh. , Mufrihah Solkhah , Arafat Ahmad Tajuddin 
Published: December 2020

<p class="ABSTRACTJUDUL"><em>The increasing use of social media (Sosmed) in Indonesia is the reason Sosmed is used as tool in marketing products and content created by institutions/agencies. A lot of research that examines media marketing through social media. The results of these studies are, it can be proven that social media is effective enough to be used as a medium in marketing products. This research uses a qualitative method with a descriptive approach. The results showed that during this pandemic, it is hoped that social media can disseminate product/content and serve as the right media to market Islamic education to the wider community, especially in the Semarang and surrounding areas.</em></p><p class="ABSTRACTJUDUL"> </p><p class="ABSTRACT">Meningkatnya penggunaan media Sosial (Medsos) di Indonesia menjadi alasan Medsos dijadikan sebagai alat dalam memasarkan produk maupun konten yang dibuat oleh lembaga/Instansi. Banyak peneliti yang mengkaji tentang pemasaran melalui media sosial (Social Media Marketing). Dari hasil penelitian tersebut dapat dibuktikan bahwa, Medsos cukup efektif untuk digunakan sebagai media dalam memasarkan produk. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Hasil penelitian menunjukkan di masa pandemi ini, Medsos dapat menyebarluaskan produk/konten dan sebagai media yang tepat untuk memasarkan konten edukasi islami kepada masyarakat luas khususnya wilayah Semarang dan sekitarnya.</p>
Solar Photovoltaic Optimal Tilt Angles in Public Building
Authors: Annibaldi Valeria , Condemi Alessia , Cucchiella Federica , Rotilio Marianna 
Published: December 2020

Abstract
The reduction of the consumption of fossil fuels that cause climate change and the encouragement of the use of cleaner renewable sources, appears to be a fundamental objective for achieving the climate aims agreed in Paris. Moreover, the sustainability of the implementation of solutions for energy efficiency in public administration buildings has played a fundamental role in recent years, strengthened also by the regulatory context of energy and environmental policies of European countries. The research fits into this context and it intends to promote a methodology that is able to evaluate the economic and environmental performance of a photovoltaic system applied in a school located in Italy when only the roof inclination angle changes. The economic and environmental performances are evaluated respectively through Life Cycle Cost Analysis and the avoided CO2 emissions. The results show that although the case study does not present the optimal roof inclination angle, there are economic and environmental advantages. Furthermore, the research notes that, considering the characteristics of the photovoltaic system concerned, the optimal roof inclination angle is equal to 40 degrees from an economic and environmental point of view. This methodology could easily support the decision-making process of designers and administrators to make the energy upgrading choices for the promotion of renewable sources. It was applied to a case study, that is a school located in Italy, in the Abruzzo region, in the province of L’Aquila, but it could be easily replicated in other existing public buildings in different locations.
SOME ASPECTS OF DEVELOPMENT OF THE HISTORIOGRAPHY OF TVER TEACHER`S SCHOOL FOR WOMEN NAMED AFTER P.P. MAKSIMOVICH AT THE MODERN STAGE
Authors: Смирнов Сергей Николаевич 
Published: December 2020

Настоящая работа является третьим компонентом цикла статей, посвященных развитию историографии учительской школы П.П. Максимовича в Твери. Рассматриваются аспекты развития историографии учительской школы, в том числе в рамках научных форумов. Отдельным сюжетом настоящей статьи является рассмотрение научных работ, подготовленных для мероприятий, организованных в Тверском государственном университете в связи со 150-летним юбилеем со дня основания школы.
This work is the third component of a series of articles devoted to the development of the historiography of the teacher's school of P.P. Maksimovich in Tver. The aspects of the development of the historiography of the teacher's school are considered here, including the examination within the framework of scientific forums. A separate plot of this article is the consideration of scientific papers prepared for events organized at Tver State University regarding the 150th anniversary of the foundation of the school.