bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors and languages in a sociohistorical context: Basque religious literature in seventeenth-century France
Authors: Zuloaga Eneko , Krajewska Dorota 
Published: November 2020

AbstractIn this paper, we apply the methods of historical sociolinguistics to seventeenth-century religious literature in Basque. We explore issues related to macrosociolinguistics, and, in particular, the problem of contextualisation of authors and their works. As an example of this approach, we analyseDoctrina Christianaby Esteve Materra (published in 1617 and 1623), the first Basque Catholic catechism in the province of Labourd, in the northern part of the Basque Country. It marked the beginning of an intense period of publishing in Basque which lasted until the late seventeenth century. We place the book in the context of major religious movements in France at that time. Materra’s catechism was a response of the Catholic Church to the Reformation in the Basque Country, and was produced with the support of the Church authorities, which needed Basque to reach monolingual speakers. Notwithstanding, Materra’s catechism also attests to the development of a model of written language to be used in the Labourdin literature.
Women’s use and acceptability of guided imagery in a multi-behavior intervention focused on psychological stress, food cravings, and exercise
Authors: Giacobbi Peter , Phillips Kylie , Shawley Samantha , Nolan Richard , Johnson Kelsey , Misra Ranjita 
Published: November 2020

Abstract

Objectives
The purpose of this short report was to describe the experiences of 29 overweight or obese women (M
age = 44) who completed a multi-behavior guided imagery intervention that simultaneously targeted psychological stress, food cravings, and physical activity behavior.

Methods
Participants created tailored guided imagery scripts with health coaches for daily use as part of the 5 week randomized controlled wait-list trial. Post-intervention semi-structured interviews were transcribed verbatim and content analyzed for common conceptual themes.

Results
The results showed that 83% of the participants stated they would continue using guided imagery, <7% would not, while the remaining 10% were unsure about future usage. The perceived usefulness varied across the three behaviors.

Conclusions
Guided imagery has the potential to simultaneously address multiple health behaviors. Our results shed light on how tailored guided imagery scripts can be used to help overweight and obese women manage or lose body weight.
Non-Equilibrium Thermodynamic Analysis of Flash Evaporation Process in Vacuum Ice Making
Authors: Zou Lingeng , Zhang Xuelai 
Published: November 2020

Abstract
Traditional equilibrium thermodynamics can only solve a few equilibrium processes composed of continuous stable equilibrium states. However, the vacuum flash evaporation process is a typical unsteady process. The study of non-equilibrium thermodynamics of the two-phase flow model is helpful to improve our understanding of the basic law of the flash evaporation process. Based on the theory of non-equilibrium thermodynamics, the flash chamber in the vacuum flash ice making system was studied in this paper, and the possibility of non-equilibrium steady state evaporation with superheat was obtained. The chemical potential difference between liquid water and water vapor under non-equilibrium steady state conditions was determined, and the corresponding evaporation entropy was calculated. It is shown that the results obtained by equilibrium thermodynamics are only related to the temperature difference, while the results obtained by non-equilibrium thermodynamics are not only related to the temperature difference, but also the state of the evaporation process. This is because non-equilibrium thermodynamics considers the cooling of liquid water and the evaporation of water vapor as a whole, taking into account the interaction between the two processes. However, the traditional equilibrium thermodynamics theory divides the steady state evaporation process into two independent processes and ignores the influence of each other.
Late diagnosis of 3β-Hydroxysteroid dehydrogenase deficiency: the pivotal role of gas chromatography-mass spectrometry urinary steroid metabolome analysis and a novel homozygous nonsense mutation in the HSD3B2 gene
Authors: Fanis Pavlos , Neocleous Vassos , Kosta Konstantina , Karipiadou Aristea , Hartmann Michaela F. , Wudy Stefan A. , Karantaglis Nikolaos , Papadimitriou Dimitrios T. , Skordis Nicos , Tsikopoulos Georgios , Phylactou Leonidas A. , Roilides Emmanouil , Papagianni Maria 
Published: November 2020

Abstract

Objectives
3β-Hydroxysteroid dehydrogenase (3β-HSD) deficiency is a rare type of congenital adrenal hyperplasia caused by recessive loss-of-function mutations in HSD3B2 gene.

Case presentation
We report an 8.5-year-old, 46XY, Roma boy with advanced adrenarche signs born to consanguineous parents. He was born at term with ambiguous genitalia. At 15 days of age, he underwent replacement therapy with hydrocortisone and fludrocortisone due to a salt wasting (SW) crisis and adrenal insufficiency. At 3.5 years, he was admitted again with SW crisis attributed to the low – unadjusted to body surface area – hydrocortisone dose and presented with bilateral gynecomastia and adrenarche. At 8.5 years, his bone age was four years more advanced than his chronological age and he was prepubertal, with very high testosterone levels. Gas chromatography-mass spectrometry (GC-MS) urinary steroid metabolome analysis revealed the typical steroid metabolic fingerprint of 3β-HSD deficiency. Sequencing of the HSD3B2 gene identified in homozygosity the novel p.Lys36Ter nonsense mutation. Furthermore, this patient was found to be heterozygous for p.Val281Leu in the CYP21A2 gene. Both parents were identified as carriers of the p.Lys36Ter in HSD3B2.

Conclusions
A novel nonsense p.Lys36Ter mutation in HSD3B2 was identified in a male patient with hypospadias. 3β-HSD deficiency due to mutations in the HSD3B2 gene is extremely rare and the finding of a patient with this rare type of disorders of sex development (DSD) is one of the very few reported to date. The complexity of such diseases requires a multidisciplinary team approach regarding the diagnosis and follow-up.
Adverse effects of metabolic disorders in childhood on adult reproductive function and fertility in the male
Authors: Wagner Isabel Viola , Oliver Elizabeth , Dötsch Jörg , Söder Olle 
Published: November 2020

AbstractOver the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by which they negatively influence male reproduction are only partly understood and published data are often controversial. Obesity is one of the most important health challenges worldwide and is becoming more prevalent in children and adolescents. Obesity, the metabolic syndrome and related co-morbidities can lead to impaired male reproductive function, including adverse effects on spermatogenesis and steroidogenesis as illustrated by reduced sperm number and quality, decreased testosterone levels and elevated inflammatory markers. The incidence of diabetes mellitus type I is also dramatically increasing and may negatively impact spermatogenesis and testicular function, resulting in decreased serum testosterone and epididymal weight. In this review, we summarize and discuss the effects of metabolic diseases that typically develop during childhood and adolescence on later reproductive function and fertility. While impact on reproductive health is likely observed in both sexes, we have chosen to focus on the male in the current review. Specifically, we illustrate adverse effects of obesity, type 1 diabetes, the metabolic syndrome and insulin resistance on sperm function and testosterone metabolism. Identification of pathophysiological mechanisms during childhood may open up new avenues for early prevention and treatment resulting in better reproductive outcomes and improved fertility rates during adulthood.
Diabetes distress in Indian children with type 1 diabetes mellitus and their mothers
Authors: Lohiya Nirali N. , Kajale Neha A. , Lohiya Nikhil N. , Khadilkar Vaman V. , Gondhalekar Ketan , Khadilkar Anuradha 
Published: November 2020

Abstract

Background
Children and their mothers, who are usually the primary caregivers, are likely to be distressed due to type 1 diabetes (T1DM).

Objectives
(1) To assess diabetes-specific distress (DD) perceived by children and adolescents with T1DM and their mothers and association of distress between children and mothers. (2) To study the association of diabetes distress with glycemic control and disease duration.

Subjects
Children and adolescents with T1DM over eight years and their mothers.

Methods
Clinical data were recorded. DD was assessed by Problem Associated in Diabetes-Pediatric (PAID-Peds) (range 0–80) and Problem Associated in Diabetes-Parents Revised (PAID-PR) (range 0–72) questionnaires (higher scores indicate higher distress); administered to children and mothers, respectively. Sub-dimensions in questionnaires included diabetes-related emotional problems, and treatment-, food-, and social support-related problems. Correlation analysis (Spearman’s) was performed, and a paired t-test was used to compare PAID-Peds and PAID-PR (SPSS 25).

Results
Mean PAID-Peds and PAID-PR scores in 67 children and mothers were 24.4 ± 18.1 and 31.9 ± 21.5, respectively (p=0.009), and a significant correlation was noted between their scores (R=0.45, p=0.001). PAID-Peds score was positively associated with HbA1c (R=0.25, p=0.04). Diabetes-related emotional problems of mothers and children (R=0.38, p=0.003), treatment problems (R=0.5, p=0.001), and food problems (R=0.24, p=0.05) correlated positively. Subdimension scores were significantly different in children and mothers except in the social support domain.

Conclusion
DD was higher in mothers than children; higher distress in children was associated with poor metabolic control. Evaluation of DD needs to be performed in children with T1DM.
Effectiveness of basal LH in monitoring central precocious puberty treatment in girls
Authors: Calcaterra Valeria , De Filippo Gianpaolo , Albertini Riccardo , Rendina Domenico , Messini Beatrice , Monti Claudio Maria , Bozzola Elena , Villani Alberto , Bozzola Mauro 
Published: November 2020

Abstract

Objectives
Treatment of central precocious puberty (CPP) is based on administration of GnRH agonists in order to suppress hypothalamic-pituitary-gonadal axis and thus induce the stabilization or regression of pubertal development. Our aim was to determine whether the single basal serum LH and/or FSH concentration could be an effective tool to assess the efficacy of treatment to suppress activation of hypothalamic-pituitary axis.

Patients and methods
Serum LH and FSH were measured before and after the GnRH injection, as well as E2 basal levels in 60 girls with documented idiopathic CPP at diagnosis and 18 and 30 months after the beginning of therapy.

Results
At diagnosis, peaks of >5 IU/L of LH and of FSH were observed in 100 and 91.6% of girls, respectively, with basal LH values of <1 IU/L in 70% and basal FSH levels of <1 IU/L in 10%. E2 were <20 pg/mL in 36.6%. After 18 months, a suppressed peak (i.e. <3 IU/L) was recorded in 85% of girls (p<0.01) for LH and in 98.3% for FSH (p<0.01). Basal LH <1 IU/L was detected in 85% (p<0.01) and basal FSH ≤1 IU/L in 40% (p<0.01). Serum E2 ≤20 pg/mL was recorded in 61.6% (p<0.01). After 30 months, all patients showed LH suppressed peak (p<0.01) and 98.3% suppressed FSH peak (p<0.01). 100% showed basal LH concentrations <1 IU/L (p<0.01) and 38.3% FSH basal values <1 UI/mL (p<0.01). E2 ≤20 pg/mL was observed in 32.72% (p=NS).

Conclusions
Basal LH values are a reliable indicator of the efficacy of GnRHa therapy after 30 months of GnRHa therapy.
ATP synthase deficiency due to m.8528T>C mutation – a novel cause of severe neonatal hyperammonemia requiring hemodialysis
Authors: Žigman Tamara , Šikić Katarina , Petković Ramadža Danijela , Mayr Johannes , Wortmann Saskia , Prokisch Holger , Ninković Dorotea , Dilber Daniel , Šarić Dalibor , Rubić Filip , Galić Slobodan , Slaviček Jasna , Belina Dražen , Fumić Ksenija , Barić Ivo 
Published: November 2020

Abstract

Objectives
Hyperammonemia in a newborn is a serious condition, which requires prompt intervention as it can lead to severe neurological impairment and death if left untreated. The most common causes of hyperammonemia in a newborn are acute liver failure and inherited metabolic disorders. Several mitochondrial disorders have been described as a cause of severe neonatal hyperammonemia.

Case presentation
Here we describe a new case of adenosine-triphosphate (ATP) synthase deficiency due to m.8528T>C mutation as a novel cause of severe neonatal hyperammonemia. So far six patients with this mutation have been described but none of them was reported to need hemodialysis in the first days of life.

Conclusion
This broadens the so far known differential diagnosis of severe neonatal hyperammonemia requiring hemodialysis.
Challenges of following patients with inherited metabolic diseases during the COVID-19 outbreak. A cross-sectional online survey study
Authors: Oge Enver Ece , Hopurcuoglu Duhan , Ahmadzada Seffa , Zubarioglu Tanyel , Aktuglu Zeybek Ayşe Cigdem , Kiykim Ertugrul 
Published: November 2020

Abstract

Objectives
There has been a recent worldwide outbreak of coronavirus disease (COVID-19). Most of the health system capacity has been directed to COVID-19 patients, and routine outpatient clinics have been suspended. Chronic disease patients, such as inherited metabolic disorders (IMD), have had trouble accessing healthcare services.

Methods
An online cross-sectional survey was conducted among patients with IMDs who were present for a follow-up at our clinic to address their problems during pandemic period. Our clinic’s Instagram and Facebook accounts were used to invite the participants. Three reminders were given between May 1, 2020, and May 30, 2020. Survey questions were analyzed using descriptive statics.

Results
A total of 213 patients completed our survey. Incomplete surveys were excluded, and 175 questionnaires were evaluated. Most of patients had a special diet, and 51% of them had some difficulty with their diet. The reported rate of using a special treatment was 38%, and most of these patients (91%) had no problem receiving these special therapies during this time. Parents who were wearing masks while caring for their child were very few (17%), but a vast majority of parents (73.7%) had high handwashing rates. None of the patients had a SARS-COV2 infection until this paper was written.

Conclusion
This is the first study that aims to determine the problems faced by patients with IMD during the COVİD-19 period. Considering that the pandemic will not immediately pass, recognizing the problems faced by patients with chronic diseases and developing solutions would help these patients avoid long-term damage.
Initial review of pregnancy and neonatal outcomes of pregnant women with COVID-19 infection
Authors: Ogamba Ifeoma , Kliss Andrea , Rainville Nicole , Chuang Linus , Panarelli Erin , Petrini Joann , Zilberman Dimitry 
Published: November 2020

Abstract

Objectives
Data regarding the pathogenesis and clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge, however, there’s limited data in regard to maternal and neonatal outcomes. Therefore, we conducted a retrospective analysis of all pregnant women who tested positive for SARS-CoV-2 within Nuvance Health system.

Methods
Data were abstracted from the medical records of each patient and descriptive analysis was performed. Variables included demographics, COVID testing results, symptoms, management, labor course, neonatal information, and complications.

Results
Total of 40 patients were identified. Average age was 29.6 years old, 35% were Hispanic, and approximately one in three patients had comorbidities. Of the patients who had repeated testing, the average number of days between first positive test and negative test was 36.8 days (± 19.9 days). Three out of four women reported symptoms. Of the 40 pregnant women who were positive for SARS-CoV-2, 25 of them delivered. About 84% of the women delivered after 37 weeks. Twelve percent of the women delivered under 33 and 6/7 weeks. Most patients had vaginal deliveries (68%) and the remaining had cesarean deliveries. Neonatal outcomes included: mean 1 and 5 min Apgar scores of 8 and 8.8, respectively and the mean birth weight was 3212 g. Twenty neonates were tested for SARS-CoV-2 and were all found to be negative.

Conclusions
Overall, with routine prenatal care and preventive measures, pregnant patients and neonates in our study had good outcomes. At this time, there appears to be no evidence of vertical transmission.
Experimental evidence supporting the overlapping distribution of core and exempt anaphors: Re-examination of long-distance boundcaki-casinin Korean
Authors: Kim Eun Hee , Yoon James 
Published: November 2020

AbstractThe Korean anaphorcaki-casin, which has been regarded as a local anaphor, has been shown to allow long-distance binding when local binding is not an option (Kim, Ji-Hye & James Yoon. 2009. Long-distance bound local anaphors in Korean: An empirical study of the Korean anaphorcaki-casin.Lingua119. 733–755). In this study, we examined the long-distance binding ofcaki-casinin domains where local binding is possible, and compare it with the long-distance binding ofcaki, the representative long-distance anaphor in Korean. Our investigation revealed that the availability of local binding does not rule out long-distance/exempt binding ofcaki-casin. The results imply that core and exempt binding may not be in complementary distribution, at least in Korean.
Direction and associated motion in Tibeto-Burman
Authors: Genetti Carol , Hildebrandt Kristine , Sims Nathaniel A. , Fawcett Alexia Z. 
Published: November 2020

AbstractThis study analyzes systems of direction and associated motion in 23 languages of the Tibeto-Burman family. Both direction and associated motion can be encoded by a range of grammatical strategies, including affixes, clitics, particles, serial-verb constructions, and auxiliary verbs. While some languages have only associated motion or direction, others have both, either via distinct subsystems, syntactic ambiguity, or context-dependent interpretation. While directional encodings can be interpreted as associated motion in some contexts, the reverse can also be true. Verbal semantics is key to the pragmatic interpretation of examples in context; some types of motion verbs are more compatible with directional interpretations and others with associated motion. In addition, certain types of motion verbs were found to be compatible with different temporal relationships that hold between the activity of the primary verb and the motional component. Finally, the grammatical role of the figure in such constructions depends on both the temporal relationship and the semantics of the verb.
An assessment of language attitudes as a mediator in the stereotypes–L2 motivation linkage
Authors: Nikitina Larisa , Furuoka Fumitaka 
Published: November 2020

Abstract
Applied linguists and language educators have long acknowledged the prominent role that language attitudes play in the process of selecting and learning an additional language. The current study examines a mediating role of language attitudes in the Stereotypes–L2 motivation linkage in the context of learning a foreign language, an area which remains comparatively underexplored. It provides a detailed description of – and rationale for – applying a statistical procedure based on the Baron–Kenny method, which is rarely used in applied linguistics research. The findings indicate that stereotypes and language attitudes had a positive impact on L2 motivation when the former two variables were examined separately in two different analyses. However, when all the three variables were analysed together, language attitudes were found to remain a motivational factor while the stereotypes ceased to be such. This suggests that stereotypes had an indirect effect on L2 motivation through language attitudes. Hence, language attitudes were a mediating variable in the Stereotypes–L2 motivation linkage assessed by the Baron–Kenny method. These findings have some pedagogical implications.
Free nonunitary Rota-Baxter family algebras and typed leaf-spaced decorated planar rooted forests
Authors: Wang Jinwei , Zhang Yuanyuan , Zhu Zhicheng , Chen Dan 
Published: November 2020

Abstract
In this paper, we decorate leaves and edges of planar rooted forests simultaneously and use a part of them to construct free nonunitary Rota-Baxter family algebras. As a corollary, we obtain the construction of free nonunitary Rota-Baxter algebras.
Serum calcium levels correlates with coronary artery disease outcomes
Authors: Wang Mian , Yan Shaodi , Peng Yong , Shi Yu , Tsauo Jiay-Yu , Chen Mao 
Published: November 2020

Abstract

Background
Effect of serum calcium levels on prognosis of patients with coronary artery disease (CAD) is not well evaluated. We aimed to assess the associations of baseline serum calcium levels with both short-term and long-term outcomes in CAD patients.

Methods
This study included 3,109 consecutive patients with angiographically confirmed CAD. Patients were categorized into quartiles according to admission serum calcium. Multivariable regression analysis was used to determine the association of serum calcium with mortality.

Results
Compared to patients in the lowest quartile of serum calcium, patients in upper quartiles were presented with lower all-cause mortality (Hazard ratios [HRs] were −0.636 [95% CI: −0.424 to −0.954], −0.545 [95% CI: −0.351 to −0.846] and −0.641 [95% CI: −0.450 to −0.913] for three upper quartiles versus lowest quartile respectively), cardiovascular mortality (HRs 0.594 [0.368−0.961], 0.261 [0.124–0.551] and 0.407 [0.229–0.725]), and in-hospital mortality (Odd ratios [ORs] 0.391 [0.188–0.812], 0.231 [0.072–0.501] and 0.223 [0.093–0.534]). Consistent associations between serum calcium and long-term mortality were also obtained in subgroup analysis of ACS patients, stable CAD patients and discharged patients.

Conclusions
Serum calcium is inversely associated with CAD and can independently predict both in-hospital and long-term mortality among CAD patients.
Biological properties and therapeutic effects of plant-derived nanovesicles
Authors: Di Gioia Sante , Hossain Md Niamat , Conese Massimo 
Published: November 2020

Abstract
Exosomes-like nanoparticles can be released by a variety of plants and vegetables. The relevance of plant-derived nanovesicles (PDNVs) in interspecies communication is derived from their content in biomolecules (lipids, proteins, and miRNAs), absence of toxicity, easy internalization by mammalian cells, as well as for their anti-inflammatory, immunomodulatory, and regenerative properties. Due to these interesting features, we review here their potential application in the treatment of inflammatory bowel disease (IBD), liver diseases, and cancer as well as their potentiality as drug carriers. Current evidence indicate that PDNVs can improve the disease state at the level of intestine in IBD mouse models by affecting inflammation and promoting prohealing effects. While few reports suggest that anticancer effects can be derived from antiproliferative and immunomodulatory properties of PDNVs, other studies have shown that PDNVs can be used as effective delivery systems for small molecule agents and nucleic acids with therapeutic effects (siRNAs, miRNAs, and DNAs). Finally, since PDNVs are characterized by a proven stability in the gastrointestinal tract, they have been considered as promising delivery systems for natural products contained therein and drugs (including nucleic acids) via the oral route.