bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer
Authors: Robertson John F.R. , Evans Abigail , Henschen Stephan , Kirwan Cliona C. , Jahan Ali , Kenny Laura M. , Dixon J. Michael , Schmid Peter , Kothari Ashutosh , Mohamed Omar , Fasching Peter A. , Cheung Kwok-Leung , Wuerstlein Rachel , Carroll Danielle , Klinowska Teresa , Lindemann Justin P.O. , MacDonald Alexander , Mather Richard , Maudsley Rhiannon , Moschetta Michele , Nikolaou Myria , Roudier Martine P. , Sarvotham Tinnu , Schiavon Gaia , Zhou Diansong , Zhou Li , Harbeck Nadia 
Published: March 2020

AbstractPurpose:Fulvestrant, the first-in-class selective estrogen receptor (ER) degrader (SERD), is clinically effective in patients with ER+ breast cancer, but it has administration and pharmacokinetic limitations. Pharmacodynamic data suggest complete ER degradation is not achieved at fulvestrant's clinically feasible dose. This presurgical study (NCT03236974) compared the pharmacodynamic effects of fulvestrant with AZD9496, a novel, orally bioavailable, nonsteroidal, potent SERD, in treatment-naïve patients with ER+ HER2− primary breast cancer awaiting curative intent surgery.Patients and Methods:Patients were randomized 1:1 to receive AZD9496 250 mg twice daily from day 1 for 5–14 days, or fulvestrant 500 mg on day 1. On-treatment imaging-guided core tumor biopsies were taken between day 5 and 14 and compared with pretreatment diagnostic biopsies. The primary objective was to compare the effects of AZD9496 and fulvestrant on ER expression. Secondary objectives included changes in progesterone receptor (PR) and Ki-67 pharmacokinetic/pharmacodynamic relationships and safety.Results:Forty-six women received treatment (AZD9496 n = 22; fulvestrant n = 24); 35 paired biopsies were evaluable (AZD9496 n = 15; fulvestrant n = 20). The least square mean estimate for ER H-score reduction was 24% after AZD9496 versus 36% after fulvestrant treatment (P = 0.86). AZD9496 also reduced PR H-scores (−33.3%) and Ki-67 levels (−39.9%) from baseline, but was also not superior to fulvestrant (PR: −68.7%, P = 0.97; Ki-67: −75.4%, P = 0.98). No new safety findings were identified.Conclusions:This was the first presurgical study to demonstrate that an oral SERD affects its key biological targets. However, AZD9496 was not superior to fulvestrant at the dose tested.
The Dance of Priests, Matronae, and Philosophers: Aspects of Dance Culture in Rome and the Roman Empire
Authors: Schlapbach Karin 
Published: March 2020

Abstract
The fourteen papers delivered at a conference on Roman dance in June 2019 set about correcting the widespread idea that dance was marginal and held in low esteem in Rome. They elucidated different contexts in which dance was central, especially religion, the theatre, and private entertainments, and further topics included cultural interactions on the Italian peninsula, the diversity of practitioners, the political role of dance, and dance images in poetry. The conference showed not only that further study of Roman dance is necessary, but also that dance is a valuable tool that allows us to think about what we mean when we talk about ‘Roman’ culture.
The Gnostic in Us All: Thinking from the Macrobiotics of Michio Kushi
Authors: Albanese Catherine L. 
Published: March 2020

Abstract
Around 1970 in graduate school, I wrote a paper on the Gospel of Thomas, one of the documents discovered at Nag Hammadi in 1945. The debate over its gnosticizing elements was alive and well, and I weighed in with an argument that its thorough oblivion to history rendered it Gnostic—in the capital-“G” sense. I published a revised version of the paper in an academic journal in 1976. Then in 1986, I began to practice macrobiotics. As I studied the teachings of Michio Kushi, its foremost American teacher, I began to suspect religion. With longtime political interests in world government, Kushi elaborated on a cosmological spiral, with humans descending from a “unique principle” as it divided into yin and yang. Finding balance with yin and yang energies through diet and lifestyle would lead to alignment and peace, even as the earth itself wobbled on its axis through cycles that lasted thousands of years—the earth’s particular location influencing humans for good or ill. Even so, if macrobiotic principles were followed, what lay ahead was “one peaceful world.” Somewhere on the road to one peaceful world, Kushi discovered the Gospel of Thomas. He began to use it regularly in his popular “spiritual” seminars. This article leverages an account of the gnostic (here small-“g”) content of macrobiotics on Michio Kushi’s commentary on the Gospel of Thomas—The Gospel of Peace (1992)—and also on related works. The paper explores the gnosticism of macrobiotic foodways and a peaceful world in terms of American culture, looking for lines of connection and viewing them as encrypted signs—in the twenty-first century still—of the gnostic in us all.
The Passion of the Space Jockey: Alienated Sentience and Endosymbiosis in the World of H. R. Giger
Authors: Wargo Eric 
Published: March 2020

Abstract
The “biomechanoids” of the Swiss painter H. R. Giger (1940–2014) depict the sadomasochistic bondage of humans and machines. Although Giger’s art has commonly been interpreted in psychoanalytic terms as representing some past trauma connected with origins and birth, I argue that it also encodes a distinctly gnostic warning about the trajectory of consciousness in relation to technology, a “fall of spirit into matter” that may lie ahead of our species rather than behind. With the help of the endosymbiosis theory of biologist Lynn Margulis, I decode the dark warning transmission in Giger’s work, especially the iconic “Space Jockey” Giger designed for Ridley Scott’s 1979 blockbuster Alien—a fossilized star pilot fused to its ship. As a vision of the more disturbing possibilities of cyborgs or human-machine symbionts, the Space Jockey contrasts sharply with optimistic dreams of Singularities and “spiritual machines.” It suggests a posthuman future in which distinctly nonspiritual machines find it useful to coopt or exploit spirit (human or otherwise) for their own ends.
A Tropical Cyclone Rapid Intensification Prediction Aid for the Joint Typhoon Warning Center’s Areas of Responsibility
Authors: Knaff John A. , Sampson Charles R. , Strahl Brian R. 
Published: March 2020

Abstract
In late 2017, the Rapid Intensification Prediction Aid (RIPA) was transitioned to operations at the Joint Typhoon Warning Center (JTWC). RIPA probabilistically predicts seven rapid intensification (RI) thresholds over three separate time periods: 25-, 30-, 35-, and 40-kt (1 kt ≈ 0.51 m s−1) increases in 24 h (RI25, RI30, RI35, RI40); 45- and 55-kt increases in 36 h (RI45 and RI55); and 70-kt increases in 48 h (RI70). RIPA’s probabilistic forecasts are also used to produce deterministic forecasts when probabilities exceed 40%, and the latter are included as members of the operational intensity consensus forecast aid. RIPA, initially designed for the western North Pacific, performed remarkably well in all JTWC areas of responsibility (AOR) and is now incorporated into JTWC’s ever improving suite of intensity forecast guidance. Even so, making real-time operational RIPA forecasts exposed some methodological weaknesses such as overprediction of RI for weak/disorganized systems (i.e., systems with maximum winds less than 35 kt), prediction of RI during landfall, input data reliability, and statistical inconsistencies. Modifications to the deterministic forecasts that address these issues are presented, and newly derived and more statistically consistent models are developed using data from all of JTWC’s AORs. The updated RIPA is tested as it would be run in operations and verified using a 2-yr (2018–19) independent sample. The performance from this test indicates the new RIPA—when compared to its predecessor—has improved probabilistic verification statistics, and similar deterministic skill while using fewer predictors to make forecasts.
A Multihazard Assessment of Age-Related Weather Vulnerabilities
Authors: Garner Jonathan M. , Iwasko William C. , Jewel Tyler D. , Charboneau Brad R. , Dodd Alex A. , Zontos Kathleen M. 
Published: March 2020

AbstractWeather fatalities for all age groups were examined for the period 1996–2018 using NOAA Storm Data. Vulnerabilities due to limited mobility that inhibited evacuation from a hazardous environment were observed for the very young and the very old. Those situations included heat- and cold-related hazards, tropical cyclones, and wildfires. Vulnerabilities associated with unrestricted mobility occurred in teenage through middle-aged groups, who were more exposed to fatal outcomes in the surfzone, mountain, winter-driving, and lightning environments. There is evidence that vulnerable members of society who received help from family, neighbors, and their community were more likely to avoid potentially fatal weather events, whereas those who were socially isolated were more likely to succumb. National Weather Service programs, such as Weather-Ready Nation, and other initiatives like the Community Emergency Response Team could potentially aid in reducing weather fatalities by encouraging communities to take a more proactive approach in ensuring physically vulnerable populations like the elderly receive assistance during hazardous weather events. Furthermore, weather-messaging strategies should be flexible enough to target populations who are vulnerable to specific hazards.
Protective effects of Huang-Lian-Jie-Du-Tang against Aβ25–35-induced memory deficits and oxidative stress in rats
Authors: Wu Wenbin , He Xiaojing , Xie Shuling , Li Bin , Chen Jinxin , Qu Yanqin , Li Baiyang , Lei Ming , Liu Xuehui 
Published: March 2020

Objective Huang-Lian-Jie-Du-Tang (HLJDT), a traditional Chinese medicine, improves cognitive ability in rat models of Alzheimer’s disease (AD). The objective of this study was to evaluate the protective effects of HLJDT on learning and memory impairment that are caused by Aβ25–35. Methods Rats were randomly assigned to the following groups: control (water), Aβ25–35, donepezil hydrochloride 1.05 mg/kg, HLJDT 6 g/kg, HLJDT 3 g/kg, and HLJDT 1.5 g/kg and the corresponding drugs were administered for 28 days by oral gavage. HLJDT for the prevention of Aβ25–35-induced injury in rats and the underlying mechanisms were assessed. Aβ25–35 and amyloid precursor protein (APP) levels were measured in the hippocampal specimens. Total superoxide dismutase (T-SOD), glutathione (GSH), and malondialdehyde (MDA) levels in the hippocampus were also measured. The ultrastructure of CA1 hippocampal region was observed using electron microscopy. Results HLJDT treatment ameliorated impaired learning and memory significantly, decreased Aβ25–35, and APP levels in the hippocampus, increased T-SOD and GSH activity and decreased the MDA concentration, and alleviated the nuclear and cytoplasmic abnormalities of the hippocampal CA 1 region that were induced by Aβ25–35 injection. Conclusions HLJDT might decrease hippocampal vulnerability to Aβ25–35, suggesting its potential neuroprotective effect in AD.
High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer
Authors: Ma Liang , Cao Ying , Hu Jianjun , Chu Mingliang 
Published: March 2020

Objective To investigate the effect of the casein kinase 2 interacting protein 1 (CKIP-1) on the apoptosis of the intestinal type of gastric cancer (GC). Methods The levels of CKIP-1 protein and the rates of apoptosis were measured in tissue samples of the intestinal type of GC and human GC cell lines. The rate of apoptosis and the protein levels of B cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), cleaved cysteinyl aspartate specific protease 3 (cleaved caspase-3), cleaved caspase-9, rat sarcoma (Ras), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and phosphorylated extracellular signal-regulated kinase 1 and 2 (p-ERK1/2) were analysed in SGC7901 cells expressing CKIP-1 short hairpin RNA (shRNA; knockdown) and SGC7901 cells overexpressing CKIP-1. Results The levels of CKIP-1 protein were significantly lower in the intestinal type of GC tissues compared with the samples of intestinal metaplasia. Both the levels of CKIP-1 protein and the levels of apoptosis decreased gradually with decreasing cell differentiation in the intestinal type of GC tissue and cell lines; and they were positively correlated. In the CKIP-1 shRNA group, the rate of apoptosis and the levels of Bax, cleaved caspase-3 and cleaved caspase-9 were decreased; and the levels of Bcl-2, Ras and the ratio of p-ERK/ERK were increased, compared with the control group. Opposite results were observed in the CKIP-1 overexpression group. Conclusion High levels of CKIP-1 protein may promote apoptosis in the intestinal type of GC, possibly via the downregulation of the Ras/ERK signalling pathway.
Hyperamylasemia as an early predictor of mortality in patients with acute paraquat poisoning
Authors: Huang Changbao , Bai Lina , Xue Xiang , Peng Liangfei , Jiang Jinghan , Zhang Xigang 
Published: March 2020

Objective This study aimed to evaluate the relationship between elevated serum amylase levels and the prognosis of paraquat poisoning. Methods Patients were categorized into the elevated and non-elevated serum amylase groups according to serum amylase levels. Demographics, mortality, risk factors of elevated serum amylase levels, and injury to the pancreas were analyzed. Results A total of 457 patients were enrolled in this study and the overall mortality rate was 51.9%. Patients in the elevated group had worse indices than those in the non-elevated group. Kaplan–Meier survival analysis showed that the mortality rate in the elevated group was significantly higher than that in the non-elevated group (hazard ratio: 10.65, 95% confidence interval [CI]: 7.55–15.02). Multivariate Cox proportional hazards analysis showed that elevated serum amylase levels were related to mortality (hazard ratio: 2.066, 95% CI: 1.239–3.444). The receiver operating characteristic curve showed that the area under the curve was 0.724 (95% CI: 0.666–0.783) for serum amylase levels with 70.4% sensitivity and 74.0% specificity. Conclusion Elevated serum amylase levels are observed in PQ poisoning. This elevation might be one of the most accurate early prognostic factors for predicting severity and mortality.
Timing of Return to Batting Milestones After Ulnar Collateral Ligament Reconstruction in Professional Baseball Players
Authors: Erickson Brandon J. , Chalmers Peter N. , D’Angelo John , Ma Kevin , Sheridan Scott , Schickendantz Mark , Romeo Anthony A. 
Published: March 2020

Background: Ulnar collateral ligament reconstruction (UCLR) is a common procedure in professional baseball position players. Timing of return to hitting after UCLR is unknown. Purpose/Hypothesis: The purpose was to determine the time to return to batting milestones after UCLR as well as the effect of UCLR upon batting performance in professional baseball players. The hypothesis was that position players would return to batting in an in-season game before fielding in an in-season game, and hitting performance would remain unchanged after UCLR. Study Design: Cohort study; Level of evidence, 3. Methods: All professional position players who underwent UCLR between 2010 and 2018 were included. Time to batting milestones after UCLR was analyzed. Batting performance before and after UCLR was compared and analyzed. Results: Overall, 141 UCLRs (96% performed on the dominant arm) in 137 position players were included (86% Minor League players). Four players underwent revision, all within 1 year of the primary UCLR. With regard to position, catchers and shortstops were overrepresented. With regard to batting side, 57% batted from the right and 12% batted as switch-hitters. Of the surgeries, 76% were on the trail/back arm. While 91% of players returned to some form of throwing, there was a progressive gradual decline as the rehabilitation process progressed, as only 77% were able to return to hitting in a real game and 75% were able to return to fielding in a real game. The first dry swing occurred at 150 ± 49 days after surgery, the first batting practice occurred at 195 ± 58 days after surgery, the first hitting in a real game occurred at 323 ± 92 days after surgery, and the first fielding in a real game occurred at 343 ± 98 days after surgery. However, players generally saw a decrease in their utilization, with fewer at bats ( P < .001) translating into fewer hits ( P < .001) and runs ( P < .001). Conclusion: Professional position players begin swinging at 150 days (approximately 5 months) after UCLR, while they do not hit in batting practice until 195 days (approximately 6.5 months) and do not hit in a real game until 323 days (approximately 10.7 months) after UCLR. Players see a decrease in hitting utilization after UCLR. On average, players hit in a real game 20 days before fielding in a real game.
An Evaluation of the Content of Canadian and American Nuclear Medicine Fellowship Websites
Authors: Hamid Saira , Gibney Brian , Niu Bonnie , Phord-Toy Rachel , Murray Nicolas , Vijayasarathi Arvind , Nicolaou Savvas , Khosa Faisal 
Published: March 2020

Background: Radiology trainees frequently use the Internet to research potential fellowship programs across all subspecialties. For a field like nuclear medicine, which has multiple training pathways, program websites can be an essential resource for potential applicants. This study aimed to analyze the online content of Canadian and American Nuclear Medicine fellowship websites. Materials and Methods: The content of all active Canadian and American Nuclear Medicine fellowship websites was evaluated using 26 criteria in the following subdivisions: application, recruitment, education, research, clinical work, and incentives. Fellowships without websites were excluded from the study. Scores were summed per program and compared by geographic region and ranking. Results: A total of 42 active Canadian and American Nuclear Medicine fellowship programs were identified, of which 39 fellowships had dedicated fellowship websites available for the analysis. On average, fellowship websites contained 34.4% (9 ± 3.3) of the 26 criteria. Programs did not score differently on the criteria by geographical distribution ( P = .08) nor by ranking ( P = .18). Conclusion: Most Canadian and American Nuclear Medicine fellowship websites are lacking content relevant to prospective fellows. Addressing inadequacies in online content may support programs to inform and recruit residents into fellowship programs.
Urgent-start dialysis: Comparison of complications and outcomes between peritoneal dialysis and haemodialysis
Authors: Dias Dayana Bitencourt , Mendes Marcela Lara , Caramori Jacqueline Teixeira , Falbo dos Reis Pâmela , Ponce Daniela 
Published: March 2020

Background: Few studies have evaluated the viability and outcomes between peritoneal dialysis (PD) and haemodialysis (HD) in urgent-start renal replacement therapy (RRT). This study aimed to compare infectious and mechanical complications related to urgent-start PD and HD. Secondary outcomes were to identify risk factors for complications and mortality related to urgent-start dialysis. Methods: A quasi-experimental study with incident patients receiving PD and HD in a Brazilian university hospital, between July 2014 and December 2017. Subjects included individuals with final-stage chronic kidney disease who required immediate RRT, that is, HD through central venous catheter or PD in which the catheter was implanted by a nephrologist and utilized for 72 h, without previous training. Patients with PD were subjected, initially, to high-volume PD for metabolic compensation. After hospital discharge, they remained in intermittent PD in the dialysis unit until training was completed. Mechanical and infectious complications were compared, as well as the recovery of renal function and survival. Results: In total, 93 patients were included in PD and 91 in HD. PD and HD groups were similar regarding age (58 ± 17 vs. 60 ± 15 years; p = 0.49), frequency of diabetes mellitus (37.6% vs. 50.5%; p = 0.10), other comorbidities (74.1% vs. 71.4%; p = 0.67) and biochemical parameters at the beginning of RRT, that is, creatinine (9.1 ± 4.1 vs. 8.0 ± 2.8; p = 0.09), serum albumin (3.1 ± 0.6 vs. 3.3 ± 0.6; p = 0.06) and haemoglobin (9.5 ± 1.8 vs. 9.8 ± 2.0; p = 0.44). After a minimum follow-up period of 180 days and a maximum follow-up period of 2 years, there was no difference regarding mechanical complications (24.7% vs. 37.4%; p = 0.06) or bacteraemia (15.0% vs. 24.0%; p = 0.11); however, there was a difference regarding infection of the exit site (25.8% vs. 39.5%; p = 0.04) and diuresis maintenance [700 (0–1500) vs. 0 (0–500); p < 0.001], with better results in the PD group. There was better phosphorus control at 180 days in the PD group (62.4% vs. 41.8%; p = 0.008), with a lower requirement for phosphate binder usage (28% vs. 55%; p < 0.001), erythropoietin (18.3% vs. 49.5%; p < 0.001) and anti-hypertensives (11.8% vs. 30.8%; p = 0.003). Time to death was similar between groups. In the multivariate analysis, PD was a predictor of renal function recovery [odds ratio: 3.95 (1.01–15.4)]. Conclusion: PD is a viable and safe alternative to HD in a scenario of urgent-start RRT with complication rates and outcomes similar to those of HD, highlighting the results regarding renal function recovery.
Catastrophic antiphospholipid syndrome following the introduction of rivaroxaban
Authors: Stammler Romain , Legendre Paul , Cacoub Patrice , Blanche Philippe , Piette Jean -Charles , Costedoat -Chalumeau Nathalie 
Published: March 2020

Summary Catastrophic antiphospholipid syndrome is the most severe complication of antiphospholipid syndrome. Vitamin K antagonists are the reference treatment for preventing relapsing thrombotic complications in patients with antiphospholipid syndrome. Direct oral anticoagulants are nonetheless sometimes used in this setting. We report two cases of women who were triple-positive for antiphospholipid antibodies and developed catastrophic antiphospholipid syndrome in the week after the introduction of rivaroxaban. The first patient, who had had a previous thrombotic event, had multiorgan failure 3 days after vitamin K antagonists was replaced by rivaroxaban, and the second developed a similar clinical presentation 7 days after introduction of the same treatment. Both catastrophic antiphospholipid syndrome episodes were successfully treated with heparin followed by vitamin K antagonists, corticosteroids, and plasmapheresis. These two cases highlight for the inefficacy of rivaroxaban preventing severe thrombotic events such as catastrophic antiphospholipid syndrome and thus provide further support for recommendations that vitamin K antagonists must remain the reference anticoagulant in patients with triple-positive antiphospholipid antibodies.