bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Opioid Use After Total Hip Arthroplasty: A Comprehensive Analysis of a Mandatory Prescription Drug Monitoring Program
Authors: Tan Timothy L. , Rondon Alexander J. , Wilt Zachary , Wang William L. , Kalbian Irene , Foltz Carol , Beredjiklian Pedro K. , Arnold William V. 
Published: February 2020

Introduction:
Opioids remain the most prescribed medication after total hip arthroplasty (THA) despite the potential for abuse and adverse effects. Given the high rates of opioid abuse and potential adverse effects, the reporting of controlled substances is now mandatory in many statewide databases. This study aimed to use a mandatory statewide database to analyze opioid prescription patterns in postoperative THA patients and identify independent risk factors for those patients who need a second prescription and/or require prolonged use (>6 months).

Methods:
We retrospectively reviewed a consecutive series of 619 primary THAs. Demographic and comorbidity information were collected for all patients. Narcotic prescription data (converted to morphine milligram equivalents) as well as prescription data for sedatives, benzodiazepines, and stimulants were collected from the State's Controlled Substance Monitoring websites 6 months before and 9 months after the index procedure. Bivariate and multivariate analyses were done for second prescription and continued use.

Results:
Of the 619 patients who underwent THA, 34.9% (216/619) used preoperative opioids, 36.2% (224/619) filled a second opioid prescription, and 10.5% (65/619) had continued use past 6 months. Patients with preoperative opioids were at an approximately 4-fold increased odds of requiring a second script and 12 times odds of continued opioid use. In the multivariate analysis, independent risk factors for requiring a second prescription, in descending order of magnitude, included the use of any sedative or sleep aid prescription and preoperative narcotic use. Independent risk factors for continued narcotic use longer than 6 months after THA included preoperative narcotic use and increased length of stay.

Discussion:
Several risk factors and their relative weight have been identified for continued narcotic consumption after THA. It is important for surgeons to consider these predisposing factors preoperatively during the informed consent process and for managing postoperative pain expectations.
Matriks Pengontrol Pelepasan Urea Berbasis Karagenan: Pengaruh Konsentrasi Glutaraldehid
Authors: Distantina Sperisa , Kaavessina Mujtahid , Fadilah Fadilah 
Published: February 2020

Abstrak. Pada penelitian ini, matrik hidrogel berbasis karagenan dibuat dan diaplikasikan untuk mengontrol pelepasan urea. Tujuan penelitian ini adalah mempelajari pengaruh konsentrasi glutaraldehid terhadap kecepatan pelepasan urea dan menyusun model kecepatan pelepasan urea. Film karagenan dimodifikasi secara kimiawi menggunakan ikatan silang atau crosslinking dengan glutaraldehid. Larutan karagenan 7 g/100 mL dicetak menjadi lembaran dan kemudian dikeringkan sehingga diperoleh lapisan film. Film direndam dalam larutan glutaraldehid dengan konsentrasi tertentu selama 2 menit dan dilanjutkan dipanaskan pada suhu 110oC selama 20 menit. Film yang dihasilkan dicuci dengan etanol dan dikeringkan. Pengisian urea ke dalam matrik film menggunakan metode difusi. Film kering direndam dalam larutan urea 0,074 g/mL selama satu jam dan selanjutnya dikeringkan. Kecepatan pelepasan urea dari film ke dalam media air dievaluasi berdasarkan data konsentrasi urea dalam cairan sebagai fungsi waktu. Berdasarkan hasil penelitian didapatkan bahwa semakin besar konsentrasi glutaraldehid (1-5%) menyebabkan urea yang tersimpan di dalam film semakin rendah. Model matematika yang diusulkan dapat mewakili peristiwa pelepasan urea dari film. Film berbasis karagenan yang dihasilkan berpotensi sebagai matrik pengontrol pelepasan urea. Kata kunci: crosslinking, glutaraldehid, hidrogel, karagenan, urea. Abstract. Controlled Release Matrices of Urea from Carrageenan: Effect of Glutaraldehyde Concentration. In this study, carrageenan-based hydrogel matrices were prepared and applied for urea controlled release. The aim of this work was to study the effect of glutaraldehyde concentration on the rate of urea release in water. Carrageenan films were chemically modified by crosslinking with glutaraldehyde. The films were prepared by casting the aqueous carrageenan 7 g/100 mL and then followed by drying. The films obtained were immersed in certain glutaraldehyde concentration for 2 min and then heated in the oven at 110oC for 20 min. The crosslinked films were washed using ethanol and then air-dried until the weight is constant. The dried films were immersed in a urea solution (0.074g/ml) for 1 hr and then dried. The rate of urea release was determined by measuring the urea concentration in water as a function of time of release. Results showed that higher glutaraldehyde concentration (1–5%) produced films with less urea content. The proposed mathematic model of urea release from the film can represent the rate of urea release. The prepared carrageenan-based film has the potential for controlling of urea release. Keywords: carrageenan, crosslinking, glutaraldehyde, hydrogel, urea. Graphical Abstract
Quand la perception des employeurs à l’égard des personnes immigrantes influence leurs pratiques de gestion de la diversité
Authors: Beaudry Catherine , Gagnon Mélanie , Deschênes Andrée-Anne 
Published: February 2020

Au Québec comme ailleurs dans le monde, certains groupes demeurent sous-représentés en emploi. Les personnes immigrantes récentes (PIR) font partie de ces groupes qui voient leur participation au marché du travail entravée par différentes barrières, alors qu’ils présentent un taux de chômage nettement plus élevé que les natifs.Cet article s’intéresse au lien entre les perceptions des employeurs à l’égard des PIR et les pratiques de gestion de la diversité contribuant à leur rétention. La démarche méthodologique s’appuie sur un devis exploratoire mixte, alors que 2 376 employeurs ont répondu à un questionnaire et que 87 ont participé à des groupes de discussion. Ces employeurs sont représentés par de propriétaires d’entreprise, des dirigeants, des gestionnaires, des directeurs ou des professionnels en gestion des ressources humaines de divers secteurs d’activité et d’entreprises de taille variée.Les résultats indiquent d’abord un relation positive significative entre les expériences d’embauches des PIR et les perceptions que les employeurs entretiennent à leur égard (r = 0,532,p< 0,01). En groupes de discussion, les participants évoquent l’évolution des perceptions selon la nature de l’expérience d’embauche, positive ou négative. Les résultats témoignent également de relations positives et significatives entre les perceptions et les pratiques de rétention, présentant des coefficients de corrélations de l’ordre de 0,185 à 0,390 (p< 0,01). La phase qualitative permet de constater que lorsque les employeurs perçoivent que les PIR concourent à la performance organisationnelle, ils sont davantage enclins à mettre en place des mesures de gestion de la diversité.Les bénéfices escomptés par les employeurs au regard de l’embauche des PIR modulent leur volonté à mettre en oeuvre diverses mesures de rétention. La gestion réactive de la diversité est alors constatée, quoique certains employeurs procèdent à une réflexion s’orientant vers la proactivité.
Workers’ Knowledge and Views on Interaction with Health and Safety Representatives: An Exploratory Qualitative Study
Authors: Ollé-Espluga Laia , Vergara-Duarte Montse , Menéndez-Fuster María , Benach Joan , Vázquez María-Luisa 
Published: February 2020

The action of health and safety representatives (HSRs) has proven beneficial for workers’ occupational health, but a number of determining factors can diminish HSRs’ effectiveness. One understudied factor shaping HSRs’ effectiveness is the interaction that exists between workers and HSRs, that is, the relationship that workers and their representatives establish with each other throughout a wide range of processes.
In this paper, we explore the workers’ knowledge and opinions of their interaction with HSRs and its determinants. We undertook a qualitative exploratory and descriptive-interpretative study by means of 22 semi-structured interviews with a theoretical sample of workers from Barcelona and Girona (Spain).
Results show a vast unawareness of HSRs’ existence and functions among workers; only the few workers who know the HSRs personally describe interaction processes with them, mainly concerning hazard identification. Some of the workers mentioned processes of interaction with unions regarding health and safety at work. These processes consist mainly in raising issues with union representatives and, in a more limited way, in associating with occupational health mobilizations and participating in decision-making processes. Determining factors of the interaction between workers and -health and safety or union- representatives emerge strongly in relation to representatives and workers and, in a more diluted way, with regard to the context or the firm.
The study contributes to the research concerning the building of relations of representativeness as a way to better understand (and represent) workers’ needs and provides strategic insight for collective representation bodies to regain their legitimacy.
Job Insecurity and Abusive Supervision
Authors: Mao Hsiao-Yen , Chien Yuan-Yu , Hsieh An-Tien 
Published: February 2020

Because of increased market uncertainty, employers today often do not guarantee job security and employees increasingly perceive such a state, often with trepidation. Employees who have relatively insecure jobs tend to feel mistreated by their managers. This study examines the relationship between the work places where jobs are mostly insecure and employee perception of abusive supervision, and the moderating role of a relational mechanism of perceived social worth at work.
The conservation of resources (COR) perspective is used to guide analysis. This perspective provides competing rationales for employee acquisition/preservation of resources and ensuing abusive supervision. In a two-wave panel survey, 271 full-time employees with various occupations completed two questionnaires. Results indicate that job insecurity is positively associated with abusive supervision. This association is stronger for employees who perceive higher social worth at work.
There is limited research investigating how managerial/leadership effectiveness varies in workplaces where job’s are insecure. Moreover, a relational mechanism of social worth has rarely been used to examine the phenomenon of job insecurity. Although literature shows employees’ perception of job insecurity leads them to increase work input/effort to make themselves more valuable and worthy of remaining in the organization, this does not mean that they will be more likely to notions such as management prerogative on their employer’s authority. Ironically, leadership, in particular, tends to be undermined when jobs are insecure as our findings show that insecure subordinates tend to perceive themselves experiencing supervisory abuse. To address this malaise, practical implications for organizations, supervisors, and subordinates are proposed and complementary practices are discussed to differentiate high social-worth employees from others.
Courir après le bien commun
Authors: Soldani Jérôme 
Published: February 2020

Au lendemain de la Seconde Guerre mondiale, le Parti nationalistechinois (Kuomintang) prend le contrôle de Taïwan avant des’y replier durablement à partir de 1949. Sonadministration se glisse dans les structures établies par legouvernement colonial japonais (1895–1945) et les institutionstelles que l’école s’inscrivent désormaisdans le service public de la République de Chine. Les pratiquessportives sont inscrites dans l’éducation publique et sontenvisagées comme des leviers de l’intégration despopulations locales au dispositif colonial, principalement cellesd’origine austronésienne. Les performances des jeunesathlètes austronésiens, notamment dans les tournoisinternationaux, sont autant de pierres apportées àl’édification d’un État pluriethniquedominé par la majorité chinoise han. Dans cettecontribution, il sera question d’observer et d’analysercomment les Austronésiens formosans, qui disposent depuis 1994du statut d’Autochtones, détournent et seréapproprient les pratiques sportives dans le cadre du servicepublic de l’éducation — sport etéducation étant ici compris comme faisant partie du biencommun — pour négocier leur position au sein del’État taïwanais et faire face aux politiquesassimilatrices du pouvoir central. Comment se sont historiquementstructurés des rapports de force et de domination entre lespopulations austronésiennes de Taïwan et lesautorités centrales, notamment à travers le sport ?En quoi les stéréotypes, moraux et physiques, quicaractérisent négativement les athlètesautochtones sont-ils devenus un levier de leurs revendications ?En quoi la réappropriation des sports par les Autochtonesest-elle une forme d’accession au bien commun et un vecteur de lareproduction des sociétés austronésiennes au seind’un espace public dans lequel elles sontgénéralement marginalisées ?
Osteopathic Treatment Approach to Psychoemotional Trauma by Means of Bifocal Integration
Authors: Liem Torsten , Neuhuber Winfried 
Published: February 2020

AbstractTraumatic psychoemotional experiences often manifest in hypersympathetic states of excitement or in immobilization and withdrawal behaviors. A person with this kind of traumatic background may present with an autonomic response consistently maintained in the defensive state, which over time becomes a stressor. In this article, the authors discuss an osteopathic approach to psychoemotional trauma by means of bifocal integration, with an emphasis on promoting a relaxed body and mind by actively involving the patient in the healing process. They briefly discuss the role of mind-body therapies in treatment, considering the popular polyvagal theory and other neuropsychophysiological frameworks. The authors also focus on clinical practice, introducing the reader to the different elements of the osteopathic treatment, including the acknowledgement and integration of top-down and bottom-up dynamics in diagnosis and therapy.
SERPINA1gene identified in RNA-Seq showed strong association with milk protein concentration in Chinese Holstein cows
Authors: Li Cong , Cai Wentao , Liu Shuli , Zhou Chenghao , Yin Hongwei , Sun Dongxiao , Zhang Shengli 
Published: February 2020

The detection of candidate genes and mutations associated with phenotypic traits is important for livestock animals. A previous RNA-Seq study revealed thatSERPINA1gene was a functional candidate that may affect milk protein concentration in dairy cows. To further confirm the genetic effect ofSERPINA1on milk protein traits, genetic polymorphisms were identified and genotype-phenotype associations were performed in a large Chinese Holstein cattle population. The entire coding region and the 5′-regulatory region (5′-UTR) ofSERPINA1was sequenced using pooled DNA of 17 unrelated sires. Association studies for five milk production traits were performed using a mixed model with a population encompassing 1,027 Chinese Holstein cows. A total of four SNPs were identified inSERPINA1, among whichrs210222822andrs41257068presented in exons,rs207601878presented in an intron, andrs208607693was in the 5′-UTR. Analyses of pairwise D′ measures of linkage disequilibrium (LD) showed strong linkage among these four SNPs (D′ = 0.99–1.00), and a 9 Kb haplotype block involving three main haplotypes with GTGT, CCCC and CCGT was inferred. An association study revealed that all four single SNPs and their haplotypes had significant genetic effects on milk protein percentage, milk protein yield and milk yield (P = 0.0458 − < 0.0001). The phenotypic variance ratio for all 11 significant SNP-trait pairs ranged from 1.01% to 7.54%. The candidate gene ofSERPINA1revealed by our previous RNA-Seq study was confirmed to have pronounced effect on milk protein traits on a genome level. Two SNPs (rs208607693andrs210222822) presented phenotypic variances of approximately 7% and may be used as key or potential markers to assist selection for new lines of cows with high protein concentration.
lncRNA–mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis
Authors: Lin Min , Mao Zhu-Jun 
Published: February 2020

Background
Radix Astragali (Astragalus membranaceus var. mongholicus (Bunge)) and Coptis chinensis (Coptis chinensis var. angustiloba) are two commonly prescribed traditional Chinese herbs for diabetes. Astragalus Polysaccharide (AP) and Berberine (BBR) are active ingredients of these two herbs respectively and they are scientifically proved to have immunomodulatory and anti-inflammatory effects. They are also known for their antidiabetic potential by ameliorating insulin resistance (IR). AP and BBR have shown different advantages in treating diabetes according to previous reports. However, very few studies focus on the combined activities of the two potential antidiabetic ingredients. In this study, we discovered that reactive oxygen species (ROS) accumulated in IR-hepG2 cells and APBBR can decrease ROS level in model group significantly. We conjectured that APBBR can ameliorate IR in hepG2 cells by decreasing ROS level. In order to verify this hypothesis, we obtained phenotype and transcriptome information of IR-HepG2 cells and explore the underlying mechanism of the combination of AP and BBR(APBBR) activity on the relationship between ROS change in IR at whole-transcriptome level, so as to shed new light to efficacy and application of APBBR in treating diabetes.

Methods
The IR cell model was established with high-level insulin intervention. Glucose content, HepG2 cell viability as well as ROS level was detected to study the effect of IR-hepG2 cell phenotype. Unbiased genome-wide RNA sequencing was used to investigate alterations in experimental groups. Then, GO and KEGG functional enrichment was performed to explore the function and pathway of target genes. Venn analysis found out the differentially expressed lncRNAs that had close relationship with IR and ROS. Finally, we screened out candidate lncRNAs and these target genes to construct interaction network of differentiated lncRNA–miRNA–mRNA by according to the principle of competitive endogenous RNA (ceRNA).

Results
The biochemical experiments showed that APBBR administration could improve the proliferation activity of IR-HepG2 cells and decrease ROS level in model cells. The GO and KEGG functional enrichment analyses demonstrated several mRNAs remarkably enriched in biological processes and signaling pathways related to ROS production and IR progression. Interaction network suggest that APBBR ameliorates IR in HepG2 cells by regulating the expression of multiple genes and activating relevant signaling pathway to decrease ROS level. Thus, we demonstrated that APBBR ameliorated IR in hepG2 cells via the ROS-dependent pathway.
Trials on In vitro Propagation and Using Natural Additives for Myrtus communis L. Plant
Authors: Ghatas Y. A. A. 
Published: February 2020

Explant types, anti-oxidant pre-treatments, organic additives, natural additives, vitamins mix strengths, cytokinin types and concentrations, different medium strengths, GA3 concentrations, auxin types and concentrations were studied during the period from 2017 to 2018 to establish a protocol for in vitro propagation of Myrtle. It was found that culturing of pre-treated shoot tips with anti-oxidant solution (A.O.S) on modified Murashige and Skoog (MS), or Murashige and Skoog medium supplemented with PVP as anti-oxidants induced the best results in reducing free phenolic compounds and enhancing explant development parameters. Also, adding combination of tryptophan, adenine sulphate and coconut water as organic additives maximized survival percentage and improved explant development. In the same time, adding combination of coconut water at 5% plus Banana pulp plus Papaya extract at 50 g/L of were helpful in maximizing number of shoots/plant, shoot length and greening parameters. Also duplicating the dose of vitamin mix of Gamborg medium improved explants development and survival (%) of explant. Meanwhile, using of 1.0 mg/ L BAP increased proliferation. Meanwhile, addition of 2.0 mg/ L GA3 to half strength medium maximized shoot length. Moreover, the addition of 2.0 mg/L IBA to the culture medium induced the highest number of roots/plant.
A Study of Parasitic Copepod Infesting Two Freshwater Fish Populations (Cyprinus carpio and Abramis brama) from Beni-Haroun Dam (Mila) North-East of Algeria
Authors: Berrouk Houda , Tolba Mounia , Touarfia Moundji , Boualleg Chahinez 
Published: February 2020

Copepods are one of the main fish ectoparasites, commonly known among the parasitism world, due either to their special adaptive capacity or to induce stress in aquatic organisms, as well as the parasitism result is overall a physiological rate affecting the survival of host. This study was, therefore, aimed to investigate the ectoparasite copepods, infesting 277 fishes including 135 of Cyprinus carpio (Linnaeus, 1758) and 142 of Abramis brama (Linnaeus,1758), collected from Beni-Haroun dam (Mila, northeast Algeria). The fishes were subjected to some morphometric measurements and gill dissections and the harvested parasites were afterwards stored and identified. The parasitic indices were determined to examine the effect of size, sex, season and microhabitat on the parasitic infestation by using χ2 test. The gill examination of individuals of the two host fishes led to harvest 135 copepods, including 127 individuals from Cyprinus carpio belonging to five species (Ergasilus sieboldi, Ergasilus briani, Neoergasilus japonicus, Neoergasilus longispinosis and Lernaea cyprinacae) and 8 individuals from Abramis brama belonging to the two species: Ergasilus sieboldi and Ergasilus briani, and hence Cyprinus carpio is the most infested species than Abramis brama. This study also revealed that the parasitic index values were high in C. carpio (P=53.00%; A=3.7; I=6.93) compared to A. brama (P=12,0.5%, A=0.12, I=1.00) during autumn, since no effect on infestation was noticed during winter. The statistical analysis has revealed the effect of season on parasitic copepod infestation in the two fish species (χ2Obs =30,959 > χ20.05 = 7,815, ddl =3), Since there was no effect due to the microhabitat and sex.