bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking parental mediation practices to adolescents’ problematic online screen use: A systematic literature review
Authors: Nielsen Philip , Favez Nicolas , Liddle Howard , Rigter Henk 
Published: December 2019

Background and aims
To remedy problematic Internet use (PIU) and problematic online gaming (POG) in adolescents, much is expected from efforts by parents to help youths to contain their screen use. Such parental mediation can include (a) refraining from acting, (b) co-viewing or co-gaming with the teen, (c) active mediation, and (d) restrictive mediation. We evaluated if parental mediation practices are linked to PIU and POG in adolescents.

Methods
For a systematic literature review, we searched for publications presenting survey data and relating parental mediation practices to levels of PIU and/or POG in adolescents. The review’s selection criteria were met by 18 PIU and 9 POG publications, reporting on 81.002 and 12.915 adolescents, respectively. We extracted data on gaming problems, mediation interventions, study design features, and sample characteristics.

Results
No type of parental mediation was consistently associated with lower or elevated problematic screen use rates in the adolescents. Refraining from parental mediation tended to aggravate screen use problems, whereas active mediation (talking to the teen) may mitigate such problems in PIU, but less clearly in POG. The link of restrictive mediation with problematic screen use varied from positive to negative, possibly depending on type of restriction. In both PIU and POG, family cohesion was related to lower rates of the problem behavior concerned and family conflict to higher rates.

Discussion and conclusions
Parental mediation practices may affect problematic screen use rates for better or worse. However, research of higher quality, including observations of parent-teen interactions, is needed to confirm the trends noted and advance the critical issue of the possible association between PIU, POG, and family interactions.
THE INTERPRETATION OF “FIRE” IN INDONESIAN AND ENGLISH PROVERBS: A COGNITIVE SEMANTICS ANALYSIS
Authors: Aqromi Nur Lailatul 
Published: December 2019

<p align="justify">It is believed that proverbs from each nation reflect the nation’s thoughts and characters. Based on the relationship between human conceptualization and language reflected in proverbs, then this study attempts to examine Indonesian proverb and English proverb by using a cognitive semantics approach. The data are taken from Indonesian proverb and English proverb containing <em>api</em> or “fire” word as it is one of the natural symbols of human life. Furthermore, based on the comparison of 7 Indonesian proverbs and 8 English proverbs containing <em>api or “</em>fire” word, the results of the study show that there are two categories created: first, proverbs in the same form and meaning including the risk mapping, anger and work; second, proverbs from the same form but different meanings. </p>
Os materiais didáticos veiculados pelo Manual do Professor Primário do Paraná para o ensino da matemática na década de 1960
Authors: Rodrigues da Costa Reginaldo , Alexandre do Amaral Wagner 
Published: December 2019

O presente texto trata dos materiais didáticos para o ensino da matemática indicados pelo Manual do Professor Primário do Paraná. O questionamento que orientou este estudo foi: Que materiais didáticos eram indicados pelo Manual do Professor Primário do Paraná para o ensino da matemática nas escolas do estado na década de 1960? Amparado pela perspectiva da história cultural e dos conceitos de representação e apropriação o texto apresenta as orientações e os materiais didáticos indicados para o ensino da matemática na época e confrontados com referenciais como: Backheuser (1946), Costa (2016), Pinto (2016) e Pinheiro (2013). Foi possível identificar que os recursos e materiais didáticos expressavam uma concepção de ensino ativo e intuitivo, ou seja, o Manual do Professor Primário do Paraná seguia uma tendência que possibilitava ao aluno o contato com objetos que pudessem expressar conceitos e fatos matemáticos.
The Effectiveness of Design Thinking Training in Increasing Intention of Innovative Behavior and Creativity
Authors: Hidajat Hajan 
Published: December 2019

<p>This study aims to empirically examine the effectiveness of design thinking training to improve the intention to behave innovatively and creatively. The research method used to carry out this research is the Quasi Experiment Method. The results of hypothesis testing using t-test showed that there was no significant difference in creativity scores between before and after the training treatment. This shows that Design Thinking training is not effective in increasing creativity. However, the two alternative hypotheses were tested using t-test showed that there were significant differences scores of innovative behavior intention before and after treatment of Design Thinking. This shows that Design Thinking training is effective in increasing the intention to behave innovative. This research is expected to contribute studies on the effectiveness of the Design Thinking training method and produce a training module that can be used in the entrepreneurial learning process. Based on the results of this study, Design Thinking training can be used as a method to encourage innovative behavior.</p><p> </p><p>intensi berperilaku inovatif, kreativitas, <em>design thinking</em>, pelatihan <em>design thinking </em></p>
Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species
Authors: Zhou Ting , Luo Xiujun , Zhang Chengchao , Xu Xinyun , Yu Chunna , Jiang Zhifang , Zhang Lei , Yuan Huwei , Zheng Bingsong , Pi Erxu , Shen Chenjia 
Published: December 2019

Abstract
Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids and other active ingredients can vary greatly among Taxus species. In our study, the metabolomes of three Taxus species have been investigated.Results A total of 2,246 metabolites assigned to various primary and secondary metabolic pathways were identified using an untargeted approach. Analysis of differentially accumulated metabolites identified 358 T. media -, 220 T. cuspidata -, and 169 T. mairei -specific accumulated metabolites, respectively. By searching the metabolite pool, 7 MEP pathway precursors, 11 intermediates, side chain products and derivatives of paclitaxel, and paclitaxel itself were detected. Most precursors, initiated intermediates were highly accumulated in T. mairei , and most intermediate products approaching the end point of taxol biosynthesis pathway were primarily accumulated in T. cuspidata and T. media . Our data suggested that there were higher-efficiency pathways to paclitaxel in T. cuspidata and T. media compared with in T. mairei . As an important class of active ingredients in Taxus trees, a majority of flavonoids were predominantly accumulated in T. mairei rather than T. media and T. cuspidata . The variations in several selected taxoids and flavonoids were confirmed using a targeted approach.Conclusions Systematic correlativity analysis identifies a number of metabolites associated with paclitaxel biosynthesis, suggesting a potential negative correlation between flavonoid metabolism and taxoid accumulation. Investigation of the variations in taxoids and other active ingredients will provide us with a deeper understanding of the interspecific differential accumulation of taxoids and an opportunity to accelerate the highest-yielding species breeding and resource utilization.
Lessons learned from engaging communities for Ebola vaccine trials in Sierra Leone: Reciprocity, relatability, relationships and respect (The Four R’s)
Authors: Dada Sara , McKay Gillian , Mateus Ana L. , Lees Shelley 
Published: December 2019

Abstract
Background

Building trust and engaging the community are important for biomedical trials. This was core to the set up and delivery of the EBOVAC-Salone and PREVAC Ebola vaccine trials in Sierra Leone during and following the 2014-2016 West African Ebola epidemic. Local community liaison teams (CLT) engaged with the community through public meetings, radio chat shows, and other activities, while a social science team (SST) assessed community members’ and participants’ perceptions and regularly updated the clinical team to adapt procedures to improve the acceptability and compliance of the trial. The objective of this study was to examine the community engagement (CE) program in these trials and to identify potential barriers and facilitators.Methods

Fifteen CLT and SST members participated in in-depth interviews and 23 community members attended three focus groups to discuss the Ebola vaccine trials and their experiences and perspectives of the CE activities.Results

A key aim of the CE program was to build trust between the community and the trial. Four main principles (the “four R’s”) evolved from the discussions with team members and the community that influenced this trust: reciprocity, relatability, relationships and respect. The CLT and SST ensured reciprocal communication between the trial team and the community. The CLT delivered key messages from the trial, whilst the SST completed ethnographic research in the field to uncover rumors and perceptions of the trial in the community. These ethnographic findings were shared with the CLT and addressed in targeted messaging to the community. Both the CLT and SST approached the communities in an egalitarian manner, by dressing modestly, speaking local dialects, and using relatable examples. Appreciation and understanding of the importance of interpersonal relationships and respect for the people, their customs, and traditions also played a large role in the CE program.Conclusion

These findings provide an in-depth understanding of how interdisciplinary community liaison and social science teams can work with a clinical team to strengthen trust. The four R’s suggest the ways in which trust relations are central to CE and confidence in vaccine trials, and could offer an approach to CE in vaccine trials.
Lessons learned from engaging communities for Ebola vaccine trials in Sierra Leone: Reciprocity, relatability, relationships and respect (The Four R’s)
Authors: Dada Sara , McKay Gillian , Mateus Ana L. , Lees Shelley 
Published: December 2019

Abstract
Background Building trust and engaging the community are important for biomedical trials. This was core to the set up and delivery of the EBOVAC-Salone and PREVAC Ebola vaccine trials in Sierra Leone during and following the 2014-2016 West African Ebola epidemic. Local community liaison teams (CLT) engaged with the community through public meetings, radio chat shows, and other activities, while a social science team (SST) assessed community members’ and participants’ perceptions and regularly updated the clinical team to adapt procedures to improve the acceptability and compliance of the trial. The objective of this study was to examine the community engagement (CE) program in these trials and to identify potential barriers and facilitators.Methods Fifteen CLT and SST members participated in in-depth interviews and 23 community members attended three focus groups to discuss the Ebola vaccine trials and their experiences and perspectives of the CE activities.Results A key aim of the CE program was to build trust between the community and the trial. Four main principles (the “four R’s”) evolved from the discussions with team members and the community that influenced this trust: reciprocity, relatability, relationships and respect. The CLT and SST ensured reciprocal communication between the trial team and the community. The CLT delivered key messages from the trial, whilst the SST completed ethnographic research in the field to uncover rumors and perceptions of the trial in the community. These ethnographic findings were shared with the CLT and addressed in targeted messaging to the community. Both the CLT and SST approached the communities in an egalitarian manner, by dressing modestly, speaking local dialects, and using relatable examples. Appreciation and understanding of the importance of interpersonal relationships and respect for the people, their customs, and traditions also played a large role in the CE program.Conclusion These findings provide an in-depth understanding of how interdisciplinary community liaison and social science teams can work with a clinical team to strengthen trust. The four R’s suggest the ways in which trust relations are central to CE and confidence in vaccine trials, and could offer an approach to CE in vaccine trials.
Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: A questionnaire survey from China
Authors: Li Bo , Zhang Ruidong , Huang Yue , Zhang Kan , Wat Chun Yin , Bai Jie , Zhang Mazhong , Zheng Jijian 
Published: December 2019

Abstract

Background: Moderate and deep sedation are well-established techniques in many developed countries, and several guidelines have been published. However, they have received attention in China only in recent years. The aim of this study is to investigate current paediatric sedation practices in tertiary children’s hospitals and tertiary maternity and children hospitals in China. Methods: All tertiary children’s hospitals and tertiary maternity and children hospitals registered with the National Health Commission of the People’s Republic of China were invited to participate in an electronic survey, which included information on the sedation caseload, facility availability, staff structure, clinical-skill requirements for sedation providers, fasting guidelines, patient-monitoring practices, and choice of sedatives. Results: Fifty-eight of the 63 hospitals that completed the survey (92.1%) provided moderate and deep sedation. Dedicated sedation rooms and post-sedation recovery rooms were found in only 14 (24.1%) and 19 (32.8%) hospitals, respectively. Sedation for non-invasive procedures was primarily performed by anaesthesiologists (69.0%); however, 75.9% of the sedation providers had not received paediatric basic and advanced life-support training. Children were asked to fast from clear liquids for at least 2 h in 44.8% of hospitals and at most 6 h in 5.2% of hospitals; they were asked to fast from solid food/milk for at least 4 h in 27.6% of hospitals and more than 8 h in 1.7% of hospitals. The most commonly used sedative in all groups was chloral hydrate. For rescue, propofol was the most widely used sedative, particularly for children older than 4 years. Conclusion: Moderate and deep sedation practices vary widely in tertiary children’s hospitals and tertiary maternity and children hospitals in China. More optimized practices should be established to improve the quality of moderate and deep sedation.
Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: A systematic review and meta-analysis
Authors: Ma Xueling , Lin Xuandong , Zhong Tengfei , Xie Fangfang 
Published: December 2019

Abstract
Abstract
Background: This systematic review with meta-analyses sought to answer whether casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) provided a remineralizing benefit superior to that of nonintervention or placebo.
Methods: The Cochrane databases, PubMed, EmBase, and Ovid up to May 20th, 2019, were scanned, only published in English. Study information extraction and methodological quality assessments were accomplished independently by two reviewers. The “Criteria for judging risk of bias in the ‘Risk of bias’ assessment tool” was used for methodological quality assessment. The continuous data was analyzed by mean difference (MD) or standardized mean difference (SMD) with a 95% confidence interval (CI). Review Manager 5.3 was used for statistical analysis. Outcome variables include quantitative light-induced fluorescence in clinical research, average surface roughness and surface microhardness in vitro.
Results: There were significant differences in the quantitative light-induced fluorescence (SMD = −0.43, 95% CI: [−0.79, −0.07], P = 0.02), average surface roughness (SMD = −8.21, 95% CI: [−10.37, −6.04], P < 0.01), Vickers microhardness (SMD = 1.19, 95% CI: [0.72, 1.66], P < 0.01), and Knoop microhardness (SMD = 3.52, 95% CI: [2.68, 4.36], P < 0.01) between the CPP-ACP and control groups or baseline.
Conclusion: Within the limitations of this meta-analysis, CPP-ACP exhibited excellent remineralization effects evaluated in clinical research and in vitro, indicating outstanding restoration of form, aesthetics, and function in treating white spot lesions.
Data quality of drug-resistant tuberculosis and antiretroviral therapy electronic registers in South Africa
Authors: Jamieson Lise , Evans Denise , Berhanu Rebecca , Ismail Nazir , Aucock Samantha , Wallengren Kristina , Long Lawrence 
Published: December 2019

Abstract
Background To assess the quality and completeness of treatment and outcome data in the electronic tuberculosis (TB) and antiretroviral treatment (ART) registers in drug-resistant (DR-) TB patients at three treatment facilities in South Africa. Methods We did a retrospective cohort study using routinely-collected data from DR-TB registers of rifampicin resistant adults (≥18 years old), on ART, initiating DR-TB treatment between January 2012 and December 2013. We linked patient information from the DR-TB register to the ART register using patient identifiers and an algorithm based on string edit distance and date of birth. We describe data gaps and discrepancies found. Results Overall, 2,852 DR-TB patients met our inclusion criteria based on the DR-TB register data, and of these, 1,685 (59%) could be matched to the ART registers. An additional 253 patients from the DR-TB registers were found in the ART registers, having initiated ART, despite the DR-TB register indicating that they were not on ART (or this data was missing). 11% of matched patients did not have TB treatment status recorded in the ART register despite being recorded as being on TB treatment in the DR-TB register, and 78% did not have an ART start date recorded in DR-TB register despite being on ART treatment as per the ART register. 11% of matched patients had a death recorded in one register but not the other, and of those with death recorded in both, 15% of dates differed by >1 month. Conclusions The underreporting of death and the lack of ART or TB status in the electronic DR-TB and ART registers could negatively impact monitoring efforts by downplaying the state of the TB/HIV epidemic. Improved recording of these data sources, and data integration across systems, could improve the accuracy of reporting for the national HIV/ART and TB programs.
Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies
Authors: Seifi Najmeh , Safarian Mohammad , Nematy Mohsen , Rezvani Reza , Khadem-Rezaian Majid , Sedaghat Alireza 
Published: December 2019

Abstract
Background: Among critically ill patients, regardless of the heterogeneity of disease state, an extreme and persistent dysbiosis occurs. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrients homeostasis disturbances. Methods: This is a prospective, single center, double-blind; a parallel randomized controlled trial that aimed to evaluate the effects of synbiotic supplementation on energy and macronutrient ‎homeostasis and muscle wasting in critical care patients.‎ All eligible patients (20 subjects in each group) will receive standard hospital gavage as enteral nutrition through a nasogastric tube (NGT) in the 24-48h after admission. In the intervention group, patients will receive Lactocare (ZistTakhmir) capsules 500 mg every 12h for 14 days. Patients in the control group will receive a placebo capsule which contains only the sterile maize starch and is similar to synbiotic capsules. The synbiotic and placebo capsules will be given through nasogastric tube, separately from gavage, after feeding. Discussion: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency and ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism. Trials registration: The trial protocol has been approved in Iranian Registry of Clinical Trials at 2019-03-17. The registration reference is IRCT20190227042857N1.
Knowledge of preeclampsia and its associated factors among pregnant women.: a possible link to reduce related adverse outcomes
Authors: Fondjo Linda Ahenkorah , Boamah Vivian E. , Fierti Adelaide , Gyesi Dorcas , Owiredu Eddie-Williams 
Published: December 2019

Abstract
Background: Pre-eclampsia (PE) is one of the leading causes of maternal morbidity and mortality globally. Adequate knowledge about a disorder contributes greatly to its prevention, control and management. This study assessed the level of knowledge of PE and evaluated the factors associated with knowledge adequacy among pregnant women attending antenatal care at a University Hospital in Kumasi-Ghana. Methods: This cross-sectional study was conducted at the at a University Hospital in Kumasi, Ghana. A closed-ended validated well-structured questionnaire was used to collect socio-demographic information and history of PE. Knowledge of PE was assessed based on a series of questions regarding the awareness, signs/symptoms, risk factors and complications of PE. Responses were scored percentage-wise and grouped into low (<60%), moderate (60-80%) and high (80-100%). Knowledge score was then re-stratified into adequate (% score of ≥ 60%) and inadequate knowledge of PE (% score of < 60%). Results: The prevalence of inadequate and adequate knowledge of PE was 88.6% (mean score = 55.5 ± 4.3%) and 11.4% (mean score = 76.3 ± 5.9%), respectively. For participants with adequate knowledge of PE, 9.1% (mean score = 67.4 ± 6.9%) and 2.3% (mean score = 85.2 ± 5.1%) had moderate and high knowledge, respectively. Using univariate logistic regression models, being older (>35 years old) [cOR=3.09, 95%CI (0.88-10.88), p=0.049] and having a higher level of education (> SHS education) [cOR=4.45, 95%CI (2.18-9.10), p<0.0001] were significantly associated with greater odds of having adequate knowledge of PE. After controlling for potential confounders in multivariate logistic regression analysis, we found higher level of education to be independently associated with adequate knowledge of PE [aOR=2.87, 95%CI (1.31-6.30), p=0.008]. Conclusion: The knowledge of PE among pregnant women in Ghana is low. The prominent factor that facilitates adequacy of knowledge of PE is higher level of education.