Darcy–Forchheimer hybrid nanofluid flow in a squeezing inclined channel for drug delivery applications by means of artificial neural network
Authors: Alghamdi Wajdi , Gul Taza 
Published: December 2024

PurposeHybrid nanofluids are more effective in the enhancement of heat transfer than mono nanofluids. The mono nanofluid’s thermophysical properties are limited, so it is not enough to succeed in the required thermal performance. The Darcy–Forchheimer hybrid nanofluid flow based on Ag and TiO2 has been used for the applications of drug delivery. In photoelectrochemical (PEC) biosensing applications, the detection of targets has been greatly enhanced by the use of various TiO2 nanostructures. Biosensors, drug delivery systems and medical devices can benefit greatly from the combination of Ag and TiO2.Design/methodology/approachThe Ag and TiO2 hybrid nanofluid flow in an inclined squeezing channel is considered for the applications of drug delivery. The channel walls are permeable and allow fluid in the form of suction and injection, while the flow medium inside the channel is also nonlinearly porous. A set of nonlinear differential equations is created from the main governing equations. The model problem is solved by using the artificial neural network (ANN), and the results are plotted and discussed. Recent and past results have been observed to have a strong correlation.FindingsIt can be concluded that the contracted and expanding parameter nature is the main factor in controlling hybrid nanofluid flow in the inclined squeezing flow. The values of the other parameters vary the profile’s growth. The central zone has the lowest absolute value of normal pressure drop for the pair of cases with positive or negative Reynolds. The lower heated wall becomes more efficient when the increase is used with a 5% volume fraction. The lower wall has an increasing percentage of 6.9% and 9.75% when using nanofluid and hybrid nanofluid, respectively.Research limitations/implicationsThe authors believe that no one has ever investigated the Darci–Forchheimer flow in a squeezing inclined channel for medical applications. The physical properties of the Ag and TiO2 hybrid nanofluid make it suitable for use as a medication in the biomedical field. The ANN is also a novel approach to solving the current problem. This research is focused on stabilizing hybrid nanofluid flow in the squeezing and porous channels by optimizing normal pressure under the influence of embedded parameters. This main part of the research is not usually mentioned in the existing literature.Practical implicationsHybrid nanofluids can effectively utilize the antimicrobial properties of TiO2 and Ag nanomaterials for drug delivery applications due to their unique properties. Ag and TiO2 nanomaterials have the ability to control temperature distribution during the flow in an inclined channel, which is crucial for uniform drug delivery. Controlling the release rate of drugs and maintaining the flow stability is largely dependent upon the increase in temperature. The Ag and TiO2 nanoparticles are effective in localized hyperthermia treatments, and this procedure necessitates a temperature higher than the body’s temperature. Therefore, increasing the temperature profile is essential for drug delivery.Social implicationsHybrid nanofluids can effectively utilize the antimicrobial properties of TiO2 and Ag nanomaterials for drug delivery applications due to their unique properties. Ag and TiO2 nanomaterials have the ability to control temperature distribution during the flow in an inclined channel, which is crucial for uniform drug delivery. Controlling the release rate of drugs and maintaining the flow stability is largely dependent upon the increase in temperature. The Ag and TiO2 nanoparticles are effective in localized hyperthermia treatments, and this procedure necessitates a temperature higher than the body’s temperature. Therefore, increasing the temperature profile is essential for drug delivery.Originality/valueThe authors believe that no one has ever investigated the Darci–Forchheimer flow in a squeezing channel for medical applications. Moreover, the walls of the channel and the flow medium are both porous. The physical properties of the Ag and TiO2 hybrid nanofluid make it suitable for use as a medication in the biomedical field. The idea of a hybrid nanofluid flow in a squeeze channel using blood-based Ag and TiO2 is also new and important for drug delivery applications. The ANN is also a novel approach to solving the current problem.