bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the metric dimensions of graphene: Unveiling the intricacies of its atomic structure
Authors: Abbas Wasim , Chaudhry Faryal , Farooq Umar , Baber Muhammad Zafarullah , Sulaiman Tukur Abdulkadir 
Published: December 2024

Graphene, celebrated for its remarkable atomic structure, stands as a key material in diverse fields such as nanoelectronics and materials science. This paper presents a thorough investigation into the metric dimensions of graphene, emphasizing its unique spatial properties and their broad implications. We analyze how these metric dimensions affect graphene’s electrical, thermal, and mechanical behavior in various applications. Our study delves into the physical mechanisms behind these properties, including atomic interactions, lattice dynamics, and external factors like temperature and pressure. The metric dimension of a graph G is the minimum cardinality of a subset [Formula: see text] such that every pair of distinct vertices [Formula: see text] is uniquely identified by their distance vectors relative to W and the resolving set, ensures for any [Formula: see text] with [Formula: see text], there exists a vertex [Formula: see text] such that [Formula: see text], where d denotes the distance function in G. In this work, we will determine the metric dimension and Resolving set. However, these findings pave the way for innovative applications in electronics, composites, and beyond.
Data Breach Disclosure Laws and Social Responsibility Initiatives
Authors: Zhang Yanlei 
Published: December 2024

Synopsis The research problem This study investigated how firms employ corporate social responsibility (CSR) as a precautionary strategy in response to heightened concerns about cybersecurity following the adoption of data breach disclosure laws in the United States. Motivation CSR has garnered substantial attention in contemporary society. Simultaneously, the last few decades have witnessed a rapid surge of the digital economy. However, it remains unclear how CSR is adapting to digitalization. In this study, I focused on cybersecurity, a pivotal challenge in the digital age. Theoretical reasoning The enactment of data breach disclosure laws enhances the reporting of cybersecurity incidents and intensifies concerns about cybersecurity, promoting firms to take measures to mitigate the adverse impacts of data breaches. Building on the theory that CSR functions like an insurance policy, I hypothesized that firms increase their engagement in CSR to fortify their reputation after the enactment of data breach disclosure laws, helping cushion the potential impact of future breaches. Analyses The main analysis employed a difference-in-differences research design to compare the changes in CSR engagement between firms with high and low levels of cybersecurity risk following the enactment of data breach disclosure laws in the United States. Cross-sectional analyses delved into the underlying mechanisms. Additional analyses first explored the role of CSR in mitigating stock price decline and then illustrated reputational concerns after data breaches. Findings The main analysis showed that firms with high cybersecurity risk increase their CSR engagement to a greater extent following the adoption of data breach disclosure laws. CSR initiatives are particularly pronounced for firms likely to incur significant losses from data breaches, aligning with the theoretical framework and offering insight into the underlying mechanisms. I also found that firms with fewer financial constraints exhibit stronger CSR initiatives. Furthermore, these CSR initiatives are distinct and cannot be substituted by investments in information technology. The additional analysis illustrates that firms with superior CSR performance undergo a smaller stock price decline surrounding data breach announcements. This supports the notion that CSR functions much like insurance, shielding against the impacts of data breaches. Subsequently, this study presents direct evidence on firms’ concerns regarding the reputational impact of cybersecurity. Overall, this study underscores cybersecurity concerns as a driving force behind social responsibility initiatives in this digital era. Target population This research holds significance for policymakers worldwide who are considering cybersecurity-related regulations and for firms seeking effective risk management strategies in the face of cybersecurity challenges.
The Changing Incidence of Malaria in Indonesia: A 9‐Year Analysis of Surveillance Data
Authors: Aisyah Dewi Nur , Sitompul Desrina , Diva Haniena , Tirmizi Siti Nadia , Hakim Lukman , Surya Asik , Puspadewi Riskha Tiara , Prameswari Helen Dewi , Adisasmito Wiku , Manikam Logan 
Published: December 2024

Objectives: This study aims to track the spatiotemporal incidence rate and endemicity of malaria in 34 provinces of Indonesia from 2014 to 2022 using surveillance data, commenting on trends observed and deriving implications for public health practice for combating malaria in Indonesia.Methods: This paper is a longitudinal study using routinely collected public health surveillance data. We calculated the incidence rate as both total cases and the number of cases per 1000 person‐years at the provincial level. The endemicity was mapped as the annual parasite index (API) per 1000 at‐risk populations. Trends in malaria incidence rate and endemicity were examined descriptively in Excel Version 16.83.Results: Nationally, malaria incidence increased by 191,503 from 2014 to 2022. The API at the national level rose by 62.63% from 0.99 cases per 1000 at‐risk populations in 2014 to 1.61 in 2022. Despite the national increase, the endemicity of Sumatra Island and Kalimantan showed strong progress (API less than 1 per 1000 at‐risk population). The incidence and endemicity of malaria remain high in the Eastern Islands, particularly in the provinces of Papua and West Papua. The Eastern Islands accounted for 95.73% (424,569 cases of total cases 443,530) of national cases in 2022.Conclusions: Progress has been made in province‐level malaria elimination, especially outside Papua and West Papua. To prevent the persistence of endemic malaria pockets in Papua and West Papua, there is a need for greater coordination of and further dedication of financial resources toward efforts to eliminate malaria in these provinces. These efforts should be supported by an improvement in surveillance capacity, the inclusion of information on the parasite species responsible for malaria cases in routine surveillance initiatives, and the use of culturally tailored interventions to maximize health‐seeking behaviors and intervention uptake.
The Mechanism of Doctor–Patient Trust in the Hierarchical Diagnosis and Treatment System (HDTS) From the Perspective of Tripartite Evolutionary Game
Authors: Li Lele , Tian Mengyi 
Published: December 2024

Objective: Doctor–patient trust, especially patients’ trust in doctors, represents patients’ compliance with doctors’ behavior and may affect patients’ choice of medical treatment behavior. This paper aims to delve into the profound impact of doctor–patient trust on the hierarchical diagnosis and treatment system. Additionally, it formulates corresponding policy suggestions for reforming this system from a practical perspective, offering a useful reference for the development of both the theory and practice of China’s healthcare protections.Methods: In this paper, the rank‐dependent expected utility theory was used to construct a tripartite evolutionary game model of hierarchical diagnosis and treatment system for observing the interactions and behaviors between superior hospitals, primary hospitals, and patients under different levels of doctor–patient trust. Meanwhile, descriptive statistics and binary logistic regression methods were used in empirical research for revealing the specific mechanism.Results: When the doctor–patient trust is at a high level, it is easier for each participant in the hierarchical diagnosis and treatment system to choose cooperative strategies, thus enabling the system to operate smoothly. Specifically, the medical level of healthcare institutions exerts a significantly positive impact on the level of doctor–patient trust and concurrently, an enhanced level of doctor–patient trust promotes patients’ adherence to the hierarchical diagnosis and treatment system when making healthcare choices.Conclusions: Doctor–patient trust is a significant bridge connecting medical institutions and patients. It is an important factor to realize the orderly operation of hierarchical diagnosis and treatment system. To attain the objective of strengthening doctor–patient trust and fostering the smooth functioning of the hierarchical diagnosis and treatment system, it is essential to capitalize on policy mechanism to motivate healthcare service providers to enhance their medical capabilities and gradually guide patients to make healthcare choices in an orderly manner according to the system design.
Multivariable Analysis of Correlation Between Anatomical Features of Mandibular Third Molars and Pericoronitis
Authors: Nguyen Bao-Ngoc Thi , Nguyen-Le Chi-Tam , Nguyen Bich-Ly Thi , Le Son Hoang 
Published: December 2024

Objective: The correlation between anatomy features of impacted mandibular third molars (M3Ms) and prevalence of pericoronitis was only interpreted using univariate analysis. This study investigated this correlation using multivariable analysis to determine the relationship between pericoronitis prevalence and the M3Ms’ anatomical features.Methods: This cross‐sectional study recruited 245 patients with 338 impacted M3Ms. One researcher collected participants’ demographic characteristics such as sexes, age, side, and pericoronitis condition. The radiographic characteristics of M3Ms, including eruption direction and impacted levels according to Pell–Gregory classification, were assessed based on their orthopantomograms. Initially, univariate analyses were used to determine potential demographic and radiographic factors that correlated to pericoronitis. These factors were, then, analyzes using Firth’s logistic regression.Results: No significant difference was found between non‐ and pericoronitis groups about sexes, age, side (p  > 0.05). The univariate analyses showed that proportion of vertical impacted levels and eruption direction of M3Ms were significantly different between non‐ and pericoronitis groups. Firth’s logistic regression analysis indicated that M3Ms with impacted level A were more likely to suffer from pericoronitis than ones at level B (odds ratio (OR) = 3.34), wheraes M3Ms impacted level II had higher risk of pericorinitis than ones at level I (OR = 1.63). Vertical M3Ms were more likely to develop pericoronitis than horizontal (OR = 5.78) ones.Conclusion: M3M angulation and impacted level are significant factors relating to pericoronitis prevalence. M3Ms with vertical eruption, vertically level A, and horizontally level B are more likely to have pericoronitis.
CXCL12-Targeted Immunomodulatory Gene Therapy Reduces Radiation-Induced Fibrosis in Healthy Tissues
Authors: Paget James T. , Ward Joseph A. , McKean Andrew R. , Mansfield David C. , McLaughlin Martin , Kyula-Currie Joan N. , Smith Henry G. , Roulstone Victoria , Li Chunhei , Zhou You , Hardiman Thomas , Grigoriadis Anita , O’Brien Coon Devin , Irshad Sheeba , Melcher Alan A. , Harrington Kevin J. , Khan Aadil 
Published: December 2024

Abstract
Radiation-induced fibrosis (RIF) is a progressive pathology deleteriously impacting cancer survivorship. CXCL12 is an immune–stromal signal implicated in fibrosis and innate response. We hypothesized that modulation of CXCL12 would phenotypically mitigate RIF. CXCL12 expression was characterized in a rodent model of RIF and its expression modulated by the intravascular delivery of lentiviral vectors encoding small hairpin RNA to silence (LVShCXCL12) or overexpress (LVOeCXCL12) CXCL12. Multimodal fibrotic outcomes were quantified, and flow cytometry and Y-chromosome lineage-tracking studies performed to examine cellular recruitment and activation after radiotherapy. Whole-tissue RNA sequencing was used to examine matrisomal response. MATBIII tumors were engrafted within tissues with differing levels of CXCL12 expression, and tumoral response to RT was evaluated. CXCL12 was upregulated in irradiated fibroblasts demonstrating DNA damage after radiotherapy, which led to the recruitment of CD68+ macrophages. Silencing CXCL12 with LVShCXCL12 demonstrated reduced RIF phenotype as a result of decreased macrophage recruitment. Transcriptomic profiling identified osteopontin (OPN; SPP1) as being highly differentially expressed in LVShCXCL12-treated tissues. Tumors growing in tissues devoid of CXCL12 expression responded better after RT because of reductions in peritumoral fibrosis as a result of decreased CXCL12 and OPN expression at the tumor/normal tissue interface. This was also associated with greater CD8+ T-cell infiltration in tumors with less fibrosis. Antibody-mediated OPN blockade slowed tumor growth by increased intratumoral CD8+ T-cell activation. The CXCL12/OPN axis is an important node of immune/matrisomal cross-talk in the development of fibrosis. Therapeutic manipulation of this axis may offer greater antitumor efficacy while also reducing adverse effects.
The FcγRIIIA (CD16) L48-H/R Polymorphism Enhances NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity by Promoting Serial Killing
Authors: Maskalenko Nicholas A. , Zahroun Sam , Tsygankova Oxana , Anikeeva Nadia , Sykulev Yuri , Campbell Kerry S. 
Published: December 2024

Abstract
Many tumor-specific monoclonal antibody therapies stimulate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells through FcγRIIIa (CD16). The efficacy of these ADCC-based immunotherapies is potentiated in patients with the common CD16 polymorphic variant F158-V that increases the binding affinity between the receptor and the IgG Fc domain. However, other CD16 variants are less well characterized. Here, we report that CD16 L48-H and L48-R variants both significantly enhance in vitro ADCC responses in primary NK cells and NK-92 cells. During ADCC responses, NK cells expressing CD16 48-H killed and disengaged from target cells faster than those expressing CD16 48-L, resulting in improved serial killing of tumor cells. We found that CD16 48-H also formed an immunologic synapse with a more compact interface, as well as more robust intracellular calcium signaling and quicker polarization of cytolytic vesicles. The ADCC response observed occurs due to increased cytolytic signaling and target cell disengagement, which drives NK cell–mediated serial killing of tumor cells. The L48-H/R polymorphism has potential to benefit patient responses to cancer antibody therapies and may also potentiate antitumor ADCC responses if incorporated into adoptive NK cell therapeutic platforms.
Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia
Authors: Sonowal Himangshu , Rice William G. , Bejar Raphael , Byun Joo-Yun , Jung Seung Hyun , Sinha Ranjeet , Howell Stephen B. 
Published: December 2024

Abstract
Tuspetinib (TUS) is a well-tolerated, once daily, oral kinase inhibitor in clinical development for treatment of acute myeloid leukemia (AML). Nonclinical studies show that TUS targets key prosurvival kinases with IC50 values in the low nmol/L range, including SYK, wild-type (WT) and mutant forms of FLT3, mutant but not WT forms of KIT, RSK2, and TAK1–TAB1 kinases, and indirectly suppresses expression of MCL1. Oral TUS markedly extended survival in subcutaneously and orthotopically inoculated xenograft models of FLT3-mutant human AML, was well tolerated, and delivered enhanced activity when combined with venetoclax (VEN) or 5-azacytidine. In vitro, TUS demonstrated potent killing of AML lines [concentration needed to reduce the growth of treated cells to half that of untreated cells (GI50) = 1.3–5.2 nmol/L] and Ba/F3 cells expressing WT (GI50 = 9.1 nmol/L) or various mutant forms of FLT3 (GI50 = 2.5–56 nmol/L). In AML lines, the multikinase targeting capacity of TUS suppressed phosphorylation of SYK, FLT3, STAT5, MEK, ERK, AKT, mTOR, 4E-BP1, and S6K kinases. Cells selected for stable acquired resistance to TUS exhibited increased BAX and hypersensitivity to VEN (1900 fold), navitoclax, and MCL1 inhibitors. MV-4-11 FLT3-ITD clones expressing NRASG12D revealed that high-level expression of NRASG12D generated modest resistance to TUS and greater resistance to VEN, yet the TUS/VEN combination exhibited synergy in the NRASG12D AML model. Favorable preclinical safety and pharmacology properties, the efficacy of the TUS/VEN combination in a murine model, and the synthetic lethal vulnerability to VEN that accompanies TUS resistance provide the basis for exploration of the TUS/VEN combination in patients with relapsed or refractory AML.

Significance:
This article reports preclinical development of TUS, an oral kinase inhibitor currently in clinical development for treatment of AML. The article covers the studies of TUS activities on cellular targets and the nonclinical studies that supported the advancement of TUS to a phase I/II trial of TUS/VEN in refractory AML and a phase I/II trial of TUS/VEN/5-azacytidine in newly diagnosed patients with AML (NCT03850574).
Extracellular Vesicles From Preeclampsia Disrupt the Blood-Brain Barrier by Reducing CLDN5
Authors: Sandoval Hermes , Ibáñez Belén , Contreras Moisés , Troncoso Felipe , Castro Fidel O. , Caamaño Diego , Mendez Lidice , Escudero-Guevara Estefanny , Nualart Francisco , Mistry Hiten D. , Kurlak Lesia O. , Vatish Manu , Acurio Jesenia , Escudero Carlos 
Published: December 2024

BACKGROUND:
The physiopathology of life-threatening cerebrovascular complications in preeclampsia is unknown. We investigated whether disruption of the blood-brain barrier, generated using circulating small extracellular vesicles (sEVs) from women with preeclampsia or placentae cultured under hypoxic conditions, impairs the expression of tight junction proteins, such as CLDN5 (claudin-5), mediated by VEGF (vascular endothelial growth factor), and activation of KDR (VEGFR2 [VEGF receptor 2]).

METHODS:
We perform a preclinical mechanistic study using sEVs isolated from plasma of pregnant women with normal pregnancy (sEVs-NP; n=9), sEVs isolated from plasma of women with preeclampsia (sEVs-PE; n=9), or sEVs isolated from placentas cultured in normoxia (sEVs-Nor; n=10) or sEVs isolated from placentas cultured in hypoxia (sEVs-Hyp; n=10). The integrity of the blood-brain barrier was evaluated using in vitro (human [hCMEC/D3] and mouse [BEND/3 (brain endothelial cell 3)] brain endothelial cell lines) and in vivo (nonpregnant C57BL/6J mice [4–5 months old; n=13] injected with sEVs-Hyp) models.

RESULTS:

sEVs-PE and sEVs-Hyp reduced total and membrane-associated protein CLDN5 levels (
P
<0.05). These results were negated with sEVs-PE sonication. sEVs-Hyp injected into nonpregnant mice generated neurological deficits and blood-brain barrier disruption, specifically in the posterior area of the brain, associated with brain endothelial cell uptake of sEVs, sEVs-Hyp high extravasation, and reduction in CLDN5 levels in the brain cortex. Furthermore, sEVs-PE and sEVs-sHyp had higher VEGF levels than sEVs-NP and sEVs-Nor. Human brain endothelial cells exposed to sEVs-PE exhibited a reduction in the activation of KDR. Reduction in CLDN5 observed in cells treated with sEVs-Hyp was further enhanced in cells treated with KDR selective inhibitor.

CONCLUSIONS:
sEVs-PE disrupts the blood-brain barrier, an effect replicated with sEVs-Hyp, and involves reduced CLDN5 and elevated VEGF contained within these vesicles. However, our results do not support the participation of KDR activation in the downregulation of CLDN5 observed with sEVs-Hyp. These findings will improve our understanding of the pathophysiology of cerebrovascular alterations in women with preeclampsia.
Nervous Extensions for Planetary Balance in Nina Sobell’s Collaborative Séances
Authors: Albu Cristina 
Published: December 2024

Abstract
Artist Nina Sobell uses electronic media to unveil the invisible ties between ourselves and others. Addressing the transformative potential of nonverbal communication, the author analyzes Meditations, Memory, Dream, Fantasy and Solar Wind Weaving Sun and Moon, Sharing a Shadow, two collaborative projects created by Sobell in 1999 to inspire collective acts of imagination. Merging images of brainwave oscillations with video feedback and automatic drawing, these participatory artworks elicit a heightened sense of embodied presence and emphasize the interdependence between planetary and human rhythms.
Tracking the origin and current distribution of wall lizards (Podarcis spp.) in Poland
Authors: Kowalik Carmen , Skawiński Tomasz , Boesl Dominik , Celiński Damian , Jablonski Daniel , Kolenda Krzysztof 
Published: December 2024

Abstract
Among the most successful European reptilian invaders are lizards of the genus Podarcis. Human activities have facilitated the spread of these lizards beyond their native range, often establishing thriving populations in new locations. Poland lies beyond the northern range of all Podarcis species, but between 2011 and 2014, three populations representing the Central Balkan clade of P. muralis were discovered in the Strzelin Hills (SW Poland). Our aim was to determine the current distribution and introduction routes of Podarcis lizards into Poland. We searched for P. muralis in 44 additional localities (with conditions known to be preferred by the species in Central Europe, such as ruins of abandoned buildings, railway stations, and quarries) in the Strzelin Hills as well as surveyed literature sources and online platforms to identify cases of introduction of Podarcis lizards into Poland. No new sites with P. muralis have been discovered in the Strzelin Hills and the occurrence of the species in this area is limited to three already known sites. Nine cases of the introduction of wall lizards were confirmed. These ranged from single individuals of P. muralis or P. siculus introduced via freight transport and captured immediately after, to two introductions of P. muralis that resulted in the establishment of populations that persisted for at least several years. Molecular analyses showed that the introduced lizards originated from several ‘exotic’ lineages (i.e., not the Central Balkan clade) from Italy and Croatia, although secondary introductions are possible. Given the ability of southern lineages to establish viable populations in Poland, continued monitoring is essential.