bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE RELATIONSHIP BETWEEN OLDER DRIVERS’ RESILIENCE AND SELF-REPORTED DRIVING MEASURES OVER 5 YEARS
Authors: Louis Renée M St , Charlton Judith , Koppel Sjaan , Molnar Lisa J , Stefano Marilyn Di , Darzins Peteris , Bédard Michel , Marshall Shawn 
Published: November 2019

Abstract
As people age into older adulthood, they are more likely to experience events that impact their driving, such as age-related cognitive and functional declines, serious illness, or disability. The ability to demonstrate resilience following such adversity may influence one’s decisions and feelings about driving. This study investigated whether resilience of older drivers changes over time, and if relationships between resilience, gender, and self-reported driving-related abilities, perceptions and practices remain stable or change. Participants were from the Candrive/Ozcandrive study, a prospective cohort study of older drivers from Canada, Australia and New Zealand. Analyses are presented from a subset of Ozcandrive participants (n=125) from Australia who completed a resilience scale at two time points approximately five years apart, as well as measures of driving comfort during the day and night, perceived driving abilities, and driving frequency. Participants were primarily male (67.2%) with a mean age of 81.6 years (SD=3.3, Range=76.0-90.0) at Time 1. Resilience increased significantly from Time 1 to Time 2 (Median=82.0/84.00, z=-2.9, p&lt;.01). Although females had significantly higher resilience than males at both Time 1 (Median=84.0/81.0, U=2.3, p=.02) and Time 2 (Median=86.5/82.0, U=2.1, p=.03), there was a statistically significant increase in resilience of males over five years (p&lt;.01) and no statistical change for females. Results show small but significant positive correlations, and increasingly stronger relationships over time between older drivers’ resilience and driving comfort as well as perceived driving abilities. Future research will use modelling to examine the association of various factors on the change in resilience and driving-related measures.
INTEREST GROUP SESSION—RAINBOW RESEARCH GROUP: ADAPTING AN EVIDENCE-BASED INTERVENTION TO LGBT ADULTS WITH DEMENTIA AND CARE PARTNERS: MOBILIZING SUPPORT NETWORKS
Authors: Goldsen Karen Fredriksen , Teri Linda 
Published: November 2019

Abstract
LGBT (lesbian, gay, bisexual, and transgender) older adults have been found to have elevated risks of cognitive impairment. Maintaining quality of life is a challenge for those experiencing cognitive decline and their caregivers. Whereas support networks are essential for quality of life, LGBT older adults with dementia may face unique risks, such as stigma, social isolation, lack of family support, and barriers to healthcare. Aging with Pride: IDEA (Innovations in Dementia Empowerment and Action), is the first federally funded clinical trial to test an intervention designed to improve quality of life of LGBT older adults with dementia and caregivers adapting a preexisting program teaching behavioral strategies and physical exercises. The intervention incorporated empirical findings from a longitudinal study, Aging with Pride: National Health, Aging, and Sexuality/Gender Study (NHAS) and developed innovative and culturally responsive approaches. Kim and colleagues examine predictors of longitudinal changes in physical functioning among LGBT older adults with cognitive impairment focusing on physical, social, and recreational activities as well as stigma. Emlet and colleagues investigate caregiving experiences among LGBT older adults and identify factors that are associated with their physical and mental health. Lastly, Fredriksen Goldsen and colleagues introduce how the modifiable factors identified from the Aging with Pride: NHAS were incorporated in the IDEA intervention and evaluate the processes of the culturally-responsive approaches implemented in the study. The presentations in this symposium illustrate the importance of tailoring clinical trial studies for hard-to-reach and underserved populations with dementia responding to their unique health needs.
LESSONS LEARNED FROM THE FIRST INTERVENTION STUDY ADDRESSING DEMENTIA IN THE LGBT COMMUNITY
Authors: Goldsen Karen Fredriksen , Fredriksen-Goldsen Karen , Teri Linda , Kim Hyun-Jun , McKenzie Glenise , Fazia David La , Emlet Charles , Petros Ryan 
Published: November 2019

Abstract
The cognitive health needs of LGBT older adults have not been adequately addressed in mainstream clinical trials. Aging with Pride: IDEA (Innovations in Dementia Empowerment and Action), is an intervention designed to improve physical functioning and quality of life of LGBT adults with dementia and caregivers. We evaluate the processes and effectiveness of culturally-responsive recruitment approaches implemented in this study. A strong research-community partnership was necessary for the development and implementation of the intervention. LGBT participants with dementia made the first contact to research team as often as caregivers did and showed a higher rate of living alone and having a friend-based care network. The most common reason for ineligibility was not having a caregiver. Participants learned about the study via multiple venues including community events, newsletters, and social media. This study illustrates important new ways to sustain collaborations with disadvantaged communities and conduct a clinical trial with hard-to-reach participants.
THE POTENTIAL AND PITFALLS OF GAMIFICATION TO SUPPORT OLDER ADULTS' ADHERENCE TO HEALTHCARE INTERVENTIONS
Authors: Boot Walter R , Charness Neil 
Published: November 2019

Abstract
The addition of video game-like elements to non-game activities, known as gamification, holds promise with respect to encouraging engagement with, and adherence to, health behaviors and healthcare interventions. Elements of gamification include the introduction of points systems, leaderboards, achievement badges, stories and themes, rewards, progress tracking, and challenges. However, a lack of enthusiasm for, and experience with, video game play by older adults has important implications for the effectiveness of these techniques across the lifespan. Specifically, the age-related “digital divide” must be considered before applying these approaches to improving the wellbeing, cognition, and health of older adults. This talk will build on the body of research conducted by the Center for Research and Education on Aging and Technology Enhancement (CREATE) focused on gaming and interventions to present best practice guidelines for implementing gamification with older adults.
A CASE ARGUMENT FOR AGE DIVERSITY ON CAMPUS
Authors: Morrow-Howell Nancy , Lawlor Edward , Macias Ed , Swinford Emma , Brandt Jeffrey 
Published: November 2019

Abstract
Washington University for Life is an initiative to increase age-diversity on campus, especially in degree and certificate programs. We have developed a case argument for educating people across the longer life course; and we identify positive outcomes for society, younger students, the institution, and for older adults themselves. These arguments do not include the reality that the supply of young students will be constrained, as this demographic press is not viewed as threatening by many U.S. universities. This argument is being presented to administrators, admission and career service personnel, and classroom instructors, who do not universally accept the benefits, much less the necessity, of increased age-diversity; and they often express resistance to disrupting traditional practices with only the well-being of older adults in mind. A full discussion of reasons that Washington University should move purposively toward age inclusivity is important to build consensus and identify opportunities for new practices.
BUILDING RECOGNITION ACROSS CAMPUS AND TOWN FOR USC’S AGE-FRIENDLY UNIVERSITY INITIATIVE
Authors: Nash Paul , Nash Paul , Cicero Caroline 
Published: November 2019

Abstract
Details of efforts to highlight existing age-related programming on campus, create a new intergenerational experiential learning program, build a social media presence, and include ‘age’ in the university’s diversity efforts will be discussed. Best practices in community engagement will be emphasized including successes with retired employees, alumni, activities programming, and local age-friendly efforts. Discussion includes the benefits of developing a multidisciplinary working group to ensure the Initiative is a university wide effort and the challenges of working in a large, multi-campus research university located in multilayered bureaucratic local jurisdictions. Future goals and collaboration with AFU Global Network partners and aspirations for addressing societal ageism will be addressed.
A NOVEL METABOLITE COMPOSITE SCORE EXPLAINS THE HIGHER MORTALITY ASSOCIATED WITH FRAILTY AMONG OLDER BLACK MEN
Authors: Marron Megan M , Harris Tamara B , Boudreau Robert M , Moore Steven C , Sanders Jason L , Wendell Stacy G , Zmuda Joseph M , Newman Anne B 
Published: November 2019

Abstract
Frailty is more prevalent among black versus white older Americans. We previously sought to better characterize frailty among 287 black men ages 70-81 by identifying 37 plasma metabolites associated with vigor to frailty using the scale of aging vigor in epidemiology (SAVE). Using this information, we developed a metabolite score to determine if it explained the frailty-associated higher mortality. The Human Metabolome Database classified the metabolites as organic acids/derivatives (m=14), lipids/lipid-like molecules (m=12), organoheterocyclic compounds (m=4), benzenoids (m=3), organic nitrogen compounds (m=2), organic oxygen compounds (m=1), and nucleosides/nucleotides/analogues (m=1). Values for each were ranked into tertiles. The metabolite tertile associated with more vigorous SAVE scores was given a score of 0, the metabolite mid-tertile a score of 1, and the metabolite tertile associated with frailer SAVE scores a score of 2. The metabolite composite score was calculated as the sum of the metabolite tertile scores. One standard deviation frailer SAVE was associated with 30% higher mortality (p=0.0002), adjusting for age and study site. The association between frailty and mortality was attenuated by 56% after additionally adjusting for the metabolite score, where organic acids/derivatives and lipids/lipid-like molecules (mostly amino acids, glycerophospholipids, sphingolipids) accounted for most of the attenuation. In this model, one standard deviation higher metabolite score was associated with 46% higher mortality (p&lt;0.0001). The metabolite score also predicted mortality among 48 community-dwelling (96% white) older men (p=0.03). These metabolites provide a deeper characterization of frailty that reproducibly explains a substantial portion of the vulnerability to death in these older men.
LINKAGES BETWEEN INDIGENOUS CULTURAL GENERATIVITY AND SOBRIETY TO PROMOTE ALASKA NATIVE SUCCESSFUL AGING
Authors: Lewis Jordan P 
Published: November 2019

Abstract
The aim of this study was to explore motivating and maintenance factors for sobriety among older AN adult participants (age 50+) from across Alaska. Ten life history narratives of Alaska Native older adults, representing Alutiiq, Athabascan, Tlingit, Yup’ik/Cup’ik Eskimos, from the PA sample were explored using thematic analysis. AN older adults are motivated to abstain from, or to quit drinking alcohol through spirituality, family influence, role socialization and others’ role modeling, and a desire to engage in indigenous cultural generative activities with their family and community. A desire to pass on their accumulated wisdom to a younger generation through engagement and sharing of culturally grounded activities and values, or indigenous cultural generativity, is a central unifying motivational and maintenance factor for sobriety. The implications of this research indicate that family, role expectations and socialization, desire for community and culture engagement, and spirituality are central features to both AN Elders’ understanding of sobriety and more broadly, to their successful aging. Future research is needed to test these findings in population-based studies and to explore incorpo- ration of these findings into alcohol treatment programs to support older AN adults’ desire to quit drinking and attain long-term sobriety. Sobriety can put older AN adults on a pathway to successful aging, in positions to serve as role models for their family and community, where they are provided opportunities to engage in meaningful indigenous cultural generative acts.
SENSE OF PURPOSE IN LIFE AND REDUCED LIKELIHOOD OF FUTURE DRUG MISUSE
Authors: Kim Eric S , Ryff Carol , Hassett Afton , Brummett Chad , Yeh Charlotte , Strecher Victor 
Published: November 2019

Abstract
A stronger sense of purpose in life is hypothesized to reduce the likelihood of drug misuse because it has been linked with several protective factors including: increased ability to handle stress and pain tolerance, decreased impulsivity, and reduced risk of depression and chronic conditions. However, the association between purpose in life and drug misuse has been understudied. We tested whether people with a stronger sense of purpose in life had a decreased likelihood of incident drug misuse 9-10 years later. We also tested whether people with a stronger sense of purpose were less likely to cope with stress by misusing drugs. Participants were drawn from the Midlife in the United States Study (MIDUS; n=3,483) and from a stress coping module of the Health and Retirement Study (HRS; n=498). Among MIDUS respondents not misusing drugs at baseline, people in the highest quartile of purpose (compared to people in the lowest quartile) had 42% reduced odds (95% CI: 0.37-0.92) of incident drug misuse 9-10 years later in the fully-adjusted model (e.g., sociodemographic factors, depression, chronic conditions, and chronic pain). Among HRS respondents, people in the highest purpose quartile had 65% decreased odds (95% CI: 0.14-0.89) of misusing drugs to cope with stress in the fully-adjusted model. A growing number of intervention studies show that purpose in life can be raised. With additional research, these data suggest that sensitively tailored and administered purpose in life may reduce the likelihood of drug misuse and help stem the tide of our nation’s growing drug epidemic.
INTEGRATIVE ANALYSIS OF ALZHEIMER’S DISEASE GWAS TO DEVELOP A NEW POLYGENIC PREDICTOR AND TEST BIOSOCIAL ETIOLOGY
Authors: Harrati Amal 
Published: November 2019

Abstract
Alzheimer’s disease (AD) has genetic and environmental causes and etiology is thought to reflect interplay among these factors. A barrier to integration of genetic and environmental etiologic factors in research to inform prevention and intervention is poor understanding of AD genetics beyond APOE4. We used the new Genomic SEM methodology to conduct integrative analysis of results from several AD genome-wide association studies (GWAS), including brain-imaging and autopsy AD GWAS, to derive a novel, polygenic genetic predictor of AD. We applied this polygenic predictor in the US Health and Retirement Study to test associations with (1) cognitive aging measured from repeated-measures longitudinal cognitive-test data; and (2) blood-chemistry-based biological age algorithms. In further exploratory analysis, we tested if risk measured by the novel AD polygenic predictor was correlated with and/or buffered by a known environmental factor influencing AD etiology, life-course socioeconomic position. Results map new directions for biosocial AD research.
REVERSE TRANSLATION OF HUMAN BIO-AGING MEASURES TO CYNOMOLGUS MONKEYS TO TEST ASSOCIATIONS WITH DOMINANCE RANK
Authors: Snyder-Mackler Noah , Shively Carol , Register Tom , Belsky Daniel W 
Published: November 2019

Abstract
Social status is a powerful correlate of aging-related health decline. Observational data in humans suggest that disadvantaged social status may be associated with accelerated biological aging. But establishing causality in this relationship poses challenges; experimental manipulation of human social status is not possible. In contrast, social status can be experimentally manipulated non-human primates (e.g. Snyder-Mackler 2016 Science). We conducted analysis to reverse-translate blood-chemistry of biological aging to cynomolgus monkeys using data from several hundred animals in the Wake Primate Center breeding colony. We are applying these measures in an independent sample of monkeys with ascertained dominance rank to test replication in the non-human primate model of the human social gradient in biological aging. Parallel analysis of DNA methylation-based measures of biological aging are ongoing and should be available to present by Fall 2019. Results will inform potential to use this non-human primate model to study social determinants of biological aging.
IS SELF-RATED HEALTH A WINDOW ONTO THE BIOLOGY OF HEALTH AND AGING?
Authors: Belsky Daniel W 
Published: November 2019

Abstract
Self-ratings of health predict survival in older adults, suggesting that they capture important information about system integrity. We analyzed epigenetic clock, blood biochemistry, and functional test data alongside participant reports of disability, morbidity, and self-rated health in population-based cross-sectional and longitudinal datasets from the US and UK (total N&gt;50,000) and in a randomized trial of caloric restriction (N=220). We (1) profiled cross-sectional biomarker correlates of self-rated health; (2) quantified residual biomarker associations with self-rated health after accounting for research-participant reports of morbidity and disability and evaluated variation in associations across strata of age, birth-cohort cohort, socioeconomic status, and cognitive functioning; and (3) tested coordinated change in biomarker indices of system integrity and self-ratings of health in response to caloric restriction. Results develop an understanding of self-rated health as a window onto biological processes of aging and highlight important design considerations for future research to illuminate the biological basis of health.
INTEREST GROUP SESSION—ORAL HEALTH: COGNITIVE FUNCTION, SOCIAL SUPPORT, AND ORAL HEALTH STATUS AMONG OLDER ADULTS IN THE U.S. AND ABROAD
Authors: Wu Bei , Shuman Stephen K , Saunders Michele 
Published: November 2019

Abstract
There is an increasing awareness of the importance of oral health and its associated risk factors among older adults. This symposium includes four papers that address cognitive function, social support and oral health problems and symptoms among older adults in the U.S. and China. Lu and his colleagues examined the reciprocal relationship between cognitive function and complete tooth loss Chinese adults age 50+ using the China Health and Retirement Longitudinal study. The results show that there is a reciprocal relationship between these two indicators. The second paper used the Population Study of Chinese Elderly in Chicago (PINE) and examined the associations between tooth/gums symptoms and changes in cognitive function in Chinese older immigrants. The results reveal that having teeth symptoms was associated with a decline in cognitive function. Using the same PINE data, the third paper examined the association between different characteristics of social relationships and the number of oral health problems among U.S. older Chinese adults. Wu and her colleagues conducted a partner-assisted pilot intervention to improve oral health for community-dwelling older adults with either mild cognitive impairment or mild dementia. The results of this 6-month intervention show that persons in the treatment group had more improvement in oral hygiene than those in the control group. Findings from these four papers illustrate that cognitive function, social support, and oral health are interrelated. This symposium highlights the importance of improving cognitive health, social support, and oral health for middle-aged and older adults.
LATENT CLASS ANALYSIS OF RE-EXPERIENCING VIOLENCE ACROSS THE LIFE COURSE
Authors: Kong Jooyoung , Easton Scott 
Published: November 2019

Abstract
Guided by the cumulative disadvantage hypothesis, the present study examines recurrent victimization experiences across the life course and their impact on psychological health in later life. Using data from the 2010-2011 Wisconsin Longitudinal Study, we explored the latent structure of histories of childhood maltreatment (i.e., neglect, emotional/physical abuse, witness of domestic violence) and elder abuse victimization among 5,968 older adults (average age of 71 years). We also investigated whether membership in specific latent classes, particularly experiencing both childhood and elder victimization, would be associated with psychological functioning in late life. We identified five latent classes: “Never victimized” (66% of respondents), “Abused as child” (16%), “Abused and neglected as child” (9%), “Abused as elder” (6%), and “Abused as child and elder” (2%). Also, the “abused as child and elder” class consistently was associated with negative psychological outcomes (i.e., distress and somatic symptom severity) and lower levels of psychological well-being.
LIFE COURSE PATHWAYS OF CHILDHOOD SOCIOECONOMIC STATUS TOWARD CLINICAL RISK FACTORS FOR WORSE KIDNEY FUNCTION
Authors: Surachman Agus , Santos Alexis , Rush Jonathan , Alexander Lacy , Coe Christopher , Almeida David M 
Published: November 2019

Abstract
This study examines the roles of daily stress processes as a possible mediator of how life course socioeconomic inequality is reproduced in day-to-day experiences and creates disparities in clinical risk for rapid kidney function declines in adulthood. Data are from 1174 middle and older adults (56% female; ages 40–84, Mage = 56.2) who participated in the MIDUS study wave 2 and Refresher. We found significant pathways that childhood SES was associated with education and adult SES, adult SES was associated with exposure to daily stressors and daily stressor reactivity to negative affect, positive affect, and somatic symptom. In turn, higher report of daily somatic symptom and lower report of daily positive affect were associated with higher CKD risk factors. Finally, childhood SES was directly associated with CKD risk factors. Childhood SES is associated with clinical risks for rapid kidney function decline through direct association and life course accumulation.
COMPARISON OF AGE AND BIOLOGICAL SEX MORTALITY TRENDS BETWEEN ADULTS WITH AND WITHOUT DOWN SYNDROME
Authors: Stevens James D , Stevens James D , Landes Scott D , Turk Margaret A 
Published: November 2019

Abstract
Distinct mortality trends emerge from comparisons of mean and median age at death and specific causes of death between adults with and without cerebral palsy. We compare standardized mortality odds ratios (SMORs) for 20 leading causes of death for 11,895 adults with cerebral palsy and 13,047,988 without cerebral palsy in the US between 2012 and 2016. Male and female decadents with cerebral palsy died significantly younger than male and female decadents without cerebral palsy, and were more likely to die from respiratory diseases, choking, and unknown causes. Public health and preventive care efforts should account for respiratory, swallowing, and nutrition risks, as well as mortality trends’ variation across age and biological sex. The CDC and WHO could better surveil this population’s health and mortality by disallowing certifiers from using cerebral palsy as the underlying cause of death as the practice leads to high rates of unknown causes of death.