bluuebunny/crossref_metadata_2025_split huggingface dataset:
The journey of special population to vaccination centers in Brazil: knowledge and perceptions
Authors: Petraglia Tânia Cristina de Mattos Barros , Spinardi Julia Regazzini , Almeida Rodrigo Sini de 
Published: February 2020

Abstract
Background: Vaccination is one of the most effective public health strategies to control and prevent diseases. The Brazilian National Immunization Program is an international reference of public healthcare policy. Since 1993 Reference Centers for Special Immunobiologicals (CRIE) were implemented in order to facilitate the access to immunobiologicals, especially for those with congenital or acquired immunodeficiencies and other special morbidity conditions, or subjects exposed to risk situations. To assess knowledge and perceptions concerning the relevance of special patients’ vaccination and the immunization centers (CRIE) structure from patients, physicians and CRIE professional perspectives.Methods: An opinion survey was carried out in 2018 from June to July, including patients, physicians and CRIE professionals. A structured questionnaire was applied in a single interview to each interest group through phone calls. All instruments contained questions on general information, individuals’ profile, and knowledge and perceptions concerning CRIE. Results were obtained from the compilation of each groups’ answers. Data analysis was carried out in a descriptive approach, through measures of central tendency and dispersion for continuous variables, and measures of frequency for categorical variables.Results: The sample was composed by 280 individuals: 135 physicians; 135 patients; and 10 CRIE professionals. Regarding physician’s perspective, most of them reported to know CRIE (79%) and to refer patients (64%), and agreeing that a good quality service with well-trained professionals is offered (91%). Patients reported to receive the recommendation for vaccination by attending physician (91%), and to have never experienced the unavailability of a vaccine (91%) at CRIE. Analysis from CRIE professional’s perspective showed that patients are most frequently referred to CRIE by infectologists (33%) and that vaccination campaigns have a huge influence on demand. However, they also reported that there is no disclosure about CRIE service for population and physicians.Conclusions: Physicians classify vaccination as extremely important and all patients reported to follow recommendation. About immunization centers, a great perception about the service provided by CRIE was reported, but there is still place for uptake the patient journey.
Feasibility investigation of uniportal video-assisted thoracoscopic anatomical lung resection for pulmonary sequestration
Authors: Sun Yungang , Shao Feng , Zhang Qiang , Wang Zhao 
Published: February 2020

Abstract
Background: Uniportal video-assisted thoracic surgery (UVATS) technique has been increasingly used for many thoracic diseases. Whether UVATS has equivalent or better perioperative outcomes for pulmonary sequestration (PS) patients remains controversial. Our study aimed to evaluate the feasibility of UVATS in anatomical lung resection for pulmonary sequestration. Methods: A total of 24 patients with PS including fifteen males and nine females with the mean age of 40 (rang, 18-65) years old, who had received completely UVATS anatomical lung resection for PS in Nanjing Chest Hospital between January 2016 and December 2018 were retrospectively reviewed. Related clinical data were retrieved from hospital records and analyzed. Results: All 24 patients had been treated with the UAVTS approach successfully without aberrant artery ruptured or massive hemorrhage, and no patients died during the perioperative period. Overall median surgery time was 102 mins (range, 55-150mins), the mean blood loss was 94 ml (range, 10-300ml), the mean days of chest tube maintained were 4 days (range,1-10days), and the mean postoperative hospitalization days was 6 days (range,2-11days). All patients were cured, without cough, fever, hemoptysis, and so on, associated with PS, occurring during the average follow-up of 17 months (range, 3-35months). Conclusions: Our preliminary results revealed that anatomical lung resection by UVATS is a safe and feasible mini-invasive technique for PS patients, which might be associated with less postoperative pain, reduced paresthesia, better cosmetic results, and faster recovery.
Plasma miR-181a as a Candidate Diagnostic Biomarker for Kawasaki Disease Patients with Coronary Artery lesions
Authors: Peng Yu , Liu Xiaohui , Duan Junkai , Duan Zhao , Zou Zheng , Liu Zhiqiang , Zhou Yulan 
Published: February 2020

Abstract
Background: Kawasaki disease (KD) is an acute and systemic vasculitis, and the critical complication in KD patients is coronary artery lesions (CAL). Plasma miR-181a was found dysregulated in a variety of cardiovascular disease. The aim of this study was to define the relationship between the plasma miR-181a levels and CAL in KD. Methods: Plasma miR-181a levels were analyzed by quantitative reverse transcriptase-polymerase chain reaction in 121 patients with KD. Results:We found that plasma miR-181a levels at the acute phase were significantly elevated in KD patients with CAL than those without CAL. Correlation analysis showed that plasma miR-181a levels were positively correlated with the concentrations of CRP (r=0.363, P < 0.05) and NT-proBNP (r=0.389, P < 0.05). Receiver operating characteristic curve analyses showed that plasma miR-181a was of significant prediction value for CAL in KD, the area under receiver operating characteristic curve value for plasma miR-181a in prediction of CAL was 0.747, and the estimated sensitivity and specificity were 75.0% and 68.8%, respectively. Conclusions: Plasma miR-181a is prone to be a candidate biomarker for predicting CAL in KD. Therefore, further investigations are warranted to fully elucidate its role in KD.
Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
Authors: Sonnet Friederike , Namork Ellen , Stylianou Eva , Gaare-Olstad Ingvild , Huse Kanutte , Andorf Sandra , Mjaaland Siri , Dirven Hubert , Nygaard Unni 
Published: February 2020

Abstract
Background: The underlying cellular mechanisms causing adverse reactions to food are complex and still not fully understood. Therefore, in this study we aimed to identify functional and/or phenotypical immune cell signatures characteristic for adult patients reporting adverse reactions to food.
By mass cytometry, we performed high-dimensional profiling of peripheral blood mononuclear cells (PBMC) from adult patients reporting adverse reactions to food and healthy controls. The patients were grouped according to sIgE-positive or sIgE-negative serology to common food and inhalant allergens. Two broad antibody panels were used, allowing determination of major immune cell populations in PBMC, as well as activation status, proliferation status, and cytokine expression patterns after PMA/ionomycin-stimulation on a single cell level.
Results: By use of data-driven algorithms, several cell populations were identified showing significantly different marker expression between the groups.
Most striking was an impaired frequency and function of polyfunctional CD4 + and CD8 + T cells in patients reporting adverse reactions to food compared to the controls. Further, subpopulations of monocytes, T cells, and B cells had increased expression of functional markers such as CD371, CD69, CD25, CD28, and/or HLA-DR as well as decreased expression of CD23 in the patients. Most of the differing cell subpopulations were similarly altered in the two subgroups of patients.
Conclusion: Our results suggest common immune cell features for both patient subgroups reporting adverse reactions to food, and provide a basis for further studies on mechanistic and diagnostic biomarker studies in food allergy.
A randommized, prospective, controlled trial of Glidscope®, C-MAC®(D) videolaryngoscope and Macintosh laryngoscope for double lumen endotracheal intubation in patients with predicted normal airways
Authors: Huang Ping , Zhou Renlong , Lu Zhixing , Hang Yannan , Wang Shanjuan , Huang zhenling 
Published: February 2020

Abstract
Background Double lumen endotracheal tube (DLT) is the most widely used method for lung isolation in current thoracic anesthesia practice. In recent years, the routine application of videolaryngoscope for tracheal intubation has gradually increased, but there are still few related reports. We doubted whether we could get benefits from applying the videolaryngoscope for double-lumen tracheal tube placement in patients with predicted normal airways. Therefore, this study was designed to compare the clinical performance of GlideScope ® , C-MAC ® (D) videolaryngoscope and Macintosh laryngoscope in DLT intubation. Methods 90 adult patients with no predictors for difficult airways were allocated randomly into three groups. All the patients were anesthsized by a routine anesthesia process with different laryngoscopes according to the result of allocation. We accessed DLT insertion time, first-pass success rate, numerical rating scale (NRS) of DLT delivery, NRS of DLT insertion and Cormack-Lehane degree(C/L degree). The hemodynamic change and the incidence of intubation complications were also recorded. Results Compared with GlideScope, Macintosh resulted in shorter time for DLT insertion (median:96(IQR:51[min-max:62–376]s v 73(26[48-419]s, p=0.003), but there was no difference between Macintosh and C-MAC(D) (p=0.610). As for the success at the first attempt, Macintosh was significantly associated with higher successful rate compared with GlideScope and C-MAC(D) (p=0.001, p=0.028, respectively). NRS of DLT delivery and NRS of DLT insertion were significantly lower in Macintosh group than others (p<0.001, respectively). However, C/L degree (I/II A /II B /III) in Macintosh group was statistically higher than others (p<0.001, respectively). The incidence of oral bleeding, hoarseness, sore throat and dental trauma were low in all groups (p>0.05, respectively). There were no statistical difference about DLT misplacement, fibreoptic time and hemodynamic changes among three groups. Conclusions GlideScope ® and C-MAC ® (D) videolaryngoscopes may not be recommended as the first choice for routine DLT intubation in patients with predicted normal airways.
Patient-specific instrument assisted calcaneal fracture minimally invasive internal fixation is accurate and practical: a retrospective study
Authors: Wang Chenggong , Xu Can , Li Mingqing , Li Hui , Xiao Han , Zhong Da , Liu Hua 
Published: February 2020

Abstract
Background: Almost all of the traditional calcaneal fracture minimally invasive internal fixation (MIIF) require a lot of intraoperative fluoroscopy, moreover, the fracture recovery of many patients are not considered ideal. Therefore, we designed a new surgical procedure through the digital surgical simulation and made patient-specific instrument (PSI) for calcaneal fracture patients before surgery, and then we manage the operation through the assistance of PSI during the whole process. The purpose of this study is to verify whether the PSI assisted calcaneal fracture minimally invasive internal fixation is accurate and practical. Methods: We retrospectively analyzed the Sanders type III or IV fresh calcaneal fracture patients who had been performed MIIF assisted by the PSI in our hospital during January 2016 to December 2018. We collected and analyzed perioperative data including intraoperative fluoroscopy times, whether the internal fixation actual usage (IFAU) same as preoperative plan, surgical time and situation of complication; and collected and analyzed the data of preoperative actual measurement, preoperative-plan and postoperative actual measurement from X-rays and CT, including Böhler angle, Gissane angle, subtalar joint width, calcaneus valgus angle and calcaneal volume overlapping ratio. All patients had been followed up and their AOFAS score had been recorded. Then we performed statistical analyses. Results: The intraoperative fluoroscopy times was 3.95±1.78, the condition of IFAU in 16 patients was the same as preoperative plan, the surgery time was 28.16±10.70 min, no patients developed complications. The preoperative plan Böhler angle, Gissane angle, subtalar joint width and calcaneus valgus angle were not significant different from the postoperative; the preoperative Böhler angle, Gissane angle, subtalar joint width and calcaneus valgus angle were all significant different from the postoperative. The calcaneal volume overlapping ratio with preoperative design was 91.2±2.3%. The AOFAS score of all patients gradually increased as time goes on, and difference of the AOFAS scores between all time-points were significant. Conclusions: The new PSI can indeed carry out the preoperative plan accurately and quickly, and the PSI assisted calcaneal fracture minimally invasive internal fixation is accurate and practical. Keywords: Digital surgical simulation; Patient-specific instrument; Calcaneal fracture; Minimally invasive internal fixation; Whole process-assisted surgical technique
A score of non-contrast transthoracic echocardiography to detect patent foramen ovale
Authors: Zhang Hui , Tang Haiyan , Wu Fei , Yu Chun , Dong Qiang , Cao Wenjie 
Published: February 2020

Abstract
Background: The aim of this study was to develop a screening score of non-contrast transthoracic echocardiography (TTE) for patent foramen ovale (PFO) in patients with embolic stroke of undetermined source (ESUS). Methods: We performed a retrospective analysis of 218 consecutive patients with a recent ESUS from 2015 to 2018, who received TTE and transcranial Doppler (TCD) as routine examinations. PFO was diagnosed by the bubble test of TCD. Significant differences of the TTE findings between PFO group and non-PFO group were selected into a score. Results: PFO was diagnosed in 35.8% (78/218) of the patients. Compared with non-PFO group, a larger median aortic root diameter (ARd) (34mm vs. 32mm, p=0.005), a lower median peak E wave velocity (Em) (61.5cm/s vs. 68cm/s, p=0.005) and a lower incidence rate of mitral regurgitation (33.8% vs. 50.7%, p=0.016) were seen in PFO group. A three-point score of TTE criteria (including aortic root diameter>33mm, Em<72cm/s and without mitral regurgitation, AEM) was tested to be independently predict PFO (odd risk 1.95, 95%CI 1.37~2.78, p<0.001). AEM score ≥2 detected PFO with a sensitivity of 0.71 (95% CI 0.67～0.85) and a specificity of 0.53 (95% CI 0.44 - 0.55). Conclusion: The AEM score measured with non-contrast TTE can select ESUS patients for bubble test of TCD to detect PFO.
Marine based Wireless Sensor Networks: Challenges and Requirements
Authors: Elgenaidi Walid , Newe Thomas 
Published: February 2020

Abstract
Marine environmental monitoring based on wireless sensor networks (WSN) is a challenging area of research due to the instability of the water field. Due to the characteristics of the water environment, there are certain considerations which must be taken into account before the establishment of marine based wireless sensor networks. These include the deployment of wireless nodes (WNs), energy consumption, network connectivity and security. This paper compares and contrasts the basic parameters relating to WSNs, while highlighting the main components necessary to form an ideal marine based WSN system, and some difficulties of implementing security in Marine WSNs such as the management of the cryptographic keys.
An Experimental Assessment of PZT Patches for Impedance-Based SHM Applications
Authors: Almeida Vinicius Augusto Dare de , Baptista Fabricio Guimarães 
Published: February 2020

AbstractIn this paper, we present an alternative method for assessing the sensitivity of lead zirconate titanate (PZT) piezoceramics for damage detection in structural health monitoring (SHM) systems based on the electromechanical impedance (EMI) principle. An assessment of the sensitivity is obtained experimentally using the pencil lead break (PLB) method, which is frequently used in acoustic emission (AE) systems. Tests were carried out on an aluminum beam, and the results show a clear relationship between the damage indices obtained from the electrical impedance signatures of the PZT patch bonded to the monitored structure and the power spectral density (PSD) obtained using the PLB method.
Development of thermostable FBG optical sensor for oil and gas applications
Authors: Snelders Dennis J. M. , Boersma Arjen 
Published: February 2020

Abstract
Important progress has been made towards the expanding of the limits of applicability of Fiber Bragg Grating optical sensors. The development of new thermostable coatings has opened up the possibility towards the use of this technology under extreme conditions, i.e. at high temperatures and pressures. The developed sensors have been tested for adsorption of a range of gaseous analytes and exhibit a sensitivity towards linear alkanes. Preliminary tests at high temperature in liquid phase indicate a high thermal stability.
Designing a Wireless Sensors Network for Monitoring and Predicting Droughts
Authors: Gaddam A , Al-Hrooby M , Esmael W F 
Published: February 2020

Abstract
Global warming and lack of rain were the main problems that caused increased drought around the world. In New Zealand, according to National Institute of Water and Atmospheric Research (NIWA) the drought in 2012 and 2013 was the worst drought in the last 70 years. Therefore, there is a need for technological intervention to monitor basic information about the weather and soil condition in order to identify and predict drought conditions. Initial experiments have shown that the proposed wireless sensor drought monitoring system is capable of remote real-time monitoring for extended periods. This monitoring can also help identify drought in the early stages and thereby indicate promptly when to take corrective measures. Intelligent sensors in a wireless network monitor the soil condition. These sensors collect various environmental; parameters and then send the pre-processed data wirelessly to a base station. From the base station this data uploads every two seconds to the cloud (internet) for further analysis. If a drought condition is identified by the monitoring system then an alert message is sent to the user via text message or email.
Analysis of precipitation variability over Satluj Basin, Himachal Pradesh, India: 1901–2013
Authors: Tirkey Nity , Parhi P. K. , Lohani A. K. , Chandniha S. K. 
Published: February 2020

Abstract
Himachal Pradesh is a mountainous state in the Indian Himalayas, which spreads over an area of 55,000 km2. The state has a unique geography, which influences the climatic variability of the state. In the present study, Satluj Basin has been considered as a study area. This basin experiences frequent floods, erratic distribution of rainfall and climatic variabilities, which causes extensive damage over the basin. Precipitation is one of the most crucial meteorological variables which determines the impact of climate change in the Himalayan landmass. For spatial and temporal variation of precipitation, long-term precipitation data of 113 years (1901–2013) was utilized. Further, non-parametric, i.e. Mann–Kendall (MK) and modified Mann–Kendall (MMK) tests, were performed to check possible trends and Sen's slope estimator (SSE) test was used for determining the change in magnitude over the basin at 95% level of significance. The entire analysis was performed on a monthly, annual and seasonal (pre-monsoon, monsoon, post-monsoon and winter) basis. In this study, it was noticed that both positive and negative trends are detected in monthly and seasonal time series. It was also noticed that similar results have been estimated in MK, MMK and Sen's slope estimator tests during 1901–2013.
Experimental investigation of impact of length and height of parallel skimming walls on controlling inlet sediment to lateral intake
Authors: Farshidnia Sadegh , Saneie Mojtaba , Hajikandi Hooman , Rostami Mohammad 
Published: February 2020

Abstract
Parallel skimming walls are regarded as one of most applicable methods for gaining a decline in the amount of sediment entering a lateral intake. The parallel skimming walls are installed on the main channel, in front of the intake span, creating a rotational flow and diverting sediments from the intake span, and as a result a reduction in the amount of sediment entry into the intake can be realized. The present paper aims at experimentally studying the impact of length (L) and height (H) of parallel skimming walls, as well as the effect of discharge shifts associated with the main channel on controlling the inlet sediment into the intake. First, the impact of parallel skimming walls incorporating three lengths (L = 60 cm, 75 cm, 90 cm) in front of the intake is investigated, then the impact of skimming walls incorporating three heights (H = 2 cm, 4 cm, 6 cm) is scrutinized. After each test, the sediment volume entry (V) into the intake was measured. By performing dimensional analysis, dimensionless ratios were obtained and the relation between the variables was determined. The results demonstrated that in the case of parallel skimming walls, the increase in L and H leads to mitigation in the amount of inlet sediment into the intake. Moreover, there is a proper agreement between the procedure of this study and the previous ones.
Surface-Engineered Cancer Nanomedicine: Rational Design and Recent Progress
Authors: Ahmad Javed , Ameeduzzafar  , Ahmad Mohammad Z. , Akhter Habban 
Published: February 2020

:
Cancer is highly heterogeneous in nature and characterized by abnormal, uncontrolled cells’ growth. It
is responsible for the second leading cause of death in the world. Nanotechnology is explored profoundly for sitespecific
delivery of cancer chemotherapeutics as well as overcome multidrug-resistance (MDR) challenges in
cancer. The progress in the design of various smart biocompatible materials (such as polymers, lipids and inorganic
materials) has now revolutionized the area of cancer research for the rational design of nanomedicine by
surface engineering with targeting ligands. The small tunable size and surface properties of nanomedicines provide
the opportunity of multiple payloads and multivalent-ligand targeting to achieve drug efficacy even in MDR
cancer. Furthermore, efforts are being carried out for the development of novel nano-pharmaceutical design,
focusing on the delivery of therapeutic and diagnostic agents simultaneously which is called theranostics to assess
the progress of therapy in cancer. This review aimed to discuss the physicochemical manipulation of cancer
nanomedicine for rational design and recent progress in the area of surface engineering of nanomedicines to improve
the efficacy of cancer chemotherapeutics in MDR cancer as well. Moreover, the problem of toxicity of the
advanced functional materials that are used in nanomedicines and are exploited to achieve drug targeting in cancer
is also addressed.