bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of High-Risk Left Ventricular Hypertrophy on Calcium Scoring Cardiac Computed Tomography Scans
Authors: Kay Fernando U. , Abbara Suhny , Joshi Parag H. , Garg Sonia , Khera Amit , Peshock Ronald M. 
Published: February 2020

Background:
Coronary artery calcium scoring only represents a small fraction of all information available in noncontrast cardiac computed tomography (CAC-CT). We hypothesized that an automated pipeline using radiomics and machine learning could identify phenotypic information about high-risk left ventricular hypertrophy (LVH) embedded in CAC-CT.

Methods:
This was a retrospective analysis of 1982 participants from the DHS (Dallas Heart Study) who underwent CAC-CT and cardiac magnetic resonance. Two hundred twenty-four participants with high-risk LVH were identified by cardiac magnetic resonance. We developed an automated adaptive atlas algorithm to segment the left ventricle on CAC-CT, extracting 107 radiomics features from the volume of interest. Four logistic regression models using different feature selection methods were built to predict high-risk LVH based on CAC-CT radiomics, sex, height, and body surface area in a random training subset of 1587 participants.

Results:
The respective areas under the receiver operating characteristics curves for the cluster-based model, the logistic regression model after exclusion of highly correlated features, and the penalized logistic regression models using least absolute shrinkage and selection operators with minimum or one SE λ values were 0.74 (95% CI, 0.67–0.82), 0.74 (95% CI, 0.67–0.81), 0.76 (95% CI, 0.69–0.83), and 0.73 (95% CI, 0.66–0.80) for detecting high-risk LVH in a distinct validation subset of 395 participants.

Conclusions:
Ventricular segmentation, radiomics features extraction, and machine learning can be used in a pipeline to automatically detect high-risk phenotypes of LVH in participants undergoing CAC-CT, without the need for additional imaging or radiation exposure.

Registration:

URL
http://www.clinicaltrials.gov
. Unique identifier: NCT00344903.
Multidimensional Voice Quality Evaluation After Transoral CO2 Laser Cordectomy: A Prospective Study
Authors: Hamzany Yaniv , Crevier-Buchman Lise , Lechien Jérôme R. , Bachar Gideon , Brasnu Daniel , Hans Stéphane 
Published: February 2020

Objective: To investigate voice quality changes of patients treated by transoral laser cordectomy (TLC) for early glottic cancer according to the type of cordectomies. Methods: A total of 164 consecutive male patients with an early glottic cancer were prospectively recruited from the Department of Otolaryngology—Head and Neck Surgery of the Georges Pompidou European Hospital. Depending on the tumor characteristics, patients benefited from type I to VI CO2 cordectomy regarding the European Laryngological Society classification. The following voice quality outcomes were pre- to postoperatively assessed: voice handicap index (VHI), perceptual grade of dysphonia, roughness, breathiness, maximum phonation time, and acoustic parameters. Results: Fifty-five patients with Tis, T1, or T2 vocal fold cancer completed the study (mean age: 61.7 years). Of these patients, 34 and 21 composed group 1 (types I-III TLC) and group 2 (types IV-VI TLC), respectively. Voice handicap index, grade of dysphonia, and breathiness significantly improved from pre- to 3- and 6-month posttreatment in group 1. In group 2, only VHI significantly improved from pre- to 3- and 6-month posttreatment. Acoustic and aerodynamic measurements did not change throughout the postoperative course. Patients with types I to III TLC exhibited better postoperative voice outcomes compared to those treated by types IV to VI TLC. Conclusion: Irrespective to the types of TLC, the subjective voice quality of patients treated by CO2 laser cordectomy for early glottic cancer significantly improved from pre- to 3- and 6-month posttreatment. The usefulness of aerodynamic and acoustic measurements as postoperative outcomes of voice quality changes remain controversial and require future studies considering multidimensional assessment of voice.
Prevalence of human papillomavirus in archival head and neck cancer in the eastern Inner Mongolian Autonomous Region, China
Authors: Wu Enqi , An Guangwen , Wu Ritu , Tang Yuanyu , Li Qing , Wang Jinhua , Ling Yaqin , You Jia 
Published: February 2020

Objective: To investigate the prevalence of human papillomavirus (HPV) in archival head and neck cancer (HNC) collected from the Tong-Liao area, which is located in east Inner Mongolia, China. Methods: The presence of HPV in 54 HNCs and 25 benign biopsies was detected and the sequence variation of the E6 gene in HPV-positive samples was analyzed to determine their lineage/sublineage classification. Results: HPV was detected in only 4 out of 54 HNCs and no benign biopsies were found to be HPV-positive. After further p16INK4a immunostaining, only 3 cases of HNC were positive for both HPV and p16INK4a. Phylogenetic analysis of the isolated E6 gene shows that the HPV 16, HPV 31, and HPV 58 isolated in this study belong to lineage A. Conclusions: The prevalence of HPV in HNC from this area is very low. The lineage/sublineage classification of the 3 HPV types in HNC in this area is consistent with the previous reported data of HPV lineage distribution in cervical cancer within China.
Characteristics of Neuropeptide-Containing Innervation, Tissue Remodeling, Growth, and Vascularity in Noses of Patients With Cleft Lip and Palate
Authors: Balode Evija , Pilmane Mara 
Published: February 2020

Objective: To detect the appearance and distribution of factors regulating remodeling, innervation, growth, and vascularity of the nasal tissue affected by cleft lip and palate (CLP). Design: Morphological analysis of human tissue. Setting: Cleft and craniofacial center. Participants: Fifteen patients who underwent CLP rhinoplasty, 7 control patients. Interventions: Rhinoplasty. Main Outcome Measures: Immunohistochemistry was performed with protein gene product (PGP) 9.5, transforming growth factor β1 (TGFβ1), vascular endothelial growth factor (VEGF), cluster of differentiation 34 (CD34), matrix metalloproteinase 2 (MMP2), MMP9, and tissue inhibitor of metalloproteinase 2 (TIMP2). The results were evaluated semiquantitatively. Spearman rank order correlation coefficient and Mann-Whitney U test were used for statistical analysis. Results: Cleft lip and palate–affected tissue revealed dense and loose connective tissue, adipose cells, and hyaline cartilage, along with numerous CD34-positive endotheliocytes and regions of VEGF-positive neoangiogenesis. We observed moderate to numerous PGP 9.5-positive nerve fibers. Transforming growth factor β1, MMP2, MMP9, and TIMP2 were found in cartilage and connective tissue. Cleft lip and palate–affected tissue compared to control samples showed a statistically significant difference in PGP 9.5 ( P = .006), VEGF ( P = .001), MMP2 ( P = .002), MMP9 ( P = .013), and TIMP2 ( P < .001) expression. We observed a strong, positive correlation between VEGF and MMP9 ( P = .027; r S = 0.705). Conclusions: The moderate expression of TGFβ1 and increased distribution of VEGF, MMP2, MMP9, and TIMP2 demonstrate an active extracellular matrix remodeling and angiogenesis, performed by proteases. The cartilaginous septum of the nose is an example of balance between tissue degradation and its suppression, demonstrated by the relationship between MMPs and TIMPs and the presence of VEGF.
Intimate Partner Violence (IPV) Against HIV-Positive Women in Sub-Saharan Africa: A Mixed-Method Systematic Review and Meta-Analysis
Authors: Tenkorang Eric Y. , Asamoah-Boaheng Michael , Owusu Adobea Y. 
Published: February 2020

Objectives: To systematically analyze and summarize the literature on intimate partner violence (IPV) against HIV-positive women in sub-Saharan Africa (SSA) and to identify their risk factors for IPV. Method: A comprehensive review of the literature using the Preferred Reporting Item for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analyses of Observational Studies in Epidemiology (MOOSE) yielded 1,879 articles (PubMed = 1,251, Embase = 491, Web of Science = 132, and identified additional records = 5). Twenty were selected for quantitative and qualitative assessment and synthesis. We employed a random effects model with generic inverse variance method and estimated the odds ratios. Findings: Results indicated a high prevalence of physical, sexual, and emotional violence against women living with HIV/AIDS in SSA. Educational background, alcohol use, marital status, previous experiences with IPV, and employment status were identified as significant risk factors. We also assessed the methodological quality of the articles by examining publication bias and some heterogeneity statistics. Conclusion: There is limited research on IPV against HIV-positive women in SSA. However, the few existing studies agree on the importance of targeting HIV-positive women with specific interventions given their vulnerability to IPV and to address factors exacerbating these risks and vulnerabilities.
Mortality After Paclitaxel-Coated Device Use in Patients With Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Dinh Krystal , Gomes Miguel Lemos , Thomas Shannon D. , Paravastu Sharath C.V. , Holden Andrew , Schneider Peter A. , Varcoe Ramon L. 
Published: February 2020

Purpose: To report the risk of all-cause mortality after treatment with paclitaxel-coated devices vs uncoated controls in patients with chronic limb-threatening ischemia (CLTI). Materials and Methods: A search of the PubMed, Embase, Cochrane, CINAHL, DARE, and PROSPERO databases was made on 5 November 2019 to identify randomized controlled trials (RCT) using intention-to-treat analysis to compare a paclitaxel-coated device to an uncoated device in PAD patients having clinical follow-up of at least 6 months. Half of the study population had to have CLTI or extractable data on the CLTI subgroup if <50%. The search identified 11 trials having 1450 patients randomized to a paclitaxel-coated device (n=866) or an uncoated control (n=584). There were 1367 (94.3%) patients with CLTI (range 10–429). The single endpoint was all-cause mortality, which was analyzed by pooling the mortality data in a DerSimonian and Laird random effects model. Summary statistics are expressed as relative risk ratios (RR) with a 95% confidence interval (CI). Results: The mean follow-up was 25.6 months (range 6–60); 10 of 11 studies reported a minimum 12-month follow-up. There were 161 (18.6%) deaths among 866 subjects in the paclitaxel device group and 116 deaths among 584 (19.9%) subjects in the non-coated control group (RR 0.93, 95% CI 0.78 to 1.12, p=0.45). Conclusion: There was no observed difference in short- to midterm mortality among a pooled patient population of predominately CLTI patients treated with paclitaxel-coated balloons or stents compared with uncoated controls.
Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival
Authors: Sanchis Juan , Valero Ernesto , García Blas Sergio , Barba Esther , Pernias Vicente , Miñana Gema , Brasó José , Fernandez-Cisnal Agustín , Gonzalez Jessika , Noceda José , Carratalá Arturo , Chorro Francisco J , Núñez Julio , Pickering John W 
Published: February 2020

Background
Undetectable high-sensitivity cardiac troponin (hs-cTn) in a single determination upon admission may rule out acute coronary syndrome. We investigated undetectable hs-cTnT (&lt;detection limit; &lt;5 ng/l) together with clinical risk scores (GRACE, TIMI, HEART and a previously published simple score), for one-year outcomes in patients with chest pain and normal hs-cTnT (&lt;99th percentile; &lt;14 ng/l) upon admission.

Methods
This study was a retrospective design involving 2254 consecutive patients (July 2016–November 2017). The primary endpoint was one-year death or acute myocardial infarction; the secondary endpoint added unstable angina requiring revascularization. Early (&lt;90 minutes since pain onset, n = 661) and late (n = 1593) presenters were separately considered.

Results
A total of 56 (2.5%) patients reached the primary endpoint and 91 (4%) the secondary endpoint. Undetectable hs-cTnT had a poor C-statistic in early and late presenters (0.648 and 0.703, respectively). Adding hs-cTnT measurable concentrations above the detection limit (as continuous variable) significantly enhanced the C-statistics (0.754 and 0.847, respectively). Addition of the HEART (0.809, p = 0.005) or simple clinical scores (0.804, p = 0.02) further improved the model and significantly reclassified patient risk, in early presenters. The results were similar for the secondary endpoint. The TIMI risk score performed worse and the GRACE score did not give additional information. In late presenters, no clinical score provided significant additional information over hs-cTnT.

Conclusions
Diagnostic algorithms should consider not only whether hs-cTnT is above or below the detection limit but also its concentration if above, for risk stratification over one year in patients with initial normal hs-cTnT. The clinical scores provide valuable additional information in early presenters.
York University and Cupe 3903— Future of Collective Bargaining Rights
Authors: Mehrotra Sonia , Risavy Stephen D. 
Published: February 2020

The Canadian Union of Public Employees (CUPE) 3903 view the introduction of the new Ontario government’s ‘back to work’ legislation (Bill 2) as detrimental and a threat to their fundamental bargaining rights. Why is the government legislating the CUPE members back to work instead of allowing them to further negotiate with the administration of York University? If resolving issues through the collective bargaining process is not allowed, then what will happen to the relationship between the union and the university authorities? Dilemma Why did the government bring in the bill with ‘back to work’ clause? The concerned parties could have settled the issue through negotiation. Theory: Labour relations, integrative vs. distributive negotiation and third-party interventions Type of the case: Decisional and applied Protagonist: Not needed Options Negotiation, appointing mediator, adopting competitive distributive strategy or collaborative integrative strategy Discussions and Case Questions Suggest a more effective way to resolve the crisis. What are the main contentions of CUPE 3903 and the York University Administration in this negotiation? Discuss the strategies and tactics as used by CUPE 3903 and the York University Administration. Could these be optimized further? Evaluate the gap between the current strategy and the optimal one Is there any way in which a third-party mediator could craft a mutually beneficial agreement?
Effect of leg dominance on early functional outcomes and return to sports after anterior cruciate ligament reconstruction
Authors: Boo HC , Howe TS , Koh Joyce SB 
Published: February 2020

Introduction: The effect of leg dominance on anterior cruciate ligament (ACL) injuries has been studied with some studies noting a propensity for injuries in the non-dominant leg. Its effect on post-ACL reconstruction recovery, however, is not well known. The authors hypothesize that dominant limb injuries undergo rehabilitation faster and positively affect early functional outcome scores and return to sports and set about studying these effects. Methods: This is a retrospective study of 254 patients from a single institution who underwent ACL reconstruction for acute ACL ruptures and the results were compared between patients with dominant and non-dominant limb injuries. Objective measurements including the KT-1000, single-leg hop distance and Biodex knee extension peak torque were used to evaluate recovery. Pre- and post-operative functional outcome scores such as the International Knee Documentation Committee (IKDC), Tegner activity score and Lysholm knee scale were documented. Results: Early functional outcomes were similar. Minimal clinically important difference (MCID) improvement in IKDC scores was achieved in 69.7% of the dominant versus 66.0% of the non-dominant injury group ( p = 0.99), 75.2% versus 79.6% ( p = 0.45) for the Lysholm knee scale, and 81.6% versus 84.9% ( p = 0.50) for the Tegner activity score. The majority of patients in both subgroups had a return of at least 80% of peak knee flexion and extension peak torque at 5.4 months post-operatively; 92.9% of subjects with a non-dominant leg injury and 87.2% with a dominant leg injury had returned to their pre-injury sports 1 year from surgery. Conclusions: Results from this study suggest that despite theoretical differences, leg dominance does not have a significant impact on short-term functional outcomes and return to sports. Objective measurements suggest that limb strength recovers at a comparable rate. Injuries to either leg demonstrate equally positive improvement post-ACL reconstruction given the same post-operative rehabilitation. Level of Evidence: III, retrospective comparative study. Level of Evidence: III, retrospective cohort study.
International Olympic Committee Consensus Statement: Methods for Recording and Reporting of Epidemiological Data on Injury and Illness in Sports 2020 (Including the STROBE Extension for Sports Injury and Illness Surveillance (STROBE-SIIS))
Authors:   International Olympic Committee Injury and Illness Epidemiology Consensus Group, Bahr Roald , Clarsen Ben , Derman Wayne , Dvorak Jiri , Emery Carolyn A. , Finch Caroline F. , Hägglund Martin , Junge Astrid , Kemp Simon , Khan Karim M. , Marshall Stephen W. , Meeuwisse Willem , Mountjoy Margo , Orchard John W. , Pluim Babette , Quarrie Kenneth L. , Reider Bruce , Schwellnus Martin , Soligard Torbjørn , Stokes Keith A. , Timpka Toomas , Verhagen Evert , Bindra Abhinav , Budgett Richard , Engebretsen Lars , Erdener Uğur , Chamari Karim 
Published: February 2020

Background: Injury and illness surveillance, and epidemiological studies, are fundamental elements of concerted efforts to protect the health of the athlete. To encourage consistency in the definitions and methodology used, and to enable data across studies to be compared, research groups have published 11 sport- or setting-specific consensus statements on sports injury (and, eventually, illnesses) epidemiology to date. Objective: To further strengthen consistency in data collection, injury definitions, and research reporting through an updated set of recommendations for sports injury and illness studies, including a new Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist extension. Study Design: Consensus statement of the International Olympic Committee (IOC). Methods: The IOC invited a working group of international experts to review relevant literature and provide recommendations. The procedure included an open online survey, several stages of text drafting and consultation by working groups, and a 3-day consensus meeting in October 2019. Results: This statement includes recommendations for data collection and research reporting covering key components: defining and classifying health problems, severity of health problems, capturing and reporting athlete exposure, expressing risk, burden of health problems, study population characteristics, and data collection methods. Based on these, we also developed a new reporting guideline as a STROBE extension—the STROBE Sports Injury and Illness Surveillance (STROBE-SIIS). Conclusion: The IOC encourages ongoing in- and out-of-competition surveillance programs and studies to describe injury and illness trends and patterns, understand their causes, and develop measures to protect the health of the athlete. The implementation of the methods outlined in this statement will advance consistency in data collection and research reporting.
Association of wood use in bedrooms with comfort and sleep among workers in Japan: a cross-sectional analysis of the SLeep Epidemiology Project at the University of Tsukuba (SLEPT) study
Authors: Morita Emi , Yanagisawa Masashi , Ishihara Asuka , Matsumoto Sumire , Suzuki Chihiro , Ikeda Yu , Ishitsuka Mami , Hori Daisuke , Doki Shotaro , Oi Yuichi , Sasahara Shinichiro , Matsuzaki Ichiyo , Satoh Makoto 
Published: February 2020

AbstractSeveral priority characteristics of wood that have beneficial effects on human beings have been reported. However, the advantages of wood use in bedroom interiors for sleep have not been fully evaluated. The aim of this cross-sectional epidemiological study was to evaluate the association of wood use in housing and bedrooms with comfort in the bedroom and sleep among workers in Japan. The study methods included sleep measurements using actigraphy and a self-administered questionnaire survey. In total, 671 workers (298 men and 373 women; mean age ± standard deviation: 43.3 ± 11.2 years) were included in the analysis. The amount of wood used in bedrooms was significantly associated with comfort in bedrooms, inversely associated with suspicion of insomnia, partly inversely associated with self-rated poor sleep quality, but not associated with low sleep efficiency. On logistic regression analysis, the adjusted odds ratio (aOR) of the “large amount of wood” group relative to the “no wood” group was 3.25 [95% confidence interval (CI) 1.63–6.47] for comfort. The aOR of the “no wood” group relative to the “large amount of wood” group was 2.15 (95% CI 1.11–4.16) for suspicion of insomnia. Wood structure of housing, as well as wood use on either the floor, wall, or ceiling, were not significantly associated with comfort and sleep conditions. Our study suggested that the use of a large amount of wood used in the bedroom interior could be beneficial for comfort, sleep, and therefore, health of workers. Further studies are required to obtain generalizable results.
Three-Dimensional CuO/TiO2 Hybrid Nanorod Arrays Prepared by Electrodeposition in AAO Membranes as an Excellent Fenton-Like Photocatalyst for Dye Degradation
Authors: Date Manisha Kondiba , Yang Li-Heng , Yang Tzu-Yi , Wang Kuang-ye , Su Teng-Yu , Wu Ding-Chou , Cheuh Yu-Lun 
Published: February 2020

AbstractThree-dimensional (3D) CuO/TiO2 hybrid heterostructure nanorod arrays (NRs) with noble-metal-free composition, fabricated by template-assisted low-cost processes, were used as the photo-Fenton-like catalyst for dye degradation. Here, CuO NRs were deposited into anodic aluminum oxide templates by electrodeposition method annealed at various temperatures, followed by deposition of TiO2 thin films through E-gun evaporation, resulting in the formation of CuO/TiO2 p-n heterojunction. The distribution of elements and compositions of the CuO/TiO2 p-n heterojunction were analyzed by EDS mapping and EELS profiles, respectively. In the presence of H2O2, CuO/TiO2 hybrid structure performed more efficiently than CuO NRs for Rhodamine B degradation under the irradiation of 500-W mercury-xenon arc lamp. This study demonstrated the effect of length of CuO NRs, on the photo-degradation performance of CuO NRs as well as CuO/TiO2 heterostructure. The optimized CuO/TiO2 hybrid NR array structure exhibited the highest photo-degradation activity, and the mechanism and role of photo-Fenton acting as the catalyst in photo-degradation of dye was also investigated.