bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximum power point optimization for a grid synchronized PV system considering partial shaded condition using multi-objective function
Authors: P Sathyanarayana , Ballal Rajkiran , Kumar Girish , S Shaileshwari 
Published: December 2019

Energy demand taking a bigger leap day by day, Renewable energy gets the most leading importance in catering the purpose. Solar being the abundantly available renewable energy resource solar panels are key components in harnessing solar energy. Solar energy is the most dependable and cheap energy in renewable sector. But harnessing solar energy with partial shading makes it difficult for simple tracking algorithm because of multiple power peak points. Settling time of DC link voltage during the dynamics in the load and the irradiation also plays a major role in power delivered to the grid . Highly dynamic situation aware processors have been in the verge for many applications where large amount of online processing is a need like the smart grid, which needs a faster online reacting time. This paper deals with such an online reacting Maximum Power Point Optimization (MPPO) on a PV system with Partial shaded condition (PSC). The MPPO uses the recent non-parametric optimization techniques like Particle Swarm Optimization (PSO) for maximizing the power delivered from the solar panel. This optimization is achieved by populating the duty cycle and K<sub>p</sub> and K<sub>i</sub> parameters of PI controller given to the DC-DC converter connected to the PV arrays for the stable supply to the grid. While applying the maximization algorithm for the solar power output from the PV arrays the PSC conditions are considered in order to make the control technique more robust. This paper deals with minimization of DC link voltage settling time and maximization of power in multi-objective,. MATLAB based simulation is carried and the comparative inference is produced in this paper. The simulation is developed for the 2.5kW PV array with the proposed method. The simulation carried out had performed better with the proposed method than the single objective method.Satisfactory results were observed both in the simulation of the proposed algorithm.
Performance analyses on fluidized bed dryer integrated biomass furnace with and without air preheater for paddy drying
Authors: Yahya M , Fahmi Hendriwan , Hadi Syafrul , Edison Edison 
Published: December 2019

The performance of a fluidized bed dryer integrated biomass furnace with air preheater (FBD with APH) and a fluidized bed dryer integrated biomass furnace without air preheater (FBD without APH) for drying of paddy have been evaluated. The FBD with APH and FBD without APH decreased the moisture of paddy from 24% (wet basis) to 14% (wet basis) within 43 and 47 minutes with average temperatures and relative humidities of 59.58 <sup>o</sup>C and 59.14<sup>o</sup>C, and 18.81% and 18.68%, respectively. The drying rate of paddy varied in the range of 0.11 kg/min-0.32 kg/min and 0.10 kg/min- 0.30 kg/min for FBD with APH and FBD without APH, with average values of 0.18kg/min and 0.17kg/min, respectively. The minimum, maximum, and average value speciﬁc moisture evaporation rate (SMER) was 0.20 kg/kWh, 0.57 kg/kWh, and 0.31 kg/kWh, respectively for FBD with APH, as well as 0.149 kg/kWh, 0.448 kg/kWh, and 0.252 kg/kWh, respectively, for FBD without APH. The specific energy consumption (SEC), the specific electrical energy consumption (SEEC), and the specific thermal energy consumption (STEC) were varied from 1.749 kWh/kg to 5.076 kWh/kg, 0.090 kWh/kg to 2.872 kWh/kg, and 0.760 kWh/kg to 2.204 kWh/kg, with average values of 3.528 kWh/kg, 1.96 kWh/kg, and 1.532 kWh/kg, respectively for FBD with APH, as well as from 2.234 kWh/kg to 6.702 kWh/kg, 1.056 kWh/kg to 3.167 kWh/kg, and 1.179 kWh/kg to 3.536 kWh/kg, with average values of 4.391 kWh/kg, 2.075 kWh/kg, and 2.316 kWh/kg, respectively, for FBD without APH. The thermal efﬁciencies of the FBD with APH and FBD without APH were varied between 12.4% and 37.93%, and 9.78% and 29.82%, resvectively, with average values of 20.78% and 16.61%. The thermal efficiency of FBD with APH was higher compared to FBD without APH.
R&D of Photovoltaic Thermal (PVT) Systems: an Overview
Authors: Fudholi Ahmad , Sopian Kamaruzzaman 
Published: December 2019

<span>Photovoltaic thermal (PVT), which is the popular technology for harvesting solar energy, receive solar energy and convert it into electrical and thermal energy simultaneously. In this review, design, heat transfer, energy modelling and performance analysis of PVT systems are presented. Four types of PVT systems base on heat transfer medium; air-based PVT system, water-based PVT system, the combination of water/air-based PVT system, and nanofluid-based PVT system are presented. In addition, major finding on energy and exergy analysis of PVT systems are summarized. </span>
Renal Dopamine Oxidation and Inflammation in High Salt Fed Rats
Authors: Banday Anees A. , Lokhandwala Mustafa F. 
Published: December 2019

Background
Oxidative stress and high salt intake could be independent or intertwined risk factors in the origin of hypertension. Kidneys are the major organ to regulate sodium homeostasis and blood pressure and the renal dopamine system plays a pivotal role in sodium regulation during sodium replete conditions. Oxidative stress has been implicated in renal dopamine dysfunction and development of hypertension, especially in salt‐sensitive animal models. Here we show the nexus between high salt intake and oxidative stress causing renal tubular dopamine oxidation, which leads to mitochondrial and lysosomal dysfunction and subsequently causes renal inflammation and hypertension.

Methods and Results

Male Sprague Dawley rats were divided into the following groups, vehicle (V)—tap water, high salt (
HS
)—1% NaCl, L‐buthionine‐sulfoximine (
BSO
), a prooxidant, and
HS
plus
BSO
without and with antioxidant resveratrol (R) for 6 weeks. Oxidative stress was significantly higher in
BSO
and
HS
+
BSO
–treated rat compared with vehicle; however, blood pressure was markedly higher in the
HS
+
BSO
group whereas an increase in blood pressure in the
BSO
group was modest.
HS
+
BSO
–treated rats had significant renal dopamine oxidation, lysosomal and mitochondrial dysfunction, and increased renal inflammation; however,
HS
alone had no impact on organelle function or inflammation. Resveratrol prevented oxidative stress, dopamine oxidation, organelle dysfunction, inflammation, and hypertension in
BSO
and
HS
+
BSO
rats.

Conclusions
These data suggest that dopamine oxidation, especially during increased sodium intake and oxidative milieu, leads to lysosomal and mitochondrial dysfunction and renal inflammation with subsequent increase in blood pressure. Resveratrol, while preventing oxidative stress, protects renal function and mitigates hypertension.
Testicular expression of long non–coding RNAs is affected by curative GnRHa treatment of cryptorchidism
Authors: Hadziselimovic Faruk , Verkauskas Gilvydas , Vincel Beata , Stadler Michael B. 
Published: December 2019

Abstract
Background
Cryptorchidism is a frequent endocrinopathy in boys that has been associated with an increased risk of developing testicular cancer and infertility. The condition is curable by combined surgery and hormonal treatment during early pre-pubertal stages using gonadotropin releasing hormone agonist (GnRHa). However, whether the treatment also alters the expression of testicular long non-coding RNAs (lncRNAs) is unknown. To gain insight into the effect of GnRHa on testicular lncRNA levels, we re-analyzed an expression dataset generated from testicular biopsies obtained during orchidopexy for bilateral cryptorchidism.

Results
We identified EGFR-AS1, Linc-ROR, LINC00221, LINC00261, LINC00282, LINC00293, LINC00303, LINC00898, LINC00994, LINC01121, LINC01553, and MTOR-AS1 as potentially relevant for the stimulation of cell proliferation mediated by GnRHa based on their direct or indirect association with rapidly dividing cells in normal and pathological tissues. Surgery alone failed to alter the expression of these transcripts.

Conclusion
Given that lncRNAs can cooperate with chromatin-modifying enzymes to promote epigenetic regulation of genes, GnRHa treatment may act as a surrogate for mini-puberty by triggering the differentiation of Ad spermatogonia via lncRNA-mediated epigenetic effects. Our work provides additional molecular evidence that infertility and azoospermia in cryptorchidism, resulting from defective mini-puberty cannot be cured with successful orchidopexy alone.
Evolving knowledge graph similarity for supervised learning in complex biomedical domains
Authors: Sousa Rita T. , Silva Sara , Pesquita Catia 
Published: January 2020

Abstract
Background
In recent years, biomedical ontologies have become important for describing existing biological knowledge in the form of knowledge graphs. Data mining approaches that work with knowledge graphs have been proposed, but they are based on vector representations that do not capture the full underlying semantics. An alternative is to use machine learning approaches that explore semantic similarity. However, since ontologies can model multiple perspectives, semantic similarity computations for a given learning task need to be fine-tuned to account for this. Obtaining the best combination of semantic similarity aspects for each learning task is not trivial and typically depends on expert knowledge.

Results
We have developed a novel approach, evoKGsim, that applies Genetic Programming over a set of semantic similarity features, each based on a semantic aspect of the data, to obtain the best combination for a given supervised learning task. The approach was evaluated on several benchmark datasets for protein-protein interaction prediction using the Gene Ontology as the knowledge graph to support semantic similarity, and it outperformed competing strategies, including manually selected combinations of semantic aspects emulating expert knowledge. evoKGsim was also able to learn species-agnostic models with different combinations of species for training and testing, effectively addressing the limitations of predicting protein-protein interactions for species with fewer known interactions.

Conclusions
evoKGsim can overcome one of the limitations in knowledge graph-based semantic similarity applications: the need to expertly select which aspects should be taken into account for a given application. Applying this methodology to protein-protein interaction prediction proved successful, paving the way to broader applications.
Copy number variation of CCL3L1 among three major ethnic groups in Malaysia
Authors: Jamaluddin Jalilah , Mohd Khair Nur Khairina , Vinodamaney Shameni Devi , Othman Zulkefley , Abubakar Suhaili 
Published: January 2020

Abstract
Background
C-C motif Chemokine Ligand 3 Like 1 (CCL3L1) is a multiallelic copy number variable, which plays a crucial role in immunoregulatory and hosts defense through the production of macrophage inflammatory protein (MIP)-1α. Variable range of the CCL3L1 copies from 0 to 14 copies have been documented in several different populations. However, there is still lack of report on the range of CCL3L1 copy number exclusively among Malaysians who are a multi-ethnic population. Thus, this study aims to extensively examine the distribution of CCL3L1 copy number in the three major populations from Malaysia namely Malay, Chinese and Indian. A diploid copy number of CCL3L1 for 393 Malaysians (Malay = 178, Indian = 90, and Chinese = 125) was quantified using Paralogue Ratio Tests (PRTs) and then validated with microsatellites analysis.

Results
To our knowledge, this is the first report on the CCL3L1 copy number that has been attempted among Malaysians and the Chinese ethnic group exhibits a diverse pattern of CCL3L1 distribution copy number from the Malay and Indian (p < 0.0001). The CCL3L1 ranged from 0 to 8 copies for both the Malay and Indian ethnic groups while 0 to 10 copies for the Chinese ethnic. Consequently, the CCL3L1 copy number among major ethnic groups in the Malaysian population is found to be significantly varied when compared to the European population (p < 0.0001). The mean/median reported for the Malay, Chinese, Indian, and European are 2.759/2.869, 3.453/3.290, 2.437/1.970 and 2.001/1.940 respectively.

Conclusion
This study reveals the existence of genetic variation of CCL3L1 in the Malaysian population, and suggests by examining genetic diversity on the ethnicity, and specific geographical region could help in reconstructing human evolutionary history and for the prediction of disease risk related to the CCL3L1 copy number.
Novel genomic resources for shelled pteropods: a draft genome and target capture probes for Limacina bulimoides, tested for cross-species relevance
Authors: Choo Le Qin , Bal Thijs M. P. , Choquet Marvin , Smolina Irina , Ramos-Silva Paula , Marlétaz Ferdinand , Kopp Martina , Hoarau Galice , Peijnenburg Katja T. C. A. 
Published: January 2020

AbstractBackgroundPteropods are planktonic gastropods that are considered as bio-indicators to monitor impacts of ocean acidification on marine ecosystems. In order to gain insight into their adaptive potential to future environmental changes, it is critical to use adequate molecular tools to delimit species and population boundaries and to assess their genetic connectivity. We developed a set of target capture probes to investigate genetic variation across their large-sized genome using a population genomics approach. Target capture is less limited by DNA amount and quality than other genome-reduced representation protocols, and has the potential for application on closely related species based on probes designed from one species.ResultsWe generated the first draft genome of a pteropod,Limacina bulimoides, resulting in a fragmented assembly of 2.9 Gbp. Using this assembly and a transcriptome as a reference, we designed a set of 2899 genome-wide target capture probes forL. bulimoides. The set of probes includes 2812 single copy nuclear targets, the 28S rDNA sequence, ten mitochondrial genes, 35 candidate biomineralisation genes, and 41 non-coding regions. The capture reaction performed with these probes was highly efficient with 97% of the targets recovered on the focal species. A total of 137,938 single nucleotide polymorphism markers were obtained from the captured sequences across a test panel of nine individuals. The probes set was also tested on four related species:L. trochiformis,L. lesueurii,L. helicina, andHeliconoides inflatus, showing an exponential decrease in capture efficiency with increased genetic distance from the focal species. Sixty-two targets were sufficiently conserved to be recovered consistently across all five species.ConclusionThe target capture protocol used in this study was effective in capturing genome-wide variation in the focal speciesL. bulimoides, suitable for population genomic analyses, while providing insights into conserved genomic regions in related species. The present study provides new genomic resources for pteropods and supports the use of target capture-based protocols to efficiently characterise genomic variation in small non-model organisms with large genomes.
Septic pulmonary embolism in China: clinical features and analysis of prognostic factors for mortality in 98 cases
Authors: Jiang Jing , Liang Qiu-li , Liu Li-hua , Cai Shuang-qi , Du Zhong-ye , Kong Jin-liang , Chen Yi-qiang 
Published: December 2019

Abstract
Background
To investigate the clinical features of septic pulmonary embolism (SPE) cases and prognostic factors for in-hospital mortality in China.

Methods
A retrospective analysis was conducted of SPE patients hospitalized between January 2007 and June 2018 in the Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University.

Results
A total of 98 patients with SPE were identified. All patients had bilateral multiple peripheral nodules on chest computed tomography. The most common pathogen found in blood culture was Staphylococcus aureus (10/33, 30.3%). Transthoracic echocardiography was performed in 39 patients and 20 showed vegetations. Bronchoscopy was performed in 24 patients. Bronchoalveolar lavage fluid (BALF) was obtained from 15 patients (62.5%) and showed predominantly polymorphonuclear cell infiltration (52%, range of 48%~ 63%). Four patients received transbronchial lung biopsy, and histopathological examinations revealed suppurative pneumonia and organizing pneumonia. The in-hospital mortality rate was 19.4%. Age (odds ratio [OR] 1.100; 95% confidence interval [CI] 1.035–1.169), hypotension (OR 7.260; 95% CI 1.126–46.804) and ineffective or delay of empirical antimicrobial therapy (OR 7.341; 95% CI 1.145–47.045) were found to be independent risk factors for in-hospital mortality, whereas drainage treatment was found to be a protective factor (OR 0.33; 95% CI 0.002–0.677).

Conclusions
SPE cases presented with nonspecific clinical manifestations and radiologic features. Blood cultures and bronchoscopy are important measures for early diagnosis and differential diagnosis. There is relationship between primary infection sites and the type of pathogen. Maintaining normal blood pressure and providing timely and appropriate initial antimicrobial therapy for effective control of the infection could improve prognosis.
Treatment patterns and sequences of pharmacotherapy for patients diagnosed with depression in the United States: 2014 through 2019
Authors: Kern David M. , Cepeda M. Soledad , Defalco Frank , Etropolski Mila 
Published: January 2020

Abstract
Background
Understanding how patients are treated in the real-world is vital to identifying potential gaps in care. We describe the current pharmacologic treatment patterns for the treatment of depression.

Methods
Patients with depression were identified from four large national claims databases during 1/1/2014–1/31/2019. Patients had ≥2 diagnoses for depression or an inpatient hospitalization with a diagnosis of depression. Patients were required to have enrollment in the database ≥1 year prior to and 3 years following their first depression diagnosis. Treatment patterns were captured at the class level and included selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, other antidepressants, anxiolytics, hypnotics/sedatives, and antipsychotics. Treatment patterns were captured during all available follow-up.

Results
We identified 269,668 patients diagnosed with depression. The proportion not receiving any pharmacological treatment during follow-up ranged from 29 to 52%. Of the treated, approximately half received ≥2 different classes of therapy, a quarter received ≥3 classes and more than 10% received 4 or more. SSRIs were the most common first-line treatment; however, many patients received an anxiolytic, hypnotic/sedative, or antipsychotic prior to any antidepressive treatment. Treatment with a combination of classes ranged from approximately 20% of first-line therapies to 40% of fourth-line.

Conclusions
Many patients diagnosed with depression go untreated and many others receive a non-antidepressant medication class as their first treatment. More than half of patients received more than one type of treatment class during the study follow up, suggesting that the first treatment received may not be optimal for most patients.
The mediating role of self-stigma and self-efficacy between intimate partner violence (IPV) victimization and depression among men who have sex with men in China
Authors: Peng Liping , She Rui , Gu Jing , Hao Chun , Hou Fengsu , Wei Dannuo , Li Jinghua 
Published: January 2020

Abstract
Background
Previous studies have shown that intimate partner violence (IPV) is prevalent in men who have sex with men (MSM). Mental health problems among MSM with IPV victimization have become a growing concern. The present study examined homosexual self-stigma and self-efficacy as potential mediators of the association between IPV victimization and depression.

Methods
We recruited 578 MSM from 15 cities across China. Participants completed sociodemographic measures, the IPV-GBM (IPV among gay and bisexual men) scale, the Self-Stigma Scale-Short Form (SSS-S), the General Self-Efficacy (GSE) Scale and the Center for Epidemiologic Studies Depression 10 (CES-D-10). We calculated bias-corrected 95% confidence interval (CI) for total, direct and indirect effects using bootstrapping to conduct mediation analyses.

Results
Findings showed that the prevalence of IPV victimization and depression were 32.7% (189/578) and 36.0% (208/578), respectively. Result from mediation analysis using structural equation modeling indicated that the association between level of IPV victimization and depression among MSM was fully mediated by higher homosexual self-stigma and lower self-efficacy. Homosexual self-stigma had a direct effect and an indirect effect via self-efficacy on depression.

Conclusion
The results provided evidence that integrated interventions that reduce self-stigma and foster self-efficacy could be promising approaches to decrease depression among MSM with IPV victimization.
Acute traumatic unilateral cervical C4–C5 facet dislocation in pediatric toddlers
Authors: Liawrungrueang Wongthawat , Chamnan Rattanaporn , Chaiyamongkol Weera , Bintachitt Piyawat 
Published: January 2020

AbstractBackgroundThe present study is to highlight the challenges in managing cervical spine injuries in toddlers (less than 4 years of age) without neurological deficit. Cases of unilateral cervical C4–C5 facet dislocation in toddlers are very rare.Case presentationA 3-year-old girl suffered cervical spine injury after a motor vehicle collision with unilateral C4–C5 facet dislocation without neurological deficit. Magnetic resonance imaging (MRI) showed no spinal cord injury, Frankel grade E. Initial management was cervical spine protection. Definite treatment and complication were discussed with the patient’s parents before closed reduction maneuver with minerva cast was applied under sedation. The patient showed no complication after closed reduction and the cervical spine had aligned well in radiographs. The minerva cast was removed at 8 weeks, at which point neck muscle stretching rehabilitation program started. At one-year follow up, the child was asymptomatic, had full active cervical motion and good function. In radiographs, the cervical spine had normal alignment and was healed.ConclusionsUnilateral cervical facet dislocation in toddlers is very rare. Closed reduction maneuver and the minerva cast applied were optional in this case. The parents were highly satisfied with the effective treatment and outcome.