bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-creation in learning and teaching: the case for a whole-class approach in higher education
Authors: Bovill Catherine 
Published: December 2019

AbstractThere is a wide range of activity in the higher education sector labelled ‘students as partners’ and ‘co-creation in learning and teaching’. Several frameworks have been proposed to map and categorise existing partnership and co-creation roles, activities, research, and practice. In this paper, I synthesise some of these frameworks to illustrate how the predominant focus in the international literature has been on partnership projects that select small groups of often already super-engaged or privileged students to participate. In contrast, co-creation in learning and teaching, embedded within the curriculum and involving a whole class of students, has been largely overlooked. I explore the potential of co-creating learning and teaching with a whole class of students (including face-to-face, blended, and online settings, and including lectures, tutorials, laboratories, and other methods of teaching); in other words, it is co-creation integral to students’ programmes and courses of study. I argue that whole-class approaches to co-creation may be inherently more inclusive of students than other approaches to co-creation and that this approach both relies upon, and contributes towards, building positive relationships between staff and students, and between students and students. I explore some of the challenges of whole-class co-creation in learning and teaching, and I also argue that the benefits suggest this is currently an underutilised and researched approach internationally.
Determining the mass-related reaction effectiveness factor of large, nonspherical fuel particles for bridging between intrinsic and apparent combustion kinetics
Authors: Szűcs Tibor , Szentannai Pal 
Published: December 2019

AbstractThe utilization of challenging solid fuels in the energy industry is urged by environmental requirements. The combustion kinetics of these fuel particles differs markedly from that of pulverized coal, mainly because of their larger sizes, irregular (nonspherical) shapes, and versatile internal pore structures. Although the intrinsic reaction kinetic measurements on very small amounts of finely ground samples of these particles are mostly available, a bridge toward their apparent reaction modeling is not evident. In this study, a method is introduced to build this bridge, the goodness of which was proved on the example of an industrially relevant biofuel. To do this, the results of a macroscopic combustion measurement with real samples in a well-modelable environment have to be used, and for considering some not negligible effects, 3D CFD modeling of the experimental environment is also to be applied. The outcome is the mass-related reaction effectiveness factor as a function of the rate of conversion. This variable can be considered as the active fraction of the entire particle mass on its periphery, and it can be used as the crucial element in modeling the combustion process of the same particle under other circumstances by including the actual boundary conditions. Another advantage of this method is its covering inherently the entire combustion process (water and volatile release, and char combustion) and also its applicability for reactors utilizing bigger particles like fluidized bed combustors.
Shaping space and practice to support autonomy: lessons from natural settings in Scotland
Authors: Barrable Alexia 
Published: December 2019

AbstractIn the present paper, I explore some of the concrete manifestation of autonomy support in natural childcare and early childhood education settings, under the organising framework of self-determination theory. More specifically, I present the ways in which early childhood educators shape the space of natural settings and use the affordances of the natural environment to promote autonomy in children aged 3–8 years. The practices presented are a result of direct observation in several Scotland-based outdoor settings, observations and organic conversations with educators in outdoor and forest kindergartens. Hopefully the practices and spaces presented in this paper can be of use by educators and setting managers who aim to support autonomous learning and intrinsic motivation in their pupils in outdoor natural early years’ settings.
F1000Prime recommended articles and their citations: an exploratory study of four journals
Authors: Wang Peiling , Williams Joshua , Zhang Nan , Wu Qiang 
Published: December 2019

AbstractThis study examined F1000Prime recommended research and review articles published in Cell, JAMA: The Journal of the American Medical Association, The Lancet, and The New England Journal of Medicine (NEJM) in 2010. The analyses included (1) the classifications assigned to the articles; (2) differences in Web of Science (WoS) citation counts over 9 years between the articles with F1000Prime recommendations and the other articles of the same journal; (3) correlations between the F1000Prime rating scores and WoS citation counts; (4) scaled graphic comparisons of the two measures; (5) content analysis of the top 5 WoS cited and top 5 F1000Prime scored NEJM articles. The results show that most of the recommended articles were classified as New Finding, Clinical Trial, Conformation, Interesting Hypothesis, and Technical Advance. The top classifications differred between the medical journals (JAMA, The Lancet, and NEJM) and the biology journal (Cell); for the latter, both New Finding and Interesting Hypothesis occurred more frequently than the three medical journals. The articles recommended by F1000 Faculty members were cited significantly more than other articles of the same journal for the three medical journals, but no significance was found between the two sets of articles in Cell. The correlations between the F1000Prime rating scores and WoS citation counts of the articles in the same journal were significant for the two medical journals (The Lancet and NEJM) and the biology journal (Cell). NEJM showed significances in both the upper quantile (top 50%), and the upper quartile (top 25%) sets. One of the medical journals, JAMA, did not show any significant correlation between the two measures. Despite the significant correlations of the three journals, Min–Max scaled graphic comparisons of the two measures did not reveal any patterns for predicting citation trends by F1000Prime rating scores. The peak citation year of the articles ranged from 2 to 8 years after the publication year for NEJM. Content analysis of the top-cited and top-scored NEJM articles found that highly commendable papers with comments such as “exceptional,” “landmark study,” or “paradigm shift” received varied rating scores. In comparison, some of the results corroborate with previous studies. Further studies are suggested to include additional journals and different years as well as alternative methods. Studies are needed to understand how F1000 Faculty assign ratings and what criteria they use. In addition, it is also worth investigating how F1000Prime users perceive the meanings of the ratings.
When Does Economic Freedom Promote Well Being? On the Moderating Role of Long-Term Orientation
Authors: Graafland Johan 
Published: December 2019

AbstractAn increasing volume of literature has shown that economic freedom is related to life satisfaction. However, life satisfaction may not fully describe well-being because of its subjective nature. This study contributes to previous literature by extending analysis of the relationship between economic freedom and life satisfaction to other dimensions of well-being as measured by the better life index of the OECD that includes both objective and subjective measures. A second innovation of this paper is that, in explaining the differences in well-being between countries, we conjecture that the relationship between free market institutions as measured by economic freedom and well-being is moderated by the cultural dimension of long-term orientation. This hypothesis is supported for six out of 11 dimensions of well-being: income, community, health, life satisfaction, safety, and work—life balance. Our study shows that looking at interdependencies between culture and formal institutions can increase the explanatory power of internationally comparative research into well-being.
In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [11C]ITDM in Mice
Authors: Bertoglio Daniele , Verhaeghe Jeroen , Korat Špela , Miranda Alan , wyffels Leonie , Stroobants Sigrid , Mrzljak Ladislav , Dominguez Celia , Liu Longbin , Skinbjerg Mette , Munoz-Sanjuan Ignacio , Staelens Steven 
Published: December 2019

AbstractPurposeThis study aimed at investigating binding specificity, suitability of reference region-based kinetic modelling, and pharmacokinetics of the metabotropic glutamate receptor 1 (mGluR1) radioligand [11C]ITDM in mice.ProceduresWe performedin vivoblocking as well as displacement of [11C]ITDM during positron emission tomography (PET) imaging using the specific mGluR1 antagonist YM-202074. Additionally, we assessedin vitroblocking of [3H]ITDM at two different doses of YM-202074. As an alternative to reference region models, we validated the use of a noninvasive image-derived input function (IDIF) compared to an arterial input function measured with an invasive arteriovenous (AV) shunt using a population-based curve for radiometabolite correction and characterized the pharmacokinetic modelling of [11C]ITDM in the mouse brain. Finally, we also assessed semi-quantitative approaches.ResultsIn vivoblocking with YM-202074 resulted in a decreased [11C]ITDM binding, ranging from − 35.8 ± 8.0 % in pons to − 65.8 ± 3.0 % in thalamus. Displacement was also markedly observed in all tested regions. In addition,in vitro[3H]ITDM binding could be blocked in a dose-dependent manner. The volume of distribution (VT) based on the noninvasive IDIF (VT (IDIF)) showed excellent agreement with theVTvalues based on the metabolite-corrected plasma input function regardless of the metabolite correction (r2 > 0.943,p < 0.0001). Two-tissue compartmental model (2TCM) was found to be the preferred model and showed optimal agreement with Logan plot (r2 > 0.960,p < 0.0001). A minimum scan duration of 80 min was required for proper parameter estimation. SUV was not reliable (r2 = 0.379,p = 0.0011), unlike the SUV ratio to the SUV of the input function, which showed to be a valid approach.ConclusionsNo suitable reference region could be identified for [11C]ITDM as strongly supported byin vivoandin vitroevidence of specific binding in all brain regions. However, by applying appropriate kinetic models, [11C]ITDM PET imaging represents a promising tool to visualize mGluR1 in the mouse brain.
Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study
Authors: Spada Marco , Porta Francesco , Righi Dorico , Gazzera Carlo , Tandoi Francesco , Ferrero Ivana , Fagioli Franca , Sanchez Maria Beatriz Herrera , Calvo Pier Luigi , Biamino Elisa , Bruno Stefania , Gunetti Monica , Contursi Cristina , Lauritano Carola , Conio Alessandra , Amoroso Antonio , Salizzoni Mauro , Silengo Lorenzo , Camussi Giovanni , Romagnoli Renato 
Published: December 2019

AbstractPrevious studies have shown that human liver stem-like cells (HLSCs) may undergo differentiation in vitro into urea producing hepatocytes and in vivo may sustain liver function in models of experimentally induced acute liver injury. The aim of this study was to assess the safety of HLSCs intrahepatic administration in inherited neonatal-onset hyperammonemia. The study was approved by the Agenzia Italiana del Farmaco on favorable opinion of the Italian Institute of Health as an open-label, prospective, uncontrolled, monocentric Phase I study (HLSC 01–11, EudraCT-No. 2012–002120-33). Three patients affected by argininosuccinic aciduria (patient 1) and methylmalonic acidemia (patients 2 and 3) and included in the liver transplantation list were enrolled. In all patients, HLSCs were administered by percutaneous intrahepatic injections (once a week for two consecutive weeks) within the first months of life. The first patient received 125,000 HLSCs x gram of liver/dose while the other two patients received twice this dose. No immunosuppression was administered since HLSCs possess immunomodulatory activities. None of the patients experienced infections, hyperammonemia decompensation, or other adverse events during the whole observation period. No donor specific antibodies (DSA) against HLSCs were detected. Patients were metabolic stable despite an increase (~30%) in protein intake. Two patients underwent liver transplantation after 19 and 11 months respectively, and after explantation, the native livers showed no histological alterations. In conclusion, percutaneous intrahepatic administration of HLSCs was safe in newborn with inherited neonatal-onset hyperammonemia. These data pave the way for Phase II studies in selected inherited and acquired liver disorders.
Self-Censorship and Associational Life in the Liberal Academy
Authors: Chamlee-Wright Emily 
Published: December 2019

AbstractSelf-censorship is a well-documented phenomenon within the academy. Building from the works of Tocqueville, Mill, and Smith, this paper identifies sources of self-censorship within the academy, namely the values of intellectual abrasion and civility, that are associated with the liberal intellectual tradition. The resulting phenomenon of self-censorship, I argue, has both positive and negative effects on the quality of public and academic discourse. Given the dual nature of self-censorship, scholars seeking to make the morally upright choice of whether to self-censor or to speak up face both an epistemological and a moral challenge. I argue that in discussions of the “impartial spectator” and the virtue of self-command, Adam Smith’s Theory of Moral Sentiments anticipates these challenges and lends guidance to the scholar who is sincerely committed to doing what is right when navigating associational life within the academy.
Fighter, Corpsman, Partisan an Attempt to Typify Former Soldiers Based on their Coping and Defense Mechanisms
Authors: Brants Loni , Schuy Katrin , Dors Simone , Horzetzky Marie , Rau Heinrich , Willmund Gerd , Ströhle Andreas , Siegel Stefan 
Published: December 2019

AbstractThis work strives to develop a typological classification of the use of conscious and unconscious defense and coping mechanisms based on methodically and structurally collected data from a qualitative survey of 43 former soldiers in Germany. Seven coping and defense types were identified:the Fighter, the Comrade, the Corpsman, the Strategist, the Partisan, the Self-Protectorandthe Infantryman. The types identified differed with regard to the accumulation, combination, and use of their conscious and unconscious defense and coping mechanisms in the superordinate areas ofbehaviour, relationships, emotions, reflexivityandtime focus. The typological classification could offer psychotherapeutic interventions tailored to individuals and their defense and coping mechanisms, which could lead to improved therapy use and compliance.
Oral Microcystin-LR Does Not Cause Hepatotoxicity in Pigs: Is the Risk of Microcystin-LR Overestimated?
Authors: Welten Richard D. , Meneely Julie P. , Chevallier Olivier P. , Kosek Vít , Greer Brett , Hajšlová Jana , Elliott Christopher T. 
Published: December 2019

AbstractThe global increase of toxin-producing cyanobacteria poses a serious risk to humans. Many investigations have shown that the cyanotoxin microcystin-LR induces hepatotoxicity in rodents. However, many of these studies applied the toxin intraperitoneally or used high oral concentrations, leading to an unrealistically high bioavailability of the toxin. Such approaches have put into question how these results translate to human exposure scenarios. Epidemiology studies have linked microcystin-LR with hepatotoxicity and liver cancer in humans, though by design these investigations cannot provide direct evidence. The present work investigated the effect of microcystin-LR exposure on pigs closely mimicking real-life human conditions. In two animal experiments, pigs were administered microcystin-LR daily by oral gavage for 35 days. Metabolomic and lipidomic tools were used to analyse blood and liver samples. In addition, blood biochemistry parameters indicative of liver function and health were studied to further investigate the potential hepatotoxic effects of microcystin-LR. Results indicated that the metabolomic and lipidomic analyses did not show a gross treatment effect in blood and liver. Furthermore, no significant alterations were found in the tested blood biochemistry parameters. No evidence of hepatotoxicity was found. These results shed more light onto the effects (or lack of effects) of low-dose oral microcystin-LR exposure. The data suggests that the risk of oral microcystin-LR exposure may be overestimated.
Raising Awareness of Researchers-in-the-Making Toward Responsible Research and Innovation
Authors: Lukovics Miklós , Udvari Beáta , Nádas Nikoletta , Fisher Erik 
Published: December 2019

AbstractAcross the globe, research, development, and innovation (RDI) processes are operating at increasingly accelerated paces, promising rapid development and higher standards of living, but also increasing the likelihood of unintended, socially undesirable effects that inevitably attend progress. The notion of responsible research and innovation (RRI) has emerged in response to this dilemma, and the integration of RRI into daily RDI practices itself represents a considerable challenge. Integrating RRI concepts and practices at an early or even pre-career stage, before researchers fully develop their daily routines, could strengthen the assimilation of RRI into RDI more generally. Thus, in line with the emphasis of RRI on science education, how to integrate RRI aspects in the thinking of researchers-in-the-making before they start their active research carrier is an important but under-investigated question. In addition, the special features of Generation Z currently being in higher education suggest the use nontraditional tools in science education.Accordingly, this exploratory study asks how the RRI-awareness of researchers-in-the-making can be raised. We adapt the Socio-Technical Integration Research (STIR) method, which facilitates reflection on societal aspects during scientific research practices and decisions, to the context of science education. We test the introduction of STIR among researchers-in-the-making studying natural sciences at the University of Szeged (Hungary). Our findings suggest potential steps for science education on RRI with attention to the special needs Generation Z and facilitating their RRI awareness for their active researcher career.
Flow pattern study in Beshar River and its two straight and meander reaches using CCHE2D model
Authors: Salmasi Farzin , Ayaseh Ahmad , Dalir Ali Hoseinzadeh , Arvanaghi Hadi 
Published: December 2019

AbstractIn this study, flow pattern in Beshar River as a main branch of Karoon River has been analyzed using CCHE2D. For this purpose, a 12-km reach upstream of Shahmokhtar hydrometric station near Yasuj city was considered. The CCHE2D model was calibrated using different Manning’s roughness coefficients and different turbulent models; for this purpose, numerical results were compared with observation data for three different discharges. The results showed that for the medium and high discharges, less Manning’s roughness coefficients (0.015 ≥ n ≥ 0.025) and for low discharge, higher Manning’s roughness coefficients (0.035 ≤ n ≤ 0.050) are more suitable. Also, k–ε turbulent model is more effective in this study. Besides, variations of hydraulic parameters like water depth, velocity, shear stress and Froude number are calculated and discussed. The analysis of the flow and velocity pattern in the straight and meander reaches of the river shows that the changes trend of the water surface gradient and velocity in the cross sections of this two reaches are different. Due to effect of secondary currents, latitude gradient of the water surface and depth average velocities increase to the outer bank of the bend. But in the straight reach, latitude gradient of the water surface is almost zero and the maximum velocities are in the center-line of flow. The R-squared (RSQ) and linear correlation coefficient (r) factors between velocity and shear stress show that there is linear and direct relationship between these two hydraulic parameters in the entire study reach.
Effects of tobacco–peanut relay intercropping on soil bacteria community structure
Authors: Gao Lin , Liu Xin-min , Du Yong-mei , Zong Hao , Shen Guo-ming 
Published: December 2019

Abstract
Purpose
A reasonable cultivation pattern is beneficial to maintain soil microbial activity and optimize the structure of the soil microbial community. To determine the effect of tobacco−peanut (Nicotiana tabacum−Arachis hypogaea) relay intercropping on the microbial community structure in soil, we compared the effects of relay intercropping and continuous cropping on the soil bacteria community structure.

Methods
We collected soil samples from three different cropping patterns and analyzed microbial community structure and diversity using high-throughput sequencing technology.

Result
The number of operational taxonomic units (OTU) for bacterial species in the soil was maximal under continuous peanut cropping. At the phylum level, the main bacteria identified in soil were Proteobacteria, Actinobacteria, and Acidobacteria, which accounted for approximately 70% of the total. The proportions of Actinobacteria and Firmicutes increased, whereas the proportion of Proteobacteria decreased in soil with tobacco–peanut relay intercropping. Moreover, the proportions of Firmicutes and Proteobacteria among the soil bacteria further shifted over time with tobacco–peanut relay intercropping. At the genus level, the proportions of Bacillus and Lactococcus increased in soil with tobacco–peanut relay intercropping.

Conclusion
The community structure of soil bacteria differed considerably with tobacco–peanut relay intercropping from that detected under peanut continuous cropping, and the proportions of beneficial bacteria (the phyla Actinobacteria and Firmicutes, and the genera Bacillus and Lactococcus) increased while the proportion of potentially pathogenic bacteria (the genera Variibacter and Burkholderia) decreased. These results provide a basis for adopting tobacco–peanut relay intercropping to improve soil ecology and microorganisms, while making better use of limited cultivable land.
Marriage Age, Social Status, and Intergenerational Effects in Uganda
Authors: Sunder Naveen 
Published: December 2019

AbstractThis study examines whether Ugandan women who marry at younger ages fare differently on a wide range of later-life outcomes than women who marry at later ages. Using a nationally representative data set, I identify the plausibly causal impacts of women’s marriage age by using age at menarche as an instrumental variable. Results indicate that a one-year delay in marriage for Ugandan women leads to higher educational attainment (0.5–0.75 years), literacy (10 percentage points), and labor force participation (8 percentage points). I also explore intergenerational effects of later marriage and find that the children of mothers who marry later have higher BMI (0.11 kg/m2) and hemoglobin levels (0.18 g/dl), and they are also less likely to be anemic (4 percentage points). Finally, I present evidence suggesting that the observed effects might be mediated through an enhancement of women’s agency within their household and positive assortative matching in the marriage market. By pointing to the beneficial consequences of delaying marriage, this research calls for concerted policy action to prevent child marriage.