bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Central Role for Canonical PRC1 in Shaping the 3D Nuclear Landscape
Authors: Boyle Shelagh , Flyamer Ilya M. , Williamson Iain , Sengupta Dipta , Bickmore Wendy A. , Illingworth Robert S. 
Published: December 2019

AbstractPolycomb group (PcG) proteins silence gene expression by chemically and physically modifying chromatin. A subset of PcG target loci are compacted and cluster in the nucleus to form observable bodies; a conformation which is thought to contribute to gene silencing. However, how these interactions influence gross nuclear organisation and their relationship with transcription remains poorly understood. Here we examine the role of Polycomb Repressive Complex 1 (PRC1) in shaping 3D genome organization in mouse embryonic stem cells (mESCs). Using a combination of imaging and Hi-C analyses we show that PRC1-mediated long-range interactions are independent of CTCF and can bridge sites at a megabase scale. Impairment of PRC1 enzymatic activity does not directly disrupt these interactions. We demonstrate that PcG targets coalesce in vivo, and that developmentally induced expression of one of the target loci disrupts this spatial arrangement. Finally, we show that transcriptional activation and the loss of PRC1-mediated interactions are seperable events. These findings provide important insights into the function of PRC1, whilst highlighting the complexity of this regulatory system.HighlightsLoss of RING1B substantially disrupts nuclear architecture.PRC1 mediated looping can occur at a Mb scale and is independent of CTCF.Polycomb mediated looping is driven by canonical PRC1 complexes.Multimeric PRC1-mediated interactions occur in vitro and in vivo.Disruption of PRC1-mediated looping is independent of gene activation.
Genetic characterization of African swine fever virus in Romania during 2018-2019 outbreak
Authors: Petrovan Vlad , Turcitu Mihai , Matei Lilia , Constantinescu Vlad , Zaulet Mihaela 
Published: December 2019

AbstractAfrican swine fever (ASF) is a highly contagious and lethal viral disease of swine with significant socio-economic impact in the developed and developing world. Since its reintroduction in 2007 in the Republic of Georgia, the disease has spread dramatically thorough Europe and Asia. Among the most affected countries in Europe is Romania, which initially reported the disease in 2017 and in 2018-2019 lost about 1 million pigs. There is no molecular characterization of the virus circulating in Romania during that reported period; therefore, the purpose of this study was to provide an initial molecular characterization using samples collected from two farms affected by ASFV. The causative strain belongs to genotype II, and its closest relatives are the strains circulating in Belgium, Russia, and China.
Simulation and Analysis of Animal Movement Paths using Numerus Model Builder
Authors: Getz Wayne M. , Vissat Ludovica Luisa , Salter Richard 
Published: December 2019

ABSTRACTAnimal movement paths are represented by point-location time series called relocation data. How well such paths can be simulated, when the rules governing movement depend on the internal state of individuals and environmental factors (both local and, when memory is involved, global) remains an open question. To answer this, we formulate and test models able to capture the essential statistics of multiphase versions of such paths (viz., movement-phase-specific step-length and turning-angle means, variances, auto-correlation, and cross correlation values), as well as broad scale movement patterns. The latter may include patchy coverage of the landscape, as well as the existence of home-range boundaries and gravitational centers-of-movement (e.g., centered around nests). Here we present a Numerus Model Builder implementation of two kinds of models: a high-frequency, multi-mode, biased, correlated random walk designed to simulate real movement data at a scale that permits simulation and identification of path segments that range from minutes to days; and a model that uses statistics extracted from relocation data—either empirical or simulated—to construct movement modes and phases at subhourly to daily scales. We evaluate how well our derived statistical movement model captures patterns produced by our more detailed simulation model as a way to evaluate how well derived statistical movement models may capture patterns occurring in empirical data.
Influences of dynamic capability on breakthrough innovation
Authors: Wang Haijun , Feng Junzhen 
Published: December 2019

Purpose
The purpose of this paper is to focus on the influences of dynamic capability on breakthrough innovation and explores the essential mechanisms related to such influence. The impact of breakthrough innovation on organizational performance is also examined in conjunction with the manufacturing industry samples in China.

Design/methodology/approach
This paper follows an empirical design. Data are collected from a survey administered to manufacturing samples in China. Regression analysis is used to test the hypothesis.

Findings
Results show that the positive impact of breakthrough innovation on organization performance is verified. Technological breakthrough innovation affects both the organization’s financial performance and growth performance in a linear and positive way, while market breakthrough innovation affects organization performance positively with marginal increments.

Research limitations/implications
This paper uses data of manufacturing industry of China, hence, an extended survey in depth and width is worthy of future investigation. In addition, more unique predisposing factors on breakthrough innovation should be considered in the context of China.

Practical implications
The research enriches the understanding of how the dynamic capability affects the enterprise’s breakthrough innovation, which helps entrepreneurs understand how to strategize to build dynamic capability during breakthrough innovation decisions and implementations.

Originality/value
Dynamic capability is uniquely viewed as a multi-dimensional concept from a perspective of modularity, while breakthrough innovation is composed of two constructs. It not only enriches the understanding of how dynamic capability affects breakthrough innovation but also discovers the non-linear impact of breakthrough innovation on enterprise’s organizational performance in the context of China’s manufacturing industry.
Structural risk of diversified project financing of city investment company in China based on the best worst method
Authors: Wang Yuning , Jin Xiaohua 
Published: December 2019

PurposeCity investment companies (CICs) in China, set up and funded by the government, are playing an important role in the construction of urban infrastructure in China. The purpose of this paper is to analyze the structural risk of diversified project financing of CICs and explore its key influencing factors.Design/methodology/approachThe best worst method (BWM) is used in this study to empirically analyze and quantitatively study the optimization of the structural risk of diversified financing of CICs.FindingsIn this study, the structural risk of diversified financing of CICs has been clearly defined, and its key evaluation indexes, including the structure of projects, the structure of financing, asset-liability ratio, earnings before interest and tax margin, the rate of return on capital and the ratio of long-term debt and short-term debt, have been determined. What is more, a comprehensive evaluation system of the structural risk of diversified financing has been established.Originality/valueThis study has established a comprehensive evaluation system of the structural risk of diversified financing. Based on the validated systematic evaluation, comparison and ranking of the structural risk of diversified financing of CICs by using the BWM, the ranking results can help investors to select the CICs with small structural risk of diversified financing to invest.
Political risk management of foreign direct investment in infrastructure projects
Authors: Jiang Weiling , Martek Igor , Hosseini M. Reza , Chen Chuan 
Published: December 2019

Purpose
Foreign direct investment in the infrastructure (FDII) of developing countries has a history of at least four decades. Bullish demand for foreign infrastructure services in developing countries, in combination with unstable political environments, has buoyed attention in political risk management (PRM). Even so, research into PRM of FDII remains fragmented and unmapped. Thus, the purpose of this paper is to identify the current body of knowledge in this area, uncover deficiencies and lay the foundation for further practical PRM research in FDII.

Design/methodology/approach
This paper offers a bibliometric-qualitative review of current literature on political risk in foreign infrastructure in developing countries. A 36-year period is identified, from 1983 to 2018. Publication year, area of focus, author(s), institution and country are classified and analyzed through the medium of social network analysis. The tools used are VOSviewer, CiteSpace and Gephi to analyze citation networks of 345 published papers. Out of 345 papers, 94 highly related studies were selected for further content analysis.

Findings
The study identified the research trends in related areas of PRM in infrastructure (e.g. PRM in international construction and foreign direct investment) by bibliometric analysis, which includes scattered researcher collaboration, wide-ranging and unfocused journal selection, unsystematic and discontinuous research themes. The specific research weakness in PRM in FDII is recognized by qualitative analysis from the perspective of PRM process, which reveals a lack of understanding of the impact of political risk factors, subjective risk estimations, lacking application of mature political risk database in FDII, combined with a shortage of complete and effective strategies for PRM in FDII in developing countries.

Originality/value
This paper is the first of its kind, providing a comprehensive benchmark survey of the research to date in PRM in foreign infrastructure investment in developing countries. It proposes a framework of future research agenda on PRM in FDII, including special issues on this topic, identification and assessment of political risk factors with objective methods, proposition of PRM strategies on FDII with proactive and active approaches, completing strategies of PRM with reactive strategies from the perspectives of whole life cycle of infrastructure projects, political risk factors and stakeholders. It also addressed the need to investigate the suitable literature databases for researching in this area.
From NPO to social enterprise: the story of Schwab awardee, Sharanjeet Shan
Authors: Krige Kerryn Ayanda Malindi , Hawarden Verity , Cohen Rose 
Published: December 2019

Learning outcomes
This case study introduces students to the core characteristics of social entrepreneurship by teaching Santos (2012) positive theory. The case allows students to transition from comprehension and application of what social entrepreneurship is, to considering how they operate. Druckers (2005) argument that social organisations will never have sufficient resources to do their work because they operate in an environment of infinite need is the catalyst for a conversation on resource dependency theory and the risks of mission drift. Students are introduced to the funding spectrum that can be used to understand the type of income that comes to an organisation, and to apply this to the case. By the end of their studies, students should be able to apply the Santos (2012) definition to social enterprises and social entrepreneurs, have insight into the complexity of operating in an environment of infinite need and able to apply the funding spectrum as a tool to manage to understanding financial sustainability.

Case overview/synopsis
The case tells the story of Sharanjeet Shan, a globally recognised social entrepreneur, and recipient of the Schwab Foundation’s Social Entrepreneur of the Year award in 2015. Shan moved to South Africa as the country moved into democracy, and has spent the past 20-plus years building the skills of Black African school children in mathematics and science through the organisation she leads, Maths Centre. But the country remains at the bottom of world rankings for the quality of its maths and science education, despite spending more per capita on education than any other country in Africa. Maths Centre has seen a dip in donations despite steady growth in the amount of money that businesses are investing in social change in South Africa through corporate social investment. But does Shan really need more donor income? Or are there other ways that she can build the financial sustainability of Maths Centre?

Complexity academic level
This case study is aimed at students of non-profit management, entrepreneurship, social entrepreneurship, women in leadership, corporate social investment, development studies and sustainable livelihoods. It is written at an Honours / Masters level and is therefore also appropriate for use in customised or short programmes. The case study is a good introduction for students with a background in business (e.g. Diploma in Business Administration / MBA / custom programmes) who are wanting to understand social enterprise and apply their learning's.

Supplementary materials
A list of supplementary materials is provided in the Teaching Note as Table I, which includes video's, radio interview recordings and a book chapter.

Subject code
CSS 3: Entrepreneurship.
Examining the determinants of green innovation adoption in SMEs: a PLS-SEM approach
Authors: Jun Wen , Ali Waheed , Bhutto Muhammad Yaseen , Hussain Hadi , Khan Nadeem Akhtar 
Published: December 2019

PurposeCurrently, environmental and social concerns have made green innovation more popular among researchers and practitioners around the globe. Developed countries tend to focus more on this issue, compared to developing countries. However, the reality shows that small- to medium-sized enterprises (SMEs) are considered as high contributors to environmental pollution. This study is designed for, and conducted on, SMEs in a developing country, Pakistan. The purpose of this paper is to highlight the main determinants of green innovation adoption in SMEs in Pakistan.Design/methodology/approachA data sample of 288 SMEs from five different sectors was collected and analyzed using the partial least squares structural equation modeling technique.FindingsThe results of the study indicate that organizational and human resource factors, market and customer factors, and government support and technological factors have a positive and significant impact, whereas external partnership and cooperation, and rules and regulatory factors have an insignificant impact on green innovation adoption in SMEs in Pakistan.Originality/valueThe outcomes of the study have important implications for managers as well as for government policy makers regarding framing better policies to promote green practices in SMEs.
Valuing prior learning
Authors: Fahrenbach Florian , Revoredo Kate , Santoro Flavia Maria 
Published: December 2019

PurposeThis paper aims to introduce an information and communication technology (ICT) artifact that uses text mining to support the innovative and standardized assessment of professional competences within the validation of prior learning (VPL). Assessment means comparing identified and documented professional competences against a standard or reference point. The designed artifact is evaluated by matching a set of curriculum vitae (CV) scraped from LinkedIn against a comprehensive model of professional competence.Design/methodology/approachA design science approach informed the development and evaluation of the ICT artifact presented in this paper.FindingsA proof of concept shows that the ICT artifact can support assessors within the validation of prior learning procedure. Rather the output of such an ICT artifact can be used to structure documentation in the validation process.Research limitations/implicationsEvaluating the artifact shows that ICT support to assess documented learning outcomes is a promising endeavor but remains a challenge. Further research should work on standardized ways to document professional competences, ICT artifacts capture the semantic content of documents, and refine ontologies of theoretical models of professional competences.Practical implicationsText mining methods to assess professional competences rely on large bodies of textual data, and thus a thoroughly built and large portfolio is necessary as input for this ICT artifact.Originality/valueFollowing the recent call of European policymakers to develop standardized and ICT-based approaches for the assessment of professional competences, an ICT artifact that supports the automatized assessment of professional competences within the validation of prior learning is designed and evaluated.
Heat transfer enhancement using second mode self-oscillating structures
Authors: Ali Samer , Shami Zein Alabidin , Badran Ali , Habchi Charbel 
Published: December 2019

Purpose
In this paper, self-sustained second mode oscillations of flexible vortex generator (FVG) are produced to enhance the heat transfer in two-dimensional laminar flow regime. The purpose of this study is to determine the critical Reynolds number at which FVG becomes more efficient than rigid vortex generators (RVGs).

Design/methodology/approach
Ten cases were studied with different Reynolds numbers varying from 200 to 2,000. The Nusselt number and friction coefficients of the FVG cases are compared to those of RVG and empty channel at the same Reynolds numbers.

Findings
For Reynolds numbers higher than 800, the FVG oscillates in the second mode causing a significant increase in the velocity gradients generating unsteady coherent flow structures. The highest performance was obtained at the maximum Reynolds number for which the global Nusselt number is improved by 35.3 and 41.4 per cent with respect to empty channel and rigid configuration, respectively. Moreover, the thermal enhancement factor corresponding to FVG is 72 per cent higher than that of RVG.

Practical implications
The results obtained here can help in the design of novel multifunctional heat exchangers/reactors by using flexible tabs and inserts instead of rigid ones.

Originality/value
The originality of this paper is the use of second mode oscillations of FVG to enhance heat transfer in laminar flow regime.
Research on performance of twin-core spun yarn and fabric
Authors: Su Xuzhong , Su Xuzhong , Liu Xinjin 
Published: December 2019

Purpose
As one kind of filament/staple fiber composite yarn, core spun yarn has been widely used, especially on Jeans. However, there is only one filament in the commonly used core spun yarn, such as spandex, and the performance of the one filament often is influenced during dyeing and finishing. Therefore, in the paper, twin-core spun yarns with two different filaments feeding simultaneously were spun on ring spinning frame modified by one kind of filament feeding numerical control device. The paper aims to discuss these issues.

Design/methodology/approach
Four kinds of twin-core spun yarns, cotton/spandex/PBT, cotton/spandex/CM800, cotton/spandex/T400, cotton/spandex/SPH with linear density 36.4tex/40D/50D were spun. For improving the covering effect of the two filaments, the filament feeding position, filament pre-drafting multiple, distance between two staple roving, designed twist factor of the core spun yarn were optimized.

Findings
It is shown that comparing with the core spun yarn, the breaking strength and elongation of the twin-core spun yarns are improved since the addition of another elastic filament, while the evenness is a little worse.

Originality/value
By using the twin-core spun yarns, corresponding knitted and woven fabrics are produced. Meanwhile, for simulating the dyeing and finishing process, the knitted fabrics were treated during the 150°C high temperature. It is shown that comparing with the fabrics produced by cotton/spandex yarn, addition of another elastic filament can improve the fabric strength and resistant and has positive effect on worsen prevention for high temperature treated fabric elastic recovery, and on change prevention during the dyeing and finishing process for fabric handle properties, and improves the fabric stability.
Bridging human rights and social determinants of health: Argentina, Chile, Paraguay, and Uruguay
Authors: Smart Juan , Letelier Alejandra 
Published: December 2019

Purpose
The purpose of this paper is to do a systematic assessment and testing of identified human rights norms alongside social determinant approaches in relation to identified health issues of concern in four Latin American countries (Argentina, Chile, Paraguay and Uruguay) to show how social determinants and human rights frameworks improve population health.

Design/methodology/approach
To do so, in the first part the authors analyze the inequalities both between and within each of the selected countries in terms of health status and health determinants of the population. Then, in the second section, the authors analyze the level of recognition, institutionalisation and accountability of the right to health in each country.

Findings
From the data used in this paper it is possible to conclude that the four analysed countries have improved their results in terms of health status, health care and health behaviours. This improvement coincides with the recognition, institutionalisation and creation of accountability mechanisms of human rights principles and standards in terms of health and that a human rights approach to health and its relation with other social determinants have extended universal health coverage and health systems in the four analysed countries.

Originality/value
Despite of the importance of the relation between human rights and social determinants of health, there are few human right scholars working on the issues of social determinants of health and human rights. Most of the literature of health and human rights has been focussed specific relations between specific rights and the right to health, but less human right scholar working on social determinants of health. On the other hand, just a few epidemiologists and people working on social medicine have actually started to use a universal human rights frame and discourse. In fact, according to Vnkatapuram, Bell and Marmot: “while health and human rights advocates have from the start taken a global perspective, social medicine and social epidemiology have been slower to catch up”.