bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic identification of chicken type I, II and III interferon-stimulated genes
Authors: Dai Manman , Xie Tingting , Liao Ming , Zhang Xiquan , Feng Min 
Published: May 2020

AbstractInterferon-stimulated genes (ISGs) play an important role in antiviral innate immune responses. Although many ISGs have been identified in mammals, researchers commonly recognize that many more ISGs are yet to be discovered. Current information is still very limited particularly for the systematic identification of type III ISGs. Similarly, current research on ISGs in birds is still in its infancy. The aim of this study was to systematically identify chicken type I (IFN-α), II (IFN-γ) and III (IFN-λ) ISGs and analyze their respective response elements. RNA sequencing (RNA-Seq) was employed to identify those genes with up-regulated expression following chicken IFN-α, IFN-γ and IFN-λ treatment. Two hundred and five type I ISGs, 299 type II ISGs, and 421 type III ISGs were identified in the chicken. We further searched for IFN-stimulated response elements (ISRE) and gamma-activated sequences (GAS) elements in the promoters region of ISGs. The GAS elements were common in the promoter of type II ISGs and were even detected in type I and III ISGs. However, ISRE were not commonly found in the promoters of chicken ISGs. Furthermore, we demonstrated that ISRE in chicken cells were significantly activated by IFN-α or IFN-λ treatment, and expectedly, that GAS elements were also significantly activated by IFN-γ treatment. Interestingly, we also found that GAS elements were significantly activated by IFN-λ. Our study provides a systematic library of ISGs in the chicken together with preliminary information about the transcriptional regulation of the identified ISGs.
Identification of a new effector-immunity pair of Aeromonas hydrophila type VI secretion system
Authors: Ma Shuiyan , Dong Yuhao , Wang Nannan , Liu Jin , Lu Chengping , Liu Yongjie 
Published: May 2020

AbstractThe type VI secretion system (T6SS) is a multiprotein weapon that kills eukaryotic predators or prokaryotic competitors by delivering toxic effectors. Despite the importance of T6SS in bacterial environmental adaptation, it is still challenging to systematically identify T6SS effectors because of their high diversity and lack of conserved domains. In this report, we discovered a putative effector gene, U876-17730, in the whole genome of Aeromonas hydrophila NJ-35 based on the reported conservative domain DUF4123 (domain of unknown function), with two cognate immunity proteins encoded downstream. Phylogenetic tree analysis of amino acids indicates that AH17730 belongs to the Tle1 (type VI lipase effector) family, and therefore was named Tle1AH. The deletion of tle1AH resulted in significantly decreased biofilm formation, antibacterial competition ability and virulence in zebrafish (Danio rerio) when compared to the wild-type strain. Only when the two immunity proteins coexist can bacteria protect themselves from the toxicity of Tle1AH. Further study shows that Tle1AH is a kind of phospholipase that possesses a conserved lipase motif, Gly-X-Ser-X-Gly (X is for any amino acid). Tle1AH is secreted by T6SS, and this secretion requires its interaction with an associated VgrG (valine-glycine repeat protein G). In conclusion, we identified a T6SS effector-immunity pair and verified its function, which lays the foundation for future research on the role of T6SS in the pathogenic mechanism of A. hydrophila.
Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway
Authors: Chang Yicong , Yuan Liang , Liu Jiarui , Muhammad Ishfaq , Cao Chuanbao , Shi Chenxi , Zhang Yuanyuan , Li Rui , Li Changwen , Liu Fangping 
Published: May 2020

AbstractLipopolysaccharide (LPS) as a major component of Escherichia coli cell wall can cause inflammation and cell death. Dihydromyricetin (ampelopsin, DHM) is a natural flavonoid compound with anti-inflammatory, anti-oxidant and anti-bacterial effects. The preventive effects of DHM against ileum injury remain unclear. Here, we explored the protective role of DHM against LPS-induced ileum injury in chickens. In this study, DHM significantly attenuated LPS-induced alteration in diamine oxidase, malondialdehyde, reduced glutathione, glutathione peroxidase and superoxide dismutase levels in chicken plasma and ileum. Histology evaluation showed that the structure of blood vessels in ileum was seriously fragmented and presence of necrotic tissue in the lumen in the LPS group. Scanning electron microscopic observation revealed that the surface of the villi was rough and uneven, the structure was chaotic, and the normal finger shape was lost in the LPS group. In contrast, 0.05% and 0.1% DHM treatment partially alleviated the abnormal morphology. Additionally, DHM maintained the barrier function by restoring the protein expression of occludin, claudin-1 and zonula occludens protein-1. DHM inhibited apoptosis through the reduction of the expression of bax and caspase-3 and restored the expression of bcl-2. Importantly, DHM could reduce ileum NLR family pyrin domain-containing 3 (NLRP3), caspase-1, interleukin (IL)-1β and IL-18 expression to protect tissues from pyroptosis and inhibited toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signalling pathway. In summary, DHM attenuated the ileum mucosal damage, oxidative stress and apoptosis, maintained barrier function, inhibited NLRP3 inflammasome and TLR4/NF-κB signalling pathway activation triggered by Escherichia coli LPS.
Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential
Authors: Cai Jiaxin , Wu Junyong , Wang Jiemin , Li Yongjiang , Hu Xiongbin , Luo Shifu , Xiang Daxiong 
Published: May 2020

AbstractMesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secreted by MSCs derived from different sources that contain therapeutic molecules such as RNA and proteins, which is a novel strategy for cell-free therapy. Recently, researches show EVs from MSCs (MSC-EVs) of different sources have special functions and effects on different diseases. Here, we collected these researches and compared them to each other. In addition, their potential and possible application in clinical treatment are described.
Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection
Authors: Zhang Qiaojuan , Martin-Caraballo Miguel , Hsia Shaochung V. 
Published: May 2020

AbstractHerpesvirus is ranked as one of the grand old members of all pathogens. Of all the viruses in the superfamily, Herpes simplex virus type 1 (HSV-1) is considered as a model virus for a variety of reasons. In a permissive non-neuronal cell culture, HSV-1 concludes the entire life cycle in approximately 18–20 h, encoding approximately 90 unique transcriptional units. In latency, the robust viral gene expression is suppressed in neurons by a group of noncoding RNA. Historically the lesions caused by the virus can date back to centuries ago. As a neurotropic pathogen, HSV-1 is associated with painful oral lesions, severe keratitis and lethal encephalitis. Transmission of pain signals is dependent on the generation and propagation of action potential in sensory neurons. T-type Ca2+channels serve as a preamplifier of action potential generation. Voltage-gated Na+channels are the main components for action potential production. This review summarizes not only the voltage-gated ion channels in neuropathic disorders but also provides the new insights into HSV-1 induced pain.
Perspective of placenta derived mesenchymal stem cells in acute liver failure
Authors: Saleh Mahshid , Taher Mohammad , Sohrabpour Amir Ali , Vaezi Amir Abbas , Nasiri Toosi Mohsen , Kavianpour Maria , Ghazvinian Zeinab , Abdolahi Shahrokh , Verdi Javad 
Published: May 2020

AbstractAcute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver disease. Since there are problems with liver transplantation including lack of donors, use of immunosuppressive drugs, and high costs of this process, new therapeutic approaches alongside current treatments are needed. The placenta is a tissue that is normally discarded after childbirth. On the other hand, human placenta is a rich source of mesenchymal stem cells (MSCs), which is easily available, without moral problems, and its derived cells are less affected by age and environmental factors. Therefore, placenta-derived mesenchymal stem cells (PD-MSCs) can be considered as an allogeneic source for liver disease. Considering the studies on MSCs and their effects on various diseases, it can be stated that MSCs are among the most important agents to be used for novel future therapies of liver diseases. In this paper, we will investigate the effects of mesenchymal stem cells through migration and immigration to the site of injury, cell-to-cell contact, immunomodulatory effects, and secretory factors in ALF.
Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA)
Authors: Malbrain Manu L. N. G. , Langer Thomas , Annane Djillali , Gattinoni Luciano , Elbers Paul , Hahn Robert G. , De laet Inneke , Minini Andrea , Wong Adrian , Ince Can , Muckart David , Mythen Monty , Caironi Pietro , Van Regenmortel Niels 
Published: May 2020

AbstractIntravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid administration as drug diluent or to preserve catheter patency, i.e., fluid creep, should also be considered. As for antibiotics, intravenous fluid administration should follow the four Ds: drug, dosing, duration, de-escalation. Among crystalloids, balanced solutions limit acid–base alterations and chloride load and should be preferred, as this likely prevents renal dysfunction. Among colloids, albumin, the only available natural colloid, may have beneficial effects. The last decade has seen growing interest in the potential harms related to fluid overloading. In the perioperative setting, appropriate fluid management that maintains adequate organ perfusion while limiting fluid administration should represent the standard of care. Protocols including a restrictive continuous fluid administration alongside bolus administration to achieve hemodynamic targets have been proposed. A similar approach should be considered also for critically ill patients, in whom increased endothelial permeability makes this strategy more relevant. Active de-escalation protocols may be necessary in a later phase. The R.O.S.E. conceptual model (Resuscitation, Optimization, Stabilization, Evacuation) summarizes accurately a dynamic approach to fluid therapy, maximizing benefits and minimizing harms. Even in specific categories of critically ill patients, i.e., with trauma or burns, fluid therapy should be carefully applied, considering the importance of their specific aims; maintaining peripheral oxygen delivery, while avoiding the consequences of fluid overload.
The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis
Authors: Gavelli Francesco , Shi Rui , Teboul Jean-Louis , Azzolina Danila , Monnet Xavier 
Published: May 2020

Abstract
Background
We performed a systematic review and meta-analysis of studies assessing the end-expiratory occlusion test (EEXPO test)-induced changes in cardiac output (CO) measured by any haemodynamic monitoring device, as indicators of preload responsiveness.

Methods
MEDLINE, EMBASE and Cochrane Database were screened for original articles. Bivariate random-effects meta-analysis determined the Area under the Summary Receiver Operating Characteristic (AUSROC) curve of EEXPO test-induced changes in CO to detect preload responsiveness, as well as pooled sensitivity and specificity and the best diagnostic threshold.

Results
Thirteen studies (530 patients) were included. Nine studies were performed in the intensive care unit and four in the operating room. The pooled sensitivity and the pooled specificity for the EEXPO test-induced changes in CO were 0.85 [0.77–0.91] and 0.88 [0.83–0.91], respectively. The AUSROC curve was 0.91 [0.86–0.94] with the best threshold of CO increase at 5.1 ± 0.2%. The accuracy of the test was not different when changes in CO were monitored through pulse contour analysis compared to other methods (AUSROC: 0.93 [0.91–0.95] vs. 0.87 [0.82–0.96], respectively, p = 0.62). Also, it was not different in studies in which the tidal volume was ≤ 7 mL/kg compared to the remaining ones (AUSROC: 0.96 [0.92–0.97] vs. 0.89 [0.82–0.95] respectively, p = 0.44). Subgroup analyses identified one possible source of heterogeneity.

Conclusions
EEXPO test-induced changes in CO reliably detect preload responsiveness. The diagnostic performance is not influenced by the method used to track the EEXPO test-induced changes in CO.
Trial registration The study protocol was prospectively registered on PROSPERO: CRD42019138265.
Low-cost data partitioning and encrypted backup scheme for defending against co-resident attacks
Authors: Tian Junfeng , Wang Zilong , Li Zhen 
Published: May 2020

AbstractAiming at preventing user data leakage and the damage that is caused by co-resident attacks in the cloud environment, a data partitioning and encryption backup (P&XE) scheme is proposed. After the data have been divided into blocks, the data are backed up using the XOR operation between the data. Then, the backup data are encrypted using a random string. Compared with the existing scheme, the proposed scheme resolves the conflict between data security and survivability via encrypted backup. At the same time, because the XOR-encrypted backup causes multiple data blocks to share the same backup data, the storage overhead of the user is reduced. In this paper, existing probabilistic models are used to compare the performances of an existing scheme and the P&XE scheme in terms of data security, data survivability and user storage overhead, and the overall performances of the two schemes in terms of these three aspects that are compared using control variables. Finally, the experimental results demonstrate the effectiveness of the P&XE scheme at improving user data security and survivability and reducing user storage overhead.
A signal reconstruction method of wireless sensor network based on compressed sensing
Authors: Zhu Shiyu , Chen Shanxiong , Peng Xihua , Xiong Hailing , Wu Sheng 
Published: May 2020

AbstractCompressed sensing (CS) is a new theory for sampling and recovering signal-based sparse transformation. This theory could help us to acquire complete signal at low cost. Therefore, it also satisfies the requirement of low-cost sampling since bandwidth and capability of sampling is not sufficient. However, wireless sensor network is an open scene, and signal is easily affected by noise in the open environment. Specially, CS theory indicates a method of sub-Nyquist sampling which is effective to reduce cost in the process of data acquirement. However, the sampling is “imperfect”, and the corresponding data is more sensitive to noise. Consequently, it is urgently requisited for robust and antinoise reconstruction algorithms which can ensure the accuracy of signal reconstruction. In the article, we present a proximal gradient algorithm (PRG) to reconstruct sub-Nyquist sampling signal in the noise environment. This algorithm iteratively uses a straightforward shrinkage step to find the optimum solution of constrained formula, and then restores the original signal. Finally, in the experiment, PRG shows excellent performance comparing to OMP, BP, and SP while signal is corrupted by noise.
Gel’fand-N-width in probabilistic setting
Authors: Tan Xin , Wang Yanan , Sun Lu , Shao Xingfeng , Chen Guanggui 
Published: May 2020

AbstractIn this article, we first put forward a new definition of probabilistic Gel’fand-$(N,\delta )$(N,δ)-width which is the classical Gel’fand-N-width in a probabilistic setting. Then we estimate the sharp order of the probabilistic Gel’fand-$(N,\delta )$(N,δ)-width of finite-dimensional space. Furthermore, we obtain the exact order of probabilistic Gel’fand-$(N, \delta )$(N,δ)-width of univariate Sobolev space by the discretization method according to the result of finite-dimensional space.
Strong consistency rates for the estimators in a heteroscedastic EV model with missing responses
Authors: Zhang Jing-Jing , Xiao Yun-Peng 
Published: May 2020

AbstractThis article is concerned with the semi-parametric error-in-variables (EV) model with missing responses: $y_{i}= \xi _{i}\beta +g(t_{i})+\epsilon _{i}$yi=ξiβ+g(ti)+ϵi, $x_{i}= \xi _{i}+\mu _{i}$xi=ξi+μi, where $\epsilon _{i}=\sigma _{i}e_{i}$ϵi=σiei is heteroscedastic, $f(u_{i})=\sigma ^{2}_{i}$f(ui)=σi2, $y_{i}$yi are the response variables missing at random, the design points $(\xi _{i},t_{i},u_{i})$(ξi,ti,ui) are known and non-random, β is an unknown parameter, $g(\cdot )$g(⋅) and $f(\cdot )$f(⋅) are functions defined on closed interval $[0,1]$[0,1], and the $\xi _{i}$ξi are the potential variables observed with measurement errors $\mu _{i}$μi, $e_{i}$ei are random errors. Under appropriate conditions, we study the strong consistent rates for the estimators of β, $g(\cdot )$g(⋅) and $f(\cdot )$f(⋅). Finite sample behavior of the estimators is investigated via simulations.
The entropy weak solution to a generalized Fornberg–Whitham equation
Authors: Li Nan , Lai Shaoyong 
Published: May 2020

AbstractWe investigate a nonlinear generalized Fornberg–Whitham equation. The key element is that we derive an $L^{2}(\mathbb{R})$L2(R) conservation law for solutions of the equation. We establish several estimates by utilizing the $L^{2}(\mathbb{R})$L2(R) conservation law. These estimates lead to the proof of the existence and uniqueness of entropy weak solution of the equation in the space $L^{1}(\mathbb{R})\cap L^{\infty}(\mathbb{R})$L1(R)∩L∞(R).
Further extension of Voigt function and its properties
Authors: Khan Nabiullah , Ghayasuddin Mohd , Khan Waseem A. , Abdeljawad Thabet , Nisar Kottakkaran Sooppy 
Published: May 2020

AbstractIn this paper, by using the confluent hypergeometric function of the first kind, we propose a further extension of the Voigt function and obtain its useful properties as (for example) explicit representation and partly bilateral and partly unilateral representation. By means of the present representations, we derive several (presumably new) generating functions which are partly bilateral and partly unilateral. Some interesting recurrence relations of the Voigt function introduced here are also indicated.
Stabilization of the weakly coupled plate equations with a locally distributed damping
Authors: Zhu Xianzheng 
Published: May 2020

AbstractIn this paper, we study the indirect stabilization of a system of plate equations which are weakly coupled and locally damped. By virtue of the general results due to Burq in the study of asymptotic behavior of solutions, we prove that the semigroup associated to the system is logarithmically stable under some assumptions on the damping and the coupling terms. For this purpose, we adopt an approach based on the growth of the resolvent on the imaginary axis, which can be obtained by some Carleman estimates.
Existence of nonoscillatory solutions tending to zero of third-order neutral dynamic equations on time scales
Authors: Qiu Yang-Cong , Jadlovská Irena , Chiu Kuo-Shou , Li Tongxing 
Published: May 2020

AbstractWe study the existence of nonoscillatory solutions tending to zero of a class of third-order nonlinear neutral dynamic equations on time scales by employing Krasnoselskii’s fixed point theorem. Two examples are given to illustrate the significance of the conclusions.
Reliable methods to study some nonlinear conformable systems in shallow water
Authors: Al-Shawba Altaf A. , Abdullah Farah A. , Azmi Amirah , Akbar M. Ali 
Published: May 2020

AbstractIn this paper, consider the eminent coupled Boussinesq–Burger (BB) equations and the coupled Whitham–Broer–Kaup (WBK) equations with time fractional derivative arising in the investigation of shallow water waves. The derivative is described in the sense of conformable derivative. We introduce the fundamental ${(G'} / {G} )$
(

G
′

/
G
)
-expansion method and its extension, namely the two-variable ${(G'} / {G}, {1} / {G} )$
(

G
′

/
G
,
1
/
G
)
-expansion method, to establish general solutions, some typical wave solutions existing in the literature, and some new and compatible soliton solutions comprised with certain parameters. For the definite values of these parameters, we derive and show in figures the well-known kink, singular kink, bell-shape soliton, periodic soliton, cuspon, and so on. The obtained solutions affirm that the introduced methods are reliable and efficient techniques to examine a wide variety of nonlinear fractional systems in the sense conformable derivative.
High-order compact scheme for the two-dimensional fractional Rayleigh–Stokes problem for a heated generalized second-grade fluid
Authors: Khan Muhammad Asim , Ali Norhashidah Hj. Mohd 
Published: May 2020

AbstractIn this article, an unconditionally stable compact high-order iterative finite difference scheme is developed on solving the two-dimensional fractional Rayleigh–Stokes equation. A relationship between the Riemann–Liouville (R–L) and Grunwald–Letnikov (G–L) fractional derivatives is used for the time-fractional derivative, and a fourth-order compact Crank–Nicolson approximation is applied for the space derivative to produce a high-order compact scheme. The stability and convergence for the proposed method will be proven; the proposed method will be shown to have the order of convergence $O(\tau + h^{4})$O(τ+h4). Finally, numerical examples are provided to show the high accuracy solutions of the proposed scheme.
Alpha fractional frequency Laplace transform through multiseries
Authors: Murugesan Meganathan , Abdeljawad Thabet , Gnanaprakasam Britto Antony Xavier , Jarad Fahd 
Published: May 2020

AbstractOur main goal in this work is to derive the frequency Laplace transforms of the products of two and three functions with tuning factors. We propose the Laplace transform for certain types of multiseries of circular functions as well. For use in numerical results, we derive a finite summation formula andm-series formulas. Moreover, we discuss various explanatory examples.
White noise theory and general improved Kudryashov method for stochastic nonlinear evolution equations with conformable derivatives
Authors: Hyder Abd-Allah 
Published: May 2020

AbstractThe aim of this work is to investigate the Wick-type stochastic nonlinear evolution equations with conformable derivatives. The general Kudryashov method is improved by a new auxiliary equation. So, a new technique, which we call “the general improved Kudryashov method (GIKM)”, is introduced to produce exact solutions for the nonlinear evolution equations with conformable derivatives. By means of GIKM, white noise theory, Hermite transform, and computerized symbolic computation, a novel technique is presented to solve the Wick-type stochastic nonlinear evolution equations with conformable derivatives. This technique is applied to construct exact traveling wave solutions for Wick-type stochastic combined KdV–mKdV equation with conformable derivatives. Moreover, numerical simulations with 3D profiles are shown for the obtained results.