bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and accuracy of pathological diagnosis in en‐bloc transurethral resection specimens versus conventional transurethral resection specimens of bladder tumour: evaluation with pT1 substaging by 10 pathologists
Authors: Yanagisawa Takafumi , Yorozu Takashi , Miki Jun , Iwatani Kosuke , Obayashi Koki , Sato Shun , Kimura Takahiro , Takahashi Hiroyuki , Egawa Shin 
Published: November 2020

AimsEn‐bloc transurethral resection (TUR) of bladder tumour (ERBT) is designed to provide more accurate pathological diagnosis of specimens than conventional TUR of bladder tumour (cTURBT). Some studies have reported that T1 bladder cancer substage could be a prognostic factor in assessing tumour progression, but such substaging has not been widely adopted because of problems with pathological diagnosis using cTURBT specimens. The aim of this study was to evaluate the possible advantages of en‐bloc TUR specimens in T1 substaging following assessment by a panel of 10 pathologists.Methods and resultsWe assessed the substages in 123 patients (cTURBT, n = 91; ERBT, n = 32) who were diagnosed with pT1 bladder cancer. We randomly selected 10 ERBT specimens and 10 cTURBT specimens with cancer invasion areas equivalent to those of their corresponding ERBT specimens. Ten pathologists performed pT1 substaging for pT1a/b/c and pT1m/e in 20 patients (cTURBT, n = 10; ERBT, n = 10). We evaluated diagnostic times and rates of diagnostic concordance among these pathologists, comparing cTURBT and ERBT. The median diagnostic times per slide were 87.7 s [interquartile range (IQR) 71.9–109.2 s) for cTURBT and 54.7 s (IQR 46.0–59.6 s) for ERBT (P = 0.009). The rate of diagnostic concordance was significantly better for ERBT specimens. For pT1a/b/c, the median concordance rates were 50% for cTURBT and 80% for ERBT (P = 0.02); for pT1m/e, the median concordance rates were 70% for cTURBT and 90% for ERBT (P = 0.05). For pT1a/b/c, the average κ‐values between the pathologist and the standard diagnosis were 0.04 for cTURBT and 0.47 for ERBT.ConclusionsThe use of ERBT specimens shortened the diagnostic time and minimised interobserver variability for T1 substaging compared with the use of cTURBT specimens.
Reconciliation and Mission
Authors: Engelsviken Tormod 
Published: November 2020

AbstractThis article discusses the message and ministry of reconciliation with a view to both its biblical content and its contemporary missional application. Within a salvation historical framework of missio Dei, the article outlines the biblical narrative about human beings created in the image of God for personal relationships with God, self, other people, and nature; the fall in sin and the human predicament that necessitate reconciliation; the historical reconciliation provided by God through the incarnation, atoning death, and victorious resurrection of Christ (the first stage); the message of reconciliation in the mission of the church; the present reception of reconciliation through faith in that message (the second stage); and the results of reconciliation both in relation to God (“vertical reconciliation”) and among human beings in the church and in the world (“horizontal reconciliation”), with an emphasis on peace, unity, love, forgiveness, righteousness, and freedom. Christ’s victory over and subjugation of all evil spirit powers are described as “cosmic reconciliation.” Because reconciliation may be partial in this world where sin still exists and evil powers are active, the eschatological hope is for a final reconciliation where the relationships to God, to other human beings, and to a recreated world are renewed and consummated.
Missional Resistance
Authors: Parker Stephen 
Published: November 2020

AbstractThe television series Man in the High Castle is set in an alternate United States of America reality where Nazi Germany and Japan won World War II. This paper explores the saga's themes narratively, scripturally, and missionally, engaging with various cultural, religious, and mission studies. The resistance theme of The Man in the High Castle in particular provides a useful parallel to Christian mission that is surprisingly resonant both with scripture and with Benjamin Simon's three pillars of mission. The oppressive values of the conquering empires lead to an awareness that there is a problem with the world, which encourages Christians toward mission and the series' Americans toward resistance. Finally, the success in The Man in the High Castle of sharing stories of “another world” as a scheme of resistance provides a useful strategy for Christians today. Mission, with a Man in the High Castle flavour, becomes an act of resistance to oppressive evil through the sharing of stories of the coming kingdom of God. Simon's three pillars of mission can all be seen in the approaches to mission seen from the series. Because the world is filled with oppressive values and needs Christian resistance, the pillar of transformation is required. The idea of sharing stories of an alternate world, the kingdom of God, is also an example of both gospel transmission and gospel translation into a fresh context.
Principles of Discipleship and Church Growth from Acts 2:46‐47
Authors: Josue Huaycani Cotrado Yiner 
Published: November 2020

AbstractThe purpose of this article is to make a comprehensive exegesis of the text of Acts 2:46‐47 and to extract basic biblical principles for the work of discipleship. Along with this topic, this article also analyzes the aspect of the growth of the church, since the study text indicates that the Lord added new converts to the church, although the church itself had an internal task to fulfil. Even though church growth has generally been distanced from doctrinal catechesis in the church in the same way that theology is divorced from ecclesiastical practice, this work attempts to show that a responsible and simple exegesis of the text can integrate the “theory” of doctrine with missionary practice and the responsibility to make disciples, so that the church increases in membership.
New Ecuadorian records of the eyeless banjo catfish Micromyzon akamai (Siluriformes: Aspredinidae) expand the species range and reveal intraspecific morphological variation
Authors: Chuctaya Junior , Encalada Andrea C. , Barragán Karla S. , Torres Maria L. , Rojas Karla E. , Ochoa‐Herrera Valeria , Carvalho Tiago P. 
Published: November 2020

AbstractTwo specimens of Micromyzon akamai, an eyeless and miniaturized species previously known only from the deep channels of the eastern Amazon basin in Brazil, are reported from the Curaray River, a tributary of the Napo River in Ecuador. The new specimens are the first records of Micromyzon in the headwaters of the Amazon River and the first records of M. akamai outside Brazil. External morphological characters and a phylogenetic analysis of cytochrome c oxidase I (coI) gene support the identification of the new specimens as M. akamai. Nevertheless, the new specimens also indicate that some features previously hypothesized to be apomorphic for M. akamai are intraspecifically variable.
Characterization and function study of a glutamyl endopeptidase homolog from Nocardia seriolae
Authors: Wang Wenji , Hou Suying , Chen Guoquan , Xia Liqun , Chen Jianlin , Wang Zhiwen , Lu Yishan 
Published: November 2020

AbstractGlutamic endopeptidases (Glu), belonging to the class of serine proteases, are a subfamily of chymotrypsin‐like proteolytic enzymes, which are regarded as important virulence factors in bacteria. However, the roles of glutamic endopeptidases of Nocardia seriolae in pathogenic process still remain uncertain. Here, a glutamic endopeptidase homolog from N. seriolae (GluNS) was cloned and its function was elucidated. GluNS encoded a 414‐aa protein which shared 93% identity to N. concava. In the phylogenetic tree, the glutamic endopeptidases of genus Nocardia clustered together firstly and then clustered with Streptomyces species. Moreover, GluNS was identified to be a secreted protein of N. seriolae and localized in the mitochondria of FHM cells. The transient overexpression of GluNS significantly induced increase in caspase‐3 activity and decrease in ΔΨm values in FHM cells. The number of apoptotic bodies was remarkably higher than that in control group. Taken together, GluNS overexpression induced apoptotic characteristics in FHM cells. This study provided new insights into the function of glutamic endopeptidase from N. seriolae.
High‐resolution Micro‐CT Myelography to Assess Spinal Subarachnoid Space Changes After Spinal Cord Injury in Rats
Authors: Zambrano‐Rodríguez Pablo C. , Bolaños‐Puchet Sirio , Reyes‐Alva Horacio J. , de Los Santos Roberto A. , Martinez‐Cruz Angelina , Guízar‐Sahagún Gabriel , Medina Luis A. 
Published: November 2020

ABSTRACTBACKGROUND AND PURPOSEThe spinal subarachnoid space (SSAS) is vital for neurologic function. Although SSAS alterations are known to occur after spinal cord injury (SCI), there is a lack of high‐resolution imaging studies of the SSAS after SCI in rodents. Therefore, the aim here was to assess changes in the SSAS of rats subjected to graded SCI, using high‐resolution micro‐CT myelography.METHODSLong‐Evans adult rats were subjected to mild or severe spinal cord contusion at T9. Imaging studies of SSAS features were carried out in injured rats at acute (day 1) and subacute (day 15) stages postinjury, as well as in control rats, using high‐resolution micro‐CT myelography with a contrast‐enhanced digital subtraction protocol. We studied a total of 33 rats randomly allocated into five experimental groups. Micro‐CT myelograms were assessed by expert observers using both qualitative and quantitative criteria.RESULTSQualitative and quantitative analyses showed that SCI induces changes in the SSAS that vary as a function of both injury severity and time elapsed after injury. SSAS blockage was the main alteration detected. Moreover, the method used here allowed fine details to be observed in small animals, such as variations in the preferential pathways for contrast medium flow, neuroimaging nerve root enhancement, and leakage of contrast medium due to tearing of the dural sac.CONCLUSIONMicro‐CT myelography provides high‐resolution images of changes in the SSAS after SCI in rats and is a useful tool for further experimental studies involving rat SCI in vivo.
Preschoolers’ true and false reports: Comparing effects of the Sequential Interview and NICHD protocol
Authors: Magnusson Mikaela , Joleby Malin , Ernberg Emelie , Akehurst Lucy , Korkman Julia , Landström Sara 
Published: November 2020

PurposeThe current study aimed to examine a Norwegian technique for conducting investigative interviews with preschoolers: the Sequential Interview (SI). The SI advocates for increased initial rapport building and includes a pre‐determined break before the substantive phase. To explore the potential benefits and risks of the SI, the technique was compared with an adapted version of the National Institute of Child Health and Development (NICHD) protocol.MethodsA total of 129 preschoolers (3–6 years) were interviewed with either the SI or NICHD protocol about a self‐experienced (Exp. I) or non‐experienced (Exp. II) event.ResultFor Exp. I, no significant difference was observed across interview conditions in the number of reported details about a self‐experienced event. Children interviewed with the SI exhibited a slightly lower accuracy rate compared to those interviewed with the NICHD protocol. For Exp. II, a total of 31.1% of the preschoolers initially assented to remembering a fictive (false) experience and 15.6% gave an account (>40 details) of the non‐experienced event. We found no difference between interviewing conditions in assent rates or number of false accounts.ConclusionsThe study provides valuable insights into the difficulties involved when interviewing young children. The results showed few differences between the novel SI model and the well‐established NICHD protocol. While many preschoolers could provide accurate testimony, some embedded worrisome false details in their narratives. Furthermore, a minority of children gave false reports about non‐experienced events when interviewed with the two techniques. Methodological limitations and suggestions for future research will be discussed.
Breastfeeding practices after a counselling intervention for factory workers in Bangladesh
Authors: Haider Rukhsana , Thorley Virginia , Yourkavitch Jennifer 
Published: November 2020

AbstractBreastfeeding may be particularly challenging for female factory workers who have long working hours and inadequate access to health information and care. In Chattogram, Bangladesh, a peer counselling intervention was undertaken to improve infant feeding practices of factory workers. Counselling started during pregnancy and continued until children were 18 months old. This article presents the results of a cross‐sectional survey undertaken during 2 weeks in March–April 2017, after the project's conclusion. The aim was to compare breastfeeding practices, specifically early breastfeeding initiation and exclusive breastfeeding (EBF), among factory workers who had received peer counselling in the intervention areas (IA) with those of non‐counselled factory workers in the nearby comparison areas (CA). Six female interviewers, trained over 3 days, conducted interviews at the workers' homes. Data were analysed to assess the association of peer counselling with infant feeding practices. Factory workers (N = 382) with infants between 0 and 18 months of age participated in the survey, in IA (n = 188) and in CA (n = 194). Although there were more health facility deliveries among the CA workers, only 43 (22%) of those workers had initiated breastfeeding within 1 h of birth versus 166 (88%) of the IA workers (p < .001). EBF prevalence on 24‐h recall in infants aged 0–6 months was only 7/83 (8%) for the CA workers versus 73/75 (97%) for IA workers (p < .001). The survey showed that breastfeeding practices of factory workers in the IA after the intervention were significantly better than those of factory workers in the CA.
Type and intensity of surrounding human land use, not local environment, shape genetic structure of a native grassland plant
Authors: Emel Sarah L. , Wang Shichen , Metz Richard P. , Spigler Rachel B. 
Published: November 2020

AbstractLandscape heterogeneity can shape genetic structure and functional connectivity of populations. When this heterogeneity imposes variable costs of moving across the landscape, populations can be structured according to a pattern of “isolation by resistance” (IBR). At the same time, divergent local environmental filters can limit gene flow, creating an alternative pattern of “isolation by environment” (IBE). Here, we evaluate IBR and IBE in the insect‐pollinated, biennial plant Sabatia angularis (L.) Pursh (Gentianaceae) across serpentine grasslands in the fragmented landscape of SE Pennsylvania, USA using ~4500 neutral SNP loci. Specifically, we test the extent to which radical alteration of the landscape matrix by humans has fundamentally altered the cost of movement, imprinting a pattern of IBR dictated by land use type and intensity, and the potential for IBE in relation to a gradient of heavy metal concentrations found in serpentine soil. We reveal a strong signal of IBR and a weak signal of IBE across sites, indicating the greater importance of the landscape matrix in shaping genetic structure of S. angularis populations in the study region. Based on Circuitscape and least cost path approaches, we find that both low‐ and high‐intensity urbanization resist gene flow by orders of magnitude greater than “natural” habitats, although resistance to low‐intensity urbanization weakens at larger spatial scales. While cropland presents a substantially lower barrier than urban development, cumulative human land use surrounding populations predicts within‐population genetic diversity and inbreeding in S. angularis. Our results emphasize the role of forest buffers and corridors in facilitating gene flow between serpentine grassland patches and averting local extinction of plant populations.
Severe onychomycosis management with oral terbinafine in a kidney transplantation setting: Clinical follow‐up by image analysis
Authors: Moreno‐Sabater Alicia , Ouali Nacéra , Chasset François , Frances Camille , Senet Patricia , Faucon Caroline , Hennequin Christophe , Bachmeyer Claude 
Published: November 2020

AbstractBackgroundSevere onychomycosis treatment in kidney transplant recipients (KTR) is challenging because of drug interactions and adverse events. Tacrolimus remains the antirejection treatment (ART) of choice in kidney transplantation but tolerance with systemic terbinafine for the management of severe onychomycosis has not been studied.ObjectiveThis study illustrates severe onychomycosis management in a kidney transplantation setting and investigates systemic terbinafine tolerance profile in KTR.Patients/MethodsWe retrospective analysed clinical data of KTR with a confirmed diagnosis of severe onychomycosis.ResultsWe retrieved a total of 29 KTR with severe onychomycosis needing an oral treatment to manage onychomycosis. In 55.1% (16/29) KTR, altered renal biological parameters or lack of guidelines to manage severe onychomycosis were the main reasons to deterring clinicians from prescribing oral treatments. 13 patients received an oral terbinafine treatment (9, 3 and 1 with a tacrolimus, cyclosporine and everolimus‐based ART, respectively). Clinical and biological follow‐up did not reveal severe drug interactions. ART blood levels showed significant variations in 2 patients without clinical consequences in renal graft. Two patients reported mild adverse events but after only one dose of terbinafine. Using an open‐source image analysis program, clinical evolution of onychomycosis could be retrospectively quantified and followed up.ConclusionsThe results presented here suggest that oral terbinafine can be proposed to treat severe onychomycosis with an acceptable tolerance profile in KTR with different ART such as tacrolimus and highlight the need of multicentric studies to establish guidelines for onychomycosis treatment in KTR.
Do Locals Need Our Help? On Participatory Research in Anthropology
Authors: Vargas‐Cetina Gabriela 
Published: November 2020

AbstractHere I argue that anthropologists, whether we want it or not, affect the localities and the people at our fieldwork sites. These effects can be short, medium or long‐term, depending on the place and the circumstances. Short term help may mean helping to pick up fruit or vegetables for dinner or lend a hand during the harvest. Mid‐term engagement may mean to set up a school for local teachers wanting to learn anthropological methods or participate over the years in a single project helping with help, funds, or both. Long‐term projects may include setting up museums and helping support them through foreign donations or working with locals through the mediation of a foreign or world‐wide institution such as the World Health Organization or the United Nations. There are specialty areas, such as medical anthropology, which could seem to have the in‐built purpose of achieving long‐term effects, but most other anthropological work does not fall within these categories and anthropologists can choose when and how to commit to local welfare depending on their circumstances and those of their hosts. Here I discuss the ways in which different anthropologists have chosen to engage with locals during and after fieldwork.
The SNL‐HDA19 histone deacetylase complex antagonizes HY5 activity to repress photomorphogenesis in Arabidopsis
Authors: Jing Yanjun , Guo Qiang , Lin Rongcheng 
Published: November 2020

Summary

Reprogramming of the transcriptome during photomorphogenesis requires dynamic changes in chromatin and distribution of histone modifications. However, the chromatin‐based regulation of this process remains to be elucidated.

Here, we identify the conserved SWI‐INDEPENDENT3 LIKE (SNL)‐HISTONE DEACETYLASE19 (HDA19) deacetylase complex, including HDA19 and SNL1–SNL6, as a negative regulator of the light signaling pathway. Light‐repression of HDA19 and SNLs expression is mediated by photoreceptors. HDA19 and SNLs are required for histone deacetylation and chromatin inactivation of PHYA gene. We further examined the interaction between SNL‐HDA19 complex and ELONGATED HYPOCOTYL5 (HY5), and their antagonistic regulation on the expressions of target genes.

The HDA19 deacetylase complex is recruited by HY5 to the chromatin regions of two positive light signaling genes, HY5 and B‐BOX CONTAINING PROTEIN 22 (BBX22), thereby reduces the accessibility and histone acetylation and represses their expression. HDA19, SNL1, and HY5 associate with the same regulatory regions of HY5 and BBX22, and HY5 binding to these loci is enhanced upon SNL‐HDA19 dysfunction.

Our study reveals a crucial role for the HDA19 deacetylase complex in light signaling and demonstrates that the functional interplay between chromatin regulators and transcription factors regulates photomorphogenetic responses to the changing light environments.
Bioenergy sorghum maintains photosynthetic capacity in elevated ozone concentrations
Authors: Li Shuai , Moller Christopher A. , Mitchell Noah G. , Lee DoKyoung , Ainsworth Elizabeth A. 
Published: November 2020

AbstractElevated tropospheric ozone concentration (O3) significantly reduces photosynthesis and productivity in several C4 crops including maize, switchgrass and sugarcane. However, it is unknown how O3 affects plant growth, development and productivity in sorghum (Sorghum bicolor L.), an emerging C4 bioenergy crop. Here, we investigated the effects of elevated O3 on photosynthesis, biomass and nutrient composition of a number of sorghum genotypes over two seasons in the field using free‐air concentration enrichment (FACE), and in growth chambers. We also tested if elevated O3 altered the relationship between stomatal conductance and environmental conditions using two common stomatal conductance models. Sorghum genotypes showed significant variability in plant functional traits, including photosynthetic capacity, leaf N content and specific leaf area, but responded similarly to O3. At the FACE experiment, elevated O3 did not alter net CO2 assimilation (A), stomatal conductance (gs), stomatal sensitivity to the environment, chlorophyll fluorescence and plant biomass, but led to reductions in the maximum carboxylation capacity of phosphoenolpyruvate and increased stomatal limitation to A in both years. These findings suggest that bioenergy sorghum is tolerant to O3 and could be used to enhance biomass productivity in O3 polluted regions.