bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease
Authors: Branchett William J. , O'Garra Anne , Lloyd Clare M. 
Published: June 2020

Background: Airway macrophages (AMs) are the most abundant leukocytes in the healthy airway lumen and have a highly specialised but plastic phenotype that is governed by signals in the local microenvironment. AMs are thought to maintain immunological homeostasis in the steady state, but have also been implicated in the pathogenesis of allergic airway disease (AAD). In this study, we aimed to better understand these potentially contrasting AM functions using transcriptomic analysis. Methods: Bulk RNA sequencing was performed on AMs (CD11c+ Siglec F+ CD64+ CD45+ SSChi) flow cytometry sorted from C57BL/6 mice during experimental AAD driven by repeated house dust mite inhalation (AMs HDM), compared to control AMs from non-allergic mice. Differentially expressed genes were further analysed by hierarchical clustering and biological pathway analysis. Results: AMs HDM showed increased expression of genes associated with antigen presentation, inflammatory cell recruitment and tissue repair, including several chemokine and matrix metalloproteinase genes. This was accompanied by increased expression of mitochondrial electron transport chain subunit genes and the retinoic acid biosynthetic enzyme gene Raldh2. Conversely, AMs HDM displayed decreased expression of a number of cell cycle genes, genes related to cytoskeletal functions and a subset of genes implicated in antimicrobial innate immunity, such as Tlr5, Il18 and Tnf. Differential gene expression in AMs HDM was consistent with upstream effects of the cytokines IL-4 and IFN-γ, both of which were present at increased concentrations in lung tissue after HDM treatment. Conclusions: These data highlight diverse gene expression changes in the total AM population in a clinically relevant mouse model of AAD, collectively suggestive of contributions to inflammation and tissue repair/remodelling, but with decreases in certain steady state cellular and immunological functions.
Risk Analysis of Sharia Bank Financing Contract
Authors: Riduwan Riduwan , Danupranata Gita 
Published: June 2020

Non-Performing Financing (NPF) is the inability of customers to meet their obligations in accordance with the contract, which can be categorized into three types namely substandard, doubtful and bad debt (macet). NPF is the main and biggest risk for sharia banks, hence the ability of sharia banks to identify, measure, monitor and control the risks of financing and capital provision is very important. Sharia banks will face greater risks than conventional banks because of the risk of sharia reputation. Besides being influenced by internal and external factors of sharia banks, NPF can also be influenced by the financing contract (akad) used.This study analyzes the level of financing risk based on the contract. The population and sample are all Sharia Rural Banks in Indonesia with 167 secondary data in the form of the publication of financial statements for 2011-2018. Analysis of the data using quantitative descriptive methods with a survey approach. The analyzed data are NPF data based on an eight year financing contract. This study managed to obtain data that the BPRS is more interested in financing with certainty of results, proven that murabahah has the highest outstanding compared to other contract. The results of this study also indicate that the low risk contract is in the murabahah contract, while the contract with the medium risk is in the mudarabah, musyarakah, multijasa, qard and istisna and the contract with the highest risk is salam and ijarah contract.
Detecting Bruise Damage and Level of Severity in Apples Using a Contactless NIR Spectrometer
Authors: Isingizwe Nturambirwe Jean Frederic , Nieuwoudt Helene H , Perold Willem Jacobus , Opara Umezuruike Linus 
Published: June 2020

HighlightsIn the Emission Head (EH) configuration differences in apple bruise severity were well captured.A good representation of new samples variability, in calibration, ensured robust quantitative PLS-DA models.EH mode with PLS-DA is an attractive spectroscopic option for inline apple sorting based on bruise damage. Abstract. Bruise damage in apples is very common and undesirable because it hinders consumer satisfaction and greatly contributes to food loss. Fast detection of bruise damage in fruit using spectroscopic systems is still problematic, especially in terms of quantitative and objective assessments of mechanical damage and standardization of bruise measurement method, among other issues. Non-destructive techniques among which is near infrared (NIR) spectroscopy are under development as a potential solution carrier for such issues. A study of bruise damage was conducted on three apple cultivars using Fourier transform (FT) near infrared spectroscopy in two configurations (‘emission head’ of Bruker’s Matrix-F and ‘integrating sphere’ of Bruker’s multipurpose analyzer, MPA). The emission head (EH) allows for contactless large sample (100 mm) exposure that simulates on-line applications, while the MPA (sample size: 22 mm) is commonly used for in-laboratory analysis of inhomogeneous material such as fruit. Bruise damages were mechanically induced in apples, bruise sizes measured physically and destructively. Partial least squares discriminant analysis (PLS-DA) was used to determine the differences captured by the scanning spectrometers in apple fruit tissues. Discriminant analysis revealed that in both sample acquisition modes, distinction between bruised and non-bruised apple fruit tissue was achieved with high (from 78% to 93%) accuracy of classification (ACcl) based solely on spectral data. The classification accuracy improved when individual cultivars were considered and ranged from 94% to 96%. Classification models were tested for robustness and showed that both cultivar and bruise severity had influence on classification models’ performance. The results showed ability of the emission head configuration in detecting bruises and differentiating between severity of bruises in apple fruit, thus making it a good candidate for use in rapid detection and quantitative assessment of bruising in apple on sorting lines. Possibilities for improving the classification model performance and ensuring their robustness for the EH were suggested. Keywords: Apple bruise, Discriminant analysis, Model performance, Model threshold, NIR spectroscopy.
Calibrating the APEX Model for Simulations of Environmental and Agronomic Outcomes on Dairy Farms in the Northeast U.S.: A Step-by-Step Example
Authors: Mason Rachel , Gorres Josef , Faulkner Joshua W. , Doro Luca , Merrill Scott C. 
Published: June 2020

HighlightsThis article details the method used to calibrate the APEX model for simulations of dairy farm silage corn production.Useful model outputs, plots, and metrics are discussed, as well as decision points and potential improvements.The article is intended as a helpful starting point for those who are new to APEX.Abstract. This article documents the procedure used to calibrate the Agricultural Policy/Environmental eXtender (APEX) model for a project that aimed to simulate crop yields, runoff, erosion, and nutrient losses on dairy farms under climate change. We describe each step in the calibration process, presenting the model outputs, plots, and metrics that were found to be useful, and discussing the decisions that needed to be made along the way. Calibration improved the performance of the model relative to an uncalibrated “baseline” version, and 0.22 &lt; NSE &lt; 0.49 and PBIAS within ±12% were achieved for most of the model outputs. While the mean annual silage yield was correct (PBIAS = 2%), the model did not accurately capture year-to-year yield variations (NSE = -1.6), and results for nitrogen in runoff were poor (NSE = -0.04, PBIAS = -69%).We therefore also outline several ways in which the method could be improved. Other calibration methods exist, and the procedure presented here will not be applicable in all situations. However, fully documented APEX calibrations are rare in the literature, and the number of non-expert model users may be growing. We therefore anticipate that this paper will serve as a useful point of entry for those who are new to APEX. We also hope that this work contributes to the development of transparent and reproducible procedures for modeling studies that have real-world implications. Keywords: APEX model, Hydrologic modeling, Methodology, Model calibration.
Evaluating Alternative Seed-Cotton Reclaimers for High-Speed Roller Ginning
Authors: Armijo Carlos B. , Whitelock Derek P. , Funk Paul A. , Thomas Joe W. 
Published: June 2020

HighlightsExperimental high-capacity seed-cotton reclaimers were evaluated for the growing high-speed roller-ginning industry.The experimental reclaimers minimized the amount of seed-cotton loss compared to the conventional reclaimer, but had more seed loss than a conventional reclaimer.The conventional reclaimer had the lowest combined seed and lint loss when processing Pima cotton.An experimental reclaimer based on a current cotton gin machine had seed and lint losses nearly $10 per cotton bale less than the conventional reclaimer when processing Upland cotton.Abstract. In a roller ginnery, a reclaimer machine removes partially-ginned or unginned seed cotton (carryover) from the mixture of carryover and ginned cottonseed that is expelled from the roller-gin stand during operation and returns the carryover to the gin stand for re-ginning. Conventional seed-cotton reclaimers are marginally adequate in their capacity to handle the increased carryover that high-speed roller ginning produces. Overloading a reclaimer often leads to choke-ups and downtime for the ginnery. The objective of this study was to develop and test high-capacity reclaimers. A modified 3-saw cylinder stick machine and a modified 2-saw cylinder gin-stand feeder were tested and compared to a conventional reclaimer. The saw-cylinders in the modified machines were operated at standard full speed, 1/2 of full speed, and 3/4 of full speed. Both Pima and Upland cotton were included in this study because there is a sizable amount of roller-ginned Upland cotton. Results showed that the experimental reclaimers reclaimed more carryover than the conventional reclaimer. An effective reclaimer will 1) reclaim carryover without also capturing residual seed that will likely be removed with cotton trash when returned to the gin stand feeder (seed loss) and 2) allow seed to pass through to the seed storage while minimizing the amount of residual carryover that escapes with the seed (carryover loss). The experimental reclaimers minimized the amount of residual carryover loss, but they had more residual seed loss than the conventional reclaimer. Increasing the saw-cylinder speeds of the experimental reclaimers decreased the residual seed loss but increased the residual carryover loss. Estimates of the value of the lost seed and of the lint on the lost carryover revealed that the conventional reclaimer had the lowest combined loss of $3.56 per bale when processing Pima cotton and the experimental 2-saw feeder with saw-cylinders operating at full speed had the lowest combined loss of $6.89 per bale when processing Upland cotton. The results suggest that losses of lint and seed may be further reduced by using a combination in series of different types of reclaimers to take advantage of each of their respective best features. Keywords: Cotton ginning, Roller ginning, Seed-cotton reclaimer.
Determinants of Good Work Ability among Organic and Conventional Farmers in Finland
Authors: Mattila Tiina E. A. , Rautiainen Risto H. , Hirvonen Maria , Väre Minna , Perkiö-Mäkelä Merja 
Published: June 2020

HighlightsDemand for organic food has increased in recent years, and public policies have favored organic products, but little attention has been paid to the organic farmers’ health and safety.We found that organic farmers have lower odds of having good work ability, indicating the need for safer working conditions, particularly for farmers considering switching to organic production.Abstract. Based on earlier studies, farmers have poorer work ability compared to workers in most other occupations. The aim of this study was to explore if organic production has a positive effect on producers’ work ability while controlling for demographic and production characteristics. This study used telephone interview data collected by the Finnish Institute of Occupational Health in 2014-2015. The material consisted of 2,164 farmers: 231 in organic production and 1,933 in conventional production. Work ability was measured with a single question regarding the farmers’ current work ability compared with their lifetime best on a scale of 0 to 10, with 0 meaning unable to work. The data were analyzed using multivariable logistic regression. Organic production had a negative effect on work ability, while larger farm size, experiencing economic uncertainty rarely/never/occasionally (vs. often), age under 55 years, having occupational health coverage, and experiencing low amounts of physical strain or mental strain had positive effects in a multivariable model. While this study could not consider potential biases from the farmers’ existing health status at the time of switching to organic production and other sources, it is clear that greater attention needs to be paid to improving worker health, safety, and wellness in organic farming. Keywords: Agricultural work, Agriculture, Farmer, Interview, Occupational health service, Occupational safety and health, Odds ratio, Risk factor, Sustainability.
Fano resonance based on D-shaped waveguide structure and its application for human hemoglobin detection
Authors: Liu Xing , Li Jina , Chen Jianfeng , Rohimah Siti , Tian He , Wang Jinfang 
Published: June 2020

Fano resonance is a pervasive resonance phenomenon which can be applied to high sensitivity sensing, perfect absorption, electromagnetic-induced transparency, and slow-light photonic devices. In this paper, we propose a metal–insulator–metal (MIM) waveguide structure consisting of a D-shaped cavity and a bus waveguide with a silver–air–silver barrier. The Fano resonance can be achieved by the interaction between the D-shaped cavity and the bus waveguide. The finite element method is used to analyze the transmission characteristics and magnetic-field distributions of the structure in detail. Simulation results show the Fano resonance can be adjusted by altering the geometric parameters of the MIM waveguide structure or the refractive index of the D-shaped cavity. The maximum refractive index sensitivity of the structure can reach up to 1510 nm/RIU, and there is a good linear relationship between resonance wavelength and refractive index. Since it has good sensitivity and tunability, the MIM waveguide structure can be used in bio-sensing, such as human hemoglobin detection. We show its applicability for the detection of three different human blood groups as well.
Experimental free-space quantum secure direct communication and its security analysis
Authors: Pan Dong , Lin Zaisheng , Wu Jiawei , Zhang Haoran , Sun Zhen , Ruan Dong , Yin Liuguo , Long Gui Lu 
Published: June 2020

We report an experimental implementation of free-space quantum secure direct communication based on single photons. The quantum communication scheme uses phase encoding, and the asymmetric Mach–Zehnder interferometer is optimized so as to automatically compensate phase drift of the photons during their transitions over the free-space medium. At a 16 MHz pulse repetition frequency, an information transmission rate of 500 bps over a 10 m free space with a mean quantum bit error rate of

0.49
%
±
0.27
%

is achieved. The security is analyzed under the scenario that Eve performs the collective attack for single-photon state and the photon number splitting attack for multi-photon state in the depolarizing channel. Our results show that quantum secure direct communication is feasible in free space.
High-gain amplification for femtosecond optical vortex with mode-control regenerative cavity
Authors: Zheng Shuiqin , Chen Zhenkuan , Lin Qinggang , Cai Yi , Lu Xiaowei , Gao Yanxia , Xu Shixiang , Fan Dianyuan 
Published: June 2020

Ultra-intense femtosecond vortex pulses can provide an opportunity to investigate the new phenomena with orbital angular momentum (OAM) involved in extreme cases. This paper reports a high gain optical vortex amplifier for intense femtosecond vortex pulses generation. Traditional regeneration amplifiers can offer high gain for Gaussian mode pulses but cannot amplify optical vortex pulses while maintaining the phase singularity because of mode competition. Here, we present a regeneration amplifier with a ring-shaped pump. By controlling the radius of the pump, the system can realize the motivation of the Laguerre–Gaussian [

LG

0
,
1
(
−
1
)

] mode and the suppression of the Gaussian mode. Without seeds, the amplifier has a donut-shaped output containing two opposite OAM states simultaneously, as our prediction by simulation. If seeded by a pulse of a topologic charge of 1 or

−
1

, the system will output an amplified

LG

0
,
1
(
−
1
)

mode pulse with the same topologic charge as the seed. To our knowledge, this amplifier can offer the highest gain as

1.45
×

10
6

for optical vortex amplification. Finally, we obtain a 1.8 mJ, 51 fs compressed optical vortex seeded from a 2 nJ optical vortex.
The harm that judges do – misunderstanding computer evidence: Mr Castleton’s story
Authors: Marshall Paul 
Published: June 2020

The reliability of computer systems, and the reliability of documents produced by computers, is important. There is a widely held perception that computers are fundamentally reliable. Further, it is commonly assumed that most computer errors are readily detectable or otherwise the result of user ‘input’ error. Since 1997 the courts have applied the presumption of the proper functioning of machines to computers. This article considered the case of Lee Castleton to illustrate that this presumption can have a devastating effect when applied.
Index words: software, electronic evidence, computer evidence, presumption of reliability
Diagnostic criteria for a “soft” pancreas and their influence on the occurrence of pancreatic fistula after pancreatoduodenal
Authors: Galchina Yu. S. , Kаrmаzаnovsky G. G. , Kalinin D. V. , Kondratyev E. V. , Gorin D. S. , Galkin G. V. , Kriger A. G. 
Published: June 2020

Purpose. Identification of the possibilities of contrast enhancement computed tomography in evaluated the number of the acinar structures in the pancreatic parenchyma at the preoperative stage to predict the development pancreatic fistula.Material and methods. In 2016–2019, 196 pancreatoduodenectomy were performed. 86 patients were retrospectively selected. Patients were divided into 2 groups: group 1 included 16 observations with the development of clinically significant pancreatic fistula, in 2 – 70 cases without complications. According to preoperative contrast enhancement computed tomography, structure of the pancreas, pancreatic parenchyma thickness, pancreatic duct diameter, the density of the pancreas in the native phase, relative parenchyma enhancement ratio, washout coefficient, pancreas stump volume were evaluated. According histological, the number of acinar and fat cells in the section of the removed pancreas was evaluated.Results. “Soft” structure of the pancreas (r = 0.374, p = 0.000), pancreatic parenchyma thickness (r = 0.549, p = 0.000), the density of the pancreas in the native phase of the scan (r = 0.568, p = 0.000), the values relative parenchyma enhancement ratio (r = 0.63, p = 0.000), pancreas stump volume (r = 0.508, p = 0.000) positively correlated with clinically significant pancreatic fistula and the number of acinar cells. Pancreatic duct diameter (r = −0.339, p = 0.001) negatively correlated with clinically significant pancreatic fistula and the number of acinar cells. Pancreatic fistula risk is 3.09 times higher with the number of acini more than 72.5%, sensitivity 75%, specificity 75.71%. Pancreatic fistula risk is 1.8 times higher with the density of the pancreas in the native phase over 35.5 HU sensitivity 62%, specificity 65%. Pancreatic fistula risk is 2.76 times higher with values parenchyma accumulation coefficient more than 1, sensitivity 75%, specificity 73%.Conclusions. Contrast enhancement computed tomography allows evaluating acinar index in the preoperative period to pick out the high-risk patient group to development of pancreatic fistula.
Complex treatment of hepatocellular carcinoma at early (BCLC-A) and intermediate (BCLC-B) stages
Authors: Kotiv B. N. , Dzidzava I. I. , Alent’yev S. A. , Smorodsky A. V. , Makhmudov K. I. , Apollonov A. A. , Soldatov S. A. , Zubarev P. N. 
Published: June 2020

Аim. Evaluation of the effectiveness of hepatocellular carcinoma treatment at early BCLC-A and intermediate BCLC-B stages by the combined use of liver resections and locoregional therapy.Materials and methods. The study included 142 patients with hepatocellular carcinoma. At the BCLC-A stage – 46 observations, at the BCLC-B stage – 96 observations. Chronic hepatitis and cirrhosis of various etiologies were detected in 58 (40.8%) patients. Liver resection of various volumes, transarterial chemoembolization and radiofrequency ablation were used for treatment. With the tumor progression and the ineffectiveness of locoregional therapy, targeted therapy was prescribed.Results. Four groups of patients were identified depending on treatment tactics. In group 1, 28 patients underwent radical liver resections; in group 2, 37 patients underwent preoperative transarterial chemoembolization and liver resection. In group 3, 63 patients underwent therapeutic transarterial chemoembolization and radiofrequency ablation. In group 4, 14 patients underwent transarterial chemoembolization followed by hepatic arterial infusion of chemotherapy and targeted therapy. Overall survival in groups 1 and 2 significantly exceeds survival rates in groups 3 and 4. The median overall survival in groups 1–4 was 39, 37.5, 19.5, and 7.5 months (p1–3 = 0.0001 ; p1–4 = 0.0009, p2–3 = 0.018 , p 2–4 = 0.001). The cumulative one, three and five year survival rates in groups 1 and 2 did not significantly differ (87.8% and 80.0%, 82.5% and 75.0%, 68.2% and 58.0%, 54.5% and 41.0%, respectively, p1–2 = 0.076). However, group 1 consisted exclusively of patients with BCLC-A stages with solitary tumors less than 6.5 cm in diameter, group 2 included large BCLC-A tumors and multiple tumors BCLC-B stages (67.6%).Conclusion. For the treatment of patients with hepatocellular carcinoma BCLC-A and BCLC-B stages, a multimodal approach should be applied, including differential use and a rational combination of regional chemotherapy and resection techniques, taking into account the functional state of the liver.
MENINGKATKAN KEMAMPUAN ANALITIK DAN AKTIVITAS SISWA SMP MELALUI PENERAPAN MODEL PEMBELAJARAN POE (PREDICTION, OBSERVATION, EXPLANATION)
Authors: Prasetiyaningsih Anis 
Published: June 2020

The research about the implementation of POE (Prediction, Observation, Explanation) learning model to improve the student’s analytical thinking ability and student’s activities in the learning process. This research used Classroom Action Research (CAR). It consist of two cycles. The object of research was 32 students of VIII F SMPN 3 Jember in Academic Year 2019/2020. The research instruments are observation sheets, test of student’s analytical thinking ability. The result of the study showed that the use of learning model POE improve from cycle I to cycle II include (1) the student’s analytical thinking 73% in cycle I to 88 % in cycle II (2) there was the improvement of student’s activities 74.5 % (Good) in cycle I to 82,4 % (Very Good) in cycle II