bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices
Authors: Dubrall Diana , Just Katja S. , Schmid Matthias , Stingl Julia C. , Sachs Bernhardt 
Published: March 2020

Abstract
Background
Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of spontaneous ADR reports regarding older adults (> 65) in the ADR database of the German Federal Institute for Drugs and Medical Devices (BfArM) and to set them in relation to i) the number of ADR reports concerning younger adults (19–65), and ii) the number of inhabitants and assumed drug-exposed inhabitants. The second aim was to analyse, if reported characteristics occurred more often in older vs. younger adults.

Methods
All spontaneous ADR reports involving older or younger adults within the period 01/01/2000–10/31/2017 were identified in the ADR database. Ratios concerning the number of ADR reports/number of inhabitants and ADR reports/drug-exposed inhabitants were calculated. The reports for older (n = 69,914) and younger adults (n = 111,463) were compared using descriptive and inferential statistics.

Results
The absolute number of ADR reports involving older adults increased from 1615 (2000) up to 5367 ADR reports (2016). The age groups 76–84 and 70–79 had the highest number of ADR reports with 25 ADR reports per 100,000 inhabitants and 27 ADR reports per 100,000 assumed drug-exposed inhabitants. For both ratios, the number of reports was higher for males (26 and 28 ADR reports) than for females (24 and 26 ADR reports). Fatal outcome was reported almost three times more often in older vs. younger adults. Six out of ten drug substances most frequently suspected were antithrombotics (vs. 1/10 in younger adults). For some drug substances (e.g. rivaroxaban) the ADRs reported most frequently differed between older (epistaxis) and younger adults (menorrhagia).

Conclusions
There is a need to further investigate ADRs in older adults since they occurred more frequently in older vs. younger adults and will likely increase in future. Physicians should be aware of different ADRs being attributed to the same drug substances which may be more prominent in older adults. Regular monitoring of older adults taking antithrombotics is recommended.
Pregabalin for postherpetic itch: a case report
Authors: Shimada Nobuhiro , Niwa Yasunori , Hotta Kunihisa , Igarashi Takashi , Takeuchi Mamoru 
Published: March 2020

Abstract
Background
Postherpetic itch has not commonly received attention as a complication of herpes zoster because pain predominates over itch in most patients with herpes zoster. Most cases of postherpetic itch are mild; however, cases of severe postherpetic itch reducing quality of life are rare.

Case presentation
A 52-year-old woman complained of severe itch in her left pinna and cheek 1 month after the first onset of herpes zoster at the same site. Owing to her scratching, she developed ulcers on her left pinna and cheek. Pregabalin was prescribed, and the itch subsided immediately, with the ulcers disappearing within 1 month.

Discussion
Severe itch was thought to be caused by neural injury from herpes zoster. Pregabalin may be a useful treatment option for neuropathic itch induced by herpes zoster.
Right inferior phrenic artery; Don't miss on MDCT before chemoembolization of hepatic dome HCC
Authors: Abdelgawad Mohamed Saied , Aly Rasha Abdelhafiz 
Published: March 2020

Abstract
Background
Transarterial chemoembolization (TACE) is considered a standard local-regional treatment for intermediate-stage hepatocellular carcinoma (HCC) and the most common bridging therapy. HCC typically receives its blood supply from the hepatic artery; however, it can recruit a parasitic supply from extrahepatic collateral arteries. The right inferior phrenic artery (RIPA) is considered the most common extrahepatic collateral pathway supplying HCC and so interfere with the therapeutic efficacy of TACE resulting in treatment failure and poor outcome. Imaging by MDCT with angiography has an essential role in depicting the presence or absence of an EHC arterial supply during the pre-TACE evaluation. We analyzed MDCT studies with CT angiography of patients with hepatic dome HCC retrospectively to confirm the diagnosis of HCC and to assess its blood supply. All patients were subjected to a proper assessment by history, clinical examination, as well as routine laboratory investigations

Results
Our study includes 58 cases with hepatic dome HCC. On CT angiography, the extrahepatic collateral from the RIPA supplying hepatic dome HCC was detected in about 33 out of 58 cases (56.9%). The RIPA arose directly from the aorta in 30 cases (90.9%) with only three cases (9.1%) from the celiac trunk. All cases were managed with TACE with about 25 out of 33 cases (75.8%) with extrahepatic RIPA were undergone concomitant embolisation of both RIPA and hepatic artery during TACE procedure.

Conclusion
MDCT assesses well the HCC arterial supply which is fundamental for planning subsequent cannulation and embolization of extrahepatic RIPA supply to hepatic dome HCC.
Sonographic and Doppler predictors of malignancy in ovarian lesions
Authors: Khalaf Lamiaa M. R. , Desoky Hagar H. M. , Seifeldein Gehan S. , Salah Asmaa , Amine Maged Abdelfattah , Hussien Marwa T. 
Published: March 2020

Abstract
Background
To determine the best sonographic (US) and/or Doppler features that the radiologist can use as predictors or risk factors for ovarian malignancy

Results
Among the examined 156 ovarian lesions, there were 53 malignant and 103 benign lesions. Most of the malignant ovarian lesions were noted in older age than in benign lesions p < 0.001. Majority of the malignant lesions had non-hyperechoic solid component (92.5%); it had the highest sensitivity of 92.5%, specificity of 97%, accuracy of 94.8%, positive predictive value of 94%, negative predictive value of 96%, and AUC of 0.94 in discrimination between benign and malignant ovarian lesions. The presence of papillary projection, the absence of wall definitions and thick wall, and thick septation were noted in 83%, 81%, and 53.8% of the malignant ovarian lesions respectively. Color flow Doppler shows neovascularity in 88.7% of the malignant lesions, 73.6% of them has central blood flow. The multivariate regression analysis revealed that the presence of non-hyperechoic solid component, new vascularity with central location of the blood flow, papillary projection, thick septa, and old age were the most significant parameters in predicting ovarian cancer in decreasing order of frequency according to their odds ratio (19.45, 7.55, 4.56, 3.45, and 1.45, respectively).

Conclusions
The non-hyperechoic solid component, new vascularity with central location of the blood flow, papillary projection, and thick septa were the most significant and consistent US and Doppler predictors of ovarian malignancy in addition to one clinical feature which is the old age ≥ 52 years.
A survey on the influence of intense rainfall induced by climate warming on operation safety and service life of urban asphalt pavement
Authors: Wang Wentao , Wang Linbing , Miao Yinghao , Cheng Chunru , Chen Shiwu 
Published: March 2020

AbstractIntense rainfall induced by climate warming is causing more common extreme meteorological events such as urban waterlogging in recent years. The urban waterlogging often has a wide-ranged severe impact on urban traffic. General intense rainfall weather makes urban transportation frequently be served in an environment with abundant water, which not only affects its operation safety but also challenges the service life of urban asphalt pavement. This paper presents a comprehensive survey on the influence of intense rainfall on urban transportation. The characteristics of meteorological phenomena such as climate warming, intense typhoon and rainfall, and urban waterlogging are firstly discussed. Then, Shenzhen, the city in south China, is chosen to analyze its historical meteorological variation in recent years, which was recently affected by a typhoon name Ewiniar in 2018 and caused severe waterlogging throughout entire city. Further, the operation safety of urban traffic is investigated with an increasing depth of surface runoff in intense rainfall weather, followed by the service life of asphalt pavement related to the moisture damage induced by dynamic pore water pressure. Finally, a series of measures to alleviate the effects of intense rainfall induced by climate warming on urban waterlogging and long service life of asphalt pavement are recommended.
Efficacy of a dementia intensive support (DIS) service at preventing admissions to medical and psychiatric wards: qualitative and quantitative evaluation
Authors: Rubinsztein Judy S. , Hatfield Catherine , High Liam , Krishnan Ramesh , Arnaoutoglou Nikitas A. , Goulia Panagiota , Dudas Robert , Ruhi Shamim , Wildschut Karel , Chouliaras Leonidas , Underwood Benjamin R. 
Published: March 2020

Aims and methodTo establish whether a dementia intensive support (DIS) service that is part of a crisis resolution and home treatment team for older people is preventing admissions to acute hospital and psychiatric wards. The number of referrals in 2017 to the DIS service was established and those admitted to hospital ascertained. Senior doctors examined 30 sets of notes in detail and reached a conclusion on whether DIS had contributed to admission prevention. This information was then re-examined in two meetings with at least eight senior psychiatrists present. A consensus opinion was then reached as to whether DIS had contributed to admission prevention in each case.ResultsOver 12 months, 30/171 patients (18%) referred were admitted to hospital. For the subset of 30 referrals examined in detail, DIS contributed to admission avoidance in 21 cases (70%).Clinical implicationsOur evaluation demonstrates that the DIS service is an effective way of preventing admission.
Shift in worker physiology and gene expression pattern from reproductive to diapause-like with colony age in the bumble bee Bombus impatiens
Authors: Treanore Erin D. , Kiner Jacklyn M. , Kerner Mackenzie E. , Amsalem Etya 
Published: March 2020

Insects maximize their fitness by exhibiting predictable and adaptive seasonal patterns in response to changing environmental conditions. These seasonal patterns are often expressed even when insects are kept in captivity, suggesting they are functionally and evolutionary important.
In this study we examined whether workers of the eusocial bumble bee Bombus impatiens maintained a seasonal signature when kept in captivity. We used an integrative approach and compared worker egg-laying, ovarian activation, body size and mass, lipid content in the fat body, cold tolerance and expression of genes related to cold tolerance, metabolism, and stress throughout colony development.
We found that bumble bee worker physiology and gene expression patterns shift from reproductive-like to diapause-like as the colony ages. Workers eclosing early in the colony cycle had increased egg-laying and ovarian activation, and reduced cold tolerance, body size, mass, and lipid content in the fat body, in line with a reproductive-like profile, while late-eclosing workers exhibited the opposite characteristics. Furthermore, expression patterns of genes associated with reproduction and diapause differed between early- and late-eclosing workers, partially following the physiological patterns.
We suggest that a seasonal signature, innate to individual workers, the queen or the colony is used by workers as a social cue determining the phenology of the colony and discuss possible implications for understanding reproductive division of labor in bumble bee colonies and the evolutionary divergence of female castes in the genus Bombus.
Toxicity of azo-dyes combined with TiO2 nanoparticles
Authors: Kroath M. , Punz E. , Joubert I.A. , Himly M. , Geppert M. 
Published: March 2020

Azo-dyes are organices compounds frequesntly used for food colring for example in sweets. A characteristic feature of az-=dyes is the axo-group (-N=N) as part of the chromophore. In parallel, nanoparticles (NPs) are more and more used as food additives and this, the encoubter of NPs with azo-dyes is highly likely. In particular, TiO2 NPs are inciroporated into foods under the tearm E171.
Nano-bio Interactions
Authors: Reichenfelser R. , Punz E. , Joubert I.A. , Geppert M. , Himly M. 
Published: March 2020

Due to theri extremely small size, nanoparticles display a unique set of characteristics, which differ significantly form bigger moieties. These characterstics also shape their interaction with biological entities. Theri large surface-to-volum area, for instance, makes paritcles in the nano- and micro-range very reactive. Clubmoss spores are an example of naturally occuring microparticles.
Opioid withdrawal and its stabilization on sublingual buprenorphine in intravenous drug users: A South Gujarat Perspective
Authors: Nemlekar Saumitra , Mehta Ritambhara , Dave Kamlesh , Chaudhari Falguni 
Published: March 2020

Aim of the studyOpioid Substitution Therapy involves replacing the client’s primary drug of use (opioid) with a medically safe drug or the same opioid in a safer mode of administration under medical supervision.Subject or material and methodsIt is a prospective follow up study observing opioid withdrawal and its stabilization on buprenorphine sublingual tablets. Patients who fulfilled the criteria for Opioid substitution therapy by NACO guidelines were enrolled and given buprenorphine sublingual tablets; (0.2mg and 2mg). They were followed up on 1st to 3rd, 7th, 14 and 28th day for assessment for withdrawal and its resolution on buprenorphine. The withdrawal was assessed using Clinical Opioid Withdrawal Scale (COWS). Duration of study was 2 years.ResultsTotal 44 patients were enrolled. 37 IDU users completed the period of observation. They belonged to 19 to 52 years age group, the duration of use ranged from 2 – 32 years. patients’ had mild to moderate range of withdrawal. The mean score of COWS was 11.2 with a range of 5 – 24. Mean Buprenorphine dose requirement on 1st day was 6.19mg with range from 1.2 to 14 mg. Dose requirement at day 28 was in the range from 0.6 – 16mg.DiscussionThere are many guidelines with fixed dose that are higher. We found lower dose requirements.ConclusionsThis study is empirical information on the issue of a reference dosage for buprenorphine regimen in an Indian Study population. However further research on such lines is required to suggest guidelines for Indian Population
Faktor Sikap dan Perilaku yang Berhubungan dengan Malaria di Wilayah Kerja Puskesmas Banjarmangu I Banjarnegara
Authors: Siti Zulaikhah Thomas , Sahariyani Menik , H Prasetyo Bhakti , M David Akbar , Rani Mustika 
Published: March 2020

Background: Malaria is an infectious disease caused by Plasmodium and transmitted to humans through the bite of infected female Anopheles. Characteristics of a person affecting the pattern of life that can contribute to the occurrence, attitudes and behaviors that is less attention to environmental related to Anopheles population can contribute to the malaria. In Indonesia, malaria is found in almost all regions. Some provinces are still malaria endemic areas, both low, medium and high. The number of malaria-based illnesses in API in Central Java in 2014 was recorded at 0.05 per 1000 population, and indigenous cases were still found in 5 districts, namely Purworejo, Banjarnegara, Purbalingga, Banyumas and Kebumen. Banjarnegara is one of the district in Central Java which is an endemic area of malaria, the patients as many 247, of that 102 patients in Puskesmas Banjarmangu I, Banjarmangu. This study aims to related factors attitude and behavior to the malaria. Method: The research was observasional analytic with case control design. The sample of 34 cases and 34 controls, with simple random sampling. Attitudes and behaviors were examined using logistic regression. Results: The result of study showed that attitude (p = 0,015; OR = 3,656; 95% CI = 1,292-10,344) and behavior (p = 0,031; OR = 2,962; 95% CI = 1,104-7,942) were significance relationship with malaria. Conclusion: Attitude and behavior related to the malaria in working area of Banjarmangu I, Banjarnegara. The dominant factors was attitude.
High-performance and ultraflexible PEDOT/silver nanowires/graphene films for electrochromic applications
Authors: Peng Hongchao , Jiang Hao , Tu Shijian , Zhang Sihang , Ren Erhui , Yan Bin , Yang Qin , Chen Sheng 
Published: March 2020

We fabricate a kind of flexible electrochromic (EC) film by spraying the mixed dispersion of silver nanowires (AgNWs) and poly (3, 4-ethylenedioxythiophene) (PEDOT) on the graphene (GR) electrode. AgNWs are embedded in the PEDOT nanoparticles, forming an interlaced conductive network and double electron transport channels; therefore, the disadvantages of poor conductive GR electrodes have been remedied effectively. The subsequent GR-based PEDOT/AgNWs composite films have revealed remarkable optical contrast (63%), high coloration efficiency (

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), and good cycle stability (keeping the optical contrast about 60% after switching cycles of 16,000 s). In addition, the GR-based composite films can keep good EC performance after 2000 cycles of bending tests, while those of the ITO/PET-based composite films decrease dramatically. The ultraflexible GR-based PEDOT/AgNWs composite films with excellent EC properties present an opportunity for fabricating large-area flexible EC devices.
High-field mid-infrared pulses derived from frequency domain optical parametric amplification
Authors: Leblanc A. , Dalla-Barba G. , Lassonde P. , Laramée A. , Schmidt B. E. , Cormier E. , Ibrahim H. , Légaré F. 
Published: March 2020

We present a novel, to the best of our knowledge, approach for scaling the peak power of mid-infrared laser pulses with few-cycle duration and carrier-to-envelope phase stabilization. Using frequency domain optical parametric amplification (FOPA), selective amplification is performed on two spectral slices of broadband pulses centered at 1.8 µm wavelength. In addition to amplification, the Fourier plane is used for specific pulse shaping to control both the relative polarization and the phase/delay between the two spectral slices of the input pulses. At the output of the FOPA, intrapulse difference frequency generation provides carrier–envelope phase stabilized two-cycle pulses centered at 9.5 µm wavelength with 25.5 µJ pulse energy. The control of the carrier–envelope phase is demonstrated through the dependence of high-harmonic generation in solids. This architecture is perfectly adapted to be scaled in the future to high average and high peak powers using picosecond ytterbium laser technologies.
High-speed single-pixel imaging by frequency-time-division multiplexing
Authors: Kanno Hiroshi , Mikami Hideharu , Goda Keisuke 
Published: March 2020

We propose and experimentally demonstrate high-speed single-pixel imaging by integrating frequency-division multiplexing and time-division multiplexing (techniques used widely in telecommunications) and applying the combined technique, namely, frequency-time-division multiplexing (FTDM), to optical imaging. Specifically, FTDM single-pixel imaging uses an array of broadband, spatially distributed, dual-frequency combs (i.e., spatial dual combs) for multidimensional illumination and detects an image-encoded time-domain signal with a single-pixel photodetector in a FTDM manner. As a proof-of-principle demonstration, we use the method to show ultrafast two-color (bright-field and fluorescence) single-pixel microscopy of breast cancer cells at a high frame rate of 32,000 fps and ultrafast image velocimetry of fluorescent particles flowing at a high speed of

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Genetic aspects of the pathogenesis of systemic lupus erythematosus in children
Authors: Kuchinskaya E. M. , Suspitsyn E. N. , Kostik M. M. 
Published: March 2020

The paper presents data on the pathogenesis of systemic lupus erythematosus (SLE), and depicts various molecular mechanisms for the development of SLE and lupus-like syndromes. It describes groups of diseases, such as apoptotic defects; NETosis; interferonopathies; complement deficiency; autotolerance disorders associated with mutations in the RAG1/RAG2 genes; hereditary metabolic diseases (prolidase deficiency, deficiency of adenosine deaminase 2; lysinuric protein intolerance; and α-mannosidase deficiency). The table summarizes clinical data on most of the known lupus-like syndromes and their molecular mechanisms.The pathogenesis of many forms of monogenic lupus-like diseases is being studied. The main sign suggesting in favor of the possible monogenic disease in a patient with SLE is its onset in infancy, especially in males. Attention should be also paid to a compromised family history, including to the marriage between close relatives, the resistance of disease to standard therapy, as well as atypical symptoms.
Lobular panniculitis in rheumatic diseases: the authors’ own data
Authors: Egorova O. N. , Belov B. S. , Radenska-Lopovok S. G. 
Published: March 2020

Objective: to study the clinical and laboratory features of lobular panniculitides (LPn) on a cohort of patients referred to the rheumatology center.Patients and methods. The investigation enrolled 687 patients (613 women and 74 men; mean age, 39.7±11.3 and 41.2±12.5 years, respectively) with panniculitis (Pn) who had received outpatient and/or inpatient treatment for diagnosed erythema nodosum or panniculitis at the V.A. Nasonova Research Institute of Rheumatology in 2007–2017.Results and discussion. By applying the diagnostic algorithm developed by the authors and the existing classification of Pn, the investigators diagnosed septal Pn in 430 (62.6%) patients and LPn in 249 (36.2%). The latter was associated with rheumatic diseases (RDs) in 97 (39%) patients. Most (70%) cases were patients with idiopathic LPn (ILPn), which, according to the 10th edition of the International Classification of Diseases, belongs to a group of systemic connective tissue disorders (M35.6), as well as those with systemic lupus erythematosus (SLE) (11.45%), dermatomyositis (DM) (9.37%), and rheumatoid arthritis (7%). This group showed a preponderance of females (the ratio of males to females was 1:7) with the chronic course of the disease mainly in ILPn. The clinical picture corresponded to four types of LPn, which may be of diagnostic and prognostic value in RDs.Conclusion. This investigation confirmed the relevance of studying LPn in RDs because of its negative impact on the course, severity and therapeutic efficiency of the underlying disease.