bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma
Authors: Huang Runzhi , Yan Gaili , Sun Hanlin , Zhang Jie , Song Dianwen , Kong Rui , Yan Penghui , Hu Peng , Xie Aiqing , Wang Siqiao , Zhuang Juanwei , Yin Huabin , Meng Tong , Huang Zongqiang 
Published: July 2020

Abstract
As the most common neoplasm in digestive system, hepatocellular carcinoma (HCC) is one of the most important leading cause of cancer deaths worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Alternative splicing events (ASEs) have a great effect in cancer development, progression and metastasis. We downloaded RNA sequencing and seven types of ASEs data of HCC samples, in order to explore the mechanism of ASEs underlying tumorigenesis and metastasis of HCC. The data were taken from the The Cancer Genome Atlas (TCGA) and TCGASpliceSeq databases. Univariate Cox regression analysis was used to determine a total of 3197 overall survival-related ASEs (OS-SEs). And based on five OS-SEs screened by Lasso regression, we constructed a prediction model with the Area Under Curve of 0.765. With a good reliability of the model, the risk score was also proved to be an independent predictor. Among identified 390 candidate SFs, Y-box protein 3 (YBX3) was significantly correlated with OS and metastasis. Among 177 ASEs, ATP-binding cassette subfamily A member 6 (ABCA6)-43162-AT and PLIN5-46808-AT were identified both associated with OS, bone metastasis and co-expressed with SFs. Then we identified primary bile acid biosynthesis as survival-related (KEGG) pathway by Gene Set Variation Analysis (GSVA) and univariate regression analysis, which was correlated with ABCA6-43162-AT and PLIN5-46808-AT. Finally, we proposed that ABCA6-43162-AT and PLIN5-46808-AT may contribute to HCC poor prognosis and metastasis under the regulation of aberrant YBX3 through the pathway of primary bile acid biosynthesis.
Phoneme and Stress Programming Interact During Nonword Repetition Learning
Authors: Meigh Kimberly M. , Cobun Emily , Yunusova Yana 
Published: July 2020

Purpose
Lexical stress and phoneme processes converge during phonological encoding, but the nature of the convergence has been debated. Stress patterns and phonemes may be integrated automatically and rigidly, resulting in a unified representation. Alternatively, stress and phoneme may be processed interactively based on sublexical contexts. The purpose of this study was to evaluate the extent to which the lexical stress and phoneme processing interact in a novel nonword learning paradigm.

Method
Twenty-seven adults with typical speech skills were trained to produce nonwords with specific phonemes, syllables, and stress patterns (Set 1) to an accuracy criterion. Then, participants repeated nonwords that varied from Set 1 in syllable position (Set 2), phoneme sequence (Set 3), included new phonemes (Set 4), or had new phonemes and stress patterns (Set 5). Nonword productions were perceptually analyzed, and phoneme and stress errors were counted.

Results
Participants' produced Set 1 nonwords with few phonemic or stress errors after training; a similar number of both types of errors were produced when comparing Sets 2 and 3. Greater phoneme and stress errors were produced on nonwords from Sets 4 and 5 compared to Sets 1–3. The highest number of phonemic errors occurred in Set 4 nonwords. There was no difference in the number of stress errors produced on nonwords in Sets 4 and 5.

Conclusion
The results of this study suggested that lexical stress and phoneme processing co-occurred and interacted during nonword productions. Trained stress patterns were learned during training; however, no evidence for a unified representation was observed. Negative interference was observed in nonwords with new phonemes and trained stress patterns, suggesting online phoneme processing may have dominated and interfered with the retrieval of stored metrical frames.
Inclusion of Signing Deaf or Hard-of-Hearing Students: Factors That Facilitate Versus Challenge Access and Participation
Authors: Salehomoum Maryam 
Published: July 2020

PurposePast studies have consistently indicated a need for improvements in inclusive educational practices. Many have focused on a single actor (e.g., the student), not taking into account the interactive nature of communication.MethodA qualitative study, involving multiple participants in two subject area general education high school classrooms, was completed to examine factors that promote versus challenge deaf or hard-of-hearing (DHH) students' access to communication and participation in classroom activities. Participants included four classroom teachers, two sign language interpreters, and three DHH students who used sign language as their primary mode of communication. Data consisted of eight 60- to 75-min in-class observations, two interviews, and three questionnaires. Data were analyzed using a participation framework of interaction as coordinated linguistic and nonlinguistic actions between multiple actors.ResultsDespite the availability of technological tools and sign language interpretation, DHH students had inconsistent access to classroom communication and lower participation than their hearing peers.ConclusionsThe results correspond to those of past studies, which suggest a research-to-practice gap that needs to be addressed if we are to see improvements in inclusive practices, particularly for students who use signed communication. Several recommendations are proposed in consideration of teacher, interpreter, and student as integral participants. Speech-language pathologists can participate in assessing whether inclusive education is meeting desired results and contribute to the development and implementation of necessary adaptations. Future studies are needed to systematically examine the efficacy of specific education and training programs.
TATOO: Tidal-chronology standalone tool to estimate the age of massive close-in planetary systems
Authors: Gallet F. 
Published: July 2020

Context. The presence of a massive close-in planet with an orbital period of a few days or less around a low-mass star can possibly result in a strong variation in the properties of the central star. Indeed, star-planet tidal interactions generate exchanges of angular momentum that can result in tidal spin-up. This effect could then lead to gyrochronological ages biased towards younger ages.
Aims. This article provides the community with TATOO, a standalone tool based on tidal-chronology, with which to estimate the age of a massive close-in planetary system using only its observed properties: mass of the planet and the star, stellar rotation, and planetary orbital periods.
Methods. I used a star-planet tidal evolution numerical code to create a large multi-parametric grid of the evolution of synthetic star-planet systems. Furthermore, using the tidal-chronology technique, I employed a 3D interpolation method to provide a fairly precise age estimate of any given planetary system composed of one massive close-in planet.
Results. About half of the planetary systems investigated in this work are subject to tidal spin-up bias. I pointed out that this bias linearly scales with the ratio between rotation and orbital period, making this quantity a useful proxy to rapidly investigate whether tidal-chronology needs to be used. Moreover, while being model dependent, TATOO can also be used even if no rotational departure is present. In that case, it gives results in agreement with the classical gyrochronological analysis.
Conclusions. TATOO is a useful tool specifically designed for massive close-in planetary systems that can also be used as a classical gyrochronological tool. For now it is the only publicly available software to estimate the age of massive close-in planetary systems subject to tidal spin-up. In that sense, tidal-chronology can be seen as a first order correction of the impact of tidal interaction on gyrochronology.
Directly imaged exoplanets in reflected starlight: the importance of knowing the planet radius
Authors: Carrión-González Ó. , García Muñoz A. , Cabrera J. , Csizmadia Sz. , Santos N. C. , Rauer H. 
Published: July 2020

Context. The direct imaging of exoplanets in reflected starlight will represent a major advance in the study of cold and temperate exoplanet atmospheres. Understanding how basic planet and atmospheric properties may affect the measured spectra is key to their interpretation.
Aims. We have investigated the information content in reflected-starlight spectra of exoplanets. We apply our analysis to Barnard’s Star b candidate super-Earth, for which we assume a radius 0.6 times that of Neptune, an atmosphere dominated by H2–He, and a CH4 volume mixing ratio of 5 × 10−3. The main conclusions of our study are however planet-independent.
Methods. We set up a model of the exoplanet described by seven parameters including its radius, atmospheric methane abundance, and basic properties of a cloud layer. We generated synthetic spectra at zero phase (full disc illumination) from 500 to 900 nm and a spectral resolution R ~ 125–225. We simulated a measured spectrum with a simplified, wavelength-independent noise model at a signal-to-noise ratio of 10. With a retrieval methodology based on Markov chain Monte Carlo sampling, we analysed which planet and atmosphere parameters can be inferred from the measured spectrum and the theoretical correlations amongst them. We considered limiting cases in which the planet radius is either known or completely unknown, and intermediate cases in which the planet radius is partly constrained.
Results. If the planet radius is known, we can generally discriminate between cloud-free and cloudy atmospheres, and constrain the methane abundance to within two orders of magnitude. If the planet radius is unknown, new correlations between model parameters occur and the accuracy of the retrievals decreases. Without a radius determination, it is challenging to discern whether the planet has clouds, and the estimates on methane abundance degrade. However, we find the planet radius is constrained to within a factor of two for all the cases explored. Having a priori information on the planet radius, even if approximate, helps improve the retrievals.
Conclusions. Reflected-starlight measurements will open a new avenue for characterizing long-period exoplanets, a population that remains poorly studied. For this task to be complete, direct-imaging observations should be accompanied by other techniques. We urge exoplanet detection efforts to extend the population of long-period planets with mass and radius determinations.
Prognostic features of NRAS missense mutations in adult acute myeloid leukemia patients
Authors: Sazonov S.V. , Vinogradov A.V. , Litvinova D.V. , Loboda A.N. , Rezaykin A.V. 
Published: July 2020

The aim of the study was to assess the prognostic significance of missense mutations in the NRAS gene in adult patients with acute myeloid leukemia (AML). Clinical observation was performed on 70 patients with AML. The average age of the examined was 52.0 ± 3.4 years. NRAS gene point mutations were detected using direct sequencing technique.According to the results of cytogenetic, immunohistochemical and PCR studies, a favorable prognosis was determined in 18 cases (25.7%), an intermediate in 15 (21.4%), and an unfavorable one in 18 cases (25.7%). In 19 samples (27.1%) genetic anomalies could not be detected; accordingly, the prognosis option for such patients was not specified.NRAS missense mutations were represented by T17A, C181A, A182C transversions (5 cases) and G35A, G38A transitions (3 cases), and a synonymous (silent) G360A substitution (1 case). Average frequency of prognostically significant NRAS mutations was 11.4%. All the above non-synonymous mutations were localized in exons 1-3, which caused the blocking of the internal GTPase activity of the N-ras protein and its stabilization in the active state. Clinically, all NRAS-positive AMLs were characterized by an unfavorable prognosis and primary tumor resistance to chemotherapy. The average follow-up of patients was 8.4 ± 8.2 months.
Traumaassoziierte Reanimation und vermeidbare Todesfälle bei Trauma
Authors: Buschmann Claas , Schmidt Uwe , Ondruschka Benjamin , Kleber Christian 
Published: July 2020

ZusammenfassungDas Trauma ist nach wie vor eine der führenden Todesursachen. Interdisziplinäre Analysen verstorbener Traumapatienten zeigten eine Rate vermeidbarer Todesfälle von ca. 15%. Definitiv vermeidbare Traumatodesfälle waren bedingt durch unbehandelte Spannungspneumothoraces, unerkannte Verletzungen, Blutungssituationen und Erstickungsvorgänge. Nicht nur in der Reanimationssituation nach Trauma müssen potenziell reversible Ursachen des Herz-Kreislauf-Stillstandes standardisiert adressiert werden.
Physical Match Performance in Sub-elite Soccer Players –
Introduction of a new Index
Authors: Reinhardt Lars , Schulze Stephan , Schwesig Rene , Kurz Eduard 
Published: July 2020

AbstractThis investigation examined the position-specific physical performance in
different locomotor categories and physiological demands concurrently in
official games of sub-elite players and to present a new performance index
(PI). Time-motion (distance, velocity, acceleration) and heart rate data of
55 soccer players were simultaneously captured via a GPS tracking system.
The relationship between external and internal match-load (PI) was
determined on the basis of heart rate, average velocity and acceleration. In
contrast to the mean heart rate (85.2±3.2%,
P=0.806, ηp²=0.03), the
average total distance covered (9946±715 m) was largely affected by
players’ position (P<0.001,
ηp²=0.63). Furthermore, a mixed design
ANOVA showed a large interaction effect between position and locomotor
category (P<0.001,
ηp²=0.44). On average, PI was
1.57±0.37 m/min²/%, with notably
lower values in the 2nd half. The position-specific profiles
already reported for higher leagues were also present in sub-elite soccer
players. Despite lower values for total distance and smaller distances in
the high-intensity zones (>14.4 km/h), internal
loads were comparable to those observed in European top leagues. In
comparison to a performance measure that ignores accelerations, PI was shown
to be less dependent on the playing position and had higher variability.
Consequently, PI is better suited to distinguish between players’
performance.
Effects of a 20-min Nap after Sleep Deprivation on Brain
Activity and Soccer Performance
Authors: Ajjimaporn Amornpan , Ramyarangsi Papatsorn , Siripornpanich Vorasith 
Published: July 2020

AbstractWe examined effects of a 20-min nap following 3 h of sleep
deprivation on brain wave activity, auditory reaction time, the
running-based anaerobic sprint test, leg muscle strength and the rating of
perceived exertion in male college soccer players. Eleven players underwent
three sleep conditions; normal sleep, sleep deprivation and 20-min nap after
sleep deprivation. The sleep deprivation demonstrated an increase in the
mean power of delta waves over the frontal area and a decrease in the mean
power of alpha waves over the parietal area compared to the normal sleep.
The nap and the sleep deprivation showed an increase in auditory reaction
time compared with those in the normal sleep. The sleep deprivation
demonstrated a decrease in the running-based anaerobic sprint test compared
to the normal sleep, whereas the nap has partially reversed only minimal
power and average power of the running-based anaerobic sprint test. The nap
showed a recovery effect on leg muscle strength, but not on the rating of
perceived exertion compared with the sleep deprivation. Thus, a 20-min nap
after sleep deprivation did not completely return brain activity back to
active state and did not entirely reverse the negative impact of sleep
deprivation on soccer performance in soccer players.
Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis
Authors: Zhang Shou-Fa , Li Li-Zhi , Zhang Wei , Guo Jin-Rong , Liu Fang-Fang , Ma Kai , Chen Shao-Hua , Zhang Ya-Qing 
Published: July 2020

AbstractIncreased plasma homocysteine (Hcy) levels have been widely documented in patients with overt hypothyroidism; however, the significance of Hcy level changes in patients with subclinical hypothyroidism (SCH) remains controversial. The aim of this meta-analysis was to determine the Hcy status in patients with SCH compared with euthyroid subjects. We searched PubMed, Embase, and Cochrane Library databases prior to December 2019 to identify eligible studies and assessed the quality of selected studies using the Newcastle-Ottawa Quality Assessment Scale. Publication bias was evaluated by Begg’s test and Egger’s test. Meta-regression analysis was conducted to investigate the source of heterogeneity. A likely source of heterogeneity was the year of the study. All statistical analyses were performed with RevMan 5.3 and Stata 12.0 software. Our meta-analysis of twelve observational studies with 684 patients showed that those with SCH aged between 18 and 65 years old were associated with a slightly increased plasma Hcy level compared with euthyroid controls. The pooled result of the weighted mean difference (WMD) of increased tHcy levels was 1.16 μmol/l (95% CI: 0.51, 1.82; p=0.0005). The Hcy level in patients with SCH aged between 18 and 65 years old is significantly increased compared to euthyroid controls.
Emerging Resistance of Gram Negative Pathogens in Community-Acquired Pneumonia
Authors: Amati Francesco , Restrepo Marcos I. 
Published: July 2020

AbstractIn recent decades, there has been a growing interest about the role of gram negative bacteria in community-acquired pneumonia (CAP), especially Pseudomonas aeruginosa, Enterobacteriaceae, and Acinetobacter baumannii. The prevalence of these pathogens differs largely according to the local ecology and the geographical location. Identifying gram negative bacteria, and in particular resistant gram negative bacteria, is of paramount importance in patients with CAP because these pathogens are associated with higher clinical severity and unfavorable outcomes. The use of individualized risk factors to predict each pathogen is a helpful strategy that needs to be locally validated. However, it should be taken into account that most of the risk factors identified in the literature are heterogeneously defined or lack consistency. New diagnostic techniques, such as molecular testing, are promising methods for early detection of these gram negative pathogens. The increasing mechanisms of resistance to antibiotics of these pathogens have limited our therapeutic approach. This narrative review focuses on the epidemiology, risk factors, diagnosis, and therapeutic options for the most relevant gram negative bacteria that cause CAP.
Q Fever (Coxiella Burnetii)
Authors: España Pedro Pablo , Uranga Ane , Cillóniz Catia , Torres Antoni 
Published: July 2020

AbstractQ fever is a zoonotic infectious disease caused by the Coxiella burnetii bacterium. It is an obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an acidified medium, forming a lysosome-like vacuole. It presents a peculiar phenomenon called “antigenic phase variation,” produced by a modification in the complexity of the membrane lipopolysaccharides. Q fever can be found worldwide and presents variable clinical features and geographical distribution. It mostly affects people in rural areas who are in contact with animals. The most common type of transmission to humans is via the inhalation of aerosols containing the pathogen, especially those formed from placental derivatives. Wild animals, domestic animals, and ticks are the principal reservoirs.Diagnosis is mainly made by indirect methods such as serology or by direct methods such as microbiological cultures or tests that detect the specific DNA. Typically, there are two clinical presentations: the acute disease, which is more frequent and often asymptomatic, and a persistent focalized infection in 4 to 5% of patients, generally with a poor evolution. Treatment of the acute form in both children and adults consists of administering doxycycline, while persistent focalized infection should be treated with at least two antibiotics, such as doxycycline and hydroxychloroquine. Several measures should be undertaken to minimize exposure among people working with animals or handling birth products. Different vaccines have been developed to prevent infection, though few data are available.
Open Galeazzi's Fracture-Dislocation in a 13-Year-Old Boy: A Case Report
Authors: Coppa Valentino , Senes Filippo M. 
Published: July 2020

Abstract
Background Galeazzi's fracture-dislocation (GFD) is a rare and complex injury consisting of a radial fracture associated with distal radioulnar joint (DRUJ) dislocation.
Case Description We are presenting a case of a boy, who at the onset showed an open GFD and his assessment after a 1-year follow-up. As a treatment, closed reduction and long-arm cast were performed. At the last follow-up, the patient presented a complete recovery of range of motion and function of the affected wrist.
Literature Review To the best of our knowledge, in the current literature, there are no reported cases of open GFD.
Clinical Relevance Although open GFD is rare this case report may suggest orthopaedic surgeon how to approach and manage it.
The Effect of Age on von Willebrand Factor and Bleeding Symptoms in von Willebrand Disease
Authors: Seaman Craig D. , Ragni Margaret V. 
Published: July 2020

Abstractvon Willebrand disease (VWD) is a quantitative or qualitative defect in von Willebrand factor (VWF) resulting in mucocutaneous bleeding symptoms and hemorrhage following hemostatic challenges, such as trauma or surgery. VWD-specific therapy, DDAVP (1-desamino-8-D-arginine vasopressin) and VWF concentrates, is necessary periprocedurally to ensure adequate hemostasis. The aging VWD patient may complicate this matter. The plasma concentration of many coagulation proteins, including VWF, increases with age. While it has been established that VWF levels increase with age in a healthy population, emerging research demonstrates this occurs in certain subtypes of VWD, too. Thus, the management of periprocedural VWD-specific therapy in the aging VWD patient is problematic when VWF levels increase over time to normal, and hematologists are left with uncertainty regarding whether or not periprocedural VWD-specific therapy is still necessary. In this article, we will review the current state of the literature regarding the effect of age on VWF levels in the healthy population and VWD while exploring possible etiologies for this phenomenon. Further, we will detail how this affects bleeding symptoms and highlight what research remains to be done to optimize care in this patient population.