bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life in Children with Migraine: A Case–Control Study
Authors: Sadeghian Saeid , Momen Aliakbar , Jelodar Gholamreza , Nasiri Shahram , Khalafinia Azin , Azizimalamiri Reza 
Published: July 2020

AbstractIn this article, we conducted a case–control study to determine the effects of migraine on quality of life (QOL) in children. Participants, aged between 6 and 18 years, were assigned to migraine (n = 70) and control (n = 70) groups. We used a translated version of Pediatric Quality of Life Inventory 4.0 questionnaire. From the children's perspective, the overall QOL scores in all domains were lower in children with migraine. Children in the migraine group had significant lower scores in the social, emotional, and physical functioning (p-value < 0.05) than control group. Interestingly, a significant difference in the educational performance was not seen (p-value = 0.101). Relative to the parents' responses and children, the overall scores in all domains were lower in children with migraine. Statistically significant lower scores were found only in emotional and physical domains (p-value < 0.05). The results of this study indicated that migraine imposes a substantial negative impact on the different aspects of QOL in children.
The Association between Needle Size and Waste Product and Its Effect on Cost-Effectiveness of Botulinum Toxin Injections?
Authors: Golan Shani , Pena John , Moore Jeffrey , Tandalam Sangeetha , Lelli Gary 
Published: July 2020

AbstractClostridium botulinum toxin (BT) must be administered intramuscularly with a syringe, but dead space in the syringe–needle complex may cause product waste and result in cost implications for the patient and provider. Syringe dead space is the volume of residual fluid that remains within the syringe after the plunger is fully depressed during medication injection. We calculated the average volume of remaining product in a syringe–needle complex and cost loss implication of this volume of BT. This is a single-center, analytical study using saline and four different sized needles for analytics of waste product and cost-effectiveness. Syringes of 1 mL with attached 18, 21, 30, and 32-gauge (G) needles, respectively, were compared. The syringe–needle complex was weighed before drawing 0.05 mL of saline. The fluid was then discarded with the appropriate syringe and then weighed again. This procedure was repeated for the four needle types and the average difference in weight of the syringe–needle complex before and after saline waste was measured. The volume was converted to units of BT used in clinical practice and the cost of waste product evaluated. The mean difference in needle–syringe complex weight before and after intervention was 0.068, 0.056, 0.04, and 0.026 g for the 18, 21, 30, and 32G needles, respectively. We found a statistically significant difference comparing the 18G with the 30 and 32G (0.02 and 0.0007, respectively) and comparing the 21G with the 30 and 32G (0.0042 and 0.00002, respectively). When we extrapolated the data to BT units (4U/0.1 mL), we found that theoretically 2.72, 2.24, 1.6, and 1.04 units of BT are left in the syringe–needle complex for the 18, 21, 30, and 32G syringes, respectively. At a cost of $6.01/U of onabotulinum toxin A, we then calculated a provider loss of a gross average (mean) revenue of $96 and 62.4 per 10 syringes used with 30 and 32G needles. Needle size used for drawing up and administering BT has an effect on the amount of waste product and subsequently on cost-effectiveness.
Biallelic Mutation of SETX and Additional Likely “In Cis” SETX Sequence Change in Ataxia with Oculomotor Apraxia Type 2
Authors: Perry Michael D. , Evans Martin J. , Byrd Philip J. , Taylor Malcolm R. 
Published: July 2020

AbstractAtaxia with oculomotor apraxia type 2 (AOA2) is a slowly progressive, autosomal recessive disease characterized by the triad of ataxia, oculomotor apraxia, and sensorimotor neuropathy. The genetic basis of AOA2 is biallelic mutation of the SETX gene, resulting in reduced or absent senataxin, a DNA/RNA repair protein essential for genomic stability.In this case report, we described a case of AOA2 with two clear pathogenic SETX mutations, one of which is novel. We then discussed two further likely “in cis” SETX sequence changes (previously reported in the literature as pathogenic), and presented the case that they are likely benign polymorphisms.
Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism
Authors: Kvaratskhelia Tamar , Abzianidze Elene , Asatiani Ketevan , Kvintradze Merab , Surmava Sandro , Kvaratskhelia Eka 
Published: July 2020

AbstractThe aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism analyses were used for genotyping of MTHFR polymorphisms. The results of this study suggest that the MTHFR C677T variant was significantly associated with hypothyroidism. In addition, in individuals with T allele risk of hypothyroidism significantly increased. Combination of CT/AA genotypes was more prevalent in the hypothyroid patients than in the control group. Thus, C677T polymorphism could be a possible genetic factor contributing to the pathophysiology of hypothyroidism, possibly through hyperhomocysteinemia.
Comparison of Simultaneous Capillary Blood Gases and End-Tidal Carbon Dioxide in Mechanically Ventilated Pediatric Patients with Acute Respiratory Failure
Authors: Konca Capan , Tekin Mehmet , Uckardes Fatih , Benli Samet , Kucuk Ahmet 
Published: July 2020

AbstractIn the follow-up of ventilation, invasive blood gas analysis and noninvasive monitoring of end-tidal carbon dioxide (ETCO2) are used. We aimed to investigate the relationship between capillary partial pressure of carbon dioxide (PcCO2) levels and ETCO2 and also to investigate ETCO2's predictive feature of PcCO2 levels. This study included 28 female and 30 male pediatric patients; 28 patients were type-1 respiratory failure (RF), 16 patients were acute respiratory distress syndrome, and 14 patients were type-2 RF. Our results showed a significant correlation between ETCO2 and PcCO2. Although the strength of the correlation was weak throughout the measurements, the strength of this correlation increased significantly in type-2 RF.
Exploring the Role of Pediatric Neurology in Determinations of Futility, Identifying Vulnerability, and Participating in Shared Decision Making through Case-Based Analysis
Authors: Quezada Julio , Lantos John D. 
Published: July 2020

AbstractIt is not uncommon for pediatric neurologists to encounter ethical dilemmas in clinical practice. These dilemmas not only require an exploration of the basic bioethical principles, but also considering that neurological disease can have impact on a person's self-identity. Patients with neurological disease are particularly vulnerable and at risk of having long-term sequelae of their nervous system and their individual selves. These important considerations can then raise the question of futility of treatment in a setting of uncertainty of outcome. In these complex situations, a pediatric neurologist plays an important role in shared decision making with both families and multidisciplinary teams. In this paper, we explore case-based scenarios that serve to demonstrate the unique character of ethics in neurology and the role of pediatric neurologists in finding solutions that are in a patient's best interest, have a minimal chance of harm, respect a patient's autonomy, and are just and promote justice.
Manipulation of cellular behaviour on surface-modified polyvinylidene difluoride using wet chemistry
Authors: Gabriel Matthias , Bollensdorff Christian , Raynaud Christophe Michel 
Published: July 2020

Abstract
The surface modification of polyvinylidene difluoride (PVDF) for various biomedical uses is notoriously hampered by the chemical inertness of the polymer. A wet chemical approach aiming at covalently grafting biomolecules was demonstrated by means of an elimination reaction of fluorine from the polymer backbone followed by subsequent modification steps. Exemplified as a possible biological application, the coupling of the peptide REDV rendered the material adhesive for endothelial cells while adhesion of thrombocytes was dramatically reduced.
How to transform graph states using single-qubit operations: computational complexity and algorithms
Authors: Dahlberg Axel , Helsen Jonas , Wehner Stephanie 
Published: July 2020

Abstract
Graph states are ubiquitous in quantum information with diverse applications ranging from quantum network protocols to measurement based quantum computing. Here we consider the question whether one graph (source) state can be transformed into another graph (target) state, using a specific set of quantum operations (LC + LPM + CC): single-qubit Clifford operations (LC), single-qubit Pauli measurements (LPM) and classical communication (CC) between sites holding the individual qubits. This question is of interest for effective routing or state preparation decisions in a quantum network or distributed quantum processor and also in the design of quantum repeater schemes and quantum error-correction codes. We first show that deciding whether a graph state |G⟩ can be transformed into another graph state |G′⟩ using LC + LPM + CC is

N
P

-complete, which was previously not known. We also show that the problem remains NP-complete even if |G′⟩ is restricted to be the GHZ-state. However, we also provide efficient algorithms for two situations of practical interest. Our results make use of the insight that deciding whether a graph state |G⟩ can be transformed to another graph state |G′⟩ is equivalent to a known decision problem in graph theory, namely the problem of deciding whether a graph G′ is a vertex-minor of a graph G. The computational complexity of the vertex-minor problem was prior to this paper an open question in graph theory. We prove that the vertex-minor problem is

N
P

-complete by relating it to a new decision problem on 4-regular graphs which we call the semi-ordered Eulerian tour problem.
Nitrogen-induced shift of photoluminescence from green to blue emission for xylose-derived carbon dots
Authors: Wang Shanshan , Yang Dong-Sheng , Yang Fuqian 
Published: July 2020

Abstract
The discovery of carbon dots opens a new avenue to the applications of nanomaterials in biosensing and bioimaging. In this work, we develop simple methods to prepare carbon nanoparticles from xylose and to tune the photoluminescence (PL) characteristics of the xylose-derived carbon nanoparticles via the combination of three different processes: hydrothermal carbonization (HTC), annealing at 850 °C and laser ablation (LA) in a NH4OH solution. The HTC-synthesized carbon dots (CDs) exhibit green emission under the 365 nm UV excitation, the annealing of the HTC-synthesized CDs leads to complete loss of the PL characteristics, and the LA processing of the annealed carbon nanoparticles recovers the PL characteristics with blue shift in comparison to the HTC-synthesized CDs under the same UV excitation. the PL characteristics of the HTC-CDs and the LA-CDs are dependent on the π-π* transition of C-containing surface-functional groups and π-π* and n-π* transitions of N-containing surface-functional groups, respectively, which are responsible for the difference in the PL characteristics between the HTC-synthesized CDs and the LA-processed CDs. The approaches demonstrated in this work provide a viable method to introduce and tune surface-functional groups on the surface of carbon nanoparticles.
Genome-wide discovery of pre-miRNAs: comparison of recent approaches based on machine learning
Authors: Bugnon Leandro A , Yones Cristian , Milone Diego H , Stegmayer Georgina 
Published: July 2020

Abstract

Motivation
The genome-wide discovery of microRNAs (miRNAs) involves identifying sequences having the highest chance of being a novel miRNA precursor (pre-miRNA), within all the possible sequences in a complete genome. The known pre-miRNAs are usually just a few in comparison to the millions of candidates that have to be analyzed. This is of particular interest in non-model species and recently sequenced genomes, where the challenge is to find potential pre-miRNAs only from the sequenced genome. The task is unfeasible without the help of computational methods, such as deep learning. However, it is still very difficult to find an accurate predictor, with a low false positive rate in this genome-wide context. Although there are many available tools, these have not been tested in realistic conditions, with sequences from whole genomes and the high class imbalance inherent to such data.

Results
In this work, we review six recent methods for tackling this problem with machine learning. We compare the models in five genome-wide datasets: Arabidopsis thaliana, Caenorhabditis elegans, Anopheles gambiae, Drosophila melanogaster, Homo sapiens. The models have been designed for the pre-miRNAs prediction task, where there is a class of interest that is significantly underrepresented (the known pre-miRNAs) with respect to a very large number of unlabeled samples. It was found that for the smaller genomes and smaller imbalances, all methods perform in a similar way. However, for larger datasets such as the H. sapiens genome, it was found that deep learning approaches using raw information from the sequences reached the best scores, achieving low numbers of false positives.

Availability
The source code to reproduce these results is in: http://sourceforge.net/projects/sourcesinc/files/gwmirna Additionally, the datasets are freely available in: https://sourceforge.net/projects/sourcesinc/files/mirdata
AEMDA: inferring miRNA–disease associations based on deep autoencoder
Authors: Ji Cunmei , Gao Zhen , Ma Xu , Wu Qingwen , Ni Jiancheng , Zheng Chunhou 
Published: July 2020

Abstract

Motivation
MicroRNAs (miRNAs) are a class of non-coding RNAs that play critical roles in various biological processes. Many studies have shown that miRNAs are closely related to the occurrence, development and diagnosis of human diseases. Traditional biological experiments are costly and time consuming. As a result, effective computational models have become increasingly popular for predicting associations between miRNAs and diseases, which could effectively boost human disease diagnosis and prevention.

Results
We propose a novel computational framework, called AEMDA, to identify associations between miRNAs and diseases. AEMDA applies a learning-based method to extract dense and high-dimensional representations of diseases and miRNAs from integrated disease semantic similarity, miRNA functional similarity and heterogeneous related interaction data. In addition, AEMDA adopts a deep autoencoder that does not need negative samples to retrieve the underlying associations between miRNAs and diseases. Furthermore, the reconstruction error is used as a measurement to predict disease-associated miRNAs. Our experimental results indicate that AEMDA can effectively predict disease-related miRNAs and outperforms state-of-the-art methods.

Availability and implementation
The source code and data are available at https://github.com/CunmeiJi/AEMDA.

Supplementary information
Supplementary data are available at Bioinformatics online.
Scalable machine learning-assisted model exploration and inference using Sciope
Authors: Singh Prashant , Wrede Fredrik , Hellander Andreas 
Published: July 2020

Abstract

Summary
Discrete stochastic models of gene regulatory networks are fundamental tools for in silico study of stochastic gene regulatory networks. Likelihood-free inference and model exploration are critical applications to study a system using such models. However, the massive computational cost of complex, high-dimensional and stochastic modelling currently limits systematic investigation to relatively simple systems. Recently, machine-learning-assisted methods have shown great promise to handle larger, more complex models. To support both ease-of-use of this new class of methods, as well as their further development, we have developed the scalable inference, optimization and parameter exploration (Sciope) toolbox. Sciope is designed to support new algorithms for machine-learning-assisted model exploration and likelihood-free inference. Moreover, it is built ground up to easily leverage distributed and heterogeneous computational resources for convenient parallelism across platforms from workstations to clouds.

Availability and implementation
The Sciope Python3 toolbox is freely available on https://github.com/Sciope/Sciope, and has been tested on Linux, Windows and macOS platforms.

Supplementary information
Supplementary information is available at Bioinformatics online.
Percutaneous closure of iatrogenic anterior mitral leaflet perforation: a case report
Authors: Naeim Hesham Abdo , Amoudi Osama , Mahmood Abeer , Abuelatta Reda 
Published: July 2020

Abstract

Background
Severe mitral regurgitation (MR) through the body of the anterior mitral leaflet (AML) is rare. The cause either iatrogenic during open-heart surgery or due to infective endocarditis. We present a case where a successful percutaneous closure of the AML perforation was an alternative to surgery.

Case summary
A 60-year-old male presented with shortness of breath (SOB) class III of 12 months duration. He underwent coronary artery bypass surgery with four grafts plus mitral valve (MV) repair 20 months ago. Transthoracic echocardiogram (TTE) and transoesophageal echocardiogram (TOE) revealed severe MR through the body of AML at A3. The percutaneous closure plan was to cross the AML perforation from the left ventricular side. The venacontracta of the perforation was 6 mm, an amplatzer septal occluder device 6 mm considered appropriate for closure of this hole. A snare catheter snared the wire and exteriorized creating arteriovenous loop. Amplatzer septal occluder 6 mm loaded to the delivery system till larger disc (left-sided) opened safely and freely below the MV apparatus. Once the left ventricular side disc opposed the ventricular surface of AML, the waist and left atrial disc gently released. The patient discharged in the next day. After 6 months, the patient had no more SOB, he returned to his daily activity. Follow-up TTE showed no MR, the closure device was stable in place.

Discussion
We added a successful case of transcatheter AML perforation to the literature. The role of TOE is crucial in diagnosis and procedure guidance.
Empire and information: the French Ministry of the Navy and Madagascar (1767–1819)
Authors: Tricoire Damien 
Published: July 2020

Abstract
This article discusses the question of how the history of administrative knowledge about distant world regions should be written. It analyses which intelligence was processed about Madagascar in the eighteenth century, and links the analysis of knowledge production about a specific world region with the colonial policy toward this region. A study of the texts written about Madagascar gives us insight into the ways the Ministry of the Navy ‘learned’ about the Indian Ocean colonies it took over from the Compagnie des Indes after the Seven Years War. This essay departs from the recent critique to the ‘colonial machine’ thesis, according to which the Ministry of the Navy could hardly take into consideration the great amount of information produced by officials in overseas. It contends that the commis of the Ministry did indeed read the letters from colonial officials, summarised their content for the minister, and proposed policies based on these information. However, while the propositions and claims of overseas officials clearly counted, this does not necessarily mean that the information received from overseas enabled the Minister of the Navy and their commis to design policies adapted to the reality on the spot. The case of writings about Madagascar shows why colonial policies might be built on wrong assumptions even when intelligence from overseas was taken into consideration. The article enhances particularly six factors that impacted information production: the degree of centralisation of the empire, the number of informers, patronage relationships, aristocratic sociabilities, the use of memoranda, and the Enlightenment.
Applying the proportionality principle to COVID-19 antibody testing
Authors: Gunnarsdóttir H D , Sinha M S , Gerke S , Minssen T 
Published: July 2020

Abstract
As the COVID-19 pandemic continues to ravage the globe, many nations have started to relax stringent restrictions in an effort to restart the economy. While Member States of the European Union have approached reopening without the use of antibody testing for COVID-19, such testing may be central to a long-term, sustainable strategy for international travel, employment, and the allocation and monitoring of vaccines. As the use of antibody testing to dictate the enjoyment of individual freedom remains highly controversial, we describe its use in the context of three case studies (return to the workplace, travel and vaccination), applying the substantive legal balancing entailed in the proportionality principle. Differential treatment of individuals based on COVID-19 antibody test results can be justified through the proportionality principle, which offers a sound dividing line between a reasonable and legitimate response and an unjust and discriminatory response.
Recurrent Spontaneous Pneumothorax in a 47-Year-Old Woman
Authors: Guenther Timothy M , Gustafson Joshua D , Pribyl Shea M , Wozniak Curtis J 
Published: July 2020

ABSTRACT
Pneumothorax is a condition where air exists in the chest cavity, outside the lung. The causes of pneumothorax are numerous and determining the etiology can aid in treatment and prevent recurrence. We describe a 47-year-old female patient with past medical history of endometriosis who presented to the emergency room with recurrent right sided pneumothorax, its onset correlating with onset of menses. She underwent video assisted thorascopic surgery for a suspected catamenial pneumothorax whereby nodular “chocolate” appearing areas were noted on the middle lobe and multiple similar appearing lesions and fenestrations were noted on the diaphragm. A biologic mesh was affixed to the diaphragm after which mechanical and chemical pleurodesis were performed. She tolerated the procedure well and has been symptom free since. Herein, we review the pathophysiology, diagnosis, and treatment strategies for catamenial pneumothorax in the hopes of increasing awareness and understanding of this rare cause of spontaneous pneumothorax.