bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrete-Time Fractional Order SIR Epidemic Model with Saturated Treatment Function
Authors: Abdelaziz Mahmoud A. M. , Izani Ismail Ahmad , Abdullah Farah A. , Hafiz Mohd Mohd 
Published: February 2020

Abstract
In this paper, a discrete-time fractional-order SIR epidemic model with saturated treatment function is investigated. The local asymptotic stability of the equilibrium points is analyzed and the threshold condition basic reproduction number is derived. Backward bifurcation is shown when the model possesses a stable disease-free equilibrium point and a stable endemic point coexisting together when the basic reproduction number is less than unity. It is also shown that when the treatment is partially effective, a transcritical bifurcation occurs at

ℜ

0

=
1

$\Re_{0}=1$

and reappears again when the effect of delayed treatment is getting stronger at

ℜ

0

<
1

$\Re_{0}<1$

. The analysis of backward and forward bifurcations associated with the transcritical, saddle-node, period-doubling and Neimark–Sacker bifurcations are discussed. Numerical simulations are carried out to illustrate the complex dynamical behaviors of the model. By carrying out bifurcation analysis, it is shown that the delayed treatment parameter ε should be less than two critical values ε
1 and ε
2 so as to avoid

ℜ

0

$\Re_{0}$

belonging to the dangerous range

ℜ

0

,
1

$\left[ \Re_{0},1\right]$

. The results of the numerical simulations support the theoretical analysis.
Teachers as agents of transformative pedagogy: Critical reflexivity, activism and multilingual spaces through a continua of biliteracy lens
Authors: Manan Syed Abdul 
Published: February 2020

AbstractLanguage policies and school practices in Pakistan continually perpetuate gaps between the traditionally less versus the traditionally more privileged languages. About 95% of students receive their primary and post-primary education in languages other than their L1. Drawing on the continua of biliteracy framework (Hornberger. 2003.Continua of biliteracy: An ecological framework for educational policy, research, and practice in multilingual settings. Clevedon: Multilingual Matters), this paper uses teachers’ experiential insights from upscale English-medium schools to show how they employ their critical reflexivity to resist the English-only school policy, and assert their agency to transform pedagogies into meaningful, contextualized, and multilingual modes. Theoretically, such agency and policy-from-below signifies that teachers/actors can creatively negotiate institutional/organizational policies creating substantive ideological and implementational spaces for multiple languages/cultures. Such initiatives also demonstrate that power is not always fixed in the hands of the few; rather critically conscious individuals can generate power to their own advantage. Teachers’ agency can effectively dismantle linguistic discrimination and undo the English-centric monolingualism. The reported opening of spaces for meaningful multilingual and contextualized voices carries useful lessons for those actors who might find their work settings limiting their agency and power. The study concludes that however minor the degree of agency and resistance may be in a particular context, these initiatives have the potential to transform normative perspectives about English and native/indigenous languages.
Crystal structure of bis(2-hydroxy-6-((phenylimino)methyl)phenolato-κ2
N,O)copper(II), C26H20CuN2O4
Authors: Olagboye Sulaiman A. , Yusuf Tunde L. , Oladipo Segun D. , Zamisa Sizwe J. 
Published: February 2020

Abstract
C26H20CuN2O4, triclinic, P1̄ (no. 2), a = 5.8633(1) Å, b = 12.2597(2) Å, c = 14.5517(3) Å, α = 82.960(1)°, β = 85.058(2)°, γ = 86.436(4)°, V = 1032.85(3) Å3, Z = 2, R
gt(F) = 0.0264, wR
ref(F
2) = 0.0732, T = 100(2) K.
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
Authors: Jacques Samuel , van der Sloot Almer M , C. Huard Caroline , Coulombe-Huntington Jasmin , Tsao Sarah , Tollis Sylvain , Bertomeu Thierry , Culp Elizabeth J , Pallant Daniel , Cook Michael A , Bonneil Eric , Thibault Pierre , Wright Gerard D , Tyers Mike 
Published: February 2020

Abstract
The imipridones ONC201 and ONC212 selectively kill cancer cells and have been ascribed multiple mechanisms-of-action. Genome-wide CRISPR knockout screens revealed that loss of the mitochondrial proteases CLPP and MIPEP confer strong resistance to both compounds...
Systematic genetic interaction profiles can reveal the mechanisms-of-action of bioactive compounds. The imipridone ONC201, which is currently in cancer clinical trials, has been ascribed a variety of different targets. To investigate the genetic dependencies of imipridone action, we screened a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout library in the presence of either ONC201 or its more potent analog ONC212. Loss of the mitochondrial matrix protease CLPP or the mitochondrial intermediate peptidase MIPEP conferred strong resistance to both compounds. Biochemical and surrogate genetic assays showed that impridones directly activate CLPP and that MIPEP is necessary for proteolytic maturation of CLPP into a catalytically competent form. Quantitative proteomic analysis of cells treated with ONC212 revealed degradation of many mitochondrial as well as nonmitochondrial proteins. Prompted by the conservation of ClpP from bacteria to humans, we found that the imipridones also activate ClpP from Escherichia coli, Bacillus subtilis, and Staphylococcus aureus in biochemical and genetic assays. ONC212 and acyldepsipeptide-4 (ADEP4), a known activator of bacterial ClpP, caused similar proteome-wide degradation profiles in S. aureus. ONC212 suppressed the proliferation of a number of Gram-positive (S. aureus, B. subtilis, and Enterococcus faecium) and Gram-negative species (E. coli and Neisseria gonorrhoeae). Moreover, ONC212 enhanced the ability of rifampin to eradicate antibiotic-tolerant S. aureus persister cells. These results reveal the genetic dependencies of imipridone action in human cells and identify the imipridone scaffold as a new entry point for antibiotic development.
Hidden, Unwanted or Simply Forgotten? A Bioarchaeological Profile of the Subačius Street 41 Population
Authors: Kozakaitė Justina , Miliauskienė Žydrūnė 
Published: February 2020

In 2014–2015, an unknown 16th–17th-century cemetery was discovered at the Subačius Street 41 plot in Vilnius. The uncovered human remains are considered to be one of the most abundant and best-preserved anthropological material in the territory of present-day Vilnius. Paradoxically, historical sources do not mention this burial site, although the abundance of the interred individuals does not imply an accidental burial, but perhaps a functioning cemetery for some time. In such exceptional cases, the only source of information is the synthesis of archaeological and anthropological research data.This article presents preliminary results and a brief overview of bioarchaeological (demographic, paleopathological, and dental research, height reconstruction) investigation. A total of 151 individuals were studied, with almost half (45%) of them consisting of children. Almost 60% of the individuals had one or more pathological lesions. The average height of male individuals was estimated 168.2 cm, the average height of females was 157.8 cm. The aim of this study can be defined as twofold: an attempt to identify the people buried outside the city walls and systematize for the first time the bioarchaeological data of one-out-of-many Vilnius populations. Currently, the Subačius Street 41 population does not resemble a typical urban community, so the study itself is the first attempt to reveal the osteobiography of these 16th–17th century Vilnius residents.
Tracheostomy in Very Low Birth Weight Infants: A Prospective Multicenter Study
Authors: Han Sam M. , Watters Karen F. , Hong Charles R. , Edwards Erika M. , Knell Jamie , Morrow Kate A. , Soll Roger F. , Jaksic Tom , Horbar Jeffrey D. , Modi Biren P. 
Published: February 2020

OBJECTIVES:
In this study, we benchmark outcomes and identify factors associated with tracheostomy placement in infants of very low birth weight (VLBW).

METHODS:
Data were prospectively collected on infants of VLBW (401–1500 g or gestational age of 22–29 weeks) born between 2006 and 2016 and admitted to 796 North American centers. Length of stay (LOS), mortality, associated surgical procedures, and comorbidities were assessed, and infants who received tracheostomy were compared with those who did not. Multivariable logistic regressions were performed to identify risk factors for tracheostomy placement and for mortality in those receiving tracheostomy.

RESULTS:
Of 458 624 infants of VLBW studied, 3442 (0.75%) received tracheostomy. Infants with tracheostomy had a median (interquartile range) LOS of 226 (168–304) days and a mortality rate of 18.8%, compared with 58 (39–86) days and 8.3% for infants without tracheostomy. Independent risk factors associated with tracheostomy placement included male sex, birth weight &lt;1001 g, African American non-Hispanic maternal race, chronic lung disease (CLD), intraventricular hemorrhage, patent ductus arteriosus ligation, and congenital neurologic, cardiac, and chromosomal anomalies. Among infants who received tracheostomy, male sex, birth weight &lt;751 g, CLD, and congenital anomalies were independent predictors of mortality.

CONCLUSIONS:
Infants of VLBW receiving tracheostomy had twice the risk of mortality and nearly 4 times the initial LOS of those without tracheostomy. CLD and congenital anomalies were the strongest predictors of tracheostomy placement and mortality. These benchmark data on tracheostomy in infants of VLBW should guide discussions with patient families and inform future studies and interventions.
Modification of Fourth order Runge-Kutta Method for Kutta Form With Geometric Means
Authors: Suryani Irma , Wartono Wartono , Muda Yuslenita 
Published: February 2020

This paper discuss how to modified Fourth order Runge-Kutta Kutta method based on the geometric mean. Then we have parameters and however by re-comparing the Taylor series expansion of and up to the 4th order. For make error term re-compering of the Taylor series expansion of and up to the 5th order. In the error term an make substitution for the values of and into the Taylor seriese expansion up to the 5th order. So that we have error term modified Fourth Order Runge-Kutta Kutta based on the geometric mean. Modified Fourth Order Runge-Kutta Kutta based on the geometric mean that usually used to solved ordinary differential equations.
Factores sociodemográficos maternos asociados con la lactancia materna exclusiva
Authors: Pinheiro Barbosa Késya Irene , Conceição Sueli Ismael Oliveira 
Published: February 2020

Introducción: La lactancia materna es esencial para el crecimiento y desarrollo adecuados del bebé debido a su composición energética y nutricional, a los factores inmunológicos y a su seguridad bajo los aspectos higiénicos y sanitarios. Objetivo: Dado lo anterior, este estudio tuvo como objetivo evaluar los factores sociodemográficos maternos asociados con la lactancia materna exclusiva. Materiales y Métodos: Estudio transversal realizado con 143 binomios madre-hijo menores de 24 meses de edad asistidos en cuatro Unidades Básicas de Salud de São Luís (MA). Se aplicó un primer formulario para recopilar datos socioeconómicos y demográficos de los binomios madre-hijo menores de 24 meses. El segundo formulario fue respondido por 75 madres con interrupción temprana de la lactancia materna exclusiva. Se evaluó la duración de la lactancia materna exclusiva, la atención prenatal y el posparto para las mujeres, el apoyo social en la lactancia materna y la influencia del uso de chupetes y biberones en la interrupción de la lactancia materna exclusiva. El Test Exacto de Fisher verificó la asociación entre las variables. Resultados: Se observó que el 33,3% de los niños mantuvieron la lactancia materna exclusiva hasta el sexto mes y su tiempo fue más largo (93.3%) entre quienes se beneficiaron de algún programa social. Discusión y Conclusiones: La baja frecuencia del tiempo de lactancia materna exclusiva en los niños mostró la necesidad de desarrollar estrategias para alentar la lactancia materna en la Atención Primaria de Salud, a fin de contribuir a la calificación de la atención nutricional y prenatal.
Como citar este artigo: Barbosa KIP, Conceição SIO. Fatores sociodemográficos maternos associados ao aleitamento materno exclusivo. Rev Cuid. 2020; 11(1): e811. http://dx.doi.org/10.15649/cuidarte.811
The Physical Fitness Gap between Strikers and Defenders in Football Extracurricular Programs
Authors: Darmawan Adriana Galih , Suharjana Suharjana 
Published: February 2020

This research can be categorized as a comparative descriptive study conducted through a survey to measure physical fitness. The subjects of this study were the students who joined the football extracurricular program in the State Junior High School 3 Sleman that consisted of 14 strikers and 23 defenders. The research instrument used the physical fitness test. The data analysis technique employed t-test analysis that required normality test and homogeneity test with 5% significance level. The results showed t count 3.956 with t table 2.027 (3.956 2.027). It means that there is a significant physical fitness difference between strikers and defenders in the football extracurricular program. The average physical fitness for strikers was 14.57, while the average physical fitness of defenders was 12.04. Based on the research findings, it can be concluded that there is a significant physical fitness difference between the strikers and the defenders in the football extracurricular program in the State Junior High School 3 Sleman
Improving Teaching Skills of the Prospective Physical Education Teachers through Drill Guide Method
Authors: Blegur Jusuf , Lumba Andreas J. F 
Published: February 2020

This study aimed at improving the teaching skills of prospective physical education teachers by using the drill guide method. The design used was Classroom Action Research from S. Kemmis and R. McTaggart involving 41 research subjects. Data for each cycle were taken by using teaching skill observation guidelines and in-depth interviews. The data were analysed descriptively. The improvement of the subjects’ teaching skills from the Pre Cycle to Cycle 1 was 86,4%, from Cycle 1 to Cycle 2 was 12,8%, and from Cycle 2 to Cycle 3 was 16,7%. The fastest improving item was to wear clean and neat clothes (3,95) and the slowest one was to relate the material to other fields of science (2,46). From the result, it can be concluded that the drill guide method is one of the best methods that can be applied when educators (lecturers or teachers) are giving a skill guidance.
A study of various hepatic manifestations in dengue fever and their correlation with severity of dengue fever
Authors: Dhanwada Shravya , R. Samba Siva Reddy 
Published: February 2020

Background: Hepatic involvement in Dengue is known with protean of manifestations ranging from hepatomegaly, elevated liver enzymes to fulminant hepatic failure. Aim of the study was to study the hepatic manifestations in children with dengue illness.Methods: This is a prospective Study with 60 Patients hospitalized with Dengue infection (Seropositive for Dengue). Dengue Seropositive patients are selected and examined for Hepatomegaly and Jaundice and subjected to complete blood count and Liver function tests were analysed.Results: Of 60 serologically confirmed cases hospitalized with dengue, were classified into (i)(DF), (ii) DHF I (iii) DHF II (iv) DHF III and (v) DHF IV. In our study, upon 60 seropositive cases were reported at our hospital during the study period of which 18 were DF, 12 were DHF I, 15 were DHFII, 8 were DHF III and 7 were DHF IV respectively. The Hematocrit levels were raised 20% from the baseline in four classes of Dengue and not raised in DF. Most commonly occurred in age group of 5-7 years. Hepatomegaly was the commonest clinical sign seen. Thrombocytopenia was seen in 88% of all cases. Serum total bilirubin was raised in 10% of subjects with severe dengue infection in DHF III and DHF IV. Serum SGOT and SGPT was raised in 63.3% and 56.7% of patients with dengue of all classes including DF respectively. Thrombocytopenia occurred in 75% of patients with dengue fever, 98% with warning signs and 100% in severe dengue.Conclusions: In developing country like India, incidence of dengue outbreaks is increasing. Hepatic involvement of varying degrees have been reported. As hepatic dysfunction in dengue is transient and reversible, early identification of the same would help to reduce life threatening complications. The role of hepato protective drugs in reducing morbidity and mortality should be analysed by further studies.
P wave axis and its correlation with severity of chronic obstructive pulmonary disease
Authors: R. Prasuna K. , Ratnam Praveena Korani , R. Pramod Kumar K. , V. K. Krishna Kumar T. 
Published: February 2020

Background: COPD can affect the heart as secondary effects of the disease. The electrocardiography has been seen as a very best tool for early diagnosis of any cardiac changes that may occur as a result of secondary effects of the chronic obstructive pulmonary disease. Objective of the study was to study the P wave axis and its correlation with severity of COPD.Methods: Here, 30 Patients of COPD confirmed by clinical history, examination and Pulmonary function tests were included in the study. These patients were clinically examined, and they underwent routine investigations like hemogram, urine examination, blood urea, serum creatinine, chest x-ray, random blood sugar, sputum examination and ABG analysis. These patients underwent pulmonary function test, ECG and ECHO.Results: In this study 36.66% of patients had RVH. Incomplete RBBB was seen in 20%. 13.33% had normal ECG. Most common finding in patients with less than one year of exposure was RVH. Low voltage complexes and R/S ratio in V1>1 were the only ECG changes with significant correlation with severity of the disease (p<0.05). Maximum no. of patients had a P wave axis of 71-800. the correlation between P wave axis and the duration of the disease was found to be statistically significant. the correlation between P wave axis and the severity of the disease was found to be statistically significant, 8/27 patients (29.63%) with less than one year of disease had features of corpulmonale.Conclusions: P-axis verticalization can serve as a very effective electrocardiographic screening tool for emphysema in the general population.
Spectrum of microbial infection in an Intensive Care Unit: a single centre tertiary care experience in Southern Indian state of Karnataka
Authors: S. Shruthi , Bhat Balachandra S. 
Published: February 2020

Background: There is an increased incidence of hospital acquired infection, especially in ICU setting, the most common being ICU acquired pneumonia which increases the morbidity, mortality, prolongs hospital stay and consuming more resources. Microbial etiology of intensive care unit (ICU)-acquired pneumonia (ICUAP) determines antibiotic treatment and outcomes which vary from centre to centre. Hence, a study of risk factors, clinical profile of patient, microorganisms and their resistance patterns to antibiotics are important for the diagnosis, prognosis of patient with ICU acquired pneumonia and also in the prevention of the same.Methods: Patients with ICUAP confirmed microbiologically were prospectively compared according to identification of 1 (monomicrobial) or more (polymicrobial) potentially pathogenic microorganism. Patients without microbiological confirmation were excluded from the study. We assessed clinical characteristics, microbiology and outcome variables.Results: In the present study 60 patients with ICU Pneumonia were included out of which 50 (83%) had mono-microbial infection. Most common organism isolated in mono microbial infection was Klebsiella species (26%), followed by Acinetobacter species (25%), out of which 20 percent was multidrug resistant. Multi-drug resistance was similarly frequent in both groups. Outcome variables like initial response to the empiric treatment, length of stay and mortality were similar in both monomicrobial and polymicrobial pneumonia. Mortality rates were higher with higher pneumonia scores (p value <0.002) and with multi organ dysfunction (p <0.008) irrespective of mono microbial or poly microbial infection.Conclusions: In this study mono microbial infection was more than polymicrobial, the most common organism being Kliebsiella species followed by Acinetobacter species. When empiric treatment is frequently appropriate, mortality rates were higher with higher pneumonia scores and MODS. In our study polymicrobial aetiology did not influence the outcome of ICUAP.
Intercultural Dialectic in Communication among Local Transmigrant Employees in Manggarai-Indonesia
Authors: . Fatmawati , Rosdiana Su Yosefina , Gunas Tobias , Helenora Jem Yosefina , Selamat Ely Heldydiana 
Published: February 2020

This research mainly focused on describing the intercultural dialectic in the interaction among local transmigrant employees in manggarai-NTT. The employees have multicultural background since they come from different regions in indonesia. A descriptive qualitative research design was used to understand the pattern of interaction among mother tongue of each employees, indonesian language, and other local languages that emerge the variation of language in their daily communication. In order to shed light on this issue, the factors that influence the use of the language variations were also significant to be considered. The research findings indicated that dialect maintenance, dialect adaptation, the occurrence of other languages, and the emergence of a unique dialect evolved. These patterns occurred due to some factors such as speech situation and topic, keeping the intimacy among the employers, language pride and as a marketing strategy.

Keywords: intercultural dialectic, language variation, local transmigrant employee.
Online News As Learning Resource in EFL Classrooms
Authors: Suteja Hanna 
Published: February 2020

Newspaper has been acknowledged as one useful learning resource in EFL classrooms. In this digital era teachers as well as learners can access unlimited resources on the internet; one of the resources available for free and at all times is online news. However, nowadays some students are not really keen on reading news and reading it in English is even more challenging. For this reason this study aims to bridge this gap. This research tries to find out in what way reading news on the same topics in both the Indonesian and English versions benefits EFL learners in terms of content and vocabulary. There were 98 Indonesian freshmen from three Reading classes taking part in this study. They read both the Indonesian and English news on the same topics as their reading assignment during the semester. At the end of the semester an online survey was conducted to find out the benefits of the assignment. A focused group interview was conducted to gain more information on the subjects’ responses in the survey. The findings show that reading both the Indonesian and English news on the same topics enhance the subjects’ understanding of the content of the English news as well as help them better guess the meaning of unknown English words and increase their vocabulary knowledge.

Keywords: online news, learning resource, EFL classrooms