bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling seasonal pasture growth and botanical composition at the paddock scale with satellite imagery
Authors: Ara Iffat , Harrison Matthew Tom , Whitehead Jason , Waldner François , Bridle Kerry , Gilfedder Louise , Marques da Silva José , Marques Francisco , Rawnsley Richard 
Published: December 2020

Abstract
Seasonal pasture monitoring can increase the efficiency of pasture utilization in livestock grazing enterprises. However, manual monitoring of pasture over large areas is often infeasible due to time and financial constraints. Here, we monitor changes in botanical composition in Tasmania, Australia, through application of supervised learning using satellite imagery (Sentinel-2). In the field, we measured ground cover and botanical composition over a 12-month period to develop a supervised classification approach used to identify pasture classes. Across seasons and paddocks, the approach predicted pasture classes with 75–81 % accuracy. Botanical composition varied seasonally in response to biophysical factors (primarily climate) and grazing behaviour, with seasonal highs in spring and troughs in autumn. Overall, we demonstrated that 10-m multispectral imagery can be reliably used to distinguish between pasture species as well as seasonal changes in botanical composition. Our results suggest that farmers and land managers should aim to quantify within-paddock variability rather than paddock average cover, because the extent and duration of very low ground cover puts the paddock/field at risk of adverse grazing outcomes, such as soil erosion and loss of pasture biomass, soil carbon and biodiversity. Our results indicate that satellite imagery can be used to support grazing management decisions for the benefit of pasture production and the improvement of environmental sustainability.
Pharmacokinetic/pharmacodynamic analysis of romidepsin used as an HIV latency reversing agent
Authors: Moltó José , Rosás-Umbert Miriam , Miranda Cristina , Manzardo Christian , Puertas Maria C , Ruiz-Riol Marta , López Miriam , Miró Jose M , Martinez-Picado Javier , Clotet Bonaventura , Brander Christian , Mothe Beatriz , Valle Marta 
Published: December 2020

AbstractObjectivesTo develop a population pharmacokinetic model for romidepsin given as an HIV latency reversing agent (LRA) and to explore the relationship between romidepsin exposure and its in vivo effects on viral gene expression and antiviral immunity.MethodsA population pharmacokinetic analysis was performed in 15 HIV-1-infected patients who received three weekly infusions of romidepsin (5 mg/m2) within the BCN02 clinical trial. A full pharmacokinetic profile was obtained for each participant at the first dose, and additional samples thereafter. A population pharmacokinetic model was developed. Bayesian estimates of the individual pharmacokinetic parameters of romidepsin were used to simulate individual time–concentration curves on each occasion. The relationship between romidepsin AUC0–∞ and its in vivo effects was assessed.ResultsRomidepsin pharmacokinetics were best described by a three-compartment model with linear kinetics. Body weight influenced romidepsin disposition. A significant relationship was observed between romidepsin AUC0–∞ and increases in expression of exhaustion markers by CD4+ and CD8+ T cells and apoptosis markers in CD4+, but not with histone acetylation levels or HIV-1 cell-associated RNA in CD4+ T cells. For each increase of 100 ng·h/mL in romidepsin AUC0–∞, CD4+ counts decreased by a mean (95% CI) of 74 (42–94) cells/mm3 after dosing.ConclusionsA population model describing the pharmacokinetics of romidepsin as an HIV LRA was developed. Higher exposure to romidepsin resulted in higher expression of apoptosis markers and declines in CD4+ count but did not increase viral reactivation levels. These observations have important implications for the optimization of effective kick-and-kill strategies for an HIV-1 cure.
Use of 3-nitrooxypropanol in a commercial feedlot to decrease enteric methane emissions from cattle fed a corn-based finishing diet
Authors: Alemu Aklilu W , Shreck Adam L , Booker Calvin W , McGinn Sean M , Pekrul Liana K D , Kindermann Maik , Beauchemin Karen A 
Published: December 2020

Abstract
The present study evaluated enteric CH4 production, dry matter (DM) intake (DMI), and rumen fermentation in feedlot cattle supplemented with increasing concentrations of 3-nitrooxypropanol (3-NOP). A total of 100 crossbred steers (body weight, 421 ± 11 kg) was randomly assigned to one of four treatments (n = 25/treatment): control (no 3-NOP) or low (100 mg/kg DM), medium (125 mg/kg DM), and high (150 mg/kg DM) doses of 3-NOP. The study was comprised of 28 d of adaptation followed by three 28-d periods, with CH4 measured for 7 d per period and cattle remaining on their respective diets throughout the 112-d study. Each treatment group was assigned to a pen, with the cattle and diets rotated among pens weekly to allow the animals to access the GreenFeed emission monitoring (GEM) system stationed in one of the pens for CH4 measurement. Measured concentration (mg/kg DM) of 3-NOP in the total diet consumed (basal diet + GEM pellet) was 85.6 for low, 107.6 for medium, and 124.5 for high doses of 3-NOP. There was a treatment × period interaction (P &lt; 0.001) for DMI; compared with control, the DMI was less for the low and high doses in period 1, with no differences thereafter. Compared with control (10.78 g/kg DMI), CH4 yield (g/kg DMI) was decreased (P &lt; 0.001) by 52%, 76%, and 63% for low, medium, and high doses of 3-NOP, respectively. A treatment × period effect (P = 0.048) for CH4 yield indicated that the low dose decreased in efficacy from 59% decrease in periods 1 and 2 to 37% decrease in period 3, while the efficacy of the medium and high doses remained consistent over time. Irrespective of dose, hydrogen emissions increased by 4.9-fold (P &lt; 0.001), and acetate:propionate ratio in rumen fluid decreased (P = 0.045) with 3-NOP supplementation, confirming that other hydrogen-utilizing pathways become more important in the CH4-inhibited rumen. The study indicates that supplementation of corn-based finishing diets with 3-NOP using a medium dose is an effective CH4 mitigation strategy for commercial beef feedlots with a 76% decrease in CH4 yield. Further research is needed to determine the effects of 3-NOP dose on weight gain, feed conversion efficiency, and carcass characteristics of feedlot cattle at a commercial scale.
Nuclear grade and comedo necrosis of ductal carcinoma in situ as histopathological eligible criteria for the Japan Clinical Oncology Group 1505 trial: an interobserver agreement study
Authors: Tsuda Hitoshi , Yoshida Masayuki , Akiyama Futoshi , Ohi Yasuyo , Kinowaki Keiichi , Kumaki Nobue , Kondo Yuzuru , Saito Akihisa , Sasaki Eiichi , Nishimura Rieko , Fujii Satoshi , Homma Keiichi , Horii Rie , Murata Yuya , Itami Makiko , Kajita Sabine , Kato Hiroyuki , Kurosumi Masafumi , Sakatani Takashi , Shimizu Shigeki , Taniguchi Kohei , Tamiya Sadafumi , Nakamura Harumi , Kanbayashi Chizuko , Shien Tadahiko , Iwata Hiroji 
Published: December 2020

Abstract

Objective
The Japan Clinical Oncology Group 1505 trial is a single-arm multicentre prospective study that examined the possibility of non-surgical follow-up with endocrine therapy for patients with low-grade ductal carcinoma in situ. In that study, the eligible criteria included histopathological findings comprising low to intermediate nuclear grade and absence of comedo necrosis, and cases were entered according to the local histopathological diagnosis. Nuclear grade is largely based on the Consensus Conference criteria (1997), whereas comedo necrosis is judged according to the Rosen’s criteria (2017). The purpose of this study was to standardize and examine the interobserver agreement levels of these histopathological criteria amongst the participating pathologists.

Methods
We held slide conferences, where photomicrographs of haematoxylin–eosin-stained slides from 68 patients with ductal carcinoma in situ were presented using PowerPoint. The nuclear grade and comedo necrosis statuses individually judged by the pathologists were analysed using κ statistics.

Results
In the first and second sessions, where 22 cases each were presented, the interobserver agreement levels of nuclear grade whether low/intermediate grade or high grade were moderate amongst 29 and 24 participating pathologists, respectively (κ = 0.595 and 0.519, respectively). In the third session where 24 cases were presented, interobserver agreement levels of comedo necrosis or non-comedo necrosis were substantial amongst 25 participating pathologists (κ = 0.753).

Conclusion
Although the concordance rates in nuclear grade or comedo necrosis were not high in a few of the cases, we believe that these results could provide a rationale for employing the present criteria of nuclear grade and comedo necrosis in the clinical study of ductal carcinoma in situ.
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Authors: Hardenberg Maarten C , Sinnige Tessa , Casford Sam , Dada Samuel , Poudel Chetan , Robinson Elizabeth A , Fuxreiter Monika , Kaminksi Clemens , Kaminski-Schierle Gabriele S , Nollen Ellen A A , Dobson Christopher M , Vendruscolo Michele 
Published: December 2020

Abstract
Misfolded α-synuclein is a major component of Lewy bodies, which are a hallmark of Parkinson’s disease. A large body of evidence shows that α-synuclein can aggregate into amyloid fibrils, but the relationship between α-synuclein self-assembly and Lewy body formation remains unclear. Here we show, both in vitro and in a Caenorhabditis elegans model of Parkinson’s disease, that α-synuclein undergoes liquid‒liquid phase separation by forming a liquid droplet state, which converts into an amyloid-rich hydrogel with Lewy-body-like properties. This maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in vitro. Taken together, these results suggest that the formation of Lewy bodies may be linked to the arrested maturation of α-synuclein condensates in the presence of lipids and other cellular components.
Discovery and Surveillance of Tick-Borne Pathogens
Authors: Tokarz Rafal , Lipkin W Ian 
Published: December 2020

AbstractWithin the past 30 yr molecular assays have largely supplanted classical methods for detection of tick-borne agents. Enhancements provided by molecular assays, including speed, throughput, sensitivity, and specificity, have resulted in a rapid increase in the number of newly characterized tick-borne agents. The use of unbiased high throughput sequencing has enabled the prompt identification of new pathogens and the examination of tick microbiomes. These efforts have led to the identification of hundreds of new tick-borne agents in the last decade alone. However, little is currently known about the majority of these agents beyond their phylogenetic classification. Our article outlines the primary methods involved in tick-borne agent discovery and the current status of our understanding of tick-borne agent diversity.
Religious Accommodation in Bioethics and the Practice of Medicine
Authors: Smith William R , Audi Robert 
Published: December 2020

AbstractDebates about the ethics of health care and medical research in contemporary pluralistic democracies often arise partly from competing religious and secular values. Such disagreements raise challenges of balancing claims of religious liberty with claims to equal treatment in health care. This paper proposes several mid-level principles to help in framing sound policies for resolving such disputes. We develop and illustrate these principles, exploring their application to conscientious objection by religious providers and religious institutions, accommodation of religious priorities in biomedical research, and treatment of patients’ religious views in doctor–patient encounters. Given that no sound set of guiding principles yields precise solutions for every policy dispute, we explore how morally sound democracies might deliberatively resolve such policy issues, following our proposed principles. Taken together and carefully interpreted, these principles may help in guiding difficult decision making in the indefinitely large realm where government, medical providers, and patients encounter problems concerning religion and medicine.
Effect of Personalized Breast Cancer Risk Tool on Chemoprevention and Breast Imaging: ENGAGED-2 Trial
Authors: Wernli Karen J , Knerr Sarah , Li Tengfei , Leppig Kathleen , Ehrlich Kelly , Farrell David , Gao Hongyuan , Bowles Erin J A , Graham Amanda L , Luta George , Jayasekera Jinani , Mandelblatt Jeanne S , Schwartz Marc D , O’Neill Suzanne C 
Published: December 2020

AbstractBackgroundLimited evidence exists about how to communicate breast density-informed breast cancer risk to women at elevated risk to motivate cancer prevention.MethodsWe conducted a randomized controlled trial evaluating a web-based intervention incorporating personalized breast cancer risk, information on chemoprevention, and values clarification on chemoprevention uptake vs active control. Eligible women aged 40-69 years with normal mammograms and elevated 5-year breast cancer risk were recruited from Kaiser Permanente Washington from February 2017 to May 2018. Chemoprevention uptake was measured as any prescription for raloxifene or tamoxifen within 12 months from baseline in electronic health record pharmacy data. Secondary outcomes included breast magnetic resonance imaging (MRI), mammography use, self-reported distress, and communication with providers. We calculated unadjusted odds ratios (ORs) using logistic regression models and mean differences using analysis of covariance models with 95% confidence intervals (CIs) with generalized estimating equations.ResultsWe randomly assigned 995 women to the intervention arm (n = 492) or control arm (n = 503). The intervention (vs control) had no effect on chemoprevention uptake (OR = 1.04, 95% CI = 0.07 to 16.62). The intervention increased breast MRI use (OR = 5.65, 95% CI = 1.61 to 19.74) while maintaining annual mammography (OR = 0.98, 95% CI = 0.75 to 1.28). Women in the intervention (vs control) arm had 5.67-times higher odds of having discussed chemoprevention or breast MRI with provider by 6 weeks (OR = 5.67, 95% CI = 2.47 to 13.03) and 2.36-times higher odds by 12 months (OR = 2.36, 95% CI = 1.65 to 3.37). No measurable differences in distress were detected.ConclusionsA web-based, patient-level intervention activated women at elevated 5-year breast cancer risk to engage in clinical discussions about chemoprevention, but uptake remained low.
Chylous ascites following elective abdominal aortic aneurysm repair
Authors: Bowden Sylvie , Firdouse Mohammed , Roche-Nagle Graham 
Published: December 2020

Abstract
Postoperative chylous ascites is a rare complication of abdominal surgery. Chyle depletion results in nutritional, immunologic and metabolic deficiencies, making it a serious and potentially life-threatening condition for which prompt diagnosis and management is imperative. A 72-year-old male was referred for open repair of a 62 cm juxtarenal abdominal aortic aneurysm (AAA). Following resumption of diet, he developed abdominal distention. Therapeutic paracenteses confirmed chylous ascites. Failed conservative management and lymphatic embolization lead to surgical sealance of lymphatic leak using glue. Postoperatively, a full diet was tolerated with no further ascites. Paracentesis is the diagnostic modality of choice in evaluating patients with ascites. Management is challenging and should be multifaceted and tailored to individual patient needs. Cornerstones of therapy include correction of the underlying etiology and conservative measures. When conservative measures fail, other interventions can be considered, such as somatostatin analogs, surgical ligation or glue embolization.
Bilateral traumatic distal femoral transphyseal fracture in a 9-year-old male
Authors: Davis Timothy P , Mehta Rujuta , Agrawal Arpit 
Published: December 2020

Abstract
A case of bilateral traumatic distal femoral Salter-Harris Type I fracture presented to our emergency department. History was of a 9-year-old male playing at a building site when a concrete block fell from height on to his knees, which were extended in a sitting position. Management was with analgesia and transfer to theatre followed by closed reduction and internal fixation—position was assessed under mobile X-ray. The patient made a full clinical recovery within 18 weeks and was followed-up over 5 years. There was no clinical effect on final adult length of femur and no deficit in range of movement. The foot-drop observed at presentation resolved over a period of 12 weeks. This case highlights the importance of performing a thorough neurovascular examination of the patient at presentation, followed by a careful closed reduction and internal fixation under anaesthesia, being careful not to damage the distal femoral growth plates.
Access-based intuitionistic knowledge
Authors: Lewitzka Steffen 
Published: December 2020

AbstractWe introduce the concept of $\textit{access-based}$ intuitionistic knowledge which relies on the intuition that agent $i$ knows $\varphi$ if $i$ has found $\textit{access to a proof}$ of $\varphi$. Basic principles are distribution and factivity of knowledge as well as $\square\varphi\rightarrow K_i\varphi$ and $K_i(\varphi\vee\psi) \rightarrow (K_i\varphi\vee K_i\psi)$, where $\square\varphi$ reads $`\varphi$ is proved'. The formalization extends a family of classical modal logics (Lewitzka, 2017, Journal of Logic and Computation, 27, 201--212) designed as combinations of $\mathit{IPC}$ and $\mathit{CPC}$ and as systems for the reasoning about proof, i.e. intuitionistic truth. We adopt a formalization of common knowledge from (Lewitzka, 2011, Studia Logica, 97, 233--264) and interpret it here as access-based common knowledge. We compare our proposal with recent approaches to intuitionistic knowledge (Artemov and Protopopescu, 2016, The Review of Symbolic Logic, 9, 266--298; Lewitzka, 2019, Annals of Pure and Applied Logic, 170, 218--250) and bring together these different concepts in a unifying semantic framework based on Heyting algebra expansions.
Greater Severity and Functional Impact of Post-traumatic Headache in Veterans With Comorbid Neck Pain Following Traumatic Brain Injury
Authors: Shahidi Bahar , Bursch Robyn W , Carmel Jennifer S , Carranza Ashleigh C , Cooper Kelsey M , Lee Jayme V , O’Connor Colleen N , Sorg Scott F , Maluf Katrina S , Schiehser Dawn M 
Published: December 2020

ABSTRACT

Background
Post-traumatic headache (PTH) is a commonly experienced symptom after mild traumatic brain injury (mTBI). Blast injury– or blunt injury–related mechanisms for mTBI in veterans can also affect musculoskeletal structures in the neck, resulting in comorbid neck pain (NP). However, it is unknown whether the presence of comorbid NP may be associated with a different pattern of headache symptoms, physical functioning, or emotional functioning compared to those without comorbid NP. The purpose of this study is to examine the role of comorbid NP in veterans with mTBI and PTH.

Design and Methods
This was a cross-sectional investigation of an existing dataset that included 33 veterans who met inclusion criteria for PTH after mTBI. Standardized measures of headache severity and frequency, insomnia, fatigue, mood disorders, and physical and emotional role function were compared between groups with and without comorbid NP.

Results
The majority of participants with PTH reported comorbid NP (n = 22/33, 67%). Those with comorbid NP experienced more headache symptoms that were severe or incapacitating, as compared to mild or moderate for those without NP (φ = 0.343, P = .049); however, no differences in headache frequency (φ = 0.231, P = .231) or duration (φ = 0.129, P = .712) were observed. Participants with comorbid NP also reported greater insomnia (d = 1.16, P = .003) and fatigue (d = 0.868, P = .040) as well as lower physical functioning (d = 0.802, P = .036) and greater bodily pain (d = 0.762, P = .012). There were no differences in anxiety, depression, mental health, emotional role limitations, vitality, or social functioning between those with and without comorbid NP (d ≤ 0.656, P ≥ .079).

Conclusions
A majority of veterans with mTBI and PTH in our sample reported comorbid NP that was associated with greater headache symptom severity and physical limitations, but not with mood or emotional limitations. Preliminary findings from this small convenience sample indicate that routine assessment of comorbid NP and associated physical limitations should be considered in veterans with mTBI and PTH.
Exploring the link between C iv outflow kinematics and sublimation-temperature dust in quasars
Authors: Temple Matthew J , Banerji Manda , Hewett Paul C , Rankine Amy L , Richards Gordon T 
Published: December 2020

ABSTRACT
Using data from SDSS, UKIDSS, and WISE, we investigate the properties of the high-frequency cutoff to the infrared emission in ≃5000 carefully selected luminous (Lbol ∼ 1047) type 1 quasars. The strength of ≃2 μm emission, corresponding to emission from the hottest ($T\gt 1200\rm \, K$) dust in the sublimation zone surrounding the central continuum source, is observed to correlate with the blueshift of the C iv λ1550 emission line. We therefore find that objects with stronger signatures of nuclear outflows tend to have a larger covering fraction of sublimation-temperature dust. When controlling for the observed outflow strength, the hot dust covering fraction does not vary significantly across our sample as a function of luminosity, black hole mass, or Eddington fraction. The correlation between the hot dust and the C iv line blueshifts, together with the lack of correlation between the hot dust and other parameters, therefore provides evidence of a link between the properties of the broad emission line region and the infrared-emitting dusty regions in quasars.
A homogeneous measurement of the delay between the onsets of gas stripping and star formation quenching in satellite galaxies of groups and clusters
Authors: Oman Kyle A , Bahé Yannick M , Healy Julia , Hess Kelley M , Hudson Michael J , Verheijen Marc A W 
Published: December 2020

ABSTRACT
We combine orbital information from N-body simulations with an analytic model for star formation quenching and SDSS observations to infer the differential effect of the group/cluster environment on star formation in satellite galaxies. We also consider a model for gas stripping, using the same input supplemented with H i fluxes from the ALFALFA survey. The models are motivated by and tested on the Hydrangea cosmological hydrodynamical simulation suite. We recover the characteristic times when satellite galaxies are stripped and quenched. Stripping in massive ($M_{\rm vir}\sim 10^{14.5}\, {\rm M}_\odot$) clusters typically occurs at or just before the first pericentric passage. Lower mass ($\sim 10^{13.5}\, {\rm M}_\odot$) groups strip their satellites on a significantly longer (by $\sim 3\, {\rm Gyr}$) time-scale. Quenching occurs later: Balmer emission lines typically fade $\sim 3.5\, {\rm Gyr}$ ($5.5\, {\rm Gyr}$) after first pericentre in clusters (groups), followed a few hundred Myr later by reddenning in (g − r) colour. These ‘delay time-scales’ are remarkably constant across the entire satellite stellar mass range probed (∼109.5–$10^{11}\, {\rm M}_\odot$), a feature closely tied to our treatment of ‘group pre-processing’. The lowest mass groups in our sample ($\sim 10^{12.5}\, {\rm M}_\odot$) strip and quench their satellites extremely inefficiently: typical time-scales may approach the age of the Universe. Our measurements are qualitatively consistent with the ‘delayed-then-rapid’ quenching scenario advocated for by several other studies, but we find significantly longer delay times. Our combination of a homogeneous analysis and input catalogues yields new insight into the sequence of events leading to quenching across wide intervals in host and satellite mass.