bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic factors associated with food insecurity: data from the 2003–2014 New South Wales Population Health Survey
Authors: Drakoulidou Paraskevi , Drayton Bradley , Shepherd Leah , Mihrshahi Seema 
Published: May 2020

AbstractObjective:To determine the prevalence and sociodemographic factors associated with food insecurity in the state of New South Wales (NSW), Australia.Design:Cross-sectional analysis of food insecurity data collected by the NSW Population Health Survey between 2003 and 2014. Multiple logistic regression was used to examine associations with key sociodemographic variables.Setting:NSW, Australia.Participants:212 608 survey participants responded to the food insecurity survey question between 2003 and 2014. 150 767 of them were aged ≥16 years. The survey sample was randomly selected and weighted to be representative of the NSW population.Results:On average 6 % of adults aged ≥16 years experienced food insecurity in NSW. The odds of food insecurity appeared to increase from one survey year to the next by a factor of 1·05. Food insecurity was found to be independently associated with age, sex, marital status, household size, education, employment status, household income, smoking status, alcohol intake and self-rated health. The association with income, smoking status and self-rated health appeared to be the strongest among all covariates and showed a gradient effect. Food insecurity appeared to increase significantly between the age of 16 and 19 years.Conclusions:The prevalence of food insecurity appears to be rising over time. Given the negative health consequences of food insecurity, more rigorous measurement and monitoring of food insecurity in NSW and nationally is strongly recommended. The findings provide support for interventions targeting low-income and younger population groups.
Protein intake pattern over the day and its association with low total protein intake in Dutch community-dwelling older adults
Authors: Rooijackers Teuni H , Ocké Marga C , Hengeveld Linda M , Visser Marjolein , Boer Jolanda MA 
Published: May 2020

AbstractObjective:Investigate protein intake patterns over the day and their association with total protein intake in older adults.Design:Cross-sectional study utilising the dietary data collected through two non-consecutive, dietary record-assisted 24-h recalls. Days with low protein intake (n 290) were defined using the RDA (<0·8 g protein/kg adjusted BW/d). For each day, the amount and proportion of protein ingested at every hour of the day and during morning, mid-day and evening hours was calculated. Amounts and proportions were compared between low and high protein intake days and related to total protein intake and risk of low protein intake.Setting:Community.Participants:739 Dutch community-dwelling adults ≥70 years.Results:The mean protein intake was 76·3 (sd 0·7) g/d. At each hour of the day, the amount of protein ingested was higher on days with a high protein intake than on days with a low protein intake and associated with a higher total protein intake. The proportion of protein ingested during morning hours was higher (22 v. 17 %, P < 0·0001) on days with a low protein intake, and a higher proportion of protein ingested during morning hours was associated with a lower total protein intake (P < 0·0001) and a higher odds of low protein intake (OR 1·04, 95 % CI 1·03, 1·06). For the proportion of protein intake during mid-day or evening hours, opposite but weaker associations were found.Conclusions:In this sample, timing of protein intake was associated with total protein intake. Additional studies need to clarify the importance of these findings to optimise protein intake.
Associations between major dietary patterns and anxiety in middle-aged adults in eastern China
Authors: Xu Feng , Chong Bao-Qiang , Cai Tong , Zhang Jin-Ling , Lv Jing 
Published: May 2020

AbstractObjective:The current study aimed to evaluate the association of major dietary patterns with anxiety in middle-aged adults in eastern China.Design:Dietary intake was assessed using a semi-quantitative FFQ. Binary logistic regression analysis was used to estimate OR and 95 % CI for anxiety according to quartiles of each dietary pattern score.Setting:Evidence regarding the relationship between dietary patterns and anxiety in the Chinese population is scarce.Participants:The study participants were 1360 Chinese adults aged 45–59 years, who participated in a health survey at the time of periodic check-up in the city of Linyi, Shandong Province, China.Results:Four major dietary patterns were identified by factor analysis: traditional Chinese, western, grains–vegetables and high-salt diets. After adjusting for potential confounders, participants in the highest quartile of the western pattern had greater odds for anxiety, compared with those in the lowest quartile (OR 1·35, 95 % CI 1·000, 3·086, P < 0·05). In contrast, participants in the highest quartile of the grains–vegetables pattern had lower odds for anxiety than did those in the lowest quartile (OR 0·78, 95 % CI 0·574, 1·000, P < 0·05). Moreover, no significant associations were observed between the traditional Chinese and high-salt patterns and the risk of anxiety.Conclusions:Our findings indicate that the western pattern is associated with an increased risk, and the grains–vegetables pattern is associated with a decreased risk of anxiety.
Unfinished narratives. Some remarks on the archaeology of the contemporary past in Iran
Authors: Dezhamkhooy Maryam , Papoli-Yazdi Leila 
Published: May 2020

AbstractThis paper discusses the emergence of an archaeology of the contemporary era in a Middle Eastern country, Iran. Far from North America and Europe, where the subfield was introduced, appreciated and developed by academic archaeologists, this archaeology is now also becoming established in Iran in spite of academic reluctance and (indirect) political pressure. The most encouraged form of archaeology in Iran remains nationalist and conservative, supported by the current political structures. However, the archaeology of the contemporary past is increasingly practised on a limited scale and has gradually extended its scope and subjects. Highly dependent on context, it has enriched the ways and methods of archaeological practice under dictatorship. The archaeology of the contemporary past is still in its infancy in the Middle East, but the pioneers of the subfield try to take up the challenges of smoothing the way for the future of this interdisciplinary archaeology in Iran and the Middle East. Iranian contemporary archaeology not only aims to investigate conflict, tensions and political (and armed) opposition, but also studies everyday life and disastrous contexts.
The relationship between caregivers’ perceptions of end-of-life care in long-term care and a good resident death
Authors: Lee Eunyoung , Sussman Tamara , Kaasalainen Sharon , Durepos Pamela , McCleary Lynn , Wickson-Griffiths Abigail , Bimman Rennie 
Published: May 2020

AbstractObjectiveQuality end-of-life (EOL) care is critical for dying residents and their family/friend caregivers. While best practices to support resident comfort at EOL in long-term care (LTC) homes are emerging, research rarely explores if and how the type of care received at EOL may contribute to caregivers’ perceptions of a good death. To address this gap, this study explored how care practices at EOL contributed to caregivers’ perceptions of a good resident death.MethodThis study used a retrospective cross-sectional survey design. Seventy-eight participants whose relative or friend died in one of five LTC homes in Canada completed self-administered questionnaires on their perceptions of EOL care and perceptions of a good resident death.ResultsOverall, caregivers reported positive experiences with EOL care and perceived residents to have died a good death. However, communication regarding what to expect in the final days of life and attention to spiritual issues were often missing components of care. Further, when explored alongside direct resident care, family support, and rooming conditions, staff communication was the only aspect of EOL care significantly associated with caregivers’ perceptions of a good resident death.Significance of resultsThe findings of this study suggest that the critical role staff in LTC play in supporting caregivers’ perceptions of a good resident death. By keeping caregivers informed about expectations at the very end of life, staff can enhance caregivers’ perceptions of a good resident death. Further, by addressing spiritual issues staff may improve caregivers’ perceptions that residents were at peace when they died.
Comparative clinical trials in psychotherapy: Have large effects been replicated?
Authors: Frost Nickolas D. , Baskin Thomas W. , Wampold Bruce E. 
Published: May 2020

Abstract

Aims
The purpose of this review is to examine the replication attempts of psychotherapy clinical trials for depression and anxiety. We focus specifically on replications of trials that exhibit large differences between psychotherapies. The replicability of these trials is especially important for meta-analysis, where the inclusion of false-positive trials can lead to erroneous conclusions about treatment efficacy.

Methods
Standard replication criteria were developed to distinguish direct from conceptual replication methodologies. Next, an exhaustive literature search was conducted for published meta-analyses of psychotherapy comparisons. Trials that exhibited large effects (d > 0.8) were culled from these meta-analyses. For each trial, a cited replication was conducted to determine if the trial had been subsequently replicated by either ‘direct’ or ‘conceptual’ methods. Finally, a broader search was conducted to examine the extent of replication efforts in the psychotherapy literature overall.

Results
In the meta-analytic search, a total of N = 10 meta-analyses met the inclusion criteria. From these meta-analyses, N = 12 distinct trials exhibited large effect sizes. The meta-analyses containing more than two large effect trials reported evidence for treatment superiority. A cited replication search yielded no direct replication attempts (N = 0) for the trials with large effects, and N = 4 conceptual replication attempts of average or above average quality. However, of these four attempts, only two partially corroborated the results from their original trial.

Conclusion
Meta-analytic reviews are influenced by trials with large effects, and it is not uncommon for these reviews to contain several such trials. Since we find no evidence that trials with such large effects are directly replicable, treatment superiority conclusions from these reviews are highly questionable. To enhance the quality of clinical science, the development of authoritative replication criteria for clinical trials is needed. Moreover, quality benchmarks should be considered before trials are included in a meta-analysis, or replications are attempted.
A Study of a Magnetic Cloud Propagating Through Large‐Amplitude Alfvén Waves
Authors: Farrugia C. J. , Lugaz N. , Vasquez B. J. , Wilson L. B. , Yu W. , Paulson K. , Torbert R. B. , Gratton F. T. 
Published: May 2020

AbstractWe discuss Wind observations of a long and slow magnetic cloud (MC) propagating through large‐amplitude Alfvén waves (LAAWs). The MC axis has a strong component along GSE X, as also confirmed by a Grad‐Shafranov reconstruction. It is overtaking the solar wind at a speed roughly equal to the upstream Alfvén speed, leading to a weak shock wave 17 hr ahead. We give evidence to show that the nominal sheath region is populated by LAAWs: (i) a well‐defined de Hoffmann‐Teller frame in which there is excellent correlation between the field and flow vectors, (ii) constant field and total pressure, and (iii) an Alfvén ratio (i.e., ratio of kinetic‐to‐magnetic energy of the fluctuations) near unity at frequencies much lower than the ion cyclotron frequency in the spacecraft frame. In the region where the LAAWs approach the MC's front boundary there are field and flow discontinuities. At the first, magnetic reconnection is taking place, as deduced from a stress balance test (Walén test). This severs connection of some field lines to the Sun and the solar wind strahl disappears. There follows a 2‐hr interval where the magnetic field strength is diminished while pressure balance is maintained. Here the bidirectionality of the suprathermal electron flows is intermittently disrupted. This interval ends with a slow expansion fan downstream of which there is a dropout of halo electrons just inside the front boundary of the MC. This study illustrates an untypical case of a slow MC interacting with LAAWs in the slow solar wind.
mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use
Authors: Cox Sylvia M. L. , Tippler Maria , Jaworska Natalia , Smart Kelly , Castellanos-Ryan Natalie , Durand France , Allard Dominique , Benkelfat Chawki , Parent Sophie , Dagher Alain , Vitaro Frank , Boivin Michel , Pihl Robert O. , Côté Sylvana , Tremblay Richard E. , Séguin Jean R. , Leyton Marco 
Published: May 2020

AbstractThe excitatory neurotransmitter glutamate has been implicated in experience-dependent neuroplasticity and drug-seeking behaviors. Type 5 metabotropic glutamate (mGlu5) receptors might be particularly important. They are critically involved in synaptic plasticity and their availability has been reported to be lower in people with alcohol, tobacco, and cocaine use disorders. Since these reductions could reflect effects of drug use or pre-existing traits, we used positron emission tomography to measure mGlu5 receptor availability in young adults at elevated risk for addictions. Fifty-nine participants (age 18.5 ± 0.6) were recruited from a longitudinal study that has followed them since birth. Based on externalizing traits that predict future substance use problems, half were at low risk, half were at high risk. Cannabis use histories varied markedly and participants were divided into three subgroups: zero, low, and high use. Compared to low risk volunteers, those at elevated risk had lower [11C]ABP688 binding potential (BPND) values in the striatum, amygdala, insula, and orbitofrontal cortex (OFC). Cannabis use by risk group interactions were observed in the striatum and OFC. In these regions, low [11C]ABP688 BPND values were only seen in the high risk group that used high quantities of cannabis. When these high risk, high cannabis use individuals were compared to all other participants, [11C]ABP688 BPND values were lower in the striatum, OFC, and insula. Together, these results provide evidence that mGlu5 receptor availability is low in youth at elevated risk for addictions, particularly those who frequently use cannabis.
Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis
Authors: Tian Chunjie , Kim Yeon Ju , Hali Sai , Choo Oak-Sung , Lee Jin-Sol , Jung Seo-Kyung , Choi Youn-Uk , Park Chan Bae , Choung Yun-Hoon 
Published: May 2020

AbstractAge-dependent decrease of mitochondrial energy production and cellular redox imbalance play significant roles in age-related hearing loss (ARHL). Lactate dehydrogenase B (LDHB) is a key glycolytic enzyme that catalyzes the interconversion of pyruvate and lactate. LDH activity and isoenzyme patterns are known to be changed with aging, but the role of LDHB in ARHL has not been studied yet. Here, we found that LDHB knockout mice showed hearing loss at high frequencies, which is the typical feature of ARHL. LDHB knockdown caused downregulation of mitochondrial functions in auditory cell line, University of Bristol/organ of Corti 1 (UB/OC1) with decreased NAD+ and increased hypoxia inducing factor-1α. LDHB knockdown also enhanced the death of UB/OC1 cells with ototoxic gentamicin treatment. On the contrary, the induction of LDHB expression caused enhanced mitochondrial functions, including changes in mitochondrial respiratory subunits, mitochondrial membrane potentials, ATP, and the NAD+/NADH ratio. Thus, we concluded that suppression of LDHB activity may be closely related with the early onset or progression of ARHL.
BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis
Authors: Liu Lixin , Zhang Sulin , Wang Yirui , Bao Weilian , Zhou Yile , Dang Wenzhen , Wang Xu , Li Haidong , Cao Xinyue , You Yan , Fang Hao , Shen Xiaoyan 
Published: May 2020

AbstractSepsis is caused by a dysregulated host inflammatory response to serious infections resulting in life-threatening organ dysfunction. The high morbidity and mortality make sepsis still a major clinical problem. Here, we investigated the roles of Brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1) in the pathogenesis process of sepsis and the underlying mechanisms. We found myeloid cell-specific BIG1 knockout (BIG1 cKO) significantly reduced the mortality and organ damage in LPS-induced and CLP-induced polymicrobial sepsis mouse model. The serum concentration and mRNA expression of pro-inflammatory cytokines including TNF-α, IL-6, IL-1β, and IL-12 were obviously decreased in BIG1 cKO mice. In bone marrow-derived macrophages or THP-1 cells, BIG1 deficiency caused an inhibited ARF3 activation, which reduced PI(4,5)P2 synthesis and the recruitment of TIRAP to the plasma membrane through inhibiting the activation of PIP5K induced by LPS, and eventually resulted in the inhibitory activity of TLR4-MyD88 signaling pathway. These results reveal a crucial new role of BIG1 in regulating macrophage inflammation responses, and provide evidence for BIG1 as a potential promising therapeutic target in sepsis.
Distributed acoustic sensing of microseismic sources and wave propagation in glaciated terrain
Authors: Walter F. , Gräff D. , Lindner F. , Paitz P. , Köpfli M. , Chmiel M. , Fichtner A. 
Published: May 2020

AbstractRecords of Alpine microseismicity are a powerful tool to study landscape-shaping processes and warn against hazardous mass movements. Unfortunately, seismic sensor coverage in Alpine regions is typically insufficient. Here we show that distributed acoustic sensing (DAS) bridges critical observational gaps of seismogenic processes in Alpine terrain. Dynamic strain measurements in a 1 km long fiber optic cable on a glacier surface produce high-quality seismograms related to glacier flow and nearby rock falls. The nearly 500 cable channels precisely locate a series of glacier stick-slip events (within 20–40 m) and reveal seismic phases from which thickness and material properties of the glacier and its bed can be derived. As seismic measurements can be acquired with fiber optic cables that are easy to transport, install and couple to the ground, our study demonstrates the potential of DAS technology for seismic monitoring of glacier dynamics and natural hazards.
Exposure to UV radiance predicts repeated evolution of concealed black skin in birds
Authors: Nicolaï Michaël P. J. , Shawkey Matthew D. , Porchetta Sara , Claus Ruben , D’Alba Liliana 
Published: May 2020

AbstractPlumage is among the most well-studied components of integumentary colouration. However, plumage conceals most skin in birds, and as a result the presence, evolution and function of skin colour remains unexplored. Here we show, using a database of 2259 species encompassing >99% of bird genera, that melanin-rich, black skin is found in a small but sizeable percentage (~5%) of birds, and that it evolved over 100 times. The spatial distribution of black skin follows Gloger’s rule, which states that pigmentation of endothermic animals increases towards the equator. Furthermore, most black-skinned birds inhabit high irradiation regions, and tend to be bald and/or have white feathers. Thus, taken together, our results suggest that melanin-rich, black skin helps to protect birds against ultraviolet irradiation. More generally, our results illustrate that feathered skin colour varies taxonomically, ontogenetically and temporally, providing an additional dimension for avian colour research.
A role for actin flexibility in thin filament-mediated contractile regulation and myopathy
Authors: Viswanathan Meera C. , Schmidt William , Franz Peter , Rynkiewicz Michael J. , Newhard Christopher S. , Madan Aditi , Lehman William , Swank Douglas M. , Preller Matthias , Cammarato Anthony 
Published: May 2020

AbstractStriated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin associations. Impaired relaxation and hypercontractile properties are hallmarks of various muscle disorders. The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation lies near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here, we investigate M305L actin in vivo, in vitro, and in silico to resolve emergent pathological properties and disease mechanisms. Our data suggest the mutation reduces actin flexibility and distorts the actin-tropomyosin electrostatic energy landscape that, in muscle, result in aberrant contractile inhibition and excessive force. Thus, actin flexibility may be required to establish and maintain interfacial contacts with tropomyosin as well as facilitate its movement over distinct actin surface features and is, therefore, likely necessary for proper regulation of contraction.
Hydrodynamic slip can align thin nanoplatelets in shear flow
Authors: Kamal Catherine , Gravelle Simon , Botto Lorenzo 
Published: May 2020

AbstractThe large-scale processing of nanomaterials such as graphene and MoS2 relies on understanding the flow behaviour of nanometrically-thin platelets suspended in liquids. Here we show, by combining non-equilibrium molecular dynamics and continuum simulations, that rigid nanoplatelets can attain a stable orientation for sufficiently strong flows. Such a stable orientation is in contradiction with the rotational motion predicted by classical colloidal hydrodynamics. This surprising effect is due to hydrodynamic slip at the liquid-solid interface and occurs when the slip length is larger than the platelet thickness; a slip length of a few nanometers may be sufficient to observe alignment. The predictions we developed by examining pure and surface-modified graphene is applicable to different solvent/2D material combinations. The emergence of a fixed orientation in a direction nearly parallel to the flow implies a slip-dependent change in several macroscopic transport properties, with potential impact on applications ranging from functional inks to nanocomposites.
Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
Authors: Gouma Sigrid , Weirick Madison , Hensley Scott E. 
Published: May 2020

AbstractThe 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.