bluuebunny/crossref_metadata_2025_split huggingface dataset:
O tema mudanças climáticas em teses e dissertações brasileiras de educação ambiental
Authors: Reis Leite Danielle Aparecida , Silva Luciano Fernandes 
Published: December 2020

Este trabalho objetivou identificar aspectos do tema mudanças climáticas destacados em teses e dissertações do campo de pesquisa em Educação Ambiental (EA). Através da análise dessas informações, procurou-se explorar as compreensões apresentadas nessas pesquisas sobre o referido tema. O corpus documental, composto por dezessete dissertações de EA que exploram o tema mudanças climáticas, defendidas no período de 1987 a 2010, foi elaborado através do Banco de Teses e Dissertações da CAPES. A partir de alguns critérios, foram escolhidas cinco pesquisas desse conjunto cujos textos completos foram submetidos à análise de conteúdo. Das considerações a respeito do tema, presentes nessas pesquisas, foram elaboradas três categorias que apresentam as compreensões dos autores desses trabalhos sobre as causas das mudanças climáticas, suas consequências e as possíveis medidas capazes de mitigar seus efeitos. Ao discutir as origens do fenômeno, dois trabalhos recorrem a sua complexidade para justificar a dificuldade de eleger uma única causa, seja ela de origem natural ou antrópica e, assim, evidenciam as controvérsias científicas envolvidas nesse assunto. Três pesquisas apresentam posicionamentos sensacionalistas ao destacar as consequências das mudanças climáticas, aspecto que é problematizado por outros dois trabalhos ao enfatizarem que as incertezas relacionadas a um fenômeno complexo dificultam a apresentação de tais previsões. Por fim, é importante enfatizar os argumentos presentes em uma dissertação que, ao apresentar as medidas de mitigação para o fenômeno, trata das controvérsias econômicas e políticas e que resultam do debate acerca da adoção de tais medidas. Com isso, conclui-se que esses pesquisadores apresentam informações importantes sobre o tema, aspecto que, certamente, pode incentivar a área de pesquisa em EA a aprofundar as reflexões sobre as mudanças climáticas e a propor novos problemas de pesquisa.
Panorama das pesquisas acadêmicas brasileiras sobre o pensamento bachelardiano no ensino em matemática e ciências
Authors: Koeppe Cleise Helen Botelho , Ribeiro Marcus Eduardo , Calabro Luciana 
Published: December 2020

O presente artigo integra uma pesquisa de doutorado desenvolvida por um de seus autores e busca identificar as ideias do filósofo Gaston Bachelard presentes em teses e dissertações em Ensino publicadas no Brasil entre os anos de 2014 e 2018. Procura-se identificar a compreensão dos autores desses trabalhos a respeito das teorias de Bachelard, além de verificar a atualidade dessas ideias para o Ensino em Matemática e Ciências. Na pesquisa identificam-se as unidades federativas nas quais esses estudos foram desenvolvidos, os sujeitos de pesquisa e as áreas de ensino às quais se referem. Investiga-se, ainda, como essas ideias são empregadas pela pesquisa nessas áreas de ensino. O corpus de análise se consistiu de 16 teses e 49 dissertações recuperadas a partir do catálogo CAPES de Teses e Dissertações, considerando os filtros de pesquisa Bachelard – Ensino em Matemática e Ciências e Obstáculos epistemológicos, analisadas seguindo os preceitos da Bibliometria (HAYASHI et al., 2008) e da Análise Textual Discursiva (MORAES; GALIAZZI, 2007), caracterizando a abordagem metodológica mista, isto é, quali-quantitativa. As teses e dissertações investigadas foram desenvolvidas no território nacional, contemplando docentes e discentes de diversas áreas e níveis do Ensino. Da análise desses textos emergiram as categorias Os aspectos filosóficos no pensamento de Bachelard e Os aspectos pedagógicos no pensamento de Bachelard, com destaque para as temáticas obstáculos epistemológicos, erro, racionalismo aplicado, perfil epistemológico, filosofia/epistemologia geral e conhecimento aproximado. Constatou-se que as ideias bachelardianas permanecem atuais e aplicáveis para o processo de ensino-aprendizagem científica, bem como respaldam e aprimoram teorias de aprendizagem contemporâneas, motivos pelos quais defende-se a importância do aprofundamento dos estudos sobre as ideias desse filósofo nos cursos de formação de professores no Brasil.
Deletion of S100a8 and S100a9 Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis
Authors: Defrêne Joan , Berrazouane Sofiane , Esparza Nayeli , Pagé Nathalie , Côté Marie-France , Gobeil Stéphane , Aoudjit Fawzi , Tessier Philippe A 
Published: December 2020

Abstract
High concentrations of the damage-associated molecular patterns S100A8 and S100A9 are found in skin and serum from patients suffering from psoriasis, an IL-17–related disease. Notably, although the expression of these proteins correlates with psoriatic disease severity, the exact function of S100A8 and S100A9 in psoriasis pathogenesis remains unclear. In this study, we investigated the role of S100A8 and S100A9 in psoriasis-associated skin hyperplasia and immune responses using S100a8−/− and S100a9−/− mice in an imiquimod-induced model of psoriasis. We found that S100a8−/− and S100a9−/− psoriatic mice exhibit worsened clinical symptoms relative to wild-type mice and increased expression of S100A9 and S100A8 proteins in keratinocytes, respectively. In addition, the loss of S100A8 enhances proliferation of keratinocytes and disrupts keratinocyte differentiation. We further detected elevated production of IL-17A and -F from CD4+ T cells in the absence of S100A8 and S100A9, as well as increased infiltration of neutrophils in the skin. In addition, treatment with anti–IL-17A and -F was found to reduce psoriasis symptoms and skin hyperplasia in S100a8−/− and S100a9−/− mice. These data suggest that S100A8 and S100A9 regulate psoriasis by inhibiting production of IL-17A and -F, thereby, to our knowledge, providing new insights into their biological functions.
Suppression of Experimental Autoimmune Encephalomyelitis by ILT3.Fc
Authors: Xu Zheng , Lin Chun-Chieh , Ho Sophey , Vlad George , Suciu-Foca Nicole 
Published: December 2020

Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease of the CNS that is characterized by demyelination, axonal loss, gliosis, and inflammation. The murine model of MS is the experimental autoimmune encephalopathy (EAE) induced by immunization of mice with myelin oligodendrocyte glycoprotein (MOG)35–55. Ig-like transcript 3 (ILT3) is an inhibitory cell surface receptor expressed by tolerogenic human dendritic cells. In this study, we show that the recombinant human ILT3.Fc protein binds to murine immune cells and inhibits the release of proinflammatory cytokines that cause the neuroinflammatory process that result in paralysis. Administration of ILT3.Fc prevents the rapid evolution of the disease in C57BL/6 mice and is associated with a profound reduction of proliferation of MOG35–55–specific Th1 and Th17 cells. Inhibition of IFN-γ and IL-17A in mice treated with ILT3.Fc is associated with delayed time of onset of the disease and its evolution to a peak clinical score. Neuropathological analysis shows a reduction in inflammatory infiltrates and demyelinated areas in the brains and spinal cords of treated mice. These results indicate that inhibition of Th1 and Th17 development provides effective suppression of EAE and suggests the feasibility of a clinical approach based on the use of ILT3.Fc for treatment of MS. Furthermore, our results open the way to further studies on the effect of the human ILT3.Fc protein in murine experimental models of autoimmunity and cancer.
A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation
Authors: Kammala Ananth K , Syed Meesum , Yang Canchai , Occhiuto Christopher J , Subramanian Hariharan 
Published: December 2020

Abstract
Mast cells are tissue-resident immune cells that play pivotal roles in initiating and amplifying allergic/anaphylactic reactions in humans. Their activation occurs via multiple mechanisms, which include cross-linking of the IgE-bound, high-affinity IgE receptors (FcεRI) by allergens or Ags and the binding of anaphylatoxins such as C3a to its receptor, C3aR. We have previously demonstrated that the Na+/H+ exchanger regulatory factor 1 (NHERF1) promotes C3aR functions in human mast cells. In the current study, we show that NHERF1 regulates mast cell response following FcεRI stimulation. Specifically, intracellular Ca2+ mobilization, activation of the MAPKs (ERK1/2 and P38), and production of cytokines (IL-13 and IL-6) following exposure to IgE/Ag were significantly reduced in mast cells from NHERF1+/‒ mice. In agreement with our in vitro data, mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis were reduced in NHERF1+/‒ mice and mast cell–deficient KitW-sh/W-sh mice engrafted with NHERF1+/‒ mast cells. Mechanistically, the levels of microRNAs (miRNAs) that regulate mast cell responses, miRNA 155-3p and miRNA 155-5p, were altered in mast cells from NHERF1+/‒ mice. Moreover, NHERF1 rapidly localized to the nucleus of mast cells following FcεRI stimulation. In summary, our results suggest that the NHERF1 acts as an adapter molecule and promotes IgE/Ag-induced mast cell activation. Further elucidating the mechanisms through which NHERF1 modulates mast cell responses will lend insights into the development of new therapeutic strategies to target mast cells during anaphylaxis or other allergic diseases.
Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal Models
Authors: Mockus Taryn E , Munie Ashley , Atkinson Jeffrey R , Segal Benjamin M 
Published: December 2020

Abstract
Multiple sclerosis (MS), a neuroinflammatory disease that affects millions worldwide, is widely thought to be autoimmune in etiology. Historically, research into MS pathogenesis has focused on autoreactive CD4 T cells because of their critical role in the animal model, experimental autoimmune encephalomyelitis, and the association between MS susceptibility and single-nucleotide polymorphisms in the MHC class II region. However, recent studies have revealed prominent clonal expansions of CD8 T cells within the CNS during MS. In this paper, we review the literature on CD8 T cells in MS, with an emphasis on their potential effector and regulatory properties. We discuss the impact of disease modifying therapies, currently prescribed to reduce MS relapse rates, on CD8 T cell frequency and function. A deeper understanding of the role of CD8 T cells in MS may lead to the development of more effective and selective immunomodulatory drugs for particular subsets of patients.
Enhanced Proliferation of Ly6C+ Monocytes/Macrophages Contributes to Chronic Inflammation in Skin Wounds of Diabetic Mice
Authors: Pang Jingbo , Maienschein-Cline Mark , Koh Timothy J 
Published: December 2020

Abstract
Diabetic wounds are characterized by persistent accumulation of proinflammatory monocytes (Mo)/macrophages (MΦ) and impaired healing. However, the mechanisms underlying the persistent accumulation of Mo/MΦ remain poorly understood. In this study, we report that Ly6C+F4/80lo/− Mo/MΦ proliferate at higher rates in wounds of diabetic mice compared with nondiabetic mice, leading to greater accumulation of these cells. Unbiased single cell RNA sequencing analysis of combined nondiabetic and diabetic wound Mo/MΦ revealed a cluster, populated primarily by cells from diabetic wounds, for which genes associated with the cell cycle were enriched. In a screen of potential regulators, CCL2 levels were increased in wounds of diabetic mice, and subsequent experiments showed that local CCL2 treatment increased Ly6C+F4/80lo/− Mo/MΦ proliferation. Importantly, adoptive transfer of mixtures of CCR2−/− and CCR2+/+ Ly6Chi Mo indicated that CCL2/CCR2 signaling is required for their proliferation in the wound environment. Together, these data demonstrate a novel role for the CCL2/CCR2 signaling pathway in promoting skin Mo/MΦ proliferation, contributing to persistent accumulation of Mo/MΦ and impaired healing in diabetic mice.
Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells
Authors: Adams Nicholas M , Diaz-Salazar Carlos , Dang Celeste , Lanier Lewis L , Sun Joseph C 
Published: December 2020

Abstract
Heterogeneity among naive adaptive lymphocytes determines their individual functions and fate decisions during an immune response. NK cells are innate lymphocytes capable of generating “adaptive” responses during infectious challenges. However, the factors that govern various NK cell functions are not fully understood. In this study, we use a reporter mouse model to permanently “time stamp” NK cells and type 1 innate lymphoid cells (ILC1s) to characterize the dynamics of their homeostatic turnover. We found that the homeostatic turnover of tissue-resident ILC1s is much slower than that of circulating NK cells. NK cell homeostatic turnover is further accelerated without the transcription factor Eomes. Finally, heterogeneity in NK cell age diversifies NK cell function, with “older” NK cells exhibiting more potent IFN-γ production to activating stimuli and more robust adaptive responses during CMV infection. These results provide insight into how the functional response of an NK cell varies over its lifespan.
Para uma Filologia Política. Educação e justiça em Nietzsche
Authors: Oliveira Flávio Valentim de 
Published: December 2020

O objetivo deste artigo é investigar o itinerário reflexivo de Nietzsche sobre a educação, especialmente nas obras do chamado segundo período que são Humano, demasiado humano (1878), Aurora (1881), Além do Bem e do Mal (1886), procurando perceber ao mesmo tempo como esse itinerário filosófico explicita as próprias noções nietzschianas de justiça e de crítica da modernidade política.
FREQUENCY OF ABO, RH AND ABO-RH BLOOD GROUPS IN STUDENTS OF GOMAL MEDICAL COLLEGE, D.I.KHAN, PAKISTAN
Authors: Amin Sadiq , Ahmad Jawad , Khan Muhammad Suhail , Khan Amanullah , Khan Rashid Hassan , Umar Muhammad , Rehan Muhammad , Ullah Sifat , Ullah Barkat , Sani Muhammad , Zia Abdullah , Khan Ashraf , Kundi Asif , Ullah Rizwan 
Published: December 2020

Background: Blood group of an individual is commonly determined by ABO & Rh status. The objectives of the study were to determine the frequency of ABO, Rh and ABO-Rh blood groups in students of Gomal Medical College, D.I.Khan, Pakistan. Materials & Methods: This cross-sectional study was conducted in the Department of Community Medicine, Gomal Medical College, D.I.Khan, Pakistan from April 1 to May 23, 2019. The population being accessible was taken as sample. Sample size was 452. Our research variables (attributes) were ABO (A, B, AB, O), Rh (positive and negative) and ABO-Rh (A+, B+, AB+ O+, A-, B-, AB-, O-) respectively. All variables being nominal were described by count and percentage. The estimated parameters were given as confidence interval for proportion at 95% confidence level. The observed frequency of ABO, Rh and ABO-Rh blood groups was tested against their expected frequency using chi-square goodness of fit test. Results: Out of 452 students, the frequency of ABO blood group was; A 127 (28.12%), B 165 (36.53%), AB 57 (12.62%) & O 103 (22.73%); Rh blood group was; Rh+ 408 (90.33%) & Rh- 44 (9.67%) and ABO-Rh was; A+ 116 (25.60%), B+ 148 (32.05%), AB+ 50 (11.30%), O+ 91 (20.10%), A- 11 (2.40%), B- 17 (03.70%), AB- 7 (1.50%) & O- 12 (2.60%). The observed frequency of ABO & ABO-Rh blood groups was significantly different whereas of Rh blood group was similar to expected prevalence. Conclusion: In our population, most common blood group was B+ and the least common was AB-. The observed frequency of ABO & ABO-Rh blood groups was different while of Rh was same as expected. Awareness of blood groups in populations will help in the effective management of blood banks record in routine as well as during blood related life emergency situations.
Sistema automatizado para monitorear el uso de equipos de protección personal en la industria de la construcción
Authors: Massiris M. , Fernández J. A. , Bajo J. , Delrieux C. 
Published: December 2020

Este artı́culo presenta un novedoso sistema de visión por computador que genera indicadores automatizados de uso adecuado de equipos de protección personal (EPP) de gran importancia en la industria de la construcción, concretamente el uso de casco de seguridad y chaleco de alta visibilidad. El sistema se construye sobre una arquitectura de redes neuronales que trabaja sobre imágenes digitales. Primero se utiliza la red neuronal OpenPose para la detección de puntos antropométricos de los trabajadores visualizados, los cuales se utilizan para segmentar automáticamente regiones de interés (ROI) ubicadas en la cabeza y el tronco. Sobre estas ROI, un clasificador neuronal estima la presencia o ausencia de los dos EPP de interés. Los resultados obtenidos en vı́deos tomados en movimiento por drones o smartphones muestran que nuestro sistema es plenamente capaz de realizar una evaluación completa de indicadores de utilización de estos dos EPP sin asistencia, con el propósito principal de prevenir incidentes potencialmente peligrosos en el lugar de trabajo.
NON-HYBRID ENSEMBLE SPATIAL REGRESSION ON HUMAN DEVELOPMENT INDEX (IPM) in CENTRAL JAVA
Authors: Sazaen Evi Ardiati 
Published: December 2020

The human development index (HDI) is a measure to see an increase in regional development that has a very broad dimension, because it increases the quality of the population of an area in terms of life expectancy, education, and decent standard of living. In 2010 the Central Java HDI increased by 66.08% and increased by 4.44%, with the total HDI in 2017 of 70.52 percent. Spatial regression is the development of classical linear regression involving the region model. Spatial regression ensemble is a technique to be sent spasi spatial regression models by adding noise (additive noise). The type of spatial weighting used is Queen Contiguity. The selection of the best model using AIC and RMSE values. The purpose of this study is to provide an assessment of the distribution of HDI data in the Province of Central Java in 2017 and to do modeling using non-hybrid spatial ensemble regression regression. The results of this study are the SAR spatial method with ensemble giving results with AIC value of 143 and RMSE value of 1.3899 with a value of 90.09%. Significant variables on HDI are population density (X1), poverty (X2), school participation rates (X5), and average per capita per month for food and non-food (X7).
Comment on “Estimating the depth and evolution of intrusions at resurgent calderas: Los Humeros (Mexico)” by Urbani et al. (2020)
Authors: Norini Gianluca , Groppelli Gianluca 
Published: December 2020

Abstract. A multiple shallow-seated magmatic intrusion model has
been proposed by Urbani et al. (2020) for the resurgence of the Los Potreros
caldera floor, in the Los Humeros volcanic complex (LHVC). This model predicts (1) the occurrence of localized bulges in the otherwise undeformed caldera
floor, and (2) that the faults corresponding to different bulges exhibit
different spatial and temporal evolution. Published data and a morphological
analysis show that these two conditions are not met at Los Potreros caldera.
A geothermal well (H4), located at the youngest supposed bulge (Loma Blanca)
for which Urbani et al. (2020) calculated an intrusion depth (425±170 m), does not show any thermal and lithological evidence of such a
shallow-seated cryptodome. Finally, published stratigraphic data and
radiometric dating disprove the proposed common genesis of Holocene
resurgence faulting and viscous lavas extruded in the centre of the caldera.
Even if recent shallow intrusions do exist in the area, published data
indicate that the pressurization of the LHVC magmatic–hydrothermal system
driving resurgence faulting occurs at greater depth. Thus, we suggest that
the model and calculation proposed by Urbani et al. (2020) are unlikely to
have any relevance to the location, age and emplacement depth of magma
intrusions driving resurgence at the Los Potreros caldera.
Seismic gaps and intraplate seismicity around Rodrigues Ridge (Indian Ocean) from time domain array analysis
Authors: Singh Manvendra , Rümpker Georg 
Published: December 2020

Abstract. Rodrigues Ridge connects the Réunion hotspot track with the Central Indian Ridge (CIR) and has
been suggested to represent the surface expression of a sub-lithospheric flow channel. From global
earthquake catalogues, the seismicity in the region has been associated mainly with events related
to the fracture zones at the CIR. However, some segments of the CIR appear void of seismic
events. Here, we report on the seismicity recorded at a temporary array of 10 seismic stations
operating on Rodrigues Island from September 2014 to June 2016. The array analysis was performed
in the time domain by time shifting and stacking the complete waveforms. Event distances
were estimated based on a 1-D velocity model and the travel time differences between S and
P wave arrivals. We detected and located 63 new events that were not reported by the global
networks. Most of the events (51) are located off the CIR and can be classified as intraplate
earthquakes. Local magnitudes varied between 1.6 and 3.7. Four seismic clusters were observed that occurred to the west of the spreading
segment of the CIR. The Rodrigues Ridge appeared to be
aseismic during the period of operation. The lack of seismic activity along both Rodrigues Ridge
and the sections of the CIR to the east of Rodrigues may be explained by partially molten
upper-mantle material, possibly in relation to the proposed material flow between the Réunion
plume and the CIR.
Teaching Open Literacies
Authors: Croeser Sky 
Published: December 2020

Abstract
University teaching, particularly teaching with and about digital technologies, can play a role in developing and expanding open literacies. At the same time, we face a range of challenges as teachers. The managerial focus on measuring and quantifying teaching and learning outcomes within academia often works against the evidence on pedagogical best practice. Despite claims made about ‘digital natives’, we find that students of all ages frequently have difficulty sorting through the mass of information available online. It is not enough, as teachers, to simply provide content to students, or even to ‘engage’ students through gamified learning and other digitally supported teaching methods. To effectively support open literacies within university education we need to question institutionalized practices, including commitment to discipline canon and to a depoliticized, depersonalized approach to teaching. In order to be effective, I argue that our pedagogies must be diverse, context-dependent, and reflexive.
Covid-19: How Industrial Animal Agriculture Fuels Pandemics
Authors: Lymbery Philip 
Published: December 2020

The battle against the Coronavirus pandemic is without doubt the biggest global crisis in a lifetime. Could it be that the way we now produce so much of our food worldwide is already brewing up the next one? Whilst society has gone into battle with the virus, our invisible enemy, the truth is we’ve been locked in an almighty battle for some time now. At its heart lies factory farming. Keeping animals caged, crammed and confined – the way most farmed animals are now reared – provides the ideal breeding ground for new and more deadly strains of virus. Swine flu and highly pathogenic Avian flu being but two examples. Whilst Covid-19 is believed to be born out of the ill-treatment of animals caught up in wet markets and the illegal wildlife trade, it shows strong parallels with these other viruses of factory farmed origin. Both Swine flu and Avian Influenza – originating in pigs and chickens – have been devastating. The 2009 Swine flu pandemic went on to kill possibly half a million people worldwide. The next pandemic could well come from an incarcerated pig or chicken. From animals ‘grown’ like mere commodities and fed on the fruits of deforestation. Without ending the intensive farming conditions that promote the emergence of novel strains of viral disease, the next pandemic could well be on our plate.