bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carfilzomib induced cardiotoxicity in a multiple myeloma patient
Authors: Méndez-Toro Arnold , Díaz-Brochero Cándida , Acosta-Gutiérrez Estivalis 
Published: September 2020

AbstractProteasome inhibitors such as carfilzomib are indicated in multiple myeloma patients showing relapse and/or refractoriness of clonal activity. However, this therapy has been associated with a significant incidence of cardiotoxicity, especially in patients with known cardiovascular risk factors. Here we report a case of a 60-year-old woman with multiple myeloma, who developed severe congestive heart failure with positive myocardial injury biomarkers together with impaired LVEF and GLS, after treatment with carfilzomib. Therefore, chemotherapeutic drug was discontinued and neurohormonal blocking and diuretic therapy was started resulting in amelioration of symptoms, without changes in LVEF but with significant GLS improvement. Although high-grade cardiotoxicity is relatively rare in patients with non previous cardiac risk factors, it was a predictable side effect of carfilzomib use. Recognition of this syndrome is critical to instauration of appropriate therapy and prevention of morbimortality.
Perceived Opportunities to Craft Scale: adaptation and evidence of the construct validity of the Brazilian version
Authors: Pimenta de Devotto Rita , de Freitas Clarissa Pinto Pizarro , Wechsler Solange Muglia 
Published: September 2020

AbstractEmployees’ perceived opportunities to craft (POCs) influence actual job crafting behavior, which may have consequences for their well-being and work performance. This study aimed to validate the perceived opportunities to craft scale (POCS) in the Brazilian context. We collected data from Brazilian employees (N = 1451) in two separate samples. The factor structure, reliability, and convergent validity of the POCS were tested using confirmatory factor analysis (CFA), multigroup confirmatory factor analysis (MGCFA), and external variables. The results indicated that the POCS-Brazilian version (with seven-point and five-point Likert scale) replicated the unidimensional structure of the original instrument. POCs showed significant positive and moderate correlations with occupational self-efficacy, work engagement and job crafting, and negative associations with workaholism. Both POCS-Brazilian versions were reliable according to three types of reliability indexes and also showed discriminant and convergent validity evidence.
The burden of healthcare-associated infection in Ethiopia: a systematic review and meta-analysis
Authors: Alemu Abebaw Yeshambel , Endalamaw Aklilu , Bayih Wubet Alebachew 
Published: September 2020

Abstract
Background
Different primary studies in Ethiopia showed the burden of nosocomial infection across geographical setting and variant period. However, the national level of burden and types of healthcare-associated infections were unknown. Hence, this systematic review and meta-analysis estimated the overall nationwide burden and types of healthcare-associated infections in Ethiopia.

Methods
We searched PubMed, Science Direct, Google Scholar, African Journal Online, and Addis Ababa University repository by date April 7, 2020. To assess publication bias, Egger’s test regression analysis was applied. Weight-inverse random-effect model meta-analysis was used. Subgroup analysis was conducted based on ward type, study region, study design, sample size and diagnostic method, ward type, and study participants.

Results
A total of 18 studies with 13,821 patients participated in the overall prevalence estimation. The pooled prevalence of healthcare-associated infection was 16.96% (95% CI 14.10–19.82). Specifically, surgical site infection (39.66%), urinary tract infection (27.69%), bloodstream infection (19.9%), dual infections (SSI and UTI) (14.01%), and respiratory tract (13.51%) were the commonest types of healthcare-associated infection. In subgroup analysis, the highest overall prevalence was observed as surgical, gynecology, and obstetrics ward (22.42%).

Conclusions
The national prevalence of healthcare-associated infection remains high. The most common type of HCAI was surgical site infection, followed by urinary tract infection, bloodstream infection, SSI and UTI, and respiratory tract infection. The overall prevalence was highest in surgical, gynecology, and obstetrics ward. Hence, infection prevention and control should be a priority agenda in healthcare with due emphasis for surgical patients.
The anti-snoring bed - a pilot study
Authors: Wilhelm Elisabeth , Crivelli Francesco , Gerig Nicolas , Kohler Malcolm , Riener Robert 
Published: September 2020

Abstract
Purpose
Avoiding supine position can reduce snoring in most habitual snorers. However, devices that restrict the sleeping position cause discomfort or disrupt sleep resulting in low compliance. Therefore, mechanisms, which lift the trunk of the user without disturbing sleep, have been proposed. We present the first study, which investigates whether individual interventions provided by beds with lifting mechanisms are able to stop snoring (success rate) and whether they reduce the snoring index (number of total snores divided by total time in bed) using a repeated measures design. In addition, we investigated whether the intervention is interfering with the subjective sleep quality.

Methods
Twenty-two subjects were observed for four nights (adaptation, baseline, and two intervention nights). During intervention nights, the bed lifted the trunk of the user in closed-loop manner. Subjects were divided in three groups (non-snorer, snorer one, and snorer two). Non-snorers were lifted by the bed at random time points during the night. In group snorer one, a stepwise increase of the bed inclination was compared with going directly to a randomly selected angle. In group snorer two, the influence of a small inclination angle (10 ∘) and a big inclination angle (20 ∘) was compared.

Results
Snoring was stopped successfully in 22% (small angle) and 67% (big angle) of the interventions. This did not lead to a significant reduction in the snoring index. The subjective sleep quality was not reduced by the intervention.

Conclusion
The anti-snoring bed is able to stop individual episodes of habitual snoring without reducing the subjective sleep quality.

Trial Registration
https://clinicaltrials.gov, no. NCT04053738, registered 12 August 2019 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04053738.
Reverse genetics systems of plant negative-strand RNA viruses are difficult to be developed but powerful for virus-host interaction studies and virus-based vector applications
Authors: Zang Ying , Fang Xiao-Dong , Qiao Ji-Hui , Gao Qiang , Wang Xian-Bing 
Published: September 2020

AbstractPlant virus-induced diseases cause significant losses to agricultural crop production worldwide. Reverse genetics systems of plant viruses allow gene manipulation on viral genomes, which greatly facilitates studies of viral pathogenesis and interactions with host organisms. In addition, viral infectious cDNA clones have been modified as versatile recombinant vectors for virus-mediated protein overexpression, virus-induced gene silencing, and gene editing. Since genome RNAs of plant positive-strand RNA viruses are directly translatable, recovery of these viruses has been achieved more than three decades ago by simply expressing viral genome RNA or viral genome-derived in vitro synthesized transcripts in planta. In contrast, genomes of plant negative-strand RNA (NSR) viruses are complementary to their mRNAs and cannot be translated directly. Therefore, rescue of infectious plant NSR viruses from cDNA clones strictly requires the core replication proteins together with their genome RNAs which can assemble into nucleocapsid (NC) complexes as minimal infectious units. However, it is a major challenge to deliver multiple essential components in single cells and to assemble the NC complexes in vivo. Major breakthroughs in reverse genetics systems of plant non-segmented and segmented NSR viruses were just achieved in recent 5 years through various strategies, such as agroinfiltration, minireplicon systems, insect transmission and airbrush inoculation assays. In this review, we summarized critical steps toward developing reverse genetics systems for recovery of several plant NSR viruses in plants and insects. We also highlighted important applications of these reverse genetics of NSR viruses in viral gene function analyses, investigation of virus-insect-plant interactions, and genomic studies of insect vectors and host plants.
RETRACTED ARTICLE: Association of severity of coronary artery disease by SYNTAX score (SS) and lower extremity arterial disease by duplex ultrasound (DUS) study—an Indian perspective
Authors: Nandi Saumen , Mukherjee Anindya , Khanra Dibbendhu , Biswas Kaushik 
Published: September 2020

Abstract
Background
Coronary artery disease (CAD) and lower extremity artery disease (LEAD) often coexist. Ankle brachial index (ABI) has been shown to be an independent predictor of CAD. Studies have reported correlation of CAD and LEAD on the basis of ABI and also invasive angiography. But rigorous searching did not reveal any similar research where severity of LEAD was assessed by duplex ultrasound (DUS).
In this study, we assessed the association of severity and localisation of LEAD by DUS with SYNTAX score (SS).

Results
A total of 637 subjects above 45 years of age with coronary angiographic confirmation of CAD were studied in this single centre cross-sectional, descriptive and analytical research. High SS was significantly more common in subjects with LEAD (p = 0.04). In the femoro-popliteal segment, total occlusion of arteries was found in significantly more proportion of subjects with high SS. A progressive increase in mean SS was noted across the grades of arterial disease in the femoro-popliteal segment (p = 0.007). 85.2% of the LEAD was in the femoro-popliteal segment, while below-knee arterial disease was present in 98.5% of subjects with LEAD. Hypertension, smoking, history of CVE and presentation with ACS independently increased the risk of LEAD.

Conclusion
High prevalence of asymptomatic LEAD and association of high SS with LEAD as a whole as well as femoro-popliteal involvement suggests the need for a point of care DUS study (POCUS) since treatment varies with location and extent of disease which cannot be fathomed by ABI alone. Being the largest study on association of CAD and LEAD from Indian subcontinent till date and also the first study to use non-invasive tool as DUS for LEAD assessment while studying its association with CAD makes this a landmark experience.
Early discharge (within 24–72 h) in low-risk AMI patients treated with PCI: feasibility and safety—Hajj study
Authors: Khaled Sheeren , Jaha Najeeb , Shalaby Ghada , Niazi Azmat Khadija , Alhazmi Faisal , Alqasimi Hadeel , Ruzaizah Rahaf Abu , Haddad Mryam , Alsabri Mroj , Kufiah Heba 
Published: September 2020

Abstract
Background
Shortening of the hospital stay in patients admitted with the diagnosis of acute myocardial infarction (AMI) has been observed within the last decades. Our center is the only cardiac center in the region providing tertiary care facility and hence receives all AMI patients deemed suitable for invasive assessment and management and this leads to huge required demand. Our aim is to assess feasibility and safety of the early discharge of selected proportion of AMI patients.

Result
Out of 557 of patients presented with AMI and treated with percutaneous coronary intervention (PCI), 310 (56%) were discharged early. Men patients and pilgrims were more prevalent among the early discharge group. Early discharged patients had significantly less comorbidities compared to the other group of patients. Moreover, they presented mainly with ST-elevation myocardial infarction (P = 0.04) and treated more with primary percutaneous coronary intervention (PPCI) (P = 0.04). They had favorable coronary anatomy (P = 0.01 and 0.02 for left main and multi-vessel coronary artery disease, respectively), better hospital course, and higher left ventricular ejection fraction compared to non-early discharged patients (P = 0.006 and < 0.001 for pulmonary edema and left ventricular ejection fraction post myocardial infarction). Follow-up of those early discharged patients were promising as majority of them were asymptomatic (95%) and did well post-discharge.

Conclusion
Our study demonstrated data that support safety of early discharge in a carefully selected group of AMI patients. Early but safe discharge may have a huge impact on increasing bed availability, reducing hospital costs, and improving patient’s satisfaction.
Prevalence of maternal antenatal anxiety and its association with demographic and socioeconomic factors: A multicentre study in Italy
Authors: Cena L. , Mirabella F. , Palumbo G. , Gigantesco A. , Trainini A. , Stefana A. 
Published: September 2020

Abstract

Background.
Maternal antenatal anxiety is very common, and despite its short- and long-term effects on both mothers and fetus outcomes, it has received less attention than it deserves in scientific research and clinical practice. Therefore, we aimed to estimate the prevalence of state anxiety in the antenatal period, and to analyze its association with demographic and socioeconomic factors.

Methods.
A total of 1142 pregnant women from nine Italian healthcare centers were assessed through the state scale of the State–Trait Anxiety Inventory and a clinical interview. Demographic and socioeconomic factors were also measured.

Results.
The prevalence of anxiety was 24.3% among pregnant women. There was a significantly higher risk of anxiety in pregnant women with low level of education (p < 0.01), who are jobless (p < 0.01), and who have economic problems (p < 0.01). Furthermore, pregnant women experience higher level of anxiety when they have not planned the pregnancy (p < 0.01), have a history of abortion (p < 0.05), and have children living at the time of the current pregnancy (p < 0.05).

Conclusion.
There exists a significant association between maternal antenatal anxiety and economic conditions. Early evaluation of socioeconomic status of pregnant women and their families in order to identify disadvantaged situations might reduce the prevalence of antenatal anxiety and its direct and indirect costs.
The Common Agricultural Policy under the pressure of the new Financial Framework (2021-2027): Nationalization and adaptation
Authors: Δούκας Γιάννης Ε. 
Published: September 2020

The current context in which agriculture is operating is characterized by decreasing agricultural prices due to global macroeconomic conditions and geopolitical tensions - like migration. Furthermore, the emphasis of trade negotiations has shifted from multilateral to bilateral agreements, forcing the EU to lower even more its protectionist trade barriers. Additionally, the EU has signed up to new international commitments, concerning actions to deal with the climate change and sustainable development issues. Lastly, the forthcoming Brexit exerts strong fi nancial pressure on the ΕU budget for agriculture, which will be signifi cantly lower than in the current period. This article highlights the challenges that the new Common Agricultural Policy is called upon to administer, presents and attempts to evaluate the Commission’s proposals for the period 2021-27.
Comparison of major bleeding in patients with acute coronary syndrome that underwent coronary artery bypass grafting treated with clopidogrel or ticagrelor: a systematic review and meta-analysis
Authors: Rohman Mohammad Saifur , Purnamasari Yeni , Ilmawan Muhammad , Mahdi Bagus Aulia , Tamara Fredo , Mahendra Aditya Indra , Mazen Mazen , Heriansyah Teuku , Yamin Muhammad , Pikir Budi Susetio , Fajar Jonny Karunia 
Published: September 2020

Background: There is controversy among physicians regarding the use of dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients treated with coronary artery bypass grafting (CABG). Moreover, the evidence of previous studies about this topic remained inconclusive. This study aimed to perform a meta-analysis concerning the relation between the risk of major bleeding and the use of different DAPT (clopidogrel or ticagrelor) in ACS patients treated with CABG. Methods: A meta-analysis was conducted during March to October 2019. Searches were carried out in Pubmed, Embase, Cochrane, and Web of Science. The predictor covariate in our present study was DAPT (clopidogrel or ticagrelor), and the outcome measure was the risk of major bleeding. Sub-group analysis was also performed, where data were classified into pre- and post-CABG. Furthermore, to determine the correlation and effect estimation, data were analyzed using fixed or random effect model. Results: A total of 13 studies consisting 34,015 patients treated with clopidogrel and 32,661 patients treated with ticagrelor was included in our study. Our pooled calculation revealed that the incidence of major bleeding was not different significantly between clopidogrel and ticagrelor. In pre- and post-CABG sub-groups, our results also found no significant difference in major bleeding incidence between clopidogrel and ticagrelor groups. Conclusions: Our meta-analysis clarifies that clopidogrel, compared to ticagrelor, or vice versa, is not associated with the risk of major bleeding in ACS patients treated with CABG.
Abortion knowledge and experiences among young women and men in Accra, Ghana
Authors: Reiger Sarah T. , Dako-Gyeke Phyllis , Ngo Thoai D. , Eva Gillian , Gobah Leonard , Blanchard Kelly , Chandrasekaran Sruthi , Grindlay Kate 
Published: September 2020

Background: Despite the presence of legal abortion services in Ghana, unsafe abortion remains common, particularly among young women. Little is understood about what young people know about safe and legal abortion, and if and how they are utilizing it. Methods: To characterize abortion use and address gaps in safe access, from September-December 2013, we conducted a cross-sectional survey with 100 men and 250 women aged 18-24 in Accra, Ghana. Participants were asked about abortion experiences, including prior services, providers, methods, satisfaction, perceived support, and knowledge of laws. Descriptive statistics, Fisher’s exact tests, and chi-square tests were performed. Results: Among surveyed youth, most (87% of women, 64% of men) thought abortion was illegal or did not know the law. In total, 30% of women and 14% of men ever had an abortion and partner who had an abortion, respectively. Among women’s most recent abortions, medication abortion (61%), surgical methods (26%), and unsafe methods categorized “least safe” (14%) were the initial or only methods used. Most women who accessed medication abortion initially or as their only method saw a pharmacist (40%) or no one (33%). Nearly one-quarter of women (n=16, 24%) who initially took tablets used more than one method. Conclusions: Despite experiences with abortion, most young people in this study were unaware of its legality and unsafe abortions occurred. More needs to be done to ensure young people understand the law and have access to safe methods, and that pharmacists are trained to provide appropriate doses and formulations of medication abortion.
Genetic variability of Indonesian landraces of Vigna subterranea: Morphological characteristics and molecular analysis using SSR markers
Authors: ALHAMDI MUHAMMAD FAUZAN FARID , Setiawan Asep , Ilyas Satriyas , Ho Wai Kuan 
Published: September 2020

Abstract. Alhamdi MFF, Setiawan A, Ilyas S, Ho WK. 2020. Genetic variability of Indonesian landraces of Vigna subterranea: The morphological characteristics and molecular analysis using SSR markers. Biodiversitas 21: 3929-3937. Bambara groundnut (Vigna subterranea (L.) Verdc.) is a potential grain, which can be considered as an alternative source of protein and carbohydrate. Due to unavailability of commercial bambara groundut cultivar in Indonesia, the characterization of bambara groundnut landraces is an important step before developing cultivar with traits of interest. The objective of the research was to access genetic variability of Indonesian landraces of bambara groundnut with different seed coat colors based on morphological and molecular markers. The experiment was arranged as split-plot in a complete randomized block design with the main plot was cultivation methods and the sub plot was landraces. There were differences in leaf shape and pod shape among the landraces. There were two main clusters of Indonesian landraces of bambara groundnut with 88.28% similarity. The first cluster was Cream, Brown Sumedang, Black Sumedang and Black Tasikmalaya, and the second cluster was Black Sukabumi, Brown Gresik, Black Madura, and Black Gresik. The result based on SSR marker with capillary electrophoresis indicated Black Gresik and Black Madura landraces were different from other Indonesian landraces. Cream Sumedang or Brown Sumedang from the first cluster and Black Gresik or Brown Gresik from the second cluster have the farthest distances for developing improved variety of bambara groundnut.
A hybrid approach of remote sensing for mapping vegetation biodiversity in a tropical rainforest
Authors: Wardhana Wahyu , SORAYA EMMA , SOEPRIJADI DJOKO , LARASATI BEKTI , HUTOMO YAASIIN HENDRAWAN TRI , Wirabuana Pandu , WIDYATMANTI WIRASTUTI , UMARHADI DEHA AGUS , IDRIS FAHMI 
Published: September 2020

Abstract. Wardhana W, Widyatmanti W, Soraya E, Soeprijadi D, Larasati B, Umarhadi DA, Hutomo YHT, Idris F, Wirabuana PYAP. 2020. A hybrid approach of remote sensing for mapping vegetation biodiversity in a tropical rainforest. Biodiversitas 21: 3946-3953. Vegetation biodiversity is one of the most important indicators to evaluate the sustainability of tropical rainforest. It is commonly described by three essential variables, i.e. richness, heterogeneity, and evenness. That information is frequently collected from periodic forest inventory using terrestrial method. However, this effort needs a long-time consuming, high cost, and almost impossible to implement in the area of tropical rainforest with hard accessibility. This study investigates the potential of remote sensing as an alternative method for mapping vegetation biodiversity in a tropical rainforest. A hybrid approach of remote sensing using medium and high-resolution images was developed to recognize the attributes of vegetation biodiversity by considering three parameters derived from remote sensing data, including canopy density (C), crown diameter (D), and tree density (N). The use of a medium resolution image aimed to categorize vegetation density using Modified Soil-Adjusted Value Index (MSAVI) while a high-resolution image was utilized to acquire a more detailed spectrum for determining C, D, and N in every class of vegetation density. The relationship between C, D, N, and richness, heterogeneity, evenness was explained using hierarchical cluster analysis. Our study discovered the attributes of vegetation biodiversity in a tropical rainforest could be potentially recognized by combining C, D, and N as predictor variables.