bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Docking, Antioxidant, Anticancer and Antileishmanial Effects of Newly Synthesized Quinoline Derivatives
Authors: Malghani Zoonish , Khan Arif-Ullah , Faheem Muhammad , Danish Muhammad Z. , Nadeem Humaira , Ansari Sameen F. , Maqbool Madeeha 
Published: May 2020

Background:
Due to the pressing need and adverse effects associated with the available anti-cancer
agents, an attempt was made to develop the new anti-cancer agents with better activity and lesser adverse
effects.

Objective:
Synthetic approaches based on chemical modification of quinoline derivatives have been undertaken
with the aim of improving anti-cancer agents’ safety profile.

Methods:
In the present study, quinoline derivatives 6-hydroxy-2-(4-methoxyphenyl) quinoline-4-carboxylic
acid (M1) and 2-(4-chlorophenyl)-6-hydroxyquinoline-4-carboxylic acid (M3) were synthesized by the reaction
of aldehyde and pyruvic acid. The complete reaction was indicated by thin-layer chromatography. Newly synthesized
M1and M3were tested for in silico and in vitro studies.

Results:
M1 and M3 were docked against selected targets. Both the test compounds showed good affinity against
all targets except the p300\CBP-associated factor target as there was no H-bond formed by M1. IC50 values of
M1 and M3 against 1, 1-diphenyl-picrylhydrazyl free radical scavenging activity were 562 and 136.56ng/mL,
respectively. In brine shrimp lethality assay, M1 and M3 showed IC50 value of 81.98 and 139.2ng/mL, respectively.
IC50 values recorded for M1 and M3 in tumor inhibition activity were 129 and 219μg/mL, respectively.
M1 and M3 exhibited concentration-dependent anti-cancer effects against human cell lines of hepatocellular
carcinoma (HepG2) and colon cancer (HCT-116). Against HepG2 cells, M1 and M3 exhibited IC50 of 88.6 and
43.62μg/mL, respectively. M1 and M3 utilized against HCT-116 cell lines possessed IC50 values of 62.5 and
15.3μg/mL. M1 and M3 also showed an anti-leishmanial effect with IC50 values of 336.64 and 530.142μg/mL,
respectively.

Conclusion:
From the results of pharmacological studies, we conclude that the newly synthesized compound
showed enhanced anti-oxidant, anti-cancer and anti-leishmanial profile with good yield.
Sero-epidemiology of Hydatidosis Among General Population of Jolfa County, Northwestern Iran Using IHA, ELISA and Western Blot (2017-2018)
Authors: Sakhaei Ghorban , Khademvatan Shahram , Hazrati Tappeh Khosrow , Masudi Sima , Feizollahzadeh Sadegh , Aminpour Arash , Asadi Negar 
Published: May 2020

Background:
Human hydatidosis is mostly a latent and neglected disease with known
endemicity in Iran.

Aims :
Due to the importance of this infection in the country and its latent nature, we aimed to
evaluate the serological status of hydatid cyst in northwestern Iran.

Objectives:
Herein, we evaluated the serological status of hydatid cyst in urban and rural
inhabitants of Jolfa county, northwestern Iran during 2017-2018.

Methods:
In total, 1296 blood samples were obtained from human individuals and the presence of
anti-E. granulosus antibodies was investigated using IHA, ELISA and WB.

Results:
Based on results, 25 IHA positive person were detected in the examined population, however
ELISA test showed 14 of 25 IHA positive patients as negative. Also, 269 IHA negative fellows
were shown as negative by ELISA. WB analysis of sera from 25 IHA positive subjects revealed
consistent results with the ELISA test, and the most reactive SHCF Ag was a 37 KDa protein.
The age-standardized seroprevalence of hydatidosis among Jolfa's general population was
1.12% with 95%CI: 1.02-1.20. Moreover, there existed a significant association between keeping/-
contact with dogs (P = 0.022) as well as vegetable consumption (P < 0.001) with ELISA positive
test results.

Conclusion:
Along such serological evidence in this region, we highly suggest physical
examination and applying imaging techniques for suspected cases in the area for better
understanding of CE.
Potent Antihyperglycemic Effect of an Endemic Plant from Morocco (Matthiola Maroccana Coss.) on Normal and Streptozotocin-Induced Diabetic Rats
Authors: Amssayef Ayoub , Lahrach Nadia , Eddouks Mohamed 
Published: May 2020

Background:
Matthiola maroccana (Coss.) belongs to the Brassicaceae family and it is an
endemic plant from Morocco.

Objective:
The objective of the study was to evaluate the effect of aqueous extract of Matthiola maroccana
(Coss.) on blood glucose levels in normal and diabetic rats.

Methods:
The effect of single dose (6 hours) and daily oral administration for seven days of the Aerial
Part Aqueous Extract (A.P.A.E) of Matthiola maroccana (Coss.) (M. maroccana) at a dose of 20
mg/kg body weight on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rats
was observed. Furthermore, body weight, oral glucose tolerance test, liver histopathological examination,
phytochemical screening, and in vitro antioxidant activity of A.P.A.E were evaluated in this
study.

Results:
The results showed that M. maroccana A.P.A.E exerts potent hypoglycemic and antihyperglycemic
effects on normal and STZ-induced diabetic rats (p<0.0001). Also, it was able to restore body
weight in diabetic rats (p<0.05). Furthermore, the aqueous extract has been shown to regenerate hepatic
tissues in diabetic rats. Besides, A.P.A.E revealed the presence of several phytochemical constituents
(polyphenols, flavonoids, tannins, saponins, alkaloids, sterols and terpenoids), and possessed
antioxidant activity.

Conclusion:
In conclusion, our findings showed that A.P.A.E of M. maroccana (A.P.A.E MM) possesses
significant antihyperglycemic and hypoglycemic activities.
Awareness and Practices of Dental Students and Dentists Regarding Infection Control in Prosthodontic Clinics
Authors: Halawani Ragheb , Aboalshamat Khalid , Alwsaidi Ruba , Sharqawi Sultana , Alhazmi Rawan , Abualsaud Zahra , Alattallah Amal , Alamri Maha 
Published: May 2020

Background:Patient safety is a priority for achieving higher quality health care standards and human error> reduction.Objective:The aim of this study was to evaluate the level of appropriate infection control practices in a prosthodontic clinic in Jeddah, Saudi Arabia.Methods:This cross-sectional study included 460 dental students and dentists recruited from five centers. Data were collected by self-administered questionnaires> composed of 25 questions. The questionnaires> assessed infection control practices in prosthodontic clinics, including wearable barriers, disinfection measures among patients, disinfection of laboratory submissions, and proper infection control. Other questions assessed sources of knowledge, self-evaluation of knowledge, implementation, and satisfaction with knowledge application.Results:Total correct answers for proper practice (16 questions) had a mean of 12.5 with a standard deviation of 2.8. The most commonly practiced procedure was wearing a mask (99.8%) and the least was sterilizing the facebow before its use by the patient (53.7%). Participants from governmental colleges (m = 13.67, SD = 2.17) had significantly higher scores than participants from private colleges (m = 12.35, SD = 2.9),p<0.001. Only 2.8% had never attended a lecture, and only 13.8% had never had hands-on training for infection control. Despite 49.1% evaluating themselves as having very poor to poor knowledge, 90.7% had fair to very good valuation of their infection control implementations, and 87.6% were satisfied with their knowledge and performance levels.Conclusion:Dental students and dentists have high levels of adequate infection control practices in the prosthodontic clinic despite the moderate level of their satisfaction with their knowledge.
Oncogenomics and CYP450 Implications in Personalized Cancer Therapy
Authors: Udayaraja G.K. , Emerson I. Arnold 
Published: May 2020

Background:
The Human Genome Project has unleashed the power of genomics
in clinical practice as a choice of individualized therapy, particularly in cancer
treatment. Pharmacogenomics is an interdisciplinary field of genomics that deals with
drug response, based on individual genetic makeup.

Objective:
The main genetic events associated with carcinogenesis activate oncogenes or
inactivate tumor-suppressor genes. Therefore, drugs should be specific to inactivate or
regulate these mutant genes and their protein products for effective cancer treatment. In
this review, we summarize how polymedication decisions in cancer treatments based on
the evaluation of cytochrome P450 (CYP450) polymorphisms are applied for pharmacogenetic
assessment of anticancer therapy outcomes.

Results:
However, multiple genetic events linked, inactivating a single mutant gene product,
may be insufficient to inhibit tumor progress. Thus, genomics and pharmacogenetics
directly influence a patient’s response and aid in guiding clinicians to select the safest and
most effective combination of medications for a cancer patient from the initial prescription.

Conclusion:
This review outlines the roles of oncogenes, the importance of cytochrome
P450 (CYP450) in cancer susceptibility, and its impact on drug metabolism, proposing
combined approaches to achieve precision therapy.
In-situ Intestinal Absorption and Pharmacokinetic Investigations of Carvedilol Loaded Supersaturated Self-emulsifying Drug System
Authors: Krishna Vamshi M. , Kumar Vijaya B. , Dudhipala Narendar 
Published: May 2020

Background:
Carvedilol (CD), a non-selective beta-blocker, is indicated for the management
of mild to moderate congestive heart failure. After oral administration, CD is rapidly absorbed
with an absolute bioavailability of 18-25% because of low solubility and extensive first-pass metabolism.

Objective:
The present investigation focused on enhanced oral delivery of CD using supersaturated
self-emulsifying drug delivery (SEDDS) system.

Methods:
Optimized SEDDS consisted of a blend of Oleic acid and Labrafil-M2125 as an oil-phase,
Cremophor-RH40, polyethylene glycol-400 and HPMC-E5 as a surfactant, co-surfactant and supersaturation
promoter respectively. Formulations were characterized for physical characteristics, invitro
release in simulated and biorelevant dissolution media, intestinal permeability and bioavailability
studies in Wistar rats. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis,
scanning electron microscopy (SEM) studies were used to confirm the crystalline nature and
shape of the optimized formulation.

Results:
DSC and XRD, SEM studies showed that the drug was in amorphous form, and droplets
were spherical in shape. Dissolution studies clearly showed distinct CD release in compendial and
biorelevant dissolution media. The results from permeability and in-vivo studies depicted 2.2-folds
and 3.2-folds increase in permeability and bioavailability, respectively from supersaturated SEDDS
in comparison with control.

Conclusions:
The results conclusively confirmed that the SEDDS formulation could be considered as
a new alternative delivery vehicle for the oral supply of CD.

Lay Summary:
Carvedilol (CD) is a non-selective antihypertensive drug with poor oral bioavailability.
Previously, various lipid delivery systems were reported with enhanced oral delivery. We developed
suprsaturable SEDDS formulation with immediate onset of action. SEDDS formulation was developed
and optimized as per the established protocols. The optimized SEDDS formulation was stable
over three months and converted to solid and supersaturated SEDDS. The results from permeability
and in-vivo studies demonstrated an enhancement in permeability and bioavailability from supersaturated
SEDDS in comparison with control. The results conclusively confirmed that the SEDDS formulation
could be considered as a new alternative delivery vehicle for the oral administration of CD.
Numerical DEM Analysis on Coal Loading Process of Shearer Spiral Drum
Authors: Tian Zhen , Jing Shuangxi , Gao Shan , Zhao Lijuan 
Published: May 2020

Background:
In order to study the loading process of shearer spiral drum, the theoretical
model of loading process of spiral drum was established based on the kinematic characteristics of coal
block in the envelope region of spiral drum.

Objective:
A spiral drum was designed for MG400/951-WD shearer, and this spiral drum was taken as
the research object, the influence of spiral angle of the blade and rotation speed of the spiral drum on
the theoretical coal capacity was analyzed.

Methods:
The intrinsic parameters of coal were calibrated according to the physical and mechanical
properties of coal samples in Ordos Wenyu coal mine, a discrete element model of the coupling of the
spiral drum and the coal wall was constructed.

Results:
The velocity and mass distribution of coal particles in the loading process were obtained by
numerical simulation. The simulation results show that the loading rate of spiral drum was 65.6%.
Through industrial test and theoretical calculation, the coal loading rate of spiral drum under the same
conditions was 63% and 68.4%, and the maximum relative error between the results and theoretical
calculation was 7.89%.

Conclusion:
The error between the coal loading rate obtained by the simulation, theoretical calculation
and the test was small. It shows that the simulation results can accurately reflect the coal charging process
of the spiral drum. In this article, various patents have discussed.
An Efficient Shot Boundary Detection Using Data-cube Searching Technique
Authors: Kavitha J. , Rani P. Arockia Jansi , Fathimal P. Mohamed , Paul Asha 
Published: May 2020

Background::
In the internet era, there is a prime need to access and manage the huge
volume of multimedia data in an effective manner. Shot is a sequence of frames captured by a single
camera in an uninterrupted space and time. Shot detection is suitable for various applications such
that video browsing, video indexing, content based video retrieval and video summarization.

Objective::
To detect the shot transitions in the video within a short duration. It compares the visual
features of frames like correlation, histogram and texture features only in the candidate region
frames instead of comparing the full frames in the video file.

Methods:
This paper analyses candidate frames by searching the values of frame features which
matches with the abrupt detector followed by the correct cut transition frame with in the datacube
recursively until it detects the correct transition frame. If they are matched with the gradual detector,
then it will give the gradual transition ranges, otherwise the algorithm will compare the frames within
the next datacube to detect shot transition.

Results::
The total average detection rates of all transitions computed in the proposed Data-cube
Search Based Shot Boundary Detection technique are 92.06 for precision, 96.92 for recall and 93.94
for f1 measure and the maximum accurate detection rate.

Conclusion::
Proposed method for shot transitions uses correlation value for searching procedure
with less computation time than the existing methods which compares every single frame and uses
multi features such as color, edge, motion and texture features in wavelet domain.
Green Synthesis of Some Novel Imidazole Schiff base Derivatives Under Microwave Irradiation / Reflux Conditions and Evaluations of the Antibacterial Activity
Authors: Eftekhari Samaneh , Foroughifar Naser , Hallajian Sara , Khajeh-Amiri Alireza 
Published: May 2020

Background:
Schiff bases are excellent compounds. They were synthesized by condensation
of active carbonyl and amines. They were widely used as a substrate in the preparation of industrial
compounds as well as pharmaceutical purposes. They exhibit a wide range of biological activities.
In this study, based on the importance of Schiff bases, a sustainable synthetic method was developed
employing reflux and microwave irradiation.

Objective:
Develop a new synthetic method for imidazole Schiff base derivatives synthesis employing reflux, microwave
irradiation, and ethanol as a green solvent.

Methods:
Synthesis of imidazole Schiff base derivatives was carried out under reflux and microwave
irradiation conditions. Antibacterial activity of imidazole derivatives and standard drugs was examined
against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gramnegative
bacteria (Proteus mirabilis, Escherichia coli).

Results:
Schiff bases were synthesized in the presence of microwave irradiation and ethanol in high
yields 90-98% for 2-4 min. The antibacterial effects of Schiff bases were evaluated against both
strains of Gram-positive and Gram-negative.

Conclusion:
In this paper, a novel series of imidazole Schiff base derivatives were synthesized using
reflux, microwave irradiation, and ethanol. Antibacterial effects were investigated. The excellent advantages
of microwave irradiation in the synthesis of imidazole derivatives include reduction of reaction
time from an hour to a minute, high product yield. In this study, the measurement of antibacterial
activity was also important. Imidazole derivatives with Cl, OH, and CH3 groups showed antibacterial
effects.
Team Monitoring, Does it Matter for Team Performance? Moderating role of Team Monitoring on Team Psychological Safety and Team Learning
Authors: Budianto Tarman , Susanto Ely , Sitalaksmi Sari , Kismono Gugup 
Published: May 2020

Introduction: The use of work teams is a strategy that allows organizations to move faster and more proactively. Team performance is an interesting issue that needs to be studied more extensively. Background Problems: Team psychological safety and team learning have a positive effect on team performance. But in some of the literature, psychological safety has also been shown to have a negative impact on teams when team monitoring is low. This research was conducted to investigate the moderation role of team monitoring and the influence of team learning and team psychological safety on team performance. Novelty: This research contributes new insights related with team monitoring and its interaction to team learning and team psychological safety on team performance. Team psychological safety has been proven to be able to directly influence team performance indirectly through team learning, but we tested the two separately. Research Methods: This study involved 215 respondents who joined 38 teams. The collected data were analyzed using a regression analysis and bootstrap techniques. Findings: Team monitoring has been shown to have a moderate role in influencing team learning on team performance, but it has not been proven to influence team psychological safety on team performance. The learning and psychological safety of each team proved to have a direct effect on team performance. Conclusion: This paper can guide managers since, at a certain level team monitoring can improve team performance, but too much team monitoring actually has no effect on team performance. Managers need to consider team monitoring policies carefully, to optimizing team performance by managing team learning and building team psychological safety.
Co-existing with COVID-19. Design for Resistance
Authors: Capua Alberto De , Errante Lidia , Palco Valentina 
Published: May 2020

The paper investigates urban and domestic living and how these have been modified by the new needs, concerns and fears connected to the most recent global pandemic. The contribution highlights how urban and domestic dimensions are key elements of our existence and resistance. The topic is articulated in a twofold dimension: - the urban scale of the city, which is continuing to function even during the emergency, allowing us to believe that the tools in our hands are capable of being used in a more flexible way, both from a political-based and a design-based perspective;- the domestic sphere, whose connotations make the house versatile and flexible in the context of the progress and technological advancement that is now happening in the community and for this reason the space must meet the requirements of adaptability to operate perfectly even as a workplace. Eventually, the contribution defines the requirements for a resistant living, and the tools that will enable us to design resistant urban and domestic space.
EXPERIÊNCIAS HETEROBIOGRÁFICAS NA EDUCAÇÃO DE JOVENS E ADULTOS
Authors: De Andrade Francisco Ari , Paixão Erinelda da Costa , Ximenes Cristiane da Silva 
Published: May 2020

O presente trabalho apresenta heterobiografia de alunos da Educação de Jovens e Adultos - EJA, no atual contexto da educação brasileira. Heterobiografia é a ação formativa na promoção da ressignificação das experiências de vida dos sujeitos escolares, na medida em que se percebem no mundo na relação com o outro, tomando consciência de seu papel histórico. O corpus dessa pesquisa foi desenvolvido em duas etapas. Na primeira etapa, foi feito um levantamento bibliográfico sobre a discussão epistemológica da EJA. Na segunda, foi realizada uma atividade junto aos alunos em sala de aula da EJA, na qual cada um foi capaz de narrar o sentido da sua existência como sujeito social. Por amostragem, ao grupo de treze alunos, com idade média em torno de 35 anos, foi apresentado alguns contos biográficos. Em seguida, eles foram orientados a escrever suas histórias de vida. A partir dessa dinâmica em sala de aula, as narrativas geradas revelaram que a heterobiografia se constitui num elemento de construção de sentido, na qual os estudantes se percebem como sujeitos ao apreenderem as significações de suas experiências de vida.
The impact of Nodes Distance on Wireless Energy Transfer System
Authors: Risma Pola , Dewi Tresna , Oktarina Yurni 
Published: May 2020

Wireless energy transfer (WET) reemerges as the method for transmitting electric power without the necessity to deal with cable losses and an aesthetically pleasing environment. The problem with WET is how to maintain magnetic induction as the distance gets further. This paper investigates the impact of nodes distance on the WET system. The experimental results show that the most effective distance among transmitter, nodes, and receiver are 4 cm. The measurement is taken with and without load. The without load application give that for node 1; the results are 6 V, 110 mA, and 2.85 mT for voltage, current, and magnetic flux, respectively. At the application of 2 nodes, the voltage is 6.8 V, the current is 0.124 mA, and the magnetic flux is 3.83 mT, and at three nodes installation, it is 7 V, 134 mA, and 3.83 mT. During the application of 3-Watt and 5-Watt lamp, at 4 cm distance, the power received is 1.66 W and 3.66 W at 3-Watt and 5-Watt lamp for one node, 1.84 W, and 3.84 for two nodes, and 1.93 W and 3.93 for three nodes. The experimental results show that the transmitted signal can be prolonged by installing nodes. Even though this study shows that 4 cm is the most effective, it is possible to increase up to 20 cm to power a 3-Watt lamp and 5-Watt lamp.