bluuebunny/crossref_metadata_2025_split huggingface dataset:
M4205 (IDRX-42) is a highly selective and potent inhibitor of relevant oncogenic driver and resistance variants of KIT in cancer
Authors: Esdar Christina , LInde Nina , Blum Andreas , Schieferstein Hanno , Drechsler Christine , Sherbetjian Eva , Petersson Carl , Ross Edith , Leuthner Birgitta , Grädler Ulrich , Dorsch Dieter , Blaukat Andree 
Published: February 2025

Abstract
Primary activating mutations in KIT (exons 9/11) are key driver alterations in about 80% of gastrointestinal stromal tumors (GIST). Imatinib, a small molecule tyrosine kinase inhibitor, is used successfully as first-line therapy for unresectable metastatic or recurrent GIST patients, but secondary resistance mutations in the KIT kinase domains frequently occur. Currently approved later-line therapies target these mutations incompletely with limited clinical benefit. M4205, a kinome-selective KIT inhibitor, was designed to address this high unmet medical need by inhibiting all relevant KIT driver and resistance mutations. Compared to imatinib, M4205 shows stronger antitumor activity in preclinical GIST models driven by oncogenic KIT driver mutations. M4205 demonstrates clinically relevant efficacy in a range of preclinical GIST models expressing different secondary KIT resistance mutations. The kinase selectivity profile of M4205 is superior to registered standard of care and investigational agents. M4205, now IDRX-42, is currently being investigated in a Phase 1 first-in-human study in participants with GIST.
An Extended Refutation of Doctrinal Correlates in John 8–9
Authors: Terian Abraham 
Published: February 2025

Abstract
The doctrinal continuum between ancestral merits and rewards and punishments is well established in Second Temple Judaism and is discernible in John 8–9. Following Philo of Alexandria’s questioning of these doctrinal correlates, the Johannine chapters are subjected to a theological-rhetorical analysis focused on the transitional passage (9:1–5). The passage is here seen not as an introduction to a new theme but as corollary to the preceding chapter(s), having a duo-directional significance, linking a two-part refutation of invariably related doctrines: ancestral merits and rewards and punishments. The rejection or refutation of the latter affirms the rejection or refutation of the former, and vice versa. The Johannine chapters in question have a thematic and dialectical connection; they constitute a substantial part of the broader, interrelated polemic of the Fourth Gospel.
Jesus’s Solidarity with Human Mortality and Perfection of Sonship in the Epistle to the Hebrews
Authors: Lee Jihye 
Published: February 2025

Abstract
In relation to the discussion on the concept of perfection in Hebrews, the author’s emphasis on Jesus’s solidarity with human mortality has been considered as simple reference to the precondition of his Christological role and his sympathetic character, which shares human weaknesses. However, the substantial connection between the discussions on sonship in Heb 12 and on the Son in Heb 1–2 suggests a fresh reading of the text’s emphasis on Jesus’s mortality along with his role as ἀρχηγός of other sons. The author of Hebrews presents the notion that human mortality is a divinely designed opportunity for the sons of God to acquire the discipline necessary to be prepared to become the heirs of the eternal inheritance. The one who totally entrusts his own life to the Father is the genuinely obedient son, and this true obedience is cultivated when the sons choose obedience on the occasion of the test, i.e., “fear of death,” which is unaffectedly derived from the status of mortality.
Body condition index of Bombina variegata variegata (Linneus,1758) in different habitats
Authors: Trenti Matteo , Sacchi Roberto , Romano Antonio , Endrizzi Sonia 
Published: February 2025

Abstract
Understanding how threatened amphibians respond to alternative environments, such as human made site and human exploited landscape is a crucial point of view for future conservation projects, primarily thought that these environments are growing both in number and importance. There are a lot of population traits for evaluating the population’s status, such as the abundance, recruitment and survival rate, all methods very dispendious of an effort level. Here we investigated the influence of environmental variables on the physiological body condition of Bombina variegata (yellow-bellied toad) in three different habitat typologies, Natural, Mountain pasture and Agricultural, in the Province of Trento, Northern Italy. These habitats differ in their genesis, development and maintenance. The natural sites are unaffected by human impact, the Mountain pasture pond are semi-natural environments whose maintenance, however, depends on human intervention (periodic removal of substrate to prevent silting) and subject to cows trampling, in the end the agricultural sites are artificial cemented tank used by farmer as water reservoir. The species shows decreasing trend following the IUCN assessment but it has a fairly well distribution in the study area. We used the Scaled Mass Index (SMI), considering snout-vent length and body weight of toads, as a measure of the population’s body condition. SMI was calculated for 932 male toads belonging to 9 populations that were monitored for 5 consecutive years. We found that toads in Natural Habitat had significantly better body condition than those in both Mountain pasture habitat () and Agricultural one (), indicating that Natural habitat provided particularly higher quality habitat. SMI allows for the assessment of individuals persisting in disturbed environments, providing valuable information on environmental suitability, which is a primary objective of conservation.
“The Significance of the Local Church”
Authors: Tyson Catherine 
Published: February 2025

Abstract
Since the start of the war in Ukraine, Patriarch Kirill, head of the Russian Orthodox Church (ROC), has faced criticism for providing religious justification for Russia’s invasion. This study provides foundational research on how the war and the patriarch’s statements are impacting attitudes toward church attendance at ROC parishes in France and the U.S. Based on twenty-seven qualitative interviews across seven parishes, this research explores the central reasons churchgoers hold for continuing to attend ROC parishes, despite many disagreeing with the patriarch’s stance on the war. Reasons for staying center around viewing the local church as a place of worship and community.
Make space! Creating Church with Newcomers
Authors: Felter Kirsten Donskov , Berg Berit Weigand , Hansen Heine Lokjaer 
Published: February 2025

Abstract
In the Evangelical Lutheran Church of Denmark, demographic changes call for new strategies to integrate groups of newcomers in already existing parishes. In 2019, Skalborg, a rapidly growing parish on the outskirts of the city of Aalborg, together with the independent organization Kirkefondet and Centre for Pastoral Education and Research, initiated the project ‘Church with Newcomers’ that seeks to involve new citizens actively in creating relevant forms of church in a new city district. The evaluation of the project team made clear that openness and inclusiveness were seen as core qualities of the project that indicated that this was church. The article explores how the collaborative design and culture of the project team have contributed to realizing the project’s aim. We argue that working with space-making practices may point to fruitful ways of realizing participatory ecclesiology in a changing folk church setting.
Possible behavioral hierarchy in the food handling by Messor arenarius ants
Authors: Warburg Ittai 
Published: February 2025

Abstract
Messor arenarius ants are seed harvesters, that feed mainly on seeds or plant parts. This species inhabits mainly deserts in the Middle East and North Africa. In Israel, M. arenarius ants can be found in the Negev Desert and also in the Coastal Plain. This research focuses on the food-handling stages of those ants. Using food choice experiments, ants were given choices, to select between whole-wheat seeds and halves of wheat seeds cut longitudinally. In first collection rounds, the proportion of cases in which ants touched both food items using their antennae was significantly higher than forelegs touches. Similar findings were obtained in further collection rounds, when the sand or the soil at the food collection points was swept or changed after each collection round. These findings indicate a hierarchy between the food handling by the antennae and the food handling by the forelegs in M. arenarius ants. It seems that those ants smell food items by their antennae, which contain contact chemoreceptors, and afterward feel those food items by their forelegs, which contain mechanoreceptors.
The Imminent Data Desert: The Future of Stratospheric Monitoring in a Rapidly Changing World
Authors: Salawitch Ross J. , Smith Jessica B. , Selkirk Henry , Wargan Krzysztof , Chipperfield Martyn P. , Hossaini Ryan , Levelt Pieternel F. , Livesey Nathaniel J. , McBride Laura A. , Millán Luis F. , Moyer Elisabeth , Santee Michelle L. , Schoeberl Mark R. , Solomon Susan , Stone Kane , Worden Helen M. 
Published: February 2025

Abstract
The Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS) on SCISAT-1 and Microwave Limb Sounder (MLS) on NASA’s Aura satellite have contributed significantly to understanding the impacts of human activities on the stratospheric ozone layer. The two-decade-long data record from these instruments has allowed quantification of ozone depletion caused by human-released ozone-depleting substances, the effects of extreme natural events like major volcanic eruptions including Hunga in 2022, as well as events amplified by human-caused climate change such as wildfires that inject material into the stratosphere, as happened over Australia in early 2020. Both platforms are nearing the end of their operational lifetimes, and their decommissioning will cause a substantial gap in the measurement of critical atmospheric components, including water vapor, inorganic chlorine species, and tracers of stratospheric transport. This upcoming “data desert” poses significant challenges for monitoring the recovery of the ozone layer and assessing the effects on stratospheric composition of future extreme events, threats posed by increases in space debris from satellite burn-up, and the possible injection of stratospheric aerosol to mitigate global warming. The lack of confirmed future missions that can provide daily near-global profile measurements of stratospheric composition highlights the need for observational strategies to bridge this impending gap. This paper discusses the essential role of ACE-FTS and MLS in advancing our understanding of the stratosphere, the impact of data loss after the cessation of one or both instruments, and the urgency of developing strategies for mitigating the impact of these observational losses at a time marked by dramatic changes in the stratosphere due to human and natural factors.
Impacts of Background Conditions on the Evolutionary Disparities between Greenland and Euro-Atlantic Blocking
Authors: Zhang Wenqi , Wang Lin , Luo Dehai , Yao Yao , Luo Binhe , Simmonds Ian , Semenov Vladimir 
Published: February 2025

Abstract
In this paper, we investigate the contrasting evolutionary behaviors and weather impacts of Greenland blocking and Euro-Atlantic blocking. The comprehensive analysis reveals that Greenland blocking is characterized by substantial amplitude, a prolonged lifespan, and notable westward movement, accompanied by significant warming over western Greenland and cooling over eastern North America and northern Europe. In contrast, Euro-Atlantic blocking remains quasi stationary, has a shorter duration, and features a smaller amplitude, resulting in only mild cooling over southern Europe. We elucidate the dynamic mechanism behind the evolution of these two types of blockings using the nonlinear multiscale interaction model of atmospheric blocking from the perspective of the meridional gradient of potential vorticity PVy. Here, atmospheric blocking is conceptualized as a wave packet comprising an envelope and a carrier wave. In contrast to Euro-Atlantic blocking, the wave packet envelope (WPE) of Greenland blocking displays a greater degree of nonlinearity and weaker high-order dispersion under weak background zonal wind and PVy conditions. This fosters the amplification and sustainability of the WPE, contributing to its large amplitude and extended lifespan. Greenland blocking also shows pronounced westward movement due to its large amplitude and the weak background PVy condition. The Euro-Atlantic blocking exhibits quasi-stationary and small-amplitude behaviors due to strong zonal wind and PVy conditions. Our findings indicate that the discrepancy in system dispersion, i.e., the relative velocity of the WPE and the carrier wave, between Greenland blocking and Euro-Atlantic blocking is negligible. The results emphasize that the variance in their evolutionary behaviors primarily stems from disparities in their WPEs.
USE OF PUBLIC EMERGENCY DENTAL SERVICES BY CHILDREN IN TIRGUMURES, ROMANIA
Authors: SzÉkely M. , DÖrner K. , Nagy M. , Bors A. , Vass H. 
Published: February 2025

In Romania, dental health services are provided mainly through user pays private practices and there is limited reimbursement of dental services for children from the government. The economic recession lead to substantial lack of insurance coverage for oral health care of low-income populations. Aim: The aim of the study was to assess the impact of changes in the reimbursement of dental services on the demand for publicly funded emergency dental care for children provided by the Mures County Emergency Hospital, in the Mobile Emergency Service for Resuscitation and Extrication (MESRE), in Tirgu-Mures, Romania. Methods: This four-year retrospective study was based on the analysis of patient’s dental records. Included in the study were all patients requesting emergency dental care at MESRE Dental Office in Tirgu- Mures since its establishment in 1st of February 2012. The study was approved by the Research Ethics Committee of the University of Medicine and Pharmacy of Tirgu-Mures. Data were analysed using SPSS v 17 for Windows descriptive statistics. Student t-test was used and the significance level was set at p<0.05. Results: During the study period a total of 26949 patients were treated in the emergency dental office and the proportion of children (aged 0-18- years) was 5169 (19.2%). Compared to the first year of the service, the proportion of emergency dental care visits was significantly higher in all other years, particularly in the period when dental care for children was not reimbursed by the public system (p<0.05). However, the highest rate of emergency dental visits was observed in the last year 1524 (22.2%). Conclusions: The results highlighted that dental services for children were influenced by changing state insurance schemes. The high demand for emergency dental care reflects the need for community based public dental care in Tirgu-Mures, Romania.
INFLUENCE OF PARENT’S EDUCATION ON SELF-PERCEIVED ORAL HEALTH IN CHILDREN
Authors: Sozovska-Stojanovikj E. , Getova B. , Stojanovikj P. , Janevska S. , Miloshevski N. 
Published: February 2025

Parental socioeconomic characteristics are related to their children’s subjective perception on oral health. Aim: To correlate the educational level of each parent, an individual-level indicator of socio-economic status (SES): with self-perceived oral health in a 12-year-olds in the region of Skopje. Method: Cross-sectional design. The study sample was randomly drawn with a two-stage cluster sample from 12 year olds from the capital town of Macedonia-Skopje. The study was conducted in November- December 2015. Data were collected by the adapted and translated WHO Oral Health Questionnaire for children. Participation was voluntary and consent to participation was given by completing and returning the questionnaire. Of 307 questionnaires, 218 were returned. Since the questionnaire was used as a part of the National survey of oral health of 12 year olds in Macedonia, as part of an audit of the national programme, it did not require separate ethics approval. The data analysis was carried out by IBM SPSS Statistics 20. Results: The study included 218 children (71% response rate) in total, 103(47.2%) male and 115(52.8%) female. Out of all the children who rated their teeth and gums health as excellent/very good, 66(71%), 77(67.5%) respectively, had mothers with a university degree. The children who rated their teeth and gums health as fair/poor, 84.7%, 85.7% respectively, had mothers with an education level below a university degree. Conclusions: The mother’s educational level had an impact on children’s subjective perception of oral health. Children living with parents with higher educational level generally report better oral hygiene behaviors, access to health care and preventive interventions. The present study shows that parents educational level could be a useful individual SES indicator for oral health in children and health managers might use this factor when planning oral health promotion interventions.
CHANGES IN ADULTS’ HABITUAL VISITS TO A DENTIST
Authors: Torppa-Saarinen E.M. , Tolvanen M.M. , Lahti S.M. , Suominen A.L. 
Published: February 2025

Aim: To evaluate changes in habitual use of dental services by gender and age groups in an adult population during 11 years in a nationally representative setting. Methods: The data were collected by interviews as a part of the Health 2000 and Health 2011 programmes, during which 7,964 Finnish adults aged ≥ 30 years were surveyed. The Ethics Committees of the National Public Health Institute and University Hospital Region of Helsinki, Finland gave permission to these National Surveys. The participants were asked if they visited dentist: regularly for checkups, or only when having pain or other trouble, or never. The first option indicated habitual and the last two non-habitual visits to a dentist. The participants were categorized according to their year of birth: born 1971 of after, 1956-1970, 1946-1955 and 1945 or before. The changes were evaluated with cross-tabulation and the McNemar-test. Results: 4,053 participants (51%) answered the question in both years. Habitual use of dental services was more common among women (66% in 2000 and 69% in 2011) than among men (53% in 2000 and 57% in 2011). The proportion of those reporting habitual visits changed according to age and gender as follows: among men born 1971 or later from 42% to 52% (p=0.009), among women born 1971 or later from 59% to 66% (p=0.057), among men born 1956-70 no change, 56% in both years (p=0.604), among women born 1956-70 from 70% to 72% (p=0.267), among men born 1946-55 from 54% to 64% (p<0.001), among women born 1946-55 from 70% to 72% (p=0.456), among men born 1945 or before from 59% to 55% (p=0.193) and among women born 1945 or before from 62% to 65% (p=0.223), i.e. the changes in habitual use were statistically significant only among men in two age groups. Conclusions: The changes in habitual visits to a dentist were not substantial. Habitual service use was the pattern among the majority of adults in all age groups and among both genders during the 11 year period. Partly supported by the Finnish Dental Society Apollonia.
CHILDSMILE DENTAL HEALTH SUPPORT WORKERS IMPACT ON CHILD DENTAL PARTICIPATION IN SCOTLAND
Authors: Hodgins F. , Conway D. , Gnich W. , Macpherson L. , Sherriff A. 
Published: February 2025

Childsmile, a Scottish government funded national public health programme, aims to improve child oral health and reduce oral health inequality. Dental Health Support Workers (DHSWs) form one of the programme’s targeted strategies; primarily aiming to facilitate parents to access dental services for their children in the early years. Aim: This study measured the impact DHSWs had on child registration and attendance with dental practice, investigating whether this was similar across social groups. Method: National level data from three administrative health datasets were linked, including: 1) Child Health assessments (September 2010-December 2012) (n=111,909); 2) Health Informatics Centre data on DHSW contact with (referred) families (September 2010 -September 2012) (n=18,392), and 3) Management Information and Dental Accounting System data on dental participation (registration and/ or attendance) (September 2010-December 2013) (n=76,724). Analysis was undertaken through a secure research portal. Multivariable logistic regression models were used to analyse the effect of DHSW intervention on participation, and whether there was any modification of this effect according to area-based deprivation (using Scottish Index of Multiple Deprivation (SIMD) 2009). Survival analysis was used to analyse time to participation at dental practice. This study was NHS Privacy Advisory Committee (now the Public Benefit and Privacy Panel) approved. Results: Preliminary results show that, across the whole population, 80.8% (n=14852/18392) of those who received a DHSW intervention participated at dental practice compared to 66.2% (n=61872/93517) who did not receive an intervention (OR=2.1, 95% CI [2.1 to 2.2], p<0.0001). This effect was slightly modified when stratified by area-based deprivation: In children living in the 20% most deprived areas of Scotland, participation was 77.6% (n=12417/20494) for those receiving the intervention vs. 60.6% (5908/7614) for those not. For those living in the 20% least deprived areas the figures were: 84.0% (1178/1403) vs. 69.8% (11607/16631), respectively (p for interaction=0.25). Survival analysis showed that the median age when a child first participated at dental practice was 9 months for those who received a DHSW intervention and 19 months for those who did not. Conclusions: Participation rates at dental practice were higher for families who received the DHSW intervention, compared to those who did not, the effect only slightly stronger for those living in more deprived areas. Participation at dental practice was facilitated sooner for children receiving DHSW support. Ongoing work is addressing whether these benefits translate to a clinically important reduction in inequalities in oral health.