bluuebunny/crossref_metadata_2025_split huggingface dataset:
They just don't take their medicines: Reframing medication adherence in asthma from frustration to opportunity
Authors: De Keyser Heather Hoch , Ramsey Rachelle , Federico Monica J. 
Published: January 2020

AbstractAssessing and addressing suboptimal adherence to asthma medications is a key component in the treatment of all children with asthma, particularly those with difficult‐to‐treat asthma. However, parents often overreport adherence to asthma medications. Increased medication adherence could lead to improved outcomes in the form of better asthma control and decreased asthma exacerbations, as well as decreased healthcare utilization costs. Yet there are many complex factors that affect medication adherence, and barriers are often different in each family. Social determinants of health, complex healthcare relationships, and patient‐related factors may all affect medication adherence. Multicomponent patient‐centered strategies, as well as strategies that utilize technology and habit formation strategies may be helpful in improving medication adherence. Further study is needed to reliably and sustainably improve medication adherence in children with asthma across the broader population; in some populations, alternate diagnoses, adjusting therapy, and other intervention may be required to improve asthma control and health.
Bringing semantics to multicloud service compositions
Authors: Ghazouani Souad , Mezni Haithem , Slimani Yahya 
Published: January 2020

SummaryOver the last decade, cloud computing has emerged as a new paradigm for delivering various on‐demand virtualized resources as services. Cloud services have inherited not only the major characteristics of web services but also their classical issues, in particular, the interoperability issues and the heterogeneous nature of their hosting environments. This latter problem must be taken into account when composing various cloud services, in order to answer users' complex requirements. Moreover, leading cloud providers started to offer their services across multiple clouds. This adds a new factor of heterogeneity, as composition engines must take into consideration the heterogeneity not only at the service level (eg, service descriptions) but also at the cloud level (eg, pricing models, security policies). In this context, the semantics of multicloud actors must be incorporated into the multicloud service composition (MCSC) process. However, most existing approaches have treated the semantic service composition in traditional single‐cloud environments. The few works in multicloud settings have ignored the semantics of cloud zones and resources. Moreover, they often focus on the general aspect of MCSC (eg, horizontal or vertical compositions). Even the few researchers who have addressed both vertical and horizontal service compositions, conducted their research studies in the context of single‐ cloud environments, which were proven to be unrealistic and offer limited quality of service (QoS) and security support. To ensure a high interoperability when composing services from multiple heterogeneous clouds and to enable a horizontal/vertical semantic service compositions, we take advantage of a standardized and semantically enriched generic service description, including all aspects (technical, operational, business, semantic, contextual) and supporting different cloud service models (SaaS, PaaS, IaaS, etc). We also incorporate Semantic Web Rule Language into the MCSC process to enable not only rule‐based reasoning about various composition constraints (eg, QoS constraints, cloud zones constraints) but also to provide accurate semantic matching of cloud services' capabilities. Conducted experiments have proven the ability of our approach to combine high‐quality services from the optimal number of clouds.
Solvent accessibility limitation by plant matrix compounds in extraction of rutin from Solanum lycopersicum
Authors: Lück Manuel , Bergs Frederik , Jupke Andreas 
Published: January 2020

AbstractExtraction procedures for plant‐based secondary metabolites are mainly influenced by choice of solvent, particle size and solvent to feed ratio. For developing an extraction protocol design‐of‐experiments or model‐based approaches have widely been used. Botanical aspects such as the influence of side compounds are less investigated. Either for analytical or preparative purposes, knowledge of the underlying extraction mechanisms is required to improve the process development. In this work, we demonstrate the mechanism of accessibility limitation of rutin by side compounds depending on the solvent to feed ratio. Extraction yields of target and side compounds are analyzed to derive correlations. The role of side compounds as limiting factors for target compound accessibility is demonstrated by performing two extraction steps using three different plant species. The maximum extraction yield of rutin is reached using a solvent to feed ratio of at least 300 for all three investigated plant species, while side compounds in liquid state generally affect the extractability of rutin. Phosphatidylcholines are identified as possible accessibility‐limiting compounds. In conclusion, the yields of target and side compounds strongly depend on the solvent to feed ratio, while side compounds cover the target compound in dry matter, reducing its accessibility.
Improving the wind‐induced human comfort of the Beijing Olympic Tower by a double‐stage pendulum tuned mass damper
Authors: Chen Xin , Li Aiqun , Zhang Zhiqiang , Hu Liang , Sun Peng , Fan Zhong , Liu Xianming 
Published: January 2020

SummaryWith five sub towers and a maximum height of 246.8 m, the Beijing Olympic Tower (BOT) is a landmark of Beijing. The complex structural properties and slenderness of the BOT render it prone to wind loading. As far as the wind‐induced performance of this structure is concerned, this paper thus aims at a tuned mass damper‐based mitigation system for controlling the wind‐induced acceleration response of the BOT. To this end, the three‐dimensional wind loading of various wind directions are simulated based on the fluctuating wind force obtained by the wind tunnel test, by which the wind‐induced vibration is evaluated in the time domain by using the finite element model. A double‐stage pendulum tuned mass damper (DPTMD), which is capable of controlling the long period dynamic response and requires only a limited space of installation, is optimally designed at the upper part of the tower. Finally, the wind‐induced response of the structure with and without DPTMD is compared with respect to various wind directions and in both the time and frequency domains. The comparative results show that the wind‐induced accelerations atop the tower with the wind directions of 45, 135, 225, and 315° are larger than those with the other directions. The DPTMD significantly reduces the wind‐induced response by the maximum acceleration reduction ratio of 30.05%. Moreover, it is revealed that the control effect varies noticeably for the five sub towers, depending on the connection rigidity between Tower1 and each sub tower.
Impact of different forest densities on atmospheric boundary‐layer development and wind‐turbine wake
Authors: Adedipe Taiwo A. , Chaudhari Ashvinkumar , Kauranne Tuomo 
Published: January 2020

AbstractThe aim of this work is to investigate the atmospheric boundary‐layer (ABL) flow and the wind turbine wake over forests with varying leaf area densities (LAD). The forest LAD profile used in this study is based on a real forest site, Ryningsnäs, located in Sweden. The reference turbine used to model the wake is a well‐documented 5‐MW turbine, which is implemented in the simulations using an actuator line model (ALM). All simulations are carried out with openFOAM using the Reynolds averaged Navier‐Stokes (RANS) approach. Twelve forest cases with leaf area index (LAI) ranging from 0.42 to 8.5 are considered. Results show that the mean velocity decreases with increasing LAI within the forest canopy, but increases with LAI above the hub height. Meanwhile, the turbulent kinetic energy (TKE) varies nonmonotonically with forest density. The TKE increases with forest density and reaches to its maximum at an average LAI of 1.70, afterwards, it decreases gradually as the density increases. It is also observed that the forest density has a clear role in the wake development and recovery. Comparisons between no‐forest and forest cases show that the forest characteristics help in damping the added turbulence from the turbine. As a consequence, the forest with the highest upstream turbulence has the shortest wake downstream of the turbine.
Disturbance observer‐based integral sliding mode control for wind energy conversion systems
Authors: Suleimenov Kanat , Sarsembayev Bayandy , Duc Hong Phuc Bui , Do Ton Duc 
Published: January 2020

AbstractRecently, wind power production has been under the focus in generating power and became one of the main sources of alternative energy. Generating of maximum power from wind energy conversion system (WECS) requires accurate estimation of aerodynamic torque and uncertainties presented in the system. The current paper proposed the generalized high‐order disturbance observer (GHODO) with integral sliding mode control (ISMC) for extraction of maximum power via variable speed wind turbine by accurate estimation of wind speed. The assumption in previous works that considers the aerodynamic torque as slow‐varying is not applicable for the real system. Therefore, the high‐order disturbance observers were designed for precise estimation of uncertainties with fast‐changing behavior. A robust control system was designed to control the speed of the rotor at the optimal speed ratio. The obtained simulation results have shown the better performance characteristics than conventional linear quadratic regulator (LQR) approach. The stability of the proposed algorithm was proven by Lyapunov stability anaysis. Simulations results were obtained in Matlab/Simulink environment.
An alternative to diagrams for the critical O(N) model: dimensions and structure constants to order 1/N2
Authors: Alday Luis F. , Henriksson Johan , van Loon Mark 
Published: January 2020

Abstract
We apply the methods of modern analytic bootstrap to the critical O(N) model in a 1/N expansion. At infinite N the model possesses higher spin symmetry which is weakly broken as we turn on 1/N. By studying consistency conditions for the correlator of four fundamental fields we derive the CFT-data for all the (broken) currents to order 1/N, and the CFT-data for the non-singlet currents to order 1/N2. To order 1/N our results are in perfect agreement with those in the literature. To order 1/N2 we reproduce known results for anomalous dimensions and obtain a variety of new results for structure constants, including the global symmetry central charge CJ to this order.
The holographic dual of the entanglement wedge symplectic form
Authors: Kirklin Josh 
Published: January 2020

Abstract
In this paper, we find the boundary dual of the symplectic form for the bulk fields in any entanglement wedge. The key ingredient is Uhlmann holonomy, which is a notion of parallel transport of purifications of density matrices based on a maximisation of transition probabilities. Using a replica trick, we compute this holonomy for curves of reduced states in boundary subregions of holographic QFTs at large N, subject to changes of operator insertions on the boundary. It is shown that the Berry phase along Uhlmann parallel paths may be written as the integral of an abelian connection whose curvature is the symplectic form of the entanglement wedge. This generalises previous work on holographic Berry curvature.
Leading multi-stress tensors and conformal bootstrap
Authors: Karlsson Robin , Kulaxizi Manuela , Parnachev Andrei , Tadić Petar 
Published: January 2020

AbstractNear lightcone correlators are dominated by operators with the lowest twist. We consider the contributions of such leading lowest twist multi-stress tensor operators to a heavy-heavy-light-light correlator in a CFT of any even dimensionality with a large central charge. An infinite number of such operators contribute, but their sum is described by a simple ansatz. We show that the coefficients in this ansatz can be determined recursively, thereby providing an operational procedure to compute them. This is achieved by bootstrapping the corresponding near lightcone correlator: conformal data for any minimal­ twist determines that for the higher minimal-twist and so on. To illustrate this procedure in four spacetime dimensions we determine the contributions of double- and triple-stress tensors. We compute the OPE coefficients; whenever results are available in the literature, we observe complete agreement. We also compute the contributions of double-stress tensors in six spacetime dimensions and determine the corresponding OPE coefficients. In all cases the results are consistent with the exponentiation of the near lightcone correlator. This is similar to the situation in two spacetime dimensions for the Virasoro vacuum block.
Peak Ground Motions and Site Response at Anza and Imperial Valley, California
Authors: Fletcher Jon B. , Boatwright John 
Published: January 2020

AbstractPower spectra of shear-waves for eighteen earthquakes from the Anza-Imperial Valley region were inverted for source, mid-path Q, site attenuation and site response. The motivation was whether differences in site attenuation (parameterized ast*, r/cQ,whereris distance along ray path near the site,cis shear velocity andQis the quality factor that parameterizes attenuation) and site response could be correlated with residuals in peak values of velocity or acceleration after removing the affect of distance-dependent attenuation. We decomposed spectra of S-waves from horizontal components of 18 earthquakes from 2010 to 2018 into a common source for each event with ω−2spectral fall-off at high frequencies and then projected the residuals onto path and site terms following the methodology of Boatwright et al. (Bull Seismol Soc Am 81:1754–1782, 1991). The site terms were constrained to have an amplification at a particular frequency governed by VS30at two of the sites which had downhole shear-wave logs. The 18 events, 3 < M < 4, had moments between approximately 1020and 1022 dyne-cm, and stress drops between 1 and 100 bars. Average mid-crust attenuation had a Q of 844 reflecting the average path through the crystalline rock of the San Jacinto Mountains.t*for each station corresponded to the geologic environment such that stations on hard rock had lowt*(e.g. stations KNW, PFO and RDM) a station in the San Jacinto fault zone (station SND) had a moderatet*of 0.035 s and stations in the Imperial Valley usually had highert*s. Generallyt*correlated with average amplification suggesting that sites characterized by low surface velocities and higher attenuation also have more amplification in the 1–6 Hz band. Residuals of peak values were determined by subtracting the prediction of Boore and Atkinson (2008). There is a correlation between average amplification and peak velocity, but not peak acceleration. Interestingly, there is less scatter at high values of amplification although there is also less data. Scatter in values of peak velocity and peak acceleration are higher at shorter compared to longer durations. When using a frequency-dependent form forQ, variances are higher, sometimes much higher; the dataset does not support frequency-dependentQ, which is not similar to results from the Imperial Valley and northeastern North America.
Real-time atmospheric extinction variation analysis with the Photometric Telescope at Xinglong Observatory
Authors: Zhao Yong , Fan Zhou , Ge Liang , Ren Juanjuan , Tian Jianfeng , Wang Jianfeng , Qiu Peng , Jiang Xiaojun 
Published: January 2020

AbstractWe present the Photometric Auxiliary System (PAS) attached to the 25-cm Photometric Telescope (PT) at Xinglong Observatory of National Astronomical Observatories, Chinese Academy of Sciences (NAOC). This PAS can provide real-time atmospheric extinction for other telescopes at the same station for flux calibration via observing standard stars, e.g. the 2.16-m reflector and 1-m telescope. Moreover, the real-time atmospheric extinction could act as a useful reference for other local telescopes regarding the adjustment of observing strategies, such as changing the exposure time, which is important for the observers. This PAS has been operated since February 2012, and we have obtained the $r$r-band atmospheric extinction of Xinglong Observatory from February 2012 to March 2018. With these data, we have analyzed the atmospheric extinction of Xinglong Observatory in detail.
Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study
Authors: von Stemann Jakob H. , Pedersen Ole B. , Hjalgrim Henrik , Erikstrup Christian , Ullum Henrik , Thørner Lise W. , Larsen Margit AH. , Burgdorf Kristoffer S. , Sørensen Erik , Hansen Morten B. , Ostrowski Sisse R. 
Published: January 2020

AbstractThe presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected pathologies. However, the overall influence of c-aAb on immunocompetence remains largely unknown. In this paper, we performed a large-scale investigation of c-aAb association with infection risk. A cohort of healthy Danish blood donors was screened for c-aAb against IL-1α, IL-6, IL-10, IFNα, and GM-CSF using a Luminex-based multiplex assay, and results were linked to data from the Danish National Prescription Registry. The filing of an antimicrobial prescription following c-aAb measurement was used as a proxy for impaired immunocompetence. We found that c-aAb against pro-inflammatory cytokines IFNα and GM-CSF tended to associate with increased risk of prescription filings in women, whereas antibodies against anti-inflammatory IL-10 were associated with a lower predicted risk of antimicrobial prescriptions, as well as higher self-perceived health scores. We also observed an association of cumulative c-aAb presence with prescription risk. Our data show that cytokine autoantibodies in healthy individuals associate with various proxies for immunomodulation, with the exact association dependent on the pattern of pro- or anti-inflammatory cytokines targeted. This suggests that c-aAb may express cytokine-modulatory properties in healthy individuals and may be critical to further investigate as biomarkers of immunodeficiency.
Mental Health in the UK Police Force: a Qualitative Investigation into the Stigma with Mental Illness
Authors: Edwards Ann-Marie , Kotera Yasuhiro 
Published: January 2020

AbstractPolice work is a high-risk profession that can cause mental health conditions. With increasing sickness levels and falling police numbers, it is essential prompt mental health treatment be implemented. The study aims to explore institutional negativity and stigma in the police force towards mental ill health. Semi-structured interviews attended by five police officers with thematic analysis captured (i) police culture, (ii) the stigma of mental illness, (iii) disclosure of mental illness and (iv) breaking down barriers. Findings indicate police culture and attitudes to mental health may contribute to the causes of psychological illness, rather than the nature of the job itself. Increased education and awareness surrounding mental health have been shown to be fundamental in how an officer reacts to stress, but change is needed at a managerial level. Future research needs to explore the effects of mental health stigma on ethnicity and gender in the police force.
Type of cancer treatment and cognitive symptoms in working cancer survivors: an 18-month follow-up study
Authors: Ehrenstein Johanna K. , van Zon Sander K.R. , Duijts Saskia F.A. , van Dijk Boukje A.C. , Dorland Heleen F. , Schagen Sanne B. , Bültmann Ute 
Published: January 2020

Abstract
Purpose
Cognitive symptoms are reported to affect cancer survivors’ functioning at work. However, little is known about the type of cancer treatment and cognitive symptoms in working cancer survivors. We examined the longitudinal association between type of cancer treatment and cognitive symptoms in cancer survivors post return to work, and whether the course of cognitive symptoms over 18 months differed per type of cancer treatment.

Methods
Data from the Dutch longitudinal “Work-Life after Cancer” study were used. The study population consisted of 330 working cancer survivors who completed questionnaires at baseline, and 6, 12, and 18 months follow-up. Cognitive symptoms were assessed with the cognitive symptom checklist-work and linked with cancer treatment data from the Netherlands Cancer Registry. Data were analyzed using generalized estimating equations.

Results
Cancer survivors who received chemotherapy reported comparable memory symptom levels (b: − 2.3; 95% CI = − 7.1, 2.5) to those receiving locoregional treatment. Executive function symptom levels (b: − 4.1; 95% CI = − 7.8, − 0.4) were significantly lower for cancer survivors who received chemotherapy, compared with those receiving locoregional treatment. In cancer survivors who received other systemic therapy, memory (b: 0.4; 95% CI = 0.1, 0.7) and executive function symptom levels (b: 0.4; 95% CI = 0.0, 0.7) increased over time. In cancer survivors who received chemotherapy and locoregional treatment, memory and executive function symptom scores were persistent during the first 18 months after return to work.

Conclusions
The contradictory finding that cancer patients receiving chemotherapy report fewer cognitive symptoms warrants further research.

Implications for Cancer Survivors
Working cancer survivors may have cognitive symptom management needs irrespective of the type of cancer treatment they received.
Complete remission of disseminated Langerhans cell sarcoma after stem cell transplantation
Authors: Schlintl Verena , Schlick Konstantin , Russ Gudrun , Gampenrieder Simon Peter , Monzo Fuentes Claudia , Kos Tea , Renneberg Felix , Rettenbacher Lukas , Gradl Johann , Sotlar Karl , Hoffmann Alexander , Greil Richard 
Published: January 2020

SummaryWith fewer than 100 cases described in the English literature so far, Langerhans cell sarcoma represents an orphan malignant disease deriving from histiocytic cells. Clinical course is extremely aggressive and associated with poor survival rates, especially in disseminated condition. Herein, we describe the case of a young patient with fulminant development of metastatic Langerhans cell sarcoma, who achieved persistent remission after polychemotherapy and subsequent high-dose chemotherapy with autologous stem cell transplantation.
Evaluation of NDVI Estimation Considering Atmospheric and BRDF Correction through Himawari-8/AHI
Authors: Seong Noh-Hun , Jung Daeseong , Kim Jinsoo , Han Kyung-Soo 
Published: January 2020

AbstractSatellite-based vegetation indices are an essential element in understanding the Earth’s surface. In this study, we estimated the normalized difference vegetation index (NDVI) using Himawari-8/Advanced Himawari Imager (AHI) data and analyzed the sensitivity of products to atmospheric and surface correction. We used the Second Simulation of a Satellite Signal in the Solar Spectrum (6S) radiative transfer model for atmospheric correction, and kernel-based semi-empirical bidirectional reflectance distribution function (BRDF) model to remove surface anisotropic effects. From this, top-of-atmosphere, top-of-canopy, and normalized NDVIs were produced. A sensitivity analysis showed that the normalized NDVI had the lowest number of missing values compared with the others and almost no low peaks during the study period. These results were validated by Terra and Aqua/Moderate Resolution Imaging Spectroradiometer (MODIS) and Project for On-Board Autonomy/Vegetation (PROBA) NDVI product, showing the root mean square error (RMSE) and bias of 0.09 and + 0.04 (MODIS) and 0.09 and − 0.04 (PROBA), respectively. These results also satisfied the FP7 Geoland2/BioPar project-defined user requirements (threshold: 0.15; target: 0.10).