bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Stomatognathic System Adapt to Changes in Occlusion? Best Evidence Consensus Statement
Authors: Goodacre Charles J. , Roberts W. Eugene , Goldstein Gary , Wiens Jonathan P. 
Published: December 2020

AbstractPurposeThe purpose of this Best Evidence Consensus Statement was to evaluate the existing literature on the stomatognathic system's ability to adapt to occlusal changes.Materials and MethodsThe search term stomatognathic system was not useful as it resulted in over 400,000 results nor was the search term temporomandibular joint adaptation with 738 results due to the large number of references not related to the topic. The terms stomatognathic system adaptation to occlusal changes (186 results), teeth flexion (139 results), muscle adaptation to dental occlusion (278 results), and occlusal changes and neuroplasticity (11 results) provided the best selection of articles related to the topic. Limiting the above searches to systematic reviews and randomized controlled clinical trials resulted in multiple publications that were related to the question. Other literature reviews, data‐based publications, and expert opinion resources have been included due to their relationship to the question.ResultsFrom the extensive list of search results, 242 articles were determined to be potentially related to the focus question and were evaluated with 56 being included in this paper. It was determined that the stomatognathic system adapts to occlusal changes through the temporomandibular joint, muscles, teeth and bone. The dynamically modified periosteum on the articulator surfaces of the condyle and fossa has a unique load‐bearing morphology with 3 subarticular layers of fibrocartilage that absorb and dissipate both peak (impact) and sustained loads. Adaptability of the TMJs and muscles can be documented through studies where artificially produced occlusal interferences were placed in patients and those study participants with normal temporomandibular joints (TMJs) adapted fairly well whereas those with a previous history of temporomandibular disorders (TMD) did not adapt as well.ConclusionsAvailable evidence indicates patients generally adapt to the occlusal change inherent in orthodontic treatment, mandibular advancement surgery, and the use of mandibular advancement devices. The head and neck muscles also adapt to occlusal changes in patients without a history of TMD. The dentition adapts to changes through the bone and periodontal ligaments as well as the ability of teeth to undergo slight flexion under masticatory loading.
Intersecting sexual identities, oppressions, and social justice work: Comparing LGBTQ Baby Boomers to Millennials who came of age after the 1980s AIDS epidemic
Authors: Hagai Ella Ben , Annechino Rachelle , Young Nicholas , Antin Tamar 
Published: December 2020

AbstractIn this study, we analyze 50 interviews with racially diverse, predominantly low‐income, LGBTQ participants living in the San Francisco Bay Area. Rooted in intersectional theory that conceptualizes identities as shaped by interlocking forms of oppression and privilege, we compared interviews with “Baby Boomers” to those with “Millennial” participants, who came into adulthood in a time of greater legal and social inclusion for LGBTQ people. Our analysis focused on three questions: How do participants understand their sexual identities? How are the identities of sexual minority participants coconstructed with intersecting forms of oppression? What motivates LGBTQ people in our sample to engage in social justice work? We found that white LGBTQ people tended to see their sexualities as primary to their identity, compared to LGBTQ Black and/or Indigenous People of Color (BIPOC) who tended to see their identities in intersectional terms. Younger LGBTQ people were more likely to delink sex and gender identity; consequently, they were more likely to frame their sexual identities with terms not rooted in a gender binary (e.g., pansexual or queer). Experiences with homophobia were prevalent across generations, and intersected with racism and economic oppressions, but younger people more often described support from institutional agents. Participants’ sense of community and commitment to giving back after experiences of trauma motivated them to engage in social justice work. Our findings highlight the intersectional nature of oppressions faced by LGBTQ people and the need for organizations to move away from focusing exclusively on homophobic oppression as a monolith.
Phylogenetic relationships withinPyrenodesmiasensu lato and the role of pigments in its taxonomic interpretation
Authors: Frolov Ivan , Vondrák Jan , Košnar Jiří , Arup Ulf 
Published: December 2020

AbstractMost lichens of the family Teloschistaceae (Ascomycota) produce yellow‐orange‐red anthraquinone pigments. However, the genusPyrenodesmiaencompasses species in which anthraquinones are absent and replaced by a gray pigment Sedifolia‐gray. It was shown recently that these species are related to taxa with both anthraquinones and Sedifolia‐gray (Caloplaca xericagroup,C. haematitesgroup, andC.cretensis) and to species with a brown pigment instead of both anthraquinones and Sedifolia‐gray (C. demissa,C. obscurella, andC. reptans). Nevertheless, relationships between mentioned anthraquinone‐containing and anthraquinone‐lacking species remained unclear. In total, 8 DNA loci from 41 species were used here to resolve these uncertainties. We concluded thatC. demissa,C. obscurella, andC. reptansare rather distant from the core ofPyrenodesmia, and we place them outside ofPyrenodesmiasensu lato. WithinPyrenodesmiasensu lato, three lineages were revealed and recognized on a generic level: the genusPyrenodesmiasensu stricto (21 species), the genusKuettlingeria(14 species), which is resurrected here, and the genusSanguineodiscus(4 species), which is newly described here. The genusPyrenodesmiaincludes taxa that never contain anthraquinones, but Sedifolia‐gray. It matches with the formerC. variabilisgroup. Taxa of the generaKuettlingeriaandSanguineodiscushave anthraquinones in their apothecia and Sedifolia‐gray in their thalli. The genusKuettlingeriaincludes the formerC. xericagroup plusC. cretensisandC. diphyodes. The genusSanguineodiscusincludes the formerC. haematitesgroup andC. bicolor. The identity ofKuettlingeria(Caloplaca)diphyodeswas clarified and the namePyrenodesmia helygeoideswas resurrected. Twenty‐four new combinations were proposed.
A rapid review of stocking and marketing practices used to sell sugar‐sweetened beverages in U.S. food stores
Authors: Houghtaling Bailey , Holston Denise , Szocs Courtney , Penn Jerrod , Qi Danyi , Hedrick Valisa 
Published: December 2020

SummarySugar‐sweetened beverages (SSBs) are a primary source of added sugars in the American diet. Habitual SSB consumption is associated with obesity and noncommunicable disease and is one factor contributing to U.S. health disparities. Public health responses to address marketing‐mix and choice‐architecture (MMCA) strategies used to sell SSB products may be required. Thus, our goal was to identify original research about stocking and marketing practices used to sell SSB in U.S. food stores. We used Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) and the World Health Organization (WHO) protocol for rapid reviewing. We searched six databases and Google Scholar using key terms focused on store type and SSB products. We characterized results using an MMCA framework with categories place, profile, portion, pricing, promotion, priming or prompting, and proximity. Our search resulted in the identification of 29 articles. Most results focused on profile (e.g., SSB availability) (n = 13), pricing (e.g., SSB prices or discounts) (n = 13), or promotion (e.g., SSB advertisements) (n = 13) strategies. We found some evidence of targeted MMCA practices toward at‐risk consumers and differences by store format, such as increased SSB prominence among supermarkets. The potential for systematic variations in MMCA strategies used to sell SSB requires more research. We discuss implications for public health, health equity, and environmental sustainability.
Poor prognosis of food protein–induced enterocolitis syndrome to fish
Authors: Infante Sonsoles , Pérez‐Pallisé Esperanza , Skrabski Filip , Cabrera‐Freitag Paula , Morales‐Cabeza Cristina , Fuentes‐Aparicio Victoria , Alvarez‐Perea Alberto , Zubeldia José M. 
Published: December 2020

AbstractBackgroundFish is the most common causative food of food protein–induced enterocolitis syndrome (FPIES) in Southern Europe. In children with FPIES, the development of tolerance varies according to the culprit food and specifically fish seems to have a poorer prognosis than other solid foods. We sought to evaluate the fish‐FPIES resolution rate in children.MethodsA descriptive retrospective analysis of children with fish‐FPIES, followed during the last 20 years, was performed. The offending fish, age and symptoms at onset, the coexistence of atopic diseases and FPIES to other foods were registered. All the children included had undergone an oral food challenge (OFC) with the offending fish. We recorded those children that overcame their fish‐FPIES and those that did not outgrow the disease.ResultsSeventy children were enrolled in this study (median age: 9 yo; IQR 6.4‐13.8). Forty‐two (60%) achieved tolerance to the offending fish with a median age of 4 years (IQR: 3‐5). Among children ≤5 yo (n = 40), 35 (87.5%) developed tolerance; among 6‐8yo (n = 14), 40% developed tolerance; and only 12.5% among those ≥9 yo (n = 16) developed tolerance. Twenty‐eight children did not outgrow the disease (median age: 8.9 yo; IQR: 9‐13.8). We did not find any statistical differences regarding the offending fish, presence of single vs multiple fish‐FPIES, symptoms at the beginning, coexistence of other atopic diseases or the coexistence of other FPIES, between the children who overcame the disease and those who did not.ConclusionOne in five children with FPIES to fish will not overcome the disease during childhood.
Otitis media in children: Which phenotypes are most linked to allergy? A systematic review
Authors: De Corso Eugenio , Cantone Elena , Galli Jacopo , Seccia Veronica , Lucidi Daniela , Di Cesare Tiziana , Ottaviano Giancarlo , Sergi Bruno , Paludetti Gaetano , Fetoni Anna Rita 
Published: December 2020

AbstractBackgroundAllergic rhinitis is a common childhood disease responsible for a major impact on quality of life and healthcare resources. Many hypotheses have been proposed to explain the link between allergy and otitis media, although a definitive mechanism has not been identified yet. One of the major critical points is that authors failed in distinguishing among different phenotypes of middle ear inflammation. This review pointed out literature evidence from the laboratory and clinical experience linking allergy to different phenotypes of otitis media in children.MethodsWe performed a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) process. Our search yielded 3010 articles that were finally screened. This resulted in 20 manuscripts of which the full texts were included in a qualitative analysis. We paid particular attention in distinguishing among phenotypes of otitis media.ResultsClinical evidence and analyses of biomarkers suggested that allergy may be linked to some phenotypes of otitis media and, in particular, to otitis media with effusion (OME) and acute re‐exacerbations in children with middle ear effusion. It was not possible to perform the analysis for allergy and acute and chronic otitis media because of paucity and heterogeneity of data.ConclusionAllergy should be considered in the diagnostic workup of children with OME as well as OME should be excluded in children with persistent moderate to severe AR. In these cases, clinicians should evaluate prompt and accurate treatment of allergy in improving outcomes, although futures studies are required to increase evidence supporting that anti‐allergy treatment may be effective in the recovery and outcome of otitis media with effusion.
Percutaneous endovascular management of ascending aortic pseudoaneurysm after heart transplantation in a pediatric patient
Authors: Skrabonja‐Crespo Antonio , Chavarri‐Velarde Fernando , Pinto‐Salinas Miguel , Tauma‐Arrué Astrid 
Published: December 2020

AbstractAscending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten‐year‐old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two covered stents through endovascular management. Endovascular therapy is an alternative management in high‐risk patients. To our knowledge, this is the first report about endovascular therapy of an AAP after HT in a pediatric patient.
Umbilical cord mesenchymal stem cells as well as their released exosomes suppress proliferation of activated PBMCs in multiple sclerosis
Authors: Baharlooi Hussein , Nouraei Zeynab , Azimi Maryam , Moghadasi Abdorreza Naser , Tavassolifar Mohammad Javad , Moradi Batool , Sahraian Mohammad Ali , Izad Maryam 
Published: December 2020

AbstractMultiple sclerosis (MS) is a central nervous system (CNS) degenerative disorder which is caused by a targeted autoimmune‐mediated attack on myelin proteins. Previously, mesenchymal stem cells were considered as a novel and successful treatment of MS. One of the underlying mechanisms behind their immunomodulatory function is the release of extracellular vesicles, particularly exosomes. In this study, we aimed to evaluate the suppressive efficacy of MSCs and their exosomes on the proliferation of peripheral mononuclear blood cells (PBMC) in relapsing‐remitting MS (RRMS) patients and healthy subjects. To do, mesenchymal stem cells were derived from human umbilical cord tissues and used for exosome isolation through ultracentrifugation. Suppressive function of MSCs and MSC‐derived exosomes was examined in a coculture with CFSE‐labelled PBMCs in vitro. PBMC proliferation of the patients and healthy individuals was measured using flow cytometry. We first demonstrated that proliferation of PBMCs decreased in the presence of MSCs and suppression was more efficient by MSC‐derived exosomes, with a minimum alloreaction rate. However, suppression capacity of MSCs and their exosomes significantly decreased during extensive sub‐culturing. The present study showed that MSC‐derived exosomes as an effective cell‐free therapy could prevent proliferation of PBMCs. However, further evaluations are need to move towards a functional approach that can be translated to the clinic.
Organising Alternative Food Networks (AFNs): Challenges and Facilitating Conditions of different AFN types in three EU countries
Authors: Poças Ribeiro Ana , Harmsen Robert , Feola Giuseppe , Rosales Carréon Jesús , Worrell Ernst 
Published: December 2020

AbstractThis study aimed to explore the constraining and facilitating factors impacting the emergence and consolidation of different types of alternative food networks (AFNs) in different countries. Drawing on the expertise of organizers of seventeen AFNs, we investigated the conditions and actors that hinder and promote the development of different types of AFNs in Poland, Portugal and the Netherlands. Using a multi‐actor perspective framework, we categorized six types of AFNs according to their logic and characteristics: consumer‐led, producer‐led, third‐sector led, community supported agriculture, public‐led, and business platforms. Key challenges and facilitating conditions varied according to AFN type, and depended on AFN particularities. In contrast to the Netherlands, low social capital was commonly cited as a challenge in Portugal and Poland. AFN organizers appeared to exercise innovative power when creating new forms of food provision; however, a wide scope of actions by governmental and non‐governmental actors are needed to support the emergence of more AFNs.
Feminisation in Agriculture in a Transition Economy: Women’s Role in Family Farms
Authors: Zhllima Edvin , Xhoxhi Orjon , Imami Drini 
Published: December 2020

AbstractResearch on gender equality for several decades has observed gender roles as related to decisions, asset availability, and bargaining power. Literature examining the influence of intra‐family bargaining power and rights on farm structures is scarce. This article builds on the feminisation thesis for exploring how feminisation in agriculture has been changing women’s agency in family farms. It analyses the effect of farming decision‐making in farm structures in Albania, a post‐communist transition country undergoing rural depopulation and migration. Based on data collected from structured farm surveys, an instrumental variable regression is used for exploring the relationship between women’s farming decision power and production structures. The analysis finds a positive influence of women’s decision‐making power on farms oriented to orchards, and a negative influence on farms oriented to forage (livestock‐oriented farms) and farms with uncultivated (abandoned) land. Women’s farming decision‐making power is highly influenced by their education, perception of land rights equality, and access to advisory services. The article provides evidence for interventions including institutional support to strengthen land rights, empowering women farmers through training, awareness campaigns, and advocacy activities.
Manufacturing capital utilisation, firm dynamics and wage inequality
Authors: Chao Chi‐Chur , Hu May , Nguyen Xuan 
Published: December 2020

AbstractThis paper examines the short‐ and long‐run effects of manufacturing capital utilisation on income distribution and social welfare of an economy. A rise in manufacturing capital utilisation lowers the effective cost of capital. This increases the demand for capital in the urban sector, which raises firm output and profitability but reduces the availability of capital in the rural sector. Unskilled wage is lowered. Thus, a rise in manufacturing capital utilisation increases income inequality in the short run. In the long run, due to the firm‐entry effect, a rise in manufacturing capital utilisation further exacerbates the inequality situation. Empirical analysis confirms the theoretical findings. In particular, a one per cent increase in manufacturing capital utilisation leads to about 0.58% increase in income inequality, of which the contribution from the firm‐entry effect is about 28%.
Mechanism evaluation for an amino acid substitution p.Y246C of B‐glycosyltransferase enzyme with Bweak phenotype
Authors: Ying Yanling , Hong Xiaozhen , Xu Xianguo , Zhang Jingjing , He Ji , Zhu Faming , Xie Xinyou 
Published: December 2020

AbstractBackgroundThe amino acid substitutions caused by ABO gene variants are usually predicted to impact the glycosyltransferase function. Here, the effect of an amino acid substitution in the vicinity of the catalytic active region of the B‐glycosyltransferase was explored in vitro and in silico study, which is important for further recognizing the ABO subgroup.MethodsThe ABO serological tests were performed by the routine methods. The ABO genotype was analyzed by polymerase chain reaction and sequenced bidirectionally. The haplotype of the variant allele was separated using single‐strand amplification and sequencing with allele‐specific primers. Stably expression cell lines with variant were constructed for study in vitro. 3D structure of the B‐glycosyltransferase (GTB) variant was simulated by PyMOL software. The free energy change (ΔΔG) was calculated by FoldX.ResultsA variant c.737A > G was identified in a Chinese individual with Bweak phenotype, which led to an amino acid substitution p.Y246C in the vicinity of the catalytic active region of GTB enzyme. The stably expression cell lines with variant and wild type were successfully established and showed that the variant caused a decrease in protein levels and/or enzyme activity. The 3D structural of the GTB modelling found the amino acid substitution p.Y246C caused the hydrogen bond of the protein changes. Meanwhile, the free energy change (ΔΔG) value predicted the destabilizing effect on the variant GTB.DiscussionThe p.Y246C variant in the vicinity of the enzyme active centre reduced the antigen expression because of greatly destabilizing effect on the GTB variant.
The immune potential of ex vivo stored platelets: a review
Authors: Wood Ben , Padula Matthew P. , Marks Denese C. , Johnson Lacey 
Published: December 2020

AbstractPlatelets are now acknowledged as key regulators of the immune system, as they are capable of mediating inflammation, leucocyte recruitment and activation. This activity is facilitated through platelet activation, which induces significant changes in the surface receptor profile and triggers the release of a range of soluble biological response modifiers (BRMs). In the field of transfusion medicine, the immune function of platelets has gained considerable attention as this may be linked to the development of adverse transfusion reactions. Further, component manufacturing and storage methodologies may impact the immunoregulatory role of platelets, and an understanding of this impact is crucial and should be considered alongside their haemostatic characteristics. This review highlights the key interactions between platelets and traditional immune modulators. Further, the potential impact of current and novel component storage methodologies, such as refrigeration and cryopreservation, on this functional capacity is examined, highlighting why further knowledge in this area would be of benefit.
Variability in tumor margin reporting for soft tissue sarcoma and cutaneous mast cell tumors in dogs: A systematic review
Authors: Abrams Brittany E. , Putterman Allison B. , Ruple Audrey , Wavreille Vincent , Selmic Laura E. 
Published: December 2020

AbstractObjectiveTo identify which classification systems have been used for tumor margin reporting and to determine whether factors (publication year, tumor type, and specialty of the contributing authors) influenced trends in margin reporting within literature describing canine soft tissue sarcoma (STS) and cutaneous mast cell tumors (MCT).Study designSystematic literature review.MethodsEligible articles were identified through electronic database searches performed for STS and MCT. Data abstracted from relevant studies included publication year, author list, specialty of contributing authors, criteria used to report the planned surgical margins, and the status of histologic margins. Categorization of papers was based on the classification systems used to report surgical and histologic tumor margins.ResultsFifty‐three articles were included, 11 on STS, 37 on MCT, and five that included both tumor types. Criteria for classifying the planned surgical margins were described in only 50.9% of studies. Articles that listed a veterinary surgeon as a contributing author (P =.01) and STS articles compared to MCT papers (P =.01) were more likely to report surgical margins. Most (56.6%) studies reported the status of histologic margins dichotomously as “complete” or “incomplete.” Although a previously published consensus statement recommended that quantitative criteria be used to report histologic margins, only 7.5% of articles used quantitative methods.ConclusionClassification systems used for reporting tumor margins were highly variable among studies.Clinical significanceThe findings of this review provide evidence that a standardized classification system for reporting surgical and histologic tumor margins is required in veterinary medicine. A universal system may support more consistent reporting of neoplastic biopsy specimens and allow for more meaningful comparisons across research studies.