bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliable Rolling‐guided Point Normal Filtering for Surface Texture Removal
Authors: Sun Y. , Chen H. , Qin J. , Li H. , Wei M. , Zong H. 
Published: November 2019

AbstractSemantic surface decomposition (SSD) facilitates various geometry processing and product re‐design tasks. Filter‐based techniques are meaningful and widely used to achieve the SSD, which however often leads to surface either under‐fitting or over‐fitting. In this paper, we propose a reliable rolling‐guided point normal filtering method to decompose textures from a captured point cloud surface. Our method is built on the geometry assumption that 3D surfaces are comprised of an underlying shape (US) and a variety of bump ups and downs (BUDs) on the US. We have three core contributions. First, by considering the BUDs as surface textures, we present a RANSAC‐based sub‐neighborhood detection scheme to distinguish the US and the textures. Second, to better preserve the US (especially the prominent structures), we introduce a patch shift scheme to estimate the guidance normal for feeding the rolling‐guided filter. Third, we formulate a new position updating scheme to alleviate the common uneven distribution of points. Both visual and numerical experiments demonstrate that our method is comparable to state‐of‐the‐art methods in terms of the robustness of texture removal and the effectiveness of the underlying shape preservation.
No impact on the incidence rate of adenoidectomy 1998‐2014 on a national level in Denmark by the use of nasal steroid and the introduction of pneumococcal vaccines
Authors: Grønlund Casper , Howitz Michael Frantz , Djurhuus Bjarki Ditlev 
Published: November 2019

AbstractObjectiveTo describe trends in incidence rates of adenoidectomy in children in Denmark from 1998‐2014 and to look for possible explanatory factors such as intranasal steroids and pneumococcal vaccination.DesignA nationwide, population‐based, retrospective, interrupted time‐series analysis, using data from Danish registries.SettingHospitals and private Ear, Nose and Throat clinics.ParticipantsChildren who underwent adenoidectomy from 1998 to 2014 in Denmark.Main outcome measureAdenoidectomy.MethodsThe National Patient Register and the National Health insurance Service Register were used to identify all adenoidectomies performed in children. The National Prescription Register supplied data on intranasal steroids.ResultsA total of 174,557 adenoidectomies were identified, distributed among 153 022 children. The annual incidence rate was stable at around 11 per 1000 person‐years from 1998 to 2004. A decrease was seen from 2004 reaching 7.9 in 2009, followed by an increase to 9.1 in 2014. The highest age‐specific incidence rates were seen at 2‐3 years of age. An estimated 14% of children born in 2014 will have had adenoidectomy performed before turning 16 years old. The proportion of adenoidectomies performed in private clinics compared with hospitals was 90%.ConclusionFrom 1998 to 2004 the incidence rate of adenoidectomy in children in Denmark was among the highest in the world with around 11 per 1000 person‐years. A decrease to 7.9 was seen from 2004 to 2009. We found no inverse correlation on a national level between the incidence rates of adenoidectomy and intranasal steroid, nor the introduction of the pneumococcal vaccine. The amount of intranasal steroids used in children in Denmark was negligible compared with adenoidectomy.
Pharmacokinetic and pharmacodynamic bioequivalence of proposed biosimilar MYL‐1501D with US and European insulin glargine formulations in patients with type 1 diabetes mellitus
Authors: Heise Tim , Donnelly Charles , Barve Abhijit , Aubonnet Patrick 
Published: November 2019

AbstractAimsTo report phase 1 bioequivalence results comparing MYL‐1501D, US reference insulin glargine (US IG), and European reference insulin glargine (EU IG).Materials and methodsThe double‐blind, randomized, three‐way crossover study compared the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of MYL‐1501D, US IG and EU IG. In total, 114 patients with type 1 diabetes (T1DM) received 0.4 U/kg of each study treatment under automated euglycaemic clamp conditions. Insulin metabolite M1 concentrations, insulin glargine (IG) and glucose infusion rates (GIRs) were assessed over 30 hours. Primary PK endpoints were area under the serum IG concentration–time curve from 0 to 30 hours (AUCins.0–30h) and maximum serum IG concentration (Cins.max). Primary PD endpoints were area under the GIR–time curve from 0 to 30 hours (AUCGIR0–30h) and maximum GIR (GIRmax).ResultsBioequivalence among MYL‐1501D, US IG and EU IG was demonstrated for the primary PK and PD endpoints. Least squares mean ratios were close to 1, and 90% confidence intervals were within 0.80 to 1.25. The PD GIR–time profiles were nearly superimposable. There were no noticeable differences in the safety profiles of the three treatments, and no serious adverse events were reported.ConclusionsEquivalence with regard to PK and PD characteristics was shown among MYL‐1501D, US IG and EU IG in patients with T1DM, and each treatment was well tolerated and safe.
Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder
Authors: Gersel Stokholm M. , Iranzo A. , Østergaard K. , Serradell M. , Otto M. , Bacher Svendsen K. , Garrido A. , Vilas D. , Fedorova T.D. , Santamaria J. , Møller A. , Gaig C. , Hiraoka K. , Brooks D.J. , Okamura N. , Borghammer P. , Tolosa E. , Pavese N. 
Published: November 2019

Background and purposeCholinergic dysfunction appears to play a role in the cognitive impairment observed in Parkinson’s disease and dementia with Lewy bodies. The occurrence of cholinergic dysfunction in the early stages of these conditions, however, has not been investigated. The objective of this study was to investigate cholinergic function in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD), a disorder recognized to be an early stage of both Parkinson’s disease and dementia with Lewy bodies.MethodsA total of 21 patients with polysomnography‐confirmed iRBD with no evidence of parkinsonism and cognitive impairment and 10 controls underwent positron emission tomography (PET) to assess brain acetylcholinesterase levels (11C‐donepezil PET) and nigrostriatal dopaminergic function (18F‐DOPA PET). Clinical examination included the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale part III, Mini Mental State Examination and Montreal Cognitive Assessment.ResultsThe 11C‐donepezil PET was successfully performed in 17 patients with iRBD and nine controls. Compared with controls, patients with iRBD showed a mean 7.65% reduction in neocortical 11C‐donepezil levels (P = 0.005). Bilateral superior temporal cortex, occipital cortex, cingulate cortex and dorsolateral prefrontal cortex showed the most significant reductions at voxel level.ConclusionReduced neocortical 11C‐donepezil binding in our patients indicates cholinergic denervation and suggests that the projections from the nucleus basalis of Meynert, which supplies cholinergic innervation to the neocortex, are dysfunctional in iRBD. Longitudinal studies will clarify if these changes are predictive of future cognitive impairment in these patients.
Integrating collaborative research in marine science: Recommendations from an evaluation of evolving science‐industry partnerships in Dutch demersal fisheries
Authors: Steins Nathalie A. , Kraan Marloes L. , van der Reijden Karin J. , Quirijns Floor J. , van Broekhoven Wouter , Poos Jan Jaap 
Published: November 2019

AbstractThe increasingly complex nature of marine resource management calls for stronger stakeholder participation in advancing knowledge and developing management approaches. Studies on stakeholder involvement in marine resource management have primarily focussed on participation in resource use negotiation and not on participation in science. Using fishers' knowledge research frameworks, we evaluate over 15 years of science‐industry research collaboration (SIRC) in Dutch demersal fisheries. Four key lessons emerge: (a) Capacity building in SIRC works multiple ways and triggers shifts in the fishers' knowledge research spectrum; (b) Successful SIRC depends on acceptance of industry collected data for scientific advice, which necessitates close involvement of end‐users from the outset to provide feedback and obtain support; (c) (Fisher) participation raises often‐overlooked equity questions and may result in selection bias; and (d) The governance context strongly influences structure of SIRC and integration of SIRC knowledge. To ensure a sustainable, continuous process of stakeholder participation and use of their knowledge in marine resources research, collaborative research should be embedded in the institutional frameworks for science and management. It demands continuous maintenance of the relationship between scientists and stakeholders in the context of management developments, calls for reflection about selection and equity considerations, and requires continuous attention for communication with all parties involved at different levels. The lessons learnt in science‐industry research collaboration in fisheries are also relevant for the wider field of marine science, where stakeholder participation is necessary but not yet common.
Caulobacter crescentus β sliding clamp employs a noncanonical regulatory model of DNA replication
Authors: Jiang Xuguang , Zhang Linjuan , An Jiancheng , Wang Mingxing , Teng Maikun , Guo Qiong , Li Xu 
Published: November 2019

The eubacterial β sliding clamp (DnaN) plays a crucial role in DNA metabolism through direct interactions with DNA, polymerases, and a variety of protein factors. A canonical protein–DnaN interaction has been identified in Escherichia coli and some other species, during which protein partners are tethered into the conserved canonical hydrophobic crevice of DnaN via the consensus β‐binding motif. Caulobacter crescentus is an excellent research model for use in the investigation of DNA replication and cell‐cycle regulation due to its unique asymmetric cell division pattern with restricted replication initiation; however, little is known about the specific features of C. crescentus DnaN (CcDnaN). Here, we report a significant divergence in the association of CcDnaN with proteins based on docking analysis and crystal structures that show that the β‐binding motifs of its protein partners bind a novel pocket instead of the canonical site. Pull‐down and isothermal titration calorimetry results revealed that mutations within the novel pocket disrupt protein–CcDnaN interactions. It was also shown by replication and regulatory inactivation of DnaA assays that mediation of protein interaction by the novel pocket is closely related to the performance of CcDnaN during replication and the DnaN‐mediated regulation process. Moreover, assessments of clamp competition showed that DNA does not compete with protein partners when binding to the novel pocket. Overall, our structural and biochemical analyses provide strong evidence that CcDnaN employs a noncanonical protein association pattern.
Overview of the geometrical influence on the fatigue strength of steel butt welds by a nonlocal approach
Authors: Livieri Paolo , Tovo Roberto 
Published: November 2019

AbstractThe paper deals with the high‐cycle fatigue behaviour of steel butt‐welded joints in the as‐welded condition, under constant amplitude loading. It tackles the problem of strength assessment by changing the geometrical shape and features of the weldment. This investigation considers the recommendations available in design standards, particularly referring to the Eurocodes, and it re‐analyses experimental data where a clear profile of the actual weld shape is available. For the available weld profiles, numerical investigations are shown by applying the Implicit Gradient approach for the evaluation of the nonlocal effective stress in the fatigue strength assessment. The results are very promising since the nonlocal approach significantly agrees with design standard recommendations in conventional cases, but it is also able to provide specific indications on the influence of the geometrical features, as well as the tip radius and opening angles, specifying their influence when no explicitly detailed indications are available in the design standards.
A Revisited Purification of Li for ‘Na Breakthrough’ and its Isotopic Determination by MC‐ICP‐MS
Authors: Xu Lin , Luo Chongguang , Wen Hanjie 
Published: November 2019

The accurate and precise determination of Li isotopic composition by MC‐ICP‐MS suffers from the poor performance of traditional column chromatography. Previously established chromatographic processes cannot completely remove Na in complex geological samples, which is currently interpreted to be a result of Na breakthrough. In this study, Na breakthrough during single‐column purification was found to differ between simply artificial Na‐containing sample solutions, where a little Na residue was found, and silicate rocks, where a large amount of breakthrough occurred. A revised two‐step column purification for Li using 0.5 and 0.3 mol l−1 HCl as eluents was designed to remove the Na. This modified method achieves high‐efficiency Li purification from Na and consequently avoiding high Na/Li ratio interference for subsequent MC‐ICP‐MS analyses. The proposed method was validated by the analysis of a series of reference materials, including Li2CO3 (IRMM‐016, ‐0.10‰), basalt (BCR‐2: 2.68‰; BHVO‐2: 4.39‰), andesite (AGV‐2: 6.46‰; RGM‐2: 2.59‰), granodiorite (GSP‐2: −0.87‰) and seawater (CASS‐5, 30.88‰). This work reports early Na appearance prior to the elution curves in chromatography and emphasises its influence for subsequent Li isotope measurement. Based on the findings, the established two‐step method would be more secure than single‐column chemistry for Li purification.
Achieving the unimaginable: Health equity in haemophilia
Authors: Skinner Mark W. , Nugent Diane , Wilton Pam , O’Mahony Brian , Dolan Gerry , O’Hara Jamie , Berntorp Erik 
Published: November 2019

AbstractHistorically, treatment based on the availability of clotting factor replacement has resulted in an arcane guideline for the correction of factor deficiencies in people with haemophilia (PwH). While all other disease entities seek to restore function to a normal level, PwH are restricted to factor nadirs still equivalent to mild or moderate disease, resulting in continued risk of bleeding. A new treatment paradigm is needed based on the defined needs of PwH. A treatment model was developed by a panel of haemophilia providers, patient advocates and health economists to establish specific treatment milestones and targeted outcomes. The panel defined a series of treatment milestones to characterize the activity and outcomes linked to level of factor deficiency correction. All agreed that the ultimate goal should be ‘functional cure’ and ‘health equity’. Seven levels to achieving a functional cure were identified, (a) Sustain life; (b) Minimal joint impairment; (c) Freedom from any spontaneous bleeds; (d) Attainment of ‘normal’ mobility; (e) Able to sustain minor trauma without additional intervention; (f) Ability to sustain major surgery or trauma; and (g) Normal haemostasis. A parallel set of patient‐reported outcomes to achieve health equity was identified. These guidelines are now comparable with other disorders where the goal is to replace missing proteins to attain normal activity levels. As we are no longer limited by plasma supply due to the manufacture of recombinant factors, mimetics, and the early success of gene therapy, health equity is now achievable.
Distraction‐focused interventions on examination stress in nursing students: Effects on psychological stress and biomarker levels. A randomized controlled trial
Authors: Gebhart Verena , Buchberger Waltraud , Klotz Isabella , Neururer Sabrina , Rungg Christine , Tucek Gerhard , Zenzmaier Christoph , Perkhofer Susanne 
Published: November 2019

AbstractBackgroundNursing students all over the world experience high levels of stress with negative impacts on their health, emotional state and performance.AimThis study aimed to investigate the effects of distraction‐focused interventions on examination stress and anxiety in nursing students.MethodsA randomized controlled, parallel trial design was conducted from January to June 2016. After baseline measurement, 72 participants were randomized to one of the following groups (n = 18 each): (i) animal‐assisted therapy; (ii) music therapy; (iii) mandala painting; (iv) control group. Outcomes of all groups in terms of stress‐reduction were compared by measuring self‐reported perceived stress (STAI‐State and visual analogue stress scale) and salivary biomarker levels (Cortisol and Immunoglobulin A).ResultsFifty‐seven complete data sets (n = 12‐16 for each group) were analysed. All distraction‐focused interventions showed stress and anxiety reduction in everyday school situations. By contrast, on days with examinations, stress reductions did not reach statistical significance in regard to self‐reported psychological stress. At the same time, interventions resulted in significantly decreased levels of stress biomarkers (P < .001).ConclusionsOur preliminary findings suggest positive but situation‐dependent effects of distraction‐focused interventions in academic settings. Further research should investigate the complex relationship between physiological and psychological stress parameters.
Quote dynamics of cross‐listed stocks
Authors: Frijns Bart , Indriawan Ivan , Tourani‐Rad Alireza 
Published: November 2019

AbstractWe develop a model to assess the quote dynamics of stocks listed in multiple markets. This model allows us to explain the price formation mechanism and the degree of information spillover. We show that this model can be transformed to assess the dynamics of the spreads, the efficient price, and the market's relative premium for cross‐listed stocks. Applying our model to a sample of 64 Canadian companies listed in the United States and Canada, we document strong intermarket competition among liquidity providers; prices mainly adjust to trades in their respective market, suggesting some degree of informational frictions; and U.S. trades have a greater price impact than Canadian trades. We further find that the U.S. market is informationally dominant due to its more competitive quote‐setting behavior and larger incorporation of informational shocks.
Electrophysiological features and radiofrequency catheter ablation of accessory pathways associated with atrioventricular discordance
Authors: Takeuchi Daiji , Toyohara Keiko , Shoda Morio , Hagiwara Nobuhisa 
Published: November 2019

AbstractIntroductionAlthough a high prevalence of the presence of an accessory pathway (AP) associated with atrioventricular (AV) discordance has been reported, a case series of its characteristics and the results of catheter ablation (CA) have not been sufficiently documented.Methods and ResultsWe retrospectively examined 11 consecutive patients with atrioventricular discordance who underwent CA for atrioventricular reciprocating tachycardia (AVRT) via an AP and planned cardiac surgery after CA. Orthodromic AVRTs were induced in 10 patients via AP, but no antidromic/duodromic AVRT was induced in any of the cases. A total of 13 APs were identified, and all of them were located around the anatomical tricuspid valve (TV) annulus, including two Ebsteinoid valves. The APs were predominantly located posteriorly, posterolaterally, and posteroseptally on the TV in nine patients (82%). Two patients (18%) had multiple APs or a single broad AP. Four (36%) and three (27%) patients showed twin AVNs and other supraventricular tachycardias (SVTs) except AVRT via the AP. Ten patients (91%) had acute successful CA in the first session, except for one patient with multiple APs who required the third session to eliminate all APs before the planned Fontan surgery. There were no major complications associated with CA. Seven of eight patients who underwent cardiac surgery after CA did not experience peri‐/postoperative SVT.ConclusionAPs in patients with AV discordance are usually associated with the anatomical TV annulus. CA of an AP in AV discordance is highly effective and recommended to reduce the risk of SVT. The coexistence of twin AVNs and other SVTs should be considered during CA of an AP in AV discordance.
Impact of routine right parasternal electrocardiographic screening in assessing eligibility for subcutaneous implantable cardioverter‐defibrillator
Authors: Arias Miguel A. , Pachón Marta , Sánchez‐Iglesias Iván , Loughlin Gerard , Martín‐Sierra Cristina , Puchol Alberto , Sabatel Fernando , Rodríguez‐Padial Luis 
Published: November 2019

AbstractIntroductionBetween 7% and 15% of patients with an indication for an implantable cardioverter‐defibrillator (ICD) are not eligible for implantation of a subcutaneous implantable cardioverter‐defibrillator (S‐ICD) on the basis of the result of the conventional left parasternal electrocardiographic screening (LPES). Our objective was to determine the impact of systematically performing right parasternal electrocardiographic screening (RPES) in addition to conventional LPES, in terms of increasing both the total percentage of potentially eligible patients for S‐ICD implantation and the number of suitable vectors per patient.Methods and resultsConsecutive patients from the outpatient device clinic who already had an implanted ICD, and no requirement for pacing were enrolled. Conventional left parasternal electrode position and right parasternal electrode positions were used. The automatic screening tool was used to analyze the recordings. Screenings were performed in the supine and standing positions.Overall, 209 patients were included. The mean age was 63.4 ± 13 years, 59.8% had ischemic heart disease, mean QRS duration was 100 ± 31 ms, and 69.9% had a primary prevention ICD indication. Based on conventional isolated LPES, 12.9% of patients were not eligible for S‐ICD compared with 11.5% based on RPES alone (P = .664). Considering LPES and RPES together, only 7.2% of patients were not eligible for S‐ICD (P < .001). Moreover, the number of patients with more than one suitable vector increased from 66.5% with isolated LPES to 82.3% (23.7% absolute increase [P < .001]).ConclusionAdding an automated RPES to the conventional automated LPES increased patient eligibility for the S‐ICD significantly. Moreover, combined screening increased the number of suitable vectors per eligible patient.