bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Insights from Old Data: Multimodal Classification of Schizophrenia using Automated Deep Learning Configurations
Authors: Gagana B 
Published: November 2020

AbstractSchizophrenia is a heterogeneous cognitive disorder where clinical classification is challenging because of the lack of well-established, non-invasive diagnoses biomarkers. There is, hence, a need for objective systems that can classify Schizophrenia despite challenges such as overlapping symptomatic factors, diverse internal clinical manifestations, and complex diagnostic process leading to delayed treatment. Thus, experimentation with automated machine learning architectural frameworks (AutoML) is presented in order to handle multimodal Functional Network Connectivity(FNC) and Source Based Morphometry(SBM) features based on functional magnetic resonance imaging(fMRI) and structural magnetic resonance imaging(sMRI) components respectively. On evaluating the resultant AutoML models with respect to approximately 280 machine learning architectures on the Overall AUC metric, the former outperforms the latter despite remarkable limitations including complex high dimensional feature space with very little data.
Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neurons
Authors: Kalmbach Brian E. , Hodge Rebecca D. , Jorstad Nikolas L. , Owen Scott , Bakken Trygve E. , de Frates Rebecca , Yanny Anna Marie , Dalley Rachel , Graybuck Lucas T. , Daigle Tanya L. , Radaelli Cristina , Mallory Matt , McGraw Medea , Dee Nick , Nicovich Philip R. , Keene C. Dirk , Gwinn Ryder P. , Silbergeld Daniel L , Cobbs Charles , Ojemann Jeffrey G , Ko Andrew L , Patel Anoop P , Ellenbogen Richard G. , Sorensen Staci A. , Smith Kimberly , Zeng Hongkui , Tasic Bosiljka , Koch Christof , Lein Ed S. , Ting Jonathan T. 
Published: November 2020

AbstractIn the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The highly distinctive morpho-electric properties of these neurons have mainly been described in rodents, where ET neurons can be labeled by retrograde tracers or transgenic lines. Similar labeling strategies are not possible in the human neocortex, rendering the translational relevance of findings in rodents unclear. We leveraged the recent discovery of a transcriptomically-defined L5 ET neuron type to study the properties of human L5 ET neurons in neocortical brain slices derived from neurosurgeries. Patch-seq recordings, where transcriptome, physiology and morphology are assayed from the same cell, revealed many conserved morpho-electric properties of human and rodent L5 ET neurons. Divergent properties were also apparent but were often smaller than differences between cell types within these two species. These data suggest a conserved function of L5 ET neurons in the neocortical hierarchy, but also highlight marked phenotypic divergence possibly related to functional specialization of human neocortex.
Multiplexed Detection of Sepsis Markers in Whole Blood using Nanocomposite Coated Electrochemical Sensors
Authors: Zupančič Uroš , Jolly Pawan , Estrela Pedro , Moschou Despina , Ingber Donald E. 
Published: November 2020

ABSTRACTSepsis is a leading cause of mortality worldwide that is difficult to diagnose and manage because this requires simultaneous analysis of multiple biomarkers. Electrochemical detection methods could potentially provide a way to accurately quantify multiple sepsis biomarkers in a multiplexed manner as they have very low limits of detection and require minimal sensor instrumentation; however, affinity-based electrochemical sensors are usually hampered by biological fouling. Here we describe development of an electrochemical detection platform that enables detection of multiple sepsis biomarkers simultaneously by incorporating a recently developed nanocomposite coating composed of crosslinked bovine serum albumin containing a network of reduced graphene oxide nanoparticles that prevents biofouling. Using nanocomposite coated planar gold electrodes, we constructed a procalcitonin sensor and demonstrated sensitive PCT detection in undiluted serum and clinical samples, as well as excellent correlation with a conventional ELISA (adjusted r2 = 0.95). Sensors for two additional sepsis biomarkers — C-reactive protein and pathogen-associated molecular patterns — were developed on the same multiplexed platform and tested in whole blood. Due to the excellent antifouling properties of the nanocomposite coating, all three sensors exhibited specific responses within the clinically significant range without any cross-reactivity in the same channel with low sample volume. This platform enables sensitive simultaneous electrochemical detection of multiple analytes in human whole blood, which can be expanded further to any target analyte with an appropriate antibody pair or capturing probe, and thus, may offer a potentially valuable tool for development of clinical point-of-care diagnostics.GRAPHICAL ABSTRACT
Space-Time Covid-19 Bayesian SIR modeling in South Carolina
Authors: Lawson Andrew B , Kim Joanne 
Published: November 2020

AbstractThe Covid-19 pandemic has spread across the world since the beginning of 2020. Many regions have experienced its effects. The state of South Carolina in the USA has seen cases since early March 2020 and a primary peak in early April 2020. A lockdown was imposed on April 6th but lifting of restrictions started on April 24th. The daily case and death data as reported by NCHS (deaths) via the New York Times GitHUB repository have been analyzed and approaches to modeling of the data are presented. Prediction is also considered and the role of asymptomatic transmission is assessed as a latent unobserved effect. Two different time periods are examined and one step prediction is provided.
Rapid development of SARS-CoV-2 receptor binding domain-conjugated nanoparticle vaccine candidate
Authors: Kang Yin-Feng , Sun Cong , Zhuang Zhen , Yuan Run-Yu , Zheng Qing-Bing , Li Jiang-Ping , Zhou Ping-Ping , Chen Xin-Chun , Zhang Xiao , Yu Xiao-Hui , Kong Xiang-Wei , Zhu Qian-Ying , Xu Miao , Zhong Nan-Shan , Zeng Yi-Xin , Feng Guo-Kai , Ke Chang-Wen , Zhao Jin-Cun , Zeng Mu-Sheng 
Published: November 2020

AbstractThe ongoing of coronavirus disease 2019 (COVID-19) pandemic caused by novel SARS-CoV-2 coronavirus, resulting in economic losses and seriously threating the human health in worldwide, highlighting the urgent need of a stabilized, easily produced and effective preventive vaccine. The SARS-COV-2 spike protein receptor binding region (RBD) plays an important role in the process of viral binding receptor angiotensin-converting enzyme 2 (ACE2) and membrane fusion, making it an ideal target for vaccine development. In this study, we designed three different RBD-conjugated nanoparticles vaccine candidates, RBD-Ferritin (24-mer), RBD-mi3 (60-mer) and RBD-I53-50 (120-mer), with the application of covalent bond linking by SpyTag-SpyCatcher system. It was demonstrated that the neutralizing capability of sera from mice immunized with three RBD-conjugated nanoparticles adjuvanted with AddaVax or Sigma Systerm Adjuvant (SAS) after each immunization was ~8-to 120-fold greater than monomeric RBD group in SARS-CoV-2 pseudovirus and authentic virus neutralization assay. Most importantly, sera from RBD-conjugated NPs groups more efficiently blocked the binding of RBD to ACE2 or neutralizing antibody in vitro, a further proof of promising immunization effect. Besides, high physical stability and flexibility in assembly consolidated the benefit for rapid scale-up production of vaccine. These results supported that our designed SARS-CoV-2 RBD-conjugated nanoparticle was competitive vaccine candidate and the carrier nanoparticles could be adopted as universal platform for future vaccine development.
ASCL1 drives induction of a transitory cell state required for repair of the injured neonatal brain
Authors: Bayin N. Sumru , Mizrak Dogukan , Stephen Daniel N. , Lao Zhimin , Sims Peter A. , Joyner Alexandra L. 
Published: November 2020

SummaryThe underlying molecular foundation of neural progenitor diversity and plasticity is critical for understanding repair processes. The neonatal cerebellum with multiple progenitor populations has high regenerative potential. Upon ablation of cerebellar granule cell progenitors at birth, a normally gliogenic Nestin-expressing progenitor (NEP) in the Bergmann glia (Bg) layer (BgL-NEPs) undergoes adaptive reprograming to restore granule neuron production while a white matter NEP (WM-NEPs) reduces interneuron production. However, the cellular states and genes regulating the NEP fate switch are not known. Here using scRNA-seq and fate-mapping, we defined the molecular subtypes of NEPs and their lineages under homeostasis and repair. Five NEP populations comprising two molecular subtypes,Hopx-expressing gliogenic- andAscl1-expressing neurogenic-NEPs were identified in both states. Furthermore, in the WM, distinct NEP populations generate interneurons or astrocytes, and amongst gliogenic-NEPs, astrocyte and Bg lineages are molecularly separable. Importantly, we uncovered that after injury a new transitory cellular state arises fromHopx-NEPs in the BgL that is defined by initiation of expression of the neurogenic geneAscl1. Moreover,Ascl1is required for adaptive reprogramming and the full regenerative capacity of the cerebellum. We thus define new populations of NEPs and identifed the transcription factor responsible for inducing a transitory cell critical for a glial to neural switchin vivofollowing injury.
Involvement of c-Jun N-terminus kinase 2 (JNK2) in Endothelin-1 (ET-1) mediated neurodegeneration of retinal ganglion cells
Authors: Kodati Bindu , Stankowska Dorota L. , Krishnamoorthy Vignesh R. , Krishnamoorthy Raghu R. 
Published: November 2020

AbstractPurposeThe goal of this study was to determine if JNK2 plays a causative role in endothelin-mediated loss of RGCs in mice.MethodsJNK2-/-and wild type (C57BL/6) mice were intravitreally injected in one eye with 1 nmole of ET-1, while the contralateral eye was injected with the vehicle. At two time points (2 h and 24 h) following the intravitreal injections, retinal sections were obtained and phosphorylated c-Jun was assessed. In a separate set of experiments, JNK2-/-and wild type mice were intravitreally injected with either 1 nmole of ET-1 or its vehicle, and euthanized 7 days post-injection. Retinal flat mounts were stained with antibodies to the RGC marker, Brn3a, and surviving RGCs were quantified. Axonal degeneration was assessed by imaging PPD stained optic nerve sections.ResultsIntravitreal ET-1 administration produced a significant increase in immunostaining for phospho c-Jun in wild type mice, which was appreciably lower in the JNK2-/-mice. A significant (p<0.05) 26% loss of RGCs was found in wild type mice, 7 days post injection with ET-1. JNK2-/-mice showed a significant (p=0.36) protection from RGC loss following ET-1 administration, compared to wild type mice injected with ET-1. A significant decrease in axonal counts and an increase in the collapsed axons was found in ET-1 injected mice eyes.ConclusionJNK2 appears to play a major role in ET-1 mediated loss of RGCs in mice. Neuroprotective effects of JNK2 following ET-1 administration occur mainly in the soma and not in the axons of RGCs.
Exploring the programmability of management accounting work for increasing automation: an interventionist case study
Authors: Korhonen Tuomas , Selos Erno , Laine Teemu , Suomala Petri 
Published: November 2020

PurposeThe purpose of this paper is to better understand management accounting automation by exploring the programmability of management accounting work.Design/methodology/approachWe build upon the literature on digitalization in management accounting and draw upon the pragmatic constructivist methodology to understand how digitalization takes place at the individual actors' level in accounting practice. The paper uses a data set from an interventionist case study of a machinery manufacturer.FindingsWe examine an actual process of automating management accounting tasks. During this development process, surprisingly, calculation tasks remained more fit for humans than machines though, initially, they were thought to be programmable.Research limitations/implicationsAccording to our findings, practitioners may interpret experts' nonprogrammable work tasks as programmable and seek to automate them. Only identifying the factual possibilities for automating accounting-related work can lead to automation-improved efficiency. Our findings can be increasingly relevant for advanced analytics initiatives and applications within management accounting (e.g. robotic process automation, big data, machine learning and artificial intelligence).Practical implicationsPractitioners need to carefully analyze the entity they wish to automate and understand the factual possibilities of using and maintaining the planned automatic system throughout its life cycle.Originality/valueThe paper shows that when processes are assessed from a distance, the nonprogrammable management accounting tasks and expertise can become misinterpreted as programmable, and the goal of automating them has little chance of success. It also shows possibilities for human accountants to remain relevant in comparison to machines and paves the way for further studies on advanced decision technologies in management accounting.
Selecting suitable procurement system for steel building construction
Authors: Perera G.P.P.S. , Tennakoon T.M.M.P. , Kulatunga Udayangani , Jayasena Himal Suranga , Wijewickrama M.K.C.S. 
Published: November 2020

PurposeThe purpose of this paper is to select a suitable procurement method for steel building construction in Sri Lanka following a systematic method which weigh, both procurement selection factors and existing procurement systems.Design/methodology/approachAn abductive research stance is followed in this empirical study. Procurement selection factors were selected through a critical literature review which was followed by a quantitative questionnaire survey. The collected data were analysed using descriptive statistical analysis and relative important index.FindingsThe critical literature review outlined 46 procurement selection factors, out of which 26 factors were very important in steel building procurement selection. Short construction period and higher constructability of design are ranked at the top with the highest priority rating factors. Management-oriented procurement system was selected as the most appropriate procurement system for steel building constructions within the Sri Lankan context.Research limitations/implicationsThe study is limited to widely use three procurement systems in Sri Lankan construction industry. Yet, the process followed in selecting the most appropriate procurement system could be applied for other contexts. The implications of the study are mainly identifying management-oriented procurement as the most suitable procurement method for steel building construction in Sri Lanka.Practical implicationsThe systematic procedure of procurement method selection for steel building construction may use in the Sri Lankan construction industry to limit the resource loss due to wrong selection of procurement.Originality/valueA study which critically and comprehensively presenting a procurement selection process for steel building construction is not recorded in Sri Lanka prior to this study.
Trust-based cooperation in Silk Road Economic Belt countries: strategical ordering in the assembly supply chain
Authors: Pu Xujin , Yue Zhenxing , Chen Qiuyan , Wang Hongfeng , Han Guanghua 
Published: November 2020

PurposeThis paper's purpose is to suggest that manufacturers strategically place soft orders for assembly materials with suppliers in Silk Road Economic Belt countries who probably doubt the realization of the soft orders placed.Design/methodology/approachFirst, a two-stage Stackelberg competition is constructed, taking into account the supplier's trust level in formulating the decision process in the assembly supply chain. The authors then provide a buyback contract to coordinate the supply chain, in which the manufacturer obtains enough supplies by sharing some of the perceived risks of not fully trusted suppliers. Furthermore, the authors conduct a numerical study to investigate the influence of trust under a decentralized case and a buyback contract.FindingsThe authors found that all supply chain partners in Silk Road Economic Belt countries experience potential losses due to not fully trusting certain conditions. The study also shows that, in Silk Road Economic Belt countries, operating under a buyback contract is better than being without one in terms of assembly supply chain performance.Research limitations/implicationsOn the one hand, the authors only consider the asymmetry of demand information without considering that of cost structure information. On the other hand, a natural extension of the paper is to integrate single-period transactions into the multi-period transaction problem setting. As all these issues require substantial effort, the authors reserve them for future exploration.Originality/valueDoing business with not-fully-trustworthy partners in Silk Road Economic Belt countries is risky, and this study reveals how trust works in global cooperation and with strategic reactions in situations of partial trust.
Sexual risk behaviours and HIV knowledge and beliefs of Shan migrants from Myanmar living with HIV in Chiang Mai, Thailand
Authors: Jirattikorn Amporn , Tangmunkongvorakul Arunrat , Musumari Patou Masika , Ayuttacorn Arratee , Srithanaviboonchai Kriengkrai , Banwell Cathy , Kelly Matthew 
Published: November 2020

Purpose
For decades, northern Thailand has been a hub for migration in the Greater Mekong Sub-region, particularly for migrants from Myanmar. HIV prevalence among Myanmar/Burmese migrants is higher than in the general Thai population. This study aims to focus on Shan migrants living with HIV in Chiang Mai, the metropolitan centre of northern Thailand and to examine two related aspects: migrants’ sexual risk behaviour and their HIV knowledge and beliefs. The study aims to understand circumstances in which mobility increases HIV risk behaviour and prevalence.

Design/methodology/approach
Using a qualitative study, the authors conducted in-depth interviews in 2017 with 43 HIV-infected Shan migrants (21 males and 22 females), and 29 health-care providers who work in district hospitals in Chiang Mai.

Findings
The authors found that social and economic vulnerability associated with migration, and AIDS-related mortality, increased migrants’ likelihood of having multiple serial partners. Confusion about HIV symptoms, stigmatization of HIV positive women and low risk perceptions, particularly among men, increased their risk behaviours.

Originality/value
To the best of the authors’ knowledge, this paper is the first to study the way of life, sexual behaviour and HIV knowledge and beliefs of Shan Migrants from Myanmar Living with HIV in Thailand.
Solidarity and social behaviour: how did this help communities to manage COVID-19 pandemic?
Authors: Igwe Paul Agu , Ochinanwata Chinedu , Ochinanwata Nonso , Adeyeye Jonathan Olufemi , Ikpor Isaac Monday , Nwakpu Sanita Ekwutosi , Egbo Obiamaka P. , Onyishi Ike E. , Vincent Olusegun , Nwekpa Kenneth Chukwuma , Nwakpu Kingsley Onuoha , Adeoye Ayodeji Adeyinka , Odika Precious Onyinyechi , Fakah Henrietta , Ogunnaike Olaleke Oluseye , Umemezia Evelyn Iyose 
Published: November 2020

PurposeDuring the coronavirus (COVID-19) pandemic lockdowns, stay at home or work from home, many have argued that the westernised non-pharmaceutical interventions (NPI) do not provide remedial in low-income countries like Nigeria, where informal job seekers, street traders, informal labourers and artisans depend mainly on the informal economy. By applying social solidarity (SS) and community-based approach (CBA), the authors evaluate individual acts (trust, altruism and reciprocity) during the lockdown and how these practices evolve from individual approaches to collective actions.Design/methodology/approachThis study reflects on pragmatism research paradigm that enables researchers to maintain both subjectivity in their reflections and objectivity in data collection and analysis. The authors adopt a qualitative method through purposeful and convenience sampling procedure. Data were analysed thematically to identify elements of SS, individual acts, collective or community actions and perceptions.FindingsThe findings reveal that COVID-19 had a disproportionate impact (lack of food and a fall in daily income) on workers, informal job seekers, informal businesses operators and the poor households. As such, the study developed a reflective model of solidarity exhibited by individual acts and collective acts (practices of resource pooling, information sharing, women empowerment, distribution of palliatives and donations) within trusted circles that helped people cope with the lockdown experiences.Practical implicationsSolidarity represents beliefs, practices of values and norms. The SS exhibited by people through NPI would have implications on planning and monitoring the effectiveness of public health programmes during a pandemic in the future.Social implicationsThe findings of citizens and community actions have implications related to the process of building communities – coming together – and solidarity that enhances social development with implications on community health policy agenda during disasters, emergencies and health pandemic.Originality/valueThis is one of the first studies to analyse the relationship between trust, altruism, reciprocity, SS and CBA during the COVID-19 pandemic. Also, it seems reasonable to clarify the concept of SS given the lack of clarity about the definitions from previous studies.
Community attachment and emotional well-being: an empirical study of an online community for people with diabetes
Authors: Wu Philip Fei , Bernardi Roberta 
Published: November 2020

PurposeThe purpose of this study is to investigate how community attachment to an OHC reduces the OHC users' emotional distress and therefore improves their emotional well-being.Design/methodology/approachA survey study was conducted in one of the largest online health communities (OHC) for people with diabetes.FindingsOHC participants are likely to experience reduced emotional distress when they have developed an attachment to the community. This attachment is, in turn, positively associated with the normative expectations of reciprocity and the affective feeling of gratitude. However, some commonly used behavioral measures of community participation, such as visit frequency and membership tenure, have little to do with either community attachment or reduced emotional distress.Research limitations/implicationsThe research highlights the pivotal role of community attachment in appraising the much-debated benefits of OHCs. However, the cross-sectional survey study has its limitations in terms of establishing causality.Practical implicationsOHC managers need to look beyond some of the commonly used metrics, such as monthly visits and number of new postings, and focus on fostering a sense of attachment among existing users in order to fulfill the OHC's potential of emotional support. Our study implies that design features facilitating reciprocation and gratitude expression among users can lead to a strong emotional bond.Originality/valueThis is one of the first studies on the antecedents of community attachment and the relationship between community attachment and emotional distress in the context of OHC.