bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results Multi-Laboratory Trial ISO/CD 22184—IDF/WD 244: Milk and Milk Products—Determination of the Sugar Contents—High-Performance Anion Exchange Chromatography Method with Pulsed Amperometric Detection
Authors: Brunt Kommer , Sanders Peter , Ernste-Nota Veronica , van Soest J. 
Published: July 2020

Abstract

Background
In this international Multi-Laboratory Trial (MLT) the precision data and the accuracy of the ISO/CD 22184 IDF/WD 244 analytical method for the quantification of 6 different mono- and disaccharides (galactose, glucose, fructose, sucrose, lactose, and maltose) in milk and milk products with high-performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) are established.

Objective
Thirteen different laboratories participated (located in New Zealand, the United States, and Europe). The study was divided into two parts. First, the learning/familiarization part in which the participants got experienced with the method. After successfully completing this part, the participants were allowed to continue with the second part of this trial: the analyses of the seven blind MLT duplicate samples.

Method
The selected seven MLT samples comprise five MUVA reference dairy samples, one NIST-certified infant formula and one industrial sample. In the Tables S-1 to S-6 the results of this MLT study have been summarized per sugar. There is a very good agreement between the MUVA and NIST-certified sugar contents in the MLT samples and in the MLT established sugar contents in those MUVA and NIST samples.

Results
This demonstrates that the accuracy of the newly developed HPAEC-PAD method is very good.

Conclusions
Certificates of analysis were available for both the MUVA samples and the NIST sample. There is a very good agreement between the by MUVA- and NIS-certified sugar contents in the MLT samples and the corresponding in the MLT established sugar contents. This demonstrates that the accuracy of the HPAEC-PAD method is very good. In the IDF/ISO Analytical Week in June 2019 in Prague the report on the MLT study were discussed and adopted.
Acute abdomen due to spilled gallstones: a diagnostic dilemma 10 years after laparoscopic cholecystectomy
Authors: Kafadar Mehmet Tolga , Çetinkaya İsmail , Aday Ulaş , Başol Ömer , Bilge Hüseyin 
Published: July 2020

Abstract
Laparoscopic cholecystectomy (LC) carries a significant risk of gallbladder perforation and resulting scattering of bile stones into the abdominal cavity. The retrieval of the spilled stones is not always possible by laparoscopic technique. Most cases do not create long-term problems, although some cases may be complicated in future and create uncertainties regarding the correct diagnosis. Diagnosis can be difficult, and in most cases the patient may require open surgery for management of these complications. Herein, we report a case of acute abdomen due to spilled stones occurring 10 years after LC. In the first stage, definitive diagnosis could not be made with computed tomography examination. Finally, the patient was diagnosed with explorative laparotomy.
The complex large-scale magnetic fields in the first Galactic quadrant as revealed by the Faraday depth profile disparity
Authors: Ma Y K , Mao S A , Ordog A , Brown J C 
Published: July 2020

ABSTRACT
The Milky Way is one of the very few spiral galaxies known to host large-scale magnetic field reversals. The existence of the field reversal in the first Galactic quadrant near the Sagittarius spiral arm has been well established, yet poorly characterized due to the insufficient number of reliable Faraday depths (FDs) from extragalactic radio sources (EGSs) through this reversal region. We have therefore performed broad-band (1–$2\, {\rm GHz}$) spectropolarimetric observations with the Karl G. Jansky Very Large Array (VLA) to determine the FD values of 194 EGSs in the Galactic longitude range of 20°–52° within ±5° from the Galactic mid-plane, covering the Sagittarius arm tangent. This factor of five increase in the EGS FD density has led to the discovery of a disparity in FD values across the Galactic mid-plane in the Galactic longitude range of 40°–52°. Combined with existing pulsar FD measurements, we suggest that the Sagittarius arm can host an odd-parity disc field. We further compared our newly derived EGS FDs with the predictions of three major Galactic magnetic field models, and concluded that none of them can adequately reproduce our observational results. This has led to our development of new, improved models of the Milky Way disc magnetic field that will serve as an important step towards major future improvements in Galactic magnetic field models.
Restoring the night sky darkness at Observatorio del Teide: First application of the model Illumina version 2
Authors: Aubé Martin , Simoneau Alexandre , Muñoz-Tuñón Casiana , Díaz-Castro Javier , Serra-Ricart Miquel 
Published: July 2020

ABSTRACT
The propagation of artificial light into real environments is complex. To perform its numerical modelling with accuracy, one must consider hyperspectral properties of the lighting devices and their geographic positions, the hyperspectral properties of the ground reflectance, the size and distribution of small-scale obstacles, the blocking effect of topography, the lamps angular photometry and the atmospheric transfer function (aerosols and molecules). A detailed radiative transfer model can be used to evaluate how a particular change in the lighting infrastructure may affect the sky radiance. In this paper, we use the new version (v2) of the Illumina model to evaluate a night sky restoration plan for the Teide Observatory located on the island of Tenerife, Spain. In the past decades, the sky darkness was severely degraded by growing light pollution on the Tenerife Island. In this work, we use the contribution maps giving the effect of each pixel of the territory to the artificial sky radiance. We exploit the hyperspectral capabilities of Illumina v2 and show how the contribution maps can be integrated over regions or municipalities according to the Johnson–Cousins photometric bands spectral sensitivities. The sky brightness reductions per municipality after a complete shutdown and a conversion to light-emitting diodes are calculated in the Johnson–Cousins B, V, R bands. We found that the conversion of the lighting infrastructure of Tenerife with LED (1800 and 2700 K), according to the conversion strategy in force, would result in a zenith V-band sky brightness reduction of ≈0.3 mag arcsec−2.
The last breath of the Sagittarius dSph
Authors: Vasiliev Eugene , Belokurov Vasily 
Published: July 2020

ABSTRACTWe use the astrometric and photometric data from Gaia Data Release 2 and line-of-sight velocities from various other surveys to study the 3D structure and kinematics of the Sagittarius dwarf galaxy. The combination of photometric and astrometric data makes it possible to obtain a very clean separation of Sgr member stars from the Milky Way foreground; our final catalogue contains 2.6 × 105 candidate members with magnitudes G &lt; 18, more than half of them being red clump stars. We construct and analyse maps of the mean proper motion and its dispersion over the region ∼30 × 12 deg, which show a number of interesting features. The intrinsic 3D density distribution (orientation, thickness) is strongly constrained by kinematics; we find that the remnant is a prolate structure with the major axis pointing at ∼45° from the orbital velocity and extending up to ∼5 kpc, where it transitions into the stream. We perform a large suite of N-body simulations of a disrupting Sgr galaxy as it orbits the Milky Way over the past 2.5 Gyr, which are tailored to reproduce the observed properties of the remnant (not the stream). The richness of available constraints means that only a narrow range of parameters produce a final state consistent with observations. The total mass of the remnant is $\sim \!4\times 10^8\, \mathrm{M}_\odot$, of which roughly a quarter resides in stars. The galaxy is significantly out of equilibrium, and even its central density is below the limit required to withstand tidal forces. We conclude that the Sgr galaxy will likely be disrupted over the next Gyr.
Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense
Authors: Makarova Kira S , Timinskas Albertas , Wolf Yuri I , Gussow Ayal B , Siksnys Virginijus , Venclovas Česlovas , Koonin Eugene V 
Published: July 2020

Abstract
CRISPR-associated Rossmann Fold (CARF) and SMODS-associated and fused to various effector domains (SAVED) are key components of cyclic oligonucleotide-based antiphage signaling systems (CBASS) that sense cyclic oligonucleotides and transmit the signal to an effector inducing cell dormancy or death. Most of the CARFs are components of a CBASS built into type III CRISPR–Cas systems, where the CARF domain binds cyclic oligoA (cOA) synthesized by Cas10 polymerase-cyclase and allosterically activates the effector, typically a promiscuous ribonuclease. Additionally, this signaling pathway includes a ring nuclease, often also a CARF domain (either the sensor itself or a specialized enzyme) that cleaves cOA and mitigates dormancy or death induction. We present a comprehensive census of CARF and SAVED domains in bacteria and archaea, and their sequence- and structure-based classification. There are 10 major families of CARF domains and multiple smaller groups that differ in structural features, association with distinct effectors, and presence or absence of the ring nuclease activity. By comparative genome analysis, we predict specific functions of CARF and SAVED domains and partition the CARF domains into those with both sensor and ring nuclease functions, and sensor-only ones. Several families of ring nucleases functionally associated with sensor-only CARF domains are also predicted.
Thoracic Paravertebral Blockade Reduces Chronic Postsurgical Pain in Breast Cancer Patients: A Randomized Controlled Trial
Authors: Lin Zeng-Mao , Li Mu-Han , Zhang Feng , Li Xue , Shao Chun-Li , Li Xue-Ying , Wang Dong-Xin 
Published: July 2020

Abstract

Objective
To evaluate the effect of multilevel single-shot thoracic paravertebral blockade (PVB) on the occurrence of chronic postsurgical pain (CPSP) in patients undergoing breast cancer surgery.

Design
A randomized controlled trial with two parallel groups.

Setting
A tertiary hospital.

Methods
Patients scheduled for breast cancer surgery were randomized to receive either ultrasound-guided multilevel single-shot PVB from T2 to T5 (the PVB group) or nothing (the control group). Surgery was then performed under general anesthesia. Patients were followed up for 12 months after surgery. The primary end point was incidence of CPSP at six months after surgery.

Results
A total of 218 patients were enrolled and randomized; of these, 208 and 204 completed six- and 12-month follow-up, respectively. The incidence of CPSP at six months was significantly lower in the PVB group (12.5% [13/104]) than in the control group (24.0% [25/104], relative risk = 0.52, 95% CI = 0.28–0.96, P = 0.031). Pain scores within 48 hours both at rest and with movement were lower in the PVB group than the control group (P = 0.006 and P &lt; 0.001, respectively). The percentages of patients with neuropathic pain were also lower in the PVB group than the control group at both six and 12 months after surgery (P = 0.016 and 0.028, respectively). Adverse events did not differ between groups.

Conclusions
For patients undergoing breast cancer surgery, multilevel single-shot PVB reduces the incidence of CPSP at six months; it also improves early postoperative analgesia and reduces neuropathic pain at six and 12 months after surgery.
Does it Matter if Respondents Look up Answers to Political Knowledge Questions?
Authors: Style Hillary , Jerit Jennifer 
Published: July 2020

Abstract
Using novel instrumentation from a large national sample, this research note examines respondents who look up answers to factual knowledge questions. Consistent with past work linking outside search to a self-enhancing response style, we show that people who research the answers to knowledge questions also self-report higher levels of political engagement. Moreover, validated vote data indicate that higher self-reports of registration status and turnout are overreports of the actual behaviors. Finally, we analyze the characteristics of people who engage in outside search and explore whether simple warnings are effective at reducing this behavior.
Current algebra formulation of quantum gravity and its application to cosmology
Authors: Funai Shotaro Shiba , Sugawara Hirotaka 
Published: July 2020

Abstract
Gravity theory based on current algebra is formulated. The gauge principle rather than general covariance combined with the equivalence principle plays a pivotal role in the formalism, and the latter principles are derived as a consequence of the theory. In this approach, it turns out that gauging the Poincaré algebra is not appropriate but gauging the $SO(N,M)$ algebra gives a consistent theory. This makes it possible to have anti-de Sitter and de Sitter space-time by adopting a relation between the spin connection and the tetrad field. The Einstein equation is part of our basic equation for gravity, which is written in terms of the spin connection. When this formalism is applied to the $E(11)$ algebra in which the three-form antisymmetric tensor is part of a gravity multiplet, we have a current algebra gravity theory based on M-theory in the sense that the internal group or the connection space representations of our model are those appearing in 11D supergravity. Moreover, when our formalism in its classical limit is applied to cosmology, by introducing conformal-like modes that connect the tetrad field/current and the spin connection field/current, we can obtain an accelerating universe in the manner of the “inflating” universe at its early stage.
Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness
Authors: Muto Vincenzo , Koshmanova Ekaterina , Ghaemmaghami Pouya , Jaspar Mathieu , Meyer Christelle , Elansary Mahmoud , Van Egroo Maxime , Chylinski Daphne , Berthomier Christian , Brandewinder Marie , Mouraux Charlotte , Schmidt Christina , Hammad Grégory , Coppieters Wouter , Ahariz Naima , Degueldre Christian , Luxen André , Salmon Eric , Phillips Christophe , Archer Simon N , Yengo Loic , Byrne Enda , Collette Fabienne , Georges Michel , Dijk Derk-Jan , Maquet Pierre , Visscher Peter M , Vandewalle Gilles 
Published: July 2020

Abstract

Study Objectives
Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset.

Methods
We computed whole-genome PRS for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation, and extended sleep opportunity, in a carefully selected homogenous sample of 363 healthy young men (22.1 years ± 2.7) devoid of sleep and cognitive disorders.

Results
AD PRS was associated with more slow-wave energy, that is, the cumulated power in the 0.5–4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with larger slow-wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness.

Conclusions
These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and support the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.
An opisthorchiid concept of the genusLiliatrema(Trematoda: Plagiorchiida: Opisthorchioidea): an unexpected systematic position
Authors: Sokolov Sergey , Frolov Evgeniy , Novokreshchennykh Semen , Atopkin Dmitry 
Published: July 2020

AbstractLiliatrema is a small genus of trematodes consisting of two species. Its systematic position has long been debated, partly because of the confusing reports about the structure of male terminal genitalia. Here we test the phylogenetic position of the genus Liliatrema using data on complete 18S rRNA and partial 28S rRNA gene sequences obtained for Liliatrema skrjabini. We also provide a detailed description of terminal genitalia in adult specimens of L. sobolevi and metacercariae of both Liliatrema species. The results of the 28S rDNA-based phylogenetic analysis indicate that Liliatrema falls within a well-supported clade, which also includes Apophallus and traditional opisthorchiids. This clade, in turn, is nested within a well-supported clade, containing Euryhelmis, Cryptocotyle and Scaphanocephalus. In the 18S+8S rDNA analysis, Liliatrema appears as a sister-taxon to the Cryptocotyle + Euryhelmis group. The Liliatrema + (Cryptocotyle + Euryhelmis) clade is a well-supported sister-group to the traditional opisthorchiids. The morphology of the terminal genitalia of the liliatrematids also corresponds to that of the opisthorchioids. Thus, the results of our morphological and phylogenetic analyses favour an unexpected conclusion that the genus Liliatrema belongs to the Opisthorchioidea. We propose that the genera Liliatrema, Apophallus, Euryhelmis, Cryptocotyle and Scaphanocephalus belong, respectively, within the subfamilies Liliatrematinae, Apophallinae, Euryhelminthinae and Cryptocotylinae of the family Opisthorchiidae.
Trauma-Informed Medical Education (TIME): Advancing Curricular Content and Educational Context
Authors: Brown Taylor , Berman Sarah , McDaniel Katherine , Radford Caitlin , Mehta Pooja , Potter Jennifer , Hirsh David A. 
Published: July 2020

The majority of patients and medical students experience some form of psychological trauma or adversity across their life course. All forms of trauma can be associated with adverse health consequences and can negatively affect learning and professional development. Trauma-informed care (TIC) offers a framework to address and mitigate these consequences and promote safety and health. The Substance Abuse and Mental Health Services Administration describes 6 domains of TIC: safety; trust and transparency; peer support; collaboration and mutuality; empowerment, voice, and choice; and cultural, historic, and gender issues.
At present, TIC is not taught routinely in undergraduate medical education (UME)—a crucial educational gap given that UME grounds the development of key perspectives and practices that students use throughout their careers. Further, given the prevalence of preexisting trauma among learners and the likelihood of new traumatic exposures during training, medical schools’ processes, practices, and learning environments may risk exacerbating or even causing trauma. To address this educational need and support students and their future patients, the authors propose a trauma-informed medical education (TIME) framework.
TIME informs medical schools’ curricular content and educational context. In UME, curricular content should address trauma epidemiology, physiology, and effects; trauma-informed clinical skills including sensitive communication and physical exam techniques; and trauma-informed self-care techniques including education on organizational resources, how to elicit supports, and personal self-care practices. A trauma-informed educational context encompasses curricular development, including student–faculty coproduction of educational content; curricular delivery, including faculty development on TIC principles; and learning environment, including trauma-informed educational practices, medical student advising, institutional policies, and recruitment. TIME offers practical strategies to support teaching, learning, educational administration, and professional development and aims to inspire new strategies for effective learner and faculty engagement. TIME aims to foster students’ development of competency in TIC and promote student engagement, learning, health, and well-being.
Body Habitus and Dynamic Surgical Conditions Independently Impair Pulmonary Mechanics during Robotic-assisted Laparoscopic Surgery
Authors: Tharp William G. , Murphy Serena , Breidenstein Max W. , Love Collin , Booms Alisha , Rafferty Melissa N. , Friend Alexander F. , Perrapato Scott , Ahern Thomas P. , Dixon Anne E. , Bates Jason H. T. , Bender S. Patrick 
Published: July 2020

Background
Body habitus, pneumoperitoneum, and Trendelenburg positioning may each independently impair lung mechanics during robotic laparoscopic surgery. This study hypothesized that increasing body mass index is associated with more mechanical strain and alveolar collapse, and these impairments are exacerbated by pneumoperitoneum and Trendelenburg positioning.

Methods
This cross-sectional study measured respiratory flow, airway pressures, and esophageal pressures in 91 subjects with body mass index ranging from 18.3 to 60.6 kg/m2. Pulmonary mechanics were quantified at four stages: (1) supine and level after intubation, (2) with pneumoperitoneum, (3) in Trendelenburg docked with the surgical robot, and (4) level without pneumoperitoneum. Subjects were stratified into five body mass index categories (less than 25, 25 to 29.9, 30 to 34.9, 35 to 39.9, and 40 or higher), and respiratory mechanics were compared over surgical stages using generalized estimating equations. The optimal positive end-expiratory pressure settings needed to achieve positive end-expiratory transpulmonary pressures were calculated.

Results
At baseline, transpulmonary driving pressures increased in each body mass index category (1.9 ± 0.5 cm H2O; mean difference ± SD; P < 0.006), and subjects with a body mass index of 40 or higher had decreased mean end-expiratory transpulmonary pressures compared with those with body mass index of less than 25 (–7.5 ± 6.3 vs. –1.3 ± 3.4 cm H2O; P < 0.001). Pneumoperitoneum and Trendelenburg each further elevated transpulmonary driving pressures (2.8 ± 0.7 and 4.7 ± 1.0 cm H2O, respectively; P < 0.001) and depressed end-expiratory transpulmonary pressures (–3.4 ± 1.3 and –4.5 ± 1.5 cm H2O, respectively; P < 0.001) compared with baseline. Optimal positive end-expiratory pressure was greater than set positive end-expiratory pressure in 79% of subjects at baseline, 88% with pneumoperitoneum, 95% in Trendelenburg, and ranged from 0 to 36.6 cm H2O depending on body mass index and surgical stage.

Conclusions
Increasing body mass index induces significant alterations in lung mechanics during robotic laparoscopic surgery, but there is a wide range in the degree of impairment. Positive end-expiratory pressure settings may need individualization based on body mass index and surgical conditions.

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