bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are Saudi adults supportive of Saudi Food &amp; Drug Authority’s food policies? Assessment of public support &amp; awareness for Saudi Food &amp; Drug Authority’s food policies
Authors: Tami Suzan , Al-Mahish Mohammed 
Published: June 2020

Abstract
Background

Numerous countries, including Saudi Arabia, are considering nutrition and food policies to help control the obesity epidemic and other non-communicable diseases. The present study examined public support and awareness, among Saudi adults, for the Saudi Food and Drugs Authority’s (SFDA) food policies, specifically whether public support and awareness for SFDA policies and regulations have a significant impact on their average Body Mass Index (BMI), and how socio-economic variables impact the public support and awareness for SFDA policies and regulations.
Methods

In this cross-sectional study, 584 Saudi adults completed an electronic questionnaire, collected data on whether the public were aware and supportive of SFDA’s different food polices and regulations. To examine whether participants’ awareness and support of SFDA’s food policies had a significant impact on their average BMI, two sample t-test was used, and a logistic regression model was used to examine the impact of demographics variables on participants’ support and awareness for SFDA policies and regulations.
Results

Saudi adults followed SFDA’s latest news and regulations and were supportive of SFDA’s food policies. Particularly, high support was for food policies of requiring restaurants and coffee shops to report calorie amounts in foods and beverages, reducing the salt amount in bread, eliminate hydrogenated oil from food products, and preventing misleading written nutrition information on food products, and preventing food advertisements without permission. The results of the two-sample t-test showed that there was a significant difference in the mean BMI between the participants who followed and those who did not follow SFDA news and regulations. The mean BMI between the participants who cooperated and those who did not cooperate with SFDA by reporting food safety violations was significantly different. The results of the binary logit model indicated that several socio-demographic characteristics were significantly associated with food policy awareness and support.
Conclusion

The findings of this study may assist nutrition educators to plan programs to improve health-related behaviors, and may allow stakeholders and policy makers to consider public perception and social desirability in the policy-making and implementation process.
Prevalence of depression and associated factors among Chinese military plateau drivers in Golmud, Qinghai Province, China: a cross-sectional study
Authors: Tu Zhi-hao , Peng Li , He Jing-wen , Shen Xing-hua 
Published: June 2020

Abstract
Background: Depression is associated with declining duty performance, suicide and other serious problems in the army. Prolonged deployment at high altitude may result in depression among military personnel. The present study aimed to investigate the prevalence of depression among Chinese military plateau drivers and determine the associated factors.Methods: The participants were military drivers selected from Golmud motor transport base (high altitude group) and Fuzhou motor transport base (low altitude group). All participants were asked to complete a self-administrated questionnaire. The questionnaire included demographic and working characteristics, the Self Rating Depression Scale (SDS), the 14-item Fatigue Scale (FS-14), the Global Assessment of Migraine Severity (GAMS), the numeric rating scale (NRS) for dyspnea, and item three of the Patient Health Questionnaire-9-item (PHQ-9) for screening sleep disturbance.Results: A total of 400 questionnaires were distributed (200 for each group); 400 questionnaires were collected (the response rate was 100%). After eliminating 16 invalid questionnaires, 194 plateau drivers and 190 lowland drivers provided valid response (96.0%). In comparison to lowland drivers, the plateau drivers had severer fatigue (t = 4.298, p < 0.001), severer migraine (t = 11.440, p < 0.001), severer breathlessness (t = 12.094, p < 0.001), severer sleep disturbance (t = 3.353, p = 0.001), and higher prevalence of depression symptoms (χ2 = 15.123, p < 0.001). The possibility of having depression symptoms was significantly higher among military plateau drivers who were suffering severer fatigue (OR = 1.14, 95% CI: 1.01-1.29), migraine (OR = 1.83, 95% CI: 1.13-2.95), breathlessness (OR = 1.69, 95% CI: 1.04-1.73), and sleep disturbance (OR = 1.78, 95% CI: 1.03-3.07).Conclusion: Prevalence of depression was high among Chinese military plateau drivers. The risk factors were fatigue, severity of migraine, severity of breathlessness, and poor sleep quality. It is essential to become aware of these risk factors and their causes to intervene and help prevention of depression among Chinese military plateau drivers.
Cost-effectiveness and cost-utility analysis of a web-based computer-tailored intervention for prevention of binge drinking among Spanish adolescents
Authors: Vargas-Martínez Ana Magdalena , Lima-Serrano Marta , Trapero-Bertran Marta 
Published: June 2020

Abstract
BackgroundWorldwide, binge drinking (BD) today follows being a public health concern among adolescents. This study sought to assess the cost-effectiveness and cost-utility of a web-based computer-tailored intervention to prevent BD in adolescence.MethodsThe sample was drawn from a study evaluating the Alerta Alcohol programme. The population consisted of adolescents aged 15–19. Decision tree analysis was used to estimate costs and health outcomes, as measured by number of BD occasions and quality-adjusted life years (QALYs). Incremental Cost-Effectiveness and Cost-Utility Ratios were also calculated from National Health Service (NHS) and societal perspective and for a time horizon of four months. Multivariate deterministic sensitivity analysis of best/worst scenarios by subgroups was used to account for uncertainty.ResultsThe intervention was dominant from the societal perspective resulting in savings of €7,986.37 by one BD occasion averted per month. With regard to Incremental Cost-Utility Ratios, the intervention resulted in an incremental cost of €71.05 per QALY gained from NHS perspective and this was dominant, from societal perspective, resulting in savings of €34,126.64 per QALY gained in comparison with the control group. Subgroup analyses showed that the intervention resulted dominant for girls from both perspectives, and for those who were older (17 years or more) from NHS perspective.ConclusionComputer-tailored feedback is a cost-effective way to reduce BD and to increase QALYs among adolescents. However, long-term follow-up would probably be needed to capture major changes both in reduction of BD and in increasing of health-related quality of life.Trial registration(ClinicalTrials.gov): NCT03288896. Registration date: September 20, 2017. “Retrospectively registered”.
The transcriptomic and phenotypic response of the melanized yeast Exophiala dermatitidis to ionizing particle exposure
Authors: Schultzhaus Zachary , Chen Amy , Shuryak Igor , Wang Zheng 
Published: June 2020

Abstract
Fungi can tolerate extremely high doses of ionizing radiation compared with most other eukaryotes, a phenomenon encompassing both the recovery from acute exposure and the growth of melanized fungi in chronically contaminated environments. This observation has led to the use of fungi in radiobiology studies, with the goal of finding novel resistance mechanisms that could assist fields such as nuclear medicine and space biology. As photonic (x-ray and γ-ray) exposure is the most widely available method for irradiation, little work has been done examining how fungi (other than budding yeast) respond to irradiation by ionizing particles (e.g. protons), although particle irradiation may cause distinct cellular damage, and it is more relevant to environmental exposure profiles. Here, we expand on a previous study of the melanized yeast Exophiala dermatitidis responding to γ-radiation exposure by characterizing the phenotypic and transcriptomic response to irradiation by three different ionizing particles: protons, deuterons, and α-particles. No significant difference in survival was observed between these strains under any condition, suggesting that melanin does not impart protection to acute irradiation to these particles. The transcriptomic response during recovery to particle exposure was similar to that observed after γ-irradiation, with DNA repair and replication genes upregulated, and genes involved in translation and ribosomal biogenesis being heavily repressed, indicating an attenuation of cell growth. However, a comparison of global gene expression showed clear clustering into particle and γ-radiation groups. The response elicited by particle irradiation was more complex. Compared to the γ-associated response, particle irradiation resulted in greater changes in gene expression, a more diverse set of differentially expressed genes, and a significant induction of gene categories such as autophagy and protein catabolism. Additionally, individual particle responses were analyzed and compared, resulting in the discovery of unique expression signatures and individual genes for each particle type that could be used as radio-nuclide discrimination markers. The strong response we observed here at the gene expression level inprovides insights into the unique types of damage that particle irradiation causes to fungal cells, allowing for future dissection of radiation source-specific resistance mechanisms.
The Relationship Between Musculoskeletal Pains, Serum Estradiol Level and Climacteric Symptoms in Postmenopausal Women
Authors: Mohamadzade Neda , Sadatmahalleh Shahideh Jahanian , Ziaei Saeideh , Zaeemzadeh Narges , Kazemnejad Anoshirvan 
Published: June 2020

Abstract
Background: Due to the decrease of estrogen levels in postmenopausal females, menopause can be associated with musculoskeletal pains. This study was designed to assess the possible association between musculoskeletal pains, serum estradiol level, and climacteric symptoms in postmenopausal women.Methods: This cross-sectional study was conducted on 307 postmenopausal females selected by convenience sampling method. Data collection procedure lasted from October 2016 to September 2018. The required data were collected using the Menopause Rating Scale (MRS), Örebro Musculoskeletal Pain Questionnaire (ÖMPQ), and a questionnaire containing personal data. The blood sample was taken to measure the estradiol level. Results: There was a direct relationship between musculoskeletal pains and menopause symptoms (p<0.001), age (p=0.03), parity (p=0.01), and BMI (p=0.03) and an indirect association between musculoskeletal pain and marriage age (p=0.009), age of first pregnancy (0.017), estradiol level (p<0.001) and education level (p=0.002). The regression analysis results showed that menopause symptoms were the strongest predictor of musculoskeletal pains among all the variables.Conclusions: The findings of the present study showed that although various parameters are associated with musculoskeletal pains, climacteric symptoms are the most important predictive parameters of musculoskeletal pains.
Predicting EQ-5D Index Scores from the PROMIS-29 Profile for the United Kingdom, France, and Germany
Authors: Klapproth Christoph Paul , Bebber Jan van , Gibbons Christopher J. , Valderas Jose M , Alain Leplege , Rose Matthias , Fischer Felix 
Published: June 2020

Abstract
Background: EQ-5D health utility (HU) scores are commonly used in health economics to compute quality-adjusted life years (QALYs). EQ-5D scores, which are country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models for predicting EQ-5D scores from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model.Methods: We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n=1,509), France (n=1,501), and Germany (n=1,502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D score from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D scores in all three countries using various indices for the prediction performance, including Bland-Altman plots to examine the performance along the HU continuum.Results:The EQ-5D index scores were best predicted in Germany (RMSEGER = 0.10, MAEGER = 0.06), followed by France (RMSEFR = 0.11, MAEFR = 0.08) and the UK (RMSEUK = 0.12, MAEUK = 0.09). The Bland-Altman plots show that the inclusion of higher-order effects reduced the underprediction of low HU scores.Conclusions: Our models provide a valid method to predict EQ-5D-5L index scores from the PROMIS-29 for the UK, France, and Germany.
A Case Report of Heparin-Induced Thrombocytopenia in a Patient One Month after Coronary Artery Bypass Graft Surgery in the Era of Coronavirus Disease 2019
Authors: mungan ibrahim , izdeş seval 
Published: June 2020

Abstract
Background : Coronavirus infectious disease 2019 (COVID-19), which evolved to a global pandemic issue leads to coagulation system abnormalities and low molecular heparin or unfractionated heparin is advised. Heparin-induced thrombocytopenia (HIT) is one of the most worried complications of heparin exposure.Case Presentation: In this case report, we presented a 75 year- old male patient with suspicious COVID-19 infection who admitted to our intensive care unit one month after cardiac surgery. On admission due to increased D-dimer level and history of CABG, he was started to LMWH (enoxaparin) 0.5 mg/kg twice daily yet HIT occurred and enoxaparin was held. Fondaparinux was started to decrease the thrombosis risk.Conclusion: In the era of COVID-19, the management of coagulopathy is important while HIT should be mind in every patient after the preliminary heparin treatment.
Cross-national study of worrying, loneliness, and mental health during the COVID-19 pandemic: a comparison between individuals with and without infection in the family
Authors: Bonsaksen Tore , Leung Janni , Schoultz Mariyana , Thygesen Hilde , Price Daicia , Ruffolo Mary , Geirdal Amy Østertun 
Published: June 2020

Abstract

Background
As a response to the COVID-19 pandemic outbreak, strict national policies regarding public behavior were implemented in countries throughout the world, including Europe, America and Australia. Social distancing became the main policy for public behavior, in effect imposing radical changes in people’s everyday life. Thus, mental health may be affected at the general population level and not only among those who have been infected by the disease or have witnessed family members or close ones fall ill.
Methods
A cross-sectional online survey was conducted in Norway, UK, USA and Australia during April/May 2020. Participants (n = 3810) were recruited via social media postings by the researchers and the involved universities. Differences between those with and without infection in the family were investigated with chi-square tests and independent t-tests. Multiple regression analyses were used to assess associations between sociodemographic variables and psychological outcomes (worry, loneliness and mental health) in both groups.
Results
Compared to their counterparts, participants with infection in the family reported higher levels of worries about themselves (p < 0.05) and their family members (p < 0.001), and had poorer mental health (p < 0.05). However, the effect sizes related to the differences were small. The largest effect (d = 0.24) concerned worries about their immediate family. Poorer psychological outcomes were observed in those who were younger, female, unemployed, living alone and had lower levels of edcuation, yet with small effect sizes.
Conclusions
In view of the small differences between those with and without infection, we generally conclude that the mental health effects of the COVID-19 situation are not limited to those who have been infected or have had infection within the family, but extend to the general population.
Knowledge, attitudes, practices, and the effects of COVID-19 on health seeking behaviors among young people in Kenya
Authors: Karijo Evalin , Wamugi Sylvia , Lemanyishoe Samuel , Njuki Jenny , Boit Faith , Kibui Vania , Karanja Sarah , Abuya Timothy 
Published: June 2020

Abstract
Background: The cases of Corona Virus Disease of 2019 (COVID-19) in Kenya have been increasing rapidly, since the first case was confirmed in early March, 2020. In the wake of the crisis around COVID-19, the health and socio-economic challenges experienced by Kenya’s largest demography, the youth, are likely to elevated. This study sought to establish knowledge levels, gaps and attitude of the youth with regards to COVID-19 and identify the effects of the pandemic on health seeking behaviour and socio-economic status of youth.Methods: A cross sectional descriptive study was conducted among 2,153 youth across 47 counties in Kenya, through a combined online survey and phone interviews. All survey responses analyzed using STATA v15 were tabulated by gender, age, education level to generate basic descriptive tables and tested for differences by category using chi-square tests with a significance level of 0.05. Where applicable linear and logistic regression analysis model was conducted with covariates such as employment status, gender and education level were used.Results: Knowledge on symptoms of COVID-19 was generally high. Female respondents were more likely to name more symptoms correctly compared to men; p<0.001. However, youth reported very low levels of anyone being at risk of infection (7%). Since they started receiving messaging on COVID-19, most youth have adopted behavior necessary to slow down the infection. There were generally very low reported levels of inability to access health services related to sexual and reproductive health. About 50% of respondents reported significant decline in income during the pandemic period, while nearly a third reported living in fear while 27% reported feeling stressed.Conclusion: Our study revealed considerably high knowledge of COVID-19 symptoms, preventive strategies and most commonly sources of information that are instructive for the pandemic response. Findings suggest messaging campaigns should focus on reaching clarifying risk groups. The need to track health service use among youth is essential to lay longer term strategies towards minimizing potential long-term consequences of the pandemic. Strategies to sustain behaviors positively adopted and leverage the vast network of youth as champions of behavior change will be critical to reduce the spread of COVID-19.
Retrospective Analysis of Articular Surface Defect Cases Caused by Pathological Fracture of Giant Cell Tumor of Distal Femur Treated With Three-Dimension-Printed Custom-Made Prostheses Versus Conventional Endoprosthesis Replacement: Three-Dimension-Printed Custom-Made Prostheses Have Better Function Outcome
Authors: Ji Yuqing , Wu Yuxian , Yang Qiang , Li Zhenfeng , Li Jianmin 
Published: June 2020

Abstract
Background: Pathological fracture of the distal femur giant cell tumor (GCT) occasionally leads to articular surface defect. The conventional endoprosthesis replacement needs to remove the both condyles, and then the patients probably face lower prosthesis survival rate and multiple joint replacement, especially in young patients. The aims of this study were to evaluate the feasibility of 3D-printed custom-made prosthesis in repairing the articular surface defect at a short-term follow-up.Methods: We retrospectively reviewed fourteen patients admitted and treated from January 2012 to January 2018 with mean age of 43.9 years (range 29 to 69 years). Diagnoses were primary pathological fracture of distal femur giant cell tumor (GCT) which articular surface of one condyle is defect. 10 lesions were located in medial femoral condyle and 16 in Lateral femoral condyle. Twelve patients were treated with three-dimension-printed custom-made prosthesis to repaired of articular surface defect (3D-printed group), and the other Fourteen patients were treated with endoprosthesis replacement (EPR group). Operation time, blood loss was compared between the groups. Functional results were assessed with MSTS score. The range of motion (ROM), local recurrences and complications were statistically compared.Results: Mean Follow-up is 33.5 months (range 26 to 43 months). In the 3D-printed group, operation time and blood loss were significantly less (p < 0.05). Differences in functional outcomes of the MSTS were observed between the two groups from three-month follow-up (p < 0.05) to twenty-four-month follow-up (p < 0.05), and the score were higher in the 3D-printed group than the EPR group. The ROM of the 3D-printed group was statistically better than the EPR group at 6 and 9 months after operation (p < 0.05). Local recurrence and complication rates were similar in the two groups (p = 1).Conclusion: 3D-printed custom-made prosthesis represent a promising reconstructive technique in articular surface defect caused by pathological fracture of GCT of distal femur. It could be able to achieve satisfactory oncological and better short-term functional results compared with endoprosthesis replacement. Further studies are needed to evaluate the stability of the implants and the wear of the articular surface with larger samples at long-term.
WITHDRAWN: Numerical and Experimental Investigation of Deployment Behaviour of Folded Fin Mechanism based on the Dynamic Loading Conditions
Authors: AVCI MURAT , TAGA ÖZER , KELEŞ ÖMER 
Published: June 2020

Abstract
In this study, the friction and damping values ​​that arise during the deployment of the folded fin mechanism were obtained based on the experimental data. Although there are recommended values ​​for friction in the literature, damping is a phenomenon that varies from system to system and must be obtained through test data. In this study, firstly, the mechanism was operated on the test device with a specific drive pressure and the actual drive pressure generated in the system was measured. The dynamic behaviour of the mechanism was recorded by a High-Speed camera system as well. Adams MBD (multi-body dynamics) was used to define the mechanism model and drive pressure data from the test was defined as input to the model. With the help of Adams DOE (Design of Experiments), certain intervals were defined for friction and damping, multiple analyses were carried out at the friction and damping intervals defined and total deployment time of the mechanism and the dynamic behaviours it exhibited during deployment were obtained. From these numerical results obtained, friction and damping values ​​were obtained based on the model with the highest correlation and test results. The same mechanism was tested for different drive pressures with the specified friction and damping values ​​and the results were compared to the numerical models. It was decided that the friction and damping values ​​determined as a result of the comparison could be used in future numerical analyses.