bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the Prevalence of Primary Aldosteronism in Patients With New-Onset Type 2 Diabetes and Hypertension
Authors: Hu Yuhang , Zhang Jingjing , Liu Wei , Su Xin 
Published: March 2020

AbstractContextDespite a high prevalence of hypertension in diabetes and close relationship between primary aldosteronism (PA) and glucose metabolism, few study concerns the prevalence of PA in diabetes with hypertension.ObjectiveThis study aimed to detect the prevalence of PA in patients with new-onset type 2 diabetes (T2D) and hypertension and to explore the association between PA and diabetes.MethodsA total of 256 outpatients with new-onset T2D and hypertension were screened for PA. Plasma aldosterone concentration (PAC), plasma renin activity (PRA) were measured. Patients with an aldosterone renin activity ratio (ARR) ≥ 30 ng/dL/ng/mL/h and PAC ≥ 15 ng/dL underwent confirmatory captopril challenge test (CCT) for PA. The diagnostic criteria for PA were, after CCT, (1) PAC decreased &lt; 30%, (2) ARR maintained ≥ 30 ng/dL/ng/mL/h, and (3) PAC was ≥ 11 ng/dL.ResultsOf 256 consecutive patients, 99 (39%) were positive for the screening test, and 49 (19%) were diagnosed with PA. Compared with those in groups A (screening test −) and B (screening test +, CCT −), patients in group C (diagnosed with PA) had a higher percentage of systolic blood pressure of ≥ 160 mmHg, less family history of hypertension, and lower serum potassium. Patients in group B and C had higher PAC and ARR levels, but lower PRA than those in group A. Homeostatic model assessment for insulin resistance (HOMA-IR) was positively associated with PAC level among the diabetic patients.ConclusionThe prevalence of PA in new-onset T2D patients with hypertension is at least 19%. Higher aldosterone may be related with insulin resistance in patients with diabetes.
The effectiveness of integrating clinical pharmacists within general practice to optimise prescribing and health outcomes in primary care patients with polypharmacy: A protocol for a systematic review
Authors: Croke Aisling , James Oscar , Clyne Barbara , Moriarty Frank , Cardwell Karen , Smith Susan M. 
Published: March 2020

Introduction: Coordinating prescribing for patients with polypharmacy is a challenge for general practitioners. Pharmacists may improve management and outcomes for patients with polypharmacy. This systematic review aims to examine the clinical and cost-effectiveness of pharmacist interventions to optimise prescribing and improve health outcomes in patients with polypharmacy in primary care settings. Methods: The review will be reported using the PRISMA guidelines. A comprehensive search of 10 databases from inception to present, with no language restrictions will be conducted. Studies will be included where they evaluate the clinical or cost-effectiveness of a clinical pharmacist in primary care on potentially inappropriate prescriptions using validated indicators and number of medicines. Secondary outcomes will include health related quality of life measures, health service utilisation, clinical outcomes and data relating to cost effectiveness. Randomised controlled trials, non-randomised controlled trials, controlled before-after, interrupted-time-series and health economic studies will be eligible for inclusion. Titles, abstracts and full texts will be screened for inclusion by two reviewers. Data will be extracted using a standard form. Risk of bias in all included studies will be assessed using the Effective Practice and Organisation of Care (EPOC) criteria. Economic studies will be assessed using the Consensus Health Economic Criteria (CHEC) list as per the Cochrane Handbook for critical appraisal of methodological quality. A narrative synthesis will be performed, and the certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Where data support quantitative synthesis, a meta-analysis will be performed. Discussion: This systematic review will give an overview of the effectiveness of pharmacist interventions to improve prescribing and health outcomes in a vulnerable patient group. This will provide evidence to policy makers on strategies involving clinical pharmacists integrated within general practice, to address issues which arise in polypharmacy and multimorbidity. PROSPERO Registration: CRD42019139679 (28/08/19)
From support worker to district nurse team manager: a narrative
Authors: Donovan Patricia , Hayden Amanda 
Published: March 2020

As the general population ages, so too does the nursing workforce. A recent Queen's Nursing Institute (QNI) report (2019a) stated that 1 in 10 qualified district nurse positions have been lost in the past 10 years—without a trained workforce to replace those who retire. Workforce planning is central to ensure safe and effective care in the community setting. This article aims to provide a narrative account of one student who started her career at the University of Bolton as a trainee assistant practitioner and over time achieved her present position as a district nurse team manager. The account will include her journey from support worker to assistant practitioner, studying at the University of Bolton as a trainee assistant practitioner on a ‘work, earn and learn’ programme. It details the support she received from mentors in the trust, alongside her onward journey to registered nurse and specialist nurse practitioner qualifications.
Effective clinical feedback provision to ambulance clinicians: a literature review
Authors: Eaton-Williams Peter , Mold Freda , Magnusson Carin 
Published: March 2020

BackgroundClinical feedback provision to health professionals is advocated to benefit both clinical development and work engagement.AimThis literature review aims to develop recommendations for effective clinical feedback provision by examining mechanisms that exist specifically for ambulance clinicians.Method:A systematic search of contemporary literature identified 15 research papers and four articles, which were included for review and narrative synthesis.FindingsThe initial identification of practice that requires improvement, together with an understanding of the practitioners' baseline attitudes, is important. While minimising resource demands will improve sustainability, repeated interaction with clinicians will benefit effectiveness. Provision should be balanced and timely, and who delivers feedback is significant. Clinical outcome feedback not restricted to specific conditions requires further consideration of which incidents will initiate feedback and what information will be supplied.ConclusionFeedback has been shown to improve clinical performance but demonstrating subsequent benefits to patient outcomes has proved more difficult.
Restoration Celebrity Culture: Twenty-First-Century Regenderings and Rewritings of Charles II, the Merry Monarch, and his Mistress “Pretty, witty” Nell Gwyn
Authors: Martínez-García Laura 
Published: March 2020

AbstractCharles II was a figure of controversy during his reign and continues to be one of the most iconic and well-known British monarchs; the portrayals of this King vary significantly from one author to the other and from one period to the next, but they invariably focus on his penchant for frivolity and his sexual liaisons. One of his favourite royal mistresses is Nell Gwyn, the oyster girl, turned orange seller, turned actress, turned mother of Dukes. The figure of ‘pretty, witty’ Nelly has fascinated biographers, filmmakers and novelists for centuries due to its Cinderella-like undertones and the natural fascination that the first female performers have exerted on the public imagination. This paper studies modern rewritings of Charles’s and Nell’s affair and of the two lovers themselves, to trace the attitudes towards the King’s illicit affair and towards the actress’s social climbing. The aim of this paper is to question the motivations for these re-imaginings and to help discover the reasons why the monarch and his “Protestant Whore”The name comes, legend has it, from Nell Gwyn herself and is an anecdote that has been recounted innumerable times. Granger explains that “the story [...] is a known fact; as is also that of her being insulted in her coach at Oxford, by the mob, who mistook her for the duchess of Portsmouth. Upon which she looked out of the window, and said, with her usual good humour, Pray, good people, be civil: I am the protestant whore. This laconic speech drew upon her the blessings of the populace, who suffered her to proceed without further molestation” (Granger 2010: 429).have become the focus of such varied re-writings and two of the most prominent characters of the British public imagination, surpassing the boundaries of their professions, to become part of popular culture.
The crystal structure of poly[bis(N,N-dimethylformamide-κ1
O)-tetrakis(μ2-cyanido-κ2
C:N)dinickel(II)], C10H14N6O2Ni2
Authors: Yang Shuang-Hua 
Published: March 2020

Abstract
C10H14N6O2Ni2, monoclinic, I2/m (no. 12), a = 6.7377(1) Å, b = 7.3500(1) Å, c = 14.8647(2) Å, β = 96.051(1)°, V = 732.030(18) Å3, Z = 8, R
gt(F) = 0.0314, wR
ref(F
2) = 0.0996, T = 150.01(10) K.
Quaternary intermetallics RE
2Pt3Ga4In (RE=Y, Gd-Tm) – intergrowth structures of NdRh2Sn4 and TiNiSi related slabs
Authors: Horiacha Myroslava , Reimann Maximilian K. , Kösters Jutta , Zaremba Vasyl‘ I. , Pöttgen Rainer 
Published: March 2020

Abstract
The quaternary gallium-rich intermetallic phases RE
2Pt3Ga4In with RE = Y and Gd-Tm were synthesized by arc-melting of the elements and subsequent annealing. Small single crystals were obtained by high-frequency annealing of the samples in sealed tantalum ampoules. The polycrystalline samples were characterized through their X-ray powder patterns. The RE
2Pt3Ga4In phases crystallize with a site ordering variant of the orthorhombic Y2Rh3Sn5 type, space group Cmc 21. The structures of Gd2Pt3Ga4In, Dy2Pt3Ga4.14In0.86, Er2Pt3Ga4.17In0.83 and Tm2Pt3Ga4.21In0.79 were refined from single-crystal X-ray diffraction data. The single crystals reveal small homogeneity ranges RE
2Pt3Ga4±xIn1±x. The striking geometrical structural building units are slightly distorted trigonal prisms around the three crystallographically independent platinum atoms: Pt1@RE
4Ga2, Pt2@RE
2Ga4 and Pt3@RE
2Ga2In2. Based on these prismatic building units, the RE
2Pt3Ga4In structures can be described as intergrowth variants of TiNiSi and NdRh2Sn4 related structural slabs. Temperature dependent magnetic susceptibility studies of Gd2Pt3Ga4In and Tb2Pt3Ga4In show Curie-Weiss behavior and the experimental magnetic moments confirm stable trivalent gadolinium respectively terbium. Gd2Pt3Ga4In and Tb2Pt3Ga4In order antiferromagnetically at T
N = 15.8(1) and 26.0(1) K. Magnetization curves at 3 K show field-induced spin reorientations.
Composition of the essential oil of
Satureja metastasiantha
: a new species for the flora of Turkey
Authors: Carikci Sema , Goren Ahmet C. , Dirmenci Tuncay , Yalcinkaya Burhanettin , Erkucuk Aysen , Topcu Gulacti 
Published: March 2020

Abstract
The aerial parts of Satureja metastasiantha were hydrodistilled for 3 h using a Clevenger-type apparatus. The essential oils were analyzed by gas chromatography/flame ionization detector and gas chromatography/mass spectrometry, simultaneously, the main compounds of which were characterized as p-cymene (22.3%), thymol (21.0%), carvacrol (18.4%), and γ-terpinene (12.1%). Antioxidant capacity, acetylcholinesterase and butyrylcholinesterase inhibition effects, and antimicrobial and antifungal properties of the species were evaluated. The anticholinesterase activity of the essential oil of S. metastasiantha was observed with 30% inhibition at 200 μg/mL. The essential oil of the species showed activity against Staphylococcus aureus with 128 μg/mL minimum inhibitory concentration value.
DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood inCaenorhabditis elegans
Authors: McHugh Daniel R , Koumis Elena , Jacob Paul , Goldfarb Jennifer , Schlaubitz-Garcia Michelle , Bennani Safae , Regan Paul , Patel Prem , Youngman Matthew J 
Published: March 2020

AbstractAging is accompanied by a progressive decline in immune function termed “immunosenescence”. Deficient surveillance coupled with the impaired function of immune cells compromises host defense in older animals. The dynamic activity of regulatory modules that control immunity appears to underlie age-dependent modifications to the immune system. In the roundworm Caenorhabditis elegans levels of PMK-1 p38 MAP kinase diminish over time, reducing the expression of immune effectors that clear bacterial pathogens. Along with the PMK-1 pathway, innate immunity in C. elegans is regulated by the insulin signaling pathway. Here we asked whether DAF-16, a Forkhead box (FOXO) transcription factor whose activity is inhibited by insulin signaling, plays a role in host defense later in life. While in younger C. elegansDAF-16 is inactive unless stimulated by environmental insults, we found that even in the absence of acute stress the transcriptional activity of DAF-16 increases in an age-dependent manner. Beginning in the reproductive phase of adulthood, DAF-16 upregulates a subset of its transcriptional targets, including genes required to kill ingested microbes. Accordingly, DAF-16 has little to no role in larval immunity, but functions specifically during adulthood to confer resistance to bacterial pathogens. We found that DAF-16-mediated immunity in adults requires SMK-1, a regulatory subunit of the PP4 protein phosphatase complex. Our data suggest that as the function of one branch of the innate immune system of C. elegans (PMK-1) declines over time, DAF-16-mediated immunity ramps up to become the predominant means of protecting adults from infection, thus reconfiguring immunity later in life.
In vitro activity of colistin against multidrug-resistant Acinetobacter baumannii isolates harboring blaOXA-23-like and blaOXA-24-like genes: A multicenter based study
Authors: Khanjani Susan , Sedigh Ebrahim-Saraie Hadi , Shenagari Mohammad , Ashraf Ali , Mojtahedi Ali , Atrkar Roushan Zahra 
Published: March 2020

AbstractThis study was aimed to evaluate occurrence of antibiotic resistance and the presence of resistance determinants among clinical isolates of Acinetobacter baumannii. This cross-sectional study from January to September 2018 was performed on 59 A. baumannii strains isolated from clinical samples in the north of Iran. Isolates were identified by standard microbiologic tests and molecular method. Antimicrobial susceptibility testing was carried out by disk diffusion and broth microdilution methods. The presence of carbapenem resistance genes was detected by PCR method. All isolates were resistant to cefepime, meropenem, imipenem and ceftazidime. The lowest resistance rate was observed against doxycycline with 33.9%. Minimum inhibitory concentration (MIC) results showed that all carbapenem-resistant A. baumannii (CRAB) isolates were susceptible to colistin with MIC50 and MIC90 values of 1/2 µg/mL. Among 59 CRAB, blaOXA-23-like was the most prevalent gene (86.4%) followed by blaOXA-24-like (69.5%). Meanwhile, none of the clinical isolates harbored blaOXA-58-like gene. We found a high prevalence of CRAB strains harboring OXA-type carbapenemases in the north of Iran. Our results suggests that the presence of OXA-type genes was not directly correlated with the increase of imipenem MIC level, but can be clinically important as they contribute to the selection of CRAB strains.
Tigecycline susceptibility of multidrug-resistant Acinetobacter baumannii from intensive care units in the western Balkans
Authors: Gajic Ina , Ranin Lazar , Kekic Dusan , Opavski Natasa , Smitran Aleksandra , Mijac Vera , Jovanovic Snezana , Hadnadjev Mirjana , Travar Maja , Mijovic Gordana 
Published: March 2020

AbstractTigecycline can be effective to treat infections of carbapenem-resistant Acinetobacter baumannii (CRAB) however, no interpretive criteria have been approved so far. The objectives of this study were to evaluate the proportion of CRAB isolates and to compare gradient test with a broth microdilution (BMD) method for tigecycline susceptibility testing of A. baumannii.This study included 349 multidrug-resistant (MDR) Acinetobacter spp. collected from Serbia, Montenegro, Bosnia and Herzegovina in 2016 and 2017. Antibiotic susceptibility testing was performed by disk diffusion, VITEK2, gradient, ComASP Colistin. Tigecycline susceptibilities were interpreted according to breakpoints of European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Food and Drug Administration (FDA).Majority of the tested isolates were CRAB (92.8%). Tigecycline MIC50/MIC90 values were 4/8 μg/mL by BMD and 0.5/4 μg/mL by gradient test. Essential agreement for BMD and gradient test amounted to 65.1%. With EUCAST breakpoints, categorical agreement (CA) was achieved in 38% isolates. Major discordance (MD-false susceptibility/resistance) and minor discordance (mD-false categorization involving intermediate results) were observed in 10% and 57% A. baumannii, respectively. With FDA breakpoints, CA, MD and mD were observed in 44%, 16% and 47% isolates, respectively. Colistin resistance was 2.1%.The study highlights a high proportion of CRAB and several discordances between BMD and gradient test which may lead to inappropriate therapy.
The effect of blood flow restriction and plyometric training methods on dynamic balance of Taekwondo athletes
Authors: Akin Manolya , Kesilmiş İnci 
Published: March 2020

Background and Study Aim. Taekwondo (TKD) is a combat sport emphasizing on kicking techniques and dynamic footwork. Specialized balance ability is crucial for Taekwondo practitioners. Nowadays balance could be improved with specific strength training such as blood flow restriction and plyometric training. Thus, the aim of this study was to understand the effect of blood flow restriction (BFR) and pliometric training methods on the development of dynamic balance at the martial art of Taekwondo.
Material and Methods. Totally 31 TKD athletes between 15-19 ages participated voluntarily and were divided into three groups as blood flow restriction (n=11), plyometric training (n=10) and control groups (n=10). In addition to normal taekwondo training, 8 week training programs were applied to the pliometric and blood flow restriction groups, and no training program was applied to the control group. At the beginning and after the trainings, dynamic balance ability measured with Prokin Tecnobody equipment for 30 seconds slalom test.
Results. The difference between pre-test and post-test values of BFR group’s dynamic balance (antero-posterior sway) was found to be statistically different (p<.05) while according to the pliometric training results, there was no statistically significant difference (p>.05). Also, there was not any difference in terms of gender (p>.05).
Conclusions. Strength development is neccessary for dynamic balance improvement in athletes. Since taekwondo athletes use strength and balance ability for rapid kicking and change direction, these motor abilities are important for success. Based on the findings of this study; it is recommended that BFR method may be useful and so it can be included in training programs.
Membangun Kerukunan Antarumat Beragama berbasis Budaya Lokal Menyama Braya di Denpasar Bali
Authors: Basyir Kunawi 
Published: March 2020

Religious experience of multicultural society in Indonesia has frequently been characterized by conflict and violence in various regions. As a state having the motto Bhinneka Tunggal Ika, Indonesia has several challenges and problems of plurality, ethnicity, religion, and culture. However, each culture has it own local wisdom to overcome these challenges and problems. This article finds that the presence of religious life (Hindu-Muslim) in Denpasar Bali does not look like other regions in Indonesia, which is always covered by conflict and violence in the name of religion. Multicultural society in Denpasar Bali indicates ideal collaboration between Muslims and Hindus to build religious activities. It is an integral part of Balinese life and the Balinese friendly character to sprout back to Bali Glow (Bali Aga). It sure takes a long time to proceed through the dialectical theology, ideology, and socio-cultural processes. Together with social institutions, the local government had tried to maintain and protect the essence of Hindu Balinese culture, by preserving the tradition of Menyama Braya for the realization of harmonious religiosity.
[Pengalaman religius masyarakat multikultural di Indonesia sudah sering ditandai dengan konflik dan kekerasan di berbagai daerah. Sebagai negara yang memiliki motto Bhinneka Tunggal Ika, Indonesia memiliki beberapa tantangan dan masalah pluralitas, etnis, agama, dan budaya. Meskipun demikian, setiap budaya memiliki kearifan lokal yang dapat mengatasi berbagai tantangan dan permasalahan di atas. Artikel ini menemukan bahwa kehadiran kehidupan keagamaan (Hindu-Muslim) di Denpasar Bali tidak terlihat seperti daerah lain di Indonesia, yang selalu ditutupi oleh konflik dan kekerasan atas nama agama. masyarakat multikultural di Denpasar Bali menunjukkan kolaborasi ideal antara Muslim dan Hindu untuk membangun kegiatan keagamaan. Ini adalah bagian integral dari kehidupan Bali dan karakter ramah Bali bertunas kembali ke Bali Cahaya (Bali Aga). Tentu membutuhkan waktu yang lama untuk melanjutkan melalui teologi dialektis, ideologi, dan proses sosial budaya. Bersama dengan lembaga-lembaga sosial, pemerintah setempat telah berusaha untuk mempertahankan dan melindungi esensi dari budaya Hindu Bali, dengan melestarikan tradisi Menyama Braya untuk realisasi religiusitas yang harmonis.
Stereotip Mahasiswa IAIN Pontianak terhadap Agama Baha’i
Authors: Hidayat Samsul 
Published: March 2020

In general, people of West Kalimantan have slight understanding relating to the existence of Baha’i religion. They built some stereotypes and judgments based on interaction and daily communication with Baha’i followers. This research focuses on how the under-graduate student of State Institute of Islamic studies (IAIN) Pontianak perceive and understand Baha’i during the class of Interreligious Communication (Komunikasi Lintas Agama). Dealing with the under-graduate student of the seventh semester, this research aims to analyze such paradigm construction through Thung Ju Lan idea of “foreigners” and “cultural differences”. This research found that students have constructed their perception on Baha’i through theological denial or cultural assessment of other religious tradition.
[Secara umum penduduk Kallimantan Barat memiliki pemahaman yang tidak mendalam terkait dengan agama Baha’i. Mereka membangun prasangka, stereotip, dan keyakinan sendiri tentang Baha’i, berdasar pada interksi dan komunikasi sehari-sehari dengan pemeluk Baha’i. Penelitian ini fokus pada bagaimana mahasiswa Institut Agama Islam Negeri (IAIN) Pontianak membangun pandangan dan pemahaman mereka terhadap Baha’i dalam kelas matakuliah Komunikasi Lintas Agama. Meneliti para mahasiswa yang duduk di semester ke-7, penelitian ini bertujuan untuk menganalisis bagunan kerangka berpikir tersebut melalui konsepnya Thung Ju Lan, foreigners and cultural differences. Penelitian ini menemukan bahwa sebagian mahasiswa membangun persepsi teologis terkait agama Baha’i sebagai “sesuatu yang semestinya ditolak” dan “tidak sesuai dengan agama Islam.]