bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spain: The Evidence Provided by International Large-Scale Assessments About the Spanish Education System: Why Nobody Listens Despite All the Noise
Authors: Gomendio Montse 
Published: November 2020

AbstractILSAs show that student performance in Spain is lower than the OECD average and has shown no progress from 2000 until 2011/2012. One of the main features is the low proportion of top performers. During this long period of stagnation, the education system was characterized by having no national (or standardized regional) evaluations and no flexibility to adapt to the different needs of the student population. The fact that the system was blind and rigid, plus the lack of common standards at the national level, gave rise to three major deficiencies: a high rate of grade repetition, which led to high rates of early school leaving, and large differences between regions. These features of the Spanish education system represent major inequities. However, PISA findings were used to reinforce the misguided view that the Spanish education system prioritized equity over excellence. After the implementation of an education reform, some improvements in student performance took place in 2015 and 2016. Unfortunately, the results for PISA 2018 in reading were withdrawn for Spain, apparently due to changes in methodology which led to unreliable results. To this date, no explanation has been provided raising concerns about the reliability and accountability of PISA.
Failure Mechanisms of Alloys with a Bimodal Graine Size Distribution
Authors: Skripnyak Vladimir A. , Skripnyak Evgeniya G. , Skripnyak Vladimir V. 
Published: November 2020

AbstractA multi-scale computational approach was used for the investigation of a high strain rate deformation and fracture of magnesium and titanium alloys with a bimodal distribution of grain sizes under dynamic loading. The processes of inelastic deformation and damage of titanium alloys were investigated at the mesoscale level by the numerical simulation method. It was shown that localization of plastic deformation under tension at high strain rates depends on grain size distribution. The critical fracture stress of alloys depends on relative volumes of coarse grains in representative volume. Microcracks nucleation at quasi-static and dynamic loading is associated with strain localization in ultra-fine grained partial volumes. Microcracks arise in the vicinity of coarse and ultrafine grains boundaries. It is revealed that the occurrence of a bimodal grain size distributions causes increased ductility, but decreased tensile strength of UFG alloys. The increase in fine precipitation concentration results not only strengthening but also an increase in ductility of UFG alloys with bimodal grain size distribution.
Nanomaterials Interaction with Cell Membranes: Computer Simulation Studies
Authors: Tsukanov Alexey A. , Vasiljeva Olga 
Published: November 2020

AbstractThis chapter provides a brief review of computer simulation studies on the interaction of nanomaterialswith biomembranes. The interest in this area is governed by the variety of possible biomedical applications of nanoparticles and nanomaterials as well as by the importance of understanding their possible cytotoxicity. Molecular dynamics is a flexible and versatile computer simulation tool, which allows us to research the molecular level mechanisms of nanomaterials interaction with cell or bacterial membrane, predicting in silico their behavior and estimating physicochemical properties. In particular, based on the molecular dynamics simulations, a bio-action mechanism of two-dimensional aluminum hydroxide nanostructures, termed aloohene, was discovered by the research team led by Professor S. G. Psakhie, accounting for its anticancer and antimicrobial properties. Here we review three groups of nanomaterials (NMs) based on their structure: nanoparticles (globular, non-elongated), (quasi)one-dimensional NMs (nanotube, nanofiber, nanorod) and two-dimensional NMs (nanosheet, nanolayer, nanocoated substrate). Analysis of the available in silico studies, thus can enable us a better understanding of how the geometry and surface properties of NMs govern the mechanisms of their interaction with cell or bacterial membranes.
The Knowledge Creation and Transfer Mechanism
Authors: Ackers Louise , Ackers-Johnson Gavin , Welsh Joanne , Kibombo Daniel , Opio Samuel 
Published: November 2020

AbstractThis chapter reflects on the relationship between the knowledge mobilisation processes that have contributed to behaviour change at an individual and organisational level. It critiques the traditional emphasis in international development on one-off, formal, foreign-led ‘training’ episodes and contrasts these with the more fluid, bilateral, approach to learning through co-working and mentoring.
Produktivitätsmanagement
Authors: Eisele Olaf , Jeske Tim , Lennings Frank 
Published: November 2020

ZusammenfassungDigitalisierung, Industrie 4.0 und künstliche Intelligenz (KI) bieten Unternehmen neue Chancen, um Produkte, Dienstleistungen und Leistungserstellungsprozesse zu gestalten und ihre Produktivität und damit Wettbewerbsfähigkeit zu verbessern. Gleichzeitig führen die damit verbundenen Veränderungen in der Arbeitswelt aber auch zu veränderten Rahmenbedingungen, Strukturen und Anforderungen. Um diesen Veränderungen gerecht zu werden, müssen bisherige Ansätze des Produktivitätsmanagements an die neuen Bedingungen angepasst werden. Nur so kann ein produktivitätssteigernder und damit erfolgreicher Einsatz neuer Technologien und digitaler Wandel hin zur vernetzten Produktion in einer Industrie 4.0 sichergestellt werden. Dieser Beitrag beschreibt die neuen Anforderungen an das Produktivitätsmanagement und gibt eine Handlungsempfehlung, wie dies in digitalisierten und vernetzten Arbeitswelten der Zukunft erfolgreich gestaltet und praktisch umgesetzt werden kann.
Towards spacetime entanglement entropy for interacting theories
Authors: Chen Yangang , Hackl Lucas , Kunjwal Ravi , Moradi Heidar , Yazdi Yasaman K. , Zilhão Miguel 
Published: November 2020

Abstract
Entanglement entropy of quantum fields in gravitational settings is a topic of growing importance. This entropy of entanglement is conventionally computed relative to Cauchy hypersurfaces where it is possible via a partial tracing to associate a reduced density matrix to the spacelike region of interest. In recent years Sorkin has proposed an alternative, manifestly covariant, formulation of entropy in terms of the spacetime two-point correlation function. This formulation, developed for a Gaussian scalar field theory, is explicitly spacetime in nature and evades some of the possible non-covariance issues faced by the conventional formulation. In this paper we take the first steps towards extending Sorkin’s entropy to non-Gaussian theories where Wick’s theorem no longer holds and one would expect higher correlators to contribute. We consider quartic perturbations away from the Gaussian case and find that to first order in perturbation theory, the entropy formula derived by Sorkin continues to hold but with the two-point correlators replaced by their perturbation-corrected counterparts. We then show that our results continue to hold for arbitrary perturbations (of both bosonic and fermionic theories). This is a non-trivial and, to our knowledge, novel result. Furthermore we also derive closed-form formulas of the entanglement entropy for arbitrary perturbations at first and second order. Our work also suggests avenues for further extensions to generic interacting theories.
Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells
Authors: Chen Oleg , Manig Friederike , Lehmann Loreen , Sorour Nagwa , Löck Steffen , Yu Zhanru , Dubrovska Anna , Baumann Michael , Kessler Benedikt M. , Stasyk Oleh , Kunz-Schughart Leoni A. 
Published: November 2020

AbstractArginine deprivation therapy (ADT) is a new metabolic targeting approach with high therapeutic potential for various solid cancers. Combination of ADT with low doses of the natural arginine analog canavanine effectively sensitizes malignant cells to irradiation. However, the molecular mechanisms determining the sensitivity of intrinsically non-auxotrophic cancers to arginine deficiency are still poorly understood. We here show for the first time that arginine deficiency is accompanied by global metabolic changes and protein/membrane breakdown, and results in the induction of specific, more or less pronounced (severe vs. mild) ER stress responses in head and neck squamous cell carcinoma (HNSCC) cells that differ in their intrinsic ADT sensitivity. Combination of ADT with canavanine triggered catastrophic ER stress via the eIF2α-ATF4(GADD34)-CHOP pathway, thereby inducing apoptosis; the same signaling arm was irrelevant in ADT-related radiosensitization. The particular strong supra-additive effect of ADT, canavanine and irradiation in both intrinsically more and less sensitive cancer cells supports the rational of ER stress pathways as novel target for improving multi-modal metabolic anti-cancer therapy.
On the Mathematical Foundations of Causal Fermion Systems in Minkowski Space
Authors: Oppio Marco 
Published: November 2020

AbstractThe emergence of the concept of a causal fermion system is revisited and further investigated for the vacuum Dirac equation in Minkowski space. After a brief recap of the Dirac equation and its solution space, in order to allow for the effects of a possibly nonstandard structure of spacetime at the Planck scale, a regularization by a smooth cutoff in momentum space is introduced, and its properties are discussed. Given an ensemble of solutions, we recall the construction of a local correlation function, which realizes spacetime in terms of operators. It is shown in various situations that the local correlation function maps spacetime points to operators of maximal rank and that it is closed and homeomorphic onto its image. It is inferred that the corresponding causal fermion systems are regular and have a smooth manifold structure. The cases considered include a Dirac sea vacuum and systems involving a finite number of particles and antiparticles.
Machine invention systems: a (r)evolution of the invention process?
Authors: Vasilescu Dragos-Cristian , Filzmoser Michael 
Published: November 2020

AbstractCurrent developments in fields such as quantum physics, fine arts, robotics, cognitive sciences or defense and security indicate the emergence of creative systems capable of producing new and innovative solutions through combinations of machine learning algorithms. These systems, called machine invention systems, challenge the established invention paradigm in promising the automation of – at least parts of – the innovation process. This paper’s main contribution is twofold. Based on the identified state-of-the-art examples in the above mentioned fields, key components for machine invention systems and their relations are identified, creating a conceptual model as well as proposing a working definition for machine invention systems. The differences and delimitations to other concepts in the field of machine learning and artificial intelligence, such as machine discovery systems are discussed as well. Furthermore, the paper briefly addresses the social and societal implications and limitations that come with the adoption of the technology. Because of their revolutionizing potential, there are widespread implications to consider from ethical and moral implications to policymaking and societal changes, like changes in the job structure. The discussion part approaches some of these implications, as well as solutions to some of the proposed challenges. The paper concludes by discussing some of the systemic benefits that can be accessed through machine invention.
Fate of MHCII in salmonids following 4WGD
Authors: Grimholt Unni , Lukacs Morten 
Published: November 2020

AbstractMajor histocompatibility complex (MHC) genes are key players in the adaptive immunity providing a defense against invading pathogens. Although the basic structures are similar when comparing mammalian and teleost MHC class II (MHCII) molecules, there are also clear-cut differences. Based on structural requirements, the teleosts non-classical MHCII molecules do not comply with a function similar to the human HLA-DM and HLA-DO, i.e., assisting in peptide loading and editing of classical MHCII molecules. We have previously studied the evolution of teleost class II genes identifying various lineages and tracing their phylogenetic occurrence back to ancient ray-finned fishes. We found no syntenic MHCII regions shared between cyprinids, salmonids, and neoteleosts, suggesting regional instabilities. Salmonids have experienced a unique whole genome duplication 94 million years ago, providing them with the opportunity to experiment with gene duplicates. Many salmonid genomes have recently become available, and here we set out to investigate how MHCII has evolved in salmonids using Northern pike as a diploid sister phyla, that split from the salmonid lineage prior to the fourth whole genome duplication (4WGD) event. We identified 120 MHCII genes in pike and salmonids, ranging from 11 to 20 genes per species analyzed where DB-group genes had the most expansions. Comparing the MHC of Northern pike with that of Atlantic salmon and other salmonids species provides a tale of gene loss, translocations, and genome rearrangements.
Metacontrol and joint action: how shared goals transfer from one task to another?
Authors: Liepelt Roman , Raab Markus 
Published: November 2020

AbstractIn most of our daily activities and in team sports, we interact with other individuals and do not act in isolation. Using a social variant of the standard two-choice Simon task, this study aims to test if competitive/cooperative processing modes (i.e., metacontrol states) change the degree of bodily self-other integration between two persons in joint action. In addition, and more exploratory the study tested if this effect depends on a shared group experience with the partner. Two participants shared a visual Simon task, so that each person basically performed complementary parts of the task, which transfers the paradigm into a go/no-go Simon task for each person. Before running this joint Simon task, we set both participants either in a competitive or a cooperative control state by means of a dyadic game, a manipulation aimed at testing possible goal transfer across tasks. We found significant joint Simon effects for participants who were in a competitive state and for participants who were in a cooperative state. The joint Simon effect for participants being in a competitive state was significantly smaller than for participants being in a cooperative state. When experiencing the goal induction together with the partner, the joint Simon effect was significantly decreased as when the induction was performed alone. Both effects (metacontrol state induction and shared experience) seem to be statistically independent of each other. In line with predictions of metacontrol state theory, our study indicated that abstract cognitive goal states can be transferred from one task to another task, able to affect the degree of bodily self-other integration across different task situations.
Is Dysphagia Under Diagnosed or is Normal Swallowing More Variable than We Think? Reported Swallowing Problems in People Aged 18–65 Years
Authors: Leslie Paula , Smithard David G. 
Published: November 2020

AbstractPurposeDysphagia prevalence in younger community dwelling adults and across nations is sparse. We investigated the prevalence of swallowing problems in an unselected cohort of people aged 18–65 years.MethodsThe EAT-10 Assessment Tool was converted into an anonymized online survey. Invitations were e-mailed to author contacts and onwards dispersal encouraged. Analysis was performed using non-parametric test for group comparison (Mann–WhitneyU) and Spearman’s rho correlation.ResultsFrom March 2014 to October 2017: 2054 responses (32 reported ages outside of 18–65 or undeclared) from Africa, Asia, Australasia/Oceania, Europe, and North and South America. Responses: 1,648 female, 364 male, (10 reported as both), median age 34, (range 18–65, mean 37.12, SD 12.40) years. Total EAT-10 scores: median 0 (range 0–36, mean 1.57, SD 3.49). EAT-10 score ≥ 3 (337) median 5 (range 3–36, mean 7.02 SD 5.91). Median age 36 (range 19–65, mean 37.81, SD 13.21) years. Declared sex was not statistically significantly associated with non-pathological vs. pathological EAT-10 score (p = 0.665). Female scores (median 0.00, mean 1.56, SD 3.338) were significantly higher than for males (median 0.00, mean 1.62, SD 4.161):U(Nfemale = 1648, Nmale = 364) = 275,420.000,z = − 2.677,p = 0.007. Age and EAT-10 score were not associated: femalesrs = − 0.043,p = 0.079,N = 1648, malesrs = − 0.003,p = 0.952,N = 364. Considerable impact on people: “I take ages to eat a main course … This is embarrassing and I often leave food even though I am still hungry.” (no diagnosis, EAT-10 = 17).ConclusionConcerns regarding swallowing exist in people undiagnosed with dysphagia, who may feel uncomfortable seeking professional help. Dysphagia may be under reported resulting in a hidden population. Subtle changes are currently seen as subtle markers of COVID-19. Further work is required to ensure that what is an essentially normal swallow does not become medicalized.
Analysis of relative bacterial activity and lactate dehydrogenase gene expression of caries-associated bacteria in a site-specific natural biofilm: an ex vivo study
Authors: Walther Carolin , Zumbülte Sandra , Faerber Christoph M. , Wierichs Richard Johannes , Meyer-Lueckel Hendrik , Conrads Georg , Henne Karsten , Esteves-Oliveira Marcella 
Published: November 2020

AbstractObjectivesDetecting bacterial activity is considered a promising approach to monitor shifts from symbiosis to dysbiosis in oral microbiome. The present study aimed at investigating both the relative bacterial activity and the lactate dehydrogenase (ldh) gene expression of caries-associated bacteria in a site-specific natural biofilm.Material and methodsSixty subjects (age, mean ± SE: 30.1 ± 1.4) were allocated to two groups: caries-free subjects (CF) or caries-active subjects (CA). CF presented one sound surface (CFS,n= 30). CA presented two donor sites: a cavitated caries lesion (CAC,n= 30) and a sound reference surface (CAS,n= 30). Real-time quantitative PCR (q-PCR) on species or genus level and total bacteria was performed targeting the 16S gene, the 16S rRNA, theldhgene, and the ldh mRNA (increasing 16S ribosomal RNA copy numbers can function as an indicator of increased energy metabolism). As the 16S rRNA abundance represents the number of ribosomes, while the 16S gene abundance represents the number of genomes, the quotient of the relative abundances functions as a measure for the relative bacterial activity (%).ResultsBothlactobacilliandS. mutansshowed the highest relative bacterial activity in CAC ((mean ± SE) 218 ± 60% and 61 ± 16%, respectively) and the lowest values for both sound reference surfaces (69 ± 48%; 8 ± 3%). Significant differences were found between CAC and CAS as well as between CAC and CFS for bothlactobacilliandS. mutans(p< 0.05). Theldhgene expression oflactobacilliandS. mutansonly showed moderate values in CAC (1.90E+03 ± 2.11E+03; 2.08E+04 ± 4.44E+04 transcripts/μl) and CFS (2.04E+03 ± 2.74E+03; 8.16E+03 ± 6.64E+03 transcripts/μl); consequently no significant differences were detected.Conclusion and clinical relevanceCaries-associated bacteria (lactobacilliandS. mutans) showed the highest relative bacterial activity in plaque of cavitated lesions, the lowest in sound surfaces, allowing the detection of a significant activity shift in health and disease for caries-active patients. However, no significant differences inldhgene expression could be determined.
DNA Hybridization-Based Differential Peptide Display Identified Potential Osteogenic Peptides
Authors: Hatakeyama Wataru , Lee Cliff , Da Silva John , Kim David M. , Nagai Shigemi , Kondo Hisatomo , Nagai Masazumi 
Published: November 2020

Abstract
A DNA hybridization-based differential peptide display (DPD) was developed for the screening of phage peptide library to find osteogenic peptides intended to bind to epigenetically induced osteogenic receptors on NIH/3T3 (3T3) cell surface. In the presence of DNA methylation inhibitor of 5-azacytidine (5AZC), an osteoblastic receptor of bone morphogenetic protein (BMP) receptor 1A (BMPR1A) was induced on the cell surface of NIH/3T3 fibroblasts. Cyclic heptamer-displaying phage library was screened against vehicle and 5AZC treated (Tx) 3T3 cells. Antisense oligo against library against library peptide coding DNA of control 3T3 cell bound phages were synthesized to subtract common binders from that of 5AZC-Tx 3T3 cell-bound phages that included 5AZC-induced receptor binders. The library peptide coding regions of conformational receptor binder-subtracted DPD were PCR-amplified and cloned into a plasmid vector specifically designed for short peptide expression. No unique binder was identified when 96 clones were randomly picked from the third round of panning against 5AZC-treated 3T3 cells, suggesting miscellaneous bindings to cell surface proteins. Unique binders showing homology to known function proteins were successfully identified when constitutive receptor binders were subtracted from 5AZC-induced protein binders. Some of identified peptides significantly increased alkaline phosphatase activity in 5AZC-Tx 3T3 cells. DPD can be a useful tool to screen functional peptide bindings to cell surface receptors.

Graphic Abstract
Pore-Scale Transport and Two-Phase Fluid Structures in Fibrous Porous Layers: Application to Fuel Cells and Beyond
Authors: Farzaneh Meisam , Ström Henrik , Zanini Filippo , Carmignato Simone , Sasic Srdjan , Maggiolo Dario 
Published: November 2020

AbstractWe present pore-scale simulations of two-phase flows in a reconstructed fibrous porous layer. The three-dimensional microstructure of the material, a fuel cell gas diffusion layer, is acquired via X-ray computed tomography and used as input for lattice Boltzmann simulations. We perform a quantitative analysis of the multiphase pore-scale dynamics, and we identify the dominant fluid structures governing mass transport. The results show the existence of three different regimes of transport: a fast inertial dynamics at short times, characterised by a compact uniform front, a viscous-capillary regime at intermediate times, where liquid is transported along a gradually increasing number of preferential flow paths of the size of one–two pores, and a third regime at longer times, where liquid, after having reached the outlet, is exclusively flowing along such flow paths and the two-phase fluid structures are stabilised. We observe that the fibrous layer presents significant variations in its microscopic morphology, which have an important effect on the pore invasion dynamics, and counteract the stabilising viscous force. Liquid transport is indeed affected by the presence of microstructure-induced capillary pressures acting adversely to the flow, leading to capillary fingering transport mechanism and unstable front displacement, even in the absence of hydrophobic treatments of the porous material. We propose a macroscopic model based on an effective contact angle that mimics the effects of the such a dynamic capillary pressure. Finally, we underline the significance of the results for the optimal design of face masks in an effort to mitigate the current COVID-19 pandemic.