bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS TINGKAT KEMANDIRIAN KOPERASI MELALUI PENGELOLAAN MODAL PADA KOPERASI PEGAWAI NEGERI SIPIL (KPRI) OBOR KOTA BIMA TAHUN 2016-2019
Authors: Wahyuni Wahyuni , Mukhsin Zainuddin , Mukhlis Mukhlis 
Published: December 2020

Tujuan penelitian ini adalah untuk mengetahui tingkat kemandirian koperasi melalui pengelolaan modal pada Koperasi Pegawai Negeri Sipil (KPRI) OBOR Kota Bima. Penelitian ini menggunakan pendekatan kuantitatif. Subyek dalam penelitian ini adalah pengurus koperasi sebanyak 5 orang. Teknik analisis data menggunakan analisis statistik dengan menggunakan rumus likuiditas, solvabilitas, rasio Rentabilitas Ekonomi (RE). Dari hasil perhitungan diperoleh hasil yaitu rasio likuiditas pada KPRI OBOR Kota Bima yang menunjukan tingkat kemampuan untuk memenuhi kewajiban jangka pendeknya dengan membandingkan harta atau aktiva lancar dan hutang lancar. Tahun 2016 yaitu Rp. 12.676.106.473 (aktiva lancar) dan Rp. 2.814.718.704 (hutang lancar) diperoleh rasio likuiditas sebesar 4,50%, untuk tahun 2017 yaitu Rp. 12.612.400.014 (aktiva lancar) dan Rp. 1.938.480.350 (hutang lancar) diperoleh rasio likuiditas sebesar 6,51%, untuk tahun 2018 yaitu Rp. 13.568.250.172 (aktiva lancar) dan Rp. 1.498.623.500 (hutang lancar) diperoleh rasio likuiditas sebesar 9,05% dan untuk tahun 2019 sebesar Rp. 16.206.213.058 (aktiva lancar) dan Rp. 3.397.270.220 (hutang lancar) diperoleh rasio likuiditas sebesar 4,77%, yang artinya dari rasio likuiditas KPRI OBOR didalam kemampuannya untuk memenuhi kewajiban finansialnya segera harus dipenuhi, dikategorikan sangat baik karena hasil perhitungan rasio likuiditas kurang dari nilai standar yantu sebesar 125%. Sedangkan rasio solvabilitas yang dicapai KPRI OBOR Kota Bima dengan membandingkan antara jumlah aktiva dengan jumlah hutang. Untuk tahun 2016 yaitu Rp. 13.050.928.201 (jumlah aktiva) dan Rp. 2.814.718.704 (jumlah hutang) atau mencapai 4,64%, untuk tahun 2017 yaitu Rp. 12.982.967.677 (jumlah aktiva) dan Rp. 1.938.480.350 (jumlah hutang) atau mencapai 6,70%, untuk tahun 2018 yaitu Rp. 13.962.068.635 (jumlah aktiva) dan Rp. 1.498.623.500 (jumlah hutang) atau mencapai 9,32%, dan untuk tahun 2019 yaitu Rp. 16.530.498.878 (jumlah aktiva) dan Rp. 3.397.270.220 (jumlah hutang) atau mencapai 4,87% yang berarti tingkat kemampuan KPRI OBOR untuk membayar hutang-hutang jangka panjang, dikategorikan sangat efisien. Karena hasil perhitungan rasio solvabilitas lebih kecil dari nilai standar yang ditentukan sebesar 152%. Untuk hasil perhitungan rasio Rentabilitas Ekonomi pada tahun 2016 dengan nilai laba usaha Rp. 672.288.611 dan nilai modal usaha Rp. 9.861.385.769 mendapatkan rasio Rentabilitas Ekonomi (RE) sebesar 0,07%, untuk tahun 2017 dengan nilai laba usaha Rp. 740.823.771 dan nilai modal usaha Rp. 10.673.919.664 mendapatkan rasio Rentabilitas Ekonomi (RE) sebesar 0,07%, untuk tahun 2018 dengan nilai laba usaha Rp. 778.767.543 dan nilai modal usaha Rp. 12.069.626.672 mendapatkan rasio Rentabilitas Ekonomi (RE) sebesar 0,06%, dan untuk tahun 2019 dengan nilai laba usaha Rp. 638.266.519 dan nilai modal usaha Rp. 12.808.943.838 mendapatkan rasio Rentabilitas Ekonomi (RE) sebesar 0,05%.
Case Report: ST-Segment Elevation in a Man With Acute Pericarditis
Authors: Li Yi-Ming , Jia Yu-Heng , Tsauo Jiay-Yu , Wang Si , Peng Yong 
Published: December 2020

Background: Acute pericarditis is a rapid inflammatory condition of the pericardium with both infectious and non-infectious etiology. Most acute pericarditis is self-limited, with a small portion evolving rapidly. The definitive diagnosis of acute pericarditis often requires detailed physical examination, ECG, echocardiography, blood analysis and chest X-ray. It's usually challenging to distinguish acute pericarditis from ST-elevated myocardial infarction (STEMI) due to the similar ECG characteristics (ST segment change). Here we present a case of purulent pericarditis probably caused by esophageal perforation.Case: A 52 year-old male presented with chest pain and dyspnea for 16 h. ST-segment elevation and positive cardiac markers lead to the initial diagnosis of ST-elevated myocardial infarction. Coronary angiography demonstrated normal coronary artery, while transthoracic echocardiography (TTE) showed massive pericardial effusion. Then, pericardiocentesis was performed with 250 ml of yellowish-green pus-like fluid extracted. A detailed history examination revealed a week history of possible esophageal perforation caused by a fishbone. And a further computed tomography (CT) demonstrated the presence of pneumomediastinum, and effusions in mediastinum, which lead to the diagnosis of purulent pericarditis. However, the patient's family refused further treatment and the patient died soon after discharge.Conclusion: The differential diagnosis of chest pain should include acute pericarditis, which can be equally critical and fatal. And it's important to note the peculiar characteristics of acute pericarditis, which include concave and diffused ST-segment elevation, PR segment depression, and the ratio of ST-segment elevation to T wave &gt;0.24 in lead V6. Moreover, comprehensive medical history and physical examination are crucial to the differential diagnosis of chest pain patients.
Clinical Utility of a Nomogram for Predicting 30-Days Poor Outcome in Hospitalized Patients With COVID-19: Multicenter External Validation and Decision Curve Analysis
Authors: Zhang Bin , Liu Qin , Zhang Xiao , Liu Shuyi , Chen Weiqi , You Jingjing , Chen Qiuying , Li Minmin , Chen Zhuozhi , Chen Luyan , Chen Lv , Dong Yuhao , Zeng Qingsi , Zhang Shuixing 
Published: December 2020

Aim: Early detection of coronavirus disease 2019 (COVID-19) patients who are likely to develop worse outcomes is of great importance, which may help select patients at risk of rapid deterioration who should require high-level monitoring and more aggressive treatment. We aimed to develop and validate a nomogram for predicting 30-days poor outcome of patients with COVID-19.Methods: The prediction model was developed in a primary cohort consisting of 233 patients with laboratory-confirmed COVID-19, and data were collected from January 3 to March 20, 2020. We identified and integrated significant prognostic factors for 30-days poor outcome to construct a nomogram. The model was subjected to internal validation and to external validation with two separate cohorts of 110 and 118 cases, respectively. The performance of the nomogram was assessed with respect to its predictive accuracy, discriminative ability, and clinical usefulness.Results: In the primary cohort, the mean age of patients was 55.4 years and 129 (55.4%) were male. Prognostic factors contained in the clinical nomogram were age, lactic dehydrogenase, aspartate aminotransferase, prothrombin time, serum creatinine, serum sodium, fasting blood glucose, and D-dimer. The model was externally validated in two cohorts achieving an AUC of 0.946 and 0.878, sensitivity of 100 and 79%, and specificity of 76.5 and 83.8%, respectively. Although adding CT score to the clinical nomogram (clinical-CT nomogram) did not yield better predictive performance, decision curve analysis showed that the clinical-CT nomogram provided better clinical utility than the clinical nomogram.Conclusions: We established and validated a nomogram that can provide an individual prediction of 30-days poor outcome for COVID-19 patients. This practical prognostic model may help clinicians in decision making and reduce mortality.
Accuracy Improvement of IOL Power Prediction for Highly Myopic Eyes With an XGBoost Machine Learning-Based Calculator
Authors: Wei Ling , Song Yunxiao , He Wenwen , Chen Xu , Ma Bo , Lu Yi , Zhu Xiangjia 
Published: December 2020

Purpose: To develop a machine learning-based calculator to improve the accuracy of IOL power predictions for highly myopic eyes.Methods: Data of 1,450 highly myopic eyes from 1,450 patients who had cataract surgeries at our hospital were used as internal dataset (train and validate). Another 114 highly myopic eyes from other hospitals were used as external test dataset. A new calculator was developed using XGBoost regression model based on features including demographics, biometrics, IOL powers, A constants, and the predicted refractions by Barrett Universal II (BUII) formula. The accuracies were compared between our calculator and BUII formula, and axial length (AL) subgroup analysis (26.0–28.0, 28.0–30.0, or ≥30.0 mm) was further conducted.Results: The median absolute errors (MedAEs) and median squared errors (MedSEs) were lower with the XGBoost calculator (internal: 0.25 D and 0.06 D2; external: 0.29 D and 0.09 D2) vs. the BUII formula (all P ≤ 0.001). The mean absolute errors and were 0.33 ± 0.28 vs. 0.45 ± 0.31 (internal), and 0.35 ± 0.24 vs. 0.43 ± 0.29 D (external). The mean squared errors were 0.19 ± 0.32 vs. 0.30 ± 0.36 (internal), and 0.18 ± 0.21 vs. 0.27 ± 0.29 D2 (external). The percentages of eyes within ±0.25 D of the prediction errors were significantly greater with the XGBoost calculator (internal: 49.66 vs. 29.66%; external: 78.28 vs. 60.34%; both P &lt; 0.05). The same trend was in MedAEs and MedSEs in all subgroups (internal) and in AL ≥30.0 mm subgroup (external) (all P &lt; 0.001).Conclusions: The new XGBoost calculator showed promising accuracy for highly or extremely myopic eyes.
Development and Validation of Nomograms Predicting the Overall and the Cancer-Specific Survival in Endometrial Cancer Patients
Authors: Li Xingchen , Fan Yuan , Dong Yangyang , Cheng Yuan , Zhou Jingyi , Wang Zhiqi , Li Xiaoping , Wang Jianliu 
Published: December 2020

Background: The present study was aimed at developing nomograms estimating the overall survival (OS) and cancer-specific survival (CSS) of endometrial cancer (EC)-affected patients.Patients and Methods: We retrospectively collected 145,445 EC patients between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Independent prognostic factors were identified via univariate and multivariate Cox analyses. These risk factors were used to establish nomograms to predict 3- and 5-year OS and CSS rates. Internal and external data were used for validation. The predictive accuracy and discriminative ability were measured by using concordance index (C-index) and risk group stratification.Results: A total of 63,510 patients were collected and randomly assigned into the training cohort (n = 42,340) and the validation cohort (n = 21,170). Age at diagnosis, marital status, tumor size, histologic type, lymph node metastasis, tumor grade, and clinical stage were identified as independent prognostic factors for OS and CSS (p &lt; 0.05 according to multivariate Cox analysis) and were further used to construct the nomograms. The area under the receiver operating characteristics (ROC) curve was greater than that of International Federation of Gynecology and Obstetrics (FIGO) staging system for predicting OS (0.83 vs. 0.73, p &lt; 0.01) and CSS (0.87 vs. 0.79, p &lt; 0.01) in the training cohort. The stratification into different risk groups ensured a significant distinction between survival curves within different FIGO staging categories.Conclusion: We constructed and validated nomograms that accurately predicting OS and CSS in EC patients. The nomograms can be used for estimating OS and CSS of individual patients and establishing their risk stratification.
An Integrative Pan-Cancer Analysis Revealing LCN2 as an Oncogenic Immune Protein in Tumor Microenvironment
Authors: Xu Wen-Xiu , Zhang Jian , Hua Yu-Ting , Yang Su-Jin , Wang Dan-Dan , Tang Jin-Hai 
Published: December 2020

BackgroundLipocalin 2 (LCN2), an innate immune protein, plays a pivotal role in promoting sterile inflammation by regulating immune responses. However, the role of LCN2 in diverse cancers remains poorly defined. This research aimed to investigate the correlation between LCN2 expression and immunity and visualize its prognostic landscape in pan-cancer.MethodsRaw data in regard to LCN2 expression in cancer patients were acquired from TCGA and GTEx databases. Besides, we investigated the genomic alterations, expression pattern, and survival analysis of LCN2 in pan-cancer across numerous databases, including cBioPortal and GEPIA database. The correlation between LCN2 expression and tumor immune infiltration was explored via TIMER, and we utilized CIBERSORT and ESTIMATE computational methods to assess the proportion of tumor-infiltrating immune cells (TIICs) and the amount of stromal and immune components from TCGA database. Protein–Protein Interaction analysis was performed in GeneMANIA database, and gene functional enrichment was performed by Gene Set Enrichment Analysis (GSEA).ResultsOn balance, tumor tissue had a higher LCN2 expression level compared with that in normal tissue. Elevated expression of LCN2 was related to poor clinical regimen with OS and RFS. There were significant positive correlations between LCN2 expression and TIICs, including CD8+ T cells, CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. Moreover, markers of TIICs exhibited different LCN2-related immune infiltration patterns. GSEA analysis showed that the expression of LCN2 was related to retinol metabolism, drug metabolism cytochrome P450 and metabolism of xenobiotics by cytochrome P450.ConclusionsThese findings suggested that LCN2 might serve as a biomarker for immune infiltration and poor prognosis in cancers, shedding new light on therapeutics of cancers.
Case Report: Two Cases of Chemotherapy Refractory Metastatic Penile Squamous Cell Carcinoma With Extreme Durable Response to Pembrolizumab
Authors: Chahoud Jad , Skelton William Paul , Spiess Philippe E. , Walko Christine , Dhillon Jasreman , Gage Kenneth L. , Johnstone Peter A. S. , Jain Rohit K. 
Published: December 2020

BackgroundPenile squamous cell carcinoma (PSCC) is a rare malignancy, and those patients with metastatic disease have limited treatment options. Treatment is largely comprised of platinum-based chemotherapy; however, patients progressing after initial chemotherapy have a median overall survival (OS) of less than 6 months. Based on a high percentage of PD-L1 expression in patients with PSCC, and its biological similarities to other squamous cell carcinomas, we present two patient cases treated with pembrolizumab with extraordinary durable treatment response far beyond treatment with standard therapy.Main BodyThe first patient is a 64 year old male with PSCC who was treated with neoadjuvant chemotherapy, partial penectomy, and adjuvant radiation prior to developing metastatic disease. He had a high TMB (14 mutations/Mb) and was started on pembrolizumab with a complete response, which has been maintained for 38 months. The second patient is an 85 year old male with PSCC who was treated with partial penectomy and adjuvant chemotherapy and radiation prior to developing metastatic disease. He had positive PD-L1 expression CPS 130) and was started on pembrolizumab with a partial response, which has been maintained for 18 months after starting treatment.ConclusionsThese two cases of extreme durable response with pembrolizumab (with molecular data including TMB and PD-L1 status) represent a significant clinical benefit in this patient population. With limited treatment options that result in a median OS of less than 6 months, along with the toxicity profile of chemotherapy which may not be tolerated in elderly patients with comorbidities, this survival benefit with pembrolizumab, along with advances in tumor sequencing and clinical trials shows that there is a potentially significant benefit with novel therapies in this patient population.
Magnetic Non-invasive Auricular Acupuncture During Eye-Exam for Retinopathy of Prematurity in Preterm Infants: A Multicentre Randomized Controlled Trial
Authors: Gan Kimberly M. L. , Oei Ju-Lee , Quah-Smith Im , Kamar Azanna A. , Lordudass Alexis A. D. , Liem Kian D. , Lindrea Kwee Bee , Daly Mary , Gaunker Nilima , Mangat Avneet K. , Yaskina Maryna , Schmölzer Georg M. 
Published: December 2020

Background: Eye exam for Retinopathy of prematurity (ROP) is a painful procedure and pharmacological analgesia might be ineffective. We hypothesized that magnetic auricular acupuncture (MAA) compared to placebo will decrease pain during ROP exam in preterm infants.Methods: Multicentre randomized controlled trial conducted in three hospitals (Australia, Canada, and Malaysia). Eligibility: &gt;32 weeks, ROP exam, not sedated, and parental consent. A total of 100 infants were randomized (1:1) to MAA (n = 50) or placebo (n = 50). MAA stickers or placebo were placed on both ears by an unblinded investigator. Pain was assessed using the Premature Infant Pain Profile. Primary analyses were by intention-to-treat. ClinicalTrials.gov:NCT03650621.Findings: The mean (standard deviation, SD) gestation, birthweight, and postnatal age were (MAA 28(3) vs. placebo 28(2) weeks; MAA 1,057(455) vs. placebo 952(273) g; MAA 7(3) vs. placebo 7(3) weeks. Placebo infants had significantly higher PIPP scores during [mean difference 1.6 points (95%CI 0.1–3.1)] and 1 h mean difference 1.5 points (95%CI 0.7–2.2) after the procedure (p &lt; 0.03). Heart rate was lower (173(22) vs. 184(18)/min) and oxygen saturations were higher (93.8(6.2) vs. 91.7(6.1)%, p = 0.05) in MAA infants. No adverse effects.Interpretation: MAA may reduce physiological pain responses during and after ROP exam in preterm infants. Assessment of long-term effects are warranted.Clinical trial registration: www.ClinicalTrials.gov, identifier: NCT03650621.
A Preliminary Investigation of the Views of People With Parkinson's (With and Without Psychosis) and Caregivers on Participating in Clinical Trials During the Covid-19 Pandemic: An Online Survey
Authors: McGoohan Katie , Amjad Anneesa , Ratcliffe Natasha , Bhattacharyya Sagnik , Granville Gillian , Sullivan Matthew , Gosden Lesley , Aarsland Dag , Chaudhuri K. Ray , ffytche Dominic , Ballard Clive , Velayudhan Latha 
Published: December 2020

Background: The coronavirus pandemic is having a profound impact on non-COVID-19 related research, including the delivery of clinical trials for patients with Parkinson's disease.Objectives: A preliminary investigation to explore the views of Parkinson's disease (PD) patients, with and without experience of psychosis symptoms, and carers on the resumption of clinical research and adaptations to trials in light of COVID-19.Methods: An anonymous self-administered online survey was completed by 30 PD patients and six family members/carers via the Parkinson's UK Research Support Network to explore current perceptions on taking part in PD research and how a planned clinical trial for psychosis in PD may be adapted so participants feel safe.Results: Ninety-one percent of respondents were enthusiastic about the continuation of non-COVID-19 related research as long as certain safety measures were in place. Ninety-four percent stated that they would be happy to complete assessments virtually. However, they noted that care should be taken to ensure that this does not exclude participants, particularly those with more advanced PD who may require assistance using portable electronic devices. Regular and supportive communication from the research team was also seen as important for maintaining the psychological well-being of participants while taking part in the trial.Conclusions: In the era of COVID-19 pandemic, standard approaches will have to be modified and rapid adoption of virtual assessments will be critical for the continuation of clinical research. It is important that alongside the traditional methods, new tools are developed, and older ones validated for virtual assessments, to allow safe and comprehensive assessments vital for ongoing research in people with Parkinson's.
Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases
Authors: Marei Reham M. , Emara Mohamed M. , Elsaied Omar M. , Nasrallah Gheyath K. , Chivese Tawanda , Al-Romaihi Hamad E. , Althani Mohamed H. , Al Thani Asmaa A. , Farag Elmoubasher A. , Yassine Hadi M. 
Published: December 2020

Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly and those with chronic illness but can also be fatal in younger age groups. This article is the first comprehensive analysis of the epidemiological and clinical outcomes of the travel-associated SARS-CoV-2 cases until April 19, 2020.Methods: Demographic and clinical data of travel-associated SARS-CoV-2 cases were collected for the period between January 16, 2020 and April 19, 2020. More than one hundred and eighty databases were searched, including the World Health Organization (WHO) database, countries' ministries websites, and official media sites. Demographic and clinical data were extracted and analyzed.Results: A total of 1,186 cases from 144 countries meeting the inclusion criteria were reported and included in the analysis. The mean age of the cases was 44 years, with a male to female ratio of 1.6:1. Travel-associated cases originated from more than 40 countries, with China, Italy, and Iran reporting the highest numbers at 208, 225, and 155, respectively. Clinical symptoms varied between patients, with some reporting symptoms during the flights (117 cases; 9.87%). A total of 312 (26.31%) cases were hospitalized, of which 50 cases (4.22%) were fatal.Conclusion: Major gaps exist in the epidemiology and clinical spectrum of the COVID-19 travel-associated cases due to a lack of reporting and sharing data of many counties. The identification and implementation of methodologies for measuring traveler's risk to coronavirus would help in minimizing the spread of the virus, especially in the next waves.
Vitamin D level in Patients with Prediabetes
Authors: GULTEKİN Mehmet , ÖZDEMİR Nilüfer , ONUR Ece , HEKİMSOY Zeliha 
Published: December 2020

Purpose
Vitamin D deficiency may cause glucose intolerance, diabetes mellitus, and metabolic syndrome. However, there are conflicting data the relationship between vitamin D levels and prediabetes in the literature. Our aim in this study is to evaluate serum 25-hydroxyvitamin D levels in prediabetic patients and to determine if vitamin D deficiency or insufficiency is a factor for developing prediabetes.
Material and Method:
Our study included a total of 220 patients, including 85 with isolated Impaired Fasting Glucose (IFG), 50 with isolated Impaired Glucose Tolerance (IGT), and 85 with combined IFG and IGT, and 80 healthy normoglycemic individuals similar in age, gender and BMI.
Results
The mean vitamin D levels between the patient group diagnosed as IGT and IFG+IGT and the control group were statistically significantly different (IGT: 11.69±6.48 ng/ml vs. control group: 16.63±9.78 ng/ml, p
Entre lo virtual y lo real
Authors: Bocanegra Risco Tania Carolina 
Published: December 2020

A partir de la creciente crisis sanitaria producida por la COVID-19, nuestro entorno económico, social y judicial ha sufrido diversos cambios; entre ellos, se encuentran las medidas adoptadas por la judicatura para no dejar de tutelar los derechos y continuar con «normalidad» su labor. En el presente artículo se realizaráun breve comentario, aclaración y análisis sobre la Directiva n.o 007-2020-CE-PJ que implementó el «Proceso Simplificado y Virtual de Alimentos para Niña, Niño y Adolescente», aprobada por Resolución Administrativa del Consejo Ejecutivo del Poder Judicial n.° 000167-2020-CE-PJ. Para ello, se analizarán sus principalesalcances y modificaciones relevantes respecto al proceso tradicional, y también se tomará en consideración la experiencia de la Corte Superior de Justicia de La Libertad respecto a la implementación del formulario virtual de demanda de alimentos.