bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Testing of a Hyperlearning Model for Design of an Online Critical Care Course
Authors: Jeffries Pamela R. 
Published: February 2020

Many U.S. colleges and universities are discovering innovative and exciting ways of using information technology to promote the process of teaching and learning and to extend education to new populations of students. Nurse educators in academia and service settings are developing interactive e-learning programs or courses to meet this need, and to either enhance practice concepts and basic skills or orient new associates to the clinical organization. In continuing education programs, students need flexibility and convenience to concurrently meet their personal and academic goals, and consumer demand for online instruction is increasing. The challenge is to prepare a comprehensive, high-quality, cost-effective e-learning course to meet educational standards and competencies.
To meet this challenge, an instructional design model, the Hyperlearning Model, was developed based on Chickering and Gamson's principles of best practices in undergraduate education, to guide the development of an online course for basic critical care content. In this article, I describe the creation and testing of an instructional design model for developing content in this online course.
DISCOVERY OF TYPE 3 VON WILLEBRAND DISEASE IN A COHORT OF PATIENTS WITH SUSPECTED HEMOPHILIA A IN CÔTE D’IVOIRE
Authors: Adjambri Adia Eusèbe , Bouvier Sylvie , N'guessan Roseline , N’draman-Donou Emma , Yayo-Ayé Mireille , Meledje Marie-France , Adjé Missa Louis , Sawadogo Duni 
Published: February 2020

Abstract
Aim : Type 3 von Willebrand disease (VWD) is the most severe form of VWD, characterized by a near-total absence of von Willebrand factor (vWF) leading to a huge deficiency in plasmatic factor VIII (FVIII). VWD may be confused with hemophilia A, sometimes leading to misdiagnosis. The purpose of this work was to finalize the biological diagnosis of patients with FVIII activity deficiency in Abidjan, in order to guide the best type of management. Methods: We conducted a cross-sectional descriptive study from June 2018 to April 2019. Forty-nine patients, all of whom had lower FVIII levels or had been referred for bleeding disorder, were monitored in the clinical hematology service. Pro-coagulant activity of coagulation factors was performed in Abidjan. The assays for von Willebrand antigen and activity were performed at Nîmes University Hospital in France. Results: The mean age of patients was 13.8 years (1 – 65) and 86% were Ivorian. FVIII deficiency was discovered during a biological checkup, circumcision or post-traumatic bleeding, in 33%, 31% and 29% respectively. The FVIII level of patients was classified as severe (89.8%), moderate (8.2%) and mild (2%). Only one patient had a quantitative deficiency of von Willebrand factor (vWF: Ag <3%) with undetectable von Willebrand factor activity (vWF: Ac) and an FVIII level <1%. Conclusion: Not all of the constitutive deficits of FVIII are hemophilia A. It was very important to assess the Willebrand factor of these patients followed in Côte d'Ivoire for whom hemophilia A had been suspected.
Determination of the mixing ratio of a flowing gas mixture with self-actuated microcantilevers
Authors: Stauffenberg Jaqueline , Durstewitz Steve , Hofmann Martin , Ivanov Tzvetan , Holz Mathias , Ehrhardt Waleed , Riegel Wolf-Ulrich , Zöllner Jens-Peter , Manske Eberhard , Rangelow Ivo 
Published: February 2020

Abstract. Microcantilevers offer a wide range of applications in sensor and measurement technology. In this work cantilever sensors are used as flow
sensors. Most conventional flow sensors are often only calibrated for one type of gas and allow an analysis of gas mixtures only with increased
effort. The sensor used here is a cantilever positioned vertically in the flow channel. It is possible to operate the sensor in dynamic and static
mode. In the dynamic mode the cantilever is oscillating. Resonance frequency, resonance amplitude and phase are measured. In static mode, the
bending of the cantilever is registered. The combination of the modes enables the different measured variables to be determined simultaneously. A flow
influences the movement behaviour of the sensor, which allows the flow velocity to be deduced. In addition to determining the flow velocity, it is also
possible to detect different types of gas. Each medium has certain properties (density and viscosity) which have different effects on the bending of
the sensor. As a result, it is possible to measure the mixing ratio of a known binary gas mixture and their flow velocity simultaneously with
a single sensor. In this paper this is investigated using the example of the air–carbon-dioxide mixture.
Impact of Diabetes Mellitus on Knee Osteoarthritis Pain and Physical and Mental Status: Data From the Osteoarthritis Initiative
Authors: Eitner Annett , Culvenor Adam G. , Wirth Wolfgang , Schaible Hans‐Georg , Eckstein Felix 
Published: February 2020

ObjectiveDiabetes mellitus (DM) appears to increase osteoarthritic knee pain, which may be related to greater adiposity and more advanced disease status often observed in individuals with osteoarthritis (OA) and DM. We aimed to assess whether OA knee pain and health status are worse in individuals with OA and DM, independent of these potential confounders.MethodsWe included 202 OA participants with DM and 2,279 without DM from the Osteoarthritis Initiative. Knee pain was evaluated using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and a numeric rating scale (NRS). Physical and mental status were assessed by the Medical Outcomes Study Short Form 12 (SF‐12) questionnaire, physical component summary (PCS) score and mental component summary (MCS) score, and by the Center for Epidemiologic Studies Depression Scale (CES‐D). Linear regression models assessed the influence of DM, adjusted for age, sex, body mass index (BMI), and radiographic severity.ResultsOA participants with DM reported worse knee pain and greater physical and mental issues compared with participants without DM. Individuals with DM had worse KOOS pain (β = –4.72 [95% confidence interval (95% CI) –7.22, –2.23]) and worse NRS pain (β = 0.42 [95% CI 0.04, 0.80]) independent of BMI, OA severity, age, and sex. The negative influence of DM was also apparent for SF‐12 PCS (β = –3.49 [95% CI –4.73, –2.25]), SF‐12 MCS (β = –1.42 [95% CI –2.57, –0.26]), and CES‐D (β = 1.08 [95% CI 0.08, 2.08]).ConclusionIndividuals with knee OA experience on average higher pain intensity and a worse physical and mental health status if they have DM. Linear regression models show that DM is a risk factor for higher pain, in addition to and independent of greater BMI and radiographic OA severity.
Bi‐Layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue
Authors: Chen Ying , Guo Chengchen , Manousiouthakis Eleana , Wang Xiuli , Cairns Dana M. , Roh Terrence T. , Du Chuang , Kaplan David L. 
Published: February 2020

AbstractDesigning biomimetic scaffolds with in vivo–like microenvironments using biomaterials is an essential component of successful tissue engineering approaches. The intestinal smooth muscle layers exhibit a complex tubular structure consisting of two concentric muscle layers in which the inner circular layer is orthogonally oriented to the outer longitudinal layer. Here, a 3D bi‐layered tubular scaffold is presented based on flexible, mechanically robust, and well aligned silk protein microfibers to mimic the native human intestinal smooth muscle structure. The scaffolds are seeded with primary human intestinal smooth muscle cells to replicate intestinal muscle tissues in vitro. Characterization of the tissue constructs reveals good biocompatibility and support for cell alignment and elongation in the different scaffold layers to enhance cell differentiation and functions. Furthermore, the engineered smooth muscle constructs support oriented neurite outgrowth, a requisite step to achieve functional innervation. These results suggest these microfiber scaffolds as functional templates for in vitro regeneration of human intestinal smooth muscle systems. The scaffolding provides a crucial step toward engineering functional human intestinal tissue in vitro, as well as engineering other types of smooth muscles in terms of their similar phenotypes. Such utility may lead to a better understanding of smooth muscle associated diseases and treatments.
Halide Double‐Perovskite Light‐Emitting Centers Embedded in Lattice‐Matched and Coherent Crystalline Matrix
Authors: Dai Chen‐Min , Zhang Tao , Wu Yu‐Ning , Chen Shiyou 
Published: February 2020

AbstractThrough first‐principles calculations, it is found that two lattice‐matched halide double‐perovskites, Cs2NaBiBr6 and Cs2AgBiBr6, have a type‐I band alignment and can form highly miscible alloys in which the disordering makes the bandgaps become direct and activates the direct transition from the valence to conduction band edge, leading to a strong optical absorption and high radiative recombination rate. The bandgaps of the alloys are tunable in a wide range of 1.93–3.24 eV, while the lattice constants remain unchanged. This advantage inspires the design of a coherent crystalline matrix based on Cs2(Na,Ag)BiBr6 alloys, in which the Ag‐rich and narrower‐bandgap regions are embedded in the Na‐rich and wide‐bandgap region with lattice‐matched and coherent interfaces. The type‐I band alignment drives the photogenerated excitons into the narrower‐bandgap Ag‐rich regions, so the regions become light‐emitting centers with a high photoluminescence quantum yield (PLQY). The bandgaps of the Ag‐rich regions are tunable, so the color of emitted light can be adjusted, making a broadband emission possible. Such kind of coherent crystalline matrix with high‐PLQY and broadband emission can also be fabricated based on the alloys of other lattice‐matched halide double‐perovskites, demonstrating the flexibility of band structure engineering in the coherent heterostructures of various halide double‐perovskites.
Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs
Authors: Jung Yei Hwan , Kim Jong Uk , Lee Ju Seung , Shin Joo Hwan , Jung Woojin , Ok Jehyung , Kim Tae‐il 
Published: February 2020

AbstractThe rapid pace of progress in implantable electronics driven by novel technology has created devices with unconventional designs and features to reduce invasiveness and establish new sensing and stimulating techniques. Among the designs, injectable forms of biomedical electronics are explored for accurate and safe targeting of deep‐seated body organs. Here, the classes of biomedical electronics and tools that have high aspect ratio structures designed to be injected or inserted into internal organs for minimally invasive monitoring and therapy are reviewed. Compared with devices in bulky or planar formats, the long shaft‐like forms of implantable devices are easily placed in the organs with minimized outward protrusions via injection or insertion processes. Adding flexibility to the devices also enables effortless insertions through complex biological cavities, such as the cochlea, and enhances chronic reliability by complying with natural body movements, such as the heartbeat. Diverse types of such injectable implants developed for different organs are reviewed and the electronic, optoelectronic, piezoelectric, and microfluidic devices that enable stimulations and measurements of site‐specific regions in the body are discussed. Noninvasive penetration strategies to deliver the miniscule devices are also considered. Finally, the challenges and future directions associated with deep body biomedical electronics are explained.
An Integrated Flexible All‐Nanowire Infrared Sensing System with Record Photosensitivity
Authors: Ran Wenhao , Wang Lili , Zhao Shufang , Wang Depeng , Yin Ruiyang , Lou Zheng , Shen Guozhen 
Published: February 2020

AbstractInfrared (IR) photodetectors are a key optoelectronic device and have thus attracted considerable research attention in recent years. Photosensitivity is an increasingly important device performance parameter for nanoscale photodetectors and image sensors, as it determines the ultimate imaging quality and contrast. However, photosensitivities of state‐of‐the‐art low‐dimensional nanostructure‐based IR detectors are considerably low, limiting their practical applications. Herein, a biomimetic IR detection amplification (IRDA) system that boosts photosensitivity by several orders of magnitude by introducting nanowire field effect transistors (FETs), resulting in a peak photosensitivity of 7.6 × 104 under an illumination of 1342 nm, is presented. Consequently, high‐contrast imaging of IR light is obtained on the flexible IRDA arrays. The image information can be then trained and recognized by an artificial neural network for higher image‐recognition efficiency. This work provides a new perspective for developing high‐performance IR imaging systems, and is expected to undoubtedly enlighten future work on artificial intelligence and biorobotic systems.
Realizing Ultrahigh Mechanical Flexibility and >15% Efficiency of Flexible Organic Solar Cells via a “Welding” Flexible Transparent Electrode
Authors: Chen Xiaobin , Xu Guiying , Zeng Guang , Gu Hongwei , Chen Haiyang , Xu Haitao , Yao Huifeng , Li Yaowen , Hou Jianhui , Li Yongfang 
Published: February 2020

AbstractThe power conversion efficiencies (PCEs) of flexible organic solar cells (OSCs) still lag behind those of rigid devices and their mechanical stability is unable to meet the needs of flexible electronics at present due to the lack of a high‐performance flexible transparent electrode (FTE). Here, a so‐called “welding” concept is proposed to design an FTE with tight binding of the upper electrode and the underlying substrate. The upper electrode consisting of solution‐processed Al‐doped ZnO (AZO) and silver nanowire (AgNW) network is well welded by utilizing the capillary force effect and secondary growth of AZO, leading to a reduction of the AgNWs junction site resistance. Meanwhile, the poly(ethylene terephthalate) is modified by embedding the AgNWs, which are then used to link with the AgNWs in the upper hybrid electrode, thus enhancing the adhesion of the electrode to the substrate. By this welding strategy, critical bottleneck issues relating to the FTEs in terms of optoelectronic and mechanical properties are comprehensively addressed. The single‐junction flexible OSCs based on this welded FTE show a high performance, achieving a record high PCE of 15.21%. In addition, the PCEs of the flexible OSCs are less influenced by the device area and display robust bending durability even under extreme test conditions.
A Wearable Toxic Gas‐Monitoring Device Based on Triboelectric Nanogenerator for Self‐Powered Aniline Early Warning
Authors: Chang Junyu , Meng Hu , Li Chunsheng , Gao Jianmei , Chen Shuqin , Hu Qi , Li Hui , Feng Liang 
Published: February 2020

AbstractWith the increasingly serious air pollution and rapid progress in nanotechnology, portable and wearable sensing devices are becoming indispensable to people's lives. The triboelectric nanogenerator (TENG) captures wide attention due to its safe, highly efficient, and environmentally friendly way to drive portable electronics. In this work, by adjusting the doping ratio and optimizing the annealing temperature, a new kind of low‐resistant rGO–In2O3 semiconductor composite is synthesized and innovatively used as TENG electrode. The as‐fabricated rGO‐In2O3‐TENG is used as a monitoring unit and exhibits advantages of excellent linear sensibility (200–1200 ppm), good response (∆I/Ia = 0.26, 600 ppm), and outstanding selectivity toward aniline toxic gas. More importantly, compared with the common room‐temperature semiconductor gas sensor, the self‐powered rGO‐In2O3‐TENG monitoring unit is endowed with much shorter response/recovery time. By combining rGO‐In2O3‐TENG monitoring unit, conversion circuit, and visualization warning lights, a visual wearable aniline early‐warning device is fabricated. The present results provide a novel idea for developing a new type of aniline sensor with self‐powered property of low cost and portability, and may also be extended to the design of other toxic gases‐monitoring system.
Novel Plasmonic Nanocavities for Optical Trapping‐Assisted Biosensing Applications
Authors: Koya Alemayehu Nana , Cunha Joao , Guo Tian‐Long , Toma Andrea , Garoli Denis , Wang Tao , Juodkazis Saulius , Cojoc Dan , Proietti Zaccaria Remo 
Published: February 2020

AbstractPlasmonic nanocavities have proved to confine electromagnetic fields into deep subwavelength volumes, implying their potentials for enhanced optical trapping and sensing of nanoparticles. In this review, the fundamentals and performances of various plasmonic nanocavity geometries are explored with specific emphasis on trapping and detection of small molecules and single nanoparticles. These applications capitalize on the local field intensity, which in turn depends on the size of plasmonic nanocavities. Indeed, properly designed structures provide significant local field intensity and deep trapping potential, leading to manipulation of nano‐objects with low laser power. The relationship between optical trapping‐induced resonance shift and potential energy of plasmonic nanocavity can be analytically expressed in terms of the intercavity field intensity. Within this framework, recent experimental works on trapping and sensing of single nanoparticles and small molecules with plasmonic nanotweezers are discussed. Furthermore, significant consideration is given to conjugation of optical tweezers with Raman spectroscopy, with the aim of developing innovative biosensors. These devices, which take the advantages of plasmonic nanocavities, will be capable of trapping and detecting nanoparticles at the single molecule level.
A Thermochromic Hydrogel for Camouflage and Soft Display
Authors: Wu Tonghao , Yin Tenghao , Hu Xiaocheng , Nian Guodong , Qu Shaoxing , Yang Wei 
Published: February 2020

AbstractRecently, hydrogels with coloration have attracted researchers from various fields, such as camouflage, anti‐counterfeiting, and soft display. However, existing thermochromic hydrogels are limited by their weak color display performance and insufficient sensitivity. Here proposed is a new kind of thermochromic hydrogel which possesses bright colors, fast response time, and reliable results across a long lifespan. This hydrogel is prepared by embedding temperature‐responsive microcapsules containing three components: color developing agent, leuco agent, and solvent. The critical temperature for color changing of the microcapsule is determined by the phase transfer temperature of the solvent. The macroscopic coloration and discoloration of this hydrogel are fast. Soft display and camouflage are proposed for the practical applications in which the thermochromic hydrogel acts as the chameleon phase and the electrothermal filaments as the driving phase. The thermochromic hydrogel can be readily integrated into heat‐sensing devices and smart clothes.
In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity
Authors: Xu Ziyang , Wise Megan C. , Chokkalingam Neethu , Walker Susanne , Tello‐Ruiz Edgar , Elliott Sarah T. C. , Perales‐Puchalt Alfredo , Xiao Peng , Zhu Xizhou , Pumroy Ruth A. , Fisher Paul D. , Schultheis Katherine , Schade Eric , Menis Sergey , Guzman Stacy , Andersen Hanne , Broderick Kate E. , Humeau Laurent M. , Muthumani Kar , Moiseenkova‐Bell Vera , Schief William R. , Weiner David B. , Kulp Daniel W. 
Published: February 2020

AbstractNanotechnologies are considered to be of growing importance to the vaccine field. Through decoration of immunogens on multivalent nanoparticles, designed nanovaccines can elicit improved humoral immunity. However, significant practical and monetary challenges in large‐scale production of nanovaccines have impeded their widespread clinical translation. Here, an alternative approach is illustrated integrating computational protein modeling and adaptive electroporation‐mediated synthetic DNA delivery, thus enabling direct in vivo production of nanovaccines. DNA‐launched nanoparticles are demonstrated displaying an HIV immunogen spontaneously self‐assembled in vivo. DNA‐launched nanovaccines induce stronger humoral responses than their monomeric counterparts in both mice and guinea pigs, and uniquely elicit CD8+ effector T‐cell immunity as compared to recombinant protein nanovaccines. Improvements in vaccine responses recapitulate when DNA‐launched nanovaccines with alternative scaffolds and decorated antigen are designed and evaluated. Finally, evaluation of functional immune responses induced by DLnanovaccines demonstrates that, in comparison to control mice or mice immunized with DNA‐encoded hemagglutinin monomer, mice immunized with a DNA‐launched hemagglutinin nanoparticle vaccine fully survive a lethal influenza challenge, and have substantially lower viral load, weight loss, and influenza‐induced lung pathology. Additional study of these next‐generation in vivo‐produced nanovaccines may offer advantages for immunization against multiple disease targets.
Reduced Graphene Oxide–Based Spectrally Selective Absorber with an Extremely Low Thermal Emittance and High Solar Absorptance
Authors: Liao Qihua , Zhang Panpan , Yao Houze , Cheng Huhu , Li Chun , Qu Liangti 
Published: February 2020

AbstractCarbon‐based black materials exhibit strong solar absorptance (αsolar>0.90), which play key roles in transforming solar energy into available power for solar‐thermal, thermophotovoltaic, thermoelectric, and many other systems. However, because of high thermal emittance (>95%), these carbon‐based materials always cause huge energy loss that hinders the solar‐thermal conversion efficiency tremendously. In this study, a reduced graphene oxide–based spectrally selective absorber (rGO‐SSA) is demonstrated, which possesses a recorded low thermal emittance (≈4%) and high solar absorptance (αsolar≈ 0.92) by easily regulating the reduction level of inner 2D graphene sheets. Compared to conventional carbon‐based black materials, thermal emittance of this rGO‐SSA is largely reduced by ≈95.8% and the cutoff wavelength of rGO‐SSA is broadband‐tunable that can range from 1.1 to 3.2 µm. More importantly, this simply sol‐gel coated rGO‐SSA has high temperature tolerance at 800 °C for 96 h that is hardly achieved by other cermet‐based or photonic‐based SSAs. Based on this rGO‐SSA, ultrafast solar steam escape (0.94 mg cm−2s−1) under concentrated solar irradiance is achieved directly. The insight from this study will provide a new strategy for constructing thermally stable carbon‐based SSAs and greatly facilitate the solar‐thermal practical significance.
Inhibitors of Calcium Oxalate Crystallization for the Treatment of Oxalate Nephropathies
Authors: Kletzmayr Anna , Mulay Shrikant R. , Motrapu Manga , Luo Zhi , Anders Hans‐Joachim , Ivarsson Mattias E. , Leroux Jean‐Christophe 
Published: February 2020

AbstractCalcium oxalate (CaOx) crystal‐induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Although CaOx crystallization inhibitors have been suggested as a therapeutic modality already decades ago, limited progress has been made in the discovery of potent molecules with efficacy in animal disease models. Herein, an image‐based machine learning approach to systematically screen chemically modified myo‐inositol hexakisphosphate (IP6) analogues is utilized, which enables the identification of a highly active divalent inositol phosphate molecule. To date, this is the first molecule shown to completely inhibit the crystallization process in the nanomolar range, reduce crystal–cell interactions, thereby preventing CaOx‐induced transcriptomic changes, and decrease renal CaOx deposition and kidney injury in a mouse model of hyperoxaluria. In conclusion, IP6 analogues based on such a scaffold may represent a new treatment option for CaOx nephropathies.