bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated total homocysteine predicts in-hospital pneumonia and poor functional outcomes in acute ischemic stroke
Authors: You Shoujiang , Wang Lixuan , Du Huaping , Zheng Danni , Zhong Chongke , Wu Qiuyi , Ding Chunqin , Wang Wanhua , Cao Yongjun , Liu Chun-Feng 
Published: February 2020

Abstract
Background

The impact of elevated total homocysteine (tHcy) on functional outcomes and pneumonia after acute ischemic stroke (AIS) is still not well understood.

We investigated the association between tHcy levels upon hospital admission and in-hospital short-term outcomes in AIS patients.

Methods

A total of 2,084 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. We divided patients into 4 groups according to their level of admission tHcy: Q1 (<9.70 umol/L), Q2 (9.70-12.3 umol/L), Q3 (12.3-16.9 umol/L), and Q4 (≥16.9 umol/L). Logistic regression models were used to estimate the effect of tHcy on the short-term outcomes, including in-hospital pneumonia, all cause in-hospital mortality and poor outcome upon discharge (modified Rankin Scale score ≥3) in AIS patients.

Results

During hospitalization, 332 patients (15.9%) had pneumonia, 57 patients (2.7%) died from all causes and 784 (37.6%) patients experienced poor outcome at discharge. The risk of in-hospital pneumonia was significantly higher in patients with highest tHcy level (Q4) compared to those with lowest (Q1) (adjusted odds ratio [OR] 1.55; 95% confidence interval [CI], 1.03-2.33; P -trend =0.019). The highest tHcy level (Q4) was associated with a 3.35-fold and 1.50-fold increase in the risk of in-hospital mortality(adjusted OR 3.35; 95% CI, 1.11–10.13; P -trend =0.015) and poor outcome upon discharge(adjusted OR 1.50; 95% CI, 1.06–2.12; P -trend =0.044) in comparison to Q1 after adjustment for potential covariates including pneumonia. Subgroup analyses further confirmed a significant association between higher tHcy levels and a high risk of short-term outcomes.

Conclusions

Having a high admission tHcy level was independently associated with in-hospital pneumonia, all cause in-hospital mortality and poor outcome upon discharge in AIS patients. Moreover, the association between higher tHcy and poor functional outcome was not modified by pneumonia.
A benchmarked in-silico driven pipeline capable of complete trifecta protein analysis
Authors: Perera Duwage Dahampriya Baladeva Deshan , Peiris Dinithi 
Published: February 2020

Abstract
Background Current in-silico based proteomics requires the prediction, validation and functional analysis of a modelled protein. The main drawback in this protocol is the lack of a singular protocol that utilizes a proper set of benchmarked open science tools to accurately predict a protein’s structure and function. Results The present study aims to utilize a series of openly available computational tools to formulate a complete pipeline capable of analyzing a novel protein’s amino acid sequence, reveal its phylogenetic relationships and conserved residues. The resultant data would then be utilized in the formulation of the protein’s tertiary structure followed by functional analysis through virtual screening. This novel protocol was benchmarked utilizing the Cystatin C protein obtained from Danio rerio and the AChE proteins of Homo sapiens and Rattus norvegicus. Conclusion The resultant pipeline utilizes freely available in-silico tools capable of complete protein analysis including a novel protein’s functional analysis. The methodology has been proven and the tools have been benchmarked as the most suited for complete trifecta protein analysis.
An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance
Authors: Tang Yu-Qing , Ye Qian , Huang He , Zheng Wei-Yi 
Published: February 2020

:
Malaria is one of the three most deadly infectious diseases in the world and
seriously endangers human health and life. To reduce the public health burden of this
disease, scientists have focused on the discovery and development of effective
antimalarial drugs, from quinine and chloroquine to antifolates and artemisinin and its
derivatives, which all play a profound role in the treatment of malaria. However, drugresistant
strains of Plasmodium falciparum have emerged due to frequent use of
antimalarials and have become increasingly resistant to existing antimalarial drugs,
causing disastrous consequences in the world. In particular, artemisinin resistance is of
greatest concern which was reported in 2008. Resistance to artenisinins has been a
major obstacle for malaria control, and current efforts to curb artemisinin resistance have
not been successful. Based on the current situation, it is urgent to develop more effective
new antimalarials with distinct targets from conventional antimalarials in the world, which
could facilitate to minimize the phenomenon of drug resistance. This review aims to
summarize different kinds of antimalarial therapeutic efficacy, mechanisms of action and
resistance, and proposes new solutions aiming towards further improvement of malaria
elimination.
Fabrication, Optimization and Characterization of Paclitaxel and Spirulina Loaded Nanoparticles for Enhanced Oral Bioavailability
Authors: Nair Keerthi G.S. , Ravikumar Yamuna , Sukumaran Sathesh Kumar , Velmurugan Ramaiyan 
Published: February 2020

Background:
Paclitaxel and spirulina when administered as nanoparticles, are potentially
useful.

Methods:
Nanoformualtions of Paclitaxel and Spirulina for gastric cancer were formulated and optimized
with Central composite rotatable design (CCRD) using Response surface methodology
(RSM).

Results:
The significant findings were the optimal formulation of polymer concentration 48 mg,
surfactant concentration 45% and stirring time of 60 min gave rise to the EE of (98.12 ± 1.3)%, DL
of (15.61 ± 1.9)%, mean diameter of (198 ± 4.7) nm. The release of paclitaxel and spirulina from the
nanoparticle matrix at pH 6.2 was almost 45% and 80% in 5 h and 120 h, respectively. The oral
bioavailability for the paclitaxel spirulina nanoparticles developed is 24.0% at 10 mg/kg paclitaxel
dose, which is 10 times of that for oral pure paclitaxel. The results suggest that RSM-CCRD could
efficiently be applied for the modeling of nanoparticles. The paclitaxel and spirulina release rate in
the tumor cells may be higher than in normal cells. Paclitaxel spirulina nanoparticle formulation may
have higher bioavailability and longer sustainable therapeutic time as compared with pure paclitaxel.

Conclusion:
Paclitaxel-Spirulina co-loaded nanoparticles could be effectively useful in gastric cancer
as chemotherapeutic formulation.
Feasibility and Utility of mHealth for the Remote Monitoring of Parkinson Disease: Ancillary Study of the PD_manager Randomized Controlled Trial
Authors: Gatsios Dimitris , Antonini Angelo , Gentile Giovanni , Marcante Andrea , Pellicano Clelia , Macchiusi Lucia , Assogna Francesca , Spalletta Gianfranco , Gage Heather , Touray Morro , Timotijevic Lada , Hodgkins Charo , Chondrogiorgi Maria , Rigas George , Fotiadis Dimitrios I , Konitsiotis Spyridon 
Published: February 2020

Background
Mobile health, predominantly wearable technology and mobile apps, have been considered in Parkinson disease to provide valuable ecological data between face-to-face visits and improve monitoring of motor symptoms remotely.

Objective
We explored the feasibility of using a technology-based mHealth platform comprising a smartphone in combination with a smartwatch and a pair of smart insoles, described in this study as the PD_manager system, to collect clinically meaningful data. We also explored outcomes and disease-related factors that are important determinants to establish feasibility. Finally, we further validated a tremor evaluation method with data collected while patients performed their daily activities.

Methods
PD_manager trial was an open-label parallel group randomized study.The mHealth platform consists of a wristband, a pair of sensor insoles, a smartphone (with dedicated mobile Android apps) and a knowledge platform serving as the cloud backend. Compliance was assessed with statistical analysis and the factors affecting it using appropriate regression analysis. The correlation of the scores of our previous algorithm for tremor evaluation and the respective Unified Parkinson’s Disease Rating Scale estimations by clinicians were explored.

Results
Of the 75 study participants, 65 (87%) completed the protocol. They used the PD_manager system for a median 11.57 (SD 3.15) days. Regression analysis suggests that the main factor associated with high use was caregivers’ burden. Motor Aspects of Experiences of Daily Living and patients’ self-rated health status also influence the system’s use. Our algorithm provided clinically meaningful data for the detection and evaluation of tremor.

Conclusions
We found that PD patients, regardless of their demographics and disease characteristics, used the system for 11 to 14 days. The study further supports that mHealth can be an effective tool for the ecologically valid, passive, unobtrusive monitoring and evaluation of symptoms. Future studies will be required to demonstrate that an mHealth platform can improve disease management and care.

Trial Registration
ISRCTN Registry ISRCTN17396879; http://www.isrctn.com/ISRCTN17396879

International Registered Report Identifier (IRRID)
RR2-10.1186/s13063-018-2767-4
Metrics for Outpatient Portal Use Based on Log File Analysis: Algorithm Development
Authors: Di Tosto Gennaro , McAlearney Ann Scheck , Fareed Naleef , Huerta Timothy R 
Published: February 2020

Background
Web-based outpatient portals help patients engage in the management of their health by allowing them to access their medical information, schedule appointments, track their medications, and communicate with their physicians and care team members. Initial studies have shown that portal adoption positively affects health outcomes; however, early studies typically relied on survey data. Using data from health portal applications, we conducted systematic assessments of patients’ use of an outpatient portal to examine how patients engage with the tool.

Objective
This study aimed to document the functionality of an outpatient portal in the context of outpatient care by mining portal usage data and to provide insights into how patients use this tool.

Methods
Using audit log files from the outpatient portal associated with the electronic health record system implemented at a large multihospital academic medical center, we investigated the behavioral traces of a study population of 2607 patients who used the portal between July 2015 and February 2019. Patient portal use was defined as having an active account and having accessed any portal function more than once during the study time frame.

Results
Through our analysis of audit log file data of the number and type of user interactions, we developed a taxonomy of functions and actions and computed analytic metrics, including frequency and comprehensiveness of use. We additionally documented the computational steps required to diagnose artifactual data and arrive at valid usage metrics. Of the 2607 patients in our sample, 2511 were active users of the patients portal where the median number of sessions was 94 (IQR 207). Function use was comprehensive at the patient level, while each session was instead limited to the use of one specific function. Only 17.45% (78,787/451,762) of the sessions were linked to activities involving more than one portal function.

Conclusions
In discussing the full methodological choices made in our analysis, we hope to promote the replicability of our study at other institutions and contribute to the establishment of best practices that can facilitate the adoption of behavioral metrics that enable the measurement of patient engagement based on the outpatient portal use.
Расширения Инабы полных полей характеристики 0
Authors: Востоков Сергей Владимирович , Жуков Игорь Борисович , Иванова Ольга Юрьевна 
Published: February 2020

В статье изучаются p--расширения полных дискретно нормированных полей смешанной характеристики, где p-характеристика поля вычетов рассматриваемого поля. Известно, что любое вполне разветвленное расширение Галуа степени p-с немаксимальным скачком ветвления может быть задано уравнением Артина-Шрайера; при этом ограничение сверху на скачок ветвления соответствует ограничению снизу на нормирование правой части уравнения. Задача построения расширений с заданной группой Галуа произвольного конечного порядка не решена. В работах Инабы рассматривались p-расширения полей характеристики p, заданные матричным уравнением $$X^{(p)}=AX$$, которое мы здесь называем уравнением Инабы. В этом уравнении $$X^{(p)}$$ обозначает матрицу, полученную возведением каждого элемента квадратной матрицы X в степень p, а - некоторая унипотентная матрица A над данным полем. Такое уравнение задает последовательность расширений полей, каждое из которых задано уравнением Артина-Шрайера. Было доказано, что любое уравнение Инабы задает расширение Галуа, и обратно, любое конечное p-расширение Галуа задается уравнением такого вида. В настоящей работе для полей смешанной характеристики доказано, что расширение, задаваемое уравнением Инабы, является расширением Галуа, если нормирования элементов матрицы удовлетворяют некоторым оценкам снизу, т.е. если скачки промежуточных расширений степени p достаточно малы. Данная конструкция может применяться при решении задачи погружения расширений полей. Уравнение Инабы задает последовательность расширений полей, полученную последовательным присоединением элементов диагоналей матрицы. Это означает, что, если расширение L/K задано уравнением Инабы, и матрица A выбрана так, что на диагоналях с большими номерами записаны нули, то можно получать расширения, содержащие L/K, заменяя нули другими элементами. В работе доказано, что любое нециклическое расширение степени $$p^2$$ с достаточно маленькими скачками можно погрузить в расширение с группой Галуа, изоморфнной группе унипотентных матриц $$3\times 3$$ над полем из p элементов. В конце статьи сформулирован ряд открытых вопросов, при исследовании которых, возможно, окажется полезной данная конструкция.
Стохастические тренды на основе нечеткой математики
Authors: Агаян Сергей Мартикович , Богоутдинов Шамиль Рафекович , Камаев Дмитрий Альфредович , Добровольский Михаил Николаевич 
Published: February 2020

В настоящее время существует ряд способов определения трендов и экстремумов на стохастических временных рядах, что неудивительно, поскольку тренды временного ряда являются фундаментальной характеристикой динамики процесса, стоящего за ним. Реальные стохастические тренды совсем не похожи на идеальные математические, посколько в них случаются сбои. Это не смущает исследователя, изначально обладающего адаптивным восприятием фундаментальных свойств предельности, непрерывности, связности, тренда и т. д. Он поймет, когда нарушение несущественно и тренд продолжается, а когда нарушение прерывает тренд.В настоящей работе предлагается новый подход к распознаванию стохастических трендов, основанный на математической конструкции регрессионных производных для конечного временного ряда. Тренды ищутся с помощью производной по сценарию классического математического анализа.
ANALISA PERFORMANSI COMBAT BTS ROOFTOP PADA JALUR TRANSMISI FIBER OPTIK METRO E
Authors: Budiyanto Setiyo , Diana Hanifah 
Published: February 2020

Pada saat ini teknologi serat optik menjadi media transmisi yang layak diperhitungkan penggunaannya dalam penyediaan akses karena memiliki kapabilitas dan kapasitas yang paling tinggi dibandingkan dengan media transmisi lainnya. Dalam menyediakan akses informasi dengan volume bandwidth yang besar, serat optik memiliki prospek yang menjanjikan. Akses microwave berbasis sistem multiplexing saat ini mulai digantikan perannya dengan akses serat optik berbasis Internet Protocol (IP) yang disebut dengan Metro Ethernet. Aplikasi Metro Ethernet untuk akses ke menara Base Station Transceiver (BTS) dan Radio Network Connection (RNC) operator selular merupakan salah satu tawaran yang diberikan oleh jaringan Metro Ethernet saat ini. Penggunaan Ip clock sangat dibutuhkan pada Base Transceiver Station (BTS) untuk sinkronisasi jaringan sebagai jam global yang berasal dari jam GPS diakuisisi oleh sejumlah BTS. IP clock didistribusikan ke pengendali serta acuan berbagai jaringan, dan dari sana ke jaringan perangkat akses, sehingga terwujud sinkronisasi jaringan komunikasi konvergensi antara BTS ke RNC yang melewati Metro E dengan media transmisi Fiber Optik. Pada penelitian ini, penulis menganalisa permasalahan link BTS dengan IP Clock sebagai alarm monitoring dan kaitannya dengan kesesuaian V-lan pada jaringan tersebut. Perhitungan dan analisa Quality of Service (QOS) dari penggunaan fiber optik sebagai media transmisi yang melewati Metro E pada link antara BTS ke RNC, dimana parameter-parameter pandukung yang digunakan seperti Delay, Jitter, Packet Loss, untuk memudahkan dalam mengetahui performansinya.Kata Kunci : Fiber Optik, Metro E, BTS, IP Clock, QoS
ANALISA PERBANDINGAN WIRELESSLAN DAN WIRELAN
Authors: Djamal Hidajanto 
Published: February 2020

Jaringan data dalam satu institusi pemerintah ataupun swasta terutama satu korporat, sudah merupakan kebutuhan manajerial. Dengan ketersediaan jaringan data tersebut, maka keputusan-keputusan manajemen akan jauh lebih cepat daripada hanya ditunjang dengan satu sistem server yang stand alone. Satu contoh misalnya dalam bidang layanan kependudukan, dimana data jumlah penduduk dalam satu daerah harus dapat diakses, baik oleh seorang Kepala Daerah, Kepala Dinas Kependudukan maupun oleh pelaksana layanan KTP secara online. Dapat dibayangkan bagaimana bila server tersebut hanya stand alone dan berada pada pelaksana layanan KTP saja.Dengan jaringan yang makin meluas, sistem wireline akan menjumpai beberapa kesulitan instalasinya, baik segi estetika pengaturan ruangan maupun pemeliharaan kerusakan jaringan yang terjadi, serta kendala jaringan yang terpisah bangunan gedungnya. Solusinya adalah penggantian sistem tersebut menjadi wireless. Dengan sistem wireless, antara pusat pemerintahan (gedung utama) dengan unit kerja pemerintahan yang terpisah gedung maupun lokasi, dapat terjaring dalam sistem wireless tersebut dengan mudah. Disamping itu dengan sistem wireless, host (lap top) dapat diatur berpindah pindah, untuk satu keperluan rapat misalnya, dengan leluasa.Penelitian ini akan membahas teknologi akses Internet melalui sistem WLAN (Wireless LAN) atau WiFi (Wireless Fidelity), dimana user dimungkinkan untuk bergerak atau mobile. Persoalan yang akan dibahas terutama menyangkut pada proses handover antara access point satu dengan access point berikutnya.Kata kunci: Wireless, LAN, access
SISTEM KOREKSI OTOMATIS PADA MESIN PACKAGING DENGAN PENGENDALI PLC
Authors: Saputra Andrial , Rahman Alwin Wahyu Fadhlir 
Published: February 2020

Salah satu kecacatan produk dalam kemasan pouch apabila produk tersebut ditemukan overlap. Overlap pada produk sabun refill (isi ulang) merupakan salah satu kecacatan produk yang dapat menyebabkan minat konsumen menurun. Sistem Autocorrection (Pengoreksi-Otomatis) merupakan sistem kendali berbasis PLC (Programmable Logic Controller) yang dirancang untuk mengatasi overlap pada produk pouch. Sensor photo electric amplifier ditanamkan pada sistem ini yang berfungsi sebagai trigger input ke PLC (Programmable Logic Controller) sekaligus pendeteksi overlap yang kemudian sinyal input dari sensor tersebut diolah oleh PLC (Programmable Logic Controller). Output yang dihasilkan berupa gerakan pada sidelay motor (actuator dengan motor AC sebagai penggeraknya) untuk bergeser ke arah kiri atau ke arah kanan tergantung salah satu sensor aktif terlebih dahulu.
Finite Element Modeling and Critical Plane Analysis of a Cut-and-Chip Experiment for Rubber
Authors: Robertson Christopher G. , Suter Jesse D. , Bauman Mark A. , Stoček Radek , Mars William V. 
Published: February 2020

ABSTRACT
Rubber surfaces exposed to concentrated, sliding impacts carry large normal and shearing stresses that can cause damage and the eventual removal of material from the surface. Understanding this cut-and-chip (CC) effect in rubber is key to developing improved tread compounds for tires used in off-road or poor road conditions. To better understand the mechanics involved in the CC process, an analysis was performed of an experiment conducted on a recently introduced device, the Instrumented Chip and Cut Analyzer (ICCA), which repetitively impacts a rigid indenter against a rotating solid rubber wheel. The impact process is carefully controlled and measured on this lab instrument, so that the contact time, normal force, and shear force are all known. The numerical evaluation includes Abaqus finite element analysis (FEA) to determine the stress and strain fields during impact. The FEA results are combined with rubber fracture mechanics characteristics of the material as inputs to the Endurica CL elastomer fatigue solver, which employs critical plane analysis to determine the fatigue response of the specimen surface. The modeling inputs are experimentally determined hyperelastic stress-strain parameters, crack growth rate laws, and crack precursor sizes for carbon black–filled compounds wherein the type of elastomer is varied in order to compare natural rubber (NR), butadiene rubber (BR), and styrene-butadiene rubber (SBR). At the lower impact force, the simulation results were consistent with the relative CC resistances of NR, BR, and SBR measured using the ICCA, which followed the order BR &gt; NR &gt; SBR. Impact-induced temperature increases need to be considered in the fatigue analysis of the higher impact force to provide lifetime predictions that match the experimental CC resistance ranking of NR &gt; SBR &gt; BR.
Authors: Nurdin Nurdin , Ridwan Muhammad , Fitriningsih Fitriningsih 
Published: February 2020

Penelitian ini dilatar belakangi oleh berkembangnya teknologi dan informasi yang sangat cepat salah satunya adalah media sosial, salah satu media sosial yang paling populer adalah instagram. Instagram adalah media sosial dengan sistem pengolahan foto dan video serta perolehan informasi yang lebih praktis, kelebihan kelebihan yang disajikan media sosial instagram mampu meraih pengguna terbanyak dari media sosial lain tak terkecuali mahasiswa. Konten-konten yang ada di dalam instagram tidak hanya sekedar informasi dan hiburan, instagram menawarkan berita tentang keislaman yang dapat mempengaruhi penggunanya termasuk mahasiswa. Adapun yang menjadi pertanyaan penelitian ini adalah apakah ada pengaruh dakwah di instagram terhadap perilaku keagamaan mahasiswa di perguruan tinggi? Kemudian apakah dakwah di instagram berpengaruh terhadap perilaku keagamaan mahasiswa diperguruan tinggi? Penelitian ini adalah penelitian kuantitatif, dengan metode pengumpulan data melalui observasi, wawancara, dan penyebaran angket. Metode analisis data yang digunakan adalah uji normalitas, uji hipotesis dan uji koefisien regresi linear sederhana yang kemudian pengolahan datanya menggunakan aplikasi SPSS 16 for windows. Populasi dalam penelitian ini adalah seluruh mahasiswa komunikasi dan penyiaran islam dari angkatan 2015 sampai angkatan 2018. Teknik pengambilan sampel yang digunakan adalah teknik purposive sampling, sebanyak 60 orang dengan menentukan pengguna aktif di instagram. Hasil olahan statistik yang dibantu dengan program SPSS 16 for window, yang menunjukkan bahwa dakwah di instagram (X) berpengaruh signifikan terhadap perilaku keagamaan (Y)mahasiswa komunikasi penyiaran islam dengan nilai sig lebih kecil dari nilai (α) yaitu 0.000 < 0.05 dengan besaran pengaruhnya adalah sebesar 0.526 atau 52.6%, sedangkan sisanya 47,6% dijelaskan oleh variabel independen yang lain yang tidak termasuk dalam penelitian ini.