bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Diaphragmatic Breathing on the Pathophysiology and Treatment of Upright Gastroesophageal Reflux: A Randomized Controlled Trial
Authors: Halland Magnus , Bharucha Adil E. , Crowell Michael D. , Ravi Karthik , Katzka David A. 
Published: October 2020

INTRODUCTION:
Uncontrolled results suggest that diaphragmatic breathing (DB) is effective in gastroesophageal reflux disease (GERD) but the mechanism of action and rigor of proof is lacking. This study aimed to determine the effects of DB on reflux, lower esophageal sphincter (LES), and gastric pressures in patients with upright GERD and controls.

METHODS:
Adult patients with pH proven upright GERD were studied. During a high-resolution impedance manometry, study patients received a standardized pH neutral refluxogenic meal followed by LES challenge maneuvers (Valsalva and abdominal hollowing) while randomized to DB or sham. After that, patients underwent 48 hours of pH-impedance monitoring, with 50% randomization to postprandial DB during the second day.

RESULTS:
On examining 23 patients and 10 controls, postprandial gastric pressure was found to be significantly higher in patients compared with that in controls (12 vs 7 mm Hg, P = 0.018). Valsalva maneuver produced reflux in 65.2% of patients compared with 44.4% of controls (P = 0.035). LES increased during the inspiratory portion of DB (42.2 vs 23.1 mm Hg, P < 0.001) in patients and healthy persons. Postprandial DB reduced the number of postprandial reflux events in patients (0.36 vs 2.60, P < 0.001) and healthy subjects (0.00 vs 1.75, P < 0.001) compared with observation. During 48-hour ambulatory study, DB reduced the reflux episodes on day 2 compared with observation on day 1 in both the patient and control groups (P = 0.049). In patients, comparing DB with sham, total acid exposure on day 2 was not different (10.2 ± 7.9 vs 9.4 ± 6.2, P = 0.804). In patients randomized to DB, esophageal acid exposure in a 2-hour window after the standardized meal on day 1 vs day 2 reduced from 11.8% ±6.4 to 5.2% ± 5.1, P = 0.015.

DISCUSSION:
In patients with upright GERD, DB reduces the number of postprandial reflux events pressure by increasing the difference between LES and gastric pressure. These data further encourage studying DB as therapy for GERD.
Fendrix vs Engerix-B for Primo-Vaccination Against Hepatitis B Infection in Patients With Inflammatory Bowel Disease: A Randomized Clinical Trial
Authors: Chaparro María , Gordillo Jordi , Domènech Eugeni , Esteve Maria , Barreiro-de Acosta Manuel , Villoria Albert , Iglesias-Flores Eva , Blasi Mercedes , Naves Juan E. , Benítez Olga , Nieto Laura , Calvet Xavier , García-Sánchez Valle , Villagrasa José Ramón , Marin Alicia C. , Donday María G. , Abad-Santos Francisco , Gisbert Javier P. 
Published: October 2020

INTRODUCTION:
To compare Engerix-B and Fendrix hepatitis B virus for primo vaccination in inflammatory bowel disease (IBD).

METHODS:
Patients with IBD were randomized 1:1 to receive Engerix-B double dose or Fendrix single dose at months 0, 1, 2, and 6. Anti-HBs titers were measured 2 months after the third and fourth doses. Response to vaccination was defined as anti-HBs ≥100 UI/L. Anti-HBs titers were measured 2 months after the third and fourth doses and again at 6 and 12 months after the fourth dose.

RESULTS:
A total of 173 patients were randomized (54% received Engerix-B and 46% Fendrix). Overall, 45% of patients responded (anti-HBs ≥100 IU/L) after 3 doses and 71% after the fourth dose. The response rate after the fourth dose was 75% with Fendrix vs 68% with Engerix-B (P = 0.3). Older age and treatment with steroids, immunomodulators, or anti–tumor necrosis factor were associated with a lower probability of response. However, the type of vaccine was not associated with the response. Anti-HBs titer negativization occurred in 13% of patients after 6 months and 20% after 12 months. Anti-HBs ≥100 IU/L after vaccination was the only factor associated with maintaining anti-HBs titers during follow-up.

DISCUSSION:
We could not demonstrate a higher response rate of Fendrix (single dose) over Engerix-B (double dose). A 4-dose schedule is more effective than a 3-dose regimen. Older age and treatment with immunomodulators or anti–tumor necrosis factors impaired the success. A high proportion of IBD patients with protective anti-HBs titers after vaccination loose them over time. The risk of losing protective anti-HBs titers is increased in patients achieving anti-HBs <100 IU/L after the vaccination.
Symptom Stability in Rome IV vs Rome III Irritable Bowel Syndrome
Authors: Barberio Brigida , Houghton Lesley A. , Yiannakou Yan , Savarino Edoardo V. , Black Christopher J. , Ford Alexander C. 
Published: October 2020

INTRODUCTION:
Irritable bowel syndrome (IBS) is a chronic functional bowel disorder, which follows a relapsing and remitting course. Little is known about how evolving definitions of IBS or treatment for the condition affect symptom stability. We conducted a 12-month longitudinal follow-up study of individuals who self-identified as having IBS to examine these issues.

METHODS:
We collected demographic, gastrointestinal symptom, mood, and psychological health data at baseline, and gastrointestinal symptom data at 12 months, from adults who self-identified as having IBS, registered with 3 organizations providing services to people with IBS. We applied the Rome III and Rome IV criteria simultaneously at baseline and 12 months and subtyped participants according to predominant stool form or frequency. We examined stability of a diagnosis of IBS, and stability of IBS subtype, for the Rome IV and III criteria separately and examined the effect of commencing new therapy on fluctuation of symptoms.

RESULTS:
Of 1,375 individuals recruited at baseline, 784 (57.0%) provided data at 12 months. Of these, 452 met the Rome IV criteria for IBS at baseline, of whom 133 (29.4%) fluctuated to another functional bowel disorder at 12 months. In the remaining 319 (70.6%) who still met the Rome IV criteria for IBS, IBS subtype changed in 101 (31.7%) subjects, with IBS with mixed bowel habit (IBS-M) the least stable. Commencing a new treatment for IBS did not affect symptom stability. Among 631 who met the Rome III criteria at baseline responding at 12 months, 104 (16.5%) fluctuated to another functional bowel disorder. In the 527 (83.5%) who still met the Rome III criteria for IBS, IBS subtype fluctuated in 129 (24.5%), with IBS-M the most stable subtype. Again, commencing a new treatment for IBS did not affect symptom stability.

DISCUSSION:
Fluctuation between functional bowel disorders and predominant stool subtype is common in people with IBS and does not appear to be influenced solely by treatment. Rome IV IBS appears less stable than Rome III IBS.
Risk of Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Patients With Achalasia: A Long-Term Prospective Cohort Study in Italy
Authors: Zagari Rocco Maurizio , Marasco Giovanni , Tassi Valentina , Ferretti Stefano , Lugaresi Marialuisa , Fortunato Francesca , Bazzoli Franco , Mattioli Sandro 
Published: October 2020

INTRODUCTION:
Epidemiological studies assessing relative risk and incidence rate of esophageal cancer in patients with achalasia are scarce. We performed a long-term prospective cohort study to evaluate the risk of both squamous cell carcinoma and adenocarcinoma of the esophagus in these patients.

METHODS:
Between 1973 and 2018, patients with primary achalasia were followed by the same protocol including upper endoscopy with esophageal biopsies. Standardized incidence ratios (SIRs) with 95% confidence interval (CI) were used to estimate the relative risk of esophageal cancer in patients with achalasia compared with the sex- and age-matched general population.

RESULTS:
A cohort of 566 patients with achalasia (46% men, mean age at diagnosis: 48.1 years) was followed for a mean of 15.5 years since the diagnosis of achalasia. Overall, 20 patients (15 men) developed esophageal cancer: 15 squamous cell carcinoma and 5 adenocarcinoma. The risk of esophageal cancer was significantly greater than the general population (SIR 104.2, 95% CI 63.7–161), and this for both squamous cell carcinoma (SIR 126.9, 95% CI 71.0–209.3) and adenocarcinoma (SIR 110.2, 95% CI 35.8–257.2). The excess risk was higher in men than women. Annual incidence rate of esophageal cancer was only 0.24% and was higher for squamous cell carcinoma (0.18%) than adenocarcinoma (0.06%).

DISCUSSION:
Patients with achalasia have an excess risk of developing both squamous cell carcinoma and adenocarcinoma of the esophagus; however, this prospective cohort study confirms that the annual incidence of esophageal cancer is rather low. These findings may have implications for endoscopic surveillance of patients with achalasia.
Genetic Analysis of Walnut (Juglans regia L.) Pellicle Pigment Variation Through a Novel, High-Throughput Phenotyping Platform
Authors: Sideli Gina M , McAtee Peter , Marrano Annarita , Allen Brian J , Brown Patrick J , Butterfield Timothy S , Dandekar Abhaya M , Leslie Charles A , Neale David B 
Published: October 2020

Abstract
Walnut pellicle color is a key quality attribute that drives consumer preference and walnut sales. For the first time a high-throughput, computer vision-based phenotyping platform using a custom algorithm to quantitatively score each walnut pellicle in L* a* b* color space was deployed at large-scale. This was compared to traditional qualitative scoring by eye and was used to dissect the genetics of pellicle pigmentation. Progeny from both a bi-parental population of 168 trees (‘Chandler’ × ‘Idaho’) and a genome-wide association (GWAS) with 528 trees of the UC Davis Walnut Improvement Program were analyzed. Color phenotypes were found to have overlapping regions in the ‘Chandler’ genetic map on Chr01 suggesting complex genetic control. In the GWAS population, multiple, small effect QTL across Chr01, Chr07, Chr08, Chr09, Chr10, Chr12 and Chr13 were discovered. Marker trait associations were co-localized with QTL mapping on Chr01, Chr10, Chr14, and Chr16. Putative candidate genes controlling walnut pellicle pigmentation were postulated.
Clinical symptoms, endoscopic imaging and stroboscopic imaging in patients with laryngeal fungal infection : An evaluation in 48 patients
Authors: Trang Pham Thi Linh , Thi Dao Dinh , Son Nguyen Tuan 
Published: October 2020

Introduction: Aspergillus fumigatus and Candida albicans are the most common pathogenic fungi found in Vietnam. Fungal laryngitis has yet to be thoroughly investigated due to the rarity of the disease. This study aimed to describe the clinical, endoscopic and stroboscopic imaging characteristics among patients with fungal laryngitis.
Methods: A cross-sectional study was performed on 48 patients diagnosed with fungal laryngitis at the Endoscopy Department of the National Ear- Nose-Throat Hospital of Vietnam from August 2019 to March 2020. Clinical, endoscopic and stroboscopic imaging characteristics among patients with fungal laryngitis were reported.
Results: The rate of fungal laryngitis was higher in men compared to women (men/women ratio: 2.2/1). All patients had dysphonia (100%), while other symptoms included coughing (64.6%) and foreign body sensation (50%). In laryngeal endoscopy, fungal pseudo-membrane was thick with white layer (56.3%) on the vocal cords (100%). In laryngeal stroboscopy, less than half of patients had mucosal wave formation (47.9%). The success rate of fungal culture identification was not high (41.7%), with Aspergillus fumigatus as the main pathogenic fungus (90%).
Conclusions: Patients with fungal laryngitis in our setting developed prolonged dysphonia. By using endoscopic imaging and stroboscopic imaging, layers of fungal pseudo-membrane on the vocal cords could be observed and extracted for diagnosis.
Trends in scientific research on precision farming in agriculture using science mapping method
Authors: Maloku Donika , Balogh Péter , Bai Attila , Gabnai Zoltán , Lengyel Péter 
Published: October 2020

AbstractThe article highlights the worldwide dissemination of precision agriculture scientific researches published from the period of 1996–2018, data gathered in the Scopus citation database, using the science mapping method. The findings show that there is a constant rise in the number of publications in precision agriculture. The USA is not only leading in the adoption of precision agriculture technologies but also in the publication of papers, accompanied by China placed in second place. The most frequent keywords highlighted the main topics authors concentrated on more, and the national affiliation of most cited papers was the USA. The main prominence and contributions of the results present scientific research trends in precision agriculture in the last two decades, and demonstrate the main countries, authors and organizations who have contributed, and were more productive in this area.
Mechanical properties and microstructural evaluation of heat-treated aluminum alloy using formulated bio-quenchants
Authors: Adekunle Adebayo Surajudeen , Adeleke Adekunle Akanni , Ikubanni Peter Pelumi , Omoniyi Peter Olorunleke , Gbadamosi Tajudeen Adelani , Odusote Jamiu Kolawole 
Published: October 2020

AbstractHeat treatment industries require various quenching media to improve the properties of the materials to be quenched. Petroleum based mineral (PBM) oil, a non-biodegradable oil, is popular amongst others quenchants in heat treatment processes. Recently, biodegradable oils mostly in their raw, unblended and unbleached forms have been employed for quenching of various engineering materials. Therefore, the present study examined the effects of some selected bio-quenchants in blended raw (BR) and blended bleached (BB) forms on the mechanical properties and microstructure of solution heat treated aluminum (Al)-alloy. Edible vegetable oil (70% by volume) was blended with 30% by volume of jatropha oil to form the bio-quenchant oils. Another set of bio-quenchants were formed by bleaching the raw oils before mixing so as to reduce the oxidation level and contaminations in the oil. The Al-alloy is solution heat treated at 500 °C and soaked for 15 min in an electric muffle furnace before quenching in the various established bio-quenchants. Results showed that samples treated in blended raw melon (BRM) oil have higher tensile strength of 151.76 N/mm2 while samples quenched in blended bleached melon (BBM) oil have higher hardness value of 61.00 HRC. In accordance to the results obtained the bio-quenchants were found to be effective replacement to the PBM oil.
The role of sports and well-being programmes in choosing workplaces in the future
Authors: Balogh Renátó , Bába Éva Bácsné 
Published: October 2020

AbstractDue to recent changes in the labour market, recruitment and retaining employees have become more important than ever. Research dealing with the appearance of new generations in the labour market has found that they are less loyal to their employers, have high demands, and the key factors that they consider when choosing a job are salary, career opportunities, working environment, and work-life balance. As numerous studies in recent years have proved the importance of a healthy lifestyle in the context of labour, the question has arisen whether opportunities for sport participation and services supporting the well-being of employees have an influence on young people when they are seeking employment. We carried out an online survey to find out what students of the University of Debrecen think about the issue. The results were in line with the findings of previous studies, that is, young people look for high salaries, good working conditions, work-life balance and career opportunities when choosing a job. However, respondents did not identify sports opportunities and well-being benefits as major factors Yet, we found significant differences between different groups in terms of preference of particular factors, depending on sex, marital status, and whether someone does physical exercises regularly, and whether someone works while attending a university course or not.
Desire thinking as a predictor of compulsive sexual behaviour in adolescents: Evidence from a cross-cultural validation of the Hebrew version of the Desire Thinking Questionnaire
Authors: Efrati Yaniv , Kolubinski Daniel C. , Caselli Gabriele , Spada Marcantonio M. 
Published: October 2020

AbstractBackgroundDesire thinking is a voluntary cognitive process that involves the perseverative focus on memories, images and information related to a desired target. The aim of the present study was to validate the Hebrew version of the Desire Thinking Questionnaire (DTQ; Caselli & Spada, 2011) in a sample of adolescents and to investigate its relationship with measures of thought suppression, impulsivity and individual-based compulsive sexual behaviour.MethodsIn Study 1, a convenience sample of 718 adolescents completed the newly translated Desire Thinking Questionnaire in Hebrew (DTQ-H) and results were subjected to an Exploratory Factor Analysis (EFA). In Study 2, a convenience sample of 379 adolescents completed a battery of questionnaires including the DTQ-H. A Confirmatory Factors Analysis was performed on the DTQ-H and validity was ascertained by correlating with other measures.ResultsIn Study 1, a 9-item two-factor structure was identified. A 6-item two-factor structure was confirmed in Study 2. Results also indicated that the DTQ-H has acceptable levels of reliability, and good concurrent and incremental validity in predicting compulsive sexual behaviour.ConclusionsThe 6-item DTQ-H appears to be a reliable and valid measure of desire thinking and may be used also on adolescents – an understudied population.
Predictive utility of the brief Screener for Substance and Behavioral Addictions for identifying self-attributed problems
Authors: Schluter Magdalen G. , Hodgins David C. , Konkolÿ Thege Barna , Wild T. Cameron 
Published: October 2020

AbstractBackground and aimsThe Brief Screener for Substance and Behavioral Addictions (SSBAs) was developed to assess a common addiction construct across four substances (alcohol, tobacco, cannabis, and cocaine), and six behaviors (gambling, shopping, videogaming, eating, sexual activity, and working) using a lay epidemiology perspective. This paper extends our previous work by examining the predictive utility of the SSBA to identify self-attributed addiction problems.MethodParticipants (N = 6,000) were recruited in Canada using quota sampling methods. Receiver Operating Characteristics (ROCs) analyses were conducted, and thresholds established for each target behavior's subscale to predict self-attributed problems with these substances and behaviors. For each substance and behavior, regression models compared overall classification accuracy and model fit when lay epidemiologic indicators assessed using the SSBA were compared with validated screening measures to predict selfattributed problems.ResultsROC analyses indicted moderate to high diagnostic accuracy (Area under the curves (AUCs) 0.73–0.94) across SSBA subscales. Thresholds for identifying self-attributed problems were 3 for six of the subscales (alcohol, tobacco, cannabis, cocaine, shopping, and gaming), and 2 for the remaining four behaviors (gambling, eating, sexual activity, and working). Compared to other instruments assessing addiction problems, models using the SSBA provided equivalent or better model fit, and overall had higher classification accuracy in the prediction of self-attributed problems.Discussion and conclusionsThe SSBA is a viable screening tool for problematic engagement across ten potentially addictive behaviors. Where longer screening tools are not appropriate, the SSBA may be used to identify individuals who would benefit from further assessment.
Higher levels of (Internet) Gaming Disorder symptoms according to the WHO and APA frameworks associate with lower striatal volume
Authors: Zhou Xinqi , Wu Renjing , Liu Congcong , Kou Juan , Chen Yuanshu , Pontes Halley M. , Yao Dezhong , Kendrick Keith M. , Becker Benjamin , Montag Christian 
Published: October 2020

AbstractBackground and aimsGrowing concerns about the addictive nature of Internet and computer games led to the preliminary recognition of Internet Gaming Disorder (IGD) as an emerging disorder by the American Psychiatric Association (APA) and the official recognition of Gaming Disorder (GD) as a new diagnosis by the World Health Organization (WHO). While the definition of clear diagnostic criteria for (I)GD represents an important step for diagnosis and treatment of the disorder, potential neurobiological correlates of the criteria remain to be explored.MethodsThe present study employed a dimensional Magnetic Resonance Imaging (MRI) approach to determine associations between (I)GD symptom-load according to the APA and WHO diagnostic frameworks and brain structure in a comparably large sample of n = 82 healthy subjects.ResultsHigher symptom-load on both, the APA and WHO diagnostic frameworks convergently associated with lower volumes of the striatum.DiscussionThe results from this exploratory study provide the first initial evidence for a neurobiological foundation of the proposed diagnostic criteria for (I)GD according to both diagnostic classification systems and suggest that the transition from non-disordered to disordered gaming may be accompanied by progressive neuroplastic changes in the striatum, thus resembling progressive changes in other addictive disorders.ConclusionsThe proposed (I)GD criteria in both diagnostic systems were associated with neurostructural alterations in the striatum, suggesting an association with progressive changes in the motivational systems of the brain.
Using deliberate mind-wandering to escape negative mood states: Implications for gambling to escape
Authors: Kruger Tyler B. , Dixon Mike J. , Graydon Candice , Stange Madison , Larche Chanel J. , Smith Stephen D. , Smilek Daniel 
Published: October 2020

AbstractBackground and aims:Slot machines are a pervasive form of gambling in North America. Some gamblers describe entering “the slot machine zone”—a complete immersion into slots play to the exclusion of all else.Methods:We assessed 111 gamblers for mindfulness (using the Mindful Attention Awareness Scale (MAAS)), gambling problems (using the Problem Gambling Severity Index (PGSI)), depressive symptoms (using the Depression, Anxiety, and Stress Scale), and boredom proneness (using the Boredom Proneness Scale). In a counterbalanced order, participants played a slot machine simulator and completed an auditory vigilance task. During each task, participants were interrupted with thought probes to assess whether they were: on-task, spontaneously mind-wandering, or deliberately mind-wandering. After completing each task, we retrospectively assessed flow and affect. Compared to the more exciting slots play, we propose that gamblers may use deliberate mind-wandering as a maladaptive means to regulate affect during a repetitive vigilance task.Results:Our key results were that gamblers reported greater negative affect following the vigilance task (when compared to slots) and greater positive affect following slots play (when compared to the vigilance task). We also found that those who scored higher in problem gambling were more likely to use deliberate mind-wandering as a means to cope with negative affect during the vigilance task. Using hierarchical multiple regression, we found that the number of “deliberately mind-wandering” responses accounted for unique variance when predicting problem gambling severity (over and above depression, mindfulness, and boredom proneness).Conclusions:These assessments highlight a potential coping mechanism used by problem gamblers in order to deal with negative affect.