bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotoxicity including posterior reversible encephalopathy syndrome after initiation of calcineurin inhibitors in transplanted methylmalonic acidemia patients: Two case reports and review of the literature
Authors: Molema Femke , Williams Monique , Langendonk Janneke , Darwish‐Murad Sarwa , van de Wetering Jacqueline , Jacobs Ed , Onkenhout Willem , Brusse Esther , van der Eerden Anke , Wagenmakers Margreet 
Published: January 2020

AbstractIntroductionNew neurological symptoms in methylmalonic acidemia (MMA) patients after liver and/or kidney transplantation (LKT) are often described as metabolic stroke‐like‐events. Since calcineurin inhibitors (CNIs) are a well‐known cause of new neurological symptoms in non‐MMA transplanted patients, we investigated the incidence of CNI‐induced neurotoxicity including posterior reversible encephalopathy syndrome (PRES) in post‐transplanted MMA patients.MethodsWe report the two MMA patients treated with LKT in our center. Additionally, we performed a systematic review of case reports/series of post‐transplanted MMA patients and determined if CNI‐induced neurotoxicity/PRES was a likely cause of new neurological symptoms. Definite CNI‐induced neurotoxicity was defined as new neurological symptoms during CNI treatment with symptom improvement after CNI dose reduction/discontinuation. PRES was defined as CNI‐induced neurotoxicity with signs of vasogenic edema on brain magnetic resonance imaging (MRI)‐scan post‐transplantation.ResultsOur two MMA patients both developed CNI‐induced neurotoxicity, one had PRES. In literature, 230 transplanted MMA patients were identified. Neurological follow‐up was reported in 54 of them, of which 24 were excluded from analysis since no anti‐rejection medication was reported. Thirty patients, all using CNI, were included. Sixteen patients (53%) had no new neurological symptoms post‐transplantation and five patients (17%) had definite CNI neurotoxicity of whom two had PRES. Including our cases this results in a pooled incidence of 22% (7/32) definite CNI neurotoxicity and 9% PRES (3/32) in post‐transplanted MMA patients on CNI.ConclusionIn MMA post‐transplanted patients with new neurological symptoms CNI‐induced neurotoxicity/PRES should be considered. Early recognition of CNI‐induced neurotoxicity is essential to initiate dose reduction/discontinuation of CNI to minimize persistent neurologic damage and improve outcome.Concise one sentence take home messageIn all post‐transplanted MMA patients with new neurological symptoms CNI‐induced neurotoxicity/PRES should be considered, and directly reducing the dose/discontinuation of CNI is essential.
Emerging coronaviruses: Genome structure, replication, and pathogenesis
Authors: Chen Yu , Liu Qianyun , Guo Deyin 
Published: January 2020

AbstractThe recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health. In this minireview, we provide a brief introduction of the general features of CoVs and describe diseases caused by different CoVs in humans and animals. This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats.
Cross‐species transmission of the newly identified coronavirus 2019‐nCoV
Authors: Ji Wei , Wang Wei , Zhao Xiaofang , Zai Junjie , Li Xingguang 
Published: January 2020

AbstractThe current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019‐nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many initial patients were exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals were also sold. To investigate possible virus reservoir, we have carried out comprehensive sequence analysis and comparison in conjunction with relative synonymous codon usage (RSCU) bias among different animal species based on the 2019‐nCoV sequence. Results obtained from our analyses suggest that the 2019‐nCoV may appear to be a recombinant virus between the bat coronavirus and an origin‐unknown coronavirus. The recombination may occurred within the viral spike glycoprotein, which recognizes a cell surface receptor. Additionally, our findings suggest that 2019‐nCoV has most similar genetic information with bat coronovirus and most similar codon usage bias with snake. Taken together, our results suggest that homologous recombination may occur and contribute to the 2019‐nCoV cross‐species transmission.
Remodeling of the interstitial extracellular matrix in white matter multiple sclerosis lesions: Implications for remyelination (failure)
Authors: de Jong Jody M. , Wang Peng , Oomkens Michelle , Baron Wia 
Published: January 2020

AbstractThe extracellular matrix (ECM) provides protection, rigidity, and structure toward cells. It consists, among others, of a wide variety of glycoproteins and proteoglycans, which act together to produce a complex and dynamic environment, most relevant in transmembrane events. In the brain, the ECM occupies a notable proportion of its volume and maintains the homeostasis of central nervous system (CNS). In addition, remodeling of the ECM, that is transient changes in ECM proteins regulated by matrix metalloproteinases (MMPs), is an important process that modulates cell behavior upon injury, thereby facilitating recovery. Failure of ECM remodeling plays an important role in the pathogenesis of multiple sclerosis (MS), a neurodegenerative demyelinating disease of the CNS with an inflammatory response against protective myelin sheaths that surround axons. Remyelination of denuded axons improves the neuropathological conditions of MS, but this regeneration process fails over time, leading to chronic disease progression. In this review, we uncover abnormal ECM remodeling in MS lesions by discussing ECM remodeling in experimental demyelination models, that is when remyelination is successful, and compare alterations in ECM components to the ECM composition and MMP expression in the parenchyma of demyelinated MS lesions, that is when remyelination fails. Inter‐ and intralesional differences in ECM remodeling in the distinct white matter MS lesions are discussed in terms of consequences for oligodendrocyte behavior and remyelination (failure). Hence, the review will aid to understand how abnormal ECM remodeling contributes to remyelination failure in MS lesions and assists in developing therapeutic strategies to promote remyelination.
Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons
Authors: Locke Ryan C. , Lemmon Elisabeth A. , Dudzinski Ellen , Kopa Sarah C. , Wayne Julianna M. , Soulas Jaclyn M. , De Taboada Luis , Killian Megan L. 
Published: January 2020

AbstractTendon rupture can occur at any age and is commonly treated nonoperatively, yet can result in persisting symptoms. Thus, a need exists to improve nonoperative treatments of injured tendons. Photobiomodulation (PBM) therapy has shown promise in the clinic and is hypothesized to stimulate mitochondrial‐related metabolism and improve healing. However, the effect of PBM therapy on mitochondrial function during tendon maturation and healing are unknown, and its effect on tendon structure and function remain unclear. In this study, near‐infrared light (980:810 nm blend, 2.5 J/cm2) was applied at low (30 mW/cm2) or high (300 mW/cm2) irradiance to unilateral Achilles tendons of CD‐1 mice during postnatal growth (maturation) as well as adult mice with bilateral Achilles tenotomy (healing). The chronic effect of PBM therapy on tendon structure and function was determined using histology and mechanics, and the acute effect of PBM therapy on mitochondrial‐related gene expression was assessed. During maturation and healing, collagen alignment, cell number, and nuclear shape were unaffected by chronic PBM therapy. We found a sex‐dependent effect of PBM therapy during healing on mechanical outcomes (eg, increased stiffness and Young's modulus for PBM‐treated females, and increased strain at ultimate stress for PBM‐treated males). Mitochondria‐related gene expression was marginally influenced by PBM therapy for both maturation and healing studies. This study was the first to implement PBM therapy during both growth and healing of the murine tendon. PBM therapy resulted in marginal and sex‐dependent effects on the murine tendon. Clinical significance: PBM may be beneficial for tendon healing because functional remodeling improves without adverse effects.
Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury, and full‐thickness cartilage defect models
Authors: Peal Bridgette T. , Gagliardi Rachel , Su Jin , Fortier Lisa A. , Delco Michelle L. , Nixon Alan J. , Reesink Heidi L. 
Published: January 2020

AbstractThe objectives of this study were to evaluate temporal changes in lubricin, hyaluronan (HA), and HA molecular weight (MW) distributions in three distinct models of equine joint injury affecting the carpal (wrist), tarsal (ankle), and femoropatellar (knee) joints. To establish ranges for lubricin, HA, and HA MW distributions across multiple joints, we first evaluated clinically healthy, high‐motion equine joints. Synovial fluid was collected from high‐motion joints in horses without clinical signs of joint disease (n = 11 horses, 102 joints) and from research horses undergoing carpal osteochondral fragmentation (n = 8), talar cartilage impact injury (n = 7), and femoral trochlear ridge full‐thickness cartilage injury (n = 22) prior to and following arthroscopically induced joint injury. Lubricin and HA concentrations were measured via enzyme‐linked immunosorbent assays, and gel electrophoresis was performed to evaluate HA MW distributions. Synovial fluid parameters were analyzed via linear regression models, revealing that lubricin and HA concentrations were conserved across healthy, high‐motion joints. Lubricin concentrations increased post‐injury in all osteoarthritis models (carpal fragmentationP = .001; talar impactP < .001; femoral trochlear ridge cartilage defectP = .03). Sustained loss of HA was noted post‐arthroscopy following carpal osteochondral fragmentation (P < .0001) and talar impact injury (P < .001). Lubricin may be elevated to compensate for the loss of HA and to protect cartilage post‐injury. Further investigation into the mechanisms regulating lubricin and HA following joint injury and their effects on joint homeostasis is warranted, including whether lubricin has value as a biomarker for post‐traumatic osteoarthritis.
Detection of DDT and carbaryl pesticides in honey by means of immunosensors based on high fundamental frequency quartz crystal microbalance (HFF‐QCM)
Authors: Cervera‐Chiner Lourdes , March Carmen , Arnau Antonio , Jiménez Yolanda , Montoya Ángel 
Published: January 2020

AbstractBACKGROUNDIn recent years there has been a concern about the presence of pesticides in honey because residues of DDT and carbaryl were found in honey samples. Traditional techniques, such as chromatography, reach the required limits of detection (LOD) but are not suitable for in situ implementation in the honey‐packaging industry due to their high cost and the need for highly qualified staff for routine operation. Biosensors offer simplicity, low cost, and easy handling for analytical purposes in food applications.RESULTSPiezoelectric immunosensors based on high fundamental frequency quartz crystal microbalance (HFF‐QCM) have been developed for the detection of carbaryl and DDT in honey. Biorecognition was based on competitive immunoassays in the conjugate‐coated format, using monoclonal antibodies as specific immunoreagents. The assay LODs attained by the HFF‐QCM immunosensors were 0.05 μg L−1 for carbaryl and 0.24 μg L−1 for DDT, reaching a similar level of detectability to that of the usual reference techniques. The practical LODs in honey samples were 8 μg kg−1 for carbaryl and 24 μg kg−1 for DDT. The immunosensors’ analytical performance allow the detection of these pesticides in honey at EU regulatory levels with good accuracy (recovery percentages ranging from 94% to 130% within the working range of each pesticide standard curve) and precision (coefficients of variation in the 9–36% range).CONCLUSIONThe proposed immunosensor is a promising analytical tool that could be implemented for quality control in the honey packaging industry, to simplify and to reduce the cost of the routine pesticide analysis in this appreciated natural food. © 2020 Society of Chemical Industry
Flower‐like layered double hydroxide‐modified stainless‐steel fibers for online in‐tube solid‐phase microextraction of Sudan dyes
Authors: Yuan Zaicheng , Zhou Wei , Chen Zilin 
Published: January 2020

AbstractLayered double hydroxides are a family of inorganic crystals that have gained a lot of attention due to its special structure and properties such as high porosity, large specific area, and excellent anion exchange ability. In this work, flower‐like NiAl‐layered double hydroxides with high specific area were in situ immobilized onto the stainless steel fibers by bioinspired polydopamine modification method and packed into poly (ether ether) ketone tube for online solid‐phase microextraction with high performance liquid chromatography analysis. Thanks to the high specific surface area and excellent extraction ability of the NiAl‐layered double hydroxides, the fibers showed excellent extraction performance to three Sudan dyes with enrichment factors between 260 to 650 folds. After optimization of the reaction and extraction conditions, an online solid‐phase microextraction method was developed for determination of Sudan dyes in water samples and chili samples. The method has limits of detection of 0.01 to 0.02 ng/mL, good linearity and good reproducibility (≤1.45%).
Trimethylchlorosilane, (CH3)3SiCl: OH reaction kinetics and infrared spectrum
Authors: Papanastasiou Dimitrios K. , Bernard François , Burkholder James B. 
Published: January 2020

AbstractRate coefficients for the OH + (CH3)3SiCl (trimethylchlorosilane) gas‐phase reaction were measured over the temperature range 295–375 K using a pulsed laser photolysis laser‐induced fluorescence technique. The room temperature rate coefficient was determined to be k1(295 K) = (2.51 ± 0.13) × 10−13 cm3 molecule–1 s–1. The Arrhenius expression k1(T) = (7.06 ± 2.15) × 10−12 exp[–(992 ± 101)/T] cm3 molecule–1 s–1, where the quoted uncertainties are 2σ fit precision, describes the measured temperature dependence very well. As part of this work, the infrared spectra of CH3)3SiCl was measured.
Multimodal strategy for the management of sphenoid osteoradionecrosis: Preliminary results
Authors: Daoudi Hannah , Labeyrie Marc A. , Guillerm Sophie , Delanian Sylvie , Guichard Jean‐Pierre , Jourdaine Clément , Faivre Sandrine , Gauthier Helene , Ferrand François‐Régis , Verillaud Benjamin , Herman Philippe 
Published: January 2020

AbstractObjectiveOsteoradionecrosis (ORN) of the sphenoid is a rare but potentially lethal complication that can occur after irradiation of nasopharyngeal and clival malignancies. The objective of this study was to describe a multimodal treatment strategy tailored to the clinical signs and to the radiological extent of the disease, and to report on its preliminary results.MethodsRetrospective monocentric study at a tertiary skull base center. Patients treated for a sphenoid ORN from January 2014 to August 2018 were identified and charts were retrospectively reviewed for demographics, histologic tumor type, previous treatments of the tumor, clinical signs at presentation, radiological data, treatment, and outcomes. Sphenoid ORN was treated by a combination of medical therapy, endovascular treatment, and/or surgery. The use of each of these therapeutic modalities was based on the extent of ORN and on the presenting signs.ResultsSeven patients were included: four patients underwent endovascular treatment with occlusion of the internal carotid artery, five patients underwent surgical debridement, and covering of the exposed bone by a local flap, seven patients received antibiotics (in combination with pentoxyphilline, tocopherol, and clodronate in one case). Three patients died after progression of the ORN. The global survival rate was 57% (4/7) with a mean follow‐up of 24 months. In one case, ORN was treated successfully by medical treatment only, with a combination of antibiotics, pentoxyphilline, tocopherol, and clodronate.ConclusionThis retrospective study describes the results of a management strategy adapted to the extent of the disease in sphenoid ORN and based on medical therapy only, or on a combination of medical therapy, interventional radiology, and/or surgery.Level of evidence4
2‐Oxo‐2(tert‐butyldimethylsilyl)Acetic Acid (DKSi‐COOH) as a New Water‐Soluble Visible Light Type I Photoinitiator for Free Radical Polymerization
Authors: Kirschner Julie , Paillard Julien , Graff Bernadette , Becht Jean‐Michel , Klee Joachim E. , Lalevée Jacques 
Published: January 2020

Abstract2‐Oxo‐2‐(tert‐butyldimethylsilyl)acetic acid (DKSi‐COOH), is proposed here as a new high‐performance photoinitiator (PI) for the free radical polymerization of methacrylates under blue light irradiation. In the presence of DKSi‐COOH, very good polymerization performances are reached and outstanding bleaching properties are obtained compared to traditionally used camphorquinone‐based photoinitiating systems. Remarkably, this new developed PI exhibits good water solubility and excellent stability in acidic conditions and represents therefore a promising candidate for water‐based formulations.
When distraction may be a good thing: The role of distraction in low‐fit brand extension evaluation
Authors: Zhang Yuli , Kwak Hyokjin , Puzakova Marina , Taylor Charles R. 
Published: January 2020

AbstractThis study examines the effect of distraction after being exposed to information on low‐fit brand extension evaluation. We show that when consumers are distracted (vs. engaging in deliberate thinking) after encoding extension information they evaluate low‐fit brand extensions more favorably. Findings suggest that distraction can help establish connections of remotely associated information between a parent brand and a low‐fit extension. We also find that the effect of distraction is contingent on the individual characteristic of consumers' agency–communion orientation. The core effect holds strongly for consumers high in communion orientation, but not for those with an agency orientation. Finally, we examine how marketing communication strategies (i.e., manipulating product message construal level) interact with distraction to influence consumer perceptions of low‐fit brand extensions. Theoretical and practical implications of these findings are discussed.
Anti‐consumption beyond boundaries: From niche topic to global phenomena
Authors: Lee Michael S. W. , Ortega Egea José M. , García de Frutos Nieves 
Published: January 2020

AbstractThe first anti‐consumption special issue was published by Psychology & Marketing in 2002. More than a decade later, in 2018, the International Center for Anti‐consumption Research held its seventh Symposium at the University of Almeria, Spain. This gathering was accompanied by an open call‐for‐papers in Psychology & Marketing to create a much‐anticipated follow‐up special issue. Many papers were received for both the symposium and official call. This editorial introduces the final 10 papers that comprise the Psychology & Marketing 2020 special issue on anti‐consumption. While the area of anti‐consumption has mushroomed into a vast array of work since 2002, this editorial provides four major themes that help to frame the contributions of the 10 new papers as well as set the scene for future work in anti‐consumption. The four themes are: Conceptual clarity and refinement; ideological perspectives; environmental and sustainability focus; and novel outlooks on anti‐consumption.
Mechanisms Governing the Transfer of Pure and Plant Matrix Carotenoids Toward Emulsified Triglycerides
Authors: Goupy Pascale , Genot Claude , Hammaz Faiza , Halimi Charlotte , Caris‐Veyrat Catherine , Borel Patrick 
Published: January 2020

ScopeThe study aims to assess the role of factors assumed to be involved in the transfer of carotenoids from plant matrices to dietary emulsions in the upper digestive tract.Methods and ResultsTransfer is first measured as a function of time of pure β‐carotene (βC), lutein (LUT), and lycopene (LYC) to triglyceride (TG) droplets dispersed in water. Then the transfer to TG droplets stabilized with either bovine serum albumin (BSA), phospholipids (PL), or both is measured. Finally, transfer of tomato and spinach puree carotenoids to these emulsions is measured. The maximal transfer efficiency of the pure carotenoids to uncoated emulsions is very efficient, ranging from 59% to 77%. However, it is dramatically impaired, ranging from 0.5% to 31% (p < 0.05), when emulsions are stabilized by the emulsifiers. Conversely, when LUT, and to a less extent βC, but not LYC, is provided by the vegetable purees, its maximal transfer efficiency is significantly higher for the coated emulsions than for the uncoated one.ConclusionsEmulsifiers can dramatically impair the transfer of pure carotenoids to emulsion TG while they can facilitate the transfer of carotenoids from plant matrices. This suggests that specific interactions between plant matrix compounds and emulsifiers can enhance the transfer efficiency of carotenoids.
High‐resolution 2‐D NMR spectroscopy based on the Radon transform and pure shift technique for studying chemical shifts perturbations
Authors: Chen Jinyong , Zeng Qing , Tian Dan , Lin Yanqin , Chen Zhong 
Published: January 2020

AbstractChemical shift plays an important role in molecular analysis. However, chemical shifts are influenced by temperature, solvent concentration, pressure, and so forth. Therefore, measuring chemical shift perturbations caused by these factors is helpful to molecular studies. A new form of 2‐D spectroscopy (projection spectroscopy) has been introduced whose indirect dimension is derived by implementing the Radon transform on a series of conventional 1‐D proton spectra and indicates such perturbations. However, signal overlap may exist in the conventional 1‐D spectra and hence in the resulting projection spectra, hampering clear multiplet analysis and accurate extraction of perturbations. Here, the pure shift decoupling technique is employed to obtain clearer projection spectrum with higher spectral resolution. The combination of pure shift technique and the Radon transform is helpful to accurately extract chemical shift perturbations. It is believed that this application will open up a vast prospect for molecular analysis.