bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory T Cell Stability and Migration Are Dependent on mTOR
Authors: Vallion Romain , Divoux Jordane , Glauzy Salomé , Ronin Emilie , Lombardi Yannis , Lubrano di Ricco Martina , Grégoire Sylvie , Nemazanyy Ivan , Durand Aurélie , Fradin Delphine , Lucas Bruno , Salomon Benoit L. 
Published: August 2020

Abstract
CD4+ Foxp3+ regulatory T cells (Treg) are essential to maintain immune tolerance, as their loss leads to a fatal autoimmune syndrome in mice and humans. Conflicting findings have been reported concerning their metabolism. Some reports found that Treg have low mechanistic target of rapamycin (mTOR) activity and would be less dependent on this kinase compared with conventional T cells, whereas other reports suggest quite the opposite. In this study, we revisited this question by using mice that have a specific deletion of mTOR in Treg. These mice spontaneously develop a severe and systemic inflammation. We show that mTOR expression by Treg is critical for their differentiation into effector Treg and their migration into nonlymphoid tissues. We also reveal that mTOR-deficient Treg have reduced stability. This loss of Foxp3 expression is associated with partial Foxp3 DNA remethylation, which may be due to an increased activity of the glutaminolysis pathway. Thus, our work shows that mTOR is crucial for Treg differentiation, migration, and identity and that drugs targeting this metabolism pathway will impact on their biology.
Berber Factor in North Africa: Common Features and Local Peculiarities
Authors: Zinin Yu. 
Published: August 2020

The article considers a place and influence of Berber-speaking communities in each of five countries of the North Africa: Algeria, Morocco, Libya, Mauritania and Tunis.After gaining the independence, demands are growing in all these states to recognize cultural, regional, and sometimes political peculiarities of Berbers.The situation in every country is different due to local conditions and background of interactions of Amazigs (self-designation of Berber) with the Arab speaking majority, as well as their participation in political processes.The author investigates and discuss the impact of the Arab Spring on the rise of self-consciousness, solidarity and consolidation of Amazig minority. It is Berber, often European educated elite which usually expresses and propagates such conceptions and trends.
Eurasian Economic Union – Realities of the Current Situation
Authors: Chernyavskiy S. 
Published: August 2020

Eurasian integration is Russia’s most important foreign policy project. In the face of economic sanctions, it faces additional difficulties. A very painful problem is overcoming the tendency to reduce mutual trade, since the reserves for the growth of mutual trade associated with the removal of administrative barriers have been exhausted, and the range of goods remains virtually unchanged. The development of trade within the EEU is hampered by a drop in world prices on commodity markets, which has led to a decrease in solvency within the Union. To overcome this negative trend can only be through a significant diversification of commodity exchange. Despite the abolition of customs borders between the members of the union, it was not possible to eliminate all exemptions and restrictions at the previous stages of the development of the EEU.The sanctions regime introduced by the European Union and Russia’s response measures created additional problems in the development of the internal market of the EEU. One of the obstacles to Eurasian integration is the lack of activity of mutual investment activities. The goals set by the Eurasian integration should be clear, concrete, and, most importantly, achievable, and the results - tangible not only for governments and business circles, but also for the population of the countries concerned.
Disagreements between Member States of the GCC as a Factor of the Political Situation in the Middle East Region
Authors: Kuznetsov A. A. 
Published: August 2020

The paper deals with the phenomenon of the Qatari-Saudi rivalry in the Middle East in the context of dissimilarities between political programs and aspirations of the two states in the Middle East.The following research undertakings are realized in the article:• an explanation of the reasons of Qatar and the Saudi Kingdom’s domination in the Arab politics of the last 15 years;• an analysis of the Qatari foreign policy and the regional geopolitical agenda of Qatar;• an inquiry into the reasons and driving forces of the Saudi-Qatari conflict;• a study of the external actors’ influence on the Saudi-Qatari conflict, taking into account the changers in the U.S. foreign policy;• investigation of the different political strategies of the Saudi Arabia and UAE in Yemen which may lead to disintegration of this country.The author emphasizes four main reasons for the Saudi-Qatari rivalry: support by the Qatari leadership of the international movement Muslim Brotherhood; tribal rivalry among the families of al-Saud and al-Thani; struggle for the ideological heritage of Muhammad Abdel Wahhab; different approaches to Iran, and its role in the region.
110 years of the Second Hague Conference: role of the Russian diplomacy and International Law doctrine of F. Martens
Authors: Voronin E. 
Published: August 2020

Facts backed up by documents and contemporary testimonies must serve as a basis for the consequencies of the events of 1917, as a verification of any impartial estimation and indiscriminate view on the most brutal revolt in history, and its consequences.The Russian society needs an impartial, just and deep analysis of these events. Foremost this would require a clear civilised understanding of the real essence of any coup d’etat, whatever name it takes (revolution, classjustified struggle, etc) and whatever banners it bears in history, and whatever propaganda and ideological falcifications determine it.The Constitution of any state ruled by law acknowledges any evolution in the development of the sociaty based on legal principles. Any change of institutes or social system in a state can be realised through the force of laws, which comply with the public expression of will (referendum). In national legislation of the present-day states there are no norms, which establish revolutionary convulsions as legal, which are based on illegitimate take-over with the use of force.
IMPLEMENTATION OF THE FREE EDUCATION POLICY IN PRIMARY SCHOOLS IN KAFUE DISTRICT: IS IT A COMPROMISE ON QUALITY OF EDUCATION IN ZAMBIA?
Authors: Mwanza Christine , Silukuni Darious 
Published: August 2020

<p>In this study, researchers investigated the implementation of Free Primary Education Policy in selected primary schools of Kafue district of Zambia. The study’s objective was to determine the possible conflicts that had arose between learners’ access to education and supply of quality education. As a descriptive survey, the study population consisted of one hundred and twenty (120) teachers, twenty-four (24) head teachers one (2) Ministry of General Education (MoGE) officials. The teachers responded to a questionnaire while the head teachers and MoGE officials were interviewed using structured interview schedules. An observation checklist was used to record the schools’ enrolments, equipment and facilities that were available. Data was analyzed thematically as themes and sub themes emerged from the data. Finding showed that there were high enrolments in Kafue primary schools, an indication that many learners had free access to education but this led to a number of challenges such as: inadequate educational supplies, low staffing levels, inadequate classrooms and desks. Teachers were being overworked and were unable to attend to individual needs of pupils. They also could not manage to give adequate homework and remedial work due to large classes. Consequently, the Zambian government seems to have failed to meet the needs of primary schools in Kafue due to the surge in enrolments. Scholars in this study recommended that the Ministry of General Education should evaluate the practicality and sustainably of the Free Primary Education in all primary schools in Kafue district. Furthermore, additional funds should be allocated for schools to enable them buy teaching and learning materials.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0696/a.php" alt="Hit counter" /></p>
Bridging the Gap: The Value of Science in Coaching
Authors: Langford Andrew 
Published: August 2020

Science is one of the greatest achievements of mankind. It has saved billions of lives, created astonishing technology, solved global problems, and helped raise the standard of living for all. But science is often misinterpreted and misapplied, and sometimes has a negative reputation in the coaching community. Part of the problem is that the definition of science varies for different people. We may use the word science to mean the facts that we know about the world – the force of gravity, the mass of an object, the anatomy of the knee etc. These are clear, objective facts, and cannot be disputed. However, we may also use the term science to mean scientific thinking, clear thinking, or critical thinking. This is where we might not know the exact facts about something, but we can use the principles of evidence, logic, rationality and reason to make a strong inference about it. We can then test, analyse and evaluate, deciding on what has worked and why. This is evidence-based practice. Scientist Carl Sagan put it well when he said, “science is a way of thinking much more than it is a body of knowledge.”
Bridging the Gap: The Importance of Evidence-Based Practice and Collaboration within Sports Performance
Authors: Waller Griffin 
Published: August 2020

The role of a Strength & Conditioning Coach (S&CC) has evolved tremendously over the years. Formerly, these positions were seen as novelties, with responsibilities centered solely around improving strength and conditioning qualities. Currently, job responsibilities can stretch from not only applying strength and conditioning principles, but also being competent in biomechanics, human anatomy, exercise physiology, motor learning, sports nutrition, and sports psychology, to name a few. It’s vital for S&CCs to lean on relevant research, while collaborating with both direct and indirect professionals to guide decision making. Adopting an evidence-based practice (EBP) should be the first step when determining the best intervention in any situation. Applying this to strength and conditioning would be to take a systematic approach to training athletes and clients based on the best evidence from current peer-reviewed research, in conjunction with professional experience and judgment. Ultimately, EBP can provide S&CCs with strength of certainty regarding their decisions. In addition to the research, individual experience and observation, in conjunction with the preferences and constraints of the environment, are just as important. Both scientific research and practical experience are necessary and complementary components of furthering EBP. Developing the best EBP will require a combined approach, in which coaches and researchers work in collaboration to provide the greatest degree of insight into the effects of any intervention. Cultivating sustainable, integrated, and open-minded work relationships can heavily influence how we’re assimilating important information. Sharing information and an adopting an open-minded approach can lead to skills, techniques, and research being shared far more easily. Ultimately, integrating an EBP and fostering quality professional relationships at work sets the foundation to optimize decision-making and minimize interference within the development of our athletes.
PERANCANGAN SISTEM PENGUKUR TINGGI BADAN BERBASIS MIKROKONTROLLER MENGGUNAKAN SENSOR ULTRASONIK
Authors: Hanafie Ahmad , Umar Bowasis , Husnah Nurul , Yunus Sukma 
Published: August 2020

Penelitian ini bertujuan untuk merancang sebuah alat pengukur tinggi badan yang berbasis mikrokontroller menggunakan sensor ultrasonik untuk memudahkan pengguna dalam pengukuran tinggi badan.Sistem ini terdiri dari beberapa komponen elektronik seperti LCD, Mikrokontroller, Sensor Ultrasonik, dan masih banyak lagi yang dibangun menggunakan bahasa pemrograman bahasa C. Adapun metode penelitian yang digunakan dalam eksperimen ini adalah pengujian langsung alat.Hasil dari tugas akhir ini adalah sebuah alat pengukur tinggi badan berbasis mikrokontroller yang menggunakan sensor ultrasonik yang dilengkapi dengan tampilan hasil ukur tinggi badan melalui LCD. Berdasarkan hasil pembuatan, pengoperasian, dan pengujian alat, diketahui bahwa mekanisme kerja alat pengukur tinggi badan berbasis mikrokontroller menggunakan sensor ultrasonik bekerja sesuai dengan harapan dan teori yang mendukung.
PEMBUATAN MODUL BERBASIS KOMPUTER PADA MATA KULIAH PRAKTEK DASAR DAN PENGUKURAN LISTRIKTEKNIK ELEKTRONIKA UNIVERSITAS NEGERI MAKASSAR
Authors: Nuralamsyah Nuralamsyah , Rosmiati Rosmiati 
Published: August 2020

Penelitian ini merupakan penelitian perancangan bertujuan untuk membuat suatu Modul Berbasis Komputer pada Mata Kuliah Praktek Dasar dan Pengukuran Listrik Jurusan Teknik Elektronika Fakultas Teknik Universitas Negeri Makassar, dan untuk mengetahui spesifikasi Modul berbasis komputer pada mata kuliah Praktek dasar dan Pengukuran Listrik Jurusan Teknik Elektronika Fakultas Teknik UNM. Program modul berbasis komputer ini dibuat dengan menggunakan software Macromedia Flash 8 Proffesional dan beberapa Software pendukung yakni Macromedia Fireworks 8 Profesional, Microsoft Office 2007, PDF Creator, Camtasia Studio 5, dan Adobe Reader. Tahapan-tahapan perancangan modul berbasis komputer dimulai dari pengambilan data yakni dengan mengumpulkan data-data yang berupa file-file text, gambar, sound (musik/suara) maupun video, kemudian dilanjutkan dengan tahap perancangan dan pembuatan desain
modul yang menghasilkan sketsa perancangan awal dalam bentuk flowchart, kemudian dilanjutkan dengan tahap pengeditan data dan dilanjutkan dengan tahap pemasukan data, dan diakhiri dengan tahap pengujian. Hasil akhir dari perancangan modul berbasis komputer diperoleh sistem pembelajaran praktikum berupa simulasi praktikum berbasis video yang ditunjang dengan modul jobsheet praktikum Praktek Dasar dan Pengukuran Listrik sebagai tuntunan praktikum. Diharapkan dalam pengembangan kedepannya program Modul Berbasis Komputer pada Mata Kuliah Praktek Dasar dan Pengukuran Listrik jumlah simulasi praktikum dapat ditambahkan, ukuran file yang lebih kecil, kualitas video lebih jelas, animasi yang lebih menarik dan diharapkan program ini dapat digunakan diseluruh system operasi komputer.
PERANCANGAN ALAT UJI SHOCK ABSORBER SEPEDA MOTOR
Authors: Habiba Muhammad Syahrir , Jamaluddin Jamaluddin , Ramdhan Muhammad Alif , Saputra La Ode Budi 
Published: August 2020

Shock absorber sepeda motor yang sangat berperan penting untuk melalui jalan raya yang tidak stabil agar pengguna sepeda motor merasa nyaman. Tujuan penelitian adalah untuk mengetahui kelayakan shock absorber sepeda motor. Jenis penilitian dengan metode kuantitatif. Dengan menggunakan besi ST 37 hollow 40mm x 40mm x 2mm, dongkran botol dan alat ukur pressure guagge. Perhitungan ini menggunakan struktur rangka dengan bantuan aplikasi SAP2000. Hasil penelitian beban maksimal 402 kg/cm2 pada rangka bagian atas dengan hasil perhitungan mendaptkan nilai diagram SFD 201 kg, BMD 38190 kg, defleksi yang diterima 0,337657 mm at 190 mm dan beban maksimal 201 kg/cm2 pada rangka bagian bawah dengan hasil perhitungan mendaptkan nilai diagram SFD 100,5 kg, BMD 1507,5 kg, defleksi yang diterima 0,087599 mm at 150,00 mm menggunakan aplikasi SAP2000. Sehingga di simpulkan perancangan alat uji absorber sepeda motor dapat mengetahui nilai tekanan shock absorber tersebut dan dapat mengetahui kelayakan shock absorber sepeda motor.
PERANCANGAN SISTEM INFORMASI KARTU KUNING (AK.1) UNTUK PENCARI KERJA KANTOR DINAS KETENAGAKERJAAN KOTA MAKASSAR
Authors: Sukirman Sukirman , Rosmiati Rosmiati , Alamsyah Nur , Kamal Kamal 
Published: August 2020

Pelayanan Kartu Kuning pada Dinas Ketenagakerjaan Kota Makassar masih terbilang manual karena para pencari kerja masih harus datang ke loket administrasi untuk membuat kartu kuning. Tujuan penelitian ini untuk merancang sistem informasi kartu kuning AK.1 pada Dinas Ketenagakerjaan Kota Makassar untuk memudahkan para pencari kerja dalam pembuatan kartu kuning. Penelitian ini menggunakan metode Rapid Application Development (RAD) dengan pengembangannya melalui model System Development Life Cycle (SDLC). Hasil penelitian ini adalah pelayanan pembuatan kartu kuning (AK1) akan lebih efektif dan efisien karena pelayanan pembuatan kartu kuning (AK1) dapat dilakukan dimana saja dan kapanpun. Sistem Informasi ini digunakan oleh 3 (tiga) entitas yaitu admin, operator dan pencari kerja. Admin dapat melihat daftar pencari kerja, lowongan pekerjaan, perusahaan yang disertai dengan grafik pengunjung sistem informasi. Untuk operator dan pencari kerja tersedia menu untuk data pencari kerja, data pendidikan, data pengalaman kerja dan data pelatihan. Sistem informasi ini juga disertai dengan pencetakan kartu kuning (AK 1) dan menu perpanjangan masa kartu kuning (AK1). Dengan adanya sistem informasi ini, pencari kerja cukup mengisi form data diri dan data pengalaman kerja dan dapat dilakukan di rumah menggunakan laptop atau smartphone dan jaringan internet. Sistem informasi ini harus memverifikasi akun pencari kerja karena penyimpanan databasenya secara online sehingga membuat pegawai bekerja dengan lebih mudah dan lebih cepat.
PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN PELANGGAN DALAM PEMBELIAN MOBIL TOYOTA AVANZA DI PT KALLA TOYOTA CABANG COKROAMINOTO
Authors: Suradi Suradi , Andrie Andrie , Fadel Ahmad Muhammad 
Published: August 2020

Kualitas Layanan merupakan aktivitas yang dilakukan seseorang atau sekelompok orang dengan landasan faktor material melalui sistem, prosedur, dan metode tertentu dalam rangka memenuhi kebutuhan orang lain sesuai dengan haknya. Tujuan penelitian mengetahui pengaruh kualitas layanan (tangible, reliability, responsiveness, assurance, empahty) dengan kepuasan pelanggan, khususnya pada pembelian. Jenis penelitian ini merupakan penelitian deskriptif. Menggunakan uji validitas dan reabilitas. Berdasarkan hasil penelitian diketahui bahwa Hubungan positif dan signifikan ditunjukkan bahwa meningkatnya kualitas pelayanan yang terdiri atas tangible, reliability, responsiveness, assurance dan emphaty kepuasan pelanggan. Pengumpulan data melalui observasi, wawancara, dan pembagian kuesioner kepada karyawan. Hasil dari penelitian ini menunjukkan bahwa variabel tangible berpengaruh secara positif dan tidak signifikan terhadap kepusasan pelanggan. Kesimpulan kualitas pelayanan yang paling berpengaruh terhadap kepuasan pelanggan adalah emphaty. Dengan demikian, hipotesis yang menyatakan bahwa kualitas pelayanan yang paling berpengaruh dominan adalah reliability tidak terbukti.
A Three Year Study on Drug Abuse Tests at Hospital Tengku Ampuan Rahimah (HTAR), Selangor Malaysia
Authors: Phing Lee Seow 
Published: August 2020

This study focused on drug epidemic in Selangor for 3 consecutive years (2016-2018). Hospital Tengku Ampuan Rahimah (HTAR) analysed an estimate of 12988 samples for drug abuse( opiates and cannabinoids) from 2016 until 2018 . Being the centre for receiving samples collected by Police and National Anti-Drug agencies in Southwest Selangor, these areas were combed for analytical study of habitual abusers, their age-related patterns and ethnic origins for better understanding and planning for advocates of control .
The interaction between urbanization and aerosols during a typical winter haze event in Beijing
Authors: Yu Miao , Tang Guiqian , Yang Yang , Li Qingchun , Wang Yonghong , Miao Shiguang , Zhang Yizhou , Wang Yuesi 
Published: August 2020

Abstract. Aerosols cause cooling at the surface by reducing shortwave radiation, while
urbanization causes warming by altering the surface albedo and releasing
anthropogenic heat. The combined effect of the two phenomena needs to be
studied in depth. The effects of urbanization and aerosols were investigated
during a typical winter haze event. The event, which occurred in Beijing
from 15 to 22 December 2016, was studied via the Rapid-Refresh Multiscale
Analysis and Prediction System – Short Term (RMAPS-ST) model. The mechanisms
of the impacts of aerosols and urbanization were analyzed and quantified.
Aerosols reduced urban-related warming during the daytime by 20 % (from 30 %
to 50 %) as concentrations of fine particulate matter (PM2.5) increased from 200 to
400 µg m−3. Conversely, aerosols also enhanced urban-related
warming at dawn, and the increment was approximately 28 %, which
contributed to haze formation. Urbanization reduced the aerosol-related
cooling effect by approximately 54 % during the haze event, and the
strength of the impact changed little with increasing aerosol content. The
impact of aerosols on urban-related warming was more significant than the
impact of urbanization on aerosol-related cooling. Aerosols decreased the
urban impact on the mixing-layer height by 148 % and on the sensible heat
flux by 156 %. Furthermore, aerosols decreased the latent heat flux;
however, this reduction decreased by 48.8 % due to urbanization. The
impact of urbanization on the transport of pollutants was more important
than that of aerosols. The interaction between urbanization and aerosols may
enhance the accumulation of pollution and weigh against diffusion.
Project Management Practices and Performance of Women Economic Empowerment in Kiambu and Nairobi Counties, Kenya
Authors: Kaluai Faith Kathure , Muathe Stephen 
Published: August 2020

The major concern regarding humanitarian program in the developing world is that they do not address the larger socio-economic challenges hence, not being sustainable. Even though, the application of project management practices in Africa shows positive project outcomes, the project management practices usage has been largely low. Hence, the study sought to determined the influence of project management practices on performance of Kenya’s Women and Girls Economic Empowerment program performance in Kiambu and Nairobi counties, Kenya. Specifically, the study sought to determine the influence of stakeholder’s involvement, project planning, risk management and monitoring and evaluation on program performance. The study was anchored on the stakeholder theory, prospect theory, contingency theory and realistic evaluation theory. This study adopted a census research design. The population targeted were staff of the CARE’s Kenya’s Women and Girls Economic Empowerment program comprising of project managers, project coordinators, quality control officers, government officials and beneficiary representatives. Semi-structured questionnaire was adopted for data collection. Descriptive statistics and multiple regression were utilized to analyze the quantitative data. The study revealed that risk management contributes the most to Performance of Kenya's Women and Girls Economic Empowerment Program followed by stakeholder involvement, Project Planning and monitoring and evaluation respectively. The study recommends that there is need to come up with more rigorous strategies for making sure that appropriate processes of monitoring and evaluation are adhered to. Further, the program needs to emphasize on risk management linked to empowerment of economy and make staff education on mitigation strategies its priority.