bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant Physiology Increases the Magnitude and Spread of the Transient Climate Response to CO2 in CMIP6 Earth System Models
Authors: Zarakas Claire M. , Swann Abigail L. S. , Laguë Marysa M. , Armour Kyle C. , Randerson James T. 
Published: August 2020

AbstractIncreasing concentrations of CO2 in the atmosphere influence climate both through CO2’s role as a greenhouse gas and through its impact on plants. Plants respond to atmospheric CO2 concentrations in several ways that can alter surface energy and water fluxes and thus surface climate, including changes in stomatal conductance, water use, and canopy leaf area. These plant physiological responses are already embedded in most Earth system models, and a robust literature demonstrates that they can affect global-scale temperature. However, the physiological contribution to transient warming has yet to be assessed systematically in Earth system models. Here this gap is addressed using carbon cycle simulations from phases 5 and 6 of the Coupled Model Intercomparison Project (CMIP) to isolate the radiative and physiological contributions to the transient climate response (TCR), which is defined as the change in globally averaged near-surface air temperature during the 20-yr window centered on the time of CO2 doubling relative to preindustrial CO2 concentrations. In CMIP6 models, the physiological effect contributes 0.12°C (σ: 0.09°C; range: 0.02°–0.29°C) of warming to the TCR, corresponding to 6.1% of the full TCR (σ: 3.8%; range: 1.4%–13.9%). Moreover, variation in the physiological contribution to the TCR across models contributes disproportionately more to the intermodel spread of TCR estimates than it does to the mean. The largest contribution of plant physiology to CO2-forced warming—and the intermodel spread in warming—occurs over land, especially in forested regions.
Possible Influence of Tropical Indian Ocean Sea Surface Temperature on the Proportion of Rapidly Intensifying Western North Pacific Tropical Cyclones during the Extended Boreal Summer
Authors: Gao Jun , Zhao Haikun , Klotzbach Philip J. , Wang Chao , Raga Graciela B. , Chen Shaohua 
Published: August 2020

AbstractThis study examines the possible impact of tropical Indian Ocean (TIO) sea surface temperature anomalies (SSTAs) on the proportion of rapidly intensifying tropical cyclones (PRITC) over the western North Pacific (WNP) during the extended boreal summer (July–November). There is a robust interannual association (r= 0.46) between TIO SSTAs and WNP PRITC during 1979–2018. Composite analyses between years with warm and cold TIO SSTAs confirm a significant impact of TIO SSTA on WNP PRITC, with PRITC over the WNP basin being 50% during years with warm TIO SSTAs and 37% during years with cold TIO SSTAs. Tropical cyclone heat potential appears to be one of the most important factors in modulating the interannual change of PRITC over the WNP with a secondary role from midlevel moisture changes. Interannual changes in these large-scale factors respond to SSTA differences characterized by a tropics-wide warming, implying a possible global warming amplification on WNP PRITC. The possible footprint of global warming amplification of the TIO is deduced from 1) a significant correlation between TIO SSTAs and global mean SST (GMSST) and a significant linear increasing trend of GMSST and TIO SSTAs, and 2) an accompanying small difference of PRITC (~8%) between years with detrended warm and cold TIO SSTAs compared to the difference of PRITC (~13%) between years with nondetrended warm and cold TIO SSTAs. Global warming may contribute to increased TCHP, which is favorable for rapid intensification, but increased vertical wind shear is unfavorable for TC genesis, thus amplifying WNP PRITC.
Future Changes and Controlling Factors of the Eight Regional Monsoons Projected by CMIP6 Models
Authors: Jin Chunhan , Wang Bin , Liu Jian 
Published: August 2020

AbstractAn accurate prediction of land monsoon precipitation (LMP) is critical for the sustainable future of the planet as it provides water resources for more than two-thirds of the global population. Here, we show that the ensemble mean of 24 CMIP6 (phase 6 of the Coupled Model Intercomparison Project) models projects that, under the Shared Socioeconomic Pathway 2–4.5 (SSP2–4.5) scenario, summer LMP will very likely increase in South Asia (~4.1% °C−1), likely increase in East Asia (~4.6% °C−1) and northern Africa (~2.9% °C−1), and likely decrease in North America (~−2.3% °C−1). The annual mean LMP in three Southern Hemisphere monsoon regions will likely remain unchanged due to significantly decreased winter precipitation. Regional mean LMP changes are dominated by the change in upward moisture transport with moderate contribution from evaporation and can be approximated by the changes of the product of the midtropospheric ascent and 850-hPa specific humidity. Greenhouse gas (GHG)-induced thermodynamic effects increase moisture content and stabilize the atmosphere, tending to offset each other. The spatially uniform increase of humidity cannot explain markedly different regional LMP changes. Intermodel spread analysis demonstrates that the GHG-induced circulation changes (dynamic effects) are primarily responsible for the regional differences. The GHGs induce a warm land–cool ocean pattern that strengthens the Asian monsoon, and a warm North Atlantic and Sahara that enhances the northern African monsoon, as well as an equatorial central Pacific warming that weakens the North American monsoon. CMIP6 models generally capture realistic monsoon rainfall climatology, but commonly overproduce summer rainfall variability. The models’ biases in projected regional SST and land–sea thermal contrast likely contribute to the models’ uncertainties in the projected monsoon rainfall changes.
Recent Intensified Runoff Variability in the Hailar River Basin during the Past Two Centuries
Authors: Li Junxia , Bai Xueping , Jin Yuting , Song Fangbo , Chen Zhenju , Cai Lixin , Zou Fenghua , Jiang Mengzhu , Yun Ruixin , Lv Zhaoyang 
Published: August 2020

AbstractUsing tree-ring data of Pinus sylvestris var. mongolica from the Hulun Buir region in northeast China, 12 annual runoff series of the Hailar River spanning the past 202–216 years were established for the first time; these included 11 branches and one for the entire basin. These reconstructions, which could explain 29.4%–52.7% of the total variance for the measured runoffs during 1956–2006, performed well in statistical verification tests. In the whole basin’s reconstruction of 212 years, 34 extreme drought years (16.0%) and 41 extreme pluvial years (19.3%) were identified; 4 of the 10 most extreme years occurred after 1980. The consistent cycle and correlation revealed that the Hailar runoff had a teleconnection with the El Niño–Southern Oscillation (ENSO). The sharply increasing variance at the end of the reconstruction, accompanied by the increasing intensity of short cycles (4–8 years), indicated that runoff variability in the Hailar River basin has enhanced in the late twentieth century. This is verified by the drastic fluctuations in water level and area of rivers and lakes, and the frequent shift of natural land cover types in the Hulun Buir area in recent decades. The intensified runoff variability can be connected with the concurrently enhanced ENSO activity. Our study is the first to identify the intensification of recent runoff variability in the semiarid to arid region in northeast China from a long-term perspective. With projected enhancement of ENSO activity, the Hailar River basin will face the increased risk of extreme hydrological events.
Observations of Flow Separation and Mixing around the Northern Palau Island/Ridge
Authors: Wijesekera Hemantha W. , Wesson Joel C. , Wang David W. , Teague William J. , Hallock Z. R. 
Published: August 2020

AbstractTurbulent mixing adjacent to the Velasco Reef and Kyushu–Palau Ridge, off northern Palau in the western equatorial Pacific Ocean, is examined using shipboard and moored observations. The study focuses on a 9-day-long, ship-based microstructure and velocity survey, conducted in November–December 2016. Several sections (9–15 km in length) of microstructure, hydrographic, and velocity fields were acquired over and around the reef, where water depths ranged from 50 to 3000 m. Microstructure profiles were collected while steaming slowly either toward or away from the reef, and underway current surveys were conducted along quasi-rectangular boxes with side lengths of 5–10 km. Near the reef, both tidal and subtidal motions were important, while subtidal motions were stronger away from the reef. Vertical shears of currents and mixing were stronger on the northern and eastern flanks of the reef than on the western flanks. High turbulent kinetic energy dissipation rates, 10−6–10−4W kg−1, and large values of eddy diffusivities, 10−4–10−2m2s−1, with strong turbulent heat fluxes, 100–500 W m−2, were found. Currents flowing along the eastern side separated at the northern tip of the reef and generated submesoscale cyclonic vorticity of about 2–4 times the planetary vorticity. The analysis suggests that a torque, imparted by the turbulent bottom stress, generated the cyclonic vorticity at the northern boundary. The northern reef is associated with high vertical transports resulting from both submesoscale flow convergences and energetic mixing. Even though the area around Palau represents a small footprint of the ocean, vertical velocities and mixing rates are several orders magnitude larger than in the open ocean.
The Atlantic Meridional Overturning Circulation and the Cabbeling Effect
Authors: Schloesser Fabian 
Published: August 2020

AbstractNorth Atlantic meridional density gradients have been identified as a main driver of the Atlantic meridional overturning circulation (AMOC). Due to the cabbeling effect, these density gradients are increasingly dominated by temperature gradients in a warming ocean, and a direct link exists between North Atlantic mean temperature and AMOC strength. This paper quantifies the impact of this mechanism in the Stommel and Gnanadesikan models. Owing to different feedback mechanisms being included, a 1°C warming of North Atlantic mean ocean temperature strengthens the AMOC by 3% in the Gnanadesikan model and 8% in the Stommel model. In the Gnanadesikan model that increase is equivalent to a 4% strengthening of Southern Hemisphere winds and can compensate for a 14% increase in the hydrological cycle. Furthermore, mean temperature strongly controls a freshwater forcing threshold for the strong AMOC state, suggesting that the cabbeling effect needs to be considered to explain past and future AMOC variability.
Age Effect on Incidence, Physical, and Psychiatric Comorbidity for Sudden Cardiac Death in Schizophrenia: Effet de l’âge sur l’incidence, la comorbidité physique et psychiatrique de la mort cardiaque subite dans la schizophrénie
Authors: Chen Pao-Huan , Tsai Shang-Ying , Pan Chun-Hung , Chang Hu-Ming , Chen Yi-Lung , Su Sheng-Siang , Chen Chiao-Chicy , Kuo Chian-Jue 
Published: August 2020

Objective: The pathogenesis of sudden cardiac death may differ between younger and older adults in schizophrenia, but evidence remains scant. This study investigated the age effect on the incidence and risk of the physical and psychiatric comorbidity for sudden cardiac death. Methods: Using 2000 to 2016 data from the Taiwan National Health Insurance Research Database and Department of Health Death Certification System, we identified a national cohort of 170,322 patients with schizophrenia, 1,836 of whom had a sudden cardiac death. Standardized mortality ratios (SMRs) were estimated. Hazard ratios and population attributable fractions of distinctive comorbidities for sudden cardiac death were assessed. Results: The SMRs of sudden cardiac death were all >1.00 across each age group for both sexes, with the highest SMR in male patients aged <35 years (30.88, 95% CI: 26.18–36.18). The fractions of sudden cardiac death attributable to hypertension and congestive heart failure noticeably increased with age. By contrast, the fraction attributable to drug-induced mental disorder decreased with age. Additionally, chronic hepatic disease and sleep disorder increased the risk of sudden cardiac death in patients aged <35 years. Dementia and organic mental disorder elevated the risk in patients aged between 35–54 years. Ischemic heart disease raised the risk in patients aged ≥55 years. Conclusions: The risk is increased across the lifespan in schizophrenia, particularly for younger male patients. Furthermore, physical and psychiatric comorbidities have age-dependent risks. The findings suggest that prevention strategies targeted toward sudden cardiac death in patients with schizophrenia must consider the age effect.
Eye-selfie to resolve the enigmatic diagnosis of transient “eye spot”
Authors: Iacono Pierluigi , Saviano Sandro , Parravano Mariacristina , Varano Monica , Battaglia Parodi Maurizio 
Published: August 2020

Purpose: To describe two cases of Cobb’s tufts in apparently healthy subjects. Methods: Observational case series. Results: Two patients reporting sudden vision loss, with subsequent complete recovery, underwent a complete ophthalmological examination, including iris fluorescein angiography. Both patients took an “eye-selfie” using their smartphone to provide evidence of the iris bleeding. Iris fluorescein angiography confirmed the presence of iris neovascular tufts at the pupillary margin. Conclusion: Diagnosis of Cobb’s tufts can frequently be challenging. The two patients’ astute action in taking photographs of the eye enabled the condition to be promptly identified.
Protein Kinase D 1 Predicts Poor Treatment Response and Unfavorable Survival of Bortezomib-Based Treatment, and Its Knockdown Enhances Drug Sensitivity to Bortezomib in Multiple Myeloma
Authors: Li Xuesong , Yang Ying , Yi Xue 
Published: August 2020

Objective: The present study aimed to explore the correlation of protein kinase D 1 with prognosis in bortezomib-treated multiple myeloma patients and further investigate the effect of protein kinase D 1 knockdown on drug sensitivity to bortezomib in multiple myeloma cells. Methods: Totally, 104 de novo symptomatic multiple myeloma patients treated with bortezomib-based regimens and 30 healthy controls were recruited. Bone marrow mononuclear cells–derived plasma cells were collected from multiple myeloma patients before initial treatment and from healthy controls on the bone marrow donation, respectively, then protein kinase D 1 protein/messenger RNA expressions were detected by Western blot and reverse transcription quantitative polymerase chain reaction, respectively. The effect of protein kinase D 1 knockdown on drug sensitivity to bortezomib was detected by transfecting protein kinase D 1 knockdown plasmid and control plasmid into RPMI8226 and U266 cells. Results: Protein kinase D 1 protein/messenger RNA expressions were both upregulated in multiple myeloma patients compared with healthy controls and presented good value in differentiating multiple myeloma patients from healthy controls. Furthermore, protein kinase D 1 protein/messenger RNA expressions were both associated with high International Staging System stage and t (4; 14). Furthermore, both complete response rate and overall response rate were reduced in protein kinase D 1 high patients compared with protein kinase D 1 low patients; similarly, progression-free survival and overall survival were both decreased in protein kinase D 1 high patients compared with protein kinase D 1 low patients. In addition, in RPMI8226 and U266 multiple myeloma cells, protein kinase D 1 knockdown increased drug sensitivity to bortezomib. Conclusion: Protein kinase D 1 has the potential to predict poor treatment response and unfavorable survival of bortezomib-based treatment in multiple myeloma patients, and its knockdown enhanced drug sensitivity to bortezomib in multiple myeloma cells.
Can Diffuse Idiopathic Skeletal Hyperostosis Be Diagnosed by Plain Lumbar Spine X-Ray Findings Alone?
Authors: Misaki Hiroshi , Morino Tadao , Hino Masayuki , Murakami Yusuke , Imai Hiroshi , Miura Hiromasa 
Published: August 2020

Study Design: Retrospective case-control study Objectives: To determine whether diffuse idiopathic skeletal hyperostosis (DISH) can be diagnosed based on anterior longitudinal ligamental ossification in the lumbar spine using plain lumbar spine X-ray images. Methods: This study included 100 patients (59 men and 41 women; mean age, 64.8 ± 13.8 years; range, 27-89 years) who underwent computed tomography (CT) of the chest to the pelvis in our hospital and plain lumbar spine radiography within 6 months before and after CT scanning. DISH was diagnosed based on the thoracolumbar spine CT findings using Resnick’s diagnostic criteria. The patients were grouped according to DISH diagnosis into the DISH (+) and DISH (−) groups. On the frontal and lateral lumbar spine X-ray images, each spinal level from Th11/12 to L5/S was scored based on the Mata scoring system. The distribution of the Mata scores was compared between the 2 groups. Results: Forty (40%) patients were diagnosed with DISH based on the CT findings. A cutoff value ≥8 provided a sensitivity of 75% and specificity of 100% for diagnosing DISH, thus, indicating the validity of the cutoff value. In the DISH (−) group, no patient had ≥3 consecutive spinal levels with a Mata score ≥2, suggesting that DISH can be diagnosed on the basis of at least 3 consecutive spinal levels with a Mata score ≥2. Conclusion: On lumbar spine X-ray images of the T11/12 to L5/S levels, a Mata score ≥2 for at least 3 consecutive levels or a total score ≥8 strongly indicates the presence of DISH.
Diabetes Is Predictive of Postoperative Outcomes and Readmission Following Posterior Lumbar Fusion
Authors: Arrighi-Allisan Annie E. , Neifert Sean N. , Gal Jonathan S. , Zeldin Lawrence , Zimering Jeffrey H. , Gilligan Jeffrey T. , Deutsch Brian C. , Snyder Daniel J. , Nistal Dominic A. , Caridi John M. 
Published: August 2020

Study Design: Retrospective cohort study. Objective: The present study analyzes complication rates and episode-based costs for patients with and without diabetes mellitus (DM) following posterior lumbar fusion (PLF). Methods: PLF cases at a single institution from 2008 to 2016 were queried (n = 3226), and demographic and perioperative data were analyzed. Patients with and without the diagnosis of DM were compared using chi-square, Student’s t test, and multivariable regression modeling. Results: Patients with diabetes were older (63.10 vs 56.48 years, P < .001) and possessed a greater number of preoperative comorbidities (47.84% of patients had Elixhauser Comorbidity Index >0 vs 42.24%, P < .001) than did patients without diabetes. When controlling for preexisting differences, diabetes remained a significant risk factor for prolonged length of stay (OR = 1.59, 95% CI 1.26-2.01, P < .001), intensive care unit stay (OR = 1.52, 95% CI 1.07-2.17, P = .021), nonhome discharge (OR = 1.86, 95% CI 1.46-2.37, P < .001), 30-day readmission (OR = 2.15, 95% CI 1.28-3.60, P = .004), 90-day readmission (OR = 1.65, 95% CI 1.05-2.59, P = .031), 30-day emergency room visit (OR = 2.15, 95% CI 1.27-3.63, P = .004), and 90-day emergency room visit (OR = 2.27, 95% CI 1.41-3.65, P < .001). Cost modeling controlling for overall comorbidity burden demonstrated that diabetes was associated with a $1709 increase in PLF costs (CI $344-$3074, P = .014). Conclusions: The present findings indicate a correlation between diabetes and a multitude of postoperative adverse outcomes and increased costs, thus illustrating the substantial medical and financial burdens of diabetes for PLF patients. Future studies should explore preventive measures that may mitigate these downstream effects.
Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international working group
Authors: Fakhouri Fadi , Scully Marie , Provôt François , Blasco Miquel , Coppo Paul , Noris Marina , Paizis Kathy , Kavanagh David , Pène Frédéric , Quezada Sol , Hertig Alexandre , Kissling Sébastien , O’Brien Patrick , Delmas Yahsou , Alberio Lorenzo , Winer Norbert , Veyradier Agnès , Cataland Spero , Frémeaux-Bacchi Véronique , Loirat Chantal , Remuzzi Giuseppe , Tsatsaris Vassilis 
Published: August 2020

Abstract
Pregnancy and postpartum are high-risk periods for different forms of thrombotic microangiopathy (TMA). However, the management of pregnancy-associated TMA remains ill defined. This report, by an international multidisciplinary working group of obstetricians, nephrologists, hematologists, intensivists, neonatologists, and complement biologists, summarizes the current knowledge of these potentially severe disorders and proposes a practical clinical approach to diagnose and manage an episode of pregnancy-associated TMA. This approach takes into account the timing of TMA in pregnancy or postpartum, coexisting symptoms, first-line laboratory workup, and probability-based assessment of possible causes of pregnancy-associated TMA. Its aims are: to rule thrombotic thrombocytopenic purpura (TTP) in or out, with urgency, using ADAMTS13 activity testing; to consider alternative disorders with features of TMA (preeclampsia/eclampsia; hemolysis elevated liver enzymes low platelets syndrome; antiphospholipid syndrome); or, ultimately, to diagnose complement-mediated atypical hemolytic uremic syndrome (aHUS; a diagnosis of exclusion). Although they are rare, diagnosing TTP and aHUS associated with pregnancy, and postpartum, is paramount as both require urgent specific treatment.
Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy
Authors: Lin Binbin , Wang Yuting , Zhang Piao , Yuan Yanyan , Zhang Ying , Chen Gang 
Published: August 2020

AbstractNeuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unfortunately, the precise pathogenesis of NP has not been elucidated. Currently, the microbiota-gut-brain axis has drawn increasing attention, and the emerging role of gut microbiota is investigated in numerous diseases including NP. Gut microbiota is considered as a pivotal regulator in immune, neural, endocrine, and metabolic signaling pathways, which participates in forming a complex network to affect the development of NP directly or indirectly. In this review, we conclude the current understanding of preclinical and clinical findings regarding the role of gut microbiota in NP and provide a novel therapeutic method for pain relief by medication and dietary interventions.