bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppression of MET Signaling Mediated by Pitavastatin and Capmatinib Inhibits Oral and Esophageal Cancer Cell Growth
Authors: Xu Bo , Muramatsu Tomoki , Inazawa Johji 
Published: December 2020

Abstract

Despite increasing knowledge on oral and esophageal squamous cell carcinoma (OSCC and ESCC), specific medicines against both have not yet been developed. Here, we aimed to find novel anticancer drugs through functional cell-based screening of an FDA-approved drug library against OSCC and ESCC. Pitavastatin, an HMGCR inhibitor, emerged as an anticancer drug that inhibits tumor growth by downregulating AKT and ERK signals in OSCC and ESCC cells. One of the mechanisms by which pitavastatin inhibits cell growth might be the suppression of MET signaling through immature MET due to dysfunction of the Golgi apparatus. Moreover, the sensitivity of tumor growth to pitavastatin might be correlated with GGPS1 expression levels. In vivo therapeutic models revealed that the combination of pitavastatin with capmatinib, a MET-specific inhibitor, dramatically reduced tumor growth. Our findings suggest that GGPS1 expression could be a biomarker in cancer therapy with pitavastatin, and the combination of pitavastatin with capmatinib might be a promising therapeutic strategy in OSCC and ESCC.

Implications:
This study provides new insight into the mechanism of pitavastatin as an anticancer drug and suggests that the combination of pitavastatin with capmatinib is a useful therapeutic strategy in OSCC and ESCC.
Foreign to Palestinian Society? ʿUrfī Marriage, Moral Dangers, and the Colonial Present
Authors: Johnson Penny , Moors Annelies 
Published: December 2020

Abstract
In 2005, religious authorities in Palestine warned publicly of a new phenomenon, one that was ‘foreign to Palestinian society’: ʿurfī marriages. They used this term to refer to ‘secret marriages,’ which they considered as linked to social breakdown, the result of the Israeli occupation. In the tales (similar to rumors) of young men and women throughout the West Bank and Gaza in the early 2010s, these marriages were often related to the colonial geographies of anxiety, of social and political fragmentation, and of the spatial segregation that Israel has imposed on Palestinians. Related concerns were expressed by the men of religion as they attempted to maintain their authority in highly uncertain times and in contested spaces. Still, in the very small number of concrete cases shariʿa judges continued to use the flexibility of Islamic jurisprudence to legally recognize ʿurfī marriages to work towards the most equitable solution in problematic situations.
Decomposing the Drivers of Polar Amplification with a Single-Column Model
Authors: Henry Matthew , Merlis Timothy M. , Lutsko Nicholas J. , Rose Brian E. J. 
Published: December 2020

AbstractThe precise mechanisms driving Arctic amplification are still under debate. Previous attribution methods compute the vertically uniform temperature change required to balance the top-of-atmosphere energy imbalance caused by each forcing and feedback, with any departures from vertically uniform warming collected into the lapse-rate feedback. We propose an alternative attribution method using a single-column model that accounts for the forcing dependence of high-latitude lapse-rate changes. We examine this method in an idealized general circulation model (GCM), finding that, even though the column-integrated carbon dioxide (CO2) forcing and water vapor feedback are stronger in the tropics, they contribute to polar-amplified surface warming as they produce bottom-heavy warming in high latitudes. A separation of atmospheric temperature changes into local and remote contributors shows that, in the absence of polar surface forcing (e.g., sea ice retreat), changes in energy transport are primarily responsible for the polar-amplified pattern of warming. The addition of surface forcing substantially increases polar surface warming and reduces the contribution of atmospheric dry static energy transport to the warming. This physically based attribution method can be applied to comprehensive GCMs to provide a clearer view of the mechanisms behind Arctic amplification.
Evaluation of KDP Estimation Algorithm Performance in Rain Using a Known-Truth Framework
Authors: Reimel Karly J. , Kumjian Matthew 
Published: December 2020

AbstractAccurate estimation of specific differential phase (KDP) is necessary for rain rate estimation, attenuation correction, and hydrometeor classification algorithms. There are numerous published methods to process polarimetric radar observations of propagation differential phase shift (ΦDP) and estimate KDP, but the corresponding KDP estimate uncertainty is unquantified. This study provides guidance on how commonly used KDP estimation algorithms perform in various environments. We create numerous synthetic (“true”) KDP profiles, integrate over them to obtain “smoothed” ΦDP, and then add noise typical of S-band operational weather radar measurements. Each algorithm is applied to our noisy ΦDP profiles and compared to the true KDP profile such that the errors and uncertainty are quantified. The synthetic KDP profiles are Gaussian in shape, which allows systematic variations in their magnitude and width to determine how each algorithm performs in smooth, slowly changing KDP profiles, as well as steep profiles. Results demonstrate that algorithm performance is dependent on the ΦDP field received. These results are further supported by an error analysis of each algorithm for two more complicated synthetic KDP profiles. Some KDP algorithms allow users to change various tuning parameters; a subset of these tuning parameters is tested to provide guidance on how changing these parameters impacts algorithm performance. We then provide evidence that our known-truth framework provides insight into algorithm performance in observed data through two case studies.
Observing System Simulation Experiments Investigating Atmospheric Motion Vectors and Radiances from a Constellation of 4–5-μm Infrared Sounders
Authors: McCarty Will , Carvalho David , Moradi Isaac , Privé Nikki C. 
Published: December 2020

AbstractA set of observing system simulation experiments (OSSEs) was performed to investigate the utility of a constellation of passive infrared spectrometers, strategically designed with the aim of deriving the three-dimensional retrievals of the horizontal wind via atmospheric motion vectors (AMVs) from instruments with the spectral resolution of an infrared sounder. The instrument and constellation designs were performed in the context of the Midwave Infrared Sounding of Temperature and humidity in a Constellation for Winds (MISTiC Winds). The Global Modeling and Assimilation Office OSSE system, which includes a full suite of operational meteorological observations, served as the control. To illustrate the potential impact of this observing strategy, two experiments were performed by adding the new simulated observations to the control. First, perfect (error free) simulated AMVs and radiances were assimilated. Second, the data were made imperfect by adding realistic modeled errors to the AMVs and radiances that were assimilated. The experimentation showed beneficial impacts on both the mass and wind fields, as based on analysis verification, forecast verification, and the assessment of the observations using the forecast sensitivity to observation impact (FSOI) metric. In all variables and metrics, the impacts of the imperfect observations were smaller than those of the perfect observations, although much of the positive benefit was retained. The FSOI metric illustrated two key points. First, the largest impacts were seen in the middle troposphere AMVs, which is a targeted capability of the constellation strategy. Second, the addition of modeled errors showed that the assimilation system was unable to fully exploit the 4.3-μm carbon dioxide absorption radiances.
An Umbrella Review of Text Message Programs for Adults With Type 2 Diabetes
Authors: Whittemore Robin , Siverly Lauren , Wischik Dora Lendvai , Whitehouse Christina R. 
Published: December 2020

Purpose The purpose of this umbrella review was to synthesize the evidence from published systematic reviews on the effectiveness of text message programs for adults with type 2 diabetes (T2DM) on glycemic management (A1C), self-management, and other clinical outcomes. The effect of directionality of the program was also explored. Methods A systematic search was conducted using multiple databases. Inclusion criteria were systematic review of text message programs for adults with T2DM, evaluated A1C, and English language. Quality assessment was completed using AMSTAR-2 guidelines. Data were extracted by multiple coders, and results were synthesized. Results The final sample included 9 systematic reviews published between 2011 and 2019, with 72 unique international studies. Text message programs focused on diabetes self-management and reducing health risks through educational and motivational content with some providing personalized feedback. A meta-analysis of program effect on A1C was conducted in 5 reviews with a pooled difference in A1C from −0.38% to −0.8%. Adults with T2DM of shorter duration and lower A1C had better treatment effects. Evidence on unidirectional versus bidirectional programs is conflicting; however, both improve outcomes. Evidence of text message programs targeting medication engagement was inconclusive. Some programs improved blood pressure, lipids, self-management, self-efficacy, and health behaviors. High satisfaction and an average of 9.6% to 18.7% attrition was reported. Conclusions Text messaging programs can improve T2DM outcomes, are a highly accessible mode of communication, are relatively inexpensive, and are an underutilized adjunct to clinical care.
Exploring young children’s activity and participation change following 6 months’ power mobility experience
Authors: Livingstone Roslyn W , Field Debra A 
Published: December 2020

Introduction This pre-post study explored the effect of children’s 6 months’ experience in one of four early power mobility devices. Method Satisfaction with parent-selected goal achievement was measured using the wheelchair outcome measure for young people and compared with the assessment of learning powered mobility use, as well as device expectation fulfilment ratings. Results Forty-six children with mobility limitations, aged 13–68 months (mean 40.40; SD 15.60) participated. The most common condition was cerebral palsy ( n = 33; 71.74%). The Wilcoxon signed rank test measured the positive change in goal achievement ( z = 4.90; P<0.001; r = 0.51). Fair to good statistically significant Spearman’s correlations were observed between power mobility skill and goal achievement, as well as parent and therapist device expectation scores ( rs = 0.48, 0.46 and 0.66, respectively; P<0.001). Parent and therapist ratings did not differ significantly. No statistically significant associations were found between goal achievement and child (age, diagnosis, abilities) or environmental factors (device, access method, loan length). Conclusion Children at all phases of power mobility skill, using various devices and access methods, can demonstrate activity and participation change following power mobility experience. This study adds validity evidence supporting the use of the wheelchair outcome measure for young people with young children by parent-proxy rating.
The Implications of the Triumph of Neoclassical Economics over Marxist Economics in China
Authors: Cohn Steve 
Published: December 2020

This paper explores the implications of one of the great intellectual revolutions of the late twentieth and early twenty-first centuries, the replacement of Marxist economics by neoclassical economics in China. The analysis summarizes what is distinctive about Marxist and neoclassical ways of thinking. The paper then demonstrates how these differences led to different framings and different conclusions about a number of key topics related to the development of capitalism in China. Among the topics explored are the merits of state-owned enterprises, the nature of inequality in China, and the relationship between capitalism and the environment. The paper concludes with a discussion of the different policy agendas that emerge from the different framings offered by neoclassical and Marxist economics. JEL Classification: B41, B51, P2, O53
Impact of a Systematic Pharmacist-Initiated Antibiotic Time-Out Intervention for Hospitalized Adults
Authors: Paulson Calley M. , Handley Jillian F. , Dilworth Thomas J. , Persells Dan , Prusi Rachael Y. , Brummitt Charles F. , Torres Katherine M. , Skrupky Lee P. 
Published: December 2020

Introduction: Antibiotic time-outs (ATO) are a recommended antimicrobial stewardship action, but data assessing their impact are lacking. This study investigated the impact of a systematic, pharmacist initiated ATO intervention. Methods: This pre-post study included inpatients on hospitalist and intensivist services receiving empiric antibiotics for ≥48 hours. The ATO was initiated by pharmacists after 48 hours of empiric therapy and the outcome was documented including antibiotic indication, plan, and duration. An electronic medical record (EMR) alert facilitated ATO completion and pharmacists and prescribers received education prior to implementation. The primary outcome was EMR documentation of an antibiotic plan by 72 hours. Secondary outcomes included antibiotic utilization and antibiotic therapy modifications by 2 hours. Results: 399 patients were included, 199 pre- and 200 post-intervention. The most common indications were pneumonia (32%), intra-abdominal infection (20%) and urinary tract infection (19%), with no between-group differences. EMR documentation of an antibiotic plan significantly improved in the post-intervention group (19% vs. 79%, p<0.0001) as did modifications to antibiotic therapy. The median duration of in-hospital antibiotic therapy was similar between groups (4.0 vs. 4.0 days, p = 0.2499). Approximately 45% of patients in each group received discharge antibiotics and median duration of discharge antibiotic therapy prescribed was reduced (7 vs. 5 days in the pre- and post-intervention groups, respectively; p = 0.0140). Discussion: Implementation of pharmacist initiated ATO was associated with improvements in supporting EMR documentation and antibiotic therapy modifications. These findings highlight an important role in which pharmacists can serve as part of a collaborative antibiotic stewardship team.
Sociodemographic and clinical variables associated with discharge under compulsory treatment orders
Authors: Dey Sangeeta , Mellsop Graham , Obertova Zuzana , Jenkins Matthew 
Published: December 2020

Objective: To document the sociodemographic and clinical variables associated with discharge under compulsory treatment orders in patients with schizophrenia or related disorders. Method: Information on various sociodemographic and clinical variables were extracted from the clinical files of 349 patients discharged from an adult (age 18–65) inpatient psychiatric unit with diagnoses of schizophrenia or related disorders. Univariate and multiple logistic regression analyses with legal compulsion (compulsory versus voluntary) as outcomes were applied. Results: Two hundred of the 349 discharged patients were placed under compulsory treatment orders. In the univariate logistic regression analysis, unemployment, diagnosis of schizophrenia, forensic history, dosage of antipsychotics, prescription and frequency of injectable antipsychotics, polypharmacy and a hospital stay of more than 28 days were associated with compulsory status. Being married or in partnership and living with partner was associated with voluntary status. Multiple regression models respectively confirmed most of these relationships observed in the univariate analyses. Conclusion: Clarification of the apparent drivers for compulsory treatment may help thoughtful reductions in the use of compulsion.
Bilateral diabetic papillopathy developed after starting insulin treatment. Potential toxic effect of insulin? A case report
Authors: Mafrici Marco , Toscani Laura , Lorenzi Umberto 
Published: December 2020

Background: Diabetic papillopathy is a complication of diabetes. It presents with edema, uni or bilateral and vascular alteration of the anterior optic nerve. Often this complication is observed in patients with severe diabetic retinopathy, but is rarely observed in isolated form. Some authors believe that diabetic papillitis is a particular form of non-arteritic anterior ischemic optic neuropathy (NAION). But there is important evidence that confers an inflammatory component to diabetic papillopathy. We report in this work a rare case of isolated acute bilateral diabetic papillopathy developed in a diabetic patient after adding the insulin to the oral hypoglycemic therapy. Case presentation: Male patient, 49-years-old, diabetic type 2, with altered glycemia at follow up, with clinical history of HbA1c 8% to 12% in the last 2 years, on oral hypoglycemic therapy for 10 years. He never had a history of diabetic retinopathy. At the last check-up, this patient presented bilateral papillopathy, without reduction of visual acuity bilaterally. The patient reports he added 10 days before the insulin therapy to the oral hypoglycemic therapy, under medical supervision. Hematochemical and serological tests were requested, which excluded the presence of inflammatory and infectious diseases. The brain magnetic resonance imaging (MRI) with gadolinium excluded the hypothesis of optic neuritis or intracranial hypertension. Cardio-circulatory tests were normal. Fluorescein angiographic examinations and optical coherence tomography (oct) confirmed the bilateral edema and the thickening of optic nerve without other retinal damage. Therefore he was diagnosed with bilateral diabetic papillopathy. Then, diabetologists added pump insulin treatment to the oral hypoglycemic therapy. After 2 months, his blood sugar levels and HbA1C improved and papillopathy regressed. Conclusion: We have reported a rare case of bilateral acute diabetic papillopathy associated with the addition of insulin to the oral hypoglycemic therapy. A randomized control study with diabetic patients, would be useful to verify the possible injuries of the optic nerves during the delicate transition to insulin therapy.
Geochemical discrimination of the altered volcanic tuff from sediments in the Lunpola Basin, central Tibetan Plateau
Authors: Mao Ziqiang , Fang Xiaomin , Yang Yibo , Ye Chengcheng , Zhang Tao , Zhang Weilin , Zan Jinbo 
Published: December 2020

AbstractVolcanic tuffs are important in determining the stratigraphic age of sedimentary sequences, which is closely related to the tectonic, sedimentological, geomorphological, palaeoclimatic, and palaeo-ecological evolution of the sequences. However, it may be difficult practically to identify tuffs in stratigraphic sections, especially when they are altered after deposition. In this study, a series of petrographic, mineralogical, and geochemical analyses was deployed in the tuff layers cropping out in the Lunpola Basin of the central Tibetan Plateau, which is a crucial site for studying the dynamics and processes of the Cenozoic uplift of the Tibetan Plateau and its environmental impacts. In these pyroclastic layers, authigenic analcime is the main volcanic glass alteration product. The analcime-bearing samples are Na-enriched, in contrast to the K-abundant magmatic rocks in the central Tibetan Plateau. The distribution patterns of the rare earth elements (REEs) of the bulk analcime-bearing samples are similar to those of the magmatic rocks but different from those of the analcime-poor sediments and analogues of well-mixed upper continental material (e.g. the upper continental crust and post-Archaean Australian average shales). The distinct distributions of Na and REEs among analcime-bearing samples, analcime-poor sediments, and volcanic rocks reveal that analcime formed both from alteration of volcanic material and from mixing processes with non-volcanic sediments. It is proposed, therefore, that the discrimination plot of Na2O/Al2O3-(La/Yb)Nmay be used to distinguish the analcime-related pyroclastic rocks from the basin sedimentary sequence, and thus it may provide a means of discriminating between various volcanic material and of supporting age dating by tephrochronology in the central Tibetan Plateau.
Medications for attention-deficit/hyperactivity disorder in individuals with or without coexisting autism spectrum disorder: analysis of data from the Swedish prescribed drug register
Authors: Johansson Viktoria , Sandin Sven , Chang Zheng , Taylor Mark J. , Lichtenstein Paul , D’Onofrio Brian M. , Larsson Henrik , Hellner Clara , Halldner Linda 
Published: December 2020

Abstract
Background
Clinical studies found that medication for attention-deficit/hyperactivity disorder (ADHD) is effective in coexisting autism spectrum disorder (ASD), but current research is based on small clinical studies mainly performed on children or adolescents. We here use register data to examine if individuals with ADHD and coexisting ASD present differences in the prescribing patterns of ADHD medication when compared to individuals with pure ADHD.

Methods
Data with information on filled prescriptions and diagnoses was retrieved from the Swedish Prescribed Drug Register and the National Patient Register. We identified 34,374 individuals with pure ADHD and 5012 individuals with ADHD and coexisting ASD, aged between 3 and 80 years. The first treatment episode with ADHD medications (≥ 2 filled prescriptions within 90 days) and daily doses of methylphenidate during a 3-year period was measured. Odds ratios (ORs) were calculated for the likelihood of being prescribed ADHD medication in individuals with and without ASD and Wilcoxon rank-sum test was used to compare group differences in dose per day.

Results
Individuals with ADHD and coexisting ASD were less likely to start continuous treatment with ADHD medication (ADHD 80.5%; ADHD with ASD 76.2%; OR, 0.80; 95% confidence interval, 0.75-0.86), were less likely to be prescribed methylphenidate, and were more commonly prescribed second line treatments such as dexamphetamine, amphetamine, or modafinil. No group difference was observed for atomoxetine. In adults with ADHD and coexisting ASD, methylphenidate was prescribed in lower daily doses over three years as compared to individuals with pure ADHD.

Conclusions
The findings indicate that there are differences in the medical treatment of individuals with or without ASD. If these differences are due to different medication responses in ASD or due to other factors such as clinicians’ perceptions of medication effects in patients with ASD, needs to be further studied.