bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmural difference in myocardial damage assessed by layer-specific strain analysis in patients with ST elevation myocardial infarction
Authors: Kim Sua , Cho Dong-Hyuk , Kim Mi-Na , Hong Soon-Jun , Yu Cheol Woong , Lim Do-Sun , Shim Wan Joo , Park Seong-Mi 
Published: July 2020

AbstractWe performed layer-specific strain analysis with speckle-tracking echocardiography to investigate the transmural difference of myocardial damage as the predicting factor for the viability of damaged myocardium in patients with ST segment elevation myocardial infarction (STEMI). We analysed patients with acute STEMI who had undergone primary percutaneous coronary intervention and echocardiography within 24 h from the intervention and 2 months after the event. Segmental strains of the left ventricular (LV) endocardium, myocardium, epicardium, and strain gradient (SG) between the endocardium and epicardium were evaluated. In 34 patients, 112 akinetic/dyskinetic and 94 hypokinetic segments were observed among 612 segments of the LV at baseline, and 65 akinetic/dyskinetic segments had viability. In our study, layer-specific strains were gradually deteriorated by their wall motion. SG was augmented in the hypokinetic segments where inhomogeneous wall motion impairment was progressed. SG in the akinetic/dyskinetic segments was different between the viable and non-viable myocardium and was maintained in viable segments. We therefore believe that significantly reduced SG is indicative of irreversible transmural damage in the acute stage of STEMI and can be suitably used as a parameter for predicting myocardial viability.
Theoretical investigations on mechanisms and kinetics of the CH3CFClO2· with ClO· reaction in the atmosphere
Authors: Zhang Yunju , He Bing , Sun Yuxi 
Published: July 2020

AbstractThe singlet and triplet potential energy surfaces of the ClO• radical reaction with the CH3CFClO2• radical have been investigated at the CCSD(T)/cc-pVTZ level based on the optimized geometries at the B3LYP/6–311++G(d,p) level. On the singlet potential energy surfaces (PES), the possible reaction involves association-dissociation, direct H-abstraction and Nucleophilic Substitution 2 (SN2) mechanisms. On the triplet PES, SN2 displacement and direct H-abstraction reaction pathways have been investigated, which are less competitive compared with the reaction pathways on the singlet PES. The rate constants have been calculated at 10–10 to 1010 atm and 200–3,000 K by Rice–Ramsperger–Kassel–Marcus (RRKM) theory for the important product pathways. At 200–800 K, IM1 produced (CH3CFClOOOCl) by collisonal deactivation is dominant; at high temperatures, the production P1 (CH3CFO + ClOOCl) becomes dominate. The calculated rate constants for CH3CFClO2• + ClO• are good agreement with the available experimental value. The atmospheric lifetime of CH3CFClO2• in ClO• is around 3.27 h. TD-DFT computations imply that IM1 (CH3CFClOOOCl), IM2 (CH3CFClOOClO) and IM3 (CH3CFClOClO2) will photolyze under the sunlight.
Impact of histological diagnosis on the treatment of atypical brainstem lesions
Authors: Dellaretti Marcos , Câmara Breno Bezerra Arruda , Ferreira Pedro Henrique Piauilino Benvindo , da Silva Júnior José Batista , Arantes Rosa Maria Esteves 
Published: July 2020

AbstractFor atypical brainstem lesions, histological diagnosis can have an impact on treatment, especially in cases where diffuse glioma is not found. Since radiotherapy is the only therapeutic modality that has shown clinical and radiographic improvement in patients with diffuse glioma, the misdiagnosis of diffuse glioma can have drastic consequences, particularly in patients with nontumorous lesions. Thus, the purpose of this study was to evaluate the impact of histological diagnosis on the treatment of atypical brainstem lesions. This was a retrospective study of 31 patients who underwent biopsy of atypical brainstem lesions. The procedures were performed between January 2008 and December 2018 at the Life Center Hospital and Santa Casa de Belo Horizonte, MG, Brazil. A diagnosis was obtained in 26 (83.9%) cases. Three patients presented complications: one presented bleeding with no clinical repercussions and two showed worsening of neurological deficit, only one of which was definitive. No mortality occurred due to the procedure. The histological diagnosis was diffuse glioma in seven cases (22.6%) and not diffuse glioma in 19 cases (61.3%). Thus, the histological diagnosis had an impact on the treatment of 19 patients (treatment impact rate: 61.3%). The histological diagnosis of intrinsic brainstem lesions is a safe, efficient procedure with a high diagnosis rate, and as such, it should be considered in the management of atypical lesions.
Synthesis, microstructure, multifunctional properties of mayenite Ca12Al14O33 (C12A7) cement and graphene oxide (GO) composites
Authors: Sriwong Chaval , Phrompet Chaiwat , Tuichai Wattana , Karaphun Attaphol , Kurosaki Ken , Ruttanapun Chesta 
Published: July 2020

AbstractThe Pristine Mayenite Ca12Al14O33 (C12A7) Cement was simply synthesized by using solid-state reaction. The C12A7 and Graphene Oxide (GO) composites (C12A7_GO-x) with various contents of the GO suspension loading (x = 0 wt%, 1 wt%, 2 wt%, 3 wt%, and 4 wt%) were directly prepared by mixing the C12A7 and GO. X-ray diffraction results of pristine C12A7 and all C12A7_GO composites indicated a pure phase corresponding to the standard of C12A7 cement. Raman spectroscopy confirmed the existence of GO in all C12A7_GO samples. Scanning Electron Microscopy (SEM) showed the micrometer grain sizes and the occurrence of grain boundary interfaces for GO incorporation in all C12A7_GO samples. UV–Vis spectroscopy revealed the absorption value of all C12A7_GO samples and red shift near longer wavelengths when increasing the GO concentrations. The dielectric constant of C12A7_GO composites can be explained by the high density of free electron charges for the interfacial polarization on the GO surface. The maximum specific capacitance of C12A7_GO-4 electrode of 21.514 at a current density of 0.2 A g−1 can be attributed to the increase in the electrochemically active surface area for the formation of the electrical double layer capacitors behavior and the effects of high surface area GO connections. Also, the mechanical properties exhibited an increase in Vickers indenter hardness (HV) values with increasing GO contents. The highest HV value was 117.8 HV/2 kg at the C12A7_GO-4 sample. These results showed that the composite materials of the pristine C12A7 cement with GO were highly efficient. All in all, the GO material contained a high potential for enhancing low-cost cement materials in multifunctional properties such as optical, dielectric, electrochemical, and mechanical properties.
Blood flow disturbances in the central retinal artery in patients with bilateral optic disc drusen
Authors: Obuchowska Iwona , Ustymowicz Andrzej 
Published: July 2020

AbstractTo evaluate retrobulbar hemodynamics in patients with optic disc drusen (ODD) by color Doppler imaging. A prospective study included 52 patients with bilateral ODD and 50 age-matched controls. Blood flow in the central retinal artery (CRA) in both eyes was evaluated. Peak-systolic velocity (PSV), end-diastolic velocity (EDV), and the resistivity index (RI) were measured. Mean values of the blood flow Doppler parameters were compared between the patients with ODD and the controls. Both PSV and EDV in the CRA were significantly lower in patients with ODD than in the controls (p < 0.001). The RI in the CRA of ODD patients was significantly higher than in the controls (p < 0.001). Women with ODD presented with significantly lower values of PSV and EDV than men (p = 0.05 and p = 0.03, respectively). Arterial hypertension, cigarette smoking and location of ODD in the left or right eye did not exert a significant effect on the blood flow in the CRA. Blood flow in the CRA is considerably disturbed in patients with ODD. This disturbance might result from mechanical stenosis of the vascular wall caused by the drusen. Color Doppler ultrasound is a useful method in the assessment of retrobulbar hemodynamics in ODD.
Abstract Semantic Associative Network Training: A Replication and Update of an Abstract Word Retrieval Therapy Program
Authors: Sandberg Chaleece W. , Gray Teresa 
Published: July 2020

Purpose
We report on a study that replicates previous treatment studies using Abstract Semantic Associative Network Training (AbSANT), which was developed to help persons with aphasia improve their ability to retrieve abstract words, as well as thematically related concrete words. We hypothesized that previous results would be replicated; that is, when abstract words are trained using this protocol, improvement would be observed for both abstract and concrete words in the same context-category, but when concrete words are trained, no improvement for abstract words would be observed. We then frame the results of this study with the results of previous studies that used AbSANT to provide better evidence for the utility of this therapeutic technique. We also discuss proposed mechanisms of AbSANT.

Method
Four persons with aphasia completed one phase of concrete word training and one phase of abstract word training using the AbSANT protocol. Effect sizes were calculated for each word type for each phase. Effect sizes for this study are compared with the effect sizes from previous studies.

Results
As predicted, training abstract words resulted in both direct training and generalization effects, whereas training concrete words resulted in only direct training effects. The reported results are consistent across studies. Furthermore, when the data are compared across studies, there is a distinct pattern of the added benefit of training abstract words using AbSANT.

Conclusion
Treatment for word retrieval in aphasia is most often aimed at concrete words, despite the usefulness and pervasiveness of abstract words in everyday conversation. We show the utility of AbSANT as a means of improving not only abstract word retrieval but also concrete word retrieval and hope this evidence will help foster its application in clinical practice.
Sound Production Treatment for Acquired Apraxia of Speech: An Examination of Dosage in Relation to Probe Performance
Authors: Wambaugh Julie L. , Kallhoff Lydia , Nessler Christina 
Published: July 2020

Purpose
This study was designed to examine the association of dosage and effects of Sound Production Treatment (SPT) for acquired apraxia of speech.

Method
Treatment logs and probe data from 20 speakers with apraxia of speech and aphasia were submitted to a retrospective analysis. The number of treatment sessions and teaching episodes was examined relative to (a) change in articulation accuracy above baseline performance, (b) mastery of production, and (c) maintenance. The impact of practice schedule (SPT-Blocked vs. SPT-Random) was also examined.

Results
The average number of treatment sessions conducted prior to change was 5.4 for SPT-Blocked and 3.9 for SPT-Random. The mean number of teaching episodes preceding change was 334 for SPT-Blocked and 179 for SPT-Random. Mastery occurred within an average of 13.7 sessions (1,252 teaching episodes) and 12.4 sessions (1,082 teaching episodes) for SPT-Blocked and SPT-Random, respectively. Comparisons of dosage metric values across practice schedules did not reveal substantial differences. Significant negative correlations were found between follow-up probe performance and the dosage metrics.

Conclusions
Only a few treatment sessions were needed to achieve initial positive changes in articulation, with mastery occurring within 12–14 sessions for the majority of participants. Earlier occurrence of change or mastery was associated with better follow-up performance.

Supplemental Material

https://doi.org/10.23641/asha.12592190
What Acoustic Studies Tell Us About Vowels in Developing and Disordered Speech
Authors: Kent Ray D. , Rountrey Carrie 
Published: July 2020

PurposeLiterature was reviewed on the development of vowels in children's speech and on vowel disorders in children and adults, with an emphasis on studies using acoustic methods.MethodSearches were conducted with PubMed/MEDLINE, Google Scholar, CINAHL, HighWire Press, and legacy sources in retrieved articles. The primary search items included, but were not limited to, vowels, vowel development, vowel disorders, vowel formants, vowel therapy, vowel inherent spectral change, speech rhythm, and prosody.Results/DiscussionThe main conclusions reached in this review are that vowels are (a) important to speech intelligibility; (b) intrinsically dynamic; (c) refined in both perceptual and productive aspects beyond the age typically given for their phonetic mastery; (d) produced to compensate for articulatory and auditory perturbations; (e) influenced by language and dialect even in early childhood; (f) affected by a variety of speech, language, and hearing disorders in children and adults; (g) inadequately assessed by standardized articulation tests; and (h) characterized by at least three factors—articulatory configuration, extrinsic and intrinsic regulation of duration, and role in speech rhythm and prosody. Also discussed are stages in typical vowel ontogeny, acoustic characterization of rhotic vowels, a sensory-motor perspective on vowel production, and implications for clinical assessment of vowels.
Use of dry carbonic acid gas baths to correct human biological age
Authors: Meshchaninov Viktor , Shcherbakov Denis , Zvezdina Ekaterina , Gavrilov Ilia 
Published: July 2020

Relevance. The physiotherapy method of dry carbonic acid gas baths (DCAGB) mediated through the effects of carbon dioxide (CO2) is a minimally invasive treatment and prevention method of many human diseases. However, the CO2 effect on the rate of human aging has not been sufficiently studied. Therefore, it is relevant to study the effect of dry carbonic acid gas baths (DCAGB) physiotherapy method on peripheral blood indicators and biological age. Purpose. To assess the effect of carbon dioxide in dry carbonic acid gas baths condition on peripheral blood indicators and biological age in patients of different age groups. Patients and methods. An interventional single center controlled clinical trial was conducted on 140 male patients. Within 1 day before the DCAGB sessions course start (10 sessions 40 minutes each) and 1 day after course completion, patients’ peripheral blood samples were studied, as well as biological and cardiopulmonal age on the patented method was determined.
Results. DCAGB course reduced biological age in young and middle-aged patients by 5.5 years (p<0.001), elderly and old patients – by 4.7 years (p<0.001), elderly and old patients had a decrease in cardiopulmonal bio age by 8.6 years (p<0.01).
Conclusion. The course of DCAGB sessions slowed the aging rate of the human body from young to old age, which was probably associated with antihypoxic, antitoxic, antioxidant effects of carbon dioxide, as well as possibly with erythropoiesis activation.
Three-dimensional cartilage-derived construct derived from multipotent mesenchymal stromal cells
Authors: Makeyev Oleg , Korotkov Arteom , Kostyukova Svetlana , Sichkar Daria , Yakovleva Elizaveta 
Published: July 2020

Damage to the cartilage surface of the joints is a common pathology. Conventional drug therapies are effective only at the initial stage of the disease and only slow down the further development of the disease. In subsequent stages, it is necessary to apply surgical methods from replacing a defect to complete prosthetics of a damaged joint.
In order to replace defects in cartilage tissue, a three-dimensional bioequivalent was created based on autologous multipotent mesenchymal stromal cells.
Use of autogenous platelet rich plasma and 3D collagen matrix Fibromatrix for soft tissue regeneration in the treatment of Miller Class I gingival recessions
Authors: Farkhshatova Rushana , Gerasimova Larisa , Kabirova Milyausha 
Published: July 2020

Background: Evaluation of the effectiveness of the integrated use of autogenous platelet plasma and 3D collagen matrix Fibromatrix for the regeneration of soft tissues of the oral cavity in the surgical treatment of Miller Class I gingival recession. Materials and Method: 25 patients were examined and treated. All patients underwent surgical treatment of gingival recession using two-layer techniques of eliminating gingival recession with «3D collagen matrix FibroMATRIX» for the regeneration of soft tissues of the oral cavity and autologous platelet plasma. In all cases, the rehydration of the collagen matrix was carried out in autogenous platelet plasma for 2 minutes. The result was evaluated after 7th day, 14th day, 1 and 3 months. Statistical processing of the studies was carried out in GraphPadPrism v.6.0, using the t-test, Mann-Whitney. Differences were considered significant at p <0.05. Results: Assessment of gingival recession closure and its significant (p <0.05) increase, corresponding to 85% efficiency after treatment in both groups of patients, no significant differences were found in both groups. The best clinical results were achieved in eliminating gingival recessions in the anterior maxilla, showing its 100% efficiency.
Conclusions: The combined use of autogenous platelet plasma and 3D collagen matrix Fibromatrix for the regeneration of soft tissues of the oral cavity is an effective method for treating Miller Class I gingival recession.
Ergeben sich durch die Einführung der 8. Auflage der TNM-Klassifikation Änderungen für eine leitliniengerechte, chirurgische Therapiestrategie des Lungenkarzinoms?
Authors: Robold Tobias , Neumeier Jakob , Ried Michael , Neu Reiner , Sziklavari Zsolt , Grosser Christian , Klinkhammer-Schalke Monika , Hofmann Hans-Stefan 
Published: July 2020

Zusammenfassung
Einleitung Durch die 8. Auflage der TNM-Klassifikation und die aktualisierte S3-Leitlinie ergaben sich in den letzten beiden Jahren Neuerungen in der Stadieneinteilung und Behandlung des Lungenkarzinoms. Ziel dieser Arbeit ist es, die Stadiendifferenzierungen und -wechsel von der 7. hin zur 8. Auflage zu identifizieren und mögliche therapeutische, insbesondere chirurgische Konsequenzen darzustellen.
Methoden Prospektive Datenerhebung aller Lungenkrebsprimärfälle vom 01.01.2016 bis 31.12.2016 an 2 thoraxchirurgischen Zentren und Nachuntersuchung im März 2019. Vergleich der 7. Auflage der Tumorklassifikation für das Lungenkarzinom mit der 8. Auflage in Hinblick auf Veränderungen des Stadiums, Auswirkungen auf die leitliniengerechte, insbesondere chirurgische Therapie des Lungenkarzinoms und das Gesamtüberleben.
Ergebnisse Es konnten 432 Primärfälle einer Lungenkrebserkrankung ermittelt werden. Davon konnten entsprechend der 8. Auflage 82 Patienten (7. Auflage: n = 85) dem Stadium I, 43 (n = 49) Patienten dem Stadium II, 100 (n = 91) Patienten dem Stadium III und 207 (n = 207) Patienten dem Stadium IV zugeordnet werden. Es wurden 81 (18,7%) Veränderungen des Tumorstadiums mit einer deutlichen Tendenz zur Höherstufung (77 Aufwertungen vs. 4 Abwertungen) detektiert. Bei 63 Patienten (14,6%) zeigte sich ein Stadienwechsel innerhalb eines Stadiums (z. B. IIA → IIB), für 18 Patienten (4,1%) ergab die Auswertung einen übergreifenden Stadienwechsel (z. B. IIB → IIIA) mit einer formalen Änderung in der Therapieempfehlung ohne primär operative Therapieindikation bei 12 Patienten (2,8%). Die neu eingeführten Subgruppen (IA1–3, IIIC und IVA/B) ergaben für 290 Patienten (67,1%) eine spezifischere Stadiendifferenzierung. Für die neuen Stadien IVA/B konnte ein signifikanter Unterschied
im 2-Jahres-Überleben dargestellt werden (IVA = 25,2%; IVB = 13,0%; p < 0,05).
Schlussfolgerung Die Weiterentwicklung der TNM-Klassifikation für das Bronchialkarzinom zur aktuellen 8. Auflage zeichnet sich durch eine differenziertere Einteilung aus. Im untersuchten Kollektiv zeigte sich eine deutliche Tendenz zur Höherstufung des Tumorstadiums. Unter Berücksichtigung der aktuellen Empfehlungen aus der S3-Leitlinie reduziert sich daher die Anzahl der Patienten mit formal primärer OP-Empfehlung im Stadium I – IIIA. Vor allem die Veränderungen des T-Status bei gleichbleibendem N-Status und die Aufwertung einzelner Tumorformeln in ein höheres Tumorstadium verursachen diese Dynamik. Das signifikant bessere 2-Jahres-Überleben im Stadium IVA bei singulärer Fernmetastasierung (M1b) und M1a-Metastasierung im Vergleich zum Stadium IVB unterstützt die differenzierte Betrachtung der unterschiedlichen Metastasierungsgrade.
Central Diabetes Insipidus Caused by Arginine Vasopressin Gene Mutation: Report of a Novel Mutation and Review of Literature
Authors: Feldkamp Lara L.I. , Kaminsky Elke , Kienitz Tina , Quinkler Marcus 
Published: July 2020

AbstractFamilial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant
hereditary disorder characterized by severe polydipsia and polyuria that
usually presents in early childhood. In this study, we describe a new
arginine vasopressin (AVP) gene mutation in an ethnic German family with
FNDI and provide an overview of disease-associated AVP-gene mutations that
are already described in literature. Three members of a German family with
neurohypophyseal diabetes insipidus were studied. Isolated DNA from
peripheral blood samples was used for mutation analysis by sequencing the
whole coding region of AVP-NPII gene. Furthermore, we searched the
electronic databases MEDLINE (Pubmed) as well as HGMD, LOVD-ClinVar, db-SNP
and genomAD in order to compare our cases to that of other patients with
FNDI. Genetic analysis of the patients revealed a novel heterozygote
missense mutation in exon 2 of the AVP gene (c.274T>G), which has
not yet been described in literature. We identified reports of more than 90
disease-associated mutations in the AVP gene in literature. The novel
mutation of the AVP gene seems to cause FNDI in the presented German family.
Similar to our newly detected mutation, most mutations causing FNDI are
found in exon 2 of the AVP gene coding for neurophysin II. Clinically, it is
important to think of FNDI in young children presenting with polydipsia and
polyuria.