bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiometabolic risk factors correlated with the incidence of dysglycaemia in a Brazilian normoglycaemic sample: the Baependi Heart Study cohort
Authors: De Oliveira Camila Maciel , Tureck Luciane Viater , Alvares Danilo , Liu Chunyu , Horimoto Andrea Roseli Vançan Russo , de Oliveira Alvim Rafael , Krieger José Eduardo , Pereira Alexandre C. 
Published: January 2020

Abstract
Background
Dysglycaemia is defined by elevated glucose levels in the blood, commonly characterized by impaired fasting glucose, impaired glucose tolerance, elevated glycated haemoglobin, or diabetes mellitus (DM) diagnosis. The abnormal levels of glucose may occur many years before DM, a condition known as prediabetes, which is correlated with comorbidities such as cardiovascular diseases. Therefore, the aim of this study was to investigate the incidence of prediabetic dysglycaemia and its relationship with cardiometabolic risk factors at a 5-year follow-up, based on an initially normoglycaemic sample in the Baependi Heart Study cohort.

Methods
The data used comes from the Baependi Heart Study cohort, which consists of two periods: cycle 1 (2005–2006) and cycle 2 (2010–2013). For this study, we excluded those who had fasting blood glucose ≥ 100 mg/dL or were taking anti-diabetic medications at baseline, and those that had diabetes diagnosed in cycle 2. Mixed-effects logistic regression models were used to assess the association between cardiometabolic risk factors and the incidence of dysglycaemia, including a familiar random effect such as a cluster.

Results
The incidence of prediabetic dysglycaemia was 12.8%, and it did not differ between men and women (14.4% and 11.6%, respectively). Two models were analysed to investigate the relationship between cardiometabolic risk factors and the occurrence of prediabetic dysglycaemia. The model that better explained the occurrence of dysglycaemia over the 5 years, after correction, included the waist circumference (WC) (measures and Δ), systolic blood pressure (SBP), HDL-c levels, and age. Although sex was not associated with the incidence of dysglycaemia, women and men showed differences in cardiometabolic risk factors related to glucose impairment: men who developed dysglycaemia showed, in parallel, higher LDL-c levels, TC/HDL-c ratio and DBP measurements; while these parameters remained similar between women who developed dysglycaemia and dysglycaemia-free women, after 5 years.

Conclusions
In an initially normoglycaemic sample of a highly mixed population living in a traditional Brazilian lifestyle, important cardiometabolic risk factors were associated with the occurrence of prediabetic dysglycaemia, and this relationship appeared to be more important in men. These results provide important insights about cardiovascular risk in prediabetic individuals.
Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation
Authors: Wan Yue-Meng , Li Zhi-qiang , Zhou Qiong , Liu Chang , Wang Men-Jie , Wu Hui-Xin , Mu Yun-Zhen , He Yue-Feng , Zhang Yuan , Wu Xi-Nan , Li Yu-Hua , Xu Zhi-Yuan , Wu Hua-Mei , Xu Ying , Yang Jin-Hui , Wang Xiao-Fang 
Published: January 2020

Abstract
Background
Mesenchymal stem cells (MSCs) are a population of pluripotent cells that might be used for treatment of liver disease. However, the efficacy of MSCs for mice with alcoholic hepatitis (AH) and its underlying mechanism remains unclear.

Methods
MSCs were isolated from the bone marrow (BM) of 4–6-week-old male C57BL/6 N mice. AH was induced in female mice by chronic-binge ethanol feeding for 10 days. The mice were given intraperitoneal injections of MSCs with or without transfection or AG490, recombinant mouse tumor necrosis factor (TNF)-α-stimulated gene/protein 6 (rmTSG-6), or saline at day 10. Blood samples and hepatic tissues were collected at day 11. Various assays such as biochemistry, histology, and flow cytometry were performed.

Results
MSCs reduced AH in mice, decreasing liver/body weight ratio, liver injury, blood and hepatic lipids, malondialdehyde, interleukin (IL)-6, and TNF-ɑ, but increasing glutathione, IL-10, and TSG-6, compared to control mice. Few MSCs engrafted into the inflamed liver. Knockdown of TSG-6 in MSCs significantly attenuated their effects, and injection of rmTSG-6 achieved similar effects to MSCs. The signal transducer and activator of transcription 3 (STAT3) was activated in mice with AH, and MSCs and rmTSG-6 inhibited the STAT3 activation. Injection of MSCs plus AG490 obtained more alleviation of liver injury than MSCs alone.

Conclusions
BM-MSCs injected into mice with AH do not engraft the liver, but they secrete TSG-6 to reduce liver injury and to inhibit STAT3 activation.
Surfactant protein D (SP-D) gene polymorphism rs721917 is an independent predictor of acute kidney injury development in sepsis patients: a prospective cohort study
Authors: Liu Jiao , Yao Jianying , Zhang Lidi , Chen Yizhu , Du Hangxiang , Wen Zhenliang , Chen Dechang 
Published: January 2020

Abstract
Background
Currently, there are no reliable predictors of risk of development and severity of acute kidney injury (AKI) in septic patients. The surfactant protein D (SP-D) polymorphism rs721917C/T is associated with a greater susceptibility to AKI in the Chinese population. Our aim was to evaluate the value of SP-D polymorphisms rs721917C/T and of plasma SP-D levels to predict the risk of development of AKI (defined with KDIGO criterion) in septic patients.

Methods
The study enrolled septic patients admitted to the Critical Care Department of two tertiary care hospitals. SP-D rs721917C/T polymorphisms were determined using the PCR-SSP method. Plasma SP-D and urine NGAL contents were measured using commercially available ELISA kits.

Results
330 septic patients were included. Their SOFA scores were 12 ± 3. Patients with AKI (n = 156) had higher plasma SP-D levels (median: 153 ng/mL, range 111–198 ng/mL) and urinary NGAL levels (median: 575 ng/mL, range 423–727 ng/mL) than those without AKI (SP-D median: 124 ng/mL, range 81–159 ng/mL, P = 0.001; NGAL median: 484 ng/mL, range 429–573 ng/mL). Plasma SP-D levels of AKI patients were correlated with urinary NGAL contents (r = 0.853). In 32 patients receiving continuous renal replacement therapy (CRRT), plasma SP-D levels correlated with duration of CRRT (r = 0.448). The area under the receiver operating characteristic curve for plasma SP-D levels to predict AKI was 0.84. Patients with AKI had a higher rate of rs721917 CC genotype (AKI: 35% vs. non-AKI: 20%; P = 0.012), but a significantly lower rate of TT genotype (AKI: 19% vs. non-AKI: 26%; P = 0.005). SP-D rs721917 CC genotype was an independent predictor of AKI (P = 0.044) and mortality (P = 0.014).

Conclusion
Our study showed that increased plasma SP-D level is associated with a higher risk of AKI in patients with sepsis. The SP-D rs721917CC genotype is an independent and significant predictor of AKI development and mortality of septic patients. The SP-D rs721917C/T polymorphisms should be further studied as diagnostic and prognostic biomarkers to facilitate early recognition of AKI.
Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections
Authors: Pouly Olivier , Lecailtel Sylvain , Six Sophie , Préau Sébastien , Wallet Frédéric , Nseir Saad , Rouzé Anahita 
Published: January 2020

AbstractBackgroundThe aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.MethodsThis retrospective study was performed in five 10-bed ICUs of a teaching hospital, during a 2-year period. Ventilator-associated lower respiratory tract infections (VA-LRTI), including ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) were prospectively diagnosed. The agreement between VAE, VAT and VAP was assessed by k statistics.ResultsA total of 1059 patients (15,029 ventilator-days) were included. 268 VAP (17.8 per 1000 ventilator-days), 127 VAT (8.5 per 1000 ventilator-days) and 262 VAE (17.4 per 1000 ventilator-days) were diagnosed. There was no agreement between VAT and VAE, and the agreement was poor between VAP and VAE (k = 0.12, 95% CI 0.03–0.20). VAE and VA-LRTI were associated with significantly longer duration of mechanical ventilation, ICU and hospital length of stay. VAP, VAT and VAE were not significantly associated with mortality in multivariate analysis.ConclusionsThe agreement was poor between VAE and VAP. No agreement was found between VAE and VAT. VAE episodes were significantly associated with longer duration of mechanical ventilation and length of stay, but not with ICU mortality.
Cache-aided mobile edge computing for B5G wireless communication networks
Authors: Xia Junjuan , Li Chao , Lai Xiazhi , Lai Shiwei , Zhu Fusheng , Deng Dan , Fan Liseng 
Published: January 2020

AbstractThis paper investigates a cache-aided mobile edge computing (MEC) network, where the source offloads the computation task to multiple destinations with computation capacity, with the help of a cache-aided relay. For the proposed cache-aided MEC networks, two destination selection criteria have been proposed to maximize the computation capacity of the selected destination, the channel gain of relay link and the channel gain of direct link, respectively. Similarly, three destination selection criteria have been proposed for the cache-free MEC networks based on the computation capacities of destinations and the channel gains of transmission links, respectively. To evaluate the system performance regarding the latency constraint, we provide the outage probability for the proposed network which is defined based on the transmission-plus-computation time. Our analysis suggests that caching can significantly alleviate the impact of increasing the size of computation task, since only half of the transmission time of cache-free network is required. However, the cache-aided network can not fully exploit the signal from both direct and relay links, thus the improvement by caching is less significant in the high signal-to-noise ratio (SNR) region, compared with the cache-free network employing the destination with maximal channel gain of direct link. Numerical results are given to validate our analysis.
Full-duplex decode-and-forward relaying with joint relay-antenna selection
Authors: Gilan Mahsa Shirzadian , Nguyen Ha H. 
Published: January 2020

AbstractThis paper is concerned with wireless relay networks that employ K full-duplex (FD) decode-and-forward relays to help a source to communicate with a destination. Each FD relay is equipped with multiple antennas, some for receiving and some for transmitting. The paper considers joint relay-antenna selection schemes that are based on the instantaneous channel conditions for two cases of antenna configurations, namely fixed antenna configuration (FAC) and adaptive antenna configuration (AAC). Under FAC, the transmit and receive antennas at each relay are fixed, whereas in the case of AAC an antenna at a relay can be configured to be either a transmit or a receive antenna.In addition to equal power allocation between the source and selected relay, a power scaling approach to counteract the effect of residual self-interference is also examined. Closed-form expressions of the outage probability and average capacity are obtained and provide important insights on the system performance. The accuracy of the obtained expressions are corroborated by simulation results. In particular, it is shown that under FAC and without power scaling, the diversity order approaches K as the self-interference (SI) level gets smaller, while it approaches zero whenever the SI level is nonzero and the SNR increases without bound. Under FAC and with power scaling, the diversity order approaches K for any SI level. For the case of AAC and without power scaling, the diversity order approaches 2K for small SI level. When power scaling is applied in AAC, the diversity order approaches 2K at any SI level.
On Cauchy–Schwarz inequality for N-tuple diamond-alpha integral
Authors: Hu Xi-Mei , Tian Jing-Feng , Chu Yu-Ming , Lu Yan-Xia 
Published: January 2020

AbstractIn this paper, we present some new Cauchy–Schwarz inequalities for N-tuple diamond-alpha integral on time scales. The obtained results improve and generalize some Cauchy–Schwarz type inequalities given by many authors.
An enhanced stability criterion for linear time-delayed systems via new Lyapunov–Krasovskii functionals
Authors: Duan Wenyong , Li Yan , Chen Jian 
Published: January 2020

AbstractThe stability problem of linear systems with time-varying delays is studied by improving a Lyapunov–Krasovskii functional (LKF). Based on the newly developed LKF, a less conservative stability criterion than some previous ones is derived. Firstly, to avoid introducing the terms with $h^{2}(t)$h2(t), which are not convenient to directly use the convexity of linear matrix inequality (LMI), the type of integral terms $\{\int _{s}^{t}\dot{x}(u)\,du, \int _{t-h}^{s}\dot{x}(u)\,du\}${∫stx˙(u)du,∫t−hsx˙(u)du} is used in the LKF instead of $\{\int _{s}^{t}x(u)\,du, \int _{t-h}^{s}x(u)\,du\}${∫stx(u)du,∫t−hsx(u)du}. Secondly, two couples of integral terms $\{\int _{s}^{t}\dot{x}(u)\,du, \int _{t-h(t)}^{s}\dot{x}(u)\,du\}${∫stx˙(u)du,∫t−h(t)sx˙(u)du}, and $\{\int _{s}^{t-h(t)}\dot{x}(u)\,du, \int _{t-h}^{s}\dot{x}(u)\,du\}${∫st−h(t)x˙(u)du,∫t−hsx˙(u)du} are supplemented in the integral functionals $\int _{t-h(t)}^{t}\dot{x}(u)\,du$∫t−h(t)tx˙(u)du and $\int _{t-h}^{t-h(t)}\dot{x}(u)\,du$∫t−ht−h(t)x˙(u)du, respectively, so that the time delay, its derivative, and information between them can be fully utilized. Thirdly, the LKF is further augmented by two delay-dependent non-integral items. Finally, three numerical examples are presented under two different delay sets, to show the effectiveness of the proposed approach.
RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR
Authors: Wan Xing , Song Yongxi , Fang Honghong , Xu Ling , Che Xiaofang , Wang Shuo , Zhang Xiaomeng , Zhang Lingyun , Li Ce , Fan Yibo , Hou Kezuo , Li Zhi , Wang Xueqing , Liu Yunpeng , Qu Xiujuan 
Published: January 2020

AbstractBackgroundThe incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor‐signaling pathways reportedly play key roles in the metastasis of malignant tumor cells. Receptor activator of nuclear factor κB ligand (RANKL) is a member of the tumor necrosis factor family, with strong chemokine‐like effects. Some studies have pointed out that the RANKL/RANK pathway is vital for the metastasis of cancer cells, but the specific mechanisms in GC remain poorly understood.ResultsThis study reports original findings in cell culture models and in patients with GC. Flow cytometry and western blotting analyses showed that RANK was expressed in BGC‐823 and SGC‐7901 cells in particular. Chemotaxis experiments and wound healing assay suggested that RANKL spurred the migration of GC cells. This effect was offset by osteoprotegerin (OPG), a decoy receptor for RANKL. RANKL contributed to the activation of human epidermal growth factor receptor (HER) family pathways. The lipid raft core protein, caveolin 1 (Cav‐1), interacted with both RANK and human epidermal growth factor receptor‐1(EGFR). Knockdown of Cav‐1 blocked the activation of EGFR and cell migration induced by RANKL. Moreover, RANK‐positive GC patients who displayed higher levels of EGFR expression had poor overall survival.ConclusionsIn summary, we confirmed that with the promotion of RANKL, RANK and EGFR can form complexes with the lipid raft core protein Cav‐1, which together promote GC cell migration. The formation of the RANK‐Cav‐1‐EGFR complex provides a novel mechanism for the metastasis of GC. These observations warrant confirmation in independent studies, in vitro and in vivo. They also inform future drug target discovery research and innovation in the treatment of GC progression.
Re-analysis of whole blastocysts after trophectoderm biopsy indicated chromosome aneuploidy
Authors: Ou Zhanhui , Chen Zhiheng , Yin Minna , Deng Yu , Liang Yunhao , Wang Wenjun , Yao Yuanqing , Sun Ling 
Published: January 2020

Abstract
Background
To compare the concordance between trophectoderm (TE) analysis and whole blastocyst analysis of embryos from chromosomal structural rearrangement (SR) carriers.

Method
Sixty-three abnormal blastocysts identified by preimplantation genetic testing for chromosomal structural rearrangement (PGT-SR) were included. The whole blastocysts were processed through multiple displacement amplification cycle and sequenced for 24-chromosome aneuploidy screening by next-generation sequencing (NGS). The sequencing results were compared with those of TE biopsy from the same blastocysts and the primary chromosomal rearrangement of the couples.

Results
Analysis of the 63 blastocysts showed 68% (43/63) complete concordance between TE sequencing analysis and whole blastocyst results. Approximately one third (20/63, 32%) of the sequencing results showed some level of discordance between the two samples. Of these, 14% (9/63) of the embryos were identified as euploid after whole blastocyst sequencing. Among them, seven blastocysts were classified as chromosome mosaicism (five whole chromosomes, two segmental) after TE analysis, while two displayed non-SR related segmental changes in the TE biopsy. Of the original analyses, 70% (44/63) of findings were associated with the primary parental chromosomal rearrangement, while 30% (19/63) had no association.

Conclusions
TE biopsy with NGS for PGT-SR is an efficient strategy to identify embryos suitable for transfer. While there was a high concordance between TE and whole blastocyst chromosome results, some embryos classified as mosaic in the original analysis and therefore unsuitable for transfer were reclassified as chromosomally balanced. To maximize the number of embryos available for PGT-SR patients, we suggest that embryos with mosaic non-SR chromosomal rearrangement should be stored and considered for transfer after appropriate counseling.
Researching social innovation: is the tail wagging the dog?
Authors: Rhule Emma L. M. , Allotey Pascale A. 
Published: January 2020

Abstract
Background
Social Innovation in health initiatives have the potential to address unmet community health needs. For sustainable change to occur, we need to understand how and why a given intervention is effective. Bringing together communities, innovators, researchers, and policy makers is a powerful way to address this knowledge gap but differing priorities and epistemological backgrounds can make collaboration challenging.

Main text
To overcome these barriers, stakeholders will need to design policies and work in ways that provide an enabling environment for innovative products and services. Inherently about people, the incorporation of community engagement approaches is necessary for both the development of social innovations and accompanying research methodologies. Whilst the 'appropriate' level of participation is linked to intended outcomes, researchers have a role to play in better understanding how to harness the power of community engagement and to ensure that community perspectives form part of the evidence base that informs policy and practice.

Conclusions
To effectively operate at the intersection between policy, social innovation, and research, all collaborators need to enter the process with the mindset of learners, rather than experts. Methods – quantitative and qualitative – must be selected according to research questions. The fields of implementation research, community-based participatory research, and realist research, amongst others, have much to offer. So do other sectors, notably education and business. In all this, researchers must assume the mantel of responsibility for research and not transfer the onus to communities under the guise of participation. By leveraging the expertise and knowledge of different ecosystem actors, we can design responsive health systems that integrate innovative approaches in ways that are greater than the sum of their parts.
The effect of transactional analysis on the self-esteem of imprisoned women: a clinical trial
Authors: Torkaman Mahya , Farokhzadian Jamileh , Miri Sakineh , Pouraboli Batool 
Published: January 2020

Abstract
Background
The imprisoned women usually have low self-esteem and suffer from various physical and mental complaints; they may suffer from feelings of emptiness, isolation, and depression. Transactional analysis (TA) is part of a comprehensive system attributed to the individual and social psychiatry for personal development of self-esteem among the imprisoned women. Therefore, the present study aimed to investigate the effect of TA group-training on the self-esteem of imprisoned women.

Methods
This clinical trial was conducted among the imprisoned women in a prison in Southeastern Iran using pretest-posttest design. In this regard, 76 women were randomly allocated to the intervention (n = 35) and control (n = 41) groups. The TA group-training program was held for eight 90-min sessions for the intervention group. Data were collected using a demographic questionnaire and the Rosenberg’s self-esteem scale (RSES). Later, all participants were evaluated before and 1 month after the intervention.

Results
In pre-test, the mean scores of self-esteem were 11.8 ± 4.67 and 7.97 ± 4.52 for the intervention and control groups, respectively. These scores showed low levels of self-esteem and the difference between the two groups was significant (p = 0.001, t = − 3.61). In the post-test, the mean scores of self-esteem improved to the moderate level (22 ± 2.52) in the intervention group compared to the control group (8.92 ± 4.04). This indicates the significant improvement of self-esteem in the intervention group (p = 0.001, t = 17.15).

Conclusions
The results showed that TA group-training had a significant effect on self-esteem. Therefore, the experienced and expert counselors and psychologists are recommended to hold transactional analysis group-training courses to enhance self-esteem among women prisoners.

Trial registration
Iranian Registry of Clinical Trials, IRCT20170725035289N5 Date registered: 25/08/2018.
The effect of antithrombin added to recombinant human-soluble thrombomodulin for severe community-acquired pneumonia-associated disseminated intravascular coagulation: a retrospective cohort study using a nationwide inpatient database
Authors: Suzuki Jun , Sasabuchi Yusuke , Hatakeyama Shuji , Matsui Hiroki , Sasahara Teppei , Morisawa Yuji , Yamada Toshiyuki , Yasunaga Hideo 
Published: January 2020

Abstract
Background
Studies showed potential benefits of recombinant human-soluble thrombomodulin (rhTM) and antithrombin for treating sepsis associated disseminated intravascular coagulation. However, benefits of their combination have been inconclusive.

Methods
Using a nationwide inpatient database in Japan, we performed propensity-score matched analyses to compare outcomes between rhTM combined with antithrombin and rhTM alone for severe community-acquired pneumonia associated disseminated intravascular coagulation from July 2010 to March 2015. The outcomes included in-hospital mortality and requirement of red cell transfusion.

Results
Propensity score matching created 189 pairs of patients who received rhTM combined with antithrombin or rhTM alone within 2 days of admission. There was no significant difference between the two groups for in-hospital mortality (40.2% vs. 45.5%). Patients treated with rhTM and antithrombin were more likely to require red cell transfusion than those treated with rhTM alone (37.0% vs. 25.9%).

Conclusions
Compared with rhTM alone, combination of rhTM with antithrombin for severe community-acquired pneumonia-associated disseminated intravascular coagulation may be ineffective for reducing mortality and may increase bleeding.