bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective evaluation of flow cytometric characteristics, histopathologic diagnosis and clinical outcome in dogs with naïve B‐cell lymphoma treated with a 19‐week CHOP protocol
Authors: Wolf‐Ringwall Amber , Lopez Lynelle , Elmslie Robyn , Fowler Brooke , Lori Janet , Sfiligoi Gabriella , Skope Anne , Arnold Erin , Hughes Kelly L. , Thamm Douglas H. , Ehrhart E. J. , Avery Anne C. , Lana Susan E. 
Published: November 2019

AbstractCanine B‐cell lymphoma is a clinically heterogenous disease; however, it is generally treated as a single disease entity. The purpose of this clinical trial was to prospectively evaluate naïve canine B‐cell lymphoma patients using histopathology, flow cytometry (FC) and a standardized chemotherapy protocol to better define subsets of this disease that may respond differently to treatment. Sixty‐four dogs with naïve multicentric B‐cell lymphoma were treated with a standardized 19‐week CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy protocol. Most of the dogs (84.3%) were diagnosed with diffuse large B‐cell lymphoma (DLBCL), followed by nodal marginal zone (7.8%), small B‐cell (4.7%), Burkitt‐like (1.6%) and follicular lymphoma (1.6%). FC confirmed the diagnosis of B‐cell lymphoma in all cases. There were no clear phenotyping differences between the subtypes of B‐cell lymphoma detectable by our FC panel. The histologic subtypes in this study exhibited a range of forward scatter values on flow cytometry, but all of the DLBCL cases were higher than a value of 469, while the only cases with a lower forward scatter value were follicular lymphoma and diffuse small B‐cell lymphoma. Dogs with DLBCL had a significantly better objective response rate to the CHOP protocol (96.3%) than the non‐DLBCL subtypes (70%, P = .024). The median progression‐free survival time for patients with DLBCL (233 days) was significantly longer than that of all other histopathologic subgroups combined (163 days, P = .0005).
Molecular phylogeny and host‐plant use (Lamiaceae) of theThymogethespollen beetles (Coleoptera)
Authors: Sabatelli Simone , Liu Meike , Badano Davide , Mancini Emiliano , Trizzino Marco , Richard Cline Andrew , Endrestøl Anders , Huang Min , Audisio Paolo 
Published: November 2019

AbstractThe 24 members of the Euro‐Asiatic genusThymogethesare highly specialized pollen beetles associated as larvae with flowers of Lamiaceae Nepetoideae. All members of the genus were analysed in within the framework of an integrative taxonomy approach, which was aimed to reconstruct the phylogenetic relationships, as well as the possible pattern of evolution of their larval‐host‐plant association. Evidence from multiple molecular markers [COI; 16S; H3], combined with an estimation of divergence times using an average rate of 0.0177 substitutions/site/My among branches, placed the origin of the genus at a minimum of 9–10 Mya. This date of origin approximates the known evolution of the host plants in Euro‐Mediterranean areas. Evidence from combined molecular and cladistic morphological analyses resulted in suitable agreement with the previously established morphology‐based systematics of the genus, although members of theexilisspecies‐group were split into three clades. The only disagreement between results of this new combined phylogeny and previous classification is in the exclusion of “Thymogethes”grenieri. This species is herein positioned outside the genus, based on molecular evidence. Our analysis depicts severalThymogethesspecies differentiating in the last few Mys, specifically those included in theT. lugubrisspecies‐group. Combined evidence from DNA, morphology and ancestral state parsimony reconstruction of larval‐host‐plant associations suggests that subtribe Menthinae likely represents the ancestral host plants, with a series of independent host shifts during the radiation of the clade, in association first with Menthinae and subsequently with Lavandulinae and Nepetinae. Steno‐oligophagy is the most frequent (86%) condition, while strictly monophagous species are less numerous (14%).
Three-Dimensional Modeling of Wave-Induced Seabed Response Around a Semi-Buried Pipeline: A Small-Scale Case
Authors: Zhu Jianfeng , Zhao Hongyi 
Published: November 2019

Abstract
In this paper, a three-dimensional integrated numerical model for a small-scale case of wave-induced oscillatory soil response around a semi-buried pipeline (PORO-WSSI-PIPE 3D) is proposed. In this model, we combine the Reynolds-averaged Navier–Stokes (RANS) equations for the 3D wave motions and the Biot’s consolidation equations for a porous elastic seabed foundation through pressure continuity at common boundaries, with pipeline being an elastic and impermeable medium. The computational results are validated through comparison with previous analytical solutions and laboratory wave flume tests, obtaining good agreement. Following validation, the numerical model is applied to simulate wave-seabed-pipeline interaction with different obliquities between pipeline and incident wave, varying from 30 deg to 90 deg. Snapshots of wave-seabed-pipeline interaction, as well as dynamic pore pressure distributions at typical locations in the vicinity of a semi-buried pipeline, are obtained and analyzed. The three-dimensional consolidation process of seabed under gravitational forces including the body forces of a pipeline is also discussed.
Design of Mooring Solutions and Array Systems for Point Absorbing Wave Energy Devices—Methodology and Application
Authors: Ringsberg Jonas W. , Jansson Hanna , Örgård Martin , Yang Shun-Han , Johnson Erland 
Published: November 2019

Abstract
Most of the ocean energy technologies are considered to be in a pre-commercial phase and need technical development. This study focuses on the design of mooring solutions and compares array systems of a specific floating point-absorbing wave energy converter (WEC) developed by the company Waves4Power. A full-scale prototype of the WEC is installed in Runde (Norway) where it is moored with three polyester mooring lines, each having one floater and one gravity anchor. Based on this reference installation, the method of systems engineering was used to propose 22 conceptual mooring solutions for different array systems. They were compared and reduced to four top concepts in a systematic elimination procedure using Pugh and Kesselring matrices. The top concepts were assessed in detail by means of levelized cost of energy (LCOE), life cycle analysis (LCA), and risk analyses. The fatigue life of the mooring lines and the energy capture were calculated using results obtained from coupled hydrodynamic and structure response analyses in the dnv-gl deepc software. Two final concepts were proposed for the water depths 75 and 200 m.
Integrity Management of Offshore Structures With Emphasis on Design for Structural Damage Tolerance
Authors: Moan Torgeir 
Published: November 2019

AbstractBased on relevant accident experiences with oil and gas platforms, structural integrity management of offshore structures is briefly outlined, including adequate design criteria, fabrication and operational procedures, as well as life cycle quality assurance and control. The focus is on developing an operational design standard for accidental collapse limit states to ensure robustness or damage tolerance. The focus is to ensure an acceptable safety level against progressive failure leading to total loss in view of initial damage caused by accidental actions due to operational errors and abnormal structural damage due to fabrication errors and abnormal deterioration during operation as well as the actions on the damaged structure and inherent uncertainties. Moreover, the damage tolerance required for achieving safety by inspection, monitoring and repair strategies, is briefly addressed. While the basic damage tolerance requirement refers to the survival of the structure in certain damage conditions, wider aspects of robustness in terms of the structure’s sensitivity to the deviation of action effects and resistances from normal conditions are also briefly addressed. In particular, it is suggested to provide robustness in cases where the structural performance is sensitive to uncertain parameters, by choosing conservative values of these parameters.
Structural Reliability of Oil Tanker in the Adriatic Sea Damaged in Collision and Exposed to Combined Bending Moments
Authors: Ćorak Maro , Parunov Joško 
Published: November 2019

AbstractThe aim of the paper is the assessment of structural reliability of oil tanker, damaged in collision accident in the Adriatic Sea and exposed to combined, horizontal, and vertical bending moments. Damage size is assumed based on the direct numerical simulation of the ship–ship collision. This is justified for some specific sea environments, as the Adriatic Sea, where ship sailing routes and representative ship types involved in accidents are known, so possible collision scenarios may be reasonably predicted. Residual bending moment capacity under combined bending moments (CBM) is calculated using regression equations developed based on non-linear finite element analysis. Still-water vertical bending moments are obtained by damage stability analysis for different collision scenarios that are generated by Monte Carlo (MC) simulations. Vertical and horizontal wave bending moments are determined by short-term response analysis of damaged ship in the Adriatic Sea, using transfer functions obtained by 3D panel hydrodynamic method. Monte Carlo time simulations are performed in order to study probabilistic load combination (LC) considering randomness of the wave process due to different phase angles. Limit state function is defined using interaction equation for damaged ship exposed to combined bending moments. Safety indices are calculated by FORM for each damage scenario by using Turkstra's rule for load combination of vertical and horizontal wave bending moments. Such an approach enables to determine the safety indices for the most frequent damages and also to reveal the most critical situations resulting in the lowest safety indices.
Thermal-Fluid-Solid Coupling in Thermal Characteristics Analysis of Rolling Bearing System Under Oil Lubrication
Authors: Hao Xu , Yun Xianghe , Han Qingkai 
Published: November 2019

Abstract
It is necessary to use the thermal network method for thermal analysis of the bearing, but there are still some shortcomings. In this paper, a novel thermal network model of the bearing transient temperature is developed considering the thermal-fluid-solid coupling effects. First, the quasi-static analysis of the bearing is carried out considering the thermal expansion effect, and the heat generation, heat transfer, and heat dissipation are studied. Then, the coupling effects between the oil characteristics, heat generation, structure parameters, and temperature (thermal-fluid-solid) during the operation of the bearing are discussed, and the transient thermal network model of the bearing-shaft-bearing housing system is established. Test results indicate that the existing models (without thermal-fluid-solid coupling) have large temperature deviation, while the proposed model in this paper considering the thermal-fluid-solid coupling effects is much more accurate. Finally, the effects of rotational speed, load, oil temperature, and oil flowrate on the temperature rise are all achieved and discussed.
Experimental Investigation on Two-Body Abrasion of Cast Aluminum–Alumina Composites: Influence of Abrasive Size and Reinforcement Content
Authors: Sardar Santanu , Karmakar Santanu Kumar , Das Debdulal 
Published: November 2019

Abstract
The occurrence of abrasion is inevitable in most engineering systems. Abrasive wear specifically two-body causes higher material and dimensional loss than other modes of wear. Two-body abrasion is yet to be fully comprehended as it is governed by several intrinsic and extrinsic variables. In this article, tribo-performances of Al-composites were experimentally studied with specific emphasis on the role of abrasive size and amount of reinforcement. AA7075 alloy matrix composites with different amounts of alumina particles were fabricated by the advanced stir-casting method. Besides measurements of density, porosity, and Vickers hardness, in-depth characterizations of microstructures were performed. Specific wear-rate (SWR), coefficient of friction (COF), and abraded surface roughness (SR) of developed materials were measured under two-body abrasion over a vast range of distance, load, velocity, and abrasive size. Under all abrasion conditions, composites exhibited higher SR but lower SWR and COF over alloy; the differences increased with reinforcement quantity. SWR, COF, and SR rose with an increase in abrasive size; however, only SR varied with sliding distance for any material. The effects of different variables on the recorded tribo-performances were explained through identification of various micro-mechanisms of abrasion via extensive post wear characterizations and microstructural features. Finally, the criteria for the occurrence of three-body abrasion even in two-body test configuration were highlighted. The wear coefficient value of 10 × 10−3 was identified as the demarcation between two-body and two-body plus three-body abrasion for Al-matrix composites.
Conceptual Design of Oblong Ring Vibrators
Authors: Thomas G. P. L. , Kiyono C. Y. , Gay Neto A. , Silva E. C. N. 
Published: November 2019

Abstract
An oblong ring-type structure is composed by two straight segments (length L) and two semicircular segments (radius R). It can be used to generate traveling waves, being applied to build linear piezoelectric motors and linear conveyor systems. The traveling waves to such applications occur at specific frequencies, generated by simultaneous symmetric and antisymmetric flexural vibration modes which, in general, have distinct natural frequencies. However, for specific designs, they may coincide or be very close. This may be achieved by finding the appropriate L/R ratio. For preliminary design, an analytical model is very desirable, due to its computational efficiency and the absence of a computational automatic identification of symmetric and antisymmetric flexural vibration modes among numerical solutions. Therefore, the objective of this work is to propose an analytical and practical model to determine classes of vibration modes of interest for producing traveling waves in oblong ring-type structures, being employed for conceptual design such that the L/R ratio is determined in an efficient way. The oblong ring is considered as a beam-like structure composed by straight and curved segments, employing Timoshenko and Euler–Bernoulli kinematic assumptions. A design method is proposed by solving sequentially and systematically distinct geometric proposals of oblong ring-type designs and, for each one, evaluating the candidates to produce the flexural traveling waves. Later, the strong-candidates are analyzed by finite element models to test the quality of the design with less assumptions. We show that the methodology provides convenient results as a design method for oblong ring-type structures.
Structural modeling of the Western Transverse Ranges: An imbricated thrust ramp architecture
Authors: Levy Y. , Rockwell T.K. , Shaw J.H. , Plesch A. , Driscoll N.W. , Perea H. 
Published: November 2019

AbstractActive fold-and-thrust belts can potentially accommodate large-magnitude earthquakes, so understanding the structure in such regions has both societal and scientific importance. Recent studies have provided evidence for large earthquakes in the Western Transverse Ranges of California, USA. However, the diverse set of conflicting structural models for this region highlights the lack of understanding of the subsurface geometry of faults. A more robust structural model is required to assess the seismic hazard of the Western Transverse Ranges. Toward this goal, we developed a forward structural model using Trishear in MOVE® to match the first-order structure of the Western Transverse Ranges, as inferred from surface geology, subsurface well control, and seismic stratigraphy. We incorporated the full range of geologic observations, including vertical motions from uplifted fluvial and marine terraces, as constraints on our kinematic forward modeling. Using fault-related folding methods, we predicted the geometry and sense of slip of the major faults at depth, and we used these structures to model the evolution of the Western Transverse Ranges since the late Pliocene. The model predictions are in good agreement with the observed geology. Our results suggest that the Western Transverse Ranges comprises a southward-verging imbricate thrust system, with the dominant faults dipping as a ramp to the north and steepening as they shoal from ∼16°–30° at depth to ∼45°–60° near the surface. We estimate ∼21 km of total shortening since the Pliocene in the eastern part of the region, and a decrease of total shortening west of Santa Barbara down to 7 km near Point Conception. The potential surface area of the inferred deep thrust ramp is up to 6000 km2, which is of sufficient size to host the large earthquakes inferred from paleoseismic studies in this region.
Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding
Authors: Jensen Erik A , Zhang Huayan , Feng Rui , Dysart Kevin , Nilan Kathleen , Munson David A , Kirpalani Haresh 
Published: November 2019

ObjectiveCompare rates of hypoxaemia during transpyloric and gastric feedings in very preterm infants with severe bronchopulmonary dysplasia.DesignN-of-1 multiple crossover trials with individual patient and pooled data analyses.SettingLevel IV intensive care nursery.PatientsInfants receiving positive airway pressure between 36 and 55 weeks postmenstrual age were enrolled between December 2014–July 2016.InterventionN-of-1 trial consisting of two blocks, each with a 4-day gastric and 4-day transpyloric feeding period assigned in random order.Main outcome measuresThe primary outcome was the frequency of daily intermittent hypoxaemic events (SpO2≤80% lasting 10–180 s). Secondary outcomes included the daily proportion of time with an SpO2≤80% and mean daily fraction of inspired oxygen.ResultsOf 15 infants, 13 completed the trial and 2 stopped early for transient worsening in respiratory status during gastric feedings. In the intention-to-treat analyses, transpyloric feedings resulted in increased rates of intermittent hypoxaemia in five infants, greater time per day in hypoxaemia in three infants and more supplemental oxygen use in three infants. One infant received more supplemental oxygen during gastric feedings. The remaining study outcomes were similar between the feeding routes in all other infants. Pooling all data, transpyloric feedings resulted in a higher frequency of intermittent hypoxaemic events (median 7.5/day (IQR 1–23.5) vs 3/day (1–11); adjusted incidence rate ratio 1.8, 95% CI 1.3 to 2.5) and a greater proportion of daily hypoxaemia time (median 0.8% (IQR 0.1–2.3) vs 0.4% (0.07–1.8); adjusted mean difference 1.6, 95% CI 1.1 to 2.5).ConclusionsTranspyloric compared with gastric feedings modestly increased rates of hypoxaemia among study participants.Trial registration numberNCT02142621
Telephone or internet delivered talking therapy can alleviate irritable bowel symptoms
Authors: Cook Rob , Davidson Peter , Martin Rosie 
Published: November 2019

The studyEveritt H, Landau G, Little P. Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT. Health Technol Assess 2019;23:1-154.This project was funded by the NIHR Health Technology Assessment Programme (project number 11/69/02).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000784/irritable-bowel-syndrome-helped-by-telephone-or-internet-cbt
Antimicrobial central venous catheters do not reduce infections in pre-term babies
Authors: Cook Rob , Fortescue-Webb Duncan , Martin Rosie 
Published: November 2019

The studyGilbert R, Brown M, Rainford N et al. Antimicrobial-impregnated central venous catheters for prevention of neonatal bloodstream infection (PREVAIL): an open-label, parallel-group, pragmatic, randomised controlled trial. Lancet Child Adolesc Health 2019;3:381-90.The study was funded by the NIHR Health Technology Assessment programme (project number 12/167/02).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000782/antimicrobial-central-venous-catheters-for-pre-term-babies-do-not-reduce-infections
Prevalence and correlates of alcohol and tobacco use among key populations in Togo in 2017: a cross-sectional study
Authors: Bitty-Anderson Alexandra Marie , Gbeasor-Komlanvi Fifonsi Adjidossi , Johnson Pascal , Sewu Essèboè K , Dagnra Claver A , Salou Mounerou , Blatome Tetouyaba J , Jaquet Antoine , Coffie Patrick Ahuatchi , Ekouevi Didier Koumavi 
Published: November 2019

ObjectivesThe aim of this study was to estimate alcohol and tobacco use prevalence and their correlates among female sex workers (FSW), men who have sex with men (MSM) and drug users (DU) in Togo.Design, setting and participantsA cross-sectional bio-behavioural study was conducted among 2115 MSM, FSW and DU in 2017 using a respondent-driven sampling method, in the eight biggest towns of Togo. Selection criteria for the MSM were being male and having had oral or anal intercourse with a man in the previous 12 months; for FSW, being a female and having exchanged sex for money in the previous 12 months; and for DU, consuming heroin, cocaine or hashish for MSM, FSW and DU, respectively. All participants had to be at least 18 years old and residing in the territory for the past 3 months.ResultsThe prevalence of alcohol consumption, hazardous/harmful consumption and binge drinking was 64.8%, 38.4% and 45.5%, respectively. Current tobacco use was reported by 30.6% of participants and HIV prevalence was estimated at 12.5%. DU were more likely to engage in binge drinking compared with other key populations (adjusted odds ratio (aOR)=2.0; 95% CI 1.4 to 2.8; p=0.001). Participants who were identified as having hazardous/harmful alcohol consumption had almost three times the odds of tobacco consumption than those with no risky consumption (aOR=2.6; 95% CI 2.0 to 3.4; p=0.001). Hazardous/harmful alcohol consumption was three times more likely among participants with severe psychological distress compared with those with no psychological distress (aOR=3.3, 95% CI 2.2 to 5.1; p=0.001).ConclusionFindings from this study demonstrate the need for the integration of mental health and substance abuse reduction interventions into HIV prevention programme, particularly those geared towards key populations.