bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the vestibular system in value attribution to positive and negative reinforcers
Authors: Blini Elvio , Tilikete Caroline , Chelazzi Leonardo , Farnè Alessandro , Hadj-Bouziane Fadila 
Published: May 2020

AbstractSomatic inputs originating from bioregulatory processes can guide cognition and behavior. One such bodily signal, mostly overlooked so far, is represented by visuo-vestibular coupling and its alteration, which in extreme cases may result in motion sickness. We argued that the inherently perturbed interoceptive state that follows can be a powerful determinant of human motivated behavior, resulting in a blunted response to appetitive stimuli and an exaggerated response to noxious ones. We sought to assess such differential impact of visuo-vestibular mismatches on value through a task involving conflict monitoring. We therefore administered to 42 healthy participants a modified version of the Flankers task, in which distractors (arrows, pointing in either a congruent or incongruent direction) signaled the availability of monetary incentives (gains, losses, or neutral trials). While performing the task, participants received either galvanic vestibular stimulation (GVS), or sham stimulation. We have found impaired behavioral performances when value, which was attached to task-irrelevant information, was at stake. Gains and losses, interestingly, dissociated, and only the latter caused enhanced interference costs in the task, suggesting that negative incentives may be more effective in capturing human attention than positive ones. Finally, we have found some weak evidence for GVS to further increase the processing of losses, as suggested by even larger interference costs in this condition. Results were, however, overall ambiguous, and suggest that much more research is needed to better understand the link between the vestibular system and motivation.HighlightsVisuo-Vestibular mismatches may be important somatic markers affecting the evaluation of reinforcers;When attached to distractors, value information impairs behavioral performance for the task at hand;Trials in which potential losses were at stake were associated with larger interference costs arising from conflicting information between the target and the flankers;GVS (Right-Anodal) may further increase the interference caused by losses, but the evidence in this respect was ambiguous and inconclusive;
Identification of five antiviral compounds from the Pandemic Response Box targeting SARS-CoV-2
Authors: Holwerda Melle , V’kovski Philip , Wider Manon , Thiel Volker , Dijkman Ronald 
Published: May 2020

AbstractWith currently over 4 million confirmed cases worldwide, including more than 300’000 deaths, the current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has a major impact on the economy and health care system. Currently, a limited amount of prophylactic or therapeutic intervention options are available against SARS-CoV-2. In this study, we screened 400 compounds from the antimicrobial ‘Pandemic Response Box’ library for inhibiting properties against SARS-CoV-2. We identified sixteen compounds that potently inhibited SARS-CoV-2 replication, of which five compounds displayed equal or even higher antiviral activity compared to Remdesivir. These results show that five compounds should be further investigated for their mode of action, safety and efficacy against SARS-CoV-2.Highlights400 compounds from the pandemic response box were tested for antiviral activity against SARS-CoV-2.5 compounds had an equal or higher antiviral efficacy towards SARS-CoV-2, compared to the nucleoside analogue Remdesivir.
Objective Extraction of Evoked Event-related Oscillations from Time-frequency Representation of Event-related Potentials
Authors: Zhang Guanghui , Ristaniemi Tapani , Cong Fengyu 
Published: May 2020

AbstractEvoked event-related oscillations (EROs) have been widely used to explore the mechanisms of brain activities for both normal people and neuropsychiatric disease patients. The selection of regions of evoked EROs tends to be subjectively based on the previous studies and the visual inspection of grand averaged time-frequency representations (TFRs) which causes some missing or redundant information. Meanwhile, the evoked EROs cannot be fully extracted via the conventional time-frequency analysis (TFA) method because they are sometimes overlapped with each other or with artifacts in time, frequency, and space domains to some extent. Hence, these shortcomings may pose some challenges to investigate the related neuronal processes. A data-driven approach was introduced to fill the gaps as below: extracting the temporal and spatial components of interest simultaneously by principal component analysis and Promax rotation and projecting them to the electrode field to correct their variance and polarity indeterminacy, calculating the TFRs of the back-projected components, and determining the regions of interest objectively using the edge detection algorithm. We performed this novel approach and the conventional TFA method in analyzing both a synthetic dataset and an actual ERP dataset in a two-factor simple gambling paradigm of waiting time (short/long) and feedback (loss/gain) separately. Synthetic dataset results indicated that N2-theta and P3-delta oscillations were detected using the proposed approach, but, by comparison, only one oscillation was obtained via the conventional TFA method. Furthermore, the actual ERP dataset results of P3-delta for our approach revealed that it was sensitive to the waiting time (which also was found in the previous reports) but not for that of the conventional TFA method. This study manifested that the proposed approach can objectively extract evoked EROs, which allows a better understanding of the modulations of the oscillatory responses.
A Feedforward Loop Governs The Relationship Between Lipid Metabolism And Longevity
Authors: Littlejohn Nicole K. , Seban Nicolas , Srinivasan Supriya 
Published: May 2020

SUMMARYThe relationship between lipid metabolism and longevity remains unclear. In particular although fat oxidation is essential for weight loss, whether it is remains beneficial when sustained for long periods, and the extent to which it may alter lifespan remains an important unanswered question. Here we develop an experimental handle in theC. elegansmodel system, that uncovers the mechanisms that connect long-term fat oxidation with longevity. We find that sustained □-oxidation, via activation of the conserved triglyceride lipase ATGL-1, triggers a feedforward transcriptional loop that involves the mito-nuclear transcription factor ATFS-1, and a previously unknown and highly conserved repressor of ATGL-1 called HLH-11/AP4. This feedforward loop orchestrates the dual control of fat oxidation and lifespan protection, shielding the organism from life-shortening mitochondrial stress in the face of continuous fat oxidation. Thus, we uncover one mechanism by which fat oxidation can be sustained for long periods without deleterious effects on longevity.
The naked cell: emerging properties of a surfome-streamlinedPseudomonas putidastrain
Authors: Martínez-García Esteban , Fraile Sofía , Espeso David Rodríguez , Vecchietti Davide , Bertoni Giovanni , de Lorenzo Víctor 
Published: May 2020

ABSTRACTEnvironmental bacteria are most often endowed with native surface-attachment programs that frequently conflict with efforts to engineer biofilms and synthetic communities with given tridimensional architectures. In this work we report the editing of the genome ofPseudomonas putidaKT2440 for stripping the cells of most outer-facing structures of the bacterial envelope that mediate motion, binding to surfaces and biofilm formation. To this end, 23 segments of theP. putidachromosome encoding a suite of such functions were deleted, resulting in the surface-naked strain EM371, the physicochemical properties of which changed dramatically in respect to the wild type counterpart. As a consequence, surface-editedP. putidacells were unable to form biofilms on solid supports and—because of the swimming deficiency and other physicochemical alterations—showed a much faster sedimentation in liquid media. Surface-naked bacteria were then used as carriers of interacting partners (e.g. Jun-Fos domains) ectopically expressed by means of an autotransporter display system on the now easily accessible cell envelope. Abstraction of individual bacteria as adhesin-coated spherocylinders enabled rigorous quantitative description of the multi-cell interplay brought about by thereby engineered physical interactions. The model was then applied to parameterize the data extracted from automated analysis of confocal microscopy images of the experimentally assembled bacterial flocks for analyzing their structure and distribution. The resulting data not only corroborated the value ofP. putidaEM371 over the parental strain as a platform for display artificial adhesins but also provided a strategy for rational engineering of distributed biocatalysis.
Payload parameter identification method of flexible space manipulator
Authors: Ni Zhiyu , Zhang Yewei , Shen Xinhui , Wu Shunan , Wu Zhigang 
Published: May 2020

Purpose
When a manipulator captures an unknown space object, inertia parameters of endpoint payload should be timely obtained to handle possible unexpected parameter variations and monitor the system’s operating conditions. Therefore, this study aims to present an identification method for estimating the inertia parameter of the payload carried by a flexible two-link space manipulator.

Design/methodology/approach
The original nonlinear dynamics model of the manipulator is linearized at a selected working point. Subsequently, the system modal frequencies with and without payload are determined using the subspace identification algorithm, and the difference of these frequencies is computed. Furthermore, by adjusting the structural configuration of the manipulator, multiple sets of frequency differences are obtained. Therefore, the inertia parameters of the payload, i.e. the mass and the moment of inertia, can be derived from the frequency differences by solving a least-squares problem.

Findings
The proposed method can effectively estimate the payload parameters and has satisfactory identification accuracy.

Practical implications
The approach’s implementation provides a practical reference for determining inertia parameters of an unknown space target in the capture process.

Originality/value
The study proposes a novel method for identifying the inertia parameters of the payload of a flexible two-link space manipulator using the estimated system frequencies.
Identification and analysis of enablers of SCM by using MCDM approach
Authors: Agrawal Vivek , Mohanty Rajendra P. , Agrawal Anand Mohan 
Published: May 2020

PurposeThe purpose of this paper is to differentiate the empowering influences of critical enablers of supply chain management (SCM) along with their interrelationships. These empowering enablers are significant, as they encourage productive execution to improve organizational performance and stakeholder's satisfaction.Design/methodology/approachFrom the literature review, incidence of a number of SCM enablers were found and they were subjected to critical scrutiny by a considerable number of experts engaged in SCM research and application to identify significant and applicable empowering enablers by grounded interactions. By using Impact Matrix Cross-Reference Multiplication Applied to a Classification analysis, the driving and dependence power were analyzed and the empowering enablers were ordered. This was pursued by building up a structural model of the empowering enablers using interpretive structure modeling, followed with measuring cause–effect relationship using decision-making trial and evaluation laboratory (DEMATEL).FindingsAmong these identified enablers of SCM, operational performance, green SCM, employee empowerment and motivation and strategic association came out to be strategic enablers.Research limitations/implicationsThe findings may help the practicing professionals to develop clarity in understanding of these essential enablers and their contextual as well as cause–effect relationship in SCM. The practicing professionals need to focus on all these enablers during implementation of SCM for enhancing the organizational performance and stake holders' satisfaction.Originality/valueThis study is of practical utility in real-life implementation of SCM. The algorithm used in applying the multi-criteria decision-making approach is very user-friendly, and the application of DEMATEL is an innovation compared to previous research. Further, the findings can be used as a benchmark for improving the performance of SCM by considering the cause–effect relationship.
Technological capability dynamics through cluster organizations
Authors: Lis Anna Maria , Rozkwitalska Malgorzata 
Published: May 2020

PurposeThe purpose of the paper is to portrait how members of cluster organizations (COs) perceive the role of COs in enabling them to accumulate technological capability (TC) significant for their innovation.Design/methodology/approachThe authors report the findings from their qualitative study based on an analysis of four COs. The organizational inertia and absorptive capacity theories are the theoretical underpinning of the research.FindingsThe study shows that the dynamics of TC of the cluster companies included in the study sample relates to their initial level of TC and cluster cooperation. The companies with relatively low initial TC increase it through COs if the clusters offer comparatively high benefits. On the other hand, those COs' members that present relatively high initial TC advance it, provided that the external knowledge and other benefits they can absorb in their clusters are suited to their technological trajectories.Research limitations/implicationsThe research is preliminary in nature and portrays how firms with different levels of TC cooperate within COs and how this cooperation translates into TC improvements. The findings add to the state-of-the-art knowledge on the link between TC and absorptive capacity of companies involved in COs by depicting the role of COs in providing knowledge and other cluster benefits that help cluster companies to accumulate TC and improve their absorptive capacity. Nevertheless, the applied methodology does not allow the authors to generalize the findings.Practical implicationsThe coordinators of COs should skillfully shape the levels of cluster cooperation, matching them to the desired level of the cluster companies. They should create smaller subgroups composed of companies with similar TC, which may translate into its higher dynamic.Originality/valueThe knowledge about the role of COs in providing cluster benefits that help cluster companies to accumulate TC and improve their absorptive capacity is still insufficient. The study shed new light on the key role of the levels of cluster cooperation and the types of commitment related to them (i.e. technological effort), which may be a matter of importance in the dynamics of TC accumulation.
Dynamic output feedback control for nonlinear large-scale interconnected systems
Authors: Touti Ezzeddine , Tlili Ali Sghaier , Almutiry Muhannad 
Published: May 2020

Purpose
This paper aims to focus on the design of a decentralized observation and control method for a class of large-scale systems characterized by nonlinear interconnected functions that are assumed to be uncertain but quadratically bounded.

Design/methodology/approach
Sufficient conditions, under which the designed control scheme can achieve the asymptotic stabilization of the augmented system, are developed within the Lyapunov theory in the framework of linear matrix inequalities (LMIs).

Findings
The derived LMIs are formulated under the form of an optimization problem whose resolution allows the concurrent computation of the decentralized control and observation gains and the maximization of the nonlinearity coverage tolerated by the system without becoming unstable. The reliable performances of the designed control scheme, compared to a distinguished decentralized guaranteed cost control strategy issued from the literature, are demonstrated by numerical simulations on an extensive application of a three-generator infinite bus power system.

Originality/value
The developed optimization problem subject to LMI constraints is efficiently solved by a one-step procedure to analyze the asymptotic stability and to synthesize all the control and observation parameters. Therefore, such a procedure enables to cope with the conservatism and suboptimal solutions procreated by optimization problems based on iterative algorithms with multi-step procedures usually used in the problem of dynamic output feedback decentralized control of nonlinear interconnected systems.
The global internet market(s): a reconstruction of the views of the industry
Authors: Simon Jean Paul 
Published: May 2020

Purpose
This paper aims to provide a synthesis of the evolution of the global internet markets through an assessment of their economic strength. It is an attempt to describe the various segments of the internet value chain and the evolution of the markets. It aims at briefly summing up the very dynamics of the sector, of the various subsectors while looking at the business models and the market capitalization.

Design/methodology/approach
The paper is a descriptive paper, presenting market trends, based on desk research and trade press. It is not meant to provide any theoretical contribution but attempting to reconstruct the views from the industry as documented by trade literature. Hence, the paper relies mostly on industry and consultancy data. The paper builds on a database collected by the author over the past 30 years and the selection of the relevant data to document and identify the trends and offer a synthesis of the views of the industry.

Findings
The paper shows how over the past 30 years the internet has changed dramatically from both a quantitative (reaching more and more users worldwide and witnessing a dramatic growth of all markets) and qualitative (offering an array of innovative products and services enabled by the deployment of new networks) and the availability of new devices. The paper reveals how each technological wave ushered in a series of innovation and new services, boosted the foundation and the growth of pioneering companies.

Research limitations/implications
Taking into account the lack of official data, the industry data used should be treated as just signals of potential trends, but sufficient to give an overview of the evolution of the global internet markets. Furthermore, detailed studies should complement this descriptive approach. The approach does have obvious methodological and theoretical limits, not providing a robust methodological framework just offering a reconstruction of the trends as documented by the trade publications. However, it concludes highlighting some of the tensions and contradictions.

Practical implications
The paper closes with a summary of the main transformations and considers some future developments. The paper draws some lessons from some failures and from the strategies of firms.

Social implications
The paper hints at the way users developed “unique” behaviors using social media, taking advantage of the new opportunities to exchange with others. The paper hints at some regulatory issues and challenges.

Originality/value
The paper briefly sums up the very dynamics of the global internet market(s). It attempts to characterize some of the main features of their evolution and of the main segments. If offers a comprehensive overview of available data.
Building social-capital networks and relationship commitment in China and India
Authors: Graça Sandra Simas , Kharé Virginie Pioche 
Published: May 2020

PurposeThis study aims to develop a framework based on drew social capital theory and the literature onguanxito examine and compare a buyer’s willingness to commit to a supplier in the context of informal social-capital networks in the two largest emerging markets of China and India. The two main objectives of the study included an examination of the influence of communication behavior and conflict resolution on the development of social-capital networks and a comparison of the influence of distinct dimensions of social-capital networks on a buyer’s commitment to a supplier.Design/methodology/approachData was collected in China and India from random samples of buyers. The model was tested using structural equation modeling.FindingsFindings revealed that communication and conflict resolution contribute significantly to build trust, increase social benefits and promote mutual collaboration between buyers and suppliers in both China and India. However, social benefits were found to have a greater influence on commitment in India, whereas collaboration was found to have a greater influence on commitment in China.Practical implicationsThe study demonstrates the importance of social capital theory to explain the informal social capital network and commitment development. Results provide practitioners with specific strategies to build social capital in China and India and improve committed relationships with buyers.Originality/valueThis study advances theory development within the context of emerging markets. It is unique as it includes the two most populous and fast-growing emerging markets in one study.
The amazonisation of second hand technical equipment: Topotrade case
Authors: Khoury Aliaa , Menhem Nayla , Youakim Liliane Elias , Salame Yara 
Published: May 2020

Learning outcomes
This case reflects a classic approach to entrepreneurship based on entrepreneurial resources and opportunities. It also provides a vehicle for discussing the key features of a business model. It also addresses key strategic choices such as whether to replicate a business model or not.

Case overview/synopsis
This case study sets out the story of an entrepreneur: Zein Rachidi. It describes his history and the key milestones in his professional development until the creation and development of his own startup “Topotrade” the first online market place for used topography equipment. It also exposes his development plan, his will to scale up his business by replicating the same business model of Topotrade in a new market, that of used biomedical equipment.

Complexity academic level
This case is written mainly with a view to its use in the context of entrepreneurship courses for undergraduate students in management, as well as for entrepreneurs who can compare Zein’s trajectory to their own. This case is designed for students also suitable for courses in basic strategy, strategy and change and disruptive business models.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 3: Entrepreneurship.