bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Path to Relief from the Intertwined Effects of School Bullying and Loneliness: The Power of Social Connectedness and Parental Support
Authors: Liu Huaqiang , Lan Zhensong , Wang Qing , Huang Xuefang , Zhou Jianming 
Published: December 2024

Abstract

Background: School bullying is a widespread phenomenon affecting a significant proportion of adolescents worldwide, yet the relationship between school bullying and loneliness has received little attention. The aim is to understand the relationship between adolescents experiencing school bullying and loneliness, and to explore the role of social connectedness and parental support in this relationship.
Methods: This study used cluster sampling to select 1,277 students from grades 7 to 12 in four middle schools across two cities in Sichuan Province. Data were collected via questionnaires and analysis was carried out using descriptive statistics, chain mediation model tests, and moderation model tests.
Results: The results showed that: (1) Bullying was significantly positively correlated with adolescent loneliness (r = 0.55, P < 0.001); (2) Social connectednessplayed a mediating role between bullying and adolescent loneliness (effect size of 51.57%); (3) After controlling for gender, age, and household registration type, parental support moderated the relationship between bullying and loneliness among adolescents (β = -0.05, p < 0.01). Moreover, as the level of parental support increased, the positive predictive effect of bullying on loneliness weakened significantly, although this moderating effect was not significant among "non-left-behind children."
Conclusion: The study confirmed the relationship between school bullying and loneliness and revealed the internal logical relationship between social connectedness, parental support, loneliness, and school bullying, providing agreat significance for preventing the negative effects of school bullying on left-behind children.
Central Nervous System Disease and Outcome in Pediatric Acute Myeloid Leukemia: Results from NOPHO-DBH AML2012 Trial
Authors: Arad-Cohen Nira , Cheuk Daniel , De Moerloose Barbara , Mavarro Jose , Hasle Henrik , Jahnukainen Kirsi , Juul-Dam Kristian , Kaspers Gertjan , Kovalova Zhanna , Jonsson Olafur , Lausen Birgitte , Munthe-Kaas Monica Cheng , Norén-Nyström Ulrika , Palle Josefine , Pasaulienė Ramunė , Pronk Cornelis , Saks Kadri , Tierens Anne , Zeller Bernward , Abrahamsson Jonas 
Published: December 2024

Abstract

Background: Central nervous system disease (CNS3) in pediatric acute myeloid leukemia (pAML) is reported in 6% to 29% of cases. However, its impact on event-free survival (EFS) and overall survival (OS) remains uncertain. This study evaluates the effect of CNS involvement at diagnosis on relapse and survival in patients treated on the NOPHO-DBH AML2012 protocol.
Methods:
Data from 931 pediatric AML patients in the NOPHO-DBH AML2012 protocol were analyzed, comparing outcomes, relapse rates, and survival between those with and without CNS disease. CNS-directed therapy included intensified intrathecal chemotherapy without irradiation.
Results: Of 922 patients with available CNS status, 10.9% had CNS3 at diagnosis. CNS3 patients were younger (median age 3.5 vs. 8 years,P=0.001) with higher white blood cell counts (56.1x109/L vs 18.7x109/L,P<0.001) and higher frequency of other extramedullary disease (30.4% vs 11.3%,P<0.001) and inv(16)(P<0.001).
EFS5y was 71.5% for CNS-positive patients vs. 62.7% for CNS-negative (p=0.14), and OS5y was 81.4% vs. 79.3% (p=0.54). Patients with CNS disease had a lower cumulative incidence of relapse (15.6% vs 26.5%,P=0.023), and CNS relapse occurred in 0.9% and 0.7% of patients with and without CNS disease.
Conclusion: CNS disease at diagnosis in pAML does not adversely affect survival or treatment response.
Neurodevelopmental Disorder Due to a Frameshift Mutation in the GRIN2A Gene: A Case Report and Literature Review
Authors: Xu Chen , Wang Man-Li , Ling Wei-Hao , Tang Ji-Hong 
Published: December 2024

Abstract

Background: The GRIN2A gene is known to harbor rare mutations that can lead to neurodevelopmental disorders with diverse phenotypic presentations. This report describes a previously unreported case of a rare condition that initially presented with ataxia, followed by speech impairments without seizures, and showed subsequent improvement following immunotherapy.
Case presentation: A 23-month-old male patient initially presented with ataxia. Despite the exclusion of autoimmune encephalitis, a definitive diagnosis remained undetermined. After undergoing immunotherapy, the patient experienced temporary symptom relief. However, he later developed speech impairment, drooling, and developmental regression, without seizures. Electroencephalogram (EEG) findings revealed abnormal patterns during sleep. Whole-genome sequencing identified a frameshift mutation in the GRIN2A gene (c.1717delG, p.Val573Phefs*16), which encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, essential for excitatory neurotransmission in the central nervous system. Following treatment with corticosteroids and immunoglobulin, the patient showed improvements in ataxic gait, cessation of drooling, and a significant reduction in abnormal EEG discharges.
Conclusions: This report broadens the phenotypic spectrum associated with GRIN2A mutations and proposes a promising treatment strategy.
Smart Conservation: Deep Learning-Driven Pathology Detection and Analysis in Historic Masonry Buildings of Suzhou
Authors: Chen Xi , He Jiabao , Wang Shiruo 
Published: December 2024

Abstract

Suzhou's modern masonry buildings hold substantial historical significance, yet they face escalating risks of deterioration due to regional climate fluctuations and anthropogenic influences. Prompt detection of these issues is essential for effective conservation and restoration. This paper addresses this need by integrating UAV technology with deep learning models to enhance the detection of building pathologies, focusing on five categories: material loss (ML), discoloration and deposits (DD), cracks (CR), surface spalling (SS), and biological invasion (BI). The method integrated 3D scanning and oblique photogrammetry to enable automated facade analysis, effectively addressing the limitations of manual inspection. As a case study, the historical site of Soochow Hospital was examined to demonstrate the practical application of quantifying pathology data. 1,200 facade images were collected, including 781 used for pathology detection. The model’s detection accuracies for each pathology type were as follows: biological invasion (75.6%), discoloration and deposits (43.1%), cracks (46.5%), and surface spalling (48.5%), demonstrating the model's capability to meet basic conservation requirements. This approach ultimately provides valuable technical support for the preservation of Suzhou's masonry buildings and offers new insights into the conservation of modern masonry heritage.
Association between menopause, postmenopausal hormone therapy and peptic ulcer disease in Taiwanese population
Authors: Chen Kuan-Chih , Kuo Chia-Yu , Tsai Wan-Ling , Wu Ying-Jhen , Geng Jiun-Hung , Kuo Chao-Hung , Chen Szu-Chia 
Published: December 2024

Abstract

Menopause is associated with various health conditions such as osteoporosis, obesity, cardiovascular and psychological disorders. However, limited information is available on the relationship between perimenopause and hormone replacement therapy with the occurrence of digestive ulcers. Therefore, we conducted this population-based study of over 17,000 participants in the Taiwan Biobank to examine the association between menopause and peptic ulcer disease (PUD). In addition, we also examined associations between the types of menopause and postmenopausal hormone therapy with PUD. Menopausal status, hormone replacement therapy during menopause, and the presence of PUD were determined using self-reported questionnaires. The participants were grouped according to whether or not they had entered menopause. The participants were further categorized based on the cause of menopause: natural or surgical. Binary logistic regression was utilized for correlation analysis. Of the 17,460 individuals enrolled for analysis, 9620 (55%) were classified into the postmenopausal group and 7840 (45%) into the premenopausal group. After adjusting for various factors, the postmenopausal group had a 1.19 times higher risk of developing PUD compared to the premenopausal group (odds ratio [OR]: 1.19, 95% confidence interval [CI]: 1.03 to 1.38, p = 0.022). Moreover, surgical menopause was significantly associated with PUD (OR, 1.38; 95% CI, 1.16 to 1.63; p < 0.001), but natural menopause was not (OR, 1.128; 95% CI, 0.96 to 1.30; p = 0.153). In addition, the women with natural menopause who received postmenopausal hormone therapy had a significantly higher prevalence of PUD than those who did not (OR, 1.37; 95% CI, 1.11 to 1.70; p = 0.004). However, no significant association was found between postmenopausal hormone therapy and PUD among the women with surgical menopause (p = 0.622). Menopause was significantly associated with PUD. Furthermore, surgical menopause (vs. pre-menopause) was associated with a 1.38 times higher risk of PUD, and postmenopausal hormone therapy in women with natural menopause was associated with a 1.37 times higher risk of PUD. Further research is warranted to identify the mechanisms and potential interventions to reduce susceptibility to digestive ulcers in menopausal women.
Charlotte's Crime Landscape: Analyzing the Location of Criminal Activity; A Comprehensive Study of Crime Trends Over Six Years (2017-2023)
Authors: Baltimore Adam 
Published: December 2024

Abstract

This study analyzes crime data from 2017 to 2023 within the City of Charlotte to identify areas with higher crime rates and understand the spatial distribution of crime. Using a variety of analytic tools, including ArcGIS, crime incidents were geolocated and analyzed to reveal patterns. The findings indicate that 45.73% of all crimes and 56.20% of violent crimes occurred within private residences, underscoring the significant role residential areas play in the overall crime rate. Additionally, the uptown area of Charlotte emerged as a notable hotspot for both overall and violent crime, supported by spatial analysis and standard distance measures. Public locations such as streets and commercial areas also showed high crime rates, suggesting targeted strategies for public safety improvements. The study proposes a range of solutions, including enhanced security measures in residential areas, increased law enforcement presence in identified hotspots, and urban environment enhancements to deter crime. These findings offer valuable insights for city officials, law enforcement, and community stakeholders to develop more effective crime prevention strategies.
Highly pathogenic avian influenza virus H5N1 infection in dairy cows confers protective immunity against reinfection
Authors: Zhou Yan , Facciuolo Antonio , Aubrey Lauren , Barron-Castillo Ulises , Berube Nathalie , Norleen Carla , McCreary Shannon , Huang Yanyun , Pessoa Natalia , Jacome Leslie Macas , Mubareka Samira , McGeer Allison , Berhane Yohannes , Gerdts Volker , Kessel Andrew Van , Warner Bryce 
Published: December 2024

Abstract

An unprecedented spillover of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b to dairy cows in March 2024 has affected over 700 US dairy herds in addition to spillback to commercial poultry and transmission to agricultural workers. HPAI H5N1 incursion into cows causes severe mastitis and significant milk production losses. To better understand disease pathogenesis and natural immunity in lactating cows we inoculated the hindquarters of the udder with HPAI H5N1 genotype B3.13 via the teat canal to mimic intra-mammary route of infection. Inoculated cows displayed clinical responses consistent with that observed in affected US dairy herds including generalized decrease in milk yield and localized viral shedding and mastitis in the hindquarters. Following resolution of infection at 31 days post-inoculation, H5N1 virus was inoculated into the unaffected forequarters of the same cows. The secondary inoculation did not result in the clinical manifestations seen upon initial viral challenge. This demonstrated that primary infection of the hindquarters induced natural immunity that conferred complete protection from both mastitis and virus replication and shedding in the forequarters of the udder. This study provides the first experimental report on reinfection demonstrating intra-mammary inoculation can generate H5N1 immunity to completely protect the cow mammary gland.
Alborihi Technique: A Bedside Approach for Managing Brain Abscess and Subdural Hematoma.
Authors: Alborihi Soliman Noman Abdullah 
Published: December 2024

Abstract

pediatric patients. The Alborihi technique is a novel, bedside, percutaneous approach for managing subdural hematomas and brain abscesses. In two cases—one involving a subacute subdural hematoma and the other a brain abscess—the Alborihi technique was successfully implemented using a percutaneous trans-pterional approach, demonstrating the safety of this technique in the pediatric population.
Conclusion
The Alborihi technique is a novel, bedside, percutaneous method for managing liquid masses in the intracranial space. It can be performed quickly, efficiently, and with minimal equipment support, particularly for patients with interosseous patent or bone defects.
Composition analysis of pottery from the Jiangjiashan and Bianjiashan cemeteries in Liangzhu Ancient City, China: A comparative perspective
Authors: Yao Shuai , He Limin , Chen Minghui , Zhao Ye 
Published: December 2024

Abstract

In Liangzhu Ancient City, burials of different levels followed a strict system in terms of the types and quantities of jade, while in sharp contrast, both elites and commoners used only basic pottery assemblages in their burials. In order to clarify whether there is a difference in the production of burial pottery used by Liangzhu elites and commoners, to explore the role of pottery in the process of Liangzhu's social complexity, and to compare it with the relevant study of the Qujialing culture, this paper selects 201 pieces of pottery samples from the elite cemeteries of Jiangjiashan and the commoners' cemeteries of Bianjiashan in Liangzhu Ancient City, and analyzes them for their chemical compositions by using pXRF. The results show that there is a difference in the origin of the burial pottery used by the Jiangjiashan elites and the Bianjiashan commoners. The burial pottery used by the Jiangjiashan elites was most likely the product of processing for specific funerary events, and the corresponding production activities were controlled by the elites; whereas the burial pottery used by the Bianjiashan commoners came from a high level of specialized production, and there was a differentiation in the production of the vast majority of the coarse paste pottery and fine paste pottery, which should be spontaneous and independent, and the elite did not intervene. Therefore, in addition to jade, the burial pottery used by the Liangzhu elites also served as an expression of their status, i.e., controlling the production of special pottery was one of the means of constructing their identities. This phenomenon is quite different from that of the Qujialing society because of the significant differences in their social structure and in the way the elites governed.
AQUARIUM_HB: a bioinformatics pipeline for human blood circular RNA analysis
Authors: Yuan Shaoxun , Bai Xue , Li Linwei , Gu Wanjun 
Published: December 2024

Abstract

Accurately identifying and quantifying human blood circular RNAs (circRNAs) from RNA-seq data is a critical bioinformatics challenge in biomarker discovery for human diseases. In this study, we present AQUARIUM-HB, a comprehensive bioinformatics pipeline for identifying, quantifying, annotating, and analyzing circRNAs from human blood transcriptomes. AQUARIUM-HB includes three functional modules. First, it identifies and annotates circRNAs from rRNA-depleted RNA-seq datasets of human blood samples. Second, it performs an in-depth expression analysis of blood circRNAs. Third, it constructs a reference set of full-length blood circRNAs. We demonstrate the application of AQUARIUM-HB using a human blood RNA-seq dataset from COVID-19 patients, showcasing its potential for improving the accuracy and depth of circRNA biomarker discovery.
The Role of Twitter Sentiment in the Analysis of Housing Prices in Turkey
Authors: Duzcu Hidayet , Yanar Rüstem 
Published: December 2024

Abstract

The housing market is an important reflection of economic stability and the financial situation of individuals. Therefore, understanding the factors associated with house prices is very important for individuals and policymakers. While traditional economic indicators and data sources are widely used in analyzing the housing market, new data sources such as social media platforms have increasing potential. This study aims to analyze whether there is a relationship between data shared on X (Twitter), one of the social media platforms, and house prices. As a platform where users express their thoughts and feelings, X can reflect perceptions and trends about the housing market. Within the scope of the study, sentiment analysis was conducted on a total of 57,646 tweets in Turkish, and the results of the analysis were associated with house prices. The findings show that 65.21% of the tweets contain neutral, 27.07% negative, and 7.72% positive sentiment. This suggests that social media users have a largely neutral attitude towards the housing market. While neutral sentiments are usually excluded from the literature, this study offers an important innovation to the literature by addressing neutral sentiments comprehensively. The results show that sentiment analyses derived from social media data provide a valuable contribution to understanding housing market dynamics and can offer an alternative perspective to traditional economic methods. In this respect, the study aims to shed light on the understanding of housing market dynamics through a new approach using social media data in addition to traditional economic analysis.
Squid (Loligo Sp.) Ink Powder as Immunostimulant Candidate for Vannamei Shrimp (Litopenaeus Vannamei) Against Infectious Myonecrosis Virus (IMNV)
Authors: Fadjar Mohammad , Kemp Paul , Herlina Cucun , Affandi Rangga Idris , Aisyah Diana , Ramadhani Ayu Winna , Anjaini Jefri 
Published: December 2024

Abstract

Introduction: Infectious Myonecrosis Virus (IMNV) attack vannamei shrimp (Litopenaeus vannamei) in the muscles and hepatopancreas that threatens shrimp culture. Strategies to avoid mortality can be carried out through squid (Loligo sp.) ink powder to improve the body's defense system. The study aimed at investigating the effects of squid (Loligo sp.) ink powder to non-specific immune response of vannamei shrimp (L. vannamei) against IMNV.
Results: Completely Randomized Design (CRD) was utilized consisting of 3 treatments and 2 controls i.e. a dose of 400, 500, and 600 mg squid ink powder / kg feed and infected with IMNV; also positive control (K +) i.e. shrimp infected with IMNV without giving squid ink powder, and negative control (K-) i.e. healthy shrimp without treatment and IMNV infection, each with 3 replications. The result of increasing non-specific immune activity was marked by increasing in the highest Total Hemocyte Count (THC), Differential Hemocyte Count (DHC), Respiratory Burst (RB), Super Oxyde Dismutase (SOD), Phenoloxidase (PO), reducing of Ribonucleotide Reductase (RR) and phagocytic activity with the highest results at the 3rd week (7 days after infection).
Conclusion: In this study, we investigated that the squid (Loligo sp.) ink powder has the potential and capability to enhance the immune system in shrimp. The result showed, 500 mg squid ink powder/kg feed was the best dose because increase the activity of non-specific immune responses against IMNV.
Operation of solid municipal waste landfills in northern climates
Authors: Zabelina A. V. 
Published: December 2024

The author considers specific features of operation of solid municipal waste landfills at the post-operation stage in northern climate conditions. It is emphasized that safe operation of landfills requires efficient management of landfill gas and leachate formation. Increased precipitation leads to increased waste moisture content and, as a consequence, to methane generation during different seasons. The author presents the results of measuring methane concentrations and calculating leachate volumes at a landfill located in the north-west of Russia. The conclusion is made about the need to control and manage leachate formation, as well as to take measures for its treatment to prevent environmental and sanitary-hygienic problems associated with evaporation and accumulation of leachate.
Is the existence of a relict primate in the Far North possible?
Authors: Sapunov V. В. 
Published: December 2024

The author sets out to generalize the existing information about a humanoid creature in the Russian Far North by analyzing the reports of local residents, travelers, and researchers, as well as by studying local legends and folklore tales. The data is evaluated from the perspectives of folklore studies and the theory of testimonial evidence. The reliability of this evidence, which resonates well with the traces of prehistoric human activity found in Yakutia, cannot be fully ruled out. Given the low anthropogenic load and the scarcity of knowledge about these places, the possibility of the existence of animals, which are unknown to science, cannot be refuted. The author evaluates the theoretical possibility of the existence of a highly developed primate in northern and other areas of the planet, which cannot be accessed by conventional methods of zoology.
Dynamic characteristics analysis and optimization of oil tank
Authors: Han Xin 
Published: December 2024

The response of oil tanks under dynamic loads is the key to ensuring safety, and the analysis of stiffness and strength is very necessary. Modal analysis was carried out on the oil tank to obtain the natural frequencies and vibration modes. Under specific excitation frequencies, the stress responses of the dangerous points of the front head, the rear head, the cylinder, and the transverse wave plate were calculated respectively. Three filling rates of 30 %, 50 % and 70 % were respectively selected for the structural response study, and the structural deformation and stress responses of the storage tank structure under the impact of different volumes of liquid were obtained. According to the dynamic response analysis, the structure of the front head and transverse wave plate were strengthened. It can be known from the comparison of mechanical properties that the optimized structure can significantly improve the stiffness and strength, and effectively ensure the safety of the oil tank.