bluuebunny/crossref_metadata_2025_split huggingface dataset:
g‐C3N4/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine
Authors: Wang Minmin , Zhang Mengke , Zhu Jinli , Wang Jin , Hu Lanping , Sun Tongming , Wang Miao , Tang Yanfeng 
Published: February 2020

AbstractA highly sensitive and selective electrochemical sensor based on g‐C3N4/Co nanohybrids was developed for simultaneous detection of uric acid and dopamine. The g‐C3N4/Co nanohybrid modified electrode shows excellent catalytic response towards the oxidation of uric acid and dopamine, with an anodic peak during differential pulse voltammetry at around 300 mV and 150 mV (Ag/AgCl) taken at pH 7.4, respectively. Good linear relationships between peak current intensities and concentrations were obtained in the range of 1 to 1000 μM and 1 to 400 μM for uric acid and dopamine, and the limit of detection (S/N=3) was 0.4 μM and 0.5 μM, respectively. Further analysis revealed the key role of synergistic effect of Co NPs and g‐C3N4 in boosting the oxidation of uric acid and dopamine. The newly developed sensor was successfully applied to human serum samples for a fast‐electrochemical determination of uric acid. These results demonstrate that the g‐C3N4/Co nanohybrid is a promising candidate of advanced electrode material in electrochemical sensing and other electrocatalytic applications.
Inside/Outside: Post‐Synthetic Modification of the Zr‐Benzophenonedicarboxylate Metal–Organic Framework
Authors: Mohmeyer Alexander , Schäfer Malte , Schaate Andreas , Locmelis Sonja , Schneider Andreas M. , Behrens Peter 
Published: February 2020

AbstractThe Zr‐based metal–organic framework, Zr‐bzpdc‐MOF, contains the photoreactive linker molecule benzophenone‐4,4′‐dicarboxylate (bzpdc) which imparts the possibility for photochemical post‐synthetic modification. Upon irradiation with UV light, the keto group of the benzophenone moiety will react with nearly every C−H bond‐containing molecule. Within this paper, we further explore the photochemical reactivity of the Zr‐bzpdc‐MOF, especially with regard to which restrictions govern internal versus external reactions. We show that apart from reactions with C−H bond‐containing molecules, the MOF reacts also with water. By studying the reactivity versus linear alcohols we find a clear delineation in that shorter alcohol molecules (up to butanol as a borderline case) react with photoexcited keto groups throughout the whole crystals whereas longer ones react only with surface‐standing keto groups. In addition, we show that with the alkanes n‐butane to n‐octane, the reaction is restricted to the outer surface. We hypothesize that the reactivity of the Zr‐bzpdc‐MOF versus different reagents depends on the accessibility of the pore system which in turn depends mainly on the size of the reagents and on their polarity. The possibility to direct the post‐synthetic modification of the Zr‐bzpdc‐MOF (selective modification of the whole pore system versus surface modification) gives additional degrees of freedom in the design of this metal–organic framework for shaping and for applications.
A Polyoxometalate‐Based Binder‐Free Capacitive Deionization Electrode for Highly Efficient Sea Water Desalination
Authors: Liu Hang , Zhang Juan , Xu Xinxin , Wang Qiang 
Published: February 2020

AbstractCapacitive deionization is a promising technique in sea water desalination. Compared with common electrodes, mixed capacitive‐deionization electrodes exhibit better performance in sea water desalination because they integrate pseudocapacitance and electric double‐layer capacitance in one system. Herein, a 3D binder‐free mixed capacitive‐deionization electrode was fabricated by direct electrodeposition of SiW12O404− and polyaniline on a 3D exfoliated graphite carrier. In this electrode, SiW12O404−/polyaniline composite particles with a size of about 100–120 nm are dispersed homogenously on the 3D exfoliated graphite carrier. Its specific capacitance reaches 352 F g−1 at 1 A g−1. With increasing current from 1 to 20 A g−1, the specific capacitance only decays by 32 %. When employed in sea water desalination, the performance of this mixed capacitive‐deionization electrode is also excellent. At 1.2 V, the salt adsorption capacity of this mixed electrode reaches 23.1 mg g−1 with a salt adsorption rate of 1.38 mg g−1 min−1 in 500 mg L−1 NaCl. The performance of this electrode is well retained after 30 cycles. The excellent sea water desalination performance originates from the synergistic effect between SiW12O404− and polyaniline. This work has developed polyoxometalate as a new material for capacitive‐deionization electrodes.
Carbon Nitride as a Ligand: Selective Hydrogenation of Terminal Alkenes Using [(η5‐C5Me5)IrCl(g‐C3N4‐κ2N,N’)]Cl
Authors: Coulson Ben , Lari Leonardo , Isaacs Mark , Raines Daniel J. , Douthwaite Richard E. , Duhme‐Klair Anne‐K. 
Published: February 2020

AbstractAnchoring a homogeneous catalyst onto a heterogeneous support facilitates separation of the product from the catalyst, and catalyst‐substrate interactions can also modify reactivity. Herein we describe the synthesis of composite materials comprising carbon nitride (g‐C3N4) as the heterogeneous support and the well‐established homogeneous catalyst moiety [Cp*IrCl]+ (where Cp*=η5‐C5Me5), commonly used for catalytic hydrogenation. Coordination of [Cp*IrCl]+ to g‐C3N4 occurs directly at exposed edge sites with a κ2N,N’ binding motif, leading to a primary inner coordination sphere analogous to known homogeneous complexes of the general class [Cp*IrCl(NN‐κ2N,N’)]+ (where N,N’=a bidentate nitrogen ligand). Hydrogenation of unsaturated substrates using the composite catalyst is selective for terminal alkenes, which is attributed to the restricted steric environment of the outer coordination sphere at the edge‐sites of g‐C3N4.
Single‐Chain Magnet Based on Cobalt(II) Thiocyanate as XXZ Spin Chain
Authors: Rams Michał , Jochim Aleksej , Böhme Michael , Lohmiller Thomas , Ceglarska Magdalena , Rams Marek M. , Schnegg Alexander , Plass Winfried , Näther Christian 
Published: February 2020

AbstractInvited for the cover of this issue is the group of Michał Rams at Jagiellonian University (Kraków, Poland) and colleagues at Christian‐Albrechts‐Universität zu Kiel, Friedrich‐Schiller‐Universität Jena, and Helmholtz‐Zentrum Berlin. The image represents a 1D coordination polymer with Co(II) spins that are flipped by photons during an EPR experiment. Read the full text of the article at 10.1002/chem.201903924.
Lower eGFR is associated with increased probability of liver fibrosis in Chinese diabetic patients
Authors: Wang Yuying , Yu Yuetian , Wan Heng , Chen Yi , Xia Fangzhen , Zhang Wen , Zhang Kun , Gu Xinjie , Zhang Yihao , Lin Zhiqi , Yu Yuefeng , Wang Ningjian , Lu Yingli 
Published: February 2020

AbstractBackgroundKidney dysfunction is linked to nonalcoholic fatty liver disease (NAFLD) progression including fibrosis, steatosis, or inflammation. We aimed to explore whether lower levels of estimated glomerular filtration rate (eGFR) was associated with increased probability of liver fibrosis.MethodsTwo thousand six hundred eighty‐nine subjects enrolled from Shanghai, China, were included in this study. NAFLD fibrosis score (NFS) was used to risk stratify NAFLD patients for fibrosis. eGFR was used to assess kidney function. The association of eGFR level with elevated NFS, and thus high risk of fibrosis, was analysed by linear regression and multinomial logistic regression. The predictive power of eGFR was evaluated via receiver operating characteristic (ROC) curve.ResultsA negative association was found between eGFR and NFS (B = −0.21, 95% CI, −0.37 to −0.04, P = .016). As eGFR quartiles decreased, the prevalence of probable fibrosis increased after adjusting for age, sex, current smoking, waist circumference, duration of diabetes, HbA1c, hypertension, dyslipidaemia, and homeostasis model assessment index of insulin resistance (HOMA‐IR) (Q4: reference; Q3: 1.49, 95% CI, 0.82‐2.71; Q2: 1.88, 95% CI, 0.97‐3.67; Q1: 2.70, 95% CI, 1.36‐5.37, Pfor trend = .002, 1SD increment: 0.73, 95% CI, 0.58‐0.92). The eGFR level can be an effective indicator in differentiating patients with probable presence of fibrosis from those without (AUROC: 0.71, cut‐off point: 92.78 mL/min/1.73 m2, P < .001).ConclusionsLower levels of eGFR were associated with higher NFS and thus greater risk of presence of fibrosis in patients with NAFLD and T2DM. Individuals with NAFLD and diabetes should carefully monitor eGFR and receive regular urinalysis, especially when advanced fibrosis is suspected.
Scenario planning as strategic activity: A practice‐orientated approach
Authors: Bowman Gary , MacKay R. Bradley 
Published: February 2020

AbstractScenario planning has become detached from its roots in strategic management. The dominance of strategy process research and the search for links to performance and impact have pushed researchers away from strategy perspectives. While the cognitive stream of research has provided many insights, a practice approach is presented as an alternative theoretical perspective that reestablishes the role of strategy in a scenario planning process. Within a strategy‐as‐practice perspective, three areas of significance to practice‐orientated scenario planning research emerge: situated practice, macro influences, and micro activities. Scholarly attention to these areas can enhance current theoretical and practical understanding of scenario planning.
RETRACTED: Consequences of hydrogenated vegetable fat substitution with Ajwa seed oil on physicochemical and nutritional aspects of functional cookies
Authors: Raza Muhammad Qasim , Arshad Muhammad Umair , Arshad Muhammad Sajid , Anjum Faqir Muhammad , Imran Ali , Ahmed Aftab , Munir Haroon 
Published: February 2020

AbstractThe core objectives of the current study were to explore and compare the proximate and nutritive composition of both types of cookies prepared either with Ajwa seed oil (ASO) or hydrogenated vegetable fat (HVF) and comparative analysis of the antioxidantal potential of both cookies and to reconnoiter the storage effects on the quality parameters of the cookies over a period of 60 days. Outcomes revealed that the cookies prepared with the ASO were superior (p < .05) in fat% and energy as compared to the cookies with HVF. Due to the presence of functional moieties, ASO cookies were found with better palatability, increased shelf life with enhanced physical properties and better functionality. Therefore, the findings of the current study revealed that ASO could be used as an alternative fat source for the preparation of novel functional cookies instead of conventional vegetable fats.
Vasomodulators and Liver Transplantation for Portopulmonary Hypertension: Evidence From a Systematic Review and Meta‐Analysis
Authors: Deroo Rebecca , Trépo Eric , Holvoet Tom , De Pauw Michel , Geerts Anja , Verhelst Xavier , Colle Isabelle , Van Vlierberghe Hans , Fallon Michael B. , Raevens Sarah 
Published: February 2020

Background and Aims
Untreated portopulmonary hypertension (PoPH) carries a poor prognosis. Previous reports have described vasomodulator (VM) therapy and liver transplantation (LT) as treatment options. We aimed to provide summary estimates on the endpoints of pulmonary hemodynamics and survival in patients with PoPH, treated with different modalities.

Approach and Results
We performed a systematic review with meta‐analysis of mainly observational and case‐control studies describing no treatment, VM, LT, or VM + LT in patients with PoPH. Twenty‐six studies (1,019 patients) were included. Both VM and VM + LT improve pulmonary hemodynamics. A substantial proportion of patients treated with VM become eligible for LT (44%; 95% confidence interval [CI], 31‐58). Pooled estimates for 1‐, and 3‐year postdiagnosis survival in patients treated with VM were 86% (95% CI, 81‐90) and 69% (95% CI, 50‐84) versus 82% (95% CI, 52‐95) and 67% (95% CI, 53‐78) in patients treated with VM + LT. Of note, studies reporting on the effect of VM mainly included Child‐Pugh A/B patients, whereas studies reporting on VM + LT mainly included Child‐Pugh B/C. Seven studies (238 patients) included both patients who received VM only and patients who received VM + LT. Risk of death in VM‐only–treated patients was significantly higher than in patients who could be transplanted as well (odds ratio, 3.5; 95% CI, 1.4‐8.8); however, importantly, patients who proceeded to transplant had been selected very strictly. In 50% of patients, VM can be discontinued post‐LT (95% CI, 38‐62).

Conclusions
VM and VM + LT both improve pulmonary hemodynamics and prognosis in PoPH. In a strictly selected subpopulation of cases where LT is indicated based on severe liver disease and where LT is considered safe and feasible, treatment with VM + LT confers a better prognosis. Considering successful VM, 44% can proceed to LT, with half being able to postoperatively stop medication.
The Couette flow of a conducting Jeffrey fluid when the walls are lined with deformable porous material
Authors: Sunil Babu G. , Sreenadh S. , Gopi Krishna G. , Mishra Satyaranjan 
Published: February 2020

AbstractThe paper deals with the flow, past a deformable porous channel bounded by finite deformable porous layer with moving rigid parallel plates. Transverse magnetic field is also applied and incorporated in the momentum equation. The coupled nonlinear equations are transformed to ordinary differential equations (ODEs) with suitable choice of similarity transformation. Further, these sets of nonlinear ODEs are solved analytically and are used to get results for the flow phenomena. The effects of the porous layer thickness and the drag on the flow phenomena are discussed graphically. It is observed that rigid velocity decreases with increasing in the drag, whereas the decrease in the deformable is noted. It is clear to see that the retards in solid displacement are shown with enhancing viscosity parameter η.
Classification of motor imagery electroencephalography signals using continuous small convolutional neural network
Authors: Rong Yuying , Wu Xiaojun , Zhang Yumei 
Published: February 2020

AbstractAs an important part of brain‐computer interface (BCI), the electroencephalography (EEG) technology of motor imagery (MI) has been gradually recognized for its great theoretical value and practical application. In this study, in view of the different MI tasks corresponding to active region of the EEG signals, we adopt a two‐dimensional form including time, frequency, and electrode location information, then we design a classification method containing continuous small convolutional neural network (CSCNN). This method is mainly used for feature extraction through continuous small convolutional kernels and one rectangle convolutional kernel, and the softmax classifier for classification. In the experiment, classification accuracy and kappa value are used as evaluation criteria to verify the effectiveness of the method proposed in this study. For classification accuracy, BCI competition IV data set 2b is used to compare with the other five classification methods (CNN, CNN‐SAE, stacked autoencoder [SAE], support vector machine [SVM], and one‐dimensional convolution combined with gated recurrent unit [1DCGRU]). The results demonstrate that the overall accuracy of CSCNN is higher than other methods, and CSCNN obtains an average accuracy of 82.8%. For kappa value, BCI competition IV data set 2b is used to compare with the other three methods (filter bank common spatial pattern [FBCSP], Twin SVM, and CNN‐SAE). The performance of CSCNN is better with an average value of 0.663. Overall, the results show that CSCNN maintains a small number of parameters and improves the classification accuracy.
Evaluation of 1‐mm‐diameter endothelialized dense collagen tubes in vascular microsurgery
Authors: Li Xuanyue , Xu Jing , Bartolák‐Suki Erzsébet , Jiang John , Tien Joe 
Published: February 2020

AbstractAlthough much progress has been made in engineering vascular grafts for large‐ and small‐diameter arterial repair or bypass, the extension of these results to the microsurgical size scale has been challenging. Here, we evaluated the use of dense collagen tubes (outer diameter 1 mm, inner diameter 0.5 mm) for vascular microsurgery as interpositional grafts to the femoral artery of Lewis rats. These tubes were formed by dehydrating tubular collagen gels around a mandrel, crosslinking them with genipin, seeding with syngeneic endothelial cells, and culturing before implantation by suture anastomosis. The retention of a confluent endothelial lining inside the tubes after mock surgical handling depended strongly on the crosslinker concentration and culture time. Optimized preparation conditions enabled retention of endothelium after mock surgical handling in ~80% of tubes and maintenance of patency 7 days after implantation in ~40% of grafts. Histological analysis showed the development of granulation tissue and the presence of CD31‐positive structures on the inner and outer surfaces of implants. This study provides a proof‐of‐principle demonstration that endothelialized dense collagen tubes can remain patent for up to 7 days after vascular microsurgery, and points to the importance of mild scaffold crosslinking for maintaining firm endothelial adhesion.
Selective metal ion transport through polymer inclusion membrane containing surfactin as carrier reagents
Authors: Sun Chang , Zhou Chenggang , Zhang Dan , Shen Shusu 
Published: February 2020

AbstractMetal ion selective polymer inclusion membrane (PIM) was prepared by using cellulose triacetate as matrix, surfactin (SF) as ion carrier, and 2‐nitrophenyl n‐octyl ether as plasticizer. The structure and morphology of the prepared PIM were characterized by means of thermogravimetric analysis, scanning electron microscopy, and Fourier transform infrared spectroscopy. The effects of plasticizer and the amount of SF to ionic membrane flux were investigated, and the optimized component was obtained thereof. The selectivity of the membrane toward metal cation was studied and the order of Ni(II) > Ca(II) > Co(II) > Pb(II) > Cu(II) > Mg(II) was followed. In addition, the durability of the PIM was studied by successive reuse of the membrane, and the ionic flux slightly decreased after five cycles of reuse, indicating the excellent durability of the PIM.
PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy‐induced osteoporosis mouse model
Authors: Zhang Ying , Cao Xiangyang , Li Peifeng , Fan Yanan , Zhang Leilei , Li Wuyin , Liu Youwen 
Published: February 2020

AbstractThere is now increasing evidence which suggests a key role for osteoblast apoptosis in the pathogenesis of postmenopausal osteoporosis. Here, we evaluated the role and mechanism of proteasome 26S subunit, ATPase (PSMC) 6, a protein that is highly expressed in bone. Gene expression pattern had been extracted based on database of Gene Expression Omnibus (GEO). GEO2R was employed for analyses, while the DAVID database was adopted to further analyze the gene ontology (GO) as well as Kyoto Encyclopedia of Genomes pathway (KEGG) enrichment. Then, the Search Tool Retrieval of Interacting Genes (STRING) was utilized to carry out interaction regulatory network for the top 200 differentially expressed genes (DEGs). A key gene, called PSMC6, was identified by Cytoscape 3.6.0. The OVX osteoporosis model was established in female C57BL/6 mice by full bilateral ovariectomy. According to our findings, PSMC6 gene knockout would elevate bone mineral density (BMD) and the phosphorylation level of PI3K protein and increased the protein level of cleaved caspase‐3/‐9 in OVX osteoporosis mice. Further, MTT, bromodeoxyuridine, and flow cytometry assays revealed that PSMC6 inhibition promoted the progression of cell cycle and cell proliferation, whereas, PSMC6 overexpression promoted the apoptosis and inhibited cell cycle progression and cell proliferation in vitro. Besides, we found that PI3K activation significantly decreased PSMC6‐induced osteoblast apoptosis and promoted cell proliferation through regulating the protein levels of p53, cyclinD1, and cleaved caspase‐3/9. In conclusion, PSMC6 aggravated the degree of OVX‐induced osteoporosis by inhibiting the PI3K/AKT signal transduction pathway, thereby promoting the apoptosis of osteoblasts.
Pak2 inhibition promotes resveratrol‐mediated glioblastoma A172 cell apoptosis via modulating the AMPK‐YAP signaling pathway
Authors: Xing Jin , Wang Zhihan , Xu Hao , Liu Chaobo , Wei Zilong , Zhao Liang , Ren Li 
Published: February 2020

AbstractAs a polyphenolic compound, resveratrol (Res) is widely present in a variety of plants. Previous studies have shown that Res can inhibit various tumors. However, its role in c remains largely unexplored. In the present study, we first demonstrated that Res inhibited cell viability and induced apoptosis of glioblastoma A172 cell. Further experiments showed that Res induced mitochondrial dysfunction and activated the activity of caspase‐9. Functional studies have found that Res treatment is associated with an increase in the expression of Pak2. Interestingly, inhibition of Pak2 could further augment the proapoptotic effect of Res. Mechanistically, Pak2 inhibition induced reactive oxygen species overproduction, mitochondria‐JNK pathway activation, and AMPK‐YAP axis suppression. However, overexpression of YAP could abolish the anticancer effects of Res and Pak2 inhibition, suggesting a necessary role played by the AMPK‐YAP pathway in regulating cancer‐suppressive actions of Res and Pak2 inhibition. Altogether, our results indicated that Res in combination with Pak2 inhibition could further enhance the anticancer property of Res and this effect is mediated via the AMPK‐YAP pathway.
Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma
Authors: Khatami Fatemeh , Larijani Bagher , Heshmat Ramin , Nasiri Shirzad , Haddadi‐Aghdam Mohammad , Teimoori‐Toolabi Ladan , Tavangar Seyed M. 
Published: February 2020

AbstractCirculating cell‐free DNA (cfDNA) has been considered as a diagnostic source to track genetic and epigenetic alterations in cancer. We aimed to study mutation in addition to the methylation status in the promoter regions of RASSF1 and SLC5A8 genes in tissues and circulating free DNA samples of patients affected with papillary thyroid carcinoma (PTC) and thyroid nodules as controls. BRAFV600E mutation was studied by ARMS‐scorpion real‐time polymerase chain reaction method in 57 PTC and 45 thyroid nodule cases. Methylation status of RASSF1 and SLC5A8 promoter regions was analyzed by methylation‐specific high‐resolution melting curve analysis. BRAFV600E mutation was found in 39 (68.4%) out of 57 PTC tissue samples, while in 33 (49.1%) cases of cfDNA, this mutation was detected. The frequency of BRAFV600E mutation in cfDNA was significantly different between metastatic and nonmetastatic PTC cases (22 of 33 PTC cases vs. 5 of 34 thyroid nodule samples). Methylation levels of three promoter regions of SLC5A8 and proximal promoter region of RASSF1 was significantly different between PTC and thyroid nodule cases in both cfDNA and tissue DNA. In addition, the methylation status of these two genes in tissue DNA was reflected in methylation status observed in cfDNA. This study confirmed that BRAFV600E mutation is better for discrimination between papillary thyroid carcinoma and thyroid nodules. On the other hand, hypermethylation in the more proximal promoter regions to RASSF1 and SLC5A8 genes showed higher sensitivity and more acceptable specificity for this discrimination.