bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study of blast loading behind a building corner
Authors: Gajewski T. , Sielicki P. W. 
Published: January 2020

AbstractThe paper presents unique blast experiments in reference to scientific literature and official standards. Experimental scenarios reflect a hypothetical realistic combat situation of a human being covered from a blast wave behind a rigid building corner. In the scenario assumed, the overpressure loads affect the lungs while the person is standing or the eardrums while the person is kneeling at the aiming position. The paper presents 27 free-field experiments measuring the overpressure loads. All the measurements were taken behind the right angle of the rigid wall. Two masses of TNT were considered: 200 g and 400 g. In the selected cases, a low test-to-test variability of the measured data was observed. Detailed plots of overpressure versus time are presented for various distances behind the building corner and TNT charge masses. Peak overpressure versus positive impulse plots are also demonstrated. Furthermore, the safety thresholds regarding different locations behind the building corner are defined for the considered explosive masses.
Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract
Authors: Szymaszkiewicz Agata , Włodarczyk Jakub , Wasilewski Andrzej , Di Marzo Vincenzo , Storr Martin , Fichna Jakub , Zielińska Marta 
Published: January 2020

AbstractTRPV1 are involved in the control of the gastrointestinal (GI) functions and pain sensation. Their activation induces pain but it is followed by desensitization, which in turn causes analgesia. The studies from the last two decades indicate that TRPV1 are involved in visceral hypersensitivity in the GI tract and pathogenesis of irritable bowel syndrome (IBS). Therefore, the aim of this study is to assess the action of fast desensitizing agonist of TRPV1, palvanil (N-palmitoyl-vanillamine), in the murine GI tract and on nociception to evaluate its potential application in the therapy of IBS. The effect of palvanil on smooth muscle contractility was evaluated using organ baths. The impact of palvanil on intestinal secretion was assessed in Ussing chambers. In vivo, the action of palvanil (0.1–1 mg/kg) was assessed in whole GI transit, fecal pellet output, and colonic bead expulsion tests. The antinociceptive potency of palvanil was tested in the mustard oil-induced pain test. Palvanil inhibited colonic contractions (evoked by electrical field stimulation, EFS) and decreased the ion transport in the colon stimulated with forskolin. It did not affect secretion in experiments with veratridine. In vivo, palvanil prolonged whole GI transit at all doses tested. At the lower dose tested, it accelerated colonic motility during first 60 min following injection. By contrast, at the dose of 1 mg/kg, colonic motility was inhibited. Palvanil induced antinociceptive action at all tested doses in mustard oil-induced pain test. TRPV1 fast-desensitizing compounds, i.e., palvanil, may be promising agents in the therapy of IBS since it modulates intestinal motility and reduces visceral pain.
Surgical defect reconstructions in knee, lower leg, and foot with flaps: a retrospective analysis
Authors: Stepniewski Adam , Saul Dominik , Synn Helen , Felmerer Gunther 
Published: January 2020

Abstract
Background
The first description of local fascio-cutaneous flaps used for the coverage of soft tissue defects of the limbs originates from the 1980s. Over the years, this technique has advanced, and in the meantime, a sub-group of flaps named perforator-based propeller flaps has gained increased attention. In our study, we aimed to demonstrate our experience of operating surgeries with perforator-based propeller flaps and to compare this technique with other flap techniques, which are to reconstruct tissue defects of the knee, lower leg, and foot.

Methods
A systematic retrospective search for flap procedures for defect reconstructions in the knee, lower leg, and foot from our database was performed. All data between January 2010 and August 2018 were considered. We identified 56 procedures performed on 14 female and 42 male patients with the mean age of 54.13 years. Reconstruction procedures consisted of 34 free flaps, 14 perforator-based propeller flaps, and eight other perforator-based flaps. Compared to free flaps, the perforator-based propeller flaps had shorter surgery duration by 46.6% (p < 0.0001) and the complication rate in the cases of perforator-based propeller flaps was reduced by 31.14% (p = 0.0315). Furthermore, the operations carried out with perforator-based propeller flaps resulted in a significantly lower rate of revisions by 36.03% (p = 0.0204), compared to those with free flaps. The majority of the donor sites of free flaps were self-closing with the direct suture (p = 0.004).

Conclusions
Based on our findings, we can propose the applicability of perforator-based flaps in treating defects of the knee, lower leg, and foot. With a correct indication, perforator-based propeller flap represents a promising alternative to free flaps, with its significantly shorter surgery duration, lower complications rate, and lower revision rate. However, both techniques of the free flap transfer and the transfer of local pedicle-based flap possess their advantages and disadvantages. Therefore, it is hard to define which microsurgical technique is exclusive in treating lower leg defects.
Level of evidence: Level IV, therapeutic study.
A survey of TIR domain sequence and structure divergence
Authors: Toshchakov Vladimir Y. , Neuwald Andrew F. 
Published: January 2020

AbstractToll-interleukin-1R resistance (TIR) domains are ubiquitously present in all forms of cellular life. They are most commonly found in signaling proteins, as units responsible for signal-dependent formation of protein complexes that enable amplification and spatial propagation of the signal. A less common function of TIR domains is their ability to catalyze nicotinamide adenine dinucleotide degradation. This survey analyzes 26,414 TIR domains, automatically classified based on group-specific sequence patterns presumably determining biological function, using a statistical approach termed Bayesian partitioning with pattern selection (BPPS). We examine these groups and patterns in the light of available structures and biochemical analyses. Proteins within each of thirteen eukaryotic groups (10 metazoans and 3 plants) typically appear to perform similar functions, whereas proteins within each prokaryotic group typically exhibit diverse domain architectures, suggesting divergent functions. Groups are often uniquely characterized by structural fold variations associated with group-specific sequence patterns and by herein identified sequence motifs defining TIR domain functional divergence. For example, BPPS identifies, in helices C and D of TIRAP and MyD88 orthologs, conserved surface-exposed residues apparently responsible for specificity of TIR domain interactions. In addition, BPPS clarifies the functional significance of the previously described Box 2 and Box 3 motifs, each of which is a part of a larger, group-specific block of conserved, intramolecularly interacting residues.
Pharmacogenetic investigation of efficacy response to mepolizumab in eosinophilic granulomatosis with polyangiitis
Authors: Condreay Lynn D. , Parham Laura R. , Qu Xiaoyan A. , Steinfeld Jonathan , Wechsler Michael E. , Raby Benjamin A. , Yancey Steven W. , Ghosh Soumitra 
Published: February 2020

AbstractTreatment of patients with the rare disease eosinophilic granulomatosis with polyangiitis (EGPA) with mepolizumab, a monoclonal antibody to interleukin-5 (IL-5) that reduces blood eosinophil counts, as an add-on therapy to glucocorticoid treatment, results in more accrued weeks in remission, reductions in glucocorticoid use and reductions in relapse rate. However, treatment response varies across a continuum. Therefore, to investigate if large genetic effects could identify responders, the impact of genetic variants on efficacy in EGPA subjects taking mepolizumab and glucocorticoids was assessed in this post hoc study. Using linear regression and a negative binomial model, genetic variant association with three endpoints (accrued duration of remission, average oral glucocorticoid dose, and frequency of relapse) was tested in 61 EGPA subjects dosed with mepolizumab from MIRRA, a phase 3 trial. Candidate gene and genome-wide approaches were used. The candidate gene analysis was designed to investigate drug target effects with eight gene regions selected that were focused on the intersection of the glucocorticoid response (steroidal response) and IL-5 response mechanisms and recognizing potential overlap between EGPA and severe eosinophilic asthma diseases for which mepolizumab is used. The sample size was insufficient to enable testing of rare variants for effects. No genetic variant from either the candidate gene analysis or the GWAS associated with any endpoint. Thresholds to declare significance were p < 0.0008 (candidate variant) and p < 2.5 × 10–8 (genome-wide) analyses. Large genetic effects on mepolizumab-treatment response were not identified which could help differentiate responders from non-responders.
Minimal ablative margin (MAM) assessment with image fusion: an independent predictor for local tumor progression in hepatocellular carcinoma after stereotactic radiofrequency ablation
Authors: Laimer Gregor , Schullian Peter , Jaschke Nikolai , Putzer Daniel , Eberle Gernot , Alzaga Amilcar , Odisio Bruno , Bale Reto 
Published: January 2020

AbstractObjectivesTo assess the minimal ablative margin (MAM) by image fusion of intraprocedural pre- and post-ablation contrast-enhanced CT images and to evaluate if it can predict local tumor progression (LTP) independently. Furthermore, to determine a MAM with which a stereotactic radiofrequency ablation (SRFA) can be determined successful and therefore used as an intraprocedural tool to evaluate treatment success.MethodsA total of 110 patients (20 women, 90 men; mean age 63.7 ± 10.2) with 176 hepatocellular carcinomas were assessed by retrospective analysis of prospectively collected data. The MAM was determined through image fusion of intraprocedural pre- and post-ablation images using commercially available rigid imaging registration software. LTP was assessed in contrast-enhanced CTs or MR scans at 3–6-month intervals.ResultsThe MAM was the only significant independent predictor of LTP (p = 0.036). For each millimeter increase of the MAM, a 30% reduction of the relative risk for LTP was found (OR = 0.7, 95% CI 0.5–0.98,p = 0.036). No LTP was detected in lesions with a MAM > 5 mm. The overall LTP rate was 9 of 110 (8.2%) on a patient level and 10 of 173 (5.7%) on a lesion level. The median MAM was 3.4 (1.7–6.9) mm. The mean overall follow-up period was 26.0 ± 10.3 months.ConclusionsAn immediate assessment of the minimal ablative margin (MAM) can be used as an intraprocedural tool to evaluate the treatment success in patients treated with stereotactic RFA. A MAM > 5 mm has to be achieved to consider an ablation as successful.Key Points• An intraoperatively measured minimal ablative margin (MAM) > 5 mm correlates with complete remission.• MAM is the only significant independent predictor of LTP (OR = 0.7, 95% CI 0.5–0.98, p = 0.036) after stereotactic RFA of hepatocellular carcinoma.• Image fusion using commercially available rigid imaging registration software is possible, even though considerably complex. Therefore, improved (semi-)automatic fusion software is highly desirable.
Outcomes in patients with dual antegrade conduction in the atrioventricular node: insights from a multicentre observational study
Authors: Hartmann Jens , Jungen Christiane , Stec Sebastian , Klatt Niklas , Willems Stephan , Makimoto Hisaki , Steven Daniel , Pürerfellner Helmut , Martinek Martin , Meyer Christian 
Published: January 2020

Abstract
Background
Supraventricular tachycardias induced by dual antegrade conduction via the atrioventricular (AV) node are rare but often misdiagnosed with severe consequences for the affected patients. As long-term follow-up in these patients was not available so far, this study investigates outcomes in patients with dual antegrade conduction in the AV node.

Methods and results
In this multicentre observational study, patients from six European centres were studied. Catheter ablation was performed in 17 patients (52 ± 16 years) with dual antegrade conduction via both AV nodal pathways between 2012 and 2018. Patients with the final diagnosis of a manifest dual AV nodal non-re-entrant tachycardia had a mean delay of the correct diagnosis of over 1 year (range 2–31 months). Two patients received prescription of non-indicated oral anticoagulation, two further patients suffered from inappropriate shocks of an implantable cardioverter defibrillator. In 12 patients, a co-existence of dual antegrade and re-entry conduction in the AV node was present. Mean fast pathway conduction time was 138 ± 61 ms and mean slow pathway conduction time was 593 ± 134 ms. Successful radiofrequency catheter ablation was performed in all patients. Post-procedurally oral anticoagulation was discontinued, without detection of cerebrovascular events or atrial fibrillation during a long-term follow-up of median 17 months (range 6–72 months).

Conclusion
This first multicentre study investigating patients with supraventricular tachycardia and dual antegrade conduction in the AV node demonstrates that catheter ablation is safe and effective while long-term patient outcome is good. Autonomic tone dependent changes in ante- vs. retrograde conduction via slow and/or fast pathway can challenge the diagnosis and therapy in some patients.

Graphic abstract
Healthy Nordic diet and risk of disease death among men: the Kuopio Ischaemic Heart Disease Risk Factor Study
Authors: Tertsunen Hanna-Mari , Hantunen Sari , Tuomainen Tomi-Pekka , Virtanen Jyrki K. 
Published: February 2020

Abstract
Purpose
To investigate the association between healthy Nordic diet and risk of disease death in middle-aged and older men from eastern Finland.

Methods
A total of 1547 men aged 42–60 years and free of cardiovascular disease (CVD), cancer and type 2 diabetes at baseline in 1984–1989 were included. Diet was assessed with 4-day food records at baseline and the healthy Nordic diet score was calculated based on the Baltic Sea Diet Score. The incidence of death was assessed by a computer linkage to the national cause of death register. Cox proportional hazards regression analyses were used to estimate the associations between the healthy Nordic diet score and mortality.

Results
During the mean follow-up of 23.6 years (SD 7.0), 576 men died due to disease: 250 due to CVD, 194 due to cancer and 132 due to other diseases. The multivariable-adjusted hazard ratios (95% confidence interval) in the lowest vs. the highest quartile of the healthy Nordic diet score were 1.27 (1.01–1.59) for any disease death (P-trend across quartiles < 0.001), 1.39 (0.99–1.97, P-trend = 0.049) for CVD death, 1.26 (0.84–1.89, P-trend = 0.316) for cancer death and 1.04 (0.65–1.68, P-trend = 0.563) for other disease deaths.

Conclusions
In this prospective population-based cohort study among middle-aged and older men, low adherence to a healthy Nordic diet was associated with a higher risk of any disease death, possibly largely attributable to higher CVD mortality.
From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models
Authors: Grune Jana , Beyhoff Niklas , Hegemann Niklas , Lauryn Jonathan H. , Kuebler Wolfgang M. 
Published: February 2020

AbstractTraditionally, the lung has been excluded from the ultrasound organ repertoire and, hence, the application of lung ultrasound (LUS) was largely limited to a few enthusiastic clinicians. Yet, in the last decades, the recognition of the previously untapped diagnostic potential of LUS in intensive care medicine has fueled its widespread use as a rapid, non-invasive and radiation-free bedside approach with excellent diagnostic accuracy for many of the most common causes of acute respiratory failure, e.g., cardiogenic pulmonary edema, pneumonia, pleural effusion and pneumothorax. Its increased clinical use has also incited attention for the potential usefulness of LUS in preclinical studies with small animal models mimicking lung congestion and pulmonary edema formation. Application of LUS to small animal models of pulmonary edema may save time, is cost-effective, and may reduce the number of experimental animals due to the possibility of serial evaluations in the same animal as compared with traditional end-point measurements. This review provides an overview of the emerging field of LUS with a specific focus on its application in animal models and highlights future perspectives for LUS in preclinical research.
Resection of the gastric submucosal tumor (G-SMT) originating from the muscularis propria layer: comparison of efficacy, patients’ tolerability, and clinical outcomes between endoscopic full-thickness resection and surgical resection
Authors: Liu Sha , Zhou Xinxin , Yao YongXing , Shi Keda , Yu Mosang , Ji Feng 
Published: February 2020

Abstract
Background and aims
Endoscopic full-thickness resection (EFTR) has been increasingly applied in the treatment of gastric submucosal tumors (G-SMTs) with explorative intention. This study aimed to compare the efficacy, tolerability, and clinical outcomes of EFTR and surgical intervention for the management of muscularis propria (MP)-derived G-SMTs.

Methods
Between September 2011 and May 2019, the clinical records of patients with MP-derived G-SMTs undergoing EFTR at our endoscopic unit were collected. A cohort of people with primary MP-derived G-SMTs treated by surgery was matched in a 1:1 ratio to EFTR group with regard to patients’ baseline characteristics, clinicopathologic features of the tumor and the procedure date. The perioperative outcomes and follow-up data were analyzed.

Results
In total, 62 and 62 patients were enrolled into the surgery and EFTR group, respectively, with median follow-up of 786 days. The size of G-SMTs (with ulceration) ranged from 10 to 90 mm. For patients with tumor smaller than 30 mm, surgery and EFTR group presented comparable procedural success rate (both were 100%), en bloc resection rate (100% vs. 94.7%), tumor capsule rupture rate (0% vs. 5.3%), and pathological R0 resection rate (both were 100%). EFTR had a statistically significant advantage over surgery for estimated blood loss (3.12 ± 5.20 vs. 46.97 ± 60.73 ml, p ≤ 0.001), discrepancy between the pre- and postprocedural hemoglobin level (5.18 ± 5.43 vs. 9.84 ± 8.25 g/L, p = 0.005), bowel function restoration [1 (0–5) vs. 3 (1–5) days, p ≤ 0.001], and hospital cost (28,617.09 ± 6720.78 vs. 33,963.10 ± 13,454.52 Yuan, p = 0.033). The patients with tumor larger than 30 mm showed roughly the same outcomes after comparison analysis of the two groups. However, the clinical data revealed lower en bloc resection rate (75.0% vs. 100%, p = 0.022) and higher tumor capsule rupture rate (25.0% vs. 0%, p = 0.022) for EFTR when compared to surgery. The procedure time, duration of postprocedural fasting and antibiotics usage, and hospital stay of the two groups were equivalent. The occurrence rate of adverse events within postoperative day 7 were 74.2% and 72.6% after EFTR and surgery, respectively (p = 1.000). No complications occurred during the follow-up.

Conclusion
For treatment of MP-derived G-SMTs (with or without ulceration), our study showed the feasibility and safety of EFTR, which also provided better results in terms of procedural blood loss, the postoperative bowel function restoration and cost-effectiveness when compared to surgery, whereas the surgery was superior in en bloc resection rate for G-SMTs larger than 30 mm. The postprocedural clinical outcomes seemed to be equivalent in these two resection methods.
Intragranular deformation mechanisms in calcite deformed by high-pressure torsion at room temperature
Authors: Schuster Roman , Habler Gerlinde , Schafler Erhard , Abart Rainer 
Published: February 2020

AbstractPolycrystalline calcite was deformed to high strain at room-temperature and confining pressures of 1–4 GPa using high-pressure torsion. The high confining pressure suppresses brittle failure and allows for shear strains >100. The post-deformation microstructures show inter- and intragranular cataclastic deformation and a high density of mechanicale$$ \left\{01\overline{1}8\right\} $$011¯8twins and deformation lamellae in highly strained porphyroclasts. The morphologies of the twins resemble twin morphologies that are typically associated with substantially higher deformation temperatures. Porphyroclasts oriented unfavorably for twinning frequently exhibit two types of deformation lamellae with characteristic crystallographic orientation relationships associated with calcite twins. The misorientation of the first deformation lamella type with respect to the host corresponds to the combination of oner$$ \left\{10\overline{1}4\right\} $$101¯4twin operation and one specificf$$ \left\{01\overline{1}2\right\} $$011¯2ore$$ \left\{01\overline{1}8\right\} $$011¯8twin operation. Boundary sections of this lamella type often split into two separated segments, where one segment corresponds to an incoherentr$$ \left\{10\overline{1}4\right\} $$101¯4twin boundary and the other to anf$$ \left\{01\overline{1}2\right\} $$011¯2ore$$ \left\{01\overline{1}8\right\} $$011¯8twin boundary. The misorientation of the second type of deformation lamellae corresponds to the combination of specificr$$ \left\{10\overline{1}4\right\} $$101¯4andf$$ \left\{01\overline{1}2\right\} $$011¯2twin operations. The boundary segments of this lamella type may also split into the constituent twin boundaries. Our results show that brittle failure can effectively be suppressed during room-temperature deformation of calcite to high strains if confining pressures in the GPa range are applied. At these conditions, the combination of successive twin operations produces hitherto unknown deformation lamellae.
A general framework for handling commitment in online throughput maximization
Authors: Chen Lin , Eberle Franziska , Megow Nicole , Schewior Kevin , Stein Cliff 
Published: February 2020

AbstractWe study a fundamental online job admission problem where jobs with deadlines arrive online over time at their release dates, and the task is to determine a preemptive single-server schedule which maximizes the number of jobs that complete on time. To circumvent known impossibility results, we make a standard slackness assumption by which the feasible time window for scheduling a job is at least $$1+\varepsilon $$

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times its processing time, for some $$\varepsilon >0$$

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>
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. We quantify the impact that different provider commitment requirements have on the performance of online algorithms. Our main contribution is one universal algorithmic framework for online job admission both with and without commitments. Without commitment, our algorithm with a competitive ratio of $$\mathcal {O}(1/\varepsilon )$$

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(
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is the best possible (deterministic) for this problem. For commitment models, we give the first non-trivial performance bounds. If the commitment decisions must be made before a job’s slack becomes less than a $$\delta $$
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-fraction of its size, we prove a competitive ratio of $$\mathcal {O}(\varepsilon /((\varepsilon -\delta )\delta ^2))$$

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, for $$0<\delta <\varepsilon $$

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. When a provider must commit upon starting a job, our bound is $$\mathcal {O}(1/\varepsilon ^2)$$

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. Finally, we observe that for scheduling with commitment the restriction to the “unweighted” throughput model is essential; if jobs have individual weights, we rule out competitive deterministic algorithms.