bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commonly Diagnosed Mental Disorders in a General Hospital System
Authors: Scott George , Beauchamp-Lebrón Alessandra , Rosa-Jiménez Ashley , Hernández-Justiniano Javier , Ramos-Lucca Axel , Asencio-Toro Gloria , Jiménez-Chávez Julio 
Published: November 2020

Abstract
Background: Considering many patients seek care from general hospitals, these healthcare institutions are uniquely situated to address comorbid mental and physical health needs. Little is documented, however, on the most common mental disorders in patients seeking care in general hospital settings, especially in Puerto Rico. The objective of this study was to characterize the five most common DSM-5 mental disorder diagnoses made in a hospital system in southern Puerto Rico between January 2015 and December 2019. Methods: A retrospective study of cross-sectional data obtained from 5,494 inpatients was implemented and a multinomial logistic regression was used to assess the odds of being diagnosed with a current mental disorder.Results: Overall, 53% of the entire sample was diagnosed with a mental disorder during hospitalization. Major depressive, neurocognitive, anxiety, substance-related and schizophrenia-spectrum disorders were the most frequently diagnosed. Interestingly, females were 23% less likely to have been diagnosed with major depressive disorder than males (aOR: .769, CI [.650, .909], p = .002). Thus, males evidenced 1.30 higher odds of being diagnosed with depression. Conclusion: The integration of clinical health psychology services within a general hospital facilitated our team’s work of identifying and treating co-occurring mental disorders among hospitalized patients. Future studies examining the opportunities and barriers of integrating clinical health psychology services within a general hospital’s administrative and clinical infrastructure for rapid identification and treatment of co-occurring mental disorders among medical patients are warranted.
Gm9795 Promotes Inflammation in Non-Alcoholic Steatohepatitis via NF-κB/JNK Pathway by Endoplasmic Reticulum Stress
Authors: Ye Liangying , Zhao Dan , Xu Yangzhi , Lin Jiaen , Xu Jiahui , Wang Kunyuan , Ye Zhanhui , Luo Yufeng , Liu Shiming , Yang Hui 
Published: November 2020

Abstract
Background: Non-alcoholic steatohepatitis (NASH) is a key stage in leading development of non-alcoholic simple fatty liver (NAFL) into cirrhosis and even liver cancer. This study aimed at exploring the lncRNA expression profifile in NASH and the biological function of a novel LncRNA-gm9795. Methods: Microarray analysis was performed to compare the expression profifiles of lncRNAs in the liver of NASH, NAFLD and normal mice. Methionine-choline-deficient Medium(MCD) with Lipopolysaccharide(LPS) or palmitic acid（PA）were used to built NASH cell models.The role and mechanism of LncRNA-gm9795 in NASH were explored by knocking down or over-expressing its expression. Results: A total of 381 lncRNAs were found to be not only highly expressed in NAFLD, but also is going to go even higher in NASH. A novel LncRNA-Gm9795 was significantly highly expressed in liver tissues of NASH animal models and NASH cell models. By staining with Nile red, we found that Gm9795 did not affect the fat accumulation of NASH. However, Gm9795 in NASH cell models significantly promoted the expression of TNFα, IL-6, IL-1β, the important inflammatory mediators in NASH. At the same time, we found that Gm9795 upregulated the key molecules in endoplasmic reticulum stress (ERS), while NF-κB/JNK pathways were also activated. When ERS activator Thapsigargin(TG) was introduced in cells with Gm9757 si-RNA, NF-κB and JNK pathways were activated. Conversely, ERS inhibitor Tauroursodeoxycholic(TUDCA) acid inhibited NF-kB and JNK pathways in cells with Gm9795 overexpression plasmid. Conclusion: LncRNA-gm9795 promotes inflammatory response in NASH through NF-kB and JNK pathways by ERS, which might provide theoretical basis for revealing the pathogenesis of NASH and discovering new therapeutic targets
Stereopsis Deficits in Parkinson’s Disease and Their Clinical Implications
Authors: Ba Fang , Sang Tina T. , Fatehi Jaleh , He Wenjing , Mostofi Emanuel , Zheng Bin 
Published: November 2020

Abstract
Background: Parkinson's disease (PD) is not exclusively a motor disorder. Among non-motor features, PD patients possess sensory visual dysfunctions. Stereopsis deficit can significantly impact patients' motor performance. However, it is not routinely tested, and its significance is under-investigated. Studying stereopsis using reliable 3D stimuli may help determine its implications in disease status in PD.The objective of the study is to investigate stereopsis abnormalities in PD with reliable and more physiological tools, and their correlation with indicators of PD severity. Methods: Twenty-four healthy control and 20 PD participants were first evaluated for visual acuity, visual field, contrast acuity, and stereoperception with 2D and Titmus stereotests, followed by the assessment with the 3D active shutter system. The correlation between stereopsis and disease severity, Unified Parkinson’s disease rating scale motor scores (UPDRS-III), levodopa equivalent daily dose (LEDD), course of disease and cognitive status were evaluated using univariate regression models. Results: Screening visual tests did not reveal any differences between PD and control group. With the 3D active shutter system, PD patients demonstrated significantly worse stereopsis (i.e p=0.002, 26 seconds of arc). There was a trend that UPDRS-III and LEDD negatively correlate with the stereo acuity, suggesting poorer stereoperception is related to disease severity. Preserved cognitive function correlated with more intact stereo acuity. Conclusion: With more reliable and physiological tools, PD patients exhibit poorer stereopsis. These deficits reflected PD motor and cognitive status. How stereopsis relates to gait, fall risks and navigation warrants more investigations in the future.
Analysis of IgM, IgA, and IgG Isotype Antibodies Directed Against SARS‑CoV‑2 Spike Glycoprotein and ORF8 in the Course of COVID‑19.
Authors: Meinberger Denise , Koch Manuel , Roth Annika , Hermes Gabriele , Stemler Jannik , Cornely Oliver A. , Streichert Thomas , Klatt Andreas R. 
Published: November 2020

Abstract
Immunoassays are a standard diagnostic tool assessing immunity in severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2) infection. However, immunoassays do not provide information about contaminating antigens or cross‑reactions and might exhibit inaccurately high sensitivity and low specificity. We aimed to gain insight into the serological immune response of SARS‑CoV‑2 patients by immunoblot analysis.We analyzed serum immunoglobulins IgM, ‑A, and ‑G directed against SARS‑CoV‑2 proteins by immunoblot analysis from 12 infected patients. We determined IgG isotype antibodies by commercially available ELISA and assessed the clinical parameters of inflammation status and kidney and liver injury.We found evidence for antibody cross‑reactivity, which calls into question a reliable assessment of serum samples tested negative for anti‑SARS‑CoV‑2 antibodies by immunoassays. Nevertheless, for the detection of IgG anti‑SARS‑CoV‑2 antibodies, our data suggest that the use of the spike glycoprotein in immunoassays should be sufficient to identify positive patients. Using a combination of the spike glycoprotein and the open reading frame 8 protein could prove to be the best for the detection of patients positive for anti‑SARS‑CoV‑2 IgM antibodies. We found that the antibody response alone is not decisive for the course of the disease, but inflammation parameters are promising indicators.
Evaluation of Myocardial Injury Patterns and ST Changes among Critical and Non-critical Patients with Coronavirus-19 Disease
Authors: Liaqat Anam , Ali-Khan Rao Saad , Asad Muhammad , Rafique Zakia , Hasan Syed Shahzad , Page Amy T , Qin Xiwen Simon 
Published: November 2020

Abstract
Background: Novel coronavirus disease (COVID-19) has led to a major public health crisis globally. Currently, myocardial damage is speculated to be associated with COVID-19, which can be seen as one of the main causes of death of patients with COVID-19. Therefore, in this study, we aim to investigate the effects of COVID-19 diagnosed patients on myocardial injury. Methods: A prospective study was conducted among 201 patients with COVID-19 in the Pakistan Military Hospital from April 1 to August 31, 2020, including non-critical cases and critical cases. COVID-19 patients were stratified as critical and non-critical according to signs and symptoms with those requiring intensive care and ventilator support as critical and those don’t require ventilator support as non-critical Results: A total of 201 COVID-19 patients with critical and non-critical categories presented with myocardial injury. All patients with myocardial injury had an elevation in CKMB and Trop 1 levels. Of these patients, 43.7% presented with new electrocardiography (ECG) changes, ST depression is observed in 36.3% patients, and 16.9% presented with abnormal electrocardiogram findings, with right ventricular dilatation and dysfunction. Results analyzed by a logistic regression model showing COVID-19 direct contribution to myocardial injury in these patients. Conclusion: COVID-19 disease directly leads to cardiovascular damage among critical and non-critical patients. Myocardial injury is associated not only with abnormal ECG changes but also with myocardial dysfunction on echocardiography and more commonly observed among critical patients.
A creatinine-based model to predict recurrent bleeding after modified percutaneous transhepatic variceal embolization in cirrhotic patients
Authors: Li Zhen , Ji Kun , Zhu Han-Long , Zhao Si , Li Xin , Zhan Peng-Chao , Shi Yang , Ye Shu-Wen , Xie Bing-Can , Zhang Yu-Yuan , Yu Peng , Ren Zhi-Gang , Ding Juan , Han Xin-Wei 
Published: November 2020

Abstract
Background: Patients who survived the initial esophagogastric variceal bleeding (EVB) experienced an increased risk of recurrent bleeding and death, but a reliable predictive model is lacking. We aim to develop and validate a model for rebleeding prediction in cirrhotic patients with EVB after modified percutaneous transhepatic variceal embolization (PTVE) with cyanoacrylate.Methods: A total of 122 patients with EVB who underwent PTVE from January 2015 to March 2020 were enrolled in this study. The multivariate logistic analyses were conducted to determine independent risk factors for nomogram construction. The discrimination, calibration and clinical utility of the nomogram were compared with the Model for End-stage Liver Disease (MELD) and Child–Pugh model. Additionally, a risk stratification was developed according to nomogram.Results: Rebleeding within 3 months after PTVE occurred in 32 patients (26.2%). The independent rebleeding indicators included the history of endoscopic therapy, Child–Pugh score, partial splenic embolization and creatinine level. The nomogram incorporating these four predictors achieved excellent calibration and discriminatory abilities with a concordance index of 0.85 which was confirmed to be 0.83 through bootstrapping validation. The nomogram harbored better discrimination and clinical applicability than the MELD and Child–Pugh model. As shown in the Kaplan-Meier curves, the patients at high risk were significantly associated with the high probability of rebleeding (P < 0.001). Conclusions: We created a creatinine-based nomogram to predict rebleeding in cirrhotic patients received PTVE, which could help clinicians to discern the high-risk patients to perform more aggressive treatments earlier and formulate intensive follow-up plan for them.
The study of laser deep penetration processing on prefabricated cracks of high carbon steel
Authors: Liu Dongwei , Shi Yan , Liu Jia 
Published: November 2020

Abstract
This paper describes the testing of laser deep penetration processing on controlled fragmentation of high carbon steel (50SiMnVB). The objective of this research is to make use of defects in deep penetration zones and optimize the quality of prefabricated cracks. The research shows that a deeper central crack appear in the deep penetration zone when the heat input is 60 J/mm, and the appeared crack is affected by martensite in microstructure, high microhardness and a high magnitude of tensile stress. Furthermore, the fracture mode of the deep penetration zones is mixed-mode (ductile and brittle fracture).
I see how you feel: facial expressions’ recognition and distancing in the time of COVID-19
Authors: Marta Calbi , Nunzio Langiulli , Francesca Ferroni , Martina Montalti , Anna Kolesnikov , Vittorio Gallese , Alessandra Umiltà Maria 
Published: November 2020

Abstract
The COVID-19 pandemic has dramatically changed the nature of our social interactions. In order to understand how protective equipment and distancing measures influence the ability to comprehend others’ emotions and, thus, to effectively interact with others, we carried out an online survey across the Italian population during the first pandemic peak. Participants were shown static facial expressions (Angry, Happy and Neutral) covered by a sanitary mask or by a scarf. They were asked to evaluate the expressed emotions as well as to assess the degree to which one would adopt physical and social distancing measures for each stimulus. Results demonstrate that, despite the covering of the lower-face, participants correctly recognized the facial expressions of emotions with a polarizing effect on emotional valence ratings found in females. Noticeably, while females’ ratings for physical and social distancing were driven by the emotional content of the stimuli, males were influenced by the “covered” condition. The results also show the impact of the pandemic on anxiety and fear experienced by participants. Taken together, our results offer novel insights on the impact of the COVID-19 pandemic on social interactions, providing a deeper understanding of the way people react to different kinds of protective face covering.
Perforator Preservation Technologies (PPT) Based on a New Neuro-interventional Classification in Endovascular Treatment of Perforator Involving Aneurysms (piAN)
Authors: Li Chen , Liu Ao-Fei , Qiu Han-Cheng , Lv Xianli , Zhou Ji , Zhang Yi-Qun , Lv Jin , Zhang Ying-Ying , Hu Sushan , Liu Fang , Liu Yun-e , Jin Min , Jiang Wei-jian 
Published: November 2020

Abstract
Background and Purpose Treatment of perforator involving aneurysm (piAN) remains a challenge to open and endovascular neurosurgeons. Our aim is to demonstrate a primary outcome of endovascular therapy for piANs with the use of perforator preservation technologies (PPT) based on a new neuro-interventional classification.Methods The piANs were classified into Type I: aneurysm really arises from perforating artery; Type II: saccular aneurysm involves perforating arteries arising from its neck (IIa) or dome (IIb); Type III: fusiform aneurysm involves perforating artery. Stent protection technology of PPT was applied in Type I and III aneurysms, and coil-basket protection technology in Type II aneurysms. Immediate outcome of aneurysmal obliteration after treatment was evaluated (Satisfactory Obliteration: The saccular aneurysm body is densely embolized (I), leaving a gap in the neck (IIa) or dome (IIb) where the perforating artery arising; fusiform aneurysm is repaired and has a smooth inner wall), and successful perforating artery preservation was defined as keeping good antegrade flow of those perforators on postoperative angiography. Periprocedural complication was closely monitored, and clinical and angiographic follow-up were performed.Results Six consecutive piANs (2 ruptured and 4 unruptured; 1 Type I, 2 Type IIa, 2 Type IIb and 1 Type III) in 6 patients (aged from 43 to 66 years; 3 males) underwent endovascular therapy between November 2017 and July 2019. The immediately angiography after treatment showed 6 aneurysms obtained satisfactory obliteration; and all of their perforating arteries were successfully preserved. During clinical follow-up of 13–50 months), no ischemic or hemorrhagic event of brain occurred in the 6 patients, but one who developed ischemic event in the territory of involving perforators 4 h after operation, and completely resolved within 24 h. Follow-up angiography at 3M to 10M showed patency of the parent artery and perforating arteries of treated aneurysms, with no aneurysmal recurrence.Conclusions Our perforator preservation technologies on basis of the new neuro-interventional classification seems feasible, safe and effective in protecting involved perforators while occluding aneurysm.
Transverse myelitis&nbsp;in COVID-19 patients: Report of two cases
Authors: Advani Soroor , Zali Alireza , Ommi Davood , Fatemi Alireza , Khoshnoud Reza Jalili , Ashrafi Farzad 
Published: November 2020

Abstract
Background: COVID-19 has been associated with several neurological complications. One of these complications is transverse myelitis. Several cases of acute transverse myelitis are reported in association with this disease among the world. As there is lack of knowledge about the association of COVID-19 and myelitis and the clinical features of this complication are still ambiguous, we report two patients with transverse myelitis following COVID-19 infection. Patients: This study was performed in a referral center of COVID-19 in Iran(Shohada Tajrish hospital) and two patients with paraparesis and diagnosis of transverse myelitis were enrolled. Both patients had longitudinally extensive transverse myelitis that resulted in paraparesis. One of the patients had favorable outcome after treatment with plasma exchange but the other had no improvement following treatment.Conclusion: Transverse myelitis could be a complication of COVID-19 and infarction and inflammation could be suggested as probable mechanisms for this condition.
COVID-19 progression in kidney transplant recipients: A single-center case series
Authors: Rahimzadeh Hormat , Keykhaei Mohammad , Razeghi Effat , Zivari Ensieh , Mansouri Ensieh Sadat 
Published: November 2020

Abstract
The novel coronavirus disease 2019 (COVID-19) is a respiratory infection that has received much attention due to its rapid expansion. Currently, it has been revealed that patients with underlying disease, especially those with kidney disease are more prone to develop complications. Some studies associate kidney transplantation as a risk factor for COVID-19 progression; however, epidemiologic data that demonstrate this are amazingly rare. Considering the importance of the topic, we report on six kidney transplant recipients (median age 47 [41-55]) with confirmed or clinically suspected COVID-19. The most common admission presentations were fever (83.3%), dyspnea, and myalgia. At baseline, immunosuppressive therapy was ceased, prednisolone dose was increased, and all patients received antiviral treatment including hydroxychloroquine and umifenovir. After a median follow-up of 11.5 days from admission, six patients (100%) developed acute kidney injury (AKI), 50% required intensive care unit (ICU) admission, and two patients (33.3%) deceased as a result of deterioration in respiratory status. Overall, these findings demonstrate that AKI development and respiratory involvement may be risk indicators of in-hospital mortality in kidney recipients with COVID-19. Therefore, more intensive attention should be paid to kidney transplant recipients with COVID-19.
Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer
Authors: IWAMA TAKUYA , Fujiya Mikihiro , Konishi Hiroaki , Tanaka Hiroki , Murakami Yuki , Kunogi Takehito , Sasaki Takahiro , Takahashi Keitaro , Ando Katsuyoshi , Ueno Nobuhiro , Kashima Shin , Moriichi Kentaro , Tanabe Hiroki , Okumura Toshikatsu 
Published: November 2020

Abstract
BACKGROUND: Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with the development and progression of colorectal cancer via these pathways. We identified Lactobacillus casei-derived ferrichrome as a mediator of the bacterial anti-tumor effect of colorectal cancer cells through the upregulation of DDIT3. In this study, we investigated the anti-tumor effects of ferrichrome on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer.METHODS: SRB and MTT assays were performed to assess growth inhibition in vitro. Eighteen organoids were prepared from biopsy specimens obtained by colonoscopy. An AOM-DSS carcinogenesis model and xenograft model of colorectal cancer cells were generated for the assessment of the tumor suppressive effect of ferrichrome in vivo. RESULTS: Ferrichrome inhibited the cell growth of colorectal cancer cells in vitro and in in vivo xenograft models. Ferrichrome exerted a strong tumor-suppressive effect that was superior to that of currently available anti-tumor agents, including 5-FU and cisplatin, both in vitro and in vivo. The tumor-suppressive effect of the combination of ferrichrome and 5-FU was superior to that of single treatment with either drug. The tumor suppressive effects of ferrichrome were confirmed through the upregulation of DDIT3 in patient-derived organoids of adenoma and carcinoma. Ferrichrome inhibited the tumor progression in the AOM-DSS model while exhibiting no anti-inflammatory effect in the DSS-colitis model, suggesting that ferrichrome inhibited cancer cells, but not a precancerous condition, via the colitis-associated pathway.CONCLUSIONS: Ferrichrome exerts a tumor suppressive effect on precancerous conditions and cancer cells associated with sporadic as well as colitis-associated colorectal cancer. The anti-tumor effect of ferrichrome was mediated by the upregulation of DDIT3, and was superior to that of 5-FU or cisplatin. These results suggest that Lactobacillus brevis-derived ferrichrome may be a candidate anti-tumor drug for the treatment of colorectal neoplasms.
Google analytics of a pilot study to characterize the visitor website statistics and implicate for enrollment strategies in Medical University
Authors: Chen Szu-Chieh , Tsao Thomas Chang-Yao , Lue Ko-Huang , Tsai Yafang 
Published: November 2020

Abstract
Background: Taiwan’s colleges and universities are struggling to maintain their student enrollment rates owing to the declining fertility rate. Focusing on students in higher education programs, this study aims to analyze online behavioral patterns for university departmental websites and accordingly, suggests response strategies to increase the rate of enrollment.Methods: We use Google Analytics to examine the websites of two departments in a medical university between February 1 and July 30, 2018. We study website patterns during the study periods for three college admission routes: STARS program, personal applications, and admission through examination and placement.Results: Most website visitors during the three visiting date ranges for the two departments are 18–24 years. The visitor groups are mainly freshmen at the university and their parents. The homepage and Subject Credits, Course Planning, Teacher Lineup, and Certificate of Subjects were the most visited webpages. The overall number of daily page views varied by academic event.Conclusions: University departments should enhance the presentation of featured courses on their webpage or distinguish course characteristics from those of competing departments in the curriculum to ensure clear market segmentation. In addition, departments should consider examining online data to identify suitable high schools that can be visited to attract potential students and to improve students’ willingness to choose their university.