bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of bendamustine and rituximab in unfit patients with previously untreated chronic lymphocytic leukemia. Indirect comparison with ibrutinib in a real‐world setting. A GIMEMA‐ERIC and US study
Authors: Cuneo Antonio , Mato Anthony R. , Rigolin Gian Matteo , Piciocchi Alfonso , Gentile Massimo , Laurenti Luca , Allan John N. , Pagel John M. , Brander Danielle M. , Hill Brian T. , Winter Allison , Lamanna Nicole , Tam Constantine S. , Jacobs Ryan , Lansigan Frederick , Barr Paul M. , Shadman Mazyar , Skarbnik Alan P. , Pu Jeffrey J. , Sehgal Alison R. , Schuster Stephen J. , Shah Nirav N. , Ujjani Chaitra S. , Roeker Lindsey , Orlandi Ester Maria , Billio Atto , Trentin Livio , Spacek Martin , Marchetti Monia , Tedeschi Alessandra , Ilariucci Fiorella , Gaidano Gianluca , Doubek Michael , Farina Lucia , Molica Stefano , Di Raimondo Francesco , Coscia Marta , Mauro Francesca Romana , de la Serna Javier , Medina Perez Angeles , Ferrarini Isacco , Cimino Giuseppe , Cavallari Maurizio , Cucci Rosalba , Vignetti Marco , Foà Robin , Ghia Paolo ,   the GIMEMA, European Research Initiative (ERIC) on CLL, US study group
Published: September 2020

AbstractLimited information is available on the efficacy of front‐line bendamustine and rituximab (BR) in chronic lymphocytic leukemia (CLL) with reduced renal function or coexisting conditions. We therefore analyzed a cohort of real‐world patients and performed a matched adjusted indirect comparison with a cohort of patients treated with ibrutinib. One hundred and fifty‐seven patients with creatinine clearance (CrCl) <70 mL/min and/or CIRS score >6 were treated with BR. The median age was 72 years; 69% of patients had ≥2 comorbidities and the median CrCl was 59.8 mL/min. 17.6% of patients carried TP53 disruption. The median progression‐free survival (PFS) was 45 months; TP53 disruption was associated with a shorter PFS (P = 0.05). The overall survival (OS) at 12, 24, and 36 months was 96.2%, 90.1%, and 79.5%, respectively. TP53 disruption was associated with an increased risk of death (P = 0.01). Data on 162 patients ≥65 years treated with ibrutinib were analyzed and compared with 165 patients ≥65 years treated with BR. Factors predicting for a longer PFS at multivariable analysis in the total patient population treated with BR and ibrutinib were age (HR 1.06, 95% CI 1.02‐1.10, P < 0.01) and treatment with ibrutinib (HR 0.55, 95% CI 0.33‐0.93, P = 0.03). In a post hoc analysis of patients in advanced stage, a significant PFS advantage was observed in patient who had received ibrutinib (P = 0.03), who showed a trend for OS advantage (P = 0.08). We arrived at the following conclusions: (a) BR is a relatively effective first‐line regimen in a real‐world population of unfit patients without TP53 disruption, (b) ibrutinib provided longer disease control than BR in patients with advanced disease stage.
Integrated genomic analysis identifies a genetic mutation model predicting response to immune checkpoint inhibitors in melanoma
Authors: Jiang Junjie , Ding Yongfeng , Wu Mengjie , Chen Yanyan , Lyu Xiadong , Lu Jun , Wang Haiyong , Teng Lisong 
Published: September 2020

AbstractSeveral biomarkers such as tumor mutation burden (TMB), neoantigen load (NAL), programmed cell‐death receptor 1 ligand (PD‐L1) expression, and lactate dehydrogenase (LDH) have been developed for predicting response to immune checkpoint inhibitors (ICIs) in melanoma. However, some limitations including the undefined cut‐off value, poor uniformity of test platform, and weak reliability of prediction have restricted the broad application in clinical practice. In order to identify a clinically actionable biomarker and explore an effective strategy for prediction, we developed a genetic mutation model named as immunotherapy score (ITS) for predicting response to ICIs therapy in melanoma, based on whole‐exome sequencing data from previous studies. We observed that patients with high ITS had better durable clinical benefit and survival outcomes than patients with low ITS in three independent cohorts, as well as in the meta‐cohort. Notably, the prediction capability of ITS was more robust than that of TMB. Remarkably, ITS was not only an independent predictor of ICIs therapy, but also combined with TMB or LDH to better predict response to ICIs than any single biomarker. Moreover, patients with high ITS harbored the immunotherapy‐sensitive characteristics including high TMB and NAL, ultraviolet light damage, impaired DNA damage repair pathway, arrested cell cycle signaling, and frequent mutations in NF1 and SERPINB3/4. Overall, these findings deserve prospective investigation in the future and may help guide clinical decisions on ICIs therapy for patients with melanoma.
Patient‐reported reasons for discontinuing psychotherapy in a low‐cost psychoanalytic community clinic
Authors: Cooke Jessica , Ivey Gavin , Godfrey Celia , Grady Jacqueline , Dean Suzanne , Beaufoy Jeanette , Tonge Bruce 
Published: September 2020

AbstractUsing data from an outcome study of adult individual psychoanalytic psychotherapy, conducted in a low‐cost Australian clinic, a mixed‐methods approach was employed to investigate patient discontinuation. This paper addresses the qualitative component of the discontinuation study, which explored patients’ reasons for leaving the clinic service upon assessment or in treatment proper. Of 205 patients commencing clinic contact, 41% discontinued during or shortly after the four‐week assessment period, while 40.5% of patients beginning psychotherapy withdrew before reaching the two‐year treatment limit. Across these two groups, former patients were interviewed about their therapy experience and decision to discontinue. Thematic analysis of 20 interview transcripts generated five descriptive categories of discomfort or dissatisfaction prompting discontinuation: clinic factors, therapist factors, patient factors, therapist–patient relationship factors and therapy factors. Findings suggest that experience of the clinic setting itself, together with negative patient perceptions of therapists and therapist interactional style, weres significant influences and that dissatisfaction with the psychotherapy process and outcome was more relevant than problematic patient factors in treatment withdrawal. A number of patients, mainly late discontinuers, reported positive experiences of psychotherapy and significant treatment gains. Implications of the findings, with specific emphasis on psychoanalytic treatment settings, are discussed.
Etoposide Loaded SPION‐PNIPAM Nanoparticles Improve the in vitro Therapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis
Authors: Erkisa Merve , Ari Ferda , Ulku Irem , Khodadust Rouhollah , Yar Yasemin , Yagci Acar Havva , Ulukaya Engin 
Published: September 2020

AbstractProstate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems to provide diverse options in this regard. Therefore, poly(N‐isopropylacrylamide) (PNIPAM) coated superparamagnetic iron oxide nanoparticles (SPION) loaded with Etoposide were prepared in small sizes (57 nm) and with 3.5 % drug content to improve the efficiency of Etoposide in prostate cancer therapy. Sustained release of the drug was achieved, which found to be sensitive to low pH and high temperature. The anti‐growth activity of SPION‐PNIPAM‐Etoposide formulation against metastatic prostate cancer cells (PC‐3, LNCaP) were investigated by SRB assay, then, confirmed by ATP assay. Mode of cell death was evaluated by using flow cytometry analyses. A significant improvement of nanoformulated drug was observed at 5–10 μg/ml doses of the drug in both cell lines. More importantly, this formulation enhanced the cytotoxic effect of Etoposide on PC‐3 cells, which is considered more resistant to Etoposide than LNCaP and reduced the IC50 value by 55 % reaching to 4.5 μg drug/ml, which is a very significant improvement in the literature. It was clearly shown that nanoformulated drug provided about 3‐fold increases in caspase‐dependent early apoptotic cells in PC‐3 cells. The novel formulation seems to successfully cause cell death of especially PC‐3 metastatic prostate cancer cells. It should therefore be taken into consideration for further animal studies as a novel potent anticancer agent.
Chemical Composition and Antiproliferative Effect of Essential Oils of Four Solidago Species (S. canadensis, S. gigantea, S. virgaurea and S.×niederederi)
Authors: Nkuimi Wandjou Joice Guileine , Quassinti Luana , Gudžinskas Zigmantas , Nagy David U. , Cianfaglione Kevin , Bramucci Massimo , Maggi Filippo 
Published: September 2020

AbstractThere is a growing interest in the research of natural products with potent activity in the prevention and treatment of diseases. Thereby, essential oil phytochemicals have demonstrated broad bioactivities. This study highlights the chemical composition of essential oils obtained from the leaves and inflorescences of diverse species of the genus Solidago (Solidago canadensis, Solidago gigantea, Solidago virgaurea and Solidago×niederederi), also known as Goldenrod, through GC/MS analysis, and their antiproliferative activity on three human tumor cell lines (MDA‐MB 231, A375 and HCT116) by the MTT assay. The most represented chemical classes in the essential oils were oxygenated sesquiterpenes, sesquiterpene hydrocarbons, oxygenated monoterpenes and monoterpene hydrocarbons, with a remarkable contribution of compounds such as germacrene D (3.89–19.51 %), α‐pinene (3.59–18.82 %), bornyl acetate (3.30–12.73 %) and caryophyllene oxide (3.07–9.18 %). Chemical quali‐ and quantitative differences were noticed between the leaves and flowers of the same species, as well as between the studied species. The MTT assay showed that the essential oils from the leaves were more active than those from the flower ones. The essential oil having the highest impact on cell viability was that from S.×niederederi (IC50=12.93, 6.72, and 6.82 μg/ml), followed by S. virgaurea (IC50=13.39, 7.96, and 8.36 μg/ml) and finally S. gigantea (IC50=18.04, 5.94, and 8.10 μg/ml) on MDA‐MB 231, A375 and HCT116 cell lines, respectively. The essential oil from S. canadensis showed the lowest activity (IC50=29.33, 12.63, and 18.03 μg/ml, respectively). Taken together, these findings highlight the Solidago species as good sources of cytotoxic compounds. Further studies are encouraged on the in vivo effects and safety of these products.
Fc‐Binding Antibody‐Recruiting Molecules Targeting Prostate‐Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement**
Authors: Sasaki Koichi , Harada Minori , Yoshikawa Takuma , Tagawa Hiroshi , Harada Yui , Yonemitsu Yoshikazu , Ryujin Takaaki , Kishimura Akihiro , Mori Takeshi , Katayama Yoshiki 
Published: September 2020

AbstractSynthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of therapeutic antibodies, such as immunogenicity and the need for intravenous delivery. Previously, we reported a novel class of bispecific molecules targeting the antibody Fc region and folate receptor, named Fc‐binding antibody‐recruiting molecules (Fc‐ARMs). Fc‐ARMs can theoretically recruit most endogenous antibodies, inducing antibody‐dependent cell‐mediated cytotoxicity (ADCC) to eliminate cancer cells. Herein, we describe new Fc‐ARMs that target prostate cancer (Fc‐ARM‐Ps). Fc‐ARM‐Ps recruited antibodies to cancer cells expressing prostate‐specific membrane antigen but did so with lower efficiency compared with Fc‐ARMs targeting the folate receptor. Upon recruitment by Fc‐ARM‐P, defucosylated antibodies efficiently activated natural killer cells and induced ADCC, whereas antibodies with intact N‐glycans did not. The results suggest that the affinity between recruited antibodies and CD16a, a type of Fc receptor expressed on immune cells, could be a key factor controlling immune activation in the Fc‐ARM strategy.
Potential risk of perioperative thromboembolism in patients with antiphospholipid syndrome who undergo transcatheter aortic valve implantation: A case series
Authors: Hoshi Tomoya , Hiraya Daigo , Sato Akira , Ieda Masaki 
Published: September 2020

AbstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by a positive serum antiphospholipid antibody status. Patients with APS usually have an underlying hypercoagulable state, which can increase the risk of perioperative thromboembolism. We describe three patients with APS who underwent transcatheter aortic valve implantation for symptomatic severe aortic stenosis. Of them, two had complicated cerebrovascular events, and the other had no complications. Careful antithrombotic management is essential to minimize the risk of thromboembolism and bleeding in patients with APS.
Agranulocytosis secondary to zinc excess: Clinically relevant observations, including response to G‐CSF and oral copper
Authors: Weiden Paul L. , Dunker Marlowe , Corwin David J. 
Published: September 2020

AbstractAnemia and leukopenia because of copper deficiency can be mistaken for myelodysplasia. Key issues, including response to G‐CSF and oral copper, are discussed. This case illustrates a significant deleterious effect of excessive zinc consumption.
A case of a superficial circumflex iliac perforator‐intercostal artery perforator (SCIP‐ICAP) compound flap for necrotizing soft tissue infection
Authors: Furuse Kiichi , Kato Motoi , Morishita Yuya , Kumagai Tomoyo , Nakatsukasa Shuichi , Kuwata Tomoyuki 
Published: September 2020

AbstractEven in NSTI patients with many comorbidities, it is possible to save both the life and the limb by thorough debridement and suitable reconstruction. SCIP‐ICAP compound flap can be versatile for a massive defect of an upper extremity. A Case of a Supercharged Compound Flap for Necrotizing Soft Tissue Infection
Liver transplantation after DRESS syndrome: A case report and review of the literature
Authors: Calil Igor Lepski , Tustumi Francisco , Pinheiro Rafael Soares Nunes , Tanigawa Ryan Yukimatsu , Cruz Junior Ruy Jorge , Bento de Sousa Jorge Henrique , Pecora Rafael Antônio Arruda , D'Albuquerque Luiz Augusto Carneiro 
Published: September 2020

AbstractThis study reports a patient with DRESS syndrome, associated with liver failure, treated with orthotopic liver transplantation.
AuxPd(300‐x) Alloy Nanoparticles for the Oxygen Reduction Reaction in Alkaline Media
Authors: Trindell Jamie A. , Duan Zhiyao , Henkelman Graeme , Crooks Richard M. 
Published: September 2020

AbstractAuxPd(300‐x) nanoalloys were prepared using a dendrimer‐templating method and their electrocatalytic efficiencies towards the oxygen reduction reaction (ORR) were analyzed in alkaline media. The composition‐dependent PdOx reduction potentials of the AuxPd(300‐x) nanoalloys were correlated to the oxygen‐binding (O‐binding) energy of the catalysts. Multiple PdOx reduction peaks were present for the Au150Pd150 and Au50Pd250 catalysts. These peaks were assigned to the alloyed and bulk‐like Pd active sites on the alloyed surface. The results described here are significant because modulation of the O‐binding energies improved the ORR activity on the nanoalloys. Specifically, a linear trend in O‐binding energies of AuxPd(300‐x) dendrimers (DENs) as a function of Pd composition resulted in a volcano‐shaped trend in ORR activity. The optimal O‐binding energy of Au50Pd250 resulted in an approximate 89 mV shift in PdOx reduction relative to Pd300 and a shift of approximately 76 mV in ORR peak potential.
Design, Synthesis, and Electrochromic Behaviors of Donor‐Acceptor‐Donor type Triphenylamine‐iso‐Naphthalenediimide Derivatives
Authors: Nad Subhra , Malik Sudip 
Published: September 2020

AbstractTo investigate the influence of number of electropolymerizable group of the donor side on electrochromic behaviors, three donor‐acceptor‐donor type monomers containing isonaphthalene diimide as acceptor core and electro‐polymerizable triphenyl amine (TPA) as the donor moiety have been designed and successfully synthesized via imidization of isonaphthalene anhydride with corresponding TPA derivatives. DFT calculations have predicted that electron density of HOMO is centralized on peripheral TPA unit and the same of LUMO is localized on central moiety. Polymer films from three monomers are electrodeposited on ITO/glass electrodes and have been characterized by cyclic voltammetry. Three polymers show multi electrochromic properties in a reversible manner with the color change from colorless to brown to blue at low working potential. Spectro‐electrochemistry studies of these films have revealed the high optical contrast (51.4 %, 69.8 %, 84.5 % respectively) of these polymers with the very fast bleaching (less than 1 s) and coloration (less than 2 s) time with very high coloration efficiencies. The electro switching stability has been performed up to 500 cycles and activity loses only 10 % after 3000 s. To demonstrate the potentials of these derivatives, solid‐state devices having these derivatives provide electrochromism in a very nice way without taking any protective precaution from air/moisture and its spectro‐electrochemistry behaviors have been also explored.
Merging Natural Products: Muraymycin–Sansanmycin Hybrid Structures as Novel Scaffolds for Potential Antibacterial Agents
Authors: Niro Giuliana , Weck Stefanie C. , Ducho Christian 
Published: September 2020

AbstractTo overcome bacterial resistances, the need for novel antimicrobial agents is urgent. The class of so‐called nucleoside antibiotics furnishes promising candidates for the development of new antibiotics, as these compounds block a clinically unexploited bacterial target: the integral membrane protein MraY, a key enzyme in cell wall (peptidoglycan) biosynthesis. Nucleoside antibiotics exhibit remarkable structural diversity besides their uridine‐derived core motifs. Some sub‐classes also show specific selectivities towards different Gram‐positive and Gram‐negative bacteria, which are poorly understood so far. Herein, the synthesis of a novel hybrid structure is reported, derived from the 5′‐defunctionalized uridine core moiety of muraymycins and the peptide chain of sansanmycin B, as a new scaffold for the development of antimicrobial agents. The reported muraymycin–sansanmycin hybrid scaffold showed nanomolar activity against the bacterial target enzyme MraY, but displayed no significant antibacterial activity against S. aureus, E. coli, and P. aeruginosa.
Exciton Transport in Molecular Semiconductor Crystals for Spin‐Optoelectronics Paradigm
Authors: Zhu Weigang , Sun Yajing , Liu Jie , Bai Shuming , Zhang Zhicheng , Shi Qiang , Hu Wenping , Fu Hongbing 
Published: September 2020

AbstractOrganic semiconductors with long‐range exciton diffusion length are highly desirable for optoelectronics but currently remain rare. Here, the estimated diffusion length of singlet excitons (LD) in 2,6‐diphenyl anthracene (DPA) crystals grown by solvent evaporation was shown to be up to approximately 124 nm. These crystals showed a previously unseen parallelogram morphology with layer‐by‐layer edge‐on molecular stacking, isotropic optical waveguiding, radiation rate and non‐radiation rate constants of 0.15 and 0.26 ns−1 respectively, as well as good field‐effect transistor hole mobility and theoretically computed strong electronic couplings as high as 109 meV. Photoresponse experiments revealed that the photoconductivity of DPA crystals is surprisingly not related to the radiative pathway but associated with rapid exciton diffusion to the crystal surface for charge separation and carrier bimolecular recombination. Taken together, DPA was shown to be a promising semiconducting material for a new organic optoelectronics paradigm.
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
Authors: Chen Tzu‐Yu , Chen Jinfeng , Tang Yijie , Zhou Jiahai , Guo Yisong , Chang Wei‐chen 
Published: September 2020

AbstractIsonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile‐containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.
Preventing smoking relapse in patients with cancer: A randomized controlled trial
Authors: Simmons Vani N. , Sutton Steven K. , Meltzer Lauren R. , Martinez Ursula , Palmer Amanda M. , Meade Cathy D. , Jacobsen Paul B. , McCaffrey Judith C. , Haura Eric B. , Brandon Thomas H. 
Published: September 2020

BackgroundAbstaining from smoking after a cancer diagnosis is critical to mitigating the risk of multiple adverse health outcomes. Although many patients with cancer attempt to quit smoking, the majority relapse. The current randomized controlled trial evaluated the efficacy of adapting an evidence‐based smoking relapse prevention (SRP) intervention for patients with cancer.MethodsThe trial enrolled 412 patients newly diagnosed with cancer who had recently quit smoking. Participants were randomized to usual care (UC) or SRP. Participants in the UC group received the institution's standard of care for treating tobacco use. Participants in the SRP group in addition received a targeted educational DVD plus a validated self‐help intervention for preventing smoking relapse. The primary outcome was smoking abstinence at 2 months, 6 months, and 12 months.ResultsAbstinence rates for participants in the SRP and UC groups were 75% versus 71% at 2 months and 69% versus 64% at 6 months (Ps > .20). At 12 months, abstinence rates among survivors were 68% for those in the SRP group and 63% for those in the UC group (P = .38). Post hoc analyses revealed that across 2 months and 6 months, patients who were married/partnered were more likely to be abstinent after SRP than UC (P = .03).ConclusionsA smoking relapse prevention intervention did not reduce relapse rates overall, but did appear to have benefited those participants who had the social support of a partner. Future work is needed to extend this effect to the larger population of patients.
Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters
Authors: Tarigopula Anil , Chandrashekar Vani , Perumal Govindasami 
Published: September 2020

AbstractBackgroundRecurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR‐ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR ‐ABL ‐ is the commonest recurrent abnormality whereas, IgH rearrangements are rare.AimAim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings.MethodsBone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests.ResultsBCR‐ABL positive group had a higher leukocyte count than BCR‐ABL negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. BCR‐ABL is commonest recurrent abnormality followed by IgH rearrangements.ConclusionPatients with gains of chromosomes alone have low total leukocyte counts at presentation.