bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multielectrode Cortical Stimulation Selectively Induces Unidirectional Wave Propagation
Authors: Halgren Alma , Siegel Zarek , Golden Ryan , Bazhenov Maxim 
Published: November 2020

ABSTRACTCortical stimulation is emerging as an experimental tool in basic research and a promising therapy for a range of neuropsychiatric conditions. As multielectrode arrays enter clinical practice, the possibility of using spatiotemporal patterns of electrical stimulation to induce desired physiological patterns has become theoretically possible, but in practice can only be implemented by trial-and-error because of a lack of predictive models. Experimental evidence increasingly establishes travelling waves as fundamental to cortical information-processing, but we lack understanding how to control wave properties despite rapidly improving technologies. This study uses a hybrid biophysical-anatomical and neural-computational model to predict and understand how a simple pattern of cortical surface stimulation could induce directional traveling waves via asymmetric activation of inhibitory interneurons. It reveals local circuit mechanisms to control spatiotemporal cortical dynamics and predicts interventions that can be developed to treat a broad range of cognitive disorders.
SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response thanTP53mutation status
Authors: Fujihara Kenji M. , Corrales-Benitez Mariana , Cabalag Carlos S. , Zhang Bonnie Z. , Ko Hyun S. , Liu David S. , Simpson Kaylene , Haupt Ygal , Haupt Sue , Phillips Wayne A. , Clemons Nicholas J. 
Published: November 2020

ABSTRACTPurposeAPR-246 (Eprenetapopt) is in clinical development with a focus on haematological malignancies and is marketed as a mutant-p53 reactivation therapy. Currently, the detection of at least oneTP53mutation is an inclusion criterion for patient selection into most clinical trials. Preliminary results from our phase Ib/II clinical trial investigating APR-246 combined with combination chemotherapy (cisplatin and 5-Fluorouracil) in metastatic oesophageal cancer, together with previous pre-clinical studies, indicate thatTP53mutation status alone may not be a sufficient biomarker for response to APR-246. This study aimed to identify a robust biomarker for response to APR-246.MethodsCorrelation analysis of the PRIMA-1 activity (lead compound to APR-246) with mutational status, gene expression, protein expression and metabolite abundance across over 800 cancer cell lines was performed. Functional validation and a boutique siRNA screen of over 750 redox-related genes were also conducted.ResultsTP53mutation status was not predictive of response to APR-246. The expression of SLC7A11, the cystine/glutamate transporter, was identified as a superior determinant of response to APR-246. Genetic regulators of SLC7A11, including ATF4, MDM2, wild-type p53 and c-Myc were confirmed to also regulate cancer cell sensitivity to APR-246.ConclusionsSLC7A11 expression is the major determinant of sensitivity to APR-246 and should be utilised as a predictive biomarker in future clinical investigation of APR-246.
Coupling of mouse olfactory bulb projection neurons to fluctuating odour pulses
Authors: Dasgupta Debanjan , Warner Tom P.A. , Erskine Andrew , Schaefer Andreas T. 
Published: November 2020

AbstractOdours are transported by turbulent air currents, creating complex temporal fluctuations in odour concentration. Recently, we have shown that mice can discriminate odour stimuli based on their temporal structure, indicating that information present in the temporal structure of odour plumes may be extracted by the mouse olfactory system. Here usingin vivoelectrophysiological recordings, we show that mitral and tufted cells (M/TCs), the projection neurons of the mouse olfactory bulb, can encode the dominant temporal frequencies present in odour stimuli up to frequencies of at least 20 Hz. We show that M/TCs couple their membrane potential to odour concentration fluctuations; coupling was variable between M/TCs but independent of the odour presented and with TCs displaying slightly elevated coupling compared to MCs in particular for higher frequency stimulation (20Hz). Pharmacologically blocking the inhibitory circuitry strongly modulated frequency coupling. Together this suggests that both cellular and circuit properties contribute to the encoding of temporal odour features in the mouse olfactory bulb.
Typical traceability barriers in the Indonesian vegetable oil industry
Authors: Gunawan Ivan , Vanany Iwan , Widodo Erwin 
Published: November 2020

PurposeA traceability system is a key success factor in global food trade, but implementing it in vegetable oil industry is one of the most difficult undertakings in food supply chain management. This study aims to (1) identify typical operational barriers in the implementation of bulk-liquid traceability system in the Indonesian vegetable oil industry by considering the perspective of experts and (2) model the relationship between the barriers structurally in order to improve the reliability of the traceability system.Design/methodology/approachTo do so, data from in-depth interviews with experts were examined by using content analysis. Then the authors used a combination of decision-making trial and evaluation laboratory (DEMATEL), interpretive structural modelling (ISM) and matrice d'impacts croisés multiplication appliqué un classement (MICMAC) to construct the hierarchical model and to cluster the typical barriers based on their driving power and dependence power.FindingsIn total, 20 typical traceability barriers along the internal chain (supplier-input-process-output-customer) were identified. The interrelationships between these barriers were modeled in a hierarchical structure, seeking to answer why it is difficult to implement a traceability system and what actions should be taken to remove these barriers.Practical implicationsThe model can shed light on how to manage barriers in bulk-liquid food commodity industry, especially in the vegetable oil industry. An action map has been proposed to overcome the operational barriers. This model will also help tracing the critical points of the traceability system.Originality/valueCompared to other food commodities, operational barriers in vegetable oil chain has never been studied specifically. In fact, there are many operational aspects that hinder traceability. The Indonesian context entails social, economic and environmental factors as well, so it can inform decision-makers in formulating an action map.
The effect of total quality management-enabling factors on corporate social responsibility and business performance: evidence from Vietnamese coffee firms
Authors: Do Manh-Hoang , Huang Yung-Fu , Do Thi-Nga 
Published: November 2020

PurposeThis article aims to evaluate total quality management (TQM)-enabling factors' impact on corporate social responsibility (CSR) activities and business performance through evidence from Vietnamese coffee firms.Design/methodology/approachBased on collecting data via in-depth face-to-face interviews with employees, who are working in the Vietnamese coffee companies. The partial least squares structural equation modeling (PLS-SEM) approach has been employed to investigate the relationship among the TQM-enabling factors, corporate social performance (CSP) and business performance.FindingsA total of 13 TQM-enabling factors have been identified and divided into two categories, namely human and functional. The statistical results revealed a positive signal to remarkably enhance CSP and business performance by adopting those TQM-enabling factors into Vietnamese coffee firms.Research limitations/implicationsThe framework model of this research should be evaluated in different contexts worldwide or in another sector that can further identify the TQM-enabling factor and the correlation among these constructs.Practical implicationsThis article provides top managers of Vietnamese coffee firms with knowledge of TQM-enabling factors that may enable them to meet superior performance, including CSP, finance and reputation.Originality/valueThis is a unique study to employ the approach into the Vietnamese coffee industry context up-to-date, which is one of the essential sectors affecting Vietnam's sustainable development.
Who benefits from time-spatial job crafting? The role of boundary characteristics in the relationship between time-spatial job crafting, engagement and performance
Authors: Lazauskaite-Zabielske Jurgita , Ziedelis Arunas , Urbanaviciute Ieva 
Published: November 2020

PurposeUsing the theoretical framework of job demands-resources and boundary management, the purpose of this paper is to explore the moderating role of work and life boundary characteristics in the relationship between time-spatial job crafting, work engagement and job performance.Design/methodology/approachA total of 176 employees working in the IT sector and having an opportunity to use flexible work arrangements were surveyed online.FindingsWork and life boundary characteristics were found to moderate the relationship between time-spatial job crafting and work engagement as well as between time-spatial job crafting and job performance. Moreover, boundary characteristics moderated the indirect relationship between time-spatial job crafting and job performance through work engagement.Practical implicationsTime-spatial job crafting becomes a key strategy for maintaining work engagement and job performance, when work–life boundaries are less flexible and less permeable.Originality/valueThe study demonstrates that boundary characteristics determine the effects of time-spatial job crafting on work engagement and job performance.
Application of analytic hierarchy process (AHP) for sustainable pavement performance management in Qatar
Authors: Sirin Okan , Gunduz Murat , Shamiyeh Mohammed E. 
Published: November 2020

PurposePavement is one of the main elements of the roads network. It is extremely essential to study and understand the factors affecting its performance and highlight the most important ones for decision-makers and pavement experts to consider during the design, construction and maintenance stages. The purpose of this paper was to identify the factors affecting pavement performance and rank them according to their importance using Analytic Hierarchy Process (AHP) for decision-makers and pavement experts to consider during the design, construction and maintenance stages.Design/methodology/approachA survey was developed considering 29 factors found in the literature that affect pavement performance. The survey was sent to pavement professionals in Qatar to rate their perception of factors affecting pavement performance to enhance roads' sustainability. 205 responses were collected and analyzed using AHP.FindingsThe findings indicate that the factor “unconsidered heavy vehicles volume” is the most critical factor that affects pavement performance. The second most critical factor affecting the pavement performance is the “low asphalt content” due to escalating binder aging, reducing fatigue life of the pavement and decreasing the durability of roads. The third and fourth factors are “poor mechanical and thermal properties” and “unexpected high traffic volume,” respectively. These two factors are strongly attached to the first and second factors since the traffic volume affects the pavement performance less but similar to the heavy vehicles and a mix with poor mechanical and thermal properties is related indirectly to the asphalt content in the mix.Originality/valueThe research provides help for decision-makers in the construction industry to improve the performance of pavements using a multi-criteria decision-making tool. This paper's outcome would help the pavement management professionals in the construction industry to improve pavement performance and management, increase the pavement's life cycle and reduce maintenance costs.
An immersive performative architectural design tool with daylighting simulations: a building information modeling-based approach
Authors: Akin Sahin , Ergun Oguzcan , Surer Elif , Gursel Dino Ipek 
Published: November 2020

PurposeIn performative architectural design, daylighting is a crucial design consideration; however, the evaluation of daylighting in the design process can be challenging. Immersive environments (IEs) can create a dynamic, multi-sensory, first-person view in computer-generated environments, and can improve designers' visual perception and awareness during performative design processes. This research addresses the need for interactive and integrated design tools for IEs toward better-performing architectural solutions in terms of daylighting illumination. In this context, building information modeling and performance simulations are identified as critical technologies to be integrated into performative architectural design.Design/methodology/approachThis research adopts a design science research (DSR) methodology involving an iterative process of development, validation and improvement of a novel and immersive tool, HoloArch, that supports design development during daylighting-informed design processes. HoloArch was implemented in a game engine during a spiral software development process. HoloArch allows users to interact with, visualize, modify and explore architectural models. The evaluation is performed in two workshops and a user study. A hybrid approach that combines qualitative and quantitative data collection was adopted for evaluation. Qualitative data analyses involve interviews, while quantitative data analyses involve both daylighting simulations and questionnaires (e.g. technology acceptance model (TAM), presence and system usability scale (SUS)).FindingsAccording to the questionnaire results, HoloArch had 92/100 for SUS, a mean value of 120.4 for presence questionnaire (PQ) and 9.4/10 for TAM. According to the simulation results, all participants improved the given building's daylighting performance using HoloArch. The interviews also indicated that HoloArch is an effective design tool in terms of augmented perception, continuous design processes, performative daylighting design and model interaction. However, challenges still remain regarding the complete integration of tools and simultaneous simulation visualization. The study concludes that IEs hold promising potentials where performative design actions at conceptual, spatial and architectural domains can take place interactively and simultaneously with immediate feedback.Originality/valueThe research integrates building information modeling (BIM), performative daylighting simulations and IEs in an interactive environment for the identification of potentials and limitations in performative architectural design. Different from existing immersive tools for architecture, HoloArch offers a continuous bidirectional workflow between BIM tools and IEs.
ICICI Prudential: challenges in reaching the last mile
Authors: Das Parthasarathi , Moharana Tapas Ranjan , Indibara Indirah 
Published: November 2020

Learning outcomes
The specific learning objectives of the case are as follows: To contribute to the knowledge of environmental challenges faced by various financial companies while trying to foray into the rural markets, especially in case of insurance products’ expansion strategy; to understand the distribution strategy adopted by insurance companies in rural as well as urban markets; to apply the concepts such as mental accounting, designing and pricing of insurance products to develop an effective strategy for insurance products targeting the rural market; to be able to analyse the data available on products and the rural market structure that enables the students to derive from an implementable managerial framework and design an effective rural market strategy for insurance products; and to enable the students to evaluate the key rural market drivers, which will subsequently help them to develop a new structure of rural distribution channel.

Case overview/synopsis
ICICI Prudential Life Insurance Company Limited (IPRU) was trying to reach the last mile customers of rural India to tap the opportunity and meet the Indian Government's statutory requirement of financial inclusion. Even though the leadership of IPRU was optimistic about the untapped potential of rural India, and launched a separate business vertical - Rural Business Channel (RBC) in the year 2002 to cater to this target segment, yet it faced many strategic issues while foraying into the rural domain. The company struggled with both the designing of products as per the rural customers' needs, as well as the distribution of these products in rural areas. The present case study is an attempt to bring out the strategic challenges that were faced by the IPRU management, with a major focus on designing, pricing and distribution of rural insurance products. The case study will help the readers in understanding what might go wrong while entering new rural markets and how to deal with these challenges.

Complexity academic level
The case study can be used to teach both undergraduate and postgraduate management students.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 8: Marketing.
Factors influencing consumer attitudes toward online shopping: the mediating effect of trust
Authors: Chetioui Youssef , Lebdaoui Hind , Chetioui Hajar 
Published: November 2020

PurposeThe coronavirus pandemic has created a new wave of first-time online shoppers in both industrialized and emerging countries. More interestingly, scholars and practitioners expect this transition to online shopping to eventually persist in the next few years. The current research study aims to investigate the factors explaining attitudes toward online shopping. The authors propose an integrated model in which trust mediates the effects of relative advantage and electronic word of mouth (eWOM) on attitudes toward online shopping. The moderating effect of gender was also assessed using the multigroup analysis (MGA).Design/methodology/approachBased on data collected from 378 Moroccan online shoppers, the authors empirically tested the hypothesized model using a partial least squares (PLS) estimation.FindingsFirst, relative advantage, eWOM and trust significantly impact consumer attitudes toward online shopping; at the same time, trust is influenced by relative advantage and eWOM. Second, results confirm that trust mediates the effects of relative advantage and eWOM on attitudes toward online shopping. Third, the MGA reveals that female consumers tend to exhibit a stronger effect of eWOM on trust and on attitudes toward online shopping.Originality/valueMost relevant studies have focused on the main predictors of attitudes toward online shopping but did not suggest mediating and moderating factors that can help in explaining indirect effects. The present paper bridges a gap pertaining to antecedents of attitudes toward online shopping by incorporating the mediating effect of online trust. The authors also examine gender disparities related to the predictors of trust and consumer attitudes toward online shopping. This study is the first of its kind to investigate the antecedents of attitudes toward online shopping in an African country.
Are online job quality quizzes of any value? Selecting questions, maximising quiz completions and estimating biases
Authors: Felstead Alan 
Published: November 2020

PurposeThe purpose of this paper is to compare two ways of collecting job quality data in Britain using a common set of questions. One way is through a short quiz taken by a self-selected sample and completed by clicking on a web link www.howgoodismyjob.com. The other way is via an invitation to take part in a long-running survey of working life – the Skills and Employment Survey. The survey takes much longer to complete, is carried out face-to-face and is based on random probability principles.Design/methodology/approachTo be content-comparable, the quiz uses tried and tested questions contained in recent waves of the Skills and Employment Survey. Each survey comprises a nationally representative sample of workers in Britain aged 20–65 years. However, the quiz is based on uncontrolled convenience sampling prompted, in large part, by a Facebook advertising campaign, whereas survey participants are randomly selected. In this paper, the authors compare the profile of respondents and their responses to these two different modes of data collection and therefore shine a light on any biases in the samples and differences in the results respondents report.FindingsThe paper shows that while the number taking in the quiz is impressive, participation in the quiz – unlike the survey – is heavily skewed. Weighting can be used to correct some of these sample selection biases. But, even then, the picture painted by the quiz and survey data varies with the quiz under-reporting the intrinsic quality of jobs, while over-reporting on the extrinsic rewards. This suggests that how job quality data are collected can have a strong influence on the results produced.Research limitations/implicationsThe findings suggest that a number of biases are in operation, both in terms of those who take part and the answers they give. This makes comparison between data collected using radically different methods, at best, inadvisable and, at worst, misleading. Nevertheless, quizzes are a good way of engaging large numbers of people in public debates, gathering additional data, extending the reach of academic work and prompting action to improve working life. However, the limitation of this study is that it does not offer a true experiment of different ways of collecting the same data. The quiz and survey were, for example, not carried out at the same time, but were some 14 months apart.Practical implicationsOver 50,000 people took part in the quizzes reported in the paper and almost 1,300 investigated joining a trade union as a result. The reach of the quiz far exceeds the 3,306 people who took part in the Skills and Employment Survey 2017.Originality/valueThis paper focusses on how job quality data are collected and the consequences this has for the validity of the data gathered. This is a unique contribution to international debates about the measurement and monitoring of trends in job quality.