bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can auditory warning signals normalize eye movements in children with ADHD?
Authors: Kleberg Johan Lundin , Frick Matilda A. , Brocki Karin C. 
Published: February 2020

AbstractAttenuated baseline arousal has been hypothesized to underlie symptoms of attention deficit/hyperactivity disorder (ADHD). A behavioral signature of reduced baseline arousal is an increased beneficiary effect of warning signals in reaction tasks. This paradoxical effect is believed to be caused by a temporary increase in arousal induced by warning signals. In a preregistered study, we tested the hypothesis that children with high levels of ADHD symptoms would be hyperresponsive to warning signals in a well-established visual attention task (the gap/overlap paradigm). Previous studies using this task have found slower and more variable saccadic reaction times in children with ADHD compared to typically developing children, suggesting that these eye movement metrics are candidate biomarkers. We examined 71 children, of which 1/3 had a diagnosis of ADHD, using both dimensional analyses and group comparisons. Previously reported findings of reduced saccadic latency and increased latency variability were replicated. Importantly, saccadic latency was normalized by auditory warning signals. Analyses of pupil dilation, a physiological index of arousal and locus coeruleus-noradrenergic activity, confirmed that warning signals led to enhanced arousal. Our findings are novel and contribute to our understanding of arousal and attention in ADHD and have implications for treatment and interventions.
Poor perfusion of the microvasculature in peritoneal metastases of ovarian cancer
Authors: Kastelein Arnoud W. , Vos Laura M. C. , van Baal Juliette O. A. M. , Koning Jasper J. , Hira Vashendriya V. V. , Nieuwland Rienk , van Driel Willemien J. , Uz Zühre , van Gulik Thomas M. , van Rheenen Jacco , Ince Can , Roovers Jan-Paul W. R. , van Noorden Cornelis J. F. , Lok Christianne A. R. 
Published: February 2020

AbstractMost women with epithelial ovarian cancer (EOC) suffer from peritoneal carcinomatosis upon first clinical presentation. Extensive peritoneal carcinomatosis has a poor prognosis and its pathophysiology is not well understood. Although treatment with systemic intravenous chemotherapy is often initially successful, peritoneal recurrences occur regularly. We hypothesized that insufficient or poorly-perfused microvasculature may impair the therapeutic efficacy of systemic intravenous chemotherapy but may also limit expansive and invasive growth characteristic of peritoneal EOC metastases. In 23 patients with advanced EOC or suspicion thereof, we determined the angioarchitecture and perfusion of the microvasculature in peritoneum and in peritoneal metastases using incident dark field (IDF) imaging. Additionally, we performed immunohistochemical analysis and 3-dimensional (3D) whole tumor imaging using light sheet fluorescence microscopy of IDF-imaged tissue sites. In all metastases, microvasculature was present but the angioarchitecture was chaotic and the vessel density and perfusion of vessels was significantly lower than in unaffected peritoneum. Immunohistochemical analysis showed expression of vascular endothelial growth factor and hypoxia inducible factor 1α, and 3D imaging demonstrated vascular continuity between metastases and the vascular network of the peritoneum beneath the elastic lamina of the peritoneum. We conclude that perfusion of the microvasculature within metastases is limited, which may cause hypoxia, affect the behavior of EOC metastases on the peritoneum and limit the response of EOC metastases to systemic treatment.
Farming Intensification and Environmental Justice in Northern Ireland
Authors: Gladkova Ekaterina 
Published: February 2020

AbstractGoing for Growth, an industry-led strategy to expand the agri-food sector, was adopted by the Northern Irish government in 2013 in order to encourage farming intensification in Northern Ireland. This approach, however, threatens an already fragile natural environment and has already had detrimental consequences for human health and well-being. This article employs an environmental justice perspective to scrutinize farming intensification in a community affected by this phenomenon. Based on findings from semi-structured interviews with local residents, the article describes their exposure to environmental risks as a result of farming intensification. The uneven distribution of environmental burdens is also coupled with limited opportunities for the local residents to engage in environmental decision-making and to be recognized as active agents of change. The article concludes that farming intensification in Northern Ireland is marked by procedural environmental injustice and should be addressed by downscaling levels of production and reforming decision-making processes.
Between-habitat distributions of pond tadpoles and their insect predators in response to fish presence
Authors: Kloskowski Janusz , Nieoczym Marek , Stryjecki Robert 
Published: February 2020

AbstractBetween-habitat distributions of prey shared by multiple predators depend on habitat use by the predators, whose own distributions may interact. We used a large-scale, whole-system natural experiment to examine distributions of anuran tadpoles and insect predators between pond microhabitats with contrasting complexity (open water vs emergent littoral vegetation) in drainable ponds that were either kept fishless or stocked with fish. Total relative densities of insect predators did not significantly differ with respect to the fish status of the ponds. Individual anuran taxa responded variously, but only fish-tolerantBufo bufodensities were higher in the presence of fish. The densities of both insect predators and tadpoles showed positive interactions between fish presence and the use of complex littoral habitat. The habitat shift to littoral vegetation could be indirectly amplified by fish adverse impact on submerged macrophytes, the main structured microhabitat in open-water areas. Irrespective of mechanisms of fish effects (direct consumption, behavioral deterrence or alteration of habitat conditions), aggregation of both tadpoles and insect predators in littoral vegetation may put tadpoles at greater risk of predation by insects, a potentially important factor of amphibian mortality in waters containing fish.
Searches for Light Dark Matter with the CRESST-III Experiment
Authors:   The CRESST Collaboration, Mancuso M. , Abdelhameed A. H. , Angloher G. , Breier R. , Bauer P. , Bento A. , Bertoldo E. , Bucci C. , Canonica L. , D’Addabbo A. , Di Lorenzo S. , Erb A. , von Feilitzsch F. , Ferreiro Iachellini N. , Fichtinger S. , Fuss A. , Gorla P. , Hauff D. , Jes̆kovský M. , Jochum J. , Kaizer J. , Kinast A. , Kluck H. , Kraus H. , Langenkämper A. , Mokina V. , Mondragon E. , Olmi M. , Ortmann T. , Pagliarone C. , Palus̆ová V. , Pattavina L. , Petricca F. , Potzel W. , Povinec P. , Pröbst F. , Reindl F. , Rothe J. , Schäffner K. , Schieck J. , Schipperges V. , Schmiedmayer D. , Schönert S. , Schwertner C. , Stahlberg M. , Stodolsky L. , Strandhagen C. , Strauss R. , Türkoğlu C. , Usherov I. , Willers M. , Zema V. , Zeman J. 
Published: February 2020

AbstractCryogenic Rare Event Search with Superconducting Thermometers (CRESST) is a long-standing direct dark matter detection experiment with cryogenic detectors located at the underground facility Laboratori Nazionali del Gran Sasso in Italy. CRESST-III, the third generation of CRESST, was specifically designed to have a world-leading sensitivity for low-mass dark matter (DM) (less than 2 GeV/$$\hbox {c}^{2}$$c2) to probe the spin-independent DM-nucleus cross section. At present, a large part of the parameter space for spin-independent scattering off nuclei remains untested for dark matter particles with masses below few GeV/$$\hbox {c}^{2}$$c2 although many motivated theoretical models having been proposed. The CRESST-III experiment employs scintillating $$\hbox {CaWO}_{{4}}$$CaWO4 crystals of $$\sim$$∼ 25 g as target material for dark matter interactions operated as cryogenic scintillating calorimeters at $$\sim$$∼ 10 mK. CRESST-III first data taking was successfully completed in 2018, achieving an unprecedented energy threshold for nuclear recoils. This result extended the present sensitivity to DM particles as light as $$\sim$$∼ 160 MeV/$$\hbox {c}^{2}$$c2. In this paper, an overview of the CRESST-III detectors and results will be presented.
The Ethics of AI Ethics: An Evaluation of Guidelines
Authors: Hagendorff Thilo 
Published: February 2020

AbstractCurrent advances in research, development and application of artificial intelligence (AI) systems have yielded a far-reaching discourse on AI ethics. In consequence, a number of ethics guidelines have been released in recent years. These guidelines comprise normative principles and recommendations aimed to harness the “disruptive” potentials of new AI technologies. Designed as a semi-systematic evaluation, this paper analyzes and compares 22 guidelines, highlighting overlaps but also omissions. As a result, I give a detailed overview of the field of AI ethics. Finally, I also examine to what extent the respective ethical principles and values are implemented in the practice of research, development and application of AI systems—and how the effectiveness in the demands of AI ethics can be improved.
The Factor Structure of Cognitive Functioning in Cognitively Healthy Participants: a Meta-Analysis and Meta-Analysis of Individual Participant Data
Authors:   ANDI Consortium, Agelink van Rentergem Joost A. , de Vent Nathalie R. , Schmand Ben A. , Murre Jaap M. J. , Staaks Janneke P. C. , Huizenga Hilde M. 
Published: February 2020

AbstractMany neuropsychologists are of the opinion that the multitude of cognitive tests may be grouped into a much smaller number of cognitive domains. However, there is little consensus on how many domains exist, what these domains are, nor on which cognitive tests belong to which domain. This incertitude can be solved by factor analysis, provided that the analysis includes a broad range of cognitive tests that have been administered to a very large number of people. In this article, two such factor analyses were performed, each combining multiple studies. However, because it was not possible to obtain complete multivariate data on more than the most common test variables in the field, not all possible domains were examined here. The first analysis was a factor meta-analysis of correlation matrices combining data of 60,398 healthy participants from 52 studies. Several models from the literature were fitted, of which a version based on the Cattell-Horn-Carroll (CHC) model was found to describe the correlations better than the others. The second analysis was a factor analysis of the Advanced Neuropsychological Diagnostics Infrastructure (ANDI) database, combining scores of 11,881 participants from 54 Dutch and Belgian studies not included in the first meta-analysis. Again, the model fit was better for the CHC model than for other models. Therefore, we conclude that the CHC model best characterizes both cognitive domains and which test belongs to each domain. Therefore, although originally developed in the intelligence literature, the CHC model deserves more attention in neuropsychology.
On the probability amplitude of quantum entanglement and the Pauli matrices
Authors: Duarte F. J. , Taylor T. S. , Slaten J. C. 
Published: February 2020

AbstractThe probability amplitudes for quantum entanglement, also known as Bell sates, are utilized to arrive explicitly at the identity matrix I and the $$\sigma_{x}$$σx, $$\sigma_{y}$$σy, and $$\sigma_{z}$$σz Pauli matrices, via a straight-forward $$2 \times 2$$2×2 matrix representation that utilizes the vector direct product. It is also indicated that this approach is completely equivalent to the utilization of the Kronecker product $$\otimes$$⊗ to multiply the relevant ket vectors. Furthermore, it is shown that the polarization rotation matrix R, operating on the various versions of the probability amplitude for quantum entanglement, yields four identities elegantly interconnecting these probability amplitudes.
Comparison of different surface disinfection treatments of drinking water facilities from a corrosion and environmental perspective
Authors: Romanovski Valentin , Claesson Per Martin , Hedberg Yolanda Susanne 
Published: February 2020

AbstractSurface disinfection of water facilities such as water wells requires measures that can remove pathogens from the walls to ensure a high drinking water quality, but many of these measures might increase corrosion of the contact surfaces (often highly pure steel) and affect the environment negatively due to disinfectant-contaminated waste sludge and wastewater. Today, most treatments worldwide are based on hypochlorites. We investigated the extent of corrosion during treatments of steel at relevant conditions of ozone, sodium, and calcium hypochlorite for drinking water preparation, utilizing weight loss, electrochemical, solution analytical, and surface analytical methods. The ozone treatment caused significantly less corrosion as compared with sodium or calcium hypochlorite with 150–250 mg/L active chlorine. Hypochlorite or other chlorine-containing compounds were trapped in corrosion products after the surface disinfection treatment with hypochlorite, and this risked influencing subsequent corrosion after the surface disinfection treatment. A life cycle impact assessment suggested ozone treatment to have the lowest negative effects on human health, ecosystems, and resources. Calcium hypochlorite showed the highest negative environmental impact due to its production phase. Our study suggests that ozone surface disinfection treatments are preferable as compared with hypochlorite treatments from corrosion, economic, and environmental perspectives.
Comparative neuropharmacological studies on three pyrrolidine-containing synthetic cathinones
Authors: Wojcieszak Jakub , Andrzejczak Dariusz , Wojtas Adam , Gołembiowska Krystyna , Zawilska Jolanta B. 
Published: February 2020

Abstract
Purpose
3,4-Methylenedioxypyrovalerone (3,4-MDPV) is a prevalent member of α-pyrrolidinophenones, a group of new psychoactive substances, known for its strong psychostimulant effect resulting from potent stimulation of dopamine (DA) circuitry in the brain. As 3,4-MDPV and its derivatives are successively being scheduled, each year novel analogs appear on the market. This study aimed at examination and direct comparison of psychostimulant properties of structural isomer of 3,4-MDPV, namely 2,3-MDPV along with a model α-pyrrolidinophenone, pyrovalerone.

Methods
Open field spontaneous locomotor activity of mice was assessed as a measure of psychostimulant potency. To evaluate the in vivo pharmacological properties of the drugs, extracellular levels of DA and serotonin (5-HT) in the mouse striatum were measured using an in vivo microdialysis technique followed by high-performance liquid chromatography with electrochemical detection. Involvement of dopaminergic system in the behavioral effects of the tested α-pyrrolidinophenones was examined by pre-treatment with a selective D1-DA receptor antagonist, SCH 23390, before measurement of locomotor activity in response to the drugs.

Results
3,4-MDPV, 2,3-MDPV and pyrovalerone produced time- and dose-dependent stimulation of locomotor activity, with 3,4-MDPV being more potent than the other two compounds. Observed locomotor stimulation was mediated by elevated DA-ergic neurotransmission, as all compounds caused a significant increase of extracellular DA levels in the striatum, with 3,4-MDPV being the most potent, and psychostimulant effects were abolished by SCH 23390. Interestingly, the tested pyrovalerones caused in vivo elevation of extracellular 5-HT levels, which contrasted with their in vitro pharmacologic properties.

Conclusions
Pyrovalerone, 2,3-MDPV and 3,4-MDPV produced psychostimulant effects mediated by stimulation of dopaminergic neurotransmission. Additionally, all tested compounds elevated extracellular levels of 5-HT in vivo.
Correction to: Automated measurement of bone scan index from a whole-body bone scintigram
Authors: Shimizu Akinobu , Wakabayashi Hayato , Kanamori Takumi , Saito Atsushi , Nishikawa Kazuhiro , Daisaki Hiromitsu , Higashiyama Shigeaki , Kawabe Joji 
Published: February 2020

The article Automated measurement of bone scan index from a whole-body bone scintigram
Autoantibodies against P29ING4 are associated with complex regional pain syndrome
Authors: Baerlecken N. T. , Gaulke R. , Pursche N. , Witte T. , Karst M , Bernateck M. 
Published: February 2020

Abstract
Introduction
Complex regional pain syndrome (CRPS) is a complication following trauma or surgery and may be difficult to diagnose since biomarkers are lacking. Using protein array technology, we found antibodies binding to p29ING4, which we further characterized using ELISA.

Methods
Thirty-six sera of early-stage type 1 CRPS, 66 sera of rheumatoid arthritis (RA), 53 sera of axial spondyloarthritis (axSpA), 29 sera of psoriatic arthritis (PsA), 22 sera of patients after radial fractures (trauma control), and 100 sera of blood donors (BD) were analyzed for anti-p29ING4. We established ELISAs with 7 different antigens and using different secondary antibodies binding to IgG, IgG1, IgG2, IgG3, IgG4, IgA, and IgM, and 2 different tests to detect immune complexes (IC) of p29ING4 and IgG or IgG1.

Results
The highest likelihood ratios versus CRPS and trauma control were observed considering the A1-23 (sensitivity 19%, specificity 100%, LR > 19) using IgG as a secondary antibody, the A120-165 (sensitivity 17%, specificity 100%, LR = 17) using IgG as a secondary antibody and the A120-165 (sensitivity 31%, specificity 95%, LR = 6.2) using IgA as a secondary antibody. IC of p29ING4 and IgG were present in 11/36 (31%) CRPS sera, 17/64 (27%) RA sera, 13/53 (25%) SpA sera, 5/29 (17%) PsA sera, 1/22 (5%) trauma control sera, and 4/100 (4%) sera of BD. IC of p29ING4 and IgG1 were present in 14/36 (39%) CRPS sera, 19/64 (30%) RA sera, 13/53 (25%) SpA, 1/29 (3%) PsA, 2/22 (9%) trauma control, and 4/100 (4%) of the BD sera.

Conclusion
Due to the lack of other biomarkers of type 1 CRPS, P29ING4 autoantibodies could be helpful in its diagnostic work-up.
Is Automation Appropriate? Semi-autonomous Telepresence Architecture Focusing on Voluntary and Involuntary Movements
Authors: Osawa Masahiko , Okuoka Kohei , Takimoto Yusuke , Imai Michita 
Published: February 2020

AbstractThis research aims to clarify the type of autonomous movements appropriate for telepresence robots. The design of telepresence robots’ autonomous movements should take into account both local and remote users. From the perspective of local users, we need autonomous movements that enhance a social telepresence in order to smooth remote communication. On the other hand, from the perspective of remote users, autonomous movements should be considered not only to reduce the operation load but also to address the danger of causing discomfort. However, in previous studies on automation, the criteria about which type of movements should be automated has remained unsettled. In this paper, we focused on voluntary and intentional movements as a classification type of movements that can be the criteria. Voluntary movements are intentional movements, whereas involuntary movements are movements without intention. To verify the effect of the automation of these movements, we developed a semi-autonomous telepresence robot that automates voluntary and involuntary movements. Then, we evaluated the impressions from local and remote users by conducting two experiments from each perspective. As a result, when not used in excess, local users evaluated both voluntary and involuntary autonomous movements positively, while it was suggested that automation of voluntary movements for remote users should be implemented with care.
Characterization of unburned carbon separated from power plant slag
Authors: Wierzchowski K. , Białecka B. , Calus Moszko J. , Klupa A. 
Published: February 2020

AbstractThis article presents the results of slag property studies, for characterization of unburned carbon separated. Size composition and loss-on-ignition distribution as a function of particle size were studied. The density analyses were performed for the selected size fractions. The successful tests on carbon particle separation using: the magnetic separation, separation in heavy liquids with magnetic separation of light ends and separation in a rising water stream with magnetic separation of the overflow methods, were performed. At laboratory scale and with using similarly rising water stream with magnetic separation methods, concentrates with 71–85% loss-on-ignition were obtained. Using gravitational separation method and magnetic separation, concentrates with 57–86.5% loss-on-ignition were obtained.
Quantitative trait loci mapping for resistance to maize streak virus in F2:3 population of tropical maize
Authors: Garcia-Oliveira A. L. , Menkir A. , Kumar P. Lava , Azuh V. , Jacob O. O. , Gedil M. 
Published: February 2020

AbstractMaize streak virus (MSV) continues to be a major biotic constraint for maize production throughout Africa. Concerning the quantitative nature of inheritance of resistance to MSV disease (MSVD), we sought to identify new loci for MSV resistance in maize using F2:3 population. The mapping population was artificially inoculated with viruliferous leafhoppers under screenhouse and evaluated for MSVD resistance. Using 948 DArT markers, we identified 18 quantitative trait loci (QTLs) associated with different components of MSVD resistance accounting for 3.1–21.4% of the phenotypic variance, suggesting that a total of eleven genomic regions covering chromosomes 1, 2, 3, 4, 5 and 7 are probably required for MSVD resistance. Two new genomic regions on chromosome 4 revealed the occurrence of co-localized QTLs for different parameters associated with MSVD resistance. Moreover, the consistent appearance of QTL on chromosome 7 for MSVD resistance is illustrating the need for fine-mapping of this locus. In conclusion, these QTLs could provide additional source for breeders to develop MSV resistance.
A universal pipeline for mobile mRNA detection and insights into heterografting advantages under chilling stress
Authors: Wang Ying , Wang Lingping , Xing Nailin , Wu Xiaohua , Wu Xinyi , Wang Baogen , Lu Zhongfu , Xu Pei , Tao Ye , Li Guojing , Wang Yuhong 
Published: February 2020

AbstractHeterografting has long been used to enhance the chilling tolerance of temperature-sensitive crops, including watermelon, whose mechanism is known to involve bidirectional long-distance mRNA movements. Despite several studies reporting on mobile mRNA (mb-mRNA) profiles in plants, accurate identification of mb-mRNAs is challenging owing to an array of technical problems. Here, we developed a bioinformatical pipeline that took most of the known technical concerns into consideration and is considered to be a universal tool for mb-mRNA detection in heterografts. By applying this pipeline to a commercial watermelon–bottle gourd heterografting system, we detected 130 and 1144 mb-mRNAs upwardly and 167 and 1051 mb-mRNAs downwardly transmitted under normal and chilling-stress conditions, respectively. Quantitative real-time PCR indicated a high accuracy rate (88.2%) of mb-mRNA prediction with our pipeline. We further revealed that the mobility of mRNAs was not associated with their abundance. Functional annotation and classification implied that scions may convey the stress signal to the rootstock, subsequently triggering energy metabolism reprogramming and abscisic acid-mediated stress responses by upward movement of effective mRNAs, ultimately leading to enhanced chilling tolerance. This study provides a universal tool for mb-mRNA detection in plant heterografting systems and novel insights into heterografting advantages under chilling stress.