bluuebunny/crossref_metadata_2025_split huggingface dataset:
A verifiable and privacy‐preserving multidimensional data aggregation scheme in mobile crowdsensing
Authors: Jiang Yun , Zhao Bowen , Tang Shaohua , Wu Hao‐Tian 
Published: June 2020

AbstractMobile crowdsensing has become a popular data collection paradigm and has been extensively studied. Since the analysis of sensory data usually reveals privacy of mobile users, data aggregation technology is widely used to avoid privacy disclosure. However, traditional privacy‐preserving data aggregation schemes cannot provide aggregate statistics of multidimensional data in fine‐grained areas or resist collusive attacks. Moreover, the cloud platform is not fully trusted, and it is challenging to verify the correctness of data aggregation results. To provide privacy‐preserving multidimensional statistics within fine‐grained areas and verify results of data aggregation, we propose a verifiable privacy‐preserving data aggregation scheme in this article, which is based on data double‐masking, Shamir's secret sharing, and bilinear mapping. Specifically, a key agreement is utilized to establish mask seeds for users, while the users are required to extend mask values and generate the verification key with bilinear mapping. The cloud platform aggregates masked data and provides proof of computational results. Theoretical analysis demonstrates our scheme can protect data and location privacy, verify the aggregation results, and improve the rubustness to failure. The simulation results show that the computational overhead of mobile devices by using the proposed anticollusion scheme is better than that of homomorphic encryption. In addition, the computational complexity of task requesters is less than that of the PVPA scheme for verification of multidimensional aggregation results.
Comparing spatio‐temporal distribution of the most common human parasitic infections in Iran over two periods 2007 to 2012 and 2013 to 2018: A systematic quantitative literature review
Authors: Kiani Behzad , Raouf Rahmati Amene , Bergquist Robert , Moghaddas Elham 
Published: June 2020

SummaryThis study analyses the spatio‐temporal trend of the prevalence of the four most prevalent parasitic diseases in Iran over two periods, 2007 to 2012 and 2013 to 2018, indicating high‐risk and low‐risk areas. Out of 19 126 articles, we selected 220 articles for data extraction and calculated the pooled prevalence for cutaneous leishmaniasis, human toxoplasmosis, giardiasis and blastocystosis for all 31 provinces in the country. Anselin local Moran's I was used to identify clusters and outliers in the prevalence rates. The mean prevalence of cutaneous leishmaniasis patients was found 35.12 per 100 000 in 2007 to 2012 but fell to 19.12 per 100 000 in the 2013 to 2018 period. The mean prevalence of acute and chronic toxoplasmosis was 2.36% and 32.5%, respectively, in 2007 to 2012, which changed to 2.28% and 31.14% in 2013 to 2018. The total prevalence of giardiasis declined from 9.8% in 2007 to 2012 to 4.8% in 2013 to 2018, while the mean prevalence of blastocystosis declined from 8.9% in 2007 to 2012 to 6.76% in the 2013 to 2018 period. There was only one high‐high cluster in 2007 to 2012 and that was due to giardiasis, while there were two in 2013 to 2018, one for blastocystosis and one for chronic toxoplasmosis. The total prevalence of blastocystosis, giardiasis and cutaneous leishmaniasis in Iran has continually declined since 2007. In contrast, the prevalence of toxoplasmosis in pregnant Iranian women has not been changed. Iran's Midwest has more parasitic infections compared to the Mideast, which may be explained by the existence of vast deserts and consequently dry and hot climate in the latter part of the country.
Allergic symptoms and sensitisation in adolescents with cows' milk allergy and atopic eczema in infancy
Authors: Piippo Sonja , Viljanen Mirva , Savilahti Erkki , Kuitunen Mikael 
Published: June 2020

AbstractBackgroundThe association between atopic sensitisation, atopic eczema (AE) and asthma is known, but distinct roles of allergies on long‐term health are unestablished.ObjectiveEvaluation of allergic symptoms and sensitisation in adolescents who in infancy had AE and verified cows' milk allergy (CMA) or AE and a negative CMA challenge, and controls.MethodsChildren with AE, with and without CMA, from a randomised controlled study in 1999‐2001 examining the effect of probiotics on AE severity at older than 12 months of age, attended a follow‐up visit at age 16 to 18, with age‐matched controls. Data came from a questionnaire (ISAAC questionnaire), analysis of serum antigen‐specific immunoglobulin Es (IgEs), and clinical evaluation. Group comparisons were carried out (χ2 tests and logistic regression).ResultsFifty‐two patients with AE and CMA (AE/CMA+ group), 52 with AE and suspicion of CMA (AE/CMA− group), and 57 controls attended a study visit. IgE‐mediated sensitisation was significantly more prevalent in the AE/CMA+ group vs the controls, for horse, cat, dog, egg white and wheat (P < .024 for all). For birch, timothy and mugwort (P < .008 for all), sensitisation was more prevalent in both the AE/CMA+ group and the AE/CMA− group vs controls. On the basis of questionnaire data the AE/CMA + group reported a significantly higher lifetime prevalence of wheezing (64% vs 35% and 32%; P = .001), noninfectious rhinitis (85% vs 62% and 56%; P = .004), and hay fever (77% vs 52% and 33%; P < .001) vs the AE/CMA− group and the control group, respectively.Conclusion and Clinical RelevancePatients with AE and CMA in infancy, as opposed to patients with AE only, or controls, report more allergic symptoms and exhibit more allergic sensitisation in adolescence. This indicates that CMA in infancy is an independent risk factor of allergic disease in adolescence.
Effect of riser height on rotation uniformity and application rate of the dynamic fluidic sprinkler
Authors: Fordjour Alexander , Zhu Xingye , Jiang Chenlong , Liu Junping 
Published: June 2020

AbstractThe objective of this paper was to investigate the effect of riser heights on rotation uniformity and application rate of the newly designed dynamic fluidic sprinkler. The dynamic fluidic sprinkler was tested using different nozzle sizes of 5 and 6 mm. The sprinkler head was mounted on 1.3, 1.5, 1.7 and 1.9 m risers at 90° in the horizontal direction and was placed about 0.9 m above the top of the cans. The following operating pressures were tested: 150 and 200 kPa. A program was written to simulate the non‐uniform of rotation of the nozzle during the full circle‐spraying process. It was found that the riser height had a significant effect on application rate and uniformity. The comparison of standard deviation with different risers showed that differences in standard deviation were much lower for the 1.9 m riser height. The deviation was in the range of 0.14 ~ 0.26, 0.14 ~ 0.42, 0.18 ~ 0.50 and 0.13 ~ 0.69 mm h−1 considering the riser heights of 1.9, 1.7, 1.5 and 1.3 m. For all the nozzle sizes, a smaller standard deviation was recorded under 150 kPa. The deviation range was 0.15 ~ 0.24, 0.17 ~ 0.45, 0.18 ~ 0.45 and 0.2 ~ 0.66 mm h−1 for 1.9, 1.7, 1.5 and 1.3 m, respectively. With respect to nozzle sizes, 5 mm gave better standard deviations and the deviation range was from 0.14 ~ 0.26, 0.15 ~ 0.45, 0.2 ~ 0.7 and 0.23 ~ 0.74 mm h−1 with radial heights of 1.9, 1.7, 1.5 and 1.3 m, respectively. The range of the coefficient of uniformity values for overlapped quadrants for the 5 mm nozzle was as follows: 78% at a spacing of 10 to 72% at 80% overlapped spacing. The highest occurred at 50% spacing and increased with an overlapped spacing of 10 to 50%, ranging from 78 to 87% with an average of 82.5%. © 2020 John Wiley & Sons, Ltd.
The effects of 28‐day early‐life exposure to triphenyl phosphate (TPhP) on odor preference and sexual behavior in female rats
Authors: Nakayama Airi , Hattori Tatsuya , Isobe Anna , Kobayashi Shohei , Suzuki Go , Takigami Hidetaka , Kawaguchi Maiko 
Published: June 2020

AbstractMany chemical substances are detectable in house dust, and they are consequently taken into our bodies via the mouth and nose. Triphenyl phosphate (TPhP), a flame retardant that has an estrogen‐like effect in vitro, is present in house dust at high concentrations. Estrogen exposure during development has significant influences on reproductive behavior in rodents, and its effects persist until maturity. In the present study, we investigated the effect of early life exposure to TPhP on the reproductive behavior of female rats. Oral treatment with TPhP (25 or 250 mg/kg), ethinyl estradiol (EE; 15 μg/kg) as a positive control, or sesame oil as a negative control, were given to female rats (from birth to 28 days of age). The 8‐week‐old rats were bilaterally ovariectomized. At 12–15 weeks of age, the rats were subjected to odor preference and sexual behavior tests. In the odor preference test, the oil group showed significantly higher preference for male odor than female odor, but the low‐dose TPhP treatment group lost the preference for male odor, indicating a possible outcome of early life TPhP exposure on sexual recognition. In the sexual behavior test, both the EE and TPhP treatment groups displayed significantly less proceptive behavior. These results suggest that early life exposure to TPhP disturbs the normal sexual behavior of female rats.
Neurogenic Heterotopic Ossifications Develop Independently of Granulocyte Colony-Stimulating Factor and Neutrophils
Authors: Tseng Hsu-Wen , Kulina Irina , Salga Marjorie , Fleming Whitney , Vaquette Cedryck , Genêt François , Levesque Jean-Pierre , Alexander Kylie A 
Published: June 2020

ABSTRACT
Neurogenic heterotopic ossifications (NHOs) are incapacitating heterotopic bones in periarticular muscles that frequently develop following traumatic brain or spinal cord injuries (SCI). Using our unique model of SCI-induced NHO, we have previously established that mononucleated phagocytes infiltrating injured muscles are required to trigger NHO via the persistent release of the pro-inflammatory cytokine oncostatin M (OSM). Because neutrophils are also a major source of OSM, we investigated whether neutrophils also play a role in NHO development after SCI. We now show that surgery transiently increased granulocyte colony-stimulating factor (G-CSF) levels in blood of operated mice, and that G-CSF receptor mRNA is expressed in the hamstrings of mice developing NHO. However, mice defective for the G-CSF receptor gene Csf3r, which are neutropenic, have unaltered NHO development after SCI compared to C57BL/6 control mice. Because the administration of recombinant human G-CSF (rhG-CSF) has been trialed after SCI to increase neuroprotection and neuronal regeneration and has been shown to suppress osteoblast function at the endosteum of skeletal bones in human and mice, we investigated the impact of a 7-day rhG-CSF treatment on NHO development. rhG-CSF treatment significantly increased neutrophils in the blood, bone marrow, and injured muscles. However, there was no change in NHO development compared to saline-treated controls. Overall, our results establish that unlike monocytes/macrophages, neutrophils are dispensable for NHO development following SCI, and rhG-CSF treatment post-SCI does not impact NHO development. Therefore, G-CSF treatment to promote neuroregeneration is unlikely to adversely promote or affect NHO development in SCI patients. © 2020 American Society for Bone and Mineral Research.
Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM
Authors: Wen Quan , Jing Junjun , Han Xia , Feng Jifan , Yuan Yuan , Ma Yuanyuan , Chen Shuo , Ho Thach-Vu , Chai Yang 
Published: June 2020

ABSTRACTProgenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well-established model for investigating the molecular and cellular mechanisms that regulate organogenesis. Despite advances in our understanding of how tooth crown formation is regulated, we have limited understanding of tooth root development. Runt-related transcription factor 2 (RUNX2) is a well-known transcription factor in osteogenic differentiation and early tooth development. However, the function of RUNX2 during tooth root formation remains unknown. We revealed in this study that RUNX2 is expressed in a subpopulation of GLI1+ root progenitor cells, and that loss of Runx2 in these GLI1+ progenitor cells and their progeny results in root developmental defects. Our results provide in vivo evidence that Runx2 plays a crucial role in tooth root development and in regulating the differentiation of root progenitor cells. Furthermore, we identified that Gli1, Pcp4, NOTUM, and Sfrp2 are downstream targets of Runx2 by integrating bulk and single-cell RNA sequencing analyses. Specifically, ablation of Runx2 results in downregulation of WNT inhibitor NOTUM and upregulation of canonical WNT signaling in the odontoblastic site, which disturbs normal odontoblastic differentiation. Significantly, exogenous NOTUM partially rescues the impaired root development in Runx2 mutant molars. Collectively, our studies elucidate how Runx2 achieves functional specificity in regulating the development of diverse organs and yields new insights into the network that regulates tooth root development. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
MORPHEUS: An automated tool for unbiased and reproducible cell morphometry
Authors: Ruffinatti Federico Alessandro , Genova Tullio , Mussano Federico , Munaron Luca 
Published: June 2020

AbstractHere we present a new Fiji/ImageJ2 plugin called Multiparametric Morphometric Analysis of EUcaryotic cellS (MORPHEUS), designed for the automated evaluation of cell morphometry from images acquired by fluorescence microscopy. MORPHEUS works with sampling distributions to learn—in an unsupervised manner and by a nonparametric approach—how to recognize the cells suitable for subsequent analysis. Afterward, the algorithm performs the evaluation of the most relevant cell‐shape descriptors over the full set of detected cells. Optionally, also the extraction of nucleus features and a double‐scale analysis of orientation can be performed. The whole algorithm is implemented as a one‐click procedure, thus minimizing the user's intervention. By reducing biases and errors of human origin, MORPHEUS is intended to be a useful tool to enhance reproducibility in the bioimage analysis.
Identification of potential technologies for 1,4‐Butanediol production using prospecting methodology
Authors: Silva Ramon Geraldo Campos , Ferreira Tatiana Felix , Borges Élcio Ribeiro 
Published: June 2020

Abstract1,4‐Butanediol (1,4‐BDO) is a four‐carbon diol used for industrial applications such as organic solvents, and the production of adhesives, fibers and polyurethanes. 1,4‐BDO currently is produced through several petrochemical routes: hydrogenation of maleic anhydride, isomerization of propylene oxide, acetoxylation of butadiene, and the reaction between formaldehyde and acetylene. The current trends in 1,4‐BDO production involve the utilization of renewable sources such as biomass. In this context, the present study aimed to identify promising technologies of 1,4‐BDO production through prospecting methodology based on the analyses of patents and scientific article, describing the most relevant aspects of those emerging technologies. An increasing amount of 1,4‐BDO production focused on biotechnological routes has been reported, with the US heavily involved in the development of new technologies. This study tracked three promising technologies which have potential for application in a biorefinery context because those processes involve (i) production of 1,4‐BDO from sugars, classified herein as the biotechnological route; (ii) production of intermediates from sugar fermentation followed by catalytic conversion into 1,4‐BDO, classified herein as the hybrid route, and (iii) furan/furfural conversion into 1,4‐BDO. © 2020 Society of Chemical Industry
Deletion of 2‐aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1
Authors: Leandro João , Dodatko Tetyana , DeVita Robert J. , Chen Hongjie , Stauffer Brandon , Yu Chunli , Houten Sander M. 
Published: June 2020

AbstractGlutaric aciduria type 1 (GA1) is an inborn error of lysine degradation characterized by acute encephalopathy that is caused by toxic accumulation of lysine degradation intermediates. We investigated the efficacy of substrate reduction through inhibition of 2‐aminoadipic semialdehyde synthase (AASS), an enzyme upstream of the defective glutaryl‐CoA dehydrogenase (GCDH), in a cell line and mouse model of GA1. We show that loss of AASS function in GCDH‐deficient HEK‐293 cells leads to an approximately fivefold reduction in the established GA1 clinical biomarker glutarylcarnitine. In the GA1 mouse model, deletion of Aass leads to a 4.3‐, 3.8‐, and 3.2‐fold decrease in the glutaric acid levels in urine, brain, and liver, respectively. Parallel decreases were observed in urine and brain 3‐hydroxyglutaric acid levels, and plasma, urine, and brain glutarylcarnitine levels. These in vivo data demonstrate that the saccharopine pathway is the main source of glutaric acid production in the brain and periphery of a mouse model for GA1, and support the notion that pharmacological inhibition of AASS may represent an attractive strategy to treat GA1.
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases
Authors: Jiang Dengrong , Lin Zixuan , Liu Peiying , Sur Sandeepa , Xu Cuimei , Hazel Kaisha , Pottanat George , Darrow Jacqueline , Pillai Jay J. , Yasar Sevil , Rosenberg Paul , Moghekar Abhay , Albert Marilyn , Lu Hanzhang 
Published: June 2020

BackgroundAlzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, there exists a considerable overlap in their clinical manifestations, and most biomarkers reveal similar abnormalities between these two conditions.PurposeTo evaluate the potential of cerebral oxygen extraction fraction (OEF) as a biomarker for differential diagnosis of Alzheimer's disease and VCI. We hypothesized that in Alzheimer's disease OEF will be reduced (decreased oxygen consumption due to decreased neural activity), while in vascular diseases OEF will be elevated (increased oxygen extraction due to abnormally decreased blood flow).Study TypeProspective cross‐sectional.PopulationSixty‐five subjects aged 52–89 years, including 33 mild cognitive impairment (MCI), 7 dementia, and 25 cognitively normal subjects.Field Strength/Sequence3T T2‐relaxation‐under‐spin‐tagging (TRUST) and fluid‐attenuated inversion recovery imaging (FLAIR).AssessmentOEF, consensus diagnoses of cognitive impairment, vascular risk factors (such as hypertension, hypercholesterolemia, diabetes, smoking, and obesity), cognitive assessments, and cerebrospinal fluid concentration of amyloid and tau were assessed.Statistical TestsMultiple linear regression analyses of OEF with diagnostic category (normal, MCI, or dementia), vascular risks, cognitive performance, amyloid and tau pathology.ResultsWhen evaluating the entire group, OEF was found to be lower with more severe cognitive impairment (β = −2.70 ± 1.15, T = −2.34, P = 0.02), but was higher with greater vascular risk factors (β = 1.36 ± 0.55, T = 2.48, P = 0.02). Further investigation of the subgroup of participants with low vascular risks (N = 44) revealed that lower OEF was associated with worse cognitive performance (β = 0.04 ± 0.01, T = 3.27, P = 0.002) and greater amyloid burden (β = 92.12 ± 41.23, T = 2.23, P = 0.03). Among cognitively impaired individuals (N = 40), higher OEF was associated with greater vascular risk factors (β = 2.19 ± 0.71, T = 3.08, P = 0.004).Data ConclusionThese findings suggest that OEF is differentially affected by Alzheimer's disease and VCI pathology and may be useful in etiology‐based diagnosis of cognitive impairment.Level of Evidence1Technical EfficacyStage 3 J. MAGN. RESON. IMAGING 2020;52:1829–1837.
Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China
Authors: Ji Tianxing , Liu Ying , Li Yaqing , Khan Shahzad Akbar , Zhou Qiang , Chen Bo , Lin Zhen , Wang Xingchen , Ye Xianmiao , Zheng Xuehua , Chen Ling , Feng Liqiang 
Published: June 2020

AbstractThe molecular prevalence of human adenoviruses (HAdVs) in Datong city and molecular evolution of HAdV‐C species is still obscure. Here, we explored the molecular prevalence of HAdVs by simultaneous sequencing of hexon and fiber. Then, the penton gene fragments of HAdV‐C species were determined by sequencing. Finally, genomic and proteotyping analysis were performed for exploration of molecular evolution of unique HAdV‐6. Our results showed that dominant molecular types of HAdVs were HAdV‐3, HAdV‐2, and HAdV‐1 based on the hexon and fiber genotype. Among H2F2 isolates, P1H2F2 was most common, followed by P2H2F2 and HAdV‐89. The clinical symptoms of HAdV‐1 or HAdV‐2 infected patients were more severe than HAdV‐3 infected patients, the prognosis of HAdV‐1, HAdV‐2, and HAdV‐3 infected patients was indifference. Genomic and proteotyping analysis demonstrated that DT15 was different from HAdV‐6 prototype, with high‐discrepant sequences localized in the E3 region. In conclusion, HAdV‐1 and HAdV‐2 have a high affinity to infect younger children and cause more severe symptoms than HAdV‐3. The E3 gene of HAdV‐C species was considered as highly recombination and mutation region.
An assessment of early 20th century Antarctic pressure reconstructions using historical observations
Authors: Fogt Ryan L. , Belak Connor P. , Jones Julie M. , Slivinski Laura C. , Compo Gilbert P. 
Published: June 2020

AbstractWhile gridded seasonal pressure reconstructions poleward of 60°S extending back to 1905 have been recently completed, their skill has not been assessed prior to 1958. To provide a more thorough evaluation of the skill and performance in the early 20th century, these reconstructions are compared to other gridded datasets, historical data from early Antarctic expeditions, ship records, and temporary bases. Overall, the comparison confirms that the reconstruction uncertainty of 2–4 hPa (evaluated after 1979) over the Southern Ocean is a valid estimate of the reconstruction error in the early 20th century. Over the interior and near the coast of Antarctica, direct comparisons with historical data are challenged by elevation‐based reductions to sea level pressure. In a few cases, a simple linear adjustment of the reconstruction to sea level matches the historical data well, but in other cases, the differences remain greater than 10 hPa. Despite these large errors, comparisons with continuous multi‐season observations demonstrate that aspects of the interannual variability are often still captured, suggesting that the reconstructions have skill representing variations on this timescale, even if it is difficult to determine how well they capture the mean pressure at these higher elevations. Additional comparisons with various 20th‐century reanalysis products demonstrate the value of assimilating the historical observations in these datasets, which acts to substantially reduce the reanalysis ensemble spread, and bring the reanalysis ensemble mean within the reconstruction and observational uncertainty.