bluuebunny/crossref_metadata_2025_split huggingface dataset:
Private life telepressure and workplace cognitive failure among hospital nurses: The moderating role of mobile phone presence
Authors: Cambier Ruben , Van Laethem Michelle , Vlerick Peter 
Published: August 2020

AbstractAimTo examine whether the presence of a mobile phone has a moderating role in the relationship between nurses’ private life telepressure and workplace cognitive failure.DesignCross‐sectional quantitative study using self‐report questionnaires.MethodsData were collected between December 2019 – January 2020. In total, 849 Registered Nurses from three Belgian hospitals completed the online survey. Data were analysed with hierarchical regression analyses and simple slope tests.ResultsOverall, the positive relationship between private life telepressure and workplace cognitive failure was moderated by mobile phone presence. Specifically, the experience of private life telepressure did only relate to higher workplace cognitive failure when nurses kept their mobile phone nearby (i.e. in their pockets). Additional exploratory analyses revealed that this moderation effect only held among nurses in young adulthood and regardless of the notification settings of their mobile phone.ConclusionsThe present findings indicate the unintended risk of mobile phone presence at work as it relates to higher workplace cognitive failure in nurses who experience private life telepressure. Ensuring there are clear organizational policies and practises in place to store away personal belongings of healthcare personnel during work hours would therefore seem beneficial for hospitals.ImpactConsidering the increased presence of mobile phones nowadays, a more detailed understanding is necessary on how these devices might distract personnel in a healthcare setting. The present study gives further insight into this topic and shows that in particular nurses in young adulthood who experience telepressure towards personal messages report more cognitive failure when their personal mobile phones are present, even when they do not actually use these devices. This furnishes additional evidence in support of hospitals' formal policy to forbid personal mobile phones of healthcare personnel when at work.
Patients´ experiences of pain in the intensive care – The delicate balance of control
Authors: Hylén Mia , Akerman Eva , Idvall Ewa , Alm‐Roijer Carin 
Published: August 2020

AbstractAimTo explore the patients´ experiences of pain when being cared for in the intensive care.DesignAn exploratory, qualitative design was chosen.MethodInterviews were performed with patients (October 2015–March 2017) within a week of post‐intensive care (N = 16). Thematic analysis was used as method for analysis.ResultsThe findings generated two themes – a lack of control and to struggle for control. Pain was described as overwhelming, both in body and mind and generating the experience of a lack of control, with feelings of incapacitation, isolation, and having their needs unmet. Feeling in control of the pain and thus in control of the situation was experienced as a constant struggle. Well‐planned care, finding ways to handle the pain and good communication were all helpful in this struggle.ConclusionThe participants recalled their experience of pain in the ICU and control seems to be crucial for how pain is experienced. They experienced a lack of control due to not only the pain but also the treatment, which can be avoided by the nurse continuously evaluating and individualising the care. Balanced care, meeting the patients’ needs and good communication helps the patient feel more in control when experiencing pain.ImpactThe experience of pain is dependent on control for the intensive care patient. The nurse may help them gain control and thereby handle the experience of pain through including the patient, striving for better communication and implementing individualised care that continuously assesses and treats pain.
Reproducibility and repeatability of identifying the latest electrical activation during mapping of coronary sinus branches in CRT recipients
Authors: Kronborg Mads B. , Stephansen Charlotte , Kristensen Jens , Gerdes Christian , Nielsen Jens C. 
Published: August 2020

AbstractIntroductionStudies have shown an association between the outcome in cardiac resynchronization therapy (CRT) and longer interventricular delay at the site of the left ventricular (LV) lead. Targeted LV lead placement at the latest electrically activated segment increases LV function further as compared with standard treatment. We aimed to determine reproducibility and repeatability of identifying the latest electrically activated segment during mapping of all available coronary sinus (CS) branches in patients receiving CRT.MethodsWe included 35 patients who underwent CRT implantation with protocolled mapping guided LV lead implantation aiming for the site of the latest electrical activation. Three different doctors experienced in electrophysiology and implantation of CRT devices independently measured time interval from the local bipolar right ventricular (RV) electrogram (EGM) to the local unipolar LV EGM at all mapped sites (RV–LV). The segment with the latest electrical activation was defined as the target segment (TS) and the CS tributary containing TS was defined as the target vein (TV). Weighted κ statistics with 95% confidence intervals were computed to assess intra‐ and interobserver agreement for TS and TV.ResultsWe mapped 258 segments within 131 veins. Weighted κ values for repeatability were 0.85 (0.81–0.89) for TS and 0.92 (0.89–0.93) for TV, and weighted κ values of interobserver agreement ranged from 0.70 (0.61–0.73) to 0.80 (0.76–0.83) for TS and 0.73 (0.64–0.78) to 0.86 (0.83–0.89) for TV among all three observers.ConclusionThe reproducibility and repeatability of identifying the latest electrically activated segment during mapping of all available CS branches in patients receiving CRT range from good to very good.
Systematic review of BRAF/MEK inhibitors‐induced Severe Cutaneous Adverse Reactions (SCARs)
Authors: Torres‐Navarro I. , de Unamuno‐Bustos B. , Botella‐Estrada R. 
Published: August 2020

AbstractSevere cutaneous adverse reactions (SCARs) [Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed eruption (GBFE)] are severe drug reactions that often require hospitalization and could be fatal. BRAF and MEK inhibitors (BRAF/MEKi) are a standard of care in patients with BRAF‐mutated metastatic melanomas. These agents are administered until disease progression or unacceptable toxicity occurs. This review has focus on BRAF/MEKi‐induced SCARs. A systematic search of the following terms: ‘vemurafenib’, ‘cobimetinib’, ‘dabrafenib’, ‘trametinib’, ‘encorafenib’, ‘binimetinib’, ‘Acute Generalized Exanthematous Pustulosis’, ‘Stevens Johnson syndrome’, ‘Toxic Epidermal Necrolysis’, ‘Generalized Bullous Fixed Eruption’ ‘Drug Hypersensitivity Syndrome’, and ‘DRESS’ in simple combination (every drug with each disease) and all in combination, was performed on MEDLINE, EMBASE, Web of Knowledge and The Cochrane Library repositories, with no restriction on language, for original studies. One hundred sixty‐eight original articles were found, 26 (retrospective series, case reports and conference abstracts) were selected, and 21 were included in the qualitative synthesis. A total of 31 SCAR cases (23 DRESS and 8 SJS/TEN – 1 SJS and 7 TEN –) were identified. Vemurafenib was the culprit drug in all but one case, which was dabrafenib‐induced. Mean time to SCAR onset from drug intake was 15.5 and 11.4 days, for SJS/TEN and DRESS, respectively. For the DRESS cases, hepatic involvement occurred in 96% and renal alterations in 87% of patients. Overall, BRAF/MEKi‐induced SCARs are rare. Among them, vemurafenib is the drug that requires more close monitoring for SCARs. Prior immunotherapy can favour SCARs. Vemurafenib DRESS is likely to occur within the first fifteen days of treatment accompanied by hepatic and renal involvement. Following vemurafenib‐induced SCAR resolution, switching to dabrafenib seems to be a safe alternative for these patients’ treatment.
Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study
Authors: Hassan Haidar , Quinlan Daniel J. , Ghanem Ali 
Published: August 2020

AbstractBackgroundAutologous platelet‐derived preparations have been used in many surgical fields to improve healing outcomes, with benefits reported in several aesthetic indications.AimsThis single‐center, prospective, uncontrolled study evaluated the efficacy of injectable platelet‐rich fibrin (i‐PRF) for facial skin rejuvenation using an objective skin analysis system and validated patient‐reported outcome measures.Patients/MethodsPRF® PROCESS system technology was used to prepare i‐PRP. Eleven healthy female individuals were included in the study and over 3‐months received monthly intradermal injections of i‐PRF in 3 facial regions: malar areas (1 mL each side), nasolabial fold (0.5 mL each side), and upper lip skin above the vermilion border (1 mL). The efficacy of the procedures was assessed by objective skin analysis (VISIA®) and a subjective patient‐reported outcome (FACE‐Q) assessment at baseline and after 3 months.ResultsA significant improvement in skin surface spots (P = .01) and pores (P = .03) was seen at 3‐months follow‐up. Other variables, such as skin texture, wrinkles, ultraviolet spots, and porphyrins, showed a numerical improvement. FACE‐Q scales that measure satisfaction with appearance all showed a significant improvement from baseline, including satisfaction with skin (P = .002), satisfaction with facial appearance (P = .025), satisfaction with cheeks (P = .001), satisfaction with lower face and jawline (P = .002), and satisfaction with lips (P = .04). No major adverse effects were reported.ConclusionsA series of three i‐PRF injections resulted in significant rejuvenation of the face skin at 3‐month follow‐up, as shown by improved skin analysis parameters and patient self‐assessment scores.
Qualitative descriptions of patient perceptions about fall risks, prevention strategies and self‐identity: Analysis of fall prevention Motivational Interviewing conversations
Authors: Kiyoshi‐Teo Hiroko , Northrup‐Snyder Kathlynn , Robert Davis Mary , Garcia Ellen , Leatherwood Amy , (Seiko) Izumi Shigeko 
Published: August 2020

AbstractBackgroundOlder adults are often reluctant to engage in fall prevention activities.ObjectivesTo understand how older adults respond to fall prevention and identify attributes that affect their responses to fall prevention.MethodsQualitative content analysis of Fall Prevention Motivational Interviewing conversations that were conducted as an intervention for a fall prevention study in the USA. We report the methods, results and discussions using the COnsolidated criteria for REporting Qualitative research checklist.ResultsConversations from 30 participants were analysed. Participants showed various responses to fall prevention from acceptance and engagement to ambivalence to denial or giving up. Three attributes affecting how they responded to fall prevention were as follows: (a) their perception of fall risks, (b) their perception about fall prevention strategies and (c) self‐identity. If participants perceived that their fall risks were temporary or modifiable, they were more likely to engage in fall prevention. If participants perceived that their fall risks were permanent or unmodifiable, they seemed to have difficulty accepting fall risks or gave up engaging in fall prevention strategies. Participants were more willing to adopt fall prevention strategies that involved minor adjustments but expressed more resistance to adopting strategies that required major adjustments. Further, their response to accepting or not accepting fall prevention was influenced by their perception of whether the fall risks and fall prevention strategies aligned with their self‐identity.ConclusionFindings underscore the importance of understanding older adults’ self‐identify and perceptions about fall prevention.Relevance to clinical practiceExploring older adults’ self‐identity and perceptions about fall prevention can be useful to support their engagement in fall prevention.
Coordination between lingual motion and pressure production during dipper/tipper type swallows
Authors: Shitara Satoko , Fujiwara Shigehiro , Okawa Jumpei , Kodama Shohei , Hori Kazuhiro , Ono Takahiro 
Published: August 2020

AbstractBackgroundTongue motor biomechanics during swallowing was not fully elucidated due to the technical difficulty.ObjectiveTo evaluate the relationship between tongue motion and tongue pressure production by simultaneously measuring tongue motion and tongue pressure during water swallowing.MethodsIn 12 healthy male participants (mean age, 30.8 ± 4.2 years), tongue pressure and tongue motion trajectory during dipper‐ and tipper‐type swallows of 3 mL of water were measured using a sensor sheet system equipped with five sensing points and an electromagnetic articulography, respectively. The temporal correlation between motion of anterior/posterior tongue and tongue pressure production during swallowing was evaluated on the synchronised waveforms.ResultsIn the dipper‐type swallow, a similar up‐and‐down motion pattern in vertical direction was observed among all participants before tongue pressure production. Those motion patterns were common at the anterior and posterior tongue locations with a temporal difference in some segment of tongue motion. On the other hand, tongue directly attached to hard palate with temporal synchronicity between the anterior and posterior parts. In both types of swallow, a strong temporal correlation was found between the timing of tongue‐palate contact and the Onset of tongue pressure by intra‐class correlation coefficients.ConclusionFrom the simultaneous measurement of tongue motion and tongue pressure production, the tongue motion pattern during water swallowing and the temporal correlation between tongue motion and tongue pressure production were elucidated.
Equilibrium opacity in ultimatum‐offer bargaining
Authors: Konrad Kai A. , Thum Marcel 
Published: August 2020

AbstractWe consider ultimatum bargaining between a seller and a buyer of an asset. They know each other's valuation of the asset. Both can defer their decisions to delegates. These delegates have opaque preferences. Seller and buyer choose the opacity of their delegate. For the seller's delegate this choice is restricted to a random reservation price drawn from the set of symmetric two‐point distributions around the seller's true reservation price. The opacity choice of the buyer's delegate is restricted to a random willingness‐to‐pay drawn from the set of symmetric two‐point distribution around the buyer's true willingness‐to‐pay. We characterize the set of pure‐strategy equilibria in their delegation choices. Multiple equilibria arise. Except for two corner solutions, both players will exploit the strategy of opacity. A large set of efficient equilibria exist. For these, opacity choices do not reduce the probability of transacting, but benefit the buyer compared with the no‐delegation equilibrium. We also study the robustness of the results with respect to the player's ability to also resort to a tougher delegate in addition to the opacity choice.
Cardiac autonomic control during non‐REM and REM sleep stages in paediatric patients with Prader‐Willi syndrome
Authors: Brito Leandro C. , Queiroga Thereza , Franco Ruth R. , Passone Caroline G. B. , Lopes Maria‐Cecilia , Shea Steven A. , Bueno Clarissa , Soster Leticia M. S. F. A. 
Published: August 2020

AbstractCardiac death is the second most prevalent cause in Prader‐Willi syndrome (PWS). Paediatric patients with PWS often present cardiac autonomic dysfunction during wakefulness, obesity and sleep‐disordered breathing. However, the extent of cardiac autonomic modulation during sleep in PWS has not been documented. The objective of this study was to assess alterations in cardiac autonomic modulation of paediatric patients with PWS during different sleep stages. Thirty‐nine participants in three groups: 14 PWS, 13 sex and age‐matched lean controls (LG) and 12 obese‐matched controls (OB). All participants underwent overnight polysomnography, including continuous electrocardiogram recordings. Heart rate variability (HRV) was analysed during representative periods of each sleep stage through time and frequency domains calculated across 5‐min periods. Between‐within ANOVAs were employed (p < .05). The results show that total HRV was lower in PWS than OB and LG during slow‐wave sleep (SWS) (standard deviation of all NN intervals [SDNN] ms, p = .006). Parasympathetic modulation assessed by time‐domain analysis was lower during SWS in PWS compared to both OB and LG (square root of the mean of the sum of the squares of differences between adjacent NN intervals [RMSSD] ms, p = .004; SDSD, standard deviation of differences between adjacent NN intervals [SDSD] ms, p = .02; number of adjacent NN intervals differing by >50 ms [NN50] ms, p = .03; proportion of adjacent NN intervals differing by >50 ms [pNN50] ms, p = .01). Sympathovagal balance assessed by frequency‐domain analysis was lower during both N2 and SWS than during the rapid eye movement (REM) sleep stage, but not different among groups. In conclusion, this group of paediatric patients with PWS had impaired cardiac autonomic balance due to reduced parasympathetic modulation during SWS. This result could imply an underlying increased cardiovascular risk in PWS even during early age and independent of obesity.
Systematic decrease of slow‐wave sleep after a guided imagery designed to deepen sleep in low hypnotizable subjects
Authors: Cordi Maren Jasmin , Rasch Björn 
Published: August 2020

AbstractSlow‐wave sleep is one of the most important restorative components of sleep and central for our health and cognitive functioning. Although the amount of slow‐wave sleep depends on sleep drive, age and other factors, also the pre‐sleep mental state might influence sleep depth. We had shown that a pre‐sleep hypnotic suggestion to sleep more deeply increased slow‐wave sleep duration in hypnotizable subjects. In contrast, low‐hypnotizable participants decreased sleep depth after this intervention. A possible reason might be an aversion to and active resistance against hypnosis. To overcome this potential opposition, we introduced the procedure as ‘guided imagery’. We replaced the hypnotic induction by a breathing relaxation. Importantly, the suggestion ‘to sleep more deeply’ remained identical. We expected that these changes would make it easier for low‐hypnotizable subjects to benefit from the suggestion. In contrast, young healthy low‐hypnotizable participants did not show positive effects. Similar to our previous studies, they exhibited a reduced slow‐wave sleep duration after the intervention. Additionally, the ratio between slow‐wave activity and beta band power decreased. Subjective sleep quality remained unaffected. Our results indicate that suggestions to sleep more deeply result in decreased sleep depth in low‐hypnotizable participants regardless of the mental technique (guided imagery versus hypnosis). Thus, the aversion against hypnosis per se cannot explain the detrimental effect of the intervention on slow‐wave sleep in low‐hypnotizable subjects. The results support the notion that our mental state before sleep can influence subsequent slow‐wave sleep. However, the mechanisms of the contradictory decrease in low‐hypnotizable subjects remain unknown.
Characterization of hepatitis E virus natural infection in farmed rabbits
Authors: Li Shuangshuang , Li Manyu , He Qiyu , Liang Zhaochao , Shu Jingyi , Wang Lin , Wang Ling 
Published: August 2020

AbstractRabbit hepatitis E virus (HEV3‐ra) is widely distributed in rabbits worldwide and several recent reports found that HEV3‐ra can infect humans. Therefore, people exposed to rabbits are at high risk of HEV infection. This study was conducted to investigate the characteristics and outcomes of HEV3‐ra natural infection in rabbits. Seventy farmed rabbits (3‐month‐old) were surveyed in a farm in Beijing, China. Rabbits tested positive for HEV RNA were followed weekly for testing of HEV RNA, antigen, antibody and alanine aminotransferase (ALT) level. Liver and kidney tissue was collected for histopathology. Complete genome sequencing of the isolated HEV3‐ra strain was performed (CHN‐BJ‐r4, GenBank: MT364355). The infectivity of CHN‐BJ‐r4 was tested in ten naïve rabbits by intravenous injection or gavage. Anti‐HEV antibody and HEV RNA were tested positive in 7.14% (5/70) and 11.4% (8/70) of rabbits, respectively. Eight naturally infected rabbits were followed, and 37.5% (3/8) of the observed rabbits were found to have fecal shedding of HEV ranging from 3‐22 weeks with high viral load (105‐107 copies/g). Two out of eight rabbits showed temporary viremia. Naturally infected rabbits presented elevated ALT level, seroconversion, and liver histopathology. Complete genome of HEV3‐ra isolated in this study shared 84.61%‐94.36% nucleotide identity with known HEV3‐ra complete genomes. The isolated HEV3‐ra strain was infectious and could infect other rabbits through intravenous and fecal–oral route. Naturally infected rabbits showed up to 22‐week fecal virus shedding with high viral load. These features increased the risk of rabbit‐to‐rabbit and rabbit‐to‐human transmission.
Suppression of wheat blast resistance by an effector of Pyricularia oryzae is counteracted by a host specificity resistance gene in wheat
Authors: Inoue Yoshihiro , Vy Trinh Thi Phuoug , Tani Daichi , Tosa Yukio 
Published: August 2020

Summary

Wheat blast caused by the Triticum pathotype of Pyricularia oryzae poses a serious threat to wheat production in South America and Asia and is now becoming a pandemic disease. Here, we show that Rmg8, a promising wheat gene for resistance breeding, is suppressed by PWT4, an effector gene of P. oryzae, and in turn that the suppression is counteracted by Rwt4, a wheat gene recognizing PWT4.

When PWT4 was introduced into a wheat blast isolate carrying AVR‐Rmg8 (an avirulence gene corresponding to Rmg8), PWT4 suppressed wheat resistance conferred by Rmg8. PWT4 did not alter the expression of AVR‐Rmg8, but higher expression of PWT4 led to more efficient suppression. This suppression was observed in rwt4 carriers, but not in Rwt4 carriers, indicating that it is counteracted by Rwt4.

PWT4 was assumed to have been horizontally transferred from a weed‐associated cryptic species, P. pennisetigena, to an Avena isolate of P. oryzae in Brazil. This implies a potential risk of the acquisition of PWT4 by the wheat blast fungus and the ‘breakdown’ of Rmg8.

We suggest that Rmg8 should be introduced together with Rwt4 into a wheat cultivar when it is used for resistance breeding.