bluuebunny/crossref_metadata_2025_split huggingface dataset:
Favorable therapeutic response after anti-Mesothelin antibody–drug conjugate treatment requires high expression of Mesothelin in tumor cells
Authors: Lazzerini Lea , Jöhrens Korinna , Sehouli Jalid , Cichon Günter 
Published: August 2020

Abstract
Purpose
The cell surface glycoprotein Mesothelin is overexpressed in ovarian, fallopian tube, endometrial, cervical and primary peritoneal cancer and, therefore, might become a particular interesting tumor target in gynecologic oncology. However, even in malignant tumors of the same entity the level of Mesothelin expression varies between individuals, hence it can be expected that the response to Mesothelin-targeting therapies will be variable as well. In this study we explored the therapeutic potency of a novel anti-Mesothelin antibody–drug conjugate (Anetumab ravtansine) as a function of Mesothelin expression in the targeted tumor cells.

Methods
Anti-tumor activity studies were performed in human uterine xenograft tumor models that express Mesothelin at high, moderate or low levels. The antibody–drug conjugate (ADC) was applied in varying doses ranging from 2 to 15 mg/kg at variable intervals in tumor bearing SCID/beige mice and the impact on tumor growth was monitored.

Results
The therapeutic response to the anti-Mesothelin ADC correlated closely with the level of Mesothelin expression in tumor cells. Within the applied dose levels complete tumor regression was achieved only in tumors which expressed Mesothelin at particularly high levels (Hela cell tumors). The application of high anti-Mesothelin ADC doses less frequently was more efficious than giving lower doses at a higher frequency.

Conclusion
The studies confirm the great therapeutic potential of Anetumab ravtansine. However, a favorable treatment outcome requires strong Mesothelin expression in tumor cells. Future clinical trials may benefit from a more rigorous selection of appropriate patients based on the level of Mesothelin expression in their tumor tissue. If, in addition, it is possible to better control side effects by introducing protective measures and by doing so to increase the maximum tolerated dose, Anetumab ravtansine has the potency to become a valuable therapeutic tool, especially in the field of gynecological oncology.
Laparoscopic complete mesocolic excision with true central vascular ligation for right-sided colon cancer
Authors: Enomoto Masanobu , Katsumata Kenji , Kasahara Kenta , Tago Tomoya , Okazaki Naoto , Wada Takahiro , Kuwabara Hiroshi , Mazaki Junichi , Ishizaki Tetsuo , Nagakawa Yuichi , Tsuchida Akihiko 
Published: August 2020

Abstract
Background
Complete mesocolic excision (CME) is known to be effective for colon cancer. However, in right-sided colon cancer, central vascular ligation (CVL) is not easy to perform. In particular, in patients in whom the superior mesenteric vein (SMV) runs on the ventral side of the superior mesenteric artery (SMA) (Type V/A), laparoscopic ligation of the artery at its root is extremely difficult compared with this procedure in patients in whom the SMA runs on the ventral side of the SMV (Type A/V).

Methods
We started performing laparoscopic CME with true CVL for right-sided colon cancer using the SMA as a landmark in 2015, and by 2019, we had completed it for 60 patients. To start, the mesocolon is opened well to the caudal side of the ileocolic vessels. The mesentery is then fully detached from the retroperitoneal tissue, after which the ileocolic vessels are ligated at their roots. D3 lymph node dissection of the lymph nodes around the SMA and SMV on the resection side is also performed using the SMA as a landmark, and depending on the location of the tumor, the roots of the right and middle colic vessels are ligated and divided. This study was conducted with the approval of the Tokyo Medical University Ethics Committee. All patients provided informed consent.

Results
The tumor was located in the cecum in 21 cases, the ascending colon in 33, and the transverse colon in 6. The mean operating time was 229 min and the mean volume of hemorrhage was 67 ml. There was one Clavien-Dindo Grade 3 or worse postoperative complication (ileus). There were no surgery-related or in-hospital deaths.

Conclusion
This procedure can be performed comparatively safely. However, since it requires some skill, we consider that it should only be performed in suitable cases by teams with sufficient experience.
Reliability, validity and responsiveness of the Dutch version of the AOSpine PROST (Patient Reported Outcome Spine Trauma)
Authors: Sadiqi Said , Post Marcel W. , Hosman Allard J. , Dvorak Marcel F. , Chapman Jens R. , Benneker Lorin M. , Kandziora Frank , Rajasekaran S. , Schnake Klaus J. , Vaccaro Alexander R. , Oner F. Cumhur 
Published: August 2020

Abstract
Purpose
To validate the Dutch version of AOSpine PROST (Patient Reported Outcome Spine Trauma).

Methods
Patients were recruited from two level-1 trauma centers from the Netherlands. Next to the AOSpine PROST, patients also filled out SF-36 for concurrent validity. Descriptive statistics were used to analyze the characteristics. Content validity was assessed by evaluating the number of inapplicable or missing questions. Also floor and ceiling effects were analyzed. Internal consistency was assessed by calculating Cronbach’s α and item-total correlation coefficients (itcc). Spearman correlation tests were performed within AOSpine PROST items and in correlation with SF-36. Test–retest reliability was analyzed using Intraclass Correlation Coefficients (ICC). Responsiveness was assessed by calculating effect sizes (ES) and standardized response mean (SRM). Factor analysis was performed to explore any dimensions within AOSpine PROST.

Results
Out of 179 enrolled patients, 163 (91.1%) were included. Good results were obtained for content validity. No floor or ceiling effects were seen. Internal consistency was excellent (Cronbach’s α = 0.96, itcc 0.50–0.86), with also good Spearman correlations (0.25–0.79). Compared to SF-36, the strongest correlation was seen for physical functioning (0.79; p < .001). Also test–retest reliability was excellent (ICC = 0.92). Concerning responsiveness analysis, very good results were seen with ES = 1.81 and SRM = 2.03 (p < 0.001). Factor analysis revealed two possible dimensions (Eigenvalues > 1), explaining 65.4% of variance.

Conclusions
Very satisfactory results were obtained for reliability, validity and responsiveness of the Dutch version of AOSpine PROST. Treating surgeons are encouraged to use this novel and validated tool in clinical setting and research to contribute to evidence-based and patient-centered care.
Levodopa improves handwriting and instrumental tasks in previously treated patients with Parkinson’s disease
Authors: Müller Thomas , Harati Ali 
Published: August 2020

AbstractMotor symptoms in patients with Parkinson’s disease may be determined with instrumental tests and rating procedures. Their outcomes reflect the functioning and the impairment of the individual patient when patients are tested off and on dopamine substituting drugs. Objectives were to investigate whether the execution speed of a handwriting task, instrumentally assessed fine motor behavior, and rating scores improve after soluble levodopa application. 38 right-handed patients were taken off their regular drug therapy for at least 12 h before scoring, handwriting, and performance of instrumental devices before and 1 h after 100 mg levodopa intake. The outcomes of all performed procedures improved. The easy-to-perform handwriting task and the instrumental tests demand for fast and precise execution of movement sequences with considerable cognitive load in the domains' attention and concentration. These investigations may serve as additional tools for the testing of the dopaminergic response.
“We Ought to Eat in Order to Work, Not Vice Versa”: MacIntyre, Practices, and the Best Work for Humankind
Authors: Sinnicks Matthew 
Published: August 2020

AbstractThis paper draws a distinction between ‘right MacIntyreans’ who are relatively optimistic that MacIntyre’s vision of ethics can be realised in capitalist society, and ‘left MacIntyreans’ who are sceptical about this possibility, and aims to show that the ‘left MacIntyrean’ position is a promising perspective available to business ethicists. It does so by arguing for a distinction between ‘community-focused’ practices and ‘excellence-focused’ practices. The latter concept fulfils the promise of practices to provide us with an understanding of the best work for humankind and highlights the affinities between MacIntyre’s concept of a practice and Marx’s conception of good work as free, creative activity. The paper concludes with a suggestion that we reflect on the best forms of work so that we can strive to ensure the very best activities, those most consonant with our flourishing, one day become available to all.
Fiscal devaluation and relative prices: evidence from the Euro area
Authors: Arachi Giampaolo , Assisi Debora 
Published: August 2020

AbstractThe theoretical literature has long recognized that a fiscal devaluation, brought about by a budget-neutral shift from social security contributions towards value added tax (V-FD), could improve price competitiveness and help restore trade imbalances, especially for countries that cannot devaluate their currency. This paper provides evidence on the effects of a fiscal devaluation on the real effective exchange rate, the terms of trade and net exports. We focus on countries that joined the Euro Area in 1999 for which fiscal devaluation is a salient issue. We find that the responses are highly heterogeneous across countries and, on average, the estimates provide only a weak support to the theoretical predictions that a fiscal devaluation could affect the real effective exchange rate and the terms of trade. Consistently, we also find negligible results on the trade balance. We conclude that the potential of a V-FD should not be overemphasized, since its effects are rather limited on both relative prices and quantities.
Technical considerations when using the EEG export of the SEDLine Root device
Authors: von Dincklage Falk , Jurth Carlo , Schneider Gerhard , S García Paul , Kreuzer Matthias 
Published: August 2020

AbstractElectroencephalographic (EEG) patient monitoring during general anesthesia can help to assess the real-time neurophysiology of unconscious states. Some monitoring systems like the SEDLine Root allow export of the EEG to be used for retrospective analysis. We show that changes made to the SEDLine display during recording affected the recorded EEG. These changes can strongly impact retrospective analysis of EEG signals. Real-time changes of the feed speed in the SEDLine Root device display modifies the sampling rate of the exported EEG. We used a patient as well as a simulated EEG recording to highlight the effects of the display settings on the extracted EEG. Therefore, we changed EEG feed and amplitude resolution on the display in a systematic manner. To visualize the effects of these changes, we present raw EEG segments and the density spectral array of the recording. Changing the display’s amplitude resolution affects the amplitudes. If the amplitude resolution is too fine, the exported EEG contains clipped amplitudes. If the resolution is too coarse, the EEG resolution becomes too low leading to a low-quality signal making frequency analysis impossible. The proportion of clipped or zero-line data caused by the amplitude setting was > 60% in our sedated patient. Changing the display settings results in undocumented changes in EEG amplitude, sampling rate, and signal quality. The occult nature of these changes could make the analysis of data sets difficult if not invalid. We strongly suggest researchers adequately define and keep the EEG display settings to export good quality EEG and to ensure comparability among patients.
Comparison of common perioperative blood loss estimation techniques: a systematic review and meta-analysis
Authors: Gerdessen Lara , Meybohm Patrick , Choorapoikayil Suma , Herrmann Eva , Taeuber Isabel , Neef Vanessa , Raimann Florian J. , Zacharowski Kai , Piekarski Florian 
Published: August 2020

AbstractEstimating intraoperative blood loss is one of the daily challenges for clinicians. Despite the knowledge of the inaccuracy of visual estimation by anaesthetists and surgeons, this is still the mainstay to estimate surgical blood loss. This review aims at highlighting the strengths and weaknesses of currently used measurement methods. A systematic review of studies on estimation of blood loss was carried out. Studies were included investigating the accuracy of techniques for quantifying blood loss in vivo and in vitro. We excluded nonhuman trials and studies using only monitoring parameters to estimate blood loss. A meta-analysis was performed to evaluate systematic measurement errors of the different methods. Only studies that were compared with a validated reference e.g. Haemoglobin extraction assay were included. 90 studies met the inclusion criteria for systematic review and were analyzed. Six studies were included in the meta-analysis, as only these were conducted with a validated reference. The mixed effect meta-analysis showed the highest correlation to the reference for colorimetric methods (0.93 95% CI 0.91–0.96), followed by gravimetric (0.77 95% CI 0.61–0.93) and finally visual methods (0.61 95% CI 0.40–0.82). The bias for estimated blood loss (ml) was lowest for colorimetric methods (57.59 95% CI 23.88–91.3) compared to the reference, followed by gravimetric (326.36 95% CI 201.65–450.86) and visual methods (456.51 95% CI 395.19–517.83). Of the many studies included, only a few were compared with a validated reference. The majority of the studies chose known imprecise procedures as the method of comparison. Colorimetric methods offer the highest degree of accuracy in blood loss estimation. Systems that use colorimetric techniques have a significant advantage in the real-time assessment of blood loss.
Evaluation of crustal inhomogeneity parameters in the southern Longmenshan fault zone and adjacent regions
Authors: Fan Xiao-Ping , He Yi-Cheng , Yang Cong-Jie , Wang Jun-Fei 
Published: August 2020

AbstractBroadband teleseismic waveform data from 13 earthquakes recorded by 70 digital seismic stations were selected to evaluate the inhomogeneity parameters of the crustal medium in the southern Longmenshan fault zone and its adjacent regions using the teleseismic fluctuation wavefield method. Results show that a strong inhomogeneity exists beneath the study region, which can be divided into three blocks according to its structure and tectonic deformation features. These are known as the Sichuan-Qinghai Block, the Sichuan-Yunnan Block, and the Mid-Sichuan Block. The velocity fluctuation ratios of the three blocks are approximately 5.1%, 3.6%, and 5.1% in the upper crust and 5.1%, 3.8%, and 4.9% in the lower crust. The inhomogeneity correlation lengths of the three blocks are about 10.1 km, 14.0 km, and 10.7 km in the upper crust and 11.8 km, 17.0 km, and 11.8 km in the lower crust. The differences in the crustal medium inhomogeneity beneath the Sichuan-Yunnan Block, the Sichuan-Qinghai Block, and the Mid-Sichuan Block may be related to intensive tectonic movement and material flow in the crust and upper mantle.
Goth Music and Depressive Symptoms among Adolescents: A Longitudinal Study
Authors: ter Bogt Tom , Hale William W. , Canale Natale , Pastore Massimiliano , Vieno Alessio 
Published: August 2020

AbstractIdentification with Goth youth culture has been related to elevated levels of depression, self-harm and suicide ideation. However, this identification may be difficult to assess as Goth is stigmatized and adolescents may hesitate to self-identify. Conversely, adolescents readily respond to questions on their music preferences. This study addresses the potential link between liking Goth music and depressive symptoms in a four-year study among 10 to 15-year-olds (N = 940, M age = 12.4 at T1, 49% female). In this study, it was found that Goth music is only liked by a small minority of adolescents (4 to 11%). Both girls and boys who liked Goth music reported increased levels of depressive symptoms as they grew older. The findings of this study suggest that a preference for Goth music emerges as an early, sensitive marker of dormant or developing depressive symptoms in adolescents. The mechanisms through which music preferences can translate into or sustain depressive symptoms are discussed.
Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box
Authors: Chen Chun-Yen , Lin Pei-Hsuan , Chen Kun-Hung , Cheng Yi-Sheng 
Published: August 2020

AbstractThe phytohormone ethylene is widely involved in many developmental processes and is a crucial regulator of defense responses against biotic and abiotic stresses in plants. Ethylene-responsive element binding protein, a member of the APETALA2/ethylene response factor (AP2/ERF) superfamily, is a transcription factor that regulates stress-responsive genes by recognizing a specific cis-acting element of target DNA. A previous study showed only the NMR structure of the AP2/ERF domain of AtERF100 in complex with a GCC box DNA motif. In this report, we determined the crystal structure of AtERF96 in complex with a GCC box at atomic resolution. We analyzed the binding residues of the conserved AP2/ERF domain in the DNA recognition sequence. In addition to the AP2/ERF domain, an N-terminal α-helix of AtERF96 participates in DNA interaction in the flanking region. We also demonstrated the structure of AtERF96 EDLL motif, a unique conserved motif in the group IX of AP2/ERF family, might involve in the transactivation of defense-related genes. Our study establishes the structural basis of the AtERF96 transcription factor in complex with the GCC box, as well as the DNA binding mechanisms of the N-terminal α-helix and AP2/ERF domain.
Determinants of adoption and adoption intensity of precision agriculture technologies: evidence from South Dakota
Authors: Kolady Deepthi E. , Van der Sluis Evert , Uddin Md Mahi , Deutz Allen P. 
Published: August 2020

AbstractPrecision agriculture technologies (PATs) are promoted as part of both economically efficient and environmentally sustainable agriculture practices. Available PATs are generally classified into two groups; namely, embodied-knowledge and information-intensive PATs. Adoption levels of embodied-knowledge PATs are high relative to information-intensive PATs. Previous studies on the adoption of PATs do not differentiate between embodied-knowledge and information-intensive PATs. Additionally, most studies focus on the adoption of one or two of the available PATs rather than on adoption intensity—defined as the total number of individual PATs adopted. This study fills this gap in the literature by focusing on PAT adoption in general, and adoption intensity of embodied-knowledge and information-intensive PATs in particular. The study uses data from 198 farm-operator respondents in eastern South Dakota from a 2017 survey and employs descriptive statistics and probit and Poisson regression models for the analyses. As per the study, GPS guidance, yield monitor, and automatic section control systems are the most popular PATs, each with adoption rates of over 50%. Overall, findings from the study show that the effect of cropland size, producers’ perceptions of profitability, and operator off-farm income are similar for both adoption and adoption intensity of embodied-knowledge and information-intensive PATs. However, there are differences in the effect of land productivity and familiarity with computer use between adoption and adoption intensity and between embodied-knowledge and information-intensive PATs. The effect of producers’ perception of the environmental benefits of PATs is inconclusive and needs to be investigated in future research. The results indicate that analyzing PATs as a group of technologies masks differences in determinants between embodied-knowledge and information-intensive PATs. The study provides insights for developing programs, policies, and outreach efforts that encourage the adoption and adoption intensity of both embodied-knowledge and information-intensive PATs. Findings from the study will also be of interest to precision agriculture researchers, extension personnel, agribusinesses, and policymakers who may consider PATs as tools for improving agricultural sustainability and food security.
Socio-Economic Modernization and the “Crisis of Trust” in China: A Multi-level Analysis of General and Particular Trust
Authors: Steinhardt H. Christoph , Delhey Jan 
Published: August 2020

AbstractTheorists have long disagreed about the impact of socio-economic modernization on social trust. The pessimistic school asserts that modernization undermines the structural conditions for high levels of trust. The optimistic account argues that it delivers economic security and human empowerment and thereby enhances trust. Adapting these contrasting theories to the specific case of China, this article puts them to the test with survey data from the World Values Survey. Exploiting the condition of highly uneven levels of regional development, combined with common political institutions and a shared cultural heritage, the study conducts a multi-level analysis of survey data from over 1900 individuals and a wide range of regional statistics from 61 county-level units. While trust in family members and particular trust beyond the family are unaffected by levels of regional modernization, we find robust evidence to suggest that regional modernization is associated with substantially higher levels of general trust. The results further suggests that higher general trust in more developed regions does not lead to an enhanced conversion of particular into general trust. This indicates that general trust is nurtured through the contextual effect of residing in more modern social environments. Overall, these findings provide substantial support for modernization optimists and lend themselves to a reinterpretation of a widely discussed “trust crisis” in China, which to date is often interpreted according to the pessimistic view of modernization.
Seasonal dynamics of shoot biomass of dominant clonal herb species in an oak–hornbeam forest herb layer
Authors: Rawlik Mateusz , Jagodziński Andrzej M. 
Published: August 2020

AbstractSeasonal fluctuations of light availability, nutrient concentrations, and moisture affect plant population traits like density, standing biomass, and flowering. We analyzed seasonal changes of density and shoot biomass of the four most frequent herb species growing in an oak–hornbeam forest community, i.e., Anemone nemorosa, Ficaria verna, Galeobdolon luteum, and Galium odoratum. In 2010 and 2011 plant biomass was harvested from 7 to 10 randomly situated square sample plots (0.36 m2) in the homogenous oak–hornbeam forest community every week in the spring and every two weeks in the summer and autumn. The highest abundance of Anemone nemorosa reached over 1000 shoots per m2, of Ficaria verna 459.5 shoots per m2, of Galium odoratum 83.6 shoots per m2, and of Galeobdolon luteum 98.4 shoots per m2 (means for 2010 and 2011, based on all sample plots). We did not observe negative correlation between density and shoot biomass. Growth rates of vegetative shoot biomass amounted to 0.857 mg day−1 for Anemone nemorosa, 0.467 mg day−1 for Ficaria verna, 0.722 mg day−1 for Galium odoratum, and 0.448 mg day−1 for Galeobdolon luteum (means for 2010 and 2011). Spring ephemerals had much higher densities of shoots than summer-greens. Summer-greens reached higher biomass of individual shoots than spring ephemerals. Flowering shoots constituted only 4, 2, and 11% of all shoots for A. nemorosa, F. verna, and G. odoratum, respectively. More resource availability resulting in high shoot biomass did not translate to higher share of flowering shoots.