bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrathin Single Crystalline MgO(111) Nanosheets**
Authors: Liu Pengxin , Abdala Paula Macarena , Goubert Guillaume , Willinger Marc‐Georg , Copéret Christophe 
Published: November 2020

AbstractSynthesizing high‐quality two‐dimensional nanomaterials of nonlayered metal oxide is a challenge, especially when long‐range single‐crystallinity and clean high‐energy surfaces are required. Reported here is the synthesis of single‐crystalline MgO(111) nanosheets by a two‐step process involving the formation of ultrathin Mg(OH)2nanosheets as a precursor, and their selective topotactic conversion upon heating under dynamic vacuum. The defect‐rich surface displays terminal ‐OH groups, three‐coordinated O2−sites and low‐coordinated Mg2+sites, as well as single electrons trapped at oxygen vacancies, which render the MgO nanosheets highly reactive, as evidenced by the activation of CO molecules at low temperatures and pressures with formation of strongly adsorbed red‐shifted CO and coupling of CO molecules into C2species.
Centrifugally spun mats based on biopolyesters/hydroxyapatite and their potential as bone scaffolds
Authors: Padilla‐Gainza Victoria M. , Rodríguez‐Tobías Heriberto , Morales Graciela , Saucedo‐Salazar Esmeralda , Lozano Karen , Montaño‐Machado Vanessa , Mantovani Diego 
Published: November 2020

AbstractThis work studied the potential of centrifugal spinning for the production of fibrous materials based on poly(D,L‐lactic acid) (PDLLA) and poly(3‐hydroxybutyrate) (PHB) with hydroxyapatite nanoparticles (n‐Hap). The influence of n‐Hap concentration (5, 10, and 15 wt.%) and spinneret angular speed on the final fiber morphology were analyzed. Further experimental evaluations were implemented to determine the effect of n‐Hap on the thermal and mechanical performance. The optimum parameters that show a balance among high yield production of homogeneous fibers with the smallest fiber average diameter were found to be at 5 wt.% of n‐Hap processed at 7000 rpm for PDLLA, and 5, 10, and 15 wt.% of n‐Hap at 6000 rpm for PHB. The thermal stability, for both systems, was not significantly affected. The mechanical performance of PHB systems was improved with the addition of n‐Hap. Osteoblast cell viability tests depicted a favorable cell response on the PDLLA systems.
Facile fabrication of highly conductive poly (styrene‐co‐methacrylic acid)/ poly(aniline) microspheres based on surface carboxylation modification
Authors: Cheng Haonan , Yin Yunjie , Wang Bo , Zhu Junrong , Wang Chaoxia 
Published: November 2020

AbstractFabrication of highly conductive poly(styrene)/poly(aniline) (PS/PANI) microspheres has been considerably explored. Improving the adsorption efficiency of aniline on the PS microspheres is still a challenge by facile methods. To overcome this problem, poly(styrene‐co‐methacylic acid) (poly(St‐co‐MAA)) is firstly synthesized for capturing anilinium ions, and then the in‐situ polymerization of aniline is implemented to obtain highly conductive poly(St‐co‐MAA)/PANI microspheres. The prepared poly(St‐co‐MAA) microspheres bearing an average particle size of 238 nm possess a low polymer dispersity index (PDI, 0.082) and high zeta‐potential, which guarantee no agglomeration and deposition of microspheres latex after 30 days at room temperature. After the in‐situ polymerization of aniline, the conductive disc based on poly(St‐co‐MAA)/PANI microspheres presents a superior electrical conductivity of 14.6 S m−1 at an inferior PANI loading of 5.74 vol% and a relatively low electrical percolation threshold (EPT < 0.16 vol%). The results indicate that the carboxylic microspheres for preparing high polymer/PANI microspheres is effective. Meanwhile, poly(St‐co‐MAA)/PANI microspheres show a great potential in manufacture of conductive composites due to their excellent electrical conductivity.
Can Dual‐Energy Computed Tomography Be Used to Identify Early Calcium Crystal Deposition in the Knees of Patients With Calcium Pyrophosphate Deposition?
Authors: Budzik Jean‐François , Marzin Claire , Legrand Julie , Norberciak Laurène , Becce Fabio , Pascart Tristan 
Published: November 2020

ObjectiveTo assess the ability of dual‐energy computed tomography (DECT) in identifying early calcium crystal deposition in menisci and articular cartilage of the knee, depending on the presence/absence of chondrocalcinosis seen on conventional CT.MethodsOne hundred thirty‐two knee DECT scans from patients with suspected crystal‐associated arthropathy were reviewed and assigned to a calcium pyrophosphate deposition (CPPD) group (n = 50) or a control group (n = 82). Five DECT attenuation parameters were measured in preset regions of interest (ROIs) in menisci and articular cartilage and compared between groups using linear mixed models with adjustment for confounders. Subgroup analysis, excluding ROIs with chondrocalcinosis seen on conventional CT, was performed.ResultsIn both menisci and articular cartilage, and for all 5 DECT attenuation parameters, calcified ROIs in CPPD patients showed significantly higher values than ROIs in controls (P ≤ 0.036). Conversely, noncalcified ROIs in CPPD patients were comparable with those in controls (P ≥ 0.09). While specific DECT parameters yielded good accuracy (area under the curve [AUC] 0.87–0.88) in differentiating calcified ROIs in CPPD patients from ROIs in controls, DECT failed to distinguish between noncalcified ROIs in CPPD patients and controls (AUC 0.58–0.59).ConclusionWhile DECT has the potential to characterize knee intraarticular mineralization, this technique cannot yet accurately identify early calcium crystal deposition that is not visible as chondrocalcinosis on conventional CT.
Recent Insights into Rate Performance Limitations of Li‐ion Batteries
Authors: Heubner Christian , Nikolowski Kristian , Reuber Sebastian , Schneider Michael , Wolter Mareike , Michaelis Alexander 
Published: November 2020

AbstractIncreasing the fast charging capabilities and the driving range of electric vehicles are major goals in Li‐ion battery research to accelerate mass market adoption and reduce greenhouse gas emissions. This requires a fundamental understanding of the performance limiting factors to enable a knowledge‐based optimization of materials, electrode design and cell architectures. Herein, electrochemical fundamentals and recent insights concerning rate performance limitations of Li‐ion batteries at the electrode level are reviewed and discussed from charge and mass transport perspectives. The application of straightforward analytical and semi‐empirical models is highlighted in view of understanding specific performance limiting factors of electrodes for Li‐ion batteries based on experimental investigations. The summarized insights are discussed regarding promising improvement strategies to approach the practical limits of liquid electrolyte‐based Li‐ion batteries.
Codelivery of survivin inhibitor and chemotherapeutics by tumor‐derived microparticles to reverse multidrug resistance in osteosarcoma
Authors: Wei Daiqing , Li Cui , Ye Junwu , Xiang Feifan , Xu Yangbo , Liu Juncai 
Published: November 2020

AbstractReportedly, the elevated expression of survivin has been observed in several tumor types, strictly involved in tumor development. In the present study, we detected elevated survivin expression in tumor tissues derived from patients with chemoresistant osteosarcoma when compared with those from chemosensitive patients. Importantly, knockdown of survivin in osteosarcoma cells significantly suppressed cell proliferation and chemoresistance both in vitro and in vivo. Simultaneously, chemotherapy mediates the upregulation of survivin in osteosarcoma cells through a survivin‐based selective killing effect, resulting in the development of multidrug resistance. The utilization of tumor‐derived microparticles to coencapsulate the survivin inhibitor YM155 and chemotherapeutic agents could effectively reverse multidrug resistance, leading to improved anticancer effects, as well as reduced systemic toxicity. In summary, the expression of survivin contributes to resistance toward osteosarcoma drugs, whereas employing survivin inhibiting combination therapy, based on a microparticle codelivery system, could efficiently reverse resistance and avoid potential systemic toxicity.
Light‐ and Manganese‐Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time‐Scale Revealed by Time‐Resolved Spectroscopic Analysis
Authors: Firth James D. , Hammarback L. Anders , Burden Thomas J. , Eastwood Jonathan B. , Donald James R. , Horbaczewskyj Chris S. , McRobie Matthew T. , Tramaseur Adam , Clark Ian P. , Towrie Michael , Robinson Alan , Krieger Jean‐Philippe , Lynam Jason M. , Fairlamb Ian J. S. 
Published: November 2020

AbstractManganese‐mediated borylation of aryl/heteroaryl diazonium salts emerges as a general and versatile synthetic methodology for the synthesis of the corresponding boronate esters. The reaction proved an ideal testing ground for delineating the Mn species responsible for the photochemical reaction processes, that is, involving either Mn radical or Mn cationic species, which is dependent on the presence of a suitably strong oxidant. Our findings are important for a plethora of processes employing Mn‐containing carbonyl species as initiators and/or catalysts, which have considerable potential in synthetic applications.
The Reactivity of Isomeric Nitrenium Lewis Acids with Phosphines, Carbenes, and Phosphide
Authors: Zhu Diya , Qu Zheng‐Wang , Zhou Jiliang , Stephan Douglas W. 
Published: November 2020

AbstractAlkylation of spiro[fluorene‐9,3’‐indazole] at N(1) and N(2) with tBuCl affords the nitrenium cations [C6H4N2(tBu)C(C12H8)][BF4], 1 and 2, respectively. Compound 1 converts to 2 over the temperature range 303–323 K with a free energy barrier of 28±5 kcal mol−1. Reaction of 1 with PMe3 afforded the N‐bound phosphine adduct [C6H4N(tBu)N(PMe3)C(C12H8)]BF4] 3. However, phosphines attack 2 at the para‐carbon atom of the aryl group with concurrent cleavage of N(2)−C(1) bond and proton migration to C(1) affording [(R3P)C6H3NN(tBu)CH(C12H8)][BF4] (R=Me 4, nBu 5). Analogous reactions of 1 and 2 with the carbene SIMes prompt attack at the para‐carbon with concurrent loss of H. affording the radical cation salts [(SIMes)C6H3N(tBu)NC(C12H8).][BF4] 6 and [(SIMes)C6H3NN(tBu)C(C12H8).][BF4] 7, whereas reaction of 2 with BAC gives the Lewis acid‐base adduct, [C6H4N(BAC)N(tBu)C(C12H8)][BF4] 8. Finally, reactions of 1 and 2 with KPPh2 result in electron transfer affording (PPh2)2 and the persistent radicals C6H4N(tBu)NC(C12H8). and C6H4NN(tBu)C(C12H8).. The detailed reaction mechanisms are also explored by extensive DFT calculations.
Parameter identification of transport PDE/nonlinear ODE cascade model for polymer extrusion with varying die gap
Authors: Toukhtarian Raffi , Darabi Mostafa , Hatzikiriakos Savvas , Atsbha Haile , Boulet Benoit 
Published: November 2020

AbstractA new transport PDE/nonlinear ODE cascade model is proposed to simulate extrudate thickness for polymer extrusion with varying die gap. The model is developed to simulate extrusion in extrusion blow moulding. A finite element method simulator is used as a reference for the proposed model to replicate its time dependent extrudate thickness profile. The parameters of the proposed model are identified by minimizing the response error between the proposed model and the finite element method simulator due to step inputs. The novel model is computationally cheap, suitable for controller design, and effective in simulating the extrudate thickness.
Caregiver engagement practices in National Cancer Institute Clinical Oncology Research Program settings: Implications for research to advance the field
Authors: Nightingale Chandylen L. , Sterba Katherine R. , McLouth Laurie E. , Kent Erin E. , Dressler Emily V. , Dest Alexandra , Snavely Anna C. , Adonizio Christian S. , Wojtowicz Mark , Neuman Heather B. , Kazak Anne E. , Carlos Ruth C. , Hudson Matthew F. , Unger Joseph M. , Kamen Charles S. , Weaver Kathryn E. 
Published: November 2020

BackgroundSupportive care interventions have demonstrated benefits for both informal and/or family cancer caregivers and their patients, but uptake generally is poor. To the authors' knowledge, little is known regarding the availability of supportive care services in community oncology practices, as well as engagement practices to connect caregivers with these services.MethodsQuestions from the National Cancer Institute Community Oncology Research Program (NCORP)'s 2017 Landscape Survey examined caregiver engagement practices (ie, caregiver identification, needs assessment, and supportive care service availability). Logistic regression was used to assess the relationship between the caregiver engagement outcomes and practice group characteristics.ResultsA total of 204 practice groups responded to each of the primary outcome questions. Only 40.2% of practice groups endorsed having a process with which to systematically identify and document caregivers, although approximately 76% were routinely using assessment tools to identify caregiver needs and approximately 63.7% had supportive care services available to caregivers. Caregiver identification was more common in sites affiliated with a critical access hospital (odds ratio [OR], 2.44; P = .013), and assessments were less common in safety‐net practices (OR, 0.41; P = .013). Supportive care services were more commonly available in the Western region of the United States, in practices with inpatient services (OR, 2.96; P = .012), and in practices affiliated with a critical access hospital (OR, 3.31; P = .010).ConclusionsAlthough many practice groups provide supportive care services, fewer than one‐half systematically identify and document informal cancer caregivers. Expanding fundamental engagement practices such as caregiver identification, assessment, and service provision will be critical to support recent calls to improve caregivers' well‐being and skills to perform caregiving tasks.
Maximum and Shape of Interfaces in 3D Ising Crystals
Authors: Gheissari Reza , Lubetzky Eyal 
Published: November 2020

AbstractDobrushin in 1972 showed that the interface of a 3D Ising model with minus boundary conditions above the xy‐plane and plus below is rigid (has O(1) fluctuations) at every sufficiently low temperature. Since then, basic features of this interface—such as the asymptotics of its maximum—were only identified in more tractable random surface models that approximate the Ising interface at low temperatures, e.g., for the (2+1)D solid‐on‐solid model. Here we study the large deviations of the interface of the 3D Ising model in a cube of side length n with Dobrushin's boundary conditions, and in particular obtain a law of large numbers for Mn, its maximum: if the inverse temperature β is large enough, then Mn/logn → 2/αβ as n → ∞, in probability, where αβ is given by a large‐deviation rate in infinite volume.We further show that, on the large‐deviation event that the interface connects the origin to height h, it consists of a 1D spine that behaves like a random walk in that it decomposes into a linear (in h) number of asymptotically stationary, weakly dependent increments that have exponential tails. As the number T of increments diverges, properties of the interface such as its surface area, volume, and the location of its tip, all obey CLTs with variances linear in T. These results generalize to every dimension d ≥ 3. © 2020 Wiley Periodicals LLC.
Effects of Maternally Transferred Egg Selenium on Embryo-Larval Survival, Growth, and Development in Arctic Grayling (Thymallus arcticus)
Authors: Brix Kevin V. , Baker Josh , Morris William , Ferry Kathleen , Pettem Connor , Elphick James , Tear Lucinda M. , Napier Robert , Adzic Marko , DeForest David K. 
Published: November 2020

Abstract
Selenium (Se) toxicity to fish is primarily manifested via maternal transfer to the eggs, which may result in adverse effects on larval survival and development. The present study assessed the effects of egg Se concentrations derived via maternal transfer on early life–stage development, survival, and growth of Arctic grayling (Thymallus arcticus), a salmonid species not previously assessed for Se sensitivity. Fish gametes were collected from 4 streams in Alaska known to exhibit a range of egg Se concentrations. Eggs were fertilized and reared in the laboratory from hatch through post-swim-up. Larvae were assessed for survival, length, and weight, as well as deformities (skeletal, craniofacial, fin-fold) and edema based on a graduated severity index. Eggs from a total of 47 females were collected, with egg Se concentrations ranging from 3.3 to 33.9 mg kg−1 dry weight. No relationships were observed between larval endpoints evaluated and parent females' egg, muscle, or whole-body Se concentrations. Therefore, Se 10% effective concentrations (EC10s) were defined as the maximum measured Se concentrations: &gt;33.9, &gt;17.6, and &gt;19.7 mg kg−1 dry weight for eggs, muscle, and whole-body tissue, respectively. Collectively, these data indicate that Arctic grayling are relatively insensitive to maternally transferred Se compared to other fish species. Environ Toxicol Chem 2021;40:380–389. © 2020 SETAC
Broad phenotypic spectrum of germ line 7p12.1 microdeletions encompassing the IKZF1 gene includes predisposition to acute lymphoblastic leukemia
Authors: Pastorczak Agata , Hogendorf Anna , Urbanska Zuzanna , Budzynska Edyta , Jesionek‐Kupnicka Dorota , Gach Agnieszka , Hawula Wanda , Smigiel Robert , Skiba Pawel , Sasiadek Maria , Lejman Monika , Constatinou Maria , Lipska‐Ziętkiewicz Beata S. , Mlynarski Wojciech 
Published: November 2020

AbstractMicrodeletions of 7p12.1 encompassing the IKZF1 gene locus are rare, with few cases reported. The common phenotype includes intellectual disability, overgrowth, and facial dysmorphism accompanied, albeit rarely, by congenital anomalies. Haploinsufficiency of IKZF1 predisposes individuals to childhood acute lymphoblastic leukemia (ALL). In this study, we comprehensively analyzed the frequency of 7p12.1 deletions among 4581 Polish individuals who underwent chromosomal microarray testing for unexplained developmental delay, intellectual disability, and/or congenital anomalies. Two unrelated individuals (0.04%) with a de novo interstitial 7p12.1 microdeletion encompassing IKZF1 were identified. One developed ALL. Analysis of the incidence and the phenotype of constitutional 7p12.1 microdeletion, which based on the previously annotated patients data in public databases and literature reports, revealed 21 cases including five patients diagnosed with ALL.
Risk of Incident Atrial Fibrillation With Zoledronic Acid Versus Denosumab: A Propensity Score–Matched Cohort Study
Authors: D'Silva Kristin M , Cromer Sara Jane , Yu Elaine W , Fischer Michael , Kim Seoyoung C 
Published: November 2020

ABSTRACT
Zoledronic acid (ZA) is an effective agent in osteoporosis and malignancy-related bone disease but may be associated with increased risk of atrial fibrillation (AF), although current studies disagree on this risk. To examine the risk of incident AF among patients receiving ZA compared with denosumab in the first year of treatment, we performed a new-user, active comparator cohort study including privately insured Americans between January 1, 2010, and June 30, 2019. Individuals aged ≥50 years without known arrhythmia or advanced kidney disease who initiated ZA were 1:1 propensity score (PS)-matched to individuals initiating denosumab in separate osteoporosis and malignancy cohorts. The primary outcome was incident diagnosis of AF (≥1 inpatient or ≥2 outpatient diagnostic codes) over 1 year. Secondary outcomes included stroke/transient ischemic attack (TIA) and nonvertebral fracture. In the osteoporosis cohort (n = 16,235 pairs), mean age was 71 years, and 93% were female. There was higher risk of AF with ZA compared with denosumab over 1 year (incidence rate [IR] = 18.6 versus 14.9 per 1000 person-years; hazard ratio [HR] = 1.25; 95% confidence interval [CI] 1.04 to 1.50). In the malignancy cohort (n = 7732 pairs), mean age was 70 years, and 66% were female. There was a numerically higher, albeit not statistically significant, risk of AF with ZA compared with denosumab over 1 year (IR = 46.9 versus 39.0 per 1000 person-years; HR = 1.19; 95% CI 1.00 to 1.43; p = 0.06). No difference in stroke/TIA rates occurred. In the malignancy cohort, ZA was less effective than denosumab at preventing nonvertebral fractures (HR = 1.32; 95% CI 1.01 to 1.74). Compared with denosumab, ZA treatment for osteoporosis and possibly for malignancy-related bone disease is associated with modestly increased risk of incident AF in the first year of treatment. © 2020 American Society for Bone and Mineral Research (ASBMR).
Community resilience and the acculturation expectations of the receiving community
Authors: Verbena Serena , Rochira Alessia , Mannarini Terri 
Published: November 2020

AbstractThe study addressed how communities cope with multiculturalism by exploring the relationship between community resilience (CR) and acculturation expectations held by a sample of Italian‐born. Specifically, the study aimed at detecting whether the perception of living in a community endowed with social (CR‐connection and caring) and material (CR‐resources) resources, along with the availability of individual assets (i.e., psychological resilience) encourage positive acculturation expectations (i.e., multiculturalism). Further, it also tested whether the perceived competitiveness of immigrants mediates the relationship between CR‐resources and acculturation expectations. A survey involving 619 participants living in the south of Italy completed a self‐report questionnaire. Results showed that competitiveness mediated the effects of CR‐resources on acculturation expectations. CR‐resources were related to increased perception of the competitiveness of immigrants, which, in turn, was associated with a reduced endorsement for multiculturalism and increased support for melting pot (i.e., assimilation) and exclusion, while CR‐connection and caring was unrelated to all acculturation expectations. Implications and limitations of the study are finally discussed.
Genetic and chemical control of coffee rust (Hemileia vastatrixBerk et Br.): impacts on coffee (Coffea arabicaL.) quality
Authors: Pereira Dyanna R , Nadaleti Denis HS , Rodrigues Eduardo C , da Silva Ackson D , Malta Marcelo R , de Carvalho Samuel P , Carvalho Gladyston R 
Published: November 2020

AbstractBACKGROUNDThe occurrence of diseases can alter coffee (Coffea arabica L.) metabolism, causing changes in the composition of coffee beans and beverage quality. However, little is known about which aspects of coffee quality are actually altered by rust (Hemileia vastatrix Berk et Br.) and by its main control methods. The effect of chemical and genetic methods for the control of coffee rust on the quality of coffee beans and beverage was investigated.RESULTSBoth genetic and chemical control reduce the damage caused by the disease in the composition of coffee beans. Genotypes with resistant ancestry, even with resistance breakdown, respond better to chemical control. The combination of genetic and chemical control favors an increase in the sugar content in the beans.CONCLUSIONSDespite the fact that both genetic and chemical control are effective in reducing disease damage regarding the chemical composition of beans, the quality potential of Timor Hybrid genotypes associated with the cancellation of rust expression through the joint action of genetic and chemical control favors the composition of beans and, consequently, the quantitative assessment of sensory attributes, adding value to the final product. © 2020 Society of Chemical Industry