bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with participation over time in the Avon Longitudinal Study of Parents and Children: a study using linked education and primary care data
Authors: Cornish Rosie P , Macleod John , Boyd Andy , Tilling Kate 
Published: September 2020

Abstract

Background
In observational research, choosing an optimal analysis strategy when variables are incomplete requires an understanding of the factors associated with ongoing participation and non-response, but this cannot be fully examined with incomplete data. Linkage to external datasets provides additional information on those with incomplete data, allowing examination of factors related to missingness.

Methods
We examined the association between baseline sociodemographic factors and ongoing participation in the Avon Longitudinal Study of Parents and Children. We investigated whether child and adolescent outcomes measured in linked education and primary care data were associated with participation, after accounting for baseline factors. To demonstrate the potential for bias, we examined whether the association between maternal smoking and these outcomes differed in the subsample who completed the 19-year questionnaire.

Results
Lower levels of school attainment, lower general practitioner (GP) consultation and prescription rates, higher body mass index (BMI), special educational needs (SEN) status, not having an asthma diagnosis, depression and being a smoker were associated with lower participation after adjustment for baseline factors. For example, the adjusted odds ratio (OR) for participation comparing ever smokers (by 18 years) with non-smokers was: 0.65, 95% CI (0.56, 0.75). The associations with maternal smoking differed between the subsample of participants at 19 years and the entire sample, although differences were small and confidence intervals overlapped. For example: for SEN status, OR = 1.19 (1.06, 1.33) (all participants); OR = 1.03 (0.79, 1.45) (subsample).

Conclusions
A range of health-related and educational factors are associated with ongoing participation in ALSPAC; this is likely to be the case in other cohort studies. Researchers need to be aware of this when planning their analysis. Cohort studies can use linkage to routine data to explore predictors of ongoing participation and conduct sensitivity analyses to assess potential bias.
The functional relation between mean motion resonances and Yarkovsky force on small eccentricities
Authors: Milić Žitnik I 
Published: September 2020

ABSTRACT
This work examines asteroid’s motion with orbital eccentricity in the range (0.1, 0.2) across the two-body mean motion resonance (MMR) with Jupiter due to the Yarkovsky effect. We calculated time delays dtr caused by the resonance on the mobility of an asteroid with the Yarkovsky drift speed. Our final results considered only asteroids that successfully cross over the resonance without close encounters with planets. We found a functional relation that accurately describes dependence between the average time lead/lag 〈dtr〉, the strength of the resonance SR, and the semimajor axis drift speed da/dt with asteroids’ orbital eccentricities in the range (0.1, 0.2). We analysed average values of 〈dtr〉 using this functional relation comparing with obtained values of 〈dtr〉 from the numerical integrations, which were performed in an ORBIT9 integrator with a very large number of test asteroids. We checked the validity of our previous functional relation, derived for asteroids’ orbital eccentricities in the range (0, 0.1), on the present results for eccentricities in the range (0.1, 0.2). Also, we tried to find a unique functional relation for the whole interested interval of asteroids’ orbital eccentricities (0, 0.2) and discussed it.
The effects of dwarf galaxies on the orbital evolution of galactic globular clusters
Authors: Garrow Turner , Webb Jeremy J , Bovy Jo 
Published: September 2020

ABSTRACT
We investigate the effect that dwarf galaxies have on the orbits, tidal histories, and assumed formation environment of Milky Way globular clusters. We determine the orbits of the Milky Way’s 150 globular clusters in a gravitational potential both with and without dwarf galaxies. We find that the presence of a small number of satellite galaxies can affect the orbits of many of the globular clusters. Over 12 Gyr, we find that the semimajor axis and orbital eccentricity of individual clusters fluctuate with dispersions of the order of $\sim 10{{\ \rm per\ cent}}$ and $\sim 4{{\ \rm per\ cent}}$, respectively. Outer clusters are more strongly affected by dwarf galaxies than inner clusters, with their semimajor axis and orbital eccentricities fluctuating by more than $\sim 15{{\ \rm per\ cent}}$ and $\sim 5{{\ \rm per\ cent}}$, respectively. Using detailed N-body simulations of select clusters, we find that altering their orbital histories can lead to different mass-loss rates and structural evolution. Furthermore, we caution against using kinematics alone to identify whether a Galactic cluster formed in situ or was accreted during a past merger event as these values are no longer conserved. The presence of dwarf galaxies causes the orbital energies and actions of individual clusters to evolve over time, spanning a wider range than that coming from random uncertainties in a cluster’s proper motions and radial velocity.
Constraints on cosmological parameters from gamma-ray burst peak photon energy and bolometric fluence measurements and other data
Authors: Khadka Narayan , Ratra Bharat 
Published: September 2020

ABSTRACT
We use measurements of the peak photon energy and bolometric fluence of 119 gamma-ray bursts (GRBs) extending over the redshift range of 0.3399 ≤ z ≤ 8.2 to simultaneously determine cosmological and Amati relation parameters in six different cosmological models. The resulting Amati relation parameters are almost identical in all six cosmological models, thus validating the use of the Amati relation in standardizing these GRBs. The GRB data cosmological parameter constraints are consistent with, but significantly less restrictive than, those obtained from a joint analysis of baryon acoustic oscillation and Hubble parameter measurements.
A Suzaku sample of unabsorbed narrow-line and broad-line Seyfert 1 galaxies – I. X-ray spectral properties
Authors: Waddell S G H , Gallo L C 
Published: September 2020

ABSTRACT
A sample of narrow-line Seyfert 1 (NLS1) and broad-line Seyfert 1 (BLS1) galaxies observed with Suzaku is presented. The final sample consists of 22 NLS1s and 47 BLS1s, for a total of 69 active galactic nuclei (AGNs) that are all at low redshift (z &lt; 0.5) and exhibit low host-galaxy column densities (&lt;1022${\rm cm}^{-2}\,$). The average spectrum for each object is fit with a toy model to characterize important parameters, including the photon index, soft excess, Compton hump (or hard excess), narrow iron line strength, luminosity, and X-ray Eddington ratio (Lx/LEdd). We confirm previous findings that NLS1s have steeper power laws and higher X-ray Eddington ratios, but also find that NLS1 galaxies have stronger soft and hard excesses than their BLS1 counterparts. Studying the correlations between parameters shows that the soft and hard excesses are correlated for NLS1 galaxies, while no such correlation is observed for BLS1s. Performing a principal component analysis (PCA) on the measured X-ray parameters shows that while the X-ray Eddington ratio is the main source of variations within our sample (PC1), variations in the soft and hard excesses form the second principal component (PC2) and it is dominated by the NLS1s. The correlation between the soft and hard excesses in NLS1 galaxies may suggest a common origin for the two components, such as a blurred reflection model. The presented Suzaku sample of Seyfert 1 galaxies is a useful tool for the analysis of the X-ray properties of AGNs, and for the study of the soft and hard excesses observed in AGNs.
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription
Authors: Declercq Marion , Biquand Elise , Karim Marwah , Pietrosemoli Natalia , Jacob Yves , Demeret Caroline , Barbezange Cyril , van der Werf Sylvie 
Published: September 2020

Abstract
Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A viruses are major human pathogens that are responsible for seasonal epidemics, but the interplay between viral proteins and cellular exonucleases has never been specifically studied. Here, using a stringent interactomics screening strategy and an siRNA-silencing approach, we identified eight cellular factors among a set of 75 cellular proteins carrying exo(ribo)nuclease activities or involved in RNA decay processes that support influenza A virus multiplication. We show that the exoribonuclease ERI1 interacts with the PB2, PB1 and NP components of the viral ribonucleoproteins and is required for viral mRNA transcription. More specifically, we demonstrate that the protein-protein interaction is RNA dependent and that both the RNA binding and exonuclease activities of ERI1 are required to promote influenza A virus transcription. Finally, we provide evidence that during infection, the SLBP protein and histone mRNAs co-purify with vRNPs alongside ERI1, indicating that ERI1 is most probably recruited when it is present in the histone pre-mRNA processing complex in the nucleus.
Predictive effect of salt intake on patient and kidney survival in non-dialysis CKD: competing risk analysis in older versus younger patients under nephrology care
Authors: Garofalo Carlo , Provenzano Michele , Andreucci Michele , Pisani Antonio , De Nicola Luca , Conte Giuseppe , Borrelli Silvio 
Published: September 2020

Abstract

Background
The optimal level of salt intake remains ill-defined in non-dialysis chronic kidney disease (CKD) patients under regular nephrology care. This unanswered question becomes critical in older patients who are exposed to higher risk of worsening of cardiorenal disease due to volemic changes.

Methods
In this pooled analysis of four prospective studies in CKD, we compared the risk of all-cause mortality and end-stage kidney disease (ESKD) between patients ≤65 and &gt;65 years of age stratified by salt intake level (&lt;6, 6–8 and &gt;8 g/day) estimated from two measurements of 24-h urinary sodium.

Results
The cohort included 1785 patients. The estimated glomerular filtration rate was 37 ± 21 mL/min/1.73 m2 overall, 41 ± 25 in younger patients and 34 ± 16 in older patients (P &lt; 0.001). The median 24-h urinary sodium excretion was 143 mEq [interquartile range (IQR) 109–182] in all, 147 (112–185) in younger patients and 140 (106–179) in older patients (P = 0.012). Salt intake was ≤6, 6–8 and &gt;8 g sodium chloride/day in 21.9, 26.2 and 52.0% of older patients and 18.6, 25.2 and 56.2% in younger patients, respectively (P = 0.145). During a median follow-up of 4.07 years we registered 383 ESKD and 260 all-cause deaths. In the whole cohort, the risks of ESKD and all-cause death did not differ by salt intake level. In older patients, ESKD risk [multi-adjusted hazard ratio (HR) and 95% confidence interval (CI)] was significantly lower at salt intakes of 6–8 g/day [HR 0.577 (95% CI 0.361–0.924)] and &gt;8 g/day [HR 0.564 (95% CI 0.382–0.833)] versus the reference group (&lt;6 g/day). Mortality risk was higher in older versus younger patients, with no difference across salt intake categories. No effect of salt intake on ESKD and mortality was observed in younger patients.

Conclusions
CKD patients under nephrology care show a moderate salt intake (8.4 g/day) that is lower in older versus younger patients. In this context, older patients are not exposed to higher mortality across different levels of salt intake, while salt intake &lt;6 g/day poses a greater risk of ESKD.
User-Perceived Negative Respiratory Symptoms Associated with Electronic Cigarette Use
Authors: Soule Eric K , Bode Kendall M , Desrosiers Abigail C , Guy Mignonne , Breland Alison , Fagan Pebbles 
Published: September 2020

AbstractIntroductionElectronic cigarettes (ECIGs) expose users to an aerosol containing chemicals, which could affect the respiratory system negatively. This study examined negative respiratory symptoms associated with ECIG use.MethodsIn 2019, adult current ECIG users from 24 US states who reported experiencing negative respiratory symptoms from ECIG use (n = 49; 44.9% women; mean age = 35.2, SD = 11.5) completed an online survey and brainstormed statements that completed the prompt: “A specific negative effect or symptom related to my breathing, nose, mouth, throat, or lungs that I have experienced from vaping/using my e-cigarette is...” Participants sorted the final list of 56 statements into groups of similar content and rated statements on how true they were for them. Multidimensional scaling analysis identified thematic clusters.ResultsEight ECIG use respiratory symptom clusters identified in analysis included Mucus and Congestion, Fatigue, Throat Symptoms, Breathing Problems, Mouth Symptoms, Chest Symptoms, Illness Symptoms, and Nose and Sinus Symptoms. Highly rated (ie, most common) symptoms included dry throat or mouth, fatigue during physical activity, coughing, shortness of breath, excessive phlegm, and bad taste in mouth. Mean cluster ratings did not differ based on lifetime cigarette smoking status (100 lifetime cigarettes smoked), but current cigarette smokers (ie, dual users) rated the Fatigue, Breathing Problems, Mucus and Congestion, and Nose and Sinus Symptoms clusters higher than noncurrent cigarette smokers.ConclusionsParticipant-identified respiratory symptoms perceived to be ECIG related, many similar to cigarette smoking symptoms. Future research should assess if these symptoms are associated with other negative health outcomes.ImplicationsECIG use exposes users to chemicals that may have negative health impacts on the respiratory system. Limited research has examined the broad range of negative respiratory symptoms associated with e-cigarette use. This study identified that ECIG–cigarette users perceive their ECIG use to be associated with negative respiratory symptoms. Many e-cigarette user-reported negative respiratory symptoms are similar to those associated with cigarette smoking, though some appear unique to e-cigarette use. Future research should continue to monitor respiratory symptoms reported by ECIG users and whether these are associated with health outcomes over time.
Maximal Dynamic Inspiratory Pressure Evaluation in Heart Failure: A Comprehensive Reliability and Agreement Study
Authors: da Silva Fabiola M F , Cipriano Gerson , Lima Alexandra C G B , Andrade Joanlise M L , Nakano Eduardo Y , Chiappa Gaspar R , Cahalin Lawrence P , Cipriano Graziella F B 
Published: September 2020

Abstract

Objective
The purpose of this study was to analyze the reliability (interrater and intrarater) and agreement (repeatability and reproducibility) properties of tapered flow resistive loading (TFRL) measures in patients with heart failure (HF).

Methods
For this cross-sectional study, participants were recruited from the cardiopulmonary rehabilitation program at the University of Brasilia from July 2015 to July 2016. All patients participated in the study, and 10 were randomly chosen for intrarater and interrater reliability testing. The 124 participants with HF (75% men) were 57.6 (SD = 1.81) years old and had a mean left ventricular ejection fraction of 38.9% (SD = 15%) and a peak oxygen consumption of 13.05 (SD = 5.3) mL·kg·min−1. The main outcome measures were the maximal inspiratory pressure (MIP) measured with a standard manovacuometer (SM) and the MIP and maximal dynamic inspiratory pressure (S-Index) obtained with TFRL. The S-Index reliability (interrater and intrarater) was examined by 2 evaluators, the S-Index repeatability was examined with 10 repetitions, and the reproducibility of the MIP and S-Index was measured with SM and TFRL, respectively.

Results
The reliability analysis revealed high S-Index interrater and intrarater reliability values (intraclass correlation coefficients [ICCs] of 0.89 [95% CI = 0.58–0.98] and 0.97 [95% CI = 0.89–0.99], respectively). Repeatability analyses revealed that 8 maneuvers were required to reach the maximum S-Index in 75.81% (95% CI = 68.27–83.34) of the population. The reproducibility of TFRL measures (S-Index = 68.8 [SD = 32.8] cm H2O; MIP = 66 [SD = 32.3] cm H2O) was slightly lower than that of the SM measurement (MIP = 70.1 [SD = 35.9] cm H2O).

Conclusions
The TFRL device provided a reliable intrarater and interrater S-Index measure in patients with HF and had acceptable repeatability, requiring 8 maneuvers to produce a stable S-Index measure. The reproducibilities of the S-Index, MIP obtained with SM, and MIP obtained with TRFL were similar.

Impact
TRFL is a feasible method to assess both MIP and the S-index as measures of inspiratory muscle strength in patients with HF and can be used for inspiratory muscle training, making the combined testing and training capabilities important in both clinical research and the management of patients with HF.
Paralogs and Off-Target Sequences Improve Phylogenetic Resolution in a Densely Sampled Study of the Breadfruit Genus (Artocarpus, Moraceae)
Authors: Gardner Elliot M , Johnson Matthew G , Pereira Joan T , Puad Aida Shafreena Ahmad , Arifiani Deby , Sahromi  , Wickett Norman J , Zerega Nyree J C 
Published: September 2020

AbstractWe present a 517-gene phylogenetic framework for the breadfruit genus Artocarpus (ca. 70 spp., Moraceae), making use of silica-dried leaves from recent fieldwork and herbarium specimens (some up to 106 years old) to achieve 96% taxon sampling. We explore issues relating to assembly, paralogous loci, partitions, and analysis method to reconstruct a phylogeny that is robust to variation in data and available tools. Although codon partitioning did not result in any substantial topological differences, the inclusion of flanking noncoding sequence in analyses significantly increased the resolution of gene trees. We also found that increasing the size of data sets increased convergence between analysis methods but did not reduce gene-tree conflict. We optimized the HybPiper targeted-enrichment sequence assembly pipeline for short sequences derived from degraded DNA extracted from museum specimens. Although the subgenera of Artocarpus were monophyletic, revision is required at finer scales, particularly with respect to widespread species. We expect our results to provide a basis for further studies in Artocarpus and provide guidelines for future analyses of data sets based on target enrichment data, particularly those using sequences from both fresh and museum material, counseling careful attention to the potential of off-target sequences to improve resolution. [Artocarpus; Moraceae; noncoding sequences; phylogenomics; target enrichment.]
Surgical Start Time Is Not Predictive of Microdiscectomy Outcomes
Authors: Maron Samuel Z. , Dan Joshua , Gal Jonathan S. , Neifert Sean N. , Martini Michael L. , Lamb Colin D. , Genadry Lisa , Rothrock Robert J. , Steinberger Jeremy , Rasouli Jonathan J. , Caridi John M. 
Published: September 2020

Study Design:
Retrospective analysis of clinical data from a single institution.

Objective:
The objective of this study was to assess the time of surgery as a possible predictor for outcomes, length of stay, and cost following microdiscectomy.

Summary of Background Data:
The volume of microdiscectomy procedures has increased year over year, heightening interest in surgical outcomes. Previous investigations have demonstrated an association between time of procedures and clinical outcomes in various surgeries, however, no study has evaluated its influence on microdiscectomy.

Methods:
Demographic and outcome variables were collected from all patients that underwent a nonemergent microdiscectomy between 2008 and 2016. Patients were divided into 2 cohorts: those receiving surgery before 2 pm were assigned to the early group and those with procedures beginning after 2 pm were assigned to the late group. Outcomes and patient-level characteristics were compared using bivariate, multivariable logistic, and linear regression models. Adjusted length of stay and cost were coprimary outcomes. Secondary outcomes included operative complications, nonhome discharge, postoperative emergency department visits, or readmission rates.

Results:
Of the 1261 consecutive patients who met the inclusion criteria, 792 were assigned to the late group and 469 were assigned to the early group. There were no significant differences in demographics or baseline characteristics between the 2 cohorts. In the unadjusted analysis, mean length of stay was 1.80 (SD=1.82) days for the early group and 2.00 (SD=1.70) days for the late group (P=0.054). Mean direct cost for the early cohort was $5088 (SD=$4212) and $4986 (SD=$2988) for the late cohort (P=0.65). There was no difference in adjusted length of stay or direct cost. No statistically significant differences were found in operative complications, nonhome discharge, postoperative emergency department visits, or readmission rates between the 2 cohorts.

Conclusion:
The study findings suggest that early compared with late surgery is not significantly predictive of surgical outcomes following microdiscectomy.