bluuebunny/crossref_metadata_2025_split huggingface dataset:
SORGHUM GENOTYPES RESPONSE TO INOCULATION WITH PHOSPHATE SOLUBILIZING BACTERIA
Authors: MATTOS BIANCA BRAZ , MARRIEL IVANILDO EVÓDIO , DE SOUSA SYLVIA MORAIS , LANA UBIRACI GOMES DE PAULA , SCHAFFERT ROBERT EUGENE , GOMES ELIANE APARECIDA , PAIVA CHRISTIANE ABREU DE OLIVEIRA 
Published: December 2020

Sorghum bicolor adapts to phosphorus (P) deficient soils through mechanisms that contribute to its absorption and solubilization, including the association with microorganisms. The direct application of rock phosphate (RP) and the inoculation with phosphate solubilizing bacteria (PSB) is a sustainable alternative for P supply to the crops. The aim of this study was to evaluate the effect of PSB inoculation of two sorghum genotypes with different P responses (BR007 - efficient and responsive and SC283 - efficient and non-responsive), cultivated in soil fertilized with RP and triple superphosphate (TSP), in greenhouse and field experiments. The sorghum genotypes were inoculated separately with the Bacillus strains that are efficient in P solubilization, B116 and B70, and cultivated under different P fertilization sources (TSP, RP, ½TSP + ½RP). The results suggest that the inoculation response was dependent on sorghum genotype, P source and microbial strain. Inoculation of the genotype BR007 significantly increased root biomass and grain P content under greenhouse conditions, as well as yield and grain P content in field experiments, but no effect was observed on genotype SC283. The use of PSB as bioinoculants, in combination with RP, is a promising alternative to reduce the use of synthetic fertilizers, contributing to the sustainable sorghum production.
“Nueva normalidad”, ¿nuevas formas de colonialidad?
Authors: PALERMO ZULMA 
Published: December 2020

RESUMEN Ante la ansiedad que produce la incertidumbre del tiempo por venir -el posible “después” de la pandemia que nos abruma- relevo en estas líneas, de manera general, lo que encuentro circula en los discursos político, mediático y académico en torno a esa cuestión. A la presencia masiva de las perspectivas más difundidas –siempre en los extremos de la dicotomía del pensamiento moderno- incorporo algunas otras emergencias nacidas en un lugar otro, sin por ello asumirlas como respuestas de total validez sino como apertura a la presencia de alternativas a la clara posibilidad del retorno al “horror social” y al “terricidio”.Palabras clave: Estado Nación. República. Democracia. Diseños alternativos. "New normality", new forms of coloniality?ABSTRACTFaced with the anxiety produced by the uncertainty of the time to come - the possible "after" the pandemic that overwhelms us - I take over in these lines, in a general way, what I find circulates in the political, media and academic discourses around this question . To the massive presence of the most widespread perspectives - always at the extremes of the dichotomy of modern thought - I incorporate some other emergencies born in a different place, without assuming them as responses of total validity but rather as an opening to the presence of alternatives to clear possibility of a return to "social horror" and "terricide".Keywords: Nation State. Republic. Democracy. Alternative Designs.
Fatores de Antropização no Isolamento e Distanciamento Sociais durante a Pandemia DE COVID-19: estudo de caso em cidade local da amazônia estuarina
Authors: FERNANDES JOSÉ GUILHERME DOS SANTOS , SERUFFO MARCOS CÉSAR DA ROCHA , PALHA RONDINELL AQUINO , SALES RENATA SILVA , SANTOS SUZANNE ALBUQUERQUE DOS 
Published: December 2020

RESUMOConsiderando a pandemia atual, este artigo aborda fatores de antropização que auxiliem indicadores de distanciamento social considerando realidades próprias da região amazônica. Foi conduzida a aplicação de formulário com moradores da cidade de São Caetano de Odivelas - Pará, localizada na zona estuarina do rio Amazonas, quanto à concordância, discordância ou indiferença por decorrência de determinações governamentais e de saúde pública. Observou-se que há dificuldade em relacionar demandas locais com as nacionais e globais, acarretando em comportamentos que podem comprometer a eficiência do isolamento social, assim, são propostos indicadores para distanciamento social.Palavras-chave: Indicadores. Coronavírus. Antropização. Isolamento Social. Distanciamento Social. Cidade Local.Anthropization factors in social isolation and distancing during the Covid-19 Pandemic: case study in a local city of estuarian amazon ABSTRACTConsidering the current pandemic, this article addresses anthropization factors that help social distancing indicators focused on realities specific to the Amazon region. A form was applied to residents of the city of São Caetano de Odivelas - Pará, located in the estuarine zone of the Amazon River, regarding agreement, disagreement or indifference due to government and public health determinations. It was observed that there is difficulty in relating local demands with national and global ones, resulting in behaviors that can compromise the efficiency of social isolation, thus, indicators for social distance are proposed.Keywords: Indicators. Coronavirus. Anthropization, Social Isolation. Social Distancing. Local City.
O peregrynacjach artysty i jego dzieła. Przypadek "Efektu melodramy" Feliksa Pęczarskiego
Authors: Świętosławska Agnieszka , Talanowa Anna 
Published: December 2020

Artykuł poświęcony jest obrazowi Efekt melodramy należącemu do zbiorow Państwowego Muzeum Sztuki w Niżnym Nowogrodzie w Rosji. Blisko 60 lat temu Andrzej Ryszkiewicz zidentyfikował go jako dzieło warszawskiego malarza z połowy XIX wieku, Feliksa Pęczarskiego (1804/1805–1862). Tym samym badacz ten przyczynił się do poszerzenia wiedzy o nielicznie niestety zachowanym dorobku niezwykle ciekawego, głuchego artysty, ktory w swoich czasach zasłynął nie tylko jako autor biedermeierowskich portretow, ale przede wszystkim komicznych scen rodzajowych wykorzystujących karykaturalną charakterystykę fizjonomii postaci i groteskowo przerysowaną mimikę. Atrybucja zaproponowana przez Ryszkiewicza została w pełni przyjęta zarowno przez środowisko polskich badaczy, jak rownież rosyjskich muzealnikow opiekujących się kolekcją w Niżnym Nowogrodzie. Jednakże dotychczas nie została wyjaśniona kwestia sposobu, w jaki obraz trafił do odległej rosyjskiej prowincji.
Niniejszy artykuł stanowi probę rozwiązania tej zagadki. Według notatki XIX-wiecznego pamiętnikarza Franciszka Ksawerego Preka, ktory znał Pęczarskiego osobiście, ten ostatni podczas kilkuletniego pobytu na Lubelszczyźnie (gdzie powstał omawiany obraz) portretował bliżej nieokreśloną generałową rosyjską. Do zbiorow muzealnych Efekt melodramy trafił w 1924 roku z zamku we wsi Jurino. Przeprowadzona analiza, bazująca na kwerendzie w dawnych inwentarzach kolekcji zamkowej oraz badaniach historii dwoch arystokratycznych rodow związanych z majątkiem, Szeremietiewow i Skobelewow, pozwoliła wskazać osobę, ktora potencjalnie mogła być pierwszym nabywcą obrazu.
Uma relação dialógica entre o universo literário e músico-teatral na obra de Cordel “Fogo Encantado”
Authors: Licursi Maria Beatriz , Leonido Levi Fernandes , Morgado Elsa Maria 
Published: December 2020

A literatura de cordel, profundamente inserida no mundo da vida do homem nordestino, se constitui hoje em uma tradição cultural tão forte e arraigada que marca a sua identidade, de forma indelével. Historicamente considerada uma herança portuguesa o presente artigo é um estudo comparativo dialógico entre o cordel do Brasil e o cordel de Portugal e suas influências nos movimentos artísticos, tendo como objeto de pesquisa na cultura brasileira o grupo cordelista Cordel do Fogo Encantado, apresentando uma reflexão sobre a adaptação da cultura popular de nosso país a favor da cultura progressiva e a estética da oralidade como experiência da teatralidade aliada a uma musicalidade moldada por/para essa experiência teatral.
Computational Study of the Front-end Downforce Enhancing Aerodynamic Elements in Sports Cars
Authors: Salhan Pranav 
Published: December 2020

Abstract
While designing sports cars, getting the aerodynamic balance of the vehicle is very important. Aerodynamic elements to create rear downforce are studied extensively while, this research tries to recognize the various ways of developing effective front end down force producing devices. The most widely used add-on devices include the front splitter, canards and underbody vortex generators. CFD simulations are employed to study these devices on the widely acknowledged MIRA fastback model. ANSYS Fluent CFD software was used with the efficient k- ε model to get accurate results while avoiding expensive experimentation costs. Reduction in lift force with the help of these elements generally leads to high drag force. This study aims to find out the most suitable and versatile devices. The average lift decrement on the addition of front aerodynamic elements was ΔC l = 0.0778 while the increase in drag was ΔC d = 0.0393.
CircBCBM1 Promotes Breast Cancer Brain Metastasis via miR-125a/BRD4 Axis
Authors: Fu Bo , Liu Wei , Li Peng , Pan Li , Li Ke , Cai Peiying , Meng Min , Wang Yiting , Zhang Anqi , Tang Wenqiang , An Meng 
Published: December 2020

Abstract
Background: Accumulating evidence indicates that circular RNAs (circRNAs) play critical roles in tumorigenesis and progression of various cancers. We previously identified a novel upregulated circRNA, circBCBM1 (hsa_circ_0001944), in the context of breast cancer brain metastasis. However, the potential biological function and molecular mechanism of circBCBM1 in breast cancer brain metastasis remain largely unknown.Methods: In this reserch, we validated the expression and characterization of circBCBM1 through RT-qPCR, Sanger sequencing, RNase R assay and fluorescence in situ hybridization (FISH). Functional experiments were performed to determine the effect of circBCBM1 on growth and metastasis of 231-BR cells both in vitro and in vivo. The regulatory mechanisms among circBCBM1, miR-125a (has-miR-125a-5p), and BRD4 (bromodomain containing 4) were investigated by RNA immunoprecipitation (RIP), RNA pull-down, luciferase reporter assay and western blot. Results: Our findings demonstrated that circBCBM1 is a stable and cytoplasmic circRNA. Functionally, silencing of circBCBM1 led to decreased proliferation and migration of 231-BR cells whereas elevated circBCBM1 expression showed reverse effects in vitro. These findings were confirmed in vivo in mouse models, as knockdown of circBCBM1 significantly decreased growth and brain metastases of 231-BR cells. Mechanistically, circBCBM1 functions as an endogenous miR-125a sponge to inhibit miR-125a activity, resulting in the upregulation of BRD4 expression and subsequent upregulation of MMP9 (matrix metallopeptidase 9) through Sonic hedgehog (SHH) signaling pathway. Importantly, circBCBM1 was markedly upregulated in the breast cancer brain metastasis cells and clinical tissue and plasma samples; besides, the overexpression of circBCBM1 in primary cancerous tissues was associated with shorter brain metastasis-free survival (BMFS) of breast cancer patients.Conclusions: These findings indicate that circBCBM1 is involved in breast cancer brain metastasis via circBCBM1/miR-125a/BRD4 axis, which sheds light on the pathogenic mechanism of circBCBM1 and provides translational evidence that circBCBM1 may serve as a novel diagnostic or prognostic biomarker and potential therapeutic target for breast cancer brain metastasis.
UPF1 Promotes Chemoresistance to Oxaliplatin Through Maintenance of Stemness by Increasing Phosphorylated TOP2A in Colorectal Cancer.
Authors: Zhu Congcong , Zhang Long , Zhao Senlin , Dai Weixing , Xu Yun , Zhang Yuqin , Zheng Hongtu , Sheng Weiqi , Xu Ye 
Published: December 2020

Abstract
Background: UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 on oxaliplatin resistance in colorectal cancer (CRC) remains unknown.Methods: Firstly, we investigated the clinical relevance of UPF1 in CRC patients. Then, we explored the influence of UPF1 on chemoresistance to oxaliplatin in vitro and in vivo. Finally, we disclosed the underlying mechanisms of oxaliplatin resistance induced by UPF1.Results: UPF1 is upregulated in CRC and overexpression of UPF1 more likely results in recurrence in CRC patients and predicts a poorer overall survival (OS). UPF1 maintains stemness in CRC cell lines and promotes chemoresistance to oxaliplatin in CRC. UPF1-induced oxaliplatin resistance can be associated with interaction with TOP2A and increasing phosphorylated TOP2A.Conclusions: UPF1 was overexpressed and predicted a poor prognosis in CRC. UPF1 enhanced the stemness and chemoresistance to oxaliplatin by interaction with TOP2A and increase of phosphorylated TOP2A in CRC, which may provide a new therapy strategy for chemoresistance to oxaliplatin in CRC patients.
The financial burden of tuberculosis-affected households in China, 2017
Authors: Xu Caihong , Liu Yan , Shewade Hemant Deepak , Kathiresan Jeyashree , Ruan Yunzhou , Xia Yinyin , Lixia Wang , Zhang Hui , Zhao Yanlin , Wang Li 
Published: December 2020

Abstract
BackgroundDrug-susceptible pulmonary tuberculosis patients notified and treated under national tuberculosis program, ChinaMethodsWe conducted a cross-sectional study in six provinces in 2017 to assess the burden and distribution of health expenditure costs among tuberculosis-affected households and analyze related risk factors. The data was collected through face-to-face questionnaire survey. Intensity of financial burden was the median positive overshoot beyond a threshold that defined as annual total (direct and indirect) costs exceeding 20% of the pre-TB annual household income.ResultsOf 1147 patients, median (interquartile range) total costs due to tuberculosis care were US$965.5(461.8, 2059.3). Costs due to pre-treatment care accounted for 46.3% and direct costs accounted for 82.5% for total costs. Median (interquartile range) intensity of catastrophic costs was 32%(11%, 88%). Living below poverty line, household size less than four, employment in informal sector, receiving treatment from tuberculosis dispensary and hospitalization were independent predictors of associated with higher financial burden.ConclusionDespite free tuberculosis care services, the health expenditure due to tuberculosis were high among tuberculosis-affected households.Trial registrationThe Ethics Committee of Chinese Center of Disease Control and Prevention approved the study (No.201625, dated 22 November 2016).
Effect of Ultrasound on L-leucine Production by Corynebacterium Glutamicum in Fed-batch Culture
Authors: Zhang Yufu , Chen Zhichao , Sun Pengjie , Xu Qingyang , Chen Ning 
Published: December 2020

Abstract
Background: Various process intensifications are proposed to improve process efficiency, quality, and safety of fermented products. With the market significantly growing, the production process of L-leucine needs significant improvements to increased productivity and yield. Ultrasound, a process intensification, is an emerging and fast-growing technology due to its wide range of applications in food science and fermentation industry. Results: By optimizing the time points and parameters of ultrasound, the biomass of Corynebacterium glutamicum CP was significantly improved. The response surface methodology was adopted to create prediction profiler model and optimize sonication conditions. C. glutamicum CP fermentation at conditions of ultrasonic power of 94 W/L, frequency of 25 kHz, interval of 31 min, and duration of 37 s produced 52.89 g/L of L-leucine in 44 h, increased by 21.6% compared with the control. The production performance of L-leucine was also improved under ultrasonic treatment. Moreover, the cell morphology of C. glutamicum CP were more irregular, elongated, and swollen cells under the ultrasonic condition. The cell permeability of C. glutamicum CP and the activity of key enzymes with ultrasonic treatment were significantly higher than the control. Conclusions: We successfully obtain the optimum ultrasonic conditions to produce L-leucine in fed-batch culture. The results indicate that ultrasonication is an efficient intensification process for enhancing fermentation to produce L-leucine from C. glutamicum CP.
The Risk of Cardiac-related Mortality in Stage IIIA-N2 Non-small Cell Lung Cancer: Analysis of the Surveillance, Epidemiology, and End Results Database
Authors: Sun Xin , Men Yu , Wang Jianyang , Bao Yongxing , Yang Xu , Zhao Maoyuan , Sun Shuang , Yuan Meng , Ma Zeliang , Hui Zhouguang 
Published: December 2020

Abstract
Background: We aimed to investigate the association between postoperative radiotherapy (PORT) and cardiac-related mortality for patients with ⅢA-N2 non-small cell lung cancer (NSCLC) by the Surveillance, Epidemiology, and End Results (SEER) database.Methods: The United States (US) population based SEER database were queried for cardiac-related mortality among patients with ⅢA-N2 NSCLC. Cardiac-related mortality was compared between PORT and Non-PORT group. Accounting for mortality from other causes, Gray’s test compared cumulative incidences of cardiac-related mortality between both groups. Univariate and multivariate analysis were performed using the competing risk model.Results: From 1988 to 2016, 7290 patients met the inclusion criteria: 3386 patients treated with PORT and 3904 patients treated with Non-PORT. The 5-year overall incidence of cardiac-related mortality was 3.01% in PORT group and 3.26% in Non-PORT group. Older age, male sex, squamous cell lung cancer, earlier year of diagnosis and earlier T stage were independent adverse factors for cardiac-related mortality. However, PORT use wasn’t associated with an increase in the hazard for cardiac-related mortality (subdistribution hazard ratio [SHR]=0.99, 95% confidence interval [95% CI], 0.78–1.24, p=0.91). When evaluating cardiac-related mortality in each time period, the overall incidence of cardiac-related mortality was decreased over time. There were no statistically significant differences based on PORT use in all time periods.Conclusions: With a median follow-up of 25 months, no significant differences were found in cardiac-related mortality between PORT and Non-PORT for ⅢA-N2 NSCLC patients.
A New Ceramic Sr2Fe8O18: Crystal Structure and Analysis of Application on Solid Electrolytes
Authors: Ren Zan , Liao Qingwei , Kang Binglin , Liao Kexuan , Chen Liyin , Jiang Wenxiao , Qin Lei , Wang Likun 
Published: December 2020

Abstract
All-solid-state batteries have been expected to overcome the safety problem of present lithium-ion batteries including organic liquid electrolytes. The materials with high ionic conductivity are urgently needed. In this paper, we reported a new ionic crystal Sr2Fe8O18 which can be applicated on solid electrolyte. Sr2Fe8O18 is a typical p-type semiconductor and shows a layered monoclinic crystal structure. The resistivities of Sr2Fe8O18 in the temperature range of 20 ~ 145 °C were above 107 Ω•cm. The microstructure of Sr2Fe8O18 was flaky, and the size of flaks were 1 µm ~ 5 µm. The E- P curve suggested that it was a ferroelectric semiconductor and had small ferroelectric effect. The dielectric response study (Cole-Cole plot) showed that Sr2Fe8O18 had two separated relaxation time, each of which contained a group of relaxation. The ionic conductivity σ of the sample was calculated to be 0.2196 × 10− 4 S/cm. The conductive mechanism which confirmed by the results of First principle calculation at 300K is mainly sublattice vacancy cation diffusion with self-diffusion coefficient D of 1.794 × 10− 5cm2/s. Fe ion has two dimensional diffusion path (x and y axial), and Sr ion has on dimensional diffusion path (x axial). The crystal structure of Sr2Fe8O18 shows tremendous potential application on the solid electrolyte preparation.
The Potential Role of miRNA-19b-3p and miRNA-320c in Patients with Moderate Bronchial Asthma
Authors: Aripova Akmaral , Akparova Almira , Bersimbaev Rakhmetkazhy 
Published: December 2020

Background:
Bronchial Asthma (BA) is a complex heterogeneous disease with a number
of molecular immunopathological mechanisms underlying airway inflammation, hyperreactivity,
and bronchial remodeling. MicroRNAs are important regulators in the pathogenesis and progression
of chronic respiratory diseases, including BA.

Objective:
The aim of the study is to investigate the level of expression of cell-free circulating
miR-19b-3p and miR-320c in the blood plasma by comparing their plasma levels with IL-4 in the
moderate BA patients and control group.

Methods:
The level of expression miR-19b-3p and miR-320c were evaluated by qRT-PCR using
the comparative threshold cycle (Ct) method. U6 small nuclear RNA was taken as an endogenous
control. The content of IL - 4 in blood plasma was determined by using ELISA.

Results:
miR-19b-3p and miR-320c were significantly dysregulated in moderate asthmatic patients
in comparison with control group. The area under the ROC curve of miR-19b-3p and miR-320c
showed 0.8088 (95% CI 0.6925 to 0.9251, P value =0.0001) and 0,9048 (95% CI 0,7792 to 1,000,
P value <0,0001), respectively. BA patients showed a considerably positive correlation between
the expression level of microRNA-320c and IL-4 levels.

Conclusion:
These cell-free circulating microRNAs are probably deregulated in other inflammatory/
pathological diseases, so they could be useful to understand the molecular pathogenesis of BA
or to investigate the “inflammatory reaction” in this disease.
Anosmia pada COVID-19: Studi Neurobiologi
Authors: Aditya Dwi Martha Nur 
Published: December 2020

Abstract— A few months ago there was Covid-19 virus outbreak by SARS-CoV-19 virus which has clinical manifestations, one of which is Anosmia. Anosmia cause patient was experienced smell’s decreasing which causes psychological problems that loss of comfort and appetite. This condition may also cause imunity’s decreasing in patient. Anosmia in Covid-19 patients could be temporary, if the body's immune system is maintained in good condition, one of the factors is continuing provide healthy and nutritious food intake, even though in tasteless conditions. Therefore, this article can be used as an educational material for the public, how to understand the neurobiological conditions of anosmia in Covid-19, further to avoid depressed due to loss of taste which could be lead to loss appetite. Keywords: Covid-19, Anosmia, Neurobiology
Abstrak— Beberapa bulan lalu telah terjadi penyebaran wabah virus Covid-19 oleh SARS-CoV-19 virus yang memiliki manifestasi klinis salah satunya adalah Anosmia. Kondisi anosmia menyebabkan kondisi pasien mengalami penurunan daya penciuman yang menyebabkan gangguan psikologis berupa kehilangan rasa nyaman dan kehilangan napsu makan. Kondisi ini sudah barang tentu akan menyebabkan penurunan daya imunitas pasien. Anosmia pada pasien Covid-19 bersifat sementara, apabila daya imunitas tubuh tetap dijaga dalam keadaan baik, salah satu faktornya adalah tetap memberikan asupan makan sehat dan bergizi, meskipun dalam kondisi tasteless. Oleh karena itu, dengan adanya artikel ini dapat digunakan sebagai bahan edukasi kepada khalayak, bagaimana memahami kondisi anosmia pada Covid-19 secara neurobiologi, sehingga dapat menghindarkan rasa depresi karena kehilangan rasa akan makaman yang dapat menyebabkan turunnya napsu makan. Kata kunci: Covid-19, Anosmia, Neurobiologi