bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Melanoma Concerns Questionnaire (MCQ‐28); refinement of the EORTC QLQ‐MEL38 module
Authors: Winstanley Julie , White Edward , Saw Robyn , Young Teresa , Burmeister Bryan , Nikolic Dejan , Busto‐Cornide Iria , Iglesias‐Pena Nicolás , Boyle Frances 
Published: October 2019

AbstractObjectiveFew patient‐reported outcome measures (PROMs) have been developed that adequately measure the patient‐experience following diagnosis and treatment of melanoma. Building on previous research, which developed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Module (QLQ‐MEL38), the aim of this study was to further test the hypothesised domain structure and psychometric properties of the phase 3 module, in a new larger sample of melanoma patients.MethodsMelanoma patients (n = 270) were recruited from four countries (Australia, England, Serbia, and Spain). Patients completed the EORTC core questionnaire (QLQ‐C30), the QLQ‐MEL38, and a sociodemographic survey. Using this new larger dataset, comparisons were made with the hypothesised domain structure of the EORTC phase 3 module using principal component analysis. Items which formed subscales in a revised domain structure were then tested for goodness of fit (GoF) to the Rasch model.ResultsThe original hypothesised and final domain structures were similar but not identical. Twenty‐four items (83%) loaded onto the same distinct subscales previously generated by phase 3, and item‐by‐item comparison of the two pattern matrices indicated an extremely close match. Ten items were removed from the QLQ‐MEL38 phase 3 module, and rescoring of some items was required. Four subscales, together with five individual items, comprised the final instrument.ConclusionThe newly developed measure (named the Melanoma Concerns Questionnaire; MCQ‐28) was found to tap into several important psychosocial domains of concern to melanoma patients, particularly those being managed in “usual” clinic settings.
New Colorimetric DNA Sensor for Detection of Campylobacter jejuni in Milk Sample Based on Peroxidase‐Like Activity of Gold/Platinium Nanocluster
Authors: Dehghani Zahra , Hosseini Morteza , Mohammadnejad Javad , Ganjali Mohammad Reza 
Published: October 2019

AbstractA new colorimetric DNA sensor for trace Campylobacter jejuni DNA genome in food samples was investigated. 30 mer DNA probe‐based on hipo gene of Campylobacter jejuni and 12 cytosine nucleotide in tail without any chemical modification was used as the sensing element. 12 cytosine nucleotide utilized as a scaffold for stabilization of Au/Pt nanoclusters. Peroxidase like activity of Au/Pt nanocluster probe with the addition of bacterial target DNA and hybridization process decreased. The experiment showed that step by step increase in bacterial target DNA gradually decreased peroxidase activity, which was linear. Limit of detection for this bacterial DNA sensor was 20 pM and superiority of this DNA sensor for detection of Campylobacter jejuni DNA in comparison with other target DNA was significant. The method was successfully applied to the analysis of bacterial target DNA in milk samples, with results similar to those obtained by the PCR methodology as comparative method.
Rapid, Greener and Ultrasound Irradiated One‐Pot Synthesis of 4‐(Substituted‐1H‐Pyrazol‐4‐yl)Methylene)‐3‐Isopropylisoxazol‐5(4H)‐ones and Their In Vitro Anticancer Activity
Authors: Bhatt Tejal D. , Gojiya Dinesh G. , Kalavadiya Prakash L. , Joshi Hitendra S. 
Published: October 2019

AbstractIn the current research framework, an efficient and greener synthesis has been developed for novel isoxazole scaffolds one‐pot three‐component reaction. We have developed a new method for convenient and rapid synthesis of 4‐(substituted‐1H‐pyrazol‐4‐yl)methylene)‐3‐isopropylisoxazol‐5(4H)‐ones via one‐pot three‐component reaction between methyl 4‐methyl‐3‐oxovalerate, hydroxylamine hydrochloride and various pyrazole aldehyde in the presence of pyridine as a base, water:EtOH (1:1) act as greener solvent under conventional and ultrasonic irradiation methods. From the comparisition between conventional and ultrasound‐assisted synthesis, it was observed that the ultrasound‐assisted method gave 82–96% yields in 30–45 min against 70–90 min required to get 66–79% yields by a conventional method. All the final compounds were characterized by FT‐IR, 1H NMR, 13C NMR and Mass spectroscopic analysis. Some selected compounds were evaluated for their in‐vitro anticancer activity against a panel of 60 different human tumor cell lines. All the selected compounds were highly active against the leukemia cancer cell line.
Photothermal Composite Nanomaterials for Multimodal Tumor Therapy under MRI Guidance
Authors: Chen Yongkang , Zhao Jiulong , Wang Shige , Zhang Zhilun , Zhang Jing , Wang Yunfeng , Xie Pei 
Published: October 2019

AbstractMultifunctional nanomaterials for cancer therapy has attracted researchers’ attention for decades. In this study, a unique oxidative method using KMnO4 or K2MnO4 as oxidizing agents to oxidize dopamine (DA) to polydopamine (PDA) was reported. The oxidizing agent was reduced to MnOx to form MnOx/PDA composite NPs. Afterwards, the MnOx/PDA composite NPs were surface‐modified with bovine serum albumin (BSA) to form a multifunctional theranostic agent, named MnOx/PDA@BSA NPs, with improved colloidal stability and biocompatibility. Such a material would become a photothermal nanoagent, since the PDA renders the composite NPs an admirable photothermal transforming ability with the photothermal conversion efficiency of 27.06%. Meanwhile, as a commonly used T1 contrast agent, manganese (Mn2+) endowed the MnOx/PDA@BSA NPs with MRI ability, rendering the as‐synthesized MnOx/PDA composite NPs a capability of imaging guided multi‐modal tumor therapy. Moreover, the formed MnOx/PDA@BSA NPs were used for drug loading, which was found to own the tunable drug loading and controlled drug releasing capacity. The as‐prepared composite NPs were successfully used for the combined tumor chemotherapy and photothermal therapy in vitro and in vivo. This research provides insights into the development of conjugated polymer‐based nanomaterial for various biomedical applications, especially in imaging guided cancer therapy.
Metal‐Organic Frameworks of Cu3(BTC)2 Catalyzed Cascade C‐H Activation/C‐S Coupling/C‐O Cyclization Reaction Strategy: One‐Pot Efficient Synthesis of Phenoxathiines
Authors: Liu Na , Chao Fei , Yan Jiaying , Huang Nian‐Yu , Ren Zhi‐Lin , Wang Long 
Published: October 2019

AbstractA novel synthetic strategy of cascade C−H activation/C−S coupling/C−O cyclization reaction by using metal organic framework material Cu3(BTC)2 as catalyst is investigated. In this method, Cu3(BTC)2 can effectively catalyze the hydroxylation of the ortho‐Csp2‐H of benzenethiol, and then the coupling reaction and intramolecular C−O coupling cyclization. Phenoxathiine derivatives are efficiently prepared by one‐pot method. In our work, a series of phenoxathiin derivatives were obtained in good yield by this method. At the same time, the reaction mechanism was explored through conditional control experiments.
Highly Selective Conversion of HMF to 1‐hydroxy‐ 2,5‐hexanedione on Pd/MIL‐101(Cr)
Authors: Yang Yanliang , Xie Yanfu , Deng Dongsheng , Li Dongmi , Zheng Min , Duan Ying 
Published: October 2019

AbstractSaturated cyclohexene water was used as the reductant for the preparation of Pd/MIL‐101(Cr). The catalysts were characterized by XRD, N2 adsorption/desorption isotherms, XPS, TEM, FTIR, ICP‐AES and in‐situ FTIR spectra of adsorbed pyridine. The water saturated by cyclohexene was proved to be an effective reductant to produce metallic Pd catalyst. The texture of MIL‐101(Cr) was kept well after the introduction of Pd to MIL‐101(Cr). The hydrogenation of HMF to 1‐hydroxy‐2,5‐hexanedione (HHD) was conducted in water using Pd/MIL‐101(Cr) as catalyst. After reacted for 6 h at 413 K 4 MPa H2, up to 82% yield of HHD was achieved without acid additives. The MIL‐101(Cr) acted both as support and acid catalyst generated from the open Cr3+. The stability of the catalyst was investigated to find that the TOFs decreased slightly after the catalyst was used. The decline in the catalytic activity was discussed and ascribed to the condensation of intermediates on the active sites and the partly aggregate of Pd.
Nanostructured Metal–Organic Conjugated Coordination Polymers with Ligand Tailoring for Superior Rechargeable Energy Storage
Authors: Xie Jian , Cheng Xue‐Feng , Cao Xun , He Jing‐Hui , Guo Wei , Li Dong‐Sheng , Xu Zhichuan J. , Huang Yizhong , Lu Jian‐Mei , Zhang Qichun 
Published: October 2019

AbstractConjugated coordination polymers have become an emerging category of redox‐active materials. Although recent studies heavily focus on the tailoring of metal centers in the complexes to achieve stable electrochemical performance, the effect on different substitutions of the bridging bonds has rarely been studied. An innovative tailoring strategy is presented toward the enhancement of the capacity storage and the stability of metal–organic conjugated coordination polymers. Two nanostructured d‐π conjugated compounds, Ni[C6H2(NH)4]n (Ni‐NH) and Ni[C6H2(NH)2S2]n (Ni‐S), are evaluated and demonstrated to exhibit hybrid electrochemical processes. In particular, Ni‐S delivers a high reversible capacity of 1164 mAh g−1, an ultralong stability up to 1500 cycles, and a fully recharge ability in 67 s. This tailoring strategy provides a guideline to design future effective conjugated coordination‐polymer‐based electrodes.
Engineering Halide Perovskite Crystals through Precursor Chemistry
Authors: Li Bo , Binks David , Cao Guozhong , Tian Jianjun 
Published: October 2019

AbstractThe composition, crystallinity, morphology, and trap‐state density of halide perovskite thin films critically depend on the nature of the precursor solution. A fundamental understanding of the liquid‐to‐solid transformation mechanism is thus essential to the fabrication of high‐quality thin films of halide perovskite crystals for applications such as high‐performance photovoltaics and is the topic of this Review. The roles of additives on the evolution of coordination complex species in the precursor solutions and the resulting effect on perovskite crystallization are presented. The influence of colloid characteristics, DMF/DMSO‐free solutions and the degradation of precursor solutions on the formation of perovskite crystals are also discussed. Finally, the general formation mechanism of perovskite thin films from precursor solutions is summarized and some questions for further research are provided.
Controlling Homogenous Spherulitic Crystallization for High‐Efficiency Planar Perovskite Solar Cells Fabricated under Ambient High‐Humidity Conditions
Authors: Angmo Dechan , Peng Xiaojin , Seeber Aaron , Zuo Chuantian , Gao Mei , Hou Qicheng , Yuan Jian , Zhang Qi , Cheng Yi‐Bing , Vak Doojin 
Published: October 2019

AbstractThe influence of precursor solution properties, fabrication environment, and antisolvent properties on the microstructural evolution of perovskite films is reported. First, the impact of fabrication environment on the morphology of methyl ammonium lead iodide (MAPbI3) perovskite films with various Lewis‐base additives is reported. Second, the influence of antisolvent properties on perovskite film microstructure is investigated using antisolvents ranging from nonpolar heptane to highly polar water. This study shows an ambient environment that accelerates crystal growth at the expense of nucleation and introduces anisotropies in crystal morphology. The use of antisolvents enhances nucleation but also influences ambient moisture interaction with the precursor solution, resulting in different crystal morphology (shape, size, dispersity) in different antisolvents. Crystal morphology, in turn, dictates film quality. A homogenous spherulitic crystallization results in pinhole‐free films with similar microstructure irrespective of processing environment. This study further demonstrates propyl acetate, an environmentally benign antisolvent, which can induce spherulitic crystallization under ambient environment (52% relative humidity, 25 °C). With this, planar perovskite solar cells with ≈17.78% stabilized power conversion efficiency are achieved. Finally, a simple precipitation test and in situ crystallization imaging under an optical microscope that can enable a facile a priori screening of antisolvents is shown.
“I think at first glance people would not expect me to be interested in science”: Exploring the racialized science experiences of high school students of color
Authors: Visintainer Tammie 
Published: October 2019

AbstractThe underrepresentation of high school students of color in advanced science courses and the need to increase racial diversity in science fields is well documented. The persistence of racial disparities in science suggests that factors influencing participation include and extend beyond those currently being explored. This study explores how high school students of color make sense of racialized narratives about who does and can do science in circulation in society and their lives, and how this shapes their positioning and identity construction in science. Using interviews and surveys this study examines youths' accounts of their racialized science experiences, including how they envision scientists, make sense of racial disparities in the science community, and navigate their positioning in science. In addition, this study examines how youths' sense of their science ability, as a salient aspect of science identity, shapes the forms of navigation accessible to them, and thus, the futures they imagine in science. By sharing the complexity of students' sense making and the tensions they express as they negotiate their personal goals, science experiences, and messages they receive from racialized narratives, findings highlight the disproportionate work youth of color in this study do, as well as their resilience to navigate racialized narratives in science. This research sheds light on the experiences of high school students of color at a time in their schooling when they are making decisions about who they can become and the possible futures available to them. Implications from this study promote centering race within a critical, sociocultural, and ecological context when exploring identity construction for youth of color in science. Furthermore, findings underscore the need to create learning experiences that provide opportunities for youth of color to author narratives for their own possibilities of belonging and becoming in science in order to support inclusive pathways.
Discrete Painlevé equation, Miwa variables and string equation in 5d matrix models
Authors: Mironov A. , Morozov A. , Zakirova Z. 
Published: October 2019

AbstractThe modern version of conformal matrix model (CMM) describes conformal blocks in the Dijkgraaf-Vafa phase. Therefore it possesses a determinant representation and becomes a Toda chain T-function only after a peculiar Fourier transform in internal dimensions. Moreover, in CMM Hirota equations arise in a peculiar discrete form (when the couplings of CMM are actually Miwa time-variables). Instead, this integrability property is actually independent of the measure in the original hypergeometric integral. To get hypergeometric functions, one needs to pick up a very special T-function, satisfying an additional “string equation”. Usually its role is played by the lowest L-1 Virasoro constraint, but, in the Miwa variables, it turns into a finite-difference equation with respect to the Miwa variables. One can get rid of these differences by rewriting the string equation in terms of some double ratios of the shifted T-functions, and then these ratios satisfy more sophisticated equations equivalent to the discrete Painleve equations by M. Jimbo and H. Sakai (q-PVI equation). They look much simpler in the q-deformed (“5d“) matrix model, while in the “continuous” limitq→ 1 to 4d one should consider the Miwa variables with non-unit multiplicities, what finally converts the simple discrete Painleve q-PVI into sophisticated differential Painleve VI equations, which will be considered elsewhere.
Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling
Authors: Ethaeb Ali M. , Mohammad Mohammad A. , Madkhali Yahya , Featherby Sophie , Maraveyas Anthony , Greenman John , Ettelaie Camille 
Published: October 2019

AbstractAccumulation of tissue factor (TF) within cells leads to cellular apoptosis mediated through p38 and p53 pathways. In this study, the involvement of Src1 in the induction of TF-mediated cell apoptosis, and the mechanisms of Src1 activation were investigated. Human coronary artery endothelial cell (HCAEC) were transfected with plasmids to express the wild-type TF (TFWt-tGFP), or a mutant (Ser253 → Ala) which is incapable of being released from cells (TFAla253-tGFP). The cells were then activated with PAR2-agonist peptide (SLIGKV-NH) and the phosphorylation of Src and Rac, and also the kinase activity of Src were assessed. Transfected cells were also pre-incubated with pp60c Src inhibitor, FAK inhibitor-14, or a blocking anti-β1-integrin antibody prior to activation and the phosphorylation of p38 as well as cellular apoptosis was examined. Finally, cells were co-transfected with the plasmids, together with a Src1-specific siRNA, activated as above and the cellular apoptosis measured. Activation of PAR2 lead to the phosphorylation of Src1 and Rac1 proteins at 60 min regardless of TF expression. Moreover, Src phosphorylation and kinase activity was prolonged up to 100 min in the presence of TF, with a significantly higher magnitude when the non-releasable TFAla253-tGFP was expressed in HCAEC. Inhibition of Src with pp60c, or suppression of Src1 expression in cells, reduced p38 phosphorylation and prevented cellular apoptosis. In contrast, inhibition of FAK had no significant influence on Src kinase activity or cellular apoptosis. Finally, pre-incubation of cells with an inhibitory anti-β1-integrin antibody reduced both Src1 activation and cellular apoptosis. Our data show for the first time that the over-activation of Src1 is a mediator of TF-induced cellular apoptosis in endothelial cells through a mechanism that is dependent on its interaction with β1-integrin.
Anxiety in Children with Selective Mutism: A Meta-analysis
Authors: Driessen Jim , Blom Jan Dirk , Muris Peter , Blashfield Roger K. , Molendijk Marc L. 
Published: October 2019

AbstractThis study evaluates the current conceptualization of selective mutism (SM) as an anxiety disorder in the DSM-5 using a meta-analytic approach. In the absence of any systematic assessment of anxiety in the field of SM, we pooled prevalence data of comorbid anxiety disorders in a random-effects meta-analysis. On the basis of 22 eligible studies (N = 837), we found that 80% of the children with SM were diagnosed with an additional anxiety disorder, notably social phobia (69%). However, considerable heterogeneity was present, which remained unexplained by a priori specified moderators. The finding that SM is often diagnosed in combination with anxiety disorders, indicates that these disorders are not discrete, separable categories. Moreover, this finding does not help to elucidate the relation between SM and anxiety as an etiological mechanism or symptomatic feature. Broadening our research strategies regarding the assessment of anxiety is paramount to clarify the role of anxiety in SM, and allow for proper classification.
A multi-authority approach to various predicate encryption types
Authors: van de Kamp Tim , Peter Andreas , Jonker Willem 
Published: October 2019

Abstract
We propose a generic construction for fully secure decentralized multiauthority predicate encryption. In such multiauthority predicate encryption scheme, ciphertexts are associated with one or more predicates from various authorities and only if a user has a set of decryption keys that evaluates all predicates to true, the user is able to recover the message. In our decentralized system, anyone can create a new authority and issue decryption keys for their own predicates. We introduce the concept of a multi-authority admissible pair encoding scheme and, based on these encodings, we give a generic conversion algorithm that allows us to easily combine various predicate encryption schemes into a multi-authority predicate encryption variant. The resulting encryption schemes are proven fully secure under standard subgroup decision assumptions in the random oracle model. Finally, by instantiating several concrete multi-authority admissible pair encoding schemes and applying our conversion algorithm, we are able to create a variety of novel multi-authority predicate encryption schemes.
Clinical efficacy and safety of apatinib combined with S-1 in advanced esophageal squamous cell carcinoma
Authors: Zhao Jian , Lei Junmei , Yu Junyan , Zhang Chengyan , Song Xuefeng , Zhang Ninggang , Wang Yusheng , Zhang Suxiang 
Published: October 2019

Summary
Background Esophageal cancer is a very common malignant tumor in China, especially esophageal squamous cell carcinoma (ESCC), but there is currently no effective treatment for patients after first-line chemotherapy failure. Apatinib has shown promising outcomes in treatment with various solid tumors. Objectives To evaluate the clinical efficacy and safety of apatinib combined with S-1 in the treatment of advanced ESCC patients after first-line chemotherapy failure. Methods In this prospective study, fifteen patients with advanced ESCC who failed first-line chemotherapy were enrolled from Nov 2016 to Apr 2019. Patients received the combination therapy with apatinib (250-500 mg, once daily) plus S-1 (40–60 mg based on body surface area, twice daily). Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), disease control rate (DCR) and objective response rate (ORR). Adverse events (AEs) were recorded to evaluate the safety. Results A total of 12 patients were included in the efficacy analysis. The median PFS was 6.23 months, and the median OS was 8.83 months. Two (16.67%) patients achieved partial remission, 9 patients (75.00%) achieved stable disease and 1 (8.33%) patient achieved progressive disease. DCR and ORR was 91.67%and 16.67%, respectively. Most frequent AEs were hypertension, myelosuppression, weakness, hemorrhage, hand-foot syndrome, total bilirubin elevation, sick, proteinuria, oral ulcer, loss of appetite, and transaminase elevation. The most AEs were in grade I~II. Conclusion The combination therapy of apatinib plus S-1 was effective and well tolerated in the treatment of advanced ESCC patients after first-line chemotherapy failure. The combination therapy has the potential to be a potent therapeutic option for advanced ESCC patients after first-line
chemotherapy failure.