bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy
Authors: Bengoechea Rocio , Findlay Andrew , Bhadra Ankan , Shao Hao , Stein Kevin , Pittman Sara , Daw Jil , Gestwicki Jason E. , True Heather , Weihl Conrad C. 
Published: January 2020

AbstractDominant mutations in the HSP70 co-chaperone DNAJB6 cause a late onset muscle disease termed limb girdle muscular dystrophy type 1D (LGMD1D), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms underlying dysfunction are not well understood. Using yeast, cell culture, and mouse models of LGMD1D, we find that the toxicity associated with disease-associated DNAJB6 requires its interaction with HSP70, and that abrogating this interaction genetically or with small molecules is protective. In skeletal muscle, DNAJB6 localizes to the Z-disc with HSP70. Whereas HSP70 normally diffuses rapidly between the Z-disc and sarcoplasm, the rate of HSP70’s diffusion in LGMD1D mouse muscle is diminished likely because it has an unusual affinity for the Z-disc and mutant DNAJB6. Treating LGMD1D mice with a small molecule inhibitor of the DNAJ-HSP70 complex re-mobilizes HSP70, improves strength and corrects myopathology. These data support a model in which LGMD1D mutations in DNAJB6 are a gain-of-function disease that is, counter-intuitively, mediated via HSP70 binding. Thus, therapeutic approaches targeting HSP70:DNAJB6 may be effective in treating this inherited muscular dystrophy.
The role of orientation towards sustainability in supply chains
Authors: Silva Minelle E. , Alves Ana Paula Ferreira , Dias Patricia , Nascimento Luis Felipe Machado 
Published: January 2020

PurposeThe purpose of this paper is to analyse how a company’s orientation enables sustainable practices in its supply chains. Specifically, it focusses on how the strategic orientation of a company may stimulate new behaviours in supply chains.Design/methodology/approachTwo in-depth qualitative case studies were conducted. Each company’s orientation to sustainable supply chains was studied using cross-case analysis.FindingsThe organisations in this study have a market-driving (i.e. proactive) orientation instead of market-driven (i.e. responsive) behaviour. Using analysis from the process of change for sustainability and explaining some challenges faced by both organisations, findings indicate that a corporate strategy of sustainability modified the companies’ management processes, even for the company that changed its orientation during the time (i.e. sustainability was not the main strategy at first). Practical examples of actions are provided to illustrate the study’s conclusion that a corporate orientation towards sustainability is an enabling factor in developing sustainable supply chain management (SCM).Research limitations/implicationsStrategic management plays an important role in a company’s orientation towards sustainability – internally and throughout its supply chains. Based on the findings, future research should measure the effect of a company’s orientation on sustainable SCM.Practical implicationsThis study contributes to the understanding of companies’ strategic orientations and explores ways to introduce sustainability into supply chains.Originality/valueThe paper examines an underexplored debate regarding to how strategic orientations are related to sustainable SCM, focussing on both market-driving (i.e. proactive) and market-driven (i.e. responsive) orientations.
Embedding third sector psychology services within the probation environment: an alternative to MHTRs
Authors: Fowler James C. , Price Robyn Catherine , Burger Kirsty , Mattei Alice Jennifer , McCarthy Ashley Mary , Lowe Fiona , Sathiyaseelan Thuthirna 
Published: January 2020

Purpose
The use of mental health treatment requirements (MHTRs) has not proven to be successful at meeting the mental health needs of the probation population in the UK, largely through underuse of the requirement or lack of available services. The paper aims to discuss this issue.

Design/methodology/approach
This paper investigates a method of meeting those needs without the use of MHTRs by embedding third sector services within the probation environment.

Findings
Results indicate a significant impact after a six-month follow-up in symptomology across measures of depression, anxiety, general distress and social functioning; also indicated is a significant result on recidivism, with 74 per cent of participants committing no further offences in the 12 months following treatment.

Originality/value
These results represent the only evaluation of embedded, third sector mental health services in a probation environment in the UK, and highlight a further need to embed specialist mental health services within the probation environment and generalise that practice to other forms of service structure and therapeutic methodology.
An environmental scan of virtual and augmented reality services in academic libraries
Authors: Greene David , Groenendyk Michael 
Published: January 2020

Purpose
The growing popularity of virtual and augmented reality (VR and AR) technologies, and increased research into their educational uses, has seen them appearing in a significant number of academic libraries. Little is known, however, about how many libraries have actually adopted these technologies or how they have structured library services around them. The purpose of this paper is to answer these questions.

Design/methodology/approach
The authors surveyed the websites of the Association of Research Libraries (ARL) member libraries to gather information about the availability of VR and AR equipment as well as information about how access is provided. Recorded details about these services included information about staffing, dedicated space, software, what type of technology was offered and whether or not the technology was lent out or only made available for in-library use.

Findings
Results of the research project showed that a significant number of ARL-member libraries do offer access to VR technology. AR technology was much less widespread. The most common technologies offered were the Oculus Rift and HTC Vive. The technology was most typically offered for in-library use only. There were few details about staff or what software was offered to be used with the technology.

Originality/value
While there is growing research around how VR and AR is being used in education, little research has been undertaken into how libraries are adopting these technologies. This paper summarizes the research that has been done so far and also takes the next step of providing a larger picture of how widespread the adoption of VR and AR technologies has been within academic libraries, as well as how access to these technologies is being provided.
Light mediates the relationship between community diversity and trait plasticity in functionally and phylogenetically diverse tree mixtures
Authors: Williams Laura J. , Cavender‐Bares Jeannine , Paquette Alain , Messier Christian , Reich Peter B. 
Published: January 2020

Abstract

Trait values affect how plants function, with consequences that propagate through scales of ecological organization to affect ecosystem function. However, the pathway connecting trait expression to ecosystem function is complicated by feedbacks: trait expression may vary within species in response to community diversity, and trait expression also determines a community's functional diversity. The predictability and consequences of interactions between trait expression and community diversity are poorly understood, particularly in forest ecosystems.

Here we quantify the extent to which light access—which past studies suggest affects trait expression and differs as a result of interactions among plants—differs consistently with community diversity and explains intraspecific trait variation in trees. In a common garden, trees of five angiosperm and seven gymnosperm species were planted to form 37 communities ranging widely in species and functional diversity whereby confounding environmental variation was minimized. We sampled leaves of each species to characterize intraspecific variation within and among communities in three traits—leaf size, specific leaf area and nitrogen concentration—and estimated each leaf's access to light.

We found that light access explained a substantial portion of trait variation within all species, species tended to receive less light in more diverse communities and effects of community diversity on trait expression tended to be mediated by light.

Synthesis. This study shows that community diversity affects leaf trait plasticity in young trees through its effects on light availability. Moreover, trait responses across angiosperms and gymnosperms were remarkably similar, showing that shared biophysical constraints overwhelm divergent evolutionary histories. Together, these results illustrate how leaf trait expression responds to, and may subsequently shape, diversity in young tree communities in largely predictable ways via resource‐based interactions, with consequences that may scale from individuals to ecosystems.
The role of fluid reasoning in word recognition
Authors: Guerin Julia M. , Sylvia Allison M. , Yolton Kimberly , Mano Quintino R. 
Published: January 2020

BackgroundMultiple perspectives on cognitive development, including Cattell's Investment Theory (1963, 1987), suggest that fluid reasoning (Gf) is foundational to the development of academic knowledge and skills. Yet little is known of the role that Gf may play in reading achievement, particularly in comparison with a larger literature demonstrating an influential role of crystallised intelligence (Gc) in word recognition. Given the novelty of word recognition for early readers, it is likely that Gf plays an influential role in literacy acquisition.MethodUsing regression‐based mediation analysis, the present study examined performance of preschool children (n = 154) and college‐aged adults (n = 114) on measures of Gf, Gc, phonemic decoding and word recognition.ResultsResults show that Gf has a significant direct effect on word recognition among preschoolers but not among adults. Moreover, among preschoolers, Gf exerted an effect indirectly on word recognition through phonemic decoding (i.e., Gf → phonemic decoding →word recognition), as well as through a serial and joint mechanism of Gc and phonemic decoding (i.e., Gf →Gc →phonemic decoding →word recognition). However, among adults, Gf exerted an effect onto word recognition only through this joint and serial mechanism and not singularly through phonemic decoding.ConclusionsPresent findings link theories of cognitive development with models of reading development, suggesting that while Gf may both directly and indirectly invest in word recognition during early literacy acquisition, this investment may shift in adulthood such that Gf exerts only indirect effects through crystallised knowledge and skills (i.e., Gc and phonemic decoding).
Intraductal placement of a fully covered metal stent with a long string for distal malignant biliary obstruction without endoscopic sphincterotomy: Prospective multi‐center feasibility study
Authors: Inoue Tadahisa , Suzuki Yuta , Okumura Fumihiro , Naitoh Itaru , Sano Hitoshi , Ibusuki Mayu , Kitano Rena , Kobayashi Yuji , Ito Kiyoaki , Yoneda Masashi 
Published: January 2020

BackgroundStent migration and sludge clogging are characteristic problems in biliary covered self‐expandable metal stent (SEMS) placement. Intraductal placement without endoscopic sphincterotomy (ES) may help reduce their occurrence. We examined the feasibility of intraductal placement of a covered SEMS with a long string without ES in patients with unresectable distal malignant biliary obstruction (MBO).MethodsThis was a prospective multi‐center observational study. Forty patients with distal MBO were enrolled between July 2016 and August 2018. We evaluated recurrent biliary obstruction (RBO), adverse events other than RBO, and reintervention associated with intraductal placement without ES.ResultsBoth technical and functional success rates were 100% (40/40). The rate of adverse events other than RBO was 5% (2/40). The RBO rate was 33% (13/40), and the median time to RBO was 339 days. RBO was mainly caused by overgrowth on the papillary side, occurring in six patients; all such patients had pancreatic cancer and a distance between the papilla and the stricture of ≤20 mm. Other causes were overgrowth at the hepatic side in two patients and sludge in five patients. No instances of stent migration occurred. Success rates of endoscopic transpapillary reintervention and stent removal using the string were 92% (12/13) and 77% (10/13), respectively.ConclusionsIntraductal placement without ES using a long‐stringed covered SEMS is a promising option for distal MBO. Since overgrowth on the papillary side is frequent, the procedure should be avoided in patients with short distances between the stricture and the papilla. (Clinical Trial Registry: UMIN000023370)
Pain in persons with chronic venous leg ulcers: A systematic review and meta‐analysis
Authors: Leren Lena , Johansen Edda , Eide Hilde , Falk Ragnhild S. , Juvet Lene K. , Ljoså Tone M. 
Published: January 2020

AbstractPain is a serious problem for patients with leg ulcers. Research mainly focuses on dressing‐related pain; however, chronic background pain may be just as devastating. Our main objective was to describe the prevalence and characteristics of wound‐related background pain in persons with chronic venous leg ulcers. We performed a systematic review to synthesise data from quantitative studies. Studies were eligible if they reported original baseline‐ or cross‐sectional data on background pain in chronic venous leg ulcers. The initial search identified 2454 publications. We included 36 descriptive and effect studies. The pooled prevalence of wound‐related background pain (from 10 studies) was 80% (95% CI 65‐92%). The mean pain intensity score (from 27 studies) was 4 (0‐10 numeric rating scale) (95% CI 3.4‐4.5). Other pain characteristics could not be synthesised. We identified few sufficiently high‐quality studies on prevalence and intensity of wound‐related background pain in patients with chronic venous leg ulcers. Four of five persons experience mild to moderate pain. Because of poor quality of pain assessment and report, we believe that the available research does not provide a sufficiently nuanced understanding of background pain in this patient group.
An experiential approach to developing radiological content for public health nursing: Lessons from a nuclear disaster
Authors: Kawasaki Chie , Kitamiya Chiaki , Yoshida Koji , Omori Junko , Porter Sarah , Asahara Kiyomi 
Published: January 2020

AbstractObjectiveThis study identified the radiological content required for PHNs and public health nursing students based on PHNs’ experiences caring for people affected by the 2011 Fukushima Daiichi nuclear power plant accident.DesignWe used qualitative research, interviews, and content analysis.SampleParticipants were eight PHNs employed by local governments in Fukushima and neighboring prefectures.ResultsSix content themes regarding the nuclear disaster were identified: (a) basic knowledge about radiation, (b) public health nursing activities in emergency exposure situations, (c) management in emergency exposure situations, (d) consultation to support residents affected by the nuclear disaster, (e) activities in the existing exposure situations, and (f) disaster preparedness in the planned exposure situations. Necessary content shifted depending on the phase of the nuclear disaster recovery.ConclusionsThe use of the experiences of PHNs after the nuclear power plant accident to inform PHNs and public health nursing students will enable PHNs to respond appropriately and support people without difficulties. Comprehensive radiation content is needed to address the range of situations caused by nuclear disaster.
Analysis of testicular variables, semen motility and kinematics‐derived indexes in boar using a CASA‐Mot system
Authors: Madrigal‐Valverde Mónica , Bittencourt Rodrigo F. , Brito Lindomar S. , Lents Maicon P. , Santos Elisiane S. , Valverde‐Abarca Anthony 
Published: January 2020

AbstractThe present study aimed to evaluate differences in area, volume and testicular weight among groups related to breed and age of boar and establish associations between testicular parameters and seminal characteristics. Seminal quality has been studied using computer‐assisted semen analysis (CASA) systems that reduce the subjectivity of kinematic parameters. Based on the data obtained through this system, sperm quality indexes and their derived parameters have been assessed to identify a better estimator for determining movement and velocity parameters. We also established indexes of velocity and sperm movement for boar semen. To this end, we evaluated 191 ejaculate samples from 63 boars. Differences related to the effects of season and age on quality boar semen were found (p ≤ .05) in the animal groups. Indexes were established for velocity and sperm movement based on CASA‐Mot, and we proposed a sperm movement index (SMI) and sperm velocity index (SVI) with the CASA‐Mot variables. Correlations were found (p < .05) among sperm indexes and CASA‐Mot variables. Boar characteristics were found to be associated with some CASA‐Mot variables, and the estimated SMI and SVI indexes predicted a greater variation in kinematic characteristics compared to the parameters evaluated separately using the CASA‐Mot system.
A model for the growth and development of wave‐dominated deltas fed by small mountainous rivers: Insights from the Elwha River delta, Washington
Authors: Zurbuchen Julie , Simms Alexander R. , Warrick Jonathan A. , Miller Ian M. , Ritchie Andrew 
Published: January 2020

AbstractObservations from ground‐penetrating radar, sediment cores, elevation surveys and aerial imagery are used to understand the development of the Elwha River delta in north‐western Washington, USA, which prograded as a result of two dam removals in late 2011. Swash‐bar, foreshore and swale depositional elements are recognized within ground‐penetrating radar profiles and sediment cores. A model for the growth and development of small mountainous river wave‐dominated deltas is proposed based on observation of both the fluvial and deltaic settings. If enough sediment is available in the fluvial system, mouth‐bars form after higher than average river discharge events, creating a large platform seaward of the subaqueous delta plain. Swash‐bars form concurrently or within a month of mouth‐bar deposition as a result of wave action. Fair‐weather waves drive swash‐bar migration landward and in the direction of littoral drift. The signature of swash‐bar welding to the shoreline is landward‐dipping reflections, as a result of overwash processes and slipface migration. However, most swash‐bars are eroded by the river mouth, as only 10 of the 37 swash‐bars that formed between August 2011 and July 2016 survived within the Elwha River delta. The swash‐bars that do survive either amalgamate onto the shoreline or an earlier deposited swash‐bar, forming a single larger barrier at the delta front. In asymmetrical deltas, the signature of swash‐bar welding is more likely to be preserved on the downdrift side of the delta, where formation is more likely and accommodation behind newer swash‐bars preserves older deposits. On small mountainous river deltas, welded swash‐bars may be more indicative of a large sediment pulse to the system, rather than large hydrological events.
Categories are in flux, but their computational representations are fixed: That's a problem
Authors: Gupta Prashant , Gahegan Mark 
Published: January 2020

AbstractAs research advances, our conceptual understanding also changes. Computational approaches do little to recognize the evolution that occurs at the conceptual level during the research process. This can result in misunderstanding between knowledge producers and consumers and so inhibit the reusability of outcomes. In this article, we describe how changes at the conceptual level can be represented, along with related changes to data and methods, and how appropriate connections between these various artefacts can be maintained. To demonstrate these ideas, we show how categories used in remote sensing and land cover analysis change over time and how these changes are linked to various research activities. We present a new system (called AdvoCate) that augments typical GIS and remote sensing functionality with a conceptual model of categories that can undergo change, and that also captures the cause of conceptual change and its extent. We argue that concepts and categories should be represented explicitly and richly within GIS, because without this, we have a poor idea of what our modeled entities really mean, and by implication how they should be used appropriately. We demonstrate the usefulness of this deeper representation using examples of category evolution from a land cover mapping exercise.
Lumbar Spine Loading During Dressage Riding
Authors: Mason Catherine , Greig Matt 
Published: January 2020

Context: Lower back pain is prevalent in horse riders as a result of the absorption of repetitive and multiplanar propulsive forces from the horse. Global positioning system technology provides potential for in vivo measurement of planar loading during riding. Objective: To quantify the uniaxial loading at the lumbar and cervicothoracic spine during dressage elements. Design: Repeated measures, randomized order. Setting: Equestrian arena. Patients (or Other Participants): Twenty-one female dressage riders. Intervention(s): Each rider completed walk, rising trot, sitting trot, and canter trials in a randomized order. A global positioning system unit was placed within customized garments at C7 and L5, collecting triaxial accelerometry data at 100 Hz. Outcome Measures: PlayerLoad based on the rate of change of acceleration and calculated in the anteroposterior (AP), mediolateral, and vertical planes during each trial. Results: There was no significant main effect for global positioning system location in the AP (P = .76), mediolateral (P = .88), or vertical (P = .76) planes. There was a significant main effect for pace in all trials (P < .001), with successive elements eliciting significantly greater loading (P ≤ .03) in all planes in the order walk < rising trot < canter < sitting trot. There was a significant placement × element interaction only in the AP plane (P = .03) with AP loading greater at L5 during walk, rising trot, and canter trials, but greater at C7 during sitting trot. Conclusions: The significant main effect for dressage element was indicative of greater pace of the horse, with faster pace activities eliciting greater loading in all planes. In vivo measurement of spinal accelerometry has application in the objective measurement and subsequent management of lumbar load for riders.