bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multispectral imaging detects gastritis consistently in mouse model and in humans
Authors: Bazin Thomas , Martinez-Herrera Sergio Ernesto , Jobart-Malfait Aude , Benezeth Yannick , Boffety Matthieu , Julié Catherine , Emile Jean-François , Michel Valérie , Goudail François , Touati Eliette , Marzani Franck , Lamarque Dominique 
Published: November 2020

AbstractGastritis constitutes the initial step of the gastric carcinogenesis process. Gastritis diagnosis is based on histological examination of biopsies. Non-invasive real-time methods to detect mucosal inflammation are needed. Tissue optical properties modify reemitted light, i.e. the proportion of light that is emitted by a tissue after stimulation by a light flux. Analysis of light reemitted by gastric tissue could predict the inflammatory state. The aim of our study was to investigate a potential association between reemitted light and gastric tissue inflammation. We used two models and three multispectral analysis methods available on the marketplace. We used a mouse model of Helicobacter pylori infection and included patients undergoing gastric endoscopy. In mice, the reemitted light was measured using a spectrometer and a multispectral camera. We also exposed patient’s gastric mucosa to specific wavelengths and analyzed reemitted light. In both mouse model and humans, modifications of reemitted light were observed around 560 nm, 600 nm and 640 nm, associated with the presence of gastritis lesions. These results pave the way for the development of improved endoscopes in order to detect real-time gastritis without the need of biopsies. This would allow a better prevention of gastric cancer alongside with cost efficient endoscopies.
Occurrence and risks of antibiotics in an urban river in northeastern Tibetan Plateau
Authors: Kuang Yuzhu , Guo Xiaoyu , Hu Jingrun , Li Si , Zhang Ruijie , Gao Qiang , Yang Xi , Chen Qian , Sun Weiling 
Published: November 2020

AbstractThere is a dearth of information on the occurrence and risks of antibiotics in the urban rivers from plateau areas. This study investigated 83 antibiotics in water and sediments of an urban river and effluents of sewage treatment plants (E-STPs) in Xining, Qinghai (northeastern Tibetan Plateau). Fifty-three antibiotics were detected, and the concentrations of individual antibiotics varied in the range of undetected (ND)-552 ng/L in water, ND-164 ng/g in sediments, and ND-3821 ng/L in E-STPs. Seasonal differences of antibiotic concentrations were significant for water samples (p < 0.05) but insignificant for sediments (p > 0.05). In urban area, E-STP is the main source of antibiotics in the river, while runoff from manured cropland contributes partially to antibiotics in the river in the suburban area. The antibiotic compositions in water were different from those in sediments, but were similar to those in E-STPs. Notably, because of strong solar radiation and long sunshine hours in the plateau area, low levels of quinolones, which are sensitive to photolysis, were observed in river water. Moreover, norfloxacin and enrofloxacin, observed in urban river from other regions of China, were not detected in the Huangshui River water. The occurrence of ofloxacin, erythromycin, roxithromycin, clarithromycin, and trimethoprim in E-STPs may induce a possible risk to antibiotic resistance evolution. Trimethoprim, anhydroerythromycin, sulfamethoxazole, sulfapyridine, and clindamycin in river water could pose low to medium risks to aquatic organisms. Further investigation on the occurrence and distribution of antibiotic resistance genes in the Huangshui River is urgently needed.
Patulin suppresses α1-adrenergic receptor expression in HEK293 cells
Authors: Pillay Yashodani , Nagiah Savania , Phulukdaree Alisa , Krishnan Anand , Chuturgoon Anil A. 
Published: November 2020

AbstractPatulin (PAT) is a common mycotoxin contaminant of apple products linked to impaired metabolic and kidney function. Adenosine monophosphate activated protein kinase (AMPK), abundantly expressed in the kidney, intercedes metabolic changes and renal injury. The alpha-1-adrenergic receptors (α1-AR) facilitate Epinephrine (Epi)-mediated AMPK activation, linking metabolism and kidney function. Preliminary molecular docking experiments examined potential interactions and AMPK-gamma subunit 3 (PRKAG3). The effect of PAT exposure (0.2–2.5 µM; 24 h) on the AMPK pathway and α1-AR was then investigated in HEK293 human kidney cells. AMPK agonist Epi determined direct effects on the α1-AR, metformin was used as an activator for AMPK, while buthionine sulphoximine (BSO) and N-acetyl cysteine (NAC) assessed GSH inhibition and supplementation respectively. ADRA1A and ADRA1D expression was determined by qPCR. α1-AR, ERK1/2/MAPK and PI3K/Akt protein expression was assessed using western blotting. PAT (1 µM) decreased α1-AR protein and mRNA and altered downstream signalling. This was consistent in cells stimulated with Epi and metformin. BSO potentiated the observed effect on α1-AR while NAC ameliorated these effects. Molecular docking studies performed on Human ADRA1A and PRKAG3 indicated direct interactions with PAT. This study is the first to show PAT modulates the AMPK pathway and α1-AR, supporting a mechanism of kidney injury.
The impacts of acid suppression on duodenal microbiota during the early phase of severe acute pancreatitis
Authors: Ma Xiao , Huang Libin , Huang Zhiyin , Jiang Jinsun , Zhao Chong , Tong Huan , Feng Zhe , Gao Jinhang , Liu Rui , Zhang Mingguang , Zhou Ming , Tan Qinghua , Liu Ling , Tang Chengwei 
Published: November 2020

AbstractDuodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of ACDs on duodenal microbiota during the early phase of SAP is still unknown. This randomized controlled clinical trial evaluated the impacts of esomeprazole (Eso), one of ACDs on duodenal microbiota during the first week of SAP with duodenal aspirates culture and 16sRNA Illumina sequencing analysis. 66 patients were randomized as 1:1 ratio into Eso group (Eso 40 mg/day) and Eso-N group (no Eso). The occurrence of duodenal bacterial overgrowth (DBO) was significantly higher in Eso group (about 85%) than that in Eso-N group (about 42%). The duodenal microbiota of the SAP patients shifted away from that of the normal control. There were differences between the Eso-N and Eso groups including enriched abundances of the class Negativicutes, order Selenomonadales and genus Veillonella. Acid suppression significantly increased incidence of Candida oesophagitis (CE) by 8-folds but did not increase other infectious events. In conclusion, acid suppression greatly increased the occurrence of DBO, duodenal dysbiosis and CE during the first week of SAP. Restrictive use of acid-suppressing medications might be helpful to reduce CE and potential risk of pancreatic infection in SAP patients.Trial registration: Chictr.org, ChiCTR-IPR-16008301, Registered April 18 2016, http://www.chictr.org.cn/showproj.aspx?proj=14089.
Apparent physical brightness of graphemes is altered by their synaesthetic colour in grapheme-colour synaesthetes
Authors: Uno Kyuto , Yokosawa Kazuhiko 
Published: November 2020

AbstractGrapheme-colour synaesthesia is a condition in which the visual perception of letters or numbers induces a specific colour sensation. In this study, we demonstrated that the apparent physical brightness of graphemes is modulated by the synaesthetic colours elicited by them. Synaesthetes first selected a synaesthetic colour corresponding to each capital letter and digit. Then, we selected a grapheme stimulus with a bright synaesthetic colour and one with a dark colour for each synaesthete. Finally, synaesthetes and non-synaesthete controls participated in a brightness judgment task, in which each participant judged the real brightness of each of the two stimuli compared to a standard stimulus. Compared to non-synaesthetes, synaesthetes judged a grapheme with a bright synaesthetic colour to be brighter than one with a dark synaesthetic colour, suggesting that the synaesthetic colour experience of synaesthetes alters their brightness perception. Such alteration in real brightness perception was observed both in those who experienced synaesthetic colours in external space (projector-type synaesthetes) and in those who experienced such colours ‘in the mind’s eye’ (associator-type synaesthetes). These results support the view that early visual processing is modulated by feedback transmitted from the V4 colour area, the neural activation of which accompanies synaesthetic colour experience.
Autonomous adaptive data acquisition for scanning hyperspectral imaging
Authors: Holman Elizabeth A. , Fang Yuan-Sheng , Chen Liang , DeWeese Michael , Holman Hoi-Ying N. , Sternberg Paul W. 
Published: November 2020

AbstractNon-invasive and label-free spectral microscopy (spectromicroscopy) techniques can provide quantitative biochemical information complementary to genomic sequencing, transcriptomic profiling, and proteomic analyses. However, spectromicroscopy techniques generate high-dimensional data; acquisition of a single spectral image can range from tens of minutes to hours, depending on the desired spatial resolution and the image size. This substantially limits the timescales of observable transient biological processes. To address this challenge and move spectromicroscopy towards efficient real-time spatiochemical imaging, we developed a grid-less autonomous adaptive sampling method. Our method substantially decreases image acquisition time while increasing sampling density in regions of steeper physico-chemical gradients. When implemented with scanning Fourier Transform infrared spectromicroscopy experiments, this grid-less adaptive sampling approach outperformed standard uniform grid sampling in a two-component chemical model system and in a complex biological sample, Caenorhabditis elegans. We quantitatively and qualitatively assess the efficiency of data acquisition using performance metrics and multivariate infrared spectral analysis, respectively.
Polarization-selective modulation of supercavity resonances originating from bound states in the continuum
Authors: Kyaw Chan , Yahiaoui Riad , Burrow Joshua A. , Tran Viet , Keelen Kyron , Sims Wesley , Red Eddie C. , Rockward Willie S. , Thomas Mikkel A. , Sarangan Andrew , Agha Imad , Searles Thomas A. 
Published: November 2020

AbstractBound states in the continuum (BICs) are widely studied for their ability to confine light, produce sharp resonances for sensing applications and serve as avenues for lasing action with topological characteristics. Primarily, the formation of BICs in periodic photonic band gap structures are driven by symmetry incompatibility; structural manipulation or variation of incidence angle from incoming light. In this work, we report two modalities for driving the formation of BICs in terahertz metasurfaces. At normal incidence, we experimentally confirm polarization driven symmetry-protected BICs by the variation of the linear polarization state of light. In addition, we demonstrate through strong coupling of two radiative modes the formation of capacitively-driven Freidrich-Wintgen BICs, exotic modes which occur in off-Γ points not accessible by symmetry-protected BICs. The capacitance-mediated strong coupling at 0° polarization is verified to have a normalized coupling strength ratio of 4.17% obtained by the Jaynes-Cummings model. Furthermore, when the polarization angle is varied from 0° to 90° (0° ≤ ϕ < 90°), the Freidrich-Wintgen BIC is modulated until it is completely switched off at 90°.
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats
Authors: Silva de Almeida Tatiane Cristine , Lanza Katharina , da Silva Filha Roberta , C. Campos Leda Maria de Castro , Fonseca Esdras G. , Chagas Mariana W. , Rocha Natalia Pessoa , de Sá Marcos Augusto , Vieira Maria Aparecida Ribeiro , Caliari Marcelo Vidigal , Kangussu Lucas M. , Ferreira Anderson José , Simões e Silva Ana Cristina 
Published: November 2020

Abstract
Acute Kidney Injury (AKI) comprises a rapidly developed renal failure and is associated with high mortality rates. The Renin–Angiotensin System (RAS) plays a pivotal role in AKI, as the over-active RAS axis exerts major deleterious effects in disease progression. In this sense, the conversion of Angiotensin II (Ang II) into Angiotensin-(1-7) (Ang-(1-7)) by the Angiotensin-converting enzyme 2 (ACE2) is of utmost importance to prevent worse clinical outcomes. Previous studies reported the beneficial effects of oral diminazene aceturate (DIZE) administration, an ACE2 activator, in renal diseases models. In the present study, we aimed to evaluate the therapeutic effects of DIZE administration in experimental AKI induced by gentamicin (GM) in rats. Our findings showed that treatment with DIZE improved renal function and tissue damage by increasing Ang-(1-7) and ACE2 activity, and reducing TNF-α. These results corroborate with a raising potential of ACE2 activation as a strategy for treating AKI.
Evolution of galaxy scaling relations in clusters at 0.5 <z< 1.5
Authors: Pérez-Martínez J. M. , Ziegler B. , Dannerbauer H. , Böhm A. , Verdugo M. , Díaz A. I. , Hoyos C. 
Published: November 2020

Aims.We present new gas kinematic observations with the OSIRIS instrument at the GTC for galaxies in the Cl1604 cluster system atz ∼ 0.9. These observations together with a collection of other cluster samples at different epochs analyzed by our group are used to study the evolution of the Tully-Fisher, velocity-size, and specific angular momentum-stellar mass relations in dense environments over cosmic time.Methods.We used 2D and 3D spectroscopy to analyze the kinematics of our cluster galaxies and extract their maximum rotation velocities (Vmax), which were used as the common parameter in all scaling relations under scrutiny. We determined the structural parameters of our objects by fitting surface brightness profiles to the images of our objects, while stellar-mass values were computed by fitting the spectral energy distribution by making use of extensive archival optical to near-IR photometry. Our methods were consistently applied to all our cluster samples. This makes them ideal for an evolutionary comparison.Results.Up to redshift one, our cluster samples show evolutionary trends compatible with previous observational results in the field and in accordance with semianalytical models and hydrodynamical simulations concerning the Tully-Fisher and velocity-size relations. However, we find a drop of a factor ∼3 in disk sizes and an averageB-band luminosity enhancement ⟨ΔMB⟩∼2 mag byz ∼ 1.5. We discuss the role that different cluster-specific interactions may play in producing this observational result. In addition, we find that our intermediate-to-high redshift cluster galaxies follow parallel sequences with respect to the local specific angular momentum to stellar mass relation, although they display lower specific angular momentum values than field samples at similar redshifts. This may be explained by the stronger interacting nature of dense environments in comparison with the field.
Endoscopic ultrasound-guided radiofrequency ablation of pancreatic neuroendocrine tumors: a systematic review of the literature
Authors: Imperatore Nicola , de Nucci Germana , Mandelli Enzo Domenico , de Leone Annalisa , Zito Francesco Paolo , Lombardi Giovanni , Manes Gianpiero 
Published: November 2020

Abstract
Background and study aims Surgery is the mainstay therapy for pancreatic neuroendocrine tumors (P-NETs), but it is associated with significant adverse events (AEs). In recent years, endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has been described for treating P-NETs. We performed a systematic literature review aimed at exploring the feasibility, effectiveness, and safety of EUS-RFA in treatment of P-NETs.
Methods The literature review was performed in PubMed/MEDLINE, EMBASE, and SCOPUS to identify all case reports of EUS-RFA for treatment of P-NETs.
Results Sixyt-one patients (males 49.2 %, mean age 64.5 years) and 73 tumors (mean size 16 mm, insulinomas 30.1 %) treated with EUS-RFA were included from 12 studies. The overall effectiveness of EUS-RFA was 96 % (75 % – 100 %) without differences between functional vs. non-functional P-NETs (P = 0.3) and without relevant issues about safety (mild AEs 13.7 %). While tumor location was not predictive for incomplete/non-response to EUS-RFA, greater tumor dimensions predicted treatment failure (21.8 ± 4.71 mm in the non-response group vs 15.07 ± 7.34 mm in the response group, P = 0.048). At ROC analysis, a P-NET size cut-off value ≤18 mm predicted response to treatment, with a sensitivity of 80 % (95 % CI 28.4 % – 99.5 %), a specificity of 78.6 % (95 % CI 63.2 % – 89.7 %), a positive predictive value of 97.1 % (95 % CI 84.7 % – 99.9 %) and a negative predictive value of 30.8 % (95 % CI 9.1 % – 61.4 %), with an area under the curve of 0.81 (95 % CI 0.67 – 0.95).
Conclusions EUS-RFA is safe and effective for treating P-NETs. It may be reasonable to consider EUS-RFA for small P-NETs, irrespective of the functional status.
Duodenoscope-associated infection prevention: A call for evidence-based decision making
Authors: Ofstead Cori L. , Buro Brandy L. , Hopkins Krystina M. , Eiland John E. , Wetzler Harry P. , Lichtenstein David R. 
Published: November 2020

Abstract
Background Recent outbreaks of duodenoscope-associated multidrug-resistant organisms (MDROs) have brought attention to the infection risk from procedures performed with duodenoscopes. Prior to these MDRO outbreaks, procedures with duodenoscopes were considered safe and low risk for exogenous infection transmission, provided they were performed in strict accordance with manufacturer instructions for use and multisociety reprocessing guidelines. The attention and efforts of the scientific community, regulatory agencies, and the device industry have deepened our understanding of factors responsible for suboptimal outcomes. These include instrument design, reprocessing practices, and surveillance strategies for detecting patient and instrument colonization. Various investigations have made it clear that current reprocessing methods fail to consistently deliver a pathogen-free instrument. The magnitude of infection transmission has been underreported due to several factors. These include the types of organisms responsible for infection, clinical signs presenting in sites distant from ERCP inoculation, and long latency from the time of acquisition to infection. Healthcare providers remain hampered by the ill-defined infectious risk innate to the current instrument design, contradictory information and guidance, and limited evidence-based interventions or reprocessing modifications that reduce risk. Therefore, the objectives of this narrative review included identifying outbreaks described in the peer-reviewed literature and comparing the findings with infections reported elsewhere. Search strategies included accessing peer-reviewed articles, governmental databases, abstracts for scientific conferences, and media reports describing outbreaks. This review summarizes current knowledge, highlights gaps in traditional sources of evidence, and explores opportunities to improve our understanding of actual risk and evidence-based approaches to mitigate risk.
Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients
Authors: Kousgaard Sabrina Just , Gade Michael , Petersen Lars Jelstrup , Thorlacius-Ussing Ole 
Published: November 2020

Abstract
Background and study aims Further diagnostics of incidental colorectal lesions on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is questionable. Therefore, we aimed to evaluate the clinical importance of incidentally detected colorectal lesions on FDG-PET/CT.
Patients and methods In the North Denmark Region, a retrospective study was performed among 19,987 patients who had an FDG-PET/CT from January 2006 to December 2015. Among these patients, we identified patients with a colonoscopy within 12 months from the PET/CT scan and a description of incidental colorectal PET-avid lesions on the PET/CT. PET findings were compared with colonoscopy-detected lesions and eventually histopathology.
Results Incidental PET-avid lesions were observed in 549 patients. Colonoscopy revealed lesions in 457 (83 %), among whom 338 patients had a final histopathological diagnosis. Malignant and premalignant lesions were found in 297 patients (54 % among patients with a PET-avid lesion). The lesions were cancer in 76 patients and adenoma in 221 patients of whom 30 had high-grade and 191 low-grade adenomas. The findings changed patient management in 166 cases (30 % of all patients with a PET-avid lesion). A colonoscopy-based surveillance program was initiated for 80 % of patients with high-grade adenoma. No patients with PET-avid lesions but normal colonoscopy developed colorectal cancer during 3 years of observation (median observation time 7 years).
Conclusions Incidental colorectal FDG uptake was infrequently observed, but when present, it was associated with a high rate of malignant or premalignant lesions. Our results indicate that patients with incidental colorectal FDG uptake should be referred to diagnostic work-up including colonoscopy.
Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders
Authors: Fujiwara Yasuhiro , Tanoue Kojiro , Higashimori Akira , Nishida Yu , Maruyama Masatsugu , Itani Shigehiro , Ominami Masaki , Nadatani Yuji , Fukunaga Shusei , Otani Koji , Hosomi Shuhei , Tanaka Fumio , Kamata Noriko , Nagami Yasuaki , Taira Koichi , Machida Hirohisa , Tanigawa Tetsuya , Watanabe Toshio , Ohsawa Masahiko ,   F-Study group
Published: November 2020

Abstract
Background and study aims Eosinophilic gastrointestinal disorders are classified into eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis according to the site of eosinophilic infiltration. Although well established in eosinophilic esophagitis, endoscopic findings in eosinophilic gastritis and eosinophilic gastroenteritis with regard to gastric lesions have not been clearly described. The aim of this study was to identify endoscopic findings of gastric lesions associated with eosinophilic gastrointestinal disorders.
Patients and methods Out of 278 patients with eosinophilic gastrointestinal disorders, 18 had eosinophilic gastritis or eosinophilic gastroenteritis confirmed by biopsy; their endoscopic images were analyzed retrospectively. The association between endoscopic findings and number of eosinophils in the gastric mucosa was investigated.
Results Erythema was most frequently observed (72 %), followed by ulcers (39 %), discoloration (33 %), erosions (28 %), nodularity (28 %), and polyps (28 %). There were several unique endoscopic findings such as submucosal tumor-like deep large ulcers in three patients, antral Penthorum-like appearances (small nodules radially lined toward the pyloric ring) in three patients, “muskmelon-like appearances” (discolored mucosa-composed mesh pattern) in three patients, multiple white granular elevations in two patients, cracks (appearance of furrows similar to those in eosinophilic esophagitis) in five patients, and antral rings in one patient. No significant association was observed between endoscopic findings and number of gastric eosinophils.
Conclusions Several unique endoscopic findings of gastric lesions were observed in patients with eosinophilic gastritis or eosinophilic gastroenteritis. Submucosal tumor-like ulcers, antral Penthorum-like appearances, muskmelon-like appearances, and cracks might be associated with eosinophilic gastrointestinal disorders.