bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct microbial signatures and their predictive value in recurrent acute pancreatitis: insights from 5-region 16S rRNA gene sequencing
Authors: Wang Qi-Wen , Zheng Haorui , Yang Yang , Chang Xinyao , Du Zengkan , Hang Zi-ning , Li Zhao-Shen , Liao Zhuan 
Published: February 2025

BackgroundRecurrent acute pancreatitis (RAP) poses significant clinical challenges, with 32.3% developing to chronic pancreatitis within 5 years. The underlying microbial factors contributing to RAP remain poorly understood. This study aims to identify blood microbial signatures associated with RAP and explore the potential microbial predictors for RAP.MethodsIn this prospective cohort, 90 acute pancreatitis patients are classified into non-recurrent acute pancreatitis (NRAP, n=68) and RAP (n=22) groups based on the number of pancreatitis episodes. Microbial composition of blood samples is analyzed using 5-region (5R) 16S rRNA gene sequencing. Key microbial taxa and functional predictions are made. A random forest model is used to assess the predictive value of microbial features for RAP. The impact of Staphylococcus hominis (S. hominis) on RAP is further evaluated in an experimental mouse model.ResultsLinear discriminant analysis effect size (LEfSe) analysis highlights significant microbial differences, with Paracoccus aminovorans, Corynebacterium glucuronolyticum and S. hominis being prominent in RAP. Functional predictions indicate enrichment of metabolic pathways in the RAP group. Random forest analysis identifies key microbial taxa with an AUC value of 0.759 for predicting RAP. Experimental validation shows that S. hominis exacerbates pancreatic inflammation in mice.ConclusionsThis study identifies distinct clinical and microbial features associated with RAP, emphasizing the role of specific bacterial taxa in pancreatitis recurrence. The findings suggest that microbial profiling could enhance the diagnosis and management of RAP, paving the way for personalized therapeutic approaches.
Naegeli-Franceschetti-Jadassohn syndrome: a systematic review of case studies
Authors: Shah Hussain Haider , Hussain Tooba , Subash Arun , Qadir Ramsha Abdul , Meshram Yashika Rajesh , Shahzad Maryam , Sultan Wania , Hadi Zeenat , Ashfaque Faiza , Anas Zahra , Rauf Sameer Abdul , Waseem Radeyah , Hussain Muhammad Sheheryar , Zuberi Muhammad Abdul Wasay 
Published: February 2025

IntroductionNaegeli-Franceschetti-Jadassohn syndrome (NFJS), also known as Naegeli Syndrome, is a rare autosomal dominant ectodermal dysplasia characterized by mutations in the KRT14 gene. These mutations disrupt ectodermal tissue development, leading to diverse clinical manifestations involving the skin, nails, teeth, and sweat glands.MethodologyA systematic search across PubMed, Google Scholar, European PMC, and Cochrane databases was conducted up to August 2023. Only case reports, case series, and original articles reporting cases were included.ResultsThis review incorporated 6 case reports, 2 case series, 3 original articles, and 1 editorials, encompassing 33 individuals diagnosed with NFJS. Key clinical features included extensive reticulate hyperpigmentation, palmoplantar keratoderma, and dental anomalies. Rarely reported findings, such as cerebellar fissures and generalized osteopenia, were noted in two cases. Treatment predominantly focused on symptomatic management using topical emollients and antioxidants.ConclusionNFJS remains a diagnostic challenge due to its rarity and overlap with other pigmentary disorders. This review consolidates current knowledge to aid clinicians in recognizing and managing NFJS. Further research is needed to clarify its pathogenesis and explore targeted treatments.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447267, identifier CRD42023447267.
Impact of interferon-β and dimethyl fumarate on nonlinear dynamical characteristics of electroencephalogram signatures in patients with multiple sclerosis
Authors: Hernandez Christopher Ivan , Afek Natalia , Gawłowska Magda , Oświęcimka Paweł , Fafrowicz Magdalena , Slowik Agnieszka , Wnuk Marcin , Marona Monika , Nowak Klaudia , Zur-Wyrozumska Kamila , Amon Mary Jean , Hancock P. A. , Marek Tadeusz , Karwowski Waldemar 
Published: February 2025

IntroductionMultiple sclerosis (MS) is an intricate neurological condition that affects many individuals worldwide, and there is a considerable amount of research into understanding the pathology and treatment development. Nonlinear analysis has been increasingly utilized in analyzing electroencephalography (EEG) signals from patients with various neurological disorders, including MS, and it has been proven to be an effective tool for comprehending the complex nature exhibited by the brain.MethodsThis study seeks to investigate the impact of Interferon-β (IFN-β) and dimethyl fumarate (DMF) on MS patients using sample entropy (SampEn) and Higuchi’s fractal dimension (HFD) on collected EEG signals. The data were collected at Jagiellonian University in Krakow, Poland. In this study, a total of 175 subjects were included across the groups: IFN-β (n = 39), DMF (n = 53), and healthy controls (n = 83).ResultsThe analysis indicated that each treatment group exhibited more complex EEG signals than the control group. SampEn had demonstrated significant sensitivity to the effects of each treatment compared to HFD, while HFD showed more sensitivity to changes over time, particularly in the DMF group.DiscussionThese findings enhance our understanding of the complex nature of MS, support treatment development, and demonstrate the effectiveness of nonlinear analysis methods.
Postnatal counseling promotes early initiation and exclusive breastfeeding: a randomized controlled trial
Authors: Beyene Belda Negesa , Wako Wako Golicha , Moti Dureti , Edin Alo , Debela Derese Eshetu 
Published: February 2025

BackgroundBreastfeeding plays a crucial role in promoting the health and wellbeing of both mothers and their infants, contributing to healthier populations and reducing long-term healthcare costs. Encouraging breastfeeding through education, support, and policies is essential for maximizing these benefits. The purpose of this study was to evaluate the impact of immediate postpartum counseling on early initiation of breastfeeding rates and exclusive breastfeeding in Bule Hora Teaching and Yabelo General Hospitals.MethodsA cluster randomized single-blinded trial was conducted on 224 postpartum women (112 in the intervention group and 112 in the control group) from January 1, 2023, to May 30, 2023. The effects of immediate postpartum counseling and its associated variables on early initiation and exclusive breastfeeding practices were evaluated using logistic regressions. A p-value of less than 0.05, a 95% confidence interval, and an adjusted odds ratio were used to determine statistical significance.ResultsThe proportion of early initiation of breastfeeding was significantly greater in the intervention group than in the control group (54.1% vs. 45.9%, p = 0.001), and exclusive breastfeeding practice were also significantly greater among women who received immediate breastfeeding counseling than among those who did not receive it (61.9% vs. 38.1%, p = 0.015). Those mothers who had an ANC visit for their pregnancy were three times more likely (AOR = 3.01, 95% CI = 1.12–8.1) to initiate breastfeeding. Having good knowledge regarding breastfeeding made them six times more likely to initiate breast-feeding earlier (AOR = 6.18, 95% CI = 1.77–21.57). Women who received counseling (AOR = 3.36, 95% CI: 1.83–6.16) and women who had good knowledge about breastfeeding (AOR = 1.88, 95% CI: 1.01–3.49) were significantly associated with exclusive breastfeeding practices.ConclusionThis study revealed that immediate postpartum breastfeeding counseling can positively influence both early initiations of breastfeeding and exclusive breastfeeding practices. Providing sustained education to women regarding early initiation and exclusive breastfeeding practices should be strengthened.
Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001–2018
Authors: Duan Yang , Yang Ke , Zhang Tianai , Guo Xiangsheng , Yin Qianran , Liu He 
Published: February 2025

ObjectiveThis research is to analyze the connection between NHHR and CKD occurrence using NHANES from 2001 to 2018. It will evaluate the feasibility of NHHR as a tool for predicting CKM syndrome and offer valuable insights for personalized treatment approaches within the U.S. population.MethodsData from 16,575 individuals aged 20 to 69 years were analyzed, having excluded those who were pregnant and individuals with incomplete data. CKM syndrome was characterized by the simultaneous presence of CKD and Cardiometabolic Syndrome (CMS). For the statistical analysis, weighted logistic regression models were applied, accounting for variables such as age, gender, ethnicity, educational background, marital status, lifestyle factors, and preexisting health conditions. Differently, restricted cubic splines (RCS) were applied to investigate any possible nonlinear relationships between NHHR and CKM in the study.ResultsThe research revealed that the occurrence of CKM syndrome was more prevalent among individuals aged 60 and older, with women representing 55.36% of those affected. Additionally, NHHR levels were notably elevated in CKM patients when compared to those without CKM (p &lt; 0.0001). As NHHR increased, the prevalence of CKM also rose, with the highest prevalence in the highest NHHR quartile (Q4: 36.06%). A positive connection between NHHR and CKM was indicated by multivariable logistic regression, especially in the upper quartiles of NHHR (Q3 and Q4). Moreover, RCS analysis displayed a noteworthy nonlinear connection between NHHR and CKM occurrence. The subgroup analysis uncovered significant interactions influenced by BMI and Hypertension.ConclusionWith the rising global prevalence of CKM syndrome, early identification of high-risk individuals using NHHR could inform targeted prevention and intervention strategies. Future research should focus on validating NHHR in diverse populations and exploring its clinical utility, as well as examining its relationship with other biomarkers of metabolic dysfunction to better understand CKM syndrome’s complex pathophysiology.
Association between METS-IR and female infertility: a cross-sectional study of NHANES 2013–2018
Authors: Li Haiyan , Tan Hongxia , OuYang Zhenbo , Hu Xianyue , Bao Yanjing , Gao Tianyang , Hua Wenfeng 
Published: February 2025

BackgroundObesity and metabolic syndrome are significant contributors to infertility in women and are closely associated with insulin resistance (IR). The metabolic score for insulin resistance (METS-IR) is a new, non-insulin-based fasting index used to measure IR. However, the potential of METS-IR as a predictive indicator of female infertility risk has not been established. This study aimed to explore the association between METS-IR and the risk of female infertility.MethodsThis cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. We conducted multivariate logistic regression, restricted cubic spline (RCS), and threshold effect analyses to investigate the relationship between METS-IR and female infertility.ResultsAccording to the self-reported data, 188 (12.20%) participants were classified as infertile. A significantly higher proportion of participants with elevated METS-IR were found to have infertility. Multivariable logistic regression analysis revealed that METS-IR was significantly associated with increased risk of female infertility, irrespective of the independent variable analysis by continuous variables or tertiles in the fully adjusted model (Model 3, continuous variable: OR = 1.02, 95% confidence interval (CI):1.01–1.04, p = 0.005; tertile 3 vs. tertile 1: OR = 2.00, 95% CI = 1.21–3.28, p = 0.0128, p for trend =0.0126). RCS analysis indicated a linear correlation between METS-IR and the risk of infertility (p = 0.121), and threshold effect analysis further supported this linear association (p = 0.136). Moreover, above the inflection point of 32.94, the risk of infertility significantly increased with increasing METS-IR level (p &lt; 0.0001).ConclusionOur results suggest that high levels of the METS-IR index are positively associated with infertility among reproductive-aged females in the United States.
A comparative analysis of survival outcomes and adverse effects between preoperative brachytherapy with radical surgery and concurrent chemoradiotherapy in patients with locally advanced cervical cancer
Authors: Niu Yuna , Du Chengchao , Zhou Yeqin , Zhang Miao , Guo Qi , Zhou Honggui 
Published: February 2025

BackgroundTo compare the long-term efficacy and adverse effects of preoperative brachytherapy combined with radical surgery versus concurrent chemoradiotherapy (CCRT) in patients with locally advanced cervical cancer (LACC).MethodsThis retrospective study analyzed 161 patients with LACC treated at the Affiliated Hospital of North Sichuan Medical College between January 2015 and December 2020. Of these, 76 patients underwent preoperative brachytherapy combined with radical surgery (study group), while 85 received CCRT (control group). After propensity score matching (PSM) to minimize confounding, 124 patients (62 per group) were included in the analysis. Survival outcomes and prognostic factors were evaluated using Kaplan-Meier survival analysis and Cox regression models. Adverse effects of treatment were compared between the groups.ResultsAfter PSM, the 5-year progression-free survival (PFS) rate in the study group was significantly higher than that in the control group (81.2% vs. 62.7%, P&lt;0.05). There was no significant between-group difference regarding the 5-year overall survival (OS) rate (81.4% vs. 74.9%, P=0.41). Multivariate analysis identified treatment modality (preoperative brachytherapy combined with radical surgery vs. CCRT) as an independent prognostic factor for PFS (HR: 0.458, 95% CI 0.221–0.945, P=0.035). The study group had significantly lower rates of grade 2 acute radiation enteritis, grade 3-4 leukopenia, and anemia compared to the control group (P&lt;0.05), with no significant differences observed in other adverse effects (P&gt;0.05).ConclusionPreoperative brachytherapy combined with radical surgery may help improve the PFS of patients with LACC, with fewer adverse effects, making it a potentially viable treatment option for these patients.
Case Report and review of the literature: esophageal pleomorphic rhabdomyosarcoma
Authors: Pittacolo Matteo , Vittori Arianna , Moletta Lucia , Zanchettin Gianpietro , Pierobon Elisa Sefora , Capovilla Giovanni , Salvador Renato , Michelotto Mauro , Valmasoni Michele 
Published: February 2025

BackgroundEsophageal rhabdomyosarcoma is an exceedingly rare malignant tumor, with only three cases comprehensively documented in the literature since 1995. Due to its rarity, there is limited information on the epidemiology and diagnosis of this disease, and no standardized treatment protocols have been established. As a result, both the recognition and management of esophageal rhabdomyosarcoma pose significant challenges. The present case report provides valuable insight into the clinical approach to this rare tumor, highlighting the need for further research and investigation to develop more effective diagnostic tools and therapeutic strategies.Case PresentationWe described the case of a 77-year-old male who presented with dyspepsia and anemia, leading to the discovery of an esophageal lesion. At the index endoscopy, histological findings were consistent with esophageal adenocarcinoma. Consequently, the patient was treated with neoadjuvant chemotherapy and Ivor Lewis esophagectomy. Interestingly, on pathological examination the lesion was identified as a pleomorphic rhabdomyosarcoma of the esophagus. Postoperatively, the patient received adjuvant chemotherapy. Subsequently, a subcutaneous metastatic lesion on his right shoulder was treated with a combination of radiotherapy and surgical excision. The patients died twenty-six months after the initial diagnosis.ConclusionsOur case represents one of the few reported instances of esophageal rhabdomyosarcoma, a highly rare and aggressive malignancy, and provides valuable insights into the challenges of diagnosing and managing this disease. Moreover, this is one of the first cases of esophageal rhabdomyosarcoma followed up for more than 24 months. However, given the paucity of data on esophageal rhabdomyosarcoma, there remains a significant unmet need for more comprehensive studies to establish standardized diagnostic and therapeutic protocols.
Identification of subgroups of early-stage mycosis fungoides patients with increased itch and impaired quality of life
Authors: Nenonen Julia , Winther Anna H. , Jonsson Pontus , Ivert Lina U. , Brauner Hanna 
Published: February 2025

IntroductionMycosis fungoides (MF), Sézary syndrome (SS) and other cutaneous T-cell lymphomas (CTCLs) can have a severe impact on quality of life (QoL) and itch, but early MF is insufficiently investigated despite representing most patients. This single center study investigated associations between QoL/itch/depressive symptoms and clinical phenotypes in patients with CTCL with particular focus on early MF-stages.MethodsPatients were included during routine dermatological care. The primary outcomes included Dermatology Life Quality Index (DLQI), EuroQoL 5D (EQ-5D) index, Montgomery-Åsberg Depression Rating Scale – Self report (MADRS-S), and itch measured with a visual analogue scale (VAS-itch).ResultsIn the total CTCL cohort (n=76), median EQ-5D index was impaired in female vs male patients (0.73 vs 0.85, p = 0.040). Among early MF patients (n=58), increased disease activity correlated with impaired DLQI (r = 0.413, p = 0.0014) and EQ-5D index (r = -0.317, p = 0.0161). Early MF patients with plaques vs only patches reported impaired EQ-5D index (median 0.725 vs 0.848, p = 0.0032) and increased itch (median VAS 3.27 vs 0.43, p = 0.0006). MF patients with stage IB vs IA reported impaired DLQI (median 5.00 vs 1.00, p = 0.0006), impaired EQ-5D index (median 0.725 vs 0.848, p = 0.0040) and increased itch (median VAS 3.37 vs 0.54, p = 0.0487).DiscussionAlthough early MF patients reported generally a mild impact on QoL, this study highlights the need for disease management optimization for subgroups of early MF patients, including those with plaques, stage IB and higher disease activity.
Inconclusive effects between executive functions and symptoms of psychiatric disorders in random-intercept cross-lagged panel models: a simulated reanalysis and comment on Halse et al. (2022)
Authors: Sorjonen Kimmo , Melin Bo 
Published: February 2025

BackgroundIn a recent study of Norwegian children (N = 874), Halse et al. used random-intercept cross-lagged panel models (RI-CLPM) and concluded that their findings supported the assumption that deficiencies in executive functions and psychopathology are both a cause and a consequence of the other. However, it is known that RI-CLPM can give biased results.MethodsWe reanalyzed data simulated to resemble the data used by Halse et al. with several complementary models, e.g., latent change score models (LCSM).ResultsThe analyzed models indicated contradictory simultaneous increasing and decreasing effects between executive deficits and symptoms of psychopathology.ConclusionThe present contradictory findings suggested that prospective effects between executive deficits and symptoms of psychopathology may have been spurious rather than truly increasing. Consequently, conclusions by Halse et al. appear to have been premature. It is important for researchers to bear in mind that correlations, including cross-lagged effects in RI-CLPM, do not prove causality. Careful interpretation of RI-CLPM results is of utmost importance in, for example, research in clinical and developmental psychology. We recommend researchers to use, as we did here, triangulation to scrutinize findings from analyses of observational data.
The hierarchical framework of wellbeing (HiFWB)
Authors: Disabato David J. , Goodman Fallon R. , Kashdan Todd B. 
Published: February 2025

PurposeSeveral decades of research on wellbeing has resulted in a variety of conceptual models used to measure wellbeing. The historical motivations behind these conceptual models have emphasized their differences to the point of clouding the wellbeing measurement landscape. A synthesis of the wellbeing literature is needed to move the field forward and guide future research.MethodsIn this review, we synthesize literature on the measurement of wellbeing from the past 50 years and present The Hierarchical Framework of Wellbeing (HiFWB) that organizes multiple prior models.ResultsWe propose a general factor of wellbeing (i.e., “h” factor) at the top level of the hierarchy analogous to “g” in the intelligence literature and “p” in the psychopathology literature. Building off prior conceptualizations, we define general well-being as “the experience of personally valued fulfillment within one's life.” We detail the theoretical rationale and empirical evidence behind four hierarchical levels: general (i.e., “h” factor), lenses (e.g., subjective wellbeing), contents (e.g., affects), and characteristics (e.g., positive affect). Example wellbeing constructs are proposed for each level of HiFWB while emphasizing the hierarchical structure is prioritized above any (arbitrary) list of constructs. We discuss various approaches to distinguishing predictors of wellbeing from wellbeing itself (i.e., preventing tautologies) and how they fit into our framework. Considering the bulk of the empirical evidence comes from Western, Educated, Industrialized, Rich, Democratic (WEIRD) cultures, constraints on generalizability are important. Throughout, we compare and contrast HiFWB to other hierarchical structures in psychological science (e.g., five factor model of personality).ConclusionThe HiFWB is a flexible, encompassing, evidence-based framework for wellbeing conceptualization and measurement in WEIRD populations.