bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies related the measurement errors determination in case of inclined surfaces measurement on Coordinate Measurement Machines
Authors: Serban P E , Peti F 
Published: August 2020

Abstract
Coordinate measurement machines (CMM) are an important part of production process technology that help and give a fast response in complex measurement situations. Although the technologies advance in high speed, old coordinate measurement machines are capable to give accurate results. The present paper will give an alternative to use this type of machines, machines that are operated manual or with rudimental software that are not upgraded with actual technologies. In order to be possible to measure an inclined surface with a coordinate measurement machine we need to consider that the contact approach between the coordinate measurement machine tool and the measured part must respect some elementary steps: the movement of the coordinate measurement machine probe must be on same direction as the surface vector that we want to measure, the contact force must be the same as the force used for calibration of the probe. All this are very difficult to be respected with a manual or oldcoordinate measurement machine. During measurement with machines that doesn’t allow probe angle control an error can appear for surfaces that are positioned at an angle to the reference surface. This article presents one way to can eliminate measurement errors on Coordinate measurementmachines for inclined surfaces.
Custom vacuum load-lock for the sputtering vacuum chamber, loading/unloading and locking automatisation mechanisms
Authors: Țarcá D.I. , Costea T. , Moga I. 
Published: August 2020

Abstract
This paper presents the continuity of my work presented in previous articles regarding my activity as a PhD student at the University of Oradea, Doctoral School of Industrial Engineering. After installing, cleaning, vacuum testing and developing an experimental system for vacuum measurement, we decided that the next best step would be to develop the system with a load-lock further, as the time required for experiments would drastically improve and the need for refurbishing the old positioning mechanism would be eliminated. The paper describes the steps taken, starting with CAD representing the sputtering vacuum chamber for the manufacturer to start their production process, and finalising with automating the whole start/stop and reload sequence for the load-lock with an experimental setup made from readily available equipment in our laboratory, as the initial sequences were manually only and the risk of misusing for non-trained personnel would be high.
Quick response manufacturing as a promising alternative manufacturing paradigm
Authors: Gromova E A 
Published: August 2020

Abstract
The fourth industrial revolution initiates a change in the strategic guidelines of industrial enterprises. The rapid trend towards a wide variety of finished products with a short development and production time has led to a number of problems for enterprises with inventory, overhead and efficiency. The imperative of implementing lean production is becoming irrelevant due to new challenges in the external environment and is giving way to more competitive paradigms. Now the modern production concept should be focused not only on the cost and quality of goods, but also on the speed of response and flexibility. Quick response manufacturing (QRM) is one of them, which is a corporate strategy to reduce time of execution of the order at the industrial enterprise. And it is an extremely new and unfamiliar management paradigm in Russia. The purpose of this study is to analyze quick response manufacturing and to relate it to the current state of the Russian industrial development. Theoretical and practical aspects of this concept are given. The examples of the quick response manufacturing implementation in the Russian industrial sector are presented. Summarizing, QRM is offered as a promising manufacturing paradigm for Russian industry.
Designing and validating the questionnaire used to measure the attitude of students towards e-Learning
Authors: Zlatkovic D , Ilic M , Denic N , Jovkovic S 
Published: August 2020

Abstract
Over the past two decades, numerous studies have been conducted to analyze the achievements of e-Learning; among other things, user’s of information and communication technology (ICT) skills, Internet access and attitude of students towards e-Learning. The majority of studies examine the attitude by establishing the purpose and frequency of computer use, while some measure students’ attitudes using a questionnaire without determining the measuring properties of the questionnaire. For this reason, the goal of this paper is to create a questionnaire used to measure the attitudes of students towards e-Learning and to determine its psychometric properties.
The influence of innovation onto the logistics process of goods transport by air
Authors: Milošević N , Mišić M , Denić N 
Published: August 2020

Abstract
The logistics of air transport assumes the usage of the airplane and airport warehouse capacities to transport goods from one point to another. Within this paper the process of goods manipulation is explained by using air transport and innovations introduced by various companies have been presented. The modern transport market faces the companies with numerous challenges which these companies wish to address in an adequate manner. By innovating, the companies express their constant tendency to increase the competitive advantage by improving the efficiency and effectiveness of their business processes. The number of innovations is multiple and they exist in every area of air transport. The innovations mostly appear based on the company initiative, but can also be generated by state entities, as well as national and international institutions and associations.
Investigating the effect of orientation, infill density with Triple raster pattern on the tensile properties for 3D Printed samples
Authors: Kannan Sridharan , Vezhavendhan R , Kishore Shirish , Kanumuru Kamal Varma 
Published: August 2020

Abstract
The main objective of this study is to characterize the effect of infill percentage, printing orientation and raster angle on ABS samples prepared with 3D printing technology. In this research, samples used were fabricated with two different infill percentages (50% & 75%), 6 different raster patterns and three different orientations. The influence of these parameters on tensile properties were studied with the help of 3D printed samples as per ASTM standard D638 Type IV. From the experimental analysis it was found that the tensile properties were highly anisotropic. Stress strain graphs are plotted for all the samples and the variation of strength with respect to the three parameters are analysed. It was observed that Infill density is directly proportional to mechanical properties. Flat and vertical orientation have better strength and stiffness in comparison with vertical build. The experimental results proved that flat oriented samples exhibited variable strength for changes in raster orientation, other samples have shown minimal changes only.
Monitor unit calculation in electron therapy using Monte Carlo Simulation: a GUI for the phase-space field trimming
Authors: Sivayogan Thuvatahan , Chow James C L 
Published: August 2020

Abstract

Purpose: We developed a graphical user interface (GUI) for electron phase-space field trimming using Monte Carlo simulations. This GUI can be used for monitor unit (MU) calculation in electron therapy. Methods: The GUI and electron field trimming algorithm were developed using MATLAB and C code. Phase-space files for the electron fields were generated using the EGSnrc code based on a Varian 21EX Linac with variables of applicator size, field size and energy. Verification of the alogrithm was carried out by comparing the relative output factor, which was used for MU calculation, predicted by Monte Carlo simulations and from actual measurements. Results: Our electron field trimming algorithm was found to be about five times faster than the original Monte Carlo simulation. Clinically, the GUI performed best when using voxel size ≥ 0.3 × 0.3 × 0.3 cm3, and field size larger than 2 cm in radius based on an acceptable deviation of 2%. Conclusion: A GUI for generating irregular field for MU calculation using Monte Carlo simulations was created as a user-friendly tool in electron therapy.
Heat wave effects on the behavior and life-history traits of sedentary antlions
Authors: Miler Krzysztof , Stec Daniel , Czarnoleski Marcin 
Published: August 2020

Abstract
Research on the behavioral responses of animals to extreme weather events, such as heat wave, is lacking even though their frequency and intensity in nature are increasing. Here, we investigated the behavioral response to a simulated heat wave in two species of antlions (Neuroptera: Myrmeleontidae). These insects spend the majority of their lives as larvae and live in sandy areas suitable for a trap-building hunting strategy. We used larvae of Myrmeleon bore and Euroleon nostras, which are characterized by different microhabitat preferences—sunlit in the case of M. bore and shaded in the case of E. nostras. Larvae were exposed to fluctuating temperatures (40 °C for 10 h daily and 25 °C for the remaining time) or a constant temperature (25 °C) for an entire week. We found increased mortality of larvae under heat. We detected a reduction in the hunting activity of larvae under heat, which corresponded to changes in the body mass of individuals. Furthermore, we found long-term consequences of the simulated heat wave, as it prolonged the time larvae needed to molt. These effects were pronounced in the case of E. nostras but did not occur or were less pronounced in the case of M. bore, suggesting that microhabitat-specific selective pressures dictate how well antlions handle heat waves. We, thus, present results demonstrating the connection between behavior and the subsequent changes to fitness-relevant traits in the context of a simulated heat wave. These results illustrate how even closely related species may react differently to the same event.
OGRE: Overlap Graph-based metagenomic Read clustEring
Authors: Balvert Marleen , Luo Xiao , Hauptfeld Ernestina , Schönhuth Alexander , Dutilh Bas E 
Published: August 2020

Abstract

Motivation
The microbes that live in an environment can be identified from the combined genomic material, also referred to as the metagenome. Sequencing a metagenome can result in large volumes of sequencing reads. A promising approach to reduce the size of metagenomic datasets is by clustering reads into groups based on their overlaps. Clustering reads are valuable to facilitate downstream analyses, including computationally intensive strain-aware assembly. As current read clustering approaches cannot handle the large datasets arising from high-throughput metagenome sequencing, a novel read clustering approach is needed. In this article, we propose OGRE, an Overlap Graph-based Read clustEring procedure for high-throughput sequencing data, with a focus on shotgun metagenomes.

Results
We show that for small datasets OGRE outperforms other read binners in terms of the number of species included in a cluster, also referred to as cluster purity, and the fraction of all reads that is placed in one of the clusters. Furthermore, OGRE is able to process metagenomic datasets that are too large for other read binners into clusters with high cluster purity.

Conclusion
OGRE is the only method that can successfully cluster reads in species-specific clusters for large metagenomic datasets without running into computation time- or memory issues.

Availabilityand implementation
Code is made available on Github (https://github.com/Marleen1/OGRE).

Supplementary information
Supplementary data are available at Bioinformatics online.
Neuronal megalin mediates synaptic plasticity—a novel mechanism underlying intellectual disabilities in megalin gene pathologies
Authors: Gomes João R , Lobo Andrea , Nogueira Renata , Terceiro Ana F , Costelha Susete , Lopes Igor M , Magalhães Ana , Summavielle Teresa , Saraiva Maria J 
Published: August 2020

AbstractDonnai-Barrow syndrome, a genetic disorder associated to LRP2 (low-density lipoprotein receptor 2/megalin) mutations, is characterized by unexplained neurological symptoms and intellectual deficits. Megalin is a multifunctional endocytic clearance cell-surface receptor, mostly described in epithelial cells. This receptor is also expressed in the CNS, mainly in neurons, being involved in neurite outgrowth and neuroprotective mechanisms. Yet, the mechanisms involved in the regulation of megalin in the CNS are poorly understood. Using transthyretin knockout mice, a megalin ligand, we found that transthyretin positively regulates neuronal megalin levels in different CNS areas, particularly in the hippocampus. Transthyretin is even able to rescue megalin downregulation in transthyretin knockout hippocampal neuronal cultures, in a positive feedback mechanism via megalin. Importantly, transthyretin activates a regulated intracellular proteolysis mechanism of neuronal megalin, producing an intracellular domain, which is translocated to the nucleus, unveiling megalin C-terminal as a potential transcription factor, able to regulate gene expression. We unveil that neuronal megalin reduction affects physiological neuronal activity, leading to decreased neurite number, length and branching, and increasing neuronal susceptibility to a toxic insult. Finally, we unravel a new unexpected role of megalin in synaptic plasticity, by promoting the formation and maturation of dendritic spines, and contributing for the establishment of active synapses, both in in vitro and in vivo hippocampal neurons. Moreover, these structural and synaptic roles of megalin impact on learning and memory mechanisms, since megalin heterozygous mice show hippocampal-related memory and learning deficits in several behaviour tests. Altogether, we unveil a complete novel role of megalin in the physiological neuronal activity, mainly in synaptic plasticity with impact in learning and memory. Importantly, we contribute to disclose the molecular mechanisms underlying the cognitive and intellectual disabilities related to megalin gene pathologies.
3D Ultrastructural Study of Synapses in the Human Entorhinal Cortex
Authors: Domínguez-Álvaro M , Montero-Crespo M , Blazquez-Llorca L , DeFelipe J , Alonso-Nanclares L 
Published: August 2020

AbstractThe entorhinal cortex (EC) is a brain region that has been shown to be essential for memory functions and spatial navigation. However, detailed three-dimensional (3D) synaptic morphology analysis and identification of postsynaptic targets at the ultrastructural level have not been performed before in the human EC. In the present study, we used Focused Ion Beam/Scanning Electron Microscopy to perform a 3D analysis of the synapses in the neuropil of medial EC in layers II and III from human brain autopsies. Specifically, we studied synaptic structural parameters of 3561 synapses, which were fully reconstructed in 3D. We analyzed the synaptic density, 3D spatial distribution, and type (excitatory and inhibitory), as well as the shape and size of each synaptic junction. Moreover, the postsynaptic targets of synapses could be clearly determined. The present work constitutes a detailed description of the synaptic organization of the human EC, which is a necessary step to better understand the functional organization of this region in both health and disease.
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction
Authors: Withaar Coenraad , Meems Laura M G , Markousis-Mavrogenis George , Boogerd Cornelis J , Silljé Herman H W , Schouten Elisabeth M , Dokter Martin M , Voors Adriaan A , Westenbrink B Daan , Lam Carolyn S P , de Boer Rudolf A 
Published: August 2020

AbstractAimsHeart failure with preserved ejection fraction (HFpEF) is a multifactorial disease that constitutes several distinct phenotypes, including a common cardiometabolic phenotype with obesity and type 2 diabetes mellitus. Treatment options for HFpEF are limited, and development of novel therapeutics is hindered by the paucity of suitable preclinical HFpEF models that recapitulate the complexity of human HFpEF. Metabolic drugs, like glucagon-like peptide receptor agonist (GLP-1 RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2i), have emerged as promising drugs to restore metabolic perturbations and may have value in the treatment of the cardiometabolic HFpEF phenotype. We aimed to develop a multifactorial HFpEF mouse model that closely resembles the cardiometabolic HFpEF phenotype, and evaluated the GLP-1 RA liraglutide (Lira) and the SGLT2i dapagliflozin (Dapa).Methods and resultsAged (18–22 months old) female C57BL/6J mice were fed a standardized chow (CTRL) or high-fat diet (HFD) for 12 weeks. After 8 weeks HFD, angiotensin II (ANGII), was administered for 4 weeks via osmotic mini pumps. HFD + ANGII resulted in a cardiometabolic HFpEF phenotype, including obesity, impaired glucose handling, and metabolic dysregulation with inflammation. The multiple hit resulted in typical clinical HFpEF features, including cardiac hypertrophy and fibrosis with preserved fractional shortening but with impaired myocardial deformation, atrial enlargement, lung congestion, and elevated blood pressures. Treatment with Lira attenuated the cardiometabolic dysregulation and improved cardiac function, with reduced cardiac hypertrophy, less myocardial fibrosis, and attenuation of atrial weight, natriuretic peptide levels, and lung congestion. Dapa treatment improved glucose handling, but had mild effects on the HFpEF phenotype.ConclusionsWe developed a mouse model that recapitulates the human HFpEF disease, providing a novel opportunity to study disease pathogenesis and the development of enhanced therapeutic approaches. We furthermore show that attenuation of cardiometabolic dysregulation may represent a novel therapeutic target for the treatment of HFpEF.
Case report: high-grade atrioventricular block in suspected COVID-19 myocarditis
Authors: Ashok Vishnu , Loke Wei Ian 
Published: August 2020

Abstract

Background
In the ongoing pandemic of COVID-19, respiratory failure has been reported as the main cause of death in those who develop critical illness. A few cases of concurrent myocarditis have been reported, but the extent of cardiac complications with the SARS-CoV-2 strain of coronavirus is still largely unknown.

Case summary
A 53-year-old man, suspected to have COVID-19 due to a new-onset cough, shortness of breath, and hypoxia, was referred to Cardiology with sudden symptomatic bradycardia. Initial rhythm analysis revealed Type 2 atrioventricular block (Mobitz II). On arrival at the coronary care unit, he was found to be in complete heart block (Type 3). Routine blood tests showed normal electrolytes and renal function, and no elevation in troponin-I levels. Echocardiography showed mild impairment in left ventricular systolic function, with no regional wall motion abnormalities or valvular lesions. He then developed high-degree AV block lasting 6.2 s, prompting the need for an urgent permanent pacemaker implantation.

Discussion
Just over a third of patients with myocarditis reportedly develop a rise in cardiac troponin. Clinically suspected myocarditis can occur in the absence of a troponin rise and rarely can cause high-grade bradyarrhythmias. Myocarditis and non-specific cardiac arrhythmias have been reported in a few cases of COVID-19, but this is the first reported case of a high-grade atrioventricular conduction block with SARS-CoV-2 infection.
Coronary artery ectasia presenting with ST-elevation myocardial infarction in a young indigenous man: a case report
Authors: Lee John , Ramkumar Satish , Khav Nancy , Dundon Benjamin K 
Published: August 2020

Abstract

Background
Coronary artery ectasia (CAE) is often an incidental finding on angiography, however, patients can present with acute coronary syndrome due to a large thrombus burden requiring treatment with percutaneous coronary intervention or with emergency surgery.

Case summary
A 26-year-old Indigenous Australian male was admitted with anterior ST-elevation myocardial infarction associated with an out of hospital ventricular fibrillation arrest. Coronary angiography demonstrated thrombotic occlusion of the proximal left anterior descending (LAD) artery with heavy thrombus burden and prominent vascular ectasia of all three coronary arteries. He was managed with surgical thrombectomy and coronary artery bypass graft of his LAD.

Discussion
This is the first case of triple CAE in an Indigenous Australian. The case highlights the lack of consensus approach in the management of CAE due to paucity of prospective studies.
Network Structure and Performance
Authors: Lindenlaub Ilse , Prummer Anja 
Published: August 2020

AbstractWe develop a theory that links individuals’ network structure to their productivity and earnings. While a higher degree leads to better access to information, more clustering leads to higher peer pressure. Both information and peer pressure affect effort in a model of team production, with each being beneficial in a different environment. We find that information is particularly valuable under high uncertainty, whereas peer pressure is more valuable in the opposite case. We apply our theory to gender disparities in performance. We document the novel fact that men establish more connections (a higher degree) whereas women possess denser networks (a higher clustering coefficient). We therefore expect men to outperform women in jobs that are characterised by high uncertainty in project outcomes and earnings. We provide suggestive evidence that supports our predictions.
Impact of inter-amoebic phagocytosis on the L. pneumophila growth
Authors: Dey Rafik , Mameri Mouh Rayane , Trajkovic-Bodennec Selena , Bodennec Jacques , Pernin Pierre 
Published: August 2020

ABSTRACT
Free-living amoebae are known to act as replication niches for the pathogenic bacterium Legionella pneumophila in freshwater environments. However, we previously reported that some strains of the Willaertia magna species are more resistant to L. pneumophila infection and differ in their ability to support its growth. From this observation, we hypothesize that L. pneumophila growth in environment could be partly dependent on the composition of amoebic populations and on the possible interactions between different amoebic species. We tested this hypothesis by studying the growth of L. pneumophila and of a permissive free-living amoeba, Vermamoeba vermiformis (formerly named Hartmannella vermiformis), in co-culture with or without other free-living amoebae (Acanthamoeba castellanii and W. magna). We demonstrate the occurrence of inter-amoebic phagocytosis with A. castellanii and W. magna being able to ingest V. vermiformis infected or not infected with L. pneumophila. We also found that L. pneumophila growth is strongly impacted by the permissiveness of each interactive amoeba demonstrating that L. pneumophila proliferation and spread are controlled, at least in part, by inter-amoebic interactions.