bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Soil Loss Using Remote Sensing And GIS-Based Universal Soil Loss Equation In Northern Catchment of Lake Tana Sub-Basin, Upper Blue Nile Basin, Northwest Ethiopia
Authors: Balabathina Veera Narayana , RP Raju , Mulualem Wuletaw , Tadele Gedefaw 
Published: October 2020

Abstract
Background: Soil erosion, one of the major environmental challenges, is influenced by topography, climate, soil characteristics, and human activities and has a significant impact on potential land productivity and food security in many highland regions of Ethiopia. The present study attempts to estimate soil erosion risk in the Northern catchment of Lake Tana basin, situated in northwest part of Ethiopia, with available data through the application of the Universal Soil Loss Equation model integrated with Geographic Information System and remote sensing technologies to identify priority areas for controlling soil erosion. In addition, it analyzes the effect of land use and land cover, topography, erodibility, and drainage density on soil erosion potential of the catchment, and the possible relationships among them. Results: The results show that the mean annual soil loss of catchment is estimated at 37.89 ± 59.2 t ha−1yr−1 with a total annual soil loss of 1,705,370 tons. The topography (LS-factor), followed by the support practice (P-factor) and the soil erodibility (K-factor) were the most sensitive factors affecting soil erosion in the catchment. To identify high priority areas for management, the study area was subdivided into five major sub-basins and further categorized into five erosion classes based on erosion severity. The mean soil erosion rates of the Derma, Megech, Gumara, Garno, and Gabi Kura River sub-basins are 46.8, 40.98, 30.95, 30.04, and 29.66 t ha−1yr−1, respectively. About 58.9% of the area was found in very low erosion risk which extends from 0-1 t ha−1yr−1 and accounted only 1.1% of total soil loss, while 12.4% of the area was found to be under high and extreme erosion risk with erosion rates of 10 t ha−1yr−1 or more that contributes about 82.1% of total soil loss warrant high priority for reducing the risk of soil erosion. Conclusions: This study permits the understanding of the soil erosion process and the various factors that lead to the spatial variability of the risk in the catchment, and thus enhances the effectiveness of proposed conservation strategies for sustainable land management.
Prognosis Effects of Interventional Therapy on Patients with Coronary Slow Flow: An Observational Cohort Study
Authors: Guo Qixin , He Ying , Guan Yihong , Tong Guoxin , Shen Yun , Meng Shasha , Huang Jinyu 
Published: October 2020

Abstract
Background: The phenomenon of slow coronary blood flow is common clinically and is related to the patient experiencing repeated chest distress. The mechanism of slow blood flow is still unclear, and the prognosis after combined interventional therapy is unknown. Therefore, we evaluated the role of interventional therapy in this part of the population through the results of a 2-year follow-up.Methods: A total of 4663 patients who underwent continuous coronary angiography (CAG) were identified. Those patients with primary slow coronary flow were included in the study (n=369). The population was then divided into the PCI group and the N-PCI group. CTFT is used to assess the severity of slow blood flow. The endpoint events were the occurrence of rehospitalization and out-of-hospital death within 2 years. The log-rank test, Kaplan-Meier method, and Cox regression were used to evaluate and analyze the final results.Results: A total of 36 patients were readmitted to hospital, and 14 died suddenly outside the hospital during the follow-up period. Among these patients, 6 and 2 patients comprised the PCI group, while 30 and 12 patients comprised the N-PCI group. Comparison of the two groups showed no significant superiority (15.1% vs 13%, P=0.73). In Cox regression analysis, high BMI (body mass index) was an independent predictor of adverse end events (P=0.024).Conclusions: Interventional therapy may not improve outcomes in patients with slow coronary blood flow. BMI plays an important role in the influence of prognosis. Further research is needed to investigate this conclusion.
Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment
Authors: Wang Yimin , Zhao Xiaohuan , Gao Min , Wan Xiaoling , Guo Yinong , Qu Yingying , Chen Yuhong , Li Tong , Liu Haiyun , Jiang Mei , Wang Feng , Sun Xiaodong 
Published: October 2020

Abstract
Background: Photoreceptor death and neurodegeneration is the leading cause of irreversible vision loss. The inflammatory response of microglia plays an important role in the process of neurodegeneration. In this study, we examined the involvement of myosin 1f as a key regulator of immune cell activation via the AKT and MAPK pathways in microglia. Methods: We chose retinal detachment as the model of photoreceptor degeneration. Immunofluorescence and Western Blot was performed to confirm the expression and location of myosin 1f in detached retina. The RD mouse model was induced in WT and myosin 1f-/- mice and confirmed by HE and TUNEL staining. The expression of inflammatory cytokine and downstream pathways was assessed via qPCR and WB.Results: Myosin 1f was upregulated after retinal detachment, and it was specifically expressed in microglia. Deficiency of myosin 1f protected against cell death by inhibiting microglia activation. The elimination of microglia can abolish the protective effect of myosin 1f deficiency. After stimulation by LPS, microglia with myosin 1f deficiency showed downregulation of the MAPK and AKT pathways.Conclusions: Myosin 1f plays a crucial role in microglia-induced neuro-inflammation after retinal injury and photoreceptor degeneration by regulating 2 classic pathways, MAPK and AKT, and thereby decreasing the expression of inflammatory cytokines. Myosin 1f can be inhibited to prevent a decline in visual acuity after photoreceptor degeneration.
TCP1 Regulates PI3K/AKT/mTOR Signalling Pathway to Promote Ovarian Cancer Cell Proliferation
Authors: Weng Huixi , Feng Xiushan , Lan Yu , Zheng Zhiqun 
Published: October 2020

Abstract
ObjectiveTCP1 is one of the eight subunits of the TCP1 ring complex (TRiC) or the multi-protein mammalian cytosolic chaperone complex. TRiC participates in protein folding and regulates the expression of multiple signalling proteins and cytoskeletal components in cells. Although the clinical importance of its subunits has been clarified in various carcinomas, the function of TCP1 in ovarian cancer (OC) remains unclear. We aimed to identify the association between the expression of TCP1 and epithelial ovarian cancer (EOC) development and patients’ prognosis, and explore the underlying mechanisms of TCP1 on the tumour progression of ovarian cancer cells.MethodsTCP1 protein expression was tested in the various ovarian tissues by immunohistochemistry (IHC), and the correlation between TCP1 expression and clinical physiologic or pathologic parameters of EOC patients was analyzed in this study. The relationship between TCP1 expression and ovarian cancer patients’ prognosis was collected and analyzed using the Kaplan-Meier (KM) Plotter online database. Then, the expression levels of TCP1 was tested in different OC cell lines by Western blot. Furthermore, a model using ovarian cancer cell line A2780 was constructed for studying the functions of TCP1 in human EOC cell growth, migration, and invasion. Finally, possible regulated signalling pathways were discussed.ResultsTCP1 protein expression in ovarian cancer or borderline tissue was significantly higher compared to that in benign ovarian tumours and normal ovarian tissue. The upregulated expression of TCP1 in ovarian cancer was positively associated with and the differentiation grade and FIGO stage, which predicted poor clinical outcomes. Compared with IOSE-80 cells, TCP1 protein was overexpressed in the A2780 cells. TCP1 knockdown using shRNA lentivirus inhibited cell viability in A2780 cells. Western blot showed that the phosphatidylinositol-3 kinase (PI3K) signalling pathway was activated in the tumour invasion of EOC driven by TCP1. ConclusionThe protein level of TCP1 is overexpressed in aggressive histologic types of epithelial ovarian cancer. Upregulated TCP1 is correlated with poor prognosis of patients and TCP1 may serve as a novel prognostic biomarker. The mechanism of cancer progression promoted by TCP1 upregulation may be linked to the PI3K signalling pathway activation and TCP1 may serve as a novel target for ovarian cancer treatment.
Femtosecond pumping of nuclear isomeric states by the Coulomb collision of ions with quivering electrons
Authors: Fu Changbo , Feng Jie , Wang Wenzhao , Chen Liming , Tan Junhao , Li Yaojun , Wang Jinguang , Li Yifei , Zhang Guoqiang , Ma Yugang , Zhang Jie 
Published: October 2020

Abstract
Efficient production of metastable quantum states of nuclei (isomers) is critical for exotic applica- tions, like nuclear clocks, nuclear batteries, clean nuclear energy, and nuclear gamma-ray lasers[1–6]. However, due to low reaction cross sections and quick decay, it is extremely difficult to acquire sig- nificant amount of isomers with short lifetimes via traditional accelerators or reactors. Here, we present femtosecond pumping of nuclear isomeric states by the Coulomb excitation of ions with the quivering electrons induced by laser fields for the first time. Nuclear isomers populated on the second excited state of 83Kr, are generated with a rate of 3.84 × 10^17 per second from a table-top hundreds-TW laser system. This high efficiency of isomer production can be explained by Coulomb collision[7] of ions with the quivering electrons during the laser-cluster interactions at nearly solid densities.
The effects of canola and olive oils on lipid profile and fatty liver compared to sunflower oil in women with polycystic ovary syndrome: a randomized controlled trial
Authors: Yahay Maryam , Heidari Zahra , Allameh Zahra , Amani Reza 
Published: October 2020

Abstract
BackgroundPolycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies and metabolic disorders in women during their reproductive years and is often associated with dyslipidaemia and other cardiovascular diseases (CVD) risk factors. This study aimed to evaluate the effects of dietary intervention with canola and olive oils in comparison with sunflower oil on lipid profile and fatty liver severity among women with PCOS.MethodThis study was a 10 weeks intervention including 72 women with PCOS. Patients were randomly assigned to three groups to receive 25 g/day canola, olive, or sunflower oils for 10 weeks. The primary outcome was any changes in the lipid profile and the secondary outcome was a change in fatty liver severity.ResultAt the end of the study, 72 patients with a mean age of 29.31 were analyzed. Canola oil consumption led to a significant reduction in serum levels of triglycerides and TC/HDL (p = 0.021), LDL/HDL (p = 0.047), and TG/HDL (p = 0.001) ratios, but there was no significant reduction in lipid profile following olive oil consumption. Moreover, both the canola (p < 0.001) and olive oils (p = 0.005) could significantly reduce the fatty liver grade.ConclusionOverall, compared to the olive and sunflower oils, significant improvements in lipid profile and liver function were observed following consumption of canola oil in women with PCOS.Trial registrationIR.MUI.RESEARCH.REC.1397.315. Registered 30 JUNE 2019 - Retrospectively registered, https://www.irct.ir/trial/38684
Hydrous SiO2 in subducted oceanic crust and water transport to the core-mantle boundary
Authors: Lin Yanhao , Hu Qingyang , Yang Jing , Meng Yue , Zhuang Yukai , Walter Michael , Mao Ho-Kwang 
Published: October 2020

Abstract
Subduction of oceanic lithosphere transports surface water into the mantle where it can have remarkable effects, but how much can be cycled down into the deep mantle, and potentially to the core, remains ambiguous. Recent studies show that dense SiO2 in the form of stishovite, a major phase in subducted oceanic crust at depths greater than ~300 km, has the potential to host and carry water into the lower mantle. We investigate the hydration of stishovite and its higher-pressure polymorphs, CaCl2-type SiO2 and seifertite, in experiments at pressures of 44–152 GPa and temperatures of ~1380–3300 K. We quantify the water storage capacity of these dense SiO2 phases at high pressure and find that water stabilizes CaCl2-type SiO2 to pressures beyond the base of the mantle. We parametrize the P-T dependence of water capacity and model H2O storage in SiO2 along a lower mantle geotherm. Dehydration of slab mantle in cooler slabs in the transition zone can release fluids that hydrate stishovite in oceanic crust. Hydrous SiO2 phases are stable along a geotherm and progressively dehydrate with depth, potentially causing partial melting or silica enrichment in the lower mantle. Oceanic crust can transport ~0.2 wt% water to the core-mantle boundary region where, upon heating, it can initiate partial melting and react with the core to produce iron hydrides, providing plausible explanations for ultra-low velocity regions at the base of the mantle.
Dynamic Perfusion Digital Radiography for Predicting Pulmonary Function After Lung Cancer Resection
Authors: Jun Hanaoka , Yoden Makoto , Hayashi Kazuki , Shiratori Takuya , Okamoto Keigo , Kaku Ryosuke , Kawaguchi Yo , Ohshio Yasuhiko , Sonoda Akinaga 
Published: October 2020

Abstract
Background: Accurate prediction of postoperative pulmonary function is important for ensuring the safety of patients undergoing radical resection for lung cancer. Dynamic perfusion digital radiography is an excellent and easy imaging method for detecting blood flow in the lung compared with the less convenient conventional lung perfusion scintigraphy. As such, the present study aimed to confirm whether dynamic perfusion digital radiography can be evaluated in comparison with pulmonary perfusion scintigraphy in predicting early postoperative pulmonary function.Methods: Dynamic perfusion digital radiography and spirometry were performed before and 1 and 3 months after radical resection for lung cancer. Correlation coefficients between blood flow ratios calculated using dynamic perfusion digital radiography and pulmonary perfusion scintigraphy were then confirmed in the same cases. In all patients who underwent dynamic perfusion digital radiography, the correlation predicted values calculated from the blood flow ratio and measured values were examined. Furthermore, ppo%FEV1 or ppo%DLco values, which indicated the risk for perioperative complications, were examined.Results: A total of 52 participants who satisfied the inclusion criteria were analyzed. Blood flow ratios measured using pulmonary perfusion scintigraphy and dynamic perfusion digital radiography showed excellent correlation and acceptable predictive accuracy. Correlation coefficients between predicted FEV1 values obtained from dynamic perfusion digital radiography or pulmonary perfusion scintigraphy and actual measured values were similar. All patients who underwent dynamic perfusion digital radiography showed excellent correlation between predicted values and those measured using spirometry. A significant difference in ppo%DLco was observed for respiratory complications but not cardiovascular complications.Conclusions: Our study demonstrated that dynamic perfusion digital radiography can be a suitable alternative to pulmonary perfusion scintigraphy given its ability for predicting postoperative values and the risk for postoperative respiratory complications. Furthermore, it seemed to be an excellent modality because of its advantages, such as simplicity, low cost, and ease in obtaining in-depth respiratory functional information.Trial registration: Registered at UMIN, on 25 October 2017, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_his_list.cgi?recptno=R000033957Registration number: UMIN000029716
Development of a novel transcription factors-related prognostic signature for serous ovarian cancer
Authors: Li He , Liu Zhao-Yi , Wu Nayiyuan , Chen Yong-Chang , Cheng Quan , Wang Jing 
Published: October 2020

Abstract
BackgroundOvarian cancer (OC) is one of the most lethal gynecological cancer globally. Serous ovarian cancer (SOC) is most common pathological type of ovarian cancer. Growing evidence suggests that transcription factors (TFs) play vital roles in serous ovarian cancer (SOC). In the present study, we aimed to develop a transcription factors-related prognostic signature to better predict the survival in patients with SOC.Materials and methodsThe TFs mRNA expression profiles of 564 SOC subjects in the TCGA database, and 70 SOC subjects in the GEO database were screened. Lasso cox regression and consensus clustering analysis were utilized to construct a novel TFs related signature and cluster model, respectively. Genomic alternative analysis was used to elaborate on the association between the TFs related prognostic signature and genomic aberrations. GSEA analysis was applied to identify the biological functional difference between high risk-score group and low-risk score group.ResultsA 17-TFs related prognostic signature was constructed using lasso cox regression and validated in the TCGA and GEO cohorts. Consensus clustering analysis was applied to establish a cluster model. The 17-TFs related prognostic signature, risk score, and cluster models were effective at accurately distinguishing the prognosis of SOC. The GSEA assay results suggested that there was a significant difference in the inflammatory and immune response pathways between the high-risk and low-risk score groups. Immune infiltration, immunotherapy, and chemotherapy responses were analyzed due to the significant difference in the regulation of lymphocyte migration and T cell-mediated cytotoxicity between the two groups; indicating that patients with low-risk score were more likely to respond anti-PD-1, etoposide, paclitaxel, and veliparib but not to gemcitabine, doxorubicin, docetaxel, and cisplatin. Also, the prognostic nomogram model revealed that the risk score was a good prognostic indicator for SOC patients.ConclusionsIn conclusion, we explored the prognostic values of TFs in SOC and developed a 17-TFs related prognostic signature to predict the survival of SOC patients.
Desulfurization of Vulcanized Rubber Particles Using Biological and Chemical Methods
Authors: Valdés Cristian , Hernández Camila , Morales-Vera Rodrigo , Andler Rodrigo 
Published: October 2020

Abstract
Currently, recycling or degradation treatments for tires are an enormous challenge. Despite efforts to dispose of or recycle it, rubber waste is increasing year by year worldwide. To create a rubber-recycling system, several researchers have proposed tire desulfurization. In this study, we compare two methods: one biological, using Acidobacillus ferroxidans in shake 250 mL flask experiments, and one chemical using, for the first time, microwaves and an aqueous solution. The results of these methods were analyzed through sulfate quantification, cross-linking differences, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy with energy disperse spectroscopy (SEM-EDS). We observed that the amount of sulfates generated by the chemical system was 56 mg / L, which was 10-times higher than the biological system, which generated 5.3 mg / L. Similarly, after cross-linking studies, a 36% higher decrease after the chemical treatment was observed. When using FTIR analysis, the disappearance of characteristic bands corresponding to functional groups containing sulfur bonds was observed by treating the sample with both desulfurization mechanisms. Morphological changes on the rubber surface structure was also demonstrated by SEM-EDS analysis with the appearance of holes, cracks and changes in the porosity of the material. This work analyzed two different non-aggressive desulfurization mechanisms that might be used as sustainable methods for rubber recycling processes.
A Rechargeable Na/Cl Battery
Authors: Dai Hongjie , Zhu Guanzhou , Tian Xin , Tai Hung-Chun , Li Yuan-Yao , Li Jiachen , Sun Hao , Liang Peng , Angell Michael , Huang Cheng-Liang , Ku Ching-Shun , Hung Wei-Hsuan , Kai Jiang Shi , Meng Yongtao , Hwang Bing Joe 
Published: October 2020

Abstract
Sodium is a promising anode material for batteries due to its low standard electrode potential, high abundance and low cost. In this work, we report a new rechargeable ~ 3.5 V sodium ion battery using Na anode, amorphous carbon-nanosphere cathode and a starting electrolyte comprised of AlCl3 in SOCl2 with fluoride-based additives. The battery, exhibiting ultrahigh ~ 2800 mAh/g first discharge capacity, could cycle with a high reversible capacity up to ~ 1000 mAh/g. Through battery cycling, the electrolyte evolved to contain NaCl, various sulfur and chlorine species that supported anode’s Na/Na+ redox and cathode’s chloride/chlorine redox. Fluoride-rich additives were important in forming a solid-electrolyte interface, affording reversibility of the Na anode for a new class of high capacity secondary Na battery.
Baseline Global Longitudinal Strain Predictive of Anthracycline-Induced Cardiotoxicity
Authors: Araujo-Gutierrez Raquel , Chitturi Kalyan R. , Xu Jiaqiong , Wang Yuanchen , Kinder Elizabeth , Senapati Alpana , Chebrolu L Bindu , Kassi Mahwash , Trachtenberg Barry H. 
Published: October 2020

Abstract
Background: Anthracycline-induced cardiotoxicity is a major source of morbidity and mortality in long-term cancer survivors. Impaired GLS predicts decreased left ventricular ejection fraction (LVEF) in patients receiving anthracyclines, but knowledge regarding the clinical utility of baseline GLS in patients at low-risk of anthracycline-induced cardiotoxicity is limited. Objectives: The purpose of this study was to investigate whether baseline echocardiographic assessment of global longitudinal strain (GLS) before treatment with anthracyclines is predictive of cardiotoxicity in a broad cohort of patients with normal baseline LVEF..Methods: Study participants comprised 188 patients at a single institution who underwent baseline 2-dimensional (2D) speckle-tracking echocardiography before treatment with anthracyclines and at least one follow-up echocardiogram 3 months after chemotherapy initiation. Patients with a baseline LVEF <55% were excluded from the analysis. The primary endpoint, cardiotoxicity, was defined as an absolute decline in LVEF >10% from baseline and an overall reduced LVEF <50%. Potential and known risk factors were evaluated using univariable and multivariable Cox proportional hazards regression analysis. Results: Twenty-three patients (12.23%) developed cardiotoxicity. Among patients with cardiotoxicity, the mean GLS was -17.51% ± 2.77%. The optimal cutoff point for cardiotoxicity was -18.05%. The sensitivity was 0.70 and specificity was 0.70. The area under ROC curve was 0.70. After adjustment for cardiovascular and cancer therapy related risk factors, GLS or impaired baseline GLS ≥-18% was predictive of cardiotoxicity (adjusted hazards ratio 1.17, 95% confidence interval 1.00, 1.36; p=0.044 for GLS, or hazards ratio 3.54; 95% confidence interval 1.34, 9.35; p = 0.011 for impaired GLS), along with history of tobacco use, pre-chemotherapy systolic blood pressure, and cumulative anthracycline dose. Conclusions: Baseline GLS or impaired baseline GLS was predictive of cardiotoxicity before anthracycline treatment in a cohort of cancer patients with a normal baseline LVEF. This data supports the implementation of strain-protocol echocardiography in cardio-oncology practice for identifying and monitoring patients who are at elevated risk of anthracycline-induced cardiomyopathy.