bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex disparity in acute myeloid leukemia – evidence from a study of FLT3-ITD mutated patients
Authors: Engen Caroline , Hellesøy Monica , Grob Tim , Löwenberg Bob , Valk Peter J.M. , Gjertsen Bjørn T. 
Published: September 2020

AbstractLittle attention has been directed at untangling sex-related molecular and phenotypic differences in AML. While increased incidence and poor risk is generally associated with a male phenotype, FLT3-ITD, NPM1 and DNMT3A mutations are overrepresented in female AML. Here, we have investigated the relationship between sex and FLT3-ITD mutation status by comparing clinical data, mutational profiles, gene expression and ex vivo drug sensitivity responses in four cohorts: the Beat AML cohort, the LAML-TCGA cohort and two independent HOVON/SAKK clinical trial-associated cohorts, comprising a total of 1755 AML patients. We found that sex-associated molecular differences were prevalent in FLT3-ITD mutated AML. Co-occurrence of FLT3-ITD, NPM1 and DNMT3A mutations was overrepresented in females, while males with FLT3-ITDs were characterised by additional mutations in genes involved in RNA splicing and epigenetic modification. Female and male FLT3-ITD mutated AML had diverging expression of multiple leukemia-associated genes, as well as discrepant ex vivo drug-responses, suggestive of discrete functional properties. Surprisingly, we found significant prognostication of FLT3-ITD only in female patients. Thus, we suggest optimisation of FLT3-ITD mutation status as a clinical tool in a sex-adjusted manner. We further hypothesize that prognostication, prediction and development of therapeutic strategies in AML can be improved by including sex-specific considerations.
Privacy-Preserving and Robust Watermarking on Sequential Genome Data using Belief Propagation and Local Differential Privacy
Authors: Öksüz Abdullah Çağlar , Ayday Erman , Güdükbay Uğur 
Published: September 2020

AbstractMotivationGenome data is a subject of study for both biology and computer science since the start of Human Genome Project in 1990. Since then, genome sequencing for medical and social purposes becomes more and more available and affordable. Genome data can be shared on public websites or with service providers. However, this sharing compromises the privacy of donors even under partial sharing conditions. We mainly focus on the liability aspect ensued by unauthorized sharing of these genome data. One of the techniques to address the liability issues in data sharing is watermarking mechanism.ResultsTo detect malicious correspondents and service providers (SPs) -whose aim is to share genome data without individuals’ consent and undetected-, we propose a novel watermarking method on sequential genome data using belief propagation algorithm. In our method, we have two criteria to satisfy. (i) Embedding robust watermarks so that the malicious adversaries can not temper the watermark by modification and are identified with high probability (ii) Achievingϵ-local differential privacy in all data sharings with SPs. For the preservation of system robustness against single SP and collusion attacks, we consider publicly available genomic information like Minor Allele Frequency, Linkage Disequilibrium, Phenotype Information and Familial Information. Our proposed scheme achieves 100% detection rate against the single SP attacks with only 3% watermark length. For the worst case scenario of collusion attacks (50% of SPs are malicious), 80% detection is achieved with 5% watermark length and 90% detection is achieved with 10% watermark length. For all cases,ϵ’s impact on precision remained negligible and high privacy is ensured.Availabilityhttps://github.com/acoksuz/PPRW_SGD_BPLDPContactabdullahcaglaroksuz@gmail.com
Cohort Profile Update: GendAge and Berlin Aging Study II (BASE-II)
Authors: Demuth Ilja , Banszerus Verena L. , Drewelies Johanna , Düzel Sandra , Seeland Ute , Spira Dominik , Tse Esther , Braun Julian , Bertram Lars , Thiel Andreas , Lindenberger Ulman , Regitz-Zagrosek Vera , Gerstorf Denis ,   Additional BASE-II/GendAge investigators
Published: September 2020

AbstractThe study “Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany”, the GendAge study, focusses on major risk factors for cardiovascular and metabolic diseases and on the development of major outcomes from intermediate phenotypes in the context of biological sex and gender differences. It is based on a re-investigation of participants of the Berlin Aging Study II (BASE-II). The Berlin Aging Study II (BASE-II) is aiming at identifying factors that distinguish healthy from unhealthy ageing and completed baseline assessments in 2,200 adult volunteers (1,600 participants aged 60–80 years and 600 participants aged 20–35 years) in 2014. The BASE-II follow-up assessments of 1,100 men and women aged 65–94 years in 2018–2020 were part of GendAge. In addition to re-assessing most baseline measures (geriatrics, internal medicine, immunology and psychology) we implemented a comprehensive gender questionnaire covering socio-cultural gender characteristics and added high-quality echocardiography.
Alfaxalone activates Human Pregnane-X Receptors with greater efficacy than Allopregnanolone: an in-vitro study with implications for neuroprotection during anesthesia
Authors: Serrao Juliet.M. , Goodchild Colin.S. 
Published: September 2020

AbstractBackgroundAlfaxalone is a fast acting intravenous anesthetic with high therapeutic index. It is an analogue of the naturally-occurring neurosteroid, allopregnanolone which has been implicated in causing neuroprotection, neurogenesis and preservation of cognition, through activation of pregnane X receptors in the central nervous system. This study investigated whether alfaxalone can activate human pregnane X receptors (h-PXR) as effectively as allopregnanolone.MethodsAllopregnanolone and alfaxalone were dissolved in dimethyl sulfoxide to make allopregnanolone and alfaxalone treatment solutions (serial 3-fold dilution concentration range, 50,000 – 206 nM). Activation of h-PXR by these ligand solutions compared with vehicle control was measured by an in-vitro method using human embryonic kidney cells (HEK293) expressing h-PXR hybridised and linked to the firefly luciferase gene. Ligand binding with and activation of h-PXR in those cells caused downstream changes in luciferase activity and light emission. That activity was measured as relative light units using a plate-reading luminometer, thus quantifying the changes in h-PXR activity caused by the ligand applied to the HEK293 cells. Ligand log concentration response curves were constructed to compare efficacy and potency of allopregnanolone and alfaxalone.ResultsAllopregnanolone and alfaxalone both activated the h-PXR to cause dose-related light emission by the linked firefly luciferase. Control solutions (0.1% dimethyl sulfoxide) produced low level light emissions. Equimolar concentrations of alfaxalone were more efficacious in activation of h-PXR: 50,000 nM, p = 0.0019; 16,700 nM, p = 0.0472; 5,600 nM, p = 0.0031 [Brown-Forsythe and Welch ANOVA].ConclusionsAlfaxalone activates human-pregnane X receptors with greater efficacy compared with the endogenous ligand allopregnanolone. These results suggest that alfaxalone sedation and anesthesia may be accompanied by beneficial effects normally caused by the physiological effects of allopregnanolone, namely neuroprotection, neurogenesis, and preservation of cognition.
Genomic analysis reveals local transmission of SARS-CoV-2 in early pandemic phase in Peru
Authors: Padilla-Rojas Carlos , Vega-Chozo Karolyn , Galarza-Perez Marco , Calderon Henri Bailon , Lope-Pari Priscila , Balbuena-Torres Johanna , Neyra David Garcia , Huaringa-Nuñez Maribel , Rojas-Serrano Nancy , Caceres-Rey Omar A. 
Published: September 2020

ABSTRACTThe dissemination of cases of the new SAR-COV-2 coronavirus represents a serious public health problem for Latin America and Peru. For this reason, it is important to characterize the genome of the isolates that circulate in Latin America. To characterize the complete genome of first samples of the virus circulating in Peru, we amplified seven overlapping segments of the viral genome by RT-PCR and sequenced using Miseq platform. The results indicate that the genomes of the Peruvian SARS-COV-2 samples belong to the genetic groups G and S. Likewise, a phylogenetic and MST analysis of the isolates confirm the introduction of multiple isolates from Europe and Asia that, after border closing, were transmitted locally in the capital and same regions of the country. These Peruvian samples (56%) grouped into two clusters inside G clade and share B.1.1.1 lineage. The characterization of these isolates must be considered for the use and design of diagnostic tools, and effective treatment and vaccine formulations.
New insights into nCOVID-19 binding domain and its cellular receptors
Authors: Garg Ankush , Kumar Gaurav , Sinha Sharmistha 
Published: September 2020

AbstractnCOVID-19 virus makes cellular entry using its spike protein protruding out on its surface. Angiotensin converting enzyme 2 receptor has been identified as a receptor that mediates the viral entry by binding with the receptor binding motif of spike protein. In the present study, we elucidate the significance of N-terminal domain of spike protein in spike-receptor interactions. Recent clinical reports indicate a link between nCOVID-19 infections with patient comorbidities. The underlying reason behind this relationship is not clear. Using molecular docking, we study the affinity of the nCOVID-19 spike protein with cell receptors overexpressed under disease conditions. Our results suggest that certain cell receptors such as DC/L-SIGN, DPP4, IL22R and ephrin receptors could act as potential receptors for the spike protein. The receptor binding domain of nCOVID-19 is more flexible than that of SARS-COV and has a high propensity to undergo phase separation. Higher flexibility of nCOVID-19 receptor binding domain might enable it to bind multiple receptor partners. Further experimental work on the association of these receptors with spike protein may help us to explain the severity of nCOVID-19 infection in patients with comorbidities.
Understanding mobile payment continuance usage in physical store through social impact theory and trust transfer
Authors: Handarkho Yonathan Dri 
Published: September 2020

PurposeThis study aimed to understand mobile payment (MP) continuance usage in physical settings from trust and social experience perspective. A theoretical model was proposed based on trust transfer and social impact to reveal the factors influencing user intention to continually use MP.Design/methodology/approachStructural equation modeling (SEM) analysis was used on 308 respondents from Indonesia to examine the theoretical model while principal component factor analysis and descriptive statistics were utilized for data preparation.FindingsThe findings revealed the Perceived Herd behavior had the most significant contribution to Trust formation followed by Perceived Risk and Para-social interaction while the analysis of indirect and moderating effect was also significant in enriching the result.Originality/valueThis study postulated social experience as an antecedent factor to the formation of Trust in the MP continuance usage context. Moreover, while the commonly explored direct effect was investigated, the indirect effect and moderating impact that has not been addressed adequately in previous MP studies were also analyzed and this can be considered as a contribution to the body of knowledge.
“Income vs. education” revisited – the roles of “family face” and gender in Chinese consumers' luxury consumption
Authors: Mo Tingting 
Published: September 2020

PurposeThe transgenerational influence of inherited family capital on consumers' luxury consumption has been studied recently in the mature luxury market. However, little research explores this topic in the emerging luxury market. In China's Confucian culture, “family face” as part of “family inheritance” has been conceptualized as a factor driving luxury consumption. However, this hypothesis has not been empirically tested. The current research, therefore, seeks to examine the impact of economic and cultural capital on Chinese consumers' luxury consumption within the family inheritance context and the roles that face concern and gender play to reveal the particularities of a specific emerging luxury market.Design/methodology/approachA sample of 324 Chinese consumers was recruited in Shanghai. With the full sample, the author first assessed the effects of economic and educational capital (both personal and family sources) and face concern on luxury consumption using regression analyses. Next, the author conducted the regression analyses again by gender.FindingsUnlike trends in the mature luxury market, Chinese consumers' educational levels do not drive their luxury consumption, and the transgenerational influence of economic and cultural capital functions as a negative factor. Influenced by the patrilineal tradition, higher levels of luxury consumption to compensate for parents' lower income and educational levels and to enhance family face are found only in the male consumer group, but not in the female group.Originality/valueThis research contributes to expanding the current understanding of emerging luxury markets and how the Confucian tradition influences Chinese consumers' luxury consumption through gender role norms.
Service quality dimensions of ride-sourcing services in Indian context
Authors: Shah Tejas R. 
Published: September 2020

PurposeThis paper aims to identify the dimensions of service quality in the case of ride-sourcing services in Indian context.Design/methodology/approachThe service quality dimensions of ride-sourcing services are identified using an exploratory factor analysis (EFA). Further, the reliability and validity of the factors are established through confirmatory factor analysis (CFA) using AMOS.FindingsThe service quality dimensions of ride-sourcing services are identified: comfort, internal environment, safety and personnel, mobile convenience and reliability, mobile system efficiency and availability, mobile customer service and billing and mobile security and privacy.Research limitations/implicationsThe various dimensions are identified to measure service quality of ride-sourcing services in India. So, these dimensions can be tested for ride-sourcing services of countries having similar culture as India.Practical implicationsThe proposed dimensions can be used as a diagnostic tool to identify and compare important criteria for service quality of ride-sourcing services.Originality/valueMost relevant studies about dimensions of service quality for ride-sourcing services do not have stable factor structure. The dimensions identified include the traditional taxi service quality and mobile app service quality, which are not covered in current literature.
An emotion-based segmentation of bank service customers
Authors: Calvo-Porral Cristina , Lévy-Mangin Jean-Pierre 
Published: September 2020

PurposeEmotional and affective responses are experienced during service use that determine customer behavior; and for this reason, bank services require an better understanding of the emotions customers feel in service experiences. This research aims to examine whether different customer segments exist in the bank services industry, based on the emotions they experience when using the service.Design/methodology/approachThe factors were examined through confirmatory factor analysis (CFA). Then, two-step clustering analysis was developed for customer segmentation on data from 451 bank service customers. Finally, an Anova test was conducted to confirm the differences among the obtained customer segments.FindingsOur findings show that the emotion-based segmentation is meaningful in terms of behavioral outcomes in bank services. Further, research findings indicate that bank service customers cannot be perceived as a homogenous group, since four customer clusters emerge from our research namely “angry complainers”, “pragmatic uninvolved”, “emotionally attached customers” and “happy satisfied customers”.Research limitations/implicationsOur findings show that the emotion-based segmentation is meaningful in terms of behavioral outcomes in bank services. Further, research findings indicate that bank service customers cannot be perceived as a homogenous group, since four customer clusters emerge from our research namely “angry complainers”, “pragmatic uninvolved”, “emotionally attached customers” and “happy satisfied customers”, being the “angry complainers” the most challenging customer group.Originality/valueThe study is the first one to specifically segment bank customers based on the emotions they experience when using the service.
The role of job involvement and career commitment between person–job fit and organizational commitment: a study of higher education sector
Authors: Jyoti Jeevan , Sharma Poonam , Kour Sumeet , Kour Harleen 
Published: September 2020

PurposeOrganizations try to appoint individuals who fit in with their values and goals. Employees who do not fit in with the organization's core values and goals prefer not to stay on for a longer period of time. The present study is an attempt to explore the impact of person–job (P–J) fit on organizational commitment through job involvement and career commitment with an application of a serial multiple mediation model.Design/methodology/approachData have been collected through a structured questionnaire. The population comprised the teachers, working in the higher education sector. The different constructs used have been duly validated with the help of exploratory and confirmatory factor analyses. Further data reliability and scale validity have been checked too. In order to test the serial multiple mediation model, the authors adopted a regression-based approach and bootstrapping method suggested by Hayes (2012; 2013). Accordingly, PROCESS developed by Hayes (2012) has been used.FindingsThe results revealed that job involvement and career commitment mediate the relationship between P–J fit and organizational commitment individually as well as together.Research limitations/implicationsThe present study is confined to government degree colleges only. The element of subjectivity might not have been checked completely as teachers have responded on the basis of their own experience and perceptions regarding the items in the questionnaire. The study is cross sectional in nature.Practical implicationsThe paper addresses the interest of wide spectrum of stakeholders including the management, organizations and employees. So, the authors have extended general implications, which are for all those organizations that want to improve person–organization (P–O) fit and commitment of their employees. These implications will help organizations to take specific initiatives to improve the P–J fit of their employees, which will subsequently enhance their commitment level.Originality/valueThe findings of the present study will help the stakeholders in the higher education sector to identify best employees and undertake the initiatives to generate better job involvement and commitment, which will be a win–win strategy for both (employees as well as the organizations).
Robust facility location decisions for resilient sustainable supply chain performance in the face of disruptions
Authors: Sundarakani Balan , Pereira Vijay , Ishizaka Alessio 
Published: September 2020

PurposeFacility location and re-location decisions are critical managerial decisions in modern supply chains. Such decisions are difficult in this environment as managers encounter uncertainty and risks. The study investigates establishing or moving distribution facilities in the global supply chain by considering costs, fulfilment, trade uncertainties, risks under environmental trade-offs and disruptive technologies.Design/methodology/approachThis paper combines the possibilities and probabilistic scenarios for a supply chain network by proposing the novel Robust Optimisation and Mixed Integer Linear Programming (ROMILP) method developed under the potential uncertainty of demand while considering the costs associated with a four-tier supply chain network. ROMILP has been solved in a real-time logistics environment by applying a case study approach.FindingsThe solution is obtained using an exact solution approach and provides optimality in all tested market scenarios along the proposed global logistics corridor. A sensitivity analysis examines potential facility location scenarios in a global supply chain context.Research limitations/implicationsLogistics managers can apply the ROMILP model to test the cost-benefit trade-offs against their facility location and relocation decisions while operating under uncertainty. Future research is proposed to extend the literature by applying data from the OBOR logistics corridor.Originality/valueThis study is the first to examine sustainable dimensions along the global logistics corridor and investigate the global container traffic perspective. The study also adds value to the Middle East logistics corridor regarding facility location decisions.
The safety of IoT-enabled system in smart cities of India: do ethics matter?
Authors: Chatterjee Sheshadri 
Published: September 2020

Purpose
The purpose of this study is to analyze the impact of ethics and technology towards safety of internet of things (IoT)-enabled system in smart cities of India (SCI).

Design/methodology/approach
The determinants that would impact on securing IoT-enabled system in SCI have been identified by the studies of literature. Some hypothesis has been formulated. A conceptual model has been developed. Hypotheses and conceptual models have been tested by a statistical approach through survey works considering the feedbacks of 331 usable respondents. The results have been discussed followed by explaining the implications of this study. A comprehensive conclusion has been provided at the end.

Findings
The validated results show that the trust factor has insignificant impacts on the system and technology use, as well as on the behavioural intention. The model provided could achieve 79% explanative power.

Practical implications
For ensuring safety and security of IoT-enabled devices in SCI, the ethical sense of the stakeholders of SCI has considerable impact on securing safety of IoT-enabled devices in SCI. The practitioner should, as such, be sincere to motivate the stakeholders to ameliorate the ethical sense of the stakeholders for securing safety of IoT-enabled devices in SCI.

Originality/value
A few studies in the areas of Indian smart cities, IoT and related ethical issues have been conducted. In that sense, this approach is deemed to be a novel attempt.