bluuebunny/crossref_metadata_2025_split huggingface dataset:
The experience of the health care workers of a severely hit SARS-CoV-2 referral Hospital in Italy: incidence, clinical course and modifiable risk factors for COVID-19 infection
Authors: Colaneri Marta , Novelli Viola , Cutti Sara , Muzzi Alba , Resani Guido , Monti Maria Cristina , Rona Claudia , Grugnetti Anna Maria , Rettani Marco , Rovida Francesca , Zuccaro Valentina , Triarico Antonio , Marena Carlo 
Published: October 2020

Abstract

Background
During the COVID-19 pandemic, the health care workers (HCWs) at the frontline have been largely exposed to infected patients, running a high risk of being infected by the SARS-CoV-2 virus.
Since limiting transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in health care setting is crucial to avoid the community spread of SARS-CoV-2, we want to share our experience as an early hit hospital where standard infection control practices have been conscientiously applied and effective. We believe that our example, as first and hardest hit country, might be a warning and aid not only for those who have been hit later, but also for a second fearful wave of contagion. In addition, we want to offer an insight on modifiable risk factors for HWs-related infection.

Methods
Demographic, lifestyle, work-related and comorbidities data of 1447 HCWs, which underwent a nasopharyngeal swab for SARS-CoV-2, were retrospectively collected. For the 164 HCWs positive for SARS-CoV-2, data about safety in the workplace, symptoms and clinical course of COVID-19 were also collected. Cumulative incidence of SARS-CoV-2 infection was estimated. Risk factors for SARS-CoV-2 infection were assessed using a multivariable Poisson regression.

Results
The cumulative incidence of SARS-CoV-2 infection among the screened HCWs was 11.33% (9.72–13.21). Working in a COVID-19 ward, being a former smoker (versus being a person who never smoked) and BMI was positively associated with SARS-CoV-2 infection, whereas being a current smoker was negatively associated with this variable.

Conclusions
Assuming an equal accessibility and proper use of personal protective equipment of all the HCWs of our Hospital, the great and more prolonged contact with COVID-19 patients remains the crucial risk factor for SARS-CoV-2. Therefore, increased and particular care needs to be focused specifically on the most exposed HCWs groups, which should be safeguarded. Furthermore, in order to limit the risk of asymptomatic spread of SARS-CoV-2 infection, the HCWs mild symptoms of COVID-19 should be considered when evaluating the potential benefits of universal staff testing.
Myopia, or near-sightedness, is associated with delayed melatonin circadian timing and lower melatonin output in young adult humans
Authors: Chakraborty Ranjay , Micic Gorica , Thorley Lisa , Nissen Taylah R , Lovato Nicole , Collins Michael J , Lack Leon C 
Published: October 2020

AbstractStudy objectivesMyopia, or near-sightedness, is the most common refractive vision disorder and predisposes the eye to many blinding conditions in adulthood. Recent research has suggested that myopia is associated with increased endogenous melatonin production. Here we investigated the differences in melatonin circadian timing and output in young adult myopes and non-myopes (or emmetropes) as a pathogenesis for myopia.MethodsA total of 18 myopic (refractive error [mean ± standard deviation] −4.89 ± 2.16 dioptres) and 14 emmetropic participants (−0.09 ± 0.13 dioptres), aged 22.06 ± 2.35 years were recruited. Circadian timing was assessed using salivary dim light melatonin onset (DLMO), collected half-hourly for 7 h, beginning 5 h before and finishing 2 h after individual average sleep onset in a sleep laboratory. Total melatonin production was assessed via aMT6s levels from urine voids collected from 06:00 pm and until wake-up time the following morning. Objective measures of sleep timing were acquired a week prior to the sleep laboratory visit using an actigraphy device.ResultsMyopes (22:19 ± 1.8 h) exhibited a DLMO phase-delay of 1 hr 12 min compared with emmetropes (21:07 ± 1.4 h), p = 0.026, d = 0.73. Urinary aMT6s melatonin levels were significantly lower among myopes (29.17 ± 18.67) than emmetropes (42.51 ± 23.97, p = 0.04, d = 0.63). Myopes also had a significant delay in sleep onset, greater sleep onset latency, shorter sleep duration, and more evening-type diurnal preference than emmetropes (all p &lt; 0.05).ConclusionsThese findings suggest a potential association between circadian rhythms and myopia in humans.
SBM Mid-Career Leadership Institute
Authors: Affuso Olivia 
Published: October 2020

Abstract
My purpose for participating in the 2017 Society for Behavior Medicine (SBM) Leadership Institute was to redefine my career goals in an effort to do more work that mattered. I felt overwhelmed by the numerous tasks as a mid-level researcher, including leadership roles outside of my university to fill a desire to pursue activities that were purposeful but not valued by the academy. For example, I served on the Board of Girls on the Run (GOTR) where I was chair, leading a team of about 12 board members to provide a running-based life skills program for girls in Grades 3–5. After stepping down from the Board, I chose to develop a partnership between GOTR and the University of Alabama at Birmingham’s Center for Exercise Medicine (UCEM) that would provide an opportunity for me to lead an outreach effort extending the GOTR program into Birmingham City Schools. The goal was not only to reach more girls from disadvantaged backgrounds but also to also reach their family members. We used survey results to assess parent/family preferences for receiving physical activity training resources to be able to support their girls at the end-of-the program 5K celebration. The resources were made available via the UCEM website and a link was sent by GOTR to all families of participants in the program. Overall, the partnership allowed us to reach more girls and their families and I know that the SBM Leadership program contributed to my delegation and organizational skills coupled with coaching to reveal my strengths and blind spots.
Justification for species selection for pharmaceutical toxicity studies
Authors: Prior Helen , Haworth Richard , Labram Briony , Roberts Ruth , Wolfreys Alison , Sewell Fiona 
Published: October 2020

AbstractToxicity studies using mammalian species are generally required to provide safety data to support clinical development and licencing registration for potential new pharmaceuticals. International regulatory guidelines outline recommendations for the order (rodent and/or non-rodent) and number of species, retaining flexibility for development of a diverse range of drug modalities in a manner relevant for each specific new medicine. Selection of the appropriate toxicology species involves consideration of scientific, ethical and practical factors, with individual companies likely having different perspectives and preferences regarding weighting of various aspects dependent upon molecule characteristics and previous experience of specific targets or molecule classes. This article summarizes presentations from a symposium at the 2019 Annual Congress of the British Toxicology Society on the topic of species selection for pharmaceutical toxicity studies. This symposium included an overview of results from a National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and Association of British Pharmaceutical Industry (ABPI) international collaboration that reviewed the use of one or two species in regulatory toxicology studies and justification for the species selected within each programme. Perspectives from two pharmaceutical companies described their processes for species selection for evaluation of biologics, and justification for selection of the minipig as a toxicological species for small molecules. This article summarizes discussions on the scientific justification and other considerations taken into account to ensure the most appropriate animal species are used for toxicity studies to meet regulatory requirements and to provide the most value for informing project decisions.
Assumptions About Competency-Based Medical Education and the State of the Underlying Evidence: A Critical Narrative Review
Authors: Brydges Ryan , Boyd Victoria A. , Tavares Walter , Ginsburg Shiphra , Kuper Ayelet , Anderson Melanie , Stroud Lynfa 
Published: October 2020

Purpose
As educators have implemented competency-based medical education (CBME) as a framework for training and assessment, they have made decisions based on available evidence and on the medical education community’s assumptions about CBME. This critical narrative review aimed to collect, synthesize, and judge the existing evidence underpinning assumptions the community has made about CBME.

Method
The authors searched Ovid MEDLINE to identify empirical studies published January 2000 to February 2019 reporting on competence, competency, and CBME. The knowledge synthesis focused on “core” assumptions about CBME, selected via a survey of stakeholders who judged 31 previously identified assumptions. The authors judged, independently and in pairs, whether evidence from included studies supported, did not support, or was mixed related to each of the core assumptions. Assumptions were also analyzed to categorize their shared or contrasting purposes and foci.

Results
From 8,086 unique articles, the authors reviewed 709 full-text articles and included 189 studies reporting evidence related to 15 core assumptions. Most studies (80%; n = 152) used a quantitative design. Many focused on procedural skills (48%; n = 90) and assessed behavior in clinical settings (37%; n = 69). On aggregate, the studies produced a mixed evidence base, reporting 362 data points related to the core assumptions (169 supportive, 138 not supportive, and 55 mixed). The 31 assumptions were organized into 3 categories: aspirations, conceptualizations, and assessment practices.

Conclusions
The reviewed evidence base is significant but mixed, with limited diversity in research designs and the types of competencies studied. This review pinpoints tensions to resolve (where evidence is mixed) and research questions to ask (where evidence is absent). The findings will help the community make explicit its assumptions about CBME, consider the value of those assumptions, and generate timely research questions to produce evidence about how and why CBME functions (or not).
Learning Echocardiography in the Workplace: A Cognitive Load Perspective
Authors: Blissett Sarah , Rodriguez Sebastian , Qasim Atif , O’Sullivan Patricia 
Published: October 2020

Purpose
Although workplace learning environments provide authentic tasks to promote learning, elements of clinical settings may distract trainees and impede learning. The characteristics of workplace learning environments that require optimization are ill-defined. Applying principles of cognitive load theory (CLT) to optimize learning environments by managing intrinsic load (complexity of the task matched to learner knowledge and skill), minimizing extraneous load (any aspect that is not part of task completion), and increasing germane load (processing for storage in long-term memory) could be advantageous. The authors explored trainee perceptions of characteristics that helped or impaired learning from a cognitive load perspective. Echocardiography interpretation was used as a model.

Method
The authors conducted semistructured interviews between December 2018 and March 2019 with a purposeful sample of 10 cardiology trainees at the University of California, San Francisco, School of Medicine until thematic sufficiency was achieved. Participants represented a range of training levels (3 fourth-year trainees, 2 fifth-year trainees, 3 sixth-year trainees, and 2 advanced echocardiography fellows) and career aspirations (4 desired careers in imaging). Two independent coders analyzed interview transcripts using template analysis. Codes were mapped to CLT subcomponents.

Results
Trainees selected their own echocardiograms to interpret; if trainees’ skill levels and the complexity of the selected echocardiograms were mismatched, excess intrinsic load could result. Needing to look up information essential for task completion, interruptions, reporting software, and time pressures were characteristics that contributed to extraneous load. Characteristics that related to increasing germane load included the shared physical space (facilitating reading echocardiograms with attendings and just-in-time guidance from near peers) and the availability of final reports to obtain feedback independent of teachers.

Conclusions
As interpreted from a cognitive load perspective, findings highlight characteristics of workplace learning environments that could be optimized to improve learning. The findings have direct application to redesigning these learning environments.
The Relationship Between Burnout and Help-Seeking Behaviors, Concerns, and Attitudes of Residents
Authors: Dyrbye Liselotte N. , Leep Hunderfund Andrea N. , Winters Richard C. , Moeschler Susan M. , Vaa Stelling Brianna E. , Dozois Eric J. , Satele Daniel V. , West Colin P. 
Published: October 2020

Purpose
To evaluate the relationship between help-seeking concerns and attitudes and burnout among residents.

Method
In 2019, all residents across the 4 Mayo Clinic sites were surveyed. The survey included 2 items from the Maslach Burnout Inventory, an item from the National Comorbidity Survey Replication about likelihood of seeking professional help for a serious emotional problem, and items developed to explore residents’ help-seeking behaviors and concerns. Multivariable logistic regression was conducted for each outcome variable and included age, gender, specialty, postgraduate year, site, and burnout.

Results
Of the 1,146 residents to whom surveys were sent, 762 (66.5%) responded. Nearly half (342/747, 45.8%) were concerned about negative consequence to their career if they went on medical leave, and one-third (247/753, 32.8%) were reluctant to seek professional help for a serious emotional concern. Of the 437 residents who had never attended a personal health appointment during scheduled work, 34.6% (151) thought it would be difficult to tell a supervising physician they needed to miss work due to a scheduled appointment. On multivariable analysis, burnout was independently associated with reporting it would be difficult to tell a supervising physician of a need to attend an appointment (odds ratio [OR] 2.32; 95% confidence interval [CI] 1.46, 3.67; P < .001), being concerned about negative consequence to their career if they went on medical leave (OR 2.09; 95% CI 1.49, 2.93; P < .001), and reluctance to seek professional care for a serious emotional problem (OR 1.65; 95% CI 1.17, 2.34; P = .004).

Conclusions
Barriers to self-care and help-seeking are common among residents and may be worse among those with burnout. Strategies to reduce stigma and promote a culture of well-being are needed.
Cardiac Rehabilitation Knowledge and Attitudes of Cardiology Fellows
Authors: Kellar Garrett , Hickey Gavin W. , Goss Fredric , Fertman Carl , Forman Daniel E. 
Published: October 2020

Purpose:
Cardiac rehabilitation (CR) is underutilized with only 8-31% of eligible patients participating. Lack of referral and lack of physician endorsement are well-known barriers to participation. Physicians who lack insights regarding CR are less likely to refer patients and recommend it. Cardiology fellows are early career physicians who spend a significant amount of time treating patients eligible for CR. At one institution's cardiology fellowship program, we sought to assess fellow attitudes and knowledge base regarding CR and to determine their facilitators and barriers to CR endorsement and referral.

Methods:
University of Pittsburgh Department of Medicine Cardiology fellows were surveyed and interviewed to assess CR knowledge, attitudes, and perceived facilitators and barriers to CR endorsement and referral.

Results:
The cardiology fellows at this institution had strong belief in the benefits and cost-effectiveness of CR. Despite their support of CR, they had low CR knowledge scores. Perceived impediments to CR included complicated logistics of CR operations, limited communication between CR staff and fellows, limited time with patients, presumed patient barriers, perceived self-barriers, and poor understanding of referral processes (particularly as they varied in each hospital in which they rotated). Perceived supports to CR included greater awareness of evidence-based outcomes, awareness of patient-centered outcomes, pre-arranged order sets, and reminders for referral.

Conclusion:
This study revealed perceptions of cardiology fellows at one institution regarding CR that have not been considered previously. Key barriers to endorsement and referral to CR were exposed as well as opportunities to overcome them. Fellowship training affords an important opportunity to improve CR education, and to potentially improve participation of eligible patients for this important aspect of care.
Antihypertensive therapy and short-term blood pressure variability
Authors: de la Sierra Alejandro , Mateu Aina , Gorostidi Manuel , Vinyoles Ernest , Segura Julián , Ruilope Luis M. 
Published: October 2020

Background and aim:
Blood pressure variability (BPV) is recognized as a prognostic contributor in hypertension. We aimed to assess differences in short-term BPV in treated hypertensive patients depending on the number, classes, combinations and individual compounds of the antihypertensive treatment.

Methods:
We selected 38 188 treated patients from the Spanish Ambulatory BP Monitoring (ABPM) Registry. SBP and DBP standard deviations (SD) from 24-h, daytime and night-time, weighted SD (WSD), and average real variability (ARV) were calculated through ABPM. They were compared (after adjustment for clinical confounders and BP) depending on the number of antihypertensive drugs, antihypertensive drug classes and compounds (in 13 765 patients on monotherapy), or combinations (in 12 716 patients treated with two drugs and 7888 treated with three drugs).

Results:
Systolic and diastolic BPV significantly increased in patients treated with multiple drugs with respect to monotherapy. Among drug classes, calcium channel blockers, especially amlodipine, and diuretics were associated with lower systolic BPV, including daytime and night-time SD, WSD and ARV, compared with beta blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Likewise, in patients treated with two-drug and three-drug combinations, those which included a calcium channel blocker showed lower BPV in comparison to those without such drug class.

Conclusion:
Treatment with calcium channel blockers, especially amlodipine, and with diuretics is associated with slight, but significant lower values of short-term BPV in comparison to other major drug classes, both in monotherapy and in combination. These results could be helpful when considering BPV reduction as an additional treatment target.
A novel method to assess valvulo-arterial load in patients with aortic valve stenosis
Authors: Hungerford Sara L. , Adji Audrey I. , Bart Nicole K. , Lin Linda , Namasivayam Mayooran J. , Schnegg Bruno , Jabbour Andrew , O’Rourke Michael F. , Hayward Christopher S. , Muller David W.M. 
Published: October 2020

Introduction:
Ventricular function in elderly patients with aortic stenosis is impeded both by restricted aortic flow and arterial stiffening. A number of patients continue to have exertional intolerance after relief of aortic valvular obstruction due to unrecognized ventriculo-arterial coupling mismatch.

Hypothesis:
Quantification of valvulo-arterial load (VAL), using a simultaneous applanation tonometry/cardiac magnetic resonance (CMR) technique, can accurately assess the relative contributions of aortic stiffness and valve gradient in older patients with aortic stenosis.

Methods:
Elderly patients with aortic stenosis underwent a simultaneous applanation tonometry/CMR protocol. CMR provided left ventricular volume and aortic flow simultaneously with radial applanation tonometry pressure acquisition. Central aortic pressure was derived by transformation of the radial applanation tonometry waveform. VAL was determined as the relationship of derived aortic pressure to CMR aortic flow in frequency domain (central illustration).

Results:
Twenty patients (age 80 ± 9 years; 12 males; blood pressure 140/75 ± 20 mmHg) with aortic stenosis on transthoracic echocardiogram (16 severe; mean gradient 45 ± 16 mmHg; aortic valve area 0.8 ± 0.2 cm2) were enrolled. Derived aortic pressure and flow waveforms correlated well with invasive data. Increased VAL was significantly associated with advanced age (P = 0.04) and raised SBP (P < 0.01), irrespective of aortic stenosis severity.

Conclusion:
Difficulties in the measurement and accuracy of ventriculo-arterial coupling means that it is not routinely measured in patients with aortic stenosis. We describe a new noninvasive index that provides an accurate assessment of valvular and arterial load on the left ventricle. VAL may help detect those at risk of ventriculo-arterial coupling mismatch and assist in selection of those most likely to benefit from an invasive procedure.
Excess pressure as an analogue of blood flow velocity
Authors: Armstrong Matthew K. , Schultz Martin G. , Hughes Alun D. , Picone Dean S. , Black J. Andrew , Dwyer Nathan , Roberts-Thomson Philip , Sharman James E. 
Published: October 2020

Introduction:
Derivation of blood flow velocity from a blood pressure waveform is a novel technique, which could have potential clinical importance. Excess pressure, calculated from the blood pressure waveform via the reservoir-excess pressure model, is purported to be an analogue of blood flow velocity but this has never been examined in detail, which was the aim of this study.

Methods:
Intra-arterial blood pressure was measured sequentially at the brachial and radial arteries via fluid-filled catheter simultaneously with blood flow velocity waveforms recorded via Doppler ultrasound on the contralateral arm (n = 98, aged 61 ± 10 years, 72% men). Excess pressure was derived from intra-arterial blood pressure waveforms using pressure-only reservoir-excess pressure analysis.

Results:
Brachial and radial blood flow velocity waveform morphology were closely approximated by excess pressure derived from their respective sites of measurement (median cross-correlation coefficient r = 0.96 and r = 0.95 for brachial and radial comparisons, respectively). In frequency analyses, coherence between blood flow velocity and excess pressure was similar for brachial and radial artery comparisons (brachial and radial median coherence = 0.93 and 0.92, respectively). Brachial and radial blood flow velocity pulse heights were correlated with their respective excess pressure pulse heights (r = 0.53, P < 0.001 and r = 0.43, P < 0.001, respectively).

Conclusion:
Excess pressure is an analogue of blood flow velocity, thus affording the opportunity to derive potentially important information related to arterial blood flow using only the blood pressure waveform.