bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highlights of the 12th InternationalBordetellaSymposium
Authors: Locht Camille , Carbonetti Nicholas H , Cherry James D , Damron F Heath , Edwards Kathryn M , Fernandez Rachel , Harvill Eric T , Hozbor Daniela , Mills Kingston H G , Rodriguez Maria Eugenia , Mascart Françoise 
Published: May 2020

AbstractTo commemorate the 100th anniversary of the Nobel prize being awarded to Jules Bordet, the discoverer of Bordetella pertussis, the 12th International Bordetella Symposium was held from 9 to 12 April 2019 at the Université Libre de Bruxelles, where Jules Bordet studied and was Professor of Microbiology. The symposium attracted more than 300 Bordetella experts from 34 countries. They discussed the latest epidemiologic data and clinical aspects of pertussis, Bordetella biology and pathogenesis, immunology and vaccine development, and genomics and evolution. Advanced technological and methodological tools provided novel insights into the genomic diversity of Bordetella and a better understanding of pertussis disease and vaccine performance. New molecular approaches revealed previously unrecognized complexity of virulence gene regulation. Innovative insights into the immune responses to infection by Bordetella resulted in the development of new vaccine candidates. Such discoveries will aid in the design of more effective approaches to control pertussis and other Bordetella-related diseases.
National trends in healthcare outcomes and utilization of endoscopic and surgical interventions in patients hospitalized with esophageal foreign body and food impaction
Authors: Parikh Malav P , Garg Rajat , Gupta Niyati , Sarvepalli Shashank , Singhal Akhil , Lopez Rocio , Thota Prashanthi N , Sanaka Madhusudhan R 
Published: May 2020

SummaryThe incidence and number of emergency room visits for esophageal foreign body and food impaction (EFB) are on the rise. However, its impact on the rate of inpatient admissions, utilization of endoscopic and surgical interventions, and healthcare outcomes is poorly understood. We conducted a study to analyze these outcomes using the national inpatient sample (NIS) database. Data on all adult patients (≥18 years) admitted with EFB was extracted from the NIS database from 1998 to 2013. The temporal trends in discharge rates as well as in length of stay (LOS), hospital charges, and in-hospital mortality rates were assessed by linear and polynomial regression. Average age, gender, and race of inpatients with EFB were not significantly different between 1998 and 2013. The rate of EFB admissions increased significantly from 1998 to 2005 followed by a decline thereafter (p = 0.01). LOS and hospital charges significantly increased by 0.02 days/year (p = 0.015) and $1,547/year (p &lt; 0.001), respectively. There was a trend towards less utilization of overall esophagogastroduodenoscopy (EGD) over the last decade with significant lower use of EGD within 24 hours in 2013 as compared to 1998 (p = 0.026). The rates of surgical intervention and inpatient mortality did not change significantly over the study period. The rate of inpatient admissions for EFB is on the decline in recent years, suggesting the modern-day practice of cost-effective medicine. Hospitalization costs for EFB have increased, whereas rates of surgical intervention and inpatient mortality have not changed significantly over the study period.
Transdiaphragmatic herniation after transthoracic esophagectomy: an underestimated problem
Authors: Fuchs Hans F , Knepper Laura , Müller Dolores T , Bartella Isabel , Bruns Christiane J , Leers Jessica M , Schröder Wolfgang 
Published: May 2020

Summary
Diaphragmatic transposition of intestinal organs is a major complication after esophagectomy and can be associated with significant morbidity and mortality. This study aims of to analyze a large series of patients with this condition in a single high-volume center for esophageal surgery and to suggest a novel treatment algorithm. Patients who received surgery for postesophagectomy diaphragmatic herniation between October 2003 and December 2017 were included. Retrospective analysis of demographic, clinical and surgical data was performed. Outcomes of measure were initial clinical presentation, postoperative complications, in-hospital mortality and herniation recurrence. A total of 39 patients who had surgery for postesophagectomy diaphragmatic herniation were identified. Diaphragmatic herniation occurred after a median time of 259 days following esophagectomy with the highest prevalence between 1 and 12 months. A total of 84.6% of the patients had neoadjuvant radiochemotherapy prior to esophagectomy. The predominantly effected organ was the transverse colon (87.2%) prolapsing into the left hemithorax (81.6%). A total of 20 patients required emergency surgery. Surgery always consisted of reposition of the intestinal organs and closure of the hiatal orifice; a laparoscopic approach was used in 25.6%. Major complications (Dindo–Clavien ≥ IIIb) were observed in 35.9%, hospital mortality rate was 7.7%. Three patients developed recurrent diaphragmatic herniation during follow-up. Postesophagectomy diaphragmatic herniation is a functional complication of the late postoperative course and predominantly occurs in patients with locally advanced adenocarcinoma having chemoradiation before Ivor–Lewis esophagectomy. Due to a high rate of emergency surgery with life-threatening complications not a ‘wait-and-see’ strategy but early surgical repair may be indicated.
Subtypes of Late-Life Depression: A Data-Driven Approach on Cognitive Domains and Physical Frailty
Authors: Lugtenburg Astrid , Zuidersma Marij , Wardenaar Klaas J , Aprahamian Ivan , Rhebergen Didi , Schoevers Robert A , Oude Voshaar Richard C 
Published: May 2020

Abstract

Background
With increasing age, symptoms of depression may increasingly overlap with age-related physical frailty and cognitive decline. We aim to identify late-life-related subtypes of depression based on measures of depressive symptom dimensions, cognitive performance, and physical frailty.

Methods
A clinical cohort study of 375 depressed older patients with a DSM-IV depressive disorder (acronym NESDO). A latent profile analysis was applied on the three subscales of the Inventory of Depressive Symptomatology, as well as performance in five cognitive domains and two proxies for physical frailty. For each class, we investigated remission, dropout, and mortality at 2-year follow-up as well as change over time of depressive symptom severity, cognitive performance, and physical frailty.

Results
A latent profile analysis model with five classes best described the data, yielding two subgroups suffering from pure depression (“mild” and “severe” depression, 55% of all patients) and three subgroups characterized by a specific profile of cognitive and physical frailty features, labeled as “amnestic depression,” “frail-depressed, physically dominated,” and “frail-depressed, cognitively dominated.” The prospective analyses showed that patients in the subgroup of “mild depression” and “amnestic depression” had the highest remission rates, whereas patients in both frail-depressed subgroups had the highest mortality rates.

Conclusions
Late-life depression can be subtyped by specific combinations of age-related clinical features, which seems to have prospective relevance. Subtyping according to the cognitive profile and physical frailty may be relevant for studies examining underlying disease processes as well as to stratify treatment studies on the effectiveness of antidepressants, psychotherapy, and augmentation with geriatric rehabilitation.
A Systematic Review and Meta-Analysis of Subjective Age and the Association With Cognition, Subjective Well-Being, and Depression
Authors: Alonso Debreczeni Felicia , Bailey Phoebe E 
Published: May 2020

Abstract

Objectives
A systematic review and meta-analysis were conducted to quantify the degree to which subjective age is associated with cognition, subjective well-being, and depression.

Method
A systematic search was performed in three electronic social scientific databases, PsycINFO, Scopus, and Web of Science in May 2018. A manual forward and backward citation search of articles meeting the criteria for inclusion, including a mean participant age of 40+ years, was conducted in November 2019. Twenty-four independent data sets were included in the meta-analysis.

Results
Overall, a younger subjective age was related to enhanced subjective well-being and cognitive performance, and reduced depressive symptoms (r = .18). This association was stronger among collectivist (r = .24) than individualist (r = .16) cultures. Mean chronological age across samples (ranging from 55 to 83 years), type of subjective age scoring, and gender did not influence the strength of the overall association. Further analysis revealed that subjective age was individually associated with depressive symptoms (r = .20), subjective well-being (r = .17), and cognition (r = .14), and none had a stronger association with subjective age than the other.

Discussion
The results indicate a small yet significant association between subjective age and important developmental outcomes.
Effect of wet/dry, fresh liquid, fermented whole diet liquid, and fermented cereal liquid feeding on feed microbial quality and growth in grow-finisher pigs
Authors: O’ Meara Fiona M , Gardiner Gillian E , O’ Doherty John V , Clarke David , Cummins Wayne , Lawlor Peadar G 
Published: May 2020

Abstract
Fermented liquid feeding has proved beneficial for weaner pigs; however, there is limited research on its effect on the growth and feed conversion efficiency (FCE) of grow-finisher pigs. Microbial decarboxylation of amino acids is associated with whole diet fermentation, while wet/dry and liquid feeding reportedly improve growth compared with dry feeding. The objective of this study was to determine the effect of wet/dry feeding and fresh, fermented whole diet, and fermented cereal liquid feeding on pig growth, feed efficiency, and carcass quality in grow-finisher pigs. Pigs were allocated to one of four dietary treatments in two experiments: 1) Single-space wet/dry feeders (WET/DRY), 2) Fresh liquid feeding (FRESH), 3) Fermented cereal liquid feeding where the cereal fraction (38% barley, 40% wheat) of the diet was fermented prior to feeding (FERM-CER), and 4) Fermented whole diet liquid feeding where the whole diet was fermented prior to feeding (FERM-WH). In exp. 1, pigs were fed the experimental diets for 68 d prior to slaughter (29.8 kg ± 0.92 SE to 102.3 kg ± 0.76 SE). Overall, average daily gain (ADG) was 1,094, 1,088, 1,110, and 955 g/d (SE = 13.0; P &lt; 0.001) and FCE was 2.26, 2.37, 2.40, and 2.88 (SE = 0.031; P &lt; 0.001) for treatments one through four, respectively. Pigs fed FERM-WH were lighter at slaughter than pigs fed the other three treatments (P &lt; 0.001). In exp. 2, pigs were on treatment for 26 d prior to slaughter (85.3 kg ± 1.69 SE to 117.5 kg ± 0.72 SE). Overall, ADG in exp. 2 was 1,103, 1,217, 1,284, and 1,140 g/d (SE = 27.9; P &lt; 0.01) and FCE was 2.78, 2.99, 2.95, and 3.09 g/g (SE = 0.071; P = 0.05), for treatments one through four, respectively. There were no significant differences observed between treatments for apparent total tract digestibility of dry matter, organic matter, nitrogen, gross energy, or ash. Higher lactic acid bacteria counts and lower Enterobacteriaceae counts and pH were observed in FERM-CER and FERM-WH compared with WET/DRY and FRESH. Ethanol concentrations were almost 4-fold higher in FERM-CER troughs than FRESH troughs and 5-fold higher in FERM-WH than FRESH troughs. To conclude, FERM-WH resulted in poorer growth and FCE compared with WET/DRY, FRESH, and FERM-CER, probably due to amino acid degradation and a loss in gross energy found in FERM-WH.
Review of Mites Found on Various Animal Hosts and at Different Localities in Malaysia
Authors: Azmiera N , Mariana A , Pimsler M L , Heo C C 
Published: May 2020

AbstractMite biodiversity and distribution in Malaysia is currently understudied. Most previous works on Malaysian Acari have focused on pest organisms of medical, veterinary, and agricultural concern, with a few recent studies centered on mites in forensic contexts. Previous literatures have targeted collection sites in forest reserves and/or mountains in either Peninsular or Malaysian Borneo, though the state of Sarawak had the least publications related to mite species descriptions despite having the highest number of nature parks of any state in the country. Most publications focused on the three states Selangor, Pahang and Sabah. Most of the mite species reported were from mammals (66.3%), with fewer species from birds (21.7%), arthropods (11.2%), and reptiles (0.8%). We believe that further work on the systematic documentation of mite species throughout Malaysia is necessary as it could generate useful tools, such as the use of mites as biogeographical markers or as forensic indicators. Therefore, this review catalogs mite species that have been documented in or on animal hosts in Malaysia and serves as a foundation for future work.
Standardization of a Culture Medium for Megaselia scalaris (Diptera: Phoridae) for Entomotoxicological Studies
Authors: Castillo-Alanis Luz Alejandra , González-Hernández Ana Edith , Quijano-Mateos Alejandra , Pedraza-Lara Carlos Salvador , Villavicencio-Queijeiro Alexa , Bravo-Gómez María Elena 
Published: May 2020

AbstractOne of the problems faced by entomotoxicological studies is the large variability of experimental set-ups and the absence of harmonized protocols to compare the data and results obtained by different research groups. Among the wide range of influencing factors on the development and growth of insects, food substrates are remarkably relevant. This article proposes a standardized growth medium to be employed in future entomotoxicological studies on the scuttle fly Megaselia scalaris (Loew, 1866), (Diptera: Phoridae). This species plays an important role in forensic cases related to the decomposition of human remains found indoors and/or in concealed environments, because of their small size and ability to enter these locations at an earlier time than many other insects. Because of these traits, it can be used for the estimation of the minimum postmortem interval (mPMI). We achieved the formulation of a medium that overcomes two traditional disadvantages of culture media used to raise necrophagous Diptera, the unknown media composition and different growth rates from those reared in tissue. The proposed medium is a known composition formulation, free of xenobiotics, in which M. scalaris shows growth rates and development times similar to those obtained when it is reared in tissue. This new diet might be used in future studies to test the effect of substances of forensic interest (prescription or illicit drugs, poisons, etc.) on the larval development time, helping to adjust the estimation of mPMI based on the presence of such substances. Additionally, the formulation revealed some interesting data about nutritional requirements of this species.
Carbon-loud SDSS BOSS type II quasars at z &gt; 2: high-density gas or secondary production of carbon?
Authors: Silva M , Humphrey A , Lagos P , Morais S G 
Published: May 2020

ABSTRACT
We study the ultraviolet (UV) emission-line ratios of a sample of 145 type II quasars (QSO2s) from Sloan Digital Sky Survey iii Baryon Oscillation Spectroscopic Survey, and compare against a grid of active galactic nucleus (AGN) photoionization models with a range in gas density, gas chemical abundances, and ionization parameter. Most of the quasars are ‘carbon-loud’, with C  iv/He ii ratios that are unusually high for the narrow-line region, implying higher than expected gas density (&gt;106 cm−3) and/or significantly supersolar-relative carbon abundance. We also find that solar or supersolar nitrogen abundance and metallicity are required in the majority of our sample, with potentially significant variation between objects. Compared to radio galaxies at similar redshifts (HzRGs; z &gt; 2), the QSO2s are offset to higher N  v/He ii, C  iv/He ii, and C iii]/He ii, suggesting systematically higher gas density and/or systematically higher C and N abundances. We find no evidence for a systematic difference in the N/C abundance ratio between the two types of objects. Scatter in the N  iv]/C  iv ratio implies a significant scatter in the N/C abundance ratio among the QSO2s and HzRGs, consistent with differences in the chemical enrichment histories between objects. Interestingly, we find that adopting secondary behaviour for both N and C alleviates the long-standing ‘N  iv] problem’. A subset of the QSO2s and HzRGs also appear to be ‘silicon-loud’, with Si iii] relative fluxes suggesting Si/C and Si/O are an order of magnitude above their solar values. Finally, we propose new UV-line criteria to select genuine QSO2s with low-density narrow-line regions.
The MOSDEF-LRIS Survey: The Interplay Between Massive Stars and Ionized Gas in High-Redshift Star-Forming Galaxies1
Authors: Topping Michael W , Shapley Alice E , Reddy Naveen A , Sanders Ryan L , Coil Alison L , Kriek Mariska , Mobasher Bahram , Siana Brian 
Published: May 2020

Abstract
We present a joint analysis of rest-UV and rest-optical spectra obtained using Keck/LRIS and Keck/MOSFIRE for a sample of 62 star-forming galaxies at z ∼ 2.3. We divide our sample into two bins based on their location in the [OIII]5007/Hβ vs. [NII]6584/Hα BPT diagram, and perform the first differential study of the rest-UV properties of massive ionizing stars as a function of rest-optical emission-line ratios. Fitting BPASS stellar population synthesis models, including nebular continuum emission, to our rest-UV composite spectra, we find that high-redshift galaxies offset towards higher [OIII]λ5007/Hβ and [NII]λ6584/Hα have younger ages ($\log (\textrm {~Age/yr})=7.20^{+0.57}_{-0.20}$) and lower stellar metallicities ($Z_*=0.0010^{+0.0011}_{-0.0003}$) resulting in a harder ionizing spectrum, compared to the galaxies in our sample that lie on the local BPT star-forming sequence ($\log (\textrm {Age/yr})=8.57^{+0.88}_{-0.84}$, $Z_*=0.0019^{+0.0006}_{-0.0006}$). Additionally, we find that the offset galaxies have an ionization parameter of $\log (U)=-3.04^{+0.06}_{-0.11}$ and nebular metallicity of ($12+\log (\textrm {~O/H})=8.40^{+0.06}_{-0.07}$), and the non-offset galaxies have an ionization parameter of $\log (U)=-3.11^{+0.08}_{-0.08}$ and nebular metallicity of $12+\log (\textrm {~O/H})=8.30^{+0.05}_{-0.06}$. The stellar and nebular metallicities derived for our sample imply that the galaxies offset from the local BPT relation are more α-enhanced ($7.28^{+2.52}_{-2.82}\textrm {~O/Fe}_{\odot }$) compared to those consistent with the local sequence ($3.04^{+0.95}_{-0.54}\textrm {~O/Fe}_{\odot }$). However, even galaxies that are entirely consistent with the local nebular excitation sequence appear to be α-enhanced – in contrast with typical local systems. Such differences must be considered when estimating gas-phase oxygen abundances at high redshift based on strong emission-line ratios. Specifically, a similarity in the location of high-redshift and local galaxies in the BPT diagram may not be indicative of a similarity in their physical properties.
Resonant damping and instability of propagating kink waves in flowing and twisted magnetic flux tubes
Authors: Bahari K , Petrukhin N S , Ruderman M S 
Published: May 2020

ABSTRACT
We study the propagation and stability of kink waves in a twisted magnetic tube with the flow. The flow velocity is assumed to be parallel to the magnetic field, and the magnetic field lines are straight outside the tube. The density is constant inside and outside of the tube, and it monotonically decreases from its value inside the tube to that outside in the transitional or boundary layer. The flow speed and magnetic twist monotonically decrease in the transitional layer from their values inside the tube to zero outside. Using the thin tube and thin boundary layer (TTTB) approximation, we derived the dispersion equation determining the dependence of the wave frequency and decrement/increment on the wavenumber. When the kink wave frequency coincides with the local Alfvén frequency at a resonant surface inside the transitional layer, the kink wave is subjected to either resonant damping or resonant instability. We study the properties of kink waves in a particular unperturbed state where there is no flow and magnetic twist in the transitional layer. It is shown that in a tube with flow, the kink waves can propagate without damping for particular values of the flow speed. Kink waves propagating in the flow direction either damp or propagate without damping. Waves propagating in the opposite direction can either propagate without damping, or damp, or become unstable. The theoretical results are applied to the problem of excitation of kink waves in spicules and filaments in the solar atmosphere.
miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology
Authors: Chang Le , Zhou Guangyan , Soufan Othman , Xia Jianguo 
Published: May 2020

Abstract
miRNet is an easy-to-use, web-based platform designed to help elucidate microRNA (miRNA) functions by integrating users' data with existing knowledge via network-based visual analytics. Since its first release in 2016, miRNet has been accessed by &gt;20 000 researchers worldwide, with ∼100 users on a daily basis. While version 1.0 was focused primarily on miRNA-target gene interactions, it has become clear that in order to obtain a global view of miRNA functions, it is necessary to bring other important players into the context during analysis. Driven by this concept, in miRNet version 2.0, we have (i) added support for transcription factors (TFs) and single nucleotide polymorphisms (SNPs) that affect miRNAs, miRNA-binding sites or target genes, whilst also greatly increased (&gt;5-fold) the underlying knowledgebases of miRNAs, ncRNAs and disease associations; (ii) implemented new functions to allow creation and visual exploration of multipartite networks, with enhanced support for in situ functional analysis and (iii) revamped the web interface, optimized the workflow, and introduced microservices and web application programming interface (API) to sustain high-performance, real-time data analysis. The underlying R package is also released in tandem with version 2.0 to allow more flexible data analysis for R programmers. The miRNet 2.0 website is freely available at https://www.mirnet.ca.
A report of two challenging cases of bone infection: Mycobacterium tuberculosis. How to manage?
Authors: Elghoul Naoufal , Benchakroun Mohammed , Zaddoug Omar , Bennis Azzelarab , Zine Ali , Tanane Mansour , Jaafar Abdeloihab 
Published: May 2020

AbstractThe incidence of bone tuberculosis is less than 5% of all tuberculosis cases. Furthermore, multifocal bone tuberculosis is uncommon, which rarely occurs without primary foci. It is difficult to diagnose, particularly if it is localized in both humeral heads. On the other hand, the isolated iliac bone tuberculosis is exceptional; it constitutes, also, a challenging diagnosis, which requires a high index of clinical suspicion and advanced investigations. Herein, we first report a case of multifocal tuberculosis of both humeral heads with no primary foci, and we secondarily report a case of isolated iliac bone tuberculosis. At last, however, the histological exam and polymerase chain reaction for the Mycobacterium tuberculosis complex are not always positives; they are mandatory as tests to ascertain the diagnosis.