bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF TEMPERATURE IN TETRADESMUS OBLIQUUS
Authors: Nishimura T. , Rampi M. G. , Martins L. S. , Vieira R. B. , Vargas J. V. C. , Mariano A. B. 
Published: December 2020

The ever growing demand of energy generation and distribution has been one of the concerns of governments and the focus of research institutions. Likewise, how to supply the energy demands necessary for the development of nations having the lowest environmental impact possible has also been studied. Biofuels have been pointed out as an alternative for that energy challenge, since their use reduce the carbon footprint of industries and vehicles. Biofuels can be obtained from microalgae with the advantage of not competing for space with corn, sugar cane or other crops for food industry. Even though attractive, the biofuel production from microalgae presents some challenges, as for example the separation process required to obtain microalgae biomass. The culture is very diluted and the dewatering must be efficient, low cost and cause no damage to the cell. With the intent to address this issue, the herein paper presents a study of an alternative way to increase flocculation efficiency according to the temperature of the culture with the potential to improve the filtration efficiency in a continuous process. An increasing in the flocculation temperature from 20°C to 60°C increased the flocculation efficiency from 97.79% to 98.64%, using ferric chloride as a flocculant agent.
Traversées féminines de l’Atlantique noir, dans des œuvres de Fabienne Kanor et de Léonora Miano
Authors: Unter Ecker Marjolaine 
Published: December 2020

Fabienne Kanor et Léonora Miano, auteures afro-descendantes d’expression française, explorent dans leurs œuvres l’Atlantique noir (Gilroy, 1993). Celui-ci dépasse les frontières traditionnellement établies, puisque s’y produisent de nombreuses circulations et que les identités et les cultures qui s’y déploient se définissent par l’hybridité ; aussi, on peut s’interroger sur les capacités émancipatrices que cet espace propose pour les catégories de races et de genres. C’est ce que cet article se propose d’étudier, à travers une étude littéraire portant sur un corpus constitué d’un recueil de textes pour la scène, Red in blue trilogie (Miano, 2015) et d’un roman, Humus (Kanor, 2006). Ceux-ci re-localisent les discours historiques sur l’esclavage, notamment en les ancrant dans les récits des vécus et des expériences intimes de personnages féminins, participant de ce fait du projet de « contre-culture de la modernité » qu’est celui de l’Atlantique noir.
Non‐Bonding 1,4‐Sulphur‐Oxygen Interaction Governs the Reactivity of α‐Ketothioesters in Triphenylphosphine‐Catalyzed Cyclization with Acetylenedicarboxylates
Authors: Bankura Abhijit , Saha Jayanta , Maity Rajib , Das Indrajit 
Published: December 2020

Abstractα‐Ketothioesters undergo triphenylphosphine (PPh3)‐catalyzed cyclization with acetylenedicarboxylate esters smoothly, in contrast to α‐ketooxoesters which require more drastic conditions with the limited substrate scope. The reaction works well with a wide range of α‐ketothioesters, delivering highly functionalized α,β‐unsaturated γ‐butyrolactones in moderate to excellent yields. The higher reactivity of the thioester derivatives is seemingly due to a favourable intramolecular non‐bonding electrostatic 1,4‐interaction involving C−S σ* orbital on the sulphur atom and the lone pair of electrons in the electron‐donating oxygen atom. This is apparent from the X‐ray crystallographically determined internuclear distance between the sulphur and ketone (C=O) oxygen atoms (2.71–2.85 Å), which is significantly less than the sum of their van der Waals radii (3.25–3.30 Å). The substitution on the S atom is oriented diametrically away from the ketone O atom to maximize the interaction between them. The trend is also seen in the 1,4‐S⋅⋅⋅O contact between the S and furan O atoms (2.70 Å) in the γ‐butyrolactone products.magnified image
Formation of FeOOH Nanosheets Induces Substitutional Doping of CeO2−x with High‐Valence Ni for Efficient Water Oxidation
Authors: Yu Jun , Wang Jian , Long Xia , Chen Lei , Cao Qi , Wang Jian , Qiu Chen , Lim Jongwoo , Yang Shihe 
Published: December 2020

AbstractTransition metal elements such as Ni in high oxidation states can promote oxygen evolution reaction (OER) activity, but it is difficult to prepare dispersed Ni3+ or even Ni4+ species under mild conditions. Herein, a one‐step synthesis of high‐valence nickel‐doped CeO2−x covered with FeOOH nanosheets in the presence of Ni2+/Fe3+ is reported. A series of ex situ and in situ experiments reveal the etching effect on ceria of the H+ species from the hydrolysis of Fe3+, which induces substitutional doping of Ni2+ ions into the etched sites and their further oxidation to the high‐valance Ni3+/Ni4+ by coupling to the Ce4+/Ce3+ pair in the oxygen‐vacancy‐rich CeO2−x. Concomitantly, Fe3+ is deposited on the surface of ceria as FeOOH nanosheets. The dispersed high‐valent Ni3+/Ni4+ coupled with the decorated FeOOH nanosheets on CeO2−x leads to efficient OER electrocatalysis with a low overpotential of 195 mV cm−2 at a current density of 10 mA cm−2 and a high turnover frequency (TOF) of 0.99 s−1, which, to the best of the authors’ knowledge represents the best Ce‐containing OER catalyst reported to date, and comparable to other top OER catalysts. This work opens an avenue for engineering high‐valence metal ions in an oxide matrix for the OER or other oxidation reactions.
Visible‐Light Responsive TiO2‐Based Materials for Efficient Solar Energy Utilization
Authors: Zhang Wei , He Haili , Li Haoze , Duan Linlin , Zu Lianhai , Zhai Yunpu , Li Wei , Wang Lianzhou , Fu Honggang , Zhao Dongyuan 
Published: December 2020

AbstractThe photocatalytic properties of TiO2 have aroused a broad range of research interest since 1972 due to its abundance, chemical stability, and easily available nature. To increase its overall activity, in the past few decades, much effort has been devoted to the fabrication of advanced TiO2‐based photocatalysts with visible‐light response and these photocatalysts have shown great potential in the field of solar energy utilization. Here, recent progress in the investigation of visible‐light responsive TiO2‐based materials are reviewed. Notably, the fabrication strategies and corresponding chemical/physical properties of visible‐light responsive TiO2‐based materials are described in detail, with a focus on bandgap engineering and junction engineering from the perspective of light absorption, charge transfer and separation, and surface reactions. Their applications in solar‐fuel production, organic synthesis, bacterial disinfection, pollutant degradation and nitrogen fixation are also discussed. Moreover, the new trends and ongoing challenges in this field are proposed and highlighted.
Sustainable Li‐Ion Batteries: Chemistry and Recycling
Authors: Piątek Jędrzej , Afyon Semih , Budnyak Tetyana M. , Budnyk Serhiy , Sipponen Mika H. , Slabon Adam 
Published: December 2020

AbstractThe commercial breakthrough of Li‐ion batteries (LIBs) in the 1990s irrevocably shaped today's energy storage landscape, but the disposed batteries represent a growing hazard to the environment. One may initially assume that recycling processes are commendable technologies to ensure a counterbalance to LIBs manufacturing. However, the question remains whether current state‐of‐the‐art in LIBs recycling technologies can be considered as green. This problem is due to the application of toxic chemicals or the in situ generation of harmful substances during the recycling process. Besides the potential toxicity, current solutions are accompanied with intense energy consumption, causing carbon dioxide emissions, in disagreement with the circular economy principles. This review provides a critical assessment of both published research articles and patents to derive a broad picture on the sustainability of LIBs recycling technologies. Although the efficiency of industrially applied recycling technologies can exhibit a high overall efficiency, their general process design is generally based on waste reduction and downcycling. Contrariwise, sustainable recycling of LIBs should rely on circular processes ensuring upcycling of all materials toward zero waste and minimized energy utilization. Current solutions and expected development in LIBs recycling are presented, ranging from dismantling over components separation to application of bioderived materials.
Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta‐analysis
Authors: Jafari Aria , von Sneidern Manuela , Lehmann Ashton E. , Shen Sarek A. , Shishido Sachie , Freitag Suzanne K. , Bleier Benjamin S. 
Published: December 2020

BackgroundThe Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) classification system was developed to standardize prospective outcome analysis following orbital cavernous hemangioma (OCH) resection. The goal of this study was to retroactively apply the CHEER system to all prior existing reports of endoscopic resection of primary benign orbital tumors (BOTs) to: (1) compare patient presentations, perioperative characteristics, and outcomes between OCH and other BOTs; and (2) determine whether the CHEER categorization regime could be expanded to other BOTs.MethodsA systematic review of studies reporting exclusively endoscopic resections of OCH and other BOTs (eg, solitary fibrous tumor, schwannoma, and meningioma) was performed. Patient, tumor characteristics, and operative outcomes were recorded. All tumors with adequate reporting were retrospectively assigned a CHEER stage. Outcomes were compared using chi‐square or Fisher's exact tests.ResultsNinety‐three studies met inclusion criteria, and sufficient data were available in 36 studies, comprising 105 tumors (n = 87 OCHs; n = 18 other BOTs). Baseline patient and tumor characteristics, as well as intraoperative and short‐term postoperative outcomes were not significantly different between OCHs and other BOTs. Long‐term outcomes (eg, visual deficits, diplopia, eye position, and recurrence) also did not differ when controlling for CHEER stage.ConclusionThis review represents the largest collection of outcomes data following exclusively endoscopic endonasal resection of BOTs. Short‐term and long‐term outcomes appear similar between OCHs and other BOTs. These results suggest that exclusively endoscopic resection of orbital tumors may be effective in a range of benign pathologies. Furthermore, these results support a broader application of the CHEER system to other benign primary orbital tumors.
Pyramidal weakness: Is it time to retire the term?
Authors: Castle‐Kirszbaum Mendel , Goldschlager Tony 
Published: December 2020

AbstractPyramidal weakness, that is, the weakness that preferentially spares the antigravity muscles, is considered an integral part of the upper motor neuron syndrome. Despite its name, pyramidal weakness has very little to do with the pyramidal tract, and preeminent texts on neurology, neuroanatomy, and clinical examination differ considerably in their descriptions and localization of this enigmatic finding. Evidence from human and nonhuman primate studies demonstrates that lesions confined only to the corticospinal (pyramidal) tract cause significant deficits in fine motor control of the hand, but do not cause posturing or patterned weakness of the extremities. Lesioning of the corticofugal fibers, particularly the corticoreticular and corticopontine tracts, leads to dysbalanced output from reticulospinal, and vestibulospinal systems, which along with changes in rubrospinal tract output balance, probably accounts for the pyramidal weakness pattern. Importantly, this would delineate that pyramidal weakness could only be incited by lesions above the brainstem. It has also been suggested that the inherently greater strength of the antigravity musculature is the substrate for pyramidal weakness, independent of any preferential motor innervation. These hypotheses require further testing in myometric studies with carefully selected participants.
Early hypertension and neutropenia are predictors of treatment efficacy in metastatic colorectal cancer patients administered FOLFIRI and vascular endothelial growth factor inhibitors as second‐line chemotherapy
Authors: Osumi Hiroki , Shinozaki Eiji , Ooki Akira , Wakatsuki Takeru , Kamiimabeppu Daisaku , Sato Taro , Nakayama Izuma , Ogura Mariko , Takahari Daisuke , Chin Keisho , Yamaguchi Kensei 
Published: December 2020

AbstractBackgroundThree vascular endothelial growth factor (VEGF) inhibitors, Bevacizumab (BEV), ramucirumab (RAM), and aflibercept (AFL), are widely used for metastatic colorectal cancer (mCRC) patients who are treated with second‐line chemotherapy. The difference in outcome between the three drugs has not been evaluated. In contrast to epidermal growth factor receptor inhibitors, VEGF inhibitors have few candidate predictors of efficacy.MethodsConsecutive mCRC patients who were treated with second‐line chemotherapy were retrospectively enrolled. Overall response rate (ORR), progression‐free survival (PFS), overall survival (OS), and safety were assessed. Subgroup analyses of prognostic and predictive efficacy markers were performed.ResultsA total of 119 (41.2%), 107 (37.0%), and 63 patients (21.8%) were treated with FOLFIRI +BEV, RAM, or AFL, respectively. ORR, PFS, and OS showed no significant differences between three groups. However, the frequency of grade 3 or 4 adverse events (AEs) in the FOLFIRI +AFL group was significantly higher than that in the other groups (p < 0.001). Patients with grade 3 or 4 AEs, especially hypertension and neutropenia within the first four cycles of treatment had significantly longer PFS and OS than those without AEs, irrespective of treatment with VEGF inhibitors (p < 0.001). PFS in patients without prior BEV exposure was also significantly longer than that in patients with prior BEV exposure (p = 0.003).ConclusionsChemotherapeutic efficacy did not differ between the groups. Grade 3 or 4 AEs within the first four cycles of treatment and prior BEV exposure may be an effective predictor of treatment efficacy in mCRC patients administered VEGF inhibitors as second‐line chemotherapy.
Dedicated plug based closure for large bore access –The MARVEL prospective registry
Authors: Kroon Herbert G. , Tonino Pim A.L. , Savontaus Mikko , Amoroso Giovanni , Laine Mika , Christiansen Evald H. , Toggweiler Stefan , ten Berg Jur , Sathananthan Janarthanan , Daemen Joost , de Jaegere Peter P. , Brueren Guus B.R.G. , Malmberg Markus , Slagboom Ton , Moriyama Noriaki , Terkelsen Christian J. , Moccetti Federico , Gheorghe Livia , Webb John , Wood David , Van Mieghem Nicolas M. 
Published: December 2020

AbstractObjectivesTo study safety and performance of the MANTA Vascular closure device (VCD) under real world conditions in 10 centers.BackgroundThe MANTA is a novel plug‐based device for large bore arteriotomy closure.MethodsWe included all eligible patients who underwent transfemoral large bore percutaneous procedures. Exclusion criteria were per operator's discretion and included severe calcification or marked tortuosity of the access vessel, presence of marked obesity/cachexia or a systolic blood pressure above 180 mmHg. The primary performance endpoint was time to hemostasis. Primary and secondary safety endpoints were major and minor access site related vascular complications up to 30 days, respectively. Vascular complications were adjudicated by an independent clinical event committee according to VARC‐2 criteria. We performed multivariable logistic regression to estimate the effect of baseline and procedural characteristics on any and major vascular complications.ResultsBetween February 2018 and July 2019 500 patients were enrolled undergoing Transcatheter aortic valve replacement (TAVR, N = 496), Balloon aortic valvuloplasty (BAV, N = 2), Mechanical circulatory support (MCS, N = 1) or Endovascular aneurysm repair (EVAR, N = 1). Mean age was 80.8 ± 6.6 years with a median STS‐score of 2.7 [IQR 2.0–4.3] %. MANTA access site complications were major in 20 (4%) and minor in 28 patients (5.6%). Median time to hemostasis was 50 [IQR 20–120] sec. Severe femoral artery calcification, scar presence in groin, longer procedure duration, female gender and history of hypertension were independent predictors for vascular complications.ConclusionIn this study, MANTA appeared to be a safe and effective device for large bore access closure under real‐world conditions.
Beyond the dyad: the role of mother and father in newborns’ global DNA methylation during the first month of life—a pilot study
Authors: Pellicano Gaia Romana , Carola Valeria , Bussone Silvia , Cecchini Marco , Tambelli Renata , Lai Carlo 
Published: December 2020

AbstractThe study aimed to longitudinally explore the effects of parental prenatal attachment and psychopathological symptomatology on neonatal global DNA methylation (5‐mC) variation between birth and the first month of life. Eighteen mothers and thirteen fathers were assessed before childbirth (t0) by Perceived Stress Scale (PSS), Prenatal‐Attachment Inventory, and Paternal Antenatal Attachment Scale; 48 hr after childbirth (t1) by SCL‐90‐R; and one month after childbirth (t2) by PSS. At t1 and t2, buccal swabs from parents and newborns were collected. In newborns’ 5‐mC and single nucleotide polymorphisms (SNPs) of DAT, MAOA, BDNF, and 5‐HTTLPR genes were detected, while in parents only SNPs were measured. At t1, newborns’ 5‐mC was negatively associated with maternal psychopathological symptoms, while at t2, newborns’ 5‐mC was positively associated with paternal psychopathological symptoms and negatively with paternal prenatal attachment. The variation of newborns’ 5‐mC from t1 to t2 was predicted by paternal psychopathological symptoms. No significant correlations among parental SNPs and 5‐mC levels were found. Results highlight parent‐specific influences on newborn's DNA methylation. At birth, maternal psychological symptoms seem to have an effect on newborns’ 5‐mC, while after one month of life, paternal psychological characteristics could have a specific role in modulating the newborns’ epigenetic responses to the environment.
Severe limitations of the FEve metric of functional evenness and some alternative metrics
Authors: Kosman Evsey , Scheiner Samuel M. , Gregorius Hans‐Rolf 
Published: December 2020

AbstractThe metric of functional evenness FEve is an example of how approaches to conceptualizing and measuring functional variability may go astray. This index has several critical conceptual and practical drawbacks:

Different values of the FEve index for the same community can be obtained if the species have unequal species abundances; this result is highly likely if most of the traits are categorical.
Very minor differences in even one pairwise distance can result in very different values of FEve.
FEve uses only a fraction of the information contained in the matrix of species distances. Counterintuitively, this can cause very similar FEve scores for communities with substantially different patterns of species dispersal in trait space.
FEve is a valid metric only if all species have exactly the same abundances. However, the meaning of FEve in such an instance is unclear as the purpose of the metric is to measure the variability of abundances in trait space.
We recommend not using the FEve metric in studies of functional variability. Given the wide usage of FEve index over the last decade, the validity of the conclusions based on those estimates is in question. Instead, we suggest three alternative metrics that combine variability in species distances in trait space with abundance in various ways. More broadly, we recommend that researchers think about which community properties (e.g., trait distances of a focus species to the nearest neighbor or all other species, variability of pairwise interactions between species) they want to measure and pick from among the appropriate metrics.
Improved freshwater macroinvertebrate detection from environmental DNA through minimized nontarget amplification
Authors: Leese Florian , Sander Mandy , Buchner Dominik , Elbrecht Vasco , Haase Peter , Zizka Vera M. A. 
Published: December 2020

AbstractDNA metabarcoding of freshwater communities typically relies on PCR amplification of a fragment of the mitochondrial cytochrome c oxidase I (COI) gene with degenerate primers. The advantage of COI is its taxonomic resolution and the availability of an extensive reference database. However, when universal primers are used on environmental DNA (eDNA) isolated from water, benthic invertebrate read and OTU numbers are typically “watered down,” that is, under represented, compared to whole specimen “bulk samples” due to greater co‐amplification of abundant nontarget taxa (e.g., fungi, algae, and bacteria). Because benthic stream invertebrate taxa are of prime importance for regulatory biomonitoring, more effective ways to capture their diversity via eDNA isolated from water are important. In this study, we aimed to improve benthic invertebrate assessment from eDNA by minimizing nontarget amplification. Therefore, we generated eDNA data using universal primers BF2/BR2 on samples collected throughout 15 months from a German Long‐Term Ecological Research site (Rhine‐Main‐Observatory, Kinzig River) to identify most abundant nontarget taxa. Based on these data, we designed a new reverse primer (EPTDr2n) with 3’‐specificity toward benthic invertebrate taxa and validated its specificity in silico together with universal forward primer fwhF2 using available data from GenBank and BOLD. We then performed in situ tests using 20 Kinzig River eDNA samples. We found that the percentage of target reads was much higher for the new primer combination compared to two universal benthic invertebrate primer pairs, BF2/BR2 and fwhF2/fwhR2n (99.6% versus 25.89% and 39.04%, respectively). Likewise, the number of detected benthic invertebrate species was substantially higher (305 versus 113 and 185) and exceeded the number of 153 species identified by expert taxonomists at nearby sites across two decades of sampling. While few taxa, such as flatworms, were not detected, we show that the optimized primer avoids the nontarget amplification bias and thus significantly improves benthic invertebrate detection from eDNA.
Autophagy regulates long‐term cross‐presentation by murine dendritic cells
Authors: Ho Nataschja I. , Camps Marcel G. M. , Verdoes Martijn , Münz Christian , Ossendorp Ferry 
Published: December 2020

AbstractAutophagy has been reported to be involved in supporting antigen cross‐presentation by dendritic cells (DCs). We have shown that DCs have the ability to store antigen for a prolonged time in endolysosomal compartments and thereby sustain MHCI antigen cross‐presentation to CD8+ T cells. In the current study, we investigated the role of autophagy in long‐term antigen presentation. We show that the autophagy machinery has a negative impact on storage of antigen in DCs. Atg5–/–DCs which are deficient in autophagy or DCs treated with common autophagy inhibitors showed enhanced antigen storage and antigen cross‐presentation. This augmented antigen cross‐presentation effect is independent of altered proteasome enzyme activity or MHCI surface expression on DCs. We visualized that the storage compartments are in close proximity to LC3 positive autophagosomes. Our results indicate that autophagosomes disrupt antigen storage in DCs and thereby regulate long‐term MHCI cross‐presentation.