bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Results Of Joint-Preserving Surgery In Paediatric Leg Sarcoma Using 3D Digital Planning And Navigation/3D-Printed Resection Guides
Authors: Wong Kwok-Chuen , Wong Christie On-Yiu , Kumta Shekhar Madhukar 
Published: December 2024

IntroductionJoint-preserving tumor resection and patient-specific implant (PSI) reconstruction have the advantages of retaining the function and growth of native joints. Long-term complications of PSI in young active patients were a concern [1]. 3D planning and assistive tools like Navigation (NAVI) or 3D-printed guides (PSG) may facilitate the technically demanding surgical procedures [2,3] as it is challenging to translate the surgical plan with a negative surgical margin and match it to the PSI.MethodsWe treated 20 paediatric and adolescent patients with lower extremity bone sarcoma who underwent joint-preserving tumor resection and extendable PSI (2006 and 2019). The mean age was 11 (5-17). Engineers designed PSI and PSG based on surgeons' defined surgical planning in MIMICS (version 16, Materialise, Belgium). After neoadjuvant chemotherapy, surgeries were assisted with 12 NAVI (Stryker), 4 PSG, or a combination (4 NAVIG) (Figure 1).Oncological results and limb functions were recorded. Patient overall disease survival and PSI survival with revision surgery as endpoint were calculated using Kaplan-Meier method (R Core Team (2023).ResultsWith a mean follow-up of 9.9 years (4.7 -17.7), three patients died from disease progression, and one patient defaulted follow-up. Using Kaplan-Meier, patient survival was 90% and 81.8% at five and ten years (Figure 2A). PSI survival was 94.1% and 86.9% at five and ten years (Figure 2B). One Henderson Type II aseptic loosening and two Type III structural failures required major implant components to be revised. MSTS score was 29.2 out of 30 (28-30). Surgical margins were all negative in bone except one soft tissue positive margin. All PSIs matched well to the retained articular bones intraoperatively and showed osseointegration at PSI junctions (except one) and continuous joint growth postoperatively.DiscussionWith 3D planning and tools like NAVI and PSG, technically demanding joint-preserving surgeries could be accurately implemented as planned with excellent limb and joint function without compromising oncological results[4]. The computer-assisted approach might minimize soft tissue detachment by retaining the blood supply to the small articular bone segments. Osseointegration at the well-matched PSI junction suggested stable primary fixation and secondary healing of the PSI [5]. More cases and comparisons with conventional joint-sacrificing surgery were needed.
Fluoroscopy-based Robotic-assisted Total Hip Arthroplasty Resulted in Greater Improvements in Hip-specific Outcome Measures at One-year Compared to CT-based Robotic-assisted Technique
Authors: Ong Christian , Buchan Graham , Hecht II Christian , Liu David , Petterwood Joshua , Kamath Atul 
Published: December 2024

Introduction: Most of the literature on robotic-assisted total hip arthroplasty (THA) outcomes is derived from a single computerized tomography-based robotic (CT-RTHA) platform. The purpose of this study was to compare one-year patient reported outcome measures (PROMs) between a novel, fluoroscopy-based, robotic-assisted (FL-RTHA) system and a CT-RTHA system.Materials and methods: A review of 85 consecutive FL-RTHA and 125 consecutive CT-RTHA was conducted. All cases were performed via a direct anterior approach by one of two surgeons, during the same time period, for a pre-operative diagnosis of osteoarthritis, avascular necrosis, or rheumatoid arthritis. Outcomes included one-year post-operative Veterans RAND-12 (VR-12) Physical (PCS)/Mental (MCS), Hip Disability and Osteoarthritis Outcome (HOOS) Pain/Physical Function (PS)/Joint Replacement (JR), and University of California Los Angeles (UCLA) Activity scores. The primary comparative endpoint was the magnitude of improvements between pre- and post-operative scores.Results: Patients in the FL-RTHA cohort had lower pre-operative VR-12 PCS, HOOS Pain, HOOS-PS, HOOS-JR, and UCLA Activity scores compared to patients in the CT-RTHA cohort. Patients in the FL-RTHA cohort reported significantly greater improvements in HOOS-PS scores (-41.54 vs. -36.55; p=0.028) than patients in the CT-RTHA cohort. Both cohorts experienced similar rates of post-operative complications requiring reoperation/revision surgery (FL-RTHA 0% vs. CT-RTHA 3.20%; p=0.095).Conclusions: Both robotic techniques produced similar excellent PROM scores at one-year post-operative. However, use of the novel, fluoroscopy-based robotic system resulted in greater improvements in HOOS-PS at one-year relative to the computerized tomography-based robotic technique.
Population dynamics of grey mackerel fish (Thunnus tonggol) caught in fishery management areas (WPP 711)
Authors: Hadinata Fitra Wira , Ahmad Mulyadi , Utami Pratita Budi 
Published: December 2024

Grey mackerel is a fish that originates from tropical and subtropical waters worldwide. This pelagic fish has very important economic value in the Indonesian fishing industry. Grey mackerel production in WPP 711 using gillnet fishing gear has shown a fluctuating trend in recent years. This research is to estimate the stock of grey mackerel fish caught by fishermen who landed at PPN Pemangkat and Sungai Rengas Fishing Port. This research uses two data collection methods, namely primary and secondary data collection. The results of data analysis of the relationship between length and weight in the catch of grey tuna fish of 1,015 total fish samples produced the equation W = 0.0929x2.5504 (r2 = 0.8764) with a value of 0.0929 and the b value of 2,5504. Based on the results of the t-test, it shows that the value of b 3 in the growth pattern is negative allometric, meaning that the relationship between length and weight has a slow and rapid increase in weight compared to the increase in length. The landed grey mackerel had a growth rate coefficient (K) = 0.40. Tuna fish obtained a total mortality value (Z) of 1.81/ year. The exploitation rate (E) of grey tuna caught is 0.28/ year, which means the exploitation rate is still relatively low.Keywords: Gray mackerel; Pelagic Fish; Population dynamics; WPP 711Grey mackerel is a fish that originates from tropical and subtropical waters worldwide. This pelagic fish has very important economic value in the Indonesian fishing industry. Grey mackerel production in WPP 711 using gillnet fishing gear has shown a fluctuating trend in recent years. This research is to estimate the stock of grey mackerel fish caught by fishermen who landed at PPN Pemangkat and Sungai Rengas Fishing Port. This research uses two data collection methods, namely primary and secondary data collection. The results of data analysis of the relationship between length and weight in the catch of grey tuna fish of 1,015 total fish samples produced the equation W = 0.0929x2.5504 (r2 = 0.8764) with a value of 0.0929 and the b value of 2,5504. Based on the results of the t-test, it shows that the value of b 3 in the growth pattern is negative allometric, meaning that the relationship between length and weight has a slow and rapid increase in weight compared to the increase in length. The landed grey mackerel had a growth rate coefficient (K) = 0.40. Tuna fish obtained a total mortality value (Z) of 1.81/ year. The exploitation rate (E) of grey tuna caught is 0.28/ year, which means the exploitation rate is still relatively low. Keywords: Gray mackerel; Pelagic Fish; Population dynamics; WPP 711
Using Educational Robotics in Chemistry Education: A Systematic Review
Authors: Lotriet Hugo , Gouws Patricia 
Published: December 2024

Although the value of educational robotics (ER) is recognised in science, technology, engineering, and mathematics (STEM) disciplines, limited research has been published that focusses on using ER to support and enhance chemistry education (CE). This article considers the existing body of scholarly knowledge related to the use of ER in CE published in scholarly literature by means of a systematic literature review. To structure the findings conceptually, a Robotics-Education-Chemistry Considerations (RECC) framework was developed and applied. The findings indicate that the use of ER in CE is understudied. ER is largely applied to enhance the operational and content aspects of traditional CE, rather than to exploit the affordances related to modern education theories and practices that using ER potentially offers to CE.
Eccentric Resistance Exercise Effects on Older Adults With Metabolic Syndrome
Authors: Rohadhia Wafina , Kudiarasu Christine , Koeda Tomoko , Katsura Yoshihiro , Nosaka Kazunori , Singh Favil 
Published: December 2024

Background
This nonrandomized pilot study explored how whole-body eccentric resistance exercise training (ECC-RT) would change physical fitness and health parameters of older adults with metabolic syndrome symptoms. We hypothesized that ECC-RT would effectively improve neuromuscular and cardio-metabolic parameters.

Methods
Six men and 11 women aged between 62 and 79 (70.0 ± 5.0) years with body mass index &gt;25 kg · m−2, dyslipidemia, and some indications of metabolic syndrome participated in this study. All performed 8 ECC-RT exercises of the major muscle groups twice a week for 8 weeks with a gradual increase in intensity from 10% to 100% of their maximal concentric strength assessed by 1-repetition maximum (1-RM) for each exercise. Before and after the training intervention, 1-RM strength of all exercises, physical function tests, sensory organization test (SOT) for balance, body composition, and some cardio-metabolic blood markers were measured.

Results
All participants completed 16 training sessions without any injuries or adverse effects. The concentric 1-RM strength increased (P &lt; 0.05) for all exercises from baseline by 34.1% ± 13.8% (lateral pulldown) to 115.8% ± 108.7% (calf raise). Significant (P &lt; 0.05) improvement of 400-m walk (12.8% ± 6.7%), repeated chair rise (18.6% ± 16.4%), timed up and go (13.6% ± 6.0%), and vestibular (26.1% ± 37.9%) and total score (6.5% ± 8.3%) in SOT were evident, although large variations in responses were observed among participants. However, no significant changes in body composition and blood markers were found.

Conclusion
The ECC-RT was tolerable for all participants and was effective for improving muscle strength and some physical function tests, but did not affect the metabolic syndrome parameters, possibly because of the short intervention period and small sample size.
A Rare Case Report on Jaundice, Alcoholic Liver Disease with a History of Herbal Medicine Induced Liver Injury
Authors: G Varsha 
Published: December 2024

Background: Alcoholic liver disease (ALD) is a complex condition caused by excessive alcohol consumption, affecting fatty liver, alcoholic hepatitis, and cirrhosis. Risk factors include alcohol intake, genetic predisposition, and co-existing liver conditions. Alcoholic fatty liver disease (AFLD) accumulates excessive fat in the liver, leading to steatosis and fibrosis. ALD complications include portal hypertension, liver failure, and hepatocellular carcinoma. The use of herbal medicines, such as tamarind and neem extracts, is also concerning due to potential liver damage. Increased awareness and caution are needed from patients and healthcare providers.
Case report: A 33-year-old male patient presented with symptoms including right hypochondrium pain, yellowish discoloration of the sclera, fever, decreased urine output, light yellow tongue, and generalized weakness. He was a chronic alcoholic, consuming various alcoholic beverages for 15 years. His dietary routine was mixed, but he preferred non-vegetarian foods. His family suggested he consume traditional herbal medicine to treat jaundice. After collecting his history, lab tests were conducted to confirm his diagnosis of alcoholic liver disease (ALD) with herbal medicine-induced liver (DILI). LFT tests were alarming, and he was diagnosed with alcoholic liver disease with jaundice and DILI due to herbal medicine. To improve his symptoms and prevent liver failure complications, he was prescribed a list of medications to improve his symptoms and to prevent complications of liver failure.
Discussion: A holistic treatment approach is needed for patients with alcoholic liver disease and herbal medicine-induced liver injury, focusing on symptom relief, liver function enhancement, and complication prevention. This includes lifestyle changes, nutritional support, and managing potential issues. Regular monitoring is crucial for adjustments.
Conclusion: This case report highlights the complex relationship between alcoholic liver disease and herbal medicine-induced liver injury, especially in jaundice cases. It emphasizes the need for thorough patient histories, increased awareness of hepatotoxic potential, and educating patients about alcohol and herbal supplement risks. It calls for multidisciplinary collaboration, enhanced regulation, and safety evaluations of herbal medicines to protect public health. It also underscores the importance of continuous monitoring and monitoring patients with liver injury histories.

Keywords: ALD, Herbal medicine, DILI, Liver failure, Patient care
Anger as defiance, anger as self in Anna Langfus’ Le Sel et le soufre and Les Bagages de sable
Authors: Grenaudier-Klijn France 
Published: December 2024

For Polish-born writing-in-French novelist Anna Langfus (1920-1966), fiction writing ought to aim both at self-expression and other-communication. Chiefly concerned with the question of post-Shoah identity and refusing to reduce characters to the oversimplified position of victims, her narratives foreground the voice and experience of the survivor, while seeking ethical communication with readers. Hence, Langfus appeals to the common human-being-ness of characters and readers, through the evocation of universal emotions and feelings. Anger is one such emotion, and this contribution proposes to analyse the narrative and ethical role of anger in her first two novels: Le Sel et le soufre (1960) and Les Bagages de sable (1962).
The article will first provide a quick overview of the conceptualisation and interpretation of anger in religious, philosophical, and psychological contexts. It will then include a reminder of the difficulties Shoah survivors met to be heard in the immediate post-war years in France and situate Langfus within her historical context.
The second part of the discussion will examine episodes of anger in Langfus’ first two novels and propose an interpretation of anger as a tool harnessed by the protagonists to remain in contact with their lost loved ones and with their own intimate selves.
The discussion will conclude on the ‘communicability’ inherent to Langfus depiction of anger, suggesting that the inscription of this ambivalent emotion allows the novelist to challenge stereotypical representation of post-Shoah survivors, while also, and perhaps more importantly, enabling her to call to an (ideal) reader, now drawn into a communal space of human frailty.
NILAI FILOSOFIS KACAR KUCUR DALAM PERKAWINAN ADAT JAWA PERSPEKTIF AL-‘ADAH AL-MUHAKKAMAH DI DESA KERAS KABUPATEN JOMBANG
Authors: Alkhusni Muhammad Fatih , Kusumawati Ita Rahmania , Mu’allim Much. 
Published: December 2024

Pelaksanaan adat kacar kucur dalam konteks pernikahan Jawa, yang merupakan tradisi turun-temurun dengan makna mendalam. Adat ini melibatkan pengantin pria yang menuangkan biji-bijian, rempah-rempah, dan uang logam ke pangkuan pengantin wanita, melambangkan tanggung jawab suami dan simbolisasi kasih sayang. Nilai filosofis yang terkandung dalam prosesi ini mencakup pengayoman, ketenangan, dan penghormatan antara suami dan istri, serta peran penting orang tua dalam membimbing pasangan pengantin. Dalam perspektif al-‘adah al-muhakkamah, kacar kucur dianggap tidak bertentangan dengan hukum Islam, sehingga eksistensinya tetap terjaga dalam masyarakat modern. Penelitian ini menekankan bahwa adat kacar kucur bukan hanya sekadar tradisi, tetapi juga mencerminkan nilai-nilai spiritual yaitu yang terdapat dalam al-qur’an surat an-nisa’ ayat 34, bahwa “Pria (suami) adalah pemangku pada tiap-tiap Wanita (istri) dikarenakan Allah sudah memperbesar mayoritas mereka (pria) pada mayoritas yang lain (wanita) dan sebab itu mereka (pria) sudah menafkahkan bebrapa dari kekayaannya.
Kata Kunci: filosofi, kacar kucur, adat jawa, al-‘adah al-muhakkamah

ABSTRACT
Implementing the Kacar Kucur custom in the context of Javanese weddings, which is a tradition passed down from generation to generation with deep meaning. This custom involves the groom pouring grains, spices, and coins into the bride's lap, symbolizing the husband's responsibilities and symbolizing affection. The philosophical values ​​contained in the process include protection, calm and respect between husband and wife, as well as the important role of parents in guiding the bridal couple. In the perspective of al-'adah al-muhakkamah, kacar kucur is considered not to conflict with Islamic law, so its existence is maintained in modern society. This research emphasizes that the Kacar Kucur custom is not just a tradition, but also reflects spiritual values, namely those contained in the Al-Qur'an, Surah An-Nisa' verse 34, that "Men (husbands) are the guardians of every woman ( wives) because Allah has enlarged their majority (men) over the majority of others (women) and because of that they (men) have spent some of their wealth.

Keywords : philosophy, kacar kucur, Javanese customs, al-'adah al-muhakkamah
A FENOMENOLOGIA DE HUSSERL
Authors: Portes Luan Marcos 
Published: December 2024

Resumo: A presente pesquisa expressa o método fenomenológico proposto por Edmund Husserl (1859-1938). Entende-se o método fenomenológico desenvolvido por Husserl, como exegese da capacidade do homem conhecer e fazer ciência do mundo percebido. Por meio da redução Fenomenologia e eidética, cogitou-se vislumbrar e apontar as raízes da autêntica condição do homem perante a realidade que lhe é verdadeiramente revelação, e o dado da experiência reflexiva da consciência como expressão última da realidade íntima do homem, na correlação entre a atitude da consciência e os dados que a ela se anunciam como essências reais. A ciência, a partir da abordagem feita por Husserl, mostrou ter como solo último a pura experiência do ser consciente que se coloca diante do mundo que se lhe oferece como realidade em si, por meio do desvelamento que o Eu consciente faz do ser do mundo.
Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method
Authors: Wang Ning 
Published: December 2024

IntroductionNeodymium, a rare earth element, has been shown to induce genotoxicity in mice, but the molecular mechanisms behind this effect are not fully understood. This study aims to investigate the genotoxic effects of intragastric administration of neodymium nitrate (Nd(NO3)3) over 28 consecutive days and to elucidate the underlying molecular mechanisms.MethodsWe detected the content of neodymium in mouse liver tissue using ICP-MS and assessed the percentage of tail DNA in mouse hepatocytes using the alkaline comet assay to evaluate genotoxicity. Additionally, we evaluated genetic toxicological biomarkers (reactive oxygen species (ROS), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and γ-H2AX) and the expression levels of genes related to the p53 pathway in the mouse liver.ResultsOur findings indicate a potential accumulation of (Nd(NO3)3) in the livers of mice, leading to DNA double-strand breaks in hepatocytes, as evidenced by comet and γ-H2AX assays. Nd(NO3)3 significantly increased the percentage of tail DNA in hepatocytes and upregulated the expression of molecules related to the p53 pathway, including ATM, Wip1, ATR, Chk2, MDM2, p53, p21, and NF-κB, at the transcriptional level. The treatment also effectively triggered the production of ROS, 8-OHdG, and γ-H2AX in liver tissue.DiscussionThese results suggest that (Nd(NO3)3) induces hepatic genotoxicity and injury in mice and modulates the expression of genes associated with DNA damage response, carcinogenesis, and inflammatory processes. The study provides insights into the molecular mechanisms by which neodymium nitrate exerts its genotoxic effects and underscores the importance of further investigating the potential health risks associated with neodymium exposure.
A eficácia da utilização do índice bispectral (BIS) na prática anestésica
Authors: Carvalho Pedro Henrique dos Santos , Ferreira Thamires Torres , Carvalho Marco Aurélio dos Santos 
Published: December 2024

O índice bispectral (BIS) é uma ferramenta desenvolvida para avaliar a profundidade da anestesia e o nível de sedação.O BIS, através do eletroencefalograma, utiliza-se de uma escala numérica que vai de 0 a 100, valores baixos indicam sedação e valores altos, estado de consciência. Com a introdução do BIS tornou-se possível mensurar de forma objetiva o grau de anestesia e consciência do paciente, frente a técnica tradicional de monitorização clínica.
Perfil das internações por Tuberculose do aparelho geniturinário no Brasil: análise de 2019 a 2023
Authors: Vicente Andressa Gonçalves , Flandoli Amanda Letícia Schell , Hortolam Isabela Monteiro , Girotto Suyanne Paula Schwade , Sandri João Carlos 
Published: December 2024

A tuberculose geniturinária frequentemente se origina por meio de uma disseminação hematogênica da bactéria Mycobacterium tuberculosis para os rins e órgãos genitais. Essa forma pode comprometer gravemente os rins e epidídimos, levando a complicações sérias, como insuficiência renal crônica e infertilidade.
Построение когнитивных карт на основе PESTLE-анализа и нечетких лингвистических оценок
Authors: Береза Н.В. , Береза А.Н. , Береза Д.А. 
Published: December 2024

В данной статье приводится алгоритм построения когнитивных карт на основе PESTLE-анализа и нечетких лингвистических оценок. Подробно рассматривается процесс построения когнитивной карты в табличной форме, который включает в себя определение целевого концепта и факторов влияния, построение слабо-связной нечеткой матрицы смежности, преобразование ее в нечеткую транзитивно-замкнутую матрицу (нечеткие лингвистические оценки преобразуются в числовые на основе нормированной нечеткой шкалы), получение матрицы парных взаимовлияний для сильно-связной когнитивной карты, а затем матрицы консонанса.
This article provides an algorithm for constructing cognitive maps based on PESTLE analysis and fuzzy linguistic assessments. The process of constructing a cognitive map in tabular form is considered in detail, which includes the definition of the target concept and factors of influence, the construction of a weakly connected fuzzy adjacency matrix, its transformation into a fuzzy transitively closed matrix (fuzzy linguistic estimates are converted into numerical ones based on normalized fuzzy scales) , obtaining a matrix of pairwise mutual influences for a strongly connected cognitive map, and then a matrix of consonance.