bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing the Catalogue of the World’s Natural History Collections
Authors: Hobern Donald , Paul Deborah L , Robertson Tim , Groom Quentin , Thiers Barbara , Asase Alex , Luo Maofang , Semal Patrick , Woodburn Matt , Zschuschen Eliza 
Published: October 2020

Information about natural history collections helps to map the complex landscape of research resources and assists researchers in locating and contacting the holders of specimens. Collection records contribute to the development of a fully interlinked biodiversity knowledge graph (Page 2016), showcasing the existence and importance of museums and herbaria and supplying context to available data on specimens. These records also potentially open new avenues for fresh use of these collections and for accelerating their full availability online.
A number of international (e.g., Index Herbariorum, GRSciColl) regional (e.g. DiSSCo and CETAF) national (e.g., ALA and the Living Atlases, iDigBio US Collections Catalog) and institutional networks (e.g., The Field Museum) separately document subsets of the world's collections, and the Biodiversity Information Standards (TDWG) Collection Descriptions Interest Group is actively developing standards to support information sharing on collections. However, these efforts do not yet combine to deliver a comprehensive and connected view of all collections globally.
The Global Biodiversity Information Facility (GBIF) received funding as part of the European Commission-funded SYNTHESYS+ 7 project to explore development of a roadmap towards delivering such a view, in part as a contribution towards the establishment of DiSSCo services within a global ecosystem of collection catalogues. Between 17 and 29 April 2020, a coordination team comprising international representatives from multiple networks ran Advancing the Catalogue of the World’s Natural History Collections, a fully online consultation using the GBIF Discourse forum platform to guide discussion around 26 consultation topics identified in an initial Ideas Paper (Hobern et al. 2020). Discussions included support for contributions in Spanish, Chinese and French and were summarised daily throughout the consultation.
The consultation confirmed broad agreement around the needs and goals for a comprehensive catalogue of the world’s natural history collections, along with possible strategies to overcome the challenges. This presentation will summarise the results and recommendations.
Le paradoxe de la conscience chez Pierre Bayle
Authors: Abel Olivier 
Published: October 2020

La liberté de conscience chez Pierre Bayle oscille. D’un côté, nous avons l’idée minimale que « les droits de la conscience sont directement ceux de Dieu lui-même », que le dictamen de la conscience ne nous appartient pas plus que la couleur de nos yeux. La conscience est ici protégée de toute intervention par un voile d’ignorance et d’impuissance, issu d’une lecture hétérodoxe de la prédestination. De l’autre, nous avons l’idée que tout est ouvert à la discussion, dans une utopie marine de société indocile et de libre tolérance, sans lois ni État. La République des Lettres « est un état extrêmement libre. On n’y reconnaît que l’empire de la vérité et de la raison, et sous leurs auspices on fait la guerre innocemment à qui que ce soit ». Comment penser ensemble ces deux aspects ? Olivier Abel montre que les paradoxes de Bayle reposent sur son incessante manière de montrer la cohérence plausible de divers points de vue, qui sont autant d’ essais de soi dans un processus de subjectivation plurielle.
Les deux versants de l’hallucination clinique
Authors: Kapsambelis Vassilis 
Published: October 2020

La psychopathologie du XIX e siècle découvre les parentés entre rêve et hallucinations, ces dernières devenant le produit d’une régression. Freud développe ce modèle, tout en suggérant un second, lié au contraire à l’absence de régression et à l’investissement de la représentation de mot au détriment de la représentation de chose, suite aux processus de « perte de la réalité ». Ces deux mécanismes sont articulés avec les notions d’hallucination primitive et de trace mnésique, et décrivent deux destins différents de l’accueil de la perception dans le fonctionnement mental, la perception étant la voie d’accueil de l’objet dans son altérité. Les deux mécanismes semblent correspondre à deux types d’hallucinations cliniques dans l’œuvre de Freud, les unes en rapport avec l’hystérie, les autres en rapport avec la schizophrénie.
Addition of docetaxel or abiraterone to androgen deprivation therapy in metastatic hormone-sensitive prostate cancer in Indian population
Authors: Gupta Alok , Hussain Shaik Maheboob , Sonthwal Neha , Chaturvedi Harit 
Published: October 2020

Background:
The addition of docetaxel or abiraterone to androgen deprivation therapy (ADT) achieves superior survival outcomes in metastatic hormone-sensitive prostate cancer (mHSPC) in predominantly Western population. We sought to evaluate the treatment outcomes of adding docetaxel or abiraterone to ADT in Indian population.

Methods:
We reviewed the medical records of ninety patients with newly diagnosed mHSPC who received treatment between January 2015 and June 2018. Patients received ADT alone or ADT + docetaxel or ADT + abiraterone as initial treatment. Monthly clinical evaluation and prostate-specific antigen (PSA) measurement were done. Outcome measures analyzed included PSA decline <90%, serological complete response (sCR) (PSA < 0.2 ng/ml), and progression to CRPC. Outcome variable was compared using Fisher's exact test.

Results:
Patients received ADT alone (n = 37) or ADT + docetaxel (n = 31) or ADT + abiraterone (n = 22). The median age was 67.5 years (range, 41–87 years) and the median PSA was 88.5 ng/ml (range, 1.12–4000). PSA decline <90% was seen in 22 (73%), 24 (86%), and 17 (94%) patients in the ADT alone, ADT + docetaxel, and ADT + abiraterone groups. sCR was achieved in 5 (17%), 10 (36%), and 9 (50%) patients in the ADT alone, ADT + docetaxel, and ADT + abiraterone groups. Progression to CRPC was observed in 18 (60%), 11 (39%), and 2 (11%) patients in the ADT alone, ADT + docetaxel, and ADT + abiraterone groups.

Conclusion:
The addition of docetaxel or abiraterone to ADT achieves a deeper serological response and reduces progression to CRPC compared to ADT alone in mHSPC patients of Indian origin. Longer follow-up is required to comment on overall survival and also to determine which combination (ADT + docetaxel or ADT + abiraterone) is superior to others, if at all.
Antitumor activity of Albizia lebbeck L. against Ehrlich ascites carcinoma in vivo and HeLa and A549 cell lines in vitro
Authors: Kavitha Chilaka Naga , Raja K. Dilip , Rao S. Krishna 
Published: October 2020

Aim of the Study:
The aim of the present study was to explore the antitumor activity of the ethanolic extract of Albizia lebbeck L. pods against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and its cytotoxic effect against HeLa and A549 cell lines in vitro.

Materials and Methods:
Antitumor activity of ethanolic extract of A. lebbeck L. (ALEE) pods was evaluated in Swiss albino mice against EAC cell lines at the doses of 200 and 400 mg/kg body weight which were given by intraperitoneal route of administration and was compared with 5-fluorouracil (5-FU), the reference standard. The extract and 5-FU were administered for 14 consecutive days. After 24 h of the last dose and 18 h of fasting, the mice were sacrificed and the antitumor effect of ALEE was assessed by evaluating tumor volume, viable and nonviable tumor cell count, increase in life span, and hematological parameters of EAC-bearing hosts.In vitro cytotoxicity has been assessed using (2,3-bis[2-Methoxy-4-nitro-5sulfophenyl]-2H-tetrazolium-5-carboxyanilide inner salt assay method and was compared with cisplatin, the reference standard.

Results:
ALEE showed direct cytotoxicity on EAC cells in a dose-dependent manner. ALEE exhibited a significant (P < 0.001) decrease in the body weight, tumor volume, viable cell count, tumor weight, and elevated the life span of EAC tumor-bearing mice. Hematological profile such as red blood cell, hemoglobin, white blood cell, and platelet count was reverted to the normal level in ALEE-treated mice.

Conclusion:
The results showed that the ethanolic extract of A. lebbeck L. has a powerful antitumor activity because it was effective in significantly inhibiting the tumor growth in both in vivo and in vitro cancer cell lines.
Anticancer, antioxidant, and hepatoprotective activity of Saussurea lappa, C.B. clarke (qust) on human hepatoma cell line
Authors: Ansari Shabnam , Hasan Kazim , Bhat Sajad 
Published: October 2020

Background:
Liver cancer is considered as one of the most widespread malignancies across the globe. According to a recent estimate, about 782,000 people were diagnosed with liver cancer, out of which 746,000 people died. Conventional anticancer therapy cannot fulfill all the clinical needs due to accessibility, clinical efficacy, and safety issues. Hence, the need of novel inexpensive drugs from traditional medicine as potential chemotherapeutic agent becomes utmost urgent. Root of Saussurea lappa, C.B. Clarke (Unani name, qust) has been used in the Unani medicine for the treatment of chronic liver diseases (warm-e-jigar sulb) including hepatocellular carcinoma since centuries.

Objective:
The objective is to study the anti-cancerous, antioxidant, and hepatoprotective activity of different extracts of SLE in vitro.

Materials and Methods:
MTT assay was used to determine the anticancer activity and EC50 of SLEs. Cell viability and cell inhibition were calculated. Apoptosis was studied by DAPI 4',6-diamidino-2-phenylindole (DAPI) staining. The in vitro hepatotoxicity of CCl4 was produced and hepatoprotective properties of different concentrations of ethanolic (ESL), aqueous (ASL), and hydroethanolic extract of Saussurea lappa (HSL) have been evaluated by measuring cell viability in HepG2 cells.

Results:
MTT assay revealed that the molecule reduced the cell viability of HepG2 cancer cells. Test drugs induced apoptosis in a concentration-dependent manner, as indicated by DAPI staining. In addition, ESL, ASL, and HSL also reduced the colony-forming potential of the HepG2 cell. ESL, ASL, and HSL were observed to protect the HepG2 cells from CCl4 induced injury in a dose-dependent manner.

Conclusion:
The observed effect substantiated the anti-cancerous, antioxidant, and hepatoprotective activity of SLEs in HepG2 Cells.
Redesigning the Clinical Learning Environment to Improve Interprofessional Care and Education: Multi-Method Program Evaluation of the iPACE Pilot Unit
Authors: Hallen Sarah , Van der Kloot Thomas , McCormack Christyna , Han Paul K. J. , Lucas Frances L. , Wierda Lisbeth , Meyer Daniel , Varaklis Kalli , Bing-You Robert 
Published: October 2020

ABSTRACT

Background
In 2016, Maine Medical Center received an Accreditation Council for Graduate Medical Education Pursuing Excellence in Innovation grant to redesign the clinical learning environment to promote interprofessional care and education. The Interprofessional Partnership to Advance Care and Education (iPACE) model was developed and piloted on an adult inpatient medicine unit as an attempt achieve these aims.

Objective
We describe the iPACE model and associated outcomes.

Methods
Surveys and focus groups were employed as part of a multimethod pragmatic observational strategy. Team surveys included relational coordination (RC): a validated proprietary measure of interpersonal communication and relationships within teams. Pre-iPACE respondents were a representative historical sample from comparable inpatient medical units surveyed from March to April 2017. iPACE respondents were model participants surveyed March to August 2018 to allow for adequate sample size.

Results
Surveys were administered to pre-iPACE (N = 113, response rate 74%) and iPACE (N = 32, 54%) teams. Summary RC scores were significantly higher for iPACE respondents (iPACE 4.26 [SD 0.37] vs 3.72 [SD 0.44], P &lt; .0001), and these respondents were also more likely to report a professionally rewarding experience (iPACE 4.4 [SD 0.6] vs 3.5 [SD 1.0], P &lt; .0001). Learners felt the model was successful in teaching interprofessional best practices but were concerned it may hinder physician role development. Patient experience was positive.

Conclusions
This pilot may have a positive effect on team functioning and team member professional experience and patient experience. Learner acceptance may be improved by increasing autonomy and preserving traditional learning venues.
An evaluation of six-year Stenotrophomonas maltophilia infections in a university hospital
Authors: Ince Nevin , Yekenkurul Dilek , Danış Ayşe , Çalışkan Emel , Akkaş İdris 
Published: October 2020

Background: Stenotrophomonas maltophilia is a Gram-negative bacillus and opportunistic emergent pathogen causing hospi- tal-acquired infections (HAIs). Due to risk factors such as prolonged intensive care unit stay and invasive procedures, it has become one of the leading causes of HAIs.
Objective: The aim of this study was to evaluate the epidemiology of S.maltophilia infections over a six-year period at Düzce University Hospital, Turkey.
Methods: The incidence, clinical characteristics, antimicrobial susceptibility and outcomes of nosocomial S. maltophilia in- fections during this period were retrospectively analyzed.
Results: During the study period, 67 samples obtained from 61 patients were identified. Pneumonias (82%) were the most common HAIs, followed by bloodstream infections (10.5%), urinary tract infections (3%), skin and soft tissue infections (3%) and surgical site infection (1.5%). Admission to intensive care, hospitalization exceeding 30 days, and previous use of broad-spectrum antibiotics constituted risk factors. Resistance to cotrimoxazole (6%) was lower than that to levofloxacin (18%).
Conclusion: The most important risk factors for S.maltophilia infection in patients are previous exposure to antibiotics, pro- longed hospitalization and invasive procedures such as mechanic ventilation. Discharging patients as early as possible with the rational use of antibiotics may be effective in reducing S. maltophilia infections and resistance rates.
Keywords: Stenotrophomonas maltophilia; hospital-acquired infections; epidemiology; risk factors.
Hemorrhagic fever in Saudi Arabia: challenge to public health, effective management and future considerations
Authors: A Kumosani Taha , L Al-Malki Abdulrahman , S Razvi Syed , J Balgoon Maha , Kaleem Mohammed , A Huwait Etimad , A Alghamdi Maryam , S Yaghmoor Soonham , O Abualnaja Khalid , K Barbour Elie , A AL-Madani Khalid , H AlToukhi Majdi , T Kumosani Afnan , S Moselhy Said 
Published: October 2020

Background: Viral hemorrhagic fevers (VHF) refers to a group of febrile illnesses caused by different viruses that result in high mortality in animals and humans. Many risk factors like increased human-animal interactions, climate change, increased mobility of people and limited diagnostic facility have contributed to the rapid spread of VHF.
Materials: The history of VHFs in the Saudi Arabian Peninsula has been documented since the 19th century, in which many outbreaks have been reported from the southwestern region of Saudi Arabia. Despite presence of regional network of experts and technical organizations, which expedite support and respond during outbreaks, there are some more challenges that need to be addressed immediately. Gaps in funding, exhaustive and inclusive response plans and improved surveillance systems are some areas of concern in the region which can be dealt productively. This review primarily focusses on the hem- orrhagic fevers that are caused by three most common viruses namely, the Alkhurma hemorrhagic fever virus, Rift valley fever virus, and Dengue fever virus.
Conclusion: In summary, effective vector control, health education, possible use of vaccine and concerted synchronized efforts between different government organizations and private research institutions will help in planning effective out- break-prevention and response strategies in future.
Keywords: Viral fever; hemorrhagic fever (VHF); Saudi Arabia; challenges; management; future considerations.
Rodents as potential hosts and reservoirs of parasites along the edge of a Central African forest: Bwindi impenetrable national park, South Western Uganda
Authors: Mawanda Patrick , Rwego Innocent , J Kisakye John , Sheil Douglas 
Published: October 2020

Background: Rodents which constitute 42% of the world’s mammalian population are major reservoirs of pathogens that cause zoonoses. Currently we know little about rodents’ potential zoonotic transfer from human settlements into protected areas and how any such threats might be reduced.
Objective: To investigate the role of rodents as reservoirs of zoonotic pathogens along the boundary of Bwindi.
Methods: A rodent inventory in three villages along the edge of Bwindi, was carried using live trapping techniques and the local rodents’ ecto and endoparasite fauna investigated.
Results: Two hundred eighty eight rodents captured belonged to 24 species, 17 genera and 4 families with Lophuromys aquilus being most abundant (30.2%). 240 ectoparasites which included mites, fleas and ticks were collected from 88 rodents out of 249. Proamys jacksoni rodents were most infested. Although the mites represented the largest proportion (84.6%), the highest species diversity was shown among the fleas (9 species). Some 36.9% of the rodents were infected with endopara- sites of which L. aquilus haboured most. Endoparasitic genera identified included Nippostrongylus, Ascaris, Strongyloides, Trichuris, Hymenolepis, Taenia and Cryptosporidium.
Conclusion: Rodents have a zoonotic potentiality. There is need for developing effective integrated rodent management programs against rodent to reduce chances of parasite transmission within the protected areas.
Keywords: Bwind; human disease; mountain gorillas; rodents; transmission.
Socio-demographic predictors of gender inequality among heterosexual couples expecting a child in south-central Uganda
Authors: J Vrana-Diaz Caroline , E Korte Jeffrey , Gebregziabher Mulugeta , Richey Lauren , Selassie Anbesaw , Sweat Michael , Chemusto Harriet , Wanyenze Rhoda 
Published: October 2020

Background: Gender inequality is a pervasive problem in sub-Saharan Africa, and has negative effects on health and de- velopment.
Objective: Here, we sought to identify socioeconomic predictors of gender inequality (measured by low decision-making power and high acceptance of intimate partner violence) within heterosexual couples expecting a child in south-central Uganda.
Method: We used data from a two-arm cluster randomized controlled HIV self-testing intervention trial conducted in three antenatal clinics in south-central Uganda among 1,618 enrolled women and 1,198 male partners. Analysis included Cochran Mantel-Haenzel, proportional odds models, logistic regression, and generalized linear mixed model framework to account for site-level clustering.
Results: Overall, we found that 31.1% of men had high acceptance of IPV, and 15.9% of women had low decision-making power. We found religion, education, HIV status, age, and marital status to significantly predict gender equality. Specifically, we observed lower gender equality among Catholics, those with lower education, those who were married, HIV positive women, and older women.
Conclusion: By better understanding the prevalence and predictors of gender inequality, this knowledge will allow us to better target interventions (increasing education, reducing HIV prevalence in women, targeting interventions different reli- gions and married couples) to decrease inequalities and improve health care delivery to underserved populations in Uganda.
Keywords: Gender inequality; Pregnancy; HIV/AIDS; Prenatal Care; Uganda.
Effects of miR-489 targeting on SOX4 gene on proliferation and apoptosis of human hepatocellular carcinoma cells
Authors: Wang Bing , Jin Wang-Xun , Zhang Yun-Li , Huang Ling , Ni Hai-Bin , Fang Dilong 
Published: October 2020

Background: Hepatocellular carcinoma is one of the most common malignant tumors found all over the globe. Despite advances in surgery and chemotherapy, the five-year survival rate of patients with hepatocellular carcinoma is still low. It is known that the proliferation of hepatocellular carcinoma cells is closely related to the occurrence, development and prog- nosis of hepatocellular carcinoma. The present work investigates the expression of microRNA-489 (miR-489) in human hepatocellular carcinoma cells and its effect on the biological behavior of human hepatocellular carcinoma cells.
Methods: The expression of miR-489 by fluorescence quantitative PCR detection in 30 patients with hepatoblastoma of liver cancer tissues and adjacent tissues was studied. Also, the determination of hepatoblastoma in four cell lines with differ- ent metastatic potential (HR8348, HCT116, HT29 and HEPG2) and the expression of miR-489 during miR-489 simulation process was studied. MTT assay, flow cytometry and Western blot analysis were performed to know the cell proliferation to detect the changes in cell cycle, apoptosis of cells, and SOX4 gene expression respectively.
Results: RT-PCR results showed that the cells compared with pre-cancerous tissue, the expression level of miR-489 in hepatocellular carcinoma tissues than in adjacent tissue significantly decreased (P<0.05), and with liver cancer cell metastasis increased (P<0.05); analogue transfection constructed miR-489 overexpressing HEPG2 cell line by microRNA. MTT results showed that miR-489 can inhibit the proliferation of HEPG2 cells, the differences were statistically significant (P<0.05); flow cytometry results showed that miR-489 mimics was transfected into HEPG2 cells at 48 hours had no significant effect on cell cycle distribution (P > 0.05); but miR-489 expression could induce apoptosis, compared with the control group, the apoptosis of miR-489 mimics was significantly increased and the difference was statistically significant (P < 0.05).
Conclusion: In conclusion, miR-489 can significantly inhibit the occurrence and development of hepatocellular carcinoma cells. The mechanism may be down regulated by the expression of SOX4 and inhibit cell proliferation. Further this study showed that the tumor cells SOX4 gene as a regulatory factor target the genes of miR-489 in hepatocellular carcinoma.
Keywords: Hepatocellular carcinoma; mircroRNA-489; SOX4; apoptosis.