bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feminist Storytelling and the Problem of White Feminism
Authors: Griffin Amanda 
Published: October 2020

Abstract
This article considers the problem of white feminism and how it is narrated. Part One argues that common strategies for solving this problem focus on reforming white feminist subjectivity; although these strategies have not achieved their desired effects, they remain popular because they narratively satisfy demands of feminist storytelling. They thus become traps. Part Two turns to literary studies for a methodological reorientation for Christian theology: away from ethics as a redemptive project pursued at the site of white feminist subjectivity, and toward a critical project that understands white womanhood as a textual figure in need of ongoing interpretation.
Hyperfine group ratio: a recipe for deriving kinetic temperature from the ammonia inversion lines
Authors: Wang Shen , Ren Zhiyuan , Li Di , Kauffmann Jens , Zhang Qizhou , Shi Hui 
Published: October 2020

ABSTRACT
Although ammonia is a widely used interstellar thermometer, the estimation of its rotational and kinetic temperatures can be affected by the blended hyperfine components (HFCs). We have developed a new recipe, referred to as the hyperfine group ratio (HFGR), which utilizes only direct observables, namely the intensity ratios between the grouped HFCs. As tested on the model spectra, the empirical formulae in the HFGR can derive the rotational temperature (Trot) from the HFC group ratios in an unambiguous manner. We compared the HFGR with two other classical methods, intensity ratio and hyperfine fitting, based on both simulated spectra and real data. The HFGR has three major improvements. First, it does not require modelling the HFC or fitting the line profiles, so it is more robust against the effect of HFC blending. Second, the simulation-enabled empirical formulae are much faster than fitting the spectra over the parameter space, so both computer time and human time can be saved. Third, the statistical uncertainty of the temperature ΔTrot as a function of the signal-to-noise ratio (S/N) is a natural product of the HFGR recipe. The internal error of the HFGR is ΔTrot ≤ 0.5 K over a broad parameter space of rotational temperature (10–60 K), linewidth (0.3–4 km s−1) and optical depth (0–5). When there is spectral noise, the HFGR can also maintain a reasonable uncertainty level at ΔTrot ≤ 1.0 K when S/N &gt; 4.
Cosmological parameter estimation via iterative emulation of likelihoods
Authors: Pellejero-Ibañez Marcos , Angulo Raul E , Aricó Giovanni , Zennaro Matteo , Contreras Sergio , Stücker Jens 
Published: October 2020

ABSTRACT
The interpretation of cosmological observables requires the use of increasingly sophisticated theoretical models. Since these models are becoming computationally very expensive and display non-trivial uncertainties, the use of standard Bayesian algorithms for cosmological inferences, such as Markov chain Monte Carlo (MCMC), might become inadequate. Here, we propose a new approach to parameter estimation based on an iterative Gaussian emulation of the target likelihood function. This requires a minimal number of likelihood evaluations and naturally accommodates for stochasticity in theoretical models. We apply the algorithm to estimate 9 parameters from the monopole and quadrupole of a mock power spectrum in redshift space. We obtain accurate posterior distribution functions with approximately 100 times fewer likelihood evaluations than an affine invariant MCMC, roughly independently from the dimensionality of the problem. We anticipate that our parameter estimation algorithm will accelerate the adoption of more accurate theoretical models in data analysis, enabling more comprehensive exploitation of cosmological observables.
Unit Equations on Quaternions
Authors: Huang Yifeng 
Published: October 2020

Abstract
A classical result about unit equations says that if Γ1 and Γ2 are finitely generated subgroups of ${\mathbb C}^\times$, then the equation x + y = 1 has only finitely many solutions with x ∈ Γ1 and y ∈ Γ2. We study a non-commutative analogue of the result, where $\Gamma_1,\Gamma_2$ are finitely generated subsemigroups of the multiplicative group of a quaternion algebra. We prove an analogous conclusion when both semigroups are generated by algebraic quaternions with norms greater than 1 and one of the semigroups is commutative. As an application in dynamics, we prove that if f and g are endomorphisms of a curve C of genus 1 over an algebraically closed field k, and deg( f), deg(g)≥ 2, then f and g have a common iterate if and only if some forward orbit of f on C(k) has infinite intersection with an orbit of g.
Associations of self-reported obstructive sleep apnea with total and site-specific cancer risk in older women: a prospective study
Authors: Huang Tianyi , Lin Brian M , Stampfer Meir J , Schernhammer Eva S , Saxena Richa , Tworoger Shelley S , Redline Susan 
Published: October 2020

Abstract

Background and Objectives
Chronic intermittent hypoxia resulting from obstructive sleep apnea (OSA) may activate multiple carcinogenic pathways and lead to cancer development.

Methods
We prospectively examined the association between OSA and cancer risk among 65,330 women in the Nurses’ Health Study who were free of cancer in 2008 (mean age: 73.3 years). Incident cancer diagnoses were collected until 2016 and confirmed by pathology reports. Clinically diagnosed OSA was self-reported in 2008 and updated in 2012. We used time-dependent Cox regression to estimate hazard ratios (HR) for the associations of OSA with total and site-specific cancer risk.

Results
We documented 5,257 incident cancer diagnoses during follow-up. In the age-adjusted model, OSA was associated with a 15% (95% CI: 1.03, 1.29) increase in total cancer risk. The association became nonsignificant after adjustment for multiple cancer risk factors (HR: 1.08; 95% CI: 0.96, 1.21). When examining cancer risk by site, OSA was associated with significantly increased risk for lung (fully adjusted HR: 1.52; 95% CI: 1.07, 2.17), bladder (fully adjusted HR: 1.94; 95% CI: 1.12, 3.35), and thyroid cancer (fully adjusted HR: 2.06; 95% CI: 1.01, 4.22) and possibly increased risk for kidney cancer (fully adjusted HR: 1.59; 95% CI: 0.84, 3.01). When grouping cancer sites by risk factor profiles, OSA was positively associated with smoking-related cancers (fully adjusted HR: 1.37; 95% CI: 1.11, 1.67), and this association was stronger in never smokers than ever smokers.

Conclusion
While OSA was not independently associated with overall cancer risk in older women, significant associations were observed for smoking-related cancers, especially in nonsmokers.
Associations between sleep apnea and advanced brain aging in a large-scale population study
Authors: Weihs Antoine , Frenzel Stefan , Wittfeld Katharina , Obst Anne , Stubbe Beate , Habes Mohamad , Szentkirályi András , Berger Klaus , Fietze Ingo , Penzel Thomas , Hosten Norbert , Ewert Ralf , Völzke Henry , Zacharias Helena U , Grabe Hans J 
Published: October 2020

Abstract
Advanced brain aging is commonly regarded as a risk factor for neurodegenerative diseases, for example, Alzheimer’s dementia, and it was suggested that sleep disorders such as obstructive sleep apnea (OSA) are significantly contributing factors to these neurodegenerative processes. To determine the association between OSA and advanced brain aging, we investigated the specific effect of two indices quantifying OSA, namely the apnea–hypopnea index (AHI) and the oxygen desaturation index (ODI), on brain age, a score quantifying age-related brain patterns in 169 brain regions, using magnetic resonance imaging and overnight polysomnography data from 690 participants (48.8% women, mean age 52.5 ± 13.4 years) of the Study of Health in Pomerania. We additionally investigated the mediating effect of subclinical inflammation parameters on these associations via a causal mediation analysis. AHI and ODI were both positively associated with brain age (AHI std. effect [95% CI]: 0.07 [0.03; 0.12], p-value: 0.002; ODI std. effect [95% CI]: 0.09 [0.04; 0.13], p-value: &lt; 0.0003). The effects remained stable in the presence of various confounders such as diabetes and were partially mediated by the white blood cell count, indicating a subclinical inflammation process. Our results reveal an association between OSA and brain age, indicating subtle but widespread age-related changes in regional brain structures, in one of the largest general population studies to date, warranting further examination of OSA in the prevention of neurodegenerative diseases.
Quality Assurance Through Standard Operating Procedures Development and Deviation: A Medicolegal Death Investigation Systems Response to the COVID-19 Pandemic
Authors: Drake Stacy A. , Pierce Michal , Gumpeni Parmod , Giardino Eileen , Wolf Dwayne A. 
Published: October 2020

ABSTRACT
Standard operating procedures drive everyday practice within any organization, including those within a forensic setting. In the event of unusual circumstances, organizations must respond rapidly to address the impact on operations while ensuring that the quality and safety outcomes of routine services are not affected. This case study illustrates how standard operating procedures can be newly developed or modified, and rapidly deployed and quickly revised, to address unusual circumstances. The response to the COVID-19 pandemic is used as an example in this case report.
Integration and Standardization of Clinical Nurse Specialists in a Multihospital System
Authors: Katlen Jennifer , Crosby Lauren , Singleton Kathleen , Simon Julie , Di Fiore Tina , Kennedy Kathleen , Haight Kelly , Will Beverly 
Published: October 2020

Purposes/Objectives
In 2013, our multihospital system began the process to integrate and standardize clinical nurse specialist (CNS) practice. The goal was to standardize work and to increase collaboration as part of one system.

Description of the Project/Program
An overall job description was established to provide a framework inclusive of the broad areas of practice. Clinical nurse specialists were positioned to support medical-surgical, critical care, or women and children's services offered at community-based hospitals. Main campus and community-based CNSs led significant system integration efforts such as the standardization of nursing policies and procedures across the health system. System CNSs were created to address the needs of specialties common to all hospitals. As an example, a system CNS collaborated with the main campus and community-based CNSs to improve the delirium screening process.

Outcome
Clinical nurse specialists across the system have been integrated into a single team and report to 1 central director. Efforts to leverage expertise included the creation of a CNS-led practice council, increased communication via regular departmental meetings, and the sharing of resources using electronic platforms. There is now a CNS at hospitals that previously did not have one. The group values the structure and opportunities it provides as evidenced by favorable engagement surveys.

Conclusion
Our integration efforts improved collaboration and could be modified to benefit other care settings.
Birthweight by gestational age reference centile charts for Greek neonates
Authors: Tsagkari A , Pateras K , Ladopoulou D , Kornarou E , Vlachadis N 
Published: October 2020

ABSTRACTObjectiveThe development of population based, sex-specific, birthweight for gestational age (GA) first-time reference centile charts for liveborn singletons in Greece.DesignSecondary analysis of national birth registry dataParticipantsData of birthweight by GA of all 633201 singleton live births in Greece between 2011 and 2017 were collected from the Hellenic Statistical Authority (ELSTAT).Main outcome measuresAfter excluding implausible birthweights, we estimated gender specific birthweight centiles for every gestational week from 22nd to 40th+ using the Lambda-Mu-Sigma (LMS) method via the GAMLSS package in R. Small (10th centile) and large-for GA (90th centile) cut-offs in certain gestational weeks were compared to previously published charts.ResultsMore than 90% of the 621043 neonates were born at term (>37 weeks of GA). The mean birthweight for boys and girls at 40+ weeks of GA were 3473 grams and 3327 grams respectively. Most neonates were born at 38 weeks of GA with a mean birth-weight of 3097 (97655 girls) and 3237 (104722 boys) grams. The proposed national centiles identified more or less deviant percentages of small and large for GA neonates in comparison to other (inter)national centiles.ConclusionsThe new centile charts provide important information on the contemporary distribution of birthweight for gestational age in Greece. They may assist physicians to classify high-risk neonates at birth based on national population data. Accurate identification of those in need of special care will help to prevent possible adverse sequelae in the perinatal period and beyond.
CYP2C19*2, CYP2C19*17 and ITGB3 (PlA1/A2) polymorphisms and resulting therapeutic alterations of clopidogrel and aspirin: A clinical screening among CVD patients who undergone PCI
Authors: Nova Tasnova Tasnim , Jahan Ishrat , Momenuzzaman N.A.M. , Islam Rabbi Sikder Nahidul , Binder Thomas M.C. , Islam Mohammad Safiqul , Islam Md. Rabiul , Hasnat Abul , Nahar Zabun 
Published: October 2020

AbstractIntroductionClopidogrel and aspirin are at the base of treatment in conditions like arterial thrombosis and after patients have undergone percutaneous coronary intervention. But frequently found CYP2C19*2 and CYP2C19*17 polymorphisms and some variants of the ITGB3 gene cause alteration in the therapeutic effectiveness of this drug.MethodsOne thousand cardiovascular patients were recruited for each drug under study. Their blood was collected to analyze the genotype using PCR-RFLP and T-ARMS-PCR method for clopidogrel and aspirin respectively. The PCR products for clopidogrel were screened with agarose gel electrophoresis and then digested with SmaIfor CYP2C19*2 and Nsil-HF for CYP2C19*17. The digested products of clopidogrel and the ARMS-PCR product of aspirin were run on 2% AGE to analyze the polymorphisms.ResultsIn our outcome, the percentage of hetero and mutant homozygous people in CYP2C19*2 polymorphism (loss-of-function allele) was 64.1% and for CYP2C19*17 (gain-of-function allele) was 22.3%. For ITGB3 polymorphism, it was found that 84.1% of them belonged to the homozygous group while 15.6% was heterozygous and only 0.3% were mutant homozygous patients.ConclusionOur study findings were quite compatible with the results of some other studies in other ethnic groups. This phenomenon suggested for modification of dose or application of alternative generics in patients who are under the risk of therapeutic failure or toxicity produced by these drugs.
Joint evolution of mycorrhizal type, pollination, and seed dispersal mode in trees
Authors: Yamawo Akira , Ohno Misuzu 
Published: October 2020

AbstractAlthough tree diversity is fundamental to terrestrial ecosystems, the processes that generate it remain uncertain. Mycorrhizal type, pollination mode, and seed dispersal mode may be key drivers of tree diversity. We predicted that mycorrhizal symbiosis drove evolution of pollination and seed dispersal modes because arbuscular mycorrhizal (AM) associations would favour long-range seed or pollen dispersal owing to their negative plant–soil-feedback effects on conspecific individuals, and ectomycorrhizal (EcM) associations would favour short-range dispersal owing to their positive effects. We analysed evolutionary relationships among mycorrhizal type, seed dispersal mode, and pollination mode in 704 tree species and conducted a meta-analysis of the dispersal distances of the various seed dispersal and pollination modes. We found evidence of joint evolution of all three features. Most AM-associated trees had endozoochorous seed dispersal and biotic pollination and these dispersal modes had long dispersal distances, whereas most EcM-associated trees had anemochorous seed dispersal and wind pollination and these dispersal modes had relatively shorter dispersal distances. Overall, evolution of mycorrhizal type, seed dispersal mode, and pollination mode were linked, strongly suggesting that mycorrhizal symbiosis drives the evolution of seed and pollination modes and contributes to tree diversification.
Temporo-Parietal Cortex Involved in Modeling One’s Own and Others’ Attention
Authors: Guterstam Arvid , Bio Branden J , Wilterson Andrew I , Graziano Michael SA 
Published: October 2020

AbstractIn a traditional view, in social cognition, attention is equated with gaze and people track attention by tracking other people’s gaze. Here we used fMRI to test whether the brain represents attention in a richer manner. People read stories describing an agent (either oneself or someone else) directing attention to an object in one of two ways: either internally directed (endogenous) or externally induced (exogenous). We used multivoxel pattern analysis to examine how brain areas within the theory-of-mind network encoded attention type and agent type. Brain activity patterns in the left temporo-parietal junction (TPJ) showed significant decoding of information about endogenous versus exogenous attention. The left TPJ, left superior temporal sulcus (STS), precuneus, and medial prefrontal cortex (MPFC) significantly decoded agent type (self versus other). These findings show that the brain constructs a rich model of one’s own and others’ attentional state, possibly aiding theory of mind.Impact statementThis study used fMRI to show that the human brain encodes other people’s attention in enough richness to distinguish whether that attention was directed exogenously (stimulus-driven) or endogenously (internally driven).
Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer
Authors: Martins Filipe Correia , Couturier Dominique-Laurent , Santiago Ines de , Sauer Carolin Margarethe , Vias Maria , Angelova Mihaela , Sanders Deborah , Piskorz Anna , Hall James , Hosking Karen , Amirthanayagam Anumithra , Cosulich Sabina , Carnevalli Larissa , Davies Barry , Watkins Tom B. K. , Funingana Gabriel , Bolton Helen , Haldar Krishnayan , Latimer John , Baldwin Peter , Crawford Robin , Eldridge Matthew , Basu Bristi , Jimenez-Linan Mercedes , McGranahan Nicholas , Litchfield Kevin , Shah Sohrab P. , McNeish Iain , Caldas Carlos , Evan Gerard , Swanton Charles , Brenton James D. 
Published: October 2020

AbstractThe genomic complexity and heterogeneity of high-grade serous ovarian cancer (HGSOC) has hampered the realisation of successful therapies and effective personalised treatment is an unmet clinical need. Here we show that primary HGSOC spheroid models can be used to predict drug response and use them to demonstrate that somatic copy number alterations (SCNAs) in frequently amplified HGSOC cancer genes significantly correlate with gene expression and drug response. These genes are often located in areas of the genome with frequent clonal SCNAs. MYC chromosomal copy number is associated with ex-vivo and clinical response to paclitaxel and ex-vivo response to mTORC1/2 inhibition. Activation of the mTOR survival pathway in the context to MYC-amplified HGSOC is mostly due to increased prevalence of SCNAs in genes from the PI3K pathway. These results suggest that SCNAs encompassing driver genes could be used to inform therapeutic response in the context of clinical trials testing personalised medicines.
A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells
Authors: Doma Eszter , Mayer Isabella Maria , Brandstoetter Tania , Maurer Barbara , Grausenburger Reinhard , Menzl Ingeborg , Zojer Markus , Hoelbl-Kovacic Andrea , Carlsson Leif , Heller Gerwin , Kollmann Karoline , Sexl Veronika 
Published: October 2020

AbstractStudies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situationin vivo. We now report a robust method to generate and maintain LSK (lin-, Sca-1+, c-Kit+) cells which closely resemble MPP1 cells. HPCLSKreconstitute hematopoiesis in lethally irradiated recipient mice over more than eight months. Upon transformation with different oncogenes including BCR/ABL, FLT3-ITD or MLL-AF9 their leukemic counterparts maintain stem cell propertiesin vitroand recapitulate leukemia formationin vivo. The method to generate HPCLSKcan be applied to transgenic mice and we illustrate it for CDK6-deficient animals. Upon BCR/ABLp210transformation,Cdk6-/-HPCLSKsinduce disease with a significantly enhanced latency and reduced incidence, showing the importance of CDK6 in leukemia formation. Studies of the CDK6 transcriptome in murine HPCLSKand human BCR/ABL+cells have verified that certain pathways depend on CDK6 and have uncovered a novel CDK6-dependent signature, suggesting a role for CDK6 in leukemic progenitor cell homing. Loss of CDK6 may thus lead to a defect in homing. The HPCLSKsystem represents a unique tool for combinedin vitroandin vivostudies and enables the production of large quantities of genetically modifiable hematopoietic or leukemic stem/progenitor cells.Key pointsWe describe the generation of murine cell lines (HPCLSK) which reliably mimic hematopoietic/leukemic progenitor cells.Cdk6-/-BCR/ABLp210HPCLSKsuncover a novel role for CDK6 in homing.
On a class of non-local discrete boundary value problepm
Authors: Ourraoui Anass , Ayoujil Abdesslem 
Published: October 2020

PurposeIn this article, the authors discuss the existence and multiplicity of solutions for an anisotropic discrete boundary value problem inT-dimensional Hilbert space. The approach is based on variational methods especially on the three critical points theorem established by B. Ricceri.Design/methodology/approachThe approach is based on variational methods especially on the three critical points theorem established by B. Ricceri.FindingsThe authors study the existence of results for a discrete problem, with two boundary conditions type. Accurately, the authors have proved the existence of at least three solutions.Originality/valueAn other feature is that problem is with non-local term, which makes some difficulties in the proof of our results.