bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invar-based refractometer for pressure assessments
Authors: Silander Isak , Forssén Clayton , Zakrisson Johan , Zelan Martin , Axner Ove 
Published: April 2020

Gas modulation refractometry (GAMOR) is a methodology that can mitigate fluctuations and drifts in refractometry. This can open up for the use of non-conventional cavity spacer materials. In this paper, we report a dual-cavity system based on Invar that shows better precision for assessment of pressure than a similar system based on Zerodur. This refractometer shows for empty cavity measurements, up to

10
4

s, a white noise response (for

N

2

) of 3 mPa

s

1

/

2

. At 4303 Pa, the system has a minimum Allan deviation of 0.34 mPa (0.08 ppm) and a long-term stability (24 h) of 0.7 mPa. This shows that the GAMOR methodology allows for the use of alternative cavity materials.
‘Our dream is simple: Peace, safe and freedom’: Regime-critical activism and artistic expression by Syrians in Denmark and Sweden
Authors: Wessels Josepha Ivanka (Joshka) 
Published: April 2020

Abstract
This article seeks to understand mediatized dynamics of regime-critical activism and cultural performances by Syrians in Europe. The focus of this research is on the Öresund-region between Denmark and Sweden. Sweden was the first country in Europe to give immediate permanent residence to Syrian refugees. It initially received most of the Syrian refugees in 2015. After the arrival of large groups of Syrians at Malmö station in that year, a growing network of volunteers responded to the influx of refugees. Syrians started to build relationships with local activists and have since joined in organizing publicly mediated events, creating a new landscape for creative industries and performance arts in the region. Applying a protest communication ecology approach, I use a wide definition of media which includes the aesthetics of street demonstrations, performance arts and music, mediated and communicated through digital online platforms. I apply an adjusted concept of communitas, including digital media and online communication as analytical concept to observe and describe not only how communitas is re-formed between Syrian refugees after arrival but also how it emerges between Syrians and local hosts.
ANALISIS USABILITAS PADA APLIKASI MANDIRI ONLINE
Authors: Wibowo Astrid Wahyu Adventri 
Published: April 2020

Internet banking atau mobile banking adalah salah satu bentuk aplikasi yang berbasis internet yang dapat digunakan sebagai pintu gerbang menuju dunia perbankan masa depan. Dalam memberikan layanan, pihak bank tidak ingin mengecewakan nasabahnya karena aplikasi internet banking yang sulit digunakan sehingga mengakibatkan nasabah gagal dalam mencari informasi atau gagal melakukan aktivitas perbankan. Melihat pentingnya usabilitas sebuah aplikasi, maka dilakukan penelitian terhadap aplikasi Mandiri Online untuk mengetahui kelayakan dari aplikasi tersebut, mengidentifikasi permasalahan usabilitas, serta menyusun rekomendasi perbaikan. Aplikasi tersebut diuji menggunakan System Usability Scale (SUS) dan pendekatan heuristic evaluation dengan responden sebanyak 40 orang untuk metode SUS dan 5 evaluator dengan kriteria single-expert untuk pendekatan heuristic evaluation. Hasil pengujian aplikasi Mandiri Online dengan instrumen SUS adalah sebesar 79,6 yang berarti aplikasi Mandiri Online dinyatakan dapat diterima (acceptable), termasuk dalam grade B dengan rating good. Dari penelitian ini juga diketahui bahwa terdapat beberapa permasalahan usabilitas mayor yang harus segera diperbaiki dan harus diberi prioritas tinggi. Dalam menyelesaikan permasalahan tersebut membutuhkan beberapa usaha, seperti menambahkan fitur search untuk mencari nama bank, membuat pengelompokkan instansi pada menu multipayment, membuat atau menambahkan panduan penggunaan atau flowchart penggunaan Mandiri Online, dan menambahkan fitur help pada Mandiri Online. Abstract[Title: Usability Analysis of Mandiri Online Apllication] Internet banking or mobile banking is a form of internet-based application that can be used as a gateway to the future of banking. In providing services, banks won’t to let down their customers because of internet banking applications are difficult to use, resulting in failure to find information or fail to conduct banking activities. Seeing the importance of application usability, a study of Mandiri Online application was conducted to find out the appropriatness of the application, identify usability issues, and construct recommendations for application improvement. This application was tested using the System Usability Scale (SUS) and heuristic evaluation approach with 40 respondents for the SUS and 5 evaluators with single-expert criteria for the heuristic evaluation. The result of testing the Mandiri Online application with the SUS instrument amounted to 79,6 which means this application was declared acceptable, included in grade B, and with a good rating. From this study it is also known that there are some major usability problems that must be corrected immediately and must be given high priority. In solving these problems requires several efforts, such as adding search feature to search the bank’s name, creating agency groups on multipayment menu, creating or adding usage guidelines or flowcharts for using Mandiri Online, and adding help feature to Mandiri Online.Keywords: Heuristic Evaluation; System Usability Scale; Usability
The Effect of a Single Session of Plyometric Training Per Week on Fitness Parameters in Professional Female Soccer Players: A Randomized Controlled Trial
Authors: Nonnato Andrea , Hulton Andrew T. , Brownlee Thomas E. , Beato Marco 
Published: April 2020

Abstract
Nonnato, A, Hulton, AT, Brownlee, TE, and Beato, M. The effect of a single session of plyometric training per week on fitness parameters in professional female soccer players. A randomized controlled trial. J Strength Cond Res 36(4): 1046–1052, 2022—As the interest and popularity of female soccer has increased over the last few decades, there still lacks research conducted with the elite population, specifically ecological training interventions during the competitive season. Therefore, the aim of this study was to compare the effectiveness of 12 weeks (undertaken once a week) of plyometric (PLY) training on physical performance in professional female soccer players during the season. Using a randomized controlled trial design, 16 players were included in the current study (mean ± SD; age 23 ± 4 years, weight 60.3 ± 4.9 kg, height 167 ± 3.7 cm) and randomized in PLY (n = 8) and Control groups (CON, n = 8), respectively. Squat jump (SJ), counter movement jump (CMJ), long jump (LJ), single-leg triple jump distance test (triple jump test), changes of direction 505 test (505-COD), and sprint 10 and 30 m were performed before and after 12 weeks of PLY training. Significant within-group differences were found in triple jump test dominant (p = 0.031, effect size [ES] = moderate) and nondominant limb (p = 0.021, ES = moderate) and sprint 10 m (p = 0.05, ES = large), whereas the CON did not report any positive variation. However, neither group reported significant variation in SJ, CMJ, LJ, 505-COD, and sprint 30 m (underlining the difficulties in obtain meaningful variation in season). These findings have strong practical applications because this study showed for the first time that a single session a week of plyometric training can significantly increase sport-specific fitness parameters in professional female soccer players during the season.
The Effect of Overreaching on Neuromuscular Performance and Wellness Responses in Australian Rules Football Athletes
Authors: Campbell Patrick G. , Stewart Ian B. , Sirotic Anita C. , Minett Geoffrey M. 
Published: April 2020

Abstract
Campbell, PG, Stewart, IB, Sirotic, AC, and Minett, GM. Title: The effect of overreaching on neuromuscular performance and wellness responses in Australian rules football athletes. J Strength Cond Res 34(6): 1530–1538, 2020—This study seeks to evaluate the effect of periodized fluctuations in training load on wellness and psychological questionnaires, perceived exertion, performance, and neuromuscular measures in team-sport athletes. Thirteen amateur Australian rules football athletes completed 6 weeks of periodized training, consisting of 2-week normal training (NT), intensified training (IT), and taper training (TT). Training sessions were quantified using global positioning system devices, heart-rate, and session rating of perceived exertion (sRPE), with wellness (general soreness, sleep quality/quantity, readiness to train, fatigue, stress, mood, and motivation) questionnaires collected daily. Psychological (Recovery-Stress Questionnaire for Athletes) and physical performance (countermovement jump, cycle ergometer peak power, 30-m sprint, and 2-km time trial) markers were measured after each training period. Perceived (sRPE) and mechanical loading were higher for IT than NT, and IT than TT (p < 0.03; d = 0.65–25.34). Cycle ergometer peak power, 30-m sprint, 2-km time trial, and countermovement jump height showed reductions in performance after IT compared to initial testing (p < 0.02; d = 0.51–1.46), with subsequent increases in performance after TT (p < 0.04; d = 0.66–2.27). Average wellness was higher during NT compared to IT (p = 0.005; d = 1.11). Readiness to train did not significantly differ from NT to IT or TT (p < 0.55; d = <0.59); however, readiness to train did improve during TT after the IT (p = 0.01; d = 1.05). The disturbances in performance, perceptual, and mood states may indicate a state of functional overreaching. The findings suggest that an averaged wellness score may be useful in potentially identifying overreaching. However, despite the popularity of wellness in monitoring systems, these measures overall demonstrated a limited capacity to differentiate between periodized fluctuations in load.
Nestin Selectively Facilitates the Phosphorylation of the Lissencephaly-Linked Protein Doublecortin (DCX) by cdk5/p35 to Regulate Growth Cone Morphology and Sema3a Sensitivity in Developing Neurons
Authors: Bott Christopher J. , McMahon Lloyd P. , Keil Jason M. , Yap Chan Choo , Kwan Kenneth Y. , Winckler Bettina 
Published: April 2020

Nestin, an intermediate filament protein widely used as a marker of neural progenitors, was recently found to be expressed transiently in developing cortical neurons in culture and in developing mouse cortex. In young cortical cultures, nestin regulates axonal growth cone morphology. In addition, nestin, which is known to bind the neuronal cdk5/p35 kinase, affects responses to axon guidance cues upstream of cdk5, specifically, to Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, and changes in microtubules and actin filaments are well studied. In contrast, the roles of intermediate filament proteins in this process are poorly understood, even in cultured neurons. Here, we investigate the molecular mechanism by which nestin affects growth cone morphology and Sema3a sensitivity. We find that nestin selectively facilitates the phosphorylation of the lissencephaly-linked protein doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected by nestin. We uncover that this substrate selectivity is based on the ability of nestin to interact with DCX, but not with other cdk5 substrates. Nestin thus creates a selective scaffold for DCX with activated cdk5/p35. Last, we use cortical cultures derived fromDcxKO mice to show that the effects of nestin on growth cone morphology and on Sema3a sensitivity are DCX-dependent, thus suggesting a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating the intracellular kinase signaling environment in developing neurons. The sex of animal subjects is unknown.SIGNIFICANCE STATEMENTNestin, an intermediate filament protein highly expressed in neural progenitors, was recently identified in developing neurons where it regulates growth cone morphology and responsiveness to the guidance cue Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, but the roles of intermediate filaments in this process are poorly understood. We now report that nestin selectively facilitates phosphorylation of the lissencephaly-linked doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected. This substrate selectivity is based on preferential scaffolding of DCX, cdk5, and p35 by nestin. Additionally, we demonstrate a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating intracellular kinase signaling in developing neurons.
Cognitive Effort Modulates Connectivity between Dorsal Anterior Cingulate Cortex and Task-Relevant Cortical Areas
Authors: Aben Bart , Buc Calderon Cristian , Van den Bussche Eva , Verguts Tom 
Published: April 2020

Investment of cognitive effort is required in everyday life and has received ample attention in recent neurocognitive frameworks. The neural mechanism of effort investment is thought to be structured hierarchically, with dorsal anterior cingulate cortex (dACC) at the highest level, recruiting task-specific upstream areas. In the current fMRI study, we tested whether dACC is generally active when effort demand is high across tasks with different stimuli, and whether connectivity between dACC and task-specific areas is increased depending on the task requirements and effort level at hand. For that purpose, a perceptual detection task was administered that required male and female human participants to detect either a face or a house in a noisy image. Effort demand was manipulated by adding little (low effort) or much (high effort) noise to the images. Results showed a network of dACC, anterior insula (AI), and intraparietal sulcus (IPS) to be more active when effort demand was high, independent of the performed task (face or house detection). Importantly, effort demand modulated functional connectivity between dACC and face-responsive or house-responsive perceptual areas, depending on the task at hand. This shows that dACC, AI, and IPS constitute a general effort-responsive network and suggests that the neural implementation of cognitive effort involves dACC-initiated sensitization of task-relevant areas.SIGNIFICANCE STATEMENTAlthough cognitive effort is generally perceived as aversive, its investment is inevitable when navigating an increasingly complex society. In this study, we demonstrate how the human brain tailors the implementation of effort to the requirements of the task at hand. We show increased effort-related activity in a network of brain areas consisting of dorsal anterior cingulate cortex (dACC), anterior insula, and intraparietal sulcus, independent of task specifics. Crucially, we also show that effort-induced functional connectivity between dACC and task-relevant areas tracks specific task demands. These results demonstrate how brain regions specialized to solve a task may be energized by dACC when effort demand is high.
The Predictive Value of Early Changes in 18F-Fluoroestradiol Positron Emission Tomography/Computed Tomography During Fulvestrant 500 mg Therapy in Patients with Estrogen Receptor-Positive Metastatic Breast Cancer
Authors: He Min , Liu Cheng , Shi Qin , Sun Yuyun , Zhang Yongping , Xu Xiaoping , Yuan Huiyu , Zhang Yingjian , Liu Yin , Liu Guangyu , Di Genhong , Yang Zhongyi , Wang Zhonghua , Shao Zhiming 
Published: April 2020

Abstract

Background
The aim of this study was to investigate the predictive value of early changes in 18F-fluoroestradiol (FES) positron emission tomography (PET)/computed tomography (CT) during fulvestrant 500 mg therapy in patients with estrogen receptor (ER)-positive metastatic breast cancer.

Materials and Methods
Patients underwent 18F-FES PET/CT scans at both baseline (scan 1) and day 28 (scan 2). The maximum standardized uptake value (SUVmax) of all metastatic sites was determined in each scan, and the percentage reduction in SUVmax (ΔSUVmax) was calculated as [(SUVmax on scan 1-SUVmax on scan 2)/ SUVmax on scan 1] * 100%.

Results
In total, 294 18F-FES-positive lesions from 36 patients were identified. The 18F-FES SUVmax varied widely among lesions (median 5.7; range 1.8–32.4) and patients (median 5.1; range 2.5–13.2). After treatment, the median SUVmax among lesions and patients was 2.1 and 2.1, respectively. The ΔSUVmax ranged from −5.1% to 100%, with a median reduction of 61.3%. Using receiver operating characteristic analysis, the optimal cutoff point to discriminate patients who could derive clinical benefit from fulvestrant was determined to be 38.0%. Patients with a median ΔSUVmax ≥38.0% experienced significantly longer progression-free survival (PFS) than those with ΔSUVmax &lt;38.0% (28.0 months vs. 3.5 months, p = .003). Multivariate analysis demonstrated that ΔSUVmax ≥38.0% was an independent predictor of PFS benefit in patients receiving fulvestrant therapy.

Conclusion
Changes in SUVmax measured by serial imaging of 18F-FES PET/CT could be used early to predict PFS benefit in patients receiving fulvestrant therapy.

Implications for Practice
The aim of this study was to evaluate the role of 18F-fluoroestradiol (FES) positron emission tomography (PET)/computed tomography (CT) in predicting response to fulvestrant 500 mg therapy in patients with hormone receptor-positive/human epidermal growth receptor 2–negative metastatic breast cancer. This study highlights the utility of FES PET/CT as a predictive factor to discriminate patients who might benefit from fulvestrant. Moreover, these findings showed that this molecular imaging technique might be a potential tool for physicians to make individualized treatment strategies.
Clinical Behavior and Treatment Response of Epstein-Barr Virus-Positive Metastatic Gastric Cancer: Implications for the Development of Future Trials
Authors: Corallo Salvatore , Fucà Giovanni , Morano Federica , Salati Massimiliano , Spallanzani Andrea , Gloghini Annunziata , Volpi Chiara Costanza , Trupia Desirè Viola , Lobefaro Riccardo , Guarini Vincenzo , Milione Massimo , Cattaneo Laura , Antista Maria , Prisciandaro Michele , Raimondi Alessandra , Sposito Carlo , Mazzaferro Vincenzo , de Braud Filippo , Pietrantonio Filippo , Di Bartolomeo Maria 
Published: April 2020

Abstract

Background
Epstein-Barr virus (EBV)-positive gastric cancers (GCs) have been recently identified as a molecular subgroup showing excellent outcomes after surgery for early-stage disease and responsiveness to immune checkpoint inhibitors (ICIs) for metastatic stage. No data are available on the prevalence, clinical characteristics, and prognosis of this subgroup of GCs in the metastatic setting.

Materials and Methods
In this cohort study, we assessed the impact of EBV status in patients with metastatic GC treated with chemotherapy at two Italian institutions.

Results
Among the 175 cases analyzed, only 7 (4%) were EBV positive and all showed long-lasting and even complete responses to first-line chemotherapy with fluorouracil and platinum and a significantly better survival compared with EBV-negative patients (3-year overall survival: 80% vs. 20.1%; hazard ratio: 0.12).

Conclusion
If confirmed in larger data sets, our results may give a strong rationale for investigating the addition of ICIs to chemotherapy, in order to maximize the chance of achieving durable and complete responses in this uncommon subtype of GC.

Implications for Practice
To date, no data are available on the prevalence and clinical characteristics of patients with Epstein-Barr virus (EBV)-positive metastatic gastric cancer (GC), a specific subtype of GC showing excellent outcomes after radical surgery in early-stage disease and responsiveness to immune checkpoint inhibitors (ICIs). This cohort study showed that patients with EBV-positive GC who did not receive ICIs had exceptional, long-lasting, and even complete responses to first-line chemotherapy with fluorouracil and platinum and a significantly better survival compared with EBV-negative patients. If confirmed in larger series, these results may give a strong rationale for investigating the combination of chemotherapy and ICIs to achieve durable and potentially complete response in this uncommon subtype of GC.
FDA Accelerated Approval of Pembrolizumab for Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma
Authors: Bradford Diana , Demko Suzanne , Jin Susan , Mishra-Kalyani Pallavi , Beckles Aaliyah R. , Goldberg Kirsten B. , Lemery Steven , Ward Ashley , Keegan Patricia , Pazdur Richard 
Published: April 2020

Abstract

On December 19, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA, Merck & Co. Inc., Whitehouse Station, NJ) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). Approval was based on Cancer Immunotherapy Trials Network protocol 9, also known as KEYNOTE-017 (NCT02267603), a multicenter, nonrandomized, open-label trial that enrolled 50 patients with recurrent locally advanced or metastatic MCC who had not received prior systemic therapy for their advanced disease. The major efficacy outcome measures were overall response rate (ORR) and response duration assessed by blinded independent central review per RECIST 1.1. The ORR was 56% (95% confidence interval: 41, 70) with a complete response rate of 24%. The median response duration was not reached. Among the 28 patients with responses, 96% had response durations of greater than 6 months and 54% had response durations of greater than 12 months. The most common adverse reactions of pembrolizumab reported in at least 20% of patients who received pembrolizumab as a single agent were fatigue, musculoskeletal pain, decreased appetite, pruritus, diarrhea, nausea, rash, pyrexia, cough, dyspnea, constipation, pain, and abdominal pain.

Implications for Practice
This report presents key information on the basis for the Food and Drug Administration's accelerated approval of pembrolizumab for the treatment of recurrent locally advanced or metastatic Merkel cell carcinoma, including efficacy and safety information. This approval provides patients and physicians with an additional treatment option for this aggressive and life-threatening carcinoma.
Remarks by L.G. Rawl at the 1989 SPE Annual Technical Conference and Exhibition
Authors: Rawl L. G. 
Published: April 2020

Abstract
Thank you. It's a pleasure to return to texas/ where i have spent much of my career, and to address this international conference.
Your theme is appropriate, and certainly timely. There is no doubt that "excellence" will indeed be "essential for the 1990s."
Our industry has long provided quality products at competitive costs to an expanding world economy. In doing so, we’ve met countless technical challenges in finding, developing, processing, and marketing energy supplies from some of the most difficult geologic and geographic settings in the world.