bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and Validation of a Prognostic Signature for Lung Adenocarcinoma Based on Metabolism-related Genes
Authors: Wang Zhihao , Embaye Kidane Siele , Yang Qing , Qin Lingzhi , Zhang Chao , Liu Liwei , Zhan Xiaoqian , Zhang Fengdi , Wang Xi , Qin Shenghui 
Published: November 2020

Abstract
Background: Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metabolism-related genes(MRGs).Methods: The gene sequencing data of LUAD samples with clinical information and the metabolism-related gene set were obtained from The Cancer Genome Atlas (TCGA) and Molecular Signatures Database (MSigDB), respectively. The differentially expressed MRGs were identified by Wilcoxon rank sum test. Then, univariate Cox regression analysis were performed to identify MRGs that related to overall survival(OS). A prognostic signature was developed by multivariate Cox regression analysis. Furthermore, the signature was validated in the GSE31210 dataset. In addition, a nomogram that combined the prognostic signature was created for predicting the 1-, 3- and 5-year OS of LUAD.The accuracy of the nomogram prediction was evaluated using a calibration plot. Finally, cox regression analysis was applied to identify the prognostic value and clinical relationship of the signature in LUAD.Results: A total of 116 differentially expressed MRGs were detected in the TCGA dataset. We found that 12 MRGs were most significantly associated with OS by using the univariate regression analysis in LUAD. Then, multivariate Cox regression analyses were applied to construct the prognostic signature, which consisted of six MRGs (ALDOA, CAT, ENTPD2, GNPNAT1, LDHA, and TYMS). The prognostic value of this signature was further successfully validated in the GSE31210 dataset. Furthermore, the calibration curve of the prognostic nomogram demonstrated good agreement between the predicted and observed survival rates for each of OS. Further analysis indicated that this signature could be an independent prognostic indicator after adjusting to other clinical factors. The signature was found to be associated with various clinicopathological features. Finally, we confirmed six MRGs protein and mRNA expression in six lung cancer cells and firstly found that ENTPD2 might played an important role on lung adenocarcinoma cell lines clone formation and migration.Conclusions: We established a prognostic signature based on MRGs for LUAD and validated the performance of the model, which may provide a promising tool for the diagnosis and prognosis in patients with LUAD.
The Impact of COVID-19 Pandemic on the Health-Seeking Behaviour of an Asian Population with Acute Respiratory Infections in a Densely Populated Community
Authors: JaneTan Hwee Mian , Tan Mui Suan , Ying Chang Zi , Tan Kee Tung , Ee Adrian , Ng Chee Chin David , Hwang William , Koh Eileen , Low Sarah , Tan Ngiap Chuan 
Published: November 2020

Abstract
BackgroundThe COVID-19 pandemic led to the implementation of various non-pharmaceutical interventions (NPI) as the Singapore government escalated containment efforts from DORSCON Orange to Circuit Breaker. NPI include mandatory mask wearing, hand hygiene, social distancing, and closure of schools and workplaces. Considering the similar mode of transmission of COVID-19 and other pathogens related to acute respiratory infections (ARI), the effects of NPI are postulated to decrease ARI attendances in the community. The uptake of respiratory-related vaccinations are surrogate indicators of the health-seeking behaviour amidst the pandemic. This study primarily aims to determine the effect of Singapore’s NPI on ARI attendances across a cluster of polyclinics. The secondary aim is to determine the impact of COVID-19 outbreak on the uptake of influenza and pneumococcal vaccinations.MethodsThe effect of the nation-wide measures on the health-seeking behaviour of the study population was examined over three periods: (1) 9 weeks prior to the start of Circuit Breaker (DORSCON Orange period), (2) 8 weeks during the Circuit Breaker, and (3) 9 weeks after easing of Circuit Breaker. Data on ARI attendances and respiratory-related vaccinations uptake for the corresponding periods in 2019 were also extracted for comparison and to assess the seasonal variations of ARI. The average weekly workday ARI attendances were compared with those of the preceding week using Wilcoxon signed rank test.ResultsARI attendances dropped steadily throughout the study period and were 50%-80% lower than in 2019 since Circuit Breaker. They remained low even after Circuit Breaker ended. Positivity rate for influenza-like illnesses samples in the community was 0.0% from the last week of Circuit Breaker to end of study period. Respiratory vaccinations uptake was higher in 2020 than 2019.ConclusionsNPI and public education measures during DORSCON Orange and Circuit Breaker periods appear to be associated with the health-seeking behaviour of the public. Changing levels of perceived susceptibility, severity, benefits and barriers, and widespread visual cues based on the Health Belief Model may account for this change. Understanding the impact of NPI and shifts in the public’s health-seeking behaviour can aid in the planning of future pandemic responses.
Children with asymptomatic coronavirus disease-19 (COVID-19): Insights from 2-to 15-year-old cases
Authors: Lombardi Mariella , Caro Dominique , Brett Pascal , Wiggins Silvia 
Published: November 2020

Abstract
Summary of clinical characteristics of 25 confirmed cases of COVID-19 in children aged between 2 and 15 years, with at least one infected member in their family, are reported and discussed herein. Eighteen patients are asymptomatic, and seven have mild complications without requiring mechanical ventilation or intense unit care (ICU). Results suggested that children with infected family members are very likely to be asymptomatically infected.
Progressing Towards Environmental Health Targets in China: A Systematic Review of Achievements in Air and Water Pollution under the “Ecological Civilization and the Beautiful China” Dream
Authors: Antwi Henry Asante 
Published: November 2020

Abstract
Despite the positive effect of industrialization on health and quality of life indicators across the globe, it is also responsible for the release of chemical toxins into the environment and has nurtured numerous environmental disasters with severe health effects. China alone produces more than a third of carbon emissions in the world and currently has the second highest number of pollution-related deaths, after India. There is no issue that underscores the challenges of environmental crisis in China than the gradual acceptance of the existence of the cancer villages. These are entire towns that have been completely written off as so polluted that simply living there is synonymous with high rate of cancer risk. For years, residents and advocacy groups in villages such as Wuli, Yanglingang, Yangqiao and additional 459 identified cancer villages have waged a desperate war to turn the attention of government to the high risk of stomach, liver, kidney and colon cancer in these areas located near heavy industrial complexes. China responded by promoting an ecological civilization and a beautiful China dream as its sustainability blueprint in 2012. Today, this blueprint has been engraved into the national ideology for socio-economic and political orientation. This review therefore revisits the progress made towards environmental health targets under China’s sustainable development strategy. The study systematic explores the extant works on air and water pollution since the “Ecological Civilization and the Beautiful China” Dream.
A mixed-methods evaluation of the impact of a person-centered family planning intervention for community health workers on family planning outcomes in India
Authors: Diamond-Smith Nadia , McDonell Claire , Sahu Ananta Basudev , Roy Kali Prasad , Giessler Katie 
Published: November 2020

Abstract
Background: Person-centered quality for family planning has been gaining increased attention, yet few interventions have focused on this, or measured associations between person-centered quality for family planning and family planning outcomes (uptake, continuation, etc.). In India, the first point of contact for family planning is often the community health care worker, in this case, Accredited Social Health Activists (ASHAs). Methods: In this study, we evaluate a training on person-centered family planning as an add-on to a training on family planning provision for urban ASHAs in Varanasi, India in 2019 using mixed methods. We first validate a scale to measure person-centered family planning in a community health worker population and find it to be valid. Higher person-centered family planning scores are associated with family planning uptake. Results: Comparing women who saw intervention compared to control ASHAs, we find that the intervention had no impact on overall person-centered family planning scores. Women in the intervention arm were more likely to report that their ASHA had a strong preference about what method they choose, suggesting that the training increased provider pressure. However, qualitative interviews with ASHAs suggest that they value person-centered care for their interactions and absorbed the messages from the intervention.Conclusions: More research is needed on how to intervene to change behaviors related to person-centered family planning. This study received IRB approval from the University of California, San Francisco (IRB # 15-25950) and was retrospectively registered at clinicaltrials.gov (NCT04206527)
Treatment of Volar Defects of the Finger using Dorsal Digital–metacarpal Flap Versus Free Medial Plantar Artery Flap: A Comparative Study
Authors: Liu Quanzhe , Guo Wenlai , Qu Wenrui , Ou Xiaolan , Li Rui , Tian Heng 
Published: November 2020

Abstract
Background: The treatment of defects on the volar surface of the finger has been scarcely reported, and its utility for digital resurfacing remains unclear. This study compared the outcomes of free medial plantar artery flap (MPAF) and dorsal digital–metacarpal flap (DDMF) in finger reconstruction.Methods: This retrospective cohort study included 24 patients with soft-tissue defects on the volar surface of the finger from March 2014 to March 2017. The patients were divided into two groups: the MPAF group and the DDMF group. The operation time, complications, such as flap necrosis, graft loss, infection, paresthesia, and donor-site morbidity, as well as two-point discrimination (2-PD) were carefully recorded. The Michigan Hand Outcomes Questionnaire was used for conduct follow-up assessment.Results: After more than 12 months of follow-up, the MPAF group had a longer operative time compared with DDMF group, but there was no significant difference between postoperative complications and 2-PD test result in patients without nerve injury. And in terms of overall function, Modified VSS score and 2-PD test (the patients with nerve injury), There were relatively obvious statistical differences, MPAF was superior to DDMF (p < 0.005).Conclusion: MPAF and DDMF are reliable for reconstruction of the volar surface of the finger; however, MPAF offers better functional outcomes and is associated with a lower incidence of postoperative complications.
A systematically collated library of prescribing safety indicators for people with chronic kidney disease
Authors: Smith Fiona , Hayward Samantha , Hole Barnaby , Kimpton George , Sluman Christine , Whiting Penny , Caskey Fergus 
Published: November 2020

Abstract
BackgroundPeople with chronic kidney disease (CKD) have high levels of co-morbidity and polypharmacy placing them at increased risk of prescribing-related harm. Tools for assessing prescribing safety in the general population using prescribing safety indicators (PSIs) have been established. However, people with CKD pose different prescribing challenges to people without kidney disease. Therefore, PSIs designed for use in the general population may not include all PSIs relevant to a CKD population. The aim of this study was to systematically collate a library of PSIs relevant to people with CKD. MethodsA systematic literature search identified papers reporting PSIs. CKD-specific PSIs were extracted and categorised by Anatomical Therapeutic Chemical (ATC) classification codes. Duplicate PSIs were removed to create a final list of CKD-specific PSIs. Results 9,852 papers were identified by the systematic literature search, of which 511 proceeded to full text screening and 196 papers were identified as reporting PSIs. Following categorisation by ATC code and duplicate removal, 841 unique PSIs formed the final set of CKD-specific PSIs. The five ATC drug classes containing the largest proportion of CKD-specific PSIs were: Cardiovascular system (26%); Nervous system (13.4%); Blood and blood forming organs (12.4%); Alimentary and metabolism (12%); and Anti-infectives for systemic use (11.3%).Conclusion CKD-specific PSIs could be used alone or alongside general PSIs to assess the safety and quality of prescribing within a CKD population.
Implementation of a complex health services intervention in long-term care homes: a process evaluation using focus groups
Authors: Warth Rieka von der , Kaiser Vanessa , Reese Christina , Brühmann Boris A. , Farin-Glattacker Erik 
Published: November 2020

Abstract
BackgroundWith rising numbers of the elderly living in nursing homes in Germany, the need for on-site primary care is on the increase. A lack of primary care in nursing homes can lead to unnecessary hospitalization, higher mortality, and morbidity in the elderly. The CoCare (“coordinated medical care”) project has therefore implemented a complex health intervention in nursing homes, using inter alia, regular medical rounds, a shared patient medical record and medication checks, aiming to improve the coordination of medical care. This study reports upon the results of the process evaluation assessing the perceived acceptance and barriers of the project by stakeholders.MethodsFocus group interviews were held between the fall of 2018 and the fall of 2019 with nurses, general practitioners and GP´s assistants working in or consulting a participating nursing home. A semi-structured modular guideline was used to ask participants about their opinion on different aspects of CoCare. Focus groups were analyzed using qualitative content analysis. ResultsIn total, N=11 focus group interviews with N=74 participants were conducted. Eleven main themes with four subthemes were identified, encompassing all aspects of CoCare. The overall acceptance of the project was good. Participants elected to speak most often about the project modules “communication and collaboration” and “medical rounds”, with participants concluding that CoCare had prevented unnecessary hospitalizations. The main barriers were understaffing and complexity of the program.ConclusionImplementation of CoCare in nursing homes is complex and presents some barriers. However, the overall acceptance was good and participants reported the first positive results. Furthermore, the project provides a good structure to overcome potential barriers. However, some adaptions to the implementation process should be made.
Inguinal hernias in patients on continuous ambulatory peritoneal dialysis: is tension-free mesh repair feasible?
Authors: Chi Qiyu , Shi Zheng , Zhang Zhibo , Lin Chunzhong , Liu Guozhong , Weng Shangeng 
Published: November 2020

Abstract
Background: Continuous ambulatory peritoneal dialysis (CAPD), which often causes a common complication such as abdominal wall hernia, is a prevalent alternative therapy for end-stage renal failure patients. However, relevant studies are somewhat rare, and the peritoneal dialysis (PD) protocol during the perioperative period is still controversial. The aim of this study was to evaluate the effectiveness and perioperative management of tension-free mesh repair for inguinal hernias in CAPD patients.Methods: Between January 2013 and December 2019, 18 CAPD patients with 20 inguinal hernias who underwent tension-free mesh repair were retrospectively analyzed. Data on demographics, perioperative features, the perioperative dialysis protocol and surgical complications were collected and assessed.Results: All hernias were diagnosed after the start of CAPD, and the median duration from PD onset to hernia formation was 16 months (2-61 months). All patients underwent successful tension-free mesh repair, including 17 Lichtenstein and 3 anterior Kugel procedures. The median operation time was 62.5 min, and the median postoperative hospital stay was 3 days. Fifteen patients received low-exchange volumes and high-frequency exchanges from 1-3 days after surgery for 2 weeks with gradual resumption of the original CAPD regimen within 4 weeks. Complications included seroma (n = 2) and hematoma (n = 1). No wound or mesh infection or recurrence occurred during the follow-up period.Conclusions: Tension-free mesh repair is safe and feasible for inguinal hernias in CAPD patients, The Lichtenstein mesh repair should be the first choice, and anterior Kugel repair may be considered an effective procedure. Bridging hemodialysis seems unnecessary except for emergency surgery.
Association between renal function and platelet reactivity during aspirin therapy in elderly patients with atherosclerotic cardiovascular disease
Authors: Liang Wenyi , Zhang Peng , Liu Meilin 
Published: November 2020

Abstract
Background: Aspirin is the key treatment in the secondary prevention of atherosclerotic cardiovascular disease. High on-treatment platelet reactivity (HTPR) to aspirin has been reported to partially account for the enhanced risk of thrombotic events. In particular, HTPR has been described more frequently among elderly patients. The aim of this study was to identify the clinical and biological factors associated with HTPR in a real-life elderly population.Methods: In this retrospective study, elderly patients with atherosclerotic cardiovascular disease on regular aspirin treatment were enrolled. Cardiovascular risk factors, routine biological parameters, comorbidities, and concomitant medications were recorded. The upper quartile of the platelet aggregation rate, determined by light transmission aggregometry with arachidonic acid, was defined as the HTPR group.Results: A total of 304 patients were included (mean age 77 ± 8 years, 76% men). Patients in the HTPR group were older than the patients in the non-HTPR group (mean age: 79 ± 7 vs. 76 ± 8 years, p = 0.008). Patients with moderately decreased estimated glomerular filtration rate (eGFR) had a higher frequency of HTPR than patients with slightly decreased eGFR or normal eGFR (35.8%, 22.5%, 12.2%, respectively, p < 0.05). In multivariate analysis, an independent risk factor for HTPR was the eGFR (OR: 0.984, 95% CI: 0.980-0.988, p < 0.001).Conclusions: Advanced age and decreased eGFR are correlated with poor pharmacodynamic response to aspirin. Antiplatelet strategy in elderly patients with atherosclerotic cardiovascular disease should be driven by an individualized approach, especially in patients with impaired renal function.
Macroscopic Assembled Graphene for Silicon Mid-Infrared Photodetectors
Authors: Gao Chao , Peng Li , Du Sichao , Liu Lixiang , Bodepudi Srikrishna , Li Lingfei , Liu Wei , Cong Xin , Lai Runchen , Fang Wenzhang , Cao Xiaoxue , Liu Xinyu , Abid Muhammad , Lv Jianhang , Liu Junxue , Jin Shengye , Wu Kaifeng , Zhou Qiaohui , Zhu Haiming , Lin Miao-Ling , Tan Ping-Heng , Xiong Qihua , Wang Xiaomu , Hu Weida , Duan Xiangfeng , Yu Bin , Yin Wenyan , Xu Zhen , Xu Yang 
Published: November 2020

Abstract
Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot-electrons in a broad wavelength range from ultraviolet to terahertz. However, the limited absorption (~2.3%) and serious backscattering of hot-electrons associated with single-layer graphene result in inadequate quantum yields, impeding their practically broadband photodetection, especially in the mid-infrared range. Here, we report a macroscopic assembled graphene (MAG)/silicon heterojunction for ultrafast mid-infrared photodetection. The highly crystalline 2-inch scale MAG with tunable thickness from 10 to 60 nm is produced by scalable wet-assembly of commercial graphene oxide followed by thermal annealing. The MAG/Si Schottky diode exhibits broadband photodetection capability in 1-10 μm at room temperature with fast response (120-130 ns, 4 mm2 window) and high detectivity (1011 to 106 Jones), outperforming single-layer graphene/Si photodetectors by 2 to 8 orders in transient photocurrent. This optoelectronic performance is attributed to the superior advantages of MAG (~40% of light absorption, ~23 ps of carrier relaxation time, and high quasi-equilibrated hot-carrier-multiplication gain), atomic-scale contact interface of MAG and silicon, and impact-ionization avalanche gain (~100 times) from silicon. The MAG provides a long-range platform to understand the hot-carrier dynamics in stacked 2D materials, leading to next-generation broadband silicon-based image sensors.
“TRIPLET APPROACH”- COMBINATION OF ORTHOPEDIC, MYOFUNCTIONAL AND FIXED MECHANOTHERAPY
Authors: Manish  Goyal  , Mukesh Kumar  , Sumit Kumar  , Shalini Mishra  
Published: November 2020

Abstract-
A 13 year old female patient came to our department with chief complain of excessive gum show. On Clinical examination patient presented with convex facial profile, obtuse nasolabial angle, mesocephalic, mesoprosopic, incompetent lips and increased interlabial gap. Intraorally she had class II canine and molar relation bilaterally with crowding irt 31, 32, 33, 41, 42, 43. Patient was really concerned about her facial profile. So we decided to manage the same with triplet approach i.e the combination of orthopedic, myofunctional and fixed mechanotherapy. The total treatment time was 28 months which include 13 month phase I therapy and 15 months phase II therapy and the results were exuberant.
ISOLAMENTO SOCIAL, MOMENTO DE BRINCAR COM ANITA
Authors: Queiroz Maria lícia Silva de , Fontes Tereza Genoveva Nascimento Torezani , Silva Maely de Souza da , Santos Clara Campos dos , Sousa Sarah Silva 
Published: November 2020

No contexto que vivemos chegar ao final da pandemia e saber que a ação desenvolvida, “Brincando com Anita”, possibilitou uma melhora na qualidade do cotidiano, tão diferente, e criou momentos de brincadeiras, alegrias e fantasias, esse é o resultado esperado da ação que foi criada especificamente para o período de Isolamento Social. Uma ação que faz parte do projeto de extensão “Cidade Imaginada... Cidade Possível”. O blog da ação contém sugestões de brincadeiras, desafios, vídeos e uma série de histórias, algumas inéditas, adaptadas para o cenário do isolamento social.
Palavras-chave: Isolamento Social; Entretenimento; Cotidiano Infanto-juvenil.
Distinct Forms of Spinal Cysticercosis: A Vietnamese Case Series
Authors: Hung Nguyen D. , Duc Nguyen M. , Sy Than V. , Dung Le T. , Tuan Trinh A. , Hue Nguyen D. 
Published: November 2020

Introduction:
Neurocysticercosis (NCC), a major contributor to the burden of seizure disorders
and epilepsy in the world, is one of the most common parasitic infections of the central nervous
system, which is usually located in the brain. Medical therapy for NCC should initially cover
appropriate symptom control and then the use of antiparasitic agents should be considered. Antiparasitic
treatment is of benefit in most cases of viable and degenerating NCC. Nevertheless, cysticercosis
of the spinal cord is very uncommon.

Case series:
In this article, we recorded 5 cases of extramedullary-intradural lumbar spinal cysticercosis, in which one
case displayed cystic lesions in both brain and spine, one case showed an independent cystic lesion in the spine, and three
remaining cases showed diffuse lesions in the spinal canal.

Conclusion:
Thus, in any case of single or numerous cystic lesions or dispersed lesions entering
the spinal canal, spinal cysticercosis should be considered.