bluuebunny/crossref_metadata_2025_split huggingface dataset:
IntuitivePlan inverse planning performance evaluation for Gamma Knife radiosurgery of AVMs
Authors: Paddick Ian , Grishchuk Diana , Dimitriadis Alexis 
Published: August 2020

AbstractPurposeTo compare planning indices achieved using manual and inverse planning approaches for Gamma Knife radiosurgery of arterio‐venous malformations (AVMs).Methods and materialsFor a series of consecutive AVM patients, treatment plans were manually created by expert planners using Leksell GammaPlan (LGP). Patients were re‐planned using a new commercially released inverse planning system, IntuitivePlan. Plan quality metrics were calculated for both groups of plans and compared.ResultsOverall, IntuitivePlan created treatment plans of similar quality to expert planners. For some plan quality metrics statistically significant higher scores were achieved for the inversely generated plans (Coverage 96.8% vs 96.3%, P = 0.027; PCI 0.855 vs 0.824, P = 0.042), but others did not show statistically significant differences (Selectivity 0.884 vs 0.856, P = 0.071; GI 2.85 vs 2.76, P = 0.096; Efficiency Index 47.0% vs 48.1%, P = 0.242; Normal Brain V12(cc) 5.81 vs 5.79, P = 0.497). Automatic inverse planning demonstrated significantly shorter planning times over manual planning (3.79 vs 11.58 min, P < 10−6) and greater numbers of isocentres (40.4 vs 10.8, P < 10−6), with an associated cost of longer treatment times (57.97 vs 49.52 min, P = 0.009). When planning and treatment time were combined, there was no significant difference in the overall time between the two methods (61.76 vs 61.10, P = 0.433).ConclusionsIntuitivePlan can offer savings on the labor of treatment planning. In many cases, it achieves higher quality indices than those achieved by an “expert planner”.
Risk of Incident Type 2 Diabetes Mellitus Among Patients With Rheumatoid Arthritis: A Population‐Based Cohort Study
Authors: Jin Yinzhu , Chen Sarah K. , Liu Jun , Kim Seoyoung C. 
Published: August 2020

ObjectiveTo examine the risk of incident type 2 diabetes mellitus (DM) among patients with rheumatoid arthritis (RA) versus the risk among 4 different comparison cohorts.MethodsUsing a large US commercial insurance database, Optum Clinformatics Data Mart (2005–2017), we identified patients with RA based on ≥2 diagnoses for RA and use of ≥1 disease‐modifying antirheumatic drug. We selected 4 comparison cohorts with ≥2 disease‐specific diagnoses and ≥1 dispensing of disease‐specific drugs: 1) general non‐RA patients, 2) patients with hypertension, 3) patients with osteoarthritis (OA), and 4) patients with psoriatic arthritis (PsA). The index date was the disease‐specific drug dispensing date. Patients with RA were matched to the comparator cohorts (except PsA) for age as of the index date, sex, and index date. The primary outcome was incident type 2 DM, defined as a new diagnosis of type 2 DM plus a new dispensing of antidiabetic drugs. A multivariable Cox proportional hazards model estimated hazard ratios of incident type 2 DM among RA versus each of the comparison cohorts, accounting for >40 baseline covariates.ResultsA total of 449,327 RA, general non‐RA, hypertension, OA, or PsA patients were selected. During the median of 1.6 (range 0.6–3.3) years of follow‐up, the incidence rate of type 2 DM was the lowest in the RA cohort (7.0 per 1,000 person‐years) and highest (12.3 per 1,000 person‐years) in the hypertension cohort. After adjusting for >40 baseline covariates, we found that RA was associated with a 24–35% lower risk of incident type 2 DM compared to 4 comparison groups.ConclusionIn this large population‐based cohort study, patients with RA had a lower rate of incident type 2 DM compared to the general non‐RA, hypertension, OA, and PsA cohorts.
Interval functional observers for time‐delay systems with additive disturbances
Authors: Cong Huong Dinh , Thanh Huynh Van , Trinh Hieu 
Published: August 2020

SummaryThis article considers the design of interval functional observers to estimate a linear function of the state vector of time‐delay systems subject to both input and output additive disturbances. Two novel functional observers are proposed and designed such that they bound the set of all admissible values of a linear function of the state vector at each instant of time. By contrast to interval observers currently available in the literature, both observers proposed in this article utilize multiple delayed output measurement and have a more general structure. This trade‐off feature overcomes some drawbacks in previous work and enables interval functional observers to be designed for a wider class of time‐delay systems. Conditions for the existence of interval functional observers are derived and an effective design algorithm for computing unknown observer matrices is provided. Two illustrative examples are given to show the advantages and effectiveness of our design method.
Sequence‐Defined Peptoids with OH and COOH Groups As Binders to Reduce Cracks of Si Nanoparticles of Lithium‐Ion Batteries
Authors: Zhang Qianyu , Zhang Chaofeng , Luo Wenwei , Cui Lifeng , Wang Yan‐Jie , Jian Tengyue , Li Xiaolin , Yan Qizhang , Liu Haodong , Ouyang Chuying , Chen Yulin , Chen Chun‐Long , Zhang Jiujun 
Published: August 2020

AbstractSilicone (Si) is one type of anode materials with intriguingly high theoretical capacity. However, the severe volume change associated with the repeated lithiation and delithiation processes hampers the mechanical/electrical integrity of Si anodes and hence reduces the battery's cycle‐life. To address this issue, sequence‐defined peptoids are designed and fabricated with two tailored functional groups, “OH” and “COOH”, as cross‐linkable polymeric binders for Si anodes of LIBs. Experimental results show that both the capacity and stability of such peptoids‐bound Si anodes can be significantly improved due to the decreased cracks of Si nanoparticles. Particularly, the 15‐mer peptoid binder in Si anode can result in a much higher reversible capacity (ca. 3110 mAh g−1) after 500 cycles at 1.0 A g−1 compared to other reported binders in literature. According to the density functional theory (DFT) calculations, it is the functional groups presented on the side chains of peptoids that facilitate the formation of Si−O binding efficiency and robustness, and then maintain the integrity of the Si anode. The sequence‐designed polymers can act as a new platform for understanding the interactions between binders and Si anode materials, and promote the realization of high‐performance batteries.
Nanoparticles (NPs)‐Meditated LncRNA AFAP1‐AS1 Silencing to Block Wnt/β‐Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy
Authors: Bi Zhuofei , Li Qingjian , Dinglin Xiaoxiao , Xu Ying , You Kaiyun , Hong Huangming , Hu Qian , Zhang Wei , Li Chenchen , Tan Yujie , Xie Ning , Ren Wei , Li Chuping , Liu Yimin , Hu Hai , Xu Xiaoding , Yao Herui 
Published: August 2020

AbstractResistance to radiotherapy is frequently encountered in clinic, leading to poor prognosis of cancer patients. Long noncoding RNAs (lncRNAs) play important roles in the development of radioresistance due to their functions in regulating the expression of target genes at both transcriptional and posttranscriptional levels. Exploring key lncRNAs and elucidating the mechanisms contributing to radioresistance are crucial for the development of effective strategies to reverse radioresistance, which however remains challenging. Here, actin filament‐associated protein 1 antisense RNA1 (lncAFAP1‐AS1) is identified as a key factor in inducing radioresistance of triple‐negative breast cancer (TNBC) via activating the Wnt/β‐catenin signaling pathway. Considering the generation of a high concentration of reduction agent glutathione (GSH) under radiation, a reduction‐responsive nanoparticle (NP) platform is engineered for effective lncAFAP1‐AS1 siRNA (siAFAP1‐AS1) delivery. Systemic delivery of siAFAP1‐AS1 with the reduction‐responsive NPs can synergistically reverse radioresistance by silencing lncAFAP1‐AS1 expression and scavenging intracellular GSH, leading to a dramatically enhanced radiotherapy effect in both xenograft and metastatic TNBC tumor models. The findings indicate that lncAFAP1‐AS1 can be used to predict the outcome of TNBC radiotherapy and combination of systemic siAFAP1‐AS1 delivery with radiotherapy can be applied for the treatment of recurrent TNBC patients.
Excite Spoof Surface Plasmons with Tailored Wavefronts Using High‐Efficiency Terahertz Metasurfaces
Authors: Wang Zhuo , Li Shiqing , Zhang Xueqian , Feng Xi , Wang Qingwei , Han Jiaguang , He Qiong , Zhang Weili , Sun Shulin , Zhou Lei 
Published: August 2020

AbstractSpoof surface plasmons (SSPs) play crucial roles in terahertz (THz) near‐field photonics. However, both high‐efficiency excitation and wavefront engineering of SSPs remain great challenges, which hinder their wide applications in practice. Here, a scheme is proposed to simultaneously achieve these two goals efficiently using a single ultracompact device. First, it is shown that a gradient meta‐coupler constructed by high‐efficiency Pancharatnam–Berry (PB) meta‐atoms can convert circularly polarized (CP) THz beams into SSPs with absolute efficiency up to 60%. Encoding a parabolic phase profile into the meta‐coupler based on the PB mechanism, it is demonstrated that the device can covert CP beams into SSPs with focusing or defocusing wavefronts, dictated by the chirality of the incident wave. Finally, two distinct chirality‐dependent phase distributions are encoded into the meta‐coupler design by combining the PB and resonance phase mechanisms, and it is demonstrated that the resulting meta‐device can achieve SSP excitations with chirality‐delinked bifunctional wavefront engineering. THz near‐field experiments are performed to characterize all three devices, in excellent agreement with full‐wave simulations. The results pave the road to realize ultracompact devices integrating different functionalities on near‐field manipulations, which can find many applications (e.g., optical sensing, imaging, on‐chip photonics, etc.) in different frequency domains.
SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity
Authors: Li Miao , Wang Hongwu , Liao Hongwei , Shen Jiaxin , Wu Yinfang , Wu Yanping , Weng Qingyu , Zhu Chen , Geng Xinwei , Lan Fen , Xia Yang , Zhang Bin , Zou Hang , Zhang Nan , Zhou Yunzhi , Chen Zhihua , Shen Huahao , Ying Songmin , Li Wen 
Published: August 2020

AbstractHigh‐throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers. However, the heritability of a substantial proportion of cancers remains unexplained, which may result from rare deleterious mutations hidden in a myriad of nonsense genetic variations. This poses a great challenge to the understanding of the pathology and thus the rational design of effective treatments for affected patients. Here, whole genome sequencing is employed in a representative case in which one monozygotic twin is discordant for lung inflammatory myofibroblastoma to disclose rare tumor‐related mutations. A missense single nucleotide variation rs61955126 T>C in the lysine methyltransferase SETD8 (accession: NM_020382, SETD8C302R) is exposed. It is shown that SETD8 is vital for genomic integrity by promoting faithful DNA replication, and its C302R mutation downregulates the p53/p21 pathway. Importantly, the SETD8C302R mutation significantly increases the sensitivity of cancer cells to WEE1 inhibition. Given that WEE1 inhibitors have shown great promise for clinical approval, these results impart a potential therapeutic approach using WEE1 inhibitor for cancer patients carrying the same mutation, and indicate that genome sequencing and genetic functional studies can be integrated into individualized therapies.
Temporal biological nitrogen fixation pattern in soybean inoculated with Bradyrhizobium
Authors: Pitumpe Arachchige Pavithra S. , Rosso Luiz H. Moro , Hansel Fernando D. , Ramundo Bruce , Torres Adalgisa R. , Asebedo Ray , Ciampitti Ignacio A. , Jagadish S.V. Krishna 
Published: August 2020

AbstractBiological nitrogen fixation (BNF) in soybean [Glycine max (L.) Merr.] plays an important role in sustainable agriculture, reducing the limitations associated with other sources of N such as fertilizers and soils. Our major objective was to evaluate the weekly pattern of BNF in soybean influenced by nodule formation, using three different laboratory‐cultured Bradyrhizobium strains. Plants were grown in 1‐m polyvinyl chloride (PVC) columns for 17 week in a greenhouse and BNF was determined using an integrated approach by assessing nodule formation, stem ureide‐N, and N partitioning in plant parts. Bradyrhizobium strains showed overall similar plant performance and N2−fixation capacity. During the beginning of flowering/full bloom (R1/R2) growth stages, nodule formation significantly increased and reached a maximum at pod‐filling (R4) stage. Stem ureide‐N was detected at early growth stages even with fewer small nodules, which significantly increased after the beginning of pod formation (R3). Peak N2−fixing rate (g N kg−1 d−1) started to decline after the onset of seed filling (R5.5). Relationship between BNF and nodule parameters (nodule number [R2 = .65] and nodule weight [R2 = .62]) suggested that they can be used as predictors of BNF.
Plasmon‐induced photothermal effect of sub‐10‐nm Cu nanoparticles enables boosted full‐spectrum solar H2 production
Authors: Song Rui , Liu Maochang , Luo Bing , Geng Jiafeng , Jing Dengwei 
Published: August 2020

AbstractDistinguishing the contributions from localized surface plasmon resonance (LSPR)induced photothermal effect is a significant challenge in the study of solar hydrogen production. Herein, a well‐defined one‐dimensional Cu/TiO2 heterostructure with Cu size of 3–6 nm is designed to address such issue. Cu nanoparticles present notable LSPR absorption from visible to near‐infrared light, while no hydrogen is produced in the presence of simulated light with λ ≥ 700 nm. Interestingly, a remarkable improvement of hydrogen evolution under full‐spectrum light was observed which is almost twice of that under only ultraviolet–visible light irradiation, implying the critical yet auxiliary role of LSPR‐induced photothermal effect in promoting photocatalytic performance. Significantly, a notable reduction of the apparent activation energy and strengthened charge separation efficiency are observed due to the increased local temperature of catalyst surface caused by the plasmon‐induced photothermal effect. The kinetic and thermodynamic changes should be responsible for the enhanced hydrogen production.
Influence of particle size and glassy carbon content on the thermal, mechanical, and electrical properties ofPHBV/glassy carbon composites
Authors: de Souza Vieira Leonardo , Montagna Larissa Stieven , Marini Juliano , Passador Fabio Roberto 
Published: August 2020

AbstractGlassy carbon (GC) constitutes a promising carbonaceous material that can be employed as an antistatic agent in the development of antistatic packaging used in the electronics industry. Thus, the present work aims at developing biodegradable and antistatic packaging from poly(hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) reinforced with different GC contents (0, 0.5, 1.0, 2.5, and 5.0 wt%) and different GC particle size (<45 μm and > 75 μm) using extrusion processing. differential scanning calorimetry analysis shows that the addition of GC decreases the degree of crystallinity (Xc) of PHBV, which can explain the reduction of its stiffness. Impedance spectroscopy results reveal that the use of GC contents greater than 2.5 wt% (GC > 75 μm) makes possible the obtainment of a material with an electrical resistivity small enough to be used in antistatic packaging. It can be concluded that GC is an interesting alternative of antistatic agent for electrically dissipative packaging.
Multi‐Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility
Authors: Parker Eleanor , Hofer Ines M. J. , Rice Sarah J. , Earl Lucy , Anjum Sami A. , Deehan David J. , Loughlin John 
Published: August 2020

ObjectiveOsteoarthritis (OA) is polygenic, with more than 90 risk loci currently mapped, including at the single‐nucleotide polymorphism rs6516886. Previous analysis of OA cartilage DNA identified 6 CpG dinucleotides whose methylation levels correlated with the rs6516886 genotype, forming methylation quantitative trait loci (mQTLs). We undertook this study to investigate these mQTLs and to map expression quantitative trait loci (eQTLs) across joint tissues in order to prioritize a particular gene as a target of the rs6516886 association effect.MethodsNucleic acids were extracted from the cartilage, fat pad, synovium, and peripheral blood from OA patients. Methylation of CpGs and allelic expression imbalance of potential target genes were assessed by pyrosequencing. A chondrocyte cell line expressing deactivated Cas9 (dCas9)–TET1 was used to directly alter CpG methylation levels, with effects on gene expression quantified by polymerase chain reaction.ResultsMultiple mQTLs were detected, with effects strongest in joint tissues and with methylation at CpG cg20220242 correlating most significantly with the rs6516886 genotype. CpG cg20220242 is located upstream of RWDD2B. Significant rs6516886 eQTLs were observed for this gene, with the OA risk–conferring allele of rs6516886 correlating with reduced expression CpG methylation also correlated with allelic expression of RWDD2B, forming methylation–expression QTLs (meQTLs). Deactivated Cas9–TET1 reduction in the methylation of cg20220242 increased expression of RWDD2B.ConclusionThe rs6516886 association signal is a multi‐tissue meQTL involving cg20220242 and acting on RWDD2B. Modulating CpG methylation reverses the impact of the risk allele. RWDD2B codes for a protein about which little is currently known. Its further analysis as a target of OA genetic risk will provide novel insight into this complex disease.
Single‐fraction image‐guided robotic radiosurgery efficiently controls local prostate cancer recurrence after radical prostatectomy
Authors: Spek A. , Graser A. , Habl G. , Muacevic A. , Fuerweger C. , Seitz M. , Haidenberger A. 
Published: August 2020

AbstractPurposeTo assess the therapeutic potential of single‐fraction robotic stereotactic ablative body radiotherapy (SABR) in patients with locally recurrent prostate cancer (PC) after radical prostatectomy (RP).Materials and methodsWe included 35 patients with biochemical failure after RP with single‐site local recurrence in the prostate bed diagnosed by PSMA PET/CT. About 20/35 pts had previously received post‐surgical adjuvant radiation therapy.High‐resolution multiparametric magnetic resonance imaging (mpMRI) for exact visualization of tumor tissue was performed at 1.5 (n = 23; Siemens Magnetom Aera) or 3 Tesla (n = 12; Siemens Magnetom VIDA, Siemens Healthineers, Erlangen, Germany). Using the MRI and PET/CT dataset for planning, SABR was carried out after ultrasound‐guided placement of a single gold fiducial marker at the site of tumor recurrence using a CyberKnife M6 unit (Accuray Inc., Sunnyvale, USA). Due to the high diagnostic accuracy of PSMA PET/CT and mpMRI, pre‐SABR biopsy of tumor tissue was not deemed necessary. PSMA PET/CT performed in median 88 days before SABR confirmed the absence of distant metastases. MpMRI was performed at a median of 22 days prior to the intervention. SABR was performed in a single fraction with a dose of 20 (5/35), 21 (27/35) or 22 (3/35) Gy. Follow‐up serum PSA was measured every 3 months thereafter.ResultsMedian patient age was 72 years (57‐80 years) and median time from RP to SABR was 96.8 months (IQR, 69.3‐160.2). Median serum PSA before SABR was 1.38 ng/mL (IQR 0.75‐2.72). At 3 months, median PSA had dropped significantly in 27/35 patients to a median of 0.35 ng/mL (IQR 0.25‐0.68). At 6 months, 30/35 patients showed biochemical response to SABR, while five patients were progressing: three had systemic disease on PSMA PET/CT, while two patients had rising PSA values without a visible correlate on PET/CT. The median follow‐up time was 16 months. Grade 1 genitourinary (GU) toxicity was reported in 3/35 patients (9%) and grade 1 gastrointestinal (GI) toxicity in 2/35 patients (6%), respectively.ConclusionSABR is an efficient new treatment option in the management of single‐site local recurrent PC without the evidence of systemic disease; due to its very low toxicity, it is an alternative to surgical re‐treatment or other focal therapies. It can significantly delay the onset of androgen deprivation therapy (ADT) in biochemical failure after radical prostatectomy.
Effects of stakeholder pressure, managerial perceptions, and resource availability on sustainable operations adoption
Authors: Jiao Jinxia , Liu ChenGuang , Xu Yan 
Published: August 2020

AbstractThis study aims to examine how stakeholder pressure, managerial perceptions, and resource availability influence the adoption of sustainable operations (SO) in Chinese manufacturing firms. A conceptual model is proposed on the basis of relevant literature and tested using structural equation model (SEM) with data from 217 Chinese manufacturing firms. The results show that stakeholder pressure is grouped into three categories: governmental pressure, primary stakeholder pressure, and secondary stakeholder pressure. Among the three kinds of stakeholder pressure, only primary stakeholder pressure can significantly affect SO adoption. Moreover, the results reveal that managerial perceptions of SO and resource availability significantly influence the adoption of SO. Additionally, the results indicate that the relationship between resource availability and SO adoption is partially mediated by managerial perceptions of SO and that the relationship between primary stakeholder pressure and SO adoption is fully mediated by managerial perceptions of SO. This study provides some implications for both policy makers and firm managers and meanwhile suggests limitations and opportunities for future research.