bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of a femoral pseudoaneurysm by ultrasonographically‐guided application of a suture‐mediated closure device
Authors: Gong Xue , Zhang Wenlong , Sang Lin , Sun Yuanyuan , Yu Ming 
Published: September 2020

AbstractWe treated successfully a man with a femoral artery pseudoaneurysm by ultrasonography‐guided application of a suture‐mediated closure device. Radiography was not needed, as a guide wire was placed into the femoral artery along the rupture under ultrasonographic guidance alone, and the femoral artery was then sutured with the vascular closure device. The pseudoaneurysm was then completely resolved. This novel approach, which minimizes risks and costs, may be a safe and acceptable option to control iatrogenic pseudoaneurysms, especially when thrombin injection is not feasible.
Patient satisfaction with dental treatment at a university dental clinic: A qualitative analysis
Authors: Klaassen Hannah , Dukes Kimberly , Marchini Leonardo 
Published: September 2020

AbstractPurpose/ObjectivesThe aim for this study was to identify important factors influencing patient satisfaction in a university dental clinic, through qualitative analysis.MethodsFrom June 1, 2014 to January 30, 2018, 7827 patient satisfaction surveys were collected. A thematic analysis was conducted on the 10,956 patient responses to 3 open‐ended questions. A thematic coding dictionary was inductively developed using thematic analysis managed with MAXQDA 2018 Standard, a qualitative data management software program.ResultsThe thematic dictionary included 12 categories, developed from 48 working codes, and enabled the patient annotations to be grouped and sorted based on common themes to highlight significant aspects of the patient experience. Four notable themes that emerged from patient comments include: (1) satisfaction with the emotional care felt during their appointments; (2) satisfaction with skills and treatment provided and the connections made with various personnel; (3) the importance of establishing and maintaining patient expectations throughout their care; and (4) the high value patients place on clear communication with the patient, as well as the communication between departments, dental student and faculty, providers, and front desk.ConclusionThe results of this study highlight 12 key themes related to the patient experience at the College of Dentistry from the patients’ perspective. These data provide insight into aspects of the dental experience that have a large effect on patient satisfaction. With this knowledge, steps can be taken to enhance the patient experience and, therefore, help dental schools move further in the direction of person‐centered care.
New‐onset posttransplant diabetes mellitus after haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide
Authors: Mangan Brendan L. , Patel Dilan , Chen Heidi , Gatwood Katie S. , Byrne Michael T. , Sengsayadeth Salyka , Goodman Stacey , Dholaria Bhagirathbhai , Kassim Adetola A. , Jagasia Madan , Chinratanalab Wichai , Culos Kathryn A. , Engelhardt Brian G. 
Published: September 2020

AbstractHaploidentical hematopoietic cell transplantation (haplo‐HCT) with posttransplant cyclophosphamide (PTCY) is utilized for patients with hematological disorders but without conventional donors. The effects of new‐onset posttransplant diabetes mellitus (PTDM) following haplo‐HCT are unknown. We examined PTDM incidence and outcomes after haplo‐HCT with PTCY. Patients without diabetes receiving haplo‐HCT (n = 64) were analyzed for PTDM diagnosis (defined as blood glucose ≥ 200 mg/dL). By day 100, 14 (22%) patients developed PTDM (median, 18 days). Hyperglycemia (blood glucose ≥ 200 mg/dL) preceded corticosteroids in 11 (79%) individuals. PTDM patients had increased death/relapse (P = .029). PTDM occurs frequently, precedes corticosteroids, and leads to inferior outcomes following haplo‐HCT. PTDM prophylaxis/treatment may improve HCT survival.
Comparative morphology of shark pectoral fins
Authors: Hoffmann Sarah L. , Buser Thaddaeus J. , Porter Marianne E. 
Published: September 2020

AbstractSharks vary greatly in morphology, physiology, and ecology. Differences in whole body shape, swimming style, and physiological parameters have previously been linked to varied habitat uses. Pectoral fin morphology has been used to taxonomically classify species and hypotheses on the functional differences in shape are noted throughout the literature; however, there are limited comparative datasets that quantify external and skeletal morphology. Further, fins were previously categorized into two discrete groups based on the amount of skeletal support present: (a) aplesodic, where less than half of the fin is supported and (b) plesodic where greater than half of the fin is supported. These discrete classifications have been used to phylogenetically place species, though the methodology of classification is infrequently described. In this study, we sampled fins from 18 species, 6 families, and 3 orders, which were also grouped into five ecomorphotype classifications. We examined the external morphology, extent of skeletal support, and cross‐sectional shape of individual cartilaginous elements. Using phylogenetic comparative methods, we show that fin shape does not differ significantly between ecomorphotypes, suggesting there may be some mechanical constraint. However, we find that the internal anatomy of the fin does vary significantly between ecomorphotypes, especially the extent and distribution of calcification of skeletal support, suggesting that the superficial similarity of fin shapes across ecomorphotypes may belie differences in function. Finally, we find that a number of morphological variables such as number of radials, radial calcification and shape, and fin taper all correlate with the extent of skeletal support. Within these morphospaces, we also describe that some orders/families tend to occupy certain areas with limited overlap. While we demonstrate that there is some mechanical constraint limiting external variations in shark pectoral fin morphology, there are compounding differences in skeletal anatomy that occur within ecomorphotypes which we propose may affect function.
Convalescent plasma for the treatment of patients with severe coronavirus disease 2019: A preliminary report
Authors: Omrani Ali S. , Zaqout Ahmed , Baiou Anas , Daghfal Joanne , Elkum Naser , Alattar Rand A. , Bakdach Dana , Abusriwil Hatem , Mostafa Abdalrahman M. , Alhariri Bassem , Ambra Naseem , Khatib Mohamed , Eldeeb Ali M. , Merenkov Zeyd , Fawzi Zeinab , Hmissi Saloua M. , Hssain Ali A. , Coyle Peter V. , Alsoub Hussam , Almaslamani Muna A. , Alkhal Abdullatif 
Published: September 2020

AbstractBackgroundThe role of convalescent plasma therapy for patients with coronavirus disease 2019 (COVID‐19) is unclear.MethodsWe retrospectively compared outcomes in a cohort of critical COVID‐19 patients who received standard care (SC Group) and those who, in addition, received convalescent plasma (CP Group).ResultsIn total, 40 patients were included in each group. The median patient age was 53.5 years (interquartile range [IQR] 42–60.5), and the majority of patients required invasive ventilation (69, 86.2%). Plasma was harvested from donors after a median of 37 days (IQR 31–46) from the first positive severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) polymerase chain reaction (PCR) result and 26 days (IQR 21–32) after documented viral clearance; it was administered after a median of 10 days (IQR 9–10) from the onset of symptoms and 2.5 days (IQR 2–4) from admission to intensive care unit. The primary endpoint of improvement in respiratory support status within 28 days was achieved in 26 patients (65%) in the SC Group and 31 patients (77.5%) in the CP Group (p = .32). The 28‐day all‐cause mortality (12.5% vs. 2.5%; p = .22) and viral clearance (65% vs. 55%; p = .49) were not significantly different between the two groups. Convalescent plasma was not significantly associated with the primary endpoint (adjusted hazard ratio 0.87; 95% confidence interval 0.51–1.49; p = .62). Adverse events were balanced between the two study groups.ConclusionIn severe COVID‐19, convalescent plasma therapy was not associated with clinical benefits. Randomized trials are required to confirm our findings.
Could ferritin level be an indicator of COVID‐19 disease mortality?
Authors: Tural Onur Seda , Altın Sedat , Sokucu Sinem Nedime , Fikri Burcu İleri , Barça Tuğçe , Bolat Erkut , Toptaş Mehmet 
Published: September 2020

AbstractWhile the number of coronavirus disease‐2019 (COVID‐19) cases is increasing day by day, there is limited information known about the hematological and laboratory findings of the disease. We aimed to investigate whether serum ferritin level predicts mortality is a marker for rapid progression for inpatients. Our study included 56 patients who were died due to COVID‐19 as the study group, and 245 patients who were hospitalized and recovered as the control group. The laboratory data of the patients were evaluated from the first blood tests (pre) taken from the first moment of admission to the hospital and the blood tests taken from before the patient's discharge or exitus (post) were evaluated retrospectively. The mean age of the nonsurvivor group was 62.0 ± 15.7 and the mean age of the control group was 54.34 ± 13.03. Age and length of stay are significantly higher in the nonsurvivor group. When comparing the pre‐ and postvalues of ferritin, according to the two groups separately, there was no significant difference in the control group and a high level of significance was observed in the nonsurvivor group (p < .01). COVID‐19 disease caused by severe acute respiratory syndrome coronavirus‐2 causes high mortality with widespread inflammation and cytokine storm. Ferritin is a cheap and widespread available marker, ferritin, which can be used for its predictivity of the mortality and hope it would be a useful marker for clinicians for the management of the disease.
Severe fever with thrombocytopenia syndrome in Hefei: Clinical features, risk factors, and ribavirin therapeutic efficacy
Authors: Zhang Yin , Miao Wen , Xu Yuanhong , Huang Ying 
Published: September 2020

AbstractObjectivesThis study described the clinical features, risk factors, factors affecting the outcome of this disease, and ribavirin therapeutic efficacy for severe fever with thrombocytopenia syndrome (SFTS) patients in Hefei.MethodsBetween April 2020 and July 2020, 62 cases admitted to the First Affiliated Hospital of Anhui Medical University were included in this study. Serum samples were collected from all patients, after which diagnosis was made via reverse transcription‐polymerase chain reaction and via the use of a colloidal gold immunochromatography assay approach.ResultsIn multivariate analysis, the following factors were determined as risk factors for SFTS: Being a farmer (odds ratio [OR], 3.033), working in areas with weeds and shrubs (OR, 2.807), and being bitten by a tick (OR, 6.64). The rates of confusion, neck stiffness, viral encephalopathy, and the presence of liver damage were higher in the patients who died than that in the surviving ones. Additionally, the median of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine phosphokinase, activated partial thromboplastin time, D‐dimer, fibrinogen degradation products, creatinine, and urea was also higher in the patients who died. One of the 15 patients treated with ribavirin in the early stage could not survive (6.7%), whereas 11 of the 35 patients treated with ribavirin in the late stage could not survive (31.4%); this difference was statistically significant. However, there was no significant difference in mortality between the untreated group and the other two groups (i.e., patients who started antiviral treatment <5 days from the onset and those who started antiviral treatment ≥5 days from the onset). Moreover, there was no positive effect determined on clinical or laboratory parameters in SFTS patients treated with ribavirin. Also, it was observed that leukocyte levels and platelet levels took longer to return to normal.ConclusionsIn Hefei, clinical features, prognostic factors, and risk factors associated with SFTS are similar to those in other areas. Patients who were given ribavirin did not have better survival rates than patients who were not given ribavirin.
A hybridizable discontinuous Galerkin method for simulation of electrostatic problems with floating potential conductors
Authors: Chen Liang , Dong Ming , Li Ping , Bagci Hakan 
Published: September 2020

AbstractIn an electrostatic simulation, an equipotential condition with an undefined/floating potential value has to be enforced on the surface of an isolated conductor. If this conductor is charged, a nonzero charge condition is also required. While implementation of these conditions using a traditional finite element method (FEM) is not straightforward, they can be easily discretized and incorporated within a discontinuous Galerkin (DG) method. However, DG discretization results in a larger number of unknowns as compared to FEM. In this work, a hybridizable DG (HDG) method is proposed to alleviate this problem. Floating potential boundary conditions, possibly with different charge values, are introduced on surfaces of each isolated conductor and are weakly enforced in the global problem of HDG. The unknowns of the global HDG problem are those only associated with the nodes on the mesh skeleton and their number is much smaller than the total number of unknowns required by DG. Numerical examples show that the proposed method is as accurate as DG while it improves the computational efficiency significantly.
On integrability of an extended Bogoyavlenskii‐Kadomtsev‐Petviashvili equation: Multiple soliton solutions
Authors: Wazwaz Abdul‐Majid 
Published: September 2020

AbstractIn this paper, we construct an extended Bogoyavlenskii‐Kadomtsev‐Petviashvili (eBKP) equation. We use the Painlevé analysis to justify the integrability of the eBKP equation. We also examine the integrability of a related extended CBS equation. We derive multiple soliton solutions via using the Hirota's direct method. In addition, a variety of exact solutions, that include singular kink solutions, periodic solutions, and exponential solutions, are derived as well.
Combined pedicled superficial circumflex iliac artery perforator (SCIP) flap with lymphatic tissue preservation and lymphovenous anastomosis (LVA) for defect reconstruction and lymphedema–lymphocele prevention in thigh sarcoma surgery: Preliminary results
Authors: Scaglioni Mario F. , Meroni Matteo , Fritsche Elmar , Fuchs Bruno 
Published: September 2020

AbstractBackgroundSarcoma surgery often requires large tissue resection to be treated safely. When the tumor is localized in the groin and/or medial thigh, lymphocele and lymphedema are common complications because of the rich lymphatic network present there. The aim of this study is to share the outcome of seven patients who received defect reconstruction in this area with combined pedicled superficial circumflex artery perforator (SCIP) flap with lymphatic tissue preservation and lymphovenous anastomosis (LVA) for prevention of lymphatic complications.Patients and MethodsSeven patients who underwent surgical resection of sarcoma in the groin and/or adductors compartment received defect reconstruction with pedicled SCIP flap combined with LVA. For a better dead space obliteration, four of them also received an additional tissue flap: two pedicled deep inferior epigastric perforator flaps and two free anterolateral thigh flaps. Indocyanine green lymphography was performed in all cases to identify the lymphatic pathway, make the preoperative marking and check the patency of the anastomoses.ResultsAll seven patients were successfully treated reaching a good aesthetic result and a full range of motion. No immediate nor delayed complications such as lymphocele or lymphorrhea and early extremity lymphedema were observed during the follow up (range: 6–9 months; mean: 7.3) and no secondary procedures were required.ConclusionsThe combination of the pedicle SCIP lymphatic tissue transfer with LVA seems to be effective in preventing the development of lymphatic sequelae after large resections in the medial thigh.
Versatile Polarization Generation and Manipulation Using Dielectric Metasurfaces
Authors: Ding Fei , Chang Bingdong , Wei Qunshuo , Huang Lingling , Guan Xiaowei , Bozhevolnyi Sergey I. 
Published: September 2020

AbstractAdvances in polarization optics and integrated photonics require fundamentally new polarization‐managing strategies allowing for efficient generation and complete control over vectorial fields with well‐defined polarization states using surface‐confined configurations with ultracompact footprints and extended bandwidths. Recently, metasurfaces have been extensively explored to demonstrate compact planar devices enabling diverse polarization control. However, the main drawback of the state‐of‐the‐art metasurface‐based polarization converters is related to their limitations resulting in individual simple functionalities and low‐efficiencies. Here, the strategy for producing dielectric metasurfaces that efficiently generate diversified polarization states with controllable wavefronts and high efficiencies over a broadband spectrum range from a linearly‐polarized light source by generalizing an existing theory of simultaneous phase and polarization control with birefringent meta‐atoms, is demonstrated. Advanced polarization and wavefront manipulation functionalized to realize an efficient polarization‐resolved multifocal metalens and vectorial holographic display is accomplished using judiciously designed dielectric metasurfaces composed of segmented sub‐arrays capable of manipulating, simultaneously and independently, both polarization and phase of the transmitted beams. The versatility of this concept provides opportunities to develop a complete set of flat polarization optics for integrated photonics and quantum optics.
Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma
Authors: Wenande Emily , Hendel Kristoffer , Mogensen Mette , Bagger Charlotte , Mårtensson Nina L. , Persson Daniel P. , Lerche Catharina M. , Husted Søren , Janfelt Christian , Togsverd‐Bo Katrine , Anderson Richard R. , Haedersdal Merete 
Published: September 2020

Background and ObjectivesRising incidences of basal cell carcinoma (BCC) have increased the need for effective topical therapies. By enhancing cutaneous uptake of the chemotherapeutic agents, cisplatin and 5‐fluorouracil (5‐FU), laser‐assisted delivery may provide a new combination treatment for BCC. Accordingly, this study aimed to evaluate tumor response, safety, and drug biodistribution in tumors and blood after topical laser‐assisted 5‐FU + CIS treatment in BCC patients.Study Design/Materials and MethodsThis open‐label, proof‐of‐concept trial investigated laser‐assisted combination cisplatin + 5‐FU treatment in 20 patients with histologically verified, low‐risk superficial or nodular BCCs on the face (<20 mm) or trunk/extremities (<50 mm). After tumor demarcation guided by optical coherence tomography (OCT), BCCs were exposed to ablative fractional CO2 laser followed by 60 minutes topical cisplatin solution and 7‐day exposure to 5% 5‐FU cream under occlusion. After 30 days, treatment was repeated if any tumor residual was identified. Tumor response at day 30 and month 3 was assessed clinically as well as by OCT, reflectance confocal microscopy, and ultrasound, supplemented by histological verification at 3 months. Local skin reactions (LSRs) and side effects were evaluated on days 1, 3–5, 14, 30, and month 3. Drug detection in tumors and blood was performed in a subset of patients 1‐ and 24 hours after treatment.ResultsNineteen patients completed the trial, with 32% (6/19) receiving a single treatment and 68% (13/19) treated twice. At 3 months, clinical clearance was seen in 18/19 patients with a corresponding 94% (17/18) achieving histological clearance. Baseline tumor thickness and subtype did not influence treatment number or clearance rate (P ≥ 0.61). LSRs were well‐tolerated and consisted of erythema, edema, and erosion, followed by crusting by day 14. Erythema declined gradually by month 3, with 94% of patients and 79% of physicians rating cosmesis as “good” or “excellent.” Scarring or hyperpigmentation was noted in 50% and 56%, respectively, while pain and infection were not observed during the follow‐up period. Although chemotherapy uptake was visualized extending to deep skin layers, no systemic exposure to cisplatin or 5‐FU was detected in patient blood.ConclusionLaser‐assisted cisplatin + 5‐FU shows potential as an effective and tolerable treatment option for low‐risk BCC, particularly in instances where self‐application is not possible or where in‐office, non‐surgical therapy is preferred. Lasers Surg. Med. © 2020 Wiley Periodicals LLC
Combining Deep Learning With Optical Coherence Tomography Imaging to Determine Scalp Hair and Follicle Counts
Authors: Urban Gregor , Feil Nate , Csuka Ella , Hashemi Kiana , Ekelem Chloe , Choi Franchesca , Mesinkovska Natasha A. , Baldi Pierre 
Published: September 2020

Background and ObjectivesOne of the challenges in developing effective hair loss therapies is the lack of reliable methods to monitor treatment response or alopecia progression. In this study, we propose the use of optical coherence tomography (OCT) and automated deep learning to non‐invasively evaluate hair and follicle counts that may be used to monitor the success of hair growth therapy more accurately and efficiently.Study Design/Materials and MethodsWe collected 70 OCT scans from 14 patients with alopecia and trained a convolutional neural network (CNN) to automatically count all follicles present in the scans. The model is based on a dual approach of both detecting hair follicles and estimating the local hair density in order to give accurate counts even for cases where two or more adjacent hairs are in close proximity to each other.ResultsWe evaluate our system on 70 OCT manually labeled scans taken at different scalp locations from 14 patients, with 20 of those redundantly labeled by two human expert OCT operators. When comparing the individual human predictions and considering the exact locations of hair and follicle predictions, we find that the two human raters disagree with each other on approximately 22% of hairs and follicles. Overall, the deep learning (DL) system predicts the number of follicles with an error rate of 11.8% and the number of hairs with an error rate of 18.7% on average on the 70 scans. The OCT system can capture one scalp location in three seconds, and the DL model can make all predictions in less than a second after processing the scan, which takes half a minute using an unoptimized implementation.ConclusionThis approach is well‐positioned to become the standard for non‐invasive evaluation of hair growth treatment progress in patients, saving significant amounts of time and effort compared with manual evaluation.Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.