bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative analysis of circRNAs, miRNAs and mRNAs profiles reveal that ceRNAs networks in chicken intramuscular and abdominal adipogenesis
Authors: Zhang Meng , Han Yu , Zhai Yanhui , Ma Xiangfei , An Xinglan , Zhang Sheng , Li Ziyi 
Published: April 2020

Abstract
BackgroundTissue-specific fat deposition is regulated by a series of complex regulation mechanisms. Epigenetic regulations, such as circular RNAs (circRNAs), have been proved to be the crucial regulator of diseases, development, metabolism and adipogenesis. To investigate the functional roles of circRNAs in adipogenesis and tissue-specific fat deposition, we comprehensively analyzed the Ribo-Zero RNA-Seq and miRNAs data during chicken abdominal and intramuscular adipogenic differentiation. Results Here, we first reported circRNAs and miRNAs profiles during chicken adipogenic differentiation in adipocytes-derived from various adipose tissues. Large amounts of downregulated miRNAs might promote adipogenesis through activating their target genes which were related to fatty metabolism and adipogenic differentiation. Furthermore, we identified several candidate circRNAs by the correlation analysis between the expression levels of circRNAs and adipogenic genes, tissues as well as the dynamic expression patterns of circRNAs during adipogenic differentiation. Moreover, we constructed competing endogenous RNA (ceRNAs) networks during chicken intramuscular and abdominal adipogenesis through combining with miRNAs and mRNAs data. Several candidate circRNAs might affect adipogenesis by regulating miRNAs through PPAR and fatty acid metabolism related pathways, such as circLCLAT1, circFNDC3AL, circCLEC19A and circARMH1.ConclusionOver all, our result indicated that some tissue- or cell-specific circRNAs and miRNAs may have notable effects on chicken adipogenesis and tissue-specific fat deposition.
Investigation of Pindan Soil Modified with Polymer Stablisers for Road Pavement
Authors: PARK HYUN KYU , Lee Hyuk , Vimonsatit Vanissorn 
Published: April 2020

Abstract
Road failures are often caused by structural weaknesses, and particularly unsealed roads are vulnerable to water as water easily flows into road structures. Moisture susceptibility of materials is an important aspect when pavements are designed as moisture can weaken bonds between aggregates. Pindan soil is a red soil, known as a soft and moisture sensitive soil. Polymer stabilisers have been proved that they can improve soil mechanical properties by providing an internal waterproofing. Studies of the polymer-Pindan soil stabilisation have been focused on engineering performances, but literature shows little information on the fundamental information of Pindan soil. This project focuses on fundamental information of Pindan soil and its improved performances using polymer stabilisers. Plastic index, specific gravity and particle size distribution were tested to obtain the basic properties. Compaction, Unconfined Compressive Strength and California Bearing Ratio tests were performed to determine the mechanical properties. The chemical property was examined using X-ray diffraction. Furthermore, the waterproof effect of the polymers on the stabilised Pindan soil was investigated from capillary rise tests. In addition, the mechanical properties of individual soil grains were investigated using nanoindentation tests. The materials used for this investigation primarily consisted of Pindan soil collected in Broome, Western Australia, and three polymer products manufactured in Australia. Based on the results, it is evident that the failure behaviour, strain and strength as well as the basic properties of the soils are affected and changed by the Polymer stabilisers. The type of polymer influenced the optimum moisture contents and strengths rather than the amount of polymer. Similarly, Nanoindentation technology provided various information such as elastic modulus, hardness, packing density, stiffness, cohesion and fracture toughness of soils at nano-scales. Polymers can reduce water ingress and minimise moisture in the pavement structures. Thus, the structures can maintain its strength and prevent deformation, which will increase the lifetime of unsealed pavements.
Milan criteria in the MELD era – Is it justifiable to extend the limits for orthotopic liver Transplantation?
Authors: Morgül Mehmet Haluk , Felgendreff Philipp , Kienlein Andreas , Gauger Ulrich , Semmling Katrin Semmling , Hau Hans-Michael , Tautenhahn Hans-Michael , Bartels Michael 
Published: April 2020

Abstract
BackgroundThe Milan criteria (MC) are widely used for the indication of liver transplantation (LTx) in hepatocellular carcinoma (HCC). Good long-term results have also been reported following LTx for patients exceeding the MC. In this article, we compare the overall and recurrence-free survival of our patients fulfilling and exceeding the MC according to the posttransplant histopathological results.Patients and MethodsData from 120 patients with HCC (22 females and 98 males) were analyzed. The median patient age was 61 years (Q1, Q3: 54.7, 65.4), and the median MELD score was 11 (Q1, Q3: 8, 15). The median follow-up period was 53 months (Q1, Q3: 16.6, 78). Patients were categorized into established criteria (MC, up-to-seven (UTS), Asan criteria, AFP score), and the outcome of the individual groups was compared.ResultsSeventy-four of 120 patients fulfilled the MC, 86 patients met the UTS criteria, 85 patients fulfilled the Asan criteria, and 79 patients had an AFP score less than or equal to 2. The 1- and 5-year survival rates of all patients were 76.7% and 55.6%, respectively. In total, 14.2% of all patients (5.4% of patients who met the MC, 7% of patients who met the UTS criteria, 5.9% of patients who met the Asan criteria, and 6.3% of patients who had an AFP score less than 2) experienced recurrence.ConclusionsThe outcomes of the patients were comparable to those reported in the current literature. In our population, similar recurrence and survival rates of the patients were noted for patients fulfilling the UTS criteria irrespective of fulfilling or exceeding the MC. Consequently, we consider using UTS criteria as the extended criterion for LTx indication.
Local Tirofiban Infusion for Remnant Stenosis in Large Vessel Occlusion: Tirofiban ASSIST study
Authors: Kim Yong-Won , Sohn Sung-Il , Yoo Joonsang , Hong Jeong-Ho , Kim Chang-Hyun , Kang Dong-Hun , Kim Yong-Sun , Lee Seong-Joon , Hong Ji Man , Choi Jin Wook , Hwang Yang-Ha , Lee Jin Soo 
Published: April 2020

Abstract
Background
Compared to embolic occlusions, intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusions (LVOs) often require rescue treatment following mechanical thrombectomy (MT). Herein, we hypothesized that local tirofiban infusion can be effective and safe for remnant stenosis in LVO during endovascular treatment, and can improve clinical outcomes.
Methods
This observational multicenter registry study (January 2011 to February 2016) included patients with ICAS who underwent endovascular treatment for LVO within 24 hours after stroke onset. An underlying fixed focal stenosis at the occlusion site observed on a cerebral angiography during and after MT was retrospectively determined as a surrogate marker of ICAS. Procedural and clinical outcomes were compared between the tirofiban and non-tirofiban groups.
Results
Patients were older (median, 71 years vs. 63 years, p = 0.015) and the onset to puncture time was longer (median, 395 min vs. 275 min, p = 0.036) in the tirofiban group than in the non-tirofiban group. Final reperfusion success (modified Treatment In Cerebral Ischemic 2b–3) was more frequent (86.4% vs. 42.4%, p = 0.016) and post-procedure parenchymal hematoma type 2 and/or thick subarachnoid hemorrhages were less frequent (5.1% vs. 15.3%, p = 0.068) in the tirofiban group. The frequency of favorable outcomes 3 months after endovascular revascularization therapy (modified Rankin Scale 0–2) was significantly higher in the tirofiban group (52.5% vs. 32.2%, p = 0.025) and tirofiban administration was an independent predictor of favorable outcomes (odds ratio, 4.013; 95% confidence interval, 1.300–12.386; p = 0.016).
Conclusions
Local tirofiban infusion may be an effective and safe adjuvant treatment option for patients with ICAS-LVO.
A tentacle for every occasion: comparing the hunting tentacles and sweeper tentacles, used for territorial competition, in the coral Galaxea fascicularis
Authors: Yosef Oshra , Popovits Yotam , Malik Assaf , Ofek-Lalzer Maya , Mass Tali , Sher Daniel 
Published: April 2020

Abstract
Background:Coral reefs are among the most diverse, complex and densely populated marine ecosystems. To survive, morphologically simple and sessile cnidarians have developed mechanisms to catch prey, deter predators and compete with adjacent corals for space, yet the mechanisms underlying these functions are largely unknown. Here, we characterize the histology, toxic activity and gene expression patterns in two different types of tentacles from the scleractinian coral Galaxea fascilcularis – catch tentacles (CTs), used to catch prey and deter predators, and sweeper tentacles (STs), specialized tentacles used for territorial aggression. Results:STs exhibit more mucocytes and higher expression of mucin genes than CTs, and lack the ectodermal cilia used to deliver food to the mouth and remove debris. STs and CTs also express different sensory g-protein coupled receptors, suggesting they may employ different sensory pathways. Each tentacle type has a different complement of stinging cells (nematocytes), and the expression in the two tentacles of genes encoding structural nematocyte proteins suggests the stinging cells develop within the tentacles. CTs have higher neurotoxic and hemolytic activities, consistent with a role in prey capture, whereas the STs have higher phospholipase A2 activity, which we speculate may have a role in inducing tissue damage during territorial aggression. The toxin genes expressed in each tentacle are also different. Conclusions:These results show that the same organism utilizes two distinct tentacle types, each equipped with a different venom apparatus and toxin composition, for prey capture and defense and for territorial aggression.
Precarious working conditions and psychosocial work stress act as a risk factor for symptoms of postpartum depression during maternity leave: results from a longitudinal cohort study
Authors: Karl Marlene , Schaber Ronja , Kress Victoria , Kopp Marie , Martini Julia , Weidner Kerstin , Garthus-Niegel Susan 
Published: April 2020

Abstract
Introduction: Most Western women work during their reproductive years, but past research has often neglected the influence of work-related factors on postpartum health. Especially postpartum depression (PPD) puts an enormous psychological burden on mothers. Therefore, this study aims to investigate the prospective impact of precarious working conditions and psychosocial work stress (such as work-privacy conflict and effort-reward imbalance at the job) during pregnancy on symptoms of maternal PPD. Methods: In the prospective-longitudinal cohort study DREAM (DResdner Studie zu Elternschaft, Arbeit und Mentaler Gesundheit), N = 587 employed women were questioned about their work during pregnancy and mental health 8 weeks after delivery. Results: Multiple regression analyses revealed that work-privacy conflict, low reward at work, and precarious working conditions significantly predicted symptoms of PPD, even when controlling for lifetime depression, anxiety, education, parity, and age. Conclusion: Our results indicate that psychosocial work stress and precarious working conditions have important implications for maternal peripartum mental health and might act as prospective risk factors for PPD even during the period of maternal leave. Hence, preventative measures targeting work life need to be investigated in more detail.
The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the Grading of Cerebral Gliomas: A Meta-Analysis
Authors: Jixin Luan , Wu Mingzhen , Wang Xiaohui , Qiao Lishan , Guo Guifang , Zhang Chuanchen 
Published: April 2020

Abstract
Objective
To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enhanced magnetic resonance imaging(DSC-MRI), and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) to grade cerebral gliomas.
Methods
Literature regarding ASL, DSC-MRI, or DKI in cerebral glioma grading in both English and Chinese were searched from PubMed, Embase, Web of Science, CBM, China National Knowledge Infrastructure (CNKI), and Wanfang Database as of April 2019. A Meta-Analysis was performed to evaluate the efficacy of ASL, DSC-MRI, and DKI in the grading of cerebral glioma.
Result
A total of 54 articles (11 in Chinese and 43 in English) were included. Three quantitative parameters in the grading of cerebral glioma, rCBF in ASL, rCBV in DSC-MRI,and MK in DKI had an overall sensitivity of 0.88[95%CI(0.83,0.92)], 92[95%CI(0.83,0.96)],0.88[95%CI(0.82,0.92)], and an overall specificity of 0.91[95%CI(0.84,0.94)],0.81[95%CI(0.73,0.88)], 0.86[95%CI(0.78,0.91)] respectively. The overall area under the ROC curve were 0.95[95%CI(0.93,0.97)], 0.91[95%CI(0.89,0.94)], 0.93[95%CI(0.91,0.95)] respectively.
Conclusion
Quantitative parameters rCBF, rCBV and MK have high diagnostic efficacy for preoperative grading of cerebral gliomas.
Giving syphilis and gonorrhea to friends: Using in-person friendship networks to find additional cases of gonorrhea and syphilis
Authors: Rosenbaum Janet E. , Jennings Jacky , Ellen Jonathan , Borkovic Laurel , Scott Jo-Ann , Wylie Charleen , Rompalo Anne 
Published: April 2020

Abstract
Background: Syphilis and gonorrhea reached an all-time high in 2018, including in populations that stigmatize same-sex sexual contact. The resurgence of syphilis and gonorrhea requires innovative methods of sexual contact tracing that encourage disclosure of same-sex contacts. Over 75% of Grindr users report seeking “friendship,” so this study asked people diagnosed with syphilis and gonorrhea to identify their friends.Methods: Patients at the two Baltimore STI clinics and the Baltimore City Health Department were asked 12 questions to elicit members of their friendship networks before eliciting sexual networks. The study included 353 index cases and 172 contacts, yielding a friendship network of 331 non-isolates (n=331) and sexual-only network of 140 non-isolates. The data were plotted and analyzed using exponential family random graph analysis.Results: Eliciting respondents’ in-person social contacts yielded 12 syphilis cases and 6 gonorrhea cases in addition to the 16 syphilis cases and 4 gonorrhea cases that would have been found with sexual contacts alone. Syphilis is clustered within sexual (odds ratio=2.2, 95% confidence interval (1.36, 3.66)) and social contacts (OR=1.31, 95% CI (1.02, 1.68)). Gonorrhea is clustered within reported social (OR=1.56, 95% CI (1.22, 2.00)) but not sexual contacts (OR=0.98, 95% CI (0.62, 1.53)). Conclusions: Eliciting the friendship networks of people diagnosed with syphilis and gonorrhea may find members of their sexual networks, drug use networks, or people of similar STI risk. Friendship networks include more diagnosed cases of syphilis and gonorrhea than sexual networks alone, especially among populations with many non-disclosing MSM and WSW.
Relatively semi-conservative replication and a folded slippage model for simple sequence repeats
Authors: Tan Zhongyang , Zhang Hongxi , Li Douyue , Zhao Xiangyan , Pan Saichao , Wu Xiaolong , Peng Shan , Huang Hanrou , Shi Ruixue 
Published: April 2020

Abstract
BackgroundSimple sequence repeats (SSRs) are found ubiquitously in almost all genome, and their formation mechanism is ambiguous yet.ResultsHere, the SSRs were analyzed in 55 randomly selected segments of genomes from a fairly wide range of species, with introducing more open standard for extensively mining repeats. A high percentage of repeats were discovered in these segments, which is inconsistent with the current theory suggested that repeats tend to disappear over long-term evolution. Therefore, a mechanism is most probably responsible for continually producing repeats during replication to balance continuous repeat disappearance, which may makes the replicating process relatively semi-conservative. To improve the current straight-line slippage model, we proposed a folded slippage model involving the geometric space of nucleotides and hydrogen bond stability to explain the high-percent SSR occurrence, which can describe SSR expansion and contraction more reasonably. And analysis of external forces in the folding template strands suggested that the microsatellites tend to expand than contract.ConclusionOur research may provide implements for contributions of microsatellites to genome evolution and complement semi-conservative replication.
Using Kano diagrams to display the most cited article types, affiliated countries, authors and MeSH terms on spinal surgery in recent 12 years
Authors: Chou Po-Hsin , Yeh Yu-Tsen , Kan Wei-Chih , Wei Chien Tsai , Kuo Shu-Chun 
Published: April 2020

Abstract
Background: Citation analysis has been increasingly applied to assess the quantity and quality of scientific research in various fields worldwide. However, these analyses on spinal surgery do not provide visualization of results. This study aims (1) to evaluate the worldwide research citations and publications on spinal surgery and (2) to provide visual representations using Kano diagrams onto the research analysis for spinal surgeons and researchers.Methods: Article abstracts published between 2007 and 2018 were downloaded from PubMed Central(PMC) in 5 journals, including Spine, European Spine Journal, The Spine Journal, Journal of Neurosurgery: Spine, and Journal of Spinal Disorders and Techniques. The article types, affiliated countries, authors, and Medical subject headings (MeSH terms) were analyzed by the number of article citations using x-index. Choropleth maps and Kano diagrams were applied to present these results. The trends of MeSH terms over the years were plotted and analyzed.Results: A total of 18,808 publications were extracted from the PMC database, and 17,245 were affiliated to countries/areas. The 12-year impact factor for the five spine journals is 5.758. We observed that (1) The largest number of articles on spinal surgery was from North America(6417, 37.21%). Spine earns the highest x-index(=82.96). Comparative Study has the highest x-index(=66.74) among all article types. (2) The United States performed exceptionally in x-indexes (=56.86 and 44.5) on both analyses done on the total 18,808 and the top 100 most cited articles, respectively. The most influential author whose x-index reaches 15.11 was Simon Dagenais from the US. (3) The most cited MeSH term with an x-index of 23.05 was surgery based on the top 100 most cited articles. The most cited article (PMID=18164449) was written by Dagenais and his colleagues in 2008. The most productive author was Michael G Fehlings, whose x-index and the author's impact factor are 13.57(=√(13.16*14)) and 9.86(=331.57/33.64), respectively.Conclusions: There was a rapidly increasing scientific productivity in the field of spinal surgery in the past 12 years. The US has extraordinary contributions to the publications. Furthermore, China and Japan have increasing numbers of publications on spinal surgery. This study with Kano diagrams provides an insight into the research for spinal surgeons and researchers.
Maximum entropy method-based forest fire prediction mapping of Sikkim Himalaya.
Authors: Banerjee Polash 
Published: April 2020

Abstract
The recent episodes of forest fire in Brazil and Australia of 2019 are tragic reminders of the hazards of the forest fire. Globally incidents of forest fire events are in the rise due to human encroachment into wilderness and climate change. Sikkim with a forest cover of more than 47%, suffers seasonal instances of frequent forest fire during the dry winter months. To address this issue, a GIS-aided and MaxEnt machine learning-based forest fire prediction map has been prepared using forest fire inventory database and maps of environmental features. The study indicates that amongst the environmental features, population density and proximity to roads are the major determinants of the forest fire. This indicates the role of human activities on the incidences of a forest fire. Model validation criteria like ROC curve, correlation coefficient and Cohen’s Kappa show a good predictive capability (AUC = 0.95, COR = 0.77, κ = 0.77). The outcomes of this study in the form of a forest fire prediction map can aid the stakeholders of the forest in taking informed mitigation measures.
Overexpression of TPT1-AS1 and SAMMSON and down expression of LINC00961 associated with Advanced Grades of Gastric Cancer
Authors: Amini Mohammad Amin , Karimi Jamshid , Khodadadi Iraj , Tavilani Heidar , Talebi Seyed Saman , Afshar Behrouz 
Published: April 2020

Abstract
Background

One of the deadliest cancers in the world is gastric cancer. Long non-coding RNAs play prominent roles in cancer. LINC00961, TPT1-AS1, and SAMMSON have recently been discovered, which significantly contribute in various cancers and can affect the tumor size, grade of tumors and the metastasis condition. The aim of this study was to determine LINC00961, SAMMSON and TPT1-AS1 expression in gastric cancer tissues in comparison with healthy adjacent tissues.
Methods

The number of cancerous tissues and control groups was calculated to be at 40 (n = 40) and were analyzed by Quantitative real-time polymerase chain reaction.
Results

We found that overexpression of TPT1-AS1 and SAMMSON, and downexpression of LINC00961 in cancerous tissues in comparison with healthy adjacent tissues. A positive association between TPT1-AS1 and SAMMSON expression and tumor grade was observed. The level of mRNA folding change increased in cancer group compared to control group and *P < 0.05 is considered for mRNA folding change.
Conclusion

Finally, we found that overexpression of TPT1-AS1 and SAMMSON, and downexpression of LINC00961 were observed significantly in gastric cancer tissues in comparison with adjacent non-cancerous tissues. These lncRNAs were suggested as potential tumor markers for the diagnosis and treatment of gastric cancer.