bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of miR-26a-5p Suppresses Tau Phosphorylation and Aβ Accumulation in the Alzheimer’s Disease Mice by Targeting DYRK1A
Authors: Liu Yanni , Wang Lin , Xie Fuheng , Wang Xiao , Hou Yuanyuan , Wang Xiaomeng , Liu Juan 
Published: April 2020

Objective:
It is reported that miR-26a-5p could regulate neuronal development, but its
underlying mechanisms in Alzheimer’s disease (AD) progression is unclear.

Methods:
APP (swe)/PS1 (ΔE9) transgenic mice served as AD mice. Morris water maze test was
used to measure the spatial learning and memory ability of mice. The expressions of miR-26a-5p,
DYRK1A, phosphorylated-Tau, Aβ40, and Aβ42 were detected. The relationship between miR-
26a-5p and DYRK1A was explored using dual luciferase reporter assay. The effects of miR-26a-
5p on AD mice was determined.

Results:
AD mice walked a lot of wrong ways to find the platform area and the latency time to
reach the platform was longer. There was low expression of MiR-26a-5p in AD mice. Overexpression
of miR-26a-5p inhibited Tau phosphorylation and Aβ accumulation. MiR-26a-5p negatively
regulated DYRK1A via targeting its 3’UTR. In vivo, increased miR-26a-5p down-regulated Aβ40,
Aβ42, p-APP and p-Tau levels in AD mice through decreasing DYRK1A. Meanwhile, the swimming
path and the latency time, to reach the platform, was shorten after enhancing miR-26a-5p expression.

Conclusion:
Overexpression of miR-26a-5p could repress Tau phosphorylation and Aβ accumulation
via down-regulating DYRK1A level in AD mice.
Effectiveness of Exergaming in Improving Cognitive and Physical Function in People With Mild Cognitive Impairment or Dementia: Systematic Review
Authors: Zhao Yinan , Feng Hui , Wu Xinyin , Du Yan , Yang Xiufen , Hu Mingyue , Ning Hongting , Liao Lulu , Chen Huijing , Zhao Yishan 
Published: April 2020

Background
Individuals with mild cognitive impairment and dementia have impaired physical and cognitive functions, leading to a reduced quality of life compared with those without such impairment. Exergaming, which is defined as a combination of exercise and gaming, is an innovative, fun, and relatively safe way to exercise in a virtual reality or gaming environment. Therefore, exergaming may help people living with mild cognitive impairment or dementia to overcome obstacles that they may experience regarding regular exercise and activities.

Objective
The aim of this systematic review was to review studies on exergaming interventions administered to elderly individuals with mild cognitive impairment and dementia, and to summarize the results related to physical and cognitive functions such as balance, gait, executive function, and episodic memory.

Methods
We searched Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, PsycINFO, Amed, and Nursing Database for articles published from the inception of the respective databases to January 2019. We included all clinical trials of exergaming interventions in individuals with mild cognitive impairment and dementia for review. The risk of bias was independently evaluated by two reviewers using the Cochrane Collaboration and Risk of Bias in Non-randomized Studies of Interventions tools.

Results
Ten studies involving 702 participants were included for review. There was consistent evidence from 7 studies with a low risk of bias showing statistically significant effects of exergaming on cognitive functioning in people with mild cognitive impairment and dementia. With respect to physical function, 3 of 5 full-scale studies found positive results, and the intensity of most games was classified as moderate.

Conclusions
Overall, exergaming is an innovative tool for improving physical and cognitive function in people with mild cognitive impairment or dementia, although there is high heterogeneity among studies in terms of the duration, frequency, and gaming platform used. The quality of the included articles was moderate to high. More high-quality studies with more accurate outcome indicators are needed for further exploration and validation of the benefits of exergaming for this population.
Categorization of Third-Party Apps in Electronic Health Record App Marketplaces: Systematic Search and Analysis
Authors: Ritchie Jordon , Welch Brandon 
Published: April 2020

Background
Third-party electronic health record (EHR) apps allow health care organizations to extend the capabilities and features of their EHR system. Given the widespread utilization of EHRs and the emergence of third-party apps in EHR marketplaces, it has become necessary to conduct a systematic review and analysis of apps in EHR app marketplaces.

Objective
The goal of this review is to organize, categorize, and characterize the availability of third-party apps in EHR marketplaces.

Methods
Two informaticists (authors JR and BW) used grounded theory principles to review and categorize EHR apps listed in top EHR vendors’ public-facing marketplaces.

Results
We categorized a total of 471 EHR apps into a taxonomy consisting of 3 primary categories, 15 secondary categories, and 55 tertiary categories. The three primary categories were administrative (n=203, 43.1%), provider support (n=159, 33.8%), and patient care (n=109, 23.1%). Within administrative apps, we split the apps into four secondary categories: front office (n=77, 37.9%), financial (n=53, 26.1%), office administration (n=49, 24.1%), and office device integration (n=17, 8.4%). Within the provider support primary classification, we split the apps into eight secondary categories: documentation (n=34, 21.3%), records management (n=27, 17.0%), care coordination (n=23, 14.4%), population health (n=18, 11.3%), EHR efficiency (n=16, 10.1%), ordering and prescribing (n=15, 9.4%), medical device integration (n=13, 8.2%), and specialty EHR (n=12, 7.5%). Within the patient care primary classification, we split the apps into three secondary categories: patient engagement (n=50, 45.9%), clinical decision support (n=40, 36.7%), and remote care (n=18, 16.5%). Total app counts varied substantially across EHR vendors. Overall, the distribution of apps across primary categories were relatively similar, with a few exceptions.

Conclusions
We characterized and organized a diverse and rich set of third-party EHR apps. This work provides an important reference for developers, researchers, and EHR customers to more easily search, review, and compare apps in EHR app marketplaces.
Perspectives of Patients and Professionals on Information and Education After Myocardial Infarction With Insight for Mixed Reality Implementation: Cross-Sectional Interview Study
Authors: Hilt Alexander D , Mamaqi Kapllani Kevin , Hierck Beerend P , Kemp Anne C , Albayrak Armagan , Melles Marijke , Schalij Martin J , Scherptong Roderick W C 
Published: April 2020

Background
Patient education is crucial in the secondary prevention of cardiovascular disease. Novel technologies such as augmented reality or mixed reality expand the possibilities for providing visual support in this process. Mixed reality creates interactive digital three-dimensional (3D) projections overlaying virtual objects on the real-world environment. While augmented reality only overlays objects, mixed reality not just overlays but anchors virtual objects to the real world. However, research on this technology in the patient domain is scarce.

Objective
The aim of this study was to understand how patients perceive information provided after myocardial infarction and examine if mixed reality can be supportive in this process.

Methods
In total, 12 patients that experienced myocardial infarction and 6 health care professionals were enrolled in the study. Clinical, demographic, and qualitative data were obtained through semistructured interviews, with a main focus on patient experiences within the hospital and the knowledge they gained about their disease. These data were then used to map a susceptible timeframe to identify how mixed reality can contribute to patient information and education.

Results
Knowledge transfer after myocardial infarction was perceived by patients as too extensive, not personal, and inconsistent. Notably, knowledge on anatomy and medication was minimal and was not recognized as crucial by patients, whereas professionals stated the opposite. Patient journey analysis indicated the following four critical phases of knowledge transfer: at hospital discharge, at the first outpatient visit, during rehabilitation, and during all follow-up outpatient visits. Important patient goals were understanding the event in relation to daily life and its implications on resuming daily life. During follow-up, understanding physical limitations and coping with the condition and medication side effects in daily life emerged as the most important patient goals. The professionals’ goals were to improve recovery, enhance medication adherence, and offer coping support.

Conclusions
There is a remarkable difference between patients’ and professionals’ goals regarding information and education after myocardial infarction. Mixed reality may be a practical tool to unite perspectives of patients and professionals on the disease in a more even manner, and thus optimize knowledge transfer after myocardial infarction. Improving medication knowledge seems to be a feasible target for mixed reality. However, further research is needed to create durable methods for education on medication through mixed reality interventions.
Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD
Authors: Steubl Dominik , Schneider Markus P. , Meiselbach Heike , Nadal Jennifer , Schmid Matthias C. , Saritas Turgay , Krane Vera , Sommerer Claudia , Baid-Agrawal Seema , Voelkl Jakob , Kotsis Fruzsina , Köttgen Anna , Eckardt Kai-Uwe , Scherberich Jürgen E. ,   GCKD Study Investigators
Published: April 2020

Background and objectives
Uromodulin is exclusively produced by tubular epithelial cells and released into urine and serum. Higher serum uromodulin has been associated with lower risk for kidney failure in Chinese patients with CKD and with lower risk for mortality in the elderly and in patients undergoing coronary angiography. We hypothesized that lower serum uromodulin is associated with mortality, cardiovascular events, and kidney failure in white patients with CKD.

Design, setting, participants, & measurements
We measured serum uromodulin in 5143 participants enrolled in the German CKD (GCKD) study. The associations of baseline serum uromodulin with all-cause mortality, major adverse cardiovascular events (MACE; a composite of cardiovascular mortality, nonfatal myocardial infarction or stroke, or incident peripheral vascular disease), and kidney failure (dialysis or transplantation) were evaluated using multivariable Cox proportional hazard regression analyses in a cohort study design, adjusting for demographics, eGFR, albuminuria, cardiovascular risk factors, and medication.

Results
The mean age of participants was 60±12 years, 60% were male. Mean serum uromodulin concentration was 98±60 ng/ml, eGFR was 49±18 ml/min per 1.73 m2, and 78% had eGFR <60 ml/min per 1.73 m2. Participants in lower serum uromodulin quartiles had lower eGFR and higher albuminuria, prevalence of diabetes, hypertension, coronary artery disease, and more frequent history of stroke at baseline. During a follow-up of 4 years, 335 participants died, 417 developed MACE, and 229 developed kidney failure. In multivariable analysis, the highest serum uromodulin quartile was associated with lower hazard for mortality (hazard ratio [HR], 0.57; 95% CI, 0.38 to 0.87), MACE (HR, 0.63; 95% CI, 0.45 to 0.90), and kidney failure (HR, 0.24; 95% CI, 0.10 to 0.55) compared with the lowest quartile.

Conclusions
Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD.

Clinical Trial registry name and registration number
Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971.
A Pharmacologic “Stress Test” for Assessing Select Antioxidant Defenses in Patients with CKD
Authors: Zager Richard A. , Johnson Ali C.M. , Guillem Alvaro , Keyser Jeff , Singh Bhupinder 
Published: April 2020

Background and objectives
Oxidative stress is a hallmark and mediator of CKD. Diminished antioxidant defenses are thought to be partly responsible. However, there is currently no way to prospectively assess antioxidant defenses in humans. Tin protoporphyrin (SnPP) induces mild, transient oxidant stress in mice, triggering increased expression of select antioxidant proteins (e.g., heme oxygenase 1 [HO-1], NAD[P]H dehydrogenase [quinone] 1 [NQO1], ferritin, p21). Hence, we tested the hypothesis that SnPP can also variably increase these proteins in humans and can thus serve as a pharmacologic “stress test” for gauging gene responsiveness and antioxidant reserves.

Design, setting, participants, & measurements
A total of 18 healthy volunteers and 24 participants with stage 3 CKD (n=12; eGFR 30–59 ml/min per 1.73 m2) or stage 4 CKD (n=12; eGFR 15–29 ml/min per 1.73 m2) were injected once with SnPP (9, 27, or 90 mg). Plasma and/or urinary antioxidant proteins were measured at baseline and for up to 4 days post-SnPP dosing. Kidney safety was gauged by serial measurements of BUN, creatinine, eGFR, albuminuria, and four urinary AKI biomarkers (kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, cystatin C, and N-acetyl glucosaminidase).

Results
Plasma HO-1, ferritin, p21, and NQO1 were all elevated at baseline in CKD participants. Plasma HO-1 and urine NQO1 levels each inversely correlated with eGFR (r=−0.85 to −0.95). All four proteins manifested statistically significant dose- and time-dependent elevations after SnPP injection. However, marked intersubject differences were observed. p21 responses to high-dose SnPP and HO-1 responses to low-dose SnPP were significantly suppressed in participants with CKD versus healthy volunteers. SnPP was well tolerated by all participants, and no evidence of nephrotoxicity was observed.

Conclusions
SnPP can be safely administered and, after its injection, the resulting changes in plasma HO-1, NQO1, ferritin, and p21 concentrations can provide information as to antioxidant gene responsiveness/reserves in subjects with and without kidney disease.

Clinical Trial registry name and registration number
A Study with RBT-1, in Healthy Volunteers and Subjects with Stage 3–4 Chronic Kidney Disease, NCT0363002 and NCT03893799
Issues Faced by Minority Ethnic Groups’ Students Reflected in Their Writing
Authors: Wiraatmaja Triastama 
Published: April 2020

This research attempted to determine issues faced by minority ethnic groups’ students in English Language Education Department in private university in Malang, and whether ethnicity and social aspects played significant roles in the students’ language proficiency reflected in their vocabulary in writing class. The researcher analysed writing samples taken from 16 students from both minority and majority ethnic groups by utilising Voyant Tools which focused on vocabulary density and average words per sentence. Followed with spreading questionnaires to eight students of minority ethnic groups and interviewing two of them who earned highest scored based on Voyant Tools. Those sessions were analysed with Thick Description to focus on related issues regarding vocabulary proficiency and ethnicities. The results taken from Voyant Tools indicated that students from minority ethnic groups were lesser than the students from majority one’s. Those results depicted the vocabulary proficiency of students from minority ethnic groups in writing, and those results were affected by educational deprived in their origins, and verbal abuse regarding their ethnicity. The researcher discovered that verbal abuse towards ethnicity regarded as individual discrimination that strengthens the majority’s idea to emphasise their superiority over the inferior. People tend to overlook the fact that verbal abuse among students was existed in universities and it affecting students’ performance. This notion was supported by the result taken from Voyant Tools in which the result shown that the minority ethnic groups were lesser than majority one’s and the effect were reflected at their writing, notably their vocabulary proficiency.
Nilai Religiositas Pupuh Kasmaran dalam Lontar Yusuf dan Relevansinya dengan Kehidupan di Era Disruptif
Authors: Rakhmi Martina Puspita 
Published: April 2020

Keberadaan sastra daerah memiliki beragam fungsi. Salah satunya sebagai penyebar ajaran agama. Banyuwangi merupakan salah satu daerah yang memanfaatkan sastra daerah sebagai penyebaran ajaran agama Islam, melalui Lontar Yusup Banyuwangi. Dalam Lontar Yusup Banyuwangi, nilai religiositas adalah yang paling dominan. Untuk itu, dalam penelitian ini dikaji nilai-nilai religiositas dengan memfokuskan pengkajian pada Pupuh Kasmaran. Selain itu juga dibahas relevansi nilai religiositas dengan kehidupan di era disruptif. Teknik pengumpulan data melalui studi dokumen. Data dianalisis dengan metode analisis-deskriptif. Dari hasil penelitian diketahui terdapat empat nilai religiositas: (1) keimanan terhadap Tuhan, (2) keteringatan manusia terhadap sifat Tuhan, (3) ketaatan manusia terhadap Tuhan dan (4) kepasrahan manusia terhadap Tuhan, serta empat dimensi religiositas: dimensi praktis, dimensi ideologis, dimensi pengetahuan, dan dimensi perasaan. (2) nilai religiositas pada PK sangat relevan dalam kehidupan manusia di era disruptif.
Consideration of Intelligent Applications to Support Diabetic Patients: A Scoping Review for Nutrition Mobile Phone Apps
Authors: Jamshidnezhad Amir , Koohmareh Zahra , Pazahr Ali 
Published: April 2020

Objectives: Identify the functionality of smart applications in the mobile platform for controlling, teaching and healthy lifestyles in the field of nutrition for diabetic patients.
Method: Current review was conducted on the mobile platform to consider the functionalities of available applications to support the diabetic patients with the intelligent tools. The results of inclusion criteria (such as nutrition, weight control, blood pressure, education and interactive analysis tools) were evaluated and organized in the form of a scoping review. All applications in the systematic search were independent of both operating systems. The search samples were found in May 2018 by experts of medical informatics.
Results: 273 potential applications were identified according to the results of the inclusion criteria with evidence based strategies and systematic evaluations to find the apps for diabetic patients. Approximately 29% of apps in both stores (79/273) met primary assessment criteria. Of these, 40 % of apps (32/79) excluded of more consideration due to lack in the most criteria of this study. The remaining apps are described as follows: 8% of total apps (22/273) and 4% of the apps (11/273) met general criteria and all criteria (including general and special) in the Google play store, respectively. Only 2 apps met general criteria with the Apple iOS while none of them covered with special criteria according to the objectives of this study.
Conclusion: There are various applications for control, education, and self-care in diabetes. Google is an acceptable platform for developers interested in examining interactive apps and techniques in disease control, education and healthy lifestyle programs.
Mikoriza ve Oksin Uygulamalarının Kuşburnu (Rosa canina L.) Çeliklerinin Çoğaltılması Üzerine Etkisi
Authors: DURMUŞ KINIK Elif , ÇELİKEL Fisun Gürsel 
Published: April 2020

Rosa canina L. çelikleri sonbahar mevsiminde OMÜ Kurupelit Kampüsü’nden temin
edilmiştir. Bitkilerde aynı yılın
sürgünlerinden alınan yarı odun çelikler 10-15 cm uzunluğunda hazırlanmıştır.
Çeliklere mikoriza ve 1000 mg L-1 oksin (IBA) ayrı ayrı ve her iki
uygulama birlikte yapılmıştır. Mikoriza uygulaması için hazırlanan çözeltide
çelikler 2 dakika bekletildikten sonra köklendirme ortamına dikilmiştir.
Mikoriza + IBA uygulamasında ise çelikler önce 10 saniye IBA çözeltisinde
bekletildikten sonra mikoriza uygulanmıştır. Sisleme ve alttan ısıtma sistemi
olan köklendirme masasında 1:1 oranında torf ve perlit karışımı kullanılmıştır.
Çeliklerde köklenme oranı ve köklenme derecesi (kök yumağının eni ve boyu ile
kök sayısı) saptanmıştır. Köklenen çelikler bir litrelik plastik saksılarda
aynı karışıma dikildikten sonra saksıların yarısına 125 ml mikoriza çözeltisi
sulamadan sonra verilmiştir. Çalışma sonucunda; çeliklerde en yüksek köklenme
oranı (%60) Mikoriza+IBA uygulamasından elde edilmiştir. Kontrolde %10 olan
köklenme oranı mikoriza ile %40’a çıkmıştır. Genel olarak, mikoriza uygulaması
köklenme kalitesini (kök yumağı eni, kök boyu ve kök sayısı) önemli derecede
yükseltmiştir. Uygulamalar kök sayısını çelik başına 0.2 adetten 3’e, kök
yumağı eni ve kök boyunu sırasıyla 1 ve 0.5 mm’den 9 ve 17.5 mm’e çıkarmıştır.
Şaşırtma sonrası saksılarda yapılan mikoriza uygulaması, köklü çeliklerin
yaşama oranını %85.7’den %90’a artırmıştır.
Farklı Sodyum Değerlerine Sahip Sulama Sularının Kırmızı Lahana (Brassica oleracea var. capitata f. rubra) Bitkisinde Bazı Toprak ve Bitki Özelliklerine Etkisi
Authors: TEMİZEL Kadir Ersin , TOK Sedat 
Published: April 2020

Sodyumlu toprakların oluşumunda en önemli
etkenlerden biri de sulama suları içindeki sodyum düzeyidir. Her sulama
yapıldığında tarım alanlarındaki sodyum birikmesi, bitki aksamlarındaki sodyum
değerlerini değiştirebileceği gibi toprağın değişebilir sodyum yüzdesi (ESP), toprak
tuzluluğu (ECe) ve kullanılabilir sulama suyu miktarı (AWC) gibi özelliklerini
de etkilemektedir. Bu çalışmada kırmızı lahanaya tuzluluk değerleri aynı fakat
sodyum adsorbsiyon değerleri farklı (SAR0, SAR5, SAR15, SAR30 ve SAR40) 5
farklı sulama suyu uygulanmıştır. Parametre olarak farklı katmanlar için
topraktaki değişebilir sodyum yüzdesi (ESP), toprak tuzluluğu (ECe), sulama
suyu miktarları (IW) ve bitki yapraklarındaki sodyum miktarları incelenmiştir. Her
saksı tesadüf parselleri deneme desenine göre 5 tekerrür olacak şekilde yerleştirilmiştir.
İstatistiksel olarak her parametrede önemli farklılıklar gözlemlenmiştir.
Toprak ESP değerlerine bakıldığında birinci ve ikinci katmanda istatistiksel
olarak bütün uygulamalar için ayrı gruplar oluşmuştur. En yüksek ESP değeri
SAR40 uygulamasının ikinci katmanında 9.39 olarak belirlenirken, en düşük değer
ise SAR0 uygulamasının birinci katmanında 2.42 olarak belirlenmiştir. Uygulamalara
göre yaprakta biriken sodyum düzeylerinde de farklılıklar bulunmuştur. En
yüksek sodyum değeri SAR40 uygulamasında 60 ppm olacak şekilde meydana
gelirken, en düşük sodyum miktarı SAR0 uygulamasında 10 ppm olacak şekilde
meydana gelmiştir. Sonuç olarak, sulama
sularında SAR değerlerinin artması hem toprak hem de bitki yaprak aksamında
önemli etkileşimlere sebep olmuştur.
El ideal de brevedad en la prensa cómica de entreguerras: la revista Muchas Gracias
Authors: Pérez Benito Enrique 
Published: April 2020

A lo largo de las páginas de este trabajo hemos tratado de realizar un breve pero completo recorrido por la prensa cómico-erótica de entreguerras tomando como ejemplo uno de de sus principales exponentes: la revista Muchas Gracias. La perspectiva planteada es la de considerar este tipo de textos como una muestra absolutamente representativa de los parámetros nuevos por los que se movía la creación literaria tras la irrupción de las vanguardias y las convulsiones históricas de principios de siglo.
RESEÑA. Ana Calvo Revilla (ed.), Elogio de lo mínimo. Estudios sobre microrrelato y minificción en el siglo XXI, Madrid-Fráncfort, Iberoamericana-Vervuert, 2018, 314 pp.
Authors: González Pascual Guillermo González 
Published: April 2020

Reseña del libro: Ana Calvo Revilla (ed.), Elogio de lo mínimo. Estudios sobre microrrelato y minificción en el siglo XXI, Madrid-Frankfurt, Iberoamericana-Vervuert, 2018, 314 pp. ISBN: 978-8416-922581.