bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable Catalytic Synthesis for a Bio‐Based Alternative to the Reach‐Restricted N‐Methyl‐2‐Pyrrolidone
Authors: Barbaro Pierluigi , Liguori Francesca , Oldani Claudio , Moreno‐Marrodán Carmen 
Published: February 2020

AbstractThe catalytic conversion of biomass and its derivatives into valuable chemicals requires efficient, energy saving, and sustainable technologies. In this work, a variety of bifunctional catalysts are prepared combining immobilized metal nanoparticles and acid solid materials featuring Lewis or Brønsted acidity. The catalytic systems are tested in the reductive amination of bio‐derived levulinates with primary amines, using hydrogen as clean reducing agent, to obtain N‐substituted‐5‐methyl‐2‐pyrrolidones, which are proposed as substitutes for the widely used, REACH‐restricted solvent N‐methyl‐2‐pyrrolidone. The overall process is studied in depth to identify the best combination of metal and acid functionalities to be used in one‐pot and one stage. Pt immobilized onto the Brønsted solid acid Aquivion is shown to be the most efficient catalyst, with a productivity of N‐heptyl‐5‐methyl‐2‐pyrrolidone of 7.9 mmolgcat−1 h−1 reached at full conversion and 98.6% selectivity, under 120 °C, 4 bar H2 pressure and solvent‐free conditions.
EBV‐positive diffuse large B‐cell lymphoma, not otherwise specified: 2020 update on diagnosis, risk‐stratification and management
Authors: Beltran Brady E. , Castro Denisse , Paredes Sally , Miranda Roberto N. , Castillo Jorge J. 
Published: February 2020

AbstractDisease OverviewEpstein Barr virus‐positive (EBV+) diffuse large B‐cell lymphoma (DLBCL), not otherwise specified (NOS) is an entity included in the 2016 WHO classification of lymphoid neoplasms. EBV+ DLBCL, NOS, is an aggressive B‐cell lymphoma associated with chronic EBV infection, and a poor prognosis with standard chemotherapeutic approaches.DiagnosisThe diagnosis is made through a careful pathological evaluation. Detection of EBV‐encoded RNA (EBER) is considered standard for diagnosis; however, a clear cutoff for positivity has not been defined. The differential diagnosis includes plasmablastic lymphoma (PBL), DLBCL associated with chronic inflammation and primary effusion lymphoma (PEL), among others.Risk‐StratificationThe International Prognostic Index (IPI) and the Oyama score can be used for risk‐stratification. The Oyama score includes age >70 years and presence of B symptoms. The expression of CD30 and PD‐1/PD‐L1 are emerging as potential adverse but targetable biomarkers.ManagementPatients with EBV+ DLBCL, NOS, should be staged and managed following similar guidelines than patients with EBV‐negative DLBCL. EBV+ DLBCL, NOS, however, might have a worse prognosis than EBV‐negative DLBCL in the era of chemoimmunotherapy. There is an opportunity to study and develop targeted therapy in the management of patients with EBV+ DLBCL, NOS.
Dual‐Phase Thermally Activated Delayed Fluorescence Luminogens: A Material for Time‐Resolved Imaging Independent of Probe Pretreatment and Probe Concentration
Authors: Li Xuping , Baryshnikov Gleb , Ding Longjiang , Bao Xiaoyan , Li Xin , Lu Jianjun , Liu Miaoqing , Shen Shen , Luo Mengkai , Zhang Man , Ågren Hans , Wang Xudong , Zhu Liangliang 
Published: February 2020

AbstractDeveloping luminescent probes with long lifetime and high emission efficiency is essential for time‐resolved imaging. However, the practical applications usually suffer from emission quenching of traditional luminogens in aggregated states, or from weak emission of aggregation‐induced emission type luminogens in monomeric states. Herein, we overcome this dilemma by a rigid‐and‐flexible alternation design in donor–acceptor–donor skeletons, to achieve a thermally activated delayed fluorescence luminogen with high emission efficiency both in the monomeric state (quantum yield up to 35.3 %) and in the aggregated state (quantum yield up to 30.8 %). Such a dual‐phase strong and long‐lived emission allows a time‐resolved luminescence imaging, with an efficiency independent of probe pretreatment and probe concentration. The findings open opportunities for developing luminescent probes with a usage in larger temporal and spatial scales.
Evaluation of additively manufactured ultraperformance polymers to use as thermal protection systems for spacecraft
Authors: Kafi Abdullah , Wu Hao , Langston Jon , Atak Ozen , Kim Haewon , Kim Steven , Fahy William P. , Reber Roderick , Misasi John , Bateman Stuart , Koo Joseph H. 
Published: February 2020

AbstractIn this study, high‐temperature thermoplastic polymers were three‐dimensional (3D) printed and evaluated for ablation performances for the first time. The purpose of this study is to fabricate, test, and evaluate several ultraperformance thermoplastics, including polyetherimide (PEI), polyether ether ketone (PEEK), and poly(ether ketone ketone) (PEKK) for thermal, flammability, and ablation properties using fused filament fabrication. Among all tested materials, PEKK exhibit the highest char yield while the two PEEKs exhibit the highest decomposition temperature. Although PEI have the lowest onset decomposition temperature, microscale combustion calorimetry results indicate that it has the lowest heat release properties. For the 15 s oxyacetylene test bed (OTB) ablation test, all five materials experienced various amount of intumescent or swelling behavior. Samples after 30 s test experienced greater mass loss among which PEKK and ULTEM 9085 shows the highest char yield. Scanning electron microscopy microstructural analysis of the char and pyrolysis zones reveal highly porous char structures caused by the rapid generation of the volatile decomposition products. To fully exploit the experimental data provided by the OTB, the flowfield generated during aerothermal testing using this heat source was modeled. Computational fluid dynamics analysis using Ansys/Fluent 19.1 code was used to the heat transfer between the ablative surface and the combustion gases generated by the OTB and compared with experimental results.
Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients
Authors: Martin-Fernandez M , Vaquero-Roncero L M , Almansa R , Gómez-Sánchez E , Martín S , Tamayo E , Esteban-Velasco M C , Ruiz-Granado P , Aragón M , Calvo D , Rico-Feijoo J , Ortega A , Gómez-Pesquera E , Lorenzo-López M , López J , Doncel C , González-Sanchez C , Álvarez D , Zarca E , Ríos-Llorente A , Diaz-Alvarez A , Sanchez-Barrado E , Andaluz-Ojeda D , Calvo-Vecino J M , Muñoz-Bellvís L , Gomez-Herreras J I , Abad-Molina C , Bermejo-Martin J F , Aldecoa C , Heredia-Rodríguez M 
Published: February 2020

AbstractBackgroundStratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients.MethodsLevels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals.ResultsThere were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P &lt; 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P &lt; 0·001).ConclusionMR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection.
A TREML2 missense variant influences specific hippocampal subfield volumes in cognitively normal elderly subjects
Authors: Wang Si‐Yu , Xue Xiao , Duan Rui , Gong Peng‐Yu , E Yan , Jiang Teng , Zhang Ying‐Dong ,   For the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2020

AbstractIntroductionTriggering receptor expressed on myeloid cells‐like transcript 2 gene (TREML2) is a newly identified AD susceptibility gene. Its missense variant rs3747742‐C substantially decreases AD risk in both Caucasians and Han Chinese, but the underlying mechanisms remain elusive. In the present study, to uncover the possible mechanisms by which TREML2 rs3747742‐C reduces AD risk, we investigated the possible relation of this variant with AD‐related brain structures using a cognitively normal elderly population from Alzheimer's Disease Neuroimaging Initiative (ADNI) database.MethodsIn total, 158 cognitively normal elders from ADNI database with complete data for brain structures and TREML2 rs3747742 genotype were included in this study. The association of TREML2 rs3747742 genotype with the structures of three cerebral cortices (entorhinal cortex, middle temporal gyrus, and parahippocampal gyrus), two subcortical regions (amygdala and hippocampus), and three subfields of hippocampus (CA1, CA2 + CA3, and CA4 + dentate gyrus) was investigated.ResultsA significant difference was noted in the volume of right CA1 subfield among three genotypes of TREML2 rs3747742 (p = .0364). In the multivariate analysis, TREML2 rs3747742‐C significantly increased right CA1 subfield volume after adjusting for age, gender, education years, APOE ε4 status, and intracranial volume under the recessive genetic model (Bonferroni corrected p = .003586).ConclusionThe present study provides the first evidence that TREML2 rs3747742‐C carriers have larger volumes of hippocampal CA1 subfield in a cognitively normal elderly population. These findings imply that enhancement of brain reserve may contribute to the protection of TREML2 rs3747742‐C in AD susceptibility.
Evidence of pseudoprogression in patients treated with PD1/PDL1 antibodies across tumor types
Authors: Martin‐Romano Patricia , Castanon Eduardo , Ammari Samy , Champiat Stéphane , Hollebecque Antoine , Postel‐Vinay Sophie , Baldini Capucine , Varga Andrea , Michot Jean Marie , Vuagnat Perrine , Marabelle Aurélien , Soria Jean‐Charles , Ferté Charles , Massard Christophe 
Published: February 2020

AbstractBackgroundPD(L)1 antibodies (anti‐PD(L)‐1) have been a major breakthrough in several types of cancer. Novel patterns of response and progression have been described with anti‐PD(L)‐1. We aimed at characterizing pseudoprogression (PSPD) among patients with various solid tumor types treated by anti‐PD(L)‐1.MethodsAll consecutive patients (pts) enrolled in phase 1 trials with advanced solid tumors and lymphomas treated in phase I clinical trials evaluating monotherapy by anti‐PD(L)‐1 at Gustave Roussy were analyzed. We aimed to assess prevalence and outcome of PSPD across tumor types. We also intended to describe potential clinical and pathological factors associated with PSPD.ResultsA total of 169 patients treated with anti‐PD(L)‐1 were included in the study. Most frequent tumor types included melanoma (n = 57) and non‐small cell lung cancer (n = 19). At first tumor evaluation 77 patients (46%) presented with immune unconfirmed progressive disease. Six patients (8%) experienced PSPD: 2 patients with partial response; 4 patients with stable disease. Increase in target lesions in the first CT‐scan was more frequently associated to PSPD (67% vs 33%; P = .04). Patients with a PSPD had a superior survival when compared to patients progressing (median OS: 10.7 months vs 8.7 months; P = .07).ConclusionsA small subset of PSPD patients may experience response after an initial progression. Assessment of the current strategy for immune‐related response evaluations may require further attention.
The Reverse Palatal Pedicle Graft for Maxillary Molar Palatal Recessions: Two Case Reports
Authors: Weinstein Bradley F. , Pham Charles M. , Nguyen Thomas T. 
Published: February 2020

IntroductionHistorically, the treatment of palatal recession was thought to be extremely challenging if not impossible due to the anatomy of the palate. A novel technique is presented for treating gingival recession on maxillary molars utilizing a rotated subepithelial connective tissue pedicle graft. The technique is designed to maximize perfusion to the graft as compared to a free graftCase PresentationsThe authors present two cases in which the technique was utilized to achieve attachment gain and root coverage. The cases were followed for at least 2 months.ConclusionsMore than 5 mm of attachment was gained and 55% to 60% root coverage achieved over recession defects on maxillary first molars. The following case reports demonstrate that the Reverse Palatal Pedicle Graft (RPPG) technique was successful in improving root coverage over maxillary palatal recession defects.
Feeling or following? A field‐experiment comparing social norms‐based and emotions‐based motives encouraging pro‐environmental donations
Authors: Bergquist Magnus , Nyström Lina , Nilsson Andreas 
Published: February 2020

AbstractIn this study, we design and explore interventions encouraging pro‐environmental donations by testing social norms and anticipated positive emotions. The social norms‐based intervention included descriptive and injunctive social normative information while the emotions‐based intervention included information about anticipated positive emotions. The two intervention techniques were tested in a field‐experiment; applying social norms‐based or emotions‐based messages to a real choice situation between retaining versus donating one's own money (i.e., using recycling machines giving people the choice to either retain money obtained from their recycled bottles, or to donate their money to a pro‐environmental organization). Results showed that more people donated their money after being exposed to the emotions‐based message, than the social norms‐based message or no message.
Fundamental Aspects of Xanthene Dye Aggregation on the Surfaces of Nanocluster Polyoxometalates: H‐ to J‐Aggregate Switching
Authors: Fazylova Victoria , Shevtsev Nikita , Mikhailov Sergey , Kim Grigoriy , Ostroushko Alexander , Grzhegorzhevskii Kirill 
Published: February 2020

AbstractThe induced aggregation of the xanthene dye rhodamine B (RhB) on metal oxide centers belonging to the highly symmetric surfaces of precise nanoscale templates with Keplerate (Mo132) or toroidal (Mo138) structures has been studied. With the joint use of the Langmuir isotherm and full Stern–Volmer models, the thermodynamic reasons for dye adsorption on the nanocluster surface, such as a mixture of monomer, H‐aggregate (H‐dimer), and J‐aggregate forms (which can coexist or switch one into another under the exact conditions), were established: this was shown through UV/Vis and fluorescence spectroscopies. By using the framework of the exciton model, it is shown that the angle (α) between the transition dipole moments of RhB is very sensitive to surface strain inside the dye sub‐monolayer. As a result, it is possible to switch from H‐ to J‐aggregates by the post‐functionalization of polyoxometalate (POM)‐RhB associates by the surfactant bilayer shell, which allows the surface strain to grow. Recommendations are provided for managing the appearance of H‐ or J‐aggregates on metal oxide (or polyelectrolyte) surfaces during photovoltaic or bioimaging applications.
Bromine‐Functionalized Covalent Organic Frameworks for Efficient Triboelectric Nanogenerator
Authors: Zhai Lipeng , Cui Siwen , Tong Boli , Chen Weihua , Wu Zijie , Soutis Constantinos , Jiang Donglin , Zhu Guangshan , Mi Liwei 
Published: February 2020

AbstractCovalent organic frameworks (COFs) enable precise integration of various organic building blocks into porous skeletons through topology predesign. Here, we report the first example of COFs by integrating electron withdrawing bromine group onto the skeletons for triboelectric nanogenerators (TENG). The resulting framework exhibits high surface area and good crystallinity. Thus, the bromine functionalized COF has more regular aligned π columns and arrays over the skeleton than bare COFs, which in turn significantly enhances charge transport ability. As a result, bromine functionalized COFs showed higher electrical output performance at 5 Hz with a peak value of short circuit current density of 43.6 μA and output voltage of 416 V, which is 2 and 1.3 times higher than those of bare COFs (21.6 μA and 318 V), respectively. These results demonstrated that this strategy for engineering electron withdrawing groups on the skeleton could open a new aspect of COFs for developing TENG devices.
Enhanced Electrosynthetic Hydrogen Evolution by Hydrogenases Embedded in a Redox‐Active Hydrogel
Authors: Ruth John C. , Milton Ross D. , Gu Wenyu , Spormann Alfred M. 
Published: February 2020

AbstractMolecular hydrogen is a major high‐energy carrier for future energy technologies, if produced from renewable electrical energy. Hydrogenase enzymes offer a pathway for bioelectrochemically producing hydrogen that is advantageous over traditional platforms for hydrogen production because of low overpotentials and ambient operating temperature and pressure. However, electron delivery from the electrode surface to the enzyme's active site is often rate‐limiting. Here, it is shown that three different hydrogenases from Clostridium pasteurianum and Methanococcus maripaludis, when immobilized at a cathode in a cobaltocene‐functionalized polyallylamine (Cc‐PAA) redox polymer, mediate rapid and efficient hydrogen evolution. Furthermore, it is shown that Cc‐PAA‐mediated hydrogenases can operate at high faradaic efficiency (80–100 %) and low apparent overpotential (−0.578 to −0.593 V vs. SHE). Specific activities of these hydrogenases in the electrosynthetic Cc‐PAA assay were comparable to their respective activities in traditional methyl viologen assays, indicating that Cc‐PAA mediates electron transfer at high rates, to most of the embedded enzymes.
The Impact of Leadership on Absorptive Capacity: New insights from the UAE
Authors: Rezaei Zadeh Mohammad , Haak‐Saheem Washika , Darwish Tamer K. , Singh Satwinder 
Published: February 2020

AbstractThis paper investigates the impact of transformational and transactional leadership on the absorptive capacity of firms within an emerging market setting. Unlike some findings from the Western world, the results indicate that both transformational and transactional leadership styles positively influence the learning processes of absorptive capacity. More specifically, the results indicate that transactional leadership style positively influences the exploratory and transformative learning processes, while the transformational leadership style positively affects the exploitative learning process. Given the unique context under investigation and the fluid institutional arrangements associated with it, the results reflect the need for leadership guidance. Implications for theory and practice are discussed.
Beta‐blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity rationale and study design of a prospective, randomized, controlled trial (The Preserve‐HR trial)
Authors: Palau Patricia , Seller Julia , Domínguez Eloy , Gómez Inés , Ramón José María , Sastre Clara , de la Espriella Rafael , Santas Enrique , Miñana Gema , Chorro Francisco J. , González‐Juanatey José Ramón , Núñez Julio 
Published: February 2020

AbstractBackgroundThe pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence (ChI) has emerged as a crucial pathophysiological mechanism. Beta‐blockers, drugs with negative chronotropic effects, are commonly used in HFpEF, although current evidence does not support its routine use in these patients.HypothesisWe postulate beta‐blockers may have deleterious effects in HFpEF and ChI. This work aims to evaluate the short‐term effect of beta‐blockers withdrawal on functional capacity assessed by the maximal oxygen uptake (peakVO2) in patients with HFpEF and ChI.MethodsThis is a prospective, crossover, randomized (1:1) and multicenter study. After randomization, the clinical and cardiac rhythm will be continuously registered for 30 days. PeakVO2 is assessed by cardiopulmonary exercise testing (CPET) at 15 and 30 days in both groups. Secondary endpoints include quality of life, cognitive, and safety assessment. Patients with stable HFpEF, functional class New York Heart Association (NYHA) II‐III, chronic treatment with beta‐blockers, and ChI will be enrolled. A sample size estimation [alfa: 0.05, power: 90%, a 20% loss rate, and delta change of mean peakVO2: +1.2 mL/kg/min (SD ± 2.0)] of 52 patients is necessary to test our hypothesis.ResultsPatients started enrolling in October 2018. As January 14th, 2020, 28 patients have been enrolled. It is projected to enroll the last patient at the end of July 2020.ConclusionsOptimizing therapy that improves functional capacity remains an unmeet priority in HFpEF. Deprescribing beta‐blockers in patients with HFpEF and ChI seems a plausible intervention to improve functional capacity. This trial is an attempt towards precision medicine in this complex syndrome.Trial registrationClinicalTrials.gov: NCT03871803.
Synthesis and J‐Dimer Formation of Tetrapyrazinoporphyrazines with Different Functional Groups for Potential Biomolecular Probe Applications
Authors: Demuth Jiri , Miletin Miroslav , Machan Matej , Kantor Michal , Zimcik Petr , Novakova Veronika 
Published: February 2020

AbstractThough tetrapyrazinoporphyrazines (TPyzPzs) are generally presented as universal dark quenchers for oligonucleotide probes, the availability of TPyzPzs bearing different functional groups suitable for attachment to 3′, and 5′ ends or intrastrand positions remains rather limited. Therefore, a synthetic route to hexa(bis(2‐methoxyethyl)amino) or hexa(diethylamino) TPyzPzs functionalized by an azide, hydroxy, or carboxy group or their combinations was developed. Studies of self‐assembly into J‐dimers in nonpolar solvents and their stability upon titration with pyridine (association constants, KP values, ranging 0.32–12.7×102 M−1) revealed that smaller peripheral substituents and functionalization of TPyzPzs improves the stability of J‐dimers. ΦΔ and ΦF were low for the monomers (ΦF<0.0001, ΦΔ<0.008, DMF) due to quenching by intramolecular charge transfer; however, they increased in nonpolar solvents and after self‐assembly into J‐dimer (up to ΦF=0.027, ΦΔ=0.28).