bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Useful Is a Linear Ozone Parameterization for Global Climate Modeling?
Authors: Meraner Katharina , Rast Sebastian , Schmidt Hauke 
Published: March 2020

AbstractThe explicit calculation of stratospheric ozone in global climate models still comes at a high computational cost. Here, the usefulness of a linear ozone parameterization in a global climate model is assessed by comparing it to an explicit chemistry scheme and to observations. It is shown that the annual mean total ozone column and the tropical ozone profile agree well for the linear and the explicit chemistry schemes and the observations. Ozone variability caused by the quasi‐biennial oscillation and by extratropical quasi‐stationary planetary waves is reproduced qualitatively, but its magnitude is underestimated in particular in the simulations using the linear parameterization. The response of ozone to a quadrupling of CO
simulated with both schemes is in the range of earlier simulations with explicit schemes. This concerns in particular ozone decreases in the tropical lower stratosphere and increases above predicted as a consequence of a strengthening of tropical upwelling and potentially affecting climate sensitivity. This study demonstrates that despite existing weaknesses a linear ozone parameterization can be a useful tool to represent stratospheric ozone in climate models at negligible computational cost.
Appreciation of Peer Reviewers for 2019
Authors: Zhang Minghua , Giorgi Filippo , Leung Ruby , Mellouki Wahid , Randel William , Russell Lynn , Yang Ping , Zhang Chidong 
Published: March 2020

AbstractThe editors of Journal of Geophysical Research (JGR): Atmospheres wish to sincerely thank the 2,573 outstanding scientists who reviewed manuscripts for the journal in 2019. Peer review is a crucial process to ensure the integrity and rigor of science. Your reviews have helped to improve the qualities of research by many authors, stimulated new ideas, and impacted the careers of many young scientists. Through these reviews, you contributed not only to the high standard of JGR‐Atmospheres but also to the standing of our scientific discipline. Of the 2,573 reviewers listed below for the 1,757 new papers and 1,358 revised papers submitted to the journal (amounting to a total of 3,115 papers), 491 people reviewed three or more papers. On behalf of the journal, the authors, and the community, we thank all reviewers for your selfless service and dedication to the scientific community. We look forward to your continuing support!
The shape of a defense-growth trade-off governs seasonal trait dynamics in natural phytoplankton
Authors: Ehrlich Elias , Kath Nadja J , Gaedke Ursula 
Published: March 2020

Abstract
Theory predicts that trade-offs, quantifying costs of functional trait adjustments, crucially affect community trait adaptation to altered environmental conditions, but empirical verification is scarce. We evaluated trait dynamics (antipredator defense, maximum growth rate, and phosphate affinity) of a lake phytoplankton community in a seasonally changing environment, using literature trait data and 21 years of species-resolved high-frequency biomass measurements. The trait data indicated a concave defense-growth trade-off, promoting fast-growing species with intermediate defense. With seasonally increasing grazing pressure, the community shifted toward higher defense levels at the cost of lower growth rates along the trade-off curve, while phosphate affinity explained some deviations from it. We discuss how low fitness differences of species, inferred from model simulations, in concert with stabilizing mechanisms, e.g., arising from further trait dimensions, may lead to the observed phytoplankton diversity. In conclusion, quantifying trade-offs is key for predictions of community trait adaptation and biodiversity under environmental change.
Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis
Authors: Iwaszko Milena , Świerkot Jerzy , Dratwa Marta , Wysoczańska Barbara , Korman Lucyna , Bugaj Bartosz , Kolossa Katarzyna , Jeka Sławomir , Wiland Piotr , Bogunia-Kubik Katarzyna 
Published: March 2020

AbstractMHC class I polypeptide-related sequence A (MICA) is a stress-induced protein involved in activation of NK and T cells through interaction with NKG2D receptor. These molecules are atypically expressed in synovium of patients diagnosed with rheumatoid arthritis (RA). A total of 279 patients with RA, qualified to TNF-blockade therapy, were genotyped for MICA rs1051792 SNP. The effectiveness of anti-TNF agents was assessed with European League Against Rheumatism criteria. Significant relationship between MICA rs1051792 and outcome of TNF-blockade therapy has been found. The MICA rs1051792 GG genotype was overrepresented in patients non-responsive to anti-TNF drugs in comparison with other genotypes (p = 0.010). On the other hand, beneficial therapeutic response was more frequently detected among RA subjects possessing heterozygous genotype than those with homozygous genotypes (p = 0.003). Furthermore, increased MICA concentrations in serum were observed in patients possessing MICA rs1051792 GG genotype as compared with those with GA or AA genotypes (p = 1.8 × 10−5). The results from this study indicate the potential influence of MICA rs1051792 polymorphism on modulation of therapeutic response to TNF-blockade treatment in RA.
Plerixafor combined with standard regimens for hematopoietic stem cell mobilization in pediatric patients with solid tumors eligible for autologous transplants: two-arm phase I/II study (MOZAIC)
Authors: Morland Bruce , Kepak Tomas , Dallorso Sandro , Sevilla Julian , Murphy Dermot , Luksch Roberto , Yaniv Isaac , Bader Peter , Rößler Jochen , Bisogno Gianni , Maecker-Kolhoff Britta , Lang Peter , Zwaan C. Michel , Sumerauer David , Kriván Gergely , Bernard John , Liu Qianying , Doyle Eileen , Locatelli Franco 
Published: March 2020

AbstractThis study (NCT01288573) investigated plerixafor’s safety and efficacy in children with cancer. Stage 1 investigated the dosage, pharmacokinetics (PK), pharmacodynamics (PD), and safety of plerixafor + standard mobilization (G-CSF ± chemotherapy). The stage 2 primary endpoint was successful mobilization (doubling of peripheral blood CD34+ cell count in the 24 h prior to first apheresis) in patients treated with plerixafor + standard mobilization vs. standard mobilization alone. In stage 1, three patients per age group (2–<6, 6–<12, and 12–<18 years) were treated at each dose level (160, 240, and 320 µg/kg). Based on PK and PD data, the dose proposed for stage 2 was 240 µg/kg (patients 1–<18 years), in which 45 patients were enrolled (30 plerixafor arm, 15 standard arm). Patient demographics and characteristics were well balanced across treatment arms. More patients in the plerixafor arm (24/30, 80%) met the primary endpoint of successful mobilization than in the standard arm (4/14, 28.6%, p = 0.0019). Adverse events reported as related to study treatment were mild, and no new safety concerns were identified. Plerixafor + standard G-CSF ± chemotherapy mobilization was generally well tolerated and efficacious when used to mobilize CD34+ cells in pediatric cancer patients.
Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice
Authors: Nakano Yuki , Hirooka Kazuyuki , Chiba Yoichi , Ueno Masaki , Ojima Daiki , Hossain Md Razib , Takahashi Hiroo , Yamamoto Tohru , Kiuchi Yoshiaki 
Published: March 2020

AbstractMaintenance of retinal ganglion cells (RGCs) activity is relied on axonal transport conveying materials required for their survival such as neurotrophic factors. Kinesin-1 undergoes anterograde transport in axons, and Alcadein α (Alcα; also called calsyntenin-1) is a major cargo adaptor protein that can drive kinesin-1 to transport vesicles containing Alcα. The long-term effects of Alcα-deficiency on retinal morphology and survival of RGCs during postnatal development were examined in Alcα knockout mice. At 1.5, 3, 6, and 15 months postnatal, the number of retrogradely labeled RGCs was determined in flat-mounted retinas of Alcα-deficient and wild-type mice. Retinal damage was assessed histologically by determining the retinal thickness. Intraocular pressure (IOP) was measured with a Tonolab tonometer. At 1.5 months postnatal, the number of retrogradely labeled RGCs was not different between wild-type and Alcα-deficient mice. However, at 3, 6, and 15 months postnatal, the number of RGCs was significantly lower in Alcα deficient mice than those of wild-type mice (143 ± 41.1 cells/mm2 vs. 208 ± 28.4 cells/mm2, respectively, at 3 months; P < 0.01). No differences were seen in retinal thickness or IOP between the two types of mice at any postnatal age. Alcα-deficient mice showed spontaneous loss of RGCs but no elevation in IOP. These mice mimic normal-tension glaucoma and will be useful for investigating the mechanism of neurodegeneration in this disorder and for developing treatments for RGC loss that does not involve changes in IOP.
In situ atomic-scale observation of grain size and twin thickness effect limit in twin-structural nanocrystalline platinum
Authors: Wang Lihua , Du Kui , Yang Chengpeng , Teng Jiao , Fu Libo , Guo Yizhong , Zhang Ze , Han Xiaodong 
Published: March 2020

AbstractTwin-thickness-controlled plastic deformation mechanisms are well understood for submicron-sized twin-structural polycrystalline metals. However, for twin-structural nanocrystalline metals where both the grain size and twin thickness reach the nanometre scale, how these metals accommodate plastic deformation remains unclear. Here, we report an integrated grain size and twin thickness effect on the deformation mode of twin-structural nanocrystalline platinum. Above a ∼10 nm grain size, there is a critical value of twin thickness at which the full dislocation intersecting with the twin plane switches to a deformation mode that results in a partial dislocation parallel to the twin planes. This critical twin thickness value varies from ∼6 to 10 nm and is grain size-dependent. For grain sizes between ∼10 to 6 nm, only partial dislocation parallel to twin planes is observed. When the grain size falls below 6 nm, the plasticity switches to grain boundary-mediated plasticity, in contrast with previous studies, suggesting that the plasticity in twin-structural nanocrystalline metals is governed by partial dislocation activities.
An automatically curated first-principles database of ferroelectrics
Authors: Smidt Tess E. , Mack Stephanie A. , Reyes-Lillo Sebastian E. , Jain Anubhav , Neaton Jeffrey B. 
Published: March 2020

AbstractFerroelectric materials have technological applications in information storage and electronic devices. The ferroelectric polar phase can be controlled with external fields, chemical substitution and size-effects in bulk and ultrathin film form, providing a platform for future technologies and for exploratory research. In this work, we integrate spin-polarized density functional theory (DFT) calculations, crystal structure databases, symmetry tools, workflow software, and a custom analysis toolkit to build a library of known, previously-proposed, and newly-proposed ferroelectric materials. With our automated workflow, we screen over 67,000 candidate materials from the Materials Project database to generate a dataset of 255 ferroelectric candidates, and propose 126 new ferroelectric materials. We benchmark our results against experimental data and previous first-principles results. The data provided includes atomic structures, output files, and DFT values of band gaps, energies, and the spontaneous polarization for each ferroelectric candidate. We contribute our workflow and analysis code to the open-source python packages atomate and pymatgen so others can conduct analogous symmetry driven searches for ferroelectrics and related phenomena.
A comparative analysis of link removal strategies in real complex weighted networks
Authors: Bellingeri M. , Bevacqua D. , Scotognella F. , Alfieri R. , Cassi D. 
Published: March 2020

AbstractIn this report we offer the widest comparison of links removal (attack) strategies efficacy in impairing the robustness of six real-world complex weighted networks. We test eleven different link removal strategies by computing their impact on network robustness by means of using three different measures, i.e. the largest connected cluster (LCC), the efficiency (Eff) and the total flow (TF). We find that, in most of cases, the removal strategy based on the binary betweenness centrality of the links is the most efficient to disrupt the LCC. The link removal strategies based on binary-topological network features are less efficient in decreasing the weighted measures of the network robustness (e.g. Eff and TF). Removing highest weight links first is the best strategy to decrease the efficiency (Eff) in most of the networks. Last, we found that the removal of a very small fraction of links connecting higher strength nodes or of highest weight does not affect the LCC but it determines a rapid collapse of the network efficiency Eff and the total flow TF. This last outcome raises the importance of both to adopt weighted measures of network robustness and to focus the analyses on network response to few link removals.
Factors affecting ENSO predictability in a linear empirical model of tropical air-sea interactions
Authors: Rashid Harun A. 
Published: March 2020

AbstractUnderstanding and extending the predictability of El Niño‒Southern Oscillation (ENSO) has been an important research topic because of ENSO’s large influence on global weather and climate. Here, we develop an empirical model of tropical atmosphere-ocean interactions that has high ENSO prediction skill, comparable to the skills of well performing dynamical models. The model is used to investigate the effects of the main atmosphere-ocean interaction processes—thermocline and zonal wind feedbacks and zonal wind forcing—on its ENSO predictability. We find that all these processes significantly affect ENSO predictability and extend the predictability limit by up to four months, with the largest effect coming from the thermocline feedback followed by the total zonal wind forcing. The other processes with progressively smaller effects are the external zonal wind forcing and zonal wind feedback. The two most influential processes, however, affect ENSO predictability in the VAR model differently. The thermocline feedback improves the forecast skill by predominantly maintaining the correct phase, whereas the total zonal wind forcing improves the skill by maintaining the correct amplitude of the forecast ENSO events. This result suggests that the dynamical seasonal prediction models must have good representations of the major ENSO processes to make skilful ENSO predictions.
Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance
Authors: Roudnicky Filip , Kim Bo Kyoung , Lan Yanjun , Schmucki Roland , Küppers Verena , Christensen Klaus , Graf Martin , Patsch Christoph , Burcin Mark , Meyer Claas Aiko , Westenskow Peter D. , Cowan Chad A. 
Published: March 2020

AbstractEndothelial cells (ECs) display remarkable plasticity during development before becoming quiescent and functionally mature. EC maturation is directed by several known transcription factors (TFs), but the specific set of TFs responsible for promoting high-resistance barriers, such as the blood-brain barrier (BBB), have not yet been fully defined. Using expression mRNA data from published studies on ex vivo ECs from the central nervous system (CNS), we predicted TFs that induce high-resistance barrier properties of ECs as in the BBB. We used our previously established method to generate ECs from human pluripotent stem cells (hPSCs), and then we overexpressed the candidate TFs in hPSC-ECs and measured barrier resistance and integrity using electric cell-substrate impedance sensing, trans-endothelial electrical resistance and FITC-dextran permeability assays. SOX18 and TAL1 were the strongest EC barrier-inducing TFs, upregulating Wnt-related signaling and EC junctional gene expression, respectively, and downregulating EC proliferation-related genes. These TFs were combined with SOX7 and ETS1 that together effectively induced EC barrier resistance, decreased paracellular transport and increased protein expression of tight junctions and induce mRNA expression of several genes involved in the formation of EC barrier and transport. Our data shows identification of a transcriptional network that controls barrier resistance in ECs. Collectively this data may lead to novel approaches for generation of in vitro models of the BBB.
Performance of single-use syringe versus multi-use MR contrast injectors: a prospective comparative study
Authors: Struik F. , Futterer J. J. , Prokop W. M. 
Published: March 2020

AbstractThe goal of this study was to compare performance parameters of a single-use syringe and a multi-use MR contrast injector. We compared preparation time, cost for disposables and volumes of contrast material used for a single-use (SI) and a multi-use (MI) MR contrast injector in a prospective cross-over trial. During the first study period all consecutive patients eligible for dynamic MR on two systems were included during a period of 20 working days. After 10 days, the injector was switched. Radiographer satisfaction was evaluated using a questionnaire. Contrast usage and waste on system MI was optimised by extra instructions for our radiographers and measured during the second study period of 10 consecutive working days. A total of 202 and 163 patients for systems SI and MI were included, respectively. Average preparation time was 4:55 min for SI and 2:24 min for MI (p < 0.05). Contrast waste for SI was 13% using 7.5 ml syringes. Contrast waste for MI was 5% for 7.5 ml containers. Costs for disposables were lower for MI if more than 5 patients per day were injected. Radiographer satisfaction was higher for MI (4.7 versus 2.8 on a 5-point scale; p < 0.05). The multi-use MR contrast injector led to higher radiographer satisfaction, shorter preparation time, and lower cost if more than 5 patients were injected per day. In addition, cheaper contrast containers of 15 or 30 ml could be used for the first patients if more than 2 or more than 4 injections are performed per day, potentially leading to lower contrast waste.
Distribution of Candidatus Liberibacter species in Eastern Africa, and the First Report of Candidatus Liberibacter asiaticus in Kenya
Authors: Ajene Inusa J. , Khamis Fathiya M. , van Asch Barbara , Pietersen Gerhard , Seid Nurhussen , Rwomushana Ivan , Ombura Fidelis L. O. , Momanyi George , Finyange Pole , Rasowo Brenda A. , Tanga Chrysantus M. , Mohammed Samira , Ekesi Sunday 
Published: March 2020

AbstractHuanglongbing (HLB) is a serious disease of Citrus sp. worldwide. In Africa and the Mascarene Islands, a similar disease is known as African citrus greening (ACG) and is associated with the bacterium Candidatus Liberibacter africanus (Laf). In recent years, Candidatus Liberibacter asiaticus (Las) associated with the severe HLB has been reported in Ethiopia. Thus, we aimed to identify the Liberibacter species affecting citrus, the associated vectors in Eastern Africa and their ecological distribution. We assessed the presence of generic Liberibacter in symptomatic leaf samples by quantitative PCR. Subsequently, we sequenced the 50 S ribosomal protein L10 (rplJ) gene region in samples positive for Liberibacters and identified the species by comparison with public sequence data using phylogenetic reconstruction and genetic distances. We detected generic Liberibacter in 26%, 21% and 66% of plants tested from Uganda, Ethiopia and Kenya, respectively. The rplJ sequences revealed the most prevalent Liberibacters in Uganda and Ethiopia were LafCl (22%) and Las (17%), respectively. We detected Las in Kenya for the first time from three sites in the coastal region. Finally, we modelled the potential habitat suitability of Las in Eastern Africa using MaxEnt. The projection showed large areas of suitability for the pathogen in the three countries surveyed. Moreover, the potential distribution in Eastern Africa covered important citrus-producing parts of Ethiopia, Kenya, Uganda and Tanzania, and included regions where the disease has not been reported. These findings will guide in the development of an integrated pest management strategy to ACG/HLB management in Africa.
Leachate effects of pelagic Sargassum spp. on larval swimming behavior of the coral Acropora palmata
Authors: Antonio-Martínez Francisco , Henaut Yann , Vega-Zepeda Alejandro , Cerón-Flores Ana I. , Raigoza-Figueras Rodolfo , Cetz-Navarro Neidy P. , Espinoza-Avalos Julio 
Published: March 2020

AbstractAn emerging disturbance for Caribbean reefs is the massive arrival of pelagic Sargassum, which deteriorates water quality due to the production of leachates. The highest arrivals of Sargassum took place when broadcasting corals spawned. We experimentally determined the effect of Sargassum leachates on swimming behavior of Acropora palmata larvae through five treatments (control, stain (simulating 100% leachate color), and 25%, 50% and 100% Sargassum leachate concentrations) during 30 min (10 min of videos and 20 min of post-observations). In the videos, larvae with leachates reduced swimming speed, were positively geotactic, the percentage of individuals that swam in a spiral pattern increased, and most behavioral displacements occurred at lower frequencies than larvae without leachates. Moreover, symptomatic spiral behavior was higher in the presence of leachates, suggesting that this behavior may be an effect of pollution. During post-observations, most larvae with leachates were motionless. This is the first time that Sargassum leachates have been documented modifying larval swimming behavior, which may reduce larval dispersion and genetic diversity. We suggest that a future evaluation of the effects of leachates at lower concentrations and over longer periods of exposure is needed. The resilience of corals may be compromised if Sargassum arrivals become frequent events.
Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer’s Disease Mouse during Reward-Oriented Drinking Test under Thirsty Conditions
Authors: Sakurai Keisuke , Shintani Teppei , Jomura Naohiro , Matsuda Takeshi , Sumiyoshi Akira , Hisatsune Tatsuhiro 
Published: March 2020

AbstractAlzheimer’s disease (AD), a neurodegenerative disease, causes behavioural abnormalities such as disinhibition, impulsivity, and hyperphagia. Preclinical studies using AD model mice have investigated these phenotypes by measuring brain activity in awake, behaving mice. In this study, we monitored the behavioural alterations of impulsivity and hyperphagia in middle-aged AD model mice. As a behavioural readout, we trained the mice to accept a water-reward under thirsty conditions. To analyse brain activity, we developed a measure for licking behaviour combined with visualisation of whole brain activity using awake fMRI. In a water-reward learning task, the AD model mice showed significant hyperactivity of the dorsal raphe nucleus in thirsty conditions. In summary, we successfully visualised altered brain activity in AD model mice during reward-oriented behaviour for the first time using awake fMRI. This may help in understanding the causes of behavioural alterations in AD patients.