bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Human Umbilical Cord-Derived Stem Cell and Hyperbaric Oxygen Therapy Effectively Preserved the Neurological Function and Brain Architecture in Rat After Acute Intracerebral Hemorrhage
Authors: Yip Hon-Kan , Lin Kun-Chen , Sung Pei-Hsun , Chiang John Y. , Yin Tsung-Cheng , Wu Re-Wen , Chen Kuan-Hung 
Published: September 2020

Abstract
Background: This study tested the hypothesis that combined therapy with human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) and hyperbaric oxygen (HBO) was superior to either one on preserving neurological function and reducing brain-hemorrhagic volume (BHV) in rat after acute intracerebral hemorrhage (ICH) induced by intracranial injection of collagenase. Methods and Results: Adult-male SD rats (n=30) were equally divided into group 1 (sham-operated control), group 2 (ICH), group 3 (ICH + HUCDMSCs/1.2x106 cells/intravenous injection at 3h and days 1/2 after ICH), group 4 (ICH + HBO/at 3h and days 1/2 after ICH) and group 5 (ICH + HUCDMSCs-HBO), and euthanized by day 28 after ICH. By day 1, the neurological function was significantly impaired in groups 2 to 5 than in group 1 (p<0.001), but it did not differ among groups 2 to 5. By days 7/4/28, the integrity of neurological function was highest in group 1, lowest in group 2 and significantly progressively improved from groups 3 to 5 (all p<0.001). By day 28, the BHV was lowest in group 1, highest in group 2 and significantly lower in group 5 than in groups 3/4 (all p<0.0001). The protein expressions of inflammation (HMGB1/TLR-2/TLR-4/MyD88/TRAF6/p-NF-κB/IFN-γ/IL-1ß/TNF-α), oxidative-stress/autophagy (NOX-1/NOX-2/oxidized protein/ratio of LC3BII/LC3BI) and apoptosis (cleaved-capspase3/PARP), and cellular expressions of inflammation (CD14+, F4/80+) in brain tissues exhibited an identical pattern, whereas cellular levels of angiogenesis (CD31+/vWF+/small-vessel number) and number of neurons (NeuN+) exhibited an opposite pattern of BHV among the groups (all p<0.0001). Conclusion: combined HUCDMSC-HBO therapy offered better outcomes after rat ICH.
A NOTCH1/LSD1/BMP2 Co-Regulatory Network Mediated by miR-137 Negatively Regulates Osteogenesis of Human Adipose-Derived Stem Cells
Authors: Fan Cong , Ma Xiaohan , Wang Yuejun , Lv Longwei , Zhu Yuan , Liu Hao , Liu Yunsong 
Published: September 2020

Abstract
Background: MicroRNAs have been recognized as critical regulators for the osteoblastic lineage differentiation of human adipose-derived stem cells (hASCs). Previously, we have displayed that silencing of miR-137 enhances the osteoblastic differentiation potential of hASCs partly through the coordination of lysine-specific histone demethylase 1 (LSD1), bone morphogenetic protein 2 (BMP2), and mothers against decapentaplegic homolog 4 (SMAD4). However, still numerous molecules involved in the osteogenic regulation of miR-137 remain unknown. This study aimed to further elucidate the epigenetic mechanisms of miR-137 on the osteogenic differentiation of hASCs.Methods: hASCs transfected with miR-137 overexpression or knockdown lentiviruses were used to assess the osteogenic capacity by testing the alkaline phosphatase activity, matrix mineralization degree, relative expression level of osteogenesis-associated genes and ectopic osteogenesis in nude mice. Dual-luciferase reporter assay was performed to examine the targeting of the 3' untranslated region (3' UTR) of NOTCH1 by miR-137. Interrelationships of signaling pathways of NOTCH1-hairy and enhancer of split 1 (HES1), LSD1, and BMP2-SMAD4 were thoroughly investigated by separate knockdown of NOTCH1, LSD1, and BMP2.Results: We confirmed that miR-137 directly targeted the 3' UTR of NOTCH1 while positively regulated HES1. After knocking down NOTCH1 or BMP2 individually, we found that these two signals formed a positive feedback loop and activated LSD1. In addition, LSD1 knockdown induced the expression of NOTCH1 while suppressed HES1.Conclusions: Collectively, we proposed a NOTCH1/LSD1/BMP2 co-regulatory signaling network to elucidate the modulation of miR-137 on the osteoblastic differentiation of hASCs, thus providing mechanism-based rationale for miRNA-targeted therapy of bone defect.
Enhancing Innovation Speed through Trust: - A Case Study on Reframing&nbsp;Employee Defensive Routines
Authors: Mitcheltree Christina Marie 
Published: September 2020

Abstract
Trust in organizations plays an essential role for efficient innovation implementation. However, trust between managers and employees is under communicated in relation to innovation speed. Innovation speed is related to innovation adoption, concerning new ways of performing laboratory services within the health sector. The purpose of this case study is to investigate how trust mechanisms may enhance innovation speed by reducing employee decisions to perform defensive routines. The focus is related to trust as a social condition for enhancing innovation acceptance in the context of management and organizing styles subject to the Norwegian working life model. The study found that a lack of employee participation and involvement, may result in emotional tension, a sense of uncertainty, disconnect, and various defensive mechanisms towards management and the innovation. Consequently, employees’ attention, loyalty and responsibility might be redirected away from the innovation.
Contribution of syndecans to the cellular entry of SARS-CoV-2
Authors: Hudák Anett , Szilák László , Letoha Tamás 
Published: September 2020

Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel emerging pathogen causing an unprecedented pandemic in 21st century medicine. Due to the significant health and economic burden of the current SARS-CoV-2 outbreak, there is a huge unmet medical need for novel interventions effectively blocking SARS-CoV-2 infection. Unknown details of SARS-CoV-2 cellular biology significantly hamper the development of potent and highly specific SARS-CoV-2 therapeutics. Angiotensin-converting enzyme-2 (ACE2) has been reported to be the primary receptor for SARS-CoV-2 cellular entry. However, emerging scientific evidence suggests the involvement of additional membrane proteins, such as heparan sulfate proteoglycans, in SARS-CoV-2 internalization. Here we report that syndecans, the evolutionarily conserved family of transmembrane proteoglycans facilitate the cellular entry of SARS-CoV-2. Among syndecans, syndecan-4 was the most efficient in mediating SARS-CoV-2 uptake, yet overexpression of other isoforms, including the neuronal syndecan-3, also increased SARS-CoV-2 internalization. The S1 subunit of the SARS-CoV-2 spike protein plays a dominant role in the virus’s interactions with syndecans. Besides the polyanionic heparan sulfate chains - the established binding sites for several viruses - other parts of the syndecan ectodomain, such as the cell-binding domain, also contribute to the interaction with SARS-CoV-2. During virus internalization, syndecans colocalize with ACE2, suggesting a jointly shared internalization pathway. Both ACE2 and syndecan inhibitors exhibited significant efficacy in reducing cellular entry of SARS-CoV-2, thus supporting the complex nature of internalization. Among these inhibitors, a peptide compromising the spike protein’s heparin-binding PRRAR motif significantly reduced SARS-CoV-2 cellular uptake, highlighting the need to go beyond the ACE2 paradigm for developing efficient therapeutics against SARS-CoV-2. Data obtained on syndecan specific in vitro assays present syndecans as novel cellular targets of SARS-CoV-2 and offers molecularly precise, yet simple strategies in overcoming the complex nature of SARS-CoV-2 infection.
It’s Not the Flu: Popular perceptions of the impact of COVID-19
Authors: Niemi Laura , Kniffin Kevin , Doris John M. 
Published: September 2020

Abstract
Messaging from authorities about COVID-19 has been widely divergent. This research aims to clarify popular perceptions of the threat of COVID-19 and its effects on victims. In four studies with over 4,100 U.S. participants, we consistently found that people perceive the threat of COVID-19 to be substantially greater than that of several other causes of death to which it has recently been compared, including the seasonal flu and automobile accidents. Participants were less willing to help COVID-19 victims, who they considered riskier to help, more contaminated, and more responsible for their condition. Additionally, politics and demographic factors predicted attitudes about victims of COVID-19 above and beyond moral values; whereas attitudes about the other kinds of victims were primarily predicted by moral values. The results indicate that people perceive COVID-19 as an exceptionally severe disease threat, and despite prosocial inclinations, do not feel safe offering assistance to COVID-19 sufferers.
Effect of an antiviral drug control in host COVID-19 kinetics
Authors: CHATTERJEE AMAR NATH , MONDAL JAYANTA , SAMUI PIU 
Published: September 2020

Abstract
The article proposes and analyzes a system of diﬀerential equations modeling the interaction of the SARS-CoV-2 virus and the epithelial cells of the human lungs. Optimal control strategies representing antiviral drug treatment eﬀects of this model are explored here. The Pontryagin’s max-imum principle is used to clarify the optimal control strategies. The exis-tence of optimal control is proved and eﬀective strategies are illustrated. Numerical simulations, eﬃciency analysis, and cost-eﬀectiveness analysis reveal that time-dependent antiviral drug with other control mechanisms, would reduce the viral load and control the infection process at low cost.
Neurological Outcome of Chest Compression-Only Bystander CPR in Asphyxial and Non-Asphyxial Out-of-Hospital Cardiac Arrest: An Observational Study
Authors: Javaudin François , Raiffort Julien , Desce Natacha , Baert Valentine , Hubert Hervé , Montassier Emmanuel , Cornec Clément Le , Lascarrou Jean-Baptiste , Bastard Quentin Le 
Published: September 2020

Abstract
Background: According to guidelines and bystander skill, two different methods of cardiopulmonary resuscitation (CPR) are feasible: standard CPR (S-CPR) with mouth-to-mouth ventilations and chest compression-only CPR (CO-CPR) without rescue breathing. CO-CPR appears to be most effective for cardiac causes, but there is a lack of evidence for asphyxial causes of out-of-hospital cardiac arrest (OHCA). Thus, the aim of our study was to compare CO-CPR versus S-CPR in adult OHCA from medical etiologies and assess neurologic outcome in asphyxial and non-asphyxial causes.Methods: Using the French National OHCA Registry (RéAC), we performed a multicenter retrospective study over a five-year period (2013 to 2017). All adult-witnessed OHCA who had benefited from either S-CPR or CO-CPR by bystanders were included. Non-medical causes as well as professional rescuers as witnesses were excluded. The primary end point was 30-day neurological outcome in a weighted population for all medical causes, and then for asphyxial, non-asphyxial and cardiac causes. Results: Of the 8 619 subjects included for all medical causes, 6 742 had a non-asphyxial etiology, including 5 904 of cardiac causes, and 1 710 had an asphyxial OHCA. 8.6%; 95% CI [8.1-9.3] of subjects had a good neurological outcome (i.e. cerebral performance category of 1 or 2). Bystanders who performed S-CPR began more often immediately (89.0%; 95% CI [87.3-90.5] versus 78.2%; 95% CI [77.2-79.2]) and in younger subjects (64.1 years versus 65.7; p < 0.001). In the weighted population, subjects receiving bystander-initiated CO-CPR had an adjusted relative risk (aRR) of 1.04; 95% CI [0.79-1.38] of having a good neurological outcome at 30 days for all medical causes, 1.28; 95% CI [0.92-1.77] for asphyxial etiologies, 1.08; 95% CI [0.80-1.46] for non-asphyxial etiologies and 1.09; 95% CI [0.93-1.28] for cardiac-related OHCA.Conclusions: We observed no significant difference in neurological outcome when lay bystanders of OHCA initiated CO-CPR or S-CPR, whether the cause was asphyxial or not. CO-CPR should probably be promoted in adults because it has many advantages (easier to learn and lower infection risk).
Konsep Ilmu Dan Pendidikan Dalam Persfektif Surat Al-Mujadilah Ayat 11
Authors: Fahrudin Ahmad , Fauziah Arbaul 
Published: September 2020

Abstract
Education is one of the main things that can make a significant contribution to the development and progress of a nation. This fact is evidenced by the existence of a generation of people who are quality-produced from educational institutions in Indonesia, if the young generation of this nation does not attend education, perhaps the development and progress of the times will not be able to be like today. Education, especially in Muslims, one of the foundations and guidelines for which is the Koran, through some of the verses it contains, there are some instructions and knowledge that are very extraordinary if we dig into the meaning for the meaning. So it is important for Muslims to make Al-Qur'an as a guide in processing their studies. Education and knowledge are two main things that are interrelated, they are like two sides of a coin that cannot be separated, even always in pairs. In the context of this article, the concept of knowledge and education from the perspective of the Koran will be discussed, namely taking one of the verses in Surah al-Mujadilah, verse 11. The verse explains the various things it contains, then explains Asbabun Nuzul, describes the verse, Menafsiri is then analyzed, hopefully, what is discussed here becomes a study that can increase wealth, both theoretical wealth and scientific wealth practically.
Keywords: Science, Education, Al-Mujadilah.

Abstrak
Pendidikan merupakan salah satu perkara pokok yang mampu memberikan kontribusi signifikan terhadap perkembangan dan kemajuan suatu bangsa. Fakta ini dibuktikan dengan adanya generasi bangsa yang secara kualitas dihasilkan dari bangku lembaga pendidikan yang ada di Indonesia, jika generasi muda bangsa ini tidak mengenyam bangku pendidikan, mungkin perkembangan dan kemajuan zaman tidak mampu seperti sekarang ini. Pendidikan khususnya dalam umat Muslim, salah satu landasan dan yang menjadi pedomannya adalah al-Qur’an, melalui beberapa ayat yang dikandungnya, terdapat beberapa petunjuk dan ilmu yang sangat luar jika diselami makna demi maknanya. Maka menjadi penting bagi umat Muslim menjadikan al-Qur’an sebagai pegangan dalam berproses di dalam menuntut ilmu. Pendidikan dan ilmu merupakan dua hal pokok yang berkaitkelindan, keduanya ibarat dua sisi mata uang logam yang tak mampu dipisahkan, bahkan selalu berpasangan. Dalam konteks artikel ini, maka akan di bahas kosep ilmu dan pendidikan dari persfektif al-Qur’an, yaitu mengambil salah satu ayatnya dalam surat al-Mujadilah ayat 11. Ayat tersebut dijelaskan berbagai hal yang dikandungnya, kemudian dijelaskan asbabun nuzul, mendeskripsikan ayat, menafsiri kemudian dianalisis, semoga apa yang dibahas di sini menjadi sesuatu kajian yang mampu menambah kekayaan, baik kekayaan secara teoritis maupun kekayaan keilmuan secara praktis.
Kata Kunci: Ilmu, Pendidikan, Al-Mujadilah.
Osteopontin is a prognostic factor in patients with advanced gastric cancer
Authors: Yazici Ozan , Dogan Mutlu , Ozal Guze , Aktas Sedef Hande , Demirkazik Ahmet , Utkan Gungor , Senler Filiz Cay , Icli Fikri , Akbulut Hakan 
Published: September 2020

Objective:
Osteopontin (OPN), a phosphorylated sialoprotein, has been shown to overexpress in a variety of cancers and to contribute tumor progression and metastasis by increasing cell migration and adhesion. In the current study, we
aimed to investigate the prognostic and predictive role of OPN in patients with advanced gastric cancer.

Methods:
A total of 42 consecutive chemonaive patients with advanced gastric cancer and 29 healthy controls were included. The patients were treated with a modified DCF regimen. The blood samples were obtained before each chemotherapy
cycle from the patients and once from the healthy controls. The plasma OPN measured by ELISA.

Results:
The overall response and disease stabilization rates were 25% and 72%, respectively. The median serum OPN level of the patient group was significantly higher compared to healthy controls (176.9 ng/ml (range: 41.5 -521.4) vs 64.3
ng/ml (range 42.1-105.3 ng/ml), p<0.0001).The median overall survival time was 7.0 ± 1.1 (95% CI: 4.9–9.2) months and 1-
year overall survival rate was %20.8. The patients who respond to mDCF had lower plasma OPN levels than the nonresponder ones (110.7±29.3 ng/mL, 211.9±24.4 ng/mL respectively, p=0.002). The performance status and the plasma OPN
levels were found to be significant factors for overall survival in the multivariate analysis (p=0.004 and 0.016, respectively).

Conclusion:
The serum OPN seems to be a novel significant prognostic and predictive factor in patients with advanced
gastric cancer whom treated with DCF regimen.
EFFECTIVENESS OF MINDFULNESS-BASED COGNITIVE THERAPY (MBCT) TOWARDS DEPRESSION
Authors: Naibili Maria Julieta Esperanca , Permana Iman 
Published: September 2020

Depression is a common mental disorder that is leading cause of disability in the world by 2020 and a major contributor to overall global disease burden. Globally, more than 300 million people of all ages suffer from depression and more women. Depression can affect aspects of life including psychological, physical, and social. MBCT teaches patients through the mind, feelings, and body sensations to see an event temporarily without treating the event as an accurate reality. The aim of this study was to providing information about effectiveness of Â MBCT towards depression. The relevant health databases include PubMed, Science Direct, Garuda, Emerald Insight, EBSCO, Google Scholar, Google Search, ProQuest, searched using a combination of keywords: 'mindfulness-based cognitive therapy' and 'depression' and 'randomized controlled trial'. The result were The electronic search of the database identified 633 articles relating to MBCT. Furthermore, checking for duplicate and published articles, 620 criteria-filled studies, 128 full texts of 128 articles, 118 did not meet inclusion criteria for reasons not to investigate MBCT (n = 61), participants were not depressed / depressive disorder (n = 39) not a randomized controlled trial design (n = 14) published in letters, comments, editorials (n = 4). Then, the full text of the manuscripts included in the review amounted to 11 articles. In conclusion MBCT is an effective, acceptable, feasible, accessible, applicable form of mental health psychotherapy that aims to reduce symptoms of depression, anxiety, emotional distress and improve quality of life, improve social well-being, and improve psychological well-being.
Effects of xylitol impregnated toothbrushes on periodontal status and microbial flora in orthodontic patients
Authors: Koşar Selin , Çokakoğlu Serpil , Kaleli İlknur 
Published: September 2020

ABSTRACT

Objectives
To investigate whether the use of xylitol-impregnated toothbrushes affects periodontal condition and microbial flora in orthodontic patients with poor oral hygiene.

Materials and Methods
Forty-four patients with baseline mean Turesky plaque index scores ≥1.5 were randomly divided into two groups. Half received xylitol-containing toothbrushes and the other half, xylitol-free toothbrushes. The periodontal measurements and saliva samples were taken at baseline (T0), 1 month later (T1), and 3 months after brushing (T2) to evaluate periodontal health and microflora changes. Periodontal status was assessed with plaque index (PI), gingival index (GI), and bleeding on probing (BOP) scores. Data were statistically analyzed with Mann-Whitney U and Friedman tests.

Results
All periodontal parameters significantly decreased from T0 to T1 and from T0 to T2 in both groups. The PI and GI scores reduced significantly in the control group, while BOP scores reduced in both groups between T1 and T2. Intergroup comparisons showed significant differences for BOP, PI, and GI at T0, T1, and T2 times, respectively. For microbial parameters, there were no statistically significant differences within groups from T0 to T1. Total bacterial counts significantly decreased in the xylitol group between T1 and T2. Decreases in Streptococcus mutans and total bacteria were significant in both groups from T0 to T2. No significant differences were found between the groups in microbial flora at any time.

Conclusions
A 3-month use of xylitol-containing toothbrushes showed almost the same changes and provided no positive effects on periodontal and microbial parameters compared to the control group.
OPPORTUNITIES FOR PERSONALIZED EDUCATION SYSTEM IN FORMING OF PROFESSIONAL ORIENTATION FOR SECONDARY GENERAL SCHOOL
Authors: Мухаметова Ольга Анатольевна 
Published: September 2020

Исследуются вопросы проектирования профессионально ориентированной персонифицированной системы воспитания (ПСВ) в условиях основной общеобразовательной школы. Раскрывается тема формирования у старшеклассников профессионального самоопределения. Особое внимание обращается на включение семьи в процесс создания персонифицированной системы воспитания. Представлен опыт педагогического взаимодействия школы и семьи в становлении профессионального выбора у старшеклассников посредством построения профессионально ориентированной персонифицированной воспитательной системы. Проанализированы условия и возможности персонифицированной системы воспитания в профессиональной ориентации старшеклассников основной общеобразовательной школы.
The state and social order sets the school the task of forming a competitive, professionally mobile graduate on the labor market. This order is most definitely reflected in the Federal state educational standards of basic General education. The idea of forming an educational system is considered as an effective means of solving this problem. The possibilities of a new type of educational system focused on the development of a person as a person (hereinafter – PSЕ – personalized system of education) are investigated. This direction is implemented by an interregional research team led by E. N. Stepanov. This article deals with issues of constructing professional orientation system personalized education system (PSE) for secondary general school. The author looks into the idea of forming professional goals in upperclassmen. Special attention is given to the role of family in that process. Articles give specific examples of successful collaboration between the school system and the family in forming professional orientation in upperclassmen through the creation of personalized systems. The study was conducted to study the possibility and effectiveness of the use of PSV in the formation of readiness of high school students of the main secondary school for professional self-determination. The conditions and opportunities of the personalized system of education in the professional orientation of classmen of the main secondary school are analyzed.
Masculinidades y feminidades en la música metal
Authors: Calvo Manuela Belén 
Published: September 2020

En el artículo se desarrolla parte de los resultados de investigación acerca de la escena bonaerense de la música metal entre los años 2013 y 2017. El eje está puesto en la perspectiva de género y en las sexualidades. La escena construye una identidad social predominante a través del paradigma de la autenticidad metálica, que se caracteriza por evaluar la veracidad de les músiques, les aficionades y sus prácticas por medio de parámetros patriarcales. De este modo, les agentes construyen identidades masculinas y femeninas alternativas que dialogan y tensionan con la heteronormatividad.