bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Cementless Total Hip Arthroplasty with Anatomical AURA II Stem
Authors: Drobniewski Marek , Krasińska Magdalena , Synder Marek , Borowski Andrzej 
Published: August 2020

Background. The aim of the paper is to describe the outcomes of hip arthroplasty with the anatomical AURA II stem (BIOMET).
Material and methods. The study enrolled 189 patients (105 women and 84 men) who underwent a total of 213 hip arthroplasty procedures with the anatomical AURA II stem. Mean age of the patients at surgery was 61.7 years (range: 21 to 76 years) and mean follow-up period was 131.9 months (11 years).
Results. Pre-operative Merle d’Aubigne-Postel scores (modified by Charnley) of the study group were poor in all patients. Mean post-operative improvement in the scores was 6.8 points. Excellent results were obtained in 123 cases, good in 22, fair in 24 and poor in 44 cases. The poor results were always associated with acetabular cup loosening. A total of 13 (6.1%), patients developed heterotopic ossification. According to the Kaplan-Meier estimator, 10 years’ survival probability was 76.19% for the whole endoprosthesis and 100% for the stem alone.
Conclusions. 1. Our follow-up data from a mean of 11 years show that the use of the anatomical AURA II stem results in a considerable reduction in hip pain and produces good and lasting clinical outcomes. 2. With good surgical technique and in the absence of complications, the risk of aseptic loosening is minimal.
Numerical simulation of enhanced oil recovery studies for aqueous gemini surfactant‐polymer‐nanoparticle systems
Authors: Pal Nilanjan , Mandal Ajay 
Published: August 2020

AbstractThe article investigates the efficacy of gemini surfactant/polymer/nanoparticle flooding on chemical EOR. Initially, physicochemical behavior of aqueous chemical fluids were investigated via interfacial tension reduction, wettability alteration, adsorption, viscosity moderation and oil displacement experiments. During compositional analysis, Cartesian model with specified grid properties, injection flow‐rate, well pattern, and rock‐fluid characteristics was developed using CMG‐STARS tool. Contour map analyses showed that oil saturation decreased from ~80% (initial) to 31.96%, 30.68%, and 29.30% after {14‐6‐14 GS + chase water}, {14‐6‐14 GS + PHPA + chase water}, and {14‐6‐14 GS + PHPA + SiO2 chase water} flooding respectively. Tertiary recoveries of 15–19% were achieved, depending on injected fluid composition. Experimental data were history matched via CMOST tool to achieve good matching of simulated results. The CMG flooding simulator provides a holistic approach to investigate oil displacement profiles, assess flooding recovery capabilities with near‐accuracy and predict the feasibility of proposed chemical EOR projects.
Radon and cancer mortality among underground uranium miners in the Příbram region of the Czech Republic
Authors: Kelly‐Reif Kaitlin , Sandler Dale P. , Shore David , Schubauer‐Berigan Mary K. , Troester Melissa A. , Nylander‐French Leena , Richardson David B. 
Published: August 2020

AbstractBackgroundThis study aims to estimate the association between radon and site‐specific cancer mortality among a large contemporary cohort of male uranium miners.MethodsAnnual occupational radon exposure was estimated based on a worker's duration of underground mining in a year and estimates of potential alpha energy of radon progeny in their location of work. Cancer mortality over the period 1977‐1992 was ascertained for a cohort of 16 434 male underground uranium miners employed in the Czech Republic between 1946 and 1992. Poisson regression was used to estimate relationships between cumulative radiation exposure (in working level months [WLM]) and site‐specific cancer mortality.ResultsRadon is positively associated with lung cancer mortality (excess relative rate [ERR] per 100 WLM = 0.2; 95% confidence interval [CI]: 0.10, 0.37). The best fit of the dose‐response relationship between radon and lung cancer mortality was linear and estimates of radon‐lung cancer associations varied by windows of time‐since‐exposure. Positive associations between radon and several types of cancer other than lung cancer were identified, notably chronic lymphocytic leukemia (CLL) (ERR/100 WLM = 0.24; 95% CI: [not determined [ND], 5.10]) and extrathoracic cancer (ERR/100 WLM = 0.12; 95% CI: [ND, 0.69]). We observed no associations between radon and stomach cancer, nor between radon and several hematopoietic cancer subtypes.ConclusionsThis study confirms the established radon‐lung cancer association and suggests that radon may also be associated with other types of cancer mortality. Further investigations of extrathoracic and CLL cancer, with the aim of obtaining more precise estimates, are warranted to understand associations between radon and cancers other than lung.
Massive atrial myxoma requiring emergency cardiopulmonary bypass in a patient with heparin resistance
Authors: Houston E. , Moran P. , Mayhew D. 
Published: August 2020

SummaryHeparin exhibits complex pharmacology with a wide variation in individual response. Despite this, heparin is the most commonly used anticoagulant during cardiopulmonary bypass. Heparin resistance in the context of a patient with severe cardiovascular compromise presents a potentially life‐threatening challenge. A 31‐year‐old woman was listed for emergency excision of a massive left atrial myxoma. On induction of anaesthesia, she developed marked cardiovascular instability secondary to mitral inflow obstruction. An initial heparin dose of 600 units.kg‐1 produced an activated clotting time of 360 s; however, immediate cardiopulmonary bypass was required. Heparin resistance remained problematic throughout the procedure, with an inadequate response to antithrombin three supplementation. Despite a total dose of 120,000 units of heparin, anticoagulation was fully reversed with 500 mg protamine and there was no subsequent re‐heparinisation. Heparin resistance, when coinciding with profound cardiovascular instability, requires a pragmatic response to expedite establishment of cardiopulmonary bypass whilst minimising potential harm. In this case, successful cardiopulmonary bypass was achieved with additional heparin boluses from an alternative batch administered both intravenously and via the bypass circuit. We therefore advocate consideration of this approach as one possible solution to achieving safe entry onto cardiopulmonary bypass in a crisis scenario.
Interaction of Catechol‐O‐methyltransferase Val158Met polymorphism and sex influences association of parietal intrinsic functional connectivity and immediate verbal memory
Authors: Wu Sichu , Upadhyay Neeraj , Lu Jiaming , Jiang Xueyan , Li Shumei , Qing Zhao , Wang Junxia , Liang Xue , Zhang Xin , Zhang Bing 
Published: August 2020

AbstractIntroductionSex differences modulate catechol‐O‐methyltransferase (COMT) genotype effect at a synaptic dopamine level, which influences brain function as well as cognitive performance. In this study, we investigated how COMT Val158Met polymorphism and sex affect intrinsic functional connectivity and memory.MethodsIntrinsic functional networks were extracted using independent component analysis of resting‐state functional magnetic resonance imaging data from 186 healthy young COMT‐genotyped participants. The association of these functional networks and memory function was tested to investigate whether the effect of COMT × sex interaction influences the association of intrinsic functional connectivity and memory performance. Quadratic curve fit estimation was used to examine the relationship between functional connectivity and speculative dopamine level among groups.ResultsCOMT MM/MV carriers, relative to VV carriers, showed increased functional connectivity in left superior parietal lobule and right inferior frontal gyrus. Further, male MM/MV carriers showed significant higher mean functional connectivity in left inferior parietal lobule relative to male VV carriers and female MM/MV carriers, which was associated with worse immediate verbal recall performance. Additionally, the relationship between inferior parietal lobule functional connectivity and speculative dopamine level among groups fits the quadratic curve.ConclusionsThese findings suggest that the interaction of COMT genotype and sex might regulate synaptic dopaminergic concentrations and influence the association of intrinsic functional connectivity and immediate verbal memory in left inferior parietal lobule.
Heterojunction‐Type Photocatalytic System Based on Inorganic Halide Perovskite CsPbBr3†
Authors: Zhu Enbo , Zhao Yizhou , Dai Yi , Wang Qiuhe , Dong Yuanyuan , Chen Qi , Li Yujing 
Published: August 2020

Summary of main observation and conclusionThe heterojunction‐type structure has shown significant merits in tuning the optical properties and carrier physics. Inspired by the excellent absorption capability of halide perovskite materials for visible light, a series of CsPbBr3/TiO2 heterojunction‐type photocatalysts with various all‐inorganic‐perovskite/TiO2 ratios are successfully fabricated by the ligand‐assisted reprecipitation (LARP) method. The heterojunction structure extends the light absorption of TiO2 with good chemical and structural stability. A Pb‐O interaction at the CsPbBr3/TiO2 interface is observed by the XPS and confirmed by the TRPL showing improved interface carrier transport and stability. The heterojunction‐type catalyst shows drastically enhanced photocatalytic activity towards the direct oxidation of toluene with O2 molecule, as an important reaction for organic chemical synthesis. The optimized sample shows an activity of 2356 μmol·g–1·h–1 at 75 °C, 4 times of that of the naked CsPbBr3 nanocrystals, and 3 times of that of the bare TiO2. Based on the investigation with trapping agents, a reaction mechanism is hence proposed suggesting that the photo‐generated hole may be involved in the rate‐limiting step. This work demonstrates the potential of inorganic halide perovskite‐based heterojunction structure for photocatalytic applications.
Profiling Drug‐Protein Interactions by Micro Column Affinity Purification Combined with Label Free Quantification Proteomics†
Authors: Gong Li , Xu Yao , Liu Guizhen , Zheng Mengmeng , Zhang Xuepei , Hang Ying , Kang Jingwu 
Published: August 2020

Summary of main observation and conclusionWe developed a method for comprehensively profiling drug‐protein interactions using micro‐column affinity purification (AP) combined with label‐free quantitative (LFQ) proteomics as well as the statistical and bioinformatics analysis. FK506 was used as the experimental model for proof of concept. The true interacting proteins were distinguished from the background proteins by their fold changes of FLQ intensities combined with p‐values. Totally 116 FK506 interacting proteins including 5 known target proteins were identified. The method was validated by using the LFQ intensity of the endogenous known drug targets together with statistical analysis. We demonstrated that the micro‐column‐based affinity purification in combination with LFQ proteomics provides a highly reproducible and robust approach for profiling drug‐protein interactions.
Influence of relative motion of magnetic field on time‐dependent MHD natural convection flow
Authors: Lawal Khadijah K. , Jibril Haruna M. 
Published: August 2020

AbstractThe effects of relative motion of magnetic field on unsteady magnetohydrodynamic free convection flow with ramped motion and temperature‐dependent heat source/sink have been analyzed. The motion of the inner cylinder is ramped while the motion of the outer cylinder is fixed. The momentum and energy equations are solved using the well‐known Laplace transform. The time‐domain solution is obtained using the Riemann‐sum approximation method. The influence of the governing parameters on fluid velocity, fluid temperature, volume flow rate, and rate of heat transfer are discussed with the help of line graphs. It is found that Hartmann number has a retarding effect on fluid velocity, skin friction at the outer surface of the inner cylinder, and mass flow rate when the magnetic field is fixed with the fluid and when the velocity of the magnetic field is less than the velocity of the moving cylinder. Whereas, the reverse effect is noticed when the magnetic field is fixed with the moving cylinder.
Characterization of clinical pharmacist and hospitalist collaborative relationships
Authors: Olin Jacqueline L. , Anderson Sarah L. , Hellwig Thaddaus R. , Jenkins Antoine T. , Craven Robert , Touchette Daniel R. 
Published: August 2020

AbstractIntroductionHospitalists provide inpatient care including coordinating with other providers and transitioning care to the community. Clinical pharmacists interact with hospitalists, usually on multidisciplinary teams. A statement by the American Society of Health‐System Pharmacists and the Society of Hospital Medicine promotes collaboration and encourages interdisciplinary optimization of patient care. However, literature detailing this collaboration is sparse. It is unclear how to utilize these joint working relationships most effectively.ObjectivesThe purpose of this study was to describe the environment of pharmacist and hospitalist collaborative relationships and activities of pharmacists practicing with hospitalists for foundational information.MethodsThis was a cross‐sectional study. An Institutional Review Board‐approved survey was distributed to pharmacists and hospitalists via email. Questions considered the team and the environment, clinical pharmacist activities related to the pharmacists' patient care process, and perceived barriers to effective teamwork. Results were analyzed with descriptive statistics.ResultsSeventy pharmacists and 25 hospitalists participated in the survey. Most were from the Midwest or Southeast United States and practicing up to 10 years in a large health care system. Pharmacists spent the most time on development of a therapeutic plan (1‐5 ranking scale [1 = most, 5 = least time spent]; median 2; range 1‐5.) There were variations in responses related to the institutional staffing model allowing for collaboration with hospitalists, whether technology enhanced collaboration and additional job responsibilities hindered collaboration, and whether absence of pharmacy participation on rounds was noticed. Most hospitalists (68%) initiated frequent communication with a pharmacist. Hospitalists (32%) would collaborate with a pharmacist more frequently if a specific individual was designated for the position.ConclusionsClinical pharmacists and hospitalists collaborate in team‐based care environments within larger health care systems. This hypothesis‐generating survey attempts to assess the current environment. Further research can work toward establishing practice standards and improving collaborations.
Analytical performance evaluation of the Norudia HbA1c assay
Authors: Lee Joon Hee , Kim Sungmin , Jun Sun‐Hee , Seo Jong Do , Nam Youngwon , Song Sang Hoon , Lee Kyunghoon , Song Junghan 
Published: August 2020

AbstractBackgroundHemoglobin A1c (HbA1c) is arguably the most important biomarker used in the diagnosis and treatment monitoring of diabetes mellitus. We evaluated the analytical performance of the Norudia HbA1c assay (Sekisui Medical Co., LTD), which uses an enzymatic method incorporated into a fully automated, high‐throughput system.MethodsThe precision, linearity, and carryover of the Norudia HbA1c assay were evaluated. Using 60 patient samples, comparative analysis of HbA1c measurements with two commonly used HbA1c assays, the D100 (Bio‐Rad Laboratories, Inc) and HLC‐723 G11 (Tosoh), was undergone. Thirteen commutable samples with known HbA1c concentrations measured using an IFCC reference measurement procedure were used to compare accuracy between methods. Interference of HbA1c measurement by Hb variants was evaluated using 16 known Hb variant samples.ResultsRepeatability (% CV) for low and high concentrations ranged from 1.12%‐1.50% and 0.66%‐0.75%, respectively, and within‐laboratory precision for low and high concentrations ranged from 1.73%‐2.89% and 0.98%‐1.64%, respectively. For linearity, the coefficient of determination was 0.9987. No significant carryover was observed. When compared to the D100 and HLC‐723 G11 assays, the Norudia HbA1c assay showed the best accuracy with the lowest mean bias (−1.72%). Furthermore, the Norudia was least affected by Hb variants and gave the most reliable HbA1c measurements.ConclusionThe Norudia HbA1c showed excellent analytical performance with good precision and linearity, and minimal carryover. When compared to other routine HbA1c methods, the Norudia HbA1c assay showed the highest accuracy and was least affected by Hb variants.
Introducing legislative advocacy into the dental school curriculum: A mixed‐methods evaluation
Authors: Meyer Beau D. , Fearnow Bethany , Wolcott Michael D. 
Published: August 2020

AbstractThe aim of this project was to evaluate a legislative advocacy exercise in pediatric dentistry at 1 North American dental school. A mixed‐methods approach was employed using focus groups and questionnaires. All third‐year dental students (n = 84) participated in an exercise as part of the pediatric dentistry course. Participation in the program evaluation was voluntary. Questionnaires were administered to assess students’ advocacy beliefs, behaviors, self‐efficacy, and knowledge 1 week before and 1 week after the exercise. Six months later, a focus group with questionnaire non‐respondents (n = 9) was conducted to explore participants’ attitudes and beliefs about oral health advocacy within the dental school curriculum. The focus group followed a semi‐structured guide, and transcripts were analyzed using thematic content analysis. Questionnaires were returned from 27 students before (33% response rate) and 23 students (28% response rate) following the advocacy exercise. Students’ advocacy beliefs, behaviors, and knowledge showed no change, whereas self‐efficacy improved following the advocacy exercise. Students enjoyed the advocacy exercise and viewed it as a positive addition to the curriculum; however, they requested more exposure to advocacy across the curriculum. Students described the power of their collective voice rather than a single person as a major driver of policy change. These findings suggest that curricular changes should incorporate experiential advocacy activities more frequently to help students learn about and gain advocacy skills.
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Position paper on diagnosis, prognosis, and treatment by theMNGIEInternational Network
Authors: Hirano Michio , Carelli Valerio , De Giorgio Roberto , Pironi Loris , Accarino Anna , Cenacchi Giovanna , D'Alessandro Roberto , Filosto Massimiliano , Martí Ramon , Nonino Francesco , Pinna Antonio Daniele , Baldin Elisa , Bax Bridget Elizabeth , Bolletta Alessio , Bolletta Riccardo , Boschetti Elisa , Cescon Matteo , D'Angelo Roberto , Dotti Maria Teresa , Giordano Carla , Gramegna Laura Ludovica , Levene Michelle , Lodi Raffaele , Mandel Hanna , Morelli Maria Cristina , Musumeci Olimpia , Pugliese Alessia , Scarpelli Mauro , Siniscalchi Antonio , Spinazzola Antonella , Tal Galit , Torres‐Torronteras Javier , Vignatelli Luca , Zaidman Irina , Zoller Heinz , Rinaldi Rita , Zeviani Massimo 
Published: August 2020

AbstractMitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disease caused byTYMPmutations and thymidine phosphorylase (TP) deficiency. Thymidine and deoxyuridine accumulate impairing the mitochondrial DNA maintenance and integrity. Clinically, patients show severe and progressive gastrointestinal and neurological manifestations. The onset typically occurs in the second decade of life and mean age at death is 37 years. Signs and symptoms of MNGIE are heterogeneous and confirmatory diagnostic tests are not routinely performed by most laboratories, accounting for common misdiagnosis. Factors predictive of progression and appropriate tests for monitoring are still undefined. Several treatment options showed promising results in restoring the biochemical imbalance of MNGIE. The lack of controlled studies with appropriate follow‐up accounts for the limited evidence informing diagnostic and therapeutic choices. The International Consensus Conference (ICC) on MNGIE, held in Bologna, Italy, on 30 March to 31 March 2019, aimed at an evidence‐based consensus on diagnosis, prognosis, and treatment of MNGIE among experts, patients, caregivers and other stakeholders involved in caring the condition. The conference was conducted according to the National Institute of Health Consensus Conference methodology. A consensus development panel formulated a set of statements and proposed a research agenda. Specifically, the ICC produced recommendations on: (a) diagnostic pathway; (b) prognosis and the main predictors of disease progression; (c) efficacy and safety of treatments; and (f) research priorities on diagnosis, prognosis, and treatment. The Bologna ICC on diagnosis, management and treatment of MNGIE provided evidence‐based guidance for clinicians incorporating patients' values and preferences.
Reflections of global warming in trends of temperature characteristics in the Czech Republic, 1961–2019
Authors: Zahradníček Pavel , Brázdil Rudolf , Štěpánek Petr , Trnka Miroslav 
Published: August 2020

AbstractThis paper presents a comprehensive trend analysis of spatiotemporal temperature change patterns over the territory of what is now the Czech Republic (CR) during the 1961–2019 period. Employing daily mean temperatures (TAVG), maximum (TMAX) and minimum (TMIN) temperatures and diurnal temperature range (DTR), supplied by 133 stations of the Czech Hydrometeorological Institute, daily, monthly, seasonal and annual series were calculated for four altitudinal groups and the entire CR, for which linear trends were calculated and further analysed. For the purposes of relative trend comparison, the linear trends were also calculated from standardized series (mean 0, SD 1, in 1961–1990). All seasonal and annual TAVG, TMAX and TMIN series exhibit statistically significant increasing trends, with the exceptions of only a few cases for winter (DJF) and autumn (SON). DTR trends increase significantly in spring (MAM) and summer (JJA), but decrease in DJF and SON. The highest increases in trends occur in JJA and from stations at lower altitudes for groups I (up to 300 m asl) and II (301–600 m asl). Trends in JJA and SON TMIN are relatively higher than in TMAX, while the opposite holds true of DJF and MAM. Comparing the three decades after 1990 with the 1961–1990 normal, each decade was generally warmer than the previous period, with particularly enhanced warming in 2011–2019. This is also reflected in prominent increases in cumulative temperature sums throughout the year. The results obtained are discussed in the context of other European papers and with respect to explaining existing differences.