bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONCRETO PERMEÁVEL COM INCORPORAÇÃO DE RESÍDUOS: UMA REVISÃO
Authors: Moura João Marcos Bosi Mendonça de , Gohr Pinheiro Ivone , Rohden Abrahão Bernardo 
Published: December 2020

O aproveitamento de resíduos no concreto permeável pode reduzir a poluição ambiental assim como contribuir para a diminuição do consumo de matéria prima virgem e da disposição final de resíduos. Neste estudo de revisão analisou-se o resultado de pesquisas sobre concreto permeável com incorporação de resíduos como agregados ou finos. Os artigos selecionados foram buscados em periódicos científicos da base de dados do Science Direct e Scielo entre o ano de 2013 e 2020. A busca resultou em 69 estudos que avaliaram a incorporação de resíduos no concreto permeável. Observou-se predomínio do uso de resíduos da construção civil compostos por concreto, argamassas, blocos e revestimentos cerâmicos. A influência da incorporação de resíduo nas propriedades físicas, mecânicas e hidráulicas do concreto permeável foi analisada, revelando que os melhores resultados são obtidos quando os resíduos são incorporados no concreto permeável como finos.
In vivo Antidiabetic Activities of Aqueous Extract of Anchomanes difformis (Blume) Eng, Rhizophora racemosa G. Mey and Ravenala madagascariensis Sonn
Authors: Camara A. K. , Baldé E. S. , Haidara M. , Camara A. , Guilavogui K. , Sanogo R. , Baldé A. M. 
Published: December 2020

Aims: Anchomanes difformis (Blume) Eng (Araceae), Rhizophora racemosa G. Mey (Rhizophoraceae) and Ravenala madagascariensis Sonn (Strelitziaceae) are used in traditional medicine in Guinea for diabetes management. The aim of this work was to test the antidiabetic activity of these plants and to determine their toxicity.
Material and Methods: Extemporaneous extracts based on these plants were tested for their acute toxicity, their effects in normoglycemic rats and rendered hyper glycemic by the oral route in comparison with the glibenclamide an antidiabetic agent. Swiss albino mice and Male Wistar rats were used respectively for acute oral toxicity and antidiabetic activity.
Results: This study showed that the administration of the 2000 mg / kg dose of dry extracts in mice showed no acute toxicity and adverse effect. At a dose of 400 mg/kg these three plants showed significant hypoglycaemia effect. The average blood glucose levels ranged from 111.2 ± 6.2 to 84.6 ± 6.7 mg/dL (p<0.001) for A. difformis, 110.6 ± 6 to 93.2 mg/dL (p<0.05) for R. racemosa and 99.6 ± 14.4 to 82.3 mg/dL (p<0.05) for R. madagascariensis.
Conclusion: The results obtained on the antidiabetic properties of these three plants corroborates their traditional uses in the management of type 2 diabetes in the Republic of Guinea.
Pharmacologic inhibition of Akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines
Authors: Fabi François , Adam Pascal , Parent Sophie , Tardif Laurence , Cadrin Monique , Asselin Eric 
Published: December 2020

The PI3K/Akt signaling pathway, the most frequently altered signaling system in human cancer, is a crucial inducer of dysregulated proliferation and neoplastic processes; however, few therapeutic strategies using PI3K/Akt inhibitors singly have been shown to be effective. The purpose of this paper was to underline the potential benefit of pharmacological modulation of the PI3K/Akt pathway when combined with specific chemotherapeutic regimens. We have studied the ability of NVP‐BEZ235 (PI3K/mTOR inhibitor) and AZD5363 (Akt inhibitor) in the sensitization of cancer cells to cisplatin and doxorubicin. Our results show that NVP‐BEZ235 sensitizes cells preferentially to cisplatin while AZD5363 sensitizes cells to doxorubicin. At equal concentrations (5 μm), both inhibitors reduce ribosomal protein S6 phosphorylation, but AZD5363 is more effective in reducing GSK3β phosphorylation as well as S6 phosphorylation. Additionally, AZD5363 is capable of inducing FOXO1 and p53 nuclear localization and reduces BAD phosphorylation, which is generally increased by cisplatin and doxorubicin. Finally, the combination of AZD5363 and doxorubicin induces apoptosis in cells and robustly reduces cell ability to clonally replicate, which underlines a potential cooperative effect of the studied compounds.
Auto‐Trending daily quality assurance program for a pencil beam scanning proton system aligned with TG 224
Authors: Shi Chengyu , Chen Qing , Yu Francis , Zhang Jingqiao , Kang Minglei , Tang Shikui , Chang Chang , Lin Haibo 
Published: December 2020

AbstractThe Daily Quality Assurance (DQA) for a proton modality is not standardized. The modern pencil beam scanning proton system is becoming a trend and an increasing number of proton centers with PBS are either under construction or in planning. The American Association of Physicists in Medicine has a Task Group 224 report published in 2019 for proton modality routine QA. Therefore, there is a clinical need to explore a DQA procedure to meet the TG 224 guideline. The MatriXX PT and a customized phantom were used for the dosimetry constancy checking. An OBI box was used for imaging QA. The MyQA(TM) software was used for logging the dosimetry results. An in‐house developed application was applied to log and auto analyze the DQA results. Another in‐house developed program "DailyQATrend" was used to create DQA databases for further analysis. All the functional and easy determined tasks passed. For dosimetry constancy checking, the outputs for four gantry rooms were within ±3% with room to room baseline differences within ±1%. The energy checking was within ±1%. The spot location checking from the baseline was within 0.63 mm and the spot size checking from the baseline was within −1.41 ± 1.27 mm (left–right) and −0.24 ± 1.27 mm (in–out) by averaging all the energies. We have found that there was also a trend for the beam energies of two treatment rooms slowly going down (0.76% per month and 0.48 per month) after analyzing the whole data trend with linear regression. A DQA program for a PBS proton system has been developed and fully implemented into the clinic. The DQA program meets the TG 224 guideline and has web‐based logging and auto treading functions. The clinical data show the DQA program is efficient and has the potential to identify the PBS proton system potential issue.
Potential benefits of adaptive intensity‐modulated proton therapy in nasopharyngeal carcinomas
Authors: Minatogawa Hideki , Yasuda Koichi , Dekura Yasuhiro , Takao Seishin , Matsuura Taeko , Yoshimura Takaaki , Suzuki Ryusuke , Yokota Isao , Fujima Noriyuki , Onimaru Rikiya , Shimizu Shinichi , Aoyama Hidefumi , Shirato Hiroki 
Published: December 2020

AbstractPurposeTo investigate potential advantages of adaptive intensity‐modulated proton beam therapy (A‐IMPT) by comparing it to adaptive intensity‐modulated X‐ray therapy (A‐IMXT) for nasopharyngeal carcinomas (NPC).MethodsTen patients with NPC treated with A‐IMXT (step and shoot approach) and concomitant chemotherapy between 2014 and 2016 were selected. In the actual treatment, 46 Gy in 23 fractions (46Gy/23Fx.) was prescribed using the initial plan and 24Gy/12Fx was prescribed using an adapted plan thereafter. New treatment planning of A‐IMPT was made for the same patients using equivalent dose fractionation schedule and dose constraints. The dose volume statistics based on deformable images and dose accumulation was used in the comparison of A‐IMXT with A‐IMPT.ResultsThe means of the Dmean of the right parotid gland (P < 0.001), right TM joint (P < 0.001), left TM joint (P < 0.001), oral cavity (P < 0.001), supraglottic larynx (P = 0.001), glottic larynx (P < 0.001), , middle PCM (P = 0.0371), interior PCM (P < 0.001), cricopharyngeal muscle (P = 0.03643), and thyroid gland (P = 0.00216), in A‐IMPT are lower than those of A‐IMXT, with statistical significance. The means of, D0.03cc, and Dmean of each sub portion of auditory apparatus and D30% for Eustachian tube and D0.5cc for mastoid volume in A‐IMPT are significantly lower than those of A‐IMXT. The mean doses to the oral cavity, supraglottic larynx, and glottic larynx were all reduced by more than 20 Gy (RBE = 1.1).ConclusionsAn adaptive approach is suggested to enhance the potential benefit of IMPT compared to IMXT to reduce adverse effects for patients with NPC.
Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo
Authors: Lin Kai , Ma Zhao , Li Jin , Tang Menghuan , Lindstrom Aaron , Ramachandran Mythili , Zhu Shaoming , Lin Tzu‐yin , Zhang Lanwei , Li Yuanpei 
Published: December 2020

AbstractPhotodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular localization and poor intratumoral retention of small‐molecule photosensitizes. Here a fiber‐forming nanophotosensitizer (PQC NF) that is composed of mitochondria targeting small molecules of amphiphilicity is reported. Harnessing the specific mitochondria targeting, the light‐activated PQC NFs produce approximately 110‐fold higher amount of reactive oxygen species in cells than free photosensitizers and can dramatically induce mitochondrial disruption to trigger intense apoptosis, showing 20–50 times better in vitro anticancer potency than traditional photosensitizers. As fiber‐shaped nanomaterials, PQC NFs also demonstrated a long‐term retention in tumor sites, solving the challenge of rapid clearance of small‐molecule photosensitizers from tumors. With these advantages, PQC NFs achieve a 100% complete cure rate in both subcutaneous and orthotopic oral cancer models with the administration of only a single dose. This type of single small molecule‐assembled mitochondria targeting nanofibers offers an advantageous strategy to improve the in vivo therapeutic effects of conventional PDT.
Tough and Flexible, Super Ion‐Conductive Electrolyte Membranes for Lithium‐Based Secondary Battery Applications
Authors: Mong Anh Le , Shi Qing Xuan , Jeon Hyungjoon , Ye Yun Sheng , Xie Xiao Lin , Kim Dukjoon 
Published: December 2020

AbstractRecently, stringent requirements brought on by environmental regulations and safety issues are driving the development of solid electrolytes to replace conventional liquid electrolyte systems for lithium‐based secondary batteries (LiBs). However, the low Li‐ion conductivity and/or poor mechanical properties of electrolytes remain the main obstacles hindering their commercialization. Hierarchitectural and composite polymer separators (CPSs) based on electrolyte membranes have been reported as promising tools for both high ionic conductivity and mechanical stability. In light of such work, the new types of flexible electrolytes based on phase‐separated and mixed‐phase morphologies achieved via self‐assembly and the use of functional molecular composites are reviewed along with the fundamental mechanisms associated with such systems. In particular, the structure and morphology, ionic conductivity, thermal/mechanical stability, and fabrication of polymer electrolytes are introduced. Additionally, recent advancements in CPSs including methods of ensuring low interfacial resistance, the respective contributions of these critical factors to the significant functional properties of CPSs, and directions for development and essential applications in the field of CPSs for LiBs are presented. Based on previous works, the perspectives put forth will aid in the design of advanced electrolytes for practical Li secondary batteries in the near future.
Ligand‐Programmed Consecutive Symmetry Break(s) in Nanoparticle Based Materials Showing Emergent Phenomena: Transitioning from Sixfold to Threefold Symmetry in Anisotropic ZnO Colloids
Authors: Theiss Sebastian , Voggel Michael , Kuper Henning , Hoermann Martin , Krings Ulrich , Baum Peter , Becker Joerg August , Wittmann Valentin , Polarz Sebastian 
Published: December 2020

AbstractThe central promise of nanoparticle‐based materials is that cooperative properties may emerge, when individual quantum dots are positioned on a periodic lattice. Yet, there are only a few papers in the literature reporting such effects. Nevertheless, it is clear that the symmetry of the superlattice is decisive for the desired emergent phenomena. An interesting question is, how the symmetry of the initial monodisperse nanoparticles affects the structure of the colloidal crystal during self‐assembly processes. For instance, particles with a hexagonal cross‐section demonstrate self‐organization, which is very similar to spherical colloids. Likewise, one would also expect that trigonal nanoparticles behave similarly. Unfortunately, it is very hard to obtain monodisperse semiconductor colloids with a trigonal shape, because this requires a symmetry break during morphogenesis of the nanocrystal. While such a symmetry break is known in the literature for structures attached to a solid substrate, herein, colloidal synthesis of trigonal ZnO nanorods is successfully demonstrated, and the mechanism is elucidated via experimental and theoretical methods. 2D‐superlattices formed by such particles with trigonal cross‐section are compared to hexagonal analogues. It is found that there are distinct differences, which result in important differences in properties such as the formation of voids and also in optical properties.
Smart Laser‐Writable Micropatterns with Multiscale Photo/Moisture Reconstructible Structure
Authors: Zeng Songshan , Liu Yin , Li Shuliang , Shen Kuangyu , Hou Zaili , Chooi Aimee P. , Smith Andrew T. , Chen Zi , Sun Luyi 
Published: December 2020

AbstractThe design of a dynamic, versatile, convertible, and responsive micropatterned system is realized by a photo/moisture reconstructible multiscale film‐substrate bilayer structure. Specifically, a hydrophilic polyvinyl alcohol (PVA)/laponite (LP) thin film is covalently bonded to a photothermally active polydimethylsiloxane (PDMS)/carbon black (CB) soft substrate. A laser engraver can inscribe programmable aligned micro‐wrinkles by manipulating laser power and spatiotemporal control. These wrinkles can be modulated into three distinct systems 1) moisture erasable and laser re‐writable wrinkles; 2) moisture driven reversible wrinkles; 3) moisture resistant wrinkles, which are achieved by controlling a) the moisture resistance of PVA; b) the dimensional stability of PVA/LP film regulated by the LP nanostructure, which can be adjusted by the laser power and the LP ratio. This programmable system can be applied in information encryption/recording and as a moisture responsive electrical switch, offering new routes for the modulations and applications of next generation smart materials.
Extremely Fast Optical and Nonvolatile Control of Mixed‐Phase Multiferroic BiFeO3 via Instantaneous Strain Perturbation
Authors: Liou Yi‐De , Ho Sheng‐Zhu , Tzeng Wen‐Yen , Liu Yu‐Chen , Wu Ping‐Chun , Zheng Junding , Huang Rong , Duan Chun‐Gang , Kuo Chang‐Yang , Luo Chih‐Wei , Chen Yi‐Chun , Yang Jan‐Chi 
Published: December 2020

AbstractMultiferroics—materials that exhibit coupled ferroic orders—are considered to be one of the most promising candidate material systems for next‐generation spintronics, memory, low‐power nanoelectronics and so on. To advance potential applications, approaches that lead to persistent and extremely fast functional property changes are in demand. Herein, it is revealed that the phase transition and the correlated ferroic orders in multiferroic BiFeO3 (BFO) can be modulated via illumination of single short/ultrashort light pulses. Heat transport simulations and ultrafast optical pump‐probe spectroscopy reveal that the transient strain induced by light pulses plays a key role in determining the persistent final states. Having identified the diffusionless phase transformation features via scanning transmission electron microscopy, sequential laser pulse illumination is further demonstrated to perform large‐area phase and domain manipulation in a deterministic way. The work contributes to all‐optical and rapid nonvolatile control of multiferroicity, offering different routes while designing novel optoelectronics.
High Efficiency Polarization‐Encoded Holograms with Ultrathin Bilayer Spin‐Decoupled Information Metasurfaces
Authors: Wang Zheng Xing , Wu Jun Wei , Wu Liang Wei , Gou Yue , Ma Hui Feng , Cheng Qiang , Cui Tie Jun 
Published: December 2020

AbstractInformation metasurfaces, including digital coding and programmable metasurfaces, have reformed the design theory of metasurfaces from effective medium to coding pattern, and bridged the physical and digital world. Metasurface hologram has shown great potential in imaging and manipulating electromagnetic waves. In this work, bilayer information metasurfaces are proposed to achieve polarization‐encoded holograms in microwave regime. The designed metasurfaces consist of 3‐bit spin‐decoupled meta‐atoms, which possess ultrathin profiles (0.14λ0) and high cross‐polarization transmittance (over 0.8). The incident wave, which is right‐handed circularly polarized or left‐handed circularly polarized, is encoded with code “0” or “1”. The spin‐decoupled design is combined with diffuse scattering and holographic technology. Based on this, a novel algorithm is proposed to generate coding sequences according to the code of incident wave, to achieve different functionalities for corresponding circularly polarized channels. In this way, polarization‐encoded holograms, including diffuse scattering holograms (code “00”), single channel holograms (code “01” or “10”), and spin‐selective holograms (code “11”), are achieved. Simulated and measured results show that the maximum imaging efficiency can reach up to 65.1%, verifying the high efficiency of this holographic technology. This work is expected to open a way of realizing more complicated and higher efficiency information metasurface holography.
Reconfigurable Perovskite LEC: Effects of Ionic Additives and Dual Function Devices
Authors: Gets Dmitry , Alahbakhshi Masoud , Mishra Aditya , Haroldson Ross , Papadimitratos Alexios , Ishteev Artur , Saranin Danila , Anoshkin Sergey , Pushkarev Anatoly , Danilovskiy Eduard , Makarov Sergey , Slinker Jason D. , Zakhidov Anvar A. 
Published: December 2020

AbstractHybrid organic–inorganic perovskite light‐emitting devices (LEDs) have recently shown the characteristic dynamical behavior of light‐emitting electrochemical cells (LECs), with intrinsic ionic migration creating an electric double layer and internal p‐i‐n structure and by accumulation of ions at interfaces. Therefore, the development of perovskite light‐emitting and photovoltaic devices based on the concepts of LEC operation attracts much attention and clarifies general physical processes in perovskites. Here, new directions that can further improve perovskite optoelectronic devices and extend their functionalities using additive mobile ions are overviewed: 1) enhancing single‐layer LECs with lithium additives for increased efficiency and longer lifetime; 2) facilitating ionic motion in three‐layer perovskite LECs to create dual‐functional devices, operating as both LEC and solar cells; and 3) creating truly ambipolar LEC devices with carbon nanotubes as stable electrodes that leverage ionic doping. Taken together, the use of these approaches provides a strategy to create efficient, stable, and bright LECs, which use advantages of both LED and LEC operation. It is discussed that how the LEC behavior in perovskite LEDs can be further improved to address the long‐term challenges in perovskite optoelectronics, such as stability, through approaches like ionically reconfigurable host/guest systems.
Thermomorphic Polyethylene‐Supported Organocatalysts for the Valorization of Vegetable Oils and CO2
Authors: Akhdar Ayman , Onida Killian , Vu Nam Duc , Grollier Kevin , Norsic Sébastien , Boisson Christophe , D'Agosto Franck , Duguet Nicolas 
Published: December 2020

AbstractA range of thermomorphic polyethylene‐supported organocatalysts is prepared from N‐alkyl imidazoles and polyethylene iodide (PEI) with good yields (85–92%) and high funtionality (98–99%). The catalytic activity of these species is studied for the ring opening of epoxidized methyl oleate with CO2 to give the corresponding cyclic carbonate. The reaction is carried out at 100 °C to fully exploit the thermomorphic behavior of the organocatalysts. The optimized conditions (neat, 100 °C, and 20 bar of CO2) are applied to a range of epoxidized fatty acids, including an epoxidized rapeseed oil, to give the corresponding carbonates with good yields (75–96%). The catalyst recycling is also studied, and no significant loss of activity is observed after ten runs. The fatty carbonates are important intermediates for the preparation of non‐isocyanate polyurethanes (NIPUs).
Electrothermal Color Tuning of Cholesteric Liquid Crystals Using Interdigitated Electrode Patterns
Authors: Froyen Arne A. F. , Wübbenhorst Michael , Liu Danqing , Schenning Albert P. H. J. 
Published: December 2020

AbstractA transparent color‐tunable device is presented based on an electrothermal response by using interdigitated electrode patterns. The response is generated by applying an in‐plane AC electric field that heats up a thermosensitive cholesteric liquid crystal mixture. The induced temperature elevations cause band gap shifting (Δλ > 350 nm) up until a colorless state is reached, corresponding to the isotropic phase. Color shifting can be tuned manually by varying the electric field or autonomously by the surrounding temperature. Broadband dielectric spectroscopy reveals that the electrothermal response originates from resistive heating of the transparent electrode pattern in conjunction with the cell capacitance and is therefore largely dependent on the electrode configuration. Hence, the electrothermal response can be easily modified by changing the electrode pattern, frequency and/or voltage, dependent on the user's requirements. Therefore, the ability of this technique to manipulate the autonomous thermal response by an electric field, using only one conductive substrate, shows promise in the field of optoelectronics, sensors, and smart windows.
Sustained Release‐Driven Formation of Ultrastable SEI between Li6PS5Cl and Lithium Anode for Sulfide‐Based Solid‐State Batteries
Authors: Chen Ya , Li Wenwen , Sun Changzhi , Jin Jun , Wang Qing , Chen Xiaodong , Zha Wenping , Wen Zhaoyin 
Published: December 2020

AbstractThe sulfide‐type solid electrolyte (SSE) is considered a promising candidate for solid‐state lithium metal batteries (SSLMBs) owing to its advantages of superior ionic conductivity. Nevertheless, the incompatibility of the sulfide and lithium metal can result in undesirable interface resistance and rapid Li dendrite growth, which seriously hinders its commercial applications. Herein, inspired by the moderation and long duration of sustained release drug carriers when combined with active pharmaceutical ingredients in the biomedical field, poly (propylene carbonate) (PPC) and lithium bis (trifluoromethanesulfonyl) imide (LiTFSI) gradually interact with a Li anode with constantly decreased Li/SSE interfacial resistance. In addition to intimate contact, the ultrastable LiF‐enriched solid electrolyte interphase (SEI) is in situ formed via a sustained release effect, which suppresses the Li dendrite effectively. As a result, the symmetric cells demonstrate stable cycling performance for 1200 h at a current density of 0.1 mA cm−2 and 300 h at 0.5 mA cm−2. Moreover, LiFePO4/ Li6PS5Cl /Li SSLMB delivers a high discharge capacity of over 132.8 mAh g−1 for 900 cycles at 1C with steady Coulombic efficiency. Therefore, this sustained release mechanism and its initially successful application in interfacial modification increase the potential for commercial applications of SSLMBs.