bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental mental health conditions and use of healthcare services in children the first year of life – a register-based, nationwide study
Authors: Heuckendorff Signe , Johansen Martin Nygård , Johnsen Søren Paaske , Overgaard Charlotte , Fonager Kirsten 
Published: May 2020

Abstract
Background Parental mental health conditions have been associated with increased morbidity and use of healthcare services in the offspring. However, existing studies have not examined different severities of mental health conditions. Furthermore, the impact of paternal mental health has been overlooked.We therefore examined the association between two severities of parental mental health conditions and the use of healthcare services for children the first year of life, exploring the impact of both maternal and paternal mental health conditions.Methods This register-based cohort study included all live-born children in Denmark 2000-2016. Information on socioeconomics, diagnoses, drug prescriptions and healthcare contacts was extracted from nationwide public registries. Parents were grouped according to severity, and thus the place of treatment, of the mental health condition. Poisson regression analyses were performed to estimate the incidence rate ratio (IRR) of contacts to general practice (GP), out-of-hour medical service, emergency room (ER) and out- and inpatient hospital contacts the first 12 months of life.Results The analyses included 964395 children. Twenty percent of the mothers and twelve percent of the father were identified with mental health condition. Paternal mental health conditions were independent associated with an increased risk of all kinds of infant healthcare contacts (GP IRR 1.05 (CI95% 1.04-1.05) and out-of-hour IRR 1.20 (CI95% 1.18-1.21)); however, the risks were higher for maternal mental health condition (GP IRR 1.17 (CI95% 1.17-1.18) and out-of-hour IRR 1.38 (CI95% 1.37-1.37)). The risks were even higher if both parents were classified with a mental health condition (GP IRR 1.24 (CI95% 1.23-1.25) and out-of-hour contacts IRR 1.48 (CI95% 1.45-1.51)), including minor (GP IRR 1.22 (CI95% 1.22-1.23) and out-of-hour IRR 1.37 (CI95% 1.35-1.39)). The overall pattern was the same for all types of healthcare contacts.Conclusions Both maternal and paternal mental health conditions, including minor mental health conditions, were associated with increased utilization of healthcare services. Focus on both parents as well as the presence of even minor mental health conditions may be warranted in planning of services. What is already known on this subject?Maternal depression or depressive symptoms and/or increase child use of healthcare services. The role of different levels of mental health conditions in the mother as well as mental health conditions of the father are unknown.What this study addsNot only maternal but also paternal mental health conditions, including minor conditions only handled in primary healthcare, increased child use of healthcare services the first year of life. Healthcare utilization was greatest if both parents had a mental health condition.
The design of an “H” joystick for closed reduction and its application in segmental and comminuted femoral shaft fractures: an innovative technique
Authors: Jia Zhaofeng , Wang Shijin , Xiao Tinghui , Jiang Wei , Zhou Tianjian , Liu Qisong , Li Guangheng , Hu Xinjia 
Published: May 2020

Abstract
Background
Closed reduction and locked intramedullary nailing has become a common surgical method in the treatment of femoral shaft fractures. Overlap and rotation displacements can usually be corrected through the use of an orthopaedic traction table. However, lateral displacement and angulation persist.
Methods
In this paper, we describe a joystick that can be used in the closed reduction of a fracture. It can correct lateral displacement and angulation and has the advantage of multi-direction reduction. The device described in this paper includes two parallel horizontal joysticks, one vertical main joystick and four assistant rods. Moreover, there are many specific spacing holes in the two parallel horizontal joysticks and a groove structure in the vertical main joystick. When the main “H” joystick is pressed, it can adjust lateral displacements and angulation because of the lever principle. The distance between parallel horizontal joysticks and assistant rods can be adjusted to the fracture position and body mass index of different patients.
Results
The study participants consisted of 11 males and 5 females with a mean age of 31.0 years. All participants had good closed reduction and achieved bony union without any complications such as infection, nerve injury, nonunion, malunion and limb length discrepancy. By using an “H” joystick, closed femoral shaft fracture reduction and locked intramedullary nailing becomes simpler and faster.
Conclusion
Based on the use of this instrument, we can easily and conveniently obtain the correct reduction situation, which leads to better surgical results. This device can be applied in the reduction of clinical femoral fractures and gradually extended to the reduction of other fractures.
Evaluation of Methods to Optimise Shotgun Metagenomic Sequencing-Based Analysis of the Microbiome of Milk
Authors: Yap Min , Feehily Conor , Walsh Calum J. , Fenelon Mark , Murphy Eileen F. , McAuliffe Fionnuala M. , Sinderen Douwe van , O’Toole Paul W , O’Sullivan Orla , Cotter Paul 
Published: May 2020

Abstract
Background: Shotgun metagenomic sequencing is a valuable tool for the taxonomic and functional profiling of microbial communities. However, this approach is challenging in samples, such as milk, where a low microbial abundance, combined with high levels of host DNA, result in inefficient and uneconomical sequencing.Results: Here we evaluate approaches to deplete host DNA or enrich microbial DNA prior to sequencing using three commercially available kits. We compared the percentage of microbial reads obtained from each kit after shotgun metagenomic sequencing. Using bovine and human milk samples, we determined that host depletion with the MolYsis complete5 kit significantly improved microbial sequencing depth compared to other approaches. Importantly, no biases were introduced. Additionally, the increased microbial sequencing depth allowed for further characterization of the microbiome through the generation of metagenome-assembled genomes (MAGs). Conclusions: This evaluation shows that microbiome analysis can be performed on both bovine and human milk samples at a much greater resolution without the need for more expensive deep-sequencing approaches.
Analysis on influencing factors of viral load in patients with high-risk human papillomavirus
Authors: lu xuerong , Wang Tiantian , Zhang Youzhong , Liu Yuzhen 
Published: May 2020

Abstract
Background
High-risk human papillomavirus (HR-HPV) load is thought to be influenced by many factors, and relationship between viral load and degree of cervical lesion is controversial. This study was to explore possible influencing factors of HR-HPV viral load in uterine cervix.
Methods
605 women who needed colposcopic evaluation for abnormal cervical screening in Affiliated Hospital of Weifang Medical University, China, between November 2017 and September 2018 were enrolled. Cervical specimens were collected from endo- and ectocervix separately using two different cervical brushes. Hybrid Capture II test was used to measure HR-HPV load. Age, histological severity, number of viral types, area and location of cervical lesions were recorded. The correlation between viral load and influencing factors was analysed using univariate and multivariate analysis.
Results
HR-HPV load was positively correlated with age, histological severity, multiple HPV types and area of cervical lesions (P < 0.05). Viral load with combination of endo- and ectocervical sampling was significantly higher than simple endocervical sampling (P < 0.001). Multivariate analysis showed that age, multiple HPV types and area of cervical lesions were independent factors for HR-HPV load with combination of endo- and ectocervical sampling (P < 0.05). However, only age and area of cervical lesions were independent factors for viral load with simple endocervical sampling (P < 0.05). No significant association was found between viral load and lesion severity in multivariate analysis (P > 0.05).
Conclusion
HR-HPV load is influenced by age, histological severity, multiple viral types, area of cervical lesion and sampling methods. Age and area of cervical lesions are independent factors for viral load.
Prevalence of seropositivity of selected Herpesviruses in patients with Multiple Sclerosis in the North of Jordan
Authors: Kofahi Raid , Kofahi Hassan , Sabaheen Suhib , Qawasmeh Majdi Al , Momani Aiman , Yassin Ahmed , Alhayk Kefah , El-Salem Khalid 
Published: May 2020

Abstract
BackgroundMultiple sclerosis (MS) is a neurological disease that is caused by an autoimmune response that results in the demyelination of the neurons in the central nervous system. The exact etiology of MS is not clear; however, several environmental and genetic factors are believed to participate in its initiation and development, including exposure to viruses.AimThe aim of this study is to investigate the association between the seropositivity and antibody titer of selected herpesviruses and MS in Jordanian MS patients.MethodIn this study, 55 MS patients and 40 age- and gender-matching apparently healthy volunteers were recruited from two main hospitals in the north of Jordan. MS patients were grouped into three types of MS based on the clinical presentation of the disease. Blood samples were collected from the participants and the IgG antibodies for human herpes virus 6 (HHV-6), Epstein Barr virus (EBV) nuclear antigen (EBNA), EBV viral capsid antigen (VCA) and varicella zoster virus (VZV) were assayed by ELISA. The prevalence of seropositivity and the antibody level for each of the antibodies were compared between MS patients and controls and between the three types of MS.ResultsThere was no significant difference in the prevalence of seropositivity and in the levels of antibodies for HHV-6, EBNA and VCA between MS patients and controls and between the three types of MS. In contrast, the number of seropositive patients and the level of IgG antibodies for VZV were significantly higher in MS patients compared to the control.ConclusionThis study showed that patients with MS in the north of Jordan were more likely to be seropositive for VZV than the general population. Based on this finding, we recommend further studies to evaluate the seropositivity to VZV to be carried out in other parts of Jordan and the greater middle east to find out if there is correlation between MS and previous infection with VZV.
Hotspots of female genital mutilation/cutting and associated factors among girls in Ethiopia: a spatial and multilevel analysis
Authors: Geremew Tesfahun Taddege , Azage Muluken , Worku Endalkachew 
Published: May 2020

Abstract
Background: Female genital mutilation/cutting (FGM/C) is a harmful traditional practice that violates the human rights of girls and women. It is widely practiced mainly in Africa including Ethiopia. There are a number of studies on the prevalence of FGM/C in Ethiopia. However, little has been devoted to its spatial epidemiology and associated factors. Hence, this study aimed to explore the spatial pattern and factors affecting FGM/C among girls in Ethiopia. Methods : A further analysis of the 2016 Ethiopia Demographic and Health Survey data was conducted, and a total of 6,985 girls nested in 603 enumeration areas were included. Moran's I statistic was employed to test the spatial autocorrelation, and Getis-Ord Gi* as well as Kulldorff’s spatial scan statistics were used to detect spatial clusters of FGM/C. Multilevel logistic regression models were fitted to identify individual and community level factors affecting FGM/C. Results : Spatial clustering of FGM/C was observed (Moran’s I=0.31, p-value < 0.01), and eight significant clusters of FGM/C were detected. The most likely primary cluster was detected in the neighborhood areas of Amhara, Afar, Tigray and Oromia regions (LLR = 279.0, p< 0.01), the secondary cluster in Tigray region (LLR=67.3, p<0.01), and the third cluster in Somali region (LLR=55.5, P<0.01). In About 83% variation in the odds of FGM/C was attributed to both individual and community level factors. At individual level, older maternal age, higher number of living children, maternal circumcision, perceived believes as FGM/C is required by religion, and supporting the continuation of FGM/C practice were factors to increase the odds of FGM/C, whereas, secondary/higher maternal education, better household wealth, and media exposure were factors decreasing the odds of FGM/C. Place of residency, Region and Ethnicity were the community level factors associated with FGM/C. Conclusions: Spatial clustering of FGM/C among girls was observed, and FGM/C hotspots were detected in Afar, Amhara, Tigray, BenishangulGumuz, Oromia, SNNPR and Somali regions including Dire Dawa Town. Both individual and community level factors play a significant role in the practice of FGM/C. Hence, FGM/C hotspots require priority interventions, and it is also better to consider both individual and community level factors.
Magnitude and associated factors of unmet need of modern family planning among reproductive age women in south Gondar zone, North West Ethiopia, 2017
Authors: Chanie Muluken Genetu , Ewuneite Gojjam Eshetie , Dereje Mamo 
Published: May 2020

Abstract
Background: The aim of this study was to identify the prevalence and associated factors of unmet need of modern family planning among reproductive age women in south Gondar zone.Methods: A community based cross-sectional study design was conducted in south Gondar zone among 528 reproductive age women. Data were collected with pre-tested, structured, interviewer administered questionnaires. Data were coded and entered into Epi info version 7 and exported to SPSS version 20. Bivariable and multivariable logistic regression models were applied. A P-value 0.05 was considered to declare a result as significant at 95% CI.Result: -The overall unmet need in this study area was 22.6%, from whom 15.1% respondents were wanted children later and 7.5% were wanted no more children. Women who had been visited by health care providers within 12 months prior to the study, current menstrual status of women, desired number of children and induced abortion were found to be the main factors. Conclusion: -Unmet need for family planning was found to be high in the study area as compared to national and regional prevalence. Women who had been visited by health care providers, Current menstruation status, desired number of children and induced abortion were significantly associated with unmet need of modern family planning. Healthcare providers recurrent visit need to be performed by family planning providers and women empowerment to decide numbers of children are very important areas to decrease unmet need of modern FP.
Clinical course and features of critical patients with COVID-19: a single- center, retrospective study from Wuhan Huoshenshan Hospital
Authors: He Huisi , Jin Zhichao , Ren Yibin , Wang Junxue , Wen Wen , Miao Yushan , Qi Xuewei , Shang Taiyu , Zhang Chenxu , Wang Hongyang , Li Weiqin , Zhang Xijing , Tang Hao 
Published: May 2020

Abstract
Background : The coronavirus pandemic has become a growing public health concern worldwide, and there are insufficient epidemiological data on critical illness. Objective: To investigate the clinical course and features of critical patients with Corona Virus Disease 2019 ( COVID-19 ). Methods: The data on 94 consecutive critical patients from 8 th February through 16 th March 2020, including demographic and clinical information, were obtained from the intensive care unit (ICU) of Wuhan Huoshenshan Hospital. A cross-sectional survey and comparisons of key biomarkers between survivors and nonsurvivors were performed. Results: Over the study period, 42 nonsurvivors and 52 survivors were included. The overall case fatality rate for critical patients with COVID-19 was approximately 45%. The average age was 69.17±9.55 years, and the majority had underlying health problems such as hypertension (56[60%]) and diabetes (18[19%]). The median length of ICU stay was 8 days (IQR 4, 13). Compared with survivors, nonsurvivors were more likely to develop sepsis (42[100%] vs. 34[65%]), acute respiratory distress syndrome (40[95%] vs. 28[54%]) and organ dysfunction. In addition, the dynamic changes in some biomarkers were significantly different between the two groups. The trajectories of temperature revealed that the group with a high temperature on admission that steadily declined had the highest percentage of deaths (93.33%). Conclusions: Patients aged 60 years or older with many concomitant diseases were at highest risk, and the fatality rate started to increase with age. Lymphocyte, platelet, C-reactive protein and hypersensitivity troponin I were revealed to have potential as prognostic factors, whereas some other biomarkers, such as hepatic enzymes, may not offer additional information. Moreover, patients with high temperatures on admission should receive extra care.
Patient and Surgeon Perceptions of the Surgical Risk Preoperative Assessment System (SURPAS): A Mixed Methods Analysis
Authors: Bronsert Michael R. , Lambert-Kerzner Anne , Henderson William G. , Hammermeister Karl E. , Atuanya Chisom , Aasen Davis M , Singh Abhinav B. , Meguid Robert A. 
Published: May 2020

Abstract
Background Risk assessment is essential to informed decision making in surgery. Preoperative use of the Surgical Risk Preoperative Assessment System (SURPAS) providing individualized risk assessment, may enhance informed consent. We assessed patient and provider perceptions of SURPAS as a risk assessment tool. Methods A convergent mixed-methods study assessed SURPAS’s trial implementation, concurrently collecting quantitative and qualitative data, separately analyzing it, and integrating the results. Patients and providers were surveyed and interviewed on their opinion of how SURPAS impacted the preoperative encounter. Relationships between patient risk and patient and provider assessment of SURPAS were examined. Results 197 patients were provided their SURPAS postoperative risk estimates in nine surgeon’s clinics. 98.8% of patients reported they understood their surgical risks very or quite well after exposure to SURPAS; 92.7% reported SURPAS was very helpful or helpful. 83.4% of the time providers reported SURPAS was very or somewhat helpful; 44.7% of the time the providers reported it changed their interaction with the patient and this change was beneficial 94.3% of the time. As patient risk increased, providers reported that SURPAS was increasingly helpful (p<0.0001).Conclusions Patients and providers reported the use of SURPAS helpful and informative during the preoperative risk assessment of patients, thus improving the surgical decision making process. Patients thought that SURPAS was helpful regardless of their risk level, whereas providers thought that SURPAS was more helpful in higher risk patients.
Factors Influencing Chiropractors Who Choose not to Join Professional Associations
Authors: Innes Stanley I , Cope Vicki , Young Kenneth J 
Published: May 2020

Abstract
Background Professional associations are perceived to promote their professions and support their members. They can provide assistance with complaints, negotiate favourable professional indemnity insurance rates, provide access to research libraries and databases, and organise continuing professional development events. Despite these apparent advantages, about 1 in 3 Australian chiropractors choose not to belong to either of the two professional associations. Our study had three objectives: 1) to explore the views of non-member chiropractors about professional associations in general; and 2) seek to understand the motivations of non-member Australian chiropractors about not joining a professional association; and 3) to discover their reasons that might lead them to join a professional association. Methods This was a qualitative descriptive study utilising in-depth semi-structured interviews with open-ended questions for thematic analysis conducted from January to March 2020. It was estimated that between 6 -15 participants in total would be required to achieve saturation of data, that is, the point where no new themes were being articulated. Participants had to be registered chiropractors who had not been members of a professional association (PA) for the last five years. Recruitment was through a Facebook ad and snowball sampling. Interviews were transcribed and imported into NVivo qualitative analysis software, allowing identification of key concepts surrounding non-membership of chiropractic professional associations. Results Five themes were identified from the data. They were: “Not worth the money”, “Tarnished image of the profession”, “Going it alone / what’s in it for me”, “Lack of visibility”, and “Two warring factions”. The most commonly voiced suggestions for improvement included providing continuing professional development/lectures, frequent email updates about events affecting practice/business, improve the image of the profession through the media, and act as a regulator to the profession. Conclusions Non-members are looking for PAs to enhance the respectability of the profession in a manner that ultimately results in increased patient volume and the provision of readily accessible day-to-day resources and information. These results can inform the construction of a survey for the broader chiropractic non-membership community to confirm and expand upon these findings and improve PAs.
Adjuvant Therapy Using Lenvatinib Prevents Recurrence of High-Risk Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma Following Liver Transplantation: A Retrospective Case Control Study
Authors: Han Bing , Ding Han , Zhao Shuai , Zhang Yichi , Wang Jian , Gu Jinyang 
Published: May 2020

Abstract
Background: Although liver transplantation (LT) is one of the most effective treatments for the patients with hepatocellular carcinoma (HCC), the high-risk patients suffer from a high ratio of tumor recurrence after LT. So this study was designed to evaluate the role of adjuvant lenvatinib in preventing recurrence of high-risk LT recipients with HBV-related HCC.Methods: We retrospectively analyzed 23 high-risk patients consisting of lenvatinib group (n = 14) and control group (n = 9) with HBV-related HCC who underwent LT in our center. Disease-free survival (DFS) and HCC recurrence of the two groups were compared. The adverse events (AEs) and drug tolerance of lenvatinib were evaluated.Results: The median DFS in lenvatinib group was 291 (95%CI 204–516) days, significantly longer than 182 (95%CI 56–537) days in control group (P = 0.04). Three patients in lenvatinib group (21.4%) and 5 patients in control group (55.6%) had short-term HCC recurrence (P = 0.11). All patients in lenvatinib group could tolerate oral lenvatinib for at least 3 cycles except 6 cases (42.9%) of dose reduction and 1 case of interruption (14.3%). Thirteen patients (92.9%) taking lenvatinib experienced AEs. The most common AEs were hypertension (64.3%) and proteinuria (42.9%), and the most serious AEs were CTCAE Grade 3 for 4 cases (28.5%). Additionally, no influence of lenvatinib on the dosage and blood concentration of FK506 was observed.Conclusion: Adjuvant lenvatinib had a potential benefit on prolonging the DFS and reducing the recurrence of high-risk HBV-related HCC patients following liver transplantation with an acceptable drug safety and patient tolerance.