bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Pembelajaran Interaktif Ilmu Pengetahuan Sosial Pada Smp Negeri 1 Carita
Authors: Nurhayati Sri 
Published: November 2020

Saat ini, pemanfaatan teknologi informasi sudah digunakan dalam bidang pendidikan. Komputer merupakan salah satu media yang dimanfaatkan sebagai alat bantu dalam sistem pembelajaran. Pembelajaran ilmu sosial adalah ilmu yang mempelajari ilmu-ilmu sosial berdasarkan fakta dan fenomena sosial. Selama ini, proses belajar mengajar untuk mata pelajaran IPS masih bersifat konvensional yaitu guru memberikan materti dari buku dan menggunakan metode ceramah tanpa alat peraga, hal ini disebabkan kurangnya alat peraga untuk mata pelajaran tersebut. Dari proses tersebut guru merasa kesulitan dan juga membutuhkan tenaga ekstra untuk menyampaikan materi ajar kepada siswa secara lisan sehingga pemahaman materi kepada siswa juga berkurang. Pada penelitian ini akan dibuat aplikasi pembelajaran interaktif untuk mata pelajaran IPS dengan menggunakan metode pengembangan aplikasi yaitu MDLC (Multimedia Development Life Cycle). Penelitian ini bertujuan untuk membuat aplikasi pembelajaran interaktif yang dapat digunakan sebagai alat bantu dalam proses pembelajaran IPS. Hasil penelitian menunjukkan bahwa secara fungsional aplikasi dapat digunakan, dan dapat meningkatkan minat belajar siswa serta membantu pemahaman mata pelajaran IPS. Kata kunci: Ilmu pengetahuan sosial, pembelajaran interaktif, Multimedia Development Life Cycle
Sistem Pendukung Keputusan Untuk Promosi Jabatan Menggunakan Metode SMART (Simple Multi Attribute Rating Technique)
Authors: Sunarti Sunarti 
Published: November 2020

Untuk meningkatkan kinerja karyawan salah satunya dilakukan promosi jabatan. Promosi jabatan pada Apartemen Senayan Jakarta dilakukan setiap setahun sekali. Alasan promosi jabatan melakukan evaluasi, menjaga kualitas kinerja karyawan, dan posisi jabatan tersebut sedang kosong. Promosi Jabatan karyawan dilakukan dengan memilih alternatif karyawan yang memenuhi persyaratan berdasarkan ketentuan kriteria. Kriteria yang digunakan adalah Pemahaman pekerjaan, kualitas pekerjaan, kreativitas, kemampuan, komunikasi, prestasi, kedisiplinan, kerjasama tim. Untuk promosi jabatan selama ini masih menggunakan konsep konvensional, sehingga proses pengambilan keputusan menjadi tidak sesuai dengan target. Banyaknya kriteria yang harus dilakukan, proses hitung serta tidak jelasnya pembobotan nilai mengakibatkan penilaian menjadi tidak objektif. Penelitian ini menggunakan metode SMART (Simple Multi Attribute Rating Technique),karena metode pengambilan keputusan untuk pemecah permasalahan dengan banyak kriteria. Tujuan dari penelitian memberikan pemecah permasalah dan direkomendasikan sebagai penentuan kinerja karyawan untuk promosi jabatan dan hasil yang diperoleh secara objektif. Hasil dari penelitian ini berupa keluaran yang direkomendasi nama karyawan yang dipromosikan bernilai 1,34 direkomendasikan untuk dipromoskan jabatan.
TONGAUNA SEBAGAI BARATA KERAJAAN KONAWE PADA MASA PEMERINTAHAN MOKOLE TEBAWO : 1602-1668
Authors: Anita Anita , Fatma Fatma , Khabiirun Khabiirun 
Published: November 2020

Peneitian ini bertujuan untuk mengetahui alasan terpilihnya Tongauna sebagai barata di kerajaan konawe di masa pemerintahan Mokole Tebawo. Serta, menjelaskan fungsi barata pada struktur pemerintaha. Penelitian ini menggunakan metode sejarah dengan melalui lima tahapan-tahapan kerja sebagai berikut (1) Pemilihan topik, (2) Pengumpulan sumber, (3) Kritik sumber, (4) Interpretasi sumber, (5) Historiografi. Hasil penelitian menunjukan bahwa (1) latar belakang Tongauna dan sebagai wilayah barata (a) Bermula dari pengelompokkan-pengelompokkan (O’Kambo) kampung yang dipimpin oleh seorang yang dituakan disebut Tono Mutou, dibantu oleh seorang Posudo, seorang Tolea seorang Mbuowai, seorang Mbusehe, seorang Tamalaki, dan Otudo. (b) Kelompok inilah yang kemudian berkembang membentuk sebuah wilayah kekuasaan (Kerajaan kecil) dan mereka mengangkat sebagai pemimpin dari kalangan mereka (Primus Inter Pares) pemimpin yang dapat melindungi kelompok, seorang Raja yang disebut “Mokolele” di beberapa wilayah. (c) (2) Fungsi Tongauna sebagai daerah barata di kerajaan konawe. (a) untuk menjaga keamanan dan pertahanan dari berbagai ancaman baik dari dalam maupun dari luar (b) agar tetap dalam persatuan maka Mokole Tebawo menyusun strategi politik pemerintahannya yang di sebut Siwole Mbatohu dan Pitu Dula Batu.
Patient related barriers to adequate blood pressure control among adult hypertensive patients seen at Kiambu County Hospital, Kenya
Authors: Kibore Antony Mogondo , Moturi George , Thigiti Joseph 
Published: November 2020

Introduction: Hypertension is a key precursor to cardiovascular and renal disease globally. According to WHO, Prevalence of hypertension was about 40 % globally in 2015 and 45% in Sub Saharan Africa in 2015. Despite much emphasis on treatment of the syndrome, the related blood pressure control remains poor or inadequate.
Objective: The study sought to establish the patient related barriers to adequate blood pressure control among adult hypertensive patients in Kiambu Count Hospital in Kenya.
Methods: A cross -sectional descriptive study method approach was used to examine sample of 330 patients selected through consecutive sampling technique in the medical outpatient chronic disease clinic. Multivariate logistic regression analysis was used to determine variables associated with inadequate or poorly controlled hypertension among adult patients.
Results: Most of the patients were females (71.5%). However, the presence of inadequate blood pressure control was significantly higher among males (P-value= 0.009). Regularly taking of hypertension drugs for the last 6 months was significantly associated with adequate blood pressure control (p-value=0.033). The other barriers including single status, inadequate knowledge, employment and time duration since diagnosis of hypertension did not significantly affect blood pressure control status.
Discussion: Males were 54% more likely to have inadequate blood pressure control compared to females (AOR=0.543; 95%CI=0.323-0.914). Patients with low adherence to treatment were 11% more likely to have inadequate blood pressure control than those with high adherence rate (AOR=1.093; 95%CI=0.224-5.332) though the association was not significant (p-value=0.912).
Conclusion: Male gender was a major barrier to adequate blood pressure control. Patients who well adhered to treatment scheme for a duration of six months preceding the study had their blood pressure better controlled than those who did not. Male hypertensive patients need to be followed up to ensure they adhere to drug treatment in order to reduce the rates of inadequate blood pressure control and other related complications.
GFOGER Peptide Modifies the Protein Content of Extracellular Vesicles and Inhibits Vascular Calcification
Authors: Mansour Ali , Darwiche Walaa , Yaker Linda , Da Nascimento Sophie , Gomila Cathy , Rossi Claire , Jung Vincent , Sonnet Pascal , Kamel Saïd , Guerrera Ida Chiara , Boullier Agnès , Ausseil Jérôme 
Published: November 2020

ObjectiveVascular calcification (VC) is an active process during which vascular smooth muscle cells (VSMCs) undergo an osteogenic switch and release extracellular vesicles (EVs). In turn, the EVs serve as calcification foci via interaction with type 1 collagen (COL1). We recently showed that a specific, six-amino-acid repeat (GFOGER) in the sequence of COL1 was involved in the latter’s interaction with integrins expressed on EVs. Our main objective was to test the GFOGER ability to inhibit VC.ApproachWe synthesized the GFOGER peptide and tested its ability to inhibit the inorganic phosphate (Pi)-induced calcification of VSMCs and aortic rings. Using mass spectrometry, we studied GFOGER’s effect on the protein composition of EVs released from Pi-treated VSMCs.ResultsCalcification of mouse VSMCs (MOVAS-1 cells), primary human VSMCs, and rat aortic rings was lower in the presence of GFOGER than with Pi alone (with relative decreases of 66, 58, and 91%, respectively; p &lt; 0.001 for all) (no effect was observed with the scramble peptide GOERFG). A comparative proteomic analysis of EVs released from MOVAS-1 cells in the presence or absence of Pi highlighted significant differences in EVs’ protein content. Interestingly, the expression of some of the EVs’ proteins involved in the calcification process (such as osteogenic markers, TANK-binding kinase 1, and casein kinase II) was diminished in the presence of GFOGER peptide (data are available via ProteomeXchange with identifier PXD018169∗). The decrease of osteogenic marker expression observed in the presence of GFOGER was confirmed by q-RT-PCR analysis.ConclusionGFOGER peptide reduces vascular calcification by modifying the protein content of the subsequently released EVs, in particular by decreasing osteogenicswitching in VSMCs.
Preliminary Evaluation of the Engagement and Effectiveness of a Mental Health Chatbot
Authors: Daley Kate , Hungerbuehler Ines , Cavanagh Kate , Claro Heloísa Garcia , Swinton Paul Alan , Kapps Michael 
Published: November 2020

Background: Mental health difficulties are highly prevalent, yet access to support is limited by barriers of stigma, cost, and availability. These issues are even more prevalent in low- and middle-income countries, and digital technology is one potential way to overcome these barriers. Digital mental health interventions are effective but often struggle with low engagement rates, particularly in the absence of human support. Chatbots could offer a scalable solution, simulating human support at a lower cost.Objective: To complete a preliminary evaluation of engagement and effectiveness of Vitalk, a mental health chatbot, at reducing anxiety, depression and stress.Methods: Real world data was analyzed from 3,629 Vitalk users who had completed the first phase of a Vitalk program (“less anxiety,” “less stress” or “better mood”). Programs were delivered through written conversation with a chatbot. Engagement was calculated from the number of responses sent to the chatbot divided by days in the program.Results: Users sent an average of 8.17 responses per day. For all three programs, target outcome scores reduced between baseline and follow up with large effect sizes for anxiety (Cohen's d = −0.85), depression (Cohen's d = −0.91) and stress (Cohen's d = −0.81). Increased engagement resulted in improved post-intervention values for anxiety and depression.Conclusion: This study highlights a chatbot's potential to reduce mental health symptoms in the general population within Brazil. While findings show promise, further research is required.
Complement C1q as a Potential Biomarker for Obesity and Metabolic Syndrome in Chinese Adolescents
Authors: Yang Xuelian , Ma Yanan , Zhao Zhongyi , Zhen Shihan , Wen Deliang 
Published: November 2020

BackgroundComplement C1q (C1q) has been confirmed to be related to obesity, metabolic syndrome (MetS), and its components. However, human data regarding the associations are relatively scarce. This study aimed to investigate associations of C1q with obesity as well as MetS in Chinese adolescents.MethodsA total of 1,191 Chinese adolescents aged 13–18 years were enrolled in this study. The biochemical and anthropometric variables of all the subjects were evaluated using standardized procedures. C1q was measured using the immunoturbidometric assay. The relationship between C1q and obesity or MetS was analyzed using multiple regression analyses.ResultsObesity was more prevalent among participants in the highest tertile than in the lowest tertile of C1q levels. The highest tertile of C1q was related to a greater effect on the risk of MetS, and its trend test was statistically significant. Except for hyperglycemia, the prevalence of other components of MetS significantly increased relative to an increase in C1q tertile. Receiver operating characteristic (ROC) curve analysis of C1q for predicting adolescents with MetS illustrated that the area under the curve (AUC) was 0.82 [95% confidence interval (CI): 0.76, 0.88; P&lt;0.001] in the total population after adjusting for confounders.ConclusionsThis study observed a significantly higher prevalence of obesity and MetS features in adolescents with high C1q. The findings of the current study also reported a significant relationship between C1q levels and MetS components [except for fasting plasma glucose (FPG)] in Chinese adolescents. C1q may represent a biomarker for predicting obesity or MetS in adolescents.
Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation
Authors: Muderrisoglu Ahmet , Babaoglu Elif , Korkmaz Elif Tugce , Ongun Mert C. , Karabulut Erdem , Iskit Alper B. , Emri Salih , Babaoglu Melih O. 
Published: November 2020

ObjectivesTo determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population.Methods130 smokers and 130 non-smokers were recruited. Individuals who never smoked were described as non-smokers. 130 smokers were treated with nicotine replacement therapy (NRT) (n = 40), bupropion (n = 47), bupropion + NRT (n = 15), and varenicline (n = 28). Smokers were checked by phone after 12 weeks of treatment whether they were able to quit smoking or not. Genotyping and phenotyping were performed.ResultsCessation rates were as follows; 20.0% for NRT, 29.8% for bupropion, 40.0% for bupropion + NRT, 57.1% for varenicline (p = 0.013). The frequency of ABCB1 1236TT-2677TT-3435TT haplotype was significantly higher in non-smokers as compared to smokers (21.5% vs. 10.8, respectively; p = 0.018). Neither smoking status nor smoking cessation rates were associated with genetic variants of CYP2A6 (p = 0.652, p = 0.328, respectively), or variants of CYP2B6 (p = 0.514, p = 0.779, respectively).ConclusionGenetic variants of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with non-smoking status. Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment.
Integrative Analysis of Genomics and Transcriptome Data to Identify Regulation Networks in Female Osteoporosis
Authors: Zhang Xianzuo , Chen Kun , Chen Xiaoxuan , Kourkoumelis Nikolaos , Li Guoyuan , Wang Bing , Zhu Chen 
Published: November 2020

Background: Osteoporosis is a highly heritable skeletal muscle disease. However, the genetic mechanisms mediating the pathogenesis of osteoporosis remain unclear. Accordingly, in this study, we aimed to clarify the transcriptional regulation and heritability underlying the onset of osteoporosis.Methods: Transcriptome gene expression data were obtained from the Gene Expression Omnibus database. Microarray data from peripheral blood monocytes of 73 Caucasian women with high and low bone mineral density (BMD) were analyzed. Differentially expressed messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) were identified. Differences in BMD were then attributed to several gene modules using weighted gene co-expression network analysis (WGCNA). LncRNA/mRNA regulatory networks were constructed based on the WGCNA and subjected to functional enrichment analysis.Results: In total, 3,355 mRNAs and 999 lncRNAs were identified as differentially expressed genes between patients with high and low BMD. The WGCNA yielded three gene modules, including 26 lncRNAs and 55 mRNAs as hub genes in the blue module, 36 lncRNAs and 31 mRNAs as hub genes in the turquoise module, and 56 mRNAs and 30 lncRNAs as hub genes in the brown module. JUN and ACSL5 were subsequently identified in the modular gene network. After functional pathway enrichment, 40 lncRNAs and 16 mRNAs were found to be related to differences in BMD. All three modules were enriched in metabolic pathways. Finally, mRNA/lncRNA/pathway networks were constructed using the identified regulatory networks of lncRNAs/mRNAs and pathway enrichment relationships.Conclusion: The mRNAs and lncRNAs identified in this WGCNA could be novel clinical targets in the diagnosis and management of osteoporosis. Our findings may help elucidate the complex interactions between transcripts and non-coding RNAs and provide novel perspectives on the regulatory mechanisms of osteoporosis.
Comparative Genomic Analyses Reveal a Specific Mutation Pattern Between Human Coronavirus SARS-CoV-2 and Bat-CoV RaTG13
Authors: Lv Longxian , Li Gaolei , Chen Jinhui , Liang Xinle , Li Yudong 
Published: November 2020

BackgroundThe outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, rapidly grew into a global pandemic. How SARS-CoV-2 evolved remains unclear.MethodsWe performed a comprehensive analysis using the available genomes of SARS-CoV-2 and its closely related coronaviruses.ResultsThe ratio of nucleotide substitutions to amino acid substitutions of the spike gene (9.07) between SARS-CoV-2 WIV04 and Bat-CoV RaTG13 was markedly higher than that between other coronaviruses (range, 1.29–4.81); the ratio of non-synonymous to synonymous substitution rates (dN/dS) between SARS-CoV-2 WIV04 and Bat-CoV RaTG13 was the lowest among all the performed comparisons, suggesting evolution under stringent selective pressure. Notably, the relative proportion of the T:C transition was markedly higher between SARS-CoV-2 WIV04 and Bat-CoV RaTG13 than between other compared coronaviruses. Codon usage is similar across these coronaviruses and is unlikely to explain the increased number of synonymous mutations. Moreover, some sites of the spike protein might be subjected to positive selection.ConclusionsOur results showed an increased proportion of synonymous substitutions and the T:C transition between SARS-CoV-2 and RaTG13. Further investigation of the mutation pattern mechanism would contribute to understanding viral pathogenicity and its adaptation to hosts.
Hydrogen Sulfide Overproduction Is Involved in Acute Ischemic Cerebral Injury Under Hyperhomocysteinemia
Authors: Ji Yan , Li Yusheng , Zhao Zichen , Li Panxing , Xie Yi 
Published: November 2020

ObjectivesThis study aimed to identify the involvement of hydrogen sulfide overproduction in acute brain injury under ischemia/reperfusion and hyperhomocysteinemia.MethodsIn vitro and in vivo experiments were conducted to determine: the effect of sodium hydrosulfide treatment on the human neuroblastoma cell line (SH-SY5Y) under conditions of oxygen and glucose deprivation; the changes of hydrogen sulfide levels, inflammatory factors, energetic metabolism, and mitochondrial function in the brain tissue of rats under either ischemia/reperfusion alone or a combination of ischemia/reperfusion and hyperhomocysteinemia; and the potential mechanism underlying the relationship between homocysteine and these changes through the addition of the related inhibitors. Furthermore, experimental technologies, including western blot, enzyme-linked immunosorbent assay, immunofluorescence, reverse transcription polymerase chain reaction, and flow cytometry, were used.ResultsOur study found that high concentration of sodium hydrosulfide treatment aggravated the decrease in mitochondrial membrane potential, the increase in both mitochondrial permeability transition pore and translocation of cytochrome C, as well as the accumulation of reactive oxygen species in oxygen and glucose deprived SH-SY5Y cells. As a result, neurological deficit appeared in rats with ischemia/reperfusion or ischemia/reperfusion and hyperhomocysteinemia, and a higher water content and larger infarction size of cerebral tissue appeared in rats combined ischemia/reperfusion and hyperhomocysteinemia. Furthermore, alterations in hydrogen sulfide production, inflammatory factors, and mitochondria morphology and function were more evident under the combined ischemia/reperfusion and hyperhomocysteinemia. These changes were, however, alleviated by the addition of inhibitors for CBS, CSE, Hcy, H2S, and NF-κB, although at different levels. Finally, we observed a negative relationship between the blockage of: (a) the nuclear factor kappa-B pathway and the levels of cystathionine β-synthase and hydrogen sulfide; and (b) the hydrogen sulfide pathway and the levels of inflammatory factors.ConclusionHydrogen sulfide overproduction and reactive inflammatory response are involved in ischemic cerebral injury under hyperhomocysteinemia. Future studies in this direction are warranted to provide a scientific base for targeted medicine development.
Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer’s Disease
Authors: Morris Jill K. , John Casey S. , Green Zachary D. , Wilkins Heather M. , Wang Xiaowan , Kamat Ashwini , Swerdlow Russell S. , Vidoni Eric D. , Petersen Melissa E. , O’Bryant Sid E. , Honea Robyn A. , Burns Jeffrey M. 
Published: November 2020

BackgroundIndividuals with Alzheimer’s Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect insulin secretion and food intake, remains less clear.MethodsHere, we leveraged a physiologically relevant meal tolerance test to assess diagnostic differences in these metabolic responses in cognitively healthy older adults (CH; n = 32) and AD (n = 23) participants. All individuals also underwent a comprehensive clinical examination, cognitive evaluation, and structural magnetic resonance imaging.ResultsThe meal-stimulated response of glucose, insulin, and peptide tyrosine tyrosine (PYY) was significantly greater in individuals with AD as compared to CH. Voxel-based morphometry revealed negative relationships between brain volume and the meal-stimulated response of insulin, C-Peptide, and glucose-dependent insulinotropic polypeptide (GIP) in primarily parietal brain regions.ConclusionOur findings are consistent with prior work that shows differences in metabolic regulation in AD and relationships with cognition and brain structure.