bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stratigraphic hierarchy and three‐dimensional evolution of an exhumed submarine slope channel system
Authors: Bell Daniel , Hodgson David M. , Pontén Anna S. M. , Hansen Larissa A. S. , Flint Stephen S. , Kane Ian A. 
Published: April 2020

AbstractSubmarine slope channel systems have complicated three‐dimensional geometries and facies distributions, which are challenging to resolve using subsurface data. Outcrop analogues can provide sub‐seismic‐scale detail, although most exhumed systems only afford two‐dimensional constraints on the depositional architecture. A rare example of an accessible fine‐grained slope channel complex set situated in a tectonically quiescent basin that offers seismic‐scale, down‐dip and across‐strike exposures is the Klein Hangklip area, Tanqua‐Karoo Basin, South Africa. This study investigates the three‐dimensional architecture of this channel complex set to characterise the stratigraphic evolution of a submarine channel‐fill and the implications this has for both sediment transport to the deep‐oceans and reservoir quality distribution. Correlated sedimentary logs and mapping of key surfaces across a 3 km2 area reveal that: (i) the oldest channel elements in channel complexes infill relatively deep channel cuts and have low aspect‐ratios. Later channel elements are bound by comparatively flat erosion surfaces and have high aspect‐ratios; (ii) facies changes across depositional strike are consistent and predictable; conversely, facies change in successive down depositional dip positions indicating longitudinal variability in depositional processes; (iii) stratigraphic architecture is consistent and predictable at seismic‐scale both down‐dip and across‐strike in three‐dimensions; (iv) channel‐base‐deposits exhibit spatial heterogeneity on one to hundreds of metres length‐scales, which can inhibit accurate recognition and interpretations drawn from one‐dimensional or limited two‐dimensional datasets; and (v) channel‐base‐deposit character is linked to sediment bypass magnitude and longevity, which suggests that time‐partitioning is biased towards conduit excavation and maintenance rather than the fill‐phase. The data provide insights into the stratigraphic evolution and architecture of slope channel‐fills on fine‐grained continental margins and can be utilised to improve predictions derived from lower resolution and one‐dimensional well data.
The upper Miocene diatomaceous sediments of the northernmost Mediterranean region: A lamina‐scale investigation of an overlooked palaeoceanographic archive
Authors: Pellegrino Luca , Dela Pierre Francesco , Jordan Richard W. , Abe Kenta , Mikami Yuta , Natalicchio Marcello , Gennari Rocco , Lozar Francesca , Carnevale Giorgio 
Published: April 2020

AbstractDuring the late Miocene the Mediterranean experienced a dramatic intensification of opaline accumulation, recorded by the deposition of diatomaceous sediments. The fine lamination of these deposits potentially records annual to sub‐annual palaeoceanographic processes that occurred during a critical phase of the geodynamic evolution of the Mediterranean basin, which eventually led to the Messinian salinity crisis. The diatomaceous facies has been interpreted by previous researchers as the product of intensified upwelling currents and of bottom anoxia formation in the Mediterranean basin. However, until now, no efforts have been made to unravel the sedimentological and micropalaeontological content of these deposits at the lamina‐scale. This paper presents the first case study of a systematic scanning electron microscope‐based morphological investigation of the diatomaceous sediments deposited during the late Miocene at the northernmost offshoot of the Mediterranean basin (Piedmont Basin, north‐west Italy). Using a non‐invasive analytical approach, six faciological components (laminae, laminated packets, non‐laminated intervals, burrows, opal‐rich aggregates and mixed pelletal structures) and their relationships are described and interpreted herein. Following the lamina‐scale study of these sediments, an annual sedimentary cycle could be identified and an accumulation rate (ca 50 cm kyr−1) inferred that is atypical for a setting actively influenced by upwelling. The role played by the entanglement of diatom valves in creating a physical barrier to the bioturbation is here emphasized as the main process responsible for the preservation of the laminated fabric of diatomaceous sediments, challenging the supposed role of deep anoxia. These results suggest that the late Miocene diatomaceous deposition in the Piedmont Basin cannot be univocally considered as a by‐product of upwelling intensification and seafloor oxygen depletion.
The use of aluminium hydroxide as adjuvant modulates the specific antibody response—A Brown Norway rat study with native and denatured cow's milk allergens
Authors: Bøgh Katrine Lindholm , Andreasen Mie Scharff , Madsen Charlotte Bernhard 
Published: April 2020

AbstractThere is a need for efficient methods to treat food allergy; however, no immunotherapeutic method has yet been satisfactory due to the high rate of unpredictable severe reactions and the limited efficacy. Therefore, modified versions of food allergens have been suggested as alternatives to the parent proteins for immunotherapy. The aim of the study was to compare the inherent allergenicity of the native and denatured version of the cow's milk proteins β‐lactoglobulin and α‐lactalbumin, and to study the impact of the use of Al(OH)3 as an adjuvant. Brown Norway rats were immunized intraperitoneally with either native or denatured β‐lactoglobulin or α‐lactalbumin, with or without the use of Al(OH)3 as adjuvant. Antibody responses were analysed in various ways by means of different ELISAs. Both the immunogenicity and the sensitizing capacity of the cow's milk allergens were influenced by their globular folding, with the native version being more allergenic than the denatured counterpart. The native folded proteins mainly raised antibodies against conformational epitope, whereas the denatured versions predominantly raised antibodies against linear epitopes. Most interestingly, the study showed that the use of Al(OH)3, besides increasing immunogenicity and sensitizing capacity of the cow's milk allergens, caused a modification of the specificity of the antibodies raised against the native version of the proteins. Adsorption of the native forms of the allergens to Al(OH)3 caused a significant greater proportion of antibodies raised against linear epitopes, stressing that the adsorption induced a partly unfolding of the proteins. This may have implications for IT safety and efficacy.
Frequency and classification of errors in laboratory medicine at a veterinary teaching hospital in the United States
Authors: Whipple Kellie M. , Leissinger Mary K. , Beatty Sarah S. 
Published: April 2020

AbstractBackgroundThe accuracy of laboratory data is of utmost importance. Data regarding laboratory error in human laboratories are often extrapolated into veterinary settings. One study investigated the rate and type of errors in a European commercial veterinary laboratory, but that data might not directly apply to an educational setting.ObjectivesThis study determined the frequency and type of errors in laboratory medicine at a veterinary teaching hospital.MethodsErrors associated with clinical pathology samples were recorded over two 60‐day periods. The first period included a time when new students and house officers started at the veterinary school. The second time period was 6 months later. The errors were assigned to categories, and the frequency of each was calculated. Sample hemolysis, icterus, and lipemia were evaluated separately using an automated index, as these conditions could be pathologic or the result of error. Frequencies of error and hemolysis, icterus, and lipemia were assessed between the groups.ResultsTotal error rates were 4.7% and 3.5% for the first and second periods, respectively. The frequency of each error subclassification was similar to those observed in the veterinary and human literature, with preanalytic error predominating. Statistically significant differences in the overall error rate and percentage of preanalytic errors that occurred outside of and within the laboratory were observed comparing differences between the two periods.ConclusionsThe overall error rate in this veterinary teaching hospital was slightly higher than that previously reported in other settings, although a proportion of errors was as expected. Areas needing improvement were identified, and strategies to reduce error could be developed.
Isotope sclerochronology indicates enhanced seasonal precipitation in northern South America (Colombia) during the Mid-Miocene Climatic Optimum
Authors: Scholz Serena R. , Petersen Sierra V. , Escobar Jaime , Jaramillo Carlos , Hendy Austin J.W. , Allmon Warren D. , Curtis Jason H. , Anderson Brendan M. , Hoyos Natalia , Restrepo Juan C. , Perez Nicolas 
Published: April 2020

Abstract
During the Mid-Miocene Climatic Optimum (MMCO, 14.7–17.3 Ma), global temperatures were warmer than present, and similar to predicted temperatures for the coming century. Limited paleoclimate data exist from the tropics during this period, despite its potential as an analog for future climate conditions. This study presents new subannual stable isotope data (δ18O and δ13C) from a large population of Miocene Turritella gastropods from the Jimol and Castilletes Formations of the Guajira Peninsula, Colombia. Turritellids are aragonitic marine mollusks that live in shallow coastal waters, and their rapid growth rates allow for high-resolution subannual records. We compare these fossils to modern Turritella gastropods from multiple tropical localities to reconstruct subannual climate conditions. The seasonal range in δ18O in the modern shells correlates with the seasonal variance of local precipitation, once temperature seasonality is accounted for. The Miocene fossils show larger (in some cases &gt;2‰) seasonal variation in δ18O than modern Turritella from the same location, suggesting increased seasonality of precipitation in Miocene northern Colombia relative to today. We propose that this increased seasonality of precipitation was due to a more northerly position of the Intertropical Convergence Zone during the mid-Miocene. The resulting wet Miocene paleoenvironment is in stark contrast to semiarid conditions on the Guajira Peninsula today, indicating that this area of tropical South America has undergone a drastic environmental change since the Miocene.
Tidal modulation of river-flood deposits: How low can you go?
Authors: Maselli Vittorio , Normandeau Alexandre , Nones Michael , Tesi Tommaso , Langone Leonardo , Trincardi Fabio , Bohacs Kevin M. 
Published: April 2020

Abstract
Quantification of the interaction between river discharge and tides is vital to characterize fluvio-deltaic systems, to identify diagnostic elements of tidal signatures in the rock record, and to reconstruct paleogeographies. In modern systems, even microtides can significantly influence delta morphodynamics; yet, many fundamental processes, particularly in prodeltaic settings, remain elusive. Here, by combining a unique process-product data set acquired during a flood event of the Po River (Italy) with numerical modeling, we show that tidal signatures are recorded in the open-water prodelta zone of a microtidal system. Based on the analyses of box-cores collected before and after a flood off the main distributary channel, we interpreted storm beds, tide-modulated flood strata of alternating normal and inverse graded beds, and rapid bioturbation. Modeling of the river discharge indicates that, at the peak of the flood, the steepening of the water-surface profile forced by 0.15 m lowering of sea level during low tides generated an 8% increase in river flow velocity. The alternation of profile steepness and associated cyclicity in flow strength during consecutive tidal cycles controlled the sediment load of the plume and, consequently, led to the deposition of tidal-modulated strata. Formation of microtidal signals appears to be enhanced in fluvio-deltaic successions characterized by multiple distributaries and in basins where river floods are out of phase with storm-wave activity. Bioturbation of sediment, which can start during the waning stage of the flow, and erosion by storm waves hamper the preservation of tidal signals, unless rapid burial occurs. The recognition of tidal-modulated strata in river-dominated settings may facilitate the characterization of mudstone reservoirs and reconstruction of paleogeographic conditions during deposition.
Long-term outcomes of treat-and-extend ranibizumab with and without navigated laser for diabetic macular oedema: TREX-DME 3-year results
Authors: Payne John F. , Wykoff Charles C. , Clark W. Lloyd , Bruce Beau B. , Boyer David S. , Brown David M. 
Published: April 2020

Background/aimsTo evaluate the long-term effects of treat-and-extend dosing of ranibizumab with and without navigated focal laser for diabetic macular oedema (DME).MethodsThis is a multicentre, randomised clinical trial where 150 eyes were randomised into three cohorts; Monthly (n=30), TReat and EXtend without macular laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded macular LAser photocoagulation (GILA; n=60). During the first 2 years, eyes either received ranibizumab 0.3 mg every 4 weeks or underwent treat-and-extend ranibizumab with or without angiography-guided laser therapy. In the third year, all eyes were treated as needed with ranibizumab for >5 letters vision loss or if the central retinal thickness (CRT) was >325 µm, and all eyes were eligible to receive focal laser.Results109 eyes (73%) completed the 3-year end-point. At week 156, mean best-corrected visual acuity (BCVA) and CRT improved by 6.9, 9.7, 9.5 letters (p=0.60) and 129, 138, 165 µm (p=0.39), in the Monthly, TREX and GILA cohorts, respectively. These improvements were reached prior to week 104 and no significant changes occurred from week 104 to week 156 (BCVA: p=0.34; CRT: p=0.36). The mean number of injections in the third year was 3.0, 3.1, and 2.4 in the Monthly, TREX and GILA cohorts, respectively (p=0.56). 86 eyes (79%) required at least one ranibizumab injection in the third year.ConclusionThe improvements achieved after 2 years of treat-and-extend ranibizumab for DME were maintained in the third year with a mean of 3 intravitreal injections.Trial registration numberFDA IND 119146, NCT01934556.
How to manage travel fatigue and jet lag in athletes? A systematic review of interventions
Authors: Janse van Rensburg Dina C(Christa) , Jansen van Rensburg Audrey , Fowler Peter , Fullagar Hugh , Stevens David , Halson Shona , Bender Amy , Vincent Grace , Claassen-Smithers Amanda , Dunican Ian , Roach Gregory Daniel , Sargent Charli , Lastella Michele , Cronje Tanita 
Published: April 2020

Objectives
We investigated the management of travel fatigue and jet lag in athlete populations by evaluating studies that have applied non-pharmacological interventions (exercise, sleep, light and nutrition), and pharmacological interventions (melatonin, sedatives, stimulants, melatonin analogues, glucocorticoids and antihistamines) following long-haul transmeridian travel-based, or laboratory-based circadian system phase-shifts.

Design
Systematic review

Eligibility criteria

Randomised controlled trials (RCTs), and non-RCTs including experimental studies and observational studies, exploring interventions to manage travel fatigue and jet lag involving actual travel-based or laboratory-based phase-shifts. Studies included participants who were athletes, except for interventions rendering no athlete studies, then the search was expanded to include studies on healthy populations.

Data sources
Electronic searches in PubMed, MEDLINE, CINAHL, Google Scholar and SPORTDiscus from inception to March 2019. We assessed included articles for risk of bias, methodological quality, level of evidence and quality of evidence.

Results
Twenty-two articles were included: 8 non-RCTs and 14 RCTs. No relevant travel fatigue papers were found. For jet lag, only 12 athlete-specific studies were available (six non-RCTs, six RCTs). In total (athletes and healthy populations), 11 non-pharmacological studies (participants 600; intervention group 290; four non-RCTs, seven RCTs) and 11 pharmacological studies (participants 1202; intervention group 870; four non-RCTs, seven RCTs) were included. For non-pharmacological interventions, seven studies across interventions related to actual travel and four to simulated travel. For pharmacological interventions, eight studies were based on actual travel and three on simulated travel.

Conclusions
We found no literature pertaining to the management of travel fatigue. Evidence for the successful management of jet lag in athletes was of low quality. More field-based studies specifically on athlete populations are required with a multifaceted approach, better design and implementation to draw valid conclusions.

PROSPERO registration number

The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO: CRD42019126852).
Policy dialogue as a collaborative tool for multistakeholder health governance: a scoping study
Authors: Robert Emilie , Rajan Dheepa , Koch Kira , Muggleworth Weaver Alyssa , Porignon Denis , Ridde Valery 
Published: April 2020

IntroductionHealth system governance is the cornerstone of performant, equitable and sustainable health systems aiming towards universal health coverage. Global health actors have increasingly been using policy dialogue (PD) as a governance tool to engage with both state and non-state stakeholders. Despite attempts to frame PD practices, it remains a catch-all term for both health systems professionals and researchers.MethodWe conducted a scoping study on PD. We identified 25 articles published in English between 1985 and 2017 and 10 grey literature publications. The analysis was guided by the following questions: (1) How do the authors define PD? (2) What do we learn about PD practices and implementation factors? (3) What are the specificities of PD in low-income and middle-income countries?ResultsThe analysis highlighted three definitions of policy dialogue: a knowledge exchange and translation platform, a mode of governance and an instrument for negotiating international development aid. Success factors include the participants’ continued and sustained engagement throughout all the relevant stages, their ability to make a constructive contribution to the discussions while being truly representative of their organisation and their high interest and stake in the subject. Prerequisites to ensuring that participants remained engaged were a clear process, a shared understanding of the goals at all levels of the PD and a PD approach consistent with the PD objective. In the context of development aid, the main challenges lie in the balance of power between stakeholders, the organisational or technical capacity of recipient country stakeholders to drive or contribute effectively to the PD processes and the increasingly technocratic nature of PD.ConclusionPD requires a high level of collaborative governance expertise and needs constant, although not necessarily high, financial support. These conditions are crucial to make it a real driver of health system reform in countries’ paths towards universal health coverage.
Obstetrical safety indicators for preventing hospital harms in low risk births: a scoping review protocol
Authors: Conway Aislinn , Reszel Jessica , Walker Mark C , Grimshaw Jeremy M , Dunn Sandra I 
Published: April 2020

IntroductionOptimising the safety of obstetric patient care is a primary concern for many hospitals. Performance indicators measuring aspects of patient care processes can lead to improvements in health systems and the prevention of harm to the patient. We present our protocol for a scoping review to identify indicators for obstetric safety in low risk births. We aim to identify indicators addressing preventable hospital harms, to summarise the data and synthesise results.Methods and analysisWe will use methods described by Arksey and O’Malley and further expanded by Levacet al. We will search electronic databases such as Medline, Embase, CINAHL and the Cochrane Library, and websites from professional bodies and other organisations, using an iterative search strategy.Two reviewers will independently screen titles and abstracts of search results to determine eligibility for inclusion. If eligibility is not clear, the reviewers will screen the full text version. If reviewers’ decisions regarding eligibility differ, a third reviewer will review the record. Two reviewers will independently extract data from records that meet our inclusion criteria using a standardised data collection form. We will narratively describe quantitative data, such as the frequency with which indicators are identified, and conduct a thematic analysis of the qualitative data. We will compile a comprehensive list of patient safety indicators and organise them according to concepts that best suit the data such as the Donabedian model or the Hospital Harm Framework. We will discuss the implications for future research, clinical practice and policy-making. We will report the conduct of the review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews checklist.Ethics and disseminationThe sources of information included in this scoping review will be available to the public. Therefore, ethics approval is not warranted. We will disseminate results in a peer-reviewed publication, conference/event presentation(s) and stakeholder communications.
Gamma-glutamyl transferase variability and the risk of hospitalisation for heart failure
Authors: Hong So-hyeon , Lee Ji Sung , Kim Jung A , Lee You-Bin , Roh Eun , Yu Ji Hee , Kim Nam Hoon , Yoo Hye Jin , Seo Ji A , Kim Sin Gon , Kim Nan Hee , Baik Sei Hyun , Choi Kyung Mook 
Published: April 2020

ObjectiveGamma-glutamyl transferase (GGT) is associated with oxidative stress, inflammation, cardiovascular disease and mortality. Variability in metabolic parameters has recently emerged as an indicator of adverse health outcomes, including heart failure (HF).MethodsWe investigated whether GGT variability was associated with the incidence of hospitalisation for heart failure (HHF) in a Korean population without previous HF, ischaemic heart disease or liver disease. This longitudinal cohort study analysed 119 201 individuals from the Korean National Health Insurance Service-National Health Screening Cohort. GGT variability was calculated as the coefficient of variation (CV), SD and variability independent of the mean (VIM).ResultsDuring the 8.4 years of follow-up, 1387 cases of HHF (1.16%) developed. In the multivariable-adjusted model, the HR of HHF was 1.22 (95% CI 1.05 to 1.42) in the highest quartile of GGT variability compared with the lowest quartile, as assessed by CV after adjusting for confounding factors, including alcohol consumption and mean GGT levels. Consistent results were obtained using other indices of GGT variability such as SD (HR 1.37, 95% CI 1.16 to 1.62) and VIM (HR 1.29, 95% CI 1.11 to 1.50). In a subgroup analysis stratified by risk factor variables, although a similar relationship was observed, it was more prominent in individuals with dyslipidaemia.ConclusionsThe results of the present study demonstrated that variability in GGT was independently associated with the incidence of HHF. These findings suggest that higher GGT variability may be useful as an indicator of future risk of HF.