bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of percutaneous coronary intervention for chronic total occlusions in the elderly: A systematic review and meta‐analysis
Authors: Cui Chenmin , Sheng Zhichao 
Published: December 2020

AbstractObjectiveThis study aimed to compare outcomes of percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) in the elderly (≥75 years) versus nonelderly and assess the impact of successful CTO‐PCI in the elderly.MethodsPubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar databases were searched up to October 1, 2020. Mortality rates and major adverse cardiac events (MACE) were compared between elderly and nonelderly patients and successful versus failed CTO‐PCI in the elderly.ResultsEight studies were included. Meta‐analysis indicated no statistically significant difference in the risk of in‐hospital mortality (RR: 1.97 95% CI: 0.78, 4.96 I2 = 0% p = .15) but higher tendency of in‐hospital MACE (RR: 2.30 95% CI: 0.99, 5.35 I2 = 49% p = .05) in the elderly group. Risk of long‐term mortality (RR: 3.79 95% CI: 2.84, 5.04 I2 = 41% p < .00001) and long‐term MACE (RR: 1.53 95% CI: 1.14, 2.04 I2 = 80% p = .004) were significantly increased in the elderly versus nonelderly. Elderly patients had a significantly reduced odds of successful PCI as compared to nonelderly patients (OR: 0.63 95% CI: 0.54, 0.73 I2 = 1% p < .00001). Successful CTO‐PCI was associated with reduction in long‐term mortality (HR: 0.51 95% CI: 0.34, 0.77 I2 = 27% p = .001) and MACE (HR: 0.60 95% CI: 0.37, 0.97 I2 = 53% p = .04) as compared to failed PCI in elderly.ConclusionsElderly patients may have a tendency of higher in‐hospital MACE with significantly increased long‐term mortality and MACE after CTO‐PCI. The success of PCI is significantly lower in the elderly. In elderly patients with successful PCI, the risk of long‐term mortality and MACE is significantly reduced.
Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability
Authors: Knapinska Anna M. , Singh Chandani , Drotleff Gary , Blanco Daniela , Chai Cedric , Schwab Jason , Herd Anu , Fields Gregg B. 
Published: December 2020

AbstractMatrix metalloproteinase 13 (MMP‐13) activity has been correlated to breast cancer bone metastasis. It has been proposed that MMP‐13 contributes to bone metastasis through the promotion of osteoclastogenesis. To explore the mechanisms of MMP‐13 action, we previously described a highly efficacious and selective MMP‐13 inhibitor, RF036. Unfortunately, further pursuit of RF036 as a probe of MMP‐13 in vitro and in vivo activities was not practical due to the limited solubility and stability of the inhibitor. Our new study has explored replacing the RF036 backbone sulfur atom and terminal methyl group to create inhibitors with more favorable pharmacokinetic properties. One compound, designated inhibitor 3, in which the backbone sulfur and terminal methyl group of RF036 were replaced by nitrogen and oxetane, respectively, had comparable activity, selectivity, and membrane permeability to RF036, while exhibiting greatly enhanced solubility and stability. Inhibitor 3 effectively inhibited MMP‐13‐mediated osteoclastogenesis but spared collagenolysis, and thus represents a next‐generation MMP‐13 probe applicable for in vivo studies of breast cancer metastasis.
Multi‐view frontal face image generation: A survey
Authors: Ning Xin , Nan Fangzhe , Xu Shaohui , Yu Lina , Zhang Liping 
Published: December 2020

AbstractFace images from different perspectives reduce the accuracy of face recognition, and the generation of frontal face images is an important research topic in the field of face recognition. To understand the development of frontal face generation models and grasp the current research hotspots and trends, existing methods based on 3D models, deep learning, and hybrid models are summarized, and the current commonly used face generation methods are introduced. Dataset, and compare the performance of existing models through experiments. The purpose of this paper is to fundamentally understand the advantages of existing frontal face generation, sort out the key issues of such generation, and look toward future development trends.
Change in personality traits and facets (Revised NEO Personality Inventory) following metacognitive therapy or cognitive behaviour therapy for generalized anxiety disorder: Results from a randomized controlled trial
Authors: Kennair Leif Edward Ottesen , Solem Stian , Hagen Roger , Havnen Audun , Nysæter Tor Erik , Hjemdal Odin 
Published: December 2020

ObjectiveWe aimed to discover whether psychological treatment for generalized anxiety disorder (GAD) was associated with changes in the big five personality traits and their facets.MethodPatients with GAD were randomized either to receive cognitive behaviour therapy (CBT, n = 28) or metacognitive therapy (MCT, n = 32). Before and after 12 sessions of treatment, 55 of the patients completed the full Revised NEO Personality Inventory (NEO‐PI‐R) (240 items).ResultsPatients with GAD showed a personality profile with high Neuroticism and lower Extraversion and Openness. Treatment across conditions was associated with significant reduction in Neuroticism and increased Extraversion and Openness. There were no significant changes in Agreeableness and Conscientiousness. However, their facets of Actions and Trust increased. Post‐treatment levels of neuroticism were associated with symptoms of worry before and after therapy, whereas post‐treatment extraversion was related to depressive symptoms after treatment. MCT was associated with greater reduction of Neuroticism than CBT.ConclusionsThis is the first study to show that efficient treatment for a specific disorder resulted in changes across NEO‐PI‐R factors and facets and that more efficient treatment results in greater change. If this reflects a reduced trait vulnerability for mental disorder, this might provide evidence of relapse prevention.
Aneuploidy detection for diagnostic and prognostic use in premalignant and malignant lesions of the uterine cervix: A systematic review
Authors: Costa Ane Francyne , Ribeiro Mariana Goveia Melo , Onofre Alexandre Sherlley Casimiro , de Miranda Onofre Fabiana Botelho 
Published: December 2020

AbstractObjectiveTo systematically review the role of aneuploidy detection alone or in combination with other methods in cervical cancer screening and to evaluate the value of aneuploidy to predict the behavior of premalignant cervical lesions.MethodWe conducted a systematic review based on an electronic search for articles published between 2001 and 2020 across databases including MEDLINE/PubMed, Scopus, and Web of Science. Studies were subjected to data extraction, risk of bias, and narrative synthesis.ResultsA total of 15 articles were included in the review. Eight out of 15 studies (53.3%) were judged to be at a high or unclear risk of bias. From the 15 included studies, the index test to detect aneuploidy was DNA image cytometry (DNA‐ICM) in 12 studies and DNA flow cytometry (DNA‐FCM) in three studies. Nine studies also evaluated the performance of cytology and/or human papillomavirus (HPV) tests. For DNA‐ICM, sensitivity to detect cervical intraepithelial neoplasia or worse (CIN2+) varied between 59.0% and 95.9% and specificity varied between 54.1% and 100%. For DNA‐FCM, sensitivity varied between 27.3% to 96.8% and specificity was 100%. For cytological evaluation, sensitivity varied between 25.0% and 70.4% and specificity varied between 70.6% and 99.9%. For HPV detection, sensitivity varied between 39.4% and 100% and specificity varied between 23.3% and 84.3%.ConclusionDNA ploidy along with atypical cells findings in cytology and/or HPV detection revealed great value to detect CIN2+ lesions and to predict which lesions are more likely to progress to cervical cancer.
The introduction of treatment and the cultural adaptability of western psychotherapies for eating disorders in China
Authors: Chen Jue , Guo Lei , Gu Lian , Han Hui 
Published: December 2020

AbstractIn the past 40 years, the prevalence of eating disorders (ED) in China has shown an increasing trend, leading to an urgent need to develop efficient treatment modes and methods. Since the beginning of the new century, the diagnosis, treatment, and research of ED in China have been under development. This article gives an introduction and commentary on the treatment modes, treatment methods and their applications in ED in China. There are two main treatment forms for ED until now, that is, inpatient treatment and outpatient treatment. Inpatient treatment is recommended as the first choice. Since 2008, clinical psychotherapies such as cognitive behavioral therapy (CBT), dialectical behavioral therapy (DBT), and family‐based treatment (FBT), which are effective for pathological symptoms of ED, have been introduced into China and developed clinically. Group CBT and group DBT for patients with ED and group FBT for caregivers might be the most efficient psychotherapy in China nowadays. A multi‐family FBT support group could be developed as the basic treatment of ED patients. Although these new types of psychotherapy have observed effectiveness in clinical application, the Randomized Controlled Trials (RCT) are rare and need to be developed.
The changing profile of eating disorders and related sociocultural factors in Japan between 1700 and 2020: A systematic scoping review
Authors: Nakai Yoshikatsu , Nin Kazuko , Goel Neha J. 
Published: December 2020

AbstractObjectiveThe purpose of this study was to investigate the changing profile of the phenotypic expression of eating disorders (EDs) and related sociocultural factors in Japan between 1700 and 2020.MethodThe authors conducted a systematic scoping review in accordance with the PRISMA statement guidelines for scoping reviews.ResultsFindings indicate that Kampo doctors reported more than 50 patients with restrictive EDs in the 1700s, when Japan adopted a national isolation policy. On the other hand, only a few reports of EDs were found between 1868 and 1944, when rapid Westernization occurred. After World War II, providers began diagnosing patients with anorexia nervosa (AN) around 1960. Patients reported experiencing fat phobia, but did not engage in restriction for achieving slimness. However, after the 1970s, Japan experienced a rise in patients with AN who engaged in restriction to achieve thinness. Cases of patients who engaged in binge/purge symptomatology increased after the 1980s, followed by a steady increase in total ED cases after the 1990s. At various time points, providers attributed family conflicts, internalization of a thin ideal of beauty, changing food environments, and pressures associated with traditional gender roles to the onset and maintenance of EDs in Japan.DiscussionFindings reveal that restrictive EDs were present as early as the 18th century; Japanese patients may present with both “typical” and “atypical” forms of AN; ED symptoms can persist in the absence of Western influence; and sociocultural factors, such as gender‐specific stressors and family dynamics, may contribute to EDs for Japanese populations.
A single‐case multiple baseline design for treating insomnia in eating disorders: The TIRED study
Authors: Christensen Kara A. , Forbush Kelsie T. , Elliott Brendon T. , Jarmolowicz David P. 
Published: December 2020

AbstractObjectiveThe purpose of this trial is to evaluate the novel use of an empirically supported treatment for sleep problems for people with residual insomnia disorder following ED treatment.MethodParticipants (N = 6) will complete a single‐case multiple baseline study using Brief Behavioral Treatment for Insomnia (Buysse et al., Archives of Internal Medicine, 171, 2011, 887–895; Troxel et al., Behavioral Sleep Medicine, 10, 2012, 266–279). Participants will complete pre‐ and post‐treatment evaluations of insomnia severity, sleep efficiency, daytime fatigue, ED symptoms, depressive symptoms, and anxiety symptoms. Throughout treatment, participants will complete daily diaries of sleep indices (sleep latency, wake after sleep onset, total sleep time, and sleep efficiency).ResultsThe primary outcome will be treatment effects on insomnia severity, measured by the Insomnia Severity Index. Secondary outcomes include sleep efficiency and daytime fatigue. Exploratory outcomes include ED‐related impairment and symptoms, anxiety symptoms, and depression symptoms. We will provide subject‐level graphs of sleep indices and ED symptoms throughout treatment. Additionally, treatment effects will be examined at one‐ and three‐month follow‐up.DiscussionAlthough insomnia treatments have been evaluated in other psychiatric disorders, there has yet to be a study examining behavioral interventions for insomnia in EDs. Results of this study will inform the development and application of interventions for residual insomnia symptoms in this population.
Risk factors associated with retinopathy in young people with type 1 diabetes in Bangladesh
Authors: Zabeen Bedowra , Khaled Mohammad Zafar , Husain Lutful , Aktar Asma , Huda Kamrul , Kamal Yeasmin Afroz , Choudhury Nujhat , Azad Kishwar 
Published: December 2020

AbstractObjectivesDiabetic retinopathy (DR) is the most common microvascular complications seen in children and adolescents with type 1 diabetes. The aim of this study was to evaluate the prevalence of retinopathy and its association with other risk factors in young people with type 1 diabetes.MethodsThis study was a cross‐sectional study, which was done as part of the ongoing complication assessment in the paediatric diabetes clinic in BIRDEM (Bangladesh Institute of Research and Rehabilitation of Diabetes Endocrine and Metabolic Disorders), a tertiary care hospital. Children, adolescents and young adults with type 1 diabetes who were having diabetes duration >2 years were included in this study. Retinopathy was detected using fundal photography, and grading was done by National Screening Committee of UK by trained ophthalmologists.ResultsDiabetic retinopathy was observed in 44 (6.6%) patients. Majority (95.4%) of them had early diabetic retinopathy in the form of mild NPDR (nonproliferative diabetic retinopathy) (R1). Patients with retinopathy had higher HbA1c 9.6[8.4‐12.3] vs 9.1 [7.9‐10.8] (P = .013), longer duration of diabetes 7.6 [5.5‐10.7] vs 6.0 [4.5‐8.2] years (P = .001) and were older 21.5 [18.0‐23.0] vs 18 [16.0‐21.0] years (P = .0001) compared with those without retinopathy. On multivariate regression analysis, higher age and median HbA1c were significantly associated with DR.ConclusionsHigher HbA1c was the only modifiable risk factor for development of DR in our study population. Early detection of DR with improvement of glycaemic control may reduce the risk of progression of severe stages of the disease.
Integrated hybrid MEMS hydrogen sensor with high sensitivity and high dynamic range
Authors: Hayashi Yumi , Yamazaki Hiroaki , Masunishi Kei , Ono Daiki , Saito Tomohiro , Nakamura Naofumi , Kojima Akihiro 
Published: December 2020

AbstractThis paper discusses an integrated hybrid MEMS hydrogen sensor that detects hydrogen in the range from 5 ppm to 100 vol%. The sensor is a single chip comprising both capacitive and thermal conductivity hydrogen sensors that can be fabricated simultaneously using the same process flow. The capacitive sensor detected hydrogen at concentrations as low as 5 ppm without a heater. The thermal conductivity sensor measured high hydrogen concentrations and had a low power consumption of several tens of milliwatts. The integrated hybrid MEMS hydrogen sensor showed a high gas selectivity.
miR‐148a controls metabolic programming and survival of mature CD19‐negative plasma cells in mice
Authors: Pracht Katharina , Meinzinger Julia , Schulz Sebastian R. , Daum Patrick , Côrte‐Real Joana , Hauke Manuela , Roth Edith , Kindermann Dorothea , Mielenz Dirk , Schuh Wolfgang , Wittmann Jürgen , Jäck Hans‐Martin 
Published: December 2020

AbstractLong‐lived antibody‐secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in plasma cell differentiation, the regulatory role of miRNAs remains enigmatic. We have recently identified miR‐148a as the most abundant miRNA in primary mouse and human plasma cells. To determine whether this plasma cell signature miRNA controls the in vivo development of B cells into long‐lived plasma cells, we established mice with genomic, conditional, and inducible deletions of miR‐148a. The analysis of miR‐148a‐deficient mice revealed reduced serum Ig, decreased numbers of newly formed plasmablasts and reduced CD19‐negative, CD93‐positive long‐lived plasma cells. Transcriptome and metabolic analysis revealed an impaired glucose uptake, a reduced oxidative phosphorylation‐based energy metabolism, and an altered abundance of homing receptors CXCR3 (increase) and CXCR4 (reduction) in miR‐148a‐deficient plasma cells. These findings support the role of miR‐148a as a positive regulator of the maintenance of long‐lived plasma cells.
On the Origin of Regioselectivity in Palladium‐Catalyzed Oxidation of Glucosides
Authors: Wan Ieng Chim (Steven) , Hamlin Trevor A. , Eisink Niek N. H. M. , Marinus Nittert , de Boer Casper , Vis Christopher A. , Codée Jeroen D. C. , Witte Martin D. , Minnaard Adriaan J. , Bickelhaupt F. Matthias 
Published: December 2020

AbstractThe palladium‐catalyzed oxidation of glucopyranosides has been investigated using relativistic density functional theory (DFT) at ZORA‐BLYP−D3(BJ)/TZ2P. The complete Gibbs free energy profiles for the oxidation of secondary hydroxy groups at C2, C3, and C4 were computed for methyl β‐glucoside and methyl carba‐β‐glucoside. Both computations and oxidation experiments on carba‐glucosides demonstrate the crucial role of the ring oxygen in the C3 regioselectivity observed during the oxidation of glucosides. Analysis of the model systems for oxidized methyl β‐glucoside shows that the C3 oxidation product is intrinsically favored in the presence of the ring oxygen. Subsequent energy decomposition analysis (EDA) and Hirschfeld charge analysis reveal the role of the ring oxygen: it positively polarizes C1/C5 by inductive effects and disfavors any subsequent buildup of positive charge at neighboring carbon atoms, rendering C3 the most favored site for the β‐hydride elimination.
Separation of regioisomers and enantiomers of triacylglycerols containing branched fatty acids (iso and/or anteiso)
Authors: Palyzová Andrea , Cajthaml Tomáš , Řezanka Tomáš 
Published: December 2020

AbstractA combination of two chromatographic and one enzymatic methods was used for identification of the molecular species of triacylglycerols (TAGs) from Streptomyces avermitilis. Streptomyces avermitliswas cultured on various carbon sources and the ratio of iso‐ (i‐FAs), anteiso‐ (ai‐FAs), and straight‐chain‐ (n‐FAs) fatty acids was modified by precursor‐directed biosynthesis. Saturated TAGs were separated from other lipids (including TAGs containing unsaturated FAs) using Ag+ ion cartridges. Analysis of TAGs wereperformed by RP‐HPLC/ESI+ tandem mass spectrometry. Both the synthetically prepared sn‐TAGs and the natural mixture of TAGmolecular species of wereseparated and identified by tandem MS. The structures of synthetic TAGs werefurther confirmed by pancreatic lipase, which cleaves sn‐TAGs into sn‐2‐monoacylglycerols. The retention times (tR) of the individual regioisomers and enantiomers were found to be depend on the structure of the TAGs. If one branched acyl (iso or anteiso) is present in the TAG molecule, then the elution order is enantiomer (n/n/br), opposite enantiomer (br/n/n), regioisomer (n/br/n). In the case where two branched acyls are in the TAG molecule, the order of the elution is different, that is, br/n/br, n/br/br, br/br/n. In all cases, it was further demonstrated that tandem MS of either synthetically prepared TAGs or TAGs obtained from natural material, that is, n‐16:0/ai‐15:0/n‐16:0 and i‐16:0/n‐15:0/i‐16:0 are identical. Unfortunately, it is not possible to distinguish by ESI+ tandem MS such TAGs, which differ only in the branching of the acyls. The results of our analyses of TAGs are in good agreement with previously published data in other streptomycetes.
The gut microbiome in drug‐resistant epilepsy
Authors: Chatzikonstantinou Simela , Gioula Georgia , Kimiskidis Vasilios K. , McKenna Jack , Mavroudis Ioannis , Kazis Dimitrios 
Published: December 2020

AbstractDrug‐resistant epileptic patients make up approximately one‐third of the global epilepsy population. The pathophysiology of drug resistance has not been fully elucidated; however, current evidence suggests intestinal dysbiosis, as a possible etiopathogenic factor. Ketogenic diet, whose effect is considered to be mediated by alteration of gut microbiota synthesis, has long been administered in patients with medically refractory seizures, with positive outcomes. In this review, we present data derived from clinical studies regarding alterations of gut microbiome profile in drug‐resistant epileptic patients. We further attempt to describe the mechanisms through which the gut microbiome modification methods (including ketogenic diet, pre‐ or probiotic administration) improve drug‐resistant epilepsy, by reporting findings from preclinical and clinical studies. A comprehensive search of the published literature on the PubMed, Embase, and Web of science databases was performed. Overall, the role of gut microbiome in drug‐resistant epilepsy is an area which shows promise for the development of targeted therapeutic interventions. More research is required to confirm the results from preliminary studies, as well as safety and effectiveness of altering gut bacterial composition, through the above‐mentioned methods.
Analysis of the thermal effect of a lithium iron phosphate battery cell and module
Authors: Zhou Shuwen , Song Zhenghao , Zhao Yuemin 
Published: December 2020

AbstractBased on the theory of porous electrodes and the properties of lithium iron batteries, an electrochemical‐thermal coupling model of a single cell was established. The model was mainly used to study the temperature rise and temperature distribution characteristics in different regions of lithium iron batteries under different working conditions. In addition, a heat dissipation comparison analysis was carried out for different types of liquid cold runners, the optimal runner scheme was selected, and a structural optimization analysis was carried out. The simulation results show that the lithium iron battery discharges under the same ambient temperature and different C rates, and the battery temperature continuously increases with C. The temperature rise is mainly affected by Joule heat, and when the lithium iron battery is discharged at the same C but different ambient temperatures, the temperature rise of the lithium iron battery shows a decreasing trend with the increase in ambient temperature in a certain temperature range. The serial flow channel solution induces the best thermal behavior. Using the response surface optimization analysis, the three independent variable factors at which the temperature equilibrium R reaches the largest value under the liquid cooling module model are the rectangular flow channel length‐to‐width ratio, flow rate, and thermal conductivity.