bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Infill Well Fracturing Model and Its Microseismic Events Barrier Effect: A Case in Fuling Shale Gas Reservoir
Authors: Zhu Haiyan , Tang Xuanhe , Song Yujia , Li Kuidong , Xiao Jialin , Dusseault Maurice B. , McLennan John D. 
Published: August 2020

Summary
A microseismic (MS) events barrier (MSEB) phenomenon was detected during infill well fracturing of the Fuling shale gas reservoir. This phenomenon was evidenced by MS monitoring results, indicating that when the infill well hydraulic fracture (HF) propagated close to the parent well stimulated region, only a main straight fracture was propagating. Also, the number of seismic events diminished abruptly, suggesting some barrier or an attenuation process for the MS. To clarify the mechanisms involved in the MSEB effect, the infill well fracture propagation is investigated. An integrated workflow is proposed to analyze complex HF propagation of an infill well after the offset parent wells have experienced fracturing and production. The workflow integrates a geological model with natural fractures, a parent well fracturing geomechanical model, a coupled flow-geomechanics production model, and an infill well fracturing geomechanical model. First, a natural fracture network is embedded in the realistic geological model. Second, a geomechanical fracturing model is developed to simulate HF of parent wells. Third, a coupled flow-geomechanics model is used to analyze stress field evolution during parent well production. Fourth, complex HF propagation for the infill well is simulated. The case model is validated with parent well production data and infill well fracturing MS monitoring results. It can be concluded from the simulation results that (1) during parent well production, the pre-existing complex fracture network is a major contributor to pore-pressure decrease; (2) stress evolution is affected by the geomechanical heterogeneity; (3) near the parent well producing fractured region, the fracture complexity of the infill well stimulation decreases sharply and that matches well with the MS monitoring results; and (4) there are two primary mechanisms that are responsible for the MSEB phenomenon—natural fracture (NF) activation during parent well fracturing and stress evolution in parent well production. The Fuling shale gas reservoir infill well fracturing case study reveals the mechanism of the MSEB effect by demonstrating the impact of parent well production on infill well fracturing. To serve the fracture-hits evaluation and to maximize the stimulated reservoir volume (SRV), the MSEB effect should be taken into consideration in infill well fracturing design.
Effect of preoperative carbohydrate intake on inflammatory factors and clinical outcomes in elderly patients undergoing radical prostatectomy: a single-center, double-blind randomized controlled trial
Authors: Hu Zhen , Liu Ji , Ma Wenchao , Wang Fen 
Published: August 2020

Abstract
BACKGROUND: To investigate the advantages of Carbohydrate (CHO) in inflammatory markers, comfort and clinical outcomes in elderly patients undergoing open radical prostatectomy.METHODS: Patients of ≥65 years old with radical prostatectomy who underwent open radical prostatectomy were randomized to the CHO group, water group, and fasted group. Patients in the CHO group and water group received oral CHO, 800 ml of placebo water before surgery, and oral CHO and placebo water 400 ml 2 to 3 hours before surgery; the fasted group did not drink any liquid. The main outcomes are inflammatory markers. The secondary outcomes are cellular immunity, comfort, the index of grip strength of body mass and clinical outcomes.RESULTS: A total of 90 patients were included in current study (i.e., CHO group, n=28; water group, n=30; fasted group, n=32). The three groups matched well in age, body mass index, the grade of (American Society of Anesthesiologists) ASA, operation time, blood loss, and fluid volume. CHO reduces IL-6 of Day1 and Day7 (P = 0.009, 0.005, respectively), IL-8 (P=0.005) of Day1, Day1, Day 3, and Day 7 TNF (P = 0.001, 0.006, 0.003 respectively) compared with the fasted group ; placebo water reduced Day 1 and Day 7 TNF (P = 0.005, 0.038, respectively), Day 1of IL-8 (P = 0.045). CHO reduced Day3 of TNF (P=0.026) compared to placebo water. In the CHO group and the water group, the morning thirst scores (0.68, 1.26, respectively) and starvation (0.24, 0.47, respectively) were decreased. The first time to leave bed in the fasted group (39.21 (15-93) h) was much later than in the CHO group (28.57 (10-100) h) and the water group (28.71 (12-70) h).Conclusion: Compared with routine water ban, preoperative CHO and placebo water can reduce the levels of IL-6, IL-8 and TNF in elderly patients undergoing radical prostatectomy, which can improve the patient's preoperative comfort and shorten the patient's first time to leave bed. Compared with placebo water, CHO has no significant advantage in improving inflammatory markers and clinical outcomes.
Status of MWth Integrated Gasification Fuel Cell (IGFC) Power Generation System Demonstration in China
Authors: Wei Chang , Liu Zhien , Li Chufu , Singh Surinder , Lu Haoren , Gong Yudong , Li Pingping , Wang Hanlin , Yang Xia , Xu Ming , Mu Shujun 
Published: August 2020

Abstract
This paper provides status update of IGFC power generation system being developed at National Institute of Clean-and-Low-Carbon (NICE) at MWth scale. This system is designed to use coal as fuel to produce syngas as a first step similar to integrated gasification combined cycles (IGCC). Subsequently, the solid oxide fuel cell system is used to convert chemical energy to electricity directly through electrochemical reaction without combustion, which is different from IGCC. This system leads to a higher efficiency as compared to a traditional coal-fired power plant. The unreacted fuel in the SOFC system is transported to an oxygen-combustor to be converted to steam and CO2. Through heat recovery system, the steam is condensed and removed, and CO2 is enriched and captured for sequestration or utilization, such as co-electrolysis of CO2 and H2O using curtailed renewable energy for production of syngas. Comprehensive economic analysis for a typical IGFC system was performed and the results were compared with supercritical pulverized coal-fired (SCPC) power plant, showing the cost of electricity (COE) of IGFC could be up to 20% lower than that by SCPC with CO2 capture. The SOFC stacks selected for IGFC development were tested and qualified under both hydrogen and simulated coal syngas fuel showing good consistency and stable long term performance. Experimental results using SOFC stacks and thermodynamic analysis (using ASPEN Plus) indicate that the hydrogen to CO ratio of the syngas is preferred to be 1.68 or higher to avoid carbon deposition inside of the fuel pipe. For lower H2/CO ratio, steam to CO ratio needs to be higher. Besides, the steam needs to be mixed well with the syngas above 100oC and below the temperatures where carbon formation is thermodynamically favored. The 20kW SOFC power generation unit is being developed with design system conditions of 20 kW maximum power, current density of 0.334 A/cm2, DC efficiency of 50.41%, and fuel utilization of 80%. A 100kW-level subsystem will consist of 6 x 20kW power generation units, and the MWth IGFC system will consist of 5 x 100kW-level subsystems.
Reliable and rapid smooth extubation after Ketofol for induction of general anesthesia in Laparoscopic Drilling of polycystic ovary: A randomized controlled trial.
Authors: Mahmoud Atef Mohamed Sayed , Ragab Safaa Gaber , Botros Joseph Makram 
Published: August 2020

Abstract
Background: The impact of ketofol on the hemodynamics and the airway response during the induction of general anesthesia has been studied before. However, its effect on the smoothness of extubation has not been studied before. Thus, we aimed to assess the effect of ketofol on the smoothness of extubation and compare it with propofol for the induction of general anesthesia.Methods: This double-blind, randomized, and controlled study was conducted on 106 class I and II female patients with the “American Society of Anesthesiologists Physical Status (ASA PS),” aged 18–40 years and scheduled for laparoscopic drilling for polycystic ovary disease under general anesthesia. The patients were assigned to one of two groups of (53) patients each; group KP = ketofol and group P = propofol. Results: There was a good sedation score during suction and extubation in the ketofol group. Airway response and smoothness of extubation were better in the ketofol than in the propofol group.Conclusion: Ketofol as an induction anesthetic agent was effective in attenuating the airway response during extubation more than only propofol.Trial registration: This trial was retrospectively registered at the Clinical Trial.gov with the Identification Number: NCT04365686.
A Randomized Controlled Study on the Safety and Effectiveness of Total Knee Arthroplasty Operated At Different Times under ERASA.
Authors: Dahal Suraj , Rong Xiao , Yuan Ming-Cheng , Shakya Hirose , Tao Qi Feng , Luo Zhenyu , Zhou Zong-Ke 
Published: August 2020

Abstract
Background Total knee replacement (TKA) is the most effective surgical method for end-stage knee joint disease. However, around（75%-92%）of patients after TKA are not satisfied. In the earlier days, TKA done at different times had different outcomes. Till this date, Enhanced Recovery After TKA has upgraded to a higher level. However, its safety and effectiveness concerning time have been remained unclear. So this study, we design to compare the effectiveness and safety of TKA surgery operated at different times, under ERAS.Material and method In this study, 80 patients were randomly included for primary unilateral TKA who fulfilled the study criteria, between May 1st, 2019, and November 31th, 2019 in the Department of Orthopedics, West China Hospital of Sichuan University. All patients operated and peri-operatively managed according to standard ERAS protocol. The measuring indicators include VAS score, Range of knee motion, PSQI sleep quality score, HSS knee score, operation duration, total hospital stay, anesthesia time, first urination time, hemoglobin level, hematocrit, blood loss, blood glucose, inflammatory indicators (CRP and IL-6), radiological evaluation, gastrointestinal complications, appetite, total hospitalization costs, and satisfaction.Result Out of 80 patients, 40 were operated before 2 pm and 40 were operated after 2 pm. The VAS score for knee pain on day 1 after surgery in the group before 2 pm / after 2 pm, resting (P= 0.831); motion (P = 0.877). On discharge, resting VAS (P= 0.681); motion, (P = 0.912). At 21st days VAS Score at rest (P= 0.679), At motion (P= 0.979). Before 2 pm/after 2pm group ,Blood loss（P=0.328）,ROM at the 21st day after surgery (p = 0.476). PSQI at 21st days after surgery (P = 0.188), HSS knee score on the 21st day after surgery (P = 0.762), respectively. Conclusion Under the standard ERAS protocol, total knee replacements at different times do not affect its safety and effectiveness.Trial registration: ChiCTR, ChiCTR1900022256. Registered 2019/04/01
A novel telerehabilitation with educational program for caregivers using telelecture is a feasible procedure for fall prevention in elderly people – A pilot study
Authors: Moriichi Kentaro , Fujiya Mikihiro , Ro Takanori , Ota Tetsuo , Nishimiya Hitomi , Kodama Mariko , Yoshida Nana , Hattori Yukari , Hosokawa Tetsuya , Hishiyama Hohei , Kunimoto Masao , Hayashi Hiroki , Hirokawa Hiroyuki , Yoshida Akitoshi 
Published: August 2020

Abstract
Background: The importance of fall prevention rehabilitations has been well recognized. Recently, telerehabilitation was developed, however, there have been no reports on the use of telerehabilitation with direct support from specialists for fall prevention among the elderly. We herein reported telerehabilitation by carers educated by our novel educational program.Methods: Nine elderly people in two nursing homes were enrolled using our original criteria. Carers are educated with our educational program using telelecture system. Telerehabilitation was performed by carers following the instruction from rehabilitation specialists in Asahikawa Medical University using the telemedicine system every 2-4 weeks for three months. Carers were assessed with our original questionnaire before and after the telelecture. Berg Balance Scale (BBS), Timed Up & Go test (TUG test), Hand-held dynamometer (HHD) and Mini-Mental State Examination (MMSE) were assessed before and after telerehabilitation.Results: The average number of times to perform telerehabilitation in all institutes was 4.7. Levels of understanding of carers were significantly increased after the telelecture. No adverse event occurred during the study period. Median BBSs before and three months after telerehabilitation were 43 and 49, respectively. Those of TUG test, right and left HHD and MMSE were 17.89 and 18.53, 7.95 and 11.55, 9.85 and 13.20, and 16 and 19, respectively. All results were improved after telerehabilitation.Conclusions: Our telerehabilitation program exhibited significant effects in elderly people as well as levels of understanding rehabilitation of caregivers in the facilities for the elderly people safely.Trial registration: University Hospital Medical Information Network Clinical Trials Registry（UMIN-CTR）UMIN000041439, August 17th, 2020
Collective synthesis and dissociation of soliton molecules in parallel optical-soliton reactors
Authors: He Wenbin , Pang Meng , Yeh Dung-Han , Huang Jiapeng , Russell Philip 
Published: August 2020

Abstract
Mode-locked lasers have been widely used to explore interactions between optical solitons, including bound-soliton states that may be regarded as "photonic molecules". Conventional mode-locked lasers normally however host at most only a few solitons, which means that stochastic behaviours involving large numbers of solitons cannot easily be studied under controlled experimental conditions. Here we report the use of an optoacoustically mode-locked fibre laser to create hundreds of temporal traps or "reactors" in parallel, within each of which multiple solitons can be isolated and controlled both globally and individually using all-optical method. We achieve on-demand synthesis and dissociation of soliton molecules within these reactors, in this way unfolding a novel panorama of diverse dynamics in which the statistics of multi-soliton interactions can be studied. The results are of crucial importance in understanding dynamical soliton interactions, and may motivate potential applications for all-optical control of ultrafast light fields in optical resonators.
CT Classification of Vacuum Phenomenon Morphology and its Utility in Predicting Lumbar Vertebral Instability
Authors: Kelm Noah , Hella Jennifer , Westfall John B , Ballard Eric T , Aftab Macksood A 
Published: August 2020

Abstract
Background: Lumbar vacuum phenomenon (VP) within the intervertebral disc has been classified based on CT imaging. We compared same-patient sagittal CT images and dynamic flexion-extension x-rays to determine if there is a difference in the amount of vertebral instability present between three VP morphologies on CT.Methods: Anterior subluxation measurements on x-ray were compared with same-segment VP on CT images from the same patient when both findings were present. VP were classified as spot, island, or linear. It was determined if there was a difference in the amount of anterior subluxation between the three morphologies. Secondary analysis looked at whether there was a difference in anterior subluxation between the three groups if patients had undergone a prior lumbar fusion surgery or not. Results: There was no difference in anterior subluxation between the three groups on dynamic flexion-extension x-rays. There was also no difference between the three groups on flexion-extension x-rays when patients were separated based on if they had received or not received a previous lumbar fusion surgery. Conclusion: IVD VP morphology is not a useful indicator in determining vertebral instability pre-operatively according to CT scan. Further fine-tuning of an IVD VP CT classification is needed to help radiologists and spine surgeons know when IVD VP presence is important.
Germline mutations in hereditary breast cancer genes are associated with early age at diagnosis and family history in Guatemalan breast cancer
Authors: Ren Megan , Orozco Anali , Shao Kang , Albanez Anaseidy , Ortiz Jeremy , Cao Boyang , Wang Lusheng , Barreda Lilian , Alvarez Christian S. , Garland Lisa , Wu Dongjing , Chung Charles , Wang Jiahui , Frone Megan , Ralon Sergio , Argueta Victor , Orozco Roberto , Gharzouzi Eduardo , Dean Michael C 
Published: August 2020

Abstract
Background: Mutations in hereditary breast cancer genes play an important role in the risk for cancer, however, little is known of the type and frequency of mutations in Central American populations, including Guatemala.Methods: Two separate panels of known cancer susceptibility genes were used to sequence blood DNA from 664 unselected breast cancer cases from two large hospitals in Guatemala. Variants were annotated with ClinVar and VarSome. Data from a structured questionnaire was used to compare mutation carriers of medium and high penetrance genes.Results: A total of 73 out of 664 subjects (11%) had a variant classified as pathogenic in a gene with known high or medium penetrance for inherited breast cancer. The most frequently mutated genes were BRCA1 (37/664, 5.6%) followed by BRCA2 (15/664, 2.3%), PALB2 (5/664, 0.8%) and TP53 (5/664, 0.8%). Pathogenic variants were also detected in the moderate penetrance genes ATM, BARD1, CHEK2, and MSH6, and rare pathogenic variants detected in the low penetrance genes AXIN2, FH, MLH1, MSH2, MUTYH, NF1, and SDHB. The high ratio of BRCA1/BRCA2 mutations is due to the presence of two potential founder mutations, BRCA1 c.212 + 1G > A splice mutation (15 cases) and BRCA1 c.799delT (9 cases). Compared to all others, cases with pathogenic mutations had a significantly earlier age at diagnosis (45 vs 51 years, P < 0.001), more likely to have had diagnosis before menopause, and a higher percentage had a relative with any cancer (51% vs 37%, P = 0.038) or breast cancer (33% vs 15%, P < 0.001). Mammography usage was less frequent in lower SES women indicating this group is less likely to be screened for breast cancer (p < 0.001).Conclusions: Guatemalan women have rates of hereditary breast cancer mutations similar to other populations, and these women are more likely to have early age at diagnosis and family history. This data supports the use of genetic testing in breast cancer patients and those at high risk as part of a strategy to reduce breast cancer mortality in Guatemala.
Long Noncoding RNA LINC02747 Promotes the Proliferation of Clear Cell Renal Cell Carcinoma by Inhibiting miR-608 and Activating TFE3
Authors: Ju Xiang , Sun Yangyang , Zhang Feng , Wei Xiaohui , Wang Zhenguo , He Xiaozhou 
Published: August 2020

Abstract
Background: With the rapid development of biotechnology, long noncoding RNAs (lncRNAs) have exhibited good application prospects in the treatment of cancer, and they may become new treatment targets for cancer. This study aimed to explore lncRNAs in clear cell renal cell carcinoma (ccRCC). Methods: Differentially expressed lncRNAs in 54 pairs of ccRCC tissues and para-carcinoma tissues were analyzed in The Cancer Genome Atlas (TCGA), and the most significant lncRNAs were selected and verified in ccRCC tissues. Results: It was found that lncRNA LINC02747 was highly expressed in ccRCC, which was closely related to high TNM stage and histological grade and poor prognosis of patients. The in vivo and in vitro experiments confirmed that LINC02747 could promote the proliferation of ccRCC cells. We also found that LINC02747 regulated the proliferation of RCC cells by adsorbing miR-608. Subsequent mechanistic research showed that miR-608 is downregulated in ccRCC, and overexpression of miR-608 can inhibit the proliferation of RCC cells. Moreover, it was found that TFE3 is a direct target gene of miR-608. MiR-608 regulated the proliferation ability of RCC cells by inhibiting TFE3. In conclusion, LINC02747 upregulates the expression of TFE3 by adsorbing miR-608, ultimately promoting the proliferation ability of ccRCC cells. Conclusions: LINC02747 acts as an oncogene in ccRCC and may be developed as a molecular marker for the diagnosis and prognosis of ccRCC. The LINC02747/miR-608/TFE3 pathway may become a new therapeutic target for ccRCC.
Safety and Feasibility of Umbilical Cord Mesenchymal Stem Cells in Patients with COVID-19 Pneumonia: A Pilot Study
Authors: Feng Ying , Huang Jianying , Wu Jianyuan , Xu Yan , Chen Bo , Jiang Lijun , Xiang Hui , Peng Zhiyong , Wang Xinghuan 
Published: August 2020

Abstract
Background: We aim to explore the safety and feasibility of umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in severe and critically severe type Coronavirus disease 2019 (COVID-19) patients.Methods: In addition to normal therapy, we performed four times transplantation of UC-MSCs in 16 severe and critically severe type COVID-19 patients. We observed adverse events from enrollment to D28. We evaluated the oxygenation index, inflammatory biomarkers, chest imaging, lymphocyte subsets count et al on the 7th day (D7±1 day), the 14th day (D14±1 day) and the 28th day (D28±3 days).Results: There were no infusion-related or allergic reactions. The oxygenation index was improved after transplantation. The mortality of enrolled patients was 6.25%. The level of cytokines estimated was varied in normal range, the chest imaging was improved, the lymphocyte count and lymphocyte subsets count were recovered after transplantation.Conclusions: Intravenous transplantation of UC-MSCs was safe and feasible for treatment in patients with COVID-19 pneumonia.Trial registration: Clinical Trial, NCT04269525. Registered 7 February 2020. https://clinicaltrials.gov/ct2/show/NCT04269525
Cytomorphological Patterns of Palpable Breast Lesions Diagnosed on Fine Needle Aspiration Cytology in Jimma Hospital, Ethiopia
Authors: Abera Wondimu , Angaw Dessie Abebaw , Bezabih Mesele , Hunegnaw Melkamu Tamir 
Published: August 2020

Abstract
Background: Breast cancer is the most common cancer in women worldwide, in 2012 with nearly 1.7 million new cases were diagnosed. This represents about 12% of all new cancer cases and 25% of all cancers in women. In low and middle-income countries (LMCs), the infrastructure and resources for routine screening mammography are often unavailable.Objective: The objective of this study focused on determining the cytomorphologic patterns of palpable breast lesions in Jima University Specialized Hospital.Methods: A descriptive cross-sectional study was done on breast FNAC medical records. Analysis was done using SPSS version 20. Chi square test was applied to check the significant effect of independent variables on the dependent variables.Result: In this study 735 patients were included and the overall distribution of the lesion was benign neoplastic (51%), non-neoplastic (28%), malignancy (17%) and suspicious (4%). The most common lesions in male were non-neoplastic and in female were benign neoplastic groups. The majority of (49.3%) breast lesions were located in the left breast followed by right breast (43.9%).Conclusion: This study supports the usefulness of cytomorphological diagnostic techniques in the workout of breast lesions, confirms the predominance of benign breast lesions in the young and the occurrence of age independency in malignancy.