bluuebunny/crossref_metadata_2025_split huggingface dataset:
BingleSeq: a user-friendly R package for bulk and single-cell RNA-Seq data analysis
Authors: Dimitrov Daniel , Gu Quan 
Published: December 2020

Background
RNA sequencing is an indispensable research tool used in a broad range of transcriptome analysis studies. The most common application of RNA Sequencing is differential expression analysis and it is used to determine genetic loci with distinct expression across different conditions. An emerging field called single-cell RNA sequencing is used for transcriptome profiling at the individual cell level. The standard protocols for both of these approaches include the processing of sequencing libraries and result in the generation of count matrices. An obstacle to these analyses and the acquisition of meaningful results is that they require programing expertise. Although some effort has been directed toward the development of user-friendly RNA-Seq analysis analysis tools, few have the flexibility to explore both Bulk and single-cell RNA sequencing.

Implementation
BingleSeq was developed as an intuitive application that provides a user-friendly solution for the analysis of count matrices produced by both Bulk and Single-cell RNA-Seq experiments. This was achieved by building an interactive dashboard-like user interface which incorporates three state-of-the-art software packages for each type of the aforementioned analyses. Furthermore, BingleSeq includes additional features such as visualization techniques, extensive functional annotation analysis and rank-based consensus for differential gene analysis results. As a result, BingleSeq puts some of the best reviewed and most widely used packages and tools for RNA-Seq analyses at the fingertips of biologists with no programing experience.

Availability
BingleSeq is as an easy-to-install R package available on GitHub at https://github.com/dbdimitrov/BingleSeq/.
The effect of wearing insoles with a toe-grip bar on occupational leg swelling and lower limb muscle activity: A randomized cross-over study
Authors: Nakano Hideki , Murata Shin , Kai Yoshihiro , Abiko Teppei , Matsuo Dai , Kawaguchi Michio 
Published: December 2020

Abstract

Objective
Sitting or standing for hours decreases the blood flow in the legs and results in increased pressure on the veins, leading to the development of chronic venous disease. This study aimed to investigate the effects of insoles with a toe-grip bar on occupational leg swelling and lower limb muscle activity.

Methods
This randomized cross-over study enrolled 12 healthy men who work in a sitting or standing position. They were randomly divided into groups A (wore shoes with insoles with a toe-grip bar for 8 hours each) and B (wore shoes with regular insoles for 8 hours each). After 1 week, groups A and B wore shoes with regular insoles and shoes with insoles with a toe-grip bar, respectively, for 8 hours each. Lower leg volume was measured before and after each intervention, and lower limb muscle activity was measured at the start of each intervention.

Results
Occupational leg swelling was significantly smaller in men wearing insoles with a toe-grip bar (P &lt; .05). Moreover, the integrated electromyogram value of the tibialis anterior muscle and medial and lateral gastrocnemius muscles during the stance phase of walking, and tibialis anterior muscle during the swing phase of walking was significantly greater in men wearing insoles with a toe-grip bar (all P &lt; .05).

Conclusion
Insoles with a toe-grip bar contribute to increased lower limb muscle activity, attenuating occupational leg swelling.
Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
Authors: Ledwoń Patrycja , Errante Fosca , Papini Anna Maria , Rovero Paolo , Latajka Rafal 
Published: December 2020

AbstractCosmeceutical field, which merges cosmetics and pharmaceuticals, is nowadays a highly investigated research area, because a scientific demonstration of the claimed bioactivity of new cosmeceutical ingredients is increasingly requested. In fact, an aspect differentiating traditional cosmetics from cosmeceuticals is the identification and characterization of the active ingredients and demonstrating its efficacy in the claimed activity. An interesting group of bioactive cosmeceutical ingredients are peptides, which due to their particular properties, meets most of the requirements presented by the cosmeceutical industry when composing new formulas. In this context, beside bioactivity, two additional aspects have been recently considered, when dealing with peptides as cosmeceutical ingredients: bioavailability and stability. We describe herein novel methods applied in order to enhance peptides skin‐penetration and stability, reviewing both scientific articles and patents, issued in the cosmeceutical arena.
Role of marijuana components on the regenerative ability of stem cells
Authors: Miller Henry , De Leo Nicholas , Badach Jeremy , Lin Andrew , Williamson John , Bonawitz Steven , Ostrovsky Olga 
Published: December 2020

Stem cell therapy promotes tissue regeneration and wound healing. Efforts have been made to prime stem cells to enhance their regenerative abilities. Certain marijuana components, namely the non‐psychoactive cannabidiol (CBD) and psychoactive tetrahydrocannabinol (THC), are defined as immunomodulators.9 We test whether two sources of stem cells, primed with CBD or THC, would demonstrate improved regenerative abilities. Human adipose‐derived stem cells (ASCs) and bone marrow‐derived stem cells (BMDSCs), not obtained from the same individual, were treated with low (300 nM) or high (3 μM) concentration CBD. Porcine ASCs and BMDSCs were isolated from a single pig, and treated with either low or high concentrations of CBD or THC. Transwell migration and MTT proliferation assays were performed on the human ASCs and BMDSCs. Also, transwell migration assay was performed on the porcine ASCs and BMDSCs. Finally, a wound healing scratch assay in porcine primary fibroblasts (PFs) was performed, co‐cultured with the cannabinoid‐treated ASCs. CBD priming at low concentration induces migration by 180% (P < .01) in porcine ASCs, and by only 93% (P < .02) in porcine BMDSCs. In porcine stem cells, THC priming at low concentration induces migration by 91.6% (P < .01) in ASCs but by only 44.3% (P < .03) in BMDSCs. Compared to PFs co‐cultured with untreated ASCs, PFs co‐cultured with low CBD‐primed ASCs had 75% faster wound closure at 18 hours (P < .01). CBD and THC priming of ASCs and BMDSCs, particularly at lower doses, enhances a number of regenerative parameters, suggesting that these major marijuana components may improve stem cell‐based therapies.Significance of the studyOur study demonstrates that cannabinoids can enhance the regenerative capacity of two major sources of stem cells, adipose‐ and bone marrow‐derived, from human and porcine donors. Stem cell isolation and expansion is invasive, costly and time consuming. Stem cells with improved regenerative properties may be effective in the treatment of acute or chronic wounds. This is the first study to compare the priming potential of two sources of stem cells from the same animal, with the same genetic and epigenetic profile, as well as the first to prime with THC.
The performance of laminated glass subjected to constant heat fluxes related to building fires
Authors: Rickard Ieuan , Spearpoint Michael , Lay Simon 
Published: December 2020

SummaryA series of six exploratory experiments are presented investigating the behaviour of laminated glass when exposed to radiative heating of 25, 50 and 75 kW/m2. The laminated glass type used is typical of that which might be used in balustrades. Three experiments examined the potential for achieving flaming ignition of the inter‐layer should the glass break. At a radiant heat flux of 25 kW/m2, although the glass did not shatter, piloted ignition of the volatile gases released from the specimen edge was possible. At radiant heat fluxes of 50 and 75 kW/m2, the exposed glass layer shattered after 5 minutes 7 seconds and 2 minutes 24 seconds, respectively, and subsequently there was auto‐ignition of the volatile gases from the inter‐layer. Eventually flames were observed over the whole face of the specimen. Using an average measured mass loss and representative heat of combustion for the inter‐layer result in calculated heat release rates per unit area of 65 to 69 kW/m2. A further three experiments were carried out to examine the potential for the glass layers to separate when heated. Only one layer of glass was supported, and unsupported layer nearest the radiant heat source was observed to slip away from the other layer, exposing the inter‐layer, resulting in ignition and flaming.
Regioselective C(sp2)−C(sp3) Oxidative Bond Cleavage of 1‐(1‐Hydroxyalkyl) naphthalen‐2‐ols: First Synthesis of 1‐Azido‐halo‐naphthalene‐2(1H)‐ones
Authors: Kumar Ghosh Manoj , Roy Barnali , Sarkar Debayan 
Published: December 2020

AbstractA new one‐pot oxidative cleavage of C(sp2)−C(sp3) bond has been explored using two complementary protocols employing Phenylselenyl bromide (PhSeBr) as well as Phenyltrimethylammonium Tribromide (PTAB), with much greater efficiency and scope. The oxidative cleavage proceeds via a dearomatization step to afford potentially useful bromonaphthols along with corresponding aldehydes. In this course, we also described the first synthesis of synthetically important azido‐halo naphthaleneones.
Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus
Authors: Cheng Chi‐Fung , Lin Ying‐Ju , Lin Mei‐Chen , Liang Wen‐Miin , Chen Ching‐Chu , Chen Chien‐Hsiun , Wu Jer‐Yuarn , Lin Ting‐Hsu , Liao Chiu‐Chu , Huang Shao‐Mei , Hsieh Ai‐Ru , Tsai Fuu‐Jen 
Published: December 2020

AbstractBackgroundPatients with type 2 diabetes mellitus (T2DM) experience a two‐fold increased risk of cardiovascular diseases. Genome‐wide association studies (GWAS) have identified T2DM susceptibility genetic variants. Interestingly, the genetic variants associated with cardiovascular disease risk in T2DM Han Chinese remain to be elucidated. The present study aimed to investigate the genetic variants associated with cardiovascular disease risk in T2DM.MethodsWe performed bootstrapping, GWAS and an investigation of genetic variants associated with cardiovascular disease risk in a discovery T2DM cohort and in a replication cohort. The discovery cohort included 326 cardiovascular disease patients and 1209 noncardiovascular disease patients. The replication cohort included 68 cardiovascular disease patients and 317 noncardiovascular disease patients. The main outcome measures were genetic variants for genetic risk score (GRS) in cardiovascular disease risk in T2DM.ResultsIn total, 35 genetic variants were associated with cardiovascular disease risk. A GRS was generated by combining risk alleles from these variants weighted by their estimated effect sizes (log odds ratio [OR]). T2DM patients with weighted GRS ≥ 12.63 had an approximately 15‐fold increase in cardiovascular disease risk (odds ratio = 15.67, 95% confidence interval [CI] = 10.33–24.00) compared to patients with weighted GRS < 10.39. With the addition of weighted GRS, receiver‐operating characteristic curves showed that area under the curve with conventional risk factors was improved from 0.719 (95% CI = 0.689–0.750) to 0.888 (95% CI = 0.866–0.910).ConclusionsThese 35 genetic variants are associated with cardiovascular disease risk in T2DM, alone and cumulatively. T2DM patients with higher levels of weighted genetic risk score have higher cardiovascular disease risks.
Poly(lactide)/cellulose nanocrystal nanocomposites by high‐shear mixing
Authors: Oguz Oguzhan , Candau Nicolas , Demongeot Adrien , Citak Mehmet Kerem , Cetin Fatma Nalan , Stoclet Grégory , Michaud Véronique , Menceloglu Yusuf Z. 
Published: December 2020

AbstractThere is currently considerable interest in developing stiff, strong, tough, and heat resistant poly(lactide) (PLA) based materials with improved melt elasticity in response to the increasing demand for sustainable plastics. However, simultaneous optimization of stiffness, strength, and toughness is a challenge for any material, and commercial PLA is well‐known to be inherently brittle and temperature‐sensitive and to show poor melt elasticity. In this study, we report that high‐shear mixing with cellulose nanocrystals (CNC) leads to significant improvements in the toughness, heat resistance, and melt elasticity of PLA while further enhancing its already outstanding room temperature stiffness and strength. This is evidenced by (i) one‐fold increase in the elastic modulus (6.48 GPa), (ii) 43% increase in the tensile strength (87.1 MPa), (iii) one‐fold increase in the strain at break (∼6%), (iv) two‐fold increase in the impact strength (44.2 kJ/m2), (v) 113‐fold increase in the storage modulus at 90°C (787.8 MPa), and (vi) 103‐fold increase in the melt elasticity at 190°C and 1 rad/s (∼105 Pa) via the addition of 30 wt% CNC. It is hence possible to produce industrially viable, stiff, strong, tough, and heat resistant green materials with improved melt elasticity through high‐shear mixing.
Homeopathy in Experimental Cancer Models: A Systematic Review
Authors: dos Santos Andreza Pereira , Cardoso Thayná Neves , Waisse Silvia , Bonamin Leoni Villano 
Published: December 2020

Abstract
Background Complementary and alternative medicine, including homeopathy, is widely used to improve well-being among cancer patients and reduce adverse effects of conventional treatment. In contrast, there are few studies on the use of homeopathic medicines to treat the disease itself. Yet, evidence of possible effectiveness of homeopathic high dilutions in experimental cancer models has been published during the past 20 years.
Aim The aim of the study was to perform a systematic review of fundamental research studies on homeopathic high dilutions in cancer.
Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions.
Results Twenty-three articles met the inclusion criteria—14 in vitro, eight in vivo, and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects.
Conclusion Fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction.
Combined kinetic and Bean–Rodbell approach for describing field-induced transitions in LaFe11.6Si1.4 alloys
Authors: Moreno-Ramírez L M , Blázquez J S , Radulov I A , Skokov K P , Gutfleisch O , Franco V , Conde A 
Published: December 2020

Abstract
We propose a combination of the Kolmogorov–Johnson–Mehl–Avrami nucleation and growth theory and the Bean–Rodbell model to describe the field-induced transition in LaFe11.6Si1.4 alloys. The approach is applied to a set of bulk samples undergoing first-order transitions produced by different routes and including doping effects. The kinetic analysis of both magnetization and demagnetization processes reveals a nucleation and three-dimensional interface-controlled growth for these alloys. Introducing the kinetic process between the metastable and stable solutions of the Bean–Rodbell model, the field dependence of the magnetization/demagnetization processes, including magnetic hysteresis for different magnetic field sweeping rates, is better reproduced than with the pure model.
Influence of ionization and ion loss on radiative and gravitational instabilities of inhomogeneous plasma with dust polarization force
Authors: Jain Shweta , Sharma Prerana 
Published: December 2020

Abstract
In the present work, the radiative condensation and gravitational instabilities of inhomogeneous self-gravitating partially ionized dusty plasma have been studied with dust polarization force, ionization and recombination. The basic equations are constructed using four fluid model. The full dynamics of charged dust grains, ions and neutral species are employed considering the electrons as inertialess which have finite thermal conductivity and radiative cooling. The general dispersion relation is derived and discussed for different dusty plasma situations. It is found that the instability conditions are greatly affected due to the polarization force and recombination. Specifically, it is pointed out that the polarization force enhances the growth rate of both the radiative and gravitational instability while the recombination frequency decreases it. Both the parameters have influencing role in short wavelength regime. The e-folding times are calculated for maximum growth rates of gravitational and radiative condensation instabilities. The present work is applicable for study of interstellar molecular clouds and therefore the corresponding free fall time of molecular clouds is also presented.
Influence of anharmonic convex interparticle potential and Shapiro steps in the opposite direction of driving force
Authors: Gombar Sonja , Mali Petar , Radošević Slobodan , Tekić Jasmina , Pantić Milan , Pavkov-Hrvojević Milica 
Published: December 2020

Abstract
The response function and largest Lyapunov exponent analysis were applied to the driven overdamped Frenkel-Kontorova model with two types of anharmonic convex interparticle potentials. In both cases model reduces to a single particle model for integer values of winding number. It is shown that the mirror image of the amplitude dependence of critical depinning force and largest Lyapunov exponent observed recently in the standard Frenkel-Kontorova model (Odavić et al 2017 Commun. Nonlinear Sci. Numer. Simul.
47, 100) is not retained generally. Behaviour of systems with relatively strong interparticle force was examined and evidence for the appearance of mode-locking phenomenon in both directions of particles’ motion is presented.
COVID-19 lethality in Brazilian States using information theory quantifiers
Authors: Fernandes Leonardo H S , de Araújo Fernando H A , Silva Maria A R , Acioli-Santos Bartolomeu 
Published: December 2020

Abstract
In this paper, we presented an overview diagnosis consider the time series of daily deaths by COVID-19 in the Brazilian States using Bandt & Pompe method (BPM) to estimate the Information Theory quantifiers, more specifically the Permutation entropy (H

s
) and the Fisher information measure (F

s
). Based on the Information Theory quantifiers, we build up the Shannon-Fisher causality plane (SFCP) to promote insights into the COVID-19 temporal evolution inherent in the phenomenology associated with the number of daily deaths well as their respective locations along the SFCP. Moreover, we apply H

s
and F

s
to elaborate on the rank of the Brazilian States’ real situation, considering the number of daily death due to COVID-19 based on the complexity hierarchy. The Brazilian States that are located in the middle region of the two-dimensional plane (H

s
x F

s
), such as Amapá (AP), Roraima (RO), Acre (AC), and Tocantins (TO) are characterized by a less entropic and low disorder, which implies in high predictability of the COVID-19 lethality. While, the Brazilian States that are located in the lower-right region, such as Ceará (CE), Bahia (BA), Pernambuco (PE), and Rio de Janeiro (RJ), are characterized by high entropy and high disorder, which leads to low predictability of the COVID-19 lethality. Given this, our results provide empirical evidence that the permutation entropy is a powerful approach to predicting infectious diseases. Dynamic monitoring of permutation entropy can help policymakers to take more or less restrictive measures to combat COVID-19.
Office and industrial information systems and networks in the training of modern specialists
Authors: Eminov F I , Golitsyna I N , Eminov B F 
Published: December 2020

Abstract
Article discusses an interdisciplinary optional course “Office and industrial information systems and networks”. Course provides skills in preparing of hardware-software platform formation of a workplace. This course is developed for students whose field of study is not related to information technologies, but whose professional activities will be carried out in the modern enterprises in the context of Industry 4.0 development.
Information Technology in Development of Solid Polymer Electrolyte Fuel Cells
Authors: Fomina L V , Malakhova E A , Beznosyuk S A , Fomin A S , Raskulova T V , Lebedeva O V , Pozhidaev Yu N 
Published: December 2020

AbstractThe proton-conducting hybrid organic-inorganic composites based on tetraethoxysilane and sulfonated styrene (St) and allyl glycidyl ether (AGE) copolymers, which are characterized by high exchange capacity and specific conductivity, are formed by sol-gel synthesis. The results of a quantum-chemical calculations of the geometry of the structure of an organic-inorganic composite (for a model consisting of 78 atoms) allow us to associate an increase in the proton conductivity of hybrid membranes, compared with the initial copolymer, with the generation of crystallization water and free sulfuric acid during the formation of the composite.
Cloud technologies in energy
Authors: Konovalov Yu V , Zasukhina O A 
Published: December 2020

Abstract
A number of cloud technology features are specified in power engineering. Introduction of additional categories of cloud technologies and infrastructures taking into account the specifics of power engineering facilities was justified. The use of energy systems simulators as electrical energy systems digital twins when using cloud technologies of power systems advanced simulators, as MaaS cloud service for cloud computing deployment in IT-infrastructure of the energy community cloud is proposed.
Research on the efficiency of equipment repair works based on the random risk process
Authors: Krakovsky Y M , Hoang N A 
Published: December 2020

Abstract
In order to increase the efficiency of equipment repair work it is proposed to introduce an insurance fund that performs two functions: accumulation of payments with different frequency and cost for performing various types of repair work; payment of these works if it is necessary. The random risk process is used for the mathematical description of the insurance fund. This approach allowed us to introduce the indicators of efficiency of repair works as resource-cost risk, numerical average operating time and numerical gamma-percent resource which takes into account the fact of unrealized repair works due to lack of financial resources. A modeling program based on the event approach was created to study these indicators. Experiments based on modeling program allowed us to conclude that both risk values and reliability indicators should be preferred the variant when the frequency of payments to the insurance fund depends on the type of repair work.
On some computational problems of constructing piecewise linear approximations of functions with the Delaunay property
Authors: Plotnikov S , Popov L 
Published: December 2020

Abstract
In the article, we discuss issues related to the construction of a piecewise linear approximation of some function, information about which is limited to its values at given points from some finite set. A wide range of tasks from various fields of knowledge leads to such a formulation. A feature of the approach to the problem under consideration is the application of the Delaunay partition methodology, based on linear programming technologies. The goal is to extend this promising methodology to a more wide class of problems without requiring that the convex hull of the set is bodily.