bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Sistem Informasi Risalah Lelang di Kantor Pelayanan Kekayaan Negara dan Lelang Kota Cirebon dengan Metode Clustering Algoritma C45
Authors: Astuti Rini , Nurhidayat  
Published: February 2020

Risalah lelang merupakan berita acara, informasi proses pelelangan atau akta otentik dengan kekuatan pembuktian sempurna yang dibuat oleh pejabat lelang dari pembelian suatu barang melalui proses lelang. Risalah lelang juga dapat digunakan dalam membantu mencari informasi pemenang lelang, ataupun banyaknya barang yang tidak terjual, barang yang berhasil terjual maupun jenis barang yang paling banyak terjual dalam proses lelang. Sistem Informasi Risalah Lelang merupakan suatu kumpulan dari komponen-komponen dalam perusahaan atau organisasi yang berhubungan dengan proses penciptaan dan pengaliran informasi tentang risalah lelang atau berita acara proses lelang.
Pengembangan sistem informasi risalah lelang berbasis web menerapkan pengelompokan dengan menggunakan Algoritma C45 dengan metode clustering, clustering merupakan proses yang digunakan untuk mengelompokkan objek sesuai informasi yang diperoleh dari data yang menyamakan anggota dalam kelasnya. Pendekatan proses pengembangan yang digunakan adalah pendekatan berorientasi objek dengan tool UML dengan model proses prototyping.
Melalui sistem ini, dapat memudahkan proses pencarian informasi risalah lelang pada Kantor Kekayaan Negara dan Lelang kota Cirebon. Serta dapat memudahkan dalam penyajian informasi berupa data lelang terbanyak dan sebagainya, juga mampu meningkatkan kualitas kerja pegawai dalam hal pemanfaatan waktu dan meningkatkan pelayanan.
Les testaments, l’usure, les statuts
Authors: Duval Sylvie 
Published: February 2020

À la fin du xiiie siècle, le deuxième concile de Lyon (1274) prend acte du lien existant entre testaments et restitution des usures post mortem : avec la constitution Quamquam, les pères conciliaires réglementent cette pratique, et demandent en outre aux testateurs une caution garantissant la restitution. Les constitutions synodales toscanes du début du xive siècle intègrent cette nouvelle norme, en instaurant des règles très précises à ce sujet, destinées aux curés, aux testateurs et aux notaires. Le thème de l’usure, toutefois, est aussi amplement abordé dans les statuts communaux. Se crée donc ainsi, à propos de l’usure et de sa restitution, une concurrence entre différents types de législations, amplement documentée dans le cas de Pise. À travers l’examen des constitutions de l’archevêque Simone Saltarelli (1324), des statuts communaux contemporains et de documents nous permettant de comprendre comment ces différentes législations étaient effectivement appliquées (testaments, procès), la présente étude montre que cette concurrence était à l’origine d’une certaine inquiétude chez les citoyens « pécheurs » (comment concilier restitution des usures et transmission des biens ?), mais qu’elle pouvait aussi, du moins pour ceux qui étaient assistés par des juristes compétents, créer des espaces de liberté.
Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model
Authors: Lewis Brandon W. , Vo Thao , Choudhary Ishita , Kidder Allison , Bathula Chandra , Ehre Camille , Wakamatsu Nobuko , Patial Sonika , Saini Yogesh 
Published: February 2020

Abstract
Cystic fibrosis is characterized by dehydration of the airway surface liquid layer with persistent mucus obstruction. Th2 immune responses are often manifested as increased mucous cell density (mucous cell metaplasia) associated with mucus obstruction. IL-33 is a known inducer of Th2 immune responses, but its roles in mucus obstruction and related phenotypes in a cystic fibrosis–like lung disease model (i.e., Scnn1b-Tg–positive [Tg+]) mouse, remain unclear. Accordingly, IL-33 knockout (IL-33KO) Tg+ mice were examined and compared with IL-33 heterozygous (IL-33HET) Tg+ mice. As compared with IL-33HET/Tg+ mice, IL-33KO/Tg+ mice had complete absence of bronchoalveolar lavage fluid eosinophilia, accompanied with significant reduction in bronchoalveolar lavage fluid concentration of IL-5, a cytokine associated with eosinophil differentiation and recruitment, and IL-4, a major Th2 cytokine. As compared with IL-33HET/Tg+ mice, IL-33KO/Tg+ mice had significantly reduced levels of Th2-associated gene signatures (Slc26a4, Clca1, Retnla, and Chi3l4), along with complete loss of intracellular mucopolysaccharide staining in the airway epithelium. As compared with IL-33HET/Tg+ mice, although the IL-33KO/Tg+ mice had significantly reduced levels of MUC5AC protein expression, they showed no reduction in the degree of mucus obstruction, MUC5B protein expression, bacterial burden, and neonatal mortality. Interestingly, the histological features, including subepithelial airway inflammation and alveolar space enlargement, were somewhat exaggerated in IL-33KO/Tg+ mice compared with IL-33HET/Tg+ mice. Taken together, our data indicate that although IL-33 modulates Th2 inflammatory responses and MUC5AC protein production, mucus obstruction is not dependent on IL-33.
Thematic analysis of the social aspects of nordic walking: the instructors’ perspective
Authors: Zurawik Marta Anna 
Published: February 2020

PurposeThe health benefits of Nordic walking have been widely examined in previous studies. However, the social benefits of the activity are still unknown. The aim of this study is to explore various social aspects of Nordic walking from the instructors’ perspective related to the activity participation.MethodsOverall, 14 Nordic walking instructors contacted electronically via the International Nordic Walking Federation instructor database completed open-ended questionnaires. The open-ended questionnaire consisted of 17 questions, grouped in sections (socio-demographic characteristics, career background, motives for becoming a Nordic walking instructor, characteristics of Nordic walking groups, means of promoting Nordic walking in local communities, group dynamics, and perceived barriers to participation). The data were content-analysed by using qualitative-data-management software MAXQDA 10.ResultsParticipation in Nordic walking focused on building and maintaining strong social relationships between practitioners and instructors, which offered social and emotional support within the groups. The study identified environmental and psychological barriers to Nordic walking. Environmental barriers were associated with the weather and seasonal conditions, and the diversity of built and natural environments. Psychological barriers to Nordic walking referred to a negative image of walking with poles.ConclusionsNordic walking was suitable for people who searched for an opportunity to exercise with the intention for socialising and improving health.
Functionality and quality of life in patients with amyotrophic lateral sclerosis: a cross-sectional study
Authors: Oliveira Priscila Gomes de Jesus , Aramaki Roberta da Silva , Silva Alex Eduardo da , Luvizutto Gustavo José , Souza Luciane Aparecida Pascucci Sande de 
Published: February 2020

PurposeTo identify factors constraining functionality and life quality in amyotrophic lateral sclerosis (ALS).MethodsCross-sectional study in 6 ALS patients aged 51.16 ± 8.70 years, with disease duration of 3.16 ± 2.63 years. Amyotrophic Lateral Sclerosis Severity Scale (ALSSS) and Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R/BR) served to evaluate functionality; Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40) analysed life quality. Descriptive statistics was applied to clinical characteristics. The correlation of clinical profile and disease duration with the degree of functionality and life quality was verified by Spearman’s correlation, with values considered significant if <i>p</i> < 0.05
and <i>r</i> > 0.8.ResultsThere was a positive correlation of age with ALSFRS (<i>r</i> = 0.852), disease duration with ALSAQ-40/physical mobility (<i>r</i> = 0.805), ALSFRS-R with ALSSS (<i>r</i> = 0.972), physical mobility with food (<i>r</i> = 0.881), and communication with emotional status (<i>r</i> = 0.947). Negative correlations were observed of age with mobility (<i>r</i> = –0.805) and emotional status (<i>r</i> = –0.876), disease duration with ALSFRS-R (<i>r</i> = –0.858) and ALSSS (<i>r</i> = –0.930), ALSFRS-R with physical mobility (<i>r</i> = –0.978) and food (<i>r</i> = –0.855), ALSSS with physical mobility (<i>r</i> = –0.910) and daily life activity (<i>r</i> = –0.874).ConclusionsLonger disease was associated with lower functionality and poor life quality. Better functionality indicated lower severity and higher life quality in physical mobility and food. Higher severity was bound with poor life quality in physical mobility and daily life activity. We also observed correlations of physical mobility with food, and communication
with emotional status.
Using flow cytometry and light-induced fluorescence to characterize the variability and characteristics of bioaerosols in springtime in Metro Atlanta, Georgia
Authors: Negron Arnaldo , DeLeon-Rodriguez Natasha , Waters Samantha M. , Ziemba Luke D. , Anderson Bruce , Bergin Michael , Konstantinidis Konstantinos T. , Nenes Athanasios 
Published: February 2020

Abstract. The abundance and speciation of primary biological aerosol particles (PBAP)
is important for understanding their impacts on human health, cloud
formation, and ecosystems. Towards this, we have developed a protocol for
quantifying PBAP collected from large volumes of air with a portable
wet-walled cyclone bioaerosol sampler. A flow cytometry (FCM) protocol was
then developed to quantify and characterize the PBAP populations from the
sampler, which were confirmed against epifluorescence microscopy. The
sampling system and FCM analysis were used to study PBAP in Atlanta, GA, over
a 2-month period and showed clearly defined populations of nucleic-acid-containing particles: low nucleic acid-content particles above threshold
(LNA-AT) and high nucleic acid-content particles (HNA) likely containing
wet-ejected fungal spores and pollen. We find that the daily-average springtime
PBAP concentration (1 to 5 µm diameter) ranged between 1.4×104 and 1.1×105 m−3. The LNA-AT population
dominated PBAP during dry days (72±18 %); HNA dominated the PBAP
during humid days and following rain events, where HNA comprised up to
92 % of the PBAP number. Concurrent measurements with a Wideband
Integrated Bioaerosol Sensor (WIBS-4A) showed that fluorescent
biological aerosol particles (FBAP) and total FCM counts
are similar; HNA (from FCM) moderately correlated with ABC-type FBAP
concentrations throughout the sampling period (and for the same particle
size range, 1–5 µm diameter). However, the FCM LNA-AT population,
possibly containing bacterial cells, did not correlate with any FBAP type.
The lack of correlation of any WIBS FBAP type with the LNA-AT suggests
that airborne bacterial cells may be more difficult to unambiguously detect with
autofluorescence than currently thought. Identification of bacterial cells
even in the FCM (LNA-AT population) is challenging, given that the
fluorescence level of stained cells at times may be comparable to that seen
from abiotic particles. HNA and ABC displayed the highest concentration on a
humid and warm day after a rain event (14 April 2015), suggesting that both
populations correspond to wet-ejected fungal spores. Overall, information
from both instruments combined reveals a highly dynamic airborne bioaerosol
community over Atlanta, with a considerable presence of fungal spores during
humid days and an LNA-AT population dominating the bioaerosol community during dry
days.
Brief communication: A double-Gaussian wake model
Authors: Schreiber Johannes , Balbaa Amr , Bottasso Carlo L. 
Published: February 2020

Abstract. In this paper, an analytical wake model with a double-Gaussian velocity
distribution is presented, improving on a similar formulation by Keane et al. (2016). The choice of a double-Gaussian shape function is motivated by the
behavior of the near-wake region that is observed in numerical simulations and
experimental measurements. The method is based on the conservation of
momentum principle, while stream-tube theory is used to determine the wake
expansion at the tube outlet. The model is calibrated and validated using
large eddy simulations replicating scaled wind turbine experiments. Results
show that the tuned double-Gaussian model is superior to a single-Gaussian
formulation in the near-wake region.
Desafios relacionados à avaliação do estresse oxidativo no processo de envelhecer
Authors: Chies Agnaldo Bruno , Munhoz Guilherme Costa , De Oliveira Priscilla Bianca 
Published: February 2020

O estresse oxidativo é definido como uma condição fisiopatológica em que produção de espécies reativas excede a capacidade das defesas antioxidantes do organismo em removê-las. Avaliar o grau de estresse oxidativo é essencial para a compreensão de diversos processos fisiologicos que mantêm a homestasia nasdiversas fases do ciclo da vida. Para isso, diversas técnicas simples e baratas podem ser empregadas. O presente trabalho propõe-se a apresentar algumas técnicas de estudo do estudo do estresse oxidativo, fazendo uma reflexão acerca de suas potencialidades e limitações. Pode se dizer que a credibilidade do estudo eleva--se pelo cuidado na padronização das técnicas, rigor do delineamento experimental e pela confirmação dos resultados através de diferentes técnicas, que avaliam diferentes processos que determinam o balanço redox.
Three new Cryptochetum Rondani, 1875 (Diptera: Cryptochetidae) from Yunnan Province, China and an identification key to Chinese species
Authors: Xi Yuqiang , Yin Xinming 
Published: February 2020

Three species of the genus Cryptochetum Rondani, 1875 from China are described and figured as new to science: C. euthyiproboscise sp. nov., C. glochidiatusum sp. nov., and C. longilingum sp. nov. An identification key to the known species of Cryptochetum from China is presented. The type specimens of the new species are deposited in the Henan Agricultural University.
The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway
Authors: Elder David E. , Bastian Boris C. , Cree Ian A. , Massi Daniela , Scolyer Richard A. 
Published: February 2020

Context.—There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.Objective.—To discuss development of the 9 distinct types of melanoma and distinguishing them by their epidemiology, clinical and histologic morphology, and genomic characteristics. Each melanoma subtype is placed at the end of an evolutionary pathway that is rooted in its respective precursor, wherever appropriate and feasible, based on currently known data. Each precursor has a variable risk of progression culminating in its fully evolved, invasive melanoma.Data Sources.—This review is based on the “Melanocytic Tumours” section of the 4th edition of the WHO Classification of Skin Tumours, published in 2018.Conclusions.—Melanomas were divided into those etiologically related to sun exposure and those that are not, as determined by their mutational signatures, anatomic site, and epidemiology. Melanomas on the sun-exposed skin were further divided by the histopathologic degree of cumulative solar damage (CSD) of the surrounding skin, into low and high CSD, on the basis of degree of associated solar elastosis. Low-CSD melanomas include superficial spreading melanomas and high-CSD melanomas incorporate lentigo maligna and desmoplastic melanomas. The “nonsolar” category includes acral melanomas, some melanomas in congenital nevi, melanomas in blue nevi, Spitz melanomas, mucosal melanomas, and uveal melanomas. The general term melanocytoma is proposed to encompass “intermediate” tumors that have an increased (though still low) probability of disease progression to melanoma.
Democracia, transparência e accountability: modelagem de avaliação de portais de transparência
Authors: Machado Júnior Eliseu Vieira , Carvalho Claudia Regina Rosal 
Published: February 2020

A necessidade da transparência e elementos de accountability dos atos de governo vêm sendo altamente requerida pela sociedade que tem clamado por um país mais transparente, mais digno, mais democrático. Principalmente a partir da vigência da Constituição Federal de 1988, a administração pública vem adotando normativas e práticas de transparência para incentivar o controle social. A partir de revisão literária em trabalhos científicos, legislação e manifestações da sociedade civil, buscou-se nesta pesquisa criar uma modelagem de avaliação que incorporasse elementos de democracia, accountability e transparência. A modelagem foi denominada TLS por trazer a síntese de aspectos teóricos, legais e sociais em sua avaliação. A partir de oito modelos originais, chegou-se a um checklist com 109 itens avaliativos. A modelagem foi aplicada no portal transparência do Estado de Goiás e avaliou-se numa escala de cinco níveis, que o site possui o terceiro nível de transparência dentre os parametrizados. Após a compilação dos resultados da pesquisa, concluiu-se que, apesar de o portal apresentar características funcionais de boa qualidade, ampla gama de informações e serviços, ele não contribui com plenitude para o exercício do controle social pelo cidadão, pois não há espaços de interação, falta incentivo à participação social e algumas informações não são prestadas de forma tempestiva o que dificulta o diálogo entre Poder Público e sociedade.
Incorporation and Impact of a Clinical Pharmacist in a Hospital-Based Neurology Clinic Treating Patients with Multiple Sclerosis
Authors: May Alexandria , Morgan Olivia , Quairoli Kristi 
Published: February 2020

Abstract

Background:
Clinical pharmacists are uniquely positioned to assist with the complexities of medication management for patients with multiple sclerosis (MS). The objective was to describe clinical pharmacy services provided, as well as provider satisfaction with and perceived impact of incorporating a clinical pharmacist in MS patient care.

Methods:
The study consisted of a retrospective medical record review and a provider survey conducted in an outpatient neurology clinic at an academic medical center. Between April 2017 and June 2018, electronic medical records of patients with documented interventions by a pharmacist were reviewed to describe clinical pharmacy services provided to patients with MS. A voluntary, anonymous survey was distributed to neurology providers to evaluate provider satisfaction with and perceived impact of clinical pharmacist involvement in MS patient care.

Results:
There were 64 patients identified with 378 documented interventions made by clinical pharmacists. Pharmacist interventions were mostly related to facilitating medication access (n = 208), pretreatment screening (n = 57), patient counseling (n = 51), and providing drug information (n = 43). All nine providers surveyed indicated that facilitating medication access, counseling patients, and managing drug interactions were moderately or very important clinical pharmacy services. Furthermore, all providers surveyed strongly agreed that pharmacist involvement decreased time to therapy initiation and provider time spent on medication management.

Conclusions:
Clinical pharmacists play an integral role in MS patient care, particularly with facilitating medication access. Prospective studies are needed to further evaluate the contribution of clinical pharmacists in MS patient care.
Modelling the prognostic effect of glucose and lipid profiles on stroke recurrence in Malaysia: an event-history analysis
Authors: Chen Xin Wee , Nazri Shafei Mohd , Abdul Aziz Zariah , Nazifah Sidek Norsima , Imran Musa Kamarul 
Published: February 2020

Background
Diabetes and dyslipidemia are significantly associated with stroke recurrence, yet the evidence for this relationship is conflicting. Consequently, the parameters in the glucose and lipid profiles may inform us regarding their relationship with stroke recurrence, thus enhancing the physicians’ clinical decision-making.

Aim
This study sought to investigate whether glucose and lipid profiles could prognosticate stroke recurrence in Malaysia.

Methods
We conducted a retrospective hospital-based study where we analyzed the first-ever stroke cases regarding about which the Malaysia National Stroke Registry was informed between 2009 and 2017, that fulfilled this study’s criteria, and that were followed for stroke recurrence. Using the Cox proportional hazard regression analysis, we estimated the adjusted hazard ratios (HRs), which reflected the prognostic effect of the primary variables (i.e., glucose and lipid profiles on the first-stroke admission) on stroke recurrence.

Results
Among the 8,576 first-ever stroke patients, 394 (4.6%) experienced a subsequent first stroke recurrence event. The prognostic effect measured by univariable Cox regression showed that, when unadjusted, ten variables have prognostic value with regards to stroke recurrence. A multivariable regression analysis revealed that glucose was not a significant prognostic factor (adjusted HR 1.28; 95% CI [1.00–1.65]), while triglyceride level was the only parameter in the lipid profile found to have an independent prognostication concerning stroke recurrence (adjusted HR: 1.28 to 1.36).

Conclusions
Triglyceride could independently prognosticate stroke recurrence, which suggests the role of physicians in intervening hypertriglyceridemia. In line with previous recommendations, we call for further investigations in first-ever stroke patients with impaired glucose and lipid profiles and suggest a need for interventions in these patients.
When does reproductive interference occur? Predictions and data
Authors: Kyogoku Daisuke 
Published: February 2020

AbstractReproductive interference is interspecific sexual interactions that are costly to at least one species involved. Although many studies have reported a substantial fitness cost associated with reproductive interference, suggesting its ecological significance, others have not observed reproductive interference in study species. Reproductive interference that incurs a large fitness cost is more likely to occur during secondary contacts than between long‐coexisting species. I first explain the rationale underlying this prediction using existing literature. Next, I present a conceptual framework to classify pairs of interacting species into one of four states, defined by the ecological and evolutionary stabilities of the species pairs. I discuss how the stability states of species pairs are likely to change over time, along with changes in the demographic and evolutionary role of reproductive interference. I then perform literature survey to test the prediction that reproductive interference should be more prevalent in secondary contact. Finally, I discuss the implications of the proposed conceptual framework and literature survey result.