bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of non-malignant diseases with thrombocytosis: a prospective cohort study in general practice
Authors: Clarke Cansu , Hamilton Willie , Price Sarah , Bailey Sarah ER 
Published: November 2020

BackgroundThrombocytosis is an excess of platelets, which is diagnosed as a platelet count >400 × 109/l. An association of thrombocytosis with undiagnosed cancer has recently been established, but the association with non-malignant disease has not been studied in primary care.AimTo examine, in English primary care, the 1-year incidence of non-malignant diseases in patients with new thrombocytosis and the incidence of pre-existing non-malignant diseases in patients who develop new thrombocytosis.Design and settingProspective cohort study using English Clinical Practice Research Datalink data from 2000 to 2013.MethodNewly incident and pre-existing rates of non-malignant diseases associated with thrombocytosis were compared between patients with thrombocytosis and age- and sex-matched patients with a normal platelet count. Fifteen candidate non-malignant diseases were identified from literature searches.ResultsIn the thrombocytosis cohort of 39 850 patients, 4579 (11.5%) were newly diagnosed with any one of the candidate diseases, compared with 443 out of 9684 patients (4.6%) in the normal platelet count cohort (relative risk [RR] 2.5, 95% confidence intervals [CI] = 2.3 to 2.8); iron-deficiency anaemia was the most common new diagnosis (4.5% of patients with thrombocytosis, RR 4.9, 95% CI = 4.0 to 6.1). A total of 22 612 (57.0%) patients with thrombocytosis had a pre-existing non-malignant diagnosis compared with 4846 patients (50%) in the normal platelet count cohort (odds ratio 1.3, 95% CI = 1.2 to 1.4). There was no statistically significant difference in cancer diagnoses between patients with and without pre-existing disease in the thrombocytosis cohort.ConclusionThrombocytosis is associated with several non-malignant diseases. Clinicians can use these findings as part of their holistic diagnostic approach to help guide further investigations and management of patients with thrombocytosis.
Look who’s talking now: Cancer in primary care on Twitter. An observational study
Authors: Milley Kristi M , Chima Sophie A , Cummings Kara-Lynne , Emery Jon D 
Published: November 2020

BackgroundTwitter is a microblogging platform that helps share information. It is a dynamic tool that has been embraced by many user types including consumers and healthcare professionals (HCPs). Currently, there are no data on how cancer in primary care features on Twitter.AimTo explore the type of users and information shared about cancer in primary care on Twitter.Design & settingA descriptive exploratory study took place of publicly available Twitter data.MethodTweets were searched between July 2015 and June 2017 for ‘GP’, ‘general practice’, ‘primary care’, or ‘general practitioner’ in conjunction with ‘cancer’. A 20% random sample was coded for geographic location, user type, type of tweet, and theme. Tweet sentiment was analysed using R package sentimentr. Content that gained traction was compared by combining original tweets, retweets, favourites, and duration.ResultsThere were a total of 3413 tweets from 1611 users in 44 countries. Consumers were the largest user group followed by health organisations, healthcare professionals, and the media. The most common theme across user types was diagnostic delay. Other themes that emerged included cancer screening, symptom awareness, and early diagnosis. Consumers published more negative tweets, particularly in relation to diagnostic delay. Health organisations focused on symptom awareness and screening. Over half of media tweets were stories that featured delayed diagnosis or screening.ConclusionA broad range of users engage with Twitter to share information about cancer in primary care. Content is different between user groups, but diagnostic delay and symptom awareness are common themes. Healthcare and professional organisations may need to consider approaches to counter negative messages about diagnostic delay.
GP decisions to participate in emergencies: a randomised vignette study
Authors: Hjortdahl Magnus , Gyrd-Hansen Dorte , Halvorsen Peder A 
Published: November 2020

BackgroundGPs use their judgement on whether to participate in emergencies; however, little is known about how GPs make their decisions on emergency participation.AimTo test whether GPs' participation in emergencies is associated with cause of symptoms, distance to the patient, other patients waiting, and out-of-hours (OOH) clinic characteristics.Design & settingAn online survey was sent to all GPs in Norway (n = 4701).MethodGPs were randomised to vignettes describing a patient with acute shortness of breath and asked whether they would participate in a callout. The vignettes varied with respect to cause of symptoms (trauma versus illness), distance to the patient (15 minutes versus 45 minutes), and other patients waiting at the OOH clinic (crowding versus no crowding). The survey included questions about OOH clinic characteristics.ResultsOf the 1013 GPs (22%) who responded, 76% reported that they would participate. The proportion was higher in trauma (83% versus 69%, χ2 24.8, P<0.001), short distances (80% versus 71%, χ2 9.5, P=0.002), and no crowding (81% versus 70% χ2 14.6, P<0.001). Participation was associated with availability of a manned-response vehicle (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] = 1.25 to 3.41), and team training at the OOH clinic once a year (OR = 1.78, 95% CI = 1.12 to 2.82) or more than once a year (OR = 3.78, 95% CI = 1.64 to 8.68).ConclusionGPs were less likely to participate in emergencies when the incident was not owing to trauma, was far away, and when other patients were waiting. A manned-response vehicle and regular team training were associated with increased participation.
ENDOGENOUS GROWTH MODEL WITH HUMAN CAPITAL ON THE CIRCLE
Authors: Королев А.В. 
Published: November 2020

В статье рассматривается модель эндогенного роста с человеческим капи-талом на простой пространственной структуре (окружности). Особое вни-мание уделено специальному случаю - комбинации параметров, при кото-рой удаётся получить решение задачи центрального планировщика на окружности в явном виде, что другим авторам не удавалось.
In this article the endogenous growth model with human capital on the simple spatial structure (the circle) is considered. We pay main attention to a special case of a combination of parameters for which we were able to solve the central plan-ner problem on the circle in an explicit form, which other authors did not suc-ceed to do.
THE EFFECT OF STATEGIC MANAGEMENT ON MANAGERIAL PERFORMANCE WITH STRATEGIC IMPLEMENTATION AS A MODERATING VARIABLES (EMPIRICAL STUDY OF THE PULO GADUNG INDUSTRIAL AREA, JAKARTA)
Authors: Apollo Apollo 
Published: November 2020

This study aims to obtain empirical evidence of the influence of external factors, internal factors, strategic planning, strategic implementation on managerial performance. The research unit is 66 respondents on Banking in Jakarta. Methods of analysis tools using path analysis or a combination of correlation and regression to determine the effect of partially or simultaneously. This study was conducted with two models: 1st Model: Influence of External Factors (X1), Internal Factors (X2), Strategic Planning (X3), and the Strategic Implementation (M) on Managerial Performance (Y) either partially or simultaneously among others: partially: the influence of external factors (X1) on managerial performance (Y) of 75.8 % significantly by 0,011, or 11 %, the effect of internal factors (X2) on managerial performance (Y) equal to 61.8 % of non significant ; influence planning strategic (X3) on managerial performance (Y) equal to 74.2 % of non significant ; influence the strategic implementation (M) on managerial performance (Y) by 5 % non- significant . Simultaneously: the influence of external factors (X1), internal factors (X2), strategic planning (X3), and strategic implementation (M) on managerial performance (Y) by a significant 60.2 %. 2nd Model: Influence of External Factors (X1), Internal Factors (X2), and Strategic Planning (X3), the Managerial Performance (Y) with Strategic Implementation (M) as a moderating variable either partially or simultaneously among others: The results of this study have consistency with the entire framework, literature review, and previous studies . The suggestion for the study: (a) for the development of advanced management accounting research is needed outside the model, such other factors which managerial performance (b) to formulate clear policies and management needs to be more concrete criteria above considerations external factors, internal factors, strategic planning, and implementing strategies to improve the performance of managerial
Binding Energies of Interstellar Molecules on Crystalline and Amorphous Models of Water Ice by Ab Initio Calculations
Authors: Ferrero Stefano , Zamirri Lorenzo , Ceccarelli Cecilia , Witzel Arezu , Rimola Albert , Ugliengo Piero 
Published: November 2020

Abstract
In the denser and colder (≤20 K) regions of the interstellar medium (ISM), near-infrared observations have revealed the presence of submicron-sized dust grains covered by several layers of H2O-dominated ices and “dirtied” by the presence of other volatile species. Whether a molecule is in the gas or solid-phase depends on its binding energy (BE) on ice surfaces. Thus, BEs are crucial parameters for the astrochemical models that aim to reproduce the observed evolution of the ISM chemistry. In general, BEs can be inferred either from experimental techniques or by theoretical computations. In this work, we present a reliable computational methodology to evaluate the BEs of a large set (21) of astrochemical relevant species. We considered different periodic surface models of both crystalline and amorphous nature to mimic the interstellar water ice mantles. Both models ensure that hydrogen bond cooperativity is fully taken into account at variance with the small ice cluster models. Density functional theory adopting both B3LYP-D3 and M06-2X functionals was used to predict the species/ice structure and their BEs. As expected from the complexity of the ice surfaces, we found that each molecule can experience multiple BE values, which depend on its structure and position at the ice surface. A comparison of our computed data with literature data shows agreement in some cases and (large) differences in others. We discuss some astrophysical implications that show the importance of calculating BEs using more realistic interstellar ice surfaces to have reliable values for inclusion in the astrochemical models.
Finding Signs of Life on Transiting Earthlike Planets: High-resolution Transmission Spectra of Earth through Time around FGKM Host Stars
Authors: Kaltenegger Lisa , Lin Zifan , Rugheimer Sarah 
Published: November 2020

Abstract
The search for life in the universe mainly uses modern Earth as a template. However, we know that Earth’s atmospheric composition changed significantly through its geological evolution. Recent discoveries show that transiting, potentially Earthlike, exoplanets orbit a wide range of host stars, which strongly influence their atmospheric composition and remotely detectable spectra. Thus, a database for transiting terrestrial exoplanets around different host stars at different geological times is a crucial missing ingredient to support observational searches for signs of life in exoplanet atmospheres. Here, we present the first high-resolution transmission spectra database for Earthlike planets, orbiting a wide range of host stars, throughout four representative stages of Earth’s history. These correspond to a prebiotic high-CO2 world—about 3.9 billion years ago in Earth’s history—and three epochs through the increase in oxygen from 0.2% to modern atmospheric levels of 21%. We demonstrate that the spectral biosignature pairs O2+CH4 and O3+CH4 in the atmosphere of a transiting Earthlike planet would show a remote observer that a biosphere exists for oxygen concentrations of about 1% of modern Earth’s—corresponding to about 1–2 billion years ago in Earth’s history—for all host stars. The full model and high-resolution transmission spectra database, covering 0.4–20 μm, for transiting exoplanets—from young prebiotic worlds to modern Earth analogs orbiting a wide range of host stars—is available online. It is a tool to plan and optimize our observation strategy, train retrieval methods, and interpret upcoming observations with ground- and space-based telescopes.
The Impact of Outflows Driven by Active Galactic Nuclei on Metals in and around Galaxies
Authors: Choi Ena , Brennan Ryan , Somerville Rachel S. , Ostriker Jeremiah P. , Hirschmann Michaela , Naab Thorsten 
Published: November 2020

Abstract
Metals in the hot gaseous halos of galaxies encode the history of star formation as well as the feedback processes that eject metals from the galaxies. X-ray observations suggest that massive galaxies have extended distributions of metals in their gas halos. We present predictions for the metal properties of massive galaxies and their gaseous halos from recent high-resolution zoom-in simulations that include mechanical and radiation-driven feedback from active galactic nuclei (AGN). In these simulations, AGN launch high-velocity outflows, mimicking observed broad absorption line winds. By comparing two sets of simulations with and without AGN feedback, we show that our prescription for AGN feedback is capable of driving winds and enriching halo gas “inside-out” by spreading centrally enriched metals to the outskirts of galaxies, into the halo and beyond. The metal (iron) profiles of halos simulated with AGN feedback have a flatter slope than those without AGN feedback, consistent with recent X-ray observations. The predicted gas iron abundance of group scale galaxies simulated with AGN feedback is Z
Fe = 0.23 Z
Fe,⊙ at 0.5r
500, which is 2.5 times higher than that in simulations without AGN feedback. In these simulations, AGN winds are also important for the metal enrichment of the intergalactic medium, as the vast majority of metals ejected from the galaxy by AGN-driven winds end up beyond the halo virial radius.
Customized Smart Glasses for Needy Blind People
Authors: R Abirami , S Haarini , P Hari Prasanth 
Published: November 2020

Visually challenged individuals are one of the most concerned people in the society in terms of independence and confidence. There is a class of needy blind people who are not able to afford the technical devices designed for them. A personalized smart device designed using deep learning technologies will be of greater help to them. A brief discussion was made with them to make the design of this device more user specific. Requirements gathered from this meeting are processed using deep learning methods and are composed into a smart glass using Raspberry pi. This glass is customized for every user such that it detects presence of known people around them and also does priority specific object detection. The compact, stand alone and economically efficient design of this product is welcomed by the needy blind people with great enthusiasm. This product will thus effectively increase their morale and ability to roam outdoors notably.
Aspetti clinici, bioetici e medico-legali della gestione delle ambiguità genitali
Authors: Di Pietro Maria Luisa 
Published: November 2020

L’ambiguità dei genitali esterni può rendere difficile l’assegnazione di sesso alla nascita e porre l’equipe medica numerosi interrogativi circa la gestione del caso. Anche oggi che la diagnosi di sesso viene fatta in epoca prenatale per via ecografica, le decisioni sulla condotta da tenere vengono prese dopo la nascita.
In questo articolo, vengono analizzati gli aspetti clinici, bioetici e medico-legali dell’assegnazione di sesso. Dopo un richiamo sui fattori biologici e culturali responsabili della differenziazione sessuale, vengono illustrati alcuni casi clinici di intersessualità.
Nella seconda parte dell’articolo, l’Autrice passa in rassegna i criteri finora utilizzati nella gestione delle ambiguità genitali (criterio somatico; criterio della praticabilità medico-chirurgica; criterio della prevalenza), proponendo il criterio diagnostico.
Clinical characteristics and efficacy of endoscopic treatment of gastrointestinal ectopic varices
Authors: Yipeng Wan , Anjiang Wang , Bimin Li , Chenkai Huang , Size Wan , Xuan Zhu 
Published: November 2020

Background:
Ectopic varices (EcVs) may cause massive bleeding, which can be difficult to control, with a high rate of mortality. The purpose of this study was to analyze the clinical characteristics of EcVs and the efficacy of endoscopic treatment.

Methods:
From January 2008 to July 2017, the clinical data of 150 patients with EcVs in our center were retrospectively collected and analyzed.

Results:
One hundred and fifty patients with EcVs (male 74.7%), with a mean age of: 54.1 ± 14.6 years were included. The prevalence of EcVs was 0.92% in gastrointestinal varices. Cirrhosis was the most common cause of EcVs (67.0%). The rates of bleeding were 57.14%, 4.34%, 30.0%, 33.3%, and 100% in the duodenal varices rectal varices, colonic varices, anastomotic varices, and small bowel varices, respectively. An age under 55 years, varices in the duodenum, and erythema were considered risk factors for EcV bleeding. Endoscopic treatments were performed in 15 patients with EcV bleeding. The follow-up period of the patients who underwent endoscopic treatment ranged from 0.5 to 24 months. The overall rate of treatment success was 73.33% for endoscopic treatment of EcV bleeding. The overall rates of rebleeding and mortality during 2 years were as high as 53.3% and 26.7%, respectively.

Conclusion:
Age, erythema, and the location of EcVs are considered risk factors for EcV bleeding, and the rate of bleeding is higher in patients with duodenal varices than in those with other EcVs. Endoscopic treatment is safe, effective, and feasible for controlling EcV bleeding.
Variation and Correlation between the Physical Properties of Dogwood Seeds
Authors: KALINIEWICZ Zdzisław 
Published: November 2020

Information about the physical properties of berries of selected dogwood species is available in the literature, but the basic physical traits of berry seeds have not been investigated to date. In this study, the terminal velocity, thickness, width, length, angle of external friction and mass of seeds of 11 dogwood species were measured. The measured parameters were used to calculate the geometric mean diameter, aspect ratio and sphericity index of each seed. The average values of the evaluated parameters were determined in the following range: terminal velocity - from 9.95 to 13.15 m s-1, thickness - from 3.31 to 5.02 mm, width - from 4.14 to 5.38 mm, length - from 4.33 to 11.55 mm, angle of external friction - from 9.97 to 29.85 ºC, mass - from 33.06 to 175.51 mg. The analyzed dogwood species were arranged in the following ascending order based on the geometric mean diameter of their seeds: Cornus macrophylla, Cornus alba, Cornus amonum, Cornus kousa, Cornus obliqua, Cornus controversa, Cornus walteri, Cornus sanguinea, Cornus florida, Cornus officinalis and Cornus mas. The seeds of Cornus alba, Cornus controversa, Cornus florida, Cornus kousa, Cornus macrophylla, Cornus mas and Cornus officinalis could be sorted with the use of mesh sieves with longitudinal openings, the seeds of Cornus macrophylla, Cornus sanguinea and Cornus walteri - with the use of mesh sieves with round openings, and the seeds of Cornus alba, Cornus macrophylla and Cornus obliqua - with the use of cylindrical graders.
O PORTUGUÊS QUE A ESCOLA FALA: UM RELATO DE EXPERIÊNCIA SOBRE O CONCEITO DE LÍNGUA PORTUGUESA NA ESCOLA PÚBLICA
Authors: Jesus da Silva Jadson Lima , Mendes Lenilza Teodoro dos Santos 
Published: November 2020

Este trabalho é fruto das experiências obtidas no estágio supervisionado em Língua Portuguesa pela Universidade Estadual de Santa Cruz – UESC. A turma na qual o trabalho foi realizado é do 6º ano do Ensino Fundamental II, da Escola Municipal São Pedro em Ilhéus-BA. Buscamos com este relato compartilhar e fomentar discussões acerca do conceito de língua na escola. O trabalho aqui apresentado tece algumas considerações sobre a maneira errônea como a gramática tradicional defrauda para si o conceito de língua. Ademais apresentamos aspectos relacionados à descrição do local, aulas, métodos utilizados, resultados obtidos, e uma reflexão sobre o conceito de língua nas aulas de Língua Portuguesa.
La Villa Bianca de Terragni. Panorámica temporal de una promenade architecturale
Authors: Carrau Carbonell Teresa , Bosch Reig Ignacio , Burgos Vijande Alberto 
Published: November 2020

<p>Durante su corta pero brillante carrera profesional, Terragni realizó algunos ejercicios residenciales, entre los que destaca la Villa Bianca en Seveso. A través de los dibujos del arquitecto racionalista, comprenderemos que verdaderamente la forma es el resultado de la función, que la envolvente responde a la resolución de las necesidades del hombre. Se analiza el estado inicial de la villa a través de la planimetría original, donde encontraremos las claves de esta villa, su evolución en el tiempo a través de la documentación gráfica inédita del arquitecto que la restauró y su estado actual mediante la experiencia de la visita in situ. Mediante el análisis comparativo de las planimetrías de las distintas épocas descubriremos cuál es su estado de conservación como patrimonio arquitectónico del Movimiento Moderno.</p>
Understanding processes that control dust spatial distributions with global climate models and satellite observations
Authors: Wu Mingxuan , Liu Xiaohong , Yu Hongbin , Wang Hailong , Shi Yang , Yang Kang , Darmenov Anton , Wu Chenglai , Wang Zhien , Luo Tao , Feng Yan , Ke Ziming 
Published: November 2020

Abstract. Dust aerosol is important in modulating the climate system at local and
global scales, yet its spatiotemporal distributions simulated by global
climate models (GCMs) are highly uncertain. In this study, we evaluate the
spatiotemporal variations of dust extinction profiles and dust optical depth
(DOD) simulated by the Community Earth System Model version 1 (CESM1) and
version 2 (CESM2), the Energy Exascale Earth System Model version 1
(E3SMv1), and the Modern-Era Retrospective analysis for Research and
Applications version 2 (MERRA-2) against satellite retrievals from
Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), Moderate
Resolution Imaging Spectroradiometer (MODIS), and Multi-angle Imaging
SpectroRadiometer (MISR). We find that CESM1, CESM2, and E3SMv1
underestimate dust transport to remote regions. E3SMv1 performs better than
CESM1 and CESM2 in simulating dust transport and the northern hemispheric
DOD due to its higher mass fraction of fine dust. CESM2 performs the worst
in the Northern Hemisphere due to its lower dust emission than in the other
two models but has a better dust simulation over the Southern Ocean due to
the overestimation of dust emission in the Southern Hemisphere. DOD from
MERRA-2 agrees well with CALIOP DOD in remote regions due to its higher mass
fraction of fine dust and the assimilation of aerosol optical depth. The
large disagreements in the dust extinction profiles and DOD among CALIOP,
MODIS, and MISR retrievals make the model evaluation of dust spatial
distributions challenging. Our study indicates the importance of
representing dust emission, dry/wet deposition, and size distribution in
GCMs in correctly simulating dust spatiotemporal distributions.