bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parametric dependencies of the yawed wind‐turbine wake development
Authors: Kleusberg Elektra , Schlatter Philipp , Henningson Dan S. 
Published: April 2020

AbstractYaw misalignment is currently being treated as one of the most promising methods for optimizing the power of wind farms. Therefore, detailed knowledge of the impact of yaw on the wake development is necessary for a range of operating conditions. This study numerically investigates the wake development behind a single yawed wind turbine operating at different tip‐speed ratios and yaw angles using the actuator‐line method in the spectral‐element code Nek5000. It is shown that depending on the tip‐speed ratio, the blade loading varies along the azimuth, resulting in a wake that is asymmetric in both the horizontal and vertical directions. Large tip‐speed ratios as well as large yaw angles are shown to decrease the vertical asymmetry of the yaw‐induced counter‐rotating vortex pair. Both parameters have the effect that they increase the spanwise force induced by yaw relative to the wake rotation. However, while the strength of the counter‐rotating vortex pair in the far wake increases with yaw angle, it is shown to decrease with the tip‐speed ratio. The vertical shift in the wake center is found to be highly dependent on the yaw angle and the tip‐speed ratio. These detailed insights into the yawed wake are important when optimizing potential downstream turbines.
Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective
Authors: Workman Paul 
Published: April 2020

AbstractThis personal perspective focuses on small-molecule inhibitors of proteostasis networks in cancer—specifically the discovery and development of chemical probes and drugs acting on the molecular chaperones HSP90 and HSP70, and on the HSF1 stress pathway. Emphasis is on progress made and lessons learned and a future outlook is provided. Highly potent, selective HSP90 inhibitors have proved invaluable in exploring the role of this molecular chaperone family in biology and disease pathology. Clinical activity was observed, especially in non small cell lung cancer and HER2 positive breast cancer. Optimal use of HSP90 inhibitors in oncology will likely require development of creative combination strategies. HSP70 family members have proved technically harder to drug. However, recent progress has been made towards useful chemical tool compounds and these may signpost future clinical drug candidates. The HSF1 stress pathway is strongly validated as a target for cancer therapy. HSF1 itself is a ligandless transcription factor that is extremely challenging to drug directly. HSF1 pathway inhibitors have been identified mostly by phenotypic screening, including a series of bisamides from which a clinical candidate has been identified for treatment of ovarian cancer, multiple myeloma and potentially other cancers.
Introduction
Authors: Peters Anne 
Published: April 2020

AbstractThe introduction explains key concepts and methods. It defines global animal law as the sum of legal rules and principles governing the interactions between humans and other animals, on a domestic, local, regional, and international level. Global animal law reacts to the mismatch between almost exclusively national animal-related legislation on the one hand, and the global dimension of the animal issue on the other hand. The merely national regulation of animal welfare within the states’ boundaries runs aloof in the face of globalisation. This gives rise to an animal welfare gap. Moreover, animal use creates global problems ranging from climate and soil degradation over antimicrobial resistance to food insecurity. This requires a global law response. The introduction also gives a brief overview over the book and its main findings.
(Certified) Humane Violence? Animal Production, the Ambivalence of Humanizing the Inhumane, and What International Humanitarian Law Has to Do with It
Authors: Stucki Saskia 
Published: April 2020

AbstractThe chapter draws a comparison with the self-certifying of production methods as ‘humane’ or animal-friendly in the labelling of animal products—that is, according to companies’ own self-imposed codes of conduct. It likens the idea of humanizing animal slaughter, factory farms, and other forms of production to the notion of humanizing warfare. Like international humanitarian law (IHL), animal welfare law is marked by the tension inherent in its attempt to humanize innately inhumane practices. Given these parallels, the analysis of animal welfare law might benefit from existing insights into the potential and limits of IHL. Both areas of law endorse a principle of ‘humanity’ while arguably facilitating and legitimizing the use of violence, and might thereby ultimately perpetuate the suffering of living beings. The implicit justification of violence percolating from the IHL-like animal ‘protection’ laws could only be outweighed by complementing this body of law with a ius contra bellum for animals.
Trophy Hunting, the Race to the Bottom, and the Law of Jurisdiction
Authors: Blattner Charlotte E. 
Published: April 2020

AbstractCross-border trade, industry outsourcing, and animal migration are increasingly challenging states that want to take their commitment to protecting animals seriously. When multinationals threaten to outsource, even the most powerful states succumb to economic pressure and give corporations what they so avidly desire: laissez-faire. Some argue this is an inevitable consequence of globalization; others say it prompts us to question whether animal law is not better off being regulated by international law. This chapter takes a third path. Instead of proposing that nations seek agreement on low and mostly ineffective animal welfare standards, it posits extraterritorial jurisdiction as a promising avenue for animal law, and takes trophy hunting as its example to illustrate the many jurisdictional options for states to overcome regulatory gaps in animal law and make animal issues more visible on the international plane.
China’s Legal Response to Trafficking in Wild Animals: The Relationship between International Treaties and Chinese Law
Authors: Chang Jiwen 
Published: April 2020

AbstractThe chapter gives an account of China’s new legal framework (particularly the Wild Animal Protection Law of 2016). This comprises novel official decrees which interpret the criminal law, law enforcement activities (partly police operations conducted jointly with other states), new injunctions banning ivory products, and finally criminal prosecutions. However, gaps and deficiencies persist in China’s law on the books, enforcement remains slow and patchy, and international cooperation is not strong. Chang suggests several concrete measures for improvement, including the introduction of public interest litigation, better coordination among governmental departments, a trading information platform, and consultation with the secretariat of the Convention on International Trade in Endangered Species of Wild Flora and Fauna (CITES), in order to bring the Chinese legal and administrative framework fully in line with CITES.
Stochastic Tamed Navier–Stokes Equations on $${\mathbb {R}}^3$$: The Existence and the Uniqueness of Solutions and the Existence of an Invariant Measure
Authors: Brzeźniak Zdzisław , Dhariwal Gaurav 
Published: April 2020

AbstractRöckner and Zhang (Probab Theory Relat Fields 145, 211–267, 2009) proved the existence of a unique strong solution to a stochastic tamed 3D Navier–Stokes equation in the whole space and for the periodic boundary case using a result from Stroock and Varadhan (Multidimensional diffusion processes, Springer, Berlin, 1979). In the latter case, they also proved the existence of an invariant measure. In this paper, we improve their results (but for a slightly simplified system) using a self-contained approach. In particular, we generalise their result about an estimate on the $$L^4$$

L
4

-norm of the solution from the torus to $${\mathbb {R}}^3$$

R

3

, see Lemma 5.1 and thus establish the existence of an invariant measure on $${\mathbb {R}}^3$$

R

3

for a time-homogeneous damped tamed 3D Navier–Stokes equation, given by (6.1).
Radiomics for liver tumours
Authors: Dreher Constantin , Linde Philipp , Boda-Heggemann Judit , Baessler Bettina 
Published: April 2020

AbstractCurrent research, especially in oncology, increasingly focuses on the integration of quantitative, multiparametric and functional imaging data. In this fast-growing field of research, radiomics may allow for a more sophisticated analysis of imaging data, far beyond the qualitative evaluation of visible tissue changes. Through use of quantitative imaging data, more tailored and tumour-specific diagnostic work-up and individualized treatment concepts may be applied for oncologic patients in the future. This is of special importance in cross-sectional disciplines such as radiology and radiation oncology, with already high and still further increasing use of imaging data in daily clinical practice. Liver targets are generally treated with stereotactic body radiotherapy (SBRT), allowing for local dose escalation while preserving surrounding normal tissue. With the introduction of online target surveillance with implanted markers, 3D-ultrasound on conventional linacs and hybrid magnetic resonance imaging (MRI)-linear accelerators, individualized adaptive radiotherapy is heading towards realization. The use of big data such as radiomics and the integration of artificial intelligence techniques have the potential to further improve image-based treatment planning and structured follow-up, with outcome/toxicity prediction and immediate detection of (oligo)progression. The scope of current research in this innovative field is to identify and critically discuss possible application forms of radiomics, which is why this review tries to summarize current knowledge about interdisciplinary integration of radiomics in oncologic patients, with a focus on investigations of radiotherapy in patients with liver cancer or oligometastases including multiparametric, quantitative data into (radio)-oncologic workflow from disease diagnosis, treatment planning, delivery and patient follow-up.
Performance of an acoustic settler versus a hollow fiber–based ATF technology for influenza virus production in perfusion
Authors: Gränicher Gwendal , Coronel Juliana , Trampler Felix , Jordan Ingo , Genzel Yvonne , Reichl Udo 
Published: April 2020

Abstract
Process intensification and integration is crucial regarding an ever increasing pressure on manufacturing costs and capacities in biologics manufacturing. For virus production in perfusion mode, membrane-based alternating tangential flow filtration (ATF) and acoustic settler are the commonly described cell retention technologies. While acoustic settlers allow for continuous influenza virus harvesting, the use of commercially available membranes for ATF systems typically results in the accumulation of virus particles in the bioreactor vessel. Accordingly, with one single harvest at the end of a cultivation, this increases the risk of lowering the product quality. To assess which cell retention device would be most suitable for influenza A virus production, we compared various key performance figures using AGE1.CR.pIX cells at concentrations between 25 and 50 × 106 cells/mL at similar infection conditions using either an ATF system or an acoustic settler. Production yields, process-related impurities, and aggregation of viruses and other large molecules were evaluated. Taking into account the total number of virions from both the bioreactor and the harvest vessel, a 1.5–3.0-fold higher volumetric virus yield was obtained for the acoustic settler. In addition, fewer large-sized aggregates (virus particles and other molecules) were observed in the harvest taken directly from the bioreactor. In contrast, similar levels of process-related impurities (host cell dsDNA, total protein) were obtained in the harvest for both retention systems. Overall, a clear advantage was observed for continuous virus harvesting after the acoustic settler operation mode was optimized. This development may also allow direct integration of subsequent downstream processing steps.

Key points
• High suspension cell density, immortalized avian cell line, influenza vaccine.
Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach
Authors: Barrett Hilary E. , Meester Eric J. , van Gaalen Kim , van der Heiden Kim , Krenning Boudewijn J. , Beekman Freek J. , de Blois Erik , de Swart Jan , Verhagen H J , Maina Theodosia , Nock Berthold A. , Norenberg Jeffrey P. , de Jong Marion , Gijsen Frank J. H. , Bernsen Monique R. 
Published: April 2020

Abstract
Purpose
Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer’s capability to identify plaque phenotype and inflammation levels pertaining to leukocytes expressing leukocyte function-associated antigen-1 (LFA-1) and the leukocyte subset of proinflammatory macrophages expressing somatostatin receptor subtype-2 (SST2). Individual radiotracer uptake was quantified and the presence of corresponding immunohistological cell markers was assessed.

Methods
Human symptomatic carotid plaque segments were obtained from endarterectomy. Segments were incubated in dual-isotope radiotracers [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt) and [99mTc]Tc-[N0–14,Asp0,Tyr3]-octreotate ([99mTc]Tc-Demotate 2) before scanning with SPECT/CT. Plaque phenotype was classified as pathological intimal thickening, fibrous cap atheroma or fibrocalcific using histology sections based on distinct morphological characteristics. Plaque segments were subsequently immuno-stained with LFA-1 and SST2 and quantified in terms of positive area fraction and compared against the corresponding SPECT images.

Results
Focal uptake of co-localising dual-radiotracers identified the heterogeneous distribution of inflamed regions in the plaques which co-localised with positive immuno-stained regions of LFA-1 and SST2. [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake demonstrated a significant positive correlation (r = 0.651; p = 0.001). Fibrous cap atheroma plaque phenotype correlated with the highest [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake compared with fibrocalcific plaques and pathological intimal thickening phenotypes, in line with the immunohistological analyses.

Conclusion
A dual-isotope acquisition protocol permits the imaging of multiple leukocyte subsets and the pro-inflammatory macrophages simultaneously in atherosclerotic plaque tissue. [111In]In-Danbirt may have added value for assessing the total inflammation levels in atherosclerotic plaques in addition to classifying plaque phenotype.
Refrigeration or anti-theft? Food-caching behavior of wolverines (Gulo gulo) in Scandinavia
Authors: van der Veen Bert , Mattisson Jenny , Zimmermann Barbara , Odden John , Persson Jens 
Published: April 2020

AbstractFood-caching animals can gain nutritional advantages by buffering seasonality in food availability, especially during times of scarcity. The wolverine (Gulo gulo) is a facultative predator that occupies environments of low productivity. As an adaptation to fluctuating food availability, wolverines cache perishable food in snow, boulders, and bogs for short- and long-term storage. We studied caching behavior of 38 GPS-collared wolverines in four study areas in Scandinavia. By investigating clusters of GPS locations, we identified a total of 303 food caches from 17 male and 21 female wolverines. Wolverines cached food all year around, from both scavenging and predation events, and spaced their caches widely within their home range. Wolverines cached food items on average 1.1 km from the food source and made between 1 and 6 caches per source. Wolverines cached closer to the source when scavenging carcasses killed by other large carnivores; this might be a strategy to optimize food gain when under pressure of interspecific competition. When caching, wolverines selected for steep and rugged terrain in unproductive habitat types or in forest, indicating a preference for less-exposed sites that can provide cold storage and/or protection against pilferage. The observed year-round investment in caching by wolverines underlines the importance of food predictability for survival and reproductive success in this species. Increasing temperatures as a consequence of climate change may provide new challenges for wolverines by negatively affecting the preservation of cached food and by increasing competition from pilferers that benefit from a warmer climate. It is however still not fully understood which consequences this may have for the demography and behavior of the wolverine.Significance statementFood caching is a behavioral strategy used by a wide range of animals to store food for future use. Choosing appropriate caching sites appears important for slowing down decomposition rates and minimizes competition. In this study, we demonstrate that the wolverine, an opportunistic predator and scavenger, utilizes available carrion to create caches all year around. By following wolverines with GPS collars, we registered that they carried food far away to cache it in secluded and cold places, which are often located on steep slopes or in forest. However, when scavenging other carnivores’ prey, they move food in shorter distances, possibly to be able to quickly return for more. The observed efficiency in wolverine caching behavior is likely vital for their survival and reproductive success in the harsh and highly seasonal environment in which they live.
Mechanism of thrombocytopenia in COVID-19 patients
Authors: Xu Panyang , Zhou Qi , Xu Jiancheng 
Published: April 2020

AbstractSince December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options.
Comparison of magnetron sputtering and ion beam sputtering on dispersive mirrors
Authors: Chen Y. , Hahner D. , Trubetskov M. , Schrameyer S. , Sakiew W. , Starke K. , Pervak V. 
Published: April 2020

AbstractWe have compared two kinds of dispersive mirrors (DMs) produced by magnetron sputtering and ion beam sputtering. One of them is a broadband DM which is known as double-angle DM, providing a group delay dispersion (GDD) of $$-40 \mathrm{{fs}}^2$$-40fs2 in the range of 550–1050 nm. The other one is a robust highly dispersive mirror, which provides a GDD of about $$-275 \mathrm{{fs}}^2$$-275fs2 at 800 nm and covers the wavelength range from 690 to 890 nm. For the first time, a comparison between magnetron-sputtering-produced and ion-beam-sputtering-produced dispersive mirrors is performed.
Left atrial appendage closure in patients with chronic kidney disease: results from the German multicentre LAARGE registry
Authors: Fastner Christian , Brachmann Johannes , Lewalter Thorsten , Zeymer Uwe , Sievert Horst , Borggrefe Martin , Nienaber Christoph A. , Weiß Christian , Pleger Sven T. , Ince Hüseyin , Maier Jens , Achenbach Stephan , Sigusch Holger H. , Hochadel Matthias , Schneider Steffen , Senges Jochen , Akin Ibrahim 
Published: April 2020

Abstract
Objectives
Chronic kidney disease (CKD) is associated with an increased complication rate after cardiac interventions. Although CKD has a high prevalence among atrial fibrillation patients, the impact of CKD on periprocedural complications and the outcome after an interventional left atrial appendage closure (LAAC) is unclear. The present study, therefore, aimed to investigate whether CKD influences the procedure’s effectiveness and safety.

Methods
LAARGE is a prospective, non-randomised registry. LAAC was conducted with different standard commercial devices, and the follow-up period was one year. CKD was defined by an eGFR < 60 mL/min/1.73 m2, and subgroups were further analysed (i.e. eGFR < 15, 15–29, and 30–59 mL/min/1.73 m2, respectively).

Results
Two hundred ninety-nine of 623 patients (48.0%) revealed a CKD. The prevalence of cardiovascular comorbidity, CHA2DS2-VASc score (4.9 vs. 4.2), and HAS-BLED score (4.3 vs. 3.5) was significantly higher in CKD patients (each p < 0.001). Implantation success was similarly high across all GFR groups (97.9%). Periprocedural MACCE (0.7 vs. 0.3%), and other major complications (4.7 vs. 3.7%) were comparably infrequent. Survival free of stroke was significantly lower among CKD patients within 1 year (82.0 vs. 93.0%; p < 0.001; consistent after adjustment for confounding factors), without significant accentuation in advanced CKD (i.e. eGFR < 30 mL/min/1.73 m2; p > 0.05  vs. eGFR 30–59 mL/min/1.73 m2). Non-fatal strokes were absolutely infrequent during follow-up (0 vs. 1.1%). Severe non-fatal bleedings were observed only among CKD patients (1.4 vs. 0%; p = 0.021).

Conclusions
Despite an increased cardiovascular risk profile of CKD patients, device implantation was safe, and LAAC was associated with effective stroke prevention across all CKD stages.
Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias
Authors: Albers Max B. , Almquist Martin , Bergenfelz Anders , Nordenström Erik 
Published: April 2020

Abstract
Purpose
Surgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date.

Methods
Data of patients with GEP-NENs operated between January 2015 and September 2018 were retrieved from EUROCRINE©, a European online endocrine surgical quality registry, and analyzed regarding rate and risk factors of surgical complications. Risk factors were assessed by logistic regression.

Results
Some 376 patients (211 female, 167 male; age median 63, range 15–89 years) were included. Most NENs were located in the small intestine (SI) (n = 132) or pancreas (n = 111), the rest in the stomach (n = 34), duodenum (n = 30), appendix (n = 30), colon, and rectum (n = 22), or with unknown primary (n = 15). Of the tumors, 320 (85.1%) were well or moderately differentiated, and 147 (39.1%) of the patients had distant metastases at the time of operation. Severe complications (Dindo-Clavien ≥ 3) occurred in 56 (14.9%) patients, and 4 (1.1%) patients died perioperatively. Severe complications were more frequent in surgery for duodenopancreatic NENs (n = 31; 22.0%) compared with SI-NENs (n = 15; 11.4%) (p = 0.014), in patients with lymph node metastases operated with curative aim of surgery (n = 24; 21.4%) versus non-metastasized tumors or palliative surgery (n = 32; 12.1%) (p = 0.020), and in functioning tumors (n = 20; 23.0%) versus non-functioning tumors (n = 30; 13.5%) (p = 0.042). Complication rates were not significantly associated with tumor stage or grade.

Conclusions
Severe complications are frequent in GEP-NEN surgery. Besides duodenopancreatic tumor location, curative resection of nodal metastases and functioning tumors are risk factors for complications.