bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrast‐enhanced voiding urosonography: A new, radiation‐free, alternative method for imaging of urinary bladder and urethra in healthy dogs
Authors: Trikoupi Georgia , Papadopoulou Paraskevi , Papadopoulou Frederica , Theodoridis Alexandros , Papazoglou Lysimachos , Patsikas Michael 
Published: May 2020

AbstractContrast‐enhanced voiding urosonography (CE‐VUS) has been generally considered as a promising tool to diagnose vesicoureteral reflux and abnormalities in lower urinary tract in human patients, especially in children. The purpose of this prospective study is to evaluate the quality of images of the urinary bladder and urethra obtained by CE‐VUS using a second‐generation ultrasound contrast agent (SonoVue®) in healthy dogs and to investigate the safety profile of SonoVue® after intravesical administration. Eighty‐four CE‐VUS examinations with SonoVue® were successfully performed in both unsedated (39/84) and sedated (45/84) dogs. Contrast‐enhanced voiding urosonography examination of urinary bladder was technically successful in all (84/84) dogs. The image quality was not considered adequate in five (5/84) dogs including three dogs in whom layering of contrast media during filling phase was observed and two dogs with premature destruction of microbubbles. In these five dogs, the problem was readily recognized and corrected such that the procedure was still successfully undertaken. The assessment of the urethra during spontaneous micturition was successfully performed in all (84/84) dogs in whom voiding was elicited during the examination. No side effects were observed after intravesical application of SonoVue®. This study demonstrates that CE‐VUS is a feasible and valuable technique to evaluate low urinary tract morphology and function in dogs. Based on our review of the literature, there are no published reports about the use of this method in dogs.
Impact of persulphate mixed with paper sludge on activated sludge dewaterability
Authors: Wang Sen , Cheng Saige , Xiao Xueli , Lai Fan 
Published: May 2020

AbstractFeSO4 was used to activate K2S2O8 mixed with paper sludge to condition activated sludge, and its effect on sludge dewaterability was investigated. Interaction effects of various parameters on sludge dewaterability were investigated and analysed by considering the moisture content of cake, specific resistance to filtration (SRF) and capillary suction time (CST) as indicators and the Box–Behnken design of response surface methodology (RSM). Results indicated that the moisture content of cake, SRF and CST decreased from 74.52 to 69.57%, 25.39 × 1012 to 11.80 × 1012 m/kg and 199.8 to 146.4 s, respectively, under optimal conditions. RSM results presented that only 0.13% of the response values cannot be interpreted with this model, and the three‐factor interaction was observed to be significant. Additionally, sludge dewaterability mechanism observed that K2S2O8 mixed with paper sludge used the strong oxidising properties of SO4−• to crack sludge flocs. Fine fibres and calcium carbonate in the paper sludge played important roles as the skeleton support in the sludge filtration process, and the internal moisture was rapidly eliminated.
Delayed presentation of acute ischemic strokes during the COVID-19 crisis
Authors: Schirmer Clemens M , Ringer Andrew J , Arthur Adam S , Binning Mandy J , Fox W Christopher , James Robert F , Levitt Michael R , Tawk Rabih G , Veznedaroglu Erol , Walker Melanie , Spiotta Alejandro M 
Published: May 2020

BackgroundThe COVID-19 pandemic has disrupted established care paths worldwide. Patient awareness of the pandemic and executive limitations imposed on public life have changed the perception of when to seek care for acute conditions in some cases. We sought to study whether there is a delay in presentation for acute ischemic stroke patients in the first month of the pandemic in the US.MethodsThe interval between last-known-well (LKW) time and presentation of 710 consecutive patients presenting with acute ischemic strokes to 12 stroke centers across the US were extracted from a prospectively maintained quality database. We analyzed the timing and severity of the presentation in the baseline period from February to March 2019 and compared results with the timeframe of February and March 2020.ResultsThere were 320 patients in the 2-month baseline period in 2019, there was a marked decrease in patients from February to March of 2020 (227 patients in February, and 163 patients in March). There was no difference in the severity of the presentation between groups and no difference in age between the baseline and the COVID period. The mean interval from LKW to the presentation was significantly longer in the COVID period (603±1035 min) compared with the baseline period (442±435 min, P<0.02).ConclusionWe present data supporting an association between public awareness and limitations imposed on public life during the COVID-19 pandemic in the US and a delay in presentation for acute ischemic stroke patients to a stroke center.
The DeLeaves: a UAV device for efficient tree canopy sampling
Authors: Charron Guillaume , Robichaud-Courteau Thomas , La Vigne Hughes , Weintraub Samantha , Hill Andy , Justice Douglas , Bélanger Nicolas , Lussier Desbiens Alexis 
Published: May 2020

Tree canopy sampling is critical in many forestry-related applications, including ecophysiology, foliar nutrient diagnostics, remote sensing model development, genetic analysis, and biodiversity monitoring and conservation. Many of these applications require foliage samples that have been exposed to full sunlight. Unfortunately, current sampling techniques are severely limited in cases where site topography (e.g., rivers, cliffs, canyons) or tree height (i.e., branches located above 10 m) make it time-consuming, expensive, and possibly hazardous to collect samples. This paper reviews the recent developments related to unmanned aerial vehicle (UAV) based tree sampling and presents the DeLeaves tool, a new device that can be installed under a small UAV to efficiently sample small branches in the uppermost canopy (i.e., <25 mm stem diameter, <500 g total weight, any orientation). Four different sampling campaigns using the DeLeaves tool are presented to illustrate its real-life use in various environments. So far, the DeLeaves tool has been able to collect more than 250 samples from over 20 different species with an average sampling time of 6 min. These results demonstrate the potential of UAV-based tree sampling to greatly enhance key tasks in forestry, botany, and ecology.
Tectonic history across the Iapetus suture zone in Ireland
Authors: McConnell Brian , Riggs Nancy , Fritschle Tobias 
Published: May 2020

Abstract
The early Paleozoic rocks of eastern Ireland span the suture zone between the Laurentian and Ganderian continental margins of the Iapetus Ocean. The Grangegeeth Terrane comprises a Laurentian continental fragment and Ordovician volcanic arc that formed the southern margin of the late Ordovician Rathkenny Basin of Moffat Shale facies mudstone. Together, these were overstepped in Wenlock time by Laurentia-derived greywackes and became the southernmost tract of the Longford–Down Terrane accretionary prism as subduction brought them into the Laurentian-margin trench. South of the suture, Middle Ordovician failed rifting of a Ganderian volcanic arc terrane was followed by shortening during continuing subduction under the north-facing arc. In Newfoundland, a Ganderian volcanic arc migrated across the ocean in mid-Ordovician times to accrete to Laurentia. In Ireland, the late-accreted arc on the Laurentian margin was formed on a Laurentian microcontinent, and Ganderia had an active margin throughout Late Ordovician time. Silurian closure of Iapetus was between the leading edge of Ganderia and the Laurentian margin, unlike in the Canadian Appalachians, where separate Ordovician and Silurian sutures are recognized. Iapetus was narrow by Katian time but subduction-related magmatism continued into Wenlock times on both margins.
Generating Representative Test Sequences from Real Workload for Minimizing DRAM Verification Overhead
Authors: Paik Yoonah , Kim Seon Wook , Jung Dongha , Kim Minseong 
Published: May 2020

Dynamic Random Access Memory (DRAM) standards have evolved for higher bandwidth, larger capacity, and lower power consumption, so their specifications have become complicated to satisfy the design goals. These complex implementations have significantly increased the test time overhead for design verification; thus, a tremendous amount of command sequences are used. However, since the sequences generated by real machines or memory simulators are the results of scheduling for high performance, they result in low test coverage with repetitive patterns. Eventually, various workloads should be applied to increase the coverage, but this approach incurs significant test time overhead. A few preliminary studies have been proposed to generate predefined or random sequences to cover various test cases or increase test coverage. However, they have limitations in representing various memory behaviors of real workloads.
In this article, we define a performance metric for estimating the test coverage when using command sequences. Then, our experiment shows that the coverage of a real machine and a simulator is low and similar. Also, the coverage patterns are almost the same in all tested benchmarks. To alleviate the problem, we propose a test-oriented command scheduling algorithm that increases the test coverage while preserving the memory behaviors of workloads and reducing the test time overhead by extracting representative sequences based on the similarity between command sequences. For the sequence extraction and the coverage estimation, our test sequences are embedded into vectors using bag-of-Ngrams. Compared to the simulator, our algorithm achieves 2.94x higher coverage while reducing the test overhead to 7.57%.
Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope
Authors: van Dijk J. Gert , Ghariq Maryam , Kerkhof Fabian I. , Reijntjes Robert , van Houwelingen Marc J. , van Rossum Ineke A. , Saal Dirk P. , van Zwet Erik W. , van Lieshout Johannes J. , Thijs Roland D. , Benditt David G. 
Published: May 2020

Rationale:
Assessing the relative contributions of cardioinhibition and vasodepression to the blood pressure (BP) decrease in tilt-induced vasovagal syncope requires methods that reflect BP physiology accurately.

Objective:
To assess the relative contributions of cardioinhibition and vasodepression to tilt-induced vasovagal syncope using novel methods.

Methods and Results:

We studied the parameters determining BP, that is, stroke volume (SV), heart rate (HR), and total peripheral resistance (TPR), in 163 patients with tilt-induced vasovagal syncope documented by continuous ECG and video EEG monitoring. We defined the beginning of cardioinhibition as the start of an HR decrease (HR) before syncope and used logarithms of SV, HR, and TPR ratios to quantify the multiplicative relation BP=SV·HR·TPR. We defined 3 stages before syncope and 2 after it based on direction changes of these parameters. The earliest BP decrease occurred 9 minutes before syncope. Cardioinhibition was observed in 91% of patients at a median time of 58 seconds before syncope. At that time, SV had a strong negative effect on BP, TPR a lesser negative effect, while HR had increased (all
P
<0.001). At the onset of cardioinhibition, the median HR was at 98 bpm higher than baseline. Cardioinhibition thus initially only represented a reduction of the corrective HR increase but was nonetheless accompanied by an immediate acceleration of the ongoing BP decrease. At syncope, SV and HR contributed similarly to the BP decrease (
P
<0.001), while TPR did not affect BP.

Conclusions:
The novel methods allowed the relative effects of SV, HR, and TPR on BP to be assessed separately, although all act together. The 2 major factors lowering BP in tilt-induced vasovagal syncope were reduced SV and cardioinhibition. We suggest that the term vasodepression in reflex syncope should not be limited to reduced arterial vasoconstriction, reflected in TPR, but should also encompass venous pooling, reflected in SV.
China’s Efforts in Marine Biodiversity Conservation: Recent Developments in Policy and Institutional Reform
Authors: Wang Jiayi , Zou Keyuan 
Published: May 2020

Abstract
Marine biodiversity is essential for providing material foundations for sustainable social development and maintaining balance in the ecosystems of the earth. However, in recent years, marine biodiversity has been threatened by the combined effects of human activities and climate change, and has deteriorated at both domestic and international levels. Effective marine biodiversity conservation is dependent upon a comprehensive policy and legislation framework and scientific conservation measures. As a responsible developing country, China has made great efforts to protect marine biodiversity. This article provides an overview of recent policy and institutional developments in China with respect to marine biodiversity conservation. These current developments indicate that China’s marine biodiversity conservation strategy is increasingly holistic and unified, and emphasises integrated management of the sea.
Global Characterization of the Ocean’s Internal Wave Spectrum
Authors: Pollmann Friederike 
Published: May 2020

AbstractA key ingredient of energetically consistent ocean models is the parameterized link between small-scale turbulent mixing, an important energy source of large-scale ocean dynamics, and internal gravity wave energetics. Theory suggests that this link depends on the wave field’s spectral characteristics, but because of the paucity of suitable observations, its parameterization typically relies on a model spectrum [Garrett–Munk (GM)] with constant parameters. Building on the so-called “finestructure method,” internal gravity wave spectra are derived from vertical strain profiles obtained from Argo floats to provide a global estimate of the spatial and temporal variability of the GM model’s spectral parameters. For spectral slopes and wavenumber scales, the highest variability and the strongest deviation from the model’s canonical parameters are observed in the North Atlantic, the northwest Pacific, and the Southern Ocean. Internal wave energy levels in the upper ocean are well represented by the GM model value equatorward of approximately 50°, while they are up to two orders of magnitude lower poleward of this latitude. The use of variable spectral parameters in the energy level calculation hides the seasonal cycle in the northwest Pacific that was previously observed for constant parameters. The global estimates of how the GM model’s spectral parameters vary in space and time are hence expected to add relevant detail to various studies on oceanic internal gravity waves, deepening the understanding of their energetics and improving parameterizations of the mixing they induce.
Positional headache induced by isolated middle cerebral artery dissection: Two case reports
Authors: Lee Sang-Hun , Yeo Tae-Young , Jung Jin-Man 
Published: May 2020

Background Isolated middle cerebral artery dissection is uncommon and occurs in patients reporting headaches as the only symptom. This makes intracranial artery dissection challenging to diagnose and treat. Case description: We describe two cases of positional headache caused by isolated middle cerebral artery dissection, confirmed using high-resolution magnetic resonance imaging. The two patients presented with sudden-onset headache, occurring when lying in the lateral decubitus position. When lying down in the decubitus position ipsilateral to the intracranial artery dissection, the headache aggravated and middle cerebral artery flow velocity increased on transcranial Doppler ultrasonography compared to when in the supine position. Both patients were treated with antiplatelet agents, and the headache completely resolved within 1–2 weeks. Conclusion We recommend additional imaging studies evaluating intracranial artery dissection as a cause of positional headache.
Pediatric Cardiac Critical Care Transport and Palliative Care: A Case Series
Authors: Garcia Xiomara , Frazier Elizabeth , Kane Janie , Jones Amber , Brown Carrie , Bryant Tonja , Prodhan Parthak 
Published: May 2020

Objective: To present our center’s experience with terminal extubation in 3 palliative critical care home transports from the Pediatric Cardiac Intensive Unit. Design: All cases were identified from our Cardiovascular intensive care unit ( CVICU). Patients were terminally ill children with no other surgical or medical option who were transported home between 2014 and 2018, for terminal extubation and end-of-life care according to their families’ wishes. Interventions: The patients were 7, 9 months, and 19 years; and they had very complex and chronic conditions. The families were approached by the CVICU staff during multidisciplinary meetings, where goals of care were established. Parental expectations were clarified, and palliative care team was involved, as well as home hospice was arranged pre transfer. The transfer process was discussed and all the needs were established. All patients had unstable medical conditions, with needs for transport for withdrawal of life support and death at home. Each case needed a highly trained team to support life while in transport. The need of these patients required coordination with home palliative care services, as well as community resources due to difficulty to get in their homes. Conclusions: Transportation of pediatric cardiac critical care patients for terminal extubation at home is a relatively infrequent practice. It is a feasible alternative for families seeking out of the hospital end-of-life care for their critically ill and technology dependent children. Our single-center experience supports the need for development of formal programs for end-of-life critical care transports.
Appetite-stimulating effect of gabapentin vs mirtazapine in healthy cats post-ovariectomy
Authors: Fantinati Marco , Trnka Julien , Signor Amélia , Dumond Séverine , Jourdan Géraldine , Verwaerde Patrick , Priymenko Nathalie 
Published: May 2020

Objectives The aim of the study was to evaluate the appetite-stimulating effect of gabapentin by comparing it with mirtazapine in healthy cats in the first 8 h after ovariectomy surgery. Methods This double-masked, placebo-controlled, prospective clinical trial included 60 healthy cats presented to the hospital for ovariectomy: 20 received gabapentin, 21 received mirtazapine and 19 received a placebo immediately before and 6 h after surgery. Food was offered at 2, 4, 6 and 8 h post-ovariectomy. After each meal, food intake was measured. Data were analysed using repeated-measure ANOVA and a linear mixed-model analysis. Post-hoc Tukey’s honest significant difference test was performed for multiple comparisons. Results Food intake increased in both treatment groups vs placebo. No statistically significant difference was found between cats treated with gabapentin or mirtazapine. Conclusions and relevance Cats receiving gabapentin ate more than cats in the placebo group. Thirty percent of cats in the gabapentin group covered their resting energy requirements, while none of the cats in the placebo group did. Gabapentin and mirtazapine produced similar effects on food intake.
Epstein–Barr virus retinitis in an immunocompromised child: A case report
Authors: Chou Hung-Da , Teh Wee Min , Sun Ming-Hui , Chen Kuan-Jen 
Published: May 2020

Introduction The Epstein–Barr virus is a rare causative pathogen identified in the posterior segment. The majority of cases were presented with a serious condition of acute retinal necrosis, and most of these eyes had poor outcomes. The clinical features and effective treatment options for this condition are still unclear. Case description: A 10-year-old boy with leukaemia and receiving immunosuppressive regimen presented with decreasing visual acuity to counting fingers in his left eye for 2 weeks. Fundus examination revealed disc swelling, retinitis, retinal exudates and haemorrhages. Aqueous polymerase chain reaction was positive for Epstein–Barr virus DNA but negative for cytomegalovirus, herpes simplex virus and varicella zoster virus DNA. Systemic acyclovir and intravitreal ganciclovir injection were administered. Seven months later, retinitis resolved with remnant retinal fibrosis, and visual acuity improved to 20/500. Conclusion Epstein–Barr virus is rarely identified as a sole pathogen in retinitis. Peripapillary predilection might be another type of presenting feature apart from the more-commonly reported peripheral acute retinal necrosis.
Knowledge, Awareness, and Perception of Community Pharmacists to Zika Virus Infection in Klang Valley, Malaysia
Authors: Lim Kah Yee , Tham Hong-Wai 
Published: May 2020

Background: Zika fever is a mosquito-borne disease with global health concern. It has been underreported or misdiagnosed due to its unspecific clinical manifestations, including mild-influenza like and subclinical symptoms. However, its associated serious complications which include fetal microcephaly and Guillain-Barré syndrome remained a challenge to the public health sectors. This research aimed to evaluate the knowledge, awareness, and perception toward Zika virus infection among community pharmacists in the Klang Valley of Malaysia and to determine the association between the knowledge of Zika virus infectious disease and years of community practice experience among community pharmacists in this region. Methods: This survey research was conducted from August to December 2018 through a pre-tested, self-administration, and cross-sectional random convenient sampling at various districts in the Klang Valley. A total of 275 registered community pharmacists were involved in this study by completing a pilot-tested questionnaire. Descriptive analysis, Mann-Whitney U test, and Kruskal-Wallis H test were used to analyze the data. Results: The knowledge toward Zika virus infection of respondents was classified into “poor” (5.1%), “basic” (70.9%), and “broad” (24.0%). Most of the participants (n = 195, 70.9%) presented with basic knowledge toward Zika virus infection. A total of 268 (97.5%) participants presented with high awareness toward Zika virus infection. The mean score of respondents’ knowledge and awareness was 15.88 ± 3.61 (maximum score = 28) and 13.96 ± 1.60 (maximum score = 16), respectively. There was a statistically significant difference between the years of practice of community pharmacists and the level of knowledge toward Zika virus infection. Conclusions: In conclusion, our respondents demonstrated a basic level of knowledge and high awareness toward Zika virus infection. Also, we highlighted some possible pitfalls in the knowledge of Zika virus infection, including the virus transmission, symptoms, diagnosis, treatment, prevention, and complications of the disease.