bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Case of Autoimmune Hemolytic Anemia Caused by Warm-reacting IgM-class Antibodies Associated with Mycoplasma Pneumoniae Infection
Authors: Abdelmonem M , Wasim H , Abdelmonem M 
Published: October 2020

Abstract

Introduction/Objective
Warm autoantibodies are usually IgG-class and/or IgA-class immunoglobulins. may be classified as agglutinins or hemolysins, which may be incomplete or complete, depending on in vitro serology; they almost always bind complement. Autoimmune hemolytic anemia with only warm IgM autoantibodies is extremely rare.

Methods
A 91-year-old Caucasian male with hypertension presented with non-productive cough for two weeks, associated with shortness of breath and fatigue. He has a paste history of medical history of high degree AV block with sick sinus syndrome and bradycardia.

Results
He had blood pressure of 111/53 and heart rate of 50. Laboratory investigations showed leukocytes count of 7, Hemoglobin level of 5.6 g/dl, hematocrit level of 15.5%, platelets count of 267, total bilirubin of 5.6 mg/dL, direct bilirubin of 0.7 mg/dL, and lactate dehydrogenase (LDH) of 372 U/L and IgM titer for Mycoplasma pneumoniae was 1493 units/mL (Ref &lt; 770). He was transfused four units of packed red blood cells as emergency release due to a positive antibody screen. His hemoglobin level increased from 5.6 g/dL to 7.2 g/dL then it decreased from 8.2 g/dL to 5.6 g/dL the next two days. Direct antiglobulin test was 3+ positive for C3d and Negative for IgG. He finished a 7-day course of antibiotic treatment. The results the Cold-agglutinin titer and thermal amplitude test were suggestive of an IgM warm autoantibody and a cold agglutinin of a moderate titer. The results exclude a diagnosis of cold agglutinin syndrome.

Conclusion
Mycoplasma pneumonia is mainly associated with cold agglutinin syndrome but it is very rare to be associated with WAIHA. WAIHA with a DAT positive for C3 only is relatively rare with an incidence ranging between 6% and 13% and can have a clinical picture ranging from mild to severe anemia. Severe symptomatic hemolysis can be treated with Rituximab, cytotoxic agents or plasmapheresis.
A Case of Recurrent Acute Pain Transfusion Reactions Due to Platelet Transfusion
Authors: Robertson-Patera J , Lu W 
Published: October 2020

Abstract

Introduction/Objective
Transfusion of blood components is one of the most common medical procedures with transfusion reactions being the greatest associated risk. Acute pain transfusion reaction (APTR) is one such under- recognized and under-reported risk, likely due to scarcity of literature and lack of criteria for diagnosis.

Methods
A literature review was performed using PubMed to search for the keywords: “acute pain transfusion reaction”. This searched revealed two articles, from which one abstract and a book chapter were also identified.

Results
A 58-year-old female with chronic myeloid leukemia and pre-existing pain received 44 leukoreduced irradiated blood components [7 pooled platelets, 17 apheresis platelets, 20 red blood cells (RBCs)] over two months. Four platelet (one pooled, three apheresis) transfusions resulted in chest and lower back pain starting an average of 15 minutes after initiation of transfusion and resolving following cessation of transfusion. Laboratory evaluations were negative for hemolysis. Despite the patient’s history of pain, these reactions were most consistent with APTRs.
APTRs are rare, most often associated with leukoreduced RBCs and characterized by severe pain in the abdomen, back, flank, or proximal extremities typically occurring within 30 minutes of starting transfusion and abating within 30 minutes following cessation of transfusion. All of our patient’s reported reactions occurred in association with leukoreduced platelets. These reactions may be associated with the leukoreduction, but reports of APTR appeared when leukoreduction became standard practice. Therefore, the etiology remains unknown.

Conclusion
This case aids in the argument that APTR is a complication of transfusion, despite the absence of a clear etiology or diagnostic criteria. Additional research and improved surveillance are necessary to elucidate potential etiology and improve patient care by identifying prevention and treatment options. A diagnostic criterion would aid efforts to harmonize reporting in the United States and collect the hemovigilance data required to improve transfusion outcomes.
Parental Socioeconomic Status and Autism Spectrum Disorder in Offspring: A Population-Based Cohort Study in Taiwan
Authors: Yu Tsung , Lien Yueh-Ju , Liang Fu-Wen , Kuo Pao-Lin 
Published: October 2020

AbstractStudies from the United States have shown increasing incidence of autism spectrum disorder (ASD) with increasing socioeconomic status (SES), whereas in Scandinavian countries, no such relation was identified. We investigated how ASD risk in offspring varied according to parental SES in Taiwan, where there is universal health care. Through linking birth reporting data and data from Taiwan’s national health insurance program, we studied 706,111 singleton births from 2004 to 2007 and followed them until 2015. Parental SES was determined by monthly salary at the time of childbirth, and child neuropsychiatric outcomes were defined using International Classification of Diseases codes. We identified 7,323 ASD cases and 7,438 intellectual disability (ID) cases; 17% of ASD cases had co-occurring ID. In multivariable Cox regression analysis, higher SES was independently associated with higher risk of ASD after we took into account urbanization levels, child sex, parental age, and other covariates. By contrast, higher SES was independently associated with lower risk of ID. Besides the SES disparity in ASD case ascertainment and in the access to health care, findings from Taiwan suggest that other social, environmental, biological, and immunological factors linked with parental SES levels may contribute to the positive relation of SES and ASD risk.
A genome-wide association study to identify candidate genes for erectile dysfunction
Authors: Kazemi Elham , Zargooshi Javaad , Kaboudi Marzieh , Heidari Parviz , Kahrizi Danial , Mahaki Behzad , Mohammadian Youkhabeh , Khazaei Habibolah , Ahmed Kawsar 
Published: October 2020

AbstractErectile dysfunction (ED) can be caused by different diseases and controlled by several genetic networks. In this study, to identify the genes related to ED, the expression profiles of normal and ED samples were investigated by the Gene Expression Omnibus (GEO) database. Seventeen genes were identified as associated genes with ED. The protein and nucleic acid sequences of selected genes were retrieved from the UCSC database. Selected genes were diverse according to their physicochemical properties and functions. Category function revealed that selected genes are involved in pathways related to humans some diseases. Furthermore, based on protein interactions, genes associated with the insulin pathway had the greatest interaction with the studied genes. To identify the common cis-regulatory elements, the promoter site of the selected genes was retrieved from the UCSC database. The Gapped Local Alignment of Motifs tool was used for finding common conserved motifs into the promoter site of selected genes. Besides, INSR protein as an insulin receptor precursor showed a high potential site for posttranslation modifications, including phosphorylation and N-glycosylation. Also, in this study, two Guanine-Cytosine (GC)-rich regions were identified as conserved motifs in the upstream of studied genes which can be involved in regulating the expression of genes associated with ED. Also, the conserved binding site of miR-29-3p that is involved in various cancers was observed in the 3′ untranslated region of genes associated with ED. Our study introduced new genes associated with ED, which can be good candidates for further analyzing related to human ED.
The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan
Authors: Vidal-Piñeiro Didac , Sneve Markus H , Amlien Inge K , Grydeland Håkon , Mowinckel Athanasia M , Roe James M , Sørensen Øystein , Nyberg Lars H , Walhovd Kristine B , Fjell Anders M 
Published: October 2020

AbstractIt has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6–82 years) whether the functional foundations of successful episodic memory encoding adhere to a principle of lifespan continuity, shaped by developmental, structural, and evolutionary influences. We clustered regions of the cerebral cortex according to the shape of the lifespan trajectory of memory activity in each region so that regions showing the same pattern were clustered together. The results revealed that lifespan trajectories of memory encoding function showed a continuity through life but no evidence of age-specific mechanisms such as compensatory patterns. Encoding activity was related to general cognitive abilities and variations of grey matter as captured by a multi-modal independent component analysis, variables reflecting core aspects of cognitive and structural change throughout the lifespan. Furthermore, memory encoding activity aligned to fundamental aspects of brain organization, such as large-scale connectivity and evolutionary cortical expansion gradients. Altogether, we provide novel support for a perspective on memory aging in which maintenance and decay of episodic memory in older age needs to be understood from a comprehensive life-long perspective rather than as a late-life phenomenon only.
Determination of PAH Benzo[a]anthracene, Chrysene, Benzo[b]flouranthene and Benzo[a]pyrene in Hydro Alcoholic Herbal Extracts with Fluorescence Detector Using Solid-Phase Extraction
Authors: Benny Antony Merina , Benny Antony , Aravind E S 
Published: October 2020

Abstract
An appropriate purification and quantification method has been developed for polycyclic aromatic hydrocarbons (PAH) in hydro alcoholic herbal extracts. For this, Bacopa monnieri, Camellia sinensis, Withania somnifera and Andrographis paniculata samples were extracted with modified solid-phase extraction (SPE) and the PAH were quantified using liquid chromatography coupled to fluorescence detector. Purification of herbal extract using hexane and acetone in the ratio of 1:1 followed by treatment with QuEChERS salt (6 g MgSO4 and 1.5 g sodium acetate) improved the recovery rate of PAH. Silica SPE, which accomplishes solvent exchange to hexane by cleanup method, was developed to reduce the matrix effect and quality of the result obtained was increased. The developed method can be used for regular monitoring and analysis of PAH in natural extracts so as to prevent contamination.
Hurricane effects on climate-adaptive silviculture treatments to longleaf pine woodland in southwestern Georgia, USA
Authors: Bigelow Seth W , Looney Christopher E , Cannon Jeffery B 
Published: October 2020

Abstract
The Adaptive Silviculture for Climate Change (ASCC) network tests silvicultural treatments to promote ‘resistance’ or ‘resilience’ to climate change or speed ‘transition’ to new forest types. Based on projected increases in air temperatures and within-season dry periods in southeastern USA, we installed resistance, resilience and transition treatments involving species selection and varied intensities of density reduction, plus an untreated control, in mixed longleaf pine-hardwood woodland in southwest Georgia USA. Within a year of treatment a tropical cyclone, Hurricane Michael, exposed the site to the unforeseen climatic stress of &gt;44-m s−1 winds. We measured inventory plots post-cyclone and compared the data to pre-storm and pre-treatment values. We analysed stand density index (metric SDI, species maximum value = 1000), stand complexity index (SCI), composition and individual tree characteristics. The ASCC treatments decreased both SDI (from 220 to 124 in the transition treatment) and SCI. The cyclone did not greatly decrease SDI (mean decrease 4.5 per cent) and decreased SCI only in the Controls. Xeric hardwoods were more prone to damage than other functional groups, and ordination showed that the cyclone shifted species composition to greater longleaf pine dominance. Taller trees were more likely to be damaged, except in the resilience treatment, which had a relatively large representation of shorter, more easily damaged xeric hardwoods. The open canopy of the longleaf-hardwood woodland, only 22 per cent of maximum SDI before treatment, evidently fostered wind-firmness, thereby limiting the destructive effect of the cyclone. The sensitivity of xeric hardwoods to hurricane damage suggests that there may be a trade-off between wind tolerance and drought tolerance among functional groups. Maintaining a mixture of drought and wind-resistant species, as in the resilience treatments, may provide broader insurance against multiple climate change impacts in longleaf pine and other forested systems dominated by a single foundation species.
The common EU approach to personal data and cybersecurity regulation
Authors: Mantelero Alessandro , Vaciago Giuseppe , Samantha Esposito Maria , Monte Nicole 
Published: October 2020

Abstract
Several sector-specific studies on EU data protection and cybersecurity frameworks can be found in the literature, but their differing legal domains has hindered the development of a common analysis of the different sets of provisions from a business perspective. This article sets out to bridge this gap, providing a systematic review and a cross-cutting operational analysis of the main legal instruments that constitute the common European approach to personal data and cybersecurity regulation for the business sector. We aim to demonstrate the existence of a core of common principles and procedural approaches referring to specific cybersecurity and data security technologies. Analysis reveals a coordinated regulatory model based on five pillars: risk-based approach, by-design approach, reporting obligations, resilience and certification schemes. We also highlight the relationship between the main directives and regulations.
A Multiancestry Sex-Stratified Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus
Authors: Vergara Candelaria , Valencia Ana , Thio Chloe L , Goedert James J , Mangia Alessandra , Piazzolla Valeria , Johnson Eric , Kral Alex H , O’Brien Thomas R , Mehta Shruti H , Kirk Gregory D , Kim Arthur Y , Lauer Georg M , Chung Raymond T , Cox Andrea L , Peters Marion G , Khakoo Salim I , Alric Laurent , Cramp Matthew E , Donfield Sharyne M , Edlin Brian R , Busch Michael P , Alexander Graeme , Rosen Hugo R , Murphy Edward L , Wojcik Genevieve L , Taub Margaret A , Thomas David L , Duggal Priya 
Published: October 2020

Abstract

Background
Spontaneous clearance of acute hepatitis C virus (HCV) infection is more common in women than in men, independent of known risk factors.

Methods
To identify sex-specific genetic loci, we studied 4423 HCV-infected individuals (2903 male, 1520 female) of European, African, and Hispanic ancestry. We performed autosomal, and X chromosome sex-stratified and combined association analyses in each ancestry group.

Results
A male-specific region near the adenosine diphosphate–ribosylation factor–like 5B (ARL5B) gene was identified. Individuals with the C allele of rs76398191 were about 30% more likely to have chronic HCV infection than individuals with the T allele (OR, 0.69; P = 1.98 × 10−07), and this was not seen in females. The ARL5B gene encodes an interferon-stimulated gene that inhibits immune response to double-stranded RNA viruses. We also identified suggestive associations near septin 6 and ribosomal protein L39 genes on the X chromosome. In box sexes, allele G of rs12852885 was associated with a 40% increase in HCV clearance compared with the A allele (OR, 1.4; P = 2.46 × 10−06). Septin 6 facilitates HCV replication via interaction with the HCV NS5b protein, and ribosomal protein L39 acts as an HCV core interactor.

Conclusions
These novel gene associations support differential mechanisms of HCV clearance between the sexes and provide biological targets for treatment or vaccine development.
On the Effect of Age on the Transmission of SARS-CoV-2 in Households, Schools, and the Community
Authors: Goldstein Edward , Lipsitch Marc , Cevik Muge 
Published: October 2020

Abstract

Background
There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings.

Methods
We reviewed published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, serological studies, and studies of infections in schools.

Results
Compared to younger/middle-aged adults, susceptibility to infection for children younger than 10 years is estimated to be significantly lower, while estimated susceptibility to infection in adults older than 60 years is higher. Serological studies suggest that younger adults (particularly those younger than 35 years) often have high cumulative incidence of SARS-CoV-2 infection in the community. There is some evidence that given limited control measures, SARS-CoV-2 may spread robustly in secondary/high schools, and to a lesser degree in primary schools, with class size possibly affecting that spread. There is also evidence of more limited spread in schools when some mitigation measures are implemented. Several potential biases that may affect these studies are discussed.

Conclusions
Mitigation measures should be implemented when opening schools, particularly secondary/high schools. Efforts should be undertaken to diminish mixing in younger adults, particularly individuals aged 18–35 years, to mitigate the spread of the epidemic in the community.
Racial Capitalism, Islamophobia, and Austerity
Authors: Ali Nadya , Whitham Ben 
Published: October 2020

AbstractExplorations of Islamophobia or anti-Muslim racism predominantly focus on issues of security policy and media representations, set against the backdrop of the global “War on Terror.” This scholarship explores the racialization of Muslim populations across different global contexts, including the UK, Europe, the United States, and China. However, Islamophobia has also been articulated through concerns about the economy, jobs, public services, and national debt in times of austerity. Narratives have emerged around Muslim families in the UK receiving “excessive” welfare benefits, preferential access to social housing, and pressuring public services through “breeding.” This article offers a new way of thinking about the links between Islamophobia and austerity through an engagement with the literature on racial capitalism. The article shows how constructions of Muslim populations as the “undeserving poor” are central to the intersectional racialized and gendered disentitlements of austerity. The analysis draws on the findings from twelve interviews and a six-person focus group with Muslim subjects based in London to illustrate the political economy of austerity Islamophobia.
Intrapuparial Age Estimation of Forensically Important Dohrniphora cornuta (Diptera: Phoridae)
Authors: Feng Dian-Xing , Wu Jing , Sun Da-Peng 
Published: October 2020

Abstract
Dohrniphora cornuta (Bigot) is a forensically important phorid fly indoors and in burial environments. The determination of a minimum postmortem interval (PMImin) often relies on the determination of the age of the immatures. Although the larval development data of D. cornuta under different temperatures has been established, the intrapuparial stage which lasts for about half of the total immature development is scarce. In this study, we investigated the key morphological changes during intrapuparial development at constant temperatures (15, 18, 21, 24, 27, 30, 33, and 36°C), with an aim to estimate the intrapuparial age of D. cornuta. Puparia were sampled at 12-h (24, 27, 30, and 33°C), 24-h (18 and 21°C), and 48-h (15°C) intervals. The morphological developments within the puparium were analyzed using a stereomicroscope after the puparium was removed. The average minimum duration of intrapuparial stage was inversely related to temperature, ranging from 184.79 ± 3.00 h at 30°C to 1102.86 ± 25.55 h at 15°C for female, and 197.40 ± 4.12 h at 30°C to 1175.33 ± 18.55 h at 15°C for male. It did not develop at 36°C. Some morphological traits that changed during development within the puparium could be used as age markers. According to these changes, the intrapuparial stage of D. cornuta was divided into nine stages which could be used for both sexes. This study provides relatively systematic development data of D. cornuta intrapuparial for the estimation of PMImin in forensic entomology.
Toxic Effects of Fine Plant Powder Impregnated With Avermectins on Mosquito Larvae and Nontarget Aquatic Invertebrates
Authors: Belevich Olga , Yurchenko Yury , Alekseev Alexander , Kotina Oxana , Odeyanko Vyacheslav , Tsentalovich Yury , Yanshole Lyudmila , Kryukov Vadim , Danilov Victor , Glupov Victor 
Published: October 2020

Abstract
The toxic effects of an avermectin-impregnated fine plant powder (AIFP) against larval Aedes aegypti L. (Diptera: Culicidae), Culex modestus Ficalbi (Diptera: Culicidae), and Anopheles messeae Falleroni (Diptera: Culicidae), as well as selected nontarget aquatic invertebrates, were studied under laboratory conditions. The possibility of trophic transfer of avermectins (AVMs) through the food chain and their toxic effects on predaceous species fed AIFP-treated mosquito larvae was also evaluated. Among mosquitoes, Anopheles messeae were the most sensitive to AIFP, while Cx. modestus exhibited the least sensitivity to this formulation. Among nontarget aquatic invertebrates, the greatest toxicity of AIFP was observed for benthic species (larval Chironomus sp. Meigen (Diptera: Chironomidae), whereas predators (dragonflies, water beetles, and water bugs) exhibited the lowest AIFP sensitivity. AIFP sensitivity of the clam shrimp Lynceus brachyurus O. F. Muller (Diplostraca: Lynceidae), the phantom midge Chaoborus crystallinus De Geer (Diptera: Chaoboridae), and the mayfly Caenis robusta Eaton (Ephemeroptera: Caenidae) was intermediate and similar to the sensitivity of the mosquito Cx. modestus. However, these nontarget species were more resistant than An. messeae and Ae. aegypti. Solid-phase extraction of mosquito larvae treated with AIFP and subsequent high-performance liquid chromatography (HPLC) analysis of the extracts revealed an AVM concentration of up to 2.1 ± 0.3 μg/g. Feeding the creeping water bug Ilyocoris cimicoides L. (Hemiptera: Naucoridae) on the AIFP-treated mosquito larvae resulted in 51% mortality of the predaceous species. But no toxicity was observed for Aeshna mixta Latreille (Odonata: Aeshnidae) dragonfly larvae fed those mosquito larvae. The results of this work showed that this AVM formulation can be effective against mosquito larvae.