bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Targets of Actein Identified by Systems Chemical Biology Methods
Authors: Liao Xuan , Zhang Qing‐Ye , Xu Lei , Zhang Hong‐Yu 
Published: December 2019

AbstractActein is the main active ingredient of medicinal plant Cimicifuga racemosa (L.) Nutt, which has been reported to have various pharmacological effects, but the mechanism of actein remains undetermined. In this study, systems chemical biology methods were used to predict the targets and elucidate the pharmacological mechanisms of actein. First, 54 gene co‐expression modules were obtained by biclustering. Then, the top 1 % agents with the highest regulatory similarity were screened out to be highly functionally similar to actein. Finally, the results of molecular docking and molecular dynamics simulation showed that actein has a stronger interaction with eight targets than original ligands. It suggests that the antipsychotic effect of actein probably occurs by targeting the key residues of the eight receptors, which are compatible with previously reported information. This study not only provides predicted targets of actein, but also a new method for exploring the mechanisms of other natural products in drug discovery.
E‐Bayesian and hierarchical Bayesian estimations for parallel system model in the presence of masked data
Authors: Cai Jing , Shi Yimin , Lin Ting 
Published: December 2019

SummaryIn this paper, we consider the statistical analysis of parallel system with inverse Weibull distributed components. Due to cost and time constraints, the causes of system failures are masked and the type‐II censored observations might occur in the collected data. Under the symmetric and asymmetric loss functions, the expected Bayesian (E‐Bayesian) method and the hierarchical Bayesian method are proposed to estimate the parameters, as well as the reliability function. Numerical simulations using the Monte Carlo (MC) method are given to demonstrate the performances of the estimations under different masking levels and effective sample sizes. Finally, one data set is analyzed for illustrative purpose.
Robust congestion control in cognitive radio network using dynamic event‐triggered sliding mode
Authors: Majumder Tirtha , Mishra Rajiv Kumar , Sinha Abhinav , Singh Sudhansu Sekhar , Kumar Sahu Prasanna 
Published: December 2019

SummaryThe ever‐increasing service demand from wireless users under restricted bandwidth necessitates the development of suitable congestion control scheme for throughput maximization. A robust congestion controller design has been addressed in this work to sustain necessary Quality of Service in Cognitive Radio Network. The goal is to reduce packet loss while ensuring optimum utilization of available resources. Sliding mode controller proclaimed for its disturbance rejection capabilities and robustness has been used to design the proposed controller. Using the benefits of sliding mode control, dynamic event‐triggering strategies have been combined for better utilization in resource‐constrained environments. Control execution requires minimal updates while guaranteeing the desired closed‐loop system behavior. The controller efficacy has been validated in simulations.
Metabolism of a new synthetic opioid tetrahydrofuranylfentanyl in fresh isolated human hepatocytes: Detection and confirmation of ring‐opened metabolites
Authors: Kanamori Tatsuyuki , Segawa Hiroki , Yamamuro Tadashi , Kuwayama Kenji , Tsujikawa Kenji , Iwata Yuko T. 
Published: December 2019

AbstractThe metabolism of a new synthetic opioid tetrahydrofuranylfentanyl (THF‐fentanyl) was investigated using fresh human hepatocytes. Fourteen metabolites of THF‐fentanyl, such as tetrahydrofuran ring‐opened metabolites, desphenethylated metabolites, hydroxylated metabolites, and hydroxylated and methoxylated metabolites and their glucuronides, were detected in the culture medium of hepatocytes incubated with THF‐fentanyl. Six metabolites, i.e. desphenethylated metabolite, 4′‐hydroxy‐THF‐fentanyl, β‐hydroxy‐THF‐fentanyl, 4′‐hydroxy‐3′‐methoxy‐THF‐fentanyl, ring‐opened alcohol metabolite, and ring‐opened carboxylic acid metabolite, were identified via chemically synthesized authentic standards. A ring‐opened alcohol metabolite and a ring‐opened carboxylic acid metabolite are thought to be formed by reduction or oxidation of the intermediate aldehyde, which was formed by ring‐opening of the metabolite hydroxylated at the carbon atom adjacent to the oxygen atom of the tetrahydrofuran ring. A ring‐opened carboxylic acid metabolite was the main metabolite of THF‐fentanyl based on the peak intensity.
Comparison of feature tracking, fast‐SENC, and myocardial tagging for global and segmental left ventricular strain
Authors: Bucius Paulius , Erley Jennifer , Tanacli Radu , Zieschang Victoria , Giusca Sorin , Korosoglou Grigorious , Steen Henning , Stehning Christian , Pieske Burkert , Pieske‐Kraigher Elisabeth , Schuster Andreas , Lapinskas Tomas , Kelle Sebastian 
Published: December 2019

AbstractAimsA multitude of cardiac magnetic resonance (CMR) techniques are used for myocardial strain assessment; however, studies comparing them are limited. We sought to compare global longitudinal (GLS), circumferential (GCS), segmental longitudinal (SLS), and segmental circumferential (SCS) strain values, as well as reproducibility between CMR feature tracking (FT), tagging (TAG), and fast‐strain‐encoded (fast‐SENC) CMR techniques.Methods and resultsEighteen subjects (11 healthy volunteers and seven patients with heart failure) underwent two CMR scans (1.5T, Philips) with identical parameters. Global and segmental strain values were measured using FT (Medis), TAG (Medviso), and fast‐SENC (Myocardial Solutions). Friedman's test, linear regression, Pearson's correlation coefficient, and Bland–Altman analyses were used to assess differences and correlation in measured GLS and GCS between the techniques. Two‐way mixed intra‐class correlation coefficient (ICC), coefficient of variance (COV), and Bland–Altman analysis were used for reproducibility assessment.All techniques correlated closely for GLS (Pearson's r: 0.86–0.92) and GCS (Pearson's r: 0.85–0.94). Intra‐observer and inter‐observer reproducibility was excellent in all techniques for both GLS (ICC 0.92–0.99, CoV 2.6–10.1%) and GCS (ICC 0.89–0.99, CoV 4.3–10.1%). Inter‐study reproducibility was similar for all techniques for GLS (ICC 0.91–0.96, CoV 9.1–10.8%) and GCS (ICC 0.95–0.97, CoV 7.6–10.4%). Combined segmental intra‐observer reproducibility was good in all techniques for SLS (ICC 0.914–0.953, CoV 12.35–24.73%) and SCS (ICC 0.885–0.978, CoV 10.76–19.66%). Combined inter‐study SLS reproducibility was the worst in FT (ICC 0.329, CoV 42.99%), while fast‐SENC performed the best (ICC 0.844, CoV 21.92%). TAG had the best reproducibility for combined inter‐study SCS (ICC 0.902, CoV 19.08%), while FT performed the worst (ICC 0.766, CoV 32.35%). Bland–Altman analysis revealed considerable inter‐technique biases for GLS (FT vs. fast‐SENC 3.71%; FT vs. TAG 8.35%; and TAG vs. fast‐SENC 4.54%) and GCS (FT vs. fast‐SENC 2.15%; FT vs. TAG 6.92%; and TAG vs. fast‐SENC 2.15%). Limits of agreement for GLS ranged from ±3.1 (TAG vs. fast‐SENC) to ±4.85 (FT vs. TAG) for GLS and ±2.98 (TAG vs. fast‐SENC) to ±5.85 (FT vs. TAG) for GCS.ConclusionsWe found significant differences in measured GLS and GCS between FT, TAG, and fast‐SENC. Global strain reproducibility was excellent for all techniques. Acquisition‐based techniques had better reproducibility than FT for segmental strain.
Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease
Authors: Katsouri Loukia , Birch Amy M. , Renziehausen Alexander W. J. , Zach Carolin , Aman Yahyah , Steeds Hannah , Bonsu Angela , Palmer Emily O. C. , Mirzaei Nazanin , Ries Miriam , Sastre Magdalena 
Published: December 2019

AbstractThe role of astrocytes in the progression of Alzheimer's disease (AD) remains poorly understood. We assessed the consequences of ablating astrocytic proliferation in 9 months old double transgenic APP23/GFAP‐TK mice. Treatment of these mice with the antiviral agent ganciclovir conditionally ablates proliferating reactive astrocytes. The loss of proliferating astrocytes resulted in significantly increased levels of monomeric amyloid‐β (Aβ) in brain homogenates, associated with reduced enzymatic degradation and clearance mechanisms. In addition, our data revealed exacerbated memory deficits in mice lacking proliferating astrocytes concomitant with decreased levels of synaptic markers and higher expression of pro‐inflammatory cytokines. Our data suggest that loss of reactive astrocytes in AD aggravates amyloid pathology and memory loss, possibly via disruption of amyloid clearance and enhanced neuroinflammation.
Induction chemotherapy followed by radiotherapy for N3 head and neck squamous cell carcinoma
Authors: Du Chengrun , Blanchard Pierre , Even Caroline , Boros Angela , Gorphe Philippe , Breuskin Ingrid , Baste‐Rotllan Neus , Nguyen France , Ruffier Amandine , Bidault François , Billard Camélia , Janot François , Mirghani Haitham , Temam Stephane , Tao Yungan 
Published: December 2019

AbstractBackgroundThe treatment outcomes for N3 HNSCC treated with induction chemotherapy (ICT) followed by definitive radiation were reported to clarify the role of ICT and potential prognostic factors.MethodsA retrospective study was conducted on 120 patients with N3 (≥6 cm) HNSCC, who were treated with ICT as initial treatment. Survival outcomes and potential prognostic factors were reported.ResultsThe response rate to ICT was 68.3%. There was a statistically significant difference between responders and non‐responders in terms of 5‐year OS (35.1% vs 13.3%, P < .001) and PFS (29.4% vs 7.4%, P < .001). Good response to ICT (P < .001) and upfront neck dissection (UFND) before radiotherapy (P = .016) were factors predicting for better OS. However, UFND before radiotherapy was not associated with improved outcomes among responders.ConclusionsThis study suggests that ICT could be one treatment option for N3 HNSCC. Among responders to ICT, UFND before radiotherapy could be avoided.
Estimation of Differential Code Bias of IRNSS Satellites using Global Ionosphere Map
Authors: Lingwal Yogesh , Kumar Rajesh , Singh F. B. , Ramakrishna B.N. 
Published: December 2019

AbstractIRNSS (Indian Regional Navigation Satellite System) is an independent satellite based regional navigation system, developed by India, with an aim to provide accurate positioning and timing services to user in India as well as 1500 km away from its boundary. IRNSS is a constellation of seven satellites, three satellites are orbiting in a GEO (Geostationary orbit) and remaining four satellites are in GSO (Geosynchronous orbit).IRNSS provides navigation services on two frequencies i.e. L5 (1176.45 ± 12 MHz) and S band (2492.028 ± 8.25 MHz). The measurements from dual frequency IRNSS/NavIC (Navigation with Indian Constellation) receiver are affected by instrument bias of satellite and receiver. Differential Code Bias (DCB) is the hardware bias between two GNSS code at same or different frequency. DCB can't be ignored for both precise positioning as well as for precise TEC estimation. Currently there are limited numbers of IRNSS satellites, so it is difficult to build an independent Ionospheric model for the precise estimation of DCB of IRNSS satellites.There are several Ionospheric Associated Analysis centers (IAAC), providing the DCB (Differential Code Bias) of different GNSS satellites (GPS, GLONASS etc.) along with the Global Ionospheric Map (GIM) on routine basis. Knowledge of DCB is currently unavailable for newly developed constellations like IRNSS, due to the limited number of satellites and monitoring stations. In this paper Global Ionospheric Map (GIM) published by IGS (International GNSS services) is used as a reference for the estimation of DCB of IRNSS satellites. More than 60 days' observation data of IRNSS Range integrity and monitoring station (IRIMS) were analysed and DCB of each day was computed with the stability of up‐to ∼1 ns for all IRNSS satellites in constellation.
Characterizing and decomposing classes of threshold, split, and bipartite graphs via 1‐Sperner hypergraphs
Authors: Boros Endre , Gurvich Vladimir , Milanič Martin 
Published: December 2019

AbstractA hypergraph is said to be 1‐Sperner if for every two hyperedges the smallest of their two set differences is of size one. We present several applications of ‐Sperner hypergraphs to graphs. First, we consider several ways of associating hypergraphs to graphs, namely, vertex cover, clique, independent set, dominating set, and closed neighborhood hypergraphs. For each of them, we characterize graphs yielding ‐Sperner hypergraphs. These results give new characterizations of threshold and domishold graphs. Second, we apply a characterization of ‐Sperner hypergraphs to derive decomposition theorems for two classes of split graphs, a class of bipartite graphs, and a class of cobipartite graphs. These decomposition theorems, based on certain matrix partitions, lead to new classes of graphs of bounded clique‐width and new polynomially solvable cases of three basic domination problems: domination, total domination, and connected domination.
Effect of Liraglutide on Cardiovascular Function and Myocardial Tissue Characteristics in Type 2 Diabetes Patients of South Asian Descent Living in the Netherlands: A Double‐Blind, Randomized, Placebo‐Controlled Trial
Authors: Paiman Elisabeth H.M. , van Eyk Huub J. , van Aalst Minke M.A. , Bizino Maurice B. , van der Geest Rob J. , Westenberg Jos J.M. , Geelhoed‐Duijvestijn Petronella H. , Kharagjitsingh Aan V. , Rensen Patrick C.N. , Smit Johannes W.A. , Jazet Ingrid M. , Lamb Hildo J. 
Published: December 2019

BackgroundThe glucagon‐like peptide‐1 (GLP‐1) receptor agonist liraglutide may be beneficial in the regression of diabetic cardiomyopathy. South Asian ethnic groups in particular are at risk of developing type 2 diabetes.PurposeTo assess the effects of liraglutide on left ventricular (LV) diastolic and systolic function in South Asian type 2 diabetes patients.Study TypeProspective, double‐blind, randomized, placebo‐controlled trial.PopulationForty‐seven type 2 diabetes patients of South Asian ancestry living in the Netherlands, with or without ischemic heart disease, who were randomly assigned to 26‐week treatment with liraglutide (1.8 mg/day) or placebo.Field Strength/Sequence3T (balanced steady‐state free precession cine MRI, 2D and 4D velocity‐encoded MRI, 1H‐MRS, T1 mapping).AssessmentPrimary endpoints were changes in LV diastolic function (early deceleration peak [Edec], ratio of early and late peak filling rate [E/A], estimated LV filling pressure [E/Ea]) and LV systolic function (ejection fraction). Secondary endpoints were changes in aortic stiffness (aortic pulse wave velocity [PWV]), myocardial steatosis (myocardial triglyceride content), and diffuse fibrosis (extracellular volume [ECV]).Statistical TestsData were analyzed according to intention‐to‐treat. Between‐group differences were reported as mean (95% confidence interval [CI]) and were assessed using analysis of covariance (ANCOVA).ResultsLiraglutide (n = 22) compared with placebo (n = 25) did not change Edec (+0.2 mL/s2 × 10‐3 (–0.3;0.6)), E/A (–0.09 (–0.23;0.05)), E/Ea (+0.1 (–1.2;1.3)) and ejection fraction (0% (–3;2)), but decreased stroke volume (–9 mL (–14;–5)) and increased heart rate (+10 bpm (4;15)). Aortic PWV (+0.5 m/s (–0.6;1.6)), myocardial triglyceride content (+0.21% (–0.09;0.51)), and ECV (–0.2% (–1.4;1.0)) were unaltered.Data ConclusionLiraglutide did not affect LV diastolic and systolic function, aortic stiffness, myocardial triglyceride content, or extracellular volume in Dutch South Asian type 2 diabetes patients with or without coronary artery disease.Level of Evidence: 1Technical Efficacy Stage: 4J. Magn. Reson. Imaging 2020;51:1679–1688.
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury
Authors: Yarrow Joshua F. , Kok Hui Jean , Phillips Ean G. , Conover Christine F. , Lee Jimmy , Bassett Taylor E. , Buckley Kinley H. , Reynolds Michael C. , Wnek Russell D. , Otzel Dana M. , Chen Cong , Jiron Jessica M. , Graham Zachary A. , Cardozo Christopher , Vandenborne Krista , Bose Prodip K. , Aguirre Jose Ignacio , Borst Stephen E. , Ye Fan 
Published: December 2019

AbstractLoading and testosterone may influence musculoskeletal recovery after spinal cord injury (SCI). Our objectives were to determine (a) the acute effects of bodyweight‐supported treadmill training (TM) on hindlimb cancellous bone microstructure and muscle mass in adult rats after severe contusion SCI and (b) whether longer‐term TM with adjuvant testosterone enanthate (TE) delivers musculoskeletal benefit. In Study 1, TM (40 min/day, 5 days/week, beginning 1 week postsurgery) did not prevent SCI‐induced hindlimb cancellous bone loss after 3 weeks. In Study 2, TM did not attenuate SCI‐induced plantar flexor muscles atrophy nor improve locomotor recovery after 4 weeks. In our main study, SCI produced extensive distal femur and proximal tibia cancellous bone deficits, a deleterious slow‐to‐fast fiber‐type transition in soleus, lower muscle fiber cross‐sectional area (fCSA), impaired muscle force production, and levator ani/bulbocavernosus (LABC) muscle atrophy after 8 weeks. TE alone (7.0 mg/week) suppressed bone resorption, attenuated cancellous bone loss, constrained the soleus fiber‐type transition, and prevented LABC atrophy. In comparison, TE+TM concomitantly suppressed bone resorption and stimulated bone formation after SCI, produced near‐complete cancellous bone preservation, prevented the soleus fiber‐type transition, attenuated soleus fCSA atrophy, maintained soleus force production, and increased LABC mass. 75% of SCI+TE+TM animals recovered voluntary over‐ground hindlimb stepping, while no SCI and only 20% of SCI+TE animals regained stepping ability. Positive associations between testosterone and locomotor function suggest that TE influenced locomotor recovery. In conclusion, short‐term TM alone did not improve bone, muscle, or locomotor recovery in adult rats after severe SCI, while longer‐term TE+TM provided more comprehensive musculoskeletal benefit than TE alone.
What proportion of unplanned re‐presentations to an emergency department are medication related and preventable?
Authors: Whitaker Ann S. , Cottrell W. Neil 
Published: December 2019

AbstractBackgroundAustralian data suggest that one‐fifth of emergency department (ED) presentations are re‐presentations within 28 days of discharge, with early re‐presentations common. The contribution of medication misadventure to re‐presentations has been poorly defined to date, but has been reported previously as medication‐related readmission rates of 23%, of which 90% are considered preventable.AimsThis study identified and categorised medication‐related 28‐day ED re‐presentations after discharge, associated medication‐related problems (MRPs) and differences in demographics between medication‐related and ‐unrelated ED re‐presentations.MethodsA retrospective medical record review was conducted for every third adult 28‐day ED re‐presentation between 1 July and 31 December 2016. Re‐presentations were examined for potential medication‐related causes. The MRPs identified were categorised using causality, contribution and preventability criteria.ResultsOf 631 eligible re‐presentations, 196 were sampled. Re‐presentations were potentially medication related in 41 (21%) cases; in 24 (59%) re‐presentations, preventable MRPs were considered the main cause of re‐presentation. Early medication‐related re‐presentations were common: 49% occurred within 7 days of discharge, and 20% on Day 1. Patients re‐presenting with an MRP were, on average, 10.3 years older and prescribed 3.4 more medications on the index discharge than those re‐presenting with a non‐MRP. Cardiovascular medications (n = 14) were most commonly implicated in MRPs, with toxicity or adverse reaction (n = 16) and undertreated (n = 15) the most common MRP categories.ConclusionsOne‐fifth of the 28‐day ED re‐presentations observed were considered potentially medication related, with 59% of these associated with MRPs considered preventable. MRPs most frequently involved cardiovascular medications, adverse reactions and undertreatment. Early individualised pharmaceutical review after discharge may help reduce the MRPs observed.
A clinical‐radiomic model for improved prognostication of surgical candidates with colorectal liver metastases
Authors: Shur Joshua , Orton Matthew , Connor Ashton , Fischer Sandra , Moulton Carol‐Anne , Gallinger Steven , Koh Dow‐Mu , Jhaveri Kartik S. 
Published: December 2019

AbstractBackground and ObjectivesColorectal cancer with liver metastases is potentially curable with surgical resection however clinical prognostic factors can insufficiently stratify patients. This study aims to assess whether radiomic features are prognostic and can inform clinical decision making.MethodsThis single‐site retrospective study included 102 patients who underwent colorectal liver metastases resection with preoperative computed tomography (CT), magnetic resonance imaging (MRI) with gadoxetic acid (EOB) and clinical covariates. A lasso‐regularized multivariate Cox proportional hazards model was applied to 114 features (10 clinical, 104 radiomic) to determine association with disease‐free survival (DFS). A prognostic index was derived using the significant Cox regression coefficients and their corresponding input features and a threshold was determined to classify patients into high‐ and low‐risk groups, and DFS compared using log‐rank tests.ResultsFour covariates were significantly associated with DFS; bilobar disease (hazard ratio [HR]= 1.56;P = .0043), complete pathological response (HR= 0.67;P = .025), minimum pixel value (HR= 1.66;P = .00016), and small area emphasis (HR= 0.62;P = .0013) from the EOB‐MRI data. Radiomic CT features were not prognostic. The prognostic index strongly stratified high‐ and low‐risk prognostic groups (HR = 0.31;P = .00068).ConclusionRadiomic MRI features provided meaningful prognostic information above clinical covariates alone. This merits further validation for potential clinical implementation to inform management.
Gastric cancer molecular classification and adjuvant therapy: Is there a different benefit according to the subtype?
Authors: Ramos Marcus F. K. P. , Pereira Marina A. , Amorim Larissa C. , de Mello Evandro S. , Faraj Sheila F. , Ribeiro Ulysses , Hoff Paulo M. G. , Cecconello Ivan , de Castria Tiago B. 
Published: December 2019

AbstractBackgroundGastric cancer (GC) has been defined in distinct molecular subtypes with different therapeutic implications. However, its clinical significance and prognosis regarding standard chemotherapy (CMT) remains unclear. This study aimed to analyze the impact of perioperative or adjuvant treatment among subtypes of GC.MethodsWe retrospectively evaluated all stage II/III patients with GC who underwent a curative gastrectomy. Based on immunohistochemistry and in situ hybridization techniques, GC was classified into five subtypes: Epstein‐Barr virus (EBV) positive, microsatellite instability (MSI), e‐cadherin aberrant, p53‐aberrant, and p53‐normal.ResultsAmong the 178 CG included, 111 patients received CMT and 67 were treated with surgery alone. Survival analysis showed that p53‐aberrant GC treated with CMT had better disease‐free survival (DFS) compared with surgery alone (P = .001).There was no significant difference in DFS between patients who received CMT and those with surgery alone for EBV, MSI, E‐cadherin, and p53‐normal GC. An improvement in overall survival was observed only for E‐cadherin (P = .001) and p53‐aberrant (P < .001) patients who received CMT.ConclusionsCMT showed different impact on the survival of CG according to the molecular subtype. No survival benefit was observed for EBV and MSI groups who received CMT. GC with p53‐aberrant had a significant benefit in survival with standard therapy.