bluuebunny/crossref_metadata_2025_split huggingface dataset:
False‐positive electrocardiographic changes during exercise test in a patient with pectus excavatum
Authors: Sonaglioni Andrea , Nicolosi Gian Luigi , Lombardo Michele , Anzà Claudio , Ambrosio Giuseppe 
Published: April 2020

AbstractExercise‐induced ST‐segment changes simulating myocardial ischemia have been described in otherwise normal subjects during hyperventilation. We present the case of a 60‐year‐old man with pectus excavatum showing significant exercise‐induced “pseudo‐ischaemic” ST‐segment changes with neither coronary artery disease nor anxiety‐induced hyperventilation. We found no report of the possible causative role of a narrow antero‐posterior chest diameter in inducing “pseudo‐ischaemic” ST‐segment changes during exercise stress test in the literature.
Dissociative photoionization of 1,3‐dioxolane: We need six channels to fit the elephant
Authors: Weidner Peter , Voronova Krisztina , Bodi Andras , Sztáray Bálint 
Published: April 2020

AbstractThe dissociative photoionization of 1,3‐dioxolane was studied by photoelectron photoion coincidence (PEPICO) spectroscopy in the photon energy range of 9.5–13.5 eV. Our statistical thermodynamics model shows that a total of six dissociation channels are involved in the formation of three fragment ions, namely, C3H5O2+(m/z73), C2H5O+(m/z45), and C2H4O+(m/z44), with two channels contributing to the formation of each. By comparing the results of ab initio quantum chemical calculations to the experimentally derived appearance energies of the fragment ions, the most likely mechanisms for these unimolecular dissociation reactions are proposed, including a description of the relevant parts of the potential energy surface.
Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice
Authors: Annie Lalrawngbawli , Jeremy Malsawmhriatzuala , Gurusubramanian Guruswami , Derkach Kira V. , Shpakov Alexander O. , Roy Vikas Kumar 
Published: April 2020

AbstractDiabetes mellitus impairs testicular activity and leads to infertility. Leptin is one of the endogenous regulators of the male reproductive functions, but the role of leptin and its receptor (LEPR/Ob‐R) in the control of testosterone production and testicular proliferation has not been investigated so far, especially in the Type 1 diabetes mellitus (DM1). Metformin is an anti‐hyperglycemic drug which is beneficial for treating the both DM2 and DM1. The aim of this work was to study the possible role of leptin and Ob‐R in the regulation of steroidogenesis and proliferation in the testes of mice with streptozotocin‐induced DM1 (75 mg/kg/day, 4 days) and to estimate the restoring effect of metformin treatment (500 mg/kg, 2 weeks) on the diabetic testes. In the diabetic testes, the plasma and intratesticular leptin levels and plasma testosterone levels were reduced and completely restored by metformin treatment. Metformin also restored the expression of the steroidogenic transport protein steroidogenic acute regulatory protein reduced in DM1. In the diabetic testes, the expression of Ob‐R was downregulated and the immunolocalization of Ob‐R showed weak staining in the Leydig cells, the primary spermatocytes and the round spermatids. The germ cell proliferation was also reduced in DM1, as noticed with proliferating cell nuclear antigen (PCNA) expression. Metformin increased the Ob‐R expression and immunostaining in the different cell types and improved the PCNA expression. Thus, DM1 impairs the testicular steroidogenesis and proliferation by inhibiting the leptin signaling, causing a decrease in leptin levels and Ob‐R expression in the testes of diabetic mice, while metformin improves the leptin signaling and restores testosterone production and testicular proliferation.
Isotropic 3D Cartesian single breath‐hold CINE MRI with multi‐bin patch‐based low‐rank reconstruction
Authors: Küstner Thomas , Bustin Aurelien , Jaubert Olivier , Hajhosseiny Reza , Masci Pier Giorgio , Neji Radhouene , Botnar René , Prieto Claudia 
Published: April 2020

AbstractPurposeTo develop a novel acquisition and reconstruction framework for isotropic 3D Cartesian cardiac CINE within a single breath‐hold for left ventricle (LV) and whole‐heart coverage.MethodsA variable‐density Cartesian acquisition with spiral profile ordering, out‐inward sampling, and acquisition‐adaptive alternating tiny golden/golden angle increment between spiral arms is proposed to provide incoherent and nonredundant sampling within and among cardiac phases. A novel multi‐bin patch‐based low‐rank reconstruction, named MB‐PROST, is proposed to exploit redundant information on a local (within a patch), nonlocal (similar patches within a spatial neighborhood), and temporal (among all cardiac phases) scale with an implicit motion alignment among patches. The proposed multi‐bin patch‐based low‐rank reconstruction reconstruction is compared against compressed sensing reconstruction, whereas LV function parameters derived from the proposed 3D CINE framework are compared against those estimated from conventional multislice 2D CINE imaging in 10 healthy subjects and 15 patients.ResultsThe proposed framework provides 3D cardiac CINE images with high spatial (1.9 mm3) and temporal resolution (˜50 ms) in a single breath‐hold of ˜20 s for LV and ˜26 s for whole‐heart coverage in healthy subjects. Shorter breath‐hold durations of ˜13 to 15 s are feasible for LV coverage with slightly anisotropic resolution (1.9 × 1.9 × 2.5 mm) in patients. LV function parameters derived from 3D CINE were in good agreement with 2D CINE, with a bias of −0.1 mL/0.1 mL, −0.9 mL/−1.0 mL, −0.1%/−0.8%; and confidence intervals of ±1.7 mL/±3.7 mL, ±1.2 mL/±2.6 mL, and ±1.2%/±3.6% (10 healthy subjects/15 patients) for end‐systolic volume, end‐diastolic volume, and ejection fraction, respectively.ConclusionThe proposed framework enables 3D isotropic cardiac CINE in a single breath‐hold scan of ˜20 s/˜26 s for LV/whole‐heart coverage, showing good agreement with clinical 2D CINE scans in terms of LV functional assessment.
What if artificial urinary sphincter is not possible? Feasibility and effectiveness of ProACT for patients with persistent stress urinary incontinence after radical prostatectomy treated by sling
Authors: Munier Pierre , Nicolas Marc , Tricard Thibault , Droupy Stéphane , Costa Pierre , Saussine Christian 
Published: April 2020

AbstractBackgroundStress urinary incontinence (SUI) is a major component of the post radical prostatectomy (RP) trifecta. Surgical treatments are sub‐urethral slings, artificial urinary sphincter (AUS) and adjustable peri‐urethral balloons (PUB) ProACT. All options are imperfect at best and persistent SUI is challenging when AUS is not manageable.AimsThis study analyzed the cumulate experience of our 2 centers with offering PUB implantation for SUI post RP in patients with insufficient improvement from slings.Materials & MethodsThis retrospective study reviewed all patients implanted with second line ProACT. The primary endpoint was continence, defined as 0 pads per day (PPD). The secondary endpoints were 50% decrease in PPD and increases in the Incontinence Quality of Life score (IQOL). Refilling and complications were reported.ResultsBetween 2007 and 2016, 26 patients were implanted. Five patients have had adjuvant radiotherapy (18%). The mean follow‐up was 36 months (±20; min 14‐max 128). All patient presented with persistent SUI, using 2.3 PPD (±1; min 1–max 6), and only one sling was removed due to infection. After ProACT with an average 3 mL refilling (±1.2 min 2–max 6), 18 patients (66.7%) were continent. Eight of the remaining patients (29.6%) were improved; their number of PPD decreased from 2.6 to 1. The average IQOL score of those 8 patients increased by 20 points, from 53.4 up to 74.2 (P = .005). Overall 26 patients (96.3%) were improved. The remaining patient was not implanted because of an intraoperative urethral injury and is considered a failed case (3.7%). He had instead an AUS implantation. Three patients (14.8%) needed PUB replacement.ConclusionThe limited population of patients from both our centers who presented with persistent SUI after RP, despite sling placement, improved with PUB ProACT implantations without significant complications.
Sheltering under a shield of love—A phenomenological–hermeneutic study of relatives' experiences in an acute neurological ward
Authors: Hesselvig Lærke Toft , Beck Malene , Simony Charlotte 
Published: April 2020

AbstractAimTo investigate the lived experience of being a relative to a patient admitted to an acute neurological ward to bring knowledge of what is essential to them.DesignThe study takes a phenomenological–hermeneutic approach.MethodsData were gathered through six individual semi‐structured interviews with relatives from an acute neurological ward. A three‐levelled analysis and interpretation inspired by Paul Ricoeur's philosophy was applied.ResultsTwo main themes were identified: To make yourself strong while feeling vulnerable inside and To live in a changed everyday life. Within these themes, the connection between the relatives and the patients appeared to be a relationship of love. In this relationship, the relatives experience existential vulnerability. The lives of relatives undergo a difficult upheaval, which is challenged by deep emotional feelings. However, to be able to be there for their loved ones they are sheltering under a shield of love.
Model predictive control of a collaborative manipulator considering dynamic obstacles
Authors: Krämer Maximilian , Rösmann Christoph , Hoffmann Frank , Bertram Torsten 
Published: April 2020

SummaryCollaborative robots have to adapt its motion plan to a dynamic environment and variation of task constraints. Currently, they detect collisions and interrupt or postpone their motion plan to prevent harm to humans or objects. The more advanced strategy proposed in this article uses online trajectory optimization to anticipate potential collisions, task variations, and to adapt the motion plan accordingly. The online trajectory planner pursues a model predictive control approach to account for dynamic motion objectives and constraints during task execution. The prediction model relates reference joint velocities to actual joint positions as an approximation of built‐in robot tracking controllers. The optimal control problem is solved with direct collocation based on a hypergraph structure, which represents the nonlinear program and allows to efficiently adapt to structural changes in the optimization problem caused by moving obstacles. To demonstrate the effectiveness of the approach, the robot imitates pick‐and‐place tasks while avoiding self‐collisions, semistatic, and dynamic obstacles, including a person. The analysis of the approach concerns computation time, constraint violations, and smoothness. It shows that after model identification, order reduction, and validation on the real robot, parallel integrators with compensation for input delays exhibit the best compromise between accuracy and computational complexity. The model predictive controller can successfully approach a moving target configuration without prior knowledge of the reference motion. The results show that pure hard constraints are not sufficient and lead to nonsmooth controls. In combination with soft constraints, which evaluate the proximity of obstacles, smooth and safe trajectories are planned.
Curriculum and instruction for the gifted: The role of school psychologists
Authors: Shaunessy‐Dedrick Elizabeth , Lazarou Barbara 
Published: April 2020

AbstractThis paper explores the school psychologist's role in the academic and psychosocial development of students identified as gifted and talented via curriculum. Given the school psychologists' assessment expertize, they can inform the identification to service placement process for students, including advocacy for curricular and instructional opportunities that best meet the student's needs. We discuss modern conceptualizations of giftedness and talent development, the function of curriculum and instruction in meeting the needs of students who are gifted and the school psychologist's role in identifying which curricular adaptations are appropriate for students based on learner data. We also discuss how a school psychologist can work with educators to support the needs of twice exceptional learners and gay, lesbian, bisexual, transgender and questioning students and recommend professional learning opportunities for school psychologists to remain abreast of current issues in gifted education.
Two organelle RNA recognition motif proteins affect distinct sets of RNA editing sites in the Arabidopsis thaliana plastid
Authors: Searing Audrey M. , Satyanarayan Manasa B. , O′Donnell James P. , Lu Yan 
Published: April 2020

AbstractPlastid and mitochondrial RNAs in vascular plants are subjected to cytidine‐to‐uridine editing. The model plant species Arabidopsis thaliana (Arabidopsis) has two nuclear‐encoded plastid‐targeted organelle RNA recognition motif (ORRM) proteins: ORRM1 and ORRM6. In the orrm1 mutant, 21 plastid RNA editing sites were affected but none are essential to photosynthesis. In the orrm6 mutants, two plastid RNA editing sites were affected: psbF‐C77 and accD‐C794. Because psbF encodes the β subunit of cytochrome b559 in photosystem II, which is essential to photosynthesis, the orrm6 mutants were much smaller than the wild type. In addition, the orrm6 mutants had pale green leaves and reduced photosynthetic efficiency. To investigate the functional relationship between ORRM1 and ORRM6, we generated orrm1 orrm6 double homozygous mutants. Morphological and physiological analyses showed that the orrm1 orrm6 double mutants had a smaller plant size, reduced chlorophyll contents, and decreased photosynthetic efficiency, similar to the orrm6 single mutants. Although the orrm1 orrm6 double mutants adopted the phenotype of the orrm6 single mutants, the total number of plastid RNA editing sites affected in the orrm1 orrm6 double mutants was the sum of the sites affected in the orrm1 and orrm6 single mutants. These data suggest that ORRM1 and ORRM6 are in charge of distinct sets of plastid RNA editing sites and that simultaneous mutations in ORRM1 and ORRM6 genes do not cause additional reduction in editing extent at other plastid RNA editing sites.
Phenomic selection and prediction of maize grain yield from near‐infrared reflectance spectroscopy of kernels
Authors: Lane Holly M. , Murray Seth C. , Montesinos‑López Osval A. , Montesinos‑López Abelardo , Crossa José , Rooney David K. , Barrero‐Farfan Ivan D. , De La Fuente Gerald N. , Morgan Cristine L. S. 
Published: April 2020

AbstractHigh‐throughput phenotyping technologies, which can generate large volumes of data at low costs, may be used to indirectly predict yield. We explore this concept, using high‐throughput phenotype information from Fourier transformed near‐infrared reflectance spectroscopy (NIRS) of harvested kernels to predict parental grain yield in maize (Zea mays L.), and demonstrate a proof of concept for phenomic‐based models in maize breeding. A dataset of 2,563 whole‐kernel samples from a diversity panel of 346 hybrid testcrosses were scanned on a plot basis using NIRS. Scans consisted of 3,076 wavenumbers (bands) in the range of 4,000–10,000 cm−1. Corresponding grain yield for each sample was used to train phenomic prediction and selection models using three types of statistical learning: (a) partial least square regression (PLSR), (b) NIRS best linear unbiased predictor (NIRS BLUP), and (c) functional regression. Our results found that NIRS data were a useful tool to predict maize grain yield and showed promising results for evaluating genetically independent breeding populations. All model types were successful; functional regression followed by the PLSR model resulted in the best predictions. Pearson's correlations between predicted and observed grain yields exceeded .7 in many cases within random cross validation. Partial least squares regression also showed promise on independent breeding trials. More research on predicting phenotypic traits from spectra will provide better understanding how NIRS and other phenomic technology can be used in predicting phenotypes of breeding programs.
Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life
Authors: Harvey Soriah M. , Murphy Vanessa E. , Gibson Peter G. , Collison Adam , Robinson Paul , Sly Peter D. , Mattes Joerg , Jensen Megan E. 
Published: April 2020

AbstractMaternal asthma increases the risk of infant wheeze. Breastfeeding may offer protection but there is limited evidence in this high‐risk group. We examined associations between breastfeeding and respiratory outcomes, in infants born to women with asthma. This study was a secondary analysis of two prospective cohorts of pregnant women with asthma, and their infants, conducted between 2007 and 2018. At 6 ± 1 (T1) and 12 ± 1 (T2) months post‐partum, mothers reported breastfeeding patterns and infant wheeze (primary outcome), bronchiolitis, and related medication use and healthcare utilization, via a validated questionnaire; a subgroup completed face‐to‐face interviews. χ2 tests and logistic regression models, adjusting for confounders, were utilized. Data were complete for 605 participants at T1 and 486 (80%) at T2. Of 605 participants: 89% initiated breastfeeding and 38% breastfed for more than 6 months. Breastfeeding for more than 6 months vs “never” was associated with a reduced adjusted relative risk of infant wheeze at T1 (0.54, 95% confidence interval, 0.30‐0.96). Bronchiolitis risk was reduced at T1 and T2 with more tha 6 months of breastfeeding vs “never.” Breastfeeding duration of 1 to 3 months, 4 to 6 months, and more than 6 months were associated with a reduced risk of infant healthcare utilization (all P < .05, vs “never”), but not medication use (P > .05). Breastfeeding for more than 6 months was associated with a reduced risk of wheeze, bronchiolitis, and wheeze‐related healthcare utilization in infants at risk due to maternal asthma. Notably, breastfeeding for shorter durations was associated with a reduced risk of healthcare utilization compared with none. Larger cohorts are needed to further examine the impact of breastfeeding exposure on respiratory health in infants exposed to maternal asthma.
A pH‐Dependent Colorimetric Probe Based on Sodium Dodecyl Sulfate Silver Nanoparticles for Cadmium(II) and Aluminum(III) Determination
Authors: Lin Xi , He Shunzhen , Xuan Dongliang , Liang Hao , Xiao Fubing , Li Feifei , Liu Can , Fan Pengfei , Hu Congcong , Yang Shengyuan 
Published: April 2020

AbstractA novel pH‐dependent sensitive and convenient assay was proposed for the determination of Cd2+ and Al3+ in aqueous medium using the sodium dodecyl sulfate (SDS) modified AgNPs as signal probes. In different pH values, the probe showed a visually detectable color change based on the strong interaction of Cd2+ and Al3+ with SDS. The color of SDS‐AgNPs solution would change from bright yellow to purple red in the presence of Cd2+ at pH 9.8, and to reddish brown in the presence of Al3+ at pH 5.5. Under the optimum experimental conditions, the ratio of A580 nm/A390 nm of SDS‐AgNPs gradually increased with increasing of Cd2+, and a good linear relationship was achieved when Cd2+ concentration ranging from 4.2×10−8 M to 3.0×10−6 M. Linear decreasing of A390 nm related to Al3+ concentration was over the range of 3.6×10−8 M to 2.0×10−6 M. The limit of detection was as low as 11.2 nM Cd2+ and 7.2 nM Al3+, respectively. Importantly, it has been successfully applied to detect Cd2+ and Al3+ in real samples.
Cellulose Membrane Composited with ZIF‐8 for Selective Separation of Rhodamine B
Authors: Chen Lu , Wang Fuxiang , Yang Weiting , Gu Dongxu , Li MeiLing , Pan Qinhe 
Published: April 2020

AbstractA composite membrane was prepared by in‐situ synthesis of ZIF‐8 on cellulose matrix in alkali/urea system. SEM revealed that ZIF‐8 particles are uniformly dispersed and tightly wrapped around the regenerated cellulose membrane which features a three‐dimensional porous structure. XRD, XPS and IR demonstrated the successful synthesis of ZIF‐8 on cellulose. Dye filtration experiments revealed high rejection rate (96 %) and selectivity for rhodamine B. Moreover, the composite membrane exhibited good cycling behavior with the rejection rate staying over 84 % after five cycles. The finding in this work provides a strategy for the rational design and fabrication of composite materials of cellulose and MOFs with promising application for wastewater purification.
Nanoparticle‐Based Platform for Activatable Fluorescence Imaging and Photothermal Ablation of Endometriosis
Authors: Moses Abraham S. , Taratula Olena R. , Lee Hyelim , Luo Fangzhou , Grenz Tanner , Korzun Tetiana , Lorenz Anna St , Sabei Fahad Y. , Bracha Shay , Alani Adam W. G. , Slayden Ov D. , Taratula Oleh 
Published: April 2020

AbstractEndometriosis is a painful disorder where endometrium‐like tissue forms lesions outside of the uterine cavity. Intraoperative identification and removal of these lesions are difficult. This study presents a nanoplatform that concurrently delineates and ablates endometriosis tissues using real‐time near‐infrared (NIR) fluorescence and photothermal therapy (PTT). The nanoplatform consists of a dye, silicon naphthalocyanine (SiNc), capable of both NIR fluorescence imaging and PTT, and a polymeric nanoparticle as a SiNc carrier to endometriosis tissue following systemic administration. To achieve high contrast during fluorescence imaging of endometriotic lesions, nanoparticles are constructed to be non‐fluorescent prior to internalization by endometriosis cells. In vitro studies confirm that these nanoparticles activate the fluorescence signal following internalization in macaque endometrial stromal cells and ablate them by increasing cellular temperature to 53 °C upon interaction with NIR light. To demonstrate in vivo efficiency of the nanoparticles, biopsies of endometrium and endometriosis from rhesus macaques are transplanted into immunodeficient mice. Imaging with the intraoperative Fluobeam 800 system reveals that 24 h following intravenous injection, nanoparticles efficiently accumulate in, and demarcate, endometriotic grafts with fluorescence. Finally, the nanoparticles increase the temperature of endometriotic grafts up to 47 °C upon exposure to NIR light, completely eradicating them after a single treatment.