bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurochemical Differences in Spinocerebellar Ataxia Type 14 and 1
Authors: Grosch Anne Sophie , Rinnenthal Jan Leo , Rönnefarth Maria , Lux Silke , Scheel Michael , Endres Matthias , Brandt Alexander U. , Paul Friedemann , Schmitz-Hübsch Tanja , Minnerop Martina , Doss Sarah 
Published: October 2020

AbstractAutosomal-dominant spinocerebellar ataxias (SCA) are neurodegenerative diseases characterized by progressive ataxia. Here, we report on neurometabolic alterations in spinocerebellar ataxia type 1 (SCA1; SCA-ATXN1) and 14 (SCA14; SCA-PRKCG) assessed by non-invasive 1H magnetic resonance spectroscopy. Three Tesla 1H magnetic resonance spectroscopy was performed in 17 SCA14, 14 SCA1 patients, and in 31 healthy volunteers. We assessed metabolites in the cerebellar vermis, right cerebellar hemisphere, pons, prefrontal, and motor cortex. Additionally, clinical characteristics were obtained for each patient to correlate them with metabolites. In SCA14, metabolic changes were restricted to the cerebellar vermis compared with widespread neurochemical alterations in SCA1. In SCA14, total N-acetylaspartate (tNAA) was reduced in the vermis by 34%. In SCA1, tNAA was reduced in the vermis (24%), cerebellar hemisphere (26%), and pons (25%). SCA14 patients showed 24% lower glutamate+glutamine (Glx) and 46% lower γ-aminobutyric acid (GABA) in the vermis, while SCA1 patients showed no alterations in Glx and GABA. SCA1 revealed a decrease of aspartate (Asp) in the vermis (62%) and an elevation in the prefrontal cortex (130%) as well as an elevation of myo-inositol (Ins) in the cerebellar hemisphere (51%) and pons (46%). No changes of Asp and Ins were detected in SCA14. Beyond, glucose (Glc) was increased in the vermis of both SCA14 (155%) and SCA1 (247%). 1H magnetic resonance spectroscopy revealed differing neurochemical profiles in SCA1 and SCA14 and confirmed metabolic changes that may be indicative for neuronal loss and dysfunctional energy metabolism. Therefore, 1H magnetic resonance spectroscopy represents a helpful tool for in-vivo tracking of disease-specific pathophysiology.
Dual-purpose production of eggs and meat—part 2: hens of crosses between layer and meat breeds show moderate laying performance but choose feed with less protein than a layer hybrid, indicating the potential to reduce protein in diets
Authors: Baldinger L. , Bussemas R. 
Published: October 2020

AbstractThe use of modern chicken genotypes with high egg or meat performance results in the ethically unacceptable practice of culling day-old male layer chicks because of their inefficient fattening performance. Dual-purpose genotypes with a balanced performance profile for eggs and meat are one option to avoid this practice. In this study, the performance of four crosses of a layer breed (White Rock or New Hampshire) and the meat breed Bresse Gauloise, purebred Bresse Gauloise and the layer hybrid Lohmann Sandy was compared under organic husbandry conditions. Part 2 focuses on the laying performance of the hens until the age of 72 weeks and their feed choices when offered energy-rich and protein-rich feed mixtures. Feed consumption was generally high (133–143 g day−1), but the crosses consumed less protein feed than Lohmann Sandy, indicating a potential to reduce the proportion of high-protein components. Bresse Gauloise × White Rock showed severe plumage loss due to feather pecking, which was most likely caused by their low consumption of protein feed. Apparently, free-choice feeding did not agree with this genotype. Average laying performance of the crosses was 68–73% total eggs per average hen, which can be considered moderate. Average egg weights and egg size distribution were comparable with Lohmann Sandy, while slaughter performance of the senior hens was comparable with purebred Bresse Gauloise. Based on these findings, egg production with dual-purpose laying hens can be an ethically desirable alternative to high-performance genotypes, but will require further research on optimal feeding strategies and animal behaviour.Trial registered on July 7, 2017 (reference number V 241-26532/2017)
The Levels and Trends in Deep and Extreme Poverty in the United States, 1993–2016
Authors: Brady David , Parolin Zachary 
Published: October 2020

AbstractRecently, there has been tremendous interest in deep and extreme poverty in the United States. We advance beyond prior research by using higher-quality data, improving measurement, and following leading standards in international income research. We estimate deep (less than 20% of medians) and extreme (less than 10% of medians) poverty in the United States from 1993 to 2016. Using the Current Population Survey, we match the income definition of the Luxembourg Income Study and adjust for underreporting using the Urban Institute’s TRIM3 model. In 2016, we estimate that 5.2 to 7.2 million Americans (1.6% to 2.2%) were deeply poor and 2.6 to 3.7 million (0.8% to 1.2%) were extremely poor. Although deep and extreme poverty fluctuated over time, including declines from 1993 to 1995 and 2007 to 2010, we find significant increases from lows in 1995 to peaks in 2016 in both deep (increases of 48% to 93%) and extreme poverty (increases of 54% to 111%). We even find significant increases with thresholds anchored at 1993 medians. With homelessness added, deep poverty would be 7% to 8% higher and extreme poverty 19% to 23% higher in 2016, which suggests that our estimates are probably lower bounds. The rise of deep/extreme poverty is concentrated among childless households. Among households with children, the expansion of SNAP benefits has led to declines in deep/extreme poverty. Ultimately, we demonstrate that estimates of deep/extreme poverty depend critically on the quality of income measurement.
Recent advances in the formulation of PLGA microparticles for controlled drug delivery
Authors: Lagreca Elena , Onesto Valentina , Di Natale Concetta , La Manna Sara , Netti Paolo Antonio , Vecchione Raffaele 
Published: October 2020

AbstractPolymeric microparticles (MPs) are recognized as very popular carriers to increase the bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different kinds of polymers, poly-(lactic-co-glycolic acid) (PLGA) is one of the most accepted materials for this purpose, because of its biodegradability (due to the presence of ester linkages that are degraded by hydrolysis in aqueous environments) and safety (PLGA is a Food and Drug Administration (FDA)-approved compound). Moreover, its biodegradability depends on the number of glycolide units present in the structure, indeed, lower glycol content results in an increased degradation time and conversely a higher monomer unit number results in a decreased time. Due to this feature, it is possible to design and fabricate MPs with a programmable and time-controlled drug release. Many approaches and procedures can be used to prepare MPs. The chosen fabrication methodology influences size, stability, entrapment efficiency, and MPs release kinetics. For example, lipophilic drugs as chemotherapeutic agents (doxorubicin), anti-inflammatory non-steroidal (indomethacin), and nutraceuticals (curcumin) were successfully encapsulated in MPs prepared by single emulsion technique, while water-soluble compounds, such as aptamer, peptides and proteins, involved the use of double emulsion systems to provide a hydrophilic compartment and prevent molecular degradation. The purpose of this review is to provide an overview about the preparation and characterization of drug-loaded PLGA MPs obtained by single, double emulsion and microfluidic techniques, and their current applications in the pharmaceutical industry.Graphic abstract
Viscosity solutions for the crystalline mean curvature flow with a nonuniform driving force term
Authors: Giga Yoshikazu , Požár Norbert 
Published: October 2020

AbstractA general purely crystalline mean curvature flow equation with a nonuniform driving force term is considered. The unique existence of a level set flow is established when the driving force term is continuous and spatially Lipschitz uniformly in time. By introducing a suitable notion of a solution a comparison principle of continuous solutions is established for equations including the level set equations. An existence of a solution is obtained by stability and approximation by smoother problems. A necessary equi-continuity of approximate solutions is established. It should be noted that the value of crystalline curvature may depend not only on the geometry of evolving surfaces but also on the driving force if it is spatially inhomogeneous.
Gender and Christian Ethics
Authors: Thatcher Adrian 
Published: October 2020

In this book, Adrian Thatcher offers fresh theological arguments for expanding our understanding of gender. He begins by describing the various meanings of gender and depicts the relations between women and men as a pervasive human and global problem. Thatcher then critiques naive and harmful theological accounts of sexuality and gender as binary opposites or mistaken identities. Demonstrating that the gendered theologies of Hans Urs von Balthasar and Karl Barth, as well as the Vatican's “war on gender” rest on questionable binary models, he replaces these models with a human continuum that allows for sexual difference without assuming “opposite sexes” and normative sexualities. Grounded in core Christian doctrines, this continuum enables a full theological affirmation of LGBTIQ people. Thatcher also addresses the excesses of the male/female binary in secular culture and outlines a hermeneutic that delivers justice and acceptance instead of sexism and discrimination.
Use of social media and online dating among individuals with a history of affective disorder
Authors: Rydahl Klara F. K. , Brund René B. K. , Medici Clara R. , Hansen Vibeke , Straarup Krista N. , Straszek Sune P. V. , Østergaard Søren D. 
Published: October 2020

AbstractObjectives:To investigate how individuals with a history of affective disorder use and perceive their use of social media and online dating.Methods:A questionnaire focusing on affective disorders and the use of social media and online dating was handed out to outpatients from unipolar depression and bipolar disorder clinics and general practice patients with or without a history of affective disorders (latter as controls). The association between affective disorders and use of social media and online dating was analysed using linear/logistic regression.Results:A total of 194 individuals with a history of unipolar depression, 124 individuals with a history of bipolar disorder and 196 controls were included in the analysis. Having a history of unipolar depression or bipolar disorder was not associated with the time spent on social media compared with controls. Using the controls as reference, having a history bipolar disorder was associated with use of online dating (adjusted odds ratio: 2.2 (95% CI: 1.3; 3.7)). The use of social media and online dating had a mood-congruent pattern with decreased and more passive use during depressive episodes, and increased and more active use during hypomanic/manic episodes. Among the respondents with a history of affective disorder, 51% reported that social media use had an aggravating effect on symptoms during mood episodes, while 10% reported a beneficial effect. For online dating, the equivalent proportions were 49% (aggravation) and 20% (benefit), respectively.Conclusion:The use of social media and online dating seems related to symptom deterioration among individuals with affective disorder.
Fasting and refeeding cycles alter subcutaneous white depot growth dynamics and the morphology of brown adipose tissue in female rats
Authors: Rosas Fernández Mariana , Concha Vilca Carlos , Batista Leandro O. , Figueiredo Letícia S. , Ribeiro Rosane A. , Tavares do Carmo Maria das Graças , Albuquerque Kelse T. 
Published: October 2020

AbstractIntermittent food restriction (IFR) is used mainly for weight loss; however, its effects on adipose tissue are not known when alternating with an obesogenic diet. To demonstrate its effects on morphological dynamics of fat deposits, female Wistar rats were distributed into groups: standard control (ST-C), with commercial diet; DIO control (DIO-C), with a diet that induces obesity (DIO) during the first and last 15 d, replaced by a standard diet for thirty intermediate days; standard restricted (ST-R), with standard diet during the first and last 15 d, with six cycles of IFR at 50 % of ST-C; and DIO restricted (DIO-R), in DIO during the first and last 15 d, with six cycles of IFR at 50 % of DIO-C. At 105 d of life, white adipose tissue (WAT) and brown adipose tissue (BAT) deposits were collected, weighed and histology performed. The DIO-R group showed higher total food intake (DIO-R 10 768·0 (SEM 357·52) kJ/g v. DIO-C 8868·6 (SEM 249·25) kJ/g, P < 0·0001), energy efficiency during RAI (DIO-R 2·26 (SEM 0·05) g/kJ v. DIO-C 0·70 (SEM 0·03) g/kJ, P < 0·0001) and WAT (DIO-R 5·65 (SEM 0·30) g/100 g v. DIO-C 4·56 (SEM 0·30) g/100 g) than their respective control. Furthermore, IFR groups presented hypertrophy of WAT and BAT, as well as fibrosis in BAT. Thus, IFR can establish prospective resistance to weight loss by favouring changes in adipose tissue morphology, increased energy intake and efficiency. Finally, the DIO diet before and after IFR aggravates the damages caused by the restriction.
Irregular daily energy intake and diet quality in Iranian adults
Authors: Jayedi Ahmad , Lesani Azadeh , Akbarzadeh Zahra , Djafarian Kurosh , Shab-Bidar Sakineh 
Published: October 2020

AbstractThe present cross-sectional study aimed to assess the association of daily irregularity in energy intake and diet quality among apparently healthy adults in Iran. The research was conducted on 850 adult men and women (age range: 20–59 years) who attended health care centres in Tehran. Dietary intake was assessed by three, 24-h dietary recalls. Diet quality was assessed using the Dietary Approaches to Stop Hypertension (DASH) diet score and Healthy Eating Index-2015 (HEI-2015). An irregularity score of daily energy intake was calculated based on the deviation from the 3-d mean energy intake, with a higher score indicating more fluctuations in daily energy intake. Multiple linear regression analysis was used to assess the association of irregularity score of daily energy intake with food group intakes and DASH diet score and HEI-2015, controlling for age, sex, BMI, physical activity, education level and occupation status. The range of irregularity score was 0·55–133·3 (22·4 (sd 19·0)). Higher irregularity score of daily energy intake was significantly associated with a lower consumption of fruit, vegetables, legumes, low-fat dairy products and poultry, higher consumption of soft drinks, processed meat and nuts, and lower overall DASH diet score and HEI-2015. Overall, our findings showed that more day-to-day variations in energy intake may be correlated with a lower diet quality. More research is needed to confirm the associations observed in the present study and to clarify potential mechanisms explaining these associations.
Community engagement in Health Technology Assessment and beyond: from guests in the process to hosts
Authors: Holliday Catherine M. 
Published: October 2020

Abstract
In Health Technology Assessment (HTA), clinical and economic evidence are assessed in the regulatory and reimbursement environments, with community input considered as complementary to this. Stakeholders are calling for more meaningful community engagement, but this will not be reached without a significant shift. The Centre for Community-Driven Research (CCDR) is a nonprofit organization bringing much needed change to the way we think about community engagement in health. This article is based on CCDR's experience and outlines three system changes needed to advance community engagement in decisions about health and HTA. This paper comes from the perspective of engaging everyday people in the process as opposed to representation on panels and committees. The three key areas of change that are discussed include building holistic evidence, creating supportive environments, and infrastructure for community engagement, with the term community referring to people affected by disease or health conditions and their carers/families.
Predictors of mortality among multidrug-resistant tuberculosis patients in central Ethiopia: a retrospective follow-up study
Authors: Kassa Getahun Molla , Tadesse Abilo , Gelaw Yalemzewod Assefa , Alemayehu Temesgen Tadesse , Tsegaye Adino Tesfahun , Tamirat Koku Sisay , Akalu Temesgen Yihunie 
Published: October 2020

Abstract
The burden of multidrug-resistant tuberculosis (MDR-TB) related to mortality in resource-poor countries remains high. This study aimed to estimate the incidence and predictors of death among MDR-TB patients in central Ethiopia. A retrospective follow-up study was conducted at three hospitals in the Amhara region on 451 patients receiving treatment for MDR-TB from September 2010 to January 2017. Data were collected from patient registration books, charts and computer databases. Data were fitted to a parametric frailty model and survival was expressed as an adjusted hazard ratio (AHR) with a 95% confidence interval (CI). The median follow-up time of participants was 20 months (interquartile range: 12, 22) and 46 (10.20%) of patients died during this period. The incidence rate of mortality was 7.42 (95% CI 5.56–9.91)/100 person-years. Older age (AHR = 1.04, 95% CI 1.01–1.08), inability to self-care (AHR = 13.71, 95% CI 5.46–34.40), co-morbidity (AHR = 5.74, 95% CI 2.19–15.08), low body mass index (AHR = 4.13, 95% CI 1.02–16.64), acute lung complications (AHR = 4.22, 95% CI 1.66–10.70) and lung consolidation at baseline (AHR = 5.27, 95% CI 1.06–26.18) were independent predictors of mortality. Most of the identified predictor factors of death in this study were considered to be avoidable if the TB programme had provided nutritional support for malnourished patients and ensured a close follow-up of the elderly, and patients with co-morbidities.
Advances in the study of zygote activation in higher plants
Authors: Li Dong Xiao , Chen Shi Jun , Tian Hui Qiao 
Published: October 2020

SummaryIn higher plants, fertilization induces many structural and physiological changes in the fertilized egg that reflect the transition from the haploid female gamete to the diploid zygote – the first cell of the sporophyte. After fusion of the egg nucleus with the sperm nucleus, many molecular changes occur in the zygote during the process of zygote activation during embryogenesis. The zygote originates from the egg, from which some pre-stored translation initiation factors transfer into the zygote and function during zygote activation. This indicates that the control of zygote activation is pre-set in the egg. After the egg and sperm nuclei fuse, gene expression is activated in the zygote, and paternal and maternal gene expression patterns are displayed. This highlights the diversity of zygotic genome activation in higher plants. In addition to new gene expression in the zygote, some genes show quantitative changes in expression. The asymmetrical division of the zygote produces an apical cell and a basal cell that have different destinies during plant reconstruction; these destinies are determined in the zygote. This review describes significant advances in research on the mechanisms controlling zygote activation in higher plants.
Consumption of multiple micronutrients or small-quantity lipid-based nutrient supplements containing iodine at the recommended dose during pregnancy, compared with iron and folic acid, does not affect women’s urinary iodine concentration in rural Malawi: a secondary outcome analysis of the iLiNS DYAD trial
Authors: Adu-Afarwuah Seth , Arnold Charles D , Maleta Kenneth , Ashorn Per , Ashorn Ulla , Jorgensen Josh M , Fan Yue-Mei , Nkhoma Minyanga , Bendabenda Jaden , Matchado Andrew , Dewey Kathryn G 
Published: October 2020

AbstractObjectives:Inadequate iodine intake during pregnancy increases the risk of neonatal morbidity and mortality. We aimed to evaluate whether prenatal supplements containing iodine affect urinary iodine concentrations (UIC) of pregnant women in Malawi.Design:A randomised controlled trial. Pregnant women (n 1391) were assigned to consume 60 mg/d Fe and 400 µg/d folic acid (IFA) or 18 vitamins and minerals including 250 µg/d iodine (MMN) or 20 g/d small-quantity lipid-based nutrient supplements (SQ-LNS) with similar nutrient contents as MMN group, plus macronutrients (LNS) until childbirth. In a sub-study (n 317), we evaluated group geometric mean urinary iodine concentration (UIC) (µg/L) at 36 weeks of gestation controlling for baseline UIC and compared median (baseline) and geometric mean (36 weeks) UIC with WHO cut-offs: UIC < 150, 150–249, 250–499 and ≥500 reflecting insufficient, adequate, above requirements and excessive iodine intakes, respectively.Setting:Mangochi District, Malawi.Participants:Women ≤20 weeks pregnant.Results:Groups had comparable background characteristics. At baseline, overall median (Q1, Q3) UIC (319 (167, 559)) suggested iodine intakes above requirements. At 36 weeks, the geometric mean (95 % CI) UIC of the IFA (197 (171, 226)), MMN (212 (185, 243)) and LNS (220 (192, 253)) groups did not differ (P = 0·53) and reflected adequate intakes.Conclusions:In this setting, provision of supplements containing iodine at the recommended dose to pregnant women with relatively high iodine intakes at baseline, presumably from iodised salt, has no impact on the women’s UIC. Regular monitoring of the iodine status of pregnant women in such settings is advisable. Clinicaltrials.gov identifier: NCT01239693.
Double burden of malnutrition and its association with infant and young child feeding practices among children under-five in Thailand
Authors: Benedict Leshawn , Hong Seo Ah , Winichagoon Pattanee , Tejativaddhana Phudit , Kasemsup Vijj 
Published: October 2020

AbstractObjective:This study examined the prevalence of stunting-overweight and socio-demographic determinants among children under-five years of age, as well as associations with infant and young child feeding (IYCF) among children aged 6–23 months.Design:Secondary data analysis based on the Thailand Multiple Indicator Cluster Survey 2015–2016.Setting:Cross-national study.Participants:Nationally representative sample of children under-five years of age (n 12 313).Results:The prevalence of wasting, stunting, overweight and stunting-overweight was 5·3, 10·5, 10·1 and 1·6 %, respectively. In multivariate analyses, children under 6 months, children from low and middle wealth tertiles, and children living in rural areas were prone to being wasted. Male children, low wealth tertile and a non-Thai speaking household head were positively and children aged 48–59 months and a one-child household were inversely associated with stunting. Children from a low wealth tertile were less likely to be overweight, while older age, male children and children from a one-child household were more likely to be overweight. Stunting-overweight was associated with children aged 24–47 months, male children, mothers having secondary education, a one-child household, a non-Thai speaking household head and an urban area. In terms of IYCF indicators, despite no association with stunting and stunted-overweight children, current breast-feeding and inadequate meal frequency were associated with being wasting, while current breast-feeding and dietary diversity were inversely associated with being overweight.Conclusions:This study revealed the double burden of malnutrition at the individual and population levels among Thai children under-five, which calls for concrete integrated interventions to tackle all forms of malnutrition.