bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of serum albumin and derived neutrophil-to-lymphocyte ratio score in assessment of disease activity in rheumatoid arthritis patients
Authors: Ganeb Sahar , Egaila Sami , Hamed Asmaa , Hassan Waleed 
Published: August 2020

Abstract
Background
Albumin and derived neutrophil to lymphocyte ratio (dNLR) are known biomarkers that can reflect systemic inflammation and it has been hypothesized that combination of both markers in one score (albumin-dNLR score) can be useful in monitoring rheumatoid arthritis (RA) patients. The current study intended to measure albumin -dNLR score in patients with RA in the order to find whether these new biomarkers could reflect the activity of the disease and the articular activity detected by ultrasonography. We measured serum albumin and dNLR in blood samples obtained from 100 RA patients and from 100 apparently healthy controls (HC). Albumin -dNLR score was calculated according to the presence of hypoalbuminemia (≤ 3.76 gm/dl) and/or raised dNLR (>1.37).

Results
RA patients had a significantly elevated dNLR (p< 0.001) and albumin-dNLR score (p< 0.001) compared to their levels in HC, while serum albumin was significantly decreased (p< 0.001) in RA patients than its level in HC. In RA patients, albumin-dNLR score correlated significantly with DAS28 (p< 0.001), erythrocyte sedimentation rate (ESR) (p< 0.001), C-reactive protein (p< 0.001), grey scale (p< 0.001), power Doppler (p< 0.001) and total ultrasound score (p< 0.001). Also, tender joint count, ESR and albumin-dNLR score were significant predictors of DAS28 in multivariate regression analysis.

Conclusions
Our study settled that albumin - dNLR score is increased in RA patients than in healthy subjects. The score correlated well with DAS28, acute phase reactants, and ultrasonographic synovitis scores implying that it could be an easy valuable biomarker to monitor RA disease activity.
Digital Commemorations of Slave Revolt
Authors: Lauro Sarah Juliet 
Published: August 2020

Abstract
This article presents, troubles, and ultimately seeks to answer two simple questions: What does the digitization of slave resistance look like, and can it serve as a virtual memorial commemorating historic events where markers are lacking in geographic places, such as locations where slave revolts occurred? In four main parts, this article presents an example of digital commemoration of slave resistance in a now defunct online list of shipboard rebellions; it then contrasts this digital resource to material monuments to slave revolt leaders and to diverse types of museum displays (as at the International Museum of Slavery at Liverpool); the next section profiles online resources about slave revolt, including Vincent Brown’s animated map of slave insurrections in Jamaica and repositories, archives, and databases of newspaper advertisements for runaways, arguing that these resources can sometimes be understood not merely as educational tools but also as digital commemorations of slave revolt. Finally, engaging with theory on monuments, memory, and history, this piece explains why digital commemorations existing in virtual space might productively acknowledge our discomfort with the existent archive and the insurmountable gaps in our knowledge of history.
Intravenous tranexamic acid reduces blood loss and transfusion requirements after periacetabular osteotomy
Authors: Levack Ashley E. , McLawhorn Alexander S. , Dodwell Emily , DelPizzo Kathryn , Nguyen Joseph , Sink Ernest 
Published: August 2020

AimsTranexamic acid (TXA) has been shown to reduce blood loss and transfusion requirements in patients undergoing orthopaedic surgery. There remains a lack of prospective evidence for the use of TXA in patients undergoing periacetabular osteotomy (PAO). The purpose of this study was to determine if intravenous (IV) TXA is effective in reducing calculated blood loss and transfusions after PAO.MethodsThis was a single-centre prospective double-blind placebo-controlled randomized trial of 81 patients aged 12 to 45 years undergoing elective PAO by a single surgeon. The intervention group (n = 40) received two doses of IV TXA of a maximum 1 g in each dose; the control group (n = 41) received two doses of 50 ml 0.9% saline IV. The primary outcome was perioperative calculated blood loss. Secondary outcomes included allogenic transfusions and six-week postoperative complications.ResultsThere were no differences in demographics or intraoperative variables between study groups. The TXA group demonstrated lower mean calculated blood loss (1,265 ml, (SD 321) vs 1,515 ml, (SD 394); p = 0.002) and lower frequency of allogenic transfusion (10%/n = 4 vs 37%/n = 15; p = 0.008). Regression analyses associated TXA use with significant reductions in calculated blood loss (p < 0.001) and transfusion (p = 0.007) after adjusting for age, sex, body mass index, preoperative haemoglobin, cell-saver volume, intraoperative mean arterial blood pressure, and operating time. No patients suffered venous thromboembolic complications.ConclusionIn this trial, IV TXA decreased postoperative calculated blood loss by 293 ml and reduced the frequency of allogenic transfusions by 73% (37% vs 10%) following PAO. TXA may be safe and effective for reducing blood loss in patients undergoing PAO. Cite this article: Bone Joint J 2020;102-B(9):1151–1157.
Bone density measurements from CT scans may predict the healing capacity of scaphoid waist fractures
Authors: Miyamura Satoshi , Lans Jonathan , He Janice J. , Murase Tsuyoshi , Jupiter Jesse B. , Chen Neal C. 
Published: August 2020

Aims We quantitatively compared the 3D bone density distributions on CT scans performed on scaphoid waist fractures subacutely that went on to union or nonunion, and assessed whether 2D CT evaluations correlate with 3D bone density evaluations. Methods We constructed 3D models from 17 scaphoid waist fracture CTs performed between four to 18 weeks after fracture that did not unite (nonunion group), 17 age-matched scaphoid waist fracture CTs that healed (union group), and 17 age-matched control CTs without injury (control group). We measured the 3D bone density for the distal and proximal fragments relative to the triquetrum bone density and compared findings among the three groups. We then performed bone density measurements using 2D CT and evaluated the correlation with 3D bone densities. We identified the optimal cutoff with diagnostic values of the 2D method to predict nonunion with receiver operating characteristic (ROC) curves. Results In the nonunion group, both the distal (100.2%) and proximal (126.6%) fragments had a significantly higher bone density compared to the union (distal: 85.7%; proximal: 108.3%) or control groups (distal: 91.6%; proximal: 109.1%) using the 3D bone density measurement, which were statistically significant for all comparisons. 2D measurements were highly correlated to 3D bone density measurements (Spearman’s correlation coefficient (R) = 0.85 to 0.95). Using 2D measurements, ROC curve analysis revealed the optimal cutoffs of 90.8% and 116.3% for distal and proximal fragments. This led to a sensitivity of 1.00 if either cutoff is met and a specificity of 0.82 when both cutoffs are met. Conclusion Using 3D modelling software, nonunions were found to exhibit bone density increases in both the distal and proximal fragments in CTs performed between four to 18 weeks after fracture during the course of treatment. 2D bone density measurements using standard CT scans correlate well with 3D models. In patients with scaphoid fractures, CT bone density measurements may be useful in predicting the likelihood of nonunion. Cite this article: Bone Joint J 2020;102-B(9):1200–1209.
Top ten research priorities for problematic knee arthroplasty
Authors: Mathews John A. , Kalson Nicholas S. , Tarrant Polly M. , Toms Andrew D. ,   Revision Knee Replacement Priority Setting Partnership steering group
Published: August 2020

Aims The James Lind Alliance aims to bring patients, carers, and clinicians together to identify uncertainties regarding care. A Priority Setting Partnership was established by the British Association for Surgery of the Knee in conjunction with the James Lind Alliance to identify research priorities related to the assessment, management, and rehabilitation of patients with persistent symptoms after knee arthroplasty. Methods The project was conducted using the James Lind Alliance protocol. A steering group was convened including patients, surgeons, anaesthetists, nurses, physiotherapists, and researchers. Partner organizations were recruited. A survey was conducted on a national scale through which patients, carers, and healthcare professionals submitted key unanswered questions relating to problematic knee arthroplasties. These were analyzed, aggregated, and synthesized into summary questions and the relevant evidence was checked. After confirming that these were not answered in the current literature, 32 questions were taken forward to an interim prioritization survey. Data from this survey informed a shortlist taken to a final consensus meeting. Results A total of 769 questions were received during the initial survey with national reach across the UK. These were refined into 32 unique questions by an independent information specialist. The interim prioritization survey was completed by 201 respondents and 25 questions were taken to a final consensus group meeting between patients, carers, and healthcare professionals. Consensus was reached for ranking the top ten questions for publication and dissemination. Conclusions The top ten research priorities focused on pain, infection, stiffness, health service configuration, surgical and non-surgical management strategies, and outcome measures. This list will guide funders and help focus research efforts within the knee arthroplasty community. Cite this article: Bone Joint J 2020;102-B(9):1176–1182.
Biological Effectiveness of Constructed Consortia in MEOR
Authors: KAIYRMANOVA Gulzhan , SHAIMERDENOVA Ulzhan , TAPESHOVA Shattyk , MAGMIYAYEV Ratbek , YERNAZAROVA Aliya 
Published: August 2020

Kazakhstan is one of the producers of oil and gas in the world. Also, Kazakhstan is a country which uses traditional methods of oil development. These methods are not economically beneficial in the development of oil since two-thirds of the oil remains in the ground. In this regard, 16 indigenous microorganisms were studied from the production water of the “Akingen” field located in Western Kazakhstan. It is known that biological preparations containing several symbiotic strains of microorganisms are important because they are more effective and improved with biotechnology properties than monobacterial preparations. Antagonistic activity of 16 indigenous strains of bacteria was examined by cross streak. In addition, the activities of the created consortia were studied (oil emulsification, production of acids and gas). 5 bacterial consortia were selected based on the study of the antagonistic relationships of strains and their activeness, including: 2 consortia consisting of 2 monostrains - P. aeruginosa D6: Bacillus sp. SR 1; P. aeruginosa D6: Bacillus sp. CL1; 2 consortia of 3 monostrains - P. aeruginosa D6: Bacillus sp. SR1: Bacillus sp. CL1; P. aeruginosa D6: Bacillus sp. CL1: Bacillus sp. D1X and one consortium of 4 monostrains P. aeruginosa D6: Bacillus sp. SR1: Bacillus sp. CL1: Bacillus sp. D1X.
Development of Organic Agriculture in the European Union Member States: The Role of Public-Private Partnership
Authors: POLUSHKINA Tatyana Mikhailovna , AKIMOVA Yulia Alekseevna , KOROLEVA Tatyana Petrovna , KOCHETKOVA Svetlana Andreevna , ZININA Lyubov Ivanovna 
Published: August 2020

This study focuses on the need to use public-private partnership (PPP) mechanisms in the development of organic agriculture in order to solve problems in the field of sustainable rural development, when economic well-being is achieved not through the environmental degradation that threatens human life and health, and especially the health of future generations, but in harmony with nature; and to improve food security of the country in the field of providing quality nutrition. The conclusion has been made that it is important and necessary to develop organic agriculture in the modern Russia to increase the sustainability of its development. The analysis of global trends in the development of the organic sector of agricultural production has been carried out. A review of the practice of applying PPP mechanisms in the development of this agricultural sector in Europe has been provided. The conclusion about PPP as an effective tool for bringing relations between agricultural organizations and the state to a new level has been justified, which will help create an efficient mechanism for updating fixed assets and, therefore, increase the level of agricultural production.
Efektivitas Pengawasan Kelembagaan dan Masyarakat Terhadap Kebijakan Penataan Ruang (Kawasan Cagar Alam Geologi Karangsambung)
Authors: Kusyuniadi Indraya , Buchori Imam 
Published: August 2020

Kawasan Cagar Alam Geologi Karangsambung (KCAGK) adalah kawasan yang mempunyai keunikan batuan dan fosil, sehingga mendapat julukan sebagai “Black Box” dari proses alam semesta. Berdasarkan kebijakan tata ruang (RTRW) menetapkan KCAGK sebagai kawasan strategis sebagai fungsi daya dukung lahan. Konsekuensinya adalah semua aktifitas yang dapat mengubah bentukan geologi dilarang. Akan tetapi kegiatan penambangan masih menjadi ancaman akan hilangnya keanekaragaman bebatuan yang dilindungi. Penelitian ini memfokuskan pada aspek pengawasan yang terindikasi masih lemah dalam penyelenggaraan pentaan ruang, melalui aspek kelembagaan dan masyarakat. Aspek kelembagaan terdiri dari Lembaga Ilmu Pengetahuan Indinesia (LIPI) dan pemerintah daerah melalui Badan Koordinasi Penataan Ruang Daerah (BKPRD), sedangkan aspek mayarakat diwakili tokoh lokal. Penelitian ini menggunakan pendekatan kuantitatif dengan teknik analisis studi statistik deskriptif. Proses penelitian diawali dengan menentukan jumlah populasi untuk lembaga LIPI dan BKPRD melalui purposive sampling diperoleh jumlah sampling sebesar 8 responden. Penentuan jumlah responden masyarakat yang diwakili tokoh masyarakat, menggunakan random sampling dengan teknik area probability diperoleh sampling sebesar 20 responden.Tahapan kedua adalah pengisian kuesioner melalui wawancara langsung ke responden. Tahapan ketiga adalah melakukan analisis efektivitas pengawasan kebijakan tata ruang melalui peran kelembagaan dan masyarakat. Hasil yang diperoleh dari penelitian ini adalah peran dari kelembagaan dan masyarakat belum efektiv dalam melakukan tahapan pengawasan Peraturan Daerah (Perda) RTRW di KCAGK. Indikator dari ketidak efektivan dilihat dari: 1) sosialisasi kebijakan, 2) perizinan penambangan, 3) penerapan insentif dan disinsentif, 4) pembiayaan dan 5) pemantauan dan kepedulian lingkungan. Perlu suatu perbaikan dalam meningkatkan peran kelembagaan dan masyarakat, diantaranya 1) Lembaga BKPRD perlu ditinjau ulang keberadaannya, 2) peran masyarakat perlu di berikan kewenagan lebih dalam pengawasan lingkungan di KCAGK.
Pemodelan Erosi dan Sedimentasi di DAS Bajulmati : Aplikasi Soil dan Water Assesment Tool (SWAT)
Authors: Sujarwo Mohamad Wawan , Indarto Indarto , Mandala Marga 
Published: August 2020

DAS bajulmati merupakan DAS kecil (± 173.4 km2) yang berada di wilayah timur pulau Jawa. DAS bajulmati memiliki iklim yang spesifik yaitu relatif kering dengan musim kemarau yang panjang (8-9 bulan selama setahun). Meskipun kondisi iklim yang kurang mendukung, sebagian besar masyarakat bekerja sebagai petani landang. Adanya perluasan lahan pertanian non irigasi/ladang mengakibatkan tutupan vegetasi semakin berkurang. Oleh karena itu, evaluasi DAS bajulmati diperlukan untuk mengetahui dampak perluasan lahan pertanian terhadap laju aliran dan sedimentasi dengan kondisi iklim yang cukup spesifik (kering). Salah satu model evaluasi pengelolaan DAS terhadap perubahan lahan adalah model SWAT (Soil and Water Assessment Tool). SWAT dapat menggambarkan proses hidrologi (erosi dan sedimentasi) unit lahan. data DEM resolusi (10x10 m) sebagai masukan utama untuk proses delinasi DAS. Data tanah, tutupan lahan, dan kontur digunakan untuk menentukan unit lahan/hydrolocal response unit (HRU) DAS. Data curah hujan dan iklim (suhu, kelembaban rata-rata, intensitas matahari, kecepatan angin) diperoleh dari stasiun yang tersebar di wilayah DAS. Semua data diintegrasikan ke dalam SWAT untuk menghitung proses hidrologi, erosi dan sedimentasi. Debit yang diamati digunakan untuk mengkalibrasi keluaran debit hasil SWAT di outlet DAS. Hasil kalibrasi debit menunjukkan nilai Nash-Sutcliffe Efficiency sebesar 0,53 dan validasi sebesar 0,5 serta koefisien determinasi sebesar 0,58 dan 0,78 (memuaskan) dan model dapat digunakan untuk ilustrasi proses hidrologi dalam DAS bajulmati. Analisis tingkat erosi SWAT menunjukkan bahwa 34,46; 39,19; dan 17,83 menunjukkan tingkat erosi sangat ringan sampai kategori sedang. Oleh karena itu, DAS Bajulmati masih dalam kategori aman karena rata-rata erosi berat dan sangat berat dibawah 10%. Nilai sedimentasi tertinggi pada HRU 512 dan SubDAS 23. Wilayah tersebut merupakan wilayah perkebunan dengan tingkat kemiringan diatas 40%.
Pengujian Toksisitas Lindi Instalasi Pengolahan Lindi TPA Piyungan pada Daphnia sp. dengan Whole Effluent Toxicity
Authors: Kartikasari Ika Bayu , Widyastuti M , Hadisusanto Suwarno 
Published: August 2020

Lindi adalah rembesan yang melalui tumpukan sampah hasil endapan yang berada di bawah landfill yang terakumulasi yang terdiri dari bahan organik dan anorganik. Lindi hasil pengolahan IPL TPA Piyungan masih memiliki potensi pencemaran lindi menjadi permasalahan yang masih memiliki nilai toksisitas yang tinggi. Perlu adanya pengukuran toksisitas untuk mengetahui pengaruh pencemaran lindi terhadap lingkungan. Penelitian ini bertujuan untuk: (1) melakukan analisis efektivitas hasil pengolahan lindi di IPL TPA Piyungan, dan (2) melakukan pengujian toksisitas akut dengan WET (Whole Effluent Toxicity) menggunakan Daphnia sp. pada pengolahan lindi. Metode penelitian yang digunakan dalam penelitian ini yakni melakukan uji laboratorium pada parameter pengolahan lindi yang disesuaikan dengan permen LHK No. 59 tahun 2016 untuk pengukuran efektivitas pengolahan lindi, uji LC50 untuk mengetahui tingkat tokisitas akut pada influen dan efluen pengolahan lindi. proses pengolahan lindi TPA Piyungan terdiri dari Kolam Sedimentasi, Aerasi, dan Desinfeksi. Hasil dari penelitian ini menunjukkan bahwa (1) Efektivitas pengolahan lindi TPA Piyungan pada parameter berturut-turut TSS 56 %; BOD 82 %; COD 0 %; TN 41,67%; dan Hg 14 %. Hasil efektivitas pengolahan lindi tersebut tidak mempengaruhi peningkatan perbaikan kualitas lindi yang disesuaikan Peraturan Menteri LHK No 59/Menlhk/Setjen/Kum.1/7/2016 masih melebihi baku mutu yang telah ditetapkan kecuali parameter BOD, (2) Toksisitas lindi TPA Piyungan dikategorikan Very High Acute Toxicity pada influen dan High Acute Toxicity efluen IPL Piyungan. Kematian 50% populasi daphnia untuk contoh uji influen IPL Piyungan sebesar 0,482% dengan Toxic Unit acute (TUa) sebesar 203,33. Contoh uji efluen IPL Piyungan sebesar 2,752% dengan Toxic Unit acute (TUa) sebesar 36,33.
Tipologi dan Resolusi Konflik Tenurial dalam Kawasan Hutan Konservasi Taman Wisata Alam Pantai Panjang-Pulau Baai di Kota Bengkulu
Authors: Senoaji Gunggung , Anwar Guswarni , Iskandar Iskandar 
Published: August 2020

Taman Wisata Alam Pantai Panjang-Pulau Baai di Kota Bengkulu merupakan kawasan hutan konservasi yang tujuan utamanya dimanfaatkan untuk kepentingan pariwisata alam dan rekreasi. Ekosistem pantai dan mangrove dengan segala kekayaan dan keindahan alamnya merupakan obyek daya tarik wisata kawasan ini. Pengelolaan kawasan wisata ini menghadapi permasalahan, yakni konflik hak atas lahan sehingga terjadi alih fungsi pemanfaatan lahan hutan. Penelitian ini bertujuan untuk menganalisis tipologi konflik tenurial dan alternatif penyelesaiannya. Kajian dilakukan dengan memetakan penggunaan lahan dan mengidentifikasi para pihak yang memanfaatkan kawasan taman wisata ini. Pendekatan sejarah dan yuridis digunakan untuk menentukan alternatif penyelesaian konflik tenurialnya. Hasil penelitian menunjukkan bahwa kawasan taman wisata alam ini belum ditetapkan sebagai kawasan hutan. Penetapan kawasan hutan tetap harus segera dilakukan agar dapat melakukan kepastian hukum dalam pengelolaan. Didalam kawasannya terdapat berbagai penggunaan lahan di luar bidang kehutanan. Tipologi konflik tenurial yang terjadi adalah : konflik pengelola dengan masyarakat, konflik pengelola dengan pemerintah, dan konflik pemerintah dengan perusahaan negara. Resolusi konflik yang ditawarkan adalah perubahan sebagian peruntukan kawasan hutan melalui skema revisi Rencana Tata Ruang Wilayah (RTRW) Provinsi Bengkulu dan kolaborasi pemanfaatan kawasan hutan taman hutan wisata dengan pengelola. Evaluasi kesesuaiaan fungsi taman wisata alam harus dilakukan dengan melibatkan semua pihak yang berkonflik didalamnya. Hasil evaluasi ini menjadi dasar dalam penetapan kawasan hutan taman wisata alam agar memiliki kekuatan hukum yang tetap.
ESTUDOS DE CASO: A EXPERIÊNCIA DO ENSINO E DA PESQUISA ALINHADOS A EXTENSÃO
Authors: Cunha Ananda Helena Nunes , Sampaio Gabryele Cardoso 
Published: August 2020

O objetivo do trabalho foi demonstrar, através de um estudo de caso, como algumas práticas pedagógicas podem associar ensino, pesquisa e extensão, utilizando como base a execução de atividades dentro de um projeto de extensão. Alunos de um curso técnico basearam seus estudos colaborando no projeto de extensão intitulado “Formação de educadores ambientais”. As atividades desenvolvidas foram: a montagem de uma horta em um Colégio Estadual Rui Barbosa, a visita técnica à feira Agro Centro-Oeste Familiar de 2018, e o dia de campo para plantio de mudas com a comunidade do Rotary. Os resultados obtidos permitem realizar uma análise do conhecimento dos alunos, orientando sobre como podemos auxiliar na preservação do meio ambiente e como a prática da mudança de atitude colabora com a divulgação da educação ambiental, destacando-se a importância de desenvolver essa consciência, que contribuirá para a preservação dele através da mobilização de alunos. As práticas são excelentes aliadas no processo de ensino/aprendizagem, e a busca pela qualidade de vida da comunidade através de projetos sociais e ambientais é crescente.
How Law Student Prepare Their Life to Survive?
Authors: Niravita Aprila , Sumardiana Benny , Wedhatami Bayangsari , Salam Syukron , Kamal Ubaidillah , Laskarwati Batari , Syariefudin Iqbal 
Published: August 2020

Character education is an important element in the effort to prepare superior Indonesian human resources, it is of particular concern to be applied especially among students, there is a need for character education because the attitudes and behavior of the people and people of Indonesia now tend to ignore the noble values ​​of Pancasila which are highly respected and should be rooted in everyday attitudes and behaviors, values ​​such as honesty, politeness, togetherness and religious, gradually eroded by foreign cultures that tend to be hedonistic, materialistic, and individualistic, so that the noble character values ​​are ignored in the future if students and young people are not equipped with character education. Law students have their own challenges, especially in the era of globalization. This paper analyzes and illustrates the character strengthening program for law student activists in Semarang State University through several programs, namely public speaking, strengthening student idealism, strengthening advocacy capacitation and human rights assistance and self-motivation. This research is a field research with the object of research as activists of law students who are members of student organizations. This research confirms that the programs for strengthening the character of students experience several obstacles, one of which is the model used and a relatively short time. However, character education for student activists helps students to survive in real life as part of community members.