bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance use Treatment and Harm Reduction Services for Migrants and Refugees in the COVID-19 Pandemic: Findings from a Global Survey
Authors: Jong Cornelis De , Farhoudian Ali , Vahidi Mehrnoosh , Ebrahimi Mohsen , Ekhtiari Hamed , Rafei Parnian , Busse Anja , Brady Kathleen , Yunesian Masud , Ezard Nadine , Radfar Ramin , Baldacchino Alexander 
Published: December 2020

Abstract
Migrants and refugees are considered vulnerable to mental health problems and substance use disorders; and may be particularly affected by service disruptions associated with the COVID-19 pandemic The International Society of Addiction Medicine (ISAM) ran a multi-phased global survey among clinicians and health professional that are actively working in the field of addiction medicine to investigate the impact of the COVID-19 pandemic on substance use and related services. In March 2020, the first month after the announcement of the pandemic by the World Health Organization, 177 informants from 77 countries took part in the global survey, and only 12.9% of them reported their countries’ substance use treatment and harm reduction services for the migrants and refugees with substance use disorders continued as usual. In May 2020, 11.7% of respondents of the second phase reported that the services for refugees and migrants improved in comparison to March 2020; 11.7% reported that these services in their country discontinued. Results suggest that refugee and migrants access to treatment and harm reduction services has been reduced as a result of COVID-19. It can be concluded that it is crucial to improve the visibility of migrants’ needs and exploit appropriate interventions for those with substance use disorders.
Optical and dielectric properties of polycrystalline gallium ferrite thin films on Pt/Si substrates
Authors: Mishra Monali , Swain Smrutirekha , Dash Sukalyan , Mukherjee Somdutta 
Published: December 2020

Abstract
In this work, GaFeO 3 thin films are deposited on Pt/Si substrates using sol-gel spin coating technique. The effect of these films on different properties such as: structural, optical and electrical properties are investigated. X- ray diffraction (XRD) confirms that GaFeO 3 has orthorhombic Pc2 1 n symmetry. Scanning electron microscopy reveals the uniform distribution of sol and crack free nature of the films. The optical absorption spectrum was recorded using DRS UV-Vis which showed the thin films are absorbed in the visible region. We have also performed experimentally which determines the flat band potential using Mott-Schottky equation. The width of the space charge region and charge carrier concentration of the thin films is also calculated. The dielectric properties of the thin films are also studied in this paper. This work opens up the possibility for the polycrystalline GaFeO 3 thin films to be used as phototelectrodes.
Comparative Outcomes in Patients Receiving Pirfenidone or Nintedanib for Idiopathic Pulmonary Fibrosis
Authors: Belhassen Manon , Dalon Faustine , Nolin Maëva , Ganse Eric Van 
Published: December 2020

Abstract
Background: Real-world data regarding outcomes of idiopathic pulmonary fibrosis (IPF) are scarce, outside of registries. In France, pirfenidone and nintedanib are only reimbursed for documented IPF, with similar reimbursement criteria with respect to disease characteristics, prescription through a dedicated form, and IPF diagnosis established in multidisciplinary discussion. Research question: The data of the comprehensive French National Health System were used to evaluate outcomes in patients newly treated with pirfenidone or nintedanib in 2015–2016. Study design and methods: Patients aged <50 years or who had pulmonary fibrosis secondary to an identified cause were excluded. All-cause mortality, acute respiratory-related hospitalisations and treatment discontinuations up to 31 December 2017 were compared using a Cox proportional hazards model adjusted for age, sex, year of treatment initiation, time to treatment initiation and proxies of disease severity identified during a pre-treatment period. Results: During the study period, a treatment with pirfenidone or nintedanib was newly initiated in 804 and 509 patients, respectively. No difference was found between groups for age, sex, time to treatment initiation, Charlson comorbidity score, and number of hospitalisations or medical contacts prior to treatment initiation. As compared to pirfenidone, nintedanib was associated with a greater risk of all-cause mortality (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.3–2.6), a greater risk of acute respiratory-related hospitalisations (HR, 1.3; 95% CI, 1.0–1.7) and a lower risk of treatment discontinuation at 12 months (HR, 0.7; 95% CI, 0.6–0.9).Interpretation: This observational study identified potential differences in outcome under newly prescribed antifibrotic drugs, deserving further explorations.
Network Pharmacology-based Study of Simiao Yongan Decoction for Treatment of Herpes Zoster Infection
Authors: Hongtao Liu , Guanyan Chen , Zhenhai Wu , Qiuqin Tang 
Published: December 2020

Abstract
Background: Herpes zoster (HZ) is a virus that causes infectious diseases that impact the quality of life of patients. Herein, we applied network pharmacological methods to predict the target of bioactive components in Simiao Yongan Decoction (SYD) that could treat HZ. Methods: We developed a Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMP) and GenneCards databases for screening of bioactive components of SYD, their targets, and HZ related targets. A bioactive component-target network of SYD was constructed using Cytoscape. We also constructed a protein-protein interaction (PPI) network using the Search Tool for the Retrieval of Interacting Genes Database (STRING) to identify potential SYD targets for the treatment of HZ. "ClusterProfiler" in R-project was used for Gene Ontology (GO) and KEGG pathway enrichment analyses. We screened SYD hub genes based on component-target network topological parameters and confirmed the findings by molecular docking. We selected 126 bioactive components and 235 targets. Results: By assessing the topological parameters of the degree network, we identified that CDK2, CASP3, JUN, AKT1, and MAPK1 were hub genes related to SYD-based therapy against HZ. The findings showed that treatment of HZ with SYD mainly involved toll-like receptor, C-type lectin receptor, MAPK, PI3K-Akt, and other signaling pathways. The molecular docking results revealed good binding energy between the SYD bioactive compounds and hub targets. Conclusion: We showed that SYD could effectively treat HZ via multiple targets and pathways. Our results provide theoretical support for treatment of HZ with SYD and a new direction for such treatment using traditional Chinese medicine.
Integrating the transcriptome and proteome to identify important functional genes for laying hens with hard- or weak-shelled eggs
Authors: Wu Yan , Pi Jinsong , Zhang Hao , Xiao Hongwei , Pan Ailuan , Shen Jie , Pu Yuejin , Liang Zhenhua , Du Jinping 
Published: December 2020

Abstract
Background

Eggshell strength and thickness are critical factors for reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality. Therefore, we employed transcriptional sequencing and proteomics to investigate the differences between the uteruses of laying hens with high- or low-breaking-strength shells.
Results

We identified 1028 differentially expressed genes (DEGs) and 270 differentially expressed proteins (DEPs). The analysis results of GO terms and KEGG pathways showed most of the DEGs and DEPs were enriched in vital pathways related to such processes as calcium metabolism, hormone and amino acid biosynthesis, and cell proliferation and apoptosis. Some DEGs and DEPs that were coexpressed at mRNA and protein levels were verified.
Conclusion

in summary, this study confirmed that during normal calcification, there are differences in ion transport between the uterus of hens producing high-breaking-strength and those producing low-breaking-strength eggshells, which may help to elucidate the eggshell calcification process.
Pulmonary Vasodilation by Sildenafil in Acute Intermediate-High Risk Pulmonary Embolism – A Randomized Explorative Trial
Authors: Andersen Asger , Waziri Farhad , Schultz Jacob Gammelgaard , Holmboe Sarah , Becker Søren Warberg , Jensen Tage , Søndergaard Hanne Maare , Dodt Karen Kaae , May Ole , Mortensen Ulrik Markus , Kim Won Yong , Mellemkjær Søren , Nielsen-Kudsk Jens Erik 
Published: December 2020

Abstract
Background: To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE). Methods: Single center, explorative trial. Patients with PE were randomized to a single oral dose of sildenafil 50mg (n=10) or placebo (n=10) as add-on to conventional therapy. The time from hospital admission to study inclusion was 2.3 ± 0.7 days. Right ventricular function was evaluated immediately before and shortly after (0.5-1.5h) randomization by right heart catheterization (RHC), trans-thoracic echocardiography (TTE), and cardiac magnetic resonance (CMR). The primary efficacy endpoint was cardiac index measured by CMR. Results: Patients had acute intermediate-high risk PE verified by computed tomography pulmonary angiography, systolic blood pressure of 135 ± 18 (mean ± SD) mmHg, increased right ventricular/left ventricular ratio 1.1 ± 0.09 and increased troponin T 167 ± 144 ng/L. Sildenafil treatment did not improve cardiac index compared to baseline (0.02 ± 0.36 l/min/m2, p=0.89) and neither did placebo (0.00 ± 0.34 l/min/m2, p=0.97). Conclusion: A single oral dose of sildenafil 50 mg did not improve cardiac index but lowered systemic blood pressure in patients with acute intermediate-high risk PE. The time from PE to intervention, a small patient sample size and low pulmonary vascular resistance are limitations of this study that should be considered when interpreting the results.
Sacral incidence to pubis: a novel and alternative morphologic radiological parameter to pelvic incidence in assessing spinopelvic sagittal alignment
Authors: Takahashi Yasuhito , Watanabe Kei , Okamoto Masashi , Hatsushikano Shun , Hasegawa Kazuhiro , Endo Naoto 
Published: December 2020

Abstract
Background: Although pelvic incidence (PI) is a key morphologic parameter in assessing spinopelvic sagittal alignment, accurate measurements of PI become difficult in patients with severe hip dislocation or femoral head deformities. This study aimed to investigate the reliability of our novel morphologic parameters and the correlations with established sagittal spinopelvic parameters.Methods: One hundred healthy volunteers (25 male and 75 female), with an average age of 38.9 years, were analysed. Whole-body alignment in the standing position was measured using a slot-scanning X-ray imager. We measured the established spinopelvic sagittal parameters and a novel parameter: the sacral incidence to pubis (SIP). The correlation coefficient of each parameter, regression equation of PI using SIP, and regression equation of lumbar lordosis (LL) using PI or SIP were obtained. The intraclass correlation coefficient (ICC) was calculated as an evaluation of the measurement reliability.Results: Reliability analysis showed high intra- and inter-rater agreements in all the spinopelvic parameters, with ICCs > 0.9. The SIP and pelvic inclination angle (PIA) demonstrated strong correlation with PI (R = 0.96) and pelvic tilt (PT) (R = 0.92). PI could be predicted according to the regression equation: PI = –9.92 + 0.905 * SIP (R = 0.9596, p < 0.0001). The ideal LL could be predicted using the following equation using PI and age: ideal LL = 32.33 + 0.623 * PI – 0.280 * age (R = 0.6033, p < 0.001) and using SIP and age: ideal LL = 24.29 + 0.609 * SIP – 0.309 * age (R = 0.6177, p < 0.001).Conclusion: Both SIP and PIA were reliable parameters for determining the morphology and orientation of the pelvis, respectively. Ideal LL was accurately predicted using the SIP with equal accuracy as the PI. Our findings will assist clinicians in the assessment of spinopelvic sagittal alignment.
Comprehensive analysis of miRNA-mRNA/lncRNA during gonadal development of triploid female rainbow trout (Oncorhynchus mykiss)
Authors: Huang Tianqing , Gu Wei , Liu Enhui , Shi Xiulan , Wang Bingqian , Xu Gefeng , Yao Zuochun 
Published: December 2020

Abstract
Background: Chromosomal ploidy manipulation is one of the means to create excellent germplasm. Triploid fish could provide an ideal sterile model for the mechanism research of abnormality in meiosis. The complete understanding of the coding and noncoding RNAs regulating sterility caused by meiosis abnormality is still not well understood.Results: By high-throughput sequencing, we compared the expression profiles of gonadal mRNA, long non-coding RNA (lncRNA), and microRNA (miRNA) at different developmental stages [65 days post fertilisation (dpf), 180 dpf, and 600 dpf] between the diploid (XX) and triploid (XXX) female rainbow trout. A majority of differentially expressed (DE) RNAs were identified, and 22 DE mRNAs related to oocyte meiosis and homologous recombination were characterized. The predicted miRNA-mRNA/lncRNA networks of 3 developmental stages were constructed based on the target pairs of DE lncRNA-miRNA and DE mRNA-miRNA. According to the networks, meiosis-related gene of ccne1 was targeted by dre-miR-15a-5p_R+1, and 6 targeted DE lncRNAs were identified. Also, RT-qPCR was performed to validate the credibility of the network.Conclusions: This study explored the potential interplay between coding and noncoding RNAs during the gonadal development of polyploid fish. It provides full insights into polyploidy-associated effects on fertility of fish. These differentially expressed coding and noncoding RNAs provide a novel resource for studying genome diversity of polyploid induction.
Lung ultrasound score assessing the pulmonary edema in pediatric acute respiratory distress syndrome received continuous hemofiltration therapy:&nbsp;A prospective observational study
Authors: Wang Fei , Wang Chunxia , Shi Jingyi , Shan Yijun , Miao Huijie , Sun Ting , Zhou Yiping , Zhang Yucai 
Published: December 2020

Abstract
Background: Lung ultrasound score is a potential method for determining pulmonary edema in acute respiratory distress syndrome (ARDS). Continuous renal replacement therapy (CRRT) has become the preferred modality to manage fluid overload during ARDS. The aim of this study was to evaluate the value of lung ultrasound (LUS) score on assessing the effects of CRRT on pulmonary edema and pulmonary function in pediatric ARDS. Methods: We conducted a prospective cohort study in 70 children with moderate to severe ARDS in a tertiary university pediatric intensive care unit from January 2016 to December 2019. 37 patients received CRRT (CRRT group) and 33 patients treated by conventional therapy (Non-CRRT group). LUS score was measured within 2 hours identified ARDS as the value of 1st，and the following three days as the 2nd, 3rd, and 4th. We used Spearman correlation analysis to develop the relationship between LUS score and parameters related to respiratory dynamics, clinical outcomes as well as daily fluid balance during the first four days after ARDS diagnosed.Results: The 1st LUS score in CRRT group were significantly higher than Non-CRRT group (P < 0.001), but the LUS score decreased gradually following CRRT (P < 0.001). LUS score was significantly correlated with Cdyn (1st: r =-0.757, 2nd: r =-0.906, 3rd: r =-0.885, 4th: r =-0.834), OI (1st: r =0.678, 2nd: r =0.689, 3rd: r =0.486, 4th: r =0.324) based on 1st to 4th values (all P <0.05). Only values of the 3rd and 4th LUS score after ARDS diagnosed were correlated with duration of mechanical ventilation [1st: r = 0.167, P = 0.325; 2nd: r = 0.299, P = 0.072; 3rd: r = 0.579, P < 0.001; 4th: r = 0.483, P = 0.002]. LUS score decreased from 22 (18 - 25) to 15 (13 - 18) and OI decreased from 15.92 (14.07 -17.73) to 9.49 (8.70-10.58) after CRRT for four days (both P < 0.001).Conclusions: LUS score is significantly correlated with lung function parameters in pediatric ARDS. The improvement of pulmonary edema in patient with ARDS received CRRT can be assessed by the LUS score.Trial registration: CCTR, ChiCTR-ONC-16009698. Registered 1 November 2016, prospectively registered, http://www.chictr.org.cn/edit.aspx?pid=16535&htm=4. This study adheres to CONSORT guidelines.
Fatigability is closely associated with discoordination between heart rate variability and physical acceleration during free-moving days in younger women
Authors: Taniguchi Kentaro , Shimouchi Akito , Jinno Naoya , Seiyama Akitoshi 
Published: December 2020

Abstract
Objects: Fatigability is related to several diseases and the autonomic nervous system. We investigated whether fatigability is associated with the coordination between the physical acceleration (PA) and heart rate variability (HRV) in women. Methods: Overall, 95 adult women were divided into younger group (n=50; age: 22–59 years) and older group (n=45; age: ≥ 60 years). HRV and PA data were simultaneously obtained every minute for 24 h. We defined %lag0 as the percent ratio of lag=0 min between HRV and PA in 1 h. Cornell Medical Index was used to determine the degrees of physical and psychological symptoms. Results: In the younger group in the hour before sleep, the participants with high fatigability scores had significantly lower (p<0.05) %lag0 than did those with low fatigability %lag0. Additionally, those with higher fatigability combined with exhaustion in the morning had significantly lower %lag0 than did those without exhaustion in the hour before sleep but not in the hour after waking up (p<0.05). Conclusions: These results suggest that the coordination between HRV and PA in younger women was closely associated with their fatigability in the hour before sleep. Additionally, exhaustion in the morning may be related to the discoordination of HRV and PA the previous night.
New view on the organization and evolution of Palaeognathae mitogenomes poses the question on the ancestral gene rearrangement in Aves
Authors: Urantowka Adam Dawid , Kroczak Aleksandra , Mackiewicz Pawel 
Published: December 2020

Abstract
BackgroundBird mitogenomes differ from other vertebrates in gene rearrangement. The most common avian gene order, identified first in Gallus gallus, is considered ancestral for all Aves. However, other rearrangements including a duplicated control region and neighboring genes have been reported in many representatives of avian orders. The repeated regions can be easily overlooked due to inappropriate DNA amplification or genome sequencing. This raises a question about the actual prevalence of mitogenomic duplications and the validity of the current view on the avian mitogenome evolution. In this context, Palaeognathae is especially interesting because is sister to all other living birds, i.e. Neognathae. So far, a unique duplicated region has been found in one palaeognath mitogenome, that of Eudromia elegans. ResultsTherefore, we applied an appropriate PCR strategy to look for omitted duplications in other palaeognaths. The analyses revealed the duplicated control regions with adjacent genes in Crypturellus, Rhea and Struthio as well as ND6 pseudogene in three moas. The copies are very similar and were subjected to concerted evolution. Mapping the presence and absence of duplication onto the Palaeognathae phylogeny indicates that the duplication was an ancestral state for this avian group. This feature was inherited by early diverged lineages and lost two times in others. Comparison of incongruent phylogenetic trees based on mitochondrial and nuclear sequences showed that two variants of mitogenomes could exist in the evolution of palaeognaths. Data collected for other avian mitogenomes revealed that the last common ancestor of all birds and early diverging lineages of Neoaves could also possess the mitogenomic duplication.ConclusionsThe duplicated control regions with adjacent genes are more common in avian mitochondrial genomes than it was previously thought. These two regions could increase effectiveness of replication and transcription as well as the number of replicating mitogenomes per organelle. In consequence, energy production by mitochondria may be also more efficient. However, further physiological and molecular analyses are necessary to assess the potential selective advantages of the mitogenome duplications.
Optimized sequential method assisting design and implementation of electro-pneumatic/hydraulic circuit
Authors: Marques Vinicius Abrão da Silva , Rodrigues Felipe Nascimento Cerqueira , Tavares José Jean-Paul Z. de S. 
Published: December 2020

Abstract
Electro-pneumatic circuits returned to be an important topic of research after the need of ventilator due COVID-19. Not only for this type of device but to assist economy restarting, the electro-pneumatic/hydraulic systems will be one of the industrial automation cornerstones after COVID pandemic. Programmable Logic Controllers (PLC) are one of the main components of these circuits and the standard of industrial automation; however, its application is highly dependent on programmers skills. Usually, electro-pneumatic/hydraulic solutions rely on sequential circuits. Different methods are found in the literature to design that systems, but they involve complex analyzes and intuitive strategies in cases that the actuators extend and retract more than once within the cycle of movements, and within simultaneous movements. As consequence, the resulting circuits mostly require a large number of valves and electronic components in order to be implemented. The objective of this work is to describe a novel method that can be applied in the design and implementation of optimized circuits using PLC's, eliminating intuitive solutions. Examples are presented to illustrate the theoretical procedures and experimental tests performed to validate the method. The results prove the generality of this work, the simplicity of its implementation, and introduce a bridge between design and implementation of electro-pneumatics and electro/hydraulics circuits with PLC's.