bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conditioned Pain Modulation Efficiency Is Associated With Pain Catastrophizing in Patients With Chronic Low Back Pain
Authors: Christensen Kasper S. , O’Sullivan Kieran , Palsson Thorvaldur S. 
Published: August 2020

Background:Previous studies have found a negative association between a conditioned pain modulation (CPM) response and pain catastrophizing among pain-free individuals. This study investigated the difference in CPM response between individuals with chronic low back pain (CLBP) and pain-free controls, and the association between pain catastrophizing and CPM response.Methods:In all, 22 individuals with CLBP and 22 sex-matched and age-matched controls underwent a CPM protocol. Pressure pain thresholds (PPTs) were measured on the lower leg and lower back. The CPM response was registered as the change in PPT from baseline to after a cold pressor test (CPT). Catastrophizing was assessed using the Pain Catastrophizing Scale before the CPM protocol in both groups.Results:Analysis of variance showed no interactions in PPT between groups and test sites at baseline or post-CPT. PPT increased significantly after CPT in the control group (P<0.006) but not in the CLBP group. The results showed significantly less pain inhibition participants with among participants with CLBP compared with controls (P<0.04). The CPM response was negatively associated with Pain Catastrophizing Scale scores in the CLBP group (rs=−0.67,P=0.0006) while no association was found in the control group.Discussion:This study demonstrated a reduced CPM response and a negative association between pain inhibition and pain catastrophizing in individuals with CLBP. The results suggest that catastrophizing thoughts are associated with the efficiency of descending endogenous pain modulation in CLBP, although a causal relationship cannot be inferred.
Surgical Management of Intramuscular Venous Malformations
Authors: Chen Reuben J. , Vrazas John I. , Penington Anthony J. 
Published: August 2020

Background:
Intramuscular venous malformations, often erroneously called “intramuscular hemangiomas,” present to pediatric orthopaedic surgeons either as a differential diagnosis of tumor or as a cause of muscle pain. Treatment options include injection sclerotherapy or surgery. There is some literature to indicate that sclerotherapy can reduce pain, but little evidence on the effectiveness of surgery. The primary aim of this study was to evaluate the efficacy of surgical resection for intramuscular venous malformations, with a secondary aim to evaluate the natural history and presentation of intramuscular venous malformations to improve clinician understanding of this condition.

Methods:
A retrospective chart analysis was performed of cases identified from a vascular anomalies database from January 2004 and December 2018. Primary outcome was change in preoperative and postoperative pain. Natural history of the lesion was assessed, including age when the lesion was first noticed, when it became painful, and when it required treatment.

Results:
Fifty-four cases were identified in the study period of which 40 underwent surgery. Pain improved in 36 of 39 patients (92.3%) who had pain before surgery and 29 (74.4%) were pain free after surgery. All 13 patients who required whole muscle excision to resect the lesion experienced an improvement in pain and 10 (76.9%) were pain free. A history of previous intervention, with surgery or sclerotherapy showed a trend towards less successful surgical outcomes. Patients presented across a wide age range from infancy to adulthood, but the most common presentation was pain with exercise between 9 and 16 years of age, with presence of a mass in about half of cases.

Conclusions:
Surgery, when performed by a surgeon with appropriate experience, is an effective first-line treatment for painful intramuscular venous malformations, offering pain relief in the majority of cases. Magnetic resonance imaging and ultrasound are diagnostic in most cases. The majority of lesions are resectable, meaning they can be removed with a margin leaving a functional limb. Sometimes resection of a whole muscle is required.

Level of Evidence:
Level IV—case series.
Clinical Outcomes in Critically Ill Coronavirus Disease 2019 Patients: A Unique New York City Public Hospital Experience
Authors: Mukherjee Vikramjit , Toth Alexander T. , Fenianos Madelin , Martell Sarah , Karpel Hannah C. , Postelnicu Radu , Bhatt Alok , Deshwal Himanshu , Kreiger-Benson Elana , Brill Kenneth , Goldlust Sandra , Nair Sunil , Walsh B. Corbett , Ellenberg David , Magda Gabriela , Pradhan Deepak , Uppal Amit , Hena Kerry , Chitkara Nishay , Alviar Carlos L. , Basavaraj Ashwin , Luoma Kelsey , Link Nathan , Bails Douglas , Addrizzo-Harris Doreen , Sterman Daniel H. 
Published: August 2020

Objectives:
To explore demographics, comorbidities, transfers, and mortality in critically ill patients with confirmed severe acute respiratory syndrome coronavirus 2.

Design:
Retrospective cohort study.

Setting:
Data were collected from a large tertiary care public hospital ICU that is part of the largest public healthcare network in the United States.

Patients:
One-hundred thirty-seven adult (≥ 18 yr old) ICU patients admitted between March 10, 2020, and April 7, 2020, with follow-up collected through May 18, 2020.

Interventions:
None.

Measurements:
Demographic, clinical, laboratory, treatment, and outcome data extracted from electronic medical records.

Main Results:
The majority of patients were male (99/137; 72.3%) and older than 50 years old (108/137; 78.9%). The most reported ethnicity and race were Hispanic (61/137; 44.5%) and Black (23/137; 16.7%). One-hundred six of 137 patients had at least one comorbidity (77.4%). One-hundred twenty-one of 137 (78.1%) required mechanical ventilation of whom 30 (24.8%) moved to tracheostomy and 46 of 137 (33.6%) required new onset renal replacement therapy. Eighty-two of 137 patients (59.9%) died after a median of 8 days (interquartile range 5–15 d) in the ICU. Male sex had a trend toward a higher hazard of death (hazard ratio, 2.1 [1.1–4.0]) in the multivariable Cox model.

Conclusions:
We report a mortality rate of 59.9% in a predominantly Hispanic and Black patient population. A significant association between comorbidities and mortality was not found in multivariable regression, and further research is needed to study factors that impact mortality in critical coronavirus disease 2019 patients. We also describe how a public hospital developed innovative approaches to safely manage a large volume of interhospital transfers and admitted patients.
Pharmacogenetic interactions of rifapentine plus isoniazid with efavirenz or nevirapine
Authors: Haas David W. , Podany Anthony T. , Bao Yajing , Swindells Susan , Chaisson Richard E. , Mwelase Noluthando , Supparatpinyo Khuanchai , Mohapi Lerato , Gupta Amita , Benson Constance A. , Baker Paxton , Fletcher Courtney V. 
Published: August 2020

Objectives
The effect of rifapentine plus isoniazid on efavirenz pharmacokinetics was characterized in AIDS Clinical Trials Group protocol A5279 (NCT01404312). The present analyses characterize pharmacogenetic interactions between these drugs, and with nevirapine.

Methods
A subset of HIV-positive individuals receiving efavirenz- or nevirapine-containing antiretroviral therapy in A5279 underwent pharmacokinetic evaluations at baseline, and again weeks 2 and 4 after initiating daily rifapentine plus isoniazid. Associations with polymorphisms relevant to efavirenz, nevirapine, isoniazid, and rifapentine pharmacokinetics were assessed.

Results
Of 128 participants, 101 were evaluable for associations with rifapentine and its active 25-desacetyl metabolite, 87 with efavirenz, and 38 with nevirapine. In multivariable analyses, NAT2 slow acetylators had greater week 4 plasma concentrations of rifapentine (P = 2.6 × 10−3) and 25-desacetyl rifapentine (P = 7.0 × 10−5) among all participants, and in efavirenz and nevirapine subgroups. NAT2 slow acetylators also had greater plasma efavirenz and nevirapine concentration increases from baseline to week 4, and greater decreases from baseline in clearance. CYP2B6 poor metabolizers had greater efavirenz concentrations at all weeks and greater nevirapine concentrations at baseline. None of 47 additional polymorphisms in 11 genes were significantly associated with pharmacokinetics.

Conclusions
Among HIV-positive individuals receiving efavirenz or nevirapine, and who then initiated rifapentine plus isoniazid in A5279, NAT2 slow acetylators had greater rifapentine and 25-desacetyl rifapentine concentrations, and greater increases from baseline in plasma efavirenz and nevirapine concentrations. These associations are likely mediated by greater isoniazid exposure in NAT2 slow acetylators.
Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian
Authors: Wu Peng-Bo , Qian Rao , Hong Chai , Guo Yi-tian , Yu Yuan-jie , Zhang Guo , Tan Shi-Yun 
Published: August 2020

Abstract

Background:
The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis.

Methods:
Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian.

Results:
Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian.

Conclusion:
This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.
Effect of sancai powder on glacemic variability of type 1 diabetes in China
Authors: Yu Weiwei , Zhou Dongqi , Zhang Li , Rumeng Chen , Zhang Peishuai , Sun Lisha , Gao Ziping 
Published: August 2020

Abstract

Background:
Type 1 diabetes mellitus (T1DM) is a chronic, immune-mediated disease characterized by the destruction of insulin producing cells and persistent hyperglycemia. At present, the drugs for type 1 diabetes mellitus can reduce blood glucose rapidly and effectively, but there are risks of hypoglycemia, large fluctuation of blood glucose, and chronic complications. Related research found that compared with continuous hyperglycemia, blood glucose fluctuations are more harmful to the chronic complications of diabetes. Blood glucose variation is closely related to the occurrence and development of chronic complications of diabetes. Sancai powder (SC) is made on the basis of 3 ancient Chinese medicine formulas, which has the effect of lowering blood glucose. There have been reports on the clinical study of SC in the treatment of diabetic patients, but there is no systematic evaluation of SC in the treatment of type 1 diabetes, so it is necessary to summarize and evaluate the existing evidence.

Methods and analysis:
This study will be conducted according to Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. We will search 3 English databases and 4 Chinese databases. Two methodologically trained researchers will read titles, abstracts, and full texts, and independently select eligible literature based on inclusion and exclusion criteria. After assessing the risk of bias and extracting data, we will conduct a meta-analysis of the results, including: standard deviation of blood glucose level, coefficient of variation, mean blood glucose, postprandial blood glucose fluctuation, hypoglycemia index, glycated hemoglobin, overall impact rate, and adverse effects. The heterogeneity of the data will be tested by Cochrane x2 and I2. Based on reliable subgroup effect guidance, we established 3 hypotheses for subgroup analysis: disease status at baseline, duration of intervention, and type of concomitant medication. Sensitivity analysis will be carried out to assess the stability of the results. The publication bias assessment will then be performed by funnel plot analysis and Egger test. Finally, we will use the “grading, evaluation, development and evaluation of recommendations” system to assess the quality of evidence.

Results:
The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.

Conclusion:
In our study, the evidence of SC in the treatment of reducing blood sugar fluctuation in type 1 diabetes will be comprehensively summarized and carefully evaluated. It will provide more options for clinical treatment of the disease.

INPLASY registration number:
INPLASY202050052
Re-evaluation of the criteria for asymmetric amplatzer occluders in the closure of perimembranous ventricular septal defects
Authors: Li Gang , Liao Hongyu , Wu Jinlin , Zhou Kaiyu , Hua Yimin , Wang Chuan , Duan Hongyu , Shi Xiaoqing , Wu Gang , Li Yifei 
Published: August 2020

Abstract

Rationale:
To discuss suitable criteria for the application of asymmetric Amplatzer occluders for perimembranous ventricular septal defects (pmVSDs).

Patients concerns and diagnoses:
We retrospectively studied 18 children with perimembranous VSDs who underwent attempted asymmetric occluder closure between January 2015 and December 2018 in our center.

Interventions:
Asymmetric Amplatzer occluders were attempted to be placed to all the enrolled patients. We analyzed the diameter of the defects with the receiver operating characteristic curve (ROC) values, the size of the occluders attempted, the presence of aneurysm and the presence of aortic valve prolapse for each patient. Then, for patients who experienced successful device implantation, the therapeutic efficiency was evaluated by follow-up.

Outcomes:
Only 5 out of a total of 18 patients completed successful device implantation. Compared with failed cases, successful cases demonstrated a significantly smaller VSD size (5.46 ± 1.03 mm vs. 8.73 ± 2.33 mm, P = 0.012) and had a low ratio of aortic valvar prolapse (20% vs. 76.92%, P = 0.026). Four out of 5 successful cases involved arrhythmia complications, but the rhythm of the heart recovered after drug treatment. According to the ROC and Youden analyses, the cut-off value of the defect size for successful asymmetric Amplatzer occluder implantation was no larger than 5.7 mm.

Lessons:
The application of an asymmetric Amplatzer occluder expands the range of indications for patients with superior localized VSD but is largely limited in cases with aortic valvar prolapse and large VSD sizes. All successful cases recovered from arrhythmia postprocedure.
Red cell distribution width to platelet ratio predicts liver fibrosis in patients with autoimmune hepatitis
Authors: Wang Huali , Wang Jian , Xia Juan , Yan Xiaomin , Feng Yanhong , Li Lin , Chen Jun , Liu Duxian , Ding Weimao , Yang Yongfeng , Huang Rui , Wu Chao 
Published: August 2020

Abstract
Noninvasive tests for the assessment of liver fibrosis are highly needed for the management of patients with autoimmune hepatitis (AIH). We aimed to investigate the accuracy of red cell distribution width to platelet ratio (RPR) in predicting liver fibrosis in AIH patients. One hundred nineteen AIH patients who underwent liver biopsy were enrolled. Liver fibrosis stage was diagnosed using the Scheuer scoring system. The diagnostic accuracy was evaluated by the area under the receiver operating characteristic curve (AUROC). RPR values in AIH patients with S2-S4 (0.10, interquartile range [IQR] 0.08–0.15), S3-S4 (0.10, IQR 0.09–0.14), and S4 (0.14, IQR 0.09–0.19) were significantly higher than patients with S0-S1 (0.07, IQR 0.06–0.08, P < .001), S0-S2 (0.08, IQR 0.06–0.12, P = .025) and S0-S3 (0.09, IQR 0.07–0.13, P = .014), respectively. The RPR was positively correlated with fibrosis stages (r = 0.412, P < .001), while aspartate transaminase to platelet ratio index (APRI) and fibrosis-4 score (FIB-4) were not significantly associated with fibrosis stages in AIH patients. The AUROCs of RPR in identifying significant fibrosis (S2-S4), advanced fibrosis (S3-S4), and cirrhosis (S4) were 0.780 (95% confidence interval [CI] 0.696–0.865), 0.639 (95% CI 0.530–0.748), and 0.724 (95% CI 0.570–0.878), respectively. The AUROCs of RPR were significantly higher than APRI and FIB-4 in diagnosing significant fibrosis, advanced fibrosis, and cirrhosis. Our study demonstrates that the RPR is a simple predictor of liver fibrosis and is superior to APRI and FIB-4 in identifying liver fibrosis in AIH patients.
Effect of polyglycolic acid mesh for prevention of pancreatic fistula after pancreatectomy
Authors: Zhang Wei , Wei Zhicheng , Che Xu 
Published: August 2020

Abstract
Postoperative pancreatic fistula (POPF) is the most common and intractable complication after partial pancreatectomy, with an incidence of 13% to 64%. Polyglycolic acid (PGA) mesh is a new technique that is designed to prevent POPF, and its effect has been evaluated in several randomized controlled trials and some retrospective cohort studies. In this study, we systematically and comprehensively analyzed the efficacy of PGA mesh based on reported studies.
We searched Medline, Embase, and Cochrane Library databases in English between January 2010 and October 2019. Analysis was performed by using Review Manger 5.3 software.
Three RCTs and 8 nonrandomized studies were eligible with a total of 1598 patients including 884 PGA group patients and 714 control group patients. For pancreatoduodenectomy (PD), distal pancreatectomy (DP), and the 2 partial pancreatectomy (PD or DP), we found significant statistical differences in overall POPF (relative risk [RR] = 0.75, 95% confidence interval [CI] = 0.61–0.91, P = .004; RR = 0.74, 95% CI = 0.57–0.96, P = .02; RR = 0.76, 95% CI = 0.64–0.89, P = .0009, respectively) and clinical pancreatic fistula (PF) (RR = 0.5, 95% CI = 0.37–0.68, P < .00001; RR = 0.31, 95% CI = 0.21–0.46, P
< .00001; RR = 0.41, 95% CI = 0.32–0.52, P < .00001, respectively) in favor of PGA. For partial pancreatectomy, significant statistical differences were found in overall complications (RR = 0.77, 95% CI: 0.67–0.88, P = .0002) and estimated blood loss (weighted mean difference [WMD] = −53.58; 95% CI: −101.20 to −5.97, P = .03) in favor of PGA. We did not find significant differences regarding operative time (WMD = −8.86; 95% CI: −27.59 to 9.87, P = .35) and hospital stay (WMD = −2.73; 95% CI: −7.53 to 2.06, P = .26).
This meta-analysis shows the benefits of the PGA mesh technique regarding POPF, clinical PF, and postoperative complications. This still needs to be verified by more randomized control trials.
Effects of bariatric surgery in Chinese with obesity and type 2 diabetes mellitus
Authors: Zuo Didi , Xiao Xianchao , Yang Shuo , Gao Yuan , Wang Guixia , Ning Guang 
Published: August 2020

Abstract
The incidence of obesity and type 2 diabetes mellitus is growing, and bariatric surgery was applied as a new therapy in the past few decades. However, bariatric surgery started rather late in China, and the number of surgeries and the follow-up data is limited.
We assessed body weight, glucose, lipid levels, and blood pressure at baseline and 6-month, 1-year, 3-year in patients who underwent bariatric surgery. Vitamins and trace elements were investigated at 3-year after surgery. The quality of life was assessed at 3-year and compared with the control group.
In total 20 patients were recruited in the study, and all the 20 patients underwent surgery and completed all follow-ups. Results showed that the body weight, body mass index, glycated hemoglobin (HbA1C), glucose, and insulin level were decreased, and islet function improved significantly in 6-month and 1-year (P < .001), and the changes were more obvious in the first 6 months. However, all the indexes rebound significantly at the 3-year (P < .05), but still better than baseline (P < .05). Weight regain was 50% after 3 years, and the mean weight regain rate was 31.45%. Besides, blood pressure and lipid levels decreased significantly compared with baseline (P < .001). At the 3-year follow-up, we found that 100% of the patients showed vitamin D deficiency, 50% calcium deficiency, 20% vitamin B12 deficiency, 20% iron deficiency, and 15% suffered from anemia. Compared with the control group, the quality of life was better in patients who underwent surgery, especially in the physical health (P < .05).
The current study showed that the body weight, glucose and islet function improved significantly after bariatric surgery, and the indexes changed mainly in the first 6 months, but there seemed to be a rebound after 3 years. Furthermore, the surgery may improve the blood pressure, lipid profile, and the quality of life. However, some patients may suffer anemia, calcium deficiency, iron deficiency, vitamin D, and vitamin B12 deficiency after 3 years.
The impact of intense nursing care in improving anxiety, depression, and quality of life in patients with liver cancer
Authors: Zhang Qiao , Wan Rong , Liu Changdan 
Published: August 2020

Abstract

Background:
Liver resection is a major, serious, and very delicate operation that should be done only by specialized, well-skilled, and experienced surgeons. However, the role of nurses, which has often been under-estimated, is also crucial for the success of the intervention or surgery. Intensive nursing care involves high quality nursing modes to achieve the expected goals of treatment smoothly and with less complications. In this analysis, we aimed to show the impact of intense nursing care in improving anxiety, depression, and quality of life in patients with intervention for liver cancers.

Methods:
Data sources included EMBASE, MEDLINE, Web of Science, the Cochrane central, Google scholar, and http://www.ClinicalTrials.gov. Three authors independently extracted data from the selected original studies. The statistical analysis was carried out by the Cochrane based RevMan software. For dichotomous data, the number of events and the total number of participants were required and for the continuous data, mean, standard deviation as well as the total number of participants were required in the input for analysis. Odds ratios (OR) with 95% confidence intervals (CI) were used to represent the data following assessment.

Results:
A total of 1205 participants with liver cancer enrolled between the years 2010 to 2018 were included in this analysis whereby 667 participants were assigned to an intensive nursing care. Our current analysis showed that most of the patients who were assigned to an intense nursing intervention were significantly very satisfied with their quality of life (OR: 4.07, 95% CI: 1.45 – 11.45; P = .008). However, a minor number of patients with liver cancer who were not assigned to intense nursing care were significantly dissatisfied with their quality of life with OR: 0.18, 95% CI: 0.04 – 0.77; P = .02. This analysis also showed that self-rating anxiety score (SAS) and self-rating depression score (SDS) were significantly in favor of the participants with intense nursing care with OR: − 7.66, 95% CI: [(−9.66) – (−5.66)]; P = .00001 and OR: −7.87, 95% CI: [(−8.43) – (−7.26)]; P = .00001 respectively. In addition, physical function (OR: 13.56, 95% CI: 12.39 – 14.74; P = .00001), and total activity score (OR: 16.58, 95% CI: 13.51 – 19.65; P = .00001) were also significantly in favor of an intense nursing care.

Conclusions:
Our current analysis showed that intense nursing care significantly improved anxiety, depression, and quality of life following interventions in patients with liver cancers. Most of the patients with liver cancers who were assigned to an intense nursing care were very satisfied with their quality of life. However, this hypothesis should further be confirmed in larger nursing related studies based on patients with liver cancers.