bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain: A Randomized Double-Blind Clinical Trial
Authors: Dadabayev Alisher R. , Joshi Sonalee A. , Reda Mariam H. , Lake Tamar , Hausman Mark S. , Domino Edward , Liberzon Israel 
Published: December 2020

Objective To date, treatment options (i.e. psychotherapy, antidepressant medications) for patients with posttraumatic stress disorder (PTSD), are relatively few, and considering their limited efficacy, novel therapies have gained interest among researchers and treatment providers alike. Among patients with chronic pain (CP) about one third experience comorbid PTSD, which further complicates their already challenging pharmacological regimens. Low dose ketamine infusion has shown promise in PTSD, and in treatment of CP, however they have not been studied in comorbid population and under rigorous control conditions. Methods We compared the effects of a single dose of either ketamine (0.5 mg/kg) or ketorolac (15 mg) over a 40-minute of IV infusion in CP patients with and without PTSD, in double blind, randomized study. Measures were collected before, during, one day and seven days after the infusion. A planned sample size of 40 patients randomly assigned to treatment order was estimated to provide 80% power to detect a hypothesized treatment difference after the infusion. Main Outcome and Measures: The primary outcome measures were change in PTSD symptom severity assessed with the Impact of Event Scale–Revised (IES-R) and Visual Analogue Scale (VAS) for pain administered by a study clinician 24 hours post infusion. Secondary outcome measures included Impact of Event Scale–Revised (IES-R), VAS and Brief Pain Inventory (Short Form) for pain 1 week after the infusion. Results Both treatments offered comparable improvement of PTSD and CP symptoms that persisted for 7 days after the infusion. Patients with comorbid PTSD and CP experienced less dissociative side effects compared to the CP group. Surprisingly, ketorolac infusion resulted in dissociative symptoms in CP patients only. Conclusions This first prospective study comparing effects of subanesthetic ketamine versus ketorolac infusions for comorbid PTSD and CP, suggests that both ketamine and ketorolac might offer meaningful and durable response for both PTSD and CP symptoms.
How to adapt caring services to migration-driven diversity? A qualitative study exploring challenges and possible adjustments in the care of people living with dementia
Authors: Sagbakken Mette , Ingebretsen Reidun , Spilker Ragnhild Storstein 
Published: December 2020

Background
Research on how services can be adapted to meet the needs of people with dementia with an immigrant or minority ethnic background is scarce. Several approaches have been discussed: offering services adapted to language and culture, adding bilingual staff to mainstream services, and providing cultural awareness and sensitivity training to health personnel in mainstream services. This study seeks to develop more knowledge of challenges and possible adjustments related to receive and provide public care for people living with dementia with an immigrant or minority ethnic background.

Methods and materials
Through a qualitative design, including 19 single interviews, 3 dyad interviews and 16 focus groups with older immigrants, relatives of immigrants with dementia, and health personnel, we explored experiences and perceptions related to receive and provide care for people with immigrant backgrounds living with dementia in Norway. The analysis were conducted inspired by Kvale and Brinkmann’s three contexts of interpretations.

Results
Challenges related to language and communication were emphasized as the most fundamental barrier to provide adjusted care; exemplified through cases of isolation and agitation among patients not able to communicate. Care services framed by the majority culture creates feelings of alienation and exclusion. Not having access to specific types of food and the possibility to listen to songs, music, literature or TV programs representing a familiar and homely context may prevent use of public dementia care. Findings also point to differences in moral views regarding life-prolonging treatment in advanced stages of dementia.

Conclusion
This study argues that to be able to address challenges related to migration-driven diversity one needs holistic care services that addresses individual as well as socio-cultural needs. A linguistically and culturally diverse workforce may represent an important resource, potentially reducing some of the problems related to communication. On a structural level, it seems necessary to allocate more time and resources, including the use of interpreters, when assessing and getting to know persons with dementia with another linguistic and cultural background. However, shared language does not guarantee understanding. Rather, one needs to become familiar with each person’s way of being ill, on a cultural and individual level, including changes occurring living with progressive dementia. Getting to know a person and his/her family will also facilitate the possibility to ensure a more familiar and homely context. Thus, continuity in relation to language and culture is important, but continuity in relations may be equally important ensuring that people with dementia receive equitable care.
Finding the Local in Islamicate History Writing in India (1200–1400 CE)
Authors: Auer Blain 
Published: December 2020

Abstract
This paper discusses the idea of the “local” as it applies to Persian history writing across the thirteenth and fourteenth centuries and produced in South Asia. Geographers ordered land and space with the concepts of climes (s. iqlīm) and regions (kishvar) which reflected different peoples and climates. Historians more generally related geography to power, and kingdoms (s. mamlakat) served as the primary geographical framework. How did imperial ideologies formulated in thirteenth and fourteenth-century Islamic courts define India through geographical and historical concepts? Does the idea of the “local” exist as a conceptual idea in history writing? This paper is concerned to understand how historical knowledge was used in this political context to define the localities and regions of India in relation to Delhi and other Islamic courts of India.
Development of Smartphone-Controlled Hand and Arm Exoskeleton for Persons with Disability
Authors: Diego J-R. R. , Martinez Dan William C. , Robles Gerald S. , Dizon John Ryan C. 
Published: December 2020

Abstract
This study addresses the need for assistive technology of people who lost control of their upper limbs as well as people who are undergoing rehabilitation. Loss of upper limb control causes lack of functionality and social acceptability especially for many people in developing countries with fewer available technology. The study develops a modern but low-cost prosthetic device that can be controlled by users using a smartphone and can be rapidly manufactured using three-dimensional printing (3D printing) of plastic materials. The development of the prosthetic device includes designing the mechanical and electronic parts, programming the Arduino board and Android application for control, simulation and analysis of 3D printed parts most subjected to stress, and 3D printing the parts under different settings. The device was tested in terms of time spent and capacity of lifting varying loads when not worn and when worn by users. The device can effectively lift 500 grams of load in one second for a person weighing between 50 to 60 kilograms.
Evaluation of audio-voice guided application for neonatal resuscitation: a prospective, randomized, pilot study
Authors: Dinur Gil , Borenstein-Levin Liron , Vider Shachar , Hochwald Ori , Jubran Huda , Littner Yoav , Fleischer-Sheffer Vered , Kugelman Amir 
Published: December 2020

Abstract

Objectives
To examine whether audio-voice guidance application improves adherence to resuscitation sequence and recommended time frames during neonatal resuscitation.

Methods
A prospective, randomized, pilot study examining the use of an audio-voice application for guiding resuscitation on newborn mannequins, based on the Neonatal Resuscitation Program (NRP) algorithm. Two different scenarios, with and without voice guidance, were presented to 20 medical personnel (2 midwives, 8 nurses, and 10 physicians) in random order, and their performance videotaped.

Results
Audio-voice guided resuscitation compared with non-guided resuscitation, resulted in significantly better compliance with NRP order sequence (p<0.01), correct use of oxygen supplementation (p<0.01) and performance of MR SOPA (Mask, reposition, suction, open mouth, pressure, airway) (p<0.01), and shortened the time to “positive pressure ventilation” (p<0.01).

Conclusions
In this pilot study, audio-voice guidance application for newborn resuscitation simulation on mannequins, based on the NRP algorithm, improved adherence and performance of NRP guidelines.
THz spintronic emitters: a review on achievements and future challenges
Authors: Papaioannou Evangelos Th. , Beigang René 
Published: December 2020

Abstract
The field of THz spintronics is a novel direction in the research field of nanomagnetism and spintronics that combines magnetism with optical physics and ultrafast photonics. The experimental scheme of the field involves the use of femtosecond laser pulses to trigger ultrafast spin and charge dynamics in thin films composed of ferromagnetic and nonmagnetic thin layers, where the nonmagnetic layer features a strong spin–orbit coupling. The technological and scientific key challenges of THz spintronic emitters are to increase their intensity and to shape the frequency bandwidth. To achieve the control of the source of the radiation, namely the transport of the ultrafast spin current is required. In this review, we address the generation, detection, efficiency and the future perspectives of THz emitters. We present the state-of-the-art of efficient emission in terms of materials, geometrical stack, interface quality and patterning. The impressive so far results hold the promise for new generation of THz physics based on spintronic emitters.
Structure, morphology, size and application of iron phosphate
Authors: Zhang Xiaoxing , Zhang Li , Liu Hui , Cao Binxia , Liu Libo , Gong Weimin 
Published: December 2020

AbstractIron phosphates have rich chemical structures with various morphologies and sizes. Since they are environment friendly with good biocompatibility, they have good performances in the fields of catalysis and battery electrode material rising in recent years, as well as in the traditional fields like agriculture and steel. They also have important applications in adsorption, separation and concentration due to their unique structural characteristics. In this paper, iron phosphates are classified based on their common characteristics such as structure, morphology and size, and their application in the past two decades is reviewed, with emphasis on their application in adsorption, separation and concentration of different species. Further, their application in adsorption, separation and concentration of heavy metals is prospected.
Tenure Status, Housing Conditions and Residential Satisfaction of Adolescents
Authors: Matel Anna 
Published: December 2020

Abstract
The paper aims to investigate factors connected with the residential satisfaction of the adolescents and to compare them with the factors influencing residential satisfaction among adults. The primary research was conducted in secondary schools in the Bialystok Functional Area. The data was analyzed using descriptive statistics and a multinomial logistic regression model. The results show that living standards are a crucial issue in residential satisfaction. Living in an owner-occupied dwelling and having one’s own room reduced the likelihood of being dissatisfied with housing.
Pesticide applicators and cancer: a systematic review
Authors: Varghese Jean V. , Sebastian Elveena M. , Iqbal Thamanna , Tom Antriya A. 
Published: December 2020

Abstract
The objective of the study was to identify and analyse the research done on the occurrence of cancer among pesticide applicators by conducting a systematic review of the scientific literature. PRISMA Guidelines was followed to conduct the study. Search was done in Scopus, PubMed, Embase, MEDLINE and Google Scholar databases with search terms “PESTICIDE APPLICATORS”, “CANCER” using Boolean operator “AND”. Meta-analysis and review articles were excluded from the study. A total of 32 studies were identified among which the average sample size was found to be 60,521. Increased RRs/ORs and positive exposure–response relationships were observed for 31 pesticides. Organophosphate and organochlorine classes of pesticides were the most to be associated with cancer. Lung cancer was observed the most followed by prostate, multiple myeloma and colon cancers among pesticide applicators. It was concluded that there is an increased risk of cancer among the pesticide applicators, whereby which bringing into focus the need to educate and train the workers on following adequate safety measures and making them aware of the hazardous chemicals. Further evaluation on the carcinogenicity of pesticides is also required.
Synergetic metronidazole removal from aqueous solutions using combination of electro-persulfate process with magnetic Fe3O4@AC nanocomposites: nonlinear fitting of isotherms and kinetic models
Authors: Malakootian Mohammad , Aghasi Majid , Fatehizadeh Ali , Ahmadian Mohammad 
Published: December 2020

Abstract
The removal of metronidazole (MNZ) from aqueous solutions by the electro-persulfate (EC–PS) process was performed in combination with magnetic Fe3O4@activated carbon (AC) nanocomposite. In the first step, the Fe3O4@AC nanocomposites were synthesized and characterized using energy-dispersive X-ray spectroscopy (XRD), vibrating-sample magnetometer (VSM) and field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), mapping, and Fourier-transform infrared spectroscopy (FTIR) analysis. The effect of Fe3O4@AC, PS and EC processes were studied separately and in combination and finally, the appropriate process for MNZ removal was selected. The effect of key parameters on the EC–Fe3O4@AC–PS process including pH, Fe3O4@AC dosage, initial MNZ concentration, and PS concentration were investigated. Based on the results obtained, the Fe3O4@AC had a good structure. The MNZ removal in EC, PS, Fe3O4@AC, EC–Fe3O4@AC, EC–PS, EC–Fe3O4@AC–NaCl, EC–Fe3O4@AC–PS, and EC–Fe3O4@AC–PS–NaCl processes were 0, 0, 59.68, 62, 68.94, 67.71, 87.23 and 88%, respectively. Due to the low effect of NaCl insertion on the EC–Fe3O4@AC–PS process, it was not added into the reactor and optimum conditions for the EC–Fe3O4@AC–PS process were determined. Under ideal conditions, including MNZ = 40 mg/L, Fe3O4@AC dose = 1 g/L, pH = 3, PS concentration = 1.68 mM, current density (CD) = 0.6 mA/cm2 and time = 80 min, the MNZ removal was 92%. Kinetic study showed that the pseudo-second-order model was compatible with the obtained results. In the isotherm studies, the Langmuir model was the most consistent for the data of the present study, and the Q
max for Fe3O4@AC dose from 0.25 to 1 g/L was 332 to 125 mg/g, respectively.
Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials
Authors: Sano Motoaki , Tamura Tomoyoshi 
Published: December 2020

Background:
Mounting evidence indicates that hydrogen gas (H2) is a versatile therapeutic agent,
even at very low, non-combustible concentrations. The Chinese National Health and Medical Commission recently
recommended the use of inhaled H2 in addition to O2 therapy in the treatment of COVID-19-associated
pneumonia, and its effects extend to anti-tumor, anti-inflammatory and antioxidant actions.

Summary:
In this review, we highlight key findings from preclinical researchn this review, we have highlighted key findings from preclinical research and recent clinical studies
demonstrating that H2 reduces the organ damage caused by ischemia-reperfusion. We have also outlined the
critical role this effect plays in a variety of medical emergencies, including myocardial infarction, hemorrhagic
shock, and out-of-hospital cardiac arrest, as well as in organ transplantation. H2 is compared with established
treatments such as targeted temperature management, and we have also discussed its possible mechanisms of
action, including the recently identified suppression of TNF-α-mediated endothelial glycocalyx degradation by
inhaled H2. In addition, our new method that enables H2 gas to be easily transported to emergency settings and
quickly injected into an organ preservation solution at the site of donor organ procurement have been described. and recent clinical studies demonstrating
that H2
reduces the organ damage caused by ischemia–reperfusion. We outline the critical role this effect plays in a variety
of medical emergencies, including myocardial infarction, hemorrhagic shock, and out-of-hospital cardiac arrest, as well as
in organ transplantation. H2
is compared with established treatments such as targeted temperature management, and we
discuss its possible mechanisms of action, including the recently identified suppression of TNF-α-mediated endothelial
glycocalyx degradation by inhaled H2
. In addition, we describe our new method that enables H2 gas to be easily
transported to emergency settings and quickly injected into an organ preservation solution at the site of donor organ
procurement.

Conclusion:
H2 is an easily administered, inexpensive and well-tolerated agent that is highly effective for a
wide range of conditions in emergency medicine, as well as for preserving donated organs.
Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis
Authors: Assimon Magdalene M. , Flythe Jennifer E. 
Published: December 2020

Background and objectives
Zolpidem, a nonbenzodiazepine hypnotic, and trazodone, a sedating antidepressant, are the most common medications used to treat insomnia in the United States. Both drugs have side effect profiles (e.g., drowsiness, dizziness, and cognitive and motor impairment) that can heighten the risk of falls and fractures. Despite widespread zolpidem and trazodone use, little is known about the comparative safety of these medications in patients receiving hemodialysis, a vulnerable population with an exceedingly high fracture rate.

Design, setting, participants, & measurements
Using data from the United States Renal Data System registry (2013–2016), we conducted a retrospective cohort study to investigate the association between the initiation of zolpidem versus trazodone therapy and the 30-day risk of hospitalized fall-related fractures among Medicare-enrolled patients receiving maintenance hemodialysis. We used an active comparator new-user design and estimated 30-day inverse probability of treatment-weighted hazard ratios and risk differences. We treated death as a competing event.

Results
A total of 31,055 patients were included: 18,941 zolpidem initiators (61%) and 12,114 trazodone initiators (39%). During the 30-day follow-up period, 101 fall-related fractures occurred. Zolpidem versus trazodone initiation was associated with a higher risk of hospitalized fall-related fracture (weighted hazard ratio, 1.71; 95% confidence interval, 1.11 to 2.63; weighted risk difference, 0.17%; 95% confidence interval, 0.07% to 0.29%). This association was more pronounced among individuals prescribed higher zolpidem doses (hazard ratio, 1.85; 95% confidence interval, 1.10 to 3.01; and risk difference, 0.20%; 95% confidence interval, 0.04% to 0.38% for higher-dose zolpidem versus trazodone; and hazard ratio, 1.60; 95% confidence interval, 1.01 to 2.55 and risk difference, 0.14%; 95% confidence interval, 0.03% to 0.27% for lower-dose zolpidem versus trazodone). Sensitivity analyses using longer follow-up durations yielded similar results.

Conclusions
Among individuals receiving maintenance hemodialysis, zolpidem initiators had a higher risk of hospitalized fall-related fracture compared with trazodone initiators.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_12_18_CJN10070620_final.mp3
The Mobile Health Readiness of People Receiving In-Center Hemodialysis and Home Dialysis
Authors: Hussein Wael F. , Bennett Paul N. , Pace Sloane , Chen Shijie , Legg Veronica , Atwal Jugjeet , Sun Sumi , Schiller Brigitte 
Published: December 2020

Background and objectives
Mobile health is the health care use of mobile devices, such as smartphones. Mobile health readiness is a prerequisite to successful implementation of mobile health programs. The aim of this study was to examine the status and correlates of mobile health readiness among individuals on dialysis.

Design, setting, participants, & measurements
A cross-sectional 30-item questionnaire guided by the Khatun mobile health readiness conceptual model was distributed to individuals on dialysis from 21 in-center hemodialysis facilities and 14 home dialysis centers. The survey assessed the availability of devices and the internet, proficiency, and interest in using mobile health.

Results
In total, 949 patients (632 hemodialysis and 317 home dialysis) completed the survey. Of those, 81% owned smartphones or other internet-capable devices, and 72% reported using the internet. The majority (70%) reported intermediate or advanced mobile health proficiency. The main reasons for using mobile health were appointments (56%), communication with health care personnel (56%), and laboratory results (55%). The main reported concerns with mobile health were privacy and security (18%). Mobile health proficiency was lower in older patients: compared with the 45- to 60-years group, respondents in age groups <45, 61–70, and >70 years had adjusted odds ratios of 5.04 (95% confidence interval, 2.23 to 11.38), 0.39 (95% confidence interval, 0.24 to 0.62), and 0.22 (95% confidence interval, 0.14 to 0.35), respectively. Proficiency was lower in participants with Hispanic/Latinx ethnicity (adjusted odds ratio, 0.49; 95% confidence interval, 0.31 to 0.75) and with less than college education (adjusted odds ratio for “below high school,” 0.09; 95% confidence interval, 0.05 to 0.16 and adjusted odds ratio for “high school only,” 0.26; 95% confidence interval, 0.18 to 0.39). Employment was associated with higher proficiency (adjusted odds ratio, 2.26; 95% confidence interval, 1.18 to 4.32). Although home dialysis was associated with higher proficiency in the unadjusted analyses, we did not observe this association after adjustment for other factors.

Conclusions
The majority of patients on dialysis surveyed were ready for, and proficient in, mobile health.

Clinical Trial registry name and registration number: Dialysis mHealth Survey,
NCT04177277
Generalized Fractional Inequalities of the Hermite–Hadamard Type for Convex Stochastic Processes
Authors: Omaba McSylvester Ejighikeme , Nwaeze Eze R. 
Published: December 2020

Abstract
A generalization of the Hermite–Hadamard (HH) inequality for a positive convex stochastic process, by means of a newly proposed fractional integral operator, is hereby established. Results involving the Riemann– Liouville, Hadamard, Erdélyi–Kober, Katugampola, Weyl and Liouville fractional integrals are deduced as particular cases of our main result. In addition, we also apply some known HH results to obtain some estimates for the expectations of integrals of convex and p-convex stochastic processes. As a side note, we also pointed out a mistake in the main result of the paper [Hermite–Hadamard type inequalities, convex stochastic processes and Katugampola fractional integral, Revista Integración, temas de matemáticas 36 (2018), no. 2, 133–149]. We anticipate that the idea employed herein will inspire further research in this direction.