bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds
Authors: Monteiro F. S. , Carvalho A. F. S. , Ribeiro R. M. , Borges A. C. R. , Borges M. O. R. 
Published: March 2020

Aims: Perform the phytochemical analysis and investigate the spasmolytic activity of the hydroalcoholic extract obtained from S. cumini seeds (EHS-SC).
Study Design: Qualitative phytochemical analysis and test of the EHS-SC on isolated smooth muscles (aorta, trachea, jejunum and uterus) of rat, to value effect relaxant and/or inhibitor.
Place and Duration of Study: Pharmacognosy Laboratory II (Pharmacy course) and Pharmacology Research and Post-Graduate Laboratory (Department of Physiological Sciences) of the Federal University of Maranhão, between January 2017 and July 2018.
Methodology: EHS-SC was submitted to phytochemical analysis and changes in color, fluorescence and absence or presence of precipitate were observed. The smooth muscle segments were suspended (tension of 1 g) in glass vats containing specific saline solution, at an appropriate temperature and after stabilization period, was stimulated by a suitable contractile agent to observe the effect of EHS-SC in the phasic and/or tonic component.
Results: EHS-SC showed the majority presence of phenols, steroids, alkaloids and flavonoids (flavones, xanthones, flavonols) and was more potent in inhibiting phasic contractions induced by 10-6 M carbachol (CCh) in isolated rat jejunum (Emax: 83.5 ± 6.7%; n = 3). In addition, the EHS-SC (81.0; 243.0 and 729 µg/mL) antagonized the CCh effect (n = 4), increasing the EC50 (6.5 ± 1.3 x 10-7 M) of the CCh to 8.5 ± 1.1; 18.5 ± 3.4 and 40.5 ± 7.4 x 10-7 M and reducing the Emax (100%) of the CCh to 82.9 ± 10.5; 67.6 ± 6.0 and 10.1 ± 8.3%.
Conclusion: Spasmolytic activity may be combined with antimicrobial and antidiarrheal activity according to literature data, where they show that the seeds have the same secondary metabolites, signaling the therapeutic potential for the treatment of colic and/or diarrhea.
Care for Patients with Type II Diabetes in Primary Care
Authors: Herrera Sávia Denise Silva Carlotto , Guedes Anna Carolina Lacerda , Oliveira Neilton Araujo de , Silva Marcos Gontijo da , Souza Júnior Júlio Cezar Castro de , Duarte Rayssa Cláudia Oliveira , Araújo Warly Neves , Alves Rafaela de Carvalho , Silveira Janne Marques da , Hernández Yuniel Martínez 
Published: March 2020

Objective: To evaluate the influence of Medical Residency Program Health in Family and Community (MRPHFC) on the quality of care and prevention of type II diabetes mellitus (DM II) provided by basic health units (BHU) in Gurupi-TO.
Methodology: Descriptive, cross-sectional and retrospective research carried out in 12 BHU in the urban area of Gurupi-TO, to compare the primary care provided in the BHU that have the medical residency program, with those who do not have the program, through of the QualiAB 2016 tool that evaluates the conduct of the servers, 107 medical health professionals, nurses, nursing technicians and community health agents were surveyed, 61 in BHU with MRPFCH and 46 without. The data were tested by the chi-square test to verify if there is a difference in the service considering p≤5% or 0.05.
Results: The BHU with MRPFCH performance presented more significant results in most of the items studied.
Conclusion: The presence of MRPFCH programs contributes significantly to quality improvement in preventive care that is extremely important in the prevention and management of chronic comorbidities in patients with DM II.
Self‐Crystallized Multifunctional 2D Perovskite for Efficient and Stable Perovskite Solar Cells
Authors: Kim Hobeom , Pei Mingyuan , Lee Yonghui , Sutanto Albertus A. , Paek Sanghyun , Queloz Valentin I. E. , Huckaba Aron J. , Cho Kyung Taek , Yun Hyung Joong , Yang Hoichang , Nazeeruddin Mohammad Khaja 
Published: March 2020

AbstractRecently, perovskite solar cells (PSC) with high power‐conversion efficiency (PCE) and long‐term stability have been achieved by employing 2D perovskite layers on 3D perovskite light absorbers. However, in‐depth studies on the material and the interface between the two perovskite layers are still required to understand the role of the 2D perovskite in PSCs. Self‐crystallization of 2D perovskite is successfully induced by deposition of benzyl ammonium iodide (BnAI) on top of a 3D perovskite light absorber. The self‐crystallized 2D perovskite can perform a multifunctional role in facilitating hole transfer, owing to its random crystalline orientation and passivating traps in the 3D perovskite. The use of the multifunctional 2D perovskite (M2P) leads to improvement in PCE and long‐term stability of PSCs both with and without organic hole transporting material (HTM), 2,2′,7,7′‐tetrakis‐(N,N‐di‐p‐methoxyphenyl‐amine)‐9,9′‐spirobifluorene (spiro‐OMeTAD) compared to the devices without the M2P.
A Surface‐Tailoring Method for Rapid Non‐Thermosensitive Cell‐Sheet Engineering via Functional Polymer Coatings
Authors: Baek Jieung , Cho Younghak , Park Hyun‐Ji , Choi Goro , Lee Jong Seung , Lee Minseok , Yu Seung Jung , Cho Seung‐Woo , Lee Eunjung , Im Sung Gap 
Published: March 2020

AbstractCell sheet engineering, a technique utilizing a monolayer cell sheet, has recently emerged as a promising technology for scaffold‐free tissue engineering. In contrast to conventional tissue‐engineering approaches, the cell sheet technology allows cell harvest as a continuous cell sheet with intact extracellular matrix proteins and cell–cell junction, which facilitates cell transplantation without any other artificial biomaterials. A facile, non‐thermoresponsive method is demonstrated for a rapid but highly reliable platform for cell‐sheet engineering. The developed method exploits the precise modulation of cell–substrate interactions by controlling the surface energy of the substrate via a series of functional polymer coatings to enable prompt cell sheet harvesting within 100 s. The engineered surface can trigger an intrinsic cellular response upon the depletion of divalent cations, leading to spontaneous cell sheet detachment under physiological conditions (pH 7.4 and 37 °C) in a non‐thermoresponsive manner. Additionally, the therapeutic potential of the cell sheet is successfully demonstrated by the transplantation of multilayered cell sheets into mouse models of diabetic wounds and ischemia. These findings highlight the ability of the developed surface for non‐thermoresponsive cell sheet engineering to serve as a robust platform for regenerative medicine and provide significant breakthroughs in cell sheet technology.
Fast Sodium Storage with Ultralong Cycle Life for Nitrogen Doped Hollow Carbon Nanofibers Anode at Elevated Temperature
Authors: Chen Zhuowen , Duan Huanhuan , Xu Zhiguang , Chen Caihong , Yan Yurong , Wu Songping 
Published: March 2020

AbstractSodium ion batteries have been suffering low reversible capacity, poor rate, and less cycling reliability upon sodiation/desodiation. To address those formidable issues, electrospinning combined with hard template route is adopted here to collect loofah‐like nitrogen‐doped hollow carbon nanofibers (NHCNFs) derived from sustainable and low‐cost resources, that is, renewable acrylic yarn. NHCNFs render a remarkable reversible capacity of 143 mAh g−1 for 5000 cycles at a current density of 10 A g−1 at ambient temperature. More importantly, NHCNFs possesses an impressive capability in tackling the elevated temperature environment, affording an admirable reversible capacity of 156 mAh g−1 at a high rate of 15 A g−1 even after 10 000 cycles under 50 °C. These superior performances could be attributed to the combination of the following factors: delicately designed microstructure with hollow bead‐like channels, pseudocapacitive behavior and accelerated kinetics. Such an excellent attribute enables loofah‐like NHCNFs to be a promising low‐cost and environment‐friendly anode for sodium ion rechargeable batteries.
Suzuki‐Miyaura Cross‐Coupling of Amides using Well‐Defined, Air‐Stable [(PR3)2Pd(II)X2] Precatalysts
Authors: Ma Siyue , Zhou Tongliang , Li Guangchen , Szostak Michal 
Published: March 2020

AbstractA versatile method for the Suzuki‐Miyaura cross‐coupling of amides using highly active, well‐defined, and air‐stable Pd−phosphine precatalysts is reported. Most notably, the method represents the first example of using practical and operationally‐simple Pd(II)−phosphine precatalysts in the emerging amide bond cross‐coupling manifold. The reactions are efficient at 0.10 mol% loading, furnishing biaryl ketones with high chemoselectivity for N−C(O) bond cleavage. This versatile method enables for the first time to achieve Pd−phosphine‐catalyzed cross‐coupling of amides at ppm loading. This C−N cross‐coupling can be used to efficiently furnish pharmaceutical intermediates by orthogonal Pd‐catalyzed cross‐couplings. We fully expect that operationally‐simple [(PR3)2Pd(II)X2] precatalysts as effective triggers for N−C(O) cross‐coupling will be of broad synthetic and catalytic interest.magnified image
Highly Effective Work Function Reduction of α‐Borophene via Caesium Decoration: A First‐Principles Investigation
Authors: Zheng Bing , Xie Ying , Deng Ying‐yi , Wang Zhao‐qi , Lou Yuan‐qing , Qian Yin‐yin , He Jing , Yu Hai‐tao 
Published: March 2020

AbstractBorophene‐based nanocomposite is envisioned as a highly promising electrode material for nanoscale electronic devices such as light‐emitting diodes, organic solar cells, and field emitters. Therefore, engineering the work function of borophene to an optimal value is crucial for maximizing both conversion efficiency and device performance. A first‐principles density functional theory is employed to investigate the effects of Cs decoration on the structure, electronic properties, and work function of α‐borophene. The results indicate that Cs decoration effectively reduces the work function of α‐borophene (4.16 eV) to 3.05–0.11 eV at varying Cs concentrations, superior to those obtained in previous studies for Li (or other metal atom) decoration. Notably, work functions of all (but one) optimized Cs‐decorated α‐borophene configurations are lower than those of the commonly used electrode materials, Mg and Ca. Additionally, this study comprehensively investigates factors contributing to the work function reduction of Cs‐decorated α‐borophene relative to α‐borophene. Further, the results indicate that Cs decoration is a simple and effective method for decreasing the work function. Therefore, Cs‐decorated α‐borophene nanomaterials can be potentially utilized as cathode materials in electronic devices due to their metallic character and extremely low work functions.
Transition‐Metal‐Free Oxidative Cross‐Coupling of Tetraarylborates to Biaryls Using Organic Oxidants
Authors: Gerleve Carolin , Studer Armido 
Published: March 2020

AbstractReadily prepared tetraarylborates undergo selective (cross)‐coupling through oxidation with Bobbitt's salt to give symmetric and unsymmetric biaryls. The organic oxoammonium salt can be used either as a stoichiometric oxidant or as a catalyst in combination with in situ generated NO2 and molecular oxygen as the terminal oxidant. For selected cases, oxidative coupling is also possible with NO2/O2 without any additional nitroxide‐based cocatalyst. Transition‐metal‐free catalytic oxidative ligand cross‐coupling of tetraarylborates is unprecedented and the introduced method provides access to various biaryl and heterobiaryl systems.
Tensile testing and fracture mechanism analysis of polyvinyl alcohol nanofibrous webs
Authors: Lou Lihua , Yu Weijie , Kendall Ronald J. , Smith Ernest , Ramkumar Seshadri S. 
Published: March 2020

AbstractA tensile properties testing study was conducted to understand the influence of thickness, cross‐head speed (speed of testing), gauge length (GL; specimen test length), and sample shape on important tensile properties of polyvinyl alcohol (PVA) nanofiber webs. The effects of each testing parameter on load at break, extension at break, Young's modulus, and tensile stress–strain curve of PVA nanofiber webs are analyzed. The Welch two samplet‐tests show the significant difference among tested data. Using interaction plots, two‐way analysis of variance, and margin mean plots, the interaction effects among testing parameters have been analyzed. Of all the factors, cross‐head speed, the interaction among GL, and sample thickness (GL: Thickness) and the interaction among GL, testing speed and sample thickness (GL: Speed: Thickness) have significant influence on the tensile properties of PVA nanofiber webs. Moreover, the hypothesized model of mechanism of tensile strain–stress curve of PVA nanofiber webs has been proposed. Based on the model, the tensile strain–stress curve can be split into three stages: linear elastic, partial break up, and complete breakage. This study will provide a better understanding of tensile testing parameters' effects and their interaction effects on the tensile properties of nanowebs.
Discrete‐time mean‐field stochastic linear‐quadratic optimal control problem with finite horizon
Authors: Song Teng , Liu Bin 
Published: March 2020

AbstractIn this paper we consider the discrete‐time mean‐field stochastic linear‐quadratic (MF‐LQ) optimal control problem with indefinite weighting matrices. First, we establish the maximum principle, and by the solvability of mean‐field forward‐backward stochastic difference equations derived from the maximum principle, we characterize the existence of the open‐loop optimal control for the MF‐LQ problem. Then, by virtue of introducing the linear matrix inequalities condition, we obtain the solvability of the generalized difference Riccati equations (GDREs). Moreover, we show that the indefinite MF‐LQ problem is well‐posed if and only if the GDREs are solvable. Finally, a numerical example is used to show the effectiveness of the obtained results.
Surface‐enhanced Raman spectroscopy for on‐site analysis: A review of recent developments
Authors: Sun Ji , Gong Lin , Wang Wenjun , Gong Zhengjun , Wang Dongmei , Fan Meikun 
Published: March 2020

AbstractOn‐site identification and quantification of chemicals is critical for promoting food safety, human health, homeland security risk assessment, and disease diagnosis. Surface‐enhanced Raman spectroscopy (SERS) has been widely considered as a promising method for on‐site analysis due to the advantages of nondestructive, abundant molecular information, and outstanding sensitivity. However, SERS for on‐site application has been restricted not only by the cost, performance, and portability of portable Raman instruments, but also by the sampling ability and signal enhancing performance of the SERS substrates. In recent years, the performance of SERS for on‐site analysis has been improved through portable Raman instruments, SERS substrates, and other combined technologies. In this review, popular commercial portable Raman spectrometers and the related technologies for on‐site analysis are compared. In addition, different types of SERS substrates for on‐site application are summarized. SERS combined with other technologies, such as electrochemical and microfluidics are also presented. The future perspective of SERS for on‐site analysis is also discussed.
‘Turn‐on’ fluorescence sensing of hydrogen peroxide in marine food samples using a carbon dots–MnO2 probe
Authors: Ning Keke , Xiang Guoqiang , Wang Cuicui , Huang Feihong , Liu Jinzhi , Zhang Lanlan , Yan Minmin , Hu Bingqian , Lei Wen 
Published: March 2020

AbstractA ‘turn‐on’ fluorescence method for detection of hydrogen peroxide (H2O2) in marine food samples is presented in this article. Using this method, a carbon dots (CDs)–MnO2 probe was formed in which fluorescence intensity (FI) of CDs was quenched through fluorescence resonance energy transfer by addition of MnO2 nanosheets. When H2O2 was added into the CDs–MnO2 solution, the MnO2 nanosheets formed Mn2+ ions due to a redox reaction between H2O2 and MnO2 nanosheets, and CD FI was recovered. Under optimized conditions, the detection limit for H2O2 was 0.87 μM, and analytical linear range was 4–100 μM. Furthermore, this developed fluorescence sensing system was successfully used with satisfactory results to determine trace H2O2 content in marine food samples.
Differences in physician opinions about controversial issues surrounding contralateral prophylactic mastectomy (CPM): A survey of physicians from accredited breast centers in the United States
Authors: Yao Katharine , Bleicher Richard , Moran Meena , Chang Cecilia , Dietz Jill , Stearns Vered , Connolly James , Sarantou Terry , Kurtzman Scott ,   National Accreditation Program for Breast Centers Data Working Group
Published: March 2020

AbstractBackgroundIndications and insurance coverage for contralateral prophylactic mastectomy (CPM) and CPM as a quality measure are controversial. Few studies have examined physician opinions on these issues.MethodsA cross‐sectional survey of multi‐specialty physicians at the National Accreditation Program for Breast Centers from 2017‐2018 examined opinions on insurance coverage for CPM, CPM as a quality measure, and indications for CPM. A multivariate logistic regression was used to assess physician and facility factors associated with likelihood to recommend CPM.ResultsOf 2412 physicians, 1226 responded from 382 facilities for a physician response rate of 50.8%. There were 300 (24.5%) medical oncologists, 316 (25.8%) radiation oncologists, 248 (20.2%) plastic surgeons, and 322 (26.3%) oncologic or general surgeons. Three hundred and ninety‐eight (37%) physicians favor insurance coverage for all patients and 520 (46.6%) for patients at average CBC risk. Four hundred and fifty (40%) of all physicians felt physician specific rates of CPM should be a hospital quality measure. BRCA deleterious mutation carrier status was the most common indication to recommend CPM (n = 1043; 92%) and 684 (60.2%) physicians discourage CPM for average contralateral risk (CBC) patients. After adjusting for physician and facility factors, the only significant predictor of higher likelihood to recommend CPM for average CBC risk patients were plastics surgeons (OR = 8.3 (95%CI 2.4‐29.1)) P = .0009).ConclusionThere is consensus among physicians on the most appropriate indication for CPM but opinions vary on CPM as a quality measure and insurance coverage for CPM. These findings can help guide discussions on CPM among a multidisciplinary team of physicians.
Time to diagnostic resolution after an uncertain screening mammogram in an underserved population
Authors: Kumar Anita J. , Banco Darcy , Steinberger Elise E. , Chen Joanna , Weidner RuthAnn , Makim Shital , Parsons Susan K. 
Published: March 2020

AbstractBackgroundScreening mammography has reduced breast cancer–associated mortality worldwide. Approximately 10% of patients require further diagnostic testing after an uncertain screening mammogram (Breast imaging reporting and data system [BI‐RADS] = 0), and time to diagnostic resolution varies after BI‐RADS = 0 screening mammogram. There is little data about factors associated with diagnostic resolution in patients of Chinese origin (“Chinese”) receiving care in the US.MethodsWe performed a retrospective analysis to identify patterns of diagnostic resolution in an urban US hospital with a large population of Chinese patients. We evaluated whether location of primary care provider (PCP) impacted time to resolution among Chinese patients, hypothesizing that patients with a PCP outside of the hospital would have longer time to diagnostic resolution than those patients with a PCP within the institution.ResultsBetween 2015 and 2016, 368 patients at Tufts Medical Center (Tufts MC) had resulting BI‐RADS = 0 after screening mammogram. The majority of patients (341/368, 93%) achieved diagnostic resolution with median time to resolution 27 days (Q1: 14, Q3: 40). Seven percent (27/368) never achieved resolution. Among those with diagnostic resolution, 10% of patients required >60 days to achieve resolution. Chinese origin, no previous breast cancer, subsidized insurance, and outside referring physician were associated with longer time to resolution in univariable analysis. In multivariable regression, after adjusting for age, insurance, marital status, and prior breast cancer, Chinese patients with Tufts MC PCP experienced timelier diagnostic resolution vs Chinese patients without a Tufts MC PCP (hazard ratio [HR] = 1.85, P = .02). Location of PCP did not impact time to resolution among non‐Chinese patients.ConclusionWe identified patterns of diagnostic resolution in an urban hospital with a large historically underserved population. We found that Chinese patients without integrated primary care within the institution are at risk for delayed diagnostic resolution. Future interventions need to target at‐risk patients to prevent loss of follow‐up after uncertain screening mammogram.
LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling
Authors: Dong XueMei , Xu Xin , Guan YanPing 
Published: March 2020

Long non‐coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo. Besides, LINC00899 acted as a molecular sponge of miR‐744‐3p. Furthermore, we characterized YY1 as the direct target of miR‐744‐3p, and LINC00899/miR‐744‐3p interaction modulated YY1 expression in AML cells. Finally, we verified LINC00899 modulated AML cell proliferation and apoptosis via regulating YY1. Our study revealed novel mechanism about how did lncRNA LINC00899 execute function in AML and thus provided potential therapeutic interventions for AML.Significance of the study
LncRNA LINC00899 is upregulated in AML cells and is correlated with poor prognosis of AML patients.
LncRNA LINC00899 mediates cell proliferation and apoptosis of acute myeloid leukaemia cells.
Knockdown of LINC00899 inhibited the growth of xenograft glioma tumour in vivo.
LINC00899 acts as a molecular sponge of miR‐744‐3p.
YY1 is the downstream target of LINC00899/miR‐744‐3p signalling.
YY1‐induced upregulation of FOXP4‐AS1 and FOXP4 promote the proliferation of esophageal squamous cell carcinoma cells
Authors: Li Yonghui , Li Tingting , Yang Yongbin , Kang Wenli , Dong Shaoyong , Cheng Shujie 
Published: March 2020

AbstractEsophageal squamous cell carcinoma (ESCC) belongs to one of the most common malignant tumors worldwide and possesses high mortality. Long non‐coding RNAs (lncRNAs) have been demonstrated to be essential biological participants in the progression of ESCC. On the basis of bio‐informatics prediction, forkhead box P4 antisense RNA 1 (FOXP4‐AS1) and forkhead box P4 (FOXP4) were upregulated in esophageal carcinoma samples and were positively correlated with each other. The present study aimed to explore the function of FOXP4‐AS1 and FOXP4 in ESCC cells. Function assays disclosed that knockdown of FOXP4‐AS1 or FOXP4 efficiently suppressed cell proliferation and induced cell apoptosis. Moreover, FOXP4‐AS1 positively regulated FOXP4 by interacting with insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) to stabilize FOXP4 messenger RNA. In addition, FOXP4‐AS1 could upregulate the expression of FOXP4 by sponging miR‐3184‐5p. Finally, we found that Yin Yang 1 (YY1) is a transcription factor that can transcriptionally activate both FOXP4‐AS1 and FOXP4 in ESCC cells. In a word, YY1‐induced upregulation of FOXP4‐AS1 and FOXP4 promote the proliferation of ESCC cells