bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic and clinicopathological significance of YAP in Colorectal carcinoma: A systematic review and meta-analysis
Authors: Dai Lu , Jin Xiao , Wang Jiayan , Ma Yilan , Yan Haihao , Jin Ye , Zhu Xiaojuan , Liu Zheng 
Published: June 2020

Abstract
Background: YAP is a protein encoded by the YAP gene in humans. Numerous studied showed that YAP expressed in colorecal carcinoma (CRC) and has a association with poor clinical outcomes. However, the association between YAP expression level with prognostic and clinicopathological features in CRC patients remains unclear. Therefore, we performed a meta-analysis to investigate the prognostics effect of YAP expression on CRC patients.Methods: A systematic search of the PubMed, Web of Science, Cochrane Library and Embase databases was conducted based on predefined selection criteria in April 26, 2020. The correlation between YAP expression level and survival outcomes or clinicopathological characteristic was analyzed by hazard ratios (HR) or odds ratios (OR) at 95% confdence intervals (CI).Results: 12 studies were included, with a total of 2286 CRC patients,in our meta-analysis.the results show the relationship between YAP expression level with overall survival (OS) in CRC patients HR (2.02, 95%CI 1.67-2.44 I2 =19.7% P= 0.25) . In addition to clinicpathological features, CRC patients with overexpression of YAP were tend to advanced TNM stage(OR:2.99, 95%CI 2.11-4.25, I2=0.0%, P=0.699), lymph node metastasis(OR:3.73, 95% CI 2.63-5.30, I2=4.8%, P=0.386), distant metastasis(OR:3.03, 95% CI 1.21-7.56, I2=65.3%, P=0.021), tumor invasion depth HR (2.82 95%CI 1.65-4.83 I2=0.0%, p=0.413), but have no associated with sex, tumor size, tumor location and tumor differentiation.Conclusion: The results of this meta-analysis show that high expression of YAP tended to have a worse progosis and have great influence on clinicpathological features. which means YAP may serve as a promising indicator in the prediction of prognosis and clinicopathological features in CRC patients.
Designing a nursing care plan based on Johnson's behavioral model in patients with wrist joint hematoma: A case study
Authors: Karkhah Samad , Ghazanfari Mohammad Javad , Norouzi Masoumeh , Khaleghdoust Tahereh , Dahka Samane Mirzaie , Taheri Zahra , ghanbari atefeh 
Published: June 2020

Abstract
BACKGROUND

Nurses can diagnose patients' problems using Johnson's pattern of behavior. This model is applicable and nurses can design and implement patient-based care in a clinical setting based on this model. This study was designed to use Johnson's behavioral model in the care of a middle-aged woman suffering from pain, edema and severe left wrist hematoma.
Methods

This study was conducted with the aim of determine the nursing care plan based on Johnson's behavioral model in patient with wrist joint hematoma in Iran since December 27, 2019 to January 4, 2020, on a case referred to Poursina Hospital in Rasht, Guilan Province, Iran. After assessing the patient, we propound seven main nursing diagnoses and planned them in 9 days according to the model.
Results

After evaluating the patient, the care program was implemented based on Johnson's behavioral model. We achieved caring goals after the intervention. Her appetite and sleep were better, and she became aware of the side effects of her lack of diet and care. She made more efforts to self-care. By using Johnson's care system after 9 days of inpatient care, she has improved her sense of independence, range of motion, self-esteem, sleep quality, increased desire for food, improved excretion and constipation, and we adjusted to reduce libido and use complementary therapies to improve it.
Conclusion

This model can be used as a general framework in the hospital to diagnose problems, evaluate and design a care program.
Follow Up The Children With Ocular Lesion Induced by Two Common Intrauterine Infections(Cytomegalovirus,Toxoplasmosis): A Cohort Study in Tehran,Iran
Authors: Vafaee-Shahi mohammad , noorbakhsh samileh , Tahernia leila , ashouri sarvenaz 
Published: June 2020

Abstract
Background: Intrauterine infections lead to involvement of various organs in fetus, including the eye. The aim of this study was to determine the frequency and clinical response of ocular lesions to specific drugs in infants with congenital Toxoplasma and cytomegalovirus infections.Methods: This historical cohort study was performed in the pediatric and ophthalmology department of Hazrat Rasool Akram Hospital in Tehran from October 2011 to November 2017. Patients included 78 infants with intrauterine infection (proven) and ocular involvement (cataracts, glaucoma, and retinitis). Infants who did not undergo additional and diagnostic tests, eye examinations, follow-up and did not receive effective treatment were excluded from the study. Three patients expired during the study. Finally, 37 patients (including 25 patients with cytomegalovirus and 12 patients with toxoplasma) were included to assess and the clinical response to ocular lesions was evaluated for one year.Results: Of 12 cases with toxoplasmosis, 5 patients received complete treatment and 4 patients had appropriate clinical responses. Of 25 patients with CMV, 18 patients received complete treatment and 9 patients had appropriate clinical responses.Conclusion: Successful treatment will be obtained in near 80% of ocular toxoplasmosis,so anti toxoplasma treatment is recommended in all confirmed cases .About 50% of CMV infected cases (with hearing loss, ocular involvement ) might respond well to antiviral therapy, We recommend anti CMV treatment in any age ( <2 years old) but it is not indicated in CMV infected cases with severe brain involvement.
Femtosecond Laser-Assisted Cataract Surgery in Glaucoma Patients, Case Series.
Authors: Alvarez-Ascencio Daniela , Prado-Larrea Carolina Fernanda , Jimenez-Roman Jesus , Castañeda-Diez Rafael 
Published: June 2020

Abstract
BackgroundWe aim to describe the short-term effect of femtosecond laser-assisted cataract surgery (FLACS) in intraocular pressure (IOP), visual acuity (VA), number of hypotensive medications, and visual fields (VF) in glaucomatous eyes.MethodsSingle-center consecutive case series study included patients with a previous glaucoma diagnosis that needed cataract surgery alone or combined with incisional glaucoma procedure. IOP was measured during surgery immediately before and after pretreatment docking with an indentation tonometer. Changes in visual acuity (VA), IOP, number of medications, and VF were evaluated with a 90 day follow up.ResultsTwenty-seven eyes of 27 patients were included. Mean patient age was 70 years, 70% (n = 19) were female. Glaucoma diagnoses were: twelve patients with primary open-angle glaucoma, 13 with angle-closure glaucoma, and 2 with pseudoexfoliation glaucoma. Twenty-one patients underwent cataract surgery alone and 6 combined with an incisional glaucoma procedure (trabeculectomy or glaucoma drainage device implantation). We found no significant differences between pre-docking IOP (17.59 mmHg ± 6.25 SD) and post-docking IOP (17.23 mmHg ± 7.74 SD) p = 0.7. No surgical complications were recorded. The 90-day postoperative follow up revealed no changes from baseline regarding VF mean deviation, mean IOP, and the number of glaucoma medications decreased in both groups.ConclusionFLACS appears to perform well in the short-term in eyes with glaucoma undergoing cataract surgery alone or with an incisional glaucoma procedure. Comparable outcomes to manual phacoemulsification were obtained regarding IOP, VA, and postoperative period evolution.Clinical SignificanceSafety and efficacy of FLACS have not been properly studied in the glaucoma population, we present a case series with different glaucoma diagnoses who underwent FLACS alone or with an incisional glaucoma procedure.
Hot spot identification by means of classification methods employing wavelet transform-based features
Authors: Tamulewicz Anna , Tkacz Ewaryst , Provazník Ivo 
Published: June 2020

Abstract
Background: Proteins can interact with one another by an interface composed of two proteins. Some of the interface residues - called hot spots - have the greatest impact on binding energy in a protein complex. This paper introduces the application of continuous wavelet transform based on the fast Fourier transform (CWTFT) to the analysis of hot spots in proteins.Results: The algorithm was evaluated by using data sets containing 30 proteins. From the number of tested classifiers the best 10 models were preferred. The classifiers achieved sensitivity of 52% - 71%, specificity of 70% - 83% and accuracy of 70% - 74%.Conclusion: The analyses show that the method combining CWTFT and classification algorithms is able to identify hot spot residues with valuable results.Methods: The basis of the algorithm is extraction of features from spectra obtained by using CWTFT with different wavelet functions including Morlet, m^th order derivative of Gaussian, Paul and Bump wavelets. Then, the classifiers that are able to separate hot spot from non-hot spot residues according to these features are applied.
High intensity versus low intensity family-based childhood obesity treatment programs: Effectiveness, engagement and implementation outcomes from a randomized controlled trial in medically underserved region
Authors: Zoellner Jamie , You Wen , Hill Jennie , Brock Donna-Jean , Yuhas Maryam , Price Bryan , Wilson Jonathon , Montague Danielle Renee , Estabrooks Paul 
Published: June 2020

Abstract
Background

Access to evidence- and family-based childhood obesity (FBCO) treatment interventions in the US is a challenge, especially in medically underserved regions where disparities in childhood obesity persist.
Methods

A comparative effectiveness RCT of two 6-month FBCO treatment interventions varied in structure and contact hours—iChoose (high intensity) and Family Connections (low intensity)—in a medically underserved region. Guided by a systems-based and community-based participatory research approach and the RE-AIM planning and evaluation framework, this paper reports on effectiveness (BMI z-scores) and implementation outcomes. Changes in parent outcomes, secondary outcomes (e.g. QOL, nutrition, physical activity), engagement, and implementation costs are also reported. Analyses included descriptive statistics and intention-to-treat Heckman treatment effect models with cluster robust inference adjustment.
Results
Enrolled children (n = 139, mean age 10.1 ± 1.7 years, 30% overweight, 70% obese, 45% black, 63% on Medicaid) were randomly assigned to iChoose (n = 70) or Family Connections (n = 69). Retention rates were 63% for iChoose and 84% for Family Connection. Among children, 6-month BMI z-score changes were not statistically significant within iChoose [BMI z-score 0.03 (95% CI = -0.13, 0.19)] or Family Connections [BMI z-score 0.00 (95% CI = -0.16, 0.16)]. Likewise, relative between condition effects were not statistically significant and similar null effects were found in parents’ BMI changes. Yet relative to iChoose, Family Connections parents had significant improvement in quality of life (p = 0.03). Both programs were delivered with high fidelity (77–100%). iChoose engagement was 30% family classes, 36% IVR calls, and 25% physical activity classes; Family Connections engagement was 52% parent classes and 61% IVR calls. Implementations costs per children with improved BMI z-score was $2,841 for iChoose and $955 for Family Connections.
Conclusions

Both FBCO treatment interventions were delivered with high fidelity; yet neither yielded significant improvements in child or parent BMI. Relative to iChoose, descriptive data indicated higher retention, better engagement, and lower costs for Family Connections—suggesting that a lower intensity program may better fit the intended audience’s context. Future research efforts need to address lack of program effects and further explore strategies to leverage higher engagement in lower intensity programs for populations in medically underserved areas.
Trial registration:

Clincialtrials.gov: NCT03245775. Registered 10 August 2017. https://clinicaltrials.gov/ct2/show/NCT03245775?term=NCT03245775&draw=2&rank=1
Alarming Symptoms Leading To Severe COVID-19 Pneumonia: A Meta-Analysis
Authors: Ji Weiping , Zhang Jing , Bishnu Gautam , Du Xudong , Chen Xinxin , Xu Hui , Guo Xiaoling , Cai Zhenzhai , Zhang Jun , Shen Xian 
Published: June 2020

Abstract
Background: To identify alarming symptoms that could potentially lead to severe form of COVID-19 pneumonia (i.e. novel coronavirus pneumonia: NCP), a disease that is now having pandemic spread.Methods: Articles from PubMed, Embase, Cochrane database and Google up to 24 February 2020 were systematically reviewed. 18 publications that had documented cases of COVID-19 pneumonia were identified. The relevant data were extracted, systematically reviewed and further evaluated using meta-analysis. We define severe COVID-19 pneumonia as the disease status that requires admission to the intensive care unit (ICU) and respiratory/circulatory support, which is in align with the guideline from the World Health Organization (WHO).Results: 14 studies including 1,424 patients were considered eligible and analyzed. Symptoms such as fever (89.2%), cough (67.2%), fatigue (43.6%) were quite common; but dizziness, hemoptysis, abdominal pain and conjunctival congestion/conjunctivitis were relatively rare. The incidence of dyspnea was significantly higher in patients with severe than non-severe COVID-19 pneumonia (42.7% vs.16.3%, p<0.0001). Similarly, fever and diarrhea were also drastically more common in patients with severe form (p=0.0374 and 0.0267). Further meta-analysis using three high-quality China-based studies confirmed such findings and showed that dyspnea, fever and diarrhea were 3.53 (OR: 3.53, 95%CI: 1.95-6.38), 1.70 (OR: 1.70, 95%CI: 1.01-2.87), and 1.80 (OR: 1.80, 95%CI: 1.06-3.03) folds higher respectively in patients with severe COVID-19 pneumonia.Conclusion: Dyspnea, fever and diarrhea are significantly more prevalent in patients with severe COVID-19 pneumonia, suggesting they are alarming symptoms that warrant close attention and timely management.
Variation in Seedling Germinationand Growth in Five Populations Ofvitellariaparadoxa C.F. Gaertn.subsp. Nilotica: A Threatenedusefulfruit Tree Species in Uganda
Authors: Odoi Juventine Boaz , Odong Thomas L. , Okia Clement Akias , Okullo JohnBosco Lomoris , Okao Moses , Kabasindi Harriet , Muchugi Alice , Gwali Samson 
Published: June 2020

Abstract
Background: We studied seedlings germination and growth performance in an economically and socially important fruit tree species of Vitellaria paradoxaC.F. Gaertn.subsp. nilotica (Kotschy) in Uganda. The study aimed at determining variability in germination of the five shea tree seed lots and seedlings growth performance based on their growth traits. Five populations were considered from four agroecological zones of Uganda and 180 candidates plus trees (16 ethnovarieties) selected as seed trees based on their traits for faster growth and high oil yield. A total of 1204 biological seeds were collected and sown in a general tree nursery at Ngetta Zonal Agricultural Research and Development Institute (NgeZARDI)during the month of June 2018 in a randomized incomplete block design with three replications. Results: Significant variation (χ = 526; p < 0.01) was observed in seedling phenotypic traits within and between populations. Regression equation for height growth and leaf size index were given asy = 0.3787 + 12.671x and y = 0.6483 + 15.413x respectively. Root collar diameter was more correlated to leaf size index (0.425) than to height growth (0.30). Clustering of shea tree seedlings based on phenotypic growth traits revealed one aggregated cluster indicating that most of the seedlings from the five populations were similar (Jaccard index 0.92, p < 0.01). However, clustering based on SNP markers revealed three different populations. We recorded higher growth (χ = 708; p< 0.001) in Arua shea population (19.69 cm)compared to the population average (19.04 cm). Red seeded; thin pulped and hairy fruited shea tree ethnovarieties assumed faster growth than the rest. Conclusions: The phenotypic analysis of shea tree seedlings revealed some fast-growing genotypes from the five studied populations. Thesegenotypes can be selected for faster growth for shea tree breeding in Uganda.
Identify Key Active Ingredients and Molecular Mechanisms of Jiangzhi Decoction on Non-alcoholic Fatty Liver Disease by Network Pharmacology Analysis
Authors: Wang Lei , Zhi Yin , Ye Ying , Zhang Miao , Ma Xing , Tie Hongyun , Xia Wei , Song Yanan 
Published: June 2020

Abstract
Background: Jiangzhi Decoction (JZD), a traditional herb mixture, has shown significant clinical efficacy against non-alcoholic fatty liver disease (NAFLD). However, its multicomponent and multitarget characteristics bring difficulty in deciphering its pharmacological mechanisms. Our study aimed to identify the key active ingredients and core molecular mechanisms of JZD against NAFLD. Methods: The active ingredients were searched from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and Traditional Chinese Medicine Integrated Database (TCMID). The targets of those ingredients were identified using ChemMapper database based on 3D-structure similarity. NAFLD-related genes were searched from DisGeNET database and Gene Expression Omnibus (GEO) database. Then we obtained candidate targets of JZD against NAFLD by overlapping the active ingredient targets and NAFLD-related genes. We performed protein-protein interaction (PPI) analysis, functional enrichment analysis and constructed pathway networks of “herbs-active ingredients-candidate targets”, and identified the key active ingredients and core molecular mechanisms in the network. Results: We found 147 active ingredients in JZD, 1285 targets of active ingredients, 401 NAFLD-related genes, and 59 overlapped candidate targets of JZD against NAFLD. 22 core targets were obtained by PPI analysis. Finally, nuclear receptor transcription and lipid metabolism regulation were found as the core molecular mechanisms of JZD against NAFLD by functional enrichment analysis, and emodin, emodin anthrone, hyperin, questin, rhein, etc. were speculated as the key active ingredients of JZD. Conclusion: Our study will provide the scientific evidences of the clinical efficacy of JZD against NAFLD.
Association of coffee and caffeine intake with irritable bowel syndrome in adults
Authors: Koochakpoor Glareh , Salari-Moghaddam Asma , Keshteli Ammar Hassanzadeh , Esmaillzadeh Ahmad , Adibi Peyman 
Published: June 2020

Abstract
Background: The aim of this study was to investigate the association between coffee and caffeine intake and odds of IBS and its severity in adult population. Methods: In this cross-sectional study, dietary intakes of 3363 Iranian adults were examined using a validated dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). Coffee and caffeine intake was assessed using the DS-FFQ. IBS was assessed using a modified Persian version of Rome III questionnaire. Binary logistic regression, in which the effect of several potential confounders were controlled for, was used to examine the association between coffee and caffeine intake and prevalence of IBS and its subtypes. To identify the association with severity of IBS symptoms, we applied ordinal logistic regression. Results: After adjustment for potential confounders, we found that individuals who were taking coffee weekly or more had greater odds of IBS (OR:1.50; 95% CI: 1.07-2.11) than those who never drinking coffee. In addition, participants in the top tertile of caffeine intake had 49% greater odds of IBS compared to those in the bottom tertile (OR: 1.49; 95% CI: 1.16-1.90). By gender, this association was observed among women, but not in men (for coffee: OR: 1.50; 95% CI: 1.00-2.57 and for caffeine: OR: 1.50; 95% CI: 1.12-2.02). In addition, a significant positive association was seen between caffeine intake and odds of IBS among subjects with BMI≥25 kg/m2 (OR: 1.76; 95% CI: 1.22-2.53). There was no significant association between coffee and caffeine intake and IBS severity.Conclusion: Coffee and caffeine consumption was associated with increased odds of IBS, in particular among women and those with BMI ≥ 25 kg/m2.
MAG-DHA Induces Apoptosis and Autophagy in Breast Cancer Cells via Lipid Peroxidation-Mediated Endoplasmic Reticulum Stress
Authors: Zhang Jin-jie , Yang Yong , Wang Feng , Yang Wen-ge , zou Zuquan 
Published: June 2020

Abstract
Background: Epidemiologic and pre-clinical studies have shown that marine n-3 polyunsaturated fatty acids (n-3 PUFAs) elicit promising chemoprevention against breast cancer. Previous studies found that docosahexaenoic acid monoglyceride (MAG-DHA) does not required pancreatic lipase to be absorbed, unlike DHA-triglyceride which needs to be hydrolyzed by sn-1,3’ specific gastric and (colipase-dependent) pancreatic lipases as free fatty acids and monoglycerol prior to intestinal absorption. Therefore, this property confers increased absorption, and thus a better bioavailability when compared with other formulations such as DHA-free fatty acid, DHA-triglycerol (TAG-DHA), or DHA-ethyl ester (EE-DHA). However, the anti-cancer actions of n-3 PUFA monoglyceride on breast cancer remain to be assessed.Methods: SKBR3 and E0771 cells were exposed in vitro to MAG-DHA. Cell viability (by MTT), malondialdehyde (MDA) levels, cell apoptosis and autophagy (by western blot), Beclin1 knockout (by siRNA) was examined. Transmission electron microscopy (TEM) was used for analyzing cell apoptosis and autophagy in vivo breast cancer exnografts. Results: In this study, we showed that docosahexaenoic acid monoglyceride (MAG-DHA) caused oxidative stress as evidenced by MDA accumulation, which triggered endoplasmic reticulum (ER) stress and subsequently induced apoptosis in E0771 and SKBR3 breast cancer cells. In particular, MAG-DHA-induced apoptosis is associated with the activation of the PERK-eIF2α pathway and caspase-12. MAG-DHA treatment also strongly suppressed the growth of E0771 murine breast cancer xenografts, by ER-stress-induced cell apoptosis. In addition, we found that MAG-DHA-induced ER stress concomitantly triggered autophagy in these cancer cells, and the induction of autophagy suppressed its ability to induce apoptotic cell death. Conclusions: Together, our data suggested that MAG-DHA combined with autophagy inhibitors may be a useful therapeutic strategy in treating breast cancer.