bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregivers’ perceptions towards oral healthcare services for elders living in Malaysian nursing homes—A qualitative study
Authors: Letchumanan Devanthiran , Mohamad Norpi Nuratiqah , Yusof Zamros Yuzadi Mohd , Razak Ishak Abdul , Abu Kasim Noor Hayaty , Abdullah Nurrul Ashikin , Ramalingam Sheila Rani , Yacob Habibah , Abduludin Datu Mohd Amyril , Azmi Lily Laura , Abas Nurul Asniza , Lian Yaw Siew , Shamdol Zainab , Ishak Fatimah Arusah , Ismail Noor Aliyah , Abd Muttalib Khairiyah 
Published: March 2020

AbstractObjectiveTo assess the perceptions of caregivers towards oral healthcare services received by elders in Malaysian nursing homes and to identify challenges and suggestions for improvement.BackgroundCaregivers play an important role in the oral health care of elders in nursing homes.MethodsThis study employed a qualitative approach using the nominal group technique (NGT) to obtain caregivers’ feedback in nursing homes in Malaysia. Data were manually transcribed, summarised into keywords/key phrases, and ranked using weighted scores.ResultsIn total, 36 caregivers (21 from government and 15 from private nursing homes) participated in the NGT sessions. Overall, caregivers were satisfied with the low treatment cost, the quality of treatment, and the availability of dental visits to nursing homes. Caregivers were dissatisfied with the frequency of dental visits, long waiting times at government dental clinics, and inadequate denture hygiene education for elders in nursing homes. The challenges faced by caregivers were elders’ poor oral health knowledge and attitude and lack of elders’ trust of caregivers to look after their oral health. Suggestions for improvement were to increase the frequency of dental visits to nursing homes, provide oral health education to elders and caregivers, and give treatment priority to elders at dental clinics.ConclusionDespite being satisfied with the basic oral healthcare services received by elders in Malaysian nursing homes, caregivers raised some issues that required further attention. Suggestions for improvement include policy changes in nursing home dental visits and treatment priority for elders at government dental clinics.
Effects of feeding level of alfalfa hay on nitrogen utilization for 1‐kg daily gain of crossbred Simmental male calves
Authors: Kobayashi Nobuyuki , Hou Fujiang , Tsunekawa Atsushi , Chen Xianjiang , Yan Tianhai , Ichinohe Toshiyoshi 
Published: March 2020

AbstractIn Gansu Province, a key beef cattle production area in China, feeding systems are changing from grazing to stall‐feeding. To reduce production costs, alternative feeding regimens with domestic forages, such as alfalfa hay (AH), are needed. We evaluated the effects of the AH feeding level on nitrogen balance and daily gain (DG) of Simmental calves by two feeding trials. In trial 1, when AH was consumed at 0%–19% of total dry matter intake, no clear effect of AH intake on metabolizable‐protein supply and DG was observed. In trial 2, when more concentrate feed was fed than in trial 1, metabolizable‐protein supply and nitrogen retention increased as the AH consumption rate increased (0%–38% of total intake); these effects appeared to be related to the DG increase. Our results suggest that AH inclusion in concentrate‐based diets increases the metabolizable‐protein supply for the optimal DG of growing beef calves.
Evaluation of agronomic performance and exploratory genome‐wide association study of a diverse oat panel for forage use in Taiwan
Authors: Huang Chung‐Wen , Liang Wei‐Hong , Esvelt Klos Kathy , Chen Chia‐Sheng , Huang Yung‐Fen 
Published: March 2020

AbstractOats (Avena sativa L.) produce not only the well‐known highly nutritious grain, but valuable forage. In Taiwan, imported oat hay is a popular forage with the dairy cattle industry. However, local forage oat breeding and production have been virtually absent. Therefore, this study aimed to evaluate the forage performance of oats in Taiwan in order to assess their potential for local oat production. We have introduced 178 oat accessions from 18 breeding programs across North and South America. These breeding lines were evaluated in Northern Taiwan (Taipei) and Southern Taiwan (Hengchun) between autumn 2016 and spring 2017. Early maturing lines reached the flowering stage after ca. 70 or ca. 90 days after sowing in Hengchun and Taipei, respectively, while 49 and 159 lines remained vegetative throughout the growing season in Hengchun and Taipei, respectively. On average, plant height was taller in Taipei than in Hengchun (99.8 vs. 53.2 cm), while dry matter yield per plot was higher in Hengchun than in Taipei (596 vs. 388.4 g/Plot). Maturity and dry matter differences may be related to the differences in daily effective sunlight between locations. Using 1,164 genome‐wide single nucleotide polymorphisms (SNPs), we explored the population structure and the genetic architecture of traits of interest within a subset of 73 oat lines. No obvious sub‐populations were observed, which reflected the frequent material exchanges among oat breeders. Fifty‐three loci were associated with days to flowering, plant height and dry matter yield; and 12 of them overlapped with loci identified in previous work. The data and results of this study lay the foundations and provide guidelines for further forage oat breeding work in Taiwan.
Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid‐enriched fraction (MSEF) from buttermilk powder
Authors: Lee K. , Kim S. , Kim A. , Suh H.J. , Hong K.‐B. 
Published: March 2020

AbstractObjectiveIn this study, we isolated the milk sphingolipid‐enriched fraction (MSEF) of sweet buttermilk powder and conducted a clinical trial for evaluating its efficacy in skin barrier recovery.MethodsMilk sphingolipid‐enriched fraction was isolated via solvent extraction of buttermilk powder, and further concentrated by removing the phospholipids and neutral lipids. A cream containing 1% MSEF was used during clinical trials to assess for water holding and skin barrier recovery capacities.ResultsThe main components of the MSEF were sphingomyelin, glucosylceramide and lactosylceramide, confirmed by TLC, HPLC, MS and NMR. The MSEF cream‐treated group had a significantly higher (P < 0.05) water holding capacity, compared with the base cream (vehicle) group. Compared with that in the base cream group, transepidermal water loss (TEWL) recovery increased in the presence of the sphingolipid‐containing MSEF cream (MSEF group), with a significant difference (P < 0.05) recorded on day 14.ConclusionThe MSEF cream contributed to improving the water holding capacity and skin barrier recovery of damaged skin. Therefore, sphingolipid‐containing MSEF can be useful for strengthening or repairing skin barrier function.
Prevalence and characteristics of post‐colonoscopy colorectal cancers in a New Zealand regional centre: a 10‐year analysis
Authors: Willington Adam J. , Cosgrove Samuel , Davison Polly , Cunliffe Robert N. 
Published: March 2020

AbstractBackgroundPost‐colonoscopy colorectal cancers (PCCRC) are cancers that appear following a colonoscopy in which no cancer is diagnosed. The occurrence of PCCRC is thought to be multifactorial, reflecting both endoscopy quality and potential differences in tumour biology between detected colorectal cancers and PCCRC.AimTo identify the prevalence and characteristics of PCCRC in a New Zealand regional centre over a 10‐year period.MethodAll cases of colorectal cancer (n = 1055) in the Bay of Plenty region between 1 February 2009 and 1 February 2019 were cross‐referenced with endoscopy coding records to identify patients who had undergone colonoscopy within the preceding 6–60 months in which cancer was not identified.ResultsA total of 46 patients were identified to have PCCRC, giving a prevalence of 4.4%. The majority of these patients were older (80% aged 65 years or over) and female (67%). The mean interval between index colonoscopy and diagnosis of PCCRC was 3.03 years. Most (80%) patients had existent pathology (diverticular disease or colonic polyps) at index colonoscopy, and a significant proportion (43%) developed cancer in the same colonic segment. PCCRC were evenly distributed between the left (50%) and right (50%) colon. The majority of patients (63%) had early‐stage cancer.ConclusionsThe prevalence of PCCRC in a New Zealand cohort is consistent with other international reports. Most patients with PCCRC are older, female and have early‐stage disease. Of interest, a high proportion of patients developed cancer within a colonic segment with existent pathology, suggesting either missed lesions or incomplete polyp resection.
Atomically thin hydroxylation boron nitride nanosheets for excellent water‐based lubricant additives
Authors: Bai Yufeng , Wang Lixia , Ge Chunhua , Liu Rui , Guan Hongyu , Zhang Xiangdong 
Published: March 2020

AbstractHexagonal Boron nitride (BN) can be used as a lubricant additive, which can dramatically reduce friction energy. However, due to the accumulation of BN in the water‐based lubricants and the difficulty of entering the friction contact area, the tribological performance of BN becomes worse. To address this issue, the atomically thin hydroxylated boron nitride nanosheets (HO‐BNNS) were successfully prepared. The thickness of HO‐BNNS is only 0.6‐0.8 nm. Meanwhile, the HO‐BNNS has excellent dispersion stability in water‐based lubricants because of the hydroxyl group on the surface of HO‐BNNS. The as‐prepared HO‐BNNS exhibits unique friction properties as a water‐based dispersible lubricant additive. Additionally, the average wear scar diameter, average friction coefficient, and mean wear volume of HO‐BNNS/water‐based (0.05 wt%) drop by about 64.7%, 60%, and 95.73%. Finally, the introduction of HO‐BNNS can well control the temperature of water‐based lubricant.
Have SFAS 166 and SFAS 167 improved the financial reporting for securitizations?
Authors: Ahn Minkwan , Bonsall Samuel B. , Bozanic Zahn , Dou Yiwei , Richardson Gordon , Vyas Dushyantkumar 
Published: March 2020

AbstractCritics have alleged that securitization accounting prior to 2010 was among the causes of the recent financial crisis. In response to this criticism, the Financial Accounting Standards Board (FASB) implemented two new accounting standards, SFAS 166 and SFAS 167, to improve the financial reporting for securitizations. Bank regulators have stated their belief that SFAS 166/167 will result in a consolidated balance sheet (and risk‐based capital ratios based thereupon) that better reflects a bank's exposure to risk related to securitized assets. We document that, by ceding retained power or influence through the servicing/special servicing functions to third parties, SFAS 166/167 resulted in real effects to the extent that banks (particularly those that were weakly capitalized) achieved their accounting objectives in the post‐SFAS 166/167 period through legitimate transaction structuring in line with the intent of the new rules. Further, we use capital market participants’ assessments of risk retention by sponsoring banks as a benchmark, and provide evidence consistent with bank regulators’ beliefs. In particular, following SFAS 166/167, equity investors of sponsoring banks do not consider (consider) as risk relevant securitized assets that receive off‐balance sheet (on‐balance sheet) treatment. Securitized assets that are consolidated under SFAS 166/167 exhibit the same risk relevance as assets that are not securitized, despite contractual provisions that would seem to imply substantial risk transfer.
Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function
Authors: Wang Ding , Liu Nengqing , Xie Yingjun , Song Bing , Kong Shu , Sun Xiaofang 
Published: March 2020

AbstractMSCs are kind of cultured cells that reside in different tissues as inducers or regulators of physiological and pathological processes. Here, we derived MSCs from amniotic fluid and compared their differentiation ability and immunosuppression effect on PHA‐activated PBMC with those of MSCs isolated from umbilical cords. Amniotic fluid MSCs were isolated and cultured on commercial AFC medium and classic MSC medium, and the number and size of colonies were used to evaluate differences in primary and passaged culture. Rate of proliferation, population doubling time, cell morphology, cell surface markers and mRNA expression were measured in subcultured cells. Furthermore, a comparative study was performed with umbilical cord MSCs to assess the ability of differentiation and immunosuppressive effect of PHA‐stimulated PBMCs. Amniotic fluid MSCs were isolated and expanded by three methods, and exhibited nearly all the characteristics of umbilical cord MSCs. Compared with umbilical cord MSCs, amniotic fluid MSCs had an enhanced osteogenic and chrondrogenic differentiation capability, and stronger immunosuppression effect of inhibition of PHA‐activated PBMC division. Culture with commercial AFCs medium yielded the highest percentage of CD105 expression and showed some advantages in primary cell isolation, cell source‐specific marker retention and cell proliferation. We demonstrated that amniotic fluid MSCs exhibited some advantages over umbilical cord MSCs, and different culture media caused cell proliferation, cell surface marker and cell morphology change, but were not associated with varying differentiation capability and immune effects.
SARI prevents ocular angiogenesis and inflammation in mice
Authors: Zhang Wenqiu , Dai Lei , Li Xun , Li Yiming , Hung Yap Maurice Keng , Liu Longqian , Deng Hongxin 
Published: March 2020

AbstractSARI (Suppressor of AP‐1, regulated by IFN‐β) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin‐induced uveitis (EIU) and experimental argon laser‐induced choroidal neovascularization (CNV) model in SARI wild‐type (SARIWT) and SARI‐deficient (SARI−/−) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF‐positive cells were presented in the retina of SARI−/− mice with CNV. Compared to SARIWT mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI−/− mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization.
Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD: a prospective register‐based study
Authors: Du Rietz Ebba , Jangmo Andreas , Kuja‐Halkola Ralf , Chang Zheng , D'Onofrio Brian M. , Ahnemark Ewa , Werner‐Kiechle Tamara , Larsson Henrik 
Published: March 2020

BackgroundA better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally in individuals who continue to have ADHD‐related contact with health services (persisters) and those who do not (remitters).MethodsWe prospectively followed a cohort (N = 445,790) born 1987–1990 from the ages of 18 to 26 years. Data on healthcare utilization were obtained from the Swedish National Patient Register (inpatient and outpatient care) and the Prescribed Drug Register (medication prescriptions).ResultsMean annual costs per capita from multimorbidity was €890 ($1,223) in individuals with a childhood ADHD diagnosis (persisters/remitters: €1,060[$1,456]/€609[$837]) and €304 ($418) in individuals without. Costs were largely driven by inpatient hospital admissions, mainly from drug abuse and injuries. Healthcare utilization and costs of psychiatric and somatic disorders at 18 years was significantly higher in individuals with childhood ADHD compared to those without. These group differences remained stable or increased across young adulthood for most outcomes and were generally larger in women than in men. ADHD remitters continued to show significantly greater healthcare utilization and costs compared to individuals without childhood ADHD, although their profiles were not as severe as ADHD persisters.ConclusionsChildhood ADHD has long‐term associations with both psychiatric and somatic disorders. Findings demonstrate the individual and societal burden of ADHD in adulthood and highlight the importance of continued support from childhood–adolescent to adult health services and early prevention of multimorbidity. Findings also point to specific targets for intervention that may be effective, such as drug abuse and injuries.
Therapeutic management of adults with atopic dermatitis: comparison with psoriasis and chronic urticaria
Authors: Pascal C. , Maucort‐Boulch D. , Gilibert S. , Bottigioli D. , Verdu V. , Jaulent C. , Hacard F. , Bérard F. , Nicolas J.‐F. , Nosbaum A. 
Published: March 2020

AbstractBackgroundThe therapeutic options in atopic dermatitis rely on consensus‐based guidelines, also established for psoriasis and chronic urticaria. However, the therapeutic approach in atopic dermatitis, especially in the moderate‐to‐severe forms of the disease, seems less aggressive than in psoriasis and in chronic urticaria with a less frequent use of systemic agents.ObjectivesTo compare in real‐life conditions the therapeutic management of adults with atopic dermatitis with those with psoriasis and chronic urticaria.MethodsA transversal analysis was performed in May 2017, using retrospective data from a monocentric database. Data on epidemiology, severity, therapeutic educational intervention and systemic treatments were analysed from 401 patients with atopic dermatitis, compared with data from 230 patients with chronic urticaria and 535 patients with psoriasis.ResultsA high proportion (73%) of atopic dermatitis patients presented with a moderate‐to‐severe form of the disease compared to only 39% of chronic urticaria and 17% of psoriasis patients. Most of atopic dermatitis patients (78%) had completed a therapeutic educational programme, while the adherence was lower in chronic urticaria (35%) and in psoriasis (3%) patients. A systemic treatment, including biologicals, was recorded in 8% of atopic dermatitis patients, while it concerned 26% and 47% of chronic urticaria and psoriasis patients, respectively.ConclusionsWe confirmed that atopic dermatitis treatment mostly relies on topical treatments. Only a minority of moderate‐to‐severe atopic dermatitis patients who are eligible for a systemic treatment receive such therapy. This may suggest promoting a more frequent use of systemic agents in moderate‐to‐severe atopic dermatitis.
Malignant cutaneous tumours of the scalp: always remember to examine the head
Authors: Dika E. , Patrizi A. , Veronesi G. , Manuelpillai N. , Lambertini M. 
Published: March 2020

AbstractAround 2% of cutaneous neoplasms arise in the scalp (scalp tumours: STs). They can be classified as primary STs (epithelial, melanocytic and adnexal) or metastatic (from distal tumours or as a spreading from contiguous structures). This anatomic location is usually poorly examined during dermatological consultations, also due to the presence of the hair cover. Moreover, self‐examination of the hair‐covered skin is often harder for the patient. The peculiar features of the scalp may explain the worse prognosis of STs compared with neoplasms of other locations. The hair coverage protects the scalp from UV radiations, but due to the complex pathogenesis of STs, they may also develop in younger patients. Until now, STs have been not extensively investigated in the dermatological literature, and most publications are written by otolaryngologists, or by head, neck and plastic surgeons. Thus, dermatologists above all have the opportunity and the task to explore the scalp carefully, with the opportunity to make an early diagnosis, possibly changing the patient's prognosis. The aim of this paper was to review the main STs in order to increase awareness among dermatology specialists.
Evidence for Zoonotic Potential of Enterocytozoon bieneusi in Its First Molecular Characterization in Captive Mammals at Bangladesh National Zoo
Authors: Karim Md Robiul , Rume Farzana Islam , Rahman Abu Nasar Md Aminoor , Zhang Zhenjie , Li Junqiang , Zhang Longxian 
Published: March 2020

AbstractTo determine the occurrence and genotypes of Enterocytozoon bieneusi in captive mammals at Bangladesh National Zoo and to assess their zoonotic significance, 200 fecal samples from 32 mammalian species were examined using a nested PCR and sequencing of internal transcribed spacer (ITS) gene. Enterocytozoon bieneusi was detected in 16.5% (33/200) of the samples. Seven different ITS genotypes were identified, including two known genotypes (D and J) and five new ones (BAN4 to BAN8). Genotype D was the most common genotype being observed in 19 isolates. In phylogenetic analysis, four genotypes (D, BAN4, BAN5, and BAN6), detected in 30 isolates (90.9%), belonged to Group 1 having zoonotic potential. The sequence of genotype J found in a Malayan pangolin was clustered in so‐called ruminant‐specific Group 2. The other two genotypes BAN7 and BAN8 were clustered in primate‐specific Group 5. To our knowledge, this is the first report of molecular characterization of E. bieneusi in Bangladesh, particularly in captive‐bred wildlife in this country. The potentially zoonotic genotypes of E. bieneusi are maintained in zoo mammals that may transmit among these animals and to the humans through environmental contamination or contact.
Kinetic modeling on quality parameters of raw Kelulut honey during dehydration process
Authors: Yap Shu Khang , Chin Nyuk Ling 
Published: March 2020

AbstractAimsThe kinetics of Kelulut honey quality parameters of hydroxymethylfurfural (HMF), color intensity and total phenolic content (TPC) at dehydration temperatures of 40, 55, and 70°C up to 84 h were studied.MethodsData were fitted to zero‐, first‐, and second‐order kinetic models and regression analysis were performed to calculate rate constant and activation energy.ResultHMF increased following zero‐ and first‐order kinetics for 40 and 55°C, respectively. However, at 70°C, HMF first increased following zero‐order kinetics, peaked at 60 h and then decreased following first‐order kinetics. The color intensity of honey increased with dehydration time and was adequately described by zero‐order kinetics. The increase of TPC at lower dehydration temperature of 40 and 55°C followed zero‐order kinetics but at higher temperature of 70°C, was better fitted with first‐order model.ConclusionsThe rate constants for all quality parameters increased with dehydration temperature, indicating that changes were more evident at higher temperature. The increase of TPC was found to be more evident due to its lower activation energy of 54.79 kJ/mol as compared to 104.1 and 63.16 kJ/mol for the increase of HMF and color intensity, respectively.