bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling
Authors: Nakamura Tomoya , Yoshida Naoki , Yamanoi Yu , Honryo Akira , Tomita Hiroyuki , Kuwabara Hiroki , Kojima Yoshihiko 
Published: December 2020

AbstractEucalyptus oil has been used since ancient times for its bactericidal, anti-inflammatory, analgesic and sedative effects. In recent years, the action of Eucalyptus oil has been scientifically proven, and there have been reports that Eucalyptus oil suppresses the production of chemokines, cytokines and lipid mediators in basophils, alveolar macrophages and monocytes. Based on this information, we aimed to verify whether Eucalyptus oil can be used for allergic dermatitis, the incidence of which has been increasing among human skin diseases. This effect was verified using a mouse IgE-mediated local allergic model. In conclusion, topical application of Eucalyptus oil suppressed oedema and vascular permeability enhancement due to IgE-mediated allergic on the skin. In addition, we also verified the degranuration of mast cells, which is a part of its action, and examined whether 1,8-cineole, which is the main component of Eucalyptus oil, suppresses the phosphorylation of PLCγ and p38 directly or indirectly. 1,8-cineole was found to suppress degranulation of mast cells.
Analysis of recombinant proteins for Q fever diagnostics
Authors: Miller Halie K. , Kersh Gilbert J. 
Published: December 2020

AbstractSerology is essential for Q fever diagnostics, a disease caused by the bacterial pathogen Coxiella burnetii. The gold standard test is an immunofluorescence assay utilizing whole cell antigens, which are both dangerous and laborious to produce. Complexities of the antigen coupled with the subjective nature of the assay lead to decreased uniformity of test results and underscore the need for improved methodologies. Thirty-three C. burnetii proteins, previously identified as immunoreactive, were screened for reactivity to naturally infected goat serum. Based on reactivity, 10 proteins were analyzed in a secondary screen against human serum from healthy donors. Assay sensitivity and specificity ranged from 21 to 71% and 90 to 100%, respectively. Three promising antigens were identified based on receiver operating characteristic curve analysis (CBU_1718, CBU_0307, and CBU_1398). Five multiplex assays failed to outperform the individual proteins, with sensitivities and specificities ranging from 29 to 57% and 90 to 100%, respectively. Truncating the top antigen, CBU_1718, had no effect on specificity (90%); yet sensitivity decreased dramatically (71% to 21%). Through this study, we have expanded the subset of C. burnetii immunoreactive proteins validated by enzyme-linked immunosorbent assay and demonstrate the effect of novel antigen combinations and protein truncations on assay performance.
Plant growth promotion effect of plasma activated water on Lactuca sativa L. cultivated in two different volumes of substrate
Authors: Stoleru Vasile , Burlica Radu , Mihalache Gabriela , Dirlau Delicia , Padureanu Silvica , Teliban Gabriel-Ciprian , Astanei Dragos , Cojocaru Alexandru , Beniuga Oana , Patras Antoanela 
Published: December 2020

AbstractPlasma activated water (PAW) can represent an alternative to chemical fertilizers in agriculture. The effects of PAW treatment applied in two concentrations (1.5 or 3.0 mg L−1 NO3−) on some morphological, physiological, biochemical parameters and yield of Lactuca sativa L. grown in two different pot volumes (400 or 3200 cm3) were investigated in this study. The results showed that both PAW concentrations did not influence the germination, once the process was initiated. Positive effects of the treatments were registered on the length of radicle and hypocotyls of lettuce at a concentration of 1.5 mg L−1 NO3− (PAW I), the chlorophyll content was significantly increased at a concentration of 3.0 mg L−1 NO3− (PAW II) and bigger pot volume, also the foliar weight and area. No significant differences between the treated and untreated plants were recorded for the root weight, leaf length and width. The dry weight was significantly higher for the lettuce treated with PAW I and II grown in big volume pots at 57 days after transplanting (DAT) and small volume pots at 64 DAT. The nitrites content of the lettuce grown in big pots was lower than of the lettuce grown in small pots, regardless of the PAW treatment. Contrary, the nitrates content was higher in the lettuce grown in big pots (up to 36.4 mg KNO3/g DW), compared to small pots (under 0.3 mg KNO3/g DW).
Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China
Authors: Meng Xiao-Dan , Tong Yeqing , Wei Zhen-Ni , Wang Lei , Mai Jian-Yi , Wu Yang , Luo Zhi-Yu , Li Shaoping , Li Meng , Wang Siquan , Wei Sheng , Gong Wensheng , Zhang Wangsheng , Hu Xingzhou , Huang Jiao , Shi Jing , Yang Gang , Meng Shengli , Wang Zejun , Guan Xuhua , Shen Shuo 
Published: December 2020

AbstractCoxsackievirus A6 (CV-A6) and Coxsackievirus A10 (CV-A10) have been emerging as the prevailing serotypes and overtaking Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16) in most areas as main pathogens of hand, foot and mouth disease (HFMD) in China since 2013. To investigate whole etiological spectrum following EV-A71 vaccination of approximate 40,000 infants and young children in Xiangyang, enteroviruses were serotyped in 4415 HFMD cases from October 2016 to December 2017 using Real Time and conventional PCR and cell cultures. Of the typeable 3201 specimen, CV-A6 was the predominant serotype followed by CV-A16, CV-A10, CV-A5, CV-A2 and EV-A71 with proportions of 59.54%, 15.31%, 11.56%, 4.56%, 3.78% and 3.03%, respectively. Other 12 minor serotypes were also detected. The results demonstrated that six major serotypes of enteroviruses were co-circulating, including newly emerged CV-A2 and CV-A5. A dramatic decrease of EV-A71 cases was observed, whereas the total cases remained high. Multivalent vaccines against major serotypes are urgently needed for control of HFMD.
XG-ac4C: identification of N4-acetylcytidine (ac4C) in mRNA using eXtreme gradient boosting with electron-ion interaction pseudopotentials
Authors: Alam Waleed , Tayara Hilal , Chong Kil To 
Published: December 2020

AbstractN4-acetylcytidine (ac4C) is a post-transcriptional modification in mRNA which plays a major role in the stability and regulation of mRNA translation. The working mechanism of ac4C modification in mRNA is still unclear and traditional laboratory experiments are time-consuming and expensive. Therefore, we propose an XG-ac4C machine learning model based on the eXtreme Gradient Boost classifier for the identification of ac4C sites. The XG-ac4C model uses a combination of electron-ion interaction pseudopotentials and electron-ion interaction pseudopotentials of trinucleotide of the nucleotides in ac4C sites. Moreover, Shapley additive explanations and local interpretable model-agnostic explanations are applied to understand the importance of features and their contribution to the final prediction outcome. The obtained results demonstrate that XG-ac4C outperforms existing state-of-the-art methods. In more detail, the proposed model improves the area under the precision-recall curve by 9.4% and 9.6% in cross-validation and independent tests, respectively. Finally, a user-friendly web server based on the proposed model for ac4C site identification is made freely available athttp://nsclbio.jbnu.ac.kr/tools/xgac4c/.
Harvesting energy from sun, outer space, and soil
Authors: Tian Yanpei , Liu Xiaojie , Chen Fangqi , Zheng Yi 
Published: December 2020

AbstractWhile solar power systems have offered a wide variety of electricity generation approaches including photovoltaics, solar thermal power systems, and solar thermoelectric generators, the ability to generate electricity at both the daytime and nighttime with no necessity of energy storage remains challenging. Here, we propose and verify an environment-friendly, sustainable, and cost-effective strategy of harvesting solar energy by solar heating during the daytime and harnessing the coldness of the outer space through radiative cooling to produce electricity at night using a commercial thermoelectric module. It enables electricity generation for 24 h a day. We experimentally demonstrate a peak power density of 37 mW/m$$^2$$

2

at night and a peak value of 723 mW/m$$^2$$

2

during the daytime. A theoretical model that accurately predicts the performance of the device is developed and validated. The feature of 24-h electricity generation shows great potential energy applications of off-grid and battery-free lighting and sensing.
Dual solutions of nanomaterial flow comprising titanium alloy (Ti6Al4V) suspended in Williamson fluid through a thin moving needle with nonlinear thermal radiation: stability scrutinization
Authors: Khan Umair , Zaib A. , Khan Ilyas , Nisar Kottakkaran Sooppy 
Published: December 2020

AbstractTitanium alloy nanoparticle has a variety of applications in the manufacturing of soap and plastic, microsensors, aerospace design material, nano-wires, optical filters, implantation of surgical, and many biological treatments. Therefore, this research article discussed the influence of nonlinear radiation on magneto Williamson fluid involving titanium alloy particles through a thin needle. The arising system of partial differential equations is exercised by the similarity transformations to get the dimensional form of ordinary differential equations. The dual nature of solutions is obtained by implementing bvp4c. The study of stability has been carried out to check which of the results are physically applicable and stable. Influences of pertinent constraints on the flow field are discussed with the help of graphical representations and the method validation is shown in Table 1. The results imply that more than one result is established when the moving needle and the free-stream travel in the reverse directions. Moreover, the magnetic parameter accelerates the severance of boundary-layer flow, while the separation delays in the absence of the nanoparticle. The velocity gradient of nanofluid decays owing to the Williamson parameter in both branches of the outcome, while the temperature shrinks in the first or upper branch solution (stable one) and uplifts in the second or lower branch solution (unstable one). The size of the needle decreases the velocity in the upper solution and accelerates in the lower solution. The patterns of streamlines are more complicated due to the reverse direction of the free stream and thin needle.
Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials
Authors: Aghamohammadi Dawood , Dolatkhah Neda , Bakhtiari Fahimeh , Eslamian Fariba , Hashemian Maryam 
Published: December 2020

AbstractThis study designed to evaluate the effect of nutraceutical supplementation on pain intensity and physical function in patients with knee/hip OA. The MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, Google Scholar, Science direct, and ProQuest in addition to SID, Magiran, and Iranmedex were searched up to March 2020. Records (n = 465) were screened via the PICOS criteria: participants were patients with hip or knee OA; intervention was different nutritional supplements; comparator was any comparator; the outcome was pain intensity (Visual analogue scale [VAS]) and physical function (Western Ontario and McMaster Universities Arthritis [WOMAC] index); study type was randomized controlled trials. The random effects model was used to pool the calculated effect sizes. The standardized mean difference (SMD) of the outcome changes was considered as the effect size. The random effects model was used to combine the effect sizes. Heterogeneity between studies was assessed by Cochran's (Q) and I2 statistics. A total of 42 RCTs were involved in the meta-analysis. Nutritional supplementation were found to improve total WOMAC index (SMD = − 0.23, 95% CI − 0.37 to − 0.08), WOMAC pain (SMD = − 0.36, 95% CI − 0.62 to − 0.10) and WOMAC stiffness (SMD = − 0.47, 95% CI − 0.71 to − 0.23) subscales and VAS (SMD = − 0.79, 95% CI − 1.05 to − 0.05). Results of subgroup analysis according to the supplementation duration showed that the pooled effect size in studies with < 10 months, 10–20 months and > 20 months supplementation duration were 0.05, 0.27, and 0.36, respectively for WOMAC total score, 0.14, 0.55 and 0.05, respectively for WOAMC pain subscale, 0.59, 0.47 and 0.41, respectively for WOMAC stiffness subscale, 0.05, 0.57 and 0.53, respectively for WOMAC physical function subscale and 0.65, 0.99 and 0.12, respectively for VAS pain. The result suggested that nutraceutical supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and physical function.
Grid balancing with a large‐scale electrolyser providing primary reserve
Authors: Samani Arash E. , D'Amicis Anna , De Kooning Jeroen D.M. , Bozalakov Dimitar , Silva Paolo , Vandevelde Lieven 
Published: December 2020

As the share of renewable energy sources increases, the grid frequency becomes more unstable. Therefore, grid balancing services will become more important in the future. Dedicated devices can be installed close to the point where off‐shore wind farms are connected to the transmission grid on land. There, they can be used to attenuate power variations, reduce congestion and offer grid balancing. The provision of these ancillary services can create considerable additional economic revenue. In this study, the provision of the primary reserve by means of a large hydrogen electrolyser of 25 MW is investigated for the specific case of the Belgian transmission system. The revenue of the provision of the frequency containment reserve (FCR) is analysed on a techno‐economic model, including capital costs, operational costs, the revenue of the generated hydrogen and oxygen products and the ancillary service income. The revenue depends strongly on the contracted power band. Therefore, it is optimised to yield maximum revenue. The results show that providing FCR creates considerable additional revenue. Therefore, a large electrolyser can be a good candidate to buffer excess renewable energy into green gas while simultaneously providing the grid support.
Analysis of Surgical Recurrence after Larynx Microsurgery for Benign Lesions
Authors: Patrial Maria Theresa Costa Ramos de Oliveira , Hamerschmidt Rogério , Matias Jorge Eduardo Fouto , Filho Evaldo Dacheux de Macedo , Carvalho Bettina 
Published: December 2020

Abstract
Introduction The study of larynx lesions is of great importance. More than 50% of people with vocal complaints have benign vocal fold alterations and some require surgery.
Objective To determine which factors are related to surgical recurrence of benign laryngeal lesions and to determine which videolaryngoscopic diagnoses are related to the risk or protection of surgical relapses over time.
Methods Observational, analytical, cross-sectional study with retrospective data collection of 1,383 surgeries in 1,301 patients.
Results The mean age at the first surgery was 39.2 years old. The predominant gender was female (65.6%).There were 396 cases of polyps (25.34%), 349 cases of cysts (22.33%), 261 cases of Reinke edema (16.7%), 175 cases of nodules (11.2%), 153 cases of minor structural alterations (MSAs) (9.79%), 94 cases of leukoplakia (6.01%), 77 cases of granulomas (4.93%) and 58 cases of pseudocysts (3.71%). The age presented statistical significance with the risk of surgical relapses (p = 0.016). Male gender was associated with the greatest chance of relapse.Diagnosis of granuloma (p < 0.001) and of leukoplakia (p < 0.001) were associated with a higher risk of surgical recurrence. Cyst diagnosis was associated with protection (p = 0.015) in relation to the chance of further surgeries. Patients with associated lesions, bilaterals or voice professionals did not present a statistically significant association with surgical recurrence.
Conclusion Age and gender are statistically related to the increase of surgical relapses. Leukoplakia and granuloma are associated with increased surgical relapses. Patients submitted to cyst microsurgery appear to be protected against surgical recurrence.
Linguistic categories, language description and linguistic typology – An overview
Authors: Alfieri Luca , Arcodia Giorgio Francesco , Ramat Paolo 
Published: December 2020

In this paper we propose a critical discussion of the rationale for this volume. After a short introduction (Section 1), an outline of the long-standing opposition between language particular description and universal grammar in the history of the language sciences is provided (Section 2). This opposition indeed represents the substrate on which our ‘comparative concepts debate’ is based: a summary of the debate, both in the form it had in the lingtyp mailing list (January / February 2016) and in the subsequent monographic issue of Linguistic Typology 2016, is offered in Section 3 and Section 4. Some critical consideration on the debate and on its relation with the various branches of linguistics are presented in Section 5. An overview of the papers included in the volume closes this introduction (Section 6).
Greater decrements in neuromuscular function following interval compared to continuous eccentric cycling
Authors: Green David James , Thomas Kevin , Howatson Glyn 
Published: December 2020

Our aim was to determine the demands and consequences of a single session of continuous (CONT) or interval (INT) eccentric cycling. Fourteen healthy males performed ‘work‐matched’ CONT and INT eccentric cycling in a cross over design. Measures of maximal voluntary contraction (MVC), resting twitch force, voluntary activation (VA), muscle soreness and creatine kinase (CK) were taken at baseline, immediately post, and 24, 48 and 72 h post the first exercise bout. The second bout was used to characterise within session demands. Decreases in MVC (INT 19%, CONT 13%), twitch force (INT 31%, CONT 18%), and VA (INT 10%, CONT 6%) were observed immediately post session (p < 0.05). Reductions in twitch force were greater after INT (p < 0.05) and lasted 48 h. Muscle soreness was greater following INT, versus CONT (p < 0.05), although no differences in CK were observed. Metabolic demands (% of V̇O2peak and [BLa]) were greater during INT vs. CONT (32 ± 6% 28 ± 6%; p < 0.001), [BLa] (1.0 ± 0.4 vs. 0.8 ± 0.2 mmol·L−1; p < 0.001) and RPE (12 ± 1 vs. 11 ± 1; p < 0.001), respectively. Total time under tension was 48% greater in CONT compared to INT (p < 0.001), whereas average torque (during exercise) was 40% greater during INT compared to CONT (p < 0.001). Interval eccentric cycling exacerbates muscle soreness, decrements in muscle function and lengthens recovery compared to a work matched continuous bout, which is attributable to increased force rather than time under tension.
“Surface-line-point”—analysis of the development of artificial intelligence in the Yangtze River Delta
Authors: Liang Yao , Hu Yuewei 
Published: December 2020

Abstract
Artificial intelligence technology is booming all over the world, profoundly affecting the social and economic development model and people’s lifestyle. The Yangtze River Delta urban agglomeration, which has a very high strategic position in the country’s modernization and comprehensive opening up, is an important support for China’s participation in international competition and a gathering place for China’s cutting-edge technology. The Yangtze River Delta has become the leader of my country’s artificial intelligence technology and industry by virtue of its advantageous geographical location, active economic development, high-density talent pool and years of development and accumulation in the field of artificial intelligence. From “surface-line-point”, the article analyzes the advantages and disadvantages of the rapid development of artificial intelligence in the Yangtze River Delta; combines the education industry to analyze the integration of artificial intelligence and education and possible bottlenecks; conforms to the trend of the times and shows the new Internet celebrities of programming world—python.
The Application Research of Artificial Intelligence and Big Data Analysis Technology in University Foreign Language Teaching
Authors: Zhang Xinyan 
Published: December 2020

Abstract
In recent years, with the development of computer linguistics and artificial intelligence technology in the field of English education, the research methods and technical means of artificial intelligence big data analysis have been introduced into the research and practice of foreign language teaching. As a new element, artificial intelligence big data analysis provides a new approach and research perspective for foreign language teaching. In order to solve the problems of foreign language teaching resources sharing, optimizing teaching resources, improve the efficiency of foreign language topic teaching, and improving the interaction between teachers and students, based on the theoretical and practical research of foreign language teaching in colleges and universities, this paper uses artificial intelligence and big data technology, firstly classifies the artificial intelligence system of foreign language teaching in colleges and universities, secondly, it classifies the information technology of artificial intelligence in high school. The ability of information storage and information processing in college foreign language teaching is analyzed theoretically in computer language. The software and hardware design of the artificial intelligence information integrated system of college foreign language teaching is carried out. The results show that: relying on the design of the storage module and system server, the hardware design of the system is realized, and the software design of the system is realized based on the system running environment design and database design. Finally, the paper puts forward the countermeasures and suggestions for the development of AI in foreign language teaching.
Research on classification of spiral galaxies and stars based on convolutional neural network
Authors: Xu Zhaoyan , Hu Tao , Peng Zhongqi 
Published: December 2020

Abstract
In astronomy, the shape of galaxies can often reflect the course of its evolution, and can further reveal the development law of the universe. With the progress and development of observation technology, image data has grown explosively, and the efficiency of traditional manual astronomical image classification is far from enough. Image classification based on machine learning effectively solves the problem of low efficiency of artificial classification, but in the face of massive data sets, the classification effect of traditional machine learning is often not as good as deep learning. In this paper, relevant concepts based on neural network image classification algorithm are introduced. Then, according to the characteristics of the mainstream CNN (convolutional neural network) model, the design and optimization of the custom RS CNN model are completed. Finally, the custom RS CNN is used to conduct classification experiments on spiral galaxies and stars.
Hardware Trojan detection research based on MLP
Authors: Ding Qiao , Yin Shizhuang , Liu Lijun , Wang Chao 
Published: December 2020

Abstract
In view of the variety of Hardware Trojan (HT) and the difficulty of obtaining unknown Trojan characteristics in side-channel signals by conventional methods. In this paper, MLP was selected to establish the network model by means of supervised learning, the method took supervised learning ways to build neural network model for feature extraction and discrimination of side channel information. A verification system was set up based on FPGA to obtain side-channel information. The results show that the detection rate of the MLP is more than 1% higher than that of the traditional support vector machine (SVM) method when detecting the hardware Trojan horse with the parent circuit area of 2%.