bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey Analysis on TV Viewers: Unethical Issues in Telugu Drama Serials
Authors: Babu J. Madhu , Krishna K. M. M. 
Published: August 2020

Television in India has proven a most influential infotainment media powerful and popular among its audience. Television plays a vital role in the telecast entertaining program. Fiction has been a popular genre on Indian Television. A common habit among most of the Indian families is watching drama serials in the evening as one of the best time-pass activities i.e. why serials have become part and parcel of most of its viewer's lives. TV drama serials have become one of the most popular offerings. It affects people irrespective of gender, age, and other demographic variables. The study was conducted to throw light towards various Television viewing habits among the Telugu audience. A sample of 316 respondents from Amravati the new capital of the newly formed state of Andhra Pradesh was selected for survey analysis. Structured questioners were distributed to them and the responses were collected. A Chi-square test is used to analyze the collected data. The study also highlighted the opinions of viewers on Telugu drama serials. Focused group discussions have been conducted.
Efektivitas Penggunaan Alat Peraga Lidi Terhadap Hasil Belajar Matematika Ditinjau dari Motivasi Belajar Siswa pada Materi Menggambar Vektor
Authors: Widiyastuti Wahyuning 
Published: August 2020

<p class="06IsiAbstrak">Penelitian ini merupakan penelitian eksperimen yang bertujuan untuk menguji keefektifan penggunaan alat peraga lidi dan motivasi siswa terhadap pembelajaran matematika dalam rangka meningkatkan hasil belajar matematika. Subyek penelitian adalah siswa kelas X MIPA SMA Negeri 2 Kudus yang berjumlah 72 orang dan terbagi dalam dua kelompok penelitian. Kedua kelompok mengalami perlakuan yang sama secara bergantian. Metode penelitian yang digunakan adalah counter balance. Teknik pengumpulan data hasil belajar dilakukan melalui pretest dan postest. Sedangkan pengumpulan data motivasi dilakukan melalui teknik angket. Hasil penelitian menunjukkan bahwa terdapat perbedaan hasil belajar matematika antar siswa yang diajar dengan menggunakan alat peraga lidi dan siswa yang diajar dengan tanpa menggunakan alat peraga lidi dengan nilai F = 12,434 untuk Kelompok siswa yang diajar dengan menggunakan alat peraga lidi mempunyai hasil belajar yang lebih tinggi. Hasil penelitian juga menunjukkan bahwa terdapat perbedaan hasil belajar antara siswa yang mempunyai motivasi belajar tinggi dan siswa yang mempunyai motivasi belajar rendah dengan nilai F = 61,678 untuk Hasil belajar yang lebih baik ditunjukkan oleh kelompok siswa yang memiliki motivasi belajar tinggi. Selanjutnya, hasil penelitian juga menunjukkan bahwa tidak ada interaksi antara penggunaan alat peraga lidi dan tanpa penggunaan alat peraga lidi dengan motivasi siswa dalam meningkatkan hasil belajar matematika. Hasil ini diperlihatkan oleh nilai F = 0,103 untuk Beda rata – rata pre test dan post test antara kelompok yang menggunakan alat peraga lidi dan kelompok yang lain adalah 57,917. Pada kelompok yang menggunakan alat peraga lidi dengan motivasi rendah menunjukkan bahwa alat peraga lidi dapat meningkatkan motivasi siswa dalam pembelajaran matematika. Hasil penelitian juga menyimpulkan bahwa penggunaan alat peraga lidi terbukti efektif meningkatkan hasil belajar matematika siswa pada materi menggambar vektor dimensi tiga.</p>
Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis
Authors: xu hanyue , Qin Ling , Zhang Yifan , Xiao Yinan , Zhang Ming 
Published: August 2020

Abstract
Purpose: Given the two different kind of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery. Method: Publications up to July 2020 that compared the surgical outcomes of LMH patients with and without LHEP were included. Forest plots were created by using a weighted summary of proportion meta-analysis. Fixed or random effects models were used based on I2 heterogeneity estimates. Meanwhile, to evaluate the stability of the meta-analysis, sensitivity analysis was carried out.Result: Eight pertinent publications were included, which contained a total of 176 eyes without LHEP and 173 eyes with LHEP. They were all retrospective studies and had a follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity (BCVA) had no significant differences between the two groups and improved in both groups after surgery. Pooled results of the improved BCVA was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01) between the with and without LHEP groups. The odds ratio of restored ellipsoid zone (REZ) was 0.80 (95% CI, 0.26 to 2.44; p = 0.69) among the group with LHEP and without LHEP.In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups.
Identification of a quantitative trait loci (QTL) associated with ammonia tolerance in the Pacific white shrimp (Litopenaeus vannamei)
Authors: Zeng Digang , Yang Chunling , Li Qiangyong , Zhu Weilin , Chen Xiuli , Peng Min , Chen Xiaohan , Lin Yong , Wang Huanling , Liu Hong , Liang Jingzhen , Liu Qingyun , Zhao Yongzhen 
Published: August 2020

Abstract
Background: Ammonia is one of the most common toxicological environment factors affecting shrimp health. Although ammonia tolerance in shrimp is closely related to successful industrial production, few genetic studies of this trait are available. Results: In this study, we constructed a high-density genetic map of the Pacific white shrimp (Litopenaeus vannamei) using specific length amplified fragment sequencing (SLAF-seq). The constructed genetic map contained 17,338 polymorphic markers spanning 44 linkage groups, with a total distance of 6,360.12 centimorgans (cM) and an average distance of 0.37 cM. Using this genetic map, we identified a quantitative trait locus (QTL) that explained 7.41–8.46% of the phenotypic variance in L. vannamei survival time under acute ammonia stress. We then sequenced the transcriptomes of the most ammonia-tolerant and the most ammonia-sensitive individuals from each of four genetically distinct L. vannamei families. We found that 7546 genes were differentially expressed between the ammonia-tolerant and ammonia-sensitive individuals. Using QTL analysis and the transcriptomes, we identified one candidate gene (annotated as an ATP synthase g subunit) associated with ammonia tolerance. Conclusions: In this study, we constructed a high-density genetic map of L. vannamei and identified a QTL for ammonia tolerance. By combining QTL and transcriptome analyses, we identified a candidate gene associated with ammonia tolerance. Our work provides the basis for future genetic studies focused on molecular marker-assisted selective breeding.
Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies
Authors: Ayenew Wondim , Asmamaw Getahun , Issa Arebu 
Published: August 2020

Abstract
Background: Drug-drug interaction is an emerging threat to public health. Currently, there is an increase in comorbid disease, polypharmacy, and hospitalization in Ethiopia. Thus, the possibility of drug-drug interaction occurrence is high in hospitals. This study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals.Methods: A literature search was performed by accessing legitimate databases in PubMed/MEDLINE, Google Scholar, and Research Gate for English-language publications. To fetch further related topics advanced search was also applied in Science Direct and HINARI databases. The search was conducted on August 3 to 25, 2019. All published articles available online until the day of data collection were considered. Outcome measures were analyzed with Open Meta Analyst and CMA version statistical software. Der Simonian and Laird’s random effect model, I2 statistics, and Logit event rate were also performed.Results: A total of 14 studies remained eligible for inclusion in systematic review and meta-analysis. From the included studies, around 8,717 potential drug-drug interactions were found in 3,259 peoples out of 5,761 patients. The prevalence of patients with potential drug-drug interactions in Ethiopian hospitals was found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of major, moderate, and minor potential drug-drug interaction was 25.1%, 52.8%, 16.9%, respectively, also 1.27% for contraindications. The factors associated with potential drug-drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease, and hospital stay.Conclusions: There is a high prevalence of potential drug-drug interactions in Ethiopian hospitals. Polypharmacy, age, comorbid disease, and hospital stay were the risk factors associated with potential drug-drug interactions.
Ovarian metastasis from nongynecologic primary sites: a retrospective analysis of 177 cases and 13-year experience
Authors: Zhang Jing-Jing , Cao Dong-Yan , Yang Jia-Xin , Shen Keng 
Published: August 2020

Abstract
Background: Metastasis to the ovary from nongynecologic organs accounts for 9% of all ovarian malignancies. Although the most common nongynecologic primary site of ovarian metastasis is the gastrointestinal tract, metastasis from other sites to the ovary is not uncommon. Differential diagnosis of primary and metastatic ovarian tumors is important; otherwise, appropriate treatment cannot be determined. Furthermore, an optimal treatment strategy for ovarian metastasis from nongynecologic primary sites still needs to be explored.Methods: One hundred seventy-seven patients with ovarian metastasis from nongynecologic primary sites admitted to Peking Union Medical College Hospital between May 2005 and May 2018 were retrospectively evaluated.Results: The mean age was 48 years (range, 18 - 83). Approximately 60% of patients were premenopausal women. The two most common nongynecologic primary sites of ovarian metastasis were the colorectum (68 cases) and stomach (61 cases). In addition to the most common symptoms of abdominal distension (39.0%), abdominal pain (37.9%), and ascites (27.7%), 18.1% of patients presented with abnormal uterine bleeding. Half of the patients who tested serum CA-125 preoperatively had elevated CA-125 levels within the range of 35 U/ml to 200 U/ml. More than 70% of synchronous ovarian metastases were preoperatively misdiagnosed as primary ovarian cancer. Of all included cases, 56.5% achieved optimal cytoreductive surgery (the diameter of the largest residual lesion < 2 cm). The overall 5-year survival rate and median survival time were 10% and 20 months, respectively. The primary site, optimal cytoreductive surgery, tumor differentiation, and postoperative adjuvant treatment were identified as prognostic indicators.Conclusions: The colorectum and stomach are the most common nongynecologic primary sites of ovarian metastasis. Synchronous ovarian metastasis is easily misdiagnosed as primary ovarian cancer. Optimal cytoreductive surgery and postoperative adjuvant treatment can be performed to confer survival benefit in selected patients.
Uterine Transcriptome Analysis Reveals Mechanism Underlying the Ultrastructure Differences of Eggshell in Young and Aged Laying Hens
Authors: Feng Jia , Zhang Hai-jun , Wu Shu-geng , Qi Guang-hai , Wang J. 
Published: August 2020

Abstract
Background

Lower eggshell quality in the late laying period leads to economic loss. It is a major threat to the quality and safety of egg products. Age-related variations in ultrastructure were thought to induce this deterioration. Eggshell mineralization is a highly complex process under precise regulation of genes and biological pathways in uterus of laying hens. Herein, we evaluated the physical, mechanical and ultrastructure properties of eggshell and conducted RNA sequencing to learn the transcriptomic differences in uterus between laying hens in the peak (young hens) and late phase (aged hens) of production.

Results

The declined breaking strength and fracture toughness of eggshell were observed in aged hen group compared to those in young hen group, accompanied with ultrastructure variations including the increased thickness of mammillary layer and the decreased incidence of early fusion. During the initial stage of eggshell formation, a total of 183 differentially expressed genes (DEGs; 125 upregulated and 58 downregulated) were identified in uterus of laying hens in the late phase in relative to those at peak production. The DEGs annotated to Gene Ontology terms related to antigen processing and presentation were downregulated in aged hens compared to young hens. The contents of proinflammatory cytokine IL-1β in uterus were higher in aged hens relative to those in young hens. Besides, the genes of some matrix proteins potentially involved in eggshell mineralization, such as ovalbumin, versican and glypican 3, were also differentially expressed between two groups.

Conclusions

Altered gene expression of matrix proteins along with the compromised immune function in uterus of laying hens in the late phase of production may conduce to age-related impairments of eggshell ultrastructure and mechanical properties. The current study enhances our understanding of the age-related deteriorations in eggshell ultrastructure and provides potential targets for improvement of eggshell quality in the late laying period.
The morphological changes in bitches endometrium affected by Cystic Endometrail Hyperplasia - Pyometra complex – the value of routine histopathological examination
Authors: Woźna-Wysocka Magdalena , Rybska Marta , Błaszak Beata , Jaśkowski Bartłomiej Maria , Kulus Magdalena , Jaśkowski Jędrzej Maria 
Published: August 2020

Abstract
Background: The aim of the analysis was to designate the morphological symptoms that appear during the Cystic Endometrial Hyperplasia - Pyometra complex (CEH-P), diagnosed by microscopic examination. The investigation were conducted on the uteri of 120 bitches in age between 1 – 16. The microscopic examinations were based on histological stainings. The aim of examinations was to find the differences in morphology of endometrium in the specimens of the uteri wall (H&E stain). All of the uteri were divided into three pathological groups (GI – GIII), created on the basis of macroscopic examinations of analyzed diseases. Uteri without macroscopic pathological changes were classified as a control group (C).Results: Histopathological analysis that were conducted have confirmed preliminary macroscopic evaluation for control group with unchanged uteri, group GII with cystic endometrial hyperplasia of uteri (CEH), and group GIII with uteri with pyometra. The confirmation of compatibility of both macroscopic and microscopic evaluation of the uteri were observed in groups GII and GIII. In the uteri of the group GI a severe congestion of endometrium have been observed – it is typical for the inflammation – which was not confirmed during histopathological examinations. Those examinations revealed only endometrial haemorrhage.Conclusions: The results are showing that during classification of research material microscopic examinations are required. The diagnose based on the macroscopic changes in typical for CEH-P symptoms might be incorrect, if it is not supported by detailed research. More than that, in all uteri with the closed pyometra the CEH was also observed. It suggest that pyometra may occur as a consequence of cystic endometrial hyperplasia and bacterial infections ended with inflammation. The results obtained can be used to create a basis for pathologic classification of endometrial hyperplasia and indicate typical morphological changes in endometrium during development of CEH-P complex in bitches.
Role of Interprofessional Primary Care Teams in Preventing Avoidable Hospitalizations and Hospital Readmissions in Ontario, Canada: A Retrospective Cohort Study
Authors: Haj-Ali Wissam , Moineddin Rahim , Hutchison Brian , Wodchis Walter P , Glazier Richard H. 
Published: August 2020

Abstract
Background: Improving health system value and efficiency are considered major policy priorities internationally. Ontario has undergone a primary care reform that included introduction of interprofessional teams. The purpose of this study was to investigate the relationship between receiving care from interprofessional versus non-interprofessional primary care teams and ambulatory care sensitive condition (ACSC) hospitalizations and hospital readmissions. Methods: Population-based administrative databases were linked to form data extractions of interest between the years of 2003-2005 and 2015-2017 in Ontario, Canada. The data sources were available through ICES. The study design was a retrospective longitudinal cohort. We used a “difference-in-differences” approach for evaluating changes in ACSC hospitalizations and hospital readmissions before and after the introduction of interprofessional team-based primary care while adjusting for physician group, physician and patient characteristics. Results: As of March 31 st , 2017, there were a total of 778 physician groups, of which 465 were blended capitation Family Health Organization (FHOs); 177 FHOs (22.8%) were also interprofessional teams and 288 (37%) were more conventional group practices (“non-interprofessional teams”). In this period, there were a total of 13,480 primary care physicians in Ontario of whom 4,848 (36%) were affiliated with FHOs—2,311 (17.1%) practicing in interprofessional teams and 2,537 (18.8%) practicing in non-interprofessional teams. During that same period, there were 475,611 and 618,363 multi-morbid patients in interprofessional teams and non-interprofessional teams respectively out of a total of 2,920,990 multi-morbid adult patients in Ontario. There was no difference in change over time in ACSC admissions between interprofessional and non-interprofessional teams between the pre- and post intervention periods. There were no statistically significant changes in all cause hospital readmission s between the post- and pre-intervention periods for interprofessional and non-interprofessional teams. Conclusions: Our study findings indicate that the introduction of interprofessional team-based primary care was not associated with changes in ACSC hospitalization or hospital readmissions. The findings point for the need to couple interprofessional team-based care with other enablers of a strong primary care system to improve health services utilization efficiency.
Mid-term Outcome of Total Knee Arthroplasty with Low-restricted Posterior-stabilized Prosthesis in Patients with Severe Fixed Valgus Deformity: A Case-Control Study
Authors: Gou Jiani , Shi Xiaojun , Liu Senhao , Yang Jing , Kang Pengde 
Published: August 2020

Abstract
Background: The intraoperative soft tissue balance in primary total knee arthroplasty (TKA) is particularly difficult to perform in patients with severe fixed valgus deformity above 20°, which may have an adverse effect on clinical outcomes. The purpose of our study was to determine whether the TKA with low-restricted posterior-stabilized prosthesis in patients with severe fixed valgus deformity could be as successful as in those with no preoperative deformities by comparing perioperative evaluations and mid-term outcomes.Methods: 45 patients (group A) with severe valgus deformity were treated by TKA with low-restricted posterior- stabilized knee prosthesis; 90 patients (group B) without severe valgus deformity were treated with same surgery and were classified to match the cases in group A. The perioperative evaluations, clinical and radiographic outcomes were compared between the two groups. The postoperative stability was measured by the Kneelax 3 Arthrometer.Results: The mean follow-up time was 7.64 years. There was no significant difference in age, gender, BMI between the two groups. There was no revision for any reason in either group. The mean operation time and blood transfusion rate were 114 minutes and 46.7% in group A, while 81 minutes and 11.1% in group B, respectively. There were significant differences in both parameters between the two groups (p<0.001). The incidence of residual valgus in group A was 20% and the complication rate was 22.2%, while 3.3% and 4.4% in group B, respectively. The incidence of residual valgus and the complication rate was significantly higher in group A than in group B (p=0.004). However, there was no statistical difference in Hospital for Special Surgery (HSS) score, range of motion, component fixation, or knee stability at the most recent follow-up. Conclusion: Although total knee arthroplasty for severe fixed valgus deformity increases the difficulty of operation and the complication rate in perioperative period, low-restricted posterior-stabilized knee prosthesis with proper alignment and soft tissue balance can have satisfactory mid-term outcomes. Level of evidence: Case-control study, Level III.
Efficacy of non-opioid analgesics to control postoperative pain: A network meta-analysis
Authors: Carter John A , Black Libby K , Sharma Dolly , Bhagnani Tarun , Jahr Jonathan 
Published: August 2020

Abstract
BACKGROUND The aim of this network meta-analysis (NMA) was to evaluate the safety and efficacy of intravenous (IV) Meloxicam 30mg (MIV), an investigational non-steroidal anti-inflammatory drug (NSAID), and certain other IV non-opioid analgesics for moderate-severe acute postoperative pain. METHODS We searched PubMed and CENTRAL for Randomized Controlled Trials (RCT) (years 2000-2019, adult human subjects) of IV non-opioid analgesics (IV NSAIDs or IV Acetaminophen) used to treat acute pain after abdominal, hysterectomy, bunionectomy or orthopedic procedures. A Bayesian NMA was conducted in STATA (v15.0) to rank treatments based on the standardized mean differences in sum of pain intensity difference from baseline up to 24 hours postoperatively (Sum of pain intensity difference: SPID 24). The probability and the cumulative probability of rank for each treatment were calculated, and the surface under the cumulative ranking curve (SUCRA) was applied to distinguish each treatment by efficacy and safety where higher SUCRA values indicated better outcomes. Treatments were also compared by frequency of opioid-related adverse events (ORADEs) including gastrointestinal and respiratory and reduction in morphine milligram equivalents (MME). The study protocol was prospectively registered with by PROSPERO (CRD42019117360). RESULTS Out of 2,313 screened studies, 27 studies with 36 comparative observations were included, producing a treatment network that included the four non-opioid IV pain medications of interest (MIV, ketorolac, acetaminophen, and ibuprofen). MIV was associated with the largest SPID 24 for all procedure categories and comparators. The SUCRA ranking table indicated that MIV had the highest probability for the most effective treatment for abdominal (89.5%), bunionectomy (100%), and hysterectomy (99.8%). Significantly lower MME was associated with MIV for abdominal (vs acetaminophen, ibuprofen and ketorolac), bunionectomy (vs acetaminophen), hysterectomy (vs acetaminophen and ketorolac) and orthopedic procedures (vs acetaminophen and ibuprofen). Odds of ORADEs were significantly higher for all comparators vs MIV for orthopedic (gastrointestinal) and hysterectomy (respiratory). CONCLUSIONS MIV 30mg may provide better pain reduction with similar or better safety compared to other approved IV non-opioid analgesics. Caution is warranted in interpreting these results, as all comparisons involving MIV were indirect.