bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension
Authors: Kmeid Michel , Zuo Chunlai , Lagana Stephen M. , Choi Won-Tak , Lin Jingmei , Yang Zhaohai , Liu Xiuli , Westerhoff Maria , Fiel M. Isabel , Affolter Kajsa , Choi Eun-Young K. , Lee Hwajeong 
Published: October 2020

Abstract
Background
Histologic features of idiopathic non-cirrhotic portal hypertension (INCPH) may overlap with those without INCPH. Recently, these features have been recognized as part of the larger spectrum of porto-sinusoidal vascular disease (PSVD). We assessed interobserver agreement on histologic features that are commonly associated with INCPH and studied whether a provision of relevant clinical history improves interobserver agreement.

Methods
The examined histologic features include lobular (such as anisocytosis, nodular regeneration, sinusoidal dilatation, increased parenchymal draining veins, and incomplete fibrous septa) and portal tract changes (such as paraportal shunting vessel(s), portal tract remnant, increased number of portal vessels, and obliterative portal venopathy). Thirty-four archived liver samples from patients with (group A) and without (group B) INCPH were retrieved. A total of 90 representative images of lobules (L) and portal tracts (P) were distributed among 9 liver pathologists blinded to true clinical history. Each pathologist answered multiple choice questions based on the absence (Q1) or presence (Q2) of clinical history of portal hypertension. Fleiss’ kappa coefficient analysis (unweighted) was performed to assess interobserver agreement on normal versus abnormal diagnosis, in L and P, based on Q1 and Q2.

Results
The kappa values regarding normal versus abnormal diagnosis were 0.24, 0.24, 0.18 and 0.18 for L-Q1, L-Q2, P-Q1, and P-Q2, respectively. With true clinical history provided, the kappa values were L- 0.32, P-0.17 for group A and L-0.12, P-0.14 for group B. Four pathologists changed their assessments based on the provided history. Interobserver agreement on the interpretation of L and P as normal versus abnormal was slight to fair regardless of provision of clinical history.

Conclusions
Our findings indicate that the histologic features of INCPH/PSVD are not limited to patients with portal hypertension and are subject to significant interobserver variation.
Novel GANAB variants associated with polycystic liver disease
Authors: van de Laarschot Liyanne F. M. , te Morsche René H. M. , Hoischen Alexander , Venselaar Hanka , Roelofs Hennie M. , Cnossen Wybrich R. , Banales Jesus M. , Roepman Ronald , Drenth Joost P. H. 
Published: October 2020

Abstract
Background
Polycystic liver disease (PLD) is an inherited disorder characterized by numerous cysts in the liver. Autosomal dominant polycystic kidney and liver disease (ADPKD and ADPLD, respectively) have been linked to pathogenic GANAB variants. GANAB encodes the α-subunit of glucosidase II (GIIα). Here, we report the identification of novel GANAB variants in an international cohort of patients with the primary phenotype of PLD using molecular inversion probe analysis.

Results
Five novel GANAB variants were identified in a cohort of 625 patients with ADPKD or ADPLD. In silico analysis revealed that these variants are likely to affect functionally important domains of glucosidase II α-subunit. Missense variant c.1835G>C p.(Arg612Pro) was predicted to disrupt the structure of the active site of the protein, likely reducing its activity. Frameshift variant c.687delT p.(Asp229Glufs*60) introduces a premature termination codon predicted to have no activity. Two nonsense variants (c.2509C>T; p.(Arg837*), and c.2656C>T; p.(Arg886*)) and splice variant c.2002+1G>C, which causes aberrant pre-mRNA splicing and affecting RNA processing, result in truncated proteins and are predicted to cause abnormal binding of α- and β-subunits of glucosidase II, thus affecting its enzymatic activity. Analysis of glucosidase II subunits in cell lines shows expression of a truncated GIIα protein in cells with c.687delT, c.2509C>T, c.2656C>T, and c.2002+1G>C variants. Incomplete colocalization of the subunits was present in cells with c.687delT or c.2002+1G>C variants. Other variants showed normal distribution of GIIα protein.

Conclusions
We identified five novel GANAB variants associated with PLD in both ADPKD and ADPLD patients supporting a common pathway in cystogenesis. These variants may lead to decreased or complete loss of enzymatic activity of glucosidase II which makes GANAB a candidate gene to be screened in patients with an unknown genetic background.
A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend
Authors: Jacob Jobin John , Solaimalai Dhanalakshmi , Muthuirulandi Sethuvel Dhiviya Prabaa , Rachel Tanya , Jeslin Praveena , Anandan Shalini , Veeraraghavan Balaji 
Published: October 2020

Abstract
Background
The steady increase in the proportion of Non-typhoidal Salmonella (NTS) infections in humans represents a major health problem worldwide. The current study investigated the serovar distribution and antimicrobial susceptibility trends of NTS isolated from faecal samples during the period 2000–2018.

Methods
Faecal specimens of patients were cultured according to standard lab protocol. The isolates were serotyped and antimicrobial susceptibility testing (AST) were performed according to CLSI guidelines.

Results
A total of 1436 NTS isolates were obtained from faeces samples mostly comprising of S. Typhimurium (27.3%), S. Weltevreden (13%), S. Bareilly (11%), S. Newport (4.2%), S. Cholerasuis (4%), S. Infantis (3.4%), and S. Enteritidis (2.4%). Resistance to nalidixic acid (26%) was most common among the tested NTS, followed by ampicillin (18.5%), cotrimoxazole (13.5%), ciprofloxacin (12%), ceftriaxone (6.3%) and chloramphenicol (3.6%). Multidrug resistance was observed in 5% of NTS isolates with the highest rate (10.52%) in 2014. The incidence of NTS infection was maximum in children < 5 years of age with an average 19.3% of the total affected patients during the time period.

Conclusions
Based on this study, the faecal NTS isolates have high resistance rates against first line antimicrobial agents except chloramphenicol. The gradual but consistent increase in resistance to fluoroquinolones, third generation cephalosporins and macrolide may restrict future treatment options. Hence periodic monitoring of NTS infections, serotype distribution and antimicrobial resistance trend is recommended.
Clinical efficacy and molecular biomarkers in a phase II study of tucidinostat plus R-CHOP in elderly patients with newly diagnosed diffuse large B-cell lymphoma
Authors: Zhang Mu-Chen , Fang Ying , Wang Li , Cheng Shu , Fu Di , He Yang , Zhao Yan , Wang Chao-Fu , Jiang Xu-Feng , Song Qi , Xu Peng-Peng , Zhao Wei-Li 
Published: October 2020

AbstractBackgroundElderly patients with diffuse large B-cell lymphoma (DLBCL) present with poor clinical outcome and intolerance to intensive chemotherapy. Histone deacetylase inhibitors (HDACIs) show anti-lymphoma activities and can be applied to treat DLBCL. This study aimed to evaluate efficacy and safety of oral HDACI tucidinostat (formerly known as chidamide) plus R-CHOP (CR-CHOP) in elderly patients with newly diagnosed DLBCL (International Prognostic Index ≥ 2).ResultsAmong 49 patients, the complete response rate was 86%, with overall response rate achieving 94%. The 2-year progression survival (PFS) and overall survival (OS) rates were 68% (95% CI 52–79) and 83% (95% CI 68–91). Comparing with historical control (NCT01852435), the 2-year PFS and OS rates of double-expressor lymphoma phenotype (DEL) were improved, and negative prognostic effect of histone acetyltransferasesCREBBP/EP300mutations was also mitigated by CR-CHOP. Grade 3–4 neutropenia was reported in 171, grade 3–4 thrombocytopenia in 27, and grade 3 anemia in 11 of 283 cycles. No grade 4 non-hematological adverse event was reported.ConclusionCR-CHOP is effective and safe in elderly patients with newly diagnosed DLBCL. Relevance of DEL phenotype and molecular biomarkers on CR-CHOP response warrants further investigation in DLBCL.Trial registrationClinicalTrial.gov, NCT02753647. Registered on April 28, 2016.
Regenerative medicine approaches for the management of respiratory tract fistulas
Authors: Trivisonno Angelo , Nachira Dania , Boškoski Ivo , Porziella Venanzio , Di Rocco Giuliana , Baldari Silvia , Toietta Gabriele 
Published: October 2020

AbstractRespiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic and the clinical presentation is heterogeneous. Respiratory tract fistulas can lead to severely reduced health-related quality of life and short survival. Therapy mainly relies on endoscopic surgical interventions but patients often require prolonged hospitalization and may develop complications. Therefore, more conservative regenerative medicine approaches, mainly based on lipotransfer, have also been investigated. Adipose tissue can be delivered either as unprocessed tissue, or after enzymatic treatment to derive the cellular stromal vascular fraction. In the current narrative review, we provide an overview of the main tissue/cell-based clinical studies for the management of various types of respiratory tract fistulas or injuries. Clinical experience is limited, as most of the studies were performed on a small number of patients. Albeit a conclusive proof of efficacy cannot be drawn,the reviewed studies suggest that grafting of adipose tissue-derived material may represent a minimally invasive and conservative treatment option, alternative to more aggressive surgical procedures. Knowledge on safety and tolerability acquired in prior studies can lead to the design of future, larger trials that may exploit innovative procedures for tissue processing to further improve the clinical outcome.
Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing
Authors: Duan Mengna , Zhang Yan , Zhang Haiyang , Meng Yupeng , Qian Ming , Zhang Guokun 
Published: October 2020

Abstract
Background
Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve wound healing and reduce scar formation.

Methods
We investigated the therapeutic effects of EPSC-derived exosomes (EPSC-Exos) on skin wound healing in a skin-defect rat model. We also examined the roles of EPSC-Exos-specific microRNAs in inhibiting the differentiation of human dermal fibroblasts (HDF) into myofibroblasts.

Results
We found that EPSC-Exos increased the wound healing rate and reduced scar formation in rats. Also, EPSC-Exos improved the regeneration levels of skin appendages, nerves and vessels, as well as the natural distribution of collagen. Furthermore, we found these functions may be achieved by inhibiting the activity of transforming growth factor-β1 (TGF-β1) and its downstream genes. The results showed that some specific microRNAs, including miR-16, let-7a, miR-425-5p and miR-142-3p, were enriched in EPSC-Exos. EPSC-Exos-specific microRNAs, especially miR-425-5p and miR-142-3p, played vital roles in inhibiting myofibroblast differentiation via reducing the TGF-β1 expression in dermal fibroblasts.

Conclusion
We found a novel function of EPSC-Exos-specific microRNAs, suggesting that EPSC-Exos might represent a strategy to prevent scar formation during wound healing in the clinical setting.
Threshold dynamics and threshold analysis of HIV infection model with treatment
Authors: Chen Zhimin , Liu Xiuxiang , Zeng Liling 
Published: October 2020

AbstractIn this paper, a human immunodeficiency virus (HIV) infection model that includes a protease inhibitor (PI), two intracellular delays, and a general incidence function is derived from biologically natural assumptions. The global dynamical behavior of the model in terms of the basic reproduction number$\mathcal{R}_{0}$R0is investigated by the methods of Lyapunov functional and limiting system. The infection-free equilibrium is globally asymptotically stable if$\mathcal{R}_{0}\leq 1$R0≤1. If$\mathcal{R}_{0}>1$R0>1, then the positive equilibrium is globally asymptotically stable. Finally, numerical simulations are performed to illustrate the main results and to analyze thre effects of time delays and the efficacy of the PI on$\mathcal{R}_{0}$R0.
RETRACTED ARTICLE: Hermite–Hadamard-type inequalities for $\eta _{h}$-convex functions via ψ-Riemann–Liouville fractional integrals
Authors: Park Choonkil , Chu Yu-Ming , Saleem Muhammad Shoaib , Mukhtar Sana , Rehman Nasir 
Published: October 2020

AbstractIn this paper, we establish some new Hermite–Hadamard type inequalities involving ψ-Riemann–Liouville fractional integrals via $\eta _{h}$

η
h

-convex functions. Finally, we give some applications to the special means of real numbers.
An efficient and secure data sharing scheme for mobile devices in cloud computing
Authors: Lu Xiuqing , Pan Zhenkuan , Xian Hequn 
Published: October 2020

AbstractWith the development of big data and cloud computing, more and more enterprises prefer to store their data in cloud and share the data among their authorized employees efficiently and securely. So far, many different data sharing schemes in different fields have been proposed. However, sharing sensitive data in cloud still faces some challenges such as achieving data privacy and lightweight operations at resource constrained mobile terminals. Furthermore, most data sharing schemes have no integrity verification mechanism, which would result in wrong computation results for users. To solve the problems, we propose an efficient and secure data sharing scheme for mobile devices in cloud computing. Firstly, the scheme guarantees security and authorized access of shared sensitive data. Secondly, the scheme realizes efficient integrity verification before users share the data to avoid incorrect computation. Finally, the scheme achieves lightweight operations of mobile terminals on both data owner and data requester sides.
Uptake of Nutri-Score during the first year of implementation in Belgium
Authors: Vandevijvere Stefanie 
Published: October 2020

Abstract
Background
Front-of-pack (FOP) nutrition labeling has been recommended by the World Health Organization (WHO) as one of a suite of measures needed to improve population diets. The voluntary Nutri-Score FOP labeling system, which was first implemented in France, was approved for implementation in Belgium by the Minister of Public Health in August 2018 and has been officially adopted in Belgium since April 1st 2019. We assessed the uptake of Nutri-Score by food retailers and manufacturers during the first year of implementation in Belgium.

Main body
In November–December 2019, pictures for 1781 products displaying Nutri-Score on the FOP were collected from the five biggest retailers, representing about 10% of products on the market in Belgium. About 90% of products displaying Nutri-Score on the FOP in 2019 were own-brand products from two major food retailers, while the few remainder were branded products. About 56% of products displayed Nutri-Score A or B while 26% of products displayed Nutri-Score D or E.

Conclusion
During the first year of implementation, > 1700 food products displayed Nutri-Score on the FOP in Belgium. While the majority of those products were healthier foods (Nutri-Score A&B), about one quarter of less healthy products (Nutri-Score D&E) already displayed Nutri-Score as well. In the meantime, all five biggest retailers, including discounters, have committed to display Nutri-Score on the FOP from 2020 onwards, which may increase pressure on other food manufacturers to improve uptake of Nutri-Score for branded products.
A qualitative study of microaggressions against African Americans on predominantly White campuses
Authors: Williams Monnica T. , Skinta Matthew D. , Kanter Jonathan W. , Martin-Willett Renée , Mier-Chairez Judy , Debreaux Marlena , Rosen Daniel C. 
Published: October 2020

Abstract
Background
Pierce’s (The Black seventies: an extending horizon book, 1970) conception of “subtle and stunning” daily racial offenses, or microaggressions, remains salient even 50 years after it was introduced. Microaggressions were defined further by Sue and colleagues (Am Psychol 62:271, 2007), and this construct has found growing utility as the deleterious effects of microaggressions on the health of people of color continues to mount. Microaggressions are common on campuses and contribute to negative social, academic, and mental health outcomes.

Method
This paper explores how Black college students’ experiences correspond to or differ from the microaggression types originally proposed by Sue et al. (Am Psychol 62:271, 2007). Themes were identified from focus group data of students of color (N = 36) from predominately White institutions (PWIs) of higher learning (N = 3) using interpretative phenomenological analysis.

Results
We identified 15 categories of racial microaggressions, largely consistent with the original taxonomy of Sue et al. but expanded in several notable ways. New categories in our data and observed by other researchers, included categories termed Connecting via Stereotypes, Exoticization and Eroticization, and Avoidance and Distancing. Lesser studied categories identified included Sue et al.’s Denial of Individual Racism, and new categories termed Reverse Racism Hostility, Connecting via Stereotypes, and Environmental Attacks.

Discussion
While previous literature has either embraced the taxonomy developed by Sue and colleagues or proposed a novel taxonomy, this study synthesized the Sue framework in concert with our own focus group findings and the contributions of other researchers. Improving our understanding of microaggressions as they impact people of color may better allow for improved understanding and measurement of this important construct.
A systematic literature review of personalized learning terms
Authors: Shemshack Atikah , Spector Jonathan Michael 
Published: October 2020

AbstractLearning is a natural human activity that is shaped by personal experiences, cognitive awareness, personal bias, opinions, cultural background, and environment. Learning has been defined as a stable and persistent change in what a person knows and can do. Learning is formed through an individual’s interactions, including the conveyance of knowledge and skills from others and experiences. So, learning is a personalized experience that allows one to expand their knowledge, perspective, skills, and understanding. Therefore, personalized learning models can help to meet individual needs and goals. Furthermore, to personalize the learning experience, technology integration can play a crucial role. This paper provides a review of the recent research literature on personalized learning as technology is changing how learning can be effectively personalized. The emphasis is on the terms used to characterize learning as those can suggest a framework for personalized and will eventually be used in meta-analyses of research on personalized learning, which is beyond the scope of this paper.
The allocation between egg size and clutch size depends on local nest survival rate in a mean of bet-hedging in a shorebird
Authors: Song Zitan , Lin Xin , Que Pinjia , Halimubieke Naerhulan , Huang Qin , Zhang Zhengwang , Székely Tamás , Liu Yang 
Published: October 2020

AbstractBackgroundThe allocation of resources between offspring size and number is a central question of life-history theory. Although several studies have tested the existence of this trade-off, few studies have investigated how environmental variation influences the allocation of resources to offspring size and offspring number. Additionally, the relationship between population dynamics and the offspring size and number allocation is far less understood.MethodsWe investigate whether resource allocation between egg size and clutch size is influenced by the ambient temperature and whether it may be related to apparent nest survival rate. We measured 1548 eggs from 541 nests of two closely related shorebird species, the Kentish Plover (Charadrius alexandrinus) and the White-faced Plover (C. dealbatus) in China, in four populations that exhibit contrasting ambient environments. We weighed females, monitored nest survival, and calculated the variance of ambient temperature.ResultsAlthough we found that egg size and clutch size were all different between the four breeding populations, the reproductive investment (i.e. total clutch volume) was similar between populations. We also found that populations with a high survival rate had relatively larger eggs and a smaller clutch than populations with a low nest survival rate. The latter result is in line with a conservative/diversified bet-hedging strategy.ConclusionsOur findings suggest that plovers may increasing fitness by investing fewer, larger or many, small according local nest survival rate to make a similar investment in reproduction, and thereby may have an impact on population demography.
Improving precision of field inventory estimation of aboveground biomass through an alternative view on plot biomass
Authors: Kleinn Christoph , Magnussen Steen , Nölke Nils , Magdon Paul , Álvarez-González Juan Gabriel , Fehrmann Lutz , Pérez-Cruzado César 
Published: October 2020

AbstractWe contrast a new continuous approach (CA) for estimating plot-level above-ground biomass (AGB) in forest inventories with the current approach of estimating AGB exclusively from the tree-level AGB predicted for each tree in a plot, henceforth called DA (discrete approach). With the CA, the AGB in a forest is modelled as a continuous surface and the AGB estimate for a fixed-area plot is computed as the integral of the AGB surface taken over the plot area. Hence with the CA, the portion of the biomass of in-plot trees that extends across the plot perimeter is ignored while the biomass from trees outside of the plot reaching inside the plot is added. We use a sampling simulation with data from a fully mapped two hectare area to illustrate that important differences in plot-level AGB estimates can emerge. Ideally CA-based estimates of mean AGB should be less variable than those derived from the DA. If realized, this difference translates to a higher precision from field sampling, or a lower required sample size. In our case study with a target precision of 5% (i.e. relative standard error of the estimated mean AGB), the CA required a 27.1% lower sample size for small plots of 100 m2 and a 10.4% lower sample size for larger plots of 1700 m2. We examined sampling induced errors only and did not yet consider model errors. We discuss practical issues in implementing the CA in field inventories and the potential in applications that model biomass with remote sensing data. The CA is a variation on a plot design for above-ground forest biomass; as such it can be applied in combination with any forest inventory sampling design.