bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization of antennal lobe glomeruli activated by nonappetitive D-limonene and appetitive 1-octen-3-ol odors via two types of olfactory organs in the blowfly Phormia regina
Authors: Maeda Toru , Nisimura Tomoyosi , Habe Shunnya , Uebi Tatsuya , Ozaki Mamiko 
Published: November 2020

AbstractAppetite or feeding motivation relies significantly on food odors. In the blowflyPhormia regina, feeding motivation for sucrose is decreased by the odor ofd-limonene but increased by the odor of 1-octen-3-ol odor. These flies have antennal lobes (ALs) consisting of several tens of glomerular pairs as a primary olfactory center in the brain. Odor information from different olfactory organs—specifically, the antennae and maxillary palps—goes to the corresponding glomeruli. To investigate how odors differently affect feeding motivation, we identified the olfactory organs and glomeruli that are activated by nonappetitive and appetitive odors. We first constructed a glomerular map of the antennal lobe inP. regina. Anterograde fluorescence labeling of antennal and maxillary afferent nerves, both of which project into the contralateral and ipsilateral ALs, revealed differential staining in glomerular regions. Some of the axonal fiber bundles from the antennae and maxillary palps projected to the subesophageal ganglion (SOG). We visualized the activation of the glomeruli in response to odor stimuli by immunostaining phosphorylated extracellular signal-regulated kinase (pERK). We observed different glomerulus activation under different odor stimulations. Referring to our glomerular map, we determined that antennal exposure tod-limonene odor activated the DA13 glomeruli, while exposure of the maxillary palps to 1-octen-3-ol activated the MxB1 glomeruli. Our results indicated that a nonappetitive odor input from the antennae and an appetitive odor input from the maxillary palps activate different glomeruli in the different regions of ALs in the blowflyP. regina. Collectively, our findings suggest that compartmentalization of glomeruli in AL is essential for proper transmission of odor information.
Perspectives on the COVID-19 pandemic impact on cardio-oncology: results from the COVID-19 International Collaborative Network survey
Authors:   on behalf of the Cardio-Oncology International Collaborative Network, Sadler Diego , DeCara Jeanne M. , Herrmann Joerg , Arnold Anita , Ghosh Arjun K. , Abdel-Qadir Husam , Yang Eric H. , Szmit Sebastian , Akhter Nausheen , Leja Monika , Silva Carolina Maria Pinto Domingues Carv , Raikhelkar Jayant , Brown Sherry-Ann , Dent Susan , O’Quinn Rupal , Thuny Franck , Moudgil Rohit , Raez Luis E. , Okwuosa Tochukwu , Daniele Andres , Bauer Brenton , Kondapalli Lavanya , Ismail-Khan Roohi , Lax Jorge , Blaes Anne , Nahleh Zeina , Elson Leah , Baldassarre Lauren A. , Zaha Vlad , Rao Vijay , Lara Daniel Sierra , Skurka Kerry 
Published: November 2020

AbstractBackgroundRe-allocation of resources during the COVID-19 pandemic has resulted in delays in care delivery to patients with cardiovascular disease and cancer. The ability of health care providers to provide optimal care in this setting has not been formally evaluated.ObjectivesTo assess the impact of COVID-19 resource re-allocation on scheduling, testing, elective procedures, telemedicine access, use of new COVID-19 therapies, and providers’ opinions on healthcare policies among oncology and cardiology practitioners.MethodsAn electronic survey was conducted by a cardio-oncology collaborative network through regional and state chapters of the American College of Cardiology, American Society of Clinical Oncology, and the International Cardio-Oncology Society. Descriptive statistics were reported by frequency and proportion for analyses, and stratified categorically by geographic region and specialty.ResultsOne thousand four hundred fifteen providers (43 countries) participated: 986 cardiologists, 306 oncologists, and 118 trainees/internal medicine. 63% (195/306) of oncologists vs 92% (896/976) of cardiologists reported cancellations of treatments/elective procedures (p = 0.01). 46% (442/970) of cardiologists and 25% (76/303) of oncologists modified the scope of their practice (p = < 0.001). Academic physicians (74.5%) felt better supplied with personal protective equipment (PPE) vs non-academic (74.5% vs 67.2%;p = 0.018). Telemedicine was less common in Europe 81% (74/91), and Latin America 64% (101/158), than the United States, 88% (950/1097) (p = < 0.001). 95% of all groups supported more active leadership from medical professional societies.ConclusionsThese results support initiatives to promote expanded coverage for telemedicine, increased access to PPE, better testing availability and involvement of medical professional societies to help with preparedness for future health care crisis.
A fast boundary protection for an AC transmission line connected to an LCC-HVDC inverter station
Authors: Liu Zhen , Gao Houlei , Luo Sibei , Zhao Le , Feng Yuyao 
Published: November 2020

AbstractFor AC transmission lines connected to an LCC-HVDC inverter station, commutation failure can lead to the wrong operation of traditional protection. To solve the problem, this paper proposes a fast protection scheme using transient information from one end of the AC line. The boundary frequency characteristics of the AC line connected to LCC-HVDC inverter are analyzed first. This reveals the existence of significant attenuation on both high frequency signals and some specific frequency signals. Based on the boundary characteristics, a novel boundary protection principle utilizing a backward traveling wave is then proposed. A PSCAD/EMTDC simulation model of a ± 800 kV LCC-HVDC and 500 kV AC transmission system is established, and different fault cases are simulated. The simulation results prove that the novel protection principle is immune to commutation failure, fault resistance and fault type.
Effect of endophytic isolates of Beauveria bassiana (Balsamo) Vuillemin and Metarhizium anisopliae (Metchnikoff) Sorokin on Plutella xylostella (L.) (Lepidoptera: Plutellidae) in cabbage
Authors: Bathina Poornesha , Bonam Ramanujam 
Published: November 2020

Abstract
Background
The diamondback moth (Plutella xylostella L.) (Lepidoptera: Plutellidae) is one of the major pests in cabbage which causes severe loss to the cruciferous crops. Entomopathogenic fungi Beauveria bassiana and Metarhizium anisopliae have been established as endophytes in cabbage plants by seed treatment/root inoculation/foliar application methods in glasshouse conditions.

Main body
A glasshouse experiment was conducted to study the effect of endophytic isolates of B. bassiana (NBAIR Bb-5a and NBAIR Bb-45) and M. anisopliae (NBAIR Ma-4 and NBAIR Ma-35) on P. xylostella in cabbage using detached leaf bioassay method. The isolates were applied through seed treatment/root inoculation/foliar application at the concentration of 1 × 108 spores/ml and evaluated at 15, 30, 45, and 60 days after treatment (DAT) in 2017 and 2018. These isolates were colonized in cabbage leaf tissues from 15 to 60 DAT. All 4 isolates showed different mortality percentages during 15–30 DAT, and no mortality was observed after 45 and 60 DAT in different inoculation methods during both years. Among the application methods tested, foliar application method gave the highest mortality of 70–80% at 15 DAT and 12–58% at 30 DAT mortality of 2nd instar larvae of P. xylostella in cabbage. Among the isolates tested, NBAIR Ma-35 showed the highest mortality (35–79%) in all the 3 inoculation methods tested.

Conclusion
Endophytic isolates of B. bassiana and M. anisopliae suppressed the population of P. xylostella on cabbage leaves in three inoculation methods tested. Among all the methods tested, foliar application method showed highest mortality. These promising isolates have to be further tested under field conditions for management of P. xylostella in cabbage.
Successful airway management of twin coincidental supraglottic and thyroid masses with difficult fiber optic intubation: a case report
Authors: Bawa Chashamjot , Ramdev Babita , Sarna Rashi , Reddum Praveena Venkatreddy 
Published: November 2020

Abstract
Background
Aberrant airway anatomy in cases of laryngeal carcinomas makes airway management a herculean task for the anesthesiologist. What can further compound the situation is an external compression by thyroid mass.

Case presentation
We present a case report of successful airway management by awake nasal fiberoptic intubation in a 65-year-old male who was found to have compressive symptoms due to thyroid swelling in addition to supraglottic obstructive mass. Although a detailed airway examination and indirect laryngoscope did assist in planning the procedure, but what lay inside could only be dealt with by having an in-depth orientation of airway anatomy, practical know-how to fiberoptic scope, and swift reflexes to prevent an adverse event.

Conclusion
From our experience, fiberoptic intubation can only be optimally utilized if emphasis is laid on planning and preparation for the procedure which are key elements in making any difficult airway management successful.
Pivotal role of PET/CT in characterization of occult metastasis with undetermined origin
Authors: Zytoon Ashraf Anas , Elsayed Elsayed Elmekkawy , Nassar Amr Ibrahim , Murakami Koji 
Published: November 2020

Abstract
Background
The purpose of this multicenter diagnostic accuracy test study was conducted to assess the role of positron emission tomography/computed tomography in the detection of primary tumor in cases of metastasis of undetermined primary site, to estimate its capability in detecting additional lesions as well as evaluating disease burden and staging. This multicentric diagnostic accuracy test study included 175 patients with pathologically proven, radiologically, and/or clinically suspected metastatic lesions of undetermined primary site. Clinical, surgical, and histopathologic findings and correlative imaging modalities were used to assess the results of PET/CT; the accuracy of PET/CT was expressed in terms of sensitivity and specificity, positive and negative predictive values.

Results
The study included 175 patients; PET-CT-positive lesions suggestive of primary malignant tumors were detected in 105 out of 175 patients. These lesions were pathologically proven to be malignant (true positive) in 100/175 patients (57.1%). Five out of 175 patients (2.9%) proved to be falsely positive after pathologic assessment; 70 out of 175 patients (40%) were negative for detection of primary malignancy all over the body by PET/CT (true negative) with no false negative results. PET/CT achieved a sensitivity of 100%, and specificity of 93.3% in detection of unknown primary tumor location.

Conclusion
PET/CT is an effective modality for early detection of the primary tumor site in patients with cancer of undetermined primary (CUP) which facilitates early selection of appropriate treatment protocols that will improve patients’ prognosis.
Antioxidant and antidiabetic properties of isolated fractions from methanolic extract derived from the whole plant of Cleome viscosa L.
Authors: Suresh Yarrappagaari , Rajasekar Gutha , Lavanya Thopireddy , Lakshminarsimhulu Benne , Reddy Kesireddy Sathyavelu , Reddy Saddala Rajeswara 
Published: November 2020

AbstractBackgroundCleome viscosais considered as an important medicinal plant extensively used in India, China, Bangladesh, and a few countries in Africa. In the present study, in vitro anti-radical and antidiabetic potential of isolated fractions of methanolic extract ofC.viscosawhole plant (MeCV) has been investigated. The identification of polyphenols and their related functional groups in the bioactive fraction was categorized by using HPLC and FT-IR.ResultsThe total phenolic and flavonoid contents of F-D were higher than those of F-A, F-B, and F-C. The F-D exhibited superior antioxidant capacity when compared with the remaining three fractions. However, the F-D showed the highest glucose diffusion activity over the 30 min–27 h incubation period and also inhibited both α-glucosidase and α-amylase enzyme activity. HPLC analysis revealed the presence of the two known compounds (protocatechuic acid hexoside, rutin) and six unknown compounds in the F-D. FTIR spectrum confirmed the presence of phenol group.ConclusionThe isolated F-D obtained from MeCV displayed superior antioxidant and antidiabetic activity which indicate the presence of polyphenols in the fraction. The data findings of the present study support the traditional uses of the whole plant ofC.viscosaas a promising natural source of biological medicines for oxidative stress and diabetes.
11C-Metomidate PET/CT Detected Multiple Ectopic Adrenal Rest Tumors in a Woman With Congenital Adrenal Hyperplasia
Authors: Burman Pia , Falhammar Henrik , Waldenström Erik , Sundin Anders , Bitzén Ulrika 
Published: November 2020

Abstract

Context
Women with congenital adrenal hyperplasia (CAH) may present with androgen excess that is difficult to control with conventional suppressive doses of glucocorticoids. Clinical management is challenging, and the woman is at great risk of developing steroid-induced complications.

Patients and Methods
A 32-year-old woman with salt-wasting CAH due to 21-hydroxylase deficiency underwent right-sided adrenalectomy because of a large myelolipoma. Over the years, androgens became increasingly difficult to suppress on prednisolone 5 + 0 + 2.5 mg daily, and at age 39 years the left adrenal with an enlarging myelolipoma was removed. A month later serum testosterone levels had increased from 4.1 preoperatively to 18.3 nmol/L (reference 0.2-1.8 nmol/L), and adrenocorticotropin levels from 32 to 283 pmol/L (reference &lt; 14 pmol/L). No adrenal parenchyma was visualized on computed tomography (CT). In the further search for the source of the markedly elevated testosterone, positron emission tomography (PET) was performed with 2 different tracers, 18fluorodeoxyglucose (18FDG) reflecting glucose metabolism and 11C-metomidate, an inhibitor of 11-β-hydroxylase targeting adrenocortical tissue.

Results
18FDG-PET/CT with cosyntropin stimulation showed ovarian/paraovarian hypermetabolism, suggestive of adrenal rest tumors. Further characterization with 11C-metomidate PET/CT showed uptakes localized to the ovaries/adnexa, behind the spleen, and between the right crus diaphragmaticus and inferior vena cava.

Conclusion
Adrenal rest tumors can give rise to high androgen levels in spite of suppressive supraphysiological glucocorticoid doses. This case illustrates, for the first time, the value of 11C-metomidate PET as a sensitive method in documenting adrenal rest tumors, currently considered rare in women with CAH.
Calcium Stimulation Test for Insulinoma Localization in an End-stage Renal Disease Patient on Diazoxide
Authors: Kim Stephanie , Conrad Miles , Chuang Eunice , Cai Larry , Masharani Umesh , Murphy Elizabeth J 
Published: November 2020

Abstract
Insulinomas are rare, and even rarer in patients with end-stage renal disease (ESRD). Clear criteria for the biochemical diagnosis of insulinomas in patients with renal failure have not been established, and hypoglycemia is often attributed to the renal disease itself, frequently leading to a delay in diagnosis. We describe a case of a patient who presented with asymptomatic recurrent hypoglycemia during hemodialysis. Disease progression and biochemical testing strongly suggested an insulinoma. Computed tomography (CT) of the abdomen and pelvis, 111In-pentetreotide scintigraphy and endoscopic ultrasound did not localize a pancreatic tumor. A calcium stimulation test was performed while the patient was taking diazoxide due to severe hypoglycemia with fasting for a couple of hours without treatment. The test showed a marked increase in insulin after calcium infusion in the dorsal pancreatic artery, localizing the tumor to the body and tail of the gland. Exploratory surgery easily identified a tumor at the body of the pancreas and pathology confirmed an insulin-secreting pancreatic neuroendocrine tumor. On follow-up, there was resolution of the hypoglycemia. We review the challenges of diagnosing an insulinoma in ESRD and describe a successful intra-arterial calcium stimulation test done in an ESRD patient while continuing diazoxide.
МОДЕЛИРОВАНИЕ ТРЕНАЖЕРНОЙ ОБРАЗОВАТЕЛЬНОЙ ИНФОРМАЦИОННОЙ СРЕДЫ ДЛЯ ОБУЧЕНИЯ ВОДИТЕЛЕЙ АВТОТРАНСПОРТНЫХ СРЕДСТВ
Authors: Davidovsky Anatoly Grigorevich , Linnik Aleksey Mikhaylovich 
Published: November 2020

В статье рассмотрены основы математического моделирования и функциональной организации тренажерной образовательной информационной среды для обучения водителей автотранспортных средств и инженерно-технических специалистов по эксплуатации наземного беспилотного транспорта.Цель: разработка и обоснование математической модели и функциональной организации тренажерной образовательной информационной среды для обучения водителей автотранспортных средств и инженерно-технических специалистов по эксплуатации наземного беспилотного транспорта.Методология работы включает подходы кортежного и формального моделирования.Результаты: разработана математическая модель и функциональная структура тренажерной образовательной информационной среды для обучения водителей автотранспортных средств, а в перспективе – пользователей и инженерно-технических специалистов по эксплуатации наземного беспилотного транспорта.Область применения результатов: полученные результаты могут быть использованы в области разработки, развития и применения тренажерных обучающих систем для подготовки водителей различных категорий и специалистов в сфере автомобильного транспорта.
Green IT Quick Wins
Authors: Gonserkewitz Phil , Schmermbeck Helge , Ahlemann Frederik 
Published: November 2020

ZusammenfassungUnternehmen müssen immer höheren Umweltanforderungen gerecht werden. Ein vermehrter Einsatz von Informationstechnologien (IT) und Informationssystemen (IS), sowie deren Einbeziehung in Nachhaltigkeitsinitiativen können dabei einen großen Beitrag leisten. Um Manager dabei zu unterstützen, haben wir Literatur analysiert und Green IT und Green IS Maßnahmen identifiziert und nach Umsetzbarkeit und ökologischen Benefits kategorisiert. Wir stellen insbesondere schnell umsetzbare Maßnahmen mit hohen ökologischen Benefits vor (Quick Wins), von denen viele einen direkten Bezug zu Nutzung und Management von Hardware haben und daher als Green IT-Maßnahmen kategorisiert werden können. Es wird deutlich, dass diese Maßnahmen als erste Schritte hin zu einer langfristigen Nachhaltigkeitsstrategie, welche die organisationsinterne sowie -übergreifende Nutzung von IT und IS beinhaltet, abzielt. Aufgrund der Diversität von Unternehmen stellen die Ergebnisse jedoch keine Universallösung dar, sondern müssen den Charakteristika des jeweiligen Unternehmens entsprechend bewertet und angepasst werden.
Territorialización y desterritorialización del modelo de agronegocios en América del Sur
Authors: Deon Joaquín Ulises 
Published: November 2020

El desastre humanitario y ambiental de las últimas tres décadas (1990, 2000 y 2010) provocado por el modelo agroindustrial ha implicado dos grandes alternativas socioproductivas que consolidaron dos modelos políticos y económicos que se enfrentan territorial y públicamente: el Modelo de Agronegocios, que ya lleva millones de hectáreas ganadas con iguales estrategias del modelo agroindustrial; y, no alineado a este (Gras y Hernandez 2013:3) y emergente como modelo alternativo-societal, el Modelo Agroecológico y de autonomía/soberanía alimentaria (Such, 2012), con toda su dinámica de movimientos sociales, asociada en Sudamérica. Este último modelo en construcción ha ganado sendas batallas desterritorializando al Agronegocio, pero este último ha modificado su accionar para reterritorializarse de la mano de la (re)neoliberalización del Conosur. Se propone aquí describir y analizar los conflictos entre estos modelos a partir de metodologías de investigación, acción, fuentes informativas y balances empresariales, notas periodísticas, ordenanzas y leyes, entre otras, buscando responder a la pregunta ¿Cómo se territorializan y tensionan estos modelos en Sudamérica y particularmente en Córdoba, Argentina?
Bibliotekundervisningens fremtid – nytt fokus på metodikk og digitalisering
Authors: Grote Michael , Faber Hege Charlotte 
Published: November 2020

I løpet av de siste årene har både fakulteter og universitetsbibliotek i Norge begynt å tilby tverrfaglige kurs for ph.d.-kandidater, og nye nettbaserte ressurser gir informasjon om diverse arbeidsverktøy og metodikk som er relevant i forskerutdanningen. Parallelt med dette har den tradisjonelle bibliotekundervisningen forandret seg: Gjennom å åpne bibliotekkurs for nye emner som akademisk skriving, akademisk redelighet og datahåndtering, blir begrepet «informasjonskompetanse» utvidet og nye undervisningsformer utprøvd. I tillegg er målgruppen for ph.d.-kurs på bibliotekene svært heterogen: Det finnes store forskjeller angående metoder og arbeidsmåter mellom fakulteter, fag, fagdisipliner og prosjekter, og prosjektenes faglige spesialisering og tverrfaglighet øker behovet for skreddersydde svar.
Både de nye læringsområdene og behovet for individuell veiledning utfordrer tradisjonelle konsepter for bibliotekundervisning, som gjerne har vært generaliserende og instruksjonsbasert. Utfordringen med målgruppens faglige heterogenitet besvares med ph.d.-kurs i «overførbare ferdigheter» («transferable» eller «generic skills») og forsøk på å finne fagovergripende standarder for nøkkelkompetanser som søk, litteraturkartlegging eller skriving av akademiske tekster. De nye temaene i bibliotekenes ph.d.-undervisning som skriveprosess, arbeidsflyt og etiske problemstillinger kan ikke ivaretas gjennom instruksjonsbaserte læringsformer. Men også kurstilbudene i overførbare ferdigheter møter utfordringer: Overføring av kunnskap og konkretisering av generaliserte arbeidsteknikker krever rom for praktisk arbeid med individuelle prosjekter i bibliotekundervisningen. Foredraget viste forskjellige eksempler for studentaktive læringsformer gjennom digitalt støttet undervisningsmetodikk. Ved hjelp av nettressursen www.phdontrack.net kan ph.d.-kandidatene selvstendig tilegne seg generalisert informasjon, mens ph.d.-undervisningen kan fokusere på praktisk arbeid med de individuelle forskningsprosjektene.
Caminhos metodológicos de pesquisa participativa que analisa vivências na pandemia de Covid-19 em populações vulneráveis
Authors: Almeida Castro Furtado Lumena , Fegadolli Claudia , Chioro Arthur , Kazuo Nakano Anderson , Gonçalves da Silva Cristiane , De Paula Liana , Rosa de Souza Luciana , Arantes Nasser Mariana 
Published: November 2020

O objetivo geral do artigo é compartilhar a investigação em curso que se propõe a analisar as vivências, os processos e os impactos sistêmicos da pandemia de COVID-19 e das medidas e ações realizadas para a sua prevenção, contenção e enfrentamento. O estudo considera as desigualdades nas vivências da pandemia em populações de diferentes territórios vulneráveis. São 14 territórios da Região Metropolitana de São Paulo e da Baixada Santista. O delineamento da pesquisa busca qualificar o olhar para a vivência da pandemia em sua complexidade, via uma produção interdisciplinar do conhecimento, realizada junto com as populações estudadas. O coletivo de pesquisadores é formado por moradores dos territórios, estudantes e pesquisadores ligados à universidade. Unifica este coletivo o compromisso de produzir conhecimentos científicos socialmente referenciados. O desenvolvimento da pesquisa, em cada território, produzida em conjunto com pesquisadores sociais e organizações coletivas, tem permitido uma reflexão crítica e visibilizado à centralidade das redes construídas pelos atores locais. Esse percurso permite considerar o modo de produzir vida em territórios marcados pela desigualdade e reconhecer seus desafios. Caminhar nesse complexo processo atravessado pela pandemia é o desafio e a riqueza desse estudo.