bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood Urinary Tract Infections and Pregnancy-Related Complications in Adult Women
Authors: Honkila Minna , Hannula Annukka , Pokka Tytti , Hanni Anna-Maija , Salo Jarmo , Renko Marjo , Vääräsmäki Marja , Perhomaa Marja , Keskimäinen Elina , Uhari Matti , Tapiainen Terhi 
Published: July 2020

BACKGROUND AND OBJECTIVES:
Long-term outcomes of urinary tract infection (UTI) in childhood are not well known. Pregnancy may reveal latent renal damage caused by a UTI because of stress on the kidneys.

METHODS:
Our cohort included adult women with an ultrasonography taken because of a childhood UTI in 1981–1991 (N = 1175). Nine women with a severe congenital kidney malformation or urinary tract obstruction were excluded. Altogether, 260 mothers with a childhood UTI and 500 population-based control mothers without a childhood UTI matched for age, and delivery dates were compared. Our primary end point was the proportion of women with essential or gestational hypertension, preeclampsia, proteinuria, or pyelonephritis during the first pregnancy.

RESULTS:
The pregnancy outcomes of the women with a UTI in childhood did not differ from those of the controls because 105 of 260 (40%) patients met the primary end point compared with 204 of 500 (41%) controls (relative risk [RR] 0.99; 95% confidence interval [CI] 0.82 to 1.2; P = .91). Similarly, there were no significant differences between the 2 groups in essential hypertension (RR 1.0; 95% CI 0.65 to 1.6; P = .92), gestational hypertension (RR 0.93; 95% CI 0.74 to 1.2; P = .54), preeclampsia (RR 1.5; 95% CI 0.91 to 2.5; P = .11), proteinuria (RR 1.2; 95% CI 0.81 to 1.8; P = .36) or pyelonephritis (2 controls and none of the patients; P = .55) during the first pregnancy.

CONCLUSIONS:
Childhood UTIs did not increase the risk of pregnancy-related complications in this controlled population-based study. Thus, UTIs in childhood without severe urinary tract abnormalities appear to have a minimal effect on kidney health in early adulthood.
Traditional Medicine and Magic According to Some Ethiopian Manuscripts from European Collections
Authors: Burtea Bogdan 
Published: July 2020

The present paper is dealing exclusively with medico-magical texts and traditions from a Christian Ethiopian environment. The handbooks and collections of various traditional healers in Ethiopia have played a significant role in the chain of transmission of medical and magical knowledge. This paper will focus on the structure and composition strategy exemplified by four Ethiopian manuscripts (MS Or. 11390 from the British Library, MS Éthiopien 402, 402 and 648 from the Bibliothèque nationale Paris). The analysis shows how the specialist knowledge was transmitted, preserved and reused. Moreover, it sheds some light on the protagonists of this transfer.
Phase Ib/II Study of Biweekly TAS-102 in Combination with Bevacizumab for Patients with Metastatic Colorectal Cancer Refractory to Standard Therapies (BiTS Study)
Authors: Satake Hironaga , Kato Takeshi , Oba Koji , Kotaka Masahito , Kagawa Yoshinori , Yasui Hisateru , Nakamura Masato , Watanabe Takanori , Matsumoto Toshihiko , Kii Takayuki , Terazawa Tetsuji , Makiyama Akitaka , Takano Nao , Yokota Mitsuru , Okita Yoshihiro , Matoba Koreatsu , Hasegawa Hiroko , Tsuji Akihito , Komatsu Yoshito , Yoshino Takayuki , Yamazaki Kentaro , Mishima Hideyuki , Oki Eiji , Nagata Naoki , Sakamoto Junichi 
Published: July 2020

Abstract

Lessons Learned
A biweekly TAS-102 plus BEV schedule in patients with heavily pretreated mCRC showed equivalent efficacy with less toxicity compared with the current schedule of TAS-102 plus BEV combination. Biweekly TAS-102 plus BEV combination could reduce unnecessary dose reduction of TAS-102, maintain higher doses, and possibly be effective even in cases without chemotherapy-induced neutropenia (CIN). The prespecified subgroup analysis of this study showed an obvious association between CIN within the first two cycles and prognosis of biweekly TAS-102 plus BEV.

Background
TAS-102 (trifluridine/tipiracil) plus bevacizumab (BEV) combination therapy has shown promising activity in patients with metastatic colorectal cancer (mCRC). However, the previously reported dose and schedule for the TAS-102 (70 mg/m2/day on days 1–5 and 8–12, every 4 weeks) plus BEV (5 mg/kg on day 1, every 2 weeks) regimen is complicated by severe hematological toxicities and difficult administration schedules. Here, we evaluated the efficacy and safety of a more convenient biweekly TAS-102 plus BEV combination.

Methods
Patients with mCRC who were refractory or intolerant to standard chemotherapies were enrolled. Patients received biweekly TAS-102 (twice daily on days 1–5, every 2 weeks) with BEV (5mg/kg on day 1, every 2 weeks). The primary endpoint was progression-free survival rate at 16 weeks (16-w PFS rate).

Results
From October 2017 to January 2018, 46 patients were enrolled. The recommended phase II dose was determined to be TAS-102 (70 mg/m2/day). Of the 44 eligible patients, the 16-w PFS rate was 40.9% (95% confidence interval, 26.3%–56.8%), and the null hypothesis was rejected (p &lt; .0001). Median progression-free survival (PFS) and overall survival were 4.29 months and 10.86 months, respectively. Disease control rate was 59.1%. Common grade 3 or higher adverse events were hypertension (40.9%), neutropenia (15.9%), and leucopenia (15.9%).

Conclusion
Biweekly TAS-102 plus BEV showed promising antitumor activity with safety.
ADVANTAGES AND DISADVANTAGES OF USING MACHINE TRANSLATION IN TRANSLATION PEDAGOGY FROM THE PERSPECTIVE OF INSTRUCTORS AND LEARNERS
Authors: Akbari Motlaq Mohamad Djavad , Tengku Mahadi Tengku Sepora 
Published: July 2020

Purpose of the study: This paper embodies research on the introduction of machine translation (MT) into translation teaching and learning from the perspectives of learners and instructors/teachers. Four suppositions of employment of MT in translation classes are observed and examined here: MT as a weak (or peripheral) tool, MT as a useful (or essential) tool; MT as a professional treatment; and MT as a CATI tool.
Methodology: The objective is achieved using an experimental-survey method with a theory of ‘action about reasons’ (technology acceptance model) adapted from Davis, Bagozzi, and Warshaw’s (1989) work as its framework. The survey tool is done through a closed and open-ended questionnaire while the ‘experiment’ takes the form of MT introduction practice exercises in the classroom. One hundred Iranian undergraduate students from a translation course with MT in its syllabus and thirty translation instructors make up the population for this study.
Main Findings: In general, students found MT to be useful for producing their translation and seemed, with good exposure through practice, encouraged to use it. The translation educators too saw its benefits but would only be persuaded seriously to utilize it in their translation classrooms when MT is found to produce a much higher quality of output. Otherwise, the disadvantages might outweigh the benefits and thus make the integration of MT into translation teaching not worthwhile.
Applications of this study: Understanding reservations and motivations of translation students and translation instructors from their responses enable translation educators and programmers to redesign their teaching to lessen the challenges and at the same grow their confidence in handling MT and guide them towards efficient and effective use.
Novelty/Originality of this study: To date, the testing of MT in teaching has been done in language education per se. In this study, MT is examined as a tool for better translation teaching, and not as a mode of translation as opposed to human translation. This lends originality to the study.
Aktivitas Antioksidan Isolat Steroid Hasil Kromatografi Lapis Tipis dari Fraksi n-Heksana Hydrilla verticillata
Authors: Fasya Ahmad Ghanaim , Purwantoro Bagas , Ulya Lulu'atul Hamidatu , Ahmad Mujahidin 
Published: July 2020

Hydrilla verticillata is one of Allah SWT creations that potential as an antioxidant. This study’s objectives were to determine antioxidant activity and identify steroid isolates of n-hexane fraction of H. verticillata. The steroid compounds were extracted using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using n-hexane. The n-hexane fraction was tested phytochemically and separated using thin-layer chromatography (TLC). The steroids compounds were identified using UV-Vis spectrophotometer, FTIR, and LC-MS/MS. The result showed that maceration extraction produced 5.14% yield, whereas n-hexane fraction produce 47.95% yield. Steroid separation through analytical TLC revealed that n-hexane: ethyl acetate (4:1) as the best eluant with 12 spots, while separation using preparative TLC yielded 19 spots. Steroid isolate from TLC preparative has antioxidant activity with EC50 of 5.109 ppm. Identification of steroid compounds using UV-Vis produced maximum wavelengths at 203.9 and 276 nm, while using FTIR indicated the presence of O-H group, geminal dimethyl, C=O, C=C, secondary C-OH, and =C-H (alkene) which might contain steroid compounds. The result of LC-MS/MS showed the presence of β-sitosterol. Hydrilla verticillata merupakan salah satu ciptaan Allah SWT yang memiliki potensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan dan mengidentifikasi senyawa steroid pada isolat hasil pemisahan fraksi n-heksana H. verticillata. Senyawa steroid diekstraksi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi dengan n-heksana. Fraksi n-heksana hasil partisi diuji fitokimia dan dipisahkan senyawanya menggunakan KLT (Kromatografi Lapis Tipis). Identifikasi dilakukan menggunakan UV-Vis, FTIR, dan LC-MS/MS. Hasil penelitian menunjukkan ekstraksi maserasi menghasilkan rendemen 5,14%, sedangkan rendemen partisi n-heksana sebesar 47,95%. Pemisahan steroid menggunakan KLT analitik menunjukkan bahwa variasi eluen terbaik adalah n-heksana: etil asetat (4:1) dengan 12 noda, sedangkan pemisahan KLT preparatif menghasilkan 19 noda. Isolat steroid hasil KLT preparatif memiliki aktivitas antioksidan dengan EC50 5,109 ppm. Identifikasi senyawa steroid menggunakan UV-Vis menunjukkan bahwa panjang gelombang maksimum sebesar 203,9 dan 276 nm, sedangkan untuk identifikasi isolat steroid menggunakan FTIR menunjukkan gugus fungsi O-H, geminal dimetil, C=O, C=C, C-OH sekunder dan =C-H (alkena) yang diduga merupakan senyawa steroid. Hasil LC-MS/MS menunjukkan adanya senyawa steroid β-sitosterol.
Bantuan sosial dan pendidikan kesehatan bagi masyarakat pesisir yang terdampak sosial-ekonomi selama patogenesis Covid-19 di Manggarai
Authors: Tapung Marianus Mantovanny , Regus Max , Payong Marsel Ruben , Rahmat Stefanus Turibus , Jelahu Frederikus Maigahoaku 
Published: July 2020

[Bahasa]: Pandemik Covid-19 telah berdampak pada masyarakat pesisir di wilayah utara dan selatan Manggarai. Mereka mengalami keterpurukan sosial ekonomi selama patogenesis Covid-19. Daya tawar hasil panen di laut dan di ladang mengalami penurunan drastis. Situasi ini membuat masyarakat pesisir mengalami kesulitan dalam menjalani hidup. Persoalan ini menarik untuk dikaji dan menjadi dasar dalam melakukan pengabdian masyarakat dalam bentuk bantuan sosial dan pendidikan kesehatan. Kegiatan pengabdian ini bertujuan untuk memberi bantuan sosial dan pendidikan kesehatan kepada masyarakat pesisir Kegiatan bantuan sosial dan pendidikan kesehatan dilakukan agar masyarakat pesisir bisa terbantu secara sosial ekonomi pada masa pandemi dan kesadaran kritisnya tumbuh terkait bahaya Covid-19. Kegiatan ini juga bertujuan menumbuhkan kesadaran masyarakat akan pentingnya perilaku hidup sehat dan bersih. Dengan menambah asupan makanan yang cukup, tubuh mereka memiliki imunitas yang baik sehingga bisa bertahan dari serangan virus. Kegiatan pengabdian kepada masyarakat pesisir ini dilakukan dengan mengadaptasi dan memodifikasi pendekatan IPOAI (Identifying, Planning, Organizing, Acting, Impact). Hasil kegiatan menunjukkan adanya peningkatan kesadaran masyarakat pesisir akan pentingnya memelihara kesehatan. Bantuan sosial yang diberikan juga membantu meningkatkan asupan gizi sehingga menjaga imunitas tubuh di masa pandemik Covid-19.
Kata Kunci: bantuan sosial, pendidikan kesehatan, dampak sosial ekonomi, Covid-19
[English]: The Covid-19 pandemic has impacted coastal communities in the northern and southern regions of Manggarai. They experienced a socio-economic downturn during the pathogenesis of Covid-19. The bargaining power of harvest in the sea and the fields has decreased dramatically. This situation makes it difficult for coastal communities to live their daily life. This issue is interesting to study and become the basis for this community service program which aims to provide social assistance and health education to coastal communities. The programs were carried out to support economic condition of coastal communities in the pandemic, educate the danger of Covid-19, and raise public awareness of the importance of healthy and clean-living behaviors. For example, adequate food intake will help their bodies have good immunity to survive the virus. This community service program refers the adaptation and modification of the IPOAI approach (Identifying, Planning, Organizing, Acting, Impact). The results show the increase in awareness of coastal communities of the importance of maintaining health. The social assistance also helps to increase nutritional intake and thus helps maintain body immunity during the Covid-19 pandemic.
Keywords: social assistance, health education, social economic impact, Covid-19
Jihad Digital: Pembingkaian Narasi Kontra Radikalisasi NU Online di Dunia Maya
Authors: Sefriyono Sefriyono 
Published: July 2020

The development of digitalization has shifted the institutionalization values patterns from conventional to cyberspace, it is containing radical values through the website which also developed along with the development of digitalization. Radicalization in cyberspace requires the counter-sites which committed to religious moderation. NU Online is one of this counter-site. This study uses qualitative methods with data analysis framing techniques. NU Online distinguishes the radicalization and intolerance narratives in cyberspace is a source of the uproar of the national ideology and disharmony in the interfaith relations. In its prognosis strategy, NU Online develops the narratives such as Islam is very compatible with Pancasila. While in its motivational strategy, NU Online invites all elements of the nation to maintain the integration of the nation by publishing the headline such as “four reasons for rejecting the <em>Khilafah</em>”. This counter-radicalization framing is different from that carried out by panjimas.com as a representation of the radical site
Permintaan Kopi Biji Indonesia di Pasar Internasional
Authors: Manalu Doni Sahat Tua , Harianto Harianto , Suharno Suharno , Hartoyo Sri 
Published: July 2020

Kopi merupakan salah satu komoditas unggulan perkebunan Indonesia setelah kelapa sawit, karet dan kakao dengan jumlah ekspor kopi yang lebih tinggi dibandingkan dengan konsumsi domestik. Tujuan penelitian adalah menganalisis faktor-faktor yang memengaruhi permintaan kopi biji Indonesia di pasar Internasional. Metode analisis data yang digunakan pada penelitian ini adalah model Linear Approximate Almost Ideal Demand System (LA/AIDS) dengan menggunakan data time series dari tahun 1995 hingga 2017 dengan HS 090111. Hasil penelitian menunjukkan bahwa faktor-faktor yang memengaruhi permintaan kopi biji Indonesia di Amerika Serikat adalah harga kopi row, Carea NTM, di Jepang adalah harga kopi Vietnam, populasi Jepang dan NTR Jepang terhadap Dollar, di Jerman adalah harga row dan Carea NTM. Kopi Indonesia bersifat elastis di negara importir utama Amerika Serikat, Jepang dan Jerman. Berdasarkan nilai elastisitas silang kopi Indonesia bersifat inelastis, kopi Indonesia bersifat komplementer dengan kopi Vietnam di pasar Amerika Serikat, sementara di pasar Jepang dan Jerman bersifat substitusi.
DETECÇÃO DAS OCORRÊNCIAS DE FOCOS DE QUEIMADAS E PRODUÇÃO DE MAPAS DE CALOR EM TIMON, MA
Authors: Marques Rafael Jose , Sobrinho Werton Francisco Rios da Costa 
Published: July 2020

O Brasil atualmente passa por uma expansão nas atividades do agronegócio e ao mesmo tempo, mantém as pequenas atividades agrícolas que permanecem ativas, e ambas as atividades ainda se utilizam da técnica mais rudimentar de limpeza de área para plantio e ou para pasto para criação de animal, a prática do fogo, a queimada. Neste âmbito, o Instituto Nacional de Pesquisas Espaciais (INPE) vem cada vez mais sendo relevante com um sistema de detecção de queimadas a partir de imagens de sensores a bordo de satélites polares e geoestacionários. Assim, os chamados focos de calor são detectados e esses dados são utilizados para mapeamentos, controle e prevenção. Neste sentido este trabalho pretende trazer dados das ocorrências no município de Timon (MA), entre os anos de 2014 a 2018, e nestes 5 (cinco) anos foram detectados cerca de 6.405 mil focos de queimadas, identificados pelo INPE. O conhecimento das causas e da frequência desses ocorridos é de extrema importância, principalmente levando-se em consideração que o ponto de partida para a elaboração dos planos de prevenção, é saber quem (ou o que) iniciou o fogo. Assim, este trabalho propõe validar e entender a relação dos focos de calor obtidos pelo INPE e queimadas realmente ocorridas, do município. Analisando os focos de calor disponibilizados pelo INPE.
Effects of Vitamin D Supplementation on Female Vitamin D Deficient Teenagers: A Randomized Clinical Trial
Authors: Ahi Salma , Gholami Fatemeh , Hatami Naser , Golabi Fatemeh 
Published: July 2020

Abstract
Background: Vitamin D deficiency is one of the most prevalent disorders worldwide. Considering the magnitude of growth in adolescence, the aim of this study was to ascertain the prevalence of vitamin D deficiency and discover the association between anthropometric indices and vitamin D levels and the effect of vitamin D treatment on anthropometric indices in adolescent girls. Method: we performed this randomized clinical trial study (approved by Iranian Registry of Clinical Trials with code of IRCT20200615047785N2) conducting 313 high school girl students in a random cluster sampling from Jahrom city schools. Blood samples were collected from participants to determine the serum level (OH) D25. We divided vitamin D deficient patients into two groups: control who received placebo (n=150) and intervention group (n=150) who were prescribed one tablet of 50,000 units of vitamin D per week for eight weeks. Anthropometric indices of participants were measured before and after the intervention. Datas were analyzed by SPSS software version 19.Results: The prevalence of vitamin D deficiency was 95%. Body mass index had no significant difference before the intervention in both groups (P = 0.76). After intervention in the case group, body mass index increased significantly (P = 0.01), but there was no significant difference in the control group after treatment (P = 0.42). There was no significant difference in waist circumference, height and weight before and after the intervention in both groups (P > 0.05). There was also a weak but significant correlation between height, weight, and baseline 25OHD levels of participants.Conclusion: The results of this study showed that there is a reverse and significant relationship between height and weight index with 25OHD. Further monitoring and prolonged studies with extended follow ups might improve the anthropometric parameters after treatment.
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice
Authors: Tian Jing-Hui , Patel Nita , Haupt Robert , Zhou Haixia , Weston Stuart , Hammond Holly , Logue James , Pornoff Alyse , Norton James , Guebre-Xabier Mimi , Zhou Bin , Jacobson Kelsey , Maciejewski Sonia , Khatoon Rafia , Wisniewska Malgorzata , Moffitt Will , Kluefel-Stahl Stefanie , Ekechukwu Betty , Papin James , Boddapati Sarathi , Wong C. Jason , Piedra Pedro , Frieman Matthew , Massare Michael , Fries Louis , Bengtsson Karin Lovgren , Stertman Linda , Ellingsworth Larry , Glenn Gregory , Smith Gale 
Published: July 2020

Abstract
The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd immunity to control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length spike (S) protein, stabilized in the prefusion conformation. Purified NVX-CoV2373 S form 27.2 nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice and baboons, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicits high titer anti-S IgG that is associated with blockade of hACE2 receptor binding, virus neutralization, and protection against SARS-CoV-2 challenge in mice with no evidence of vaccine-associated enhanced respiratory disease (VAERD). NVX-CoV2373 vaccine also elicits multifunctional CD4+ and CD8+ T cells, CD4+ T follicular helper T cells (Tfh), and the generation of antigen-specific germinal center (GC) B cells in the spleen. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2327 with Matrix-M (NCT04368988).
Landslide in rocks of Jodhpur Group at Masuria Hill in Jodhpur, Western Rajasthan, India: Its causes and threat to significant Georesources
Authors: Mathur Saurabh , Sudhanshu  , Singh Suraj Kumar , C.P Khichi , Mathur S. C. 
Published: July 2020

Abstract
The ever first disastrous landslide at Masuria Hill (MH) damaged many houses and properties on 4th October 2019 in surrounding residential colonies of Masuria area in the Jodhpur city, Western Rajasthan India. Present landslide not only created panic among people but also damaged properties and significant georesources which is a serious concern for future. Geologically, MH is represented by rhyolite of Malani igneous suite (MIS) of Cryogenian age which is overlain by siliciclastic rocks of Jodhpur Group (JG) of Ediacaran age of Marwar Supergroup (MSG). Landslide occur in horizontally disposed rocks of Umed Bhawan Formation (UBF) of JG. UBF is divided into 4-18m thick clay dominated soft sediments zone with sheet and release joints at the base. It is followed by 24-72m thick rigid sand zone having orthogonal jointing. This disposition of soft and rigid pattern of sedimentation of UBF is identified as the key horizons responsible for the landslide with shale horizon as the failure plane. Causes of landslide can be explain based on the model of BPSZ (Bedding Parallel Shear Zone). BPSZ is attributed to three main mechanisms: liquefaction, mass wasting and shear stresses that caused the landslide at MH. Study further reveal that residential area surrounding MH and other seven hills having similar geological disposition are under great threat to future landslide in Jodhpur. Paper also embodies characteristics of georesources having educational and cultural values which are under great threat to landslide along with appropriate hazard mitigation measures.