bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Keluarga Terhadap Perilaku Mahasiswa yang Mengkonsumsi Minuman Beralkohol di Kabupaten Jember
Authors: Rahma Nina Ainur , Gani Husni Abdul , Ririyanti Mury 
Published: November 2020

Adolescents in the age range of 17-21 years are generally students, who are expected to have good cognitive skills and be able to solve problems effectively. Teenagers who are unable to solve problems sometimes do something that is harmful to themselves such as consuming alcoholic beverages. The role of the family such as parenting and family conditions is one of the causes of adolescents consuming alcoholic beverages. This study aims to determine the role of families in the behavior of students who consume alcoholic beverages in Jember Regency. The theory used by researchers is Social Learning from Bandura. This research is a descriptive study with a qualitative approach. Determination of research informants using snowball techniques. Data collection uses in-depth interviews, documentation and passive participatory observation. Based on the results of the study it was found that the all-free parenting style, lack of trust given by parents to involve children in making decisions and ineffective time spent by parents for families so that children behave deviant. Keywords: Family, teenagers, alcoholic drinks, social learning
Kadar Kolesterol pada Mencit (Mus-Musculus) Diabetes Setelah Konsumsi Ekstrak Rumput Laut Coklat (Phaeophyta)
Authors: Fransiska Irene , Indahyani Didin Erma , Handayani Ari Tri Wanodyo 
Published: November 2020

In the case of Diabetes Mellitus, it will trigger some changes in lipid metabolism and lipoprotein composition, one of them is cholesterol. Cholesterol is a lipid that plays an important role in the structure of cell membranes. Seaweed contains bioactive components of flavonoids which reduce cholesterol levels. Brown seaweed contains bioactive components of alkaloids, flavonoids, triterpenoids, saponins, phenol hydroquinone, tannins, chlorophyll and β-carotene pigments. The bioactive component of brown seaweed also has strong antioxidant activity that can prevent damage caused by oxidative stress on pancreatic β cell function and acts as a trap for various free radicals and can reduce diabetic rat lipid peroxidation. This study to analyze the effect of giving brown seaweed extract on cholesterol levels in diabetic mice.This study was divided into 4 sample groups, namely the normal group, negative controls (diabetic mice), positive controls (diabetic mice + 1.3 mg / 20 gr BB metformin), K1 (diabetic mice + brown seaweed extract). The seaweed dose of 10mg / 20grBB is given on a daily basis for 21 days. Checking blood cholesterol levels in serum using the POD CHOD method and measured using biolysers. Diabetic mice with brown seaweed extract were significantly (p <0.05) lower cholesterol level of 68.94 mg / dL than diabetic mice 81.75 mg / dL. It was concluded that brown seaweed extract had an effect on reducing total cholesterol levels in diabetic mice.
Keywords : Cholesterol levels, Diabetic mice, Brown Seaweed
FACTORS ASSOCIATED WITH NUTRITIONAL STATUS OF CHILDREN UNDER FIVE YEARS OF AGE IN GUNUNGSITOLI IDANOI PRIMARY HEALTHCARE CENTER
Authors: Ziliwu Novrin Senselia Putri , Anggraeni Lina Dewi , Lina Rosa Nora 
Published: November 2020

The number of children under five years of age suffering from underweight was 28.0% in Gunungsitoli district. Out of six primary Healthcare centers in the district, Gunungsitoli Idanoi Primary Healthcare Center Healthcarewas one of the six primary healthcare centers with the highest malnutrition prevalence. Sixty-four children under five years of age there Healthcaresuffered from malnutrition. This study aimed to identify factors associated with the nutritional status of children under five in Gunungsitoli Idanoi Primary Healthcare Center, Gunungsitoli district. It was an analytical survey with a cross-sectional approach conducted in Gunungsitoli Idanoi Primary Healthcare Center in February 2019. Data were collected using a questionnaire. This study had samples as many as 246 mothers of children under five years of age selected using a purposive random sampling technique. The bivariate analysis indicates the nutritional status of children under five was significantly associated with mother’s employment status (p=0.043) and family size (p=0.015). While the nutritional status of children under five had no significant association with mother’s knowledge of nutrition (p=0.485), mother’s education (p=0.616), family income (p=0.511), infectious disease (p=0.913), and history of breastfeeding (p=0.847). Mother’s employment status and family size affected the nutritional status of children under five. The primary Healthcare center should cooperate with stakeholders across sectors, especially conduct training for improving economic business skills of the people in the village, and promote family planning program for couples of childbearing age. Keywords: Breastfeeding, children under five years of age, underweight, mother’s knowledge, mother’s employment.
PREVALENCE AND FACTORS ASSOCIATED WITH HYPERTENSION AMONG HEALTH WORKERS OF CENTRAL HOSPITALS IN NEPAL
Authors: Ghimire Prakash , Khadka Alisha , Anuwatnonthakate Amornrat , Trongsakul Supaporn 
Published: November 2020

Hypertension is a significant public health issue considered as the world's biggest killer among the working-age group. Health workers are one of the working groups who are facing several factors in their lives that could induce hypertension among them. Nevertheless, there is a lack of information about hypertension among Nepalese health workers. Therefore, this cross-sectional study aimed to determine the prevalence and factors associated with hypertension among health workers of central hospitals in Nepal. A total of 422 health workers aged ≥30 years from seven central hospitals of Nepal were selected using a proportionate stratified systematic random sampling method. Information regarding characteristics (socio-demographic, clinical, behavioral, occupational, and perceived stress) of participants were obtained by face to face interviews using a questionnaire after getting informed written consent. Participant's blood pressure and body mass index were measured based on the World Health Organization STEP Surveillance Manual. Binary logistic regression model was used to identify the associated factors of hypertension. The prevalence of hypertension was 35.31% (95% CI: 30.70%-40.10%). After controlling potential confounding factors through multivariate analysis, seven factors (increasing age, low educational level, being married, low fruit & vegetable consumption, low physical activity, alcohol use, and increased perceived stress) were found as significant independent predictors of hypertension. In conclusion, hypertension is highly prevalent among Nepalese health workers. Effective behavioral change interventions and routine health screening programs focusing on hypertension should be implemented to control hypertension among this neglected group, Nepalese health workers. Keywords: Health Workers, Hypertension, Perceived stress, Physical activity, Prevalence, Nepal
Reliability of Tibiofemoral Contact Area and Centroid Location in Upright, Open MRI
Authors: Schmidt Andrew , Stockton David J. , Hunt Michael A. , Yung Andrew , Masri Bassam A. , Wilson David R. 
Published: November 2020

Abstract
Background:Imaging cannot be performed during natural weightbearing in biomechanical studies using conventional closed-bore MRI, which has necessitated simulating weightbearing load on the joint. Upright, open MRI (UO-MRI) allows for joint imaging during natural weightbearing and may have the potential to better characterize the biomechanical effect of tibiofemoral pathology involving soft tissues. However open MRI scanners have lower field strengths than closed-bore scanners, which limits the image quality that can be obtained. Thus, there is a need to establish the reliability of measurements in upright weightbearing postures obtained using UO-MRI.Methods:Knees of five participants with prior anterior cruciate ligament (ACL) rupture were scanned standing in a 0.5T upright open MRI scanner using a 3D DESS sequence. Manual segmentation of cartilage regions in contact was performed and centroids of these contact areas were automatically determined for the medial and lateral tibiofemoral compartments. Inter-rater, test-retest, and intra-rater reliability were determined and quantified using intra-class correlation (ICC3,1), standard error of measurement (SEM), and smallest detectable change with 95% confidence (SDC95). Accuracy was assessed by using a high-resolution 7T MRI as a reference.Results:Contact area and centroid location reliability (inter-rater, test-retest, and intra-rater) for sagittal scans in the medial compartment had ICC3,1 values from 0.95-0.99 and 0.98-0.99 respectively. In the lateral compartment, contact area and centroid location reliability ICC3,1 values ranged from 0.83-0.91 and 0.95-1.00 respectively. The smallest detectable change in contact area was 1.28% in the medial compartment and 0.95% in the lateral compartment. Contact area and centroid location reliability for coronal scans in the medial compartment had ICC3,1 values from 0.90-0.98 and 0.98-1.00 respectively, and in the lateral compartment ICC3,1 ranged from 0.76-0.94 and 0.93-1.00 respectively. The smallest detectable change in contact area was 0.65% in the medial compartment and 1.41% in the lateral compartment. Contact area was accurate to within a mean absolute error of 11.0 mm2.Conclusions:Knee contact area and contact centroid location can be assessed in upright weightbearing MRI with good to excellent reliability. The lower field strength used in upright, weightbearing MRI does not compromise the reliability of tibiofemoral contact area and centroid location measures.
MRI Outcomes of Nonsurgical Treatment of Giant Lumbar Disc Herniation: A Prospective Clinical Study
Authors: Ma Zhi Jia , Yu Peng Fei , Dai Yu Xiang , Feng Qiu Xiang , Wu Li Ming , Shen Xue Qiang , Jiang Hong , Liu Jin Tao 
Published: November 2020

Abstract
Background: The phenomenon of lumbar disc herniation resorption is increasingly being reported, but the occurrence of this phenomenon cannot currently be accurately predicted.Methods: We acquired magnetic resonance imaging (MRI) of patients with giant lumbar disc herniation from January 2018 to December 2019, and analyzed the prognostic value of measurements performed on the images. The patients underwent conservative treatment according to the doctor’s decision. The imaging assessments included Komori points, MSU type, Iwabuchi type, the presence of a “bull’s eye” sign on contrast-enhanced MRI, Modic type classification, initial imaging prominence rate, and maximum level projection area. Post-treatment MRI was reviewed to evaluate the outstanding prominence rate and the maximum level projection area, thereby allowing calculation of the intervertebral disc absorption rate after treatment. The rate of patients undergoing later surgery was also recorded.Results: Seventy-six patients (46 males and 30 females, aged 14–65 years [mean 37.79 ± 10.60]) were included in this study, 12 of whom underwent surgery, giving a surgical rate of 15.79%. All patients were followed up for more than 9 months. The outburst rate was 84.41% ± 14.72%. The absorptivity rate of the 64 patients under conservative treatment was 38.35% ± 40.64%, with the absorptivity of the patients with Iwabuchi type 1 and a bull’s eye sign being significantly higher than the average rate (P < 0.01).Conclusions: The resorption of giant lumbar disc herniation is a natural process. Imaging findings showed Iwabuchi type 1 and a positive bull’s eye sign on contrast-enhanced MRI to be associated with an increased probability of resorption.
Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasis
Authors: Nataraj Nishanth , Noronha Ashish , Lee Joo , Ghosh Soma , Raju Harsha Raj Mohan , Sekar Arunachalam , Zuckerman Binyamin , Lindzen Moshit , Srivast Swati , Selitrennik Michael , Livneh Ido , Drago-Garcia Diana , Rueda Oscar , Caldas Carlos , Lev Sima , Geiger Tamar , Ciechanover Aaron , Ulitsky Igor , Seger Rony , Ruppin Eytan , Yarden Yosef 
Published: November 2020

Abstract
To identify genetic events driving breast cancer progression, we performed multi-omics integrated analyses that identified overexpression of nucleoporin-93, a nuclear pore component. Here we show that NUP93 overexpression enhances trans-endothelial migration and matrix invasion in vitro, along with metastasis in animal models. These findings were supported by analyses of naturally occurring activating NUP93 mutations and inactivating nephrotic syndrome mutations. Mechanistically, NUP93 activation enhanced the ultimate nuclear transport step shared by multiple signaling pathways, including TGF-beta/SMAD, EGF/ERK and TNF/NF-κB. Likewise, NUP93 can boost nuclear transport of beta-catenin, as well as elevate expression and inhibit degradation of this co-activator. The emerging addiction to nuclear transport exposes vulnerabilities of tumors overexpressing NUP93. Congruently, we report that myristoylated peptides corresponding to the nuclear translocation signals of SMAD and ERK inhibited growth and metastasis. Our study illuminates a previously unappreciated hallmark of advanced tumors, which derive benefit from unblocking a set of nucleocytoplasmic bottlenecks.
How Did the Restrictions Effect the Orthopaedic Trauma Surgery During Covid-19 Pandemic at a Level 1 Tertiary Trauma Hospital?
Authors: Kilic Bulent , Gulabi Deniz , Agar Anıl , Buyukdogan Halil , Sahin Adem , Eren Erdal , Erturk Cemil 
Published: November 2020

Abstract
BackgroundThe aim of the study was to evaluate and compare the demographic characteristics, the trauma mechanism, and fracture types between patients under 20 years of age, 20-65 years of age, and over 65 years of age between the COVID-19 pandemic and the pre-pandemic period.MethodsPatients who were hospitalized and treated for orthopedic treatment between 10 March and 1 June during the pandemic period were retrospectively analyzed. Control group consisted of patients admitted to the hospital in the same time interval in 2019.The patients were divided into three groups, under 20 years of age, between 20-65 years of age, and over 65 years of age. The patients’ data included age, gender, trauma mechanism, fracture type, any COVID-19 radiological or clinical symptoms.ResultsThe number of patients > 65 years old admitted to orthopaedic trauma center were high at pandemic interval compared to pre-pandemic time. When the groups were compared for patients of 20-65 years old; there was a significant difference for the fracture type (p<0.05). Lower extremity fractures were high at pre-pandemic group whereas multiple traumas were high at pandemic group. For sub-group 20-65 ages, low energy traumas were higher at pre-pandemic group whereas high energy traumas were more frequent at pandemic group.ConclusionWe observed a decrease in fracture admission to ortopaedic trauma centers during COVID-19 pandemic for subgroups of < 20 years old and 20-65 years old ages, whereas there was a significant increase for > 65 years old age, most of them related to the osteoporotic hip fractures. So that older age group should be encouraged to mobilized at home and have permission to walk and make physical activity to avoid osteoporosis for a limited time daily.
Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria
Authors: Cheng-fei Zhao , Wang Xuewen , Yu Luying , Wu Lina , Hao Xiaoli , Qicai Liu , Li-qing Lin , Huang Zhengjun , Weng Shaohuang , Liu Ailin , Lin Xinhua 
Published: November 2020

Abstract
Quaternized carbon quantum dots (qCQDs) with broad-spectrum antibacterial activity were synthesized by a simple green “one-pot” method using dimethyl diallyl ammonium chloride and glucose as reaction precursors. The qCQDs showed satisfactory antibacterial activity against both gram-positive and gram-negative bacteria. In rat models of wounds infected with mixed bacteria, qCQDs obviously restored the weight of rats, significantly reduced the death of rats from severe infection, and promoted the recovery and healing of infected wounds. Biosafety tests confirmed that qCQDs had no obvious toxic and side effects during the testing stage. The analysis of quantitative proteomics revealed that qCQDs mainly acted on the ribosomal proteins of gram-positive bacteria and significantly down-regulated the metabolization-related proteins of gram-negative bacteria. Real-time quantitative PCR verified the expression levels of genes corresponding to the proteins with significant differences expressed by the two species of bacteria after treated with qCQDs. The variation trend of the detected genes was consistent with the results of proteomics, meaning that qCQDs played the antibacterial effect on bacteria with a new antibacterial mechanism.
Landslide Susceptibility Analysis: A Case Study of Nainital Municipal Area
Authors: Bhattacharyya Prashasti , DasGupta Shubhanita , Das Sourav , Paul Suchismita 
Published: November 2020

Abstract
Landslides are one of the most recurrent natural phenomena that are of overwhelming significance in the Himalayas. The Himalayan terrain being under severe transmutation by human interference and excess urban penetration has led to triggering of landslides along with causing colossal damage to property and loss of life. Immense risk looms large all along the Himalayas with cumulating conditions that build the potentiality to landslides. The study of landslides has drawn worldwide attention mainly due to the aggravating socio-economic consequences as well as the increasing pressure of urbanization on the mountain environment. In order to reduce the damage and manage vulnerable areas, there is imperative need to formulate comprehensive Landslide Vulnerability and Susceptibility Zonation maps for different areas of the Himalayan region emphasizing the urbanized and burgeoning pockets. The concept of landslide susceptibility and landslide susceptibility assessment have been introduced in the past couple of decades and various methodologies have been developed for evaluating the devastating power of landslides and its associated processes. The ultimate aim is to evolve a method suitable for specific areas through which appropriate management measures can be taken to reduce the risk from potential landslides. Any approach towards LSZ would require identification of the conditions leading to slope failure, their systematic mapping and evaluation of their relative contributions by amalgamation of all factors in the ultimatum. The aim of this paper is to assess the various landslide vulnerability factors in Nainital Municipality area on raster-based GIS platform and generate landslide vulnerability and susceptibility maps. To achieve the objective, a detailed inventory of maps based on all parameters assessed has been generated of the study area from the satellite imageries and field data. The accuracy of results is being validated by constant observation and prediction accuracies.
Treatment of Bacterial Vaginosis: A Comparison of Metronidazole and Clindamycin on Human Anaerobic Bacteria and Lactobacilli
Authors: Li Ting , Wang Fengjuan , Zhang Zhan , Zong Xiaonan , Bai Huihui , Liu Zhaohui 
Published: November 2020

Abstract
Background: Bacterial vaginosis (BV) is a disturbance of vaginal microflora that affects up to one-third of women of reproductive age. To compare the frequencies, clinical characteristics, and antimicrobial susceptibilities of vaginal microbes before and after metronidazole and clindamycin therapy. Results: A total of 140 premenopausal women with BV and 10 healthy women who underwent routine gynecological examination and were examined by the Vaginal Microecology Evaluation System at Beijing Obstetrics and Gynecology Hospital between October 2018 and February 2019 were recruited for this study. Gardnerella (G.) vaginalis and Lactobacillus isolates were isolated and cultured. Clinical isolates were then evaluated for antimicrobial susceptibilities in vitro to metronidazole and clindamycin. Nested PCR and denaturing gradient gel electrophoresis were used to characterize the quantitative structure of bacterial signatures. Facultatively anaerobic bacteria including G. vaginalis (40.31 %), Prevotella isolates (14.89 %) and Atopobium (A.) vaginae (4.65 %) were among the most frequently isolated species among the 129 samples. The clinical isolates had a significantly higher susceptibility rate to clindamycin than to metronidazole (80.00% vs 32.14%; P = 0.002) in vitro. Conclusions: Given metronidazole sparing Lactobacillus, metronidazole has better vaginal acidification than clindamycin in vivo. The CDC-recommended regimens for BV management with metronidazole and clindamycin were demonstrated to have roughly equivalent clinical efficacy. We recommend administering Lactobacillus probiotics 5 to 7 days after the last antibiotic dose when choosing clindamycin therapy.
The Clinical Application of Filmarray Respiratory Panel in Children with Acute Respiratory Tract Infections in a Pediatric Hospital
Authors: Zhang Hong , Pan Fen , Wang Bingjie , Shi Yingying , Xu Qi 
Published: November 2020

Abstract
Background: Acute respiratory tract infections (ARTIS) are the common diseases in children and common methods frequently fail to identify the infectious etiology especially for viruses. The Filmarray respiratory panel (FARP) can reliably and rapidly identify viruses and bacterial pathogens. This study is to evaluate the performance and clinical significance of FARP in children with ARTIS.Methods: A total of 90 nasopharyngeal secretion (NPS) samples from children with ARTIS were enrolled. The FARP assay for 17 pathogens and other common methods including direct fluorescence assay (DFA) were performed to analyze these samples. Clinical data of all patients was also collected and evaluated.Results: Among the 90 samples, 58 samples (64.4%) were positive for 13 pathogens by FARP and 18 positive samples were detected with multiple-virus (31.3%, 18/58). Human rhinovirus/ enterovirus (21.0%%, 17/58) were predominant pathogen, followed by adenovirus (18.5%). Higher proportions of various pathogens were identified in the infant and toddler (0–2 years) groups with human rhinovirus/enterovirus being mostly virus. Adenovirus were common in the group aged 3–5 years, but only three pathogens including M.pneumoniae, respiratory syncytial virus, and adenovirus were also found in age group (6-14 years). Among 58 FARP positive patients, significant differences were in antibiotic prescription and use of hormone the single-organism-positive group and the multi-organism-positive group (P<0.05). Furthermore, there was significant difference in use of anti-virus and usage of hormone between severe respiratory infections group and non severe respiratory infections group (P<0.05). Conclusions: This study demonstrated that FARP can provide the rapid detection of respiratory virus and atypical bacteria for children, especially with severe respiratory tract infections.