bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home mechanical ventilation in complex chronic disease in children – what is the impact on the sleep quality of the caregivers?
Authors: Gonçalves Raquel Santos , Martins Cristiana , Borges Ana , Madureira Núria , Cancelinha Cândida 
Published: January 2020

Abstract
Background The role caregivers of children with complex chronic disease play may be linked to important sleep disturbances, which may threaten the long-term quality care to their children.Aim Evaluation of the sleep quality of the caregivers of children with complex chronic disease under home mechanical ventilation.Design Observational and analytic study (October 2018 – January 2019).Setting/Participants We assessed 33 caregivers of patients with complex chronic disease under home mechanical ventilation for ≥3 months, followed in the Pneumology Clinic of a tertiary paediatric hospital. Evaluation instrument: Pittsburgh Sleep Quality Index (Portuguese version).Results Most of the caregivers were mothers (88%), median age of 40 years. Most of the children were male (70%), median age of 11 years. The main diagnostic group was genetic/polymorphic syndrome (46%); 52% belonged to group 2 (Association for Children with Life-Threatening or Terminal Conditions). There was a discrepancy between the subjective sleep quality ("Good" in 64%) and the Pittsburgh Sleep Quality Index score ("Poor" in 72%), with significant percentage of daytime sleepiness/dysfunction (75%). The increase in daily hours of ventilation seems to lead to a lower sleep quality (p = 0.669). Caregivers with sleep disorder had lower sleep quality values.Conclusions The sleep quality of the caregivers of children under home mechanical ventilation has ​​similar values to specific groups described in literature, but lower than that of the healthy Portuguese population. It is essential to raise the professionals’ awareness for the evaluation of sleep quality of caregivers, since it may not be adequately perceived by them.
The Effect of Health System Responsiveness on Health Outcome: Evidence from Spain
Authors: Abreha Solomon Kibret 
Published: January 2020

Abstract
Background For the last two decades, the health system responsiveness has gained attention in the health policy area. However, little is known about its effect within the healthcare system on health outcome. This study aims to investigate the influence of health system responsiveness on self-assessed health. Particularly it examines if self-assessed health is affected by satisfaction with communication, dignity and waiting time.Methods The study used data from the Spanish Health Care Barometer Survey (SHBS) between 2011 and 2013. The Ordered Probit and the Hierarchical Ordered Probit (HOPIT) model was used to model anchoring vignettes and to control the problem of reporting heterogeneity arises from self-reported health.Results The result suggests a strong positive association between reporting very good self-assessed health and most of the domains of health system responsiveness. Specifically, after adjusting for reporting heterogeneity, satisfaction with waiting time and communication were found to be statistically significant and positively associated with reporting better self-assessed health for respondents in primary care and hospital care settings, respectively in Spain. The marginal effect of a one unit increase in satisfaction with waiting time in primary care and communication in hospital care is associated with a 2% and 4% increase in the in the likelihood of reporting very good health status respectively, keeping other variables constant.Conclusions Overall, the result suggests that improving patient’s satisfaction with health systems responsiveness may have a positive influence on patients’ health outcomes.
Occupational Identity, Job Satisfaction and Their Effects on Turnover Intention among Chinese Pediatricians: A Cross-sectional Study
Authors: Deng Wanjun , Feng Zhichun , Yao Xinying , Yang Tingting , Jiang Jun , Wang Bing , Lin Lan , Zhong Wenhao , Xia Oudong 
Published: January 2020

Abstract
Objectives This study contributes to research on the paediatrician shortage by examining occupational identity, job satisfaction and their effects on turnover intention among pediatricians in China. Methods This study employed a multi-stage stratified random sampling method to conduct a questionnaire survey. Of the 4906 survey recipients, valid data were collected from 4198 of the respondents (85.6%). Participants were from seven regions of China (south, central, north, east, northwest, southwest, northeast). Pediatricians who volunteered and provided informed, written consent participated.We analysed the collected data with descriptive analyses, one-way analysis, and pearson correlation analysis in SPSS 23.0; common method bias in AMOS 24.0; and mediating effect analysis in SPSSMARO.Results There were significant differences among the respondents in terms of TI based on age, education, marital status, region, type and grade of practice setting, professional title, years in practise, workload, rest days, and monthly income. Occupational identity and job satisfaction were both negatively related to turnover intention, and occupational identity was positively correlated with job satisfaction(r1=-0.601, p<0.001; r2=-0.605, p<0.001). And the result also showed that job satisfaction plays a mediating role in the association between occupational identity and turnover intention among Chinese pediatricians. Conclusions To reduce turnover intention among pediatricians in China, it is crucial to focus on three aspects: work condition, workload and salary. We suggest healthcare managers should increase investment in pediatric, carry out reforms on salary mechanism and pay more attention to female and young pediatricians.
Genomic Analysis Of Spanish Wheat Landraces Reveals Their Variability And Potential For Breeding
Authors: Pascual Laura , Ruiz Magdalena , López-Fernández Matilde , Pérez-Peña Helena , Benavente Elena , Vázquez José Francisco , Sansaloni Carolina , Giraldo Patricia 
Published: January 2020

Abstract
Background
One of the main goals of the plant breeding in the 21 st century is the development of crop cultivars that can maintain current yields in unfavorable environments. Landraces that have been grown under varying local conditions include genetic diversity that will be essential to achieve this objective. The Center of Plant Genetic Resources of the Spanish Institute for Agriculture Research maintains a broad collection of wheat landraces. These accessions, which are locally adapted to diverse eco-climatic conditions, represent highly valuable materials for breeding. However, their efficient use requires an exhaustive genetic characterization. The overall aim of this study was to assess the diversity and population structure of a selected set of 380 Spanish landraces and 52 reference varieties of bread and durum wheat by high-throughput genotyping.
Results
The DArTseq GBS approach generated 10K SNPs and 40K high-quality DArT markers, which were located against the currently available bread and durum wheat reference genomes. The markers with known locations were distributed across all chromosomes with relatively well-balanced genome-wide coverage. The genetic analysis showed that the Spanish wheat landraces were clustered in different groups, thus representing genetic pools providing a range of allelic variation. The subspecies had a major impact on the population structure of the durum wheat landraces, with three distinct clusters that corresponded to subsps. durum , turgidum and dicoccon being identified. The population structure of bread wheat landraces was mainly biased by geographic origin.
Conclusions
The results showed broader genetic diversity in the landraces compared to a reference set that included commercial varieties and higher divergence between the landraces and the reference set in durum wheat than in bread wheat. The analyses revealed genomic regions whose patterns of variation were markedly different in the landraces and reference varieties, indicating loci that have been under selection during crop improvement, which could help to target breeding efforts. The results obtained from this work will provide a basis for future genome-wide association studies.
PEDIATRIC HYPERSENSITIVE PNEUMONITIS POSITIVE EXPERIENCE IN MANAGEMENT
Authors: LEV N. S. , DIAKOVA S. E. , KOSTYUCHENKO M. V. , MIZERNITSKY Y. L. , ROZINOVA N. N. , SOKOLOVA L. V. 
Published: January 2020

Hypersensitive pneumonitis (HP) is an interstitial lung disease occuring in childhood. This article demonstrates own long-running monitoring of a girl with HP at the age of 8. The development of the disease is linked to the home ecology. The diagnosis was based on data from the history, clinical symptoms with respiratory deficiency and crepitating wheezing in the lungs, characteristicfunctional and X-ray manifestations; it was proved by detection in the plasma of the blood of specific immunoglobulins of class G to cause-significant allergens. Elimination interventions and adequate treatment have enabled positive dynamics to be achieved during the disease
An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth
Authors: Farook Fathima Fazrina , M. Nizam Mohamed Nuzaim , Alshammari Abdulsalam 
Published: January 2020

Background:Phenytoin induced gingival overgrowth, a side effect with multifactorial aetiology, is characterized by an increase in the volume of extracellular tissues, particularly collagenous components, with varying degrees of inflammation.Objective:The aim of this paper is to review the available literature regarding the pathophysiological mechanisms of phenytoin induced gingival overgrowth.Methods:A thorough literature search of the PubMed/ Embase/ Web of science/ Cochrane central database was conducted to identify the mechanisms involved in the process of phenytoin-induced gingival overgrowth using the following keywords: Phenytoin; Anticonvulsant; Gingival Overgrowth; Gingival Enlargement, Gingival Hyperplasia; Drug Induced Gingival Enlargement; Drug Induced Gingival OvergrowthResults:According to the available evidence, several mechanisms have been proposed addressing the pathophysiological mechanism of phenytoin induced gingival overgrowth both at a cellular and molecular level. Evidence suggests that the inflammatory changes in the gingival tissues orchestrate the interaction between phenytoin and fibroblasts particularly resulting in an increase in the extracellular matrix content.Conclusion:However, the mechanism of production of inflammatory mediators is not fully understood. This, together with the high prevalence of Phenytoin induced gingival overgrowth, warrants further research in this area in order to develop treatment and preventive strategies for the management of this condition.
Diseñar banquetas accesibles para todos
Authors: Boils Morales Guillermo 
Published: January 2020

<p>Una causa importante de que las banquetas en las ciudades mexicanas sean inadecuadas, insuficientes y con frecuencia hasta peligrosas, se origina en el diseño de quienes las proyectaron. Asunto que se torna más grave aún, cuando se las realizó sin diseño previo alguno, en especial en tratándose aquellos usuarios que son personas aluna discapacidad motora o visual. Estas páginas se ocupan de manera especial de examinar esas deficiencias en la materialización de las banquetas, derivadas de la falta de diseño o de un diseño mal planeado. Asimismo, el artículo da cuenta de los principales obstáculos que afrontan los transeúntes, mismos que se magnifican para las personas que se mueven en silla de ruedas o carecen de la vista.</p>
La unión de arquitectos socialistas y su proyecto de ciudad obrera (1938)
Authors: Márquez Soriano Jesús Nazaret 
Published: January 2020

<p>En septiembre de 1938, un grupo de jóvenes arquitectos comprometidos con el problema de la vivienda destinada para las clases más vulnerables, presentó en el XVI Congreso Internacional de Planificación y de la Habitación su <em>Proyecto de Ciudad Obrera</em>, en el cual propusieron habitaciones cómodas, higiénicas y funcionales; tomando en cuenta una organización interna que correspondía a un modelo de vida de carácter comunitario el cual definiría el diseño urbano y arquitectónico de los edificios de vivienda y de trabajo. De esta manera, el proyecto de la Unión de Arquitectos Socialistas vendría a ofrecer una novedosa propuesta en la década de 1930, que se sumaría a los esfuerzos de otros arquitectos por resolver el problema de la habitación en la Ciudad de México.</p>
Kajian Etnobotani Suku Euphorbiaceae Yang Dimanfaatkan Oleh Suku Pekurehua Di Desa Wuasa Dan Kaduwaa Kecamatan Lore Utara Kabupaten Poso Sulawesi Tengah
Authors: Adhil Adhil , Iqbal Moh. , Ramadanil Ramadanil 
Published: January 2020

Penelitian mengenai Kajian Etnobotanisuku Euphorbiaceae yang dimanfaatkan oleh masyarakat suku Pekurehua di desa Wuasa dan Kaduwaa Kecamatan Lore Utara Kabupaten Poso Sulawesi Tengah dilakukan dengan metode snowball sampling pada bulan januari sampai Maret 2018. Penelitian ini bertujuan untuk mengetahui pemanfaatan jenis tumbuhan suku Euphorbiaceae di desa Wuasa dan desa Kaduwaa Kecamatan Lore Utara Kabupaten Poso Sulawesi Tengah. Pengambilan sampel dilakukan dengan cara mewawancarai, memberikan kuisioner dan pengamatan langsung di lapangan. Identifikasi Dilakukan Di Laboratorium Biodiversitas Jurusan Biologi FMIPA UNTAD. Hasil penelitian ini menunjukkan bahwa terdapat 10 genus dari 17 jenis tumbuhan suku Euphorbiaceae yang dimanfaatkan oleh masyarakat suku Pekurehua sebagai bahan pangan, obat-obatan, bahan bangunan, kayu bakar dan sebagai tanaman hias.
Penerapan Metode Boosting Pada Cart Untuk Mengklasifikasikan Korban Kecelakaan Lalu Lintas Di Kota Palu
Authors: Susiana Luluk , Utami Iut Tri , Junaidi Junaidi 
Published: January 2020

Kota Palu sebagai ibu kota Provinsi Sulawesi Tengah dengan kecelakaan lalu lintas yang cukup tinggi yang setiap tahunnya memiliki kematian sekitar 365 jiwa. Kecelakaan lalu lintas dipengaruhi oleh beberapa faktor, diantaranya jenis pelanggaran, jenis kecelakaan, dan lain-lain. Tujuan yang akan dicapai dalam penelitian ini adalah untuk menentukan ketepatan klasifikasi pada korban kecelakaan lalu lintas di Kota Palu dengan menggunakan metode boosting serta faktor-faktor yang mempengaruhinya. Hasil dari penelitian ini menunjukkan bahwa ketepatan klasifikasi metode boosting sebesar 82% dan metode CART sebesar 77,9%. Hasil tersebut menunjukkan bahwa metode boosting dapat meningkatan tingkat akurasi. Sedangkan faktor-faktor yang mempengaruhi korban kecelakaan lalu lintas di Kota Palu adalah faktor jenis kecelakaan (X1), peran korban dalam kecelakaan (X4), jenis pelanggaran (X7) dan usia (X3) korban kecelakaan lalu lintas di Kota Palu.
Analisis Indeks Harga Saham Gabungan (IHSG) Menggunakan Metode Wavelet Thresholding
Authors: Fauziah Zahra Awaliya , Junaidi  , Handayani Lilies 
Published: January 2020

Stock is one type of long-term investment in the capital market. The stock movement indicator that is most often used in analysis by investors is the Indonesia Composite Index (ICI). ICI data is a variety of time series data, so it can be analyzed using forecasting. One forecasting method that can be used is the wavelet thresholding method. The wavelet threshold can analyze stationary, non-stationary, and nonlinear time series data by producing smooth estimates. The wavelet threshold has a wavelet filter and threshold parameters and threshold functions that can be used in analyzing. In this study MSE was assessed from several wavelet filters namely haar, daubechies, and coiflets filters at levels 1 to 7 with the thresholding function namely soft thresholding and thresholding parameters, namely minimax thresholding and sure thresholding. The data used is IHGS data in 2018 totaling 240 data. Based on the data analysis performed, MSE was obtained which means that the best filter provided in order 2 wavelet coiflet filter at level 2 and thresholding parameter is sure of thresholding with MSE value of 0.0094
Reinterpretation Of QS. al-A‘Râf [7]:11-25 On Hoax: Hermeneutics Study Of Ma’na-Cum-Maghza
Authors: Amir Abdul Muiz 
Published: January 2020

This article examines the interpretation of QS. al-Araf [7]: 11-25 by dialoguing the story of the Success of Adam and social reality. Dialogue that discusses the issue of the history of hoax, the strategy of making hoax, the impact, and handling of hoax issues. This research uses qualitative with hermeneutics ma'na-cum-maghza theory. This interpretation shows that hoax are phenomena that have existed since the beginning of human kind (Prophet Adam). The unfair contestation and an inability to accept differences caused the policy tendency. This hoax strategy is carried out through logical agreement and approving of oaths that seem right. How to handle habits can only be done through internalizing the nature of sincerity and waiting as a form of grace to accept all forms of diversity, and to cultivate a critical nature of all information received. Besides, the government also needs to take and resolve not only to provide punishment to the victims but also need to get rehabilitation to avoid prolonged depression
Mathematical and Computer Modeling of Piezoelectric Generator for Energy Harvesting Devices
Authors: Soloviev A. N. , Ermakov D. A. 
Published: January 2020

The paper deals with modeling a Piezoelectric Generator (PEG) that includes piezoactive elements, inertial mass, plate and rack. The PEG under consideration can be an element of the energy storage device in the capacity of the source of energy provided from vibrations of elements of structures and machines.The main objective of the paper is to gain the PEG efficiency by finding the optimal geometric parameters for finding the highest output potential.The elastic and piezoceramic media are modeled within the framework of the linear theory of electroelasticity. As a research tool, CAE package ACELAN is used in which three-dimensional and axisymmetric device models are built. The numerical experiments performed a modal and harmonic analysis that enabled us to identify the most effective operating frequencies.
Clinical characteristics, management and outcomes of patients with acute coronary syndrome and atrial fibrillation: real-world data from two nationwide registries in Italy
Authors: Lucà Fabiana , Caretta Giorgio , Vagnarelli Fabio , Marini Marco , Iorio Annamaria , Di Fusco Stefania Angela , Pozzi Andrea , Gabrielli Domenico , Colivicchi Furio , De Luca Leonardo , Gulizia Michele Massimo 
Published: January 2020

Background
Atrial fibrillation is common in the setting of acute coronary syndromes (ACS) although its impact on ACS remains controversial.

Aim
To describe in-hospital management of patients with atrial fibrillation and ACS evaluating the impact of atrial fibrillation on in-hospital and mid-term outcome.

Methods
We analysed the data of two prospective multicentre nationwide registries (IN-ACS Outcome and MANTRA) to assess clinical characteristics, management, and outcomes of patients with ACS and atrial fibrillation. Study outcomes included death from any cause and a composite end-point of death/re-infarction/stroke/major bleeding within index admission and 6 months’ follow-up.

Results
Out of 12 288 ACS patients, 1236 (10.1%) had atrial fibrillation at admission or developed it during hospitalization. Atrial fibrillation patients were older, more often female, and had higher burden of comorbidities. In-hospital mortality was higher among atrial fibrillation patients (8.7 vs. 2.4%, P < 0.001). Patients with atrial fibrillation had a higher incidence of re-infarction (3.5 vs. 1.7%, P < 0.0001) and ischemic stroke (1.7 vs. 0.4%, P < 0.001) compared with those in sinus rhythm. Major bleedings were also more frequent among atrial fibrillation patients (1.9 vs. 0.9%, P < 0.001). In-hospital and at 6 months’ follow-up death from any cause occurred more often in atrial fibrillation patients than in those without atrial fibrillation (9.4 vs. 3.5%, P < 0.0001). At multivariable analysis, atrial fibrillation was an independent predictor of the in-hospital composite end-point (OR 1.67, 95% CI 1.35–2.06, P < 0.0001) but not at 6 months’ follow-up. The independent role of atrial fibrillation on the in-hospital composite end-point was also confirmed by propensity score analyses.

Conclusion
Atrial fibrillation was an independent predictor for adverse in-hospital outcome in ACS. This effect disappeared at mid-term follow-up, whereas noncardiac comorbidities emerged as prognostic factors of adverse outcomes.
Assessment of right ventricular function in advanced heart failure with nonischemic dilated cardiomyopathy: insights of right ventricular elastance
Authors: Bianco Francesco , Bucciarelli Valentina , Ammirati Enrico , Occhi Lucia , Musca Francesco , Tonti Giovanni , Frigerio Maria , Gallina Sabina 
Published: January 2020

Background
The right ventriculoarterial coupling (R-V/A), a measure of right ventricular systolic dysfunction (RVSD) adaptation/maladaptation to chronic overload, and consequent pulmonary hypertension, has been little investigated in nonischemic dilated cardiomyopathy (NIDCM). We examined the correlates of R-V/A and traditional echocardiographic indices of RVSD, over the spectrum of pulmonary hypertension and tertiles of mean pulmonary artery pressures (PAPm).

Methods
In 2016–2017, we studied 81 consecutive patients for heart transplant/advanced heart failure. Inclusion criteria were NIDCM, reduced ejection fraction (≤40%) and sinus rhythm. R-V/A was computed as the RV/pulmonary elastances ratio (R-Elv/P-Ea), derived from a combined right heart catheterization/transthoracic- echocardiographic assessment [right heart catheterization/transthoracic-echocardiographic (RHC/TTE)].

Results
A total of 68 patients (mean age 64 ± 7 years, 82% men) were eligible. After adjustments, R-Elv and P-Ea were higher in isolated postcapillary-pulmonary hypertension (Ipc-PH) than combined-pulmonary hypertension (Cpc-PH) (P = 0.004 and P = 0.002, respectively), whereas R-V/A progressively decreased over Ipc-PH and Cpc-PH (P = 0.006). According to PAPm increment, P-Ea congruently increased (P-Trend = 0.028), R-Elv progressively decreased (P-Trend<0.00)1, whereas R-V/A significantly worsened (P-Trend = 0.045). At the multivariable analysis, a reduced RV longitudinal function (TAPSE<17 mm) was positively associated with R-V/A impairment (<0.8) [odds ratio 1.41, 95% confidence interval (CI) (1.07--1.87), P = 0.015]. R-Elv and P-Ea showed good interobserver reliability [interclass correlation (ICC) 0.84, 95% CI (0.32--0.99), P = 0.012 and ICC 0.98, 95% CI (0.93--99), P < 0.001, respectively].

Conclusion
Among NIDCM HF patients, in a small cohort study, RHC/TTE-derived R-V/A assessment demonstrated good correlations with pulmonary hypertension types and RV functional status. These data suggest that R-V/A encloses comprehensive information of the whole cardiopulmonary efficiency, better clarifying the amount of RVSD, with good reliability.