bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad-spectrum light pollution suppresses melatonin and increases West Nile virus–induced mortality in House Sparrows (Passer domesticus)
Authors: Kernbach Meredith E , Cassone Vincent M , Unnasch Thomas R , Martin Lynn B 
Published: March 2020

AbstractArtificial light at night (ALAN) has become a pervasive anthropogenic stressor for both humans and wildlife. Although many negative impacts of ALAN on human health have been identified, the consequences for infectious disease dynamics are largely unexplored. With the increase in popularity of energy efficient light-emitting diodes (LEDs), the effects of spectral composition of ALAN have also come into question. Previous studies showed that exposure to low levels of incandescent ALAN extended the infectious period of House Sparrows (Passer domesticus) infected with West Nile virus (WNV) without affecting mortality rates, thus increasing the pathogen initial reproductive rate (R0) by ~41%. Here, we asked whether exposure to broad-spectrum (3000 K [Kelvin; unit of color temperature]) ALAN suppressed melatonin, a hormone implicated in ALAN-induced physiological consequences, in House Sparrows. We then asked whether amber-hue bulbs (1800 K) could ameliorate the effects of WNV on individual sparrows, and whether broad-spectrum or blue-rich bulbs (3000 K and 5000 K, respectively) could exacerbate them. We found that exposure to low intensity (~5 lux) broad-spectrum (3000 K) ALAN significantly suppressed melatonin levels throughout the night. Second, we found that exposure to broad-spectrum and blue-rich (3000 + 5000 K) lights did not affect WNV viremia but did increase WNV-induced mortality. Conversely, birds exposed to amber-hue (1800 K) ALAN had lower viremia and mortality rates similar to controls (i.e. natural light conditions). This study demonstrates that ALAN affects melatonin regulation in birds, but this effect, as well as ALAN influences on infectious disease responses, can be ameliorated by particular lighting technologies.
Case report: intravascular ultrasound sonography-guided re-entry technique in crushed stent
Authors: Iannaccone Mario , Barbero Umberto , De Benedictis Michele , D’ascenzo Fabrizio 
Published: March 2020

Abstract

Background
Stent thrombosis (ST) is a rare, but potentially fatal complication. Procedural problems, such as stent under-dimension/under-expansion or dual antiplatelet drug resistance may result into ST. These conditions are more frequent during primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI).

Case summary
A 60-year-old male patient presented to our hospital with an inferior STEMI. In the emergency department, a dual antiplatelet therapy was administered with ticagrelor 180 mg and aspirin 250 mg IV. During the observation, the patient experienced a ventricular fibrillation. Urgent coronary angiography showed an occlusion of the proximal right coronary artery. Thrombus aspiration was performed followed by implantation of one drug-eluting stent. After 45 min early ST occurred and was treated by immediate thrombus aspiration and post-dilatation. Intravascular ultrasound sonography (IVUS) showed severe strut malapposition due to a partial crush after post-dilatation. Since it was not possible to directly insert the first guidewire in the stent lumen, the IVUS probe was placed between the vessel wall and the crushed stent to guide the manoeuvre.

Discussion
Crushed stent is a rare complication, being caused by an incorrect passage of the guidewire between the stent’s struts and the vessel wall in case of severe underexpansion. In this case, an IVUS-guided re-entry could be an option to gain the stent true lumen and avoid a second stent implantation.
Risk prediction models for out-of-hospital cardiac arrest outcomes in England
Authors: Ji Chen , Brown Terry P , Booth Scott J , Hawkes Claire , Nolan Jerry P , Mapstone James , Fothergill Rachael T , Spaight Robert , Black Sarah , Perkins Gavin D ,   OHCAO Collaborators, Foster Theresa , Mersom Frank , Francis Gurkamal , O’Rourke Michelle , Bradley Clare , King Philip , Bucher Patricia , Lynde Jessica , Lumley-Holmes Jenny , Mark Julian 
Published: March 2020

Abstract

Aims
The out-of-hospital cardiac arrest (OHCA) outcomes project is a national research registry. One of its aims is to explore sources of variation in OHCA survival outcomes. This study reports the development and validation of risk prediction models for return of spontaneous circulation (ROSC) at hospital handover and survival to hospital discharge.

Methods and results
The study included OHCA patients who were treated during 2014 and 2015 by emergency medical services (EMS) from seven English National Health Service ambulance services. The 2014 data were used to identify important variables and to develop the risk prediction models, which were validated using the 2015 data. Model prediction was measured by area under the curve (AUC), Hosmer–Lemeshow test, Cox calibration regression, and Brier score. All analyses were conducted using mixed-effects logistic regression models. Important factors included age, gender, witness/bystander cardiopulmonary resuscitation (CPR) combined, aetiology, and initial rhythm. Interaction effects between witness/bystander CPR with gender, aetiology and initial rhythm and between aetiology and initial rhythm were significant in both models. The survival model achieved better discrimination and overall accuracy compared with the ROSC model (AUC = 0.86 vs. 0.67, Brier score = 0.072 vs. 0.194, respectively). Calibration tests showed over- and under-estimation for the ROSC and survival models, respectively. A sensitivity analysis individually assessing Index of Multiple Deprivation scores and location in the final models substantially improved overall accuracy with inconsistent impact on discrimination.

Conclusion
Our risk prediction models identified and quantified important pre-EMS intervention factors determining survival outcomes in England. The survival model had excellent discrimination.
Simple electrocardiographic measures improve sudden arrhythmic death prediction in coronary disease
Authors: Chatterjee Neal A , Tikkanen Jani T , Panicker Gopi K , Narula Dhiraj , Lee Daniel C , Kentta Tuomas , Junttila Juhani M , Cook Nancy R , Kadish Alan , Goldberger Jeffrey J , Huikuri Heikki V , Albert Christine M ,   for the PREDETERMINE Investigators
Published: March 2020

Abstract

Aims
To determine whether the combination of standard electrocardiographic (ECG) markers reflecting domains of arrhythmic risk improves sudden and/or arrhythmic death (SAD) risk stratification in patients with coronary heart disease (CHD).

Methods and results
The association between ECG markers and SAD was examined in a derivation cohort (PREDETERMINE; N = 5462) with adjustment for clinical risk factors, left ventricular ejection fraction (LVEF), and competing risk. Competing outcome models assessed the differential association of ECG markers with SAD and competing mortality. The predictive value of a derived ECG score was then validated (ARTEMIS; N = 1900). In the derivation cohort, the 5-year cumulative incidence of SAD was 1.5% [95% confidence interval (CI) 1.1–1.9] and 6.2% (95% CI 4.5–8.3) in those with a low- and high-risk ECG score, respectively (P for Δ &lt; 0.001). A high-risk ECG score was more strongly associated with SAD than non-SAD mortality (adjusted hazard ratios = 2.87 vs. 1.38 respectively; P for Δ = 0.003) and the proportion of deaths due to SAD was greater in the high vs. low risk groups (24.9% vs. 16.5%, P for Δ = 0.03). Similar findings were observed in the validation cohort. The addition of ECG markers to a clinical risk factor model inclusive of LVEF improved indices of discrimination and reclassification in both derivation and validation cohorts, including correct reclassification of 28% of patients in the validation cohort [net reclassification improvement 28 (7–49%), P = 0.009].

Conclusion
For patients with CHD, an externally validated ECG score enriched for both absolute and proportional SAD risk and significantly improved risk stratification compared to standard clinical risk factors including LVEF.

Clinical Trial Registration
https://clinicaltrials.gov/ct2/show/NCT01114269. ClinicalTrials.gov ID NCT01114269.
Hypertensive coronary microvascular dysfunction: a subclinical marker of end organ damage and heart failure
Authors: Zhou Wunan , Brown Jenifer M , Bajaj Navkaranbir S , Chandra Alvin , Divakaran Sanjay , Weber Brittany , Bibbo Courtney F , Hainer Jon , Taqueti Viviany R , Dorbala Sharmila , Blankstein Ron , Adler Dale , O’Gara Patrick , Di Carli Marcelo F 
Published: March 2020

Abstract

Aims
Hypertension is a well-established heart failure (HF) risk factor, especially in the context of adverse left ventricular (LV) remodelling. We aimed to use myocardial flow reserve (MFR) and global longitudinal strain (GLS), markers of subclinical microvascular and myocardial dysfunction, to refine hypertensive HF risk assessment.

Methods and results
Consecutive patients undergoing symptom-prompted stress cardiac positron emission tomography (PET)-computed tomography and transthoracic echocardiogram within 90 days without reduced left ventricular ejection fraction (&lt;40%) or flow-limiting coronary artery disease (summed stress score ≥ 3) were included. Global MFR was quantified by PET, and echocardiograms were retrospectively analysed for cardiac structure and function. Patients were followed over a median 8.75 (Q1–3 4.56–10.04) years for HF hospitalization and a composite of death, HF hospitalization, MI, or stroke. Of 194 patients, 155 had adaptive LV remodelling while 39 had maladaptive remodelling, which was associated with lower MFR and impaired GLS. Across the remodelling spectrum, diastolic parameters, GLS, and N-terminal pro-B-type natriuretic peptide were independently associated with MFR. Maladaptive LV remodelling was associated with increased adjusted incidence of HF hospitalization and death. Importantly, the combination of abnormal MFR and GLS was associated with a higher rate of HF hospitalization compared to normal MFR and GLS [adjusted hazard ratio (HR) 3.21, 95% confidence interval (CI) 1.09–9.45, P = 0.034), including in the adaptive remodelling subset (adjusted HR 3.93, 95% CI 1.14–13.56, P = 0.030).

Conclusion
We have demonstrated important associations between coronary microvascular dysfunction and myocardial mechanics that refine disease characterization and HF risk assessment of patients with hypertension based on subclinical target organ injury.
Functional tricuspid regurgitation of degenerative mitral valve disease: a crucial determinant of survival
Authors: Essayagh Benjamin , Antoine Clémence , Benfari Giovanni , Maalouf Joseph , Michelena Hector I , Crestanello Juan A , Thapa Prabin , Avierinos Jean-François , Enriquez-Sarano Maurice 
Published: March 2020

Abstract

Aims
To assess functional tricuspid regurgitation (FTR) determinants, consequences, and independent impact on outcome in degenerative mitral regurgitation (DMR).

Methods and results
All patients diagnosed with isolated DMR 2003–2011, with structurally normal tricuspid leaflets, prospective FTR grading and systolic pulmonary artery pressure (sPAP) estimation by Doppler echocardiography at diagnosis were identified and long-term outcome analysed. The 5083 DMR eligible patients [63 ± 16 years, 47% female, ejection fraction (EF) 63 ± 7%, and sPAP 35 ± 13 mmHg] presented with FTR graded trivial in 45%, mild in 37%, moderate in 15%, and severe in 3%. While pulmonary hypertension (PHTN-sPAP ≥ 50 mmHg) was the most powerful FTR severity determinant, other strong FTR determinants were older age, female sex, lower left ventricle EF, DMR, and particularly atrial fibrillation (AFib) (all P ≤ 0.002). Functional tricuspid regurgitation moderate/severe was independently linked to more severe clinical presentation, more oedema, lower stroke volume, and impaired renal function (P ≤ 0.01). Survival (95% confidence interval) throughout follow-up [70% (69–72%) at 10 years] was strongly associated with FTR severity [82% (80–84%) for trivial, 69% (66–71%) for mild, 51% (47–57%) for moderate, and 26% (19–35%) for severe, P &lt; 0.0001]. Excess mortality persisted after comprehensive adjustment [adjusted hazard ratio 1.40 (1.18–1.67) for moderate FTR and 2.10 (1.63–2.70) for severe FTR, P ≤ 0.01]. Excess mortality persisted adjusting for sPAP/right ventricular function (P &lt; 0.0001), by matching [adjusted hazard ratios 2.08 (1.50–2.89), P &lt; 0.0001] and vs. expected survival [risk ratio 1.79 (1.48–2.16), P &lt; 0.0001]. Within 5-year of diagnosis valve surgery was performed in 73% (70–75%) and 15% (13–17%) of severe and moderate DMR and in only 26% (19–34%) and 6% (4–8%) of severe and moderate FTR. Valvular surgery improved outcome without alleviating completely higher mortality associated with FTR (P &lt; 0.0001).

Conclusion
In this large DMR cohort, FTR was frequent and causally, not only linked to PHTN but also to other factors, particularly AFib. Higher FTR severity is associated at diagnosis with more severe clinical presentation. Long term, FTR is independently of all confounders, associated with considerably worse mortality. Functional tricuspid regurgitation moderate and even severe is profoundly undertreated. Thus careful assessment, consideration for tricuspid surgery, and testing of new transcatheter therapy is warranted.
Genetic predisposition to smoking in relation to 14 cardiovascular diseases
Authors: Larsson Susanna C , Mason Amy M , Bäck Magnus , Klarin Derek , Damrauer Scott M ,   Million Veteran Program, Michaëlsson Karl , Burgess Stephen 
Published: March 2020

Abstract

Aims
The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs).

Methods and results
Our primary genetic instrument comprised 361 single-nucleotide polymorphisms (SNPs) associated with smoking initiation (ever smoked regularly) at genome-wide significance. Data on the associations between the SNPs and 14 CVDs were obtained from the UK Biobank study (N = 367 643 individuals), CARDIoGRAMplusC4D consortium (N = 184 305 individuals), Atrial Fibrillation Consortium (2017 dataset; N = 154 432 individuals), and Million Veteran Program (MVP; N = 190 266 individuals). The main analyses were conducted using the random-effects inverse-variance weighted method and complemented with multivariable MR analyses and the weighted median and MR-Egger approaches. Genetic predisposition to smoking initiation was most strongly and consistently associated with higher odds of coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension. Genetic predisposition to smoking initiation was additionally associated with higher odds of deep vein thrombosis and pulmonary embolism in the UK Biobank but not with venous thromboembolism in the MVP. There was limited evidence of causal associations of smoking initiation with atrial fibrillation, aortic valve stenosis, thoracic aortic aneurysm, and intracerebral and subarachnoid haemorrhage.

Conclusion
This MR study supports a causal association between smoking and a broad range of CVDs, in particular, coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension.
Differences in housing transitions and changes in health and self-determination between formerly homeless individuals
Authors: van der Laan Jorien , Boersma Sandra N , al Shamma Sara , Akkermans Reinier , van Straaten Barbara , Rodenburg Gerda , van de Mheen Dike , Wolf Judith R L M 
Published: March 2020

Abstract

Background
To reduce homelessness, it is important to gain a better understanding of the differences between homeless people who remain in institutions and those who gain and can sustain independent housing. This longitudinal study explores differences in housing transitions and differences in changes in health and self-determination between formerly homeless people still living in institutions 2.5 years later and those now living in independent housing in the Netherlands.

Methods
This study mapped the housing transitions of 263 participants from when they entered the social relief system (SRS) to 2.5 years later when they were in independent housing or institutions. These individuals were compared at the 2.5-year mark in terms of gender, age and retrospectively in terms of duration of homelessness. They were also compared with regard to changes in psychological distress, perceived health, substance use and self-determination.

Results
Two and a half years after entering the SRS, 81% of participants were independently housed and 19% still lived in institutions. People in institutions had a longer lifetime duration of homelessness, were more often men, and their number of days of alcohol use had decreased significantly more, whereas independently housed people had shown a significant increase in their sense of autonomy and relatedness.

Conclusion
Formerly homeless people living in independent housing and in institutions show few health-related differences 2.5 years after entering the SRS, but changes in autonomy and relatedness are distinctly more prevalent, after the same period of time, in those who are independently housed.
New ECCO model documents for Material Deposit and Transfer Agreements in compliance with the Nagoya Protocol
Authors: Verkley Gerard , Perrone Giancarlo , Piña Mery , Scholz Amber Hartman , Overmann Jörg , Zuzuarregui Aurora , Perugini Iolanda , Turchetti Benedetta , Hendrickx Marijke , Stacey Glyn , Law Samantha , Russell Julie , Smith David , Lima Nelson 
Published: March 2020

ABSTRACT
The European Culture Collections’ Organisation presents two new model documents for Material Deposit Agreement (MDA) and Material Transfer Agreement (MTA) designed to enable microbial culture collection leaders to draft appropriate agreement documents for, respectively, deposit and supply of materials from a public collection. These tools provide guidance to collections seeking to draft an MDA and MTA, and are available in open access to be used, modified, and shared. The MDA model consists of a set of core fields typically included in a ‘deposit form’ to collect relevant information to facilitate assessment of the status of the material under access and benefit sharing (ABS) legislation. It also includes a set of exemplary clauses to be included in ‘terms and conditions of use’ for culture collection management and third parties. The MTA model addresses key issues including intellectual property rights, quality, safety, security and traceability. Reference is made to other important tools such as best practices and code of conduct related to ABS issues. Besides public collections, the MDA and MTA model documents can also be useful for individual researchers and microbial laboratories that collect or receive microbial cultures, keep a working collection, and wish to share their material with others.
Gendering South Africa's Foreign Policy: Toward a Feminist Approach?
Authors: Haastrup Toni 
Published: March 2020

Abstract
South Africa's leadership has sought ethical foreign policy since the advent of democracy. This foreign policy outlook focuses on the African continent and includes certain articulations of pro-gender justice norms. In this article, I reflect on the extent to which South Africa's foreign policy embraces these norms as part of its foreign apparatus and practices. It takes at its starting point the nascent literature on feminist foreign policy applied to South Africa, which shares similarities to countries in the Global North that claim a feminist orientation to foreign policy. Moreover, it takes account of gender dynamics at the domestic level and how they are manifested in foreign policy discourses and practices, particularly in the understanding and implementation of the Women, Peace, and Security agenda. Utilizing qualitative content analysis, this article provides context and meaning for how gender concerns have evolved in South Africa's foreign policy, including the role of certain norm entrepreneurs in shaping the gender narrative. The article concludes that the domestic context is important to shaping and limiting how a country can enact feminist foreign policy. Importantly, the South African case provides a Global South dimension to the nascent scholarship.
Intervention Characteristics Associated With a Reduction in Fear of Falling Among Community-Dwelling Older People: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Kruisbrink Marlot , Delbaere Kim , Kempen Gertrudis I J M , Crutzen Rik , Ambergen Ton , Cheung Kei-Long , Kendrick Denise , Iliffe Steve , Zijlstra G A Rixt 
Published: March 2020

Abstract

Background and Objectives
Fear of falling (FoF) is associated with decreased physical functioning and an increased fall risk. Interventions generally demonstrate moderate effects and optimized interventions are needed. Intervention characteristics, such as setting or delivery method may vary. We investigated which overarching intervention characteristics are associated with a reduction in FoF in community-dwelling older people.

Research Design and Methods
A systematic review and meta-analysis of randomized controlled trials (RCTs) in community-dwelling older people without specific diseases was performed. Associations between intervention characteristics and standardized mean differences (SMD) were determined by univariate meta-regression. Sensitivity analyses were performed.

Results
Data on 62 RCTs were extracted, 50 intervention groups were included in the meta-analysis. Most intervention characteristics and intervention types were not associated with the intervention effect. Supervision by a tai chi instructor (SMD: −1.047, 95% confidence interval [CI]: −1.598; −0.496) and delivery in a community setting (SMD: −0.528, 95% CI: −0.894; −0.161) were—compared to interventions without these characteristics—associated with a greater reduction in FoF. Holistic exercise, such as Pilates or yoga (SMD: −0.823, 95% CI: −1.255; −0.392), was also associated with a greater reduction in FoF. Delivery at home (SMD: 0.384, 95% CI: 0.002; 0.766) or with written materials (SMD: 0.452, 95% CI: 0.088; 0.815) and tailoring were less effective in reducing FoF (SMD: 0.687, 95% CI: 0.364; 1.011).

Discussion and Implications
Holistic exercise, delivery with written materials, the setting and tailoring potentially represent characteristics to take into account when designing and improving interventions for FoF in community-dwelling older people. PROSPERO international prospective register of systematic reviews, registration ID CRD42018080483.
Aging in New Zealand: Ka haere ki te ao pakeketanga
Authors: Parr-Brownlie Louise C , Waters Debra L , Neville Stephen , Neha Tia , Muramatsu Naoko 
Published: March 2020

AbstractAotearoa-New Zealand is expecting the number of older adults to double in the next 20 years. Despite publicly funded health and welfare support for older citizens, the aging experience differs across ethnic groups. This creates opportunities and challenges for health and social services to deliver culturally safe and equitable care for all older New Zealanders. Longitudinal and large data sets are pivotal for characterizing the aging experience from birth to advanced age. The New Zealand research funding system responded to predicted demographic changes by increasing funding in order to inform and address key health and well-being issues for older people. In addition, government strategies and policies increasingly focus on social aspects of aging and health inequities and require researchers and organizations to be better connected to end-users. New Zealand needs to continue to fund research that identifies unique and courageous service delivery solutions that result in positive social, financial, psychological, and physical aging for older New Zealanders.