bluuebunny/crossref_metadata_2025_split huggingface dataset:
P5718Effects of the fluoroquinolones moxifloxacin and levofloxacin on the QT subintervals: sex differences in ventricular repolarization
Authors: Taubel J , Prasad K , Rosano G , Van Langenhoven L , Fernandes S , Sugiyama A 
Published: October 2019

Abstract

Background
The effects of medicines affecting cardiac repolarization can be further evaluated by assessing the balance of inward and outward currents. These can be detected in the ECG by analysing the QT subintervals. Pure hERG potassium channel block was shown to prolong both early repolarization (J-Tpeak) and late repolarization (Tpeak-Tend), whereas multichannel blockers may shorten or have no effect on J-Tpeak.
The gender dependency of ventricular repolarization is also well known. Recently, Matsukura indicated that moxifloxacin significantly increased J-Tpeak and Tpeak-Tend and females in their study were more sensitive than males to the drug-induced J-Tpeak prolongation and QTcF.

Purpose
The purpose of the present study is to use data from two Thorough QT (TQT) studies to characterize the differences in depolarization (QRS), early repolarization (J-Tpeak), and late repolarization (Tpeak-Tend) between moxifloxacin and levofloxacin and further define the sex differences in QTc and subintervals.

Methods
Data from two TQT studies were used to further investigate the impact of moxifloxacin (400 mg) and levofloxacin (1000 and 1500 mg) on QT subintervals using validated algorithms for measurement of QRS, J-Tpeak and Tpeak–Tend intervals. Concentration-effect analyses were performed to establish a potential relationship between the ECG effects and the concentrations of the two fluoroquinolones as typically males and females also show differences in plasma concentrations due to differences in body weight.

Results
The relationships between moxifloxacin and levofloxacin plasma concentrations and their respective predicted ΔΔQTcF, ΔΔQRS, ΔΔJ-Tpeakc and ΔΔTpeak-Tend values are shown in Fig 1.
The plasma concentrations were higher for females than males in both drugs.
Moxifloxacin was shown to be a more potent prolonger of QTcF and had a pronounced effect on J-Tpeakc, consistent with its effects on both IKr and IKs channels while levofloxacin had little effect on J-Tpeakc. For moxifloxacin, the concentration-effect modelling showed a greater effect for females on QTcF and J-Tpeakc while for levofloxacin the inverse was true. Based on the assumption that repolarization reserve of females relies to a greater extent on IKs channels it would be reasonable to assume that they are more affected by a medicine that blocks IKs in addition to IKr.
Figure 1

Conclusions
This study showed that levofloxacin elicited a smaller ΔΔQTcF and ΔΔJ-Tpeakc prolongation when compared to moxifloxacin. The results of this study also showed a different pattern of sex difference in repolarization after administration of both drugs. which may suggest a difference in expression of IKs and possibly IKr channels.
P5728Association of systolic blood pressure and cardiovascular outcomes at different age groups in the healthy general population: a nationwide prospective cohort study
Authors: Jung M H , Ihm S H , An S J , Yi S W 
Published: October 2019

Abstract

Background
Uncertainties remain regarding the effect of blood pressure on various cardiovascular outcomes in different age groups.

Purpose
We aimed to identify 1) whether a systolic blood pressure (SBP) of 130–139 mm Hg elevates cardiovascular disease (CVD) mortality and 2) whether SBP shows a linear association with cause-specific CVD mortality in all age groups among individuals without known hypertension and CVD.

Methods
We used the Korean National Health Insurance sample data (n=429,220). Participants were categorized into three groups by age (40–59, 60–69, and 70–80 years).

Results
A positive and graded association was generally observed between SBP and overall and cause-specific CVD mortality regardless of age, except for ischemic heart disease (IHD) mortality in those aged 70–80 years. Among those aged 70–80, the hazard ratios (HRs) (95% CIs) for overall CVD mortality were 1.08 (0.92–1.28), 1.14 (0.97–1.34), and 1.34 (1.14–1.58) for SBP values of 120–129, 130–139, and 140–149 mm Hg, respectively, compared to SBP <120 mm Hg. For total stroke mortality, the corresponding HRs were 1.29 (1.02–1.64), 1.37 (1.09–1.72), and 1.52 (1.20–1.93), while for IHD mortality, the corresponding HRs were 0.90 (0.64–1.26), 0.86 (0.62–1.19), and 1.29 (0.93–1.78). Nonlinear associations were significant for IHD (Fig 1).
Figure 1

Conclusion
In the elderly Korean population, SBPs of 130–139 mm Hg elevated total stroke mortality, but not IHD mortality, compared to normal BP, and a linear association was not observed for IHD mortality in the range <140 mm Hg. Regarding an appropriate diagnostic cutoff for hypertension, an individualized approach considering each person's organ susceptibility is needed for the elderly population.

Acknowledgement/Funding
None
P5730Do hypertensive women with coronary artery disease benefit from lowering systolic blood pressure under 130 mmHg? Long-term mortality in the INternational VErapamil SR-trandolapril STudy (INVEST)
Authors: Sava R I , Chen Y , Taha Y K , Gong Y , Smith S M , Cooper-Dehoff R , Keeley E C , Pepine C J , Handberg E M 
Published: October 2019

Abstract

Background
Hypertension (HTN) and coronary artery disease (CAD) are a prevalent combination in women, however limited data are available to guide blood pressure (BP) management. We hypothesize older women with HTN and CAD may not derive the same prognostic benefit from systolic BP (SBP) lowering <130 mmHg.

Purpose
To investigate the long-term mortality implications of different achieved SBP levels in hypertensive women with CAD.

Methods
Long-term, all-cause mortality data were analyzed for 9216 women, stratified by risk attributable to clinical severity of CAD (women with prior myocardial infarction or revascularization considered at high, all others at low risk) and by age (50 - <65 or ≥65 yo). The prognostic impact of achieving mean in-trial SBP <130 (referent group) was compared with 130 to <140 and ≥140 mmHg using Cox proportional hazards, adjusting for demographic and clinical characteristics.

Results
During 108,838 person-years of follow-up, 2945 deaths occurred. High risk women (n=3011) had increased long-term mortality in comparison to low risk women (n=6205) (adjusted HR 1.38, CI 1.28–1.5, p<0.001). Within risk groups, crude mortality percentages decreased according to BP values (table). As expected, high risk women were more likely to be ≥65 yo (68.68% vs. 50.51%, p<0.0001) or have SBP ≥140 mmHg (43.08% vs. 31.18%, p<0.0001). In adjusted analyses, an SBP ≥140 mmHg was associated with worse outcomes than SBP <130 mmHg in the entire cohort (HR 1.3, CI 1.2–1.5, p<0.0001) and when stratifying by risk (low risk group, HR = 1.47, CI 1.28–1.7, p<0.0001; high risk group, HR = 1.71, CI 1.01–1.35, p=0.03). In analyses stratified by age and risk, women ≥65 years and at high risk had decreased mortality in the 130 - <140 SBP category vs. <130 mmHg (HR 0.812, 95% CI 0.689–0.957, p=0.0133; figure).
Women and deaths by risk and SBP group Group SBP category Women (n) Mortality (n) Mortality (%) High risk <130 773 338 44 130–<140 941 414 44 ≥140 1297 694 54 Low risk <130 2187 390 18 130–<140 2083 451 22 ≥140 1935 658 34 SBP = systolic blood pressure; n = number; % = percent per each group.
Mortality adjusted HRs

Conclusion
In women ≥65 yo with hypertension and prior myocardial infarction and/or coronary revascularization enrolled in INVEST, a SBP between 130 to <140 mmHg was associated with lower all-cause, long-term mortality versus SBP <130 mmHg.

Acknowledgement/Funding
The main INVEST (International Verapamil [SR]/Trandolapril Study) was funded by grants from BASF Pharma, Ludwigshafen, Germany; Abbott Laboratories, A
P5733IABP use in patients with STEMI complicated by cardiogenic shock: time for rehabilitation?
Authors: Somaschini A , Cornara S , Demarchi A , Mandurino Mirizzi A , Puccio S , Galazzi M , Camporotondo R , Crmi M , Ferlini M , Gnecchi M , Oltrona Visconti L , De Servi S , De Ferrari G M 
Published: October 2019

Abstract

Background
Evidence from a large randomized clinical trial has led international guidelines to downgrade to Class III the recommendation level for the routine use of intra-aortic balloon pump (IABP) in patients with STEMI complicated by cardiogenic shock (CS). Despite this, its use in clinical practice remains high.

Purpose
The aim of our study was to evaluate whether IABP use could provide a prognostic benefit in a large real-world population of STEMI patients undergoing primary PCI (pPCI).

Methods
Our registry included 2958 consecutive patients undergoing primary pPCI for STEMI in our department from 2005 to 2017. The presence of a persistent (>30 min) systolic blood pressure <90 mmHg and signs of pulmonary congestion or impaired end organ perfusion needing catecholamine infusion qualified for CS. Among patients with CS we compared mortality between those with and those without IABP in the whole population and in the pre-specified subgroup with anterior STEMI. Univariate (cross-tables and Kaplan-Meier curves with log-rank test) and multivariate mortality analysis (Cox regressions) were performed.

Results
CS occurred in 246 patients (8.3%); among these patients, 145 (60%) had anterior AMI. Mortality at 30 days was 3.7 in inferior vs 7.1% in anterior STEMI (p<0.001). In these two groups of patients, IABP was used in 32% and 66.7% of cases, respectively. In the whole CS group, IABP use was associated with a lower 30-day mortality (39% vs 53%, p=0.020 – see figure panel A); this figure was confirmed at multivariable analysis (HR 0.49, 95% CI 0.27–0.87, p=0.016) after adjusting for age, CK peak, triple-vessel disease, eGFR and all-TIMI bleeding during hospital stay. IABP use in CS patients was not associated with major complications or an increased rate of Hb drop (>3 mg/dL) during hospital stay. In the subgroup of patients with anterior STEMI, there was a marked survival benefit at univariate analysis (30-day mortality 41% vs 61%, p=0.013 – see figure panel B), confirmed at multivariable analysis (HR 0.40, 95% CI 0.19–0.88, p=0.023) after adjusting for the same variables of the previous model. In the subgroup of patients with inferior STEMI, IABP use was not significantly associated with a lower 30-day mortality (32% vs 41%, p=0.380).
Figure 1

Conclusion
In the present large real-world cohort of unselected patients with STEMI, the use of IABP in case of CS was found to improve survival. This finding suggests that IABP could still play a role in patient with STEMI complicated by CS, especially when additional risk features are present, such as anterior MI. We suggest that additional careful prospective studies are needed before abandoning or markedly limiting the use of IABP in this clinical setting.
P5736Mortality in infarct-related cardiogenic shock patients treated with an microaxial pump: influence of timing and predicted risk
Authors: Schaefer A , Werner N , Westenfeld R , Moller J E 
Published: October 2019

Abstract

Background
In-hospital mortality in acute myocardial infarction-related cardiogenic shock (AMI-CS) remains high at ∼40%. No prospective trials have been finished investigating the influence of mechanical support in AMI-CS. We compared observed to individually predicted mortality using CardShock-, Shock II-, and SAVE-scores in AMI-CS patients treated between 2013 and 2017 with an Impella microaxial pump, who met the IABP-Shock II-trials inclusion/exclusion criteria in order to determine whether standardised use of an Impella microaxial flow-pump in AMI-CS is associated with lower than predicted mortality rates and whether timing of implantation or selecting patients based on predicted risk is meaningful.

Methods
We analyzed data from 166 consecutive AMI-CS patients meeting the inclusion/exclusion criteria of the IABP-Shock II-trial (age 65±12 years), who received an Impella microaxial pump and compared observed vs. individually predicted mortality using CardShock-, Shock II-, and SAVE-scores. 39% (n=65) had been resuscitated before Impella implantation.

Results
Overall 30-day mortality was 43%. Mortality was higher in resuscitated patients (50% vs. 36%, p=0.0324) and when Impella was implanted post-PCI (Impella-pre-PCI: 29%, Impella-post-PCI: 50%, p=0.0130). In all score systems predicted mortality was significantly higher than observed mortality on Impella support for individuals with highest predicted risk (IABP-Shock II predicted 77% vs observed 44%, p=0.010; CardShock predicted 77% vs observed 51%, p=0.017; SAVE predicted 81% vs observed 56%, p<0.001).

Conclusion
In the absence of prospective trials, our retrospective analysis encourages the use of active mechanical circulatory support by Impella microaxial pumps in high-risk patients with AMI-CS and supports the concept of early implantation prior to PCI.
P5742Prognostic model of the development of the first atherothrombotic stroke
Authors: Shishkova V , Stakhovskaya L , Adasheva T V , Remennic A , Valyaeva V 
Published: October 2019

Abstract

Aim
The study of the relationship between various parameters: clinical-anthropometric, biochemical, metabolic, vascular-inflammatory, molecular-genetic and the development of the first ischemic stroke, and the development of a prognostic model for determining the probability of its occurrence.

Material and methods
196 patients who underwent the first ischemic stroke and 119 people who did not suffer a stroke, corresponding to age, place of residence and nationality to a group of patients, were examined. The main anthropometric, clinical, biochemical and metabolic parameters were assessed; markers of vascular inflammation and endothelial dysfunction. Genotyping of single nucleotide polymorphisms of genes: IL8, ADIPOQ, ADIROR, APOB, APOC-IV, BDNF, GRM3 using ready-made TaqMan probes was carried out.

Results
Based on the results of the correlation analysis, the following parameters were statistically significant with the first ischemic stroke: weight, BMI, WC, homocysteine, insulin, adiponectin, cystatin C, ApoA1, Apo B, OHL, XC-HDL, LDL, TG, CRB-sh, glucose, uric acid, IL-1b, IL-4, IL-6, IL-8, TNF-a, VEGF-A. The binary logistic regression method was used to construct the forecast model. The final independent model includes the following independent variables: weight, diabetes, adiponectin, Apo A1, IL-1b, IL-4, ADIPOQ (rs17366743), GRM3 (rs2228595), R2 value of Nagelkerk was 0.839. The percentage of agreement between the model and the “training sample” was 90.7%. The percentage of consent of the model with the “independent sample” was 87.1%, the overall percentage of the model's agreement for all patients was 89.8%. In accordance with the received data, the ROC-curve (Receiver Operating Characteristic) was constructed, the area under the ROC-curve was 0.92.

Conclusion
Based on the data obtained in this study, a probability model for the development of the first ischemic stroke was obtained. Of all the parameters studied in the study, the largest contribution to the probability of development of the first ischemic stroke, according to the model obtained, is made by the parameters: diabetes, adiponectin, Apo A1, IL-4.

Acknowledgement/Funding
None
P5743Overweight and obesity in adolescent men in Sweden and risk of early stroke
Authors: Rosengren A , Robertson J , Schaufelberger M , Aberg D , Schioler L , Aberg M 
Published: October 2019

Abstract

Background
Increasing numbers of stroke cases in the young are reported in many countries, potentially at least partly due to rising rates of overweight and obesity. Most data on the effect of obesity on stroke is derived from middle aged populations; there is a comparative lack of information on the effect of excessive body weight in young people.

Purpose
We aimed to determine whether body mass index (BMI) at age 18 predicted early stroke events among men in Sweden.

Methods
Population-based Swedish cohort study of conscripts (n=1,668,921; mean age at baseline, 18.3 years) who enlisted during 1968–2005. Follow-up was done through linkage to the nationwide Swedish patient and death registries. Risk of a first hospitalization for stroke (any type) during follow-up (5–46 years) was calculated with Cox proportional hazards models. Objective baseline measures of fitness and cognition were included in the models in a second set of analyses.

Results
During follow-up there were 12,512 first hospitalizations for stroke (mean age at diagnosis, 48.5 (SD 9.4) years, maximum 64 years). Compared with men with BMI of 18.5 to 20.0 kg/m2, men with BMI 20 to <22.5 and 22.5 to <25.0 kg/m2 had hazard ratios (HR) of 1.06 (1.00–1.12) and 1.23 (1.14–1.31), respectively, for hospitalization for stroke, after adjustment for age, year of conscription, comorbidities at baseline, parental education, blood pressure, IQ, muscle strength, and fitness. Those with a BMI of ≥35 kg/m2 had an HR of 3.33 (2.46–4.51) for an event before the age of 65, compared to slim men. The multiple-adjusted risk per 1-unit increase in BMI was 1.07 (95% CI, 1.06–1.08).

Conclusion
We found a rise in risk of early hospitalisation for stroke detectable already at normal levels of body weight at age 18, and rising to more than 3-fold in the highest weight category. Given increasing levels of body weight, and prevalence of overweight, obesity, and severe obesity in young adults, the increased incidence of stroke in the young may potentially partly be explained by rising body weight, with an obvious potential for prevention.
P5744Sleep-disordered breathing assessed by holter-monitoring is associated to worsened one-year clinical outcomes in ischemic stroke patients: a cardiopulmonary coupling analysis
Authors: Kang D O , Kim C K , Park Y , Jang W Y , Kim W , Choi J Y , Choi C U , Na J O 
Published: October 2019

Abstract

Background
Sleep-disorder breathing (SDB) using polysomnography is closely associated to poor functional and clinical outcomes in ischemic stroke patients. The cardiopulmonary coupling analysis using Holter-monitoring (CPC-Holter analysis) is an emerging feasible modality to investigate SDB.

Purpose
We investigated the association between SDB defined by CPC-Holter analysis and one-year clinical outcome in patients with acute ischemic stroke.

Methods
Total 666 patients with acute ischemic stroke who underwent Holter-monitoring were enrolled. The CPC-Holter analysis was conducted and SDB was defined as the presence of narrow-band (NB) coupling during sleep time. Primary outcome was recurrent ischemic stroke, and secondary outcome was major adverse cerebrovascular event (MACE), a composite of recurrent ischemic stroke, transient ischemic attack, and all-cause mortality within one year since discharge.

Result
The NB coupling was present in 205 (30.8%) of 666 patients with mean age of 64.1±12.8 years. The NB group showed significantly higher incidence of both recurrent ischemic stroke (8.3% vs. 1.4%, p<0.001) and MACE (14.9% vs. 3.0%, p<0.001) within one-year. In multivariate analysis, presence of NB coupling remained as an independent predictor of both recurrent ischemic stroke and MACE (HR: 4.81; 95% CI: 1.73–13.4; p=0.003; and HR 4.17; 95% CI: 1.74–10.0; p<0.001, respectively). The results were consistent after propensity-score matched analysis with 164 patient pairs (C-statistics=0.757).
One-year clinical outcomes Overall population (n=666) PSM population (n=328) no NB (=461) NB (n=205) Log-rank p-value OR (95% CI) no NB (n=164) NB (n=164) Log-rank p-value OR (95% CI) Recurrent ischemic stroke 6 (1.4) 14 (8.3) <0.001 5.73 (2.20–14.9) 3 (2.0) 11 (8.1) 0.026 3.85 (1.07–13.8) Transient ischemic attack 3 (0.7) 3 (1.7) 0.275 2 (1.3) 3 (2.1) 0.633 Hemorrhagic stroke 0 (0.0) 2 (1.2) 0.027 0 (0.0) 2 (1.5) 0.148 Total death 3 (0.7) 9 (4.8) 0.001 2 (1.3) 3 (1.9) 0.641 MACEs 12 (3.0) 25 (14.9) <0.001 4.63 (2.06–10.4) 7 (5.2) 17 (13.1) 0.030 2.95 (1.06–8.21) Data are expressed as n (%). CI = confidence interval; MACE = major adverse cardiovascular event; NB = narrow-band; OR = odds ratio.
One-year clinical outcomes

Conclusion
SDB assessed by CPC-Holter analysis at early phase of ischemic stroke is a powerful prognostic marker for predicting one-year adverse clinical outcomes. The CPC analysis using Holter-monitoring is a useful modality and could be easily applied to predict clinical outcomes in acute ischemic stroke patients.
P5752Which is the best stenting technique for coronary bifurcation lesions? Evidence from a network meta-analysis of randomized clinical trials
Authors: Chiabrando J , Lombardi M , Vescovo G M , Biondi Zoccai G , Abbate A , Wohlford G , Berrocal D H , Guzman L 
Published: October 2019

Abstract

Background
Bifurcation lesions represent 20% of all coronary lesions treated by percutaneous coronary interventions (PCI). Although provisional technique with 1 stent in the main branch and balloon angioplasty of the side branch is considered the standard approach, the implantation of 2 stents is often being pursued with a wide variety of bifurcation stenting techniques. We thus conducted a systematic review and network meta-analysis of randomized clinical trials (RCTs) to compare clinical cardiovascular outcomes involving stenting techniques in coronary bifurcation lesions.

Methods
We searched on Pubmed, Google Scholar, Embase and Cochrane Library, up to October 2018 for published and unpublished RCTs that compared clinical cardiovascular outcomes in patients with bifurcation lesions treated with 7different techniques (crush [Cr]; culotte [Cu]; double kissing crush [DKCr], mini-crush [mCr], routine T-stenting [RTS], T-stenting and small protrusion [TAP], and provisional (1 stent technique)). We performed a frequentist fixed-effect network meta-analysis to estimate relative risks (RR) of major adverse cardiovascular events (“MACE”, typically defined as death, myocardial infarction and target vessel revascularization), target vessel revascularization (TVR), target lesion revascularization (TLR), and stent thrombosis (ST).

Results
We identified 14 studies, yielding data on 4285 patients. DKCr and mCr yielded significant reductions in MACE, TVR, and TLR when compared with the 1-stent technique (RR 0.31–0.55 [all P<0.01] and RR 0.42–0.45 [all P<0.02], respectively) and with the rest of the bifurcation techniques (RR 0.44–0.55 [all P<0.05] for DKCr and RR 0.37–0.45 [all P<0.05] for mCr). On the other hand, Cu and Cr were associated with an increased risk for ST compared to 1-stent technique (RR 3.25–4.27 [both P<0.05]) and to DKCr (RR 3.02–3.99 [both P<0.05]). We found no heterogeneity nor inconsistency between studies.

Conclusions
The various PCI bifurcation stenting techniques are associated with different cardiovascular outcomes, with double kissing crush and mini crush being more effective than others, including the 1-stent approach, whereas culotte and crush are associated with increased risk of stent thrombosis.

Acknowledgement/Funding
None