bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable production of FAEE biodiesel using the oleaginous yeast Yarrowia lipolytica
Authors: Yu Aiqun , Zhao Yu , Li Jian , Li Shenglong , Pang Yaru , Zhao Yakun , Zhang Cuiying , Xiao Dongguang 
Published: April 2020

AbstractFatty acid ethyl esters (FAEEs) are fatty acid‐derived molecules and serve as an important form of biodiesel. The oleaginous yeast Yarrowia lipolytica is considered an ideal host platform for the production of fatty acid‐derived products due to its excellent lipid accumulation capacity. In this proof‐of‐principle study, several metabolic engineering strategies were applied for the overproduction of FAEE biodiesel in Y. lipolytica. Here, chromosome‐based co‐overexpression of two heterologous genes, namely, PDC1 (encoding pyruvate decarboxylase) and ADH1 (encoding alcohol dehydrogenase) from Saccharomyces cerevisiae, and the endogenous GAPDH (encoding glyceraldehyde‐3‐phosphate dehydrogenase) gene of Y. lipolytica resulted in successful biosynthesis of ethanol at 70.8 mg/L in Y. lipolytica. The engineered Y. lipolytica strain expressing the ethanol synthetic pathway together with a heterologous wax ester synthase (MhWS) exhibited the highest FAEE titer of 360.8 mg/L, which is 3.8‐fold higher than that of the control strain when 2% exogenous ethanol was added to the culture medium of Y. lipolytica. Furthermore, a synthetic microbial consortium comprising an engineered Y. lipolytica strain that heterologously expressed MhWS and a S. cerevisiae strain that could provide ethanol as a substrate for the production of the final product in the final engineered Y. lipolytica strain was created in this study. Finally, this synthetic consortium produced FAEE biodiesel at a titer of 4.8 mg/L under the optimum coculture conditions.
Examining the design, manufacturing and analytics of smart wearables
Authors: Lopez Ximena , Afrin Kahkashan , Nepal Bimal 
Published: April 2020

AbstractRecent advancements in sensors, device manufacturing and big data technologies have enabled the design and manufacturing of smart wearables for a wide array of applications in health care. These devices can be used to remotely monitor and diagnose various diseases and aid in the rehabilitation of patients. Smart wearables are an unobtrusive and affordable alternative to costly and time‐consuming healthcare efforts such as hospitalization and late diagnosis. Developments in micro‐ and nanotechnologies have led to the miniaturization of sensors, hybrid 3D printing of flexible plastics, embedded electronics and intelligent fabrics, as well as wireless communication mediums that permit the processing, storage and communication of data between patients and healthcare facilities. Due to these complex component architectures that comprise smart wearables, manufacturers have faced a number of problems, including minimum sensor configuration, data security, battery life, appropriate user interfaces, user acceptance, proper diagnosis and many more. There has been a significant increase in interest from both the academic and industrial communities in research and innovation related to smart wearables. However, as smart wearables integrate several different aspects such as design, manufacturing and analytics, the existing literature is quite widespread, making it less accessible for researchers and practitioners. The purpose of this study was to narrow this gap by providing a state‐of‐the‐art review of the extant design, manufacturing and analytics literature on smart wearables—all in one place—thereby facilitating future work in this rapidly growing field of research and application. Lastly, it also provides an in‐depth discussion on two very important challenges facing the smart wearable devices, which include barriers to user adoption and the manufacturing technologies of the wearable devices.
Lymphovenous anastomosis (LVA) for treatment of iatrogenic lymphocele in the thigh
Authors: Scaglioni Mario F. , Meroni Matteo , Fritsche Elmar 
Published: April 2020

AbstractBackgroundLymphocele is a collection of lymphatic fluid within the body. It is caused by an impairment of lymph drainage and often occurs after a surgical intervention. In this setting conservative treatment is usually ineffective. The aim of this report is to share the outcomes of 11 patients with iatrogenic lymphocele in the thigh area treated by supermicrosurgical lymphovenous anastomosis.Patients and MethodsEleven patients presenting iatrogenic lymphocele in the thigh were referred for surgery after an unsuccessful conservative therapy. Patients’ mean age was 56 years old, two males and nine females. All of them presented a moderate‐to‐severe lymphocele in the medial thigh after a surgical intervention that damaged the rich lymphatic pathway present there. Indocyanine green (ICG) lymphography was always performed to visualize the lymphatic vessels and to make the preoperative marking.ResultsAll the 11 patients were successfully treated by means of one or more (range: 1–3; mean: 1.5) lymphaticovenous anastomoses without complications. Three of them also received a pedicled sartorius flap for dead space obliteration. All the patients reached full range of motion (ROM) and no recurrences were observed during follow up (range: 6–12 months; mean: 8). Intra‐operative ICG lymphography was performed in all cases to check the patency of the anastomoses.ConclusionsLymphaticovenous anastomosis confirmed to be a minimally‐invasive and effective procedure for the treatment of postsurgical lymphoceles in the leg. For large lymphoceles a muscle flap may be indicated for volume restoration and prevention of recurrences.
Chronic pain 1–5 years after heart transplantation—A nationwide cross‐sectional cohort study
Authors: Dalvindt Marita , Kisch Annika , Nozohoor Shahab , Lennerling Annette , Forsberg Anna 
Published: April 2020

AbstractAimTo provide a multidimensional assessment of self‐reported chronic pain 1–5 years after heart transplantation and its relationship with self‐reported well‐being, fatigue, recovery, self‐efficacy and socio‐economic factors and to explore differences between heart recipients and a cohort of lung recipients.DesignThis multicentre, cross‐sectional, cohort study is a part of the Swedish national Self‐management after thoracic transplantation study.MethodsSix questionnaires were distributed at the heart recipients yearly follow‐up (1–5 years) at three Swedish university hospitals 2014‐2017.ResultsThe study group comprised of 79 heart recipients, 25 women and 54 men with a mean age of 52.68 years. Chronic pain among heart recipients was common and those not in paid employment as well as those with low psychological well‐being and high general fatigue reported significantly more pain. Female heart recipients were more affected by pain. General health and vitality, general fatigue, physical fatigue and reduced activity were related to the pain intensity score.Relevance to clinical practiceAs it is the duty of the healthcare system to provide adequate pain treatment, screening for pain should be a mandatory part of long‐term follow‐up.
Detailing the elementary stages in the oxirane ring opening reactions with carboxylic acids catalyzed by tertiary amines
Authors: Bakhtin Stanislav , Shved Elena , Bespalko Yuliia , Tyurina Tatyana , Palchykov Vitalii 
Published: April 2020

AbstractThe study of the reaction systems “R3N – proton‐donor reagent (NuH) – epichlorohydrin” using a complex of various kinetic methods of investigation allowed the reaction pathway and the catalysis mechanism of the oxirane ring opening by proton‐donor reagents in the presence of R3N to be detailed. It was confirmed that the catalytic activity of R3N consists in their quaternization by oxirane under the obligatory condition of its electrophilic assistance with the NuH reagent. The quaternization process of tertiary amines was studied using 1H NMR and UV spectroscopy, quantum chemical modeling, and correlation analysis. It was shown that the transition states of the quaternization stage are dissociative, and their degree of looseness depends on the electrophilic activation of the oxirane ring.
Novel sulfone derivatives containing a 1,3,4‐oxadiazole moiety: design and synthesis based on the 3D‐QSAR model as potential antibacterial agent
Authors: Chen Jixiang , Luo Yuqin , Wei Chengqian , Wu Sikai , Wu Rong , Wang Shaobo , Hu Deyu , Song Baoan 
Published: April 2020

AbstractBACKGROUNDThe rice bacterial leaf blight (BLB) is one of the most serious bacterial diseases caused by Xanthomonas oryzae pv. oryzae (Xoo), which can cause yield loss of rice up to 50%. The three‐dimensional quantitative structure–activity relationship (3D‐QSAR) is an important auxiliary method to find potential high‐efficient pesticides active structures.RESULTSA series of novel 1,3,4‐oxadiazole compounds were designed and synthesized based on the 3D‐QSAR model, and their antibacterial activities in vitro against Xoo were evaluated. The results indicated that all the target compounds showed excellent in vitro antibacterial activities. For example, the compounds 6, 12, 13, 20, 21, and 23 exhibited excellent antibacterial activities against Xoo, with half‐maximal effective concentration (EC50) values of 0.24, 0.31, 0.36, 0.29, 0.19, and 0.31 mg/L, respectively, which were superior to the antibacterial agents thiodiazole copper (127.44 mg/L) and bismerthiazol (91.08 mg/L). Meanwhile, compound 21 showed good antibacterial activity in vivo against BLB, with curative and protective activities of 46.7% and 56.4%, respectively, which were superior to thiodiazole copper (28.5% and 32.5%) and bismerthiazol (37.6% and 38.4%). Compound 21 can significantly reduce the extracellular polysaccharides production of Xoo, increase the permeability of the cell membranes, and also can cause cell surface wrinkles, deformation and dryness.CONCLUSIONThe 3D‐QSAR model can be used to find sulfone compounds containing a 1,3,4‐oxadiazole moiety with higher antibacterial activity, and compound 21 can be used as a potential antibacterial agent in the future. © 2020 Society of Chemical Industry
Stability analysis of a control system with nonlinear input uncertainty based on disturbance observer
Authors: Umemoto Kazuki , Endo Takahiro , Matsuno Fumitoshi , Egami Tadashi 
Published: April 2020

SummaryIn disturbance observer (DO)‐based control, control input attenuates a disturbance using observer output. Thus, the input may not achieve the attenuation if the input term includes uncertainty. Therefore, in order to correctly suppress the disturbance, it is essential to consider the uncertainty existing in the input term, and thus this article focuses on a nonlinear uncertainty in the input term. This article analyzes the stability and robustness of a DO‐based nonlinear control system with both the disturbance and the input uncertainty. We address the case that the disturbance and the uncertainty depend on time and states of a controlled system. The disturbance and the uncertainty are gathered in an integrated disturbance, and the integrated disturbance depends on many variables: the states, the control input, and the time. Therefore, a norm estimations for the disturbance and a time variation of the disturbance is difficult without knowledge of the state trajectory. Hence, a slope‐restriction for the disturbance is used for the stability analysis. Based on the mathematical analysis, we show input‐to‐state stability conditions due to extend the application class of the DO‐based controller to a control system with the disturbance and the nonlinear input uncertainty. The analytical results are verified by numerical simulations.
Electrochemical Performance of BiF3‐BaF2 Solid Solution with Three Different Phases on a Fluoride Shuttle Battery System
Authors: Konishi Hiroaki , Minato Taketoshi , Abe Takeshi , Ogumi Zempachi 
Published: April 2020

AbstractSolid solution of bismuth(III) fluoride (BiF3) and barium(II) fluoride (BaF2) with a variety of crystal structures was prepared, and their electrochemical performances were evaluated on a fluoride shuttle battery (FSB) system. BiF3‐BaF2 based solid solution (Bi1‐xBaxF3‐x (x=0) with orthorhombic phase, x=0.2 with hexagonal phase, and x=0.4 with cubic phase) were successfully obtained with the mechanical alloy method. The change from Bi1‐xBaxF3‐x (x=0) (orthorhombic) to x=0.2 (hexagonal) improved the initial reversible capacity and the capacity retention during cycling. The change from x=0.2 (hexagonal) to 0.4 (cubic) led to further improvement in capacity retention during cycling; however, the initial reversible capacity decreased due to the substitution of excess amount of barium that did not contribute to the redox reaction. For the BiF3‐based compound, controlling the crystal structure and substitution of inactive element affected the FSB performance.
Extraction of Alkaloids from Coptidis Rhizoma via Betaine‐Based Deep Eutectic Solvents
Authors: Li Yuanbin , Hsieh Yun‐Hao , Pan Zuchen , Zhang Ling , Yu Wen , Wang Binshen , Zhang Jiaheng 
Published: April 2020

AbstractTo avoid the use of volatile organic compounds, a series of betaine‐based deep eutectic solvents (DESs), which are considered as green solvents, were prepared for the efficient extraction of alkaloids from coptidis rhizome. The extraction conditions were optimized via response surface methodology (RSM) to achieve the maximum recovery of total alkaloids. A central composite design with three independent variables which included the concentration of the selected DES, extraction time, and solvent/solid ratio at five levels, was applied while response surface plots were produced with a second order polynomial model. A one‐off experiment was performed to examine the reliability of the simulated results obtained from RSM. An optimized yield of 128.43 mg/g was obtained at an extraction time of 29.5 min and a solvent/solid ratio of 35 : 1 with the extraction solvent as 0.6 M betaine‐tartaric acid‐ water DES.
The effects of synthetic wollastonite developed with calcite and quartz on high performance mortars
Authors: Öz Hatice Öznur , Güneş Muhammet 
Published: April 2020

AbstractIn this study, the effects on high performance mortar (HPM) of synthetic wollastonite (SW) mineral were researched. Through this work, firstly, wollastonite was synthetically obtained by a particular production method. Secondly, SW was utilized as cement replacement material from 0 to 12% by 3% steps of increment in the production of HPM. After determination of slump flow diameters of HPMs, mechanical and durability properties were observed at 28 and 90 days. Additionally, microstructural performance properties of HPMs designed with SW in the ratios 0, 9, and 12% was specified with TGA/DTA and FTIR analysis as well as SEM/EDX and XRD analysis. The test and analysis results showed that SW decreased the workability of HPMs. The improvement of the mechanical and durability properties of HPMs proceeded up to 9% of SW. Microstructural analysis showed that development effect of SW on the HPM can be attributed to its needle‐shaped structure.
Evaluation of Systematic Errors in the Compact Absolute Gravimeter TAG-1 for Network Monitoring of Volcanic Activities
Authors: Araya Akito , Kasai Keisuke , Yoshida Masato , Nakazawa Masataka , Tsubokawa Tsuneya 
Published: April 2020

AbstractVolcanic activities sometimes involve gravity changes, and this research is intended to establish an observation network surrounding an active volcano using compact absolute gravimeters. To simplify the configuration of absolute gravimeters, they are preferably operated with a light source distributed from a telecom band (wavelength of 1.5 μm) laser through optical fibers. To evaluate the accuracy of the absolute gravimeter with the telecom band laser, we conducted observations using a prototype gravimeter (TAG-1) with frequency-stabilized lasers at both 1.5 μm and 633 nm, and compared these results with the expected gravity at the site. Initially, both results showed offsets −187 μGal and −9.6 μGal for the 1.5-μm laser and the 633-nm laser, respectively (1 Gal = 10−8 m/s2). By correcting the systematic errors of the photo detectors measured by the synthetic chirp signal, the obtained absolute gravity was consistent with the expected value for both wavelengths; offsets from the expected gravity were reduced to 6.6 μGal and 5.4 μGal for 1.5 μm and 633 nm, respectively. We also evaluated the errors associated with long-distance transmission of the 1.5-μm laser using a reeled optical fiber (26 km) and an optical amplifier and found no degradation in the gravity data from the case of short transmission (10 m). These results allow networking of compact absolute gravimeters connected by telecom optical fibers that are operated using a common laser and expansion to volcanic areas to monitor the gravity change associated with volcanic activities.
Connected Floer homology of covering involutions
Authors: Alfieri Antonio , Kang Sungkyung , Stipsicz András I. 
Published: April 2020

AbstractUsing the covering involution on the double branched cover of $$S^3$$

S
3

branched along a knot, and adapting ideas of Hendricks–Manolescu and Hendricks–Hom–Lidman, we define new knot (concordance) invariants and apply them to deduce novel linear independence results in the smooth concordance group of knots.
Nationwide Analysis of Urinary Retention Following Inguinal Hernia Repair: Results from the National Prospective Hernia Registry
Authors: Drissi Farouk , Gillion Jean‐François , Roquilly Antoine , Luyckx François , Duchalais Emilie ,   For Club Hernie
Published: April 2020

AbstractBackgroundUrinary retention is one of the most common early postoperative complications following inguinal hernia repair (IHR). The aim of this study was to assess the incidence of postoperative urinary retention (POUR) and to identify associated risk factors.MethodData of consecutive patients undergoing IHR from 2011 to 2017 were collected from a national multicenter cohort. POUR was defined as the inability to void requiring urinary catheterization. A multivariate analysis was conducted to identify independent risk factors for POUR.ResultsOf 13,736 patients, 109 (0.8%) developed POUR. Patients with POUR had longer hospital length of stay (p < 0.001). IHR was performed by a laparoscopic or an open approach in 7012 (51.3%) and 6655 (48.7%) patients, respectively, and spinal anesthesia was realized in 591 (4.3%) patients. Ambulatory surgery was performed in 10,466 (76.6%) patients. Multivariate analysis identified preoperative dysuria (0R 3.73, p < 0.001), diabetes mellitus (OR 1.98, p = 0.029) and spinal anesthesia (OR 7.56, p < 0.001) as independent preoperative risk factors associated with POUR. POUR was the cause of ambulatory failure in 35 (10.2%) patients who required unanticipated admission.ConclusionThe incidence of POUR following IHR remains low but impacts hospitalization settings. Preoperative risk factors for POUR should be considered for the choice of the anesthetic technique.
Application of PECARN rules would significantly decrease CT rates in a Dutch cohort of children with minor traumatic head injuries
Authors: Niele Nicky , van Houten Marlies , Tromp Ellen , van Goudoever J.B. , Plötz Frans B. 
Published: April 2020

AbstractThe aim of this study was to determine the potential impact of the Pediatric Emergency Care Applied Research Network (PECARN) rules on the CT rate in a large paediatric minor traumatic head injury (MTHI) cohort and compare this with current national Dutch guidelines. This was a planned sub-study of a prospective multicentre observational study that enrolled 1006 children younger than 18 years with MTHI. We calculated the number of recommended CT scans and described trauma-related CT scan abnormalities. The PECARN rules recommended a significantly lower percentage of CT scans in all age categories, namely 101/357 (28.3%) versus 164/357 (45.9%) (p < 0.001) in patients under 2 years of age and 148/623 (23.8%) versus 394/623 (63.2%) (p < 0,001) versus in patients 2 years and older.Conclusion: The projected CT rate can significantly be reduced if the PECARN rules are applied. We therefore advocate that the PECARN guidelines are also implemented in The Netherlands.

What is Known:• To guide clinicians whether to perform a CT scan in children with a minor traumatic head injury (MTHI) clinical decision rules has been developed.• The overall CT scan rate in adherence with the Dutch MTHI guidelines is 44%.

What is New:• The projected CT rate can significantly be reduced in a Dutch cohort of MTHI if the PECARN rules are applied.• The Dutch national guidelines for MTHI can safely be replaced by the PECARN rules.
Belief Changes and Cognitive Development: Doxastic Logic $${\mathsf {LCB}}$$
Authors: Łyczak Marcin 
Published: April 2020

AbstractWe present the logic$${\mathsf {LCB}}$$LCBwhich is expressed in a propositional language constantly enriched by new atomic expressions. Our formal framework is the propositional doxastic logic$${\mathsf {KD45}}$$KD45with the belief operator$${\mathcal {B}}$$B, extended by the$${\mathcal {C}}$$Coperator, to be readit changes that .... We describe the changing beliefs of an agent who uses progressively expanding language. The approach presented here allows us to weaken pragmatic objections to the so-called principle ofnegative retrospectionaccepted in$${\mathsf {KD45}}$$KD45and the problem oflogical omniscience. In what follows, we present the expanding propositional language used in our formalism, interpreted using an epistemic version of Kripke semantics. Next, we give a syntactic characterization of logic$${\mathsf {LCB}}$$LCBand prove the soundness and completeness of$${\mathsf {LCB}}$$LCBin respect to our semantics. Finally, we compare the idea of expanding language with the notion ofagent awarenessand we relate our formalism to two epistemic temporal logics.
Reconceptualizing Moral Disengagement as a Process: Transcending Overly Liberal and Overly Conservative Practice in the Field
Authors: Schaefer Ulf , Bouwmeester Onno 
Published: April 2020

AbstractMoral disengagement was initially conceptualized as a process through which people reconstrue unethical behaviors, with the effect of deactivating self-sanctions and thereby clearing the way for ethical transgressions. Our article challenges how researchers now conceptualize moral disengagement. The current literature is overly liberal, in that it mixes two related but distinct constructs—process moral disengagement and the propensity to morally disengage—creating ambiguity in the findings. It is overly conservative, as it adopts a challengeable classification scheme of “four points in moral self-regulation” and perpetuates defining moral disengagement via a set of eight psychological mechanisms, narrowing our understanding of the phenomenon. To address these problems, we propose to define process moral disengagement intensionally (specifying the necessary and sufficient conditions for correct application of the term) as intrapsychic cognitive reasoning processes through which people selectively reconstrue a moral judgment “behavior B by actor A is morally wrong” and shift it toward becoming “behavior B is not morally wrong” or “actor A is not responsible for behavior B.” This definition achieves disambiguation and increased concept clarity. We leverage the definition to motivate a classification scheme for psychological mechanisms of moral disengagement along two dimensions—reconstruing morality and reconstruing agency—and to initiate an open inventory of psychological mechanisms that specify how process moral disengagement operates.