bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 Obstetrics Task Force, Lombardy, Italy: Executive management summary and short report of outcome
Authors: Ferrazzi Enrico M. , Frigerio Luigi , Cetin Irene , Vergani Patrizia , Spinillo Arsenio , Prefumo Federico , Pellegrini Edda , Gargantini Gianluigi 
Published: April 2020

AbstractFrom February 24, 2020, a COVID‐19 obstetric task force was structured to deliver management recommendations for obstetric care. From March 1, 2020, six COVID‐19 hubs and their spokes were designated. An interim analysis of cases occurring in or transferred to these hubs was performed on March 20, 2020 and recommendations were released on March 24, 2020. The vision of this strict organization was to centralize patients in high‐risk maternity centers in order to concentrate human resources and personal protective equipment (PPE), dedicate protected areas of these major hospitals, and centralize clinical multidisciplinary experience with this disease. All maternity hospitals were informed to provide a protected labor and delivery room for nontransferable patients in advanced labor. A pre‐triage based on temperature and 14 other items was developed in order to screen suspected patients in all hospitals to be tested with nasopharyngeal swabs. Obstetric outpatient facilities were instructed to maintain scheduled pregnancy screening as per Italian guidelines, and to provide pre‐triage screening and surgical masks for personnel and patients for pre‐triage‐negative patients. Forty‐two cases were recorded in the first 20 days of hub and spoke organization. The clinical presentation was interstitial pneumonia in 20 women. Of these, seven required respiratory support and eventually recovered. Two premature labors occurred.
Binding of Leishmania spp with gold nanoparticles supported polyethylene glycol and its application for the sensitive detection of infectious photogenes in human plasma samples: A novel biosensor
Authors: Mobed Ahmad , Mehri Parina , Hasanzadeh Mohammad , Mokhtarzadeh Ahad 
Published: April 2020

AbstractThe management of pathogen detection using a rapid and cost‐effective method presents a major challenge to the biological safety of the world. The field of pathogen detection is nascent and therefore, faces a dynamic set of challenges as the field evolves. Visceral leishmaniasis (VL), or kala‐azar is the most severe form of leishmaniasis. Delay to the accurate diagnosis and treatment is likely to lead to fatality. The reliable, fast and sensitive detection is closely linked to safe and effective treatment of Leishmania spp. Despite several routine and old method for sensitive and specificity detection of Leishmania spp, there is highly demand for developing modern and powerfully system. In this study a novel ultra‐sensitive DNA‐based biosensor was prepared for detection of Leishmania spp. For the first time, the specific and thiolated sequences of the Leishmania spp genome (5′‐SH‐[CH2]6 ATCTCGTAAGCAGATCGCTGTGTCAC‐3′) were recognized by electrochemical methods. Also, selectivity of the proposed bioassay was examined by three sequences that were mismatched in 1, 2, and 3 nucleotides. The linear range (10−6 to 10−21 M) and limit of detection (LLOQ = 1 ZM) obtained are remarkable in this study. Also, simple and cost‐effective construction of genosensors was another advantage of the proposal DNA‐based assay. The experimental results promise a fast and simple method in detection of kala‐azar patients with huge potential of the nanocomposite‐based probe for development of ideal biosensors.
Analysis of the thermogenesis mechanism of natural rubber under high speed strain
Authors: Zhan Yue‐Hua , Wei Yan‐Chan , Zhang Hui‐Feng , Luo Ming‐Chao , Zheng Ting‐Ting , Liao Shuangquan 
Published: April 2020

AbstractThis work highlights the relationship of crosslink density, entanglement points and various sulfide crosslinks with the thermogenesis properties of natural rubber (NR). The impact of cross‐link and entanglement on thermogenesis properties was evaluated by heat build‐up test, swelling behavior, statistical thermodynamic calculation, and classic viscoelastic theory. It was found that cross‐link and entanglement points have “pinning” effect to the rubber chain, thus remarkably restricting the motion of the rubber chain and reducing thermogenesis. Besides, the effects of various sulfide crosslinks and cross‐link length on thermogenesis were compared and discussed varying the sulfur vulcanization system. It was found that the semi‐effective vulcanization system using N‐cyclohexyl‐2‐benzothiazolesulfenamide (CZ) and 2‐Mercaptobenzothiazole (M) has the lowest thermogenesis (bottom temperature rise is 7.5°C, middle is 18.7°C), which on account of combined short crosslink length with high rigid rubber chain (crosslink network dominated by mono‐ and disulfides). As a result, the deformation degree of the rubber chain during curl up‐extension and the thermogenesis are further reduced. Finally, a combination of natural film coagulation and semi‐effective vulcanization system was used to prepare a low thermogenesis NR, in which bottom and middle temperature rise were only 5.0°C and 14.1°C, respectively.
Efficient Pyrazole Moiety‐Containing Ligands for Cu‐Catalyzed O‐Arylation of Phenols
Authors: Zhao Yingying , Wang Xiangyong , Kaneyama Ryo , Kodama Koichi , Hirose Takuji 
Published: April 2020

AbstractSeven pyrazole‐ or pyridine‐containing N2‐ and N3‐ligalitnds (L1–L7) were developed for the ligand‐assisted CuI‐catalyzed coupling reactions of aryl halides with phenols. The structural and electronic effects were studied for various combinations of pyridine and/or imine nitrogen binding sites in the ligands. Screening their abilities showed most of them to be better than 4,4’‐dimethoxybipyridine (L8). Among them, 2‐(1‐pyrazolyl)pyridine (L1) featuring two types of binding sites gave the best results, with yields of up to 95% at 100 °C at a catalyst loading of 10 mol% (CuI/L in 1 : 1 ratio). Free radical scavengers, 2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) (1.0 eq.) and cumene (1.0 eq.), lowered the yields by more than half, but the reaction was not completely quenched even when 3.0 eq. of TEMPO was used. A non‐radical and a radical mechanisms, are proposed for the L1‐promoted coupling reaction, well explained the experiments results. In addition, the structure of the catalyst species were elucidated through single crystal XRD and DFT (density functional theory) calculations.
MFHS: A modular scheduling framework for heterogeneous system
Authors: Khiat Abdelhamid , Tari Abdelkamel , Guérout Tom 
Published: April 2020

SummaryCurrent innovative distributed architectures, proposing on‐line services, involve more and more computing resources. From a provider point of view, the platform management leads to challenging problematic relating to resource allocation, which involve different kind of quality of service parameters, the provider has to focus on to keep his platform reliable and efficient. MFHS is a modular generic framework, which can be adapted to any distributed computing environment. Structured in modules, MFHS allows to discover the existing computing resources in terms of computing performance, network throughput and disk I/O speeds (Resources Discovery module) and to predict how the experiment should behave (Pi value). As the setting up of real experiments is often complex, MFHS allows: to make theoretical experimentation (based on models), to use any kind of distributed emulators, or to deploy experiments on real‐experimental platforms. In this article, these three environments are used to highlight the reliability of MFHS (measured Pi=90% against 94% for the predicted Pi). Deployment and scheduling studies have also been achieved using an experimental Cloud based on OpenStack while Emulab test‐bed has been used as emulator. During experiments, four QoS parameters are taken into account (Resources Monitoring module): energy consumption, cost, resource utilization, and makespan. These studies also includes a new heuristic called MMin, based on Max‐Min and Min‐Min algorithms. Experimentation section, proposes a detailed comparative analysis of these algorithms in terms of QoS results, while the abilities of the proposed heuristic MMin regarding the makespan metric is shown.
UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program
Authors: Iliodromiti S. , Smith G. C. S. , Lawlor D. A. , Pell J. P. , Nelson S. M. 
Published: April 2020

ABSTRACTObjectiveUse of the Growth Assessment Protocol (GAP) has increased internationally under the assumption that it reduces the stillbirth rate. The evidence for this is limited and based largely on an ecological time‐trend study. Discordance in the uptake of the GAP program between Scotland and England/Wales enabled us to assess the assertion that implementation of GAP leads to a reduced stillbirth
rate.MethodsWe analyzed data from the National Records for Scotland and the Office for National Statistics on the number of singleton maternities and stillbirths in Scotland and in England and Wales, respectively, from 1 January 2000 to 31 December 2015. National uptake of the GAP program over time in each of the regions was recorded. Stillbirth rate per 1000 maternities was calculated, according to year of delivery, and compared between Scotland and England/Wales.ResultsDuring the study period, there were 870 632 singleton maternities in Scotland, of which 4243 were stillbirths, and there were 10 469 120 singleton maternities in England and Wales, of which 51 562 were stillbirths. There was a marked difference in uptake of the GAP program between the two regions, with substantially fewer maternity units in Scotland implementing the program. Stillbirth rates were static up to 2010, with a decline thereafter in both regions, to 3.75 (95% CI, 3.25–4.30) per 1000 maternities in Scotland and 4.30 (95% CI, 4.15–4.46) per 1000 maternities in England and Wales in 2015. From 2010 onwards, the decline in Scotland was faster, equating to 48 (95% CI, 47.9–48.1) fewer stillbirths per 100 000 maternities in Scotland than in England and Wales from 2010 to 2015 compared with 2000 to 2009.ConclusionsWe observed a decline in stillbirth rate in England and Wales, which coincided with implementation of the GAP program. However, a concurrent decline in stillbirth rate was observed in Scotland in the absence of increased implementation of GAP. The secular rates of change in stillbirth rate in England and Wales cannot be used to infer efficacy of the GAP program. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Genetic variation of Brucella isolates at strain level in Egypt
Authors: Abdel‐Hamid Nour H. , El‐bauomy Essam M. , Ghobashy Hazem M. , Shehata Abeer A. 
Published: April 2020

AbstractIn this study, Multiple Locus Variable Number Tandem Repeat Analysis (MLVA‐16) was performed on 18 Brucella isolates identified bacteriologically and molecularly (AMOS‐PCR) as Brucella abortus (n = 6) and Brucella melitensis (n = 12). This was aimed to study the genetic association among some Egyptian Brucella genotypes isolated during the period from 2002 to 2013 along with the global genotypes database. MLVA‐16 analysis for B. melitensis and B. abortus strains illustrates a total of 11, and 3 genotypes with 10 and 1 singleton genotypes, respectively. B. melitensis strains displayed greater markers diversity by VNTRs analysis of the 16 loci than B. abortus and this was attributed mainly to the diverging in panel 2B markers. B. melitensis genotype M4_Fayoum_Giza (3,5,3,13,1,1,3,3,8,21,8,7,5,9,5,3) was the only predominated genotype circulating between two different governorates. The most common B. abortus genotype, GT A3_Dakahlia (4,5,4,12,2,2,3,3,6,21,8,4,4,3,4,4), was present in three identical isolates. In phylogeny, Egyptian B. abortus bv1 genotypes were closely related to East Asian strain (for the first time), Western Mediterranean and Americas clonal lineages. B. melitensis local genotypes exhibit a genetic relatedness mostly to Western Mediterranean clonal lineage and one strain of Eastern Mediterranean clonal lineage. In conclusion, the geographic location is not the only factor stands behind the high genetic similarity of the Egyptian Brucella genotypes. These low variations may be a result of a stepwise mutational event of the most variable loci from a very limited number of ancestors especially during the transmission through non‐preference hosts. The authors encourage the authorities in charge to establish pre‐movement testing to reduce the risk of brucellosis spread.
Molecular mechanisms regulating synaptic specificity and retinal circuit formation
Authors: Graham Hannah K. , Duan Xin 
Published: April 2020

AbstractThe central nervous system (CNS) is composed of precisely assembled circuits which support a variety of physiological functions and behaviors. These circuits include multiple subtypes of neurons with unique morphologies, electrical properties, and molecular identities. How these component parts are precisely wired‐up has been a topic of great interest to the field of developmental neurobiology and has implications for our understanding of the etiology of many neurological disorders and mental illnesses. To date, many molecules involved in synaptic choice and specificity have been identified, including members of several families of cell‐adhesion molecules (CAMs), which are cell‐surface molecules that mediate cell‐cell contacts and subsequent intracellular signaling. One favored hypothesis is that unique expression patterns of CAMs define specific neuronal subtype populations and determine compatible pre‐ and postsynaptic neuronal partners based on the expression of these unique CAMs. The mouse retina has served as a beautiful model for investigations into mammalian CAM interactions due to its well‐defined neuronal subtypes and distinct circuits. Moreover, the retina is readily amenable to visualization of circuit organization and electrophysiological measurement of circuit function. The advent of recent genetic, genomic, and imaging technologies has opened the field up to large‐scale, unbiased approaches for identification of new molecular determinants of synaptic specificity. Thus, building on the foundation of work reviewed here, we can expect rapid expansion of the field, harnessing the mouse retina as a model to understand the molecular basis for synaptic specificity and functional circuit assembly.This article is categorized under:

Nervous System Development > Vertebrates: General Principles
Nervous System Development > Vertebrates: Regional Development
Super-resolution microscopy unveils transmembrane domain-mediated internalization of cross-reacting material 197 into diphtheria toxin-resistant mouse J774A.1 cells and primary rat fibroblasts in vitro
Authors: Fellermann Maximilian , Wondany Fanny , Carle Stefan , Nemeth Julia , Sadhanasatish Tanmay , Frick Manfred , Barth Holger , Michaelis Jens 
Published: April 2020

AbstractDiphtheria toxin (DT) efficiently inhibits protein synthesis in human cells, resulting in severe disease diphtheria. The sensitivity towards DT varies between mammalian species. Mice and rats are resistant to DT. However, the reason underlying this insensitivity is controversially discussed and not well understood. Therefore, we investigated the steps of DT uptake, i.e. receptor binding and internalization into mouse J774A.1 macrophages and primary rat fibroblasts. We exploited the non-toxic DT-mutant cross-reacting material 197 (CRM197) and three additional receptor binding-deficient mutants (250 nM each) to investigate binding to cell surface and internalization into murine cells via flow cytometry and stimulated emission depletion (STED) super-resolution optical microscopy. Dual-color STED imaging unveiled CRM197 interacting with the murine precursor of the heparin-binding epidermal growth factor-like growth factor (HB-EGF). Moreover, we identified CRM197’s transmembrane domain as an additional HB-EGF binding site, which is also involved in the receptor-mediated internalization into murine cells. However, we do not find evidence for translocation of the catalytically active subunit (DTA) into the cytosol when 250 nM DT were applied. In conclusion, we provide evidence that the resistance of murine cells to DT is caused by an insufficiency of DTA to escape from endosomes and reach the cytosol. Possibly, a higher affinity interaction of DT and the HB-EGF is required for translocation, which highlights the role of the receptor in the endosomes during the translocation step. We extend the current knowledge about cellular uptake of the medically relevant DT and CRM197.
The relationship between increased air pollution expressed as PM10 concentration and the frequency of percutaneous coronary interventions in patients with acute coronary syndromes—a seasonal differences
Authors: Januszek Rafał , Staszczak Bartłomiej , Siudak Zbigniew , Bartuś Jerzy , Plens Krzysztof , Bartuś Stanisław , Dudek Dariusz 
Published: April 2020

AbstractThe aim of the presented study was to assess the relationship between air pollution expressed as particulate air matters less than 10 μm (PM10) and acute coronary syndromes (ACSs). In this observational study, we selected regions with low pollution according to PM10 (non-polluted) and with the highest pollution (polluted). The occurrence of percutaneous coronary interventions (PCIs) in patients with ACSs was matched according to the location. The current study included 7678 patients in polluted areas and 4327 patients from non-polluted regions. Analysing the period from January to December 2017, the number of patients undergoing angioplasty in monitored catheterization laboratories and the mean daily concentration of PM10 in all selected cities were calculated for each day. The annual average concentration of PM10 amounts to 50.95 μg/m3 in polluted and 26.62 μg/m3 in non-polluted cities (P < 0.01). The rise in PM10 pollution levels was related with the increased frequency of PCIs in patients with ACSs in polluted (P < 0.01) and non-polluted (P < 0.01) areas. In the non-polluted regions, the increase in PM10 concentration by every 1 μg/m3 causes 0.22 additional ACS angioplasties per week. In polluted regions, the same increase in PM10 concentration causes 0.18 additional ACS angioplasties per week. In non-winter weeks, the mean number of ACS PCIs expressed in promiles was lower than in winter weeks in polluted (P = 0.03) and non-polluted cities (P = 0.02). The study shows that the increase in air pollution expressed as PM10 concentration and winter time influences the frequency of ACS-related PCIs.
Zur Stabilität und Variabilität motivationaler Orientierungen angehender Lehrkräfte im Verlauf des Integrierten Semesterpraktikums
Authors: Bauer Max , Traub Silke , Kunina-Habenicht Olga 
Published: April 2020

ZusammenfassungSchulpraktische Studien sollen als zentrale Lerngelegenheiten im Lehramtsstudium den Studierenden die Möglichkeit bieten, Praxiserfahrungen zu sammeln, Theorie mit Praxis zu verzahnen und ihre Berufswahlmotivation kritisch zu reflektieren. Bisherige Studien beschäftigten sich meist mit der Einschätzung subjektiver Kompetenzentwicklung und es gibt nur wenige Belege dafür, ob die Studierenden ihre Berufswahlmotivation im Verlauf der Praktika reflektieren und verändern. Diese Studie untersucht, wie stabil die motivationalen Orientierungen im Laufe des Integrierten Semesterpraktikums sind und welche Faktoren neben der reinen Praxiserfahrung eine Rolle für die möglichen Veränderungen spielen. Hierfür wurden 201 Studierende sowohl vor als auch nach ihrem Praktikum befragt. Die Ergebnisse der Strukturgleichungsmodellierungen zeigen, dass die Berufswahlmotive äußerst stabil sind und sich nur die Lehrerselbstwirksamkeit im Verlauf des Praktikums verändert. Die Untersuchung interindividueller Entwicklungsverläufe hat gezeigt, dass lediglich die Reflexionsgelegenheiten neben der reinen Praxiserfahrung einen kleinen positiven Effekt auf die Entwicklung der Lehrerselbstwirksamkeit aufweisen.
Orchestrating Governmental Corporate Social Responsibility Interventions through Financial Markets: The Case of French Socially Responsible Investment
Authors: Giamporcaro Stéphanie , Gond Jean-Pascal , O’Sullivan Niamh 
Published: April 2020

ABSTRACTAlthough a growing stream of research investigates the role of government in corporate social responsibility (CSR), little is known about how governmental CSR interventions interact in financial markets. This article addresses this gap through a longitudinal study of the socially responsible investment (SRI) market in France. Building on the “CSR and government” and “regulative capitalism” literatures, we identify three modes of governmental CSR intervention—regulatory steering, delegated rowing, and microsteering—and show how they interact through the two mechanisms of layering (the accumulation of interventions) and catalyzing (the alignment of interventions). Our findings: 1) challenge the notion that, in the neoliberal order, governments are confined to steering market actors—leading and guiding their behavior—while private actors are in charge of rowing—providing products and services; 2) show how governmental CSR interventions interact and are orchestrated; and 3) provide evidence that governments can mobilize financial markets to promote CSR.
Challenges to Australia's Offshore Detention Regime and the Limits of Strategic Tort Litigation
Authors: Holly Gabrielle 
Published: April 2020

AbstractAustralia's offshore detention regime has been the subject of numerous attempts to seek accountability for harm caused to detainees using legal and other avenues in Australia. This Article examines recent strategic litigation actions against the Australian government and the corporate contractors engaged in offshore detention, including: Kamasaee v. Commonwealth; AUB19 v. Commonwealth; and actions seeking injunctions requiring the Australian government to airlift detainees to Australia for medical treatment. While these actions have vindicated the rights of those in offshore detention in specific ways, and in some instances facilitated compensation for harms caused while in detention, none have proved capable of challenging the underlying basis of the offshore detention regime, nor of providing a foreseeable end to the detention, whether by facilitating credible prospects for resettlement, or by other means. The Article provides an account of the achievements and limitations of these claims and concludes that although certain features of the Australian jurisdiction make it possible to pursue transnational claims, and thus potentially provide remedy for those who have suffered wrongs in Australia's offshore detention regime, such claims need to be pursued with the utmost care and with careful consideration of the complexities of the Australian political and legal environment.
Exploring the Role of University-Run Enterprises in Technology Transfer from Chinese Universities
Authors: Li Xibao , Tan Justin 
Published: April 2020

ABSTRACTUniversities in China have increased their entrepreneurship significantly, yet a good understanding of the specific characteristics of university-based technology transfers remains missing. This study focuses on a special type of university spinoffs in China, University-Run Enterprises (UREs), and examines how URE eminence contributes to a university's technology transfer performance, using panel data covering 195 universities over the five years from 2002 to 2006. The findings reveal that URE eminence not only signifies a university's strong entrepreneurial culture, but also signals commercial values and quality of the university research. It moderates the contribution of university scientists from the supply side and that of sourcing firms from the demand side.