bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfectionism and insomnia in adolescents: The role of vulnerability to stress and gender
Authors: Richardson Cele , Gradisar Michael 
Published: October 2020

ABSTRACTIntroductionPerfectionism is an often overlooked yet consistent construct related to insomnia in the scientific literature. Perfectionism and insomnia are both highly prevalent in adolescence. However, there is a dearth of research examining mechanisms linking perfectionism with insomnia, particularly in young people. The current study aimed to investigate whether vulnerability to stress, a factor common to both constructs, accounts for the relationship between perfectionism and insomnia symptoms in a sample of adolescents.Methods281 Australian participants (Mage = 16.53, SD = 1.91, range = 13–19 years, 78% female) completed questionnaires assessing perfectionism, vulnerability to stress and insomnia on one occasion.ResultsVulnerability to stress accounted for the relationship between self‐oriented striving perfectionism, self‐oriented critical perfectionism and insomnia symptom severity in females, but not males. Females reported higher self‐oriented critical perfectionism, vulnerability to stress and insomnia severity, with a stronger relationship between vulnerability to stress and insomnia symptoms observed for females.ConclusionsThese results may partly explain the preponderance of insomnia in adolescent females. Possible implications for the prevention and treatment of insomnia in young people are discussed.
Smart design engineering: leveraging product design and development to exploit the benefits from the 4th industrial revolution
Authors: Pereira Pessoa Marcus Vinicius 
Published: October 2020

Abstract
The 4th industrial revolution (IR) requires new products and business models adjusted to the rapidly changing market conditions, which calls for evolutions in design engineering. In this context, smart design engineering is here defined as a methodology used during the analysis and design of a product or a system, which can be composed by hardware, software and/or services, and that explicitly considers exploiting the technologies and opportunities from the 4th IR. This work contributes to both design theory and practice: (i) it deepens the understanding about the necessary smart design engineering features and shows how these features impact the product design and development process’s (PDDP) key dimensions (procedures, people and tools); (ii) it maps the features’ impact on PDDP’s phases, thus providing practical direction for process improvement. To accomplish these results, a survey was performed on the initial features presented in the literature, which helped to identify new features and to confirm their relation to the 4th IR and their impact on the PDDP. These features were then analyzed against the 4th IR environment perspectives and core technologies, which led to understanding how they can be used to improve the PDDP.
VanA rectal swab screening as a predictor of subsequent vancomycin-resistant enterococcal bloodstream infection in critically ill adults
Authors: Kram Shawn J. , Kram Bridgette L. , Schultheis Jennifer M. , Kuhrt Michelle M. , McRae Andrew S. , Anderson Deverick J. 
Published: October 2020

AbstractObjective:To evaluate whether vanA rectal screening for vancomycin-resistant Enterococcus (VRE) predicts vancomycin resistance for patients with enterococcal bloodstream infection (BSI).Design:A retrospective cohort study.Setting:Large academic medical center.Methods:The predictive performance of a vanA rectal swab was evaluated in 161 critically ill adults with an enterococcal BSI from January 1, 2007, to September 1, 2014, and who had a vanA rectal swab screening obtained within 14 days prior to blood culture.Results:Of the patients meeting inclusion criteria, 83 (51.6%) were vanA swab positive. Rectal-swab–positive patients were more likely to be younger, to be immunocompromised, to have an indwelling central vascular catheter, and to have a history of MDR bacteria. The vanA rectal swab had sensitivity and negative predictive values of 83.6% and 85.9%, respectively, and specificity and positive predictive values of 71.3% and 67.5%, respectively, for predicting a vancomycin-resistant enterococcal BSI in critically ill adults.Conclusions:VanA rectal swabs may be useful for antimicrobial stewardship at institutions with VRE screening already in place for infection control purposes. A higher PPV would be warranted to implement a universal vanA screen on all ICU patients.
Imagined Communities and Imaginary Plots: Nationalisms, Conspiracies, and Pandemics in the Longue Durée
Authors: Malešević Siniša 
Published: October 2020

AbstractThe outbreaks of major pandemics have historically been associated with the proliferation of conspiracy theories. This article explores what role conspiratorial narratives have played in the development of different “imagined communities” in the premodern, modern, and contemporary worlds. I argue that premodern conspiratorial narratives were mostly focused on eschatological and theological images, aiming to blame and delegitimise the religious Other. In these imaginary plots, spread of disease was interpreted as an attack on one’s religious beliefs. The prevalence of religious conspiracies helped reinforce religiously based, yet temporary, “imagined communities.” With the rise of nation-states and the decline of empires and patrimonial kingdoms, the periodic outbursts of epidemics gradually attained more nationalist interpretations. Hence in the modern era, pandemics often triggered the growth of nationalist conspiracies. In these narratives the threatening Other was usually nationalised, and even traditional religious groups became reinterpreted as a threat to one’s national security. In recent times, new technologies and modes of communication have created space for the emergence of global conspiracy theories. The onset of Covid-19 has been associated with the dramatic expansion of such conspiracies. Some scholars have interpreted this as a reliable sign that nation-states and nationalisms have lost their dominance. However, this article shows that many global conspiracies in fact reinforce nationalist ideas and practices and, in this process, foster the perpetuation of national imagined communities.
Predictors of vegetable consumption in children and adolescents: analyses of the UK National Diet and Nutrition Survey (2008–2017)
Authors: Chawner Liam R. , Blundell-Birtill Pam , Hetherington Marion M. 
Published: October 2020

AbstractChildren’s vegetable consumption is generally below national recommendations in the UK. This study examined predictors of vegetable intake by children aged 1·5–18 years using counts and portion sizes derived from 4-d UK National Diet and Nutrition Survey food diaries. Data from 6548 children were examined using linear and logit multilevel models. Specifically, we examined whether demographic variables predicted vegetable consumption, whether environmental context influenced portion sizes of vegetables consumed and which food groups predicted the presence (or absence) of vegetables at an eating occasion (EO). Larger average daily intake of vegetables (g) was predicted by age, ethnicity, equivalised income, variety of vegetables eaten and average energy intake per d (R2 0·549). At a single EO, vegetables were consumed in larger portion sizes at home, with family members and at evening mealtimes (Conditional R2 0·308). Within EO, certain configurations of food groups such as carbohydrates and protein predicted higher odds of vegetables being present (OR 12·85, 95 % CI 9·42, 17·54), whereas foods high in fats, sugars and salt predicted a lower likelihood of vegetable presence (OR 0·03, 95 % CI 0·02, 0·04). Vegetables were rarely eaten alone without other food groups. These findings demonstrate that only one portion of vegetables was eaten per d (median) and this was consumed at a single EO, therefore falling below recommendations. Future research should investigate ways to encourage vegetable intake at times when vegetables are not regularly eaten, such as for breakfast and as snacks, whilst considering which other, potentially competing, foods are presented alongside vegetables.
Languages of othering and cultural hybridity. Transnational cultures of ageing in the context of return to the Azores
Authors: Sampaio Dora 
Published: October 2020

AbstractThis article foregrounds the role of migration and transnational cultural exchange in the (trans)formation of cultures of ageing. It argues that sustained emigration and return to the Azores archipelago have contributed to the transnational production of hybrid cultures of ageing. The paper suggests that understanding transnational cultures of ageing in the context of return requires a broader field of enquiry that considers return migrants’ discursive framings in tension with transnational and local contexts. Returnees’ accounts of ageing, produced in relation to transnational exchange and local interactions, emphasise three intersecting themes – health and the ageing body, ageing and care, and mindset and work ethic in later life – which reveal a cultural shift towards forms of active ageing. The discussion shows that new, hybrid lexicons of ageing are articulated through practices and languages of othering and negotiating that are conducive to unsettling social relations and economic contexts in the homeland.
Oxidative stress caused by a dysregulated Wnt/β-catenin signalling pathway is involved in abnormal placenta formation in pregnant mice with chronic fatigue syndrome
Authors: Zhao Hai , Zhang Jian , Qian Ning , Wu Shuguang , Wu Yanjun , Yao Gang 
Published: October 2020

SummaryChronic fatigue syndrome (CFS) is characterized by extreme fatigue and disabling symptoms. Women with CFS often have a high risk of gynaecological problems such as irregular menstruation, endometriosis and pelvic pain and sexual dysfunction. Our previous results have shown that, in pregnant mice, CFS significantly decreased the progestational hormone level in serum, as well as learning and memory, and the function of the hypothalamus–pituitary–gonadal axis. In addition, the F1 generation also suffered from congenital hypothyroidism. At present, there has been no report about placenta formation and embryonic development in pregnant mice with CFS. The aim of the present study was to investigate the influence of CFS on the morphology, oxidative stress and Wnt/β-catenin signalling pathway during placenta formation. In this study, we found that CFS decreased the number of implantation sites for blastocysts, and increased the number of absorbed, stillborn and malformed fetuses. The morphology and structure of the placenta were abnormal in pregnant mice with CFS. Further study found that the oxidative stress in serum, uterus and placenta was increased in pregnant mice with CFS, while the levels of antioxidase were decreased. CFS also inhibited the Wnt/β-catenin signalling pathway in the placenta. These results suggested that inhibition of the Wnt/β-catenin signalling pathway and enhanced oxidative stress play an important role in abnormal placentation in pregnant mice with CFS.
A flexible protocol for a systematic review of remote patient monitoring
Authors: Muller Ashley Elizabeth , Berg Rigmor C. 
Published: October 2020

Abstract

Background:
Norway is interested in implementing remote patient monitoring (RPM) within primary health services. This systematic review will first identify the types of RPM that are of interest to Norwegian health authorities, then synthesize the effects of RPM on clinical health and health service utilization outcomes among adults with chronic diseases.

Methods:
We will perform systematic literature searches in multiple databases, using RPM-related searches, such as telemedicine, telemonitoring, and eHealth. Based on what research exists, the review will be selected from a cascading menu of review types. Methodological quality will be assessed through appropriate checklists, while the quality of the evidence will be assessed through Grading of Recommendations Assessment, Development, and Evaluation.

Discussion:
This flexible protocol specifies the production of different possible types of reviews of RPM. It is anticipated that the results of the review will inform the development of effective RPM programs to the most appropriate chronic disease groups.
Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages
Authors: Xiang Wei , Shi Rongchen , Zhang Dapeng , Kang Xia , Zhang Lili , Yuan Jing , Zhang Xuan , Miao Hongming 
Published: October 2020

AbstractPeritoneal carcinomatosis (PC) of colorectal cancer (CRC) is a terminal phase of malignancy with no effective strategies for the prevention of this condition. Here we established PC models in mice by intraperitoneal engraftment of CRC cells and revealed an unexpected role for a high-fat diet (HFD) in preventing metastatic seeding in the visceral fat. Mechanistically, the HFD stimulated the activation of adipose tissue macrophages (ATMs) toward an M1-like phenotype and enhanced ATM tumor phagocytosis in a TLR4-dependent manner. Furthermore, the TLR4–Cxcl10 axis in ATMs promoted T cell recruitment, and M1-like macrophages stimulated T cell activation in tumor-seeded fats. The inhibitory effect of the HFD on tumor seeding was abolished with the ablation of macrophages, inactivation of T cells, or blockade of the TLR4–Cxcl10 axis in macrophages. Finally, we showed that a HFD and conventional chemotherapeutic agents (oxaliplatin or 5-fluorouracil) synergistically improved the survival of tumor-seeded mice. Collectively, our findings demonstrate that peritoneal seeding of CRC can be suppressed by short-term treatment with a HFD in the early phase, providing a novel concept for the management of these patients in the clinic.
A new strategy for membrane-based direct air capture
Authors: Fujikawa Shigenori , Selyanchyn Roman , Kunitake Toyoki 
Published: October 2020

AbstractDirect CO2 capture from the air, so-called direct air capture (DAC), has become inevitable to reduce the concentration of CO2 in the atmosphere. Current DAC technologies consider only sorbent-based systems. Recently, there have been reports that show ultrahigh CO2 permeances in gas separation membranes and thus membrane separation could be a potential new technology for DAC in addition to sorbent-based CO2 capture. The simulation of chemical processes has been well established and is commonly used for the development and performance assessment of industrial chemical processes. These simulations offer a credible assessment of the feasibility of membrane-based DAC (m-DAC). In this paper, we discuss the potential of m-DAC considering the state-of-the-art performance of organic polymer membranes. The multistage membrane separation process was employed in process simulation to estimate the energy requirements for m-DAC. Based on the analysis, we propose the target membrane separation performance required for m-DAC with competitive energy expenses. Finally, we discuss the direction of future membrane development for DAC.
Sarcopenia in hospitalized geriatric patients: insights into prevalence and associated parameters using new EWGSOP2 guidelines
Authors: Bertschi Dominic , Kiss Caroline M. , Beerli Nadine , Kressig Reto W. 
Published: October 2020

Abstract
Background
Data on prevalence of sarcopenia and its associated parameters in hospitalized geriatric patients are heterogeneous due to various definitions of the disease. The aim of this study was to determine the prevalence of sarcopenia using latest recommendations of the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and to investigate associated parameters in patients admitted to acute geriatrics and geriatric rehabilitation.

Methods
In this cross-sectional single-centre study including 305 hospitalized geriatric patients, handgrip strength (pneumatic hand dynamometer) and muscle quantity (body impedance analysis) were assessed. Probable sarcopenia was defined by low handgrip strength, and the diagnosis was confirmed when both handgrip strength and muscle quantity were below cut-off points. Furthermore, parameters of the geriatric baseline examination were analyzed for association with probable and confirmed sarcopenia using logistic regression models.

Results
Median age of the study population was 84.0 years, and 65.6% were female. The prevalence of probable sarcopenia was 24.6% (CI 19.8–29.4%), and the prevalence of confirmed sarcopenia was 22.6% (CI 17.9–27.3%). Low calf circumference, low body mass index, cognitive impairment and an increased risk of malnutrition were found to be associated with confirmed sarcopenia. In contrast, only cognitive impairment was positively associated with probable sarcopenia.

Conclusions
Sarcopenia is highly prevalent in geriatric inpatients, and multiple parameters were found to be associated with the disease. To reduce negative clinical outcomes, our findings support the need for routinely performed admission examinations for prompt diagnosis of sarcopenia, and a timely start of treatment in hospitalized geriatric patients.
Genetic architecture of left ventricular noncompaction in adults
Authors: Ross Samantha Barratt , Singer Emma S. , Driscoll Elizabeth , Nowak Natalie , Yeates Laura , Puranik Rajesh , Sy Raymond W. , Rajagopalan Sulekha , Barratt Alexandra , Ingles Jodie , Bagnall Richard D. , Semsarian Christopher 
Published: October 2020

AbstractThe genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults diagnosed with LVNC while undergoing screening in the context of a family history of cardiomyopathy were excluded. Clinical data for 35 unrelated patients diagnosed with LVNC at ≥18 years of age were retrospectively analyzed. Left ventricular (LV) dysfunction, electrocardiogram (ECG) abnormalities, cardiac malformations or syndromic features were identified in 25 patients; 10 patients had isolated LVNC in the absence of cardiac dysfunction or syndromic features. Exome sequencing was performed, and analysis using commercial panels targeted 193 nuclear and mitochondrial genes. Nucleotide variants in coding regions or in intron-exon boundaries with predicted impacts on splicing were assessed. Fifty-four rare variants were identified in 35 nuclear genes. Across all 35 LVNC patients, the clinically meaningful genetic diagnostic yield was 9% (3/35), with heterozygous likely pathogenic or pathogenic variants identified in the NKX2-5 and TBX5 genes encoding cardiac transcription factors. No pathogenic variants were identified in patients with isolated LVNC in the absence of cardiac dysfunction or syndromic features. In conclusion, the diagnostic yield of genetic testing in adult index patients with LVNC is low. Genetic testing is most beneficial in LVNC associated with other cardiac and syndromic features, in which it can facilitate correct diagnoses, and least useful in adults with only isolated LVNC without a family history. Cardiac transcription factors are important in the development of LVNC and should be included in genetic testing panels.
Jervell and Lange-Nielsen syndrome with novel KCNQ1 and additional gene mutations
Authors: Matsuda Shinichi , Ohnuki Yuko , Okami Mayuri , Ochiai Eriko , Yamada Shiro , Takahashi Kazumi , Osawa Motoki , Okami Kenji , Iida Masahiro , Mochizuki Hiroyuki 
Published: October 2020

AbstractWe encountered a boy with Jervell and Lange-Nielsen syndrome (JLNS) with compound heterozygous KCNQ1 mutations, maternal Trp248Phe and a novel paternal mutation, Leu347Arg. His father showed long QT (LQT) and arrhythmia. His mother was asymptomatic with no ECG abnormalities. The proband and his father had an additional mutation (SNTA1 Thr372Met), which is reportedly related to SIDS. These results suggest that multiple gene mutations influence the phenotype of KCNQ1 mutation-related arrhythmia.
Structural basis for activation of the growth hormone-releasing hormone receptor
Authors: Zhou Fulai , Zhang Huibing , Cong Zhaotong , Zhao Li-Hua , Zhou Qingtong , Mao Chunyou , Cheng Xi , Shen Dan-Dan , Cai Xiaoqing , Ma Cheng , Wang Yuzhe , Dai Antao , Zhou Yan , Sun Wen , Zhao Fenghui , Zhao Suwen , Jiang Hualiang , Jiang Yi , Yang Dehua , Eric Xu H. , Zhang Yan , Wang Ming-Wei 
Published: October 2020

AbstractGrowth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its binding to the cognate receptor (GHRHR). Malfunction in GHRHR signaling is associated with abnormal growth, making GHRHR an attractive therapeutic target against dwarfism (e.g., isolated growth hormone deficiency, IGHD), gigantism, lipodystrophy and certain cancers. Here, we report the cryo-electron microscopy (cryo-EM) structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein at 2.6 Å. This high-resolution structure reveals a characteristic hormone recognition pattern of GHRH by GHRHR, where the α-helical GHRH forms an extensive and continuous network of interactions involving all the extracellular loops (ECLs), all the transmembrane (TM) helices except TM4, and the extracellular domain (ECD) of GHRHR, especially the N-terminus of GHRH that engages a broad set of specific interactions with the receptor. Mutagenesis and molecular dynamics (MD) simulations uncover detailed mechanisms by which IGHD-causing mutations lead to the impairment of GHRHR function. Our findings provide insights into the molecular basis of peptide recognition and receptor activation, thereby facilitating the development of structure-based drug discovery and precision medicine.
Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
Authors: Raschetti Roberto , Vivanti Alexandre J. , Vauloup-Fellous Christelle , Loi Barbara , Benachi Alexandra , De Luca Daniele 
Published: October 2020

AbstractA number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.