bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing the public health voice in global decision-making on nutrition labelling
Authors: Thow Anne Marie , Jones Alexandra , Huckel Schneider Carmen , Labonté Ronald 
Published: January 2020

AbstractTo respond to the global noncommunicable disease (NCD) crisis, the Codex Alimentarius Commission (Codex), a multilateral United Nations body responsible for work on food standards, is developing global guidance for front of pack (FoP) nutrition labelling. Guidance from Codex regarding FoP nutrition labelling at the global level will almost certainly influence national policy making. This shift in Codex’s activities towards standards to address NCDs presents new risks for achievement of public health goals, as a result of the high level of industry involvement in this forum; there is a potential commercial conflict of interest held by manufacturers of products whose consumption could be discouraged by such guidance. In this Commentary, we examine the implications of Codex processes for developing robust global guidance on FoP nutrition labelling and identify opportunities to increase consideration of public health objectives. To date, there has been significantly higher representation of food industry compared to public health actors in Codex discussions on FoP nutrition labelling. Without a strong public health voice in Codex, the industry voice could dominate discussions on FoP nutrition labelling, such that subsequent global guidance prioritises future trade and profits over potential risks to public health. There is currently a critical window of opportunity for public health interests to be prioritised in this multisectoral international forum. The key public health priority for global guidance on FoP nutrition labelling is to ensure protection of policy space for national governments to implement strong and effective regulation, and allow scope for innovation. Public health actors can engage directly with Codex processes, at both the national and global level, and also need to raise awareness among domestic policy makers – including with Ministries of Agriculture and Industry, which often represent countries at Codex – regarding the importance and effectiveness of FoP labelling in NCD prevention. Increased engagement with Codex processes represents a tangible new opportunity to strengthen global governance for public health, and move towards improved coherence between trade policy and health protection goals.
LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway
Authors: Cheng Bo , Rong Aimei , Zhou Quanbo , Li Wenlu 
Published: January 2020

AbstractBackgroundLncRNA LINC00662 is closely related to the occurrence and development of cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth and metastasis and its molecular mechanism.MethodsCCK8, colony formation, transwell, scratch wound, TUNEL, flow cytometry, RT-PCR, western blotting and immunohistochemistry assays were used to detect the proliferation, apoptosis, invasion and migration of colon cancer cell and mRNA and protein expressions. Luciferase reporter and RNA pull down assays were used to detect the combination of LINC00662 and miR-340-5p or IL22 and the combination of miR-340-5p and CLDN8/IL22. Co-immunoprecipitation were used to detect the co-expression of CLDN8 and IL22 in colon cell lines. The targets of LINC00662 were predicated by Starbase v2.0. The target genes of miR-340-5p were predicated by miRDB and TargetScan. GO and KEGG enrichment analysis were performed by DAVID website.ResultsLINC00662 was up-regulation in colon cancer tissues and cell lines. Univariate Cox regression analysis showed that the LINC00662 expression level was related to the poor prognosis. LINC00662-WT and miR-340-5p mimics co-transfection depressed luciferase activity and IL22/CLDN8-WT and miR-340-5p inhibitors co-transfection memorably motivated luciferase activity. LINC00662 overexpression promoted cell proliferation, invasion and migration, and inhibited cell apoptosis in colon cancer. In vivo xenograft studies in nude mice manifested that LINC00662 overexpression prominently accelerate tumor growth. There was an opposite reaction in the biological functions of colon cells and tumor growth between LINC00662 overexpression and LINC00662 inhibition in vitro and in vivo. The functions of miR-340-5p mimics regulating the biological functions of colon cells and tumor growth were consistent with those of LINC00662 inhibition. CLDN8 and IL22, as target genes of miR-340-5p, reversed the functions of LINC00662 affecting the biological functions of colon cells and the protein levels of Bax, Bcl-2, XIAP, VEGF, MMP-2, E-cadherin and N-cadherin. Co-immunoprecipitation experiments indicated that CLDN8 directly interact with IL22 in colon cell lines. LINC00662 regulated CLDN8 and IL22 expressions and the activation of ERK signaling pathway via targeting miR-340-5p.ConclusionLINC00662 overexpression promoted the occurrence and development of colon cancer by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway.
Type II acquired cutis laxa associated with recurrent urticarial vasculitis: brief report
Authors: Nabatanzi Amelia , Da Siqi , Male Musa , Chen Siyuan , Huang Changzheng 
Published: January 2020

Abstract
Background
Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and autoimmune diseases. We present a rare case of acquired cutis laxa following a recurrent urticaria-like eruption in the absence of an autoimmune disease, neoplasm, drugs and or syndrome.

Case presentation
We report a case of a 45-year-old Chinese lady with a 1-year history of widespread pruritic urticarial eruption and a 6-month history of progressive skin wrinkling. On examination, the patient appeared older than her actual age, with apparent wrinkling on the mid-torso with generalized smooth, erythematous macules and wheals. A family history of similar conditions was absent. Biopsy revealed hypersensitivity and atrophy. Following the Food and Drug Administration (FDA) guidelines, we administered antihistamines, which relieved the itching, but her hyperpigmentation and cutis laxa never improved.

Conclusion
Our case shows that the decrease of elastic fibers may be associated with the infiltration of inflammatory cells in the dermis. This supports the hypothesis that chemical mediators may play a major role in the destruction of elastic fibers, thus causing cutis laxa. In addition, we advise practitioners to take a complete clinical and family history to determine if the condition is inherited or acquired.
CT and MR imaging of cystic renal lesions
Authors: Agnello Francesco , Albano Domenico , Micci Giuseppe , Di Buono Giuseppe , Agrusa Antonino , Salvaggio Giuseppe , Pardo Salvatore , Sparacia Gianvincenzo , Bartolotta Tommaso Vincenzo , Midiri Massimo , Lagalla Roberto , Galia Massimo 
Published: January 2020

AbstractCystic renal lesions are a common incidental finding on routinely imaging examinations. Although a benign simple cyst is usually easy to recognize, the same is not true for complex and multifocal cystic renal lesions, whose differential diagnosis includes both neoplastic and non-neoplastic conditions. In this review, we will show a series of cases in order to provide tips to identify benign cysts and differentiate them from malignant ones.
RETRACTED ARTICLE: Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway
Authors: Feng Yun , Wang Linlin , Ma Xiaoying , Yang Xiaotong , Don Ocholi , Chen Xiaoyan , Qu Jieming , Song Yuanlin 
Published: January 2020

Abstract
Background
ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-like peptide 1 (GLP-1) agonist, possesses anti-inflammatory and proliferation promotion functions, we proposed to probe the potential combinatory effect of hCMSCs and liraglutide on ALI.

Methods
We examined the time- and dose-dependent manner of GLP-1R, SPC, Ang-1, and FGF-10 with LPS via western blot and qRT-PCR. Western blot and chromatin immunoprecipitation assay detected the effects of liraglutide on GLP-1R, SPC, Ang-1, and FGF-10 through PKAc/β-catenin pathway and cAMP pathway. In the ALI animal model, we detected the effects of MSC and liraglutide combination on ALI symptoms by H&E staining, western blot, ELISA assays, calculating wet-to-dry ratio of the lung tissue, and counting neutrophils, leukocytes, and macrophages in mouse bronchoalveolar lavage fluid (BALF).

Results
The data demonstrated that LPS reduced hCMSC proliferation and GLP-1R, SPC, Ang-1, and FGF-10 levels in a dose- and time-dependent manner. Liraglutide significantly dampened the reduction of GLP-1R, SPC, Ang-1, and FGF-10 and reversed the effect of LPS on hCMSCs, which could be regulated by GLP-1R and its downstream cAMP/PKAc/β-catenin-TCF4 signaling. Combination of hCMSCs with liraglutide showed more therapeutic efficacy than liraglutide alone in reducing LPS-induced ALI in the animal model.

Conclusions
These results reveal that the combination of hCMSCs and liraglutide might be an effective strategy for ALI treatment.
Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
Authors: Wang Chen-Xi , Ge Xi-Yuan , Wang Ming-Yue , Ma Ting , Zhang Yu , Lin Ye 
Published: January 2020

Abstract
Background
Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation by stimulating the receptors on BMSCs, but the essential mediators of DA-induced osteogenic signaling remain unclear.

Methods
In this work, we evaluated the influence of both dopamine D1 and D2 receptor activation on BMSC osteogenic differentiation. Gene and protein expression of osteogenic-related markers were tested. The direct binding of transcriptional factor, Runx2, to those markers was also investigated. Additionally, cellular differentiation-associated signaling pathways were evaluated.

Results
We showed that the expression level of the D1 receptor on BMSCs increased during osteogenic differentiation. A D1 receptor agonist, similar to DA, induced the osteogenic differentiation of BMSCs, and this phenomenon was effectively inhibited by a D1 receptor antagonist or by D1 receptor knockdown. Furthermore, the suppression of protein kinase A (PKA), an important kinase downstream of the D1 receptor, successfully inhibited DA-induced BMSC osteogenic differentiation and decreased the phosphorylation of ERK1/2. Compared with P38, MAPK, and JNK, DA mainly induced the phosphorylation of ERK1/2 and led to the upregulation of Runx2 transcriptional activity, thus facilitating BMSC osteogenic differentiation. On the other hand, an ERK1/2 inhibitor could reverse these effects.

Conclusions
Taken together, these results suggest that ERK signaling may play an essential role in coordinating the DA-induced osteogenic differentiation of BMSCs by D1 receptor activation.
Multiple homoclinic solutions for p-Laplacian Hamiltonian systems with concave–convex nonlinearities
Authors: Wan Lili 
Published: January 2020

AbstractThe multiplicity of homoclinic solutions is obtained for a class of thep-Laplacian Hamiltonian systems$\frac{d}{dt}(|\dot{u}(t)|^{p-2}\dot{u}(t))-a(t)|u(t)|^{p-2}u(t)+ \nabla W(t,u(t))=0$ddt(|u˙(t)|p−2u˙(t))−a(t)|u(t)|p−2u(t)+∇W(t,u(t))=0via variational methods, where$a(t)$a(t)is neither coercive nor bounded necessarily and$W(t,u)$W(t,u)is under new concave–convex conditions. Recent results in the literature are generalized even for$p=2$p=2.
The Holocaust & (Bio-)Ethics Education: Setting the Context
Authors: Gallin Stacy , Bedzow Ira 
Published: January 2020

Holocaust education is important for learning how healthcare has been leveraged to influence social change in the past and how it can be used to advocate for ethical social change in the future. By understanding how medical professionals became the social and political leaders of Nazi Germany, today’s health professionals can learn how to avoid unethical politicization. By understanding how early twentieth century discourse on medico-social issues used terms and language that are similar, if not the same, as today’s debates, proponents of different sides of these debates can understand the troubling subtexts and potential consequences of their – and the opposing side’s – positions.
The Analysis of Reliability Factor’s Testing of An Academic Information System
Authors: Rofiah Habibatur , Arifin Hendra Dea , Muhsina Elvanisa Ayu , Mulyanto Agus 
Published: January 2020

Academic information system of STMIK El Rahma College is a software which has function to make academic access activities easier. The system has no good quality yet. For example, several menus are unable to be opened. Furthermore, the system has no error notification upon several menus. Hence testing software is necessitated to examine the reliability in operating of the system. McCall method has precision and detail which can be used to examine and assure the reliability of the academic information system of STMIK El Rahma. This research uses a testing procedure plan of software to obtain the reliability degree of the academic information system of STMIK El Rahma for SIMAK menu. The result of the reliability degree of the software is 49,29 %. It is obtained by several percentages such as 96% Accuracy, 0% Consistency, 62.96% Error Tolerance, 43,75% Modularity, and 43,75% Simplicity. The fivepercentages are divided by 5.
Rheological and Mechanical Gradient Properties of Polyurethane Elastomers for 3D-Printing with Reactive Additives
Authors: Wang Peng , Auhl Dietmar , Uhlmann Eckart , Gerlitzky Georg , Wagner Manfred H. 
Published: January 2020

AbstractPolyurethane (PU) elastomers with their broad range of strength and elasticity are ideal materials for additive manufacturing of shapes with gradients of mechanical properties. By adjusting the mixing ratio of different polyurethane reactants during 3D-printing it is possible to change the mechanical properties. However, to guarantee intra- and inter-layer adhesion, it is essential to know the reaction kinetics of the polyurethane reaction, and to be able to influence the reaction speed in a wide range. In this study, the effect of adding three different catalysts and two inhibitors to the reaction of polyurethane elastomers were studied by comparing the time of crossover points between storage and loss modulus G′ and G′′ from time sweep tests of small amplitude oscillatory shear at 30°C. The time of crossover points is reduced with the increasing amount of catalysts, but only the reaction time with one inhibitor is significantly delayed. The reaction time of 90% NCO group conversion calculated from the FTIR-spectrum also demonstrates the kinetics of samples with different catalysts. In addition, the relation between the conversion as determined from FTIR spectroscopy and the mechanical properties of the materials was established. Based on these results, it is possible to select optimized catalysts and inhibitors for polyurethane 3D-printing of materials with gradients of mechanical properties.
Primary mucinous adenocarcinoma of appendix invading urinary bladder with a fistula: a case report
Authors: Yang Jiwei , Wang Jianning , Men Tongyi , Zhang Xiaoming , Li Xianduo , Shen Bin , Zhou Ping 
Published: January 2020

AbstractAn adenocarcinoma of the appendix invading the urinary bladder, which is difficult to be diagnosed before the operation, is an extremely rare disease. Only a few cases have been reported. Here we reported a case of patient diagnosed with the mucinous adenocarcinoma of the appendix invading the urinary bladder. The case reported in this study was a 54-years old man who was admitted due to a 6-month history of intermittent episodes of irritative voiding symptoms of the bladder, and weight loss. The patient did not have any gastrointestinal symptoms. The physical examination, laboratory examination, cytology of the urine, computed tomography and cystoscopy were inconclusive. The partial cystectomy, subsequent exploratory laparotomy and intraoperative frozen analysis revealed the appendiceal mucinous adenocarcinoma with a fistula to the urinary bladder. The appendectomy and the right hemicolectomy with a ileocolic anastomosis, the lymphadenectomy and the partial cystectomy limited to the anterior wall was performed. Six months after operation, the patient was in a good health with no obvious discomfort, no recurrence or distant metastases. The recommended treatment for the adenocarcinoma of the appendix invading the bladder with a fistula formation is as follows: appendectomy, right hemicolectomy with ileocolic anastomosis, lymphadenectomy, partial cystectomy and intraperitoneal hyperthermic chemoperfusion.
Effect of He Qi San on DNA Methylation in Type 2 Diabetes Mellitus Patients with Phlegm-blood Stasis Syndrome
Authors: Shufang Chu , Yinan Zhou , Huilin Li , Hengxia Zhao , Deliang Liu , Xuemei Liu 
Published: January 2020

AbstractThis study was performed to elucidate the potential influence of He Qi San (HQS) on glucose and lipid metabolism in type 2 diabetes mellitus (T2DM) patients with phlegm-blood stasis syndrome (PBSS), and to determine DNA methylation changes. Sixty T2DM patients with PBSS were randomly divided into control and HQS groups. The control group received conventional treatments, and the HQS group received conventional treatments plus HQS. Glucose metabolism (FPG, 2hPG, FINS, and HbA1c) and lipid metabolism indexes (TG, TC and LDL-C) were determined. Genes with differential DNA methylation were subjected to GO and KEGG analyses. Glucose and lipid metabolism indexes in both groups were reduced, but were much more pronounced in the HQS group. Differential promoter CpG methylation regions were identified in 682 genes, including 426 genes with high-CpG promoters, 150 genes with intermediate CpG promoters, and 106 genes with low CpG promoters. Genes with differential DNA methylation were mainly enriched in the AMPK and insulin signaling pathways, terpenoid backbone biosynthesis, and renin secretion. We concluded that HQS remarkably improved indexes of glucose and lipid metabolism in T2DM patients with PBSS through regulating the DNA methylation of genes in the AMPK and insulin signaling pathways and terpenoid backbone biosynthesis.
Study on the Mechanism of Shugan Xiaozhi Fang on Cells with Non-alcoholic Fatty Liver Disease
Authors: Xing Yufeng , Zhang Chuantao , Zhai Fenfen , Zhou Tianran , Cui Xiang , Han Zhiyi , Peng Deti , Tong Guangdong 
Published: January 2020

AbstractCells with non-alcoholic fatty liver disease (NAFLD) were studied to determine the mechanism of liver deficiency via the AdipoR2-PPARa pathway. NAFLD cells were randomly divided into a normal control group, blank control group, model group, low dose group, medium dose group, and high dose group. The NAFLD models were established by incubating the cells with linoleic acid (LA) and palmitic acid (PA) (2:1) for 24 h. The test groups were incubated with different doses of Shugan Xiaozhi Fang extract. The pathological changes in cells that accumulated lipids were detected by Oil Red O staining. Malondialdehyde (MDA) and triglyceride (TG) levels were measured. The apoptosis of cells was evaluated by flow cytometry. The levels of AdipoR2, PPARa, CD36, acyl-CoA mRNA, and protein were confirmed by RT- PCR and Western blot. The results of the Oil Red O staining demonstrated that the NAFLD cell model was successfully established. Compared with the model group, the levels of TG and MDA in the groups that received low, medium, and high doses of Shugan Xiaozhi were significantly lower (P<0.01), and a dose effect was evident. In addition, the expression of AdipoR2, PPARa, CD36, acyl-CoA protein, and mRNA in the Shugan Xiaozhi-treated groups was upregulated. Furthermore, the levels of AdipoR2, PPAR, CD36, acyl-CoA protein, and mRNA in all drug treatment groups that were extracted from L-O2 normal human hepatocytes were significantly upregulated (P<0.01). Moreover, the factor pattern of HepG2 human liver carcinoma cells was similar to that of L-O2. The levels of AdipoR, CD36, acyl-CoA, and AdipoR mRNA in the HepG2 low group were increased (P<0.05). AdipoR, PPAR, CD36, and acyl-CoA protein levels and AdipoR mRNA expression were significantly increased in the intermediate dose group and high dose group (P<0.01). Shugan Xiaozhi Fang attenuates hepatic lipid deposition in NAFLD induced by incubating with LA and PA for 24 h, which is associated with the activation of the AdipoR2-PPARα pathway.
Stativity in the Causative Alternation? New Questions and a New Variant
Authors: Rasia Maria Eugenia Mangialavori 
Published: January 2020

AbstractThis paper discusses whether capacity to license an internal argument and eventivity are default properties of so-called change-of-state verbs.I draw attention to the claim that, in certain languages, the causative-inchoative alternation extends to a third, external-argument-only variant with stative behavior. Productivity and systematicity raise a host of problems for current generalizations on the Causative Alternation and change-of-state verbs for various reasons, starting from the long-held claim that unique arguments of change-of-state verbs are by default internal. Insofar as the causative component is independently realized in a noneventive, nonepisodic frame, this variant challenges (a) a widely agreed rule of event composition, wherebycause, if present, causally implicatesprocess; (b) the claim that cause(r) interpretation of the external argument is a byproduct of transitivization. The present discussion: (a) brings out a crosslanguage contrast bearing on default (cause/undergoer) interpretation of unique arguments in equipollent alternations; (b) provides new empirical data supporting the stativity of the (causative) outer v head; (c) substantiates important predictions in the literature (e.g. that verbs of causation should have stative readings; that external-argument-only variants of Object-Experiencer verbs should be found); (d) captures further verb classes allowing the alternation; and (e) shows crucial contrasts with other transitive-(in/a)transitive alternations involving null/arb objects. Aspect and determination of different (a)atransitivity alternations are central throughout.
DESPLIEGUE SOCIAL DE LA ESPIRITUALIDAD EN AMÉRICA LATINA
Authors: Costadoat Jorge 
Published: January 2020

En la Iglesia Latinoamericana post-conciliar la experiencia de Dios ha experimentado un desarrollo y una ampliación extraordinaria. Este artículo trata de dos despliegues. En la primera parte se describe el paso de una noción de espiritualidad centrada en la búsqueda de la santidad personal a otra centrada en el seguimiento de Cristo. En la segunda parte se explicará cómo la apertura de la Iglesia al discernimiento de los signos de los tiempos, actividad espiritual y eclesial, ha obligado a los cristianos a integrar en su experiencia de Dios un llamado a solidarizar con la liberación del prójimo en el sentido más amplio de la palabra. ***DESDOBRAMENTO SOCIAL DA ESPIRITUALIDADE NA AMÉRICA LATINA***Na Igreja latino-americana pós-conciliar, a experiência de Deus experimentou um extraordinário desenvolvimento e expansão. Este artigo trata sobre dois desdobramentos. Na primeira parte, descreve-se a passagem de uma noção de espiritualidade centrada na busca de santidade pessoal para outra focada no seguimento de Cristo. Na segunda parte, será explicado como a abertura da Igreja ao discernimento dos sinais dos tempos, atividade espiritual e eclesial, forçou os cristãos a integrar em sua experiência de Deus um chamado à solidariedade para com a libertação do próximo, no sentido mais amplo da palavra.