bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological stress, cardiac symptoms, and cardiovascular risk in women with suspected ischaemia but no obstructive coronary disease
Authors: Gomez Mayra A. , Merz Noel Bairey , Eastwood Jo‐Ann , Pepine Carl J. , Handberg Eileen M. , Bittner Vera , Mehta Puja K. , Krantz David S. , Vaccarino Viola , Eteiba Wafia , Rutledge Thomas 
Published: January 2020

AbstractThis paper evaluated cross‐sectional relationships between psychological stress and coronary artery disease (CAD) risk among women with suspected ischaemia and no obstructive coronary artery disease (INOCA). Between 1996 and 2000, 551 women with INOCA were enrolled in the Women's Ischemia Syndrome Evaluation (WISE) cohort from four U.S. institutions. Between 2009 and 2012, 376 women with INOCA were recruited from two U.S. institutions for an independent cohort study titled WISE‐Coronary Vascular Dysfunction (WISE‐CVD). Participants underwent coronary angiography and testing for CAD symptoms and risk factors at baseline. Psychological stress was assessed in the form of home/work stress in WISE and home/work stress and financial stress in WISE‐CVD. Results showed that home/work stress predicted greater depression, functional impairment, CAD symptoms, and lower self‐rated health in WISE but was inconsistent as a predictor in WISE‐CVD. In contrast, >60% of WISE‐CVD women reported moderate or severe financial stress. Financial stress levels predicted more CAD risk factors and cardiac symptoms, poorer self‐rated health, and greater depression and functional impairment. Among women with INOCA, psychological stress was associated with CAD symptoms and CAD risk factors. The prevalence and predictive value of psychological stress in this population supports the inclusion of stress measures in future CAD research.
An Appreciation of Metaphors in Management Consulting from the Conceptual Lens of Holistic Flexibility
Authors: Chowdhury Rajneesh 
Published: January 2020

AbstractMetaphors are popular in human interaction as a means to make relevant associations, convey complex ideas, and even dramatize reality or introduce humour in conversations. Metaphors, if leveraged effectively, can be a powerful tool for management consultants in their client engagement process. Chosen with a sensitive and empathetic rationale, metaphors can not only help fathom highly complex problem situations, they can also bring in an element of light‐heartedness in consulting conversations that may otherwise be stale and unexciting. Metaphorical associations can enable informality, trust, and long‐term engagement between consultants and their clients. This paper presents a first person narrative of how the author has used metaphors as a tool for creative consulting. A reflection is provided on how the experiences narrated in this paper align with the conceptual lens of holistic flexibility introduced by Rajneesh Chowdhury in his latest book on systems thinking for management consultants in 2019.
Design, development and optimization of new high performance thin‐layer chromatography method for quantitation of Retapamulin in pharmaceutical formulation: Application of design of experiment
Authors: Patel Rashmin , Patel Nishant , Patel Mrunali 
Published: January 2020

AbstractThe objective of the present study was to design, develop and optimize Design of Experiments supported high performance thin‐layer chromatography method for quantitative estimation of Retapamulin in marketed cream and microemulsion formulations. Design of Experiments help to identify and understand the effect of important factors on response with minimum experimental run in developing robust method. To optimize chromatographic conditions and to study their effects on separation of Retapamulin, Box–Behnken experimental design was selected. Experimental conditions with desirability 1 were selected which gave the optimal composition of methanol in mobile phase along with ethyl acetate: ammonia, development distance of 70 millimeter and chamber saturation time of 22 minutes. Retapamulin was well separated with retardation factor value 0.60 from excipients of marketed cream formulation on high performance thin‐layer chromatography plate using optimized chromatographic conditions. The optimized method was validated and statistical analysis proved that the method is specific, sensitive, accurate and precise. A new high performance thin‐layer chromatography has been successfully designed, developed, optimized and validated for quantification of Retapamulin in cream formulation using Box–Behnken design. The proposed high performance thin‐layer chromatography method is easy, convenient, reliable and accurate for the routine analysis of Retapamulin in marketed cream and microemulsion formulations.
Proposals for a practical calibration method for mechanical torque measurement on the wind turbine drive train under test on a test bench
Authors: Zhang Hongkun , Wenske Jan , Reuter Andreas , Neshati Mohsen 
Published: January 2020

AbstractThe mechanical torque input into the wind turbine drive train is a very useful measurement for tests performed on a test bench. To ensure the accuracy and the reliability, an accurate calibration of the torque measurement must be carried out and repeated within a certain period of time. However, owing to the high torque level and large structure size, such a calibration is both expensive and time consuming. To overcome this challenge, a new calibration method is proposed here. The method is based on the electrical power measurement, where a high level of accuracy is much easier to achieve. With the help of a special test process, a relationship between the torque‐measuring signal and the electrical power can be established. The process comprises two tests with the drive train running in different operating modes. The calibration is possible by carrying out the same test process on several different torque levels. Detailed uncertainty analysis of the method is presented, whereby the uncertainty can be calculated by means of matrix operation and also numerically. As a demonstration, the implementation of the method on a test bench drive train that contains two 5‐MW motors in tandem with the motors operating in a back‐to‐back configuration is also presented. Finally, some variations on the method and possible ways of achieving better accuracy are discussed.
Application of mild pulsed electric fields on starter culture accelerates yogurt fermentation
Authors: Chanos Panagiotis , Warncke Malou C. , Ehrmann Matthias A. , Hertel Christian 
Published: January 2020

AbstractThe goal of this work was to investigate the influence of pulsed electric fields (PEF) operational parameters on a mixture of Streptococcus thermophilus DIL 5218 and Lactobacillus delbrueckii subsp. bulgaricus DSMZ 20081T with regards to the culture’s acidification capability in reconstituted skim milk medium. We investigated the effects of field strength, pulse frequency and total number of pulses by use of design of experiments and a two-level full factorial design. The responses were the cell counts of the two microorganisms after PEF application, the pH lag phase λpH, the maximum pH change rate µmax, the maximum pH change and the oxidation/reduction potential (ORP). The application of PEF on the mixed culture accelerated the acidification of milk by an average of 12 min in an approx. 160 min lasting control λpH. In contrast the maximum pH change rate µmax and the maximum pH change decreased slightly in fermentations with PEF-treated cultures. Furthermore, a significantly faster decrease of the oxidation/reduction potential (ORP) already within the first 30 min and a lower final ORP was observed in milk fermented with PEF-treated culture. The total number of pulses applied was the most influencing factor in most of the responses measured. We hypothesized that the reason for the enhanced performance of the PEF-treated culture was a combination of an oxidative stress response of S. thermophilus DIL 5218 and an enhanced proteolytic phenotype in L. delbrueckii subsp. bulgaricus DSMZ 20081T.
Magnetic Skyrmions at Critical Coupling
Authors: Barton-Singer Bruno , Ross Calum , Schroers Bernd J. 
Published: January 2020

AbstractWe introduce a family of models for magnetic skyrmions in the plane for which infinitely many solutions can be given explicitly. The energy defining the models is bounded below by a linear combination of degree and total vortex strength, and the configurations attaining the bound satisfy a first order Bogomol’nyi equation. We give explicit solutions which depend on an arbitrary holomorphic function. The simplest solutions are the basic Bloch and Néel skyrmions, but we also exhibit distorted skyrmions and anti-skyrmions as well as line defects and configurations consisting of skyrmions and anti-skyrmions.
Effective long-term treatment with incobotulinumtoxin (Xeomin®) without neutralizing antibody induction: a monocentric, cross-sectional study
Authors: Hefter Harald , Brauns Raphaela , Ürer Beyza , Rosenthal Dietmar , Albrecht Philipp 
Published: January 2020

Abstract
Background
Among the spectrum of licensed botulinum neurotoxin preparations incobotulinumtoxin (incoBoNT/A; Xeomin®) is the only one which does not contain complex proteins. Therefore, incoBoNT/A has been suggested to have a low antigenicity, but precise estimations on incidence and prevalence of neutralizing antibody formation during long-term treatment are outstanding so far.

Methods
For the present cross-sectional study, 59 patients having exclusively been treated with incoBoNT/A (mono group) and 32 patients having been treated with other BoNT/A preparations less than nine times and who were then switched to at least 14 sessions of incoBoNT/A treatment (switch group) were recruited from one botulinum toxin outpatient clinic. Side effects and doses were extracted from the charts, and the efficacy of treatment was assessed by the patients using a visual analogue scale (0–100). The prevalence of neutralizing antibodies was tested by means of the mouse hemi-diaphragm assay (MHDA).

Findings
None of the patients in the mono and only two in the switch group had a positive MHDA-test. Across all indications and patients, mean improvement exceeded 67%. Improvement did not depend on age at onset, sex, change of dose or duration of treatment, but on disease entity. In patients with cervical dystonia, improvement was about the same in the mono and switch subgroup, but the last dose was different.

Conclusions
The present study confirms the low antigenicity of incoBoNT/A, which has immediate consequences for patient management, and the use of higher doses and shorter durations of reinjection intervals in botulinum toxin therapy.
Biofilm cultivation of marine dinoflagellates under different temperatures and nitrogen regimes enhances DHA productivity
Authors: Tsirigoti Amerssa , Tzovenis I. , Koutsaviti A. , Economou-Amilli A. , Ioannou E. , Melkonian M. 
Published: January 2020

AbstractDinoflagellates contain large amounts of omega-3 fatty acids, including the nutritionally important docosahexaenoic acid (DHA). However, their cultivation in suspensions is characterized by low growth rates. Twin-layer porous substrate photobioreactors (TL-PSBRs) have been shown to support growth of different microalgal species, including the robust dinoflagellate Symbiodinium voratum. In the present study, the potential of cultivating marine autotrophic dinoflagellate species in a TL-PSBR for DHA production was explored. Based on initial screening experiments, two Symbiodinium species with high biomass and DHA productivities were selected: the symbiotic Symbiodinium microadriaticum CCAC 2475 B and the free-living Symbiodinium voratum CCAC 3869 B. The effects of three different temperatures (17, 22 and 27 °C) and nitrogen regimes (nitrate, ammonium and nitrogen-free) on biomass growth, total lipid accumulation and fatty acid methyl esters (FAMEs) content, with emphasis on DHA, were evaluated. The two lower temperatures (17 and 22 °C) enhanced growth and total lipid accumulation of S. microadriaticum CCAC 2475 B and S. voratum CCAC 3869 B. Cultivation at 22 °C and nitrogen limitation led to a significant positive effect on DHA productivity. Symbiodinium. microadriaticum CCAC 2475 B reached a DHA productivity of 145.4 mg m−2 day−1 and DHA content in the dry biomass of 2% (w/w) after 4 days of nitrogen depletion. The results of the present study demonstrated that autotrophic dinoflagellates, when cultivated on a TL-PSBR, produce comparable amounts of lipids and fatty acids to other commercially used microalgal species including the valuable DHA.
Dynamical Gibbs–Non-Gibbs Transitions in Lattice Widom–Rowlinson Models with Hard-Core and Soft-Core Interactions
Authors: Kissel Sascha , Külske Christof 
Published: January 2020

AbstractWe consider the Widom–Rowlinson model on the lattice $${\mathbb {Z}}^d$$Zd in two versions, comparing the cases of a hard-core repulsion and of a soft-core repulsion between particles carrying opposite signs. For both versions we investigate their dynamical Gibbs–non-Gibbs transitions under an independent stochastic symmetric spin-flip dynamics. While both models have a similar phase transition in the high-intensity regime in equilibrium, we show that they behave differently under time-evolution: the time-evolved soft-core model is Gibbs for small times and loses the Gibbs property for large enough times. By contrast, the time-evolved hard-core model loses the Gibbs property immediately, and for asymmetric intensities, shows a transition back to the Gibbsian regime at a sharp transition time.
Die gesundheitsförderliche Selbstführungskompetenz – das Stärken- und Ressourcentraining
Authors: Krick Annika , Felfe Jörg 
Published: January 2020

ZusammenfassungDas Stärken- und Ressourcentraining bietet eine Möglichkeit, die gesundheitsförderliche Selbstführungskompetenz zu stärken. Eine wissenschaftliche Evaluation des Trainings zeigt, dass es auf positive Resonanz stößt und wichtige Anregungen liefert, um Ressourcen im Arbeitsalltag zu fördern. Neben der Verbesserung von subjektiven Erfolgskriterien wie Achtsamkeit und gesundheitsförderlicher Selbstführung konnten auch auf physiologischer Ebene positive Effekte gezeigt werden. Für die Nachhaltigkeit wurde zudem eine Train-the-Trainer-Schulung konzipiert und erfolgreich evaluiert.
SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming
Authors: Li Yan , Zhao Zhenhui , Liu Wei , Li Xun 
Published: January 2020

AbstractCancer-associated fibroblasts (CAFs) are important ingredient in tumor microenvironment. The dynamic interplay between CAFs and cancer cells plays essential roles during tumor development and progression. However, the mechanisms of intercellular communication between CAFs and cancer cells remain largely unknown. We characterized exosomes secreted from breast cancer patient-derived CAFs by transmission electron microscopy. The expression of SNHG3, miR-330-5p, and PKM (Pyruvate Kinase M1/M2) was examined by real-time QPCR and immunoblot. The function of SNHG3 on the growth and metabolism of tumor cells was used by CCK8 and mitochondrial oxygen consumption assays. The binding between SNHG3, miR-330-5p, and PKM was examined by dual luciferase reporter assays. Orthotopical xenograft of breast tumor experiments was performed to determine the function of SNHG3 in vivo. We demonstrated that exosomes secreted from CAFs reprogram the metabolic pathways after tumor cells uptake the exosomes. CAF-secreted exosomal lncRNA SNHG3 served as a molecular sponge for miR-330-5p in breast cancer cells. Moreover, PKM could be targeted by miR-330-5p and was controlled by SNHG3 in breast cancer cells. Mechanistically, SNHG3 knockdown in CAF-secreted exosomes suppressed glycolysis metabolism and cell proliferation by the increase of miR-330-5p and decrease of PKM expression in tumor cells. SNHG3 functions as a miR-330-5p sponge to positively regulate PKM expression, inhibit mitochondrial oxidative phosphorylation, increase glycolysis carboxylation, and enhance breast tumor cell proliferation. Overall, SNHG3 could play a major role in the development and progression of breast cancer and support the therapeutic potential of targeting communication between cancer cells and tumor microenvironment.
Data storage and data re-use in taxonomy—the need for improved storage and accessibility of heterogeneous data
Authors: Gemeinholzer Birgit , Vences Miguel , Beszteri Bank , Bruy Teddy , Felden Janine , Kostadinov Ivaylo , Miralles Aurélien , Nattkemper Tim W. , Printzen Christian , Renz Jasmin , Rybalka Nataliya , Schuster Tanja , Weibulat Tanja , Wilke Thomas , Renner Susanne S. 
Published: January 2020

AbstractThe ability to rapidly generate and share molecular, visual, and acoustic data, and to compare them with existing information, and thereby to detect and name biological entities is fundamentally changing our understanding of evolutionary relationships among organisms and is also impacting taxonomy. Harnessing taxonomic data for rapid, automated species identification by machine learning tools or DNA metabarcoding techniques has great potential but will require their review, accessible storage, comprehensive comparison, and integration with prior knowledge and information. Currently, data production, management, and sharing in taxonomic studies are not keeping pace with these needs. Indeed, a survey of recent taxonomic publications provides evidence that few species descriptions in zoology and botany incorporate DNA sequence data. The use of modern high-throughput (-omics) data is so far the exception in alpha-taxonomy, although they are easily stored in GenBank and similar databases. By contrast, for the more routinely used image data, the problem is that they are rarely made available in openly accessible repositories. Improved sharing and re-using of both types of data requires institutions that maintain long-term data storage and capacity with workable, user-friendly but highly automated pipelines. Top priority should be given to standardization and pipeline development for the easy submission and storage of machine-readable data (e.g., images, audio files, videos, tables of measurements). The taxonomic community in Germany and the German Federation for Biological Data are researching options for a higher level of automation, improved linking among data submission and storage platforms, and for making existing taxonomic information more readily accessible.
Characterization and frequency analysis of flooding solid flow in semi-arid zone: case of Mekerra catchment in the north-west of Algeria
Authors: Diaf M. , Hazzab A. , Yahiaoui A. , Belkendil A. 
Published: January 2020

AbstractIn this study, we evaluate the soil erosion and solid transport in the oued Mekerra watershed in north-west Algeria. The study area is subject to a semi-arid climate characterized by irregular rainfall and showers, which are often accompanied by significant floods. These floods of large volumes transport large amounts of solid input to the Sarno dam, which is in the outlet of oued Mekerra. Therefore, the water storage capacity of this dam is gradually decreasing, and it might reach the volume of dead water. For this study, we utilized the hydrometric database provided by the National Agency of Water Resources (ANRH). The operating period was 24 years, from 1988 to 2012. This period was extended by classic regression to 65 years, which allowed extracting a series of annual maximum instantaneous flow rates (QIXA) and subsequently quantified the sediment yield during floods. The specific degradation mean created by the 11 floods was quite high, in the order of 20 t km2 year−1. The highest value of solid contribution was observed during the floods of October 2000 (250,000 t), and the value of liquid contribution was 7,151,608 m3. The extracted results from the analysis of the graphs of concentration as a function of the liquid flow (C = f′(Ql)) showed four types of hysteresis curves: clockwise loop, counterclockwise loop, shape of eight, and straight line curve. Class II (clockwise loop) was the dominant class in the four events, namely the floods that occurred on 09/22/1992, 09/21/1998, 09/27/1999, and the 08/24/2002. From these results, the water resource sector managers could formulate various methods for protection from floods and against the risk of sedimentation in storage structures.
Perovskite-Inspired Lead-Free Ag2BiI5 for Self-Powered NIR-Blind Visible Light Photodetection
Authors: Pecunia Vincenzo , Yuan Yue , Zhao Jing , Xia Kai , Wang Yan , Duhm Steffen , Portilla Luis , Li Fengzhu 
Published: January 2020

AbstractIn recent years, solution-processible semiconductors with perovskite or perovskite-inspired structures have been extensively investigated for optoelectronic applications. In particular, silver–bismuth–halides have been identified as especially promising because of their bulk properties and lack of heavily toxic elements. This study investigates the potential of Ag2BiI5 for near-infrared (NIR)-blind visible light photodetection, which is critical to emerging applications (e.g., wearable optoelectronics and the Internet of Things). Self-powered photodetectors were realized and provided a near-constant ≈ 100 mA W−1 responsivity through the visible, a NIR rejection ratio of > 250, a long-wavelength responsivity onset matching standard colorimetric functions, and a linear photoresponse of > 5 orders of magnitude. The optoelectronic characterization of Ag2BiI5 photodetectors additionally revealed consistency with one-center models and the role of the carrier collection distance in self-powered mode. This study provides a positive outlook of Ag2BiI5 toward emerging applications on low-cost and low-power NIR-blind visible light photodetector.
The people problem: how cyber security's weakest link can become a formidable asset
Authors: Fielding Jon 
Published: January 2020

The European General Data Protection Regulation (GDPR) finally began to bare its teeth last summer, with British Airways and the Marriott hotel chain both being hit with massive fines of £183m and £99.2m respectively for breaching the rules. 1, 2 Organisations saw that the Information Commissioner's Office (ICO) meant business when it came to applying its new powers, and this appears to have helped trigger a new wave of investment in cyber security. While the prospect of major fines has woken boardrooms up to the importance of cyber risk management, it has not necessarily led to money being spent in the right areas. The insider threat has increased as working practices have evolved and new technologies have been adopted. Collaboration platforms, cloud services, smart devices and mobile apps all represent varying forms of cyber risk. To tackle this effectively requires a mix of technical and process-driven measures, says Jon Fielding of Apricorn.
Anne Conway as a Priority Monist: A Reply to Gordon-Roth
Authors: THOMAS EMILY 
Published: January 2020

AbstractFor early modern metaphysician Anne Conway, the world comprises creatures. In some sense, Conway is a monist about creatures: all creatures are one. Yet, as Jessica Gordon-Roth (2018) has astutely pointed out, that monism can be understood in very different ways. One might read Conway as an ‘existence pluralist’: creatures are all composed of the same type of substance, but many substances exist. Alternatively, one might read Conway as an ‘existence monist’: there is only one created substance. Gordon-Roth has done the scholarship a great favor by illuminating these issues in Conway. However, this article takes issue with Gordon-Roth's further view that Conway ‘oscillates’ between the extremes of existence pluralism and monism. In its place, I argue we should read Conway as a priority monist: the whole of creation is ontologically prior to its parts.