bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of Clinical Pathways Can Reduce Drug Spend Within the Oncology Care Model
Authors: Hertler Andrew , Chau Sang , Khetarpal Rani , Bassin Ed , Dang Jeff , Koppel Daniel , Damarla Vijay , Wade James 
Published: March 2020

PURPOSE: Reducing drug spend is one of the greatest challenges for practices participating in the Oncology Care Model (OCM). Evidence-based clinical pathways have the potential to decrease drug spend while maintaining clinical outcomes consistent with published evidence. The goal of this study was to determine whether voluntary use of clinical pathways by a practice can maximize OCM episodic cost savings. METHODS AND MATERIALS: A community oncology practice used evidence-based clinical pathways for OCM-attributed patients. All treatment plans were submitted to the pathway vendor in real time for clinical pathway adherence measurement. Analysis was conducted before implementation and on an ongoing daily and weekly basis to identify cases in which higher cost drugs or regimens were ordered. A clinical data governance committee met biweekly to review clinical pathway performance metrics and drug utilization. RESULTS: From quarter 1 of 2017 to quarter 1 of 2019, the median drug spend increased less rapidly for Cancer Care Specialists of Illinois (CCSI; 18.6%) compared with OCM (34.4%). Furthermore, the percent difference in drug spend for CCSI relative to OCM decreased from 13.5% to 0.1% ( P < .001). Each quarter, there was approximately a 1.7% decrease (95% CI, 1.0% to 2.4%) in drug spend for CCSI relative to OCM. Additional analyses found that, over a 15-month period (October 2017 through December 2019), CCSI achieved an increase in pathway adherence from 69% to 81%. CONCLUSION: Reduction in drug spend is possible within a value-based care model, using evidence-based clinical pathways.
Quantifying the Mitigating Effects of Whole-Breast Radiotherapy and Systemic Treatments on Regional Recurrence Incidence Among Breast Cancer Patients
Authors: van Steenhoven Julia E. C. , Kuijer Anne , van Maaren Marissa C. , Roos Marleen , Elias Sjoerd G. , van Diest Paul J. , Siesling Sabine , Smidt Marjolein L. , Boersma Liesbeth J. , van Dalen Thijs 
Published: March 2020

Abstract
Background
Despite the potential for residual lymph node metastases after a negative or positive sentinel lymph node biopsy (SLNB), breast cancer patients rarely experience regional recurrences (RRs). This study aimed to quantify the effects of nonsurgical treatments on RR incidence among SLNB-negative (SLNB N0) breast cancer patients.

Methods
All primary SLNB N0-staged breast cancer patients with a diagnosis between 2005 and 2008 and 5-year follow-up data on recurrences were selected from the Netherlands Cancer Registry. The cumulative incidence function (CIF) for RR was calculated as the first event at 5 years, taking into account any other first-event (local or distant recurrence, contralateral breast cancer, or death) as competing risk. Cox regression analysis was used to model the cause-specific hazard of RR developing as the first event to quantify the effect of adjuvant systemic therapy and whole-breast radiotherapy (RT) on RR incidence at 5 years.

Results
The study included 13,512 patients. Of these patients, 162 experienced an RR. The CIF of RR at 5 years was 1.3% (95% confidence interval [CI], 1.1–1.5%), whereas the CIFs for death and other events were 4.4% and 9.5%, respectively. Cox regression analysis showed hazard ratios (HRs) of 0.46 (95% CI 0.33–0.64), 0.31 (95% CI 0.18–0.55), and 0.40 (95% CI 0.24–0.67) respectively for patients treated by RT as a routine part of breast-conserving therapy (BCT), chemotherapy, and hormonal therapy.

Conclusion
RT as routine part of BCT, chemotherapy, and hormonal therapy independently exerted a mitigating effect on the risk for the development of RR. The three methods at least halved the risk.
Casein Ingestion Does Not Increase Muscle Connective Tissue Protein Synthesis Rates
Authors: TROMMELEN JORN , HOLWERDA ANDREW M. , SENDEN JOAN M. , GOESSENS JOY P. B. , VAN KRANENBURG JANNEAU , GIJSEN ANNEMIE P. , VERDIJK LEX B. , VAN LOON LUC J. C. 
Published: March 2020

ABSTRACT

Purpose
This study aimed to assess the effect of dietary protein ingestion on intramuscular connective tissue protein synthesis rates during overnight recovery from a single bout of resistance exercise.

Methods
Thirty-six healthy, young males were randomly assigned to one of three treatments. One group ingested 30 g intrinsically L-[1-13C]-phenylalanine-labeled casein protein before sleep (PRO, n = 12). The other two groups performed a bout of resistance exercise in the evening and ingested either placebo (EX, n = 12) or 30 g intrinsically L-[1-13C]-phenylalanine-labeled casein protein before sleep (EX + PRO, n = 12). Continuous intravenous infusions of L-[ring-2H5]-phenylalanine and L-[1-13C]-leucine were applied, and blood and muscle tissue samples were collected to assess connective tissue protein synthesis rates and dietary protein-derived amino acid incorporation in the connective tissue protein fraction.

Results
Resistance exercise resulted in higher connective tissue protein synthesis rates when compared with rest (0.086 ± 0.017%·h−1 [EX] and 0.080 ± 0.019%·h−1 [EX + PRO] vs 0.059 ± 0.016%·h−1 [PRO]; P < 0.05). Postexercise casein protein ingestion did not result in higher connective tissue protein synthesis rates when compared with postexercise placebo ingestion (P = 1.00). Dietary protein-derived amino acids were incorporated into the connective tissue protein fraction at rest, and to a greater extent during recovery from exercise (P = 0.002).

Conclusion
Resistance exercise increases intramuscular connective tissue protein synthesis rates during overnight sleep, with no further effect of postexercise protein ingestion. However, dietary protein-derived amino acids are being used as precursors to support de novo connective tissue protein synthesis.
<strong><em>Physoglossus</em>: A new ground beetle genus of the enigmatic tribe Physocrotaphini Chaudoir, 1862 (Carabidae: Anthiinae) from the Western Ghats, a global hotspot of Biodiversity in south west India</strong>
Authors: SV AKHIL , SABU THOMAS K. 
Published: March 2020

A new genus of enigmatic tribe Physocrotaphini, Physoglossus gen. nov., with a new species Ph. devagiriensis sp. nov. from a dry deciduous forest in the rain shadow belt of the south Western Ghats in south west India is described. Presence of mentum with bifid median tooth and large oval depression with dense patch of filamentous setae on 2nd and 3rd male sternites makes it intermediate to the Physocrotaphini genera, Pogonoglossus, Foveocrotaphus and Physocrotaphus. Key words: new ground beetle species, Anthiinae, the Western Ghats, India
Eating behavior affects cardio-metabolic risk in high school teenagers in a developing country
Authors: Suhadi Rita , Hendra Phebe , Virginia Dita Maria , Setiawan Christianus Heru 
Published: March 2020

BACKGROUND Modernization negatively changes lifestyle, characterized by excessive eating and reduced energy consumption, and concurrently increases the cardiometabolic risk. This study was aimed to evaluate the association between eating behavior and cardio-metabolic risk factors including body mass index (BMI) in percentile, blood pressure (BP) in percentile, waist circumference, and heart rate in total subjects and gender sub-groups.
METHODS This analytical cross-sectional study was done from July to November 2018. High schools in four provinces of Indonesia and students were selected using purposive sampling. Subjects’ profiles were collected from interview and cardio-metabolic parameters were measured at the study sites. Data were analyzed with chi-square and independent t-test.
RESULTS Subjects who were overweight/obese and had high BP accounted for 27.1% and 9.3–12.0% of the total subjects (n = 768), respectively. Subjects who having breakfast tended to have lower BMI (p = 0.006), and the lower consumption of western meals had lower heart rate (p = 0.02). Male subjects had more meal frequency and had less quantity of snacks than female subjects (p<0.001). Male subjects with routine intake of vegetables had low heart rate (p = 0.03). Female subjects with routine breakfast had better BMI (p<0.001), and lower diastolic BP (p = 0.004) and waist circumference (p = 0.02), whereas those who consumed Western meals had higher heart rate (p = 0.046) and waist circumference (p = 0.001).
CONCLUSIONS Eating behaviors are likely to affect cardio-metabolic risk factors, and the effects vary within gender groups.
Sensing and switching capabilities of a graphene-based perfect dual-band metamaterial absorber with analytical methods
Authors: Nejat Mohamad , Nozhat Najmeh 
Published: March 2020

In this paper, the simultaneous sensing and switching performance of a graphene-based plasmonic dual-band absorber in the terahertz region has been demonstrated and investigated. Due to the high confinement of graphene surface plasmons and the hydrophobic nature of graphene, the structure can be used as a refractive index sensor in biomedical applications such as detection of impurities of water, cancer cells, and STMV virus. The simulation results show an ultrahigh sensitivity of 360 THz/RIU and figure of merit of

654.54

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. Moreover, variation of the graphene chemical potential leads to a switching function between the perfect absorption and total reflection states, with the high extinction ratio of 12.15 dB and ultrafast response time of 1.5 ps. Two analytical methods of equivalent circuit model and transmission matrix have been used to validate the suggested idea of the proposed graphene-based structure. We have shown that there is a good agreement between the theoretical and simulation results. The specifications of our suggested structure are tunability, ultrahigh sensitivity, high extinction ratio, ultrafast response time, and simple design, which pave the ways for design and implementation of other multi-application terahertz plasmonic structures based on graphene in the future.
Extra-cavity-enhanced difference-frequency generation at 1.63  µm
Authors: Yang Chen , Liu Shi-Long , Zhou Zhi-Yuan , Li Yan , Li Yin-Hai , Liu Shi-Kai , Xu Zhao-Huai , Guo Guang-Can , Shi Bao-Sen 
Published: March 2020

A 1632 nm laser has highly important applications in interfacing the wavelength of rubidium-based quantum memories (795 nm) and the telecom band (typically 1550 nm) by frequency conversion in a three-wave mixing processes. A 1632 nm laser source based on pump-enhanced difference-frequency generation is demonstrated. It has 300 mW of output power, in agreement with simulations, and a 55% quantum efficiency. An average power fluctuation of 0.51% over 1 h was observed, and 200 kHz linewidth was measured using a delayed self-heterodyne method.
Graphene electrodes for electric poling of electro-optic polymer films
Authors: Wang Wen , Wu Jieyun , Chen Kaixin , Huang Quandong , Luo Jingdong , Seng Chiang Kin 
Published: March 2020

We propose electric poling of electro-optic (EO) polymer films with graphene electrodes. The use of graphene electrodes can waive the use of buffer layers and minimize the poling voltage. To demonstrate the idea, we prepared EO polymer thin-film waveguides for poling with traditional Au/ITO electrodes and graphene electrodes, where the EO polymer is a guest–host system formed by doping 15 wt% of dipolar polyene chromophore AJLZ53 into the random copolymer P(S-co-MMA). Our experiments confirm that the use of graphene electrodes can significantly reduce the poling voltage. For a 3.8-µm-thick EO polymer film, we achieve high EO coefficients of 82 pm/V at 1541 nm and 110 pm/V at 1300 nm with a poling voltage of 420 V. In addition, the use of graphene electrodes allows more flexible waveguide designs and can potentially simplify the fabrication of devices based on EO polymer.
Mongersen and SMAD-7 Inhibition, Not a Lucky 7 for Patients With IBD: When Trial Design Is as Important as Disease Therapy
Authors: Bewtra Meenakshi , Lichtenstein Gary R. 
Published: March 2020

Abstract
The phase II mongersen (GED-0301) trial produced unparalleled success rates in Crohn's disease and generated much hope for a crippling disease. Unfortunately, the subsequent phase III trial was terminated early because of a lack of efficacy. We discuss the differences in trial design that may have contributed to these disparate findings and how these findings may serve as a lesson in subsequent therapeutic trials in Crohn's disease.
Proton Pump Inhibitor Use and Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers in a Community-Based Population
Authors: Lee Jeffrey K. , Merchant Sophie A. , Schneider Jennifer L. , Jensen Christopher D. , Fireman Bruce H. , Quesenberry Charles P. , Corley Douglas A. 
Published: March 2020

INTRODUCTION:
Proton pump inhibitors (PPIs) are commonly used for gastrointestinal disorders; given they increase the systemic levels of gastrin, a trophic hormone, there is a concern about their carcinogenicity. This study evaluated the association between PPI use and gastrointestinal cancers.

METHODS:
We performed a nested case-control study in a large, community-based integrated healthcare setting. Cases were adults with gastric (n = 1,233), colorectal (n = 18,595), liver (n = 2,329), or pancreatic cancers (n = 567). Each case was matched with up to 10 controls by age, sex, race/ethnicity, medical facility, and enrollment duration. The primary exposure was defined as ≥2-year cumulative PPI supply. Data were obtained from pharmacy, cancer registry, and electronic medical record databases. Associations were evaluated using conditional logistic regression and adjusted for multiple confounders. We also evaluated the cancer risks separately by PPI dose, duration of use, and dose and duration.

RESULTS:
PPI use of ≥2-years was not associated with the risks of gastric (odds ratio [OR]: 1.07, 95% confidence interval [CI]: 0.81–1.42), colorectal (OR: 1.05, 95% CI: 0.99–1.12), liver (OR: 1.14, 95% CI: 0.91–1.43), or pancreatic cancers (OR: 1.22, 95% CI: 0.89–1.67), compared to non-users. In exploratory analyses, elevated cancer risks were primarily restricted to those with ≥10 years of PPI use, but no consistent associations were found for increasing PPI dose and/or duration of use.

DISCUSSION:
PPI use of ≥2 years was not associated with increased risks of gastrointestinal cancers. The cancer risks associated with PPI use of ≥10 years requires further study.
The “Cast Iron Site”—A Tale of Four Stoves from the 1845 Franklin Northwest Passage Expedition
Authors: Stenton Douglas R. , Park Robert W. 
Published: March 2020

Few detailed analyses exist for the majority of the sites that comprise the archaeological record of the 1845 Franklin Northwest Passage expedition. This paper presents the results of new investigations of an Inuit site (NgLj-9) at Erebus Bay on King William Island, Nunavut, containing materials derived from the 1845 Franklin expedition. The complex history of the origin and use of artifacts found at the site and its relationship to other Franklin sites and events associated with the expedition are revealed through the analysis and integration of archaeological, historical, and oral historical data.
Inuit Seal Hunting in Canada: Emerging Narratives in an Old Controversy
Authors: Farquhar Samantha D. 
Published: March 2020

Seal hunting in Canada is a historically controversial topic. Animal rights groups have campaigned that Atlantic Canadians inhumanely slaughter thousands of “baby” seals every year. The work of these animal rights groups has led to changes in national fisheries regulations and markets. The market changes have greatly affected the livelihoods of many Atlantic Canadians, but even more so of the Inuit who also hunt seals in Canada’s Arctic regions. Animal rights groups largely excluded and ignored the Inuit who depended on the larger Atlantic Canadian seal market. However, Inuit have recently mobilized though social media to reclaim the narrative surrounding seal hunting. Their campaign has helped change national policy. The Government of Canada has since created a scheme to increase market access to Inuit-harvested seals. Yet, little information is available for this scheme and its effectiveness needs to be further investigated.
Bioconditioning of Arctic Waters and Stimulation of Arctic Phytoplankton by Sea Ice Algae: Vulnerability to Increased Light
Authors: Apollonio Spencer 
Published: March 2020

Arctic sea ice algae produce extracellular organic products, which, as bioconditioners of seawater, may stimulate early summer growth of pelagic, under-sea-ice phytoplankton in low light and low temperature conditions. Sea ice algae are inhibited or decline in numbers if prematurely exposed to high light conditions, thereby reducing their ability to produce bioconditioners. As climate change creates an early reduction or removal of snow and sea ice cover, the result may be a decrease in primary phytoplankton production.
APPLIED Research on Banking Production Planning and Control in the Housing Investment Process
Authors: Novaes Luiz Fernando de Lyra , Paiva Sergio Antão , Barbosa Fabio Matera , Cardoso Helaine Coutinho , Almeida Ives Yokoyama de , Novaes Thomas Campos Silva de Lyra 
Published: March 2020

Goal: This article presents a PMM - Performance Measurement and Management system which analyzes 72 regional managerial offices (RMO) found on the database of a banking institution. Each of the offices has a portfolio of investments in real estates in Brazil financed by the Banking Institution. The PMM gives diagnosis of the performance of each of these offices through a data mining procedure from the years 2015 to 2017 and suggest on how the worst performing offices can replicate the best performing ones.
Design / Methodology / Approach: The PMM was designed to estimate an efficient model by Data Envelopment Analysis (DEA). Ranks the efficiency of the RMOs and provides managerial solutions with the background information upon which to base decisions.
Practical implications: The design of PMM has the ability to enable the institution of processing a more flexible and dynamic performance management. The practical implications achieved are reported in systematic analysis approach that testify the quality and effectiveness of this PMM modeling in conclusion section at table 8.
Results: The proposed PMM is a new approach paradigm to institution, in the way to set the best results on account of resources available. The current method used per the Institution sets effectiveness targets without accounting the resources spent.
Limitations of the investigation: The restrictions in time and resources did not make possible compare the current organizational method with the proposed PMM. A main question was not answered if the effectiveness RMOs are efficient too, or, vice-versa.
Originality / method value: This article is innovative as it introduces the ability to perform simulations in the DEA environment, principally because its possibility to rearrange the modeling from the evolution of institution performance. Also, the corporate aspect of adopting a universalized methodology for evaluating efficiency.
Субъективное благополучие: концептуализация, измерение и российская специфика
Authors: Алмакаева Анна Михайловна , Гашенина Наталья Валерьевна 
Published: March 2020

В статье представлен краткий обзор особенностей российской традиции исследования субъективного благополучия. Анализируется смысловая наполненность таких концептов, как «субъективное качество жизни», «социальное настроение», «социальное самочувствие». Авторы показывают, что наиболее распространенным в отечественной социальной литературе является понятие «социальное самочувствие», имеющее две трактовки: широкую и узкую. При этом лишь узкую трактовку следует считать аналогом субъективного благополучия (subjective well-being). В работе также описываются существующие российские и международные базы данных, которые могут служить источниками изучения благополучия во временной и межстрановой перспективе.
Благодарность. Мы выражаем искреннюю благодарность авторам, рецензентам, а также команде журнала «Мониторинг общественного мнения: экономические и социальные перемены» Анне Кулешовой, Анне Кокаревой и Илье Ломакину за плодотворную работу по подготовке этого номера. Мы также очень признательны Российскому научному фонду (РНФ) за финансирование исследовательского проекта № 18-18-00341 «Ценностная трансформация и субъективное качество жизни: региональная перспектива», благодаря которому возникла идея подготовить тематический выпуск, посвященный различным аспектам и специфике субъективного благополучия в России.
An extensive study of the regularity of solutions to doubly singular equations
Authors: Vespri Vincenzo , Vestberg Matias 
Published: March 2020

Abstract
In recent years, many papers have been devoted to the regularity of doubly nonlinear singular evolution equations. Many of the proofs are unnecessarily complicated, rely on superfluous assumptions or follow an inappropriate approximation procedure. This makes the theory unclear and quite chaotic to a nonspecialist. The aim of this paper is to fix all the misprints, to follow correct procedures, to exhibit, possibly, the shortest and most elegant proofs and to give a complete and self-contained overview of the theory.
Lifespan change in grammaticalisation as frequency-sensitive automation: William Faulkner and thelet aloneconstruction
Authors: Neels Jakob 
Published: March 2020

AbstractThis paper explores the added value of studying intra- and inter-speaker variation in grammaticalisation based on idiolect corpora. It analyses the usage patterns of the Englishlet aloneconstruction in a self-compiled William Faulkner corpus against the backdrop of aggregated community data. Vast individual differences (early Faulkner vs. late Faulkner vs. peers) in frequencies of use are observed, and these frequency differences correlate with different degrees of grammaticalisation as measured in terms of host-class and syntactic context expansion. The corpus findings inform general issues in current cognitive-functional research, such as the from-corpus-to-cognition issue and the cause/consequence issue of frequency. They lend support to the usage-based view of grammaticalisation as a lifelong, frequency-sensitive process of cognitive automation. To substantiate this view, this paper proposes a self-feeding cycle of constructional generalisation that is driven by the interplay of frequency, entrenchment, partial sanction and habituation.
Simultaneous Scheduling and Heat Integration of Batch Plants Using Unit-Specific Event Based Modelling
Authors: Mummana Semal Sekhar , Seepana Murali Mohan , Vooradi Ramsagar 
Published: March 2020

AbstractOver the past few decades of sustainable development, energy savings in batch processing facilities has played a vital role. The increasing trend in production of high value and low volume products in food, pharmaceutical industries and fine/specialty chemicals is driving the development of material, energy and water integrated scheduling techniques for multiproduct/multipurpose batch plants. In the present study, a three index Unit Specific Event Based (USEB) model is proposed for the simultaneous short-term scheduling and heat integration of batch plants. A mixed integer linear programming (MILP) model is proposed to handle direct heat integration. The performance of the proposed model is evaluated by considering two benchmark examples.