bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-Human, Double-Blind, Randomized Controlled Trial of an Oral Dose of GnRH Antagonist TU2670 in Healthy Women
Authors: Han Sungpil , Cho Yong-Soon , Yoon Seok-Kyu , Lim Kyoung Soo , Cho Sang-Heon , Kim JaeWoo , Choe Sangmin , Jung Jinah , Ghim Jong-Lyul , Choi SangKeun , Lee Minhee , Kim Seon Mi , Kim Hun-Taek , Lim Hyeong-Seok , Yoon Shim Jae , Bae Kyun-Seop 
Published: December 2020

Abstract

Objective
To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TU2670, a novel orally active, nonpeptide gonadotropin-releasing hormone (GnRH) antagonist administered to healthy female participants.

Methods
This was a first-in-human, multicenter, phase 1, randomized, double-blind, placebo-controlled, single-dose ascending trial that took place in multiple medical centers. A total of 16 healthy premenopausal women (23 to 45 years of age) were randomized and received 20, 40, 80, and 160 mg TU2670 (GnRH antagonist) or placebo 7 days (±1 day) after the onset of menstrual bleeding. We performed a noncompartmental analysis for pharmacokinetic parameters and calculated relative minimum concentration values (Cmin, % Baseline) of serum pharmacodynamic (PD) markers (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and estradiol).

Results
There were no significant differences among treatments with respect to vital signs, electrocardiography, adverse events, ovulation test results, and ultrasonography. The median Tmax of TU2670 occurred 0.75 to 1.00 hours after dosing, and concentrations then declined, with a mean apparent half-life (t1/2) of 3.0 to 5.9 hours. AUClast (17.7-417.9 ng·h/mL) and Cmax (8.1-95.4 ng/mL) increased in a dose-dependent manner. The PD analysis after a single administration of TU2670 revealed dose-dependent suppression of LH, FSH, and estradiol. Maximal suppression of the pre-dose baseline (%) was 58% to 82% at 6 to 8 hours for LH, 28% to 39% at 6 to 12 hours for FSH, and 34% to 82% at 12 to 24 hours for estradiol.

Conclusion
The single administration of TU2670 in healthy premenopausal women was well tolerated and resulted in the dose-dependent suppression of LH, FSH, and estradiol, suggesting rapid and significant inhibition of pituitary and ovarian hormones.
The effectiveness of the resiliency training on the perceived stress and coping strategies of the mothers of the children with autism
Authors: Kord Nooshin , Bazzazian Saeideh 
Published: December 2020

Aim of the studyThis study is conducted in order to evaluate the effectiveness of the resiliency training on the perceived stress and coping strategies of the mothers of the children with autism.Subject or material and methodsThis study is quasi-experimental with the pretest-posttest design and the control group. The population of this study is consisted of all of the mothers of the autistic children who are aged between 3 to 10 years old and received services at the Tehran Autism Center in 2018. The study sample is consisted of 30 mothers who were selected by the convenient sampling method, and were randomly assigned into the study (15 people) and control (15 people) groups. The Coping with Stressful Conditions Scale of Endler and Parker (1990) and the Perceived Stress Scale of Cohen et al. (1983) were used in order to collect the data. The Resiliency training was given to the study group in nine sessions, and each session lasted for one hour. The SPSS-22 statistical software was used for the data analysis.ResultsThe results of this study showed that the intervention (the resiliency training) improved the problem-focused coping strategies in the study group (P <0.05). It also reduced the perceived stress, and the emotion-focused, and avoidance coping strategies (P <0.05).DiscussionHowever, there was no significant difference between the pre-test and post-test in the control group.ConclusionsTotally, it can be concluded that the resiliency training plays an effective role in the management of the stress in the mothers of the autistic children.
The archetype of the double in middle adolescence: Theoretical reflections based on action research
Authors: Schiltz Lony 
Published: December 2020

Abstract

Background
Stories written under musical induction allow studying symbolic figures emerging during the psychotherapeutic process. During multimodal arts psychotherapy, based on a combination of active music therapy and the production of stories under musical induction, the archetype of the alter ego frequently appears in texts written by adolescents (Schiltz, 2008). This archetype shows its different facets during the psychotherapeutic process.

Methods and research questions
With the help of a qualitative study, based on the phenomenological content analysis of the TAT and the stories written under musical induction with N=52 students suffering from emotional (subgroup I) or conduct disorders (subgroup D), we answered the following questions:

•	Can we recognise in these symbols compensatory features regarding the person’s initial problems?
•	Do they gradually expand during the therapeutic progress, so that they reflect the integration of the hidden and split parts of the self?
•	What is generally their role in the adolescents’ search for identity, beyond the realm of the pathology?

Results
The results of the study opened psychotherapeutic perspectives for tertiary prevention in adolescence.
Nanometallic antenna-assisted amorphous silicon waveguide integrated bolometer for mid-infrared
Authors: Wu Yangbo , Qu Zhibo , Osman Ahmed , Wei Chen , Cao Wei , Tarazona Antulio , Oo Swe Zin , Chong Harold M. H. , Muskens Otto L. , Mashanovich Goran Z. , Nedeljkovic Milos 
Published: December 2020

Bolometers are thermal detectors widely applied in the mid-infrared (MIR) wavelength range. In an integrated sensing system on chip, a broadband scalable bolometer absorbing the light over the whole MIR wavelength range could play an important role. In this work, we have developed a waveguide-based bolometer operating in the wavelength range of 3.72–3.88 µm on the amorphous silicon (a-Si) platform. Significant improvements in the bolometer design result in a

20
×

improved responsivity compared to earlier work on silicon-on-insulator (SOI). The bolometer offers 24.62% change in resistance per milliwatt of input power at 3.8 µm wavelength. The thermal conductance of the bolometer is

3.86
×

1

0

−
5

W

/

K

, and an improvement as large as 3 orders magnitude may be possible in the future through redesign of the device geometry.
Polarization-independent fiber-chip grating couplers optimized by the adaptive genetic algorithm
Authors: Wang Xiaofei , Yu Hui , Huang Qikai , Zhang Zhaoyang , Zhou Zhiyan , Fu Zhilei , Xia Penghui , Wang Yuehai , Jiang Xiaoqing , Yang Jianyi 
Published: December 2020

One-dimensional polarization-independent grating couplers are demonstrated with the aid of the adaptive genetic algorithm optimization. By adjusting the relative weight between the coupling efficiency and the bandwidth of the polarization-dependent loss (PDL), we control the evolution direction and customize the final performance of the device. Two specific designs are generated by giving more weight to the coupling efficiency and the PDL bandwidth, respectively. Coupling efficiencies of the first design are measured to be

−

7.6

d
B

and

−

7.9

d
B

at 1550 nm for TE and TM polarizations, respectively, while its 1.0 dB PDL bandwidth is 25.0 nm. In contrast, the second design presents higher coupling efficiencies of

−

7.6

d
B

and

−

7.2

d
B

at 1550 nm for TE and TM polarizations, respectively. However, its 1.0 dB PDL bandwidth is 22.0 nm.
Femtosecond pulse generation from external cavity diode laser based on self-mode-locking
Authors: Alloush M. Ali , Brenner Carsten , Calò Cosimo , Hofmann Martin R. 
Published: December 2020

In this Letter, we report optical pulse generation from a single-section diode gain chip, employed in an external cavity geometry based on the self-mode-locking regime. The gain chip emits light at 1550 nm wavelength range. The external cavity is operated at various repetition rates, ranging from 1 to 2.5 GHz. An optical pulse width of approximately 650 fs is obtained by fitting a Lorentzian distribution. A low RF spectral width of 78.875 kHz is measured corresponding to a low pulse-to-pulse RMS timing jitter of 1.273 ps. This system paves the way towards ultra-compact, cost-effective, and chirp-compensated femtosecond laser pulse sources with adjustable repetition rates.
Long-term trends in the incidence of peritoneal dialysis-related peritonitis disclose an increasing relevance of streptococcal infections: A longitudinal study
Authors: Santos Joana Eugénio , Rodríguez Magariños Catuxa , García Gago Leticia , Astudillo Jarrín Daniela , Pértega Sonia , Rodríguez-Carmona Ana , García Falcón Teresa , Pérez Fontán Miguel 
Published: December 2020

BackgroundThe selective impact of strategies for prevention of PD-related peritonitis (PDrP) may have modified, in the long term, the causal spectrum, clinical presentation and outcomes of these infections.ObjectivesTo compare trends in the incidence of PDrP by different microorganisms during a 30-year period, with a particular focus on streptococcal infections. To analyze the clinical presentation and outcomes of these infections. Secondarily, to investigate how the isolation of different species of streptococci can influence the clinical course of PDrP by this genus of bacteria.MethodFollowing a retrospective, observational design we investigated 1061 PDrP (1990–2019). We used joinpoint regression analysis to explore trends in the incidence of PDrP by different microorganisms, and compared the risk profile (Cox), clinical presentation and outcomes (logistic regression) of these infections.Main resultsOur data showed a progressive decline in the incidence of PDrP by staphylococci and Gram negative bacteria, while the absolute rates of streptococcal (average annual percent change +1.6%, 95% CI -0.1/+3.2) and polymicrobial (+1.8%, +0.1/+3.5) infections tended to increase, during the same period. Remarkably, streptococci were isolated in 58.6% of polymicrobial infections, and patients who suffered a streptococcal PDrP had a 35.8% chance of presenting at least one other infection by the same genus. The risk profile for streptococcal infections was comparable to that observed for PDrP overall. Streptococcal PDrP were associated with a severe initial inflammatory response, but their clinical course was generally nonaggressive thereafter. We did not observe a differential effect of different groups of streptococci on the clinical presentation or outcome of PDrP.ConclusionsTime trends in the incidence of PDrP by different microorganisms have granted streptococci an increasing relevance as causative agents of these infections, during the last three decades. This behaviour suggests that current measures of prevention of PDrP may not be sufficiently effective, in the case of this genus of microorganisms.
Transnational collaboration in building educational research capacity in a new university: An applied phenomenographic investigation
Authors: Smyth Keith , Rennie Frank , Davies Gareth , Tobgay Sonam 
Published: December 2020

This paper reports on a phenomenographic investigation concerning the perceptions of primarily early career academics on the value and importance of educational research, and the challenges and enablers of establishing and building educational research capacity, within a new university in a developing country. The study was conducted as part of a three year project which itself is based within a longitudinal programme of collaboration between the Royal University of Bhutan (RUB) and the University of the Highlands and Islands (UHI). The paper outlines the transnational collaborations between the two universities to date, before considering key issues in the development of educational research and an educational research culture within universities that are not research intensive, and for whom educational research is a nascent or emerging area.
The rationale and methodological approach for the phenomenographic investigation, which seems to be the first phenomenography to address perceptions relating to the development of educational research within the context of a new university, are then considered. The main findings resulting from the phenomenographic process of thematic analysis are subsequently presented. This includes a synthesis and articulation of the findings in the form of a phenomenographic ‘outcome space’ that pertains to the academics’ motivations and perceptions in relation to the development of educational research at RUB. The paper then articulates how the findings of the phenomenography were applied in identifying and implementing tangible interventions to support the participants to engage in conducting and disseminating educational research projects relating to dimensions of their own educational practice. The paper concludes with recommendations and lessons learned relating to the development of educational research capacity in emergent and transnational collaborative contexts.
TEACHER’S FEEDBACK IN TEACHING SPEAKING
Authors: Aini Luluk Rahmatia Trisna , Rochmahwati Pryla 
Published: December 2020

This research deals with teacher’s feedback in teaching speaking at the seventh grade of SMPN 4 Ponorogo. This research was conducted for several purposes. They are: 1) to know the implementation of teacher’s feedback in teaching speaking at the seventh grade of SMPN 4 Ponorogo, 2) to know students’ response to the teacher’s feedback in teaching speaking at the seventh grade of SMPN 4 Ponorogo. The researcher applied qualitative research approach and the case study was the research design. In this research, the researcher analyzed the data by Mattew B Miles and Michael Hubberman’s; data reduction, data display, and conclusion and verifications data. It is a methodological on data analysis which involved an interview, an observation, and a documentation. Then both English teacher and the students especially 7G and 7H classes of SMPN 4 Ponorogo were the source and the object of this study. The findings of this study clarified that: (1) the English teacher implemented this feedback by giving tasks and inviting performance. Starting by the teacher chose the task and read the task to give the example of how to pronounce the words. Then the students should immitate it and improve their speaking of what they have took from the text in front of the class. While enjoying the students’ performance, the teacher took the scores and gave the feedback. It concluded on oral and written feedback. Something difference on this point than other points of feedback, the teacher applied on excellent point which is same as 10 scores in 1 point. Focusing on lower students to motivate their English skills and upgrading the students (the middle and the upper one) were the teacher’s goal in this strategy implementation. (2) the students’ response was very positive. It is shown when the researcher looked at the students were very active during doing the assignments. Through this feedback, the students can get several points in learning English such as feeling motivated and appreciated, getting an active assessment, and getting additional scores to upgrade their low scores. In the end, the researcher concluded that the teacher’s feedback applied positively in increasing students’ speaking ability.
Tertiary-Recovery Improvement of Steam Injection Using Chemical Additives: Pore-Scale Understanding of Challenges and Solutions Through Visual Experiments
Authors: Pratama Randy Agra , Babadagli Tayfun 
Published: December 2020

Summary
Our previous research, honoring interfacial properties, revealed that the wettability state is predominantly caused by phase change—transforming liquid phase to steam phase—with the potential to affect the recovery performance of heavy oil. Mainly, the system was able to maintain its water-wetness in the liquid (hot-water) phase but attained a completely and irrevocably oil-wet state after the steam-injection process. Although a more favorable water-wetness was presented at the hot-water condition, the heavy-oil-recovery process was challenging because of the mobility contrast between heavy oil and water. Correspondingly, we substantiated that the use of thermally stable chemicals, including alkalis, ionic liquids, solvents, and nanofluids, could propitiously restore the wettability. Two types of heavy oil (450 and 111,600 cp at 25°C) were used in a glass-bead-pack model at steam temperatures up to 200°C. Initially, the glass-bead-pack model was saturated with synthesized formation water and then displaced by heavy oils. The process was then followed by steam injection generated by escalating the temperature to steam temperature and maintaining a pressure lower than saturation pressure. Subsequently, the previously selected chemical additives were injected into the glass-bead-pack model as a tertiary-recovery application to further evaluate their performance. We observed that phase change (in addition to the capillary forces) was substantial in affecting both the phase distribution/residual oil in the porous media and wettability state. A more oil-wet state was evidenced in the steam case rather than in the liquid (hot-water) case. Despite the conditions, auspicious wettability alteration was achievable with thermally stable surfactants, nanofluids, water-soluble solvent [dimethyl ether (DME)], and switchable-hydrophilicity tertiary amines (SHTAs), improving the capillary number. The residual oil in the porous media yielded after injections could be favorably diminished post-chemical injection (for example, in the case of DME). In addition, more than 80% of the remaining oil was recovered after adding this chemical to steam. Analyses of wettability alteration and phase distribution/residual oil in the porous media through glass-bead-pack-model visualization on thermal applications present valuable perspectives in the phase-entrapment mechanism and the performance of heavy-oil recovery. This research also provides evidence and validations for tertiary recovery beneficial to mature fields under steam applications.
Monitoring and Characterization of the Spatial Distribution of Rhynchophorus Palmarum in Conventional Oil Palm Planting
Authors: Santos Artur , Farias Paulo , Pinho Raphael , Tinôco Ricardo , Silva Brenda , Batista Telma , Silva Gisele , Silva Anderson 
Published: December 2020

Abstract
The aim of this work was to evaluate the spatial and temporal distribution of males and females of R. palmarum using geostatistics as a tool. The experiment was carried out in a commercial oil palm plantation area, in the municipality of Moju (PA), Brazil. Monthly samplings were performed, from June 2013 to May 2014. The sampling of insects was carried out through bucket-type traps with pheromone and food attractant, all georeferenced. Population fluctuation, Pearson correlation and spatial analysis were performed through geostatistics. Among the abiotic factors evaluated, only relative humidity and insolation showed a significant correlation for the insect population. The spherical model was the one that presented the best fit, with ranges for males of 240 to 550 meters and females of 300 to 550 meters. The Kriging maps indicated for both sexes, a moderately pattern of aggregate infestation, located on the edges of the oil palm plantation block, mainly close to the native forest. The results indicate that the traps should be distributed on the edges of the oil palm plantations.
miR-489 confines uncontrolled estrogen signaling through a negative feedback mechanism and regulates tamoxifen resistance in breast cancer
Authors: Soni Mithil , Saatci Ozge , Patel Yogin , Raja Manikanda Raja Keerthi , Liu Xinfeng , Xu Peisheng , Wang Hongjun , Fan Daping , Sahin Ozgur , Chen Hexin 
Published: December 2020

Abstract
Background Approximately 75% of diagnosed breast cancer tumors are Estrogen receptor (ER) positive tumors and are associated with better prognosis due to their response to hormonal therapies. However, around 40% of patients relapse after hormonal therapies. In the current study, we aimed to evaluate miR-489 as a novel molecular target to combat tamoxifen resistance.Methods Genomic analysis of gene expression profiles in primary breast cancers and tamoxifen resistant cell lines unveiled the potential role of miR-489 in regulation of estrogen signaling and development of tamoxifen resistance. We manipulated miR-489 expression in breast cancer cell lines by transient transfection of miR-489 mimic or establishment of knockout cell lines using the CRISPR/Cas9 system to study the reciprocal regulation of miR-489 and estrogen/ER signaling pathways. Cell proliferation, tumor sphere formation assay and flow cytometry analysis were conducted to investigate the role of miR-489 on estrogen-induced cell proliferation, cancer stem cells expansion and development of tamoxifen resistance.Results miR-489 expression was significantly downregulated in tamoxifen-resistant cell lines. Low levels of miR-489 were associated with poor clinical outcomes in patients with hormone treatment. In vitro analysis showed that loss of miR-489 expression promoted tamoxifen resistance while overexpression of miR-489 in tamoxifen-resistant cells restored tamoxifen sensitivity. Mechanistically, we found that miR-489 is an estrogen regulated miRNA that negatively regulated estrogen receptor signaling by using at least the following two mechanisms: i) modulation of ER phosphorylation status by inhibiting MAPK and AKT kinase activities; ii) regulation of nucleus to cytosol translocation of estrogen receptor α (ERα) by decreasing p38 expression and consequently ER phosphorylation. In addition, miR-489 could break the positive feed-forward loop between estrogen-ERα axis and p38 MAPK in breast cancer cells which was necessary for its function as transcription factor.Conclusion Our study unveiled the underlying molecular mechanism by which miR-489 regulates estrogen signaling pathway through a negative feedback loop and uncovered its role in the development of and overcoming tamoxifen resistance in breast cancers.