bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Trail, the Archive, the Museum, and the Book: Confronting Materiality in Literary Studies
Authors: Haubenreich Jacob 
Published: November 2020

Abstract
This article examines the persistence of the notion of the immaterial text in literary studies, now decades into the so-called material turn. Digitization of manuscripts increasingly confronts us with the facts of textual materiality and material authorship, yet many scholars remain ill-equipped to engage these traces in order to expand the possibilities of textual interpretation. The journeys of Peter Handke’s notebooks serve as a case study on how to interrogate various definitions of text and methodological approaches that reinforce an understanding of texts as immaterial. This article thus elucidates the conceptual and methodological impediments to more comprehensively integrating materiality into interpretation; an uneasiness, for example, about approaching authorship—the process and agency of textual production—lingers despite resurrections since the Author’s “death” and more recent transdisciplinary retheorizations of agency. The article finally looks to reflections on materiality in another field, art history, to clarify the reasons that integrating materiality into interpretative criticism remains so difficult, so that the field might begin to move beyond these obstacles.
The Making of Viequenses
Authors: Cruz Soto Marie 
Published: November 2020

Abstract
This article delves into the history of medical institutions, birthing practices, and reproductive rights in Vieques. The exploration exposes contradictions at the heart of Puerto Rico’s colonial modernity. Around the middle of the twentieth century, Puerto Ricans were encouraged to depend on the colonial state and medical establishment for guarantee of life, health, and general well-being. This encouragement clashed with the militarized colonialism imposed on Viequenses. The 1940s expropriations—through which the U.S. Navy gained control over three-fourths of Vieques—devastated the community. And the interventions by the colonial state and medical establishment proved at times meek, complicit, and ineffective. In 2003, unruly colonial citizens evicted the Navy. Their actions were part of a struggle for the survival and well-being of the Viequense island community. In this article, the author argues that la lucha viequense has been fundamentally shaped by the concerns and actions of women who placed reproductive rights at the center of the struggle.
Uncharted routes: exploring the relevance of auxin movement via plasmodesmata
Authors: Paterlini Andrea 
Published: November 2020

ABSTRACT
Auxin is an endogenous small molecule with an incredibly large impact on growth and development in plants. Movement of auxin between cells, due to its negative charge at most physiological pHs, strongly relies on families of active transporters. These proteins import auxin from the extracellular space or export it into the same. Mutations in these components have profound impacts on biological processes. Another transport route available to auxin, once the substance is inside the cell, are plasmodesmata connections. These small channels connect the cytoplasms of neighbouring plant cells and enable flow between them. Interestingly, the biological significance of this latter mode of transport is only recently starting to emerge with examples from roots, hypocotyls and leaves. The existence of two transport systems provides opportunities for reciprocal cross-regulation. Indeed, auxin levels influence proteins controlling plasmodesmata permeability, while cell–cell communication affects auxin biosynthesis and transport. In an evolutionary context, transporter driven cell–cell auxin movement and plasmodesmata seem to have evolved around the same time in the green lineage. This highlights a co-existence from early on and a likely functional specificity of the systems. Exploring more situations where auxin movement via plasmodesmata has relevance for plant growth and development, and clarifying the regulation of such transport, will be key aspects in coming years.
This article has an associated Future Leader to Watch interview with the author of the paper.
Concomitant weekly cisplatin-based chemoradiotherapy in head and neck cancer: the value of a second measured glomerular filtration rate during treatment
Authors: Akmar Lily , Cunnell Michelle , Kelly Charles , Kovarik Josef , Iqbal Muhammad Shahid 
Published: November 2020

Objectives:
To assess the efficacy of the second measured glomerular filtration rate (GFR) during the course of weekly cisplatin-based chemoradiotherapy in head and neck cancer.

Methods:
Data was collected on consecutive 221 head and neck cancer patients who underwent cisplatin-based chemoradiotherapy.

Results:
68% patients managed to complete at least five out six proposed cycles of cisplatin, with a cumulative dose of ≥200 mg/m2. 181 patients underwent second measured GFR and it showed a mean fall in measured GFR by 12.0 ml/min/1.73 m2 (p &lt; 0.0001). Out of these 181 patients, in 16 patients (9%), the decision to discontinue cisplatin was purely based on a low second measured GFR (below 50 ml/min/1.73 m2).

Conclusion:
Our study has shown that obtaining a second measured GFR is valuable in 9% of these patients. We propose that this should be considered as a standard procedure in these settings and also should be considered incorporating this additional safety measure, into future clinical trials as a mandatory procedure.

Advances in knowledge:
To the best of author’s knowledge, this is first study of its kind. The results of our study suggest that it should be a standard procedure of obtaining a second GFR in these settings.
The complete genome sequences of 22 parrot species (Psittaciformes, Aves)
Authors: Hains Taylor , O'Neill Kathleen , Velez Jafet , Speed Nancy , Clubb Susan , Oleksyk Taras , Pirro Stacy 
Published: November 2020

The parrots (Psittaciformes, Aves) are a group of colorful, intelligent, long-lived birds with a wide range of body sizes and plumage colors and patterns. One third of the parrot species is threatened with extinction due to habitat loss and the pet trade, a larger percentage than any other comparable bird order. We present the complete genome sequences of 22 species of parrots from 14 genera and 3 families: Anodorhynchus hyacinthinus, Ara ararauna, Ara chloropterus, Ara glaucogularis, Ara militaris, Aratinga solstitialis, Aratinga weddellii, Cacatua leadbeateri, Eclectus roratus, Eupsittula pertinax, Guaruba guarouba, Lorius garrulus, Myiopsitta monachus, Nymphicus hollandicus, Pionus senilis, Psittacus erithacus, Psittacus timneh, Psitteuteles goldiei, Pyrrhura frontalis, Pyrrhura griseipectus, Pyrrhura molinae, Pyrrhura perlata. Genomic data can be used to better understand species identity, hybridization, genetic diversity, and identification of animal products possibly derived from endangered species.
Neuropsychological rehabilitation interventions for people with an acquired brain injury and their caregivers. A protocol for a systematic review of economic evaluation
Authors: Mitchell Eileen , Ahern Elayne , Saha Sanjib , Trepel Dominic 
Published: November 2020

Background: New emerging evidence has demonstrated the need for effective interventions to help people living with an acquired brain injury (ABI). Evidence on cost-effectiveness, which can help inform use of limited resources, is scarce in this area and therefore the purpose of this systematic review is to critically appraise and consolidate the current evidence on economic evaluations of ABI rehabilitation interventions. Methods: Systematic review methodology will be applied to identify, select and extract data from published economic evaluation studies (trial-based, non-trial based, simulation-based, decision model and trial-based model economic evaluations) of ABI treatment interventions in adults. A systematic literature search will be conducted on the following electronic databases: EMBASE, Econlit, CINAHL, Medline, Econlit, the National Health Service Economic Evaluation Database and PsyclNFO. This review will only include cost-effectiveness analysis studies (e.g., cost per life year gained), cost-benefit and cost minimisation analyses in which the designs were randomised controlled trials (RCTs), non-RCT studies, cost-utility analyses (e.g., cost per quality-adjusted life year (QALY) gained or cost per disability-adjusted life year averted), cohort studies, and modeling studies. Only studies that were published in English, associated with adults who have an ABI will be included. There will be no restrictions on perspective, sample size, country, follow-up duration or setting. The search strategy terms will include the following: acquired brain injury, brain*; cost*; or cost–benefit analysis*. Following data extraction, a narrative summary and tables will be used to summarize the characteristics and results of included studies. Discussion: The findings from this review will be beneficial to health policy decision makers when examining the evidence of economic evaluations in this field. In addition, it is anticipated that this review will identify gaps in the current economic literature to inform future-related research. Systematic review registration: PROSPERO CRD42020187469 (25th June 2020).
Developing an open educational resource for open research: Protocol for the PaPOR TRAIL project
Authors: Egan Sophia , Tobin Mary , Palmer Brendan , Coffey Aoife , Dahly Darren , Houghton Catherine , Ó Carragáin Eoghan , Toomey Elaine , Dockray Samantha , Matvienko-Sikar Karen 
Published: November 2020

Background: Open research involves actions at all stages of the research cycle to make the research process and outputs more transparent and accessible. Though a number of initiatives exist for researchers at PhD, post-doctoral and more senior levels, there remains a critical need for educational resources for research students at earlier career stages and across disciplines. The aim of the Principles and Practices of Open Research: Teaching, Research, Impact, and Learning (PaPOR TRaIL) project is to develop an open educational resource (OER) on the principles and practice of open research for undergraduate and master’s students. Methods: In stage 1, interviews and surveys of students and supervisors are being conducted to explore students’ and supervisors’ knowledge, attitudes, and experiences of open research, in addition to needs and preferences for the content and delivery of the OER. Stage 2 involves development of the OER content and delivery, based on Stage 1 engagement and national and international guidance on best practice in conducting and teaching open research. In Stage 3, students and supervisors will evaluate the developed OER and provide feedback in terms of OER usability, learning experience and learning outcomes. This feedback will guide revisions and finalisation of the OER content, format and learning activities. Discussion: The PaPOR TRaIL project will develop an evidence-based OER that provides a foundation in all aspects of open research theory & practice. Teaching undergraduate and master’s students open research will promote development of core research values and equip them with transferable competencies and skills, including how to conduct and use research in a trustworthy and ethical manner within and beyond academia. Enhancing teaching and learning of open research will promote better teaching and research outcomes that will benefit individuals, universities, and science more broadly.
Anti-tumour effect of tocilizumab for osteosarcoma cell lines
Authors: Hagi Tomohito , Nakamura Tomoki , Kita Kouji , Iino Takahiro , Asanuma Kunihiro , Sudo Akihiro 
Published: November 2020

Aims Tocilizumab, an interleukin-6 (IL-6) receptor (IL-6R) targeting antibody, enhances the anti-tumour effect of conventional chemotherapy in preclinical models of cancer. We investigated the anti-tumour effect of tocilizumab in osteosarcoma (OS) cell lines. Methods We used the 143B, HOS, and Saos-2 human OS cell lines. We first analyzed the IL-6 gene expression and IL-6Rα protein expression in OS cells using reverse transcription real time quantitative-polymerase chain reaction (RT-qPCR) analysis and western blotting, respectively. We also assessed the effect of tocilizumab on OS cells using proliferation and invasion assay. Results The OS cell lines 143B, HOS, and Saos-2 expressed IL-6R. Recombinant human IL-6 treatment increased proliferation of 143B and HOS cells. Tocilizumab treatment decreased proliferation and invasion of 143B, HOS, and Saos-2. Conclusion In conclusion, we confirmed the production of IL-6 and the expression of IL-6R in OS cells and demonstrated that tocilizumab inhibits proliferation and invasion in OS cells. Cite this article: Bone Joint Res 2020;9(11):821–826.
Short-term outcomes after Ivor Lewis oesophagectomy for cancer during the COVID-19 pandemic
Authors: Chan DSY , MacCormick A , Rashid B , Ariyarathenam A , Humphreys L , Sanders G , Wheatley T , Berrisford R 
Published: November 2020

Introduction Elective surgery in the UK came to a halt during the early part of the COVID-19 pandemic. As COVID-19-related infection and mortality rates in Devon and Cornwall were relatively low, however, urgent elective surgery continued in Plymouth, with the necessary precautions in place. This study aimed to assess outcomes following Ivor Lewis oesophagectomy (ILO) during the pandemic. Methods We prospectively analysed details of 20 consecutive patients who underwent ILO for cancer over a 3-month period between 17 March and 12 June 2020. All patients underwent COVID-19 swab testing 24–48 hours before surgery and during admission when clinically indicated. The primary outcome measure was COVID-19-related morbidity. Secondary outcome measures were non-COVID-19-related morbidity, mortality and length of hospital stay. Results Twenty patients underwent ILO during the study period. All patients identified as white British. No patients tested positive for COVID-19 pre- or postoperatively. There was no COVID-19-related morbidity. There was no in-hospital mortality. Seven patients developed pneumonia, which settled with antibiotics. One patient developed an anastomotic leak, which was treated conservatively. One patient returned to theatre for a para-conduit hernia repair. The median length of hospital stay was nine days. One patient required admission to the high dependency unit for inotropic support for two days. Conclusions ILO can be performed safely during the COVID-19 pandemic with the necessary precautions in place.
Maximal single-frequency electromagnetic response
Authors: Kuang Zeyu , Zhang Lang , Miller Owen D. 
Published: November 2020

Modern nanophotonic and meta-optical devices utilize a tremendous number of structural degrees of freedom to enhance light–matter interactions. A fundamental question is how large such enhancements can be. We develop an analytical framework to derive upper bounds to single-frequency electromagnetic response, across near- and far-field regimes, for any materials, naturally incorporating the tandem effects of material- and radiation-induced losses. Our framework relies on a power-conservation law for the polarization fields induced in any scatterer. It unifies previous theories on optical scattering bounds and reveals new insight for optimal nanophotonic design, with applications including far-field scattering, near-field local-density-of-states engineering, optimal wavefront shaping, and the design of perfect absorbers. Our bounds predict strikingly large minimal thicknesses for arbitrarily patterned perfect absorbers, ranging from 50–100 nm for typical materials at visible wavelengths to micrometer-scale thicknesses for polar dielectrics at infrared wavelengths. We use inverse design to discover metasurface structures approaching the minimum-thickness perfect-absorber bounds.
Long-term outcome of arthroscopic debridement of massive irreparable rotator cuff tears
Authors: Vogler Tim , Andreou Dimosthenis , Gosheger Georg , Kurpiers Nico , Velmans Clara , Ameziane Yacine , Schneider Kristian , Rickert Carolin , Liem Dennis , Schorn Dominik 
Published: November 2020

Objectives
To evaluate the clinical and radiographic outcome of low-demand patients with massive rotator cuff tears undergoing arthroscopic debridement in mid- and long-term follow-up, as well as the rate of conversion to reverse shoulder arthroplasty.

Methods
We performed a retrospective analysis of 19 patients with a mean age at surgery of 68 years (range, 55–80 years) from a previously described consecutive cohort and after a mean follow up of 47 month (FU1) and 145 month (FU2). The functional outcome was evaluated with the VAS score, the American Shoulder and Elbow Surgeons (ASES) score, and the age- and gender-adjusted Constant (aCS) score. The radiographic outcome was classified according to the Hamada classification. Non-parametric analyses were carried out with the Mann-Whitney U for independent samples and the Wilcoxon signed-rank test for related samples.

Results
Five patients (26%) developed symptomatic cuff tear arthropathy and underwent reverse shoulder arthroplasty after a mean time of 63 months (range, 45–97 months). These patients were excluded from further analyses. The mean VAS score of the remaining 14 patients at FU1 was significantly lower compared to preoperatively (P = .041), while there were no significant differences between the VAS score at FU1 and FU2 (P = 1.0). The ASES score of the affected shoulder at FU1 was significantly higher compared to prior to surgery (P = .028), while there were no significant differences between the scores of the affected shoulder between FU1 and FU2 (P = .878). While the ASES score of the contralateral shoulder at FU1 was significantly higher than the score of the affected shoulder (P = .038), there were no significant differences in the ASES scores of the affected and the healthy shoulder at FU2 (P = .575). The evaluation of the aCS produced similar results. A progression of the Hamada grade was documented in 6 patients.

Conclusions
Arthroscopic debridement is a safe and valid option for low-demand middle-age or elderly patients with symptomatic massive rotator cuff tears, leading to a significant pain relief and significantly improved functional outcome at mid- and long-term follow up. However, about a quarter of the patients in our cohort had to undergo reverse shoulder arthroplasty due to symptomatic cuff tear arthropathy. Furthermore, some of the remaining patients continued to undergo radiographic progression. This might be due to the natural history of their disease and/or the surgical procedure, and the clinical relevance of this finding should be evaluated in further studies.
Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution?
Authors: Boiza-Sánchez Macarena , Manso Rebeca , Balagué Olga , Chamizo Cristina , Askari Elham , Salgado Rocío Nieves , Blas-López Carlos , Aguirregoicoa-García Elena , Menárguez Javier , Santonja Carlos , Adrados Magdalena , Limeres-González Miguel Ángel , Piris Miguel Ángel , Rodríguez-Pinilla Socorro María 
Published: November 2020

Aim
Lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell-neoplasm with involvement of the bone marrow. At least 90% of LPLs carry MYD88-L265P mutation and some of them (~10%) transform into diffuse large B-cell-lymphoma (DLBCL).

Material and methods
Over the past 15 years we have collected 7 cases where the both LPL and DLBCL were diagnosed in the same patient. Clinical records, analytical data and histopathological specimens were reviewed. FISH studies on paraffin-embedded tissue for MYC, BCL2 and BCL6 genes were performed, as well as MYD88-L265P mutation and IGH rearrangement analysis by PCR. A mutational study was done by massive next generation sequencing (NGS).

Results
There were 4 women and 3 men between 36–91 years of age. Diagnoses were made simultaneously in 4 patients. In two cases the LPL appeared before the DLBCL and in the remaining case the high-grade component was discovered 5 years before the LPL. In 6 cases both samples shared the MYD88-L265P mutation. IGH rearrangement analysis showed overlapping features in two of 6 cases tested. Mutational study was evaluable in three cases for both samples showing shared and divergent mutations.

Conclusions
These data suggest different mechanisms of DLBCL development in LPL patients.
La obra cinematográfica de Shadi Abdel Salam: el cine como herramienta de recuperación del pasado faraónico
Authors: Montes Ibars Samuel 
Published: November 2020

Este artículo tiene como objetivo principal el análisis de la obra cinematográfica de Shadi Abdel Salam. Se trata de uno de los directores árabes de mayor singularidad, aunque su obra completa es prácticamente desconocida para la historiografía occidental. Mediante la recopilación bibliográfica de información referente a su trayectoria biográfica, de diversos textos que examinan sus películas, así como del visionado de su producción cinematográfica, se pone en valor la figura de un director de cine caracterizado por una gran profundidad intelectual y una marcada intencionalidad artística.
A través de sus obras, ambientadas en acontecimientos históricos de distintas épocas, transmite su personalidad artística y su pensamiento en torno al cine. Para Abdel Salam, las imágenes en sí mismas constituyen un elemento artístico, siendo el componente visual lo más importante. Además, concibe el cine como una herramienta de recuperación de un pasado que se encuentra fuera de la memoria histórica, un medio por el cual pueden abrirse profundos debates en el seno de la sociedad egipcia. Abdel Salam ambienta sus películas, bien en el antiguo Egipto, bien en otras etapas históricas, pero con este pasado muy presente, con el objetivo de recuperar el legado sociocultural del pasado faraónico. Este hecho le confiere un carácter único y excepcional, no solo dentro de la cinematografía egipcia, sino también en el seno de la producción árabe
The crowdsourcing data for innovation
Authors: Ilmi Zainal , Wijaya Adi , Kasuma Jati , Darma Dio Caisar 
Published: November 2020

Purpose – to explore a crowdsourcing data-driven approach to construct crowdknowledge databases for innovation through supporting creative idea generation. In the approach, social media will be used as platforms to crowdsource knowledge for producing the databases.
Findings. Creativity is an essential element of innovation, but producing creative ideas is often challenging in design. Many computational tools have become available recently to support designers in producing creative ideas that are new to individuals. As a standard feature, most of the tools rely on the databases employed, such as ConceptNet and the US Patent Database. This study highlighted that the limitations of these databases have constrained the capabilities of the tools and, thereby, new computational databases supporting the generation of new ideas to a crowd or even history are needed. Crowdsourcing outsources tasks conventionally performed in-house to a crowd and uses external knowledge to solve problems and democratize innovation. Social media is often employed in crowdsourcing for a crowd to create and share knowledge.
Originality/value/scientific novelty of the research. This paper proposes a novel approach employing social media to crowdsource knowledge from a crowd for constructing crowd knowledge databases.
Practical importance of the research. The crowd knowledge database is expected to be used by the current computational tools to support designers producing highly creative ideas that are new to the crowd, in new product design, and ultimately to innovation.
Research limitations/Future research. In this study to provide insights and potential directions for future research are discussed that challenges of employing described approach.
Paper type – theoretical.