bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of rosemary herbal extracts (Rosmarinus officinalis) and their potential effects on immunity
Authors: Ahmed Hiwa M. , Babakir‐Mina Muhammed 
Published: February 2020

AbstractThe discovery of new curative drugs and the consumption of natural dietary ingredients with the ability to exhibit immunomodulatory activity is urgently needed to decrease the risk of chronic diseases among the population. Rosmarinus officinalis (Lamiaceae) is an aromatic plant that has been traditionally and medicinally used as a carminative, antispasmodic, painkiller, circulatory tonic, to stimulate hair growth and to improve memory dysfunction. This study aimed to assess the potential effects of rosemary solvent extracts on human immune function. Science Direct, Web of Science, Wiley, Elsevier, PubMed, Scopus, and the Google scholar search engines were used to retrieve relevant information included combinations of “rosemary” or “R. officinalis” with “immune function,” “immunity,” “immune system,” “anti‐inflammatory,” “inflammation,” or “health benefit.” A number of studies have been found a stimulatory effect of rosemary and its active compounds on the immune system in vitro and animal study, but there is a lack of evidence in humans for supporting this. The results demonstrated the potential of rosemary and its main active components as dietary ingredients with immunomodulatory functionality. Human studies should be performed and a double‐blind randomized controlled trial would be ideal.
Asymptotic tracking control for constrained nonstrict‐feedback MIMO nonlinear systems via parameter compensations
Authors: Du Peihao , Pan Yingnan , Chadli Mohammed , Zhao Shiyi 
Published: February 2020

SummaryThis paper studies the problem of adaptive fuzzy asymptotic tracking control for multiple input multiple output nonlinear systems in nonstrict‐feedback form. Full state constraints, input quantization, and unknown control direction are simultaneously considered in the systems. By using the fuzzy logic systems, the unknown nonlinear functions are identified. A modified partition of variables is introduced to handle the difficulty caused by nonstrict‐feedback structure. In each step of the backstepping design, the symmetric barrier Lyapunov functions are designed to avoid the breach of the state constraints, and the issues of overparametrization and unknown control direction are settled via introducing two compensation functions and the property of Nussbaum function, respectively. Furthermore, an adaptive fuzzy asymptotic tracking control strategy is raised. Based on Lyapunov stability analysis, the developed control strategy can effectually ensure that all the system variables are bounded, and the tracking errors asymptotically converge to zero. Eventually, simulation results are supplied to verify the feasibility of the proposed scheme.
Returning to Text: Affect, Meaning Making, and Literacies
Authors: Burnett Cathy , Merchant Guy 
Published: February 2020

AbstractExisting work on literacy and affect has posed important questions for how we think about meanings and how and where they get made. The authors contribute to such work by focusing on the relation between text and affect. This is a topic that has received insufficient attention in recent work but is of pressing concern for education as text interweaves in new ways with human activity, through social media, surveillance capitalism, and artificial intelligence—ways that can be unpredictable and poorly understood. Adopting a sociomaterial sensibility that foregrounds the relations between bodies (people and things), the authors provide conceptual tools for considering how texts affect and are affected by the heterogeneous entanglements from which they emerge. In situating their argument, the authors outline influential readings of Spinoza’s theories of affect, explore how these have been mobilized in literacy research, and identify how text has been accommodated within such research. Using texts from a political episode in the United Kingdom, the authors explore the idea of social‐material‐textual affects to articulate relations among humans, nonhumans, meaning making, and literacies. The authors conclude by identifying four ways in which text participates in what happens, raising questions about how different materializations of text (or indeed “not text”) are significant to the diversifying communicative practices that inflect social, cultural, economic, and political life.
When one door closes, another door opens … for some: Evidence from the post‐TRIPS Indian pharmaceutical industry
Authors: Chattopadhyay Shinjinee , Bercovitz Janet 
Published: February 2020

AbstractResearch SummaryFirms' strategy choices are contextually dependent, yet internally delimited. A radical shift in institutional context forces firms to reevaluate the desirability and suitability of current strategies and assess the potential of new strategic opportunities. From 1970 to 1995, the Indian pharmaceutical industry operated under a process‐focused intellectual property regime and enjoyed legal protection to reverse engineer brand name drugs. In 1995, this protection ended with the introduction of the trade‐related aspects of intellectual property rights (TRIPS) Act. We examine the innovation response of Indian pharmaceutical firms in light of this regime shift focusing on the underlying internal factors influencing firms' strategic choices. We find that the scope and balance of firms' knowledge bases, which set capabilities and influence decision framing, dictate firms' innovative response. We further document how firms' strategic choices contribute to firm financial performance and the reshaping of the Indian pharmaceutical industry.Managerial SummaryFrom 1970 to 1995, the Indian pharmaceutical industry operated under a process‐focused intellectual property regime and enjoyed legal protection to reverse engineer brand name drugs. Following TRIPS in 1995, the intellectual property regime in India became stronger, with product patent enforcement being recognized. Indian pharmaceutical firms had to make strategic choices on the kind of innovation they would pursue under this new IP regime. This article shows that having broad and nonspecialized knowledge assets allowed firms to pursue the most novel innovation and engage in new product development. Having T‐shaped assets, that is, broad knowledge scope yet narrowly focused knowledge expertise, allowed firms to pursue process‐based innovation in areas close to their existing areas of expertise but not necessarily engage in new product development. The findings of this article shed light on what kind of knowledge base and workforce allows firms to adjust to technological and contextual changes.
Enhanced Peltier Effect in Wrinkled Graphene Constriction by Nano‐Bubble Engineering
Authors: Hu Xudong , Gong Xue , Zhang Miao , Lu Huihui , Xue Zhongying , Mei Yongfeng , Chu Paul K. , An Zhenghua , Di Zengfeng 
Published: February 2020

AbstractInspired by the promising applications in thermopower generation from waste heat and active on‐chip cooling, the thermoelectric and electrothermal properties of graphene have been extensively pursued by seeking ingeniously designed structures with thermoelectric conversion capability. The graphene wrinkle is a ubiquitous structure formed inevitably during the synthesis of large‐scale graphene films but the corresponding properties for thermoelectric and electrothermal applications are rarely investigated. Here, the electrothermal Peltier effect from the graphene wrinkle fabricated on a germanium substrate is reported. Peltier cooling and heating across the wrinkle are visualized unambiguously with polarities consistent with p‐type doping and in accordance with the wrinkle spatial distribution. By direct patterning of the nano‐bubble structure, the current density across the wrinkle can be boosted by current crowding to enhance the Peltier effect. The observed Peltier effect can be attributed to the nonequilibrium charge transport by interlayer tunneling across the van der Waals barrier of the graphene wrinkle. The graphene wrinkle in combination with nano‐bubble engineering constitutes an innovative and agile platform to design graphene and other more general two‐dimensional (2D) thermoelectrics and opens the possibility for realizing active on‐chip cooling for 2D nanoelectronics with van der Waals junctions.
Ferrocene and titanocene steroid conjugates: Structures and activities – a brief review
Authors: Dembitsky Valery M. , Gloriozova Tatyana A. , Imbs Andrew B. 
Published: February 2020

AbstractThe present review describes the biological activities of ferrocenes and titanocenes steroid conjugates. Ferrocenes steroid conjugates demonstrate antineoplastic and antihypercholesterolemic activity with a confidence more than 90 percent, and can be used as erythropoiesis‐stimulating agents. Titanocenes steroid conjugates show anti‐inflammatory and anti‐seborrheic activity with a confidence more than 70 percent, and can also be used as glutaconyl‐CoA decarboxylase inhibitors and/or erythropoiesis‐stimulating agents. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review is devoted to synthetic lipids ferrocenes and titanocenes steroid conjugates and their biological activity, which are of great interest for medicine, as well as for pharmacologists and the pharmaceutical industry.
Synthesis of novel artemisinin–triazole hybrids
Authors: Giang Le Nhat Thuy , Anh Dang Thi Tuyet , Phuong Hoang Thi , Thanh Nguyen Ha , Van Tuyen Nguyen 
Published: February 2020

AbstractSeveral substituted triazole–artemisinin hybrids were synthesized based on ‘click’ chemistry between propargyl‐substituted derivatives and artemisinin containing a 2‐hydroxypropane unit. The structures of all obtained compounds were confirmed by means of IR, NMR, and MS spectroscopy. Four new hybrids were evaluated as cytotoxic agents, revealing an interesting anticancer activity of 1‐(4‐(3‐Aminophenyl)‐1H‐1,2,3‐triazol‐1‐yl)‐3‐(((3R,6R,8aS,9R,10S,12R,12aR)‐3,6,9‐trimethyl‐decahydro‐12H‐3,12‐epoxy[1,2]dioxepino[4,3‐i]isochromen‐10‐yl)oxy)propan‐2‐ol compound in KB and HepG2 cancer cell lines.
Bismuth nanodendrites deposited on glassy carbon electrode as a sensitive electrochemical sensor for simultaneous detection of Cd2+ and Pd2+ ions
Authors: Anh Nguyen Hoang , Duy Pham Khac , Yen Pham Thi Hai , Dang Vu Hai , Giao Nguyen Quynh , Ha Vu Thi Thu 
Published: February 2020

AbstractIn this study, bismuth nanodendrites (BiNDs) were fabricated on glassy carbon electrode by chronopotentiometric method. The hierarchical structure and high population matrix of BiNDs provides high surface active area to enhance the electrochemical signals of measured Cd2+ and Pb2+ ions. The developed bismuth nanodendritic structure was well‐observed and characterzied by scanning electron microscopy (SEM). Electrochemical behaviours of developed BiNDs electrodes were studied by the cyclic voltammetric (CV) method. The fabrication conditions for BiNDs such as the applied current and deposition time were optimized as ‐10 mA and 90 s, respectively. Under this optimized condition, the highest peaks of Cd2+ and Pb2+ ions at concentration of 20 ppb were obtained. The Cd2+ and Pb2+ signals acquired by BiNDs are almost three times greater than that measured by the Bi film electrode.
Synthesis of tantalum oxynitride with enhanced visible light efficiency in photoreduction of carbon dioxide
Authors: Le Chi Nguyen Thi Phuong , Tung Mai Hung Thanh , Van Hoang Cao , Cam Nguyen Thi Dieu , Thu Nguyen Thi Minh , Phuong Tran Thi Thu , Phuong Nguyen Minh , Van Noi Nguyen 
Published: February 2020

AbstractThe tantalum oxynitride (TaON) content in preparation process was increased with the melamine and tantalum pentoxide (Ta2O5) mass ratios. The Ta2O5 nitridation by melamine (C3H6N6) was occured in at 850 °C for 4 hours with various melamine and tantalum pentoxide mass ratios under a nitrogen gas flow. The photocatalytic performance of prepared samples was evaluated by the photoreduction of carbon dioxide into renewable fuel under visible light irradiation. Results show that the obtained photocatalysts exhibited a significant enhanced photocatalytic activity in comparison with pure Ta2O5. This work may be useful for a facile way to synthesize the highly efficient photocatalyst for application in energy conversion.
Chemical constituents of MeOH extract from the fruits of Macaranga sampsonii
Authors: Quynh Do Thi , Vu Le Tran Nguyen , Huong Doan Thi Mai , Ngan Truong Bich , Hue Nguyen Thi , Thach Tran Dang , Van Cuong Pham 
Published: February 2020

AbstractThe genus Macaranga belongs to the family Euphorbiaceaeconsistingof about 300 species that are mainly distributed inthe tropics of Africa, Asia, Australia, and the Pacific regions. Thirteen different species of this genus occur in Viet Nam, and Macaranga sampsonii has been used in traditional medicine to treat swellings, cuts, sores. Phytochemical investigation of the methanol extract of Macaranga sampsonii led to the isolation of six compounds including: boehmenan X (1), maltol β‐D‐glucopyranoside (2), methyl brevifolincarboxylate (3), scopoletin (4), 3,5‐dihydroxy‐4‐methoxy benzoic acid (5) and gallic acid (6). Their structures were confirmed by spectroscopic methods including IR, MS, 1D, 2D NMR and compared to previous reported spectral data values.
Study of water disinfection by analyzing the ozone decomposition process
Authors: Nghi Nguyen Hoang , Cuong Le Cao , Dieu Tran Vinh , Oanh Doan Thi Yen 
Published: February 2020

AbstractPossessing high binding energy, molecular ozone (O3) is not stable and spontaneously breaks down into oxygen especially at high temperature. It is called thermal decomposition of ozone. On other hand, ozone with high redox potential (2.06 V) is considered to be a powerful oxidant. In water ozone reacts with both of inorganic and organic substances. Interaction of ozone with the matters consumes an amount of ozone dissolved in water. So by analysing the ozone decomposition curves, we can measure and calculate the reaction rate R, rate constant k, the half‐life time and reaction order of the ozone reaction with the matters. These parameters indicate the disinfection ability of ozone and its mechanism. Calculated value of half‐life time can be used to estimate the water quality and the water disinfection level.
Facile synthesis of urchin‐like gold nanoparticles using binary reducing agent composed of EDTA and hydroquinone
Authors: Nhat Hang Nguyen Thi , Phuong Phong Nguyen Thi 
Published: February 2020

AbstractUrchin‐like gold nanoparticles (U‐AuNPs) were successfully synthesized through a rapid one‐pot seedless growth process. This method was carried out by using the combination of ethylenediaminetetraacetic acid (EDTA) and hydroquinone (HQ) as reducing agents. The effect of order of agents addition to the particle size was investigated. The obtained urchin‐like gold nanoparticles (NPs) were characterized by XRD, TEM and UV‐Vis absorption spectroscopy techniques. From the TEM analysis, it was found with different sizes of urchin‐like gold nanoparticles from 55 to 102 nm.
The synthesis and characterization of high purity mixed microporous/mesoporous activated carbon from rice husk
Authors: Tung Mai Thanh , Luong Vu Duc , Trang Pham Minh , Van Tuyen Le , Bich Thuy Hoang Thi , Wu Nae‐Lih 
Published: February 2020

AbstractRice husk (RH) is one of the most earth abundant, low‐cost, and ecofriendly agricultural residues. In this study, we successfully synthesized activated carbon from rice husk (RHAC) through carbonizing the rice husk and activating chemical by K2CO3. The effect of carbonization and activation temperature was investigated. At temperature of 800°C, activated carbon was obtained with high surface area of 1583 m2.g‐1 and pore volume of 0.93 cm3.g‐1. These results suggest that the earth‐abundant RH could be sustainable resources for large‐scale production of activated carbon.
Synthesis and in vitro antifungal efficiency of alginate‐stabilized Cu2O‐Cu nanoparticles against Neoscytalidium dimidiatum causing brown spot disease on dragon fruit plants (Hylocereus undatus)
Authors: Du Bui Duy , Ngoc Doan Thi Bich , Thang Nguyen Duy , Tuan Le Nghiem Anh , Thach Bui Dinh , Hien Nguyen Quoc 
Published: February 2020

AbstractCu2O‐Cu nanoparticles (Cu2O‐Cu NPs) stabilized by alginate have been developed for using as a plant fungicide. The antifungal effect of Cu2O‐Cu NPs against Neoscytalidium dimidiatum fungus causing brown spot disease in dragon fruit plants was investigated. Transmission electron microscopy (TEM) was used to assess the morphology and size of Cu2O‐CuNPs. The average diameter of spherical Cu2O‐Cu NPswas determined to be 5.4 ± 0.4 nm. Furthermore, the Cu2O‐CuNPs stabilized in alginate were also characterized by Fourier transform infrared (FT‐IR) and X‐ray diffraction (XRD) analysis. Especially, the prepared Cu2O‐Cu NPs/alginate showed high antifungal efficiency (~100 %) against Neoscytalidium dimidiatum with 30 ppm concentration copper. The obtained results showed that Cu2O‐Cu NPs stabilized in alginate have great potential in the development of nanomaterials for plant fungicide applications.
Synthesis of Valsartan as drug for the treatment of hypertension
Authors: Van Chien Tran , Anh Nguyen The , Thao Tran Thi Phuong , Phuong Le Dac , Tham Pham Thi , Tung Nguyen Quang , Van Loc Tran 
Published: February 2020

AbstractThe synthesis of valsartan (1), one of the most currently used pharmaceutical agent in antihypertensive therapy, was described through five steps in an overall yield of 54 % starting from 4’‐methyl‐2‐cyanobiphenyl (2). The key step involved tetrazole ring formation catalyzed by Lewis acid. The structures of synthesized compounds were confirmed by means of NMR and MS spectroscopíe.
Study on the effect of modified and unmodified silica on the properties of natural rubber vulcanizates
Authors: Quang Nguyen Trong , Hung Dang Viet , Chuong Bui , Nam Hoang , Yen Nguyen Thi 
Published: February 2020

AbstractIn the article, the effects of silica (silicon oxide) on some properties of natural rubber (NR) were studied. Silica used are unmodified (SiKBT) and modified with triethoxi silane propyl tetrasunfite (SiBT). It is shown SiBT increases vulcanization network density (VND), so it enhances strength and elastic properties of NR. In contrary, SiKBT decreases VND and reduces, but has almost no effect on strength of NR. Silica, both modified and unmodified, are assumed to improve network regularity of NR that change thermal degradation behavior of materials and keep the strength of NR‐SiKBT compound unchanged.
Electrochemical properties of antimony lead electrode in gelled electrolyte prepared by liquid glass and sulfuric acid using polyacrylamide together with polyaniline
Authors: Binh Phan Thi , Van Anh Nguyen Thi , Thuy Mai Thi Thanh , Xuan Mai Thi , Thanh Luong Thi 
Published: February 2020

AbstractGelled electrolyte is made at different temperatures based on liquid glass and sulfuric acid using two organic additives such as polyacrylamide and polyaniline. The antimony lead electrode is used to study the electrochemical properties of gelled electrolyte through cyclic voltammetry, electrochemical impedance and ionic conductivity determination. The results showed that the gelled electrolyte made at low temperature is in a more favorable form of gel than that at high temperature, the ability to extract water was also overcome. The resistance of charge transfer of lead electrodes operating in an gelled electrolyte environment is all lower than that in sulfuric acid (d = 1.26 g /cm3), in which the presence of PANi together with PAM is recorded as the smallest. When the lead electrode was anodized, the simultaneous formation of PbO with PbSO4 did not appear due to the presence of PANi.
An insight QSPR‐based prediction model for stability constants of metal‐thiosemicarbazone complexes using MLR and ANN methods
Authors: Quang Nguyen Minh , Nhung Nguyen Thi Ai , Van Tat Pham 
Published: February 2020

AbstractIn the present investigation, the stability constants (logβ12) of complexes (ML2) between metal ions (M) and thiosemicarbazones (L) were used as an endpoint in the quantitative structure‐property relationship (QSPR) approaches. The molecular descriptors of the experimental complexes were calculated from the conformation with the lowest binding free energy by means of semi‐empirical PM7 method. QSPR models were developed by using multivariate linear regression (MLR) and artificial neural network methods (ANN). The best QSPR models found out three important descriptors as knotp, Cosmo Area and Hmin in the metal‐thiosemicarbazones complexation. The final QSPRMLR model had shown satisfactory statistical performance; training (R2train) and prediction (Q2LOO) determination coefficient of 0.9274 and 0.8784, respectively. Meanwhile, the statistical results of QSPRANN model received the value of 0.9844 and 0.9898. The models also ratified strict statistical validation tests (Q2test) for external predictivity with the QSPRMLR and QSPRANN value of 0.8321 and 0.8953, respectively. A series of new metal‐thiosemicarbazones complexes were designed based on the descriptor of the models and predicted the stability constants of the complexes.
Theoretical exploitation of donor‐acceptor ability in low‐valent group‐14 elements complexes [E(PPh3)2 → SiH2]2+ (E = C to Pb) using energy decomposition analysis
Authors: Loan Huynh Thi Phuong , Van Duc Hoang , Quang Duong Tuan , Cong Vo Thanh , Van Tat Pham , Trung Nguyen Tien , Nhung Nguyen Thi Ai 
Published: February 2020

AbstractThe structure and bonding of complexes containing subvalent group‐14 elements [E(PPh3)2 → SiH2]2+ (Si‐EP) with E = C to Pb have been researched using charge‐ and EDA‐NOCV methods. The optimized equilibrium geometries for complexes have the most stable structure which has been found for carbone ligand CP as the nearly end‐on bonded form in Si‐CP. In contrast to this, the heavier ligands SiP to PbP in the heavier complexes Si‐SiP to Si‐PbP exhibit strongly side‐on manners. Bond dissociation energies, ‐De (kcal.mol‐1), increase from Si‐CP to the stronger bonded complexes Si‐SiP to Si‐PbP. EDA‐NOCV calculations revealed that the donation [E(PPh3)2 → SiH2]2+ displays the significant σ‐interactions of the ligands while the π‐electron sharing exhibits the charges transfer between E(PPh3)2 and SiH22+. Bonding analysis indicated that the Si‐E bond results from the decrease in the donation [E(PPh3)2 → SiH2]2+ and electrostatic attraction. The investigated complexes possessed E(PPh3)2 → SiH22+ strong σ‐donors and E(PPh3)2 ↔ SiH22+ π‐π electrons shared between the two fragments.
Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α‐glucosidase inhibitory activities
Authors: Truc Duong Thi Thanh , Vy Cao Thi Ha , Phu Dang Hoang , Hoang Nguyen Minh , Nhan Nguyen Trung 
Published: February 2020

AbstractSix lupan‐type triterpenoids: 29‐norlupan‐3,20‐dione (1), 3β‐hydroxy‐29‐norlupan‐20‐one (2), betulonic acid (3), salacianol (4), 30‐hydroxylup‐20(29)‐en‐3‐one (5), and lup‐20(29)‐ene‐3β,30‐diol (6) have been isolated from the CHCl3‐soluble fraction of the stem of Salacia chinensis L. (Celastraceae). Their chemical structures were elucidated based on the NMR spectroscopic analysis and comparison with the literatures. Compounds (5) and (6) showed very weak α‐glucosidase inhibitory activity with the IC50 values of 211.5 and 246.8 μM, respectively.