bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membangun Peradaban Sufistik melalui Hermeneutika Schleiermacher pada Ekspresi-Ekspresi Sejarah Perjuangan Imam Husain
Authors: Rahman Fadhlu , Darmawan Dicky 
Published: July 2020

<p class="06IsiAbstrak">The modern western perspective initiated by the renaissance and the enlightenment century successfully couped the reality of God. This was carried out by some western intellectuals and thinkers, which ultimately gave obscurity to the human concept. The obscurity of this concept then has implications for the meaning of the progress of human civilization. This further gives serious problems to almost the entire social order. Husain's struggle as the eternal history of humanity interpreted through Hermeneutics Scheleiermacher provides another perspective on human concepts and the progress of civilization. The monotheistic values they contain glance at the sides of spirituality as a measure of the progress of civilization. From it the definition of civilization gained new space and paved the way for human potentials that were inherently the cornerstone of the progress of civilization. This paper tries to uncover the values of Imam Husain's struggle in Karbala which is interpreted through Schleiermacher's psychological and grammatical interpretation and contextualizes it with the concept of Coomaraswamy spiritual civilization, as a foundation for the meaning of civilization using historical and descriptive analysis methods. So that the paradigm of the progress of civilization gets an alternative new perspective, and spirituality can be used as a measure of the progress of civilization.</p>
Public trust and Global Biobank Networks
Authors: Dive Lisa , Critchley Christine , Otlowski Margaret , Mason Paul , Wiersma Miriam , Light Edwina , Stewart Cameron , Kerridge Ian , Lipworth Wendy 
Published: July 2020

Abstract
Background: Biobanks provide an important foundation for genomic and personalised medicine. In order to enhance their scientific power and scope, they are increasingly becoming part of national or international networks. Public trust is essential in fostering public engagement, encouraging donation to, and facilitating public funding for biobanks. Globalisation and networking of biobanking may challenge this trust. Methods: We report the results of an Australian study examining public attitudes to the networking and globalisation of biobanks. The study used quantitative and qualitative methods in conjunction with bioethical analysis in order to determine factors that may contribute to, and threaten, trust.Results: Our results indicate a generally high level of trust in biobanks and in medical research more broadly. Key factors that can reduce perceived trustworthiness of biobanks are commercialisation and involvement in global networking. Conclusions: We conclude that robust ethical oversight and governance standards can both promote trust in global biobanking and ensure that this trust is warranted.
De novo assembly and transcriptome characterization of an endemic species of Vietnam, Panax vietnamensis Ha et Grushv., including the development of EST-SSR markers for population genetics
Authors: Vu Duy Dinh , Shah Syed Noor Muhammad , Pham Mai Phuong , Bui Van Thang , Nguyen Minh Tam , Nguyen Thi Phuong Trang 
Published: July 2020

Abstract
Background: Understanding the genetic diversity in endangered species that occur in forest remnants is necessary to establish efficient strategies for the species conservation, restoration and management. Panax vietnamensis Ha et Grushv. is medicinally important, endemic and endangered species of Vietnam. However, genetic diversity and structure of population are unknown due to lack of efficient molecular markers. Results: In this study, we employed Illumina HiSeqTM 4000 sequencing to analyze the transcriptomes of P. vietnamensis (roots, leaves and stems). Raw reads total of 23,741,783 was obtained and then assembled, from which the generated unigenes were 89,271 (average length = 598.3191 nt). The 31,686 unigenes were annotated in different databases i.e. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Nucleotide Collection (NR/NT) and Swiss-Prot for functional annotation. Further, 11,343 EST-SSRs were detected. From 7,774 primer pairs, 101 were selected for polymorphism validation, in which; 20 primer pairs were successfully amplified to DNA fragments and significant amounts of polymorphism was observed within population. The nine polymorphic microsatellite loci were used for population structure and diversity analyses. The obtained results revealed high levels of genetic diversity in populations, the average observed and expected heterozygosity were HO = 0.422 and HE = 0.479, respectively. During the Bottleneck analysis using TPM and SMM models (p < 0.01) shows that targeted population is significantly heterozygote deficient. This suggests sign of the bottleneck in all populations. Genetic differentiation between populations was moderate (FST = 0.133) and indicating slightly high level of gene flow (Nm = 1.63). Analysis of molecular variance (AMOVA) showed 63.17% of variation within individuals and 12.45% among populations. Our results shows two genetic clusters related to geographical distances. Conclusion: Our study will assist conservators in future conservation management, breeding, production and habitats restoration of the species.
Reliability of Tibiofemoral Contact Area and Centroid Location in an Upright, Open MRI (UO-MRI)
Authors: Schmidt Andrew , Stockton David J. , Hunt Michael A. , Yung Andrew , Masri Bassam A. , Wilson David R. 
Published: July 2020

Abstract
Background: Biomechanical studies are often performed using conventional closed-bore MR, which has necessitated simulating weightbearing load on the joint. The clinical applicability of these biomechanical findings is unclear because of the limitations of simulating weightbearing. Upright, open MRI (UO-MRI) can be used to assess knee joint mechanics, in particular contact area and centroid location. However, it is not clear how reliably measurements of contact area and centroid location can be made in upright weightbearing postures. Methods: Manual segmentation of cartilage regions in contact was performed and centroids of those contact areas were automatically determined for the medial (MC) and lateral (LC) tibiofemoral compartments. To assess reliability, inter-rater, test-retest, and intra-rater reliability were determined by intra-class correlation (ICC 3,1 ), standard error of measurement (SEM), smallest detectable change with 95% confidence (SDC 95 ). Accuracy was assessed by using a high-resolution, 7T MRI as a reference and determined by measurement error (%). Results: Contact area and centroid location reliability (inter-rater, test-retest, and intra-rater) for sagittal scans in the MC demonstrated ICC 3,1 values from 0.95-0.99 and 0.98-0.99 respectively, and in the LC from 0.83-0.91 and 0.95-1.00 respectively. The smallest detectable change in contact area was 1.28% in the MC and 0.95% in the LC. Contact area and centroid location reliability for coronal scans in the MC demonstrated ICC 3,1 values from 0.90-0.98 and 0.98-1.00 respectively, and in the LC from 0.76-0.94 and 0.93-1.00 respectively. The smallest detectable change in contact area was 0.65% in the MC and 1.41% in the LC. Contact area segmentation was accurate to within 4.81% measurement error. Conclusions: Knee contact area and contact centroid location can be assessed in upright weightbearing MRI with good to excellent reliability and accuracy within 5%. The lower field strength used in upright, weightbearing MRI does not compromise the reliability of tibiofemoral contact area and centroid location measures.
Liver fibrosis assessments using FibroScan, Virtual-Touch tissue quantification, the FIB-4 index, and Mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection
Authors: Ueda Naoyuki , Kawaoka Tomokazu , Imamura Michio , Aikata Hiroshi , Nakahara Takashi , Murakami Eisuke , Tsuge Masataka , Hiramatsu Akira , HAYES C.NELSON , Yokozaki Michiya , Chayama Kazuaki 
Published: July 2020

Abstract
Background and purpose: Viral infection promotes fibrosis through repeated regeneration of hepatocytes. Evaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several limitations. The aim of this study was to determine correlations among METAVIR scores and FibroScan, Virtual-Touch tissue quantification (VTQ), fibrosis index based on four factors (FIB-4 index), and Mac-2 binding protein glycosylation isomer (M2BPGi) level in order to examine differences in the reliability of non-invasive methods to evaluate fibrosis.Methods: We used liver resection specimens from patients with hepatitis C virus (HCV). Correlations were assessed between METAVIR scores and non-invasive method. Receiver operating characteristic (ROC) curves were generated to determine the sensitivity, specificity, and cut off values of the methods.Results: Correlations between METAVIR scores and the results of each method were as follows: FibroScan r=0.61 p≤0.001; VTQ r=0.64, p≤0.001; FIB-4 index r=0.40, p≤0.001; and M2BPGi r=0.32, p=0.01. In comparing ROC curves, there were significant differences between FibroScan and FIB-4 index; FibroScan and M2BPGi in the F0-1vs F2-4 group; VTQ and FIB-4 index; FibroScan and FIB-4 index; FibroScan and M2BPGi in the F0-2 and F3-4 group; VTQ and FIB-4 index; FibroScan and FIB-4 index; FibroScan and M2BPGi; and VTQ and M2BPGi in the F0-3 vs F4 group. Results in the non-sustained viral response (SVR) group were as follows: FibroScan r=0.65, p≤0.001; VTQ r=0.70, p≤0.001; FIB-4 index r=0.44, p≤0.001; and M2BPGi r=0.31, p=0.01, with significant differences with respect to VTQ vs FIB-4 index, FibroScan vs FIB-4 index, FibroScan vs M2BPGi, VTQ vs M2BPGi in the F0-2 vs F3-4 group, VTQ vs FIB-4 index, FibroScan vs FIB-4 index, FibroScan vs M2BPGi, and VTQ vs M2BPGi in the F0-3 vs F4 group.The following correlations were found in the SVR group: FibroScan r=0.58, p≤0.001; VTQ r=0.65, p≤0.001; FIB-4 index r=0.59, p≤0.001; and M2BPGi r=0.54, p≤0.001, with significant differences with respect to FibroScan vs VTQ, FibroScan vs FIB-4 index, FibroScan vs M2BPGi in the F0-1 vs F2-4 group, and FibroScan vs FIB-4 index in the F0-3 vs F4 group.Conclusions: FibroScan and VTQ best reflected the results of hepatic fibrosis diagnosis using liver resection specimens among the four examination methods evaluated.
Shenmai injection alleviates acute lung injury in a severe acute pancreatitis rat model via heme oxygenase-1 upregulation
Authors: Zhang Fei-hu , Hao Hao , Liu Yang , Fan Kai-liang , Dai Wen , Liu Wei-hong , Kong Li 
Published: July 2020

Abstract
Background: To determine the effect of Shenmai injection (SMI) on acute lung injury (ALI) induced by severe acute pancreatitis (SAP) in rats. Methods: Forty male Sprague-Dawley (SD) rats were grouped into 4 categories: SAP group, sham surgery (SS) group, SAP + SMI group, SAP + SMI + Zinc protoporphyrin (ZnPP) group. Rats in the SAP group were intravenously injected with 1.6 ml/kg saline 30 minutes after induction of SAP models. Rats in the SAP + SMI group were intravenously injected with 1.6 ml/kg SMI, while those in the SAP + SMI + ZnPP group rats were intravenously injected with 1.6 ml/kg SMI and 30 mg/kg ZnPP via intraperitoneal injection. Twenty-four hours after SAP induction, the rats were sacrificed. Excised lung tissues were histologically examined, protein concentration in bronchoalvelar lavage fluid (BALF) was measured and lung wet-to-dry (W/D) weight ratio was calculated. The protein and mRNA levels of the tumor necrosis factor (TNF) -α, heme oxygenase (HO) -1 and interleukin (IL) -10 in blood and tissue samples were measured.Results: SMI treatment attenuated SAP-induced ALI as evidenced by lower scores of lung damage compared with untreated SAP group (p＜0.05). SMI also abolished the SAP-induced rise in BALF and W/D ratio protein concentrations (p＜0.05). Moreover, SMI treatment increased HO-1, IL-10 levels but decreased TNF-α level in serum and tissue samples (p＜0.05). However, inhibition of HO-1 expression by ZnPP led to significant inhibition of all the changes.Conclusions: SMI can alleviate SAP-induced ALI through HO-1 upregulation.
Viewing an alpine environment positively affects emotional analytics in patients with somatoform, depressive and anxiety disorders as well as in healthy controls
Authors: Hüfner Katharina , Ower Cornelia , Kemmler Georg , Vill Theresa , Martini Caroline , Schmitt Andrea , Sperner-Unterweger Barbara 
Published: July 2020

Abstract
Background: Patients with somatoform, depressive or anxiety disorders often don´t respond well to medical treatment and experience many side effects. It is thus of clinical relevance to identify alternative, scientifically based, treatments. Our approach is based on the recent evidence that urbanicity has been shown to be associated with an increased risk for mental disorders. Conversely, green and blue environments show a dose-dependent beneficial impact on mental health. Methods: Here we evaluate the effect of viewing stimuli of individuals in an alpine environment on emotional analytics in 183 patients with psychiatric disorders (mostly somatoform, depressive and anxiety disorders) and 315 healthy controls (HC). Emotional analytics (valence: unhappy vs happy, arousal: calm vs excited, dominance: controlled vs in control) were assessed using the Self-Assessment Manikin. Further parameters related to mental health and physical activity were recorded.Results: Emotional analytics of patients indicated that they feel less happy, less in control and had higher levels of arousal than HC when viewing neutral stimuli. The comparison alpine>neutral stimuli showed a significant a positive effect of alpine stimuli on emotional analytics in both groups. Patients and HC both felt attracted to the scenes displayed in the alpine stimuli. Emotional analytics correlated positively with resilience and inversely with perceived stress.Conclusions: Preventive and therapeutic programs for patients with somatoform, depressive and anxiety disorders should consider taking the benefits of natural outdoor environments such as alpine environments, into account. Organizational barriers which are preventing the implementation of such programs in clinical practice need to be identified and addressed.
Differences in Achilles tendon stiffness in people with gout.
Authors: Otter Simon , Catherine Payne , Anna-Marie Jones , Nick Webborn , Peter Watt 
Published: July 2020

Abstract
Background Gout has been associated with weaker foot/leg muscles and altered gait patterns. There is also evidence of on-going foot pain and an increased risk of tendinopathy, with the Achilles and patellar tendons most frequently affected in gout. Additionally, the inflammation associated with gout may change tissue elasticity. Ultrasound imaging utilising shear wave elastography (SWE) offers a non-invasive method of quantifying changes in tendon stiffness. SWE findings have not previously been reported in individuals with gout. We sought to determine differences in Achilles tendon stiffness in people with gout compared to controls (non-gout). Methods: A cross sectional study comparing 24 people with gout and 26 age/sex-matched controls. Clinical and demographic data were collated, and US imaging used to determine tendon thickness, presence of gouty tophi and/or aggregates and levels of angiogenesis. Ten shear wave elastography (SWE) measures were taken along the centre of a longitudinal section of the mid-portion of each Achilles tendon. Prior to data collection, intra-observer error was good (0.75). Data were summarised using descriptive statistics and a repeated measures ANCOVA was used to compare SWE measures between the two groups for the left and right foot separately after accounting for Body Mass Index (BMI). Results: A small proportion of those with gout presented with intra-tendon aggregates and/or intra-tendon tophi in one or both tendons. There was no statistically significant difference in tendon thickness between groups. Neo-vascularity was present in a third of gout participants. SWE findings demonstrated significantly reduced tendon stiffness in those with gout compared to controls: right Achilles mdiff =1.04m/s (95% CI (0.38 to 1.7) p=0.003 and left Achilles mdiff = 0.7m/s (95% CI 0.09 to 1.32) p=0.025. No relationship between the presence of tophi and SWE values were detected. Conclusion: Subjects with chronic gout show significantly reduced Achilles tendon stiffness compared to non-gout controls. From a clinical standpoint, our findings were similar to SWE measurements in subjects with Achilles tendinopathy and who did not have gout.
Identification of an immune gene signature for predicting the prognosis of patients with uterine corpus endometrial carcinoma
Authors: Zhou Cankun , Li Chaomei , Yan Fangli , Zheng Yuhua 
Published: July 2020

Abstract
Background: Uterine corpus endometrial carcinoma (UCEC) is a frequent gynecological malignancy with a poor prognosis especially when at an advanced stage. In the present study, we explored the potential of an immune-related gene signature to predict overall survival in UCEC patients.Methods: We analyzed expression data of 616 UCEC patients from The Cancer Genome Atlas database and the International Cancer Genome Consortium as well as immune genes from the ImmPort database and identified the signature. We constructed a transcription factor regulatory network based on Cistrome databases and performed functional enrichment and pathway analyses for the differentially expressed immune genes. Moreover, the prognostic value of 410 immune genes was determined using Cox regression analysis then constructed a prognostic model. Finally, we performed immune infiltration analysis using TIMER-generating immune cell content.Results: Results indicated that the immune cell microenvironment as well as the PI3K-Akt, and MARK signaling pathways were involved in UCEC development. The established prognostic model revealed a ten-gene prognosis signature , comprising PDIA3, LTA, PSMC4, TNF, SBDS, HDGF, HTR3E, NR3C1, PGR, and CBLC . This can be used as an independent tool to predict the prognosis of UCEC owing to the observed risk-score. In addition, levels of B cells and neutrophils were significantly correlated with the patient's risk score, and the expression of ten genes is associated with immune cell infiltrates.Conclusions: In summary, we present a 10-gene signature with the potential to predict the prognosis of UCEC. This is expected to guide future development of individualized treatment approaches.
Spatiotemporal characteristics and the epidemiology of tuberculosis from 2004 to 2017 in China by the nationwide surveillance system
Authors: Zuo Zhongbao , Wang Miaochan , Cui Huaizhong , Wang Ying , Wu Jing , Qi Jianjiang , Pan Kenv , Sui Dongming , Liu Pengtao , Xu Aifang 
Published: July 2020

Abstract
Background

The objective was to identify the Spatial-temporal characteristics and the epidemiology of tuberculosis in China from 2004 to 2017 with Joinpoint regression analysis, Seasonal Autoregressive integrated moving average (SARIMA) model, geographic cluster, and multivariate time series model.

Methods

The data of TB from January 2004 to December 2017 were obtained from the notifiable infectious disease reporting system supplied by the China CDC. Joinpoint regression analysis was used to observe the trend. The monthly incidence was predicted by the Seasonal autoregressive integrated moving average (SARIMA) model. Spatial autocorrelation analysis was performed to detect geographic clusters. A multivariate time series model was employed to analyze heterogeneous transmission.

Results

We included 13,991,850 TB cases from 2004 to 2017. The final selected model was the 0 Joinpoint model with an annual average percent change of -3.3. A seasonality was observed across the fourteen years, and the seasonal peaks were in January and March. The best SARIMA model was (0, 1, 1) X (0, 1, 1) 12 , with a minimum AIC (880.5) and SBC (886.4). The predicted value and the original incidence data of 2017 were well matched. The provinces with a high incidence were located in the northwest (Xinjiang, Tibet) and south (Guangxi, Guizhou, Hainan) of China. The autoregressive component had a leading role in the incidence of TB which accounted for 81.5% - 84.5% of the patients on average. The endemic component was about twice as large in the western provinces as the average while the spatial-temporal component was less important there. Most of the high incidences areas were mainly affected by the autoregressive component for the past fourteen years.

Conclusion

A significant decreasing trend was seen from 2004 to 2017. The seasonal peaks were in January and March every year. Obvious clusters were identified in Tibet and Xinjiang Province. A spatial heterogeneity in the component driving the transmission of TB was identified from the multivariate time series model. This suggested that targeted preventive efforts should be made in different provinces based on the main component contributing to the epidemics.