bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of cardiopulmonary exercise testing in cardiac amyloidosis
Authors: Nicol Martin , Deney Antoine , Lairez Olivier , Vergaro Giuseppe , Emdin Michele , Carecci Alessandro , Inamo Jocelyn , Montfort Astrid , Neviere Remi , Damy Thibaud , Harel Stephanie , Royer Bruno , Baudet Mathilde , Cohen‐Solal Alain , Arnulf Bertrand , Logeart Damien 
Published: October 2020

AimsIn amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA).Methods and resultsWe carried out a multicentre study including patients with light chain (AL) or transthyretin (TTR) CA. All patients underwent exhaustive examination including CPET and follow‐up. The primary prognostic endpoint was the occurrence of death or heart failure hospitalization. Overall, 150 patients were included (91 AL and 59 TTR CA). Median age, systolic blood pressure, N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) and cardiac troponin T were 70 (64–78) years, 121 [interquartile range (IQR) 109–139] mmHg, 2806 (IQR 1218–4638) ng/L and 64 (IQR 33–120) ng/L, respectively. New York Heart Association classes were I–II in 64%. Median peak oxygen consumption (VO2) and circulatory power were low at 13.0 (10.0–16.9) mL/kg/min and 1730 (1318–2614) mmHg/mL/min, respectively. The minute ventilation/carbon dioxide production slope was increased to 37 (IQR 33–45). A total of 77 patients (51%) had chronotropic insufficiency. After a median follow‐up of 20 months, there were 37 deaths and 44 heart failure hospitalizations. At multivariate Cox analysis, peak VO2 ≤13 mL/kg/min [hazard ratio (HR) 2.7, 95% confidence interval (CI) 1.6–4.8], circulatory power ≤1730 mmHg/mL/min (HR 2.4, 95% CI 1.2–4.6) and NT‐proBNP ≥1800 ng/L (HR 2.2, 95% CI 1.1–4.3) were found to be associated with the primary outcome. No events occurred in patients with both peak VO2 >13 mL/kg/min and NT‐proBNP <1800 ng/L, while the association of VO2 ≤13 mL/kg/min with NT‐proBNP ≥1800 ng/L identified a very high‐risk subgroup.ConclusionIn CA, CPET is helpful in assessing functional capacity, circulatory and chronotropic responses as well as the prognosis of patients along with cardiac biomarkers.
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers
Authors: Karatas Omer Faruk , Capik Ozel , Barlak Neslisah , Aydin Karatas Elanur 
Published: October 2020

AbstractBackgroundMajor milestones of head and neck carcinogenesis have been associated with various genetic abnormalities; however, a clear picture of the molecular networks deregulated during the carcinogenesis of head and neck squamous cell carcinoma (HNSC) has not yet completely revealed.MethodsIn this study, we used in silico tools and online data sets to evaluate the underlying reasons for the expressional changes of genes residing within the chromosome 3q and to help understanding their contributions to HNSC carcinogenesis.ResultsWe found that 13 of 20 most upregulated genes in HNSC are localized to 3q. Further analysis revealed a gene signature consisting of DHX36, OPA1, and SENP2, which showed significant correlation in HNSC samples and potentially be deregulated through similar mechanisms including DNA amplification, transcriptional, and posttranscriptional regulation.ConclusionsConsidering our findings, we suggest DHX36, OPA1, and SENP2 genes as overexpressed in HNSC tumors and that might be concurrently involved in HNSC carcinogenesis, tumor progression, and induction of angiogenic pathways.
Analysis of Survival Benefits of Living Versus Deceased Donor Liver Transplant in High Model for End‐Stage Liver Disease and Hepatorenal Syndrome
Authors: Wong Tiffany Cho‐Lam , Fung James Yan‐Yue , Pang Herbert H. , Leung Calvin Ka‐Lam , Li Hoi‐Fan , Sin Sui‐Ling , Ma Ka‐Wing , She Brian Wong‐Hoi , Dai Jeff Wing‐Chiu , Chan Albert Chi‐Yan , Cheung Tan‐To , Lo Chung‐Mau 
Published: October 2020

Background and Aims
Previous recommendations suggested living donor liver transplantation (LDLT) should not be considered for patients with Model for End‐Stage Liver Disease (MELD) > 25 and hepatorenal syndrome (HRS).

Approach and Results
Patients who were listed with MELD > 25 from 2008 to 2017 were analyzed with intention‐to‐treat (ITT) basis retrospectively. Patients who had a potential live donor were analyzed as ITT‐LDLT, whereas those who had none belonged to ITT‐deceased donor liver transplantation (DDLT) group. ITT‐overall survival (OS) was analyzed from the time of listing. Three hundred twenty‐five patients were listed (ITT‐LDLT n = 212, ITT‐DDLT n = 113). The risk of delist/death was lower in the ITT‐LDLT group (43.4% vs. 19.8%, P < 0.001), whereas the transplant rate was higher in the ITT‐LDLT group (78.3% vs. 52.2%, P < 0.001). The 5‐year ITT‐OS was superior in the ITT‐LDLT group (72.6% vs. 49.5%, P < 0.001) for patients with MELD > 25 and patients with both MELD > 25 and HRS (56% vs. 33.8%, P < 0.001). Waitlist mortality was the highest early after listing, and the distinct alteration of slope at survival curve showed that the benefits of ITT‐LDLT occurred within the first month after listing. Perioperative outcomes and 5‐year patient survival were comparable for patients with MELD > 25 (88% vs. 85.4%, P = 0.279) and patients with both MELD > 25 and HRS (77% vs. 76.4%, P = 0.701) after LDLT and DDLT, respectively. The LDLT group has a higher rate of renal recovery by 1 month (77.4% vs. 59.1%, P = 0.003) and 3 months (86.1% vs, 74.5%, P = 0.029), whereas the long‐term estimated glomerular filtration rate (eGFR) was similar between the 2 groups. ITT‐LDLT reduced the hazard of mortality (hazard ratio = 0.387‐0.552) across all MELD strata.

Conclusions
The ITT‐LDLT reduced waitlist mortality and allowed an earlier access to transplant. LDLT in patients with high MELD/HRS was feasible, and they had similar perioperative outcomes and better renal recovery, whereas the long‐term survival and eGFR were comparable with DDLT. LDLT should be considered for patients with high MELD/HRS, and the application of LDLT should not be restricted with a MELD cutoff.
Age disparities in stage‐specific colon cancer survival across seven countries: An International Cancer Benchmarking PartnershipSURVMARK‐2 population‐based study
Authors: Pilleron Sophie , Charvat Hadrien , Araghi Marzieh , Arnold Melina , Fidler‐Benaoudia Miranda M. , Bardot Aude , Guren Marianne Grønlie , Tervonen Hanna , Little Alana , O'Connell Dianne L. , Gavin Anna , De Prithwish , Aagard Thomsen Linda , Møller Bjørn , Jackson Christopher , Bucher Oliver , Walsh Paul M. , Vernon Sally , Bray Freddie , Soerjomataram Isabelle 
Published: October 2020

AbstractWe sought to understand the role of stage at diagnosis in observed age disparities in colon cancer survival among people aged 50 to 99 years using population‐based cancer registry data from seven high‐income countries: Australia, Canada, Denmark, Ireland, New Zealand, Norway and the United Kingdom. We used colon cancer incidence data for the period 2010 to 2014. We estimated the 3‐year net survival, as well as the 3‐year net survival conditional on surviving at least 6 months and 1 year after diagnosis, by country and stage at diagnosis (categorised as localised, regional or distant) using flexible parametric excess hazard regression models. In all countries, increasing age was associated with lower net survival. For example, 3‐year net survival (95% confidence interval) was 81% (80‐82) for 50 to 64 year olds and 58% (56‐60) for 85 to 99 year olds in Australia, and 74% (73‐74) and 39% (39‐40) in the United Kingdom, respectively. Those with distant stage colon cancer had the largest difference in colon cancer survival between the youngest and the oldest patients. Excess mortality for the oldest patients with localised or regional cancers was observed during the first 6 months after diagnosis. Older patients diagnosed with localised (and in some countries regional) stage colon cancer who survived 6 months after diagnosis experienced the same survival as their younger counterparts. Further studies examining other prognostic clinical factors such as comorbidities and treatment, and socioeconomic factors are warranted to gain further understanding of the age disparities in colon cancer survival.
Brain metabolites in cholinergic and glutamatergic pathways are altered by pancreatic cancer cachexia
Authors: Winnard Paul T. , Bharti Santosh Kumar , Sharma Raj Kumar , Krishnamachary Balaji , Mironchik Yelena , Penet Marie‐France , Goggins Michael G. , Maitra Anirban , Kamel Ihab , Horton Karen M. , Jacobs Michael A. , Bhujwalla Zaver M. 
Published: October 2020

AbstractBackgroundCachexia is a major cause of morbidity in pancreatic ductal adenocarcinoma (PDAC) patients. Our purpose was to understand the impact of PDAC‐induced cachexia on brain metabolism in PDAC xenograft studies, to gain new insights into the causes of cachexia‐induced morbidity. Changes in mouse and human plasma metabolites were characterized to identify underlying causes of brain metabolic changes.MethodsWe quantified metabolites, detected with high‐resolution 1H magnetic resonance spectroscopy, in the brain and plasma of normal mice (n = 10) and mice bearing cachexia (n = 10) or non‐cachexia (n = 9) inducing PDAC xenografts as well as in human plasma obtained from normal individuals (n = 24) and from individuals with benign pancreatic disease (n = 20) and PDAC (n = 20). Statistical significance was defined as a P value ≤0.05.ResultsThe brain metabolic signature of cachexia‐inducing PDAC was characterized by a significant depletion of choline of −27% and −21% as well as increases of glutamine of 13% and 9% and formate of 21% and 14%, relative to normal controls and non‐cachectic tumour‐bearing mice, respectively. Good to moderate correlations with percent weight change were found for choline (r = 0.70), glutamine (r = −0.58), and formate (r = −0.43). Significant choline depletion of −38% and −30%, relative to normal controls and non‐cachectic tumour‐bearing mice, respectively, detected in the plasma of cachectic mice likely contributed to decreased brain choline in cachectic mice. Similarly, relative to normal controls and patients with benign disease, choline levels in human plasma samples of PDAC patients were significantly lower by −12% and −20% respectively. A comparison of plasma metabolites from PDAC patients with and without weight loss identified significant changes in glutamine metabolism.ConclusionsDisturbances in metabolites of the choline/cholinergic and glutamine/glutamate/glutamatergic neurotransmitter pathways may contribute to morbidity. Metabolic normalization may provide strategies to reduce morbidity. The human plasma metabolite changes observed may lead to the development of companion diagnostic markers to detect PDAC and PDAC‐induced cachexia.
Vibrational, spectroscopic, chemical reactivity, molecular docking and in vitro anticancer activity studies against A549 lung cancer cell lines of 5‐Bromo‐indole‐3‐carboxaldehyde
Authors: S. Christopher Jeyaseelan , A. Milton Franklin Benial , K. Kaviyarasu 
Published: October 2020

AbstractSpectroscopic investigations are performed for 5‐Bromo‐1H‐indole‐carboxaldehyde by using experimental (FT‐IR, FT‐Raman) and theoretical (DFT) calculations. Vibrational assignments of the fundamental modes were assigned on the basis of Potential energy distribution (PED) calculations. Electron Localization Function (ELF) and Local Orbital Localizer (LOL) studies were performed to visualize the electron delocalization in the molecule. Frontier molecular orbitals (FMOs) and related molecular properties were computed. The electron‐hole distribution of the molecule was also computed using Multiwfn 3.3.9 software to predict the charge transfer within the molecule. The total and partial density of states (TDOS and PDOS) and also the overlap population density of states (OPDOS) spectra were simulated. UV‐Vis spectrum of the compound was also recorded. The reactive sites of the compound were studied from the MEP and Fukui function analysis. The charge delocalization and stability of the title molecule were investigated using natural bond orbital (NBO) analysis. The lung cancer activity of the title compound against p53 tumor suppressor proteins was studied using molecular docking analysis. The in‐vitro cytotoxic activity of the molecule against human pulmonary lung cancer cell lines (A549) was determined by MTT assay.
Ultrasonic and osmotic pretreatments followed by convective and vacuum drying of papaya slices
Authors: Chandra Abhishek , Kumar Sourabh , Tarafdar Ayon , Nema Prabhat K 
Published: October 2020

AbstractBACKGROUNDPapaya fruit is highly nutritive, but very fragile, and thus has a limited shelf life. Drying is essential to preserve it for longer durations. In this work, osmotic dehydration (OD) with and without ultrasound (US) was applied to papaya slices as a pretreatment in conjugation with vacuum (VD) and convective air drying (AD). Drying was carried out in a novel dryer. Moisture content, drying time, water activity, total color change, total phenolic content, radical scavenging activity, texture, and Fourier‐transform infrared (FTIR) spectrums were evaluated for fresh and dried papaya slices.RESULTSIt was observed that US‐assisted osmotic dehydration (USOD) followed by VD had the lowest drying time with highest retention of phenols and antioxidants as compared to other drying techniques. Higher phenols and antioxidants in US‐pretreated samples were attributed to the release of trapped intra‐cellular polyphenols by cavitation. However, the color characteristics and texture of OD pretreatment followed by convective AD slices were found to be better. Color retention could be due to carotenoid preservation, which would be degraded in other treatments, whereas lower brittleness was associated with lower pectin. Infrared spectroscopy confirmed the retention of phytochemicals and antioxidants in dried papaya slices that were subjected to pretreatment.ConclusionPretreatment before drying enhances the end product quality of dried papaya slices. The results of this study highlight that USOD‐VD is effective for nutrition preservation while OD‐AD is suitable for preserving physical characteristics. © 2020 Society of Chemical Industry
Nitrogen state of Haplic Chernozem of the European part of Southern Russia in the implementation of resource‐saving technologies
Authors: Medvedeva Anna M , Biryukova Olga A , Ilchenko Yaroslav I , Minkina Tatyana M , Kucherenko Alexey V , Bauer Tatiana V , Mandzhieva Saglara S , Mazarji Mahmoud 
Published: October 2020

AbstractBACKGROUNDThe prolonged use of traditional moldboard ploughing often results in soil degradation and, ultimately, has an impact on national food security. Therefore, the implementation of resource‐saving technologies (minimal and No‐till) is a promising approach in the development of agriculture, especially in drought regions. The present study reports the results of long‐term research on the effect of various tillage methods (moldboard ploughing, minimal tillage and No‐till technique) on the nitrogen content of Haplic Chernozem of the European part of Southern Russia. The revealed regularities can be used as a theoretical basis for the effective use of resource‐saving technologies, including No‐till, in the zone of insufficient moisture.RESULTSLong‐term (59 years) cultivation of winter wheat using traditional moldboard ploughing has decreased the soil organic material (SOM) by 35% and total nitrogen by 32% in the soil. Minimization of tillage, in contrast, recovers the nitrogen potential of the soil in winter wheat agrocenoses. There is a statistically confirmed dependence of the content of SOM and total nitrogen on the tillage method of the upper soil horizon, with no significant effect of the tillage methods on intensity ammonification and nitrification. However, the content of nitrate‐nitrogen during resource‐saving tillage methods (22.8–24.4 mg kg−1) was higher than that after ploughing (20.3 mg kg−1) during all the years of the study, indicating the higher content of easily mineralizable nitrogen‐containing compounds in the soil after minimal tillage.CONCLUSIONThe use of resource‐saving tillage technologies under conditions of insufficient moisture stabilizes the nitrogen content in soil and can improve nitrogen nutrition of plants. © 2020 Society of Chemical Industry
Does a coffee plantation host potential pollinators when it is not flowering? Bee distribution in an agricultural landscape with high biological diversity in the BrazilianCampo Rupestre
Authors: Machado Ana Carolina Pereira , Barônio Gudryan Jackson , de Oliveira Favízia Freitas , Garcia Caroline Tito , Rech André Rodrigo 
Published: October 2020

AbstractBACKGROUNDNatural environments within agricultural landscapes have been recognized as reservoirs of biodiversity and, therefore, providers of fundamental ecosystem services to human beings. Bees are the main providers of pollination and thus contribute to the production of food consumed worldwide. In this work, we evaluated the distribution of bees in an agricultural landscape of coffee plantation before and after coffee flowering. We aimed at understanding how richness, abundance and composition of bee communities vary among the different vegetation types within and around the coffee crops.RESULTSA total of 638 bees were collected – 312 in the dry season and 326 in the rainy season – totaling 85 species. The sampling methods collected different species, which provided complementary sampling. OnlyEuglossa leucotrichaandEulaema nigritawere recurrent in both seasons and vegetation types. There was no temporal difference in richness or abundance; however, both varied in relation to the vegetation type and were higher in the coffee‐native transition area. Diverging from richness or abundance, the composition of the communities differed regarding season and vegetation types.CONCLUSIONWe reinforce the importance of maintaining native vegetation in areas surrounding coffee plantations since the crop poorly hosts pollinators when it is not flowering. Natural and semi‐natural areas may act as reservoirs of floral visitors, thus maintaining potential cross‐pollination services available to coffee production. © 2020 Society of Chemical Industry
Determination of bisphenol A: Old problem, recent creative solutions based on novel materials
Authors: Huelsmann Ricardo Dagnoni , Will Camila , Carasek Eduardo 
Published: October 2020

AbstractBisphenol A is a synthetic compound widely used in industry, in the production of polycarbonate, epoxy resins, and thermal paper, among others. Its annual production is estimated at millions of tons per year, demonstrating its importance. Despite its wide application in various everyday products, once in the environment (due to its disposal or leaching), it has high toxicity to humans and animal life, and this problem has been well known for years. Given this problem, many researchers seek alternatives for its monitoring in matrices such as natural water, waste, food, and biological matrices. For this, new advanced materials have been developed, characterized, and applied in creative ways for the preparation of samples for the determination of bisphenol A. This article aims to present some of these important and recent applications, describing the use of molecularly imprinted polymers, metal and covalent organic frameworks, ionic liquids and magnetic ionic liquids, and deep eutectic solvents as creative solutions in sample preparation for the long‐standing problem of bisphenol A determination.
Robust Polariton Bose–Einstein Condensation Laser via a Strong Coupling Microcavity
Authors: Chen Zhiyang , Zheng Huying , Zhu Hai , Tang Ziying , Wang Yaqi , Wei Haiyuan , Su Shichen , Shen Yan , Shan Chongxin 
Published: October 2020

AbstractRobust polariton in the strong‐coupling regime plays a central role in understanding Bose–Einstein condensation (BEC), which is also an ideal platform for the simulation of bosonization processes and novel engineering polariton devices that are related to quantum phase transitions. A two‐dimensional ZnO nanoplate is firstly utilized to construct microcavity polaritons, and a robust polariton BEC laser is successfully realized at room temperature (RT). High stability of the exciton state and the enhanced coupling strength in the nanoplate cavity are effective for polaritons. The giant Rabi splitting of 120 meV is extracted from the RT dispersion pattern. The evolution of polariton BEC exhibits a typical blue‐shift, and its saturation behavior shows that the interaction strength of the polaritons is deduced from the energy renormalization. Remarkably, the value of the interaction strength is two orders of magnitude higher than reported values, which implies that many‐body correlation may be dominant in the polariton strongly interacting polariton systems. The results open up the prospect of realizing robust polariton BEC lasers at high temperature.
Time‐resolved magnetic resonance fingerprinting for radiotherapy motion management
Authors: Li Tian , Cui Di , Hui Edward S. , Cai Jing 
Published: October 2020

PurposeThis study aims to develop a novel time‐resolved magnetic resonance fingerprinting (TR‐MRF) technique for respiratory motion imaging applications.Materials and methodsThe TR‐MRF technique consists of repeated MRF acquisitions using an unbalanced steady‐state free precession sequence with spiral‐in–spiral‐out trajectory. Time‐resolved magnetic resonance fingerprinting was first tested via computer simulation using a four‐dimensional (4D) extended cardiac‐torso (XCAT) phantom for both regular and irregular breathing profiles, and was tested in three healthy volunteers. Parametric TR‐MRF maps at different respiratory phases were subsequently estimated using our TR‐MRF sorting and reconstruction techniques. The resulting TR‐MRF maps were evaluated using a set of metrices related to radiotherapy applications, including absolute difference in motion amplitude, error in the amplitude of diaphragm motion (ADM), tumor volume error (TVE), signal‐to‐noise ratio (SNR), and tumor contrast.ResultsTR‐MRF maps with regular and irregular breathing were successfully generated in XCAT phantom. Numerical simulations showed that the TVE were 1.6 ± 2.7% and 1.3 ± 2.2%, the average absolute differences in tumor motion amplitude were 0.3 ± 0.7 mm and 0.3 ± 0.6 mm, and the ADM were 4.1 ± 0.9% and 3.5 ± 0.9% for irregular and regular breathing, respectively. The SNR of the T1 and T2 maps of the liver and the tumor were generally higher for regular breathing compared to irregular breathing, whereas tumor‐to‐liver contrast is similar between the two breathing patterns. The proposed technique was successfully implemented on the healthy volunteers.ConclusionWe have successfully demonstrated in both digital phantom and healthy subjects a novel TR‐MRF technique capable of imaging respiratory motions with simultaneous quantification of MR multiparametric maps.