bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of flow-controlled ventilation with positive and negative end-expiratory pressure in a swine model of intracranial hypertension
Authors: Schranc Álmos , Daniels John , Südy Roberta , Fontao Fabienne , Bijlenga Philippe , Plourde Guillaume , Quintard Hervé 
Published: December 2024

Abstract
Background
Patients with brain damage often require mechanical ventilation. Although lung-protective ventilation is recommended, the application of increased positive end-expiratory pressure (PEEP) has been associated with elevated intracranial pressure (ICP) due to altered cerebral venous return. This study investigates the effects of flow-controlled ventilation (FCV) using negative end-expiratory pressures (NEEP), on cerebral hemodynamics in a swine model of intracranial hypertension.

Methods
A model of intracranial hypertension involving bilateral trepan bolt holes was performed in 14 pigs. Pressure-controlled volume-guaranteed ventilation (PCV-VG) with PEEP and FCV using PEEP and then NEEP were applied. Intracranial pressure and oxygenation, as well as systemic hemodynamics and gas exchange parameters, were continuously monitored. Data were collected at baseline and at varying PEEP levels for both PCV-VG and FCV ventilation modalities. Following this, FCV ventilation and NEEP levels of -3, -6 and -9 cmH2O were applied.

Results
ICP remained stable with low PEEP levels, but significantly decreased with NEEP. Lower ICP following NEEP improved cerebral perfusion pressure and cerebral tissue oxygenation (p < 0.05 for all). FCV with NEEP at EEP-6 and EEP-9 significantly improved cardiac output and mean arterial pressure (MAP), compared to PCV-VG and FCV using PEEP (p < 0.05, respectively). There were no significant differences in gas exchange parameters between modalities (PCV-VG vs FCV), and between the application of PEEP or NEEP. No significant correlations were observed between ΔICP and ΔMAP.

Conclusion
The application of FCV with NEEP appears to be a safe ventilation mode and offers an additional tool for controlling severe intracranial pressure episodes. These findings warrant validation in future studies and may lead to important potential applications in clinical practice.
Effects of plant oil extracts on the digestibility, hematobiochemistry, and hematology of Clarias gariepinus
Authors: Enyidi U. D. , Asuquo P. 
Published: December 2024

Abstract
Background
Plant oil extract like sesame oil has high polyunsaturated fatty acids, while palm oil extracts are saturated. A serial substitution of crude sesame extract together with crude palm extract was used in novel diets of African catfish. Five types of feeds designated as feed F1 to feed F5 were made to vary in the inclusion of crude sesame extract (CSE) and crude palm extract (CPE), CSE: CPE), as follows: F1, 25:5, F2, 20:10, F3, 15:15, F4, 10:5, and F5, 5:25. Feed F6 was a commercial feed. The fish were fed to satiation for 70 days. We analyzed the digestibility of CSE, CPE, the feeds and the hematology and hematobiochemical parameters of the catfish.

Results
Results showed that the catfish had significantly higher digestibility for CSE 93.34 ± 0.22% than for CPE 78.98 ± 0.11%. Feed F1 had the highest digestibility 91.32 ± 0.07%, followed by feed F2, 82.25 ± 0.04%. The higher digestibility of feeds F1, F2, and F3 than F4 and F5 could be due to the lipids and fatty acid composition of the feed. Sesame seed is known to be high in phospholipids and triacylglycerols, and this enhances digestibility. Phospholipids are present in low quantities in palm oil. Crude sesame extract reduced blood cholesterol, triglycerides, and glucose, while crude palm extract increased them. Conversely higher dietary inclusions of CSE (F1 > F2 > F3) in that order increased the Hb, RBC, MCH, MCHC, TWBC, and the PCV.a

Conclusions
Crude sesame extract should be added to the diets of African catfish for optimal digestibility and enhanced hematobiochemical and hematological indices. Crude palm extract should be added but not above 10% for optimal performances.
Can lung function be used as a predictor of cerebral stroke?
Authors: Elgendy Walid I. M. , Anas Dalia , Nageeb Rania S. , Hassan Hanan A. , Lotfy Samah 
Published: December 2024

Abstract
Background and objectives
Limited research has looked into the precise connection between lung function, arterial blood gases, and cerebral stroke. This study was focused on examining the correlation between pulmonary function and carotid intima-media thickness (CIMT) in patients with and without cerebral stroke who do not have chronic pulmonary disease.

Methods
A case–control study included 125 cerebral stroke patients and 125 non-stroke controls selected from the outpatient clinics of the Neurology and Rheumatology & Rehabilitation departments at Zagazig University Hospital, Sharkia Governorate, Egypt. The assessment of lung function passed through measuring forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), the ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) ratio, and maximum voluntary ventilation (MVV). Arterial blood gases were measured, and CIMT was evaluated using high-resolution ultrasonography by the radiology author.

Results
The research findings suggested that patients exhibiting elevated carotid intima-media thickness (CIMT) faced a heightened risk of suffering from a cerebral stroke in comparison to those with normal CIMT levels. Additionally, the study revealed a negative relationship between lung function, as measured by FEV1, FVC, the ratio (FEV1/FVC), and MVV, and arterial blood gases, as indicated by the partial pressure of oxygen (PaO2), in relation to CIMT. Reduced FEV1, FVC, FEV1/FVC, MVV, and PaO2 were found to be associated with elevated CIMT. The stepwise multivariable regression model further showed that CIMT was positively correlated with age, while it displayed negative correlations with FEV1, FVC, FEV1/FVC, MVV, and PaO2.

Conclusion
Patients who have an elevated carotid intima-media thickness (CIMT) are at a greater risk of experiencing a cerebral stroke. In addition, reduced forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, maximal voluntary ventilation (MVV), and arterial partial pressure of oxygen (PaO2) are all linked with increased CIMT levels. Patients with elevated CIMT have a higher risk of cerebral stroke. These findings suggest that lung function tests in individuals without respiratory conditions could be beneficial for identifying those who may be at a heightened risk for experiencing a cerebrovascular stroke.
Evidence for music therapy and music medicine in psychiatry: transdiagnostic meta-review of meta-analyses
Authors: Lassner Alexander , Siafis Spyridon , Wiese Emanuel , Leucht Stefan , Metzner Susanne , Wagner Elias , Hasan Alkomiet 
Published: December 2024

Background
Music therapy is a commonly used intervention added to usual care for psychiatric disorders.

Aims
We review the evidence for music therapy and assess its efficacy as an adjunct therapy across psychiatric disorders.

Method
A systematic literature search was conducted in four scientific databases to identify relevant meta-analyses. Articles were assessed with the AMSTAR-2 tool. The results of the high-quality articles were recalculated with the data from the primary studies. We decided to add the results of the lower-rated articles, using a narrative approach. We pooled the primary studies and calculated standardised mean differences (SMD) for the transdiagnostic outcomes of depression, anxiety and quality of life. We used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool to assess the level of evidence.

Results
Meta-analyses were available for autism, dementia, depression, insomnia, schizophrenia and substance use disorders. We identified 40 relevant articles. One article per domain was identified as high quality. Music therapy added to treatment as usual showed therapeutic value in each disorder. The transdiagnostic results showed a positive effect of music therapy on depression (SMD = 0.57, 95% CI 0.36–0.78), anxiety (SMD = 0.47, 95% CI 0.27–0.66) and quality of life (SMD = 0.47, 95% CI 0.24–0.71). However, these effects were not maintained at follow-up, and all results were based on low or very low evidence.

Conclusions
Music therapy shows promising potential as an adjunctive treatment for psychiatric disorders, but methodological weaknesses and variability limit the evidence. More high-quality, well-powered studies are needed to reliably confirm its effect size.
Selpercatinib Treatment Beyond Progression in
RET
Fusion–Positive Non–Small Cell Lung Cancer
Authors: Besse Benjamin , de Miguel Maria , Kim Yu Jung , Johnson Melissa L. , Chan Jason , Peterson Patrick , Szymczak Sylwia , Puri Tarun , Oxnard Geoffrey R. , Tan Daniel S.W. 
Published: December 2024

PURPOSE

Selpercatinib, a highly selective
RET
kinase inhibitor with CNS activity, is approved in multiple countries for patients with
RET
fusion–positive non–small cell lung cancer (NSCLC).

METHODS

Patients with NSCLC were treated on the phase I/II LIBRETTO-001 trial (ClinicalTrials.gov identifier:
NCT03157128
) and were permitted to continue selpercatinib beyond investigator-assessed progressive disease (PD) if the patient derived ongoing benefit according to the investigator and with sponsor approval. Data from patients with PD confirmed by an independent review committee were used for this analysis (N = 80 of 356 patients with NSCLC enrolled; data cutoff date of January 13, 2023).

RESULTS
Eighty patients had radiologically confirmed PD and continued selpercatinib per investigator assessment. Median duration of treatment beyond PD was 5.9 months. Of the 80 patients, 57 had oligoprogression (oligoPD), including 20 with 1-2 progressing lesions and 37 with 3-5 progressing lesions, whereas 23 had widespread progression (more than five progressing lesions). Median time on treatment beyond PD for patients with oligoPD was 9.8 months. Postprogression median time on treatment (ToT) appeared comparable between patients who progressed in CNS only (n = 8; 7.5 months) versus patients with extracranial PD (n = 68; 6.4 months). Of the 80 patients receiving postprogression therapy, 33 (41.3%) received local radiotherapy upon disease progression. Concurrent radiotherapy extended the ToT for patients across all subpopulations.

CONCLUSION
Continuing selpercatinib beyond progression is feasible and may be considered, particularly for patients with limited oligoPD, including patients with CNS progression.
Performance prediction of a two-port terahertz-based graphene–silicon-based tunable antenna with polarization and pattern diversity features using machine-learning algorithms
Authors: Tripathi Satyendra , Sundaram  , Chadhar Ram Milan , Ranjan Ravi , Tripathi Devendra Kumar 
Published: December 2024

This paper proposes a hybrid twin-port radiator with polarization and pattern diversity features in the terahertz (THz) frequency domain. Three major contributions of the proposed antenna design are: (i) a rounded wave is obtained by stimulating the silicon ceramic via a fan blade formed slot; (ii) a mirror orientation of aperture and suspension of partially reflecting surface (PRS) helps to get better isolation with an S-component and far-field component, respectively; and (iii) the random forest and XGBoost technique predicts the |S11| of the designed aerial effectively. A coating of graphene over silicon dielectric makes the radiator tunable. The optimized outcome confirms that the planned aerial operates effectively in between 2.45 and 3.15 THz with less than 3-dB axial ratio from 2.61 to 2.89 THz. PRS tilts the beam gotten from port-1 and port-2 by ±30∘. The design is suitable for THz-based cellular machines because of all these qualities.
Characterizing changes in executive functions and performance in daily activities after chemotherapy: A pre-post mixed-methods study protocol
Authors: Loubani Khawla , Rand Debbie , Agbarya Abed 
Published: December 2024

Background
Impairments in higher cognitive abilities (termed executive functions (EF) are common among individuals with cancer following chemotherapy and may impact their performance of daily activities. Our aim is to better understand the changes in EF and the impact on performance in daily activities of individuals with cancer pre- and post-chemotherapy.

Methods
A convergent parallel mixed-method pre-post experimental design. Qualitative and quantitative data will be collected pre- and post-chemotherapy (12 weeks following chemotherapy commencement). Participants will be adult candidates for chemotherapy who are newly diagnosed with non-central nervous system malignancy, stages I–III. The Canadian Occupational Performance Measure will assess the performance of daily activities; secondary measures include EF, cognitive functioning, fatigue, and emotional well-being. Qualitative data will be collected via open-ended questions. Pre- and post-chemotherapy, quantitative and qualitative data will be analyzed separately and merged into an overall interpretation. It is expected that, pre-chemotherapy, no difficulties in performing daily activities will be revealed. Post-chemotherapy EF impairments will be apparent and their impact on the performance of daily activities will be identified.

Conclusions
Integrating quantitative and qualitative measures will contribute to a comprehensive understanding of the individuals’ cognitive needs and may enable the development of effective interventions to minimize deterioration in daily activities after chemotherapy.
A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples
Authors: Mah Jasmine C. , Theou Olga , Perez-Zepeda Mario Ulises , Penwarden Jodie L. , Godin Judith , Rockwood Kenneth , Andrew Melissa K. 
Published: December 2024

Background
The construct of social vulnerability attempts to understand social circumstances not merely as a descriptor, but as a predictor of adverse health events. It can be measured by aggregating social deficits in a social vulnerability index (SVI). We describe a standard procedure for constructing a multi-level SVI using two working examples.

Methods
First, we describe a six-step approach to constructing a SVI. Then, we conducted a secondary analysis of a clinical dataset (Canadian Immunization Research Network’s Serious Outcomes Surveillance Network (SOS)) and a population-based dataset (Canadian Longitudinal Study on Aging (CLSA)). In both datasets, we construct SVIs, use descriptive statistics to report distributions by age and sex, and perform a multivariable linear regression of social vulnerability on frailty.

Results
Procedures for drafting a list of candidate social items, selecting deficits for inclusion, and screening deficits to meet inclusion criteria were applied to yield a 18-deficit SVI for the SOS and 74-deficit SVI for the CLSA. Deficits in each SVI were re-scored between 0 and 1, where 1 indicates the greater risk. Finally, the sum of all deficits is calculated into an index. In the SOS, SVI was associated with age only for females and was weakly associated with frailty (r = 0.26, p<0.001). In the CLSA, SVI was associated with age for both sexes and moderately associated with frailty (r = 0.41, p<0.001).

Conclusion
We present a standard method of constructing a SVI by incorporating factors from multiple social domains and levels in a social-ecological model. This SVI can be used to improve our understanding of social vulnerability and its impacts on the health of communities and individuals.
Sickness absence and disability pension trajectories among individuals on sickness absence due to stress-related disorders. Two prospective population-based cohorts with 13-month follow-up
Authors: Gémes Katalin , Pettersson Emma , Sjölund Andoff Sara , Farrants Kristin , Friberg Emilie , Alexanderson Kristina 
Published: December 2024

Background
Stress-related disorders are common diagnoses for sickness absence (SA) and disability pension (DP) in many Western countries. Knowledge on future SA/DP trajectories among those starting such a SA spell is limited. The aims were to identify future SA/DP days trajectories among individuals starting an SA spell due to stress-related disorder and investigate socio-demographic and morbidity characteristics associated with specific trajectories.

Methods
Using microdata from nationwide registers, we established two cohorts of all living in Sweden who started a new SA spell >14 days due to stress-related disorder in 2011 (N = 32,417) or in 2018 (N = 65,511), respectively. Group-based trajectory models were used to identify trajectories of monthly average SA/DP days during the following 13 months, separate for each cohort. We used multinomial logistic regression to investigate the associations between sociodemographic and morbidity-related predictors and trajectory membership.

Results
We identified six SA/DP trajectories in the two cohorts: steep drop (30.6% and 35.9% of all included in 2018 and 2011); constant fluctuating (8.7%, 11.2%); fast decrease (25.5%, 24.4%); medium decrease (18.1%, 13.1%); slow decrease (10.8%, 7.3%), and constant high (6.2%, 8.0%). The distributions of sociodemographic factors, multi-morbidity, and history of SA/DP differed between the trajectory groups. For example, compared to the steep drop trajectory, individuals in the other trajectories were more likely to be a woman, older, having had prior SA/DP or specialized outpatient healthcare visits.

Conclusions
In these two explorative, population-wide cohorts, we identified six different trajectories of SA/DP days among all with a new SA spell with stress-related disorders. The trajectory groups differed regarding both sociodemographic and health-related covariates.
Escrita de si e amizade no filme “Gabriel e a Montanha”, de Fellipe Barbosa
Authors: Da Silva Daniela 
Published: December 2024

Resumo: O texto trata das noções de “amizade” e de “escrita de si”, a partir do filme Gabriel e a Montanha, de Fellipe Barbosa. A discussão inscreve-se nos estudos de Michel Foucault, acerca de uma “estética da existência”, articulando o cinema e as práticas ascéticas, como exercícios de autotransformação e aprendizagem de si. Para tanto, utiliza-se o método de pesquisa, nomeado de “memórias de formação”; voltado a discutir as narrativas de pessoas, em relação as suas experiências de criação com as linguagens poéticas. Desse modo, é possível aproximar processos artísticos e modos de existência, no interior de um debate ético e estético, acerca das relações entre arte, vida e formação.
Palavras-chave: Amizade; Cinema; Formação; Escrita de Si; Estética da Existência.
Self-writing and friendship in the film “Gabriel and the Mountain”, by Fellipe Barbosa
Abstract: The text deals with the notions of "friendship" and "self-writing", from the film Gabriel and the Mountain, by Fellipe Barbosa. The discussion is part of the studies of Michel Foucault, about an “aesthetics of existence”, connecting cinema and ascetic practices, as exercises of self-transformation and self-learning. Therefore, the research method, called “memories of formation” is used; aimed at discussing people’s narratives, in relation to their experiences of contact and creation with poetic languages. Thus, it is possible approaches artistic processes and modes of existence, within an ethical and aesthetic debate, about the relationships between art, life and formation.
Keywords: Friendship; Cinema; Formation; Self-Writing; Aesthetics of Existence.
Escrita de sí y amistad en la película “Gabriel y la Montaña”, de Fellipe Barbosa
Resumen: El texto trata de nociones de “amistad” y de “escrita de sí”, a partir de la película Gabriel y la montaña, de Fellipe Barbosa. La discusión se inscribe en los estudios de Michel Foucault, acerca de una “estética de la existencia”, articulando el cine y las prácticas escépticas, como ejercícios de autotransformación y aprendizaje de sí. Para ello se utiliza el método de investigación, denominado “memorias de formación”; destinado a discutir las narrativas de las personas, en relación con sus experiencias de contacto y creación con lenguajes poéticos. Así, es possible aproximar procesos artísticos y modos de existencia, en el interior de un debate ético y estético, sobre las relaciones entre arte, vida y formación.
Palabras clave: Amistad; Cine; Formación; Escrita de Sí ; Estética de la Existencia.
1 Este trabalho faz parte de uma pesquisa maior advinda da tese: Memórias de formação: Inventar com vozes artistas uma escrita em educação. Ver: Silva, 2024.
Data de registro: 11/07/2024
Data de aceite: 27/11/2024
Mal radical e vícios diabólicos em Kant
Authors: Correia Adriano 
Published: December 2024

Kant insiste que não é possível uma corrupção radical da razão moral legisladora. Mesmo os piores malfeitores jamais extirpam de si o respeito pela lei moral. O mal moral é antes de tudo concebido como fragilidade, autoengano, desejo de felicidade. Não obstante, Kant considera a possibilidade de abrigarmos vícios diabólicos, principalmente em seus textos da década de 1890, sobre os quais mais nos determos nesse texto. Mesmo não admitindo uma vontade diabólica, que queira o mal pelo mal, Kant assume que podemos ter vícios diabólicos, como a alegria com o mal alheio, mobilizados por paixões e afetos. O objetivo desse texto é fazer uma exploração preliminar dessa articulação complexa entre um mal autointeressado traduzido na doutrina do mal radical e vícios diabólicos que apontam para males que ultrapassam a humanidade.
Palavras-chave: Mal Radical; Vícios Diabólicos; Immanuel Kant.
Radical evil and diabolical vices in Kant
Abstract: Kant asserts that a radical corruption of legislative moral reason is not possible. Even the worst evildoers never eradicate respect for the moral law from themselves. Moral evil is understood primarily as weakness, self-deception, and desire for happiness. Nevertheless, Kant considers the possibility that we harbor diabolical vices, particularly in his texts from the 1890s, which we will focus on in this text. Even if he does not admit a diabolical will that wants evil for its own sake, Kant assumes that we can have diabolical vices, such as joy at the suffering of others, which are mobilized by passions and affections. The purpose of this paper is to make a preliminary exploration of this complex articulation between a self-interested evil manifested in the doctrine of radical evil and diabolical vices, which point to evils beyond humanity.
Keywords: Radical Evil; Diabolical Vices; Immanuel Kant.
Mal radical y vicios diabólicos en Kant
Resumen: Kant insiste que no es posible una corrupción radical de la razón moral legisladora. Incluso los peores malhechores jamás erradican de ellos el respeto por la ley moral. El mal moral es antes de todo diseñado como fragilidad, autoengaño y deseo de felicidad. Sin embargo, Kant considera la posibilidad de albergarse vicios diabólicos, principalmente en sus textos de la década de 1890, sobre los cuales más nos centraremos en este texto. Aunque no admite una voluntad diabólica, que quiera el mal por el mal, Kant asume que podemos tener vicios diabólicos, como la alegría por el mal ajeno, movilizados por las pasiones y afectos. El objetivo de este texto es hacer una exploración preliminar de esa articulación compleja entre un mal auto interesado traducido en la doctrina del mal radical y los vicios diabólicos que apuntan para males que ultrapasan la humanidad.
Palabras-clave: Mal Radical; Vicios Diabólicos; Immanuel Kant.
Data de registro: 22/07/2024
Data de aceite: 28/08/2024