bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Bailout and Planned Rotational Atherectomy for Severe Coronary Calcified Lesions
Authors: CAO Cheng-fu , MA Yu-liang , LI Qi , LIU Jian , ZHAO Hong , LU Ming-yu , wang weimin 
Published: March 2020

Abstract
Objective : To compare outcomes of bailout and planned rotational atherectomy (RA) in the treatment of severe calcified coronary lesions.
Methods: Data of patients treated with RA from 2017 to 2018 at a single-center registry were retrospectively analyzed. All patients were divided into planned RA and bailout RA groups, data between two groups were compared.
Results: A total of 190 patients were included in this study, 138 patients received planned RA and 52 patients received bailout RA. Baseline clinical characteristics had no significant differences between groups. The number of implanted stents and total stents length were similar. But the number of balloon (1.6±0.8 vs. 2.7±1.3, P <0.001), operation time (83.5±26.2 vs. 100.8±36.4min, P =0.007), fluoroscopy volume (941±482 vs. 1227±872mGy, P =0.012] and contrast amount （237±62 vs. 275±90ml, P =0.003）were all lower in planned RA group. Planned RA had a higher procedural success rate (99.3% vs. 92.3%, P =0.007) and a lower complication incidence (4.3% vs. 17.3%, P =0.009). But the cumulative 3-year incidences of MACE events (9.2% and 16.6%, log rank p 0.24) had no difference between groups.
Conclusion: For severe coronary artery calcification, although planned RA did not reduce MACE compared with bailout RA, but it can improve the immediate procedural success rate, reduce the incidence of complications, the operation time and the volume of contrast.
Keywords: severe coronary calcified lesions, planned rotational atherectomy, bailout rotational atherectomy
Opsonization of Early Apoptotic Cells by IgG from Lupus Nephritis Amplifies Activation of Early Complement Components and Promotes Inflammatory Phagocytosis
Authors: Wang Chenghua , Zhao Bing , Liu Xiang , Yang Xiaowei 
Published: March 2020

Abstract
Background

SSA/Ro 60 has been reported to be exposed on the surface of early apoptotic cells and recognized by autoantibodies from lupus. The aim of this study was to explore the subsequent effects of the binding of IgG from anti-SSA positive LN patients on the fate of early apoptotic cells.

Results

IgG which have been confirmed with extensive binding to early apoptotic cells were purified from three anti-SSA positive LN patients. Opsonization of early apoptotic cells by IgG from LN augmented C3c deposition without influence on the assembly of the terminal complement components or cell lysis. IgG from LN enhanced opsonization and phagocytosis of early apoptotic cells by macrophages directly or dependent on complement activation, with massive TNF-a and IL-1β secretions.

Conclusions

IgG from anti-SSA positive LN facilitates early apoptotic cell clearance by macrophages and triggers proinflammatory cytokines release, possibly exacerbating underlying pathogenic mechanisms in lupus nephritis.
Formulation of a Multifunctional Plant Additive Based on the Interaction of its Components
Authors: Bobreneva Irina , Baioumy Ahmed Adel , Tokarev Alexey 
Published: March 2020

Introduction. The research featured the physicochemical and functional properties of tiger nut (Cyperus esculentus), quinoa (Chenopodium quinoa), and their mixes. The research objective was to study the effects of their interfacial interaction and the qualitative characteristics of meat model systems, as well as general opportunities for their use in meat products.
Study objects and methods. The tiger nut is a traditional plant that grows in Egypt. It is often used in beverages and bakery. The quinoa is a cereal product that grows mainly in Peru and Colombia. A set of experiments was conducted to determine such colloidalchemical parameters as optical density, electrical conductivity, solubility, pH, and effective viscosity. The studied additives proved to be synergists. The research also included the organoleptic characteristics of meat model samples prepared with a mix of tiger nut and quinoa at different ratios as a partial replacement of raw meat. The mix substituted 5% of the meat system. Tiger nut and quinoa used as a substitute for raw meat positively affected such indicators of the finished product as taste, smell, color, and aroma. The obtained data were analyzed with the help of a specialized software package “Multimeat Expert”. The optimal ratio of tiger nut and quinoa in the mix was determined as 1:1.
Results and discussion. The mix of tiger nut and quinoa “TiQi” contained 11.38% of dietary fiber, 14.35% of lipids, and 9.37% of protein. In addition, the mix contained a large amount of minerals: potassium – 636.61 mg/100 g, calcium – 68.54 mg/100 g, and vitamins C, E, and B. Its antioxidant activity reached 20.41 mg/g.
Conclusion. The obtained mix of tiger nut and quinoa could be used as a functional ingredient in meat products to increase the content of dietary fibers, as well as vitamins and minerals. In addition, “TiQi” demonstrated good antioxidant activity and increased the shelf life of meat products.
Leczenie napromienianiem raka stercza na podstawie doniesień z Konferencji Amerykańskiego Towarzystwa Radioterapii Onkologicznej (ASTRO), San Francisco 2014 oraz Europejskiego Towarzystwa Radioterapii Onkologicznej (ESTRO ), Turyn 2015
Authors: Milecki Piotr 
Published: March 2020

Rak stercza należy do najczęściej diagnozowanych nowotworów złośliwych u mężczyzn w krajach rozwinietych. Z tego też powodu optymalne leczenie chorych z tym nowotworem jest szczególnym wyzwaniem dla lekarzy onkologów radioterapeutów, urologów i onkologów klinicznych. W związku z tym podczas konferencji naukowych ASTRO i ESTRO dużo uwagi poświęcono właśnie temu nowotworowi. Ostatnio przeprowadzone badania kliniczne wskazują, że zastosowanie terapii hormonalnej w skojarzeniu z nowoczesnym napromienianiem, poza bardzo pożądanym efektem jakim jest poprawa przeżyć chorych w grupie chorych o pośrednim i wysokim ryzyku progresji, może przyczynić się do zmniejszenia powikłań popromiennych. W trakcie konferencji przedstawiono takže wyniki badań klinicznych, które potwierdzają zysk w wyniku zastosowania eskalacji dawki w radioterapii. Niemniej zysk w efekcie kontroli biochemicznej wymaga długiego czasu przeżycia chorych aby przełożył się na zysk w przeżyciach całkowitych lub swoistych dla raka stercza.
Flow Modeling of Mithi River in Mumbai Catchment
Authors: Sharma M. , Gupta K. 
Published: March 2020

Mumbai receives an average annual rainfall of 2100 mm; all of it during the monsoon months from June to September. Mumbai originally consisted of seven individual islands which have been merged through landfill over the past 300 years. The city population has grown to 16.36 million (2001 census) but the city infrastructure has not kept pace with the rate of population growth. Although the water supply has increased, it has been difficult to provide new drainage facilities. This has resulted in local system overloads and causes severe flooding on an average twice a year. This happen when high intensity rainfall (&gt;50 mm/hr) occurs continuously for 2-3 hours coinciding with the occurrence of high tides.
Mithi River catchment is the largest catchment in Mumbai. The main objective of this study is to quantify the volume of flows at key points in the Mithi River system and to evaluate alternatives to reduce flooding in the catchment using the Australian urban drainage modeling software DRAINS. The option of detention basin at suitable locations to control flooding in the catchment has been simulated and it is concluded that the provision of detention basin can reduce flooding by 50 to 95% at various points in the catchment.
Strategies for Condition Assessment of Sewer Systems
Authors: Müller K. 
Published: March 2020

The inspection of sewers can take place whether by means of fixed-intervals in a conventional surface-covering inspection, or by means of need-oriented strategies. Those need-oriented strategies can be differed between a selective inspection, an evaluation of the present sewer condition based on a representative samples and a failure-oriented forecasting strategy.
By setting up and implementing a numerical model it is now possible to carry out a comparison between strategies. Herewith, the potential of success from every single strategy concerning different boundary conditions has been evaluated.
For larger Sewer Systems a failure-oriented forecasting strategy presents a more reasonable alternative than the conventional surface-covering one. The reason is because the holding time from every sewer in a critical condition can be reduced considerably within this kind of oriented-need inspections compared to the conventional ones. Similarly, this method meets the ability to estimate the whole condition of a sewer for a given term in the minimum time, which usually could not be achieved by a conventional inspection. Oriented-need inspection strategies offer even superior advantages when the crop and the ground water pollution regulation controls have been followed from the beginning, in order to reduce holding times within sewers in a critical class-condition.
Scenarios for redesigning an urban drainage system to reduce runoff frequency and restore stream ecological condition
Authors: Ladson A. R. , Lloyd S. , Walsh C. J. , Fletcher T. D. , Horton P. 
Published: March 2020

Monitoring the hydrochemical efficiency of urban stormwater treatment devices is not straightforward as the traditional, automated, In urban areas, efficient drainage of impervious surfaces means that polluted stormwater is frequently delivered to streams. Commonly, catchment urbanization can increase runoff frequency by a factor of 10 or more, as the effective imperviousness - the proportion of the catchment that consists of impervious surfaces drained to streams - is increased. This causes a decline in stream health.
To decrease runoff frequency, effective imperviousness must be reduced. This requires urban drainage systems to be redesigned, using techniques such as infiltration and rainwater harvesting, so that stormwater from small rain events is not piped directly to streams but instead is infiltrated, reused or retained. We have developed scenarios that explore alternative urban drainage systems appropriate for a small partly urbanised catchment in Melbourne’s east. These scenarios incorporate, biofiltration basins, swales and dual purpose rainwater tanks that supply water for householders. Our results suggested that sufficient reductions in effective imperviousness and runoff frequency are possible to achieve improvements in stream health.
The first two years of full scale operation of the two-stage Main Wastewater Treatment Plant of Vienna
Authors: Wandl G. , Schaar H. , Papp M. , Svardal K. 
Published: March 2020

The Main Wastewater Treatment Plant of Vienna had to be extended to guarantee sufficient nitrogen removal. After intensive evaluation studies a two-stage activated sludge system was chosen for the plant-extension. Due to the very small specific reactor tank volume of two-stage treatment plants in comparison with low loaded single-stage plants internal cycles had to be applied to ensure sufficient nitrogen removal.
Starting in the year 2000 the plant extension was finished by the beginning of 2005 and the extended plant went into operation in spring. The Austrian effluent standards had to be fulfilled by December 2005.
This paper presents a description of the plant layout and gives an overview of the operating results of the first two years of full scale operation. Mass balances were used to evaluate the pathways of nitrogen removal. The results confirmed the expected flexibility of the chosen concept; nitrogen elimination did not decrease although the effluent recirculation that has been implemented to ensure sufficient nitrogen removal efficiency especially during winter had been reduced markedly due to energy reasons. The treatment efficiency that was observed at pilot plant investigations was clearly exceeded.
Detoxification of Waste Water Contaminated with Imidacloprid using Homogeneous and Heterogeneous Photo-Fenton Processes
Authors: Zaror C.A. , Segura C. , Mansilla H. , Mondaca M. A. , González P. 
Published: March 2020

This paper presents experimental results on the removal of Imidacloprid from waste water using homogeneous and heterogeneous photo-Fenton processes. Experiments were conducted in a 2 L photo reactor, initial concentrations in the range 10 - 40 mg L-1 Fe(II) and 100 - 450 mg L-1 H2O2; 30 - 150 min processing times.
Initial H2O2 concentration determined the extent of the oxidation process, whereas iron concentration played a key role in the process kinetics. Homogeneous photo-Fenton showed a fast initial reaction leading to 50% Imidacloprid degradation after less than 1 min treatment, followed by a slower process until full removal was achieved. Rapid Fe(II) oxidation to Fe(III) seems responsible for the initial Imidacloprid removal. TOC and COD removal up to 77% and 88%, respectively, were measured. Heterogeneous photo Fenton, using co-acrylic acid polyacrylamide resin as a solid support, presented similar trends than homogeneous applications, although the overall process proceeded at a slower rate.
Untreated Imidacloprid samples showed significant acute toxicity to Daphnia magna and genotoxic effects on Bacillus subtilis. Acute toxicity and genotoxicity remained detectable even after complete pesticide removal, showing that toxic by-products were present.
Use of bank filtration systems in the sub-tropical region of the lower Brahmaputra valley
Authors: Ronghang Medalson , Barman Pranjal , Medhi Hemantajeet , Brahma Kamal Kumar , Misra Arup Kumar 
Published: March 2020

Abstract
River bank filtration (RBF) is a natural method of obtaining surface water from a river or lake via the sub-surface for domestic use. It has been intensively used worldwide to augment water supply systems for sustainability and can be operated under various conditions. Its energy requirements are comparatively lower than those of conventional water treatment systems.
Field investigations were carried out at various locations in Kokrajhar district of Assam, India to assess groundwater quality and aquifer characteristics. The results suggest that major water quality parameters were within the Indian drinking water standards. The iron concentration exceeded the permissible maximum in more than 50% of samples from hand pumps, its concentration ranging between 0.33 and 3.50 mg/L. The pH was mostly in the range 5.4 to 7.4, suggesting that the water is slightly acidic. Aquifer and riverbed material collected along the banks of the Gaurang River were sieved, and classified as coarse silt to fine gravel, with gravel and sand predominant. The hydraulic conductivity, determined from the grain size distributions, were between 5 × 10−3 and 1.4 × 10−2 m/s, suggesting good aquifer permeability. The maximum safe well yield was estimated at 2,000 to 7,500 L/min, and the mean travel time at less than a week during the monsoon and more than 3 years under non-monsoon conditions.
The aim of this paper is to demonstrate the RBF method for treating river water naturally under wet climatic conditions. The lower Brahmaputra basin is a unique physiographic setting with a powerful monsoon regime and a fragile geological base. The approach was to prepare a comparative study of water quality and aquifer characteristics with the present site and few active RBF sites.
Drug Discovery of Acetophenone Derivatives as BRD4 Inhibitors
Authors: Zhang Zhimin , Huang Wenhai , Zheng Xiaoliang , Li Chuansheng , Shen Zhengrong 
Published: March 2020

Background:
The bromodomain and extra-terminal proteins (BET), in particular BRD4,
has recently emerged as a potential therapeutic target for the treatment of many human disorders
such as cancer, inflammation, obesity and cardiovascular disease, which draw more and more
attention to discover potent BRD4 inhibitors in the past years. In this article, we described the
discovery process of an entirely new chemotype of BRD4 inhibitors.

Methods:
A fragment-based drug discovery strategy was employed in attempting to find a novel
chemotype of BRD4 inhibitors. Thus, the potential hits were firstly identified by docking study with
KAc binding pocket and AlphaScreen assay. Then the elected hit was further structurally optimized
based on the interaction revealed by the docking study and the Structure-Activity Relationship
(SAR).

Results:
A 1-(2-hydroxyphenyl)ethan-1-one fragment was first identified as an efficient hit to BRD4
with a weak inhibition activity and high ligand efficiency (IC50 = 8.9 μM, LE > 0.5) based on
virtual screening and biochemical assay. Then, two-rounds optimization of the hit by a fragmentbased
drug discovery approach enabled the discovery of a potent BRD4 inhibitor 9, which exhibit
nanomolar potency in biochemical assays (IC50 = 0.18 μM).

Conclusion:
The title compounds displayed potent inhibitory activity to BRD4, implying
acetophenone core is an effective KAc residue mimic, suggesting acetophenone derivatives as a new
chemotype may be promising for developing novel BRD4 inhibitors.
Development and Validation of a Stability-indicating HPLC Method for the Analysis of Cabazitaxel in Jevtana® Concentrate-solvent Leftover Samples
Authors: Arnamo Hedvig , Hillebrand Michel J.X. , Huitema Alwin D.R. , Nuijen Bastiaan , Rosing Hilde , Beijnen Jos H. 
Published: March 2020

Aim/Background:
In this study, a stability-indicating method of the anticancer agent cabazitaxel was developed and validated. This method will be used to determine the chemical stability of commercially available concentrate-solvent mixture cabazitaxel (Jevtana®) to examine the possibility of multi-dosing from the same product vial after storage. The impossibility to re-use leftovers today is contributing to an unnecessary and significant financial waste.

Methods:
A forced degradation study of cabazitaxel was performed under different conditions to produce degradation products. Acidic, basic, oxidation, heat, and ultraviolet (UV) light conditions were tested. The method to determine the stability was developed so that potential degradation products would be shown in the UV spectra after separation from cabazitaxel with a C18 column in a high-performance liquid chromatography (HPLC) system. The only degradation product occurring during storage in room temperature and ambient light was identified by accurate mass Orbitrap Mass Spectrometry.

Results:
A stability-indicating method for cabazitaxel (Jevtana®) concentrate-solvent mixture has been
developed. We demonstrated that this method can be applied to stability studies with the purpose of
multi-dosing cabazitaxel from a chemical/physical stability perspective within the tested period of time
and conditions.

Conclusion:
As an addition, the only naturally occurring degradation product found has been identified
and a degradation reaction has been suggested.
Cereal-based Complementary Foods Marketed in the City of Yaounde: Assessment of the Compliance to Labeling and Nutritional Composition Standards
Authors: Rolly Mvogo N. , Michelle Djouhou F. , Brice Saha F. , Blaise Kuagny M. , Borelle Mafogang , Elie Fokou 
Published: March 2020

Background:
Complementary foods are foods intended for consumption by infants and young children to supplement then replace their milk diet. Compliance with labeling and nutritional composition standards conditions their nutritional quality.

Objective:
The aim of this study was to assess the compliance level of Cereal-based Complementary Foods (CCFs) marketed in the city of Yaounde to related standards.

Methods:
A descriptive cross-sectional study was conducted among 125 mothers in 2 hospitals of Yaounde using probabilistic cluster sampling. The labelings and nutritional compositions of the most consumed CCFs coded as “ASC O”, “ASC I”, “ASC E” and “ASC A”, were compared to Codex Alimentarius standards at an acceptability threshold of 80%.

Results:
The labeling standards were 95.24%, 93.48%, 89.68% and 59.34% compliant for “ASC O”, “ASC I”, “ASC E” and “ASC A” respectively, 52.5%, 73.75%, 83. 75% and 35% for nutritional composition standards. 90% of these CCFs complied with labeling standards, while only 26% with nutritional composition standards.

Conclusion:
CCFs in Yaounde have as main defects: incomplete labels, labels with errors and falsities, protein and mineral deficiencies. Their producers, controllers, and buyers should respectively improve, control and seek their good quality for the well-being and good health of infants and young children.
Consumers’ Perceptions on Plastic Bags Tax Levy in Peri-urban Areas of Eswatini: A Case of Kwaluseni and Logoba Chiefdoms
Authors: Mavuso M. M. , Singwane S. S. 
Published: March 2020

Introduction:This study focused on assessing the perceptions of consumers on plastic bags tax levy in peri-urban areas of Eswatini, using Kwaluseni and Logoba chiefdoms as case studies.Methods:The areas of key focus include knowledge of and attitudes of consumers towards plastic bags pollution, strategies employed by consumers to manage plastic bags, consumers’ willingness to pay for plastic bags and what Eswatini Environment Authority has done so far in controlling plastic bags pollution.Results:A total of 165 households, (99 from Kwaluseni and 66 from Logoba) were conveniently sampled and interviewed with the aid of a questionnaire. Community leaders and an environmental inspector from Eswatini Environment Authority were also interviewed. The findings show that the use of plastic bags is increasing in both chiefdoms (92.93% at Kwaluseni and 92.42% at Logoba). Concerning what respondents do with the plastics bags after ferrying their goods home, 25% at Kwaluseni and 19% at Logoba of the respondents claimed to reuse some bags and throw away the rest.Conclusion:With regard to willingness to pay, the findings indicate that 49.70% of the respondents are willing to buy plastic bags.
Using Generalized Linear Mixed Models to Predict the Number of Roadway Accidents: A Case Study in Hamilton County, Tennessee
Authors: Laflamme Eric M. , Way Peter , Roland Jeremiah , Sartipi Mina 
Published: March 2020

Introduction:
A method for identifying significant predictors of roadway accident counts has been presented. This process is applied to real-world accident data collected from roadways in Hamilton County, TN.

Methods:
In preprocessing, an aggregation procedure based on segmenting roadways into fixed lengths has been introduced, and then accident counts within each segment have been observed according to predefined weather conditions. Based on the physical roadway characteristics associated with each individual accident record, a collection of roadway features is assigned to each segment. A mixed-effects Negative Binomial regression form is assumed to approximate the relationship between accident counts and several explanatory variables including roadway characteristics, weather conditions, and several interactions between them. Standard diagnostics and a validation procedure show that our model form is properly specified and suitably fits the data.

Results:
Interpreting interaction terms leads to the follow findings: 1) rural roads with cloudy conditions are associated with relative increases in accident frequency; 2) lower/moderate AADT and rainy weather are associated with relative decreases in accident frequency, while high AADT and rain are associated with relative increases in accident frequency; 3) higher AADT and wider pavements are associated with relative increases in accident frequency; and 4) higher speed limits in residential areas are associated with relative increases in accident frequency.

Conclusion:
Results illustrate the complicated relationship between accident frequency and both roadway features and weather. Therefore, it is not sufficient to observe the effects of weather and roadway features independently as these variables interact with one another.