bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empathy and attitude towards communication skill learning as a predictor of patient-centered attitude: A cross-sectional study of dental students in Korea
Authors: Lee Minjung , Ihm Jungjoon 
Published: August 2020

Abstract
Background: Enhancing medical students’ practicing patient-centered care is a goal of medical schools. In addition to exploring the demographic and academic factors of the students, it is necessary to identify other attitudes and perceptions that may influence the student’s patient-centered attitude and inclination toward communication skill learning. This study aimed to assess patient-centered attitudes among dental students in Korea and identify the association between the students’ characteristics and empathy, communication skill attitude, and patient-centered attitude. Methods: Data were collected via a cross-sectional online survey, and 312 dental students were included in the analyses. The study participants completed the Patient-provider Orientation Scale (PPOS), the Interpersonal Reactivity Index (IRI), and the Communication Skills Attitudes Scale (CSAS). Analyses were performed using independent samples t-tests, hierarchical multi-variable regression, and ANOVA with a post-hoc Tukey test. Results: The students tend to be moderately doctor-centered toward the caring aspect and slightly more doctor-oriented toward the sharing aspect of patient-centered attitudes. Being male and a longer academic period in dentistry were related to a doctor-centered attitude. Empathy and attitude toward on learning communication skills were related to a patient-centered attitude and “empathic concern” had the greatest significant impact on patient-centered attitude. Conclusion: The current study supports the idea that education programs should focus on enhancing empathy, emphasizing positive attitudes on learning communication skills, and conducting follow-up education sessions to prevent students from becoming less patient-centered with an increase in duration of their academic period.
A Robotic End-Effector With Rolling up Mechanism for Pick-and-Release of a Cotton Sheet
Authors: Abe Taiki , Kawasaki Yuichi , Yamazaki Kimitoshi 
Published: August 2020

Abstract
In this paper we introduce a novel robotic end-effector for pick-and-release of a sheet of cotton cloth. One of the main operations in a factory for sewing cloth products is to pick up cloth parts, provide them to a sewing machine, and sew them together. Fabric products are assembled by performing this work in various processes. Each work starts with a lot of cloth parts stacked near a sewing machine. In the case of underwear, thin cotton cloth is the target of manipulation, but such cloth parts tend to stick to each other, and a certain knack is required for picking up. Therefore, this work is basically done manually in the present. The purpose of this study is to automate such manipulation, so we devise an end-effector that picks up only the top one of stacked cotton sheets. The proposed end-effector has a mechanism that is a cylindrical brush attached with a remover cloth on its surface. The cylinder brush is grounded on a cotton sheet, and then is rotated to roll up only the cotton sheet. This mechanism makes it possible to release the sheet by rotating the brush in the reverse. We constructed hardware with this function and attached it to the tip of a robotic manipulator. In addition, we performed system integration so that the initial position of rolling up a cotton sheet could be automatically determined from images taken by a camera. We also conducted evaluation experiments.
Prevalence and Determinants of Covert Contraceptive Use in Kenya: a Cross-Sectional Study
Authors: Akoth Catherine , Oguta James Odhiambo , Gatimu Samwel Maina 
Published: August 2020

Abstract
Background: Family planning (FP) is a key intervention for preventing unplanned pregnancies, unsafe abortions, and maternal death. Involvement of both women and their partners promotes contraceptive acceptance, uptake and continuation, couple communication and gender-equitable attitude. It is a key strategy for addressing about 17.5% of the unmet needs in FP in Kenya. This study assessed the prevalence and determinants of covert contraceptive use (CCU) in Kenya.Methods: We used data from the sixth and seventh rounds of the performance monitoring for accountability surveys. We defined CCU as ”the use of contraceptives without a partner’s knowledge”. We used frequencies and percentages to describe the sample characteristics and the prevalence of CCU and assessed the determinants using bivariate and multivariable logistic regressions.Results: Of the 3,892 married women using contraceptives included in this study, 62.9% were 20−34 years, 65.4% lived in rural areas, 51.3% had primary education and 82.4% had two or more children. The mean age at first sexual encounter was 17.3 years (standard deviation: 3.0). The prevalence of CCU was 12.2% (95% CI: 10.4%−14.2%) and was high among 35−49 years (12.8%), uneducated (22.3%) and poorest (18.2%) women. Siaya (22.9%), Kericho (16.7%) and Kakamega (13.1%) counties had the highest prevalence of CCU. Injectables (53.3%) and implants (34.6%) were the commonest methods among women who practice CCU. County of residence, education, wealth, parity, and age at sexual debut were associated with CCU.Conclusion: About one in 10 married women in Kenya use contraceptive covertly, with injectables and implants being the preferred methods. Our study highlights a gap in partner involvement in FP and calls for efforts to strengthen their involvement to increase contraceptive use in Kenya while acknowledging the rights of women to make independent choices.
Fast Site-to-site Electron Transfer of High-entropy Alloy Nanocatalyst Driving Redox Electrocatalysis
Authors: Li Hongdong , Han Yi , Zhao Huan , Qi Wenjing , Zhang Dan , Yu Yaodong , Cai Wenwen , Li Shaoxiang , Lai Jianping , Huang Bolong , Wang Lei 
Published: August 2020

Abstract
Designing electrocatalysts with high-performance for both reduction and oxidation reactions faces severe challenges. Here, the uniform and small size (~3.4 nm) high-entropy alloys (HEAs) Pt18Ni26Fe15Co14Cu27 nanoparticles (NPs) are synthesized by a simple low-temperature (<250 oC) oil phase synthesis strategy at atmospheric pressure for the first time. The Pt18Ni26Fe15Co14Cu27/C catalyst exhibits excellent electrocatalytic performance for hydrogen evolution reaction (HER) and methanol oxidation reaction (MOR). The catalyst is one of the best performance achieved by state-of-the-art alkaline HER catalysts, which shows an ultrasmall overpotential of 11 mV at the current density of 10 mA cm-2, excellent activity (10.96 A mg-1Pt at -0.07 V vs. reversible hydrogen electrode) and stability in the alkaline medium. Furthermore, it is also the most efficient catalyst (15.04 A mg-1Pt) ever reported for MOR in alkaline solution. DFT calculations confirm the multi-active sites for both HER and MOR on the HEA surface as the key factor for both proton and intermediate transformation. Meanwhile, the construction of HEA surfaces supplies the fast site-to-site electron transfer for both reduction and oxidation processes.
Blocked Pollen Release Prevents Fruit Formation in the Halophyte Elaeagnus Angustifolia in Non-Saline Habitats
Authors: Guo Jianrong , Wang Baoshan 
Published: August 2020

Abstract
Background: Anther development affects the reproduction of flowering plants. Halophyte Elaeagnus angustifolia can produce fruits when grown in saline soils. However, no fruits are produced in non-saline soils. The possible reasons and differences in E. angustifolia under two conditions were elucidated. Results: We examined features including pollen vitality and germination, in situ pollen germination after natural and hand pollination, anthers after pollen release, and the transcriptome in anthers. No significant difference was observed in pollen vitality or stigma receptivity in E. angustifolia in non-saline vs. saline habitats. However, no pollen tubes were present in styles, and pollen grains were abundant in E. angustifolia anthers under non-saline conditions. Notably, many pollen tubes formed in styles of E. angustifolia after hand pollination in the non-saline habitat. And the differentially expressed genes in anthers from saline vs. non-saline habitats were mainly related to phytohormones, cell wall secondary thickening, transcription factors and ion transport. Conclusions: E. angustifolia fail to form fruits in non-saline habitats due to poor anther pollen release. The induction and coordinated upregulation of genes related to anther cell wall formation and JA biosynthesis likely contribute to anther dehiscence in E. angustifolia in saline habitats, whereas anther dehiscence is blocked in plants grown in non-saline habitats.
Psychometric Properties of a Persian Version of Respectful Maternity Care Questionnaire
Authors: Esmkhani Mina , Namadian Masoumeh , Nooroozy Ali 
Published: August 2020

Abstract
Background: Getting a high quality and respectful care during pregnancy and delivery is one of the ways to reduce complications in women. Respectful care is a type of care that requires a valid instrument to measure. This study was conducted to determine the validity and reliability of the Persian version of the Respectful Maternity Care (RMC) questionnaire in 2018.Methods: This study was performed on 150 women (In the first 48 hours after delivery), who were admitted in the postpartum wards of public hospitals from 1st January until 6th April 2018 in Zanjan city in Iran. Participants were selected randomly using Poisson distribution (Time) sampling method. After receiving the permission from the questionnaire’s author, the internal consistency of the tool was measured by Cronbach's alpha coefficient after the Forward translation of Persian version of the tool under the supervision of experts. The reliability of the modified questionnaire was assessed using a test-retest method in 10 eligible postpartum women, who completed the same questionnaire after 72 hours again. The validity of the tool was confirmed by exploratory and confirmatory factor analysis using LISREL and SPSS soft wares. Results: The original RMC tool was achieved an overall high internal reliability (α =0.839). Confirmatory factor analysis of original RMC scores demonstrated poor fit indices. In LISREL proposed paths for model, one item was excluded and a re-exploratory factor analysis was performed with the remaining 14 items. Four new subscales were defined for the revised tool including Abusive Care, Effective Care, Friendly Care, and Respectful Communication , which explained 60% of the variance. Conclusions: The revised included four subscales of Abusive Care, Effective Care, Friendly Care, and Respectful Communication in 14 items which explained 60% of the variance. Given the importance of providing a high quality care in maternity, and variety of cultures and service delivery in different countries, further researches are needed on this RMC tool to be used in maternity care in different places.
DCZ0014, A Novel Compound in the Therapy of Diffuse Large B-Cell Lymphoma via the B Cell Receptor Signaling Pathway
Authors: Chang Shuaikang , Li Bo , Wang Yingcong , Feng Qilin , Xu Zhijian , Tao Yi , Wei Rong , Lu Yumeng , Zhang Yong , Xie Yongsheng , Lai Weiming , Wu Xiaosong , Zhu Weiliang , Shi Jumei 
Published: August 2020

Abstract
Background: Diffuse large B cell lymphoma (DLBCL) is a clinical and genetically heterogeneous lymphoid malignancy. Although the R-CHOP (rituximab plus cyclophosphamide, vincristine, doxorubicin, and prednisone) treatment can improve the survival rate of patients with DLBCL. However, more than 30% of patients exhibit treatment failure, relapse, or refractory disease. Therefore, novel drugs or targeted therapies are needed to improve the overall survival of patients with DLBCL. The compound DCZ0014 is a novel chemical similar to berberine, obtained by drug design and organic synthesis. Methods: The anti-DLBCL activity of DCZ0014 were investigated using assays of colony formation, CCK-8, TUNEL assay, EdU assay, cell cycle analysis, flow cytometry analysis, MMP analysis, Western blotting, immunohistochemistry and xenograft tumour model. Overexpression and knockdown of lyn in DLBCL cells was constructed with the small interfering RNAs or plasmid. The student's t-test was performed to the statistical analysis. Results: We found that DCZ0014 significantly inhibited the proliferation and activity of DLBCL cells, reduced the formation of their clones, and induced cell apoptosis. Following treatment with DCZ0014, DLBCL cells accumulated in G0/G1-phase of the cell cycle and showed decreased mitochondrial membrane potential. Additionally, DCZ0014 significantly inhibited DNA synthesis, enhanced DNA damage in DLBCL cells, as well as inhibited Lyn/Syk in B cell receptor signaling pathway. Further experiments demonstrated that DCZ0014 did not significantly affect peripheral blood mononuclear cells. In vivo analysis showed that DCZ0014 not only significantly inhibited tumor growth but also extended the survival time of mice in the DCZ0014-treated group. Conclusions: DCZ0014 showed potential for clinical application in the treatment of patients with DLBCL.
Mitophagy Promotes Sorafenib Resistance Through a Hypoxia-Inducible ATAD3A Dependent Axis
Authors: Wu Hong , Wang Tao , Liu Yiqiang , Li Xin , Wu Changtao , Zou Hongbo , Cao Mianfu , Jin Guoxiang , Wang Bin , Luo Xiaolin , Xu Chuan 
Published: August 2020

Abstract
BACKGROUND: The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here we identified hyperactivated mitophagy is essential for sorafenib resistance, and the mitophagy core regulator gene ATAD3A (ATPase family AAA domain containing 3A) was down regulated in the resistant hepatoma cells. Blocking mitophagy may restore the sorafenib sensitivity of these cells and provide a new treatment strategy for HCC patients.METHODS: Hypoxia induced sorafenib resistant cells were established by culturing under 1% O2 with increasing drug treatment. RNA sequencing was conducted in transfecting LM3 cells with sh-ATAD3A lentivirus. Subsequent mechanistic studies were performed in HCC cell lines by manipulating ATAD3A expression isogenically where we evaluated drug sensitivity, molecular signaling events. In vivo study, we investigated the combined treatment effect of sorafenib and miR-210-5P antagomir. RESULTS: We found a hyperactivated mitophagy regulating by ATAD3A-PINK/PARKIN axis in hypoxia induced sorafenib resistant HCC cells. Gain- and loss- of ATAD3A were related to hypoxia-induced mitophagy and sorafenib resistance. In addition, ATAD3A is a functional target of miR-210-5p and its oncogenic functions are likely mediated by increased miR-210-5P expression. The classic hypoxia-induced miRNA was upregulated during hypoxia-induced mitophagy and sorafenib resistance. In vivo xenograft assay showed that miR-210-5P antagomir combined with sorafenib abrogated the tumorigenic effect of ATAD3A down-regulation in mice. CONCLUSION: Loss of ATAD3A hyperactivates mitophagy which is a core event in hypoxia induced sorafenib resistance in HCC cells. Targeting miR-210-5P-ATAD3A axis is a novel therapeutic target for sorafenib-resistant HCC patients.
LncRNA NKX2-1-AS1 As ceRNA Promotes Tumor Progression and Angiogenesis by Upregulating SERPINE1 Expression and Activating VEGFR-2 Signaling Pathway in Gastric Cancer
Authors: Teng Fei , Zhang Juxiang , Chen Yi , Shen Xiaodong , Guo Yanjiao , Wang Puhua , Lei Ming , Cao Yiou , Liu Shao-Qun 
Published: August 2020

Abstract
Background: Recent evidence indicated that the lncRNA NKX2-1-AS1 (NKX2-1 antisense RNA 1) plays an important role in cancer progression and metastasis. However, the associated molecular mechanisms of NKX2-1-AS1 in GC are still unclear. Methods: To determine the target of the study by bioinformatic analysis. NKX2-1-AS1 expression was measured in paired tumor and non-tumor tissues of 178 GC patients, by quantitative reverse transcription PCR. The in vitro and in vivo biological functions of NKX2-1-AS1 were examined by loss-of-function and gain-of-function experiments. The potential mechanisms of this competing endogenous RNA (ceRNA) were elucidated using dual-luciferase reporter assay, quantitative PCR, Western blot, and fluorescence in situ hybridization (FISH). Results: NKX2-1-AS1 expression was upregulated in GC cell lines and tumor tissues, which was correlated with tumor progression and enhanced angiogenesis. Functionally, NKX2-1-AS1 overexpression promoted GC cell proliferation, metastasis, invasion, and angiogenesis, while NKX2-1-AS1 downregulation reversed these effects, both in vitro and in vivo. Bioinformatics analysis and dual-luciferase assay showed that the microRNA miR-145-5p is a direct target of NKX2-1-AS1, and that NKX2-1-AS1 acts as a ceRNA that regulates angiogenesis in the context of GC. The mechanistic study revealed that miR-145-5p specifically targets serpin family E member 1 (SERPINE1), and that the complex NKX2-1-AS1/miR-145-5p activates VEGFR2 signaling, via SERPINE1, to promote tumor proliferation and angiogenesis. Conclusion: NKX2-1-AS1 upregulation is associated with tumor cell proliferation, increased angiogenesis, and poor prognosis in GC patients. NKX2-1-AS1 regulates SERPINE1 expression and VEGFR2 signaling by acting as a ceRNA for miR-145-5p.
Development and Validation of the Suicide Behaviours Questionnaire – Autism Spectrum Conditions in Autistic, Possibly Autistic and Non-Autistic Adults.
Authors: Cassidy Sarah , Bradley Louise , Cogger-Ward Heather , Rodgers Jacqui 
Published: August 2020

Abstract
Background: Autistic people and those with high autistic traits are at high risk of experiencing suicidality. Yet, there are no suicidality assessment tools developed or validated for these groups.Methods: A widely used and validated suicidality assessment tool developed for the general population (SBQ-R), was adapted using feedback from autistic adults. The adapted tool was refined through 9 interviews, and an online survey with 251 autistic adults, to establish clarity and relevance of the items. Subsequently, 308 autistic, 113 possibly autistic, and 268 non-autistic adults completed the adapted tool online, alongside self-report measures of autistic traits (AQ), camouflaging autistic traits (CAT-Q), depression (PHQ-9), anxiety (ASA-A), thwarted belongingness and perceived burdensomeness (INQ-15), lifetime non-suicidal self-injury, and the original version of the suicidality assessment tool (SBQ-R). Analyses explored the appropriateness and measurement properties of the adapted tool between the groups.Results: There was evidence in support of content validity, structural validity, internal consistency, convergent and divergent validity, test retest validity, sensitivity and specificity (for distinguishing those with or without lifetime experience of suicide attempt), and hypothesis testing of the adapted tool (SBQ-ASC) in each group. The structure of the SBQ-ASC was equivalent between autistic and possibly autistic adults, regardless of gender, or use of visual aids to help quantify abstract rating scales.Limitations: The samples involved in the development and validation of the adapted tool were largely female, and largely diagnosed as autistic in adulthood, which is not representative of the wider autistic population. The SBQ-ASC has been developed for use in research and is not recommended to assess risk of future suicide attempts and/or self-harm.Conclusions: The SBQ-ASC is a brief self-report suicidality assessment tool, developed and validated with and for autistic adults, without co-occurring intellectual disability. The SBQ-ASC is appropriate for use in research to identify suicidal thoughts and behaviours in autistic and possibly autistic people, and model associations with risk and protective factors.
Health Consequences of Drought in The WHO Eastern Mediterranean Region: Hotspot Areas and Needed Actions.
Authors: Bellizzi Saverio , Lane Chris , Elhakim Mohamed , Nabeth Pierre 
Published: August 2020

Abstract
Background: Over the past four decades, drought episodes in the Eastern Mediterranean Region (EMR) of the of the World Health Organization (WHO) have gradually become more widespread, prolonged and frequent. We aimed to map hotspot countries and identified key strategic actions for health consequences.Methods: We reviewed scientific literature and WHO EMR documentation on trends and patterns of the drought health consequences from 1990 through 2019. Extensive communication was also carried out with EMR WHO country offices to retrieve information on ongoing initiatives to face health consequences due to drought. An index score was developed to categorize countries according vulnerability factors towards drought. Results: A series of complex health consequences are due to drought in EMR, including malnutrition, vector-borne diseases, and water-borne diseases. The index score indicated how Afghanistan, Yemen and Somalia are “hotspots” due to poor population health status and access to basic sanitation as well as other elements such as food insecurity, displacement and conflicts/political instability. WHO country offices effort is towards enhancing access to water and sanitation and essential healthcare services including immunization and psychological support, strengthening disease surveillance and response, and risk communication. Conclusions: Drought-related health effects in the WHO EMR represent a public health emergency. Strengthening mitigation activities and additional tailored efforts are urgently needed to overcome context-specific gaps and weaknesses, with specific focus on financing, accountability and enhanced data availability.
Prognostic Implications of Alcohol Dehydrogenases Inhepatocellular Carcinoma
Authors: Liu Xiangye , Kong Delong , Li Tingting , You Hongjuan , Kong Fanyun , Tang Renxian 
Published: August 2020

Abstract
Background
Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates worldwide. Alcohol dehydrogenases (ADHs) are huge family of dehydrogenase enzymes and associated with the prognosis of various cancers. However, comprehensive analysis of prognostic implications related to ADHs in HCC is still lacking and largely unknown.
Results
In our study, the expression profiles and corresponding clinical information of HCC from The Cancer Genome Atlas (TCGA) were used to evaluate the association between ADHs and outcomes of the patients. We found that the expression of ADH1A, ADH1B, ADH1C, ADH4, and ADH6 was significantly downregulated in HCC samples compared to normal liver samples. Our univariate and multivariate Cox regression analyses results showed that high expression of ADH1A, ADH1B, ADH1C, ADH4, and ADH6 was considered as an independent factor with an improved prognosis for the survival of HCC patients. Moreover, our Kaplan-Meier analysis results also revealed that high expression of AHD1A, ADH1B, ADH1C, ADH4, and ADH6 was significantly associated with good survival rate in HCC patients. In addition, GO, KEGG, and GSEA analyses unveiled several oncogenic signaling pathways were negatively associated high expression of ADHs in HCC.
Conclusion
Overall, our results provide the potential prognostic biomarkers or molecular targets for the patients with HCC.