bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking coping strategies to locally-perceived aetiologies of mental distress in northern Rwanda
Authors: Tamming Teisi , Otake Yuko 
Published: July 2020

IntroductionHow and why people in a particular setting turn to a specific coping strategy for their distress is pivotal for strengthening mental healthcare and this needs to be understood from a local point of view. Prior research in northern Rwanda documented common local concepts of distress for the population that cannot receive assistance despite severe adversities; however, the locally-perceived causes, manifestation and coping strategies and their associations are still unclear.MethodsThe qualitative study in the Musanze district, northern Rwanda, was informed by Interpretative Phenomenological Analysis. In-depth interviews were conducted with people with lived experience and those in close contact with people with lived experience of distress. Ethnographic observation was conducted and the analyses were complimented by an earlier ethnography in the same village.ResultsStudy participants (n=15) included community members with lived experience of mental distress and/or those with close friends or family with lived experience. The perceived manifestations of the mental distresses were diverse and the causal attributions shifted from more social, concrete and explainable (eg, loss) towards magical, more abstract and unexplainable (eg, poisoning). Finally, participants sought coping strategies in accordance with their causal attribution in ways that made sense to them.ConclusionThe coping strategies were chosen according to the perceived aetiology of the symptoms and they were perceived to be effective for their distress. Local coping strategies that match people’s help-seeking patterns should therefore be supported in policy and programmes. In Rwanda this requires a mutual training of medical professionals and traditional healers and establishing co-treatment within two parallel systems. This also requires the support for programmes and initiatives that strengthen positive interactions and change in circumstances.
Brane with transverse rotation and background fields: boundary state and tachyon condensation
Authors: Kamani Davoud 
Published: July 2020

AbstractThe boundary state corresponding to the Dp-brane with a transverse rotation in the presence of the Kalb–Ramond and tachyon background fields and a U(1) internal field will be constructed. We shall investigate effects of the open string tachyon condensation on this brane via its boundary state. We demonstrate that the background fields and transverse rotation cannot protect the brane against the collapse. Our calculations are in the context of the bosonic string theory.
Pannotia's mantle signature: the quest for supercontinent identification
Authors: Heron Philip J. , Murphy J. Brendan , Nance R. Damian , Pysklywec R. N. 
Published: July 2020

Abstract

A supercontinent is generally considered to reflect the assembly of all, or most, of the Earth's continental lithosphere. Previous studies have used geological, atmospheric and biogenic ‘geomarkers’ to supplement supercontinent identification. However, there is no formal definition of how much continental material is required to be assembled, or indeed which geomarkers need to be present. Pannotia is a hypothesized landmass that existed in the interval
c.
0.65–0.54 Ga and was comprised of Gondwana, Laurentia, Baltica and possibly Siberia. Although Pannotia was considerably smaller than Pangaea (and also fleeting in its existence), the presence of geomarkers in the geological record support its identification as a supercontinent. Using 3D mantle convection models, we simulate the evolution of the mantle in response to the convergence leading to amalgamation of Rodinia and Pangaea. We then compare this supercontinent ‘fingerprint’ to Pannotian activity. For the first time, we show that Pannotian continental convergence could have generated a mantle signature in keeping with that of a simulated supercontinent. As a result, we posit that any formal identification of a supercontinent must take into consideration the thermal evolution of the mantle associated with convergence leading to continental amalgamation, rather than simply the size of the connected continental landmass.
Can Molecular Imaging Measure T-cell Activation?
Authors: Choyke Peter L. 
Published: July 2020

Abstract
Successful immunotherapy usually depends on activation of T cells in the tumor microenvironment. However, ascertaining whether T-cell activation has occurred in vivo is difficult without invasive tissue sampling. Inducible T-cell costimulator (ICOS) is a specific marker of T-cell activation that can be imaged by radiolabeling an anti-ICOS antibody and performing PET scanning. Hopefully, this agent will be the first of many molecular imaging constructs that can determine whether T-cell activation has occurred and could be used in drug development and clinical trials of cancer immunotherapy.
See related article by Xiao et al., p. 3023
A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K-mutant Solid Tumors
Authors: Sullivan Ryan J. , Weber Jeffrey , Patel Sapna , Dummer Reinhard , Carlino Matteo S. , Tan Daniel S.W. , Lebbé Celeste , Siena Salvatore , Elez Elena , Wollenberg Lance , Pickard Michael D. , Sandor Victor , Ascierto Paolo A. 
Published: July 2020

Abstract

Purpose:
This open-label, dose-finding phase Ib/II study reports the safety and activity of the first combination use with BRAF inhibitor (BRAFi) encorafenib plus MEK inhibitor (MEKi) binimetinib in patients with BRAF V600E–mutant solid tumors.

Patients and Methods:
In phase I, the recommended phase 2 doses (RP2D) were established (primary objective). In phase II, the clinical activity of the combination at the RP2D was assessed (primary objective) in patients with BRAF-mutant metastatic colorectal cancer (mCRC), BRAFi-treated BRAF-mutant melanoma, and BRAFi-naïve BRAF-mutant melanoma.

Results:
A total of 126 patients with BRAF-mutant solid tumors were enrolled (phase I: 47 patients; phase II: 79 patients). The RP2D was encorafenib 450 mg once daily plus binimetinib 45 mg twice daily and pharmacokinetic data suggest that drug exposures of each agent were similar in combination compared with single-agent studies. In the phase II cohorts, confirmed responses were seen in two of 11 (18%) evaluable patients with mCRC, 11 of 26 (42%) evaluable patients with BRAFi-pretreated melanoma, and 28 of 42 (67%) BRAFi-naïve patients with melanoma. The most common grade 3/4 adverse event in phase II was increased alanine aminotransferase.

Conclusions:
The combination of encorafenib (450 mg) plus binimetinib (45 mg) showed acceptable tolerability and encouraging activity in patients with BRAF V600–mutant tumors, which led to the dose selection for the melanoma COLUMBUS study. The safety profile of the combination was consistent with other approved BRAFi plus MEKi regimens, with several differences, including lower rates of dose-limiting pyrexia, arthralgia, and photosensitivity.
Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study
Authors: Harrington Kevin J. , Kong Anthony , Mach Nicolas , Chesney Jason A. , Fernandez Beatriz Castelo , Rischin Danny , Cohen Ezra E.W. , Radcliffe Hoi-Shen , Gumuscu Burak , Cheng Jonathan , Snyder Wendy , Siu Lillian L. 
Published: July 2020

Abstract

Purpose:
The prognosis for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is poor, and only a minority of patients benefit from checkpoint immunotherapy. Talimogene laherparepvec (T-VEC), an oncolytic immunotherapy approved for advanced melanoma, in combination with pembrolizumab may yield enhanced antitumor activity over either agent alone.

Patients and Methods:
This was a phase Ib/III, multicenter trial testing intratumoral T-VEC combined with intravenous pembrolizumab in R/M HNSCC refractory to platinum-based chemotherapy. For phase Ib, primary endpoint was incidence of dose-limiting toxicity (DLT). Key secondary endpoints included objective response rate and progression-free survival per irRECIST, overall survival, and safety.

Results:
Thirty-six patients were enrolled into the phase Ib study. The data cut-off date was August 28, 2018. Median follow-up was 5.8 months (range, 0.3–24.2). One DLT of T-VEC–related fatal arterial hemorrhage was reported. Twenty (55.6%) and 21 (58.3%) patients experienced adverse events (AE) related to T-VEC and pembrolizumab, respectively. Besides the DLT, there were no treatment-related fatal AEs. A confirmed partial response was observed in 5 (13.9%) patients. Ten (27.8%) patients were unevaluable for response due to early death. Median PFS and OS were 3.0 months [95% confidence interval (Cl), 2.0–5.8] and 5.8 months (95% Cl, 2.9–11.4), respectively.

Conclusions:
The combination of T-VEC and pembrolizumab demonstrated a tolerable safety profile in R/M HNSCC. The efficacy with the combination was similar to that with pembrolizumab monotherapy in historical HNSCC studies. Phase III part of this study was not further pursued (ClinicalTrials.gov Identifier: NCT02626000).
Isaac Satanow (1732–1804) on Moral and Intellectual Perfection
Authors: Morlok Elke 
Published: July 2020

Abstract
Isaac ben Moshe Halevi (Isaac Satanow, 1732–1804) serves as an interesting example of how Jewish intellectuals offered alternative ways of entering the new era. Unlike other authors, Satanow does not explicitly concentrate on secularization or assimilation in his writing, but instead intends to revive traditional values and writing by putting them into a new cultural and intellectual framework. Satanow combines relevant topics from Jewish tradition with scientific discoveries, philosophical reasoning, and kabbalistic thought. An analysis of Satanow’s unique combination of literary and intellectual corpora from various periods and backgrounds offers a more nuanced picture of European Jewish intellectual history and challenges the grand narratives of scholarship. Furthermore, an awareness of the deep impact of German philosophy and natural science on Satanow’s thought provides insight into his relationship with the majority culture and his Eastern European background and also shows how his concept of modernity seeped in via complex networks.
Urocaridella arabianensis n. sp., a new Palaemonid shrimp (Crustacea, Decapoda, Palaemonidae) from Lakshadweep Islands, India with taxonomic comparison on the genus Urocaridella Borradaile, 1915
Authors: AKASH S. , PURUSHOTHAMAN P. , MADHAVAN MANU , RAVI CHARAN , HISHAM T. JAFER , SUDHAKAR M. , KUMAR T.T. AJITH , KULDEEP LAL K 
Published: July 2020

A new species of the genus Urocaridella Borradaile, 1915, Urocaridella arabianensis n. sp. is described and illustrated based on fifty-five specimens collected from the reef regions of Agatti Island, Lakshadweep, Arabian Sea. Urocaridella arabianensis n. sp. is morphologically close to U. pulchella Yokes & Galil, 2006, reported from the Mediterranean Sea. However, the present specimen is clearly distinguished with its rostrum length, which is 1.7 to 2.1 times as long as carapace, 10 ventral rostral teeth, carpus of 1st pereopod is 2.5 times long as palm, carpus of 2nd pereopod is 1.8 times as long as palm, presence of a spine in latero-middle of the fourth and fifth abdomens and the sixth abdominal segment is 2.3 times long as the fifth segment. Partial segment of the mitochondrial COI, 16S rRNA and nuclear gene 18S rRNA and H3 indicates that the new species is sister to a clade comprising of U. pulchella, U. antonbruunii and U. degravei. The pair wise genetic distance of COI showed great distance with the closest congeneric species.
Wide Gastric Conduit Increases the Risk of Benign Anastomotic Stricture After Esophagectomy
Authors: Zhu Dong-shan , Cao Jian-wei , Geng Ming-fei , Huang Xiao-yu , Hu Chong-ming , Li Jian , Fu Dong-hong , Liu Wei 
Published: July 2020

Background To identify the association between the width of the gastric conduit and the benign anastomotic stricture (BAS) after esophagectomy with end-to-side cervical anastomosis for esophageal cancer. Methods Patients with esophageal cancer who underwent esophagectomy between July 2013 and July 2014 were included in this study. The gastric conduit was used for reconstruction in all patients and end-to-side cervical anastomosis were performed using a circular stapler. The patients were divided into a narrow group (3-5 cm) and a wide group (>5 cm) based on the gastric conduit width. Univariate and multivariate logistic regressions were used to analyze the possible factors (patients’ age, gender, preoperative comorbidities, neoadjuvant chemotherapy, gastric conduit width, anastomotic leakage) that could affect the incidence of BAS. Results Two-hundred and one patients were included in this study. The median follow-up period was 29 months (17-58 months). Seven cases (3.5%) showed anastomotic leakage in the postoperative period and 38 patients (18.9%) developed BAS; all within the first year of follow-up. In univariate analysis, the width of the gastric conduit was the only risk factor for the development of BAS (odds ratio [OR] = 3.36, P = .005). In multivariate logistic regression analysis, the wide group was an independent significant risk factor for the development of BAS developing compared with the narrow group (OR = 2.84, P = .02). Conclusions A wide gastric conduit width (>5 cm) is an independent risk factor for the development of BAS after esophagectomy and stapled cervical end-to-side anastomosis for esophageal cancer.
Lessons Learned and Experiences Shared From the Front Lines: Milan and Madrid
Authors: Wexner Steven D. , Cortés-Guiral Delia , Spinelli Antonino , Mayol Julio 
Published: July 2020

Under the aegis of the American College of Surgeons (ACS), the senior author (SDW), a member of the Board of Regents of the ACS, interviewed 3 of his international colleagues in colon and rectal surgery who found themselves dealing with a flood of patients from the COVID-19 pandemic. Each was in a “hot spot” where the outbreak overwhelmed the capacities of the hospitals. Professor Antonino Spinelli of Milan dealt with the sudden increase in COVID-19 patients that threatened to push all other emergencies and urgent cancer cases aside. Providers lacked the personal protective equipment to be adequately safe in the environment. In Madrid, Dr Julio Mayol recounted how 10%-15% of the workers in his hospital were incapacitated by the virus, many of them doctors providing direct care to patients. The disease is so prevalent that all emergency patients are treated as though they have the infection. Having practices in Saudi Arabia and Spain, Dr Delia Cortés-Guiral saw how the former country controlled the epidemic through a strict lockdown of travel and closure of holy pilgrimage sites and social gatherings. In contrast, upon her return to her native country, she experienced the near-breakdown of the health care system by the suddenness of the outbreak. “There are now no specialists now, she says.” All of the specialties are treating COVID-19 patients and all of us are learning at the same time how to deal with this disease. “It is a nightmare now here in Spain”.
Immigration stress among refugees resettled in the United States
Authors: Kamimura Akiko , Weaver Shannon , Sin Kai , Pye Mu , Panahi Samin 
Published: July 2020

Background: Immigration stress includes acculturation stress and the stress related to language barriers, discrimination, occupational challenges, and feelings of isolation from society and a sense of newness or loss. Aims: The purpose of this study was to examine immigration stress among refugees resettled in the United States. Methods: A self-administered or interviewer-administered survey was collected from individuals with a refugee background in Utah from summer through fall in 2017 ( N = 190). Results: Older age was associated with higher levels of financial stress and homesickness. Poorer levels of self-rated health and fewer somatic symptoms were related to higher levels of homesickness and language barriers. Higher educational attainment was associated with higher levels of financial stress. Conclusion: Refugees are a vulnerable population due to being displaced to a foreign country and having to quickly learn a new language and different culture. It is imperative to gain more knowledge on diverse refugee groups and ways in which they can maintain optimum quality of life through and after the resettlement process.
Comparison of Coracoid Graft Position and Fixation in the Open Versus Arthroscopic Latarjet Techniques: A Cadaveric Study
Authors: Minuesa-Asensio Alvaro , García-Esteo Francisco , Mérida-Velasco José Ramón , Barrio-Asensio Carmen , López-Fernández Pedro , Aramberri-Gutiérrez Mikel , Murillo-González Jorge 
Published: July 2020

Background: Since the description of the arthroscopic Latarjet technique, discussion about the superiority of the open or arthroscopic procedure has arisen. The appropriate placement of the coracoid graft (CG) on the anterior glenoid neck is reported to be the most important step of the Latarjet procedure. Purpose: To verify if there are differences in the parameters that may affect the final position and fixation of CG obtained from the open and arthroscopic Latarjet techniques. Study Design: Controlled laboratory study. Methods: Twenty fresh-frozen human paired cadaveric shoulder specimens were randomly distributed in 2 surgery groups (open group [OG] and arthroscopic group [AG]) with 10 specimens in each. Two surgeons, each with experience performing open and arthroscopic Latarjet techniques, executed these procedures: one surgeon performed all open techniques, and the other performed all arthroscopic techniques, respectively. After surgery, a computerized tomography scan was performed. The surgical time, the position of each CG, a series of variables that might affect the CG fixation, and the level of the subscapularis muscle split were evaluated. Results: The mean surgical time was significantly longer in the AG (mean, 26 minutes for OG and 57 minutes for AG). Three intraoperative complications (30%) were identified in the AG, consisting of graft fractures. The CG was determined to be in an optimal cranial-caudal position in 90% of specimens of the OG and 44% of the AG (Fisher, P = .057). In both groups, the CG was placed in an optimal medial-lateral position in all specimens. In the OG, the degree of parallelism between the major axes of the glenoid surface and CG was significantly greater than in the AG (mean, 3.8º for OG and 15.1º for AG). No significant differences were observed in superior and inferior screw orientation between the groups. In the longitudinal and transverse directions, significant differences were found in the centering of the superior screw, being closer to the ideal point in the OG than in the AG. The location where the longitudinal subscapularis muscle split was performed was significantly higher in the AG. Conclusion: The open Latarjet technique required less surgical time; presented a lower number of intraoperative complications; and allowed more adequate placement of the CG, better centering of the screws, and a subscapularis muscle split closer to the ideal position. Clinical Relevance: The reported benefits of the arthroscopic Latarjet technique seem less clear if we take into account the added surgery time and complications.
Sex Differences in Anatomic Features Linked to Anterior Cruciate Ligament Injuries During Skeletal Growth and Maturation
Authors: Hosseinzadeh Shayan , Kiapour Ata M. 
Published: July 2020

Background: Several anatomic features of the knee have been shown to affect joint and anterior cruciate ligament (ACL) loading and the risk of subsequent injuries. While several studies have highlighted sex differences between these anatomic features, little is known on how these differences develop during skeletal growth and maturation. Hypotheses: (A) Anatomic features linked to an ACL injury will significantly change during skeletal growth and maturation. (B) The age-related changes in anatomic features linked to an ACL injury are different between male and female patients. Study Design: Cross-sectional study; Level of evidence, 3 Methods: After institutional review board approval, magnetic resonance imaging data from 269 unique knees (patient age 3-18 years; 51% female), free from any injuries, were used to measure femoral notch width, posterior slope of the lateral tibial plateau (lateral tibial slope), medial tibial depth, tibial spine height, and posterior lateral meniscal bone angle. Linear regression was used to test the associations between age and quantified anatomic indices. Patients were then divided into 4 age groups: preschool (3-6 years), prepubertal (7-10 years), early adolescent (11-14 years), and late adolescent (15-18 years). Also, 2-way analysis of variance with the Holm-Sidak post hoc test was used to compare morphology between male and female patients in each age group. Results: The femoral notch width, medial tibial depth, and tibial spine height significantly increased with age ( P < .001). The lateral tibial slope decreased with age only in male patients ( P < .001). Except for the posterior lateral meniscal bone angle, the age-related changes in anatomy were different between male and female patients ( P < .05). On average, early and late adolescent female patients had smaller femoral notches, steeper lateral tibial slopes, flatter medial tibial plateaus, and shorter tibial spines compared with age-matched male patients ( P < .01). Conclusion: Overall, the findings supported our hypotheses, showing sex-specific changes in anatomic features linked to an ACL injury during skeletal growth and maturation. These observations help to better explain the reported age and sex differences in the prevalence of ACL injuries. The fact that most of these anatomic features undergo substantial changes during skeletal growth and maturation introduces the hypothesis that prophylactic interventions (ie, activity modification) would have the potential to reshape a maturing knee in a manner that lowers the risk of noncontact ACL injuries.