bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABC5 International Consensus Conference on Advanced Breast Cancer, Lisbon, 16 November 2019
Authors: Untch Michael , Würstlein Rachel , Lüftner Diana , Haidinger Renate , Fasching Peter A. , Augustin Doris , Briest Susanne , Ettl Johannes , Förster Frank , Kurbacher Christian M. , Lück Hans-Joachim , Marschner Norbert , Müller Lothar , Müller Volkmar , Radke Isabel , Ruckhäberle Eugen , Scheffen Iris , Schumacher-Wulf Eva , Schwoerer Moritz , Steinfeld-Birg Dieter , Ziegler-Löhr Katja , Thomssen Christoph , Harbeck Nadia 
Published: June 2020

AbstractThe Advanced Breast Cancer Fifth International Consensus Conference (ABC5) which focuses on the diagnosis and treatment of advanced breast cancer was held in Lisbon on November 14 – 16, 2019. The aim of the conference is to standardize the treatment of advanced breast cancer worldwide using evidence-based data and to ensure that patients with advanced breast disease anywhere in the world are treated appropriately and have access to the latest therapies. This year, the emphasis was on new developments and study results from patients with advanced breast cancer as well as precision medicine. The collaboration with patient advocates from all over the globe is also an important goal of the ABC Conference, which is why the international ABC panel also included a number of patient advocates. We present a commentary on the voting results of the ABC5 panelists in Lisbon by a working group of German breast cancer specialists together with the implications for routine clinical care in Germany. The commentary is based on the recommendations of the Breast Commission of the German Gynecological Oncology Working Group (AGO). This commentary is useful, it includes country-specific features for the ABC consensus.
Klinische, diagnostische und therapeutische Aspekte der
Pachydermoperiostose (PDP): Ein Fallbericht
Authors: Morgenstern Thomas , Hammer Michael , Oji Vinzenz , Maier Anna 
Published: June 2020

ZusammenfassungDie Pachydermoperiostose (PDP; auch Primäre Hypertrophe
Osteoarthropathie (PHO) oder Touraine-Solente-Golé Syndrom) ist eine
extrem seltene hereditäre Erkrankung der Haut und gelenknahen
Knochen. Anhand des Falles eines 35-jährigen männlichen
Patienten mit Arthralgien und Pachydermie werden im Folgenden wesentliche
Aspekte zu Klinik, Diagnostik und Differenzialdiagnostik der Erkrankung
vorgestellt. Therapeutische Optionen beschränken sich im
Wesentlichen auf symptomatische Maßnahmen. Die Anwendung
spezifischer Therapien sind lediglich in Einzelfällen
beschrieben.
Nasal transmissible venereal tumours in 12 dogs – a retrospective study
Authors: Ignatenko Nataliia , Abramenko Irina , Soto Sara , Mueller Ralf , Boehm Teresa M. S. A. , Troedson Karin , Fejos Csilla , Hirschberger Johannes 
Published: June 2020

Abstract
Objective The aim of this study was a retrospective analysis of clinical manifestation and treatment outcome of the nasal form of transmissible venereal tumours (TVT).
Material and methods Twelve dogs suffering from nasal TVT were included in this study. Patients with primary genital lesions were excluded from the study. Signalment, physical examination and laboratory findings, results of further diagnostics, and treatment results were recorded in all patients.
Results The study population comprised 9 male and 4 female dogs with an (estimated) age ranging from 3 to 7 years. With one exception all dogs originated from Ukraine. Symptoms of nasal TVT included sneezing, nasal bleeding (all cases), skull infiltration (9 cases), oronasal fistulas (9 cases) and cutaneous fistulas (5 cases). Animals received vincristine sulfate at 0.7 mg/m2 i. v. weekly. The treatment course consisted of 4–9 cycles (median 5 cycles). Complete remission was achieved in all cases. All dogs were disease-free during the follow-up period (median 23.5 months, range 12–56 months). All patients tolerated the treatment very well.
Clinical significance In conclusion, our data suggest that nasal TVT can have a good response to vincristine treatment. TVT should be considered as a differential diagnosis in sneezing dogs with nasal discharge or bleeding especially in young dogs and in dogs with suspected nasal tumours, even in countries without a stray animal population.
Neuer Blick auf ein altes Element – Eisen, Hepcidin und Entzündung
Authors: Humann-Ziehank Esther 
Published: June 2020

ZusammenfassungEisen (Fe) ist ein essenzielles Spurenelement und nimmt in der tierärztlichen Praxis insbesondere durch seine Bedeutung bei der Eisenmangelanämie einen wichtigen Platz ein. Die Fe-Bereitstellung, z. B. für die Hämoglobinsynthese, stellt hohe Anforderungen an die Eisenhomöostase. Mit der Charakterisierung des Hepcidins als regulatives Protein des Eisenstoffwechsels wurde deutlich, dass Fe einer hormonähnlichen Regulation unterliegt. In der Leber gebildetes Hepcidin reguliert den membranständigen Fe-Transporter Ferroportin. Ein Anstieg der Hepcidinkonzentration führt zu einer Reduzierung der Abgabe von intrazellulär gespeichertem Fe in den Extrazellulärraum. Diese Internalisierung von Fe erfolgt vor allem im retikuloendothelialen System und in Monozyten/Makrophagen, aber auch die enterale Fe-Absorption wird durch Hepcidin vermindert. Auslöser für die hepatische Hepcidinsynthese sind nach derzeitiger Sicht einerseits hohe Fe- bzw. Transferrinkonzentrationen im Plasma. Aber auch Entzündungsmediatoren wie Zytokine führen zur gesteigerten Hepcidinsynthese. Hiermit wurde ein Erklärungsansatz für die oft beobachtete deutliche Abnahme der Fe-Konzentration im Plasma im Rahmen akuter Entzündungen entwickelt, der Mechanismus wird als sog. Zytokin-Hepcidin-Link bezeichnet. Da viele pathogene Mikroorganismen Fe für ihren eigenen Stoffwechsel benötigen, wird die über Hepcidin vermittelte Modulation der Fe-Verfügbarkeit mit Internalisierung von Fe in den Intrazellulärraum der unspezifischen Abwehr zugeordnet. Fe-Supplementationen durch den Tierarzt oder den Landwirt greifen in diese Regulation ein, doch gibt es bisher nur wenige Studien zu den klinischen und metabolischen Auswirkungen oraler oder parenteraler Fe-Supplementierung unter Einbeziehung des Hepcidins. Diese sollte zukünftig wissenschaftlich detaillierter beschrieben werden. Möglicherweise resultiert daraus eine Neubewertung der verschiedenen Formen der Fe-Gabe an Wiederkäuer, Schweine und/oder Pferde.
Wesen, Ursachen, Therapie und Prophylaxe der hypokalzämischen Gebärparese beim Rind
Authors: Khol Johannes L. , Moser Katharina , Miklis Alexandra , Dirisamer Michaela , Wittek Thomas 
Published: June 2020

ZusammenfassungDurch den laktationsbedingten sprunghaften Anstieg des Kalziumbedarfs nach der Geburt können hochleistende Milchkühe in eine hypokalzämische Stoffwechsellage geraten. Die Anfälligkeit für das Auftreten einer Gebärparese steigt dabei mit zunehmendem Alter der Tiere, hängt aber auch von zahlreichen anderen Faktoren wie dem Säure-Basen-Haushalt und der Versorgung mit Kalzium sowie anderen Mineralstoffen und Spurenelementen ab. Die Therapie erfolgt durch Kalziumapplikation, meist in Kombination mit Magnesium. Um die negativen Folgen des Kalziummangels zu vermeiden, sollte das Augenmerk jedoch auf dessen Prophylaxe liegen. Die peripartale orale Applikation von Kalziumverbindungen, eine der einfachsten Prophylaxemaßnahmen, ist mit einem hohen Arbeitsaufwand verbunden und setzt eine genaue Kenntnis des Geburtstermins voraus. Letzteres trifft auch für die parenterale Applikation von Vitamin D3 zu, die 1 Woche vor der Geburt erfolgen sollte. Zusätzlich birgt diese Methode bei wiederholter Anwendung die Gefahr einer Kalzinose. Die Verringerung des Kalziumangebots in der Trockensteherfütterung aktiviert die Mechanismen zur Kalziumhomöostase und stellt eine weitere Möglichkeit zur Prophylaxe der Gebärparese dar. Auch das gezielte Herbeiführen einer milden (kompensierten) metabolischen Azidose im Organismus, um die Sensitivität der Parathormonrezeptoren zu erhöhen und die Kalziumresorption im Darm zu steigern, kann zur Prophylaxe der Hypokalzämie eingesetzt werden. Hierzu dient eine sog. DCAD-Fütterung (DCAD = dietary cation anion difference) am Ende der Trockenstehperiode, bei der die Menge der starken Kationen (Kalium und Natrium) sowie der starken Anionen (Sulfat und Chlorid) beeinflusst wird. Dies geschieht entweder durch kaliumarme Fütterung (Teil-DCAD) oder den zusätzlichen Einsatz von sauren Salzen (Voll-DCAD). Insbesondere die Voll-DCAD ist mit einem nicht unerheblichen Analyse- und Kontrollaufwand verbunden. Je nach Inzidenz und Betriebsgröße sowie personellen und strukturellen Möglichkeiten gilt es daher, die am besten geeignete Methode zur Gebärpareseprophylaxe auszuwählen und umzusetzen.
Prostatakarzinom – chirurgische Komplikationen
Authors: Haidl Friederike , Al-Monajjed Rouvier 
Published: June 2020

ZusammenfassungDie radikale Prostatektomie (RP) als offener, laparoskopischer oder robotergestützter Eingriff stellt nach wie vor den kurativen „Goldstandard“ für Patienten mit einem lokal begrenzten Prostatakarzinom dar. Heutzutage wird die RP zudem als Erstbehandlung für ein lokal fortgeschrittenes Prostatakarzinom, eventuell im Rahmen eines multimodalen Settings mit adjuvanter Strahlen-/Hormontherapie angewendet. Die zunehmende Erfahrung der Chirurgen, die bessere Kenntnis der Anatomie und die Verfeinerungen der Operationstechniken haben die onkologischen sowie funktionellen Ergebnisse immens verbessert. In unserem Artikel möchten wir einen Überblick über die mit der Operation verbundenen Komplikationen geben.
Impact of the COVID-19 pandemic on gastrointestinal endoscopy activity in France
Authors: Belle Arthur , Barret Maximilien , Bernardini David , Tarrerias Anne-Laure , Bories Erwan , Costil Vianna , Denis Bernard , Gincul Rodica , Karsenti David , Koch Stephane , Laquiere Arthur , Lecomte Thierry , Quentin Vincent , Rahmi Gabriel , Robaszkiewicz Michel , Vaillant Eric , Vanbiervliet Geoffroy , Vienne Ariane , Dumeiran Franck , Gronier Olivier , Chaussade Stanislas ,   for the French Society of Digestive Endoscopy (Société Française d’Endoscopie Digestive)
Published: June 2020

Abstract
Background The SARS-CoV-2 pandemic has majorly affected medical activity around the world. We sought to measure the impact of the COVID-19 pandemic on gastrointestinal (GI) endoscopy activity in France.
Methods We performed a web-based survey, including 35 questions on the responders and their endoscopic practice, from 23 March to 27 March 2020, sent to the 3300 French gastroenterologists practicing endoscopy.
Results 694 GI endoscopists (21 %) provided analyzable data; of these, 29.4 % (204/694) were involved in the management of COVID-19 patients outside the endoscopy department. During the study period, 98.7 % (685/694) of endoscopists had had to cancel procedures. There were 89 gastroenterologists (12.8 %) who reported symptoms compatible with COVID-19 infection, and a positive PCR test was recorded in 12/197 (6.1 %) vs. 3/497 (0.6 %) endoscopists in the high vs. low prevalence areas, respectively (P < 0.001).
Conclusions The COVID-19 pandemic led to a major reduction in the volume of GI endoscopies performed in France in March 2020. The prolonged limited access to GI endoscopy could lead to a delay in the management of patients with GI cancers.
Posttraumatic Acute Spinal Epidural Hematoma of the Dorsolumbar Region
Authors: Agrawal Amit , V. Uma Maheshwara Reddy , Brinda Kuraparthy , Moscote-Salazar Luis R. , Dhanireddy Keerthana 
Published: June 2020

AbstractIn spite of the relative common occurrence of spinal injuries, spinal epidural hematomas (SEHs) are rare lesions. Depending on the onset, site, size, and presence of neurological deficits, they can be treated conservatively or surgically. In the presented article, we report an uncommon case of posttraumatic dorsolumbar SEH and discuss the characteristic magnetic resonance imaging (MRI) imaging findings of epidural fat in the cases of traumatic spinal hematomas.
Role of Hyperbaric Oxygen Therapy in Traumatic Brain Injury—Evidence-Based Consensus
Authors: Velho Vernon , Kharosekar Hrushikesh , Bhople Laxmikant , Palande Deepak A. 
Published: June 2020

AbstractTraumatic brain injury (TBI) is a major health problem in India and worldwide, resulting in significant morbidity, mortality, and disabilities of young and productive group of society. Various treatment modalities in the immediate period following a TBI are focused on altering the acute pathophysiology. Secondary injury is precipitated by ischemia resulting from decreased cerebral blood flow leading to hypoxia and is particularly likely to occur in the first 24 hours after injury. Hyperbaric oxygen therapy (HBOT) targets TBI-induced ischemia by exposing patients to an environment that substantially increases the amount of O2 inspiration (100% O2 at >1 atmosphere absolute), producing an increased O2 concentration in the plasma and thus increased delivery of O2 for diffusion to brain tissue. Despite the capacity of HBOT to protect against secondary ischemic damage, the use of HBOT for the treatment of TBI has been controversial. To gain acceptance in routine clinical use, a clinical method of assessing its effectiveness in the individual patient, computed tomography perfusion scan, single-photon emission computed tomography scans, and other intermediate indicators of the effects of HBOT should be examined by large and high-quality studies.
Analysis of Employee Patient Portal Use and Electronic Health Record Access at an Academic Medical Center
Authors: Sulieman Lina , Steitz Bryan , Rosenbloom S. Trent 
Published: June 2020

Abstract
Background Patient portals provide patients and their caregivers online access to limited health results. Health care employees with electronic health record (EHR) access may be able to view their health information not available in the patient portal by looking in the EHR.
Objective In this study, we examine how employees use the patient portal when they also have access to the tethered EHR.
Methods We obtained patient portal and EHR usage logs corresponding to all employees who viewed their health data at our institution between January 1, 2013 and November 1, 2017. We formed three cohorts based on the systems that employees used to view their health data: employees who used the patient portal only, employees who viewed health data in the EHR only, and employees who used both systems. We compared system accesses and usage patterns for each employee cohort.
Results During the study period, 35,172 employees accessed the EHR as part of patients' treatment and 28,631 employees accessed their health data: 25,193 of them used the patient portal and 13,318 accessed their clinical data in EHR. All employees who accessed their records in the EHR viewed their clinical notes at least once. Among EHR accesses, clinical note accesses comprised more than 42% of all EHR accesses. Provider messaging and appointment scheduling were the most commonly used functions in the patient portal. Employees who had access to their health data in both systems were more likely to engage with providers through portal messages.
Conclusion Employees at a large medical center accessed clinical notes in the EHR to obtain information about their health. Employees also viewed other health data not readily available in the patient portal.
Intensive Care Unit Setup for COVID-19
Authors: Panse Shweta , Kanchi Muralidhar , Chacko Jose , S. Srinath Kumar T. , Ramanjaneya Ranganatha , Wilben Viju , Alva Arjun , Shetty Deviprasad 
Published: June 2020

AbstractThe coronavirus pandemic has become a challenge to all the healthcare systems in the world. Urgent creation of an intensive care unit (ICU) for the same is the need of the hour. The ideal ICU for COVID -19 should be isolated, fully equipped with invasive and noninvasive monitoring, with 24/7 trained medical personnel, nursing staff and laboratory support. As the coronavirus infection is transmitted by droplets and is highly contagious, protection of healthcare workers is crucial. Personnel working inside the ICU should get personal protective equipment (PPE). Strict guidelines for donning and doffing of PPE should be followed to prevent cross-contamination. Respiratory failure being the commonest complication of COVID-19, knowing the ventilator management for the same is essential. It is of great importance to meticulously manage all the resources to combat this contagion.
Human detection with and without weapon using LTE-based passive Forward Scattering Radar System
Authors: Hafizah Abdul Aziz Noor , Firdaus Hussain Muhammad 
Published: June 2020

Abstract
Firstly, radar is a system that has a radio transmitter that transmits radio waves, which will be received by a receiver, and it is used for detecting and locating objects. The passive radar system only receives signal from existing transmitters such as telecommunication antenna by using radio signal for tracking, detecting and so on. This experimental study was conducted with a human holding a weapon representing intruders that cross borders illegally into the country. Existing commercial telecommunication antenna was used as the transmitter transmitting the electromagnetic waves, and the system received the waves by using the receiver antenna. There are many techniques for a passive radar but in this case, we used the forward scattering region to detect human with and without weapon. The Doppler signature from human detection is produced when the receiver antenna detects any presence of a human that passes through between the transmitter and receiver. Two LTE frequencies used in this experimental work were 1.8 GHz and 2.63 GHz with several providers and have wider LTE coverage. The data from human detection was collected using LTE based passive forward scattering radar system, and was then analysed using Matlab programme. Principal Component Analysis (PCA) was used to classify the human without weapon and human holding a weapon into two categories. This system successfully classified the human with and without weapon and could be used by the military for border protection.
Investigation on fiber optic sensor using FBG for various temperature and liquid density
Authors: Idris S. K. , Haroon H. , Abdul Razak H. , Mohd Zain A. S. 
Published: June 2020

Abstract
There are several issues that present in conventional sensor including its accuracy, safety, durability and RF effect. These issues could be minimized with the implementation of fiber optic sensor. This project is to design and implement optical sensor using FBG for various temperature and liquid density sensing. The FBG sensor was submerged in liquid substances to determine the sensing conditions. The available pigtail was connected to the circulator, 1550nm laser source and optical spectrum analyzer (OSA). The data regarding temperature and density sensing captured from OSA were observed and analyzed. It is found that the relationship between the change in temperature and the change in wavelength is virtually linear in both environments making FBG a good candidate for sensing temperature.
Performance improvement of a slotted square patch antenna using FSS superstrate for wireless application
Authors: Nassr Z. A. , Zabri S.N. , Shairi N. A. , Zakaria Z. , Othman A. , Zobilah A. M. 
Published: June 2020

Abstract
This paper presents a wideband planar antenna integrated with a frequency selective surface (FSS). Initially, the FSS array screen is investigated using a basic square ring to construct a unit cell of the FSS periodical structure with a (12x12) array. FR4 with a permittivity of 4.7 and a thickness of 1.6 mm is used as the substrate material for both FSS structure and antenna. Then, the antenna is placed closely parallel over the FSS configuration at a distance of 28 mm. After analyzing the performance of the antenna in terms of return loss, directivity and antenna gain, the design is integrated with the FSS structure in order to achieve a stable frequency response. Directivity and gain improvement of 6.5 dB and 5.1 dB respectively are observed along broadside direction.
Mobile applications in customer relationship management to enhance empowerment of knowledge to customers
Authors: Gani Z , Maung W 
Published: June 2020

Abstract
The mobile application is in rapid growth and dissemination in business and enhancement of customer satisfaction has emerged as a core issue. In Customer Relationship Management (CRM), customer reviews are recognized as fruitful information sources for monitoring and enhancing customer satisfaction levels, in particular, feedback of actual customers expressing their opinion reflects on core business. Customer knowledge about products or services also reflects on the business. Knowledge is one of the key factors for customer service success - most companies would empower employees with knowledge which is deemed reasonable. The knowledge of technical intricacies and variables in finding an accurate Uninterruptable Power Supply (UPS) by customers has been a challenging task. This challenge via using a UPS calculator that computes upon different back-up time and technical calculations involved, allows customers to find an accurate UPS easily and gives the customers the ownership of the knowledge. This UPS calculator has created a niche market for UPS manufacturing and distributing companies. The feedback from the telephone interview conducted in this study shows that the customer using this UPS calculator can make an accurate decision-making process of purchasing a UPS and electrical wholesalers can give advice to customers to suitable UPS and prices with an improved business process. In the future, this research would like to extend its study towards customer interaction, customer satisfaction and customer value.
Lymphoblast cell morphology identification to detect Acute Lymphoblastic Leukemia (ALL) using various color segmentation
Authors: Nabilah Mohd Safuan Syadia , Razali Md Tomari Mohd , Nurshazwani Wan Zakaria Wan , Othman Nurmiza 
Published: June 2020

Abstract
Acute Lymphoblastic Leukemia (ALL) is a disease that is defined by the uncontrollable growth of abnormal cell of lymphocyte, which is called lymphoblast. ALL patients cannot be left untreated as it can be fatal, and hence, early detection is very crucial for proper treatment suggestion. Conventionally, ALL analysis is manually done, which is time-consuming and highly dependent on the pathologist’s skills. Furthermore, it will be hard to pathologist as the number of sample increases, and also there are other cells inside the blood smear image, which will create confusion to them. Haematology counter is great to assist the process, but unfortunately, the cost is unbearable for some countries. For that reason, in this project, a computer-aided ALL detection with fast response is proposed. The system consists of five main modules which are image acquisition, pre-processing, segmentation, feature extraction and classification. For the process flow, firstly the color space correction based on l*a*b* color space is applied to standardize the color of the input image. Next, WBC segmentation is employed to locate the WBC region and consequently divided it into two parts which are the nucleus and cytoplasm based on a combination of color space analysis and Otsu thresholding. However, the segmented image contains noises and hence, is eliminated by using a combination of morphological filter and Connected Component Labelling (CCL). Then, the feature extraction process is made to study the nature of each individual cell using features derive from color, texture and geometrical properties. Lastly, lymphoblast classification is incurred to categorized the lymphoblast and the non-lymphoblast cell by employing Support Vector Machine (SVM) with a linear kernel function. As mentioned before, WBC segmentation is divided into two parts, and nucleus detection accuracy is higher than cytoplasm detection accuracy, which is 98.87% and 74.12% respectively. The presence of color space correction is analyzed, and the result is better with 96.92% accuracy for the presence of color space correction compared to 93.55% accuracy for without color space correction result. Classification performance is able to achieve 98.72% of accuracy.