bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pensar o Brasil: novos tempos para ciência, tecnologia e inovação
Authors: Goncalves do Amaral Marcelo , Fisher Bruno Brandão , Carvalho Rodrigo Da Silva , E Oliveira Virgílio Cézar Da Silva 
Published: May 2020

No limiar do vigésimo ano do novo século e milênio, um grande conjunto de mudanças é sentida em nossa sociedade, tanto em nível nacional quanto em âmbito global. O aprofundamento da transformação digital, iniciada há quarenta anos, as crises políticas e econômicas dos estados-nações, refutam completamente a ideia do fim da historia e da hegemonia norte-americana, abrindo espaço para uma nova dualidade ocidente-oriente. Nesse contexto, pensar o papel do Brasil em sua inserção na política internacional e nas cadeias globais de valor é essencial. Entretanto, pouca discussão tem sido feita sobre tais temas para se definir uma estratégia nacional. Em paralelo, discussões importantes sobre a configuração e financiamento dos entes de C&T&I do país foram trazidas à tona sem o devido cuidado e vêm gerando uma série de desconfortos e pânicos sobre o futuro de nossas instituições. Ao mesmo tempo que os setores mais dinâmicos da economia aceleram sua integração internacional, outros vão ficando cada vez mais distantes, assim fatiando o país em camadas ou grupos sociais que vivem em condições altamente heterogêneas em termos de desenvolvimento socioeconômico. Tal situação representa um fenômeno difícil de ser compreendido e tolerado à luz do conceito de cidadania - e de difícil reversão, ainda que políticas de equidade sejam empreendidas. Sem fazer juízo de valor, a RASI se posiciona como um instrumento de discussão, acadêmico e profissional, das temáticas relevantes para o avanço da administração, da inovação e da sociedade em sentido amplo.
KAMU HARCAMALARI VE SOSYOEKONOMİK GELİŞMİŞLİK DÜZEYLERİ BAKIMINDAN İLLERİN GRUPLANDIRILMASI: TÜRKİYE ÜZERİNE BİR UYGULAMA
Authors: ATILGAN YAŞA Ayşe , YÜZBAŞI KÜNÇ Gonca 
Published: May 2020

Bu çalışmada, Türkiye’de sosyoekonomik gelişmişlik göstergeleri dikkate alındığında öne çıkan iller ile kamu hizmetlerinden yararlanan illerin olası benzerlik ve farklılıklarının tespiti amaçlanmıştır. Çalışma kapsamında 2018 yılına ait kamu harcamaları fonksiyonel açıdan ele alınmış ve ilgili değişkenlere ilk olarak çok değişkenli istatistikî yöntemlerden çok boyutlu ölçekleme analizi ve kümeleme analizi uygulanmıştır. Sonrasında illere ait sosyoekonomik değişkenler ele alınarak çok boyutlu ölçekleme analizi ve kümeleme analizi kullanılmıştır. Çalışma, yapılan uygulamalar sonucu elde edilen benzerlik ve farklılıkların değerlendirilmesiyle devam etmiştir. Çalışma sonucunda, söz konusu illerin sosyoekonomik gruplanmalarıyla kamu harcamalarına ait gruplanmalarının birebir olmasa da paralele yakın sonuçlar verdiği görülmüştür. Ancak bazı illerin sosyoekonomik açıdan daha gelişmiş düzeyde iken kamu harcamaları açısından daha düşük seviyede olduğu görülmüştür. Bazı illerin ise sosyoekonomik açıdan diğer illere göre daha az gelişmişlik seviyesindeyken kamu harcamaları açısından daha yüksek seviyede olduğu tespit edilmiştir.
The Stratigraphic Architecture of Small Incised Valleys Along an Active Margin: Examples from the Oceanside Littoral Cell of the Southern California Coast
Authors: King Baird L. , Simms Alexander R. , Simkins Lauren M. 
Published: May 2020

Abstract
Compared to their equivalents along passive margins, less is understood about the stratigraphic architecture of incised-valley fill along active margins. Using approximately 10 km of shallow-marine seismic data and five vibracores, we compare the coastal incised-valley fill of two small southern California mountainous streams within the slowly uplifting and semiarid Oceanside Littoral Cell to incised-valley fill models from other active and passive margins. Our seismic data images the upper 16 m of the valley fill and contains three seismic units. The top unit is composed of a discontinuous drape of high-amplitude discontinuous subparallel reflections between 0.2 to 2 m thick, assuming a seismic velocity of 1500 m/s. The second unit is a 5.5- to 8-m-thick unit of faint chaotic reflections discontinuously compartmentalized by higher-amplitude mounded reflections. The lowest unit recorded in the seismic data is composed of a series of faint horizontal continuous reflections. A prominent reflector at 10 m separates the middle chaotic seismic unit from the lowest seismic unit. The shallow vibracores sampled the upper two seismic units, revealing a moderately well-sorted fine to very fine sand overlain by two silty units. The upper silt unit is bioturbated while the lower silt unit is well-laminated with laminations of gypsum sand. We interpret the silty units to represent a well-flushed mudflat overlying an enclosed evaporative mudflat. The second of these two facies appears to be unique to southern California estuaries undergoing uplift as an equivalent facies is not found within the estuaries developed within subsiding basins of the southern California coast. The sandy unit is interpreted to represent sandy lagoon or sandflat deposits. No cores sampled the lowest seismic unit; however, based on previously published data from neighboring incised valleys, we interpret it to be an open-estuary/central basin deposit. The fill within these small incised valleys is similar to that found along passive margins. The architecture of the valley fill is not dominated by tectonics but by eustatic sea-level rise. It lacks the multiple progradational phases and large volumes of coarse clastics common to other incised-valley fills from active margins. We attribute this difference to the generally low rates of uplift along this portion of the coast.
Tectonic Evolution of the Palos Verdes Fault–Lasuen Knoll Segment, Offshore Southern California
Authors: Thompson Michael , Francis Robert D. 
Published: May 2020

Abstract
Seismic mapping indicates that Lasuen Knoll in the Inner Borderland, offshore southern California, is a pop-up structure associated with a restraining stepover of the Palos Verdes Fault. Dextral shear is apparently transferred southeast through a complex zone of faults that includes the Carlsbad Ridge and Coronado Bank faults. This model is supported by comparison with other pop-up structures in the Inner Borderland and analogs to published sandpack laboratory simulations.
The Palos Verdes Fault along Lasuen Knoll has existed at least since the late Miocene Epoch (5 to 8 Ma) and is contemporaneous with the segment of the Palos Verdes Fault on San Pedro Shelf and adjacent to the Palos Verdes Peninsula. Isochore maps of stratigraphic intervals indicate that extension occurred locally along the Palos Verdes Fault adjacent to the present Lasuen Knoll pop-up during the Mohnian Stage and became more widespread during the Delmontian Stage (approximately 7.5 to 5 Ma). Repettian strata onlapping Lasuen Knoll indicate that the knoll began to form as a pop-up structure by the early Repettian (entire stage approximately 5 to 2.3 Ma) and has been active possibly until the Holocene.
Transtensional zones occur along the Palos Verdes–Carlsbad Ridge–Coronado Bank Fault Zone north and south of Lasuen Knoll. The San Gabriel Transtensional Zone, north of Lasuen Knoll, separates the knoll from the Palos Verdes Anticlinorium, the other major uplift structure along the Palos Verdes Fault. The Lasuen Knoll basement high, the overall structural high that includes Lasuen Knoll, is similar in dimension and shape to the Palos Verdes Anticlinorium, which has been interpreted to be underlain by a low-angle ramp fault. Recent models of low-angle ramp faults as major causes of the uplift of Palos Verdes, however, cannot be readily applied to Lasuen Knoll.
On the Relationship among Submarine‐Channel Stacking Patterns, Environmental Controls during Deposition, and Reservoir Architecture: Case Studies of Three Neogene Outcrops in Southern California
Authors: Pyles David R. , Schwartz Daniel E. , Bouroullec Renaud , Jennette David C. , Gordon Gregory S. 
Published: May 2020

Abstract
A quantitative model for categorizing submarine-channel stacking patterns is developed and applied to well-exposed outcrops of Neogene-aged submarine channels in the Capistrano and upper Monterey formations, Southern California. Three outcrops are characterized in terms of their stratigraphic architecture: (1) Point Fermin, (2) Dana Point Harbor, and (3) San Clemente State Beach. Each outcrop has a unique channel-stacking style. The channel elements at Point Fermin stack in a vertical, disorganized pattern; the channel elements at Dana Point Harbor stack in a mixed vertical–lateral, disorganized pattern; and the channel elements at San Clemente State Beach stack in a predominantly lateral, organized pattern. The different stacking styles are compared and contrasted using a method that quantifies channel-stacking patterns by normalized vertical and lateral offset. First-order controls on channel-stacking patterns are interpreted to be position on the physiographic profile, accommodation regime, and/or local changes in subsidence due to syndepositional faulting. The discrete channel-stacking patterns in the three outcrops closely relate to parameters relevant in subsurface reservoir characterization, such as net-sand content, connectivity of channel elements, and preservation potential.
A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis
Authors: Petersen Ivo , Chiummo Rafael , Zschiesche Eva , Karas-Tecza Joanna , Rapti Dhimiter , Roepke Rainer , Thomas Emmanuel 
Published: May 2020

Abstract
Background : Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. Controlled field studies are needed to confirm this potential. A study was therefore initiated to investigate the efficacy of a single oral or spot-on treatment with fluralaner, an isoxazoline, compared with multiple topical treatments with imidacloprid-moxidectin, in dogs naturally affected by generalized demodicosis. Methods : Veterinary clinics in 5 European countries enrolled 134 dogs diagnosed with generalized demodicosis. Dogs were randomized to treatment with either fluralaner chewables, fluralaner spot-on, or topical imidacloprid-moxidectin in a 2:2:1 ratio. Both fluralaner formulations were administered once, at the approved dose rate, on day 0. Imidacloprid-moxidectin was administered per label on day 0, and every 4 weeks, more frequently if necessary. At each visit (days 0, 28, 56, 84), dogs were monitored for demodectic mites, using deep skin scrapings, and observed for health and for severity of skin lesions. Treatment was considered efficacious if more than 90% of the dogs were free of live mites at both days 56 and 84. Results : Of 124 dogs completing the study, 57 were diagnosed with juvenile-onset demodicosis and 67 with the adult-onset form. A single treatment with oral or spot-on fluralaner was efficacious, each eliminating mites from at least 98.0% of treated dogs on days 56 and 84. Against juvenile-onset demodicosis, efficacy of the oral and spot-on formulations was 96.0% and 100%, respectively, and against adult-onset demodicosis 100% and 96.7%. Multiple administrations of imidacloprid-moxidectin were not efficacious, eliminating mites from 87.5% of dogs (92.0% with juvenile-onset demodicosis cured; 81.8% with adult-onset demodicosis). All groups showed a marked reduction in skin lesions by day 28, with continuing clinical improvement at each subsequent visit through day 84. There were no treatment-related adverse events. Conclusion : A single administration of fluralaner chewables or fluralaner spot-on is highly effective against juvenile-onset and adult-onset forms of generalized canine demodicosis. Topically applied imidacloprid-moxidectin at weekly to monthly intervals over the 84-day study did not achieve the proportion of mite-free dogs required to demonstrate efficacy.
Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: A cross-sectional analysis of a prospective hospital-register study.
Authors: Lavados Pablo M. , Mazzon Enrico , Rojo Alexis , Brunser Alejandro M. , Olavarría Verónica V. 
Published: May 2020

Abstract
Background: High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity.Aim: To investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.Methods: We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0-6 points) or high (7-14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet. Results: 368 patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1-9) and the median MEDAS score was 6 (IQR 4.5-8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = -0.19, p=0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37-0.98, p=0.04). Conclusions: Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.
Multilevel resistive switching memory based on a CH3NH3PbI3-xClx film with potassium chloride additives
Authors: Lv Fengzhen , Ling Kang , Zhong Tingting , Liu Fuchi , Liang Xiaoguang , Zhu Changming , Liu Jun , Kong Wenjie 
Published: May 2020

Abstract
High-quality CH3NH3PbI3-xClx (MAPIC) films were prepared using potassium chloride (KCl) as an additive on indium tin oxide(ITO)-coated glass substrates using a simple one-step and low-temperature solution reaction. The Au/KCl-MAPIC/ITO/Glass devices exhibited obvious multilevel resistive switching behavior, moderate endurance, and good retention performance. Electrical conduction analysis indicated that the resistive switching behavior of the KCl-doped MAPIC films was primarily attributed to the trap-controlled space-charge-limited current conduction that was caused by the iodine vacancies in the films. Moreover, the modulations of the barrier in the Au/KCl-MAPIC interface under bias voltages were thought to be responsible for the resistive switching in the carrier injection trapping/detrapping process.
miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14
Authors: Ding Li , Gao Xiang , Yu Shenghui , Sheng Liufang 
Published: May 2020

Abstract
Background: To investigate the mechanism of miR-128-3p and MAPK14 on the protective effect of dexmedetomidine on acute lung injury in septic mice.Methods: SPF C57BL/6 mice were divided into 8 groups. The pathological changes and wet/dry weight ratio (W/D), PaO2, PaCO2, MDA, SOD and MPO levels in lung tissue and the serum levels of inflammation factors were observed. Dual luciferase reporter assay was used to verify the targeting relationship between miR-128-3p and MAPK14. qPCR and WB were used to detect the expression of miR-128-3p and MAPK14.Results: Compared with the Normal group, other groups had lower MDA, MPO, inflammatory factors levels and the expression level of MAPK14, while the content of SOD and the expression level of miR-128-3p was significantly decreased. DEX treatment and up-regulation of miR-128-3p could significantly decrease the contents of MDA, MPO, inflammatory factor levels and significantly increase the SOD content in model mice, however, MAPK14 over-expression had opposite effects. miR-128-3p up-regulation enhanced the changes of above indicators caused by DEX treatment and MAPK14 over-expression could block the protective effect of DEX on acute lung injury in septic mice. miR-128-3p up-regulation reversed the effects of MAPK14 over-expression in model mice.Conclusion: miR-128-3p can further enhance the protective effect of dexmedetomidine on acute lung injury in septic mice by targeting and inhibiting MAPK14 expression.
Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis
Authors: He Yuqing , Deng Jiaxin , Zhao Yi , Tao Huiqian , Dan Hongxia , Xu Hao , Chen Qianming 
Published: May 2020

Abstract
Background Photodynamic therapy (PDT) is a new option for oral lichen planus (OLP) management; however, there are different opinions on the efficacy of PDT for OLP. The aim of this study was to comprehensively assess the efficacy of PDT in the treatment of OLP and compare PDT with steroid therapy. Methods A systematic review and meta-analysis were conducted to assess the curative effect of PDT. Five electronic databases were searched, PubMed, Web of Science, the Cochrane Library, Embase, and EBSCO up to 1 December, 2019. Random and fixed effects models for pooled estimates calculation were used and the Meta package of R was applied. Results Pooled estimates revealed that, after PDT, the lesion size decreased by 1.53 cm2 (95% confidence interval (CI): 0.71–2.35) after PDT and the partial response (PR) was 0.77 (95% CI: 0.65–0.85). The visual analogue scale (VAS) score decreased by 3.82 (95% CI: 2.80–4.85) and the Thongprasom sign score decreased by 1.33 (95% CI: 0.56–2.10) after PDT. Subgroup analyses revealed that the 5-aminolevulinic acid (5-ALA) was more effective than methylene blue (MB), with a PR of 0.87 (95% CI: 0.80–0.91). The topical use of 5-ALA yielded a better response than gargling methylene blue. In terms of VAS, the diode laser showed a better clinical PR in the treatment of OLP. In terms of changes in lesion size, the efficacy of the semiconductor laser was higher than that of the diode laser. PDT had a similar efficacy to topical corticosteroids, as shown by pooled estimates of five randomised controlled trials with 139 lesions. Conclusion PDT could be a valuable optional treatment for the management of OLP. And the results indicated that the curative effect of PDT is similar to that of topical corticosteroids in the treatment of OLP.
Impact of Mouse Strain and Sex when Modeling Radiation Necrosis
Authors: Boria Andrew J. , Perez-Torres Carlos 
Published: May 2020

Abstract
Background: Murine models are among the most common type of preclinical animal models used to study the human condition, but a wide selection of different mice is currently in use with these differences potentially compromising study results and impairing the ability to reconcile interstudy results. Our goal was to determine how the train and sex of the mice selection would affect the development of radiation necrosis in our murine model of radiation-induced cerebral necrosis. Methods: We generated this model by using a preclinical irradiator to irradiate a sub-hemispheric portion of the brain of mice with single-fraction doses of 80 Gy. Eight possible combinations of mice made up of two different with two substrains each(BALB/cN, BALB/cJ, C57BL/6N, and C57BL/6J) and both sexes were irradiated in this study. Radiation necrosis development was tracked up to eight weeks with a 7T Bruker MRI utilizing T2-weighted and post-contrast T1-weighted imaging. MRI results were compared to and validated with the use of histology which utilized a scale from 0-3 in ascending order of damage. Results: Both time post-irradiation and strain (BALB/c vs C57BL/6) were significant factors affecting radiation necrosis development. Sex was in general not a statistically significant parameter in terms of radiation necrosis development. Conclusion: Mouse strain thus need to be considered when evaluating the results of necrosis models. However, sex does not appear to be a variable needing major consideration.
Single Nucleotide Polymorphisms Associated With Prostate Cancer Development in Saudi Males
Authors: Osman Awad , Ahmed Atif Ali , Elbagir Asim Ali 
Published: May 2020

Abstract
Background: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PC). In this study, we investigated a group of SNPs in Saudi individuals and compared their frequency in patients and healthy normal controls. Methods: A total of 320 individuals were included in the study: 85 with PC, 120 with benign nodular hyperplasia, and 115 healthy normal controls. DNA was extracted from paraffin-embedded formalin-fixed tissue from PC and nodular hyperplasia patients and from whole blood of healthy controls. A total of thirteen SNPs were genotyped using the TaqMan® MGB PCR assay. Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequencies in PC patients than in controls (p < 0.05). The C/A genotype of the rs16901979 SNP was observed significantly more frequently in PC patients than in controls (43% vs 14%, OR = 0.2, p value = 0.0001) and more frequently in PC patients than in the benign hyperplasia group (43% vs 25%, OR = 2.3, p value = 0.03). Conclusion: Our study highlighted several SNP genotypes associated with PC development in Saudi males. These findings have important implications for diagnosing PC and screening unaffected family members of Saudi patients.