bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA DUXAP8 regulates the cell proliferation and invasion of non-small-cell lung cancer
Authors: Yang Si-Jia , Weng Jia-Lu , Wei Bin , Du Xue-Kui 
Published: January 2020

AbstractTo investigate how long non-coding RNAs DUXAP8 (LncRNA DUXAP8) influence the cell proliferation and invasion of non-small-cell lung cancer (NSCLC), we detected the expression levels of LncRNA DUXAP8 in lung cancer (LC) tissues, 4 LC-related cell lines (A549, SPC-A1, SK-MES-1 and NCI-H1299) and normal lung tissues via quantitative real-time PCR (qRT-PCR). Compared with normal lung tissue, LncRNA DUXAP8 was significantly up-regulated in NSCLC, especially in stage III / IV and diameter ≥ 3cm of lung cancer. Among 4 lung cancer cell lines, LncRNA DUXAP8 in A549 cells was the highest (P<0.001). Construction of LncRNA DUXAP8 overexpression and LncRNA DUXAP8 knockout in A549 cell lines was further performed and subsequently injected into nude mice to build an in vivo tumor xenograft model. The results indicated that LncRNA DUXAP8 overexpression significantly promoted the A549 cells’ proliferation, enhanced invasion and induced tumor growth. Conversely, LncRNA DUXAP8 knockout significantly suppressed A549 cells’ proliferation, weakened invasion and inhibited tumor growth. Taken together, our results imply that LncRNA DUXAP8 is a potential regulatory molecular marker in non-small-cell lung cancer.
Photophysical and antibacterial activity of light-activated quaternary eosin Y
Authors: Staneva Desislava , Yordanova Stanislava , Vasileva-Tonkova Evgenia , Stoyanov Stanimir , Grabchev Ivo 
Published: January 2020

AbstractThe functional characteristics of a new eosin dye with biocidal quaternary ammonium group (E) were studied in aqueous solution and in organic solvents of different polarity. The spectral properties depend on the nature and polarity of the respective solvents. The antimicrobial activity of compound E has been tested in vitro against Gram-negative bacteria (Escherichia coli, Acinetobacter johnsoni and Pseudomonas aeruginosa), Gram-positive bacteria (Sarcina lutea and Bacillus cereus) and the antifungal activity was tested against the yeasts Candida lipolytica in solution and after treated on cotton fabric. Broth dilution test has been used for quantitative evaluation of the antimicrobial activity of compound E against the model strains. The ability of compound E to inhibit the growth of model Gram-negative P. aeruginosa strain was assessed after 16 h of incubation in presence and absence of light. These experiments were conducted in planktonic format in solution and on cotton fabric. The results suggest that the new compound is effective in treating the relevant pathogens with better results being obtained by irradiation with light. In this case the quaternary ammonium group promotes the binding of eosin Y moiety to the bacterial cell wall thus accelerating bacterial photo inactivation.
The role of a chemical loop in removal of hazardous contaminants from coke oven wastewater during its treatment
Authors: Kwiecińska-Mydlak Anna , Sajdak Marcin , Rychlewska Katarzyna , Figa Jan 
Published: January 2020

AbstractCoke oven liquor is one of the most contaminated liquid streams generated by the coal processing industry, thus its proper treatment and utilization is crucial for sustainable and environmentally neutral plant operation. The conventional wastewater treatment process comprises of chemical and biological processes. Within the current research the detailed role of chemical treatment is described. Commercially available iron-based coagulants (PIX100, PIX100COP, PIX113, PIX116) were tested to understand their removal efficiency and impact on the stream parameters. The influence of iron dose in the range of 300-500 mgFe/L on the process performance was also examined.It was found that the main role of chemical treatment was to bind toxicants harmful to activated sludge microorganisms, i.e. free and complex cyanides and sulphides. Among the tested iron-based conventional coagulants ferrous salts were more efficient than ferric salts. It was also observed that efficiency of the process strongly depended on wastewater properties (especially in regard to pH, which should be in the range of 9-10) and the coagulant selection needed to be done individually for a given wastewater type. The removal rates of particular contaminants were diversified and for free cyanides, complex cyanides and sulphides they were in the range of 23-91%, -156-77% and -357-98%, respectively. The expected, simultaneous removal of chemical oxygen demand (COD) during the treatment was not observed and even the parameter value increased after the process due to probable formation of compounds less vulnerable to oxidation.
Characterization of non-compact locally compact groups by cocompact subgroups
Authors: Kadri Bilel 
Published: January 2020

Abstract
A subgroup H of a topological group G is called cocompact (or uniform) if the quotient space

G
/

H
¯

{G/\overline{H}}

is compact, where

H
¯

{\overline{H}}

denotes the closure of H in G.
The purpose of this paper is to give a characterization of non-compact locally compact groups with the property that every non-trivial closed (respectively, open) subgroup is cocompact (respectively, has finite index).
INS/gravity gradient aided navigation based on gravitation field particle filter
Authors: Liu Fanming , Li Fangming , Jing Xin 
Published: December 2019

Abstract
Swarm intelligence method is an effective way to improve the particle degradation and sample depletion of the traditional particle filter. This paper proposes a particle filer based on the gravitation field algorithm (GF-PF), and the gravitation field algorithm is introduced into the resampling process to improve particle degradation and sample depletion. The gravitation field algorithm simulates the solar nebular disk model, and introduces the virtual central attractive force and virtual rotation repulsion force between particles. The particles are moves rapidly to the high-likelihood region under action of the virtual central attractive force. The virtual rotation repulsion force makes the particles keep a certain distance from each other. These operations improve estimation performance, avoid overlapping of particles and maintain the diversity of particles. The proposed method is applied into INS/gravity gradient aided navigation, by combining the sea experimental data of an inertial navigation system. Compared with the particle swarm optimization particle filter(PSO-PF) and artificial physics optimized particle filter (APO-PF), the GF-PF has higher position estimate accuracy and faster convergence speed with the same experimental conditions.
Rechtsterroristische Gewalt in den 1970er Jahren
Authors: Manthe Barbara 
Published: January 2020

Vorspann
1979 standen zum ersten Mal in der Geschichte der Bundesrepublik Neonazis vor Gericht, denen terroristische Aktivitäten vorgeworfen wurden. Sie hatten in Norddeutschland eine Untergrundgruppe, die Kühnen-Schulte-Wegener-Gruppe, gebildet. Über diesen Fall ist, wie über den bundesdeutschen Rechtsterrorismus vor 1990 generell, bislang nur wenig bekannt. Barbara Manthe beleuchtet den Entstehungskontext und die Taten der Gruppe, die Raub- und Banküberfälle beging und politische Attentate plante. Zudem analysiert sie den Gerichtsprozess gegen die Täter in Bückeburg (Niedersachsen). Welchen Einfluss hatte der Sicherheitsdiskurs der 1970er Jahre auf die Verhandlung, die von den Verantwortlichen ausdrücklich Terroristenprozess präsentiert wurde? Waren die Angeklagten darin erfolgreich, mit Propaganda und Provokation vor Gericht ihre eigene terrorist show zu inszenieren?
A New Type of Aerostatic Thrust Bearing Controlled by High-speed Pneumatic Valve and a Novel Pressure Transducer
Authors: Rehman Waheed Ur , Jiang Guiyun , Wang Yongqin , Iqbal Nadeem , Ur Rehman Shafiq , Bibi Shamsa , Elahi Hassan 
Published: December 2019

The current research work presents a low cost, efficient and innovative active aerostatic thrust bearing which is controlled through a combination of the Arduino board, feedback transducers and high-speed valves. The purpose is to make low cost, compact active aerostatic thrust bearing with overall small dimensions and compact size. A prototype design is done in solid works with small dimensions and components are produced with the help of the high precision machining process. There are two high-speed electropneumatic valves which are controlled through pulse width modulation techniques. These high-speed electro-pneumatic valves modify the supply pressure of aerostatic bearing to achieve desired air height gap. There are two novel pressure sensors which provide a feedback signal for control. The test bench to perform experiments has been explained. The performance of the proposed aerostatic bearing is checked both in open loop and closed loop configuration with respect to static and dynamic conditions.
Pustulosis exantemática generalizada aguda inducida por meropenem
Authors: Coras Natalia , Pulido Alfredo , Rodríguez Cindy 
Published: December 2019

Presentamos el caso de una paciente mujer de 91 años, hospitalizada por infección de herida operatoria secundaria a cirugía de cadera. Se administró tratamiento antibiótico con meropenem, presentando a los 4 días: fiebre, astenia y una erupción eritematosa diseminada con pústulas no foliculares a predominio de tronco, extremidades y áreas de pliegues; además, se observó leucocitosis con neutrofilia. Al estudio histopatológico de biopsia de piel, se evidenciaron pústulas subcorneales con exocitosis de neutrófilos. Se suspendió antibiótico, con mejoría clínica a los 5 días posteriores de la suspensión de meropenem. Existen pocos reportes de casos de pustulosis exantemática generalizada aguda producido por meropenem.
Prácticas y conocimientos sobre prevención primaria de tuberculosis en estudiantes universitarios de ciencias de la salud en la región Tacna, Perú
Authors: Quispe-Prieto Silvia , Caipa-Ramos Manuel , Salas-Hallasi Solange , Salvador-Oré Karen , Romani Franco 
Published: December 2019

Introducción. La tuberculosis (TB) es un riesgo laboral para los trabajadores y estudiantes de salud. Objetivo. Describir las prácticas y conocimientos sobre prevención primaria de TB en estudiantes de ciencias de la salud, e identificar los factores asociados a las prácticas de prevención. Métodos. Estudio transversal en estudiantes del penúltimo año de cuatro universidades de Tacna. En 2018, aplicamos un cuestionario de 16 preguntas sobre conocimientos y 13 sobre prácticas de prevención en TB. Realizamos un análisis descriptivo para prácticas y conocimientos, además los factores asociados al puntaje de prácticas fueron determinados con un análisis de regresión lineal. Resultados. Participaron 264 estudiantes. 60,3% refiere que siempre usa el respirador N95 cuando interactúa con pacientes con TB. La carrera universitaria (β: -1,23, IC95%: -1,98 a -0,48) y el antecedente de prácticas en servicios de emergencia (β: 3,08, IC95%: 0,618 a 5,541) estuvieron asociados a prácticas de prevención. Conclusión. Existe una importante brecha en los conocimientos y prácticas sobre prevención primaria en TB en estudiantes antes de ingresar al internado.
Online resources and software for teaching and learning Latin
Authors: Balalaieva Olena 
Published: January 2020

ABSTRACT: The aim of this article is to review electronic resources in Latin, analyzing their didactic potential to help Classical teachers to effectively organize the educational process, diversifying the set of tools, and enhancing their work. Today, most of the useful links are accumulated on domestic professional sites devoted to the study of Latin. Many foreign scientists and teachers simply do not know about their existence. From time to time, attempts are made to summarize information and provide content for studying Classic languages in scientific publications, but such information quickly becomes outdated and needs to be regularly updated. This article provides an overview of the current most popular resources on Latin: digital libraries and databases, online courses, electronic textbooks, dictionary, translators etc.; describing the current state of the development of e-learning tools and websites for the study of Latin in Ukraine.
KEYWORDS: electronic educational resources; online resources; language learning; Latin language.

RESUMO: O objetivo do artigo é revisar recursos eletrônicos em Latim, analisando seu potencial didático para ajudar os professores clássicos a organizar efetivamente o processo educacional, diversificando o conjunto de ferramentas e aprimorando o seu trabalho. Hoje, a maioria dos links úteis é acumulada em vários sites domésticos dedicados ao estudo do Latim. Muitos cientistas e professores estrangeiros simplesmente não sabem sobre sua existência. De tempos em tempos, são feitas tentativas de resumir informações e fornecer conteúdo para o estudo de línguas clássicas em publicações científicas, mas essas informações rapidamente ficam desatualizadas e precisam ser atualizadas regularmente. Este artigo fornece uma visão geral dos recursos mais populares da atualidade em Latim: bibliotecas digitais e bancos de dados, cursos online, livros eletrônicos, dicionário, tradutores etc.; descreve o estado atual de desenvolvimento das ferramentas de e-learning e sites para o estudo do Latim na Ucrânia.
PALAVRAS-CHAVE: recursos educacionais eletrônicos; recursos online; aprendizagem de línguas; língua latina.
The moral dilemmas of Italian principals
Authors: Mortari Luigina , Tomba Barbara 
Published: January 2020

The purpose of this study is to investigate the moral dilemmas faced by a principal. A well-functioning school depends on many factors. Among these factors, the competence of the principal plays an important role. Often this competence, defined as leadership, is understood in a technical way because it is often interpreted as the acquisition of legal and management skills. In contrast, a good school requires strong humanistic competence and, in particular, ethical knowledge. The narratives of the principals reveal the sense of the inadequacy of their role: the administrators declared that they do not have a suitable and complete preparation to manage the complexity of the system. Their primary concerns relate to the evaluation and disciplinary aspects of the students, as well as the sense of responsibility aimed at the training of the entire person, not only his personal education.
Keywords: Ethical leadership, Italian principals, moral dilemmas.
Trombocitopenia Grave Induzida por Fenofibrato
Authors: Clara Ana , Martins Tiago , Martins Alexandra , Baptista Ana , Lázaro Mário 
Published: January 2020

A trombocitopenia induzida por fármacos é uma entidade frequente na prática clínica. No entanto, pela sua gravidade torna-se imperativo distinguir a trombocitopenia não-imune das formas imunomediadas potenci-almente ameaçadoras da vida. Os autores descrevem o caso clínico raro de um homem de 79 anos que se apresentou com púrpura trombocitopénica grave não-trombótica e gengivorragia ao sexto dia de introdu-ção diária de fenofibrato na sua medicação habitual. Foi feita exclusão do fármaco e administrada metilprednisolona 125 mg endovenoso durante três dias com resolução completa do quadro estabelecendo uma probabilidade elevada de diagnóstico. A trombocitopenia associada ao fármaco é reportada pelos fabricantes como um evento extremamente raro. Este é o segundo caso reportado de trombocitopenia imune ao fenofibrato, tendo o primeiro caso sido publicado em 2015.
HİLAFETTEN İSLAM DEVLETİNE ÇAĞDAŞ İSLAM SİYASİ DÜŞÜNCESİNİN ANA İSTİKAMETLERİ VE PROBLEMLERİ
Authors: KARA İsmail 
Published: January 2020

Çağdaş İslam siyasi düşüncesi hilafet-saltanat sisteminden
meşrutiyete, cumhuriyete, İslam devletine, oradan İslam
demokrasisine, İslam radikalizmine doğru hareket eden,
bu hareket sırasında klasik İslam siyasi düşüncesinin ana
kavramlarını yeniden üreten, yeni bir sıralamaya tâbi tutan,
bu arada Batıda ortaya çıkan yeni siyasi kavramları ve gelişmeleri
bile isteye yahut mecburiyetler karşısında takip edip
kendi kültürel şartlarının içine çekmeye çalışan bir düşünce
ve uygulama süreçlerinin toplamına işaret eder. Devlet
telakkisinde, din-siyaset ve yönetici-yönetilen ilişkilerinde,
siyasi kültürde meydana gelen değişmeler de bu süreçlerin
bir parçasıdır.
İçeriye ve dışarıya dönük olarak hem muhalefet ve tenkit
hem de uyum ve katılım kanallarını birlikte çalıştırmak ve
buralardan aktüel değeri ve uygulanabilirliği de olan bir çözüm
üretmek arzusunda ve iddiasında olan bu düşünce ve tartışmalar aynı zamanda bugünkü İslam dünyasının siyaset
alanındaki kuvvet ve zaaflarını, devamlılık ve farklılaşmalarını
içinde barındırması bakımından da önem taşıyor.
Bu çalışma Osmanlı/Türkiye tecrübesi merkezli olarak birbuçuk-
iki asırlık bir tecrübeyi siyasi düşünce, siyasi kurumlar
ve siyaset üslubu üzerinden ele almakta ve değerlendirmektedir.
A National Survey of Orthopaedic Residents Identifies Deficiencies in the Understanding of Medical Statistics
Authors: Araoye Ibukunoluwa , He Jun Kit , Gilchrist Scott , Stubbs Trevor , McGwin Gerald , Ponce Brent A. ,   on behalf of the Collaborative Orthopaedic Educational Research Group
Published: December 2019

Background:
Biomedical research is essential for optimizing patient care. Research has suggested inadequacies in nonorthopaedic trainees’ understanding of study design and biostatistics. This study assesses orthopaedic residents’ knowledge of common biostatistical and study design concepts, as well as their confidence in utilizing the medical literature.

Methods:
A validated survey assessing knowledge and the application of study design concepts was administered to residents at 10 U.S. institutions. The survey tested knowledge as well as confidence and attitudes regarding common biostatistics principles. The association of demographic characteristics, work activities, and confidence and attitude ratings with test performance were examined using t tests and analysis of variance.

Results:
The survey response rate was 64% (178 of 279). The largest group of participants were men (83%, 137 of 165), were between the ages of 26 and 30 years (59%, 105 of 177), and had graduated medical school within the past 4 to 10 years (43%, 76 of 175). Fifty-three percent (93 of 176) had prior biostatistics training, while 44% (77 of 176) had prior epidemiology training. Less than 5% of biostatistics or epidemiology training had taken place after medical school. Forty-seven percent (83 of 176) were unable to determine a study’s design. Thirty-eight percent (67 of 178) could not apply the concept of specificity and sensitivity. Eighty-three percent (147 of 178) could not assess the strength of a relationship using odds ratios. Sixty-nine percent (123 of 178) understood the implications of p values. Previous biostatistics training, but not epidemiology or evidence-based medicine training; inclusion of reading research, attending conferences, and data analysis; as well as a self-reported finding of statistics as important for the analysis of one’s own research data were significantly associated with better test performance (p < 0.05).

Conclusions:
Notable deficits exist in orthopaedic residents’ biostatistical knowledge. Greater emphasis is needed to improve biostatistics and research design training. The impact of biostatistics knowledge and/or aptitude on clinical decision-making is an area of suggested research.
Healing the Index Humeral Shaft Nonunion
Authors: Wiss Donald A. , Garlich John M. 
Published: December 2019

Background:
Humeral shaft nonunions are challenging to treat, and those that require >1 surgical procedure in order for a nonunion to heal are termed recalcitrant. Most studies on nonunion have evaluated the union rate independent of the number of procedures required to achieve union. The aims of the present study were (1) to compare the healing rates after the index operation for the treatment of a nonunion with conventional versus locked plating with or without graft augmentation, (2) to report the prevalence of recalcitrant nonunion, and (3) to identify risk factors that predict a recalcitrant nonunion.

Methods:
We performed a retrospective analysis of a prospectively collected database of 125 humeral shaft nonunions treated with open reduction and plate fixation by a single surgeon over 25 years. Univariate and multivariate regression analyses were performed to compare healing rates by type of plate fixation and biological augmentation and to identify demographic, injury, and treatment-related risk factors for the development of a recalcitrant nonunion.

Results:
One hundred and five patients (84%) had healing after the index procedure for the treatment of nonunion. Twenty patients (16.0%) required secondary procedures and were defined as having a recalcitrant nonunion. Eight of these patients (6.4% of the overall group) healed after the secondary interventions, and 12 (9.6% of the overall group) had a failure to unite. There were no significant differences in healing rates between conventional and locked plates or between the types of bone graft (autogenous or recombinant human bone morphogenetic protein). Risk factors for the development of a recalcitrant nonunion were plate fixation of the acute humeral fracture, a history of deep infection, and ≥2 prior procedures.

Conclusions:
Plate fixation with bone graft augmentation remains a successful method for the treatment of humeral shaft nonunions. Neither plate type nor graft type reduced the risk of a recalcitrant nonunion. Factors that predicted a recalcitrant nonunion were operative fixation of the acute fracture with a plate, a history of deep infection, and ≥2 surgical procedures.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Wpływ objawów choroby na jakość życia osób ze stwardnieniem rozsianym*
Authors: Jeżuchowska Alicja 
Published: January 2020

ABSTRACTIntroduction: Multiple sclerosis is a chronic autoimmune disease, usually occurring between 20 and 40 years of age, where central nervous system demyelination occurs.Materials and methods: After establishing cooperation with 5 departments of the Polish Society of Multiple Sclerosis in Poland and the Rehabilitation Center in Krakow, 179 questionnaires were obtained from people with multiple sclerosis. The study used diagnostic survey methods and standardized Quality of Life Questionnaire Short Form 36.Results: The largest group were women, 72.63%, the average disease duration was 13.18 years, the lowest quality of life values were the domain of social functioning 3.23 ±2.0 points, pain sensation 4.44 ±2.7 points and limitations resulting from the emotional state 8.02 ±6.8 points. A statistically significant correlation was found between age, sex, duration of the disease (p < 0.05) in selected domains and dimensions. The results of the analysis showed statistically significant correlations between the symptoms of the disease and the quality of life assessment in individual categories and dimensions (p < 0.05).Conclusions: 1. Assessment of the quality of life by patients with multiple sclerosis in particular domains is very diverse, with the lowest ranked domain concerning social contacts, the highest domain physical functioning and physical dimension. 2. Elderly people and those who have been suffering from multiple sclerosis for longer have rated their quality of life worse than younger and shorter suffering people. This applies mainly to the domain of physical functioning and the physical dimension. This is probably due to the disease process and adaptation to the changing conditions dictated by the progressive disease. 3. The severity of disease symptoms in people with multiple sclerosis is associated with a decrease in the quality of life of these people.