bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
Authors: Liu Delong 
Published: November 2019

AbstractNew advances in the design and manufacture of monoclonal antibodies, bispecific T cell engagers, and antibody-drug conjugates make the antibody-directed agents more powerful with less toxicities. Small molecule inhibitors are routinely used now as oral targeted agents for multiple cancers. The discoveries of PD1 and PD-L1 as negative immune checkpoints for T cells have led to the revolution of modern cancer immunotherapy. Multiple agents targeting PD1, PD-L1, or CTLA-4 are widely applied as immune checkpoint inhibitors (ICIs) which alleviate the suppression of immune regulatory machineries and lead to immunoablation of once highly refractory cancers such as stage IV lung cancer. Tisagenlecleucel and axicabtagene ciloleucel are the two approved CD19-targeted chimeric antigen receptor (CAR) T cell products. Several CAR-T cell platforms targeting B cell maturation antigen (BCMA) are under active clinical trials for refractory and/or relapsed multiple myeloma. Still more targets such as CLL-1, EGFR, NKG2D and mesothelin are being directed in CAR-T cell trials for leukemia and solid tumors. Increasing numbers of novel agents are being studied to target cancer-intrinsic oncogenic pathways as well as immune checkpoints. One such an example is targeting CD47 on macrophages which represents a “do-not-eat-me” immune checkpoint. Fueling the current excitement of cancer medicine includes also TCR- T cells, TCR-like antibodies, cancer vaccines and oncolytic viruses.
Prevalence of intestinal parasitic infection and associated factors among pregnant women attending antenatal care at public health facilities in Lalo Kile district, Oromia, Western Ethiopia
Authors: Yesuf Dejene Abraham , Abdissa Lensa Tesfaye , Gerbi Emiru Adeba , Tola Edosa Kifle 
Published: November 2019

Abstract

Objective
This study aimed to assess the prevalence of intestinal parasitic infection and associated factors among pregnant women attending antenatal care at public health facilities in Lalo Kile district, Oromia, Western Ethiopia.

Results
Out of the 315 respondents, the mean age was 24.7 ± 2.54 years ranging between 15 and 44 years. The majority of the respondents were Oromo in ethnicity (90.2%) and protestant in religion (83.2%) and almost all (99%) of the study participants were married. Two hundred twenty-six (72%) of pregnant women were attended at least primary school and two hundred forty-six (78.1%) of the respondents were from farmer households. About half of the households (51.7%) had a monthly income of greater than 35 USD. The overall prevalence of intestinal parasitic infection was 138 (43.8%) with the predominance of hookworm (33.7%) followed by Ascaris lumbricoides (7.3%). Being a farmer [AOR, 95% CI 7.3 (1.46, 37.00), P = 0.03], walking barefooted [AOR, 95% CI 6.13 (1.98, 19.00), P = 0.002] and absence of proper handwashing after latrine [AOR, 95% CI 5.36 (1.78, 16.00), P = 0.003] were significantly associated with occurrence of the intestinal parasitic infection.
FoxB, a new and highly conserved key factor in arthropod dorsal–ventral (DV) limb patterning
Authors: Heingård Miriam , Turetzek Natascha , Prpic Nikola-Michael , Janssen Ralf 
Published: November 2019

AbstractForkhead box (Fox) transcription factors evolved early in animal evolution and represent important components of conserved gene regulatory networks (GRNs) during animal development. Most of the researches concerning Fox genes, however, are on vertebrates and only a relatively low number of studies investigate Fox gene function in invertebrates. In addition to this shortcoming, the focus of attention is often restricted to a few well-characterized Fox genes such asFoxA(forkhead),FoxC(crocodile) andFoxQ2. Although arthropods represent the largest and most diverse animal group, most other Fox genes have not been investigated in detail, not even in the arthropod model speciesDrosophila melanogaster. In a general gene expression pattern screen for panarthropod Fox genes including the red flour beetleTribolium castaneum, the pill millipedeGlomeris marginata, the common house spiderParasteatoda tepidariorum, and the velvet wormEuperipatoides kanangrensis, we identified a Fox gene with a highly conserved expression pattern along the ventral ectoderm of arthropod and onychophoran limbs. Functional investigation ofFoxBinParasteatodareveals a hitherto unrecognized important function of FoxB upstream ofwingless(wg) anddecapentaplegic(dpp) in the GRN orchestrating dorsal–ventral limb patterning.
Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
Authors: Franco-Bocanegra Diana K. , George Bethany , Lau Laurie C. , Holmes Clive , Nicoll James A. R. , Boche Delphine 
Published: November 2019

AbstractMicroglial function is highly dependent on cell motility, with baseline motility required for homeostatic surveillance activity and directed motility to migrate towards a source of injury. Experimental evidence suggests impaired microglial motility in Alzheimer’s disease (AD) and therefore we have investigated whether the expression of proteins associated with motility is altered in AD and affected by the Aβ immunotherapy usingpost-mortembrain tissue of 32 controls, 44 AD cases, and 16 AD cases from our unique group of patients immunised against Aβ42 (iAD).Sections of brain were immunolabelled and quantified for (i) the motility-related microglial proteins Iba1, cofilin 1 (CFL1), coronin-1a (CORO1A) and P2RY12, and (ii) pan-Aβ, Aβ42 and phosphorylated tau (ptau). The neuroinflammatory environment was characterised using Meso Scale Discovery multiplex assays. The expression of all four motility-related proteins was unmodified in AD compared with controls, whereas Iba1 and P2RY12, the homeostatic markers, were increased in the iAD group compared with AD. Iba1 and P2RY12 showed significant positive correlations with Aβ in controls but not in the AD or iAD groups. Pro- and anti-inflammatory proteins were increased in AD, whereas immunotherapy appears to result in a slightly less pro-inflammatory environment.Our findings suggest that as Aβ appears during the ageing process, the homeostatic Iba1 and P2RY12 –positive microglia respond to Aβ, but this response is absent in AD. Aβ-immunisation promoted increased Iba1 and P2RY12 expression, likely reflecting increased baseline microglial motility but without restoring the profile observed in controls.
Modeling and control of planar slippage in object manipulation using robotic soft fingers
Authors: Fakhari Amin , Kao Imin , Keshmiri Mehdi 
Published: November 2019

Abstract
Slippage occurrence has an important roll in stable and robust object grasping and manipulation. However, in majority of prior research on soft finger manipulation, presence of the slippage between fingers and objects has been ignored. In this paper which is a continuation of our prior work, a revised and more general method for dynamic modeling of planar slippage is presented using the concept of friction limit surface. Friction limit surface is utilized to relate contact sliding motions to contact frictional force and moment in a planar contact. In this method, different states of planar contact are replaced with a second-order differential equation. As an example of the proposed method application, dynamic modeling and slippage analysis of object manipulation on a horizontal plane using a three-link soft finger is studied. Then, a controller is designed to reduce and remove the undesired slippage which occurs between the soft finger and object and simultaneously move the object on a predefined desired path. Numerical simulations reveal the acceptable performance of the proposed method and the designed controller.
A detection metric designed for O’Connell effect eclipsing binaries
Authors: Johnston Kyle B. , Haber Rana , Caballero-Nieves Saida M. , Peter Adrian M. , Petit Véronique , Knote Matt 
Published: November 2019

AbstractWe present the construction of a novel time-domain signature extraction methodology and the development of a supporting supervised pattern detection algorithm. We focus on the targeted identification of eclipsing binaries that demonstrate a feature known as the O’Connell effect. Our proposed methodology maps stellar variable observations to a new representation known as distribution fields (DFs). Given this novel representation, we develop a metric learning technique directly on the DF space that is capable of specifically identifying our stars of interest. The metric is tuned on a set of labeled eclipsing binary data from the Kepler survey, targeting particular systems exhibiting the O’Connell effect. The result is a conservative selection of 124 potential targets of interest out of the Villanova Eclipsing Binary Catalog. Our framework demonstrates favorable performance on Kepler eclipsing binary data, taking a crucial step in preparing the way for large-scale data volumes from next-generation telescopes such as LSST and SKA.
Predictors of undernutrition among the elderly in Sodo zuriya district Wolaita zone, Ethiopia
Authors: Wondiye Kidest , Asseffa Netsanet Abera , Gemebo Tsegaye Demisse , Astawesegn Feleke Hailemichael 
Published: November 2019

AbstractBackgroundIn any society, the elderly are among the vulnerable and high risk groups with regard to health status. In persons over the age of 60 years, nutrition is among the important determinants of health. However, undernutrition among the elderly is often under diagnosed and/or neglected. Hence, in this study, we looked at prevalence and factors associated with undernutrition among the elderly.MethodsA community based cross-sectional study was conducted at Sodo Zuriya district. Multi-stage systematic sampling method was used to select 578 elderly. A structured questionnaire was used to collect data on socio-demographics, dietary diversity, and health status of the elderly.Measurements of weight and height were taken using digital weighing scale and stadio-meter, respectively. Data was entered and cleaned in Epi-Data version3.1and exported to SPSS version 20 for analysis. Binary and multivariate logistic regressions were done and odds ratios with 95% confidence intervals were calculated.ResultsThe overall prevalence of undernutrition was 17.1%. On multivariate logistic regression, being unable to read and write (AOR = 2.09), not being married (AOR = 2.02), history of decline in food intake (AOR = 2.1), smoking (AOR = 4.9) and monthly income <$20 (AOR = 7.5) were factors positively associated with undernutrition.ConclusionThe study revealed that prevalence of undernutrition in the district was relatively high. Hence, it is among the major public health burdens in the district. Hence, to improve nutritional status of elderly the district health office and health professionals should consider behavioral support interventions to assist in cessation of smoking. There is also a need to financially empower the elderly in the district.
Changes in oncogenic protein levels in peri-implant oral malignancy: a case report
Authors: Seo Mi Hyun , Myoung Hoon , Lee Jong Ho , Kim Soung Min , Lee Suk Keun 
Published: November 2019

Abstract

Background
Oral squamous cell carcinoma (OSCC) constitutes a group of tumors that exhibit heterogeneous biology, histopathology, and clinical behaviors.

Case presentation
A 73-year-old male had a whitish leukoplakia-like lesion around inflamed peri-implant area (#42, #43, and #44), and this lesion had transformed to OSCC within 3 years. He underwent mass resection, selective neck dissection, and reconstructive surgery. To detect any carcinogenesis progression, we examined the removed tumor tissue as well as the patient’s preoperative and postoperative sera to identify causative oncogenic proteins using immunoprecipitation high-performance liquid chromatography (IP-HPLC).

Conclusions
The protein expression levels of p53, E-cadherin, β-catenin, MMP-10, HER2, NRAS, Met, HER2, and ERb were significantly lower in the serum collected on postoperative day 10 than in the preoperative serum, and if these proteins are consistently not elevated in the serum 3 months after surgery compared with the preoperative serum, these proteins can be potential oncogenic proteins. However, we also found that the serum extracted 3 months after the operation had elevated levels of oncogenic proteins compared with that of the preoperative and 10-day postoperative serum indicating the possibility of tumor recurrence. At postoperative follow-up period, ipsilateral neck metastasis and second primary lesion were found and additional surgery was performed to the patient. IP-HPLC using the patient’s serum shows the possibility of oncogenic protein detection. However, follow-up IP-HPLC data is needed to find out patient-specific prognostic factors.
Application of 2D full-waveform inversion on exploration land data
Authors: Borisov Dmitry , Gao Fuchun , Williamson Paul , Tromp Jeroen 
Published: November 2019

Estimating subsurface seismic properties is an important topic in civil engineering, oil and gas exploration, and global seismology. We have developed an application of 2D elastic waveform inversion with an active-source on-shore data set, as is typically acquired in exploration seismology on land. The maximum offset is limited to 12 km, and the lowest available frequency is 5 Hz. In such a context, surface waves are generally treated as noise and are removed as a part of data processing. In contrast to the conventional approach, our workflow starts by inverting surface waves to constrain shallow parts of the shear wavespeed model. To mitigate cycle skipping, frequency- and offset-continuation approaches are used. To accurately take into account free-surface effects (and irregular topography), a spectral-element-based wave propagation solver is used for forward modeling. To reduce amplitude influences, a normalized crosscorrelation (NC) objective function is used in conjunction with systematic updates of the source wavelet during the inversion process. As the inversion proceeds, body waves are gradually incorporated in the process. At the final stage, surface and body waves are inverted together using the entire offset range over the band between 5 and 15 Hz. The inverted models include high-resolution features in the first 500 m of compressional and shear wavespeeds, with some model updates down to 4.0 km in the first parameter. The inversion results confirmed by well-log information, indicate a better fit of compressional to shear wavespeeds ratios compared with the initial model. The final data fit is also noticeably improved compared to the initial one. Although our results confirm previous studies demonstrating that an NC norm combined with a source time function correction can partly stabilize purely elastic inversions of viscoelastic data, we believe that including an attenuation depth model in the forward simulation gives better results.
Preliminary assessment of the utilization of durian peel liquid smoke as a natural preservative for mackerel
Authors: Faisal Muhammad , Gani Asri , Mulana Farid 
Published: November 2019

Background: Durian peel is a type of biomass waste that contains cellulose, hemicelluloses, and lignin. The pyrolysis of these compounds results in production of liquid smoke which can be used as a natural preservative to replace current synthetic preservatives. This research assessed the ability of liquid smoke produced during pyrolysis of durian peel to preserve fish. Methods: Dry durian peel waste underwent batch reactor pyrolysis at 340°C and 380°C, resulting in production of liquid smoke (grade 3), charcoal, and tar. This liquid smoke was then distilled at 190°C to produce grade 1 liquid smoke, which was used to preserve mackerel. The preservation process was conducted by soaking the mackerel samples in liquid smoke at 0.5, 1, 2, and 3% concentration levels followed by observations every 6 hours. Tests to determine the total volatile base nitrogen (TVB-N) content, antibacterial quality of the liquid smoke and organoleptic quality of the fish were conducted in order to assess the preservation properties of the liquid smoke. Results: Tests on the antibacterial effects showed that the liquid smoke inhibited the growth of Escherichia coli and Staphylococcus aureus on fish even at low concentrations. At 54 hours, the TVB-N values remained below 30 mg nitrogen/g, indicating that the fish was still safe for human consumption. Results from the organoleptic tests showed that the concentration of liquid smoke influenced the preservation effects. Conclusions: At a concentration of 2–3%, the fish samples possessed acceptable flavor, taste, color and texture for up to 48 hours of soaking. However, the best conditions were obtained with a 3% concentration of liquid smoke (produced with 340°C pyrolysis), as the fish was still considered acceptable for up to 42 hours.
Interventions to improve birth outcomes of pregnant women living in low- and middle-income countries: a systematic review and network meta-analysis
Authors: Park Jay J. H. , Harari Ofir , Siden Ellie , Zoratti Michael , Dron Louis , Zannat Noor-E , Lester Richard T. , Thorlund Kristian , Mills Edward J. 
Published: November 2019

Background:Improving the health of pregnant women is important to prevent adverse birth outcomes, such as preterm birth and low birthweight. We evaluated the comparative effectiveness of interventions under the domains of micronutrient, balanced energy protein, deworming, maternal education, and water sanitation and hygiene (WASH) for their effects on these adverse birth outcomes.Methods:For this network meta-analysis, we searched for randomized clinical trials (RCTs) of interventions provided to pregnant women in low- and middle-income countries (LMICs). We searched for reports published until September 17, 2019 and hand-searched bibliographies of existing reviews. We extracted data from eligible studies for study characteristics, interventions, participants’ characteristics at baseline, and birth outcomes. We compared effects on preterm birth (<37 gestational week), low birthweight (LBW; <2500 g), and birthweight (continuous) using studies conducted in LMICs.Results:Our network meta-analyses were based on 101 RCTs (132 papers) pertaining to 206,531 participants. Several micronutrients and balanced energy food supplement interventions demonstrated effectiveness over standard-of-care. For instance, versus standard-of-care, micronutrient supplements for pregnant women, such as iron and calcium, decreased risks of preterm birth (iron: RR=0.70, 95% credible interval [Crl] 0.47, 1.01; calcium: RR=0.76, 95%Crl 0.56, 0.99). Daily intake of 1500kcal of local food decreased the risks of preterm birth (RR=0.36, 95%Crl 0.16, 0.77) and LBW (RR=0.17, 95%Crl 0.09, 0.29), respectively when compared to standard-of-care. Educational and deworming interventions did not show improvements in birth outcomes, and no WASH intervention trials reported on these adverse birth outcomes.Conclusion:We found several pregnancy interventions that improve birth outcomes. However, most clinical trials have only evaluated interventions under a single domain (e.g. micronutrients) even though the causes of adverse birth outcomes are multi-faceted. There is a need to combine interventions that of different domains as packages and test for their effectiveness.Registration:PROSPEROCRD42018110446; registered on 17 October 2018.
Dual mobility in primary total hip arthroplasty: current concepts
Authors: Cuthbert Rory , Wong James , Mitchell Philip , Kumar Jaiswal Parag 
Published: November 2019

Total hip arthroplasty (THA) is one of the most successful surgical procedures – reducing pain and providing functional improvement. However, THA instability is a disabling condition and remains the most common indication for revision THA. To combat the risk of instability, the concept of dual mobility (DM) was developed. This article provides a comprehensive review of DM in the literature. Widespread use of first-generation DM was limited due to concern regarding wear of the polyethylene head and the unique complication of intraprosthetic dislocation (IPD). Implant modifications using highly cross-linked, durable polyethylene and a smooth, cylindrical femoral neck have all but eliminated IPD in contemporary DM. In multiple studies, DM demonstrates statistically significant reductions in dislocation rates comparative to standard bearing primary THA. These results have been particular promising in high-risk patient populations and femoral neck fractures – where low dislocation rates and improved functional outcomes are a recurrent theme. From an economic perspective, DM is equally exciting – with lower accrued costs and higher accrued utility comparative to standard bearing THA. Longer-term clinical evidence and higher-quality prospective comparative studies are required to strengthen current research. Dual mobility may well represent the future gold standard for THA in high-risk patient populations and femoral neck fractures, but due diligence of long-term performance is needed before recommendations for widespread use can be justified. Cite this article: EFORT Open Rev 2019;4:640-646. DOI: 10.1302/2058-5241.4.180089
On the affirmative solution to Salem’s problem
Authors: Yakubovich Semyon 
Published: November 2019

Abstract
The Salem problem to verify whether Fourier–Stieltjes coefficients of the Minkowski question mark function vanish at infinity is solved recently affirmatively. In this paper by using methods of classical analysis and special functions we solve a Salem-type problem about the behavior at infinity of a linear combination of the Fourier–Stieltjes transforms. Moreover, as a consequence of the Salem problem, some asymptotic relations at infinity for the Fourier–Stieltjes coefficients of a power

{m\in\mathbb{N}}

of the Minkowski question mark function are derived.
Optimal Design of Reliability Acceptance Sampling Plan Based on Sequential Order Statistics
Authors: Kumar Mahesh , Ramyamol P. C. 
Published: November 2019

Abstract
The concept of sequential order statistics were introduced by Kamps in 1995. In this article, we derive an acceptance sampling plan, for units having exponentially distributed lifetime, using sequential order statistics. Based on data obtained from progressive type II censoring using constant stress accelerated life tests, we obtain the maximum likelihood estimates of the parameters of the exponential distribution. Further, a log linear life-stress relationship is assumed to derive the exact distributions of the estimators of the parameters of exponential distribution. The parameters of the sampling scheme are obtained by minimizing expected total testing cost satisfying usual probability requirements. Some numerical results are presented in a table to illustrate our plans.