bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Recognition System for Tree Images based on Caffe Platform and Deep Learning
Authors: Li Zongchen , Zhang Wenzhuo , Zhou Guoxiong 
Published: August 2020

Abstract
Aiming at the difficult problem of complex extraction for tree image in the existing complex background, we took tree species as the research object and proposed a fast recognition system solution for tree image based on Caffe platform and deep learning. In the research of deep learning algorithm based on Caffe framework, the improved Dual-Task CNN model (DCNN) is applied to train the image extractor and classifier to accomplish the dual tasks of image cleaning and tree classification. In addition, when compared with the traditional classification methods represented by Support Vector Machine (SVM) and Single-Task CNN model, Dual-Task CNN model demonstrates its superiority in classification performance. Then, in order for further improvement to the recognition accuracy for similar species, Gabor kernel was introduced to extract the features of frequency domain for images in different scales and directions, so as to enhance the texture features of leaf images and improve the recognition effect. The improved model was tested on the data sets of similar species. As demonstrated by the results, the improved deep Gabor convolutional neural network (GCNN) is advantageous in tree recognition and similar tree classification when compared with the Dual-Task CNN classification method. Finally, the recognition results of trees can be displayed on the application graphical interface as well. In the application graphical interface designed based on Ubantu system, it is capable to perform such functions as quick reading of and search for picture files, snapshot, one-key recognition, one-key e
Indicator-Based Assessment of Coping and Adaptive Strategies Against Flood Hazards in Tal and Diara Regions of Malda District, West Bengal (India)
Authors: Rishi Hiranmay , Purkayastha Subrata 
Published: August 2020

Abstract
Malda district of West Bengal is extremely vulnerable to floods. Yet this district reports high density of population suggesting that the people here must have adopted coping and adaptive strategies to meet the flood menace which is almost an annual affair. This paper addresses and compares the preparedness, coping and adaptive strategies of the local people at household level living in two distinct physiographic units viz. Tal and Diara of Malda. Further, an attempt is made whether the distance from the river plays any role in the coping and adaptive strategy of the villagers. This paper is empirical in nature, primary data has been generated through field investigation in two sets of villages of Tal and Diara, conducted in the month of September and October 2018. Field data has been quantified and measured to assess the level of resilience of the people to flood hazard/disaster. UNDP technique has been used for developing preparedness, coping and adaptive indexes. The score ranges between 0 and 1, where higher the score higher is the level of resilience.
Image-Based Ultrasomics Classifiers: A Potential Method to Noninvasively Predict the Proliferation-Related Biomarker Ki67
Authors: yuan anna , Xu Guoze , Fang Guiting , Li Tong , Lai Xiaomin , Zhong Xing , Huang Furong 
Published: August 2020

Abstract
Objectives: The proliferation-related biomarker Ki67 is excellent in predicting the prognosis of breast cancer. 3D ultrasound imaging can provide information about coronal section images that help diagnose breast cancer. Our study aims to develop an ultrasomics method that extracts information related to Ki67 by analyzing the maximum transverse/sagittal/coronal section images of breast cancer mass. Methods: Our study retrospectively collected data on patients who had finished 3D ultrasound examinations and were pathologically diagnosed with breast cancer. Images met the criteria were segmented, and then regions of interest (ROIs) were outlined for extracting ultrasomics features, such as statistical, morphological, texture, filter, and wavelet features.Results: The least absolute shrinkage and selection operator (LASSO) regression model selected 16 features that were closely related to the Ki67. The classification results of sensitivity, specificity, accuracy, and area under curve (AUC) of the transverse-sectional images were 0.6451, 0.8064, 0.7258, and 0.8065 (95% CI, 0.6915-0.9214), respectively; for sagittal-sectional images were 0.5806, 0.7741, 0.6774, and 0.6660 (95% CI, 0.5283-0.8037) respectively; for coronal-sectional images were 0.5806, 0.6774, 0.6290, and 0.7159 (95% CI, 0.5847-0.8471) respectively, and for a combination of three-section images were 0.7667, 0.7500, 0.7580, and 0.8510 (95% CI, 0.7537 -0.9483).Conclusions: The model classifier based on the transverse section images performed better than that based on the sagittal/coronal section images. The model classifier based on a combination of three-section images had a better outcome than that used only single section images. Image-based ultrasomics classifiers can noninvasively predict the Ki67 of breast cancer.
CCT6A, a Novel Prognostic Biomarker for Ewing's Sarcoma
Authors: Jiang Jie , Liu Chong , Xu Guoyong , Liang Tuo , Yu Chaojie , Qin Zhaojie , Liao Shian , Xue Jiang , Zeng Haopeng , Zhang Zide , Lu Zhaojun , Wang Zequn , Chen Jiarui , Chen Tianyou , Li Hao , Zhan Xinli 
Published: August 2020

Abstract
Background: Ewing's sarcoma (ES) is the second most prevalent malignancy among bone tissue tumors, and there is no adequate prognosis biomarker. The protein encoded by CCT6A is a molecular chaperone. Early studies have suggested that CCT6A is involved in the development of many cancers, however, there is no clear evidence of a role for CCT6A in ES.Methods: In this study, we performed a bioinformatics analysis of 32 Ewing sarcoma specimens from the GSE17618 dataset for differences in gene expression and overall survival, event-free survival, and gene expression in different subgroups. Results: After three screenings, we identified CCT6A as highly correlated with Ewing's sarcoma prognosis. Survival analysis showed low overall survival (OS) for CCT6A high expression (P=0.024). On the other hand, Cox regression analysis showed that CCT6A expression, event-free survival (EFS), and age were strongly associated with the prognosis of Ewing sarcoma, identified as independent poor prognostic biomarkers. (CCT6A: P=0.015; Age: P-value=0.026; EFS: P-value=0.001). Conclusion: The expression level of CCT6A is strongly associated with the prognosis of Ewing's sarcoma. High expression of the CCT6A gene may serve as a biomarker for poor prognosis in patients with Ewing's sarcoma.
Parent-infant Closeness Increased by Close Collaboration With Parents Intervention - Before and After Study in Nine NICUs&nbsp;
Authors: He Felix , Axelin Anna , Ahlqvist-Björkroth Sari , Raiskila Simo , Löyttyniemi Eliisa , Lehtonen Liisa 
Published: August 2020

Abstract
Background Parent-infant closeness during neonatal hospital care brings many benefits for both infants and parents. We developed an educational intervention for neonatal staff, the Close Collaboration with Parents, to improve family-centered care during hospital care. The aim of this study was to evaluate the effectiveness of the intervention on parent-infant closeness in nine hospitals in Finland.MethodsParents of hospitalized infants were recruited in the hospitals during 3-month periods before and after the Close Collaboration with Parents intervention. The data were collected using daily Closeness diaries. Mothers and fathers separately filled in the time they spent in the hospital and the time of skin-to-skin contact (SSC) with their infant during each hospital care day until discharge. Statistical analyses were done using a linear model with covariates.ResultsDiaries were kept before and after the intervention by a total of 170 and 129 mothers and 126 and 84 fathers, respectively. From the infant perspective, either of his/her parent was present on average 453 minutes per day before the intervention and 620 minutes after the intervention in the neonatal unit. In the adjusted model, the increase was 99 minutes per day (p=0.0007). The infants were in SSC on average 76 minutes per day before the intervention and 114 minutes after the intervention. In the adjusted model, SSC increased 24 minutes per day (p=0.0405).ConclusionThe Close Collaboration with Parents intervention increased parents’ presence and SSC in nine hospitals. This study suggests that parent-infant closeness may be one mediating factors explaining benefits of parenting interventions.
Influence of Depression on Physical and Mental Health in Patients with Angina
Authors: Alharbi Raed 
Published: August 2020

Abstract
Purpose: Angina is well known as chest pain caused by insufficient flow of oxygen-rich blood to the cardiac muscle. Although there are several studies showing an association between depression and angina, none of these studies investigated the influence of depression on the physical and mental health of adult patients with angina, which is the overall goal of this study.Methods: This study used a publicly open data source from the Behavioral Risk Factor Surveillance System (BRFSS), 2017, in the United States. The BRFSS questionnaire relating to health, behaviors, and social life was administered to the United States residents through a telephone interview. There were 450,013 participants in this survey. Different statistical methods, including descriptive, inferential, and predictive methods, were conducted through the Statistical Analysis System (version 9.4) to accomplish the goal of this study. Results: Of the 450,013 participants in the BRFSS 2017, 25,389 were adult patients diagnosed with angina. Of these, 22,875 have depression. This study showed that depression had a statistically significant influence on physical and mental health in adult patients with angina.Conclusion: Depression has a significant influence on physical and mental health of adult patients with angina. Depression increased the physical health problems by 61.95% and mental health problems by 33.15% in adult patients with angina.
Long Non-Coding RNA FOXD1-AS1 Promotes the Progression and Glycolysis of Nasopharyngeal Carcinoma by Sustaining FOXD1 Expression
Authors: Wang Zhanwang , He Dong , Zhu Yuxing , Hu Xueying , Jin Yi , Gong Lian , Xiao Mengqing , Xiang Liang , Zeng Qinghai , Liu Jianye , Chen Xingyu , Zhang Yeyu , Cao Ke 
Published: August 2020

Abstract
Background: Increasing evidence have emphasized the importance of long non-coding RNAs (lncRNAs) in various human cancers progression. Forkhead box D1 antisense RNA1 (FOXD1-AS1) is a novel lncRNA and plays vital regulatory role in diverse biological processes of cancers. However, the biological function, molecular mechanism and clinical significance of FOXD1-AS1 in nasopharyngeal carcinoma is still unknown.Methods: Comprehensive bioinformatics analysis and qRT-PCR was conducted to detect the expression level of FOXD1-AS1. Loss-of-function and gain-of-function experiments were performed to verify the functions of FOXD1-AS1 in proliferation, migration, invasion, apoptosis and glycolysis of nasopharyngeal carcinoma in vitro and in vivo. Further bioinformatics analysis and experiments were carried out to explore the underlying molecular mechanisms of FOXD1-AS1. Results: FOXD1-AS1 was significantly overexpressed in nasopharyngeal carcinoma and associated with poor survival in patients. Knockdown of FOXD1-AS1 significantly inhibited cell proliferation, migration, invasion and glycolysis, and promotes apoptosis in nasopharyngeal carcinoma, whereas over-expression of FOXD1-AS1 has the opposite effect. Mechanistically, we found that FOXD1-AS1 could upregulate the expression of FOXD1 through stabilizing the FOXD1 expression at mRNA and protein levels, and FOXD1 increased the glycolysis level by transcriptionally upregulating the expression of LDHA, PKM and ENO1, thus playing an oncogenic role in nasopharyngeal carcinoma progression. Conclusion: FOXD1-AS1 plays a critical regulatory role in nasopharyngeal carcinoma. The identified FOXD1-AS1/FOXD1 axis may serve as a potential prognostic biomarker and therapeutic target for patients with nasopharyngeal carcinoma.
Synthesis and Application of Magnetic@Layered Double Hydroxide Multicore-Shell Nanostructure as a Novel Anti-Inflammatory Drugs Nanocarrier
Authors: Yousefi Vahid , Tarhriz Vahideh , Eyvazi Shirin , Dilmaghani Azita 
Published: August 2020

Abstract
Background: magnetic nanocomposites with a core-shell nanostructure has huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experimentand is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and in following, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as the anti-inflammatory drugs by using exchange anion experiment, the basal spacing of synthesized layered double hydroxides were compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs by bridging bidentate interaction. Besides, in vitro drug release experiments in pH 7.4, Phosphate-buffered saline (abbreviated PBS) showed the constant release profiles with Ibuprofen and diclofenac as model drugs with different lipophilicity and water solubility and size and steric effect. Conclusions: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity and high thermal stability. We confirm, which Fe3O4@LDH multicore-shell nanostructure will have potential application for constant drug delivery.
An Assessment of Band Keratopathy Depth With Anterior Segment Optical Coherence Tomography
Authors: Song Hee-Jun , Rand Gabriel M. , Chuck Roy S. , Kwon Ji-won 
Published: August 2020

Abstract
Background: To describe the anterior segment optical coherence tomography (AS-OCT) findings in a series of patients with band keratopathy (BK) and discuss its possible clinical utility. Methods: A retrospective review of 31 eyes from 31 consecutive patients with BK from November 2013 to October 2018. Lesion depth and central corneal thickness (CCT) were outputted from AS-OCT (RS-3000 Advance, NAVIS-EX 1.5.5 Nidek CO LTD, Japan). Results: There were 20 cases of ocular trauma, 3 cases of retinal detachment, 2 cases of glaucoma, 2 cases of uveitis, 1 case of Coats’ disease, 1 case of complicated cataract surgery, 1 case of non-clearing vitreous hemorrhage, and 1 case of unknown etiology. Mean duration of the opacity per patient history was 22.4±11.3 (range 3-40) years. 26 eyes were no light perception (NLP), 3 eyes were light perception (LP) and 2 eyes were hand motion (HM). The calcium band as seen on AS-OCT corresponded to a hyperflective layer with posterior shadowing. The median depth of calcium was 100 µm (range 55-320) and the median CCT was 623 µm (range 534-785). The calcium depth was strongly correlated with the duration of the opacity per patient history (r=0.68, p<0.001). Conclusions: AS-OCT may be utilized to assess BK depth. This depth has a wide distribution that is positively correlated with the duration of the opacity per patient history. Future studies will be required to measure BK depth across patients with less severe vision loss, test the consistency of AS-OCT measurements across different instruments, and confirm its clinical utility.
Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Etiology of Exfoliation Syndrome
Authors: Hirbo Jibril , Pasutto Francesca , Gamazon Eric , Evans Patrick , Pawar Priyanka , Berner Daniel , Sealock Julia , Tao Ran , Straub Peter , Konkashbaev Anuar , Breyer Max , Schlötzer-Schrehardt Ursula , Reis Andre , Brantley Milam , Khor Chiea Chuen , Joos Karen , Cox Nancy 
Published: August 2020

Abstract
Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common cause of secondary glaucoma, resulting in widespread global blindness. We performed Transcriptomic Wide Association Studies using PrediXcan models trained in 48 GTEx tissues to identify genetically-determined gene expression changes associated with XFS risk, leveraging on results from a global GWAS that included 123,457 individuals from 24 countries. Twenty-eight genes in the chr15q22-25 region showed statistically significant associations in both single-tissue and multi-tissue analysis. Reduced models for these genes that excluded variants in LD with the known LOXL1 signal showed genome-wide significant association signals in nine genes, independently of LOXL1. Out of these ten genes, mRNA transcript levels for ARID3B, CD276, LOXL1, NEO1, SCAMP2, and UBL7 were significantly decreased in iris tissues from XFS patients compared to control samples. Genes with genetically determined expression changes in XFS were significantly enriched for genes associated with inflammatory conditions. We further explored the health consequences of high susceptibility to XFS using a large electronic health record and observed a higher incidence of XFS comorbidity with inflammatory and connective tissue diseases. Our results implicate a role for connective tissues and inflammation in the etiology of XFS. Targeting the inflammatory pathway may be a potential therapeutic option to reduce progression in XFS.
The Meridian-like High Thermal Line as the Evidence on Existence of Meridians in Human Body
Authors: cha yongchol , choe hyok , oh songjin , cha zinhwa , dong zhang 
Published: August 2020

Abstract
Background; The acupuncture meridian is the channel through which Qi & Blood flow, and acupuncture is having many thousands year history for treating various illnesses. However, there was no powerful evidence to prove the existence of meridians until now. Objectives; The purpose of this study is to explain that the meridian-like high thermal line (MLHTL) is the powerful evidence to prove the existence of meridians in human body. Methods; The meridian-like high thermal line inducing and the disease cure effect in the target organs connected along the meridians by the mineral pulse light stimuli, was researched and analyzed. Results; The meridian-like high thermal lines were induced along the classic meridians course at the human body surface, and simultaneously the internal refractory diseases such as nephrotic syndrome and angina pectoris were treated in the target organs connected along the meridians without drug use by the mineral pulse light stimuli. Conclusions; The meridian-like high thermal line is the powerful evidence to prove the existence of meridians in human body. From now on, MPL stimulator (Version 1) can induce MLHTL, and can show the non-drug cure effect in target organ connected along MLHTL.
Graphene Oxide Nanofilm and Chicken Embryo Extract Decrease the Invasiveness of HepG2 Liver Cancer Cells.
Authors: Sosnowska Malwina , Kutwin Marta , Strojny Barbara , Koczoń Piotr , Szczepaniak Jarosław , Bałaban Jaśmina , Daniluk Karolina , Jaworski Sławomir , Chwalibog André , Bielawski Wiesław , Sawosz Ewa 
Published: August 2020

Abstract
Background: The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompanied by a disruption of the physicochemical properties of the ECM which deregulates the cell-ECM interaction and can lead to uncontrolled proliferation and neoplastic transformation of cells. Therefore, it can be assumed that ECM modification and restoration of its characteristics for healthy tissue may counteract uncontrolled cell proliferation. The purpose of the presented research model was to optimise the physical characteristics of ECM by introducing a graphene oxide plane/nanofilm (nfGO) and enriching the cell environment with potentially missing proteins by adding a functional protein cocktail (chicken embryo liver extract) and determine the impact of these factors on cell-ECM cooperation and its consequences on adhesion, proliferation, and cell phase, which are factors of the invasiveness of cancer cells.Results: Experiments were performed with non-cancer HS-5 cells and liver cancer cells HepG2 and C3A. The cells were divided into four groups; (1) control, (2) cultured on GO nanofilm, (3) cultured with the addition of chicken embryo liver extract (CELE) to the medium and (4) cultured on the GO nanofilm with the addition of CELE. CELE contained 1735 proteins; the top 57 of these proteins have been presented. The use of GO nanofilm as well as CELE and nfGO + CELE reduced the proliferation of HepG2 cancer cells to the greatest extent; this is in contrast to non-cancer cells and also to C3A cancer cells. Furthermore, the combined use of the CELE protein cocktail and GO substrate effectively resulted in a decrease in the population of HepG2 cells in the G0/G1 phase and an increase of the population in G2/M. Molecular analysis of HepG2 cancer cells also showed an increase in the expression of genes responsible for adhesion such as fak (focal adhesion kinase), e-cadherin, and n-cadherin and a decrease in β-catenin, which is considered a proto-oncogen. Conclusions: Studies have shown that both the GO surface structure on which the cells are grown as well as the presence of a multi-component natural cocktail of regulatory proteins, can modify the expression of integrins, increase adhesion and, as a consequence, proliferation and the cell cycle - entering the resting phase. For the first time, it has been documented that hepatic cancer cells of the HepG2 line under the influence of stimuli derived from mimic ECM (graphene oxide) in interaction with a unique protein complex derived from chicken liver embryo decreased of the invasiveness of cancer cells.