bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Ordination of Religious in the Kuyavian Diocese in the First Half of the Sixteenth Century
Authors: Kaczmarek Krzysztof 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 62 (2014), issue 2.
The presented work makes reference to results of research on the ordination of religious clergy by bishops of the dioceses of Gniezno and Płock in the 15th and 16th centuries. The analysis of the contents of the books of pontifical acts of the Kuyavian bishops issued in the first half of the 16th century and the survey of selected books of the Włocławek Consistory permits the identification of more than 100 previously unknown members of the religious clergy originating chiefly from monasteries situated in the area of the Kuyavian Diocese, who received minor or major holy orders from their ordinaries and suffragans.
The Incarnate Logos in Gnostic Theology
Authors: Myszor Wincenty 
Published: October 2019

The Polish version of the article was published in “Roczniki Humanistyczne,” vol. 58–59 (2010–2011), issue 3.
The popular version of Gnostic Christology in textbooks presents it as a Docetic Christology. The new texts by Christian Gnostics, uncovered in Nag Hammadi, prove that Gnostic Christology was first and foremost the Christology of the Church. It seems thus that Adolf Harnack’s term “the doctrine of two natures” describing the Gnostic approach is correct. The article quotes examples of Gnostic utterances from Tractatus Tripartitus of Nag Hammadi Codex I. Gnostic theology was close to Logos-centred Christology. The Gnostic statements also contain many other references to ecclesiastical theology. The author of Tractatus Tripartitus was clearly influenced by Church theology, but some ideas were later abandoned by the official doctrine of the Church.
Between Non-Fiction and the Literature of the Personal Document: Remarks on the Structure of Gustaw Herling-Grudziński’s Podróż to Burmy (A Journey To Burma)
Authors: Panas Paweł 
Published: October 2019

The Polish version of the article was published in Roczniki Humanistyczne vol. 57, issue 1 (2009).
This text describes the literary structure (the immanent poetics) of Gustaw Herling-Grudziński’s 1952 diary Podróż do Burmy (A Journey to Burma) to properly situate this work in the domain of non-fiction and to indicate the most important characteristics of the writer’s diarist conception.
The Church’s Temporal Goods in the Work and the Final Document Drafted by the First Synod of the Diocese of Opole
Authors: Szymański Andrzej 
Published: October 2019

In the article, a reflection is made on the legal regulations developed by the First Synod of the Diocese of Opole, concerning the management of temporal goods of the Diocese. The study presents the content of 17 statutes and 5 annexes (as well as considering earlier studies produced by one of the synodal working commissions, intended to be discussed by the parish synodal groups), and reflects on the completeness of the legal treatment of this vital yet complex area of ecclesiastical life. The solutions adopted by the Synod should be considered incomplete, but the synodal legislator, that is the diocesan bishop, has the right to enact such particular norms as he deems appropriate and necessary.
The use of ridge regression for estimating the severity of acute pancreatitis
Authors: Cherdantsev D. V. , Stroev A. V. , Mangalova E. S. , Kononova N. V. , Chubarova O. V. 
Published: October 2019

Purpose. Increasing of treatment efficiency for patients with acute pancreatitis by improving objective means of determining the severity of acute pancreatitis.Materials and method. The study was based on a retrospective analysis of 130 cases of acute pancreatitis: 47 cases from «Krasnoyarsk Regional Clinical Hospital» and 83 cases from «Regional Interdistrict Clinical Hospital No 20 named after I.S. Berzon» in the period from 2015 to 2017. The raw data was pre-processed. In particular, different methods (median, linear regression) were used to fill the missing values in the observation matrix. The initial dataset contained features measured in various quantitative and categorical scales. For some features with a pronounced asymmetric distribution, a quantile transformation was applied to initial values. The quantile transformation allows features to be brought to a uniform distribution in order to reduce the risk of excluding significant features. Ridge regression was used in combination with an algorithm for sequential reduction of attribute space.Results. The classifier of three degrees of acute pancreatitis severity was developed. This classifier can help to determine better treatment tactics. During validation, the method of determining the severity of acute pancreatitis classification has proven to be effective. The average accuracy was 92% compared to the experts’ decisions. This procedure for constructing a classifier can be used as part of the basis to the medical decision support system.Conclusion. The results of this study will help to make the choice of a necessary starting therapy, assess the need for surgical intervention and in severe cases, prescribe enhanced antibacterial and detoxification therapy. This will predictably reduce the percentage of septic complications of acute pancreatitis, and consequently will reduce the frequency of fatal outcomes.
Effect of DNA methylation modulators on the production of osteoprotegerin by rheumatoid fibroblast-like synoviocytes in vitro: their migration and invasion
Authors: Shnayder M. A. , Shirinsky V. S. , Kalinovskaya N. Y. , Shirinsky I. V. 
Published: October 2019

Objective. The purpose of the research was to study the effect of DNA methylation modulators on the production of proinflammatory cytokines by fibroblast-like synovial cells (FLC).Materials and methods. We used the cells derived from the synovial tissue of 6 patients with active rheumatoid arthritis (RA) after 3–7 in vitro culturing passages.Results. There was an IL-1β-induced up-regulation of osteoprotegerin (OPG) synthesis in the RA FLC cultures. The addition of methylating compounds S-Adenosyl methionine (SAMe) and genistein into the cultures resulted in a statistically significant decrease in the production of OPG, while the addition of the demethylating agent hydralazine did not change the synthesis of the cytokine. All three DNA methylation modulators used at different concentrations significantly reduced the percentage of spontaneous migration and invasion of FLC in the Boyden chamber.Conclusion. Enzymes and molecular complexes involved in DNA methylation could be potential therapeutic targets, and in vitro FLC cultures of RA patients can be used as a model for preclinical screening of new drug compounds.
On the necessity of a single approach to written medical expert conclusions
Authors: Evteeva I. A. , Shigeev S. V. 
Published: October 2019

The aim of the study was to study the available approaches to the formulation and quality control of forensic medical expert conclusions. We have studied the literature sources containing recommendations on drawing up expert opinions and improving their quality. After a selection of scientific publications and publications on the subject matter with the help of a descriptive method, the article presents the existing approaches to this problem. As a result of the conducted research, the absence of any general objective requirements for expert conclusions was revealed. The development of unified standards for writing and the definition of “signs of quality” of expert conclusions is a promising task of forensic science and practice, the solution of which will improve the quality of examinations.
Complications and relapses after alloplasty of large and giant hernia of the esophageal aperture of the diaphragm
Authors: Rosenfeld I. I. 
Published: October 2019

The review of the literature presents the content analysis of surgical treatment of large and giant hernia of the esophageal aperture of the diaphragm as well as the analyses of complications when using the main methods of hernioplasty. Alloplasty of the esophageal aperture of the diaphragm remains a large and unresolved surgical problem, as evidenced by the analyzed literature sources, mainly reviews and clinical recommendations.Firstly, alloplasty can cause postoperative complications with a frequency of up to 20%, especially when using rigid polypropylene and composite polytetrafluoroethylene mesh implants with circular paraesophageal fixation. Modern biological nets now show high incidence of anatomical relapses, so most specialists continue to use synthetic implants, of which the most promising ones are lightweight, mesh, partially absorbable structures.Secondly, clear indications for alloplasty have not been developed, for example, according to the size of the hernia of the esophageal opening in the diaphragm, which is the main risk factor for relapses.Thirdly, it is still not clear what indicator should be used to estimate the size of hernia of the esophageal aperture of the diaphragm and, therefore, it is not clearly defined which hernias are considered small, which are large and which are giant, despite the fact that the three terms constantly appear in the medical literature.Fourthly, the optimal technique for alloplasty has not been determined with large and especially giant hernias, which would prevent anatomical relapses, and at the same time would not cause postoperative complications.It is necessary to outline the following ways to solve these problems: to develop effective and at the same time safe methods of alloplasty of large and giant hernias; to determine clear indications for alloplasty of the esophageal opening of the diaphragm, depending on the size of hernias; to create an appropriate, applied classification of hernias of the esophageal aperture of the diaphragm.
Studying the adaptogenic activity of a series of tetrahydropyrido[2,1-b] [1,3,5] thiadiazine derivatives
Authors: Bibik E. Yu. , Nekrasa I. A. , Demenko A. V. , Frolov K. A. , Dotsenko V. V. , Krivokolysko S. G. 
Published: October 2019

Introduction. In the modern world people are exposed to the influence of adverse psychological and physical factors, escalating in intensity. The search for new pharmacodynamic effects of [1,3,5]-thiadiazine derivatives designated by significant biological activity of these compounds is an essential issue.Aim. To research adaptogenic activity of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives using a modified Porsolt Forced Swim Test.Materials and methods. Four substances from the group of 3-R-8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6Hpyrido[2,1-b][1,3,5]thiadiazine-9-carbonitriles were selected for the research. Rats were divided into a control group, 5 reference groups (amitriptyline, caffeine, thiotriazolin, thiocetam, ginseng) and 4 experimental groups according to the number of the studied original tetrahydropyrido[2,1-b][1,3,5] thiadiazine derivatives.Results. Intragastric injection of substance 2 for 5 days in the modified forced swim test (forced swimming with freight) increased work capacity and endurance of the rats by 103.42% as opposed to the initial results. The detected adaptogenic activity of this tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivative six times exceeds adaptogenic activity of ginseng and seven times that of amitriptyline. The rats in the control group were active for a bit longer time. Ginseng raised the time of activity by 17% at day 5. Caffeine essentially reduced work capacity and endurance. Amitriptyline showed adaptogenic activity at day 3 of the research (increase by 10.4%). Thiotriazolin also showed adaptogenic activity on day 3 of the research (increase by 30.17%). Thiocetam increased the time of activity by 78.55%. Substance 4 had adaptogenic activity too; it increased the time of activity in aversive conditions by 58.25%, which three times exceeds this parameter for ginseng and four times for amitriptyline.
Development of a method for preparing octreotide derivative for diagnosis of neuroendocrine tumors
Authors: Larkina M. S. , Podrezova E. V. , Bragina O. D. , Tagirova E. A. , Chernov V. I. , Yusubov M. S. , Nesterov E. A. , Skuridin V. S. , Krivoshchekov S. V. , Yanovskaya E. A. , Gurto R. V. , Belousov M. V. 
Published: October 2019

Currently the development of technologies for labeling somatostatin with technetium-99m for diagnosing radionuclide neuroendocrine tumors is under way. Somatostatin analogues are binded with technetium99m only by the preliminary addition of a chelating agent. Therefore, it is important to develop a method for preparation of an octreotide derivative by modifying octreotide with precursors: ligands with high chelating ability for its tight binding with technetium-99m. ω-Bis(pyridin-2-ylmethyl)amino)aliphatic acids can be used successfully as such precursors.The purpose of the study was to develop a method for obtaining a new octreotide derivative for diagnosing neuroendocrine tumors.Materials and methods. The somatostatin octreotide analogue was used as the object of the study; succinimid-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used as a chelating agent. Methods of high performance liquid chromatography and mass spectrometry were used to separate and analyze the synthesized compounds.Results. A method to produce an original octreotide derivative using a succinimid-1-yl 6-(bis(pyridin2-ylmethyl)amino)hexanoate as a chelating agent was proposed. The conditions of analytical and semipreparative HPLC for the analysis and purification of the active octreotide derivative (a monosubstituted derivative of the amino acid residue of D-phenylalanine) were suggested.Conclusion. The synthesized derivative of octreotide has a chelating center for strong binding to technetium-99m in its structure, which can be useful for diagnosing neuroendocrine tumors.
Level of aurathrenomedullin in chronic heart failure of ischemic genesis: associations with clinical manifestations
Authors: Myasoedova E. I. 
Published: October 2019

Objective.To identify and evaluate the relationship between the level of proadrenomedullin and clinical and anamnestic data of patients with chronic heart failure of ischemic genesis.Materials and methods. 240 men with chronic forms of coronary heart disease (mean age 55.9 [43; 63] years) and past Q-forming myocardial infarction were examined. Of these, 110 patients had chronic heart failure and preserved left ventricular ejection fraction (group 1) and 130 patients had chronic heart failure and dilatation with a low left ventricular ejection fraction (group 2). In all patients the MR-proADM level in the blood serum was determined.Results. In the control group, the level of MR-proADM was 0.49 [0.18; 0.58] nmol /l. In the meantime, it was statistically significantly higher in the studied groups of patients than in the control group (p < 0.001 and p < 0.001, respectively). And in the group of patients with chronic heart failure and dilatation with a low left ventricular ejection fraction, it was statistically significantly higher than in the group of patients with chronic heart failure and preserved left ventricular ejection fraction (1.72 [1.56; 1.98] nmol/l and 0.89 [0.51; 1.35] nmol/l, respectively, p < 0.038). The study demonstrated the presence of statistically significant associations between the level of MR-proADM and the severity of chronic heart failure and exertional angina pectoris as well as between the presence of a constant form of atrial fibrillation and the levels of systolic and diastolic blood pressure.Conclusion. MR-proADM is a new promising marker, which will be possible to use as a diagnostic standard for assessing the effectiveness of treatment of cardiac patients.
The items in the Chinese version of the Montreal Cognitive Assessment Basic discriminate among different severities of Alzheimer’s disease
Authors: Zhang Yan-rong , Ding Yun-Long , Chen Ke-liang , Liu Yan , Wei Can , Zhai Ting-ting , Wang Wen-Juan , Dong Wan-Li 
Published: October 2019

Abstract
Background

To determine whether items of the Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) could discriminate among cognitively normal controls (NC), and those with mild cognitive impairment (MCI), mild Alzheimer’s disease (AD), and moderate-severe (AD), as well as their sensitivity and specificity.Methods

MCI (n=456), mild AD (n=502) and moderate-severe AD (n=102) patients were recruited from the memory clinic, Huashan Hospital, Shanghai, China. NC (n=329) were recruited from health checkup outpatients. Five MoCA-BC item scores were collected in interviews.Results

The MoCA-BC orientation test had high sensitivity and specificity for discrimination among MCI, mild AD and moderate-severe AD. The delayed recall memory test had high sensitivity and specificity for MCI screening. The verbal fluency test was efficient for detecting MCI and differentiating AD severity.Conclusions

Various items of the MoCA-BC can identify MCI patients early and identify the severity of dementia.
Determinants of effective organisational capacity training: lessons from a training programme on health workforce development with participants from three African Countries
Authors: Amde Woldekidan Kifle , Marchal Bruno , Sanders David , Lehmann Uta 
Published: October 2019

Abstract
Background
Health systems in sub-Saharan Africa face multifaceted capacity challenges to fulfil their mandates of service provision and governance of their resources. Four academic institutions in Africa implemented a World Health Organisation-funded collaborative project encompassing training, curriculum development, and partnership to strengthen national leadership and training capacity for health workforce development. This paper looks into the training component of the project, a blended Masters programme in public health that sought to improve the capacity of personnel involved in teaching or management/development of human resources for health. The paper aims to explore factors influencing contribution of training to organisational capacity development.

Methods
We chose a case study design. Semi-structured interviews were held with 18 trainees that were enrolled in the training programme, and who were affiliated to health ministries or public health training institutions. We gathered additional data through document reviews, observation, and interviews with 14 key informants associated with the programme and/or working in the collaborating institutions. The evidence gathered were analysed thematically.

Results
Thirteen of the eighteen training participants stayed in the target institutions and contributed to improved capacity of their institutions in the fields of management, policy, planning, research, training, or curriculum development. Five left for private and international agencies due to dissatisfaction with payment, work conditions, or career prospect.

Factors that were associated with the training, trainees, and the institutional and broader context, determine contribution of training to organisational capacity development. These include relevance of newly acquired knowledge and skills set of trainees to the role/position they assume in the organisation; recognition of trainees by employing organisations in terms of promotion or assignment of challenging tasks; and motivation and retention of trained staff.

Conclusion
Training, even if relevant and applicable, makes no more than a ‘latent’ contribution, one which is activated and realised through alignment of clusters of interacting contextual and relational factors related to the target institutions and trained personnel. While not predictable, implementers need to focus more deliberately on the likely interaction and best possible alignments between training relevance, student selection for potential to contribute, recognition and career advancement potential.
Laryngeal mask versus endotracheal intubation for pre-hospital emergency airway management: a meta-analysis of randomized control studies
Authors: Li Hao , Duan Ming-da , Zhang Yun-liang , You Shao-hua , Song Yu-xiang , Zhang Xuan , Liu Min , Liu Wen-gang , Hou Ai-sheng , cao jiangbei 
Published: October 2019

Abstract
Background : Pre-hospital emergency airway management plays an important role in pre-hospital care. Laryngeal masks are increasingly employed for the airway management of pre-hospital critical patients and have achieved promising results. Although several randomized controlled trials have reported benefits, the efficacy of laryngeal masks in pre-hospital emergency airway management compared to endotracheal intubation have not been systematically reviewed.
Methods: Electronic databases (PubMed, Cochrane Library, Embase, Scopus and CNKI) were searched up to April 2019 for related randomized studies. Outcome indicators included overall intubation success rates, the success rates of the first intubation, insertion time, ventilation efficiency rates, SpO2 rise time, the blood gas index and adverse events. Two investigators selected the trials, extracted the data according to inclusion and exclusion criteria, and assessed the quality of the literature according to the Jada score. The meta-analysis was performed using stata14.0 software.
Results: We included 31 human studies. Compared to endotracheal intubation, the application of laryngeal mask for pre-hospital emergencies enhanced the ventilation efficiency rates [RR=1.20, 95% CI (1.06, 1.35), P<0.001], improved the success of first intubation [RR=1.29, 95% CI (1.18, 1.40), P<0.001] and the patients’ blood gas index, shortened the insertion and SpO2 rise times [SMD=-3.48, 95% CI (-4.17, -2.80), P < 0.001; -2.19, 95% CI (-3.06, -1.32), P < 0.001] and reduced the incidence of adverse events [RR=0.41, 95% CI (0.30, 0.57, P<0.001]. All results were stable and statistically significant.
Conclusions: Laryngeal masks could quickly and effectively improve patient ventilation in pre-hospital emergencies, highlighting its utility for clinical application.