bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles
Authors: Bahadur Gulam , Homburg Roy , Bosmans Judith E , Huirne Judith A F , Hinstridge Peter , Jayaprakasan Kanna , Racich Paul , Alam Rakib , Karapanos Ioannis , Illahibuccus Afeeza , Al-Habib Ansam , Jauniaux Eric 
Published: March 2020

ObjectiveTo compare success rates, associated risks and cost-effectiveness between intrauterine insemination (IUI) and in vitro fertilisation (IVF).DesignRetrospective observational study.SettingThe UK from 2012 to 2016.ParticipantsData from Human Fertilisation and Embryology Authority’s freedom of information request for 2012–2016 for IVF/ICSI (intracytoplasmic sperm injection)and IUI as practiced in 319 105 IVF/ICSI and 30 669 IUI cycles. Direct-cost calculations for maternal and neonatal expenditure per live birth (LB) was constructed using the cost of multiple birth model, with inflation-adjusted Bank of England index-linked data. A second direct-cost analysis evaluating the incremental cost-effective ratio (ICER) was modelled using the 2016 national mean (baseline) IVF and IUI success rates.Outcome measuresLB, risks from IVF and IUI, and costs to gain 1 LB.ResultsThis largest comprehensive analysis integrating success, risks and costs at a national level shows IUI is safer and more cost-effective than IVF treatment.IVF LB/cycle success was significantly better than IUI at 26.96% versus 11.49% (p<0.001) but the IUI success is much closer to IVF at 2.35:1, than previously considered. IVF remains a significant source of multiple gestation pregnancy (MGP) compared with IUI (RR (Relative Risk): 1.45 (1.31 to 1.60), p<0.001) as was the rate of twins (RR: 1.58, p<0.001).In 2016, IVF maternal and neonatal cost was £115 082 017 compared with £2 940 196 for IUI and this MGP-related perinatal cost is absorbed by the National Health Services. At baseline tariffs and success rates IUI was £42 558 cheaper than IVF to deliver 1LB with enhanced benefits with small improvements in IUI. Reliable levels of IVF-related MGP, OHSS (ovarian hyperstimulation syndrome), fetal reductions and terminations are revealed.ConclusionIUI success rates are much closer to IVF than previously reported, more cost-effective in delivering 1 LB, and associated with lower risk of complications for maternal and neonatal complications. It is prudent to offer IUI before IVF nationally.
Ca2Si5N8:Eu2+ phosphors synthesized in graphite crucibles for enhanced reducing atmosphere
Authors: Hsiao Chih-Wei , Oi Mitsuo , Shibai Koki , Murai Kei-Ichiro , Moriga Toshihiro , Shih Shao-Ju 
Published: March 2020

We easily synthesized a pure calcium silicon nitride phosphor powder, Ca2Si5N8:Eu[Formula: see text] from starting materials stable in air, using a graphite crucible to provide reducing conditions at a comparatively lower calcination temperature (1400[Formula: see text]C) and shorter reaction time (8 h) under an atmospheric pressure. At 150[Formula: see text]C, the nitride phosphor still retained 77% of its original emission intensity at room temperature.
Effect of HCl+LiF Etching Process on Electrochemical Performance of Ti3C2
Authors: Huang Yuhua , Li Weiwei , Mei Bingchu , Yang Yu , Liu Zuodong 
Published: March 2020

In this paper, the effects of etching temperature and concentrations of hydrochloric acid (HCl) on the exfoliating process and the electrochemical performance of LIBs were systematically explored. The transformation from Ti3AlC2 to Ti3C2 was analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and Raman spectra. The suitable conditions of preparing Ti3C2 MXene though HCl and lithium fluoride (LiF) were obtained. Besides, the in-situ oxidation conditions of Ti3C2 during the etching process were studied. The TiO2/Ti3C2 was beneficial to improve the specific capacity from 125[Formula: see text]mAh[Formula: see text]g[Formula: see text] to 150[Formula: see text]mAh[Formula: see text]g[Formula: see text] at 1 C.
A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation
Authors: Chiu Danica , Tavaré Richard , Haber Lauric , Aina Olulanu H. , Vazzana Kristin , Ram Priyanka , Danton Makenzie , Finney Jennifer , Jalal Sumreen , Krueger Pamela , Giurleo Jason T. , Ma Dangshe , Smith Eric , Thurston Gavin , Kirshner Jessica R. , Crawford Alison 
Published: March 2020

Abstract

Patients with hematologic cancers have improved outcomes after treatment with bispecific antibodies that bind to CD3 on T cells and that redirect T cells toward cancer cells. However, clinical benefit against solid tumors remains to be shown. We made a bispecific antibody that targets both the common prostate tumor–specific antigen PSMA and CD3 (PMSAxCD3) and provide evidence for tumor inhibition in several preclinical solid tumor models. Mice expressing the human extracellular regions of CD3 and PSMA were generated to examine antitumor efficacy in the presence of an intact immune system and PSMA expression in normal tissues. PSMAxCD3 accumulated in PSMA-expressing tissues and tumors as detected by immuno-PET imaging. Although PSMAxCD3 induced T-cell activation and showed antitumor efficacy in mice with low tumor burden, PSMAxCD3 lost efficacy against larger solid tumors, mirroring the difficulty of treating solid tumors in the clinic. Costimulatory receptors can enhance T-cell responses. We show here that costimulation can enhance the antitumor efficacy of PSMAxCD3. In particular, 4-1BB stimulation in combination with PSMAxCD3 enhanced T-cell activation and proliferation, boosted efficacy against larger tumors, and induced T-cell memory, leading to durable antitumor responses. The combination of CD3 bispecific antibodies and anti-4-1BB costimulation represents a therapeutic approach for the treatment of solid tumors.
Identification of the Targets of T-cell Receptor Therapeutic Agents and Cells by Use of a High-Throughput Genetic Platform
Authors: Gejman Ron S. , Jones Heather F. , Klatt Martin G. , Chang Aaron Y. , Oh Claire Y. , Chandran Smita S. , Korontsvit Tatiana , Zakahleva Viktoriya , Dao Tao , Klebanoff Christopher A. , Scheinberg David A. 
Published: March 2020

AbstractT-cell receptor (TCR)–based therapeutic cells and agents have emerged as a new class of effective cancer therapies. These therapies work on cells that express intracellular cancer-associated proteins by targeting peptides displayed on MHC receptors. However, cross-reactivities of these agents to off-target cells and tissues have resulted in serious, sometimes fatal, adverse events. We have developed a high-throughput genetic platform (termed “PresentER”) that encodes MHC-I peptide minigenes for functional immunologic assays and determines the reactivities of TCR-like therapeutic agents against large libraries of MHC-I ligands. In this article, we demonstrated that PresentER could be used to identify the on-and-off targets of T cells and TCR-mimic (TCRm) antibodies using in vitro coculture assays or binding assays. We found dozens of MHC-I ligands that were cross-reactive with two TCRm antibodies and two native TCRs and that were not easily predictable by other methods.
Two new genera of Desmiphorini (Coleoptera, Cerambycidae, Lamiinae) with description of a species with non-retractile parameres
Authors: Nascimento Francisco Eriberto De Lima , Santos-Silva Antonio 
Published: March 2020

In this study, two new genera of Desmiphorini (Lamiinae) are proposed: Cleidaria gen. nov., to include Cleidaria cleidae sp. nov. from the state of Chiapas in Mexico, and Obscenoides gen. nov. for Desmiphora (D.) compta Martins & Galileo, 2005. The shape of tarsal claws of Cleidaria cleidae sp. nov. (abruptly narrowed from basal half) is so far, not found in any current genera of the tribe. With respect to Obscenoides compta (Martins & Galileo, 2005) comb. nov., the genitalia of males have an unusual shape with non-retractile parameres. The character combination related to this genital structure is unknown to us in other species in the family, and hypotheses about its function are suggested.
Erratum: Elaphidiini (Coleoptera, Cerambycidae) from the Caribbean region of Colombia: New species, taxonomic notes and new geographical records
Authors: García Kimberly , Nascimento Francisco Eriberto De Lima 
Published: March 2020

Two new species of Elaphidiini from Colombia are described: Sphaerion costae sp. nov., and Mephritus costae sp. nov. The keys to species of Sphaerion Audinet-Serville, 1834 and Mephritus Pascoe, 1866 are translated and modified to include the new species. Chromatic variations of Mephritus apicatus (Linsley, 1935) are reported. Moreover, the geographical distribution is expanded for 12 species of Elaphidiini.
Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore: an unrecognised public health issue?
Authors: Chan Wui Ling , Dargan Paul Ivor , Haynes Colleen Michelle , Green Jody Lynn , Black Joshua Curtis , Dart Richard Charles , Wood David Michael 
Published: March 2020

Introduction:
Misuse of prescription medicines and the harms associated with such use are growing threats across the world. There is currently, however, limited data on the extent of prescription medicine misuse in Singapore and whether this is a current threat in the country.

Methods:
An online survey, limited to 1,000 individuals (aged 21 years and over) who were residents in Singapore, was administered through a survey panel company in September 2015. The survey collected information on participant demographics, and their awareness, self-reported lifetime and past-year misuse of commonly available prescription medicines in Singapore as well as the use of a range of recreational drugs and novel psychoactive substances (NPS).

Results:
Lifetime (6.7%) and past-year (4.8%) misuse of any prescription medicine was comparable to lifetime (6.0%) and past-year (3.0%) use of any recreational drugs/NPS. The top five prescription medicines for lifetime misuse were: diazepam (2.7%); codeine (2.3%); dhasedyl (promethazine, codeine and ephedrine; 1.6%); panadeine (paracetamol and codeine; 1.5%); and methylphenidate (1.2%). The top five drugs for past-year misuse were: diazepam (1.6%); codeine (0.9%); panadeine (0.7%); alprazolam (0.6%); baclofen (0.6%); and gabapentin (0.6%).

Conclusion:
Misuse of prescription medicine in Singapore was common, with prevalence comparable to the use of recreational drugs/NPS. A common source for misused drugs was physicians. Further studies are required to determine whether this is more widespread in Singapore and establish the different forms of drug diversion, so that appropriate prevention strategies can be implemented.
<p><strong><em>Phaeosphaeriopsis omaniana </em></strong><strong>(Phaeosphaeriaceae, Pleosporales), a novel fungus from Oman</strong></p>
Authors: AL-JARADI ASMA J. , MAHARACHCHIKUMBURA SAJEEWA S. N. , AL-SADI ABDULLAH M. 
Published: March 2020

A fungus within the genus Phaeosphaeriaceae was isolated from brown leaf spot samples of Dracaena serrulata Baker (Yemen dragon tree) collected from Oman Botanic Garden, Muscat, Oman. Detailed morphological studies showed that this strain fits well within the species concept of the genus Phaeosphaeriopsis. Multilocus phylogeny based on LSU, ITS and TEF confirmed its uniqueness and supports its recognition as a new species, Phaeosphaeriopsis omaniana. Geography, pathogenic life mode and subglobose, smooth and brown conidia of the newly described species clearly differ from those of phylogenetically related species. A comprehensive description and illustrations of the new species, P. omaniana is provided and discussed with comparable taxa.
Potential Vorticity and Balanced and Unbalanced Moisture
Authors: Wetzel Alfredo N. , Smith Leslie M. , Stechmann Samuel N. , Martin Jonathan E. , Zhang Yeyu 
Published: March 2020

AbstractAtmospheric flows are often decomposed into balanced (low frequency) and unbalanced (high frequency) components. For a dry atmosphere, it is known that a single mode, the potential vorticity (PV), is enough to describe the balanced flow and determine its evolution. For a moist atmosphere with phase changes, on the other hand, balanced–unbalanced decompositions involve additional complexity. In this paper, we illustrate that additional balanced modes, beyond PV, arise from the moisture. To support and motivate the discussion, we consider balanced–unbalanced decompositions arising from a simplified Boussinesq numerical simulation and a hemispheric-sized channel simulation using the Weather Research and Forecasting (WRF) Model. One important role of the balanced moist modes is in the inversion principle that is used to recover the moist balanced flow: rather than traditional PV inversion that involves only the PV variable, it is PV-and-Minversion that is needed, involvingMvariables that describe the moist balanced modes. In examples of PV-and-Minversion, we show that one can decompose all significant atmospheric variables, including total water or water vapor, into balanced (vortical mode) and unbalanced (inertio-gravity wave) components. The moist inversion, thus, extends the traditional dry PV inversion to allow for moisture and phase changes. In addition, we illustrate that the moist balanced modes are essentially conserved quantities of the flow, and they act qualitatively as additional PV-like modes of the system that track balanced moisture.
Relations between Interannual Variability of Regional-Scale Indonesian Precipitation and Large-Scale Climate Modes during 1960–2007
Authors: Alsepan Givo , Minobe Shoshiro 
Published: March 2020

AbstractRegional-scale precipitation responses over Indonesia to major climate modes in the tropical Indo–Pacific Oceans, namely canonical El Niño, El Niño Modoki, and the Indian Ocean dipole (IOD), and how the responses are related to large-scale moisture convergences are investigated. The precipitation responses, analyzed using a high-spatial-resolution (0.5° × 0.5°) terrestrial precipitation dataset for the period 1960–2007, exhibit differences between the dry (July–September) and wet (November–April) seasons. Canonical El Niño strongly reduces precipitation in central to eastern Indonesia from the dry season to the early wet season and northern Indonesia in the wet season. El Niño Modoki also reduces precipitation in central to eastern Indonesia during the dry season, but conversely increases precipitation in western Indonesia in the wet season. Moisture flux analysis indicates that corresponding to the dry (wet) season precipitation reduction due to the canonical El Niño and El Niño Modoki anomalous divergence occurs around the southern (northern) edge of the convergence zone when one of the two edges is located near the equator (10°S–15°N) associated with their seasonal migration. This largely explains the seasonality and regionality of precipitation responses to canonical El Niño and El Niño Modoki. IOD reduces precipitation in southwestern Indonesia in the dry season, associated with anomalous moisture flux divergence. The seasonality of precipitation response to IOD is likely to be controlled by the seasonality of local sea surface temperature anomalies in the eastern pole of the IOD.
IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy
Authors: Seethaler Alicia , Stenner Markus , McNally Annika , Rudack Claudia , Roth Johannes , Vogl Thomas , Spiekermann Christoph 
Published: March 2020

Objectives: Tonsillectomy (TE) and tonsillotomy (TO) due to recurrent episodes of acute tonsillitis (RAT) belong to the most frequent surgical procedures. However, an adequate objective marker predicting the outcome of TE/TO preoperatively is missing. Methods: Patients with RAT who underwent TE/TO (n = 31) were included in this pilot study. A panel of cytokines and chemokines in serum and saliva were determined preoperatively. Health-related quality of life was assessed pre- and postoperatively by the Tonsillectomy Outcome Inventory-14. Results: Health-related quality of life improved significantly after surgery. Increased serum levels of interleukin-8 (IL-8) and interferon gamma (IFN-γ) are associated with a less successful outcome. No correlation between the number of acute tonsillitis episodes and the health-related quality of life after TE or TO could be observed. Conclusions: Tonsillectomy and TO improve health-related quality of life independently from the number of past acute tonsillitis episodes. Interleukin-8 and IFN-γ in serum may serve as promising markers, predicting the benefit of TE or TO for patients preoperatively.
Subjective Benefits of Bimodal Listening in Cochlear Implant Recipients with Asymmetric Hearing Loss
Authors: Thompson Nicholas J. , Dillon Margaret T. , Buss Emily , Rooth Meredith A. , King English R. , Bucker Andrea L. , McCarthy Sarah A. , Deres Ellen J. , O’Connell Brendan P. , Pillsbury Harold C. , Brown Kevin D. 
Published: March 2020

ObjectiveTo investigate the influence of cochlear implant (CI) use on subjective benefits in quality of life in cases of asymmetric hearing loss (AHL).Study DesignProspective clinical trial.SettingTertiary academic center.Subjects and MethodsSubjects included CI recipients with AHL (n = 20), defined as moderate‐to‐profound hearing loss in the affected ear and mild‐to‐moderate hearing loss in the contralateral ear. Quality of life was assessed with the Speech, Spatial, and Qualities of Hearing Scale (SSQ) pragmatic subscales, which assess binaural benefits. Subjective benefit on the pragmatic subscales was compared to word recognition in quiet and spatial hearing abilities (ie, masked sentence recognition and localization).ResultsSubjects demonstrated an early, significant improvement (P <. 01) in abilities with the CI as compared to preoperative abilities on the SSQ pragmatic subscales by the 1‐month interval. Perceived abilities were either maintained or continued to improve over the study period. There were no significant correlations between results on the Speech in Quiet subscale and word recognition in quiet, the Speech in Speech Contexts subscale and masked sentence recognition, or the Localization subscale and sound field localization.ConclusionsCI recipients with AHL report a significant improvement in quality of life as measured by the SSQ pragmatic subscales over preoperative abilities. Reported improvements are observed as early as 1 month postactivation, which likely reflect the binaural benefits of listening with bimodal stimulation (CI and contralateral hearing aid). The SSQ pragmatic subscales may provide a more in‐depth insight into CI recipient experience as compared to behavioral sound field measures alone.
Response on DCE-MRI predicts outcome of salvage radiotherapy for local recurrence after radical prostatectomy
Authors: Sanguineti Giuseppe , Bertini Luca , Faiella Adriana , Ferriero Maria Consiglia , Marzi Simona , Farneti Alessia , Landoni Valeria 
Published: March 2020

Objective: To assess the predictive role of response on dynamic contrast enhancement on magnetic resonance imaging (DCE-MRI) of visible local lesions in the setting of salvage radiotherapy (sRT) after radical prostatectomy. Methods: All patients referred for sRT for biochemical failure after radical prostatectomy from February 2014 to September 2016 were considered eligible if they had been restaged with DCE-MRI and had been found to have a visible lesion in the prostatic bed, but no distant/nodal disease on choline positron emission tomography (PET)–computed tomography (CT). Eligible patients were contacted during follow-up and offered reimaging with serial DCE-MRI until lesion resolution. Complete response (CR) was defined as the disappearance of the target lesion on DCE-MRI; prostate-specific antigen (PSA) recurrence was defined as a 0.2 ng/mL PSA rise above the nadir. Median follow-up after sRT was 41.5 months (range, 12.1–61.2 months). Results: Fifty-nine patients agreed to undergo repeated DCE-MRI for a total of 64 studied lesions. Overall, 57 lesions (89.1%) showed a CR after 1 (51 patients) or 2 (6 patients) scans, while 7 lesions did not show any change (no response [NR]). At 42 months, no evidence of biochemical disease (bNED) survival was 74.7±6.4% and 64.3±21.0% for patients with CR and NR lesions, respectively (hazard ratio [HR], 3.181; 95% confidence interval [CI], 0.157–64.364; p = 0.451). When only patients treated with sRT without androgen deprivation were selected ( n = 41), bNED survival rates at 42 months were 72.1±8.0% and 0, respectively (HR, 52.830; 95% CI, 1.893–1474.110; p = 0.020). Conclusions: Patients whose lesions disappear during follow-up have a better outcome than those with unchanged lesions after sRT alone.
Cannabinoids use in adolescents and young adults with cancer: a single-center survey
Authors: Podda Marta , Pagani Bagliacca Elena , Sironi Giovanna , Veneroni Laura , Silva Matteo , Angi Martina , Massimino Maura , Ferrari Andrea , Clerici Carlo Alfredo 
Published: March 2020

Objective: To present an investigation into the intake of cannabinoids in a population of adolescents and young adults with cancer. Methods: Sixty-six patients took part in the research: 27 reported having used cannabinoids, 21 before diagnosis; among the latter, 10 increased use during treatment. Results: Benefits were reported by 19% of responders regarding anxiety control, 24% for nausea, 29% for pain control and improvement of sleep, and 48% for appetite improvement. Conclusions: Cannabis use by patients may often be unknown to caregivers. Studying this subject may help to better define important therapeutic aspects of these substances.
Hospital-based social workers’ perceptions of generalist- and specialist-level palliative social work activities
Authors: Firn Janice , Preston Nancy , Walshe Catherine 
Published: March 2020

Summary A social work advisory group recently proposed 41 generalist-level palliative social work activities applicable to any venue, including hospital-based social work, but this applicability has not been empirically tested. Therefore, we used critical realist grounded theory analysis of qualitative interviews to explore whether the activities proposed by the advisory group reflect inpatient social workers’ perceptions of their generalist-level palliative activities when caring for patients alongside specialist-level palliative social workers. Fourteen Masters educated social workers from six hospitals in the Midwest United States participated. Corresponding concepts from interview data of hospital-based social workers’ perceptions of what facilitates or hinders collaboration with specialist-level palliative social workers were identified and mapped onto the 41 generalist-level palliative social work activities. We used NVivo to organize and track data. Findings Inpatient social workers find it challenging to engage in specific generalist-level palliative social work activities; provision of generalist-level palliative services is shaped by discharge planning duties, the consultation model, and the concentrated role of specialist-level palliative social workers. Competency in cultural and spiritual aspects of care could be lacking. Applications Most of the 41 generalist-level palliative social work activities are present in hospital-based social workers’ clinical practice. However, not all activities may be applicable or realizable in the inpatient venue. In the hospital, an emphasis on discharge planning and related time-barriers can mean seriously ill patients and their families lack access to generalist-level palliative social work services. Clarification is needed about which of the 41 activities are relevant to and actionable within the inpatient venue.