bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I
Authors: Gregson J , Rhee S Y , Datir R , Pillay D , Perno C F , Derache A , Shafer R S , Gupta R K 
Published: November 2019

AbstractBackgroundM184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to retain modest activity against human immunodeficiency virus-1 with these mutations possibly as a result of reduced replication capacity. In this study, we determined how M184V/I impacts virus load (VL) in patients failing therapy on a TDF/XTC plus nonnucleoside reverse-transcriptase inhibitor (NNRTI)-containing regimen.MethodsWe compared VL in the absence and presence of M184V/I across studies using random effects meta-analysis. The effect of mutations on virus reverse-transcriptase activity and infectiousness was analyzed in vitro.ResultsM184I/V was present in 817 (56.5%) of 1445 individuals with virologic failure (VF). Virus load was similar in individuals with or without M184I/V (difference in log10 VL, 0.18; 95% confidence interval, .05–.31). CD4 count was lower both at initiation of antiretroviral therapy and at VF in participants who went on to develop M184V/I. L74I was present in 10.2% of persons with M184V/I but absent in persons without M184V/I (P &lt; .0001). In vitro, L74I compensated for defective replication of M184V-mutated virus.ConclusionsVirus loads were similar in persons with and without M184V/I during VF on a TDF/XTC/NNRTI-containing regimen. Therefore, we did not find evidence for a benefit of XTC in the context of first-line failure on this combination.
Characterizing non-heroin opioid overdoses using electronic health records
Authors: Averitt Amelia J , Slovis Benjamin H , Tariq Abdul A , Vawdrey David K , Perotte Adler J 
Published: November 2019

AbstractIntroductionThe opioid epidemic is a modern public health emergency. Common interventions to alleviate the opioid epidemic aim to discourage excessive prescription of opioids. However, these methods often take place over large municipal areas (state-level) and may fail to address the diversity that exists within each opioid case (individual-level). An intervention to combat the opioid epidemic that takes place at the individual-level would be preferable.MethodsThis research leverages computational tools and methods to characterize the opioid epidemic at the individual-level using the electronic health record data from a large, academic medical center. To better understand the characteristics of patients with opioid use disorder (OUD) we leveraged a self-controlled analysis to compare the healthcare encounters before and after an individual’s first overdose event recorded within the data. We further contrast these patients with matched, non-OUD controls to demonstrate the unique qualities of the OUD cohort.ResultsOur research confirms that the rate of opioid overdoses in our hospital significantly increased between 2006 and 2015 (P &lt; 0.001), at an average rate of 9% per year. We further found that the period just prior to the first overdose is marked by conditions of pain or malignancy, which may suggest that overdose stems from pharmaceutical opioids prescribed for these conditions.ConclusionsInformatics-based methodologies, like those presented here, may play a role in better understanding those individuals who suffer from opioid dependency and overdose, and may lead to future research and interventions that could successfully prevent morbidity and mortality associated with this epidemic.
Development and validation of the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME)1
Authors: Duysburgh Cindy , Ossieur Wendy P , De Paepe Kim , Van den Abbeele Pieter , Vichez-Vargas Ramiro , Vital Marius , Pieper Dietmar H , Van de Wiele Tom , Hesta Myriam , Possemiers Sam , Marzorati Massimo 
Published: November 2019

AbstractWhereas a wide variety of in vitro models have been developed and validated to assess the effect of specific food ingredients on the human gut microbiome, such models have only been developed and applied to a limited extent for companion animals. Since the use of pre- and probiotics to improve gut health is an emerging research topic in the field of companion animals and as dogs are often used as laboratory animals in developing and testing of pharmaceuticals, the current study aimed to establish an adequate canine in vitro model. This consisted of a four-stage reactor composed of a stomach and small intestinal compartment followed by a proximal and distal colon. This semi-continuous gastrointestinal tract model allowed a long-term, region-dependent, and pH-controlled simulation of the colon-associated microbial community of dogs. Upon reaching a functional steady state, the simulated canine microbial community composition proved to be representative of the in vivo situation. Indeed, the predominant bacterial phyla present in the in vitro proximal and distal colon corresponded with the main bacterial phyla detected in the fecal material of the dogs, resulting in an average community composition along the simulated canine gastrointestinal tract of 50.5% Firmicutes, 34.5% Bacteroidetes, 7.4% Fusobacteria, 4.9% Actinobacteria, and 2.7% Proteobacteria. A parallel in vivo–in vitro comparison assessing the effects of fructooligosaccharides (FOS) on the canine microbial community composition showed a consistent stimulation of Lactobacillus concentrations in the in vivo fecal samples as well as in the in vitro canine gut model. Furthermore, the in vitro platform provided additional insights about the prebiotic effect of FOS supplementation of dogs, such as a reduced abundance of Megamonas spp. which are only present in very low abundance in in vivo fecal samples, indicating an interesting application potential of the developed canine in vitro model in research related to gastrointestinal health of dogs.
Nontarget Host Risk Assessment of the Egg Parasitoid Trichogrammatoidea cryptophlebiae (Hymenoptera: Trichogrammatidae) for Classical Biological Control of the False Codling Moth (Lepidoptera: Tortricidae) in Israel
Authors: Kaspi Roy , Steinitz Hadass , Nemny-Lavi Esther , Lebedev Galina , Melamed Ester , Gazit Yoav 
Published: November 2019

Abstract
The false codling moth Thaumatotibia leucotreta (Meyrick), is an invasive species in Israel. In order to carry out a classical biological control program, the African egg parasitoid Trichogrammatoidea cryptophlebiae (Nagaraja) was recently introduced into Israel, and nontarget host risk assessment was performed as required. In no-choice tests we determined that T. cryptophlebiae was unable to develop in eggs of four nontarget Lepidopteran species: Pectinophora gossypiella (Saunders), Spodoptora littoralis (Boisduval), Ephestia kuehniella (Zeller), and Belenois aurota (Fabricius). Conversely, it developed in three Lepidopteran species eggs of the Tortricidae family: Cydia pomonella (Linnaeus), Lobesia botrana (Denis and Schiffermüller), and Epiblema strenuana (Walker). Epiblema strenuana eggs showed the lowest parasitism level among all tested moth eggs of the Tortricidae family. The progeny production of parasitized false codling moth eggs was similar to that of C. pomonella eggs, but smaller than that of L. botrana eggs. However, moth egg and parasitoid clutch sizes were smallest on L. botrana eggs and largest on C. pomonella eggs. In choice bioassays, T. cryptophlebiae significantly preferred to parasitize T. leucotreta eggs over the eggs of C. pomonella, L. botrana, and E. strenuana. Moreover, the choice of T. leucotreta eggs over the eggs of L. botrana was not affected by the parasitoids’ rearing histories. Our data support the assumption that T. cryptophlebiae develops only in moth species of the Tortricidae family. Thus, the risk that it may attack nontarget species is low.
Early Season Applications of Bifenthrin Suppress Host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) Nymphs
Authors: Schulze Terry L , Jordan Robert A 
Published: November 2019

Abstract
We assessed the efficacy of bifenthrin to suppress Ixodes scapularis Say and Amblyomma americanum (L.) nymphs when applied prior to the initiation of spring host-seeking activity versus when nymphs were already active. Treatment and control plots were sampled for host-seeking ticks every week from mid-April through June, and single occasion bifenthrin applications were done in different sets of treatment plots on 15 April, 29 April, 13 May, and 27 May. Ixodes scapularis nymphs and A. americanum nymphs and adults were effectively suppressed after each application, with at or near 100% suppression of all ticks being observed for up to 8-wk postapplication. Irrespective of the bifenthrin application date, the level of suppression of I. scapularis nymphs never declined below 70% during the study period. However, with the exception of the last application, the suppression of A. americanum nymphs decreased dramatically to below 25% by the conclusion of the trial. The results of this study demonstrated that preseason applications of bifenthrin can mitigate acarological risk of exposure to ticks throughout much of their spring peak activity period.
What Is Going on With the Genus Dermacentor? Hybridizations, Introgressions, Oh My!
Authors: Goddard Jerome , Allerdice Michelle , Portugal J Santos , Moraru Gail M , Paddock Christopher D , King Jonas 
Published: November 2019

Abstract
In the 1930s, R. A. Cooley noted that Dermacentor occidentalis (Acarina: Ixodidae) and Dermacentor andersoni were closely related and could hybridize. Decades later, James Oliver discovered that crosses of Dermacentor variabilis, D. andersoni, and D. occidentalis could, on occasion, produce hybrids. A recent molecular analysis (both mtDNA and nDNA) in our laboratory revealed that certain specimens of Dermacentor andersoni nested with Dermacentor parumapertus. Does this close relationship, along with the mito-nuclear discordance we have observed, mean D. andersoni and D. parumapertus are a single species? By contemporary taxonomic criteria, this seems improbable based on their distinctly different morphologies, host associations, and ecologies. This paper explores ideas related to mito-nuclear discordance, hybridization, and introgression (primarily) not only in these two species but also other members of the genus Dermacentor. Both D. andersoni and D. parumapertus can be found on the same hosts and have sympatric distributions, so introgression of genetic material by occasional cross-mating between these two species is possible. Further, the difficulty in applying specific species concepts in ticks has been recently pointed out and a unified agreement on an integrative species concepts could clearly be useful in this situation. With the discovery of D. parumapertus as a potential vector of Rickettsia parkeri and the historically recognized role of D. andersoni in transmission of Rickettsia rickettsii, understanding the specific status of each lineage of these species (and others in the genus) is extremely important from a public health perspective.
Identifying Cancer-Related Cognitive Impairment Using the FACT-Cog Perceived Cognitive Impairment
Authors: Dyk Kathleen Van , Crespi Catherine M , Petersen Laura , Ganz Patricia A 
Published: November 2019

Abstract
Cancer-related cognitive impairment (CRCI) is a concerning problem for many cancer survivors. Evaluating patients for CRCI has been a challenge, in part because of a lack of standardized practices. Self-report instruments are often used to assess CRCI, but there are no validated cutpoints. We present the results of receiver operating characteristic curve analysis identifying cutpoints of the Functional Assessment of Cancer Therapy—Cognition perceived cognitive impairment (PCI) in female breast cancer survivors for identifying CRCI cases. We defined presence of CRCI based on elevated complaints on the Patient’s Assessment of Own Functioning Inventory compared with healthy control scores. Our results indicate that scores less than 54 in PCI scores using 18 items and scores less than 60 in PCI scores using 20 items exhibited good ability to discriminate CRCI cases from noncases (area under the receiver operating characteristic curve was 0.84 [95% CI = 0.73 to 0.94]). These preliminary results represent an important contribution toward standardizing practices across CRCI studies.
Disjunction Triggers Exhaustivity Implicatures in 4- to 5-Year-Olds: Investigating the Role of Access to Alternatives
Authors: Gotzner Nicole , Barner David , Crain Stephen 
Published: November 2019

Abstract
Children’s difficulty deriving scalar implicatures has been attributed to a variety of factors including processing limitations, an inability to access scalar alternatives, and pragmatic tolerance. The present research explores the nature of children’s difficulty by investigating a previously unexplored kind of inference—an exhaustivity implicature that is triggered by disjunction. We reasoned that if children are able to draw quantity implicatures but have difficulties accessing alternative lexical expressions from a scale, then they should perform better on exhaustivity implicatures than on scalar implicatures, since the former do not require spontaneously accessing relevant scalar alternatives from the lexicon. We conducted two experiments. Experiment 1 found that 4- to 5-year-olds consistently computed exhaustivity implicatures to a greater extent than scalar implicatures. Experiment 2 demonstrated that children are more likely to compute exhaustivity implicatures with disjunction compared to conjunction. We conclude that children often fail to derive scalar implicatures because (1) they struggle to access scalar alternatives and (2) disjunction (but not conjunction) makes subdomain alternatives particularly salient. Thus, the findings suggest that exhaustivity implicatures can be derived without reference to a scale of alternatives.
Mechanical intestinal obstruction following laparoscopic inguinal hernia repair in a patient with abdominal cocoon syndrome
Authors: Park Geon Hi , Lee Byoung Chul , Hyun Dong woo , Choi Jung Bum , Park Young Mok , Jung Hyuk Jae , Jo Hong Jae 
Published: November 2019

Abstract
Abdominal cocoon syndrome (ACS) is a rare condition characterized by partial or complete encasement of small intestine by a thick fibro-collagenous membrane. A 65-year-old man presented to the surgical department with left inguinal. He underwent laparoscopic transabdominal preperitoneal inguinal hernia. When we inserted a trocar into the peritoneal cavity, the small intestine was injured and repaired immediately. We identified a fibrotic membrane covering the small intestine, which was found as ACS. Two weeks later after discharge, he presented to the emergency department with mechanical intestinal obstruction. Conservative treatment had no effect on the patient and membrane excision, adhesiolysis and small intestine resection with anastomosis were performed. Unfortunately, the patient was hospitalized for a long time with bowel leakage and discharged on postoperative day 48. The preoperative diagnosis is quite challenging and most cases are diagnosed intraoperatively. When finding the ACS during the operation, careful attention should be needed.
Non-stationary Antonov self-gravitating layer: analytics and numerics
Authors: Malkov Evgeny A , Kudryavtsev Alexey N 
Published: November 2019

ABSTRACTLarge-scale instability of gravitating systems plays a key role in collisionless relaxation and in reaching a quasi-stationary state at the early stage of evolution. Advanced high-resolution methods and permanently increasing performance of computational systems allow this phenomenon to be studied by means of computer simulations at a new level. In this paper, an approach to verification and validation of computer codes implementing high-resolution methods is proposed. The approach is based on comparisons of the simulation results with exact non-stationary solutions of the Vlasov–Poisson equations. The evolution of the gravitating layer model is considered as an example of implementation of this approach. A one-parameter family of exact models of a non-stationary gravitating layer is described, and their stability to large-scale disturbances in the linear approximation is analytically studied. Non-linear instability development is computed with the use of the fifth-order conservative semi-Lagrangian WENO scheme.
Spectral signatures of recursive magnetic field reconnection
Authors: Tenerani A , Velli M 
Published: November 2019

ABSTRACT
We use 2.5D magnetohydrodynamic simulations to investigate the spectral signatures of the non-linear disruption of a tearing unstable current sheet via the generation of multiple secondary current sheets and magnetic islands. During the non-linear phase of tearing mode evolution, there develops a regime in which the magnetic energy density shows a spectrum with a power law close to B(k)2 ∼ k−0.8. Such an energy spectrum is found in correspondence of the neutral line, within the diffusion region of the primary current sheet, where energy is conveyed towards smaller scales via a ‘recursive’ process of fast tearing-type instabilities. Far from the neutral line, we find that magnetic energy spectra evolve towards slopes compatible with the ‘standard’ Kolmogorov spectrum. Starting from a self-similar description of the non-linear stage at the neutral line, we provide a model that predicts a reconnecting magnetic field energy spectrum scaling as k−4/5, in good agreement with numerical results. An extension of the predicted power law to generic current sheet profiles is also given and possible implications for turbulence phenomenology are discussed. These results provide a step forward to understand the ‘recursive’ generation of magnetic islands (plasmoids), which has been proposed as a possible explanation for the energy release during flares, but which, more in general, can have an impact on the subsequent turbulent evolution of unstable sheets that naturally form in the high Lundquist number and collisionless plasmas found in most of the astrophysical environments.
Quantifying acetaldehyde in astronomical ices and laboratory analogues: IR spectra, intensities, 13C shifts, and radiation chemistry
Authors: Hudson Reggie L , Ferrante Robert F 
Published: November 2019

ABSTRACT
Acetaldehyde is of interest to astrochemists for its relevance to both interstellar and cometary chemistry, but little infrared (IR) spectral data have been published for the solid phases of this compound. Here we present IR spectra of three forms of solid acetaldehyde, with spectra for one form being published for the first time. Direct measurements of band strengths and absorption coefficients also are reported for the first time for amorphous aldehyde, the form of greatest interest for astrochemical work. An acetaldehyde band strength at ∼1350 cm−1 that has been used as a reference for about 20 yr is seen to be in error by about 80 per cent when compared to the direct measurements presented here. Spectra and peak positions also are presented for H13C(O)13CH3, and then used for the first identification of ketene as a radiation product of solid acetaldehyde.
Factors Influencing Smoking Among Indigenous Adolescents Aged 10–24 Years Living in Australia, New Zealand, Canada, and the United States: A Systematic Review
Authors: Heris Christina L , Chamberlain Catherine , Gubhaju Lina , Thomas David P , Eades Sandra J 
Published: November 2019

AbstractIntroductionSmoking rates are higher among Indigenous populations in most high-income countries with initiation primarily occurring in adolescence for all population groups. This review aims to identify protective and risk factors for smoking behavior among Indigenous adolescents and young adults.Aims and MethodsWe searched Medline, Embase, and Psychinfo for all original research published between January 2006 and December 2016 that reported influences on smoking for Indigenous adolescents or young adults aged 10–24 living in Australia, New Zealand, Canada, and the United States (US). Extracted data were coded to individual, social, and environmental level categories using a modified Theory of Triadic Influence framework.ResultsA total of 55 studies were included, 41 were descriptive quantitative and 14 qualitative, and 26 included Indigenous participants only. The majority were from the US (32). Frequently reported influences were at the individual and social levels such as increasing age; attitudes and knowledge; substance use; peer and family relationships; smoking norms; mental health; physical activity. At the environmental level, smoke-free spaces; second-hand smoke exposure; high community level prevalence; and social marketing campaigns were also frequently reported. Some studies referenced price, access, and traditional tobacco use. Few reported historical and cultural factors.ConclusionsYoung Indigenous people experience similar influences to other populations such as smoking among family and friends. Greater youth smoking is related to broader community level prevalence, but few studies explore the distal or historical contributing factors such as traditional tobacco use, colonization, experiences of intergenerational trauma and discrimination, or the role of cultural connection.ImplicationsThis review identified a range of factors that influence Indigenous youth smoking and contributes to an understanding of what prevention measures may be effective. Youth tobacco use occurs alongside other substance use and may also serve as an indicator of mental health. Comprehensive community-based programs that work more broadly to address the risk factors related to tobacco, including improving youth mental health, will be important for other behaviors as well. This research highlights the importance of social influence and need for ongoing denormalization of smoking. Future Indigenous led and community owned research is needed to identify likely protective cultural factors.
C2 Pedicle Screws Combined With C1 Laminar Hooks for Reducible Atlantoaxial Dislocation: An Ideal Salvage Technique for C1-C2 Pedicle Screws
Authors: Han Zhao , Yang Jun , Chen Qunxiang , Lu Xuhua , Chen Fei , Guo Xiang , Ni Bin , Guo Qunfeng 
Published: November 2019

Abstract

BACKGROUND
A C1 laminar hook can theoretically avoid vertebral artery injury and is less technically demanding. However, only few studies with small samples analyzed the short-term outcomes of C2 pedicle screws combined with C1 laminar hooks (C2PS-C1LH) technique in the treatment of atlantoaxial dislocation. Furthermore, it is not confirmed whether similar clinical outcomes can be achieved with C1-C2 pedicle screw and rod construct (PSRC).

OBJECTIVE
To evaluate the outcomes of C2PS-C1LH and C1-C2 PSRC fixation techniques for treating atlantoaxial dislocation.

METHODS
Data of 52 patients with atlantoaxial dislocation treated by C1-C2 PSRC or C2PS-C1LH fixation were retrospectively reviewed. Outcomes evaluated by visual analog scale score for neck pain (VASSNP), Neck Disability Index (NDI), atlantodental interval (ADI), and the perioperative parameters including blood loss and operation time were analyzed and compared between 2 techniques. Patient satisfaction at final follow-up was also investigated.

RESULTS
There were no complications related to the surgical approach and instrumentation in either group. The mean bone fusion time was 5.06 ± 1.65 mo for the C2PS-C1LH group and 3.93 ± 0.99 mo for the C1-C2 PSRC group (P > .05). Hundred percent of fusion rates were achieved in both groups at month 12 after operation. The ADI, VAS scores, the NDI scores, and the JOA scores were greatly improved in both the groups (P < .05), but there were no significant differences between the 2 groups.

CONCLUSION
C2PS-C1LH fixation technique was comparable to C1-C2 PSRC in the treatment of reducible atlantoaxial dislocation. C2PS-C1LH fixation was an ideal alternative strategy to C1-C2 PSRC fixation.