bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety, Depression and Functional impairment during the COVID-19 Pandemic among Health Care Workers
Authors: Shrestha Rajan , Khatri Bijay , Ranjitkar Suman , Adhikari Santoshi 
Published: August 2020

Abstract
BackgroundCOVID-19 is an infectious disease caused by a newly discovered coronavirus that is pandemic, with more than 338 thousand cases worldwide. Geometrically increasing numbers of cases and deaths from COVID 19 in the world, both medical staff and the public have been experiencing psychological problems, including anxiety, depression, and stress, which can cause disability and functional impairment of the individual. One of the most stressful situations is the unpredictability of the situation and the uncertainty of when to control the disease and the seriousness of the risk. These challenges and stress can trigger a common mental disorder. This study aimed to determine the burden of stress anxiety and depression among all employees of Eye and ENT hospitals.MethodologyA hospital-based cross-sectional study was carried out among all the employees of Hospital for Children Eye ENT and Rehabilitation Services Bhaktapur during the COVID-19 pandemic lockdown using an online self-administered questionnaire through Google forms. The tools were adopted from Hospital Anxiety and Depression scale (HADS) Nepali version on a Likert's scale of 0 to 3 validated by Risal A. et al. and WHO Disability Assessment Schedule (WHODAS S2.0) on a Likert's scale of 1 to 5 to assess functional impairment.ResultsThe mean age (SD) of the participants (n=86) was 32.53 (7.92) years. Male and female participants was equal in number. The point prevalence of anxiety and depression was 25.6% and 14.0%, respectively. Females had a higher prevalence of both anxiety (39.5% vs 11.6%, p<0.01) and depression (18.6% vs 9.3%, p=0.351). The mean (SD) anxiety, depression and functional impairment scores were 7.27 (4.621), 5.13 (4.023) and 19.47 (6.228), respectively. Females had a very strong association with both anxiety (AOR=5.008 (95% CI; 1.593-15.741)) and depression (AOR=2.173 (95% CI; 0.599-7.882)). Married participants had a positive association with anxiety (AOR 4.379 (95% CI; 1.121-17.106)) and depression (AOR 1.542 (95% CI; 0.379-6.276)). Clinical and supporting staff both had a higher prevalence of both anxiety (31.0% and 20.5%, p=0.265) and depression (16.7% and 11.4%, p=0.478). The mean 12-item WHO disability assessment schedule score (WHODAS 2.0) among all participants and participants with anxiety and depression was 19.47 (95% CI: 18.13-20.80), 21.27 (95% CI: 18.08-24.46) and 19.92 (15.28-24.56), respectively. The life activities domain of WHODAS 2.0 was significantly higher in participants with anxiety (1.91 vs 1.56, p<0.01) and depression (1.75 vs 1.63, p<0.001) than in those without anxiety.ConclusionAnxiety and depression during COVID-19 pandemic lockdown were highly prevalent both in clinical and non-clinical employees, causing mild to moderate functional impairment.
New in silico insights into the application of the (hydroxy)chloroquine with macrolide antibiotics co-crystals against the SARS-CoV-2 virus
Authors: de Castro Alexandre A. , Assis Letícia C. , Ramalho Teodorico C. , Porta Felipe A. La 
Published: August 2020

Abstract
In this in silico study, the different pharmaceutical co-crystals based on the (hydroxy)chloroquine with the macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) was analyzed for the first time. These findings present a new molecular perspective and, therefore, suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystals systems have less toxicity as well as is the most effective for inhibiting the new coronavirus SARS-CoV-2.
Polycyclic Aromatic Hydrocarbon Levels In Wistar Rats Exposed To Ambient Air Of Port Harcourt, Nigeria: An Indicator For Tissue Toxicity
Authors: Kanee Rogers B. , Ede Precious N. , Maduka Omosivie , Owhonda Golden , Aigbogun Eric O 
Published: August 2020

Abstract
Background: Over the years, the ambient air quality of Port Harcourt metropolis has deteriorated largely because of the petrochemical and hydrocarbon activities. This study, therefore, investigated the PAH levels in wistar rats exposed to ambient air of Port Harcourt metropolis.Method: Using an animal model, this study evaluated the blood PAH concentrations as an indicator of toxicity in living tissues exposed to ambient air polluted with particulate matter in Port Harcourt metropolis. Twenty (20) Wistar rats imported from a non-polluted city (Enugu) were exposed to both indoor and outdoor air for 90 days. Following the IACUC regulation, baseline data were obtained from 4 randomly selected animals, while the remaining 16 rats (8 each for indoor and outdoor) were left till day 90. Blood samples from the animals were obtained by cardiac puncture, and the PAHs concentrations were determined using Gas Chromatography Flame-Ionization Detector (GC-FID). GraphPad Prism (version 8.0.2) Sidak’s (for multiple data set) and unpaired t-tests (for two data sets) were used to evaluate the differences in group means at 95% confidence level.Result: Seven (7) of the PAHs found in indoor and outdoor rats were absent in blood tissues of baseline rats. The total mean concentrations of PAH were (82%), (13%), and (5%) in outdoor, indoor, and baseline animal groups respectively. Additionally, Dibenz(a,h)anthracene, Indeno(1,2,3-c,d)pyrene, Pyrene, 2-methyl, and other carcinogenic PAHs were all significantly higher (P<0.05) in outdoor samples when compared to the indoor and baseline samples.Conclusion: The results demonstrated that the ambient air of Port Harcourt was highly concentrated with PAHs. Vulnerable groups such as outdoor workers, pregnant women, children and infants, and terminally ill are the most susceptible to the health risks posed by these pollutants. Therefore, urgent environmental and public health measures are necessary to mitigate the looming danger.
An 8-lncRNA signature predicts survival of triple-negative breast cancer patients without germline BRCA1/2 mutation
Authors: Liu Minling , Dai Wei , Zhu Mengyuan , Li Xueying , Huang Shan , Wei Min , Li Lei , Fang Shuo 
Published: August 2020

Abstract
Background
Triple-negative breast cancer (TNBC) is a particular breast cancer subtype with poor prognosis due to its aggressive biological behavior and strong heterogeneity. TNBC with germline BRCA1/2 mutation (gBRCAm) have higher sensitivity to DNA damaging agents including platinum-based chemotherapy and PARP inhibitors. But the treatment of TNBC without gBRCAm remains challenging. This study aimed to develop a long non-coding RNA (lncRNA) signature of TNBC patients without gBRCAm to improve risk stratification and optimize individualized treatment.
Methods
98 TNBC patients without gBRCAm were acquired from The Cancer Genome Atlas (TCGA) database. The univariable Cox regression analysis and LASSO Cox regression model were applied to establish an lncRNA signature in the training cohort (N = 59). Then Kaplan–Meier survival curve and time-dependent ROC curve were used to validate the prognostic ability of the signature. The signature related mRNAs were identified using the Pearson correlation. Functional enrichment analysis of related mRNA was performed using the Metascape. The qPCR assay was performed to confirm the expressions and clinicopathological correlationsof two potential lncRNAs HAGLROS and TONSL-AS1 in 30 paired clinical triple-negative breast cancer samples without gBRCAm.
Results
We developed an 8-lncRNA signature in the training cohort including HAGLROS, AL139002.1, AL391244.2, AP000696.1, AL391056.1, AL513304.1, TONSL-AS1 and AL031008.1. In both the training and validation cohort, patients with higher risk scores showed significantly worse overall survival compared to those with lower risk scores(P = 0.00018 and P = 0.0068 respectively). 1, 5, 8-year AUC in the training cohort were 1.000, 1.000 and 0.908 respectively, in the validation cohort were 0.785, 0.790 and 0.892 respectively indicating that our signature has a good prognostic capacity. Signature related mRNA mainly enriched in terms include RNA metabolic process, DNA repair pathways, and so on. Two potential lncRNAs HAGLROS and TONSL-AS1 were found frequently overexpressed in TNBC without gBRCAm, and significantly associated with tumor grade and invasion.
Conclusions
We constructed a novel 8-lncRNA signaturewhich significantly associated with the overall survival of TNBC patients without gBRCAm. Among those 8lncRNAs, HAGLROS and TONSL-AS1 may be potential therapeutic targetswhich function needed further exploration.
Impact of environmental indicators on the COVID-19 pandemic in Delhi, India
Authors: Mangla Sherry , Pathak Ashok Kumar , Sahoo Prafulla Kumar 
Published: August 2020

Abstract

Currently there is a huge debate on whether meteorological and air quality parameters are playing a crucial role in the transmission of COVID-19 across the globe. On this background, this study aims to evaluate the impact of air pollutants (PM2.5, PM10, CO, NOx, SO2, AQI), and meteorological parameters (temperature, humidity, wind speed, and rainfall) on the spread, recoveries and mortality due to COVID-19 outbreak in Delhi. Spearman’s correlation method is employed on a secondary data collected from the Ministry of Environment, India and the COVID-19 data collected using daily government health bulletins for Delhi. Our result shows that the COVID-19 incidences are significantly positively correlated with temperature (r infections= 0.90, r recoveries= 0.84, r deaths= 0.83, p<0.05) and negatively correlated with humidity (r infections = -0.63, r recoveries = -0.58, r deaths = -0.56, p<0.05). This finding indicates that temperature and humidity play a significant role on the infections, recoveries and deaths due to the COVID-19. The study results may be useful for policymakers in managing the outbreak of COVID-19 in Delhi, India.
Primary Mucinous Adenocarcinoma of the Testis: A Case Report and Review of the Literature
Authors: Lei Haoran , Lai Li , Xu Hang , Bai Shengjiang , Shi Ming , Yang Lu 
Published: August 2020

Abstract
Background: Primary ovarian surface epithelial carcinoma of testis and paratestis is very rare, especially mucinous subtype. We report a case of a 48-year-old man with primary mucinous adenocarcinoma of the testis and discuss its gross, histological and immunohistochemical features based on limited reports.Case presentation: A case of a 48-year-old male patient with mucinous adenocarcinoma of the testis is reported. The tumor was confined to the testis and separated from the epididymis. The tumor has neither interstitial infiltration nor metastasis to other organs, nor ovarian or germ cell tumor components. Immunohistochemical analysis showed that the tumor epithelial cells expressed CK20, CK7, CDX-2 proteins, whereas expression of SATB2 was absent. Ki-67 protein was weakly expressed in epithelial cells. The mucinous adenocarcinoma in the present case had the immunohistochemical characteristics of intestinal mucosa.Conclusions: Primary mucinous adenocarcinoma of the testis is rare and there is no standard treatment. The main treatment is surgical resection, but there is no effective treatment for metastatic tumors. Paclitaxel, platinum-based chemotherapeutics may have some curative effects, but there is still a lack of robust clinical evidence.
An Image-Based Mobile Health App for Postdrainage Monitoring: Usability Study
Authors: Liao Chien-Hung , Wu Yu-Tung , Cheng Chi-Tung , Ooyang Chun-Hsiang , Kang Shih-Ching , Fu Chih-Yuan , Hsu Yu-Pao , Hsieh Chi-Hsun , Chen Chih-Chi 
Published: August 2020

Background
The application of mobile health (mHealth) platforms to monitor recovery in the postdischarge period has increased in recent years. Despite widespread enthusiasm for mHealth, few studies have evaluated the usability and user experience of mHealth in patients with surgical drainage.

Objective
Our objectives were to (1) develop an image-based smartphone app, SurgCare, for postdrainage monitoring and (2) determine the feasibility and clinical value of the use of SurgCare by patients with drainage.

Methods
We enrolled 80 patients with biliary or peritoneal drainage in this study. A total of 50 patients were assigned to the SurgCare group, who recorded drainage monitoring data with the smartphone app; and 30 patients who manually recorded the data were assigned to the conventional group. The patients continued to record data until drain removal. The primary aim was to validate feasibility for the user, which was defined as the proportion of patients using each element of the system. Moreover, the secondary aim was to evaluate the association of compliance with SurgCare and the occurrence of unexpected events.

Results
The average submission duration was 14.98 days, and the overall daily submission rate was 84.2%. The average system usability scale was 83.7 (SD 3.5). This system met the definition of “definitely feasible” in 34 patients, “possibly feasible” in 10 patients, and “not feasible” in 3 patients. We found that the occurrence rates of complications in the SurgCare group and the conventional group were 6% and 26%, respectively, with statistically significant differences P=.03. The rate of unexpected hospital return was lower in the SurgCare group (6%) than in the conventional groups (26%) (P=.03).

Conclusions
Patients can learn to use a smartphone app for postdischarge drainage monitoring with high levels of user satisfaction. We also identified a high degree of compliance with app-based drainage-recording design features, which is an aspect of mHealth that can improve surgical care.
Connected Mental Health: Systematic Mapping Study
Authors: Drissi Nidal , Ouhbi Sofia , Janati Idrissi Mohammed Abdou , Fernandez-Luque Luis , Ghogho Mounir 
Published: August 2020

BackgroundAlthough mental health issues constitute an increasing global burden affecting a large number of people, the mental health care industry is still facing several care delivery barriers such as stigma, education, and cost. Connected mental health (CMH), which refers to the use of information and communication technologies in mental health care, can assist in overcoming these barriers.ObjectiveThe aim of this systematic mapping study is to provide an overview and a structured understanding of CMH literature available in the Scopus database.MethodsA total of 289 selected publications were analyzed based on 8 classification criteria: publication year, publication source, research type, contribution type, empirical type, mental health issues, targeted cohort groups, and countries where the empirically evaluated studies were conducted.ResultsThe results showed that there was an increasing interest in CMH publications; journals were the main publication channels of the selected papers; exploratory research was the dominant research type; advantages and challenges of the use of technology for mental health care were the most investigated subjects; most of the selected studies had not been evaluated empirically; depression and anxiety were the most addressed mental disorders; young people were the most targeted cohort groups in the selected publications; and Australia, followed by the United States, was the country where most empirically evaluated studies were conducted.ConclusionsCMH is a promising research field to present novel approaches to assist in the management, treatment, and diagnosis of mental health issues that can help overcome existing mental health care delivery barriers. Future research should be shifted toward providing evidence-based studies to examine the effectiveness of CMH solutions and identify related issues.
Фармакологическая коррекция нейрогенной дисфункции нижних мочевых путей у детей
Authors: Borysova T.P. , Fedko T.V. , Nikolaenko T.A. , Boyko M.V. , Ostrovskaya O.A. , Obertinsky A.V. , Shevchenko K.V. 
Published: August 2020

Цель: оценить эффективность и безопасность фармакологической коррекции нейрогенной дисфункции нижних мочевых путей у детей препаратом ноофен (фенибут) в сочетании с профилактической дозой препарата фурамаг. Материалы и методы. Под наблюдением находились 24 ребенка в возрасте от 5 до 8 лет с жалобами на учащенное мочеиспускание в дневное время. Всем больным проводилось уронефрологическое и неврологическое обследование. Оценивались данные анамнеза заболевания, соматического статуса, общий анализ мочи, бактериологический посев мочи на флору. Для оценки уродинамики нижних мочевых путей изучались дневник мочеиспусканий, ультразвуковое исследование почек и мочевого пузыря, урофлоуметрия. Проводилась оценка психоневрологического статуса, а именно: симптомов нарушения внимания, гиперактивности и импульсивности. Детям в течение 28 дней назначались стандартная уротерапия и препарат ноофен, профилактическая доза препарата фурамаг, витамины группы В. Результаты. После обследования были диагностированы гиперактивный мочевой пузырь у 15 (62,5 %), дисфункциональное мочеиспускание у 9 (37,5 %) детей. По окончании лечения положительная динамика клинической картины отмечена у 21 (87 %) пациента, из них полное выздоровление наблюдалось у 9 (38 %), частичное улучшение — у 12 (49 %) детей. Отсутствие эффекта от проводимой терапии отмечено у 3 (13 %) детей. Изменение частоты мочеиспусканий на фоне терапии характеризовалось значительным снижением в первые две недели лечения с 16,00 ± 1,35 до 11,10 ± 0,57 (р < 0,001). По окончании терапии частота мочеиспусканий составила 8,90 ± 0,35 (р < 0,001). Ургентные позывы к мочеиспусканию практически ликвидировались, недержание мочи не отмечалось к завершению наблюдения. После курса лечения эффективный объем мочевого пузыря увеличился на 38,9 % (р < 0,001). Показано положительное влияние на уродинамические показатели: увеличение объема мочеиспускания (на 35,1 %, р < 0,001), максимальной (на 28,8 %, р < 0,002) и средней объемной скорости потока мочи (на 53,3 %, р < 0,001). За время наблюдения у обследованных детей не отмечено ни одного случая инфекции мочевых путей. Доказаны корригирующее влияние препарата ноофен на симптомы невнимательности и в большей степени гиперактивности/импульсивности, а также значимость связи эффективности лечения дисфункции нижних мочевых путей и психоневрологической положительной динамики (р < 0,004). Показан благоприятный профиль безопасности препаратов ноофен и фурамаг. Выводы. Установлена терапевтическая эффективность и безопасность препарата ноофен в сочетании с профилактической дозой препарата фурамаг при нейрогенной дисфункции нижних мочевых путей у детей, что подтверждалось положительной клинической динамикой, улучшением уродинамических показателей, снижением симптомов невнимательности, гиперактивности и импульсивности.
Случай вторичного AA-амилоидоза при болезни Бехтерева: успешная 3-летняя терапия адалимумабом
Authors: Ivanov D.D. , Fedorenko O.H. , Dyadik O.O. 
Published: August 2020

Описано клиническое наблюдение пациента, страдающего более 20 лет ревматологическим процессом, который идентифицирован как болезнь Бехтерева в последние 5 лет. Прогрессирование анкилозирующего спондилита осложнилось развитием нефротического синдрома и прогрессирующим снижением функции почек до уровня хронической болезни почек 4-й стадии (расчетная скорость клубочковой фильтрации (рСКФ) — 19,8 мл/мин), анемии и кахексии. Биопсия десны не выявила амилоида, биопсия почки подтвердила наличие АА-амилоидоза. Была начата терапия адалимумабом в дозе 40 мг 1 раз в неделю, через 2 месяца — 1 раз в 2 недели. Одновременно пациент получал олмесартан, симптоматическую терапию. Трехлетнее введение адалимумаба привело к стойкому контролю активности анкилозирующего спондилита и постепенному восстановлению функции почек до рСКФ 62 мл/мин. На фоне лечения у пациента родились дети. Приведена детальная характеристика нефробиоптата. Лечение адалимумабом и олмесартаном продолжается.
Маркеры апоптоза и прогрессирования глаукомной оптической нейропатии после хирургического лечения первичной открытоугольной глаукомы
Authors: Mogilevskyy S.Yu. , Serdyuk A.V. , Ziablitsev S.V. 
Published: August 2020

Актуальность. Механизмы апоптоза нейронов зрительного нерва при первичной открытоугольной глаукоме (ПОУГ) продолжают изучаться; установлено, что маркерами этого процесса являются фактор некроза опухоли α (TNF-α), Fas-лиганд (FasL) и растворимая форма Fas-рецептора (sFas/АРО-1). Цель исследования: исследовать связь маркеров апоптоза (TNF-α, FasL и sFas/АРО-1) с прогрессированием глаукомной оптической нейропатии после хирургического лечения первичной открытоугольной глаукомы. Материалы и методы. Обследовано 69 пациентов (69 глаз) с ПОУГ I–III стадий, которым выполняли трабекулэктомию с имплантацией шунта Ex-Press. Во внутриглазной жидкости (ВГЖ) определяли указанные маркеры методом иммуноферментного анализа. Повторное офтальмологическое обследование проводили через 1 год. Контрольную группу составили 25 пациентов, прооперированных по поводу возрастной катаракты. Статистический анализ проводили с помощью программ SPSS 11.0, MedStat. Результаты. Внутриглазное давление через три месяца после операции при наличии или отсутствии послеоперационного прогрессирования оптической нейропатии не отличалось. Содержание TNF-α было максимальным при 3-й стадии ПОУГ и превышало значение в контроле в 2,3 раза (p < 0,001). Аналогичные различия отмечены по содержанию FasL, которое было максимальным при 3-й стадии и превышало контроль в 1,9 раза (p < 0,001). Содержание sFas/APO-1 по стадиям ПОУГ было ниже (р < 0,001). Уровень TNF-α и FasL был выше при послеоперационном прогрессировании оптической нейропатии, тогда как содержание sFas/APO-1 было меньше (p < 0,001). Максимальная абсолютная разница отмечена для sFas/APO-1 (в 2,5 раза), меньшая — для TNF-α (в 1,7 раза) и FasL (в 1,6 раза). Выводы. Сопоставление полученных данных с литературными указывает на важную патогенетическую роль маркеров апоптоза и возможность их использования для прогнозирования развития ПОУГ и ее прогрессирования после хирургического лечения.
Peningkatan Prestasi Belajar PKN Materi Sistem Pemerintahan Indonesia Melalui Metode Contextual Teaching and Learning Bagis Siswa Kelas VI SD Negeri Combongan
Authors: Listyaningsih Listyaningsih 
Published: August 2020

ABSTRAKPenelitian ini bertujuan untukmeningkatkan kualitas proses pembelajaran dan prestasi belajar PKn materi sistem pemerintahan Indonesia bagi siswa kelas VI SD Negeri Combongan 01 Kecamatan Sukoharjo Semester 1 Tahun Pelajaran 2018/2019 melalui metode Contextual Teaching and Learning.Penelitian ini merupakan penelitian tindakan kelas. Penelitian dilakukan di SD Negeri Combongan 01 Kecamatan Sukoharjo, Kabupaten Sukoharjo pada semester 1 tahun pelajaran 2018/2019selama 6 (enam) bulan. Subjek penelitian adalah siswa kelas VISD Negeri Combongan 01 Kecamatan Sukoharjoyang terdiri dari 15 orang siswa.Metode penelitian yang diterapkan adalah Contextual Teaching and Learning dengan prosedur penelitian yaitu: 1) perencanaan; 2) pelaksanaan;3) observasi; dan 4) refleksi.Hasil penelitian ini menunjukaan adanya peningkatan kualitas pembelajaran dan prestasi belajar siswa. Peningkatan kualitas belajar terbukti dengan meningkatnya jumlah siswa yang mendapatkan kriteria baik dalam proses pembelajaran yakni pada kondisi awal sebesar 40,00% meningkat menjadi 100% pada akhir siklus II. Peningakatan prestasi belajar siswa dibuktikan dengan meningkatnya nilai rata-rata prestasi belajar siswa serta ketuntasan belajar siswa secara klasikal. Nilai rata-rata prestasi belajar siswa pada Kondisi Awal sebesar 69,67meningkat menjadi 82,00 pada akhir siklus II, sehingga mengalami peningkatan sebesar 12,33. Ditinjau dari ketuntasan belajar siswa secara kelasikal yakni pada Kondisi Awal sebesar 53,33% meningkat menjadi 100% pada akhir Siklus II, sehingga mengalami peningkatan 46,67%.Penelitian ini menyimpulkan bahwapenggunaan metode Contextual Teaching and Learning dapat meningkatkan kualitas proses pembelajaran dan prestasi belajar PKn materi sistem pemerintahan Indonesia bagi siswa kelas VI SD Negeri Combongan 01 Kecamatan Sukoharjo Semester 1 Tahun Pelajaran 2018/2019.Â Â Kata Kunci:Contextual Teaching and Learning, PKn, Prestasi belajar