bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Metastatic Lymph Nodes to Totally Removed Lymph Nodes Ratio in Breast Cancer?
Authors: Cihan Yasemin Benderli 
Published: November 2020

Abstract
To determine prognostic ratio of metastatic lymph nodes to totally removed lymph nodes (MLN/TRLN) on overall and progressionfree survival with diagnosis of breast cancer. Radiation Oncology department of Kayseri Training and Research Hospital, relationship of MLN/TRLN between prognosis and other prognostic factors was evaluated in T1-3 and N1-3 non-metastatic breast cancer patients. Two hundred female patients and 5 male patients with an average age of 56 years were enrolled in this study. Of all patients, 63.4% of the patients were postmenopausal and modified radical mastectomy was performed in 96.6% of them. While 93.2% of the patients were diagnosed with invasive ductal carcinoma, 52.7% of them had clinical N1 disease, 62% of them were staged as T2, 94% of them received chemotherapy and 57.1% of them received hormonal therapy. Metastatic lymph node ratio below 0.2 was 48.8%, between 0.21-0.65 it was 35.1% and above 0.65% it was 16.1%. Five-year Overall survival and progressionfree survival rates were 76% and 58% respectively. Statistically significant difference was found between MLN/TRLN and age (p=0.044), chemotherapy (p=0.039), pathological lymph nodes (p <0.001) according to Pearson's Chi-Squared test. Factor affecting overall survival was Progesterone receptor status (p=0.021) and for progression-free survival they were gender (p=0.003) and human epidermal growth factor receptor 2 (p=0.018). Univariate and multivariate analysis found that gender (p=0.04, OR 5.9, CI: 1.7-19.6) and lymph node (p=0.05, OR: 1.4, CI: 0.9-2.1) were significant factors affecting progressionfree survival.
MLN/TRLN was shown to have no effect on prognosis in non-metastatic breast cancer patients due to small number of patients and short follow-up period.
Shift-work: a review of the health consequences
Authors: Silva Ana , Silva André , Duarte J. , Torres da Costa J. 
Published: November 2020

Shift work has become a common practice across many sectors during the past decades as a result of the growing demands of human life. There are many possibilities to organize shift schedules, however, all of them, some more than others, impose serious impacts on the individual´s health, social life and organization level. Thus, we conducted a review using Scopus, Science Direct and Web of Science, and using the keywords and criteria deemed appropriate, with the main objective of identifying the main consequences that have been positively associated with shift work at several domains to this day. The results of this review indicated that shift work and everything that this type of work implies, can lead to severe health consequences, namely sleep disorders, psychiatric disorders, gastrointestinal disturbances, metabolic disorders, cardiovascular disease, urologic disorders and even some types of cancer. These health consequences arise due to the disruption of the circadian clock system, which is associated with alterations at genetic level. Moreover, shift work also causes impacts in social life, as the individual may experience more difficulties in socializing with family and friends, which may lead to isolation and organization level, as excessive sleepiness, stress and dissatisfaction may lead to a detriment of the performance and alertness, which may result in more accidents. In conclusion, considering the nefarious effects that this type of organization of working time can impose, primarily for the worker, but also for the worker’s family and also organization in which this works, it is crucial that the organization seek to protect the worker safety and health, which can be achieved by consultation the working physician but also with the use of tools that allow monitoring the worker health and general cognitive state.
PENGARUH CHANGE ORDER TERHADAP BIAYA, MUTU, DAN WAKTU PADA PROYEK KONSTRUKSI GEDUNG BERTINGKAT
Authors: Putra Hendy Eka , Sulistio Hendrik 
Published: November 2020

The implementation of the construction project caused miscommunication, this made the contract became a reference during implementation. In the implementation of construction projects, there are often changes that not according to contract, for example: work volume changes, specifications changes, type or method of work changes, schedules changes , design changes, and others. These changes are commonly known as change orders. There are several things that cause a change order, for example: incompletable contract, design does not fit in the field, unsupportive weather, and others. This research is to determine the effect of change order in the aspects of cost, quality, and time in multi-storey building construction projects. Researchers used data from the responses of respondents consisting of contractors, consultants, and owners. The questionnaire made proposes several aspects of change orders and their effects on cost, quality, and time. Analysis of research data was carried out with the help of the SmartPLS 3.0 application program. The influence of change orders on costs is the lack of costs due to the addition of work items, while on quality is the quality decrease due to additional work volume, and on time is the delay in project completion due to changes in completed work.ABSTRAKPelaksanaan proyek konstruksi menyebabkan terjadi perbedaan pendapat yang disebabkan oleh pihak yang terlibat, hal ini membuat kontrak menjadi sangat penting dan menjadi acuan selama pelaksanaan. Pada pelaksanaan proyek konstruksi sering terjadi perubahan-perubahan yang akhirnya tidak sesuai dengan kontrak sebelumnya contohnya seperti: perubahan volume pekerjaan, perubahan spesifikasi, perubahan jenis atau metode pekerjaan, perubahan jadwal, perubahan design, dan lain-lain. Perubahan ini umum sekali terjadi dalam proyek konstruksi dan lebih sering dikenal sebagai change order. Ada beberapa hal yang menyebabkan perlunya dilakukan change order, misalnya: kontrak yang dibuat tidak lengkap, design yang ada tidak sesuai dengan kondisi lapangan, cuaca yang tidak mendukung, dan lain-lain. Penelitian ini dilakukan untuk mengetahui besar pengaruh change order dalam aspek biaya, mutu, dan waktu dalam proyek konstruksi gedung bertingkat. Peneliti menggunakan data dari hasil tanggapan responden yang terdiri dari kontraktor, konsultan, dan pemilik. Kuesioner yang dibuat mengajukan beberapa aspek mengenai change order serta pengaruhnya terhadap biaya, mutu, dan waktu. Analisis data penelitian dilakukan dengan bantuan program aplikasi SmartPLS 3.0. Pengaruh change order terhadap biaya adalah kurangnya biaya akibat penambahan item pekerjaan, sedangkan terhadap mutu adalah menurunnya kualitas bangunan akibat penambahan volume pekerjaan, dan terhadap waktu adalah terjadinya keterlambatan penyelesaian proyek akibat perubahan pekerjaan yang telah selesai.
ANALISIS KOEFISIEN PEKERJAAN PEMBESIAN PADA KONSTRUKSI GEDUNG BERTINGKAT
Authors: Leonardy Eric , Sekarsari Jane 
Published: November 2020

Accurate estimate is very necessary before a project run. The goals get a time and money efficiency with good quality. Cost estimation has an important element, namely the coefficient value. There are often problems in calculating prices caused by coefficient values. This study was conducted to find out whether the will gain better than the reference coefficient values in SNI 7394-2008 and PermenPUPR28-2016. Data is taken from 2 studies that discuss the iron fabricating. Processing data into coefficient values using a method known as Time motion and Study, and the calculation get the results that study A has a coefficient ratio of 22,86% and 11,43% in SNI 7394-2008 and PermenPUPR28-2016 while study B gets a coefficient comparison of 468,57% and 234,29% in SNI 7394-2008 and PermenPUPR28-2016. This happens because of the effect of worker productivity and the number of workers used on the data from each study. The results can be concluded that calculating the coefficient value of workers recommended to be done. This is to know whether the coefficient of workers used is more efficient than the coefficient values from references, because the coefficient of workers are not always better than the coefficients in the references. ABSTRAKMelakukan estimasi yang akurat adalah sangat perlu sebelum suatu proyek akan berjalan. Tujuannya mendapatkan biaya yang kecil, waktu yang cepat, dan mutu yang baik agar proyek berjalan tanpa hambatan. Estimasi biaya memiliki elemen penting, yaitu nilai koefisien. Namun sering terjadi permasalahan pada perhitungan harga yang disebabkan nilai koefisien. Maka studi dilakukan untuk mengetahui apakah nilai koefisien dai pekerja yang digunakan akan menghasilkan nilai yang lebih baik dibandingkan nilai koefisien acuan pada SNI7394-2008 dan PermenPUPR28-2016. Data diambil dari 2 studi yang membahas mengenai pekerjaan pembesian. Kemudian pengolahan data produktivitas menjadi nilai koefisien menggunakan metode yang dikenal dengan Time motion and Study, dan hasil perhitungan mendapatkan hasil bahwa studi A memiliki perbandingan koefisien 22,86% dan 11,43% pada SNI7394-2008 dan PermenPUPR28-2016 sedangkan studi B mendapatkan perbandingan koefisien 468,57% dan 234,29% pada SNI7394-2008 dan PermenPUPR28-2016. Hal ini terjadi karena pengaruh produktivitas pekerja dan jumlah pekerja yang digunakan pada data dari tiap studi. Hasil perhitungan dapat disimpulkan bahwa melakukan perhitungan nilai koefisien pekerja sangat disarankan untuk dilakukan. Hal ini untuk mengetahui apakah nilai koefisien pekerja yang digunakan lebih efisien dibandingkan nilai koefisien dari acuan yang sudah ada, karena koefisien pekerja yang digunakan belum tentu lebih baik dibandingkan koefisien pada acuan SNI7394-2006 dan PermenPUPR28-2016.
The Expression of Different Micrornas in Iraqi Patients with Childhood Acute Leukemia and Their Association to C/EBP-Î’ Serum Level
Authors: Al Nakeeb Rowshen Hani , Alrubaye Dalal 
Published: November 2020

Leukemia is the most common cancer in children which causes death despite the high survival rate. Therefore, new methods are required to find a suitable therapy. A small RNA called microRNAs (miRNAs) is used as a biomarker for cancer diagnosis and early prognostic evaluation. Expression levels of three miRNAs from the 3' arm (miR-142-3p, miR-223-3p and miR-146-3p) were detected in serum samples from 30 acute leukemic children and from 30 healthy individuals by using qPCR. The miR-142-3p and miR-146-3p profiles were significantly downregulated (P=0.0010 and 0.0012, respectively), while miR-223 was found to be significantly upregulated (P= 0.0044) in the pateints. Serum level of C/EBP-Î² (CCAAT-enhancer-binding protein) was also determined by enzyme-linked immunosorbent assay (ELISA) and showed a significantly higher level in the patients (pâ‰¤0.0001). However, this higher enhancer level is probably not the reason for the abovementioned differences in miRNAs expression, as indicated by the weak correlation values with the three miRNA molecules (0.5737, 0.6625 and 0.7769, respectively). In conclusion, the fold change of miR-142-3p, miR-223-3p and miR-146-3p in serum could be potentially used as an early indicator of the occurrence of acute leukemia in children.
A marked Copy of the Manuscriptinfluence of Oxyr on Susceptibility of Planktonic and Sessile Escherichia Coli Cultures to Ciprofloxacin and Cefotaxime
Authors: Samoilova Zoya , Muzyka Nadezhda , Smirnova Galina , Oktyabrsky Oleg 
Published: November 2020

Alternation of bacterial antioxidant defense pathways might affect susceptibility to antibiotics in dual ways. Using a relatively simple model based on wild-type and oxyR Escherichia coli mature biofilms, their counterpart planktonic cultures and exponentially growing planktonic cultures, we explored the role of OxyR-mediated metabolism alternations in modulation of susceptibility to antibiotics ciprofloxacin and cefotaxime. All three types of cultures were placed in fresh medium,1 h after antibiotics were added and incubation continued further for 2 h. Killing rates of antibiotics were determined, biofilm eradication using crystal violet assay was estimated, expression of rpoS, katG, sulA genes as well as HPI and HPII catalase activity were measured. Biofilms of both strains were more recalcitrant to ciprofloxacin and cefotaxime at all tested concentrations compared to exponentially growing planktonic cultures. In oxyR biofilms killing rate of ciprofloxacin was lower, and killing rate of cefotaxime was higher compared to the parental strain. Compared to biofilms, wild-type biofilm counterpart planktonic cultures showed higher tolerance to low doses of ciprofloxacin, while oxyR plankton demonstrated higher tolerance to cefotaxime. Higher recalcitrance of oxyR biofilms to ciprofloxacin may be caused by an increase in persister cells under conditions of enhanced oxidative stress and activated SOS response.
A Spotter's Guide to Dispersion in Surface-Confined Voltammetry Experiments
Authors: Lloyd-Laney Henry , Robinson Martin , Bond Alan , Parkin Alison , Gavaghan David 
Published: November 2020

This paper describes the effect of thermodynamic and kinetic dispersion on numerical simulations of three different surface-confined voltammetry experiments, ramped FTACV, Purely sinusoidal voltammetry (PSV) and direct current voltammetry (DCV), and the differences between the dispersed and non-dispersed cases. Dispersion in this case refers to a range of observed values for the thermodynamic driving force and reaction rate of a redox reaction (thermodynamic and kinetic dispersion respectively) . This has been acknowledged as a complicating factor of voltammetry experiments for some time. We demonstrate that thermodynamic dispersion has a far stronger effect than kinetic dispersion, and detail the ways in which kinetic dispersion can be resolved under such conditions. The work is novel in its comparison of three separate voltammetry techniques, and a focus on how to determine the presence of dispersion through computational analysis of experimental voltammetry data alone; previous work has required specific experiments designed to distinguish between dispersed and non-dispersed cases.
Applied aspects of human geography. A critical approach to traditionalist views
Authors: Mihaylov Valentin 
Published: November 2020

Traditionally, applied aspects of human geography are mainly associated with economic geography, regional development and spatial planning.
In the debate on the application potential of the discipline, a number of important problems of social, political and cultural geography, relevant to various contemporary processes on a global and regional scale, are marginalized. For this reason, the author undertakes a critical rethinking of the current debate on the applied aspects of research in human geography.
A brief review of the conceptual and institutional development of applied geography in the world and in selected national schools is made. The author also distinguishes two research orientations: 1) strategic orientation – connected to studies carried out at the international, national and macro-regional spatial levels; 2) operational orientation – concerning applied studies undertook on a scale of separate municipalities, cities, neighbourhoods or even separate streets and buildings.
Taking an attempt to overcome the narrow understandings of the frameworks of applied human geography, the author presents a new definition and tries to identify the main challenges for geographers that work in the field of Human Geography. Applied aspects of basic directions of human geography from the point of view of their broader interdisciplinary ties are also indicated.
Development of Environment-Friendly Concrete through Partial Addition of Waste Glass Powder (WGP) as Cement Replacement
Authors: Khan Fasih Ahmed , Shahzada Khan , Sami Ullah Qazi , Fahim Muhammad , Khan Sajjad Wali , Badrashi Yasir Irfan 
Published: November 2020

This paper presents the study carried out on the utilization of Waste Glass Powder (WGP) as supplementary cementitious material in concrete. The evaluation of the influence of WGP on the mechanical properties of concrete was carried out by casting and testing of concrete samples as per ASTM standards (cylinders and beam elements). The control samples were designed to represent field conditions with a target compressive strength of 20,000 kPa. The Portland cement in concrete was substituted with WGP in proportions of 0%-35% by weight, in increments of 5%. Two curing domains were adopted in the preparation of the test samples to evaluate the effect of pozzolanic material wherein the tested samples were cured for 28, 56, and 84 days. The study results indicated a reduction in compressive strength of concrete up to 10% with partial replacement of cement with 25% of WGP when standard curing of 28 days was adopted. Furthermore, with the same replacement proportion and prolonged curing for 84 days, the gap in strength reduction was reduced by 5%. However, a significant decrease in workability was noted between the control concrete samples and glass powder infused concrete. Furthermore, the Waste Glass Powder Concrete (WGPC) exhibited an improved flexural strength with the modulus of rupture for WGPC being 2% higher than control concrete at the age of 84 days. Based on the results of this study it was concluded that 25% replacement of cement with WGP provides an optimum replacement ratio. Doi: 10.28991/cej-2020-03091620 Full Text: PDF
Edukasi Budi Daya Ikan Lele Kolam Terpal di Panti Asuhan Nurul Ikhsan Merawang Kabupaten Bangka
Authors: Pratiwi Fika Dewi , Atmadja Eddy Jajang Jaya , Astuti Rufti Puji 
Published: November 2020

Growing catfish is relative needs a short time (3-4 months) that can be profitable for cultivators. The increase of public demand for catfish provides an opportunity for everyone to carry out this business, including the orphanage students. Because of this, the orphan empowerment aimed to educate and practice the basics of conventional catfish farming used probio-Fm technology. The program was conducted in November-December 2018. The empowerment program location was at Nurul Ikhsan Orphanage, Batu Rusa village, Merawang District, Bangka Regency, Bangka Belitung Islands Province. The participants were 40 orphans. Four steps of the program consisted of 1) preparation (coordination, survey, and materials preparation), 2) discussion of the training materials (management of conventional catfish farming) 3) Field practice (demonstration of plastic fish tank design and application of probio-Fm) 4) Monitoring and evaluation (the distribution of the questionnaire). Based on the questionnaire, the average of participants (50 %) agreed if they categorized as motivated participants in the program, the Transfering theory and practice methods were easy to understand and follow their needs. Besides, they agreed on the continuity of the program. We concluded that the program succeeded in educating the orphan student about cultivating the catfish with the conventional method based on probio-Fm, however, catfish maintenance should be accompanied by the intensive assistance until harvest. Educating catfish business analysis could more motivate the orphanage student to practice catfish farming.
Pendeteksian Penjiplakan Kode Program C dengan Menggunakan Algoritme K-Medoids
Authors: Sitanggang Imas Sukaesih , Hakim Raden Fityan 
Published: November 2020

Pada era globalisasi ini, aksi penjiplakan lebih sering dan lebih mudah dilakukan, termasuk penjiplakan terhadap kode program. Pendeteksian manual terhadap aksi penjiplakan memakan banyak waktu maupun tenaga. Oleh karena itu, dibutuhkan sistem yang dapat membantu proses pendeteksian. Pendeteksian dapat dilakukan dengan mengelompokkan kode-kode program yang mirip berdasarkan struktur kode program. Penelitian ini bertujuan untuk menerapkan algoritme K-Medoids pada 4 buah dataset kode program C dan menganalisis hasil pengelompokan yang diperoleh. Hasil percobaan menunjukkan bahwa clustering terbaik pada dataset 1 (Kondisi If-Else dan Pengulangan While) diperoleh pada k (jumlah cluster) 10 dengan rataan dissimilarity 2.655, dimana 18.9% tugas mahasiswa memiliki kelompok yang sama. Pada dataset 2 (Pengulangan While), clustering terbaik diperoleh pada k = 9 dengan rataan dissimilarity 2.227, dimana 32.6% tugas mahasiswa memiliki kelompok yang sama. Untuk dataset 3 (Pengulangan For Bersarang dan Kondisi If), tugas mahasiswa terbagi menjadi dua buah cluster dengan rataan dissimilarity 0.719, dimana 87% tugas mahasiswa berada pada cluster yang sama. Hasil clustering terbaik pada dataset 4 (Kondisi If-Else dan Pengulangan For) diperoleh pada k = 6 dengan rataan dissimilarity 3.199, dimana 61% tugas mahasiswa berada pada kelompok yang sama.
Kata Kunci: clustering, K-medoids, N-gram, pendeteksian penjiplakan, program C.
Pengembangan Aplikasi Android E-Initiative Patriot Pangan sebagai Platform Crowdfunding Kebutuhan Balita Menggunakan REST API
Authors: Syach Ryan Azrian , Ramadhan Dean Apriana 
Published: November 2020

Masa balita merupakan masa keemasan dalam seorang anak. Saat ini angka balita kekurangan gizi mencapai 17.8%. Jumlah penduduk Indonesia mencapai 261.9 Juta jiwa. Dengan tingginya jumlah penduduk Indonesia sehingga memungkinkan untuk berkolaborasi dalam membantu menekan angka kekurangan gizi. Jika masyarakat bersama-sama memberikan bantuan pangan kepada balita kekurangan gizi maka akan membantu menekan angka kekurangan gizi. Memberikan bantuan secara bersama-sama disebut crowdfunding. Crowdfunding umumnya disediakan dalam bentuk platform sebagai tempat bertemunya pendonor dan pemilik proyek. Maka dari itu penelitian ini dilakukan untuk mengembangkan aplikasi crowdfunding kebutuhan balita dalam bentuk mobile apps. Pengembangan dilakukan menggunakan metode Scrum dengan jumlah sprint sejumlah 5 sprint. Pengembangan menggunakan REST API sebagai antarmuka untuk komunikasi data antara server dan mobile apps. Penelitian ini mengembangkan aplikasi dalam bentuk Android. Seluruh masyarakat dapat menggunakan aplikasi ini. Jumlah product backlog yang dikerjakan pada penelitian ini adalah 19 items. Penelitian ini berhasil mengembangkan seluruh product backlog. Fungsi utama yang dikerjakan meliputi buat campaign, berdonasi uang/barang, dan membagikan campaign di media sosial.
Kata Kunci: Android, crowdfunding, gizi, mobile apps, REST API.