bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tectonic Influences on Trench Slope Basin Development via Structural Restoration Along the Outer Nankai Accretionary Prism, Southwest Japan
Authors: Lackey J. K. , Regalla C. A. , Moore G. F. 
Published: August 2020

AbstractThree‐dimensional (3‐D) seismic reflection data and sediment cores record ~2.87 million years of structural and depositional history of a trench slope basin along the outer Nankai accretionary prism, southwest Japan. Numerous mass transport deposits (MTDs) and fault structures are present in the basin. Here, we investigate the links between slope failures, slope basin development, and movement along a prominent out‐of‐sequence thrust (OOST) fault and development of a large anticline. Three two‐dimensional (2‐D) cross sections are restored to ~2.2 Ma using stratigraphic and structural relationships interpreted in the 3‐D data. The restorations are then compared and combined to provide a 3‐D perspective of basin development. We find that total shortening across all faults and folds was accommodated by different displacement styles along multiple branches, with 5.3, 5.5, and 7.3 km of shortening from northeast to southwest over the past ~2.2 Ma. We believe that the majority of this displacement occurred prior to ~1.7 Ma, followed by a dramatic decrease in slip rate within the study area as slip was transferred to the more seaward portions of the prism. In the northeast, deformation is primarily accommodated by the main branch of the OOST and anticlinal faulting, while deformation in the southwest is primarily along deeper branches of the OOST. This differential motion explains the occurrences of various mass wasting events, and lateral differences in trench slope basin geometry within the study area.
Variability of the South Pacific Western Subtropical Mode Water and Its Relationship With ENSO During the Argo Period
Authors: Qi Jifeng , Qu Tangdong , Yin Baoshu , Chi Jianwei 
Published: August 2020

AbstractThis study investigates variability of the South Pacific western subtropical mode water (SPWSTMW), its physical processes, and relationship with El Niño‐Southern Oscillation (ENSO), using a gridded Argo data product from January 2004 to September 2019. On seasonal timescale, the SPWSTMW volume shows a significant variability, which involves three periods: the formation period (June–October), the isolation period (November–February), and the dissipation period (March–May). This seasonal variability is related to seasonal fluctuation of the mixed layer depth. During the Argo period from 2004 to 2019, interannual variability of the SPWSTMW volume is tightly linked to the ENSO, increasing during El Niño periods and decreasing during La Niña periods. Further analyses indicate that ENSO‐related anomalous winds are primarily responsible for interannual variability of the SPWSTMW volume. The anomalous winds first influence the surface heat flux through evaporation and then the mixed layer depth through convection, leaving an imprint of ENSO on the SPWSTMW. This study also shows that the SPWSTMW responds differently to the central Pacific (CP) El Niño and eastern Pacific (EP) El Niño.
Observed Triple Mode of Salinity Variability in the Thermocline of Tropical Pacific Ocean
Authors: Hu Shijian , Sprintall Janet , Guan Cong , Hu Dunxin , Wang Fan , Lu Xi , Li Shihan 
Published: August 2020

AbstractA well‐defined Triple MOde of Salinity (TMOS) variability in the tropical Pacific thermocline layer (24–25.5 σθ isopycnal surfaces) is revealed from the Argo observations during 2004–2018. Thermocline salinity in the tropical northern and southwestern Pacific Ocean varies out of phase on interannual to near‐decadal time scales with that in the tropical southeastern Pacific Ocean. The TMOS is attributed to anomalous advection of mean salinity as well as advection of anomalous salinity by the mean oceanic current on isopycnal surfaces. While the TMOS pattern is quite different from the thermal patterns associated with the El Niño‐Southern Oscillation (ENSO) or the Pacific Decadal Oscillation (PDO), it is significantly associated with the ENSO and PDO indices with a time lag of 10 months. Isopycnal propagation of salinity anomalies and anomalous freshwater input in the outcropping region, also both associated with ENSO and PDO, are important in the formation of TMOS. The propagation speed of isopycnal salinity anomalies is close to documented phase speeds of baroclinic Rossby waves and velocities of zonal currents. The TMOS acts to shape the basin‐scale Pacific water masses and potentially plays an important role in climate.
Drivers of Subsurface Temperature Variability in the Northern California Current
Authors: Ray S. , Siedlecki S. A. , Alexander M. A. , Bond N. A. , Hermann A. J. 
Published: August 2020

AbstractJISAO's Seasonal Coastal Ocean Prediction of the Ecosystem (J‐SCOPE) was developed to carry out experimental seasonal forecasts of ocean conditions in the Northern California Coastal System (N‐CCS). This system relies on NOAA's Coupled Forecast System (CFS) global climate model to provide initial and boundary conditions for dynamical downscaling with a high‐resolution numerical ocean model. Experiments with J‐SCOPE show that the bottom temperature on the shelf is more predictable than the sea surface temperature (SST) on seasonal time scales. While seasonal forecasts have been shown to have positive skill in terms of SST for the CCS due to El Niño‐Southern Oscillation (ENSO), the mechanism(s) responsible for subsurface predictability in the N‐CCS have yet to be determined. This study quantifies the relative importance of North Pacific and Tropical Pacific properties in determining the variations in temperatures at depth (TDs) on the N‐CCS shelf. A multivariable linear regression (MLR) model with selected predictors explains almost 83% of the N‐CCS TD variability with oceanic teleconnections from the North Pacific dominating the variance. The N‐CCS TD is related to (i) coastally trapped waves (CTWs) related to ENSO, originating in Tropical Pacific, (ii) west‐central Pacific spice anomalies, (iii) seasonal Pacific Decadal Oscillation (PDO) variation, and a more local influence from (iv) anomalies south of N‐CCS, originating in North Pacific. ENSO and CTW can each impact the depth of the California Undercurrent (CUC) core with the latter most prominently following ENSO events. The results on potential sources of predictability are relevant to the continued development of current seasonal forecasting efforts off the U.S. West coast.
Laboratory Investigation of Particle‐Scale Factors Affecting the Settling Velocity of Volcaniclastic Dust
Authors: Richards‐Thomas Tamar , McKenna‐Neuman Cheryl 
Published: August 2020

AbstractIceland contains some of the largest and most active dust sources in the Arctic, with the frequency of major emission events increasing in the wake of catastrophic volcanic eruptions, such as the 2010 Eyjafjallajökull eruption. Relatively juvenile Icelandic volcaniclastic dust particles are porous and highly angular, and they frequently bear ultrafine nanoscale dustcoats. Their low density is speculated to affect deposition rates in the atmosphere, while substantial amounts of water adsorbed onto their expansive surface area may affect nucleation, aggregation, and settling. Using a 2‐D laser Doppler anemometer, the present paper reports on a set of highly controlled fall column experiments designed to evaluate the dependency of the settling velocity upon particle morphology (e.g., size, shape, density, and surface area) and relative humidity (RH). Measurements for samples obtained from four Icelandic field sites are compared to those for solid glass spheres of similar diameter. The results confirm that the amount of adsorbed water increases with RH and the particle specific surface area. Higher dust concentrations are found to favor particle interaction and the formation of aggregates, especially at higher RH. Under dry conditions (20 % < RH < 30 % ), the horizontal drift velocity measured for the angular, porous Icelandic particles exceeds that observed for solid glass spheres, although these measurements are an order of magnitude smaller than the vertical velocity. As compared to particle diameter, shape does not appear to influence either the settling rate or drag coefficient at Reynolds numbers ≤10−2, owing to the dominance of viscous effects over form drag.
Climatology of Dust‐Forced Radiative Heating Over the Tibetan Plateau and Its Surroundings
Authors: Wang Tianhe , Han Ying , Huang Jianping , Sun Mengxian , Jian Bida , Huang Zhongwei , Yan Hongru 
Published: August 2020

AbstractDust aerosol can affect the atmospheric thermal structure and exert great melting potential on snow and ice sheets. In this study, the decadal climatology of dust‐forced radiative heating (DRH) in the atmosphere over Tibetan Plateau and its surroundings (TPS) was investigated using the Santa Barbara DISORT Atmospheric Radiative Transfer (SBDART) model along with the CALIPSO satellite observations from 2007 to 2016. After screening out other aerosols, the vertical distribution of dust aerosol was examined to accurately assess the DRH. The net DRH showed a significant warm effect mainly by dust loading, which covers from the center of dust sources to their adjacent transport regions. The maximum value of the DRH appeared at the near‐surface, while the DRH decreased with an increase in height. The climatic average DRH at the near‐surface reached 16.8 K/month at the Taklimakan Desert (TD) and 10.8 K/month at the Gangetic Plain in spring, 13.7 K/month at the Indus Plain in summer, which is 3–3.6 times warmer than the column‐averaged DRHs. This study also found the most significant influence of dust events on the Qaidam Basin in the TPS, in which the near‐surface DRH was 4.7 K/month during spring. It is also noteworthy that the intermonth and interannual variations of the DRH highlighted the significant warming effect of dust aerosols on the atmospheric thermal structure, especially at the near‐surface. In addition, we need to pay more attention to changes in snow‐related processes influenced by absorbing aerosols and the light‐absorbing impurities deposited in snow over the TPS.
Unified Entrainment and Detrainment Closures for Extended Eddy‐Diffusivity Mass‐Flux Schemes
Authors: Cohen Yair , Lopez‐Gomez Ignacio , Jaruga Anna , He Jia , Kaul Colleen M. , Schneider Tapio 
Published: August 2020

AbstractWe demonstrate that an extended eddy‐diffusivity mass‐flux (EDMF) scheme can be used as a unified parameterization of subgrid‐scale turbulence and convection across a range of dynamical regimes, from dry convective boundary layers, through shallow convection, to deep convection. Central to achieving this unified representation of subgrid‐scale motions are entrainment and detrainment closures. We model entrainment and detrainment rates as a combination of turbulent and dynamical processes. Turbulent entrainment/detrainment is represented as downgradient diffusion between plumes and their environment. Dynamical entrainment/detrainment is proportional to a ratio of a relative buoyancy of a plume and a vertical velocity scale, that is modulated by heuristic nondimensional functions which represent their relative magnitudes and the enhanced detrainment due to evaporation from clouds in drier environment. We first evaluate the closures offline against entrainment and detrainment rates diagnosed from large‐eddy simulations (LES) in which tracers are used to identify plumes, their turbulent environment, and mass and tracer exchanges between them. The LES are of canonical test cases of a dry convective boundary layer, shallow convection, and deep convection, thus spanning a broad range of regimes. We then compare the LES with the full EDMF scheme, including the new closures, in a single column model (SCM). The results show good agreement between the SCM and LES in quantities that are key for climate models, including thermodynamic profiles, cloud liquid water profiles, and profiles of higher moments of turbulent statistics. The SCM also captures well the diurnal cycle of convection and the onset of precipitation.
Ultrafast hydrogen bond dynamics of liquid water revealed by terahertz-induced transient birefringence
Authors: Zhao Hang , Tan Yong , Zhang Liangliang , Zhang Rui , Shalaby Mostafa , Zhang Cunlin , Zhao Yuejin , Zhang Xi-Cheng 
Published: August 2020

AbstractThe fundamental properties of water molecules, such as their molecular polarizability, have not yet been clarified. The hydrogen bond network is generally considered to play an important role in the thermodynamic properties of water. The terahertz (THz) Kerr effect technique, as a novel tool, is expected to be useful in exploring the low-frequency molecular dynamics of liquid water. Here, we use an intense and ultrabroadband THz pulse (peak electric field strength of 14.9 MV/cm, centre frequency of 3.9 THz, and bandwidth of 1–10 THz) to resonantly excite intermolecular modes of liquid water. Bipolar THz field-induced transient birefringence signals are observed in a free-flowing water film. We propose a hydrogen bond harmonic oscillator model associated with the dielectric susceptibility and combine it with the Lorentz dynamic equation to investigate the intermolecular structure and dynamics of liquid water. We mainly decompose the bipolar signals into a positive signal caused by hydrogen bond stretching vibration and a negative signal caused by hydrogen bond bending vibration, indicating that the polarizability perturbation of water presents competing contributions under bending and stretching conditions. A Kerr coefficient equation related to the intermolecular modes of water is established. The ultrafast intermolecular hydrogen bond dynamics of water revealed by an ultrabroadband THz pump pulse can provide further insights into the transient structure of liquid water corresponding to the pertinent modes.
Longitudinal trajectories of adiposity-related measures from age 2–5 years in a population of low-income Hispanic children
Authors: Crespi Catherine M. , Gao Shuang , Payne Alexandra , Nobari Tabashir Z. , Avila Analissa , Nau Claudia , Whaley Shannon E. , Wang May C. 
Published: August 2020

Abstract
Background
We estimated longitudinal trajectories of body mass index (BMI) z-score and percentile, weight for height (WFH) z-score and percentile, and percentage of the 95th BMI percentile (BMIp95) among low-income Hispanic children ages 2–5 years to provide normative data for this population and compare the behavior of different measures.

Methods
Longitudinal height and weight measurements obtained from 18,072 Hispanic children aged 2–5 years enrolled in the Special Supplemental Nutrition Program for Women, Infants and Children in Los Angeles County were analyzed. Trajectories of adiposity-related measures were estimated using mixed models, stratified by sex and BMI percentile at age 2 years.

Results
For children in the 5th–85th BMI percentile at age 2 years, all adiposity-related measures rose during ages 2–3.5 years; during ages 3.5–5 years, BMI-based measures increased, BMIp95 decreased, and WFH-based measures were stable. For children exceeding the 85th BMI percentile at age 2 years, measures generally trended downward during ages 2–5 years, except for BMIp95, which had variable trends.

Conclusions
Adiposity measures changed at different rates as children grew during ages 2–3.5 years compared to ages 3.5–5 years, and different measures displayed different trends. Studies should consider examining multiple measures and focusing on change relative to a comparison group.

Impact

To address the childhood obesity epidemic, information on normative trajectories of adiposity-related measures in at-risk populations of young children is needed.

Longitudinal analysis of data collected from low-income Hispanic children during ages 2–5 years revealed different patterns for different adiposity measures and for ages 2–3.5 years versus 3.5–5 years.

Child obesity studies should consider examining multiple adiposity measures and focus on change relative to a comparison group to avoid misinterpreting longitudinal patterns.
Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders
Authors: Kuan Pei-Fen , Clouston Sean , Yang Xiaohua , Kotov Roman , Bromet Evelyn , Luft Benjamin J. 
Published: August 2020

AbstractExisting work on proteomics has found common biomarkers that are altered in individuals with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current study expands our understanding of these biomarkers by profiling 276 plasma proteins with known involvement in neurobiological processes using the Olink Proseek Multiplex Platform in individuals with both PTSD and MCI compared to either disorder alone and with unaffected controls. Participants were World Trade Center (WTC) responders recruited through the Stony Brook WTC Health Program. PTSD and MCI were measured with the PTSD Checklist (PCL) and the Montreal Cognitive Assessment, respectively. Compared with unaffected controls, we identified 16 proteins associated with comorbid PTSD–MCI atP < 0.05 (six at FDR < 0.1), 20 proteins associated with PTSD only (two at FDR < 0.1), and 24 proteins associated with MCI only (one at FDR < 0.1), for a total of 50 proteins. The multiprotein composite score achieved AUCs of 0.84, 0.77, and 0.83 for PTSD–MCI, PTSD only, and MCI only versus unaffected controls, respectively. To our knowledge, the current study is the largest to profile a large set of proteins involved in neurobiological processes. The significant associations across the three case-group analyses suggest that shared biological mechanisms may be involved in the two disorders. If findings from the multiprotein composite score are replicated in independent samples, it has the potential to add a new tool to help classify both PTSD and MCI.
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
Authors: Srivastava Mayank , Zhang Ying , Chen Jian , Sirohi Devika , Miller Andrew , Zhang Yang , Chen Zhilu , Lu Haojie , Xu Jianqing , Kuhn Richard J. , Andy Tao W. 
Published: August 2020

AbstractThe outbreak of Zika virus (ZIKV) in 2016 created worldwide health emergency which demand urgent research efforts on understanding the virus biology and developing therapeutic strategies. Here, we present a time-resolved chemical proteomic strategy to track the early-stage entry of ZIKV into host cells. ZIKV was labeled on its surface with a chemical probe, which carries a photocrosslinker to covalently link virus-interacting proteins in living cells on UV exposure at different time points, and a biotin tag for subsequent enrichment and mass spectrometric identification of the receptor or other host proteins critical for virus internalization. We identified Neural Cell Adhesion Molecule (NCAM1) as a potential ZIKV receptor and further validated it through overexpression, knockout, and inhibition of NCAM1 in Vero cells and human glioblastoma cells U-251 MG. Collectively, the strategy can serve as a universal tool to map virus entry pathways and uncover key interacting proteins.
Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity
Authors: Müller Helena , Fehling Sarah Katharina , Dorna Jens , Urbanowicz Richard A. , Oestereich Lisa , Krebs Yvonne , Kolesnikova Larissa , Schauflinger Martin , Krähling Verena , Magassouba N’Faly , Fichet-Calvet Elisabeth , Ball Jonathan K. , Kaufmann Andreas , Bauer Stefan , Becker Stephan , von Messling Veronika , Strecker Thomas 
Published: August 2020

AbstractLassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against LASV have obtained regulatory approval. Polyclonal neutralizing antibodies derived from hyperimmunized animals may offer a useful strategy for prophylactic and therapeutic intervention to combat human LASV infections. The LASV envelope surface glycoprotein complex (GP) is the major target for neutralizing antibodies, and it is the main viral antigen used for the design of an LASV vaccine. Here, we assessed the immunogenic potential of mammalian cell-derived virus-like particles (VLPs) expressing GP from the prototypic LASV strain Josiah in a native-like conformation as the sole viral antigen. We demonstrate that an adjuvanted prime-boost immunization regimen with GP-derived VLPs elicited neutralizing antibody responses in rabbits, suggesting that effective antigenic epitopes of GP were displayed. Notably, these antibodies exhibited broad reactivity across five genetic lineages of LASV. VLP-based immunization strategies may represent a powerful approach for generating polyclonal sera containing cross-reactive neutralizing antibodies against LASV.
Alk1 haploinsufficiency causes glomerular dysfunction and microalbuminuria in diabetic mice
Authors: Lora Gil Cindy , Henley Nathalie , Leblond François A. , Akla Naoufal , Laurin Louis-Philippe , Royal Virginie , Gerarduzzi Casimiro , Pichette Vincent , Larrivée Bruno 
Published: August 2020

AbstractEndothelial dysfunction has been shown to play an important role in the pathogenesis of glomerular damage during diabetic kidney disease (DKD). As such, a better understanding of the molecular mechanisms involved in glomerular endothelial dysfunctions could provide novel therapeutic strategies for the prevention of DKD. We have previously shown that Alk1/BMP9 signaling plays an important function to maintain vascular integrity in diabetic animals. As such, we evaluated the effects of Alk1 suppression on glomerular endothelial function in diabetic mice. In the present study, we used mice with conditional heterozygote deletion of Alk1 in the endothelium (Alk1ΔEC) to evaluate the role of Alk1 on kidney function during STZ-induced diabetes. DKD was investigated in diabetic control and Alk1ΔEC mice euthanized eight weeks after the onset of diabetes. We showed that Alk1 expression is reduced in the glomeruli of human DKD patients. While renal function was not altered in Alk1ΔEC non-diabetic mice, we showed that Alk1 haploinsufficiency in the glomerular endothelium leads to microalbuminuria, thickening of the glomerular basement membrane, glomerular apoptosis and podocyte loss in diabetic mice. These data suggest that Alk1 is important for the proper function of glomerular endothelial cells and that decreased Alk1 combined with chronic hyperglycemia can impair renal function.