bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of maternal attachment among breastfeeding mothers in Jordan
Authors: Abuhammad Sawsan 
Published: August 2020

AbstractAimThis study aims to investigate the difference in maternal attachment in different scenarios, that is among mothers who breastfed their infants and mothers who combined breastfeeding with other types of feeding and determine the predictors of maternal attachment in breastfeeding mothers.DesignA survey was used to collect data from 222 mothers from Jordan University of Science and Technology in Jordan.MethodWho used breastfeeding or mixed methods and had healthy infants aged from 3 to 12 months and who did not have postpartum complications. The survey was conducted in three healthcare centres in Irbid city, Jordan.ResultsMothers only breastfeed their infants did not differ in their attachment compared with those who used mixed feeding methods (using breastfeeding with formula feeding). Many factors showed significant impact on maternal attachment, which includes the mother's education, if they have assistance in caring for their infant, marital relationship quality, the infant's gender and the planning for pregnancy.
Working with national quality registries in older people care: A qualitative study of perceived impact on assistant nurses’ work situation
Authors: Westerlund Anna , Sparring Vibeke , Hasson Henna , Weinehall Lars , Nyström Monica E. 
Published: August 2020

AbstractAimThe aim was to investigate assistant nurses’ perceptions of how working with national quality registries affected their work situation in care of older people.DesignQualitative interview study.MethodsSixteen semi‐structured interviews were conducted at four special housing units in Sweden, and a conventional content analysis, with elements of thematic analysis, was applied.ResultsThe introduction of national quality registries contributed to role clarifications and the development of new formal work procedures in terms of documentation and arenas and routines for communication. The increased systematics and effectiveness gained from these changes had a perceived positive effect on the work situation, workload, work satisfaction, staff interactions and learning and reflection.
Investigation of toughening effect of biomass‐derived SiCB on basalt fiber‐reinforced unsaturated polyester composites
Authors: Yu Kaifeng , He Xiaoling , Li Yi , Liang Ce 
Published: August 2020

AbstractFiber‐reinforced polymer composites are outstanding lightweight structural materials, so that they are widely used in automotive, marine, medical, defense, and aerospace fields. However, when subjected to structural loads, they are prone to failure due to their inherent brittleness and the susceptibility to delamination, which can lead to the loss of the load‐bearing capacity of composite materials. This article proposes an effective solution of innovatively using the silicon carbon black, a kind of sustainable green biomass material derived from rice husks, to toughen the composites. When the content of silicon carbon black (SiCB) added to the composites is 1.5 wt%, the maximum values of flexural strength, bending energy absorption, and the mode II interlaminar fracture toughness values are 333 MPa, 6.10 J, and 1591 J/m2, respectively, corresponding to the improvement percentage of 138%, 120%, and 216%. The addition of SiCB significantly improved the bending properties and the mode II interlaminar fracture toughness of composites. The toughening mechanisms of SiCB were studied based on the fracture surface morphologies of the composites.
Treprostinil Attains Clinically Therapeutic Concentrations in Neonates with Pulmonary Hypertension on Extracorporeal Membrane Oxygenation Support
Authors: De Bie Felix R. , Allegaert Karel , Hedrick Holly L. , Rintoul Natalie E. , Davidson Alexander 
Published: August 2020

Background: Treprostinil is a prostacyclin analog used for treatment of pulmonary hypertension (PH) in adults and children, currently awaiting clinical assessment for use in neonates.Objectives: We aimed to investigate the use of treprostinil in neonates with PH on extracorporeal membrane oxygenation (ECMO) support and measure plasma concentrations of the drug.Methods: This is a retrospective case‐series with prospectively collected blood samples, conducted in a quaternary care neonatal intensive care unit. Brain natriuretic peptide, cardiac function on Doppler echocardiography, and the occurrence of adverse effects was monitored. Plasma concentrations were measured using high‐performance liquid chromatography and mass spectrometry.Results: Four patients with PH requiring ECMO therapy were studied. Treprostinil doses of 20–58 ng/kg/min reached concentrations of 0.99–4.39 ng/ml and induced clinical improvement. Infusion of treprostinil was associated with improved right ventricular function, reversed right‐to‐left shunting through the ductus arteriosus, and stable or decreasing need for vasopressor support. No adverse effects were observed.Conclusions: This is the first study to report clinically therapeutic treprostinil concentrations in circulating plasma after treprostinil administration in neonates on ECMO, with associated clinical improvement of PH and no signs of hemodynamic instability.
DeepRescore: Leveraging Deep Learning to Improve Peptide Identification in Immunopeptidomics
Authors: Li Kai , Jain Antrix , Malovannaya Anna , Wen Bo , Zhang Bing 
Published: August 2020

AbstractThe identification of major histocompatibility complex (MHC)‐binding peptides in mass spectrometry (MS)‐based immunopeptideomics relies largely on database search engines developed for proteomics data analysis. However, because immunopeptidomics experiments do not involve enzymatic digestion at specific residues, an inflated search space leads to a high false positive rate and low sensitivity in peptide identification. In order to improve the sensitivity and reliability of peptide identification, a post‐processing tool named DeepRescore is developed. DeepRescore combines peptide features derived from deep learning predictions, namely accurate retention timeand MS/MS spectra predictions, with previously used features to rescore peptide‐spectrum matches. Using two public immunopeptidomics datasets, it is shown that rescoring by DeepRescore increases both the sensitivity and reliability of MHC‐binding peptide and neoantigen identifications compared to existing methods. It is also shown that the performance improvement is, to a large extent, driven by the deep learning‐derived features. DeepRescore is developed using NextFlow and Docker and is available at https://github.com/bzhanglab/DeepRescore.
Global Lysine Crotonylation Profiling of Mouse Liver
Authors: Liu Jiang‐Feng , Wu Song‐Feng , Liu Shu , Sun Xin , Wang Xiao‐Man , Xu Ping , Chen Hou‐Zao , Yang Jun‐Tao 
Published: August 2020

AbstractLysine crotonylation (Kcr) is a recently discovered post‐translational modification that potentially regulates multiple biological processes. With an objective to expand the available crotonylation datasets, LC‐MS/MS is performed using mouse liver samples under normal physiological conditions to obtain in vivo crotonylome. A label‐free strategy is used and 10 034 Class I (localization probabilities > 0.75) crotonylated sites are identified in 2245 proteins. The KcrE, KcrD, and EKcr motifs are significantly enriched in the crotonylated peptides. The identified crotonylated proteins are mostly enzymes and primarily located in the cytoplasm and nucleus. Functional enrichment analysis based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes shows that the crotonylated proteins are closely related to the purine‐containing compound metabolic process, ribose phosphate metabolic process, carbon metabolism pathway, ribosome pathway, and a series of metabolism‐associated biological processes. To the best of the authors' knowledge, this research provides the first report on the mouse liver crotonylome. Furthermore, it offers additional evidence that crotonylation exists in non‐histone proteins, and is likely involved in various biological processes. The mass spectrometry proteomics data have been deposited in the ProteomeXchange Consortium with the dataset identifiers PXD019145.
Two phase I/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells
Authors: Garcia-Arranz Mariano , Alonso-Gregorio Sergio , Fontana-Portella Pamela , Bravo Elena , Diez Sebastian Jesus , Fernandez-Santos María Eugenia , Garcia-Olmo Damian 
Published: August 2020

Abstract
We evaluated the safety and feasibility of adipose-derived mesenchymal stem cells to treat endoscopically urinary incontinence after radical prostatectomy in men or female stress urinary. We designed two prospective, nonrandomized phase I-IIa clinical trials of urinary incontinence involving 9 men (8 treated) and 10 women to test the feasibility and safety of autologous mesenchymal stem cells for this use. Cells were obtained from liposuction containing 150 to 200 g of fat performed on every patient. After 4 to 6 weeks and under sedation, endoscopic intraurethral injection of the cells was performed. On each visit (baseline, 1, 3, 6, and 12 months), clinical parameters were measured, and blood samples, urine culture, and uroflowmetry were performed. Every patient underwent an urethrocystoscopy and urodynamic studies on the first and last visit. Data from pad test, quality-of-life and incontinence questionnaires, and pads used per day were collected at every visit. Statistical analysis was done by Wilcoxon signed-rank test. No adverse effects were observed. Three men (37.5%) and five women (50%) showed an objective improvement of &gt;50% (P &lt; .05) and a subjective improvement of 70% to 80% from baseline. In conclusion, intraurethral application of stem cells derived from adipose tissue is a safe and feasible procedure to treat urinary incontinence after radical prostatectomy or in female stress urinary incontinence. A statistically significant difference was obtained for pad-test improvement in 3/8 men and 5/10 women. Our results encourage studies to confirm safety and to analyze efficacy.

Lessons learned • This safety clinical trial made use of mesenchymal stem cells for the treatment of urinary incontinence.• Intraurethral application of stem cells derived from adipose tissue is a safe and feasible procedure to treat urinary incontinence. Significance statementThis article reports the results of two clinical trials that studied safety of the treatment of urinary incontinence in men and women through the use of mesenchymal stem cells derived from adipose tissue obtained from the patient or cultured ex vivo.
Supramolecular Self‐Assembly Properties of Metallo‐Ionic Phthalocyanines Constituting Regioisomers
Authors: Inchara Seegepalli Anandamurthy , Veerabhadraswamy Bhyranalyar Nagarajappa , Paul Bishwajit , Hegde Gurumurthy , Yelamaggad Channabasaveshwar Veerappa , Shanker Govindaswamy 
Published: August 2020

AbstractWe describe the synthesis and properties of metallo‐ionic phthalocyanines (MIPCs), obtained upon interacting metalled phthalocyaninetetracarboxylic acid with 1‐ethyl‐3‐methyl imidazolium chloride in a methanolic sodium hydroxide (NaOH) condition. Two MIPCs analyzed by 1H‐NMR and MALDI‐TOF, additionally, the four positional regioisomers (Cs, C4h, D2hand C2v) confirm by High Performance Liquid Chromatography (HPLC) analysis indicate the purity of the sample. The UV‐visible and photoluminescence spectroscopy used to characterize the effects of peripheral substituents on the absorption and emission spectroscopy that featured the distinctive J(Jelly) and H(hypsochromic) aggregates of MIPCs in a polar solvent. Electrochemical characteristics evaluated through cyclic voltammetry (CV) confirms the redox properties and the electron transfer mechanism studied by DFT calculations. Gelation experiment demonstrated on zinc‐ionic phthalocyanine shows the entangled network as evaluated using Scanning Electron Microscopy (SEM) images. We also studied the chromonic liquid crystalline behavior of MIPCs.
Heteroatom Promoted Ni/Al2O3 Catalysts for Highly Efficient Hydrogenation of 1,4‐Butynediol to 1,4‐Butenediol
Authors: Wu Hongli , Ma Fengyun , Wang Yuelan , Zeng Yan , Wu Hao , Yin Shuangjie , Mian Inamullah , Tsubaki Noritatsu 
Published: August 2020

AbstractA series of nickel‐based catalysts were prepared by solution combustion synthesis (SCS), using Ce, Ag, Mo, Fe, or Co as a promoter, and applied for efficient and selective hydrogenation of 1,4‐butynediol (BYD) to 1,4‐butenediol (BED). It was found that each catalyst containing promoter had higher conversion of BYD and higher selectivity of BED than that of pristine Ni/Al2O3 catalyst. Among as‐prepared catalysts, Ni−Fe/Al2O3 exhibited the highest activity and stability toward selective hydrogenation of BYD to BED. Results revealed that the improved catalytic performance of Ni−Fe/Al2O3 over those of Ni/Al2O3 could be ascribed to the varied metal‐support interaction and active site dispersion, as well as the formation of Ni−Fe taenite. DFT calculations further demonstrated that the introduction of Fe regulated the adsorption strength of BYD and H on the surface of the catalyst, thus improving the catalytic hydrogenation activity of BYD.
Adenine Derivatives for Regenerable Antibacterial Surface Applications Based on A−T Base Pairing
Authors: Kinali‐Demirci Selin , Idil Onder , Disli Ali , Demirci Serkan 
Published: August 2020

AbstractSurface contamination is a major concern in the design, fabrication, and application of biomaterials. In this work, a series of new adenine derivatives were synthesized in a three‐step method with the goal of protecting the functional materials against microbial adhesion. Initially, 9‐(chloroalkyl)‐9H‐purin‐6‐amine compounds were synthesized from adenine. Then, these compounds were reacted with potassium thiocyanate or potassium selenocyanate. In the last step, adenine derivatives incorporating a tetrazole ring were synthesized via the cycloaddition of sodium azide with thiocyano or selenocyano derivatives. The antimicrobial activity of the compounds was evaluated by using the minimal inhibitory concentration method. Furthermore, the effect of the compounds on pBR322 plasmid DNA was studied using gel electrophoretic mobility measurements. The antimicrobial assay showed that some of the synthesized compounds exerted vigorous antibacterial and antifungal activities. Further experiments indicated that seleno‐adenine derivatives have higher antimicrobial and DNA effect than other derivatives. The surfaces activated by the adenine derivative demonstrated antibacterial activity resisting bacterial attachment in order to remove dead bacteria from the surface. All results showed that some of these adenine derivatives have an antibacterial activity and the potential for further applications, for example as a smart surface coating that prevents bacterial adhesion to biomaterials.
Improving the Performance of PANI‐SA⋅TiO2Supercapacitor Active Electrode MaterialviaEmulsion Polymerization of Aniline with MWCNT
Authors: Gottam Ramesh , Srinivasan Palaniappan , Keloth Basavaiah 
Published: August 2020

AbstractFlexible electrode with high electrical conductivity and electrochemical performance are desirable today to meet the energy demand in portable electronics. Here we designed a flexible electrode, polyaniline‐sulfate‐titanium dioxide‐multiwalled carbon nanotubes (PANI‐SA⋅TiO2⋅MWCNT) to improve the electrochemical performance. This is achieved by following a synthetic strategy via the synthesis of PANI‐SA⋅TiO2⋅MWCNT by a two‐step process; initially, PANI‐SA⋅TiO2synthesized by aqueous polymerization using two oxidants, namely peroxotitanium acid (PTiA) and ammonium persulfate (APS). Wherein, PTiA acts both as oxidant and source of TiO2. In the second step, emulsion polymerization of PANI‐SA⋅TiO2with a small amount of MWCNT by benzoyl peroxide as oxidant. Formed PANI‐SA⋅TiO2⋅MWCNT was coated on a stainless steel foil without using any binder. Electrochemical performances of the electrodes of both PANI‐SA⋅TiO2and PANI‐SA⋅TiO2⋅MWCNT were carried in symmetric cell supercapacitor configuration in aq. 1 M sulfuric acid electrolyte by cyclic voltammetry and charge‐discharge measurements. This composite exhibits an excellent rate capability, and no degradation was observed in specific capacitance over 5,000 charge‐discharge cycles carried even at a higher current density of 1.6 A g−1. The electrochemical performance of PANI‐SA⋅TiO2,including cycle life, is enhanced with the use of MWCNT.
Copper‐Catalyzed [2+2+1+1] Annulation for the Regioselective Synthesis of 2,6‐Diarylpyridines via C1‐Insertion and Subsequent Cyclization
Authors: Vodnala Nagaraju , Gujjarappa Raghuram , Satheesh Vanaparthi , Gupta Richa , Kaldhi Dhananjaya , Kabi Arup K. , Malakar Chandi C. 
Published: August 2020

AbstractCopper‐catalyzed [2+2+1+1] annulation strategy has been investigated for the regioselective synthesis of symmetrical and unsymmetrical 2,6‐diarylpyridines using aliphatic amines as nitrogen source and DMSO as C1‐synthon. The developed protocol was successful for the transformation of non‐activated aromatic ketones and non‐activated aliphatic amines into 2,6‐diarylpyridines via an “easy to access” approach. This protocol has been verified on wide range of substrates having various functional groups.
A curricular Delphi study to improve the science education of secondary school students in Spain
Authors: Charro Elena 
Published: August 2020

AbstractA curricular Delphi study was carried out to help improve and develop scientific training for secondary school students in Spain. Using the Delphi method, the authors analyzed the degree of consensus among more than 100 stakeholders' answers to the question, “What aspects of science education are considered desirable for a (Spanish) citizen?” From their answers, the authors identified a set of five “concepts.” Of these, the most relevant was “Science education related to environmental issues and human health, through the use of strategies based on discussion/debate and inquiry‐based science learning.” This study compares these results with those of previous studies and makes proposals for educational reform based on the implications of its findings.
Supporting middle school students’ science talk: A comparison of physical and virtual labs
Authors: Puntambekar Sadhana , Gnesdilow Dana , Dornfeld Tissenbaum Catherine , Narayanan N. Hari , Rebello N. Sanjay 
Published: August 2020

AbstractResearch exploring students’ learning from physical and virtual labs has suggested that on the whole, students learn science content just as well, if not better from virtual labs as they do from physical labs. However, the affordances of physical labs might support the learning of specific skills and competencies that are just as crucial for learning science. In this study, we examined students’ discussions as they worked on physical and virtual labs to better understand how they learned from each, and the kinds of learning that each type of lab supported. One hundred and fifteen 6th grade students from three science teachers’ classes participated in this study. We examined audio data from all available groups as they engaged in physical and virtual labs (n = 14 groups; physical, n = 8 groups; virtual, n = 6 groups). We found that students conducting physical labs engaged in a significantly higher proportion of talk related to setting up apparatus and taking measurements and calculating outputs. Students who performed virtual labs, on the other hand, engaged in significantly more discussions about making predictions and understanding patterns of relationships between variables, and interpreting science phenomena. While students in the Virtual condition engaged in discussions that were more focused on the relationships between science ideas, students in the Physical condition learned science practices related to planning and carrying out investigations that are equally valuable. Our findings suggest that learning from one experimental modality may complement and supplement the relative weaknesses of the other, indicating a need for strategically combining the two. Implications and future directions are discussed.
Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice
Authors: Alotaibi Badriyah , Tousson Ehab , El‐Masry Thanaa A. , Altwaijry Najla , Saleh Asmaa 
Published: August 2020

AbstractWhile clinical innovation has improved, cancer or malignant growth stays a genuine medical issue and has been perceived as a significant factor in mortality and morbidity. Current work aimed to define the cardiac defensive effects of curcumin nanoparticles (Cur Nps) against EAC induced cardiac toxicity, injury, and alterations in apoptosis, proliferation, and cytokines immunoreactivity. Forty female mice were aimlessly and equally divided into four groups [Gp1, Control; Gp2, Cur NPs; Gp3, Ehrlich ascites carcinoma (EAC); Gp4, Co‐treatment of EAC with Cur NPs (Cur NPs + EAC)]. Serum lactate dehydrogenase (LDH), phosphocreatine kinase (CPK), creatine kinase myoglobin (CK‐MB), alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), cholesterol, triglycerides, potassium ions, cardiac injury, P53, vascular endothelial growth factor protein (VEGF), Bax, and tumor necrosis factor alpha (TNFα) expressions were significantly elevated while sodium ions levels were significantly depleted in EAC when compared to control. Co‐treatment of EAC with Cur NPs (Cur NPs + EAC) improved these parameters as compared with EAC group. So, our results indicate that; Cur NPs induced protection to the blood and heart tissue during Ehrlich ascites carcinoma.