bluuebunny/crossref_metadata_2025_split huggingface dataset:
System Models of Risk Management in the Formation of Programs of Innovative Development of the Region
Authors: Uandykova M. K. 
Published: December 2019

Purpose:the aim of the work is to study the risks of innovative development of regions and industries, develop systemic risk management models in the formation and implementation of innovative development programs in the region.Methods:the work used general scientific methods and approaches to research, such as analysis, comparison, generalization, optimization methods. Methodological approaches of risk management models include concepts, approaches aimed at the problems of risk management in the formation and implementation of regional innovative development programs, studied in domestic and foreign literature; mathematical apparatus of dichotomous and network programming.Results:the article provides a methodological justification and description of the criteria aspects of managing such tasks, risk analysis, develops a theory of project risks of a complex of innovative development programs for regions, presents models for assessing complex risk of a program, gives a statement of the problem of risk management and the formation of multi-purpose programs taking into account complex risks, as well as limitations for financing medium-risk and high-risk programs, algorithms for solving the risk management problem by dichotomous methods and networks are presented of programming. The transition from program-targeted management to integrated (joint system use of the project and scenario approaches) was completed, which allowed us to consider them holistically, form a complex of projects–programs, apply risk management mechanisms based on qualitative assessments and propose quantitative models for managing project and program risks of a program complex.Conclusions and Relevance:the proposed approach can be used in the formation and implementation of many program-targeted documents of the state and regional level with the transition to project management, as a tool for analysis and accounting of risks.
Correlation of vitamin B12 deficiency with metformin therapy in type 2 diabetes mellitus patients
Authors: Nayyar S. B. , Dhillon Manbir Kaur , Kukreja Sahiba 
Published: December 2019

Background: Diabetes mellitus is an endocrine and metabolic disorder, characterized by hyperglycemia. Metformin is the first line pharmacotherapy recommended by ADA. It has been recognized that metformin use is associated with serum vitamin B12 deficiency. The objective of this study is to determine the prevalence of serum vitamin B12 deficiency among Indian patients with type 2 diabetes mellitus on metformin therapy compared to those who are not on metformin.Methods: Here, 90 patients of type 2 diabetes mellitus of both sexes were included in this cross-sectional study conducted from January 2018 to August 2019 in SGRDIMSR, Sri Amritsar. They were divided into two groups; Group A of 60 subjects of type 2 diabetes mellitus on metformin therapy >1 year and group B of 30 subjects of type 2 diabetes mellitus not on metformin or had stopped taking metformin 6 months back. Serum vitamin B12 levels were measured using a Chemiluminescence method. Data was statistically analysed.Results: The serum vitamin B12 levels were 190.02±90.75 pmol/l in group A (metformin users) and 586.9±243.69 pmol/l in group B (not metformin users) (p value=0.002). A significant negative correlation existed between the serum vitamin B12 and duration and dose of metformin use (r꞊ -0.676) and (r -0.855) by using Pearson’s correlation coefficient in group A.Conclusions: Metformin is associated with decrease in serum vitamin B12 levels. Annual screening of serum vitamin B12 is recommended for patients of type 2 diabetes mellitus who are on metformin therapy for longer duration and /or in higher doses.
Pszichoszomatikus tünetek gyakoriságát befolyásoló tényezők 18–90 éves nők körében
Authors: FEHÉR Piroska V. , ANNÁR Dorina , ZSÁKAI Annamária , BODZSÁR Éva B. 
Published: December 2019

Psychosomatic health complaints are common in children and adults as well, and affect the quality of later life. Age tendency of psychosomatic complaints are influenced by regional, socioeconomic, environmental and lifestyle factors. Our aims were to reveal the age pattern of the psychosomatic health complaints in Hungarian women aged 18–90 years and to identify those components of lifestyle, body structure and environmental factors that affect the pattern of psychosomatic complaints among 18–90 year-old women.
Healthy premenopausal and postmenopausal women were enrolled to the present analysis (n=483). Three groups of the psychosomatic health complaints were used: somatic (abdominal pain, headache, dizziness), psychic (irritability, nervousness, grumpiness) and sleep disorders (awakenings during the night, falling asleep difficulties, waking up tired). Frequency distributions of women experiencing somatic, psychic complaints and sleep disorders often (daily or several times a week) were analysed by comparing the results derived from our previous auxological study. Logistic regression analysis was applied to reveal the relationship between the groups of psychosomatic health complaints and the hypothesized predictive factors.
The frequency of the most psycho-somatic complaints reached maximum values in the age-group of 21–25 years and another increase was identified in women aged 56–60. Irritability, waking up tired and awakenings during the night were the most frequently reported symptoms. The frequency of symptom of awakenings during the night increased up to the age group of 61–65 years. The results of the regression analysis revealed that the frequency of the psychic complaints and the level of physical activity affected the frequency of somatic complaints. Age, sleep disorders and somatic complaints were determinants of the psychic complaints. Postmenopausal status and the frequency of the psychic complaints influenced the frequency of sleep disorders.
Numerous factors of lifestyle and body structure were tested in the analysis. Special life events (school, work, birth of children, menopause) are suspected in the background of the highlighted periods. More factors (socioeconomic status, nutrition, health condition, disabilities) should be considered in future studies.
A Kelet-Dunántúl avar kori népességváltozásainak történeti embertani vizsgálata
Authors: SZENICZEY Tamás 
Published: December 2019

During the Early Avar period, the Eastern-Transdanubian part of the Carpathian Basin was characterized by cultural heterogeneity. Beside the late antique and Germanic cultural elements the byzantine goods as well as the steppe traditions were included in the archaeological material of this period. The multicultural milieu completely disappeared by the beginning of the Late Avar Period that was defined by a much more standardized culture. In the light of the cultural changes, could we assume that the bearers of the antique and Germanic culture of the Early Avar period are the descendants of the former Romance and Lombard groups? If so, what happened to this populations during the Avar Period, how did they interact with the steppe-originated Avars? Was the Late Avar acculturation caused by new immigrants or is it solely a cultural integration?
Based on the results of my dissertation, the continuity of the late antique and Germanic groups to the Early Avar period has been proved. The cultural influences and relations of these local populations contributed to the emergence of the Early Avar material culture of Eastern-Transdanubia. The Early Avar period males of other regions had little biological impact on the Eastern-Transdanubian population, however females migrated here to a greater extent. The sex-specific migration rate resulted that the anthropological traits of the local males persisted even through the Late Avar period, while the continuity of the females localised to Baranya-county.
During the Late Avar period new populations had arrived to Eastern-Transdanubia and occupied mostly the present territories of Tolna- and Fejér-counties. As far as Baranya-county is concerned, the Late Avar period population was formed on the basis of Romance, Germanic and Early Avar period population. The new inhabitants of Eastern-Transdanubia had biological relations with populations living in the Danube-Tisza Interfluve and along the Tisza. Since these regions cover a relatively large geographic area, further systematic comparative studies are necessary to decipher the origin of these populations. Considering that there were similarities between the locally formed Late Avar period populations of Eastern-Transdanubia and the new immigrants, their biological integration could happen rapidly. From a demographic point of view, it is not possible to establish a causal relationship between the new population and the onset of the Late Avar period. Therefore, the cultural transition could have rather been the result of a cultural integration process.
LABORATORY WORK ON TOTAL SUCTION CALIBRATION CURVE FOR WHATMAN #42 FILTER PAPER
Authors: Purwana Yusep Muslih 
Published: December 2019

<p>Soil suction is one of main parameter in unsaturated soil mechanics as its measurement is as very important as pore water pressure measurement for effective stress concept in saturated soil mechanics.Basically, the measurement of soil suction can be classified into 2 categories; direct and indirect method. In the first method, negative pore water pressure is measured directly to obtain matric suction, whereas in indirect method, suction is obtained indirectly by using salt solution and censor. Calibration is then required to establish the relationship between concentration of salt solution and censor. Filter paper method is considered as the simplest method and relatively low cost compare to other method. The studies conducted by many investigators indicate that calibration curve from one type to another type of filter paper is quite different. This paper presents the basic concepts of laboratory work on establishing total suction calibration curve for Wahtmann #42 filter paper. The work has been conducted using NaCl and KCl solutions with different molality to generate different suction. The result indicates that the higher molality of solution, the higher suction is generated. The calibration curve from KCl exhibits a bit higher compare to the one from NaCl. The difference of both curves most probably is due to the difference of equilibration period and suction source.</p><p><strong>Keywords</strong>: Calibration curve, filter paper, suction, unsaturated soil</p>
Tuning Ionic Liquids for Simultaneous Dilution and Demulsification of Water-In-Bitumen Emulsions at Ambient Temperature
Authors: Abdelfatah Elsayed , Chen Yining , Berton Paula , Rogers Robin D. , Bryant Steven L. 
Published: December 2019

Summary
Thermal and flotation processes are widely used to produce bitumen from oil sand in Alberta. However, bitumen contains many surface-active components that tend to form water-in-oil (w/o) emulsion stabilized by fines and/or asphaltenes. Although several demulsifiers have been proposed in the literature to treat such emulsions, these chemicals are sometimes not effective. We propose ionic liquids (ILs) whose composition has been designed to enable effective treatment of these emulsions.
Different ILs were synthesized and tested for their efficiency in treating bitumen emulsion obtained from a field in Alberta. ILs tested are mixtures of organic bases (primary and tertiary amines) with oleic acid. Mixtures of ILs and bitumen emulsion were prepared at several mass ratios. The two components were mixed under ambient conditions. After mixing, segregation of different components in the mixture was accelerated by centrifugation for rapid assessment of the degree of emulsion breaking. Optical microscopy, rheology, thermal gravimetric analysis, and viscosity measurements were used to assess the effect of ILs on bitumen emulsions.
The first set of ILs with primary amine cations of different alkyl chain lengths (N-butylammonium oleate, N-octylammonium oleate) were able to separate the water from the emulsion. However, these ILs tended to form gels when mixed with water. The IL prepared from a tertiary amine with short alkyl chain length, triethylammonium oleate, also formed a gel with water. The number and length of alkyl chains proved critical for avoiding gel formation. ILs with tertiary amine cations of longer alkyl chain lengths (tri-N-butylammonium oleate and tri-N-octylammonium oleate) were immiscible with the separated water and did not gel. These ILs were very efficient in diluting and demulsifying bitumen emulsion. The emulsion droplet sizes increased upon addition of the IL. The IL mixes into the bitumen phase released from the emulsion, yielding a viscosity at an ambient temperature close to the pipeline specifications.
This work demonstrates that ILs can be tailored to break bitumen emulsions effectively without heat input. The process developed in this paper can replace current practice for the demulsification and dilution of bitumen emulsions, which requires the emulsion to be heated significantly. Hence the IL process reduces the heat requirements and hence greenhouse gas emissions.
Flow-Path Tracking Strategy in a Data-Driven Interwell Numerical Simulation Model for Waterflooding History Matching and Performance Prediction with Infill Wells
Authors: Zhao Hui , Xu Lingfei , Guo Zhenyu , Zhang Qi , Liu Wei , Kang Xiaodong 
Published: December 2019

SummaryRecently, we have developed two computationally efficient data-driven models—interwell numerical simulation model (INSIM) and INSIM with front tracking (INSIM-FT)—for history matching, prediction, characterization, and optimization of waterflooding reservoirs. Then, stemming from the INSIM family, we derived a new data-driven model referred to as INSIM with flow-path tracking (FPT), for more-accurate interwell connectivity calculations, dynamic flow-path tracking, and waterflooding predictions. The model is a connection-based simulation model that is developed on the basis of a two-phase-flow material-balance equation. With the new model, we can characterize a reservoir by history matching the historical well flow-rate data without the detailed petrophysical properties of the reservoir. In INSIM-FPT, we provide an automatic and systematic workflow that incorporates Delaunay triangulation and imaginary wells to construct the model connection map. We apply a modified depth-first searching method to track all influential flow paths between an injector/producer pair for more-accurate calculations of dynamic allocation factors and control pore volumes (PVs). In addition, we provide a method to visualize a saturation field for a history-matched INSIM-FPT model. On the basis of the saturation map, we design a workflow to evaluate possible drilling locations and future performance of infill wells.For application, we create a synthetic reservoir with two different scenarios to demonstrate the reliability of INSIM-FPT. The results show that the dynamic allocation factors and control PVs between injector/producer pairs in the history-matched INSIM-FPT models are consistent with those obtained from the true streamline simulation model. Furthermore, the oil-saturation field generated with INSIM-FPT reasonably matches that obtained with the true model. It shows that the future predictions of infill wells on the basis of history-matched INSIM-FPT models are reasonably accurate but can be improved if more observed data are collected from near the planned infill wells. We also test a large-scale field problem with 65 wells, which shows INSIM-FPT can reasonably match and predict the field data.
Identification of QTL TGW12 responsible for grain weight in rice based on recombinant inbred line population crossed by wild rice (Oryza minuta) introgression line K1561 and indica rice G1025
Authors: Li Xiaoqiong , Wei Yu , Li Jun , Yang Fangwen , Chen Ying , Chen Yinghua , Guo Sibin , Sha Aihua 
Published: December 2019

Abstract

Background: Limited genetic resource in the cultivated rice may hinder further yield improvement. Some valuable genes that contribute to rice yield may be lost or lacked in the cultivated rice. Identification of the quantitative trait locus (QTL) for yield-related traits such as thousand-grain weight (TGW) from wild rice speices is desired for rice yield improvement. Results: In this study, sixteen TGW QTL were identified from a recombinant inbred line (RIL) population derived from the cross between the introgression line K1561 of Oryza minuta and the rice cultivar G1025. TGW12 , One of most effective QTL was mapped to the region of 241.47 kb between the marker 2768345 and marker 2853491 of the specific locus amplified fragment (SLAF). The origin of TGW12 was tested using three markers nearby or within the TGW12 region, but not clarified yet. Our data indicated thirty-two open reading fragments (ORFs) were present in the region. RT-PCR analysis and sequence alignment showed that the coding domain sequences of ORF12 , one MADS-box gene, in G1025 and K1561 were different due to alternative slicing, which caused premature transcription termination. The MADS-box gene was considered as a candidate of TGW12 . Conclusion: The effective QTL, TGW12 , was mapped to a segment of 241.47 kb using RILs population and a MADS-box gene was identified among several candidate genes in the segment. The region of TGW12 should be further narrowed and creation of transgenic lines will reveal the gene function. TGW12 could be applied for improvement of TGW in breeding program.
Interaction of camel Lactoferrin derived peptides with DNA: a molecular dynamics study
Authors: Pirkhezranian Zana , Tahmurespur Mojtaba , Daura Xavier , Monhemi Hassan , Sekhavati Mohammadhadi 
Published: December 2019

Abstract
Background: Lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. Here, we performed a molecular dynamics simulation study to understand the molecular interactions between camel Lactoferrin derived peptides, including CLFampin, CLFcin, and CLFchimera, and DNA as an important intracellular target. Results: Our results indicate that all three peptides bind to DNA, albeit with different propensities, with CLFchimera showing the highest binding affinity. The secondary structures of the peptides, modeled on Lactoferrin, did not undergo significant changes during simulation, supporting their functional relevance. Main residues involved in the peptide-DNA interaction were identified based on binding free energy estimates calculated over 200 ns, which, as expected, confirmed strong electrostatic interactions between DNA phosphate groups and positively charged peptide side chains. Interaction between the different concentrations of CLFchimera and DNA revealed that after binding of four copies of CLFchimera to DNA, hydrogen bonds between the two strands of DNA start to break from one of the termini. Conclusions: Importantly, our results revealed that there is no DNA-sequence preference for peptide binding, in line with a broad antimicrobial activity. Moreover, the results showed that the strength of the interaction between DNA and CLFchimera is concentration dependent. The insight provided by these results can be used for the rational redesign of natural antimicrobial peptides targeting the bacterial DNA. Keywords: Keywords: Camel, Antimicrobial peptide, DNA, Lactoferrin, Molecular dynamics simulation
Effect of Dexmedetomidine on Duration of Mechanical Ventilation in Septic Patients: A Systematic Review and Meta-Analysis
Authors: Author) peifen chen(Former Corresponding , Jiang Jihong , Zhang Yunhe , Li Guobao , Qiu Zhihui , Levy Mitchell M. , Hu Baoji 
Published: December 2019

Abstract
Background: Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on the duration of mechanical ventilation remains unclear. The present study was conducted to review the extant literature in DEX and determine its influence on ventilation time in adult septic patients.
Methods: Databases of PubMed, Cochrane, and EMBASE were applied till 20th January 2019 without language restriction. The searching strategy as following: sepsis OR septic AND mechanical ventilation AND dexmedetomidine. Two authors screened titles, abstracts, and even articles to meet the including criterion independently. In addition, references of related articles or reviews were also referred. Data was recorded in a table and analyzed using the software of Review Manager 5.0.
Results: Four studies with a total of 349 patients were included. Three trials with 267 patients revealed the effect of DEX on duration of mechanical ventilation, two trials with 264 patients on ventilator-free days and four trials with 334 patients on 28-day mortality. The analyzed results indicated that DEX was not associated with significantly different durations of mechanical ventilation (MD 0.65, 95% CI, -0.13 to 1.42, P = 0.10). However, there were significant differences in ventilator-free days (MD 3.57, 95% CI, 0.26 to 6.89, P = 0.03) and 28-day mortality (RR 0.61, 95% CI, 0.49 to 0.94, P = 0.02) in the septic patients.
Conclusion: Administration of DEX for sedation in septic patients was not associated with the duration of mechanical ventilation, but it increased the ventilator-free days and reduced 28-day mortality.
A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors
Authors: Zhang Shu'e , Wang Jinghui , Xie Fengzhe , Yin Dong , Shi Yu , Zhang Min , Yin Hongyan , Li Fujun , Yang Libin , Cao Depin , Sun Tao 
Published: December 2019

Abstract
Background: The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological attachment in the relationship between job burnout and career calling. Methods:This cross-sectional survey was conducted by administering an online questionnaire in May 2016. The survey was performed across Thirty provinces. In total,A total of 3,016 Chinese doctors were selected as participants, of which 2,617 completed valid questionnaires (effective response rate: 86.77%). Results: The overall prevalence of burnout symptoms among Chinese doctors was 85.79%. Little variance was reported for burnout symptoms according to age (Waldc2 = 6.843, P < 0.05, OR <1 ), professional title (Waldc2 = 13.110, P < 0.05, OR > 1), and daily working hours (Waldc 2= 7.226, P < 0.05, OR > 1). However, the burnout of Chinese doctors was found to be associated with psychological attachment (B = -0.6433, P < 0.0001) and career calling (B = 0.3653, P < 0.0001); furthermore, psychological attachment (B = 0.2350, P < 0.001) mediated the relationship between job burnout and career calling. Conclusion: Burnout symptoms among Chinese doctors were prevalent and associated with age, professional title, and long working hours. Chinese doctors aged 20-30 experienced a much higher level of burnout symptoms. The longer hours doctors worked, the more likely they were at risk of burnout symptoms, especially among attending physicians. Doctors who endured high-level burnout tended to exhibit decreasing psychological attachment, which threatened their sense of career calling. Finally, this paper proposed related explanations for the function mechanisms based on both theoretical and practical perspectives.