bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological status of health care workers during the outbreak of Coronavirus disease in China: a cross-sectional study
Authors: Song Xiangrui , Ni Chunyan , Cai Wenpeng , Hou Tianya , Lian Bin , Chen Aibin , Yin Qianlan , Deng Guanghui , Li Huifen 
Published: March 2020

Abstract
Background: Following the outbreak of Coronavirus disease (COVID-19) in Wuhan, China, thousands of health care workers (HCWs) joined in the battle to prevent epidemic. The purposes of this study were to assess the psychological status of health care workers fighting against COVID-19 and compared their status with non-health care workers.Methods: 1521 participants were invited to complete a cross-sectional survey which consisted of a demographic questionnaire, the symptom checklist-90 (SCL-90), the Connor-Davidson Resilience scale (CD-RISC) and Chinese-Version Social support revalued scale (SSRS). SCL-90 was used as a measure of psychological status, CD-RISC was used as a measure of resilience and SSRS was used as a measure of social support. All analyses were completed by SPSS21.0 and two-tailed with significance defined as p <0.05.Results: HCWs showed higher level of obsessive-compulsive symptoms ( p = 0.002), depression ( p =0.011), anxiety ( p = 0.037) and had lower level of subjective support ( p <0.001) as well as strength ( p =0.012). Compared with those who working in other hospital departments, HＣＷｓ working in internal medicine department had high level of obsessive-compulsive, anxiety and interpersonal sensitivity, they also had low level of social support and resilience.Conclusions: HCWs were vulnerable to mental disorders, and health organizations and government should initiate psychological assistant program to keep them immune to mental disorders. HCWs who working in internal medicine department (IMD) were supposed to rebuild their resilience, social support systems, confidence and job satisfaction under the guidance of psychologists.
A comparison between body mass index and waist circumference for identifying continuous metabolic syndrome risk score components in school-aged children using a structural equation modeling approach: the CASPIAN-V study
Authors: Ejtahed Hanieh-Sadat , Mahmoodi Zohre , qorbani mostafa , Angoorani Pooneh , Motlagh Mohammad Esmaeil , Hasani-Ranjbar Shirin , Endocrinologist Hasan Ziaodini , Taheri Majzoubeh , Heshmat Ramin , Kelishadi Roya 
Published: March 2020

Abstract
Background The purpose of this study was to investigate the association of anthropometric measures with continuous metabolic syndrome (cMetS) risk score components in a large population-based sample of children and adolescents using a path analysis. Methods This multi-centric study was performed on 3843 students aged 7-18 years who were selected by multistage, stratified cluster sampling method from 30 provinces of Iran. Demographic, anthropometric and biochemical factors were obtained and standardized residuals ( z -scores) were calculated for MetS components. A structural equation modeling approach was applied to evaluate the relationships among the study variables and to implement the subsequent structural modeling. Results The mean age of participants (52.3% boys) was 12.4±3.05 years. Standardized scores of body mass index (ZBMI) and waist circumference (ZWC) had a direct effect on standardized scores of mean arterial pressure (ZMAP) (0.23 and 0.24 in boys and 0.22 and 0.23 in girls; respectively) and triglyceride (ZTG) (0.07 and 0.04 in boys and 0.02 and 0.06 in girls; respectively), but the effect of ZWC was stronger than ZBMI on these variables. Age, socioeconomic status and sedentary behaviors showed a positive direct effect on ZWC (0.01, 0.05 and 0.07 in boys and 0.05, 0.08 and 0.002 in girls; respectively). These variables induced indirect effects on cMets risk score components through ZWC. Conclusions The magnitude of association between WC and continuous metabolic syndrome risk score components was higher compared with BMI in school-aged children, emphasizing on paying more attention to central obesity in childhood.
ABCC5 Gene Variant c.1146A&gt;G Reduces MRP5 Expression and Can be a Potential Marker to Manage Cilostazol Induced Headache
Authors: Lee Dong-Hwan , Bang Woo-Dae , Hasanuzzaman Md. , Kim So Myoung , Kim Dong-Jin , Park Joonhee , Park Kyungsoo , Lee Min Goo , Lee Seokjoon , Lee Ji Hyun , Kim So Won 
Published: March 2020

Abstract
Background: Patients taking cilostazol, a representative phosphodiesterase type III inhibitor used for vasodilation, occasionally complain of headaches. Cerebral arteriolar relaxation, due to an increase in intracellular cAMP or cGMP, is believed to be associated with a severe form of cilostazol-induced headaches. Multidrug resistance protein 5 (MRP5) is an important regulator of cAMP and cGMP could be a regulatory protein of this cilostazol induced headache.Methods: The response to cilostazol on the basis of MRP5 genetic variations was studied in phase-I clinical trial including 101 healthy Korean individuals. Quantitative real time PCR, Western blot, confocal analysis and drug transporter assay was performed to detect and evaluate the activity of MRP5. Statistical analysis was performed by using SPSS 18.0 and GraphPad Prism 4.0 software. Results: Population genetic and pharmacokinetic analyses indicated that a group of MRP5 genetic variations in linkage disequilibrium with c.1146A>G (rs7636910) is associated with the no or mild forms of cilostazol-induced headaches, but did not affect the systemic distribution of cilostazol or its metabolites. Quantitative real-time PCR and pyrosequencing assays of blood cells revealed that individuals with the c.1146G allele, a protective allele against cilostazol-induced headaches, had a 0.68-fold lower mRNA expression of MRP5 than that of individuals with c.1146A allele. In addition, in a gene transfection experiment using MDCKII cells, the G variant was found to be reduced the mRNA and protein expression of MRP5.Conclusion: These results suggest that MRP5 has an important role in the regulation of cilostazol-induced chronic headache and the c.1146A>G variation could be a potential marker to manage/treat cilostazol-induced headaches.Trial registration: The trial is registered at www.clinicaltrials.gov on (October 20, 2011) and the number is NCT01455558.
Dexmedetomidine versus ketamine in attenuating neuropathic pain through modulating STING/TBK pathway to modulate spinal ER-phagy in neuropathic pain model
Authors: Liu Yongda , Ding Mengmeng , Wang Zhibin , Li Xingyue , Guo Jiao , Han Guang , Zhao Ping 
Published: March 2020

Abstract
Background: Our previous studies suggested that stimulator of interferon genes (STING) level was altered in medial prefrontal cortex (mPFC) of spinal nerve ligation (SNL) rats.Methods: In this study, we investigated that whether dexmedetomidine and ketamine provide antianxiety and anti-nociceptive effects via modulating spinal STING/TBK pathway to alter ER-phagy in SNL rats. We evaluated the analgesia and antianxiety effects of ketamine and dexmedetomidine in SNL rats. 2’3’-cGAMP (STING pathway agonist) was administrated to investigate whether enhanced spinal STING pathway could reverse dexmedetomidine or ketamine treatment effects in SNL rats respectively. Analgesia effects were measured with mechanical withdrawal threshold (MWT) and antianxiety effect was measured with open field test (OFT). Proteins expression levels were evaluated by Western blotting. Distribution and cellular localization of STING pathway and ER stress were evaluated by confocal immunofluorescence.Results: SNL induced mechanical hypersensitivity and anxiety; STING pathway was involved in the modulation of ER stress and ER-phagy in SNL rats; Dexmedetomidine and ketamine provided analgesia and antianxiety effects in SNL rats; Dexmedetomidine and ketamine alleviated ER stress via inhibiting STING pathway to enhance ER-phagy in SNL rats.Conclusions: In all, both ketamine and dexmedetomidine provided antianxiety and anti-nociceptive effects through alleviating ER stress via inhibiting STING/TBK pathway to modulate spinal ER-phagy in SNL rats.
“Lazarus” school rising: Finding renewed hope with a “little help from our friends”
Authors: Bills Andrew , Hamilton Amy , Wadham Ben 
Published: March 2020

Abstract
This article examines the nature of sudden and sweeping organisational change when a public secondary school facing closure reframed the ideological components of schooling, finding renewed hope and direction for the future. It also attempts to explain how organisational change can take place through university-led action research, activating school community support to become a science, technology, engineering, arts and mathematics (STEAM) school, securing funding sustainability, political and bureaucratic support, and a new regional school and university partnership. Finally, it seeks to understand how teachers and leaders make sense of their new STEAM organisational identity and how they are reflecting upon this in their new work ahead.
This single bounded case study used a “sequential transformative strategy” involving an initial phase of action research reframing schooling purpose as a STEAM school. This was followed by semi-structured teacher and leader interviews hermeneutically analysed, constituting a two part project with a theoretical lens of social science theory. The theoretical perspective of Meighan’s component theory informs the analysis of the two methodologies.
The Role And Importance Of Selected Virulence Factors Determining The Pathogenicity Of Uropathogenic Escherichia Coli Strains
Authors: Chmielewska Sylwia Joanna , Leszczyńska Katarzyna 
Published: March 2020

Abstract
The most frequent etiologic agents of the urinary tract infections (UTIs) are UPEC strains (Uropathogenic Escherichia coli), which are responsible for 75–95% of UTIs. The virulence factors of UPEC bacteria, as well as their ability to form biofilm, play a significant role in the pathogenicity of UTIs. Limiting iron availability is a major host defense against the growth of microorganisms within hosts. That is why UPEC strains produce various types of siderophores as well as siderophore receptors, which facilitate the uptake and transport of iron to the bacterial cell. Moreover, in order to modulate an inflammatory response and host signaling pathways, UPEC strains produce the following toxins: α-hemolysin (HlyA), cytotoxic necrotizing factor 1 (CNF-1) and vacuolating autotransporter toxin (VAT, Vat-like/ Vat-ExEc). Moreover, Usp is a novel genotoxin of UPEC strains which provokes DNA fragmentation and cell apoptosis. Furthermore, the presence of protein Ag43 enhances adhesion of UPEC within the urinary tract, aggregation and biofilm formation. It is important to underline that all of the virulence factors mentioned above and the ability to form biofilm facilitate and enable UPEC colonization and dissemination in the urinary tract. In conclusion, UPEC harbors an arsenal of virulence factors which promote persistence within the adverse settings of the host urinary tract and finally lead to the development of UTI.
1. Introduction. 2. Iron acquisition system – siderophores, siderophore receptors. 3. Toxins. 3.1. α-hemolysin HlyA. 3.2. Cytotoxic necrotizing factor 1. 3.3. Toxin Vat. 4. Protein Usp. 5. Protein Ag43. 6. Bacterial biofilm. 7. Summary
A comparative investigation of lithium(I) biosorption properties of Aspergillus versicolor and Kluyveromyces marxianus
Authors: Günan Yücel Hande , Aksu Zümriye , Yalçınkaya Gülşah Büşra , Karatay Sevgi Ertuğrul , Dönmez Gönül 
Published: March 2020

Abstract
In the current batch study, lithium(I) ion sorption behaviors of Aspergillus versicolor fungus and newly isolated Kluyveromyces marxianus yeast were investigated comparatively. Surface and structural characterization studies of the biosorbents carried out with Fourier transform infrared spectrometer (FTIR), scanning electron microscope (SEM), surface area and zeta potential analyses showed that isolated K. marxianus yeast from salty wastes has more preferable properties (i.e. higher porosity, surface area and negativity) for cation sorption. Biosorption studies also supported this estimation; higher lithium(I) sorption capacities were obtained with K. marxianus cells at all experimental conditions studied. Rapid sorption profiles of the sorbents demonstrated that physical interaction is the main mechanism in this system. The effects of pH and initial lithium(I) concentration on the lithium(I) sorption capacities of biosorbents were examined. The maximum adsorption capacities of 347.9 and 409.2 μmol lithium(I)/g biosorbent were obtained at an initial lithium(I) concentration of 20 mg/L at pH 9.0 using A. versicolor and K. marxianus, respectively. The equilibrium data fitted both Langmuir and Freundlich models in the concentration ranges studied. This study revealed that K. marxianus yeast can be used for effective, rapid and low cost capture process of lithium(I) ions from aqueous solutions.
Graphitic carbon nitride (g-C3N4) as an efficient metal-free Fenton-like catalyst for degrading organic pollutants: the overlooked non-photocatalytic activity
Authors: Zhu G. X. , Lu T. L. , Han L. , Zhan Y. Z. 
Published: March 2020

Abstract
Graphitic carbon nitride (g-C3N4) has attracted a large amount of research, mainly being used as a photocatalyst, but its Fenton-like catalytic performance has been overlooked. In this paper, the dark Fenton-like catalytic performance of g-C3N4 was evaluated by degrading rhodamine B over a wide pH range. The results showed that the g-C3N4, which was synthesized by conventional urea pyrolysis without any modification, was an efficient metal-free heterogeneous Fenton-like catalyst. The highest activity occurred under a weakly alkaline condition of about pH 10. The experiment of catalyst recycling indicated that g-C3N4 had long-term stability. The reactive oxidizing species of HO·, generated by the g-C3N4 activating H2O2, was identified by EPR and further supported by a scavenging experiment of HO· using isopropanol as the scavenger. The HNO3 oxidation of g-C3N4 resulted in catalytic deactivation, implying the catalytic activity originated from the surface reduced groups of g-C3N4. The structure of synthesized g-C3N4 before and after the HNO3 oxidation was characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy, and a possible catalytic mechanism was proposed.
Nurturing Jawi Through Education: Mirroring Jawi Education in Aceh and Malaysia
Authors: Rizki Syukri 
Published: March 2020

As Jawi – the Arabic orthography used to write Malay language – deals with more challenges in this sophisticated era, it requires more severe acts of nurturing its existence, one of which, education. Inferred to be originated from Aceh, the massive dissemination of Jawi got through the Malay Archipelago countries, including Malaysia, where it, compared to other countries, receives better treatment for its development nowadays. This paper seeks to trace the origin of Jawi and its development in the light of education in Aceh and Malaysia. The findings reveal that Jawieducation in Malaysia has better developed with its outstanding features. Relevant journal articles, books, reports, and online pages are consulted to obtain the real picture of Jawi education in both countries. Positive innovations developed in Malaysian schools are expected to set a new benchmark for Jawi education in Aceh in particular and in other Indonesian provinces which are concerned over Jawi education like Riau, Islands of Riau, South Sumatera, North Sumatera, and Jambi.
The State of Responsibility to Protect Inception in ASEAN Regionalism
Authors: Rum Muhammad 
Published: March 2020

As a regional organization, ASEAN upholds its core principles of non-interference, consultation and consensus. Meanwhile, Responsibility to Protect (R2P) encourages the need for the international community’s intervention to a country that falls to its citizens. Hence, this creates tension between ASEAN principles and R2P. The tension is reflected when the limited capacity of a member state’s government might invite humanitarian intervention from the international community. This research aims to discuss how Southeast Asian regionalism adapts to this situation and is undergoing dynamic reformulation to reconcile ASEAN Way and humanitarian principles. In contemporary Southeast Asian Studies, the extent of R2P inception in ASEAN regional cooperation is understudied. These methods utilize a reductionist approach in I.R. studies by explaining ASEAN through the analysis of individual actors based on a constructivism school of thought. The data taken from the interviews are utilized to confirm ASEAN and member states’ positions. This study argues that the traditional constructivist tipping point measurement for an international norm needs to be revisited. The tipping points for R2P in international forums may not necessarily be well-reflected at the regional level.
El surgimiento de una esfera pública Textos de arquitectura de 1960 a 1990
Authors: Shah Riddhi 
Published: March 2020

<p>El período de 1960 a 1990 es muy importante para la aparición del discurso arquitectónico en los países del primer mundo. Fue resultado de la publicación prolífica de textos durante este período que marcaron un cambio en la práctica de la arquitectura, crearon conciencia entre los profesionales de la arquitectura y el público en general sobre el estado de la disciplina y mostraron la necesidad de alterar los métodos de conceptualización, diseño y práctica. Este artículo muestra la relación entre los medios impresos y la arquitectura, con un enfoque en los textos publicados en el período seleccionado. </p><p>El artículo se basa en la hipótesis de que hubo una publicación prolífica de textos arquitectónicos entre 1960 y 1990 y reconoce el surgimiento de la esfera pública debido al impacto de una variedad de medios impresos, como libros y revistas, en los pensamientos y las acciones humanas. Este artículo se divide en tres partes: la primera analiza la imprenta como medio de comunicación, la segunda describe la evolución de la esfera pública en la arquitectura y la tercera identifica las instituciones teóricas como parte de la esfera pública.</p>
El arte y su poder transformador. Inconsciente, emociones y creación según la perspectiva junguiana
Authors: Hernández-Mella Rocío , D’Meza-Pérez Patricia , Ramírez-Jiménez Nicole , Morel-Camacho José , Peña-Lantigua Laura , Olivier-Sterling Cynthia 
Published: March 2020

Este ensayo analiza cómo la creatividad otorga a la conciencia una fuerza renovadora y cómo su poder transformador proviene del nivel inconsciente de la psique, como se explica en la Psicología Analítica de Carl Jung y sus seguidores. En particular, se centra en mostrar cómo en el estrato más profundo del inconsciente se genera una creación visionaria que convierte al creador en una especie de medium consumido por un impulso superior a su fuerza. Un impulso, que puede expresarse en una obra artística o exteriorizarse en un brote de locura cuando no se comprende el significado profundo de la experiencia creativa en el self . El artículo también analiza la creación en sus relaciones con el desarrollo humano en el contexto de la Psicología Analítica y su conceptualización como individuación. En ese sentido, destaca cómo, a través de las emociones que una obra de arte consigue despertar en el espectador, el artista logra establecer una comunicación con su público.
Vivencias de las mujeres egresadas del Programa de Posgrado en Tecnología y Sociedad (PPGTE) de la Universidad Tecnológica Federal del Paraná (UTFPR)
Authors: De Lima Dias Maria Sara , Caldas Brognoli Paula 
Published: March 2020

Esta investigación tuvo como objetivo evaluar si aspectos de género interfieren en las trayectorias académicas. El refe-rencial teórico-epistemológico del estudio ha sido el histó-rico-cultural, para analizar distinciones existentes para las mujeres en el ejercicio de actividades investigativas. El método de investigación cualitativo fue de particular relevancia para analizar si existía una disolución de viejas desigualdades sociales dentro de la diversidad del ambiente académico. Como instrumento de investigación se utilizó la entrevista abierta, realizada a cinco mujeres egresadas del programa, tres de la maestría y dos del doctorado. El análisis de las narrativas permitió constatar que la carrera académica es una de las pocas alternativas en que la mujer puede trabajar y estudiar al mismo tiempo. En contraste, la asunción de múltiples papeles sociales y el esfuerzo emprendido para conciliar jornadas dobles de trabajo, y la falta de apoyo familiar y financiero para los estudios son vistos como obstáculos para la formación. Asimismo, las narrativas permitieron visibilizar un conjunto de “barreras” para seguir la carrera científica, que se refieren a: doble jornada de trabajo, maternidad, productividad en investi-gación, competencia, prejuicio y discriminación de género; de esta manera se reafirma la necesidad de desarrollar políticas públicas para ampliar no solo el acceso, sino la permanencia de las mujeres en la universidad.
Distorsiones fiscales y la curva de Laffer en la República Dominicana
Authors: Prazmowski Peter Albert 
Published: March 2020

Este artículo estima una curva de Laffer para la República Dominicana utilizando datos anuales desde el año 1955 hasta el 2018. Los resultados indican que la presión tributaria que maximizaría las recaudaciones fiscales es de aproximadamente un 20 %, superior al promedio histórico de 15 %. La baja presión tributaria es en parte el resultado de distorsiones fiscales que incluyen evasión, elución e informalidad. Se estima que dichas distorsiones son de aproximadamente un 60 % y su evolución histórica se corresponde con numerosos episodios, incluyendo más de veinte reformas tributarias y cinco acuerdos de estabilización con el Fondo Monetario Internacional (FMI). Las conclusiones pueden ser útiles para el diseño e implementación de políticas fiscales en general y tributarias en particular.