bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latest trends in Leishmania infantum infection in dogs in Spain, Part I: mapped seroprevalence and sand fly distributions
Authors: Gálvez Rosa , Montoya Ana , Cruz Israel , Fernández Carlos , Martín Oihane , Checa Rocío , Chicharro Carmen , Migueláñez Silvia , Marino Valentina , Miró Guadalupe 
Published: April 2020

Abstract
Background
This report describes L. infantum infection seroprevalence in dogs in Spain through data obtained from peer-reviewed literature and a cross-sectional serological survey assessing epidemiological and habitat variables as risk factors for infection. The study also provides preliminary sand fly species distribution data and indicates factors affecting their distribution and density.

Methods
Three different studies were conducted in Spain: (i) a peer-reviewed literature seroprevalence survey (1985–2019); (ii) a cross-sectional serological survey (2011–2016); and (iii) a preliminary entomological survey (2013–2014). In the cross-sectional serological survey, 1739 dogs from 74 different locations including 25 Spanish provinces were tested for L. infantum by indirect immunofluorescence antibody test (IFAT) (antibody titre ≥ 1:100). Seroprevalence of L. infantum infection was analysed by province and bioclimatic zone. Statistics were used to analyse relationships between several dog- and environment-related variables and L. infantum seroprevalence. In parallel, during 2013–2014, sand flies were collected across the Iberian Peninsula and the Balearic Islands using CDC light traps to examine relationships between habitat-related factors and sand fly species densities (number of sand flies per trap per hour).

Results
The literature review revealed that the provinces showing the highest seroprevalence were Balearic Islands (57.1%), Ourense (35.6%), Málaga (34.6%) and Cáceres (34.2%), and those showing the lowest seroprevalence were Vizcaya (0%), Cantabria (2.0%) and Álava (3.3%). In our survey, anti-Leishmania IgG antibodies were detected in 176 of the 1739 dogs rendering a seroprevalence of 10.12%. Percentage seroprevalence distributions significantly varied among bioclimatic belts. Seropositivity for L. infantum was related to size (large breed dogs versus small) and were significantly higher in younger dogs (≤ 1 years-old). In the entomological survey, 676 sand flies of five species were captured: 562 (83.13%) Phlebotomus perniciosus; 64 (9.47%) Sergentomyia minuta; 38 (5.62%) P. ariasi: 6 (0.89%) P. sergenti; and 6 (0.89%) P. papatasi. Phlebotomus perniciosus showed a greater density in the thermo-Mediterranean than in the meso-Mediterranean zone. Densities of S. minuta and P. ariasi were significantly higher in rural habitats.

Conclusions
This updated seroprevalence map of L. infantum infection in dogs in Spain defines non-endemic, hypoendemic, endemic and hyperendemic areas, and confirms P. perniciosus as the most abundant sand fly vector in Spain.
Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology
Authors: Gu Yuan-Yuan , Zhou Guan-Nan , Wang Qing , Ding Jing-Xin , Hua Ke-Qin 
Published: April 2020

Abstract
Background
Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cytology result ≥HSIL+ (high-grade squamous intraepithelial lesion or worse) were referred to colposcopy for pathological diagnosis. Methylation of S5 was quantified by pyrosequencing.

Results
The S5 classifier separates women with ≥HSIL+ from <HSIL with a high area under the curve (AUC) of 0.86 (95% CI 0.840–0.910). The cutoff of 2.85 was conducted in our study. Remarkably, all cancer cases (n = 67) were detected by S5. The sensitivity of S5 for “≥HSIL+” was 89.1% (95% CI 86.2–92.4%), and the specificity was 76.6% (95% CI 72.2–78.9%). S5 could reduce unnecessary colposcopy referrals by 74% (95% CI 71.3–78.1%) with virtually no loss of sensitivity for HSIL+, and the follow-up data support the utility of the S5 classifier.

Conclusion
The S5 classifier with high sensitivity and specificity provided increasing diagnostic information for women with HPV16/18+ and/or cytology results and could reduce the numerous unnecessary colposcopy referrals and avoid overtreatment.
Urinary [TIMP-2] × [IGFBP7] and serum procalcitonin to predict and assess the risk for short-term outcomes in septic and non-septic critically ill patients
Authors: Godi Ilaria , De Rosa Silvia , Martino Francesca , Bazzano Simona , Martin Marina , Boni Elisa , Carta Maria Rosa , Tamayo Diaz Claudia , Mari Gaia , Lorenzin Anna , de Cal Massimo , Corradi Valentina , Caprara Carlotta , Giavarina Davide , Ronco Claudio 
Published: April 2020

AbstractBackgroundBiomarkers can play a critical role by facilitating diagnosis and stratification of disease, as well as assessment or prediction of disease severity. Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 product ([TIMP-2] × [IGFBP7]) predict the development and progression of AKI and recently procalcitonin (PCT), a widely used biomarker for sepsis diagnosis and management, has been associated with AKI occurrence in ICU patients. To assess combinations of [TIMP-2] × [IGFBP7] and PCT results for prediction and risk stratification of short-term outcomes in septic and non-septic patients, a retrospective cohort analysis of critically ill patients was performed in a multidisciplinary ICU. ROC curve analysis was used in order to evaluate predictive performance of combined results of [TIMP-2] × [IGFBP7] and PCT at the time of admission for AKI development. To verify the utility of adding [TIMP-2] × [IGFBP7] and PCT results for risk assessment, we evaluated the predictive value of having a single-marker positivity compared to a double-marker positivity using the widely used cut-off of 0.3 (ng/mL)2/1000 for [TIMP-2] × [IGFBP7] and 0.5 μg/L for PCT. Risk assessment for AKI occurrence within 48 h, acute kidney disease (AKD) and mortality at 7 days was performed by logistic/Cox regression analysis.Results433 patients were analysed, of whom 168 had AKI within 48 h (93 septic and 65 non-septic patients). Combination of [TIMP-2] × [IGFBP7] and PCT showed a good predictive ability for AKI occurrence (AUC 0.81, 95% CI 0.77–0.86,p < 0.001, Sens 78%, Spec 73%). Combinations of biomarkers increased the odd ratios (OR) considerably. A single-marker positivity showed a fourfold risk increase, while the double-marker positivity a 26-fold risk increase for AKI occurrence. Moreover, the double-marker positivity showed an elevated risk for AKD at 7 days in non-septic patients (OR 15.9, 95% CI 3,21–73,57,p < 0.001) and for mortality within 7 days in septic patients (HR 4.1, 95% CI 1.4–11.8,p = 0.001).ConclusionsAlthough combining the results of [TIMP-2] × [IGFBP7] and PCT may be a useful tool to identify and stratify ICU patients at high risk for septic AKI and short-term adverse outcomes, data should be confirmed in a large prospective study.
A reliable technique to study nonlinear time-fractional coupled Korteweg–de Vries equations
Authors: Akinyemi Lanre , Iyiola Olaniyi S. 
Published: April 2020

AbstractThis paper employs an efficient technique, namely q-homotopy analysis transform method, to study a nonlinear coupled system of equations with Caputo fractional-time derivative. The nonlinear fractional coupled systems studied in this present investigation are the generalized Hirota–Satsuma coupled with KdV, the coupled KdV, and the modified coupled KdV equations which are used as a model in nonlinear physical phenomena arising in biology, chemistry, physics, and engineering. The series solution obtained using this method is proved to be reliable and accurate with minimal computations. Several numerical comparisons are made with well-known analytical methods and the exact solutions when $\alpha =1$α=1. It is evident from the results obtained that the proposed method outperformed other methods in handling the coupled systems considered in this paper. The effect of the fractional order on the problem considered is investigated, and the error estimate when compared with exact solution is presented.
Persuasive antimicrobial stewardship intervention in the context of a KPC outbreak: a controlled interrupted time series analysis
Authors: Rocha-Pereira Nuno , Figueiredo Dias Paulo , Correia Sofia , Shahriari Shirin , Neves João , Teixeira José , Paiva José Artur , Lima Alves Carlos , Azevedo Ana 
Published: April 2020

Abstract
Introduction
Antimicrobial resistance is a major public health threat. Antimicrobial stewardship (AMS) is one of the key strategies to overcome resistance, but robust evidence on the effect of specific interventions is lacking. We report an interrupted time series (ITS) analysis of a persuasive AMS intervention implemented during a KPC producing Klebsiella pneumoniae outbreak.

Methods
A controlled ITS for carbapenem consumption, total antibiotic consumption and antibiotic-free days, between January 2012 and May 2018 was performed, using segmented regression analysis. The AMS intervention was implemented in the Vascular Surgery ward starting on April 2016 in the context of a KPC outbreak. The General Surgery ward was taken as a control group. Data were aggregated by month for both wards, including 51 pre-intervention and 26 intervention points.

Results
The AMS intervention produced a level change in carbapenem consumption of − 11.14 DDDs/100 patient-days accompanied by a decreasing trend of total antibiotic consumption and stable rate of antibiotic-free days in Vascular Surgery ward. These differences were not apparent in the control group. No differences in mortality or readmission rates between pre-intervention and intervention periods were noticed in any of the groups.

Conclusion
Persuasive AMS interventions on top of previously implemented restrictive interventions can reduce carbapenem consumption without increasing total antibiotic consumption. Starting persuasive AMS interventions in an outbreak setting does not compromise the sustainability of the intervention.
The boon and bane of boldness: movement syndrome as saviour and sink for population genetic diversity
Authors: Premier Joseph , Fickel Jörns , Heurich Marco , Kramer-Schadt Stephanie 
Published: April 2020

Abstract
Background
Many felid species are of high conservation concern, and with increasing human disturbance the situation is worsening. Small isolated populations are at risk of genetic impoverishment decreasing within-species biodiversity. Movement is known to be a key behavioural trait that shapes both demographic and genetic dynamics and affects population survival. However, we have limited knowledge on how different manifestations of movement behaviour translate to population processes. In this study, we aimed to 1) understand the potential effects of movement behaviour on the genetic diversity of small felid populations in heterogeneous landscapes, while 2) presenting a simulation tool that can help inform conservation practitioners following, or considering, population management actions targeting the risk of genetic impoverishment.

Methods
We developed a spatially explicit individual-based population model including neutral genetic markers for felids and applied this to the example of Eurasian lynx. Using a neutral landscape approach, we simulated reintroductions into a three-patch system, comprising two breeding patches separated by a larger patch of differing landscape heterogeneity, and tested for the effects of various behavioural movement syndromes and founder population sizes. We explored a range of movement syndromes by simulating populations with various movement model parametrisations that range from ‘shy’ to ‘bold’ movement behaviour.

Results
We find that movement syndromes can lead to a higher loss of genetic diversity and an increase in between population genetic structure for both “bold” and “shy” movement behaviours, depending on landscape conditions, with larger decreases in genetic diversity and larger increases in genetic differentiation associated with bold movement syndromes, where the first colonisers quickly reproduce and subsequently dominate the gene pool. In addition, we underline the fact that a larger founder population can offset the genetic losses associated with subpopulation isolation and gene pool dominance.

Conclusions
We identified a movement syndrome trade-off for population genetic variation, whereby bold-explorers could be saviours - by connecting populations and promoting panmixia, or sinks - by increasing genetic losses via a ‘founder takes all’ effect, whereas shy-stayers maintain a more gradual genetic drift due to their more cautious behaviour. Simulations should incorporate movement behaviour to provide better projections of long-term population viability and within-species biodiversity, which includes genetic diversity. Simulations incorporating demographics and genetics have great potential for informing conservation management actions, such as population reintroductions or reinforcements. Here, we present such a simulation tool for solitary felids.
Review and insight on the behavioral aspects of cybersecurity
Authors: Maalem Lahcen Rachid Ait , Caulkins Bruce , Mohapatra Ram , Kumar Manish 
Published: April 2020

AbstractStories of cyber attacks are becoming a routine in which cyber attackers show new levels of intention by sophisticated attacks on networks. Unfortunately, cybercriminals have figured out profitable business models and they take advantage of the online anonymity. A serious situation that needs to improve for networks’ defenders. Therefore, a paradigm shift is essential to the effectiveness of current techniques and practices. Since the majority of cyber incidents are human enabled, this shift requires expanding research to underexplored areas such as behavioral aspects of cybersecurity. It is more vital to focus on social and behavioral issues to improve the current situation. This paper is an effort to provide a review of relevant theories and principles, and gives insights including an interdisciplinary framework that combines behavioral cybersecurity, human factors, and modeling and simulation.
Computational simulations of near-continuum gas flow using Navier-Stokes-Fourier equations with slip and jump conditions based on the modal discontinuous Galerkin method
Authors: Chourushi T. , Rahimi A. , Singh S. , Myong R. S. 
Published: April 2020

AbstractBlunt-body configurations are the most common geometries adopted for non-lifting re-entry vehicles. Hypersonic re-entry vehicles experience different flow regimes during flight due to drastic changes in atmospheric density. The conventional Navier-Stokes-Fourier equations with no-slip and no-jump boundary conditions may not provide accurate information regarding the aerothermodynamic properties of blunt-bodies in flow regimes away from the continuum. In addition, direct simulation Monte Carlo method requires significant computational resources to analyze the near-continuum flow regime. To overcome these shortcomings, the Navier-Stokes-Fourier equations with slip and jump conditions were numerically solved. A mixed-type modal discontinuous Galerkin method was employed to achieve the appropriate numerical accuracy. The computational simulations were conducted for different blunt-body configurations with varying freestream Mach and Knudsen numbers. The results show that the drag coefficient decreases with an increased Mach number, while the heat flux coefficient increases. On the other hand, both the drag and heat flux coefficients increase with a larger Knudsen number. Moreover, for an Apollo-like blunt-body configuration, as the flow enters into non-continuum regimes, there are considerable losses in the lift-to-drag ratio and stability.
Modified selective aortic root reconstruction with valve repair for treatment of Stanford A aortic dissection
Authors: Abd Al Jawad Mohammed 
Published: April 2020

Abstract
Background
Acute aortic dissection is a serious emergency with a significant impact on mortality and morbidity. Many patients present with hemodynamic instability that may prevent them from being transported to more experienced centers. We aim to present our experience with a modified limited root approach in terms of the operative details and early results.

Results
This retrospective study included 27 patients who presented with Stanford A aortic dissection and underwent modified selective root replacement. All patients were followed up using transthoracic echocardiography at 6 months postoperatively and at yearly intervals thereafter. Computed tomography (CT) angiography was performed 12 months after the initial surgery.
A total of 92.6% of patients required concomitant aortic valve repair. There was no operative mortality related to the operation itself; however, four patients died during the follow-up period. One patient developed new severe aortic regurgitation in the 6th month of follow-up. One patient developed a pseudoaneurysm related to the suture line that was diagnosed by CT angiography in the 16th month of follow-up.

Conclusions
The early results of modified selective root reconstruction with aortic valve repair are promising. This procedure is a quick, reliable, easily reproducible, and technically undemanding valve-sparing treatment for acute aortic root dissection.
Recherchepraxis bei der Verbesserung von Interferenzfehlern aus dem Italienischen, Portugiesischen und Spanischen: Eine explorative Beobachtungsstudie mit DaF-Lernenden
Authors: Müller-Spitzer Carolin , Nied Curcio Martina , Domínguez Vázquez María José , Silva Dias Idalete Maria , Wolfer Sascha 
Published: April 2020

AbstractIn the past two decades, more and more dictionary usage studies have been published, but most of them deal with the question what users appreciate about dictionaries, which dictionaries they use and which information they need in specific situations. These studies presuppose that users indeed consult lexicographic resources. However, language teachers and lecturers of linguistics often have the impression that students use too few high-quality dictionaries in their every-day work. Against this background, we started an international cooperation project to collect empirical data evaluating that impression. Our aim was to evaluate what students (here from the Romance language area) actually do when they correct language problems. We used a new methodological setting to do this (screen recording with a thinking-aloud task). The empirical data we gained offers a broad insight into what language users really do when solving language-related tasks today.
Wörterbuchbenutzung von polnischen Germanistikstudierenden
Authors: Taborek Janusz 
Published: April 2020

AbstractIn this paper we present the results of a survey conducted among students of German Philology at Adam Mickiewicz University in Poznań in the years 2015–2017. The target group was composed of first-semester students from whom we collected data about their lexicographical competence at the start of the program. The results contain some interesting findings, e.g. students prefer online dictionaries, but the number of students using print dictionaries is comparable and we have also observed the rising number of students who use smartphone applications. The aim of the survey is to provide information for university instructors who teach German as a foreign language (DaF) and lexicography.
Ertragsstruktur und Ergebnisentwicklung von Genossenschaftsbanken
Authors: Helms Nils , Kalhöfer Christian , Hölscher Reinhold 
Published: April 2020

Zusammenfassung
Gegenstand der vorliegenden Untersuchung sind die vergangene und die zukünftige Ertragsentwicklung von Genossenschaftsbanken. Im Rahmen einer einperiodischen sowie mehrperiodischen Simulation ergab sich in vielen Fällen eine Reingewinnspanne, die in der historischen Betrachtungsperiode niemals oder nur äußerst selten unterschritten wurde. Nicht zuletzt vor dem Hintergrund der vermutlich steigenden Eigenkapitalanforderungen folgt daraus für die Genossenschaftsbanken ein deutlicher Handlungsbedarf.
L’importance d’instaurer un climat de confiance pour profiter pleinement de la démarche des cercles d’auteurs
Authors: Rainville Brigitte , Turgeon Elaine 
Published: April 2020

Dans cet article, une enseignante témoigne de l’importance qu’elle attribue au fait d’installer un climat favorable aux échanges avant de démarrer les cercles d’auteurs. Elle partage, en toute humilité, quelques moyens pour y parvenir devenus, au fil du temps, des incontournables dans sa classe. Elle expose d’abord comment elle s’y prend pour développer un climat de classe bienveillant, puis, pour donner le goût d’écrire à ses élèves. Elle explique finalement comment elle met en place, de façon progressive et à l’aide de la modélisation, ses premiers cercles d’auteurs, et expose quelques problèmes rencontrés ainsi que des pistes de solution.
The Domain-General Multiple Demand (MD) Network Does Not Support Core Aspects of Language Comprehension: A Large-Scale fMRI Investigation
Authors: Diachek Evgeniia , Blank Idan , Siegelman Matthew , Affourtit Josef , Fedorenko Evelina 
Published: April 2020

Aside from the language-selective left-lateralized frontotemporal network, language comprehension sometimes recruits a domain-general bilateral frontoparietal network implicated in executive functions: the multiple demand (MD) network. However, the nature of the MD network's contributions to language comprehension remains debated. To illuminate the role of this network in language processing in humans, we conducted a large-scale fMRI investigation using data from 30 diverse word and sentence comprehension experiments (481 unique participants [female and male], 678 scanning sessions). In line with prior findings, the MD network was active during many language tasks. Moreover, similar to the language-selective network, which is robustly lateralized to the left hemisphere, these responses were stronger in the left-hemisphere MD regions. However, in contrast with the language-selective network, the MD network responded more strongly (1) to lists of unconnected words than to sentences, and (2) in paradigms with an explicit task compared with passive comprehension paradigms. Indeed, many passive comprehension tasks failed to elicit a response above the fixation baseline in the MD network, in contrast to strong responses in the language-selective network. Together, these results argue against a role for the MD network in core aspects of sentence comprehension, such as inhibiting irrelevant meanings or parses, keeping intermediate representations active in working memory, or predicting upcoming words or structures. These results align with recent evidence of relatively poor tracking of the linguistic signal by the MD regions during naturalistic comprehension, and instead suggest that the MD network's engagement during language processing reflects effort associated with extraneous task demands.SIGNIFICANCE STATEMENTDomain-general executive processes, such as working memory and cognitive control, have long been implicated in language comprehension, including in neuroimaging studies that have reported activation in domain-general multiple demand (MD) regions for linguistic manipulations. However, much prior evidence has come from paradigms where language interpretation is accompanied by extraneous tasks. Using a large fMRI dataset (30 experiments/481 participants/678 sessions), we demonstrate that MD regions are engaged during language comprehension in the presence of task demands, but not during passive reading/listening, conditions that strongly activate the frontotemporal language network. These results present a fundamental challenge to proposals whereby linguistic computations, such as inhibiting irrelevant meanings, keeping representations active in working memory, or predicting upcoming elements, draw on domain-general executive resources.