bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are there any novel markers in acute rheumatic fever: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio
Authors: Giray Dilek , Hallioglu Olgu 
Published: May 2020

AbstractObjective:The aim of this study was to investigate the relationship between C-reactive protein and erythrocyte sedimentation rate and neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in acute rheumatic fever in children.Method:In this retrospective study, 182 patients with acute rheumatic fever and 173 controls were included. Complete blood count parameters, and neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were recorded for all the patients underwent transthoracic echocardiography.Results:Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p < 0.05). C-reactive protein and erythrocyte sedimentation rate levels were found to have a positive correlation with neutrophil-to-lymphocyte (r = 0.228, p = 0.001; r = 0.355, p = 0.001), platelet-to-lymphocyte (r = 0.227, p = 0.01; r = 0.149, p = 0.005), and monocyte-to-lymphocyte ratios (r = 0.117, p = 0.005; r = 0.107, p = 0.044). Cardiac involvement was present in 152 (83.5%) of the patients. Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were significantly higher in patients with rheumatic heart disease than patients without cardiac involvement (p < 0.05). Patients with carditis were grouped according to mitral, aortic, or both valve involvement but there was no significant difference between the groups with respect to neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios. In addition, neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios were significantly higher in patients with Sydenham’s chorea than without chorea (p < 0.05).Conclusion:Neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios may help make the diagnosis of acute rheumatic fever and its prognosis by serial measurements in follow-up but none of them tell us the severity of carditis. Also, this is the first study showing the positive correlation between Sydenham’s chorea and neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios. Further studies are needed to confirm this hypothesis, as this is the first study in the literature on this topic.
The progression of an acceptable pulmonary stenosis immediately after total correction of tetralogy of Fallot
Authors: Kim Yi-Seul , Song Jinyoung , Huh June , Kang I-Seok , Yang Ji-Hyuk , Jun Tae-Gook 
Published: May 2020

AbstractBackground:A certain degree of pulmonary stenosis after total correction of tetralogy of Fallot has been considered acceptable. But the long-term outcomes are not well understood. We observed the natural course of immediate pulmonary stenosis and investigated related factors for progression.Methods:Fifty-two patients with acceptable pulmonary stenosis immediately after operation were enrolled. Acceptable pulmonary stenosis was defined as peak pressure gradient between 15 and 45 mmHg by Doppler echocardiography. Latent class linear mixed model was used to differentiate patients with progressed pulmonary stenosis, and the factors related to progression were analysed.Results:Pulmonary stenosis progressed in 14 patients (27%). Between the progression group and no progression group, there were no significant differences in operative age, sex, and the use of the transannular patch technique. However, immediate gradient was higher in the progression group (32.1 mmHg versus 25.7 mmHg, p = 0.009), and the cut-off value was 26.8 mmHg (sensitivity = 65.3%, specificity = 65.8%). Main stenosis at the sub-valve was observed more frequently in the progression group (85.7% versus 52.6%, p = 0.027). Despite no difference in the preoperative pulmonary valve z value, the last follow-up pulmonary valve z value was significantly lower in the progression group (−1.15 versus 0.35, p = 0.002).Conclusions:Pulmonary stenosis immediately after tetralogy of Fallot total correction might progress in patients with immediate pulmonary stenosis higher than ≥26.8 mmHg and the main site was sub-valve area.
Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis
Authors: Reist Christopher , Streja Elani , Tang Cynthia Crystal , Shapiro Bryan , Mintz Jim , Hollifield Michael 
Published: May 2020

AbstractBackgroundPrazosin has been an accepted treatment for patients with post-traumatic stress disorder (PTSD) who experience sleep disturbances, including nightmares. Results of a recent large randomized control trial did not find benefit of prazosin vs placebo in improving such outcomes. A meta-analysis that includes this most recent trial was conducted to examine the pooled effect of prazosin vs placebo on sleep disturbances and overall PTSD symptoms in patients with PTSD.MethodsA systematic review of the published literature on trials comparing prazosin vs placebo for improvement of overall PTSD scores, nightmares, and sleep quality was conducted. Hedges’ g standardized mean differences (SMD) between prazosin and placebo were calculated for each outcome across studies.ResultsSix randomized placebo-controlled studies representing 429 patients were included in the analysis, including two studies with a crossover design. Results showed prazosin significantly improved overall PTSD scores (SMD = −0.31; 95% confidence intervals [CI]: −0.62, −0.01), nightmares (SMD = −0.75; 95% CI: −1.24, −0.27), and sleep quality (SMD = −0.57; 95% CI: −1.02, −0.13). In the largest trial, prazosin showed a reduction in clinical outcome measures similar to past studies, but a relatively large placebo effect size, particularly for nightmares, contributed to no treatment differences.ConclusionsDespite the results of a recent, large randomized study, pooled effect estimates show that prazosin has a statistically significant benefit on PTSD symptoms and sleep disturbances. Limitations that should be considered include heterogeneity of study design and study populations as well as the small number of studies conducted and included in this meta-analysis.
Challenges and opportunities for enhanced cognitive behaviour therapy (CBT-E) in light of COVID-19
Authors: Murphy Rebecca , Calugi Simona , Cooper Zafra , Dalle Grave Riccardo 
Published: May 2020

Abstract
In the past few weeks, coronavirus disease 2019 (COVID-19) has dramatically expanded across the world. To limit the spread of COVID-19 and its negative consequences, many countries have applied strict social distancing rules. In this dramatic situation, people with eating disorders are at risk of their disorder becoming more severe or relapsing. The risk comes from multiple sources including fears of infection and the effects of social isolation, as well as the limited availability of adequate psychological and psychiatric treatments. A potential practical solution to address some of these problems is to deliver enhanced cognitive behaviour therapy (CBT-E), an evidence-based treatment for all eating disorders, remotely. In this guidance we address three main topics. First, we suggest that CBT-E is suitable for remote delivery and we consider the challenges and advantages of delivering it in this way. Second, we discuss new problems that patients with eating disorders may face in this period. We also highlight potential opportunities for adapting some aspects of CBT-E to address them. Finally, we provide guidelines about how to adapt the various stages, strategies and procedures of CBT-E for teletherapy use in the particular circumstances of COVID-19.

Key learning aims

(1)
To appreciate that CBT-E is suitable for remote delivery, and to consider the main challenges and potential advantages of this way of working.

(2)
To identify and discuss the additional eating disorder-related problems that may arise as a result of COVID-19, as well as potential opportunities for adapting some aspects of CBT-E to address them.

(3)
To learn how to adapt CBT-E for remote delivery to address the consequences of COVID-19. Specifically, to consider adaptations to the assessment and preparation phase, the four stages of treatment and its use with underweight patients and adolescents.
Ventilation in the Arctic Ocean and the Role of Pacific Inflow Deduced From Transient Tracer Measurements
Authors: Wang Weimin , Zheng Xiaoling , Huang Peng , Chen Mian , Teng Fang , Cai Minggang , Deng Hengxiang , Luo Bojun , Zheng Xuehong , Ke Hongwei 
Published: May 2020

AbstractDuring the seventh Chinese National Arctic Research Expedition, measurements of CFC‐12 and SF6 were used to estimate ventilation time scales and anthropogenic CO2 (Cant) concentrations in the Arctic Ocean and Bering Sea based on the transit time distribution (TTD) method. The profile distribution showed that there was a high CFC tongue entering through the Canada Basin in the intermediate layer (27.6 kg m−3 < σθ < 28 kg m−3), at latitudes between 75 and 85°N, related to the inflow of Atlantic water. The result shows that both intermediate and deep/bottom waters are better ventilated in the Arctic Ocean than in the Bering Sea. The mean age gradient of the Bering Sea Surface Water and Pacific water core of the southwest Canada Basin (24.7 < σθ < 26.2) could be a consequence of intensive mixing and entrainment of the inflow water from the Bering Sea. An expected difference in age between these areas was interpreted to reflect the transit time for the given water layers. Thus, a mean transit time from the Bering Sea (175.2–179.9°E, 59.7–61.6°N) to the western Arctic Ocean (151.6–158°W, 73.1–74.8°N) of 14.6 ± 4.6 years was estimated. The mean Cant column inventory in the upper 2,000 m was higher (~45 mol m−2) in the Arctic Ocean than in the Bering Sea (~25 mol m−2).
Zonal Wave Number Diagnosis of Rossby Wave‐Like Oscillations Using Paired Ground‐Based Radars
Authors: He Maosheng , Yamazaki Yosuke , Hoffmann Peter , Hall Chris M. , Tsutsumi Masaki , Li Guozhu , Chau Jorge Luis 
Published: May 2020

AbstractFree traveling Rossby wave normal modes (RNMs) are often investigated through large‐scale space‐time spectral analyses, which therefore is subject to observational availability, especially in the mesosphere. Ground‐based mesospheric observations were broadly used to identify RNMs mostly according to the periods of RNMs without resolving their horizontal scales. The current study diagnoses zonal wave numbers of RNM‐like oscillations occurring in mesospheric winds observed by two meteor radars at about 79°N. We explore four winters comprising the major stratospheric sudden warming events (SSWs) 2009, 2010, and 2013. Diagnosed are predominant oscillations at the periods of 10 and 16 days lasting mostly for three to five whole cycles. All dominant oscillations are associated with westward zonal wave number m=1, excepting one 16‐day oscillation associated with m=2. We discuss the m=1 oscillations as transient RNMs and the m=2 oscillation as a secondary wave of nonlinear interaction between an RNM and a stationary Rossby wave. All the oscillations occur around onsets of the three SSWs, suggesting associations between RNMs and SSWs. For comparison, we also explore the wind collected by a similar network at 54°N during 2012–2016. Explored is a manifestation of 5‐day wave, namely, an oscillation at 5–7 days with m=1), around the onset of SSW 2013, supporting the associations between RNMs and SSWs.
Hydrology of a Perennial Firn Aquifer in Southeast Greenland: An Overview Driven by Field Data
Authors: Miller Olivia , Solomon D. Kip , Miège Clément , Koenig Lora , Forster Richard , Schmerr Nicholas , Ligtenberg Stefan R. M. , Legchenko Anatoly , Voss Clifford I. , Montgomery Lynn , McConnell Joseph R. 
Published: May 2020

AbstractFirn aquifers have been discovered across regions of the Greenland ice sheet with high snow accumulation and melt rates, but the processes and rates that sustain these aquifers have not been fully quantified or supported by field data. A quantitative description of the hydrology of a firn aquifer upslope from Helheim Glacier that integrates field measurements is presented to constrain melt and recharge rates and timing, temporal variations in temperature and water levels, and liquid‐water residence time. Field measurements include weather data, firn temperatures, water levels, geochemical tracers, and airborne radar data. Field measurements show that once the firn column is temperate (0°C), meltwater from the surface infiltrates to the water table in less than 2 days and raises the water table. Average recharge is 22 cm/year (lower 95% confidence interval is 13 cm/year and upper 95% confidence interval is 33 cm/year). Meltwater within the recently formed aquifer, which flows laterally downslope and likely discharges into crevasses, has a mean residence time of ~6.5 years. Airborne radar data suggest that the aquifer in the study area continues to expand inland, presumably from Arctic warming. These comprehensive field measurements and integrated description of aquifer hydrology provide a comprehensive, quantitative framework for modeling fluid flow through firn, and understanding existing and yet undiscovered firn aquifers, and may help researchers evaluate the role of firn aquifers in climate change impacts.
Associations of interruptions to leisure-time sedentary behaviour with symptoms of depression and anxiety
Authors: Hallgren Mats , Nguyen Thi-Thuy-Dung , Owen Neville , Vancampfort Davy , Smith Lee , Dunstan David W. , Andersson Gunnar , Wallin Peter , Ekblom-Bak Elin 
Published: May 2020

AbstractInterruptions to time spent sitting can ameliorate detrimental metabolic-health consequences of high volumes of sedentary time, but their potential mental health benefits have not been examined. We used the Swedish Health Profile Assessment database, a general health assessment offered to all employees working for companies or organisations connected to occupational and health services. Cross-sectional analyses examined data from 40,550 employees (60% male, mean age = 42 years), collected in 2017–2019. Participants reported the proportion of time (almost always; 75% of the time; 50% of the time; 25% of the time; and almost never) usually spent in leisure-time sedentary behaviours; and, separately, the frequency (never; rarely; sometimes; often; and very often) of interruptions (every 30 min) to sedentary time. Logistic regression models assessed associations of sedentary time, and the frequency of interruptions to sedentary time, with depression/anxiety symptoms. Fully adjusted models included physical exercise. Compared to those in the lowest sedentary time category, those in the medium and high categories had 1.52 (95% confidence interval (CI) = 1.40–1.66) and 3.11 (95% CI = 2.82–3.42) higher odds of frequent depression/anxiety symptoms, respectively. Compared to those who never/rarely interrupted their sedentary time, those who reported interruptions sometimes, often and very often had 0.72 (95% CI = 0.65–0.80), 0.59 (95% CI = 0.53–0.65), and 0.53 (95% CI = 0.46–0.59) lower odds of depression/anxiety symptoms, respectively. In stratified analyses, more frequent interruptions to sedentary time were associated with lower odds of depression/anxiety symptoms, except among those in the lowest interruptions categories (never/25% of the time). More regularly interrupting sitting during leisure-time may reduce the odds of experiencing symptoms of depression and anxiety.
Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder
Authors: Okazaki Satoshi , Numata Shusuke , Otsuka Ikuo , Horai Tadasu , Kinoshita Makoto , Sora Ichiro , Ohmori Tetsuro , Hishimoto Akitoyo 
Published: May 2020

AbstractThere is high mortality among patients with bipolar disorder (BD). Studies have reported accelerated biological aging in patients with BD. Recently, Horvath and Hannum et al. independently developed DNA methylation (DNAm) profiles as “epigenetic clocks,” which are the most accurate biological age estimate. This led to the development of two accomplished measures of epigenetic age acceleration (EAA) using blood samples, namely, intrinsic and extrinsic EAA (IEAA and EEAA, respectively). IEAA, which is based on Horvath’s clock, is independent of blood cell counts and indicates cell-intrinsic aging. On the other hand, EEAA, which is based on Hannum’s clock, is associated with age-dependent changes in blood cell counts and indicates immune system aging. Further, Lu et al. developed the “GrimAge” clock, which can strongly predict the mortality risk, and DNAm-based telomere length (DNAmTL). We used a DNAm dataset from whole blood samples obtained from 30 patients with BD and 30 healthy controls. We investigated Horvath EAA, IEAA, Hannum EAA, EEAA, Grim EAA, DNAmTL, and DNAm-based blood cell composition. Compared with controls, there was a decrease in Horvath EAA and IEAA in patients with BD. Further, there was a significant decrease in Horvath EAA and IEAA in patients with BD taking medication combinations of mood stabilizers (including lithium carbonate, sodium valproate, and carbamazepine) than in those taking no medication/monotherapy. This study provides novel evidence indicating decelerated epigenetic aging associated with mood stabilizers in patients with BD.
Survival benefit of tamoxifen in male breast cancer: prospective cohort analysis
Authors: Eggemann Holm , Brucker Cosima , Schrauder Michael , Thill Marc , Flock Felix , Reinisch Mattea , Costa Serban-Dan , Ignatov Atanas 
Published: May 2020

Abstract
Background
Due to the lack of prospective data, current treatment of male breast cancer (MBC) is based on information obtained from retrospective analysis or by extrapolation from studies on female patients. In this prospectively enrolled cohort study, we retrospectively examined the survival effect of tamoxifen in MBC patients.

Methods
In this prospectively enrolled cohort study, 448 patients with MBC were treated between May 2009 and June 2018. The primary endpoint was disease-free survival (DFS).

Results
Between May 2009 and June 2018, 448 men with breast cancer were identified, with a median age at diagnosis of 69 years (range 27–96 years). The median follow-up was 39 months (range 3–89 months). Most tumours were larger than 20 mm; invasive ductal carcinoma was of no special histological type and with an intermediate grade of differentiation. Almost half of the men were diagnosed with positive axillary lymph nodes (43.5%). Hormone receptor (HR) positivity was observed in 98.4% of the patients. Notably, DFS among men who did not receive tamoxifen was significantly reduced as compared with those who underwent tamoxifen therapy (P = 0.002). The recurrence rate and mortality in the group of patients without and with tamoxifen treatment were 18.2% and 11.2%, respectively. The most common localisation of metastases was the bone. After adjustment for prognostic factors, we found that tamoxifen was found to reduce the recurrence rate by 68% (hazard ratio HR = 0.32; 95% confidence interval, CI: 0.14–0.74).

Conclusions
Tamoxifen treatment was associated with improved DFS for MBC patients.

Clinical trial registration
DRKS00009536.
LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter
Authors: Ni Hongyan , Chai Peiwei , Yu Jie , Xing Yue , Wang Shaoyun , Fan Jiayan , Ge Shengfang , Wang Yefei , Jia Renbing , Fan Xianqun 
Published: May 2020

AbstractRetinoblastoma (RB) is the most common malignant intraocular tumor of childhood. Recent studies have shown that long noncoding RNAs (lncRNAs), which are longer than 200 bp and without protein-coding ability, are key regulators of tumorigenesis. However, the role of lncRNAs in retinoblastoma remains to be elucidated. In this study, we found that the expression of lncRNA CASC15-New-Transcript 1 (CANT1) was significantly downregulated in RB. Notably, overexpression of CANT1 significantly inhibited RB growth both in vitro and in vivo. Furthermore, lncRNA CANT1, which was mainly located in the nucleus, occupied the promoter of phosphoinositide 3-kinase gamma (PI3Kγ) and blocked histone methyltransferase hSET1 from binding to the PI3Kγ promoter, thus abolishing hSET1-mediated histone H3K4 trimethylation of the PI3Kγ promoter and inhibiting PI3Kγ expression. Furthermore, we found that silencing PI3Kγ either by lncRNA CANT1 overexpression or by PI3Kγ siRNA, reduced the activity of PI3K/Akt signaling and suppressed RB tumorigenesis. In summary, lncRNA CANT1 acts as a suppressor of RB progression by blocking gene-specific histone methyltransferase recruitment. These findings outline a new CANT1 modulation mechanism and provide an alternative option for the RB treatment.
The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
Authors: Guo Wei , Mu Kun , Zhang Bin , Sun Chao , Zhao Ling , Dong Zhan-Yin , Cui Qing 
Published: May 2020

AbstractIntervertebral disc degeneration (IDD) is an important factor leading to low back pain, although the underlying mechanisms remain poorly understood. In this study we examined the role of circular RNA FAM169A (circ-FAM169A) in degenerative nucleus pulposus (NP) tissues, and validated its function in cultured human NP cells. Overexpression of circ-FAM169A in NP cells markedly enhanced extracellular matrix (ECM) catabolism and suppressed ECM anabolism in NP cells. Furthermore, circ-FAM169A sequestered miR-583, which could potentially upregulate BTRC, an inducer of the NF-κB signaling pathway. In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling. These findings provide a potential therapeutic option for the treatment of IDD.
IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia
Authors: Jin Rui , Xu Junjie , Gao Qianqian , Mao Xiaonan , Yin Jiao , Lu Keyu , Guo Yan , Zhang Mingshun , Cheng Rui 
Published: May 2020

AbstractBronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in preterm neonates. Extracellular matrix (ECM) abnormalities reshape lung development, contributing to BPD progression. In the present study, we first discovered that the ECM component fibronectin was reduced in the pulmonary tissues of model mice with BPD induced by lipopolysaccharide (LPS) and hyper-oxygen. Meanwhile, interleukin-33 (IL-33) and other inflammatory cytokines were elevated in BPD lung tissues. LPS stimulated the production of IL-33 in alveolar epithelial cells via myeloid differentiation factor 88 (MyD88), protein 38 (p38), and nuclear factor-kappa B (NF-κB) protein 65 (p65). Following the knockout of either IL-33 or its receptor suppression of tumorigenicity 2 (ST2) in mice, BPD disease severity was improved, accompanied by elevated fibronectin. ST2 neutralization antibody also relieved BPD progression and restored the expression of fibronectin. IL-33 induced the formation of neutrophil extracellular traps (NETs), which degraded fibronectin in alveolar epithelial cells. Moreover, DNase-mediated degradation of NETs was protective against BPD. Finally, a fibronectin inhibitor directly decreased fibronectin and caused BPD-like disease in the mouse model. Our findings may shed light on the roles of IL-33-induced NETs and reduced fibronectin in the pathogenesis of BPD.