bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmenting Critical Care Patient Monitoring Using Wearable Technology: Review of Usability and Human Factors
Authors: Andrade Evismar , Quinlan Leo , Harte Richard , Byrne Dara , Fallon Enda , Kelly Martina , Casey Siobhan , Kirrane Frank , O'Connor Paul , O'Hora Denis , Scully Michael , Laffey John , Pladys Patrick , Beuchée Alain , ÓLaighin Gearoid 
Published: November 2020

Background
Continuous monitoring of the vital signs of critical care patients is an essential component of critical care medicine. For this task, clinicians use a patient monitor (PM), which conveys patient vital sign data through a screen and an auditory alarm system. Some limitations with PMs have been identified in the literature, such as the need for visual contact with the PM screen, which could result in reduced focus on the patient in specific scenarios, and the amount of noise generated by the PM alarm system. With the advancement of material science and electronic technology, wearable devices have emerged as a potential solution for these problems. This review presents the findings of several studies that focused on the usability and human factors of wearable devices designed for use in critical care patient monitoring.

Objective
The aim of this study is to review the current state of the art in wearable devices intended for use by clinicians to monitor vital signs of critical care patients in hospital settings, with a focus on the usability and human factors of the devices.

Methods
A comprehensive literature search of relevant databases was conducted, and 20 studies were identified and critically reviewed by the authors.

Results
We identified 3 types of wearable devices: tactile, head-mounted, and smartwatch displays. In most cases, these devices were intended for use by anesthesiologists, but nurses and surgeons were also identified as potentially important users of wearable technology in critical care medicine. Although the studies investigating tactile displays revealed their potential to improve clinical monitoring, usability problems related to comfort need to be overcome before they can be considered suitable for use in clinical practice. Only a few studies investigated the usability and human factors of tactile displays by conducting user testing involving critical care professionals. The studies of head-mounted displays (HMDs) revealed that these devices could be useful in critical care medicine, particularly from an ergonomics point of view. By reducing the amount of time the user spends averting their gaze from the patient to a separate screen, HMDs enable clinicians to improve their patient focus and reduce the potential of repetitive strain injury.

Conclusions
Researchers and designers of new wearable devices for use in critical care medicine should strive to achieve not only enhanced performance but also enhanced user experience for their users, especially in terms of comfort and ease of use. These aspects of wearable displays must be extensively tested with the intended end users in a setting that properly reflects the intended context of use before their adoption can be considered in clinical settings.
Effects of Erythropoietin Payment Policy on Cardiovascular Outcomes of Peritoneal Dialysis Patients: Observational Study
Authors: Hou Ying-Hui , Yang Feng-Jung , Lai I-Chun , Lin Shih-Pi , Wan Thomas TH , Chang Ray-E 
Published: November 2020

BackgroundThe change in the reimbursement policy of erythropoietin administration to patients receiving peritoneal dialysis by the Taiwan National Health Insurance (NHI) system provided a natural experimental venue to examine whether cardiovascular risk differs when maintaining the hematocrit (Hct) level below or above 30%.ObjectiveThe aim of this study was to analyze the impact of loosening the erythropoietin payment criteria for peritoneal dialysis patients on their cardiovascular outcomes.MethodsTwo cohorts of incident peritoneal dialysis patients were identified according to the time before and after relaxation of the NHI’s erythropoietin payment criteria, designated cohort 1 (n=1759) and cohort 2 (n=2981), respectively. The cohorts were matched according to propensity scores (1754 patients in each cohort) and then followed up for cardiovascular events, which were analyzed with Cox regressions.ResultsFor the composite cardiovascular endpoint, patients in cohort 2 had a significantly lower risk than those in cohort 1. However, subgroup analysis showed that this risk reduction was observed only in patients with diabetes.ConclusionsAfter loosening erythropoietin payment criteria, reduced cardiovascular risks were observed, particularly for patients with diabetes. These results indicate that it is crucial to maintain an Hct level above 30% to reduce the cardiovascular risk in patients with diabetes undergoing peritoneal dialysis.
Temporal Design Patterns for Digital Phenotype Cohort Selection in Critical Care: Systematic Literature Assessment and Qualitative Synthesis
Authors: Capurro Daniel , Barbe Mario , Daza Claudio , Santa Maria Josefa , Trincado Javier 
Published: November 2020

Background
Inclusion criteria for observational studies frequently contain temporal entities and relations. The use of digital phenotypes to create cohorts in electronic health record–based observational studies requires rich functionality to capture these temporal entities and relations. However, such functionality is not usually available or requires complex database queries and specialized expertise to build them.

Objective
The purpose of this study is to systematically assess observational studies reported in critical care literature to capture design requirements and functionalities for a graphical temporal abstraction-based digital phenotyping tool.

Methods
We iteratively extracted attributes describing patients, interventions, and clinical outcomes. We qualitatively synthesized studies, identifying all temporal and nontemporal entities and relations.

Results
We extracted data from 28 primary studies and 367 temporal and nontemporal entities. We generated a synthesis of entities, relations, and design patterns.

Conclusions
We report on the observed types of clinical temporal entities and their relations as well as design requirements for a temporal abstraction-based digital phenotyping system. The results can be used to inform the development of such a system.
Accountable Care Organizations and Spending for Patients Undergoing Long-Term Dialysis
Authors: Bakre Shivani , Hollingsworth John M. , Yan Phyllis L. , Lawton Emily J. , Hirth Richard A. , Shahinian Vahakn B. 
Published: November 2020

Background and objectives
Despite representing 1% of the population, beneficiaries on long-term dialysis account for over 7% of Medicare’s fee-for-service spending. Because of their focus on care coordination, Accountable Care Organizations may be an effective model to reduce spending inefficiencies for this population. We analyzed Medicare data to examine time trends in long-term dialysis beneficiary alignment to Accountable Care Organizations and differences in spending for those who were Accountable Care Organization aligned versus nonaligned.

Design, setting, participants, & measurements
In this retrospective cohort study, beneficiaries on long-term dialysis between 2009 and 2016 were identified using a 20% random sample of Medicare beneficiaries. Trends in alignment to an Accountable Care Organization were compared with alignment of the general Medicare population from 2012 to 2016. Using an interrupted time series approach, we examined the association between Accountable Care Organization alignment and the primary outcome of total spending for long-term dialysis beneficiaries from prior to Accountable Care Organization implementation (2009–2011) through implementation of the Comprehensive ESRD Care model in October 2015. We fit linear regression models with generalized estimating equations to adjust for patient characteristics.

Results
During the study period, 135,152 beneficiaries on long-term dialysis were identified. The percentage of long-term dialysis beneficiaries aligned to an Accountable Care Organization increased from 6% to 23% from 2012 to 2016. In the time series analysis, spending on Accountable Care Organization–aligned beneficiaries was $143 (95% confidence interval, $5 to $282) less per beneficiary-quarter than spending for nonaligned beneficiaries. In analyses stratified by whether beneficiaries received care from a primary care physician, savings by Accountable Care Organization–aligned beneficiaries were limited to those with care by a primary care physician ($235; 95% confidence interval, $73 to $397).

Conclusions
There was a substantial increase in the percentage of long-term dialysis beneficiaries aligned to an Accountable Care Organization from 2012 to 2016. Moreover, in adjusted models, Accountable Care Organization alignment was associated with modest cost savings among long-term dialysis beneficiaries with care by a primary care physician.
Industria 4.0 en América Latina: Una ruta para su implantación
Authors: Chacón-Ramírez Edgar Alfonso , Cardillo-Albarrán Juan José , Uribe-Hernández Julián 
Published: November 2020

El concepto de Industria 4.0 (I4.0) es muy reciente y su aplicación crea grandes expectativas, aunque no se ha podido medir su impacto de sus resultados. En Europa, EEUU, y países del extremo oriente las grandes empresas lideran su implantación conforme a estándares de automatización. Un caso distinto son las Pequeña y Medianas Empresas (PyMEs), las cuales confrontan problemas que van desde desconocimiento de la tecnología, estructuras empresariales rígidas, formación de recurso humano, falta de estándares lo que crea un gran riesgo para ellas en su incorporación o el riesgo de quedar fuera del cambio. En América Latina el reto es aún mayor, ya que las industrias están en desventaja por su falta de automatización, y más aún en las PyMEs para las cuales I4.0 representa un riesgo. En este trabajo se presenta un esquema de apoyo a la implantación de Industria 4.0, adaptada a la realidad de la industria Latino Americana que incluye una ruta de trabajo para las implantar I 4.0 en PyMEs.
Prognostic factors for the success of obtaining spermatozoa with a biopsy of testicular tissue in men with severe forms of pathozoospermia
Authors: Яманди Т.А. , Сафина Н.Ю. , Черных В.Б. , Акуленко Л.В. 
Published: November 2020

Приводятся данные обследования мужчин с азооспермией и олигозооспермией тяжелой степени, имеющих и не имеющих микроделеции длинного плеча Y-хромосомы, а также результаты биопсии тестикулярной ткани. Отсутствие делеций региона AZF, отсутствие гипоплазии яичек, а также нормальные показатели ФСГ, ЛГ и ингибина В являются прогностически благоприятными критериями в отношении успешности получения сперматозоидов при биопсии ткани яичка для проведения экстракорпорального оплодотворения (ЭКО).
The article presents the results of a survey of men with azoospermia and severe oligozoospermia, with and without microdeletion of the long arm of the Y chromosome, as well as the results of a testicular biopsy. The absence of deletions of the AZF region, the absence of testicular hypoplasia, as well as normal levels of FSH, LH and inhibin B are prognostically favorable criteria for the success of obtaining spermatozoa with a biopsy of testicular tissue for in vitro fertilization (IVF).
Prescriptions (!!) pour maîtriser la prise de parole en public
Authors: Gaiddon Gérard 
Published: November 2020

A défaut de pouvoir bénéficier d’un entraînement et de conseils personnalisés – ce qui est bien entendu le plus souhaitable – le lecteur trouvera ici quelques-unes des notions les plus importantes pour réussir sa prise de parole en public.Il s’agit pour lui de maîtriser rapidement l’essentiel : se familiariser avec les différentes méthodes de préparation, mentale comme émotionnelle, apprendre à gérer au mieux son intervention grâce à une prise de contact adaptée, maîtriser sa communication avec le public, capter son attention, puis la retenir en mobilisant toujours son intérêt.Dans ce but, nous proposons une approche la plus pragmatique possible : une manière de « check-list » que le lecteur pourra aisément mémoriser.Chacun des points abordés ici pourra naturellement être approfondi, complété, enrichi au gré de vos propres expériences, car on n’apprend jamais mieux que par soi-même.
Abstract
Without being able to benefit from training and personalized advice - which is of course the most suitable - the reader will find here some of the most important concepts for delivering successful lectures.It is a matter of quickly mastering the essential: to become familiar with the various methods of preparation, mental as well as emotional, to learn how to manage his / her intervention as best as possible through appropriate contact, to master his/her) communication with the public, to capture his attention, then retain it by always mobilizing its interest.For this purpose, we propose the most pragmatic approach possible: a «checklist» that the reader can easily memorize.Each of the points discussed here can of course be deepened, completed, enriched according to the reader/future speaker’s own experiences, as we never learn better than by ourselves.
The Telemedicine applied to the follow up of patients with End Stage Renal Failure
Authors: SIMON Pierre 
Published: November 2020

Abstract
In the 21st century, renal failure is a chronic disease that affects several millions people in France and around 600 millions worldwide. Its prevalence in the general population increases with the lengthening of the life expectancy that characterizes the developed countries and which begins to appear in the developing countries. Chronic hemodialysis is a treatment that saved many children and young adults in the 20th century whose kidneys were destroyed by several infectious and toxic agents and by untreated malignant hypertension. These causes have been controlled by hygiene measures, anti-infective agents or protective pharmacological agents of the cardiovascular system. Today the causes of end stage renal failure are dominated by degenerative diseases due to aging, such as diabetes and chronic vascular disease. The prevention of the worsening of chronic renal failure is now possible due to better control of high blood pressure and diabetes which are the two main causes of kidney destruction. Hemodialysis treatment cannot always be relayed by renal transplantation. Many patients remain on chronic hemodialysis until they die. It is important to adapt the conditions of treatment to the social life of patients affected by this chronic disease so that these are the best possible. This is the goal of telemedicine that allows to remotely monitor the main clinical and biological factors associated with the worsening of the disease. Teledialysis (hemodialysis and peritoneal dialysis) allows to perform dialysis sessions at home or at the nearest in home substitutes (nursing home) or in satellite units of hemodialysis. Similarly, when the patient is transplanted, it makes possible to either lighten or intensify the surveillance according to the risk or not of graft rejection through home teleconsultation.The tools of the digital era such as telemedicine, health connected with connected objects and mobile apps for medical purposes, the performance of which is increasing with the algorithms of artificial intelligence (machine learning, deep learning), can improve the relationship between the patient and his doctor. An ethical reflection must be associated with all these innovations. New exercise of the medicine will be greatly enriched due to medical time more devoted to the relationship with the patient. The new care organizations made possible by digital technologies must be taught to the new generations of nephrologists.
Relation between dialysis dose and quality of life of patients on peritoneal dialysis
Authors: AL BORGI Yassine , El Alaoui Amina , Benlachhab Zineb , Toutti Wiam , SaghirBahah Mohamed , Jerghich Khadija , Ghita Bardai , Amal Chouhani Basmat , Kabbali Nadia , El Rhazi Karima , Sqalli Tarik 
Published: November 2020

ObjectiveThe interest of our work is to identify the objective parameters that can improve the subjective parameters of the well-being of the patients and to share the experience of the care in our center. Kt / V urea and KDQOL SF 36 scale (Kidney Disease Quality of Life short form 36)were used.
Material and methodsThis is a single-center cross-sectional study conducted in October 2018 among patients treated with peritoneal dialysis, followed for at least six months in the Nephrology Department of Fez University Hospital (Morocco). The quality of life was assessed using the SF-36 (short form) version of the Kidney Disease Quality of Life (KDQOL) scale in its validated Arabic dialect version (1). We used the KDQOL-SF36 results as quantitative variables related to obtaining a Kt / V> 1.7.
ResultsThis study included 17 adult patients on peritoneal dialysis of which 35.3% are on automated peritoneal dialysis (APD) and 64.7% are on continuous ambulatory peritoneal dialysis (CAPD). The mean age is 40.8 ± 5 years and the sex ratio is 9H / 8F.
In bivariate analysis, we found a significant relationship between dialysis dose and social support. This result could be explained by better adherence in patients with better social support.
ConclusionEfforts must be made to achieve the adequacy goals, without losing sight of patients’ quality of life. There is also a need for further studies that include more patients and study other parameters such as clinical evaluation, residual renal function and ultrafiltration.

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Réaliser des tableaux de bord avec le logiciel R
Authors: Della Vedova Claire 
Published: November 2020

Résumé
NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.
Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .
Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Le troisième article était consacré à la visualisation graphiques avec le Package ggplot2 : https://doi.org/10.25796/bdd.v2i4.52303
Le quatrième article expliquait comment générer un rapport d’analyse automatiquement, et de façon dynamique, en utilisant “Rmarkdown” : https://doi.org/10.25796/bdd.v3i1.54523
Ce cinquième article est consacré à la manipulation des données avec le package dplyr : https://doi.org/10.25796/bdd.v3i1.54523
Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.

Biographie de l'auteur

Claire Della Vedova, 1087 chemin de Sainte Roustagne, 04100 MANOSQUE, France

Claire Della Vedova est Ingénieure en biostatistique / data analyste, Elle utilise quotidiennement le logiciel R pour analyser des données. Elle a travaillé pendant plus de 15 ans dans les domaines de l’environnement et de la santé, et a formé de nombreux étudiants et chercheurs à l’utilisation de R. Elle anime depuis novembre 2017 le blog Statistique et Logiciel R dont le but est d’aider les débutants à mieux appréhender les méthodes statistiques classiques et à utiliser le logiciel R plus efficacement, notamment au travers de tutoriels : https://statistique-et-logiciel-r.com/.
Non-invasive assessment of peritoneal membrane alterations
Authors: Krediet Raymond , Parikova Alena 
Published: November 2020

The peritoneal dialysis membrane is subject to remodelling in the course of peritoneal dialysis. In the absence of longitudinal morphological studies, this process is mainly studied indirectly by the investigation of changes in peritoneal transport. Non-invasive assessment of the peritoneum is also possible by assessment of substances that originate from peritoneal tissues and can be determined either as their gene expression in peritoneal effluent cells and/or as proteins in peritoneal effluent. Three of these biomarkers will be discussed, because longitudinal data are available.
Cancer antigen 125 (CA 125) is present on the mesothelium,while its gene (MUC 16) is expressed in peritoneal effluent cells and is related to dialysate CA 125 protein. The constitutive production and the small intra-individual variability of 15% indicate its usefulness as a follow-up marker of mesothelial cell mass. Dialysate appearance rate is higher on biocompatible than on conventional solutions, but both decrease during long-term follow-up.
Interleukin-6 (Il-6) is present in peritoneal effluent due to both transport from the circulation and local intraperitoneal production. Its appearance rate is unrelated to its gene expression in peritoneal cells. The intra-individual variation of effluent Il-6 averages 28%, hampering the interpretation of cross-sectional values. The relationships between effluent Il-6 and peritoneal transport have been interpreted as microinflammation, but are difficult to interprete due to mathematical coupling.
Plasminogen activator inhibitor-1 (PAI-1) is encoded by the SERPINE 1 gene. A relationship is present between effluent concentration and gene expression. PAI-1 production is stimulated by glucose. PAI-1 appearance rate increases with PD duration. The sensitivity of effluent PAI-1 for the diagnosis of encapsulating peritoneal sclerosis was 100% one year prior to the diagnosis and the specificity 56%.
It can be concluded that the discussed biomarkers are useful extensions to transport in assessment of the peritoneum during dialysis.
PERLINDUNGAN HUKUM TERHADAP KONSUMEN MUSLIM DARI PRODUK PANGAN YANG TIDAK BERLABEL HALAL DALAM PERSPEKTIF HUKUM POSITIF YANG TERKAIT DI INDONESIA DAN DI KOREA
Authors: ANGRIYANI ARI MARIYANA 
Published: November 2020

Label halal merupakan bentuk tulisan pernyataan halal untuk menunjukkan bahwa produk yang dimaksud berstatus halal. Label halal berfungsi sebagai perlindungan konsumen agar hak kosumen muslim untuk mengkonsumsi produk halal terjamin. Indonesia sebagai negara dengan penduduk mayoritas Muslim sangat menjaga nilai halal suatu produk, terutama makanan. Belakangan ini banyaknya produk yang belum bersertifikat halal mengakibatkan konsumen muslim kesulitan untuk membedakan antara produk yang halal dan yang tidak halal untuk di konsumsi. Munculnya berbagai produk makanan asing dari berbagai negara telah menjadi hal yang lumrah bagi masyarakat. Namun, pada kenyataannya produk yang beredar di Indonesia tidak terjamin kehalalannya sehingga perlu pengawasan agar produk yang tidak halal, tidak dapat beredar dan dikonsumsi oleh masyarakat Muslim Indonesia. Tujuan penulisan jurnal ini untuk menjelaskan upaya perlindungan hukum terhadap konsumen muslim dari produk pangan yang tidak berlabel halal dalam perspektif hukum positif di Indonesia dan di Korea. Metode yang digunakan mengacu kepada peraturan perundang-undangan. Data yang diperoleh dianalisa dengan cara kualitatif. Berdasarkan hasil penelitian, regulasi yang berkaitan dengan produk Halal masih sangat minim. Oleh karena itu, dalam pengaturan perdagangan Korea disebutkan bahwa: “Acceptance of agency for commercial transactions”, yang berarti: Korea memberikan kebebasan kepada setiap agen untuk melakukan transaksi perdagangan termasuk dengan pemberian label halal pada produknya. Bentuk perlindungan konsumen bagi konsumen muslim adalah Sertifikasi halal.
Kata Kunci: Label halal, Konsumen Muslim, Perlindungan Konsumen.