bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health and quality of life among healthcare professionals during the COVID‐19 pandemic in India
Authors: Suryavanshi Nishi , Kadam Abhay , Dhumal Gauri , Nimkar Smita , Mave Vidya , Gupta Amita , Cox Samyra R. , Gupte Nikhil 
Published: September 2020

AbstractBackgroundThe COVID‐19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health and quality of life (QoL) of Indian HCPs, the fourth highest‐burden country for COVID‐19.MethodUsing snowball sampling, we conducted an online survey in May 2020 among HCPs. Data were collected on demographics, depression, and anxiety using validated tools, quality of life, and perceived stressors. Multivariable logistic regression and principal component analysis were performed to assess risk factors associated with mental health symptoms.FindingsOf 197 HCPs assessed, 157 (80%) were from Maharashtra, 130 (66%) from public hospitals, 47 (24%) nurses, 66 (34%) physicians, 101 (52%) females, and 81 (41%) ≤30 years. Eighty‐seven percent provided direct COVID‐19 care with 43% caring for >10 patients/day. A large proportion reported symptoms of depression (92, 47%), anxiety (98, 50%), and low QoL (89, 45%). Odds of combined depression and anxiety were 2.37 times higher among single HCPs compared to married (95% CI: 1.03–4.96). Work environment stressors were associated with 46% increased risk of combined depression and anxiety (95% CI: 1.15–1.85). Moderate to severe depression and anxiety were independently associated with increased risk of low QoL [OR: 3.19 (95% CI: 1.30–7.84), OR: 2.84 (95% CI: 1.29–6.29)].ConclusionOur study demonstrated a high prevalence of symptoms of depression and anxiety and low QoL among Indian HCPs during the COVID‐19 pandemic. There is an urgent need to prevent and treat mental health symptoms among frontline HCPs.
Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
Authors: Aghayan Seyed Shahrokh , Farajzadeh Asghar , Bagheri‐Hosseinabadi Zahra , Fadaei Homeyra , Yarmohammadi Maryam , Jafarisani Moslem 
Published: September 2020

AbstractBackground and ObjectivePatients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and catabolism of serotonin via monoamine oxidase. The aim of the present study was to evaluate serum homocysteine concentration and its relationship with oxidative stress level in PD patients, regarding homocysteine as a diagnostic biomarker of heart disease.Materials & MethodSixty patients with PD according to the DSM‐5 diagnostic criteria for a panic attack and 60 healthy individuals were included in the present study.Peripheral venous blood samples were taken from patients. Erythrocytes and serum were separated from blood, and RBC hemolysates were prepared to investigate oxidative stress indices including glutathione and glutathione peroxidase. Serum homocysteine and carbonyl groups concentrations were measured in all samples. Data were analyzed using ANOVA, and p < .05 was considered significant.ResultsResults showed that serum carbonyl groups concentration was significantly higher in patients with PD than in healthy individuals (p < .001). The results also indicated decreased serum glutathione concentration and glutathione peroxidase activity in patients (p < .003). In addition, elevated homocysteine concentration in PD patients serum was observed during the present study (p < .003).ConclusionOur findings support that patients with PD experience higher levels of oxidative stress, due to impaired serotonin metabolism, which is related to the prognosis of heart disease in these patients.
How to respond to competitors' green success for improving performance: The moderating role of organizational ambidexterity
Authors: Zhao Wenwen , Feng Taiwen , Xin Xuexiang , Hao Guangyi 
Published: September 2020

AbstractWith increasing environmental competitions between companies, there is a pressing need to explore how the environmental pressures from rivals influence focal firms' actions and the subsequent performance consequences. On the basis of social contagion theory and upper echelons theory, we examine whether firms respond to competitors' green success through green supplier integration, which further improves firm performance, and the moderating effect of organizational ambidexterity. The research explores hypothesized relationships adopting hierarchical regression analysis and bootstrapping method by collecting survey data from 206 Chinese manufacturers. Our findings suggest that competitors' green success positively influences green supplier integration. Green supplier integration mediates the impacts of competitors' green success on financial and environmental performance. In addition, the combined dimension of organizational ambidexterity plays a positive moderating role in the impacts of green supplier integration on financial and environmental performance. This study expands previous literature and managers' practices on green supply chain management.
Business‐oriented environmental regulation: Measurement and implications for environmental policy and business strategy from a sustainable development perspective
Authors: Martínez Hernández Juan J. , Sánchez‐Medina Patricia S. , Díaz‐Pichardo René 
Published: September 2020

AbstractBusiness‐oriented environmental regulation is expected to have a fundamental role in mitigating the adverse effects of human activity on the natural environment. However, its effectiveness and efficiency are not well established. A systematic literature review reveals validity and reliability problems in the measurement of business‐oriented environmental regulation. From a sustainable development perspective, we develop a theoretical framework that aims to enhance the measurement and assessment of this kind of regulation. Our theoretical framework proposes that the goals of business‐oriented environmental regulation must articulate a measurement system in a 3 × 3 matrix: three measurement levels (stringency, response, and outcome—in this cause–effect order) and three sustainability dimensions (environmental, social, and economic—in this constraint order). For each cell, we propose a combination of objective and subjective indicators. This theoretical framework expands existing approaches to business‐oriented environmental regulation measurement by integrating a sustainable development perspective into a measurement framework in a structured theory‐driven manner. Not only will this measurement system be useful for improving environmental policy, but it will also allow companies to improve their business strategy and come closer to complying with environmental regulations in order to effectively contribute to solutions for current environmental problems and help achieve a sustainable development.
Comprehensive analysis on the expression levels and prognostic values of LOX family genes in kidney renal clear cell carcinoma
Authors: Lin Shitong , Zheng Lingling , Lu Yuchao , Xia Qidong , Zhou Peng , Liu Zheng 
Published: September 2020

AbstractBackgroundsKidney renal clear cell carcinoma (KIRC) is a major pathological type of renal cell carcinoma (RCC), and the prognosis of advanced KIRC patients is often unsatisfactory. Some lysine oxidase (LOX) family genes have been proven to be upregulated in some malignancies and play pivotal roles in the carcinogenesis. However, their roles in KIRC remain unclear.Materials and MethodsHere, we used some online databases (eg, ONCOMINE, GEPIA, UALCAN, c‐BioPortal, Human Protein Altas) to comprehensively explored the expression levels and the prognostic values of LOX family genes in KIRC using bioinformatic methods.ResultsThe results revealed that lysyl oxidase (LOX) and lysyl oxidase‐like 2 (LOXL2) were significantly overexpressed in KIRC at the level of mRNA expression, protein expression, and RCC cell lines. Further analysis demonstrated that higher mRNA expression of LOX and LOXL2 were significantly correlated with poor survival, tumor grade, individual cancer stages, and nodal metastasis status. DNA copy number amplifications and mRNA upregulation, DNA deep deletion, and mRNA upregulation were the main genetic mutations of LOX and LOXL2, respectively. Prognostic analysis showed that the altered group had significantly poorer overall survival (OS) compared to the unaltered group (p = .0387). Co‐expression analysis showed CP, PLOD2, and COL5A1 were significantly correlated with LOX, and COL1A2 was positively correlated with LOXL2. Further analysis confirmed that these co‐expressed genes were significantly upregulated and predicted unfavorable prognosis in KIRC.ConclusionMulti‐level analysis demonstrated that LOX and LOXL2 were significantly upregulated and predicted poor survival in KIRC, which may apply as promising biomarkers for diagnosis and therapy of KIRC in the future.
Emotion‐focused therapy for symptoms of generalised anxiety in a student population: An exploratory study
Authors: O’Connell Kent Julie Anne , Jackson Aaron , Robinson Mark , Rashleigh Chuck , Timulak Ladislav 
Published: September 2020

AbstractAnxiety issues continue to retain the highest prevalence rates within student counselling services (SCS) with generalised anxiety a prominent concern. These issues are associated with poor academic achievement, attrition and self‐injurious behaviours. Cognitive behavioural therapy (CBT) is moderately effective in treating generalised anxiety in students. Initial studies of emotion‐focused therapy (EFT) for GAD are indicating successful outcomes for clients though research investigating a brief format within SCS populations is needed.AimThe present exploratory study represents an early effort to examine the effectiveness of brief EFT for generalised anxiety symptoms within a university SCS and the clients’ experiences of this type of therapy.MethodParticipants (n = 15) presenting to a SCS with worry and generalised anxiety symptoms received an individual EFT for GAD intervention. Outcomes were assessed using two outcome measures pre‐ and post‐therapy and a semi‐structured post‐therapy interview examined the clients’ experiences of therapy and its outcomes.ResultsQuantitative pre–postdata indicated large effect sizes. Qualitative data described experiences of decreased anxiety, increased self‐understanding, resilience, self‐compassion and assertiveness. Experiential work and the therapeutic relationship were experienced as helpful aspects of therapy though experiential work was difficult. Personal difficulty engaging in therapy and some remaining symptoms were unhelpful aspects.ConclusionFindings suggest that brief EFT for generalised anxiety symptoms in students may be an effective SCS intervention and warrants further investigation.
Efficiency of grain cleaner to increase test weight in wheat (Triticum aestivum)
Authors: Crépon Katell , Duyme Florent 
Published: September 2020

AbstractBackground and objectivesWeather conditions can deteriorate the test weight to the extent that some wheat lots see their access to the market compromised. Test weight degradation may be due to low grain density or to an alteration in packing characteristics, in particular because of a high level of impurities in the batch. Therefore, grain cleaning can improve test weight by removing impurities. The objective of this work was to determine the settings of the cleaner that significantly influence both the improvement of test weight and the amount of materials removed by cleaning, in order to advise silo managers on the cleaning strategy to adopt in case of low‐test weight harvest.FindingsWe implemented a complete factorial design of experiments using a laboratory cleaner‐separator. The factors tested were the initial test weight, the screens used, the aspiration, and the grain flow rate.ConclusionsCleaning significantly improve test weight by an average of 2.1 kg/hl. The average amount of material removed is 8.1%. The only setting that significantly impacts the test weight gain is the grain flow rate. Using a more open screen does not affect test weight gain but greatly increases screenings, so this strategy should be avoided.Significance and noveltyAs a result of this work, two decision trees guide the choice of the operators as regards the adjustment of the devices according to the expected specific weight gain and the amount of lost material caused.
Branch Duct – IPMN and PanIN, in IgG4‐Autoimmune pancreatitis: A case report
Authors: Lazzarin Gianni , Romano Lucia , Coletti Gino , Di Sibio Alessandra , Vicentini Vincenzo , Fatayer Mohamad W. Alid , Schietroma Mario , Pessia Beatrice , Leone Matteo , Carlei Francesco , Giuliani Antonio 
Published: September 2020

AbstractThe presence of pancreatic lesions in patients with autoimmune pancreatitis requires histological diagnosis (percutaneous or endoscopic biopsy) to exclude malignancy. A nonspecific histology after endoscopic or percutaneous biopsy of a pancreatic lesion may require surgical excision and definite histology.
Aquagenic urticaria: Water, friend, or foe?
Authors: Robles‐Tenorio Arturo , Tarango‐Martinez Victor Manuel , Sierra‐Silva Georgina 
Published: September 2020

AbstractThere are <100 reported cases of aquagenic urticaria. Although most are sporadic, several diseases have been associated. Diagnosis is based on provocation tests. Second‐generation antihistamines are the first‐line treatment.
Diagnostic benefit of cytological and histopathological examinations for recurrent vaginal cancer metastasizing to the duodenum: A case report
Authors: Sonoda Kenzo , Okadome Masao , Sugimoto Rie , Fujimoto Takahiro , Taguchi Kenichi , Saito Toshiaki 
Published: September 2020

AbstractThis is the first case report of a vaginal squamous cell carcinoma that metastasized to the duodenum. Cytological and histopathological examinations are useful for the diagnosis of a duodenal metastasis.
The lambda sign in gallium‐67 scintigraphy is a useful clue to the early diagnosis of sarcoidosis
Authors: Hisata Yoshio , Tago Masaki , Fujiwara Motoshi , Yamashita Shu‐ichi 
Published: September 2020

AbstractA 40‐year‐old man with bilateral hilar lymphadenopathy in chest X‐ray and the λ‐sign in gallium‐67 scintigraphy was subsequently diagnosed with systemic sarcoidosis according to the findings of bronchoalveolar lavage and histopathological examinations of transbronchial lung biopsies. Identifying the λ‐sign could be a valuable clue to the early diagnosis of sarcoidosis.
Metastatic squamous cell carcinoma in a cervical lymph node
Authors: Bloomer Zachary W. , Snitchler Andrea N. , Shakir Mohamed K. M. , Hoang Thanh D. 
Published: September 2020

AbstractCervical lymphadenopathy is a very common complaint for patients presenting to an endocrinology clinic. This case highlights common locations that malignancy presents at as well as their ultrasound characteristics.
Design and operando/in situ characterization of precious‐metal‐free electrocatalysts for alkaline water splitting
Authors: Zhao Tingwen , Wang Yuan , Karuturi Siva , Catchpole Kylie , Zhang Qiang , Zhao Chuan 
Published: September 2020

AbstractElectrochemical water splitting has attracted considerable attention for the production of hydrogen fuel by using renewable energy resources. However, the sluggish reaction kinetics make it essential to explore precious‐metal‐free electrocatalysts with superior activity and long‐term stability. Tremendous efforts have been made in exploring electrocatalysts to reduce the energy barriers and improve catalytic efficiency. This review summarizes different categories of precious‐metal‐free electrocatalysts developed in the past 5 years for alkaline water splitting. The design strategies for optimizing the electronic and geometric structures of electrocatalysts with enhanced catalytic performance are discussed, including composition modulation, defect engineering, and structural engineering. Particularly, the advancement of operando/in situ characterization techniques toward the understanding of structural evolution, reaction intermediates, and active sites during the water splitting process are summarized. Finally, current challenges and future perspectives toward achieving efficient catalyst systems for industrial applications are proposed. This review will provide insights and strategies to the design of precious‐metal‐free electrocatalysts and inspire future research in alkaline water splitting.
Sarcaglarols A—D, Lindenane−Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks
Authors: Wang Yongyue , Cui Zhirong , Chi Jun , Tang Pengfei , Zhang Meihui , Li Jixin , Li Yongyi , Zhang Hao , Luo Jun , Kong Lingyi 
Published: September 2020

Main observation and conclusionSarcaglarols A—D (1—4), two pairs of lindenane−monoterpene heterodimers fused by a 1,2‐dioxane moiety, were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking‐based strategy. Their planar structures, absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS, NMR spectroscopic data, ECD spectrum, and the X‐ray diffraction study of isopropylidene derivatives. An intermolecular [2+2+2] cycloaddition may play a key role in the biosynthesis pathway of the 1,2‐dioxane moiety fused lindenane−monoterpene heterodimer skeleton, which can be recognized as the biogenetic precursors of our previous reported lindenane−normonoterpene conjugates. In addition, compounds 1, 3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid‐exposed L02 cells.
FLN‐1/filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub‐cellular organelles in a contractile tissue
Authors: Kelley Charlotte A. , Triplett Olivia , Mallick Samyukta , Burkewitz Kristopher , Mair William B. , Cram Erin J. 
Published: September 2020

AbstractActomyosin networks are organized in space, direction, size, and connectivity to produce coordinated contractions across cells. We use theC. elegansspermatheca, a tube composed of contractile myoepithelial cells, to study how actomyosin structures are organized. FLN‐1/filamin is required for the formation and stabilization of a regular array of parallel, contractile, actomyosin fibers in this tissue. Loss offln‐1results in the detachment of actin fibers from the basal surface, which then accumulate along the cell junctions and are stabilized by spectrin. In addition, actin and myosin are captured at the nucleus by the linker of nucleoskeleton and cytoskeleton complex (LINC) complex, where they form large foci. Nuclear positioning and morphology, distribution of the endoplasmic reticulum and the mitochondrial network are also disrupted. These results demonstrate that filamin is required to prevent large actin bundle formation and detachment, to prevent excess nuclear localization of actin and myosin, and to ensure correct positioning of organelles.
Defect Chemistry on Electrode Materials for Electrochemical Energy Storage and Conversion
Authors: Zhang Yiqiong , Xu Jian , Long Yong , Tao Li , Ding Mei , Jia Chuankun 
Published: September 2020

AbstractEfficient and sustainable clean energy technology is an urgent need to solve energy crisis and alleviate environmental pollution. Reasonable design of electrode materials can effectively improve the performance of electrochemical energy storage and conversion devices. As an effective method to control the properties of electrode materials, defects have recently received extensive attention. Herein, in this review, we will systematically summarize the application of defect chemistry on electrode materials for electrochemical energy storage and conversion. Firstly, we mainly describe the research content of defect chemistry from three aspects, including defect construction, the dynamic evolution and regulation of defects. Based on those understanding, the applications of defect chemistry in fuel cells, metal‐ion batteries and carbon/nitrogen fixation are discussed, respectively. Finally, the existing challenges and future development prospects of defect chemistry are proposed. Overall, we hope this review could help readers to better understand and apply defect chemistry on electrode materials.
Large‐scale Synthesis of Uniform and Shape‐tunable ZnO/Polysiloxane Janus Micromotors Powered by Visible Light and Pure Water
Authors: Xie Wenqing , Zhou Chao , Zhang Xiaoliang , Du Sinan , Wang Wei , Wang Huaguang , Zhang Zexin 
Published: September 2020

AbstractLarge‐scale synthesis of micromotors powered by visible light and pure water is challenging, yet crucial for practical applications. Herein, a new method for large‐scale synthesis of uniform Janus ZnO micromotors is reported, by partially encapsulating a ZnO microsphere within a polysiloxane microsphere. The resulting micromotors autonomously move under visible light and in pure water at speeds up to 15 μm/s. The shapes of these micromotors are readily tuned by adjusting the chemicals used in the synthesis, and the influence of the shapes on the speeds of the micromotors is quantified. Moreover, interesting collective behaviors, such as the formation of dynamic clusters, emerge from a dense population of these micromotors. This study therefore represents a substantial step forward in building an excellent model system of good quantity, uniformity and tunability for the study of active matter as well as in a variety of practical applications.
Predictive implications of decreased CA19‐9 at 8 weeks during nab‐paclitaxel plus gemcitabine for the induction of second‐line chemotherapy for patients with advanced pancreatic cancer
Authors: Iede Kiyotsugu , Yamada Terumasa , Kato Ryo , Ueda Masami , Tsuda Yujiro , Nakashima Shinsuke , Ohta Katsuya , Matsuyama Jin , Ikenaga Masakazu , Tominaga Shusei 
Published: September 2020

AbstractBackgroundSecond‐line (2L) chemotherapy after nab‐paclitaxel plus gemcitabine (AG) is important for improving the survival of patients with advanced pancreatic cancer (APC). However, many patients fail to receive 2L chemotherapy because of rapid disease progression. Therefore, early recognition of any ineffectiveness during AG might lead to an increased induction rate of 2L chemotherapy.AimWe investigated the significance of treatment response at 8 weeks as a predictive factor for the induction of 2L chemotherapy after AG.Methods and resultsFrom January 2015 to January 2019, 41 patients with APC underwent AG as first‐line chemotherapy at our institute. Thirty‐three patients were evaluated at 8 weeks. Sixteen patients (48%) underwent 2L chemotherapy and 17 (52%) underwent no 2L chemotherapy. Clinical features and treatment response at 8 weeks were, retrospectively, compared among patients. Predictive factors for the induction of 2L chemotherapy were analyzed. Patients with an objective response by 8 weeks received 2L chemotherapy more frequently (P = .026). Decreased CA19‐9 (<50%) at 8 weeks was identified as an independent negative predictive factor for the induction of 2L chemotherapy.ConclusionsDecreased CA19‐9 (<50%) at 8 weeks may indicate the ineffectiveness of AG and signify that a move to 2L chemotherapy may be required without delay.