bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic and cardiovascular risk factors associated with drug use in truck drivers
Authors: Pereira Mariana Moura , Mansur Antonio Padua , Takada Julio Yoshio , Leyton Vilma 
Published: April 2020

Abstract

Background: The irregular routine of truck drivers favors the development of chronic noncommunicable diseases (NCDs), especially cardiovascular diseases (CVDs), which can be exacerbated by the use of illicit drugs.Methods: A cross-sectional study was carried out with data from 2,071 truck drivers who traveled through the state of São Paulo between 2010 and 2016. Socioeconomic and occupational variables and risk factors for CVD were associated with drug use. Clinical and toxicological tests were also carried out.Results: The average age of the truck drivers was 42.27 ± 11.07 years, and the use of illicit drugs, at least once while working, was reported or detected in 388 (18.7%) drivers. Compared to non-users, drug users were younger (37.25 ± 9.45 vs. 43.43 ± 11.1 years; p <0.001) and single (43.3% vs. 28.4%; p <0.001). The independent variables age [OR = 0.93 (95% CI: 0.91 - 0.95; p<0.001)], smoking [OR = 2.18 (95% CI: 1.39 - 3.44; p = 0.001)], alcohol consumption [OR = 1.626 (95% CI: 1.06 - 2.49; p = 0.026)] and hours of driving per day [OR = 1.08 (95% CI: 1.01 - 1.15; p = 0.012)] were also associated with the use of illicit drugs.Conclusion: The use of illicit drugs was higher in young and single drivers and was associated with a higher prevalence of smoking, alcohol consumption and more driving hours, which are risk factors for NCDs, CVD and traffic accidents.
The design optimization of Chinese medicinal compound for the treatment of co-infection of Mycoplasma gallisepticum and Escherichia Coli
Authors: Wu Zhiyong , Fan Qianqian , Bao Jiaxin , Li Rui , Ishfaq Muhammad , Li Jichang 
Published: April 2020

Abstract
Background: A new Chinese medicinal compound including Isatdis Radix, Forsythiae Fructus, Mori Cortex, Ginkgo Folium, Licorice and Radix Salviae was pre-screened through the method of network pharmacology for the treatment of co-infection of Mycoplasma gallisepticum and Escherichia Coli. While, the optimal combination of Chinese medicine is still an obstacle to the development of the Chinese medicinal compound.Results: A multi-indicators evaluation method was used in this study to establish a comprehensive assessment system based on the minimal inhibitory concentration of Mycoplasma gallisepticum and Escherichia Coli in vitro, air sac and tracheal lesion scores in vivo. We used the min-max normalization method to normalize the scores of the four metrics and gave them the same proportion of weights to calculate the total score. Then, according to the method of uniform test, the six-factor ten-level experiment (U*10(106) was designed, with the total score as the index. The multi-nonlinear regression equation was established by data processing system according to the comprehensive index. The results showed that the ratio of Isatdis Radix, Forsythiae Fructus, Ginkgo Folium, Mori Cortex, Licorice and Radix Salviae were 14:7:11:12:5:3, which showed effective treatment. Conclusions: It turned out that uniform design can be effectively used to solve dose optimization for combined use of multiple compounds. In addition, this study also proposes a new method to comprehensively evaluate medicinal compounds for respiratory diseases such as Mycoplasma gallisepticum and Escherichia Coli infection.
WITHDRAWN: Differences in the soil bacterial community under organic farming and conventional farming modes revealed by 16S rDNA sequencing
Authors: Yang Yazhen , Fang Mingke , Wu Meiyan , Zhang Huaisheng , Li Huizhen , Zhu Jianqiang 
Published: April 2020

Abstract
Background The bacterial communities is complex and different in various agricultural ecosystem. In this study, high-throughput Illumina MiSeq sequencing was conducted to assess the differences in soil bacterial communities between organic farming and conventional farming modes. Results A total of 3, 919 operational taxonomic units were identified and classified as 26 phyla, 42 classes, 78 orders, 120 families, 281 genera. The dominant genera were Lysobacter , Pseudomonas , Massilia , Pseudarthrobacter , Ferruginibacter , Flavobacterium , Flavisolibacter , Brevundimonas , Haliangium and Sphingomonas . Analysis of soil bacterial diversity showed that the soil under the organic farming had a greater bacterial diversity than that under the conventional farming. Linear discriminant analysis effect size analysis showed that the major bacterial groups identified in the soil sample CK1 (2015.4) and CK6 (2017.10) under conventional farming mode were largely different from those in the soil sample O6 (2017.10) under organic farming mode. Redundancy analysis demonstrated that available nitrogen was the most important factor regulating bacterial composition under the organic farming mode, followed by soil rapidly available phosphorous and potassium. Massilia , Pseudomonas , Lysobacter and Pseudarthrobacter abundances showed a strong positive correlation with the content of available nitrogen. Conclusions Organic farming could improve soil organic matter, available nitrogen, rapidly available phosphorus and retard soil acidification. This modification of soil can directly or indirectly relate to the bacterial communities in soil. The shifts of bacterial communities were complicated and dynamic with respect to all sorts of the measures of cultivation and management under organic farming mode.
CRID3 , a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
Authors: Chen Yu-Qing , Wang Sai-Nan , Shi Yu-Jiao , Chen Jing , Ding Shu-Qin , Tang Jie , Shen Lin , Wang Rui , Ding Hai , Hu Jian-Guo , Lü He-zuo 
Published: April 2020

Abstract
Background: After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflammation following SCI, and apoptosis associated speck like protein containing a card (ASC) is the adaptor protein shared by inflammasomes. Therefore, we speculated that inhibiting ASC may improve the local microenvironment of injured spinal cord. In this study, CRID3, a blocker of ASC oligomerization, was used to study its effect on the local microenvironment and the possible role in neuroprotection following SCI.Methods: Murine SCI model was created using an Infinite Horizon impactor at T9 vertebral level with a force of 50 Kdynes and CRID3 (50 mg/kg) was intraperitoneally injected following injury. ASC and its downstream molecules in inflammasome signaling pathway were measured by western blot. The immune cell subsets were detected by immunohistofluorescence (IHF) and flow cytometry (FCM). The spinal cord fibrosis area, neuron survival, myelin preservation and functional recovery were assessed.Results: Following SCI, CRID3 administration inhibited inflammasome-related ASC and caspase-1, IL-1β and IL-18 activation, which consequently suppressed M1 microglia, Th1 and Th1Th17 differentiation, and increased M2 microglia and Th2 differentiation. Accordingly, the improved histology and behavior also been found.Conclusions: CRID3 may ameliorates murine SCI by inhibiting inflammasome activation, reducing proinflammatory factor production, restoring immune cell subset balance and improving local immune microenvironment, and early administration may be a promising therapeutic strategy for SCI.
Trends in breast cancer incidence in Ho Chi Minh City 1996 - 2015: a registry-based study
Authors: Pham Dung X. , Ho Thao-Quyen H. , Bui Tung D. , Ho-Pham Lan T. , Nguyen Tuan V. 
Published: April 2020

Abstract
Background and Aims: The burden of breast cancer in Vietnam has not been documented. This study sought to estimate the incidence of breast cancer in Ho Chi Minh City, the largest economic center of Vietnam, from 1996 to 2015.Methods: This was a population-based study using the Ho Chi Minh City Cancer Registry as a source of data (coverage period: 1996 - 2015). The Registry adopted the International Classification of Diseases for Oncology, 3rd Edition for the classification of primary sites and morphology, and guidelines from the International Agency for Research on Cancer and the International Association of Cancer Registries. Using the population statistics from census data of Ho Chi Minh City, the point incidence of breast cancer for each 5-year period was estimated. Based on the national population, we calculated the age-standardized rate (ASR) of breast cancer between 1996 and 2015.Results: Overall 14,222 new cases of breast cancer (13,498 women, or 95%) had been registered during the 1996-2015 period; among whom, just over half (52%) were in the 2nd stage, and 26% in the 3rd and and 4th stages. In women, the median age at diagnosis was 50 years and there was a slight increase over time. The age-standardized incidence rate of breast cancer during 2011-2015 period was 21.5 cases per 100,000 women, representing an increase of 70% compared to the rate in 1996-2000 period. In men, there was also a significant increase in the age-standardized incidence rate: from 0.22 during the 1996-2001 period to 0.46 per 100,000 men during the 2011-2015 period.Conclusions: These very first data from Vietnam suggest that although the incidence of breast cancer in Vietnam remains relatively low, it has increased over time, and that the increase was mainly attributable to those age groups of 50 and 70.
Whole-genome sequencing of a Brazilian naturalized horse breed resistant to arid climate for identifying single nucleotide variants and insertions/deletions
Authors: Cardoso Danielle Cunha , Coelho Eduardo Geraldo Alves , Porto Brenda Neves , silva glacy , Pires Denea de Araújo Fernandes , Oliveira Denise Aparecida Andrade de 
Published: April 2020

Abstract
Background: In this study, we perform a search for variants (SNVs and InDels) in the genome of a Brazilian Naturalized horse breed, using FreeBayes and GATK variant calling tools. This breed presents exclusive adaptive traits of extreme importance to semi-arid conditions, such as those that allow survival under excessive sunlight, rainfall, low forage availability and stony ground. Moreover, these traits are expressed without any detriment to the performance and perpetuation of the breed. Results: A total of 305,588,364 reads were mapped in the horse reference genome, 1,598,210 single nucleotide variations and 138,139 insertions/deletions were detected by FreeBayes, 88,838 (SNVs) and 25,232 (InDels) by GATK. Both have been used in order to increase the safety of variant calls, identify in which regions of the genome they are present and check for variants in genes possibly associated with the peculiar traits exhibited by the breed. Conclusions: The variants annotation identified numerous non-synonymous SNVs and frameshift InDels, which could affect phenotypic variation. We found 28 and 392 Emsembl gene IDs containing high and moderate impact SNVs, including GTPase family members, olfactory receptors, mitochondrial complex and defense genes. Functional enrichment analysis was performed and revealed that variants in the olfactory transduction pathway were overrepresented.
Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis
Authors: Wen Fang , Yan Junjuan , Yu Liping , Wang Fang , Liu Jingran , Li Ying , Cui Yonghua 
Published: April 2020

Abstract
Background: Tourette syndrome (TS) is a neurodevelopmental disorder defined by the continual presence of primary motor and vocal tics. Grey matter abnormalities have been identified in numerous studies of TS, but conflicting results have been reported. This study was an unbiased statistical meta-analysis of published neuroimaging studies of TS structures. Methods: A voxel quantitative meta-analysis technique called activation likelihood estimation (ALE) was used.The meta-analysis included six neuroimaging studies involving 247 TS patients and 236 healthy controls. A statistical threshold of p < 0.05 was established based on the false discovery rate and a cluster extent threshold of 50 voxels.Results: We found that grey matter volumes were significantly increased in the bilateral thalamus, right hypothalamus, right precentral gyrus, left postcentral gyrus, left inferior parietal lobule, right lentiform nucleus, and left insula of TS patients compared to those of healthy controls. In contrast, grey matter volumes were significantly decreased in the bilateral postcentral gyrus, bilateral anterior cingulate, bilateral insula, left posterior cingulate, and left postcentral gyrus of TS patients compared to those of healthy controls.Conclusions: Our present meta-analysis primarily revealed significant increases in grey matter volumes in the thalamus and lentiform nucleus, and decreased grey matter volumes in the anterior cingulate gyrus, of TS patients compared to those in healthy controls. Most of these identified regions are associated with cortico-striato-thalamo-cortical circuits. Further studies with larger sample sizes are needed to confirm these changes in grey matter volumes in TS patients.
Sleep and Its Importance for Health-Related Quality of Life in 3–10-year-old Children
Authors: Angelhoff Charlotte , Sundell Anna Lena 
Published: April 2020

Abstract

Purpose Considering the reports of increasing sleep problems in children, affecting health and well-being in young children and their families, we found it important to gain more knowledge about sleep and its correlation to health-related quality of life (HRQoL) in young, healthy children. The aim with this study was to describe sleep quality, sleep duration, and HRQoL in healthy 3–10-year-old children and to test associations between children’s sleep and HRQoL. Methods Parents of 160 children (average age: 6.9 years, SD ±2.2) participated in the study. Sleep onset problems (SOP), sleep maintenance problems (SMP), and sleep duration were measured by the Pediatric Insomnia Severity Index (PISI). KIDSCREEN-27 was used to measure HRQoL in five dimensions: physical well-being, psychological well-being, autonomy and parent relation, social support and peers, and school environment. Results The average score was 2.2 for SOP (SD +/-2.2) and 1.3 for SMP (SD +/-1.6). Almost all children (98%) slept between 8 and 13 hours per night. Younger children had statistically significantly more sleep problems than older children. Correlations were found between SOP and poor psychological well-being ( p < 0.05, ρ = - 0.16), and between SMP and poor psychological well-being ( p < 0.05, ρ = - 0.21), poor school environment ( p < 0.01, ρ = - 0.29), and poor social support and peers ( p < 0.05, ρ = - 0.19). Conclusion Children’s sleep associates with psychosocial well-being, school functioning and relations to peers, and need to be acknowledged in child health care settings and schools.
Prevalence and Socioeconomic inequalities trends in child health comparing within and between group inequalities: Food insecurity and malnutrition in Zimbabwe
Authors: Lukwa Akim Tafadzwa , Siya Aggrey , Zablon Karen Nelwin , Azam James , Alaba Olufunke A. 
Published: April 2020

Abstract
BackgroundInequalities in child health remain a threat to this global efforts to achieve universal health coverage. We assessed socioeconomic inequalities in child health focusing on malnutrition and food insecurity in Zimbabwe.MethodsWe used Demographic Health Survey (DHS) data sets of 2010\11 and 2015. Food insecurity in children was determined based on the WHO dietary diversity score. Minimum dietary diversity was defined by a cut- off point of >4 therefore, in this study children with less than 3 of the 13 food groups were defined as food insecure. Malnutrition was assessed using weight for age Z-score, with children whose weight-for-age Z-score below minus two standard deviations (-2 SD) from the median considered malnourished. Concentration indices were computed to understand if malnutrition was dominant among the poor or rich. The study used the Theil index and decomposed the index by population subgroups (geographical clusters and socioeconomic status).ResultsOver the study period, malnutrition prevalence increased by 1.03 percentage points (p.p) [2010/11(3.73%); 2015(4.76%)], while food insecurity prevalence decreased by 4.35p.p [2010/11(78.29%);2015(73.94)]. Prevalence of malnutrition and food insecurity increased by; 9.6p.p and 2p.p among poor children & 10.23p.p and 0.5p.p among rural children. Children from wealthy households were more likely to be food secure and children from poor households were more likely to be nutritious. For nutrition status, socioeconomic inequality gaps appeared to be widening as the concentration indices between the two time periods increased, while for food security status socioeconomic inequality gaps appeared to be contracting as the concentration indices between the two time periods reduced. Food security status showed contracting socioeconomic inequality gaps in both geographical clusters (urban & rural), while for nutrition status there were widening socioeconomic inequality gaps among urban children and contracting socioeconomic inequality gaps among rural children.ConclusionWithin-group inequalities are driving most of the socioeconomic inequalities in nutritional status and food security status among children in Zimbabwe. There is need for policies that focus on addressing within-group inequalities and direct food security interventions for food insecure children through availing food aid parcels especially for children from poor households irrespective of where they reside.
Recurrence of Positive SARS-CoV-2 Viral RNA in Recovered COVID-19 Patients During Medical Isolation Observation
Authors: Yuan Bo , Liu Han-Qing , Yang Zheng-Rong , Chen Yong-Xin , Liu Zhi-Yong , Zhang Kai , Wang Cheng , Li Wei-Xin , An Ya-Wen , Wang Jian-Chun , Song Shuo 
Published: April 2020

Abstract
Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients get more attention. Here we report a cohort study on the follow up of 182 recovered patients under medical isolation observation. There are 20 (10.99 %) patients out of the 182 were detected SARS-CoV-2 RNA turned positive, but none of them shows any clinical symptomatic recurrence indicating that COVID-19 has a good prognosis. Females and young patients aged under 15 have higher re-positive rate than the average, and none of the severe patients turned re-positive. Notably, most of the re-positive cases turn negative in the followed tests, suggesting that the importance of dynamic surveillance of SARS-CoV-2 RNA for infectivity assessment.
Contractility and electroexcitability of isolated myocardium of right ventricular of rat heart depending on estrous cycle and pregnancy
Authors: Korotaeva Yuliya , Nozdrachev Alexander , Tsyrkin Viktor 
Published: April 2020

It is known that women and rats have increased minute volume of blood flow (MV) during pregnancy. It is believed that this is due to an increase in heart rate. This remains unclear — whether pregnancy increases myocardial contractility (and consequently increases the stroke volume). There are no data on changes of myocardium electroexcitability during pregnancy. To clarify these issues, experiments were conducted on strips of right ventricular of 94 nonpregnant and 45 pregnant rats. The strips were perfused with Krebs solution at 37 °C, which is preenriched by pure oxygen, and after 30 minutes of adaptation evaluated force of contractions. They are caused by electrostimulation (5 ms, 1 Hz, 20 V) applied transmural. Then determined the excitation threshold, i.e, minimum voltage (V), wherein a single stimul (5 ms) induced contraction. It was found that the force of contraction (mN, mN/mg wet weight or mN/mg dry weight of strips ) and the excitation threshold do not depend on the phase of the estrous cycle, pregnancy, and the availability of its terms. This means that during pregnancy contractility of right ventricle of rats myocardial does not change, and even tends to decrease. Therefore, increasing of MV during pregnancy, most likely due to an increase in heart rate. It was also established that at the end of pregnancy water content increases (on 12 %) in the myocardium (perhaps by increasing the expression of aquaporins in cardiomyocytes) which is regarded as a reflection of adaptation. Refs 41. Figs 4.
Decentralized ellipsoidal state estimation for linear model predictive control of an irrigation canal
Authors: Rodriguez L. P. , Maestre J. M. , Camacho E. F. , Sánchez M. C. 
Published: April 2020

AbstractA centralized linear MPC is used to stabilize an irrigation system whose operation is represented by an integrator-delay model. Since not all the state variables can be measured, a decentralized ellipsoidal estimation strategy is proposed. This approach keeps the quality of a centralized estimation and reduces significantly the computation time for the systems considered. An adaptation of Test Canal 1, developed by the ASCE Task Committee on Canal Automation Algorithms, is used as a case study to show the performance of the proposed methodology.
Prediction and analysis of non-stationary runoff extreme sequence based on ESMD combination prediction model
Authors: Li Yi-zhen , Yue Chun-fang 
Published: April 2020

Abstract
With increasingly severe climate changes and intensified human activities, it is more and more difficult to predict the non-stationary extreme runoff series accurately. In this research, based on the ‘decomposition-prediction-reconstruction’ model, an instantaneous frequency distribution map was used to measure the effect of empirical mode decomposition (EMD), ensemble empirical mode decomposition, complete ensemble empirical mode decomposition and extreme-point symmetric mode decomposition (ESMD) in dealing with mode mixing; appropriate prediction methods for each component were selected to form a combined prediction model; and the advantages of a combined prediction model based on ESMD were compared and analyzed with the following results acquired: (1) ESMD can address the mode mixing problem with EMD; (2) particle swarm optimization-least squares support vector machine, autoregressive model (1) and random forest are suitable for high-/medium-/low-frequency components and the residual components R; (3) the results of the combined prediction model are better than those of the single ones; and (4) the prediction effect of the combined prediction model is the best under ESMD decomposition, and the prediction errors of the runoff extreme value sequence can be reduced by about 58–80% compared with the three other decomposition methods. Moreover, as demonstrated in this study, the combined prediction model based on ESMD can effectively predict the non-stationary extreme runoff series, while providing reference for forecasting other non-stationary time series.