bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in preventive care utilisation and its influencing factors among Chinese adults before and after the healthcare reform: cross-sectional evidence from the China Health and Nutrition Survey in 2004–2015
Authors: Wu Ting Ting , Liu Wei Wei , Zou Mao , Lei Xun , Yang Qiang , Sharma Manoj , Zhao Yong , Shi Zu Min 
Published: October 2020

ObjectiveChina launched its health reform in 2009. This study aimed to assess changes in preventive care utilisation (PCU) and its relationship with the healthcare reform.DesignA cross-sectional study using demographic characteristics, socioeconomic status, environmental factors, and lifestyle and health status data of adults from five waves (2004–2015) of the China Health and Nutrition Survey (CHNS) was conducted. Multilevel mixed-effects logistic regression models were used.SettingData were derived from urban and rural communities of nine provinces in China.ParticipantsData were obtained from five waves of the CHNS, with 9960 participants in 2004, 9888 in 2006, 10 286 in 2009, 9709 in 2011, and 10 628 in 2015.OutcomeThe primary outcome was PCU.ResultsPCU in 2004–2015 among adults was 3.29%, 3.13%, 3.77%, 4.95% and 2.73%, respectively. Whether before or after the health reform, having a history of disease and female gender were positive influencing factors of PCU. Before 2009, PCU was significantly associated with gender, income, medical insurance status and region. Age, medical insurance status, history of drinking and education level significantly affected PCU in 2009–2011. Having medical insurance was no longer a positive influencing factor of PCU, while high income had a negative effect on PCU, in 2011–2015.ConclusionsPCU from 2004 to 2015 was low and the health reform in China may lack sustainable effect on PCU. Further studies on how to ensure sustainability of PCU are necessary, and further reforms on preventive care services should be aimed at different ages, rural areas and participants without history of disease.
Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury
Authors: Wrzosek Laura , Ciocan Dragos , Hugot Cindy , Spatz Madeleine , Dupeux Margot , Houron Camille , Lievin-Le Moal Vanessa , Puchois Virginie , Ferrere Gladys , Trainel Nicolas , Mercier-Nomé Françoise , Durand Sylvere , Kroemer Guido , Voican Cosmin Sebastian , Emond Patrick , Straube Marjolène , Sokol Harry , Perlemuter Gabriel , Cassard Anne-Marie 
Published: October 2020

ObjectiveChronic alcohol consumption is an important cause of liver-related deaths. Specific intestinal microbiota profiles are associated with susceptibility or resistance to alcoholic liver disease in both mice and humans. We aimed to identify the mechanisms by which targeting intestinal microbiota can improve alcohol-induced liver lesions.DesignWe used human associated mice, a mouse model of alcoholic liver disease transplanted with the intestinal microbiota of alcoholic patients and used the prebiotic, pectin, to modulate the intestinal microbiota. Based on metabolomic analyses, we focused on microbiota tryptophan metabolites, which are ligands of the aryl hydrocarbon receptor (AhR). Involvement of the AhR pathway was assessed using both a pharmacological approach and AhR-deficient mice.ResultsPectin treatment modified the microbiome and metabolome in human microbiota-associated alcohol-fed mice, leading to a specific faecal signature. High production of bacterial tryptophan metabolites was associated with an improvement of liver injury. The AhR agonist Ficz (6-formylindolo (3,2-b) carbazole) reduced liver lesions, similarly to prebiotic treatment. Conversely, inactivation of theahrgene in alcohol-fed AhRknock-outmice abrogated the beneficial effects of the prebiotic. Importantly, patients with severe alcoholic hepatitis have low levels of bacterial tryptophan derivatives that are AhR agonists.ConclusionsImprovement of alcoholic liver disease by targeting the intestinal microbiota involves the AhR pathway, which should be considered as a new therapeutic target.
Phase II study of atezolizumab in combination with bevacizumab in patients with advanced cervical cancer
Authors: Friedman Claire F , Snyder Charen Alexandra , Zhou Qin , Carducci Michael A , Buckley De Meritens Alexandre , Corr Bradley R , Fu Siqing , Hollmann Travis J , Iasonos Alexia , Konner Jason A , Konstantinopoulos Panagiotis A , Modesitt Susan C , Sharon Elad , Aghajanian Carol , Zamarin Dmitriy 
Published: October 2020

BackgroundThere are limited treatment options for patients with metastatic or recurrent cervical cancer. Platinum-based chemotherapy plus the anti-vascular endothelial growth factor antibody bevacizumab remains the mainstay of advanced treatment. Pembrolizumab is Food and Drug Agency approved for programmed death ligand 1 (PD-L1) positive cervical cancer with a modest response rate. This is the first study to report the efficacy and safety of the PD-L1 antibody atezolizumab in combination with bevacizumab in advanced cervical cancer.MethodsWe report the results from a phase II, open-label, multicenter study (NCT02921269). Patients with advanced cervical cancer were treated with bevacizumab 15 mg/kg intravenous every 3 weeks and atezolizumab 1200 mg intravenous every 3 weeks. The primary objective was to measure the objective response rate (ORR). Secondary endpoints included disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety.ResultsIn the total evaluable population (n=10), zero patients achieved an objective response as assessed by Response Evaluation Criteria In Solid Tumors (RECIST) V.1.1, resulting in a confirmed ORR of 0%. Of note, there were two patients who achieved an unconfirmed PR. The DCR by RECIST V.1.1 was 60% (0% complete response, 0% partial response, 60% stable disease). Median PFS was 2.9 months (95% CI, 1.8 to 6) and median OS was 8.9 months (95% CI, 3.4 to 21.9). Safety results were generally consistent with the known safety profile of both drugs, notably with two high-grade neurologic events.ConclusionsThe combination of bevacizumab and atezolizumab did not meet the predefined efficacy endpoint, as addition of bevacizumab to PD-L1 blockade did not appear to enhance the ORR in cervical cancer.
Ilioinguinal/Iliohypogastric versus quadratus lumborum nerve blockade for elective open inguinal herniorrhaphy: a prospective, randomized, double-blinded, equivalency trial
Authors: Edwards Christopher J , Weller Robert S , Turner James D , Dobson Sean W , Jaffe J Douglas , Reynolds J Wells , Russell Greg , Henshaw Daryl S 
Published: October 2020

Background
Open inguinal herniorrhaphy (OIH) is a commonly performed surgical procedure with expected postoperative pain. Historically, an option for regional analgesia has been an ilioinguinal and iliohypogastric nerve block (IINB). More recently, the transmuscular quadratus lumborum block (QLB) has been used as an analgesic technique for a variety of abdominal and truncal surgical procedures. Given our own institutional experiences with the performance of QLB combined with the body of literature supporting the proximal blockade of the ilioinguinal and iliohypogastric nerves via this approach, we compared the analgesia provided by an IINB to a QLB. We hypothesized that the two blocks would provide equivalent analgesia, as defined by a difference of less than±2 points on the pain scale (0–10 numeric rating scale (NRS)), for patients undergoing OIH.

Methods
Sixty patients scheduled for elective outpatient OIH under general anesthesia were randomized to preoperatively receive either an IINB or a transmuscular QLB with 0.25% bupivacaine/epinephrine/clonidine for postoperative analgesia. The primary endpoint was movement NRS pain scores at 8 hours. Secondary outcomes included resting NRS pain scores at 8 and 24 hours, movement NRS pain scores at 24 hours, incidence of opioid related side effects (nausea, vomiting, pruritus), time-to-first oral opioid analgesic, and total opioid consumption at 24 hours.

Results
Fifty-nine patients were analyzed per an intention-to-treat approach (one patient was excluded because the surgical procedure was canceled). Movement pain scores at 8 hours were equivalent (IINB 5.10±3.02 vs QLB 5.03±3.01 (mean NRS±SD); two one-sided test mean difference (90% CI), 0.07 (−1.24 to 1.38), p ≤0.01). There were no differences between groups for any of the secondary endpoints.

Conclusion
An IINB and a transmuscular QLB are equivalent with regards to their ability to provide postoperative analgesia after OIH.
Prevalence, incidence and associated risk factors of STIs during pregnancy in South Africa
Authors: Nyemba Dorothy Chiwoniso , Medina-Marino Andrew , Peters Remco P H , Klausner Jeffrey D , Ngwepe Phuti , Myer Landon , Johnson Leigh Francis , Davey Dvora Joseph 
Published: October 2020

ObjectiveSTIs during pregnancy increase adverse pregnancy and birth outcomes and may increase HIV risk. STI syndromic management is standard of care in South Africa. Our study evaluated the prevalence and incidence of STIs in pregnant women and the associated risk factors.MethodsWe combined data from two prospective observational studies of pregnant women enrolled while attending their first antenatal clinic (ANC) visit in Tshwane District and Cape Town. Women ≥18 years were tested at first ANC visit and at their first postpartum visit forChlamydia trachomatis,Neisseria gonorrhoeaeandTrichomonas vaginalisusing Xpert assays (Cepheid, USA). We evaluated the prevalence and incidence of STI and the associated risk factors using multivariable regression models.ResultsWe enrolled 669 pregnant women, 64% (n=427) from Tshwane District and 36% (n=242) from Cape Town; 80% (n=534) were women living with HIV (WLHIV) and 20% (n=135) without HIV. At enrolment, 37% (n=250) were diagnosed with at least one STI, of which 76% (n=190) were asymptomatic. STI prevalence was 40% (n=213) in WLHIV and 27% (n=37) in women without HIV (p=0.01). Baseline STI infection was associated with younger age (OR=0.95 per year, 95% CI 0.92 to 0.98), higher gestational age (adjusted OR (aOR)=1.03 per week, 95% CI 1.00 to 1.05), single relationship status (aOR=1.53, 95% CI 1.09 to 2.15) and HIV status (aOR=1.86, 95% CI 1.17 to 2.95). Of 419 participants with no STI at baseline, 21 had an incident STI during follow-up, with a mean follow-up time of 140 days. The incidence rate of STI during pregnancy and early post partum was 15 infections per 100 women-years (95% CI 9 to 23). Younger age was associated with STI incidence.ConclusionOur study shows high prevalence and incidence of STIs in pregnancy, especially in WLHIV, demonstrating the need for STI screening in ANC to prevent adverse pregnancy and birth outcomes. Most STI cases were asymptomatic and would have gone untreated with syndromic management. Aetiological STI screening is urgently needed to reduce the burden of STIs in pregnancy.
Phenomenology of scotogenic scalar dark matter
Authors: Ávila Ivania M. , De Romeri Valentina , Duarte Laura , Valle José W. F. 
Published: October 2020

AbstractWe reexamine the minimal Singlet $$+$$
+
Triplet Scotogenic Model, where dark matter is the mediator of neutrino mass generation. We assume it to be a scalar WIMP, whose stability follows from the same $${\mathbb {Z}}_{2}$$

Z
2

symmetry that leads to the radiative origin of neutrino masses. The scheme is the minimal one that allows for solar and atmospheric mass scales to be generated. We perform a full numerical analysis of the signatures expected at dark matter as well as collider experiments. We identify parameter regions where dark matter predictions agree with theoretical and experimental constraints, such as neutrino oscillations, Higgs data, dark matter relic abundance and direct detection searches. We also present forecasts for near future direct and indirect detection experiments. These will further probe the parameter space. Finally, we explore collider signatures associated with the mono-jet channel at the LHC, highlighting the existence of a viable light dark matter mass range.
Superior-Type Fast-Slow Atrioventricular Nodal Reentrant Tachycardia Phenotype Mimicking the Slow-Fast Type
Authors: Kaneko Yoshiaki , Nakajima Tadashi , Tamura Shuntaro , Hasegawa Hiroshi , Kobari Takashi , Iizuka Takashi , Kurabayashi Masahiko 
Published: October 2020

Background:
Superior-type fast-slow (sup-F/S-) atrioventricular nodal reentrant tachycardia (AVNRT) is a rare AVNRT variant using a superior slow pathway (SP) as the retrograde limb. Its intracardiac appearance, characterized by a short atrio-His (AH) interval and the earliest site of atrial activation in the His-bundle, is an initial indicator for making a diagnosis.

Methods:
Among 22 consecutive patients with sup-F/S-AVNRT, 3 (age, 68–81 years) patients had an apparent slow-fast (S/F-) AVNRT characterized by a long AH interval and the earliest site of atrial activation in or superior to the His-bundle region (tachy-long-AH).

Results:
The diagnosis of sup-F/S-AVNRT was based on the standard criteria in 2 patients and on the occurrence of Wenckebach-type atrioventricular block during tachycardia, which was attributable to a block at the lower common pathway (LCP) below the circuit of the AVNRT, detected owing to the lower common pathway potentials, in one patient. As with the typical S/F-AVNRT, tachy-long-AH was induced after a jump in the AH interval. In contrast to typical S/F-AVNRT, fluctuation in the ventriculoatrial interval was observed during the tachy-long-AH. Ventricular overdrive pacing was unable to entrain or terminate the tachy-long-AH. Moreover, the tachy-long-AH reciprocally transited to/from sup-F/S-AVNRT spontaneously or was triggered by ventricular contractions while the atrial cycle length and earliest site of atrial activation remained unchanged. Both tachycardias were cured by ablation at a single site in the right-side para-Hisian region of 2 patients and the noncoronary aortic cusp of one patient. Collectively, the essential circuit of both tachycardias was identical, and the tachy-long-AH was diagnosed as another phenotype of sup-F/S-AVNRT accompanied by sustained antegrade conduction via another bystander slow pathway breaking through the His-bundle owing to the repetitive antegrade block at the lower common pathway, thus representing a long AH interval during the ongoing sup-F/S-AVNRT.

Conclusions:
An unknown sup-F/S-AVNRT phenotype exists that apparently mimics the typical S/F-AVNRT and is also an unknown subtype of apparent S/F-AVNRT.
Detection and Quantification of Symptomatic Atherosclerotic Plaques With High-Resolution Imaging in Cryptogenic Stroke
Authors: Fakih Rami , Roa Jorge A. , Bathla Girish , Olalde Heena , Varon Alberto , Ortega-Gutierrez Santiago , Derdeyn Colin , Adams Harold P. , Hasan David M. , Leira Enrique C. , Samaniego Edgar A. 
Published: October 2020

Background and Purpose:
High-resolution vessel wall imaging (HR-VWI) is a powerful tool in diagnosing intracranial vasculopathies not detected on routine imaging. We hypothesized that 7T HR-VWI may detect the presence of atherosclerotic plaques in patients with intracranial atherosclerosis disease initially misdiagnosed as cryptogenic strokes.

Methods:
Patients diagnosed as cryptogenic stroke but suspected of having an intracranial arteriopathy by routine imaging were prospectively imaged with HR-VWI. If intracranial atherosclerotic plaques were identified, they were classified as culprit or nonculprit based on the likelihood of causing the index stroke. Plaque characteristics, such as contrast enhancement, degree of stenosis, and morphology, were analyzed. Contrast enhancement was determined objectively after normalization with the pituitary stalk. A cutoff value for plaque-to-pituitary stalk contrast enhancement ratio (CR) was determined for optimal prediction of the presence of a culprit plaque. A revised stroke cause was adjudicated based on clinical and HR-VWI findings.

Results:

A total of 344 cryptogenic strokes were analyzed, and 38 eligible patients were imaged with 7T HR-VWI. Intracranial atherosclerosis disease was adjudicated as the final stroke cause in 25 patients. A total of 153 intracranial plaques in 374 arterial segments were identified. Culprit plaques (n=36) had higher CR and had concentric morphology when compared with nonculprit plaques (
P
≤0.001). CR ≥53 had 78% sensitivity for detecting culprit plaques and a 90% negative predictive value. CR ≥53 (
P
=0.008), stenosis ≥50% (
P
<0.001), and concentric morphology (
P
=0.030) were independent predictors of culprit plaques.

Conclusions:
7T HR-VWI allows identification of underlying intracranial atherosclerosis disease in a subset of stroke patients with suspected underlying vasculopathy but otherwise classified as cryptogenic. Plaque analysis in this population demonstrated that culprit plaques had more contrast enhancement (CR ≥53), caused a higher degree of stenosis, and had a concentric morphology.
Killing behaviour of adult brood parasites
Authors: Šulc M. , Štětková G. , Jelínek V. , Czyż B. , Dyrcz A. , Karpińska O. , Kamionka-Kanclerska K. , Rowiński P. , Maziarz M. , Gruszczyński A. , Hughes A.E. , Honza M. 
Published: October 2020

Abstract
Decades of studies have revealed the striking adaptations of avian brood parasites for their unique reproductive lifestyle. Several have reported that adult brood parasites sometimes kill host nestlings, although the reasons for this behaviour remain unclear. Using continuous video-recording and camera traps, we observed the same behaviour in the common cuckoo Cuculus canorus, showing that both host and parasite nestlings can be killed. The latter has never previously been observed in cuckoos. Here, we review this phenomenon and discuss possible explanations.
Predators learning to avoid toxic invasive prey: a study on individual variation among free-ranging lizards
Authors: Ward-Fear Georgia , Brown Gregory P. , Shine Richard 
Published: October 2020

Abstract
Within all wild populations, individuals vary in ways that affect their vulnerability to threatening processes. Understanding that variation may clarify mechanisms of population persistence and/or evolution. In Australia, Yellow-spotted Monitors (Varanus panoptes), decline by >90% when toxic Cane Toads (Rhinella marina) invade an area. Taste-aversion training (exposing animals to non-lethal toads) can buffer impacts; but does pre-existing behavioural variation also influence survival? An individual’s fate can be predicted from its behaviour during aversion-training trials. Lizards presented with small toads either consumed them, rejected them, or fled. When Cane Toads invaded our study site, mortality was lower in lizards that ‘consumed’ (aversion-trained) than in those that ‘fled’ (untrained), but even lower in lizards that ‘rejected’ toads outright. Thus, animals reluctant to consume toads in trials survived despite never being aversion-trained. In this system, lizard vulnerability is driven by boldness, behavioural responses to novel prey types, and the opportunity to learn aversion.
Comparing the efficiency of six common methods for DNA extraction from root-lesion nematodes (Pratylenchus spp.)
Authors: Orlando Valeria , Edwards Simon G. , Neilson Roy , Prior Tom , Roberts David , Back Matthew 
Published: October 2020

Summary
Robust and accurate identification of root-lesion nematodes (Pratylenchus spp.) is an essential step for determining their potential threat to crop yields and, consequently, development of an efficient agronomic management strategy. It is recognised that DNA-based techniques provide rapid identification of a range of plant-parasitic nematodes including Pratylenchus spp. Efficient and repeatable DNA extraction is central to molecular methodologies. Here, six common DNA extraction protocols were compared to evaluate their efficiency to obtain quality DNA samples for Pratylenchus penetrans. Samples with five and ten individuals of P. penetrans were successfully extracted and amplified by all extraction methods tested, whereas samples with a single nematode presented challenges for DNA amplification. Among all methods tested, the DNA extraction protocol with glass beads proved to be efficient for P. penetrans and all other species tested (P. crenatus, P. neglectus and P. thornei), generating high quality DNA at comparatively low cost and with a rapid sample throughput.
Assaulting Sophia, Protecting Sophia: the Female Body as a Symbolic Artifact in Gnostic Mythology
Authors: Dawson Cindy 
Published: October 2020

Abstract
This article explores the construction and function of the female body in four Gnostic texts: Pistis Sophia, On the Origin of the World, Hypostasis of the Archons, and Apocryphon of John. In these texts’ accounts of the mythological origin of the cosmos, the exposed bodies of Sophia and her daughters are consistently depicted as objects of excessive, often gratuitous sexual violence. Yet in the midst of this violence appears another, equally consistent motif: the Gnostic writers protected their female characters through a variety of narratival techniques, such as transforming the female body into a tree or a strenuous insistence on the violence’s ultimate failure. This article accounts for this curious pairing of violence and protection by evaluating the female body as a symbolic artifact embedded with the values of the patriarchal culture which constructed it, a culture which valued the female body as a reliable, untainted conduit of progeny.
Eric Voegelin and Gnostic Hollywood: Cinematic Portrayals of the Immanentization of the Eschaton in Dark City (1998) and Pleasantville (1998)
Authors: Kwiatkowski Fryderyk 
Published: October 2020

Abstract
In the first part of the paper, I will provide an overview of Eric Voegelin’s early thesis about Gnosis which he formulated in The New Science of Politics (1952) and Science, Politics, and Gnosticism (1968). A special attention will be paid to the idea of the immanentization of the eschaton which remains in the center of his argument. In the second part of the paper, I will analyze two Hollywood films in the light of Voegelin’s thesis: Dark City (1998) and Pleasantville (1998). Firstly, I will argue that the main characters depicted in the films can be classified as Gnostics in Voegelin’s sense. Secondly, I will demonstrate that their revolutionary acts reflect the idea of the immanentization of the eschaton.
Preparation of the Japanese Version of the Diabetes Caregiver Activity and Support Scale and Verification of Its Reliability and Validity
Authors: Ida Satoshi , Kaneko Ryutaro , Imataka Kanako , Okubo Kaoru , Shirakura Yoshitaka , Azuma Kentaro , Fujiwara Ryoko , Takahashi Hiroka , Scarton Lisa J. , Murata Kazuya 
Published: October 2020

Purpose The purpose of the study was to adapt and psychometrically evaluate a Japanese language version of the Diabetes Caregiver Activity and Support Scale (D-CASS-J) to be culturally relevant for people with diabetes living in Japan. Methods A Japanese translation of the original version of the D-CASS was prepared, corrected, and back-translated. Family caregivers of patients with diabetes mellitus ages ≥65 years who visited the outpatient diabetes clinic of Ise Red Cross Hospital were included. Cronbach’s α coefficients were calculated as an assessment of internal consistency. Exploratory factor analyses were performed to verify construct validity. Hierarchical multiple regression analyses were performed using depression as the dependent variable and D-CASS-J and other variables as explanatory variables. Pearson’s correlation coefficients between D-CASS-J scores and the support burden scale scores were calculated to verify criterion-related validity. Results This analysis included 268 subjects. Cronbach’s α coefficient was .86. Factor analyses showed the same single-factor structure as the original version of the D-CASS. Hierarchical multiple regression analyses based on the conceptual model demonstrated construct validity. D-CASS-J scores were significantly correlated with support burden scale scores. Conclusions For family caregivers of elderly patients with diabetes in Japan, D-CASS-J can be used as a tool to evaluate difficulties experienced while providing support to patients.