bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons Learned from the Early Stage of Convid-19 Pandemic: Clinical Analysis of 17 Related Deaths Associated with the 2019 Novel Coronavirus
Authors: Zhang Cheng , Hong Dandan , Chen Wenyue , Guan Qun , Ren Qingling 
Published: June 2020

Abstract
Background Since the end of December 2019, a pneumonia outbreak has occurred in Wuhan, Hubei Province, China. An epidemiological survey showed that the pneumovirus infection was closely related to the Huanan Seafood Wholesale Market in Wuhan, causing great panic among the general population. Through isolation of the pneumovirus strain and whole-genome sequencing, an infection model of the pneumovirus in human airway epithelial cells was established, and the pneumovirus was identified as the 2019 novel coronavirus (2019-nCoV), which belongs to the β-coronavirus genus. This study focused on the different characteristics of 2019-nCoV, which we learned at the early stage of Covid-19 pandemic will help us to save more lives during the outbreak. Methods The data of 17 deaths from 13 hospitals in Wuhan were obtained, and the initial symptoms, clinical features during the progression of the disease, and treatment processes were well analyzed. Results At the initial phase of the outbreak of 2019-nCoV, the lack of effective drugs for pneumonia has led to lethal results in people who are often elderly with multiple underlying conditions. Males were affected more than females. Fever, dry coughing, shortness of breath were the primary presentations, but not all. Chest images showed typical features of viral pneumonia. Respiratory support treatment were needed, although sometimes did not improve respiratory distress. All the patients died of multiple organ failure caused by respiratory failure. Many treatments of covid-19 were done in ICU and lasted for a long time, the occupation of public medical resources will put pressure on the present medical system.Conclusions COVID-19 is different from pneumonia caused by previous coronaviruses, it is more infectious and hard to manage. The initial death population were mainly elderly patients with underlying diseases. Protecting the elderly is an effective method to reduce the number of deaths. In the absence of nucleic acid detection reagents, relying on identifying typical symptoms and making full use of CT can increase the diagnosis of suspicious people. The condition of patients may deteriorate rapidly which increased the complexity of treatment. The increasing number of patients will put great pressure on the existing medical system.
Colitis Cystica Profunda with Gastrointestinal Stromal Tumor: A Case Report
Authors: Ren Xiaolu , Jiang Bo , Zhang Yixun 
Published: June 2020

Abstract
Backgroud: Colitis Cystica Profunda(CCP) is a rare benign medical condition and its exact etiology is still unknown. The clinical symptoms could be atypical and even asymptomatic, and also associated with several diseases. Most CCP patients may be misdiagnosed due to its complexity, and can be recognized after long-term medical treatment or surgical resection, especially in the elder or patients with relevant family history. Case presentation: In this case, a 58-year-old man presented with change in bowel habits for 3 years. Gastroscopy and colonoscopy were performed, and the lesions in stomach were resected. Colonoscopy revealed most lesions were significantly smaller after the resection of stomach neoplasm. Notably, these lesions recurred 3 years later. Conclusion: This case is an important reference for primary physician and pathologist to make correct diagnosis through initial endoscopic and pathological examination.
Association of diurnal temperature range with daily hospitalization for exacerbation of chronic respiratory diseases in 21 cities, China
Authors: Wang Zihui , Zhou Yumin , Luo Ming , Yang Huajing , Xiao Shan , Huang Xiaoliang , Ou Yubo , Zhang Yongbo , Duan Xianzhong , Hu Wei , Liao Chenghao , Zheng Yijia , Wang Long , Xie Min , Tang Longhui , Zheng Jinzhen , Liu Sha , Wu Fan , Deng Zhishan , Tian Heshen , Peng Jieqi , Wang Xinwang , Zhong Nanshan , Ran Pixin 
Published: June 2020

Abstract
Background
The association between diurnal temperature range (DTR) and hospitalization for exacerbation of chronic respiratory diseases (CRD) was rarely reported.
Objectives
To examine the association between DTR and daily hospital admission for exacerbations of CRD and find out the potential effect of modifications on this association.
Method:
Data on daily hospitalization for exacerbation of chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis and meteorology measures from 2013 through 2017 were obtained from 21 cities in South China. After controlling the effects of daily mean temperature, relative humidity (RH), particulate matter < 2.5 µm diameter (PM2.5) and other confounding factors, a standard generalized additive model (GAM) with a quasi-Poisson distribution was performed to evaluate the relationships between DTR and daily hospital admissions of CRD in a two-stage strategy. Subgroup analysis was performed to find potential modifications, including seasonality and population characteristics.
Result
Elevated risk of hospitalization for exacerbation of CRD (RR = 1.09 [95%CI: 1.08 to 1.11]) was associated with interquartile range (IQR) increase in DTR. The effects of DTR on hospital admissions for CRD were strong at low DTR in the hot season and high DTR in the cold season. The relative risk (RR) of hospitalization was 1.11 (95%CI: 1.08 to 1.12) for exacerbations of COPD and 1.09 (95%CI: 1.05 to 1.13) for asthma per IQR increase in DTR. The adverse effect of DTR on hospitalization for bronchiectasis was only observed in female patients (RR = 1.06 [95%CI: 1.03 to 1.10]).
Conclusion
Our study provided additional evidences for the association between DTR and daily hospitalization for exacerbation of CRD, especially in COPD patients and the cold season.
Bioconversion of Biphenyl to A Polyhydroxyalkanoate Copolymer by Alcaligenes Denitrificans A41
Authors: Yajima Taito , Nagatomo Mizuki , Wakabayashi Aiko , Sato Michio , Taguchi Seiichi , Maeda Michihisa 
Published: June 2020

Abstract
A polyhydroxyalkanoate (PHA) copolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)], was biosynthesized from biphenyl as the sole carbon source using Alcaligenes (currently Achromobacter) denitrificans A41. This strain is capable of degrading polychlorinated biphenyls (PCBs) and biphenyl. This proof-of-concept of the conversion of aromatic chemicals such as the environmental pollutant PCBs/biphenyl to eco-friendly products such as biodegradable polyester PHA was inspired by the uncovering of two genes encoding PHA synthases in the A. denitrificans A41 genome. When the carbon/nitrogen (C/N) ratio was set at 21, the cellular P(3HB-co-3HV) content in strain A41 reached its highest value of 10.1%. A two-step cultivation protocol improved the accumulation of P(3HB-co-3HV) by up to 26.2% of the dry cell weight, consisting of 13.0 mol% 3HV when grown on minimum salt medium without nitrogen sources. The highest cellular content (47.6%) was obtained through the two-step cultivation of strain A41 on biphenyl as the sole carbon source. The purified copolymer had ultra-high molecular weight (weight-average molecular weight of 3.5 × 106), as revealed through gel-permeation chromatography. Based on the genomic information related to both polymer synthesis and biphenyl degradation, we finally proposed a metabolic pathway for the production of P(3HB-co-3HV) associated with the degradation of biphenyl by strain A41. This is, as it were, a metabolic link between PHA synthesis and biphenyl degradation.
Seasonal Changes in Incidence of Patients With Diabetes Undergoing Cardiac Surgery
Authors: Kovacs Barbara N , Petak Ferenc , Agocs Szilvia , Virag Katalin , Nyari Tibor , Molnar Andrea , Sudy Roberta , Lengyel Csaba , Babik Barna 
Published: June 2020

Abstract
Background: To evaluate the monthly incidence rate of patients with diabetes requiring heart surgery at a tertiary-care university hospital in East-Central Europe with a temperate climate zone. We also assessed whether additional factors affecting small blood vessels (smoking, aging, and diabetes) modulate the seasonal variability of diabetes.Methods: Medical records were retrospectively analyzed for all 9837 consecutive adult patients who underwent surgery at our institution between 2007 and 2018. Individual seasonal variations of diabetes, smoking, and elderly patients were analyzed monthly. Potential additive or subtractive effects of the coexistence of these factors in seasonal changes in incidence rates were also examined. In the absence of a waiting list, incidence rates accurately reflect the frequency of exacerbation of cardiovascular symptoms requiring surgical intervention.Results: Significant seasonal variations in the monthly incidence rate of diabetes (p < 0.02), smoking (p < 0.001), and elderly (p < 0.001) patients were observed at the cardiac surgery unit. The peak incidence of non-elderly and smoking patients with diabetes was during winter, whereas heart surgery in elderly patients without diabetes and smoking was most frequently required in summer. Concomitant occurrence of diabetes and smoking had an additive effect on the relative incidence rate of requirement for cardiac surgery (p < 0.001), while the simultaneous presence of older age and diabetes or smoking eliminated seasonal variations.Conclusions: Scheduling regular cardiovascular control in accordance with periodicities in diabetes, elderly, and smoking patients more than once a year may improve patient health and social consequences.Trial registration: NCT03967639
Tyrosine kinase inhibitors–induced hypothyroidism as a prognostic factor in metastatic renal cell carcinoma: a systematic review and meta-analysis
Authors: Bo Li , Zhou Liang , Tang Yin , Liu Yu , Li Hong , Wang Kunjie 
Published: June 2020

Abstract
Background

Hypothyroidism as a predictive factor represent highly controversial in patients with metastatic renal cell carcinoma (mRCC) with tyrosine kinase inhibitors-induced (TKI-induced) hypothyroidism. we aimed to evaluate the predictive value of TKI-induced hypothyroidism for progression-free survival (PFS) in patients with mRCC.
Methods

PubMed, Web of Science and Cochrane Library databases were searched with the keywords of "renal cell carcinoma", "hypothyroidism", "tyrosine kinase inhibitor", "sunitinib", "axitinib", "sorafenib" and "pazopanib" until September 2019. The hazard ratio (HR) and 95% confidence interval (CI) of extracted from progression-free survival (PFS) were statistically analyzed by STATA15.1 software. Heterogeneity was assessed by I²value. Publication bias was appraised by the funnel chart, Egger's and Begg's tests.
Results

Eighteen studies with more than 1300 patients were included in this meta-analysis. The result demonstrated that TKI-induced hypothyroidism was an effective predictor of longer PFS (HR = 0.57,95%CI:0.49–0.66, P༜0.001, I²=34.4%) in patients with mRCC. No significant publication bias was detected.
Conclusions

Our analysis harvested from currently available clinical evidence shows that TKI-induced hypothyroidism expressed longer PFS, compared with euthyroidism, among patients with mRCC treated with "sunitinib", "axitinib", "sorafenib" and "pazopanib".
Effect of meteorological factors on the activity of influenza in Chongqing, China, 2012–2019
Authors: Qi Li , Liu Tian , Gao Yuan , Tian Dechao , Li Qin , Su Kun , Tang Wenge , Feng Luzhao , Liu Qiyong 
Published: June 2020

Abstract
Background

The effects of multiple meteorological factors on influenza activity remain elusive in Chongqing, the largest municipality in China. We aimed to fix this gap in this study.
Methods

Weekly meteorological data and influenza surveillance data in Chongqing were collected from 2012 to 2019. Distributed lag nonlinear models (DLNMs) were conducted to estimate the effects of multiple meteorological factors on influenza activity.
Results

Inverted J-shaped nonlinear associations between mean temperature, wind speed, sunshine and influenza activity were found. The relative risks (RRs) of influenza activity increased as weekly average mean temperature fell below 18.18℃, average wind speed fell below 1.55 m/s and average sunshine fell below 2.36 hours. Taking the median values as the references, lower temperature and windless could significantly increase the risks of influenza activity and last for 4 weeks. A J-shaped nonlinear association was observed between relative humidity and influenza activity; the risk of influenza activity increased with rising relative humidity with 78.26% as the break point. Taking the median value as the reference, high relative humidity could increase the risk of influenza activity and last for 3 weeks. In addition, we found the relationship between aggregate rainfall and influenza activity could be described with a U-shaped curve. The RR for rainfall effect was significantly higher than rainless effect.
Conclusions

Our study shows that multiple meteorological factors have strong associations with influenza activity in Chongqing, providing evidence for developing a meteorology-based early warning system for influenza to facilitate timely response to upsurge of influenza activity.
Correlation Study Between Minerals Composition and Porosity Evolution of Black Shale Under Different Oxidation Mechanisms
Authors: Zhu Baolong , Li Jing , Li Qi 
Published: June 2020

Abstract
The correlation between rock minerals composition and porosity evolution is essential to black shale oxidation,chemical and biological effects may act different roles which is unclear. In present study, the acid solution and Acidithiobacillus ferrooxidans was applied to simulate the chemical and biological effects, the total organic carbon (TOC), pyrite and clay minerals content, porosity characteristics, micro-surfacemorphologyof black shale sampleswere employed to analyze the minerals-porosity correlation. Results showed that the chemical effect led to a greaterdecrease of pyrite and increase of clay minerals content than biological effect, which accompanied by a higherspecific surface areas and pore volume. These difference may attribute to the TOCcontent, which decreasedby acid erosion and led to the increase of macropores in chemical group, then promoted the minerals reactions; whereas the TOC content increased byattached and dead bacteria cell bodies on rock surface, led to the increase of micropores and less minerals reactions in biological group. It suggests that the correlation between minerals composition and porosity evolution is different in chemical and biological effects, is mainly due to the different alter trends of TOC content.
Evaluating survey designs for targeting preventive chemotherapy against Schistosoma haematobium and Schistosoma mansoni across Sub-Saharan Africa: a geostatistical analysis and modelling study
Authors: Fornace Kimberly , Fronterrè Claudio , Fleming Fiona M , Simpson Hope , Zoure Honorat , Rebollo Maria , Mwinzi Pauline , Pullan Rachel L 
Published: June 2020

Abstract
Background
Schistosomiasis control programmes primarily use school-based surveys to identify areas for mass drug administration of preventive chemotherapy. However, as the spatial distribution of schistosomiasis can be highly focal, transmission may not be detected by surveys implemented at districts or larger spatial units. Improved mapping strategies are required to accurately and cost effectively target preventive chemotherapy to remaining foci across all possible spatial distributions of schistosomiasis.
Methods
Here, we use geostatistical models to quantify the spatial heterogeneity of Schistosoma haematobium and S. mansoni across Sub-Saharan Africa using the most comprehensive dataset available on school-based surveys. Applying this information to parameterise simulations, we assess the accuracy and cost of targeting alternative implementation unit sizes across the range of plausible schistosomiasis distributions. We evaluate the consequences of decisions based on survey designs implemented at district and subdistrict levels sampling different numbers of schools. Cost data was obtained from field surveys conducted across multiple countries and years, with cost effectiveness evaluated as the cost per correctly identified school.
Results
Models identified marked differences in prevalence and spatial distributions between countries and species; however, results suggest implementing surveys at subdistrict level increase the accuracy of treatment classifications across most scenarios. While intensively at subdistrict level resulted in the highest classification accuracy, this sampling strategy resulted in the highest costs. Alternatively, sampling the same numbers of schools currently recommended at district levels but stratifying by subdistrict increased cost effectiveness.
Conclusions
This provides a new tool to evaluate schistosomiasis survey designs across a range of transmission settings. Results highlight the importance of considering spatial structure when designing sampling strategies, illustrating that a substantial proportion of children may be undertreated even when an implementation unit is correctly classified. Control programmes need to weigh the increased accuracy of more detailed mapping strategies against the survey costs and treatment priorities.
Microorganisms and Clinical Outcomes of Early- and Late-onset Ventilator-associated Pneumonia at Srinagarind Hospital, a Tertiary Center in Northeastern Thailand
Authors: Arayasukawat Pavarit , So-ngern Apichart - , Reechaipichitkul Wipa , Chumpangern Worawat , Arunsurat Itthiphat , Ratanawatkul Pailin , Chuennok Wanna 
Published: June 2020

Abstract
Back ground: Ventilator-associated pneumonia (VAP) isacommon nocosomial infection inintensive care unit (ICU). Local microbiological surveillance of pathogens and resistance patternsfor early-onset VAP (EOVAP) and late-onset VAP (LOVAP)will help to choose appropriate empiric antibiotics.Objective: To comparethe multi-drug resistant (MDR) pathogens, treatment outcomes,and factors associated with hospital mortality of VAP. Method:A cross-sectional studybetween 1 January 2015 and 31 December 2017 at Srinagarind hospital, KhonKaen University was conducted. The demographic data, causative pathogens, hospital length of stay (LOS), ICU LOS, mechanical ventilator (MV) days, and hospital mortality were retrospectively reviewed.Results:One hundred and ninety patients were enrolled; 42 (22%) were EOVAP and 148 (78%) were LOVAP. Acinetobacterbaummanii was the most common pathogen in both groups (50 % EOVAP vs 52.7% LOVAP). MDR pathogens were significant greater in LOVAP (81.8 %) than EOVAP (61.9%) (p = 0.007). The EOVAP had a significantly better ICU LOS (median 20.0 (11.0, 30.0) vs. 26.5 (17.0, 43.0) days), hospital LOS (median 26.5 (15.0, 44.0) vs. 35.5 (24.0, 56.0) days) shorter MV days (14.0 (10.0, 29.0) vs. 23.0 (14.0, 35.5) days) and lowerhospital mortality (11.9 % VS 27.7%) than LOVAP ( p< 0.05). The factor associated with hospital mortality washavingsimplified acute physiology score (SAP)≥ 40 with an adjustedodds ratio(aOR) of 2.22 (95%CI, 1.08-4.54,p = 0.02). Conclusion: LOVAP had significantly higherMDR pathogens, MV days, ICU LOS, hospital LOS andhospital mortality than EOVAP. A broad-spectrum antibiotic to cover MDR pathogensshould be considered in LOVAP.The factor associated with hospital mortality of VAP was a SAPII score ≥ 40.
Robot-Assisted Radical Prostatectomy: A Survey on the Influence of Postoperative Results Analysis and Surgical Video Review on Postoperative Complications and Functional Results.
Authors: Beulens Alexander J.W. , Veerman Hans , Brinkman Willem , Koldewijn Evert , Hendrikx Ad , Basten Jean Paul van , Merrienboer Jeroen van , Bangma Chris , Wagner Cordula , Poel Henk van der 
Published: June 2020

Abstract
Background: Effective training and assessment of performance are fundamental to ensuring that surgeons reach their intended goal and operate safely with maximum preservation of functions. The field of video review and postoperative results analysis is focused on predicting postoperative results and reducing complications. Even though multiple groups have investigated the possibility of video review it is unclear if video review has found its place in daily clinical practice. To investigate the experiences and opinions of surgeons in the field of Robot-assisted Radical Prostatectomy (RARP) on the influence of video reviews and postoperative results analysis on postoperative complications and functional results.Design, Setting, and Participants: RARP surgeons who were expected to perform video reviews and postoperative results analysis were identified. A total of 93 RARP surgeons were invited to participate in this survey. Online questionnaires were distributed. The questionnaire contained the following domains: background information of the RARP surgeons, evaluation of the use of postoperative results analysis and surgical video review, and future recommendations.Results: A total of 30 RARP surgeons responded to the questionnaire. 27 respondents organized periodical results analyses, 17 of them reviewed edited videos as part of standard clinical practice in their hospital. Most respondents recommend video review, and are convinced it improves outcomes through self-reflection, feedback from a colleague, or from seeing different techniques and ‘tricks’. Conclusion: RARP surgeons have accepted the implementation of postoperative results analysis and surgical video review as forms of quality assurance and self-reflection. They use edited surgical videos to gain insight into the specific facets of RARP related to postoperative complications and functional outcomes.
Two infants with COVID-19 acquired from infected mothers: The incompatibility of maternal intensity and infant lung involvement: A case report
Authors: Moeindarbary Somayeh , Pourhoseini Seyedeh Azam , Layegh Parvaneh , Shahriari Zahra , Fayyaz Faezeh , Bahrami Milad , Rafiee Mahdi 
Published: June 2020

Abstract
IntroductionThe outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency by world health organization (WHO) on 30 January 2020. Recent studies have suggested that infants present the symptoms of COVID-19. Although the presentation of the disease in babies is variable, there are limited studies about the infected babies with 2019-nCoV.Case presentationIn this study, we have presented a case report of two infants with COVID-19. According to the simultaneity of maternal infection, maternal-fetal transmission or postnatal transmission was suggested. The chest radiography of one of the neonates suggested severe lung involvement. Despite the supportive and resuscitation attempts, poor clinical condition of him led to his death. Fortunately, the two mothers and one of the babies were discharged from the hospital with a good general condition.ConclusionIn this paper, we have reported two infants who had positive results of COVID-19 testing at day one of life. The babies had worse clinical conditions than their mothers and the intensity of pneumonia and the level of lung involvement of the infants were not associated with the stage and disease severity of the mothers who infected with 2019-nCoV.