bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Printing Using Cellulose Nanocrystals Reinforced GelMA/HAMA Hydrogels for Improved Structural Integration
Authors: Fan Yuchao , Yue Zhilian , Lucarelli Enrico , Wallace Gordon G. 
Published: November 2020

Abstract3D printing of soft‐tissue like cytocompatible single material constructs with appropriate mechanical properties remains a challenge. Hybrid printing technology provides an attractive alternative as it combines a cell‐free ink for providing mechanical support with a bioink for housing embedded cells. Several hybrid printed structures have been developed, utilizing thermoplastic polymers such as polycaprolactone as structural support. These thermoplastics demonstrated limited structural integration with the cell‐laden components, and this may compromise the overall performance. In this work, a hybrid printing platform is presented using two distinct hydrogel inks that share the same photo‐crosslinking chemistry to enable simple fabrication and seamless structural integration. A mechanically reinforced hydrogel ink is developed comprising cellulose nanocrystals and gelatin methacryloyl/hyaluronic acid methacrylate (GelMA/HAMA) as the structural component, and GelMA/HAMA as the cytogel containing a mouse chondrogenic cell line, ATDC5. Hybrid printed constructs with encapsulated cells are fabricated using the two optimized inks, and the structural integration of the constructs is evaluated by cyclic mechanical compression. Finally, the cell viability of encapsulated ATDC5 cells in the hybrid printed structures is evaluated.
Antimonene Nanosheets‐Based Z‐Scheme Heterostructure with Enhanced Reactive Oxygen Species Generation and Photothermal Conversion Efficiency for Photonic Therapy of Cancer
Authors: Kang Yong , Li Zhengjun , Yang Yanli , Su Zhiguo , Ji Xiaoyuan , Zhang Songping 
Published: November 2020

AbstractA Z‐scheme heterojunction with high separation efficiency of photogenerated electrons and holes and enhanced reduction/oxidation potentials, which can enhance reactive oxygen species generation and photothermal conversion efficiency, exhibits tremendous potential in photonic theranostics. Herein, antimonene nanosheets (Sb NSs) are functionalized with photosensitizer 5,10,15,20‐Tetrakis(4‐hydroxy‐phenyl)‐21H,12H‐porphine (THPP) and a poly(ethylene glycol) (PEG) modifier. The Sb–THPP–PEG NSs thus fabricated are found to form a Z‐scheme heterojunction structure between Sb and THPP, based on their valence band and bandgap level analysis. The Z‐scheme heterojunction structure enables the Sb–THPP–PEG NSs multiple promising features for cancer therapy. Firstly, due to improved electron–hole pairs separation efficiency and redox potential, new reactive oxygen species •O2− is generated, besides the production of 1O2 by THPP. Secondly, the assembly of THPP enhances the NIR‐light‐to‐heat conversion of Sb NS, a photothermal conversion efficiency as high as 44.6% is obtained by this Sb–THPP–PEG NSs photonic nanomedicine. Moreover, the photothermal, fluorescent, and photoacoustic imaging properties of Sb–THPP–PEG NSs allow multimodal imaging‐guided tumor treatment.
Controlling Light, Heat, and Vibrations in Plasmonics and Phononics
Authors: Cunha Joao , Guo Tian‐Long , Della Valle Giuseppe , Koya Alemayehu Nana , Proietti Zaccaria Remo , Alabastri Alessandro 
Published: November 2020

AbstractPlasmonic nanostructures have attracted considerable attention for their ability to couple with light and provide strong electromagnetic energy confinement at subwavelength dimensions. The absorbed portion of the captured electromagnetic energy can lead to significant heating of both the nanostructure and its surroundings, resulting in a rich set of nanoscale thermal processes that defines the subfield of thermoplasmonics with applications ranging from nanochemistry and nanobiology to optoelectronics. Recently, phononic nanostructures have started to attract attention as a platform for manipulation of phonons, enabling control over heat propagation and/or mechanical vibrations. The complex interaction phenomena between photons, electrons, and phonons require appropriate modelling strategies to design nanodevices that simultaneously explore and exploit the optical, thermal, and mechanical degrees of freedom. Examples of such devices are micro‐ and nanoscale opto‐thermo‐mechanical systems for sensing, imaging, energy conversion, and harvesting applications. Here, an overview of the fundamental theory and concepts crucial to the modelling of plasmo‐phonon devices is provided. Particular attention is given to micro‐ and nanoscale modelling frameworks, highlighting their validity ranges and the experimental works that contributed to their validation and led to compelling applications. Finally, an open‐ended outlook focused on emerging applications at the intersection between plasmonics and phononics is presented.
Achieving Ultrahigh Output Energy Density of Triboelectric Nanogenerators in High‐Pressure Gas Environment
Authors: Fu Jingjing , Xu Guoqiang , Li Changheng , Xia Xin , Guan Dong , Li Jian , Huang Zhengyong , Zi Yunlong 
Published: November 2020

AbstractThrough years of development, the triboelectric nanogenerator (TENG) has been demonstrated as a burgeoning efficient energy harvester. Plenty of efforts have been devoted to further improving the electric output performance through material/surface optimization, ion implantation or the external electric circuit. However, all these methods cannot break through the fundamental limitation brought by the inevitable electrical breakdown effect, and thus the output energy density is restricted. Here, a method for enhancing the threshold output energy density of TENGs is proposed by suppressing the breakdown effects in the high‐pressure gas environment. With that, the output energy density of the contact‐separation mode TENG can be increased by over 25 times in 10 atm than that in the atmosphere, and that of the freestanding sliding TENG can also achieve over 5 times increase in 6 atm. This research demonstrates the excellent suppression effect of the electric breakdown brought by the high‐pressure gas environment, which may provide a practical and effective technological route to promote the output performance of TENGs.
Insight into Prolonged Cycling Life of 4 V All‐Solid‐State Polymer Batteries by a High‐Voltage Stable Binder
Authors: Liang Jianneng , Chen Dachang , Adair Keegan , Sun Qian , Holmes Nathaniel Graham , Zhao Yang , Sun Yipeng , Luo Jing , Li Ruying , Zhang Li , Zhao Shangqian , Lu Shigang , Huang Huan , Zhang Xiaoxing , Singh Chandra Veer , Sun Xueliang 
Published: November 2020

AbstractPolyethylene oxide (PEO) based solid polymer electrolytes (SPEs) are incompatible with the 4 V class cathodes such as LiCoO2 due to the limited electrochemical oxidation window of PEO. Herein, a number of binders including commonly used binders PEO, polyvinylidene fluoride (PVDF), and carboxyl‐rich polymer (CRP) binders such as sodium alginate (Na‐alginate) and sodium carboxymethyl cellulose, are studied for application in the 4 V class all‐solid‐state polymer batteries (ASSPBs). The results show ASSPBs with CRP binders exhibit superior cycling performance up to 1000 cycles (60% capacity retention, almost 10 times higher than those with PEO and PVDF binders). Synchrotron‐based X‐ray absorption spectroscopy (XAS), morphology studies and density functional theory studies indicate that, with their carboxyl groups, CRPs can strongly bind the electrode materials together, and work as coating materials to protect the cathode/SPE interface. Cyclic voltammetry studies indicate that CRP binders are more stable at high voltage compared to PEO and PVDF. The stability under high voltage and the coating property of CRP binders contribute to stable cathode/SPE interfaces as disclosed by the X‐ray photoelectron spectroscopy and Co L‐edge XAS results, enabling long cycling life, high performance 4 V class ASSPBs.
Improved Asparaginyl‐Ligase‐Catalyzed Transpeptidation via Selective Nucleophile Quenching
Authors: Rehm Fabian B. H. , Tyler Tristan J. , Yap Kuok , Durek Thomas , Craik David J. 
Published: November 2020

AbstractThe use of enzymes for the site‐specific modification of proteins/peptides has become a highly accessible, widespread approach to study protein/peptide functions or to generate therapeutic conjugates. Asparaginyl endopeptidases (AEPs) that preferentially catalyze transpeptidation reactions (AEP ligases) have emerged as enticing alternatives to established approaches, such as bacterial sortases, due to their catalytic efficiency and short tripeptide recognition motifs. However, under standard conditions, a substantial excess of the nucleophile to be conjugated is needed to reach desirable yields. Herein we report a versatile approach to shift the AEP‐catalyzed transpeptidation equilibrium toward product formation via selectively quenching the nucleophilicity of the competing leaving‐group peptide. Our metal‐complexation‐based strategy enables efficient peptide/protein labeling at the N‐ or C‐terminus with near‐equimolar concentrations of nucleophile label. Furthermore, we show that this approach can enhance protein–protein ligation and facilitate the formation of transpeptidation products that are otherwise unattainable.
Surveys of recreational anglers reveal knowledge gaps and positive attitudes towards manta ray conservation in Florida
Authors: Pate Jessica H. , Macdonald Catherine , Wester Julia 
Published: November 2020

Abstract

South Florida has a significant number of recreational anglers, and some shore‐based fishing sites overlap with habitat for juvenile manta rays. Although manta rays are prohibited from harvest in Florida, they are frequently seen foul‐hooked or entangled in fishing line.
Recreational anglers (n = 198) were surveyed at piers and inlet jetties in Palm Beach County, Florida, USA to assess their knowledge of and actions and attitudes towards manta rays.
Analysis of the responses revealed that while most anglers could identify a manta ray (66.7%) and expressed no interest in casting at (93.4%) or catching a manta ray (95.5%), they lacked knowledge about threats to mantas, as well as their conservation and protected status. Surveyed anglers overwhelmingly supported manta ray conservation (82.3%) and environmental protection (98.0%).
Results indicate pier and inlet anglers are not using tackle strong enough to land a large ray to remove fishing gear, therefore it is recommended that outreach focuses on preventing recreational fishery interactions with manta rays, encouraging use of environmentally friendly tackle, and fostering engagement with anglers as citizen scientists.
These results can inform the design of outreach materials aimed at closing knowledge gaps and encouraging best practices. Positive attitudes towards the environment and existing neutral behaviours towards manta rays indicate an opportunity to shift the behaviour of shore‐based anglers in this area in support of manta ray conservation.
The dark figure of sexual offending: A replication and extension
Authors: Drury Alan J. , Elbert Michael J. , DeLisi Matt 
Published: November 2020

AbstractStudies of the dark figure of sexual offending using federal correctional clients reported significant evidence of previously unknown or hidden sexual violence, often among clients with no official criminal history. Unfortunately, research has produced variable estimates of how large the dark figure is. The current study sought to replicate recent studies of federal sexual offenders about the dark figure of sexual offending. We also extended the knowledge base by providing additional correlational analyses to see whether self‐reported and official sexual offending have shared or divergent correlates. Overall, 73.8% of federal sexual offenders reported prior contact victims, which is higher than, but generally consistent with, prior prevalence estimates of 55–69% in studies of federal correctional clients. In the current data, clients convicted of child pornography possession or receipt and who had no official record of sexual abuse nevertheless reported contact sexual offenses in more than 59% of cases.
The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis
Authors: Chen Yanglan , Cong Rong , Ji Chengjian , Ruan Wenhua 
Published: November 2020

AbstractBackgroundThe prognostic role of the C‐reactive protein (CRP) in head and neck squamous cell carcinoma (HNSCC) has not been well investigated. This meta‐analysis aimed to evaluate the prognostic relevance of elevated CRP levels in patients with HNSCC.MethodsA relevant literature search was performed in PubMed, Web of Science, and Embase up to September 1, 2020. The pooled odds ratio and hazard ratio (HR) with 95% confidence interval (CI) were applied to evaluate the difference in overall survival (OS), progress‐free survival (PFS), and cancer‐specific survival (CSS) between patients with high CRP and those without. The pooled odds ratio (OR) with 95% CI were used to assess the association between CRP and clinicopathological features.ResultsA total of 17 studies, including 4449 patients, were included. Pooled results showed that an elevated CRP was associated with worse OS (HR = 1.48, 95% CI: 1.24‐1.77), CSS (HR = 1.85, 95% CI: 1.38‐2.46), and PFS (HR = 1.73, 95% CI: 1.38‐2.17). Male patients, lymph node metastases, and higher tumor stage were related to elevated CRP level (OR = 1.67, 95% CI: 1.34‐2.09; OR = 2.40, 95% CI: 1.44‐3.99; OR = 1.39, 95% CI: 1.12‐1.74).ConclusionOur meta‐analysis demonstrated that an elevated pretreatment of CRP indicates poor prognosis in HNSCC. Therefore, CRP is an indicator of the prognosis of patients with HNSCC and can be recommended for assessing prognoses in clinical work.
Comparative nuclear matrix proteome analysis of skeletal muscle cells in different cellular states
Authors: Puri Deepika , Swamy Ch V. B. , Dhawan Jyotsna , Mishra Rakesh K. 
Published: November 2020

AbstractThe nuclear matrix (NuMat) serves as the structural framework for organizing and maintaining nuclear architecture, however, the mechanisms by which this non‐chromatin compartment is constructed and regulated are poorly understood. This study presents a proteomic analysis of the NuMat isolated from cultured skeletal muscle cells in three distinct cellular states— proliferating myoblasts (MBs), terminally differentiated myotubes (MTs), and mitotically quiescent (G0) myoblasts. About 40% of the proteins identified were found to be common in the NuMat proteome of these morphologically and functionally distinct cell states. These proteins, termed as the “core NuMat,” define the stable, conserved, structural constituent of the nucleus, with functions such as RNA splicing, cytoskeletal organization, and chromatin modification, while the remaining NuMat proteins showed cell‐state specificity, consistent with a more dynamic and potentially regulatory function. Specifically, myoblast NuMat was enriched in cell cycle, DNA replication and repair proteins, myotube NuMat in muscle differentiation and muscle function proteins, while G0 NuMat was enriched in metabolic, transcription, and transport proteins. These findings offer a new perspective for a cell‐state‐specific role of nuclear architecture and spatial organization, integrated with diverse cellular processes, and implicate NuMat proteins in the control of the cell cycle, lineage commitment, and differentiation.
Potential role of NGF, BDNF, and their receptors in oligodendrocytes differentiation from neural stem cell: An in vitro study
Authors: Langhnoja Jaldeep , Buch Lipi , Pillai Prakash 
Published: November 2020

AbstractNeural stem cells (NSCs) or neuronal progenitor cells are cells capable of differentiating into oligodendrocytes, myelin‐forming cells that have the potential of remyelination. Brain‐derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are two neurotrophic factors that have been studied to stimulate NSC differentiation thus playing a role in multiple sclerosis pathogenesis and several other demyelinating disorders. While several studies have demonstrated the proliferative and protective capabilities of these neurotrophic factors, their cellular and molecular functions are still not well understood. Thus, in the present study, we focus on understanding the role of these neurotrophins (BDNF and NGF) in oligodendrogenesis from NSCs. Both neurotrophic factors have been shown to promote NSC proliferation and NSC differentiation particularly into oligodendroglial lineage in a dose‐dependent fashion. Further, to establish the role of these neurotrophins in NSC differentiation, we have employed pharmacological inhibitors for TrkA and TrkB receptors in NSCs. The use of these inhibitors suppressed NSC differentiation into oligodendrocytes along with the downregulation of phosphorylated ERK suggesting active involvement of ERK in the functioning of these neurotrophins. The morphometric analysis also revealed the important role of both neurotrophins in oligodendrocytes development. These findings highlight the importance of neurotrophic factors in stimulating NSC differentiation and may pave a role for future studies to develop neurotrophic factor replacement therapies to achieve remyelination.
Ring‐opening of azetidiniums by nucleophiles. Synthesis of polysubstituted linear amines
Authors: Masson Guillaume , Gomez Pardo Domingo , Cossy Janine 
Published: November 2020

AbstractThis microreview focuses on the nucleophilic ring‐opening of azetidiniums presenting various substitution patterns at C2, C3, and C4. In most cases, the nucleophilic ring‐opening occurred in a stereoselective and regioselective fashion producing functionalized linear amines. Experimental selectivities associated with Density Functional Theory (DFT) calculations have allowed a better understanding of the parameters governing the regioselectivities.
Young people's narratives of hearing voices: Systemic influences and conceptual challenges
Authors: Parry Sarah , Loren Eve , Varese Filippo 
Published: November 2020

AbstractDespite the prevalence of voice hearing in childhood and adolescence, little qualitative research has been undertaken with young people directly to advance phenomenological and aetiological insights into their experiences and interpretations. Consequently, the researchers sought demographic, contextual, and qualitative data from 74 young people from eleven countries, aged 13–18 years (28% = male; 61% = female; 21% = Transgender and Gender Non‐Binary [TGNB]), who self‐identified as hearing voices. A Foucauldian‐informed narrative analysis yielded four analytic chapters, offering novel perspectives into individual, relational, systemic, and cultural interpretative narratives surrounding multisensory and multi‐self voice hearing. Overall, young people reported heterogenous experiences of voice hearing and associated sensory experiences, and most participants reported voice hearing beginning between ages 8 and 11. Further, the emotions felt by the child, as well as reactions displayed by people around the child in relation to the voices, influenced voice‐related distress and the nature of the voices in a triadic relationship. A continuum of multisensory features of voice content, nature, and relational significance is tentatively proposed to capture the breadth and depth of voice hearing for adolescents to offer a possible framework for future study and intervention design. Specifically, participants described that voice‐related distress could be exacerbated by observed anxiety or internalized stigma about voice hearing, social isolation, and attribution to illness. These findings suggest that we may need to reconsider how the experience of hearing voices in childhood influences their relationships and how relationships influence the voice hearing experience. Further, young people seem to have a broad understanding of what the term “hearing voices” means, which could inform how researchers and practitioners work with this group of young people. Finally, participants described benefitting from multisensory coping strategies, such as imagery and meditation, which could offer important considerations for tailoring therapeutic interventions for adolescent voice hearers.
Spatio‐temporal trends in caries: A study on children in Berlin‐Mitte
Authors: Lee Ae Kyung , Aigner Annette , Schmid Timo , Kurth Tobias 
Published: November 2020

AbstractBackgroundSignificant inequalities in caries distribution among children in Germany have been reported, but small‐scale areas remain understudied.AimTo examine spatio‐temporal trends in children's dental caries at the small‐area level in Berlin‐Mitte.DesignRoutinely collected data from Berlin's annual Health Examination Surveys were used, which also include information on age, sex, country of origin, and residential area. The study population consists of 14,866 children aged 5 to 7 between 2006 and 2014 in the district of Berlin‐Mitte. Outcome variables are the dmft (decayed, missing, and filled teeth), the presence of any caries experience, untreated caries, and caries risk. The outcomes are summarized descriptively and graphically presented for 10 quarters and 41 communities within Berlin‐Mitte.ResultsRelevant gaps in children's dental caries were discovered between the quarters of Mitte. Three quarters in the northeast part of Mitte have consistently indicated the lowest oral health status in all four outcomes, and children having high caries risk have been increasingly concentrating in this area over time. Despite the continuous improvements in the southern part, the averages in total of Mitte for all outcomes have risen.ConclusionOur findings confirm the spatiotemporally mounting disparities in children's oral health between the quarters in Berlin‐Mitte and that particular quarters need urgent attention. The small‐area approach made it easier and more effective to reveal the spatial distribution of children's dental caries at the local level. The small‐area analysis should be strongly encouraged in future caries research to narrow the inequalities in children's oral health.
Carbon Dioxide Conversion Upgraded by Host‐guest Cooperation between Nitrogen‐Rich Covalent Organic Framework and Imidazolium‐Based Ionic Polymer
Authors: Zhong Hong , Gao Jinwei , Sa Rongjian , Yang Shuailong , Wu Zhicheng , Wang Ruihu 
Published: November 2020

AbstractInvited for this month's cover are the groups of Rongjian Sa and Ruihu Wang at Minjiang University and the Chinese Academy of Sciences. The image shows how host–guest composite catalysts with task‐specific components for the cycloaddition of CO2 with epoxides have been developed through integrating nitrogen‐rich covalent organic framework and imidazolium‐based ionic polymer. The Full Paper itself is available at 10.1002/cssc.202006158.
Editorial for the Special Issue of ChemSusChem on Green Carbon Science: CO2 Capture and Conversion
Authors: Su Bao‐Lian , Han Buxing , Liu Haichao , Sun Licheng , Xie Zai‐Ku 
Published: November 2020

AbstractIn their Editorial to the Special Issue on Green Carbon Science: CO2 Capture and Conversion, Guest Editors Bao‐Lian Su, Buxing Han, Haichao Liu, Licheng Sun, and Zai‐Ku Xie introduce the concept of green carbon science and discuss some of the Special Issue's contents.