bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracranial Hypertension and Intra-abdominal Pressure. Is it Worth Measuring?
Authors: Bonatto Simonei , Matias Danielle Pacheco , Welling Leonardo Christiaan 
Published: June 2020

AbstractPatients with refractory intracranial hypertension who have already undergone all the measures recommended by the current guidelines can benefit from having their intra-abdominal pressure monitored since its increase generates hemodynamic repercussions and secondary elevation of intracranial pressure. In this context, a bibliographic research was performed on PubMed with the terms intra-abdominal pressure, abdominal compartment syndrome, intracranial pressure, intracranial hypertension. Altogether, 146 articles were observed, 87 of which were from the year 2000, and only 15 articles were considered relevant to the topic. These studies indicate that patients with refractory intracranial hypertension can benefit from the measurement of intraabdominal pressure, since there is evidence that an increase in this pressure leads to organic dysfunctions with an indirect impact on cerebral venous return and, consequently, an increase in intracranial pressure. In those who underwent decompression laparotomy, direct effects were observed in reducing intracranial hypertension and survival.
Resection of a Nonampullary Adenoma with the New Gastroduodenal Full-Thickness Resection Device
Authors: Gericke Maximilian , Mende Matthias , Hartmann Dirk , Faiss Siegbert 
Published: June 2020

Abstract
Introduction Surgical resection of adenomas or subepithelial tumors in the duodenum has a high morbidity compared with endoscopic resection which also has a significant risk of complication. Endoscopic full-thickness resection has shown its feasibility and safety in the colorectum and in the upper gastrointestinal tract.
Patient and Methods We present the new gastroduodenal full-thickness resection device (FTRD) for full-thickness resection in a patient with a recurrent nonlifting adenoma in the nonampullary duodenum.
Results The procedure was successful with R0 resection without major complications. A control gastroscopy showed no recurrence of the adenoma.
Conclusion The gastroduodenal FTRD seems to be a promising new technique for resecting nonlifting adenomas in the nonampullary duodenum.
Real-time monitoring of the in vivo redox state transition using the ratiometric redox state sensor protein FROG/B
Authors: Sugiura Kazunori , Mihara Shoko , Fu Nae , Hisabori Toru 
Published: June 2020

Significance
In photosynthetic organisms, for example, the redox state of various molecules is altered by photosynthetic reactions. Thus, efficient monitoring of the redox state in living cells provides very important information for understanding the activity of the cell. For this purpose, we have designed a redox sensor protein based on the excited-state intramolecular proton transfer (ESIPT) mechanism. The protein having a single excitation peak and a double variable emission peak was named fluorescent protein with redox-dependent change in green/blue (FROG/B). It is just like a green frog that changes its body color according to the environment. This sensor protein allowed us to monitor the real-time redox changes of cyanobacterial cells caused by light/dark transition.
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex
Authors: Malinauskas Tomas , Peer Tina V. , Bishop Benjamin , Mueller Thomas D. , Siebold Christian 
Published: June 2020

Significance
Repulsive guidance molecules (RGMs) are cell surface proteins that control processes ranging from brain development to iron metabolism. Dysregulation of RGM function leads to severe diseases. RGMs can bind to the cell guidance receptor Neogenin (NEO1) and act as coreceptors for the bone morphogenetic proteins (BMPs). Here, we determined high-resolution structures of all three human RGMs in complex with the BMP ligand growth differentiation factor 5 (GDF5) and the ternary complex of GDF5 with RGM and NEO1. Our structural and functional analyses reveal that RGM competes with the GDF5 receptor. This study shows that RGMs can act as inhibitors of a BMP ligand (GDF5), and not always as activators of BMP signaling, as previously reported.
Precious metal recovery from electronic waste by a porous porphyrin polymer
Authors: Hong Yeongran , Thirion Damien , Subramanian Saravanan , Yoo Mi , Choi Hyuk , Kim Hyun You , Stoddart J. Fraser , Yavuz Cafer T. 
Published: June 2020

SignificanceElectronic waste, also called e-waste, is rapidly becoming a major industrial hazard because of the increased use of circuits and screens. With the right technology, however, this waste could become a sustainable source for precious metals. Such a solution requires selectivity toward the precious metals, as this characteristic is even more important than capacity. A porphyrin-based porous polymer with selective binding shows remarkable selectivity and a reductive mechanism, a combination which makes for record-high recycling of precious metals––particularly gold––from e-waste.
Slower nutrient stream suppresses Subarctic Atlantic Ocean biological productivity in global warming
Authors: Whitt Daniel B. , Jansen Malte F. 
Published: June 2020

Significance
Global warming drives cascading changes across physical, chemical, and biological marine systems. However, the coupled dynamics of these systems are difficult to disentangle. Here, we present a simple theoretical model of how these systems respond to global warming in the Subarctic Atlantic Ocean, which experiences particularly dramatic changes in 21st-century warming scenarios. The results reveal how global warming impacts this system by showing that remote changes in the Atlantic basin-scale circulation are a more important driver of biogeochemical change in the Subarctic than local reductions in vertical mixing.
The C terminus of p73 is essential for hippocampal development
Authors: Amelio Ivano , Panatta Emanuele , Niklison-Chirou Maria Victoria , Steinert Joern R. , Agostini Massimiliano , Morone Nobuhiro , Knight Richard A. , Melino Gerry 
Published: June 2020

Significance
Alteration of splicing is emerging as a relevant cause of human disease. The C-terminal region of p73 is subject to complex alternative splicing that can give rise to seven different isoforms. Here, using a newly generated mouse model, we determine the functional consequence of in vivo ectopic switch from the physiologically expressed and most abundant isoform p73α to the shorter p73β isoform. Expression of p73β leads to neurodevelopmental defects with functional and morphological abnormalities in the mouse hippocampus. The ectopic isoform switch results in depletion of Cajal–Retzius (CR) neurons in embryonic stages, leading to aberrant hippocampal architecture. Our study indicates that deregulation in p73 alternative splicing might underlie neurodevelopmental human conditions.
Evolution-inspired design of multicolored photoswitches from a single cyanobacteriochrome scaffold
Authors: Fushimi Keiji , Hasegawa Masumi , Ito Takeru , Rockwell Nathan C. , Enomoto Gen , -Win Ni-Ni , Lagarias J. Clark , Ikeuchi Masahiko , Narikawa Rei 
Published: June 2020

Significance
Cyanobacteriochromes (CBCRs) are small cyanobacterial photoreceptors which are highly diversified and categorized into many lineages based on their primary sequences. In this study, we identified an atypical CBCR exhibiting an orange/green reversible photocycle. Step-by-step site-directed mutagenesis was performed on this native CBCR, and seven new photoconvertible variants were created. During this process, we identified residues crucial for each color tuning event. These seven molecules covering the shorter-wavelength blue-to-orange region would contribute to the future development of multicolored optogenetic tools and are complementary to recently developed molecules sensing longer wavelengths of light.
Peroxidasin-mediated bromine enrichment of basement membranes
Authors: He Cuiwen , Song Wenxin , Weston Thomas A. , Tran Caitlyn , Kurtz Ira , Zuckerman Jonathan E. , Guagliardo Paul , Miner Jeffrey H. , Ivanov Sergey V. , Bougoure Jeremy , Hudson Billy G. , Colon Selene , Voziyan Paul A. , Bhave Gautam , Fong Loren G. , Young Stephen G. , Jiang Haibo 
Published: June 2020

SignificanceBromine is an essential trace element, required for the formation of sulfilimine cross-links in collagen IV, a basement membrane protein. Sulfilimine cross-link formation depends on the production of hypobromous acid by peroxidasin. Once the cross-links are formed, bromide is released, but we suspected that hypobromous acid might brominate bystander molecules in the basement membrane. NanoSIMS imaging of mouse kidneys revealed peroxidasin-dependent bromine enrichment in the basement membrane, and proteomics studies uncovered peroxidasin-dependent bromination of a specific tyrosine in collagen IV. Our studies show that bromine, an essential element, is largely restricted to basement membranes in mammalian tissues. Our studies also show that peroxidasin brominates bystander tyrosines in addition to promoting the formation of collagen IV sulfilimine cross-links.
Temperature-dependent kinetic pathways featuring distinctive thermal-activation mechanisms in structural evolution of ice VII
Authors: Lin Chuanlong , Liu Xuqiang , Yong Xue , Tse John S. , S. Smith Jesse , J. English Niall , Wang Bihan , Li Mei , Yang Wenge , Mao Ho-Kwang 
Published: June 2020

Significance
The kinetics of the structural evolution from crystalline ice (ice VII or ice VIII) toward thermodynamically stable ice I at ambient pressure have been characterized using time-resolved in situ X-ray diffraction. The time resolution captures events that were not observed previously and reveals a complex kinetic pathway with three distinctive transitions, i.e., amorphization, amorphous–amorphous, and crystallization of amorphous ice into ice I. The first two transitions exhibit different thermally activated mechanism above and below 110 K. Molecular-dynamics simulations show the transition involves a large change in density and substantial displacements of water at the nanoscale. This study presents a perspective on the metastability and complexity of the energy landscape in temperature/time-dependent structural evolution in amorphous ices.
Crisis Marketing through conceptual ontology in metaphor in financial reporting
Authors: O’Mara-Shimek Michael 
Published: June 2020

Abstract
This chapter explores basic ethical questions and implications of using metaphor in financial news reporting during crisis scenarios, and the relationship between these uses and common ideals and industry standards for journalism excellence. This research defends that Right to Information (RTI) provides a practical approach for discussing metaphor’s congruence with such ideals towards a more transparent and reliable financial journalism in times of market uncertainty. This work also argues that an RTI informed perspective on metaphor analysis enriches the central assumptions and commitments of Critical Discourse Analysis (CDA) involving power dynamics and justice in society through discourse: RTI informed uses of metaphor in crisis reporting is an offshoot of the central human right to information.
From economic crisis to austerity policies through conceptual metaphor
Authors: Soares da Silva Augusto 
Published: June 2020

Abstract
This chapter analyses the role of conceptual metaphors in the conceptualization and ideological exploitation of the global financial crisis and the subsequent austerity policies in the Portuguese press. The analysis relies on a corpus of news and opinion articles published between September 2008 and March 2009, when the financial breakdown that led to the global economic crisis took place, in June-July 2011, after the entry of the Troika in Portugal and the announcement of the first austerity measures, and May 2013, when protests against the austerity policies intensified. Assuming the general frameworks of Cognitive Linguistics and Critical Discourse Analysis and corpus-based and discourse-based approaches to conceptual metaphor, the study highlights how metaphor can be a powerful conceptual and discourse strategy to frame economic, political and social issues and to serve emotional and ideological purposes.
Responding to organisational misbehaviour
Authors: Holmgreen Lise-Lotte 
Published: June 2020

Abstract
Over the past decades, the seriousness with which organisational crises have developed has, in part, been contingent on public access to social media platforms. Analysing two Danish organisational crises, the chapter explores whether the conceptual repertoires that underlie public evaluation of organisational behaviour are embedded in shared social and cultural practices that allow them to be expressed and shared easily and intuitively. The findings suggest that by drawing on well-established experiential domains in social and cultural life, users in public social media may instantiate frames that inspire other users to follow suit. This may create dominant interpretations across platforms and lay the foundation of crisis development.
Framing the onset of obsessive-compulsive disorder (OCD)
Authors: Knapton Olivia 
Published: June 2020

Abstract
Despite quantitative research showing differences between obsessive-compulsive disorder (OCD) across genders, little research has qualitatively explored women’s experiences of the disorder. This chapter combines image schemas with illness narrative analysis to explore how women with OCD link the onset of the disorder to traumatic changes in their bodies that are experienced as a crisis. It is argued that the bodily changes disrupt the image schemas that provide stable conceptualisations of the body. The disintegration of the stable body leads to conceptualisations of OCD that, to various degrees, frame OCD as an attempt to regain control over the changed body. Thus, the women make sense of OCD onset by connecting it to personal crises and relationships within specific sociocultural contexts.
Bilingualism, second language acquisition, and language contact
Authors: Geeslin Kimberly L. , Evans-Sago Travis 
Published: June 2020

Abstract
This chapter introduces the central issues and concepts in the fields of bilingualism, contact linguistics, and second language acquisition, with an eye to identifying generalizations and key distinctions. For example, although authors use terms like transfer, interference, bilinguals, etc., across fields, these sometimes have the same meaning and other times depend on the subfield of linguistics in which they are employed. While there is a good deal of overlap between these fields, the current chapter provides an overview of studies and findings related to these concepts in order to help orient the reader to the hypotheses, methodologies, and discussions contained in the present volume.
Origins and dialectology studies of Spanish in America
Authors: Díaz-Campos Manuel , Milla-Muñoz Ángel 
Published: June 2020

Abstract
This chapter offers a general perspective concerning the origins of American Spanish. This introductory chapter broadly includes the most relevant aspects that characterize Spanish varieties in South America. The first part reviews the influence of the settlers in the formation of Spanish in America. Additionally, contact situations with indigenous languages as well as the impact of African heritage are also investigated. The second part is dedicated to a description of the major dialectal areas in South America and their linguistic features. Departing from prior studies, the chapter depicts the most relevant phonetic and morphosyntactic phenomena. The chapter ends with some concluding remarks about the roots of Spanish in America and its independent developments in different regions of South America.
Amazonian Spanish and the emergence and maintenance of ethnolinguistic variation
Authors: Lamanna Scott 
Published: June 2020

Abstract
This chapter outlines various linguistic phenomena involved in the creation and transmission of ethnolinguistic variation, as a general framework for understanding Amazonian Spanish specifically. Language and dialect contact, second language acquisition, bilingualism, and language shift have all played important roles in the emergence and maintenance of ethnicity-based language varieties around the world, and Amazonian Spanish is certainly no exception. The chapter considers the potential explanatory value of the concept of an ethnolinguistic repertoire (Benor, 2010) when accounting for patterns of variation observed in Amazonian Spanish, and also points out the need to examine the interaction between ethnicity and other relevant social factors such as age, gender, and social class (Wolfram & Schilling, 2016) as speakers index their multifaceted identities.
Clitics and argument marking in Shipibo-Spanish and Ashéninka-Perené-Spanish bilingual speech
Authors: Sánchez Liliana , Mayer Elisabeth 
Published: June 2020

Abstract
Direct object clitics in Spanish are morphological markers at the interface of syntax and phonology, morphology, semantics and information structure. We explore variability in direct object clitic doubling and argument marking in bilingual speakers of Shipibo-Spanish and Ashéninka-Perené-Spanish (Mayer & Sánchez, in press). We focus on the production of the dative versus the accusative forms of the clitic and on the expression of Differential Object Marking (DOM) (Aissen, 2003; Bossong, 1985, 1991; Dalrymple & Nikolaeva, 2011), in particular, on the extension of DOM to definite inanimate DPs and the lack of DOM with animate direct objects required in other varieties of Spanish. We analyze this variability as the coexistence of two different argument-marking systems in these contact varieties of Amazonian Spanish.
Emerging ethnolinguistic varieties in the Amazon
Authors: Fafulas Stephen , Viñas-de-Puig Ricard 
Published: June 2020

Abstract
We analyze a handful of morphosyntactic features of Yagua Spanish (YS), a contact variety of Spanish spoken in the Amazon. Our results, from sociolinguistic interviews and film narrations conducted with 10 YS speakers from Comandancia, located along Peru’s Orosa River, suggest that YS is characterized by significant occurrence of leísmo, null direct objects, and non-canonical use of the Present Perfect. Analyses based on language proficiency reveal that the Yagua-dominant bilinguals, who learned Spanish primarily as adults, show higher rates of these non-pan-Latin American forms as compared to the Spanish-dominant bilinguals who acquired Spanish earlier in life. We explore the origins of these linguistic features and add to what is known of emerging varieties of Spanish in the Amazon region.
Phonological processes in flux
Authors: O'Rourke Erin 
Published: June 2020

Abstract
In this study, we examine the production of the palatal lateral in Spanish, represented orthographically as <ll>, as produced by bilinguals in the Ecuadorian Amazon. The purpose of this study is first to observe what changes may have taken place in the acoustic production of palatal /ʎ/ by Quichua-Spanish speakers in comparison to related segments /l/ and /ʝ/ which may be due to indigenous language contact, and second to determine if extralinguistic influences may have contributed to this change (e.g., differences in gender). While males appear to maintain a distinct palatal lateral and females demonstrate a move towards delateralization, both genders demonstrate cases of depalatalization due to allophony, as in their native language.
Does CLIL promoteintercultural sensitivity?
Authors: Lochtman Katja 
Published: June 2020

Abstract
Content and Language Integrated Learning (CLIL) refers to the teaching of non-linguistic subjects through an
additional language. Culture is considered as one of the corner stones of CLIL pedagogy. There is currently
little research that explores the role of culture or intercultural sensitivity in CLIL, however. The present study investigates to
what extent two different educational contexts (CLIL and non-CLIL) influence students’ level of intercultural sensitivity, using
the Intercultural Sensitivity Scale (Chen & Starosta, 2000). The sample consists of
177 secondary grammar school students from 2 CLIL schools (n = 98) and 2 non-CLIL / regular schools
(n = 79). The results show that intercultural sensitivity is not as self-evident as one may expect in a CLIL
setting. Some other factors come into play, i.e. gender, language background and school grade.
Preparing students for intentional conversations with older adults
Authors: McAllister Margaret , Dodd Leanne , Ryan Colleen , Brien Donna Lee 
Published: June 2020

AbstractThis paper presents the findings from a study introducing nursing students to narrative production. The aim was to use Story Theory to inspire students to intentionally collaborate with older people and produce a mini-biography of those individuals. Narrative theory was utilised in four ways: designing an educational intervention; collecting and developing older peoples’ life stories; framing an understanding of the meaning of the stories collected; analysing the significance of the storytelling approach. The paper explains the study approach and findings and outlines the benefits as well as challenges that occurred during the process. Most particularly, the anthology produced has become a tangible reminder about a clinical practice that allowed students to meet frail aged residents and come to know them as vibrant human beings.
On the dynamic interaction between peritext and epitext
Authors: Tyrkkö Jukka , Räikkönen Jenni 
Published: June 2020

Abstract
Originally introduced in literary theory, Gerard Genette’s concept of paratext has been increasingly adopted in historical linguistics as a collective term for features other than the so-called ‘body text’. While this development and the renewed attention to these features is welcome, we argue that Genette’s original concept has been simplified and at least partly misrepresented in the linguistic context. Using a newly compiled corpus of Punch magazine as our primary data, we discuss how and why the two constituent terms of paratext, peritext and epitext, can be useful in the linguistic context. More specifically, we demonstrate that when considered from a diachronic perspective, the interactions between the concepts may afford new insights into textual interpretation.
Framing material in early literacy
Authors: Lenker Ursula 
Published: June 2020

Abstract
The remarkably extensive and diverse Anglo-Saxon text corpus clearly testifies to the literary precocity and self-awareness of both writers and book producers in Anglo-Saxon England, the first period of literacy in English. This becomes particularly evident in prologues and scribal colophons, the two kinds of framing material discussed in the present chapter. Clearly modelled on classical or early Christian genre conventions, the famous Alfredian and Ælfrician prologues frame the reading of the following vernacular texts by investing them with the authority implicit in Latin literacy. At the end of texts or manuscripts, scribal colophons exploit the value of manuscripts as material objects, by presenting the – in a manuscript culture typically individual – agents of literacy, namely the book and its producer(s). Similar in their formal characteristics to maker formulae in epigraphy, colophons further serve independent functions in keeping the names of the scribes in remembrance through the centuries. Both kinds of framing material thus attest to the authorial and medial (self-)awareness of the agents of Anglo-Saxon literacy, who understood the great potential of the written medium to carry authority and to secure longevity.