bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Lettuce Plant in Spring and Autumn Period, Effects of Led Lightening on the Quantity of Mineral Substrates and Leaf Nitrate
Authors: Ataklı Seda Bice , Şahin Sezer 
Published: December 2019

Aims: This study was performed during early spring and winter period of 2015-2016 by utilizing soilles technique in a non-heated glasshouse that belongs to Gaziosmanpaşa University Faculty of Agriculture.
Study Design: Whereas Funly F1 lettuce species was used as vegetal materials, 2:1 ratio cocopeat and perlite mixture was used as cultivation environment. According to the experiment design, experiment coincidence parcels were performed as 3-recurrences. In the experiment, the effects of different colored LED lights (blue, yellow, red, blue + yellow, blue + red, yellow + red, blue + yellow + red) additional to sunlight were examined.
Results: SMD strip LEDs with different colors were used as light source. The light practice does not affect on the plant diameter, plant lenght, SÇKM, pH, titered acid, vitamin C and plant nutrient concentrations. Statistically significant difference occured in the yield of spring and winter curly leaf head salad. There was also an increase at 1% importance level in the light practices compared to the control. In the experiment, red and red blue light combinations had an increase of 1% in the curly leaf head salads in the yield rate when it was compared to the control. Whereas the highest total plant head weight was 840 gr/piece in spring practice, and it was 732 gr/piece for the red light practices in winter practice. Compared to the control, the amount of plant leaf nitrate for the light practices resulted in a decrease at 1% importance level in the curly leaf head salad. When the results were compared with the control conditions, the lowest nitrate contents were obtained as 1764.5 mg NO3-kg- in spring practices, 1898.6 NO3-kg- in winter practices.
Coclusion: More amount of nitrate was observed on the leaves of curly leaf head salad in winter practice compared to the one in spring. The amount of leaf nitrate decreased in the light practices compared to the control. As a result, the red and blue light practices and their combinations improved the amount of yield and plant growth by reducing nitrate content.
Astrovirus Gastroenteritis in Children Younger than 5 Years in Ouagadougou (Burkina Faso): Prevalence and Risks Factors Influencing Severity
Authors: Gamsonré Zakaria , Bisseye Cyrille , Nitiema Léon W. , Diarra Birama , Zohoncon Théodora M. , Tao Issoufou , Compaoré Tegwindé Rebeca , Djigma Florencia W. , Ouermi Djénéba , Nordgren Johan , Pietra Virginio , Simporé Jacques 
Published: December 2019

Aims: The aim of this study was to investigate the prevalence of astrovirus infections and associated risks factors.
Methods: A prospective study was undertaken from May 2009 to March 2010, covering the rainy and dry seasons, at the Saint Camille Medical Center in Ouagadougou, Burkina Faso. A total of 213 non hospitalized children less than 5 years of age with diarrhea were enrolled and examined for astrovirus, others enteropathogens, and clinico-epidemiological aspects.
Results: Astroviruses prevalence among the enrolled children was 14.6%. Astrovirus infections were common during the cold dry season from December to February (38.7%), during the rainy season from June to September (54.8%), also during dry season in March (3.2%) and May (3.2%). Children younger than 11 months of age were most affected by astroviruses (16%). Moderate and severe malnutrition influenced more severe symptoms of astrovirus related diarrheas.
Conclusion: The present study shows that astroviruses have an important role in pediatric viral-associated diarrhea in Burkina Faso. Diarrhea is more severe in malnourished children.
La implementación de las políticas cinematográficas en Colombia y los cambios en los arreglos organizacionales
Authors: Mancilla Liceth Viviana Rivera , Baldi Mariana 
Published: December 2019

<p>Este trabajo presenta los cambios en los arreglos organizacionales consecuentes de los cambios en las políticas públicas cinematográficas, desde el surgimiento del cine en Colombia hasta el 2018. La investigación se basó en la recopilación de datos secundarios y entrevistas utilizando el método de análisis de contenido, con foco principalmente en los cambios ocurridos a partir del 2003. Desde la Ley 814 del 2003, la cinematografía colombiana presentó un gran crecimiento y, en ese proceso, se crearon diferentes arreglos organizacionales. Los nuevos órganos Estatales y entes ejecutores (Ministerio de Cultura, Dirección de Cinematografía, Proimágenes Colombia, Retina Latina) y las nuevas leyes (Ley General de Cultura, Ley de Cine 814 de 2003, Ley de Filmación 1556 de 2012), han conseguido mantener una producción continua de películas a lo largo de los años. </p>
Impact of image preprocessing methods on reproducibility of radiomic features in multimodal magnetic resonance imaging in glioblastoma
Authors: Moradmand Hajar , Aghamiri Seyed Mahmoud Reza , Ghaderi Reza 
Published: December 2019

AbstractTo investigate the effect of image preprocessing, in respect to intensity inhomogeneity correction and noise filtering, on the robustness and reproducibility of the radiomics features extracted from the Glioblastoma (GBM) tumor in multimodal MR images (mMRI). In this study, for each patient 1461 radiomics features were extracted from GBM subregions (i.e., edema, necrosis, enhancement, and tumor) of mMRI (i.e., FLAIR, T1, T1C, and T2) volumes for five preprocessing combinations (in total 116 880 radiomics features). The robustness and reproducibility of the radiomics features were assessed under four comparisons: (a) Baseline versus modified bias field; (b) Baseline versus modified bias field followed by noise filtering; (c) Baseline versus modified noise, and (d) Baseline versus modified noise followed bias field correction. The concordance correlation coefficient (CCC), dynamic range (DR), and interclass correlation coefficient (ICC) were used as metrics. Shape features and subsequently, local binary pattern (LBP) filtered images were highly stable and reproducible against bias field correction and noise filtering in all measurements. In all MRI modalities, necrosis regions (NC: n ̅ ~449/1461, 30%) had the highest number of highly robust features, with CCC and DR >= 0.9, in comparison with edema (ED: n ̅ ~296/1461, 20%), enhanced (EN: n ̅ ~ 281/1461, 19%) and active‐tumor regions (TM: n ̅ ~254/1461, 17%). The necrosis regions (NC: ~ 449/1461, 30%) had a higher number of highly robust features (CCC and DR >= 0.9) than edema (ED: ~ 296/1461, 20%), enhanced (EN: ~ 281/1461, 19%) and active‐tumor (TM: ~ 254/1461, 17%) regions across all modalities. Furthermore, our results identified that the percentage of high reproducible features with ICC >= 0.9 after bias field correction (23.2%), and bias field correction followed by noise filtering (22.4%) were higher in contrast with noise smoothing and also noise smoothing follow by bias correction. These preliminary findings imply that preprocessing sequences can also have a significant impact on the robustness and reproducibility of mMRI‐based radiomics features and identification of generalizable and consistent preprocessing algorithms is a pivotal step before imposing radiomics biomarkers into the clinic for GBM patients.
Dynamic conformal arcs for lung stereotactic body radiation therapy: A comparison with volumetric‐modulated arc therapy
Authors: Bokrantz Rasmus , Wedenberg Minna , Sandwall Peter 
Published: December 2019

AbstractThis study constitutes a feasibility assessment of dynamic conformal arc (DCA) therapy as an alternative to volumetric‐modulated arc therapy (VMAT) for stereotactic body radiation therapy (SBRT) of lung cancer. The rationale for DCA is lower geometric complexity and hence reduced risk for interplay errors induced by respiratory motion. Forward planned DCA and inverse planned DCA based on segment‐weight optimization were compared to VMAT for single arc treatments of five lung patients. Analysis of dose‐volume histograms and clinical goal fulfillment revealed that DCA can generate satisfactory and near equivalent dosimetric quality to VMAT, except for complex tumor geometries. Segment‐weight optimized DCA provided spatial dose distributions qualitatively similar to those for VMAT. Our results show that DCA, and particularly segment‐weight optimized DCA, may be an attractive alternative to VMAT for lung SBRT treatments if the patient anatomy is favorable.
First FHM3 mouse model shows spontaneous cortical spreading depolarizations
Authors: Jansen Nico A. , Dehghani Anisa , Linssen Margot M. L. , Breukel Cor , Tolner Else A. , van den Maagdenberg Arn M. J. M. 
Published: December 2019

AbstractHere we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated NaV1.1 sodium channels (Scn1aL263V). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.
Modus Operandi of Simultaneous Covering Synthesis from Precursor Heterogeneity for Shelled Nanorods for Multipotent Cancer Theranostics
Authors: Yim Gyeonghye , Kang Seounghun , Kim Hyungjun , Kim Young‐Jin , Gil Yeong‐Gyu , Kim Young‐Kwan , Min Dal‐Hee , Jang Hongje 
Published: December 2019

AbstractThe synthesis of nanostructures using homogeneous precursors in the solution phase is widely used to achieve uniformity and well‐defined morphological control. However, drawbacks such as the lack of diversity due to the limited reaction rate modulation exist. One‐step, core–shell nanorod formation using simultaneous covering synthesis using solid and ionic heterogeneous precursors is proposed in this study. A Te‐Bi2Te3/TeO2 core–shell structure is successfully synthesized by precisely controlling various influencing factors, including concentration, temperature, and pH, and its physicochemical and photochemical properties are thoroughly investigated. The proposed nanostructure overcomes the oxidation susceptibility of Te and can be applied to multipotent cancer theranostics in vitro and in vivo in combination with computed tomography imaging.
Atomically Dispersed Co–P3 on CdS Nanorods with Electron‐Rich Feature Boosts Photocatalysis
Authors: Zhou Peng , Zhang Qinghua , Xu Zhikun , Shang Qiuyu , Wang Liang , Chao Yuguang , Li Yiju , Chen Hui , Lv Fan , Zhang Qing , Gu Lin , Guo Shaojun 
Published: December 2019

AbstractThe development of highly efficient photocatalytic systems with rapid photogenerated charge separation and high surface catalytic activity is highly desirable for the storage and conversion of solar energy, yet remains a grand challenge. Herein, a conceptionally new form of atomically dispersed Co–P3 species on CdS nanorods (CoPSA‐CdS) is designed and synthesized for achieving unprecedented photocatalytic activity for the dehydrogenation of formic acid (FA) to hydrogen. X‐ray absorption near edge structure, X‐ray photoelectron spectroscopy, and time‐resolved photoluminescence results confirm that the Co–P3 species have a unique electron‐rich feature, greatly improving the efficiency of photogenerated charge separation through an interface charge effect. The in situ attenuated total reflection infrared spectra reveal that the Co–P3 species can achieve much better dissociation adsorption of FA and activation of CH bonds than traditional sulfur‐coordinated Co single atom‐loaded CdS nanorods (CoSSA‐CdS). These two new features make CoPSA‐CdS exhibit the unprecedented 50‐fold higher activity in the photocatalytic dehydrogenation of FA than CoSSA‐CdS, and also much better activity than the Ru‐, Rh‐, Pd‐, or Pt‐loaded CdS. Besides, CoPSA‐CdS also shows the highest mass activity (34309 mmol gCo−1 h−1) of Co reported to date. First‐principles simulation reveals that the Co–P3 species herein can form an active PHCOO intermediate for enhancing the rate‐determining dissociation adsorption of FA.
Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci
Authors: Céspedes María Virtudes , Cano‐Garrido Olivia , Álamo Patricia , Sala Rita , Gallardo Alberto , Serna Naroa , Falgàs Aïda , Voltà‐Durán Eric , Casanova Isolda , Sánchez‐Chardi Alejandro , López‐Laguna Hèctor , Sánchez‐García Laura , Sánchez Julieta M. , Unzueta Ugutz , Vázquez Esther , Mangues Ramón , Villaverde Antonio 
Published: December 2019

AbstractFunctional amyloids produced in bacteria as nanoscale inclusion bodies are intriguing but poorly explored protein materials with wide therapeutic potential. Since they release functional polypeptides under physiological conditions, these materials can be potentially tailored as mimetic of secretory granules for slow systemic delivery of smart protein drugs. To explore this possibility, bacterial inclusion bodies formed by a self‐assembled, tumor‐targeted Pseudomonas exotoxin (PE24) are administered subcutaneously in mouse models of human metastatic colorectal cancer, for sustained secretion of tumor‐targeted therapeutic nanoparticles. These proteins are functionalized with a peptidic ligand of CXCR4, a chemokine receptor overexpressed in metastatic cancer stem cells that confers high selective cytotoxicity in vitro and in vivo. In the mouse models of human colorectal cancer, time‐deferred anticancer activity is detected after the subcutaneous deposition of 500 µg of PE24‐based amyloids, which promotes a dramatic arrest of tumor growth in the absence of side toxicity. In addition, long‐term prevention of lymphatic, hematogenous, and peritoneal metastases is achieved. These results reveal the biomedical potential and versatility of bacterial inclusion bodies as novel tunable secretory materials usable in delivery, and they also instruct how therapeutic proteins, even with high functional and structural complexity, can be packaged in this convenient format.
Efficiency and Stability Enhancement of Fully Ambient Air Processed Perovskite Solar Cells Using TiO2 Paste with Tunable Pore Structure
Authors: Seyed‐Talebi Seyedeh Mozhgan , Kazeminezhad Iraj , Shahbazi Saeed , Diau Eric Wei‐Guang 
Published: December 2019

AbstractCrystallization and nucleation of the perovskite layer in the mesoscopic perovskite solar cells (PSCs) depend on the nucleation sites of the electron transport layer (ETL). The porosity optimization of TiO2 film as an efficient ETL plays an important role in the performance improvement of PSCs. In the present study, nontoxic carbon spheres synthesized with uniform morphology and controllable size under hydrothermal conditions and used as a template to generate the tunable porous TiO2 films. Furthermore, the effect of porosity modification of TiO2 on the formation of perovskite films with large grain size is studied in an ambient atmosphere with humidity higher than 50%. The best TiO2 film is produced with carbon spheres 8 wt% (C8), which results in the formation of a pinhole‐free, and compact‐packed perovskite layer. The fully air processed PSC device with the ETL made of C8 film exhibits an efficiency of 16.66% with reduced hysteresis, which is much superior in performance compared to the standard cell (11.72%). It is believed that this porosity optimization of TiO2 layer is a simple practical strategy for improved stability of fully air processed efficient perovskite solar cells and usable for the fabrication of reproducible compact perovskite layers in uncontrolled laboratories.
Underwater Adhesion of Multiresponsive Complex Coacervates
Authors: Dompé Marco , Cedano‐Serrano Francisco J. , Vahdati Mehdi , van Westerveld Larissa , Hourdet Dominique , Creton Costantino , van der Gucht Jasper , Kodger Thomas , Kamperman Marleen 
Published: December 2019

AbstractMany marine organisms have developed adhesives that are able to bond under water, overcoming the challenges associated with wet adhesion. A key element in the processing of several natural underwater glues is complex coacervation, a liquid–liquid phase separation driven by complexation of oppositely charged macromolecules. Inspired by these examples, the development of a fully synthetic complex coacervate‐based adhesive is reported with an in situ setting mechanism, which can be triggered by a change in temperature and/or a change in ionic strength. The adhesive consists of a matrix of oppositely charged polyelectrolytes that are modified with thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) grafts. The adhesive, which initially starts out as a fluid complex coacervate with limited adhesion at room temperature and high ionic strength, transitions into a viscoelastic solid upon an increase in temperature and/or a decrease in the salt concentration of the environment. Consequently, the thermoresponsive chains self‐associate into hydrophobic domains and/or the polyelectrolyte matrix contracts, without inducing any macroscopic shrinking. The presence of PNIPAM favors energy dissipation by softening the material and by allowing crack blunting. The high work of adhesion, the gelation kinetics, and the easy tunability of the system make it a potential candidate for soft tissue adhesion in physiological environments.
Two unrelated pedigrees with achondrogenesis type 1b carrying a Japan‐specific pathogenic variant in SLC26A2
Authors: Sato Taisuke , Kojima Takashi , Samura Osamu , Kawaguchi Satoshi , Nakamura Akie , Nakajima Masahiro , Tanuma‐Takahashi Akiko , Nakabayashi Kazuhiko , Hata Kenichiro , Ikegawa Shiro , Nishimura Gen , Okamoto Aikou , Yamada Takahiro 
Published: December 2019

AbstractWe present two unrelated Japanese pedigrees with achondrogenesis type 1b (ACG1B), characterized by prenatally lethal fetal hydrops and severe micromelia. The affected members in these pedigrees carried a common homozygous missense point mutation in solute carrier family 26 member 2 (SLC26A2), a gene associated with ACG1B (NM_000112:c.1987G>A). This loss‐of‐function point mutation causes substitution of glycine 663 with arginine in a highly conserved loop domain of SLC26A2. Interestingly, only a few cases of this mutation have been registered in Japanese genomic databases, and there are no reports of this mutation in any major genomic databases outside Japan. Furthermore, we confirmed the presence of a homozygous stretch of approximately 75 kb surrounding the pathogenic variant. Our findings suggest that this missense point mutation in SLC26A2, which is likely the cause of the ACG1B phenotypes in these unrelated fetuses, is distributed exclusively in Japan.
Molybdenum Carbide‐Oxide Heterostructures: In Situ Surface Reconfiguration toward Efficient Electrocatalytic Hydrogen Evolution
Authors: He Liuqing , Zhang Wenbiao , Mo Qijie , Huang Wenjie , Yang Lichun , Gao Qingsheng 
Published: December 2019

AbstractHeterostructured Mo2C‐MoOx on carbon cloth (Mo2C‐MoOx/CC), as a model of easily oxidized electrocatalysts under ambient conditions, is investigated to uncover surface reconfiguration during the hydrogen evolution reaction (HER). Raman spectroscopy combined with electrochemical tests demonstrates that the MoVI oxides on the surface are in situ reduced to MoIV, accomplishing promoted HER in acidic condition. As indicated by density functional theoretical calculations, the in situ reduced surface with terminal Mo=O moieties can effectively bring the negative ΔGH* on bare Mo2C close to a thermodynamic neutral value, addressing difficult H* desorption toward fast HER kinetics. The optimized Mo2C‐MoOx/CC only requires a low overpotential (η10) of 60 mV at −10 mA cm−2 in 1.0 m HClO4, outperforming Mo2C/CC and most non‐precious electrocatalysts. In situ surface reconfiguration are shown on W2C‐WOx, highlighting the significance to boost various metal‐carbides and to identify active sites.
Photoinduzierte Protonentransferreaktionen für milde O‐H‐Funktionalisierungsreaktionen unreaktiver Alkohole
Authors: Jana Sripati , Yang Zhen , Li Fang , Empel Claire , Ho Junming , Koenigs Rene M. 
Published: December 2019

AbstractIn der organischen Synthese wird Hexafluorisopropanol üblicherweise als nicht reaktives Lösungsmittel und nicht als Reagens angesehen. In diesem Artikel berichten wir über die photochemische Reaktion von Aryldiazoacetaten mit Hexafluorisopropanol, die unter stöchiometrischen Bedingungen die milde und effiziente Synthese von fluorierten Ethern in hervorragender Ausbeute ermöglicht. In mechanistischen Studien konnten wir feststellen, dass eine Präorganisation von Hexafluorisopropanol und dem Diazoalkan unter Ausbildung eines unreaktiven Wasserstoffbrückenbindungskomplexes stattfindet. Dieser Komplex geht erst nach photochemischer Anregung eine Protonierungs‐Substitutionsreaktion zum Reaktionsprodukt ein. Abschließend führten wir Untersuchungen zur Anwendbarkeit dieser photochemischen Umwandlung durch und konnten zeigen, dass eine große Vielfalt acider Alkohole in dieser Reaktion eingesetzt werden können und damit die Machbarkeit dieses Konzepts in O‐H‐Funktionalisierungsreaktionen demonstrieren (54 Beispiele, bis zu 98 % Ausbeute).
Metal–Organic Frameworks as Metal Ion Precursors for the Synthesis of Nanocomposites for Lithium‐Ion Batteries
Authors: Li Hongfeng , Wu Peng , Xiao Yawen , Shao Meng , Shen Yu , Fan Yun , Chen Huanhuan , Xie Ruijie , Zhang Wenlei , Li Sheng , Wu Jiansheng , Fu Yu , Zheng Bing , Zhang Weina , Huo Fengwei 
Published: December 2019

AbstractMetal–organic frameworks (MOFs) are promising materials with fascinating properties. Their widespread applications are sometimes hindered by the intrinsic instability of frameworks. However, this instability of MOFs can also be exploited for useful purposes. Herein, we report the use of MOFs as metal ion precursors for constructing functional nanocomposites by utilizing the instability of MOFs. The heterogeneous growth process of nanostructures on substrates involves the release of metal ions, nucleation on substrates, and formation of a covering structure. Specifically, the synthesized CoS with carbon nanotubes as substrates display enhanced performance in a lithium‐ion battery. Such strategy not only presents a new way for exploiting the instability of MOFs but also supplies a prospect for designing versatile functional nanocomposites.
Cooperative Carbon Dioxide Adsorption in Alcoholamine‐ and Alkoxyalkylamine‐Functionalized Metal–Organic Frameworks
Authors: Mao Victor Y. , Milner Phillip J. , Lee Jung‐Hoon , Forse Alexander C. , Kim Eugene J. , Siegelman Rebecca L. , McGuirk C. Michael , Zasada Leo B. , Neaton Jeffrey B. , Reimer Jeffrey A. , Long Jeffrey R. 
Published: December 2019

AbstractA series of structurally diverse alcoholamine‐ and alkoxyalkylamine‐functionalized variants of the metal–organic framework Mg2(dobpdc) are shown to adsorb CO2selectively via cooperative chain‐forming mechanisms. Solid‐state NMR spectra and optimized structures obtained from van der Waals‐corrected density functional theory calculations indicate that the adsorption profiles can be attributed to the formation of carbamic acid or ammonium carbamate chains that are stabilized by hydrogen bonding interactions within the framework pores. These findings significantly expand the scope of chemical functionalities that can be utilized to design cooperative CO2adsorbents, providing further means of optimizing these powerful materials for energy‐efficient CO2separations.