bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term β-blocker therapy and clinical outcomes after acute myocardial infarction in patients without heart failure: nationwide cohort study
Authors: Kim Jihoon , Kang Danbee , Park Hyejeong , Kang Minwoong , Park Taek Kyu , Lee Joo Myung , Yang Jeong Hoon , Song Young Bin , Choi Jin-Ho , Choi Seung-Hyuk , Gwon Hyeon-Cheol , Guallar Eliseo , Cho Juhee , Hahn Joo-Yong 
Published: April 2020

Abstract

Aims
To investigate the association between long-term β-blocker therapy and clinical outcomes in patients without heart failure (HF) after acute myocardial infarction (AMI).

Method and results
Between 2010 and 2015, a total of 28 970 patients who underwent coronary revascularization for AMI with β-blocker prescription at hospital discharge and were event-free from death, recurrent myocardial infarction (MI), or HF for 1 year were enrolled from Korean nationwide medical insurance data. The primary outcome was all-cause death. The secondary outcomes were recurrent MI, hospitalization for new HF, and a composite of all-cause death, recurrent MI, or hospitalization for new HF. Outcomes were compared between β-blocker therapy for ≥1 year (N = 22 707) and β-blocker therapy for &lt;1 year (N = 6263) using landmark analysis at 1 year after index MI. Compared with patients receiving β-blocker therapy for &lt;1 year, those receiving β-blocker therapy for ≥1 year had significantly lower risks of all-cause death [adjusted hazard ratio (HR) 0.81; 95% confidence interval (CI) 0.72–0.91] and composite of all-cause death, recurrent MI, or hospitalization for new HF (adjusted HR 0.82; 95% CI 0.75–0.89), but not the risks of recurrent MI or hospitalization for new HF. The lower risk of all-cause death associated with persistent β-blocker therapy was observed beyond 2 years (adjusted HR 0.86; 95% CI 0.75–0.99) but not beyond 3 years (adjusted HR 0.87; 95% CI 0.73–1.03) after MI.

Conclusion
In this nationwide cohort, β-blocker therapy for ≥1 year after MI was associated with reduced all-cause death among patients with AMI without HF.
Orthogonal P-wave morphology, conventional P-wave indices, and the risk of atrial fibrillation in the general population using data from the Finnish Hospital Discharge Register
Authors: Eranti Antti , Carlson Jonas , Kenttä Tuomas , Holmqvist Fredrik , Holkeri Arttu , Haukilahti M Anette , Kerola Tuomas , Aro Aapo L , Rissanen Harri , Noponen Kai , Seppänen Tapio , Knekt Paul , Heliövaara Markku , Huikuri Heikki V , Junttila M Juhani , Platonov Pyotr G 
Published: April 2020

Abstract

Aims
Identifying subjects at high and low risk of atrial fibrillation (AF) is of interest. This study aims to assess the risk of AF associated with electrocardiographic (ECG) markers linked to atrial fibrosis: P-wave prolongation, 3rd-degree interatrial block, P-terminal force in lead V1, and orthogonal P-wave morphology.

Methods and results
P-wave parameters were assessed in a representative Finnish population sample aged ≥30 years (n = 7217, 46.0% male, mean age 51.4 years). Subjects (n = 5489) with a readable ECG including the orthogonal leads, sinus rhythm, and a predefined orthogonal P-wave morphology type [positive in leads X and Y and either negative (Type 1) or ± biphasic (Type 2) in lead Z; Type 3 defined as positive in lead X and ± biphasic in lead Y], were followed 10 years from the baseline examinations (performed 1978–80). Subjects discharged with AF diagnosis after any-cause hospitalization (n = 124) were defined as having developed AF. Third-degree interatrial block was defined as P-wave ≥120 ms and the presence of ≥2 ± biphasic P waves in the inferior leads. Hazard ratios (HRs) and confidence intervals (CIs) were assessed with Cox models. Third-degree interatrial block (n = 103, HR 3.18, 95% CI 1.66–6.13; P = 0.001) and Type 3 morphology (n = 216, HR 3.01, 95% CI 1.66–5.45; P &lt; 0.001) were independently associated with the risk of hospitalization with AF. Subjects with P-wave &lt;110 ms and Type 1 morphology (n = 2074) were at low risk (HR 0.46, 95% CI 0.26–0.83; P = 0.006), compared to the rest of the subjects.

Conclusion
P-wave parameters associate with the risk of hospitalization with AF.
The Impact of Late-Life Disability Spectrum on Depressive Symptoms: A Fixed-Effects Analysis of Panel Data
Authors: Xiang Xiaoling , Yang Yong , Cheng Jianjia , An Ruopeng 
Published: April 2020

Abstract

Objectives
This study examines the impact of a previously validated disability spectrum that accounts for compensatory strategies on depressive symptoms in older adults.

Methods
This study was a secondary data analysis of 2011 through 2018 surveys from the National Health and Aging Trends Study (N = 7,609). The disability spectrum was categorized using a 5-level hierarchical scheme: fully able, successful accommodation, reduced activity, difficulty, and assistance for 12 mobility, self-care, and household activities. The individual fixed-effects panel model was used to examine the impact of this disability spectrum on depressive symptoms.

Results
Depressive symptoms rose progressively with each successive category on the disability spectrum in descriptive analyses. In fixed-effects models, moving from “fully able” to “successful accommodation” was not associated with significant changes in depressive symptoms; this result held for all self-care and mobility activities. Moving from “fully able” to “reduced activity” was associated with a significant increase in depressive symptoms for 3 household activities (doing laundry, making hot meals, and shopping for groceries) but not for paying bills/banking or keeping track of medications. Going up 2 or more stages above “fully able” on the disability spectrum was associated with a significant increase in depressive symptoms across all 12 activities.

Discussion
While limitations in a range of daily activities have harmful effects on mental health, using compensatory strategies that do not erode one’s perception of autonomy can help older adults cope with the psychological detriments of late-life disability.
Reformulation of Parker–Oldenburg's method for Earth's spherical approximation
Authors: Chen Wenjin , Tenzer Robert 
Published: April 2020

SUMMARY
Parker–Oldenburg's method is perhaps the most commonly used technique to estimate the depth of density interface from gravity data. To account for large density variations reported, for instance, at the Moho interface, between the ocean seawater density and marine sediments, or between sediments and the underlying bedrock, some authors extended this method for variable density models. Parker–Oldenburg's method is suitable for local studies, given that a functional relationship between gravity data and interface geometry is derived for Earth's planar approximation. The application of this method in (large-scale) regional, continental or global studies is, however, practically restricted by errors due to disregarding Earth's sphericity. Parker–Oldenburg's method was, therefore, reformulated also for Earth's spherical approximation, but assuming only a uniform density. The importance of taking into consideration density heterogeneities at the interface becomes even more relevant in the context of (large-scale) regional or global studies. To address this issue, we generalize Parker–Oldenburg's method (defined for a spherical coordinate system) for the depth of heterogeneous density interface. Furthermore, we extend our definitions for gravity gradient data of which use in geoscience applications increased considerably, especially after launching the Gravity field and steady-state Ocean Circulation Explorer (GOCE) gravity-gradiometry satellite mission. For completeness, we also provide expressions for potential. The study provides the most complete review of Parker–Oldenburg's method in planar and spherical cases defined for potential, gravity and gravity gradient, while incorporating either uniform or heterogeneous density model at the interface. To improve a numerical efficiency of gravimetric forward modelling and inversion, described in terms of spherical harmonics of Earth's gravity field and interface geometry, we use the fast Fourier transform technique for spherical harmonic analysis and synthesis. The (newly derived) functional models are tested numerically. Our results over a (large-scale) regional study area confirm that the consideration of a global integration and Earth's sphericty improves results of a gravimetric forward modelling and inversion.
Propagation of EBV-driven Lymphomatous Transformation of Peripheral Blood B Cells by Immunomodulators and Biologics Used in the Treatment of Inflammatory Bowel Disease
Authors: Levhar Nina , Ungar Bella , Kopylov Uri , Fudim Ella , Yavzori Miri , Picard Orit , Amariglio Ninette , Chowers Yehuda , Shemer-Avni Yonat , Mao Ren , Chen Min-hu , Ye Ziyin , Eliakim Rami , Ben-Horin Shomron 
Published: April 2020

Abstract

Background
Immunomodulators and anti tumor-necrosis-α antibodies (anti-TNFs) have been implicated in increased risk of Epstein–Barr virus (EBV)–driven B-cell lymphoproliferative disorders in inflammatory bowel disease (IBD) patients. However, the underlying mechanisms are poorly understood.

Methods
An in-vitro model of lymphoblastoid cell line (LCL) was established by co-incubation of EBV-infected human peripheral blood mononuclear cells (PBMC) with Cyclosporin-A (CSA). After 4 weeks, the resultant LCLs were analyzed by flow cytometry, telomerase activity assay, and next generation sequencing. Subsequently, LCLs were explored in the presence of therapeutic agents for IBD (anti-TNFs, vedolizumab, 6-Mercaptopurine [6MP], methotrexate). Epstein–Barr virus titers were quantitated by real-time polymerase chain reaction.

Results
In cultures of PBMC with EBV and CSA, LCLs were characterized as an expanded, long lived population of CD58+CD23hi B-cells with high telomerase activity and clonal expansion. Upon addition to the cell cultures, LCL percentages were higher with infliximab (median 19.21%, P = 0.011), adalimumab (median 19.85%, P = 0.003), and early washed-out 6MP (median 30.57%, P = 0.043) compared with PBMC with EBV alone (median 9.61%). However, vedolizumab had no such effect (median 8.97%; P = 0.435). Additionally, LCL expansion was accompanied by increase in intracellular, rather than extracellular, EBV viral copies. Compared with PBMC with EBV alone, high levels of LCL were subsequently observed after triple depletion of NK cells, CD4+ T cells, and CD8+ T cells (median 52.8% vs 16.4%; P = 0.046) but also in cultures depleted solely of CD4+ T cells (median 30.7%, P = 0.046).

Conclusions
These results suggest that both anti-TNFs and 6MP, but not vedolizumab, propagate EBV-driven lymphoblastoid transformation in an in vitro model of lymphoma. This model may prove useful for studying mechanisms underlying proneoplastic viral immune interactions of novel drugs in IBD therapy.
Portfolio risk and the quantum majorization of correlation matrices
Authors: Fontanari Andrea , Eliazar Iddo , Cirillo Pasquale , Oosterlee Cornelis W 
Published: April 2020

Abstract
We propose quantum majorization as a way of comparing and ranking correlation matrices, with the aim of assessing portfolio risk in a unified framework. Quantum majorization is a partial order in the space of correlation matrices, which are evaluated through their spectra. We discuss the connections between quantum majorization and an important class of risk functionals, and we define two new risk measures able to capture interesting characteristics of portfolio risk.
Oral cephalosporin and β-lactamase inhibitor combinations for ESBL-producing Enterobacteriaceae urinary tract infections
Authors: Stewart Adam G , Harris Patrick N A , Henderson Andrew , Schembri Mark A , Paterson David L 
Published: April 2020

AbstractESBL-producing Enterobacteriaceae as uropathogens have given rise to a sizeable amount of global morbidity. Community and hospital surveillance studies continue to report increasing proportions of these organisms as causes of urinary tract infection (UTI). Due to limited treatment options and the presence of cross-resistance amongst oral antibiotics of different classes, patients often require IV therapy, thereby increasing healthcare costs and reducing the effectiveness of delivering healthcare. Oral cephalosporin antibiotics are well known for their ability to achieve high urinary concentrations, in addition to achieving clinical success for treatment of uncomplicated UTI with a drug-susceptible pathogen. Novel cephalosporin/β-lactamase inhibitor combinations have been developed and demonstrate good in vitro activity against ESBL-producing isolates. A pooled analysis of in vitro activity of existing oral cephalosporin/clavulanate combinations in ESBL-producing Enterobacteriaceae has shown MIC50s of 0.5–1, 0.125–1 and 0.25 mg/L for cefpodoxime, ceftibuten and cefixime, respectively. A novel cyclic boronic acid β-lactamase inhibitor, QPX7728, was able to produce MIC50 values of 0.5 and ≤0.06 mg/L when paired with cefpodoxime and ceftibuten, respectively. Other novel combinations, cefpodoxime/ETX0282 and ceftibuten/VNRX7145, have also demonstrated excellent activity against ESBL producers. Clinical trials are now awaited.
Evaluation of a Genetic Sexing Strain of the Oriental Fruit Fly as a Candidate for Simultaneous Application of Male Annihilation and Sterile Insect Techniques (Diptera: Tephritidae)
Authors: Shelly Todd E 
Published: April 2020

AbstractThe oriental fruit fly, Bactrocera dorsalis (Hendel), is an important pest of fruits and vegetables, and many countries operate surveillance programs to detect infestations and, if needed, implement costly control efforts. The Male Annihilation Technique (MAT), which involves deployment of the male lure methyl eugenol (ME) to reduce or eliminate the male population, has been used as a stand-alone strategy or as a precursor to the Sterile Insect Technique (SIT), which involves the release of sterile males to generate sterile male by wild female crosses and the production of inviable progeny. Modeling suggests that simultaneous implementation of MAT and SIT, rather than sequential deployment, increases the probability of successful eradication. Previous research has shown that B. dorsalis males that have fed on ME show reduced tendency to re-visit ME sources. Also, males fed ME gain a mating advantage over nonfed males. The goal of the present study was to evaluate the suitability of a genetic sexing strain of B. dorsalis as a candidate for concurrent implementation of MAT and SIT. Evaluation focused on the timing of prerelease exposure to methyl eugenol to identify the male age at which feeding upon the lure both i) reduces postrelease attraction to ME-baited traps (thus allowing the operation of MAT) and ii) enhances postrelease mating competitiveness (thus increasing the effectiveness of SIT). Results indicate that prerelease ME feeding by 6-d-old males, with release the following day, would allow effective, concurrent implementation of MAT and SIT.
Color Preference of Three Parasitoids Imported to the Americas for the Biological Control of the Coffee Berry Borer (Curculionidae: Scolytinae)
Authors: Castillo Alfredo , Rojas Julio C 
Published: April 2020

AbstractThe African parasitoids Cephalonomia stephanoderis Waterston (Bethylidae: Hymenoptera), Prorops nasuta Betrem (Bethylidae: Hymenoptera), and Phymastichus coffea LaSalle (Eulophidae: Hymenoptera) are biological control agents of the coffee berry borer (Coleoptera: Curculionidae). In this study, we investigated in laboratory the female behavioral responses of these parasitoids to 14 different wavelengths (340–670 nm) against a control (570 nm, yellow). When nonchooser females were included in the analysis, none parasitoids species showed a preference between 340, 350, 370, 460, 490, 520, 540, 590, 640, and 650 nm with respect to the control wavelength. In contrast, the three species of parasitoids were more attracted to wavelengths of 380, 400, and 420 nm than the control wavelength. Phymastichus coffea and P. nasuta were more attracted to the wavelength of 400 and 420 nm compared to C. stephanoderis. At 380 nm, P. coffea and C. stephanoderis wasps showed the higher responses in comparison to P. nasuta females. When nonchooser wasps were excluded from the analysis, we observed other differences among the parasitoid species. For instance, P. coffea were more attracted to 490–540 nm than to 570 nm, whereas the bethylids did not discriminate between 490–540 nm or 570 nm. Our results are discussed in relation to possible implications associated with the vision of these parasitoid species.
Effect of Winning Experience on Aggression Involving Dangerous Fighting Behavior in Anastatus disparis (Hymenoptera: Eupelmidae)
Authors: Liu Peng-Cheng , Hao De-Jun , Hu Hao-Yuan , Wei Jian-Rong , Wu Fan , Shen Jie , Xu Shen-jia , Xie Qi-Yue 
Published: April 2020

Abstract
Aggressive behavior is widely observed in animal species for acquiring important resources and usually includes both dangerous and nondangerous fighting patterns. Only a few species show dangerous fighting patterns that are defined by fights ending with contestants being severely injured or killed. Prior experience, an important factor in many species, has been demonstrated to affect a contestant’s subsequent fighting behavior. Few studies have focused on the effect of experience on aggression involving dangerous fighting patterns. Here, an egg parasitoid wasp, Anastatus disparis, which shows extreme and dangerous fighting behavior to acquire mating opportunities, was used as an experimental model. Our results showed that the fighting intensity of the winning males significantly decreased subsequent fighting behavior, which was inconsistent with general predictions. Transcriptomic analyses showed that many genes related to energy metabolism were downregulated in winners, and winners increased their fighting intensity after dietary supplementation. Our study suggested that fighting in A. disparis is a tremendous drain on energy. Thus, although males won at combat, significant reductions in available energy constrained the intensity of subsequent fights and influenced strategic decisions. In addition, winners might improve their fighting skills and abilities from previous contests, and their fighting intensity after dietary supplementation was significantly higher than that of males without any fighting experience. Generally, in A. disparis, although winners increased their fighting ability with previous experience, the available energy in winners was likely to be a crucial factor affecting the intensity and strategic decisions in subsequent fights.
Oral and Topical Insecticide Response Bioassays and Associated Statistical Analyses Used Commonly in Veterinary and Medical Entomology
Authors: Burgess Edwin R , King Bethia H , Geden Christopher J 
Published: April 2020

Abstract
Veterinary and medical entomologists who are involved in research on pest control often need to perform dose–response bioassays and analyze the results. This article is meant as a beginner’s guide for doing this and includes instructions for using the free program R for the analyses. The bioassays and analyses are described using previously unpublished data from bioassays on house flies, Musca domestica Linnaeus (Diptera: Muscidae), but can be used on a wide range of pest species. Flies were exposed topically to beta-cyfluthrin, a pyrethroid, or exposed to spinosad or spinetoram in sugar to encourage consumption. LD50 values for beta-cyfluthrin in a susceptible strain were similar regardless of whether mortality was assessed at 24 or 48 h, consistent with it being a relatively quick-acting insecticide. Based on LC50 values, spinetoram was about twice as toxic as spinosad in a susceptible strain, suggesting a benefit to formulating spinetoram for house fly control, although spinetoram was no more toxic than spinosad for a pyrethroid-resistant strain. Results were consistent with previous reports of spinosad exhibiting little cross-resistance. For both spinosad and spinetoram, LC50 values were not greatly different between the pyrethroid-resistant strain and the susceptible strain.
Rickettsia spp. in Five Tick Species Collected in Central California
Authors: Osborne Cameron J , Wakeman-Hill Alya J , Loa Steven E , Crosbie Paul R , Van Laar Tricia A 
Published: April 2020

AbstractTick-borne disease surveillance in North America has long focused on Lyme disease, though there is currently a significant shift towards comprehensive pathogen surveillance in ticks. Central California has often been overlooked in regular tick-borne pathogen surveillance despite the presence of numerous medically important tick species. The bacterial genus Rickettsia contains tick-borne species that are known pathogens, such as those in the spotted fever group; nonpathogenic endosymbionts; and many species with unknown pathogenic potential. Five common tick species (Ixodes pacificus Cooley and Kohls [Acari: Ixodidae], Dermacentor occidentalis Marx [Acari: Ixodidae], D. variabilis Say, Rhipicephalus sanguineus Latreille [Acari: Ixodidae], and Ornithodoros parkeri Cooley [Acari: Argasidae]) of California were collected by both traditional and modern techniques, and subsequently screened for Rickettsia spp. Many individuals from all five tick species were PCR positive for Rickettsia spp., and a combination of species-specific primers, a restriction fragment length polymorphism assay, and DNA sequencing was used to further characterize the species composition in these ticks. Probable Rickettsia philipii (Rickettsia 364D) was detected in one (1.56%) D. occidentalis collected in Fresno County; R. rhipicephali was detected in 23.4% of D. occidentalis from Fresno Co.; R. bellii was detected in 88.2% of D. variabilis, 7.8% of D. occidentalis, and in one R. rhipicephalus (1.1%) from Fresno Co.; R. monacensis str. Humboldt was detected in three (100%) of I. pacificus collected in both Fresno and Madera Co.; and an uncharacterized Rickettsia was detected in (26.4%) of O. parkeri collected in both Fresno and Madera Co. The findings in this study highlight the need for ongoing surveillance in this region of California.
Postcolonial Reflexivity in the News Industry: The Case of Foreign Correspondents in Kenya and South Africa
Authors: Nothias Toussaint 
Published: April 2020

AbstractOver the past 30 years, scholars have criticized the propensity of the international media to reproduce damaging and racist stereotypes about Africa. How do foreign correspondents, who are key actors in the production of Africa's media image, position themselves in relation to this criticism? Based on 35 interviews conducted with correspondents in Kenya and South Africa between 2013 and 2017, I find that many correspondents recognize the negative contributions of the news industry to representational Othering, thereby agreeing with the general tenets of the criticism. This paper is an in-depth exploration of this phenomenon, which I call postcolonial reflexivity. I outline the features of this postcolonial reflexivity, discuss its impact on journalistic practices, and explore the reasons for its prevalence among correspondents. Overall, the research contributes to bridging the gap between the textual orientation of postcolonial studies and the inclination for analyzing production practices in journalism studies.