bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI PEMBELAJARAN BERBASIS MASALAH PADA MATA PELAJARAN PKn DALAM MENINGKATKAN KREATIVITAS PESERTA DIDIK DI SMAN 3 PROBOLINGGO
Authors: Basit Abdul , Sapriya Sapriya 
Published: May 2020

ABSTRACT
This research is purposed by to describe the efforts of schools in improving the creativity of learners in the subject of Civics through the implementation of PBL. The research methodology used in this research is a qualitative approach with descriptive methods. The research subjects are including principals, teachers, and learners. In collecting the data, the techniques used observation, interviews, and documentation. Data were analyzed using data reduction, data presentation and conclusion/verification. The result of this research shows that the efforts of the school and the principal's role in enhancing the creativity of learners are maximal. It can be proved in the provision of opportunities for learners to explore and to develop the potential and capabilities they had. Schools also provide programs "foster friends" with the purpose diminishes the administrative burden of students, especially those from poor families.
Keywords: Problem based learning, civic education, and creativity
MORAL HUKUM DAN NILAI-NILAI KEBANGSAAN: SEBUAH REFLEKSI PEMIKIRAN BUYA HAMKA
Authors: Fuad Fokky 
Published: May 2020

ABSTRACT
This study aims to analyze how Hamkaâ€™s thinking about nationality, as well as moral values in accordance with the legal system of the philosophy of Pancasila. The method used in this research is a normative legal research methods to approach concepts (conceptual approach). Hamkaâ€™s idea about national values are still relevant in developing the love for the homeland. Hamkaâ€™s thinking about nationality, religious and rejected the concept of secularization. He said God is the center of human strength established the nation. The spirit of divinity embodied in the form of patriotism needs to be instilled in every person. According to Hamka, philosophy Pancasila indicates the religious character of the Indonesian nation. Therefore, the implementation of law should be sourced from the religious philosophy of Pancasila. Recognition ofthe existence of God in the Pancasila should be realized in the form of legal which has religious values.
Keywords: Hamka, legal philosophy Pancasila, moral law
Feasibility and Evaluation of a Large-Scale External Validation Approach for Patient-Level Prediction in an International Data Network: Validation of models predicting stroke in female patients newly diagnosed with atrial fibrillation.
Authors: Reps Jenna Marie , Williams Ross D , You Seng Chan , Falconer Thomas , Minty Evan , Callahan Alison , Ryan Patrick B , Park Rae Woong , Lim Hong-Seok , Rijnbeek Peter 
Published: May 2020

Abstract
Background To demonstrate how the Observational Healthcare Data Science and Informatics (OHDSI) collaborative network and standardization can be utilized to scale-up external validation of patient-level prediction models by enabling validation across a large number of heterogeneous observational healthcare datasets.Methods Five previously published prognostic models (ATRIA, CHADS2, CHADS2VASC, Q-Stroke and Framingham) that predict future risk of stroke in patients with atrial fibrillation were replicated using the OHDSI frameworks. A network study was run that enabled the five models to be externally validated across nine observational healthcare datasets spanning three countries and five independent sites. Results The five existing models were able to be integrated into the OHDSI framework for patient-level prediction and they obtained mean c-statistics ranging between 0.57-0.63 across the 6 databases with sufficient data to predict stroke within 1 year of initial atrial fibrillation diagnosis for females with atrial fibrillation. This was comparable with existing validation studies. The validation network study was run across nine datasets within 60 days once the models were replicated. An R package for the study was published at https://github.com/OHDSI/StudyProtocolSandbox/tree/master/ExistingStrokeRiskExternalValidation .Conclusion This study demonstrates the ability to scale up external validation of patient-level prediction models using a collaboration of researchers and a data standardization that enable models to be readily shared across data sites. External validation is necessary to understand the transportability or reproducibility of a prediction model, but without collaborative approaches it can take three or more years for a model to be validated by one independent researcher. In this paper we show it is possible to both scale-up and speed-up external validation by showing how validation can be done across multiple databases in less than 2 months. We recommend that researchers developing new prediction models use the OHDSI network to externally validate their models.
Older adults' preferences for, adherence to and experiences of two self-management falls prevention home exercise programmes: A comparison between a digital programme and a paper booklet
Authors: Mansson Linda , Lundin-Olsson Lillemor , Skelton Dawn A , Janols Rebecka , Lindgren Helena , Rosendahl Erik , Sandlund Marlene 
Published: May 2020

Abstract
Background: Fall prevention exercise programmes are known to be effective, but access to these programmes is not always possible. The use of eHealth solutions might be a way forward to increase access and reach a wider population. In this feasibility study the aim was to explore the choice of programme, adherence, and self-reported experiences comparing two exercise programmes – a digital programme and a paper booklet.Methods: A participant preference trial of two self-managed fall prevention exercise interventions. Community-dwelling adults aged 70 years and older exercised independently for four months after one introduction meeting. Baseline information was collected at study start, including a short introduction of the exercise programme, a short physical assessment, and completion of questionnaires. During the four months intervention period, participants self-reported their performed exercises in an exercise diary. At a final meeting, questionnaires about their experiences, and post-assessments, were completed. For adherence analyses data from diaries were used and four subgroups for different levels of participation were compared. Exercise maintenance was followed up with a survey 12 months after study start.Results: Sixty-seven participants, with mean age 77±4 years were included, 72% were women. Forty-three percent chose the digital programme. Attrition rate was 17% in the digital programme group and 37% in the paper booklet group (p=.078). In both groups 50-59% reported exercise at least 75% of the intervention period. The only significant difference for adherence was in the subgroup that completed ≥75% of exercise duration, the digital programme users exercised more minutes per week (p=.001). Participants in both groups were content with their programme but digital programme users reported a significantly higher (p=.026) degree of being content, and feeling supported by the programme (p=.044). At 12 months follow-up 67% of participants using the digital programme continued to exercise regularly compared with 35% for the paper booklet (p=.036).Conclusions: Exercise interventions based on either a digital programme or a paper booklet can be used as a self-managed, independent fall prevention programme. There is a similar adherence in both programmes during a 4-month intervention, but the digital programme seems to facilitate long-term maintenance in regular exercise.Trial registration: ClinTrial: NCT02916849
Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)
Authors: Hurley Deirdre , Jeffares Isabelle , Hall Amanda M , Keogh Alison , Toomey Elaine , McArdle Danielle , McDonough Suzanne M , Guerin Suzanne , Segurado Ricardo , Matthews James 
Published: May 2020

Abstract
Background The Self-management of Osteoarthritis (OA) and Low back pain (LBP) through Activity and Skills (SOLAS) theory-driven group-based complex intervention was developed primarily for the evaluation of its acceptability to patients and physiotherapists and the feasibility of trial procedures, to inform the potential for a definitive trial. Methods This assessor-blinded multicentre two-arm parallel cluster randomised controlled feasibility trial compared the SOLAS intervention to usual individual physiotherapy (UP; pragmatic control group). Patients with OA of the hip, knee, lumbar spine and/or chronic LBP were recruited in primary care physiotherapy clinics (i.e. clusters) in Dublin, Ireland between September 2014 and November 2015. The primary feasibility objectives were evaluated using quantitative methods and individual telephone interviews with purposive samples of participants and physiotherapists. A range of secondary outcomes were collected at baseline, 6 weeks (behaviour change only), 2 months and 6 months to explore the preliminary effects of the intervention. Analysis was by intention-to-treat according to participants’ cluster allocation and involved descriptive analysis of the quantitative data and inductive thematic analysis of the qualitative interviews. A linear mixed model was used to contrast change over time in participant secondary outcomes between treatment arms, while adjusting for study waves and clusters. Results 14 clusters were recruited (7 per trial arm), each cluster participated in two waves of recruitment, with the average cluster size below the target of six participants (Intervention: mean (SD) =4.92 (1.31), range 2-7; UP: mean (SD) =5.08 (2.43), range 1-9). 120 participants (83.3% of n=144 expected) were recruited (Intervention n=59; UP n=61), with follow up data obtained from 80.8% (n=97) at 6 weeks, 84.2% (n=101) at 2 months and 71.7% (n=86) at 6 months. Most participants received treatment as allocated (Intervention n=49; UP n=54). The qualitative interviews (12 participants; 10 PTs) found the Intervention and trial procedures acceptable and appropriate, with minimal feasible adaptations required. Linear mixed methods showed improvements in most secondary outcomes at 2 and 6 months with small between group effects. Conclusions While the SOLAS intervention and trial procedures were acceptable to participants and PTs, the recruitment of enough participants is the biggest obstacle to a definitive trial. Trial Registration: ISRCTN Registry, ISRCTN49875385, Registered 26 March 2014. https://doi.org/10.1186/ISRCTN49875385
A comparative study of Long Interspersed Element-1 Protein Immunoreactivity in Cutaneous Malignancies
Authors: Zolfaghari Mohammad Ali , Karimi Abbas , Kalantari Elham , Korourian Alireza , Ghanadan Alireza , Kamyab Kambiz , Esmaili Nafiseh , Razavi Amir Nader Emami , Madjd Zahra 
Published: May 2020

Abstract
Background: Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The extent to which Long Interspersed Element-1 (LINE-1, L1) ORF1p is expressed in cutaneous malignancies remains to be evaluated. This study aimed to assess LINE-1 ORF1p immunoreactivity in various skin cancer subtypes. Method:The expression level of LINE-1 ORF1p was evaluated in 95 skin cancer specimens comprising 36 (37.9%) BCC, 28 (29.5%) SCC, and 31 (32.6%) melanoma using the tissue microarray (TMA) technique. Then the association between expression of LINE-1 encoded protein and clinicopathological parameters was analyzed. Results: We showed that LINE-1 ORF1p expression level was substantially higher in BCC and SCC patients compared with melanoma samples (p < 0.001). BCC cases had a higher LINE-1 histochemical score (H-score) compared with SCC cases (p = 0.004). In SCC samples, a lower level of LINE-1 ORF1p expression was associated with age younger than the mean (p = 0.041). At the same time, no significant correlation was found between LINE-1 ORF1p expression and other clinicopathological parameters (all p > 0.05). Conclusions: According to our observation, LINE-1 ORF1p immunoreactivity in various skin tumor subtypes extends previous studies of LINE-1 expression in different cancers. LINE-1ORF1p overexpression in NMSCs compared with MM can be considered with caution as a tumor-specific antigen for NMSCs.
The Role of Patient-provider Communication: a qualitative study of patient attitudes regarding co-occurring depression and chronic diseases in Malawi
Authors: Akiba Christopher , Zimba Chifundo C , Thom Annie , Matewere Maureen , Go Vivian , Pence Brian , Gaynes Bradley Neil , Masiye Jones 
Published: May 2020

Abstract
Background: Globally, depression is a leading cause of morbidity and mortality particularly in Low and Middle-Income Countries (LMICs). The burden of non-communicable diseases (NCDs) are also increasing in LMICs, the conditions frequently co-occur and exacerbate NCD outcomes. Depression interventions alone are not effective at improving NCD outcomes, resulting in wide-reaching calls for integrated services. Integrated services are in a nascent phase in LMICs in general and in Malawi in particular. This manuscript serves to clarify Malawian patients’ attitudes and perceptions towards depression integration into routine NCD services. Methods: Ten District Hospitals were selected for data collection and 2 participants were interviewed from each site (N=20). An iterative approach to concept-driven coding was applied to facilitate the formation of similarities, differences, and connections between codes. Results: While patients infrequently described moderate depression as a medical condition, and held various attitudes regarding treatments, they agreed on the appropriateness of integrated services. Patients’ respect for their providers led them to support integration. Patients discussed how medical knowledge is highly regarded, revealing a power dynamic with their providers. Patients further acknowledged the importance of a provider’s communication in shaping a patient’s feelings about depression. Conclusions: Training and interventions that facilitate providers’ abilities to transfer their medical knowledge, use strategies to channel their power, and engage patients in a meaningful and collaborative relationship will be key to successfully integrating depression treatment into Malawian NCD clinics. Trial Registration: This work served as part of formative data collection for National Institute of Mental Health (NIMH) Trail NCT03711786 registered on 10th October, 2018
Hospitalizations for viral respiratory infections in children under 2 years of age: epidemiology and in-hospital complications
Authors: Zurita-Cruz Jessie , Gutierrez-Gonzalez Alejandro , Manuel-Apolinar Leticia , Fernández-Gárate José Esteban , Arellano-Flores María Luisa , Eng Roberto Alejandro Correa Gonzalez , Vazquez-Rosales Guillermo , Sanchez-Armas Rocio , Cisneros Nelly 
Published: May 2020

Abstract
Background: Viral respiratory infections (VRIs) are a frequent cause of hospitalization in children under 24 months of age. A history of prematurity or heart disease may be a risk factor for complications in patients hospitalized for VRI. The objective was to describe epidemiological data for children hospitalized for IRV and aged 1 to 24 months and to identify risk factors for the presence of in-hospital complications and mortality over a period of 5 years. Methods : This was a cross-sectional study. Patients registered with VRI codes B974, J12, J120-J129X, J168, J17, J171, J178, J20, J203-J209, J21, J210, J211, J218, J219 (based on International Classification of Diseases [ICD-10]) from 2013 to 2017 were included. Three subanalyses were performed to compare (1) patients with pathological history (prematurity, bronchopulmonary dysplasia [BPD] and congenital heart disease [CHD]), (2) diagnoses (pneumonia, acute bronchitis, and acute bronchiolitis), and (3) admission to the pediatric intensive care unit. Days of hospital stay, in-hospital complications, invasive medical procedure and mortality were analyzed. Statistical analysis : VRI hospitalization prevalence was described. For comparison between groups, Student's t-test, ANOVA and the Chi2 test were applied. To identify factors related to days of hospital stay, in-hospital complications and mortality, a linear and logistic regression model was performed. Results: A total of 66,304 hospitalizations were reported. The average age was 14.7 weeks; hospitalization events were higher in winter (39%), followed by autumn (27.3%). A total of 371 (0.56%) patients died. A total of 7,068 (10.6%) hospitalized patients with pathological histories were identified. The presence of BPD (coefficient = 1.6), CHD (coefficient = 1.2), diagnosis of pneumonia (coefficient = 1.2), in-hospital complications (coefficient = 2.1) and invasive medical procedures (coefficient = 15.7) were the most common factors that increased the length of hospital stay. Risk factors for in-hospital complications and mortality were invasive medical procedure (OR = 3.3 & 11.7), BPD (OR=1.8 & 1.6), CHD (OR = 4.6 & 3.4) and diagnosis of pneumonia (OR= 1.8 & 4.2). Conclusions: Risk factors for morbidity and mortality in patients hospitalized for VRIs are BPD and CHD, diagnosis of pneumonia and invasive medical procedure.
A Tunisian version of the Confusion Assessment Method for the intensive care unit (CAM-ICU): translation and validation
Authors: Saida Imen Ben , Kortli Saiid , Amamou Badii , Kacem Nawres , Ghardallou Mariem , Ely Eugene Wesley , Saad Helmi Ben , Boussarsar Mohamed 
Published: May 2020

Abstract
Background. Delirium is common in critically ill patients and it is associated with poor outcomes. In Tunisia, however, it is still underdiagnosed as there is no validated screening tool. The aim of this study was to translate and to validate a Tunisian version of the CAM-ICU. Methods. For the validation and inter-rater reliability assessment of the Tunisian CAM-ICU, two trained intensivists independently evaluated delirium in the patients admitted to the ICU between October 2017 and June 2018. All the patients consecutively admitted to the ICU for more than 24 hours and having a Richmond Agitation-Sedation Scale greater than or equal to “-3” were assessed for delirium excluding those with stroke, dementia, psychosis or persistent coma. The results were compared with the reference evaluation carried out by a psychiatrist using the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria. The inter-rater reliability was calculated using the kappa (κ) statistic. The CAM-ICU concurrent validity was assessed using Cronbach’s α coefficient, sensitivity, specificity as well as positive and negative predictive values (PPV and NPV, respectively) for the two Tunisian CAM-ICU raters. Results. The study involved 137 patients [median (IQR) age: 60 [49-68] years, male sex (n=102), invasive mechanical ventilation (n=49)]. Using the DSM-V criteria evaluations, 46 patients were diagnosed with delirium. When applying the Tunisian version of the CAM-ICU, 38(27.7%) patients were diagnosed with delirium for the first rater and 45(32.6%) patients for the second one. The Tunisian CAM-ICU showed a very-high inter-rater reliability for both intensivists (κ = 0.844, p<0.001). Using the DSM-V rater as the reference standard, the sensitivity of the two intensivists’ evaluations was 80.4 vs. 95.7%. Specificity was 98.9% for both. The Cronbach’s α of the first and second raters’ evaluations using the Tunisian version of the CAM-ICU were 0.886 and 0.887, respectively. Conclusions. The Tunisian version of the CAM-ICU showed almost perfect validity and reliability in detecting delirium in critically ill patients. It could therefore be used in Tunisian ICUs or where Tunisian translators are available following appropriate training. Trial registration. Not applicable.
The circulating level of Non-coding RNA for breast cancer diagnosis
Authors: wang miao , gu yao , zhang jie , jia zhaojun , wu huijian 
Published: May 2020

Abstract
Background: The expression of non-coding RNAs were closely related to breast cancer progression. However, there were no systemic analysis of non-coding RNAs in breast cancer diagnosis of the blood circulatory system. Herein, we aimed to collect all the evidence to test the potential role of non-coding RNAs as novel biomarkers in human breast cancers. Methods: A comprehensive search strategy was used to search relevant literatures in the Web of Science, PubMed, and Embase databases from January 2012 to November 2019. The correlation of non-coding RNAs expression in serum, plasma or blood circulatory system and the diagnostic accuracy of BC markers were analyzed. The methodological quality of each study was assessed using the QUADAS-2. Statistical analysis was used the STATA (version 12.0), Meta-Disc (version 1.4) and Review Manager (version 5.3) software. Results: The present meta-analysis of the non-coding RNAs expression data of BC patients and healthy specimens’ bloodfrom 2392 patients in 24 publications (32 studies). The pooled sensitivity, specificity, and AUC values were 0.82, 0.83, and 0.89, respectively. Subgroup analyses showed that the expression of non-coding RNA (miRNA, circRNA, andlncRNA) in the blood circulatory system (including blood, plasma, and serum) of BC was more prone to be detected in TNM stage and subtype of BC group, with a high value of the sensitivity and AUC. Conclusions: The blood circulatory system (including blood, plasma, and serum) of miRNAs, circRNAs, and lncRNAs detection may be effective for diagnosing breast cancer, particularly in TNM stage, subtype of BC (ER/PgR, PR or HER2/c-erbB-2) group of breast cancer. Further studies are needed to identify the value of these non-coding RNAs as novel markers in clinical.