bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatio-temporal evolution characteristics and pattern formation of a gas–liquid interfacial AC current argon discharge plasma with a deionized water electrode
Authors: QAZI Hafiz Imran Ahmad , KHAN Muhammad Ajmal , HUANG Jianjun 
Published: December 2020

Abstract
A discharge ignited by an AC power source in contact with deionized water as one of the electrodes is investigated. Immediately after initiation, the discharge exhibits a unique phenomenon: the gas-phase discharge is extended into the liquid. Later, a cone-like structure is observed at the liquid surface. Synchronous monitoring of current–voltage characteristics and liquid properties versus time suggests that the discharge shapes are functions of the liquid properties. The spatio-temporal profiles indicate the potential effects of water, ambient air impurities, and metastable argon on the discharge chemistry. This becomes more obvious near the liquid surface due to increasing production of various transient reactive species such as ·OH and NO·. Moreover, it is revealed that thermalization of the rotational population distributions of the rotational states

(

N
′

≤
6
,

J
′

≤

13

/
2

)

in the Q
1 branch of the OH

A

Σ

+

2

,

υ
′

=
0
→
X

Π

3
/
2

2

,

υ

″

=
0

band ro-vibrational system is influenced by the humid environment near the liquid surface. In addition, the transient behaviors of instantaneous concentrations of long-lived reactive species (LRS) such as H2O2,

NO

2

−

,

and

NO

3

−

are observed with lengthening the discharge time. The production of multiple transient and LRS proposes AC excited gas–liquid argon discharge as a potential applicant in industrial wastewater cleaning, clinical medicine, and agriculture.
Can the Risk of Severe Depression-Related Outcomes Be Reduced by Tailoring the Antidepressant Therapy to Patient Characteristics?
Authors: Coulombe Janie , Moodie Erica E M , Shortreed Susan M , Renoux Christel 
Published: December 2020

Abstract
Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for patients with unipolar depression, yet there is little guidance on which SSRI provides the most benefit to a patient, based on personal characteristics. In this work, we explore whether an individualized treatment strategy can be used by health-care providers to adapt their prescription pattern to reduce the risk of a severe depression-related outcome (SDO) when choosing between citalopram and fluoxetine, 2 commonly prescribed SSRIs. Our population-based cohort study used data from the Clinical Practice Research Datalink, the Hospital Episode Statistics repository, and the Office for National Statistics database in the United Kingdom to create a cohort of individuals diagnosed with depression who were prescribed citalopram or fluoxetine between April 1998 and December 2017. Patients were followed from treatment initiation until occurrence of the SDO outcome, treatment discontinuation, or end of study. To find an optimal treatment strategy, we used dynamic weighted survival modeling, considering patient features such as age, sex, body mass index, previous psychiatric diagnoses, and medications. Our findings suggest that using patient characteristics to tailor the antidepressant drug therapy is associated with an increase of 4 days in the median time to SDO (95% confidence interval: 2, 10 days).
The Reality of Rural Crime: The unintended consequences of rural policy in the co-production of badger persecution and the illegal taking of deer
Authors: Goodall Orlando 
Published: December 2020

Abstract
Rural policy has produced the unintended consequences of illegal deer taking and the persecution of badgers in the rural West Country of England. This article directs attention towards the mechanisms of social relations between unregulated industry operatives, rural networks and entrepreneurial premises. Accordingly, the offending process is shown to be one of ‘illicit enterprise’, accomplished for instrumental gain through interdependencies between licit and illicit endeavours—practices that emerge synergistically, upon interaction with wider geo-historical conditions. Crucially, illicit activity is shown to be heavily context dependent, contingencies that generate unanticipated outcomes that are peculiar to the tendencies of the South West. Distal conditions are inserted into the explication to posit the antecedent contexts that inadvertently enable the illegal killing of animals.
SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation
Authors: Yasukawa Yoshimi , Hattori Naoko , Iida Naoko , Takeshima Hideyuki , Maeda Masahiro , Kiyono Tohru , Sekine Shigeki , Seto Yasuyuki , Ushijima Toshikazu 
Published: December 2020

Abstract
Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs from gastric cancer and a mechanism for its dysregulation. Expression microarray using eight CAFs and seven non-CAFs (NCAFs) revealed that serum amyloid A1 (SAA1), which encodes an acute phase secreted protein, was second most upregulated in CAFs, following IGF2. Conditioned medium (CM) derived from SAA1-overexpressing NCAFs was shown to increase migration of gastric cancer cells compared with that from control NCAFs, and its tumor-promoting effect was comparable to that of CM from CAFs. In addition, increased migration of cancer cells by CM from CAFs was mostly canceled with CM from CAFs with SAA1 knockdown. Chromatin immunoprecipitation (ChIP)-quantitative PCR showed that CAFs had higher levels of H3K27ac, an active enhancer mark, in the promoter and the two far upstream regions of SAA1 than NCAFs. Also, BET bromodomain inhibitors, JQ1 and mivebresib, decreased SAA1 expression and tumor-promoting effects in CAFs, suggesting SAA1 upregulation by enhancer activation in CAFs. Our present data showed that SAA1 is a candidate therapeutic target from gastric CAFs and indicated that increased enhancer acetylation is important for its overexpression.
Misbalance of thyroid hormones after two weeks of exposure to artificial light at night in Eurasian perchPerca fluviatilis
Authors: Kupprat Franziska , Kloas Werner , Krüger Angela , Schmalsch Claudia , Hölker Franz 
Published: December 2020

AbstractArtificial light at night (ALAN) can affect the physiology and behavior of animals because it alters the natural rhythm of light and darkness. Thyroid hormones (TH) are partially regulated by the light information of photoperiod and are involved in metabolic adjustments to daily and seasonal changes in the environment, such as larval and juvenile development, somatic growth and reproduction. ALAN can change photoperiodic information and might thereby lead to changes in thyroid metabolism, but so far research on this topic is scarce. Therefore, we tested in two different experiments the effects of nocturnal illumination at a wide range of light intensities on TH in plasma of Eurasian perch (Perca fluviatilis). Total 3,3′,5-triiodo-L-thyronine (T3) was significantly affected by ALAN and reduced at the highest tested intensity of 100 lx after only two weeks of exposure. Although total L-thyroxine (T4) was not significantly affected, the ratio of T3 to T4 tended to slightly decrease at 100 lx. In a second low-light experiment ALAN did not have clear effects on T3, T4 or the ratio of T3 to T4 at intensities between 0.01 lx and 1 lx. The results show first signs of endocrine disruption in thyroid metabolism after a relatively short ALAN exposure of two weeks under high-intensity streetlight conditions. Misbalanced thyroidal status can have serious implications for metabolic rates as well as developmental and reproductive processes.
Feather corticosterone does not correlate with environmental stressors or body condition in an endangered waterbird
Authors: Gormally Brenna M G , van Rees Charles B , Bowers Emily , Reed J Michael , Romero L Michael 
Published: December 2020

Abstract
Physiological metrics are becoming popular tools for assessing individual condition and population health to inform wildlife management and conservation decisions. Corticosterone assays can provide information on how animals cope with individual and habitat-level stressors, and the recent development of feather assays is an exciting innovation that could yield important insights for conservation of wild birds. Due to the widespread enthusiasm for feather corticosterone as a potential bioindicator, studies are needed to assess the ability of this technique to detect meaningful differences in physiological stress across a variety of stressor types and intensities. We examined feather corticosterone from 144 individuals among the 13 known breeding populations of Hawaiian gallinule (Gallinula galeata sandvicensis), an endangered waterbird, on the island of O‘ahu. These ecologically independent subpopulations are known to have low genetic connectivity and movement rates and differ largely across a number of important conditions, including level of predator management, human disturbance, proximity to urban development and conspecific population density. This system is well suited for assessing the performance of feather corticosterone as a bioindicator of different known habitat-level threats common to this and many other conservation-reliant species. We found no statistically significant relationship between feather corticosterone and level of predator control, level of human disturbance, gallinule population density, percent urban cover or body condition across all sites despite the substantial difference in stressor magnitude in our dataset. We did find that gallinules in habitats with larger population densities were in worse body condition. These findings suggest that feather corticosterone is not a consistent indicator of anthropogenic impacts on populations. Furthermore, they suggest that feather corticosterone may be a poor bioindicator of known habitat-level threats for Hawaiian gallinules and that it should be used with caution in other avian taxa of conservation concern.
Comparison of bicuspid and tricuspid aortic valve repair
Authors: Gocoł Radosław , Bis Jarosław , Malinowski Marcin , Ciosek Joanna , Hudziak Damian , Morkisz Łukasz , Jasiński Marek , Deja Marek A 
Published: December 2020

Abstract

OBJECTIVES
The aim of this study was to compare the outcomes of tricuspid aortic valve (TAV) and bicuspid aortic valve (BAV) repair.

METHODS
We assessed mortality, freedom from reoperation and the rate of aortic valve regurgitation recurrence. Mortality in both groups was compared with expected survival, and risk factors for reoperation were identified.

RESULTS
From January 2010 to April 2020, a total of 368 elective aortic valve repair procedures were performed, including 223 (60.6%) in patients with TAV. The perioperative mortality was 0.7% in the BAV group and 3.6% in the TAV group (P = 0.079). Estimated survival at 5 years in the BAV versus TAV group was 97 ± 3% vs 80 ± 6%, respectively (P &lt; 0.001). Freedom from reoperation at 5 years in the TAV versus BAV group was 96 ± 3% vs 93 ± 4%, respectively (P = 0.28). Grade 2 or more aortic valve regurgitation was noted in 9.9% of BAV patients and 11% of TAV patients (P = 0.66). Reoperation was predicted by cusp perforation [hazard ratio 15.86 (4.44–56.61); P &lt; 0.001], the use of pericardial patch [hazard ratio 8.58 (1.96–37.53); P = 0.004] and aortic valve annulus diameter &gt;27.5 mm [hazard ratio 3.07 (0.99–9.58); P = 0.053].

CONCLUSIONS
BAV repair is as durable as TAV repair. BAV is not a predictor of a higher rate of reoperations. BAV repair yields survival comparable to expected. Cusp perforation, aortic valve annulus diameter &gt;27.5 mm and the use of pericardial patch adversely impact long-term outcome of aortic valve repair.
Objective method to evaluate the competency of residents in cardiac surgery
Authors: Badreldin Akmal M A , Muehle Anja , Misic Jovan , Tvildiani Tamari , Duerr Georg Daniel , Paulini-Heine Beate , Peivandi Ali Asghar 
Published: December 2020

ABSTRACT

OBJECTIVES
Cardiac surgery training has become more challenging as patients and their diagnoses become more complex. Our goal was to develop a multicategorical assessment model for evaluating residents in cardiac surgery. This model is intended to ensure goal-directed progress in their training as well as to recognize and support their surgical talents.

METHODS
We developed a new questionnaire in a multistage, 3-round process based on the Delphi method ‘estimate-talk-estimate’, using 55 competencies, including 38 general and 17 domain-specific competencies. Each competency is evaluated with 1 or more questions, to which 1 (not competent) to 6 (very competent) points can be chosen as an answer.

RESULTS
The resulting model achieved 2 main goals: first, presenting a well-defined competency list for cardiac surgical training and second, providing an objective and realistic evaluation of trainees’ abilities. Residents were assessed by all trainers to achieve a high level of objectivity.

CONCLUSIONS
This evaluation model is highly objective, because residents are evaluated by multiple trainers. It allows individual support and enables better transparency in residency training. Talents and skills are evaluated, recognized and adopted as a base for individual feedback and personalized training programmes.
Proof of the triple prerequisite conditions which are essential for carbapenem resistance development in Klebsiella pneumoniae by using radiation-mediated mutagenesis
Authors: Pinto Naina Adren , D'Souza Roshan , Nguyen Le Phuong , Vu Thao Nguyen , Yong Dongeun 
Published: December 2020

ABSTRACT
Evolution of multi-drug resistant bacteria has led to worldwide research to better understand the various resistance mechanisms in these strains. Every year, novel information on carbapenem resistance and its mechanisms is being discovered. In this study, radiation-mediated mutagenesis was used to transform a carbapenem-resistant Klebsiella pneumoniae strain to a carbapenem-susceptible bacterium. Through this process, we proved three conditions of loss of the OmpK35 and the OmpK36 genes and acquisition of blaCMY-10 worked together to produce carbapenem resistance in K. pneumoniae. Loss of only one of the porins did not evoke carbapenem resistance. This is the first report on the essential contribution of these three components of carbapenem resistance in K. pneumoniae.
Stability of discrete schemes of Biot’s poroelastic equations
Authors: Alkhimenkov Y , Khakimova L , Podladchikov YY 
Published: December 2020

SUMMARYThe efficient and accurate numerical modelling of Biot’s equations of poroelasticity requires the knowledge of the exact stability conditions for a given set of input parameters. Up to now, a numerical stability analysis of the discretized elastodynamic Biot’s equations has been performed only for a few numerical schemes. We perform the von Neumann stability analysis of the discretized Biot’s equations. We use an explicit scheme for the wave propagation and different implicit and explicit schemes for Darcy’s flux. We derive the exact stability conditions for all the considered schemes. The obtained stability conditions for the discretized Biot’s equations were verified numerically in one-, two- and three-dimensions. Additionally, we present von Neumann stability analysis of the discretized linear damped wave equation considering different implicit and explicit schemes. We provide both the Matlab and symbolic Maple routines for the full reproducibility of the presented results. The routines can be used to obtain exact stability conditions for any given set of input material and numerical parameters.
Quantitative assessment of successive carbohydrate additions to the clusteredO-glycosylation sites of IgA1 by glycosyltransferases
Authors: Stewart Tyler J , Takahashi Kazuo , Xu Nuo , Prakash Amol , Brown Rhubell , Raska Milan , Renfrow Matthew B , Novak Jan 
Published: December 2020

AbstractMucin-type O-glycosylation occurs on many proteins that transit the Golgi apparatus. These glycans impact structure and function of many proteins and have important roles in cellular biosynthetic processes, signaling and differentiation. Although recent technological advances have enhanced our ability to profile glycosylation of glycoproteins, limitations in the understanding of the biosynthesis of these glycan structures remain. Some of these limitations stem from the difficulty to track the biosynthetic process of mucin-type O-glycosylation, especially when glycans occur in dense clusters in repeat regions of proteins, such as the mucins or immunoglobulin A1 (IgA1). Here, we describe a series of nano-liquid chromatography (LC)–mass spectrometry (MS) analyses that demonstrate the range of glycosyltransferase enzymatic activities involved in the biosynthesis of clustered O-glycans on IgA1. By utilizing nano-LC–MS relative quantitation of in vitro reaction products, our results provide unique insights into the biosynthesis of clustered IgA1 O-glycans. We have developed a workflow to determine glycoform-specific apparent rates of a human UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltrasnfersase (GalNAc-T EC 2.4.1.41) and demonstrated how pre-existing glycans affect subsequent activity of glycosyltransferases, such as core 1 galactosyltransferase and α2,3- and α2,6-specific sialyltransferases, in successive additions in the biosynthesis of clustered O-glycans. In the context of IgA1, these results have potential to provide insight into the molecular mechanisms implicated in the pathogenesis of IgA nephropathy, an autoimmune renal disease involving aberrant IgA1 O-glycosylation. In a broader sense, these methods and workflows are applicable to the studies of the concerted and competing functions of other glycosyltransferases that initiate and extend mucin-type core 1 clustered O-glycosylation.
Barriers and facilitators to knowledge translation activities within academic institutions in low- and middle-income countries
Authors: Kalbarczyk Anna , Rodriguez Daniela C , Mahendradhata Yodi , Sarker Malabika , Seme Assefa , Majumdar Piyusha , Akinyemi Oluwaseun O , Kayembe Patrick , Alonge Olakunle O 
Published: December 2020

Abstract
The barriers and facilitators of conducting knowledge translation (KT) activities are well-established but less is known about the institutional forces that drive these barriers, particularly in low resource settings. Understanding organizational readiness has been used to assess and address such barriers but the employment of readiness assessments has largely been done in high-income countries. We conducted a qualitative study to describe the institutional needs and barriers in KT specific to academic institutions in low- and middle-income countries. We conducted a review of the grey and published literature to identify country health priorities and established barriers and facilitators for KT. Key-informant interviews (KII) were conducted to elicit perceptions of institutional readiness to conduct KT, including experiences with KT, and views on motivation and capacity building. Participants included representatives from academic institutions and Ministries of Health in six countries (Bangladesh, Democratic Republic of the Congo, Ethiopia, India, Indonesia, Nigeria). We conducted 18 KIIs, 11 with members of academic institutions and 7 with policymakers. KIIs were analysed using a deductive and inductive coding approach. Our findings support many well-documented barriers including lack of time, skills and institutional support to conduct KT. Three additional institutional drivers emerged around soft skills and the complexity of the policy process, alignment of incentives and institutional missions, and the role of networks. Participants reflected on often-lacking soft-skills needed by researchers to engage policy makers. Continuous engagement was viewed as a challenge given competing demands for time (both researchers and policy makers) and lack of institutional incentives to conduct KT. Strong networks, both within the institution and between institutions, were described as important for conducting KT but difficult to establish and maintain. Attention to the cross-cutting themes representing barriers and facilitators for both individuals and institutions can inform the development of capacity building strategies that meet readiness needs.
Reducing health inequities facing boys and young men of colour in the United States
Authors: Smith James A , Watkins Daphne C , Griffith Derek M 
Published: December 2020

Summary
Health promotion research and practice consistently reveals that people of colour in the USA face multiple structural and systemic health and social inequities as a direct consequence of racism and discrimination. Recent scholarship on equity and men’s health has highlighted the importance of gender—specifically concepts relating to masculinities and manhood—to better understand the inequities experienced by men of colour. A sharper focus on the intersection between race, gender and life stage has also emphasized the importance of early intervention when addressing inequities experienced by boys and young men of colour (BYMOC). This has led to an expansion of health promotion interventions targeting BYMOC across the USA over the past decade. Many of these health promotion strategies have attempted to reduce inequities through action on the social determinants of health, particularly those that intersect with education and justice systems. Reflecting on these developments, this commentary aims to discuss the challenges and opportunities faced by the health promotion community when attempting to reduce health and social inequities experienced by BYMOC. In doing so, the solutions we identify include: strengthening the evidence base about effective health promotion interventions; reducing system fragmentation; promoting connectivity through networks, alliances and partnerships; reducing tensions between collaboration and competition; changing the narrative associated with BYMOC; acknowledging both inclusiveness and diversity; addressing racism and intergenerational trauma; and committing to a national boys and men’s health policy. We encourage health promotion researchers, practitioners and policy-makers to adopt these solutions for the benefit of BYMOC in the USA.
Contested Indigeneity and Traditionality in Environmental Litigation: The Politics of Expertise in Regional Human Rights Courts
Authors: Petersmann Marie-Catherine 
Published: December 2020

ABSTRACT
In times when intricate concerns for social and ecological justice are becoming ever more prominent in global environmental discourses, conflicts between minorities’ rights and environmental policies present delicate trade-offs that demand ingenious balancing by regional human rights courts. Such conflicts tend to boil down to oppositions between ‘indigenous’ or ‘traditional’ practices set against ‘modern’ ideals, thereby displaying and performing important normative, epistemic and political implications. To legitimise and strengthen their cases, parties resort to expert interventions. While the involvement of experts speaking on behalf of minorities can bolster the communities’ legal protection, the shared assumptions, rhetorical style and professional sensibility of intervening experts can trigger unintended consequences for the identity and (self-)perception of the peoples they represent. The case-law analysis presented here instantiates how networks of experts with shared institutional ties intervene before courts, use specific discursive strategies to further their representatives’ claims and reinforce the normative salience of their interventions through cross-jurisdictional and cross-cultural referencing. Drawing on insights from discourse analysis, (legal) anthropology and cultural geography, the article develops a critique of the politics of expert-based approaches to conflict management in regional human rights settings.