bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative Wireline Mast Design Improves Safety and Performance for Standalone Operations
Authors: MacDonald Alistair , Thomassen Torstein 
Published: March 2020

Abstract
For standalone wireline well interventions on offshore platforms, a number of challenges are faced. As a result, a world first technology in the form of a combined wireline mast and tower system has been developed and successfully implemented to address these safety and operational issues. To date, there has been recognition for the successful implementation of this technology in the UK, winning The ICoTA LEA Award for Innovation and Technology for 2019, judged annually by representatives from ICoTA Europe, Oil & Gas UK and SPE Aberdeen and awarded by the ICoTA Europe Chapter at the European Well Intervention Conference and as a finalist at the 2019 Oil and Gas UK Offshore Safety Awards for Innovation in Safety.
Shell UK worked with DWELLOP to successfully implement their innovative design on the Brent Charlie platform as part of its abandonment campaign. It is shipped as a self-contained single item and secured onto an Adapter Hatch which acts as an interface between offshore installation deck and mast. The mast is then hydraulically erected and its telescopic sections locked in place to the desired height, allowing well intervention work to commence. This addresses key challenges faced on offshore platforms, namely a large quantity of crane lifts, inefficient rigging up / down and deck management as the footprint of conventional masts is significant, requiring high scaffolding towers and guy wires spanning across the platform deck.
This paper gives an overview of the value and challenges of standalone wireline operations, with particular focus on the application towards well abandonment operations on Shell's Brent Charlie platform, offshore UK. A technical breakdown will then be given of the new wireline mast and results from the first campaign presented to illustrate the clear step change in safety and performance as a result of this new technology.
Rig-Less Coiled Tubing Intervention for Production Optimisation
Authors: Thevarayan Vidhya , Greig Neil 
Published: March 2020

Abstract
In May 2019, Shell UK E&P contacted the Helix Well Ops Light Well Intervention Vessel; Well Enhancer to conduct a Coiled Tubing Intervention in a horizontal well using their riser system for production optimisation. This CT system had been in active use since 2016, however, based on operational lessons learnt, it underwent a series of upgrades and improvements to create a more efficient and reliable means of Coiled Tubing Deployment. The intervention carried out in May was the first since the upgrades were completed.
The technical objectives for the intervention were:
Drift and clean-up using a motorised venturi to 14,700 ft Perform shut-in and flowing PLT log across 4,000ft of perforations Re- perforate 1,000ft of reservoir section
The operations were completed on time and on budget.
This technology application has now been proven and enables Coiled Tubing opportunities, previously considered uneconomical or technically unachievable unless using a rig, to be sanctioned.
Multilateral Reentry System for Well Surveillance: Design, Implementation and Summary of 40 Jobs Performed in Fields
Authors: Saeed Abubaker , Yakovlev Timofey , Sagr Hani , Harthi Sultan 
Published: March 2020

Abstract
Multilateral wells are a popular choice for fields where maximum fixed asset utilization is required. Although Drilling and Intervention (Stimulation) techniques for such wells are mature and reliable, reservoir surveillance required novel method for lateral access. Such technology was developed and used in more than 40 wells in Middle East. Summary of experience, description of tools and methods, lessons learned and vision for further development will be described in this work.
In order to be useful for lateral reentry and logging, intervention system should comply with following minimum requirements: Be compatible with logging tools and systems provided by various Service companies and with various conveyance methods.Operate with logging systems, not equipped with wired through capability.Be of slim design so it can be used in variety of completions.Be equipped with diagnostics systems to detect laterals and confirm successful entry.
All these requirements were implemented in new Multilateral reentry system. Once in field, system was proven reliable and useful for logging intervention in multilateral wells in various operating conditions.
Multilateral reentry system, consisting of motorized bend sub, wireless communication bridge and diagnostic section was designed, tested and further deployed in field. Within 40 jobs performed it was operating in variety of environments (onshore, offshore); open hole and cased hole completions; was run in oil, gas and water wells, in conjunction with most of commonly used logging systems. Although during most of jobs conveyance was performed using electric line Coiled Tubing, some of wells were accessed on wireline using Well Tractor technology. The system was proven reliable and practical experience was gathered for successful operation of this and any other multilateral reentry system to be designed in future. Application of this system allowed to receive important data needed for fields development and allowed optimization of completion systems in some cases. Although overall application of multilateral intervention system was a success, improvement areas were identified in order to increase operational portfolio; and will be presented in this paper. Recommendations of intervention friendly well design will be shared as well.
As unique experience of running Multilateral reentry system for logging purpose is described here, with practical recommendations on well construction, surveillance planning, execution and evaluation, this paper will be interesting to wide category of practicing engineers of various specialties.
High Strength Coiled Tubing - How is Fatigue Life Affected by Slip Damage?
Authors: Sherman Scott , Majko Sean M , Otto Jeffrey 
Published: March 2020

Abstract
Since the inception of quench and tempered coiled tubing, a question has come up numerous times. Do we need specialized handling equipment for this stronger and correspondingly harder pipe? Harder coiled tubing implies that blow out preventers (BOPs) must have sufficiently hard slips to grip the pipe as well as sufficiently hard shear blades to cut the pipe. Testing has shown that in most cases, existing BOP components have been sufficient to grip and cut quench and tempered coiled tubing.
Once BOP slips have been set on the harder pipe and a real world ‘pipe heavy’ load applied, how significantly is the fatigue life of quench and tempered coiled tubing affected?
This paper will highlight the findings of some recent testing of quench and tempered coiled tubing and will compare the results to conventional coiled tubing. In this study, 2-3/8″ coiled tubing was subjected to a tensile load of 44,500 daN (100,000 lbs) while being held in BOP slips. The coiled tubing was then tested on a bend fatigue machine with the slip marks at the ‘sweet spot’ to determine the number of cycles to failure. Four grades of quenched and tempered coil tubing were tested as well as a baseline sample of 100 grade coiled tubing. The aim of this paper is to demonstrate that modern BOPs can grip high strength coiled tubing and point out the effect on fatigue life of the resulting slip marks.
Supporting women who develop poor postnatal mental health: What support do fathers receive to support their partner and their own mental health?
Authors: Author) Andrew Mayers(New Corresponding , Author) Sarah Hambidge(Former Corresponding , Bryant Olivia , Arden-Close Emily 
Published: March 2020

Abstract

Recent interest has been shown regarding support provided for poor maternal postnatal mental health. Fathers appear to play an important role within this support but many feel alienated within maternal services. The current qualitative study aimed to investigate fathers’ experience of support provided to fathers, to help support their partner should she experience poor postnatal mental health. Twenty-five fathers participated in an online questionnaire regarding their experience of their partner’s poor postnatal mental health and the support provided to fathers to help her. Thematic analysis revealed three main themes: ‘Support received to help support their partner’, ‘Support fathers wanted that was not received’ and ‘Father’s mental health’. The results highlight an overall lack of support for many fathers, despite many wanting support on how to help their partner, information on their own mental health and the services available. Fathers specifically wanted healthcare professionals to sign-post them to someone they can talk to for emotional support, and to be taught coping strategies which would help them to support both their partner and baby. The findings from this study suggest that health professionals and perinatal mental health services need a better understanding about what resources fathers need to support the mental health of themselves and their partner.
Improved survival rate and functional recovery of TKA in cementless fixation compared with cemented component: a systematic review and meta-analysis
Authors: Liu Yuan , Zeng Yi , Wu Yuangang , Li Mingyang , Xie Huiqi , Shen Bin 
Published: March 2020

Abstract
Background: Whether the cement could be given up in total knee arthroplasty (TKA) was still in controversy. We perform this meta-analysis to compare the rate of revision and functional recovery between two kinds of fixation in TKA. Methods: Randomized controlled trials (RCTs), prospective/retrospective observational studies from PubMed (on 2019 Sep), EMBASE (on 2019 Sep), and the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science (on 2019 Sep) were searched. Continuous outcomes were presented as mean difference or standard mean difference with 95% CI and discontinuous outcomes were reported as relative risk (RR) with 95% CI. Random-effects or fixed-effects model was conducted to analyze the extracted data. The PRISMA guidelines and Cochrane Handbook were adopted to assess the quality of the results reported in included studies to ensure that the results of our meta-analysis were reliable and veritable. The continuous and dichotomous outcome were collected in a standard form, and the data were analysed by using Review Manager 5.3 software. Finally, the results were presented in the Forest plots. The rate of revision and reasons caused revision was the primary outcome of our study.Results: Twenty-six studies involving 2369 patients in cementless TKA and 2654 patients in cemented TKA were finally included in our meta-analysis. 26 studies were divided into three subgroups according to the length of follow-up. The studies in the first subgroup followed less than 5.5 years, the second followed less than 10.5 years, and the third followed more than 10.5 years. Cementless fixation significantly decreased the rate of aseptic loosing (p=0.0002) and revision (p=0.0002) in the first subgroup. Other reasons such as periprosthetic joint infection (PJI), instability and polyethylene wear were not significantly different between two groups. Significantly better functional recovery was got in cementless TKA in terms of Knee Society Function Score (p=0.01) when followed longer than 8.5 years. Significantly less patients in cementless group require manipulation under anesthesia (p=0.02) when duration was longer than 5.5 years. However, there was no significant difference regarding the rate of complication between two kinds of fixation in TKA.Conclusion: Not only the rate of aseptic loosing was decreased, rate of revision was also significantly decreased in cementless TKA within 5.5 years. In addition, the cementless TKA seemed performed better in postoperative functional recovery when had a long-term follow-up. However, the rate of complication was not significantly different in two kinds of fixation in TKA.
Comparison of the effect of exercise on stable surface versus unstable surface on cross section area of lumbar multifidus muscle and thickness of abdominal muscle in patients with chronic low back pain
Authors: Emami Mozhgan , Emami Farahnaz , Nezhad Farahnaz Ghafari , Taghizadeh Shohreh 
Published: March 2020

Abstract
Objective The aims of this study were, comparison the effects of core stability exercises performed on a stable or unstable surface on the thickness of abdominal and lumbar multifidus muscle in patients with non-specific chronic low back pain. Method Thirty-four patients were randomly assigned to an unstable or stable surface group (n = 17 each). Both groups did five core stability exercises for 6 weeks (three times per week). the thickness of the core muscle was evaluated pre and post-treatment. Results After 6 weeks of training, in both groups, all variables improve. internal oblique muscle thickness and transversus abdominis thickness in the unstable surface group improved significantly more than those in the stable surface group (p <0.05). Conclusion Our findings indicate exercise on an unstable surface more effective in improving the core muscle thickness relative to stable surface in patients with non-specific chronic low back pain. However, extra studies are required to support our findings.
Methanogenic Granules Are Replicated, Whole Microbial Communities With Reproducible Responses To Environmental Cues
Authors: Trego Anna Christine , O'Sullivan Sarah , Mills Simon , Porca Estefania , Quince Christopher , Ijaz Umer Zeeshan , Collins Gavin 
Published: March 2020

Abstract
Background In this study, individual anaerobic granular biofilms were used as true community replicates to assess whole-microbial-community responses to environmental cues. The aggregates originated from three different biomass sources, i.e. three different engineered biological wastewater treatment systems, were each size-separated into three fractions – small, medium and large – and characterised according to organic matter concentrations and rates of methanogenic activity. Differences in the microbial community structure of each size fraction from each source were determined using 16S rRNA gene sequencing. Subsequently, single granules from the large size fraction of one of the sources were separately subjected controlled environmental cues in novel micro batch reactors (mBRs). Results Organic content, methanogenic activity, and microbial community were significantly different between the three size fractions, with diversity trajectories replicated across the three sludge sources – indicating a potential development model as granules age. Individual large granules from one of these sources were statistically identical with respect to the structure of the active community based on cDNA analysis. It was observed that the active microbial community of individual granules, at the depth of 16S rRNA sequencing, produced reproducible responses to environmental conditions. While each condition resulted in the up-regulation of particular OTUs and clades, the core microbiome, consisting of many fermentative bacteria along with methanogenic archaea, namely, Methanosarcina and Methanobacterium , persisted. Conclusions At this level, single anaerobic granules can be considered highly-replicated whole-ecosystems, opening the door to high-throughput studies in Microbial Ecology.
MicroRNA-155-5p promotes tumor progression and contributes paclitaxel resistance to chemotherapy via TP53INP1 in human Breast Cancer
Authors: Li Yu , Zhang Lingyu , Dong Zhengyuan , Xu Henan , Yan Lei , Yang Shuo , Chen Tiantian , Chen Sulian , Wang Wenrui , Yang Qingling , Chen Changjie 
Published: March 2020

Abstract
Background MicroRNAs (miRNAs) are a class of small, non-coding RNAs that functioned by targeting specific mRNA. Many studies have reported that, miRNAs play a vital role in cancer progression, they can exert their functions as oncogenes or cancer suppressors. As suggested in previous report, miR-155-5p is up-regulated in breast cancer. Results Here, we found that miR-155-5p promoted cell proliferation and inhibited cell apoptosis in MCF-7. In addition, these effects were reversed when high levels of miR-155-5p were suppressed in MCF7/PR. We determined that TP53INP1 served as a direct target of miR-155-5p through bioinformatic and luciferase assay. These findings confirmed that miR-155-5p was a tumorigenic factor that acted by targeting TP53INP1 and promoted tumor progression and contributed paclitaxel resistance to chemotherapy. Conclusions These results contribute to our understanding of the molecular mechanism underlying breast cancer progression and resistance to chemotherapy.
Prevalence and risk factors for death in sepsis- associated brain dysfunction: a retrospective study from ICU admissions
Authors: Tong Dao-Ming , Zhou Ye-Ting , Wang Shao-Dan 
Published: March 2020

Abstract
Background: The prevalence of sepsis-associated brain dysfunction (SABD) in ICU patients with critically ill remains unknown. We are to assess whether the prevalence of sepsis in ICU would present a high prevalent life- threatening SABD. Methods: We enrolled acute critically ill adults patients from ICU (from January 1, 2015, to January 1, 2017). All patients were selected from onset to ICU ≤3 hours and followed up to 30 day for sepsis patients who were treated in initial 48 hours or more in ICU. The predictors and risk of death of SABD was analyzed by multivariate models. Results: Of the 1349 ICU patients with acute critically ill, 748 were enrolled. Among these, the prevalence of sepsis was 48.4% (362/748). The prevalence of SABD accounted for 97.2% of sepsis (352/362), with fatality at initial 30 days was 73.6%. We found that the strong clinical predictors or markers for SABD were a SIRS ≥2 (OR, 3.2; 95% CI, 1.7-6.1), SOFA score ≥6 (OR, 3.0; 95% CI, 2.6-3.5), and qSOFA score ≥2 (OR, 0.34; 95% CI, 0.16-0.58). Cox logistic adjusted analysis revealed that lower mean arterial pressure (MAP) (OR, 1.5; 95% CI, 1.0-1.7)，higher SOFA score (OR, 1.8; 95% CI, 1.1- 1.9), and unused a rapid antibiotics treatment in initial 3 hours (OR, 0.7; 95% CI, 0.5-0.9) were the predictors of the risk of death among ICU patients with SABD. Conclusions: SABD is a leading life-threatening organ dysfunction following critically ill in ICU, with an high fatality. The predictors for worse survival SABD were related to the lower MAP, higher SOFA scores, and unused a rapid antibiotic treatment within initial 3 hours.
Technology, TFPG and Employment: A Panel Data Analysis
Authors: Malik Sameer , Mitra Arup 
Published: March 2020

Abstract
This paper based on the United Nations Industrial Development Organization (UNIDO) panel data set makes an attempt to estimate total factor productivity growth across countries. Productivity convergence over time is evident when countries are divided across regions which could be attributed to a greater degree of association of countries in a given region pursuing joint efforts for infrastructural development, ICT coverage and advancement, trade negotiations, technology acquisition and innovation, and inflow of FDI. In terms of efficiency estimates for select years most of the countries are seen to be operating much below the frontier. This is indicative of the fact that countries are keen to pursue resource-driven growth in an attempt to maximize it. Based on the inter-temporal data we observed that a number of countries registered either a negative or a positive but low correlation between labour productivity growth and TFPG. Evidently, countries are engaged in greater mechanization which may be raising labour productivity without ushering in much success in terms of TFPG. From panel data regression the impact of technology perceived in terms of TFPG, on employment is seen to be negligible though it is important to note that none of the groups, income or region wise, recorded a statistically significant negative effect except the LDC, while the significant cases (howsoever scanty) reveal a positive association. Appropriate incentives may motivate firms to experience technological progress and employment growth both.
Prophylactic role of Lactobacillus Paracasei exopolysaccharides on colon cancer cells through apoptosis not ferroptosis
Authors: Saadat Yalda Rahbar , Gargari Bahram Pourghassem , Shahabi Arman , Nami Yousef , Khosroushahi Ahmad Yari 
Published: March 2020

Abstract
Nowadays despite conventional methods in colon cancer treatment, targeting vital molecular pathways and induction of various forms of cell death by safe probiotic components like exopolysaccharides (EPSs) are of great importance and are considered as potential therapeutic agents. This study aimed to investigate the inhibitory effect of the EPS of L. paracasei on different colon cancer cell lines (SW-480, HT-29, and HCT-116). For this purpose, several cellular and molecular experiments including MTS assay, DAPI staining, Annexin V/PI assay, quantitative real-time PCR (qPCR) and some important ferroptosis-related assays were performed. Based on the findings, L. paracasei EPS can induce apoptosis confirmed by all apoptosis-related assays and could not act through ferroptosis pathways. L. paracasei EPS could hinder the Akt1, mTOR, and Jak-1 mRNAs, and induces apoptosis through down-regulation of the anti-apoptotic gene (Bcl-2), up-regulation of pro-apoptotic genes (BAX, caspase-3, 8). The exploited EPS of an indigenous probiotic strain with anticancer potential with low/insignificant cytotoxicity to normal cells is proposed for future applications in molecular-targeted therapy of colon cancer treatment. Furthermore, in vivo and clinical trials should be performed to evaluate the applicability of this component besides conventional methods to increase the survival rate of colon cancer patients.