bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using an ultraviolet cabinet improves compliance with the World Health Organization’s hand hygiene recommendations by undergraduate medical students: a randomized controlled trial
Authors: Dray Sandrine , Lehingue Samuel , Valera Sabine , Nouguier Philippe , Boussen Michel Salah , Daviet Florence , Bastian Delphine , Pilarczik Estelle , Jousset Isabelle , Le Floch Sébastien , Grech Georgette , Leonetti Georges , Papazian Laurent , Cassir Nadim , Forel Jean-Marie 
Published: September 2020

Abstract
Background
Appropriate hand hygiene (HH) is key to reducing healthcare-acquired infections. The World Health Organization (WHO) recommends education and training to improve HH knowledge and compliance. Physicians are ranked among the worst of all healthcare workers for compliant handrubbing with its origin probably being the failure to learn this essential behavior during undergraduate medical studies. This study evaluated if the use of Ultraviolet-cabinets (UVc) for fluorescent-alcohol-based handrubs (AHR) during an undergraduate medical student training improved the compliance rate to the WHO hand hygiene recommendations (completeness of AHR application and HH opportunities).

Methods
This randomized trial compared a HH training with personal feedback (using UVc) to a control group. The first year, the students (2nd degree) were convened by groups (clusters) of 6–9 for a demonstration of the correct execution of WHO procedure. Randomization by cluster was done prior HH training. In the control group, the students hand rubbed under visual supervision of a tutor. In the intervention group after the same visual supervision, completeness of fluorescent-AHR hand application was recorded under UVc and was shown to the student. The intervention group had free access to the UVc until complete application. HH practices were included in simulation sessions for the both groups. One year after (3rd degree), all the students were asked to hand rub with fluorescent-AHR. A tutor (blinded to the study group) assessed the completeness of hand application under UVc and the compliance with the WHO opportunities. Complete application of AHR was defined as fluorescence for all the surfaces of hands and wrists.

Results
242 students participated (140 in the intervention group and 102 in the control group). One year after the initial training, the rate of complete application of AHR was doubled in the intervention group (60.0% vs. 30.4%, p < 0.001). In a multivariate analysis which included gender, additional HH or UVc training, surgical traineeship and regular use of AHR, the hazard ratio for the intervention was 3.84 (95%CI: 2.09–7.06). The compliance with the HH WHO’s opportunities was increased in the intervention group (58.1% vs. 42.4%, p < 0.018).

Conclusion
Using UVc for undergraduate medical students education to hand hygiene improves their technique and compliance with WHO recommendations.
Frontiers in the COVID-19 vaccines development
Authors: Haq Ehtisham Ul , Yu Jifeng , Guo Jiancheng 
Published: September 2020

AbstractNovel corona virus caused pneumonia first reported in December, 2019 in Wuhan, China was later named COVID-19. Due to its special pathogenicity, COVID-19 transmitted with high speed beyond borders and has significantly affected normal life. Currently, no specific drugs, treatment or vaccines are available. Vaccine development for COVID-19 is a highly complex process involving viral genomic studies, identification of target for vaccine, vaccine design, manufacturing, storage and distribution, preclinical and clinical safety and efficacy studies. The high levels of efforts and global collaboration at this scale is unprecedented. The World Health Organization (WHO) has documented 160 different COVID-19 vaccine candidates as of July 13, 2020 with 26 currently on clinical evaluation while 137 vaccines on preclinical evaluation. COVID-19 vaccine efforts mark the first use of mRNA-type vaccines ever evaluated. Numerous research organizations have successfully initiated clinical evaluation of COVID-19 vaccines. This review aims to summarize the advances and challenges for COVID-19 vaccines development.
Intravenous calcium as a pressor in a swine model of hypoxic pseudo-pulseless electrical mechanical activity—a preliminary report
Authors: Lindqwister Alexander L. , Lampe Joshua W. , Gould Jeffrey R. , Kaufman Christopher L. , Moodie Karen L. , Paradis Norman A. 
Published: September 2020

Abstract
Background
Pseudo-pulseless electrical activity (pseudo-PEA) is a lifeless form of profound cardiac shock characterized by measurable cardiac mechanical activity without clinically detectable pulses. Pseudo-PEA may constitute up to 40% of reported cases of cardiac arrest. Resuscitation from pseudo-PEA is often associated with hypotension refractory to catecholamine pressors. We hypothesized that this post-resuscitation state may be associated with hypocalcemic hypotension responsive to intravenous calcium.

Methods
Using pre-existing data from our hypoxic swine pseudo-PEA model, we measured blood pressure, hemodynamics, and electrolytes. Physiological data were analyzed on a heartbeat by heartbeat basis. The midpoint of the calcium response was defined using change of curvature feature detection. Hemodynamic parameters were shifted such that the value at the midpoint was equal to zero.

Results
In 9 animals with refractory hypotension, we administered 37 boluses of intravenous calcium in the dosage range of 5-20 mg. Comparisons were made between the average values in the time period 40-37 s before the midpoint and 35-40 s after the midpoint. Of the 37 administered boluses, 34 manifested a change in the blood pressure, with mean aortic pressure, systolic and diastolic pressures all increasing post bolus administration.

Conclusions
Administration of intravenous calcium may be associated with a pressor-like response in refractory hypotension after resuscitation from pseudo-PEA. Relative ionized hypocalcemia may cause hypotension after resuscitation from pseudo-PEA. Therapy with intravenous calcium should be further investigated in this setting.
Impact of gasoline fuel emissions on Rhizopus stolonifer (Ehrenb.) Vuill. and Fusarium oxysporum (Schlecht.)
Authors: Balogun Kayode Peter , Aborisade Abiola Titilola , Oladele Oluwole Olakunle 
Published: September 2020

Abstract
Background
Alteration in the normal composition of gasses in the atmosphere referred to as air pollution can occur as a result of different processes, including emissions from vehicles and power generators. Gasses affect living things directly and indirectly by playing roles in respiration, membrane function, synthesis, and growth. The gasses contained in fumes emitted from vehicles and generators may likely have effect on microorganisms in the environment including microfungi. Two microfungi were selected to study the effect of generator emissions on their growth.

Results
The gaseous emissions from power generators fueled by gasoline caused reduction in spore germination and germ tube lengths of R. stolonifer and F. oxysporum. For the former, spore germination decreased with length of exposure after an initial increase by ~ 100%. The fungus exhibited a single major germination peak at 10 min and a minor one at 30–35 min exposures. Germ tube length of the fungus also decreased with increased exposure. F. oxysporum too showed reduced spore germination and germ tube length with exposure but the fungus seemed to adjust better to the unfavorable environment created by emitted gasses showing multiple peaks of reduced heights as time progressed, though another rise that could reach a peak appeared at the 45-min maximum exposure for germ tube length. The peaks were however more broad for spore germination experiments indicating more stability in adjustment than observed for germ tube length. Greatest reduction in spore germination was by 25% in R. stolonifer and 71% in F. oxysporum Germ tube length reduction for R. stolonifer was by 24–76%, the greatest occurring at 35-min exposure, while for F. oxysporum it was 5–83%, the greatest occurring at 40 min exposure.

Conclusions
These observations reveal the toxicity of the gasses emitted to the growth of the two filamentous fungi and the potential harmful effect to other fungi which might be useful in the ecosystem as decomposers and to those that may be pathogenic to higher plants.
Unique Genomic Landscape of High-Grade Neuroendocrine Cervical Carcinoma: Implications for Rethinking Current Treatment Paradigms
Authors: Eskander Ramez N. , Elvin Julia , Gay Laurie , Ross Jeffrey S. , Miller Vincent A. , Kurzrock Razelle 
Published: September 2020

PURPOSE High-grade neuroendocrine cervical cancer (HGNECC) is an uncommon malignancy with limited therapeutic options; treatment is patterned after the histologically similar small-cell lung cancer (SCLC). To better understand HGNECC biology, we report its genomic landscape. PATIENTS AND METHODS Ninety-seven patients with HGNECC underwent comprehensive genomic profiling (182-315 genes). These results were subsequently compared with a cohort of 1,800 SCLCs. RESULTS The median age of patients with HGNECC was 40.5 years; 83 patients (85.6%) harbored high-risk human papillomavirus (HPV). Overall, 294 genomic alterations (GAs) were identified (median, 2 GAs/sample; average, 3.0 GAs/sample, range, 0-25 GAs/sample) in 109 distinct genes. The most frequently altered genes were PIK3CA (19.6% of cohort), MYC (15.5%), TP53 (15.5%), and PTEN (14.4%). RB1 GAs occurred in 4% versus 32% of HPV-positive versus HPV-negative tumors ( P < .0001). GAs in HGNECC involved the following pathways: PI3K/AKT/mTOR (41.2%); RAS/MEK (11.3%); homologous recombination (9.3%); and ERBB (7.2%). Two tumors (2.1%) had high tumor mutational burden (TMB; both with MSH2 alterations); 16 (16.5%) had intermediate TMB. Seventy-one patients (73%) had ≥ 1 alteration that was theoretically druggable. Comparing HGNECC with SCLC, significant differences in TMB, microsatellite instability, HPV-positive status, and in PIK3CA, MYC, PTEN, TP53, ARID1A, and RB1 alteration rates were found. CONCLUSION This large cohort of patients with HGNECC demonstrated a genomic landscape distinct from SCLC, calling into question the biologic and therapeutic relevance of the histologic similarities between the entities. Furthermore, 73% of HGNECC tumors had potentially actionable alterations, suggesting novel treatment strategies for this aggressive malignancy.
A novel tool for improving the interpretation of isotope bone scans in metastatic prostate cancer
Authors: Alshehri ALI H.D. , Osman Sarah O.S. , Prise Kevin M. , Campfield Caoimhghin , Turner PG , Jain Suneil FRCR PhD , O’Sullivan Joe M. , Cole Aidan J. 
Published: September 2020

Objectives: The isotope bone scan (IBS) is the gold-standard imaging modality for detecting skeletal metastases as part of prostate cancer staging. However, its clinical utility for assessing skeletal metastatic burden is limited due to the need for subjective interpretation. We designed and tested a novel custom software tool, the Metastatic Bone Scan Tool (MetsBST), aimed at improving interpretation of IBSs, and compared its performance with that of an established software programme. Methods: We used IBS images from 62 patients diagnosed with prostate cancer and suspected bone metastases to design and implement MetsBST in MATLAB by defining thresholds used to identify the texture and size of metastatic bone lesions. The results of MetsBST were compared with those of the commercially available automated Bone Scan Index (aBSI) with regression analysis. Results: There was strong agreement between the MetsBST and aBSI results (R2 = 0.9189). In a subregional analysis, MetsBST quantified the extent of metastatic disease in multiple bone sites in patients receiving multimodality therapy (radium-223 and external beam radiotherapy) to illustrate the differences in bone metastatic response to different treatments. Conclusion: The results of MetsBST and the commercial software aBSI were highly consistent. MetsBST introduces novel clinical utility by its ability to differentiate between the responses of different bone metastases to multimodality therapies. Advances in knowledge: MetsBST reduces the variability in assessment of tumour burden caused by subjective interpretation. Therefore, it is a useful aid to physicians reporting nuclear medicine scans, and may improve decision-making in the treatment of metastatic prostate cancer.
Desvelando processos formativos das práticas extensionistas em Educação Popular na saúde
Authors: Cruz Pedro , Vasconcelos Eymard Mourão 
Published: September 2020

Esse artigo pretende explicitar elementos pedagógicos das práticas de extensão orientadas pela educação popular. Foi construído com as metodologias da consulta documental e pesquisa bibliográfica, por meio das quais foram levantados depoimentos de estudantes extensionistas, com ênfase em suas percepções acerca dos processos de aprendizagem. Apontaram-se então pressupostos e desafios da extensão em educação popular no desenvolvimento de um agir crítico em saúde. A extensão em educação popular desvela uma aprendizagem que, ao mesmo tempo, não se restringe à dimensão técnica e é tecida em meio ao trabalho social para a garantia do direito à saúde. Das dimensões reveladas, destacaram-se: extensão como espaço mobilizador de uma pedagogia reorientadora da formação em saúde; mergulho na realidade social e em suas complexidades como etapa fundadora desse processo; perplexidade estudantil (diante das experiências) como processo a ser valorizado, acolhido e problematizado. Tal processo demanda espaços reflexivos com acolhimento e problematização das emoções e das percepções estudantis diante de sua inserção na realidade. Nesses espaços, desvelam-se as estratégias para a construção dos aprendizados significativos na direção do trabalho em saúde orientado pela integralidade, pela promoção humana e pelo compromisso com os grupos socialmente excluídos.
A literatura frenética finissecular nos folhetins de Gomes Leal
Authors: Batalha Maria Cristina 
Published: September 2020

A produção novelística de António Duarte Gomes Leal (1848-1921), um dos mais novos da Geração de 70, é marcada por uma tensão erótica, entre o delírio e o mistério, nos moldes da chamada “literatura frenética”, dominante, na França, nos meados do século XIX, e mais para o fim do século, em Portugal, coincidindo com o período conhecido por “decadentismo”. Em sua obra, Eros é submetido à dor e à morte, e as paixões violentas se desenvolvem em locais soturnos, imersos em escuridão, nos quais predomina o sentimento de aprisionamento face ao exterior (cemitérios, castelos). O satanismo manifesta-se no gosto pelo excesso e o arrebatamento. Através de três novelas de Gomes Leal, publicadas em fascículos como brinde aos leitores do jornal Diário de Notícias, destacam-se a concepção de um universo marcado pelo fantástico e o grotesco, pelo masoquismo e o sadismo, expressando uma visão dualista do homem, inspirada em Baudelaire, e bem ao gosto dos leitores dos folhetins do final do século XIX.
A service evaluation of a specialist migrant maternity service from the user's perspective
Authors: Filby Alex , Robertson Wendy , Afonso Eugenia 
Published: September 2020

Background Meeting the complex needs of pregnant migrants requires an innovative approach. Migrant women's experiences and opinions should directly guide service development if these needs are to be met effectively. Aims To evaluate the specialist migrant maternity service provided by Kings College Hospital London based upon users' experience and satisfaction. Methods A qualitative service evaluation via semi-structured, multi-lingual, in-depth interviews with 10 service users. Data was analysed using a general inductive approach for thematic analysis. Findings Positive aspects: access to midwife and referrals, provision of essentials and transport, respect and kindness of caregivers. Negative aspects: poor maternal nutrition, lack of access to hygienic infant-feeding equipment, lack of social support building and lack of service signposting. Conclusion Women conveyed a high level of satisfaction with the service. The negative aspects that persist are, arguably, not within the immediate remit of the maternity team, yet they negatively affect the health of these women, and therefore merit awareness raising if holistic care is to be achieved. Seven service recommendations have been made.
Maternal and neonatal outcomes for the gentle caesarean section in breech presentation
Authors: Brethouwer Christa H , Scherjon Sicco A , Elvan-Taşpinar Ayten 
Published: September 2020

Background The gentle caesarean section (GCS) is an alternative to the conventional caesarean section. It aims to optimise the wellbeing of mother and child by mimicking certain aspects of a vaginal delivery when a caesarean section is indicated. Aim To compare the maternal and neonatal outcomes of a GCS in cephalic and breech presentation. Methods In this retrospective study, the outcomes of 180 women who underwent a GCS were analysed, where 120 fetuses were in cephalic and 60 were in breech position. Comparisons were made using Chi-square, Mann-Whitney U and t-tests. Maternal and neonatal outcomes were analysed. Results Apgar 1 was significantly lower for breech position (P=0.019). The Apgar 5 and 10 showed no difference. Neonatal temperature was slightly lower in breech position (36.8°C ± 0.36 versus 36.9°C ± 0.39, P=0.046). Birthweight was significantly lower for breech position (P=0.009). Blood loss was significantly higher in cephalic position (441 ± 230 versus 353 ± 151, P=0.002). Conclusions When performing a GCS, there is no clinically significant difference in maternal or neonatal outcome between a cephalic and a breech presentation. It seems safe to perform a GCS for breech presentation.
Leonardo’s Brain: Understanding da Vinci’s Creative Genius, Leonard Shlain (2014)
Authors: Morrison James C. 
Published: September 2020

Abstract

Leonardo’s Brain: Understanding da Vinci’s Creative Genius, Leonard Shlain (2014)
Guilford, CT: Lyons Press, an imprint of Rowman & Littlefield, 256 pp.,
ISBN 978-1-49300-335-8, h/bk, $25.95,
ISBN 978-1-49300-939-8, p/bk, $18.95,
ISBN 978-1-49152-985-0, CD audio, $14.95
Mi calle favorita
Authors: Carinhas Raquel , Araújo e Sá Maria Helena , Moore Danièle 
Published: September 2020

Este trabalho faz parte de uma investigação em curso e visa analisar um conjunto de atividades de um projeto plurilingue e interdisciplinar, concebido e implementado em Montevideu, Uruguai, em 2019, por uma rede de atores educativos integrando professores, mediadores de museus, famílias e investigadores. O projeto inscreve-se dentro de uma abordagem do plurilinguismo como meio e finalidade (GROMMES; HU, 2014) e pretende estabelecer espaços de continuidade entre as aprendizagens na escola, nas famílias e na comunidade, numa perspetiva ecológica da paisagem do lugar. Pretende também promover o reconhecimento da diversidade linguística e cultural e da dimensão multissituada do conhecimento. Foram recolhidos dados multimodais, compreendendo documentação visual e sonora da paisagem linguística da Ciudad Vieja, desenhos e colagens produzidos pelas crianças, registos audiovisuais das diversas atividades e diário de investigação. Nesta contribuição, discutimos as implicações das paisagens linguísticas (PL) como instrumento para a criação de cenários pedagógicos interdisciplinares promotores de aprendizagens multissituadas e de reflexões críticas em torno do plurilinguismo e da multimodalidade, bem como as incidências destes cenários na apropriação e (re)conceptualização do espaço que rodeia os aprendentes na relação com o desenvolvimento da sua identidade. O estudo demonstra o potencial das PL como espaços de aprendizagem e como recursos contextuais para uma maior sensibilização para a diversidade linguística e cultural.
Peningkatan Self Awareness Anak Usia Dini Melalui Media Video Mitigasi Bencana Gunung Meletus
Authors: Ningtyas Dhita Paranita , Risina Duana Fera 
Published: September 2020

This study aims to improve children's self-awareness in disaster response, especially volcanic eruptions with result that children are able to understand the danger of volcanic eruptions since early and have an awareness through a disaster. The subjects were children in group B TK Pertiwi 1 and 2 Samiran, aged 5-6 years. The study was carried out in the village of Samiran because it was an area under the foot of Mount Merapi and Merbabu. This study uses "Action Research" with 2 implementation cycles. This uses Kemmis and MC Taggart procedure which consist of four components, includes: a) planning, b) acting, c) observing, d) reflecting The results are expected that eruption of mountain disaster mitigation videos can improve self-awareness in disaster response so that children have the provision to save themselves and preserve the environment so that the small number of victims because the understanding of disaster mitigation has been obtained since childhood early.
Characteristics of Students Who Opted In to Use the Boost Mobile App as an Educational Support Service
Authors: Andrews Carolyn , Motz Benjamin , Israel Jamie , Leary Heather 
Published: September 2020

This exploratory study aimed to investigate the characteristics of students who opted-in to use Boost, an automated student support mobile app and compare characteristics of non-Boost users. Boost is a mobile app that integrates with the Learning Management System (Canvas) and provides support services aimed at improving student behavior and success. At the start of the Spring 2019 semester at Indiana University, instructors were invited to opt-in for Boost to be available to their classes. Instructors who opted-in invited their students to use Boost. Our multivariate analysis of variance (MANOVA) compared those who opted-in for automated support with those who did not (n=158 courses). Findings reveal that opt-ins were more likely to be Asian, International, and despite having higher college entrance exam scores and being farther along in their studies, opt-ins were slightly lower performing than their peers who did not opt-in. A profile of Boost users will help university administration, student support services, and instructors make data-informed decisions on optimal use of Boost.
Pedagogía de la liberación en medio de la globalización
Authors: Parada Silva Juan Alexis 
Published: September 2020

El presente escrito aspira a presentar una propuesta alternativa a la velocidad de escape que impulsan las nuevas tecnologías de información y comunicación en nuestros días. La propuesta pedagógica está anclada en los trabajos del educador brasileño Paulo Freire, en esta propuesta se resaltan los siguientes elementos: a) el diálogo como método de liberación; b) educar para la comprensión; c) aprender a vivir juntos: la enseñanza de la tolerancia y del respeto al otro son las banderas de la pedagogía liberadora impulsada por Freire. La propuesta pretende crear el espacio propicio para la interacción, para la disertación. La educación debe entablar un diálogo liberador, donde se diriman los conflictos. La educación propuesta por Freire promueve un sujeto transformador, creador y recreador de la realidad; esa realidad que exige que se ajuste, que se apropie de las creaciones humanas como las TIC. El cuerpo de este estudio está conformado por: 1. La era globalizante: repercusiones de la globalización en el mundo. 2. Ventajas de las TIC, para nuestro mundo globalizado. 3. Desventajas de la implementación de las TIC. 4. Una propuesta diferente.
Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression
Authors: Herrero Eva , Stinus Sonia , Bellows Eleanor , Berry Lisa K , Wood Henry , Thorpe Peter H 
Published: September 2020

Abstract
Most cell divisions are asymmetric with some cellular components distributed preferentially to one of the two nascent daughter cells. These asymmetries are typically important for the developmental fate of the resulting daughter cells. Herrero et al. describe .....