bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of the Number of Brazilian Women Living With Metastatic Breast Cancer
Authors: Reinert Tomás , Pellegrini Rodrigo , Rol Rodrigo , Werutsky Gustavo , Barrios Carlos Henrique 
Published: February 2020

PURPOSE Breast cancer is the most common cancer and the leading cause of cancer-related death in women worldwide. The number of women living with metastatic breast cancer (MBC) in Brazil is unknown. The objective of this article was to use population-based data to estimate the prevalence of MBC in Brazil. METHODS Using 4 different sources and cancer registries (DataSUS, Registro Hospitalar de Câncer, the Brazilian National Health Agency, and the National Geography and Statistics Institute) with data from 2008 to 2018, we built a database that represents Brazilian MBC cases. The current number of women in the model living with MBC was considered the prevalence (recurrent or de novo), and new cases in the year 2018 represented the incidence. In each of these outcomes, we were able to separate our population on the basis of cancer subtype, age, and time from diagnosis. RESULTS We estimate that 44,642 women currently live with MBC in Brazil. This accounts for one in every 2,409 Brazilian women and approximately 41 women per 100,000. A total of 58% have hormone receptor–positive/human epidermal growth factor receptor 2–negative tumors, 25% are human epidermal growth factor receptor 2–positive, and 16% have triple-negative breast cancer. According to our methodology, the estimated median overall survival of Brazilian women after diagnosis of MBC is 26.2 months. CONCLUSION The significant number of patients living with MBC should inform and raise the interest of the many stakeholders involved. This collaborative effort is a clear requirement to improve the lives of these patients as well as to prepare for future challenges related to the trend of a progressive increase in MBC prevalence.
Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium
Authors: Gagniac Laurine , Rusidzé Mariam , Boudou Frederic , Cagnet Stephanie , Adlanmerini Marine , Jeannot Pauline , Gaide Nicolas , Giton Frank , Besson Arnaud , Weyl Ariane , Gourdy Pierre , Raymond-Letron Isabelle , Arnal Jean-Francois , Brisken Cathrin , Lenfant Francoise 
Published: February 2020

ABSTRACT
17β-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ERα. ERα acts as a transcription factor but also elicits rapid signaling through a fraction of ERα expressed at the membrane. Here, we have used the C451A-ERα mouse model mutated for the palmitoylation site to understand how ERα membrane signaling affects mammary gland development. Although the overall structure of physiological mammary gland development is slightly affected, both epithelial fragments and basal cells isolated from C451A-ERα mammary glands failed to grow when engrafted into cleared wild-type fat pads, even in pregnant hosts. Similarly, basal cells purified from hormone-stimulated ovariectomized C451A-ERα mice did not produce normal outgrowths. Ex vivo, C451A-ERα basal cells displayed reduced matrix degradation capacities, suggesting altered migration properties. More importantly, C451A-ERα basal cells recovered in vivo repopulating ability when co-transplanted with wild-type luminal cells and specifically with ERα-positive luminal cells. Transcriptional profiling identified crucial paracrine luminal-to-basal signals. Altogether, our findings uncover an important role for membrane ERα expression in promoting intercellular communications that are essential for mammary gland development.
Sheltered employment in schizophrenia is related to disorganization symptoms, processing speed and metaphor comprehension
Authors: Daren Artur , Adamczyk Przemysław , Błądziński Piotr , Sułecka-Stelmach Aleksandra , Starowicz-Filip Anna , Gawęda Łukasz , Kalisz Aneta , Cechnicki Andrzej 
Published: February 2020

Cel pracyZnaczenie deficytów funkcjonowania poznawczego w schizofrenii jest obecnie powszechnie uznawane. Niemniej, związki pomiędzy umiejętnościami poznawczymi niższego i wyższego rzędu oraz ich związek z posiadaniem pracy są stosunkowo słabiej przebadane. Przeprowadzenie analizy dotyczącej tych kwestii było celem niniejszego badania.MetodaBadanie objęło 62 osoby chorujące na schizofrenię, w tym 33 pracujące w ramach zatrudnienia chronionego a 29 uczestniczących w terapii zajęciowej. Zostały one przebadane za pomocą testów funkcji poznawczych z uwzględnieniem umiejętności komunikacyjnych. Objawy psychopatologiczne oceniono za pomocą skali PANSS.WynikiBadane obszary funkcjonowania poznawczego okazały się być powiązane zarówno między sobą jak i z objawami pozytywnymi, negatywnymi i dezorganizacji. Z kolei analiza regresji wykazała, że posiadanie zatrudnienia chronionego związane jest z krótszym czasem reakcji, lepszym rozumieniem metafor oraz mniejszym nasileniem objawów dezorganizacji.WnioskiLiczne powiązania pomiędzy podstawowymi i wyższymi funkcjami poznawczymi podtrzymują koncepcję zgeneralizowanej dysfunkcji poznawczej w schizofrenii. Poza objawami psychopatologicznymi, z posiadaniem pracy przez osoby chorujące związane są także ich podstawowe i wyższe umiejętności poznawcze. Sugeruje to potencjalne obszary dla rehabilitacji poznawczej, które mogłyby wpłynąć na zatrudnialność osób chorujących.
Relationship between levels of Copeptin, NTproBNP and structural functional parameters of the heart in patients with acute myocardial infarction with ST-segment elevation complicated by pulmonary hypertension
Authors: Syvolap Victor , Zemlianiy Yaroslav , Brick Andrey , Bryleva Vera 
Published: February 2020

Introduction: Acute Myocardial Infarction with ST-Segment Elevation (STEMI) - one of the major causes of morbidity and mortality worldwide, including in Ukraine. The prevalence of pulmonary hypertension (PH) in STEMI significantly is not known due to lack of epidemiological studies in this area. Currently, the prognostic significance of PH in patients with STEMI is not set.Objective: To evaluate the levels of NTproBNP and Copeptin and their relationship with structural and functional features of the heart in patients with STEMI complicated by PH.Materials and Methods: The study involved 85 patients (49 men and 36 women) with STEMI who were treated in intensive care and emergency cardiology for the treatment of patients with myocardial infarction communal non-profit enterprise "City hospital and emergency ambulance" Zaporizhia city council. Patients were divided into two groups: 53 patients with STEMI in the presence of PH (mean age 72,40 ± 2,26 years), 32 patients with STEMI without PH (mean age 67,30 ± 2,12 years).Results: In assessing the clinical anamnesis (Table 1) found that PH mainly develops in the anterior localization of STEMI (73,6%). In patients with STEMI in the presence of PH compared with patients without significant PH frequently observed violations systolic function (64,2%). Significant increasing in the level of copeptin (p <0,05) were found in the serum of patients with acute myocardial infarction in the presence of PH compared with patients with normal pressure in the pulmonary artery (PA). NTproBNP level was also higher in patients with STEMI and PH compared with patients without PH. In patients with STEMI and PH we found reliable positive correlation between the NTproBNP and copeptin level (+0,31; p <0,05), systolic pressure in PA (0,41; p <0,05) and negative correlation between NTproBNP level and ejection fraction (-0,41; p <0,05), stroke volume (-0,42; p <0,05). Copeptin positively correlated with the level of NTproBNP (+0,31; p <0,05), systolic pressure in PA (0,37; p <0,05) and negatively correlated with ejection fraction (-0,30; p <0,05 ).Conclusions: Pulmonary hypertension develops mainly in the anterior localization of STEMI (73,6%) in the presence of systolic dysfunction (64,2%). In patients with STEMI and PH level of NTproBNP and copeptin in serum were increased compared than patients without PH. In patients with STEMI and PH NTproBNP and copeptin levels correlated with decreased left ventricular ejection fraction and increased pressure in the pulmonary artery.
Impact of Slatted Floor Configuration on Manure Drainage and Growth Performance of Finishing Pigs
Authors: Wang Hao , Zeng Yaqiong , Pu Shihua , Yang Feiyun , Shi Zhengxiang , Liu Zuohua , Long Dingbiao 
Published: February 2020

HighlightsUnder the same conditions of cast-iron usage, increasing the width of the gap and slat width within a certain range can enhance the bearing capacity of the slatted floors.Variations in the gap and slat width do not significantly affect pig growth performance.The recommended gap width of a cast-iron slatted floor in a fattening pig house is 15 mm.Abstract.Slatted flooring is an important part of the structure of pig houses and can aid in the removal of pig manure to underground ditches via gravity and locomotion. In this study, four different cast-iron slatted floor configurations with different gap widths (10, 15, and 20 mm) and slat widths (10 and 15 mm) were set up in 11 partially slatted-floor pig pens of the same size, each housing 10 fattening pigs with body weights of approximately 63 kg. The residual manure on the solid concrete floor area and a cast-iron slatted floor area were collected at different time intervals (24, 48, and 72 h) and weighed. According to previous studies on total manure and total urine production of pigs, the manure drainage capacity of four types of slatted floor was calculated. The growth performance of all of the pigs was monitored throughout the experiment. The ultimate bearing capacity of the four types of slatted floors was measured by a third-party professional testing organization. The results showed that the gap width and slat width of the cast-iron slatted floor had significant effects on its ultimate bearing capacity and manure drainage capacity (P&lt;0.05) but had no significant effect on pig growth performance (P&gt;0.05). The recommended gap width of a cast-iron slatted floor in a fattening pigs house is 15 mm. These findings can be used to optimize the design of cast-iron slatted flooring for fattening pigs, which must also be safe, economical, and efficient. Keywords: Cast iron, Dimensions, Fattening pig, Manure drainage, Slatted floor.
Criterion for optimizing high-power acousto-optically Q-switched self-Raman yellow lasers with repetition rates up to 500  kHz
Authors: Chen Y. F. , Chen K. Y. , Liu Y. C. , Chen C. M. , Tsou C. H. , Liang H. C. 
Published: February 2020

The criterion for optimizing the high-power acousto-optically

Q

-switched self-Raman yellow laser is originally explored for the repetition rate within 100–500 kHz. The minimum allowed value for the gate-open time is experimentally verified to be determined by the pulse buildup time. By using the minimum allowed gate-open time, the highest conversion efficiency can be achieved to raise the output power by approximately 20% in comparison with the conventional results. At a repetition rate of 200 kHz, the maximum output power at 588 nm can be up to 8.8 W at an incident pump power of 26 W. Furthermore, a practical formula is developed to accurately calculate the threshold pump power as a function of the gate-open time for a given repetition rate.
High-performance mid-wavelength InAs avalanche photodiode using AlAs0.13Sb0.87 as the multiplication layer
Authors: Huang Jianliang , Zhao Chengcheng , Nie Biying , Xie Shiyu , Kwan Dominic C. M. , Meng Xiao , Zhang Yanhua , Huffaker Diana L. , Ma Wenquan 
Published: February 2020

We report on a high-performance mid-wavelength infrared avalanche photodetector (APD) with separate absorption and multiplication regions. InAs is used as the absorber material and high-bandgap

AlAs
0.13

Sb
0.87

is used as the multiplication material. At room temperature, the APD’s peak response wavelength is 3.27 μm, and the 50% cutoff wavelength is 3.5 μm. The avalanche gain reaches 13.1 and the responsivity is 8.09 A/W at 3.27 μm when the applied reverse bias voltage is 14.6 V. The measured peak detectivity

D

⋆

of the device is

2.05
×

10

9

cm
·

Hz

0.5

/
W

at 3.27 μm.
Forschung in Digitalen Innovationsprojekten – zwischen Praxistauglichkeit und wissenschaftlicher Relevanz
Authors: Scheplitz Tim , Benedict Martin , Schlieter Hannes , Kaczmarek Stefanie , Susky Marcel 
Published: February 2020

ZusammenfassungErgebnisse Digitaler Innovationsprojekte (DIP) sind zumeist neue Artefakte von Informationssystemen, welche stark an die Resultate gestaltungsorientierter Forschung erinnern – dem sogenannten Design Science. Dennoch halten die Erkenntnisse aus DIP der Praxis nicht hinreichend Einzug in die wissenschaftliche Gemeinschaft. So zum Beispiel im Gesundheitswesen. Hier werden zwar verstärkt DIP forciert, ihre zentralen Erkenntnisse zur erfolgreichen Gestaltung jedoch selten in die Community transportiert. Ebenso wenig haben sich abseits klassischer Publikationswege Standards zur Kommunikation von erarbeitetem Wissen etabliert. Explizites und implizites Wissen, als Projektresultate nebst der Innovation selbst, können für die Organisation und Durchführung von vergleichbaren Projekten von kritischer Bedeutung sein kann. Ihre Kommunikation und strukturierte Bereitstellung wurden bislang in der Wissenschaft wenig adressiert. Das Ziel dieses Beitrags ist daher einen Weg aufzuzeigen, wie Wissen aus DIP im Gesundheitswesen besser extrahiert und kommuniziert werden kann. Dazu wird ein bestehender Ansatz zur Systematisierung gestaltungsorientierter Forschungsprojekte, das Design Science Grid, in drei Fallstudien angewendet. Aus dieser Anwendung werden sieben verschiedene Typen von Wissen beschrieben, die aus DIP im Gesundheitswesen resultieren können. Für künftige Praxis-Forschungs-Projekte wird damit ein Weg zur Systematisierung von Ergebnissen aufgezeigt. Die gefundenen Wissenstypen können dabei als Ausgangspunkt einer Klassifizierung von zu erzielenden Kontributionen dienen.
British girls' comics: An interview with Wilf Prigmore
Authors: Round Julia 
Published: February 2020

Abstract
Writer and editor Wilf Prigmore worked at Fleetway/IPC in the 1970s. He was group editor for Girls' Adventure Comics, co-creator of Misty (1978–80) and editor of Tammy (1971–84), amongst many other roles. The following interview is taken from conversations with Wilf by telephone, e-mail and in person, between November 2016 and December 2019.
A história da ciência em libros didáticos do 5° ano do ensino fundamental no Brasil e em Taiwan
Authors: Rodio Saucedo Kellys Regina , Chen Miao Shen , Wendling Cleria Maria , Malacarne Vilmar 
Published: February 2020

La presente investigación comprende el análisis de contenidos de Historia de la Ciencia en libros didácticos de Ciencias Naturales utilizados en escuelas de Enseñanza Fundamental y años iniciales. En concreto, se constituyeron como objeto de estudio los libros didácticos del 5º año seleccionados –por los municipios de Cascavel, Paraná (BR) y de Kaohsiung (高雄), Taiwán (台灣)– para uso en las aulas. En el caso de los libros de texto, se basan en las siguientes problemáticas: "¿cuáles son los contenidos de Historia de las Ciencias y cómo se abordan en estos libros didácticos?". Y, basados en el instrumento analítico, elaborado por Laurinda Leite, procedemos a la argumentación acerca de tres dimensiones categóricas: tipo y organización de la información histórica; propuestas de actividades que involucran la Historia de la Ciencia; y el estado del contenido histórico. Los resultados, emanados de la investigación cualitativa de los libros nacionales e internacionales, indicaron la presencia de contenidos sobre la Historia de las Ciencias en todos los libros analizados. Teniendo, sin embargo, especificidades en cuanto a la presentación de esos contenidos. En el estudio fue posible todavía plantear consideraciones sobre el potencial de los estudios comparativos para la comprensión de las concepciones sobre la enseñanza de la Ciencia aplicada en esos países.
SELF-NARRATIVES OF BRAZILIAN DEAF PEOPLE: APPLICATION OF THE HYPOTHESES OF SOCIOANALYSES
Authors: PEDROSA CLEIDE EMILIA FAYE 
Published: February 2020

The objective of the study is to apply eight hypotheses of the socioanalysis for the interpretation and critical social reading of the "self-narratives" of deaf applicants to Higher Education at the Federal University of Sergipe (UFS-Brazil). It is located in the theoretical-methodological field of Critical Discourse Analysis (CDA), and Deaf Studies (DS). We will analyze a narrative of a deaf subject, corpus collected in 2014, in the college entrance examination for the Brazilian Sign Language Course (LIBRAS), and adopt this methodological guideline, to define object of study; identify areas of interfaces that meet the objectives; select the categories of each area of interface; establish the dialogue between categories; identify the social meanings constructed in the discourse. The result confirms the role of socioanalysis in seeking to unveil how the practice of social relations and (re)construction of their identities in the struggle for citizenship rights articulate in the deaf individual's life.
Composition, Anticholinesterase and Antipedicular Activities of Satureja capitata L. Volatile Oil
Authors: Jaradat Nidal , Adwan Lina , Zaid Abdel Naser , K’aibni Shadi , Arar Mohammad 
Published: February 2020

AbstractThe emergence of resistance for antipedicular agents and the need of potent acetylcholinesterase (AChE) therapeutics for the treatment of a neurodegenerative disorder such as Alzheimer disease has led researchers to the exploration of new therapeutic alternatives such as natural volatile oils. Therefore, the current investigation aimed to identify the components of Satureja capitata L. volatile oil (VO), and examine the VO anticholinesterase, and antipedicular activities. The plant phytoconstituents were identified using Gas chromatography mass spectrometry (GC-MS) method, while the anticholinesterase activity was determined against butyryl- and acetyl-cholinesterase using Ellman’s method. In addition, antipedicular activity was established using the diffusion method. The obtained GC-MS results identified 16 compounds in S. capitata VO with the major constituents being carvacrol, γ-terpinene, and p-cymene. Anticholinesterase analysis showed a marked inhibition potential against acetyl- and butyryl-cholinesterase enzymes with half maximal inhibitory concentration (IC50) values of 28.24±0.97 μg/ml and 92.31±1.22 μg/ml, respectively in comparison with the reference compound galantamine, which has IC50 values against the same enzymes of 5.21±0.07 μg/ml and 10.33±0.37 μg/ml, respectively. In addition, the VO, at a concentration of 20%, was effective against head lice, similar to benzyl benzoate, which resulted in 100% mortality. In addition, the VO completely inhibited the emergence of lice nits after 6 and 14 days. On the basis of the obtained results, S. capitata VO is a promising natural alternative to synthetic antipedicular and anticholinesterase drugs, which can be employed in drug development, and may lead to new candidates against head lice and neurodegenerative diseases.
A characterization of real holomorphic chains and applications in representing homology classes by algebraic cycles
Authors: Teh Jyh-Haur , Yang Chin-Jui 
Published: February 2020

AbstractWe show that a 2k-current T on a complex manifold is a real holomorphic k-chain if and only if T is locally real rectifiable, d-closed and has ℋ2k-locally finite support. This result is applied to study homology classes represented by algebraic cycles.
The Use of Logic Regression in Epidemiologic Studies to Investigate Multiple Binary Exposures: An Example of Occupation History and Amyotrophic Lateral Sclerosis
Authors: Bellavia Andrea , Rotem Ran S. , Dickerson Aisha S. , Hansen Johnni , Gredal Ole , Weisskopf Marc G. 
Published: February 2020

Abstract
Investigating the joint exposure to several risk factors is becoming a key component of epidemiologic studies. Individuals are exposed to multiple factors, often simultaneously, and evaluating patterns of exposures and high-dimension interactions may allow for a better understanding of health risks at the individual level. When jointly evaluating high-dimensional exposures, common statistical methods should be integrated with machine learning techniques that may better account for complex settings. Among these, Logic regression was developed to investigate a large number of binary exposures as they relate to a given outcome. This method may be of interest in several public health settings, yet has never been presented to an epidemiologic audience. In this paper, we review and discuss Logic regression as a potential tool for epidemiological studies, using an example of occupation history (68 binary exposures of primary occupations) and amyotrophic lateral sclerosis in a population-based Danish cohort. Logic regression identifies predictors that are Boolean combinations of the original (binary) exposures, fully operating within the regression framework of interest (e. g. linear, logistic). Combinations of exposures are graphically presented as Logic trees, and techniques for selecting the best Logic model are available and of high importance. While highlighting several advantages of the method, we also discuss specific drawbacks and practical issues that should be considered when using Logic regression in population-based studies. With this paper, we encourage researchers to explore the use of machine learning techniques when evaluating large-dimensional epidemiologic data, as well as advocate the need of further methodological work in the area.
The crystal structure of a matrine derivative, 13-(methylamine-1-yl) carbodithioate matrine, C17H27N3OS2
Authors: Hui-Qing He , Fang-Yun Dong , Han-Hui Zhang , Jing-Min Ye , Chun-Can Tan , Xu-Hong Jiang , Zi-Zhao Zheng , Xiao-Jing Lv , Xing-An Cheng 
Published: February 2020

Abstract
C17H27N3OS2, monoclinic, P21 (no. 4), a = 8.8052(10) Å, b = 10.8860(10) Å, c = 18.6705(2) Å, β = 99.2730(10)°, V = 1766.24(3) Å3, Z = 4, Rgt
(F) = 0.0298, wR
ref(F
2) = 0.0802, T = 100.00(10) K.
One state that emerged from others. The image of Polish-Lithuanian Commonwealth in Alessandro Guagnini’s writings
Authors: Gis Kacper 
Published: February 2020

Abstract
Research concerning the history of government and administration should be based not only on historical documents (like legal acts) but also narrative or literary sources such as chronicles. These texts contain large amounts of information about old forms of administration. A good example of that kind of narrative source is the description of European Sarmatia written by Alessandro Guagnini. The author of this text was Italian, who lived in the Polish-Lithuanian Commonwealth at the turn of sixteenth and seventeenth century. This text was a historical and geographical relation about the Polish-Lithuanian Commonwealth and its neighbours. It was reprinted in different editions and in few languages having a considerable impact on a perception of abovementioned state and even Central and Eastern Europe as well.
In modern times Guagnini’s works have been quite forgotten, nevertheless its renewed analysis leads to interesting information at various levels. One of them is presentation of government model in the Polish-Lithuanian Commonwealth. The described state consisted of few great regions each of which had its own administrative division, history and customs. Together they merged into a great political entity ruled by one monarch and approaching unification.
The purpose of this article is to present administrative division in the pages of the described chronicle and how that division was ideologically legitimated by appealing to ancient Sarmatia.