bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting evidence-based clinical practice guidelines for people with attention deficit hyperactivity disorder in Saudi Arabia: process and outputs of a national initiative
Authors: Bashiri Fahad A. , Albatti Turki H. , Hamad Muddathir H. , Al-Joudi Haya F. , Daghash Hadeel F. , Al-Salehi Saleh M. , Varnham Jeremy L. , Alhaider Fatimah , Almodayfer Omar , Alhossein Abdulkarim , Aldhalaan Hesham , Aldabbagh Yasser A. , Backer Nouf Al , Altwaijri Waleed , Alburikan Khalid , Buraik Maysaa , Ghaziuddin Mohammad , Nester Michael J. , Wahabi Hayfaa , Alhabib Samia , Jamal Amr A. , Amer Yasser Sami 
Published: July 2020

Abstract
Background: We recently adapted the published National institute for Health and Care Excellence (NICE) Attention deficit hyperactivity disorder (ADHD) diagnosis and management guideline to the Saudi Arabian context. It has been postulated that adaptation of evidence-based clinical practice guidelines to the local healthcare context rather than de-novo development will improve their adoption and implementation without imposing a significant burden on resources. The objective of this paper is to describe the adaptation process methodology utilized for the generation of the first national guideline for management of people with ADHD in Saudi Arabia.Methods: We used the KSU-Modified-ADAPTE methodology for the guideline adaptation process. We describe the full process in detail including the three phases of set-up, adaptation, and finalization. The process was conducted by a multidisciplinary guideline adaptation group in addition to an external review for the clinical content and methodology.Results: The group adapted ten main categories of recommendations from one source CPG (NICE). The recommendations include; (i) service organisation and training, (ii) recognition, identification and referral, (iii) diagnosis, (iv) support, (v) managing ADHD, (vi) dietary advice, (vii) medication, (viii) maintenance and monitoring, (ix) adherence to treatment, and (x) review of medication and discontinuation. Several implementation tools were compiled and developed to enhance implementability including a clinical algorithm, quality measures, coding system, medication tables, translations, patient information, and online resources.Conclusions: The finalized clinical practice guideline provides healthcare providers with applicable evidence-based guidance for the management of people with ADHD in Saudi Arabia. The project also demonstrated the effectiveness of KSU-Modified-ADAPTE, and emphasized the value of a collaborative clinical and methodological expert group for adaptation of national guidelines.
Tephra Deposit Inversion by Coupling TEPHRA2 With the Metropolis-Hastings Algorithm and Its Implications
Authors: Yang Qingyuan , Pitman E Bruce , Bursik Marcus , Jenkins Susanna F 
Published: July 2020

Abstract
In this work we couple the Metropolis-Hastings algorithm with the volcanic ash transport model TEPHRA2, and present the coupled algorithm as a new method to estimate the Eruption Source Parameters of volcanic eruptions based on mass per unit area or thickness measurements of tephra fall deposits. Basic elements in the algorithm and how to implement it are introduced. Experiments are done with synthetic datasets. These experiments are designed to demonstrate that the algorithm works, and to show how inputs affect its performance. Results are presented as sample posterior distribution estimates for variables of interest. Advantages of the algorithm are that it has the ability to i) incorporate prior knowledge; ii) quantify the uncertainty; and iii) capture correlations between variables of interest in the estimated Eruption Source Parameters. A limitation is that some of the inputs need to be specifed subjectively. How and why such inputs affect the performance of the algorithm and how to specify them properly are explained and listed. Correlation between variables of interest are well-explained by the physics of tephra transport. We point out that in tephra deposit inversion, caution is needed in attempting to estimate Eruption Source Parameters, and wind direction and speed at each elevation level, as this increases the number of variables to be estimated. The algorithm is applied to a mass per unit area dataset of the tephra deposit from the 2011 Kirishima-Shinmoedake eruption. Simulation results from TEPHRA2 using posterior means from the algorithm are consistent with field observations, suggesting that this approach reliably reconstructs Eruption Source Parameters and wind conditions from the deposit.
In silico Discovery of anti-SARS-CoV-2 agents via docking screening and ADMET properties
Authors: Hadni Hanine , Elhallaoui Menana 
Published: July 2020

Abstract
The novel coronavirus (SARS-CoV-2) is the causative factor in the COVID-19 pandemic that infected more than 3 million people and the number of deaths continues to rise. There are currently no drugs or vaccines available to treat this disease, which is a serious global health problem. In this study, we performed molecular docking of heterocyclic molecules based on Quinoline, Triazine and Azaaurone, and to increase their inhibitory efficacy, we have used hybrid molecules linking two pharmacophores such as quinoline-oxalamide, quinoline-triazine and azaaurone-triazine. In order to accelerate the drug discovery process against this new SARS-CoV-2. Hydroxychloroquine and Azithromycin drugs showed anti-SARS-CoV-2 activity, which is why we have considered these drugs as a reference for other molecules. Most compounds showed high inhibitory activity against SARS-CoV-2, and promising results in ADMET properties and drug likeness. Thus, these compounds present excellent drug candidates. These results would be of great help in leading discovery and optimization for new drug against novel coronavirus.
In silico screening of Moroccan medicinal plants with the ability to directly inhibit the novel coronavirus, SARS-CoV-2
Authors: Mrid Reda Ben , Bouchmaa Najat , Kabach Imad , Sobeh Mansour , Zyad Abdelmajid , Nhiri Mohamed , Yasri Abdelaziz 
Published: July 2020

Abstract
In the present study, we investigated natural compounds contained in Moroccan medicinal plants and that might be used as natural inhibitors of the novel coronavirus, SARS-CoV-2, that causes coronavirus disease 2019 (COVID-19). We first performed a literature search for natural inhibitors of SARS or MERS coronaviruses. We then selected natural compounds that have been biologically tested and confirmed to possess anti-coronavirus activity. Subsequently, we used a molecular docking to determine whether the selected molecules could interact with the virus proteins. The compounds selected from virtual screening were then subjected to an in-silico analysis of absorption, distribution, metabolism and excretion (ADME) properties to select only natural compounds that could be orally bioavailable. Thereafter, a second search has been launched to select Moroccan medicinal plants that contain at least 3 molecules from those natural compounds. As results, among 41 natural inhibitors of SARS or MERS coronaviruses, only 13 have been successfully passed the ADME filtering. These molecules, showed abilities to interact with the novel coronavirus as it was predicted. Using these molecules and based on the data extracted from literature, 29 Moroccan medicinal plants have been found to contain at least 3 of these coronavirus inhibitors. Therefore, the medicinal plants selected in this study might contain direct anti-SARS-CoV-2 compounds.
A Bibliometric Analysis of Childhood Obesity Research From China Indexed in Web of Science
Authors: Kawuki Joseph , Ghimire Upama , Papabathini Shireen Salome , Obore Nathan , Musa Taha Hussein 
Published: July 2020

Abstract
Background: Childhood obesity (CHO) is a serious global health threat, whose prevalence in China has gradually increased in the past two decades. The study aimed to quantify and map the scientific output of research concerning CHO published from China though a Bibliometric perspective. Methods: CHO-related publications were retrieved from the Web of Science database by using the keywords ‘childhood obesity’, and ‘childhood overweight’. HistCite and Biblioshiny software were used to categorise and evaluate authors’, institutions’ and journals’ contribution. VOSviewer was used for network-visualisation. Results: A total of 230 CHO-related documents were identified from China (1900-2020), which was 3.8% of the global output of CHO research. The majority (74.8%) of the papers were research articles, and the average citations per document were 18.4. The results show a gradual increase in publication trend over the last 20 years. The leading institutions in CHO research were Peking University (n=22), Chinese CDC (19) and Chinese University of Hong Kong (18), while “Endocrinology Metabolism” (50) was the most decisive research field. The most contributing authors included Wang YF (17), Xue H (11), and Ma GS (10), while “Obesity Reviews” (15) was the most-crucial journal. The most cited article was from Olds T et al. published in 2011. Conclusion: This analysis provides a historical perspective of progress in CHO research from China and has highlighted the leading role played by various stakeholders in addressing CHO. Besides, it highlights a need for more focus on CHO research as well as targeted interventions for effective prevention and control.
Evolution and Current State of Global Research on Paediatric Resuscitation: A Systematic Scientometric Analysis
Authors: Scholz Sean S. , Borgstedt Rainer , Menzel Leoni C. , Rehberg Sebastian , Jansen Gerrit 
Published: July 2020

Abstract
Background:Paediatric resuscitation is rare but potentially associated with maximallifetime reduction. Notably, there are still today high infant mortality rates in several nations. To improve clinical outcomes and promote research detailed analyses on evolution and current state of research on paediatric resuscitation are necessary.Methods:Research on paediatric resuscitation published in-between 1900-2019 weresearched using Web of Science. Metadata were extracted and resolved based on the science performance evaluation (SciPE) protocol. Research performance was evaluated regarding quality and quantity over time, including comparisons to adult resuscitation. National research performance was related to population, financial capacities, infant mortality rate, collaborations, and authors gender.Results:Similar to adult resuscitation research performance on paediatric resuscitationgrew exponentially with most original articles being published during the last decade (1,106/1,896). The absolute number, however, is only 14% compared to adults. The United States dominate global research by contributing the highest number of articles (777), Hirsch-Index (70), and citations (18,863). The most productive collaboration was between the United States and Canada (52). When considering nation’s population and gross domestic product (GDP) rate, Norway is leading regarding population per article (62,467), per Hirsch-Index (223,841), per citation (2,226), and per GDP (2.3E- 04). Regarding publications per infant mortality rate, efforts of India and Brazil are remarkable. Out of the 100 most frequently publishing researchers, 25% were female.Conclusion: Research efforts on paediatric resuscitation have increased but remainunderrepresented. Specifically, nations with high infant mortality rates should be integrated by collaborations. Additional efforts are required to overcome gender disparities.
A combination of cytokeratin 5/6, P63, P40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix
Authors: Li Hailing , Jing Xiaotong , Yu Jie , Liu Jiannan , Zhang Tingguo , Chen Shiming , Zhang Xiaofang 
Published: July 2020

Abstract
Purpose
Squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancer. Compared to squamous cell carcinomas, adenocarcinomas are more common in younger women and have a poorer prognosis. Yet, so far, no useful biomarkers have been developed for these two types of cancer. In the following study, we examined the combination of cytokeratin 5/6, P63, P40 and MUC5AC for distinguishing squamous cell carcinoma (SCC) from adenocarcinoma of the cervix (AEC).
Materials and Methods
A total of 101 SCC and 108 AEC were collected. Immunohistochemical analyses were conducted to determine the expression of CK5/6, P63, P40, CK7 and MUC5AC. One pathologist who was blinded to the patient’s clinical and pathological data interpreted the staining results.
Results
MUC5AC and CK7 were detected in 81.48% and 82.41% of AEC cases compared to 9.9% and 49.50% of SCC cases (P < 0.05); the specificity of MUC5AC was higher than that of CK7 in AEC (P < 0.05). The sensitivity of MUC5AC combined with P40 or P63 was similar to that of CK7, but the specificity was slightly higher than that of CK7 in AEC. Moreover, the expression of MUC5AC was correlated with the degree of tumor differentiation in adenocarcinomas (P = 0.036) and was not related to the prognosis of cervical adenocarcinoma and subtypes.
Conclusions
MUC5AC may be useful as a biomarker for differential diagnoses between squamous carcinoma and adenocarcinoma of the cervix.
Assessment of Heavy Metal Concentration in Ujjani Reservoir Water and Sediment, Maharashtra, India
Authors: Shinde Dnyaneshwar , Mahajan Dnyanesh M. , Chakane Sanjay D. 
Published: July 2020

Abstract
The study was conducted to investigate heavy metal contents namely, Iron (Fe), Copper (Cu), Zinc (Zn), and Manganese (Mn) from surface sediment and water samples collected from the Ujjani Reservoir. The concentrations (mg kg− 1) of Fe, Cu, Zn and Mn in sediment detected were 4455.0, 184.05, 97.4, 1090.5 respectively, while in water metal contents (mg l− 1) Fe, Cu, Zn, and Mn were 3.05, 0.5, 0.82, and 2.56 correspondingly. The contents of metals in the studied samples showed a descending order such as Fe, Mn, Zn and Cu. It was observed that the mean concentrations of Fe, Cu, and Mn were more in sediment and water, whereas, Zn contents were detected lesser than the standard levels proposed by USEPA 2004. The sediment pollution analysis was achieved using a Pollution load index (PLI), Geoaccumulation index (Igeo) and Potential ecological risk index (RI). Similarly, risk of metals in water was evaluated using Average absorption dose (ADD), Hazardous quotient (HQ), and Hazardous index (HI). In our study, the ADD, HQ and HI values for metals were lower than 1, indicating that there is no health risk associated with studied heavy metals present in surface water. Also sediment quality assessment shows that there is minor ecological risk of studied heavy metals. Even though, the Ujjani Reservoir has a lower ecological risk, its water and sediment quality is declining day by day. Therefore, there is a need to make a policy for ecological restoration to avoid further damage to the ecosystem and human beings.
MiR-7e-5p downregulation promotes malignant transformation of follicular lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages
Authors: Lou Xiaoli , Fu Jianhong , Zhao Xin , Zhuansun Xuemei , Rong Chao , Sun Maomin , Niu Hui , Wu Lei , Zhang Yongsheng , An Lu , Wan Shan , Wang Shouli 
Published: July 2020

Abstract
Background
In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell lymphoma (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment remodeling account for FL progression. A panel of miroRNA (miRNA) was downregulated in transformed FL.
Methods
Differentially expressed miRNAs were systematically analyzed in tissue samples from patients at different stages of disease. In FL cells, transcriptional regulation of the oncogene c-MYC on its target miR-7e-5p was revealed by Chromatin Immunoprecipitation (ChIP) assay. Exosome, carrying differentially expressed miR-7e-5p was isolated and visualized by transmission electron microscope and fluorescence tracing. The effect of miR-7e-5p on recipient macrophage was determined by target gene quantification, flow cytometry, and TUNEL method in a cocultured system with miR-7e-5p-mimics or inhibitor treatment. Expression of miR-7e-5p targets, macrophage proportions, and clinical parameters were included for correlation analysis.
Results
We determined that downregulation of miR-7e-5p, driven by c-MYC overexpression, was associated with poorer prognosis in FL patients. The decreased expression of miR-7e-5p in lymphoma cells led to a reduced exosomal transfer to surrounding macrophages. As a result, the target gene of miR-7e-5p, Fas ligand (FasL), was upregulated and activated the caspase signaling, which led to the apoptosis of M1 macrophages in tumor stroma. Finally, in transformed FL tissues, overexpression of FasL and activation of caspase proteins was detected in tumor stromal macrophages. Downregulation of miR-7e-5p was associated with poorer clinical outcomes.
Conclusion
Downregulation of exosomal miR-7e-5p induces stromal M1 macrophage apoptosis, which leads to immunosurveillance and transformation of FL.
Dynamic Changes in Plasma Urotensin II and its Correlation with Plaque Stability
Authors: Yin Chunlin , Liu Xue , Wang Hongxia , Yan Mingcong , Guo Lijuan , Li Guonan , Xia Jinggang , Yuan Huihui 
Published: July 2020

Abstract
Background: Urotensin II (UII) is involved in the formation of atherosclerosis, but its role in the stability of atherosclerotic plaque is undetermined. The purpose of this study was to observe the dynamic change of plasma UII and analyze its relationship with the stability of atherosclerotic plaques. Methods: The plasma UII concentration in patients with acute coronary syndrome (ACS) was detected. A vulnerable plaque model was established by local transfection of a recombinant P53 adenovirus into plaques of rabbits fed with a high-cholesterol diet and subjected to balloon injury, to evaluate the stability of the atherosclerotic plaques. ﻿Results: Our results showed that the level of plasma UII was increased in ACS patients compared with healthy subjects. However, it was significantly decreased in ST-segment elevation myocardial infarction patients (STEMI) and increased again in acute myocardial infarction (AMI) patients that were discharged after three months. UII dynamic change and its correlation with plaques stabilities were further verified in rabbit with atherosclerotic vulnerable plaque. The UII level in rabbits was significantly decreased after P53 gene transfection which can lead to of plaque instability. Conclusions: In conclusion, the level of plasma UII was significantly decreased in ACS with STEMI, which may serve as a reliable biological marker to reflect the progression and stability of atherosclerotic plaques.
Efficacy and Safety of Mycophenolate Mofetil Therapy in Neuromyelitis Optica Spectrum Disorders: A Systematic Review and Meta-Analysis
Authors: Songwisit Sakdipat , Kosiyakul Punchika , Jitprapaikulsan Jiraporn , Prayoonwiwat Naraporn , Ungprasert Patompong , siritho sasitorn 
Published: July 2020

Abstract
Background: Neuromyelitis optica spectrum disorders (NMOSD) is an autoimmune demyelinating disease of the central nervous system characterized by severe attacks of optic nerve and spinal cord. Mycophenolate mofetil (MMF) is an immunosuppressive agent (IS) which is widely prescribed for NMOSD patients. This systematic review and meta-analysis aims to assess the efficacy and safety of MMF in controlling relapse and disease severity.Methods: Studies were obtained from the EMBASE and Ovid MEDLINE databases. Eligible studies were the studies of NMOSD patients treated with MMF which reported treatment outcomes as Annualized Relapse Rate (ARR) or Expanded Disability Status Scale (EDSS) before and after treatment. Case reports, case series less than 3 patients, and reviews were excluded.Results: Fifteen studies included 1047 patients, of whom 915 (87.4%) were aquaporin-4 immunoglobulin seropositive. The total number of patients that received MMF was 799. Meta-analysis on ARR and EDSS were conducted in 4 studies with a total of 200 patients and 3 studies with a total of 158 patients, respectively. The result showed a significant improvement with a mean reduction of 1.13 (95% confidence interval (CI), 0.60 to 1.65) in ARR and a mean reduction of 0.85 (95% CI, 0.36 to 1.34) in EDSS after MMF therapy. Adverse drug reactions occurred in 106 (17.8%) of 594 patients that were documented having side effects during MMF therapy.Conclusion: This systematic review and meta-analysis showed that using MMF as a preventive therapy in NMOSD patients can significantly reduce relapse rate and improve disease severity with an acceptable tolerability.
A new method for evaluation of patellar height and the position of the joint line before and after total knee arthroplasty
Authors: Han Hua , Zhang Xiaohui 
Published: July 2020

Abstract
Background: The measurement of patellar height and restoration of the natural position of the joint line are crucial to total knee arthroplasty (TKA). However, there remains a lack of consensus on an optimal measurement method to associate the patellar height with the joint line position. The objective of this study was to introduce a new method and validate the application in TKA both preoperatively and postoperatively.Methods: Instead of taking marginal landmarks as the tibial references, the tibial shaft axis was used to construct the new measurement method, which comprises the axis-patella (AP), joint axis-patella (jAP) indices and joint line height (JLH). Patellar heights were measured using the Insall-Salvati (IS), modified Insall-Salvati (mIS), Blackburne-Peel (BP), Caton-Deschamps (CD) indices, and the new method in 175 knees both preoperatively and postoperatively. Intraclass correlation coefficients and Pearson’s correlation analysis were respectively used to evaluate the reliabilities and correlations.Results: There was good correlation between the proposed method and the mIS, CD, and BP indices. High inter-observer reproducibility was found for AP (preoperative and postoperative 0.83), jAP (preoperative 0.82; postoperative 0.86) indices and JLH (preoperative 0.88; postoperative 0.95). High intra-observer repeatability was also found for AP (preoperative 0.85; postoperative 0.87), jAP (preoperative 0.83; postoperative 0.87) indices and JLH (preoperative 0.80; postoperative 0.92). Conclusions: The new method is reliable for measuring patellar height before and after TKA, providing an alternative to distinguish between true and pseudo patella baja. Furthermore, JLH can be applied to assess and restore the joint line position in TKA.