bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Geospasial Perubahan Penggunaan Lahan dan Kesesuaiannya Terhadap RTRW Kabupaten Purworejo Tahun 2011-2031
Authors: Saputra Virgiawan Aji , Santosa Purnama Budi 
Published: November 2020

Kabupaten Purworejo terletak pada jalur lintas selatan di wilayah Jawa Tengah yang menghubungkan Yogyakarta dengan kota-kota lain di wilayah selatan Jawa Tengah seperti Kutoarjo, Kebumen, Purwokerto, serta kota-kota lainnya. Letak Kabupaten Purworejo yang strategis ini berdampak pada dinamika sosial, ekonomi, dan kependudukan, khususnya pertumbuhan wilayah. Berdasarkan fenomena tersebut, penelitian ini bertujuan untuk mengetahui perubahan penggunaan lahan yang terjadi di Kabupaten Purworejo, serta kesesuaiannya dengan Rencana Tata Ruang Wilayah (RTRW) tahun 2011-2031. Metode yang digunakan adalah pendekatan analisis geospasial untuk melakukan analisis spasial-temporal perubahan spasial penggunaan lahan dari tahun 2008 dan 2013. Hasil analisis perubahan spasial ini kemudian dikorelasiakan dengan peta RTRW Kabupaten Purworejo tahun 2011-2031 untuk mengetahui tingkat kesesuaian pengunaan lahan di Kabupaten Purworejo terhadap RTRW. Hasil penelitian menunjukkan bahwa dalam waktu 5 tahun dari tahun 2008 sampai dengan 2013 terjadi perubahan penggunaan lahan sebesar 0,1%. Perubahan luas penggunaan lahan terbesar terjadi di Kecamatan Grabag dengan persentase 0,71%, sedangkan Kecamatan Ngobol, Bener, Gebang, dan Loano bisa dikatakan tidak mengalami perubahan penggunaan lahan. Ditinjau dari kesesuaian penggunaan lahan terhadap RTRW, maka dapat diperoleh informasi bahwa tingkat kesesuaian penggunaan lahan pada tahun 2013 adalah sekitar 62,21%. Kecamatan Kutoarjo dengan persentase 93,34% merupakan kecamatan dengan persentase penggunaan lahan terbesar sesuai peruntukannya. Sedangkan Kecamatan Bagelen dengan persentase 38,40% merupakan kecamatan dengan persentase penggunaan lahan terkecil sesuai peruntukannya.
A STUDY TO ASSESS THE CONTRAST SENSITIVITY OF THE HUMAN VISUAL SYSTEM IN PATIENTS WITH OR WITHOUT DIABETES IN A TERTIARY CARE HOSPITAL
Authors: RAJGADIA NIKITA , BHASKARAN BINDU , DIVYA N. , VEERAMANI V. PANIMALAR A. , IKRAM SYEDA SADIYA 
Published: November 2020

Objective: The objective of our study was to assess the variations in contrast sensitivity values of normoglycemic subjects and that of type II diabetic subjects of the same age group. It was also aimed at finding the visual acuities and study the associations of it with contrast sensitivity if any.
Methods: It was a hospital-based comparative cross-sectional descriptive study conducted in the out-patient department of the Department of Ophthalmology, Saveetha Medical College, Hospital, Chennai. Visual Acuity and Contrast Sensitivity of 50 Type II Diabetic individuals and 50 age-equivalent control group subjects were measured using the Snellen’s chart and Pelli-Robson chart, respectively, during the months of January to March 2020.
Results: Contrast Sensitivity measurements from 50 subjects with Non-Insulin dependent Diabetes Mellitus (NIDDM) were obtained. The subjects were the ones who had minimal or no diabetic retinopathy. It was observed that there is a significant association between reduced contrast sensitivity and Diabetes (P value<.00008). We also noted that CS may be reduced without corresponding loss of Visual Acuity. Hence, both visual acuity and contrast sensitivity measurements are helpful in the assessment of visual impairment due to diabetic eye disease.
Conclusion: The contrast sensitivity can be seen as an early marker for visual impairment in diabetic eye care.
FORMULATION AND EVALUATION OF OPTIMISED MALTODEXTRIN BASED PRONIOSOME POWDERS CONTAINING BAZEDOXIFENE ACETATE FOR ORAL DELIVERY
Authors: GANDRA SMITHA 
Published: November 2020

Objective: The main objective of the present study was to develop proniosomal formulations to enhance the oral bioavailability of bazedoxifene acetate by improving solubility, dissolution and/or intestinal permeability.
Methods: Proniosomal powder formulations were prepared with bazedoxifene acetate drug varying the span 40 and cholesterol ratio in the range of 0.8:0.2 to 0.2:0.8 using maltodextrin as a carrier by slurry method. The prepared proniosomal powder was filled into capsules. The bioavailability enhancement of proniosomes loaded with drug was studied focusing on non-ionic surfactants composition and drug: span 40 ratio. Prepared proniosomes were characterized for their particle size distribution, zeta potential, entrapment efficiency, in vitro dissolution study and thermal characteristics to understand the phase transition behavior. Further, the formulated proniosomes were subjected to stability behavior, ex vivo permeation studies using rat intestine followed by in vivo studies.
Results: Physico-chemical studies help in the optimization of formulations. Enhancement in dissolution is due to the incorporation of bazedoxifene acetate into the non-ionic surfactant and change in the physical state from crystalline to amorphous, thus improving oral bioavailability. Ex vivo studies show significant permeation enhancement across the gastrointestinal membrane compared to control.
Conclusion: In conclusion, proniosomes provide a powerful and functional way of the distribution of inadequately soluble bazedoxifene acetate drug, which is proved from in vivo studies based on the enhanced oral delivery.
COMPARISON OF POSTOPERATIVE CORNEAL ASTIGMATISM IN PHACOEMULSIFICATION AND MANUAL SMALL INCISION CATARACT SURGERY
Authors: NAIR NAYANTARA , N. DIVYA , PANIMALAR V. , VEERAMANI A. , BHASKARAN BINDU 
Published: November 2020

Objective: Globally a significant proportion of treatable blindness is caused by cataract, especially in India and southeast Asia. Treatment of cataract is surgical correction with intraocular lens implantation. The main drawback of surgical correction is induction of postoperative astigmatism in patients. The aim of this study was to compare the degree of astigmatism in manual small incision cataract surgery and phacoemulsification 3 mo postoperatively
Methods: The study was a retrospective case study on postoperative corneal astigmatism after cataract surgery. It was conducted in a tertiary care hospital in Thandalam, Tamil Nadu. A total of 100 patients were selected and divided into two groups, group A (=50) underwent phacoemulsification and group B (=50) underwent manual small incision cataract surgery. Preoperative astigmatic status of the patients was noted from patient records. Both groups were evaluated 3 mo postoperatively using automated keratometry. The data collected was analyzed using Microsoft Excel Independent T test, p<0.05 was considered statistically significant. Power of the study was 80% with an alpha error of 5%.
Results: Mean postoperative astigmatism at 3 mo was 0.91±0.255D and 0.34±0.110D due to manual small incision cataract surgery and phacoemulsification, respectively.
Conclusion: Postoperative astigmatism was greater in manual small incision cataract surgery than phacoemulsification. Improvement in preoperative astigmatism was seen in patients who underwent superotemporal incision phacoemulsification
PHYTOCHEMICAL ANALYSIS AND IN VITRO DPPH ASSAY OF ETHANOLIC EXTRACT OF MUCUNA PRURIENS SEED
Authors: V. SREEKALA , B. VIJAYKISHAN , RAJASEKAR S. S. , R. RAJESH 
Published: November 2020

Objective: To detect the bioactive phytoconstituents of Mucuna pruriens seed extract and to estimate invitro antioxidant activity.
Methods: Preliminary phytochemical analysis were done to determine the active phytochemical constituents and DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay method was used for the estimation of In vitro antioxidant activity.
Results: Preliminary phytochemical analysis of Mucuna pruriens seed extract showed the presence of chief bioactive components like phenols, flavonoids, tannins, alkaloids, triterpenes and phytosterols. In antioxidant assay, Mucuna pruriens seed extract exhibited a maximum DPPH radical scavenging activity of 72.95% against the standard control with a maximum activity of 93.24% for the same concentration (0.2 mg/ml). This is a clear indication of strong antioxidant property of the drug.
Conclusion: Mucuna Pruriens seeds are abundant source of natural antioxidants, and important bioactive phytoconstituents.
Entrevista al Doctor Santiago Nieto Castillo
Authors: Uscanga Barradas Abril 
Published: November 2020

Santiago Nieto Castillo, Titular de la Unidad de Inteligencia Financiera de la Secretaria de Hacienda y Crédito Público. Fue Fiscal Especializado para la Atención de Delitos Electorales de 2015 a 2017. Investigador del Instituto de Investigaciones Jurídicas de la Universidad Nacional Autónoma de México (UNAM). Fungió como presidente de la Sala Regional Toluca del Tribunal Electoral del Poder Judicial de la Federación. Es autor y coautor de libros, revistas y diarios especializados en materia electoral. Profesor investigador y miembro del Sistema Nacional de Investigadores Nivel II. Licenciado por la Universidad Autónoma de Querétaro y Doctor en Derecho con mención honorífica por la División de Estudios de Posgrado de la Facultad de Derecho de la UNAM. Máster Internacional en Derecho Penal, Constitución y Derechos en la Universidad Autónoma de Barcelona.
Национальные школы ХХ века - социокультурные и профессиональные парадигмы формирования архитектуры столиц. Центральноазиатский контекст
Authors: Malinovskaya Елизавета 
Published: November 2020

Обзор проектно-строительной ситуации формирования столиц Центральной Азии довольно специфичен по срав­нению с зарубежной практикой[1] в связи с особенностями местной климатической и историко-культурной ситуации. Столицами Советского Востока, начиная с 1920-х годов, становились уже существовавшие города, нередко древние, что неминуемо сказалось на концептуальной основе дея­тельности архитекторов Центра[2], задавая творческий век­тор на использование традиций. Демократическая доктри­на тех лет - культурное наследие - также ориентировала на его переосмысление, вплоть до самых ортодоксальных новаторов. Как в то время, так и в неменьшей степени позднее, в 1970-е годы приезжих архитекторов волновали и собственно творческие задачи - перспектива расширения арсенала современных приёмов и средств, использование инонациональных образцов местной традиционной культу­ры. В сходной историко-культурной и профессиональной ситуации по сравнению с деятельностью архитекторов авангарда оказался один из выдающихся мастеров мо­дернизма А.С. Косинский, в проектах по реконструкции Ташкента по существу реализовавший методологические установки советской новаторской архитектуры. Большая часть его проектов-новаций, оставшихся нереализованны­ми, подобно работам 1920-х годов, базировалась на футу­ристических идеях, как их воспринимали современники, но чью жизнеспособность доказала мировая практика конца ХХ века.
[1] Статья является продолжением материала, опубликованного в № 2 журнала «Academia. Архитектура и строительство» за 2020.
[2] Архитекторы Центра - принятое в те годы обозначение для командированных в регион.
Penggunaan Media Corong Berhitug Untuk Meningkatkan Hasil Belajar Siswa Pada Mata Pelajaran Matematika di Kelas II Sekolah Dasar Negeri 37 Pekanbaru
Authors: Iin Iin Gusmana , Haryani Mimi 
Published: November 2020

This research aimed to increase of student learning achievement through the use of CorongBerhitung mediaon Mathematics subject at the second grade of State Elementary School 37 Pekanbaru, Tampan District. This research was instigated by the low of student learning achievement that could not reach the minimum standard of passing grade determined 75. This research was a Classroom Action Research. The subjects of this research were the teachers and students, and the objects were theuse of CorongBerhitung media and learning achievement.This research was conducted for two cycles, and every cycle comprised two meetingswith several steps-planning/preparing the action, implementing, observing, and reflecting. Observation, learning achievement test, and documentation were the techniques of collecting the data. The technique of analyzing the data was Descriptive analysis that was started from obtaining, arranging, processing, presenting, and analyzing the numerical data to get the description of a symptom, event or situation.Based on the research findings, the use of CorongBerhitung media could increase student learning achievement. It was known that the mean was 55.56% before the action and it was on less than 60% interval that was on poor category. After implementing the media in the first cycle, the student learning achievement increased to 75% that was on 70%-79% interval and it was on enough category. In the second cycle, the student learning achievement increased to 100% that was on 90%-100% interval and it was on very good category. Thus, it could be concluded that the use of CorongBerhitung media could increase student learning achievementat the second grade of State Elementary School 37 Pekanbaru, Tampan District.
Emotional Contact: Terminological Problems to Use the
Phenomenon in Scientific Work and Practical Activity of the Investigator
Authors: Vartanyan Gayane Arshaluisovna 
Published: November 2020

The article problematizes the inconsistency scientific approaches to definition of “emotional contact”
at an criminalistics. The author notes that the variety and inconsistency of definitions lead to uncertainty
in the theory of research of the phenomenon and to difficulties in the practical activities of the investigator. The author justifies the necessity to clarify and correctly define the “emotional contact” with the involvement of psychologists for this purpose. The article proposes the author’s version to definition of
“emotional contact”.
The Relationship between Social Ideas about a Healthy Lifestyle
and the Level of Physical and Mental Health
Authors: Krolevets Olga Petrovna 
Published: November 2020

We studied social ideas about a healthy lifestyle, features of the quality of life and neurotic states of
respondents. The relationship between the completeness of ideas about a healthy lifestyle, on the one
hand, and mental and physical health, on the other, is revealed. The average values of quality of life indicators for a group with an unformed idea of healthy lifestyle are lower than for a group with a formed
idea of healthy lifestyle.
Successful treatment of superior sagittal sinus thrombosis after translabyrinthine resection of metastatic neuroendocrine tumor: A case report and review of literature
Authors: Wong Andrew K. , Wong Ricky H. 
Published: November 2020

Background:Postoperative cerebral venous sinus thrombosis (pCVST) after resection of cerebellopontine angle and posterior fossa tumor resections occur almost exclusively in the lateral venous sinuses and are generally asymptomatic. Thrombus extension and involvement of the superior sagittal sinus (SSS) – a serious and potentially devastating complication – are rarely described and, as such, successful treatment for which is still poorly understood. We report a case of pCVST involving the SSS after translabyrinthine approach for resection of a metastatic neuroendocrine tumor (NET), and the first that was successfully treated with anticoagulation therapy.Case Description:A 40-year-old man presented with headaches, diminished right-sided hearing, and ataxia was found to have a large right-sided cerebellopontine angle (CPA) lesion with extra-axial and possible intraparenchymal invasion. A retrosigmoid craniotomy for debulking and diagnosis was undertaken. Postoperative imaging revealed patent venous sinuses. Pathology confirmed NET. Further imaging revealed a likely pancreatic primary lesion. The patient then underwent subsequent translabyrinthine approach for definitive surgical resection. Postoperative imaging again revealed patent venous sinuses. The patient subsequently developed headaches on postoperative day 10 and was found to have pCVST involving the ipsilateral internal jugular to the SSS. The patient was started on therapeutic heparin with significant improvement in pCVST and symptoms.Conclusion:Extensive pCVST involving the SSS after CPA and posterior fossa tumor resections is extremely rare. Initial management with anticoagulation can yield promising results and should be initiated early in the clinical course unless otherwise contraindicated.
Prolonged length of stay and discharge disposition to rehabilitation facilities following single-level posterior lumbar interbody fusion for acquired spondylolisthesis
Authors: Benton Joshua Alexander , Ramos Rafael De La Garza , Gelfand Yaroslav , Krystal Jonathan D. , Yanamadala Vijay , Yassari Reza , Kinon Merritt D. 
Published: November 2020

Background:
Acquired lumbar spondylolisthesis is often treated with interbody fusion. However, few studies have evaluated predictors for prolonged length of stay (LOS) and disposition to rehabilitation facilities after posterior single-level lumbar interbody fusion for acquired spondylolisthesis.

Methods:
The American College of Surgeons National Quality Improvement Program database was queried for adults with acquired spondylolisthesis who underwent single-level lumbar interbody fusion through a posterior approach (posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion [TLIF]). We utilized multivariate logistic regression analysis to identify predictors of prolonged LOS and disposition in this patient population.

Results:
Among 2080 patients identified, 700 (33.7%) had a prolonged LOS (≥4 days), and 306 (14.7%) were discharged postoperatively to rehabilitation facilities. Predictors for prolonged LOS included: American Society of Anesthesiologist (ASA) class ≥3, anemia, prolonged operative time, perioperative blood transfusion, pneumonia, urinary tract infections, and return to the operating room. The following risk factors predicted discharge to postoperative rehabilitation facilities: age ≥65 years, male sex, ASA class ≥3, modified frailty score ≥2, perioperative blood transfusion, and prolonged LOS.

Conclusion:
Multiple partial-overlapping risk factors predicted prolonged LOS and discharge to rehabilitation facilities after single-level TLIF/PLIF performed for acquired spondylolisthesis.
Expression of alpha-synuclein gene and genes of lysosomal membrane proteins and enzymes in Parkinson’s disease associated with mutation in the GBA gene
Authors: Усенко Т.С. , Безрукова А.И. , Богданова Д.А. , Сенкевич К.А. , Кудреватых А.В. , Милюхина И.В. , Пчелина С.Н. 
Published: November 2020

Мутации в гене, кодирующем лизосомный фермент глюкоцереброзидазу (GBA), являются фактором высокого риска болезни Паркинсона (БП). Остается неясным, почему не у всех носителей мутаций в данном гене в течение жизни развивается БП. Предполагается, что дисфункция мембранных белков и ферментов лизосом может способствовать развитию БП у носителей мутаций в гене GBA. В данном исследовании была оценена экспрессия генов альфа-синуклеина и LAMP2, GLA, GALNS, SCARB2 в CD45+ клетках периферической крови у пациентов с GBA-БП, бессимптомных носителей мутаций в гене GBA (GBA-носителей), а также в у пациентов с БП и в контроле. Выявлена повышенная экспрессия гена альфа-синуклеина на фоне снижения уровня экспрессии генов мембранных белков лизосом (LAMP2, SCARB2) у пациентов с GBA-БП и GBA-носителей, что может свидетельствовать о вовлеченности этих генов в патогенез GBA-БП. Пониженная экспрессия гена LAMP2 может рассматриваться в качестве одного из триггеров развития БП у носителей мутаций в гене GBA.
Mutations in the gene GBA that are encoding the lysosomal enzyme glucocerebrosidase are the most common genetic risk factor for PD. Not every carrier of GBA mutations will develop PD. Probably the dysfunction of lysosomal enzymes and membrane proteins may contribute or protect to the development of PD among carriers of GBA mutations. In the current study LAMP2, GLA, GALNS, SCARB2 and alpha-synuclein mRNA levels in CD45+ blood cells were estimated in patients with GBA-associated PD (GBA-PD), non-manifesting GBA carriers(GBA-Carriers), PD patients and controls. This is the first report estimating LAMP2, GLA, GALNS, SCARB2 and alpha-synuclein expressions in CD45+ blood cells in GBA-PD patients and GBA-Carriers. We revealed increased SNCA expression and changing expression of lysosomal genes (LAMP2, GALNS, SCARB2) that may contribute role these genes in pathogenesis of GBA-PD. Decreased of LAMP2 may be considered as trigger of GBA-PD.
Myotonic dystrophy Rossolimo-Churchman-Steinert-Batten (clinical case)
Authors: Синельникова И.А. , Сопрунова И.В. , Николаева О.П. 
Published: November 2020

В статье представлено описание семейного случая миотонической дистрофии Россолимо-Штейнерта-Куршмана-Баттена. Диагноз подтвержден в результате ДНК-диагностики: выявлено увеличенное число копий CTG-повтора гена DMPK, ответственного за развитие миотонической дистрофии.
A family case report of Rossolimo-Steinert-Curschmann myotonic dystrophy is presented. An increased number of copies of CTG-repeats of the DMPK gene responsible for the development of MD, i.e., the diagnosis was confirmed by molecular genetic method.
Using high-throughput sequencing to diagnose causes of cerebral palsy
Authors: Удалова В.Ю. , Канивец И.В. , Пьянков Д.В. , Комарьков И.Ф. , Коростелев С.А. 
Published: November 2020

Детский церебральный паралич (ДЦП) - распространенная, клинически гетерогенная группа заболеваний, нарушающих двигательную функцию и поддержание позы. Предполагалось, что генетическую этиологию ДЦП имеют не более чем 2% пациентов. Целью данной работы является определение эффективности высокопроизводительного секвенирования для диагностики причин ДЦП. В нашем исследовании, генетическая этиология установлена у 31,8 % пациентов с ДЦП, возможная причина ДЦП выявлена у 17,5 % пациентов.
Cerebral palsy (CP) is a common, clinically heterogeneous group of disorders affecting movement and posture. It was assumed that the genetic etiology of CP does not exceed 2%. The aim of this work is to determine the effectiveness of high-throughput sequencing for diagnosing the causes of CP. In our study, a genetic etiology was found in 31.8% of patients with CP, a possible cause was identified in 17.5% of patients with CP.
Genetic testing for autistic spectrum disorders
Authors: Померанцева Е.А. , Исаев А.А. , Есакова А.П. , Поволоцкая И.В. , Денисенкова Е.В. , Ветрова Н.В. , Григорьева Ю.О. , Мусатова Е.В. 
Published: November 2020

Согласно рекомендациям Американской академии педиатрии при постановке диагноза аутизм, следует направить семью на консультацию генетика и генетическое обследование. Однако оптимальный подход к алгоритму генетического обследования при выявлении расстройства аутистического спектра еще предстоит разработать. В рамках исследования было проведено сравнение выявляемости генетических факторов аутизма различными молекулярно-генетическими тестами.
According to American Academy of Pediatrics recent guidelines, each family with a child diagnosed with autistic spectrum disorder should be reffered to a medical geneticist and offered genetic tests. However, an optimal genetic testing algorithm has yet to be developed. This study was conducted to compare abilities of different molecular-genetic methods to detect genetic factors of autistic spectrum disorders.