bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contextual Factors and Mechanisms that Influence Sustainability: A Realist Evaluation of Two Provincially Scaled Evidence-Based Initiatives
Authors: Flynn Rachel , Mrklas Kelly , Campbell Alyson , Wasylak Tracy , Scott Shannon D 
Published: November 2020

Abstract
Background: In 2012, Alberta Health Services created Strategic Clinical NetworksTM (SCNs) to develop and implement evidence-informed, clinician-led and team-delivered health system improvement in Alberta, Canada. SCNs have had several provincial successes in improving health outcomes. Little research has been done on the sustainability of these evidence-based implementation efforts.Methods: We conducted a qualitative realist evaluation using a case study approach to identify and explain the contextual factors and mechanisms perceived to influence the sustainability of two provincial SCN evidence-based interventions, a delirium intervention for Critical Care and an Appropriate Use of Antipsychotics (AUA) intervention for Senior’s Health. The context (C) + mechanism (M) = outcome (O) configurations (CMOcs) heuristic guided our research.Results: We conducted thirty realist interviews in two cases and found four important mechanisms facilitating sustainability: the use of a collaborative approach, audit & feedback, the informal leadership role, and patient stories. Informal leaders were often hands-on and influential to front-line staff. Learning collaboratives broke down professional and organizational silos and encouraged collective sharing and learning, motivating participants to continue with the intervention. Continual audit & feedback interventions motivated participants to want to perform and improve on a long-term basis, increasing the likelihood of sustainability of the two scaled, multi-component interventions. Patient stories demonstrated the interventions’ impact on patient outcomes, motivating staff to want to continue doing the intervention, and increasing the likelihood of its sustainability.Conclusions: There are important contextual factors and mechanisms within sustainability processes that may apply to systems change implementers and decision makers. Our research revealed the causal relationship between implementation and sustainability and how outcomes from implementation shape sustainability contexts. Future work is needed to evaluate the effectiveness of informal leadership, learning collaboratives, audit-feedback, and patient stories as strategies for sustainability, to generate better guidance on planning sustainable improvements with long term impact.
Treatment efficacy and tuberculosis relapses in HIV infected patients with severe immunosuppression who started antiretroviral therapy
Authors: Korzh E. V. , Podchos N. A. , Striga L. V. , Izvekova T. S. , Malyavko N. A. 
Published: November 2020

The objective: to analyze treatment efficacy and causes of tuberculosis relapses in HIV-infected patients with severe immunosuppression who have started antiretroviral therapy (ART). Subjects and methods. 139 case histories were studied, those case history belonged to the patients with TB/HIV co-infection and CD4 count below 100 cells/μl, a median of 33.2 cells/μl – 4.2%, who started ART in the in-patient unit. The efficacy of inpatient treatment was assessed; 89 patients were followed up after discharge from hospital. The follow-up period lasted from January 2011 to May 2019. Results. ART did not increase the efficacy of the in-patient stage of TB/HIV treatment due to the development of immune reconstitution inflammatory syndrome, which occurred in 34.5% of patients and accounted for 70.0% of hospital lethality cases. After discharge from hospital, 69.7% of patients successfully completed anti-tuberculosis chemotherapy, 25.8% died before completing treatment, the main cause of death was tuberculosis (56.5%), including multiple drug resistance in 30.8% of cases. At the outpatient stage, 29.1% of patients interrupted ART, their death rate was higher (p = 0.007), and tuberculosis and HIV-associated diseases became the cause of death more often (p = 0.042) versus the compliant patients. Tuberculosis relapses developed in 17.7% after 16.7 ± 1.7 months after completion of treatment; 63.6% had multiple drug resistance, patients with tuberculosis relapses interrupted ART more often (p = 0.002), had a lower CD4 count (p = 0.030) versus patients without relapses. As of May 2019, 46.1% of patients survived and had no signs of active tuberculosis; 42.7% died, tuberculosis dominated among the causes of death – 50.0% (in 52.6% – multiple drug resistance) as well as HIV-associated diseases (21.1%).
Alteration of <i>STAT3</i> gene expression in psoriasis treatment
Authors: Sobolev V. V. , Denisova E. V. , Korsunskaya I. M. 
Published: November 2020

Introduction. Psoriasis is a typical complex multigenic and multifactorial disease with heterogeneous genetic heredity, which requires the interaction of genes both with each other and with environmental factors. STAT3 (Signal Transducer and Activator of Transcription 3) has only recently been considered a key player in the development and pathogenesis of psoriasis and psoriatic inflammatory conditions.Aim of the study. To study the expression of the STAT3 gene in the affected part of the skin of psoriasis patients in relation to the visually unaffected part. To study the change in the STAT3 gene expression level in psoriasis-affected skin as compared to nonaffected skin in patients before and after treatment with low-level laser radiation at a wavelength of 1.27 pm.Materials and methods. The study involved 12 psoriasis patients. Biopsies from the unaffected skin were taken at a distance of about 3 cm from the affected skin. Real-time PCR analysis was performed.Results and discussion. The expression of the STAT3 gene was quantitatively measured using RT-PCR in the affected part of the skin of psoriasis patients compared to the visually unaffected part of the skin of the same patients before and after treatment with low-level laser radiation with a wavelength of 1.27 gm (short-wave infrared). As a result of the study, an increase in the expression of the STAT3 gene in the affected part of the skin of psoriasis patients of an average of 3.96 ± 2 times was experimentally shown. A decrease in gene expression was observed in psoriasis affected skin compared to samples of non-affected areas. After treatment of patients with low-level laser radiation, a significant reduction in the expression of the overexpressed STAT3 gene to 1.75 ± 0.5 times was observed.Conclusions. The transcription activity of the STAT3 gene can be an indicator of the efficacy of psoriasis treatment at the molecular level and can also be a new therapeutic target.
Optimizing the management of smoking patients with acute rhinosinusitis
Authors: Garashchenko T. I. , Serebryakova I. U. , Davudov K. Sh. , Korobkin A. S. 
Published: November 2020

Introduction. Viral infection is the main cause of damage to the ciliated epithelium of the nasal cavity mucosa, which in turn leads to disruption of mucociliary transport, increased viscosity and mucus hypersecretion in the sinuses and deceleration of its evacuation. Smokers suffer from chronic obstructive pulmonary diseases, in particular obstructive bronchitis. Their cough symptom complex sharply increases in acute respiratory viral infection (ARVI), especially when the mucociliary airway system is affected. The etiotropic treatment of this combined pathology is a therapy capable of affecting the entire mucociliary system of the upper and lower respiratory tract, including a drug based on ivy leaf extract, with the active ingredient of the saponin group.Aim of the study. To determine the effectiveness of phytopreparation in preventing exacerbation of chronic bronchitis of smokers in patients with acute viral rhinosinusitis.Materials and methods. Complex examination of 20 active smokers suffering from acute viral rhinosinusitis (AVR), including computed tomography of the lungs, was conducted. The randomized study included the use of phytopreparations in the complex therapy of acute rhinosinusitis in patients with obstructive bronchitis.Results and discussion. Use of medicines based on ivy extract in the complex treatment of acute rhinosinusitis in smokers allowed to achieve reduction of AVR symptom complex complicated by exacerbation of chronic bronchitis by the 5th day of the disease. Dynamics of cough complaints reduction in comparison groups reflects the beneficial effect of ivy extract in smokers with ARVI, complicated by AVR, and in the absolute majority of cases allows avoiding bacterial complications.Conclusion. The conducted study proved the effectiveness of Gedelix in the complex treatment of viral acute rhinosinusitis in smokers. In the absolute majority of cases (80% of the total number of patients in the group) it was possible to avoid long-term exacerbation of chronic bronchitis and bacterial complications.
Pharmacokinetics of a Mono-pyridinium-mono-aldoxime (K-347), a Potential Antidote in Organophosphate Poisoning
Authors: Kalász Huba , Karvaly Gellért , Szimrók Ferenc , Szabó Dóra , Milánkovits Márton , Keglevich András , Adeghate Jennifer , Darvas Ferenc , Kuca Kamil , Musilek Kamil , Tekes Kornélia 
Published: November 2020

Background:
Our recent work has been treating the pharmacokinetics of pyridinium aldoximes of various structures including their time-dependent distribution in the body of male rats and also the extent of blood-brain-barrier penetration.

Objective:
Our overall aim was to find a proper antidote in organophosphate poisoning with fast elimination.

Methods:
White male Wistar rats were intramuscularly injected with the aqueous solution of 3 µmol of K-347. The animals were sacrificed at different time periods following treatment; various tissues and body fluids were taken and homogenised. The level of K-347 was determined using reversed-phase HPLC. Dose-dependence of tissue level was also determined by using various doses, 3 µmol through 100 µmol of K-347.

Results:
The serum level of K-347 showed a definitely fast decline. K347 did not have any effect on Gram-positive and Gram-negative bacteria that we tested.

Conclusion:
The kinetics of K-347 showed an extremely fast offset, even in comparison with several other pyridinium aldoximes in clinical practice and in developmental stages.
Plano de assistência
Authors: RSP Editor 
Published: November 2020

Dois trabalhos de incalculável importância que muito credenciam a administração de pessoal no Brasil são o Plano de Classificação de Cargos e o Plano de Assistência aos ServidoresPúblicos Civis da União. Do primeiro já se sabe o que foi realizado, cabendo, no momento, ao Congresso Nacional ultimar o projeto de lei em que se consubstancia. A respeito do Plano de Assistência pouco foi divulgado. Muitas críticas têm surgido face à demora com que os estudos se processam. Emprêsa de tal envergadura não poderia,realmente, ultimar-se contando apenas com a boa intenção dos seus planejadores. Muitas etapas teriam de ser vencidas, muitas pesquisas haveriam de ser efetuadas, entre elas o levantamento real da situação existente.
Racionalização administrativa do Brasil
Authors: Estelita Campos Wagner 
Published: November 2020

Quando recebi a determinação de pronunciar uma palestra sôbre “Racionalização administrativa do Brasil” , confesso que me senti, de início, aturdidocom a responsabilidade e a extensão do tema, do mesmo passo que confundido com a honrosa generosidade da escolha de meu modesto nome, para abordar assunto que tem sido objeto, nos círculos administrativos, no Parlamento e na imprensa, da cogitação de eminentes estudiosos.
Os estudos da economia doméstica na formação da mulher rural
Authors: De Castro Belleza Newton 
Published: November 2020

Assume para nós interesse particular a difusão que sé fizer sôbre estudosde economia doméstica para que chegue a todos o conhecimento de seus objetivos,até criar-se o senso — que ainda nos falta — da responsabilidade públicae coletiva nesse campo de realizações.
Que é o serviço de documentação do MTIC?
Authors: Silveira Joel , Carlomagno Huguenin Orlando 
Published: November 2020

Qualquer serviço de documentação, seja qual tõr a amplitude de suasatividades ou os recursos técnicos e materiais de que disponha, representasempre algo de útil à cultura, à administração pública, ao progresso geral danação, enfim, sob os seus variados aspectos.
Arrecadação e fiscalização das rendas públicas federais
Authors: De Bulhões Augusto 
Published: November 2020

A transferência da Côrte Portuguesa para o Rio de Janeiro, em 1808, trouxeinestimáveis benefícios ao Brasil. Verificou-se, como por encanto o fenômeno histórico social que SílvioRomero denominou “inversão brasileira” ; passou o Brasil de Colônia a M etrópolee Portugal de Metrópole a Colônia. No primeiro Ministério de D . João no Brasil, coube a D. FernandoJosé de Portugal e Castro, depois Marquês de Aguiar, ser o Ministro dos Negóciosdo Reino, com fôrça de Primeiro Ministro, Chefe do Gabinete Ministerial.
Aspectos constitucionais das empresas de serviço público
Authors: De Medeiros Océlio 
Published: November 2020

Em se tratando dos aspectos constitucionais dos Serviços de Utilidade Pública no Brasil deve-se ter em vista, precipuamente, o complexo problema da regulamentação dêsses serviços, além da natureza e classificação dos mesmos, em face da experiência brasileira.
Des vertus de l'analyse de texte. Pour un tournant littéraire
Authors: Fröhlicher Peter 
Published: November 2020

Si toutes les sciences humaines travaillent, d’une manière ou d’une autre, sur des textes, les spécialistes de l’analyse et de l’interprétation des textes complexes sont les critiques littéraires qui, à la différence des philosophes ou des théologiens, rendent compte également des aspects formels de la langue. Définissant l’identité de notre discipline, c’est précisément cette compétence interprétative fondamentale qui pourrait se révéler fructueuse dans les coopérations transdisciplinaires. / Après les tournants linguistique, culturel ou visuel, on souhaiterait pour notre discipline, sans prétendre à en faire une science pilote, un « tournant littéraire » […], développant, sans perdre de vue les « grandes questions », ce qu’on pourrait appeler la recherche fondamentale en études littéraires, c’est-à-dire la réflexion sur l’analyse et l’interprétation des œuvres.
Récemment, à la Cafétéria des Lettres
Authors: Hunkeler Thomas 
Published: November 2020

L’un : Que voulez-vous insinuer ? / L’autre : Disons que je me pose des questions sur l’enseignement de la littérature tel qu’il est pratiqué dans nos académies. A mes yeux, voyez-vous, on n’aurait jamais dû isoler la littérature comme objet d’études. Les formes littéraires, l’histoire littéraire, les genres littéraires : c’est un peu comme si on se contentait d’étudier un catalogue de voyage dans tous ses détails sans jamais partir sur les routes. Comment voulez-vous que les jeunes s’intéressent vraiment à ce qu’ils ressentent comme un pur exercice de style, loin de leur réalité, de leur vie et de leurs rêves ?
Expressions of Children and Families on Children’s Rights: Lessons from STM: EC 2019
Authors: Batool Warda , Apostolopoulos Marina , Bagirakandi Melissa , Jayawardena Nichola Nonis , Lee Justine 
Published: November 2020

Abstract
The Shaking the Movers: Early Childhood (STM: EC) event was held at Ryerson University and was the first to invite young children to participate in learning about and discussing their inherent rights. In this article, five graduate students draw on young children’s and family members’ expressions, with regard to children’s right to non-discrimination (United Nations General Assembly, 1989, Article 2), as well as lessons learned, and their suggestions for future STM events. Children and families experiences as presented in the STM: EC report (Robichaud et al., 2019) were examined and the following themes emerged: children’s ideas and thoughts about their rights, spaces for children to learn about their rights, and adults’ views and ideas about children’s rights. The authors provide evidence on how events such as STM are beneficial in understanding children’s expressions and ideas regarding their rights, and the importance of creating spaces that foster children’s rights.
Keywords: Shaking the Movers, children’s rights, right to non-discrimination, children’s expression, early childhood education
Tren Harga Bawang Merah di Pasar Besar Kota Batu dan Pasar Sayur Karangploso Kabupaten Malang Periode Januari 2017 – Desember 2019
Authors: Habib Bahrul Muchlis , Sudibyo Rahmad Pulung 
Published: November 2020

Onions (Allium Cepa) is a vegetable that be a part of root vegetables such as carrot, potato, etc wich commonly used mainly the root part to be consumed. Onions known as one of the primary ingredient for food because it’s role as seasoning or as supplementary material like fried onions make it one of the ingredient with high economic value. Not surprisingly the price of onions commodity fluctuate everytime. Purpose of the research is : (1) knowing the onions price trend in Pasar Besar Kota Batu and Pasar Karangploso for the last 3 years (2) knowing the difference of the onions price trend between Pasar Besar Kota Batu and Pasar Karangploso. location determined intentionally (purposive). Data used for this research is secondary data obtained from Siskaperbapo or Sistem Informasi Ketersediaan dan Perkembangan Harga Bahan Pokok managed by Disperindag of East Java Province. Analysis used for this research is tabulation and chart, also least cost methode to show the trend happened also to project the possible price in the near future. The result show that the trend is tend to fluctuate annually but if we break down each month and use least cost method both location show a negatif price trend.
Kontribusi Nilai Curahan Kerja Wanita terhadap Pendapatan Rumah Tangga Petani Padi Sawah di Desa Noelbaki, Kecamatan Kupang Tengah, Kabupaten Kupang
Authors: Amheka Ana Maria , Suek Johanna , Nampa I Wayan 
Published: November 2020

This research aims to know number of women working hours in non agricultural and agricultural sectors and their role in grain farmers’ household income. The research has carried out in Noebaki Village, using 46 samples that chosen purposively based on active women.The collected data have been analyzed descriptively. Research result shows that allocation of women working time in five activities compare to men that of eight activities. Total Women time allocation for working as many as 542 HKO (11,40 HKO/person/ in a season),Total while men time allocation as many as 1.119 HKO (24,32 HKO/person/in a season) in seedling, weeding, fertilizing, transport and post harvest activities. Besides that, women are also working in non agricultural sector as a washing cloth and weaving with working times as many as 55.71 HKO and 56,77 HKO consecutively. From this job the women can contribute as much as 1.824.627 IDR or 11.15% to the household income. This contribution is smaller compare to 50% of income. Therefore to increase the women role in economic household, they have to improve their skill in various way as individual or as a group.Key Wors: Labor Outpouring Womens working Value, and , Income contribution
Effectiveness of Online Teaching During COVID-19 Pandemic for West Midlands Urology Trainees
Authors: Wong Anton 
Published: November 2020

Background and Objective Urology trainees in the West Midlands are provided with protected compulsory teaching sessions by the deanery. These teaching sessions are usually held in a regional centre, on a face-to-face basis. However, the coronavirus (COVID-19) pandemic has had a profound impact not only on individuals, the healthcare system, but has affected medical education for trainees. All regional teaching sessions have been moved online for the safety of individuals and to comply with social distancing guidelines. The aim of this study is to evaluate the effectiveness of online teaching during the pandemic. Material and Methods An online survey was sent out to all urology trainees in the West Midlands. The questionnaire, comprised of a mixture of open, closed and Likert-10-point scale questions was used to compare online teaching against face-to-face teaching. An independent t-test was carried out as the data was presumed to follow a normal distribution. Statistical significance was set at p<0.05. Results 70% of trainees responded and participated in the survey. Attendance rates were higher when teaching was online compared to face-to-face sessions. 100% of trainees were able to attend at least 80% of online teaching sessions whilst 89% were able to attend face-to-face sessions. However, the quality of teaching were not statistically significant between face-to-face and online teaching sessions (mean = 7.95 and 8.11 respectively, p= 0.316). The study found that trainees benefited from the accessibility of online teaching sessions but lost out on social networking and interactivity of face-to-face sessions. Most participants recommended a hybrid or blended learning approach once the pandemic is over. Conclusion The impact of COVID-19 has almost forced all undergraduate and postgraduate education to have a form of virtual presence. All teaching sessions will remain online for the foreseeable future. Our study found no difference between the qualities of teaching for both approaches. However, benefits and drawbacks of online teaching have been identified. Hence, we recommend a mixed learning approach of face-to-face and online teaching for the future.
COVID-19 and employment in Brazilian microregions: A spatial analysis
Authors: Stege Alysson Luiz , Pelinski Raiher Augusta , Souza do Carmos Alex Sander 
Published: November 2020

The main goal of this paper is to analyze the Covid-19 effect on jobs, using Brazilian microregions data. The Covid-19 effect was disaggregated into exogenous (reduction in exports) and endogenous (increase in social distancing) variables, the coefficient was estimated by Geographically Weighted Regression (GWR). Using this methodology we can control the extremum heterogeneity, estimating one coefficient for each microregion in the sample. The results revealed that exports did not have any effects on jobs. On the other hand, the social distancing presented negative effect on employment, besides, stronger effect was observed in the Brazilian Northeastern region.
PELATIHAN SENI PERAN (AKTING) TEATER MONOLOG BAGI SISWA-SISWI DALAM MEMPERSIAPKAN KEGIATAN FLS2N
Authors: Yalesvita Yalesvita , Eliza Meria 
Published: November 2020

Program Pengabdian Masyarakat ini bertujuan untuk membuka ruang, pengetahuan dan pembinaan bagi generasi muda (siswa-i ) SMUN 01 Batusangkar dalam mempersiapkan diri mengikuti program FLS2N di bidang seni khususnya bidang Monolog. Selain itu pengabdian ini akan menjadi wadah bagi siswa-i menyiapkan portofolio. Pengabdian masyarakat yang akan dilakukan ini, dimaksudkan memberi pelatihan bagi siswa-siswi dalam mengasah bakat dan minat trampil bermonolog, bagaimana menuturkan berbagai pilihan cerita dalam naskah. Pelatihan diawali dengan teknik/latihan dasar, metoda pelatihan bagi siswa-i dalam memerankan/menampilkan karakter. Latihan dasar berupa latihan gesture, emosional, vokal (komunikasi) dan kecerdasan intelektual. Kemudian pelatihan akan dilanjutkan tentang pelatihan pemahaman terhadap naskah dan teknik menyampaikan/ mengkomunikasikan, dan terakhir pelatihan penguasan ruang, karakter dan penonton