bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSING THE ROLE OF ARTIFICIAL INTELLIGENCE IN THE DESIGN OF DRUG DELIVERY SYSTEMS
Authors: Waheed Abdul , K Ashwin , M Hima Bindu 
Published: December 2020

Over ten years, increasing the interest has been fascinated towards the appeal of intelligent retrieval (IR) technology for data interpretation and illuminate the biological or transmitted information, speed up drug invention, and pinpointing of the selective small-molecule modulator control or rare particle and projection of their behavior. To make use of biomaterials, synthetic resin, fats, along IR is upcoming for the manufacture of drug deliverables. The request of the computerized workflows and databases for quick calculation of the vast amounts of data and artificial neural networks (ANNs) for growth of the narrative proposition and treatment schemes, forecast of disease development, and judgment of the pharmacological description of drug candidates may consequently improve treatment outcomes. Target fishing (TG) by quick projection or identification of the biological quarry might be of great help for linking quarry to the new substance.AI and TF methods in union with human knowledge may indeed transform the present-day diagnostic strategies, meanwhile verifying approaches are necessary to overcome the possible challenges and make certain higher perfection. In this review, the importance of AI and TF in the growth of drugs and transport systems and the possible challenging topics have been spotlighted.
Keywords: Artificial intelligence; biomaterials, polymers, lipids, Drug Delivery.
Model for estimating the healthcare costs and capacity of intensive care units in Italy in the treatment of patients with COVID-19: remdesivir impact assessment
Authors: Ruggeri Matteo , Signorini Alessandro , Drago Carlo , Rosiello Francesco , Marchetti Marco 
Published: December 2020

Introduction: Coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory syndrome coronavirus 2, which is a human coronavirus responsible for a pandemic. Direct interventions, i.e. physical distancing and use of protective devices, can prevent or limit contagions, however, it is also required to evaluate the optimization of limited resources, such as the Intensive Care Unit (ICU). For this purpose, it is relevant to estimate the impact of therapeutic solutions that reduce the probability that the patient transits to ICU in symptomatic subjects and in need of hospitalization. The therapeutic solutions allow a more rapid recovery of the patient and save scarce resources that can be used in the treatment of other patients.
Methods: A forecasting model is designed to estimate the impact of one therapeutic solution, i.e. the antiretroviral Remdesivir, on both the capacity of intensive care and the healthcare costs for hospitals when managing the current emergency. A base case is presented as well as a best and a worst case scenario deriving from the sensitivity analyses.
Results: The introduction of Remdesivir in patients receiving low-flow oxygen therapy with the purpose of reducing ICU accesses and deaths leads to 431 million euros cost savings and avoids 17,150 hospitalizations in intensive care and 6,923 deaths. In the best case, 294 million euros savings are estimated, whilst in the worst case the model estimates a saving of 512 million euros.
Conclusions: Remdesivir has the potential to reduce the negative effects of the Coronavirus disease, improving patient conditions and reducing death tolls, and can also save scarce healthcare resources during this pandemic, resulting in a shorter hospital stay and fewer ICU admissions. (Market Access)
БЕГУЩАЯ ПО ВОЛНАМ ВРЕМЕНИ: МОДЕЛЬ КАНОЭ ИЗ XIX в.
Authors: Лебедева Арина Александровна 
Published: December 2020

В корабельном фонде Центрального военного-морского музея хранится модель микронезийского каноэ, изготовленная в 1819 г. по чертежам, снятым непосредственно c судна островитян в ходе плавания Отто Евстафьевича Коцебу 1815–1818 гг. Этот предмет, реконструирующий доконтактный облик микронезийского каноэ, является чрезвычайно ценным источником по традиционной культуре мореплавания региона. Однако именно в таком качестве модель ранее не привлекала внимания исследователей.
В ходе проведенной работы мы, во-первых, рассмотрели исторический контекст появления предмета, что позволило провести его атрибуцию. Во-вторых, были определены конструктивные параметры модели путем проведения обмеров и создания теоретического чертежа. Данные были конвертированы в графические программы. Микронезийские каноэ – высокотехнологичные объекты традиционной культуры, в них реализованы самобытные принципы судостроения, основанные на эмпирическом использовании островитянами законов гидро- и аэродинимики, сегодня выраженных сложными формулами и уравнениями. Поэтому для «активации» исследовательского потенциала модели необходимо оперировать этими точными техническими данными. Только такой подход может обеспечить адекватный анализ конструктивных характеристик для корректной постановки и решения вопросов, связанных c мореходными возможностями каноэ. Настоящее исследование, таким образом, задумано, как первое в серии, посвященной данному предмету.

In the ship storage of the central Naval Museum there is a model of a Micronesian canoe, which dates back to the first quarter of the XIX century. The model was carved according to the scheme of Micronesian canoe that was made during the voyages of Otto von Kozebue in 1815–1818. Thus, the model is an object of exceptional value for understanding the traditional navigational culture of the region. However, the item has not been studied yet. Firstly, we attributed the model by investigating the historical context of it’s appearance in the museum collection. Then, accurate technical and constructive data were acquired by measuring of the item and making a theoretical drawing of it; the data were uploaded to digital graphic programs. Micronesian canoes are the hi-tech objects of traditional culture, which demonstrate the original shipbuilding principles, based on the empirical knowledge of physical laws of the islanders. To activate the investigative potential of the model we need to have exact technical parameters. It is the only way to analyze the constructive specifications and solve the questions of seafaring possibilities of the canoes. This publication is the first in the series, devoted to this item.
Fluconazole for Hypercortisolism in Cushing’s Disease: A Case Report and Literature Review
Authors: Zhao Yiming , Liang Weiwei , Cai Feng , Wu Qun , Wang Yongjian 
Published: December 2020

BackgroundCushing’s disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery.CaseWe report a case of a patient with Cushing’s disease and pulmonary Cryptococcus neoformans. A 48-year-old woman was admitted to our hospital because of moon face and edema. Laboratory and radiological findings suggested a diagnosis of Cushing’s disease and pulmonary cryptococcus infection. Fluconazole 400 mg per day was administered intravenously and continued orally for 3 months. Both cryptococcus infection and hypercortisolism relieved and transsphenoidal resection was performed.ConclusionCushing’s disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing’s disease patients with cryptococcal pneumonia.
Alterações Neurológicas Na Covid-19: Uma Revisão Sistemática
Authors: Nunes Maria Jussara Medeiros , Silva Jean Carlos Souza , Oliveira Lucidio Clebeson de , Marcos Gabriel Victor Teodoro de Medeiros , Fernandes Amélia Carolina Lopes , Santos Wedney Livanio de Sousa , Guzen Fausto Pierdoná , Cavalcanti José Rodolfo Lopes de Paiva , Araújo Dayane Pessoa de 
Published: December 2020

Introdução. A doença causada pelo novo SARS-CoV-2, Covid 19, possui capacidade de infectar diferentes células do corpo humano. Destarte para as células do SNC que podem ser infectadas juntamente com sistema respiratório. Estudos comprovam também a existência de sintomas neurológicos em pacientes com COVID-19. Objetivo. Revisar o material bibliográfico existente que descrevem os impactos neurológicos associados a COVID-19. Método. A estratégia de busca dos dados utilizados contou com estudos obtidos por meio de cinco bases de dados. Cada fonte de dados utilizou-se os filtros: título, assunto e tipo. O descritor Neurological foi combinado utilizando o operador booleano AND com os descritores: Coronavirus COVID-19 e Nervous System Diseases e seus correspondentes respectivos na língua portuguesa. Resultados. O Sars-cov-2 possui capacidade de neuroinvasão, assim como os outros tipos de corona vírus. A agressividade dos sintomas pode variar de sintomas mais leves até predispor a doenças cerebrovasculares agudas, em especial, nos pacientes com comorbidades (HAS eDM). Período de aparecimento dos sintomas pode ser em média 1-2 após aparecimento dos sintomas respiratórios. Em pacientes hipertensos os sintomas respiratórios podem ser amenizados, acarretando maior atenção para investigação e diagnóstico. Conclusão. Este estudo oferece novas e importantes informações clínicas sobre a COVID-19 e alterações neurológicas com alta contribuição aos profissionais da área da saúde em ampliarem o espectro de visão da doença além dos distúrbios cardiorrespiratórios, demonstrando a evolução clínica da doença para manifestações neurológicas associadas. Além de também auxiliá-los na identificação dos possíveis agravos em pacientes com COVID-19 e distúrbios neurológicos pré-existentes.
Analisis Tentang Tujuan Pendidikan Agama Kristen (PAK) Dalam Matius 28:19-20
Authors: Tanduklangi Rinaldus 
Published: December 2020

The Gospel of Matthew is a part of the new covenant the presents the great commission of the Jesus. The great commission is the command of the Lord Jesus to the disciples and to all believers in all ages. The great commission becomes the foundation in carrying out educational actions for the world in which Jesus has provided instructions, methods and ways of implementing them. The great commission becomes the foundation of education especially Christian religious education. This paper aims to analyze theologically the objectives of Christian religious education based on Matthew 28: 19-20. In an effort to trace the intention used qualitative-descriptive research methods. The results obtained that the purpose of PAK based on Matthew 28: 19-20's exposure is to make disciples of all nations, baptize and teach them to do all the commands of the Jesus.
Injl Matius merupakan salah satu bagian kitab perjanjian baru yang menyajikan amanat agung Tuhan Yesus. Amanat agung ialah perintah Tuhan Yesus bagi para murid dan kepada semua orang percaya di segala zaman. Amanat agung menjadi landasan dalam melaksanakan tindakan pendidikan bagi dunia yang di dalamnya Yesus telah memberikan petunjuk, metode dan cara pelaksanaannya. Amanat agung menjadi landasan pendidikan khususnya pendidikan agama Kristen (PAK). Tulisan ini bertujuan untuk menganalasis secara teologis tujuan pendidikan agama kristen (PAK) berdasarkan Matius 28:19-20. Dalam upaya menelusuri maksud tersebut digunakan metode penelitian kualitatif-deskriptif. Hasil yang diperoleh bahwa tujuan PAK berdasarkan paparan Matius 28:19-20 ialah memuridkan segala bangsa, membaptis dan mengajar mereka melakukan segala perintah Tuhan Yesus.
Konseling Agama Pada Siswa Pecandu Narkoba
Authors: Masing Musa 
Published: December 2020

The purpose of giving counseling for drug addicts students is to correct mistakes that are the new direction and purpose of life in God. Direction of life to God who will be equipped to a better future. In this study using qualitative research with case study techniques. The subjects in this study consisted of 2 students, junior high school students in Samarinda City who were addicted to drugs but were undergoing rehabilitation at the Tanah Merah Samarinda Rehabilitation Center and one person as a mental mentor of religion. This research focuses on Religious Counseling on addicted students. The purpose of this research is to find out the type of religious counseling used for drug addicts students who are undergoing rehabilitation at the BNN Tanah Merah Rehabilitation. The results showed that there were 6 Religious Counseling conducted at the Tanah Merah Samarinda Rehabilitation Center for DT and KS Clients, namely 6 Supportive-Counseling, Confrontational-Counseling, Educative-Counseling, Spiritual-Counseling, Group-Counseling, Preventive-Counseling.
Tujuan pemberian konseling bagi siswa pecandu narkoba adalah memperbaiki kesalahan yang menjadi arah dan tujuan hidup baru di dalam Tuhan. Pengarahan hidup kepada Tuhan yang akan menjadi bekal menuju masa depan yang lebih baik. Dalam penelitian ini menggunakan penelitian Kualitatif dengan Teknik studi kasus. Subjek dalam penelitian ini terdiri dari 2 yaitu Siswa Sekolah Menengah Pertama (SMP) di Kota Samarinda yang menjadi Pecandu narkoba tetapi sedang menjalani rehabilitasi di Balai Rehabilitasi BNN Tanah Merah Samarinda dan satu orang sebagai Pembina mental Agama. Penelitian ini menfokuskan pada Konseling Agama pada siswa pecandu. Tujuan Penelitiannya adalah untuk mengetahui jenis konseling agama yang digunakan bagi siswa pecandu narkoba yang sedang menjalani rehabilitasi di Balai Rehabilitasi BNN Tanah Merah Samarinda. Hasil penelitian menunjukkan bahwa Konseling Agama yang dilakukan di Balai Rehabilitasi BNN Tanah Merah Samarinda kepada Klien DT dan KS ada 6 yaitu Supportive-Konseling, Confrontational-Konseling, Educative-Konseling, Spiritual-Konseling, Group-Konseling, Preventive-Konseling.
Gamma-Ray Burst Triangulation with a Near-Earth Network
Authors: Hurley Kevin C. 
Published: December 2020

Abstract
We study the characteristics of near-Earth networks (NENs) of gamma-ray burst (GRB) detectors, with the objective of defining a network with all-sky, full-time localization capability for multimessenger astrophysics. We show that a minimum network consisting of nine identical spacecraft in two orbits with different inclinations provides a good combination of sky coverage with several-degree localization accuracy with detector areas of 100 cm2. In order to achieve this, careful attention must be paid to systematics. This includes accurate photon timing (∼0.1 ms), good energy resolution (∼10%), and reduction of Earth albedo, which are all within current capabilities. Such a network can be scaled in both the number and size of detectors to produce increased accuracy. We introduce a new method of localization that does not rely on on-board trigger systems or on the cross-correlation of time histories, but rather it tests positions in ground processing over the entire sky and assigns probabilities to them to detect and localize events. We demonstrate its capabilities with simulations. If the NEN spacecraft can downlink at least several hundred time- and energy-tagged events per second, and the data can be ground-processed as they are received, it can in principle derive GRB positions in near-real time over the entire sky.
SQuIGG
E Survey: Massive z ∼ 0.6 Post-starburst Galaxies Exhibit Flat Age Gradients
Authors: Setton David J. , Bezanson Rachel , Suess Katherine A. , Hunt Qiana , Greene Jenny E. , Kriek Mariska , Spilker Justin S. , Feldmann Robert , Narayanan Desika 
Published: December 2020

Abstract
We present Gemini Multi-Object Spectrograph (GMOS) integral field unit (IFU) observations of six massive (M
⋆ ≥ 1011
M
⊙) A-star dominated post-starburst galaxies at z ∼ 0.6. These galaxies are a subsample of the

Survey, which selects intermediate-redshift post-starbursts from the Sloan Digital Sky Survey spectroscopic sample (DR14) with spectral shapes that indicate they have recently shut off their primary epoch of star formation. Using Hδ

A
absorption as a proxy for stellar age, we constrain five of the galaxies to have young (∼600 Myr) light-weighted ages at all radii and find that the sample on average has flat age gradients. We examine the spatial distribution of mass-weighted properties by fitting our profiles with a toy model including a young, centrally concentrated burst superimposed on an older, extended population. We find that galaxies with flat Hδ

A
profiles are inconsistent with formation via a central secondary starburst. This implies that the mechanism responsible for shutting off this dominant episode of star formation must have done so uniformly throughout the galaxy.
Psychophysiological parameters in rosacea patients after complex therapy with Cortexin
Authors: Bobrakova Alexandra A. 
Published: December 2020

Introduction: Taking into account the influence of the psycho-emotional sphere and its disorders on the pathogenetic mechanisms of rosacea, a comparative assessment of the clinical efficacy of a standard therapy and the complex therapy using Cortexin in papulopustular rosacea patients with moderate severity and concomitant neurological pathology was performed. The therapy influence on changes in the patients’ psycho-emotional state was also studied.
Materials and methods: The study involved 216 papulopustular rosacea outpatients with moderate severity with a concomitant neurological pathology, aged 20 to 60 years. The patients were divided into 2 groups: 109 people (37 men and 72 women) in the study group, and 107 people (37 men and 70 women) in the control. All the patients received a treatment according to the ”Standard of Medical Care for Patients with Rosacea” of the Ministry of Health of the Russian Federation. The study group patients additionally received Cortexin. The study was carried out using the Zung Self-Rating Anxiety Scale (SAS), the Taylor Manifest Anxiety Scale, the Spielberger State-Trait Anxiety Inventory, and the Eysenck Personality Questionnaire.
Results and discussion: The patients showed an increase in somatic manifestations of anxiety, levels of trait and state anxiety, and neuroticism initially before the start of treatment. The inclusion of Cortexin in the rosacea treatment re­duced the somatic manifestations of anxiety more effectively than standard therapy against the background of a more considerable decrease in proportion of patients with its moderate and high levels. The severity of trait and stateanxiety, neuroticism was also significantly lower against the background of the Cortexin use than with the standard treatment.
Conclusion: The Cortexin inclusion in the rosacea pharmacotherapy against the background of a concomitant neu­rological pathology contributes to a more pronounced correction of psychophysiological parameters, reflecting the neuroticism levels, trait and state anxiety, and somatic manifestations of anxiety, compared to standard treatment.
La gestion sanitaire de l’épidémie de Covid-19 par les États : recettes communes et logiques nationales
Authors: Gay Renaud , Guillas-Cavan Kevin 
Published: December 2020

L’article propose une lecture transversale du numéro qui porte sur les mobilisations sanitaires de neuf États et de l’Union européenne face à la « première vague » de l’épidémie de Covid-19. En s’intéressant aux interventions publiques sur l’accès aux soins, les services de santé et l’industrie médicale, il montre que la plupart des États ont recours à des recettes similaires (confinement, mobilisation des hôpitaux, etc.) qui s’inscrivent cependant dans des logiques nationales liées aux configurations institutionnelles et économiques des systèmes de santé.
La mobilisation sanitaire des pouvoirs publics locaux : le cas de la ville de Wuhan
Authors: Xing-Bongioanni Jingyue , Chu Jun , Qi Xuemin 
Published: December 2020

En Chine, ce sont les gouvernements locaux, en particulier celui de la ville de Wuhan, épicentre de l’épidémie, qui ont joué un rôle clé durant la crise sanitaire. D’une part, c’est à cette échelle que les décisions importantes ont été prises ; d’autre part, la majorité des dépenses liées à la lutte contre le Covid-19, y compris les primes versées aux professionnels de santé mobilisés, a été majoritairement supportée par les gouvernements locaux. Le rôle de l’État central, sans être marginal, a consisté à coordonner la mobilisation des professionnels de santé et du matériel entre les territoires, à mobiliser l’industrie et à financer une partie limitée des dépenses liées à l’action publique. Ce régime de mobilisation des ressources, s’il a permis d’être au plus proche du terrain, pose problème en termes d’équité territoriale et de capacité d’endettement des gouvernements locaux, notamment pour les régions les plus pauvres.
Une mobilisation forte, précoce… mais insuffisante de l’État fédéral
Authors: Mellado Virginia , Trenta Arnaud 
Published: December 2020

Dès les premiers cas de Covid-19, le gouvernement fédéral argentin a pris des mesures fortes pour freiner la transmission du nouveau coronavirus et accroître les capacités des institutions sanitaires. Cette stratégie préventive a permis, dans un premier temps, de circonscrire l’épidémie à l’aire métropolitaine de Buenos Aires et de focaliser l’action de dépistage sur les quartiers populaires. Dans un second temps, la constitution fédérale de la République argentine et la fragmentation du système de santé ont limité la cohérence globale de l’action publique et favorisé l’accélération de l’épidémie de Covid-19 dans l’ensemble des provinces du pays.
Système hospitalier, assurance santé et fédéralisme étasunien à l’épreuve
Authors: Sauviat Catherine 
Published: December 2020

C’est aux États-Unis que l’épidémie de Covid-19 s’est montrée la plus meurtrière, bien que les dépenses de santé par habitant y soient les plus élevées au monde. Elle aura ainsi mis au jour de manière flagrante les apories chroniques du système de santé et de l’assurance santé (coût exorbitant, fortes inégalités d’accès, sous-financement de la santé publique, système hospitalier gouverné par des logiques de marché). Elle aura aussi révélé les revers du fédéralisme américain sous l’administration Trump, notamment sa capacité à gérer une crise sanitaire d’une telle ampleur, qui se sont illustrés tout particulièrement dans l’impéritie du leadership présidentiel.
Des fragilités du système de santé exacerbées par la crise sanitaire
Authors: Delahaie Noélie 
Published: December 2020

La survenance de la pandémie liée au Covid-19 a mis à l’épreuve le système public de santé qui se trouve déjà dans une situation critique : carence en lits d’hôpital, absence de couverture universelle pour les soins de santé primaire, forte intrication des secteurs public et privé, avec pour résultat des délais d’attente parmi les plus longs d’Europe et des inégalités d’accès aux soins. Pour tenter d’endiguer la « première vague » épidémique, les autorités misent sur des restrictions sociales et économiques, l’universalisation de l’accès aux soins primaires et la mobilisation des hôpitaux privés.
Une sous-estimation initiale du risque, puis une gestion chaotique
Authors: Freyssinet Jacques 
Published: December 2020

La sous-estimation initiale du risque engendré par la pandémie a laissé place à une gestion chaotique des étapes du confinement puis du premier déconfinement. La brutale diffusion du virus a mis en évidence les défaillances d’un système de santé soumis depuis les années 1980 à des politiques de privatisation et affaibli depuis 2010 par l’austérité budgétaire. Face à l’afflux des malades, les hôpitaux publics ont été handicapés par des sous-effectifs massifs et sont restés dépourvus, pendant de longues semaines, des équipements indispensables. Les mesures d’urgence ont certes permis de faire face, mais dans des conditions qui ont révélé l’ampleur des inégalités devant la pandémie.