bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new approach to finding effective parameters controlling the performance of multi-stage fractured horizontal wells in low-permeability heavy-oil reservoirs using RSM technique
Authors: Shirbazo Armin , Fahimpour Jalal , Aminshahidy Babak 
Published: June 2020

AbstractThe application of multi-stage fractured horizontal well (MSFHW) due to its costly operation necessitates optimization of associated fracture parameters to ensure its economic success. In comparison to significant number of studies dedicated to use of MSFHWs for shale gas reservoirs, there are only few researches available for oil systems. This study explores the optimum criteria for a number of important fracture parameters in low-permeability heavy-oil systems. For this purpose, a response surface methodology (RSM) was employed to examine the simultaneous effect of four fracture parameters, including the number of fracture stages, fracture length, fracture width and fracture conductivity, on well productivity. The evaluations were conducted on two homogeneous and heterogeneous permeability systems. The optimization of fracture parameters was also performed on an economic basis by utilizing the net present value (NPV) concept. Useful charts were also generated providing practical insights into the individual and combinational effects of fracture parameters on well performance. The results from this study demonstrated that the fracture conductivity and the number of fracture stages were, respectively, the first two important parameters controlling the well productivity for rock systems with higher permeability. However, when rock texture became tighter, the number, and to a lesser extent the length, of fractures exhibited more evident role on production improvement, especially in the case of heterogeneous reservoirs. The results also underlined the significance of economic considerations, in particular, when determining the optimum fracture length and number of fracture stages.
Correction to: Characterization of oogonia stem cells in mice by Fragilis
Authors: Sheng Xiaoyan , Tian Chenglei , Liu Linlin , Wang Lingling , Ye Xiaoying , Li Jie , Zeng Ming , Liu Lin 
Published: June 2020

In the original publication the labelling on Fig. 2A and B were incorrectly published as E7.5. The correct labelling of Fig. 2A and B should be read as E17.5 which is provided in this correction.
Supply–Demand Analysis of Urban Emergency Shelters Based on Spatiotemporal Population Estimation
Authors: Zhang Xiaodong , Yu Jia , Chen Yun , Wen Jiahong , Chen Jiayan , Yin Zhan’e 
Published: June 2020

AbstractSupply–demand analysis is an important part of the planning of urban emergency shelters. Using Pudong New Area, Shanghai, China as an example, this study estimated daytime and nighttime population of the study area based on fine-scale land use data, census data, statistical yearbook information, and Tencent user-density big data. An exponential function-based, probability density estimation method was used to analyze the spatial supply of and demand for shelters under an earthquake scenario. The results show that even if all potential available shelters are considered, they still cannot satisfy the demand of the existing population for evacuation and sheltering, especially in the northern region of Pudong, under both the daytime and the nighttime scenarios. The proposed method can reveal the spatiotemporal imbalance between shelter supply and demand. We also conducted a preliminary location selection analysis of shelters based on the supply–demand analysis results. The location selection results demonstrate the advantage of the proposed method. It can be applied to identify the areas where the supply of shelters is seriously inadequate, and provide effective decision support for the planning of urban emergency shelters.
Fracture mechanics and fatigue life assessment of box-shaped welded structures: FEM analysis and parametric design
Authors: Delkhosh E. , Khurshid M. , Barsoum I. , Barsoum Z. 
Published: June 2020

AbstractIn this study, Linear Elastic Fracture Mechanics (LEFM) approach is used to evaluate the fatigue strength of a box-shaped welded structure. A parametric study is also undertaken to study the effect of various weld parameters on the fatigue strength, such as lack of weld metal penetration, load position, and plate thicknesses. FRANC3D software was adopted to obtain the stress intensity factor values for two types of full-length and intermediate crack sizes, located at the critical region of the weld of the box-shaped structure. It was concluded that the LEFM approach could capture the crack propagation from the weld root reasonably well under the given conditions and estimate residual fatigue life of the welded structures conservatively. Compared to fatigue life estimations by nominal stress method (1,714,564 cycles) or effective notch stress method (63,385 cycles), the LEFM approach can estimate the residual life more accurately. Especially for intermediate (4 mm) lack of penetration (LOP) of weld metal case (589,198 cycles) in comparison to the experiments (1,216,595 cycles). The parametric study showed that the fatigue life increases with increase in the thickness of flanges, lesser LOP in the weld root, and when load is applied more toward the center of the plate.
Feature-Based and Adaptive Rule Adaptation in Dynamic Environments
Authors: Tabebordbar Alireza , Beheshti Amin , Benatallah Boualem , Barukh Moshe Chai 
Published: June 2020

AbstractRule-based systems have been used increasingly to augment learning algorithms for annotating data. Rules alleviate many of the shortcomings inherent in pure algorithmic approaches, in cases algorithms are not working well or lack from enough training data. However, in dynamic curation environments where data are constantly changing, there is a need to craft and adapt rules to keep them applicable and precise. Rule adaptation has been proven to be painstakingly difficult and error-prone, as an analyst is needed for examining the precision of rules and applying different modifications to adapt the imprecise ones. In this paper, we present an autonomic and conceptual approach to adapt data annotation rules. Our approach offloads analysts from adapting rules; it boosts rules to annotate a larger number of items using a set of high-level conceptual features, e.g. topic. We utilize a Bayesian multi-armed-bandit algorithm, an online learning algorithm that adapts rules based on the feedback collects from the curation environment over time. We propose a summarization technique, which offers a set of high-level conceptual features for annotating items by identifying the semantical relationships among them. We conduct experiments on different curation domains and compare the performance of our approach with systems relying on analysts for adapting rules. The experimental results show that our approach has a comparative performance to analysts in adapting rules.
Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis
Authors: Herman Bianka Edina , Gardi János , Julesz János , Tömböly Csaba , Szánti-Pintér Eszter , Fehér Klaudia , Skoda-Földes Rita , Szécsi Mihály 
Published: June 2020

AbstractThe potential inhibitory effect of diverse triazolyl-ferrocene steroids on key enzymes of the estrogen biosynthesis was investigated. Test compounds were synthesized via copper-catalyzed cycloaddition of steroidal azides and ferrocenyl-alkynes using our efficient methodology published previously. Inhibition of human aromatase, steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities was investigated with in vitro radiosubstrate incubations. Some of the test compounds were found to be potent inhibitors of the STS. A compound bearing ferrocenyl side chain on the C-2 displayed a reversible inhibition, whereas C-16 and C-17 derivatives displayed competitive irreversible binding mechanism toward the enzyme. 17α-Triazolyl-ferrocene derivatives of 17β-estradiol exerted outstanding inhibitory effect and experiments demonstrated a key role of the ferrocenyl moiety in the enhanced binding affinity. Submicromolar IC50andKiparameters enroll these compounds to the group of the most effective STS inhibitors published so far. STS inhibitory potential of the steroidal ferrocenes may lead to the development of novel compounds able to suppress in situ biosynthesis of 17β-estradiol in target tissues.
Long-term outcomes of innovator versus generic melphalan formulation in autologous hematopoietic cell transplantation for multiple myeloma
Authors: Lad Deepesh P. , Malhotra Pankaj , Patil Amol N. , Nampoothiri Ram V. , Kasudhan Kripa Shanker , Khadwal Alka , Prakash Gaurav , Jain Arihant , Malhotra Samir , Varma Neelam , Attri Savita Verma , Varma Subhash 
Published: June 2020

Background:
Most data on autologous hematopoietic cell transplantation (auto-HCT) in myeloma are based on the use of innovator formulation of melphalan. Comparative bioequivalence and efficacy studies of generic melphalan are lacking.

Methods:
In this retrospective study, we report long-term outcomes of auto-HCT in myeloma using innovator (Alkeran, Aspen Pharma; n = 41) and generic melphalan (Alkacel, Celon Labs, India; n = 55) formulations. All consecutive patients at a single center from the period 2011–2018 were included.

Results:
The median follow-up in the innovator and generic groups was 61.7 and 32.5 months, respectively. Both groups were matched for age, sex, stage, and myeloma response. There were significantly more patients in the innovator melphalan group who were administered mel- phalan at a reduced dose at physician discretion (26.8% vs. 3.6%, p = .001). There were significantly more patients with grade 3 or higher mucositis (68.3% vs. 38.1%, p < .0001) and grade 3 or higher diarrhea (85.4% vs. 50.1%, p < .0001) in the innovator group. The median duration of hospital stay was significantly longer in the innovator group (19 days vs. 15.5 days, p < .0001). There were significantly more patients in the generic group who received standard maintenance (94.5% vs. 34.1%, p < .0001). Despite the differences in the melphalan dose and post-transplant strategies, the 4-year progression-free survival and overall survival were not significantly different in the two groups (58% vs. 63%, p = .7, 71% vs. 72%, p = .4, respectively).

Conclusion:
Long-term efficacy comparison is helpful in the absence of postmarketing bioequivalence studies of generic melphalan.
Colonial Education and Women’s Political Behavior in Ghana and Senegal
Authors: Hern Erin A. 
Published: June 2020

AbstractDuring Africa’s anti-colonial movements, women in French colonies were less politically active than women in British colonies. Hern examines how differences in British and French education policies in the Gold Coast and Senegal between the 1920s and the 1950s shaped women’s opportunities for participating in nationalist activity and becoming involved in early-independence politics. Compared to girls’ education in Senegal, girls’ education in the Gold Coast was more widespread, came from a variety of providers, and was less focused on domesticity. Women in the Gold Coast were thus more likely to be mobilized as political agents during the nationalist movement and integrated into Ghana’s new independent government.
COVID-19 and Psychological Disaster Preparedness – An Unmet Need
Authors: Agarwal Vishwesh , Sharma Supriya , Gupta Latika , Misra Durga Prasanna , Davalbhakta Samira , Agarwal Vikas , Goel Ashish , Aggarwal Shelley 
Published: June 2020

ABSTRACTObjective:The coronavirus disease (COVID-19) pandemic is a disaster of unprecedented proportions with global repercussions. Psychological preparedness, the primed cognitive awareness and anticipation of dealing with emotional responses in an adverse situation, has assumed a compelling relevance during a health disaster of this magnitude.Methods:An anonymized eSurvey was conducted in India to assess psychological preparedness toward the ongoing pandemic with a focus on knowledge, management of own and others’ emotional response, and anticipatory coping mechanisms among the survey population. An adapted version of the qualitative Psychological Preparedness for Natural Disaster Scale validated by the World Health Organization was widely circulated over the Internet and various social media platforms for assessment. Results are expressed as median ± standard deviation. Descriptive statistics were used and figures downloaded from surveymonkey.com.Results:Of the 1120 respondents (M:F 1.7:1, age 35 years ±14.1), most expressed a high level of perceived knowledge and confidence of managing COVID-19, such as awareness of the symptoms of the illness (95.1%), actions needed (94.4%), hospital to report to (88.9%), and emergency contact number (89.1%). A majority (95%) monitored regularly the news bulletins and scientific journals regarding COVID-19. However, nearly one-third (29.2%) could not assess their likelihood of developing COVID-19, and 17.5% were unaware of the difference between a mild and severe infection. Twenty-three percent (23.3%) were unfamiliar with the materials needed in an acute illness situation.Conclusion:Psychological disaster preparedness is reasonable, although lacking in specific domains. Timely but focused interventions can be a cost-efficient administrative exercise, which federal agencies may prioritize working on.
The impact of methodological decisions on climate reconstructions using WA-PLS
Authors: Turner Mark G. , Wei Dongyang , Prentice Iain Colin , Harrison Sandy P. 
Published: June 2020

AbstractMost techniques for pollen-based quantitative climate reconstruction use modern assemblages as a reference data set. We examine the implication of methodological choices in the selection and treatment of the reference data set for climate reconstructions using Weighted Averaging Partial Least Squares (WA-PLS) regression and records of the last glacial period from Europe. We show that the training data set used is important because it determines the climate space sampled. The range and continuity of sampling along the climate gradient is more important than sampling density. Reconstruction uncertainties are generally reduced when more taxa are included, but combining related taxa that are poorly sampled in the data set to a higher taxonomic level provides more stable reconstructions. Excluding taxa that are climatically insensitive, or systematically overrepresented in fossil pollen assemblages because of known biases in pollen production or transport, makes no significant difference to the reconstructions. However, the exclusion of taxa overrepresented because of preservation issues does produce an improvement. These findings are relevant not only for WA-PLS reconstructions but also for similar approaches using modern assemblage reference data. There is no universal solution to these issues, but we propose a number of checks to evaluate the robustness of pollen-based reconstructions.
Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study
Authors: Crum Kathleen I. , Hwang Soonjo , Blair Karina S. , Aloi Joseph M. , Meffert Harma , White Stuart F. , Tyler Patrick M. , Leibenluft Ellen , Pope Kayla , Blair R. J. R. 
Published: June 2020

AbstractBackgroundIrritability and anxiety frequently co-occur in pediatric populations. Studies separately looking at the neural correlates of these symptoms have identified engagement of similar neural systems – particularly those implicated in emotional processing. Both irritability and anxiety can be considered negative valence emotional states that might relate to emotion dysregulation. However, previous work has not examined the neural responding during the performance of an emotion regulation task as a function of interaction between irritability and anxiety simultaneously.MethodsThis fMRI study involved 155 participants (90 with significant psychopathologies and 92 male) who performed the Affective Stroop Task, designed to engage emotion regulation as a function of task demands. The Affective Reactivity Index (ARI) was used to index irritability and the Screen for Child Anxiety Related Emotional Disorders (SCARED) was used to index anxiety.ResultsLevels of irritability, but not anxiety, was positively correlated with responses to visual images within the right rostro-medial prefrontal cortex and left anterior cingulate cortex during view trials. The second region of ventral anterior cingulate cortex showed a condition-by-emotion-by-ARI score-by-SCARED score interaction. Specifically, anxiety level was significantly correlated with a decreased differential BOLD response to negative relative to neutral view trials but only in the presence of relatively high irritability.ConclusionsAtypical maintenance of emotional stimuli within the rostro-medial prefrontal cortex may exacerbate the difficulties faced by adolescents with irritability. Moreover, increased anxiety combined with significant irritability may disrupt an automatic emotional conflict-based form of emotion regulation that is particularly associated with the ventral anterior cingulate cortex.
Direct Evidence for Fluid Pressure, Dilatancy, and Compaction Affecting Slip in Isolated Faults
Authors: Proctor B. , Lockner D. A. , Kilgore B. D. , Mitchell T. M. , Beeler N. M. 
Published: June 2020

AbstractEarthquake instability occurs as a result of strength loss during sliding on a fault. It has been known for over 50 years that fault compaction or dilatancy may cause significant weakening or strengthening by dramatically changing the fluid pressure trapped in faults. Despite this fundamental importance, we have no real understanding of the exact conditions that lead to compaction or dilation during nucleation or rupture. To date, no direct measurements of pore pressure changes during slip in hydraulically isolated faults have been reported. We show direct examples of fluid pressure variations during nucleation and rupture using a miniature pressure transducer embedded in an experimental fault. We demonstrate that fluids not only are significant in controlling fault behavior but can provide the dominant mechanism controlling fault stability. The effect of fluid pressure changes can exceed frictional variations predicted by rate‐ and state‐dependent friction laws, exerting fundamental controls on earthquake rupture initiation.
Increased Mixing and Turbulence in the Wake of Offshore Wind Farm Foundations
Authors: Schultze L. K. P. , Merckelbach L. M. , Horstmann J. , Raasch S. , Carpenter J. R. 
Published: June 2020

AbstractThe addition of offshore wind farms (OWFs) to stratified regions of shelf seas poses an anthropogenic source of turbulence, in which the foundation structures remove power from the oceanic flow that is fed into turbulent mixing in the wake downstream. The loss of stratification within the wake of a single OWF structure is observed for the first time by means of field observations, which enable a qualitative characterization of the disturbed flow downstream. These results are complemented with high‐resolution large eddy simulations of four different stratification strengths that allow for a quantification of turbulence and mixing quantities in the wake of a foundation structure. The turbulent wake of a structure is narrow and highly energetic within the first 100 m, with the dissipation of turbulent kinetic energy well above background levels downstream of the structure. A single monopile is responsible for 7–10% additional mixing to that of the bottom mixed layer, whereby ∼10% of the turbulent kinetic energy generated by the structure is used in mixing. Although the effect of a single turbine on stratification is relatively low, large‐scale OWFs could significantly affect the vertical structure of a weakly stratified water column. Further, rough estimates show that the rate of formation of stratification in the study area is of the same order of magnitude as the additional mixing promoted by the structures, thus OWFs could modify the stratification regime and water column dynamics on a seasonal scale, depending on local conditions and farm geometries.
Evaluation of Different Roof Materials for the Mitigation of Urban Warming in a Subtropical Monsoon Climate
Authors: Chen Xing , Jeong Sujong , Zheng Yi , Park Hoonyoung , Park Chang‐Eui , Joo Jaewon , Choi Woosuk , Chen Xuan , Zheng Chunmiao 
Published: June 2020

AbstractDifferent roof materials are deployed for mitigating the urban heat, which significantly affects our life. However, the answer to the question of which roof material has the best cooling performance in urban areas remains uncertain. We need to compare different roof materials together under a certain climate condition to find geographically appropriate mitigation strategies. This study performs field experiments using four different roof materials (gray, white, and grass surfaces, and rooftop solar panel) to evaluate their effectiveness on temperature reductions in a subtropical monsoon climate region from December 2017 to July 2018. The results show that the white surface reduced the average daily surface temperature by 3.37 °C. This cooling effect increased with the increase in surface albedo and incoming solar radiation. On the other hand, the average cooling effect of the grass surface was much lower (0.43 °C). This is attributable to the low soil moisture, which was influenced by the monsoon, thereby indicating that the adoption of grass roofs requires consideration of the availability of water resources even in humid regions. The solar panel reduced the daily surface temperature by 0.59 °C but exerted strong warming effect (7.36 °C) during midday and cooling effect (4.03 °C) during midnight because of its low albedo, low emissivity, and low heat capacity. Our results suggest that the grass roof with a native plant species is still not comparable with the white roof for mitigating urban heat in a subtropical monsoon climate under the present climatic conditions and especially for drier climates predicted for the future, and rooftop solar panels may heat the urban atmosphere by their warm surface during daytime.
Arctic Observations Identify Phytoplankton Community Composition as Driver of Carbon Flux Attenuation
Authors: Wiedmann I. , Ceballos‐Romero E. , Villa‐Alfageme M. , Renner A. H. H. , Dybwad C. , van der Jagt H. , Svensen C. , Assmy P. , Wiktor J. M. , Tatarek A. , Różańska‐Pluta M. , Iversen M. H. 
Published: June 2020

AbstractThe attenuation coefficient b is one of the most common ways to describe how strong the carbon flux is attenuated throughout the water column. Therefore, b is an essential input variable in many carbon flux and climate models. Marsay et al. (2015, https://doi.org/10.1073/pnas.1415311112) proposed that the median surface water temperature (0–500 m) may be a predictor of b, but our observations from Arctic waters challenge this hypothesis. We found a highly variable attenuation coefficient (b = 0.43–1.84) in cold Arctic waters (<4.1 °C). Accordingly, we suggest that water temperature is not a globally valid predictor of the attenuation coefficient. We advocate instead that the phytoplankton composition and especially the relative abundance of diatoms can be used to parametrize the carbon flux attenuation in local and global carbon flux models.