bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of short- and long-term outcomes between isolated and concomitant tricuspid valve surgery
Authors: Arafat Amr A. , Alghosoon Haneen , Alghamdi Rawan , Albabtain Monirah A. , Ismail Huda , Adam Adam I. , Pragliola Claudio , Alotaibi Khaled A. 
Published: December 2024

Abstract
Background
Accurate reflections of long-term outcomes of isolated tricuspid valve surgery are underreported in the literature. Most published cohort studies consisted of patients receiving tricuspid valve surgery concomitant with left-sided procedures. Patients who undergo isolated tricuspid valve surgery usually present late for surgery, with deteriorating risk factors leading to increased surgical risk. Thus, this study aimed to compare the short- and long-term outcomes of isolated tricuspid valve surgery with those of tricuspid surgery concomitant with left-sided valve procedures. This retrospective cohort study included 617 patients who underwent isolated and left-sided concomitant tricuspid valve surgery from 2009 to 2020. We grouped the patients into isolated (n = 63) vs. concomitant tricuspid surgery (n = 554).

Results
Isolated tricuspid surgery was associated with significantly greater rates of operative mortality (19% vs. 5.2%, P < 0.001), renal failure requiring dialysis (12.7% vs. 2.71%, P < 0.001), and need for ventilation > 24 h (22.22% vs. 12.27%, P = 0.028). ICU (3 days vs. 2 days, P = 0.005) and hospital stays (13 days vs. 11 days, P = 0.042) were significantly longer in isolated tricuspid surgery patients. Isolated tricuspid surgery independently predicted hospital mortality (OR: 4.00 (95% CI: 1.59–10.05), P = 0.003). The risk of follow-up mortality was higher in patients with isolated surgery (HR: 1.95 (95% CI: 0.98–3.86); P = 0.055). However, isolated tricuspid surgery was not associated with heart failure rehospitalization (HR: 1.11 (95% CI: 0.51–2.41); P = 0.798) or increased tricuspid valve reinterventions (HR: 1.42 (95% CI: 0.51– 3.92); P = 0.499).

Conclusions
Isolated tricuspid surgery independently predicted hospital mortality and was associated with nonsignificantly higher long-term mortality. This finding highlights the importance of timely referral and intervention for patients with isolated tricuspid valve disease to optimize short- and long-term outcomes.
Global non-equilibrium thermodynamics for steady states like never before
Authors: Holyst R. , Giżyński K. , Maciołek A. , Makuch K. , Wróbel J. , Żuk P. J. 
Published: December 2024

Abstract
In this Perspective article, we introduce a new framework for the global non-equilibrium thermodynamics of stationary states. This theory uses the spatial distributions of temperature, density, velocity, and other variables in stationary states as its input. It outputs the global state parameters to describe the system's energy exchange with the environment. The number of state parameters is determined solely by the type of substance in the system and external potentials, regardless of the number of boundary conditions, fluxes within the system, or its specific geometry. The theory offers a second law of non-equilibrium thermodynamics for stationary states, predicting the direction of spontaneous processes between them. When all macroscopic fluxes reach zero, the theory reduces to equilibrium thermodynamics.
Approach to the Patient With Cyclical Cushing Syndrome
Authors: Ferriere Amandine , Nunes Marie-Laure , Tabarin Antoine 
Published: December 2024

Abstract
Cyclical Cushing syndrome (CS) is a subentity of CS, characterized by repeated episodes of excess cortisol (peaks) followed by spontaneous periods of normal or low cortisol secretion (troughs). Although considered rare, its prevalence reaches 70 of 514 to 91 of 514 (14%-18%) in patients with CS according to its definition in some reported series and can concern all etiologies of CS. Physicians should be alert to the presence of cyclical CS in patients with fluctuating symptoms or where the results of biochemical investigations indicate eucortisolism or hypocortisolism in patients with clinical CS. Cyclicity leads to difficulties in establishing the diagnosis of CS and discovering its etiology, since patients may have paradoxical/aberrant results in biochemical investigations, including inferior petrosal sinus sampling. Similarly, cyclicity complicates the interpretation of therapeutic outcomes and interferes with medical treatments for CS. Apart from cyclicity, variability of hypercortisolism is a more common phenomenon seen in CS but can cause similar problems. Since the pathophysiology and molecular basis of cyclical CS are largely unknown, a marked variability in cortisol secretion can be considered as representing a milder aspect of cyclicity within the same continuum. In this issue of “Approach to the patient,” the characteristics, main diagnostic and therapeutic pitfalls, as well as strategies for diagnosing and managing cyclicity and marked variability in CS, are discussed from the clinician's perspective using 3 clinical cases.
Clinical and Molecular Genetic Characteristics of Patients with Hereditary Hypophosphatemia
Authors: Eltan Mehmet , Alavanda Ceren , Yavas Abali Zehra , Gurpinar Tosun Busra , Kurt Ilknur , Kirkgoz Tarik , Guven Sercin , Kaygusuz Sare Betul , Abali Saygin , Helvacioglu Didem , Guran Tulay , Gokce Ibrahim , Arman Ahmet , Bereket Abdullah , Ata Pinar , Turan Serap 
Published: December 2024

Abstract

Context
Hereditary hypophosphatemia (HH), is a rare condition related to decreased renal tubular phosphate reabsorption. Although X-linked hypophosphatemia or PHEX gene variant is the most frequent cause of HH, recent advances in next-generation sequencing (NGS) techniques enable the identification of genetic etiologies as a whole.

Objective
This work aimed to identify genetic causes of HH using various genetic testing methods and to compare clinical features between FGF23-dependent and FGF23-independent HH groups.

Methods
Fifty patients (24 males) from 39 unrelated families were included. Based on initial evaluation, PHEX gene sequencing was performed in patients with clinical and biochemical findings suggestive of FGF23-dependent HH. If sequencing showed no alterations, multiplex ligation-dependent probe amplification (MLPA) analysis for PHEX was conducted. Initially, a specific gene panel was performed for FGF23-independent HH or those in whom the PHEX gene showed no genetic alteration.

Results
Genetic etiology was revealed in 43 patients from 33 families. PHEX gene variants (4 novel) were identified in 24 patients from 19 unrelated families (50%). SLC34A3 was the second most common (16.6%) and the rest were rarer causes of hypophosphatemia (DMP1 n = 3, SLC34A1 n = 2, CLCN5 n = 2, OCRL n = 2, FAM20C n = 1, SLC2A2 n = 1). When the genetically proven FGF23-dependent (n = 28) and FGF23-independent (n = 15) HH groups were compared for clinical and biochemical features; lower phosphate and TmP/GFR SDSs and higher ALP SDS with more severe clinical rickets were detected in FGF23-dependent group, whereas higher serum and urine calcium and lower PTH levels were detected in FGF23-independent group.

Conclusion
The application of MLPA provided an additional explanatory value of 10% to the molecular etiology. However, 10% of the cases of HH still remain unexplained even after a comprehensive genetic work-up. Biochemical findings suggest distinct biochemical profiles between FGF23-dependent and FGF23-independent HH groups.
Artificial light at night impairs visual lateralisation in a fish
Authors: De Russi Gaia , Bertolucci Cristiano , Lucon-Xiccato Tyrone 
Published: December 2024

ABSTRACT
Environmental light, particularly during early development, significantly influences lateralisation, the asymmetric information processing between brain hemispheres. We hypothesised that lateralisation could be affected by artificial light at night (ALAN), a widespread form of environmental pollution. In our experiment, we exposed eggs and larvae of zebrafish to either control or ALAN conditions and then tested them in a rotational test to assess motor lateralisation, and a mirror test to assess lateralisation in response to visual stimuli. The control group exhibited a significant lateralisation bias at the population level, prioritising the processing of visual information with their right hemisphere. In contrast, the zebrafish exposed to ALAN did not show this bias, leading to a notable reduction in lateralisation. Additionally, we found evidence of reduced individual differences in lateralisation in the ALAN group. Overall, our findings demonstrate that ALAN disrupts the natural lateralisation in fish larvae, possibly affecting their behaviour and survival.
A Razão prática da colegialidade no Supremo Tribunal Federal e os princípios da democracia deliberativa
Authors: Soares Chiara de Sousa Costa , Pinheiro Victor Sales 
Published: December 2024

Contextualização: As práticas interativas de um órgão colegiado como o Supremo Tribunal Federal afetam diretamente a qualidade e a legitimidade das decisões proferidas, no que concerne tanto à epistemologia dos arranjos institucionais adotados quanto à qualidade da cognoscibilidade do conteúdo deliberado.
Objetivo: O foco deste artigo é o papel do diálogo e da colegialidade, pois pretende contribuir para a reflexão sobre a importância do diálogo no Supremo Tribunal Federal, cujas decisões devem traduzir o consenso alcançado pela instituição por meio da razão prática, adequado ao modelo democrático brasileiro.
Método: Este trabalho tomou por base pesquisas nas quais se expõe a opinião dos próprios ministros acerca das práticas de diálogo dentro do Supremo, examinadas à luz do conceito de democracia deliberativa, modelo político adotado pela Constituição brasileira de 1988. Trata-se de pesquisa bibliográfica.
Resultados: O tipo de experiência deliberativa praticada na Suprema Corte implica o desfazimento do caráter colegiado da Instituição, que é substituído pelo aspecto individualista dos julgadores, o que traz prejuízo à qualidade das suas decisões judiciais, reduzindo-as mais a opiniões pessoais, minimizando a expressão da racionalidade prática daquela instituição.
Conclusões: Defende-se a hipótese de que é necessário assumir o desafio do diálogo autêntico como razão prática de um empreendimento coletivo relevante para refletir um consenso institucional, porque essa é uma perspectiva fundamental para a legitimidade das decisões de um Tribunal Colegiado.
How Product Display Orientation Affects Customers’ Choice Satisfaction in Online Purchase: A Choice Closure Perspective
Authors: Jia Yanli , Fang Yulin , Ouyang Jun 
Published: December 2024

Practice- and Policy-oriented Abstract Research Spotlights The current research offers practical guidance for e-commerce websites on effectively displaying products to improve customer satisfaction with their choices and reduce order cancellations, a challenge that has long perplexed online retailers. Specifically, a horizontal (versus vertical) display of comparable products on an e-commerce website is more positively related to customer choice satisfaction by promoting a higher level of choice closure. Our findings suggest that if e-commerce platforms are designing a new interface, they may consider adopting a horizontal display as a beneficial starting point. However, when a vertical design has been adopted for certain reasons, online retailers can incorporate cues of finality (e.g., putting a “the end” mark at the end of a product display) to help customers finalize their choices and achieve choice satisfaction, thereby mitigating potential downsides associated with vertical display layouts.
Dyadic loneliness and kidney functioning among older couples in Europe
Authors: Stokes Jeffrey E. , Jessee Lisa , Luchetti Martina , Sutin Angelina R. 
Published: December 2024

Loneliness is a growing public health concern among the ageing population. Increasingly, scholars have recognised that even married and partnered persons experience loneliness and that loneliness is associated with the health and wellbeing of both partners. Prior research has linked individual loneliness with impaired kidney functioning, but to date no study has explored dyadic associations of both one’s own and a partner’s loneliness with biological measures of kidney function. This study uses dyadic data from the 2015 wave of the Survey of Health, Ageing and Retirement in Europe (SHARE; n = 10,139 individuals from 5,290 couples) to examine associations of both partners’ loneliness with Cystatin C, a blood-based biomarker of kidney function, in a large sample of midlife and older couples in Europe. Multilevel models analysed dyadic data, wherein individuals were nested within couples. Results indicated that both individuals’ own reports of loneliness and their partners’ reports of loneliness were uniquely associated with higher Cystatin C levels. This extends prior research on dyadic loneliness and cardiovascular biomeasures, suggesting Cystatin C may be a physiological pathway for long-term health effects of loneliness – for oneself and a partner. These findings suggest that both being lonely and having a lonely partner may be risk factors for poorer kidney function, which could have implications for the overall health of both partners. We discuss implications of these findings for theory and future research and suggest Cystatin C as a potential biological pathway for harmful effects of dyadic loneliness on health among ageing couples.
Flexible PTFE hollow dielectric waveguides for terahertz applications: analysis and experimental study
Authors: Li Hao , Zhang Dehai 
Published: December 2024

In recent years, terahertz technology has developed rapidly, and one of the important topics is low-loss, flexible, and low-cost terahertz waveguides. In this paper, PTFE tubes are used as hollow terahertz dielectric waveguides with an operating frequency of up to 500 GHz. Using numerical analysis and simulation, transmission properties such as transmission loss and bending loss are discussed. In particular, special attention is given to the impact of deformation caused by compression during use on transmission performance. To validate our analysis, we fabricated PTFE tubes with an inner diameter of 0.3 mm and an outer diameter of 0.6 mm as well as the corresponding mode converters, which were measured in the 325–500 GHz frequency range. The measured transmission loss was less than 16.6 dB/m, and the bending loss was less than 2 dB/Turn.
Progression of the leprosy reaction and nerve damage: A prospective cohort study in children with leprosy from the Brazilian Amazon
Authors: Bandeira Sabrina Sampaio , dos Anjos Andressa Bocalon , Pires Carla Avelar , Quaresma Juarez Antonio Simões 
Published: December 2024

Introduction
Leprosy reactions being closely related to damage to peripheral nerves and physical disabilities associated with disease progression. Disabilities in childhood can have a devastating effect with impaired children’s cognitive, emotional, social, and educational development. We followed up the progression of leprosy reactions in children identifying associated factors with the emergence and/or worsening of nerve damage.

Materials and methods
A prospective longitudinal cohort study was performed in patients under 15 years of age affected by leprosy reactions diagnosed at the Leprosy referral unit in the Amazon region of Brazil. The follow-up time was a cohort for 2 years from diagnosis. A clinical evaluation and the simplified neurological were performed at diagnosis and every 6 months, until the end of the follow-up period.

Principal findings
Of the 77 children monitored, 38 had reactions and were recruited. Only 23.7% (9/38) of patients improved their initial neurological impairment and 42.1% (16/38) had progression of the leprosy reaction with worsening of the initial nerve damage. Two or more reaction episodes, nerve damage and two or more nerves affected at diagnosis, isolated neuritis, silent neuritis and low educational level of caregiver had a significant association with the emergence and/or worsening of neural damage.

Conclusions
A high proportion of children had progression of the leprosy reaction with worsening neural damage. The absence of warning signs of inflammation, such as pain and exacerbation of skin lesions, appears to contribute to the worse prognosis of reactions. Early diagnosis, systematic monitoring especially of neural function, beyond the educate caregivers to recognize the reactional episode early and to helping with children’s self-care are very important measures to minimize the emergence or worsening of neural damage resulting from leprosy reactions.
A comprehensive scoping review of intergenerational dance programmes for cohorts with a generational gap
Authors: O’Reilly Siobhán , Ní Bhriain Orfhlaith , Dillon Sarah , Clifford Amanda M. 
Published: December 2024

Introduction
Loneliness and physical inactivity are issues that affect both young people and older adults. This can have negative health outcomes and well as high costs on health services. Physical activity can positively influence both physical and psychosocial health outcomes, however enjoyment is necessary for adherence. Combining exercise with arts-based activities can improve enjoyment for older adults and young people. Dance has been found to be a safe and enjoyable form of physical activity that can be equally or more effective than conventional exercise options. Intergenerational interventions can improve relationships between generations. The aim of this scoping review was to collate and map the available evidence for intergenerational dance.

Methods
This scoping review followed the guidance outlined by the Joanna Briggs Institute. A systematic search of nine multidisciplinary databases and four repositories was conducted. Inclusion criteria were intergenerational dance or movement to music programmes. Exclusion criteria included dance movement therapy or groups with less than one generational gap. Data were extracted and summarised using narrative synthesis and research papers were appraised using the Mixed Methods Appraisal Tool.

Results
The search identified eleven research studies, seven expert opinion/practice expertise and 13 sources from the grey literature. Dance classes were typically 11–12 weeks long. Genres varied with some programmes including co-creation through choreography. Experiences and social outcomes were the most assessed outcomes, with a lack of studies examining physical outcomes. Participants reported enjoying the programmes stating they felt proud for taking part and looked forward to sessions. The term intergenerational was not defined in any paper.

Conclusions
Intergenerational dance is an emerging area of research. Many programmes run in communities but are not researched, therefore several gaps remain. More large-scale trials are needed around intergenerational dance. Definitions and descriptions of dance and intergenerational activity should be considered in future studies to ensure consistency.
Advancing inclusive research calculator for oncology disease areas: A resource to support the development of enrollment targets in diversity action plans for industry sponsors
Authors: Press David J. , James Spencer L. , Jolain Bruno , Richie Nicole 
Published: December 2024

Background
The Food and Drug Omnibus Report Act, signed into law in 2022, requires industry sponsors to include diversity action plans in clinical study protocols. Defining reliable methodology for measures and benchmarks is critical to ensuring adequate and consistent representation of historically underrepresented patient populations in clinical trials.

Methods
We provide an Advancing Inclusive Research (AIR) Calculator, summary tables, and data query bank to support target setting for the development of diversity action plans and to take steps toward defining enrollment standards. The AIR Calculator uses data from the US Cancer Statistics database, which covers 100% of the US population. The database provides descriptive statistics for people diagnosed with 26 different cancers from 2015–2019 by cancer site, age at diagnosis, sex, and race and ethnicity, all stratified by stage at diagnosis (early, de novo metastatic, and combined). Descriptive characteristics include frequency counts, age-adjusted incidence rates, incidence rate ratios, and 95% CIs. Robustness test results are available in the data query bank by year of diagnosis.

Results
This resource offers insights into distributions of cancer in the US. The AIR Calculator allows users to calculate representative clinical study distributions based on the sponsor-designated study size.

Discussion
The AIR Calculator serves as a valuable resource for planning of clinical studies, but additional data analyses are necessary for a comprehensive understanding at the study level. Comprehensive data collection and alignment across industry are essential to ensure consistent, accurate, and transparent benchmarks in historically underrepresented patient populations and to track progress toward the goal of improving their representation in clinical research.
Architectures of varying power
Authors: Murray Shaun 
Published: December 2024

As buildings need bodies, architectural design needs new modalities in unpacking space making and habitation. Space making and habitation have often been studied whole in space but never whole in time, while spaces adapt best when constantly refined and reshaped by their occupants.
This issue of Design Ecologies (DES) will focus on how bodies change spaces physically and mentally through our relationships with them, through them and from them. Particular concerns will focus on how revisiting the same space multiple times can change our understanding and can be recorded as an architecture of varying power. What we touch, we edit the space and leave a residue in the actual space. Architecture could be viewed as the relationship between the amateur and professional in space-making and habitation from who instructs whom to who informs whom. Do we have the methods to communicate the modalities of multiple habitants in one space over an extended period of time? Could we view an architecture of varying power as a layering of knowledge and our relationship of space over time? This issue on ‘Architectures of Varying Power’ will focus on articles.
Hypoparathyroidism, sensorineural deafness and renal disease (HDR) syndrome due to a novel GATA3 mutation p.Ala287Asp
Authors: Vroegindewey Luke , Kim John , Joseph Dennis J 
Published: December 2024

SummaryHDR is a rare autosomal dominant genetic disorder characterized by the triad of hypoparathyroidism, sensorineural deafness and renal anomalies caused by haploinsufficiency loss of function of the GATA-binding protein 3 (GATA3) gene. We present a case of a 56-year-old male diagnosed with hypoparathyroidism, sensorineural deafness, renal hypoplasia and epilepsy. Genetic testing revealed a novel GATA3 heterozygous mutation c.860C>A with a predicted amino acid substitution p.Ala287Asp. This hitherto unreported missense GATA mutation was characterized by a relatively late-onset and milder phenotype of the HDR triad.Learning pointsGATA3 gene mutations located on chromosome 10p cause haploinsufficiency of the GATA3 protein affecting fetal development of the parathyroid glands, inner ear and renal anomalies, resulting in HDR syndrome with an autosomal dominant inheritance pattern.Also known as Barakat syndrome, it has been reported in less than 200 cases with an identified mutation, each having a varied phenotypic presentation without consistent genotypic correlation.We present a patient with HDR syndrome who tested positive for a novel mutation c.860C>A, resulting in a missense substitution of amino acids p.Ala287Asp in the GATA3 gene.Clinicians who identify this rare triad of hypoparathyroidism, sensorineural deafness and renal anomalies should further investigate with genetic testing for GATA3 mutations.