bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is too much salt harmful? Yes
Authors: Agócs Róbert , Sugár Dániel , Szabó Attila J. 
Published: November 2019

AbstractThe contribution of high sodium intake to hypertension and to the severity of immune-mediated diseases is still being heatedly debated in medical literature and in the lay media. This review aims to demonstrate two conflicting views on the topic, with the first part citing the detrimental effects of excessive salt consumption. Sodium plays a central role in volume and blood pressure homeostasis, and the positive correlation between sodium intake and blood pressure has been extensively researched. Despite the fact that the average of global daily salt consumption exceeds recommendations of international associations, health damage from excessive salt intake is still controversial. Individual differences in salt sensitivity are in great part attributed to this contradiction. Patients suffering from certain diseases as well as other vulnerable groups—either minors or individuals of full age—exhibit more pronounced blood pressure reduction when consuming a low-sodium diet. Furthermore, findings from the last two decades give insight into the concept of extrarenal sodium storage; however, the long-term consequences of this phenomenon are lesser known. Evidence of the relationship between sodium and autoimmune diseases are cited in the review, too. Nevertheless, further clinical trials are needed to clarify their interplay. In conclusion, for salt-sensitive risk groups in the population, even stricter limits of sodium consumption should be set than for young, healthy individuals. Therefore, the question raised in the title should be rephrased as follows: “how much salt is harmful” and “for whom is elevated salt intake harmful?”
Effects on patient-reported outcomes of “Screening of Distress and Referral Need” implemented in Dutch oncology practice
Authors: van Nuenen Floor M. , Donofrio Stacey M. , Tuinman Marrit A. , van de Wiel Harry B. M. , Hoekstra-Weebers Josette E. H. M. 
Published: November 2019

Abstract
Purpose
This study investigated the effect of the “Screening for Distress and Referral Need” (SDRN) process (completing a screening instrument; patient-caregiver discussion about the patient’s responses, regardless of distress level, and possible referral to specialized care), implemented in Dutch oncology practice on patient-reported outcomes (PROs).

Methods
A non-randomized time-sequential study was conducted to compare two cohorts. Cohort 1 respondents (C1) were recruited before and cohort 2 respondents (C2) after SDRN implementation in nine Dutch hospitals. Participants completed the EORTC-QLQ-C30, HADS, Patient Satisfaction Questionnaire-III, and the Distress Thermometer and Problem List (DT&PL). Descriptive analyses and univariate tests were conducted.

Results
C2 respondents (N = 422, response = 54%) had significantly lower mean scores on the practical (t = 2.3; p = 0.02), social (t = 2.3; p = 0.03), and emotional PL domains (t = 2.9; p = 0.004) compared with C1 (N = 518, response = 53%). No significant differences were found on quality of life, anxiety, depression, satisfaction with care, distress level, the spiritual and physical PL domains, or on referral wish.

Conclusions
After implementation of SDRN, patients report significantly fewer psychosocial (practical, social, and emotional) problems on the DT/PL but responses on the other patient-reported outcomes were comparable. These results add to the mixed evidence on the beneficial effect of distress screening. More and better focused research is needed.
Investigating Conceptual Models for the Relationship Between Depression and Condomless Sex Among Gay, Bisexual, and Other Men Who have Sex with Men: Using Structural Equation Modelling to Assess Mediation
Authors:   for the AURAH Study Group, Miltz A. R. , Rodger A. J. , Lepri A. Cozzi , Sewell J. , Nwokolo N. C. , Allan S. , Scott C. , Ivens D. , Lascar M. , Speakman A. , Phillips A. N. , Sherr L. , Collins S. , Elford J. , Lampe F. C. 
Published: November 2019

AbstractThe aim of this study is to investigate five hypothesized mechanisms of causation between depression and condomless sex with ≥ 2 partners (CLS2+) among gay, bisexual, and other men who have sex with men (GBMSM), involving alternative roles of self-efficacy for sexual safety and recreational drug use. Data were from the AURAH cross-sectional study of 1340 GBMSM attending genitourinary medicine clinics in England (2013–2014). Structural equation modelling (SEM) was used to investigate which conceptual model was more consistent with the data. Twelve percent of men reported depression (PHQ-9 ≥ 10) and 32% reported CLS2+ in the past 3 months. AURAH data were more consistent with the model in which depression was considered to lead to CLS2+ indirectly via low self-efficacy for sexual safety (indirect Beta = 0.158; p < 0.001) as well as indirectly via higher levels of recreational drug use (indirect Beta = 0.158; p < 0.001). SEM assists in understanding the relationship between depression and CLS among GBMSM.
The influence on quality of life of intermittent scheduling in first- and second-line chemotherapy of patients with HER2-negative advanced breast cancer
Authors:   the Dutch Breast Cancer Research Group (BOOG), Claessens Anouk K. M. , Timman Reinier , Busschbach Jan J. , Bouma Jeanette M. , Rademaker-Lakhai Jeany M. , Erdkamp Frans L. G. , Tjan-Heijnen Vivianne C. G. , Bos Monique E. M. M. 
Published: November 2019

Abstract
Background
The Stop&Go study randomized patients with advanced breast cancer to intermittent (two times four) or continuous (eight subsequent cycles) first- and second-line chemotherapy.

Methods
QoL was measured with RAND-36 questionnaires every 12 weeks. The primary objective was to estimate differences in changes from baseline between intermittent and continuous treatment. An effect size of 0.5 SD (5 points) was considered clinically meaningful.

Results
A total of 398 patients were included with a median follow-up of 11.4 months (IQR 5.6–22.2). Mean physical QoL baseline scores were 38.0 resp. 38.2, and mental scores 45.0 resp. 42.4 for intermittent and continuous treatment. Physical QoL declined linearly in the intermittent arm causing a clinically meaningful difference of 5.40 points at 24 months (p < 0.001), while scores in the continuous arm stabilized after a small decline of ± 3.4 points at 12 months. Conversely, mental QoL was fairly stable and even improved with 1.58 (p = 0.005) and 2.48 points (p < 0.001) at 12 months for intermittent and continuous treatment, respectively. When comparing arms for both components in changes from baseline, the maximum differences were 2.46 (p = 0.101) and 1.95 points (p = 0.182) for physical and mental scores, both measured at 30 months and in favor of continuous treatment.

Conclusion
Intermittent first- and second-line chemotherapy in patients with HER2-negative advanced breast cancer showed a trend for worse impact on QoL compared to continuous chemotherapy, with neither significant nor meaningful differences in course. We recommend prescribing chemotherapy continuously until progressive disease or unacceptable toxicity.
Trial registration EudraCT 2010-021519-18; BOOG 2010-02
Achieving Responsible Management Learning Through Enriched Reciprocal Learning: Service-Learning Projects and the Role of Boundary Spanners
Authors: Fougère Martin , Solitander Nikodemus , Maheshwari Sanchi 
Published: November 2019

AbstractThrough its focus on deep and experiential learning, service-learning (SL) has become increasingly popular within the business school curriculum. While a reciprocal dimension has been foundational to SL, the reciprocality that is emphasized in business ethics literature is often on the relationship between the service experience and the academic content, rather than reciprocal learning of the service providers (students) and the recipients (organizations and their managers), let alone other stakeholders. Drawing on the notion of enriched reciprocal learning and on Aristotle’s typology of modes of knowing, we (1) revisit reciprocal learning by illustrating what kinds of learning occur for server and served in four SL projects from a project course in CSR, and (2) emphasize the role of boundary spanners from the project organizations in making this reciprocal learning happen and translating the various types of student learning in ways that are useful for their organizations. We find that when boundary spanners are particularly engaged at making the projects impactful, they contribute to making the learning experiences of students, managers (including themselves) and sometimes other stakeholders useful, multidimensional, and ultimately rewarding.
Geochemical equilibrium determination using an artificial neural network in compositional reservoir flow simulation
Authors: Guérillot Dominique , Bruyelle Jérémie 
Published: November 2019

AbstractThe fluid injection in sedimentary formations may generate geochemical interactions between the fluids and the rock minerals, e.g., CO2storage in a depleted reservoir or a saline aquifer. To simulate such reactive transfer processes, geochemical equations (equilibrium and kinetics equations) are coupled with compositional flows in porous media in order to represent, for example, precipitation/dissolution phenomena. The aim of the decoupled approach proposed consists in replacing the geochemical equilibrium solver with a substitute method to bypass the huge consuming time required to balance the geochemical system while keeping an accurate equilibrium calculation. This paper focuses on the use of artificial neural networks (ANN) to determine the geochemical equilibrium instead of solving geochemical equations system. To illustrate the proposed workflow, a 3D case study of CO2storage in geological formation is presented.
A novel haplotype of ‘Candidatus Liberibacter solanacearum’ found in Apiaceae and Polygonaceae family plants
Authors: Haapalainen Minna , Latvala Satu , Wickström Annika , Wang Jinhui , Pirhonen Minna , Nissinen Anne I. 
Published: November 2019

AbstractA previously unknown haplotype of the plant pathogen ‘CandidatusLiberibacter solanacearum’ (Lso) was found in cultivated carrots and parsnips in eastern Finland. That same haplotype was found in western Finland, over 300 km away, in the family Polygonaceae, the speciesFallopia convolvulus(wild buckwheat) andPersicaria lapathifolia(pale persicaria) growing as weeds within carrot and parsnip fields. The infected plants, both apiaceous and polygonaceous, showed symptoms of foliar discolouration. This is the first report of Lso bacteria in plants of the family Polygonaceae. The finding that the polygonaceous plants infected with a previously unknown haplotype of Lso were growing among the apiaceous plants infected with Lso haplotype C suggests that these two haplotypes might be transmitted by different vectors. Phylogenetic analyses showed that the new haplotype, called haplotype H, is distinct from the previously characterized haplotypes and appears to have diverged early from their common ancestor. Multi-locus sequence analysis revealed four different sequence types (strains) within the haplotype H. These findings suggest that the haplotype H is likely to be endemic in northern Europe and that the genetic diversity within the Lso species is higher than previously assumed.
Co-solvent Effect on Spontaneous Formation of Large Nanoscale Structures in Catanionic Mixtures in the Anionic-Rich Region
Authors: Golmohammadi Farhad , Amiri Masoud , Gharibi Hussein , Yousefi Ali , Safari Meysam 
Published: November 2019

AbstractThe aggregation behavior was investigated in mixtures of sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB) (anionic-rich catanionic) solutions. The study was conducted in solutions of water–ethylene glycol (EG) by means of surface tension, conductometry, cyclic voltammetry, zeta potential measurements, transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques. The degree of counterion dissociation (α), critical micelle concentration, aggregation numbers, interfacial properties, interparticle interaction parameters, and morphology of aggregates were determined. Based on regular solution theory, the cosolvent effects between SDS and CTAB as surfactants were also analyzed for both mixed monolayers at mixed micelles (βM) and the air/liquid interface (βσ). It was shown that the formation of large aggregates occurred in the presence of an excess of anionic surfactant. A phase transition from cylindrical micelles to spherical micelles in the anionic-rich regime was observed with an increase in the EG volume fraction. The inter particle interactions were assessed in terms of cosolvent effects on the micellar surface charge density and the cylindrical-to-spherical morphology change. Zeta potential and size of the aggregates were determined using dynamic light scattering and confirmed the models suggested for the processes taking place in each system.
The cost-effectiveness analysis of drug therapy versus surgery for symptomatic adenoid hypertrophy by a Markov model
Authors: Xiao Han , Huang Jinqiang , Liu Weifeng , Dai Zihao , Peng Sui , Peng Zhenwei , Liang Ruiming , Ma Renqiang , Wen Yihui , Li Jian , Wen Weiping 
Published: November 2019

Abstract
Purpose
Adenoid hypertrophy (AH) is common among young children. Adenoid-based surgery and drug therapy could be applied for symptomatic AH patients, yet the treatment decision is difficult to make due to the diverse cost and efficacy between these two treatments.

Methods
A Markov simulation model was designed to estimate the cost-effectiveness (CE) of the adenoid-based surgery and the drug therapy for symptomatic AH patients. Transition probabilities, costs and utilities were extracted from early researches and expert opinions. Simulations using two set of parameter inputs for China and the USA were performed. Primary outcome was cost per QALY gained over a 6-year period. Deterministic and probabilistic sensitivity analyses were also conducted.

Results
The utility for the surgery group and the drug group were 4.10 quality-adjusted life years (QALYs) and 3.58 QALYs, respectively. The cost of the surgery group was more than that of the drug group using model parameters specific to China ($1069.0 vs. $753.7) but was less for the USA ($1994.4 vs. $3977.7). Surgery was dominant over drug therapy when US specific parameters were used. Surgery group had an ICER of $604.0 per QALY when parameters specific to China was used.

Conclusion
Surgery is cost-effective in the simulations for both China and the USA at WTP thresholds of $9633.1 and $62,517.5, respectively.
Morphological differences of hindlimb levers between wild and farmed American mink (Neovison vison) and implications for reintroduction of mustelids
Authors: Sun Jian , Zhou Xiaoli , Xu Yanchun , Hua Yan , Dahmer Thomas D. , Yang Shuhui 
Published: November 2019

AbstractReintroduction is an important strategy to restore or re-establish wild populations of endangered species. Pre-release training is a necessary step to ensure post-reintroduction survival. However, studies reported contradicting outcomes after pre-release training of juveniles and adults. This study used farmed and feral American mink (Neovison vison) to analyze the influence of captive breeding on the morphology, structure and efficiency of the two major hindlimb levers, the femur and tibia pivoted by hip and knee joints that are essential for locomotion. Results showed that captive breeding did not alter the sexual dimorphism of the two levers that are related to survival in the wild. Captive-bred mink showed slightly altered morphology of the femur and fundamental structure of the hindlimb levers that improved efficiency, but this resulted in reduction of performance related to foraging in both terrestrial and aquatic environments, especially for females. These findings suggest that reintroduction of mustelid as exampled by the mink here should focus on juveniles because the skeletal alterations associated with captive rearing were recorded only among adults and are irreversible in adulthood. In contrast, captive-reared juveniles showed no skeletal alterations and would be expected to recovery from any atrophy of the muscular system caused by captive rearing for shorter durations. Our results support the application of pre-release training of juveniles in enriched environments as a method for alleviating structural alteration of appendages and enhancing locomotion to increase survival probability in complex habitats.
Optimization of waterflooding performance by using finite volume-based flow diagnostics simulation
Authors: Boumi Mfoubat Hypp Renaud Niongui , Zaky Esther Itekile 
Published: November 2019

AbstractFrom a visual point of view, volumetric information about reservoir portioning and communication such as sweep, flow patterns, and drainage zones are longer better interpreted and pictured when presented by an average volumetric flux calculation. To this hand, finite volume discretization can be used to substitute streamline simulation-based finite difference to assess flow diagnostic information. Herein, we use finite volume-based flow diagnostics to optimize waterflooding. In particular, we discretize in finite volume the flow equation from Darcy’s law single-phase incompressible flow steady state combining with two auxiliary flow equations, time of flight and stationary tracers using the two-point flux approximation to describe fluid particles motion and flow lines. In addition, with the estimation of dynamic heterogeneity, we compute the Lorenz coefficient to highlight the reservoir flow and storage capacity characterization. To optimize waterflooding rates, we first, use an objective function the equalized Lorenz coefficient got through the evaluation of average travel time in cells to increase sweep efficiency and decrease the dynamic heterogeneity coefficient. Second, following the same target, we use the flow diagnostic interactive tools to study the volumetric sweep displacement front and harmonize the flooding breakthrough. In this work, our conceptual approach is to see the reservoir initially filled with oil; then, optimizing the Lorenz coefficient leads us to an oil recovery improvement. To be pragmatic, we apply our waterflooding performance optimization model on two case studies, the ninth SPE comparative solution project, a reexamination of black-oil (synthetic case) and ZHNBA Chinese oilfield (real field dataset).
Vocabulary in learning processes towards conceptual understanding of equivalent fractions—specifying students’ language demands on the basis of lexical trace analyses
Authors: Wessel Lena 
Published: November 2019

AbstractAlthough the teaching of vocabulary in mathematics lessons is requested in content- and language-integrated lesson designs, the clarification of the specific lexical language demands is still an open question for many mathematical topics. In a content- and language-integrated lesson design towards understanding the concept of equivalent fractions, the vocabulary (words and phrases) used by 17 students has been analyzed with qualitative means of data analysis. The qualitative in-depth analyses underline the importance of meaning-related vocabulary for making structural relations between the fractions in view explicit. Quantitative analyses of inventoried vocabulary for the four categories “self-initiated by students,” “triggered by teaching material,” “triggered by teacher,” or “triggered by peers” show the relations of collective and autonomous vocabularies from which the students retrieve their lexical means in oral and written language production.
Gender and collaboration patterns in a temporal scientific authorship network
Authors: Bravo-Hermsdorff Gecia , Felso Valkyrie , Ray Emily , Gunderson Lee M. , Helander Mary E. , Maria Joana , Niv Yael 
Published: November 2019

AbstractOne can point to a variety of historical milestones for gender equality in STEM (science, technology, engineering, and mathematics), however, practical effects are incremental and ongoing. It is important to quantify gender differences in subdomains of scientific work in order to detect potential biases and monitor progress. In this work, we study the relevance of gender in scientific collaboration patterns in the Institute for Operations Research and the Management Sciences (INFORMS), a professional society with sixteen peer-reviewed journals. Using their publication data from 1952 to 2016, we constructed a large temporal bipartite network between authors and publications, and augmented the author nodes with gender labels. We characterized differences in several basic statistics of this network over time, highlighting how they have changed with respect to relevant historical events. We find a steady increase in participation by women (e.g., fraction of authorships by women and of new women authors) starting around 1980. However, women still comprise less than 25% of the INFORMS society and an even smaller fraction of authors with many publications. Moreover, we describe a methodology for quantifying the structural role of an authorship with respect to the overall connectivity of the network, using it to measure subtle differences between authorships by women and by men. Specifically, as measures of structural importance of an authorship, we use effective resistance and contraction importance, two measures related to diffusion throughout a network. As a null model, we propose a degree-preserving temporal and geometric network model with emergent communities. Our results suggest the presence of systematic differences between the collaboration patterns of men and women that cannot be explained by only local statistics.