bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the performance of a hybrid CPU/GPU 1D2D coupled model for real flood cases
Authors: Echeverribar Isabel , Morales-Hernández Mario , Brufau Pilar , García-Navarro Pilar 
Published: July 2020

Abstract
Coupled 1D2D models emerged as an efficient solution for a two-dimensional (2D) representation of the floodplain combined with a fast one-dimensional (1D) schematization of the main channel. At the same time, high-performance computing (HPC) has appeared as an efficient tool for model acceleration. In this work, a previously validated 1D2D Central Processing Unit (CPU) model is combined with an HPC technique for fast and accurate flood simulation. Due to the speed of 1D schemes, a hybrid CPU/GPU model that runs the 1D main channel on CPU and accelerates the 2D floodplain with a Graphics Processing Unit (GPU) is presented. Since the data transfer between sub-domains and devices (CPU/GPU) may be the main potential drawback of this architecture, the test cases are selected to carry out a careful time analysis. The results reveal the speed-up dependency on the 2D mesh, the event to be solved and the 1D discretization of the main channel. Additionally, special attention must be paid to the time step size computation shared between sub-models. In spite of the use of a hybrid CPU/GPU implementation, high speed-ups are accomplished in some cases.
Internal freedom as a foundation of strength and sovereignty of the nation in the thought of Primate Stefan Wyszyński
Authors: Krzysztofka Łukasz 
Published: July 2020

Internal freedom is at the heart of all human freedom. This truth was present in the thought and teaching of Cardinal Stefan Wyszyński. The Primate also expressed it through the testimony of his life – a man who will not hesitate to go to prison. The foundation of freedom in Cardinal Wyszyński’s life was faith. He conveyed this truth, teaching that freedom of spirit is constantly gained through living in accordance with the Decalogue and teachings of Jesus, that is, being faithful to God, the Church and the Gospel. The Primate saw the guarantee of internal freedom in the things seemingly opposite – namely in the surrender to slavery. However, in the Primate’s opinion, it was slavery which was giving true freedom – that is, slavery to love, sacrificing for the freedom of the Church to God and His Mother. He said that he wanted to replace this terrible, heavy slavery of modern man with sweet, maternal slavery in Mary’s arms. In this, he saw the salvation of a nation in political enslavement, enslavement to the pressure of atheistic morality, social and economic enslavement, as well as enslavement to sins and addictions. Cardinal Wyszyński also called for an attitude of service to personal and social life, to serve one another in love, justice and peace. In Cardinal’s conviction, it was the faith in the martyred and resurrected Christ that was a source of special inspiration for Poles, because it taught them that the nation was not allowed to come to terms with its own death, inflicted by the injustice of others, but they should look for ways to resurrection. Freedom is a fundamental condition for the development of a nation. Only an internally free nation is capable of achieving freedom and sovereignty, for it is love that is the true fulfilment of freedom.
Biopolymeric, Nanopatterned, Fibrous Carriers for Wound Healing Applications
Authors: Sharma Ameya , Puri Vivek , Kumar Pradeep , Singh Inderbir 
Published: July 2020

Background:
Any sort of wound injury leads to skin integrity and further leads to wound formation.
Millions of deaths are reported every year, which contributes to an economical hamper world widely, this accounts
for 10% of death rate that insight into various diseases.

Current Methodology:
Rapid wound healing plays an important role in effective health care. Wound healing is a
multi-factorial physiological process, which helps in the growth of new tissue to render the body with the imperative
barrier from the external environment. The complexity of this phenomenon makes it prone to several abnormalities.
Wound healing, as a normal biological inherent process occurs in the body, which is reaped through four
highly defined programmed phases, such as hemostasis, inflammation, proliferation, and remodeling and these
phases occur in the proper progression. An overview, types, and classification of wounds along with the stages of
wound healing and various factors affecting wound healing have been discussed systematically. Various biopolymers
are reported for developing nanofibers and microfibers in wound healing, which can be used as a therapeutic
drug delivery for wound healing applications. Biopolymers are relevant for biomedical purposes owing to
biodegradability, biocompatibility, and non- toxicity. Biopolymers such as polysaccharides, proteins and various
gums are used for wound healing applications. Patents and future perspectives have been given in the concluding
part of the manuscript. Overall, applications of biopolymers in the development of fibers and their applications in
wound healing are gaining interest in researchers to develop modified biopolymers and tunable delivery systems
for effective management and care of different types of wounds.
The Effects of Evening-Primrose Oil on Menopausal Symptoms: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Christelle Karen , Zulkfili Maryam Mohd , Noor Norhayati Mohd , Draman Nani 
Published: July 2020

Background:Evening primrose oil (EPO) has been a treatment option for reducing menopausal symptoms, but evidence for its use is inadequate.Objective:The study aimed to determine the effectiveness of EPO in treating menopausal symptoms among peri and postmenopausal women.Study design:This is a systematic review with meta-analyses of randomised clinical trials (RCTs).Methods:We searched CENTRAL, Medline, Embase and trial registries for relevant RCTs. The methodology and reporting were carried out grounded on references from the Cochrane collaboration and the preferred reporting items for systematic reviews and meta-analyses statement. Review Manager version 5.3.5 was used to perform all the statistical analyses.Results:Five RCTs, recruiting a total of 402 peri and postmenopausal women were identified. EPO did not reduce the frequency of daily vasomotor symptoms (MD 0.01 episodes, 95% CI -0.54 to 0.57, P=0.960), frequency of daytime hot flash episodes (MD -0.51 episodes, 95% CI -2.05 to 1.03, P=0.510), frequency of night sweat episodes (MD 0.33 episodes, 95% CI -0.48 to 1.13, P=0.430) and severity of vasomotor symptoms (SMD -0.45, 95% CI -1.56 to 0.66, P=0.420) in comparison to control. EPO was associated with a minimal reduction in the severity of overall menopausal symptoms in comparison to control (SMD -1.18; 95% CI-2.18 to -0.18, P=0.02). There were insufficient data to pool results for musculoskeletal symptoms, mood, sexuality, sleeping disorders and quality of life.Conclusion:EPO may reduce the severity of overall menopausal symptoms but is not effective to reduce the frequency and severity of vasomotor symptoms. The evidence quality ranged from very low to moderate. Further research is needed to enhance related evidence.
C1 Inhibitor Administration Reduces Local Inflammation and Capillary Leakage, Without Affecting Long-term Wound Healing Parameters, in a Pig Burn Wound Model
Authors: Korkmaz Halil Ibrahim , Ulrich Magda M.W. , Wieringen Wessel N. Van , Doǧan Hatice , Vlig Marcel , Emmens Reindert W. , Meyer Klaas W. , Sinnige Paul , Zeerleder Sacha , Wouters Diana , Ham Marieke S. Van , Zuijlen Paul P.M. Van , Krijnen Paul A.J. , Niessen Hans W.M. 
Published: July 2020

Background:Burns induce a boost in local and systemic complement levels as well as immune cell infiltration in the burn wound, that may negatively affect wound healing.Objective:In this study, the effects of long-term treatment with complement inhibitor C1 esterase inhibitor (C1inh) on post-burn inflammation and wound healing parameters were analyzed in time up to 60 days post-burn.Method:Burned pigs were treated either with or without C1inh up to 15 days post-burn. Burn wound biopsies and blood were collected at different time points up to 60 days post-burn. Thereafter, complement in blood as well as complement and immune cells in the wound, capillary leakage, necrosis, reepithelialization and wound contraction were quantified.Results:No significant differences in complement C3 blood levels were observed at any time point between C1inh-treated and control pigs. In the wound, complement C4 levels were significantly lower in the C1inh group than in controls at day 3-6 and 21-30 post-burn. Similarly, C3 levels, neutrophil and macrophage infiltration in the wound were, although not statistically significant, reduced in C1inh-treated pigs at day 9-14 post-burn. No differences in lymphocyte infiltration in the wound were found between C1inh and control pigs. C1inh-treated pigs also showed reduced capillary leakage. Despite these effects, no significant differences in the long-term wound healing parameters necrosis, reepithelialization and wound contraction were observed between C1inh and control pigs.Conclusion::In pigs 15 days of C1inh treatment after burn, leads to a reduction in local inflammation and capillary leakage in the burn wound without affecting long-term wound healing parameters.
Hacia una literacidad del fracaso escolar y del abandono temprano desde las voces de adolescentes y jóvenes. Resistencias, «cicatrices» y destinos.
Authors: Santana Bonilla Pablo Joel 
Published: July 2020

El libro reseñado presenta los resultados de una investigación acerca del fracaso y el abandono educativo temprano. Se caracteriza por su enfoque cualitativo, que da voz a las adolescentes y jóvenes protagonistas, y que trata de considerar los diversos factores y dimensiones desde la perspectiva de la interseccionalidad. Se plantea que la educación pública debe cumplir su papel como promotora de la justicia y la solidaridad y, sin embargo, advierte que la diferencia y la desigualdad pueden hallar inadvertidamente su caldo de cultivo en la propia democracia.
La lectura del libro puede ser útil a investigadores e investigadoras interesados en la temática, pero también a otras audiencias, como docentes de secundaria o estudiantes en formación inicial para ser docentes de secundaria. Los casos también pueden servir de referencia en cursos de metodología de la investigación educativa.
Hydronephrosis due to ureteropelvic junction obstruction in left pelvic kidney
Authors: Sizonov V. V. , Shidaev A. Kh-A. , Makarov A. G. , Gorishniaya E. E. 
Published: July 2020

The article presents a rare case of hydronephrosis due to ureteropelvic junction obstruction (UPJO) in the pelvic kidney. The rarity of this anomaly determines the presence of a limited number of publications on this problem in modern literature. For the following reasons, we find the case presented by us interesting. On the one hand, there was an erroneous tactic of monitoring the patient by outpatient specialists and it was based on data from ultrasound (US) alone, ignoring data from ante- and postnatal ultrasound, which noted the presence of a significant dilatation of the pelvis. On the other hand, the revealed dissonance between the large pelvis and the non-dilated calyces, the inability to visualize the expected wide communications between the calyces and the pelvis, which created the illusion of the presence of a pararenal cyst. The patient underwent Lichtenberg pyeloplasty, which has advantages over dissecting pyeloplasty, when the cause of the UPJO, as in our patient, was a high insertion of the ureter with a structurally normal ureteropelvic junction.
Indigenous Perspective of Lymphatic Filariasis in Endemic Region Indonesia
Authors: Ipa Mara , Puji Astuti Endang , Ikawati Bina , Wijayanti Tri , Yulidar Yulidar , Ramadhan Nur , Nurdjana Made Agus , Rahayu Nita , Yunarko Rais , Dwilaksono Agung 
Published: July 2020

Lymphatic filariasis disease impacts the patients both socially and economically. Health seeking behavior was related to the variation of local perceived. This research is required to explore the wide variety of local perspectives as input into treatment program intervention strategies. The study was conducted in 12 districts in Indonesia, namely Pidie, North Aceh, Aceh Jaya, West Pasaman, South Pesisir, Subang, Tangerang, West Kota Waringin, North Hulu Sungai, Donggala, Bombana, and Asmat. Qualitative methods with the health belief model approach were used to assess the community’s knowledge about lymphatic filariasis disease and its treatments. This study used 24 informants consisting of 14 men and 10 women. Results showed there were 9 out of 12 regions that have a localized concept of lymphatic filariasis disease. Most informants believe that the disease occured as a result of the curse of the ancestor or the curse of visiting a certain place, or supernatural power. Most informants stated that seeking indigenous healers was carried out if the informant felt that self-treatment did not produce the result as expected. There was a tendency between knowledge and elimination efforts of lymphatic filariasis disease. Therefore, it is recommended to provide a better understanding of local knowledge about lymphatic filariasis
Penggunaan Insektisida Rumah Tangga untuk Mencegah dan Mengendalikan Aedes aegypti di Permukiman di Provinsi Sumatera Utara
Authors: Sunaryo Sunaryo , Widiastuti Dyah 
Published: July 2020

Dengue prevention and control still depend on insecticides usage. Household insecticides were the most preferable choice to prevent and control Aedes aegypti at settlements. The purpose of this study was to analyze the usage of household insecticides to prevent and control Ae. aegypti in settlement, especially in North Sumatra Province. The research was conducted during April-November 2015. The larvae examination and interviews were conducted on 900 respondents in three districts in North Sumatra Province (Tebing Tinggi, Pematang Siantar and Deli Serdang). The results of the study showed that the house index, container index, breteau index and densty figure in three districts were revealed that the regions were at moderate and high risk of dengue transmission. Most people in three districts use household insecticide at night to prevent dengue transmission. In conclusion, the household insecticides usage by the community in North Sumatra Province is ineffective to Ae. aegypti prevent and control in settlements, because the community only use adulticide and the time of use of insecticide is not in accordance with the activities of Ae. aegypti to transmit DHF during the daytime without any larva control activity.
Fasting Serum Fructose Levels Are Associated With Risk of Incident Type 2 Diabetes in Middle-Aged and Older Chinese Population
Authors: Chen Ying , Lin Huandong , Qin Li , Lu Youli , Zhao Lin , Xia Mingfeng , Jiang Jingjing , Li Xiaomu , Yu Chen , Zong Geng , Zheng Yan , Gao Xin , Su Qing , Li Xiaoying 
Published: July 2020

OBJECTIVE
We investigated the relationship between fasting serum fructose levels and the risk of incident type 2 diabetes in a prospective Chinese cohort.

RESEARCH DESIGN AND METHODS
Among 949 community-based participants aged ≥40 years without diabetes at baseline, fasting serum fructose levels were measured using liquid chromatography–tandem mass spectrometry. The participants were followed up for the occurrence of diabetes. Cox regression models were performed to analyze the effect of fasting serum fructose levels on risk of incident diabetes.

RESULTS
During a median of 3.5 years’ follow-up, 179 of 949 (18.9%) participants developed type 2 diabetes. Elevated fasting serum fructose levels were associated with an increased risk of incident diabetes in a dose-response manner. After adjustment for age, sex, BMI, lipid profiles, blood pressure, liver function, smoking and drinking status, baseline glucose level, and sugar-sweetened beverage consumption, a 1-SD increased fasting fructose level was associated with a 35% (95% CI 1.08–1.67) increased risk of developing diabetes. After further adjustment for serum uric acid and estimated glomerular filtration rate, the association was partially attenuated (hazard ratio 1.33 [95% CI 1.07–1.65]). The association was similar by age, prediabetes status, BMI, and family history of diabetes but attenuated in women (P for heterogeneity = 0.037).

CONCLUSIONS
Elevated fasting serum fructose levels were independently associated with increased risk of incident type 2 diabetes in a middle-aged and older Chinese population. Our data suggest that higher fasting serum fructose levels might serve as a biomarker and/or a contributor to incident diabetes.
Randomized Double-Blind Clinical Trial Comparing Ultra Rapid Lispro With Lispro in a Basal-Bolus Regimen in Patients With Type 2 Diabetes: PRONTO-T2D
Authors: Blevins Thomas , Zhang Qianyi , Frias Juan P. , Jinnouchi Hideaki , Chang Annette M. 
Published: July 2020

OBJECTIVE
To evaluate the efficacy and safety of ultra rapid lispro (URLi) versus lispro in patients with type 2 diabetes on a basal-bolus insulin regimen.

RESEARCH DESIGN AND METHODS
This was a phase 3, treat-to-target, double-blind 26-week study. After an 8-week lead-in to optimize basal insulin glargine or degludec in combination with prandial lispro treatment, patients were randomized to blinded URLi (n = 336) or lispro (n = 337) injected 0–2 min prior to meals. Patients could continue metformin and/or a sodium–glucose cotransporter 2 inhibitor. The primary end point was change in HbA1c from baseline to 26 weeks (noninferiority margin 0.4%), with multiplicity-adjusted objectives for postprandial glucose (PPG) excursions during a standardized meal test.

RESULTS
HbA1c improved for both URLi and lispro, and noninferiority was confirmed: estimated treatment difference (ETD) 0.06% (95% CI −0.05; 0.16). Mean change in HbA1c was −0.38% for URLi and −0.43% for lispro, with an end-of-treatment HbA1c of 6.92% and 6.86%, respectively. URLi was superior to lispro in controlling 1- and 2-h PPG excursions: 1-h ETD, −0.66 mmol/L (95% CI −1.01, −0.30); 2-h ETD, −0.96 mmol/L (−1.41, −0.52). Significantly lower PPG excursions were evident from 0.5 to 4.0 h postmeal with URLi treatment. There were no significant treatment differences in rates of severe or documented hypoglycemia (&lt;3.0 mmol/L). Incidence of overall treatment-emergent adverse events was similar between treatments.

CONCLUSIONS
URLi compared with lispro in a basal-bolus regimen was confirmed to be noninferior for HbA1c and superior to lispro for PPG control in patients with type 2 diabetes.
Anti–PD-1 Therapy–Associated Type 1 Diabetes in a Pediatric Patient With Relapsed Classical Hodgkin Lymphoma
Authors: Samoa Raynald A. , Lee Hayley S. , Kil Sung H. , Roep Bart O. 
Published: July 2020

OBJECTIVE
Immune checkpoint inhibitors (ICIs) perturb T-cell regulatory pathways to enhance antitumor immunity. However, an increase reporting of ICI-associated diabetes is observed in adults. To our knowledge, no cases have been reported in the pediatric population.

RESEARCH DESIGN AND METHODS
We describe a pediatric case of ICI-associated type 1 diabetes in a 12-year-old Hispanic boy with Hodgkin lymphoma. The patient had a history of autologous hematopoietic stem cell transplantation and was treated with pembrolizumab after disease progression.

RESULTS
The patient was admitted for diabetic ketoacidosis after five cycles of pembrolizumab. The patient was discharged with daily insulin injections and has continued on exogenous insulin ever since.

CONCLUSIONS
The expanded ICI use may lead to more cases in pediatric patients as has been observed in adults. Considering the acute manifestation of diabetes and the added burden of lifelong insulin therapy, in particular for pediatric patients and their families, monitoring and education of ICI-associated diabetes in children is needed.
Akuntabilitas Perencanaan Kebutuhan dan Penganggaran Aset Tetap Kota Salatiga
Authors: Andhita Mega , Sucahyo Usil Sis 
Published: July 2020

Penelitian ini didorong oleh masih adanya beberapa ketidakselarasan dokumen dalam proses perencanaan ktetap di Kota Salatiga. Oleh karena itu penelitian ini ditujukan untuk mendeskripsikan akuntabilitas proses perencanaan kebutuhan dan penganggaran asset tetap di Pemerintah Kota Salatiga. Pertanyaan yang mau di jawab yaitu bagaimana mekanisme perencanaan kebutuhan dan penganggaran asset tetap Kota Salatiga, dan apakah mekanisme akuntabilitas Pemerintah Kota Salatiga yang akuntabel. Penelitian ini adalah penelitian kualitatif dengan metode analisis data adalah deskriptif kualitatif. Hasil penelitian menunjukkan bahwa mekanisme perencanaan kebutuhan dan penganggaran aset tetap Pemerintahan Kota Salatiga sudah melalui Renstra, Musrenbang, RKA SKPD, KUA PPAS, Nota Kesepakatan dan output terakhir berupa DPA SKPD. Sedangkan untuk mekanisme akuntabilitas perencanaan kebutuhan dan penganggaran aset tetap Pemerintah Kota Salatiga dapat dilihat dari pemenuhan dokumen berdasarkan Permendagri 19 tahun 2016 baik untuk perencanaan kebutuhan maupun penganggaran. Selain itu akuntabilitas berdasarkan perundang-undangan Pemerintah Kota Salatiga sudah menyesuaikan kebijakan dan perubahan amandemen.
PENCATATAN TRANSAKSI PADA USAHA KELUARGA SKALA KECIL DENGAN PENDEKATAN SOCIOEMOTIONAL WEALTH
Authors: Eka Wardhani Ananda 
Published: July 2020

Anggota keluarga sebagai pemilik atau pemangku kepentingan mayoritas dalam usaha keluarga sering kali ikut campur pada usaha dengan mengabaikan prinsip manajemen usaha. Penelitian ini bertujuan untuk untuk mengeksplorasi pencatatan Usaha Kecil Menengah (UKM) melalui pendekatan Socioemotional Wealth (SEW). Transaksi dan peran anggota keluarga di usaha keluarga Toko Ganda dalam lingkup. Data primer diperoleh melalui hasil wawancara dengan informan kunci yaitu pemilik usaha. Hasil penelitian menunjukkan bahwa keluarga masih memiliki pengaruh besar dalam menjalankan usaha terlebih dalam pencatatan transaksi sebagai dampak dari kesejahteraan keluarga yang menjadi dasar pertimbangan dalam pengambilan keputusan.Kata Kunci : Usaha Keluarga Skala Kecil , Socioemotional Wealth, Pencatatan Transaksi. Usaha Keluarga Skala Kecil , Socioemotional Wealth, Pencatatan Transaksi.Keywords:Small Scale Family Business, SocioemotionalWealth, Transaction Record.
Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102
Authors: Setiawan Agung , Kiromah Naelaz Zukhruf Wakhidatul , Widiastuti Tri Cahyani 
Published: July 2020

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.