bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes: first reported GCK-MODY in Perú
Authors: Lizarzaburu-Robles Juan Carlos , Gomez-de-la-Torre Juan Carlos , Castro-Mujica María del Carmen , Vento Flor , Villanes Sofia , Salsavilca Elizabeth , Guerin Chris 
Published: January 2020

Abstract
Background
Prevalence of maturity-onset diabetes of the young (MODY) is estimated between 1 and 2% of all diabetes cases. In Latin-America little information has been described about the frequency of the disease, perhaps due to limited access to genetic studies.

Case presentation
We present the case of a male patient with a history of two years of fatigue, mild hyperglycemia and intermittent polyuria, accompanied by a recent history of weight loss. He was diagnosed initially as type 2 diabetes, but in the follow-up as a patient with type 1 diabetes. He required relatively low doses of insulin and was evaluated in the endocrinology service at a hospital in Lima. The results of glucose, insulin and C-peptide in the oral glucose tolerance test (OGTT) performed were not consistent with a type 1 diabetes. Moreover, the age of the patient and the clinical characteristics did not strongly suggest a diagnosis of type 2 diabetes either. These clinical features had prompted us to carry out the genetic study. The genetic test performed with a genetic MODY panel through a massive sequencing. Heterozygous pathogenic for a variant in GCK gene was found c.629C>T p.(Thr210Met). His parents were negative for this variant after performed the genetic test.

Conclusions
This is the first case of MODY for a pathogenic variant in the GCK gene reported in Perú. The genetic evaluation of a clinical suspicion of MODY is important to confirm the diagnosis and establish an adequate treatment in patients.
Proteomic characterization of HaCaT keratinocytes provides new insights into changes associated with SDS exposure
Authors: Petushkova Natalia A. , Rusanov Alexander L. , Pyatnitskiy Mikhail A. , Larina Olesya V. , Zgoda Victor G. , Lisitsa Andrey V. , Luzgina Natalia G. 
Published: January 2020

AbstractBackgroundUsing human keratinocyte HaCaT cell line model, we screened for proteins that changed their content due to SDS exposure in non-toxic dose (25 μg/ml, as determined by the MTT assay and microscopic examination) during 48 h.MethodsThe altered level of proteins from HaCaT keratinocytes exposed to SDS was analyzed by LC-MS/MS approach and quantified using Progenesis LC software.ResultsThe Pathview map of 131 upregulated proteins was built, and enhancement of glycolysis/gluconeogenesis was found.ConclusionsThe results of our study admit the possibility of promotion of the cutaneous neoplasia and/or the peculiarity of the response of immortalized keratinocytes to the SDS treatment and provide new insights into possible role of SDS as integrator of diverse signaling that influence cell fate decisions.
An emerging threat Fileless malware: a survey and research challenges
Authors: Sudhakar  , Kumar Sushil 
Published: January 2020

AbstractWith the evolution of cybersecurity countermeasures, the threat landscape has also evolved, especially in malware from traditional file-based malware to sophisticated and multifarious fileless malware. Fileless malware does not use traditional executables to carry-out its activities. So, it does not use the file system, thereby evading signature-based detection system. The fileless malware attack is catastrophic for any enterprise because of its persistence, and power to evade any anti-virus solutions. The malware leverages the power of operating systems, trusted tools to accomplish its malicious intent. To analyze such malware, security professionals use forensic tools to trace the attacker, whereas the attacker might use anti-forensics tools to erase their traces. This survey makes a comprehensive analysis of fileless malware and their detection techniques that are available in the literature. We present a process model to handle fileless malware attacks in the incident response process. In the end, the specific research gaps present in the proposed process model are identified, and associated challenges are highlighted.
Expanding our views of science education to address sustainable development, empowerment, and social transformation
Authors: Kyle William C. 
Published: January 2020

AbstractOn 25 September 2015, the UN General Assembly adopted a resolution, which took effect 1 January 2016, to transform the world to better meet human needs and the requirements of economic transformation, while protecting the environment, ensuring peace and realizing human rights. Since 1987, there have been several global initiatives oriented toward sustainable development, yet science educators have often remained silent with respect to ensuring the goals of science education are linked intrinsically to the central tenets of sustainable development. Why such silence? Where are the voices of science educators?In this position statement, I offer a rationale for expanding our views of science education to address sustainable development, empowerment, and social transformation. Science education ought to be a primary vehicle for addressing the current and emerging global challenges facing humanity. All too often, science educators merely focus upon fostering awareness and concern for global challenges. Such an orientation falls short of the education discourse that ought to be oriented toward addressing the goals, aspirations, desires, and needs of youth, who presently number 1.8 billion and represent the largest segment of the global population being underserved. The active engagement of youth in sustainable development efforts is imperative to achieve the goals of the 2030 Agenda. Youth are not mere beneficiaries of the 2030 Agenda; they have a critical role in the implementation of the Sustainable Development Goals (SDGs).I offer a rationale for why science educators ought to become active agents in facilitating the engagement of youth in addressing global challenges facing humanity. Youth are demanding action; science educators ought to enable learners and communities to transform and reinvent the world they are inheriting.
Cognitive Function of Children and Adolescents With Congenital Adrenal Hyperplasia: Importance of Early Diagnosis
Authors: Messina Valeria , Karlsson Leif , Hirvikoski Tatja , Nordenström Anna , Lajic Svetlana 
Published: January 2020

Abstract

Context
Patients with classic congenital adrenal hyperplasia (CAH) are treated postnatally with lifelong glucocorticoid (GC) replacement therapy. Previous results on general cognitive ability in individuals with CAH have been conflicting.

Objective
To evaluate long-term cognitive effects of GC replacement therapy and the impact of early diagnosis in children with CAH.

Design and Setting
Observational study with patients from a single research institute.

Patients
32 children with CAH (mean age 11.5 years) identified through the Swedish national neonatal screening program for CAH and 52 matched population controls (mean age 10.7 years). Eleven (6 female) children with CAH who were treated prenatally with dexamethasone (DEX), (CAH-DEX) (mean age 11.7 years).

Intervention
GC replacement therapy, neonatal screening for CAH.

Measures
Cognitive abilities assessed with standardized neuropsychological tests (Wechsler scales, Span Board Test, Stroop Interference Test, NEPSY list learning).

Results
Children with CAH (not prenatally treated) performed equally well as population controls on a series of tests assessing general intellectual ability and executive functions. No significant differences were observed in cognitive performance between patients with different genotypes (null, non-null). Patients with salt-wasting CAH performed poorer than patients with simple virilizing CAH in a test assessing visuo-spatial working memory (P = 0.039), although the performance was within the normal range for the population. Prenatally DEX-treated girls with CAH had lower verbal intellectual ability compared with CAH girls not exposed to prenatal treatment (P = 0.037).

Conclusion
Children and adolescents with CAH who were diagnosed early via a neonatal screening program and treated with hydrocortisone had normal psychometric intelligence and executive functions.
Mitochondrial Dysfunction and Ovarian Aging
Authors: Kasapoğlu Işıl , Seli Emre 
Published: January 2020

Abstract
As women delay childbearing because of demographic and socioeconomic trends, reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent causes of infertility. Age-related decline in fertility is characterized by both quantitative and qualitative deterioration of the ovarian reserve. Importantly, disorders of aging are frequently associated with mitochondrial dysfunction, as are impaired oogenesis and embryogenesis. Ongoing research explores the role of mitochondrial dysfunction in ovarian aging, and potential ways to exploit mitochondrial mechanisms to slow down or reverse age-related changes in female gonads.
Amhr2-Cre–Mediated Global Tspo Knockout
Authors: Fan Jinjiang , Campioli Enrico , Sottas Chantal , Zirkin Barry , Papadopoulos Vassilios 
Published: January 2020

AbstractAlthough the role of translocator protein (TSPO) in cholesterol transport in steroid-synthesizing cells has been studied extensively, recent studies of TSPO genetic depletion have questioned its role. Amhr2-Cre mice have been used to generate Leydig cell-specific Tspo conditional knockout (cKO) mice. Using the same Cre line, we were unable to generate Tspo cKO mice possibly because of genetic linkage between Tspo and Amhr2 and coexpression of Amhr2-Cre and Tspo in early embryonic development. We found that Amhr2-Cre is expressed during preimplantation stages, resulting in global heterozygous mice (gHE; Amhr2-Cre+/–,Tspo–/+). Two gHE mice were crossed, generating Amhr2-Cre–mediated Tspo global knockout (gKO; Tspo–/–) mice. We found that 33.3% of blastocysts at E3.5 to E4.5 showed normal morphology, whereas 66.7% showed delayed development, which correlates with the expected Mendelian proportions of Tspo+/+ (25%), Tspo–/– (25%), and Tspo+/– (50%) genotypes from crossing 2 Tspo–/+ mice. Adult Tspo gKO mice exhibited disturbances in neutral lipid homeostasis and reduced intratesticular and circulating testosterone levels, but no change in circulating basal corticosterone levels. RNA-sequencing data from mouse adrenal glands and lungs revealed transcriptome changes in response to the loss of TSPO, including changes in several cholesterol-binding and transfer proteins. This study demonstrates that Amhr2-Cre can be used to produce Tspo gKO mice instead of cKO, and can serve as a new global “Cre deleter.” Moreover, our results show that Tspo deletion causes delayed preimplantation embryonic development, alters neutral lipid storage and steroidogenesis, and leads to transcriptome changes that may reflect compensatory mechanisms in response to the loss of function of TSPO.
Use of a smartphone thermometer to monitor thermal conductivity changes in diabetic foot ulcers: a pilot study
Authors: Maddah Erfan , Beigzadeh Borhan 
Published: January 2020

Objective: To investigate the dependability of a thermal gadget connecting to a smartphone. Comparing the exact temperature of damaged tissue with adjacent parts of the limb and to evaluate the changes in thermal conductivity of hard-to-heal wounds in patients with a diabetic foot ulcer (DFU). Methods: Potential candidates were divided into three groups and selected from different hospitals in Tehran. Group 1 contained patients with inflammation, Group 2 were patients with vascular complications, and Group 3 were patients who were managing to control their glucose levels to an acceptable level, according to their medical records (i.e. ‘healthy cases’). All thermal images were taken without any external stimulus, in room temperature conditions after 15 minutes' rest. All medical records were confirmed by therapeutic supervisors. Moreover, the tissue conditions in patients were considered in the computational part of the study. The temperatures of the ulcer and adjacent tissues were observed and compared. The collected data were used in a suggested model for human tissues and the method of calculation in this study was trial and error. In this study, patients in Group 2 were considered in the computational section of the study. Results: Temperature difference between the wounds and adjacent tissues for the big toe in three patients in Group 2 was 2.2ºC for the healthier candidate and almost 6.9ºC in the worst case. By comparing the thermal conductivity of normal and damaged tissues, a significant reduction in thermal conductivity was observed for the candidate with the worst status of big toe by about 84.3%. For the other two candidates in this category, it was almost 68.86% and 20.47%. Conclusion: The variation in thermal conductivity represents the change in tissue properties. Thermal conductivity can be applied for early DFU detection. This data may allow introduction of the smartphone thermometer as an authentic and alternative apparatus that is beneficial in diabetic clinics as well as self-assessment by patients. Moreover, due to the decrease in thermal conductivity, this study suggests using intelligent thermal sheets in vulnerable parts of the diabetic foot.
تَجَلّيات الجرس والإيقاع في آية الكرسيّ
Authors: Ezzat Azza A. , Ahmed Narmeen G. 
Published: January 2020

يعني القرآن الكريم بالجرس والإيقاع ويختار الألفاظ على أساس الموسيقى المتناسقة مع جو الآية والسياق، وللأصوات والمقاطع الصوتيّة جرس خاص وإيقاع متميز يتناغمان مع المعنى والدلالة، ويتغيَّران بتغيير الألفاظ والصيغ والتراكيب، ويكون لذلك أثر كبير في مجموع الأصوات ونسبتها المئوية ودلالتها، فكلُّ تغيير في اللفظ، أو الصيغة يتسبَّب بتغيير صوتيّ أو مقطعيّ، و قد لاحظنا تناغم الكثير من صفات الأصوات مع المعنى كالأصواتُ المجهورة التي شكَّلت نسبة عالية تناسبت وموضوع آية الكرسي، الجهر بالوحدانيّة لله، وتبيان قدرة الله ومشيئته، وقد أسهم في توضيح ذلك صوت اللام بوروده مفخَّما مرَّة واحدة فقط، مقترنا بلفظ الجلالة (الله) في أوَّل الآية وحصل على أعلى نسبة بين أصوات الآية، فللكثرة دلالتها، وللقلّة دلالتها. أمّا إيقاعيّا فقد وردت أصوات العلّة بمعدل ثاني أعلى نسبة بعد صوت اللام مجتمعة، مع اختلاف أطوالها مُدّةً في النطق، وهذا ما يرسم الإيقاع، وكان للتكرار الصوتي موسيقى إيقاعية اقترنت بالمعنى والدلالة كتكرار صائت الألف حصرا في أوّل الآية الذي تناسب والحديث عن وحدانية الله، فضلا عن تكرار الألف في الجمل التي تحدَّثت عن مشيئة الله، وكذلك لوحظ تناوب تكرار صائتي الواو والألف بشكل متعاقب فعكس علاقة السِنة أو النوم بالتعب، وأمّا اجتماع صائتي: الياء والواو في سياق الحديث عن نفي الشفاعة و نفي الإحاطة رسم ربط الشفاعة بالعلم كمرتبة لها ميزتها.
«Эра типичных советских и постсоветских директоров в политике подходит к концу». Интервью
Authors: Белоусов Александр Борисович , Федоров Валерий Валерьевич 
Published: January 2020

В январе 2019 года Лаборатория социально-политических коммуникаций Института философии и права УрО РАН опубликовала в СМИ доклад о ситуации на выборах губернатора Челябинской области. В докладе делался прогноз о вероятном снятии действующего губернатора Бориса Дубровского. Спустя несколько месяцев Дубровский добровольно сложил с себя полномочия губернатора, а Владимир Путин назначил и.о. губернатора Алексея Текслера
За последние годы доклад стал, возможно, единственным исследованием, выполненным в жанре публичной экспертизы, в котором содержался прогноз развития ситуации в регионе. Однако за пределами Урала исследование осталось неизвестным. Главный редактор журнала «Мониторинг общественного мнения» решил поговорить с автором доклада обо всем, что сопровождало его подготовку и публикацию. В первую очередь интересовали потребности в публичной экспертизе, ценности прогностических исследований, проблемы региональных экспертных сообществ и то, какую пользу челябинский кейс может принести в масштабах России.
Pemetaan Sebaran Terumbu Karang Studi Kasus Selat Madura, Jawa Timur
Authors: Hidayah Zainul , Nuzula Nike Ika 
Published: January 2020

Mapping of the potential of coral reefs on the coast of the Madura Strait is evaluated. The coral mapping purposes are to evaluated a total area of the coral reefs in line with the current condition. The index of the area of coral reefs on the coast of the Madura Strait was also compiled to produce a database of the parameters that affect to the coral reefs growths. The imaga data processed is using Landsat. Maping data processing methos is using Lyzinge Algorithm since the area has shallow water area characteristics. The area of coral reef substrate identified according to the processed image is 10.478.032 Ha. The Landsat 7 satellite imagery has an ability to detect the characteristics of shallow waters using blue channels with wavelengths of 0.45-0.52 µm and green channels with wavelengths of 0.52-0.60 µm. However, to determine the condition and how severe the damage to coral reefs, detection with satellite imagery is not enough so that direct observation is needed through scuba diving activities. Scuba diving is carried out to determine the condition of coral reefs. Roughly, coral reef ecosystems in the objects are categorized as moderate to damaged. The damage to this coral reef ecosystem identified at the depths of 5 and 10 meters. Pemetaan potensi terumbu karang dilakukan di area pesisir Selat Madura. Pemetaan ini dilukan dengan memanfaatkan data citra satelit dari Landsat 7 dan pengolahan data menggunakan metode Algoritma Lyzinge. Studi ini bertujuan untuk mengetahui cakupan luas dari sebaran terumbu karang serta kondisi terumbu karang. Indeks dari area terumbu karang dipetakan dan disusun untuk selanjutkan digunakan sebagai basis data yang berisi tentang informasi yang mengadung parameter – parameter yang berpengaruh terhadap pertumbuhan terumbu karang. Dalam penelitian ini, terumbu karang ditemukan di perairan dangkal yang jernih. Citra satelit Landsat 7 memiliki sensor yang dapat mendeteksi karakteristik perairan dangkal dengan memanfaatkan saluran/ kanal biru dengan panjang gelombang 0,45-0,52 µm dan saluran/ kanal hijau dengan panjang gelombang 0,52-0,60 µm. Namun, untuk mengetahui kondisi dan tingkat kerusakan terumbu karang, pendeteksian dengan citra satelit tidaklah cukup sehingga diperlukan pengamatan secara langsung melalui aktivitas penyelaman scuba. Hasil yang diperoleh dari penelitian ini adalah luas substrat terumbu karang adalah 10,478.032 Ha. Hasil dari scuba diving menunjukkan bahwa secra umum ekosistem terumbu karang di perairan Selat Madura berada dalam kondisi sedang hingga rusak. Kerusakan ekosistem terumbu karang ini terjadi pada kedalaman 5 dan 10 meter.
Fluktuasi Fitoplankton pada Kawasan Konservasi Rajungan Perairan Betahwalang Demak
Authors: Agus Elsa Lusia , Pribadi Rudhi , Subagiyo Subagiyo 
Published: January 2020

Phytoplankton is an organism that had an effect on life waters and can be used as the parameters in monitoring water quality. Distribution of phytoplankton in the waters can be for biomonitoring which can be used to make protection zone. This study will examine the distribution and composition of phytoplankton in The crab conservation area in Betahwalang Waters, Demak. This research divided into three stations in estuaries and the sea s. Each sampling was done once a month. Samples were taken using a plankton net. The results found three classes of phytoplankton, namely Bacillariophyceae class, Cyanophyceae class and Dinophyceae class. The number of genera found in the river area (37 genera), at the estuary station as much (38 genera) and the sea station as much (31 genera). Fluctuation in phytoplankton abundance at each station is quite varied. The abundance of phytoplankton in January was 1.030.400 cells/L, in February it was 936.800 cells/L, and in March it was 643.600 cells/L. The highest abundance occurs in the estuary area, then the river and the lowest in the sea. The value of species diversity index (H ') is in the range of 2.57-3.03. Uniformity index values range from 0.86 to 0.94. The dominance index from 0.06 to 0.14. Factors affecting the abundance and dominance of phytoplankton are water conditions and the rainy season. Fitoplankton merupakan organisme yang mempunyai pengaruh besar terhadap kehidupan di suatu perairan baik langsung maupun tidak langsung dan dijadikan sebagai salah satu parameter dalam pemantauan kualitas perairan.Fitoplankton di perairan dapat dijadikan suatu ukuran bahwa Kawasan tersebut dapat dijadikan sebagai zona perlindungan biota.Penelitian ini mengkaji fluktuasi fitolankton pada Kawasan konservasi rajungan di Perairan Betahwalang, Demak. Penelitian ini dilakukan pada 3 stasiun yang terletak disungai, muara sungai, dan laut. Pengambilan sampel dilakukan setiap bulan selama tiga bulan menggunakan planktonnet. Hasil penelitian ditemukan 3 kelas yaitu kelas Bacillariophyceae, Cyanophyceae dan Dinophyceae.Jumlah genus yang ditemukan pada area sungai, muara sungai dan laut berturut-turut 37 genus, 38 genus dan 31 genus. Fluktuasi kelimpahan fitoplankton di setiap stasiun cukup bervariasi.Kelimpahan fitoplankton pada bulan Januari sebesar 1.030.400 sel/L, pada bulan Februari sebesar 936.800 sel/L, dan pada bulan Maret sebesar 643.600 sel/L. Kelimpahan tertinggi terjadi pada daerah muara, kemudian sungai dan terendah di laut. Sedangkan nilai indeks keanekaragaman jenis (H’) berada pada kisaran 2,57-3,03. Nilai indeks keseragaman berkisar 0,86-0,94. Sedangkan indeks dominasi berkisar 0,06-0,14. Faktor yang mempengaruhi kelimpahan dan dominasi fitoplankton adalah kondisi perairan dan musim hujan.
Vliv procvičování na Khan Academy na znalosti a dovednosti žáků v matematice
Authors: Vančura Jiří 
Published: January 2020

Ve dvou předkládaných kvantitativních studiích jsme zkoumali vliv procvičování učiva matematiky pomocí interaktivní sbírky úloh Khan Academy na znalosti a dovednosti žáků čtyřletého gymnázia. V první studii z roku 2016/17 jsme se zaměřili na přenos naučených procedurálních znalostí a dovedností z anglického prostředí Khan Academy do českého školního kontextu. Ve druhé studii z roku 2017/18 jsme se věnovali otázce rozvoje konceptuálních znalostí skrze procvičování procedurálních dovedností. Obě studie probíhaly na stejném vzorku 44 žáků ze dvou tříd pražského gymnázia. Data jsme analyzovali pomocí testování hypotéz s hladinou spolehlivosti 5 %. Autor studií byl v době výzkumu učitelem matematiky těchto žáků. Zatímco v první studii byl přínos procvičování statisticky významný, ve druhé studii nebyl rozvoj konceptuálních znalostí žáků tak jednoznačný. Sekundárně jsme se věnovali žákovskému vnímání vlivu Khan Academy na jejich znalosti a dovednosti.