bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft tissue tumours of the elbow: current concepts
Authors: Savvidou Olga D. , Koutsouradis Panagiotis , Bolia Ioanna K. , Kaspiris Angelos , Chloros George D. , Papagelopoulos Panayiotis J. 
Published: December 2019

Soft tissue tumours of the elbow are mostly benign. Malignant tumours in this area, although uncommon, often present unique clinical and histopathological characteristics that are helpful for diagnosis. Management of soft tissue tumours around the elbow may be challenging because of their rarity and the proximity to neurovascular structures. Careful staging, histological diagnosis and treatment are essential to optimize clinical outcome. A missed or delayed diagnosis or an improperly executed biopsy may have devastating consequences for the patient. This article reviews the most common benign and malignant soft tissue tumours of the elbow and discusses the clinicopathological findings, imaging features and current therapeutic concepts.Cite this article: EFORT Open Rev 2019;4:668-677. DOI: 10.1302/2058-5241.4.190002
Campus USP Butantã: el conocimiento crítico y la ciudad
Authors: Sandoval Gregori Marcia , Guilherme Mota Carlos 
Published: December 2019

El estudio tiene como objetivo determinar cómo la relación espacial de la Ciudad Universitária Armandobr /Salles de Oliveira (Campus Butantã de la Universidad de São Paulo) con la ciudad expresa una segregación que ahora presenta matices diferentes a la época de su creación. Concebida para ser una entidad autónoma, independiente, destinada al desarrollo del conocimiento, lejos del centro urbano, actualmente, con el crecimiento de la ciudad, se ha incorporado a la trama de São Paulo. Sin embargo, aún aparece como un espacio segregado de la ciudad, aunque con diversas interpenetraciones mutuas. La creación de la Ciudad Universitaria muestra la distinción del conocimiento universitario como la representación de una ciudad técnico-industrial y de un país desarrollado. Además de las formas físicas y espaciales, su ubicación, su disposición espacial y su relación con la ciudad expresan las representaciones de la sociedad, de las mentalidades. Hoy rodeada por la ciudad con todos sus problemas y peculiaridades, la Ciudad Universitaria exhibe una situación urbana que remite a algunas ideas “condominiales” como modo de aislarse del entorno. Con su propio estilo de vida, basado en un orden interno particular y en la convivencia entre semejantes, el campus Butantã USP, busca, por un lado, evitar los conflictos de la ciudad a su alrededor, al mismo tiempo que no puede evitar formar parte de ella. Es una invitación a reflexionar sobre las premisas y motivos de la concepción de ese formato, cómo se desarrolla y cuáles son sus marcas en la relación universidad-ciudad y universidad-sociedad.
Sistema sindical italiano: la evolución que le faltó a Brasil
Authors: Bonatto Barcellos Antonio Augusto , Zambrano Virginia 
Published: December 2019

El presente trabajo trata sobre la constatación de la distinta evolución que tuvieron los sistemas sindicales brasileño e italiano durante el siglo XX. A partir de un modelo muy similar en el período anterior a la Segunda Guerra Mundial, Italia adoptó un sistema sindical que respetaba los postulados de libertad sindical plena. Incluso a pesar de todas las dificultadas causadas por la difícil adaptación de las relaciones de trabajo al nuevo sistema, Italia ya posee más de medio siglo de constantes cambios en busca del respeto a la libertad sindical. Brasil tarde o temprano tendrá que adoptar el mismo sistema y parece que la inspiración del modelo italiano le puede ser muy útil.
P047 Do People With History of Inflammatory Disease Have a Higher Risk for Acute Coronary Syndrome
Authors: Al-Abboodi Yasir , Kubaissy Abdullah , Ali Ali Muhammed 
Published: December 2019

BACKGROUND:
There is a debate if patients with history of inflammatory bowel disease (IBD) have higher risk of having acute coronary syndromes (ACS). Several studies have not answered this question. Our study used national data registry called the National Inpatient Sample (NIS) and the size of the target population is the largest sample used to answer the aforementioned question.

METHODS:
Retrospective analysis for the national inpatient sample data base (NIS). All diagnoses including IBD, ACS, Hypertension (HTN), Diabetes mellites (DM), Smoking, obesity, Alcohol abuse were identified using International Statistical Classification of Diseases and Related Health Problems (ICD9). A univariate and multivariate logistic regression analysis were used to calculate the Odd ratio. T test was used to examine the means. SPSS software version 24 was used for analysis.

RESULTS:
57984 admissions with history of inflammatory bowel disease (IBD) were identified using ICD9 codes. Of those, 7894 had Ulcerative colitis (UC), 40628 with Crohn’s, 414 (.0.7%) had acute coronary syndromes (ACS) related admissions. Mean age of patients is 50 plus. 25209 (43.5%) male, 32762 (56.5%) female. 47144 (81.3%) White, 5889 (10.2%) Black, 2941 (5.1%) Hispanic, 523 (0.9%) Asians, 1251 (2.2%) others. Mean length of stay for patient who had ACS related admissions and history of IBD is 5.4 days vs. 4.4 days for people without history of IBD (P = 0.08). A multivariate logistic regression showed that. Patients with history of IBD is less likely to have ACS(P < 000, Odd ratio(OR) = 0.73, 95% confidence interval (CI) = 0.0.669–0.0812 ), Smoking, (P < 0.05, OR = 1.569, 95% CI = 1.540–1.600), HTN (P < 0.005, OR = 2.732, 95% CI = 2.689–2.777), DM (P < 0.005, OR = 1.468, 95% CI = 0.428–1.508), Alcohol abuse (P < 0.05, OR = 0585, 95% CI = 0.56–0.611). There is no inpatient mortality difference between ACS related admission with history of IBD vs people with no history of IBD (P = 0.535, OR = 0.643, 95% CI = 1.60–2.588).

CONCLUSION(S):
People with inflammatory bowel disease do not have a higher risk for acute coronary syndrome. There is no mortality difference between ACS related admission with or without history of inflammatory bowel disease. ACS related admission with history of inflammatory bowel disease has a longer length of stay but not statistically significant.
P108 Serum Vedolizumab and Anti-Vedolizumab Antibody: Analysis of 6500 Patient Results Using Lab Developed Electrochemiluminescent Immunoassays (ECLIA)
Authors: Chun Kelly , Yang Jane 
Published: December 2019

BACKGROUND:
Vedolizumab (VDZ), an anti- α4b7 integrin monoclonal antibody, is indicated for moderate to severe ulcerative colitis and Crohn’s disease. Therapeutic drug monitoring (TDM) assays to measure VDZ and anti-vedolizumab drug antibodies (ADAb) in patient serum are utilized to manage lack or loss of response and to proactively optimize dosing. Some studies suggest target induction trough concentrations >30 ug/mL and maintenance troughs > 14 ug/mL (1,2). Here, 6500 VDZ patient results were analyzed.

METHODS:
Measurements of VDZ drug (free, ADAb-unbound) and anti-vedolizumab antibody (total including IgM and IgG subtypes) were performed by lab-developed ECLIA. Lower limits of quantitation are 1.5 ug/mL for VDZ and 25 ng/mL for ADAb. All ADAb positive samples are confirmed by a signal suppression test. Clinical histories and blood collection timing are unknown.

RESULTS:
Of 6500 measured samples, 98.9% (6426) were ADAb-free and only 1.1% (74) had measurable anti-vedolizumab antibodies. Since VDZ TDM was launched in January 2017, volumes have been increasing rapidly. In the absence of ADAb, the median VDZ concentration was 16.0 ug/mL with a range of 1.5 to 389 ug/mL. The distribution of 6426 VDC concentration measurements was as follows: 4.5% of patient samples had undetectable VDZ (<1.5 ug/mL) and 14.3% were less than 5.0 ug/mL. Of note, almost half of all VDZ concentrations (48.3%, 3101 or 6426) were less than 15 ug/mL. Only 30.6% (1966) of measured concentrations fell between 15 and 30 ug/mL, and 21.1% (1358) were greater than 30 ug/mL. Only 74 of 6500 samples had measurable anti-vedolizumab antibodies ranging in titer from 25 to 18,556 ng/mL. In the presence of high ADAb titers (>1000 ng/mL), concomitant VDZ drug levels were very low or undetectable (mean < 1.5 ug/mL, ranging from <1.5 to 8.8). In the setting of intermediate (100 - 1000 ng/mL) and low (<100 ng/mL) titers, the concomitant free drug mean was 6.9 and 16.1 ug/mL, respectively.

CONCLUSION(S):
Here, 6500 samples for VDZ monitoring were analyzed. The immunogenicity rate was low at 1.1%. Of our 6426 ADAb negative samples, ∼ 30% had VDZ levels 15 – 30 ug/mL and ∼20% were above 30 ug/mL. Interestingly, almost half (48.3%) of all VDZ measurements were less than 15 ug/mL. If 15 is considered a therapeutic cutoff, these findings may indicate a significant incidence of subtherapeutic VDZ. Despite the lack of firmly established targets, gastroenterologists are increasingly using TDM during both induction and maintenance to assess vedolizumab exposure.
Estilos parentais e comportamentos de bullyingem adolescentes e jovens adultos: Efeito moderador da personalidade
Authors: Mota Catarina Pinheiro , Costa Mónica , Pinheiro Mónica , Nunes Filipa 
Published: December 2019

Os estilos parentais caracterizam a natureza afetiva e a relação entre os pais e os filhos, apresentando por isso, uma contribuição importante para o desenvolvimento psicossocial dos jovens. A vivência familiar, a relação mantida com os pares e o desenvolvimento do adolescente contribuem para a formação da sua personalidade, sendo esta que dita muitos dos comportamentos futuros dos adolescentes e jovens adultos. Este estudo teve como objetivo analisar o papel dos estilos parentais e da personalidade no desenvolvimento de comportamentos de agressão e vitimação, assim como, testar o papel moderador da personalidade na associação anterior. A amostra foi constituída por 1976 adolescentes e jovens adultos, com idades compreendidas entre os 14 e os 25 anos de idade (M=17.22; DP=2.50). A recolha de dados foi realizada com recurso a instrumentos de autorrelato. Os resultados sugerem a extroversão e a conscienciosidade como fatores protetores face ao desenvolvimento de comportamentos de vitimação e agressão, e o neuroticismo como um importante potenciador destes comportamentos. Os dados foram analisados à luz da teoria de Baumrind, assumindo a importância dos estilos parentais para o desenvolvimento da personalidade e de comportamentos de bullying na adolescência e jovem adultícia.
The Effect of Cu Ohmic Contact on Photoelectrochemical Property of S-CuO Thin Film Photocathodes
Authors: Amrullah Aziz , Gunawan Gunawan , Prasetya Nor Basid Adiwibawa 
Published: December 2019

The development of semiconductor materials as photocathodes that have excellent performance is significant for the photoelectrochemical reaction of hydrogen evolution. The thin film of sulfur-doped Copper (II) oxide (S-CuO) was successfully synthesized using the cyclic voltammetry method. Investigation of photoelectrochemical properties of S-CuO photocathodes, including current density, onset potential, applied photon to current efficiency (ABPE), and bandgap had been carried out. It was reported that the Cu ohmic contact affected the photoelectrochemical properties and the stability of the thin film. The presence of Cu ohmic contact can improve the performance of S-CuO thin film photocathodes. The S-CuO TU 20 mM thin film has the best response with a current density of -0.923 mA/cm2, an onset potential of 0.59 V, and ABPE of 0.21%. Stability occurred at pH 7 in 0.2M NaH2PO4. The optical analysis showed S-CuO TU 20 mM bandgap of 1.7 eV.
Detektion von Anomalien zur Qualitätssicherung basierend auf Sequence-to-Sequence LSTM Netzen
Authors: Lindemann Benjamin , Jazdi Nasser , Weyrich Michael 
Published: December 2019

Zusammenfassung
Unvorhersehbare Prozessereignisse und Anomalien sind Treiber erhöhter Ineffizienzen in Form von schwankender Produktqualität. In diesem Beitrag wird ein datengetriebener Ansatz zur Qualitätsoptimierung vorgestellt, auf dessen Basis Anomalien charakterisiert werden, die zur Entwurfszeit des Systems nicht bekannt waren. Es wird eine Netzarchitektur in Form eines Sequence-to-Sequence Netzes mit Long Short-Term Memory (LSTM) Zellen vorgestellt. Dadurch kann vorhergesagt werden, welche Anpassung am Stellgrößenverhalten vorgenommen werden muss, um erwartete Anomalien zu kompensieren. Dadurch wird das Qualitätsergebnis langfristig in der Toleranz gehalten. Der Ansatz wird prototypisch anhand von zwei Prozessketten der diskreten Fertigung umgesetzt und evaluiert.
The Challenge of Organizing Elderly Care Programmes: Optimal Policy Design under Complete and Asymmetric Information
Authors: Leporatti Lucia , Montefiori Marcello 
Published: December 2019

Abstract
The increasing life expectancy poses challenges on the future sustainability of long-term care services that today strongly depend on informal care provided within the family by working age children. Ongoing social changes are likely to weaken the informal provision of care. The paper derives optimal policies to help the policy-maker to choose innovative and sustainable solutions to support home care, taking into account the severity of health condition and the different opportunity costs of carers. Drawing inspiration from real world policies, the suitable policy combines lump-sum transfers, paid permissions from work and in-kind provisions. In some circumstances, benefits can favour higher rather than lower income individuals. In the context of information asymmetry, the implementation of the second-best outcome requires the level of care of the most subsidized households’ to be forced towards certain targets to avoid adverse selection.
Wireless power transmission in endoscopy capsules
Authors: Kühne Michael , Andrä Wilfried , Werner Christoph , Bellemann Matthias E. 
Published: December 2019

Abstract
The operating life of endoscopy capsules is limited by the batteries needed for use. The capacity of corresponding batteries, however, is too short to cover the total period of gastrointestinal transit. To overcome this limitation, a novel kind of wireless power transmission was used. It utilizes a permanent magnetic cylinder located outside the patient’s body and is turned by an electric motor, thereby generating a rotating magnetic field. This field in turn causes the motor, by a permanent magnetic sphere, located in a liquid bearing inside the endoscopy capsule, to rotate synchronously. The sphere induces an alternating voltage in coils inside the capsule and thus provides the necessary power. This arrangement was able to transmit power of up to 170 mW. This value is clearly higher than the minimum power of 100 mW needed to operate the electronics of the endoscopy capsules that are actually in use. The volume of both the sphere and the induction coil is smaller than the batteries that are actually integrated in the capsules. By this means, the operating time may be prolonged, in principle up to arbitrary values.
Synthesis and crystal structure of benzyl 5-oxo-5-phenyl-2-(quinolin-2-yl)pentanoate, C27H23NO3
Authors: Wang Li , An Xiao-Xin , Cui Yong-Fan , Dong Wen-Kui 
Published: December 2019

Abstract
C27H23NO3, monoclinic, P21 (no. 4), a = 5.8236(4) Å, b = 16.7277(13) Å, c = 10.5963(7) Å, β = 96.022(2)°, V = 1026.55(13) Å3, Z = 2, R
gt(F) = 0.0396, wR
ref(F
2) = 0.0953, T = 153(2) K.
Characterization of Embryonic Skin Transcriptome in Anser cygnoides at Three Feather Follicles Developmental Stages
Authors: Liu Chang , Sello Cornelius Tlotliso , Sui Yujian , Hu Jingtao , Chen Shaokang , Msuthwana Petunia , Zhou Yuxuan , Wachiebine Sulleyman Kassim , Sun Yue , Liu Jing , Li Shengyi , Yang Wei , Song Yupu , Xu Yunpeng , Guo Chanying , Sui Qihui , Sun Yongfeng 
Published: December 2019

Abstract
In order to enrich the Anser cygnoides genome and identify the gene expression profiles of primary and secondary feather follicles development, de novo transcriptome assembly of skin tissues was established by analyzing three developmental stages at embryonic day 14, 18, and 28 (E14, E18, E28). Sequencing output generated 436,730,608 clean reads from nine libraries and de novo assembled into 56,301 unigenes. There were 2,298, 9,423 and 12,559 unigenes showing differential expression in three stages respectively. Furthermore, differentially expressed genes (DEGs) were functionally classified according to genes ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and series-cluster analysis. Relevant specific GO terms such as epithelium development, regulation of keratinocyte proliferation, morphogenesis of an epithelium were identified. In all, 15,144 DEGs were clustered into eight profiles with distinct expression patterns and 2,424 DEGs were assigned to 198 KEGG pathways. Skin development related pathways (mitogen-activated protein kinase signaling pathway, extra-cellular matrix -receptor interaction, Wingless-type signaling pathway) and genes (delta like canonical Notch ligand 1, fibroblast growth factor 2, Snail family transcriptional repressor 2, bone morphogenetic protein 6, polo like kinase 1) were identified, and eight DEGs were selected to verify the reliability of transcriptome results by real-time quantitative PCR. The findings of this study will provide the key insights into the complicated molecular mechanism and breeding techniques underlying the developmental characteristics of skin and feather follicles in Anser cygnoides.
The Alliance of Genome Resources: Building a Modern Data Ecosystem for Model Organism Databases
Authors:   The Alliance of Genome Resources Consortium
Published: December 2019

Abstract
Model organisms are essential experimental platforms for discovering gene functions, defining protein and genetic networks, uncovering functional consequences of human genome variation, and for modeling human disease. For decades, researchers who use model organisms have relied on Model Organism Databases (MODs) and the Gene Ontology Consortium (GOC) for expertly curated annotations, and for access to integrated genomic and biological information obtained from the scientific literature and public data archives. Through the development and enforcement of data and semantic standards, these genome resources provide rapid access to the collected knowledge of model organisms in human readable and computation-ready formats that would otherwise require countless hours for individual researchers to assemble on their own. Since their inception, the MODs for the predominant biomedical model organisms [Mus sp. (laboratory mouse), Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Danio rerio, and Rattus norvegicus] along with the GOC have operated as a network of independent, highly collaborative genome resources. In 2016, these six MODs and the GOC joined forces as the Alliance of Genome Resources (the Alliance). By implementing shared programmatic access methods and data-specific web pages with a unified “look and feel,” the Alliance is tackling barriers that have limited the ability of researchers to easily compare common data types and annotations across model organisms. To adapt to the rapidly changing landscape for evaluating and funding core data resources, the Alliance is building a modern, extensible, and operationally efficient “knowledge commons” for model organisms using shared, modular infrastructure.
Características clínicas y mortalidad intrahospitalaria en pacientes con insuficiencia renal aguda en hemodiálisis, en el Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, 2014-2015
Authors: Fernandez-Burga Antonio , Briceño-Santillan Kristhian , Mejia Christian R. 
Published: December 2019

Introducción: No existen datos oficiales sobre los pacientes con insuficiencia renal aguda (IRA) en el Perú. La mayor parte de la información proviene de centros aislados en otros países. Objetivo: Describir las características clínicas y la mortalidad intrahospitalaria en pacientes con insuficiencia renal aguda, en hemodiálisis, atendidos en un hospital de tercer nivel del Perú. Método: Estudio transversal, realizado en pacientes con diagnóstico de IRA en hemodiálisis, atendidos en el Hospital Guillermo Almenara Irigoyen, EsSalud, durante 2014-2015. Se evaluaron las características clínicas generales y se estimó la tasa de mortalidad intrahospitalaria. Resultados: Se evaluaron 183 pacientes. La edad media fue de 58 años y el 57% fueron varones. El 90% ingresaron al hospital a través de emergencia (EMG). Los pacientes fueron admitidos en la unidad de cuidados intensivos (UCI), EMG y otras áreas de hospitalización en el 40%, 27% y 33% de los casos, respectivamente. Las causas más frecuentes de IRA fueron: sepsis (59%), insuficiencia cardíaca (8%) y uropatía obstructiva (7%). La mortalidad intrahospitalaria fue de 55% (n=100). Los pacientes fallecidos mostraron una mayor frecuencia de sepsis (71 vs. 38; p = 0,001) y de compromiso multiorgánico (90 vs. 56; p < 0,001) en comparación con los vivos. Conclusiones: Los pacientes con IRA tuvieron una edad media de 59 años y la mayoría estuvieron hospitalizados en UCI. La causa más frecuente de IRA fue la sepsis. La mortalidad intrahospitalaria fue 55% y estuvo significativamente asociada a la presencia de sepsis y compromiso multiorgánico.
Frecuencia de trastornos musculoesqueléticos en los trabajadores de una refinería de Lima, 2017
Authors: Ramírez-Pozo Egle Guisela , Montalvo Luna Mery 
Published: December 2019

Introducción: Se estima que los trastornos musculoesqueléticos representan la patología más frecuente en trabajadores y es la causa de mayor cantidad de días no laborados por incapacidad. Objetivo: Determinar la frecuencia de trastornos musculoesqueléticos en los trabajadores de una refinería de Lima durante el año 2017. Métodos: Estudio transversal. Se realizó la revisión de las historias clínicas ocupacionales de los trabajadores para obtener los datos demográficos y el registro donde se emitió el diagnóstico de trastorno musculoesquelético en base a los resultados de pruebas de imagen y de la evaluación clínica realizada por un especialista. Resultados: La muestra incluyó a 223 trabajadores y se encontró una frecuencia de trastornos musculoesqueléticos del 52,9%. Los más frecuentes fueron: lumbago asociado a hernia discal (25,1%), lumbago (13%), síndrome del manguito rotador (10,3%) y cervicalgia asociada a hernia discal (3,6%). Conclusiones: Se encuentra en esta población una elevada prevalencia de trastornos musculoesqueléticos en tronco y extremidades superiores.
Fístula bronquioesofágica asociada a reflujo gastroesofágico
Authors: Padilla Flores Juan Roberto , Lira Villasante Daniel Alcides , Victorio Avila Cesar Antonio , Quispe Huachaca Jhonathan Percy 
Published: December 2019

Se presenta un caso clínico demostrativo de fistula broncoesofágica asociado a reflujo gastroesofágico en un varón de 76 años con diagnóstico de reflujo gastroesofágico y hernia hiatal, que acude por episodios de tos de 1 año de evolución sin respuesta a tratamientos. Demostraremos la utilidad del estudio esofagográfico como elemento diagnóstico. Se revisa brevemente los aspectos clínicos, diagnósticos, terapéuticos y probable secuencia de desarrollo de esta complicación.
Estrategias para promover la alfabetización en salud desde la atención primaria: una perspectiva que considera las realidades de los países de ingresos medios y bajos
Authors: Málaga German , Cuba-Fuentes María Sofía , Rojas-Mezarina Leonardo , Romero-Albino Zoila , Hamb Alexandra , Paz-Soldán Valerie A. 
Published: December 2019

La alfabetización en salud se asocia con mejores resultados de salud. Los profesionales de salud de atención primaria generalmente brindan la mayor parte de la atención a los pacientes y también suelen ser el primer punto de contacto para los pacientes dentro de un sistema de salud. En este artículo se discuten cuatro estrategias para promover la alfabetización en salud en el entorno de atención primaria: 1) Mejorar las habilidades de comunicación del clínico, 2) Usar herramientas de e-Salud, 3) Promover el autocuidado del paciente, y 4) Desarrollar sistemas de apoyo y entornos de cuidado. Estas estrategias se discuten en el contexto de las realidades de los países de ingresos medios y bajos, como el caso de Perú.