bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three‐dimensional Yarnball k‐space acquisition for accelerated MRI
Authors: Stobbe Robert W. , Beaulieu Christian 
Published: October 2020

PurposeTo introduce an efficient sampling technique named Yarnball, which may serve as a direct alternative to 3D Cones.MethodsYarnball evolves through 3D k‐space with increasing loop size, and the differential equations defining this flexible trajectory are presented in detail. The sampling efficiencies of Yarnball and 3D Cones were compared through point spread function analysis and simulated imaging (which highlights undersampling in the absence of other scanning effects). The feasibility of Yarnball implementation was demonstrated for fully sampled T1‐weighted images of the human head at 3 T.ResultsThe mostly large 3D loops of the Yarnball trajectory facilitate rapid sampling under peripheral nerve stimulation constraint, an advantage that increases with readout duration (TRO). Point spread function analysis yielded 89% (TRO = 2 ms) and 77% (TRO = 10 ms) of Yarnball voxels with magnitude less than 0.01% of the point spread function peak. For 3D Cones, these values were only 52% and 29%. The 3D‐Cones technique required 1.4 times (TRO = 2 ms) and 1.8 times (TRO = 10 ms) more trajectories than Yarnball to produce simulated images of a sphere free from undersampling artifact. For a prolate spheroidal (head‐like) object, 1.75 times and 2.6 times more trajectories were required for 3D Cones. Yarnball produced 0.72 mm (1/2kmax) isotropic T1‐weighted human brain images free from undersampling artifact in only 98 seconds at 3 T.ConclusionYarnball demonstrated greater k‐space sampling efficiency than directly comparable 3D Cones, and may have value wherever 3D Cones has been considered. Yarnball may also have value in the context of rapid T1‐weighted brain imaging.
Data‐driven research in retail operations—A review
Authors: Qi Meng , Mak Ho‐Yin , Shen Zuo‐Jun Max 
Published: October 2020

AbstractWe review the operations research/management science literature on data‐driven methods in retail operations. This line of work has grown rapidly in recent years, thanks to the availability of high‐quality data, improvements in computing hardware, and parallel developments in machine learning methodologies. We survey state‐of‐the‐art studies in three core aspects of retail operations—assortment optimization, order fulfillment, and inventory management. We then conclude the paper by pointing out some interesting future research possibilities for our community.
Nursing work environment, professional self‐actualization and marketing of the nursing profession: Cross‐sectional study
Authors: Hazanov Yelena , Gehman Yulia , Wilf Miron Rachel , Kagan Ilya 
Published: October 2020

AbstractAimTo explore associations between nurses' sense of professional self‐actualization, nursing work environment and their involvement in promotion and marketing of the nursing profession.DesignA descriptive cross‐sectional study.Methods144 nurses from various clinical fields completed a promotion and marketing activity questionnaire, selected items from the Brief Index of Self‐Actualization and a part of the Revised Nursing Work Index.ResultsNurses' perception of their work environment and holding a master's degree in nursing were associated with their involvement in promotion activities [R2 = 0.27, F(4, 113) = 10.4, p < .001]. Nurses' perception of their work environment was associated with their sense of professional self‐actualization [R2 = 0.21, F(2, 121) = 16.5, p < .001]. Nurses' sense of professional self‐actualization did not contribute to the explanation of variance in their involvement in promotion of the nursing profession.
Multicenter Phase II Trial of Axitinib Monotherapy for Gemcitabine-Based Chemotherapy Refractory Advanced Biliary Tract Cancer (AX-BC Study)
Authors: Okano Naohiro , Furuse Junji , Ueno Makoto , Morizane Chigusa , Yamanaka Takeharu , Ojima Hidenori , Ozaka Masato , Sasaki Mitsuhito , Takahara Naminatsu , Nakai Yousuke , Kobayashi Satoshi , Morimoto Manabu , Hosoi Hiroko , Maeno Satoko , Nagashima Fumio , Ikeda Masafumi , Okusaka Takuji 
Published: October 2020

Abstract

Lessons Learned
Axitinib exhibited marginal activity against gemcitabine-refractory unselected biliary tract cancer. Pretreated soluble vascular endothelial growth factor receptor-2 may be a useful biomarker for axitinib treatment outcome. Ascites should be carefully monitored in patients receiving anti–vascular endothelial growth factor receptor therapy including axitinib in advanced biliary tract cancer.

Background
There are no clear options for second-line treatment in patients with gemcitabine (GEM)-refractory biliary tract cancer (BTC). We conducted a multicenter, single-arm, phase II trial to confirm the efficacy and safety of axitinib, a potent selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-1/2/3, in patients with GEM-refractory BTC.

Methods
Patients refractory or intolerant to GEM-based chemotherapy were enrolled. Axitinib was administered orally at an initial dose of 5 mg twice daily. The primary endpoint was progression-free survival (PFS), and the threshold and expected values were set at 2 and 3 months, respectively. The target sample size was 32 patients.

Results
Nineteen patients were enrolled. The trial was interrupted for a total of 13 months for the evaluation of adverse events. Thirteen patients were previously treated with ≥2 regimens. The median PFS was 2.8 months (95% confidence interval [CI]: 2.1–4.1). The median overall survival was 5.8 months (95% CI: 3.3–9.7). The response rate was 5.3% (95% CI: 0.0–15.3). Grade 3 ascites occurred in two patients. Baseline soluble VEGFR-2 levels were significantly associated with PFS.

Conclusion
Axitinib exhibited marginal activity against GEM-refractory BTC. Ascites should be carefully monitored in axitinib-treated patients with advanced BTC.
Executive function in individuals with clinically significant weight loss via behavioral intervention
Authors: Gowey Marissa A. , Neumeier William H. , Henry Samantha , Wadley Virginia G. , Phillips Janice , Hayden Kathleen M. , Espeland Mark A. , Coday Mace , Lewis Cora E. , Dutton Gareth R. 
Published: October 2020

AbstractBackgroundExecutive function (EF) is associated with obesity development and self‐management. Individuals who demonstrate or self‐report poorer EF performance tend to have poorer short‐term outcomes in obesity treatment. There may be distinct behavioral self‐management strategies and EF domains related to initial weight loss as compared to weight loss maintenance.ObjectiveTo characterize EF in individuals who achieved clinically significant weight loss via behavioral intervention and examine potential differences in EF between those who maintained versus regained lost weight.MethodsParticipants who previously achieved ≥5% weight loss via lifestyle intervention were included (N = 44). “Maintainers” (n = 16) maintained this minimum level of weight loss for ≥1 year. “Regainers” (n = 28) regained some or all initially lost weight. Performance‐based EF, intelligence quotient, health literacy, depression, anxiety, binge eating, demographics, and medical/weight history were assessed using a cross‐sectional design. Descriptive statistics and age‐, gender‐, education‐adjusted reference ranges were used to characterize EF. Analyses of covariance were conducted to examine EF differences between maintainers and regainers.ResultsThe sample consisted primarily of females with obesity over age 50. Approximately half self‐identified as African–American. Decision‐making performance was better in maintainers than regainers (p = 0.003, partη2 = 0.19). There were no differences between maintainers and regainers in inhibitory control, verbal fluency, planning/organization, cognitive flexibility, or working memory (ps > 0.05, partη2s = 0.003–0.07). At least 75% of the sample demonstrated average‐above average EF test performance, indicated by scaled scores ≥13 or t‐scores > 60.ConclusionsMost individuals with obesity who achieved clinically significant weight loss via behavioral intervention had average to above average EF. Individuals who maintained (vs. regained) their lost weight performed better on tests of decision‐making.
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2
Authors: Liu Qiuli , Pang Jian , Wang Lin‐ang , Huang Zhuowei , Xu Jing , Yang Xingxia , Xie Qiubo , Huang Yiqiang , Tang Tang , Tong Dali , Liu Gaolei , Wang Luofu , Zhang Dianzheng , Ma Qiang , Xiao Hualiang , Lan Weihua , Qin Jun , Jiang Jun 
Published: October 2020

AbstractNeuroendocrine prostate cancer (NEPC) is a more aggressive subtype of castration‐resistant prostate cancer (CRPC). Although it is well established that PHF8 can enhance prostate cancer cell proliferation, whether PHF8 is involved in prostate cancer initiation and progression is relatively unclear. By comparing the transgenic adenocarcinoma of the mouse prostate (TRAMP) mice with or without Phf8 knockout, we systemically examined the role of PHF8 in prostate cancer development. We found that PHF8 plays a minimum role in initiation and progression of adenocarcinoma. However, PHF8 is essential for NEPC because not only is PHF8 highly expressed in NEPC but also animals without Phf8 failed to develop NEPC. Mechanistically, PHF8 transcriptionally upregulates FOXA2 by demethylating and removing the repressive histone markers on the promoter region of the FOXA2 gene, and the upregulated FOXA2 subsequently regulates the expression of genes involved in NEPC development. Since both PHF8 and FOXA2 are highly expressed in NEPC tissues from patients or patient‐derived xenografts, the levels of PHF8 and FOXA2 can either individually or in combination serve as NEPC biomarkers and targeting either PHF8 or FOXA2 could be potential therapeutic strategies for NEPC treatment. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
Bedside to bench Alport syndrome research: are human urine‐derived podocytes the answer?†
Authors: Kim Jin‐Ju , Fornoni Alessia 
Published: October 2020

AbstractIn a recent issue of The Journal of Pathology, Iampietro et al isolated and characterized several clones of urine‐derived podocytes from three patients with Alport syndrome (AS) and proteinuria and one age‐matched non‐proteinuric control. They reported differential expression of genes involved in cell motility, adhesion, survival, and angiogenesis. The authors found AS podocytes to be less motile and to have significantly higher permeability to albumin compared to control podocytes, highlighting that AS podocytes may retain their phenotype even when losing contact with the glomerular basement membrane. The establishment of urine‐derived podocyte cell lines from patients with different genetic forms of AS may represent a valuable and minimally invasive tool to investigate the cellular mechanisms contributing to kidney disease progression in AS and may allow for the establishment of patient‐specific drug screening opportunities. © 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Chimeric antigen receptor T‐cell therapy for marrow and extramedullary relapse of infant acute lymphoblastic leukemia
Authors: Moskop Amy , Pommert Lauren , Thakrar Pooja , Talano Julie , Phelan Rachel 
Published: October 2020

AbstractChimeric antigen receptor (CAR) T‐cells, engineered autologous T‐cells that target antigens found in leukemia, have shown durable remissions in relapsed acute lymphoblastic leukemia (ALL). Infant ALL with KMT2A rearrangements (KMT2Ar) is a rare, aggressive form of leukemia associated with extramedullary disease both at diagnosis and at relapse, and overall outcomes for these patients are dismal. Here we report the successful use of tisagenlecleucel, a CAR T‐cell product approved for relapsed/refractory ALL, in a patient with KMT2Ar infant ALL who was treated for combined marrow and extramedullary (renal) relapse.
Acute effects of aerobic exercise and relaxation training on fatigue in breast cancer survivors: A feasibility trial
Authors: Cohen Jason , Rogers Wendy A. , Petruzzello Steven , Trinh Linda , Mullen Sean P. 
Published: October 2020

AbstractObjectiveThis three‐armed randomized controlled feasibility trial tested the acceptability and acute effects of aerobic exercise and technology‐guided mindfulness training (relative to standalone interventions) on cancer‐related fatigue among breast cancer survivors (BCS).MethodsBCS recruited from Central Illinois completed pre‐ and post‐testing using established measures and were randomized to one of three groups (combined aerobic exercise with guided‐mindfulness relaxation, aerobic exercise only, and relaxation only), conducted in three 90 min sessions over the course of 7 days in a fitness room and research office on a university campus.ResultsWe enrolled 40 BCS (Mage = 57.33 ± 8.75), MBMI = 27.38 ± 5.27, Mfatigue = 4.56 ± 1.81 as measured by the Piper Fatigue Scale. More favorable post‐intervention evaluations were reported by the combined group, compared to aerobic exercise or relaxation only (p < 0.05). Reductions in fatigue favoring the combined group (p = 0.05) showed a modest effect size (Cohen's d = 0.91) compared to aerobic exercise only.ConclusionsThese findings provide preliminary evidence for the feasibility of combining evidence‐based techniques to address fatigue among BCS. The combined approach, incorporating mobile health technology, presents an efficacious and well‐received design. If replicated in longer trials, the approach could provide a promising opportunity to deliver broad‐reaching interventions for improved outcomes in BCS.Preregistered‐ClinicalTrials NCT03702712
Meeting the guidelines: Implementing a distress screening intervention for veterans with cancer
Authors: Azizoddin Desiree R. , Lakin Joshua R. , Hauser Joshua , Rynar Lauren Z. , Weldon Christine , Molokie Robert , Enzinger Andrea C. , Payvar Susan , Martin Joanna L. 
Published: October 2020

AbstractBackgroundGuidelines recommend systematic evaluation of distress screening and referral for cancer patients. Implementation remains a notable gap for cancer centers serving disadvantaged communities. We present the implementation of a distress screening program within a Veterans Affairs hospital oncology clinic, serving a majority African American (AA) male population of low socioeconomic status (SES).MethodsThe Coleman Foundation funded this program supporting a palliative care physician and psychologist to implement screening in a phased approach as follows: (1) Organizing key stakeholders, (2) educating clinical staff, (3) delivering distress screening, (4) generating documentation, and (5) implementing clinical action and referral pathways. We utilized validated measures in the “Patient Screening Questions for Supportive Care” screening tool.ResultsThis program was unsuccessful in screening all veterans with cancer; however, we were able to implement 3 years of longitudinal screening. In distress screens from the initial program period (n = 253), patients were primarily males (95.6%) of older age (m = 70, standard deviation = 9.45), AA (76.4%), with various cancers of advanced disease (69%). Males reported moderate psychosocial distress and elevated financial needs. For males with elevated psychosocial distress (n = 63, PHQ‐4 ≥3), 36% were previously connected with psychosocial services. Following screening, engagement increased as the majority (77%) established psychosocial care.ConclusionsThis screening program had mixed success. Centralized program staff and available supportive care referrals were critical for program implementation. Screening may have increased engagement in social work/mental health services for males of low SES. Screening programs should be tailored to the needs of underserved communities with accessible housing/food subsidies.
Plant awareness disparity: A case for renaming plant blindness
Authors: Parsley Kathryn M. 
Published: October 2020

Societal Impact Statement“Plant blindness” is the cause of several problems that have plagued botany outreach and education for over a hundred years. The general public largely does not notice plants in their environment and therefore do not appreciate how important they are to the biosphere and society. Recently, concerns have been raised that the term “plant blindness” is problematic due to the fact that it is a disability metaphor and equates a disability with a negative trait. In this Brief Report, I place the term “plant blindness” into historical context through a short literature review on the subject and follow this with why the term has been criticized for its ableism. I then propose a more appropriate term to replace plant blindness: plant awareness disparity (PAD) and explain why it both addresses the problems with “plant blindness” while keeping the original reasoning behind the term intact.
A new pest management strategy: transforming a non‐host plant into a dead‐end trap crop for the diamondback moth Plutella xylostella L.
Authors: Zhu Jing‐Yun , Xiang Zhong‐Wen , Zhang Shi‐Ze , Kang Zhi‐Wei , Fan Yong‐Liang , Liu Tong‐Xian 
Published: October 2020

AbstractBACKGROUNDThe use of trap crops can reduce the egg production of female Plutella xylostella in cruciferous vegetables and is an effective method for controlling this pest. To date, most of the trap plants that have been studied are cruciferous plants containing high concentrations of glucosinolates, which are more attractive to P. xylostella female adults. However, the application of these trap plants also has some limitations. Studies have shown that aqueous extracts of cruciferous plants can attract P. xylostella to lay eggs. In this study, we utilized the extract of Chinese kale to treat a non‐host plant, the faba bean, and evaluated the possibility of using it as a dead‐end trap plant for P. xylostella control.RESULTSPlutella xylostella females laid significantly more eggs on faba beans that had been sprayed with the extract of Chinese kale rather than on Chinese kale itself. The first instar larvae of P. xylostella failed to survive on faba beans. Notably, the faba beans with the Chinese kale extract had the strongest attraction effect on P. xylostella females when placed 3 m away from the Chinese kale. Moreover, this attraction effect of faba beans on P. xylostella for oviposition lasted for up to 15 days.CONCLUSIONFaba bean plants sprayed with the aqueous extract of Chinese kale represent a potential dead‐end trap plant for P. xylostella adults and their oviposition while being invariably deadly for their offspring. The present study provides a new proof of concept of using a non‐cruciferous trap plant for P. xylostella management.
Quality loss prediction of mechanical system life considering linear degeneration and random error
Authors: Qian Kangfeng , Liu Xintian , Mao Kui , Wang Xiaolan , Wang Xu 
Published: October 2020

AbstractTo accurately predict quality loss of high reliability and long‐life product in service, a dynamic quality characteristics model is established based on linear degeneration and random error. According to this model, the expectation and variance of dynamic quality characteristics can be figured out. Moreover, assuming that the quality characteristics follow the normal distribution at the initial stage, the expectation of quality loss and the life distribution of dynamic quality characteristics follow three types are derived, such as L‐type (Larger is better), S‐type (Smaller is better), and N‐type (Nominal is better). According to the discount theory of quality loss, the present value model of dynamic quality loss based on the life is derived by combining life and the present value of dynamic quality loss. Then, this model is used to evaluate the quality loss of a GaAs laser and the rationality of the model is analyzed.
PRiSM: A prototype for exhaustive, restriction‐free database searching for mass spectrometry–based identification
Authors: Van Houtven Joris , Boonen Kurt , Baggerman Geert , Askenazi Manor , Laukens Kris , Hooyberghs Jef , Valkenborg Dirk 
Published: October 2020

AbstractRationale: The current methods for identifying peptides in mass spectral product ion data still struggle to do so for the majority of spectra. Based on the experimental setup and other assumptions, such methods restrict the search space to speed up computations, but at the cost of creating blind spots. The proteomics community would greatly benefit from a method that is capable of covering the entire search space without using any restrictions, thus establishing a baseline for identification.Methods: We conceived the “mass pattern paradigm” (MPP) that enables the creation of such an identification method, and we implemented it into a prototype database search engine “PRiSM” (PRotein‐Spectrum Matching). We then assessed its operational characteristics by applying it to publicly available high‐precision mass spectra of low and high identification difficulty. We used those characteristics to gain theoretical insights into trade‐offs between sensitivity and speed when trying to establish a baseline for identification.Results: Of 100 low difficulty spectra, PRiSM and SEQUEST agree on 84 identifications (of which 75 are statistically significant). Of 15 of 100 spectra not identified in a previous study (using SEQUEST), 13 are considered reliable after visual inspection and represent 3 proteins (out of 9 in total) not detected previously.Conclusions: Despite leaving noise intact, the simple PRiSM prototype can make statistically reliable identifications, while controlling the false discovery rate by fitting a null distribution. It also identifies some spectra previously unidentifiable in an “extremely open” SEQUEST search, paving the way to establishing a baseline for identification in proteomics.
Feedback‐based cooperative ramp metering for highway traffic flow control: A model predictive sliding mode control approach
Authors: Tabadkani Aval Seyed Soroush , Eghbal Najmeh 
Published: October 2020

SummaryIn this article, the authors proposed a model predictive based sliding mode control (MPSMC) based ramp metering (RM) strategy for highway traffic control. The strategy includes sliding mode control (SMC) which makes it immune to uncertainties and provides fast responses while the addition of model predictive Control (MPC) will provide optimality. Therefore, the RM strategy will simultaneously present real‐time applicability, robustness, and optimality. To provide optimality, a new quadratic objective function homogeneous to total time spent (TTS) is proposed, and for both the SMC and MPSMC based RM the authors will prove the closed‐loop asymptotic global stability of the strategy in the presence of disturbance and uncertainties with the help of the proposed cost function. This objective function is based on minimizing traffic dynamic deviations from desired values. The proposed RM control strategy was applied to M62 smart highway in England and results are compared with existing control measures in the highway, ALINEA and SMC‐based RM. The simulations show that MPSMC will approach optimal behavior and thus, outperforms ALINEA and SMC regarding queue length and average speed. Moreover, the SMC and MPSMC based RMs are innately robust against disturbances, therefore, both will provide better performance regarding congestion reduction compared with ALINEA. Finally, it will be shown that MPSMC can improve TTS performance by 39% with respect to ALINEA while presenting global asymptotic stability.