bluuebunny/crossref_metadata_2025_split huggingface dataset:
Your Neighbour Is Yourself Reflected in the Mirror of Life
Authors: Sheqi Nitoli , Kaunda Chammah J. 
Published: December 2020

AbstractThis paper engages with the narrative of the Good Samaritan from a Naga perspective in the context of COVID‐19. It demonstrates how Naga Indigenous hospitality, as opposed to contemporary Christianized hospitality in Nagaland, has an affinity with the teaching of Jesus in the narrative. The pertinent question it raises is what the Good Samaritan hospitality would look like if articulated from an Indigenous context during a pandemic. The paper argues that through rereading the story of the Good Samaritan, the Naga churches and society in general have the potential to reclaim and engage Naga’s Indigenous culture of hospitality that supersedes ethnicity in the ongoing pandemic.
Playing God during the Pandemic
Authors: de Gruchy John W. 
Published: December 2020

AbstractAccording to Dietrich Bonhoeffer, in extraordinary situations, when the accepted norms of ethics do not provide clear‐cut answers and even prevent responsible action, human beings must act freely in conformity to the incarnate, crucified, and risen Christ. Being conformed to his incarnation means being involved fully and vicariously in the life and struggles of the world; being conformed to his crucifixion means identifying with the suffering of the victims and being in solidarity with the oppressed; and being conformed to his resurrection means living and acting in hope for the sake of future generations. In seeking to express the love of Christ in the midst of our present‐day pandemic, we are called to act in response to the question “Who is Jesus Christ for us today?” In this way, “Christ’s love moves the world to reconciliation and unity,” not just during a pandemic such as we have experienced, but also at this time in world history when enmity and discord have once again become rampant.
“Everything Is Interrelated”
Authors: Kerber Guillermo 
Published: December 2020

AbstractThe COVID‐19 pandemic has shown that “everything is interrelated,” especially in relation to health, ecology, economy, and climate change, as various authors have stated. The motto is the leitmotif of Pope Francis’ encyclical Laudato si’ and leads to his proposal of an integral ecology. This article deepens the implications of the latter in the encyclical and in other works and shows how the Catholic Synod of Bishops for the Pan‐Amazon Region is an example of the reception and application of integral ecology in a given context. Based on this, the article proposes some conclusions, taking into account the theme of the next assembly of the World Council of Churches in 2022.
“A Mosaic Community Together in the Journey of Faith”
Authors: Kim Afia Sun , Kaunda Chammah J. 
Published: December 2020

AbstractThis article demonstrates how missional churches have emphasized accompaniment as missiological foundation in the COVID‐19 pandemic season. Employing ethnographical method, interviews, and virtual church visits as the primary approach, the paper explores how NextGen Church as the embodiment of Christ’s love has moved communities to solidarity and unity in the middle of global suffering. It concludes that God is on the mission of love and that the pandemic has provided an opportunity for the church to enhance its participation in missio Dei by epitomizing Christ’s love.
Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study
Authors: Walker Alex , Erwig Lars , Foster Katie , Nevin Katherine , Wenzel Joerg , Worm Margitta , Williams Nicola , Ratia Nirav , Hoang Bao , Schneider‐Merck Tanja , Gisbert Sophie , Carnarius Heike , Dickson Marion 
Published: December 2020

AbstractThe immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double‐blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of the selective SYK inhibitor GSK2646264 in active CLE lesions. Two lesions from each participant (n = 11) were each randomized to topical application of 1% (w/w) GSK2646264 or placebo for 28 days; all participants received GSK2646264 and placebo. The primary endpoint was safety and tolerability of GSK2646264, assessed by adverse event incidence and a skin tolerability test. Secondary endpoints included change from baseline in clinical activity and mRNA expression of interferon‐related genes in skin biopsies. Levels of several immune cell markers were evaluated over time. Eight (73%) participants experienced ≥ 1 adverse event (all mild in intensity), and maximal dermal response was similar for GSK2646264 and placebo. The expression of several interferon‐related genes, including CXCL10 and OAS1, showed modest decreases from baseline after 28 days of treatment with GSK2646264 compared with placebo. Similar findings were observed for CD3 + T cell and CD11c + dendritic cell levels; however, overall clinical activity remained unchanged with GSK2646264 vs. placebo. Further studies are warranted to assess SYK inhibitors as potential treatment for CLE.
Anisomycin sensitizes non‐small‐cell lung cancer cells to chemotherapeutic agents and epidermal growth factor receptor inhibitor via suppressing PI3K/Akt/mTOR
Authors: Tan Hongxia , Hu Biao , Xie Fan , Zhu Chuanbing , Cheng Zhenshun 
Published: December 2020

AbstractThe poor outcomes in advanced non‐small‐cell lung cancer (NSCLC) necessitate new treatments. Recent studies emphasize anisomycin as a promising anti‐cancer drug candidate. In this work, we systematically investigated the efficacy of anisomycin alone and its combination with the standard‐of‐care drugs in NSCLC. We showed that anisomycin inhibited growth, migration, and survival in NSCLC cells regardless of genetic mutation status, and to a greater extent than in normal lung epithelial cells. Isobologram analysis showed that the combination of anisomycin with cisplatin, paclitaxel, or gefitinib was synergistic in NSCLC but not normal lung cells. We further demonstrated that anisomycin inhibited NSCLC growth in mice. The combination of anisomycin with cisplatin was more effective than cisplatin alone and completely arrested NSCLC growth throughout the whole duration of treatment. JNK and p38 MAPK were not required for anisomycin’s action. In contrast, anisomycin inhibits PI3K/Akt/mTOR pathway. Overexpression of constitutively active Akt reversed the pro‐apoptotic effect of anisomycin. Our work demonstrates the selective anti‐NSCLC activity of anisomycin via suppressing PI3K/Akt/mTOR. Our findings provide preclinical evidence to initialize the clinical trial of using anisomycin to sensitize NSCLC to current therapy.
Videoconferencing and the development of intercultural competence: Insights from students' self‐reflections
Authors: Tecedor Marta , Vasseur Raychel 
Published: December 2020

AbstractThis manuscript contributes to the existing body of literature on intercultural communicative competence (ICC) in the context of computer‐mediated communication by examining how fourth‐semester learners of Spanish (n = 18) display and develop ICC over the course of a semester. Novel to this study are: (1) the use of service‐provider virtual exchanges to carry out the videoconferencing conversations between second language (L2) learners and native speakers (NSs) and (2) the use of both Byram's ICC objectives and Bennett's ethnocentric and ethnorelative perspectives to analyze students' written reflection papers following videoconferencing conversations with NSs. The use of these two frameworks allowed us to map how students conceptualize and experience cultural difference during videoconferencing exchanges and show how their interpretations evolve, shaping their attitudes toward and their beliefs about the target cultures and its speakers. Our findings indicate that instead of relying solely on Byram's ICC framework, as is traditional, combining aspects of Bennett's Developmental Model of Intercultural Sensitivity with Byram's assessment guidelines is a fruitful and efficient way for foreign language instructors to accurately identify the developmental stage of their students and design appropriate instructional activities.
High temperatures enhance the microbial genetic potential to recycle C and N from necromass in high‐mountain soils
Authors: Donhauser Jonathan , Qi Weihong , Bergk‐Pinto Benoît , Frey Beat 
Published: December 2020

AbstractClimate change is strongly affecting high‐mountain soils and warming in particular is associated with pronounced changes in microbe‐mediated C and N cycling, affecting plant‐soil interactions and greenhouse gas balances and therefore feedbacks to global warming. We used shotgun metagenomics to assess changes in microbial community structures, as well as changes in microbial C‐ and N‐cycling potential and stress response genes and we linked these data with changes in soil C and N pools and temperature‐dependent measurements of bacterial growth rates. We did so by incubating high‐elevation soil from the Swiss Alps at 4°C, 15°C, 25°C, or 35°C for 1 month. We found no shift with increasing temperature in the C‐substrate‐degrader community towards taxa more capable of degrading recalcitrant organic matter. Conversely, at 35°C, we found an increase in genes associated with the degradation and modification of microbial cell walls, together with high bacterial growth rates. Together, these findings suggest that the rapidly growing high‐temperature community is fueled by necromass from heat‐sensitive taxa. This interpretation was further supported by a shift in the microbial N‐cycling potential towards N mineralization and assimilation under higher temperatures, along with reduced potential for conversions among inorganic N forms. Microbial stress‐response genes reacted inconsistently to increasing temperature, suggesting that the high‐temperature community was not severely stressed by these conditions. Rather, soil microbes were able to acclimate by changing the thermal properties of membranes and cell walls as indicated by an increase in genes involved in membrane and cell wall modifications as well as a shift in the optimum temperature for bacterial growth towards the treatment temperature. Overall, our results suggest that high temperatures, as they may occur with heat waves under global warming, promote a highly active microbial community capable of rapid mineralization of microbial necromass, which may transiently amplify warming effects.
The patterns and driving forces of uneven regional growth in ASEAN countries: A tale of two Thailands' path toward regional coordinated development
Authors: Lang Wei , Pan Muzhe , Wu Jiemin , Chen Tingting , Li Xun 
Published: December 2020

AbstractUneven development has long been a critical issue in geography and urban studies, leading to economically inefficient urbanization, environmentally unbalanced regions, and socially unequal livelihoods. As one result, primate cities and urban primacy form within a hierarchical urban system, to which urban and regional planning must positively respond. It is worth noting that Thailand has experienced a number of important urbanization issues related to developing countries, such as semicolonialism and internal colonialism. This study aims to investigate regional uneven development based on primacy theory and the rank‐size rule, which are common in most Asian and developing countries. We examined the urbanization processes in Thailand, from 2000 to 2015, by looking at factors of population, GDP, land use, transportation networks, and nighttime light, which provide very recent regional development patterns. The second set of analyses explained the degree of primacy among different provinces and their ranking hierarchies. By presenting the persistent disparities of contemporary urbanization in Thailand and exploring its driving forces, this study offers insights into planning and policy and underscores the importance of regional coordinated development for achieving sustainable urbanization in Southeast Asian countries.
Low rate of subclinical venous thrombosis in patients with haemophilia undergoing major orthopaedic surgery in the absence of pharmacological thromboprophylaxis
Authors: Verstraete Géraldine , Lambert Catherine , Hammer Frank , Hermans Cedric 
Published: December 2020

AbstractBackgroundDeep venous thrombosis (DVT) is a common postoperative complication in patients undergoing major orthopaedic surgery of the lower limbs, such as total hip or knee replacement (THR, TKR). Routine pharmacological thromboprophylaxis with low‐molecular‐weight heparin (LMWH) or a direct oral anticoagulant agent is strongly recommended in this setting. THR and TKR as well as ankle arthrodesis are frequently performed in people with haemophilia (PWH) and chronic haemophilic arthropathy. Pharmacological thromboprophylaxis in this population remains controversial.MethodsWe report the results of a single‐centre prospective study initiated in 2002 evaluating by systematic Doppler ultrasound the incidence of subclinical DVT in consecutive PWH referred for major orthopaedic surgery and not receiving pharmacological thromboprophylaxis.ResultsWe included 46 different PWH (39 Haemophilia A, 7 Haemophilia B, 27 severe, 15 moderate and 4 mild forms) undergoing 67 orthopaedic procedures. Most (89.5%) were performed with continuous infusion of clotting factor concentrates. Rehabilitation was usually started on day 1 post‐op. No clinical DVT or pulmonary embolism was suspected. In total, there were 5 cases (3 severe, 1 moderate HA and 1 moderate HB) of subclinical DVT which were all distal. Two patients were treated with a short course (10‐14 days) of LMWH. The overall incidence of DVT was 7.5%.ConclusionsThese data provide imaging‐based evidence that the risk of DVT following major orthopaedic surgery among PWH is low. Identified DVTs were distal and resolved spontaneously in most cases. Systematic pharmacological thromboprophylaxis in this specific population is probably for most patients not required.
Effects of petrolatum, a petrolatum depositing body wash and a regular body wash on biomarkers and biophysical properties of the stratum corneum
Authors: Wei Karl , Stella Ching , Wehmeyer Kenneth , Christman Jeremy , Altemeier Amy , Spruell Russell , Wimalasena Rohan , Fadayel Gina , Wickett R. Randall 
Published: December 2020

AbstractBackgroundAn important trend in the personal care industry involves the development of body wash products that not only clean the skin without damage but deposit conditioning ingredients to improve skin barrier function.ObjectiveThe objective of this study was to develop skin biomarker measures to quantify the treatment effects of body wash products.MethodsWe employed analysis of structural proteins (keratin 1,10,11 and involucrin), a natural moisturizing factor (pyrrolidone carboxylic acid) and an inflammatory mediator (IL‐1ra/IL‐1α) from adhesive discs with dry skin grading, TEWL and capacitance measurements to compare the effects of direct application of petrolatum, a high petrolatum depositing body wash, and a regular body wash on dry leg skin in a standard leg‐wash treatment protocol.ResultsHigh depositing body wash and petrolatum had positive effects on stratum corneum barrier function as judged by biomarker analysis, biophysical measurements and skin grading compared to the regular body wash product.ConclusionsThe results clearly indicate that a combination of biomarker and biophysical property measurements is effective for determining the skin benefits of moisturizing body wash products.
Risks of vaptans in hypernatremia and serum sodium overcorrection: A systematic review and meta‐analysis of randomised controlled trials
Authors: Zhou Ya , Yang Wenru , Liu Guotao , Gao Weiyi 
Published: December 2020

AbstractObjectiveSerum sodium overcorrection and hypernatremia are significant health risks. We conducted a systematic review and meta‐analysis to evaluate the risks of vaptans in hypernatremia and serum sodium overcorrection.MethodsWe searched PubMed, Embase, and CENTRAL for randomised controlled trials. We included studies comparing vaptans and placebo with data on hypernatremia and serum sodium overcorrection. The study quality was assessed using the Cochrane Collaboration's risk‐of‐bias assessment tool. Fixed‐effect model meta‐analysis was used to pool the data. Different analyses were performed to ensure the accuracy of the results.ResultsTwenty‐eight studies were included in the meta‐analysis of hypernatremia incidence. Treatment with vaptans resulted in a higher risk of hypernatremia than placebo (3.8% vs 1.0%, odds ratio [OR] 2.69; 95% confidence interval [CI] 1.97‐3.68). The subgroup with baseline hyponatremia had a lower risk of hypernatremia incidence; however, the use of loop diuretics increased the risk. Fourteen studies were included in the analysis of the incidence of serum sodium overcorrection. A higher risk of serum sodium overcorrection was found in using vaptans vs placebo (4.4% vs 1.4%; OR 2.26; 95% CI 1.32‐3.86).ConclusionVaptans showed higher risks in the incidence of hypernatremia and serum sodium overcorrection than placebo. In addition, combination with loop diuretics increased the risk of hypernatremia. The risk of serum sodium overcorrection should be concerned in patients with hyponatremia and normal serum sodium equally. Using a low dose of vaptans can reduce both risks.
Dexamethasone vs COVID‐19: An experimental study in line with the preliminary findings of a large trial
Authors: Hosseinzadeh Mohammad Hossein , Shamshirian Amir , Ebrahimzadeh Mohammad Ali 
Published: December 2020

AbstractBackgroundThe preliminary report of the RECOVERY large randomised controlled trial indicated a promising survival effect for dexamethasone therapy of coronavirus disease 2019 (COVID‐19). This study aimed to investigate the anti‐hypoxic activities of dexamethasone to understand a possible mechanism of its action in hypoxia‐induced lethality through experimental models of hypoxia.MethodsIn this investigation, 84 Male BALB/c mice were randomly divided into groups of seven (12 groups). Treatment groups received 10 days of dexamethasone intraperitoneal injection at both human dose (~0.1 mg/kg) and the animal does (~1 mg/kg). Control negative and positive groups were treated with 10 ml/kg of normal saline and 30 mg/kg of propranolol, respectively. Three experimental models of hypoxia, asphyctic, circulatory, and hemic were applied in this study.ResultsThe findings showed that dexamethasone significantly prolonged the latency for death in the asphyctic model concerning the control group in both humans (P < .0001) and animal dose (P < .0001). The results were also highly significant for both doses in the hemic model (P < .001). In the circulatory model, although a small increase was observed in death prolongation, results were not statistically significant for both doses in this model (P > .05).ConclusionsThis experimental in vivo investigation demonstrated an excellent protective effect for 10 days of dexamethasone treatment against hypoxia, especially in asphyctic and hemic models. In addition to promising dexamethasone outcomes, using propranolol as the positive control illustrated a very substantial anti‐hypoxic effect even much better than dexamethasone in all models. It seems that propranolol would be a safe, potential, and prudent choice to invest in treating COVID‐19 patients.
Time preference and international trade
Authors: Iwasa Kazumichi , Nishimura Kazuo 
Published: December 2020

AbstractWe first consider a closed model, where households' time discount depends on externality in consumption. We can prove that there is a unique steady state, which is a saddle point. Then we extend the model to a two‐country world, and derive the condition on the effects of consumption externality under which there is a unique free trade steady state with saddle‐point stability.
The Challenge of Autism for Relational Approaches to Theological Anthropology
Authors: Leidenhag Joanna 
Published: December 2020

AbstractIn this paper, I argue that autism places an important restraint upon the use of relationality in theological anthropology. This argument proceeds by outlining how the appropriation of dialectic personalism, which initiated ‘the relational turn’ in twentieth century theological anthropology, has struggled to escape the capacity or property‐based focus on individual subjects. As such, this relational account remains discriminatory against those who do not or cannot enact a particular kind of relationality, as some models of autism suggest. Moreover, attention to interpersonal relationships as a key human capacity within twentieth century theological anthropology closely parallels and may even have informed the development of autism within psychology as, in part, a social impairment. The devastating collision of these two intellectual trajectories is made apparent in explicit references by contemporary theologians to autism as a condition that prevents some humans from bearing the image of God, developing fully into persons, or receiving God’s grace by the indwelling of the Holy Spirit.
Diagnostic performance of prostate cancer antigen 3 and the Prostate Health Index in detecting overall and clinically significant prostate cancer in men at first biopsy: A meta‐analysis
Authors: Jia Wei , Wu Bo , Shao Yuan , Cao Xiaoming , Wang Dongwen 
Published: December 2020

ObjectiveTo evaluate the diagnostic value of prostate cancer antigen 3 and the Prostate Health Index for the detection of overall and clinically significant prostate cancer at initial biopsy.MethodsA search was conducted in the online databases PubMed, Embase and the Cochrane database, and relevant articles published up to 23 February 2020 were extracted.ResultsTwenty studies including 10 376 patients were included in the meta‐analysis. The pooled sensitivity and specificity were 0.55 (95% confidence interval 0.53–0.57) and 0.74 (95% confidence interval 0.72–0.75) for prostate cancer antigen 3 and 0.88 (95% confidence interval 0.86–0.90) and 0.36 (95% confidence interval 0.34–0.38) for the Prostate Health Index. The area under the curve was 0.72 for prostate cancer antigen 3 and 0.76 for the Prostate Health Index. The combination of prostate cancer antigen 3 and the Prostate Health Index had a higher area under the curve (0.79) and diagnostic odds ratio (5.83) than the use of Prostate Health Index (area under the curve 0.75, diagnostic odds ratio 4.69) or prostate cancer antigen 3 (area under the curve 0.77, diagnostic odds ratio 4.84) alone. For clinically significant prostate cancer detection, the pooled sensitivity and specificity were 0.80 (95% confidence interval 0.76–0.84) and 0.53 (95% confidence interval 0.50–0.55), respectively, for prostate cancer antigen 3, and 0.77 (95% confidence interval 0.71–0.82) and 0.64 (95% confidence interval 0.61–0.67), respectively, for the Prostate Health Index. The area under the curve was 0.71 for prostate cancer antigen 3 and 0.77 for the Prostate Health Index.ConclusionBoth the Prostate Health Index and prostate cancer antigen 3 showed acceptable and similar results for the detection of overall and clinically significant prostate cancer at first biopsy. A combination of these two diagnostic tests may be more helpful than the use of either test alone in prostate cancer management.