bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Ontology Based Competence Management Model for Non-Formal Education Services
Authors: Zandbergs Uldis , Grundspeņķis Jānis , Judrups Jānis , Briķe Signe 
Published: February 2020

Abstract
Competence management is a discipline that recently has regained popularity due to the growing demand for constantly higher competences of employees as well as graduates. One of the main implementation challenges of competence management is that, as a rule, it is based on experts’ implicit knowledge. This is the reason why the transformation of implicit knowledge into explicit knowledge practically is unmanageable and, as a consequence, limits the ability to transfer the already existing knowledge from one organisation to another.
The paper proposes an ontology-based competence model that allows the reuse of existing competence frameworks in the field of non-formal education where different competence frameworks need to be used together for the purpose of identification, assessment and development of customers’ competences without forcing the organisations to change their routine competence management processes. The proposed competence model is used as a basis for development of competence management model on which IT tools that support a competence management processes may be built up. Several existing frameworks have been analysed and the terminology used in them has been combined in a single model. The usage of the proposed model is discussed and the possible IT tools to support the competence management process are identified in the paper.
The Eco-Modification of Textiles Using Enzymatic Pretreatment and New Organic UV Absorbers
Authors: Olczyk Joanna , Sójka-Ledakowicz Jadwiga , Kudzin Marcin , Antecka Anna 
Published: February 2020

Abstract
Textile fabrics were subjected to bio-pretreatment using high-activity laccase from Cerrena unicolor for comparison to standard alkaline scouring and organic absorber of ultraviolet (UV) radiation based on 1,3,5-triazine derivatives. The basic aim of the study was the development of textiles made of natural cellulose fibers (mainly flax or its blends with cotton) to provide barrier properties against UV radiation. Controlled application of enzymatic pretreatment of woven fabrics made of natural cellulose fibers allows for an efficient removal of impurities from these fibers, resulting in the improvement of sorptive properties and good penetration of dyeing agents, UV organic absorbers and other chemical modifiers, into the textile structure. In this way, products with UV-protection properties (ultraviolet protection factor >40) are obtained. These innovative barrier materials can be used for outdoor textiles that protect professional people from harmful effects of UV radiation.
Short communication: Chlorpromazine causes a time-dependent decrease of lipids in Saccharomyces cerevisiae
Authors: Muhieddine Dina , Moughnié Mohamad , Abdel-Razzak Ziad 
Published: February 2020

Abstract
Chlorpromazine (CPZ) is still a commonly prescribed antipsychotic which causes poorly understood idiosyncratic toxicity such as cholestasis, phospholipidosis and steatosis. CPZ has diverse cellular targets and exerts various toxicity mechanisms whose exploration is necessary to understand CPZ side effects. We report here that CPZ causes a decrease of total lipid content in Saccharomyces cerevisiae at the same dose range as that used on mammalian cells. The observed lipid decrease was obvious after 4 and 9 hours of treatment, and disappeared after 24 hours due to cells adaptation to the chemical stress. The inhibitory effect of CPZ was antagonized by the antioxidant N-acetyl L-cysteine and is likely caused by the parent compound. The obtained results demonstrate that yeast model is valid to investigate the involved CPZ toxicity mechanisms, particularly in terms of lipids alteration. This would contribute to understand CPZ side effects in simple model and reduce experimentation on animals.
Aluminium toxicosis: a review of toxic actions and effects
Authors: Igbokwe Ikechukwu Onyebuchi , Igwenagu Ephraim , Igbokwe Nanacha Afifi 
Published: February 2020

Abstract
Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.
World of earthworms with pesticides and insecticides
Authors: Miglani Rashi , Bisht Satpal Singh 
Published: February 2020

Abstract
Earthworms are important organisms in soil communities and are known for sustaining the life of the soil. They are used as a model organism in environmental risk assessment of chemicals and soil toxicology. Soil provides physical and nutritive support to agriculture system by regulating biogeochemical cycles, nutrient cycle, waste degradation, organic matter degradation etc. The biggest threat to soil health are pesticides and synthetic chemicals including fertilizers. Earthworms are most severely hit by these xenobiotic compounds leading to a sizeable reduction of their population and adversely affecting soil fertility. Earthworms are incredible soil organisms playing a crucial role in maintaining soil health. Pesticides used in crop management are known to be most over-purchased and irrationally used soil toxicants, simultaneously, used insecticides contribute to a quantum of damage to earthworms and other non-target organisms. LC50 and LD50 studies revealed that earthworms are highly susceptible to insecticides causing immobility, rigidity and also show a significant effect on biomass reduction, growth and reproduction by disrupting various physiological activities leading to loss of earthworm population and soil biodiversity.
Probiotics against alleviation of lead toxicity: recent advances
Authors: Bhattacharya Sanjib 
Published: February 2020

Abstract
Lead is a toxic heavy metal and there is no specific, safe and efficacious therapeutic management of lead toxicity. Scientific literature reported that some probiotic microorganisms alleviated experimentally induced lead toxicity. The present review attempts to collate the experimental studies on probiotics with ameliorative effects. Literature survey revealed that four (4) types of probiotic microorganisms exhibited significant protection from lead toxicity in experimental pre-clinical studies. No clinical study with significant outcome was found in the literature. From the outcomes of the preclinical studies it appears that probiotics are prospective for alleviation and treatment of lead toxicity.
General toxicity assessment of the novel aldose reductase inhibitor cemtirestat
Authors: Prnová Marta Šoltésová , Račková Lucia , Kováčiková Lucia , Balleková Jana , Viskupičová Jana , Micháliková Silvia , Taşkoparan Betul , Elmazoğlu Zübeyir , Rižner Tea Lanišnik , Karasu Cimen , Banerjee Sreeparna , Štefek Milan 
Published: February 2020

Abstract
Cemtirestat, 3-mercapto-5H-[1,2,4]-triazino[5,6-b]indole-5-acetic acid was recently designed and patented as a highly selective and efficient aldose reductase inhibitor endowed with antioxidant activity. The aim of the present study was to assess the general toxicity of cemtirestat using in silico predictions, in vitro and in vivo assays. ProTox-II toxicity prediction software gave 17 “Inactive” outputs, a mild hepatotoxicity score (0.52 probability) along with a predicted LD50 of 1000 mg/kg. Five different cell lines were used including the immortalized mouse microglia BV-2, the primary human fibroblasts VH10, the insulinoma pancreatic β-cells INS-1E, the human colon cancer cells HCT116 and the human immortalized epithelial endometrial cell lines HIEEC. In contrast to the clinically used epalrestat, cemtirestat showed remarkably low cytotoxicity in several different cell culture viability tests such as MTT proliferation assay, neutral red uptake, BrdU incorporation, WST-1 proliferation assay and propidium iodide staining followed by flow cytometry. In a yeast spotting assay, the presence of cemtirestat in incubation of Saccaromyces cerevisiae at concentrations as high as 1000 µM did not affect cell growth rate significantly. In the 120-day repeated oral toxicity study in male Wistar rats with daily cemtirestat dose of 6.4 mg/kg, no significant behavioral alterations or toxicological manifestations were observed in clinical and pathological examinations or in hematological parameters. In summary, these results suggest that cemtirestat is a safe drug that can proceed beyond preclinical studies.
Evaluation of acute toxicity of vinasse by means of Daphnia magna and Aliivibrio fischeri: a comparative study
Authors: Velásquez-Riaño Möritz , Meneses-Sánchez Juan Sebastían , Arias Carel Elizabeth Carvajal 
Published: February 2020

Abstract
In the bioethanol industry, per liter of the produced alcohol 9 to 14 liters of vinasse are obtained as a byproduct. If the vinasse is directly shed into bodies of water without an adequate treatment, it may have negative effects on the existing biota and human health due to its high turbidity and color, low pH and high content of organic material. The purpose of this study was to assess the acute toxicity of vinasse by means of a rapid test with Aliivibrio fischeri and compare it with a standard immobilization assay with Daphnia magna. The standard assay of D. magna by means of its EC50 of 4.7% showed that organism was more sensitive to the contaminant, in comparison with the 69.6% obtained with the A. fischeri which suggests that it should be continuesly used as one of the organisms of first choice for the evaluation of the acute toxicity of this effluent.
Influence of estrous stages on electrocardiography, clinical pathology and ovarian weight of experimental beagle dogs: a retrospective analysis
Authors: Shah Chitrang , Bhatt Laxit , Ravichandra B.V. , Kothule Viren , Kadam Shekhar , Nataraju G.J. , Patel Jitendra , Ranvir Ramachandra , Bhatnagar Upendra , Sundar S. Rajesh , Jain Mukul 
Published: February 2020

Abstract
Estrous cycle is a repetitive phenomenon occurring during the reproductive life of a female dog. The duration of the canine estrous cycle is considerably longer than one in the most of the other animals and is broadly grouped into follicular phase (proestrus and estrus), luteal phase (diestrus) and non-seasonal anestrus. Dogs in the same stage of cycle can be inadvertently assigned to same group during routine safety and metabolic studies leading to possible erroneous interpretation of test-item related effects. This retrospective analysis was conducted by analyzing data of 86 female beagle dogs from control/placebo treated groups to correlate any possible effect of estrous stages with electrocardiography, clinical pathology and ovarian weight. Different estrous cycle stages of beagles were confirmed histologically by evaluating ovary, uterus, vagina and mammary glands. The incidence of beagles in diestrus was the highest, followed by anestrus, proestrus and estrus. No significant effect was noticed on heart rate, P–A, P–D, RR, QRS and QT intervals across different stages of estrous cycle. However, significantly higher PQ (PR) interval in dogs in proestrus stage was observed compared to dogs in anestrus and estrus. Marginally higher WBCs, neutrophils, lymphocytes, RBCs, hemoglobin, AST and lower hematocrit, lipid profile (total cholesterol, HDL, LDL, triglycerides), ALP level was evident in estrous period. Relative ovary weight was significantly higher in dogs in diestrus stage. Considering these results, one may need to exercise caution while interpreting experimental data from female beagle dogs.
Alternative Leprosy Treatment Using Rifampicin Ofloxacin Minocycline (ROM) Regimen – Two Case Reports
Authors: Widjaja Yohanes , Djawad Khairuddin , Amin Saffruddin , Djamaluddin Widyawati , Kadir Dirmawati , Muchtar Sri V. 
Published: February 2020

Abstract

Introduction. Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy, paucibacillary (PB) and multibacillary (MB). The standard treatment for leprosy employs the use of WHO MDT (Multi Drug Treatment) regimen, despite its multiple downsides such as clofazimine-induced pigmentation, dapsone-induced haematological adverse effects, poor compliance due to long therapy duration, drug resistance, and relapse. Multiple studies and case reports using ROM regimen have reported satisfactory results. Nevertheless, there are still insufficient data to elucidate the optimum dosage and duration of ROM regimen as an alternative treatment for leprosy. Previous experience from our institution revealed that ROM regimen given three times weekly resulted in a satisfactory outcome.

Case Reports. We report two cases of leprosy treated with ROM regimen from our institution. The first case was PB leprosy in a 64-year-old male who presented with a single scaly plaque with erythematous edge on the right popliteal fossa. Sensibility examination showed hypoesthesia with no peripheral nerve enlargement. Histopathological examination confirmed Borderline Tuberculoid leprosy. ROM regimen was started three times weekly for 6 weeks and the patient showed significant clinical improvement at the end of the treatment with no reaction or relapse until after 6 months after treatment. The second case was MB leprosy in a 24-year-old male patient with clawed hand on the 3rd-5th phalanges of the right hand and a hypoesthetic erythematous plaque on the forehead. Histopathology examination confirmed Borderline leprosy. The patients received ROM therapy 3 times a week with significant clinical improvement after 12 weeks.

Conclusion. ROM regimen given three times weekly for 6 weeks in PB leprosy and 12 weeks in MB leprosy resulted in a significant clinical improvement. Thus, ROM regimen could be a more effective, safer, faster alternative treatment for leprosy.
Acne Necrotica (Varioliformis) – Case Report
Authors: Nikolić Marija , Perić Jelena , Škiljević Dušan 
Published: February 2020

Abstract
Acne necrotica is a rare disease, characterized by repeated cropping of inflammatory papules and papulo-pustules, which rapidly necrotize and leave varying degrees of varioliform scars that may lead to cicatricial alopecia when terminal hair-bearing sites are involved. In early lesions, pathology shows necrotizing lymphocytic folliculitis. We report a 63-year-old male patient with chronic, relapsing, umbilicated and centrally necrotic erythematous papules and papulo-pustules involving the frontal hairline area, face, and neck. Histopathology showed epidermal spongiosis and lymphocytic exocytosis, extensive necrosis and destruction of the follicular epithelium, a dense diffuse lymphohistiocytic infiltrate and necrosis of the perifolicular dermis. The diagnosis of acne necrotica was made based on the correlation of clinical and histopathological findings. A complete clinical remission was achieved with topical erythromycin and benzoyl peroxide.
Bird mortality on medium-voltage power lines in the Czech Republic
Authors: Škorpíková Vlasta , Hlaváč Václav , Křápek Milan 
Published: February 2020

Abstract
In 2015–2016, 6,429 km medium-voltage power lines with 76,430 pylons were checked for bird mortality in the Czech Republic. 1,326 bird victims of power lines were found, 156 of which died after collisions, and 1,170 birds were electrocuted. They belonged to 60 species from 12 orders, and birds of prey made up almost half of all victims. Steel pylons bearing several cross-arms including upper and crosswise jumpers were identified as most dangerous from the electrocution point of view. On the other hand, pylons in straight lines with Pařát cross-arms (triangular arrangement of conductors without any horizontal bar) were among the least dangerous, and when they had a simple perch fitted below the cross-arm, no mortality was recorded. But these pylons are new in practice and despite becoming widely used recently, they form less than one tenth of all pylons in the Czech Republic. On other pylons various types of mitigation measures have been installed. Commonly used plastic covers and plastic strips have proved to be especially effective, but only in cases when they are undamaged and correctly installed.
Changes in nesting habitat of the saker falcon (Falco cherrug) influenced its diet composition and potentially threatened its population in Slovakia in the years 1976–2016
Authors: Chavko Jozef , Obuch Ján , Lipták Ján , Slobodník Roman , Baláž Michal 
Published: February 2020

Abstract
In the period between the years 1976 to 2016 we monitored the nesting site distribution of two populations of saker falcon (Falco cherrug) concentrated in the highlands and adjacent lowlands of western and eastern Slovakia. In western Slovakia we recorded nesting by 56 pairs and 514 nestings, and in eastern Slovakia we observed nesting by 32 pairs and 245 nestings. There were similar nesting success rates in both regions, with pairs producing on average 3.2 young in every successful nest. During the monitored period as a whole a total of 1,788 young saker falcons were raised. At the same time all the pairs gradually resettled in the lowlands, and in the new environment the nesting success rate significantly improved (81.1% compared with 57.1 % in the highlands). This change of nesting biotopes was caused by the impacts of intensive exploitation and environmentally inappropriate forest management, with the accompanying excessive disturbance of nesting birds, but at the same time the disappearance of ground squirrel (Spermophilus citellus) colonies led to a change in the food spectrum for the observed saker falcon pairs. We evaluated the falcons’ feeding habits in western Slovakia between the years 1977 and 2016 (49 pairs; 1–17 pairs/year) and in eastern Slovakia between 2009 and 2016 (12 pairs; 1–3 pairs/year). Altogether 17,669 prey items were identified. From 1976 onwards mammals (Mammalia, 19.8%, 24 species) became gradually less represented as a component in the falcons’ diet compared with birds (Aves, 79.9%, 58 species). In areas of western Slovakia we found stable and predominant proportions of domestic pigeons (Columba livia f. domestica) ranging from 52% to 62%. The proportion of pigeons was distinctly lower in eastern Slovakia (31.5%), compensated for by larger shares of common vole (Microtus arvalis), common starling (Sturnus vulgaris), Eurasian magpie (Pica pica) and hooded crow (Corvus cornix). The common starling (9.5%) was a significant prey species in the lowlands of western and eastern Slovakia alike. Mammals were mostly represented by common voles (9.8%), European hamsters (Cricetus cricetus, 5.3%), ground squirrels (2.1%) and hares (Lepus europaeus, 1.6%). Changes over time in the composition of falcons’ prey were also evaluated over five periods in western Slovakia.
Viscardi, Nilia y Tenenbaum, Gabriel (Coords.) (2016). Juventudes y violencias en América Latina. Sobre los dispositivos de coacción en el siglo XXI
Authors: Álvarez Hernández Emmanuel 
Published: February 2020

Esta obra es un producto sociológico conformado en la Universidad de la República de Uruguay bajo la coordinación de Viscardi y Tenenbau con el objeto de deconstruir la economía simbólica de la violencia institucional que atraviesa las entidades educativas. En ella se visualiza a los jóvenes como actores dominados y se objetiva la violencia institucional, la cual trasciende la criminalización de la juventud, considerando gran diversidad de variables vinculadas al género, a la prisión o reclusión, al sector educativo, la situación laboral y los vacíos del Estado, donde actores no institucionales ejercen la dominación y se imponen mediante la coacción. 11. Viscardi, Nilia and Tenenbaum, Gabriel (Coords.) (2016). Youth and violence in Latin America. Coercion devices in the 21st centurySummaryThis work is a sociological product created at the University of the Republic of Uruguay under the coordination of Viscardi and Tenenbau in order to deconstruct the symbolic economy of institutional violence that educational entities go through. In it, young people are seen as dominated actors and institutional violence is objectified, which transcends the criminalization of youth, considering a great diversity of variables related to gender, prison or seclusion, the education sector, the employment situation and State gaps, where non-institutional actors exert domination and impose themselves through coercion. Viscardi, Nilia et Tenenbaum, Gabriel (Coords.) (2016). Jeunesses et violences en Amérique Latine. Sur les dispositifs de contrainte au XXIe. siècle.RésuméCe travail est un produit sociologique formé dans l’Universidad de la República d’Uruguay sous la coordination de Viscardi et Tenenbau avec l’objet de déconstruire l’économie symbolique de la violence institutionnelle qui traverse les entités d’éducation. Dans son intérieur on visualise les jeunes comme des acteurs dominés et on objective la violence institutionnelle qui dépasse la criminalisation de la jeunesse tout en considérant une grande diversité de variables liées au genre, à la prison ou la réclusion, au secteur éducatif, la situation de travail et les vides de l’État où les acteurs institutionnels exercent la domination et ils s’imposent à travers la contrainte.