bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastrosplenocolic fistula secondary to non-Hodgkin B-cell lymphoma
Authors: Yokoyama Yujiro , Kashyap Sarang , Ewing Edward , Bloch Robert 
Published: December 2019

Abstract
Gastrocolic fistula (GSF) is a rare entity that arises mainly from splenic or gastric lymphoma. Gastric and splenic lymphomas can also fistulate with other organs, including the pleura and the colon, but there has been no reported case to best of our knowledge of a fistula involving three different organs. We hereby present the case of a female patient with gastrosplenocolic fistula secondary to non-Hodgkin B-cell lymphoma. We performed an en bloc partial gastrectomy with splenectomy and partial left colon resection with colostomy. GSF can be treated with chemotherapy. However, when the definite diagnosis is unclear or GSF is causing serious complications such as bleeding or active infection, we believe surgical excision is the treatment of choice.
Stylistic palimpsests: Computational stylistic perspectives on precursory authorship in Aphra Behn’s drama
Authors: Evans Mel , Hogarth Alan 
Published: December 2019

Abstract
Computational stylistics has developed various methods for investigating and attributing authorship of collaborative literary texts. This article investigates ‘precursory authorship’ (Love, 2002): that is, the authorial traces of a source text that inform—to a greater or lesser degree—a subsequent literary output, in order to establish its relevance for our approach to and understanding of the linguistic properties of literary style. Precursory authorship and derivative adaptations are common features of early modern English drama, and the study focusses on two case studies relating to the plays of Restoration playwright, Aphra Behn (c. 1640–89). Using a combination of quantitative methods (Rolling Delta (RD), principal components analysis (PCA), Delta, and Hierarchical Cluster Analysis), the investigation highlights the presence of precursory authorial style in Behn’s The Rover and an anonymous work associated with Behn, The Counterfeit Bridegroom. The results suggest that precursory authorial style is identifiable in both cases, not only through a similarity with the source text but, to a lesser degree, other texts by the precursory author as well. The anonymous play yields complex and non-confirmatory evidence for Behn’s authorship. Methodologically, RD is most sensitive to precursory collaboration. Collectively, the findings highlight the importance of stylistic factors when describing and interpreting literary linguistic quantitative data: precursory authorial style is another facet that intersects with properties such as time period and genre. The article urges a more critical and theoretically informed view of authorially aligned linguistic style.
Cardiovascular risk of nonsteroidal anti-inflammatory drugs in dialysis patients: a nationwide population-based study
Authors: Jo Hyung Ah , Kim Dong Ki , Park Seokwoo , Kim Yaerim , Han Seung Seok , Yang Bo Ram , Choi So-Hyun , Kim Mi-Sook , Lee Joongyub , Lee Hajeong , Lee Jung Pyo , Lim Chun Soo , Kim Yon Su , Joo Kwon Wook 
Published: December 2019

Abstract

Background
Given the cardiovascular risk of nonsteroidal anti-inflammatory drugs (NSAIDs), it is essential to identify the relationship between NSAIDs and cardiovascular outcomes in dialysis patients who have elevated cardiovascular risk.

Methods
A case-crossover study was conducted to assess the association of NSAIDs with major adverse cardiac and cerebrovascular events (MACCEs) and mortality using the Korean Health Insurance dataset. The case period was defined as 1–30 days prior to the event date and the control periods were defined as 61–90 days and 91–120 days prior to the event date.

Results
There were 3433 and 8524 incident dialysis patients who experienced MACCEs and mortality, respectively, after exposure to NSAIDs within 120 days before each event. NSAIDs significantly increased the risk of MACCEs {adjusted odds ratio [aOR] 1.37 [95% confidence interval (CI) 1.26–1.50]} and mortality [aOR 1.29 (95% CI 1.22–1.36)]. Nonselective NSAIDs, but not selective cyclooxygenase-2 inhibitors, significantly increased the risk of MACCEs and mortality. However, the MACCE and mortality risk did not increase in a dose-dependent manner in the analysis according to the cumulative defined daily dosage of NSAIDs. The incidence of MACCEs in the case period tended to be more common in patients who had recent exposure to NSAIDs than in patients who did not have recent exposure to NSAIDs.

Conclusions
Clinicians should be particularly cautious when prescribing NSAIDs to dialysis patients considering the associations of NSAIDs with cardiovascular outcomes and mortality, which might occur independent of the dose and duration of exposure.
Transversely trapping surfaces: Dynamical version
Authors: Yoshino Hirotaka , Izumi Keisuke , Shiromizu Tetsuya , Tomikawa Yoshimune 
Published: December 2019

Abstract
We propose new concepts, a dynamically transversely trapping surface (DTTS) and a marginally DTTS, as indicators for a strong gravity region. A DTTS is defined as a two-dimensional closed surface on a spacelike hypersurface such that photons emitted from arbitrary points on it in transverse directions are acceleratedly contracted in time, and a marginally DTTS is reduced to the photon sphere in spherically symmetric cases. (Marginally) DTTSs have a close analogy with (marginally) trapped surfaces in many aspects. After preparing the method of solving for a marginally DTTS in the time-symmetric initial data and the momentarily stationary axisymmetric initial data, some examples of marginally DTTSs are numerically constructed for systems of two black holes in the Brill–Lindquist initial data and in the Majumdar–Papapetrou spacetimes. Furthermore, the area of a DTTS is proved to satisfy the Penrose-like inequality $A_0\le 4\pi (3GM)^2$, under some assumptions. Differences and connections between a DTTS and the other two concepts proposed by us previously, a loosely trapped surface [Prog. Theor. Exp. Phys. 2017, 033E01 (2017)] and a static/stationary transversely trapping surface [Prog. Theor. Exp. Phys. 2017, 063E01 (2017)], are also discussed. A (marginally) DTTS provides us with a theoretical tool to significantly advance our understanding of strong gravity fields. Also, since DTTSs are located outside the event horizon, they could possibly be related with future observations of strong gravity regions in dynamical evolutions.
Myofascia-dominant involvement on whole-body MRI as a risk factor for rapidly progressive interstitial lung disease in dermatomyositis
Authors: Karino Kohei , Kono Michihiro , Kono Michihito , Sakamoto Keita , Fujieda Yuichiro , Kato Masaru , Amengual Olga , Oku Kenji , Yasuda Shinsuke , Atsumi Tatsuya 
Published: December 2019

Abstract

Objective
Rapidly progressive interstitial lung disease (RPILD) is a major cause of death in patients with DM. Although clinically amyopathic DM (CADM) represents risk for RPILD, the incidence rate of RPILD in patients with CADM varies widely. Whole-body (WB) MRI can reveal involvement of systemic muscle and myofascia. The objective of this study was to explore the risk factors for RPILD in patients with DM using WB-MRI.

Methods
This retrospective study comprised 41 patients with DM who underwent WB-MRI before the initiation of treatment in our hospital. Muscular and myofascial signals were scored on 42 muscular groups. The myofascia/muscle ratio was calculated and used to define the relevance of myofascia-dominant involvement. RPILD was defined as worsening of dyspnoea, hypoxaemia and radiographic ILD/fibrosis within 3 months from the onset of respiratory symptoms.

Results
Among the 41 patients, 17 had CADM and 30 had ILD, including 10 patients with RPILD. All patients including those with CADM showed abnormal signal intensity in both muscle and myofascia (median score: 15 and 23, respectively). Muscle signal scores positively correlated with the serum creatine kinase level (r = 0.714; P&lt; 0.001). Patients with RPILD showed a significantly higher myofascia/muscle ratio than those without RPILD (1.929 vs 1.200; P= 0.027). Logistic regression analysis identified higher myofascia/muscle ratio as independent risk factors for developing RPILD.

Conclusion
Myofascia-dominant involvement was defined and appreciated in patients with DM using WB-MRI. This may be one of the risk factors for RPILD.
Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study
Authors: Blanken Tessa F , Borsboom Denny , Penninx Brenda Wjh , Van Someren Eus Jw 
Published: December 2019

Abstract

Study Objectives
Major depressive disorder (MDD) is the leading cause of disability worldwide. Its high recurrence rate calls for prevention of first-onset MDD. Although meta-analysis suggested insomnia as the strongest modifiable risk factor, previous studies insufficiently addressed that insomnia might also occur as a residual symptom of unassessed prior depression, or as a comorbid complaint secondary to other depression risks.

Methods
In total, 768 participants from the Netherlands Study of Depression and Anxiety who were free from current and lifetime MDD were followed-up for four repeated assessments, spanning 6 years in total. We performed separate Cox proportional hazard analyses to evaluate whether baseline insomnia severity, short-sleep duration, and individual insomnia complaints prospectively predicted first-onset MDD during follow-up. The novel method of network outcome analysis (NOA) allowed us to sort out whether there is any direct predictive value of individual insomnia complaints among several other complaints that are associated with insomnia.

Results
Over 6-year follow-up, 141 (18.4%) were diagnosed with first-onset MDD. Insomnia severity but not sleep duration predicted first-onset MDD (HR = 1.11, 95% CI: 1.07–1.15), and this was driven solely by the insomnia complaint difficulty initiating sleep (DIS) (HR = 1.10, 95% CI: 1.04–1.16). NOA likewise identified DIS only to directly predict first-onset MDD, independent of four other associated depression complaints.

Conclusions
We showed prospectively that DIS is a risk factor for first-onset MDD. Among the different other insomnia symptoms, the specific treatment of DIS might be the most sensible target to combat the global burden of depression through prevention.
Sex differences within sleep in gonadally intact rats
Authors: Swift Kevin M , Keus Karina , Echeverria Christy Gonzalez , Cabrera Yesenia , Jimenez Janelly , Holloway Jasmine , Clawson Brittany C , Poe Gina R 
Published: December 2019

Abstract
Sleep impacts diverse physiological and neural processes and is itself affected by the menstrual cycle; however, few studies have examined the effects of the estrous cycle on sleep in rodents. Studies of disease mechanisms in females therefore lack critical information regarding estrous cycle influences on relevant sleep characteristics. We recorded electroencephalographic (EEG) activity from multiple brain regions to assess sleep states as well as sleep traits such as spectral power and interregional spectral coherence in freely cycling females across the estrous cycle and compared with males. Our findings show that the high hormone phase of proestrus decreases the amount of nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep and increases the amount of time spent awake compared with other estrous phases and to males. This spontaneous sleep deprivation of proestrus was followed by a sleep rebound in estrus which increased NREM and REM sleep. In proestrus, spectral power increased in the delta (0.5–4 Hz) and the gamma (30–60 Hz) ranges during NREM sleep, and increased in the theta range (5–9 Hz) during REM sleep during both proestrus and estrus. Slow-wave activity (SWA) and cortical sleep spindle density also increased in NREM sleep during proestrus. Finally, interregional NREM and REM spectral coherence increased during proestrus. This work demonstrates that the estrous cycle affects more facets of sleep than previously thought and reveals both sex differences in features of the sleep–wake cycle related to estrous phase that likely impact the myriad physiological processes influenced by sleep.
Overcoming cultural barriers to implementing oral HIV self-testing with high fidelity among Tanzanian youth
Authors: Catania Joseph A , Huun Cassidy , Dolcini M Margaret , Urban Angelmary Joel , Fleury Nick , Ndyetabula Clinton , Singh Ryan , Young Amy W , Conserve Donaldson F , Lace James , Msigwa Joyce Samweli 
Published: December 2019

Abstract
Tanzanian youth have high levels of HIV risk and poor access to HIV-testing. Oral self-implemented testing (Oral-SIT) provides an alternative that reduces barriers to HIV-testing. We examined adaptations to Oral-SIT training components in a randomized experiment to evaluate a “train-the-trainer” strategy for improving comprehension of graphic training materials. Participants (N = 257, age = 14−19 years) were randomly assigned to one of two self-training conditions: graphic instruction book (GIB) or Video-GIB. Outcomes included behavioral performance fidelity, self-reported comprehension, and intentions to seek treatment. Video-GIB participants, relative to GIB-only participants, had higher performance fidelity scores, made fewer performance errors, had better instruction comprehension, and were more likely to intend to seek treatment. Oral-SIT timing errors were significantly more common among GIB-only participants.
Graphic training materials in conjunction with a “train-the-trainer” video has significant potential for increasing Oral-SIT’s reach by overcoming technological and literacy barriers.
Acute Skin Failure in the Critical Care Patient
Authors: Delmore Barbara , Cox Jill , Smith Daniel , Chu Andy S. , Rolnitzky Linda 
Published: December 2019

ABSTRACT

OBJECTIVE
The purpose of this research was to build on previous work regarding predictive factors of acute skin failure (ASF) in the critically ill population.

METHODS
Researchers conducted a retrospective case-control study with a main and validation analysis. Data were extracted from the New York Statewide Planning and Research Cooperative System. For the main analysis, there were 415 cases with a hospital-acquired pressure injury (HAPI) and 194,872 controls without. Researchers then randomly selected 100 cases with a HAPIs and 300 controls without for the validation analysis. A step-up logistic regression model was used. Researchers generated receiver operating characteristic curves for both the main and validation analyses, assessing the overall utility of the regression model.

RESULTS
Eleven variables were significantly and independently related to ASF: renal failure (odds ratio [OR], 1.4, P = .003), respiratory failure (OR, 2.2; P = < .001), arterial disease (OR, 2.4; P = .001), impaired nutrition (OR, 2.3; P = < .001), sepsis (OR, 2.2; P = < .001), septic shock (OR, 2.3; P = < .001), mechanical ventilation (OR, 2.5; P = < .001), vascular surgery (OR, 2.2; P = .02), orthopedic surgery (OR, 3.4; P = < .001), peripheral necrosis (OR, 2.5; P = .003), and general surgery (OR, 3.8; P = < .001). The areas under the curve for the main and validation analyses were 0.864 and 0.861, respectively.

CONCLUSIONS
The final model supports previous work and is consistent with the current definition of ASF in the setting of critical illness.
Angiotensin–neprilysin inhibition confers renoprotection in rats with diabetes and hypertension by limiting podocyte injury
Authors: Uijl Estrellita , ‘t Hart Daan C. , Roksnoer Lodi C.W. , Groningen Marian C. Clahsen-van , van Veghel Richard , Garrelds Ingrid M. , de Vries René , van der Vlag Johan , Zietse Robert , Nijenhuis Tom , Joles Jaap A. , Hoorn Ewout J. , Danser A.H. Jan 
Published: December 2019

Objectives:
Combined angiotensin receptor--neprilysin inhibition (ARNI) reduces glomerulosclerosis better than single angiotensin receptor blockade (ARB) in diabetic, hypertensive rats. The renoprotective mechanism remains unknown, but may depend on superior blood pressure control, improved renal hemodynamics, suppressed renal inflammation or prevention of podocyte loss.

Methods:
To address this, TGR(mREN2)27 rats (a model of angiotensin II-dependent hypertension) were made diabetic for 12 weeks and treated with vehicle (n = 10), valsartan (ARB; n = 7) or sacubitril/valsartan (ARNI; n = 8) for the final 3 weeks. Arterial pressure was measured via radiotelemetry.

Results:
Sacubitril/valsartan lowered mean arterial pressure by −50 ± 4 mmHg and valsartan by −43 ± 4 mmHg (P = 0.3). Both treatments lowered albuminuria, but only sacubitril/valsartan maintained high urinary atrial natriuretic peptide, improved glycemic control and protected podocyte integrity, reflected by increased nephrin expression and suppression of transient receptor potential canonical 6 and regulator of calcineurin 1. This resulted in markedly reduced glomerulosclerosis (P < 0.05 vs. control and valsartan). Despite higher effective renal plasma flow and glomerular filtration rates, sacubitril/valsartan did neither improve filtration fraction nor renal immune cell infiltration.

Conclusion:
Sacubitril/valsartan offers drug-class-specific renoprotection in a preclinical model of diabetes and hypertension. Renoprotection is unrelated to antihypertensive efficacy, renal hemodynamics or inflammation, but may be related to protective effects of natriuretic peptides on podocyte integrity.
Drug-Induced Extrapyramidal Symptoms at the Pediatric Emergency Department
Authors: Chang Ming-Yu , Lin Kuang-Lin , Wang Huei-Shong , Wu Chang-Teng 
Published: December 2019

ObjectivesExtrapyramidal symptoms (EPS) induced by pharmacologic agents can cause patient discomfort and lead to emergency department visits. Analyzing these cases at a pediatric emergency department may help to elucidate the characteristic features of extrapyramidal syndrome in children.MethodsThis retrospective study was conducted at Chang Gung Memorial Hospital in Taiwan. Pediatric patients with drug-induced extrapyramidal syndrome seeking treatment at our emergency department from January 2001 to December 2010 were enrolled. The patients' clinical features, drug history, demographic data, and treatment data were collected and analyzed.ResultsOne hundred nineteen patients (61 females, 58 males) were enrolled. Ninety-six patients could provide their drug history; all of whom took dopamine antagonists and 90% of whom took dopamine antagonists as antiemetic agents, with only 9 patients taking them for antipsychotic purposes. Metoclopramide syrup overdose was the main cause of extrapyramidal syndrome in patients under 2 years old. The average emergency room stay of the patients who could provide their drug history was shorter than that of those who could not.ConclusionsIt is not uncommon for patients with drug-induced EPS to present to a pediatric emergency room owing to the use of dopamine antagonists as antiemetic agents. Clinical symptoms with a clear drug history are helpful for the diagnosis and management. Emphasizing the correct usage of liquid medications will reduce the risk of EPS.
Incidence and Imminence of Pregnancy in At-Risk Teens After Emergency Department Visits
Authors: Smith Alla Lescure , Chen Lei 
Published: December 2019

Background
Interventions aimed at reducing teen pregnancy rates in the United States have focused on clinics and schools. Teens disproportionately seek care in emergency departments (EDs), making these an important and understudied arena for interventions to prevent subsequent unwanted pregnancies. Establishing the risk of subsequent pregnancy (SP) in this population is a necessary prelude to effective interventions. Therefore, we set out to measure the incidence and imminence of pregnancy in sexually active teens after an ED visit.

Methods
A medical record review was conducted in an urban medical center with a general ED and a pediatric ED. Subjects were included if they were female individuals aged 13 to 19 years, were tested for gonorrhea and chlamydia in the EDs from 2004 to 2006, and were patients in the primary care clinics at the affiliated institution. Subsequent pregnancies were determined from the primary clinic charts. The duration of follow-up was 4 years.

Results
Three hundred ninety-eight subjects were included in the study. The mean age at ED visit was 17.3 years. A majority (70.1%) had a documented SP. For patients with an SP, the mean interval from ED visit to conception was 15.8 months. Patients who had an SP were significantly more likely to be an ethnic minority, to have tested positive for gonorrhea, and to have visited the adult ED.

Conclusions
In this population of sexually active teens, 70.1% became pregnant within 4 years of being tested for gonorrhea and chlamydia in the ED. The encounter in the ED represents a potential opportunity for pregnancy-prevention interventions.
Improving Resident Well-Being During Shiftwork
Authors: Levin Helen , Lim Rodrick , Lynch Timothy , Sangha Gurinder 
Published: December 2019

Purpose
The objective of this study is to quantitatively evaluate the well-being of residents doing casino shifts compared with those doing standard overnight shifts while working in an academic pediatric emergency department.

Methods
A randomized prospective survey study was performed over a period of 1 year on all residents who were scheduled to complete a 28-day block. Each block (28-day period) within the year was designated as either a “standard” or “casino” block. The standard overnight shifts were scheduled from midnight to 0800 hours, and casino shifts occurred from either 2000 to 0400 hours (casino A) and 0400 to 1200 hours (casino B). Participating residents were asked to complete both a preblock and postblock survey. The primary outcome was defined as differences in resident well-being as assessed by the brief resident wellness profile (BRWP). A mood faces graphical rating item to assess overall mood was used as a secondary outcome measures as well as a 10-item survey based on World Health Organization domains for quality of life and adapted to reflect completion of shiftwork.

Results
A total of 124 (90%) of 138 residents completed the study and were included in the analysis. No significant difference in resident well-being measured by BRWP between those in the standard and casino shift groups (17 ± 2.5 for preblock standard and 16.9 ± 2.8 for casino, P = 0.904; 17.1 ± 2.7 for postblock standard and 17.2 ± 3.1 for casino, P = 0.817), or in the relative change of the BRWP preblock and postblock between the 2 groups (standard, 0.35 ± 2.7; casino, 0.29 ± 3.0; P = 0.926). No significant difference in the mood faces rating scale scores or the 10-item postblock survey was found.

Conclusions
In the first study examining the effects of casino shifts on trainees, we found no effect of standard overnight versus casino shifts on their well-being. This counters the benefits previously seen in emergency department consultant staff and highlights the need for more studies specifically in trainees.