bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Analysis and Bayesian Model Averaging of CMIP6 Precipitation in the Nile River Basin
Authors: Ombadi Mohammed , Nguyen Phu , Sorooshian Soroosh , Hsu Kuo-lin 
Published: November 2020

AbstractThe Nile River basin is one of the global hotspots vulnerable to climate change impacts because of a fast-growing population and geopolitical tensions. Previous studies demonstrated that general circulation models (GCMs) frequently show disagreement in the sign of change in annual precipitation projections. Here, we first evaluate the performance of 20 GCMs from phase six of the Coupled Model Intercomparison Project (CMIP6) benchmarked against a high-spatial-resolution precipitation dataset dating back to 1983 from Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR). Next, a Bayesian model averaging (BMA) approach is adopted to derive probability distributions of precipitation projections in the Nile basin. Retrospective analysis reveals that most GCMs exhibit considerable (up to 64% of mean annual precipitation) and spatially heterogenous bias in simulating annual precipitation. Moreover, it is shown that all GCMs underestimate interannual variability; thus, the ensemble range is underdispersive and is a poor indicator of uncertainty. The projected changes from the BMA model show that the value and sign of change vary considerably across the Nile basin. Specifically, it is found that projected changes in the two headwaters basins, namely, the Blue Nile and Upper White Nile, are 0.03% and −1.65%, respectively; both are statistically insignificant at α = 0.05. The uncertainty range estimated from the BMA model shows that the probability of a precipitation decrease is much higher in the Upper White Nile basin whereas projected change in the Blue Nile is highly uncertain both in magnitude and sign of change.
Nordic Seas Hydrography in the Context of Arctic and North Atlantic Ocean Dynamics
Authors: Kenigson J. S. , Timmermans M.-L. 
Published: November 2020

AbstractThe hydrography of the Nordic seas, a critical site for deep convective mixing, is controlled by various processes. On one hand, Arctic Ocean exports are thought to freshen the North Atlantic Ocean and the Nordic seas, as in the Great Salinity Anomalies (GSAs) of the 1970s–1990s. On the other hand, the salinity of the Nordic seas covaries with that of the Atlantic inflow across the Greenland–Scotland Ridge, leaving an uncertain role for Arctic Ocean exports. In this study, multidecadal time series (1950–2018) of the Nordic seas hydrography, Subarctic Front (SAF) in the North Atlantic Ocean [separating the water masses of the relatively cool, fresh Subpolar Gyre (SPG) from the warm, saline Subtropical Gyre (STG)], and atmospheric forcing are examined and suggest a unified view. The Nordic seas freshwater content is shown to covary on decadal time scales with the position of the SAF. When the SPG is strong, the SAF shifts eastward of its mean position, increasing the contribution of subpolar relative to subtropical source water to the Atlantic inflow, and vice versa. This suggests that Arctic Ocean fluxes primarily influence the hydrography of the Nordic seas via indirect means (i.e., by freshening the SPG). Case studies of two years with anomalous NAO conditions illustrate how North Atlantic Ocean dynamics relate to the position of the SAF (as indicated by hydrographic properties and stratification changes in the upper water column), and therefore to the properties of the Atlantic inflow and Nordic seas.
Profile of Patients Seen in Consultation-Liaison Psychiatry in India: A Systematic Review
Authors: Dua Devakshi , Grover Sandeep 
Published: November 2020

Objectives: This review aimed to evaluate all the published studies from India conducted in the consultation-liaison (CL) psychiatry setting to identify the diagnostic patterns and referral rates in this setting. Understanding the same can help in organizing the services and knowing the training needs. Materials and Methods: A thorough literature search was done in August 2020 using different search engines (PubMed, Medknow, and Google Scholar). This was followed by an individual search of various Indian Psychiatry journals and a hand search of references in the available articles. Only those studies that described patients referred to psychiatry services from various specialties were included. Results: A total of 33 studies were selected for the review. More than half of them were published in the last 5 years. Studies have primarily reported psychiatric profile medically ill inpatients referred to CL psychiatry services, with the majority of the studies reporting the number of patients seen for the duration of at least 1 year. The referral rates for inpatients across different institutes have varied from 0.01% to 3.6%. The referral rates from emergency set-ups have varied from 1.42% to 5.4%, and in outpatients, from 0.06% to 7.17%. The most commonly diagnosed psychiatric disorders across different studies include depression; organic disorders, including delirium; substance use; intentional self-harm; and anxiety disorders. Conclusions: A limited number of studies have reported the profile of patients seen in CL psychiatry setups. Available data from these studies suggest that referral rates to psychiatry services from other specialists are dismal. There is an urgent need to change the focus of psychiatry training at both undergraduate and the postgraduate levels to enhance the psychiatric knowledge of physicians to improve psychiatry referrals.
Caregiver Satisfaction and Effectiveness of Teleconsultation in Children and Adolescents With Migraine During the Ongoing COVID-19 Pandemic
Authors: Sharawat Indar Kumar , Panda Prateek Kumar 
Published: November 2020

Background: The ongoing COVID-19 pandemic and the lockdown measures have forced clinicians across the world to look on telemedicine. Although migraine as such seems an ideal option for telemedicine, a systematic study reviewing feasibility, efficacy, and advantages of current advanced telecommunication technologies in children with migraine is lacking. Methods: Clinical details of telephonic consultations performed between March 25 and June 4, 2020, including migraine characteristics, analgesic/prophylactic drug regimens, headache frequency/severity/disability, compliance, drug-related/unrelated adverse effects and unavailability of drugs were recorded. Suitable change in the dose/commercial brand of drug regimen and the addition of new drugs were done as required. Voice call, text messages, picture/video messages, and all other possible measures were used to accumulate maximum clinical information in real time. Unless contacted for trivial reasons, most children were later followed up telephonically to ensure health care concern was resolved and to fill up one 6-item trichotomous quality control questionnaire. Results: A total of 146 telephone consultations were performed in 51 participants. Thirty-six patients were identified to have 42 significant clinical events (worsening clinical status/partial response to medications [18; 44%], drug-related adverse effects [10; 19%], unrelated systemic complaints [7; 13%], and worsening of headache due to stress/triggers [7; 13%]). In the rest of the patients, the query of the caregiver included concern regarding COVID-19–related symptoms. Twenty-nine children required increment in drug dose or addition of new drug or commercial brand. Around 90% of caregivers were satisfied with the quality of teleconsultation. Conclusion: Teleconsultation is a feasible and efficacious option, with excellent caregiver satisfaction for children with migraine.
Minimally Invasive vs Open Akin Osteotomy
Authors: Schilde Sebastian , Delank Karl-Stefan , Arbab Dariusch , Gutteck Natalia 
Published: November 2020

Background: Minimally invasive techniques of Akin osteotomy have grown in popularity, as early results suggest faster recovery, earlier return to work, and minimized wound healing problems. Preserving lateral cortex integrity during first phalanx osteotomy thereby presents a challenge because of the lack of direct visual control. This retrospective comparative study investigated clinical and radiographic outcomes of minimally invasive and open Akin osteotomy with different fixation methods and analyzed whether or not intraoperative violation of the lateral cortex caused loss of correction or delayed bone healing. Methods: One hundred eighty-four patients (210 feet) with symptomatic hallux valgus and pathologic interphalangeal angle (IPA) of at least 10 degrees underwent surgery combined with Akin osteotomy. Minimally invasive Akin osteotomies were fixed in 124 feet with 2 crossing percutaneous K-wires and compared to 86 Akin osteotomies by open technique with double-threaded (head and shank) screw fixation. At 1 day and 6 and 12 weeks postoperatively, IPA and bony consolidation were radiographically and clinically assessed. Results: Mean preoperative IPA was 13.4 ± 3.6 degrees in minimally invasive (MI) and 13.3 ± 3.5 degrees in open surgery (OS) cases ( P > .05). Intraoperative breach of the lateral cortex occurred in 12 (13.9%) in OS and 64 (51.6%) in MI cases. Whereas the breach occurred in open technique mainly during manual correction by applying a medial closing force, it was caused predominantly by the use of the burr in minimally invasive technique. After 12 weeks, the mean IPA was 4.1 ± 1.4 degrees in MI and 4.8 ± 1.2 degrees in OS cases ( P > .05). Bony consolidation was complete after 6 and 12 weeks in OS and MI, respectively. Three deep infections occurred in the OS Group after Lapidus arthrodesis and 2 deep infections were registered in the MI Group after minimally invasive chevron and Akin osteotomy. The infections were not at the site of the Akin osteotomy. Conclusion: Breach of the lateral cortex did not impair bone healing or correction of IPA. Minimally invasive Akin osteotomy with K-wire fixation provided equivalent correction of IPA compared to open surgery with screw fixation. Level of Evidence: Level III, retrospective comparative series.
Rescue therapy with thrombolysis in patients with severe COVID‐19‐associated acute respiratory distress syndrome
Authors: Price Laura C. , Garfield Benjamin , Bleakley Caroline , Keeling Archie G.M. , McFadyen Charles , McCabe Colm , Ridge Carole A. , Wort Stephen J. , Price Susanna , Arachchillage Deepa J. 
Published: November 2020

Acute respiratory distress syndrome in patients with Coronavirus disease 19 is associated with an unusually high incidence of pulmonary embolism and microthrombotic disease, with evidence for reduced fibrinolysis. We describe seven patients requiring invasive ventilation for COVID‐19‐associated acute respiratory distress syndrome with pulmonary thromboembolic disease, pulmonary hypertension ± severe right ventricular dysfunction on echocardiography, who were treated with alteplase as fibrinolytic therapy. All patients were non‐smokers, six (86%) were male and median age was 56.7 (50–64) years. They had failed approaches including therapeutic anticoagulation, prone ventilation (n = 4), inhaled nitric oxide (n = 5) and nebulised epoprostenol (n = 2). The median duration of mechanical ventilation prior to thrombolysis was seven (5–11) days. Systemic alteplase was administered to six patients (50 mg or 90 mg bolus over 120 min) at 16 (10–22) days after symptom onset. All received therapeutic heparin pre‐ and post‐thrombolysis, without intracranial haemorrhage or other major bleeding. Alteplase improved PaO2/FiO2 ratio (from 97.0 (86.3–118.6) to 135.6 (100.7–171.4), p = 0.03) and ventilatory ratio (from 2.76 (2.09–3.49) to 2.36 (1.82–3.05), p = 0.011) at 24 h. Echocardiographic parameters at two (1–3) days (n = 6) showed right ventricular systolic pressure (RVSP) was 63 (50.3–75) then 57 (49–66) mmHg post‐thrombolysis (p = 0.26), tricuspid annular planar systolic excursion (TAPSE) was unchanged (from 18.3 (11.9–24.5) to 20.5 (15.4–24.2) mm, p = 0.56) and right ventricular fractional area change (from 15.4 (11.1–35.6) to 31.2 (16.4–33.1)%, p = 0.09). At seven (1–13) days after thrombolysis, using dual energy computed tomography imaging (n = 3), average relative peripheral lung enhancement increased from 12.6 to 21.6% (p = 0.06). In conclusion, thrombolysis improved PaO2/FiO2 ratio and ventilatory ratio at 24 h as rescue therapy in patients with right ventricular dysfunction due to COVID‐19‐associated ARDS despite maximum therapy, as part of a multimodal approach, and warrants further study.
Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in BCR-ABL–negative MPN in blast phase
Authors: Gupta Vikas , Kennedy James A. , Capo-Chichi Jose-Mario , Kim Soyoung , Hu Zhen-Huan , Alyea Edwin P. , Popat Uday R. , Sobecks Ronald M. , Scott Bart L. , Gerds Aaron T. , Salit Rachel B. , Deeg H. Joachim , Nakamura Ryotara , Saber Wael 
Published: November 2020

Abstract
There is a limited understanding of the clinical and molecular factors associated with outcomes of hematopoietic cell transplantation (HCT) in patients with BCR-ABL–negative myeloproliferative neoplasms in blast phase (MPN-BP). Using the Center for International Blood and Marrow Transplant Research database, we evaluated HCT outcomes in 177 patients with MPN-BP. Ninety-five (54%) had sufficient DNA for targeted next-generation sequencing of 49 genes clinically relevant in hematologic malignancies. At 5 years, overall survival (OS), cumulative incidence of relapse, and nonrelapse mortality of the study cohort was 18%, 61%, and 25%, respectively. In a multivariable model, poor-risk cytogenetics was associated with inferior OS (hazard ratio [HR], 1.71; 95% CI, 1.21-2.41) due to increased relapse (HR, 1.93; 95% CI, 1.32-2.82). Transplants using mobilized peripheral blood (PB) were associated with better OS (HR, 0.60; 95% CI, 0.38-0.96). No difference in outcomes was observed in patients undergoing HCT with PB/BM blasts &lt;5% vs those with active leukemia. Among the 95 patients with molecular data, mutation of TP53, present in 23%, was the only genetic alteration associated with outcomes. In a multivariate model, TP53-mutant patients had inferior OS (HR, 1.99; 95% CI, 1.14-3.49) and increased incidence of relapse (HR, 2.59; 95% CI, 1.41-4.74). There were no differences in the spectrum of gene mutations, number of mutations, or variant allele frequency between patients undergoing HCT with PB/BM blasts &lt;5% vs those with active leukemia. Genetic factors, namely cytogenetic alterations and TP53 mutation status, rather than degree of cytoreduction predict outcomes of HCT in MPN-BP. No meaningful benefit of conventional HCT was observed in patients with MPN-BP and mutated TP53.
DNA methylation in infants with low and high body fatness
Authors: Henriksson Pontus , Lentini Antonio , Altmäe Signe , Brodin David , Müller Patrick , Forsum Elisabet , Nestor Colm E. , Löf Marie 
Published: November 2020

Abstract

Background
Birth weight is determined by the interplay between infant genetics and the intrauterine environment and is associated with several health outcomes in later life. Many studies have reported an association between birth weight and DNA methylation in infants and suggest that altered epigenetics may underlie birthweight-associated health outcomes. However, birth weight is a relatively nonspecific measure of fetal growth and consists of fat mass and fat-free mass which may have different effects on health outcomes which motivates studies of infant body composition and DNA methylation. Here, we combined genome-wide DNA methylation profiling of buccal cells from 47 full-term one-week old infants with accurate measurements of infant fat mass and fat-free mass using air-displacement plethysmography.

Results
No significant association was found between DNA methylation in infant buccal cells and infant body composition. Moreover, no association between infant DNA methylation and parental body composition or indicators of maternal glucose metabolism were found.

Conclusions
Despite accurate measures of body composition, we did not identify any associations between infant body fatness and DNA methylation. These results are consistent with recent studies that generally have identified only weak associations between DNA methylation and birthweight. Although our results should be confirmed by additional larger studies, our findings may suggest that differences in DNA methylation between individuals with low and high body fatness may be established later in childhood.
Temporal transcriptomic differences between tolerant and susceptible genotypes contribute to rice drought tolerance
Authors: Xia Hui , Ma Xiaosong , Xu Kai , Wang Lei , Liu Hongyan , Chen Liang , Luo Lijun 
Published: November 2020

Abstract

Background
Drought-tolerance ensures a crop to maintain life activities and protect cell from damages under dehydration. It refers to diverse mechanisms temporally activated when the crop adapts to drought. However, knowledge about the temporal dynamics of rice transcriptome under drought is limited.

Results
Here, we investigated temporal transcriptomic dynamics in 12 rice genotypes, which varied in drought tolerance (DT), under a naturally occurred drought in fields. The tolerant genotypes possess less differentially expressed genes (DEGs) while they have higher proportions of upregulated DEGs. Tolerant and susceptible genotypes have great differences in temporally activated biological processes (BPs) during the drought period and at the recovery stage based on their DEGs. The DT-featured BPs, which are activated specially (e.g. raffinose, fucose, and trehalose metabolic processes, etc.) or earlier in the tolerant genotypes (e.g. protein and histone deacetylation, protein peptidyl-prolyl isomerization, transcriptional attenuation, ferric iron transport, etc.) shall contribute to DT. Meanwhile, the tolerant genotypes and the susceptible genotypes also present great differences in photosynthesis and cross-talks among phytohormones under drought. A certain transcriptomic tradeoff between DT and productivity is observed. Tolerant genotypes have a better balance between DT and productivity under drought by activating drought-responsive genes appropriately. Twenty hub genes in the gene coexpression network, which are correlated with DT but without potential penalties in productivity, are recommended as good candidates for DT.

Conclusions
Findings of this study provide us informative cues about rice temporal transcriptomic dynamics under drought and strengthen our system-level understandings in rice DT.
Differences in sarcopenia prevalence between upper-body and lower-body based EWGSOP2 muscle strength criteria: the Tromsø study 2015–2016
Authors: Johansson Jonas , Strand Bjørn Heine , Morseth Bente , Hopstock Laila Arnesdatter , Grimsgaard Sameline 
Published: November 2020

Abstract

Background
The European Working Group on Sarcopenia in Older People (EWGSOP2) recommends grip strength and chair stand tests to be used as primary defining measures. It is unclear how either test affects prevalence estimates.

Methods
This cross-sectional study involved 3498 community-dwelling participants (40–84 years) from the 7th Tromsø Study survey (2015–2016). We used grip strength, five-repetition chair stands, four-meter Walk Speed Test, Timed-Up-and-Go (TUG) and Dual-Energy X-ray Absorptiometry measurements. Data were analyzed using multiple linear regression models and ROC-curves.

Results
Probable and confirmed sarcopenia prevalence was 1.3 and 4.4% based on grip strength and chair stands, respectively. There was very low agreement between grip strength and chair stand cut-offs (κ = 0.07), with only 4.3% of participants defined as having probable sarcopenia overlapping in the two criteria. Participants with grip strength-based sarcopenia had lower mean height, weight, waist circumference, and appendicular lean mass relative to body height (ALMheight2) than non-sarcopenic participants (all p < 0.001), after adjusting for multiple covariates. Conversely, participants with chair stand-based sarcopenia had similar height, higher weight, waist circumference and body fat% compared to non-sarcopenic participants (all p < 0.05). Area-under-curves (AUCs) for TUG-time were significantly larger when using chair stand instead of grip strength cut-offs (0.86, 95% CI 0.84–0.89 vs. 0.75, 95% CI 0.69–0.83).

Conclusions
Using chair stands instead of grip strength more than doubled probable sarcopenia prevalence across all ages. The two measures defined individuals of contradictory anthropometrics, body composition, and dissimilar physical function to have probable sarcopenia. Researchers should further evaluate the consequences of using different strength measures in the EWGSOP2 definition to classify sarcopenia.
Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report
Authors: Schultz-Rogers Laura , Muthusamy Karthik , Pinto e Vairo Filippo , Klee Eric W. , Lanpher Brendan 
Published: November 2020

AbstractBackgroundDamaging variants inTRIOhave been associated with moderate to severe neurodevelopmental disorders in humans. While recent work has delineated the positional effect of missense variation on the resulting phenotype, the clinical spectrum associated with loss-of-function variation has yet to be fully defined.Case presentationWe report on two probands with novel loss-of-function variants inTRIO. Patient 1 presents with a severe neurodevelopmental disorder and macrocephaly. TheTRIOvariant is inherited from his affected mother. Patient 2 presents with moderate developmental delays, microcephaly, and cutis aplasia with a frameshift variant of unknown inheritance.ConclusionsWe describe two patients with neurodevelopmental disorder, macro/microcephaly, and cutis aplasia in one patient. Both patients have loss-of-function variants, helping to further characterize how these types of variants affect the phenotypic spectrum associated withTRIO. We also present the third reported case of autosomal dominant inheritance of a damaging variant inTRIO.