bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin is a potential therapeutic molecule for oxidative stress induced red blood cell (RBC) injury : A review
Authors: Banerjee Adrita , Chattopadhyay Aindrila , Pal Palash Kumar , Bandyopadhyay Debasish 
Published: March 2020

Red blood cells (RBCs) or erythrocytes are highly vulnerable to oxidative stress due to their absence of nuclei and mitochondria, presence of iron containing heme and high amounts of fatty acids in their uniquely constructed lipid bilayer membrane. The principal function of RBCs is to carry oxygen to tissues. Thus, RBCs have to pass through the micro-capillaries in which it requires these cells exhibits high structural deformability and great elasticity. The intact cytoskeletal architecture and proper membrane fluidity of RBCs are crucial for their deformability. Many factors can jeopardize the structural and functional harmony of RBCs. One of them is ROS which causes RBC oxidative injuries manifested by hemolytic anaemia such as occurring in β-thalassemia. Melatonin, as a potent free radical scavenger and antioxidant, can effectively protect against RBC oxidative injuries. In addition, melatonin chelates the free iron and upregulates gene expression of antioxidant enzymes of RBCs. Melatonin is synthesized and highly accumulated in RBCs to exhibit the on-site protection. All of these indicate that melatonin is a best molecule to preserve the structural and functional intactness of RBCs. This review tries to update the current development in the field and suggests the potential utility of melatonin on the RBC related disorders.
CHINA – CAMBODIA RELATIONSHIPS: PHNOM PENH as BEIJING’S PERMANENT CLIENT STATE
Authors: Candra Wiranata Kusuma Sigit 
Published: March 2020

<p>The purpose of this paper is to analyze the relationship between Cambodia and People’s Republic of China (PRC)use historical approach and secondary data regarding the topic. Although Cambodia and PRC do not share direct border, their relationship has been flourished since Cambodia gaining their independence from France in 1953 under the regime of Norodom Sihanouk until the administration of Prime Minister Hun Sen. Since then, China has been injecting Cambodia with financial aids, which helping Cambodia to establish its nation. Noting the power gap between two nations that would be complicate the relationships between two. In addition, China with its famous five peaceful coexistence has managed to build closer ties with Cambodia. This paper concluded thatafter the implementation of Belt and Road Initiative(BRI)in 2013, the relationship began to shift from China’s closest friend in Southeast Asia towards something beyond diplomatic ties, which is Cambodia as a permanent client state of PRC and has strong normative background, and the ties itself invites many critics both from regional and international. For instance, during the Disputes of South China Sea and 45th ASEAN annual meeting where Cambodia shown their firm positions in line with China. Cambodia is appeared to show its loyalty to China as a form of payback for years of Chinese financial aids and investment for decades.</p><p><strong>Keywords:</strong>Sino-Khmer ties, BRI, Chinese permanent client, and Development of Cambodia</p>
Impact of Hydrogen on the Transcriptome of Sinorhizobium meliloti 1021 Using RNA-sequencing Technology
Authors: LIU RUIRUI , LI LULU , LI ZHIYING , WANG WEIWEI 
Published: March 2020

Abstract
Hydrogen formed during nitrogen fixation in legumes can enter the surrounding soil and confer multiple benefits to crops. Here, we used Sinorhizobium meliloti 1021, whose genome was sequenced in 2001, as a model bacterium to study the relationship between the bacterium and legume. We investigated the effects of hydrogen on the gene expression in S. meliloti using RNA-sequencing technology. We identified 43 genes whose expression was altered by hydrogen treatment; among these, 39 were downregulated, and 4 were upregulated. These genes accounted for 1.5% of the total 2941 annotated genes of the S. meliloti genome. Gene ontology and pathway analyses revealed that the hydrogen-regulated genes were associated with catalytic activity and binding. Further, these genes were primarily involved in arginine, proline, and β-alanine metabolism. Real-time PCR revealed that the transcription levels of SMc02983, cyoB, cyoC, and cyoD were reduced after hydrogen treatment. These results provide a theoretical framework for exploring new metabolic pathways of S. meliloti.
ЗАКОНОДАВЧЕ РЕГУЛЮВАННЯ МИТНИХ ПРОЦЕДУР НА МОРСЬКОМУ ТРАНСПОРТІ
Authors: Х. Джемліханов Т. 
Published: March 2020

У статті досліджено законодавче регулювання митної справи в нашій державі, виокремлено вплив міжнародного права на митну сферу. Проаналізовано нормативні акти, які забезпечують здійснювати митні процедури. Висвітлено напрямки правового забезпечення на морському транспорті. Встановлено, проблема законодавчої регламентації митних процедур на морському транспорті є досить актуаль-ною, потребує всебічного дослідження, з метою розробки спрощенних, уніфікованих правил митного оформлення на морському транспорті. Морські перевезення є економічно вигідними для зьовнішньої дія-льності країн, дозволяють здійснити доставку вантажів з різних континентів, тому для цієї категорії транспорту потрібні особливі умови митного оформлення.
Ключові слова: морський транспорт, митні процедури, митне оформлення, митна справа, морські перевезення, міжнародне право, законодавчі акти
La bioética como herramienta para enfrentar el bullying en la Educación Básica Regular
Authors: Ruiz Alvarado José Rogelio 
Published: March 2020

En cualquier situación que un país enfrente y represente una problemática social, la educación será siempre una de las mejores armas de lucha para acabar con ella. La Educación Básica Regular en el Perú, ha cambiado en las últimas décadas, ahora ya no se restringe solamente a la adquisición de contenidos curriculares, sino que ahora cuenta con los llamados ejes transversales, que se convierten en un trasfondo del proceso educativo incluyendo así temas con relevancia social y orientados a la difusión de los valores y principios buscando siempre el bien común.
Los estudiantes de EBR enfrentan, además de sus propias responsabilidades académicas y los cambios propios de su etapa, una gran problemática: el acoso escolar o más conocido Bullying, el cual a través de sus distintas manifestaciones atentan directamente contra la dignidad humana de cada estudiante.
La interiorización que realizarán los estudiantes de los principios bioéticos gracias a la transversalidad en los planes educativos, permitirá que ellos mismos identifiquen qué situación representa alguna vulneración o lesión de su dignidad humana y tomar las medidas para superarlas con la ayuda de las personas preparadas para ello.
Percepción del adulto mayor sobre su interrelación familiar. Sector II del distrito La Victoria-Chiclayo-2018
Authors: Peña Soplapuco Delia , Pizarro Coronado Luz Bella , Constantino Facundo Francisca 
Published: March 2020

La presente investigación es de tipo cualitativa con abordaje metodológico de estudio de caso el cual tuvo como objetivo describir, analizar y comprender la percepción del adulto mayor sobre su interrelación familiar. Sector II del distrito La Victoria-Chiclayo-2018. Los sujetos de investigación fueron 15 adultos mayores, y 15 familiares que viven con el adulto mayor, ambas muestras fueron determinadas por la técnica de saturación y redundancia, para la recolección de datos se utilizó la entrevista semiestructurada que fue validada por juicio de expertos. Estos datos se procesaron a través del análisis de contenido temático obteniéndose cuatro categorías: El adulto mayor y su relación familiar, Apoyo de los hijos como parte importante de la relación familiar, Sintiéndose útil: Participación del adulto mayor en las actividades del hogar y Actuación del adulto mayor como consejero en la familia. En todo momento de la investigación se tuvo en cuenta los criterios de rigor éticos y científicos. Concluyendo que la mayoría de adultos mayores y familiares consideran a la relación familiar como buena salvo algunas excepciones y refieren que para que exista esta buena relación es importante que estén los elementos de afecto, comunicación y compañía los cuales deben estar entrelazados uno de los otros, también el apoyo de los hijos a los padres es importante, como el permitir que el adulto mayor realice actividades dentro del hogar y lo más relevante es que son considerados como consejeros y orientadores en el seno familiar.
Palabras claves: Percepción, anciano, interrelación, familia
DEL ACTIVISMO A LA DEMIURGIA JUDICIAL: ¿CUÁL ES EL VALOR REAL DE UN TRATADO INTERNACIONAL DE DERECHOS HUMANOS?
Authors: Bazán José Luis 
Published: March 2020

La práctica, cada vez más extendida en los tribunales internacionales de derechos humanos, de superar la letra y el espíritu de los tratados internacionales que han de interpretar, y de reconfigurar unilateralmente su contenido obligacional sin respetar los procedimientos previstos de reforma, está modificando sustancialmente el derecho internacional de los derechos humanos. La interpretación se convierte, de este modo, en una práctica demiúrgica que crea ex novo y sin fundamento legal nuevos derechos (o incluso, pretendidos e inexistentes “derechos”) que no sólo no se contienen en los tratados, sino que, en no pocos casos, pueden minar seriamente el contenido sustancial de derechos explícita y generalmente reconocidos como fundamentales. La incertidumbre jurídica y los altos riesgos de interpretación ideológica y arbitraria de los derechos que genera este activismo judicial se añaden a la vulneración de principios tan básicos como el consentimiento del Estado Parte como fuente de obligaciones internacionales convencionales. La integridad de los derechos humanos exige que los tribunales internacionales abandonen tales prácticas arbitrarias, respeten los límites de su mandato interpretativo otorgado y dejen de operar de facto y abusivamente como órganos legisladores
IMPLICANCIAS BIOÉTICO LEGISLATIVAS DEL CONSENTIMIENTO INFORMADO EN LA REDACCIÓN DEL PROTOCOLO DE ABORTO TERAPÉUTICO
Authors: Pérez Dávila Belú Fiorella 
Published: March 2020

El aborto terapéutico es una práctica médica se encuentra despenalizada en nuestro país, y está regulada bajo un procedimiento estandarizado a nivel nacional en el comúnmente denominado Protocolo de Aborto Terapéutico (PAT), previo Consentimiento Informado (CI) de la gestante y sin incluir los derechos de su hijo. El presente artículo contiene un análisis bioético, desde las bioéticas personalista y principialista, así como legislativo del CI de la gestante regulado en el PAT, como requisito para la realización de un aborto por razones terapéuticas. Con lo cual conoceremos su grado de idoneidad, tanto desde el enfoque bioético como el legal.
Apakah Media Sosial Buruk untuk Kesehatan Mental dan Kesejahteraan? Kajian Perspektif Remaja
Authors: Sudrajat Adi 
Published: March 2020

Meskipun semakin banyak bukti tentang efek media sosial pada kesehatan mental remaja, masih ada kelangkaan penelitian empiris tentang bagaimana remaja memandang media sosial, terutama sebagai sumber pengetahuan, atau bagaimana mereka memanfaatkan wacana sosial dan media yang lebih luas untuk mengekspresikan sudut pandang. Karenanya, artikel ini berkontribusi pada literatur yang terbaru. Enam kelompok fokus berlangsung selama 3 bulan dengan 52 remaja berusia 11-18 tahun, direkrut dari sekolah-sekolah di Banyuwangi ,Jawa Timur. Analisis tematik menunjukkan bahwa remaja menganggap media sosial sebagai ancaman terhadap kesejahteraan mental dan tiga tema diidentifikasi: (1) diyakini menyebabkan gangguan mood dan kecemasan bagi beberapa remaja, (2) dipandang sebagai platform untuk cyberbullying dan (3) penggunaan media sosial itu sendiri sering dibingkai sebagai semacam 'kecanduan'
RANCANG BANGUN SISTEM INFORMASI USAHA MIKRO KECIL MENENGAH STUDI KASUS DINAS KOPERASI UMKM DAERAH ISTIMEWA YOGYAKARTA
Authors: Prabowo Annas Setiawan , Syafirullah Lutfi 
Published: March 2020

Information about UMKM is very much needed by the Cooperative Office of UMKM in determining the direction of MSME development. Accurate data will have the right impact in determining development programs and services for SMEs. The problem that often occurs in managing UMKM data and Consultation is that management is still done manually using a book, so the risk for data loss, double data, and data retrieval are difficult when data is needed quickly. So based on these problems it is necessary to have an Information System to manage MSME data. The method used is the waterfall software development method. The results of this study are systems that can facilitate datamanagement, speed up the data search process, classify according to criteria so that it can be used as a reference in the development and service of MSMEs and assist cooperative service consultants in the business consultation process.
Occurrence and genetic identification of Arcobacter butzleri in different cheese types
Authors: Elsherif Walaa Mahmoud Ali , Amin Manal Mohamed , Awaad Usama Ghareeb 
Published: March 2020

The objectives of this study were to investigate the presence of foodborne pathogen Arcobacter butzleri (A. butzleri) in different types of cheese (Talaga, Mozzarella and Roumy cheese - 30 each) retailed in Assiut dairy shops, Egypt and to test the antimicrobial effect of thyme (Thymus vulgaris) and its essential oil (EO) against isolated strains. The highest percentage of A. butzleri existence was noticed in Talaga cheese samples and confirmed by PCR using A. butzleri. 16S rRNA gene which at the same time, the existence of it in Roumy cheese after detected biochemically. To exam the effect of Thymus vulgaris and its EO on A. butzleri, were added at 2 and 4% concentratins during cheese manufacturing with addition of A. butzleri at 105 and the consumer accepatability was studied. The plant could prohibit the growth of organism in cheese nearly at 6th day. These results suggest that 2% of thyme plant have sufficient effect on A. butzleri with good consumer satisfaction so, it is recommended that e thyme should be used as natural food additive in dairy product in Egypt factories.
THE IMPACT OF UNCERTAINTY ON THE FORECAST RESEARCH METHODS OF FUEL AND ENERGY COMPLEX
Authors: Kononov Dmitriy 
Published: March 2020

A step-by-step approach to narrowing the uncertainty of long-term fuel and energy
sector development is proposed. The forecast of prices and demand in the energy markets, as well as
the identification of possible barriers and restrictions on the pace of development of the energy sector
systems.
MUTUAL ELECTROMAGNETIC INFLUENCES IN TRACTION NETWORKS WITH THE SCREENING AND STRENGTHENING WIRES
Authors: Nguen Ty 
Published: March 2020

Results of the researches directed to development of computer models of the tractive networks equipped with the screening and strengthening wires (SSW) are provided. On the basis
of simulation it is shown that application of the split SSW allows to reduce value of the directed tension
more than twice.
PRIVATE ASSESSMENT OF THE COMPETENCE OF THE STUDENT
Authors: Temnikova Elena 
Published: March 2020

The competence approach to assessing the level of the student's education within
the framework of the educational program is considered and a description of the computer program
developed by the authors is worked out, the algorithm of which is based on the evaluation of the «indicator» of the competence level and the «private evaluation» obtained in the students study of the discipline provided in the curriculum.
The Holy Alliance: Prerequisites, Creation and Plans for Establishing International Law
Authors: Ostashova Valeriia , Lypii Yevheniia , Pyvovar Artem 
Published: March 2020

The article describes the prerequisites, the creation and the plans of the Holy Alliance to establish international law and order. The end of the Napoleonic wars was marked by the Congress of Vienna. Its participants sought to restore the rule of the nobility in the conquered states of Napoleon. Based on the so-called principle of legitimacy, Congress supported the restoration on the thrones of former dynasties and noble orders in many countries. In the first place, each of the participating countries sought to meet their invasive goals, to profit from the redistribution of Europe and the colonies. In order to consolidate the conquests of, Alexander I initiated the formation of a permanent organization – the Holy Alliance. It was a kind of ideological and military-political superstructure over the “Viennese system” of diplomatic relations, founded under the guise of Christianity.
The text of the union treaty in its form and content was atypical, unlike other international agreements. This has led many international law professionals to treat it as a declaration. The organization had existed until the mid-19th century before the Crimean War, although contradictions in the alliance have been around since the 1920s.
The treaty of the Holy Alliance was concluded in Paris on September 14 (26) 1815 by the governments of Russia, Austria and Prussia. It was a rather vague statement about the mutual assistance and cooperation of all Christian states.
Under the terms of the treaty, everyone who recognized him could join the alliance. After approval, almost all European rulers, except the Pope, the head of the Christian world who considered his signature superfluous, and the Turkish Sultan who professed Islam, joined him. England also did not join the alliance, though proposals from the founders were. It should be said that in England, the treaty was treated with the greatest caution. The absence of the Holy See’s signature in England did not prevent her from being an active participant in all its congresses.
The original task of the Holy Alliance was to fulfill the role of a communication platform in which the leading powers of the world would coordinate their actions to ensure peace in Europe, preventing aggression that could harm the security of international law and order on the continent. With varying success, but in the first years of existence of the alliance these goals were achieved.
The Holy Alliance was the first collective security institution in the world after the Napoleonic wars.
Legal artefacts and the cultural code of law
Authors: Ryazanov Mykhailo 
Published: March 2020

Updating issues related to the issue of legal heritage, its constituents, its place and role in the development of law, directly related to the phenomenon of the cultural code of law and legal mentality. The legal heritage focuses on a special set of inside information that fills the content of modern legal life in its statics and dynamics.
The idea of a legal culture is considered as an expression of one form of meaningful activity of people, which is to achieve a certain purpose. An example is the refraction of individual facts, knowledge, skills, which form the image of law in a person, which in the process of conscious interpretation and systematic repetition of the same practices, form legal experience, which is transformed into a higher form of assessment of legal facts, phenomena, events.
Representing the basis of legal culture - the cultural code of law is a semiotic "matrix" of vital content, concentrated in the legal heritage, which in the process of professional lawyers activity will be filtered, the new will "erase" the previous, or adapt it to current conditions and broadcast into the future.
For the legal culture, it is significant the correlation between codes (signaling) and how they are used (communication). In this context, the codes or the contents contained therein perform a signifying function, that is, a designation of legal phenomena. This happens with the rules of law, legal institutions, legal myths, rituals, any legal artifacts, the significance of which performs the inherent function of preserving and transmitting legal information to the addressee (social subject), and he perceives it, interpreting in their own actions and actions that are also significant to other participants in the legal relationship.
The transmission of accumulated legal information is ensured by existence of the legal memory.
Legal memory is a social-legal mechanism for updating content and values that are interpreted within a specific legal space and time. Here, legal memory is not perceived as an abstract concept, but as a system of content embedded in legal artifacts. Due to them, it is realized the connection of times. They (artifacts) become a kind of memory storage, both direct and indirect, which is read through contextual connections with other artifacts.
In this way, the whole legal sphere can be regarded as an independent, single text of the legal content contained in the legal artifacts, which is united by the common cultural code and as a set of elements of the legal culture with its inherent set of codes.
Legal principles of participation of public associations in exercising public control
Authors: Gayeva Nadezhda 
Published: March 2020

It is established that the national system of legal acts that provide for public control by citizens' associations is branched out. The following regulatory acts include: 1) the Constitution of Ukraine; 2) laws; 3) by-laws; 4) international acts whose consent has been given by the Verkhovna Rada of Ukraine.
The central place in the hierarchical structure of normative legal acts on participation of public associations in exercising public control, as in all other institutions of national legislation, belongs to the Constitution of Ukraine.
Laws providing for public control by public associations are conditionally dividedinto two groups: 1) laws that directly regulate the activities of political parties, public organizations and their types, giving them certain rights by which they are able to exercise public control ; 2) laws that regulate a particular sphere of public life and grant public organizations a number of rights that enable them to participate in the exercise of public control.
It is proved that the existing normative legal acts create a legal framework for the implementation of public control by associations of citizens, as its subjects, only in certain spheres of state life and do not regulate its theoretical foundations. That is why the position of supplementing the Constitution of Ukraine, in particular its Art. 38 part three, according to which associations of citizens and individuals have the right to exercise public control. This will facilitate the rapid development of legal framework for public control.
It is proposed to envisage in the legislation on public organizations and political parties such activities as public control, which will make it possible to unambiguously state that associations of citizens are subjects of public control.
From the perspective of perspective legislation, it is argued: 1) the existence of laws regulating the exercise of public control in specific areas of public life, is not evidence of qualitative changes in the sphere of regulatory control of public control; 2) The adoption of the Law on Public Control in Ukraine, which is of universal nature, should be a logical step towards the establishment of a public control institute in Ukraine, one of the subjects of which is an association of citizens. This will lay the legal basis for a comprehensive understanding of the nature, designation and content of the Institute of Public Control and its constituents.