bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arquitectura y sal. Historia y curiosidades = Architecture and salt. History and curiosities
Authors: García Grinda José Luis 
Published: May 2020

RESUMEN:Acercamiento personal a la historia de la arquitectura de la sal, a través del estudio y documentación de ejemplos españoles. Empleamos el término arquitectura definido por William Morris (1881), en una concepción territorial incorporada en las contemporáneas definiciones patrimoniales: Paisaje Cultural (Carta de Cracovia, 2000), como el resultado y reflejo de una interacción prolongada a través de diferentes sociedades entre el hombre, la naturaleza y el medio ambiente físico. Los primeros contactos con salinas mediterráneas, como las de Cabo de Gata, la masiva presencia de fábricas de salazón romanas, como la de Sexi con origen fenicio. Salinas de mar modernas que emplean la amplitud de la marea, como Las Puntas en la isla canaria de El Hierro. Las salinas de interior, con utilización desde el neolítico y de gran importancia desde época medieval, como Poza de la Sal, Imón o Belinchón, vinculadas a trabajos de Inventario del patrimonio arquitectónico y declaraciones de BIC de los años 70 y 80 y otras investigaciones del patrimonio rural español. Su relación con la ganadería y la Mesta, su transporte histórico apoyado en la Cabaña Real de Carreteros, para detenernos en ejemplos de alfolíes y almacenes, presentes en salinas y núcleos de población. ABSTRACT:Personal approach to the history of salt architecture, supported by studies and research of Spanish examples. We use the term of Architecture used by William Morris (1881), with a territorial concept incorporated in modern heritage definitions: Cultural Landscape (Krakow Charter of 2000) First contacts with Mediterraneam salt pans, such as Cabo de Gata, the massive presence of Roman salting factories, such as Sexi with Phoenician origen. Modern sea salt pans that uses the breadth ot the tide, such as Las Puntas on the Canary island of El Hierro. Interior salt pans were used since the Neolithic and they had great importance since medieval times, such as Poza de la Sal, Imón or Belinchón. These salt pans are linked to inventory works of architectural heritage and BIC statements of the 70s and 80s and other research on Spanish rural heritage. Its relationship with livestock and the Mesta; its historical transport supported by the Cabaña Real de Carreteros. And finally stop at architecture of salt stores in salt pans and towns.
Sal y salud. Poblaciones y territorios = Salt and Health. Populations and Territories
Authors: Pozo Menéndez Elisa 
Published: May 2020

RESUMEN:El vínculo entre salud humana y medio ambiente ha adquirido en la actualidad una gran relevancia. Ya en la Antigüedad, las primeras civilizaciones estudiaban los condicionantes del entorno natural para elección de los asentamientos y ciudades. Este conocimiento tradicional se ha ido perdiendo y, muestra de ello, son las enfermedades y epidemias consecuencia de asentamientos inadecuados. En este contexto, la sal se ha utilizado a lo largo de los siglos para usos muy diversos. A medida que la medicina y las investigaciones han ido evolucionando, la sal ha adquirido igualmente una gran visibilidad en cuanto a su relación con la salud. Los hábitos de vida y consumo en la actualidad están perjudicando negativamente no solo a la salud humana, sino a la salubridad medioambiental. La puesta en valor del patrimonio, el paisaje cultural y la artesanía conecta a las personas con los territorios de una forma todavía poco explorada y que requiere mayor investigación. Este trabajo muestra la necesidad de seguir fomentando los estudios interdisciplinares y la colaboración entre distintas áreas de conocimiento, para poder comprender mejor las relaciones causa-efecto entre el medio ambiente, los territorios, hábitos y estilo de vida y la salud humana. ABSTRACT:The connection between human health and environment has recently acquired special relevance. Since antique times, first civilizations already studied environmental conditionants in order to chose the optimal place for settlements and cities. This traditional knowledge has been gradually lost and proof of that are the diseases and epidemies consequence of innacurated settlements. In this context, salt has been used during centuries with different applications. As long as medicine and scientific research have evolved, the salt and its relationship with health have become more visible. Modern lifestyles and consumption patterns are affecting negatively both human health and environmental healthiness. Emphasizing the heritage, cultural landscapes and artisan activities make people develop special connections with territories that need to be explored yet. This paper shows the interest on supporting interdisciplinary studies and collaboration between different fields, in order to better understand the relations cause-effect between environment, territories, habits and lifestyles and human health.
Identifikasi Aspek Pengembangan Kawasan Konservasi Penyu Pantai Trisik sebagai Wadah Wisata Edukasi Penyu di Kulonprogo
Authors: Darmarani Chiquita , Muqoffa Mohamad , Mustaqimah Ummul 
Published: May 2020

<p><em>Sea turtle is classified into endangered animal. One of the areas which is designated as sea turtle conservation area in Indonesia is located at Trisik Beach, Kulonprogo. The government’s sea turtle conservation effort is supported by the Penyu Abadi Conservation Group, that has been carrying out sea turtle conservation activities since 2004. By the development of this conservation activities, in 2018, Dinas Pariwisata Daerah Istimewa Yogyakarta finally planned a development program for the attractiveness of sea turtle conservation areas on the southern coast of Yogyakarta, including Trisik Beach. One form of developing the attraction of conservation areas is sea turtle educational tourism object. The development of a sea turtle conservation area into a tourist attraction for sea turtle education should not disturb the balance of the natural ecosystem of Trisik Beach sea turtle nesting. Therefore, the problem formulated in this research is what aspects must be fulfilled to realize the recreational sea turtle educational tourism, by paying attention to its main function as a supporter of regional marine conservation activities. The problem solving is done by applying the applied research methods, namely the type of research that aims to provide practical solutions for the problem. This research produced some guidelines that can be implemented in the development of Trisik Beach sea turtle conservation area, to be the basis for future development planning. </em></p>
Pengaruh Perubahan Fungsi Terhadap Tipologi Arsitektur Fasad Bangunan di Kampung Wisata Prawirotaman
Authors: Yetti Aprodita Emma , Fitria Tika Ainnunisa , Pujiyanti Indah 
Published: May 2020

<p class="Abstract"><em>The final results of this study describe the impact of changes in building functions on the facade typology in Kampung Prawirotaman. These results can be used for reference and consideration in the character and visual development of Kampung Prawirotaman. Kampung Prawirotaman is one of the tourism destination in Yogyakarta. Through a long history, Kampung Prawirotaman which is known as a batik village has been transformed into a tourism village. This area is supported by infrastructure and strategic locations. This area is close to the city center and the other tourist destinantions. Kampung Prawirotaman had an architectural heritage that form of the visual characters from the adaptation of traditional and "indis" architecture. Now, the community develop the tourism facilities as independently and spontaneously in this area. The tourism facilities has resulted in changes the various building facade elements in Kampung Prawiotaman. The research used descriptive qualitative method with architectural typology approach.</em></p>
SARS-CoV-2 Impact on Elective Orthopaedic Surgery
Authors: Jain Amit , Jain Punya , Aggarwal Shruti 
Published: May 2020

Background:
The aim of our study was to explore the impact of elective-surgery deferment on the United States health-care system and subsequent recovery after COVID-19 containment. Using an orthopaedic elective surgery model, we aimed to answer the following: (1) What is the expected recovery time until the health-care system is back to nearly full capacity for performing elective surgery? (2) What will be the expected backlog of elective surgery over time? (3) How should health care change to address the backlog?

Methods:
A Monte Carlo stochastic simulation-based analysis was performed to forecast the post-pandemic volume of elective, inpatient total joint arthroplasty and spinal fusion surgical cases. The cumulative backlog was calculated and analyzed. We tested model assumptions with sensitivity analyses.

Results:
Assuming that elective orthopaedic surgery resumes in June 2020, it will take 7, 12, and 16 months—in optimistic, ambivalent, and pessimistic scenarios, respectively—until the health-care system can perform 90% of the expected pre-pandemic forecasted volume of surgery. In the optimistic scenario, there will be a cumulative backlog of >1 million surgical cases at 2 years after the end of elective-surgery deferment.

Conclusions:
The deferment of elective surgical cases during the SARS-CoV-2 pandemic will have a lasting impact on the United States health-care system. As part of disaster mitigation, it is critical to start planning for recovery now.
Risk factors for postpartum sepsis: A nested case-control study
Authors: Bakhtawar Samina , Sheikh Sana , Qureshi Rahat , Hoodbhoy Zahra , Payne Beth , Azam Iqbal , Dadelszen Peter von , Magee Laura 
Published: May 2020

Abstract
Background: The Majority (99%) of maternal deaths occur in low and middle-income countries. The three most important causes of maternal deaths in these regions are postpartum hemorrhage, pre-eclampsia and puerperal sepsis. There are several diagnostic criteria used to identify sepsis and one of the commonly used criteria is systematic inflammatory response syndrome (SIRS). However, these criteria require laboratory investigations that may not be feasible in resource-constrained settings. Therefore, this study aimed to develop a model based on risk factors and clinical signs and symptoms that can identify sepsis early among postpartum women. Methods: A case-control study was nested in an ongoing cohort of 4000 postpartum women who delivered or were admitted to the study hospital. According to standard criteria of SIRS, 100 women with sepsis (cases) and 498 women without sepsis (controls) were recruited from January to July 2017. Information related to the socio-demographic status, antenatal care and use of tobacco were obtained via interview while pregnancy and delivery related information, comorbid and clinical sign and symptoms were retrieved from the ongoing cohort. Multivariable logistic regression was performed and discriminative performance of the model was assessed using area under the curve (AUC) of the receiver operating characteristic (ROC). Results: Multivariable analysis revealed that 1-4 antenatal visits (95% CI 0.01 - 0.62) , 3 or more vaginal examinations (95% CI 1.21 - 3.65), home delivery (95% CI 1.72-50.02), preterm delivery, diabetes in pregnancy (95% CI 1.93-20.23), lower abdominal pain (95% CI 1.15 - 3.42)) vaginal discharge (95% CI 2.97-20.21), SpO2 <93% (95% CI 4.80-37.10) and blood glucose were significantly associated with sepsis. AUC was 0.84 (95% C.I 0.80-0.89) which indicated that risk factors and clinical sign and symptoms-based model has adequate ability to discriminate women with and without sepsis. Conclusion: This study developed a non-invasive tool that can identify postpartum women with sepsis as accurately as SIRS criteria with good discriminative ability. Once validated, this tool has the potential to be scaled up for community use by frontline health care workers.
Establishment of Kidney Cancer Organoid Cultures
Authors: Bauer Daniel , Birchmeier Walter , Fendler Annika 
Published: May 2020

Abstract
This protocol describes an efficient novel method for cultivating kidney cancer organoids, derived directly from human clear cell renal cell carcinomas (ccRCC) or sorted cancer stem cells. The organoids recapitulate tumor-specific characteristics and display inter-tumor heterogeneity. Here we explain how to establish the organoid cultures, maintain them in defined, serum-free medium and use them for patient-specific drug testing. Within 10-14 days, a patient-derived organoid culture is established and can be serially passaged. Compared to other protocols focusing on organoid cultures derived from pediatric kidney malignancies or healthy kidneys, the protocol described here is optimized for adult ccRCC organoid cultures. Organoids established using this protocol can be used to further investigate tumor biology in a complex 3D in vitro system, complement current preclinical model-based drug studies, and advance the development of personalized therapy design.
Development and optimization of the demineralization process for the extraction of chitin from Omani Portunidae segnis
Authors: Shaqsi Noura Hamed Khalifa Al , Hoqani Horiya Ali Said Al Hoqani Al , Hossain Md. Amzad , Sibani Mohammed Abdullah Al 
Published: May 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Novel 61-BP Indel of the RIN2 Gene is Significantly Associated with Chicken Growth and Carcass Traits
Authors: Lin Wujian , Ren Tuanhui , Liang Jiaying , Li Wangyu , Xian Mingjian , Liu Manqing , He Danlin , Liang Shaodong , Luo Wen , Zhang Xiquan 
Published: May 2020

Abstract
Background: Ras and Rab interactor 2 (RIN2) gene, encoding RAS and Rab interacting protein 2, can interact with GTP-bound Rab5 and participate in early endocytosis. Deletion of RIN2 may impair Rab5-related endosome signaling, leading to abnormal phenotypes. However, no research has been reported on the functions of RIN2 related to animal production.Results: A 61-bp insertion/deletion (indel) in the RIN2 intron region in this study. The genotype analysis of mutation sites was performed on 550 individuals from 7 different chicken breeds, and it was found that the indel exists in each breed and the local breed chickens are mainly DD genotypes. Correlation analysis of the indel with growth traits and carcass traits of the F2 population of Xinghua and White Recessive Rock chicken showed that the RIN2 61-bp deletion mutation site was significantly correlated with abdominal fat weight, fat width and hatching weight traits (P < 0.05). RIN2 mRNA was expressed in all test tissues, and the expression level of abdominal fat was higher than that in other tissues. In addition, it was further found that the expression level of type II RIN2 mRNA in abdominal fat was significantly different from that of ID type and DD type (P < 0.05). Conclusion: The results showed that the mutation was closely related to the abdominal fat-related and hatching weight traits of chickens, which may have certain reference value for molecular marker-assisted selection of chickens.
For better response to clinical trials under public health emergency: a descriptive analysis COVID-19, SARS, MERS and Ebola intervention clinical trials registration
Authors: Xiang Yuxia , Zhang Zeyu , Zeng Chan , Hu Zhanqing , Liu Yaxin , Chen Wenjing , Huang Zhijun , Wang Xiaomin , Yang Guoping 
Published: May 2020

Abstract
BackgroundCOVID-19 is a novel and highly virulent virus, which caused a rapid and massive onset of clinical trials in a short period of time.With the aim to obtain suggestions in the guidance on performing public health emergency clinical trials, and control this virus in China and other countries and for the prevention of the onset of other infectious viruses in the future. Methods COVID-19, SARS, MERS and Ebola clinical trials registered in the Chinese clinical trial registry and clinical trials.gov were collected and analyzed and intervention protocols were descriptively analyzed, focusing on the analysis and comparison of the drug used. The search period ended on February 24, 2020.ResultsThe number of the registered COVID-19 clinical trials was 295. Among 203 intervention trials, 78.3% (159) were drug clinical trials. The 159 COVID-19 trials were designed and analyzed with the highest proportion of random, open control study [66.0% (105)], and blind randomized trials [13.8% (22)]. The drug mostly used was Lopinavir/Ritonavir (15.1%). The sample size median 100,IQR(interquartile range) 140. The number of the registered SARS was 6, MERS 15, and Ebola 97. Among 3 MERS and 19 Ebola drug intervention clinical trials, MERS and Ebola were randomized, blind, and placebo-controlled drug clinical trials accounting for 100% (3) and 31.6% (6), respectively, while SARS were vaccine trials, without drug intervention clinical trials registered.Conclusions Some of the COVID-19 clinical trials and drug selection performed are somewhat disordered, requiring greater attention to the needs, science assumptions, ethics and quality management of the clinical research. Thus, during the epidemic period, the country should deliver guidance on how to perform appropriate emergency clinical trials, design a scientifically based clinical trial program and focus on researching drugs or vaccines that have great potential.
Relationship between visceral adipose tissue and triglyceride glucose index with liver status in men and women with metabolic syndrome features: sex differences
Authors: Bullón-Vela Vanessa , Abete Itziar , Tur Josep A. , Konieczna Jadwiga , Romaguera Dora , Pintó Xavier , Corbella Emili , Martínez-González Miguel A. , Sayón-Orea Carmen , Toledo Estefanía , Corella Dolores , Macias-Gonzalez Manuel , Tinahones Francisco J. , Fitó Montserrat , Estruch Ramon , Ros Emilio , Salas-Salvadó Jordi , Daimiel Lidia , Mascaró Catalina M. , Zulet M. Angeles , Martínez J. Alfredo 
Published: May 2020

Abstract
BackgroundMetabolic syndrome (MetS) comprises several clinical and metabolic risk factors that increase the risk to develop cardiovascular disease and other comorbidities. Meanwhile, ageing and biological differences between men and women play an important role in body fat distribution and health status. The current study aimed to evaluate the association of visceral adipose tissue (VAT) and the triglyceride and glucose index (TyG) with metabolic and liver risk factors among subjects diagnosed with MetS with emphasis on differences attributable to sex.MethodsA cross-sectional study was performed including 326 individuals with MetS (54–75 years) from the PREDIMED-Plus study. Liver markers, visceral fat (VAT) and the triglyceride glucose index (TyG) were assessed. Participants were stratified according to VAT and TyG tertiles. Receiver operating characteristic (ROC) curve was used to analyze the efficiency of TyG for VAT.ResultsSubjects with greater visceral fat depots showed worse lipid profile, higher HOMA-R, TyG, ALT, fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared to participants in the 1st tertile. The multi-adjusted linear regression analyses indicated that individuals in the third tertile of TyG (> 9.1–10.7 units) had a positive association with HOMA-IR (β = 3.07 [95% CI, 2.28–3.86]; p-trend < 0.001), ALT (β = 7.43 [95%CI, 2.23–12.63]; p-trend = 0.005), GGT (β = 14.12 [95% CI, 3.64–24.61; p-trend = 0.008]), FGF-21 (β = 190.69 [95% CI, 93.13-288.25; p-trend < 0.001]), FLI (β = 18.65 [95%CI, 14.97–22.23]; p-trend < 0.001) and HSI (β = 3.46 [95% CI, 2.23–4.68; p-trend < 0.001]) versus participants from the first tertile. Interestingly, the TyG showed the largest AUC for women (AUC = 0.713; 95%CI, 0.62–0.79) compared to men (AUC = 0.570; 95%CI, 0.48–0.66), despite the differences in VAT content associated to sex.ConclusionsBoth, VAT and the TyG are strongly associated with cardiometabolic and liver risk factors linked with non-alcoholic fatty liver disease in men and women diagnosed with MetS. The TyG could be used as suitable marker estimator of VAT in women.Trial registrationRetrospectively registered at the International Standard Randomized Controlled Trial (http://www.isrctn.com/ISRCTN89898870), registration date: 24 July 2014.
A Clinical Control Study on the Retroperitoneal Laparoscopy for Unilateral Simple Renal Cyst Decortication in the Day Ward
Authors: Zhu Xiao-Liang , Bano Yasmeen , wu song-jiang , Jiang Hai-Hong 
Published: May 2020

Abstract
BackgroundUnder the constraints of the increasingly tight medical environment and market economy, day surgery has a good development trend and attracts more and more attention from clinicians. To investigate the feasibility and safety of unilateral simple renal cyst decortication by retroperitoneal laparoscopy in the day ward and to compare the advantages and disadvantages of conventional inpatient ward.MethodsA total of 41 patients with unilateral simple renal cysts meeting surgical indications were included in this study. The patients were divided into the day ward group and inpatient ward group by the patients' wishes. The indexes of operation time, time of hospitalization, intraoperative blood loss, time of postoperative extubation, postoperative complication rate, patients’ satisfaction rate, quality of life scores and total costs of hospitalization were compared between the two groups.Results41 cases of unilateral simple renal cyst decortication were completed successfully. Patients were followed up 10–12 months after surgery. CT or b-ultrasound examination indicated that the original renal cyst had been decorticated surgically and no recurrence of the cyst was observed after 10 months of postoperative follow-up. Time of postoperative extubation were (9.7 ± 1.8) hours and (20.8 ± 5.5) hours, total hospitalization costs were (5790 ± 99.8) RMB and (7496 ± 120.6) RMB, time of hospitalization were (22.7 ± 1.4) hours and (46.4 ± 11.3) hours in the day ward group and the inpatient ward group, respectively. In the above three aspects, the differences between the two groups were statistically significant (P < 0.05).ConclusionIn this study, we concluded that the retroperitoneal laparoscopy for unilateral simple renal cyst decortication in patients aged between 48 and 80 years, with no previous history of abdominal surgery, unilateral renal cysts (Bosniak grades I or II) on CT, ASA grades I or II, and no surgical or anesthetic contraindications, was safe and feasible in the day ward. Its obvious advantages of reducing time of hospitalization and total costs of hospitalization were worthy of clinical promotion.