bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder
Authors: Hamatani Sayo , Tsuchiyagaito Aki , Nihei Masato , Hayashi Yuta , Yoshida Tokiko , Takahashi Jumpei , Okawa Sho , Arai Honami , Nagaoka Maki , Matsumoto Kazuki , Shimizu Eiji , Hirano Yoshiyuki 
Published: September 2020

Abstract
Background
Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT.

Methods
Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses.

Results
Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT .

Conclusions
Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD.

Trial registration
UMIN, UMIN00024087. Registered 20 September 2016 - Retrospectively registered (including retrospective data).
Bayesian spatial analysis of socio-demographic factors influencing pregnancy termination and its residual geographic variation among ever-married women of reproductive age in Bangladesh
Authors: Zahan Rifat , Feng Cindy Xin 
Published: September 2020

Abstract
Background
Unsafe pregnancy termination is a major public health concern among reproductive-aged women in many developing countries. This study evaluated the socio-demographic characteristics, as well as residual spatial correlation in pregnancy termination among Bangladeshi women.

Methods
Secondary data was obtained from the Bangladesh Demographic and Health Survey for the survey year 2014. Data included 17,863 samples of ever-married women between the ages of 15-49 years, which is a national representative sample in Bangladesh. Bayesian spatial logistic regression was used to assess the associations between socio-demographic characteristics and pregnancy termination. We flexibly modeled the non-linear effects of the continuous covariates while accounting for residual spatial correlation at the district level.

Results
Our findings revealed that about 19% of the respondents in Bangladesh reported ever had a pregnancy terminated. The risk of pregnancy termination was higher among women who had been working, had a higher wealth index, were in a conjugal relationship, had no children, were older and started their cohabitation earlier. Residual spatial patterns revealed the areas at a higher risk of pregnancy termination, including Panchagarh, Habiganj, and Sylhet after adjusting for covariates.

Conclusions
Prevalence of pregnancy termination remains considerably high in Bangladesh. The study revealed significant associations of women’s age at survey time, age at first cohabitation, occupational status, socio-economic status, marital status and the total number of children ever born with reporting having a history of terminated pregnancy among Bangladeshi ever-married women. The identified socio-demographic characteristics and districts at an increased likelihood of pregnancy termination can inform localized intervention and prevention strategies to improve the reproductive healthcare of women in Bangladesh.
The acromioclavicular ligament shows an early and dynamic healing response following acute traumatic rupture
Authors: Maier Dirk , Tuecking Lars-Rene , Bernstein Anke , Lang Gernot , Wagner Ferdinand Christian , Jaeger Martin , Ogon Peter , Südkamp Norbert Paul , Izadpanah Kaywan 
Published: September 2020

Abstract
Purpose
Symptomatic horizontal instability is clinically relevant following acute acromioclavicular joint dislocations. However, the intrinsic healing response is poorly understood. The present study sought to investigate time-dependent healing responses of the human acromioclavicular ligament following acute traumatic rupture.

Methods
Biopsies of the acromioclavicular ligament were obtained from patients undergoing surgical treatment for acute acromioclavicular joint dislocations. Specimens were stratified by time between trauma and surgery: group 1, 0–7 days (n = 5); group 2, 8–14 days (n = 6); and group 3, 15–21 days (n = 4). Time-dependent changes in cellularity, collagen (type 1 and 3) concentration, and histomorphological appearance were evaluated for the rupture and intact zone of the acromioclavicular ligament.

Results
Group 1 was characterized by cellular activation and early inflammatory response. The rupture zone exhibited a significantly higher count of CD68-positive cells than the intact zone (15.2 vs 7.4; P ≤ 0.05). Consistently, synovialization of the rupture end was observed. Within the second week, the rupture zone was subject to proliferation showing more fibroblast-like cells than the intact zone (66.8 vs 43.8; P ≤ 0.05) and a peak of collagen type 3 expression (group 1: 2.2 ± 0.38, group 2: 3.2 ± 0.18, group 3: 2.8 ± 0.57; P ≤ 0.05). Signs of consolidation and early remodeling were seen in the third week.

Conclusions
The acromioclavicular ligament exhibits early and dynamic healing responses following acute traumatic rupture. Our histological findings suggest that surgical treatment of acute ACJ dislocations should be performed as early as possible within a timeframe of 1 week after trauma to exploit the utmost biological healing potential. Prospective clinical studies are warranted to investigate whether early surgical treatment of ACJ dislocations translates into clinical benefits.
Online Cost-Effectiveness ANalysis (OCEAN): a user-friendly interface to conduct cost-effectiveness analyses for cervical cancer
Authors: Moriña David , Martí José Ignacio , Puig Pedro , Diaz Mireia 
Published: September 2020

Abstract
Background
Most cost-effectiveness analyses in the context of cervical cancer prevention involve the use of mathematical models to simulate HPV infection, cervical disease and prevention strategies. However, it is common for professionals who would need to perform these analyses to not be familiar with the models. This work introduces the Online Cost-Effectiveness ANalysis tool, featuring an easy-to-use web interface providing health professionals, researchers and decision makers involved in cervical cancer prevention programmes with a useful instrument to conduct complex cost-effectiveness analyses, which are becoming an essential tool as an approach for supporting decision-making that involves important trade-offs.

Results
The users can run cost-effectiveness evaluations of cervical cancer prevention strategies without deep knowledge of the underlying mathematical model or any programming language, obtaining the most relevant costs and health outcomes in a user-friendly format. The results provided by the tool are consistent with the existing literature.

Conclusions
Having such a tool will be an asset to the cervical cancer prevention community, providing researchers with an easy-to-use instrument to conduct cost-effectiveness analyses.
Cost-effectiveness of the Namaste care family program for nursing home residents with advanced dementia in comparison with usual care: a cluster-randomized controlled trial
Authors: El Alili Mohamed , Smaling Hanneke J. A. , Joling Karlijn J. , Achterberg Wilco P. , Francke Anneke L. , Bosmans Judith E. , van der Steen Jenny T. 
Published: September 2020

Abstract
Background
Dementia is a progressive disease that decreases quality of life of persons with dementia and is associated with high societal costs. The burden of caring for persons with dementia also decreases the quality of life of family caregivers. The objective of this study was to assess the societal cost-effectiveness of Namaste Care Family program in comparison with usual care in nursing home residents with advanced dementia.

Methods
Nursing homes were randomized to either Namaste Care Family program or usual care. Outcome measures of the cluster-randomized trial in 231 residents included Quality of Life in Late-Stage Dementia (QUALID) and the Gain in Alzheimer Care Instrument (GAIN) for family caregivers over 12 months of follow-up. Health states were measured using the EQ-5D-3L questionnaire which were translated into utilities. QALYs were calculated by multiplying the amount of time a participant spent in a specific health state with the utility score associated with that health state. Healthcare utilization costs were estimated using standard unit costs, while intervention costs were estimated using a bottom-up approach. Missing cost and effect data were imputed using multiple imputation. Bootstrapped multilevel models were used after multiple imputation. Cost-effectiveness acceptability curves were estimated.

Results
The Namaste Care Family program was more effective than usual care in terms of QUALID (− 0.062, 95%CI: − 0.40 to 0.28), QALY (0.0017, 95%CI: − 0.059 to 0.063) and GAIN (0.075, 95%CI: − 0.20 to 0.35). Total societal costs were lower for the Namaste Care Family program as compared to usual care (− 552 €, 95%CI: − 2920 to 1903). However, these differences were not statistically significant. The probability of cost-effectiveness at a ceiling ratio of 0 €/unit of effect extra was 0.70 for the QUALID, QALY and GAIN.

Conclusions
The Namaste Care Family program is dominant over usual care and, thus, cost-effective, although statistical uncertainty was considerable.

Trial registration
Netherlands Trial Register (http://www.trialregister.nl/trialreg/index.asp, identifier: NL5570, date of registration: 2016/03/23).
Cost-effectiveness of a lifestyle intervention in high-risk individuals for diabetes in a low- and middle-income setting: Trial-based analysis of the Kerala Diabetes Prevention Program
Authors: Sathish Thirunavukkarasu , Oldenburg Brian , Thankappan Kavumpurathu R. , Absetz Pilvikki , Shaw Jonathan E. , Tapp Robyn J. , Zimmet Paul Z. , Balachandran Sajitha , Shetty Suman S. , Aziz Zahra , Mahal Ajay 
Published: September 2020

Abstract
Background
Data on the cost-effectiveness of lifestyle-based diabetes prevention programs are mostly from high-income countries, which cannot be extrapolated to low- and middle-income countries. We performed a trial-based cost-effectiveness analysis of a lifestyle intervention targeted at preventing diabetes in India.

Methods
The Kerala Diabetes Prevention Program was a cluster-randomized controlled trial of 1007 individuals conducted in 60 polling areas (electoral divisions) in Kerala state. Participants (30–60 years) were those with a high diabetes risk score and without diabetes on an oral glucose tolerance test. The intervention group received a 12-month peer-support lifestyle intervention involving 15 group sessions delivered in community settings by trained lay peer leaders. There were also linked community activities to sustain behavior change. The control group received a booklet on lifestyle change. Costs were estimated from the health system and societal perspectives, with 2018 as the reference year. Effectiveness was measured in terms of the number of diabetes cases prevented and quality-adjusted life years (QALYs). Three times India’s gross domestic product per capita (US$6108) was used as the cost-effectiveness threshold. The analyses were conducted with a 2-year time horizon. Costs and effects were discounted at 3% per annum. One-way and multi-way sensitivity analyses were performed.

Results
Baseline characteristics were similar in the two study groups. Over 2 years, the intervention resulted in an incremental health system cost of US$2.0 (intervention group: US$303.6; control group: US$301.6), incremental societal cost of US$6.2 (intervention group: US$367.8; control group: US$361.5), absolute risk reduction of 2.1%, and incremental QALYs of 0.04 per person. From a health system perspective, the cost per diabetes case prevented was US$95.2, and the cost per QALY gained was US$50.0. From a societal perspective, the corresponding figures were US$295.1 and US$155.0. For the number of diabetes cases prevented, the probability for the intervention to be cost-effective was 84.0% and 83.1% from the health system and societal perspectives, respectively. The corresponding figures for QALY gained were 99.1% and 97.8%. The results were robust to discounting and sensitivity analyses.

Conclusions
A community-based peer-support lifestyle intervention was cost-effective in individuals at high risk of developing diabetes in India over 2 years.

Trial registration
The trial was registered with Australia and New Zealand Clinical Trials Registry (ACTRN12611000262909). Registered 10 March 2011.
Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
Authors: Tamai Minori , Huang Meixian , Kagami Keiko , Abe Masako , Somazu Shinpei , Shinohara Tamao , Harama Daisuke , Watanabe Atsushi , Akahane Koshi , Goi Kumiko , Sugita Kanji , Goto Hiroaki , Minegishi Masayoshi , Iwamoto Shotaro , Inukai Takeshi 
Published: September 2020

AbstractBackgroundThe genetic variants of theARID5Bgene have recently been reported to be associated with disease susceptibility and treatment outcome in childhood acute lymphoblastic leukemia (ALL). However, few studies have explored the association of ARID5B with sensitivities to chemotherapeutic agents.MethodsWe genotyped susceptibility-linked rs7923074 and rs10821936 as well as relapse-linked rs4948488, rs2893881, and rs6479778 ofARDI5Bby direct sequencing of polymerase chain reaction (PCR) products in 72 B-cell precursor-ALL (BCP-ALL) cell lines established from Japanese patients. We also quantified theirARID5Bexpression levels by real-time reverse transcription PCR, and determined their 50% inhibitory concentration (IC50) values by alamarBlue assays in nine representative chemotherapeutic agents used for ALL treatment.ResultsNo significant associations were observed in genotypes of the susceptibility-linked single nucleotide polymorphisms (SNPs) and the relapsed-linked SNPs withARID5Bgene expression levels. Of note, IC50 values of vincristine (VCR) (median IC50: 39.6 ng/ml) in 12 cell lines with homozygous genotype of risk allele (C) in the relapse-linked rs4948488 were significantly higher (p = 0.031 in Mann–Whitney U test) than those (1.04 ng/ml) in 60 cell lines with heterozygous or homozygous genotypes of the non-risk allele (T). Furthermore, the IC50 values of mafosfamide [Maf; active metabolite of cyclophosphamide (CY)] and cytarabine (AraC) tended to be associated with the genotype of rs4948488. Similar associations were observed in genotypes of the relapse-linked rs2893881 and rs6479778, but not in those of the susceptibility-linked rs7923074 and rs10821936. In addition, the IC50 values of methotrexate (MTX) were significantly higher (p = 0.023) in 36 cell lines with lowerARID5Bgene expression (median IC50: 37.1 ng/ml) than those in the other 36 cell lines with higher expression (16.9 ng/ml).ConclusionThese observations in 72 BCP-ALL cell lines suggested that the risk allele of the relapse-linked SNPs ofARID5Bmay be involved in a higher relapse rate because of resistance to chemotherapeutic agents such as VCR, CY, and AraC. In addition, lowerARID5Bgene expression may be associated with MTX resistance.
The role of extracellular vesicles in cholangiocarcinoma
Authors: Bai Mingzhen , Fu Wenkang , Su Gang , Cao Jie , Gao Long , Huang Chongfei , Ma Haidong , Zhang Jinduo , Yue Ping , Bai Bing , Lin Yanyan , Meng Wenbo , Li Xun 
Published: September 2020

AbstractCholangiocarcinoma (CCA) is a rare tumor that arises from cholangiocytes, the epithelial cells of the bile duct. The tumor is characterized by insidious onset, high degree of malignancy, poor prognosis and high recurrence rate. Due to the lack of specific biomarkers, it is difficult to diagnose CCA early and evaluate prognosis. Extracellular vesicles (EVs), which include apoptotic bodies, microvesicles and exosomes, have emerged as having important roles in cell-to-cell communication in both normal physiology and pathological conditions. Some research has found that EVs play a crucial role in the occurrence and development of CCA. EVs can carry specific molecular substances such as nucleic acids and proteins, which have potential for the diagnosis and therapy of CCA. This article reviews the current knowledge on the role of EVs in CCA. We highlight EVs and their functions in the physiology and pathophysiology of CCA, and discuss their therapeutic potential and their role as biomarkers.
The role of extracelluar matrix in osteosarcoma progression and metastasis
Authors: Cui Juncheng , Dean Dylan , Hornicek Francis J. , Chen Zhiwei , Duan Zhenfeng 
Published: September 2020

AbstractOsteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improved 5-year survival rates for patients with localized OS from 20% to over 65%, outcomes for those with metastasis remain dismal. In addition, therapeutic regimens have not significantly improved patient outcomes over the past four decades, and metastases remains a primary cause of death and obstacle in curative therapy. These limitations in care have given rise to numerous works focused on mechanisms and novel targets of OS pathogenesis, including tumor niche factors. OS is notable for its hallmark production of rich extracellular matrix (ECM) of osteoid that goes beyond simple physiological growth support. The aberrant signaling and structural components of the ECM are rich promoters of OS development, and very recent works have shown the specific pathogenic phenotypes induced by these macromolecules. Here we summarize the current developments outlining how the ECM contributes to OS progression and metastasis with supporting mechanisms. We also illustrate the potential of tumorigenic ECM elements as prognostic biomarkers and therapeutic targets in the evolving clinical management of OS.
Protocol for the measurement of changes in knowledge and engagement in the stepped wedge cluster randomised trial for childhood obesity prevention in Australia: (Reflexive Evidence and Systems interventions to Prevent Obesity and Non-communicable Disease (RESPOND))
Authors: Whelan Jillian , Strugnell Claudia , Allender Steven , Korn Ariella R. , Brown Andrew D. , Orellana Liliana , Hayward Josh , Brown Vicki , Bell Colin , Moodie Marj , Peeters Anna , Nichols Melanie 
Published: September 2020

Abstract
Background
Community-based interventions have shown promise in addressing the childhood obesity epidemic. Such efforts rely on the knowledge of key community members and their engagement with the drivers of obesity in their community. This paper presents the protocol for the measurement and evaluation of knowledge and engagement among community leaders within a whole-of-community systems intervention across 10 large intervention communities in Australia.

Methods
We will investigate the role of stakeholder knowledge and engagement in the implementation and effectiveness of the stepped wedge cluster randomised trial in ten communities in Victoria, Australia. Data will be collected using the Stakeholder-driven Community Diffusion Survey (SDCD) to measure levels of knowledge and engagement prior to commencement (2019), across the three separate levels of governance within the intervention at five time points. Primary outcomes will be baseline overall knowledge and engagement scores across the three levels of governance and change in overall knowledge and engagement over time.

Discussion
We hypothesise there will be heterogeneity between intervention sites on levels of knowledge and engagement and that these differences will be associated with variability in implementation success.

Trial registration
Australian New Zealand Clinical Trials Registry ACTRN12618001986268. Registered on 11 December 2018
A 3D mobile positioning method based on deep learning for hospital applications
Authors: Zhang Qingqing , Wang Yuan 
Published: September 2020

AbstractIn this study, a 3D positioning method is proposed for hospital applications, such as navigation within a hospital building. It employs deep learning algorithms to analyze the received signal strength from cellular networks and Wi-Fi access points in order to estimate the positions of mobile stations. A two-stage deep learning procedure (level classification and location determination) is constructed to obtain the exact position information (building level, longitude, and latitude) in multiple-level buildings. To evaluate the performance of the proposed method, an experiment was conducted in the hospital of Xi’an Polytechnic University. In total, 36,985 records, 42 sampling location points, 28 different cellular networks, and 289 different Wi-Fi access points were considered. A deep learning neural network was trained for the first stage of level classification. Three deep learning neural networks were trained to obtain the distinct location coordinates (longitude and latitude) for three different building levels. To compare the efficacy of heterogeneous networks, three kinds of neural networks with different inputs (only cellular, only Wi-Fi APs, and a conjunction of cellular and Wi-Fi APs) were implemented. The accuracy of level classification was shown to be 100% for only Wi-Fi APs as an input. The average distance error of the location determination for different floors was 0.28 m for only Wi-Fi APs and for the conjunction of Wi-Fi APs and cellular networks in the second stage.
An improved fast transform algorithm based on adaptive hybrid channel allocation in TSCH networks
Authors: Gu Junxin , Xu Yong , Zhu Yujun , Mei Fan , Kang Longlong , Liu Yiyang 
Published: September 2020

AbstractTime Slotted Channel Hopping (TSCH) is one of the five access behavior technologies defined in the IEEE 802.15.4e standard. Research shows that the wireless sensor network with single dynamic and static channel allocation in TSCH mode has higher performance. The clogging rate results in unnecessary energy waste. Therefore, this paper proposes an adaptive hybrid channel allocation strategy (AHCA) to measure the link quality change of wireless sensor networks in TSCH mode. The strategy estimates the part of the channel quality and determines whether the node wants to transmit on this channel and the optimal channel for node information transmission. According to the change of the amount of information transmitted, the hybrid channel allocation scheme of the dynamic and static channel ratio is adaptively adjusted to reduce the energy consumption of the information transmission process. This article performs experimental simulation on Contiki-NG. The experimental results show that the proposed scheme has shorter transmission time and lower congestion rate than the single dynamic static channel allocation wireless sensor network. The more reasonable and effective measurement, analysis and use of channel resources can fundamentally increase the amount of information transfer in wireless sensor networks per unit time, and thus extend the lifetime of wireless sensor networks.