bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspective and Costing in Cost-Effectiveness Analysis, 1974–2018
Authors: Kim David D. , Silver Madison C. , Kunst Natalia , Cohen Joshua T. , Ollendorf Daniel A. , Neumann Peter J. 
Published: July 2020

Abstract
Objective
Our objective was to examine perspective and costing approaches used in cost-effectiveness analyses (CEAs) and the distribution of reported incremental cost-effectiveness ratios (ICERs).

Methods
We analyzed the Tufts Medical Center’s CEA and Global Health CEA registries, containing 6907 cost-per-quality-adjusted-life-year (QALY) and 698 cost-per-disability-adjusted-life-year (DALY) studies published through 2018. We examined how often published CEAs included non-health consequences and their impact on ICERs. We also reviewed 45 country-specific guidelines to examine recommended analytic perspectives.

Results
Study authors often mis-specified or did not clearly state the perspective used. After re-classification by registry reviewers, a healthcare sector or payer perspective was most prevalent (74%). CEAs rarely included unrelated medical costs and impacts on non-healthcare sectors. The most common non-health consequence included was productivity loss in the cost-per-QALY studies (12%) and patient transportation in the cost-per-DALY studies (21%). Of 19,946 cost-per-QALY ratios, the median ICER was $US26,000/QALY (interquartile range [IQR] 2900–110,000), and 18% were cost saving and QALY increasing. Of 5572 cost-per-DALY ratios, the median ICER was $US430/DALY (IQR 67–3400), and 8% were cost saving and DALY averting. Based on 16 cost-per-QALY studies (2017–2018) reporting 68 ICERs from both the healthcare sector and societal perspectives, the median ICER from a societal perspective ($US22,710/QALY [IQR 11,991–49,603]) was more favorable than from a healthcare sector perspective ($US30,402/QALY [IQR 10,486–77,179]). Most governmental guidelines (67%) recommended either a healthcare sector or a payer perspective.

Conclusion
Researchers should justify and be transparent about their choice of perspective and costing approaches. The use of the impact inventory and reporting of disaggregate outcomes can reduce inconsistencies and confusion.
Solid State NMR Study of the Mixing Degree Between Ginkgo Biloba Extract and a Soy-Lecithin-Phosphatidylserine in a Composite Prepared by the Phytosome® Method
Authors: Carignani Elisa , Geppi Marco , Lovati Marco , de Combarieu Eric , Borsacchi Silvia 
Published: July 2020

AbstractLeaves extract of Ginkgo biloba, known in China since the most ancient times, has been widely used in the area of senile dementia thanks to its improving effects on cognitive function. A promising formulation of this botanical ingredient consists in a Ginkgo biloba-soy-lecithin-phosphatidylserine association obtained by the Phytosome® process. The precise assessment of the mixing degree between Ginkgo biloba and soy-lecithin-phosphatidylserine in this formulation is an important piece of information for understanding the reasons of its final performances. To this aim in the present study we carried out for the first time a Solid State Nuclear Magnetic Resonance investigation on Ginkgo biloba-soy-lecithin-phosphatidylserine association, on its constituents and on a mechanical mixture. The analysis of different observables highlighted a very intimate mixing (domains of single components not larger than 60 nm) of Ginkgo biloba and soy-lecithin-phosphatidylserine in their association obtained by Phytosome® process, together with a slight modification of their molecular dynamics, not observed in the case of the mechanical mixture.
Associations between depression, height and body mass index in adolescent and adult population of Penza city and oblast, Russia
Authors: Suchomlinov Andrej , Konstantinov Vsevolod V. , Purlys Petras 
Published: July 2020

AbstractThe aim of this study was to investigate the possible associations between depression, height and body mass index (BMI) in the adolescent and adult population of Penza city and oblast, Russia. The study included 554 adults aged 16–89 years. The presence and severity of depression was evaluated using Beck’s Depression Inventory (BDI-II). The participants self-reported their height (cm) and weight (kg) and these were used to calculate their BMI (kg/m2). Significant correlations were obtained between depression and short stature in young men, depression and short stature in participants with normal BMI and depression and age in overweight participants. Young women aged 16–23 years, and older men aged 60–89 years, presented the highest and very similar depression scores with no statistically significant difference between them. Special attention should be paid in Russia to these groups due to their higher risk of depressive disorders.
Technology-mediated task-based language teaching: A research agenda
Authors: Smith Bryan , González-Lloret Marta 
Published: July 2020

AbstractThis paper discusses key concepts in the emerging field of technology-mediated task-based language teaching (TMTBLT) and provides a research agenda for moving this sub-field forward in a theoretically sound and data-driven way. We first define TMTBLT and discuss the importance of considering technological affordances and specific learning contexts when matching individual technologies with particular tasks. We then explore the notion of task, specifically task complexity and sequencing, and how the introduction of technology may interact and modify tasks' features. Next, we examine the use of mobile apps and social media within a task-based language teaching (TBLT) framework and highlight areas primed for exploration or in need of reconciliation. Finally, we call for TMTBLT studies to capture and evaluate learner process data. Within each area above we propose a series of specific research tasks that incrementally build on previous research in both face-to-face and technology-mediated environments, which may help us better understand how tasks and technologies intersect to promote language learning.
Pseudorandom hypergraph matchings
Authors: Ehard Stefan , Glock Stefan , Joos Felix 
Published: July 2020

AbstractA celebrated theorem of Pippenger states that any almost regular hypergraph with small codegrees has an almost perfect matching. We show that one can find such an almost perfect matching which is ‘pseudorandom’, meaning that, for instance, the matching contains as many edges from a given set of edges as predicted by a heuristic argument.
Petrofabrics and Seismic Properties of Himalayan Amphibolites: Implications for a Thick Anisotropic Deep Crust Beneath Southern Tibet
Authors: Li Wenjing , Zhang Junfeng , Wang Xiong , Wang Yongfeng , Wu Xiang , Hu Zhaochu 
Published: July 2020

AbstractThe bulk composition of overthickened Tibetan deep crust has been generally believed to be mafic granulite with eclogite at the lowermost crust. However, a granulitic/eclogitic deep crust is in contradiction to geological and geophysical observations in southern Tibet. Here we present petrofabrics and seismic properties of amphibolites from exhumed crustal part of the Indian plate in the eastern Himalayan syntaxis. Our results show strong fabrics of amphibole, nearly random fabrics of plagioclase and strong seismic anisotropies of amphibolites (AVp = 5.6–12.0% and Max. AVs = 5.1–7.7%). Comparing to a deep crust composed of nearly isotropic mafic granulite and weakly anisotropic eclogite, a thick amphibolitic layer in the middle‐lower crust would better account for the strong shear wave splitting (0.2–0.5 s in delay times or 4–15% in S wave anisotropy), the suture boundary parallel faster shear wave polarization, and the widespread postcollisional adakite‐like potassic rocks in southern Tibet.
Optimally Oriented Remote Triggering in the Coso Geothermal Region
Authors: Alfaro‐Diaz Richard , Velasco Aaron A. , Pankow Kristine L. , Kilb Debi 
Published: July 2020

AbstractDefining the nature of faulting, the stress needed to trigger earthquakes, and the stress state of faults remains fundamental to understanding the earthquake cycle. Studying remote dynamic triggering allows us to probe faults to systemically address the fundamental physical mechanisms of faulting. Using 13 years of data (2004–2016) from the EarthScope USArray Transportable Array and the Southern California Seismic Network, we search for remotely triggered seismicity in an extended region encompassing the Coso Geothermal Field (CGF+), California. We first apply a short term to long‐term average ratio detector to high‐pass (5 Hz) filtered waveforms spanning ±5 hr encompassing 211 M ≥ 7 global earthquakes. We visually inspect these waveforms to identify uncatalogued local earthquakes. We use the augmented local earthquake catalog to investigate remote earthquake triggering in the CGF+ region. Of the 211 remote mainshocks, we find 32 (15%) produce a statistically significant increase in seismicity following the P wave arrival in CGF+. An additional nine mainshocks had local earthquakes coincident with the surface waves passage but lacked a significant rate increase. Of the 41 (19%) triggering mainshocks, 28 and 13 exhibit instantaneous and delayed triggering, respectively. We find no correlation between triggering and mainshock depth, peak dynamic stress, nor mainshock focal mechanism type. Instead, results suggest the CGF+ may be optimally oriented for remote triggering from mainshocks in the West Pacific and South America and propose the reason for this is that the transient dynamic stresses align favorably with the local stress field (most compressive horizontal stress, SHmax) to promote triggering.
Salt Marsh Dynamics in a Period of Accelerated Sea Level Rise
Authors: Fagherazzi Sergio , Mariotti Giulio , Leonardi Nicoletta , Canestrelli Alberto , Nardin William , Kearney William S. 
Published: July 2020

AbstractSalt marshes are dynamic systems able to laterally expand, contract, and vertically accrete in response to sea level rise. Here, we present the grand challenges that need to be addressed to fully characterize marsh morphodynamics. The review focuses on physical processes and quantitative models. Without predictive models, it is impossible to determine the future marsh evolution under accelerated sea level rise. In these models, one of the challenges is to resolve both horizontal and vertical dynamics within the same framework. Vertically, the marsh has to accumulate enough material to contrast rising water levels. Horizontally, marsh erosion at the ocean side must be compensated by landward expansion in forests, lawns, and agricultural fields. The dynamics of the marsh‐upland boundary are still not fully understood and will require more research in the upcoming years. The complexity of marsh vegetation is seldom captured in predictive models of marsh evolution. More research is needed to understand the effects of each species or species assemblages on hydrodynamics and sediment transport. Here, we further advocate that a sediment budget resolving all sediment fluxes in a marsh complex is the most important metric of marsh resilience. Characterization of these fluxes will enable to connect salt marshes to other landforms and to unravel feedbacks controlling the evolution of the entire coastal system. Current models of marsh evolution rely on sparse data sets collected at few locations. Novel remote sensing techniques will provide high‐resolution spatial data that will inform a new generation of computer models.
Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
Authors: Craig Stephanie G. , Humphries Matthew P. , Alderdice Matthew , Bingham Victoria , Richman Susan D. , Loughrey Maurice B. , Coleman Helen G. , Viratham-Pulsawatdi Amelie , McCombe Kris , Murray Graeme I. , Blake Andrew , Domingo Enric , Robineau James , Brown Louise , Fisher David , Seymour Matthew T. , Quirke Phil , Bankhead Peter , McQuaid Stephen , Lawler Mark , McArt Darragh G. , Maughan Tim S. , James Jacqueline A. , Salto-Tellez Manuel 
Published: July 2020

Abstract
Background
Immunohistochemical quantification of the immune response is prognostic for colorectal cancer (CRC). Here, we evaluate the suitability of alternative immune classifiers on prognosis and assess whether they relate to biological features amenable to targeted therapy.

Methods
Overall survival by immune (CD3, CD4, CD8, CD20 and FOXP3) and immune-checkpoint (ICOS, IDO-1 and PD-L1) biomarkers in independent CRC cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.

Results
Determination of immune-cold tumours by combined low-density cell counts of CD3, CD4 and CD8 immunohistochemistry constituted the best prognosticator across stage II–IV CRC, particularly in patients with stage IV disease (HR 1.98 [95% CI: 1.47–2.67]). These immune-cold CRCs were associated with tumour hypoxia, confirmed using CAIX immunohistochemistry (P = 0.0009), which may mediate disease progression through common biology (KRAS mutations, CRIS-B subtype and SPP1 mRNA overexpression).

Conclusions
Given the significantly poorer survival of immune-cold CRC patients, these data illustrate that assessment of CD4-expressing cells complements low CD3 and CD8 immunohistochemical quantification in the tumour bulk, potentially facilitating immunophenotyping of patient biopsies to predict prognosis. In addition, we found immune-cold CRCs to associate with a difficult-to-treat, poor prognosis hypoxia signature, indicating that these patients may benefit from hypoxia-targeting clinical trials.
A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma
Authors: Luanpitpong Sudjit , Rodboon Napachai , Samart Parinya , Vinayanuwattikun Chanida , Klamkhlai Siwaporn , Chanvorachote Pithi , Rojanasakul Yon , Issaragrisil Surapol 
Published: July 2020

Abstract
Background
Calcium is an essential signal transduction element that has been associated with aggressive behaviours in several cancers. Cell motility is a prerequisite for metastasis, the major cause of lung cancer death, yet its association with calcium signalling and underlying regulatory axis remains an unexplored area.

Methods
Bioinformatics database analyses were employed to assess correlations between calcium influx channels and clinical outcomes in non-small cell lung cancer (NSCLC). Functional and regulatory roles of influx channels in cell migration and invasion were conducted and experimental lung metastasis was examined using in vivo live imaging.

Results
High expression of TRPM7 channel correlates well with the low survival rate of patients and high metastatic potential. Inhibition of TRPM7 suppresses cell motility in various NSCLC cell lines and patient-derived primary cells and attenuates experimental lung metastases. Mechanistically, TRPM7 acts upstream of O-GlcNAcylation, a post-translational modification and a crucial sensor for metabolic changes. We reveal for the first time that caveolin-1 and c-Myc are favourable molecular targets of TRPM7/O-GlcNAc that regulates NSCLC motility. O-GlcNAcylation of caveolin-1 and c-Myc promotes protein stability by interfering with their ubiquitination and proteasomal degradation.

Conclusions
TRPM7/O-GlcNAc axis represents a potential novel target for lung cancer therapy that may overcome metastasis.
Pilot study on the therapeutic potential of radiofrequency magnetic fields: growth inhibition of implanted tumours in mice
Authors: Luukkonen Jukka , Naarala Jonne , Juutilainen Jukka , Barnes Frank , Martino Carlos F. 
Published: July 2020

ABSTRACTThe present study investigated possible therapeutic effects of radiofrequency or hypomagnetic fields on the growth rate of two types of implanted tumours. To this end, mice with implanted fibrosarcoma and pancreatic tumours were exposed continuously to a 2 µT, 10 MHz radiofrequency magnetic field (MF) perpendicular to a 45 µT static MF or to a hypomagnetic (~0.4–1 µT) field. The reasoning for a 10 MHz treatment was based on a current theoretical explanation for MF effects, which predicts a resonance phenomenon in this frequency range. Radiofrequency MFs reduced consistently the growth rate of two implanted tumour types (by ~30% in both cases). Also, hypomagnetic field hindered tumour growth in both tumour types, but the observation was not statistically significant with fibrosarcoma tumours. In conclusion, although experiments included a limited number of animals, the results indicate that MFs may offer a novel therapeutic strategy in the treatment of cancer.
CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma
Authors: Fordham Ashleigh M. , Xie Jinhan , Gifford Andrew J. , Wadham Carol , Morgan Lisa T. , Mould Emily V. A. , Fadia Mitali , Zhai Lei , Massudi Hassina , Ali Zara S. , Marshall Glenn M. , Lukeis Robyn E. , Fletcher Jamie I. , MacKenzie Karen L. , Trahair Toby N. 
Published: July 2020

AbstractBackgroundEpithelioid inflammatory myofibroblastic sarcoma (eIMS) is characterised by perinuclear ALK localisation, CD30 expression and early relapse despite crizotinib treatment. We aimed to identify therapies to prevent and/or treat ALK inhibitor resistance.MethodsMalignant ascites, from an eIMS patient at diagnosis and following multiple relapses, were used to generate matched diagnosis and relapse xenografts.ResultsXenografts were validated by confirmation ofRANBP2-ALKrearrangement, perinuclear ALK localisation and CD30 expression. Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy. BV resistance was associated with reduced CD30 expression and induction of ABCB1. BV resistance was reversed in vitro by tariquidar, but combination BV and tariquidar treatment only briefly slowed xenograft growth compared with BV alone. Combining BV with either crizotinib or ceritinib resulted in marked tumour shrinkage in both xenograft models, and resulted in prolonged tumour-free survival in the diagnosis compared with the relapse xenograft.ConclusionsCD30 is a therapeutic target in eIMS. BV efficacy is limited by the rapid emergence of resistance. Prolonged survival with combination ALK and CD30-targeted-therapy in the diagnosis model provides the rationale to trial this combination in eIMS patients at diagnosis. This combination could also be considered for other CD30-positive,ALK-rearranged malignancies.
Study on electroless Cu plating quality of in situ TiCp
Authors: Zhang Dongdong , Liu Yu , Gao Yali , Wang Jinguo 
Published: July 2020

AbstractIn situ TiCp was fabricated via combustion synthesis in an Al–Ti–C system. The quality of copper plating was easily observable on the surface of spherical in situ TiCp. A study was conducted to assess the influences of the stirring method, plating temperature and particle-to-solution ratio. According to the results, magnetic stirring is an advantageous stirring method. During the plating process, the plating quality reaches the maximum level at 303 K under magnetic stirring. Moreover, uniform and dense plating is achieved when the particle-to-solution ratio reaches 1 g/100 ml. The concentration of solution and ion activity can affect the speed at which Cu2+ is attached to the growing core, which plays a significant role in the quality of copper plating.
Volatile organic compound analysis, a new tool in the quest for preterm birth prediction—an observational cohort study
Authors: Lacey Lauren , Daulton Emma , Wicaksono Alfian , Covington James A. , Quenby Siobhan 
Published: July 2020

AbstractPreterm birth is the leading cause of death worldwide in children under five years. Due to its complex multifactorial nature, prediction is a challenge. Current research is aiming to develop accurate predictive models using patient history, ultrasound and biochemical markers. Volatile organic compound (VOC) analysis is an approach, which has good diagnostic potential to predict many disease states. Analysis of VOCs can reflect both the microbiome and host response to a condition. We aimed to ascertain if VOC analysis of vaginal swabs, taken throughout pregnancy, could predict which women go on to deliver preterm. Our prospective observational cohort study demonstrates that VOC analysis of vaginal swabs, taken in the midtrimester, is a fair test (AUC 0.79) for preterm prediction, with a sensitivity of 0.66 (95%CI 0.56–0.75) and specificity 0.89 (95%CI 0.82–0.94). Using vaginal swabs taken closest to delivery, VOC analysis is a good test (AUC 0.84) for the prediction of preterm birth with a sensitivity of 0.73 (95%CI 0.64–0.81) and specificity of 0.90 (95%CI 0.82–0.95). Consequently, VOC analysis of vaginal swabs has potential to be used as a predictive tool. With further work it could be considered as an additional component in models for predicting preterm birth.
Growth and physiological responses of three warm-season legumes to water stress
Authors: Baath Gurjinder S. , Rocateli Alexandre C. , Kakani Vijaya Gopal , Singh Hardeep , Northup Brian K. , Gowda Prasanna H. , Katta Jhansy R. 
Published: July 2020

AbstractNovel drought-tolerant grain legumes like mothbean (Vigna acontifolia), tepary bean (Phaseolus acutifolius), and guar (Cyamopsis tetragonoloba) may also serve as summer forages, and add resilience to agricultural systems in the Southern Great Plains (SGP). However, limited information on the comparative response of these species to different water regimes prevents identification of the most reliable option. This study was conducted to compare mothbean, tepary bean and guar for their vegetative growth and physiological responses to four different water regimes: 100% (control), and 75%, 50% and 25% of control, applied from 27 to 77 days after planting (DAP). Tepary bean showed the lowest stomatal conductance (gs) and photosynthetic rate (A), but also maintained the highest instantaneous water use efficiency (WUEi) among species at 0.06 and 0.042 m3 m−3 soil moisture levels. Despite maintaining higher A, rates of vegetative growth by guar and mothbean were lower than tepary bean due to their limited leaf sink activity. At final harvest (77 DAP), biomass yield of tepary bean was 38–60% and 41–56% greater than guar and mothbean, respectively, across water deficits. Tepary bean was the most drought-tolerant legume under greenhouse conditions, and hence future research should focus on evaluating this species in extensive production settings.
Wet carbonate-promoted radical arylation of vinyl pinacolboronates with diaryliodonium salts yields substituted olefins
Authors: Wu Chao , Zhao Chongyang , Zhou Jun , Hu Han-Shi , Li Jun , Wu Panpan , Chen Chao 
Published: July 2020

AbstractSince the landmark work of Heck, Negishi and Suzuki on Pd-catalyzed crossing coupling reactions, innovative discovery of new reactions forming C-C bonds and constructing functional olefins via nonmetal catalysts remains an imperative area in organic chemistry. Herein, we report a transition-metal-free arylation method of vinyl pinacolboronates with diaryliodonium salts to form C(sp2)-C(sp2) bond and provide trans-arylvinylboronates. The resulting vinylboronates can further react with the remaining aryl iodides (generated from diaryliodonium salts) via Suzuki coupling to afford functional olefins, offering an efficient use of aryliodonium salts. Computational mechanistic studies suggest radical-pair pathway of the diaryliodonium salts promoted by the multi-functional wet carbonate.