bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF GENE COPY NUMBER VARIATIONS IN PATIENTS WITH CARDIAC SEPTAL DEFECTS USING MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION
Authors: YASHVANTHI BORKAR  , KRISHNANANDA NAYAK  , RANJAN SHETTY K  , RAJASEKHAR MOKA  
Published: February 2020

Objective: Cardiac septal defects (CSDs), the most common human congenital heart malformations are complex and heterogeneous. Progress in molecular biology has helped to identify many genes responsible for cardiac morphogenesis. However, etiologic factors in familial as well as isolated syndromes are being identified; the root genetic cause still needs to be resolved and its mechanism is yet to be revealed. The objective of this study is to identify DNA copy number variations (CNVs) and their possible association with septal defects.
Methods: Multiplex ligation-dependent probe amplification (MLPA) was used to detect DNA copy number in non-syndromic CSDs using the P311-A1 Kit consisting of probes for the key genes, namely, NKX2-5 (NK2 transcription factor related, locus 5), GATA4 (GATA binding protein 4), TBX5 (T-box transcription factor), bone morphogenetic protein 4, and CRELD1 (cysteine rich with EGF-like domains 1).
Results: We studied 124 clinically diagnosed CSD subjects, of which 111 (89.5%) had atrial septal defects and 13 (10.5%) had ventricular septal defects. MLPA assay was carried out in all these patients after a thorough clinical and cytogenetic screening. CNVs were identified in 16 (12.9%) cases, of which heterozygous deletions and heterozygous duplications were detected (8 patients each) with apparent phenotypes.
Conclusion: MLPA could be a useful assay for the detection of CNVs and to be adopted as the first line of screening in patients with congenital heart diseases.
SCREENING OF PHYTOCHEMICAL CONTENT AND IN VITRO BIOLOGICAL INVESTIGATION OF CANTHIUM DICOCCUM (GAERTN.) AND AMISCHOPHACELUS AXILLARIS (L.)
Authors: MEGHASHREE K S  , LATHA K P  , VAGDEVI H M  , AJISH A D  , JAYANNA N D  , ARUNKUMAR N C  
Published: February 2020

Objective: The objective of the study was to study the pet ether, ethyl acetate, and ethanol leaf extracts of Canthium dicoccum and Amischophacelus axillaris for anthelmintic activity and antihypertensive activity.
Methods: The antihypertensive activity was carried out by employing a colorimetric assay based on the hydrolysis of Histidyl-Hippuryl-Leucine and anthelmintic activity carried out against Indian earthworm Pheritimaposthuma.
Results: The pet ether leaf extract both the plants exhibited the maximum antihypertensive activity with a percent inhibition of 64.82 for C. dicoccum (Gaertn.) and 84.12 for A. axillaris (L.) as compared with Captopril showing percent inhibition 85.37 and for anthelmintic activity, it is found that ethanol extract of C. dicoccum and ethyl acetate extract of A. axillaris exhibited significant activity against the standard drug albendazole.
Conclusion: This study investigated the potential of C. dicoccum and A. axillaris as a new source against the antihypertensive activity. The outcome of anthelmintic activity revealed that the ethyl acetate and ethanol extracts exhibited a considerable amount of anthelmintic activity, which is mainly due to the active phytoconstituents present in the extracts.
IN VITRO EVALUATION OF AEGLE MARMELOS LEAF EXTRACTS ON FOOT ULCER AND URINARY TRACT INFECTED PATHOGENS FROM DIABETIC PATIENTS
Authors: MUJAWAR SALMA BEGUM HUSSAIN  , MURIGENDRA B HIREMATH  
Published: February 2020

Objective: The objective of the study was to evaluate the effect of leaf extracts on foot ulcer and urinary tract pathogens from patients having diabetes.
Methods: The pus and urine sample from the patients having diabetes were collected and cultured on nutrient agar plates. The morphological characters were studied for the colonies obtained. Antimicrobial activity of ethanol and aqueous extracts was studied for Aegle marmelos leaves.
Results: Ethanol extract exhibited good results for both foot ulcer and urinary tract infected pathogens as compared to aqueous extract. Thin-layer chromatography was performed for methanol extract and then was subjected to column chromatography. The fractions obtained were again checked for the antibacterial activity and of three fractions, fraction 1 showed better results for pus and urine pathogens. Fourier-transformed infrared analysis was carried out for fraction 1 of methanol extract for verifying the presence of bioactive compounds.
Conclusion: From the present study, it can be terminated that the bioactive compounds derived from plant extracts can be used for the development of new pharmaceutical drugs to reach out to various therapeutic needs.
Prevalencia de Burnout en auditores gubernamentales de México, perspectiva de género
Authors: Moreno Juan Carlos , Trujillo Flores Mara Maricela , Lámbarry Vilchis Fernando 
Published: February 2020

<p>Los auditores gubernamentales en México enfrentan agotadoras cargas de trabajo que más allá del cansancio físico y emocional, los predispone a ocasionarles problemas psicosociales como es el Síndrome de Quemarse por el Trabajo (SQT-<em>Burnout</em>), entre otros. No obstante, para esta profesión, el <em>burnout</em> no ha sido estudiado con profundidad como lo ha sido para algunas otras (especialmente aquellas que pertenecen al sector educativo y de la salud) y aún menos desde la perspectiva diferenciada por la variable género. El estudio cuantitativo con carácter no generalizable implicó aplicar el <em>Maslach Burnout Inventory-General Survey</em> (MBI-GS) a 557 auditores del ámbito federal y subnacional, instrumento basado en el modelo tridimensional de Maslach y Jackson que considera agotamiento emocional, sentimientos de cinismo y desapego con el trabajo y sensación de ineficacia profesional y falta de logro, la literatura especializada ha demostrado que no se trata únicamente de un fenómeno contingente. Para contrastar la hipótesis planteada Ho: las distribuciones de <em>burnout</em> entre hombres y mujeres son iguales, a través del método U de Mann-Whitney. Se concluye que en los auditores gubernamentales es mayor el <em>burnout</em> en las mujeres que en los hombres. </p>
Desarrollo financiero y desigualdad del ingreso, el caso de América Latina.
Authors: Gómez Rodríguez Tomás , Ríos Bolívar Humberto , Aali  Bujari Ali 
Published: February 2020

<p>Se analizó la relación entre desarrollo financiero y desigualdad del ingreso empleando una base de datos que comprende 13 países de América Latina, en un período que abarca del año 1990 al año 2015. La variable principal es el desarrollo financiero, la cual es medida través de la proporción crédito a PIB. Por otro lado, para medir la desigualdad del ingreso se empleó el índice de Gini. Para realizar el análisis se emplearon los siguientes métodos econométricos: efectos fijos, mínimos cuadrados generalizados estimados y el método de momentos generalizados junto con mínimos cuadrados generalizados estimados. Además, se utilizaron las siguientes variables de control: PIB per cápita, gastos del gobierno con respecto al PIB, apertura comercial, la tasa de inflación y la población. Se encontró que el desarrollo del sistema financiero incrementa la desigualdad del ingreso. Dichos resultados se validaron empleando diferentes especificaciones econométricas.<strong></strong></p>
Electronic commerce contribution to the SME performance in manufacturing firms: A structural equation model
Authors: Alderete María Verónica 
Published: February 2020

<p>The role Information and Communication Technologies (ICT) play in achieving a better organizational performance still needs further analysis among small and medium sized enterprises (SME) from developing countries. This study aims to extend the empirical literature on the relationship between ICT, electronic commerce and SME performance in developing countries. To achieve this goal, we employ a sample of 87 manufacturing firms from the city of Bahía Blanca, Argentina in the year 2015. By estimating a structural equation model, we obtain that electronic commerce adoption has a positive and significant influence on SME sales which is reinforced by the level of ICT use. Other organizational factors such as firm size and public programs explain performance, but are not significant predictors of the electronic commerce adoption. <strong></strong></p>
Integrated Green Supply Chain Model to Reduce Carbon Emission with Permissible Delay-in-Payment Consideration
Authors: Ibrahim Muhammad Faisal , Putri Maulin Masyito 
Published: February 2020

In practice, the policy of delaying payment periods is prevalent between players in a supply chain system. Generally, payments are made at the end of the permitted period. Supply chain management is one of the keys to corporate sustainability that the activities impact the environment. This paper aims to develop an integrated green supply chain model with a permissible delay in payment consideration. In this research, the author develops a mathematical model to find the effect of delay in payment on emissions costs without ignoring the economic performance of a supply chain. The author develops four different scenario models. Furthermore, numerical experiments and sensitivity analysis tests were conducted. The study results show that delay in payment is integrated into the supply chain system, which has a positive impact on reducing supply chain emissions costs.
Development of Artificial Neural Network Model for Estimation of Salt Fields Productivity
Authors: Cahyadi Indra , Ilhamsah Heri Awalul , Anna Ika Deefi 
Published: February 2020

In recent years, Indonesia needs import millions of tons of salt to satisfy domestic industries' demand. The production of salt in Indonesia is highly dependent on the weather. Therefore, this article aims to develop a prediction model by examining rainfall, humidity, and wind speed data to estimate salt production. In this research, Artificial Neural Network (ANN) method was used to develop a model based on data collected from Sumenep Madura Indonesia. The model analysis used the complete experimental factorial design to determine the effect of the ANN parameter differences. Furthermore, the selected model performance compared with the estimate predictor of Holt-Winters. The results presented that ANN-based models were more accurate and efficient for predicting salt field productivity.
Multi-Agent Simulation in the Inter-Organizational Trust Model and Knowledge Sharing in the Automotive Industry
Authors: Rizana Afrin Fauzya , Ramadhan Fadillah 
Published: February 2020

Two organizations can share knowledge to determine the success of their collaboration. Effectiveness in knowledge sharing affects organizational performance and trust between organizations. This study aims to identify the implementation of multi-agent simulations to increase trust in sharing knowledge between organizations. A multi-agent simulation approach was used in this study. The research model was adopted from previous research. Several hypotheses and path coefficients were tested in simulation models. This study showed that multi-agent simulation is suitable as a problem-solving method for complex issues such as knowledge sharing. In addition, this study identified individual factors such as likability and expertise in the success of knowledge sharing between organizations.
Biodiversitas Ikan Di Refuge Area Sungai Kapas Tengah Hutan Harapan Jambi Sebagai Database Aplikasi Go Iwak
Authors: WULANDARI TIA , Sukmono Tedjo , Kurniawan Wawan 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui biodivesitas ikan di Refuge area Sungai Kapas bagian Tengah Butan Harapan Jambi. Penelitian telah dilakukan pada Juli-Agustus 2019 di Sungai Kapas Hutan Harapan Jambi. Penentuan refuge area dilakukan dengan menyusuri Sungai Kapas bagian tengah untuk menemukan anak-anak sungai yang sudah terputus dengan Sungai kapas,, serta bagian sungai kapas serta areal lubuk di Sungai Kapas. Terdapat 4 Refufe area yang dijadikan stasiun yaitu Stasiun 1 Putusan Marihot, Stasin dua Muara Bato, Stasiun 3 Lubuk Kapas, dan Stasiun 4 Lubuk Bato. Pengambilan sampel menggunakan jala lempar , seruo, dan jaring insang, serta tray net. Hasil Penelitian didapatkan 375 ekor ikan, melputi 50 spesies, 29 genus, dan 14 famili, serta 6 ordo. Pada stasiun 2 (Putusan Marihot) ditemukan paling banyak jumlah ikan 151 ekor, diiukuti stasin 3 (Lubuk Kapas) 111 ekor, stasiun 3 (Muara Bato) 71 ekor dan Stasiun 4 ( Lubuk Bato ) 42 ekor. Jumlah spesies setiap stasiun 1 (8 spesies), Stasiun 2 (16 spesies), (29 spesies), stasiun 4( 18 spesies).
5W2H+M: A Broad Gamification Design Process But Focused on Motivation
Authors: Guebarra Conejo Gabriel , Gasparini Isabela , Da Silva Hounsell Marcelo 
Published: February 2020

Gamification has been increasingly implemented in systems to motivate users. To assist designers in the gamification process there are several frameworks, some of them address motivation in gamification superficially while others focus on motivation and are not broad enough. This work presents the 5W2H+M framework and its use to redesign an already gamified system. Game elements were implemented to motivate users to increase the frequency and quantity of responses; longevity of use; feeling of accompaniment, and; feeling of belonging on the users. An evaluation was conducted with a specialist and showed that the frequency, amount of questions and feeling of belonging improved. However, the longevity and accompaniment can be further addressed.
Mineração de dados auxiliando na descoberta das causas da evasão escolar: Um Mapeamento Sistemático da Literatura
Authors: Torres Marques Leonardo , Félix De Castro Angélica , Torres Marques Bruno , Carvalho Pereira Silva Jesaias , Gabriel Gadelha Queiroz Paulo 
Published: February 2020

Este trabalho apresenta um Mapeamento Sistemático da Literatura sobre evasão escolar, em que se buscou identificar tecnologias de mineração de dados e fatores indutores para evasão escolar, que vem sendo exploradas para desvendar as possíveis causas da evasão escolar. As buscas foram realizadas em quatro bases de dados científicas, com o objetivo de responder a seguinte questão de pesquisa: “Quais ferramentas, técnicas e fatores indutores vem sendo utilizados para desvendar possíveis causas da evasão escolar?”. Observou-se que a ferramenta Weka é a mais utilizada para auxiliar a desvendar as causas da evasão escolar. Entre as técnicas, destaca-se a utilização da classificação. Por fim, o mapeamento identificou que os principais trabalhos da área se concentram em estudar fatores relacionados às características individuais do aluno.
Desenvolvimento e Avaliação de um Aplicativo para Apoio ao Ensino de Psicopatologia
Authors: Pinho Feijó Lorena , Marçal de Barros Filho Edgar , Brunno Cunha Ferreira Erlane , Lustosa Augusto Kristopherson 
Published: February 2020

As metodologias de ensino têm apresentado mudanças expressivas no decorrer do século XXI. Este estudo avaliou o impacto de um aplicativo contendo vídeos simulados de psicopatologia. Realizou-se um estudo caso-controle composto por acadêmicos de Medicina. Na avaliação comparativa, utilizou-se uma prova descritiva, além do System Usability Scale (SUS). A amostra era composta por 16 alunos do grupo caso, com acesso ao aplicativo, e 82 pessoas do grupo intervenção. O grupo caso obteve escore médio de 4,7, frente à nota média de 3,2 do grupo controle (p=0,00017). Os resultados dos dados avaliados pela escala SUS demonstram uma boa avaliação de usabilidade. Assim, a utilização do aplicativo apresentou repercussões positivas para o aprendizado, sendo um instrumento útil e de boa usabilidade a ser acrescentado às demais metodologias de ensino.
O desenvolvimento de um e-book para identificar fake news: o bibliotecário como mediador na criação de critérios de avaliação da informação
Authors: Heller Bruna , Rejane Pardo Maurell Joice 
Published: February 2020

O artigo descreve o projeto de ação de um curso de especialização EAD latosensu em TIC, da Universidade Aberta do Brasil – UAB. Foi realizado em uma escola particular em Estância Velha-RS. Teve por objetivo desenvolver um e-book com critérios de avaliação para checagem de informação, visando um trabalho em conjunto de uma bibliotecária com alunos de 1º ano do Ensino Médio. A tecnologia digital escolhida foi o livro digital, elaborado na ferramenta Canva. Seguindo a metodologia educativa Ensino por Projetos, o projeto de ação foi de caráter qualitativo e descritivo, com aplicação de questionários. Após a realização das atividades, analisou-se questionários, além de considerar relatos, e observou-se apropriação em relação à tecnologia digital, à ferramenta e à importância de checar a informação antes de disseminá-la. Assim, teve-se uma ação interdisciplinar, proporcionando aos alunos o conhecimento de uma tecnologia digital antes desconhecida, além da noção de um olhar mais crítico para a informação.
Práticas pedagógicas inovadoras: o uso do podcast na perspectiva da sala de aula invertida
Authors: Smaniotto Barin Claudia , Saidelles Tiago , Machado Ellensohn Ricardo , Maria Araújo Santos Leila 
Published: February 2020

Este artigo descreve o relato de uma experiência de uso do Podcast como elemento inovador e produtor de conhecimento, numa perspectiva de sala de aula invertida. Metodologicamente o trabalho apoia-se na metodologia da Pesquisa Baseada em Design, tendo como público alvo 50 estudantes matriculados na Disciplina de Química Agronomia. Como instrumentos de coleta de dados foram utilizadas a rede social Facebook, bem como a atividade de estudo proposta na rede e uma enquete, disponibilizada a posteriori. Os resultados obtidos apontam para a flexibilidade e a potencialidade do Podcast no âmbito educacional, possibilitando engajar o estudante no processo de aprendizagem, por meio da produção de conteúdos.
Tecnologias digitais e formação de professores: Percepções e Relatos de Experiências de Alunos de um Curso de Especialização em Informática na Educação
Authors: Gardenia Lima Martins Mendes Ana , Batista Bottentuit Junior João 
Published: February 2020

Este estudo apresenta a inclusão de recursos e metodologias possibilitadas pelas tecnologias digitais por meio das práticas dos alunos de um curso de formação continuada, além disto, utilizou-se das suas próprias percepções sobre o curso ofertado na modalidade a distância. Trata-se de um estudo de caso exploratório - descritivo qualiquantitativo, realizado com 70 alunos do curso de Especialização em Informática na Educação do Instituto Federal do Maranhão. Os dados da pesquisa foram obtidos através de questionários elaborados no Google Forms, e os resultados demonstram que o curso apresenta-se como um importante meio para auxiliar seus alunos, enquanto professores, a integrar as tecnologias digitais em suas salas de aula. E, por ser na modalidade a distância, colabora com ferramentas e metodologias ao inserir seus próprios alunos na educação virtual.
Promovendo o desenvolvimento linguístico e o raciocínio lógico em práticas de letramento com uso de recursos tecnológicos
Authors: Ricardo dos Santos Paulo , Nice Ferrari Barbosa Débora , Rosana da Silva Carla , Luís Victória Barbosa Jorge 
Published: February 2020

Este artigo apresenta práticas pedagógicas com uso de dispositivos móveis tablets no ensino-aprendizagem de crianças e adolescentes atendidos por uma instituição de apoio ao tratamento oncológico. As práticas focaram no letramento dos sujeitos sob a perspectiva da leitura, escrita e raciocínio lógico, desenvolvidas com uso de aplicativos e jogos diversos. A metodologia de pesquisa utilizada foi a pesquisaação. Em 2017, as oficinas trabalharam gêneros textuais em práticas sobre sustentabilidade e em 2018 trabalhou-se com um roteiro de leitura sobre o livro “O menino que aprendeu a ver”, de Ruth Rocha. Os resultados demonstram que práticas com tecnologia favorecem os processos de letramento e raciocínio lógico, além de motivarem e contribuírem para a aprendizagem dos sujeitos.
Imagination and Ethnography.
Authors: SIDERI ELENI 
Published: February 2020

Abstract: In this paper, I will explore the use of fiction films as a teaching methods in classes of social anthropology with regional interest. I will compare the use of different films from the Black Sea region as way to 1. familiarise my students with the historical dis/continuities and presuppositions which contribute to the formation of the ‘region’, 2.bring them in contact with the methods of doing and writing ethnography. For this undertake, I am going to use four films, two from Georgia and two from the eastern shores of the Black Sea (Bulgaria and Romania). The discussion proposes a method of teaching through fiction films which traces the interlinks between imagination and representation.
Keywords: stereotypes, area studies, the Caucasus, the Black Sea, Georgia, Bulgaria, Romania, violence, corruption
Odd Harmonious Labeling on Edge Amalgamation from Double Quadrilateral Graphs
Authors: Firmansah Fery , Tasari Tasari 
Published: February 2020

A graph that has odd harmonious labeling properties is called an odd harmonious graph. The purpose of this research is to obtain a new class graphs construction which is a family of odd harmonious graphs. The research method used consisted of several stages, namely research preparation, research investigation and verifivation of research results. The results of this study, we will give a line amalgamation construction of n double quadrilateral graphs DQ, denoted by *DQ(n) with n>= 1 and graph obtained by connecting between two graphs *DQ(n) with line graph L2, denoted by *(DQ(n),L2,DQ(n)). It has further been proven that *DQ(n) and *(DQ(n),L2,DQ(n)) have odd harmonious labeling properties, such that all of them are odd harmonious graphs.
The Production and Characterization of Activated Carbon Electrodes from Pineapple Leaf Fibers for Supercapacitor Application
Authors: Agustino Agustino , Farma Rakhmawati , Taer Erman 
Published: February 2020

Elektroda karbon aktif berbasis serat daun nanas (SDN) telah berhasil diproduksi dengan proses tiga langkah berikut ini, yaitu: (i) aktivasi kimia, (ii) karbonisasi, dan (iii) aktivasi fisika. Aktivasi kimia dilakukan dengan menggunakan agen pengaktif KOH dengan konsetrasi 0,3 M. Karbonisasi dilakukan dalam lingkungan gas N2 pada temperatur 600oC dan diikuti oleh aktivasi fisika pada temperatur 850oC menggunakan gas CO2 selama 2,5 jam. Luas permukaan spesifik elektroda 512,211 m2×g-1 dengan volume total pori sebesar 0,093 cm3×g–1, dan jari-jari pori rata-rata 1,199 nm. Morfologi permukaan elektroda karbon aktif menunjukkan adanya serat karbon dengan diameter serat dalam kisaran 101 - 185 nm dan memliki kandungan karbon dengan massa atomik sebesar 84,33%. Elektroda karbon aktif memiliki struktur amorf, yang ditunjukkan oleh dua puncak difraksi yang lebar pada sudut hamburan 24,64 dan 43,77o yang bersesuaian dengan bidang (002) dan (100). Kapasitansi spesifik, energi spesifik dan daya spesifik sel superkapasitor yang dihasilkan masing-masing sebesar 110 F×g-1, 15,28 Wh×kg-1 dan 36,69 W×kg-1. Pineapple leaf fiber (PALF) based activated carbon electrode has been successfully produced using three-step process, i.e. (i) chemical activation, (ii) carbonization, and (iii) physical activation. The chemical activation was carried out using KOH activating agent with a concentration of 0.3 M. The carbonization process is conducted out in N2 gas environment at 600oC and followed by physical activation at a temperature of 850oC by using CO2 gas for 2.5 h. The specific surface area of the electrode is 512.211 m2×g-1 with a total pore volume of 0.093 cm3×g-1, and average pore radius of 1.199 nm. The surface morphology of the electrode shown the carbon fibers with diameter in the range of 101 - 185 nm and carbon content with 84.33% of atomic mass. The activated carbon electrode has an amorphous structure, which is shown by two wide diffraction peaks at scattering angles of 24.64 and 43.77o which correspond to the plane (002) and (100), respectively. The specific capacitance, energy and power of the electrode are 110 F×g-1, 15.28 Wh×kg-1 and 36.69 W×kg-1, respectively.Keywords: Serat daun nanas, Kalium hidroksida, Elektroda karbon aktif, Kapasitansi spesifik, Superkapasitor