bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutics and medical emergencies
Authors: Longridge Nicholas , Clarke Pete , Aftab Raheel , Ali Tariq 
Published: November 2020

Abstract
Firstly, do no harm. This is held as the first law of clinical practice when considering any intervention to improve the health of our patients. This may at times be a difficult proposition, especially when the approach to treating a condition is fraught with risks and can carry the danger of adverse and unwanted side effects. Prescribing therapeutics is the time perhaps when this maxim should be most at the forefront of a clinician’s mind, as therapeutic interven­tions may not cause any immediately discernible danger or harm in the same way as operative interventions. It is therefore important for the prescriber to understand the relevant pharmacodynamics (the effects of the agent on the body) and pharmacokinetics (the effects of the body on the agent). To add a further layer of complexity, the reader should understand that pharmacological sciences are possibly the fastest evolving part of medicine. It would be a fair bet to say that, within the course of the reader’s undergraduate education, entire new classes of therapeutics will have emerged and established perceptions of other agents would have significantly changed. Practically speaking, this does not mean that it is necessary to mem­orize the nuances of all therapeutic agents (although you should have a good grasp of those you prescribe regularly); rather it is more important that a clinician understands how to recognize potential dangers and then be resourceful enough to mitigate against them, given the best know­ledge available at the time. Access to an up- to-date formulary and the will to use it are the surest way to navigate any prescribing pitfalls. ‘We don’t rise to the occasion, we fall to the most basic level of our training’. Thankfully, medical emergencies occur infrequently in the general practice setting. It is the rarity of such events that often leads to anxieties when dealing with them. This reaction is amplified by the caregiver’s nat­ural instinct to do something immediately, but often not knowing exactly what to do because the diagnosis is not immediately clear. The ABCDE approach, as advocated by the Resuscitation Council, is a safe and methodical way to approach any emergency. ABCDE is not only a hierarchy of importance for systems critical to life, but it also acts as an aide- memoire to undertake examinations and interventions when necessary. Most importantly, it buys time whilst the diagnosis is found or declares itself, without adversely affecting the outcome by inaction. Key topics include: ● Common drugs for common medical conditions ● Drug interactions ● Oral side effects of medications ● Basic life support ● Medical emergencies in dentistry (including the Resuscitation Council UK guidelines) ● ABCDE approach.
Burns Night: Combustion
Authors: Atkins Peter 
Published: November 2020

Abstract
Burning, more formally combustion, denotes burning in oxygen and more commonly in air (which is 20 per cent oxygen). Combustion is a special case of a more general term, ‘oxidation’, which originally meant reaction with oxygen, not necessarily accompanied by a flame. The rusting of iron is also an oxidation, but we don’t normally think of it as a combustion because no flame is involved. Oxidation now has a much broader meaning than reaction with oxygen, as I shall unfold in Reaction 5. For now, I shall stick to combustion itself. To achieve combustion, we take a fuel, which might be the methane, CH4, 1, of natural gas or one of the heavier hydrocarbons, such as octane, C8H18, 2, that we use in internal combustion engines, mix it with air, and ignite it. The outcome of the complete combustion of any hydro-carbon is carbon dioxide and water but incomplete combustion can result in carbon monoxide and various fragments of the original hydrocarbon molecule. All combustions are ‘exothermic’, meaning that they release a lot of energy as heat into the surroundings. We use that energy for warmth or for driving machinery. Another example of an exothermic combustion is provided by the metal magnesium, which gives an intense white light as well as heat when it burns in air. A part of the vigour of this reaction is due to the fact that magnesium reacts not only with oxygen but also with nitrogen, the major component of air. You should be getting a glimpse of the broader significance of the term ‘oxidation’ in the sense that the reaction need not involve oxygen; in magnesium’s case, nitrogen can replace oxygen in the reaction. Magnesium foil was used in old-fashioned photographic flashes and in fireworks. The latter now mostly use finely powdered aluminium, which is much cheaper than magnesium and reacts in much the same way. In what follows you could easily replace aluminium with magnesium if you want to think fireworks. For the whole of the following discussion you need to be familiar with oxygen, O2, 3, a peculiar molecule in several respects.
Electric Occurrence: Electrolysis
Authors: Atkins Peter 
Published: November 2020

Abstract
Electrolysis makes use of electric currents, a stream of electrons, to bring about chemical change. It puts electricity to work by using it to break or form bonds by forcing electrons on to molecules or sucking electrons out of them. Electrolysis is an application of the redox processes I described in Reaction 5, where I showed that reduction is the gain of electrons and that oxidation is their loss. All that happens in electrolysis is the use of an external supply of electrons from a battery or other direct-current (DC) source to push them on to a species and so bring about its reduction, or the use of the electron-sucking power of a battery to remove them from a species to bring about its oxidation. Electrolysis, in other words, is electrically driven reduction and oxidation. In fact, the process is rather broader than just forcing species to accept or give up electrons because, as I have hinted, molecules might respond to the change in their number of electrons by discarding or rearranging atoms. For instance, when water is electrolysed, the H–O bonds of the H2O molecules are broken and hydrogen and oxygen gases are formed. When an electric current is passed through molten common salt (sodium chloride, NaCl), metallic sodium and gaseous chlorine, Cl2, are formed. Electrolysis is a major technology in the chemical industry, for among other applications it is used to make chlorine, to purify copper, and to extract aluminium. To bring about electrolysis, two metal or graphite rods, the ‘electrodes’, are inserted into the molten substance or solution and connected to a DC electrical supply. The electrons that form the electric current enter the substance through one electrode (the ‘cathode’) and leave it through the other electrode (the ‘anode’). A molecule or ion close to the cathode is forced to collect one or more electrons from that electrode and be reduced. A molecule or ion close to the anode is forced to release them to that electrode and thereby become oxidized. A reasonably simple first example is the purification of copper.
The Generation Game: Electrochemistry
Authors: Atkins Peter 
Published: November 2020

Abstract
You already know, if you have read Reaction 6, that an electric current is a stream of electrons. If you have also read the section on redox reactions (Reaction 5), which you should, in preparation for this account, then you will also know that in a redox reaction electrons are transferred from one species to another. Although it is now far too late, had you had that information 150 or so years ago, then you might have realized that if those species were at the opposite ends of a piece of wire, the transfer of electrons would then take place in the form of an electric current travelling along the wire and you would have invented the electric battery. All the batteries that are used to generate electricity and drive portable electrical and electronic equipment, from torches, drills, phones, music players, laptops, through to electric vehicles, are driven by this kind of chemically produced flow of electrons. One of the earliest devices for producing a steady electric current was the ‘Daniell cell’, which was invented in 1836 by John Daniell (1790–1845) of King’s College, London in response to the demand in the nineteenth century of the then emerging technology of telecommunication for a steady, cheap source of electricity. I have already touched on the underlying reaction when I explained what happens when a piece of zinc, Zn, is dropped into a solution of copper sulfate (Reaction 5), and this section builds on that account. In that reaction copper is deposited on the zinc and the copper sulfate solution gradually loses its colour as blue Cu2+ ions are replaced by colourless Zn2+ ions. As this reaction takes place, electrons hop from the zinc metal onto Cu2+ ions nearby in the solution. If we were to stand there watching, we would see electrons snapping across from the zinc to the Cu2+ ions wherever the latter came within striking distance of the zinc surface. There would be electron transfer, but no net current of electricity. Daniell did what I outlined in the opening paragraph: he separated the zinc metal and copper ions, so that electrons released by zinc had to travel through an external wire to get to the Cu2+ ions.
Neck lumps
Authors: Robinson Max , Hunter Keith , Pemberton Michael , Sloan Philip 
Published: November 2020

Abstract
Whilst dental healthcare professionals naturally focus on assessment of the teeth and the supporting tissues, they also have an important role in assessing the whole oro-facial complex and the neck. Assessment of the neck is particularly important, not least, because it contains the regional lymph nodes that are involved in immune surveillance of the head and neck region. The neck also contains the major salivary glands: the sub­mandibular gland and the tail of the parotid gland. Mid-line structures include the hyoid bone, larynx, and trachea, along with the thyroid gland and parathyroid glands. The assessment of these anatomical structures should form part of the routine clinical examination. The dis­covery of an abnormality in the neck, which may not have been noticed by the patient, may expedite the diagnosis of significant disease and facilitate a timely intervention. A through understanding of the anatomy of the neck is essential and informs the clinical examination. It is also important to understand the concept of the anatomical levels that map out the lymph node groups of the neck (Chapter 1; Fig. 1.2). Accurate assessment of the neck is usually best achieved by a combination of visual inspection and palpation, with the patient in a slightly reclined position, the clinician standing behind the patient. Any lumps, e.g. enlarged lymph nodes, are described by anatomical site, size, consistency (cystic, soft, rubbery, hard), whether the lump is mobile or fixed to the underlying tissue, and if palpation elic­its pain or discomfort. The combination of these parameters will help to formulate the differential diagnosis; for example, an isolated hard lump that is fixed to underlying structures is likely to represent meta­static cancer, whereas, bilateral soft lumps that are mobile and painful to palpation are likely to represent lymphadenitis as a consequence of systemic infection. Ultrasound examination can be used to ascertain important informa­tion about a neck lump such as the site (precise anatomical location, superficial or deep), size, consistency (solid or cystic), and multi-focality. Doppler settings can help to establish the vascularity of a lesion and its proximity to major vessels.
The Political Opposition in Japan
Authors: Scheiner Ethan , Thies Michael F. 
Published: November 2020

Abstract
Japan’s Liberal Democratic Party has controlled the country’s government for most of its existence since coming to power in 1955. Put simply, opposition parties in Japan have failed at an alarming rate for more than half a century. This chapter examines the changing patterns and causes of this opposition party failure over time. It highlights three distinct periods: (1) opposition as protest (1955–1989), (2) opposition as alternative government (1989–2012), and (3) opposition as irrelevance (2012–present). The chapter suggests that until midway through the second period, core structural conditions created massive disadvantages for the opposition, thus harming its ability to take down the LDP. However, significant changes altered these conditions and helped the opposition gain control of the government in 2009. Surprisingly, just a few years later, for reasons that were very different from before, the opposition returned to a state of near irrelevance.
Behavioral Political Science and Voter Turnout
Authors: Gerber Alan S. , Tucker Patrick D. 
Published: November 2020

Abstract
In recent decades, political scientists have placed greater emphasis on research designs that are able to measure causal effects credibly. The discipline has also participated in a social science–wide trend toward greater reliance on psychological and sociological theories to explain behavior. Both of these trends have been readily integrated into voter mobilization field experiments. This chapter reviews studies that employ field experimental designs that test the implications of psychological theories about political participation. It also reviews the use of field experiments to test psychological theories originally developed to explain behaviors outside of voting and applied and tested in the context of voting through mobilization messages. Finally, the chapter reflects on the limitations and future directions of behavioral political science as it relates to voter mobilization field experiments and political participation.
Sociological Research Ethics
Authors: Fozdar Farida , Israel Mark 
Published: November 2020

Abstract
Sociology has been at the forefront of scholarly debate about how to engage in social research ethically. This chapter considers sociology’s contribution to some of the key contemporary debates in this area. It begins with an outline of philosophical approaches to the ethics of undertaking social research, considering how these have been applied in sociological research. It also engages with the question of ethics governance models. The chapter then focuses on five established and emerging areas of ethical debate: the nature and formalization of consent; the use of new technologies and online data; the complexities of data sharing; the growing impact of insights from intercultural and indigenous research; and issues in autoethnography. It concludes with a question about the wider implications of sociological research as a social governance strategy.
The Maghreb al-Aqsa
Authors: Fili Abdallah 
Published: November 2020

AbstractIslamic archaeology in Morocco has its roots in the colonial period and developed in concert with architectural and urban studies of the imperial cities of Fes, Marrakech, and Meknes. For many years, it remained the poor relation to classical archaeology, and it was only in the 1970s and 1980s that systematic excavations began at Islamic sites. Since then, there has been a significant rise in the number of projects and amount of evidence available for urban and rural sites, particularly between the 8th and 14th centuries, though many challenges remain in terms of funding, training, finds analysis, and the use of new scientific technologies. This chapter charts the development of Islamic archaeology and lays out the key developments in urban and rural archaeology and the study of material culture in Morocco.
Community Archaeology in the Islamic World
Authors: LaBianca Øystein S. , Ronza Maria Elena , Harris Noël 
Published: November 2020

AbstractCommunity archaeology, or the notion that local officials, school teachers, community elders, workmen, and other community members might be recruited as partners in helping to preserve, protect, interpret, and present archaeological sites, is at best a nascent one in Islamic archaeology. This chapter provides a brief background to the concept and practice of community archaeology with special reference to its standing as an academic subspecialty within Islamic archaeology and its on-the-ground practice in countries with predominantly Muslim populations. The contribution of various international and professional organizations to the development of community archaeology in Islamic countries is assayed and specific projects are highlighted as examples of the kind of work that is being done in different countries. The chapter concludes by singling out the country of Jordan as being in the vanguard of a community archaeology revolution in the Islamic lands, including lessons learned in that country about best practices for implementing community archaeology projects.
Is There an “Islamic” Practice for the Preservation of Cultural Heritage?
Authors: Rico Trinidad 
Published: November 2020

AbstractThis discussion features an ongoing conversation that seeks to reveal the way that preservation practices arise from or react to uniquely “Islamic” articulations of material and immaterial cultural traditions. Although the aim of this debate is to further ethical cultural heritage preservation practices, it reveals a tension between two intellectual debates within critical heritage studies: on the one hand, a concern for the study, articulation, and stewardship of alternative heritage preservation approaches and, on the other hand, a concern with a tendency in heritage preservation to Orientalize “non-Western” heritage preservation practices as forcefully distinct from long-established “Western” practices.
Southern Syria
Authors: Walker Bethany J. 
Published: November 2020

AbstractTraditionally associated with the “Holy Land” and the target of early scientific investigations, southern Syria is one of the most intensively studied regions by archaeologists. Islamic archaeology has very old roots here, and many of the debates that have driven development of the field arose first in this region. This chapter, focusing primarily on Palestine and the Transjordan, evaluates the contributions to the field by archaeologists working there and critiques recent fieldwork as it informs such highly debated topics as Islamization, the collapse of the Late Antique polis, the militarization of frontiers, and rural resilience in times of political chaos. A special emphasis is placed on environmental and landscape research that has been opening new windows on rural society and the later historical periods.
Arabia and the Gulf
Authors: Petersen Andrew 
Published: November 2020

AbstractThis chapter introduces the main ways in which archaeology has been used to investigate Arabia’s past during the Islamic era. While the potential for archaeology within the peninsula cannot be overstated, logistical obstacles and political difficulties have made field research difficult, with the result that it has lagged behind that of other areas in the Middle East. However, recent initiatives in most of the states within the Arabian Peninsula have meant that this is now one of the leading areas for archaeological research into Islamic society and culture. Although the chapter mentions some major recent archaeological projects, the aim is to highlight current trajectories of research rather than provide an exhaustive list of excavation and survey sites. Particular attention has been paid to settlement types, partly to counter ideas that the region was primarily inhabited by Bedouin nomads. The chapter emphasizes different regional traditions to reflect the geographical diversity of Arabia and its connections with other regions. The maritime cultures of the Gulf, the Red Sea, and the Indian Ocean are particularly important in this respect and have meant that Arabia is much less isolated than its often inhospitable interior would suggest.
Transcriptomics and metatranscriptomics in zooplankton: wave of the future?
Authors: Lenz Petra H , Lieberman Brandon , Cieslak Matthew C , Roncalli Vittoria , Hartline Daniel K 
Published: November 2020

Abstract
Molecular tools have changed the understanding of zooplankton biodiversity, speciation, adaptation, population genetics and global patterns of connectivity. However, the molecular resources needed to capitalize on these advances continue to be limited in comparison with those available for other eukaryotic plankton. This deficiency could be addressed through an Ocean Zooplankton Open ‘Omics Project (Ocean ZOOP) that would generate de novo assembled transcriptomes for hundreds of metazoan plankton species. A collection of comparable reference transcriptomes would generate a new framework for ecological and physiological studies. Defining species niches, identifying optimal habitats, assessing adaptive capacity and predicting changes in phenology are just a few examples of how such a resource could transform studies on zooplankton ecology.
Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice
Authors: Mizushima Ichiro , Yamano Takahiro , Kawahara Hiroyuki , Hibino Shinya , Nishioka Ryo , Zoshima Takeshi , Hara Satoshi , Ito Kiyoaki , Fujii Hiroshi , Nomura Hideki , Kawano Mitsuhiro 
Published: November 2020

Abstract

Objectives
The 2019 ACR/EULAR classification criteria for IgG4-related disease (IgG4-RD) have exclusion criteria including positive disease-specific autoantibodies, and these have been documented to have a high specificity. This study aimed to further validate these criteria as well as identify characteristics of patients showing false-negative results.

Methods
We retrospectively analysed 162 IgG4-RD patients and 130 mimickers. The sensitivity, specificity and fulfilment rates for each criterion were calculated, and intergroup comparisons were performed to characterize the false-negative cases.

Results
Both the IgG4-RD patients and mimickers were aged ≥65 years with male predominance. The final diagnoses of mimickers were mainly malignancy, vasculitis, sarcoidosis and aneurysm. The classification criteria had a sensitivity of 72.8% and specificity of 100%. Of the 44 false-negative cases, one did not fulfil the entry criteria, 20 fulfilled one exclusion criterion and 27 did not achieve sufficient inclusion criteria scores. The false-negative cases had fewer affected organs, lower serum IgG4 levels, and were less likely to have received biopsies than the true-positive cases. Notably, positive disease-specific autoantibodies were the most common exclusion criterion fulfilled in 18 patients, only two of whom were diagnosed with a specific autoimmune disease complicated by IgG4-RD. In addition, compared with the true-positive cases, the 18 had comparable serum IgG4 levels, number of affected organs, and histopathology and immunostaining scores despite higher serum IgG and CRP levels.

Conclusions
The ACR/EULAR classification criteria for IgG4-RD have an excellent diagnostic specificity in daily clinical practice. Positive disease-specific autoantibodies may have limited clinical significance for the diagnosis of IgG4-RD.