bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Dose and Low Dose Oxytocin Regimens as Determinants of Successful Labor Induction: A multicenter comparative study
Authors: TESEMMA MELESE GEZAHEGN , Sori Demisew Amenu , Gemeda Desta Hiko 
Published: April 2020

Abstract

Background: Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of labor induction.Methods: Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia prospectively from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance. Result: The mean “Induction to delivery time” was 5.9 hours and 6.3 hours for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of < 4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction. Conclusions: In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction. We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction.
Comparison of the clinical efficacy of the Wiltse paraspinal approach and O-arm navigation for the treatment of thoracolumbar fractures
Authors: Lu Yingjie , Zhu Tianfeng , Shen Xu , Fang Yuepeng , Lu Dongdong , Zhou Liyu , Zhu Xuesong , Gan Minfeng 
Published: April 2020

Abstract
Background: To evaluate the clinical efficacy of the Wiltse paraspinal approach and percutaneous pedicle screw placement under O-arm navigation for the treatment of thoracolumbar fracture.Methods: We enrolled a total of 54 patients with neurologically intact thoracolumbar fracture who received minimally invasive treatment. Among these, 28 patients were treated with pedicle screw fixation through the Wiltse paraspinal approach (WPSF), and another 26 were received percutaneous pedicle screw fixation under O-arm navigation (OPSF). Statistical methods were used to perform a detailed comparison of clinical outcomes, radiologic findings and complications between the two groups obtained preoperatively, postoperatively and at last follow-up.Results: There were no significant differences between the two groups in terms of the intraoperative bleeding, length of incision, postoperative hospitalization durations or accuracy rate of pedicle screw placement (p>0.05). Visual analog scale (VAS) scores, Oswestry disability in­dex (ODI) scores, local Cobb angle (LCA), vertebral wedge angle (VWA) and R value were notably improved after surgery, though no clear discrepancy between the groups at each time point (p>0.05). However, the OPSF group had a longer operation time and greater surgical expenditure than the WPSF group (p<0.05).Conclusions: Both WPSF and OPSF were safe and effective for the treatment of thoracolumbar fracture. Although the two groups showed favorable clinical and radiologic outcomes through the final follow-up, we recommended the minimally invasive WPSF given its lower duration of surgery and medical costs. A randomized controlled study of high-quality and with a larger sample size is required to comfirm our findings in the future.
The neutrophil enzyme myeloperoxidase modulates neuronal response after subarachnoid hemorrhage, a sterile injury model
Authors: Coulibaly Aminata P. , Pezuk Pinar , Varghese Paul , Gartman William , Triebwasser Danielle , Kulas Joshua A. , Liu Lei , Syed Mariam , Tvrdik Petr , Ferris Heather A , Provencio Jose Javier 
Published: April 2020

Abstract
Background: Aneurysmal subarachnoid hemorrhage (SAH) is associated with the development of delayed cognitive deficits. Neutrophil infiltration into the central nervous system (CNS) is linked to the development of these deficits after SAH. It is however unclear how neutrophil activity influences CNS function in SAH. As such, the present project aims to elucidate neutrophil factors and mechanisms mediating CNS injury and cognitive deficits after SAH. Methods: Using a murine model of SAH and mice deficient in neutrophil effector functions, we determined which neutrophil effector function is critical to the development of deficits after SAH. Also, in vitro techniques were used to elucidate how neutrophils affect cellular function of neurons and glia after SAH. Results: Our results show that following SAH, neutrophils infiltrate the meninges, and not the brain parenchyma. Mice lacking functional myeloperoxidase (MPO KO), a neutrophil enzyme, lack both the meningeal neutrophil infiltration and the cognitive deficits associated with SAH. The re-introduction of biologically active MPO, and its substrate hydrogen peroxide, to the cerebrospinal fluid of MPO KO mice at the time of hemorrhage restores the spatial memory deficit observed after SAH. Furthermore, in culture, MPO affects the function of both primary neurons and astrocytes, though not microglia. Neurons exposed to MPO and its substrate show decreased calcium activity at baseline and after stimulation with potassium chloride. In addition, MPO and its substrate lead to significant astrocyte loss in culture, phenocopying a result observed in the brain after SAH. Conclusions: These results implicate MPO as a mediator of neuronal dysfunction in SAH through their effect on both neurons and astrocytes. Finally, these results show that, in SAH, the activity of innate immune cells in the meninges can modulate the activity and function of the underlying brain tissue.
Health Risk Behavior And Associated Factors Among Myanmar Migrant Workers In Samut Sakhon Province, Thailand
Authors: Paratthakonkun Chirawat , Soonthornworasiri Ngamphol , Maneekan Pannamas , Toraksa Kanittha , Zaw Aung Phone , Thu Sai Wai Yan Myint , Arthan Dumrongkiet 
Published: April 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
MiR-142-3p could serve as a potential biomarker for individualized treatment of solitary and multiple leiomyomas
Authors: Xue Luqi , Yang E , Li Zhengyu , Gou Jinhai , Nie Dan , Jia Jia , Feng Juntao , Yi Tao 
Published: April 2020

Abstract
Background The pathogenesis and clinical behaviors between solitary leiomyoma (SL) and multiple leiomyomas (ML) vary, which lead to the difference in management for childbearing-aged patients. Herein, we aim to find the potential miRNA biomarkers for optimizing the individualized management between SL and ML. Methods A microarray analysis was conducted to screen out the potentially dysregulated miRNAs. Target genes and signaling pathway potentially involved in UL pathogenesis were predicted by bioinformatics. The effect of miRNA was examined by Cell Counting Kit-8 proliferation assay and qRT-PCR after transfection of miRNA mimics Results The top 5 differentially expressed miRNAs, Wnt signalling pathway and its two central molecules APC and CTNNB1 were screened out according to microarray analysis and bioinformatics. MiR-142-3p was selected for further exploration. In validation of qRT-PCR, MiR-142-3p was significantly upregulated in SL, while downregulated in ML, CTNNB1 and sequencing target AXIN-2 were expressed at higher level in ML than SL. Overexpression of MiR-142-3p resulted in lower transcription level of CTNNB1 and AXIN-2, and lower cell proliferation level. Conclusions MiR-142-3p may be involved in the development of SL and ML by interacting with CTNNB1 and AXIN-2 through Wnt signaling pathway. MiR-142-3p could serve as a potential biomarker for individualized treatment between SL and ML in the future.
Evaluation of ultrafiltrated dairy by-products as fat replacers in the production of reduced fat washed curd cheese
Authors: Borges Ana Raquel , Pires Arona Figueiroa , Marnotes Natalí Garcia , Gomes David Gama , Henriques Marta Fernandes , Pereira Carlos Dias 
Published: April 2020

Abstract
In the present study different dairy by-products were used as ingredients in the production of reduced-fat (RF) washed curd cheeses. Whey, buttermilk and sheep’s second cheese whey, previously concentrated y ultrafiltration (UF), were used envisaging the improvement of texture and flavour of the RF cheeses. UF concentration, is a technique that can be easily available to small scale dairy plants, allowing for the recovery of those dairy by-products. Conventional full-fat (FF) cheeses presented more than 45% fat (d/b) while RF cheeses presented values in the range 20-30%, being in most cases classified as low-fat cheeses according to national standards. The ratio protein in dry matter/fat in dry matter was lower than 1 in FF cheeses and in the range 1.8-2.7 in RF cheeses. The paste of FF cheeses presented a more pronounced yellow colour at the 60th and 90th days of ripening, indicating that fat plays a major role regarding this parameter. The different by-products showed different performances when added to milk used in the production of cheeses. After the 60th day of ripening, FF cheeses and RF cheeses with added buttermilk presented lower values for the hardness of the paste (5.0-7.5 N) when compared to the remaining cheeses. At the end of ripening, chewiness of the paste was also significantly lower in these cheeses. RF cheeses with 5% incorporation of UF concentrated buttermilk presented the best results both concerning texture and sensory evaluation. This fact can be related to the specific composition of buttermilk, namely to its richness in phospholipids.
The prognostic value of immune infiltration signature and its potential mechanism in gastric cancer
Authors: Zeng Jie , Yu Tianyu , Li Xuan , Duan Hongxia , Xie Shuanshuan , Wang Changhui 
Published: April 2020

Abstract
The development of gastric cancer (GC) is closely associated with tumor microenvironment. Tumor infiltrating immune cells (TIICs), as a significant component of the tumor microenvironment, not only dominates the immune response of tumors, but is also valuable prognostic indicators. In our study, GC patients from GEO database and TCGA database were enrolled. The proportion of 22 kinds of TIICs were accurately evaluated by a deconvolution algorithm named CIBERSORT. The result showed TIICs component were varied in cancer tissue and adjacent tissue, besides the TIICs component had an effect on overall survival (OS). After LASSO cox regression and stepwise filter optimization analyzed, tumor tissues which were riches in M2 macrophages and activated mast cells, lack of plasma cells or activated CD4 memory T cells and neutrophils may cause a poor prognosis. Based on this result, a novel nomogram was stablished to assess the survival rate of GC patients. A survival immune risk (SIR) score model was further developed to validate the relationship between immune infiltration and pathological traits or oncogenic pathways in GC. In conclusion, this study may be contributed to finding new immunotherapy targets and providing individualize treatment strategies for GC patients.
A study on the biomass wastes' combustion process and their biochar
Authors: Hadey Chaimaa , Malika Allouch , Mohammed Alami , Fatima Boukhlifi 
Published: April 2020

Abstract
Peanut shells (PS) and sugar canes (SC) constitute an attractive and an energetic biomass source in Morocco since they are renewable, abundant and available. this work seeks to study the thermal decomposition of these biomass samples and their derived solid biofuel under oxidative atmosphere, and it also attempts to determine their kinetic and thermodynamic combustion parameters . The solid biofuel samples were produced by slow pyrolysis at a temperature of 400°C. Based on the TGA results, the biomass combustion process goes through three stages which are the evaporation of moisture, devolatilization and char formation. For the biochar, it takes two steps that corresponds to the evacuation of water and to the coal combustion. Kinetic parameters of each step are evaluated using Coats-Redfern method, and the thermodynamic parameters are calculated. The results have shown that biochar is less reactive than its original biomass, and that the biomass samples are the most reactive ones in the coal oxidation stage. We have also found that the biomass samples present a different combustion process. These results are useful for the configuration and the design of feasible systems for the conversion of this biomass into energy.
Environmental shaping of the bacterial and fungal community in infant bed dust and correlations with the airway microbiota
Authors: Gupta Shashank , Hjelmsø Mathis H. , Lehtimäki Jenni , Li Xuanji , Mortensen Martin Steen , Russel Jakob , Trivedi Urvish , Rasmussen Morten A. , Stokholm Jakob , Bisgaard Hans , Sørensen Søren Johannes 
Published: April 2020

Abstract
Background From early life children are exposed to a multitude of environmental exposures, which may be of crucial importance for a healthy development. Here, the environmental microbiota may be of particular interest as it represents the interface between environmental factors and the child. As infants in modern societies spend a considerable amount of time indoors, we hypothesize that the indoor bed dust microbiota might be an important factor for the child and for the colonization of the early airway microbiome. To explore this hypothesis, we analysed the influence of environmental exposures on 577 dust samples from children’s beds (age 6 months) together with 542 airway samples (age 3 months) from the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort. Results The bed dust and airway microbiota were both profiled with bacterial amplicon sequencing while also fungal community was profiled from bed dust. Bacterial and fungal diversity in the dust was positively correlated. We observed that bacterial bed dust microbiota was influenced by multiple environmental factors, such as type of home (house or apartment), rural or urban living environment and pets (cat and/or dog), whereas fungal bed dust microbiota was majorly influenced by the sampling season. We further observed minor associations between bed dust and airway microbiota compositions among infants, but no evidence of transfer of individual taxa between the two departments. Conclusions Our finding demonstrate that bed dust microbiota is influenced by environmental exposures and could represent an interface between environment and child.
Assessing malnutrition in pregnant women using the Dietary Diversity Score and the Mid-Upper Arm Circumference: A cross-sectional study, Zambia
Authors: Mayimbo Sebean , Haruzivishe Clara Maphosa , Kwaleyela Concepta , Bwembya Phoebe , Chirwa Ellen , Kelly Paul , Kaonga Patrick , Ngoma Catherine 
Published: April 2020

Abstract

Background One of the easiest and effective ways of predicting under nutrition is to use the Dietary Diversity Score (DDS) and the mid-upper arm circumference (MUAC). The dietary diversity score is a qualitative measure of food consumption reflecting an individual’s access to different food items and therefore is a proxy indicator of the nutritional status. The aim of the study was to assess whether the DDS and MUAC can be used to assess the nutritional status of pregnant women attending antenatal. Methods A cross-sectional survey was conducted at Chilenje level I Hospital in a township located in Lusaka city, Lusaka province. The study employed quantitative methods to collect and analyse data on the dietary patterns and if this can be used to assess the nutritional status of individuals 24 hours preceding the survey. Health facilities were selected using random sampling method and systematic sampling method was used to select a sample of 299 pregnant women. An interview schedule was used to collect data. Logistic regression was used to establish associations between DDS and MUAC. Results In this study, 44% of the women were in the lowest dietary diversity category, which indicates inadequate nutrient intake, 31% in the medium category and 24% in the high intake. Maternal weight was associated with a 0.08 cm increase in MUAC (95% CI; 0.74 – 0.93) and this was statistically significant. Marital status and age (95% CI; 0.83 – 0.93) were significantly associated with an increase in MUAC in the univariate analysis but when adjusted for other confounders this was not significant (95% CI; 0.81 – 1.00). Consumption of organ meat was associated with a 0.21cm increase in MUAC (95% CI; 0.04 - 0.97). Conclusion The study results indicated that 44% of the women had inadequate nutrient intake, indicating that the dietary diversity score can be used to predict malnutrition in pregnant women. The mid upper was negatively correlated with the 24hour dietary diversity score implying that we might not rely on this measurement to assess the nutritional status. Key words Dietary Diversity Score, Malnutrition, Mid Upper Arm Circumference, Pregnant women, Antenatal.
La competitividad de los partidos políticos en Baja California en las elecciones de 1997
Authors: Martínez Herrera Leopoldo 
Published: April 2020

En México, la transición democrática, como estrategia del cambio político, ha cobrado una alta dinamicidad; además, los partidos han tenido que someterse a la evaluación de los ciudadanos, esto último derivado de la recuperación de la autonomía de la conciencia de la sociedad. Bajo los anteriores supuestos, la competitividad politico-electoral, a la vez que es un método para medir la capacidad deofensiva y de disputa de los partidos políticos en las actuales circunstancias, es también una condición para su actuación en medio de un sistema electoral moderno, democrático, y por ello, equitarivo. Un caso ilustrativo lo constituye Baja California,que el 6 de julio de 1997. eligió a seis representantes distritales a la Cámara de Diputados de la Nación. El resultado de dicho evento se presenta en este artfculo a la luz de la medición de la competividad de los partidos que contendieron en ella a través de cinco indicadores: a) competitividad simple, b) margen de victoria delPAN respecto al PRI. c) potencia opositora. d) número de partidos y e) expansión del sistema electoral.
The Significance of Renal Function in Response to Cardiac Resynchronisation Therapy – A Piece of a Much Larger Puzzle
Authors: Dębska-Kozłowska Agnieszka , Warchoł Izabela , Książczyk Marcin , Lubiński Andrzej 
Published: April 2020

Background:
Although cardiac resynchronisation therapy (CRT) is an important player in the
treatment of patients with heart failure (HF), the proportion of CRT patients with no improvement in
either echocardiographic or clinical parameters remains consistently high and accounts for about 30%
despite meeting CRT implantation criteria. Furthermore, in patients suffering from HF, renal dysfunction
accounts for as many as 30-60%. Accordingly, CRT may improve renal function inducing a systemic
haemodynamic benefit leading to increased renal blood flow.

Objectives:
The aim of the present study was to evaluate the importance of renal function in response to
resynchronisation therapy during a 12-month follow-up period.

Materials and Methods:
The study consisted of 46 HF patients qualified for implantation of cardiac
resynchronisation therapy defibrillator (CRT-D). A CRT responder is defined as a person without
chronic HF exacerbations during observation whose physical efficiency has improved owing to the New
York Heart Association (NYHA) class improvement ≥1.

Results:
A statistically significant difference was noted between responders and non-responders regarding
creatinine level at the 3rd month (p=0.04) and, particularly, at the 12th month (p=0.02) of follow-up
(100±23 vs 139±78 μmol/l). Moreover, there was a remarkable difference between both study groups
with regard to GFR CKD-EPI (glomerular filtration rate (GFR) assessed using the Chronic Kidney Disease
Epidemiology Collaboration (CKD-EPI) formula) at the 6th (p=0.03) and 12th month (p=0.01) of
follow-up. The reference values for initial creatinine concentrations (101 μmol/l) as well as GFR CKDEPI
(63 ml/min/1.73m2) were empirically evaluated to predict favourable therapeutic CRT response.

Conclusions:
Predictive value of GFR CKD-EPI and creatinine concentration for a positive response to
CRT was found relevant.
Identification of Carcinogenic Chemicals with Network Embedding and Deep Learning Methods
Authors: Peng Xuefei , Chen Lei , Zhou Jian-Peng 
Published: April 2020

Background:
Cancer is the second leading cause of human death in the world. To date,
many factors have been confirmed to be the cause of cancer. Among them, carcinogenic chemicals
have been widely accepted as the important ones. Traditional methods for detecting carcinogenic
chemicals are of low efficiency and high cost.

Objective:
The aim of this study was to design an efficient computational method for the
identification of carcinogenic chemicals.

Methods:
A new computational model was proposed for detecting carcinogenic chemicals. As a
data-driven model, carcinogenic and non-carcinogenic chemicals were obtained from Carcinogenic
Potency Database (CPDB). These chemicals were represented by features extracted from five
chemical networks, representing five types of chemical associations, via a network embedding
method, Mashup. Obtained features were fed into a powerful deep learning method, recurrent
neural network, to build the model.

Results:
The jackknife test on such model provided the F-measure of 0.971 and AUROC of 0.971.

Conclusion:
The proposed model was quite effective and was superior to the models with
traditional machine learning algorithms, classic chemical encoding schemes or direct usage of
chemical associations.