bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Authors: Abkhooie Leila , Sarabi Mostafa M. , Kahroba Houman , Eyvazi Shirin , Montazersaheb Soheila , Tarhriz Vahideh , Hejazi Mohammad S. 
Published: November 2020

Abstract:
Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements
for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and
regulate certain aspects of physiological and pathological processes in myocardiocytes, including
cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through
different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed
the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders.
In this review, we have summarized recent findings in the field of epigenetic modulations of
myomiRs and cardiac regeneration associated with cardiac diseases.
Veno-Arterial Extracorporeal Membrane Oxygenation in the Adult: A Bridge to the State of the Art
Authors: Gennari Marco , L’Acqua Camilla , Rubino Mara , Agrifoglio Marco , Salvi Luca , Ceriani Roberto , Marenzi Giancarlo , Marana Ivana , Polvani Gianluca 
Published: November 2020

Abstract:
Despite the technological advancements in the last 40 years, conditions such as refractory
cardiogenic shock and cardiac arrest still present a very high mortality rate in real-world clinical
practice.
In this light, we have reviewed the techniques, indications, contraindications, and results of the socalled
Veno-Arterial Extracorporeal Circulatory Membrane Oxygenation (VA-ECMO) in the adult
population to evaluate the current results of this temporary cardio-pulmonary support as salvage
and/or bridge therapy in the patient suffering from refractory cardiogenic shock or cardio-circulatory
arrest.
The results are encouraging, especially in the setting of refractory cardiogenic shock and in-hospital
cardiac arrest. Among a selected population, the prompt institution of a VA-ECMO may radically
change the prognosis by sustaining vital functions while looking for the leading cause or waiting
for the reversal of the temporary cardio-respiratory negative condition.
The future directions aim to standardized and shared protocols, miniaturization of the machines,
and possibly the institution of specialized “ECMO teams” for in and the out-of-hospital institution
of the tool.
Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells
Authors: Chen Chuan , Zhao Ziyue , Dong Qian , Gao XueHui , Xu Huibin , Yang Runlei , Qin JianChun , Luo Duqiang 
Published: November 2020

Background:
Xanthones are a class of heterocyclic natural products, which are promising sources of
anti-cancer leads. Phomoxanthone B (PXB) and Phomoxanthone A(PXA)are xanthone dimers. PXA is wellstudied
as an anti-cancer agent, but PXB is not. In our study, PXB was isolated from the endophytic fungus
Phomopsis sp. By254.

Objective:
The purpose of this study was to identify the underlying anti-tumor mechanisms of PXB in breast cancer MCF7 cell line.

Methods:
Apoptosis, cell cycle, proliferation, invasion and migration assays were used to assess the antitumor activity of PXB. RNA sequencing was used to analyze the effect of PXB treatment on gene expression in MCF7 cells.

Results:
PXB showed cytotoxicity towards a variety of tumor cells, especially MCF7 cells. PXB inhibited the
migration and invasion, arrested cell cycle at G2/M phase, and induced apoptosis associated with caspase-3
activation in MCF7 cells. The detailed transcriptome analysis revealed that PXB affected several pathways
related to tumorigenesis, metabolisms, and oxidative phosphorylation in MCF7 cells. KEGG transcriptome
analysis revealed that PXB upregulated pro-survival signal pathways, such as MAPK, PI3K-AKT, and STAT3
pathways. We found that PXB also significantly upregulated the expression of IL24, DDIT3, and XAF1, which
may contribute to PXB-induced apoptosis. We further found that PXB may downregulate oxidative
phosphorylation by decreasing the expression of electron transport chain genes, especially MT-ND1, which is a
potential unfavorable prognostic marker for ER-positive breast cancer.

Conclusion:
PXB exerts strong cytotoxicity against human tumor cells and has a potential for ER-positive breast
cancer treatment.
Adaptive Frame of Universal Vehicle Course
Authors: Asemkhanuly A. , Niyazova Zh. , Karpov A. , Ustemirova R. , Kainarbekov A. 
Published: November 2020

Background:
Motor vehicles play an important role in the economies of many countries, providing efficient means of transporting goods and people. These vehicles can also have significant impacts on safety, infrastructure and the environment.

Methods:
The design of the suspension affects the vehicle's performance, in terms of the drive, damage to infrastructure, the working space of the suspension, power, and stability against overturning, stability against yaw, braking, and traction.

Results:
The article considers the types and methods of application of adaptive suspensions of modern vehicles, justifies the feasibility of their use for various vehicles, such as modern cars, tractors, etc., which allows the usage of these vehicles for traffic in different road conditions - mountainous terrains with a slope of more than 35o, steppe off-road conditions with frontal obstacles up to half the length of the wheel radius.

Conclusion:
The existing control schemes and prospects for their further development can be improved and intelligent transport systems could be introduced.
Association Between Awareness of Informal Caregivers and Falls in Elderly Patients with Uncontrolled Diabetes Mellitus
Authors: Chamnankit Tossapon , Ong-artborirak Parichat , Wangrath Jukkrit 
Published: November 2020

Background:
Elderly people with uncontrolled diabetes mellitus (DM) are at risk of falls, which can lead to injury and disability. Not much is known of informal caregivers’ awareness of falls in elderly patients with DM.

Objective:
This study aims to identify an association between caregiver’s awareness and falls in elderly patients with DM.

Methods:
A total of 136 pairs of DM patients and their respective family caregivers were recruited from a clinical service center at Chiang Mai University, Thailand. The questionnaire regarding the caregiver’s awareness of the risk of falls in elderly patients was given via a face-to-face interview. Each elderly patient was asked about their history of falls in the prior year, and the risk of falls was assessed by Time Up & Go (TUG) test. Logistic regression analysis was performed to determine association.

Results:
The mean age of the DM patients was 65.7 years. Sixty-two patients (45.6%) had fallen at least once in the prior year. The mean TUG test result was 12.67±1.83 second. Most caregivers demonstrated a high level of awareness regarding the risk of falls in elderly patients. The results of the multivariable analysis showed that three variables – balance problems, risk of falls assessed by TUG test, and scores of caregiver’s awareness of risk of falls – were significantly related to falls in the previous year among elderly patients with DM (p-value<0.05).

Conclusion:
The caregivers’ awareness of fall risk may influence fall occurrence among older adults with DM. An intervention program to improve awareness among informal caregivers should be considered for fall prevention in elderly people.
Using Genetic Algorithm for Investigating the Performance of Carbonbasalt/ Polyester Hybrids Composite Materials
Authors: Belkheir Mohammed , Doumi Bendouma , Mokaddem Allel , Boutaous Ahmed 
Published: November 2020

Background::
The composite materials are more efficient and more resistant compared
to so-called traditional materials. The application of continuous and variable forces modifies the
properties of the materials, and generates the formation of cracks which lead to the rupture of
structures.

Objective::
The objective of this work is to study the reliability and the origin of the resistance of
each fiber-matrix interface of the two hybrid composite materials studied.

Methods::
In this study, the genetic algorithm is based on Weibull’s probabilistic approach to calculate
the damage to the interface and also on the Cox model to find and initialize the different
values used in simulation model.

Results::
The results obtained by genetic modeling, have shown that the hybrid Carbon High Modulus
(HM)/Basalt/Polyester composite is the most resistant to the mechanical stresses applied
comparing with that of Carbon High Strength (HS)/Basalt/Polyester. These results were confirmed
by the level of damage to the interface found for the two materials studied and that the interface
shear damage of the hybrid Carbon HM/Basalt/Polyester composite is much lower by 13% compared
to that of Carbon HS/Basalt/Polyester.

Conclusion::
The calculations are in good agreement with the analytical results of Cox, where he
demonstrated that Young’s modulus of the fibers has an important influence on the shear strength
of the fiber/matrix interface of composite materials.
Higher-Dose Sitagliptin and the Risk of Congestive Heart Failure in Older Adults with CKD
Authors: Muanda Flory T. , Weir Matthew A. , Bathini Lavanya , Clemens Kristin K. , Perkovic Vlado , Sood Manish M. , McArthur Eric , Sontrop Jessica M. , Kim Richard B. , Garg Amit X. 
Published: November 2020

Background and objectives
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is commonly prescribed to patients with type 2 diabetes. As this drug is primarily eliminated by the kidney, a reduced dose is recommended for patients with CKD. Some evidence suggests that sitagliptin is associated with a higher risk of congestive heart failure, particularly at higher doses. We compare the 1-year risk of death or hospitalization with congestive heart failure in patients with CKD newly prescribed sitagliptin at >50 versus ≤50 mg/d.

Design, setting, participants, & measurements
This population-based cohort study included older adults (>66 years) with type 2 diabetes and an eGFR<45 ml/min per 1.73 m2 (but not receiving dialysis) who were newly prescribed sitagliptin between 2010 and 2017 in Ontario, Canada. We used inverse probability of treatment weighting on the basis of propensity scores to balance baseline characteristics. The primary composite outcome was death or hospitalization with congestive heart failure. Secondary outcomes included hospitalization with pancreatitis or hypoglycemia, all-cause hospitalization, and glycemic control. Weighted hazard ratios were obtained using Cox proportional hazards regression, and 95% confidence intervals were obtained using bootstrap variance estimators.

Results
Of 9215 patients, 6518 started sitagliptin at >50 mg/d, and 2697 started sitagliptin at ≤50 mg/d. The 1-year risk of death or hospitalization with congestive heart failure did not differ significantly between groups (79 versus 126 events per 1000 person-years; weighted hazard ratio, 0.88; 95% confidence interval, 0.67 to 1.14); hospitalization with pancreatitis (weighted hazard ratio, 0.98; 95% confidence interval, 0.32 to 3.03) and hypoglycemia (weighted hazard ratio, 1.10; 95% confidence interval, 0.64 to 1.90) also did not differ significantly between groups. Patients starting sitagliptin at >50 mg/d had lower mean glycated hemoglobin concentrations (weighted between-group difference, −0.12%; 95% confidence interval, −0.19 to −0.06) and a lower risk of all-cause hospitalization (weighted hazard ratio, 0.81; 95% confidence interval, 0.66 to 0.98).

Conclusions
The risk of death or congestive heart failure was not higher in older adults with CKD starting sitagliptin at >50 versus ≤50 mg/d.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_11_25_CJN08310520_final.mp3
Pelatihan Pembuatan Laporan Pertanggungjawaban Keuangan Kepala Sekolah dasar di Kota Administrasi Jakarta Barat
Authors: Khuluqo Ihsana El , Istaryatiningtias  
Published: November 2020

Pelatihan pembuatan laporan pertanggungjawaban keuangan kepala sekolah dasar di Kota Administrasi Jakarta Barat dilaksanakan untuk mengurangi atau bahkan menghilangkan kesalahan-kesalahan yang terjadi pada penyusunan laporan pertanggungjawaban keuangan sehingga tidak terlibat konflik dengan Badan Pemeriksa Keuangan (BPK). Pelatihan ini dilakukan dengan tujuan memberikan wawasan tentang penyusunan dan penulisan Laporan Pertanggungjawaban Keuangan yang baik merujuk pada peraturan yang berlaku. Metode yang digunakan yaitu dengan menggunakan metode kualitatif melalui pendekatan persuasif. metode ini digunakan karena dinilai tepat dalam melakukan analisis situasi dan menemukan permasalahan serta solusi dari permasalahan tersebut. Pelaksanaan Pelatihan pembuatan laporan pertanggungjawaban keuangan kepala sekolah dilaksanakan di Sekolah Dasar Meruya Utara 02 dengan diikuti oleh 12 Sekolah Dasar yang terdiri atas kepala sekolah dan juru bayar sekolah dasar negeri di kota administrasi Jakarta Barat. Hasil pelatihan ini yaitu kepala sekolah dan juru bayar sekolah mengetahui dimana letak kesalahan-kesalahan pada penyusunan laporan pertanggungjawaban keuangan sekolah terkait dengan dana Bantuan Operasional Pendidikan (BOP), dana Biaya Operasional Sekolah (BOS) dan Kartu Jakarta Pintar (KJP) serta memberi pengetahuan terkait panduan penyusunan laporan pertanggungjawaban keuangan sekolah berdasarkan aturan baku pemerintah.
Peningkatan Pemahaman Kesehatan pada Ibu hamil dalam Upaya Pencegahan COVID-19
Authors: Aritonang Juneris , Nugraeny Lolita , Sumiatik  , Siregar Ronni Naudur 
Published: November 2020

Pemerintah Indonesia menetapkan bencana non alam penyebaran COVID-19 sebagai bencana nasional dikarenakan bencana ini berdampak meningkatnya jumlah korban jiwa, ekonomi dan luasnya wilayah yang terkena bencana ini. Ibu hamil tercatat salah satu kelompok rentan resiko terinfeksi COVID-19 dikarenakan pada masa kehamilan terjadinya perubahan fisiologi yang mengakibatkan penurunan kekebalan parsial. Pada studi awal dilakukan sebelum kegiatan ditemukannya masih banyak ibu hamil ketika beraktivitas di luar rumah ttidak sesuai dengan protokol kesehatan seperti tidak memakai masker, masih berbicara dengan tetangga tanpa menjaga jarak, dan sesekali tanpak masih ikut dalam kerumunan dan tingginya tingkat kecemasan ibu hamil pada era pandemi COVID-19 ini. Kecemasan yang di tunjukkan oleh ibu hamil yang diwawancarai tersebut tidak sesuai atau berbanding terbalik dengan perilaku ibu hamil dalam kepatuhan melaksanakan protokol kesehatan kesehariannya. Sehingga dibutuhkan suatu cara yakni memberikan pendidikan kesehatan melalui penyuluhan dengan tujuan untuk peningkatan pemahaman upaya pencegahan Covid-19 pada ibu hamil, sehingga mengurangi kecemasan ibu hamil selama pandemi COVID-19. Kegiatan ini dilaksanakan di Balai Pengobatan Swasta Mariana, Deli Serdang Sumatera Utara. Dari kegiatan pengabdian masyarakat ini didapati adanya peningkatan pengetahuan dan pemahaman ibu hamil dalam upaya pencegahan COVID-19, adanya penurunan kecemasan ibu hamil selama kehamilan di era pandemi COVID-19, perlu dilakukan kegiatan serupa secara berkesinambungan hingga terjadi perubahan perilaku yang lebih baik. Perlu adanya pemantauan lebih lanjut atas perubahan perilaku setelah dilakukan penyuluhan ini.
Post-implementation Evaluation of a Digital Dictation System in a Large Health Service Using HOT-Fit Framework
Authors: Bain Christopher , Goswami Aniruddha , Lloyd Sheree , Davis Laura 
Published: November 2020

Objective: The objective of this study was to evaluate a digital dictation system (DDS) that has been implemented in a large health service. The data collected in this study was used to understand the overall uptake and performance of the system and consequently improve the quality of care delivered by the organisation.
Methods: A mixed method research design was used in this study. Clinicians and Medical Transcriptionists using the DDS across the two campuses of the health service over a period of four months, were surveyed to assess the extent to which the implementation of the DDS is fulfilling its purpose. In addition, system usage statistics, project implementation documents and user support emails were also analysed.
Results: This study utilised an existing comprehensive and validated evaluation framework, the Human, Organisation and Technology Fit (HOT-Fit) framework. Human fit: 79.55% (n=35) of Clinicians and 33.33% (n=2) of MTs reported an overall satisfaction with the DDS. Organisation fit: The document analysis revealed that the DDS selected aligned best with current organizational IT strategies and was an easy fit with existing practices. Technology fit: An overall satisfaction of 53.49% (n=23) from the Clinicians and 16.67% (n=1) from the MTs was reported on the DDS. Out of 22 issues lodged regarding the system, 77.27% (n=17) issues met the Service Level Agreement (SLA).
Conclusions: The overall findings of the study suggest that, the DDS was a good fit within the organisation in terms of Human fit and Organisation fit. In terms of Technology fit there existed some technical issues on the end-user level due to the system being new to the end users. To overcome this and facilitate the smooth functioning of the DDS, effective communication with the vendor and other relevant stakeholders was recommended so that end users i.e. the Clinicians and MTs understand the system, its functionality and their role in providing timely and high-quality information for clinical care.
Community People Preparedness and Response on Prevention and Control of COVID-19 Best Practice in Bangladesh
Authors: Das Dr.Bimal Chandra , Bhuiyan Sahedul Islam , Ullah A S M Wali , Alam Muhammad Zahangir , Mostofa Gazi Golam , Hasan Khondaker Zahirul , Sarwar Sohel , Chowdhury Reaz Uddin , Paul Joya , Haque AKM Mahbubul , Islam Mohammad Shamsal , Alauddin Mohammed 
Published: November 2020

Purpose: The major objectives of the study were to assess the knowledge, attitude & practice (KAP) towards community preparedness and response on prevention of COVID-19 among the community people.
Method: A sample survey was conducted to collect data from people admitted to a district-level tertiary hospital for the treatment of various health complications during the COVID-19 pandemic. A total of 300 randomly selected patients and their attendants were interviewed in the hospital setting.
Results: The mean knowledge score was 18.73 out of 24 and the main sources of information were TV (86.5%), radio (13%), newspaper (13%), social media (13.5%), friends/relatives (14%), formal healthcare providers (6%) and religious leaders (3%). Knowledge was significantly poor among aged people, women, less educated, and less earning. The majority of the participants (79%) suggested wearing facemasks as effective tools to prevent COVID-19 from spreading, whereas 56% mentioned maintaining physical or social distance as crucial to prevent the infection. We found strong relationship between monthly total family expenses and wearing of facemasks by gender to prevent the COVID-19 (x2= 18.405; Cramer’s V= .17, df = 8; sig; P= < .018). Similarly maintaining physical/social distance to prevent COVID-19 is also related to respondents’ economic strata (x2= 43.741; Cramer’s V= .14, df = 20; Sig; P= < .002).
Conclusions: Awareness program on COVID-19 is very important to prevent the spread of the deadly virus. Effective communication intervention with increasing treatment facilities is essential for the prevention and control of COVID-19. Government and development agencies should prioritize the COVID-19 response program with regular health care services.
Integrasi Newsroom Media Cetak Jawa Tengah (Studi Pada Harian Suara Merdeka Dan Jawa Pos Radar Semarang Menuju Konvergensi Jurnalistik)
Authors: Permatasari Vincentia Ananda Arum 
Published: November 2020

Penikmat informasi media cetak tidak lagi hanya urban native tetapi juga digital native. Untuk itu media cetak harus merubah diri menjadi media informasi yang dapat dijangkau pembacanya. Penelitian ini bertujuan memberi gambaran tentang penerapan model konvergensi media oleh media regional di Kota Semarang. Penelitian ini menggunakan pendekatan kualitatif. Data diperoleh dari wawancara semi-terstruktur terhadap wakil pemimpin redaksi Suara Merdeka dan redaktur pelaksana Jawa Pos Radar Semarang. Hasil penelitian menunjukkan bahwa konvergensi media Suara Merdeka dan Jawa Pos Radar Semarang dilakukan dalam empat area penting, yaitu Lingkup Proyek, Manajemen Ruang Berita, Praktik Jurnalistik, dan Kerja Organisasi. Berdasarkan analisis yang dilakukan, penelitian ini menyimpulkan bahwa SM dan JPRS belum menunjukkan Model Konvergensi Media yang jelas. Walapun kepemilikan media dan infrasruktur produksi telah menerapkan model full integration namun pada praktik jurnalistik dan manajemen ruang berita masih banyak menerapkan cross media dan co-ordination of isolated platforms.
ANÁLISE DOS INDÍCIOS DE CARTEL NAS REVENDEDORAS DE GASOLINA COMUM EM VIÇOSA-MG, 2016 a 2018
Authors: Jacob Kamila Gabriela , Aparecida Soares Fernandes Rosangela , Bornacki de Mattos Leonardo 
Published: November 2020

Este artigo teve como objetivo analisar a presença de indícios de conduta colusiva no segmento da gasolina comum na cidade de Viçosa-MG de 2016 a 2018. Para tanto, utilizou-se do Índice Concorrencial de Preços (ICP), das Margens de comercialização na revenda (Mgr) e da Assimetria na Transmissão de Preços (ATP), o que é uma metodologia mais atual na análise de combustíveis no Brasil. Os resultados indicaram indícios de comportamento colusivo em 2016 e 2018, mas se constatou sinais de concorrência em 2017 pelos filtros ICP e Mgr. Por meio da ATP, observou-se a presença de Assimetria do Impacto Contemporâneo (AIC) cujo choque positivo no preço da gasolina comum é repassado mais rapidamente ao consumidor pelo revendedor, ao invés dos choques negativos. Além disso, a Assimetria na Trajetória de Equilíbrio (ATAE) apontou que a velocidade de convergência depende do preço na revendedora estar abaixo do equilíbrio de longo prazo.
Applying the information acceptance model to predict purchase intention in social media
Authors: Tjongirin Richard , Gianto Matthew , Sihombing Sabrina 
Published: November 2020

E-WOM has become an essential marketing tool, as an online marketplace compete to dominate the online space. This paper assesses the relationship of e-WOM and its relationship towards purchase intention. The theoretical model based on the information acceptance model suggesting information (quality, credibility, usefulness, and adoption), needs of information and attitude towards information are the primary variables that influence purchase intention. This is a descriptive research; closed-ended questionnaires were distributed with 294 respondents with college students as the main demographic. The findings of this research show that the usefulness of information does play a significant influence toward purchase intention, but the attitude towards information does not significantly influence information usefulness. This study implies that some companies which compete in the online space should primarily focus on how useful their information is deemed by the consumers.