bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of flaxseed on physical and mental fatigue in children and adolescents with overweight/obesity: a randomised controlled trial
Authors: Gholami Zohreh , Akhlaghi Masoumeh 
Published: October 2020

AbstractAnti-inflammatory agents such as long-chain n-3 fatty acids have been recognised to improve disease-related fatigue. We hypothesised that α-linolenic acid may also benefit in reduction of fatigue in low-grade inflammation such as overweight/obesity. Seventy-two healthy children and adolescents with BMI > 25 kg/m2 were randomised to flaxseed (n 38) and puffed wheat (n 34) groups. Participants consumed isoenergetic amounts of either 20 g/d flaxseed or 25 g/d puffed wheat for 4 weeks. Fatigue, mood feelings (depression, anxiety and stress), appetite, energy intake, weight, height and waist circumference were measured. Analysis was performed based on per-protocol and intention-to-treat (ITT) approaches. Consumption of flaxseed decreased mental fatigue and caused a significant between-group difference (P < 0·001). Although no significant change in physical and total score of fatigue was observed in either group, a significant between-group difference occurred due to a more remarkable change in these parameters in the flaxseed group. General fatigue, motivation, activity and mood feelings did not change significantly between groups. Flaxseed showed less benefit than puffed wheat on anthropometric measures as it caused a smaller increase in height (0·53 (sd 0·89) v. 1·09 (sd 0·87) cm, P = 0·03) and reduction in BMI (–0·25 (sd 0·63) v. −0·67 (sd 0·56) kg/m2, P = 0·01) than puffed wheat. Appetite and waist circumference decreased in both groups, but no significant difference was observed between groups. In ITT analysis, only alteration in mental fatigue was significant. In conclusion, consumption of flaxseed may improve mental fatigue in children with overweight/obesity. However, because of smaller increase in height, it is better to hinder administration of flaxseed during periods of growth.
Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian Aboriginal and Torres Strait Islander adults
Authors: Black Lucinda J. , Dunlop Eleanor , Lucas Robyn M. , Pearson Glenn , Farrant Brad , Shepherd Carrington C. J. 
Published: October 2020

AbstractVitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentration <50 nmol/l) is recognised as a public health problem globally. The present study details the prevalence and predictors of vitamin D deficiency in a nationally representative sample (n 3250) of Australian Aboriginal and Torres Strait Islander adults aged ≥18 years. We used data from the 2012–2013 Australian Aboriginal and Torres Strait Islander Health Survey (AATSIHS). Serum 25(OH)D concentrations were measured by liquid chromatography-tandem MS. Survey-weighted logistic regression models were used to determine the independent predictors of vitamin D deficiency. Approximately 27 % of adult AATSIHS participants were vitamin D deficient. Vitamin D deficiency was more prevalent in remote areas (39 %) than in non-remote areas (23 %). Independent predictors of vitamin D deficiency included assessment during winter (men, adjusted OR (aOR) 5·7; 95 % CI 2·2, 14·6; women, aOR 2·2; 95 % CI 1·3, 3·8) and spring (men, aOR 3·3; 95 % CI 1·4, 7·5; women, aOR 2·6; 95 % CI 1·5, 4·5) compared with summer, and obesity (men, aOR 2·6; 95 % CI 1·2, 5·4; women, aOR 4·3; 95 % CI 2·8, 6·8) compared with healthy weight. Statistically significant associations were evident for current smokers (men only, aOR 2·0; 95 % CI 1·2, 3·4), remote-dwelling women (aOR 2·0; 95 % CI 1·4, 2·9) and university-educated women (aOR 2·4; 95 % CI 1·2, 4·8). Given the high prevalence of vitamin D deficiency in this population, strategies to maintain adequate vitamin D status through safe sun exposure and dietary approaches are needed.
Higher egg consumption associated with increased risk of diabetes in Chinese adults – China Health and Nutrition Survey
Authors: Wang Yue , Li Ming , Shi Zumin 
Published: October 2020

AbstractThe association between egg consumption and diabetes is inconclusive. We aimed to examine the association between long-term egg consumption and its trajectory with diabetes in Chinese adults. A total of 8545 adults aged ≥18 years old who attended the China Health and Nutrition Survey from 1991 to 2009 were included in this analysis. Egg consumption at each survey was assessed by a 3-d 24-h recall and weighed food record methods. The consumption trajectories of eggs were modelled with the latent class group approach. Diabetes was diagnosed based on fasting blood glucose in 2009. Logistic regression was used to examine the association. The mean age of the study population was 50·9 (sd 15·1) years. About 11·1 % had diabetes in 2009. Egg consumption nearly doubled in 2009 from 16 g/d in 1991. Compared with the first quartile of egg consumption (0–9·0 g/d), the adjusted OR of diabetes for the second (9·1–20·6 g/d), third (20·7–37·5 g/d) and fourth (≥37·6 g/d) quartiles were 1·29 (95 % CI 1·03, 1·62), 1·37 (95 % CI 1·09, 1·72) and 1·25 (95 % CI 1·04, 1·64), respectively (Pfor trend = 0·029). Three trajectory groups of egg consumption were identified. Compared with group 1 (30·7 %, low baseline intake and slight increase), both group 2 (62·2 %, medium baseline intake and increase) and group 3 (7·1 %, high baseline intake and decrease) were associated with an increased OR for diabetes. The results suggested that higher egg consumption was positively associated with the risk of diabetes in Chinese adults.
A predictive model for Covid-19 spread – with application to eight US states and how to end the pandemic
Authors: Khan Z. S. , Van Bussel F. , Hussain F. 
Published: October 2020

Abstract
A compartmental model is proposed to predict the coronavirus 2019 (Covid-19) spread. It considers: detected and undetected infected populations, social sequestration, release from sequestration, plus reinfection. This model, consisting of seven coupled equations, has eight coefficients which are evaluated by fitting data for eight US states that make up 43% of the US population. The evolution of Covid-19 is fairly similar among the states: variations in contact and undetected recovery rates remain below 5%; however, variations are larger in recovery rate, death rate, reinfection rate, sequestration adherence and release rate from sequestration. Projections based on the current situation indicate that Covid-19 will become endemic. If lockdowns had been kept in place, the number of deaths would most likely have been significantly lower in states that opened up. Additionally, we predict that decreasing contact rate by 10%, or increasing testing by approximately 15%, or doubling lockdown compliance (from the current ~15% to ~30%) will eradicate infections in Texas within a year. Extending our fits for all of the US states, we predict about 11 million total infections (including undetected), and 8 million cumulative confirmed cases by 1 November 2020.
In Between: Cultural Exchange and Competing Systems
Authors: SCHMIDT DÖRTE 
Published: October 2020

AbstractAfter the Second World War, cultural politics has become a central medium for international relations. Owing to the particular conditions of their development, the relations between Latin America and Europe constituted an interesting case study in which the positioning of different nations in the realm of two competing political systems and the politics of memory concerning the recent war are intertwined. This article highlights five ‘moments’ in West Germany with respect to the relationship between Europe and Latin America in the field of music: the papers of the German Federal Foreign Office, the Berlin Festival week, the Darmstadt summer courses, the DAAD Berlin Artists Program, and the Horizonte Festival in Berlin. These sources invite an observation as to how – from the perspective of cultural politics – contrasting notions of the ‘international’ have tended to ‘fade out’ after the end of Cold War polarizations, leading to a more or less common acceptance of a notion of the ‘global’ as a privileged concept in contemporary cultural debates.
Ausentes presentes: Art Music from the Chilean Exile in the Anacrusa Festivals at the Goethe-Institute Santiago (1985–89)
Authors: FUGELLIE DANIELA 
Published: October 2020

AbstractCreated in 1984, the Anacrusa Music Association organized concerts, workshops, and festivals of contemporary music in Chile during the last years of Pinochet's military dictatorship. Crucial for these events was the collaboration with the Goethe-Institute Santiago, which enabled a space for free expression within the repressive context of the dictatorship. This article explores the circulation and reception of musical works by Chilean composers living in exile performed in the 1985, 1987, and 1989 Anacrusa festivals. The trajectories of the pieces by three main figures of the politically engaged avant-garde of the 1960s – Gustavo Becerra-Schmidt, Sergio Ortega, and Fernando García – can be seen as a transfer process that involved the goals of West German cultural diplomacy in Chile, as well as the interaction between Anacrusa organizers, Latin American colleagues, and performers who returned from exile.
Evaluation of yield of safflower (Carthamus tinctoriusL.) genotypes under semi-arid conditions
Authors: Mousavi Ojaq Seyed Mojtaba , Mozafari Hamid , Jabbari Hamid , Sani Behzad 
Published: October 2020

AbstractTo identify appropriate genotypes for breeding varieties suitable for semi-arid areas, yield components, as well as morphophonological traits of 127 safflower genotypes, were assessed at the Seed and Plant Improvement Institute, Iran. Cluster analysis revealed four distinct groups. The largest group (third cluster) includes 48 genotypes with characteristics such as mostly yellow-coloured flowers, mostly thorny with few thistle genotypes, relatively early-flowering, relatively high number of heads and grains per plant, highest 1000-grain weight with the highest grain yields. In contrast, the smallest group (second cluster) contains 13 genotypes with characteristics such as yellow florets, semi-dwarf, thorny, moderately late-flowering, low number of heads per plant and number of grains per head, low 1000-grain weight, and low grain yield. Principal component analysis results showed that the three components accounted for 29.5, 15.9 and 11.1% of the total variation, respectively. Graphic representation of the biplots based on the first and second principal components showed that the experimental genotypes were classified into four groups. The results also indicated that stem diameter, the number of branches, heads per plant and grains per head had the highest correlation with the first component, and grain yield, flower colour, flowering initiation and plant height had the highest correlation with the second component. These traits can be considered as an appropriate index for the selection of elite safflower genotypes for breeding varieties suited to cultivation in semi-arid conditions.
Associations of Police Officer Health Behaviors and Subjective Well-Being
Authors: Baker Lucas D. , Berghoff Christopher R. , Kuo Jennifer L. , Quevillon Randal P. 
Published: October 2020

Abstract. Background: Law enforcement officers (LEOs) are responsible for maintaining public order and safety within communities. As a consequence of this obligation, LEOs are repeatedly exposed to a myriad of unavoidable occupational stressors, known to affect health behaviors and well-being. Importantly, LEO well-being has public safety implications as those reporting higher well-being exhibit more equitable police behavior relative to those reporting lower well-being. Aims: The present study aimed to identify factors that may be leveraged to enhance LEO well-being by investigating the indirect relation of health behaviors to well-being through psychological flexibility. Method: Path-analytic regression models were used to analyze cross-sectional data provided by LEOs recruited from three geographically dispersed police agencies ( N = 459; Male = 84.7%, White = 64.2%). Results: Results indicated psychological flexibility accounted for the relations of chronic pain and quality sleep to well-being. Regular exercise accounted for the largest proportion of well-being variance, though the indirect effect through psychological flexibility was not significant. Limitations: Inclusion of more comprehensive measures of well-being and health behaviors may further clarify the strength of relations reported herein. Conclusion: Enhancing flexible response styles may support high well-being in LEO populations who report poor sleep quality and chronic pain.
Mechanical Amorphization of Synthetic Fault Gouges During Rotary‐Shear Friction Experiments at Subseismic to Seismic Slip Velocities
Authors: Kaneki S. , Oohashi K. , Hirono T. , Noda H. 
Published: October 2020

AbstractAlthough the effects of mechanical amorphization by fault motion on fault rocks have been investigated both in nature and experiments, the relationship between slip processes and the amount of amorphous materials produced remains unclear. We performed rotary‐shear friction experiments on synthetic quartz and kaolinite gouges at room temperature, normal stresses of 1 or 3 MPa, slip velocities of 0.001 or 1 m s−1, and displacements of 1–101 m. X‐ray diffraction and microscopic observation data revealed that mechanical amorphization in both materials was accompanied by grain‐size reduction, particle rounding, and the formation of ultrafine particles. The amount of amorphous materials produced was strongly dependent on mineralogy and total frictional work regardless of slip velocity. Therefore, mechanical amorphization can occur during both coseismic and subseismic slip. Amorphization of ~7 wt% of quartz gouge required 30.33 MJ kg−1 of frictional work, whereas for kaolinite gouge, only 0.77 MJ kg−1 was required, which is consistent with observed preferential amorphization of clay minerals in faults. For kaolinite, up to 6% of frictional work can be used for mechanical amorphization, indicating its potential importance for faulting energetics. Because some kinds of amorphous phyllosilicates release water at lower temperature than crystalline, mechanical amorphization of fault rocks may influence thermochemical pressurization. Gradual weakening of quartz gouge at 0.001 m s−1 slip velocity suggested that <4 wt% of amorphous silica can weaken a fault by amorphous silica‐related lubrication. Mechanical amorphization may accelerate pressure solution healing of faults if dissolution can occur under high porous conditions.
Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
Authors: Morotti Matteo , Zois Christos E. , El-Ansari Rokaya , Craze Madeleine L. , Rakha Emad A. , Fan Shih-Jung , Valli Alessandro , Haider Syed , Goberdhan Deborah C. I. , Green Andrew R. , Harris Adrian L. 
Published: October 2020

Abstract
Background
Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the intracellular Gln pathway, few reports have focussed on Gln transporters in breast cancer and TNBC.

Methods
The role and localisation of the Gln transporter SLC38A2/SNAT2 in response to Gln deprivation or pharmacological stresses was examined in a panel of breast cancer cell lines. Subsequently, the effect of SLC38A2 knockdown in Gln-sensitive cell lines was analysed. The prognostic value of SLC38A2 in a cohort of breast cancer was determined by immunohistochemistry.

Results
SLC38A2 was identified as a strongly expressed amino acid transporter in six breast cancer cell lines. We confirmed an autophagic route of degradation for SLC38A2. SLC38A2 knockdown decreased Gln consumption, inhibited cell growth, induced autophagy and led to ROS production in a subgroup of Gln-sensitive cell lines. High expression of SLC38A2 protein was associated with poor breast cancer specific survival in a large cohort of patients (p = 0.004), particularly in TNBC (p = 0.02).

Conclusions
These results position SLC38A2 as a selective target for inhibiting growth of Gln-dependent breast cancer cell lines.
AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
Authors: Yao Catherine D. , Haensel Daniel , Gaddam Sadhana , Patel Tiffany , Atwood Scott X. , Sarin Kavita Y. , Whitson Ramon J. , McKellar Siegen , Shankar Gautam , Aasi Sumaira , Rieger Kerri , Oro Anthony E. 
Published: October 2020

AbstractTumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistance. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amplifies noncanonical Gli1 activity, but characteristics and drivers of the nMRTF cell state remain unknown. Here, we use single cell RNA-sequencing of patient tumors to identify three prognostic surface markers (LYPD3, TACSTD2, and LY6D) which correlate with nMRTF and resistance to SMO inhibitors. The nMRTF cell state resembles transit-amplifying cells of the hair follicle matrix, with AP-1 and TGFß cooperativity driving nMRTF activation. JNK/AP-1 signaling commissions chromatin accessibility and Smad3 DNA binding leading to a transcriptional program of RhoGEFs that facilitate nMRTF activity. Importantly, small molecule AP-1 inhibitors selectively target LYPD3+/TACSTD2+/LY6D+ nMRTF human BCCs ex vivo, opening an avenue for improving combinatorial therapies.
Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
Authors: Woodcock D. J. , Riabchenko E. , Taavitsainen S. , Kankainen M. , Gundem G. , Brewer D. S. , Ellonen P. , Lepistö M. , Golubeva Y. A. , Warner A. C. , Tolonen T. , Jasu J. , Isaacs W. B. , Emmert-Buck M. R. , Nykter M. , Visakorpi T. , Bova G. S. , Wedge D. C. 
Published: October 2020

AbstractThe evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tumor DNA extracted from blood and cerebrospinal fluid. Substantial evolution occurs within the prostate, resulting in branching into multiple spatially intermixed lineages. One dominant lineage emerges that initiates and drives systemic metastasis, where polyclonal seeding between sites is common. Routes to metastasis differ between patients, and likely genetic drivers of metastasis distinguish the metastatic lineage from the lineage that remains confined to the prostate within each patient. Body fluids capture features of the dominant lineage, and subclonal expansions that occur in the metastatic phase are non-uniformly represented. Cerebrospinal fluid analysis reveals lineages not detected in blood-borne DNA, suggesting possible clinical utility.
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden
Authors: Rudberg Ann-Sofie , Havervall Sebastian , Månberg Anna , Jernbom Falk August , Aguilera Katherina , Ng Henry , Gabrielsson Lena , Salomonsson Ann-Christin , Hanke Leo , Murrell Ben , McInerney Gerald , Olofsson Jennie , Andersson Eni , Hellström Cecilia , Bayati Shaghayegh , Bergström Sofia , Pin Elisa , Sjöberg Ronald , Tegel Hanna , Hedhammar My , Phillipson Mia , Nilsson Peter , Hober Sophia , Thålin Charlotte 
Published: October 2020

AbstractSARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6–39.5) and ageusia (OR 19.2, 95% CI 14.3–26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9–4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2–5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community.
Two distinct immunopathological profiles in autopsy lungs of COVID-19
Authors: Nienhold Ronny , Ciani Yari , Koelzer Viktor H. , Tzankov Alexandar , Haslbauer Jasmin D. , Menter Thomas , Schwab Nathalie , Henkel Maurice , Frank Angela , Zsikla Veronika , Willi Niels , Kempf Werner , Hoyler Thomas , Barbareschi Mattia , Moch Holger , Tolnay Markus , Cathomas Gieri , Demichelis Francesca , Junt Tobias , Mertz Kirsten D. 
Published: October 2020

AbstractCoronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) and normal lung tissues (n = 9 tissues from 6 patients). Two distinct immunopathological reaction patterns of lethal COVID-19 are identified. One pattern shows high local expression of interferon stimulated genes (ISGhigh) and cytokines, high viral loads and limited pulmonary damage, the other pattern shows severely damaged lungs, low ISGs (ISGlow), low viral loads and abundant infiltrating activated CD8+T cells and macrophages. ISGhighpatients die significantly earlier after hospitalization than ISGlowpatients. Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment.
Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Authors: Perez-Alvarez Alberto , Yin Shuting , Schulze Christian , Hammer John A. , Wagner Wolfgang , Oertner Thomas G. 
Published: October 2020

AbstractIn hippocampal pyramidal cells, a small subset of dendritic spines contain endoplasmic reticulum (ER). In large spines, ER frequently forms a spine apparatus, while smaller spines contain just a single tubule of smooth ER. Here we show that the ER visits dendritic spines in a non-random manner, targeting spines during periods of high synaptic activity. When we blocked ER motility using a dominant negative approach against myosin V, spine synapses became stronger compared to controls. We were not able to further potentiate these maxed-out synapses, but long-term depression (LTD) was readily induced by low-frequency stimulation. We conclude that the brief ER visits to active spines have the important function of preventing runaway potentiation of individual spine synapses, keeping most of them at an intermediate strength level from which both long-term potentiation (LTP) and LTD are possible.