bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review on the relationship between international migration and antimicrobial resistance
Authors: Peters Anne Sophie , Cabieses Báltica , Ramirez Orlando , Uphoff Eleonora , Acuña María Paz , Astorga Sofía , Araos Rafael , Munita José Manuel 
Published: July 2020

Abstract
Introduction: Antimicrobial drug resistance (AMR) is considered a serious threat to public health worldwide. The relation between AMR and human mobility, particularly international migration, has drawn attention from the scientific community in recent years. However, several aspects about this relation remain unclear. Therefore, we aimed at expanding and updating previous systematic review studies, with a novel focus on the AMR prevalence in migrants compared to the local population of the host country, to examine external validity of previous findings.Methods: We searched in Ovid MEDLINE all types of observational studies, without language or year of publication restrictions. We aimed at exploring differences in countries´ bacterial drug resistance rates based on immigration rates. All types of AMR were included, except for those related to HIV/AIDS and Tuberculosis. The comparator group of interest was the local population of the host country. The study protocol is registered with PROSPERO, number CRD42018114436. Results: After screening of 322 articles, 15 papers were selected for data extraction, including 1930 migrants. Compared to the local population, higher rates of methicillin-resistant Staphylococcus aureus, Panton-Valentine leucocidin positive strains, multidrug-resistant Gram-negative bacteria, vancomycin-resistant Enterococcus, and having at least one multidrug-resistant organism were found in migrants in 12 of the 15 papers. Rates of AMR did not differ significantly in two studies and only one of them reported a lower burden of AMR in migrants.Conclusions: Higher prevalence of AMR in migrants were presented in the majority of the included articles, addressing the emerge of the circulation of resistant strains within this group. More detailed descriptions, including time span and route taken by migrants to arrive to country of destination and length of stay by the time of inclusion are essential to gain a deeper understanding of the relation in between AMR and migration. Countries with high migration rates outside Europe should be encouraged to implement strategies for screening of both local population and migrants in countries.
Human Myeloid-derived Suppressor Cells Derived From the Bone Marrow Are Decreased With Age but Maintain Their Functional Ability
Authors: Magri Sara , Masetto Elena , Solito Samantha , Francescato Samuela , Belluzzi Elisa , Pozzuoli Assunta , Berizzi Antonio , Ruggieri Pietro , Mandruzzato Susanna 
Published: July 2020

Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are known toinhibit the functions of effector T cells. During aging, several changes occur both at the adaptive and innate immune system level, in a process defined as immunoscenescence. In particular, the low-grade inflammation state observed in the elderly appears to affect hematopoiesis. We previously demonstrated that the combination of GM-CSF and G-CSF drives the in vitro generation of bone marrow-derived MDSCs (BM-MDSCs) from precursors present in human bone marrow aspirates of healthy donors, and that these cells are endowed with a strong immune suppressive ability, resembling that of cancer-associated MDSCs. In the present work we investigated BM-MDSCs induction and functional ability in a cohort of pediatric versus elderly donors. To this aim, we analyzed the differences in maturation stages and ability to suppress T cell proliferation. We found that the ex vivo distribution of myeloid progenitors is similar between pediatric and elderly individuals, whereas after cytokine treatment a significant reduction in the more immature compartment is observed in the elderly. Despite the decreased frequency, BM-MDSCs maintain their suppressive capacity in aged donors. Taken together, these results indicate that in vitro induction of MDSCs from the BM is reduced with aging and opens new hypotheses onthe role of age-related processes in myelopoiesis.
Hospital dental care for a post-cerebral infarction patient
Authors: Nascimento Paulo Pereira do , Patrocínio Victor Hugo , Oliveira Renata Lanzoni de , Paiva-Oliveira Janayna Gomes , Gaetti-Jardim Ellen Cristina 
Published: July 2020

Stroke presents as a deficiency of cerebral blood supply lowering the oxygen level and increasing the chance of irreversible tissue damage being such severity proportional to the extent and type of tissue injury, requiring immediate multiprofessional support. Thus, the objective is to present a clinical case of a 85-year-old female patient with stroke who underwent invasive dental treatment to eliminate the foci of infection and comfort to the patient concomitant to the hospitalization.Descriptors: Cerebral Infarction; Dental Care; Dental Service, Hospital; Ambulatory Care.ReferênciasWorld Health Organization. (WHO). The top 10 causes of death. [Internet] Geneva; 2014. [Cited in 2016 Nov 22]. Available from: http://www.who. int/mediacentre/factsheets/fs310/em.Brasil. Ministério da saúde. Informações de saúde TABNET- Estatísticas vitais. Datasus. [internet]. [Citado em 2016 nov 22]. Disponível em: http://tabnet.datasus.gov.brGhizoni JS, Taveira LAA, Garlet GP, Ghizoni MF, Pereira JR, Dionisio TJ et al. Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study. J Appl Oral Sci. 2012;20(1):104-12.Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000; 71(10):1551-60.Seitz MW, Listl S, Bartols A, Schubert I, Blaschke K, Haux C et al. Current knowledge on correlations between highly prevalent dental conditions and chronic diseases: an umbrella review. Prev Chronic Dis. 2019;16:180641Silva EJA. Reabilitação após o AVC [dissertação]. Porto: Faculdade de Medicina - Universidade de Porto; 2010.Patrocinio VH, Nascimento PP, Oliveira RL, Seco AJL, Fonseca RCL, Gaetti-Jardim EC. Extensa úlcera bucal em paciente com lúpus eritematoso. Rev Bras Ter Intensiva. 2019;31(2):266-68.Scannapieco FA, Genco RJ. Association of periodontal infections with atherosclerotic and pulmonary diseases. J Period Res. 1999;34(7):340-45.Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin. E Periodontal Infections Contribute to Elevated Systemic C-Reactive Protein Level. J Periodontol. 2001;72(9):1221-27.Hashemipour MA, Afshar AJ, Borna R, Seddighi B, Motamedi A. Gingivitis and periodontitis as a risk factor for stroke: A case-control study in the Iranian population. Dent Res J (Isfahan). 2013;10(5):613-19.
Effect of temperature and duration of pyrolysis on spent tea leaves biochar: physiochemical properties and Cd(II) adsorption capacity
Authors: Yang Zhanbiao , Liu Xincong , Zhang Mengdi , Liu Lixia , Xu Xiaoxun , Xian Junren , Cheng Zhang 
Published: July 2020

AbstractWe analyzed the effects of pyrolysis temperature and duration on the physiochemical properties and Cd(II) adsorption capacity of spent tea leaves (STL) biochar. The STL biochar was produced by pyrolysis at 300, 400, 500 and 600 °C for 1 and 2 h. The pyrolysis temperature was positively correlated to the ash content, pH, electrical conductivity, specific surface area (SBET), pore volume (PV) and C content, and negatively with the total yield, O, H and N content, and the O/C and H/C atomic ratios. Furthermore, the surface porosity of STL biochar increased, the density of oxygen-containing functional groups decreased, and the formation of aromatic structures was enhanced at higher pyrolysis temperatures. The adsorption of Cd(II) onto STL biochar fitted with the pseudo-second-order kinetics and Langmuir isotherms model. The STL biochar produced at 600 °C for 2 h showed the maximum Cd(II) adsorption capacity of 97.415 mg/g. In addition, Cd(II) adsorption was mainly physical and occurred in monolayers. Thus, STL biochar is a suitable low-cost adsorbent for wastewater treatment.
Lewis Acid-Mediated Efficient Synthesis of 4H-1,3-benzo-xazines and Their Derivatives 4,5-dihydro-1,3-benzo-xazepines
Authors: Junkai An , Jikun Liu , Ying Shi , Weiwei Zhu , Guoying Guo , Xianxing Jiang , Jijun Xue , Hongrui Zhang 
Published: July 2020

:
Compounds containing 4H-1,3-benzo-xazine core usually possess characteristic
features and have been applied in the fields of organic synthesis, pharmaceutical research,
materials science and bioscience. Here we reported convenient and direct access to 4H-1,3-
benzo-xazines and their derivatives through intramolecular cyclization of olefinic amides or
ureas with good to excellent yields in the presence of TMSOTf. The properties (mild conditions,
metal or additives-free, wide substrate scope and functional group tolerance) of the process
made it a promising strategy to synthesize various benzo-xazines and their derivatives.
Traceable Peptidic Ligands that Target Ghrelin Receptors
Authors: Liu Mengjie , Wade John , Hossain Mohammed Akhter 
Published: July 2020

:
Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological
and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor
using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of
the peptide’s signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based
ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural
features, pharmacological properties, and applications in further biochemical research.
Development of Pediatric Orodispersible Tablets Based on Efavirenz as a New Therapeutic Alternative
Authors: de Freitas Neto José Lourenço , do Nascimento Gomes Barbosa Ilka , de Melo Camila Gomes , Ângelos Matheus Alves , dos Santos Mendes Larissa Morgana , Ferreira Magda Rhayanny Assunção , Rolim Larissa Araújo , Soares Luiz Alberto Lira , da Silva Rosali Maria Ferreira , Neto Pedro José Rolim 
Published: July 2020

Background:
Efavirenz is the most used medication in the treatment of Acquired Immunodeficiency
Syndrome (AIDS). The limited number of pediatric antiretroviral formulations approved
by regulatory agencies is the most significant obstacle to adequate and efficient pharmacotherapy
for this group of patients. The efavirenz has excellent therapeutic potential, but has low
aqueous solubility/bioavailability.

Methods:
To minimize these limitations, multicomponent systems with β-cyclodextrin and polyvinylpyrrolidone
K-30 were obtained. Due to the limited number of pediatric antiretroviral formulations,
the development of a pediatric orodispersible tablet is an alternative that is thought easy to
administer, since it disintegrates rapidly in the oral cavity. The multicomponent systems were obtained
by the method of kneading and characterized by solubility test, X-ray diffraction, differential
scanning calorimetry and infrared absorption spectroscopy by Fourier transform. The orodispersible
tablets were prepared by direct compression. The quality control of hardness, friability, disintegration,
and dissolution was performed. The influence of the components of the formulation on the
characteristics of the tablets was evaluated through a 22 factorial design added with three central
points, to compare the effect of the dependent variables on the responses.

Results:
An increase in drug solubility was observed, with a decrease in crystallinity. Besides that,
an excellent dissolution profile presented with more than 83% of the drug's content dissolved in less
than 15 minutes. Satisfactory disintegration time and friability were observed.

Conclusion:
It was observed that reduced concentrations of mannitol decreased the hardness and
disintegration time of the formulations. The orodispersible tablet composed of efavirenz: β-
cyclodextrin: polyvinylpyrrolidone, favors greater absorption and bioavailability. It has several advantages
for pediatric patients, as the dosage form disintegrates quickly in the mouth and does not
require water for administration, thereby improving patient compliance with the treatment.
Combined CADD and Virtual Screening to Identify Novel Nonpeptidic Falcipain-2 Inhibitors
Authors: Rajguru Trisha , Bora Dipshikha , Modi Mahendra Kumar 
Published: July 2020

Background:
Plasmodium falciparum is the most dangerous and widespread diseasecausing
species of malaria. Falcipain-2 (FP2) of Plasmodium falciparum, is a potential target for
antimalarial chemotherapy since it is involved in an essential cellular function such as hemoglobin
degradation during the parasite’s life cycle. However, despite their central role in the life cycle of
the parasite, no commercial drug targeting Falcipain-2 has been developed to date. Prior efforts to
develop peptide-based drugs against Plasmodium have been futile due to their susceptibility to being
degraded by host enzymes.

Objective:
Here, we report computer-aided drug design of new nonpeptidic inhibitors against FP2,
which are likely to be safe from degradation by host enzymes.

Methods:
We have virtually screened for the probable FP2 inhibitors from the PubChem database
by submitting the well-equilibrated 3-D structure of FP2. Furthermore, virtual screenings and dockings
were carried out using PyRx and Discovery Studio.

Results:
We found 15 top-ranking molecules with carbaldehyde pharmacophore having a good fit
with the target protein. Based on the C-Docker values, the top 4 hits (PubChem 44138738, Pub-
Chem 20983198, PubChem 20983081 and PubChem 28951461) for FP2 were identified. These
four hits have been observed to bound to the active cleft of the protein. Moreover, their complexes
were also found to be stable from the RMSD and Radius of Gyration analysis.

Conclusion:
The selected compounds 2-(benzylamino)-8-methylquinoline-3-carbaldehyde (Pub-
Chem44138738), 6-bromo-2-(3,4-dihydro-1H-isoquinolin-2-yl)quinoline-3-carbaldehyde (Pub-
Chem 20983198), 2-(3,4-dihydro-1H-isoquinolin-2-yl)-6-ethylquinoline-3-carbaldehyde(PubChem
20983081)and 2-[benzyl(methyl)amino]quinoline-3-carbaldehyde (PubChem 28951461) may be
the starting point for further modification as a new type of nonpeptidic drug for malaria disease.
Piperine from Black Pepper Decreased the Expression of Intercellular Adhesion Molecule-1 in Macrophages
Authors: Gholijani Nasser , Hashemi Esmaeil , Amirghofran Zahra 
Published: July 2020

Background:
Macrophages are the main players involved in inflammation. Intercellular adhesion molecule-1
(ICAM-1) facilitates macrophage polarization prior to extravasation into inflamed tissue. Piperine a natural product derived
from black pepper possess useful biological and pharmacological activities. In current study, the possible anti-inflammatory
effect of piperine on the expression of ICAM-1 on J774.1 murine macrophage cell line was investigated.

Methods:
Lipopolysaccharide (LPS)-stimulated J774.1 cells were cultured in the presence of different concentrations of
piperine to examine the changes in ICAM-1 expression by real-time PCR and flow cytometry.

Results:
We found that piperine decreased ICAM-1 gene expression level from 2.4 ± 0.25 RFC
(relative fold change) in LPS-only treated cells to 0.85 ± 0.525 RFC at 1µg/ml (p<0.05), 0.43 ±
0.27 RFC at 10µg/ml (p<0.01), and 0.26 ± 0.25 RFC at 20µg/ml (p<0.01). In flow cytometry,
piperine at all concentrations significantly decreased ICAM-1 surface expressions (P<0.05). The
geometric mean fluorescence intensity (g-MFI) in LPS-only treated cells (792 ± 57.3) decreased to
482±70 g-MFI at 20 μg/ml piperine.

Conclusion:
According to the results of this study, by decreasing the expression of ICAM-1, piperine is suggested as a candidate to reduce inflammation and has the potential for therapeutic benefits for immune-mediated diseases.
Zinc Phosphate and Resin Cements Provide Similar Bonding of Cast Metal Post to Dentin
Authors: Ferreira Carolina J. , Benetti Paula , Nicolodi Karen , da Rocha Larissa S. , De Carli João P. 
Published: July 2020

Background:
Cast metal posts-and-core are frequently used to retain restorations to extensively
destroyed teeth. However, the influence of different cements on the posts bond strength to
dentin remains unclear. Objective: to evaluate the effect of different cements on the bond strength of
cast metal posts and dentin.

Methods:
Forty roots (14 mm length) of extracted human teeth were endodontically treated and prepared.
Impressions of each root canal were taken to obtain customized cast metal posts. The roots
were randomly divided into 4 groups (n=10): (1) ZP: zinc phosphate cement (non adhesive); (2)
ARC_Sin: Single Bond adhesive and RelyX ARC; (3) ARC_Sco: Scotchbond adhesive and RelyX
ARC; (4) U200: RelyX U200. After cementation, the samples were cross-sectioned to obtain specimens
of 1mm thickness. Push-out test was performed applying a compressive load (0.5 mm/min) to
the center of the metal post until failure. Bond strength was calculated based on the diameter of the
root canal and the thickness of each specimen. Data were analyzed using ANOVA and Tukey
(α=0.05). The fracture mode was analyzed.

Results:
Bond strength values were statistically similar between the groups (p>0.05). The fracture
analysis showed the prevalence of mixed fractures (cement partially attached to the dentin and/or
post). Experimental groups showed inexpressive amount of adhesive fractures (complete detachment
of the cement from dentin and/or post). The ARC_Sco and U200 groups presented higher prevalence
of dentin cohesive fracture.

Conclusion:
Bonding had no influence on the immediate bond strength between cast metal posts and
root canal dentin.
Transit Oriented Development and Ridership at Kelana Jaya Line LRT Stations
Authors: Baharom Shah Muhammad Ikram , Abdullah Jamalunlaili , Rashid Kushairi 
Published: July 2020

Transit-Oriented Developments (TOD) which promotes high density and mixed-use development around transit centres may affect the success of mass rapid transit. This paper analyses the correlation between land use, economic activities around the stations, and the number of riders using the LRT Kelana Jaya Line in Subang Jaya, Malaysia as the case study. It compares the ridership data with Land Use Public Transport Accessibility Index (LUPTAI) for selected stations. This study finds that there is a positive correlation between the LUPTAI and the ridership numbers, suggesting that land use developments around the stations do affect the ridership. Keywords: Transit-oriented development; land use; ridership. eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI:
Evaluating Smart Assistant Responses for Accuracy and Misinformation Regarding Human Papillomavirus Vaccination: Content Analysis Study
Authors: Ferrand John , Hockensmith Ryli , Houghton Rebecca Fagen , Walsh-Buhi Eric R 
Published: July 2020

Background
Almost half (46%) of Americans have used a smart assistant of some kind (eg, Apple Siri), and 25% have used a stand-alone smart assistant (eg, Amazon Echo). This positions smart assistants as potentially useful modalities for retrieving health-related information; however, the accuracy of smart assistant responses lacks rigorous evaluation.

Objective
This study aimed to evaluate the levels of accuracy, misinformation, and sentiment in smart assistant responses to human papillomavirus (HPV) vaccination–related questions.

Methods
We systematically examined responses to questions about the HPV vaccine from the following four most popular smart assistants: Apple Siri, Google Assistant, Amazon Alexa, and Microsoft Cortana. One team member posed 10 questions to each smart assistant and recorded all queries and responses. Two raters independently coded all responses (κ=0.85). We then assessed differences among the smart assistants in terms of response accuracy, presence of misinformation, and sentiment regarding the HPV vaccine.

Results
A total of 103 responses were obtained from the 10 questions posed across the smart assistants. Google Assistant data were excluded owing to nonresponse. Over half (n=63, 61%) of the responses of the remaining three smart assistants were accurate. We found statistically significant differences across the smart assistants (N=103, χ22=7.807, P=.02), with Cortana yielding the greatest proportion of misinformation. Siri yielded the greatest proportion of accurate responses (n=26, 72%), whereas Cortana yielded the lowest proportion of accurate responses (n=33, 54%). Most response sentiments across smart assistants were positive (n=65, 64%) or neutral (n=18, 18%), but Cortana’s responses yielded the largest proportion of negative sentiment (n=7, 12%).

Conclusions
Smart assistants appear to be average-quality sources for HPV vaccination information, with Alexa responding most reliably. Cortana returned the largest proportion of inaccurate responses, the most misinformation, and the greatest proportion of results with negative sentiments. More collaboration between technology companies and public health entities is necessary to improve the retrieval of accurate health information via smart assistants.