bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidomics reveal the protective effects of a vegetable-derived isothiocyanate against retinal degeneration
Authors: Kwa Faith A. , Dulull Nabeela K. , Roessner Ute , Dias Daniel A. , Rupasinghe Thusitha W. 
Published: February 2020

Background:Age-related macular degeneration (AMD) is a leading cause of blindness in the ageing population. Without effective treatment strategies that can prevent disease progression, there is an urgent need for novel therapeutic interventions to reduce the burden of vision loss and improve patients’ quality of life. Dysfunctional innate immune responses to oxidative stress observed in AMD can be caused by the formation of oxidised lipids, whilst polyunsaturated fatty acids have shown to increase the risk of AMD and disease progression in affected individuals. Previously, our laboratory has shown that the vegetable-derived isothiocyanate, L-sulforaphane (LSF), can protect human adult pigment epithelial cells from oxidative damage by upregulating gene expression of the oxidative stress enzyme Glutathione-S-Transferase µ1. This study aims to validate the protective effects of LSF on human retinal cells under oxidative stress conditions and to reveal the key players in fatty acid and lipid metabolism that may facilitate this protection.Methods:Thein vitrooxidative stress model of AMD was based on the exposure of an adult retinal pigment epithelium-19 cell line to 200µM hydrogen peroxide. Percentage cell proliferation following LSF treatment was measured using tetrazolium salt-based assays. Untargeted fatty acid profiling was performed by gas chromatography-mass spectrometry. Untargeted lipid profiling was performed by liquid chromatography-mass spectrometry.Results:Under hydrogen peroxide-induced oxidative stress conditions, LSF treatment induced dose-dependent cell proliferation. The key fatty acids that were increased by LSF treatment of the retinal cells include oleic acid and eicosatrienoic acid. LSF treatment also increased levels of the lipid classes phosphatidylcholine, cholesteryl ester and oxo-phytodienoic acid but decreased levels of phosphatidylethanolamine lipids.Conclusions:We propose that retinal cells at risk of oxidative damage and apoptosis can be pre-conditioned with LSF to regulate levels of selected fatty acids and lipids known to be implicated in the pathogenesis and progression of AMD.
SNPector: SNP inspection tool for diagnosing gene pathogenicity and drug response in a naked sequence
Authors: Habib Peter T. , Alsamman Alsamman M. , Hassanein Sameh E. , Shereif Ghada A. , Hamwieh Aladdin 
Published: February 2020

Due to the ability to diagnose diseases early and evaluate the effectiveness of medicinal drugs, single nucleotide polymorphism (SNP) identification receives significant interest. Detection and diagnosis of genetic variation through skill-less computational tools would help researchers reducing the severity of such health complications and improving well-tailored therapies using discovered and previously known information. We introduce SNPector, which is a standalone SNP inspection software, which can be used to diagnose gene pathogenicity and drug reaction in naked genomic sequences. It identifies and extracts gene-related SNPs, and reports their genomic position, associated phenotype disorder, associated diseases, linkage disequilibrium, in addition to various drug reaction information. SNPector detects and verifies the existence of an SNP in a given DNA sequence without the reference based on different clinically relevant SNP databases, such as NCBI ClinVar, AWESOME, and PharmGKB, and generates highly informative visualizations of the recovered information.
Agricultural entomology in the state of Acre: a historical overview and future challenges
Authors: Sutil Weidson Plauter , Santos Rodrigo Souza 
Published: February 2020

In the state of Acre, Brazil, family-based agriculture is predominant and although it has less economic impact in relation to large-scale plantations, it is also subject to biological imbalances, such as the attack of pests, generating economic losses for producers. Phytosanitary knowledge in the state is still incipient and becomes an obstacle to production, often resulting in mistaken management decisions. In this context, this work aimed to present a history of research carried out in the field of Agricultural Entomology, especially in the areas of integrated management and biological control of pests of the most relevant crops grown in the Acre state. In this review, 55 scientific papers related to Agricultural Entomology were presented, 23 on new insect records and/or new insect associations with host plants, 16 on insect control using plant extracts from the Amazon region, 13 on integrated pest management and three on bioecology and population dynamics of pests in the state of Acre. Through this review, it is observed that research in the area of Agricultural Entomology in the state of Acre is characterized by basic research (surveys, registration of new species, bioecological and dynamic population studies). However, there has been a notable advance in scientific studies aimed at integrated pest management in the state in the past ten years. Still, there is a need to concentrate efforts on research aimed at prospecting and using Amazonian biodiversity (fauna and flora), which subsidize applied programs for integrated pest management of the main crops grown in the Acre state.
Trampoline-related proximal tibia impaction fractures in children: A population-based approach to epidemiology and radiographic findings between 2006 and 2017
Authors: Jääskelä Maija , Kuivalainen Laura , Victorzon Sarita , Serlo Willy , Lempainen Lasse , Sinikumpu Juha-Jaakko 
Published: February 2020

Purpose Proximal tibia impaction fractures are specific injuries, usually caused by trampolining. They may associate with later growth disturbances. There is sparse understanding about their recent epidemiology, in particular the changing incidence. Their typical radiographic findings are not completely known. Methods All children, aged < 16 years, who had suffered from proximal tibia fracture in Oulu Arc and Oulu between 2006 and 2017 were enrolled (n = 101). Their annual incidence was determined using the official population-at-risk, obtained from the Statistics Finland. The specific characteristics and risk factors of the patients and their fractures were evaluated. Radiographic findings were analyzed, in particular the anterior tilting of the proximal growth plate, due to impaction. Results The annual incidence increased two-fold from 9.5 per 100 000 children (2006 to 2009) to 22.0 per 100 000 (2014 to 2017) (difference: 12.5; 95% confidence interval 5.1 to 20.3 per 100 000; p = 0.0008). The mean annual incidence of trampoline impaction leg fractures was 15.4 per 100 000 children. In 80% of the cases multiple children had been jumping together on the trampoline. Anterior tilting (mean 7.3°, SD 2.5°, 6.1° to 19.1°)) of the proximal tibial plate was seen in 68.3% of the patients. Satisfactory bone union was found in 92.7% during follow-up. Isolated patients presented delayed bone healing. Conclusion The incidence of trampoline leg fractures has increased 130% during the 12 years of the study period. Many of these injuries could have been prevented by avoiding having several jumpers on the trampoline at the same time. Anterior tilting of the growth plate was a common finding and should be recognized in the primary radiographs. Level of evidence IV
GNPy: an open source application for physical layer aware open optical networks
Authors: Ferrari Alessio , Filer Mark , Balasubramanian Karthikeyan , Yin Yawei , Le Rouzic Esther , Kundrát Jan , Grammel Gert , Galimberti Gabriele , Curri Vittorio 
Published: February 2020

In this paper, we describe the validation of GNPy. GNPy is an open source application that approaches the optical layer according to a disaggregated paradigm, and its core engine is a quality-of-transmission estimator for coherent wavelength division multiplexed optical networks. This software is versatile. It can be used to prepare a request for proposal/request for quotation, as an engine of a what-if analysis on the physical layer, to optimize the network configuration to maximize the channel capacity, and to investigate the capacity and performance of a deployed network. We validate GNPy by feeding it with data from the network controller and comparing the results to experimental measurements on mixed-fiber, Raman-amplified, multivendor scenarios over the full C-band. We then test transmission distances from 400 up to 4000 km, polarization-multiplexed (PM) quadrature phase shift keying, the PM-8 quadrature amplitude modulation (QAM) and PM-16QAM formats, erbium-doped fiber amplifier (EDFA) and mixed Raman–EDFA amplification, and different power levels. We show excellent accuracy in predicting both the optical signal-to-noise ratio and the generalized signal-to-noise ratio (GSNR), within 1 dB accuracy for more than 90% of the 500 experimental samples. We also demonstrate the ability to estimate the transmitted power maximizing the GSNR within 0.5 dB of accuracy.
Widely tunable polarization conversion in low-doped graphene-dielectric metasurfaces based on phase compensation
Authors: Guan Shengnan , Cheng Jierong , Chen Tiehong , Chang Shengjiang 
Published: February 2020

We propose a tri-band half-wave plate in the reflection mode, composed of rectangular silicon bar arrays on a 10-layer graphene substrate. By merely varying the Fermi energy of graphene from 0 to 0.25 eV, the three frequency bands shift in step and merge to a continuous dynamic bandwidth from 0.88 to 1.81 terahertz (THz). In addition, it can also dynamically switch the reflected wave among cross-linear polarization, right-handed and left-handed circular polarization in 0.93–1.35 THz. We found that the large dynamic bandwidth originates from the tunable reflection phase from the graphene layers. As it no longer depends on the plasmonic resonance in graphene, the proposed hybrid metasurface offers an alternative solution for active THz polarization devices with low biasing voltages.
High-speed dual-view photoacoustic imaging pen
Authors: Zhang Wuyu , Ma Haigang , Cheng Zhongwen , Wang Zhiyang , Xiong Kedi , Yang Sihua 
Published: February 2020

Today, photoacoustic imaging (PAI) is widely used to study diseases in the skin, brain, cardiovascular, and other parts. However, these studies are often carried out using physiological slices or model animals, which indicate that many PAI techniques can only be used in the laboratory. In order to promote the transformation of PAI into clinical applications or, more specifically, to extend the application of photoacoustic (PA) microscopy to areas such as the oral cavity, throat, cervix, and abdominal viscera which are difficult to detect with conventional PA microscopy systems, a PAI pen was developed. The PAI pen can be handheld and can perform forward detection and lateral detection. The imaging area is a 2.4 mm diameter circular area. In addition, it can provide a high-speed imaging mode of four frames per second and a high-resolution imaging mode of 0.25 frames per second to meet the different needs of clinical users. In this Letter, the performance of the PAI pen was tested by imaging the phantom and the human oral cavity. The experimental results prove that the PAI pen can clearly image the microvessels of the oral cavity, which indicates that it has the same imaging capability for other similar areas and has a good prospect for assisting the diagnosis of related diseases.
Cross-sectional research on sleep hygiene and health complaints among Pakistani college students
Authors: Rashid Arshi , Sahar Najam-us 
Published: February 2020

Abstract
With recent technological advancement, a major shift in the lifestyle of individuals has been observed. This change is more evident in youth in terms of sleep pattern changes and socialization. It is therefore important to assess the quality of life in this productive group of society. The protocol consisted of the Urdu version of the demographic questionnaires, the Pittsburgh Sleep Quality Index (PSQI), the Cohen-Hoberman Inventory of Physical symptoms (CHIPS) and the World Health Organization Quality of Life (WHOQOL-BREF). A total of 150 young adults (boys = 62, girls = 88) were included through convenience sampling. A significant positive association was found between poor sleep quality and health complaints (r = 0.53**). However, a significant negative association was found between poor sleep and quality of life in terms of physical health, psychological health, social relationships and the environment (r = −0.57**, −0.35**, −0.39**, −0.33**), respectively, which indicates the importance of sleep in determining quality of life. Furthermore, the majority of the participants (57%) reported good sleep quality and low health complaints [M = 15.08, standard deviation (SD) = 13.29] whereas 43% of participants reported poor sleep quality, more health complaints (M = 32.94, SD = 22.59) and poor quality of life. It shows that most of the participants are healthy and able to manage their daily routine, work commitment and provide services for country’s development.
Students’ Self-assessed Competence Levels during Nursing Education Continuum – A Cross-sectional Survey
Authors: Kajander-Unkuri Satu , Meretoja Riitta , Katajisto Jouko , Leino-Kilpi Helena , Suikkala Arja 
Published: February 2020

Abstract
During nursing education, nursing students are required to develop their competence to be able to fulfill their duties safely as Registered Nurses. The aims of this study were to explore 1) nursing students’ self-assessed competence levels during education 2) the relationship with competence and frequency at which competencies are utilized in clinical practice, and 3) factors related to competence levels. 841 (response rate 67.6 %) nursing students responded to the Nurse Competence Scale in a cross-sectional study. The self-assessed overall competence levels were improving during the education continuum (VAS-means 1st 56.6; 2nd 58.3; 3rd 59.8 and 3.5th -year students 68.4). Every group revealed a significant positive correlation with competence and frequency at which competencies are utilized in clinical practice in clinical placement. Risk factors for low competence were also identified. Systematic multimethod competence evaluations with longitudinal designs are needed to monitor outcomes of nursing education.
Modeling the Impact of Rain on Population Exposed to Air Pollution
Authors: Sharma Sandeep , Kumari Nitu 
Published: February 2020

Abstract
Air pollution is caused by contamination of air due to various natural and anthropogenic activities. The growing air pollution has diverse adverse effects on human health and other living species. However, a significant reduction in the concentration of air pollutants has been observed during the rainy season. Recently, a number of studies have been performed to understand the mechanism of removal of air pollutants due to the rain. These studies have found that rain is helpful in removing many air pollutants from the environment. In this paper, we proposed a mathematical model to investigate the role of rain in the removal of air pollutants and its subsequent impacts on the human population.
Elaboration, distanciation, polynomie: naissance et feux croisés de la sociolinguistique corse
Authors: Thiers Jacques 
Published: February 2020

Abstract
This article proposes to return to the “birth” of Corsican sociolinguistics and the main notions that fuelled the emergence of Corsican as “language”. The reflection goes back to the development of the 1970s and 1980s in order to better understand the context of the time and the reasons that allowed such a birth. It will also highlight the contribution of the main figures of this period and the constant relationship with Corsican sociolinguists. Two important figures emerge from this dialogue, notably Heinz Kloss and Jean-Baptiste Marcellesi whose theories have been taken up and crossed to characterize the evolution of the Corsican situation. Thus, discussed here are, in particular, the concepts of elaboration, distancing and polynomie.
Chestnut beer, Corsica-Cola, and wine bottles: The commodification of Corsican in the linguistic and semiotic landscapes of the island’s drinks industry
Authors: Blackwood Robert 
Published: February 2020

Abstract
Within sociolinguistics, work on the commodification of language has gathered pace in recent decades. Monica Heller, in “Globalisation, the new economy, and the commodification of language and identity”, published in 2003 in the Journal of Sociolinguistics, contends that in the new globalized economy, language is commodified as a measurable skill, an inalienable characteristic of group members, and a marker of authenticity. Whilst the ability to speak Corsican is a potential aspect of the commodification of the language on the island, this article will explore in particular the extent to which the Corsican language is a characteristic of Corsican-ness, as well as a marker of value and authenticity in the economic market on the island (see Monica Heller and Alexandre Duchêne, “Pride and profit: changing discourses of language, capital, and nation-state”, published in 2012 in Language in late capitalism: pride and profit). Based on a corpus of product labelling from Corsican soft and alcoholic drinks, I investigate the extent to which Corsican, as a named language, and other visual resources are used for meaning-making in the presentation of local products. In doing so, I consider here the unevenness in the use of Corsican in the labelling of drinks which reflects the contours of regional language revitalisation and the shifting cultural value attributed to both French and Corsican depending on the product that retailers are seeking to sell.
Effects of gabapentinoids on responses of primary cultures from rat dorsal root ganglia to inflammatory or somatosensory stimuli
Authors: Leisengang Stephan , Ott Daniela , Murgott Jolanta , Nürnberger Franz , Gerstberger Rüdiger , Rummel Christoph , Schmidt Martin , Roth Joachim 
Published: February 2020

Abstract

Background
Gabapentinoids are known to reduce neuropathic pain. The aim of this experimental study was to investigate whether gabapentinoids exert anti-inflammatory and/or anti-nociceptive effects at the cellular level using primary cultures of rat dorsal root ganglia (DRG).

Methods
Cells from rat DRG were cultured in the presence of gabapentin or pregabalin, and we tested the effects of subsequent stimulation with lipopolysaccharide (LPS) on the expression of genes (real-time polymerase chain reaction) and production of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) by specific bioassays. Using Ca2+ imaging, we further investigated in neurons the effects of gabapentinoids upon stimulation with the TRPV-1 agonist capsaicin.

Results
There is a small influence of gabapentinoids on the inflammatory response to LPS stimulation, namely, a significantly reduced expression of IL-6. Pregabalin and gabapentin further seem to exert a moderate inhibitory influence on capsaicin-induced Ca2+ signals in DRG neurons.

Conclusions
Although the single inhibitory effects of gabapentinoids on inflammatory and nociceptive responses are moderate, a combination of both effects might provide an explanation for the proposed function of these substances as an adjuvant for the reduction of neuropathic pain.
Numerics of acoustical 2D tomography based on the conservation laws
Authors: Kabanikhin Sergey I. , Klyuchinskiy Dmitriy V. , Novikov Nikita S. , Shishlenin Maxim A. 
Published: February 2020

Abstract
We investigate the mathematical modeling of the 2D acoustic waves propagation, based on the conservation laws.
The hyperbolic first-order system of partial differential equations is considered and solved by the method of S. K. Godunov.
The inverse problem of reconstructing the density and the speed of sound of the medium is considered.
We apply the gradient method to reconstruct the parameters of the medium.
The gradient of the functional is obtained.
Numerical results are presented.
Strong and weak convergence of Ishikawa iterations for best proximity pairs
Authors: Gabeleh Moosa , Manna S. I. Ezhil , Eldred A. Anthony , Otafudu Olivier Olela 
Published: February 2020

Abstract
Let A and B be nonempty subsets of a normed linear space X. A mapping T : A ∪ B → A ∪ B is said to be a noncyclic relatively nonexpansive mapping if T(A) ⊆ A, T(B) ⊆ B and ∥Tx − Ty∥ ≤ ∥x − y∥ for all (x, y) ∈ A × B. A best proximity pair for such a mapping T is a point (p, q) ∈ A × B such that p = Tp, q = Tq and d(p, q) = dist(A, B). In this work, we introduce a geometric notion of proximal Opiaľs condition on a nonempty, closed and convex pair of subsets of strictly convex Banach spaces. By using this geometric notion, we study the strong and weak convergence of the Ishikawa iterative scheme for noncyclic relatively nonexpansive mappings in uniformly convex Banach spaces. We also establish a best proximity pair theorem for noncyclic contraction type mappings in the setting of strictly convex Banach spaces.
Towards a Model of Olympic Social Capital: Theory and Early Evidence
Authors: Prüschenk Nathalie , Kurscheidt Markus 
Published: February 2020

Towards a model of Olympic social capital: Theory and early evidence Social capital in sports has become an increasingly studied topic. In particular, it has been argued that social capital is created by value-based cultural practices and social exchanges with respect to sport participation and sporting events. However, empirical evidence is scarce and does not capture causal relationships in the process of social capital creation. A general criticism in the social capital literature is that the existing theory falls short of modelling causalities in more detail. Therefore, this paper attempts to develop a causal model of social capital formation within the Olympic movement. It is an exemplary case because of the global esteem of the Olympic Games and their value foundation in Olympism. The worldwide awareness of the Olympics moreover creates social capital among spectators. However, the process of how the perception of Olympic values by spectators is transformed into Olympic social capital is not well understood. Thus, the theoretical modelling focuses on the so-called bridging capital accumulated by Olympic spectators. It is reasoned that the interrelationship of the three Olympic key values of respect, friendship and excellence is perceived and adopted by live spectators via a cyclic process of simultaneous experience resulting in a sustainable episodic memory. In contrast, broadcast spectators develop a dichotomous semantic memory, more influenced by socio-economic tensions caused by the commodification of the Olympic value of excellence. Hence, the live Olympic capital tends to be larger than the broadcast Olympic capital. The plausibility of the model’s propositions is illustrated by data from a cluster sample (N=1,703) of German broadcast spectators of and visitors to the 2016 Summer Olympics and 2016 Winter Youth Olympic Games. The basic proposition of the larger live Olympic capital is confirmed, while the evidence for the emotional exposure and socio-economic environment when experiencing the event is mixed.