bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bonobo personality predicts friendship
Authors: Verspeek Jonas , Staes Nicky , Leeuwen Edwin J. C. van , Eens Marcel , Stevens Jeroen M. G. 
Published: December 2019

AbstractIn bonobos, strong bonds have been documented between unrelated females and between mothers and their adult sons, which can have important fitness benefits. Often age, sex or kinship similarity have been used to explain social bond strength variation. Recent studies in other species also stress the importance of personality, but this relationship remains to be investigated in bonobos. We used behavioral observations on 39 adult and adolescent bonobos housed in 5 European zoos to study the role of personality similarity in dyadic relationship quality. Dimension reduction analyses on individual and dyadic behavioral scores revealed multidimensional personality (Sociability, Openness, Boldness, Activity) and relationship quality components (value, compatibility). We show that, aside from relatedness and sex combination of the dyad, relationship quality is also associated with personality similarity of both partners. While similarity in Sociability resulted in higher relationship values, lower relationship compatibility was found between bonobos with similar Activity scores. The results of this study expand our understanding of the mechanisms underlying social bond formation in anthropoid apes. In addition, we suggest that future studies in closely related species like chimpanzees should implement identical methods for assessing bond strength to shed further light on the evolution of this phenomenon.
Real-time PCR for direct aptamer quantification on functionalized graphene surfaces
Authors: dos Santos Viviane C. F. , Almeida Nathalie B. F. , de Sousa Thiago A. S. L. , Araujo Eduardo N. D. , de Andrade Antero S. R. , Plentz Flávio 
Published: December 2019

AbstractIn this study, we develop a real-time PCR strategy to directly detect and quantify DNA aptamers on functionalized graphene surfaces using a Staphylococcus aureus aptamer (SA20) as demonstration case. We show that real-time PCR allowed aptamer quantification in the range of 0.05 fg to 2.5 ng. Using this quantitative technique, it was possible to determine that graphene functionalization with amino modified SA20 (preceded by a graphene surface modification with thionine) was much more efficient than the process using SA20 with a pyrene modification. We also demonstrated that the functionalization methods investigated were selective to graphene as compared to bare silicon dioxide surfaces. The precise quantification of aptamers immobilized on graphene surface was performed for the first time by molecular biology techniques, introducing a novel methodology of wide application.
System OMICs analysis of Mycobacterium tuberculosis Beijing B0/W148 cluster
Authors: Bespyatykh Julia , Shitikov Egor , Guliaev Andrei , Smolyakov Alexander , Klimina Ksenia , Veselovsky Vladimir , Malakhova Maya , Arapidi Georgij , Dogonadze Marine , Manicheva Olga , Bespiatykh Dmitry , Mokrousov Igor , Zhuravlev Viacheslav , Ilina Elena , Govorun Vadim 
Published: December 2019

AbstractMycobacterium tuberculosis Beijing B0/W148 is one of the most widely distributed clusters in the Russian Federation and in some countries of the former Soviet Union. Recent studies have improved our understanding of the reasons for the “success” of the cluster but this area remains incompletely studied. Here, we focused on the system omics analysis of the RUS_B0 strain belonging to the Beijing B0/W148 cluster. Completed genome sequence of RUS_B0 (CP030093.1) and a collection of WGS for 394 cluster strains were used to describe the main genetic features of the population. In turn, proteome and transcriptome studies allowed to confirm the genomic data and to identify a number of finds that have not previously been described. Our results demonstrated that expression of the whiB6 which contains cluster-specific polymorphism (a151c) increased almost 40 times in RUS_B0. Additionally, the level of ethA transcripts in RUS_B0 was increased by more than 7 times compared to the H37Rv. Start sites for 10 genes were corrected based on the combination of proteomic and transcriptomic data. Additionally, based on the omics approach, we identified 5 new genes. In summary, our analysis allowed us to summarize the available results and also to obtain fundamentally new data.
An ecohydrological approach to the river contamination by PCDDs, PCDFs and dl-PCBs – concentrations, distribution and removal using phytoremediation techniques
Authors: Urbaniak M. , Kiedrzyńska E. , Wyrwicka A. , Zieliński M. , Mierzejewska E. , Kiedrzyński M. , Kannan K. , Zalewski M. 
Published: December 2019

AbstractThe levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in the Pilica River and Sulejów Reservoir were found to be 46% higher during the flood season than during stable flow periods. In addition, PCDD/PCDF and dl-PCB mass loads increased by 5- to 12-fold and by 23- to 60-fold for toxic equivalency (TEQ) during flooding. The Sulejów Reservoir was found to play a positive role in reducing PCDD, PCDF and dl-PCB transport within the study period, with reductions ranging from 17 to 83% for total concentrations, and 33 to 79% for TEQ. Wastewater Treatment Plants (WTPs) were not efficient at mass concentration removal, with small displaying the least efficiency. WTPs discharge pollutants into the aquatic environment, they also produce sludge that requires disposal, similar to reservoir sediments. Sludge- or sediment-born PCDDs, PCDFs and dl-PCBs may be removed using phytoremediation. The cultivation of cucumber and zucchini, two efficient phytoremediators of organic pollutants, on polluted substrate resulted in a mean decrease in PCDD + PCDF + dl-PCB TEQ concentrations: 64% for cucumber and 69% for zucchini in sludge-amended soil, and by 52% for cucumber and 51% for zucchini in sediment-amended soil.
Die Entdeckung des AV-Knotens des Herzens durch Sunao Tawara und Ludwig Aschoff
Authors: Aumüller Gerhard 
Published: December 2019

AbstractAlready in 1664, the Danish anatomist and naturalist Niels Stensen proved that the heart is a muscle. But for a long time it remained unclear what triggered the heart contractions.The Dutch physiologist Willem Einthoven registered the electrical processes in the contraction of the heart muscle and thus provided the first electrophysiological basis of cardiac muscle activity. Since 1903, Sunao Tawara was assistant to Ludwig Aschoff in Marburg. Both left Marburg in 1906: Tawara went back to Japan and Aschoff to Freiburg. In 1905, Tawara discovered the connections of the His’ bundle to the AV node and the Purkinje fibers. At that time, there was no thought of a functional interpretation. Tawara discovered a kind of “knot” that linked to the adjacent myocardial cells, as well as the “Tawara thighs”, which frayed and went into structures known as Purkinje fibers. Tawara detected the tree-like structure he had discovered as a muscle-fiber system that controlled the arousal of the heart’s musculature. Thus the old dispute between myogenic and neurogenic arousal of the heart was decided in favor of the myogenic excitation conduction. The atrioventricular node described by Tawara was given the eponym “Aschoff-Tawara node”. Tawara’s groundbreaking work on the conduction system was the basis for the discovery of the sinus node and the interpretation of the heart’s electrophysiology.
Berechenbarkeit der Qualitätsindikatoren der onkologischen S3-Leitlinien mit dem ADT-/GEKID-Basisdatensatz und seiner Zusatzmodule
Authors: Gebauer Alexander , Barlag Hagen , Wesselmann Simone , Biedenweg Linda , Weitmann Kerstin , Klinkhammer-Schalke Monika , Hoffmann Wolfgang 
Published: December 2019

Zusammenfassung
Hintergrund Das Krebsfrüherkennungs- und -registergesetz (KFRG, § 65c SGB V) regelt zur Verbesserung der onkologischen Versorgung, dass die klinische Krebsregistrierung in Deutschland auf Grundlage des Basisdatensatzes der Arbeitsgemeinschaft Deutscher Tumorzentren (ADT) und der Gesellschaft der epidemiologischen Krebsregister in Deutschland (GEKID) durchzuführen ist. Qualitätsindikatoren in S3-Leitlinien sind Kennzahlen zur Beurteilung der Qualität von Behandlung und Ergebnis in der klinischen Versorgung für die jeweilige Krebsentität. Diese Studie untersucht, in welchem Umfang diese Qualitätsindikatoren anhand der Variablen des ADT/GEKID Basisdatensatzes und seiner organspezifischen Module berechnet werden können.
Methoden Nach Überprüfung aller verfügbaren S3-Leitlinien auf die Ein- und Ausschlusskriterien zur Berechnung der Qualitätsindikatoren, wurde für jeden Indikator bewertet, ob er unter Verwendung einer einzelnen oder einer Kombination mehrerer Variablen des ADT/GEKID Basisdatensatzes und seiner organ-spezifische Module berechnet werden kann.
Ergebnisse In 17 veröffentlichten S3-Leitlinien werden insgesamt 151 Qualitätsindikatoren definiert. Davon können 82 (54%) Qualitätsindikatoren mit den Variablen des ADT/GEKID Basisdatensatzes ermittelt werden. Nur die Qualitätsindikatoren des exokrinen Pankreaskarzinoms konnten zu 100% berechnet werden und hatte damit den höchsten berechenbaren Anteil. Der geringste Anteil an Qualitätsindikatoren ist für das Mundhöhlenkarzinom berechenbar (10%).
Schlussfolgerungen Diese Analyse zeigt erhebliche Unterschiede bei der Berechenbarkeit der Qualitätsindikatoren für die verschiedenen Tumorentitäten mittels der in den klinischen Krebsregistern dokumentierten Variablen. Der ADT/GEKID-Basisdatensatz sollte um zusätzliche organ-spezifische Module, ähnlich dem Modul für das kolorektale Karzinom, erweitert werden, um eine möglichst vollständige Dokumentation aller Variablen zu ermöglichen, die für die Bestimmung der klinischen Qualitätsindikatoren erforderlich sind.
The impact of mild cognitive impairment on musical ability
Authors: Agren Carolin , Frese Achim , Summ Oliver , Evers Stefan 
Published: December 2019

ZUSAMMENFASSUNG
Hintergrund: Patienten mit einer Alzheimer-Erkrankung zeigen Beeinträchtigungen kognitiver Prozesse einschließlich der Verarbeitung musikalischer Reize. Wir haben untersucht, ob der Rückgang der musikalischen Verarbeitung schon im Stadium der mild cognitive impairment (MCI) beginnt.
Methodik: Wir haben 18 Patienten mit MCI und ohne eine andere neurologische oder psychiatrische Erkrankung eingeschlossen. Es wurde ein selbst entwickelter Musikalitätstest angewendet, der folgende Fähigkeiten misst: Identifikation von Melodien; Tonhöhenerkennung; Rhythmuserkennung; emotionaler Ausdruck der Musik. Zusätzlich haben wir Marker einer dementiellen Entwicklung im Liquor bestimmt. Wir haben die Ergebnisse der Patienten verglichen mit den Ergebnissen einer nach Alter und Geschlecht parallelisierten gesunden Vergleichsgruppe. Alle Patienten und Kontrollen hatten keine spezifische musikalische Ausbildung.
Ergebnisse: Patienten mit MCI zeigten signifikant niedrigere Ergebnisse beim Rhythmus, Metrum und emotionalen Subtests und im gesamten Test-Score. Der Gesamt-Score war invers korreliert mit dem Level von Gesamt-Tau im Liquor.
Diskussion: Unsere Daten deuten darauf hin, dass einige Domänen der Musikalität bei Patienten mit MCI signifikant beeinträchtigt sind. Dies bedeutet jedoch nicht notwendigerweise, dass die Produktion von und die Freude an Musik beeinträchtigt sind. Dennoch sollte die Beeinträchtigung von Teilen der Musikalität beim Einsatz von Musiktherapie bei diesen Patienten berücksichtigt werden.
Neuro-Ophthalmologic Complications of Giant Cell Arteritis: Diagnosis and Treatment
Authors: Fein Alexander S. , Ko Melissa W. 
Published: December 2019

AbstractGiant cell arteritis (GCA) is the most common vasculitis in individuals 50 years or older, with a lifetime risk in the United States of 1% in women and 0.5% in men. It is a granulomatous disease that affects large- and medium-sized vessels, most notably the branches of the internal and external carotid arteries. GCA can cause both afferent and efferent visual manifestations, the most common being arteritic anterior ischemic optic neuropathy. Diagnosis of GCA is made using criteria developed by the American College of Rheumatology, which include clinical signs, positive biopsy, and elevated erythrocyte sedimentation rate. C-reactive protein and platelet counts may be elevated in GCA, and noninvasive imaging modalities such as Doppler ultrasound and magnetic resonance imaging are now being used to aid in diagnosis. While glucocorticoids are the mainstay of treatment for GCA, new breakthrough treatments such as tocilizumab (an anti-IL-6 receptor antibody) have shown great promise in causing disease remission and reducing the cumulative glucocorticoid dose. Emerging therapies such as abatacept and ustekinumab are still being studied and may be of use to clinicians in the future.
Cobertura del Dorso de los Dedos de la Mano Con Colgajos Tipo Propeller de Perforantes de Arteria Intermetacarpiana Dorsal
Authors: Vela-Lasagabaster Arturo , De Juan-Huelves Ana , Gutiérrez-Roca Laura 
Published: December 2019

ResumenLas lesiones en el dorso los dedos de la mano, debidas a traumatismos, infecciones o quemaduras, son causa frecuente de exposición de estructuras nobles óseas, articulares y/o tendinosas. El dorso de la mano ofrece la posibilidad de cobertura donante con una gran similitud de calidad de tejido. Por ello, una opción sencilla y práctica es la cobertura con un colgajo tipo Propeller de perforantes de la arteria intermetacarpiana dorsal, conocido en la literatura médica anglosajona como “Quaba flap,” y sus variantes. Presentamos una serie de 3 pacientes, con afectación y exposición noble del dorso de los dedos, desde F1, PIP Y F2, ocurridos tras infección, quemadura y traumatismo, respectivamente, que se vieron beneficiados de esa técnica, empleando, en cada caso, un colgajo de distinto espacio intermetacarpiano dorsal. Especificamos los detalles de la técnica quirúrgica con referencias anatómicas.
Kisspeptin as a Behavioral Hormone
Authors: Mills Edouard G.A. , O'Byrne Kevin T. , Comninos Alexander N. 
Published: December 2019

AbstractSuccessful reproduction is dependent not only on hormonal endocrine responses but also on suitable partner selection, copulatory acts, as well as associated emotional, behavioral, and cognitive processes many of which are supported by the limbic system. The reproductive hormone kisspeptin (encoded by the KISS1/kiss1 gene) is now recognized as the key orchestrator of the reproductive axis. In addition to the hypothalamus, prominent kisspeptin neuronal populations have been identified throughout limbic and paralimbic brain regions across an assortment of species. In this review, we detail the emerging roles of kisspeptin signaling in the broader aspects of behavioral, emotional, and cognitive control. Recent studies from zebrafish through humans have provided new molecular and neural insights into the complex role of kisspeptin in interpreting olfactory and auditory cues to govern sexual partner preference, in regulating copulatory behaviors and in influencing mood and emotions. Furthermore, emerging roles for kisspeptin in facilitating memory and learning are also discussed. To this end, these findings shed new light onto the importance of kisspeptin signaling, while informing the pharmacological development of kisspeptin as a potential therapeutic strategy for individuals suffering from associated reproductive, emotional, and cognitive disorders.
Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans?
Authors: Lehman Michael N. , He Wen , Coolen Lique M. , Levine Jon E. , Goodman Robert L. 
Published: December 2019

AbstractThere is now considerable evidence supporting the role of a subpopulation of neurons in the arcuate nucleus of the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin (abbreviated as KNDy neurons) as the long sought-after gonadotropin-releasing hormone (GnRH) pulse generator. The “KNDy hypothesis” of pulse generation has largely been based on findings in rodents and ruminants, and there is considerably less information about the anatomical and functional organization of the KNDy subpopulation in the primate hypothalamus. In this review, we focus on the applicability of this hypothesis, and the roles of kisspeptin, neurokinin B, and dynorphin in reproduction, to humans and nonhuman primates, reviewing available data and pointing out important gaps in our current knowledge. With recent application of drugs that target KNDy peptides and their receptors to therapeutic treatments for reproductive disorders, it is imperative we fully understand the primate KNDy network and its role in the control of GnRH secretion, as well as species differences in this system that may exist between humans, nonhuman primates, and other mammals.
The Roles of the Amygdala Kisspeptin System
Authors: Mills Edouard G. A. , O'Byrne Kevin T. , Comninos Alexander N. 
Published: December 2019

AbstractThe hypothalamic hormone kisspeptin (encoded by the KISS1/kiss1 gene) is the master regulator of the reproductive axis with its role in controlling gonadotrophin hormone secretion now well characterized. However, identification of kisspeptin and its cognate receptor expression within the amygdala, a key limbic brain region whose functions contribute to a broad range of physiological and behavioral processes, has heightened interest concerning kisspeptins' role in the broader aspects of reproductive physiology. In this review, we detail the important developments and key studies examining the emerging functions of this kisspeptin population. These studies provide novel advances in our understanding of the mechanisms controlling reproductive neuroendocrinology by defining the crucial role of the amygdala kisspeptin system in modulating pubertal timing, reproductive hormone secretion, and pulsatility, as well as its influence in governing-related behaviors. To this end, the role of the amygdala kisspeptin system in integrating reproductive hormone secretion with behavior sheds new light onto the potential use of kisspeptin-based therapeutics for reproductive and related psychosexual disorders.
Breakfast can Affect Routine Hematology and Coagulation Laboratory Testing: An Evaluation on Behalf of COLABIOCLI WG-PRE-LATAM
Authors: Arredondo Maria Elena , Aranda Eduardo , Astorga Rubén , Brennan-Bourdon Lorena Michele , Campelo Marise Danielle , Flores Silvia , Medel Claudio , Manríquez Ignacio , Ochoa Patricia , Varela Beatriz , Salinas Carlos Vega , Lima-Oliveira Gabriel 
Published: December 2019

AbstractLaboratories worldwide perform both hematological and coagulation testing on patients avoiding fasting time. In 2017, the Latin America Confederation of Clinical Biochemistry (COLABIOCLI) commissioned the Latin American Working Group for Preanalytical Phase (WG-PRE-LATAM) to study preanalytical variability and establish guidelines for preanalytical procedures to be applied by clinical laboratories and health care professionals. This study, on behalf of COLABIOCLI WG-PRE-LATAM, aims to evaluate the effect of the breakfast on routine hematology and coagulation laboratory testing. We studied 20 healthy volunteers who consumed a breakfast containing a standardized amount of carbohydrates, proteins, and lipids. We collected blood specimens for routine hematology and coagulation laboratory testing before breakfast and 1, 2, and 4 hours thereafter. Significant differences between samples were assessed by the Wilcoxon ranked-pairs test. Statistically significant differences (p < 0.05) between basal and 4 hours after the breakfast were observed for red blood cells, hemoglobin, hematocrit, mean corpuscular volume, white blood cells, neutrophils, lymphocytes, monocytes, mean platelet volume, and activated partial thromboplastin time. In conclusion, the significant variations observed in several hematological parameters, and activated partial thromboplastin time due to breakfast feeding demonstrate that the fasting time needs to be carefully considered prior to performing routine hematological and coagulation testing to avoid interpretive mistakes of test results, and to guarantee patient safety. Therefore, COLABIOCLI WG-PRE-LATAM encourages laboratory quality managers to standardize the fasting requirements in their laboratory, i.e., 12 hours.
A New Catheter Technique to Correct Severe IVC Filter Tilt during Placement
Authors: Laroia Sandeep T. , Guan Justin J. , Laroia Archana T. , Lenhart Lucas , Hayes Antony J. 
Published: December 2019

Abstract
Introduction Inferior vena cava (IVC) filter tilt is a common complication that occurs during and after filter placement. Severe tilting leads to reduced filter efficacy, lower retrieval success, and higher complication rates during retrieval. We present a novel catheter technique to correct severely tilted cone-shaped IVC filters without having to retrieve and replace the existing filter.
Methods A retrospective review was performed for patients at our institution over three years who had severely tilted filters and underwent correction with the catheter technique. Indications for filter placement were categorized, and patient age, gender, tilt correction outcome, and complication rates were collected and analyzed. After severe tilting was noted on post-IVC filter deployment venogram, a Sos catheter was passed via the same femoral access site used for the filter placement. The catheter tip was reformed inside the cone of the filter and was used to push the filter tip back toward midline. Completion venogram was taken to document the amelioration of the tilt.
Results Out of 28 patients who were found to have severely tilted filters on deployment and underwent correction with the catheter technique, 27/28 (96.4%) had successful correction. One (3.6%) had a minor complication where the filter struts became entangled with the catheter tip; however, simple maneuvering of the catheter and use of a stiff wire to straighten the catheter loop freed up the entanglement. No major complications occurred.
Conclusion This technique is safe, effective, obviates filter replacement, and can be considered an additional management option for severe IVC filter tilt during placement.
What’s in a name? Measuring access to social activities with a field experiment
Authors: Nesseler Cornel , Gomez-Gonzalez Carlos , Dietl Helmut 
Published: December 2019

AbstractToday’s societies increasingly consist of members who migrated from other countries and regions, and their functioning depends heavily on integrating their diverse members. Interactions with the local population through social activities enhance integration. Despite its relevance, however, previous research has largely overlooked the role of the local population in social integration. This paper introduces an objective method for analyzing access to social activities. Switzerland includes diverse native groups, who differ in culture and language, and a high percentage of foreigners. Applications were sent by email to amateur Swiss football clubs, asking if it is possible to join a training session. The applications differed only in the contact name. Individuals with foreign names, as well as individuals with Swiss names from some other native groups, received significantly fewer responses. The findings are relevant for governing institutions and policy-makers. Researchers who study social integration may find the novel method used here of considerable interest.