bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung-heart pressure index is a risk factor for acute respiratory distress syndrome (ARDS): A machine learning and propensity score-matching study.
Authors: Yu Xue-Shu , Pan Xiao-Jun , Chen Zhi-Qiang , Hu Yu-Feng , Shu Jie , Xu Shun-Yao , Zhang Xian-Wei , Jiang Hao , Chen Wen-Jing , Ye Yin-Cai , Pan Jingye 
Published: December 2019

Abstract
Background Ventilator-induced lung injury (VILI) and haemodynamic instability play vital roles in acute respiratory distress syndrome (ARDS). The principle of driving pressure (DP) is the response to “volutrauma”, and the mean arterial pressure (MAP) is a haemodynamic systemic manifestation. In this study, we explored a novel lung-heart pressure index (LHPI) based on DP and MAP and explored its prognostic value in patients with ARDS.Methods This is a retrospective study based on the MIMIC-III database. ARDS patients who had undergone mechanical ventilation for more than 48 hours were selected through structured query language. The focus of the study was whether a high LHPI was associated with 30-day mortality and whether its predictive power was better than that of DP and mechanical power (MP). We used random forest, propensity-score matching, and logistic regression to test our hypothesis.Results A total of 448 ICU ARDS patients were enrolled. The mortality rate of ARDS patients was 29.02%. The LHPI was more important than DP and MP in the random forest. A significant adverse effect of high LHPI on 30-day mortality was observed in the high-LHPI group compared to the effect observed in the low-LHPI group (OR=1.86, 95% CI 1.08–3.26, p =0.027). More importantly, LHPI was significantly better than DP (NRI=0.054, 95% CI (0.014-0.094), P=0.008; IDI=0.011, 95% CI (0.002-0.019), P=0.014) and MP (NRI=0.061, 95% CI (0.001-0.122), P=0.049; IDI=0.047, 95% CI (0.022-0.071), P<0.001) in predicting mortality.Conclusions The study showed that the LHPI was a powerful prognostic indicator of 30-day mortality in ARDS patients, and its predictive discrimination was better than that of DP and MP. Further experimental trials are needed to investigate whether adjusting treatment decisions according to the LHPI will significantly improve clinical outcomes.
Image quality in telehealth: challenges in developing countries
Authors: Chowdhury Avijit , Hafeez-Baig Abdul , Gururajan Raj , McCubbin Amanda , Sharif Mirza Akmal 
Published: December 2019

Abstract
The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional. An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diagnosis and treatment. This cross-sectional qualitative study used semi-structured interviews with healthcare professionals in both India and Pakistan. The interviews were analyzed using a thematic analysis, which revealed three major themes. These themes being: ICT infrastructure and connectivity, high-quality images were produced by trained technicians in an organized telemedicine set-up; and image quality can be degraded by multiple transmissions. Findings indicate that in both countries the main underlying challenge is the lack of consistency in the network infrastructure between urban, rural and remote areas. Additionally, training patients to use hand-held devices to take high-quality images future could hold the key to improving the reliability and consequently the quality of images transmitted between patients and health care professionals.
ToxoGRA15II promote macrophages polarization against Hepatic carcinoma by targeting TRAF6
Authors: Cai Yihong , Yu Yanxia , Wang Yanling , Zhang Yuan , Yu Li , Sheng Jilong 
Published: December 2019

Abstract
Background: There is increasing evidence that tumor-associated macrophages play an important role in the development of tumors. The more macrophages, the faster the tumors develop. On the one hand, studies have shown that the dense granule protein molecule of Toxoplasma gondii (ToxoGRA15II) tends to induce the differentiation of classically activated macrophages (M1). GRA15II can also induce M2 reversal polarized to M1. Promote the occurrence of Th1 immune response.Methods: Here, we constructed LV-gra15Ⅱ, which was transferred to M1-like and/or M2-like macrophages. Furthermore, we injected LV-gra15Ⅱ by vein into tumor bearing C57BL/6 mice.Results: We found that M2-like macrophages could be polarized to M1-like macrophages, inducing NO, IL12, TNF-αexpression. Mechanistically, ToxoGRA15Ⅱ activate NF-κB signaling pathway by binding to TRAF6. Additionally, LV-gra15Ⅱ promoted p65 nuclear translocation to polarize TAM to M1-like macrophages and induce IFN-γ,TNF-α,IL12, NO expression, inhibiting tumor growth. Subsequently, ToxoGRA15Ⅱ has a role in cancer pathway and metabolism.Conclusions: Taken together, these findings could lead to the development of immunotherapy strategies to tumor, due to ToxoGRA15Ⅱ as polypeptide effector molecule of T.gondii and non-toxicity to mammalians.
Identifying Potential Markers for Monitoring Progression to Ovarian Cancer Using Plasma Label-free Proteomics
Authors: Wang Wenjie , Xie Hongyu , Xia Bairong , Zhang LiuChao , Wang Ce , li kang , Hou Yan 
Published: December 2019

Abstract
PurposeCancer antigen 125 (CA125) is considered to have high sensitivity but poor specificity for ovarian cancer. New biomarkers utilized to early detect and monitor the progression of ovarian cancer patients are critically needed. Methods A total of 80 patients including 16 early stage, and matched with 17 late stage, 23 benign ovarian tumor (BOT) and 24 uterine fibroid (UF) patients were utilized to perform plasma proteomics analysis using isobaric tag for relative and absolute quantitation (iTRAQ) method to identify differential diagnostic proteins of ovarian cancer patients. A validation set of 9 early stage, 11 late stage, 17 BOT and 16 UF collected by an independent cohort of samples with the same matching principles was examined to confirm the expressed levels of differential expression proteins by ELISA analysis. Results CRP and ARHGEF 11 were identified as potential diagnostic biomarkers of ovarian cancer. Results of area under the curve (AUC) analysis suggested that combination of diagnostic proteins and CA125 achieved a much higher diagnostic accuracy compared with CA125 alone (AUC values: 0.98 versus 0.80), especially improved the specificity (0.97 versus 0.77). In addition, elevated plasma CRP levels were associated with increased risk of ovarian cancer. Conclusions Current study found that plasma protein CRP was an indicator for monitoring the progression of ovarian cancer. Combination of plasma protein biomarkers with CA125 could be utilized to early diagnose of ovarian cancer patients. Keywords ovarian cancer, proteomics, diagnosis, progression, CRP
LncRNA NCRNA00173 is down-regulated in pediatric osteosarcoma and suppresses cell metastasis of osteosarcoma cells through regulating PI3k/Akt pathway
Authors: Zhao Zhongquan , Chen Jiechao , Xia Dezhi 
Published: December 2019

Abstract
Background: Osteosarcoma (OS) is a primary malignant tumor with high mortality and disability rate in childhood and adolescent, whereas the influence of LncRNA00173 (NCRNA00173) on pediatric OS progression is not obvious yet. Therefore, this study aimed to investigate the expression of NCRNA00173 in pediatric OS and its effect on OS progression. Methods: In our study, qRT-PCR was adopted to test the NCRNA00173 expression in 40 pairs of pediatric OS tissues and OS cell lines. Kaplan-Meier method and Cox proportional hazard model were performed to analyze the prognosis of pediatric OS patients. The cell proliferation, apoptosis, migration and invasion of U2OS and HOS cells were test by MTT assay, flow cytometry, wound-healing, and transwell assay, respectively. The protein expression levels of PI3K/Akt pathway were measured by western blot. In addition, tumor growth in nude mice was also detected. Results: The expression of NCRNA00173 was down-regulated and relevant with poor prognosis in pediatric OS. Overexpression of NCRNA00713 inhibited cell proliferation, migration and invasion, as well as accelerated cell apoptosis in U2OS and HOS cells. Overexpression of NCRNA00713 suppressed tumor growth in nude mice. The protein expression of p-PI3K and p-Akt were remarkedly decreased in U2OS and HOS cells after transfection with NCRNA00173. In addition, 740 Y-P (PI3K/Akt pathway activator) eliminated the impact of NCRNA00173 in HOS. Conclusions: NCRNA00173 was down-regulated in pediatric OS and suppressed metastasis of OS cells by regulating PI3k/Akt pathway.
Evaluation of VEGFA gene variants for possible roles in cerebral infarction diseases
Authors: Zhang Qiong , Guo Man , Xu Chao , Lei Hong , Zhou Jie , Zhu Chun-Yu , Li Fei-feng , Liu Shu-Lin 
Published: December 2019

Abstract
Background: Cerebral infarction is one of the most common cerebral small vessel diseases. Many angiogenesis relevanted factors have special roles on the diseases pathogenesis. The vascular endothelial growth factor A (VEGFA) is the most prominent stimulating molecule factor for angiogenesis. So, we want to evaluate the correlation between VEGFA gene and this disease in this work. Methods: The VEGFA gene was sequenced for 400 cerebral infarction patients and 600 normal controls. SPSS software (version 19.0), Plink (version 1.9), Haploview software and online software SNPSpD were used for the statistical analyses and Hardy-Weinberg equilibrium tests. Results: We found variants rs10434, rs3025040, rs185218985, rs199971699, rs574579489, rs735286 and rs833061 within or near the VEGFA gene. The genetic heterozygosity of rs10434, rs3025040, rs735286 and rs833061 was very high. Statistical analysis showed that the variants rs10434 (P=0.041) and rs735286 (P=0.034) in the gene were associated with the risk of cerebral infarction diseases in the Chinese Han population. Conclusions: VEGFA variants rs10434 and rs735286 were associated with the risk of cerebral infarction diseases in the Chinese Han population.
Examination of a nationwide cohort of individuals with high health literacy in terms of their health-related lifestyles and attainment of the goals of the “National Health Promotion in the 21st Century” Program
Authors: Hirooka Nobutaka , Sano Takeshi , Yasumura Reiko , Maeyama Yuji , Nakamoto Hidetomo 
Published: December 2019

Abstract
Background: In Japan, where the population is aging particularly rapidly, “healthy aging” is being advocated as a means of addressing the potential societal burdens caused by older adults’ need for nursing care and the high associated health-care costs. To improve healthy aging among the population, the Japanese government has launched the “National Health Promotion in the 21st Century” (HJ21), which contains goals concerning areas such as lifestyle behavior and use of preventive medicine. Low health literacy is associated with many health-related issues; however, whether individuals with high health literacy are meeting the HJ21 goals has not yet been examined. This study aims to determine whether a cohort with high health literacy are meeting such goals, and to compare the cohort’s performance with the national average. Methods: This is a cross-sectional survey study. Study participants, sourced from all prefectures in Japan, were professional specialists in health management certified by the Japanese Association of Preventive Medicine for Adult Disease. We measured data concerning the cohort’s demographic information, health perception, lifestyle (including physical activity) and use of preventive medicine. Results: The cohort showed many characteristics of high health literacy. The cohort had an overall healthy lifestyle and met most of the HJ21 goals; in particular, a high proportion underwent health-maintenance exams and cancer screenings. Conclusions: The high health literacy cohort showed a healthy lifestyle. Compared to the national average, a higher proportion of the cohort met the HJ21 goals and received preventive medicine.
A Study of Internet Addiction and Its Effects on the Mental Health of Medical Students: A Cross-Sectional Study in Western Iran
Authors: Lebni Javad Yoosefi , Toghroli Razie , Sharma Manoj , Mahaki Behzad , Gilan Hadi Darvishi , Kianipour Neda , Chaboksavar Fakhreddin , Moradi Farideh , Ziapour Arash 
Published: December 2019

Abstract
Background: The internet itself is a harmless technology. However, its overuse and misuse will expose its users to internet addiction. On the other hand, diagnosis of students’mental dysfunction is of prime importance, and their progress and academic success in the future can be prevented by this technology if not properly handled. Methods: In this descriptive and correlational study, the statistical population consisted of all students at Kermanshah University of Medical Sciences, of which 447 students studying in the first and second semesters of the academic year 2017-18 were selected through Cochran's Sample Size Formula and Stratified Random Sampling. As for data collection, the Young's Internet addiction Test (IAT) and Goldberg General Health Questionnaire (GHQ-28) were utilized. Moreover, for data analysis, the descriptive statistics (percentage, mean, standard deviation) and inferential statistics (T-test, Pearson correlation coefficient, and multiple regression analysis) were employed in the environment of SPSS Statistical Software Version 23.0. Results: The results of the present study demonstrated that the total mean score of students’ internet addiction and mental health measured 3.81±0.88 and 2.56±0.33, respectively. The results also indicated that internet addiction correlared positively with depression whereas negatively with mental health (P<0.001). Besides, the results of multiple regression analysis revealed that the five major predictors of vulnerability to internet addictionin university students were as follows: the key reason for using the internet, faculty, depression, the main place for using the internet, and somatic symptoms. Conclusions: According to the findings of the present study, it can be concluded that students’ excessive use of the internet leads to depression, anxiety, and reduced mental health, thereby affecting their academic performance. Hence, it is suggested that further monitoring and control be exercised on how the internet is used by university students, and they should be informed of the detrimental effects of this technology in the case of misuse or overuse.
Prevalence and Associated Factors of Thinness among Adolescent Students in Finoteselam Town, Amhara Region, Ethiopia
Authors: Mengesha Damitie Kebede , Prasad Reddy P. C. J. , Asres Degnet Teferi 
Published: December 2019

Abstract
Background Adolescence is the period of intense physical, psychosocial and cognitive development and the second to infancy at which highest rate of physical growth occur. So, adolescents need to have good quantity and quality nutrient to cope with this rapid growth and other health risk which increase nutritional demand. This study aimed to assess the prevalence and associated factors of thinness among school adolescents in Finoteselam town, Amhara region, Ethiopia.Methods A school-based cross-sectional study among adolescent students aged 10-19 in public primary and secondary schools was carried out in Finoteselam town from February 05 to March 27, 2018. A total of 397 adolescent students were included in the study. Stratified and simple random sampling techniques were employed to select study subjects. Pre tested structured questionnaires were used to collect the data. Data was entered using Epi info version 7 and analyzed using SPSS version 20 and WHO Anthro Plus soft ware. A multivariate logistic regression analysis was employed to identify factors associated with stunting. Crude and adjusted odds ratios with 95% level significance were used to measure the strength of association and statistical significance was declared at p-value less than 0.05.Results The prevalence of thinness among adolescents was 14.9%. Early Adolescent stage (AOR= 4.81; 95% CI: 1.23, 18.51), being Male adolescent students (AOR = 2.33; 95% CI: 1.60, 3.40), and using well water (AOR= 3.82; 95% CI: 1.46, 10.04) were significantly associated with thinness at P-value <0.05.Conclusion The study revealed that prevalence of thinness was high in the study area. Age, Sex and sources of drinking water were found to be important factors associated with thinness among the respondents.
Study on the Evolution of Information Sharing Strategy for Users of Medical Cloud
Authors: Zhu Panpan , Shen Jiang , Xu Man 
Published: December 2019

Abstract
Technological advances are driving the growth of online health communities. However, there are some problems such as low user participation and insignificant social benefits in online health communities. This paper discusses the evolution law of information sharing behavior of members of online health community to study the influence of different behaviors on health information sharing results and explore the ways to improve the level of community information sharing. Based on BA scale-free network (Albert-László Barabás and Réka Albert scale-free network) , this paper established an information sharing behavior model for members of online health community with the evolutionary game theory method, and discussed the influence of different game parameters and initial conditions on the evolution results of information sharing behavior of community patients with the method of numerical experiment.Results: It is found that the key to improve the level of community information sharing is to improve the benefit of patients' information sharing, the proportion of patients sharing information at the initial moment, the degree of network nodes, and reduce the sharing cost. Community managers should improve the information conversion ability and information absorption ability of community patients through offline activities, professional guidance and other forms. At the same time, it can reduce the difficulty and risk of information sharing and strengthen the connection among members, thus comprehensively enhancing the value of the community.
PENGEMBANGAN PERANGKAT PERKULIAHAN FISIKA DASAR 1 DINAMIKA GERAK DENGAN PENDEKATAN DEMOCRATIC APPROACH
Authors: Poernomo Joko Budi 
Published: December 2019

Penelitian ini bertujuan mengembangkan bentuk perangkat perkuliahan Fisika dengan democratic approach melalui problem posing pada Dinamika Gerak. Metode pe- nelitian adalah penelitian pengembangan perangkat pem- belajaran yang meliputi Satuan Acara Perkuliahan (SAP) dan Bahan Ajar. Draft perangkat yang dihasilkan divali- dasi oleh Dosen Mitra, Kaprodi, pakar pendidikan Fisika dan diujicobakan pada siswa di Perkuliahan Fisika Dasar 1 Tahun Akademik 2010-2011. Hasil dari penelitian ini menunjukkan bahwa penilaian validitas isi Satuan Acara Perkuliahan para ahli 4,42; yang tergolong valid; penilain terhadap keterlaksanaan perkuliahan oleh observer 4,45; termasuk kategori baik, dan penilain ketuntasan perkulia- han Fisika Dasar 1 mencapai 86 %, serta 88% mahasiswa memberi respon positip.
PENDIDIKAN KARAKTER DAN PENDEKATAN SETS (Science Environment Technology and Society) DALAM PERENCANAAN PEMBELAJARAN SAINS
Authors: L Listyono 
Published: December 2019

<p>Pengertian karakter menurut Pusat Bahasa Depdiknas adalah “bawaan, hati, jiwa, kepribadian, budi pekerti, perilaku, personalitas, sifat, tabiat, temperamen, watak”. Adapun berkara- kter adalah berkepribadian, berperilaku, bersifat, bertabiat, dan berwatak”. Menurut Tadkiroatun Musroh (UNY, 2008), kara- kter mengacu kepada serangkaian sikap (<em>attitudes</em>), perilaku (<em>behaviors)</em>, motivasi (<em>motivations</em>), dan keterampilan (<em>skills)</em>. Karakter berasal dari bahasa Yunani yang berarti “to mark” atau menandai dan memfokuskan bagaimana mengaplikasikan nilai kebaikan dalam bentuk tindakan atau tingkah laku, se- hingga orang yang tidak jujur, kejam, rakus dan perilaku jelek lainnya dikatakan orang berkarakter jelek. Sebaliknya, orang yang perilakunya sesuai dengan kaidah moral disebut dengan berkarakter mulia.</p>
MELATIH KREATIVITAS DAN DAYA NALAR SISWA MELALUI MODEL PEMBELAJARAN RME
Authors: M Mujiasih 
Published: December 2019

Atas dasar ijin dari Kementerian Pendidikan Nasional, maka model pembelajaran Realistic Mathematics Education (RME) telah dilaksanakan di seluruh Indonesia. Di setiap provinsi, telah ditunjuk beberapa sekolah untuk melak- sanakan pembelajaran RME ini. Oleh karena itu, maka mahasiswa Prodi Tadris Matematika perlu disiapkan se- cara dini, dengan pengetahuan tentang model pembela- jaran RME ini, yakni mengetahui sintaks (urutan langkah pembelajaran), dan mampu mempraktikkannya. Dalam pembelajaran matematika di sekolah, ada tiga dimensi utama yang berkaitan dengan pembelajaran matematika di sekolah, yaitu (1) kegunaan matematika dalam kehidu- pan sehari-hari, (2) matematika sebagai alat berpikir, dan (3) matematika sebagai produk budaya manusia. Pembe- lajaran matematika harus mampu mengembangkan ke- mampuan siswa untuk memberikan alasan (reasoning), mengembangkan kreativitas (creativity), daya nalar (think logically), dan pembuktian (proof). Hal ini dapat dicapai me- lalui pembelajaran RME.Jadi, pembelajaran matematika di sekolah perlu dija- dikan sarana untuk melatih dan mengembangkan kreativi- tas siswa dalam kapasitasnya sebagai anggota masyarakat yang kelak akan beraktivitas dengan memerlukan kreativi- tas yang tinggi. Salah satu caranya adalah dengan mener- apkan RME (Realistic Mathematics Education) di sekolah.
Item in dependability: definition and content of the concept
Authors: Netes V. A. 
Published: December 2019

Aim.The paper continues the series of publications that investigate and discuss the essence and definitions of the basic concepts of the dependability theory. It analyzes the basic concept, which is the subject of consideration in dependability, for which the term “item” is usually used. The concept of “dependability” is defined for it, and in general all the terminology of dependability applies to it. The following issues are considered: how to name and define this subject of consideration, what it can be, what can be its constituents. In particular, the relationship between the concepts of “item” and “product” is discussed.Methods.The evolution of definitions of this concept in the Russian and international terminological standards in dependability over the past 30 years is traced. A comparative analysis of other standards and federal laws relating to items of different types is carried out. The viability of two main ways of getting an idea of a concept is considered: illustrative (based on examples) and definitional (by means of sequential definition of some concepts through others).Findings and conclusions.The definition and correct understanding of the concept of “item” is of great importance, as it affects the scope of dependability standards. It is explained why it is necessary to accept that the definitions of the basic concepts cannot be rigorously formalized and are in fact only explanations. It is shown that the definitions of the item in the existing Russian and international standards (GOST 27.002–2015 and IEC 60050-192:2015) have inaccuracies. To eliminate them, improved notes to the definition of an item are proposed. The first note lists the possible types of items: products (parts, assembly units, complexes) and their components; buildings and structures; systems consisting of jointly functioning products and structures and their subsystems. The second note indicates the relationship between the main constituents of the item: hardware, software and people (personnel), and their possible combinations. The paper provides reasons for considering virtual items that play an important role in today’s information and telecommunication technologies and are logically isolated subsystems within the systems that they are part of. Besides that, it points out the deficiencies in the definitions of various items in GOST 18322–2016.