bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations
Authors: Arrant Andrew E. , Roth Jonathan R. , Boyle Nicholas R. , Kashyap Shreya N. , Hoffmann Madelyn Q. , Murchison Charles F. , Ramos Eliana Marisa , Nana Alissa L. , Spina Salvatore , Grinberg Lea T. , Miller Bruce L. , Seeley William W. , Roberson Erik D. 
Published: December 2019

AbstractLoss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenicGRNmutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia inGRNmutation carriers. Progranulin haploinsufficiency may drive frontotemporal dementia pathogenesis by disrupting lysosomal function, as patients withGRNmutations on both alleles develop the lysosomal storage disorder neuronal ceroid lipofuscinosis, and frontotemporal dementia patients withGRNmutations (FTD-GRN) also accumulate lipofuscin. The specific lysosomal deficits caused by progranulin insufficiency remain unclear, but emerging data indicate that progranulin insufficiency may impair lysosomal sphingolipid-metabolizing enzymes. We investigated the effects of progranulin insufficiency on sphingolipid-metabolizing enzymes in the inferior frontal gyrus of FTD-GRNpatients using fluorogenic activity assays, biochemical profiling of enzyme levels and posttranslational modifications, and quantitative neuropathology. Of the enzymes studied, only β-glucocerebrosidase exhibited impairment in FTD-GRNpatients. Brains from FTD-GRNpatients had lower activity than controls, which was associated with lower levels of mature β-glucocerebrosidase protein and accumulation of insoluble, incompletely glycosylated β-glucocerebrosidase. Immunostaining revealed loss of neuronal β-glucocerebrosidase in FTD-GRNpatients. To investigate the effects of progranulin insufficiency on β-glucocerebrosidase outside of the context of neurodegeneration, we investigated β-glucocerebrosidase activity in progranulin-insufficient mice. Brains fromGrn−/−mice had lower β-glucocerebrosidase activity than wild-type littermates, which was corrected by AAV-progranulin gene therapy. These data show that progranulin insufficiency impairs β-glucocerebrosidase activity in the brain. This effect is strongest in neurons and may be caused by impaired β-glucocerebrosidase processing.
Effect of drug-coated balloons in treatment of stenosis of the femoral artery and vein bypass graft not responding to plain old balloon angioplasty: a case report
Authors: Matsuura Sohei , Yamamoto Kota , Akai Takafumi , Isaji Toshihiko , Takayama Toshio , Hoshina Katsuyuki 
Published: December 2019

Abstract
Background
The use of drug-coated balloons (DCBs) with anti-proliferative agents in treating femoropopliteal lesions was approved in Japan in 2017. A better limb salvage rate or amputation-free rate of DCBs relative to plain old balloon angioplasty (POBA) has been reported; however, there is little evidence of the direct effect on intimal hyperplasia (IH).

Case presentation
A 70-year-old man with chronic limb-threatening ischemia and foot gangrene had undergone bypass surgery from the left common femoral artery to the dorsalis pedis artery 2 years earlier. We evaluated the bypass graft using ultrasonography and found stenosis around the proximal anastomotic site, presumably due to IH. POBA was performed every 3 months due to the repeated re-stenosis of the lesion. Since using the DCB, no restenosis has been detected to date (10 months).

Conclusion
DCB might be an effective tool for treating re-stenosis due to IH or vein grafts that do not respond to POBA.
Indian womb — German baby: transnational gestational surrogacy in the film Monsoon Baby (2014)
Authors: Maierhofer Waltraud 
Published: December 2019

AbstractThe filmMonsoon Baby(2014) by Andreas Kleinert sympathetically shows the needs of the German couple seeking parenthood by gestational carrier in India. I argue that it also takes a strong stand against commercial surrogacy abroad because it points out legal issues and—more importantly—shows how surrogacy work can exploit women’s bodies, emotions, mental and physical health and even lives. From a postcolonial perspective, it is also problematic because it contains neo-colonial topoi and attitudes. Surrogacy with foreign intended parents has in the meantime been banned in India, but it may just move to other countries.Monsoon Babyremains an important contribution to the public debate about reproductive rights and choices as well as global reproductive justice.
Gaze collaboration patterns of successful and unsuccessful programming pairs using cross-recurrence quantification analysis
Authors: Villamor Maureen M. , Rodrigo Ma. Mercedes T. 
Published: December 2019

AbstractA dual eye tracking experiment was performed on pairs of novice programmers as they traced and debugged fragments of code. These programming pairs were categorized into successful and unsuccessful pairs based on their debugging scores. Cross-recurrence quantification analysis (CRQA), an analysis using cross-recurrence plots (CRP), was used to determine whether there are significant differences in the gaze collaboration patterns between these pair categories. Results showed that successful and unsuccessful pairs can be characterized distinctively based on their CRPs and CRQA metrics. This study also attempted to interpret the CRQA metrics in relation to how the pairs collaborated in order to provide a somewhat clear picture of their relevance and meaning. The analysis results could serve as a precursor in helping us understand what makes a programming pair more successful over other pairs and what behaviors exhibited by unsuccessful pairs that should be avoided.
Organization design as a competitive choice: an application to the study of innovation
Authors: Sengul Metin 
Published: December 2019

AbstractThis commentary reflects on how a perspective that concentrates on the role of competitive context and sees organization design as a competitive choice may inform the research stream on the link between organization design and innovation. Focusing on multiunit firms and their formal organization, I discuss the benefits of, and the need for, adopting such an approach for this research stream, in particular, and the study of organization design, in general. I conclude by outlining some implications and directions for future research.
Awareness of different forms of child abuse among Beni Suef University students: descriptive survey
Authors: Welson Nermeen N. , Mohamed Yasmen A. 
Published: December 2019

Abstract
Background
Child abuse is a worldwide phenomenon that can cause intense long-term aftereffects.

Aim
To evaluate the awareness of Beni Suef University students about different forms of child abuse as well as the size, causes, and complications of this problem in our society and determine the prevalence of physical child abuse.

Methods
The study included 1688 students from health science and non-health science colleges of Beni Suef University, Egypt. The study participants were asked to answer a questionnaire of two parts. The first part included questions about demographic data and personal experience of child abuse, and the second part included questions about opinions of participants on child abuse to assess their awareness and if there was any difference in the level of awareness between students of health science colleges and those of non-health science colleges.

Results
Health science college students were more life satisfied and felt more loved. Only 28.91% of the included students were not exposed to child abuse, while 12.59% of them suffered from wounds or fractures as a result of the abuse they were exposed to. About one third of the students thought that the commonest form of child abuse is verbal punishment such as threatening or humiliation and that the age at the greatest risk for abuse was the primary school age. About 68.36% of students thought that sexual abuse is a huge problem in our society. Only 21.56% of students disapproved child corporal punishment. More than half of the students stated that the most dangerous complication of child abuse is psychological problems such as depression. Most of the included students would talk to the child’s parents and advise them if they saw a case of abuse, while the least would call the police. Only half of the students disapproved female genital mutilation (FGM). The strongest predictive factors for FGM approval were rural residence and male sex. Students mainly thought that FGM is a social habit that is carried out for ethical causes. About half of the students approved legal punishment by the court for FGM performers.

Conclusion
A significant proportion of the students experienced physical child abuse which left no injuries in most cases; males and first academic year students show more exposure to abuse. Moreover, most of the students think that child corporal punishment can be allowed although about half of them think that the most dangerous aftereffect of child abuse is psychological problems. Lack of reporting the exposure to child abuse is explained by the largest percentage of students to be due to lack of awareness. Rural resident males show more approval of female genital mutilation. A significant lack of awareness about FGM complications is observed in both groups (the health science and non-health science college groups) and the opinions of both groups are very close.
Interaction between Fusarium head blight and crown rot disease incidence and cultural practices on wheat in the south of Iraq, Basra province
Authors: Minati Mohammed Hussein , Mohammed-Ameen Mohaned Khalaf 
Published: December 2019

Abstract
Background
This study was conducted to estimate Fusarium head blight (FHB) and crown rot (FCR) disease incidence on wheat and their interaction with cultural methods (cultivar types, planting time, seed rate, crop rotation, and fertilizer practices) that are used in wheat cropping system in the south of Iraq, Basra province.

Results
The results showed that the mean average of FHB and FCR was 27.2% and 31%, respectively. This displays that very nearly one-third of wheat crop planted in those 14 fields were infected by both diseases but not very severely, except in two fields (D and HM), which were devastating, 54% and 71% and 41% and 52% for FHB and FCR, respectively. The highest level of incidence for both diseases was associated with the earlier and latest planting dates 28 Oct. and 10 Dec., while the lowest was with 1, 10, and 23 Nov. A 200 and 120 kg/ha were the highest and lowest seed rates used in this study. The selected wheat fields differed in their pre-crop rotations (legume, corn, sorghum, okra, and continuous cropping system of wheat) in a previous year. The amount of added fertilizers (urea, DAP, and NPK) to the studied fields was in a high variation. The seven wheat cultivars examined in this study showed different levels of susceptibility to both diseases.

Conclusion
The results verified that most of the agricultural practices examined in this study were associated with positive correlation for FHB and FCR in the occurrence of disease incidence. Except the cultivar type and fertilizer application had unclear relationship with the incidence of both diseases.
Bt insecticidal efficacy variation and agronomic regulation in Bt cotton
Authors: LIU Zhenyu , ELTAYIB H M. A. Abidallha , WU Huimin , ZHOU Mingyuan , ZHANG Xiang , CHEN Yuan , CHEN Dehua 
Published: December 2019

AbstractThe bollworm can be controlled effectively with Bacillus thuringiensis transgenic cotton (Bt cotton) which is being applied worldwide. However, the insecticidal efficacy is not stable. Here we give a summary of research progress for the mechanism of the altered insecticidal efficacy, factors affecting the expression of insect resistance, agronomic practices on regulation of insecticidal efficacy in Bt cotton. To realize the transgenic potential of Bt cotton cultivars, future research may be conducted by increasing synthesis and reducing degradation of Bt protein to maintain high insecticidal ability in the transgenic cotton by agronomic management.
The Incretin Effect in Female Mice With Double Deletion of GLP-1 and GIP Receptors
Authors: Ahrén Bo , Yamada Yuichiro , Seino Yutaka 
Published: December 2019

AbstractTo establish the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) for the incretin effect after oral glucose, studies were undertaken in female mice with genetic deletion of receptors for GIP and GLP-1 (double incretin receptor knockout [DIRKO] mice) and their wild-type (WT) counterparts. Insulin secretion was explored after oral glucose (doses ranging from 0 to 100 mg), after intravenous glucose (doses ranging from 0 to 0.75 g/kg), and after oral and intravenous glucose at matching circulating glucose. DIRKO mice had glucose intolerance after oral glucose challenges in association with impaired beta-cell function. Suprabasal area under the curve for C-peptide (AUCC-peptide) correlated linearly with suprabasal AUCglucose both in WT (r = 0.942, P = .017) and DIRKO mice (r = 0.972, P = .006). The slope of this regression was lower in DIRKO than in WT mice (0.012 ± 0.006 vs 0.031 ± 0.006 nmol C-peptide/mmol glucose, P = .042). In contrast, there was no difference in the insulin response to intravenous glucose between WT and DIRKO mice. Furthermore, oral and intravenous glucose administration at matching glucose levels showed that the augmentation of insulin secretion after oral glucose (the incretin effect) in WT mice (11.8 ± 2.3 nmol/L min) was entirely absent in DIRKO mice (3.3 ± 1.2 nmol/L min). We conclude that GIP and GLP-1 are required for normal glucose tolerance and beta-cell function after oral glucose in mice, that they are the sole incretin hormones after oral glucose at higher dose levels, and that they contribute by 65% to insulin secretion after oral glucose.
Demonstration of a dual-channel two-dimensional reflection grating filter
Authors: Zhou Jianyu , Cheng Xinbin , Zhang Jinlong , Jiao Hongfei , Zhang Zhanyi , Li Haoran , Wang Zhanshan 
Published: December 2019

A dual-channel two-dimensional (2D) reflection grating filter operating around the 1.55 µm wavelength region is demonstrated, exhibiting dual-channel reflection peaks at 1.492 µm and 1.647 µm. The sidebands intrinsic to this kind of grating are suppressed by appropriately designed antireflective thin films, and this can be proved by equivalent medium theory. Using the modal analysis method, the excitation modes of the dual-channel reflection peaks are determined to be the TM0 (1.490 µm) and TE0 (1.638 µm) modes. The estimated relative errors in the wavelength determination of these modes are less than 1%. This is found to be in accord with analyses of the reflectivity spectra and electromagnetic fields. The dual-channel reflection peaks are sensitive to the background refractive index and may be useful in biosensing applications.
Los saberes de la historia política en la residencia docente: del discurso a la práctica
Authors: Campilia Mariano Luis , Druetta Matías Nicolás 
Published: December 2019

Compartimos avances de investigación donde nos preguntamos acerca de los saberes de la historia política que ponen en juego los practicantes durante la residencia docente. Es decir, cuáles son los posicionamientos teóricos que asumen al elaborar su propuesta de enseñanza y de qué manera se expresan en la práctica. Indagamos acerca de la enseñanza del pasado histórico desde la perspectiva de la Nueva Historia Política buscando reconocer y poner en tensión los alcances y limitaciones que presentan las propuestas respecto a esta dimensión particular del conocimiento histórico.
Al pensar qué, cómo y para qué enseñar, los residentes ponen en juego enfoques teórico-metodológicos. Pretendemos en ese sentido, visibilizar los acercamientos, tensiones y/o distanciamientos entre los supuestos teóricos y sus prácticas.
En este sentido, buscamos dar respuesta a los siguientes interrogantes: ¿qué vínculos se establecen con el pasado desde la dimensión política? ¿Cómo se trabaja la dominación, el poder, el conflicto, las resistencias, la intervención en el espacio público, la relación Estado-sociedad civil, los actores sociales, etc.?
Effectiveness of Mindfulness on Decreasing Stress in Health Professional Students: A Systematic Review
Authors: Fahmi Akhmad Yanuar , Dwidiyanti Meidiana , Wijayanti Diyan Yuli 
Published: December 2019

Background: Stress in health professional students is increasing every year. Therefore it is necessary to implement stress management for the students. Mindfulness is an alternative which can be used to deal with stress. Purpose: The purpose of this systematic review is to describe the effectiveness of mindfulness on decreasing stress in health professional students. Methods: This systematic review was conducted by searching relevant articles published in online databases EBSCO, Science Direct, PubMed, and Google. The search was restricted to the full-text articles published in 2010-2017 and employed the RCTs and non-RCTs research designs with a mindfulness intervention.Results: Of the ten articles reviewed, it was found that mindfulness could decrease stress in professional health students with a very significant p-value. The types of mindfulness administered to the health professional students included yoga therapy, MBSR therapy, and meditation therapy. In average, MBSR therapy is used for health professional students. This intervention is practiced through meditation which lasts for 5-35 minutes for 3-6 weeks. Conclusion: The study reported that, in average, the intervention to decrease stress in health professional students is performed by using MBSR with a meditation of 5-35 minutes. The intervention is done for 3-6 weeks. Results found that MBSR mindfulness could decrease stress. Further research is needed to explore the effectiveness of mindfulness on other subjects such as students who get scholarships.
The Influence of Mindfulness on the Decreasing Anxiety in Nursing Students to Support Academic Learning: A Literature Review
Authors: Wiguna Reza Indra , Dwidiyanti Meidiana , Sari Sri Padma 
Published: December 2019

Background: Anxiety and stress in nursing students has been shown to result in a lack of concentration, reduced learning productivity, and unfavorable physiological effects. This can cause a bad risk to the academic process of nursing students. A positive coping mechanism to reduce anxiety can be performed through various mindfulness training to support the academic success of nursing students.Purpose: This literature review study aimed to describe the influence of mindfulness on decreasing anxiety in nursing students to support academic learning, from various literature studies. Method: This study is a literature review. Data were collected through the online databases of EBSCO, PubMed, and ScienceDirect. The articles used in this study were determined published in 2010 to 2017. The key words used in searching for the articles were mindfulness, mindfulness in nursing students, nursing student anxiety, and nursing student achievement.Results: The results of this literature indicate that mindfulness is a holistic intervention that significantly improves mental health in nursing students. It can support students’ learning productivity to improve their academic achievement. The focus of mindfulness training program is to develop a better way to observe and concentrate, which in turn will facilitate a reduction in suffering and increased inner peace. Mindfulness will create relaxed attitudes and facilitates an open acceptance of experiences, thoughts, and learning.Conclusion: Mindfulness therapy with various types of exercises would be a good alternative for nursing students to reduce anxiety. Future studies should explore the long-term effects of mindfulness on the students’ learning productivity and academic achievement
Hubungan Antara Dukungan Sosial dengan Harga Diri pada Tunanetra Dewasa Mantan Awas di Kota Semarang
Authors: Savitri Vivi , Hartati Elis 
Published: December 2019

Background: Visually impaired people is one of the most common disabilities in Indonesia. The number of visually impaired people in Semarang City based on the data of Central Bureau of statisic 2015 was 806 people. Sudden blindness can lead to depression, improper self-perception, decreased levels of motivation, and low self-esteem. The existence of Sosial support is one of the ways to help blind people spared from those impacts. Sosial support helps to deal the blind people with problems that relate to physically, psychologically, and sosially.Purpose: The purpose of this study is to analyze the relationship between sosial support and self-esteem in the former blind adult in Semarang.Method: The research uses non experiment quantity method with correlation method. The sampling technique use 50 correspondent of total sample. Data collection using a sosial support questionnaire and Coopersmith Self Esteem Inventory (CSEI). Results: The results showed that there was a correlation between sosial support and self-esteem of blind adults in Semarang with positive direction. Sosial support has an important role to increase self-esteem, the higher sosial support given the higher self-esteem of the blinds people get. The community is expected to be a provider of sosial support for fellow community members to increase self-esteem of the former visually impaired.
Gambaran Risiko Gangguan Jiwa pada Korban Bencana Alam Gempa di Lombok Nusa Tenggara Barat
Authors: Dwidiyanti Meidiana , Hadi Irwan , Wiguna Reza Indra , Ningsih Hasanah Eka Wahyu 
Published: December 2019

Background: Earthquake is known as a disaster causing considerable health problems requiring immediate post trauma rehabilitation. Prominent health problem emerging after a disaster is psychiatric and mental health problem.Purpose: The study aimed to identify mental health risk and other significant problems growing among the victim’s post-earthquake in Lombok, West Nusa Tenggara, Indonesia.Method: Mix method approach, which was used throughout the study, is a strategy to obtain the data from the disaster victims of 88 people in Lombok. This study collected the data using Psychiatric and Mental Health Disorder Detection Questionnaire and symptom documentation form after practicing Mindfulness Spiritual. Results: The result showed that victims experienced neurosis symptom (85,2%), psychotic symptom (25,9%), PTSD symptom (64,7%) and 13 people did not experience mental health disorder risk. The qualitative study result showed that the earthquake victims grievance was afraid and feeling anxiety to enter the house due to earthquake incident, family relationship and economy problems, ghost issue and numerous diseases.Conclusion: Earthquake lead to psychiatric and mental health disorder and problems including mental health, economy, spiritual and physic aspects among people in Lombok, West Nusa Tenggara. It is essential for the future research to conduct a research about the description of mental health disorder after practicing mindfulness spiritual and planning the intervention that had been agreed by the respondent.