bluuebunny/crossref_metadata_2025_split huggingface dataset:
A theory‐driven psycho‐educational intervention programme for gynaecological cancer patients during treatment trajectory: A randomised controlled trial
Authors: Chow Ka Ming , Chan Carmen W.H. , Choi Kai Chow , Siu Ka Yi , Fung Hedy K.S. , Sum Wai Man 
Published: November 2019

AbstractObjectiveThis study aims to evaluate the effects of a theory‐driven psycho‐educational intervention programme on uncertainty in illness, anxiety, and sexual functioning in a cohort of Chinese patients with gynaecological cancer.MethodsWomen with newly diagnosed gynaecological cancer (n = 202) received either a four‐session, 12‐week‐long, culturally appropriate psycho‐educational intervention programme (n = 102) or attention from intervener (n = 100) in a two‐group randomised controlled trial. Patient‐reported measures included Chinese version of Mishel's Uncertainty in Illness Scale (C‐MUIS), Hospital Anxiety and Depression Scale (HADS)–Anxiety subscale, and Sexual Function‐Vaginal Changes Questionnaire (SVQ). Data regarding uncertainty in illness and anxiety were collected at baseline and postintervention, while data on sexual functioning were collected postintervention.ResultsPatients receiving psycho‐educational intervention reported significantly greater reductions in ambiguity, inconsistency, and overall uncertainty in illness, as measured by C‐MUIS (P < .01). They were also more likely to be sexually active (P = .037), report their partners having greater sexual interest (P = .008), and perceive a significantly greater level of intimacy (P = .001) in the SVQ.ConclusionsGiven the growing population of gynaecological cancer survivors and the universal side effects of the disease and its related treatments, the established design and content of the psycho‐educational intervention programme should be incorporated into routine clinical practice.
Identification of two novel trace impurities in mobile phases prepared with commercial formic acid
Authors: Bakota Erica L. , Levine Robert A. 
Published: November 2019

RationaleWhile liquid chromatography/high‐resolution mass spectrometry (LC/HRMS) is a versatile analytical technique, it is also sensitive to trace impurities. These impurities may come from a variety of sources, including reagents, solvents, and the sample matrix itself. Impurities in reagents may become concentrated and elute as peaks when a gradient method is used, and these peaks may cause suppression of peaks of interest both in the electrospray source, as well as in the C‐trap in systems that contain one.MethodsWe observed a notable increase in the size of several impurity peaks in a reversed‐phase gradient method upon switching suppliers of formic acid. We used LC/HRMS to separate and fragment these impurity compounds and assign probable formulae.ResultsThe mass spectra were compared with those of compounds found in the literature with the same formulae, and the observed peaks were matched to two amine compounds not previously reported as impurities in LC/MS systems: trihexylamine and N‐methyldihexylamine. The identities were confirmed by high‐resolution accurate mass and retention time matching against commercially available standards of these compounds.ConclusionsTo the best of our knowledge, this is the first time that trihexylamine and N‐methyldihexylamine have been reported in such systems. We hypothesize that these are derived from the formic acid manufacturing process and recommend that users monitor purchased formic acid for the presence of impurities.
Retention time shift analysis and correction in chemical isotope labeling liquid chromatography/mass spectrometry for metabolome analysis
Authors: Li Yunong , Li Liang 
Published: November 2019

RationaleIn chemical isotope labeling (CIL) liquid chromatography/mass spectrometry (LC/MS) metabolome analysis, the peak pairs of the same metabolite detected from different samples are aligned according to their mass and retention time (RT). Any RT shift of a peak pair in one of the sample files that falls outside the tolerance window will result in misalignment of the pair as a different metabolite. Thus, determination and correction of any significant RT shift are important to ensure the generation of high‐quality metabolome results.MethodsIn CIL LC/MS, the heavy‐isotope‐labeled pooled sample is spiked into all light‐isotope‐labeled individual samples. As a result, in the analysis of labeled samples of the same type, many common metabolites are detectable with high intensity in all LC/MS runs. We have developed a method to select a few of these metabolites as internal RT reference markers to check the occurrence of any RT shift in an LC/MS run. If a significant shift is found, an expanded list of these markers with their RT values covering the entire LC RT window is selected to serve as internal RT calibrants to recalibrate the chromatogram to correct any RT shift.ResultsWe developed a software program in R to perform RT check (RTC) and recalibration (RT‐calib). This program can quickly determine the occurrence of any RT shift falling outside a user‐defined threshold in an LC/MS run, thereby triggering a timely intervention to correct the problem (e.g., fixing a small leak or changing a column). In the analysis of 278 dansylation LC/MS runs of human urine samples, we show that the RT values can be corrected to be within a 30‐second window.ConclusionsAn RT‐check method and program tailored to CIL LC/MS metabolome analysis have been developed for quick detection and correction of RT shifts during the course of running many metabolome samples.
Biomechanical comparison of double versus triple button reconstruction techniques in patients with acromioclavicular joint dislocation
Authors: Civan Osman , Atmaca Halil , Uğur Levent 
Published: November 2019

AbstractBackgroundAlthough many techniques are used to treat the acromioclavicular (AC) joint dislocations, minimal invasive or arthroscopic coracoclavicular ligament reconstructions became popular recently. In this study, authors compared the biomechanical results of double versus triple button reconstruction techniques.MethodsThree‐dimensional solid modeling of the shoulder girdle was carried out using virtual finite element modeling. AC joint dislocation was applied to the reference model, and these models were repaired by double and triple button techniques, respectively. Maximum equivalent stresses on buttons and sutures as well as displacements and reaction forces on AC joint were evaluated.ResultsTriple button model was more stable during flexion and abduction when compared with double button technique.ConclusionMimicking conoid ligament has a crucial mission more particularly against resistance during frontal plane actions, but the absence of the trapezoid ligament causes increasing the posterior displacement of the distal clavicle during the flexion of GH joint.
Apoptosis induction and ERK/NF‐κB inactivation are associated with magnolol‐inhibited tumor progression in hepatocellular carcinoma in vivo
Authors: Tsai Jai‐Jen , Chen Jiann‐hwa , Chen Cheng Hsien , Chung Jing‐Gung , Hsu Fei‐Ting 
Published: November 2019

AbstractAlthough hepatitis B and/or hepatitis C virus were recognized as major risk factor for the development of hepatocellular carcinoma (HCC), certain occupational, environmental, and lifestyle factors also play key roles in HCC tumorigenesis. Moreover, in molecular signaling route, extracellular signal‐regulated kinase (ERK)/nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) signaling was found to be overexpressed and linked to poor prognosis in HCC. Thus, to identify possible nature compound that can suppress ERK/NF‐κB may be benefit to HCC patient. Magnolol, a natural compound derived from herbal plant Magnolia officinalis, has been recognized as a liver protection and antitumor reagent. However, whether magnolol‐inhibited HCC progression correlates with disruption of ERK/NF‐κB signaling is remained unclear. In this studies, we performed SK‐Hep1/luc2 HCC bearing animal model to investigate the anticancer efficacy and mechanism of magnolol on tumor progression. Tumor size and tumor growth rate were dramatically suppressed after treatment of magnolol. In addition, expression of phospho‐ERK (p‐ERK), NF‐κB p65 (Ser536), and tumor progression‐associated proteins, such as matrix metallopeptidase 9 (MMP‐9), vascular endothelial growth factor (VEGF), X‐linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. Most important, major extrinsic and intrinsic apoptosis signaling factors, including active caspase‐8 and caspase‐9 were both enhanced by magnolol. This study indicated that apoptosis induction through extrinsic/intrinsic pathways and blockage of ERK/NF‐κB activation were associated with magnolol‐inhibited tumor progression in HCC in vivo.
How Homework Shapes Family Literacy Practices
Authors: Clarke Carolyn , Comber Barbara 
Published: November 2019

AbstractThe authors explore the possibility that school literacy practices sent home as homework are changing family reading interactions by adding to the tasks that teachers expect parents to undertake. The authors consider how reading, formerly an elective leisure practice between parents and their children, has been reorganized and how this positions parents differently. The authors also examine teachers’ views on the importance of parents reading to their children and teachers’ expectations of parents to support school literacy practices in the form of homework. Evidence that teachers now depend on parents to support school‐based literacy practices and how this serves to change the nature of literacy practices in the home is discussed.
Supersymmetric Landau-Ginzburg tensor models
Authors: Chang Chi-Ming , Colin-Ellerin Sean , Rangamani Mukund 
Published: November 2019

Abstract
We study two dimensional $$ \mathcal{N} $$
N
= (2, 2) Landau-Ginzburg models with tensor valued superfields with the aim of constructing large central charge superconformal field theories which are solvable using large N techniques. We demonstrate the viability of such constructions and motivate the study of anisotropic tensor models. Such theories are a novel deformation of tensor models where we break the continuous symmetries while preserving the large N solvability. Specifically, we examine theories with superpotentials involving tensor contractions chosen to pick out melonic diagrams. The anisotropy is introduced by further biasing individual terms by different coefficients, all of the same order, to retain large N scaling. We carry out a detailed analysis of the resulting low energy fixed point and comment on potential applications to holography. Along the way we also examine gauged versions of the models (with partial anisotropy) and find generically that such theories have a non-compact Higgs branch of vacua.
Quantum correction to chaos in Schwarzian theory
Authors: Qi Yong-Hui , Sin Sang-Jin , Yoon Junggi 
Published: November 2019

Abstract
We discuss the quantum correction to chaos in the Schwarzian theory. We carry out the semi-classical analysis of the Schwarzian theory to study Feynman diagrams of the Schwarzian soft mode. We evaluate the contribution of the soft mode to the out-of- time-order correlator up to order 𝒪 (g4). We show that the quantum correction of order 𝒪 (g4) by the soft mode decreases the maximum Lyapunov exponent $$ \frac{2\pi }{\beta } $$

2
π

β

.
Holographic subregion complexity in general Vaidya geometry
Authors: Ling Yi , Liu Yuxuan , Niu Chao , Xiao Yikang , Zhang Cheng-Yong 
Published: November 2019

Abstract
We investigate general features of the evolution of holographic subregion complexity (HSC) on Vaidya-AdS metric with a general form. The spacetime is dual to a sudden quench process in quantum system and HSC is a measure of the “difference” between two mixed states. Based on the subregion CV (Complexity equals Volume) conjecture and in the large size limit, we extract out three distinct stages during the evolution of HSC: the stage of linear growth at the early time, the stage of linear growth with a slightly small rate during the intermediate time and the stage of linear decrease at the late time. The growth rates of the first two stages are compared with the Lloyd bound. We find that with some choices of certain parameter, the Lloyd bound is always saturated at the early time, while at the intermediate stage, the growth rate is always less than the Lloyd bound. Moreover, the fact that the behavior of CV conjecture and its version of the subregion in Vaidya spacetime implies that they are different even in the large size limit.
Testing Geochemical Predictions of Trace Element Toxicity and Bioavailability at a Rehabilitated Mine Site
Authors: Fairgray M. E. , Webster-Brown J. G. , Pope J. 
Published: November 2019

Abstract
The speciation, toxicity and bioavailability of trace elements in mine drainage environments can be readily predicted using geochemical modelling, and this is frequently the basis for assessing the likely impacts of mine effluents and efficacy of rehabilitation plans. However, such predictions are rarely validated against observed trace element characteristics after mine rehabilitation is complete. In this study of a former Pb–Zn mine in New Zealand, PHREEQC was used to predict dissolved trace element and sediment-bound speciation for the rehabilitated mine site, and the results were compared to the observed water and sediment quality. For Fe, Mn, Al, Cu, Pb, Zn, Cd, Ni, As, and Sb, it was predicted that only Zn2+ and Cd2+ concentrations would exceed recommended guideline values for ecosystem health. PHREEQC indicated that the pH would have to be raised to > 9.5 to reduce these toxicants to a level fit for ecosystem health. Modelling of potential mineral formation indicated that the waters were saturated with respect to a variety of Fe-, Mn- and Al (oxy)hydroxides at and immediately downstream of the mine site, but were not saturated with respect to any trace element-bearing minerals, or sulfide or carbonate phases. This was consistent with X-ray diffraction and scanning electron microscopy (SEM) observations of the sediment. Sequential extraction of the sediment showed strong associations of Zn, Cu, Pb, As and Sb with iron (oxy)hydroxides. Modelling trace element adsorption onto only hydrous ferric oxide surfaces accurately predicted the adsorption of Zn, Cd, Cu, and Ni, but predictions of Pb and As adsorption were less reliable. Additionally, a strong association between Zn and Mn oxyhydroxide was observed in SEM analysis.
Potential challenges and approaches to develop the large area efficient monolithic perovskite solar cells (mPSCs)
Authors: Mishra Arti , Ahmad Zubair 
Published: November 2019

Abstract
The next generation technologies based on perovskite solar cells (PSCs) are targeted to develop a true low cost, low tech, widely deployable, easily manufactured and reliable photovoltaics. After the extremely fast evolution in the last few years on the laboratory-scale, PSCs power conversion efficiency (PCE) reached over 24%. However, the widespread use of PSCs requires addressing the stability and industrial scale production issues. Carbon based monolithic perovskite solar cells (mPSCs) are one of the most promising candidates for the commercialization of the PSCs. mPSCs possess a unique architectural design and pave an easy way to produce large area and cost-effective fabrication of the PSCs. In this article, recent progress in the field of mPSCs, challenges and strategies for their improvement are briefly reviewed. Also, we focus on the predominant implementations of recent techniques in the fabrication of the mPSCs to improve their performance. This review is intended to serve as a future direction guide for the scientists who are looking forward to developing more reliable, cost-effective and large area PSCs.
A Framework for Automatic Morphological Feature Extraction and Analysis of Abdominal Organs in MRI Volumes
Authors: Asaturyan Hykoush , Thomas E. Louise , Bell Jimmy D. , Villarini Barbara 
Published: November 2019

Abstract
The accurate 3D reconstruction of organs from radiological scans is an essential tool in computer-aided diagnosis (CADx) and plays a critical role in clinical, biomedical and forensic science research. The structure and shape of the organ, combined with morphological measurements such as volume and curvature, can provide significant guidance towards establishing progression or severity of a condition, and thus support improved diagnosis and therapy planning. Furthermore, the classification and stratification of organ abnormalities aim to explore and investigate organ deformations following injury, trauma and illness. This paper presents a framework for automatic morphological feature extraction in computer-aided 3D organ reconstructions following organ segmentation in 3D radiological scans. Two different magnetic resonance imaging (MRI) datasets are evaluated. Using the MRI scans of 85 adult volunteers, the overall mean volume for the pancreas organ is 69.30 ± 32.50cm3, and the 3D global curvature is (35.23 ± 6.83) × 10−3. Another experiment evaluates the MRI scans of 30 volunteers, and achieves mean liver volume of 1547.48 ± 204.19cm3 and 3D global curvature (19.87 ± 3.62) × 10− 3. Both experiments highlight a negative correlation between 3D curvature and volume with a statistical difference (p < 0.0001). Such a tool can support the investigation into organ related conditions such as obesity, type 2 diabetes mellitus and liver disease.
Internal Dialogue as a Mediator of the Relationship Between Prayer and Well-Being
Authors: Puchalska-Wasyl Małgorzata M. , Zarzycka Beata 
Published: November 2019

Abstract
When people are praying, they are not only communicating with God (upward prayer), but also they are exploring their relationships with themselves (inward prayer) and with other people (outward prayer). Internal dialogical activity includes areas which correspond to upward, inward, and outward prayer. Therefore, the aim of this article is to examine whether and how internal dialogues can be mediators in the relationship between these three types of prayer and well-being. Data from 193 respondents (143 females) were analyzed in the study. We used: the Prayer Thoughts Scale, the Internal Dialogical Activity Scale, and the Psychological Well-Being Scale. The results showed that internal dialogue served as a mediator of the relationship between upward, inward, and outward prayer and well-being.
Evaluation of the relationship between the IL-17A gene expression level and regulatory miRNA-9 in relation to tumor progression in patients with non-small cell lung cancer: a pilot study
Authors: Migdalska-Sęk Monika , Góralska Katarzyna , Jabłoński Sławomir , Kordiak Jacek , Nawrot Ewa , Kiszałkiewicz Justyna M. , Pastuszak-Lewandoska Dorota , Baran Kamila , Stuss Michał , Brzeziańska-Lasota Ewa 
Published: November 2019

Abstract
A pro-inflammatory cytokine, IL-17A, is associated with increased risk of developing numerous cancers, including non-small cell lung cancer (NSCLC). IL-17A is a target gene for miR-9. This encouraged us to analyze these two genes in terms of their usefulness as prognostic markers in NSCLC. The expression levels of IL-17A gene and miR-9 was assessed in 26 NSCLC tissue samples and 26 unchanged lung tissue adjacent to lung tumors (control tissue), using qPCR. In both tissue groups, a decreased expression of IL-17A was observed in 100% of samples. Increased expression of miRNA-9 was observed in 92% of tumor samples, and in 100% of control samples. Neither statistical differences in the level of expression IL-17A depending on the patient’s age, gender, smoking status, nor histopathology of the cancer was found. Regarding the presence of nodule metastasis (‘N’ value in TNM classification), significantly lower expression level of IL-17A was observed in cN2 as compared with cN1 group. Additionally, statistically lower IL-17A expression was found in III versus II tumor stage (cAJCC classification). Significant negative correlation between both studied genes was revealed in SCC subgroup. This leads to the conclusion that miRNA-9 can regulate the expression of IL-17A as an IL-17A mRNA antagonistic mediator. Inhibition of proinflammatory action of IL-17A in correlation with tumor progression can be related to various activity of Th17 cells on cancer development according to its immunogenicity, and also may suggest suppressive role of IL-17A in tumor progression. However, because of low number of analyzed samples, further studies on the functional role of IL-17A in development and/or progression NSCLC seem warranted.
A bibliometric approach to finding fields that co-evolved with information technology
Authors: Iwami Shino , Ojala Arto , Watanabe Chihiro , Neittaanmäki Pekka 
Published: November 2019

Abstract
Among the declining industries, for example music industry, some have been revived by information technology (IT). At the same time, in academic fields, some have expected co-evolutions between IT and other fields to cause the resurgence of either field. In this research, the clustering of citation networks with 14,438 academic papers resulted in the identification of 28 academic fields in the areas “Computer Science” or “Information Science and Library Science.” Co-evolutions between these 28 fields and citing fields to the 28 fields were evaluated by an investigation of contents; a methodology to search co-evolutions was also proposed. This paper proposes that pairs of academic fields (with both high correlation and high dissimilarity) co-evolve, and some co-evolving pairs of academic fields were found. This research contributes to the discovery of the co-evolution between academic fields.
Statistical Modeling of Craniofacial Shape and Texture
Authors: Dai Hang , Pears Nick , Smith William , Duncan Christian 
Published: November 2019

Abstract
We present a fully-automatic statistical 3D shape modeling approach and apply it to a large dataset of 3D images, the Headspace dataset, thus generating the first public shape-and-texture 3D morphable model (3DMM) of the full human head. Our approach is the first to employ a template that adapts to the dataset subject before dense morphing. This is fully automatic and achieved using 2D facial landmarking, projection to 3D shape, and mesh editing. In dense template morphing, we improve on the well-known Coherent Point Drift algorithm, by incorporating iterative data-sampling and alignment. Our evaluations demonstrate that our method has better performance in correspondence accuracy and modeling ability when compared with other competing algorithms. We propose a texture map refinement scheme to build high quality texture maps and texture model. We present several applications that include the first clinical use of craniofacial 3DMMs in the assessment of different types of surgical intervention applied to a craniosynostosis patient group.