bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health care providers’ weight management practices for adolescent obesity and alignment with clinical practice guidelines: a multi-centre, qualitative study
Authors: Kebbe M. , Perez A. , Buchholz A. , Scott S. D. , McHugh T.-L. F. , Dyson M. P. , Ball G.D.C. 
Published: September 2020

Abstract
Background
Clinical practice guidelines (CPGs) include evidence-based recommendations for managing obesity in adolescents. However, information on how health care providers (HCPs) implement these recommendations in day-to-day practice is limited. Our objectives were to explore how HCPs deliver weight management health services to adolescents with obesity and describe the extent to which their reported practices align with recent CPGs for managing pediatric obesity.

Methods
From July 2017 to January 2018, we conducted a qualitative study that used purposeful sampling to recruit HCPs with experience in adolescent weight management from multidisciplinary, pediatric weight management clinics in Edmonton and Ottawa, Canada. Data were collected using audio-recorded focus groups (4–6 participants/group; 60–90 min in length). We applied inductive, semantic thematic analysis and the congruent methodological approach to analyze our data, which included transcripts, field notes, and memos. Qualitative data were compared to recent CPGs for pediatric obesity that were published by the Endocrine Society in 2017. Of the 12 obesity ‘treatment-related’ recommendations, four were directly relevant to the current study.

Results
Data were collected through three focus groups with 16 HCPs (n = 10 Edmonton; n = 6 Ottawa; 94% female; 100% Caucasian), including dietitians, exercise specialists, nurses, pediatricians, psychologists, and social workers. We identified three main themes that we later compared with CPG recommendations, including: (i) discuss realistic expectations regarding weight management (e.g., shift focus from weight to health; explore family cohesiveness; foster delayed vs instant gratification), (ii) personalize weight management (e.g., address personal barriers to change; consider developmental readiness), and (iii) exhibit non-biased attitudes and practices (e.g., de-emphasize individual causes of obesity; avoid making assumptions about lifestyle behaviors based on weight). Based on these qualitative findings, HCPs applied all four CPG recommendations in their practices.

Conclusions
HCPs provided practical insights into what and how they delivered weight management for adolescents, which included operationalizing relevant CPG recommendations in their practices.
The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
Authors: MacLean M. A. , Kamintsky L. , Leck E. D. , Friedman A. 
Published: September 2020

AbstractHuman coronaviruses are highly pathogenic viruses that pose a serious threat to human health. Examples include the severe acute respiratory syndrome outbreak of 2003 (SARS-CoV-1), the Middle East Respiratory Syndrome (MERS-CoV) outbreak of 2012, and the current SARS-CoV-2 (COVID-19) pandemic. Herein, we review the neurological manifestations of coronaviruses and discuss the potential pathogenic role of blood–brain barrier dysfunction. We present the hypothesis that pre-existing vascular damage (due to aging, cardiovascular disease, diabetes, hypertension or other conditions) facilitates infiltration of the virus into the central nervous system (CNS), increasing neuro-inflammation and the likelihood of neurological symptoms. We also discuss the role of a neuroinflammatory cytokine profile in both blood–brain barrier dysfunction and macrovascular disease (e.g. ischemic stroke and thromboembolism). Future studies are needed to better understand the involvement of the microvasculature in coronavirus neuropathology, and to test the diagnostic potential of minimally-invasive screening tools (e.g. serum biomarkers, fluorescein retinal angiography and dynamic-contrast MRI).
The therapeutic effect to eldecalcitol + bisphosphonate is superior to bisphosphonate alone in the treatment of osteoporosis: a meta-analysis
Authors: Zheng Zaoqian , Luo Jinyu 
Published: September 2020

Abstract
Background
Osteoporosis is a metabolic bone disease. Bisphosphonate (BP) and eldecalcitol (ELD) are two clinical first-line drugs for osteoporosis patients. However, the effect of ELD + BP vs. BP alone on osteoporosis treatment is still unclear. The present meta-analysis was conducted to evaluate the different therapeutic effect of BP + ELD vs. BP alone in osteoporosis treatment.

Methods
Eligible documents that selected from online databases including PubMed, Embase, and Cochrane Library were included in this study (updated to March 3, 2020). The quality assessment of the included studies was based on the guidelines of Cochrane. Meta-analysis was performed according to criteria such as intervention plan and outcome. The indicators including bone mineral density (BMD) in all enrolled studies were included in the current analysis. Pooled odds ratios (ORs) and weighted mean differences (WMDs) with 95% confidence intervals (CI) were calculated using fixed- or random-effects models. Then, heterogeneity analysis was performed based on Cochran’s Q test and I2 statistics.

Results
A total of 4 studies (456 cases) with high quality were enrolled in this study. The effect of ELD + BP was superior to BP alone based on indicators including femoral neck BMD (FN-BMD) and total hip BMD (TH-BMD) in patients with followed up ≤ 6 months. Moreover, the effect of ELD + BP was superior to BP alone based on lumbar spine BMD (LS-BMD) in patients with 12 months followed up.

Conclusion
Therapeutic effect of ELD + BP was superior to BP alone in osteoporotic patients based on the influence of BMD.
Optimal surgical methods to treat intertrochanteric fracture: a Bayesian network meta-analysis based on 36 randomized controlled trials
Authors: Cheng Yan-xiao , Sheng Xia 
Published: September 2020

AbstractBackgroundThere are several surgical methods to treat intertrochanteric fracture: dynamic hip screw (DHS), compression hip screw (CHS), percutaneous compression plate (PCCP), Medoff sliding plate, less invasive stabilization system (LISS), Gamma nail, proximal femoral nail (PFN), and proximal femoral nail anti-rotating (PFNA). We therefore conducted a network meta-analysis to compare eight surgical interventions, including DHS, CHS, PCCP, Medoff sliding plate, LISS, Gamma nail, PFN, and PFNA, to provide the optimal surgical intervention for intertrochanteric fracture.MethodsAn electronic search of 4 databases (PubMed, Embase, Cochrane library, and Web of Science) from inception to July 2020. Two or more of the eight surgical interventions, including the DHS, CHS, PCCP, Medoff sliding plate, LISS, Gamma nail, PFN, and PFNA, for intertrochanteric fracture were included. The methodological quality of the included studies was assessed using the Cochrane Collaboration risk of bias (ROB) tool. Network meta-analysis was conducted by using R-3.5.1 software with the help of package “gemtc”. The odd ratios (ORs) with 95% credibility interval (CrI) were used to assess complications and standard mean difference (SMD) with 95% CrI to calculate the continuous outcomes (operative time, intraoperative blood loss, and Harris hip score). Surfaces under the cumulative ranking curves (SUCRA) were used to rank the intervention.ResultsA total of 36 RCTs were included in this study. The results of this network meta-analysis showed that, compared with the CHS and DHS group, PFNA exhibited a beneficial role in reducing the blood loss (SMD, 152.50; 95% CrI, 72.93 to 232.45; and SMD, 184.40; 95% CrI, 132.99 to 235.90, respectively). PFNA achieved the lowest value for the surface under the cumulative ranking curve (SUCRA) for the blood loss (SURCA = 0.072) and highest of Harris hip score (SURCA = 0.912). PCCP may have the lowest probability of the operative time (SURCA = 0.095). There were no significant differences among the eight surgical procedures in complications.ConclusionPFNA technique is the optimal treatment method for intertrochanteric fracture. Larger, longitudinal RCTs addressing current limitations, including sources of bias, inconsistency, and imprecision, are needed to provide more robust and consistent evidence.
A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial
Authors: Yang Shaoying , Ni Ruoning , Lu Yikang , Wang Suli , Xie Feng , Zhang Chunyan , Lu Liangjing 
Published: September 2020

AbstractBackgroundUndifferentiated connective tissue disease (UCTD) is known to induce adverse pregnancy outcomes and even recurrent spontaneous abortion (RSA) by placental vascular damage and inflammation activation. Anticoagulation can prevent pregnancy morbidities. However, it is unknown whether the addition of immune suppressants to anticoagulation can prevent spontaneous pregnancy loss in UCTD patients. The purpose of this study is to evaluate the efficacy of hydroxychloroquine (HCQ) and low-dose prednisone on recurrent pregnancy loss for women with UCTD.MethodsThe Immunosuppressant for Living Fetuses (ILIFE) Trial is a three-arm, multicenter, open-label randomized controlled trial with the primary objective of comparing hydroxychloroquine combined with low-dose prednisone and anticoagulation with anticoagulation alone in treating UCTD women with recurrent spontaneous abortion. The third arm of using hydroxychloroquine combined with anticoagulant for secondary comparison. A total of 426 eligible patients will be randomly assigned to each of the three arms with a 1:1:1 allocation ratio. The primary outcome is the rate of live births. Secondary outcomes include adverse pregnancy outcomes and progression of UCTD.DiscussionThis is the first multi-center, open-label, randomized controlled trial which evaluates the efficacy of immunosuppressant regimens on pregnancy outcomes and UCTD progression. It will provide evidence on whether the immunosuppressant ameliorates the pregnancy prognosis in UCTD patients with RSA and the progression into defined connective tissue disease.Trial registrationClinicalTrials.govNCT03671174. Registered on 14 September 2018.
A mathematical analysis of a system of Caputo–Fabrizio fractional differential equations for the anthrax disease model in animals
Authors: Rezapour Shahram , Etemad Sina , Mohammadi Hakimeh 
Published: September 2020

AbstractWe study a fractional-order model for the anthrax disease between animals based on the Caputo–Fabrizio derivative. First, we derive an existence criterion of solutions for the proposed fractional$\mathcal {CF}$CF-system of the anthrax disease model by utilizing the Picard–Lindelof technique. By obtaining the basic reproduction number$\mathcal{R}_{0}$R0of the fractional$\mathcal{CF}$CF-system we compute two disease-free and endemic equilibrium points and check the asymptotic stability property. Moreover, by applying an iterative approach based on the Sumudu transform we investigate the stability of the fractional$\mathcal{CF}$CF-system. We obtain approximate series solutions of this system by means of the homotopy analysis transform method, in which we invoke the linear Laplace transform. Finally, after the convergence analysis of the numerical method HATM, we present a numerical simulation of the$\mathcal{CF}$CF-fractional anthrax disease model and review the dynamical behavior of the solutions of this$\mathcal {CF}$CF-system during a time interval.
Sorption of urea hydrogen peroxide by co-pyrolysed bone meal and cow dung slowed-down phosphorus and nitrogen releases but boosted agronomic efficiency
Authors: Luyima Deogratius , Sung Jwakyung , Lee Jae-Han , Woo Seong-Ah , Park Seong-Jin , Oh Taek-Keun 
Published: September 2020

AbstractCo-pyrolysis of animal manure biomass with bone meal (BM) and soaking of the resultant biochar in urea containing solutions may offer a sustainable and cheap way of formulating slow-release nitrogen (N) and phosphorus (P) fertilisers. This method can lead to optimisation of the carbon sequestration capacity of the biochar, abatement of environmental pollution by P and N and alleviation of the severity of the projected future scarcity of P. A few studies have indicated that sorption can create efficient slow-release fertilisers although all of them utilised charged moieties such as ammonium ions to formulate them and as a result, there is a paucity of data concerning the efficiency of fertilisers formulated using uncharged compounds like urea. It’s against that background that we examined the possibility of leveraging co-pyrolysis and sorption with urea containing solutions to formulate slow-release N and P fertilisers along with assessing the agronomic efficiency of the formulated fertilisers through cultivating lettuce in pots for two seasons. Both urea-hydrogen peroxide (UHP) and urea were utilised as N sources. UHP (CDBM-UHP) and urea (CDBM-Urea) containing biochars averagely released 64.40% and 87.00% of the added N, respectively over the 28-day incubation period with the amount of N released decreasing with increasing concentrations of BM in the biochar. Lettuce yields and nutrient use efficiencies of N and P were higher in the CDBM-UHP than in the CDBM-Urea treatments. It’s therefore clear that sorption of UHP by BM containing biochar concomitantly slows-down releases of N and P and boosts the agronomic efficiency of the fertilisers.
Assessment of genetic risk for improved clinical-neuropathological correlations
Authors: Spencer Barbara E. , Jennings Robin G. , Fan Chun C. , Brewer James B. 
Published: September 2020

AbstractIn the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology. In the present study we tested the ability of polygenic scores for Alzheimer’s disease, dementia with Lewy bodies, and Parkinson’s disease to differentiate individuals in a 2713-participant, pathologically defined sample. A dementia with Lewy bodies polygenic score that excluded apolipoprotein E due to its overlap with Alzheimer’s disease risk was specifically associated with at least limbic (transitional) Lewy-related pathology and a pathological diagnosis of dementia with Lewy bodies. An Alzheimer’s disease polygenic score was associated with neuritic plaques and neurofibrillary tangles but not Lewy-related pathology, and was most strongly associated with an Alzheimer’s pathological diagnosis. Our results indicate that an assessment of genetic risk may be useful to clinically distinguish between Alzheimer’s disease and dementia with Lewy bodies. Notably, we found no association with a Parkinson’s disease polygenic score, which aligns with evidence that dementia with Lewy bodies has a distinct genetic signature that can be exploited to improve clinical diagnoses.
Managing intra-articular deformity in high Tibial osteotomy: a narrative review
Authors: Micicoi Grégoire , Khakha Raghbir , Kley Kristian , Wilson Adrian , Cerciello Simone , Ollivier Matthieu 
Published: September 2020

AbstractThe joint line convergence angle (JLCA) has a normal range between 0° to 2°, which increases in magnitude depending on the severity and stage of osteoarthritis in the knee.The JLCA represents the interaction of the intra-articular deformity arising from the osteoarthritis and the surrounding soft tissue laxity. Therefore, the JLCA has become a vital parameter in analysing the long leg alignment views for corrective planning before osteotomy surgery. Recent studies have considered the influence on how the preoperative JLCA is measured and its influence on achieving accurate postoperative desired correction in high tibial osteotomy surgery.The JLCA also reflects the influence of soft tissue laxity in a lower limb malalignment and many surgeons encourage it to be taken into account to avoid non physiological correction and/or overcorrection with negatively impacted postoperative patient outcome.This present review addressed how to obtain an accurate preoperative measurement of the JLCA, its influence on postoperative deformity analysis and how to reduce errors arising from an elevated preoperative JLCA.We have proposed a formula to help determine the value to subtract from the planned correction in order to avoid an overcorrection when performing a corrective osteotomy.Level of clinical evidence IV, narrative review.
LncRNA SNHG14 promotes OGD/R-induced neuron injury by inducing excessive mitophagy via miR-182-5p/BINP3 axis in HT22 mouse hippocampal neuronal cells
Authors: Deng Zexiang , Ou Hao , Ren Fei , Guan Yujiao , Huan Ye , Cai Hongwei , Sun Bei 
Published: September 2020

Abstract
Background
Long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) is associated with cerebral ischemia–reperfusion (CI/R) injury. This work aims to explore the role of SNHG14 in CI/R injury.

Methods
HT22 (mouse hippocampal neuronal cells) cell model was established by oxygen–glucose deprivation/reoxygenation (OGD/R) treatment. The interaction among SNHG14, miR-182-5p and BNIP3 was verified by luciferase reporter assay. Flow cytometry, western blot and quantitative real-time PCR were performed to examine apoptosis, the expression of genes and proteins.

Results
SNHG14 and BNIP3 were highly expressed, and miR-182-5p was down-regulated in the OGD/R-induced HT22 cells. OGD/R-induced HT22 cells exhibited an increase in apoptosis. SNHG14 overexpression promoted apoptosis and the expression of cleaved-caspase-3 and cleaved-caspase-9 in the OGD/R-induced HT22 cells. Moreover, SNHG14 up-regulation enhanced the expression of BNIP3, Beclin-1, and LC3II/LC3I in the OGD/R-induced HT22 cells. Furthermore, SNHG14 regulated BNIP3 expression by sponging miR-182-5p. MiR-182-5p overexpression or BNIP3 knockdown repressed apoptosis in OGD/R-induced HT22 cells, which was abolished by SNHG14 up-regulation.

Conclusion
Our study demonstrates that lncRNA SNHG14 promotes OGD/R-induced neuron injury by inducing excessive mitophagy via miR-182-5p/BINP3 axis in HT22 mouse hippocampal neuronal cells. Thus, SNHG14/miR-182-5p/BINP3 axis may be a valuable target for CI/R injury therapies.
Impact of sample size on the stability of risk scores from clinical prediction models: a case study in cardiovascular disease
Authors: Pate Alexander , Emsley Richard , Sperrin Matthew , Martin Glen P. , van Staa Tjeerd 
Published: September 2020

AbstractBackgroundStability of risk estimates from prediction models may be highly dependent on the sample size of the dataset available for model derivation. In this paper, we evaluate the stability of cardiovascular disease risk scores for individual patients when using different sample sizes for model derivation; such sample sizes include those similar to models recommended in the national guidelines, and those based on recently published sample size formula for prediction models.MethodsWe mimicked the process of samplingNpatients from a population to develop a risk prediction model by sampling patients from the Clinical Practice Research Datalink. A cardiovascular disease risk prediction model was developed on this sample and used to generate risk scores for an independent cohort of patients. This process was repeated 1000 times, giving a distribution of risks for each patient.N= 100,000, 50,000, 10,000,Nmin(derived from sample size formula) andNepv10(meets 10 events per predictor rule) were considered. The 5–95th percentile range of risks across these models was used to evaluate instability. Patients were grouped by a risk derived from a model developed on the entire population (population-derived risk) to summarise results.ResultsFor a sample size of 100,000, the median 5–95th percentile range of risks for patients across the 1000 models was 0.77%, 1.60%, 2.42% and 3.22% for patients with population-derived risks of 4–5%, 9–10%, 14–15% and 19–20% respectively; forN= 10,000, it was 2.49%, 5.23%, 7.92% and 10.59%, and forNusing the formula-derived sample size, it was 6.79%, 14.41%, 21.89% and 29.21%. Restricting this analysis to models with high discrimination, good calibration or small mean absolute prediction error reduced the percentile range, but high levels of instability remained.ConclusionsWidely used cardiovascular disease risk prediction models suffer from high levels of instability induced by sampling variation. Many models will also suffer from overfitting (a closely linked concept), but at acceptable levels of overfitting, there may still be high levels of instability in individual risk. Stability of risk estimates should be a criterion when determining the minimum sample size to develop models.
Performance of the parasitoid species Aphelinus asychis Walker (Hymenoptera: Aphelinidae), Aphidius ervi (Haliday) (Hymenoptera: Braconidae) and Diaeretiella rapae (McIntosh) (Hymenoptera: Braconidae), using Myzus persicae (Sulzer) (Hemiptera: Aphididae) as host
Authors: Kumar Surjeet , Kashyap Shruti , Soni Saurbh 
Published: September 2020

AbstractThree parasitoid species viz. Aphelinus asychis Walker (Hymenoptera: Aphelinidae), Aphidius ervi (Haliday) (Hymenoptera: Braconidae) and Diaeretiella rapae (McIntosh) (Hymenoptera: Braconidae) parasitizing the aphid species Myzus persicae (Sulzer) (Hemiptera: Aphididae) in mid-hills of north India were studied. At different locations and times of the year, the parasitization by A. asychis, A. ervi, and D. rapae ranged from 7.53 to 37.58, 4.26 to 80.45, and 74.25 to 80.48%, respectively. All the 3 parasitoids successfully completed their development on different nymphal instars of the aphid host and the total developmental duration of A. asychis, A. ervi, and D. rapae ranged 10.4–14.6, 24.2–29.6, and 10.2–15.2 days, respectively. It was significantly longer on the 1st nymphal instar of the host. The longevity of the female parasitoids was significantly longer than their counterparts. Differences in host age significantly influenced the longevity of female parasitoids and it was more on 1 to 2-day-old nymphs than that on 4 to 5-day-old nymphs. Fecundity and ovipositional periods of the parasitoids on younger (1–2 days old) host age group were considerably prolonged than on the older ages of the aphid. Average total fecundity of A. asychis and D. rapae was significantly higher when parasitizing 1–2-day-old nymphs. In A. asychis, host feeding behavior was also observed by a total host feeding of 89.2 aphids (1–2 days old) and 43.4 aphids (4–5 days old) during its life span. It is concluded that A. asychis, A. ervi, and D. rapae can be mass reared using M. persicae as host and can be utilized successfully in augmentative biological control program.