bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption
Authors: Rashwan Ayat S. , El-Beltagy Marwa A. , Saleh Sherif Y. , Ibrahim Ibrahim A. 
Published: December 2019

Abstract
Background
One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source of most available medicines. Cinnamaldehyde (CNA) is an active principle of Cinnamomum zeylanicum. Costunolide (CE) is natural sesquiterpene lactones, which is the main bioactive constituent of Saussurea lappa. The main aim of the present study is to investigate the effect of the synthetic antidiabetic agent (metformin) in comparison with natural constituents (cinnamaldehyde, costunolide) after developing a reliable model for insulin resistance by using high fructose diet (HFD).

Results
It was found that HFD increased plasma glucose, insulin, glycosylated hemoglobin, HbA1c, serum total cholesterol, LDL-cholesterol, triglyceride, ALT, AST, creatinine, and uric acid. Moreover, HFD decreased hepatic reduced glutathione and superoxide dismutase levels. While oral administration of cinnamaldehyde and costunolide significantly decreased plasma glucose, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, and increased level of hepatic reduced glutathione and superoxide dismutase activity. Also, cinnamaldehyde and costunolide restored the altered plasma levels of ALT, AST, creatinine, and uric acid to normal.

Conclusions
The results of this experimental study showed that cinnamaldehyde and costunolide could be used as safe drugs for treating different abnormalities of metabolic syndrome.
Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma
Authors: Kann Benjamin H. , Hicks Daniel F. , Payabvash Sam , Mahajan Amit , Du Justin , Gupta Vishal , Park Henry S. , Yu James B. , Yarbrough Wendell G. , Burtness Barbara A. , Husain Zain A. , Aneja Sanjay 
Published: December 2019

PURPOSE Extranodal extension (ENE) is a well-established poor prognosticator and an indication for adjuvant treatment escalation in patients with head and neck squamous cell carcinoma (HNSCC). Identification of ENE on pretreatment imaging represents a diagnostic challenge that limits its clinical utility. We previously developed a deep learning algorithm that identifies ENE on pretreatment computed tomography (CT) imaging in patients with HNSCC. We sought to validate our algorithm performance for patients from a diverse set of institutions and compare its diagnostic ability to that of expert diagnosticians. METHODS We obtained preoperative, contrast-enhanced CT scans and corresponding pathology results from two external data sets of patients with HNSCC: an external institution and The Cancer Genome Atlas (TCGA) HNSCC imaging data. Lymph nodes were segmented and annotated as ENE-positive or ENE-negative on the basis of pathologic confirmation. Deep learning algorithm performance was evaluated and compared directly to two board-certified neuroradiologists. RESULTS A total of 200 lymph nodes were examined in the external validation data sets. For lymph nodes from the external institution, the algorithm achieved an area under the receiver operating characteristic curve (AUC) of 0.84 (83.1% accuracy), outperforming radiologists’ AUCs of 0.70 and 0.71 ( P = .02 and P = .01). Similarly, for lymph nodes from the TCGA, the algorithm achieved an AUC of 0.90 (88.6% accuracy), outperforming radiologist AUCs of 0.60 and 0.82 ( P < .0001 and P = .16). Radiologist diagnostic accuracy improved when receiving deep learning assistance. CONCLUSION Deep learning successfully identified ENE on pretreatment imaging across multiple institutions, exceeding the diagnostic ability of radiologists with specialized head and neck experience. Our findings suggest that deep learning has utility in the identification of ENE in patients with HNSCC and has the potential to be integrated into clinical decision making.
Narrativas de mujeres activistas: participación y transformación entre lo personal y lo político
Authors: Gonzalez Maria Fernanda 
Published: December 2019

Este trabajo presenta un aporte a la comprensión de la actuación activista desde la psicología cultural. Se elabora una aproximación teórica y empírica basada en los conceptos de actuación humana transformadora, compromiso moral y producción de narrativas biográficas en su dimensión política. Se presenta una investigación cualitativa en la que se estudian las narrativas de doce mujeres activistas por los derechos sexuales y reproductivos, en Entre Ríos, Argentina. Se realizó un análisis temático y dialógico de los temas, posicionamientos y emociones. Los resultados indican que en las narrativas se traman elementos personales-biográficos con otros de índole social o política. Los posicionamientos son fluidos entre el yo y el nosotras, mientras que las emociones y las valoraciones aparecen en relación con la propia participación activista y los procesos de transformación social. La interrelación entre los elementos teóricos y los resultados empíricos permite avanzar en una conceptualización de los activismos feministas desde la psicología cultural, con énfasis en los procesos de participación y de transformación en las dimensiones personales y sociopolíticas.
Desarrollo del Self Dialógico en mujeres obesas: un estudio longitudinal desde la psicología cultural
Authors: Uchoa Branco Angela , Oliveira Silva Milena 
Published: December 2019

El presente estudio investiga cómo los prejuicios culturales y el rechazo social pueden tener un efecto significativo en el desarrollo del Self dialógico de mujeres obesas. El estudio adopta un enfoque metodológico longitudinal en el que se analizaron las trayectorias de desarrollo de tres mujeres obesas durante un período de dos años durante el cual se sometieron a cirugía bariátrica para perder peso. El objetivo fue identificar y analizar las configuraciones dialógicas de estas mujeres, antes, inmediatamente después y meses después de la cirugía. Algunas de las preguntas de investigación fueron: ¿cómo se posicionaron las mujeres en los tres momentos de la investigación? ¿Qué otros grupos sociales contribuyeron a los cambios en su Self dialógico? ¿Cuál es el impacto del Self imaginado en el futuro en las posiciones presentadas? Los resultados revelan aspectos importantes de la dinámica del desarrollo del Self, impulsados por el poder de canalización cultural del prejuicio. Sin embargo, cada mujer usó idiosincráticamente diferentes estrategias y reaccionó de manera diferente a los prejuicios y a la experiencia de la pérdida de peso, lo que revela las complejidades de su Self dialógico en procesos constantes de desarrollo.
PROMOÇÃO DO ALEITAMENTO MATERNO COM IDOSOS: EXPERIÊNCIA EM PROJETO DE EXTENSÃO UNIVERSITÁRIA - UERJ
Authors: Tavares Elda Lima , Menezes Maria Fátima Garcia de , Bahia Eriane Da Silva , Martins Tatiane Cristina Ferreira , Basílio Erika De Melo , Freire Julliana Ayres Lima , Santos Debora Martins 
Published: December 2019

O curso Alimentação, Nutrição e Terceira Idade é a principal atividade do projeto de extensão Alimentação, Nutrição e Envelhecimento, do Instituto de Nutrição em parceria com a Universidade Aberta da Terceira Idade/UERJ. Tem como referencial teórico a Promoção da Saúde e a Educação Popular em Saúde. É desenvolvido em aulas semanais, valorizando o alimento. Inclui, desde 2008, aula sobre aleitamento materno. O presente estudo objetiva relatar a experiência da abordagem do tema nos últimos dez anos. Metodologias lúdicas e interativas, valorizando o diálogo, o respeito aos diferentes saberes e a problematização do tema oportunizaram o debate das vivências pessoais no papel de mãe e avó; crenças e tabus que envolvem a prática do aleitamento; manejo adequado da amamentação e importância do apoio ao aleitamento materno exclusivo. As técnicas pedagógicas utilizadas foram: dramatização, produção de frases, demonstração e discussão em grupos. Estas permitiram o espaço para a reflexão e troca de experiências entre as idosas, como mães e em seu novo papel de avós. As falas das idosas evidenciaram mudanças nas orientações e técnicas para o aleitamento, de sua época para a atualidade e diferenças culturais na experiência (“antigamente” como algo privado, em que a mulher deveria estar recolhida). Por fim, tem papel de destaque o debate sobre a importância das relações intergeracionais e o papel da “avó” no apoio ao aleitamento, reconhecido como sinônimo de amor. A experiência possibilitou um debate instigante sobre a complexidade das questões que envolvem o aleitamento materno e sua evolução ao longo do tempo. DOI: 10.12957/demetra.2019.43804
Sexting: percepções de adolescentes sobre o fenômeno e acerca do papel das relações familiares
Authors: Cardoso André Tavares , Falcke Denise , Mosmann Clarisse Pereira 
Published: December 2019

Pesquisas sobre sexting vêm abordando quantitativamente aspectos da individualidade dos adolescentes, desconsiderando suas percepções. Portanto, o objetivo dessa pesquisa qualitativa e descritiva foi conhecer a percepção de adolescentes sobre o sexting e sobre o papel das relações familiares no fenômeno. Foram realizadas entrevistas semiestruturadas com seis adolescentes entre 14 e 17 anos de uma escola da região metropolitana de Porto Alegre, com ou sem envolvimento em sexting. A partir da análise de conteúdo, os resultados mostraram que o fenômeno foi descrito como comum e não negativo. Entretanto, os participantes o descreveram como problemático caso ocorra o compartilhamento não autorizado. O exemplo dos pais e o diálogo na família foram percebidos como influenciadores de sexting ativo. Sugere-se que educadores, pais e terapeutas não o qualifiquem pejorativamente. Também que ampliem a comunicação sobre sexualidade para além do caráter informativo, bem como a discussão dos riscos de exposição que o compartilhamento não autorizado do sexting acarreta.
INÍCIO DA MARCHA NA MIELOMENINGOCELE: UMA REVISÃO INTEGRATIVA.
Authors: Machado Francine Zillmer , Gerzson Laís Rodrigues , De Almeida Carla Skilhan 
Published: December 2019

Introdução: A mielomeningocele é uma má formação do sistema nervoso central, onde ocorre a falha do fechamento do tubo neural. Doença congênita, multifatorial, devido de deficiência de ácido fólico. Crianças com este diagnóstico podem apresentar dificuldades urológicas, ortopédicas, neurológicas, entre outras. A marcha pode iniciar em torno de dois anos de idade dificultando o aprendizado motor. Objetivo: Revisar na literatura atual o início da marcha independente e as intercorrências que podem acometer as crianças com mielomeningocele. Materiais e Métodos: Revisão integrativa. Foi realizada busca nas bases de dados PubMed, Lilacs, Scielo, Google Acadêmico, do início das bases até dezembro/2018. A busca compreendeu os descritores “open bífida spine” “myelomeningocele”, “gait”, “child” associados a seus termos sinônimos e seus equivalentes em inglês. Resultados: Encontrou-se 50 estudos, 35 foram selecionados para análise detalhada, após, oito foram incluídos na revisão. Os dados levantados pela grande maioria das pesquisas concluíram que o segmento mais afetado é a coluna lombar baixa. As intercorrências mais comuns foram úlceras de pressão, luxação de quadril, infecção urinária, fraturas e deformidades Conclusões: Todos os estudos relatam um início atrasado da marcha independente das crianças com MMC em relação às crianças típicas. O início vai depender do nível medular da lesão. A média encontrada foi três anos para lesão lombar baixa e quatro para a torácica. As alterações mais encontradas foram: escoliose, adução de quadril, joelhos fletidos, pés equinos e contraturas que estão relacionadas a assimetria da marcha, fraturas de fêmur e tíbia, luxações de quadril e deformidades nos pés.
Spatiotemporal complexity of chaos in a phase-conjugate feedback laser system
Authors: Malica Tushar , Bouchez Guillaume , Wolfersberger Delphine , Sciamanna Marc 
Published: December 2019

An 852 nm semiconductor laser is experimentally subjected to phase-conjugate time-delayed feedback achieved through four-wave mixing in a photorefractive (

B
a
T
i
O

3

) crystal. Permutation entropy (PE) is used to uncover distinctive temporal signatures corresponding to the sub-harmonics of the round-trip time and the relaxation oscillations. Complex spatiotemporal outputs with high PE mostly upwards of

∼
0.85

and chaos bandwidth (BW) up to

∼
31

G
H
z

are observed over feedback strengths up to 7%. The low-feedback region counterintuitively exhibits spatiotemporal reorganization, and the variation in the chaos BW is restricted within a small range of 1.66 GHz, marking the transition between the dynamics driven by the relaxation oscillations and the external cavity round-trip time. The immunity of the chaos BW and the complexity against such spatiotemporal reorganization show promise as an excellent candidate for secure communication applications.
CORRELATIONS BETWEEN PHYSICAL AND MENTAL LIFE QUALITY COMPONENTS WITH PSYCHOSOMATIC PARAMETERS IN WOMEN WORKING IN THE OIL INDUSTRY
Authors: Slyusar Ekaterina Nikolaeva , Govorukhina Alyona Anatolyevna 
Published: December 2019

Aim. The article deals with assessing professional risk factors and establishing the correlation between mental life quality components and psychosomatic parameters, which is a relevant issue of the psychophysiology of professional activity. Materials and methods. 102 female engineers participated in the study. All women belonged to two various age groups and possessed a different experience of living in the North. Obtaining the informed consent of all female participants was a mandatory requirement for inclusion in the study. MOS-SF-36 questionnaire was used for analyzing subjective assessment of physical and mental life quality components. Heart rate variability was studied with the VNS-spectrum equipment; body composition was analyzed with the VS-601 analyzer; the vascular wall was quantified with the Angioscan-01 device. Correlation analysis was conducted with the non-parametric Spearman coefficient. The level of significance was established at P < 0.05. The data obtained were processed with the Statistica v. 10.0 software. Results. It was revealed that adaptation to the climatic and ecological conditions of the North changed the character and number of intersystem correlations between mental life quality components and psychosomatic parameters. In young female engineers living in the North for less than 10 years, functional correlations between the physical function, pulse wave contour analysis data, and psychosomatic indicators were revealed. With the increase in the duration of living in northern conditions, the number of correlations with physical and mental life components decreased. Conclusion. The change in physical and mental life quality components during adaptation to northern conditions is determined by the physiological reactions of the body.
Keragaman Kondisi Salinitas Pada Lingkungan Tempat Tumbuh Mangrove di Teluk Kupang,NTT
Authors: Matatula Jeriels - 
Published: December 2019

Mangrove forest ecosystems are habitat of various types of microorganisms, but now, problems of mangrove forests experience are in quality and wealth. Efforts to rehabilitate activities mangrove forests againts had been carried out but the results shown had not been maximized, so it is need the correct strategies to achieve the success for rehabilitation activities. The studied was conducted in Teluk Kupang, East Nusa Tenggara, covered coastal areas of Kupang's mangrove forests and coastal mangrove forests in Kupang district. The method used in this studied was a systematic sampling method that was systematically distributed across all the mangrove forest areas. The method used for salinity measurement was method of transmission and Transect Line Plots. Measurements was made in straight line and the size of the plot is 10 m x 10 m, the distanced between lines was 50 meters so that total lane is 547 with the number of plots of observation 1641 plots. The value of measurement results was made into the spread of salinity used the interpolation method. The condition of the crossed of mangrove forest located on coastal panoramas of Kupang city shows a salinity value of 10,26 - 26.33%, while salinity conditions was on the coast of Kupang ten district 10-42.33 ‰. The salinity condition was formulation of the environmental conditions mangrove forest on coast of the island as well as attempts to support management of mangrove forest activities. The distribution of different mangrove forest conditions along the coastal zone of North Sumatra shows an environmental condition that supports mangrove growth even though in some places the salinity values are high. Results of this study of salinity conditions is a study of the environment of mangrove growth so that it can provide an overview for the government in conducting various activities to rehabilitate mangrove forests.
Integrations of Nation Beyond the Maritime Borders: Effort and Experience Malaysia In Strengthening and Developing Relationships with Indonesia
Authors: Samsudin Mohd Bin 
Published: December 2019

Malaysia inherited the legacy of the famous maritime empire of Srivijaya and Malacca Sultanate. Before western imperialism come, the Malay community in the region, especially in the Strait of Malacca enjoy a close relationship, regardless of borders. Historical experience binds the role and importance of maritime as a priority in realizing the relations between the people of Malaysia and Indonesia before the independence of the two countries which established inter-community interdependence. In fact, this interdependence that has enriched people's lives in economics and culture. Western colonialism had broken the ties of society when the borders were set up by them. But after the two countries became independent, there was an effort to re-establish a relationship based on historical and cultural experiences. Despite the experience of love and sorrow, the fact is that the priority to strengthen relations with Indonesia has never been forgotten by Malaysian leaders. Various efforts have been made in the field of economic, social,and cultural cooperation including IMT-GT. Communication and cultural cooperation between the two countries. The economic difficulties encountered during the financial crisis of the late 1990s, by sharing common experiences have strengthened leaders' confidence to prioritize intergenerational integration. Using the Collective Memory method, this paper will examinehistorical and cultural experiences as the basis for closer relationships. Furthermore, it will discuss Malaysia's efforts to strengthen and prosper the people of both countries through various means, especially ASEAN, IMT-GT economic development cooperation, SIJORI, inter-governmental cooperation, and inter-community cooperation that took place during Prime Minister Tun Abdul Razak's leadership and Tun Dr. Mahathir Mohamad.
Distinct Genetic Signatures of Cortical and Subcortical Regions Associated with Human Memory
Authors: Tan Pin Kwang , Ananyev Egor , Hsieh Po-Jang 
Published: December 2019

AbstractDespite the discovery of gene variants linked to memory performance, understanding the genetic basis of adult human memory remains a challenge. Here, we devised an unsupervised framework that relies on spatial correlations between human transcriptome data and functional neuroimaging maps to uncover the genetic signatures of memory in functionally-defined cortical and subcortical memory regions. Results were validated with animal literature and showed that our framework is highly effective in identifying memory-related processes and genes compared to a control cognitive function. Genes preferentially expressed in cortical memory regions are linked to memory-related processes such as immune and epigenetic regulation. Genes expressed in subcortical memory regions are associated with neurogenesis and glial cell differentiation. Genes expressed in both cortical and subcortical memory areas are involved in the regulation of transcription, synaptic plasticity, and glutamate receptor signaling. Furthermore, distinct memory-associated genes such asPRKCDandCDK5are linked to cortical and subcortical regions, respectively. Thus, cortical and subcortical memory regions exhibit distinct genetic signatures that potentially reflect functional differences in health and disease, and nominates gene candidates for future experimental investigations.
Costa Rica contemporánea, una sociedad dividida: empobrecimiento y movimientos sociales, una introducción
Authors: Agüero García Javier 
Published: December 2019

Este ensayo constituye una interpretación introductoria acerca del empobrecimiento y los movimientos sociales en Costa Rica, a partir de los años ochenta. Para la realización del análisis, se estudian los fenómenos de pauperización de los sectores medios, la proliferación de los nuevos pobres y las problemáticas vinculadas con la exclusión. En un segundo momento se abordan los movimientos sociales, a partir de las problemáticas que marcaron el período: la huelga de maestros en 1995, las protestas contra el Combo del ICE en 2000 y las manifestaciones masivas contra el TLC en 2006-2007. Bajo la perspectiva de la historia reciente, se consultan fuentes basadas en el Programa del Estado de la Nación, prensa escrita y textos ya publicados. Al final, se concluye en el reconocimiento de la compleja realidad social costarricense, caracterizada por el ensanchamiento de las brechas entre ricos y pobres; y el aumento del descontento expresado en las protestas callejeras.
The blackout (El apagón): El apocalipsis de las letras en un mundo digital. El cortometraje como propuesta didáctica de lectura y escritura en el aula de ELE.
Authors: Navarro Ayensa Mikel , Úcar Ventura Pilar 
Published: December 2019

Presentamos un análisis fílmico y lingüístico del cortometraje The blackout (El apagón) como propuesta metodológica para trabajar y desarrollar las competencias de lectura y escritura en el aula de idiomas, y en concreto, en el aula ELE. El objetivo consiste en aportar consignas para la intertextualidad de las imágenes y su plasmación en la expresión escrita.
De esta manera se consigue acercar las posibilidades que ofrece “el corto” a la enseñanza y aprendizaje de la lengua y la cultura a estudiantes en los niveles de educación secundaria y universitaria. La metodología que se emplea está basada en la descripción y comentario de escenas y actividades para implementar en el aula de una manera pragmática.
PENENTUAN RADIATIVE FORCING DARI KARBONDIOKSIDA (CO2) DAN METANA (CH4) DI GAW BUKIT KOTOTABANG SERTA HUBUNGANNYA DENGAN SUHU PERMUKAAN ATMOSFER DAN LAUT
Authors: Adhayani Noor Laily , Romadhon Syahru , Kepel Terry Louise 
Published: December 2019

Radiative Forcing didefinisikan sebagai perubahan jumlah energi radiasi yang masuk dan keluar di lapisan troposfer sehingga dapat menyatakan adanya gangguan yang merusak pola energi radiasi matahari, dengan laju perubahan energi per satuan luas, yang diukur di bagian atas atmosfer dan dinyatakan dalam satuan W/m2. RF dapat digunakan sebagai parameter untuk menunjukkan gejala dari fenomena perubahan iklim. Karbondioksida (CO2) dan Metana (CH4) merupakan gas rumah kaca utama di atmosfer. Eksistensi gas karbondioksida dan metana di atmosfer dapat terjadi akibat kegiatan manusia (antropogenik) dan alami (natural). Konsentrasi CO2 dan CH4 di GAW Kototabang dibandingkan dengan masa pra revolusi industri tahun 1750 diperoleh hasil bahwa terjadi peningkatan yang cukup signifikan. Peningkatan konsentrasi CO2 dan CH4 di atmosfer berturut-turut sebesar 41,05% dan 162,76%. Nilai RF CO2 dan CH4 pada periode pengukuran tahun 2004-2013 di GAW Bukit Kototabang cenderung mengalami tren naik setiap tahun dengan puncaknya terjadi pada akhir tahun 2013.