bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice-enhancing publications about the medication-use process in 2019
Authors: Vest Tyler A , Gazda Nicholas P , Schenkat Daniel H , Eckel Stephen F 
Published: October 2020

AbstractPurposeThis article identifies, prioritizes, and summarizes published literature on the medication-use process (MUP) from calendar year 2019 that can impact health-system pharmacy daily practice. The MUP is the foundational system that provides the framework for safe medication utilization within the healthcare environment. The MUP is defined in this article as having the following components: prescribing/transcribing, dispensing, administration, and monitoring. Articles that evaluated one of the steps were gauged for their usefulness in promoting daily practice change.SummaryA PubMed search was conducted in January 2020 for calendar year 2019 using targeted Medical Subject Headings keywords; in addition, searches of the table of contents of selected pharmacy journals were conducted. A total of 4,317 articles were identified. A thorough review identified 66 potentially practice-enhancing articles: 17 for prescribing/transcribing, 17 for dispensing, 7 for administration, and 25 for monitoring. Ranking of the articles for importance by peers led to the selection of key articles from each category. The highest-ranked articles are briefly summarized, with a mention of why each article is important within health-system pharmacy. The other articles are listed for further review and evaluation.ConclusionIt is important to routinely review the published literature and to incorporate significant findings into daily practice; this article assists in identifying and summarizing the most impactful recently published literature in this area. Health-system pharmacists have an active role in improving the MUP in their institution, and awareness of the significant published studies can assist in changing practice at the institutional level.
Responding to unforeseen disasters in a large health system
Authors: Hannan Ryan J , Lundholm Margaret K , Brierton Dennis , Chapman Noelle R M 
Published: October 2020

Abstract

Purpose
To describe how health systems may respond to sudden changes in operations by leveraging existing resources and to share one organization’s experience responding to the coronavirus disease (COVID-19) pandemic.

Summary
In a health system based in Illinois and Wisconsin, pharmacy services are provided by a single, integrated department responsible for all aspects of pharmaceutical care within the organization. Hospital, retail, ambulatory care, and population health services are all managed under one leadership team. All pertinent ancillary services are also managed within the department, including informatics, supply chain, and drug policy. During the COVID-19 pandemic, the pharmacy services leadership has successfully managed volume and capacity challenges by redirecting resources to where they are needed. A disaster response framework based on Federal Emergency Management Agency guidance was put in place, and change management principles were used to rapidly operationalize change. Components of the nimble response have included quickly increasing capacity, thoughtful and timely communication to all team members, strategic decision making with available data, creating an agile pool of labor, and maintaining an efficient system supply chain. Well-being and resilience are emphasized alongside reflection on lessons learned. Some changes made in the urgent response to the pandemic are being considered for long-term implementation.

Conclusion
Organizations have the potential to respond to almost any situation if they are integrated and teams work together to build flexibility. The keys to success are thoughtful maximization of existing resources and strong communication.
The Most Appropriate Lexical Unit for L2 Vocabulary Research and Pedagogy: A Brief Review of the Evidence
Authors: Brown Dale , Stoeckel Tim , Mclean Stuart , Stewart Jeff 
Published: October 2020

Abstract
The choice of lexical unit is a significant issue in L2 vocabulary research and pedagogy. This brief review examines two important questions bearing on this issue: (i) How encompassing a lexical unit can learners deal with receptively? and (ii) How much difference does the choice of lexical unit make in practice? Regarding the former, empirical evidence from studies with L2-English learners shows that the broad ‘word family’ unit, requiring considerable knowledge of affixes and the ability to apply this knowledge, cannot be supported. Regarding the latter, estimates of the proportion of English text consisting of derivational forms vary due to differences in approach and text type examined. However, even the smallest estimate is of a magnitude sufficient to have a meaningful impact on text comprehension. Accordingly, this review suggests that the most appropriate lexical unit may be the lemma or flemma. This conclusion has major implications for L2 vocabulary research, with regards to vocabulary testing and estimates of learning needs, and for L2 vocabulary pedagogy, in respect of curriculum planning and the use of word lists.
Taking the Test: A Qualitative Analysis of Cultural and Contextual Factors Impacting Neuropsychological Assessment of Xhosa-Speaking South Africans
Authors: Aghvinian Maral , Santoro Anthony F , Gouse Hetta , Joska John A , Linda Teboho , Thomas Kevin G F , Robbins Reuben N 
Published: October 2020

Abstract

Objective
There is an urgent need to make neuropsychological (NP) testing more acceptable, accessible, and culturally salient, particularly for culturally, educationally, and linguistically diverse individuals from countries who may have little-to-no experience with NP testing. In settings with limited resources such as South Africa, unique cultural and contextual factors (e.g., structural inequality, poverty) may impact the experience of NP evaluation. Research in this area is limited and requires further exploration. This qualitative study explores the role of cultural and contextual factors that may impact the experience of NP evaluation in a sample of Xhosa-speaking South African adults. Participant interviews explored the context from which individuals arrived at the NP assessment (e.g., quality of education, understanding of cognitive disorders), and their experience of completing NP tests.

Method
This qualitative study used data from semistructured interviews to conduct a thematic analysis exploring contextual factors and the experience of completing NP tests for the first time among Xhosa-speaking South African adults (N = 22). Results: Although no participants had prior experience with NP testing, most found testing procedures acceptable. Most participants, however, reported a limited understanding of the purpose of NP testing and cognitive problems. Additionally, some participants reported perceptions and attitudes that could affect test performance, such as misinterpreting standard testing procedures (e.g., no feedback from the examiner, being stopped mid-task) as indicative of poor performance.

Conclusions
This study provided much needed exploration into unique cultural factors that may impact the experience of NP assessment in South Africa, which could bias test performance and interpretation, and may aid the field of cross-cultural NP in better serving culturally and linguistically diverse populations. In these countries, neuropsychologists may need to actively evaluate participants’ understanding of NP testing to help foster optimal assessment conditions. They may also need to educate participants on possible causes of cognitive disorders.
Plants will cross the lines: climate and available land mass are the major determinants of phytogeographical patterns in the Sunda–Sahul Convergence Zone
Authors: Joyce Elizabeth M , Thiele Kevin R , Slik J W Ferry , Crayn Darren M 
Published: October 2020

AbstractThe Miocene convergence of the Sunda shelf, Sahul shelf and Wallacea facilitated the exchange of previously isolated floras across the Sunda–Sahul Convergence Zone (SSCZ). The SSCZ is a hotspot of biogeographical research; however, phytogeographical patterns across the region remain poorly understood. We conducted multivariate analysis on a comprehensive species checklist of SSCZ vascular plants to quantify the extent of exchange, characterize phytogeographical patterns and investigate their abiotic drivers. We found that Lydekker’s and Wallace’s Lines are not reflected in floristic composition at any taxonomic level, with 46% of genera distributed across these biogeographical lines. In contrast, environment is significantly correlated with floristic composition, with annual rainfall and seasonality being the strongest correlates. Mainland Asia, Borneo, the Philippines, New Guinea and Australia were major routes of exchange throughout the Cenozoic, possibly because these areas have been persistent landmasses throughout the entire period of convergence. We conclude that Sunda–Sahul floristic exchange has substantially influenced the assembly of the regional flora and that modern phytogeographical patterns have been influenced more by environmental variables and available landmass (i.e. establishment conditions) than by putative barriers to movement such as Wallace’s and Lydekker’s Lines (i.e. vagility).
‘There’s A Certain Group of Cops that have their Own Vendetta’: Resident Perceptions of Notorious Police Officers and ‘Cop Clockin’ in the Inner-City
Authors: Urbanik Marta-Marika , Greene Carolyn , Wojnarowicz Jake 
Published: October 2020

Abstract
Many inner-city neighbourhoods across North America are disproportionately subject to heightened and aggressive policing strategies. Consequently, many inner-city residents have developed strategies to limit their encounters with police. Research examining police–community relationships has traditionally examined how residents perceive and respond to ‘the police’. However, this homogenizes and over-simplifies nuanced processes. Based upon 48 interviews with Toronto inner-city residents, we demonstrate how narratives about allegedly ‘notorious’ officers reveal that residents differentiate between individual officers and modify their behaviours accordingly. This process of officer differentiation—‘cop clockin’—results in strategic responses to specific officers as residents attempt to hinder the potential harms of interactions with ‘notorious cops’. Furthermore, officer complacency raises questions about police legitimacy and strengthening police–community relationships.
DNA hypermethylation of the ZNF132 gene participates in the clinicopathological aggressiveness of ‘pan-negative’-type lung adenocarcinomas
Authors: Hamada Kenichi , Tian Ying , Fujimoto Mao , Takahashi Yoriko , Kohno Takashi , Tsuta Koji , Watanabe Shun-ichi , Yoshida Teruhiko , Asamura Hisao , Kanai Yae , Arai Eri 
Published: October 2020

Abstract
Although some previous studies have examined epigenomic alterations in lung adenocarcinomas, correlations between epigenomic events and genomic driver mutations have not been fully elucidated. Single-CpG resolution genome-wide DNA methylation analysis with the Infinium HumanMethylation27 BeadChip was performed using 162 paired samples of adjacent normal lung tissue (N) and the corresponding tumorous tissue (T) from patients with lung adenocarcinomas. Correlations between DNA methylation data on the one hand and clinicopathological parameters and genomic driver mutations, i.e. mutations of EGFR, KRAS, BRAF and HER2 and fusions involving ALK, RET and ROS1, were examined. DNA methylation levels in 12 629 probes from N samples were significantly correlated with recurrence-free survival. Principal component analysis revealed that distinct DNA methylation profiles at the precancerous N stage tended not to induce specific genomic driver aberrations. Most of the genes showing significant DNA methylation alterations during transition from N to T were shared by two or more driver aberration groups. After small interfering RNA knockdown of ZNF132, which showed DNA hypermethylation only in the pan-negative group and was correlated with vascular invasion, the proliferation, apoptosis and migration of cancer cell lines were examined. ZNF132 knockdown led to increased cell migration ability, rather than increased cell growth or reduced apoptosis. We concluded that DNA hypermethylation of the ZNF132 gene participates in the clinicopathological aggressiveness of ‘pan-negative’ lung adenocarcinomas. In addition, DNA methylation alterations at the precancerous stage may determine tumor aggressiveness, and such alterations that accumulate after driver mutation may additionally modify clinicopathological features through alterations of gene expression.
Human Brain Ages With Hierarchy-Selective Attenuation of Prediction Errors
Authors: Hsu Yi-Fang , Waszak Florian , Strömmer Juho , Hämäläinen Jarmo A 
Published: October 2020

Abstract
From the perspective of predictive coding, our brain embodies a hierarchical generative model to realize perception, which proactively predicts the statistical structure of sensory inputs. How are these predictive processes modified as we age? Recent research suggested that aging leads to decreased weighting of sensory inputs and increased reliance on predictions. Here we investigated whether this age-related shift from sensorium to predictions occurs at all levels of hierarchical message passing. We recorded the electroencephalography responses with an auditory local–global paradigm in a cohort of 108 healthy participants from 3 groups: seniors, adults, and adolescents. The detection of local deviancy seems largely preserved in older individuals at earlier latency (including the mismatch negativity followed by the P3a but not the reorienting negativity). In contrast, the detection of global deviancy is clearly compromised in older individuals, as they showed worse task performance and attenuated P3b. Our findings demonstrate that older brains show little decline in sensory (i.e., first-order) prediction errors but significant diminution in contextual (i.e., second-order) prediction errors. Age-related deficient maintenance of auditory information in working memory might affect whether and how lower-level prediction errors propagate to the higher level.
Transfer of Odor Perception From the Retronasal to the Orthonasal Pathway
Authors: He Rui , Dukes Talicia C , Kay Leslie M 
Published: October 2020

Abstract
Although orthonasal odorants are often associated with the external environment, retronasal odorants are accompanied by consummatory behaviors and indicate an internal state of an animal. Our study aimed to examine whether the same odorants may generate a consistent perceptual experience when 2 olfactory routes potentiate variations in concentration in the nasal cavity and orosensory activation. A customized lick spout with vacuum removing odorants around the animal’s nares was used to render a pure retronasal exposure experience. We found that pre-exposing rats to odorants retronasally with positive or negative reinforcers (sweet or bitter) lead to a significant learning rate difference between high- and low-vapor-pressure odorants. This effect was not observed for novel odorants, suggesting that odorants may generate similar perceptual quality in a volatility-dependent manner.
Invasive Pneumococcal Strain Distributions and Isolate Clusters Associated With Persons Experiencing Homelessness During 2018
Authors: Metcalf Benjamin J , Chochua Sopio , Walker Hollis , Tran Theresa , Li Zhongya , Varghese Jasmine , Snippes Vagnone Paula M , Lynfield Ruth , McGee Lesley , Li Yuan , Pilishvili Tamara , Beall Bernard 
Published: October 2020

Abstract

Background
We aimed to characterize invasive pneumococcal disease (IPD) isolates collected from multistate surveillance in the United States during 2018 and examine within-serotype propensities of isolates to form related clusters.

Methods
We predicted strain features using whole genome sequencing obtained from 2885 IPD isolates obtained through the Center for Disease Control and Prevention’s Active Bacterial Core surveillance (ABCs), which has a surveillance population of approximately 34.5 million individuals distributed among 10 states. Phylogenetic analysis was provided for serotypes accounting for ≥27 isolates.

Results
Thirteen-valent pneumococcal conjugate vaccine (PCV13) serotypes together with 6C accounted for 23 of 105 (21.9%) of isolates from children aged &lt;5 years and 820 of 2780 (29.5%) isolates from those aged ≥5 years. The most common serotypes from adult IPD isolates were serotypes 3 (413/2780 [14.9%]), 22F (291/2780 [10.5%]), and 9N (191/2780 [6.9%]). Among child IPD isolates, serotypes 15BC (18/105 [17.1%]), 3 (11/105 [10.5%]), and 33F (10/105 [9.5%]) were most common. Serotypes 4, 12F, 20, and 7F had the highest proportions of isolates that formed related clusters together with the highest proportions of isolates from persons experiencing homelessness (PEH). Among 84 isolates from long-term care facilities, 2 instances of highly related isolate pairs from co-residents were identified.

Conclusions
Non-PCV13 serotypes accounted for &gt;70% of IPD in ABCs; however, PCV13 serotype 3 is the most common IPD serotype overall. Serotypes most common among PEH were more often associated with temporally related clusters identified both among PEH and among persons not reportedly experiencing homelessness.
Coronavirus Disease 2019 (COVID-19) Seropositivity and Asymptomatic Rates in Healthcare Workers Are Associated with Job Function and Masking
Authors: Sims Matthew D , Maine Gabriel N , Childers Karen Lins , Podolsky Robert H , Voss Daniel R , Berkiw-Scenna Natalie , Oh Joyce , Heinrich Kevin E , Keil Hans , Kennedy Richard H , Homayouni Ramin 
Published: October 2020

AbstractBackgroundAlthough the risk of exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is higher for frontline healthcare workers, not all personnel have similar risks. Determining infection rate is difficult due to the limits on testing and the high rate of asymptomatic individuals. Detection of antibodies against SARS-CoV-2 may be useful for determining prior exposure to the virus and assessing mitigation strategies, such as isolation, masks, and other protective equipment.MethodsAn online assessment that included demographic, clinical, and exposure information and a blood sample was collected from 20 614 participants out of ~43 000 total employees at Beaumont Health, which includes 8 hospitals distributed across the Detroit metropolitan area in southeast Michigan. The presence of anti-SARS-CoV-2 IgG was determined using the EUROIMMUN assay.ResultsA total of 1818 (8.8%) participants were seropositive between April 13 and May 28, 2020. Among the seropositive individuals, 44% reported that they were asymptomatic during the month prior to blood collection. Healthcare roles such as phlebotomy, respiratory therapy, and nursing/nursing support exhibited significantly higher seropositivity. Among participants reporting direct exposure to a Coronavirus Disease 2019 (COVID-19) positive individual, those wearing an N95/PAPR mask had a significantly lower seropositivity rate (10.2%) compared to surgical/other masks (13.1%) or no mask (17.5%).ConclusionsDirect contact with COVID-19 patients increased the likelihood of seropositivity among employees but study participants who wore a mask during COVID-19 exposures were less likely to be seropositive. Additionally, a large proportion of seropositive employees self-reported as asymptomatic. (Funded by Beaumont Health and by major donors through the Beaumont Health Foundation)ClinicalTrials.gov numberNCT04349202
Dysbiosis in marine aquaculture revealed through microbiome analysis: reverse ecology for environmental sustainability
Authors: Haro-Moreno Jose M , Coutinho Felipe Hernandes , Zaragoza-Solas Asier , Picazo Antonio , Almagro-Moreno Salvador , López-Pérez Mario 
Published: October 2020

AbstractThe increasing demand for products for human consumption is leading to the fast-growing expansion of numerous food sectors such as marine aquaculture (mariculture). However, excessive input of nutrients and pollutants modifies marine ecosystems. Here, we applied a metagenomic approach to investigate these perturbations in samples from marine farms of gilthead seabream cultures. Results revealed dysbiosis and functional imbalance within the net cage with a unique structure, with little interference with samples from the fish microbiota or those collected far away from the coast. Remarkably, below the cage the prokaryotic community was highly similar to the marine microbiome of photic offshore samples. We recovered 48 novel metagenome-assembled genomes. Metagenomic recruitment revealed a significant change in the microbial community which was dominated by several Proteobacteria orders (Sphingomonadales, Pseudomonadales, Caudobacterales and Rhizobiales). Genomic potential for bioremediation processes, including nitrate removal through aerobic denitrification, and degradation of aromatic compounds and other toxic products were enriched in these microbes. The detrimental side effects were the increased number of antimicrobial resistance genes and the presence of potentially emergent pathogens. Knowledge of this metabolic diversity and the microbes involved in ecological balance recovery can be used to reduce the environmental impact of these practices.
Transcriptional analysis of metabolic and virulence genes associated with biofilm formation in Piscirickettsia salmonis strains
Authors: Zúñiga A , Solis C , Cartes C , Nourdin G , Yañez A , Romero A , Haussmann D , Figueroa J 
Published: October 2020

ABSTRACT
Piscirickettsia salmonis is a facultative intracellular bacterium that generates piscirickettsiosis affecting salmonids in Chile. The bacterium has the adaptability to survive in the marine environment under multiple stressful conditions. In this sense, this work focused on the analysis of a gene battery associated with biofilm formation under different culture conditions and on the adaptability of this biofilm to different media. The results indicated that the strains LF-89, IBM-034 and IBM-040 were strong biofilm producers, evidencing adaptability to the media by increasing the amount of biofilm through successive growths. Transcript levels of six genes described in various bacteria and P. salmonis, considered to have metabolic functions, and playing a relevant role in biofilm formation, were analyzed to evaluate bacterial functionality in the biofilm. The genes mazE-mazF, implicated in biofilm and stress, were markedly overexpressed in the biofilm condition in the three strains. For its part, gene gltA, an indicator of metabolic activity and related to virulence inhibition in Salmonella typhimurium, also seems to restrain the pathogenesis process in P. salmonis by inhibiting the expression of the virulence-associated genes liso and tcf. Finally, the expression of the glnA gene suggests the use of glutamine as an essential element for the growth of the biofilm.