bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney Function and Potassium Monitoring After Initiation of Renin-Angiotensin-Aldosterone System Blockade Therapy and Outcomes in 2 North American Populations
Authors: Parikh Rishi V. , Nash Danielle M. , Brimble K. Scott , Markle-Reid Maureen , Tan Thida C. , McArthur Eric , Khoshniat-Rad Farzien , Sood Manish M. , Zheng Sijie , Pravoverov Leonid , Nesrallah Gihad E. , Garg Amit X. , Go Alan S. 
Published: September 2020

Background:
Clinical practice guidelines recommend routine kidney function and serum potassium testing within 30 days of initiating ACE (angiotensin-converting enzyme) inhibitor or angiotensin II receptor blocker therapy. However, evidence is lacking about whether follow-up testing reduces therapy-related adverse outcomes.

Methods and Results:
We conducted 2 population-based retrospective cohort studies in Kaiser Permanente Northern California and Ontario, Canada. Patients with outpatient serum creatinine and potassium tests in the 30 days after starting ACE inhibitor or angiotensin II receptor blocker therapy were matched 1:1 to patients without follow-up tests. We evaluated the association of follow-up testing with 30-day all-cause mortality and hospitalization with acute kidney injury or hyperkalemia using Cox regression. We also developed and externally validated a risk score to identify patients at risk of having abnormally high serum creatinine and potassium values in follow-up. We identified 75 251 matched pairs initiating ACE inhibitor or angiotensin II receptor blocker therapy between January 1, 2007, and December 31, 2017, in Kaiser Permanente Northern California. Follow-up testing was not significantly associated with 30-day all-cause mortality in Kaiser Permanente Northern California (hazard ratio, 0.75 [95% CI, 0.54–1.06]) and was associated with higher mortality in 84 905 matched pairs in Ontario (hazard ratio, 1.32 [95% CI, 1.07–1.62]). In Kaiser Permanente Northern California, follow-up testing was significantly associated with higher rates of hospitalization with acute kidney injury (hazard ratio, 1.66 [95% CI, 1.10–2.22]) and hyperkalemia (hazard ratio, 3.36 [95% CI, 1.08–10.41]), as was observed in Ontario. The risk score for abnormal potassium provided good discrimination (area under the curve [AUC], 0.75) and excellent calibration of predicted risks, while the risk score for abnormal serum creatinine provided moderate discrimination (AUC, 0.62) but excellent calibration.

Conclusions:
Routine laboratory monitoring after ACE inhibitor or angiotensin II receptor blocker initiation was not associated with a lower risk of 30-day mortality. We identified patient subgroups in which targeted testing may be effective in identifying therapy-related changes in serum potassium or kidney function.
Past Sodium Intake, Contemporary Sodium Intake, and Cardiometabolic Health in Southwest Coastal Bangladesh
Authors: Naser Abu Mohd , Rahman Mahbubur , Unicomb Leanne , Doza Solaiman , Selim Shahjada , Chaity Monjila , Luby Stephen P. , Anand Shuchi , Staimez Lisa , Clasen Thomas F. , Gujral Unjali P. , Gribble Matthew O. , Narayan K. M. Venkat 
Published: September 2020

Background
We compared the relationship of past and contemporary sodium (Na) intake with cardiometabolic biomarkers.

Methods and Results
A total of 1191 participants' data from a randomized controlled trial in coastal Bangladesh were analyzed. Participants provided 24‐hour urine Na (24UNa) data for 5 monthly visits. Their fasting blood glucose, total cholesterol, triglycerides, high‐density lipoprotein, blood pressure, and 24‐hour urine protein were measured at the fifth visit. Participants' mean 24UNa over the first 4 visits was the past Na, and 24UNa of the fifth visit was the contemporary Na intake. We estimated the prevalence ratios of elevated cardiometabolic biomarkers and metabolic syndrome across 24UNa tertiles by multilevel logistic regression using participant‐, household‐, and community‐level random intercepts. Models were adjusted for age, sex, body mass index, smoking, physical activity, alcohol consumption, sleep hours, religion, and household wealth. Compared with participants in tertile 1 of past urine Na, those in tertile 3 had 1.46 (95% CI, 1.08–1.99) times higher prevalence of prediabetes or diabetes mellitus, 5.49 (95% CI, 2.73–11.01) times higher prevalence of large waist circumference, and 1.60 (95% CI, 1.04–2.46) times higher prevalence of metabolic syndrome. Compared with participants in tertile 1 of contemporary urine Na, those in tertile 3 had 1.93 (95% CI, 1.24–3.00) times higher prevalence of prediabetes or diabetes mellitus, 3.14 (95% CI, 1.45–6.83) times higher prevalence of proteinuria, and 2.23 (95% CI, 1.34–3.71) times higher prevalence of large waist circumference.

Conclusions
Both past and contemporary Na intakes were associated with higher cardiometabolic disease risk.
Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy
Authors: Gauer Simon , Balint Brittany , Kollmann Catherine , Federspiel Jan M. , Henn Dominic , Bandner‐Risch Doris , Schmied Wolfram , Schäfers Hans‐Joachim 
Published: September 2020

Background
Bicuspid aortic valves (BAVs) predispose to ascending aortic aneurysm. Turbulent blood flow and genetic factors have been proposed as underlying mechanisms. Endothelial nitric oxide synthase (eNOS) has been implicated in BAV aortopathy, and its expression is regulated by wall shear stress. We hypothesized that if turbulent flow induces aneurysm formation in patients with a BAV, regional differences in eNOS expression would be observed in BAVs.

Methods and Results

Ascending aortic specimens were harvested intraoperatively from 48 patients with tricuspid aortic valve (19 dilated, 29 nondilated) and 38 with BAV (28 dilated, 10 nondilated) undergoing cardiac surgery. eNOS mRNA and protein concentration were analyzed at the convex and concave aortic wall. In nondilated aortas, eNOS mRNA and protein concentration were decreased in BAV compared with tricuspid aortic valve (all
P
<0.05). eNOS expression was increased in association with dilation in BAV aortas (
P
=0.03), but not in tricuspid aortic valve aortas (
P
=0.63). There were no regional differences in eNOS mRNA or protein concentration in BAV aortas (all
P
>0.05). However, eNOS expression was increased at the concave wall (versus convexity) in tricuspid aortic valve dilated aortas (all
P
<0.05).

Conclusions
Dysregulated eNOS occurs independent of dilation in BAV aortas, suggesting a potential role for aberrantly regulated eNOS expression in the development of BAV‐associated aneurysms. The absence of regional variations of eNOS expression suggests that eNOS dysregulation in BAV aortas is the result of underlying genetic factors associated with BAV disease, rather than changes stimulated by hemodynamic alterations. These findings provide insight into the underlying mechanisms of aortic dilation in patients with a BAV.
Suppression of the soybean cyst nematode, Heterodera glycines, by short-term field cultivation and soil incorporation of mung bean
Authors: Chikamatsu Seiya , Takeda Ai , Ohta Kazuhiro , Imura Takeo , Perry Roland N. , Toyota Koki 
Published: September 2020

Summary
Our previous study using pots reported that short-term growth of mung bean (Vigna radiata) may be useful to decrease the density of the soybean cyst nematode (SCN), Heterodera glycines, in soil. The objective of this study was to determine whether short-term growth of mung bean and its incorporation by ploughing decreased SCN density in infested fields. Firstly, we did pot experiments to evaluate the optimum temperature and moisture for hatching in soil. SCN hatching was stimulated at 25 and 30°C and not at 20°C; however, it was stimulated at alternating temperature conditions between 20 and 25°C. Soil moisture levels with pF 2.76 or less were required to stimulate SCN hatch in soil. Field experiments were done in Saitama, Kanagawa and Nara Prefectures, Japan. SCN density was reduced by nearly half even in control plots, in which mung bean was not cultivated and ploughed, in Saitama and Nara Prefectures. However, SCN density was reduced by nearly 80% or more in the three Prefectures, except for one plot in Kanagawa, and the soil temperature and moisture conditions were kept at around 20-30°C and at <pF 2.8. Increase in yield of green soybean by SCN control was estimated at 350 kg (1000 m)−2. Overall, the present study revealed that short-term field cultivation of mung bean and ploughing was a profitable method to decrease SCN density in infested fields and thereby to increase yield of green soybean.
Ultrastructural observations of spermatogenesis in the fungivorous nematode Paraphelenchus myceliophthorus Goodey, 1958 (Rhabditida: Aphelenchoidea, Aphelenchidae)
Authors: Yushin Vladimir V. , Ryss Alexander 
Published: September 2020

Summary
Spermatogenesis in Paraphelenchus myceliophthorus is similar to that of the ‘rhabditid’ nematodes. The sperm development includes formation of complexes of fibrous bodies (FB) and membranous organelles (MO), which appear in spermatocytes; the complexes dissociate in the spermatids and the immature sperm contains separate FB and MO. Mature spermatozoa from the uterus are bipolar cells subdivided into anterior pseudopod and posterior main cell body containing a nucleus without a nuclear envelope, numerous mitochondria and peripheral MO opening to the exterior via pores. The mature spermatozoa in the uterus form chains of more than ten flattened cells. Spermatogenesis characters, such as nuclear satellites, presence of FB in immature spermatozoa, small knobbles of MO, specific dense inclusions, absence of filopodia and sperm conjugation, make spermatozoa of P. myceliophthorus morphologically specific for comparative analysis with representatives of Aphelenchoidea and other rhabditids.
Risk of Occurrence of Water Deficit in Soybean Cultivated in Lowland Soils
Authors: Bortoluzzi Mateus Possebon , Heldwein Arno Bernardo , Trentin Roberto , Maldaner Ivan Carlos , Rosa da Silva Jocélia 
Published: September 2020

AbstractThe occurrence of water deficit is intensified in lowland soils. Generating information with regard to its risk of occurrence is essential to avoid seed yield losses. The objective of this study was to determine the probability of water deficit in soybean cultivated in lowlands of the Vacacaí and Piratini River basins in the southern portion of Rio Grande do Sul in Brazil as a function of the sowing date. Soybean development was simulated considering three sets of cultivars of relative maturity groups (RMG) delimited by 5.9–6.8, 6.9–7.3, and 7.4–8.0, with a 10-day interval between the sowing dates making up the period between 21 September and 31 December. Daily meteorological data were used from 1971 to 2017 obtained from the Pelotas meteorological station and from 1968 to 2017 from the Santa Maria meteorological station. Water deficit (mm) in the subperiods and soybean development cycle was obtained from the calculation of evapotranspiration and daily sequential crop water balance. Data of water deficit were subjected to a probability distribution analysis, in which the exponential, gamma, lognormal, normal, and Weibull probability density function (pdf) adjustments were tested using chi-square and Kolmogorov–Smirnov adhesion tests, with a 10% significance level. The water deficit is lower in the Pelotas region than in Santa Maria. Sowings performed from 11 and 1 November present the lowest risk of occurrence of water deficit throughout the soybean cycle in Santa Maria and Pelotas, respectively. Risk of water deficit decreases for the beginning of flowering–beginning of seed (R1–R5) subperiod when soybean sowing occurs from the beginning of November.
Updraft Vertical Velocity Observations and Uncertainties in High Plains Supercells Using Radiosondes and Radars
Authors: Marinescu Peter J. , Kennedy Patrick C. , Bell Michael M. , Drager Aryeh J. , Grant Leah D. , Freeman Sean W. , van den Heever Susan C. 
Published: September 2020

AbstractObservations of the air vertical velocities (wair) in supercell updrafts are presented, including uncertainty estimates, from radiosonde GPS measurements in two supercells. These in situ observations were collected during the Colorado State University Convective Cloud Outflows and Updrafts Experiment (C3LOUD-Ex) in moderately unstable environments in Colorado and Wyoming. Based on the radiosonde accelerations, instances when the radiosonde balloon likely bursts within the updraft are determined, and adjustments are made to account for the subsequent reduction in radiosonde buoyancy. Before and after these adjustments, the maximum estimated wair values are 36.2 and 49.9 m s−1, respectively. Radar data are used to contextualize the in situ observations and suggest that most of the radiosonde observations were located several kilometers away from the most intense vertical motions. Therefore, the radiosonde-based wair values presented likely underestimate the maximum values within these storms due to these sampling biases, as well as the impacts from hydrometeors, which are not accounted for. When possible, radiosonde-based wair values were compared to estimates from dual-Doppler methods and from parcel theory. When the radiosondes observed their highest wair values, dual-Doppler methods generally produced 15–20 m s−1 lower wair for the same location, which could be related to the differences in the observing systems’ resolutions. In situ observations within supercell updrafts, which have been limited in recent decades, can be used to improve our understanding and modeling of storm dynamics. This study provides new in situ observations, as well as methods and lessons that could be applied to future field campaigns.
Understanding Error Distributions of Hurricane Intensity Forecasts during Rapid Intensity Changes
Authors: Trabing Benjamin C. , Bell Michael M. 
Published: September 2020

AbstractThe characteristics of official National Hurricane Center (NHC) intensity forecast errors are examined for the North Atlantic and east Pacific basins from 1989 to 2018. It is shown how rapid intensification (RI) and rapid weakening (RW) influence yearly NHC forecast errors for forecasts between 12 and 48 h in length. In addition to being the tail of the intensity change distribution, RI and RW are at the tails of the forecast error distribution. Yearly mean absolute forecast errors are positively correlated with the yearly number of RI/RW occurrences and explain roughly 20% of the variance in the Atlantic and 30% in the east Pacific. The higher occurrence of RI events in the east Pacific contributes to larger intensity forecast errors overall but also a better probability of detection and success ratio. Statistically significant improvements to 24-h RI forecast biases have been made in the east Pacific and to 24-h RW biases in the Atlantic. Over-ocean 24-h RW events cause larger mean errors in the east Pacific that have not improved with time. Environmental predictors from the Statistical Hurricane Intensity Prediction Scheme (SHIPS) are used to diagnose what conditions lead to the largest RI and RW forecast errors on average. The forecast error distributions widen for both RI and RW when tropical systems experience low vertical wind shear, warm sea surface temperature, and moderate low-level relative humidity. Consistent with existing literature, the forecast error distributions suggest that improvements to our observational capabilities, understanding, and prediction of inner-core processes is paramount to both RI and RW prediction.
The Role of Management Accountants in Information Strategy
Authors: Kaye G Roland 
Published: September 2020

This paper is concerned with the emerging role of management accountants in the formulation, development and implementation of information strategies within organizations. The paper is both empirical in that it is based on survey data and theoretical as it postulates future developments. The essence of the argument is that management accountants have adapted to information technology and have been active in exploiting data processing systems since their inception. This experience and knowledge of the technology alongside their managerial abilities form powerful tools to enable their participation in developing information strategies. The development of an information strategy enables the matching of technology, information content and managerial activity to achieving the overall business strategy in the face of uncertainty. This clearly follows the proposal of accounting process to manage environmental uncertainty reflecting Lorange and Scott-Morton (1974), Hedberg and Jonsson (1978), Hedberg al. (1976) and Earl (1983).
Disparities in the use of regular pap smears among migrant and non-migrant women in Austria: A population-based survey of 7633 women
Authors: Brzoska Patrick , Aksakal Tugba , Yilmaz-Aslan Yüce 
Published: September 2020

Objective: Regular pap smears are effective in reducing cervical cancer incidence and mortality. Migrant women have been reported to utilize cervical cancer screening less often than non-migrant women. However, inconsistent results, e.g. from Germany, have also been reported. This study examines disparities in the use of annual pap smears among 20–69 year old migrant and non-migrant women in neighboring Austria. Method: Data from a nationwide population-based survey of 7633 women is used of whom 504 (6.6%) were migrants from European Union countries and 251 (3.3%) were migrants from non-European Union countries. Logistic regression analysis was conducted to account for socio economic and health differences between the three population groups. Results: The study shows that as compared to the non-migrant women, migrant women from European Union and non-European Union countries were at lower odds of having received a pap smear in the last 12 months (adjusted odds ratio  = 0.80, 95% confidence interval = 0.66–0.96 and adjusted odds ratio = 0.74, 95%-confidence interval = 0.57–0.97, respectively). Disparities were similar with respect to utilization in the last 36 months (adjusted odds ratio = 0.60, 95% confidence interval = 0.46–0.77 and adjusted odds ratio = 0.58, 95% confidence interval = 0.40–0.82, respectively). Conclusion: The findings are in agreement with research from the majority of other countries. They suggest barriers that migrants encounter in the health system and highlight the need for diversity-sensitive health care strategies.
Serpiginous Choroiditis Presenting in Association With Clostridium difficile Infection and Ulcerative Colitis
Authors: Pollmann André S. , Mishra Amit V. , Betsch Devin M. , Francisconi Carolina L. M. 
Published: September 2020

Purpose: This work reports a case of serpiginous choroiditis (SC) in association with ulcerative colitis and Clostridium difficile infection. Methods: A case report is discussed. Results: A 35-year-old man with a history of ulcerative colitis and recently treated C difficile infection presented with a rapid decline in central visual acuity in both eyes. Examination findings included geographic creamy-white lesions extending from the peripapillary region in both eyes. Multimodal imaging and negative infectious workup results supported the diagnosis of SC. Visual acuity and examination findings improved after initiation of systemic prednisone therapy. Adalimumab was initiated as a steroid-sparing treatment. At the last follow-up, 5 months after the initial presentation, SC and ulcerative colitis both remain in remission. Conclusions: SC has been previously described in patients with systemic disorders, including autoimmune conditions. This patient developed SC following C difficile infection and in the context of active ulcerative colitis. To our knowledge, this is the first report of SC in association with these entities.
How I treat nodular lymphocyte-predominant Hodgkin lymphoma
Authors: Eichenauer Dennis A. , Engert Andreas 
Published: September 2020

Abstract
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity with distinct pathologic and clinical characteristics. Unlike the malignant cells in classical Hodgkin lymphoma, the disease-defining lymphocyte-predominant cells in NLPHL are consistently positive for CD20, but do not express CD30. The clinical course of NLPHL is indolent in the majority of cases. Most patients present with early-stage disease at the initial diagnosis. First-line treatment of stage IA NLPHL usually consists of limited-field radiotherapy alone. Patients with early-stage NLPHL other than stage IA and intermediate-stage disease mostly receive combined-modality treatment, whereas individuals with advanced NLPHL are treated with chemotherapy alone. In relapsed NLPHL, conventional chemotherapy, anti-CD20 antibodies, and radiotherapy represent active treatment modalities. Only patients with poor-risk characteristics such as early disease recurrence are candidates for aggressive salvage treatment with high-dose chemotherapy and autologous stem cell transplantation. The overall and relative survival of patients with NLPHL is excellent as indicated by a low excess mortality compared with the general population. This article discusses treatment options for patients with NLPHL and factors that influence the choice of therapy on the basis of the available data and 2 clinical cases.
Phase 1/2a study of 177Lu-lilotomab satetraxetan in relapsed/refractory indolent non-Hodgkin lymphoma
Authors: Kolstad Arne , Illidge Tim , Bolstad Nils , Spetalen Signe , Madsbu Ulf , Stokke Caroline , Blakkisrud Johan , Løndalen Ayca , O'Rourke Noelle , Beasley Matthew , Jurczak Wojciech , Fagerli Unn-Merete , Kaščák Michal , Bayne Mike , Obr Aleš , Dahle Jostein , Rojkjaer Lisa , Pascal Veronique , Holte Harald 
Published: September 2020

AbstractFor patients with indolent non-Hodgkin lymphoma who fail initial anti-CD20–based immunochemotherapy or develop relapsed or refractory disease, there remains a significant unmet clinical need for new therapeutic approaches to improve outcomes and quality of life. 177Lu-lilotomab satetraxetan is a next-generation single-dose CD37-directed radioimmunotherapy (RIT) which was investigated in a phase 1/2a study in 74 patients with relapsed/refractory indolent non-Hodgkin B-cell lymphoma, including 57 patients with follicular lymphoma (FL). To improve targeting of 177Lu-lilotomab satetraxetan to tumor tissue and decrease hematologic toxicity, its administration was preceded by the anti-CD20 monoclonal antibody rituximab and the “cold” anti-CD37 antibody lilotomab. The most common adverse events (AEs) were reversible grade 3/4 neutropenia (31.6%) and thrombocytopenia (26.3%) with neutrophil and platelet count nadirs 5 to 7 weeks after RIT. The most frequent nonhematologic AE was grade 1/2 nausea (15.8%). With a single administration, the overall response rate was 61% (65% in patients with FL), including 30% complete responses. For FL with ≥2 prior therapies (n = 37), the overall response rate was 70%, including 32% complete responses. For patients with rituximab-refractory FL ≥2 prior therapies (n = 21), the overall response rate was 67%, and the complete response rate was 24%. The overall median duration of response was 13.6 months (32.0 months for patients with a complete response). 177Lu-lilotomab satetraxetan may provide a valuable alternative treatment approach in relapsed/refractory non-Hodgkin lymphoma, particularly in patients with comorbidities unsuitable for more intensive approaches. This trial was registered at www.clinicaltrials.gov as #NCT01796171.