bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tradition and Fermentation Science of prohok, an ethnic fermented fish product of Cambodia
Authors: LeGrand Karen , Borarin Buntong , Young Glenn M. 
Published: May 2020

AbstractCambodian foods are increasingly consumed outside Southeast Asia, yet are the subject of remarkably few reports. The Khmer culture and culinary traditions of Cambodian people, both historical and contemporary, depend most heavily on the fermented fish product prohok ("Image missing") as an essential ingredient in a wide variety of dishes. The aim of this report is to better understand the traditions, production methods, and uses of prohok as well as the retention of this essential flavoring and nutritional component of Khmer cuisine. The reported findings include how fish preservation developed to accommodate Cambodia's unique naturally occurring hydrological phenomena and has influenced the ethnic identity and social structure of Khmer people. Commercial and home production of prohok is observed to have socioeconomic and nutritional impact on people. The uses of prohok in main dishes, sauces, soups, and side dishes are explored. Furthermore, this report investigates and reviews the underlying microbiology and chemistry that takes place during traditional fermentations of fish to produce prohok. This foundational knowledge serves as a basis for additional scientific studies to further investigate prohok fermentations with the goal to better understand factors that contribute to the unique regional variation of aromas, textures, and flavors produced by traditional practitioners and beloved by Khmer people.
Affective lability across psychosis spectrum disorders
Authors: Høegh Margrethe Collier , Melle Ingrid , Aminoff Sofie R. , Laskemoen Jannicke Fjæra , Büchmann Camilla Bakkalia , Ueland Torill , Lagerberg Trine Vik 
Published: May 2020

Abstract

Background.
Despite apparent clinical remission, individuals with psychotic disorders often experience significant impairments across functional domains. Thus, there is a need to search beyond management of core symptoms to optimize treatment outcomes. Affective dysregulation is considered a risk factor for poor clinical and functional outcomes in many mental disorders, but research investigating such features in psychosis, particularly in schizophrenia, is limited. We aimed to investigate the level of affective lability (AL) in participants with schizophrenia- and bipolar spectrum disorders (n = 222) compared to healthy controls (n = 140), as well as clinical correlates of AL in the diagnostic groups.

Methods.
The Affective Lability Scale (ALS-SF) was used to measure total score of AL and subscores covering the domains of anxiety/depression, depression/elation, and anger. An analysis of covariance was performed to compare the ALS-SF total score between groups, correcting for potential confounders, as well as standard multiple regression analyses for diagnosis-specific investigations of the relationship between AL and demographic and clinical features.

Results.
Both the schizophrenia- and bipolar spectrum group had significantly higher ALS-SF total score compared to controls (p < 0.001), and no significant differences between the patient groups were found. In the schizophrenia group, current psychotic and depressive symptoms were significantly and independently associated with AL (p = 0.012 and p = 0.024, respectively).

Conclusions.
The findings indicate that AL is elevated in psychotic disorders and that it transcends diagnostic boundaries. Further research into the causal relationship between psychotic and affective symptoms and AL, as well as its role as a potential therapeutic target in psychosis spectrum disorders, is warranted.
On the Trail of the Sibyl’s Mountain
Authors: Griffin Miranda 
Published: May 2020

Abstract
This essay focuses on the recurrent metaphor of a painstaking journey in Bruno Latour’s An Inquiry into Modes of Existence and the ways in which it can be deployed as a reading of the world. I use this metaphor to scrutinize the transmission, in manuscript Chantilly, Musée Condé 653, of Antoine de la Sale’s Le Paradis de la Reine Sibylle, a fifteenth-century account of travel to, and myths associated with, the Monte della Sibilla in the Apennine Mountains of Italy. From a Latourian perspective, Chantilly 653 attests to the agency of a mountainous landscape and the myths that inhabit it, as well as to the ways in which myths solicit representation in material form. In this instance, material form is a medieval manuscript, one that can be read, through a Latourian lens, as a set of category crossings that bring together points in space and time. Those points are not organized as historical periods but rather as modes of understanding the world.
Fugitive Figures
Authors: Franklin-Brown Mary 
Published: May 2020

Abstract
Through a study of early French romances, especially the Conte de Floire et Blancheflor and Alexandre de Paris’s Roman d’Alexandre, this essay offers a new approach to the automaton in medieval literature. Bruno Latour’s plural ontology, which elaborates on the earlier work of Gilbert Simondon and Étienne Souriau, provides a way to break down the division between the human mind and the world (and hence the mind and the machine), offering a rich understanding of the way in which the beings of technology [TEC], fiction [FIC], and religion [REL] act in concert upon us to inspire our desire for technological fictions.
Visualizing Elemental Ontology in theLivre des propriétés des choses
Authors: Sunderland Luke 
Published: May 2020

AbstractThis essay offers an encounter with Bruno Latour’s account of ontological pluralism by way of a close reading of the Livre des propriétés des choses, Jean Corbechon’s fourteenth-century French translation of Bartholomaeus Anglicus’s encyclopedia. Engagement with Latour’s Inquiry into Modes of Existence enables a new reading of medieval encyclopedias that takes seriously Latour’s suggestion that premodern cosmologies retain importance for modern ecological thought while simultaneously challenging his arguments about the rigidity of ontologies based on ideas of nature, substance, and matter. This essay argues that the Livre deploys precisely such an ontology in dynamic and flexible ways. The varying visual programs in Livre manuscripts each configure the encyclopedia’s ontology differently, either making humans privileged observers of nature or positioning them as subject to its laws while adopting varying solutions for communicating ontological contentions to readers.
Improving Hand Hygiene Adherence in Healthcare Workers Before Patient Contact: A Multimodal Intervention in Four Tertiary Care Hospitals in Japan
Authors: Saitoh Akihiko , Sato Kiyomi , Magara Yoko , Osaki Kakuei , Narita Kiyoko , Shioiri Kumiko , Fowler Karen E , Ratz David , Saint Sanjay 
Published: May 2020

BACKGROUNDHand hygiene is key to preventing healthcare‐associated infection and the spread of respiratory viruses like the novel coronavirus that causes COVID‐19. Unfortunately, hand hygiene adherence of healthcare workers (HCWs) in Japan is suboptimal according to previous studies.OBJECTIVESOur objectives were to evaluate hand hygiene adherence among physicians and nurses before touching hospitalized patients and to evaluate changes in hand hygiene adherence after a multimodal intervention was implemented.DESIGN, SETTING, AND PARTICIPANTSWe conducted a pre‐ and postintervention study with HCWs at four tertiary hospitals in Niigata, Japan. Hand hygiene observations were conducted from June to August 2018 (preintervention) and February to March 2019 (postintervention).INTERVENTIONThe multimodal hand hygiene intervention recommended by the World Health Organization was tailored to each hospital and implemented from September 2018 to February 2019.MAIN OUTCOMES AND MEASURESWe observed hand hygiene adherence before touching patients in each hospital and compared rates before and after intervention. Intervention components were also evaluated.RESULTSThere were 2,018 patient observations preintervention and 1,630 postintervention. Overall, hand hygiene adherence improved from 453 of 2,018 preintervention observations (22.4%) to 548 of 1,630 postintervention observations (33.6%; P < .001). Rates improved more among nurses (13.9 percentage points) than among doctors (5.7 percentage points). Improvement varied among the hospitals: Hospital B (18.4 percentage points) was highest, followed by Hospitals D (11.4 percentage points), C (11.3 percentage points), and Hospital A (6.5 percentage points).CONCLUSIONSA multimodal intervention improved hand hygiene adherence rates in physicians and nurses in Niigata, Japan; however, further improvement is necessary. Given the current suboptimal hand hygiene adherence rates in Japanese hospitals, the spread of COVID‐19 within the hospital setting is a concern.
Aging Population, Retirement, and Risk Taking: Reply
Authors: Levy Haim 
Published: May 2020

In theorem 1 given in my paper, “Aging Population, Retirement, and Risk Taking” [Levy H (2016a) Aging population, retirement, and risk taking. Management Sci. 62(5):1415–1430.], there is indeed a technical error. Yet, adding one condition to the theorem (which can be added in two alternate ways) is sufficient to ensure the dominance of stocks over bonds in the very long run. For the commonly employed preferences, the empirical evidence conforms with the claim given in my original theorem 1, asserting that the portfolio with the higher geometric mean (stocks) dominates the other portfolio under consideration (bonds) as the investment horizon increases indefinitely. Thus, as advocated in my paper, stocks dominate bonds for investors with typical preferences who save for retirement. This paper was accepted by Karl Deither, finance.
From the frontier to the border
Authors: Coughlin Richard W. 
Published: May 2020

Review of: Empire of Borders: The Expansion of the U.S. Border Around the World, Todd Miller (2019)
London: Verso
ISBN 978-1-78478-511-6, h/bk, $22.49

The End of the Myth: From the Frontier to the Border Wall in the Mind of America, Greg Grandin (2019)
New York: Metropolitan Books
ISBN 978-1-25017-982-1, h/bk, $30.00
Pengaruh intervensi pendidikan gizi terhadap peningkatan pengetahuan gizi, perubahan asupan zat gizi dan indeks massa tubuh remaja kelebihan berat badan
Authors: Nurmasyita Nurmasyita , Widjanarko Bagoes , Margawati Ani 
Published: May 2020

Background: Adolescence overweight due to excessive intake and physical inactivity. This situation will continue until adulthood and cause degenerative diseases. The prevalence of overweight adolescents in senior high school Pontianak is 16,8% (higher than prevalence of obese adolescents in Indonesia).Objective: Analyze impact of nutrition education intervention to increase nutritional knowledge, change nutrient intake and Body Mass Index (BMI) among adolescent overweight in Pontianak high school.Methods: Quasi-experimental study design with control group pre-post test design. Nutrition education intervention to treatment group was gave once a week for 3 months and control group was gave only one for 3 months study. The subject are 73 overweight high school students, taken by purposive sampling and divided into 2 groups: 36 treatment group and 37 control group. Statistical analysis using paired t-test, Wilcoxon test, Independent t-test, Mann-Whitney Test and covariance.Results: This result shows that nutrition education intervention increase nutrition knowledge score (9.58±11.82) and fiber intake (1.05±5.29 g) in treatment group; reduce energy sufficiency rate in treatment and control group (12.42±16.77% and 10.18±0.54%); reduce protein adequacy rate (7.61±12.05%%), carbohydrate intake (3.78±6.71%) and reduce fat intake (3.11±3.96%) in treatment group; reduce BMI in treatment and control group (0.58±0.67 kg/m2 and 0.12±0.34 kg/m2).Conclusion: Nutrition education in overweight adolescent can decrease BMI among them through increase their nutrition knowledge. Nutrition knowledge of overweight adolescent decrease energy adequacy level, protein adequacy level, carbohydrate intake percentage, fat intake percentage, and increase fiber intake.
Pengaruh pemberian ekstrak jamur merang (volvariella volvacea) terhadap kadar kolesterol total, enzim lppla2 dan mda darah
Authors: Damayanty Amelia Eka , Suromo Lisyani B. , Kisdjamiatun RA 
Published: May 2020

Background: Consumption of high-fat diet (HFD) is increasing blood total cholesterol, LpPLA2 enzyme and MDA level which is a cause of atherosclerosis that should be controlled by antioxidants. Paddy straw mushroom (Volvariella v.) extract has an antioxidant compounds. This research proves the effect of Volvariella v. extract on blood total cholesterol (TC), LpPLA2 enzyme and MDA level, and proves correlation between TC with LpPLA2 enzyme and MDA level.Methods: A randomized post test only control group design to twenty four of 8-10 weeks old male Rattus novergicus Wistar strain with 180-200 gram were divided into four group; K1 with standard diet, K2 with HFD, each X1 and X2 with HFD+Volvariella v. extract 500 mg/kg.bwt/day and 1000 mg/kg.bwt/day. All treatments for 56 days. TC levels assesed by enzymatic colorimetric test method, LpPLA2 enzyme with ELISA method and MDA with TBARs method. Data were analyzed by one way Anova, LSD post hoc and Pearson’s correlation.Results: TC mean of K1 (91,28±1,55 mg/dL), K2 (181,96±4,19 mg/dL), X1 (122,94±2,75 mg/dL) and X2 (105,86±2,25 mg/dL); p=0,001. Enzyme LpPLA2 mean of K1 (2,65±3,19 ng/mL), K2 (1,29±1,35 ng/mL), X1 (3,92±2,18 ng/mL), X2 (2,05±3,29 ng/mL); p=0,385 and blood MDA mean of K1 (1,17±0,12 nmol/mL), K2 (5,75±0,21 nmol/mL), X1 (2,96±0,91 nmol/mL) and X2 (1,77±0,92 nmol/mL); p=0,001. Correlation between TC and LpPLA2 enzyme was shown by X1 group (p=0,042; r = - 0,827).Conclusion:Volvariella v. extract decreased blood total cholesterol and MDA level significantly, did not significant to LpPLA2 enzyme. There wss a correlation between TC and LpPLA2 enzyme but was not to TC and blood MDA.
Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma
Authors: Andersen Ulrik Ø , Terzic Dijana , Wewer Albrechtsen Nicolai Jacob , Dall Mark Peter , Plomgaard Peter , Rehfeld Jens F , Gustafsson Finn , Goetze Jens P 
Published: May 2020

Aims
Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in terms of other hormonal axes besides natriuretic peptides. The aim of this study was to examine whether acute inhibition of neprilysin affects meal-induced responses in gastrin and cholecystokinin concentrations in healthy individuals.

Methods and results
Nine healthy young men were included in an open-labelled, randomized cross-over clinical trial. The participants received a standardized meal (25 g fat, 26 g protein, 42 g carbohydrate) on two separate days with or without a one-time dosage of sacubitril ((194 mg)/valsartan (206 mg)). Blood pressure, heart rate and blood samples were measured and collected during the experiment. Statistical differences between groups were assessed using area under the curve together with an ANOVA with a Bonferroni post hoc test. Sacubitril/valsartan increased the postprandial plasma concentrations of both gastrin and cholecystokinin (80% (AUC0-270 min, P = 0.004) and 60% (AUC0-270 min, P = 0.003), respectively) compared with the control meal. No significant hemodynamic effects were noted (blood pressure, AUC0-270 min, P = 0.86, heart rate, AUC0-270 min, P = 0.96).

Conclusion
Our study demonstrates that sacubitril/valsartan increases the postprandial plasma concentrations of gastrin and cholecystokinin in healthy individuals. The results thus suggest that neprilysin-mediated degradation of gastrin and cholecystokinin is physiologically relevant and may have a role in heart failure patients treated with sacubitril/valsartan.
MODY2 in Asia: analysis of GCK mutations and clinical characteristics
Authors: Zhou Yuan , Wang ShengNan , Wu Jing , Dong JianJun , Liao Lin 
Published: May 2020

Aims
Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2. Many patients with MODY2 in Asia have delayed timely treatment because they did not receive the correct diagnosis. This study aims to analyze the clinical characteristics and GCK mutations in Asian MODY2.

Methods
We have collected 110 Asian patients with MODY2 from the PubMed, Embase, Medline, Web of Science, CNKI, and Wanfang with the following search terms: ‘maturity-onset diabetes of the young’ OR ‘MODY’ OR ‘maturity-onset diabetes of the young type 2’ OR ‘MODY2’ OR ‘GCK-DM’ OR ‘GCK-MODY’. Both mutations of GCK and clinical characteristics of MODY2 were analyzed.

Results
There were 96 different mutations that occurred in coding regions and non-coding regions. Exon 5 and 7 were the most common location in coding regions and missense was the primary mutation type. The proportion of probands younger than 25 was 81.8%, and 81.4% of the probands had family history of hyperglycaemia. Ninety percent and 93% of Asian MODY2 probands exhibited mild elevation in FPG (5.4–8.3 mmol/L) and HbA1c (5.6–7.6%), respectively.

Conclusions
In most Asian patients, MODY2 occurred due to GCK mutation in coding regions, and exon 5 and 7 were the most common locations. FPG, HbA1c, and familial diabetes were important reference indicators for diagnosing MODY2. Altogether, the study indicates that for the young onset of diabetes with mild elevated blood glucose and HbA1c and family history of hyperglycaemia, molecular genetic testing is suggested in order to differentiate MODY2 from other types of diabetes earlier.
Biallelic CYP24A1 variants presenting during pregnancy: clinical and biochemical phenotypes
Authors: Griffin Tomás P , Joyce Caroline M , Alkanderi Sumaya , Blake Liam M , O’Keeffe Derek T , Bogdanet Delia , Islam Md Nahidul , Dennedy Michael C , Gillan John E , Morrison John J , O’Brien Timothy , Sayer John A , Bell Marcia , O’Shea Paula M 
Published: May 2020

Introduction
Inactivating mutations in CYP24A1, encoding vitamin D-24-hydroxylase, can lead to an accumulation of active vitamin D metabolites and consequent hypercalcaemia. Patient (infantile and adult) presentation is varied and includes mild-severe hypercalcaemia, hypercalciuria, nephrocalcinosis and nephrolithiasis. This study aimed to characterize the clinical and biochemical phenotypes of a family with two CYP24A1 missense variants.

Methods
The proband and seven family members underwent detailed clinical and biochemical evaluation. Laboratory measurements included serum calcium, intact parathyroid hormone (iPTH), vitamin D metabolites and urine calcium and creatinine.

Results
The proband presented during the second trimester of a planned pregnancy with flu-like symptoms. Laboratory tests showed elevated adjusted calcium of 3.27 (upper reference limit (URL: 2.30) mmol/L), suppressed iPTH (<6 ng/L), elevated 25(OH)D (264 (URL: 55) nmol/L) and elevated 1,25(OH)D (293 (URL: <280) pmol/L). Ionized calcium was 1.55 (URL: 1.28) mmol/L. Sanger sequencing revealed two heterozygous missense variants in the CYP24A1: p.(Arg439Cys), R439C and p.(Trp275Arg), W275R. The proband’s brother and sister had the same genotype. The brother had intermittent hypercalcaemia and hypervitaminosis D. Only the sister had a history of nephrolithiasis. The proband’s daughter and two nephews were heterozygous for the R439C variant. The proband and her brother frequently had elevated 25(OH)D:24,25(OH)2D ratios (>50) during follow-up.

Conclusions
W275R is a new pathogenic CYP24A1 mutation in compound heterozygotic form with R439C in this family.
Dinámica de nitrógeno del suelo en agroecosistemas bajo el efecto de abonos verdes
Authors: Sosa Rodrigues Breno Augusto , Sanchez de Prager Marina , García Yuly , Espinoza Marden , Rodriguez Jesus , Sosa Glauco 
Published: May 2020

Los abonos verdes (AV) son frecuentemente utilizados en agroecosistemas para mejorar y/o restaurar la fertilidad del suelo. El objetivo de este estudio fue evaluar la dinámica de nitrógeno (N) y carbono (C) del suelo en sistemas de maíz y soya bajo el efecto de AV residuales. En un Vertisol Typic Haplustert ubicado en el Valle del Cauca-Colombia se estableció la asociación Mucuna pruriens var. utilis – maíz (Zea mays), la cual 90 días después de la siembra fue incorporada al suelo como AV o se dispuso sobre la superficie del suelo como acolchado orgánico (AO). Posteriormente fueron sembrados los cultivos maíz-soya en forma intercalada para formar 11 tratamientos bajo el diseño de bloques completos al azar con arreglo factorial 32 +2 y tres repeticiones. Las parcelas principales fueron AV, AO y barbecho (B). Las subparcelas correspondieron a la fertilización con compost, fertilizante de síntesis química industrial y cero fertilizaciones (testigo). En forma paralela fueron sembrados como referentes los monocultivos de maíz y soya manejados de forma tradicional. En las etapas de floración y llenado de grano de los cultivos se midieron como variables en suelo: N total, amonio, nitrato, N-inorgánico total, carbono orgánico; y en tejido vegetal de maíz y soya: carbono y N. Los resultados mostraron que, la aplicación de materiales orgánicos de alta calidad, AV/AO, estimularon la mineralización del C y la dinámica de las diferentes fracciones de N en el suelo, sin cambios significativos en el contenido de estos elementos en el tejido vegetal del cultivo de maíz y soya.
Influence of high planting densities and arrangements on yield and fruit development of Musa AAA Simmonds
Authors: Barrera Violet José Luis , Cartagena Jose Regulo , Nanclares Gómez Omar Alonso 
Published: May 2020

Banana is one of the most abundantly consumed fruits in the world for its contribution to human nutrition, including an important content of potassium. Given the social contribution of this crop in the cropping areas of Colombia, it is necessary to develop agronomic management strategies that contribute to increasing productivity and offering alternatives that regulate the effects of climate seasonality on banana production in the Urabá region of Colombia. For this purpose, different planting densities (2,000, 2,500, 3,000 and 3,500 plants ha-1) and planting arrangements (triangle, rectangle and double furrow), plus a relative control (1,700 plants ha-1 under triangle arrangement), were evaluated in the banana cv. Williams. The experimental design corresponded to randomized complete blocks in a 4 x 3 + 1 (densities x arrangements + control treatment at 1,700 plants ha-1) factorial arrangement. During harvest, the following parameters were monitored: bunch weight, number of hands and fingers per bunch, finger length and diameter, bunch ratio and percentage of loss per bunch. Two analyses of variance were carried out, a general one including the control treatment, and an additional one excluding it. The double furrow planting arrangement favored the productivity of the crop in terms of a greater assimilation and lesser loss records at the bunch level. The strong correlation of the studied variables with the double furrow arrangement became evident.