bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of patients undergoing hemodialysis with COVID‐19
Authors: Tian Ming , Li Hua , Yan Ting , Dai Yujie , Dong Liping , Wei Honglan , Song Xiaohong , Dong Junwu , Cheng Fangxiong , Li Wenzhou 
Published: October 2020

AbstractHemodialysis patients are susceptible to coronavirus disease 2019 (COVID‐19). The aim of this study was to describe the epidemiological, clinical characteristics, and mortality‐related risk factors for those who undergoing hemodialysis with COVID‐19. We conducted a retrospective study. A total of 49 hemodialysis patients with COVID‐19 (Group 1) and 74 uninfected patients (Group 2) were included. For patients in Group 1, we found the median age was 62 years (36‐89 years), 59.3% were male, and the median dialysis vintage was 26 months. Twenty‐eight patients (57%) had three or more comorbidities and two patients (4%) died. The most common symptoms were fever (32.7%) and dry cough (46.9%), while nine patients (18.4%) were asymptomatic. Blood routine tests indicated lymphocytopenia, the proportion of lymphocyte subsets was generally reduced, and chest CT scans showed ground‐glass opacity (45.8%) and patchy shadowing (35.4%). However, these findings were not specific to hemodialysis patients with COVID‐19, and similar manifestations could be found in patients without SARS‐CoV‐2 infection. In conclusion, for hemodialysis patients with COVID‐19, lymphocytopenia and ground‐glass opacities or patchy opacities were common but not specific to them, early active treatment and interventions against nosocomial infection can significantly reduce the mortality and the risk of SARS‐CoV‐2 infection.
Infectious complications after allogeneic hematopoietic stem cell transplantation in children in a bone marrow transplant unit in Colombia
Authors: Bravo Ana Milena , Arango Jailer , Ramirez Oscar , Portilla Carlos Andres , López Pio , Calle Juan Pablo , López‐Medina Eduardo 
Published: October 2020

AbstractObjectiveThere is a relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo‐HSCT) in developing countries. Herein, we describe the incidence rates of different infections according to the transplant period and baseline condition in Colombia.MethodsIn a retrospective cohort study of all children who underwent allo‐HSCTs from 2012 to 2017 in a hospital in Cali, Colombia, we reviewed medical records from the first post‐transplant day until day + 365 to describe microbiologically confirmed incidence rates of infections and deaths during three post‐transplant periods and according to baseline condition.ResultsMost allo‐HSCT (n = 144, 96%) were followed by infections over the following year, mostly due to bacteria and cytomegalovirus (4.3 and 3.3 per 1000 patient‐days, respectively). Children were at the highest risk for infection in the first 30 days post‐HSTC, but mortality was highest after 100 days. Overall, high mortality (n = 44, 31.7%) was associated with infections, especially from extensively drug‐resistant bacteria, adenovirus, and aspergillosis. Infection rates were similar independent of the baseline condition.ConclusionAlmost all children in this cohort developed infections post allo‐HSCT. Describing the distribution of infections throughout the first post allo‐HSCT year allows clinicians to narrow the differential diagnosis of infections according to the post‐transplant period. This is especially useful when prioritizing interventions in children receiving HSCT in stringent healthcare systems in developing countries.
Expression dynamics of dehydration tolerance in the tropical plantMarchantia inflexa
Authors: Marks Rose A. , Smith Jeramiah J. , VanBuren Robert , McLetchie David Nicholas 
Published: October 2020

SummaryTolerance to prolonged water deficit occurs along a continuum in plants, with dehydration tolerance (DhT) and desiccation tolerance (DT) representing some of the most extreme adaptations to water scarcity. Although DhT and DT presumably vary among individuals of a single species, this variability remains largely unstudied. Here, we characterized expression dynamics throughout a dehydration−rehydration time‐course in six diverse genotypes of the dioecious liverwort Marchantiainflexa. We identified classical signatures of stress response inM.inflexa, including major changes in transcripts related to metabolism, expression of LEA and ELIP genes, and evidence of cell wall remodeling. However, we detected very little temporal synchronization of these responses across different genotypes ofM.inflexa, which may be related to genotypic variation among samples, constitutive expression of dehydration‐associated transcripts, the sequestration of mRNAs in ribonucleoprotein partials prior to drying, or the lower tolerance ofM.inflexarelative to most bryophytes studied to date. Our characterization of intraspecific variation in expression dynamics suggests that differences in the timing of transcriptional adjustments contribute to variation among genotypes, and that developmental differences impact the relative tolerance of meristematic and differentiated tissues. This work highlights the complexity and variability of water stress tolerance, and underscores the need for comparative studies that seek to characterize variation in DT and DhT.
Membrane lipid remodeling is required for photosystem II function under low CO2
Authors: Jimbo Haruhiko , Izuhara Taichi , Hirashima Takashi , Endo Kaichiro , Nakamura Yuki , Wada Hajime 
Published: October 2020

SummaryMembrane lipid remodeling in plants and microalgae has a crucial role in their survival under nutrient‐deficient conditions. Aquatic microalgae have low access to CO2, an essential carbon source for photosynthetic assimilates; however, 70–90 mol% of their membrane lipids are sugar‐derived lipids (glycolipids) such as monogalactosyldiacylglycerol (MGDG). In this study, we discovered a new system of membrane lipid remodeling responding to CO2 in Synechocystis sp. PCC 6803, a unicellular, freshwater cyanobacterium. As compared with higher CO2 (HC; 1% CO2), under ambient air (lower CO2: LC), phosphatidylglycerol (PG) content was increased at the expense of MGDG content. To explore the biological significance of this alteration in content, we generated a transformant of Synechocystis sp. PCC 6803 overexpressing sll0545 gene encoding a putative phosphatidic acid phosphate (oxPAP), which produces diacylglycerol that is used for the synthesis of glycolipids, and examined the effect on membrane lipid remodeling and phototrophic growth responding to LC. Photosystem II (PSII) activity and growth rate were inhibited under LC in oxPAP cells. PG content was substantially reduced, and MGDG and sulfoquinovosyldiacylglycerol contents were increased in oxPAP cells as compared with control cells. These phenotypes in oxPAP cells were recovered under the HC condition or PG supplementation. Increased PG content may be required for proper functioning of PSII under LC conditions.
Retrospective evaluation of albuterol inhalant exposure in dogs: 36 cases (2007–2017)
Authors: Meroni Emiliana R. , Khorzad Roxanna , Bracker Kiko , Sinnott‐Stutzman Virginia 
Published: October 2020

AbstractObjectiveTo describe the clinical features, clinicopathological features, treatment, and outcome of dogs presented for albuterol exposure.DesignRetrospective case series from January 2007 to December 2017.SettingTertiary veterinary facility.AnimalsThirty‐six client‐owned dogs presenting for known or suspected albuterol exposure secondary to chewing on albuterol metered‐dose inhalers (MDIs).InterventionsNone.Measurements and main resultsAll dogs presented with clinical signs attributable to albuterol exposure. The most common physical examination abnormality was sinus tachycardia, noted in 34 of 36 (94%) dogs. Twenty‐seven patients (75%) were admitted to the hospital for therapy, with a median length of hospitalization of 20.5 hours (16.75–24.5). Thirty‐two of 36 dogs had serum electrolytes evaluated at admission, with 22 of 32 (69%) presenting with hypokalemia ([K+] < 3.62 mmol/L]). Hyperlactatemia ([lactate] > 2.80 mmol/L) was noted in 23 of 28 (82%) dogs. A negative correlation was found between serum lactate and potassium (r = –0.64, r2 = 0.40, P = 0.0003). Hyperglycemia ([glucose] > 6.44 mmol/L) was noted in 20 of 30 (67%) dogs. Beta antagonist therapy was utilized in 20 of 36 (56%) of dogs.ConclusionsAlthough uncommon, albuterol intoxication can lead to significant clinical and electrolyte abnormalities. Albuterol‐induced hypokalemia and associated tachyarrhythmias can be successfully managed, and albuterol intoxication has an excellent prognosis for survival to discharge. A minimum database should be evaluated in all dogs presenting for suspected albuterol exposure, with lactate and glucose monitored carefully in dogs with moderate or severe hypokalemia given the correlation found.
Evidence supporting wound care end points relevant to clinical practice and patients' lives. Part 3: The Patient Survey
Authors: Gould Lisa J. , Liu Jing , Wan Rou , Carter Marissa J. , Dotson Margaret (Peggy) , Driver Vickie R 
Published: October 2020

AbstractThe 2006 U.S. Food and Drug Administration Guidance for Industry emphasizes wound closure as the primary outcome for clinical trials in wound healing. Wound care professionals understand that complete wound healing is not always achievable when evaluating new treatments. FDA, Association for the Advancement of Wound Care, and Wound Healing Society are working collaboratively to identify scientifically achievable, clinically relevant, and patient‐centered endpoints with sufficient support to serve as primary outcomes for clinical trials. The Opinion Survey from People with Wounds presented here addresses an important but understudied issue: the gap between clinician, healthcare insurance companies, government agencies, and patient perspectives regarding clinically meaningful and scientifically achievable primary endpoints for wound care. The survey, adapted from the clinician survey with adjustment for health literacy, was pilot tested and revised based on a limited number of patients in a single clinic. After central IRB approval, the on‐line survey was administered in English and Spanish and submitted anonymously to a server with the cooperation of multiple wound clinics and societies. Four hundred and thirty‐eight patients and caregivers from across the United States responded over a 10‐month period. Based on this survey, the most valuable clinical endpoints were reduced infection, recurrence, and amputation. The most valuable quality of life outcomes were increased independence, reduced social isolation, and pain. The top five endpoints in terms of usefulness for measuring clinical trial success were time to heal, wound size, infection, recurrence, and pain. Narrative responses from wound patients emphasized the inability to perform activities of daily living and pain as major factors that impacted their daily lives. Engagement of patients in clinical trials and evaluation of potential treatments is critical to improving wound care. This survey provides insight into the needs of patients with wounds and provides a roadmap for structuring future clinical trials to better meet those needs.
Analytical and Experimental Evaluation of Various Active Suspension Alternatives for Superior Ride Comfort and Utilization of Autonomous Vehicles
Authors: Cvok Ivan , Hrgetić Mario , Hoić Matija , Deur Joško , Hrovat Davor , Eric Tseng H. 
Published: October 2020

Abstract
Autonomous vehicles (AVs) give the driver opportunity to engage in productive or pleasure-related activities, which will increase AV’s utility and value. It is anticipated that many AVs will be equipped with active suspension extended with road disturbance preview capability to provide the necessary superior ride comfort resulting in almost steady work or play platform. This article deals with assessing the benefits of introducing various active suspensions and related linear quadratic regulator (LQR) controls in terms of improving the work/leisure ability. The study relies on high-performance shaker rig-based tests of a group of 44 drivers involved in reading/writing, drawing, and subjective ride comfort rating tasks. The test results indicate that there is a threshold of root-mean-square vertical acceleration, below which the task execution performance is similar to that corresponding to standstill conditions. For the given, relatively harsh road disturbance profile, only the fully active suspension with road preview control can suppress the vertical acceleration below the above critical superior comfort threshold. However, when adding an active seat suspension, the range of chassis suspension types for superior ride comfort is substantially extended and can include semi-active suspension and even passive suspension in some extreme cases that can, however, lead to excessive relative motion between the seat and the vehicle floor. The design requirements gained through simulation analysis, and extended with cost and packaging requirements related to passenger car applications, have guided design of two active seat suspension concepts applicable to the shaker rig and production vehicles.
Swirling Flame Combustion of Heavy Fuel Oil: Effect of Fuel Sulfur Content
Authors: Pei Xinyan , Abdul Jameel Abdul Gani , Chen Chaoqin , AlGhamdi Ibrahim A. , AlAhmadi Kamal , AlBarakati Eid , Saxena Saumitra , Roberts William L. 
Published: October 2020

Abstract
In the present work, an experimental investigation on the effect of sulfur content in heavy fuel oil (HFO) on the gaseous emissions under swirling flame conditions was carried out. The sulfur content in HFO was varied by blending with ultra-low sulfur diesel and four fuel samples containing 3.15, 2.80, 1.97, and 0.52% sulfur (by mass) were prepared. Pure asphaltenes were added to the blends to ensure that the asphaltene content in the fuel remained the same. The fuels were then fired in a high-swirl stabilized, turbulent spray flame. The combustion performance of the fuels was evaluated by measuring flame temperature distribution, gaseous emissions (SOx, NOx, CO, CO2, and flue gas pH), and particulate matter (PM) emissions (morphology, composition, and pH). The results showed a significant reduction in the SO2 emissions and acidity of the flue gas when the sulfur content in the fuel was reduced, as expected. The reduction was more than would be expected based on sulfur content, however. For example, the flue gas SO2 concentration reduced from 620 ppm to 48 ppm when the sulfur content in the fuel was reduced from 3.15 to 0.52% (by mass). Sulfur balance calculations indicate that nearly 97.5% of the sulfur in the fuel translates into gaseous emissions and the remaining 2.5% appears in PM emissions. Ninety-five percent of the gaseous sulfur emissions are SO2, whereas the rest appears as SO3. Varying the sulfur content in the fuel did not have a major impact on the flame temperature distribution or NOx emissions. The morphologies and the size distribution of the PM also did not change significantly with the sulfur content as the asphaltenes content of the fuels remained the same.
Co-Simulation: Error Estimation and Macro-Step Size Control
Authors: Meyer T. , Kraft J. , Schweizer B. 
Published: October 2020

Abstract
Efficiency and accuracy of a co-simulation may considerably be increased by using a variable communication-time grid. Therefore, an error estimator for controlling the macro-step size is required. Here, error estimators are derived and investigated for explicit and implicit co-simulation approaches. The paper focuses on mechanical co-simulation models. The basic results may, however, also be applied to arbitrary, non-mechanical co-simulation models.
Heat Transfer in Composite Spheroids
Authors: Alassar Rajai 
Published: October 2020

AbstractHeat transfer from a composite prolate spheroid under the third-type boundary condition is investigated using a Legendre series expansion. The model is verified against published data on cooling boiled eggs and also against the asymptotic solution of a composite sphere. The impact of Biot number on the heat transfer in spheroids with realistic dimensions and properties, such as eggs and olives, is investigated. The results are also presented for varying conductivity ratios and fractional volume of the inner part of the spheroid.
On the Steady-State Workpiece Flow Mechanism and Force Prediction Considering Piled-Up Effect and Dead Metal Zone Formation
Authors: Hu Cheng , Zhang Weiwei , Zhuang Kejia , Zhou Jinming , Ding Han 
Published: October 2020

Abstract
The manufacturing of miniaturized components is indispensable in modern industries, where the uncut chip thickness (UCT) inevitably falls into a comparable magnitude with the tool edge radius. Under such circumstances, the ploughing phenomenon between workpiece and tool becomes predominant, followed by the notable formation of dead metal zone (DMZ) and piled-up chip. Although extensive models have been developed, the critical material flow status in such microscale is still confusing and controversial. In this study, a novel material separation model is proposed for the demonstration of workpiece flow mechanism around the tool edge radius. First, four critical positions of workpiece material separation are determined, including three points characterizing the DMZ pattern and one inside considered as stagnation point. The normal and shear stresses as well as friction factors along the entire contact region are clarified based on slip-line theory. It is found that the friction coefficient varies symmetrically about the stagnation point inside DMZ and remains constant for the rest. Then, an analytical force prediction model is developed with Johnson–Cook constitutive model, involving calibrated functions of chip-tool contact length and cutting temperature. The assumed tribology condition and morphologies of material separation including DMZ are clearly observed and verified through various finite element (FE) simulations. Finally, comparisons of cutting forces from cutting experiments and predicted results are adopted for the validation of the predictive model.
Analytical and Numerical Prediction of Springback of SS/Al-Alloy Cladded Sheet in V-Bending
Authors: Sharma Pankaj Kumar , Gautam Vijay , Agrawal Atul Kumar 
Published: October 2020

Abstract
The present work deals with the development of an analytical model incorporating the effects of anisotropy and strain hardening to predict the springback in V-bending of two-ply sheet metal using a punch profile radius of 15 mm and included a bend angle of 90 deg. In the analytical model, the total bending moment is determined from resulting bending stresses for two different layers arranged in parallel planes one above the other and a new radius of curvature after springback is determined by applying a negative bending moment. The two-ply sheet composed of layers of AA1050 and SS430 is characterized for its tensile properties to be used in analytical and numerical models for prediction of springback. To study the effect of each layer during bending operation, two possible cases of sheet placements during bending and springback are studied; i.e., in the first case, the inner layer is of AA1050 while the SS430 layer is the outer layer whereas in the second case it is opposite. In all the cases of springback experiments when the outer layer is of SS430, the springback values are higher than the values obtained with the specimens when the inner layer is of SS430. This could be attributed to the higher tensile strength of the stainless steel layer and the higher bending radius experienced by it. The springback behaviors are also analyzed by simulations using Hill's anisotropic yield criterion in abaqus software. The springback results obtained by simulations and analytical models are in good agreement in general; however, in some cases, discrepancy of more than 15% is observed in the analytical results when compared with the experimental results.
Reliability Analysis and Random Vibration of Nonlinear Systems Using the Adjoint Method and Projected Differentiation
Authors: Papadimitriou Dimitrios , Mourelatos Zissimos P. , Hu Zhen 
Published: October 2020

Abstract
This paper proposes a new methodology for time-dependent reliability and random vibrations of nonlinear vibratory systems using a combination of a time-dependent adjoint variable (AV) method and a projected differentiation (PD) method. The proposed approach is called AV-PD. The vibratory system is excited by stationary Gaussian or non-Gaussian input random processes. A Karhunen–Loeve (KL) expansion expresses each input random process in terms of standard normal random variables. The nonlinear equations of motion (EOM) are linearized using a Taylor expansion using the first-order derivatives of the output with respect to the input KL random variables. An adjoint approach obtains the output derivatives accurately and efficiently requiring the solution of as many sets of EOM as the number of outputs of interest, independently of the number of KL random variables. The proposed PD method then computes the autocorrelation function of each output process at an additional cost of solving as many sets of EOM as the number of outputs of interest, independently of the time horizon (simulation time). A time-dependent reliability analysis is finally performed using a KL expansion of the output processes and Monte Carlo simulation (MCS). The number of solutions of the EOM scales only with the number of output random processes which is commonly much smaller than the number of input KL random variables. The efficiency and accuracy of the proposed approach is demonstrated using a four degree-of-freedom (DOF) half-car vibratory problem.
A Dynamically Balanced Kinematically Redundant Planar Parallel Robot
Authors: Baron Nicholas , Philippides Andrew , Rojas Nicolas 
Published: October 2020

AbstractA dynamically balanced robotic manipulator does not exert forces or moments onto the base on which it is fixed; this can be important for the performance of parallel robots as they are able to move at very high speeds, albeit usually have a reduced workspace. In recent years, kinematically redundant architectures have been proposed to mitigate the workspace limitations of parallel manipulators and increase their rotational capabilities; however, dynamically balanced versions of these architectures have not yet been presented. In this paper, a dynamically balanced kinematically redundant planar parallel architecture is introduced. The manipulator is composed of parallelogram linkages that reduce the number of counter rotary elements required to moment balance the mechanism. The balancing conditions are derived, and the balancing parameters are optimized using Lagrange multipliers, such that the total mass and inertia of the system is minimized. The elimination of the shaking forces and moments is then verified via a simulation in the multi-body dynamic simulation software msc adams.