bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA ANRIL enhances mitochondrial function of hepatocellular carcinoma by regulating the MiR‐199a‐5p/ARL2 axis
Authors: Li Kun , Zhao Bao , Wei Diandian , Cui Yixuan , Qian Lisheng , Wang Wenrui , Liu Guodong 
Published: October 2019

AbstractAlthough the roles of long non‐coding RNA (lncRNA) ANRIL (Antisense non‐coding RNA in the INK4A locus) have been established in various tumors, its roles in mitochondrial metabolic reprogramming of hepatocellular carcinoma (HCC) cells are still unclear. This work aims to explore lncRNA ANRIL roles in regulating the mitochondrial metabolic reprogramming of liver cancer cells. First, we found that lncRAN ANRIL expression was significantly increased in HCC tissues or cells compared with the normal adjacent tissues and normal tissues or cells. Functional experiment showed that overexpression of lncRNA ANRIL promoted mitochondrial function in HCC cells, evident by the increased mitochondrial DNA copy numbers, ATP (Adenosine triphosphate) level, mitochondrial membrane potential, and the expression levels of mitochondrial markers, while ANRIL knockdown exerted the opposite effects. Mechanistically, lncRNA ANRIL acted as a competing endogenous RNA to increase ARL2 (ADP‐ribosylationfactor‐like 2) expression via sponging miR‐199a‐5p. Notably, the miR‐199a‐5p/ARL2 axis is necessary for ANRIL‐mediated promoting effects on HCC cell mitochondrial function. This work reveals a novel ANRIL‐miR‐199a‐5p‐ARL2 axis in HCC cell progression, which might provide potential targets for HCC treatment.
Healthcare providers’ perspectives of disrespect and abuse in maternity care facilities in Nigeria: a qualitative study
Authors: Orpin Joy , Puthussery Shuby , Burden Barbara 
Published: October 2019

Abstract

Objectives
To explore healthcare providers’ perspectives of disrespect and abuse in maternity care and the impact on women’s health and well-being.

Methods
Qualitative interpretive approach using in-depth semi-structured interviews with sixteen healthcare providers in two public health facilities in Nigeria. Interviews were audio-recorded, transcribed, and analysed thematically.

Results
Healthcare providers’ accounts revealed awareness of what respectful maternity care encompassed in accordance with the existing guidelines. They considered disrespectful and abusive practices perpetrated or witnessed as violation of human rights, while highlighting women’s expectations of care as the basis for subjectivity of experiences. They perceived some practices as well-intended to ensure safety of mother and baby. Views reflected underlying gender-related notions and societal perceptions of women being considered weaker than men. There was recognition about adverse effects of disrespect and abuse including its impact on women, babies, and providers’ job satisfaction.

Conclusions
Healthcare providers need training on how to incorporate elements of respectful maternity care into practice including skills for rapport building and counselling. Women and family members should be educated about right to respectful care empowering them to report disrespectful practices.
Sparse force-bearing bridges between neighboring synaptic vesicles
Authors: Wesseling John F. , Phan Sébastien , Bushong Eric A. , Siksou Léa , Marty Serge , Pérez-Otaño Isabel , Ellisman Mark 
Published: October 2019

Abstract
Most vesicles in the interior of synaptic terminals are clustered in clouds close to active zone regions of the plasma membrane where exocytosis occurs. Electron-dense structures, termed bridges, have been reported between a small minority of pairs of neighboring vesicles within the clouds. Synapsin proteins have been implicated previously, but the existence of the bridges as stable structures in vivo has been questioned. Here we use electron tomography to show that the bridges are present but less frequent in synapsin knockouts compared to wildtype. An analysis of distances between neighbors in wildtype tomograms indicated that the bridges are strong enough to resist centrifugal forces likely induced by fixation with aldehydes. The results confirm that the bridges are stable structures and that synapsin proteins are involved in formation or stabilization.
Coloring Intersection Hypergraphs of Pseudo-Disks
Authors: Keszegh Balázs 
Published: October 2019

Abstract
We prove that the intersection hypergraph of a family of n pseudo-disks with respect to another family of pseudo-disks admits a proper coloring with four colors and a conflict-free coloring with $$O(\log n)$$

O
(
log
n
)

colors. Along the way we prove that the respective Delaunay-graph is planar. We also prove that the intersection hypergraph of a family of n regions with linear union complexity with respect to a family of pseudo-disks admits a proper coloring with constantly many colors and a conflict-free coloring with $$O(\log n)$$

O
(
log
n
)

colors. Our results serve as a common generalization and strengthening of many earlier results, including ones about proper and conflict-free coloring points with respect to pseudo-disks, coloring regions of linear union complexity with respect to points and coloring disks with respect to disks.
Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data
Authors: Campioni M. , Agirrezabal I. , Hajek R. , Minarik J. , Pour L. , Spicka I. , Gonzalez-McQuire S. , Jandova P. , Maisnar V. 
Published: October 2019

AbstractObjectiveTo predict the real-world (RW) cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) in relapsed multiple myeloma (MM) patients after one to three prior therapies.MethodsA partitioned survival model that included three health states (progression-free, progressed disease and death) was built. Progression-free survival (PFS), overall survival (OS) and time to discontinuation (TTD) data for the Rd arm were derived using the Registry of Monoclonal Gammopathies in the Czech Republic; the relative treatment effects of KRd versus Rd were estimated from the phase 3, randomised, ASPIRE trial, and were used to predict PFS, OS and TTD for KRd. The model was developed from the payer perspective and included drug costs, administration costs, monitoring costs, palliative care costs and adverse-event related costs collected from Czech sources.ResultsThe base case incremental cost effectiveness ratio for KRd compared with Rd was €73,156 per quality-adjusted life year (QALY) gained. Patients on KRd incurred costs of €117,534 over their lifetime compared with €53,165 for patients on Rd. The QALYs gained were 2.63 and 1.75 for patients on KRd and Rd, respectively.ConclusionsCombining the strengths of randomised controlled trials and observational databases in cost-effectiveness models can generate policy-relevant results to allow well-informed decision-making. The current model showed that KRd is likely to be cost-effective versus Rd in the RW and, therefore, the reimbursement of KRd represents an efficient allocation of resources within the healthcare system.
The Electronic Monitoring of Offenders in Context: From Policy to Political Logics
Authors: Laurie Emma , Maglione Giuseppe 
Published: October 2019

AbstractThe electronic monitoring (EM) of offenders is a subject that has been researched widely within criminology. Theoretical engagement with this instrument has been limited, however. The criminological literature, in fact, has focused primarily on empirical assessments of EM’s financial and technical aspects, as well as on the legal implications of EM and its impact on reoffending. Against this backdrop, this article provides a critical examination of EM, focussing on how policy construes this penal measure, using Scotland as an example. In addition, drawing on Foucault’s notion of governmentality, this article explores and problematizes the political logics (neoliberal, nationalist and techno-communitarian) which inform EM policy in the context of Scotland. The final section shifts the focus from exposing the political milieu within which EM policy emerges to contesting its possible effects, thereby extending the political critique of EM policy. The overarching aim is to contribute toward a nuanced political assessment of EM, while presenting directions for future engagement with this subject.
Students’ trajectories through higher education: a review of quantitative research
Authors: Haas Christina , Hadjar Andreas 
Published: October 2019

AbstractWith the increasing availability of high-quality longitudinal data on students in higher education, scholars’ interest in how students proceed through higher education has risen. So far, the research field is diverse in theoretical perspectives and methodological approaches. Thus, based on 27 studies published in (higher) education research journals during the past two decades, this literature review provides an overview of the theoretical concepts, methodologies and main empirical findings in the study of students’ trajectories in higher education. The results depict a US dominated research field. Most theoretical frameworks are based on student’s decision-making. Across different country contexts and research designs—ranging from descriptions of student trajectories to studies predicting who engages in which types of trajectories to sequential trajectory reconstruction—we found that historically disadvantaged groups in higher education such as students from low social origin follow less linear and less smooth higher education trajectories. However, while the field of comparative education is growing steadily and may significantly contribute to explaining the link between the realization of students’ opportunities and the way how higher education is designed and implemented both on the national and local level, there were no cross-country comparison studies on higher education trajectories.
The Influence of Irrelevant Visual Distractors on Eye Movement Control in Chinese Children with Autism Spectrum Disorder: Evidence from the Remote Distractor Paradigm
Authors: Zhang Li , Yan Guoli , Zhou Li , Lan Zebo , Benson Valerie 
Published: October 2019

AbstractThe current study examined eye movement control in autistic (ASD) children. Simple targets were presented in isolation, or with central, parafoveal, or peripheral distractors synchronously. Sixteen children with ASD (47–81 months) and nineteen age and IQ matched typically developing children were instructed to look to the target as accurately and quickly as possible. Both groups showed high proportions (40%) of saccadic errors towards parafoveal and peripheral distractors. For correctly executed eye movements to the targets, centrally presented distractors produced the longest latencies (time taken to initiate eye movements), followed by parafoveal and peripheral distractor conditions. Central distractors had a greater effect in the ASD group, indicating evidence for potential atypical voluntary attentional control in ASD children.
The Physical, Emotional, and Identity User-Avatar Association with Disordered Gaming: A Pilot Study
Authors: Stavropoulos Vasileios , Dumble Emma , Cokorilo Sandra , Griffiths Mark D. , Pontes Halley M. 
Published: October 2019

AbstractInternet gaming disorder (IGD) is a rapidly expanding psychopathological manifestation necessitating further research and clinical attention. Although recent research has investigated relationships between user-avatar and excessive gaming, little is known about the interplay between IGD and avatar self-presence and its dimensions (i.e., the physical, emotional, and identity bond developed between the user and the in-game character). The aim of the present pilot study was twofold: (i) to investigate the associations between physical, emotional, and identity aspects of self-presence associate and IGD severity, and (ii) to assess IGD variations longitudinally in relation to the three dimensions of self-presence (i.e., proto-self-presence, core-self-presence, and extended-self-presence). The sample comprised 125 young adults aged between 18 and 29 years who underwent either (i) three offline measurements (1 month apart, over 3 months) or (ii) a cross-sectional online measurement. Regression and latent growth analysis indicated that the initial intensity of the physical, emotional, and identity self-presence aspects associated with IGD severity, but not to its longitudinal change. Overall, young adult gamers may exhibit higher IGD risk and severity when the experience of physical, emotional, and identity bonding with their in-game character is pronounced. The implications surrounding treatment and preventative policy recommendations are further discussed.
A novel RBF-based predictive tool for facial distraction surgery in growing children with syndromic craniosynostosis
Authors: Angullia F. , Fright W. R. , Richards R. , Schievano S. , Linney A. D. , Dunaway D. J. 
Published: October 2019

Abstract

Purpose
Predicting changes in face shape from corrective surgery is challenging in growing children with syndromic craniosynostosis. A prediction tool mimicking composite bone and skin movement during facial distraction would be useful for surgical audit and planning. To model surgery, we used a radial basis function (RBF) that is smooth and continuous throughout space whilst corresponding to measured distraction at landmarks. Our aim is to showcase the pipeline for a novel landmark-based, RBF-driven simulation for facial distraction surgery in children.

Methods
An individual’s dataset comprised of manually placed skin and bone landmarks on operated and unoperated regions. Surgical warps were produced for ‘older’ monobloc, ‘older’ bipartition and ‘younger’ bipartition groups by applying a weighted least-squares RBF fitted to the average landmarks and change vectors. A ‘normalisation’ warp, from fitting an RBF to craniometric landmark differences from the average, was applied to each dataset before the surgical warp. The normalisation was finally reversed to obtain the individual prediction. Predictions were compared to actual post-operative outcomes.

Results
The averaged change vectors for all groups showed skin and bone movements characteristic of the operations. Normalisation for shape–size removed individual asymmetry, size and proportion differences but retained typical pre-operative shape features. The surgical warps removed the average syndromic features. Reversing the normalisation reintroduced the individual’s variation into the prediction. The mid-facial regions were well predicted for all groups. Forehead and brow regions were less well predicted.

Conclusions
Our novel, landmark-based, weighted RBF can predict the outcome for facial distraction in younger and older children with a variety of head and face shapes. It can replicate the surgical reality of composite bone and skin movement jointly in one model. The potential applications include audit of existing patient outcomes, and predicting outcome for new patients to aid surgical planning.
Did Alexander Fleming Deserve the Nobel Prize?
Authors: Sand Martin 
Published: October 2019

Abstract
Penicillin is a serendipitous discovery par excellence. But, what does this say about Alexander Fleming’s praiseworthiness? Clearly, Fleming would not have received the Nobel Prize, had not a mould accidently entered his laboratory. This seems paradoxical, since it was beyond his control. The present article will first discuss Fleming’s discovery of Penicillin as an example of moral luck in science and technology and critically assess some common responses to this problem. Second, the Control Principle that says that people are not responsible for things beyond their control will be defended. An implication of this principle is that Alexander Fleming’s desert, which is based on his epistemic skills, remains untouched by luck. Third, by distinguishing different notions of praiseworthiness, a way to resolve the paradox of moral luck will be elaborated. Desert provides only a pro tanto reason to determine whether someone is an appropriate addressee of reward. Here, luck can make a difference. Forth, it will be argued that stimulating the quest for socially beneficial science provides a compelling reason to treat scientists with equal desert differently. Penicillin provides striking evidence for the importance of this quest and showcasing it incentivizes the making of socially beneficial science. Ultimately, it will be justified why Fleming deserved the Nobel Prize in at least one sense of the concept.
Meta-analysis of Nekton Recovery Following Marsh Restoration in the Northern Gulf of Mexico
Authors: Hollweg Terill A. , Christman Mary C. , Lipton Joshua , Wallace Bryan P. , Huisenga Mary T. , Lane Diana R. , Benson Kristopher G. 
Published: October 2019

Abstract
To investigate regional patterns in marsh recovery following restoration, a meta-analysis of nekton densities at restored and reference marshes in the northern Gulf of Mexico (GOM) was conducted. Results were variable at both restored and reference sites, but general trends with respect to the age of the restored site were observed. Pooled together, mean total nekton density in restored marshes during the first 5 years following restoration was approximately 50% of reference marsh densities [95% confidence interval (CI): 26.6–93.0%]. Mean total nekton density in restored marshes in subsequent years (age of restored sites: 6 to 30 years) was approximately 73% of reference marsh densities (95% CI: 46.1–116.1%). Relative densities of crustaceans in restored marshes tended to be lower than in reference marshes during both the initial 5 years following restoration (mean = 36%; 95% CI: 16.6–76.7%) and in subsequent years (mean = 71%; 95% CI: 42.7–119.2%). Mean densities of fish species also tended to be somewhat lower in restored marshes than in reference marshes, but relative densities were highly variable during both the initial 5-year period (mean = 85%; 95% CI: 33.5–215.3%) and in subsequent years (mean = 77%; 95% CI: 39.3–152.7%). A generally increasing trend in total nekton and total crustacean densities was observed over the first 15 years following restoration; mean densities at restored sites were comparable to paired reference locations by approximately year 13. Findings from this study indicate that marsh restoration may not consistently result in nekton production similar to that of natural sites, particularly in the earlier years following restoration when baseline ecosystem processes are developing.
Instantaneous Effects of Sediment Resuspension on Inorganic and Organic Benthic Nutrient Fluxes at a Shallow Water Coastal Site in the Gulf of Finland, Baltic Sea
Authors: Niemistö Juha , Lund-Hansen Lars Chresten 
Published: October 2019

Abstract
Climate change is leading to harsher resuspension events in shallow coastal environments influencing benthic nutrient fluxes. However, we lack information on the quantitative connection between these fluxes and the physical forces. Two identical experiments that were carried out both in May and August provided novel knowledge on the instantaneous effects of resuspension with known intensity on the benthic dissolved inorganic (phosphate: DIP, ammonium: NH4+, nitrite+nitrate: NOx, silicate, DSi) and organic nutrient (phosphorus: DOP, nitrogen: DON, carbon: DOC) fluxes in the shallow soft bottoms of the archipelago of Gulf of Finland (GoF), Baltic Sea. Resuspension treatments, as 2 times the critical shear stress, induced effluxes of one to two orders of magnitude higher than the diffusive fluxes from the studied oxic bottoms. The presence of oxygen resulted in newly formed iron oxyhydroxides and the subsequent precipitation/adsorption of the redox-dependent nutrients (DIP, DSi, organic nutrients) affecting their fluxes. Resuspension-induced NH4+ and NOx fluxes were associated with the organic content of sediments showing the highest values at the organic rich sites. NH4+ showed the strongest responses to resuspension treatments in August, but NOx at the time of high oxygen concentrations in near-bottom water in May. Foreseen increases in the frequency and intensity of resuspension events due to climate change will most likely enhance the internal nutrient loading of the studied coastal areas. The fluxes presented here, connected to known current velocities, can be utilized in modeling work and to assess and predict the internal nutrient loading following climate change.
Start current and growth rate in Smith–Purcell free-electron laser with dielectric-loaded cylindrical grating
Authors: Rezaei Zahra , Farokhi Bizhan 
Published: October 2019

Abstract
We present an analytic theory for Smith–Purcell device in which a cylindrical metal–dielectric grating was derived by an annular electron beam propagating along the grating axis. A dispersion relation is obtained for azimuthally symmetric modes. Also, the first-order and second-order growth rates of the modes which are in phase with the beam are compared. It is shown that the second-order growth rate gives a more accurate description of beam–wave interaction for beams with larger thicknesses, as well as grating slots, with smaller depths and greater lengths. The start current for BWO operation of the SP-FEL is presented too. The importance of the minimum value of start current is that above it, the SP-FEL will operate as an oscillator, even in the absence of external feedback. In this case, the group velocity of the synchronous evanescent wave is negative, while the electron beam travels in the forward direction. It is shown in this paper that the dielectric and grating parameters affect the value of start current. So, by changing these parameters, the minimum value for the start current can be obtained.
Real numbers are the hidden variables of classical mechanics
Authors: Gisin Nicolas 
Published: October 2019

Abstract
Do scientific theories limit human knowledge? In other words, are there physical variables hidden by essence forever? We argue for negative answers and illustrate our point on chaotic classical dynamical systems. We emphasize parallels with quantum theory and conclude that the common real numbers are, de facto, the hidden variables of classical physics. Consequently, real numbers should not be considered as “physically real” and classical mechanics, like quantum physics, is indeterministic.
Influence of Rib Stiffness and Limited Long-Term Junction Strength on Geogrid Performance
Authors: Müller Werner , Wöhlecke Andreas 
Published: October 2019

Abstract
The description of the behavior of geogrids in reinforced soil constructions usually ignores long-term behavior and possible failure modes of junctions between longitudinal and transverse ribs. Two proposals have been made during recent years to overcome this drawback. The first analytic approach applies only to rigid geogrids and assumes a specific tensile-shear failure mode of geogrid junctions. The second numerical approach applies also for non-rigid geogrids and takes into account different modes of junction failure. This note discusses the two approaches focusing on the effects of rib stiffness and limited strength, different failure modes and degradation of junctions. It is shown that the mentioned effects should be considered in geogrid design, because they may alter significantly the long-term geogrid performance.
Extending belief research to adult basic education: an exploration of some adult educators’ beliefs about numeracy and its teaching
Authors: Beeli-Zimmermann Sonja 
Published: October 2019

AbstractWhile belief research has become an integral part of the educational research agenda, it has been uneven. One neglected area is the beliefs of adult education teachers. Focusing on five such teachers working in adult basic education and teaching numeracy in Switzerland, this exploratory study uses different data to describe their beliefs about numeracy and its teaching. It is shown that this group holds clearly different views from other groups of adult teachers and it is argued that extending belief research to this target group using different approaches could contribute to a wider knowledge base on beliefs in general.