bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining Clusters of Young Autistic and Typically-Developing Children Based on Loudness-Dependent Auditory Electrophysiological Responses
Authors: Dwyer Patrick , Wang Xiaodong , De Meo-Monteil Rosanna , Hsieh Fushing , Saron Clifford D. , Rivera Susan M. 
Published: April 2020

Abstract
Background: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in Typical Development (TD) alongside Autism Spectrum Development (ASD). Methods: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically-developing children based the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80 dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. Results: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically-developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70 dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically-developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60 dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80 dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with both auditory distractibility and noise distress. This appears to provide evidence of coinciding behavioural and neural sensory atypicalities. Limitations : Replication may be needed to verify exploratory results. This analysis may ignore some variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Variability in sensory responses unrelated to loudness is ignored, leaving much room for additional research. Conclusions: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviours, cognitive abilities, and autism diagnostic status.
Clinical outcomes of early gastric cardiac cancer treated with endoscopic submucosal dissection in patients with different indications
Authors: Fan Ting , Sun Qi , Cao Shouli , Fan Xiangshan , Huang Qin , Zhang Shu , Lv Ying , Zhang Xiaoqi , Ling Tingsheng , Wang Lei , Xu Guifang , Zou Xiaoping 
Published: April 2020

Abstract
Background: Endoscopic submucosal dissection (ESD) has been accepted as a standard treatment for early gastric cardiac cancer (EGCC). Here, we investigate the clinical outcomes of the EGCC patients who underwent ESD in different indications. Methods: From January 2011 to October 2019, we enrolled 502 EGCC lesions from 495 patients which were resected by ESD at our center. We retrospectively analyzed the short-term and long-term clinical outcomes among different indication groups. Results: The number of the patients in the absolute indication (AI), expanded indication (EI) and beyond the expanded indication (BEI) groups was 265, 137 and 93, respectively. The en bloc resection rate was 100%, 100% and 98.9% ( P =0.185). The complete resection rate was 99.3%, 98.5% and 74.5%, respectively ( P <0.001). During a median follow-up of 48.1 months, the lymph node metastasis rate was 0%, 0% and 2.3% ( P <0.001). The distant metastasis rate was 0.4%, 0% and 2.3% ( P =0.150). The five-year disease-specific survival rate in the BEI group was 96.6% ( P =0.016), compared to 99.6% in the AI group and 100% in the EI group. Conclusion: The efficacy for ESD patients in EI group was almost equal to the AI group. Patients in the BEI group showed generally favorable clinical outcomes and needed to be carefully checked after ESD. ESD may be an optional treatment for patients unsuitable for gastrectomy.
Comparison of Antimicrobial Resistance in Patients with Obstructive Pyelonephritis Associated with Ureteral Stones and Uncomplicated Pyelonephritis
Authors: Oh Ji-sun , Ahn Su Joa , Won Jeongyeon , Han Jung , Eom Joong Sik , Chung Wookyung , Cho Yong Kyun , Jang Young-Rock 
Published: April 2020

Abstract
Background

This study aimed to investigate the clinical outcomes and antibiotic susceptibilities of causative microorganisms in patients with obstructive pyelonephritis associated with ureteral stones (OPU).
Methods

This retrospective cohort study included female patients diagnosed with community-acquired acute pyelonephritis (APN) at a tertiary care hospital from 2008 to 2017. Cases of APN associated with obstruction of the upper urinary tract due to the presence of ureteral stones and cases of APN without complications were compared. Propensity score matching was used to adjust for heterogeneity within each group.
Results

Of the 588 female patients with community-acquired APN, 107 patients were diagnosed with OPU and 481 patients were diagnosed with uncomplicated APN. Propensity score matching revealed that Enterobacteriaceae strains isolated from OPU cases were more resistant to fluoroquinolones (51.9% vs. 16.0%, p < 0.001). Extended-spectrum β-lactamase was detected in 22.2% and 21.0% of the Enterobacteriaceae strains isolated from OPU cases and uncomplicated APN cases, respectively (p = 1.000). The treatment failure rate was similar in the OPU and uncomplicated APN groups (16.0% vs. 21.0%, p = 0.545).
Conclusions

Antibiotic treatment for patients with OPU may be empirically selected in accordance with the treatment protocol for general pyelonephritis. Clinicians should exercise caution before prescribing fluoroquinolones for the treatment of OPU.
Estimation of the Ideal Correction of Lumbar Lordosis to Prevent Reoperation for Symptomatic Adjacent Segment Disease After Lumbar Fusion in Older People
Authors: Wang Shan-Jin , Zhang Shu-Bao , Yi Yu-Yang , Xu Hao-Wei , Wu De-Sheng 
Published: April 2020

Abstract
Background
Symptomatic adjacent segment disease (ASDis) is a major complication following spinal fusion. Sagittal spinopelvic imbalance may contribute to the development of ASDis. However, the exact ideal correction of LL is unknown for different ages of people to prevent ASDis. The purpose of this study was to estimate the ideal correction of lumbar lordosis (LL) required to prevent symptomatic ASDis requiring revision surgery in patients of various ages, and to determine the radiographic risk factors for ASDis.
Method
468 patients who underwent lumbar fusion between January 2014 and December 2016, were enrolled in the present study. The patients were classified into the ASDis and N-ASD group. These two matched groups were compared regarding surgery-related factors and radiographic features. Multivariate logistic regression analysis was used to evaluate the risk factors for ASDis.
Results
Sixty-two patients (13.25%) underwent reoperation for ASDis during a mean follow-up duration of 38.07 months. Receiver operating characteristic curve analysis showed that the postoperative LL - preoperative LL (△LL) cutoff value was 11.7°for the development of ASDis. Logistic regression analysis revealed that the risk factors for symptomatic ASDis were a smaller LL angle, △LL > 12°, and PI-LL > 10° (p < 0.05). For patients > 60 years, the incidence of ASDis was higher in patients with a LL correction of ≥ 10° and a lumbar-pelvic mismatch (PI-LL) of > 20°.
Conclusions
The significant predictors of the occurrence of ASD were a smaller LL angle, △LL > 12°, and PI-LL > 10°. However, in patients older than 60 years, the incidence of ASD after lumbar fusion was higher in those with a LL correction of ≥ 10° and PI-LL of > 20°. More attention should be paid to patient age and the angle of correction of LL before lumbar fusion.
Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients
Authors: Zhao Xuemin , Bie Mengjun 
Published: April 2020

Abstract
Background
Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI).
Objective
We aim to investigate predictors of the development of OI in the patients with AAD.
Methods
We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index ≤ 200) and OI (-) group (oxygenation index > 200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve.
Results
A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85 ± 0.60 vs 37.64 ± 0.44℃, P = .005), higher levels of CRP (42.70 ± 28.27 vs 13.90 ± 18.70 mg/L, P = .000) and procalcitonin (1.07 ± 3.92 vs 0.31 ± 0.77ug/L, P = .027), and lower levels of albumin (34.21 ± 5.65 vs 37.73 ± 4.70 g/L, P = .000). Spearman’s rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥ 9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%.
Conclusions
The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission ≥ 9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.
Tubeless versus common minimally invasive percutaneous nephrolithotomy for renal stones under local anesthesia: analysis of clinical outcomes
Authors: Qu GenYi , Xu Yong , Tang Cheng , Liu JinGe , Nie HaiBo , Jiang XiuFang , Huang WenLin , Yang Guang 
Published: April 2020

Abstract
Background: To compare the clinical outcomes of tubeless minimally invasive percutaneous nephrolithotomy（mPCNL）and common minimally invasive percutaneous nephrolithotomy under local anesthesia, and to explore the feasibility, safety and clinical efficacy of tubeless mPCNL under local anesthesia. Methods: Patients with PCNL who underwent local anesthesia from January 1, 2018 to November 30, 2018. The patients were divided into Group 1 (tubeless mPCNL: indwelling double J tube, no indwelling nephrostomy tube) and group 2 (common mPCNL: indwelling double J tube and nephrostomy tube). The intraoperative and postoperative parameters of the two groups were compared, including operation time, average postoperative hospital stay, puncture position, postoperative hemoglobin decline, postoperative visual analogue scale (VAS), analgesic use, postoperative fever and stone removal rate. Results: In group1,the VAS scores of 6 hours after surgery was 4.07±1.79 significantly lower than that for group 2 (4.07±1.79 vs 6.24±1.33, P<0.05). and There was a statistically significant difference in the use of analgesics between the two groups（P<0.05）. The VAS scores of day 1 after surgery (2.50±1.76 vs 3.83±2.22 in group1 and group2) was significantly lower in the tubeless mPCNL (P<0.05). The hospital stay for group 1 was significantly shorter than group 2(3.15±1.42 vs 6.48±1.88 days, P<0.01)). There were no significant differences in the operation time, puncture position, postoperative hemoglobin decline rate, VAS score on the day of discharge, postoperative fever, and stone removal rate between the two groups (P>0.05). Conclusion: Tubeless mPCNL is a simple, safe and effective technique under local anesthesia. It is worthy of clinical application. Tubeless mPCNL treatment for renal stones can significantly reduce postoperative pain and shorten hospital stays compared with common m PCNL.
Combined support mechanism of rock bolt and anchor cable for adjacent roadways in the external staggered split-level panel layout
Authors: Batugin Adrian , Zhiqiang Wang , Zehua Su , Sidikovna Shermatova Sayyora 
Published: April 2020

Abstract
Utilizing the spatial structure characteristics of the external staggered split-level panel layout, the combined support technology of adjacent roadways is proposed, and combined support mechanism of rock bolt and anchor cable were analyzed. The influence of the side rock bolt and anchor cable parameters respectively on the mechanical properties of the anchorage body and support stress distribution of lateral coal body was revealed through FLAC3D software. The optimal support parameters of side rock bolt and anchor cable were determined subsequently. And the support effect of the gob-side entry under mining influence was verified. Result shows that the support effect of side rock bolt and anchor cable can improve the mechanical properties and the stress state of the anchorage body, which has a good protective effect on the coal body of the air-intake entry roof and side wall. It is beneficial to the stability of the side wall and the realization of the suspension effect for the roof rock bolt and anchor cable, which makes the surrounding rock maintenance of the gob-side entry of the thick coal seam more favorable.
A prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01)
Authors: Itano Osamu , Takemura Yusuke , Kishida Norihiro , Tamagawa Eiji , Shinozaki Hiroharu , Ikeda Ken , Urakami Hidejiro , Ei Shigenori , Hayatsu Shigeo , Suzuki Keiichi , Sakuragawa Tadayuki , Ishii Masatsugu , Shito Masaya , Aiura Koichi , Fujisaki Hiroto , Takano Kiminori , Matsui Junichi , Minagawa Takuya , Shinoda Masahiro , Kitago Minoru , Abe Yuta , Yagi Hiroshi , Oshima Go , Hori Shutaro , Kitagawa Yuko 
Published: April 2020

Abstract
Background: Although surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been satisfactory. Adjuvant therapy with S-1 may improve survival in patients with BTC. This study examined the safety and efficacy of 1 year adjuvant S-1 therapy for BTC in a multi-institutional trial.Methods: The inclusion criteria were as follows: histologically proven BTC, ECOG performance status 0 or 1, R0 or R1 surgery performed, cancer classified as Stage IB to III. Within 10 weeks post-surgery, a 42-day cycle of treatment with S-1 (80 mg/m2/day orally twice daily on days 1–28 of each cycle) was initiated and continued up to 1 year post surgery. The primary endpoint was adjuvant therapy completion rate. The secondary endpoints were toxicities, disease-free survival (DFS) and overall survival (OS).Results: Overall, 46 patients met the inclusion criteria of whom 19 had extrahepatic cholangiocarcinoma, 10 had gallbladder carcinoma, 9 had ampullary carcinoma, and 8 had intrahepatic cholangiocarcinoma. Overall, 25 patients completed adjuvant chemotherapy, with a 54.3% completion rate while the completion rate without recurrence during the 1 year administration was 62.5%. Seven patients (15%) experienced adverse events (grade 3/4). The median number of courses administered was 7.5. Thirteen patients needed dose reduction or temporal therapy withdrawal. OS and DFS rates at 1/2 years were 91.2/80.0% and 84.3/77.2%, respectively. Among patients who were administered S-1 more than 3 courses, only one case discontinued due to adverse events.Conclusions: One-year administration of adjuvant S-1 therapy for resected BTC was feasible and may be a promising treatment for those with resected BTC. Now, a randomized trial to determine the optimal duration of S-1 is ongoing.Trial registration: UMIN-CTR, UMIN000009029. Registered 5 October 2012-Retrospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000009347)
What Parents Expect when Requesting an Autism Spectrum Disorder Assessment of their Young Child: an In-Depth Interview Study
Authors: Jacobs Delphine , Steyaert Jean , Dierickx Kris , Hens Kristien 
Published: April 2020

Abstract
Background
Parents are valued stakeholders in research, clinical practice and policy development concerning autism spectrum disorder (ASD). Little is known, however, about what drives and moves parents when they request a diagnostic ASD assessment of their child.
Methods
Seventeen Flemish parents of 11 young children participated in a longitudinal study consisting of three in-depth interviews before and after their child’s diagnostic ASD assessment. Data were analysed in Nvivo 11 according to the procedures of Interpretative Phenomenological Analysis.
Results
In this paper we report the results of the first series of interviews which were conducted after parents had asked for an ASD assessment of their young child, and before this assessment started. The pre-assessment experiences of the parents were dominated by the anticipation of various implications of an ASD diagnosis, comprising both positive and negative expectations. The theme of positive expectations consisted of two equally prominent subthemes: treatment-related implications but also psycho-relational expectations.
Conclusions
This study suggests important issues for clinicians to bear in mind during a consultation with parents who request an ASD assessment of their young child. We argue that attending to and communicating about parents’ expectations prior to their child’s ASD assessment may help clinicians to better understand parents’ requests for help, and to address their needs more effectively.
Assessment and associated factors of suicidal behaviour among cancer patients visiting the oncology outpatient unit in Mekelle oncologic clinics, Tigray, Ethiopia: a cross−sectional study
Authors: Gebreselassie abreha Tsegay , metekiya workua mekonen , beyene birhane gebrehiwot 
Published: April 2020

Abstract
Background

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. According to estimates from the International Agency for Research on Cancer, there will be 17.0 million new cancer cases in 2018 worldwide. Depression, age, sex, divorced, and hopelessness are of most factors can patient with cancer result in suicidal behaviour. The purpose of this study is to identify and associated factors of suicidal behaviour among cancer patients in Mekelle, Ethiopia.
Methods

The cross-sectional study design was employed with a total of 345 study subjects in Mekelle, Ethiopia. Suicidal behaviour was measured by the Suicidal Behavior Questionnaire-Revised (SBQ-R) scale. Bivariate and multiple logistic regression analyses were performed to determine between the explanatory and outcome variables.
Results

The magnitude of suicidal behaviour was 20%. Previously suicidal attempt [AOR = 31.466, 95% CI (14.552, 68.042), P < 0.0001] was associated factor whereas no comorbid physical illness [AOR = .0.363, 95% (0. 164, 0.806)] and current treatment regimen (surgery, radiotherapy and palliative care) were significantly protective factors for suicidal behavior.
Conclusion

No comorbid physical illness, suicide attempt and current treatment regimen were significant factors of suicidal behaviour. Oncologic professionals should assess patient suicidal risk assessment routinely and every professional focuses on management besides the medication.
Functional Status of Hypothalamic-pituitary-thyroid axis and Prolactin level in Patients with First-episode of Bipolar Disorder in Mania State
Authors: Wang Fang , Zhang Huaihui , Wang Jun , Zhao Dongmei , Zhu Yuncheng 
Published: April 2020

Abstract
Background

Bipolar disorder (BD)-mania symptoms are stimulated by disease of the thyroid.
Methods

This study included 70 patients diagnosed with first-episode BD-mania and 70 healthy controls (HC) matched for age and sex. We aimed to determine upstream thyroid hormone interactions on the anterior pituitary, and find differences between thyroid-stimulating-hormone (TSH) and Prolactin (PRL) in the patients with first-episode of BD-mania. There were significant changes in triiodothyronine (TT3), total thyroxin (TT4), and free thyroxine (FT4) concentrations between the BD-mania and HC groups (p < 0.0167 with Bonferroni correction).
Results

After being grouped by sex, higher PRL in the male and female BD-mania subgroup were observed compared to each isosexual HC (p’s < 0.01). Higher FT4 in the male BD-mania group was observed compared to the HC males (p < 0.01) while the female BD-mania group showed lower TT3 and TT4 compared to the HC females (p’s < 0.01). In the female BD-mania group, correlation analysis established an inverse relationship between PRL and TSH (r2 = 0.25, F = 11.11, p < 0.01).
Conclusions

The findings demonstrate that sex impacts the concentration of hormones secreted by the anterior pituitary of patients with first-episode BD-mania. The increased PRL may be a putative mechanism that underlies the onset in female patients with a moderate inverse relationship between TSH and PRL.
Nomogram for predicting cancer-specific survival of patients with buccal squamous cell carcinoma: a population-based study
Authors: Wang Wei-Ming , chu xiuhong , yang sisi , wang ying , hu chuanyu 
Published: April 2020

Abstract
Background

The use of the traditional American Joint Committee on Cancer (AJCC) staging system alone has limitations in predicting the survival of buccal squamous cell carcinoma (BSCC) patients. We aimed to establish a comprehensive prognostic nomogram whose prognostic value compared with AJCC system.
Methods

Patients were obtained from the SEER (Surveillance, Epidemiology, and End Result) database. The Cox regression model was used to select variables using a backward stepwise selection method. Based on the predictive model for determining prognostic factors, a nomogram was developed to predict the cancer-specific survival rates of BSCC patients at 3, 5 and 8 years. We used several standard model validation methods to evaluate the performance of the survival model: concordance index (C-index), area under the time-dependent receiver operating characteristic curve (AUC), net reclassification improvement (NRI), calibration plots, decision curve analyses (DCAs), and integrated discrimination improvement (IDI).
Results

Multivariate analysis showed that age, AJCC stage, N stage, M stage, pathological grade, and surgical status were risk factors for survival. The c-index chart, the AUC chart, and the calibration chart show that the performance of the nomogram is better, and the NRI and IDI values show that the performance of the nomogram is better than that of the AJCC staging system. The 3-year, 5-year and 8-year DCA curves of nomogram show that it has more net benefit than traditional AJCC staging system, both in terms of training and validation queues.
Conclusion

We developed and validated the first BSCC prognosis nomogram, which has a better prognostic value than the separate AJCC staging system. Our BSCC prognosis nomogram is a valuable tool for explaining the risks of the next 3, 5 and 8 years in clinical practice.