bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking
Authors: Parslow Roxanne M. , Anderson Nina , Byrne Danielle , Haywood Kirstie L. , Shaw Alison , Crawley Esther 
Published: January 2020

AbstractPurposeChronic fatigue syndrome (CFS)/myalgic encephalopathy (ME) is relatively common in children and is disabling at an important time in their development. This study aimed to develop a conceptual framework of paediatric CFS/ME using the patient-perspective to ensure that the content of a new outcome measure includes the outcomesmostimportant to young people.MethodsWe developed a child-centred interactive card ranking exercise that included health-related quality of life (HRQoL) outcomes identified from a previous review of the literature as well as qualitative work. Adolescents and their parents selected and ranked the outcomes most important to them and discussed each outcome in further detail. Adolescents were purposively sampled from a single specialist paediatric CFS/ME service in England. Interviews were audio recorded and transcribed verbatim, and thematic framework analysis was used to develop the final conceptual framework.ResultsWe interviewed 43 participants in which there are 21 adolescents, 12–17 years of age with mild–moderate CFS/ME and their parents (20 mothers and 2 fathers). ‘Symptoms’, ‘tiredness’, ‘payback and crashing’ and ‘activities and hobbies’ were ranked most important to improve by both children and parents. Children ranked ‘school’ higher than parents and parents ranked ‘mood’ higher than children. A youth- specific CFS/ME conceptual framework of HRQoL was produced that included 4 outcome domains and 11 subdomains: sleep, tiredness, problems concentrating, individual symptoms, fluctuation and payback, daily and general activities, participation in school, leisure and social life, mood, anxiety and self-esteem.ConclusionsAn interactive card ranking exercise worked well for adolescents aged 12–17 to elicit the most important outcomes to them and explore each domain in further detail. We developed a final conceptual framework of HRQoL that forms the basis of a new paediatric patient-reported outcome measure (PROM) in CFS/ME.
Measuring Teacher Sense of Efficacy: Insights and Recommendations Concerning Scale Design and Data Analysis from Research with Preservice and Inservice Teachers in China
Authors: Ma Kang , Trevethan Robert , Lu Shuhong 
Published: January 2020

AbstractIn this study, issues concerning the design of scales for measuring teacher sense of efficacy (TSE) are first identified with particular attention to the Teacher Sense of Efficacy Scale (TSES). Psychometric issues concerning analysis and reporting of TSE data are subsequently identified. Recommendations are offered about all identified issues, and these recommendations are taken into account when obtaining and analyzing TSE data from Chinese mainland preservice and inservice teachers. Exploratory factor analyses yielded a single factor for both samples as well as for four subgroups within the inservice teacher sample. Results also provided insights about scale design as well as the TSES being limited for capturing the breadth of TSE. Suggestions are made for improvements in the assessment of TSE.
Energy Consumption and Greenhouse Gas Emissions During Ferromolybdenum Production
Authors: Wei Wenjing , Samuelsson Peter B. , Tilliander Anders , Gyllenram Rutger , Jönsson Pär G. 
Published: January 2020

AbstractMolybdenum is mainly used as an alloy material in the iron and steel industry and typically in the form of ferromolybdenum (FeMo). The current study aims to evaluate the energy consumption and greenhouse gas emissions (GHG) of four ferromolybdenum production cases using inventory inputs from a process model based on mass and energy conservations. The total energy required for producing 1 tonne of FeMo can vary between 29.1 GJ/t FeMo and 188.6 GJ/t FeMo. Furthermore, the corresponding GHG emissions differ from 3.16 tCO2-eq/t FeMo to 14.79 tCO2-eq/t FeMo. The main variances are from the mining and beneficiation stages. The differences in these stages come from the beneficiation degree (ore grade) and the mine type (i.e., co-product from copper mining). Furthermore, the mine type has a larger impact on the total energy consumption and GHG emissions than the beneficiation degree. More specifically, FeMo produced as co-product from copper mining has a lower environmental impact measured as the energy consumption and GHG emission among all the four cases. The inventory, consumed energy or associated GHG emission is independent on the initial ore grade and mine type in the downstream production stages such as roasting and smelting. Also, transport has the least impact on the energy consumption and GHG emission among all production stages.
Acute whole apple consumption did not influence postprandial lipaemia: a randomised crossover trial
Authors: Lin Xinjie , Liddle Danyelle M. , Neizer Hannah R. , Robinson Lindsay E. , Wright Amanda J. 
Published: January 2020

AbstractWhole apples are a source of pectin and polyphenols, both of which show potential to modulate postprandial lipaemia (PPL). The present study aimed to explore the effects of whole apple consumption on PPL, as a risk factor for CVD, in generally healthy but overweight and obese adults. A randomised, crossover acute meal trial was conducted with seventeen women and nine men (mean BMI of 34·1 (sem 0·2) kg/m2). Blood samples were collected for 6 h after participants consumed an oral fat tolerance test meal that provided 1 g fat/kg body weight and 1500 mg acetaminophen per meal for estimating gastric emptying, with and without three whole raw Gala apples (approximately 200 g). Plasma TAG (with peak postprandial concentration as the primary outcome), apoB48, chylomicron-rich fraction particle size and fatty acid composition, glucose, insulin and acetaminophen were analysed. Differences between with and without apples were identified by ANCOVA. Apple consumption did not alter postprandial TAG response, chylomicron properties, glucose or acetaminophen (P > 0·05), but did lead to a higher apoB48 peak concentration and exaggerated insulin between 20 and 180 min (P < 0·05). Overall, as a complex food matrix, apples did not modulate postprandial TAG when consumed with a high-fat meal in overweight and obese adults, but did stimulate insulin secretion, potentially contributing to an increased TAG-rich lipoprotein production.
Investment performance, regulation and incentives: the case of Chilean pension funds
Authors: López Fernando , Walker Eduardo 
Published: January 2020

AbstractWe examine the investment performance of Chilean pension funds during their multi-fund period (2003–17). Using tradable asset class benchmarks, we extend Sharpe's (1992) return-based style analysis by explicitly considering regulatory restrictions and currency hedging. We find that despite the significant differences between pension fund manager returns, they are statistically similar to our style benchmarks for all fund types. Furthermore, accounting for currency hedging improves the accuracy of the replicating portfolios and the selection return estimates. Our results have policy implications for investment regulation of pension systems with similar characteristics to the Chilean one.
Chiral emission and Purcell enhancement in a hybrid plasmonic-photonic microresonator
Authors: Cao Qi-Tao , Chen You-Ling , Xiao Yun-Feng 
Published: January 2020

AbstractA high-Q hybrid plasmonic-photonic microresonator, which consists of a dielectric microdisk hybridized with a plasmonic nanoantenna dimer, enables an enlarged local density of states of the optical field and chiral propagation of photons inside the cavity.
Evidence for phylogenetically and catabolically diverse active diazotrophs in deep-sea sediment
Authors: Kapili Bennett J , Barnett Samuel E , Buckley Daniel H , Dekas Anne E 
Published: January 2020

Abstract
Diazotrophic microorganisms regulate marine productivity by alleviating nitrogen limitation. However, we know little about the identity and activity of diazotrophs in deep-sea sediments, a habitat covering nearly two-thirds of the planet. Here, we identify candidate diazotrophs from Pacific Ocean sediments collected at 2893 m water depth using 15N-DNA stable isotope probing and a novel pipeline for nifH sequence analysis. Together, these approaches detect an unexpectedly diverse assemblage of active diazotrophs, including members of the Acidobacteria, Firmicutes, Nitrospirae, Gammaproteobacteria, and Deltaproteobacteria. Deltaproteobacteria, predominately members of the Desulfobacterales and Desulfuromonadales, are the most abundant diazotrophs detected, and display the most microdiversity of associated nifH sequences. Some of the detected lineages, including those within the Acidobacteria, have not previously been shown to fix nitrogen. The diazotrophs appear catabolically diverse, with the potential for using oxygen, nitrogen, iron, sulfur, and carbon as terminal electron acceptors. Therefore, benthic diazotrophy may persist throughout a range of geochemical conditions and provide a stable source of fixed nitrogen over geologic timescales. Our results suggest that nitrogen-fixing communities in deep-sea sediments are phylogenetically and catabolically diverse, and open a new line of inquiry into the ecology and biogeochemical impacts of deep-sea microorganisms.
Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
Authors: Rabé Marion , Dumont Solenne , Álvarez-Arenas Arturo , Janati Hicham , Belmonte-Beitia Juan , Calvo Gabriel F. , Thibault-Carpentier Christelle , Séry Quentin , Chauvin Cynthia , Joalland Noémie , Briand Floriane , Blandin Stéphanie , Scotet Emmanuel , Pecqueur Claire , Clairambault Jean , Oliver Lisa , Perez-Garcia Victor , Nadaradjane Arulraj , Cartron Pierre-François , Gratas Catherine , Vallette François M. 
Published: January 2020

AbstractDrug resistance limits the therapeutic efficacy in cancers and leads to tumor recurrence through ill-defined mechanisms. Glioblastoma (GBM) are the deadliest brain tumors in adults. GBM, at diagnosis or after treatment, are resistant to temozolomide (TMZ), the standard chemotherapy. To better understand the acquisition of this resistance, we performed a longitudinal study, using a combination of mathematical models, RNA sequencing, single cell analyses, functional and drug assays in a human glioma cell line (U251). After an initial response characterized by cell death induction, cells entered a transient state defined by slow growth, a distinct morphology and a shift of metabolism. Specific genes expression associated to this population revealed chromatin remodeling. Indeed, the histone deacetylase inhibitor trichostatin (TSA), specifically eliminated this population and thus prevented the appearance of fast growing TMZ-resistant cells. In conclusion, we have identified in glioblastoma a population with tolerant-like features, which could constitute a therapeutic target.
Normal early development in siblings with novel compound heterozygous variants in ASPM
Authors: Moriwaki Taro , Yamazaki Narutoshi , So Tetsumin , Kosuga Motomichi , Miyazaki Osamu , Narumi-Kishimoto Yoko , Kaname Tadashi , Nishimura Gen , Okuyama Torayuki , Fukuhara Yasuyuki 
Published: January 2020

AbstractAutosomal recessive primary microcephaly 5 (MCPH5) is caused by pathogenic variants in ASPM. Using whole-exome sequencing, we diagnosed two siblings with MCPH5. A known pathogenic variant (NM_018136.4: c.9697C > T, p.(Arg3233*)) and a novel pathogenic variant (c.1402_1406del, p.(Asn468Serfs*2)) of ASPM were identified in affected siblings with normal intelligence. Their pathogenic variants were not located in the critical regions of ASPM, but the relationship between the genotypes and their normal intelligence was unclear.
Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro
Authors: Kosyakova Natalia , Kao Derek D. , Figetakis Maria , López-Giráldez Francesc , Spindler Susann , Graham Morven , James Kevin J. , Won Shin Jee , Liu Xinran , Tietjen Gregory T. , Pober Jordan S. , Chang William G. 
Published: January 2020

AbstractFormation of a perfusable microvascular network (μVN) is critical for tissue engineering of solid organs. Stromal cells can support endothelial cell (EC) self-assembly into a μVN, but distinct stromal cell populations may play different roles in this process. Here we describe the differential effects that two widely used stromal cell populations, fibroblasts (FBs) and pericytes (PCs), have on μVN formation. We examined the effects of adding defined stromal cell populations on the self-assembly of ECs derived from human endothelial colony forming cells (ECFCs) into perfusable μVNs in fibrin gels cast within a microfluidic chamber. ECs alone failed to fully assemble a perfusable μVN. Human lung FBs stimulated the formation of EC-lined μVNs within microfluidic devices. RNA-seq analysis suggested that FBs produce high levels of hepatocyte growth factor (HGF). Addition of recombinant HGF improved while the c-MET inhibitor, Capmatinib (INCB28060), reduced μVN formation within devices. Human placental PCs could not substitute for FBs, but in the presence of FBs, PCs closely associated with ECs, formed a common basement membrane, extended microfilaments intercellularly, and reduced microvessel diameters. Different stromal cell types provide different functions in microvessel assembly by ECs. FBs support μVN formation by providing paracrine growth factors whereas PCs directly interact with ECs to modify microvascular morphology.
Interplay of mRNA capping and transcription machineries
Authors: Kachaev Zaur M. , Lebedeva Lyubov A. , Kozlov Eugene N. , Shidlovskii Yulii V. 
Published: January 2020

Abstract
Early stages of transcription from eukaryotic promoters include two principal events: the capping of newly synthesized mRNA and the transition of RNA polymerase II from the preinitiation complex to the productive elongation state. The capping checkpoint model implies that these events are tightly coupled, which is necessary for ensuring the proper capping of newly synthesized mRNA. Recent findings also show that the capping machinery has a wider effect on transcription and the entire gene expression process. The molecular basis of these phenomena is discussed.
Effects of a Simulated Game on Pitching Kinematics in Youth Softball Pitcher
Authors: Downs Jessica , Friesen Kenzie , W. Anz Adam , Dugas Jeffrey R. , R. Andrews James , Oliver Gretchen D. 
Published: January 2020

AbstractDespite evidence that overuse is the most common mechanism of injury, softball pitchers currently have no pitch count regulations. Pain has been associated with certain pitching pathomechanics, and some reports indicate increased pain following a single pitching bout. Therefore, the purpose of this study was to examine trunk and lower extremity kinematics during the first and last inning of a game, as well as last inning pitch volume in youth softball pitchers. Thirty-two youth softball pitchers (12.4±1.6 years, 159.4±8.9 cm, 62.0±13.6 kg) pitched a simulated game. Three fastballs were averaged and analyzed from the first and last inning. Kinematic data were collected at 100Hz using an electromagnetic system, synced with motion analysis software. A Wilcoxon signed rank test revealed pitchers exhibited less trunk rotation toward their pitching arm side in the last inning. A bivariate Pearson’s correlation showed volume of pitches was correlated with stride length (r=0.367, p=0.039) and center of mass (r=0.364, p=0.041) at the start of the pitch, and trunk flexion at top of pitch (r=−0.392, p=0.026), foot contact (r=−0.413, p=0.019), and follow-through (r=−0.436, p=0.013). This study found that pitching a simulated game did result in altered pitching mechanics, meanwhile pitch volume was also correlated with pitching mechanics.
Smith–Magenis Syndrome: Clues in the Clinic
Authors: Akkus Nejmiye , Kilic Betul , Cubuk Pelin Ozyavuz 
Published: January 2020

AbstractAs a multisystemic congenital mental retardation disorder/anomaly, Smith–Magenis syndrome (SMS) is commonly aroused from de novo interstitial deletion of the 17p11.2 chromosome. The deletion of this chromosome results with haploinsufficiency for the retinoic acid-induced 1 (RAI1) gene. In this article, we present three cases, who were diagnosed with SMS with mental retardation and behavioral problems such as self-hugging and sleeping disturbances. During the evaluation of the patients, it has been found that there was a 3.4-Mb deletion in the 17p11.2 chromosome region of these patients. This deletion includes RAI1 that is a critically involved gene in SMS.
Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study
Authors: Maines Evelina , Tadiotto Elisa , Morandi Grazia , Fedrizzi Michela , Gaudino Rossella , Cavarzere Paolo , Guzzo Alessandra , Antoniazzi Franco 
Published: January 2020

AbstractThe use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.
Ophthalmologic Impairment and Intellectual Disability in a Girl Presenting Kenny-Caffey Syndrome Type 2
Authors: Deconte Desirée , Kreusch Tulia Cristina , Salvaro Bruna Pavan , Perin Wagner Fernando , Ferreira Maria Angélica Tosi , Kopacek Cristiane , da Rosa Ernani Bohrer , Heringer Jane Iândora , Ligabue-Braun Rodrigo , Zen Paulo Ricardo Gazzola , Rosa Rafael Fabiano Machado , Fiegenbaum Marilu 
Published: January 2020

AbstractKenny-Caffey syndrome (KCS) is a rare genetic condition characterized by growth retardation, bone abnormalities, and hypoparathyroidism. Herein, we report an unusual case of a 10-year-old girl with Kenny-Caffey syndrome type 2 (KCS2) presenting with vision impairment-suspected maculopathy and intellectual disability. Endocrine evaluation showed low calcium and high phosphorus plasma levels. Radiographic evaluation revealed short metacarpal bones and delayed bone age. Sequencing analysis showed a missense variant in FAM111A (R569H), unidentified in her parents. Better understanding of potential neurological and ophthalmological findings in KCS2 patients is important to improve quality of life of these patients as usually they exhibit long survival.
Peruvian Newborn Male with 3p13 Deletion Syndrome Encompassing the FOXP1 Gene: Review of the Literature
Authors: Abarca-Barriga Hugo H. , Trubnykova Milana , Chavesta-Velásquez Félix , Barletta-Carrillo Claudia , Ordoñez-Linares Marco , Rondón-Abuhadba Andrea 
Published: January 2020

AbstractCopy number variation in loss of 3p13 is an infrequently reported entity characterized by hypertelorism, aniridia, microphthalmia, high palate, neurosensorial deafness, camptodactyly, heart malformation, development delay, autism spectrum disorder, seizures, and choanal atresia. The entity is caused probably by haploinsufficiency for FOXP1, UBA3, FAM19A1, and MITF. We report a newborn male with hypotonia, facial dysmorphism, heart malformation, and without clinical diagnosis; nevertheless, the use of appropriate genetic test, such us the chromosomal microarray analysis allowed identification of a copy number variant in loss of 5.5 Mb at chromosome 3 (p13-p14.1), that included 54 genes, encompassing FOXP1 gene. We compare the findings in our Peruvian patient to those of earlier reported patients; furthermore, add new signs for this entity.
A study on experiment and simulation to predict the spring-back of SS400 steel sheet in large radius of V-bending process
Authors: Gia Hai Vuong , Thi Hong Minh Nguyen , Nguyen Duc Toan 
Published: January 2020

Abstract
The spring-back phenomenon is one of the key problems in sheet metal forming process, especially with a complex shape. In this paper, the experiments of spring back have been first carried out to study the effect of punch strokes (different bending angles) on the spring-back angle for 6 (mm) thickness of SS400 sheet steel by V-bending process. The experimental results are then validated by finite element analysis (FEA) of ABAQUS software. To simulate spring-back of V-bending, deformed results of V-shape from a dynamic forming simulation in Abaqus/Explicit would be imported into Abaqus/Standard, and then a static analysis will calculate the spring-back of V-bending. Simulation studies have shown that there are different variations in the initial bending angle and the spring-back angle after the removal of the bending force based on isotropic and kinematic hardening models. Therefore, the combined hardening model has been proposed to overcome the mismatch between prediction results and the corresponding experiments. Based on the accuracy of FEM simulation, this study also verifies the effect of parameters such as a thickness of the sheet, punch radius and punch stroke on the spring-back angle in order to select the optimum input parameters by using Taguchi method.
Thermomechanical behavior of graphene nanoplatelets and bamboo micro filler incorporated epoxy hybrid composites
Authors: Gouda Krushna , Bhowmik Sumit , Das Biplab 
Published: January 2020

Abstract
The present study is focused on the development of micro bamboo filler/epoxy hybrid composite with the incorporation of varied weight percentage of graphene nanoplatelet (GNPs). To check the effect of inclusion of dual fillers on the structural x-ray diffraction (XRD), morphological analysis by Scanning electron microscope (SEM) and thermomechanical analysis (TMA) are carried out. The micro bamboo and GNPs filler in the epoxy polymer are incorporated to eradicate the problem associated with natural and synthetic fibers alignment, delamination, and anisotropic property in the thermoset composite materials. Results revealed that with the inclusion of graphene nanoplatelet with bamboo filler in epoxy composite improves the synergetic effect, which in turn increases the tensile, flexural, loss modulus and storage modulus of developed hybrid composite material. SEM analysis confirmed the proper distribution of fillers and their presence from XRD analysis. All fabricated hybrid composite displayed improved thermal conductivity value and a marginal increase in the corrosion rate. The overall result predicts that the improvement is quite better compared to neat or solo bamboo filler based epoxy composite. The improvement is ascribed due to the proper interfacial bonding or cross-link between micro bamboo filler/epoxy polymer with the addition of GNPs. Developed filler based hybrid composite may be utilized for the application of thermal interface material, circuit board, electronic packaging, etc.