bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding social knowledge in the human brain
Authors: Alcalá-López Daniel , Soto David 
Published: August 2020

AbstractThe present functional MRI study addressed how the brain maps different aspects of social information. We focused on two key dimensions of social knowledge: affect and likableness. Thirty participants were presented with audio definitions, half referring to affective (e.g.empathetic) and half to non-affective concepts (e.g.intelligent). Orthogonally, half of the concepts were highly likable (e.g.sincere) and half were socially undesirable (e.g.liar). We used a support vector machine to delineate how both concept dimensions are represented in a set of 9a prioribrain regions defined from previous meta-analyses on semantic and social cognition. We show that average decoding in semantic regions (e.g. lateral temporal lobe, inferior frontal gyrus, and precuneus) outperformed social ROIs (e.g. insula and anterior cingulate), with the lateral temporal lobe containing the highest amount of information about the affect and likableness of social concepts. We also found that the insula had a bias towards affect while the likableness dimension was better represented in anterior cingulate cortex. Our results do not support a modular view of social knowledge representation. They rather indicate that the brain representation of social concepts implicates a distributed network of regions that involves ‘domain-specific’ social cognitive systems, but with a greater dependence on language-semantic processing.
A human-specific structural variation at theZNF558locus controls a gene regulatory network during forebrain development
Authors: Johansson Pia A. , Brattås Per Ludvik , Douse Christopher H. , Hsieh PingHsun , Pontis Julien , Grassi Daniela , Garza Raquel , Jönsson Marie E. , Atacho Diahann A. M. , Pircs Karolina , Eren Feride , Sharma Yogita , Johansson Jenny , Trono Didier , Eichler Evan E. , Jakobsson Johan 
Published: August 2020

AbstractThe human forebrain has expanded in size and complexity compared to that of chimpanzee despite limited changes in protein-coding genes, suggesting that gene regulation is an important driver of brain evolution. Here we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 transposons but has been co-opted to regulate the mitophagy geneSPATA18, supporting a link between mitochondrial homeostasis and cortical expansion. The unusual on-off switch forZNF558expression resides in a downstream variable number tandem repeat (VNTR) that is contracted in humans relative to chimpanzee. Our data reveal the brain-specific co-option of a transposon-controlling KRAB-ZFP and how a human-specific regulatory network is established by acis-acting structural genome variation. This represents a previously undescribed genetic mechanism in the evolution of the human brain.
Spatial scaling of pollen-based alpha and beta diversity within forest and open landscapes of Central Europe
Authors: Abraham Vojtěch , Roleček Jan , Vild Ondřej , Jamrichová Eva , Plesková Zuzana , Werchan Barbora , Svobodová Helena Svitavská , Kuneš Petr 
Published: August 2020

AbstractPollen is an abundant fossil and the most common proxy for plant diversity during the Holocene. Based on datasets in open, forest, and mixed habitats, we used the spatial distribution of floristic diversity to estimate the source area of pollen diversity and identify factors influencing the significance of this relationship.Our study areas are Bohemian-Moravian Highlands and White Carpathians (the Czech Republic and the Slovak Republic).Sampling 60 sites in forest and open habitats in two study regions with contrasting floristic diversity, we calculated taxonomic richness (alpha diversity) and total spatial variance (beta diversity) for pollen and floristic data along two transects, each 1 km long. Following this, we calculated the correlation between floristic and pollen diversity. We also assessed the consistency of the relationship in different habitats. Finally, we regressed local contributions of individual sites to the beta diversity of pollen and floristic data in each of the regions.There was a positive correlation between pollen and floristic richness in both habitats in both regions; open and mixed datasets were significant. The highest correlation (adjusted R2) mostly occurred within the first tens of metres (1.5–70) and then within the first hundreds of metres (250–550). Variances of pollen data significantly correlated with variances of floristic data between 100 and 250 m. Local contributions to beta diversity of pollen and plants significantly correlated in the forest and one of the mixed datasets.Floristic richness at the pollen site and position of the site within the landscape structure determine the sequence of the appearing species in the increasing distance. The number of species sets the source area of pollen richness and dissimilarity of appearing species controls the source area of pollen variance. These findings, linking pollen and floristic diversity, provide an essential stepping-stone for the reconstruction of historic plant diversity.
Reboot: a straightforward approach to identify genes and splicing isoforms associated with cancer patient prognosis
Authors: dos Santos Felipe R. C. , Guardia Gabriela D. A. , dos Santos Filipe F. , Galante Pedro A. F. 
Published: August 2020

AbstractNowadays, the massive amount of data generated by modern sequencing technologies provides an unprecedented opportunity to find genes associated with cancer patient prognosis, connecting basic and translational research. However, treating high dimensionality of gene expression data and integrating it with clinical variables are major challenges to carry out these analyses. Here, we present Reboot, an original and efficient algorithm to find genes and splicing isoforms associated with cancer patient survival, disease progression, or other clinical endpoints. Reboot innovates by using a multivariate strategy with penalized Cox regression (LASSO method) combined with a bootstrap approach, in addition to statistical tests for supporting the findings, which are automatically plotted. Applying Reboot on data from 154 glioblastoma patients, we identified a three-gene signature (IKBIP, OSMR, PODNL1) whose increased derived risk score was significantly associated with worse patients’ prognosis, even in conjunction with other well-established clinical parameters. Similarly, Reboot was able to find a seven-splicing isoforms signature (CENPF-201; MLKL-202; NUP54-201; MCF2L-201; TFDP1-207; BBS1-206; HTT-202) related to worse overall survival in 177 pancreatic adenocarcinoma patients with elevated risk scores after uni- and multivariate analyses. In summary, Reboot is an efficient, intuitive, and straightforward way for finding genes or splicing isoforms (transcripts) signatures relevant to patient prognosis, which can democratize this kind of analysis and shed light on still under-investigated sets of cancer-related genes. Reboot effectively runs on either servers or personal computers and it is freely available atgithub.com/galantelab/reboot.
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease
Authors: Morshed Nader , Lee Meelim , Rodriguez Felicia H. , Lauffenburger Douglas A. , Mastroeni Diego , White Forest 
Published: August 2020

AbstractAlzheimer’s disease (AD) is a form of dementia characterized by amyloid-β plaques and Tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. The signaling networks underlying the pathological changes in AD are poorly characterized at the level phosphoproteome. Using mass spectrometry, we performed a combined analysis of the tyrosine, serine, and threonine phosphoproteome, and proteome of temporal cortex tissue from AD patients and aged matched controls. We identified several co-correlated peptide modules that were associated with varying levels of phospho-Tau, oligodendrocyte, astrocyte, microglia, and neuronal pathologies in AD patients. We observed phosphorylation sites on kinases targeting Tau as well as other novel signaling factors that were correlated with these peptide modules. Finally, we used a data-driven statistical modeling approach to identify individual peptides and co-correlated signaling networks that were predictive of AD histopathologies. Together, these results build a map of pathology-associated phosphorylation signaling events occurring in AD.
Azimuthal-rotation sample holder for molecular orientation analysis
Authors: Harano Takayuki , Takeichi Yasuo , Ohigashi Takuji , Shindo Daisuke , Nemoto Eiji , Wakabayashi Daisuke , Yamashita Shohei , Murao Reiko , Kimura Masao 
Published: August 2020

In this study, an azimuthal-rotation sample holder compatible with scanning transmission X-ray microscopy was developed. This holder exhibits improvement in the accuracy of rotation angles and reduces the displacement of the rotation axes during azimuthal rotation by using a crossed roller bearing. To evaluate the performance of the holder, the authors investigated the dependence of the optical density around the C K-edge absorption of π-orbital-oriented domains in natural spherical graphite on the rotational angle by using linearly horizontally and vertically polarized undulator radiation. Based on the dependence of the optical density ratio between C 1s → π* and 1s → σ* excitation on the polarization angle of the X-rays, the average two-dimensional orientation angle of the π orbital in each position in a natural spherical graphite sample was visualized.
Benchmarks for INGOs’ effective responses during COVID-19 pandemic
Authors: Mahmoud Saleh Firas Izzat , Karia Noorliza 
Published: August 2020

PurposeThis paper aims to formulate COVID-19 benchmarks that international nongovernmental organizations (INGOs) have considered to recover from the sudden stopping of operations swiftly and consequences of COVID-19 pandemic; thus, to move forward toward readiness for both, the unpredictable spreading or disappearing of the virus (case of INGOs operating in Jordan).Design/methodology/approachThis exploratory research has been informed by the broader social constructivism paradigm and the basics of grounded theory method to identify the common themes. Six semistructured interviews have been conducted with INGOs’ leaders. The findings have been categorized, triangulated and prioritized toward the final identification of benchmarks.FindingsSeven COVID-19 benchmarks for INGOs’ effective responses during COVID-19 pandemic have been proposed, comprising of (1) donors’ policies and regulations, (2) needs, expectations and relevancy, (3) coordination, (4) staff management, (5) business continuation plans, (6) balanced short-term and long-term planning and (7) permanent adoption of successful modalities.Social implicationsINGOs play a vital role in the lives of vulnerable people around the world through their international development and aid (IDA) projects. However, the restrictions of movements associated with COVID-19 pandemic drive more burden on these communities and interrupted their access to assistance and support. This paper helps to sustain the crucial support of INGOs to those people who need it.Originality/valueCOVID-19 pandemic has interrupted the implementation of IDA projects, which added further obstacles toward the achievement of quality implementation of these projects. The proposed COVID-19 benchmarks help INGOs to overcome the consequences of pandemic on the near longer-term alike.
The contribution of human resource development managers to organisational branding in the hotel industry in India and South East Asia (ISEA): a dynamic capabilities perspective
Authors: Francois Koukpaki Adebayo Serge , Adams Kweku , Oyedijo Adegboyega 
Published: August 2020

PurposeThis research explores the significant contribution of human resource development (HRD) managers in building organisational brands in the hotel industry through the lenses of dynamic capabilities for sustaining competitiveness.Design/methodology/approachUsing a qualitative case study design, this study deployed a semi-structured interview research method. It used a purposive sample of 20 HRD managers across twenty different hotels in India and South East Asia (ISEA) to explore their contribution to organisational brands. The data was analysed using thematic analysis.FindingsThe findings show the significance of HRD in building organisational brands. From a dynamic capabilities perspective, it was found that HRD has an impact on fostering brand awareness culture; HRD functional branding enhances the creation and sustaining of quality service culture; functional branding of HRD helps differentiate the brand and quality service, for product development and innovation by linking talent development and growth of key competencies and capabilities; brand training and behavioural training directly influence the right behaviour knowledge and effective communication that is translated into the enhancement of guest experience; and finally, organisational branding through branding culture and employer branding creates organisational wealth.Originality/valueThe authors propose a new conceptual framework for the branding of the Heroes to reclaim the HRD's splendour in the realm of other functions in the hotel industry in ISEA contexts. While the authors do not claim an external generalisability, we believe that an analytical application of this framework could be relevant in similar environments. The study also claims that HRD practitioners could use parallel literature repertoires from brand management discourse to value their strategic contributions in building and maintaining their reputational position at the board level. Practical implications and further research are discussed.
The transformational potential of Latin American retail experiences
Authors: Gardiazabal Pilar , Bianchi Constanza , Saleh M. Abu 
Published: August 2020

PurposeThe purpose of this paper is to investigate if retail services have a transformative potential to improve the well-being of customers in a Latin American market. Transformative studies have been conducted mostly in developed countries, and consumer well-being in a Latin American supermarket context has not been addressed previously. Specifically, this study aims to understand if customer satisfaction with a supermarket experience in Chile leads to positive customer well-being. Additionally, it is examined if customer well-being influences firm outcomes, such as customer loyalty, word-of-mouth (WOM) communication or retailer equity.Design/methodology/approachA conceptual model was developed, and data was collected through an online survey from 866 customers of a large supermarket chain in Chile. Hypotheses were tested with structural equation modeling.FindingsThe findings of this study support all the hypotheses of the model and confirm that customer satisfaction has direct and indirect effects on customer loyalty and other firm outcomes through customer well-being.Research limitations/implicationsThis research is among the few studies in the academic literature that considers retail experience and well-being outcomes for supermarket customers in a Latin American context. Limitations derive from the cross-sectional nature of this study.Practical implicationsThere are implications from this study contributing to the literature on customer retail experience, in terms of the potential to transform supermarket shopping in a Latin American country. This is particularly relevant in Latin America as the extent to which for-profit organizations acknowledge their relevancy of the individuals’ well-being is still at its infancy.Social implicationsThis research provides empirical support to the importance of not only looking at traditional measures such as WOM, equity and loyalty but looking into the impact services have for customers’ life and well-being.Originality/valueThis study contributes to the services literature and addresses a gap in it by exploring the transformative potential of supermarket shopping on customer well-being and in turn the role of customer well-being in retail firm outcomes. The findings also contribute in considering Chile, a Latin American context that has been overlooked in the transformative services studies. This provides managerial implications for domestic and global companies that offer grocery retailing for consumers in this region.
Anticorrosive paint with a modified zeolite as functional pigment for SAE 1010 steel protection
Authors: D'Alessandro Oriana , Byrne Christian Eduardo , Selmi Gonzalo , Deyá Cecilia 
Published: August 2020

Purpose
This paper aims to formulate and prepare a series of alkyd paints with new anticorrosive pigments, eco-friendly to the environment, based on a natural zeolitic rock modified by ion exchange to incorporate passivating cations.

Design/methodology/approach
The electrochemical characterization of the painted steel was carried out by conductivity measurements, linear polarization tests, measurements of the corrosion potential and electrochemical noise measurements. Besides, accelerated tests in standard environmental chambers were also carried out.

Findings
The results show that clinoptilolite–mordenite-based pigments incorporated in the paint provide acceptable anticorrosive properties, taking into account their low environmental impact and the use of a natural resource of low cost. The inhibitory efficiency of ZLa is higher than 80% and of ZPr is close to 70%. The electrochemical assays of the coated panels with the alkyd paints ZLa and ZPr shows similar behavior.

Research limitations/implications
In this work, good results were obtained with an alkyd resin, but other resins could be tested. Paints could also be formulated with modified zeolites as a complement to others traditional anticorrosive pigments.

Practical implications
These paints could be used for the protection of metal structures in low corrosive environments.

Originality/value
There are not many published works using zeolites as anticorrosive pigments.
Examining the role of dialogic communication and trust in donation-based crowdfunding tasks using information quality perspective
Authors: Behl Abhishek , Dutta Pankaj , Sheorey Pratima , Singh Rajesh Kumar 
Published: August 2020

PurposeThe study explores the role of dialogic public communication and information quality (IQ) in evaluating the operational performance of donation-based crowdfunding (DBC) tasks. These tasks are primarily used to support disaster relief operations. The authors also test the influence of cognitive trust and swift trust as moderating variables in explaining the relationship between both IQ and dialogic communication with operational performance.Design/methodology/approachThe authors used a primary survey to test the hypotheses. A total of 203 responses were collected from multiple crowdfunding platforms. The authors used archival data from task creators on donation-based crowdfunding platforms, and a structured questionnaire is also used to collect responses. Data are analyzed using Warp PLS 6.0. Warp PLS 6.0 works on the principle of partial least square (PLS) structured equation modeling (SEM) and has been used widely to test path analytical models.FindingsThe authors found out that the operational performance is explained significantly by the quality of information and its association with dialogic public communication. The results support the arguments offered by dialogic public communication theory and trust transfer theory in assessing the operational success of DBC. The study also confirms that cognitive trust positively moderates the relationship between IQ and organizational public dialogic communication and operational performance. It is also revealed that the duration of the DBC task has no significant control over dialogic public communication.Practical implicationsThe study lays practical foundations for task creators on DBC platforms and website designers as it sets the importance of both IQ and dialogic communication channels. The communication made by the task creator and/or the DBC platforms with the donors and potential donors in the form of timely and appropriate information forms the key to the success of any DBC task. The study also helps task creators choose a suitable platform to improve performance.Originality/valueThe authors propose a unique framework by integrating two theoretical perspectives: dialogic public relation theory and trust transfer theory in understanding the operational performance of donation-based crowdfunding tasks. The authors address DBC tasks catering to disaster relief operations by collecting responses from task creators on DBC platforms. The study uniquely positions itself in the area of information and communication.
Achieving margin clearance following oncoplastic breast surgery in comparison with simple wide local excision: a three‐dimensional specimen assessment
Authors: Garreffa Emanuele , Kankam Hadyn K. N. , Bali Radhika , Duckworth Adam , Jimenez Linan Mercedes , Mahler Araujo Betania , Moyle Penelope , Wright Penny , Provenzano Elena , Agrawal Amit 
Published: August 2020

AbstractBackgroundPre‐operative breast tumour radial dimensions often determine the choice between simple wide local excision (WLE) and oncoplastic breast surgery (OBS). We reviewed the three‐dimensional interplay between tumour and surgical specimen dimensions in the two cohorts.MethodsDemographic, tumour and treatment data were collected for all patients undergoing OBS by a single surgeon and compared with a randomly selected cohort of WLE patients treated. The relationship between tumour and specimen medio‐lateral, supero‐inferior and antero‐posterior dimensions were explored in both groups. Subgroup analyses were performed in the OBS cohort (parenchymal displacement versus replacement).ResultsWe identified 60 OBS patients (63 breasts), comparing them with 60 WLE patients. Pre‐operative tumour estimated size was significantly larger in the OBS cohort and concordant with macroscopic tumour radial dimensions and final microscopic tumour size. Surgical specimen weight was more than 3.5 times higher in the OBS group and its radial dimensions were almost double. No significant difference was observed for the antero‐posterior dimensions. The rate of margin re‐excisions and completion mastectomies were lower in the OBS cohort. WLE patients with positive margins had a lower tumour‐to‐specimen ratio, whereas, the requirement for further surgery in the OBS cohort was associated with larger tumour dimensions.ConclusionDespite larger tumour dimensions, OBS is not inferior to WLE in providing clear surgical margins. Our analysis of the three‐dimensional spatial relationship between cancer and surgical specimen, although not completely conclusive, can be helpful in the selection of the most appropriate surgical approach for every patient.
Macroprudential Policy on an Uneven Playing Field: Supranational Regulation and Domestic Politics in the EU's Dependent Market Economies
Authors: Piroska Dóra , Gorelkina Yuliya , Johnson Juliet 
Published: August 2020

AbstractCentral bankers and financial regulators in East Central Europe and the Balkans regularly employed macroprudential policy before the global financial crisis and continue to be among its most active proponents in the European Union. We draw upon the Dependent Market Economy framework to explore how the EU's five DMEs – the Czech Republic, Hungary, Poland, Romania, and Slovakia – have used macroprudential policy to manage the uneven distributional effects of financial globalization and European integration. We contend that while structural and EU‐specific institutional factors define the available policy space, policy choices within that space depend upon how domestic actors translate macroprudential policies into their local contexts. Overall, our analysis highlights the social impact and challenges to European integration of heavy DME reliance on macroprudential policy making, especially when motivated by domestic financial nationalism.