bluuebunny/crossref_metadata_2025_split huggingface dataset:
FOBI: an ontology to represent food intake data and associate it with metabolomic data
Authors: Castellano-Escuder Pol , González-Domínguez Raúl , Wishart David S , Andrés-Lacueva Cristina , Sánchez-Pla Alex 
Published: June 2020

AbstractNutrition research can be conducted by using two complementary approaches: (i) traditional self-reporting methods or (ii) via metabolomics techniques to analyze food intake biomarkers in biofluids. However, the complexity and heterogeneity of these two very different types of data often hinder their analysis and integration. To manage this challenge, we have developed a novel ontology that describes food and their associated metabolite entities in a hierarchical way. This ontology uses a formal naming system, category definitions, properties and relations between both types of data. The ontology presented is called FOBI (Food-Biomarker Ontology) and it is composed of two interconnected sub-ontologies. One is a ’Food Ontology’ consisting of raw foods and ‘multi-component foods’ while the second is a ‘Biomarker Ontology’ containing food intake biomarkers classified by their chemical classes. These two sub-ontologies are conceptually independent but interconnected by different properties. This allows data and information regarding foods and food biomarkers to be visualized in a bidirectional way, going from metabolomics to nutritional data or vice versa. Potential applications of this ontology include the annotation of foods and biomarkers using a well-defined and consistent nomenclature, the standardized reporting of metabolomics workflows (e.g. metabolite identification, experimental design) or the application of different enrichment analysis approaches to analyze nutrimetabolomic data. Availability: FOBI is freely available in both OWL (Web Ontology Language) and OBO (Open Biomedical Ontologies) formats at the project’s Github repository (https://github.com/pcastellanoescuder/FoodBiomarkerOntology) and FOBI visualization tool is available in https://polcastellano.shinyapps.io/FOBI_Visualization_Tool/.
Delayed patch repair of a ruptured mitral subvalvular pseudoaneurysm caused by infective endocarditis: a case report
Authors: Hohri Yu , Yamazaki Sachiko , Numata Satoshi , Yaku Hitoshi 
Published: June 2020

Abstract

Background
Ruptured subvalvular pseudoaneurysm is a rare but significantly fatal complication of infective endocarditis. We report a successful surgical case of ruptured subvalvular pseudoaneurysm with infective endocarditis.

Case summary
A 46-year-old man presenting with high fever was admitted to a local hospital. Physical examination revealed small erythema and petechiae on his lower limbs. Transthoracic echocardiogram did not show any visible vegetation and valvular disease; however, magnetic resonance imaging (MRI) showed multiple acute cerebral infractions, and methicillin-susceptible Staphylococcus aureus was detected in the blood culture. Infective endocarditis was suspected, and an antibacterial medication was initiated. Twelve days later, he suffered from a sudden cardiogenic shock due to cardiac tamponade. Bloody pericardial effusion (1600 mL) was drained, and his condition improved substantially. Transoesophageal echocardiography after pericardial drainage revealed severe mitral regurgitation and a subvalvular aneurysm at the posteromedial side of the mitral annulus; these were not detected at the time of admission. He was transferred to our hospital for surgery; however, since fresh cerebral bleeding was observed in MRI, the surgery was delayed. Three weeks later, after confirming that the blood culture was negative for any growth, patch repair of the subvalvular pseudoaneurysm and mitral valve repair were performed. Post-operatively, no complication or arrhythmia was observed; he was discharged 25 days later.

Discussion
We report a rare case of successful delayed surgery for a ruptured subvalvular pseudoaneurysm at the posteromedial side of the mitral annulus, which presented complications for infective endocarditis by S. aureus.
Longitudinal Dyadic Effects of Aging Self-Perceptions on Health
Authors: Cohn-Schwartz Ella , Segel-Karpas Dikla , Ayalon Liat 
Published: June 2020

Abstract

Objectives
Adults’ perceptions of aging are known to affect their mental and physical health. However, not much is known about how perceptions of aging within the couple-unit affect each member of the unit. Therefore, the current study explores the effects of husbands’ and wives’ self-perceptions of aging (SPA) on each other’s physical and mental health, both directly and indirectly, through impacting each other’s SPA.

Method
The study used data from the Health and Retirement Study, focusing on couples aged 50 and older. Self-rated health and Center for Epidemiological Studies Depression scale (CES-D) were used as indicators of physical and mental health. SPA was measured using the “Attitudes toward aging” subscale of the “Philadelphia Geriatric Center Morale Scale.” An actor–partner interdependence mediation model was used to examine the effects of the 2008 SPA of couples on each other’s 2012 SPA and 2016 health.

Results
The SPA of both husbands and wives was associated with their own future mental and physical health in 2016, but not with that of their partner. However, their SPA was associated with their partner’s health indirectly, by influencing the SPA of the partner. That is, the SPA of both husbands and wives in 2008 impacted their partner’s SPA in 2012, which was subsequently related to that partner’s mental and physical health in 2016.

Discussion
Older couples can influence each other’s health indirectly, by affecting each other’s SPA. This indicates that adults’ SPA are interconnected, and thus, the entire couple-unit should be targeted to enhance positive SPA.
Gender Authorship in the Field of Clinical Chemistry
Authors: Annesley Thomas M 
Published: June 2020

Abstract

Background
Gender underrepresentation has long existed in the science, technology, engineering, and mathematics fields. While there are upward trends in many areas of the life and health sciences, some disciplines are underrepresented in female author numbers, including first and corresponding authors. This study evaluated the participation by women as authors in the field of clinical chemistry.

Methods
Clinical Chemistry and The Journal of Applied Laboratory Medicine were selected for data collection. Data were classified into four categories: total number of authors for each article, number of female authors for each article, whether the first author was female, and whether the corresponding author was female. From these data, the percentages of female authors, articles with female first authors, articles with female corresponding authors, and articles where a female was either first or corresponding author were calculated.

Results
Both journals had ≥40% total female authorship, ≥45% female first author, and 64% female first or corresponding author. The 40% female author number matched the percentage of female doctoral degree, board certified clinical chemists, and the 39% female PhDs and MDs in academic clinical pathology departments. Compared with a selected group of science or medicine journals and gender reports, Clinical Chemistry and The Journal of Applied Laboratory Medicine exceeded most journals and gender reports in female total authorship, first author, and corresponding author.

Conclusions
Women are well represented as authors in these two clinical chemistry journals. Both journals compare favorably against other scientific/medical journals. Female authorship in these two journals also parallels gender composition of the field of clinical chemistry.
COVID-19 TestNorm: A tool to normalize COVID-19 testing names to LOINC codes
Authors: Dong Xiao , Li Jianfu , Soysal Ekin , Bian Jiang , DuVall Scott L , Hanchrow Elizabeth , Liu Hongfang , Lynch Kristine E , Matheny Michael , Natarajan Karthik , Ohno-Machado Lucila , Pakhomov Serguei , Reeves Ruth Madeleine , Sitapati Amy M , Abhyankar Swapna , Cullen Theresa , Deckard Jami , Jiang Xiaoqian , Murphy Robert , Xu Hua 
Published: June 2020

AbstractLarge observational data networks that leverage routine clinical practice data in electronic health records (EHRs) are critical resources for research on coronavirus disease 2019 (COVID-19). Data normalization is a key challenge for the secondary use of EHRs for COVID-19 research across institutions. In this study, we addressed the challenge of automating the normalization of COVID-19 diagnostic tests, which are critical data elements, but for which controlled terminology terms were published after clinical implementation. We developed a simple but effective rule-based tool called COVID-19 TestNorm to automatically normalize local COVID-19 testing names to standard LOINC (Logical Observation Identifiers Names and Codes) codes. COVID-19 TestNorm was developed and evaluated using 568 test names collected from 8 healthcare systems. Our results show that it could achieve an accuracy of 97.4% on an independent test set. COVID-19 TestNorm is available as an open-source package for developers and as an online Web application for end users (https://clamp.uth.edu/covid/loinc.php). We believe that it will be a useful tool to support secondary use of EHRs for research on COVID-19.
Random and Directed Movement by Warren Root Collar Weevils (Coleoptera: Curculionidae), Relative to Size and Distance of Host Lodgepole Pine Trees
Authors: Balogh Sharleen L , Björklund Niklas , Huber Dezene P W , Lindgren B Staffan 
Published: June 2020

AbstractHylobius warreni Wood (Coleoptera: Curculionidae) is a pest of conifers, especially lodgepole pine (Pinus contorta var. latifolia Douglas ex Loudon) (Pinales: Pinaceae) in the Interior of British Columbia. The larvae feed on the roots and root collars and cause girdling damage, resulting in mortality or growth reductions. Previous research has suggested the adult weevils locate potential host trees by using random movements and vision, but likely not chemosensory cues. The purpose of this study is to determine if adult H. warreni respond to particular tree characteristics versus encounter potential hosts at random. Study A was a capture–mark–recapture experiment where weevils were captured on mature pine trees, while Study B was a tracking experiment within a young pine plantation. Weevils showed a preference for larger trees, and for trees that were closer to the weevil’s last known location. In Study A, weevils also avoided climbing trees in poor health, while in Study B, the weevils’ preference for taller trees increased as their distance from the weevil increased, as well as when taller trees were closer to other trees. Movement rates were similar to those observed in previous studies, were positively correlated with the average spacing of trees, and declined with time after release. This confirms previous findings that H. warreni may locate host trees by both vision and random movements, and that their movements are determined primarily by the size and distribution of potential host trees within their habitat.
Cardiology consultation in oncology practice: a 5-year survey
Authors: Tajiri Kazuko , Sekine Ikuo , Naito Hiroyuki , Murata Momoko , Li Siqi , Inoue Keiko , Sasamura Rumi , Nakajima Hideki , Iida Noriko , Nagashio Kenji , Honda Junya , Murakoshi Nobuyuki , Ishizu Tomoko , Ieda Masaki 
Published: June 2020

Abstract

Objective
Onco-cardiology services are expanding rapidly in Japan. To provide a better service, it is important to consider the needs of oncologists. However, little is known regarding specific needs for which oncologists should consult cardiologists to manage cardiovascular problems of their patients. We analysed cardiology consultations sought by oncologists to evaluate the role of cardiologists in cancer treatment.

Method
We retrospectively investigated consecutive 2064 cardiology consultations of cancer patients in the University of Tsukuba Hospital, Tsukuba, Japan, between January 2014 and December 2018.

Results
The most common timing of cardiology consultation was before the commencement of cancer treatment (n = 1355; 65.7%), followed by after the commencement of cancer treatment (n = 686; 33.2%). Among the 361 consultations before the administration of anticancer drugs, 235 (65.1%) were for anthracycline-based regimens. There were 506 (24.5%) consultations for the management of cardiovascular emergencies developing after the commencement of cancer treatment; venous thromboembolism was the most frequent (n = 125; 24.7%), followed by atrial fibrillation (n = 110; 21.7%) and heart failure (n = 74; 14.6%). There were marked differences in the types of cardiovascular emergencies depending on the type of cancer.

Conclusions
This survey revealed the various cardiovascular problems for which oncologists sought interventions by cardiologists. A multidisciplinary approach in an onco-cardiology service is essential to achieve optimal long-term outcomes.
Physical characterization of 2020 AV2, the first known asteroid orbiting inside Venus orbit
Authors: Popescu M , de León J , de la Fuente Marcos C , Vaduvescu O , de la Fuente Marcos R , Licandro J , Pinter V , Tatsumi E , Zamora O , Fariña C , Curelaru L 
Published: June 2020

ABSTRACT
The first known asteroid with the orbit inside that of Venus is 2020 AV2. This may be the largest member of a new population of small bodies with the aphelion smaller than 0.718 au, called Vatiras. The surface of 2020 AV2 is being constantly modified by the high temperature, by the strong solar wind irradiation that characterizes the innermost region of the Solar system, and by high-energy micrometeorite impacts. The study of its physical properties represents an extreme test-case for the science of near-Earth asteroids. Here, we report spectroscopic observations of 2020 AV2 in the 0.5–1.5-μm wavelength interval. These were performed with the Nordic Optical Telescope and the William Herschel Telescope. Based on the obtained spectra, we classify 2020 AV2 as a Sa-type asteroid. We estimate the diameter of this Vatira to be $1.50_{-0.65}^{+1.10}$ km by considering the average albedo of A-type and S-complex asteroids ($p_V=0.23_{-0.08}^{+0.11}$), and the absolute magnitude (H = 16.40 ± 0.78 mag). The wide spectral band around 1 μm shows the signature of an olivine-rich composition. The estimated band centre BIC = 1.08 ± 0.02 μm corresponds to a ferroan olivine mineralogy similar to that of brachinite meteorites.
A MeerKAT survey of nearby nova-like cataclysmic variables
Authors: Hewitt D M , Pretorius M L , Woudt P A , Tremou E , Miller-Jones J C A , Knigge C , Castro Segura N , Williams D R A , Fender R P , Armstrong R , Groot P , Heywood I , Horesh A , van der Horst A J , Koerding E , McBride V A , Mooley K P , Rowlinson A , Stappers B , Wijers R A M J 
Published: June 2020

ABSTRACT
We present the results of MeerKAT radio observations of 11 nearby nova-like cataclysmic variables (CVs). We have detected radio emission from IM Eri, RW Sex, V3885 Sgr, and V603 Aql. While RW Sex, V3885 Sgr, and V603 Aql had been previously detected, this is the first reported radio detection of IM Eri. Our observations have doubled the sample of non-magnetic CVs with sensitive radio data. We observe that at our radio detection limits, a specific optical luminosity ${\gtrsim}2.2\times 10^{18}\,$ erg s−1 Hz−1 (corresponding to MV ≲ 6.0) is required to produce a radio detection. We also observe that the X-ray and radio luminosities of our detected nova-like CVs are on an extension of the $L_X\propto L_R^{\sim 0.7}$ power law originally proposed for non-pulsating neutron star low-mass X-ray binaries. We find no other correlations between the radio emission and emission in other wavebands or any other system parameters for the existing sample of radio-detected non-magnetic CVs. We measure in-band (0.9–1.7 GHz) radio spectral indices that are consistent with reports from earlier work. Finally, we constructed broad spectral energy distributions for our sample from published multiwavelength data, and use them to place constraints on the mass transfer rates of these systems.
Pervasive Selection against MicroRNA Target Sites in Human Populations
Authors: Hatlen Andrea , Marco Antonio 
Published: June 2020

AbstractMicroRNA target sites are often conserved during evolution and purifying selection to maintain such sites is expected. On the other hand, comparative analyses identified a paucity of microRNA target sites in coexpressed transcripts, and novel target sites can potentially be deleterious. We proposed that selection against novel target sites pervasive. The analysis of derived allele frequencies revealed that, when the derived allele is a target site, the proportion of nontarget sites is higher than expected, particularly for highly expressed microRNAs. Thus, new alleles generating novel microRNA target sites can be deleterious and selected against. When we analyzed ancestral target sites, the derived (nontarget) allele frequency does not show statistical support for microRNA target allele conservation. We investigated the joint effects of microRNA conservation and expression and found that selection against microRNA target sites depends mostly on the expression level of the microRNA. We identified microRNA target sites with relatively high levels of population differentiation. However, when we analyze separately target sites in which the target allele is ancestral to the population, the proportion of single-nucleotide polymorphisms with high Fst significantly increases. These findings support that population differentiation is more likely in target sites that are lost than in the gain of new target sites. Our results indicate that selection against novel microRNA target sites is prevalent and, although individual sites may have a weak selective pressure, the overall effect across untranslated regions is not negligible and should be accounted when studying the evolution of genomic sequences.
Gender, Power and Privilege in the Parliamentary Workplace
Authors: Erikson Josefina , Verge Tània 
Published: June 2020

AbstractThis introduction to the Special Section ‘Parliaments as workplaces: gendered approaches to the study of legislatures’ makes the case for revisiting the conditions under which male and female Members of Parliament (MPs) and staff carry out their parliamentary duties, thereby furthering the understanding of parliaments’ inner workings. It shows that adopting a workplace perspective grounded on feminist institutionalist analyses and gender organisational studies opens up new avenues for studying parliaments and the outcomes of political representation. The article then outlines how contributors to this Special Section deal with various aspects of the parliamentary workplace and concludes by highlighting the wider implications of this perspective for examining crucial questions of the parliamentary studies research agenda.
On the First Hochschild Cohomology of Cocommutative Hopf Algebras of Finite Representation Type
Authors: Chang Hao 
Published: June 2020

Abstract
Let $\mathscr{B}_0({\mathcal{G}})\subseteq k\,{\mathcal{G}}$ be the principal block algebra of the group algebra $k\,{\mathcal{G}}$ of an infinitesimal group scheme ${\mathcal{G}}$ over an algebraically closed field $k$ of characteristic ${\operatorname{char}}(k)=:p\geq 3$. We calculate the restricted Lie algebra structure of the first Hochschild cohomology ${\mathcal{L}}:={\operatorname{H}}^1(\mathscr{B}_0({\mathcal{G}}),\mathscr{B}_0({\mathcal{G}}))$ whenever $\mathscr{B}_0({\mathcal{G}})$ has finite representation type. As a consequence, we prove that the complexity of the trivial ${\mathcal{G}}$-module $k$ coincides with the maximal toral rank of ${\mathcal{L}}$.
COMPARISON OF EXPERIMENTAL AND NUMERICAL METHODS OF PATIENT DOSE ESTIMATIONS IN CT USING ANTHROPOMORPHIC MODELS
Authors: Fehrmann M L , Schegerer A , Werncke T , Schlattl H 
Published: June 2020

AbstractThe common methods for patient dose estimations in computed tomography (CT) are thermoluminescence dosemeter (TLD) measurements or the usage of software packages based on Monte Carlo simulations like CT-Expo or the newer CTVoxDos, which uses the ICRP Reference Adult Male (ICRP 110). Organ (OD) and effective doses of a CT protocol of the upper abdomen are compared. Compared to CTVoxDos, ODs inferred by TLD measurement using an anthropomorphic phantom differ by $\mathbf{(19\pm 16)\,\%}$ inside the primary radiation field, $\mathbf{(14\pm 2)\,\%}$ for partially primary irradiated organs and $\mathbf{(34\pm 38)\,\%}$ in the scattered radiation field. ODs estimated by CT-Expo show a mean deviation of $\mathbf{(16\pm 9)\,\%}$ (primary irradiated) and $\mathbf{(28\pm 31)\,\%}$ (scatter irradiated) from ODs estimated by CTVoxDos.
Demand for Information, Uncertainty, and the Response of U.S. Treasury Securities to News
Authors: Benamar Hedi , Foucault Thierry , Vega Clara 
Published: June 2020

Abstract
We use clickstream data to show that investors’ demand for information about macroeconomic factors affecting the path of future interest rates is a measure of their uncertainty about this path. In particular, an increase in information demand ahead of influential economic announcements affecting investors’ beliefs about future interest rates predicts a stronger reaction of U.S. Treasury note yields to these announcements, as it should if information demand positively covaries with uncertainty. This relationship does not vanish after using standard measures of uncertainty as predictors, suggesting that clickstream data contain unique information about investors’ uncertainty.
Hyperactive ACC-MDT Pathway Suppresses Prepulse Inhibition in Mice
Authors: Kim Yangsik , Noh Young Woo , Kim Kyungdeok , Kim Eunjoon 
Published: June 2020

Abstract
Altered prepulse inhibition (PPI) is an endophenotype associated with multiple brain disorders, including schizophrenia. Circuit mechanisms that regulate PPI have been suggested, but none has been demonstrated through direct manipulations. IRSp53 is an abundant excitatory postsynaptic scaffold implicated in schizophrenia, autism spectrum disorders, and attention-deficit/hyperactivity disorder. We found that mice lacking IRSp53 in cortical excitatory neurons display decreased PPI. IRSp53-mutant layer 6 cortical neurons in the anterior cingulate cortex (ACC) displayed decreased excitatory synaptic input but markedly increased neuronal excitability, which was associated with excessive excitatory synaptic input in downstream mediodorsal thalamic (MDT) neurons. Importantly, chemogenetic inhibition of mutant neurons projecting to MDT normalized the decreased PPI and increased excitatory synaptic input onto MDT neurons. In addition, chemogenetic activation of MDT-projecting layer 6 neurons in the ACC decreased PPI in wild-type mice. These results suggest that the hyperactive ACC-MDT pathway suppresses PPI in wild-type and IRSp53-mutant mice.