bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isotopic reconstruction of human diet in the Ji'erzankale site, Xinjiang Uyghur Autonomous Region, China
Authors: Guo Yi , Lou Jia , Xie Shiyu , Wu Xinhua , Fuller Benjamin T. 
Published: October 2019

AbstractThe Ji'erzankale Necropolis (吉尔赞喀勒墓地) is located on the Pamir Plateau in the Xinjiang Uyghur Autonomous Region of China. Composed of numerous stone circle graves and directly radiocarbon dated to the Iron Age (ca. 2400–2600 years cal BP), this site is unique in that numerous lines of archaeological evidence suggest that those interred here were followers of the Zoroastrian religion. Here, we present carbon (δ13C) and nitrogen (δ15N) stable isotope ratio measurements of seeds (Nitraria pamirica, n = 7), animals (n = 14), and humans (n = 24) to reconstruct ancient diet and lifeways at the Ji'erzankale Necropolis. The results of the N. pamirica reflect the natural C3 vegetation and arid environment of this region. The δ13C (mean ± SD = –18.6 ± 0.8‰) and δ15N (mean ± SD = +8.1 ± 1.6‰) results of the animals (13 sheep and 1 hare) display a mostly C3 terrestrial diet with variable levels of protein consumption. Adult humans (n = 19) have δ13C (mean ± SD = –17.9 ± 0.2‰) and δ15N (mean ± SD = +13.1 ± 0.3‰) results that tightly cluster above the sheep by approximately +5‰. This is evidence that the diet of this population was relatively homogenous and mainly based on sheep and/or their secondary products and did not have a large input of C4 crops such as foxtail (Setaria italica) or common millet (Panicum miliaceum).
Impact of the parent‐child relationship on psychological and social resilience in pediatric cancer patients
Authors: Tillery Rachel , Willard Victoria W. , Howard Sharp Katianne M. , Klages Kimberly L. , Long Alanna M. , Phipps Sean 
Published: October 2019

AbstractObjectivesThe primary objective of this research was to examine patterns of parent‐child relationship functioning among pediatric cancer survivors and their caregivers across a variety of relationship indicators (ie, Involvement, Attachment, Communication, Parenting Confidence, and Relational Frustration), and evaluate how these factors relate to psychosocial outcomes in survivors.MethodsYoung survivors aged 10 to 18 and their caregivers (N = 165) completed measures related to posttraumatic stress and general distress. Caregivers also completed assessments of parent‐child relationship functioning, and survivors completed assessments of social functioning. Latent profile analysis was performed to identify patterns of relationship functioning. Medical, demographic, and parent functioning variables were examined as predictors, and youth's psychological and social functioning were examined as outcomes.ResultsA three‐class solution was the best fit to the data. The struggling parent‐child relationship profile (15%) evidenced below average levels of parent‐child relationship functioning across several domains. The normative parent‐child relationship (60%), was characterized by average levels of parent‐child relationship functioning across all domains. Finally, the high‐involved parent‐child relationship profile (25%) demonstrated above average levels of parent‐child relationship functioning in involved activities, communication, and attachment and normative levels of functioning across all other domains. Medical and parent functioning factors predicted profile membership. In turn, profile membership was associated with survivor psychological and social outcomes.ConclusionFindings document the importance of extending existing research to examine patterns of parent‐child relationship functioning, which may serve as a clinically relevant target to improve psychological and social outcomes in young survivors of childhood cancer.
The role of masculinities in psychological and emotional help seeking by men with prostate cancer
Authors: Goodwin Belinda C. , Ralph Nicholas , Ireland Michael J. , Hyde Melissa K. , Oliffe John L. , Dunn Jeff , Chambers Suzanne 
Published: October 2019

AbstractObjectiveTo assess the impact of demographic characteristics and masculinities on seeking support for psychosocial care needs in men with prostate cancer.MethodsProstate cancer survivors (n = 225) completed mail‐out surveys measuring psychological care needs, masculinities, and psychological and emotional help‐seeking intention and behaviour at 6‐ and 12‐month follow‐ups.ResultsOlder age was associated with seeking help from a general practitioner (GP), χ2 (1,225) = 4.72, P = .03, and being born overseas was associated with seeking peer support (1,225) = 7.13, P = .01. Men with higher levels of optimistic action who reported moderate to high unmet psychological need were less likely to seek help for psychological and emotional concerns at 6‐ (odds ratio [OR] = 0.06, confidence interval [CI], 0.01‐0.46) and 12‐month (OR = 0.13, CI, 0.26‐0.65) follow‐ups.ConclusionsOptimistic action may explain why some men with prostate cancer fail to seek help for their psychological care needs. Clinicians should be aware that men with chronic illness who appear to approach challenges with optimistic action may in fact be less likely to seek psychological help when needed.
Validation of a biopsychosocial distress screening tool, “You, Your Family and COH Are a Team”
Authors: Wong F. Lennie , Stiller Tracey , Obenchain Richard , David Cristina , Patel Sunita K. , Xie Bin , Loscalzo Matthew , Clark Karen 
Published: October 2019

AbstractObjectiveWe examined the psychometric properties of a biopsychosocial screening tool “You, Your Family and City of Hope are a Team” implemented via touchpad technology (YYFcore03) at a cancer center in newly diagnosed patients and patients on active treatment, with the primary objective to evaluate concurrent validity with screening criterion measures of depression and anxiety.MethodsYYFcore03, Patient Health Questionnaire [PHQ‐9], and Generalized Anxiety Disorder [GAD‐7] were administered to 608 patients in out‐patient clinics. A subset of 158 patients responding a second time to YYFcore03 at a subsequent visit were included for assessing reliability. Exploratory factor analysis followed by confirmatory factor analysis were conducted to identify underlying factors. The identified factor of psychological distress (PD) was then correlated with PHQ‐9 and GAD‐7 for concurrent validity and to estimate sensitivity‐specificity. Demographic and clinical variables associated with the PD score were identified. Test‐retest reliability of PD score was examined.ResultsFactor analysis suggested three factors, including PD. Correlations between PD score and PHQ‐9 and GAD‐7 were 0.63 and 0.67, respectively. Treating PHQ‐9 and GAD‐7 as criterion measures, PD score had a sensitivity of 0.77 for identifying depression and 0.86 for identifying anxiety. Younger age, lower household income, and cancer (vs noncancer) diagnosis were independently associated with worse PD score. Omega total for composite reliability was 0.88; intraclass correlation was 0.78.ConclusionsThe YYFcore03 administered via touchpad is a valid instrument for identifying PD in newly diagnosed patients and patients undergoing active treatment.
Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth
Authors: Carbonetti Gregory , Converso Cynthia , Clement Timothy , Wang Changwei , Trotman Lloyd C , Ojima Iwao , Kaczocha Martin 
Published: October 2019

AbstractBackgroundProstate cancer (PCa) remains the second leading cause of cancer‐related death among men. Taxanes, such as docetaxel and cabazitaxel are utilized in standard treatment regimens for chemotherapy naïve castration‐resistant PCa. However, tumors often develop resistance to taxane chemotherapeutics, highlighting a need to identify additional therapeutic targets. Fatty acid‐binding protein 5 (FABP5) is an intracellular lipid carrier whose expression is upregulated in metastatic PCa and increases cell growth, invasion, and tumor formation. Here, we assessed whether FABP5 inhibitors synergize with semi‐synthetic taxanes to induce cytotoxicity in vitro and attenuate tumor growth in vivo.MethodsPC3, DU‐145, and 22Rv1 PCa cells were incubated with FABP5 inhibitors Stony Brook fatty acid‐binding protein inhibitor 102 (SBFI‐102) or SBFI‐103 in the presence or absence of docetaxel or cabazitaxel, and cytotoxicity was evaluated using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5 diphenyl tetrazolium bromide assay. Cytotoxicity of SBFI‐102 and SBFI‐103 was also evaluated in noncancerous cells. For the in vivo studies, PC3 cells were subcutaneously implanted into BALB/c nude mice, which were subsequently treated with FABP5 inhibitors, docetaxel, or a combination of both.ResultsSBFI‐102 and SBFI‐103 produced cytotoxicity in the PCa cells. Coincubation of the PCa cells with FABP5 inhibitors and docetaxel or cabazitaxel produced synergistic cytotoxic effects in vitro. Treatment of mice with FABP5 inhibitors reduced tumor growth and a combination of FABP5 inhibitors with a submaximal dose of docetaxel reduced tumor growth to a larger extent than treatment with each drug alone.ConclusionsFABP5 inhibitors increase the cytotoxic and tumor‐suppressive effects of taxanes in PCa cells. The ability of these drugs to synergize could permit more efficacious antitumor activity while allowing for dosages of docetaxel or cabazitaxel to be lowered, potentially decreasing taxane‐resistance.
Quinclorac resistance in Echinochloa phyllopogon is associated with reduced ethylene synthesis rather than enhanced cyanide detoxification by β‐cyanoalanine synthase
Authors: Chayapakdee Pattarasuda , Sunohara Yukari , Endo Masaki , Yamaguchi Takuya , Fan Longjiang , Uchino Akira , Matsumoto Hiroshi , Iwakami Satoshi 
Published: October 2019

AbstractBACKGROUNDMultiple herbicide resistant Echinochloa phyllopogon exhibits resistance to the auxin herbicide quinclorac. Previous research observed enhanced activity of the cyanide‐detoxifying enzyme β‐cyanoalanine synthase (β‐CAS) and reduced ethylene production in the resistant line, suggesting β‐CAS‐mediated cyanide detoxification and insensitivity to quinclorac stimulation as the resistance mechanisms. To investigate the molecular mechanisms of quinclorac resistance, we characterized the β‐CAS genes alongside plant transformation studies. The association of β‐CAS activity and ethylene production to quinclorac resistance was assayed in the F6 progeny of susceptible and resistant lines of E. phyllopogon.RESULTSA single nucleotide polymorphism in a β‐CAS1 intron deleted aberrantly spliced mRNAs and enhanced β‐CAS activity in the resistant line. The enhanced activity, however, was not associated with quinclorac resistance in F6 lines. The results were supported by lack of quinclorac resistance in Arabidopsis thaliana expressing E. phyllopogon β‐CAS1 and no difference in quinclorac sensitivity between β‐CAS knockout and wild‐type rice. Reduced ethylene production co‐segregated with quinclorac resistance in F6 lines which were previously characterized to be resistant to other herbicides by an enhanced metabolism.CONCLUSIONβ‐CAS does not participate in quinclorac sensitivity in E. phyllopogon. Our results suggest that a mechanism(s) leading to reduced ethylene production is behind the resistance. © 2019 Society of Chemical Industry
Absolute quantification of urinary neutrophil gelatinase‐associated lipocalin by ultra‐high‐performance liquid chromatography/tandem mass spectrometry and the diagnostic efficacy of acute kidney injury
Authors: Ji Huoyan , Xu Lili , Su Jianyou , Shen Lei , Wang Huimin , Wang Jianxin , Wang Feng , Ju Shaoqin 
Published: October 2019

RationaleTo establish an absolute quantification method for neutrophil gelatinase‐associated lipocalin (NGAL) by ultra‐high‐performance liquid chromatography tandem positive ion electrospray ionization mass spectrometry (UHPLC/MS/MS) and evaluate its diagnostic efficacy for acute kidney injury (AKI).MethodsThree target peptides of NGA were prescreened by Skyline software, and two of them could be detected in tryptic peptides of NGAL recombinant protein and human urinary NGAL (uNGAL). Peptide (WYVVGLAGNAILR) was then selected as surrogate peptide. The corresponding isotope‐labeled peptide as the internal standard was next synthesized. Quantification of uNGAL was based on equations of linear regression, and method validation was then conducted. The diagnostic efficacy of uNGAL for AKI was also evaluated using receiver operating characteristic curve (ROC) analysis. Lastly, the UHPLC/MS/MS and the particle‐enhanced turbidimetric immunoassay (PETIA) methods for uNGAL quantification were compared.ResultsFor the y9 and y10 product ions, the linear regression equations were y = 2.5519x–4.6955 (R2 = 0.994, P<.01) and y = 2.4619x–4.3 (R2 =0.993, P<.01), respectively, and both of the linear ranges were from 0.5 to 15 mg/L. The limits of detection and quantification were 0.037 mg/L and 0.081 mg/L, respectively. The recoveries were from 97.32% to 107.28% at different uNGAL levels, and the within‐ and between‐day CVs for uNGAL quantification were from 0.22% to 7.65% and from 0.66% to 5.97%, respectively. The carryover rates of uNGAL were in the range of 0.70%–0.99%. The area under the ROC curve (AUC) of uNGAL was 0.96 (P<0.01), and the sensitivity and specificity of uNGAL for AKI diagnosis were 90.0% and 92.5%, respectively. In addition, the UHPLC/MS/MS and PETIA methods showed good agreement for uNGAL quantification (y = 0.7112x–0.0139, P = 0.34).ConclusionsThe UHPLC/MS/MS method for uNGAL quantification has a wide linear range, high sensitivity, precision, and recovery, and low carryover rates, and uNGAL detected by this method had high sensitivity and specificity for AKI diagnosis.
Focus on Spinel Li4Ti5O12 as Insertion Type Anode for High‐Performance Na‐Ion Batteries
Authors: Natarajan Subramanian , Subramanyan Krishnan , Aravindan Vanchiappan 
Published: October 2019

AbstractSodium‐ion batteries (SIBs) toward large‐scale energy storage applications has fascinated researchers in recent years owing to the low cost, environmental friendliness, and inestimable abundance. The similar chemical and electrochemical properties of sodium and lithium make sodium an easy substitute for lithium in lithium‐ion batteries. However, the main issues of limited cycle life, low energy density, and poor power density hamper the commercialization process. In the last few years, the development of electrode materials for SIBs has been dedicated to improving sodium storage capacities, high energy density, and long cycle life. The insertion type spinel Li4Ti5O12 (LTO) possesses “zero‐strain” behavior that offers the best cycle life performance among all reported oxide‐based anodes, displaying a capacity of 155 mAh g−1 via a three‐phase separation mechanism, and competing for future topmost high energy anode for SIBs. Recent reports offer improvement of overall electrode performance through carbon coating, doping, composites with metal oxides, and surface modification techniques, etc. Further, LTO anode with its structure and properties for SIBs is described and effective methods to improve the LTO performance are discussed in both half‐cell and practical configuration, i.e., full‐cell, along with future perspectives and solutions to promote its use.
Revisiting the molluscan fauna from the Cambrian (Series 2, stages 3–4) Xinji Formation of North China
Authors: Li Luoyang , Zhang Xingliang , Skovsted Christian B. , Yun Hao , Pan Bing , Li Guoxiang 
Published: October 2019

AbstractA diverse group of molluscs from the Cambrian Series 2, Stages 3–4 Xinji Formation of the North China Block (NCB) is described, based on more than 4500 specimens from three well‐studied sections in Shaanxi and Henan provinces, along the southern and southwestern margin of theNCB. Twenty molluscan species are identified, including one bivalve, three stem group gastropods, and 16 additional helcionelloids. Among these, six helcionelloid species are reported from theNCBfor the first time, and one new species,Parailsanella luonanensissp. nov. is proposed. This diverse molluscan fauna shares a large number of species with contemporaneous faunas of South Australia (15), Antarctica (7), Laurentia (6), Siberia (3) and South China (1). Faunal similarities are even greater on a generic level. The striking similarities of the molluscan faunas of North China, South Australia and Antarctica strongly support the hypothesis that theNCBwas situated close to Eastern Gondwana, most likely close to South Australia in the Cambrian Epoch 2. In addition, well‐preserved shell attachment muscle scars were observed in the helcionelloidFigurina figurina, with two pairs of symmetrical, continuous, band‐like muscle scars, which are obviously different from the musculature of both gastropods and monoplacophorans. Because of this unique musculature, these characteristic Cambrian cap‐like molluscs are assigned to the Helcionelloida rather than to the Gastropoda or Monoplacophora.
Fluorescence lifetime imaging for intraoperative cancer delineation in transoral robotic surgery
Authors: Weyers Brent W. , Marsden Mark , Sun Tianchen , Bec Julien , Bewley Arnaud F. , Gandour‐Edwards Regina F. , Moore Michael G. , Farwell D. Gregory , Marcu Laura 
Published: October 2019

AbstractThis study evaluates the potential for fluorescence lifetime imaging (FLIm) to enhance intraoperative decisionmaking during robotic‐assisted surgery of oropharyngeal cancer. Using a custom built FLIm instrument integrated with the da Vinci robotic surgical platform, we first demonstrate that cancer in epithelial tissue diagnosed by histopathology can be differentiated from surrounding healthy epithelial tissue imaged in vivo prior to cancer resection and ex vivo on the excised specimen. Second, we study the fluorescence properties of tissue imaged in vivo at surgical resection margins (tumor bed). Fluorescence lifetimes and spectral intensity ratios were calculated for three spectral channels, producing a set of six FLIm parameters. Current results from 10 patients undergoing TORS procedures demonstrate that healthy epithelium can be resolved from cancer (P < .001) for at least one FLIm parameter. We also showed that a multiparameter linear discriminant analysis approach provides superior discrimination to individual FLIm parameters for tissue imaged both in vivo and ex vivo. Overall, this study highlights the potential for FLIm to be developed into a diagnostic tool for clinical cancer applications of the oropharynx. This technique could help to circumvent the issues posed by the lack of tactile feedback associated with robotic surgical platforms to better enable cancer delineation.
Revisiting Critical Literacy in the Digital Age
Authors: Burnett Cathy , Merchant Guy 
Published: October 2019

AbstractIn an age of environmental crisis, financial instability, widespread migration, and political extremism, the case for critical literacy is pressing. Navigating criticality in the digital age, however, is challenging, not least because digital media, digital devices, and digital architectures are implicated in broader social, cultural, commercial, and political activity. Critical literacy in this context needs to do more than focus on the significance of texts within networks of humans. The authors developed a model designed to support a relational approach to critical literacy, drawing on a sociomaterial perspective to consider how broader social‐material networks help generate meanings that may amplify, undermine, or contradict the activities of individuals and groups. The authors end with questions that provide a starting point for broadening the scope of critical literacy in education to reflect on relationships among people, texts, and materials across time and spaces.
Coaching and Professional Learning: Looking for Inspiration
Authors: Morgan Denise N. , Bates Celeste C. , Aker Lisa D. , Dawson Jaime , Doswell Becca D. , Lancaster Pam , Puig Enrique A. , Williams Jeff L. 
Published: October 2019

AbstractTeaching is a profession that requires ongoing professional development and learning. This ongoing learning can take place in professional learning communities, structured professional development settings, and literacy coaching contexts. This department highlights the ongoing professional development of literacy teachers.
Computational prediction of protein–protein binding affinities
Authors: Siebenmorgen Till , Zacharias Martin 
Published: October 2019

AbstractProtein–protein interactions form central elements of almost all cellular processes. Knowledge of the structure of protein–protein complexes but also of the binding affinity is of major importance to understand the biological function of protein–protein interactions. Even weak transient protein–protein interactions can be of functional relevance for the cell during signal transduction or regulation of metabolism. The structure of a growing number of protein–protein complexes has been solved in recent years. Combined with docking approaches or template‐based methods, it is possible to generate structural models of many putative protein–protein complexes or to design new protein–protein interactions. In order to evaluate the functional relevance of putative or predicted protein–protein complexes, realistic binding affinity prediction is of increasing importance. Several computational tools ranging from simple force‐field or knowledge‐based scoring of single protein–protein complexes to ensemble‐based approaches and rigorous binding free energy simulations are available to predict relative and absolute binding affinities of complexes. With a focus on molecular mechanics force‐field approaches the present review aims at presenting an overview on available methods and discussing advantages, approximations, and limitations of the various methods.This article is categorized under:
Molecular and Statistical Mechanics > Molecular Interactions
Molecular and Statistical Mechanics > Free Energy Methods
Software > Molecular Modeling
A review of approximate Bayesian computation methods via density estimation: Inference for simulator‐models
Authors: Grazian Clara , Fan Yanan 
Published: October 2019

AbstractThis paper provides a review of approximate Bayesian computation (ABC) methods for carrying out Bayesian posterior inference, through the lens of density estimation. We describe several recent algorithms and make connection with traditional approaches. We show advantages and limitations of models based on parametric approaches and we then draw attention to developments in machine learning, which we believe have the potential to make ABC scalable to higher dimensions and may be the future direction for research in this area.This article is categorized under:
Algorithms and Computational Methods < Algorithms
Statistical and Graphical Methods of Data Analysis < Bayesian Methods and Theory
Statistical Models < Simulation Models
Science Data Products for AMPERE
Authors: Waters Colin L. , Anderson B. J. , Green D. L. , Korth H. , Barnes R. J. , Vanhamäki Heikki 
Published: October 2019

AbstractBirkeland currents that flow in the auroral zones produce perturbation magnetic fields that may be detected using magnetometers onboard low-Earth orbit satellites. The Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE) uses magnetic field data from the attitude control system of each Iridium satellite. These data are processed to obtain the location, intensity and dynamics of the Birkeland currents. The methodology is based on an orthogonal basis function expansion and associated data fitting. The theory of magnetic fields and currents on spherical shells provides the mathematical basis for generating the AMPERE science data products. The application of spherical cap harmonic basis and elementary current system methods to the Iridium data are discussed and the procedures for generating the AMPERE science data products are described.