bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced rate capabilities in a glass-ceramic-derived sodium all-solid-state battery
Authors: Yamauchi Hideo , Ikejiri Junichi , Tsunoda Kei , Tanaka Ayumu , Sato Fumio , Honma Tsuyoshi , Komatsu Takayuki 
Published: June 2020

AbstractAn all-solid-state battery (ASSB) with a new structure based on glass-ceramic that forms Na2FeP2O7 (NFP) crystals, which functions as an active cathode material, is fabricated by integrating it with a β″-alumina solid electrolyte. Two important factors that influence the rate capability of this ASSB were optimised. First, the particle size of the precursor glass powder from which the NFP crystals are formed was decreased. Consequently, the onset temperature of crystallisation shifts to a lower temperature, which enables the softening of NFP crystals and their integration with β″-alumina at a low temperature, without the interdiffusion of different crystal phases or atoms. Second, the interface between the β″-alumina solid electrolyte and cathode active materials which consisted of the NFP-crystallised glass and acetylene black used as a conductive additive, is increased to increase the insertion/release of ions and electrons from the active material during charge/discharge processes. Thus, the internal resistance of the battery is reduced considerably to 120 Ω. Thus, an ASSB capable of rapid charge/discharge that can operate not only at room temperature (30 °C) but also at −20 °C is obtained. This technology is an innovative breakthrough in oxide-based ASSBs, considering that the internal resistance of liquid electrolyte-based Li-ion batteries and sulphide-based ASSBs is ~10 Ω.
Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model
Authors: Karbowska Malgorzata , Hermanowicz Justyna M. , Tankiewicz-Kwedlo Anna , Kalaska Bartlomiej , Kaminski Tomasz W. , Nosek Krzysztof , Wisniewska Roza J. , Pawlak Dariusz 
Published: June 2020

AbstractChronic kidney disease (CKD) is deemed to be a worldwide health concern connected with neurological manifestations. The etiology of central nervous system (CNS) disorders in CKD is still not fully understood, however particular attention is currently being paid to the impact of accumulated toxins. Indoxyl sulfate (IS) is one of the most potent uremic toxins. The purpose of the present study was to assess IS concentrations in the cerebellum, brainstem, cortex, hypothalamus, and striatum with hippocampus of rats chronically exposed to IS. To evaluate IS impact on neurochemical and behavioral alterations, we examined its influence on brain levels of norepinephrine, epinephrine, dopamine, serotonin and their metabolites, as well as changes in behavioral tests (open field test, elevated plus maze test, chimney test, T maze test, and splash test). Our results show the highest IS accumulation in the brainstem. IS leads to behavioral alterations involving apathetic behavior, increased stress sensitivity, and reduced locomotor and exploratory activity. Besides, IS contributes to the impairment of spatial memory and motor coordination. Furthermore, we observed reduced levels of norepinephrine, dopamine or serotonin, mainly in the brainstem. Our findings indicate that IS can be one of the crucial uremic factors responsible for altered mental status in CKD.
Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation
Authors: Nakahara Takeshi , Kido-Nakahara Makiko , Ulzii Dugarmaa , Miake Sho , Fujishima Kei , Sakai Sawako , Chiba Takahito , Tsuji Gaku , Furue Masutaka 
Published: June 2020

AbstractEndothelin-1 (ET-1) is well known as the most potent vasoconstrictor, and can evoke histamine-independent pruritus. Recently, its involvement in cutaneous inflammation has begun to draw attention. The upregulation of ET-1 expression in the epidermis of human psoriasis patients has been reported. It was also demonstrated that ET-1 can stimulate dendritic cells to induce Th17/1 immune responses. However, the role of the interaction between ET-1 and ET-1 receptors in the pathogenesis of psoriasis remains elusive. Here, we investigated the effects of ET-1 receptor antagonist on imiquimod (IMQ) -induced psoriasiform dermatitis in mouse. Psoriasis-related cytokines such as IL-17A and TNF-α induced ET-1 expression in human keratinocytes. Topical application of selective endothelin A receptor (ETAR) antagonist ambrisentan significantly attenuated the development of IMQ-induced psoriasiform dermatitis and also significantly inhibited the histological inflammation and cytokine expression (TNF-α, IL-12p40, IL-12 p19, and IL-17) in the lesional skin of the mouse model. Furthermore, topical application of ambrisentan suppressed phenotypic and functional activation of dendritic cells in lymph nodes. Our findings indicate that the ET-1 and ETAR axis plays an important role in the pathogenesis of psoriasis and is a potential therapeutic target for treating psoriasis.
Activated α2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion
Authors: Bastida-Ruiz Daniel , Wuillemin Christine , Pederencino Aude , Yaron Michal , Martinez de Tejada Begoña , Pizzo Salvatore Vincent , Cohen Marie 
Published: June 2020

AbstractThe villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been suggested that cell surface glucose-regulated protein 78 (GRP78) was involved in this process. In multiple cancer cells, cell membrane-located GRP78 has been reported to act as a receptor binding to the active form of α2-macroglobulin (α2M*), activating thus several cellular signalling pathways implicated in cell growth and survival. We hypothesised that GRP78 interaction with α2M* may also activate signalling pathways in trophoblastic cells, which, in turn, may promote cell fusion. Here, we observed that α2M mRNA is highly expressed in trophoblastic cells, whereas it is not expressed in the choriocarcinoma cell line BeWo. We thus took advantage of forskolin-induced syncytialisation of BeWo cells to study the effect of exogenous α2M* on syncytialisation. We first demonstrated that α2M* induced trophoblastic cell fusion. This effect is dependent on α2M*-GRP78 interaction, ERK1/2 and CREB phosphorylation, and unfolded protein response (UPR) activation. Overall, these data provide novel insights into the signalling molecules and mechanisms regulating trophoblastic cell fusion.
Mir34a constrains pancreatic carcinogenesis
Authors: Hidalgo-Sastre Ana , Lubeseder-Martellato Clara , Engleitner Thomas , Steiger Katja , Zhong Suyang , Desztics Judit , Öllinger Rupert , Rad Roland , Schmid Roland M. , Hermeking Heiko , Siveke Jens T. , von Figura Guido 
Published: June 2020

AbstractSeveral studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active mutation of the oncogene Kras and loss of function of the tumour suppressor Tp53 gene. Since the MicroRNA 34a (Mir34a) is a direct target of Tp53 it may critically contribute to the suppression of PDAC. Mir34a is epigenetically silenced in numerous cancers, including PDAC, where Mir34a down-regulation has been associated with poor patient prognosis. To determine whether Mir34a represents a suppressor of PDAC formation we generated an in vivo PDAC-mouse model harbouring pancreas-specific loss of Mir34a (KrasG12D; Mir34aΔ/Δ). Histological analysis of KrasG12D; Mir34aΔ/Δ mice revealed an accelerated formation of pre-neoplastic lesions and a faster PDAC development, compared to KrasG12D controls. Here we show that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells. Our results imply that Mir34a restrains PDAC development by modulating the immune microenvironment of PDAC, thus defining Mir34a restauration as a potential therapeutic strategy for inhibition of PDAC development.
Abduction treatment in stable hip dysplasia does not alter the acetabular growth: results of a randomized clinical trial
Authors: Pollet V. , Castelein R. M. , van de Sande M. , Witbreuk M. , Mostert A. K. , Besselaar A. , van Bergen C. , Beek E. , Uiterwaal C. S. P. M. , Sakkers R. J. B. 
Published: June 2020

AbstractBackground The effect of bracing over natural history of stable dysplastic hips is not well known. This multicenter randomized trial aimed at objectifying the effect of abduction treatment versus active surveillance in infants of 3 to 4 months of age. Methods Patients were randomized to either Pavlik harness or active surveillance group. Ultrasound was repeated at 6 and 12 weeks post randomization. The primary outcome was the degree of dysplasia using the Graf α-angle at 6 months of age. The measurement of the acetabular index (AI) on plain pelvis X-rays was used to identify persistent dysplasia after 9 months and walking age (after 18 months). Findings The Pavlik harness group (n = 55) and active surveillance group (n = 49) were comparable for predictors of outcome. At 12 weeks follow-up the mean α-angle was 60.5° ± 3.8° in the Pavlik harness group and 60.0° ± 5.6° in the active surveillance group. (p = 0.30). Analysis of secondary outcomes (standard of care) showed no treatment differences for acetabular index at age 10 months (p = 0.82) and walking age (p = 0.35). Interpretation Pavlik harness treatment of stable but sonographic dysplastic hips has no effect on acetabular development. Eighty percent of the patients will have a normal development of the hip after twelve weeks. Therefore, we recommend observation rather than treatment for stable dysplastic hips.
Evaluation of carbon tetrachloride fraction of Actinodaphne angustifolia Nees (Lauraceae) leaf extract for antioxidant, cytotoxic, thrombolytic and antidiarrheal properties
Authors: Uddin Mohammad Najim , Alam Towsif , Islam Muhammad Azharul , Khan Tawhidul Amin , Zaman Raihan Uz , Azam Shofiul , Kamal ATM Mostafa , Jakaria Md. 
Published: June 2020

Abstract
Actinodaphne angustifolia Nees (Family: Lauraceae) is commonly used in folk medicine against urinary disorder and diabetes. The objective of the present study was to evaluate the antioxidant, cytotoxic, thrombolytic, and antidiarrheal activities of carbon tetrachloride (CCl4) fraction of leaves of A. angustifolia (CTFAA) in different experimental models. Antioxidant activity was evaluated by using qualitative and quantitative assays, while antidiarrheal effects assessed with castor oil-induced diarrheal models in mice. The clot lysis and brine shrimp lethality bioassay were used to investigate the thrombolytic and cytotoxic activities, respectively. CTFAA showed antioxidant effects in all qualitative and quantitative procedures. The fraction produced dose-dependent and significant (P&lt;0.05 and P&lt;0.01) activities in castor oil-induced diarrheal models. Moreover, CTFAA significantly (P&lt;0.05) demonstrated a 15.29% clot lysis effect in the thrombolytic test, and the brine shrimp lethality assay LC50 value was 424.16 μg/ml bioassay. In conclusion, the current study showed CTFAA has significant antidiarrheal effects along with modest antioxidant and thrombolytic effects, and these data warrant further experiment to justify and include CTFAA as a supplement to mitigate the onset of diarrheal and cardiovascular disease.
Cognitive, Noncognitive, and Home Environment Correlates of Reading Difficulties in Primary-Grade Students With Language Impairment
Authors: Newbury Jayne , Justice Laura M. , Jiang Hui H. , Schmitt Mary Beth 
Published: June 2020

Purpose
This article first aimed to examine the cognitive (rapid automatized naming, phonological awareness, working memory, nonverbal cognition, and language) correlates of reading difficulty in children with language impairment (LI). Second, we considered whether noncognitive (effortful control, social competence, and behavior problems) correlates offered any explanatory value above that of cognitive factors. Third, we examined whether home environment (specifically household organization and home learning environment) would offer an additional explanatory value.

Method
The sample included 165 children in kindergarten and Grade 1 who were receiving intervention for LI in public schools. Standardized measures along with parent interviews/questionnaires were administered at the end of the school year.

Results
Logistic regression models indicated the noncognitive factors added discriminatory value to that of cognitive factors in predicting reading difficulties, whereas household factors did not. In the final model using all 11 predictors, prediction accuracy was 88.7% for the typical reading group and 54.2% for the reading difficulty group, with an overall accuracy of 76.4%. Only phonological awareness and working memory significantly contributed to predicting reading group membership when measured in kindergarten and Grade 1.

Conclusions
For this sample of children with LI, the most important predictors of reading were cognitive. The child's behavior and social competence improved prediction to a limited but statistically significant degree, whereas home environment did not. Overall classification was low, as only half of the children with reading difficulties were correctly predicted. Important factors differentiating good and poor emergent readers with LI were not captured in this study.

Supplemental Material

https://doi.org/10.23641/asha.12462428
Stroke controllable style transfer based on dilated convolutions
Authors: Xu Zhaopan , Zhang Juan , Zhang Yu , Zhou Mingquan , Li Kang , Geng Shengling , Zhang Xiaojuan 
Published: June 2020

Transferring a photo to a stylised image with beautiful texture has become one of the most popular topics in computer vision and the application of image processing. Controlling the stroke size of the texture is one of the challenging problems in this task. Recent representative methods for such problem introduce a pyramid model to regulate receptive fields in the network. Meanwhile, dilated convolutions are proved to be a very efficient way to adjust receptive fields without losing resolution. By combining the advantages of both approaches and making special optimisation for VGG19 model for style transfer tasks, the authors propose to exploit dilated convolutions to extract texture information endowing the network with stroke controllable. Several sets of contrast experiments were conducted and results show that their algorithm can generate more attractive stylisation images and control stroke size flexibly. It demonstrates the superiority of applying dilated convolutions as a texture extraction method for maintaining more texture information and controlling stroke size.
Was ist sexualisierte Gewalt in organisierten und rituellen Strukturen?
Authors: Behrendt Pia , Nick Susanne , Briken Peer , Schröder Johanna 
Published: June 2020

Zusammenfassung
Einleitung Sexueller Kindesmissbrauch in organisierten und rituellen Strukturen (ORG) beinhaltet vernetzte TäterInnen-Gruppen mit einem ideologischen Überbau. Die definitorische Unschärfe des Begriffes „rituell“ erschwert den fachlichen Diskurs und die Aufklärung der Gesellschaft.
Forschungsziele Die vorliegende Studie verfolgt das Ziel herauszuarbeiten, wie Betroffene und ZeitzeugInnen organisierte und rituelle Merkmale der sexualisierten Gewalt beschreiben, um die Definition von ORG weiter ausdifferenzieren zu können.
Methoden Im Rahmen eines von der Unabhängigen Kommission zur Aufarbeitung sexuellen Kindesmissbrauchs (UKASK) geförderten Projekts wurden 23 Transkripte vertraulicher Anhörungen (offene bis teilstrukturierte Interviews) sowie elf schriftliche Berichte von 33 Betroffenen und ZeitzeugInnen mittels eines mehrstufigen, inhaltsanalytischen Vorgehens ausgewertet (deduktiv-induktiv-deduktive Kategorienentwicklung).
Ergebnisse Die Struktur (z. B. vernetzte TäterInnen mit Einfluss auf Machtstrukturen) und Strategien (z. B. gezielte Aufspaltung und Konditionierung, oder Bedrohung) der TäterInnen-Gruppen wurden als organisierte Merkmale identifiziert. Weiterhin wurde die Verwendung von Ideologien (z. B. religiös, rechtsextrem, satanisch), Symbolik (z. B. Sprache, Objekte, Kleidung) und Praktiken (z. B. Zeremonien, Opferungen, Kannibalismus) als rituelle Merkmale gedeutet. Dabei entstand der Eindruck, dass die einzelnen Elemente eng miteinander verknüpft sind.
Schlussfolgerung Die Elemente ritueller Gewalt scheinen auf den Elementen organisierter Gewalt aufzubauen, eine Rechtfertigung der Gewalttaten zu bezwecken und diese gleichsam zu intensivieren. Rituelle Gewalt als einen ideologischen Subtyp organisierter Gewalt zu verstehen, kann die gesellschaftliche Aufklärung erleichtern und so die psychosoziale Versorgung betroffener Personen verbessern.
Hans Giese und seine Theorie der Homosexualität
Authors: Sigusch Volkmar 
Published: June 2020

ZusammenfassungWährend der 50er- und 60er-Jahre war Hans Giese (1920–1970) der einflussreichste und renommierteste Sexualforscher in Westdeutschland. Bis zu seinem Tod war er Direktor des Instituts für Sexualforschung an der Universität Hamburg. Dank seiner Bestrebungen gewann die Sexualforschung sowohl innerhalb als auch außerhalb akademischer Kreise an Ansehen. Aus der Sicht des Autors lag der Schlüssel von Gieses Werk in dessen eigener Homosexualität. Er suchte Wege, um die Homosexualität von ihrer Aura der Immoralität und Kriminalität zu befreien. In seiner Theorie der Homosexualität unterscheidet er zwischen disziplinierten, partnerorientierten und undisziplinierten, ungebundenen Homosexuellen. Die letzteren blieben Zielpersonen für medizinische Behandlung, rechtliche Sanktionen und moralische Urteile. In diesem Sinne gelang es Giese trotz seiner liberalen Einstellungen und Errungenschaften im Hinblick auf eine Entkriminalisierung der männlichen Homosexualität nicht, das Tabu zu durchbrechen, welches noch immer auf der Homosexualität lastet.
Effect of Orthodontic Treatment on Tooth Autotransplantation: Systematic Review of Controlled Clinical Trials
Authors: Lacerda-Santos Rogério , Canutto Rhaíssa Ferreira , Araújo José Lucas dos Santos , Carvalho Fabiola Galbiatti de , Münchow Eliseu Aldrighi , Barbosa Taís de Souza , Pithon Matheus Melo , Rego Emanuel Braga , Neves Leniana Santos 
Published: June 2020

AbstractThis systematic review was focused on evaluating tooth autotransplantation, considering its impacts on the teeth, bone, soft tissues, and aesthetics in orthodontic patients. A bibliographic search was conducted without limitations on year of publication or language in the databases of PubMed, Web of Science, Scopus, Medline Complete, Cochrane, Clinical Trials, and Trials Central. For triage of articles, indications, surgical planning, orthodontic movement, risk factors for treatment, and long-term follow-ups were considered. For outcomes, the results with reference to teeth, alveolar bone, periodontal tissues, and esthetic satisfaction were considered. Risk of bias was evaluated using the methodological index for nonrandomized studies-MINORS. The results showed 10 controlled clinical trials, and no randomized clinical trials were found. The selected studies included 715 patients and 934 autotransplanted teeth among which there were premolars, molars, and anterior teeth evaluated in the long term, indicating that orthodontics associated with autotransplantation indicated a result that was generally clinically acceptable. The quality of the set of evidence was considered medium due to the presence of different methodological problems, risk of bias, and significant heterogeneity in the evaluated studies. There was a sufficient body of evidence that justified autotransplantation in patients who needed orthodontic movement. In teeth, there was an increase in root resorption influenced by orthodontics, but without impacting on the general clinical result in the long term. Bone and periodontal tissue do not appear to be affected by orthodontics. The patient’s aesthetic satisfaction was not considered in the studies.
Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
Authors: Sundaram Mouleeswaran , Bansal Sonia , Surve Rohini M. 
Published: June 2020

AbstractFactor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of activated partial thromboplastin time (aPTT). This aPTT prolongation is expected to cause increased bleeding during surgery. However, on the contrary, in vivo isolated factor XII deficiency is associated with increased risk of thromboembolism (this risk being higher than the risk of bleeding). We report the perioperative management of a patient with factor XII deficiency who underwent cervical vertebral fusion (C1–C2) for atlantoaxial dislocation.
Writing and language learning
Authors: Manchón Rosa M. 
Published: June 2020

Abstract
This introductory chapter serves two main purposes. One is to contextualize the book within the
larger professional discussion, which entails a look back approach in order to provide a synthetic review of key
milestones and developments in the study of writing as a site for language learning. The second aim is to introduce
readers to the aims, structure, and contents of the book. To this end, I (a) outline the key elements of the various
contributions to the book and the way in which they are framed in a common research agenda; (b) describe the
interconnection among contributions and the internal coherence of the volume; and (c) advance the way in which the
book attempts to move theory and research forward.
Effects of task repetition with the aid of direct and indirect written corrective feedback
Authors: Amelohina Victoria , Nicolás-Conesa Florentina , Manchón Rosa M. 
Published: June 2020

Abstract
This study sheds light on the learning affordances of task repetition in writing by analyzing the
effects of exact task repetition (2 iterations of the same task) and procedural task repetition (2 task types, each
one performed twice over 6 months) aided with written corrective feedback (WCF). The participants were 19 EFL students
enrolled in an out-of-school instructional program. Two sequences of direct and indirect WCF were implemented and
potential differences in terms of CAF measures of the texts produced in a new iteration of the task and across tasks
and time were examined. Results showed linear and non-linear effects of task repetition with WCF on diverse components
of CAF, as well as a differential appropriation of indirect WCF across time. Theoretical and methodological
implications for the learning affordances of task repetition in the environment of writing are drawn.
A mixed-methods approach to exploring the L2 learning potential of writing versus speaking
Authors: Zalbidea Janire 
Published: June 2020

Abstract
The study reported in this chapter investigated the extent to which task modality can impact L2
learners’ (a) noticing of the target form, (b) target form incorporation, and (c) perceptions of task-induced demands
in a grammar-focused task. Using a mixed-methods approach, three sources of information were examined: (a) stimulated
recall protocols, (b) learners’ task performance, and (c) subjective post-task questionnaires. Although both task
modality conditions led to substantial noticing and form incorporation, along with similar ratings of task demands,
participants in the writing condition were more accurate in incorporating the target form into their own output.
Findings are discussed in terms of their implications for the L2 learning potential of writing versus speaking and the
contributions of mixed-methods approaches to the study of task modality in SLA.