bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical efficacy and safety of kanglaite adjuvant therapy in the treatment of advanced hepatocellular carcinoma: A PRISMA-compliant meta-analysis
Authors: Liu Jingjing , Liu Xueni , Ma Jing , Li Ke , Xu Chao 
Published: November 2019

Abstract
Kanglaite, a type of Chinese medicine preparation, is considered a promising complementary therapy option for advanced hepatocellular carcinoma (HCC). Although an analysis of the published literature has been performed, the exact effects and safety are yet to be systematically investigated. Therefore, we conducted a wide-ranging online search of electronic databases to provide systematic conclusions; data from 31 trials with 2315 HCC patients were included. The results indicated that compared with conventional treatment (CT) alone, the combination of kanglaite with CT markedly prolonged patients’ 6-month overall survival (OS, P=0.003), 12-month OS (P&lt;0.0001), 18-month OS (P=0.003), 24-month OS (P=0.03) and 36-month OS (P=0.0006) and significantly improved the overall response rate (odds ratio (OR) = 2.57, 95% confidence interval (CI) = 2.10–3.16, P&lt;0.00001) and disease control rate (OR = 3.10, 95% CI = 2.42–3.97, P&lt;0.00001) of patients. The quality of life (QoL), clinical symptoms and immune function of patients were also obviously improved after combined treatment. The incidence rates of nausea and vomiting (P=0.04), hepatotoxicity (P=0.0002), leukopenia (P&lt;0.00001), thrombocytopenia (P&lt;0.0001), gastrointestinal side effects (P=0.01) and fever (P&lt;0.0009) were lower in the group receiving CT and kanglaite than in the group receiving CT alone. In summary, the combination of kanglaite and CT is safe and more effective in treating HCC than is CT alone, and its application in the clinic is worth promoting.
Analysis and design considerations of an axial‐flux dual‐rotor consequent‐pole Vernier‐PM machine for direct‐drive energy conversion systems
Authors: Gorginpour Hamed 
Published: November 2019

The Vernier permanent‐magnet (VPM) machine is known as high‐torque and low‐speed drive solution suitable for direct‐drive applications such as electric‐vehicles and wind‐turbines. This study presents a high‐efficiency axial‐flux VPM machine with dual‐rotor of consequent‐pole topology and one yoke‐less concentrated‐winding stator. The consequent‐pole VPM machine is a special VPM structure that introduces high torque‐density as the conventional‐VPM machine incorporating a significantly lower volume of PM material. The proposed machine represents desirable features of higher efficiency, improved reliability and lower weight and axial‐length compared to the traditional motor‐gearbox approach. These advantages are achieved due to: dual‐PM rotors for appropriate forming the magnetic flux lines and increasing torque‐to‐weight ratio, yokeless‐stator for reducing flux path, concentrated winding with no overhang for reducing copper‐loss, using rectangular‐shaped copper conductors for increasing winding fill factor and selecting the core material from high‐performance grain‐oriented magnetic steel for reducing core‐loss. After presenting the structure, the operating principles are discussed based on the magnetic flux behaviour and a quasi‐3D magnetic‐equivalent‐circuit model is extracted. The accuracy of the analytical model is validated by comparing the results with the FE results. Finally, the effects of the design parameters on electro‐magnetic performance are analytically investigated by studying a 10 kW machine.
Grayscale Ultrasound Radiomic Features and Shear-Wave Elastography Radiomic Features in Benign and Malignant Breast Masses
Authors: Youk Ji Hyun , Kwak Jin Young , Lee Eunjung , Son Eun Ju , Kim Jeong-Ah 
Published: November 2019

Abstract
Purpose To identify and compare diagnostic performance of radiomic features between grayscale ultrasound (US) and shear-wave elastography (SWE) in breast masses.
Materials and Methods We retrospectively collected 328 pathologically confirmed breast masses in 296 women who underwent grayscale US and SWE before biopsy or surgery. A representative SWE image of the mass displayed with a grayscale image in split-screen mode was selected. An ROI was delineated around the mass boundary on the grayscale image and copied and pasted to the SWE image by a dedicated breast radiologist for lesion segmentation. A total of 730 candidate radiomic features including first-order statistics and textural and wavelet features were extracted from each image. LASSO regression was used for data dimension reduction and feature selection. Univariate and multivariate logistic regression was performed to identify independent radiomic features, differentiating between benign and malignant masses with calculation of the AUC.
Results Of 328 breast masses, 205 (62.5 %) were benign and 123 (37.5 %) were malignant. Following radiomic feature selection, 22 features from grayscale and 6 features from SWE remained. On univariate analysis, all 6 SWE radiomic features (P < 0.0001) and 21 of 22 grayscale radiomic features (P < 0.03) were significantly different between benign and malignant masses. After multivariate analysis, three grayscale radiomic features and two SWE radiomic features were independently associated with malignant breast masses. The AUC was 0.929 for grayscale US and 0.992 for SWE (P < 0.001).
Conclusion US radiomic features may have the potential to improve diagnostic performance for breast masses, but further investigation of independent and larger datasets is needed.
Prediction of Adnexal Torsion by Ultrasound in Women with Acute Abdominal Pain
Authors: Bardin Ron , Perl Noga , Mashiach Reuven , Ram Eitan , Orbach-Zinger Sharon , Shmueli Anat , Wiznitzer Arnon , Hadar Eran 
Published: November 2019

Abstract
Purpose To investigate the accuracy of ultrasound in the diagnosis of adnexal torsion.
Materials and Methods Retrospective cohort analysis of 322 women, presenting to a tertiary medical center with acute abdominal pain, who underwent gynecological examination, sonographic evaluation and laparoscopic surgery, between 2010 and 2016. Findings for adnexal torsion were compared among three groups: positive sonographic findings consistent with surgically confirmed adnexal torsion (true positive, n = 228); negative sonographic findings inconsistent with surgically confirmed adnexal torsion (false negative, n = 42); and positive sonographic findings inconsistent with a surgical diagnosis other than adnexal torsion (false positive, n = 52). Outcome measures were sensitivity and positive predictive value of ultrasound, and its specific features, for the diagnosis of adnexal torsion.
Results The sensitivity of ultrasound for adnexal torsion diagnosis was 84.4 %, and the positive predictive value was 81.4 %. Edematous ovary and/or tube, as well as positive whirlpool sign had the highest sensitivity and positive predictive value. The false-negative group had the highest frequency of ovarian cysts (p = 0.0086) and the lowest frequency of ovarian edema (p < 0.0001). The false-positive group had the lowest proportion of pregnant women (p = 0.0022). Significantly more women in the true-positive group had a prior event of adnexal torsion (p = 0.026).
Conclusion Ultrasound examination is highly accurate in the diagnosis of adnexal torsion. Clinicians should be aware of the presence of demographic and clinical characteristics that may positively or negatively affect sonographic diagnostic accuracy.
Traumatic Posterior Fossa Hematoma, A Rare Entity: Study of 21 Cases
Authors: Bhardwaj Sandeep , Sharma Vinod , Sharma Somnath , Purohit Devendra , Chopra Sanjeev 
Published: November 2019

Abstract
Background Traumatic posterior fossa hematoma is a rare entity. Traumatic posterior fossa hematomas are associated with considerable morbidity and mortality and their surgical management remained controversial.
Methods From August 2011 to August 2017, approximately 5,100 patients with head injury were managed. Authors reviewed clinical and radiological findings, management criteria, and outcome of posterior fossa hematoma in 21 patients.
Results Out of 21 cases, 13 survived with our management. The Glasgow Coma Scale (GCS) on admission was higher in favorable group than in poor outcome group. Factors associated with Glasgow Outcome Scale in two groups were status of fourth ventricle, basal cisterns, subarachnoid hemorrhage (SAH), hematoma volume, and their location (hemispheric or midline). Similarly, associated supratentorial lesions, age, gender, lesions in other parts of body, and timing from injury to reporting to hospital were taken into consideration.
Conclusion The factors correlated with patient outcome were age, sex, mode of injury, GCS at admission, associated intracranial hematomas, associated SAH, hematoma volume, hematoma location, basal cisterns, status of fourth ventricle, and associated multiple injuries on other body parts. It is hereby concluded that timely surgical intervention should be employed whenever indicated without delay. Posterior fossa hematomas were rarely observed in the pediatric age group.
PBMCs-Derived microRNA Signature as a Prethrombotic Status Discriminator in Stable Coronary Artery Disease
Authors: Gao Jie , Liu Jia , Zhang Ying , Guan BaoYi , Qu Hua , Chai Hua , Wang WenTing , Ma XiaoJuan , Shi DaZhuo 
Published: November 2019

AbstractPrethrombotic status (PTS) in patients with stable coronary artery disease (SCAD) increases the risk of coronary thrombosis. Accumulating evidences have indicated that micro-ribonucleic acids (miRNAs) may serve as promising biomarkers for SCAD patients with PTS. The present study aimed to identify the miRNA signature in SCAD patients with PTS and evaluated their diagnostic significance. In the screening phase, 32 differently expressed miRNAs (DEMs) in peripheral blood mononuclear cells (PBMCs) were detected in 35 SCAD patients compared with 5 healthy controls by microarray. MiRNA-gene network analysis was then performed, and 4 DEMs were selected for validation with reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) test in an independent cohort comprising 79 SCAD patients and 19 healthy controls. Compared with healthy controls, RT-qPCR test verified the upregulations of miR-34a-5p, miR-432–5p, and miR-370–3p detected by microarray; while the upregulation of miR-495–3p measured by RT-qPCR was not consistent with its low expression detected by microarray. Only miR-34a-5p and miR-495–3p were significantly upregulated in the PTS group compared with the non-PTS group (p < 0.01, p < 0.05). Receiver-operating characteristic (ROC) analysis showed that PBMCs-derived miR-34a-5p and miR-495–3p may discriminate PTS with the areas under the ROC curve (AUC) of 0.780 (confidence interval [CI]95% = 0.673–0.866) and 0.712 (CI95% = 0.599–0.808), respectively. The combination of miR-34a-5p and fibrinogen (FIB, a traditional biomarker for PTS) improved AUC to 0.885 (CI95% = 0.793–0.946) and showed added predictive ability compared with FIB, with an integrated discrimination improvement of 0.201 (p < 0.01). Therefore, the combination of miR-34a-5p and FIB may serve as an efficient tool for distinguishing PTS in SCAD patients.
Impacts of Hurricane Harvey on drinking water quality in two Texas cities
Authors: Landsman Matthew R , Rowles Lewis Stetson , Brodfuehrer Samuel H , Maestre Juan P , Kinney Kerry A , Kirisits Mary Jo , Lawler Desmond F , Katz Lynn E 
Published: November 2019

Abstract
Hurricane Harvey devastated large parts of the US Gulf Coast in 2017, and its floodwaters posed a number of threats to the environment and human health. In particular, an estimated 375 000 Texas residents experienced issues related to the provision of safe drinking water at the peak of the hurricane. In this study, physical, chemical, and biological water quality was monitored in two drinking water systems in Texas following Hurricane Harvey to understand the relationship between water quality parameters and changes in the drinking water microbiota. Results show initial surges in total organic carbon, trihalomethanes, and bacterial concentrations in finished water immediately following Hurricane Harvey. Microbial community analyses highlight the dependence of the distribution system microbiota on distribution system characteristics (i.e. water age), raw water quality, and disinfectant residual, among other factors. While both systems had problems maintaining disinfectant residual in the weeks following the hurricane, stabilization of water quality occurred over time. Overall, this study provides an understanding of the challenges associated with maintaining drinking water quality in the wake of a natural disaster and can be used to better prepare drinking water managers and engineers to combat changing weather patterns in the future.
Study on Safety Environment of Highway High Slope Excavation Construction in Civil Engineering
Authors: Wang Haiyan 
Published: November 2019

Abstract
Based on a large number of studies and engineering test, this paper proposes a two-stage evaluation technique for construction safety environment risk assessment of civil engineering slope excavation based on topographic geological conditions and construction environment in civil engineering. In terms of the assignment and practicality of indicators, the basic principles of simple and practical are followed, highlighting the key factors of geological conditions, emphasizing the dynamic supervision of the process, and adopting the height and stability correction coefficient of respecting the empirical model.
Research and prospect on column-column connection of assembled multi-layer steel structure
Authors: Guo D M , Wang Y Q , Yi Y C 
Published: November 2019

AbstractAssembled steel structure residential houses have the significant advantages of light weight, high strength and a high degree of utilization of space, which is an important development direction of the future residential industry for meeting the strategic needs of China’s “four sections –environmental protection”, sustainable development of the construction industry, and the technical requirements of industrialization of housing construction. This paper reviews and summarizes the current status and research progress on the static performance and seismic performance of fabricated multi-story steel column-column connections, including connection types, tests, finite element analysis, etc. These results provide a reference for the further research work and establishing the design methods on column-column connections in the steel structures, as is expected to promote the application of the column-column connections in China’s steel structure engineering.
The application and research progress of steel structures in construction industrialization
Authors: Peng Yi 
Published: November 2019

Abstract
Building industrialization is the trend for future building industry. The development prospect is promising because of the many advantages of fabricated steel structure. This paper presents an introduction to the fabricated steel structures, including its concept, advantage and main forms in domestic and overseas areas. Besides, the latest researches on the fabricated steel structures were reviewed. Typical cases of assembled buildings with steel-structure were also introduced. The questions and difficulties concerning this issue are also discussed in this paper.
Discussion on the Defense Safety Design Strategies of Building’s Outside Environment Base on Rational Choice Theory——Take Changchun as Example
Authors: Wang Keqi , Wang Qi , Liang Baixue 
Published: November 2019

Abstract
The Rational choice theory is widely used as a framework for understanding, explaining and modeling social and economic behavior of individuals. The outside environment of buildings is one of the most important carrier of some kind of crimes. A proper building’s outside environment can minimise the occurrence of crime. The positivity the accessibility and the visibility of space can affect the occurrence of crime. The paper takes the rational choice theory as foundation and analyzes the relationship between building’s outside environment and crime. And some strategies are put forward on how to improve the quality of building’ s outside environment.
Signal processing techniques for structural health monitoring of super high-rise buildings
Authors: Hu Han , Tang Mengxiong , Li Liejun , Hu Hesong , Qiao Shengfang 
Published: November 2019

Abstract
Along with the accelerating urbanization and the increasing population density, large numbers of super high-rise buildings have been built around the world in the past decades. Together with the successive construction of these buildings, the structural safety issues have received more and more attention from all walks of life. During the operation period of super high-rise buildings, the long-term effects of environmental degradation and abnormal loads usually lead to the occurrence of damages in local areas of the building structure, which after long time accumulation, would inevitably cause the degradation of structural performance, or even structural failures, severely threatening life and property to the country and people. Therefore, various structural damage identification techniques are applied to conduct structural health monitoring (SHM) for super high-rise buildings that under construction and completed in order to discover possible structural damages in time, and carry out safety assessments with disaster warnings for possible dangers and unfavorable conditions of the structures for determination of reasonable and economic maintenance periods. This paper gives a brief review on the existing signal processing techniques used for damage identification and SHM of super high-rise buildings, and further summarizes the future research trend of these techniques.
Research overview on public-private partnership (PPP) project supervision in the field of hydraulic engineering
Authors: Song Xue , Li Wan , Tian Mai Jin 
Published: November 2019

Abstract
As the public-private partnership(PPP) model widely used in the field of hydraulic engineering, the PPP project supervision is particularly important. This paper analyzes the current PPP project supervision and regulation, analyzes the PPP project supervision definition and theory, and summarizes the research progress of PPP project supervision in the field of hydraulic engineering from the perspectives of supervision content, supervision issues and supervision methods.On this basis, together with analyzing the present supervision situation and supervision research present situation of the PPP project in the field of our country hydraulic engineering, this paper explores the limitations of existing research results on the PPP project supervision in the field of hydraulic engineering, and puts forward several further researched areas.
Evaluation of safety management responsibility system for highway maintenance
Authors: Lv Jina , Hong Weiwei , Ding Beiyan , Wang Yuanqing 
Published: November 2019

Abstract
In order to evaluate the implementation effect of highway maintenance safety management responsibility system, this paper constructs a performance evaluation index system of highway maintenance safety management responsibility system based on Hall’s three-dimensional structure theory. The system includes three aspects: organizational effect, economic effect and social service effect. We designed a questionnaire consisting of three parts: implementation survey, implementation effect survey and satisfaction survey, and selected the historical dynamic comparison method to evaluate the implementation effect of the system in Shaanxi Province. The results show that after the implementation of the responsibility system of highway maintenance safety management, the indicators of safety management personnel allocation compliance, the clarity of risk source disposal measures and other indicators have been significantly improved, and the number of casualties and responsible accidents has been significantly reduced. “System” has been recognized and supported by the industry. The evaluation index system constructed in this paper can quantitatively evaluate the implementation effect of the responsibility system of highway maintenance safety management, which is of great significance to improve the level of highway maintenance safety management.
Force and deformation mechanism of great pipe shed advanced support in subway tunnel
Authors: Li Lidan , Liu Dengkai , Zhen Yinghong , Liu Zhaoxiang 
Published: November 2019

Abstract
Taking the construction of a certain section of Guiyang rail transit as an example, the theoretical analysis of the stress conditions and constraints of the pipe shed during tunnel excavation is carried out for the support parameters of the large pipe shed. By analyzing the force of the micro-segment of the pipe shed, bringing the Bernoulli-Euler beam theory formula into the equilibrium equation of the micro-segment, the governing differential equations of the pipe shed at the vault and the non-arch is obtained. Two types of pipe sheds are designed, and the numerical simulation of the tunnel with two structural forms of tunnel with advanced support of large pipe shed is carried out by using MIDAS/GTS NX finite element software, and the displacement and stress of the pipe shed are obtained and the theoretical verification is carried out. By comparing the displacement and vertical stress of the large tubular awning in plan 1 and plan 2, it is concluded that plan 2 is more reasonable and has better bearing capacity.
Research on design method of composite arch-cover excavation for super shallow-buried long-span metro station
Authors: Jiang Qichen , Li Kexian , Liu Peng , Wang Zhenjun 
Published: November 2019

Abstract
Arch-cover method is an effective construction method in upper-soft lower-hard strata, but its applicability in large-span excavation is still problematic. Based on a large-span and super-shallow-buried underground station excavation project of Qingdao Metro, a composite arch-cover method featured with double-layer lining and two-lining was proposed. The whole process of arch-cover excavation was simulated by finite difference method FLAC2D, and the evolution law of structural stress and stratum deformation were obtained. The results show that the stress of the arch cover can be evenly distributed by the interaction of the inner and outer lining, and the formation of concentrated stress zone can be avoided. The bearing capacity of arch cover can be improved, and the generation of lining cracks can be effectively reduced. Stress at the skewback of composite arch cover method should be strengthened. The maximum stress and displacement of rock and soil in the upper part of the station cavern should occur in the process of removing the middle pillar and applying the second initial support. Correspondingly, the monitoring frequency should be increased, and the support should be timely processed. This method is reasonable and feasible, and can provide reference for similar projects.
Nonlinear buckling analysis of arch structure to initial defect sensitivity
Authors: Yang Fan , Feng Tao , Xie Yan 
Published: November 2019

Abstract
Due to the more and more prominent nonlinear buckling problems of large-span arch structures in engineering applications, and the lack of special design methods of large-span arch structures in existing specifications, this paper establishes a simplified mechanical model for the stability of arch structures with initial geometric defects. The finite element model of arch structure is established by using finite element software, and the characteristic value buckling analysis and geometric nonlinear analysis are carried out to find out the buckling mode of arch structure, and the sensitivity of defects to arch structure is studied. The results show that the existence of defects will reduce the bearing capacity of the structure, and the increase of defects will change the deformation form of the structure.