bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual migration strategy fidelity but no habitat specialization in two congeneric seabirds
Authors: Merkel Benjamin , Descamps Sébastien , Yoccoz Nigel G. , Grémillet David , Daunt Francis , Erikstad Kjell E. , Ezhov Aleksey V. , Harris Mike P. , Gavrilo Maria , Lorentsen Svein‐Håkon , Reiertsen Tone K. , Steen Harald , Systad Geir H. , Þórarinsson Þorkell Lindberg , Wanless Sarah , Strøm Hallvard 
Published: October 2020

AbstractAimIn migratory species, individuals often use fixed and individual‐specific migration strategies, which we term individual migration strategy fidelity (IMSF). Our goal was to test if guillemots have flexible or fixed individual migration strategies (i.e. IMSF), if this behaviour is consistent across large parts of the genus’ range and if they were philopatric to geographical sites or a habitat feature.LocationNorth Atlantic.TaxonUriaspp.MethodsWe quantified consistent individual differences in inter‐annual spatial distribution and habitat occupied throughout the non‐breeding period using a large geolocator tracking dataset of 729 adult seabirds breeding at 13 colonies across the Northeast Atlantic and repeatedly tracked up to 7 years over a 9‐year period. Additionally, we used a similarity index to calculate relative fidelity to either geographical sites or habitats and linear mixed‐effects models to assess persistence of spatial site fidelity over multiple years.ResultsBoth guillemot species exhibited IMSF across a large part of the genus’ range which persisted over multiple years. Individuals of both species and almost all colonies showed fidelity to geographical sites and not to specific habitats.Main conclusionsGuillemots show IMSF that is best explained by site familiarity (fidelity to specific sites) rather than habitat specialization (fidelity to specific habitats). In the context of rapidly changing environments, favourable habitats may permanently shift locations and hence species displaying IMSF driven by site familiarity—such as the genusUria—may not be able to adjust their migration strategies sufficiently fast to sustain individual fitness and ensure population persistence.
Patient‐reported outcomes and subsequent management in atrial fibrillation clinical practice: Results from the Utah mEVAL AF program
Authors: Zenger Brian , Zhang Mingyuan , Lyons Ann , Bunch T. Jared , Fang James C. , Freedman Roger A. , Navaravong Leenhapong , Piccini Jonathan P. , Ranjan Ravi , Spertus John A. , Stehlik Josef , Turner Jeffrey L. , Greene Tom , Hess Rachel , Steinberg Benjamin A. 
Published: October 2020

AbstractBackgroundAtrial fibrillation (AF) significantly reduces health‐related quality of life (HRQoL), previously measured in clinical trials using patient‐reported outcomes (PROs). We examined AF PROs in clinical practice and their association with subsequent clinical management.MethodsThe Utah My Evaluation (mEVAL) program collects the Toronto AF Symptom Severity Scale (AFSS) in AF outpatients at the University of Utah. Baseline factors associated with worse AF symptom score (range 0–35, higher is worse) were identified in univariate and multivariable analyses. Secondary outcomes included AF burden and AF healthcare utilization. We also compared subsequent clinical management at 6 months between patients with better versus worse AF HRQoL.ResultsOverall, 1338 patients completed the AFSS symptom score, which varied by sex (mean 7.26 for males vs. 10.27 for females; p < .001), age (<65, 9.73; 65–74, 7.66; ≥75, 7.58; p < .001), heart failure (9.39 with HF vs. 7.67 without; p < .001), and prior ablation (7.28 with prior ablation vs. 8.84; p < .001). In multivariable analysis, younger age (mean difference 2.92 for <65 vs. ≥75; p < .001), female sex (mean difference 2.57; p < .001), pulmonary disease (mean difference 1.88; p < .001), and depression (mean difference 2.46; p < .001) were associated with higher scores. At 6‐months, worse baseline symptom score was associated with the use of rhythm control (37.1% vs. 24.5%; p < .001). Similar cofactors and results were associated with increased AF burden and health care utilization scores.ConclusionsAF PROs in clinical practice identify highly‐symptomatic patients, corroborating findings in more controlled, clinical trials. Increased AFSS score correlates with more aggressive clinical management, supporting the utility of disease‐specific PROs guiding clinical practice.
The stiffness‐controlled release of interleukin‐6 by cardiac fibroblasts is dependent on integrin α2β1
Authors: Gałdyszyńska Małgorzata , Bobrowska Justyna , Lekka Małgorzata , Radwańska Paulina , Piera Lucyna , Szymański Jacek , Drobnik Jacek 
Published: October 2020

AbstractCardiac fibroblasts are able to sense the rigidity of their environment. The present study examines whether the stiffness of the substrate in cardiac fibroblast culture can influence the release of interleukin‐6 (IL‐6), interleukin‐11 (IL‐11) and soluble receptor of IL‐6 (sIL‐6R). It also examines the roles of integrin α2β1 activation and intracellular signalling in these processes. Cardiac fibroblasts were cultured on polyacrylamide gels and grafted to collagen, with an elasticity of E = 2.23 ± 0.8 kPa (soft gel) and E = 8.28 ± 1.06 kPa (stiff gel, measured by Atomic Force Microscope). Flow cytometry and ELISA demonstrated that the fibroblasts cultured on the soft gel demonstrated higher expression of the α2 integrin subunit and increased α2β1 integrin count and released higher levels of IL‐6 and sIL‐6R than those on the stiff gel. Substrate elasticity did not modify fibroblast IL‐11 content. The silencing of the α2 integrin subunit decreased the release of IL‐6. Similar effects were induced by TC‐I 15 (an α2β1 integrin inhibitor). The IL‐6 levels in the serum and heart were markedly lower in α2 integrin‐deficient mice B6.Cg‐Itga2tm1.1Tkun/tm1.1Tkun than wild type. Inhibition of Src kinase by AZM 475271 modifies the IL‐6 level. sIL‐6R secretion is not dependent on α2β1 integrin. Conclusion: The elastic properties of the substrate influence the release of IL‐6 by cardiac fibroblasts, and this effect is dependent on α2β1 integrin and kinase Src activation.
Description of two new miniature species of Hylopanchax Poll & Lambert, 1965 (Cyprinodontiformes: Procatopodidae), from northeastern Gabon, with an updated diagnosis of the genus based on morphology, colouration and osteology
Authors: Bragança Pedro H. N. , van der Zee Jouke R. , Sonnenberg Rainer , Vreven Emmanuel J. W. M. N. 
Published: October 2020

AbstractTwo new species of the lampeye genus Hylopanchax are described from the Ivindo River basin in the Ogowe River drainage. Hylopanchax multisquamatus, new species, and Hylopanchax thysi, new species, differ from congeners by the presence of a hyaline urogenital male papilla with small black spots and a dark‐brown reticulate pattern on the flanks of both males and females in preserved specimens. Hylopanchax multisquamatus is distinguished from congeners by the number of scales on the mid‐longitudinal series (27–30 vs. 19–26, respectively) and by the relative anterior/posterior flank scale depth ratio (140%–150% vs. 170%–220%). Hylopanchax thysi is distinguished from all other congeners, except Hylopanchax paucisquamatus, by the presence of vertebrae (30 vs. 31–33) and is further distinguished from H. multisquamatus by the presence of a deeper caudal peduncle and much larger anterior flank scales. It is distinguished from H. paucisquamatus by the presence of a hyaline urogenital male papilla with small black spots and a dark‐brown reticulate pattern on the flanks of both males and females in preserved specimens. Osteological data of Hylopanchax are presented for the first time, and an updated diagnosis based on external morphology, colouration pattern and osteology is provided. An osteological comparison with closely related species belonging to the genera Procatopus, Hypsopanchax and “Hypsopanchax” is presented. (a) A truncate and slightly downward‐directed anterior process of the angulo‐articular and (b) a guitar‐shaped lachrymal with both its anterior and posterior margins sharply curved are here considered as diagnostic features of Hylopanchax.
Pre‐ampullary location and size ≥10 mm are independent predictors for high‐grade superficial non‐ampullary duodenal epithelial tumors
Authors: Matsueda Katsunori , Uedo Noriya , Kitamura Masanori , Iwagami Hiroyoshi , Shichijo Satoki , Maekawa Akira , Kanesaka Takashi , Takeuchi Yoji , Higashino Koji , Ishihara Ryu 
Published: October 2020

AbstractBackground and AimThe incidence of identified superficial non‐ampullary duodenal epithelial tumors (SNADETs) has been increasing with recent advances in endoscopic diagnosis. Nevertheless, the clinical features of SNADETs with malignant potential remain unclear. The aim of the present study was to clarify the clinical characteristics of high‐grade SNADETs.MethodsA total of 328 SNADETs that had been endoscopically or surgically resected between January 2013 and April 2019 were identified from an endoscopic and pathological database. Clinical characteristics were compared between mucosal low‐grade neoplasm (n = 154) and mucosal high‐grade neoplasm/submucosal carcinoma (HGN/SMC, n = 174).ResultsIn univariate analysis, tumor size, pre‐ampullary tumor location, red color, and rough/nodular surface were significantly associated with HGN/SMC. In multivariate analysis (odds ratio [95% confidence interval]), large (≥10 mm) tumor size (odds ratio: 4.5, 95% confidence interval: 2.6–7.7, P < 0.001) and pre‐ampullary tumor location (odds ratio: 2.1, 95% confidence interval: 1.3–3.5, P = 0.004) were independent predictors for HGN/SMC. Analysis of histological phenotypes revealed that the proportion of tumors that were HGN/SMC was much greater for gastric‐type tumors (21/23 lesions, 91%) than for intestinal‐type tumors (150/302 lesions, 50%) (P < 0.001) and that all gastric‐type tumors were located in the pre‐ampullary portion.ConclusionsPre‐ampullary location and large tumor size are independent predictors for HGN/SMC SNADETs. Pre‐ampullary tumor location is significantly associated with gastric histological phenotype. These findings may help in decision making for endoscopic treatment, active indication for pre‐ampullary tumor or tumor ≥10 mm, and understanding the pathophysiology of SNADETs.
Reducing Hospital Transfers from Aged Care Facilities: A Large‐Scale Stepped Wedge Evaluation
Authors: Hullick Carolyn J. , Hall Alix E. , Conway Jane F. , Hewitt Jacqueline M. , Darcy Leigh F. , Barker Roslyn T. , Oldmeadow Christopher , Attia John R. 
Published: October 2020

BACKGROUND/OBJECTIVESOlder people living in residential aged care facilities (RACFs) experience acute deterioration requiring assessment and decision making. We evaluated the impact of a large‐scale regional Aged Care Emergency (ACE) program in reducing hospital admissions and emergency department (ED) transfers.DESIGNA stepped wedge nonrandomized cluster trial with 11 steps, implemented from May 2013 to August 2016.SETTINGA large regional and rural area of northern and western New South Wales, Australia.PARTICIPANTSNine hospital EDs and 81 RACFs participated in the evaluation.INTERVENTIONThe ACE program is an integrated nurse‐led intervention underpinned by a community of practice designed to improve the capability of RACFs managing acutely unwell residents. It includes telephone support, evidence‐based algorithms, defining goals of care for ED transfer, case management in the ED, and an education program.MEASUREMENTSED transfers and subsequent hospital admissions were collected from administrative data including 13 months baseline and 9 months follow‐up.RESULTSA total of 18,837 eligible ED visits were analyzed. After accounting for clustering by RACFs and adjusting for time of the year as well as RACF characteristics, a statistically significant reduction in hospital admissions (adjusted incident rate ratio = .79; 95% confidence interval [CI] = .68–.92); P = .0025) was seen (i.e., residents were 21% less likely to be admitted to the hospital). This was also observed in ED visit rates (adjusted incidence rate ratio = .80; 95% CI = .69–.92; P = .0023) (i.e., residents were 20% less likely to be transferred to the ED). Seven‐day ED re‐presentation fell from 5.7% to 4.9%, and 30‐day hospital readmissions fell from 12% to 10%.CONCLUSIONThe stepped wedge design allowed rigorous evaluation of a real‐world large‐scale intervention. These results confirm that the ACE program can be scaled up to a large geographic area and can reduce ED visits and hospitalization of older people with complex healthcare needs living in RACFs.
“Los chinos no beben vino”: Mercados, intermediarios y valor del vino argentino en China
Authors: Badaró Máximo 
Published: October 2020

ResumenEn este artículo analizo las relaciones comerciales entre América Latina y China desde la perspectiva de los intermediarios comerciales argentinos, europeos y chinos que promocionan vinos argentinos en China. En la última década, China se convirtió en uno de los mercados de consumo de vino importado de mayor crecimiento global y en un destino deseado por los intermediarios comerciales y las empresas extranjeras que buscan vender sus productos en este mercado, como es el caso de muchas bodegas argentinas. A partir de un estudio etnográfico que realicé en Shanghái en 2018, analizo las modalidades de atribución de valor que estos profesionales utilizan para la promoción de sus vinos en China. Sostengo que sus principales desafíos giran en torno a la construcción del valor relacional del vino argentino en China —esto es, el rol que cumple el vino en las relaciones sociales en este país.
Metamorphic evolution and SIMS U–Pb geochronology of orthopyroxene‐bearing high‐Psemipelitic granulite in the Fuping area, middle Trans‐North China Orogen
Authors: Liu Jia‐Hui , Zhang Qian W. L. , Wang Juan , Zhang Hui C. G. , Wu Chun‐Ming 
Published: October 2020

AbstractThe Fuping area lies in the middle part of the Trans‐North China Orogen, which is a critical region for understanding the metamorphic–tectonic evolution of this orogenic belt in the Precambrian. The newly discovered orthopyroxene‐bearing semipelitic granulite in this area is a coherent stratigraphic unit, among which three generations of metamorphic mineral assemblages (peak, post‐peak and cooling retrograde) have been identified based on petrographic observation and mineral chemical analysis. The peak metamorphic mineral assemblage mainly consists of porphyroblastic garnet plus matrix minerals including biotite, plagioclase, orthopyroxene, quartz as well as accessory minerals including pyrite, monazite, zircon and apatite. Geothermobarometry calculations and phase equilibria modelling confirm that the representative samples record differentP–Tconditions and metamorphic stages due to retrogressive metamorphism, with the highestP–Tconditions reaching high‐Pgranulite facies. The retrieved clockwise metamorphicP–Tpaths pass from 12.5 to 13.5 kbar/855–880℃ (peak stage) through 8.5–11 kbar/850–886℃ (post‐peak stage) and to a speculative cooling phase (retrograde stage), reflecting near isothermal decompression (ITD) followed by near isobaric cooling (IBC). ThisP–Tpath is interpreted to reflect a subduction and/or collision event followed by a rapid exhumation. Secondary ion mass spectrometry (SIMS) U–Pb dating on metamorphic monazite and zircon yielded metamorphic ages ranging from 1,825 to 1,815 Ma, possibly constraining a retrograde metamorphic age. Therefore, the semipelitic granulite in the Fuping area records the subduction/collision event between the Eastern and Western Blocks of the North China Craton during the Late Palaeoproterozoic.
The patient perspective of nurse‐led care in early rheumatoid arthritis: A systematic review of qualitative studies with thematic analysis
Authors: Sweeney Anne‐Marie Tetsche , McCabe Candy , Flurey Caroline A , Robson Joanna C , Berry Alice , Richards Pamela , Ndosi Mwidimi 
Published: October 2020

AbstractIntroductionManagement of rheumatoid arthritis has changed dramatically over the last decade and is characterised by early start of intensive treatment and tight monitoring of disease activity until remission. The role of nurse‐led care at early stage of disease is not well understood.AimsTo develop an understanding of rheumatology nurse‐led care from the perspective of patients with early rheumatoid arthritis.MethodsA systematic review of qualitative studies, reported in line with PRISMA checklist. In March 2019, the following databases were searched: MEDLINE, EMBASE, CINAHL, PsycINFO and OpenGrey. Studies were included if they: included adults with rheumatoid arthritis; were qualitative studies with data on patients’ perspectives of nurse‐led care; and published in peer‐reviewed journals, in English, between 2010–2019. Due to few studies in early rheumatoid arthritis, inclusion was extended to adults with established rheumatoid arthritis. Two reviewers screened abstracts and full texts. Joanna Briggs Institute Critical Appraisal Tool was used for quality assessment. Thematic synthesis was conducted according to the framework of Thomas and Harden (2008).ResultsThe search identified 1034 records. After screening and assessing for eligibility, eight qualitative studies were included in the review (133 patients). Three themes were identified from the synthesis. Nurse‐led care was seen to provide professional expertise in planning and delivery of care. A person‐centred approach was used combined with good communication skills, thus creating a positive therapeutic environment. Nurse‐led care was described as providing a sense of empowerment and psychological support.ConclusionPatients with rheumatoid arthritis are supportive of nurse‐led care. They value its professionalism and person‐centred approach which provide a sense of security and confidence.Relevance to Clinical PracticeThe findings outline ingredients of nurse‐led care that are important to patients. These can inform nurses’ professional development plans, service improvement and the competence framework for rheumatology nursing.
Pediatric nurse practitioners' attitudes/beliefs and knowledge/perceived competence in caring for transgender and gender‐nonconforming youth
Authors: Collins Cathleen A. 
Published: October 2020

AbstractPurposeThere is a growing number of youth and their parents seeking assistance from care providers related to gender dysphoria and transitional care for transgender and gender‐nonconforming (TGNC) youth. The purpose of this study was to determine pediatric nurse practitioners’ (PNP) attitudes/beliefs and knowledge/competence in caring for TGNC youth.Design and MethodsThis cross‐sectional descriptive study surveyed PNPs (N = 93) from eight states using two survey instruments to measure attitudes and beliefs and knowledge and perceived competence related to caring for TGNC youth.ResultsEighty‐one percent of PNPs reported caring for TGNC youth in their practice. Despite this, only 15% of the PNPs received education related to transgender patients during their advanced practice education. Results showed that attending continuing education offerings related to caring for TGNC patients increases PNP perceived competence as well as knowledge. Attitudes and behaviors towards the transgender population were also more positive if the PNP had attended continuing nursing education offerings. Three themes emerged from a qualitative portion of the survey, asking the participant to share thoughts related to caring for transgender youth: lack of education for healthcare providers, the need to refer patients to comprehensive gender services, and the need for support for transgender patients and their families.Practice ImplicationsEducation plays an important part in nurses’ attitudes, beliefs, and perceived competence in caring for transgender patients. Because the PNP is likely to be exposed to patients with TGNC, it is imperative they seek out opportunities to learn about transgender issues and caring for transgender patients.
Associations between objective afternoon and evening physical activity and objective sleep in patients with fibromyalgia and insomnia
Authors: McGovney Kevin D. , Curtis Ashley F. , McCrae Christina S. 
Published: October 2020

AbstractPatients with fibromyalgia (FM) suffer from chronic pain, which limits physical activity and is associated with disturbed sleep. However, the relationship between physical activity, pain and sleep is unclear in these patients. This study examined whether actigraphic (Actiwatch‐2, Philips Respironics) afternoon and evening activity and pain are associated with actigraphic sleep. Adults with FM and insomnia complaints (n = 160, mean age [Mage] = 52, SD = 12, 94% female) completed 14 days of actigraphy. Activity levels (i.e., activity counts per minute) were recorded, and average afternoon/evening activity for intervals 12:00–3:00 PM, 3:00–6:00 PM and 6:00–9:00 PM was computed. Multiple linear regressions examined whether afternoon/evening activity, pain (daily evening diaries from 0 [no pain sensation] to 100 [most intense pain imaginable]), or their interaction, predicted sleep onset latency (SOL), wake time after sleep onset (WASO), total sleep time (TST) and sleep efficiency (SE). Greater afternoon activity was independently associated with lower SE (B = −0.08, p < .001), lower TST (β = −0.36, standard error [SE] = 0.06, p < .001) and longer WASO (B = 0.34, p < .001). Greater early evening activity was independently associated with lower SE (B = −0.06, p < .001), lower TST (β = −0.26, SE = 0.06, p < .001) and longer WASO (B = 0.23, p < .001). Self‐reported pain intensity interacted with afternoon and early evening physical activity, such that associations between higher activity and lower SE were stronger for individuals reporting higher pain. Late evening activity was not associated with sleep outcomes. Results suggest that in FM, increased afternoon and early evening physical activity is associated with sleep disturbance, and this relationship is stronger in individuals with higher pain.
Hemorrhage and complications associated with percutaneous ultrasound guided liver biopsy in dogs
Authors: Reece Jonjo , Pavlick Michelle , Penninck Dominique G. , Webster Cynthia R. L. 
Published: October 2020

AbstractBackgroundLiver biopsy is often necessary to obtain a diagnosis in dogs with hepatobiliary disease. Hemorrhage after biopsy is a concern.ObjectiveTo describe the extent of hemorrhage and incidence of complications after percutaneous ultrasound guided liver biopsy (PUGLB) in dogs and to examine risk factors for hemorrhage or complications.AnimalsOne hundred two client owned dogs with suspected hepatobiliary disease that underwent PUGLB.MethodsMedical records were retrospectively reviewed. Using human guidelines, major hemorrhage was defined as an absolute decrease in the PCV (ΔPCV)≥6%. Complications were defined separately as clinically relevant physiologic compromise that necessitated intervention or death. The relationship between ΔPCV and the occurrence of complications and the initial PCV, coagulation variables, serum activity of liver‐derived enzymes, serum bilirubin concentration, number of biopsies, biopsy needle gauge, radiologist experience, histological diagnosis, and ultrasound variables were compared.ResultsBefore PUGLB, most aberrations in coagulation variables were mild. After biopsy a decrease in PCV occurred in 87/102 (85.3%) dogs. The mean ΔPCV was −7.2% ± 4.5%. Major hemorrhage occurred in 43/102 (42.2%) dogs and complications in 2/102 (1.9%). ΔPCV was significantly positively correlated with PCV before biopsy (r= .47,P= .004). There was no correlation between ΔPCV or complications with any of the variables examined.Conclusion and Clinical ImportancePercutaneous ultrasound guided liver biopsy in the population of dogs in the current study, with normal or mild abnormalities in coagulation, results in a high incidence of clinically silent, major hemorrhage (42.5%), but few complications (1.9%).