bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diligent profiling of preclinical safety of the silk protein sericin
Authors: Ahsan Farogh , Mahmood Tarique , Siddiqui Mohammed Haris , Usmani Shazia , Bagga Paramdeep , Shamim Arshiya , Srivastav Ritesh Kumar 
Published: March 2020

Abstract

Background
Sericin is a widely used protein in the pharmaceutical industry derived from the silkworm, Bombyx mori, and used for the treatment of various diseases and pathological conditions. It is the main ingredient of the Unani preparation khameera abresham. The study was conducted to evaluate the preclinical toxicity of the silk protein sericin in mice.

Methods
In the acute toxicity study, sericin was administered once orally to different groups of animals at doses of 500, 1000, and 2000 mg/kg. Animals were observed for 14 days. In the sub-acute toxicity study, sericin was administered in mice for 4 weeks in the toxic group at doses of 500, 1000, and 2000 mg/kg, while in the recovery group it was administered for 4 weeks at doses of 500 and 2000 mg/kg followed by 2 weeks of distilled water administration.

Results
In the acute toxicity study, the observed parameters showed no significant difference, and no mortality was reported. In the sub-acute toxicity study, there were no toxicological effects in any of the estimated parameters, while histopathological analysis showed inflammation in vital organs at the dose of 2000 mg/kg.

Conclusions
Results of our acute toxicity study suggest that sericin is safe at all administered doses, while the sub-acute study suggests that the NOAEL (no-observed-adverse-effect level) of sericin is below 2000 mg/kg, at which it can be considered safe.
Transcendental Idealism and the Self-Knowledge Premise
Authors: Tse Chiu Yui Plato 
Published: March 2020

AbstractThe relation between transcendental idealism and philosophical naturalism awaits more careful determination, i. e. whether the issue of their compatibility hinges on their ontological view on the relation between physical and mental phenomena (i. e. whether it is supervenience or emergence) or on their epistemological view on our access to mental content. The aim of this paper is to identify a tension between transcendental idealism and philosophical naturalism, which lies not in their ontological view on the nature of substances, but in their epistemological view on the relation between self-awareness and the first-personal access to mental content. I will first trace the (mis)understanding of transcendental idealism as Berkeleyan idealism to a misinterpretation of the self-knowledge premise in transcendental arguments. I will argue that transcendental idealism is not so much concerned with grounding reality of the external world as with establishing the agential nature of the first-personal perspective of experience, and it has an important implication on the meaning and function of self-awareness in transcendental idealism.
Rule-governed Practices in the Natural World
Authors: Huemer Wolfgang 
Published: March 2020

AbstractI address the question of whether naturalism can provide adequate means for the scientific study of rules and rule-following behavior. As the term “naturalism” is used in many different ways in the contemporary debate, I will first spell out which version of naturalism I am targeting. Then I will recall a classical argument against naturalism in a version presented by Husserl. In the main part of the paper, I will sketch a conception of rule-following behavior that is influenced by Sellars and Haugeland. I will argue that rule-following is an essential part of human nature and insist in the social dimension of rules. Moreover, I will focus on the often overlooked fact that genuine rule-following behavior requires resilience and presupposes an inclination to calibrate one’s own behavior to that of the other members of the community. Rule-following, I will argue, is possible only for social creatures who follow shared rules, which in turn presupposes a shared (first-person plural) perspective. This implies, however, that our scientific understanding of human nature has to remain incomplete as long as it does not take this perspective, which prima facie seems alien to it, into account.
Plasma matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 as prognostic biomarkers in critically ill patients
Authors: Duda Izabela , Krzych Łukasz , Jędrzejowska-Szypułka Halina , Lewin-Kowalik Joana 
Published: March 2020

Abstract
Matrix metalloproteinase 9 (MMP-9) plays an important role in inflammatory and pathological processes by enabling the inflow of leukocytes to the site of infection or tissue damage. MMP-9 and tissue inhibitor of metalloproteinase 1 (TIMP-1) have been described as potential prognostic biomarkers in various clinical settings. The aim of the study was to evaluate the usefulness of plasma levels of MMP-9 and TIMP-1 as well as the MMP-9/ TIMP-1 ratio in predicting the outcome in patients admitted to the intensive care unit (ICU). The study included 56 critically ill patients with multiple organ failure. Plasma levels of MMP-9 and TIMP-1 were determined on hospitalization day 1, 2, 3 and 7. Nineteen (35.7%) patients died. The level of TIMP-1 was statistically significantly higher on day 1 and 7 of hospitalization in non-survivors, as compared to survivors (p=0.01). A statistically significant positive correlation was found between MMP-9 and TIMP-1. The MMP-9/TIMP-1 ratio was comparable in both groups during of observation (0.62 on day 1). The MMP-9/TIMP-1 ratio was positively correlated with the level of lactate and negatively correlated with platelet count. Likewise, TIMP-1 was positively correlated with the level of lactate. The level of MMP-9 was higher in the non-survivor group only on day 7 of observation. In conclusion, although TIMP-1 and MMP-9 concentrations were higher in non-survivors and the MMP-9/TIMP-1 ratio was related to some parameters of critical illness, further research is needed to verify whether they can serve as reliable biomarkers for early prognostication of ICU patients.
On uniformly fully inert subgroups of abelian groups
Authors: Dardano Ulderico , Dikranjan Dikran , Salce Luigi 
Published: March 2020

AbstractIf H is a subgroup of an abelian group G and φ ∈ End(G), H is called φ-inert (and φ is H-inertial) if φ(H) ∩ H has finite index in the image φ(H). The notion of φ-inert subgroup arose and was investigated in a relevant way in the study of the so called intrinsic entropy of an endomorphism φ, while inertial endo-morphisms (these are endomorphisms that are H-inertial for every subgroup H) were intensively studied by Rinauro and the first named author.A subgroup H of an abelian group G is said to be fully inert if it is φ-inert for every φ ∈ End(G). This property, inspired by the “dual” notion of inertial endomorphism, has been deeply investigated for many different types of groups G. It has been proved that in some cases all fully inert subgroups of an abelian group G are commensurable with a fully invariant subgroup of G (e.g., when G is free or a direct sum of cyclic p-groups). One can strengthen the notion of fully inert subgroup by defining H to be uniformly fully inert if there exists a positive integer n such that |(H + φH)/H| ≤ n for every φ ∈ End(G). The aim of this paper is to study the uniformly fully inert subgroups of abelian groups. A natural question arising in this investigation is whether such a subgroup is commensurable with a fully invariant subgroup. This paper provides a positive answer to this question for groups belonging to several classes of abelian groups.
A MOF based on a lead(II) 2-oxido-6-methylpyridine-4-carboxylate network
Authors: Tang Long , Fu Yu Pei , Cui Na , Wang Ji Jiang , Hou Xiang Yang , Wang Xiao 
Published: March 2020

Abstract
A new metal-organic framework, [Pb(hmpcaH)2]
n
(1), has been hydrothermally synthesized from Pb(OAc)2 · 3H2O and 2-hydroxy-6-methylpyridine-4-carboxylic acid (hmpcaH2; 2), and characterized by IR spectroscopy, elemental and thermogravimetric analysis, and single-crystal X-ray diffraction. In complex 1, each hmpcaH− ligand represents a three-connected node to combine with the hexacoordinated Pb(II) ions, generating a 3D binodal (3,6)-connected ant network. The crystal structure of 2 was determined. The solid-state fluorescence properties of 1 and 2 were investigated.
Resolving the Spatial Profile of Figure Enhancement in Human V1 through Population Receptive Field Modeling
Authors: Poltoratski Sonia , Tong Frank 
Published: March 2020

The detection and segmentation of meaningful figures from their background is one of the primary functions of vision. While work in nonhuman primates has implicated early visual mechanisms in this figure–ground modulation, neuroimaging in humans has instead largely ascribed the processing of figures and objects to higher stages of the visual hierarchy. Here, we used high-field fMRI at 7 Tesla to measure BOLD responses to task-irrelevant orientation-defined figures in human early visual cortex (N= 6, four females). We used a novel population receptive field mapping-based approach to resolve the spatial profiles of two constituent mechanisms of figure–ground modulation: a local boundary response, and a further enhancement spanning the full extent of the figure region that is driven by global differences in features. Reconstructing the distinct spatial profiles of these effects reveals that figure enhancement modulates responses in human early visual cortex in a manner consistent with a mechanism of automatic, contextually driven feedback from higher visual areas.SIGNIFICANCE STATEMENTA core function of the visual system is to parse complex 2D input into meaningful figures. We do so constantly and seamlessly, both by processing information about visible edges and by analyzing large-scale differences between figure and background. While influential neurophysiology work has characterized an intriguing mechanism that enhances V1 responses to perceptual figures, we have a poor understanding of how the early visual system contributes to figure–ground processing in humans. Here, we use advanced computational analysis methods and high-field human fMRI data to resolve the distinct spatial profiles of local edge and global figure enhancement in the early visual system (V1 and LGN); the latter is distinct and consistent with a mechanism of automatic, stimulus-driven feedback from higher-level visual areas.
New records of ring nematodes, <i>Bakernema enormese</i> n. sp. and <i>Criconema</i> (<i>Nothocriconemella</i>) <i>graminicola</i> Loof, Wouts & Yeates, 1997 (Nematoda: Criconematidae) from natural forests of Vietnam
Authors: Chau Nguyen Ngoc 
Published: March 2020

Bakernema enormese sp. n., collected from rhizosphere of forest wood trees in Muong Phang, Dien Bien Province (north Vietnam) is described and illustrated. The new species is characterized by large body size and stylet. In general, this new species is close to two existing species of the same genus, B. inaequale and B. dauniense by cuticle structure in transparent membranous projections which appear in lateral view as spine-like structures on each annulus. These structure arranged into several rows along the body. In morphology, the new species differs from B. inaequale and B. dauniense by body and stylet length, i.e. 609–842 µm and 143.5–150 µm vs. 391–578 µm and 59–74 µm for B. inaequale and vs. 391–461 µm and 65–74 µm for B. dauniense. In addition, new species can be distinguished from B. inaequale by the longer membranous projection, 8–12 vs. 6–10 µm and vagina shape, curved vs. sigmoid. From B. dauniense, the new species differs by the much longer membranous projection, 8–12 vs. 1.4–2.2 µm and less number annules between vulva and tail end (RV), 3–4 vs. 7.8 annules. The presence of Criconema (Nothocriconemella) graminicola Loof, Wouts & Yeates, in Vietnam with morphometrics, illustrators and remarks given.
Personal Branding in Online Platform
Authors: Shaker Fahim , Hafiz Reaz 
Published: March 2020

Online personal branding connotes a way to communicate favorable attributes of an individual self in the online platform in order to differentiate oneself from others that will assist to attain the professional goals along with relational aspirations. Numerous studies focused on the importance of having a strong personal brand but mostly ignored the way of developing it in the virtual world. The objective of the paper is to explore various literatures from different disciplines to address the issue of developing a contextual framework of “construction of online personal brands.” The study covers the area of personality dimensions, personal brand identity both core and extended, influence of surroundings in identity creation in the online environment, individual’s image positioning and management etc. JEL Classification Code: M31; M37
The Potentiality of Women Entrepreneurs in Bangladesh with Special Reference to Sylhet Region
Authors: Chowdhury Sakufa , Rahman Md. Mizanur 
Published: March 2020

This paper justifies the potentiality of the women entrepreneurs in Bangladesh. For this purpose, Sylhet is taken as a study area which can be the prospective sectors for the women entrepreneurs. Huge amount of foreign remittance comes here from abroad that can be utilized in this sector successfully, and the mindset of people are not so fundamental. All of these issues are supporting to work in this region. Besides these, studying in this sector it is found that the women entrepreneurs of this region are more industrious, self-confident, dynamic, ambitious, adaptable and possess risk taking capacity and last but not the least are creative and innovative. It is obviously profitable sector which is clear after analyzing the data. Attempts also have been made here to find out the characteristics and the contributions of the women entrepreneurs to prove themselves not only as the emerging tigers but also as the economically empowered, solvent, respected and above all a contributor in the national income in this third world country, the obstacles they are facing and also the probable solutions in this context.
JEL Classification Code: M100, M130
Influence of posterior tibial slope on knee flexion in posterior stabilized fixed bearing primary total knee arthroplasty
Authors: Kanugula Sandeep Kumar , Rathod Mallesh , S. M. Venugopal , Lebaku Mohan Babu 
Published: March 2020

<p class="abstract"><strong>Background:</strong> The goal of total knee arthroplasty (TKA) is to relieve pain and maintain stable range of motion (ROM) for day to day activities. Among the various factors, posterior tibial slope slope (PTS) may play an important role in achieving good postoperative knee flexion. Our study aims to know the effectiveness of PTS on the ROM of the knee in a posterior cruciate ligament (PCL)-substituting TKA.</p><p class="abstract"><strong>Methods:</strong> A total of 125 unilateral PCL-substituting TKA’s were included in the study. Based on postoperative PTA which was measured on lateral radiograph, patients were divided into 3 groups, Group A (PTS of ≤2) comprise of 24 patients. Group B consists of 91 patients (PTS of 3 to 7). Group C includes 10 patients (PTS of 8 or more). Functional outcome was measured by using knee society score (KSS) and Western Ontario and McMaster Universities osteoarthritis index (WOMAC) which were evaluated preoperatively and at 18months post operatively.<strong></strong></p><p class="abstract"><strong>Results:</strong> Mean postop ROM was 92.91 ± 10.632; 107.24±10.905; 107.49±13.944 in group A, B, C respectively which was significantly related to mean postop PTS (0.74; 5.62; 9.87 in group A, B, C respectively) (P&lt;0.05). Functional outcome was measured by KSS and WOMAC which showed no significant difference pre and postoperatively.</p><p class="abstract"><strong>Conclusions:</strong> The results of our study validate the hypothesis that a positive correlation exists between the postoperative flexion and PTS in the PCL-substituting TKA, an increase in PTS can lead to a greater degree of the knee flexion for every extra degree of PTS.</p><p> </p>
Responses to Racism within Black Families in Cartagena de Indias
Authors: Villarreal Kristell Andrea , Marrugo Monterrosa Heiver , Ríos Fernández Javier , Ochoa Ramos Ana Cecilia 
Published: March 2020

This article describes some of the responses to everyday racism that occurs within some black families from Cartagena. The categories of analysis of this work were established from the forms of everyday racism conceptualized by Philomena Essed (1991). The data used were obtained through twenty semi-structured interviews. We worked with people who recognize themselves as black, the practices they described took place within the family nucleus where they were formed, but also the family nucleus that they formed during their adulthood.
It is concluded that in many black families from Cartagena are spaces where identity is managed and where the pillars are built, so that subjects can acquire tools that allow them to improve their capacity for social mobility, but it is also a space where racist ideologies can be (re)produced under a protectionist and paternalistic premise.
Poderes autorizados por notarios extranjeros y compraventa de inmuebles situados en España = Power of attorney authorized by foreign notaries and purchase of property located in Spain
Authors: Calvo Caravaca Alfonso-Luis , Carrascosa González Javier 
Published: March 2020

Resumen: El presente estudio muestra que un poder otorgado en país extranjero y empleado para vender o adquirir inmuebles situados en España mediante escritura publica notarial española que posteriormente se presenta para su inscripción en el Registro de la propiedad, debe haber sido otorgado ante notario extranjero que desarrolla funciones similares a las que son propias de los notarios españoles. El art. 10.1 CC es el precepto que impone la necesidad de que el poder se otorgue en documento público equivalente al español. El art. 10.11 CC no incide en dicha cuestión. Tampoco el art. 11.2 CC es aplicable a la cuestión, pues en Derecho español el poder no es un acto jurídico sujeto a forma solemne. Este trabajo también pone de relieve que el notario español debe realizar un juicio de “suficiencia del poder” en el que se encuentra implícito un juicio de “equivalencia de funciones”. Palabras clave: poder otorgado en país extranjero, inmuebles situados en España, notario extranjero, derechos reales.Abstract: This study deals with some issues concerning the legal effects in Spain of a power of attorney granted specially when its is used to sell or acquire real estate located in Spain before a Spanish notary with the purpose of a subsequent registration in the Spanish Property Registry. Art. 10.1 of the Spanish civil code proves that Spanish Law applies to the extent that the foreign notary must have been acted as a Spanish notary would have been when a power of attorney is granted. The requirement of a public document does not derive from Art. 11.2 of the Spanish civil code neither from art. 10.11 of the Spanish civil code. Under Spanish Law, the power of attorney is not a legal act subject to solemn form. This work also highlights that the Spanish notaries must value the adequacy of the power of attorney with regard to the sale of real estate located in Spain.Keywords: power of attorney in a foreign country, real estate located in Spain, foreign notary public, rights in rem.
Assessment of Production Interference Level Due to Fracture Hits Using Diagnostic Charts
Authors: Yang Xi , Yu Wei , Wu Kan , Weijermars Ruud 
Published: March 2020

Summary
The objective of this study is to develop a new method that leads to diagnostic charts that quantify the pressure response between two interfering wells. Analytical linear flow models for single hydraulic fracture are used to develop a fracture hit model, which is next verified with a numerical model for validity. An analytical two-fracture model is then developed to simulate flowing bottomhole pressure (BHP) of a shut-in well, which interferes with the other well through a fracture hit, during well-testing for a short-term period. From the insight of two-fracture analytical model, a dimensionless pressure scalar, which is proportional to square root of time, is proposed to summarize the interference level between two wells. Utilizing such proportionality between the defined dimensionless pressure scalar and square root of time, a diagnostic chart for quick assessment of the production interference level between wells is developed. Such diagnostic chart is also applied to interference caused by multifracture hits that a multistage fractured horizontal well with history match performed from the Eagle Ford formation is considered as a parent well for production interference quantification. A new identical horizontal well, which is just fractured but is not in production, is assumed parallel to the pre-existing well. The result shows that when the percentage of fracture connection increases, the slope of dimensionless pressure scalar vs. square root of time increases proportionally to the percentage of fracture connection. Because the slope of dimensionless pressure scalar vs. square root of time is between 0 and 1, it can be used to quantify the well production interference level under different situations.
Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle
Authors: An Bingxing , Xu Lei , Xia Jiangwei , Wang Xiaoqiao , Miao Jian , Chang Tianpeng , Song Meihua , Ni JunQing , Xu Lingyang , Zhang Lupei , Li Junya , Gao Huijiang 
Published: March 2020

Abstract
Background: Body size traits as one of the main breeding selection criteria was widely used to monitor cattle growth and to evaluate the selection response. In this study, body size was defined as body height (BH), body length (BL), hip height (HH), heart size (HS), abdominal size (AS), and cannon bone size (CS). We performed genome-wide association studies (GWAS) of these traits over the course of three growth stages (6, 12 and 18 months after birth) using three statistical models, single-trait GWAS, multi-trait GWAS and LONG-GWAS. The Illumina Bovine HD 770K BeadChip was used to identify genomic single nucleotide polymorphisms (SNPs) in 1217 individuals.
Results: In total, 19, 29, and 10 significant SNPs were identified by the three models, respectively. Among these, 21 genes were promising candidate genes, including SOX2, SNRPD1, RASGEF1B, EFNA5, PTBP1, SNX9, SV2C, PKDCC, SYNDIG1, AKR1E2, and PRIM2 identified by single-trait analysis; SLC37A1, LAP3, PCDH7, MANEA, and LHCGR identified by multi-trait analysis; and P2RY1, MPZL1, LINGO2, CMIP, and WSCD1 identified by LONG-GWAS.
Conclusions: Multiple association analysis was performed for six growth traits at each growth stage. These findings offer valuable insights for the further investigation of potential genetic mechanism of growth traits in Simmental beef cattle.