bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracellular Group AStreptococcusinduces Golgi fragmentation to impair host defenses through Streptolysin O and NAD-glycohydrolase
Authors: Nozawa Takashi , Iibushi Junpei , Toh Hirotaka , Minowa-Nozawa Atsuko , Murase Kazunori , Aikawa Chihiro , Nakagawa Ichiro 
Published: July 2020

AbstractGroup AStreptococcus(GAS;Streptococcus pyogenes) is a major human pathogen that causes streptococcal pharyngitis, skin and soft-tissue infections, and life-threatening conditions such as streptococcal toxic-shock syndrome. During infection, GAS not only invades diverse host cells, but also injects effector proteins such as NAD-glycohydrolase (Nga) into the host cells through a streptolysin O (SLO)-dependent mechanism without invading the cells; Nga and SLO are two major virulence factors that are associated with increased bacterial virulence. Here, we have shown that the invading GAS induces fragmentation of the Golgi complex and inhibits anterograde transport in the infected host cells through the secreted toxins SLO and Nga. GAS infection-induced Golgi fragmentation required both bacterial invasion and SLO-mediated Nga translocation into the host cytosol. The cellular Golgi network is critical for the sorting of surface molecules and thus is essential for epithelial barrier integrity and the immune response of macrophages to pathogens. In epithelial cells, inhibition of anterograde trafficking by invading GAS and Nga resulted in the redistribution of E-cadherin to the cytosol and an increase in bacterial translocation across the epithelial barrier. Moreover, in macrophages, interleukin-8 secretion in response to GAS infection was found to be suppressed by intracellular GAS and Nga. Our findings reveal a previously undescribed bacterial invasion-dependent function of Nga as well as a previously unrecognized GAS-host interaction that is associated GAS pathogenesis.ImportanceTwo prominent virulence factors of GAS, SLO and Nga, have been established to be linked to enhanced pathogenicity of prevalent GAS strains. Recent advances show that SLO and Nga are important for intracellular survival of GAS in epithelial cells and macrophages. Here, we found that invading GAS disrupt the Golgi complex in host cells by SLO and Nga. We showed that GAS-induced Golgi fragmentation requires bacterial invasion into host cells, SLO pore-formation activity, and Nga NADase activity. GAS-induced Golgi fragmentation resulted in the impairment of epithelial barrier and chemokine secretion in macrophages. This immune inhibition property of SLO and Nga by intracellular GAS indicates that the invasion of GAS is associated with virulence exerted by SLO and Nga.
The emergence and development of teaching public relations in the United Arab Emirates: an in-depth look
Authors: Zamoum Khaled , Gorpe T. Serra 
Published: July 2020

PurposeThe development of teaching public relations in the United Arab Emirates (UAE) is an important topic to uncover because it is related to and to some extent parallel with the development of the UAE and its vital sectors. The purpose of the study is determine the circumstances of the emergence of teaching public relations in the UAE, to investigate public relations education offered in the UAE universities, to discuss the development of public relations education including challenges and opportunities.Design/methodology/approachThe authors conducted 12 semistructured interviews with public relations educators in the UAE universities to understand the importance, development and current status of public relations and education.FindingsThe finding indicates a lot of developments took place in the establishment of public relations programs and its professionalization within a short time span, but more empirical research is needed to address the issues that have been brought up in the study.Research limitations/implicationsThe current research looked at the undergraduate public relations programs, but the status of graduate programs in communication and public relations needs to be investigated. More research in academic field is needed to discuss how the development of the public relations education influenced the public relations practice in UAE.Originality/valueThere is not much research done specifically on the public relations education in the UAE. The study sheds light on understanding the perspective of public relations educators on public relations programs and provides insights on how public relations education can be integrated to the local context without losing the global perspective.
Perceptions of nicotine in current and former users of tobacco and tobacco harm reduction products from seven countries
Authors: Rajkumar Sarah , Adibah Nada , Paskow Michael Jonathan , Erkkila Brian Eric 
Published: July 2020

Purpose
Nicotine is widely known as a tobacco constituent and for its use as a tobacco cessation aid. The development of new devices for nicotine delivery in recent years has led to uncertainty among consumers regarding the health risks of nicotine relative to tobacco. The purpose of this study was to discover if current and former consumers of tobacco and tobacco harm reduction (THR) products could distinguish between “nicotine” and “cigarettes” and examined the preceding media dialogue to determine if conflicting messages by the media influence public perceptions.

Design/methodology/approach
A quantitative survey was administered online in Norway (NO), Japan (JP), the United Kingdom (UK) and the United States (US), while face-to-face computer-aided interviews were conducted with randomly selected samples in India (IN), Greece (GR) and South Africa (SA). Participants were between 18 and 69 years of age and either current users of tobacco and THR products or previous users who quit within the past five years. Questions assessed beliefs about harmfulness of nicotine. Nicotine and other products and substances were also independently rated for harmfulness on a scale of 1–10 and subsequently compared. In addition, the authors examined the media dialogue of top media outlets in four countries to assess the potential influence on people’s beliefs.

Findings
A total of 54,267 participants (NO: 1,700, JP: 2,227, UK: 2,250, USA: 2,309, IN: 41,633, GR: 1,801, SA: 2,359) were sampled with the percentage of women participants ranging from 14.8% (IN) to 53.8% (UK). Between 68.3% (men, IN) and 88.7% (men, USA) of current consumers believed nicotine is harmful. Current consumers who agreed with the statement that nicotine is the primary cause of tobacco-related cancer ranged from 43.7% (men, UK) to 78.0% (men, SA). In six countries nicotine was rated nearly as harmful as cigarettes and alcohol, while other substances such as sugar, salt or caffeine, were usually rated as less harmful.

Research limitations/implications
A large proportion of consumers across all surveyed countries view nicotine and cigarettes similarly. Clearer communication on the harmful properties of both by the media is needed to help consumers make informed decisions about products across the continuum of risk. Messaging to consumers, especially via the media, propagates misinformation about the relative harms of tobacco and nicotine through reporting that is often incomplete and biased toward more negative aspects.

Originality/value
This study specifically assessed public perceptions of nicotine as opposed to products containing nicotine, which is the focus of previous studies. Apart from showing that consumers often incorrectly perceive nicotine and cigarettes as similar in terms of harmfulness, the authors highlight the need for more accurate and complete reporting by the media to clarify widespread misunderstandings and mitigate public uncertainty.
Expansion plan of Central Tiffin Room: a case on accounting
Authors: Megaravalli Amith Vikram , BS Gopinath 
Published: July 2020

Learning outcomes
The case presents students with the opportunity to do the following: students can pre-work questions; understand the relevant factors to be considered in the decision to expand; and list out the industry and macro-environment factors affecting the expansion decision. Assignment questions help understand the various measures used to evaluate the financial performance of the company; understand the practical implication of incremental analysis to estimate the profit; assess the operating profit and margin of safety of the restaurant Shri Sagar with and without expansion; and critically evaluate the impact of uncertainty on projected sales using the sensitivity model.

Case overview/synopsis
Shri Sagar (Central Tiffin Room – CTR) was started by Y.V. Subramanyam and his siblings (Y.V. Srikanteshwaran, Y.V. Krishna Iyer and Y.V. Ramachandran) in the 1920s, specialised in Benne (Butter) Masala dosa, Maddur Vada and Mangalore Bajji. In Bengaluru, there are few restaurants, which have the legacy of more than 50 years such as Vidyarthi Bhavan, Mavalli Tiffin Rooms and Shri Sagar (CTR). Shri Sagar has witnessed three different ownership right from 1920 to the present. Ganesh, an MBA graduate, took the active participation in the business from 2018 and found there are potential opportunities to expand the business. Although business was doing well, Ganesh wanted to assess his company’s financial strength before proceeding. He would require a financial forecast that took into account the strength of the competition and the peculiar nature of the restaurant business in Bengaluru. Ganesh wanted to assess the expansion plan; to address the proposed plan, the case had used cost–volume–profit analysis and sensitivity analysis techniques to make the students understand how these techniques can evaluate the alternatives.

Complexity academic level
This case is best used while teaching Managerial Accounting, which is a core course in MBA program with a module on break-even-analysis or it can also be used in an executive education class with a similar purpose. The teaching plan can be used for MBA students and entrepreneurial training programmes, which involve training on important managerial decisions, which includes business expansion, estimating business profits/revenue targets, etc. It assumes some basic knowledge of cost–benefit analysis concepts where participants have already exposed some basic understanding of break-even analysis and what-if analysis.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 1: Accounting and Finance
Prediction of grain supply and demand structural balance in China based on grey models
Authors: Yang Weiming , Li Bingjun 
Published: July 2020

PurposeThe purpose of this paper is to comprehensively and accurately analyze the supply and demand structural balance of grain in the context of China's agricultural supply-side reform. By subdividing and forecasting the supply and demand, it is beneficial for targeted production in the case of clear demand and supply trends of main grain varieties.Design/methodology/approachThis paper forecasted and analyzed the demand of main grain varieties by the grey interval forecast, and based on the grey incidence analysis of more influence factors, forecasted the grain production with GM (1,N) model.FindingsThe results show that the demand and yield will keep sustainable growth in the next three years, while there is still a big gap between the supply and demand of the main grain varieties in China and the soybean's production is far behind the growing demand.Practical implicationsThis paper can make full use of the information to provide the evidence for government to formulate policies and put forward some correlative suggestions for growers.Originality/valueIn this paper, the grey model technology is applied to the structural reform of grain supply side, and different models are used to predict the structural balance of supply and demand of different kinds of grain. The study of grain supply and demand structural balance in China is vital to ensure grain security in the context of agricultural supply-side reform.
Dual solutions of the nonlinear problem of heat transfer in a straight fin with temperature-dependent heat transfer coefficient
Authors: Karamollahi Nasibeh , Barid Loghmani Ghasem , Heydari Mohammad 
Published: July 2020

Purpose
In this paper, a numerical scheme is provided to predict and approximate the multiple solutions for the problem of heat transfer through a straight rectangular fin with temperature-dependent heat transfer coefficient.

Design/methodology/approach
The proposed method is based on the two-point Taylor formula as a special case of the Hermite interpolation technique.

Findings
An explicit approximate form of the temperature distribution is computed. The convergence analysis is also discussed. Some results are reported to demonstrate the capability of the method in predicting the multiplicity of the solutions for this problem.

Originality/value
The duality of the solution of the problem can be easily predicted by using the presented method. Furthermore, the computational results confirm the acceptable accuracy of the presented numerical scheme even for estimating the unstable lower solution of the problem.
Development and validation of an instrument to measure turnover intention of Generation Y in Thailand
Authors: Na-Nan Khahan , Kanthong Suteeluck N. , Dhienhirun Auemporn 
Published: July 2020

Purpose
The turnover intention (TI) is a very challenging concept for an organisation, but there are seemingly not many instruments around to measure TI. The purpose of this paper was to develop and validate an instrument to measure the TI concept of Generation Y in Thailand.

Design/methodology/approach
Ten questions were developed as an instrument to measure TI based on previous concepts and theories and verified using exploratory factor analysis, confirmatory factor analysis and convergent validity.

Findings
Three dimensions were proposed to measure TI including aspects of intention to quit, turnover thinking and opportunities for new job with excellent reliability at 0.811, 0.837 and 0.830, respectively.

Originality/value
A measurement scale to assess TI of Generation Y salespeople has never been studied in Thailand. The measurement scale was proved to be valid and will enable human resource officers, divisions and companies to accurately analyse the level of employee TI. This instrument can help educators and researchers to better understand and comprehend factors of employee TI.
Info-analytic technologies in the work of fire and rescue units using infrared technologies
Authors: Nguyen Hai T. , Topolsky Nikolay , Tarakanov Denis , Mokshantsev Alexander 
Published: July 2020

Purpose
The salvation of human life is the goal of work for all rescue units. At the same time, a significant part of rescue operations is carried out in buildings or premises, which themselves are often in a state of destruction or are emergency ones. This paper aims to find how it is possible to carry out rescue operations in the face of the threat of constant collapse of the building.

Design/methodology/approach
To study the collapse hazard of the building, the information systems are used that display the process of rescue measures in case of a threat of deformation of the building in which there is a risk of burnback or destruction.

Findings
The findings show that the analysis of destruction parameters online allows using infrared sensors to form a picture of the allocation of places where people can be and thus saves lives while reducing the risk for the fire and rescue unit. To implement the presented format, it is proposed to use infrared sensors.

Originality/value
The use of infrared sensors allows online interaction with foci of dangerous situations and identifies the main aspects of the stratification of the preparation of the fire and rescue unit’s activities in conditions of increased danger.
Enacting governance at the local level through management control systems: the case of a multinational energy company
Authors: Granà Fabrizio , Achilli Giulia , Busco Cristiano , Izzo Maria Federica 
Published: July 2020

Purpose
This paper draws on the case of a multinational energy company to explore the role played by management control systems (MCSs) in enacting governance policies at the local (subsidiary) level.

Design/methodology/approach
This research mobilizes the literature on governmentality to interpret MCSs as technologies of government that can be drawn upon to translate governance policies into practice. In particular, the authors discuss this process by interpreting “governance” as an epistemic object, that is an object that generates knowledge because of its inherent incompleteness and abstract nature.

Findings
The paper shows how MCSs act as technical objects insofar they attract, bind and engage local subsidiary managers in the generation of knowledge about governance policies (i.e. the epistemic object) set at the global level, thereby enacting these policies locally.

Practical implications
The findings have practical implications by showing how subsidiary managers engage with MCSs to translate and implement broader governance policies in their daily activities.

Originality/value
This research contributes to the accounting literature on governmentality by showing the role of MCSs as technologies that enact governance at the local level through the process of knowledge generation that these technologies enable. Such knowledge is triggered by the engagement between different participating subjects, attracted by MCSs in the attempt to define governance in practice.
Characterizing multispecies connectivity across a transfrontier conservation landscape
Authors: Brennan Angela , Beytell Piet , Aschenborn Ortwin , Du Preez Pierre , Funston Paul J. , Hanssen Lise , Kilian J. W. , Stuart‐Hill Greg , Taylor Russell D. , Naidoo Robin 
Published: July 2020

Abstract

Connectivity conservation is aimed at sustaining animal movements and ecological processes important to ecosystem functioning and the maintenance of biodiversity. However, connectivity conservation plans are typically developed around a single species and rarely empirically evaluated for their relevance to others, thereby limiting our understanding of how connectivity requirements differ across species.

We used an omnidirectional application of circuit theory and GPS data from six species to evaluate connectivity at multiple scales for multiple species within the world's largest transfrontier conservation landscape in southern Africa. We evaluated the effects of linear barriers, natural habitat types and anthropogenic land use on movement. We identified multispecies connectivity hotspots as areas where current flow was concentrated or channelled through pinch points. To evaluate surrogate species for connectivity, we evaluated the correspondence among single‐species connectivity across the entire landscape and also examined whether a more localized corridor for African savanna elephant Loxodonta africana captured high multispecies connectivity values.

Connectivity models revealed many intact areas across the landscape with diffuse current flow, but also evidence that fences, rivers, roads and areas of anthropogenic use acted as strong barriers to movement—particularly in the case of fences, which completely blocked female elephant movement. Tests of correspondence among single‐species connectivity models revealed spotted hyaena and African wild dog as the strongest surrogate species of connectivity. Female elephants were found to be the weakest surrogate species of connectivity at the landscape scale. However, focusing within a localized elephant corridor revealed the areas of concentrated or channelled connectivity for most species in our study.

Synthesis and applications. Our results suggest that the single‐species focus permeating connectivity literature may result in conservation plans that poorly conserve the connectivity needs of co‐occurring species. Our study also highlights the importance of testing the efficacy of surrogate species for connectivity at multiple scales. We recommend evaluating multispecies connectivity to prioritize areas for conservation that safeguard the connectivity needs of multiple species of conservation concern.
The Standardisation of Tort Damages
Authors: Descheemaeker Eric 
Published: July 2020

AbstractThis article explores the nature, scope, rationale and merits of the standardisation of compensatory damages in tort law, ie the fact of giving the claimant not the value (subject to ordinary limiting principles) of his own loss, but that of the loss which an ordinary claimant placed in the same circumstances would have suffered. Standardisation happens in respect of pecuniary and non‐pecuniary losses, direct and consequential losses, and also normative losses. Its two main spurs are either that the orthodox award would not give the desired result—typically ‘too little’ damages—or that it runs into evidentiary difficulties, which the award of a typical sum overrides. While epistemic standardisation (which is not strictly standardisation) might be acceptable, the avowed granting of compensatory damages which do not aim to correspond to the claimant's own loss should be resisted, and is in any event impossible because consequential losses can never be meaningfully standardised.
Steroid hormone 20‐hydroxyecdysone promotes CTL1‐mediated cellular immunity in Helicoverpa armigera
Authors: Wang Gui‐Jie , Wang Wen‐Wen , Liu Yu , Chai Lian‐Qin , Wang Guo‐Xiu , Liu Xu‐Sheng , Wang Yu‐Feng , Wang Jia‐Lin 
Published: July 2020

AbstractMermithid nematodes, such as Ovomermis sinensis, are used as biological control agents against many insect pests, including cotton bollworm (Helicoverpa armigera). However, given the host's robust immune system, the infection rate of O. sinensis is low, thus restricting its widespread use. To understand the host defense mechanisms against mermithid nematodes, we identified and characterized a protein involved in the recognition of O. sinensis, the potential O. sinensis‐binding protein C‐type lectin 1 (HaCTL1a and/or HaCTL1b), which was eluted from the surface of O. sinensis after incubation with H. armigera plasma. HaCTL1b is homologous to the previously reported HaCTL1a protein. HaCTL1 was predominantly expressed in hemocytes and was induced by the steroid hormone 20‐hydroxyecdysone through ecdysone receptor (HaEcR) or ultraspiracle (HaUSP), or both. Binding assays confirmed the interactions of the HaCTL1 proteins with O. sinensis but not with Romanomermis wuchangensis, a parasitic nematode of mosquito. Moreover, the HaCTL1 proteins were secreted into the hemocoel and promoted hemocyte‐mediated encapsulation and phagocytosis. A knockdown of HaEcR and/or HaUSP resulted in compromised encapsulation and phagocytosis. Thus, HaCTL1 appears to modulate cellular immunity in the defense against parasitic nematodes, and the 20‐hydroxyecdysone–HaEcR–HaUSP complex is involved in regulating the process.