bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel technique of performing multivessel PCI through an Impella sheath
Authors: Kumar Kris , Reddy Sridhar , Acharya Deepak , Lotun Kapildeo 
Published: November 2019

AbstractA 69‐year‐old woman with diabetes was found to have multi‐vessel coronary artery disease and underwent 5‐vessel coronary artery bypass grafting. Patient had persistent cardiogenic shock postoperatively despite intra‐aortic balloon pump and escalating pressor requirements. Electrocardiogram showed new ischemic changes and the patient was urgently taken to the catheterization lab for coronary angiography and placement of an Impella CP for higher degree of hemodynamic support via the left femoral artery. Due to limitations in vascular access the Impella CP sheath was utilized for vascular access for diagnostic angiography and coronary intervention concurrently with ongoing Impella CP support. The first obtuse marginal had severe proximal disease and was treated with percutaneous coronary intervention (PCI) with a drug eluting stent. To our knowledge, this case is the first in which successful diagnostic angiography as well as multi‐vessel PCI was performed via an Impella sheath while concurrently using the percutaneous mechanical circulatory support system of the Impella CP. Multiple guide catheters and a pigtail catheter were successfully passed via the Impella CP sheath to perform PCI. This novel method of vascular access could be an important tool to use in high‐risk patients with limitations in access sites and decrease potential bleeding complications by limiting the number of arterial punctures.
Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study
Authors: Briguori Carlo , Tamburino Corrado , Jessurun Gillian A. J. , Meyer‐Geßner Markus , Reczuch Krzysztof , Cortese Bernardo , Maillard Luc , Anthonio Rutger L. , La Manna Alessio , Morice Marie‐Claude , Bouchez David , Balland Anaïs , Huynh Vi‐Phong , Baumbach Andreas 
Published: November 2019

AbstractObjectivesTo assess long‐term safety and efficacy of the Xposition S self‐apposing stent in the treatment of unprotected left main coronary artery (ULMCA) disease.BackgroundPercutaneous intervention with stents has emerged as a valid alternative to surgical revascularization to treat ULMCA disease. Conventional balloon‐expandable stents face technical challenges, particularly in large left main diameter requiring extensive optimization and side branch access in distal bifurcation. Xposition S allows for optimal apposition, bridging diameter differences, and allows expansion to vessel diameters up to 6.0 mm.MethodsBetween June 2016 and July 2017, 205 patients were enrolled in this international, prospective, multicenter registry. Patients with SYNTAX score ≥ 33 or recent STEMI were excluded. IVUS during procedure was performed in a prespecified subgroup of 50 patients. The primary clinical endpoint was 12 months Target lesion failure (TLF) and the primary efficacy endpoint was angiographic success.ResultsDistal left main bifurcation was involved in 92.7%, treated with provisional approach in most cases (79.4%). TLF rate at 12 months was 8.3%, which was defined as a composite of cardiac death (2.0%), target‐vessel MI (2.9%), and TLR (5.4%). Most revascularizations occurred at SB ostium. IVUS analysis demonstrated optimal stent apposition with only one reported malapposition and promising poststenting minimal stent area measures.ConclusionsThe TRUNC study confirms that Xposition S self‐apposing stent is a valid and feasible option for the treatment of ULMCA disease. Such results were reached without the systematic need of stent optimisation techniques, focusing mainly on lesion treatment.
Chronic total occlusion recanalization for myocardial infarction
Authors: Xenogiannis Iosif , Nikolakopoulos Ilias , Vemmou Evangelia , Brilakis Emmanouil S. 
Published: November 2019

AbstractAn 84‐year‐old patient with prior coronary artery bypass surgery presented with non‐ST segment elevation acute myocardial infarction. The culprit lesion was at the distal anastomosis of a saphenous vein graft (SVG) to the right posterior descending artery. The proximal right coronary artery was chronically occluded. Because of significant disease both proximal and distal to the SVG anastomosis, percutaneous intervention of the SVG carried high risk for acute vessel closure. The native right coronary artery chronic total occlusion was successfully recanalized, enabling complete revascularization of the right coronary artery. The SVG was then occluded using an Amplatzer vascular plug.
Two cases of pericardial tamponade due to nitinol wire fracture of a gore septal occluder
Authors: Kumar Preetham , Orford James L. , Tobis Jonathan M. 
Published: November 2019

AbstractPercutaneous patent foramen ovale (PFO) closure is recommended for secondary prevention of paradoxical embolism through a PFO. In the United States, two Food and Drug Administration‐approved PFO closure devices are currently available, and the choice depends on operator preference and PFO anatomy. Although these devices are easy to implant, there are several potential complications. As opposed to the Amplatzer PFO Occluder, there has been no published case of atrial erosion with Gore closure devices. This report describes two cases of pericardial tamponade due to perforation of the atrial wall induced by a wire frame fracture of the Gore Helex and Cardioform devices.
Interval state and sensor fault estimation based on unknown input observer and interval hull computation
Authors: Zhou Meng , Cao Zhengcai , Wang Jing , Wang Chang 
Published: November 2019

AbstractThis paper investigates the problem of interval estimation of state and sensor fault simultaneously based on the unknown input decoupling technique and interval hull computation approach. To facilitate sensor fault estimation conveniently, it is first regarded as an auxiliary state, and the faulty system is transformed into an augmented descriptor system. Next, an unknown input observer is designed based on the P‐radius method for this augmented descriptor system to decouple some of the unknown system disturbance. Then, the bounds of the augmented state set effected by the undecoupled system uncertainties are calculated via an interval hull approximation technique. Finally, the effectiveness and practicality of this work are illustrated by a numerical example and a quadruple‐tank process system. This work demonstrates that by decoupling some unknown disturbances from the estimation error system, the zonotope's size, corresponding to state and sensor fault estimation, can be further reduced.
Structure−Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents
Authors: Bernal Freddy A. , Kaiser Marcel , Wünsch Bernhard , Schmidt Thomas J. 
Published: November 2019

AbstractProtozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub‐tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure‐activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure‐dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro‐aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol‐type compounds against T. brucei could not be extrapolated to an in vivo mouse model.
Performance analysis of polling‐based MAC protocol with retrial for Internet of Things
Authors: Guan Zheng , Xiong Lei , He Min , Qian Wen‐Hua , Zhou Zhaoxu 
Published: November 2019

SummaryWe consider and analyze a single‐server multiqueue polling model with inner arrivals. Customers arriving at the queue before polling instant could receive service in the current polling round; furthermore, each one could be retried (turns into an inner arrival) a given number of times with a specified probability. Such polling model can be used to study the performance of certain scheduling data transmission in the Internet of Things (IoT) and the relationship between data retransmission and delay. We obtain the closed‐form expression for the generating function of the amount of customers, which are presented at polling instants. Then, it is used to derive the precise closed‐form formula of mean queue length and mean waiting time in symmetric system.
An efficient privacy‐enhanced attribute‐based access control mechanism
Authors: Xu Yang , Zeng Quanrun , Wang Guojun , Zhang Cheng , Ren Ju , Zhang Yaoxue 
Published: November 2019

SummaryOwing to the rapid progress of network researching, attribute‐based access control (ABAC) has attracted more and more attention due to its appreciable expressiveness, flexibility, and scalability. Unfortunately, collecting user attributes is necessary to complete the standard ABAC decision process, which increases the risk of privacy disclosure. This problem increases public doubts about ABAC and hinders its popularization. In this paper, a privacy‐protected and efficient attribute‐based access control (EPABAC) scheme is proposed to prevent the privacy leakage of access subject in the decision‐making process of ABAC by introducing a novel hash‐based binary search tree. The analyses and experimental evaluations show that the EPABAC achieves user privacy protection in the decision‐making process with acceptable additional computing overhead.
Liquid Marble Photosensor
Authors: Adamatzky Andrew , Tsompanas Michail‐Antisthenis , Draper Thomas C. , Fullarton Claire , Mayne Richard 
Published: November 2019

AbstractA liquid marble is a liquid droplet coated by a hydrophobic powder. The liquid marble does not wet adjacent surfaces and therefore can be manipulated as a dry soft body. A Belousov‐Zhabotinsky (BZ) reaction is an oscillatory chemical reaction exhibiting waves of oxidation. We demonstrate how to make a photo‐sensor from BZ medium liquid marbles. We insert electrodes into a liquid marble, prepared from BZ solution and coated with polyethylene powder. The electrodes record a potential difference which oscillates due to oxidation wave‐fronts crossing the electrodes. When the BZ marble is illuminated by a light source, the oxidation wave‐fronts are hindered and, thus, the electrical potential recorded ceases to oscillate. We characterise several types of responses of BZ marble photosensors to various stimuli, and provide explanations of the recorded activity. BZ liquid marble photosensors may find applications in the fields of liquid electronics, soft robotics and unconventional computing.
A phase‐correlated duo‐binary waveform generation technique for millimeter‐wave radar pulses
Authors: Heunisch Sebastian , Ohlsson Fhager Lars , Wernersson Lars‐Erik 
Published: November 2019

SummaryWe propose a technique for generating millimeter‐wave radar waveforms using edge‐triggered pulse generator circuits. By synchronizing the chip rate to the oscillation frequency of a binary control signal, a phase shift is introduced in the generated pulses. This way, the millimeter‐wave signal can be phase‐modulated without the need of additional circuit elements. We show that high‐resolution radar waveforms with low range side lobes can be generated with this technique. Using brute‐force optimization, we evaluate all possible sequences up to a sequence length of 25 chips and identify optimal waveforms for each length. Optimal sequences with the energy centered at zero delay and side lobes not exceeding unity are presented. The optimized waveforms are measured and verified using an in‐house resonant tunneling diode (RTD) metal‐oxide‐semiconductor field‐effect transistor (MOSFET) pulse generator. The matched filter response of the optimal waveforms is reproduced closely in the measurements. The results enable increased sensitivity in radar systems using coherent millimeter‐wave pulse generators for low power applications, as for instance, radar gesture recognition in handheld devices. Using pulsed millimeter‐wave radar systems with low duty cycles, continuously running oscillators can be avoided and systems with ultra‐low power consumption are possible.
Common flow cytometry pitfalls in diagnostic hematopathology
Authors: Cherian Sindhu , Hedley Ben D. , Keeney Michael 
Published: November 2019

AbstractFlow cytometry (FC) has proven to be an extremely versatile and useful tool in the diagnosis and monitoring of hematological diseases in addition to numerous other applications. Major advances in electronics, software, and reagents over the past years have simplified some aspects of FC, while at the same time the ability to combine 8–10 antibodies in a single tube can create both technical and interpretation issues that are more difficult to detect when using only 3–4 color combinations. Use of multiparameter panels can facilitate identification of abnormal populations; however, characteristics of the neoplastic population may create potential diagnostic pitfalls. An understanding of normal immunophenotypic patterns in states of rest, recovery, and activation is a critical first step in order to appropriately identify the abnormal populations that characterize hematopoietic neoplasms. Additionally, incorporation of newer therapeutic strategies, in particular targeted therapies, can confound standard methods for flow cytometric data analysis and knowledge of the impact of therapy on flow cytometric data is critical for accurate data interpretation. This manuscript will review preanalytical, instrument, and interpretation issues that may lead to incorrect interpretation of results.
Fine needle aspiration cytology of epididymal nodules and its corroboration with ultrasonographic‐histological findings
Authors: Mondal Krishnendu , Mandal Rupali , Saha Amitava , Shahabuddin MD , Sarkar Ranjan 
Published: November 2019

AbstractBackgroundFine needle aspiration cytology (FNAC) assisted with scrotal ultrasonography is the best preoperative diagnostic modality for palpable epididymal nodules. It also aids in their successive remedial approach as well as serves semi‐therapeutically in cystic lesions. The objectives of this study are to recognize the spectrum of pathological conditions giving rise to epididymal nodules, then to compare them with corresponding ultrasound images, and to evaluate the histological features wherever practicable.MethodsTotal 62 patients underwent FNAC as well as sonographic evaluation for their epididymal nodules. Histopathology was performed in only 20 cases.ResultsEpididymitis either caused by tuberculosis (30.6%), or in its acute (11.3%) and chronic (8.1%) forms remained the commonest cytological diagnosis. Neoplastic lesions included mostly adenomatoid tumors (8.1%), and another case of seminomatous spread from ipsilateral testicular primary. Nineteen of the excised masses corroborated with their respective cytodiagnoses. The discrepant lesion was actually a papillary cystadenoma, which was cytologically misinterpreted as adenomatoid tumor.ConclusionsFNAC becomes the first‐hand investigative measure for epididymal nodules, by virtue of its early, easy and highly accurate diagnostic implications. It segregates the patients into proper therapeutic protocol and thereby estranges those who really need operative management. When deployed together with ultrasound, the diagnostic accuracy of FNAC improves further.
Hematological changes following an Ironman triathlon: An antidoping perspective
Authors: Miller Geoffrey D. , Beharry Adam , Teramoto Masaru , Lai Auriella , Willick Stuart E. , Eichner Daniel 
Published: November 2019

AbstractUnderstanding and characterizing confounding factors to the Athlete Biological Passport (ABP) is crucial for the reliable interpretation of biological profiles in the antidoping field. The physiological effects on hematological parameters and plasma volume (PV) following competition in a long‐distance triathlon, as seen in the Ironman discipline, have yet to be fully described and are the focus of this study. Complete blood count blood tests were conducted on 19 Ironman triathletes before and after an Ironman triathlon to characterize changes in hematological parameters and the effect on ABP interpretation, as it was hypothesized that changes in the plasma volume may result in the presentation of atypical ABP profiles. Baseline blood samples were collected from the athletes prior to the event, and one sample was collected per day for up to 1 week following the race. Differences were observed between the male and female athletes across multiple parameters. Most importantly to the ABP, decreases in hemoglobin concentration (HGB) and hematocrit (HCT) were identified post‐race, with the largest decreases identified on day +2. The average HGB returned to pre‐race baseline levels on day +5. Beginning 5–6 days after the race, increases in the reticulocyte percentage (Ret%) were identified. Atypical Passport Findings were identified in 32% (6/19) of the ABPs, flagged mainly due to atypical hemoglobin concentration and one instance in which the OFF‐score exceeded the adaptive model limits. These results offer a characterized timeline of hematological changes and expected shifting of plasma volume following an Ironman triathlon providing important data for the reliable interpretation of ABP profiles in this field.
Sex matters: Otolith shape and genomic variation in deacon rockfish (Sebastes diaconus)
Authors: Vaux Felix , Rasmuson Leif K. , Kautzi Lisa A. , Rankin Polly S. , Blume Matthew T. O. , Lawrence Kelly A. , Bohn Sandra , O'Malley Kathleen G. 
Published: November 2019

AbstractLittle is known about intraspecific variation within the deacon rockfish (Sebastes diaconus), a recently described species found in the northeast Pacific Ocean. We investigated population structure among fish sampled from two nearshore reefs (Siletz Reef and Seal Rock) and one offshore site (Stonewall Bank) within a <50‐km2 area off the Oregon coast. Fish from the three sample sites exhibited small but statistically significant differences based on genetic variation at >15,000 neutral loci, whether analyzed independently or classified into nearshore and offshore groups. Male and females were readily distinguished using genetic data and 92 outlier loci were associated with sex, potentially indicating differential selection between males and females. Morphometric results indicated that there was significant secondary sexual dimorphism in otolith shape, but further sampling is required to disentangle potential confounding influence of age. This study is the first step toward understanding intraspecific variation within the deacon rockfish and the potential management implications. Since differentiation among the three sample sites was small, we consider the results to be suggestive of a single stock. However, future studies should evaluate how the stock is affected by differences in sex, age, and gene flow between the nearshore and offshore environments.
Combined effects of growth hormone and testosterone replacement treatment in heart failure
Authors: Salzano Andrea , Marra Alberto M. , Arcopinto Michele , D'Assante Roberta , Triggiani Vincenzo , Coscioni Enrico , Pasquali Daniela , Rengo Giuseppe , Suzuki Toru , Bossone Eduardo , Cittadini Antonio 
Published: November 2019

AbstractAimsAlthough preliminary studies have demonstrated safety and effectiveness of single replacement therapy for growth hormone deficiency or testosterone deficiency in heart failure (HF), no data are available regarding the combined treatment with both GH and T in this setting. Thus, the aim of the present hypothesis generating pilot study was to evaluate the effectiveness and safety of multiple hormonal replacement therapies in chronic HF.Methods and resultsFive stable HF with reduced ejection fraction patients, with a concomitant diagnosis of growth hormone deficiency and testosterone deficiency, on top of guideline‐based HF treatment underwent 1 year of GH replacement therapy by subcutaneous injections of somatotropin at a dose of 0.012 mg/kg every second day. After 12 months, a T replacement treatment was added at a dosage of 1000 mg every 3 months. Each patient underwent a complete M‐mode, two‐dimensional, and Doppler echocardiographic examination, and an incremental symptom‐limited cardiopulmonary exercise test on a bicycle ergometer at baseline (BL), after 1 year of GH treatment (V1), and after 1 year of combined GH + T treatments (V2). One‐year of GH treatment resulted in a significant improvement in left ventricular ejection fraction (+5.4%, P < 0.01), New York Heart Association functional class (P < 0.05), and peak oxygen consumption (VO2 peak) (+19.3%, P < 0.01), and in a significant reduction in NT‐proBNP levels (−35.1%, P < 0.01). Notably, one additional year of combined GH and T replacement therapy induced a further increase in VO2 peak (+27.7%, final delta change + 52.44%, P < 0.01), as well as a significant improvement in muscular strength, as assessed by handgrip dynamometry (+17.5%, final delta change + 25.8%, P < 0.01). These beneficial effects were paralleled with an improvement of the overall clinical status (as assessed by New York Heart Association class). Of note, neither adverse effects nor cardiovascular events were reported during the follow‐up period.ConclusionsOur preliminary data suggest for the first time that combined replacement therapy with GH and T could be considered safe and therapeutic in HF patients with multiple hormone deficiencies, supporting the hypothesis that multiple hormone deficiencies syndrome can be considered as a novel and promising therapeutic target in HF. Further studies with a more robust design and larger population are needed.
Myocardial adipose deposition and the development of heart failure with preserved ejection fraction
Authors: Wu Cho‐Kai , Lee Jen‐Kuang , Hsu Jung‐Chi , Su Mao‐Yuan M. , Wu Yi‐Fan , Lin Ting‐Tse , Lan Chen‐Wei , Hwang Juey‐Jen , Lin Lian‐Yu 
Published: November 2019

AbstractAimsIt has been proposed that an increase of myocardial adiposity is related to left ventricular (LV) diastolic dysfunction. The specific roles of myocardial steatosis including epicardial fat and intramyocardial fat for diastolic function are unknown in those patients suffering heart failure (HF) with reduced (HFrEF) or preserved ejection fraction (HFpEF). This study aims to determine the complex relationship between myocardial adiposity in patients with HFrEF or HFpEF.Methods and resultsUsing cardiac magnetic resonance imaging (CMRI), myocardial steatosis was measured in 305 subjects (34 patients with HFrEF, 163 with HFpEF, and 108 non‐HF controls). We also evaluated cardiac structure and diastolic and systolic function by echocardiography and CMRI. Patients with HFpEF had significantly more intramyocardial fat than HFrEF patients or non‐HF controls [intramyocardial fat content (%), 1.56 (1.26, 1.89) vs. 0.75 (0.50, 0.87) and 1.0 (0.79, 1.15), P < 0.05]. Intramyocardial fat amount (%) was higher in HFpEF women than in men [1.91% (1.17%, 2.32%) vs. 1.22 (0.87%, 2.02%), P = 0.01]. When estimated by CMRI (left ventricular peak filling rate), echocardiographic E/e′ level, or left atrial volume index, intramyocardial fat correlated with LV diastolic dysfunction parameters in HFpEF patients, and this was independent of age, co‐morbidities, body mass index, gender, and myocardial fibrosis (standardized coefficient: β = −0.34, P = 0.03; β = 0.29, P = 0.025; and β = 0.25, P = 0.02, respectively).ConclusionsPatients with HFpEF had significantly more intramyocardial fat than HFrEF patients or non‐HF controls. Independent of risk factors or gender, intramyocardial fat correlated with LV diastolic dysfunction parameters in HFpEF patients.