bluuebunny/crossref_metadata_2025_split huggingface dataset:
An e-registry for household contacts exposed to multidrug resistant TB in Mongolia
Authors: Naker Kush , Gaskell Katherine M. , Dorjravdan Munhjargal , Dambaa Naranzul , Roberts Chrissy H. , Moore David A. J. 
Published: August 2020

Abstract
Background
The WHO recommends that individuals exposed to persons with multidrug resistant tuberculosis (MDRTB) should be screened for active TB and followed up for 2 years to detect and treat secondary cases early. Resource prioritisation means this is rarely undertaken and where it is performed it’s usually using a paper-based record, without collation of data. Electronic data collection into a web-based registry offers the opportunity for simplified and systematic TB contact surveillance with automatic synthesis of data at local, regional and national level. This pilot study was designed to explore the feasibility of usage of a novel e-registry tool and explore obstacles and facilitating factors to implementation.

Methods
In parallel with their paper records, seven dispensaries in Ulaanbaatar, Mongolia collected standardized data electronically using Open Data Kit (ODK). Patients with MDRTB and their contacts were recruited during a single clinic visit. Staff and patients were interviewed to gain insights into acceptability and to identify areas for improvement.

Results
Seventy household contacts of 32 MDR-TB index patients were recruited. 7/70 contacts (10%) traced had active TB at the time they were recruited to the e-registry.
Paper registry satisfaction was low; 88% of staff preferred the e-registry as it was perceived as faster and more secure. Patients and their contacts were generally supportive of the e-registry; however, a significant minority 10/42 (24%) of index cases who were invited, declined to participate in the e-registry, with data security cited as their top concern.

Conclusion
E-registries are a promising tool for MDRTB contact tracing, but their acceptability amongst patients should not be taken for granted.
Proteomic study of hypothalamus in pigs exposed to heat stress
Authors: Yu Tian-yue , Yong Yan-hong , Li Jun-yu , Fang Biao , Hu Can-ying , Wu Lian-yun , Liu Xiaoxi , Yu Zhichao , Ma Xingbin , Patil Yadnyavalkya , Gooneratne Ravi , Ju Xiang-hong 
Published: August 2020

AbstractBackgroundWith evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Studying the changes in the brain proteome induced by heat stress may aid in understanding how heat stress affects brain function. The hypothalamus is a critical region in the brain that controls the pituitary gland, which is responsible for the secretion of several important hormones. In this study, we examined the hypothalamic protein profile of 10 pigs (15 ± 1 kg body weight), with five subjected to heat stress (35 ± 1 °C; relative humidity = 90%) and five acting as controls (28 ± 3 °C; RH = 90%).ResultThe isobaric tags for relative and absolute quantification (iTRAQ) analysis of the hypothalamus identified 1710 peptides corresponding to 360 proteins, including 295 differentially expressed proteins (DEPs), 148 of which were up-regulated and 147 down-regulated, in heat-stressed animals. The Ingenuity Pathway Analysis (IPA) software predicted 30 canonical pathways, four functional groups, and four regulatory networks of interest. The DEPs were mainly concentrated in the cytoskeleton of the pig hypothalamus during heat stress.ConclusionsIn this study, heat stress significantly increased the body temperature and reduced daily gain of body weight in pigs. Furthermore, we identified 295 differentially expressed proteins, 147 of which were down-regulated and 148 up-regulated in hypothalamus of heat stressed pigs. The IPA showed that the DEPs identified in the study are involved in cell death and survival, cellular assembly and organization, and cellular function and maintenance, in relation to neurological disease, metabolic disease, immunological disease, inflammatory disease, and inflammatory response. We hypothesize that a malfunction of the hypothalamus may destroy the host physical and immune function, resulting in decreased growth performance and immunosuppression in heat stressed pigs.
Alpha- and gammaherpesviruses in stranded striped dolphins (Stenella coeruleoalba) from Spain: first molecular detection of gammaherpesvirus infection in central nervous system of odontocetes
Authors: Vargas-Castro Ignacio , Crespo-Picazo José Luis , Rivera-Arroyo Belén , Sánchez Rocío , Marco-Cabedo Vicente , Jiménez-Martínez María Ángeles , Fayos Manena , Serdio Ángel , García-Párraga Daniel , Sánchez-Vizcaíno José Manuel 
Published: August 2020

AbstractBackgroundHerpesvirus infections in cetaceans have always been attributed to theAlphaherpesvirinaeandGammaherpesvirinaesubfamilies. To date, gammaherpesviruses have not been reported in the central nervous system of odontocetes.Case presentationA mass stranding of 14 striped dolphins (Stenella coeruleoalba) occurred in Cantabria (Spain) on 18th May 2019. Tissue samples were collected and tested for herpesvirus using nested polymerase chain reaction (PCR), and for cetacean morbillivirus using reverse transcription-PCR. Cetacean morbillivirus was not detected in any of the animals, while gammaherpesvirus was detected in nine male and one female dolphins. Three of these males were coinfected by alphaherpesviruses. Alphaherpesvirus sequences were detected in the cerebrum, spinal cord and tracheobronchial lymph node, while gammaherpesvirus sequences were detected in the cerebrum, cerebellum, spinal cord, pharyngeal tonsils, mesenteric lymph node, tracheobronchial lymph node, lung, skin and penile mucosa. Macroscopic and histopathological post-mortem examinations did not unveil the potential cause of the mass stranding event or any evidence of severe infectious disease in the dolphins. The only observed lesions that may be associated with herpesvirus were three cases of balanitis and one penile papilloma.ConclusionsTo the authors’ knowledge, this is the first report of gammaherpesvirus infection in the central nervous system of odontocete cetaceans. This raises new questions for future studies about how gammaherpesviruses reach the central nervous system and how infection manifests clinically.
Performance of IRS on malaria prevalence and incidence using pirimiphos-methyl in the context of pyrethroid resistance in Koulikoro region, Mali
Authors: Kané Fousseyni , Keïta Moussa , Traoré Boïssé , Diawara Sory Ibrahim , Bane Sidy , Diarra Souleymane , Sogoba Nafomon , Doumbia Seydou 
Published: August 2020

Abstract
Background
Koulikoro Health District is one of three districts of Mali where the indoor residual spray (IRS) has been implemented from 2008 to 2016. With widespread of resistance to pyrethroid, IRS was shifted from pyrethroid to pirimiphos-methyl from 2014 to 2016. The objective of this study was to assess the added value of IRS to LLINs on the prevalence of parasitaemia and malaria incidence among children under 10 years old.

Methods
A comparative study was carried out to assess the effects of pirimiphos-methyl based IRS on malaria prevalence and incidence among children from 6 months to 10 years old in selected pyrethroid resistance villages of two health districts in Mali: one where IRS was implemented in combination with LLINs (intervention area) and one with LLINs-only (control area). Two cross-sectional surveys were carried out at the beginning (June) and end of the rainy season (October) to assess seasonal changes in malaria parasitaemia by microscopy. A passive detection case (PCD) was set-up in each study village for 9 months to estimate the incidence of malaria using RDT.

Results
There was an increase of 220% in malaria prevalence from June to October in the control area (14% to 42%) versus only 53% in the IRS area (9.2% to 13.2%). Thus, the proportional rise in malaria prevalence from the dry to the rainy season in 2016 was 4-times greater in the control area compared to the IRS area. The overall malaria incidence rate was 2.7 per 100 person-months in the IRS area compared with 6.8 per 100 person-month in the control areas. The Log-rank test of Kaplan–Meier survival analysis showed that children living in IRS area remain much longer free from malaria (Hazard ratio (HR) = 0.45, CI 95% 0.37–0.54) than children of the control area (P < 0.0001).

Conclusions
IRS using pirimiphos-methyl has been successful in reducing substantially both the prevalence and the incidence of malaria in children under 10 years old in the area of pyrethroid resistance of Koulikoro, Mali. Pirimiphos-methyl is a better alternative than pyrethroids for IRS in areas with widespread of pyrethroid resistance.
COVID-19 response strategies: considering inequalities between and within countries
Authors: Lau Lincoln Leehang , Hung Natalee , Wilson Kendall 
Published: August 2020

AbstractGlobally, the COVID-19 pandemic has been uncharted territory, and countries and governments have faced the challenge of implementing response strategies to manage local transmission. High-income settings have the resources to devote significant resources to testing, isolation, and contact tracing. Lower-income settings are pressured to emulate such initiatives, but often lack the resources and infrastructure to do so. We highlight the impact of these between-country inequalities, the within-country inequalities, and the potential magnification of unintended consequences due to COVID-19 control measures.
Validation of the Substance Use Risk Profile Scale in Lithuanian population
Authors: Kaminskaite Migle , Pranckeviciene Aiste , Bunevicius Adomas , Janaviciute Jovita , Jokubonis Darius , Plioplyte Aistė , Lelyte Inesa , Sinkariova Liuda , Jokubka Ramunas 
Published: August 2020

Abstract
Background
Personality traits are related with risk of hazardous alcohol use and alcohol dependence. The Substance Use Risk Profile Scale (SURPS) measures personality traits associated with addictive substance abuse. We examined psychometric properties of the SURPS in Lithuanian population.

Materials and methods
Two hundred forty-seven participants (mean age 37.22 ± 0.78 years), were recruited from the local community and from an inpatient addiction treatment centre. Internal consistency, stability, factor structure, content validity, and external validity of the SURPS were examined. Hazardous alcohol use was evaluated by Alcohol Use Disorder Identification Test (AUDIT). Alcohol dependence diagnosis was established by International Classification of Diseases - 10 (ICD - 10). We also performed gender analyses for associations of personality traits with alcohol dependence and hazardous use of alcohol.

Results
The SURPS scale demonstrated appropriate internal validity, good temporal stability, and adequate criterion validity and construct validity. The SURPS scores of hopelessness, anxiety sensitivity and impulsivity were higher in the alcohol dependence group than in the control group for both males and females. Impulsivity and sensation seeking were associated with hazardous alcohol use and these associations were more prevalent in females.

Conclusions
Lithuanian translation of the SURPS scale was appropriate. The SURPS demonstrated good sensitivity for discriminating on alcohol dependence and was more sensitive for discriminating on hazardous alcohol use for females.
Development and psychometric evaluation of the healthy lifestyle questionnaire for elderly (heal)
Authors: Bandari Razieh , Mohammadi Shahboulaghi Farahnaz , Montazeri Ali 
Published: August 2020

AbstractBackgroundThe present study was conducted to design and evaluate the psychometric properties of a questionnaire for assessing the healthy lifestyle among older adults in Iran.MethodsFirst, items were generated based on a qualitative study, the literature review, and with help received from experts in gerontology and questionnaire design. Then, content validity was carried out. Accordingly, a cross sectional study was conducted to perform factor analysis and known groups comparison in order to examine the construct validity. Internal consistency was measured by the Cronbach’s alpha coefficient and the stability of the questionnaire was evaluated by estimating interclass correlation coefficient (ICC).ResultsIn total 68 items was generated. Following development process 22 items were removed and a provisional version of the questionnaire with 46 items was subjected to psychometric evaluation. At this stage a sample of 390 elderly people attending the community centers in Tehran, Iran were entered into the study and completed the questionnaire. Most elderly were female (52.8%) and the mean age of participants was 67.97 (SD ± 7.77) years. After performing factor analysis, overall 10 items were removed due to low loading and the questionnaire was reduced to 35 items tapping into eight factors, which explained a total of 57.1% of the variance. In addition, the results obtained from known groups comparison indicated that the questionnaire well differentiated among participants who were differed in self-reported health condition. The Cronbach’s alpha coefficient showed excellent internal consistency (alpha = 0.89). The intraclass correlation coefficient also indicated a good stability for the questionnaire (ICC = 0.94).ConclusionThe healthy lifestyle questionnaire for elderly (Heal) can be used as a simple and an easy-to-use valid and reliable measure in determining healthy life style and the frequency of health-oriented activities among older adults.
Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial
Authors: Goss Amy M , Gower Barbara , Soleymani Taraneh , Stewart Mariah , Pendergrass May , Lockhart Mark , Krantz Olivia , Dowla Shima , Bush Nikki , Garr Barry Valene , Fontaine Kevin R. 
Published: August 2020

Abstract
Background
Insulin resistance and accumulation of visceral adipose tissue (VAT) and intermuscular adipose tissue (IMAT) place aging adults with obesity at high risk of cardio-metabolic disease. A very low carbohydrate diet (VLCD) may be a means of promoting fat loss from the visceral cavity and skeletal muscle, without compromising lean mass, and improve insulin sensitivity in aging adults with obesity.

Objective
To determine if a VLCD promotes a greater loss of fat (total, visceral and intermuscular), preserves lean mass, and improves insulin sensitivity compared to a standard CHO-based/low-fat diet (LFD) in older adults with obesity.

Design
Thirty-four men and women aged 60–75 years with obesity (body mass index [BMI] 30-40 kg/m2) were randomized to a diet prescription of either a VLCD (< 10:25:> 65% energy from CHO:protein:fat) or LFD diet (55:25:20) for 8 weeks. Body composition by dual-energy X-ray absorptiometry (DXA), fat distribution by magnetic resonance imaging (MRI), insulin sensitivity by euglycemic hyperinsulinemic clamp, and lipids by a fasting blood draw were assessed at baseline and after the intervention.

Results
Participants lost an average of 9.7 and 2.0% in total fat following the VLCD and LFD, respectively (p < 0.01). The VLCD group experienced ~ 3-fold greater loss in VAT compared to the LFD group (− 22.8% vs − 1.0%, p < 0.001) and a greater decrease in thigh-IMAT (− 24.4% vs − 1.0%, p < 0.01). The VLCD group also had significantly greater thigh skeletal muscle (SM) at 8 weeks following adjustment for change in total fat mass. Finally, the VLCD had greater increases in insulin sensitivity and HDL-C and decreases in fasting insulin and triglycerides compared to the LFD group.

Conclusions
Weight loss resulting from consumption of a diet lower in CHO and higher in fat may be beneficial for older adults with obesity by depleting adipose tissue depots most strongly implicated in poor metabolic and functional outcomes and by improving insulin sensitivity and the lipid profile.

Trial registration
NCT02760641. Registered 03 May 2016 - Retrospectively registered.
Low-dose cone-beam CT (LD-CBCT) reconstruction for image-guided radiation therapy (IGRT) by three-dimensional dual-dictionary learning
Authors: Song Ying , Zhang Weikang , Zhang Hong , Wang Qiang , Xiao Qing , Li Zhibing , Wei Xing , Lai Jialu , Wang Xuetao , Li Wan , Zhong Quan , Gong Pan , Zhong Renming , Zhao Jun 
Published: August 2020

AbstractBackgroundTo develop a low-dose cone beam CT (LD-CBCT) reconstruction method named simultaneous algebraic reconstruction technique and dual-dictionary learning (SART-DDL) joint algorithm for image guided radiation therapy (IGRT) and evaluate its imaging quality and clinical application ability.MethodsIn this retrospective study, 62 CBCT image sets from February 2018 to July 2018 at west china hospital were randomly collected from 42 head and neck patients (mean [standard deviation] age, 49.7 [11.4] years, 12 females and 30 males). All image sets were retrospectively reconstructed by SART-DDL (resultant D-CBCT image sets) with 18% less clinical raw projections. Reconstruction quality was evaluated by quantitative parameters compared with SART and Total Variation minimization (SART-TV) joint reconstruction algorithm with pairedttest. Five-grade subjective grading evaluations were done by two oncologists in a blind manner compared with clinically used Feldkamp-Davis-Kress algorithm CBCT images (resultant F-CBCT image sets) and the grading results were compared by paired Wilcoxon rank test. Registration results between D-CBCT and F-CBCT were compared. D-CBCT image geometry fidelity was tested.ResultsThe mean peak signal to noise ratio of D-CBCT was 1.7 dB higher than SART-TV reconstructions (P < .001, SART-DDL vs SART-TV, 36.36 ± 0.55 dB vs 34.68 ± 0.28 dB). All D-CBCT images were recognized as clinically acceptable without significant difference with F-CBCT in subjective grading (P > .05). In clinical registration, the maximum translational and rotational difference was 1.8 mm and 1.7 degree respectively. The horizontal, vertical and sagittal geometry fidelity of D-CBCT were acceptable.ConclusionsThe image quality, geometry fidelity and clinical application ability of D-CBCT are comparable to that of the F-CBCT for head-and-neck patients with 18% less projections by SART-DDL.
A finite element analysis on comparing the stability of different posterior fixation methods for thoracic total en bloc spondylectomy
Authors: Liang Yun , Cao Yuanwu , Gong Zhiguo , Jiang Chang , Jin Lixia , Li Zheng , Chen Zixian , Jiang Chun , Jiang Xiaoxing 
Published: August 2020

Abstract
Objective
To compare the spinal stability with different fixation methods after thoracic TES using finite element analysis

Methods
The spinal finite element model was established from a healthy volunteer, and the validity was verified. The models of T8 thoracic total en bloc spondylectomy (TES) with and without artificial vertebral body were established combination with different fixation methods: the first was long segment fixation with fixed segments T5–7, T9–11; the second was short segment fixation with fixed segments T6–7, T9–10; the third was modified short segment with a pair of vertebral body screws on T7 and T9 added on the basis of short segment fixation. The motions of each model in standing state were simulated in software. The range of motion (ROM) and internal fixation stress changes were analyzed.

Results
When anterior support was effective, the three fixation methods could effectively maintain the stability of the spine. However, when anterior support failed, the ROM of the long segment fixation group and the short segment fixation group in the flexion-extension directions was significantly higher than that of when the anterior support existed, while the modified short segment fixation group had no significant changes. Meanwhile, the stress of internal fixation in the long segment fixation group and the short segment fixation group were greatly increased. However, there were no significant changes in modified short segment fixation group.

Conclusion
After TES, the presence of the thoracic cage gives partial anterior stabilization. When the anterior support failed, the modified short segment fixation method can provide better stability.
The biomechanical effect of different posterior tibial slopes on the tibiofemoral joint after posterior-stabilized total knee arthroplasty
Authors: Wang Yingpeng , Yan Songhua , Zeng Jizhou , Zhang Kuan 
Published: August 2020

AbstractBackgroundDifferent posterior tibial slopes (PTS) after posterior-stabilized total knee arthroplasty (PS-TKA) may lead to different biomechanical characteristics of knee joint. This cadaveric study was designed to investigate the tibiofemoral kinematics and contact pressures after PS-TKA with different PTS.MethodsNine human cadaveric knee specimens were used for PS-TKA with the PTS of 3°, 6°, and 9°. The tibiofemoral kinematics and contact pressures were measured during knee flexion angle changing from 0 to 120° (with an increment of 10°) with an axial load of 1000 N at each angle.ResultsThe root mean square (RMS) of the tibiofemoral contact area and the mean and peak contact pressures during knee flexion were 586.2 mm2, 1.85 MPa, and 5.39 MPa before TKA and changed to 130.2 mm2, 7.56 MPa, and 17.98 MPa after TKA, respectively. Larger contact area and smaller mean and peak contact pressures were found in the joints with the larger PTS after TKA. The RMS differences of femoral rotation before and after TKA were more than 9.9°. The posterior translation of the lateral condyle with larger PTS was more than that with smaller PTS, while overall, the RMS differences before and after TKA were more than 11.4 mm.ConclusionAfter TKA, the tibiofemoral contact area is reduced, and the contact pressure is increased greatly. Approximately 80% of the femoral rotation is lost, and only about 60% of the femoral translation of lateral condyle is recovered. TKA with larger PTS results in more posterior femoral translation, larger contact area, and smaller contact pressure, indicating that with caution, it may be beneficial to properly increase PTS for PS-TKA.