bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yeast as major protein‐rich ingredient in aquafeeds: a review of the implications for aquaculture production
Authors: Agboola Jeleel Opeyemi , Øverland Margareth , Skrede Anders , Hansen Jon Øvrum 
Published: September 2020

AbstractSustainability concerns associated with protein sources and currently used fishmeal and plant‐based meal have necessitated the quests for novel sustainable ingredients for use in aquafeeds. Yeasts have been proposed as sustainable ingredients particularly because of their potential to valorise non‐food lignocellulosic biomass into valuable protein resources. Prior to now, extensive studies exist on the role of yeast cell wall components in modulating health responses of fish. However, research on its use as a major protein source in fish diets is still in its infancy. The current review collates, synthesises and discusses the prospects of five major yeast species as future protein ingredients with respect to their nutritional adequacy in fish. Nutritional quality of Saccharomyces cerevisiae, Cyberlindnera jadinii, Kluyveromyces marxianus, Blastobotrys adeninivorans and Wickerhamomyces anomalus and their use as replacement for fishmeal and soy protein in the diets of Atlantic salmon and rainbow trout are discussed based on three protein quality indices: chemical score, essential amino acid index and ideal protein concept based on the first limiting amino acids, methionine. The crude protein contents of yeast (40–55%) are lower than that of fishmeal, but comparable with soya bean meal. Compared to fishmeal, the different yeast species have favourable amino acid profiles, except for methionine, lysine, arginine and phenylalanine which are the frequently limiting essential amino acids in Atlantic salmon and rainbow trout. This review also presents future area of research and emphasise the need for large‐scale production of yeast at competitive price to constitute a feasible replacement for fishmeal and soy protein in aquaculture.
Degenerate Bogdanov–Takens bifurcations in a bulk viscous cosmology
Authors: Azim Asmaa Abdel , Awad Adel , Lashin E. I. 
Published: September 2020

AbstractUsing the dynamical system theory we show that the Friedmann–Robertson–Walker (FRW) cosmological model with bulk viscous fluid in the presence of cosmological constant is equivalent to a degenerate two dimensional Bogdanov–Takens normal form. The equation of state parameter, $$\omega $$
ω
, the bulk viscosity coefficient, $$\xi $$
ξ
, and the cosmological constant, $$\Lambda $$
Λ
, define the necessary parameters for unfolding the degenerate Bogdanov-Takens system. The fixed points of the system are discussed together with the variation of their stability properties upon changing the relevant parameters $$\omega , \Lambda $$

ω
,
Λ

and $$\xi $$
ξ
. The variation of the stability properties are visualized by the appropriate bifurcation diagrams. Phase portrait for finite domain and global phase portrait are displayed and the issue of the structural stability is discussed. Typical issues such as late acceleration or inflation that can be induced by viscosity and could have relevance to observational cosmology are also discussed.
Incidence of uveitis and macular edema among patients taking fingolimod 0.5 mg for multiple sclerosis
Authors: Sonne Scott Joseph , Smith Bradley Thomas 
Published: September 2020

Abstract
Background
Patients with multiple sclerosis (MS) have a higher incidence of uveitis compared with the general population. Fingolimod, a first line disease modifying drug used in multiple sclerosis, may cause macular edema and thus requires ophthalmic examination. However, murine models and anecdotal reports suggest fingolimod may reduce the incidence of uveitis.

Purpose
To report the incidence of uveitis and macular edema among those on fingolimod 0.5 mg (Gilenya®) therapy for multiple sclerosis (MS).

Methods
Retrospective review of patients on fingolimod who developed uveitis and/or macular edema.

Results
No patients had an occurrence or history of uveitis. Four of the 188 (2.13%) patients developed macular edema without ocular inflammation. One of the 188 (0.53%) patients developed Acute Macular Neuroretinopathy.

Conclusion
Patients taking fingolimod have a lower incidence of uveitis than expected in a population of MS patients.
Phaeoacremonium species detected in fine needle aspiration: a rare case report
Authors: Tummidi Santosh , Naik Bitan , Shankaralingappa Arundhathi , Balakrishna Pavithra , Bhadada Arati Ankushrao , Kosaraju Navya 
Published: September 2020

Abstract
Background
Fine needle aspiration cytology (FNAC) with rapid on-site evaluation has a great potential for the diagnosis of fungal lesions and other opportunistic infections. Fungal infections have been in increasing trend in the past two decades due to immunosuppression, travel, and environmental exposure. Human disease caused by Phaeoacremonium species is rare and was first reported in 1974 as subcutaneous tissue infection in a renal transplant recipient.

Case presentation
We report a case of subcutaneous tissue swelling in a 67-year-old male, wherein FNAC was done with incidental detection of the fungus (Phaeoacremonium spp).

Conclusion
There are very few reported cases of subcutaneous infection in humans by Phaeoacremonium spp. Clinical suspicion and FNAC can play an important role in early detection of the fungus, prevent spread, and facilitating early treatment.
What is the impact of patient recruitment on offshoring of clinical trials?
Authors: Kermanimojarad Maryam 
Published: September 2020

AbstractThe issue of globalization of research is receiving considerable attention due to the increasing number of offshored R&D activities from the United States, Europe, and Japan. This paper explores this phenomenon and provides a model to analyze the factors that will likely contribute to a global transformation of clinical trials. By identifying the main characteristics of clinical trials, I aim to clarify the main driver of the relocation process of clinical research. I reviewed the relevant published articles to address the research questions. The results of this study challenge the traditional thinking of cost-related factors as the major reason for offshoring cilinical trials and show the importance of the recruitment of human subjects in trials. Consequently, this paper suggests that “recruitment crisis” in home country as the main contribution and a key driver to offshore R&D activities, has been underestimated by previous studies. In particular, this study provides policy-decision makers with a new insight into the development issue surrounding the pharmaceutical industry.
The online attention to orthodontic research: an Altmetric analysis of the orthodontic journals indexed in the journal citation reports from 2014 to 2018
Authors: Garcovich Daniele , Zhou Wu Angel , Sanchez Sucar Ana-Matilde , Adobes Martin Milagros 
Published: September 2020

Abstract
Background
To describe the impact of research, beyond the limits of the academic environment, Altmetric, a new social and traditional media metric was proposed. The aims of this study were to analyze the online activity related to orthodontic research via Altmetric and to assess if a correlation exists among citations, Mendeley reader count, and the AAS (Altmetric Attention Score).

Method
The Dimensions App was searched for articles published in the orthodontic journals listed in the Journal Citation Reports (JCR) throughout the years 2014 to 2018. The articles with a positive AAS were collected and screened for data related to publication and authorship. The articles with an AAS higher than 5 were screened for research topic and study design. Citation counts were harvested from Web of Science (WOS) and Scopus.

Results
The best performing journals were Progress in Orthodontics and the European Journal of Orthodontics with a mean AAS per published item of 1.455 and 1.351, respectively and the most prevalent sources were Tweets and Facebook mentions. The most prevalent topic was Oral Health-Related Quality of Life (OHRQOL) and the study design was systematic reviews. The correlation between the AAS and the citations in both WOS and Scopus was poor (r = 0.1463 and r = 0.1508, p < .05). The correlation between citations count and Mendeley reader (r = 0.6879 and r = 0.697, p < .05) was moderate.

Conclusions
Few journals displayed a high level of web activity. Journals and editors should enhance online dissemination of the scientific outputs. The authors should report the impact of the findings to the general public in a convenient way to facilitate online dissemination but to avoid an opportunistic use of the research outputs. Despite the lack of correlation, a combination of the citation count and the AAS can give a more comprehensive assessment of research impact.
Patient insights on living with idiopathic inflammatory myopathy and the limitations of disease activity measurement methods – a qualitative study
Authors: Oldroyd Alexander , Dixon William , Chinoy Hector , Howells Kelly 
Published: September 2020

Abstract
Background
The idiopathic inflammatory myopathies (IIMs) are chronic autoimmune conditions, typically resulting in proximal muscle weakness and impacting upon quality of life. Accurate measurement of IIM disease activity is imperative for appropriate medical management and carrying out valid clinical trials. The International Myositis Assessment and Clinical Studies Group (IMACS) “Disease Activity Core Set Measures” are the current gold-standard of IIM disease activity assessment. Anecdotally, patients with an IIM report that the IMACS Core Set Measures and other available methods do not necessarily capture their perceived disease activity. Investigating the patient experiences of living with an IIM and their views on the accuracy of the IMACS Core Set Measures will provide valuable insights for both clinical and research purposes.

Methods
Eighteen interviews with patients with an IIM were carried out and analysed thematically, using a grounded theory approach. Experiences on living with an IIM and perceptions on the accuracy of disease activity measurement methods were explored.

Results
Interview analysis revealed four themes: 1) fatigue, 2) pain, 3) day-to-day symptom variation, 4) limitations of creatine kinase levels and manual muscle testing.

Conclusions
This study has provided valuable insights into patient experiences of living with an IIM. Aspects of IIM disease activity perceived not to be wholly measured by the IMACS Core Set Measures have also been identified. These findings have implications for future IIM clinical care and research, in particular providing justification for research into pain, fatigue and symptom variation.
Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline
Authors: Newman Connie B , Blaha Michael J , Boord Jeffrey B , Cariou Bertrand , Chait Alan , Fein Henry G , Ginsberg Henry N , Goldberg Ira J , Murad M Hassan , Subramanian Savitha , Tannock Lisa R 
Published: September 2020

AbstractObjectiveThis guideline will provide the practicing endocrinologist with an approach to the assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of preventing cardiovascular (CV) events and triglyceride-induced pancreatitis. The guideline reviews data on dyslipidemia and atherosclerotic cardiovascular disease (ASCVD) risk in patients with endocrine disorders and discusses the evidence for the correction of dyslipidemia by treatment of the endocrine disease. The guideline also addresses whether treatment of the endocrine disease reduces ASCVD risk.ConclusionThis guideline focuses on lipid and lipoprotein abnormalities associated with endocrine diseases, including diabetes mellitus, and whether treatment of the endocrine disorder improves not only the lipid abnormalities, but also CV outcomes. Based on the available evidence, recommendations are made for the assessment and management of dyslipidemia in patients with endocrine diseases.
Peran Pemerintah Desa Dalam Perubahan Pariwisata Osing Di Desa Kemiren Kecamatan Glagah Kabupaten Banyuwangi
Authors: Murdyastuti Anastasia , Mayasiana Nur Aini 
Published: September 2020

Abstract
Banyuwangi Regency is actively developing tourism potential, one of which is osing culture because it is unique and exciting as part of osing community life which is very obedient and obedient to cultural values. Still, the osing community is dynamic so that the existence of osing culture which was only as a traditional ceremonial tradition, is now packaged into more interesting material that can be a spectacle that can be sold. The change is inseparable from the role of the village government to invite the public and the private sector to jump into more advanced conditions and even become a leading tourism object in Banyuwangi Regency. The research method used is qualitative, and data collection techniques by observation, documentation, and interviews — analysis of data with interactive models through data collection data presentation data reduction and concluding. The results showed that the role of the government in making changes was quite good as seen from changes in tourist attractions and attractions, amenities and accommodation, accessibility, and tourism image osing already adequate, complete and good condition, because of the similarity in seeing the same future in advancing its village, trusting and making changes with specific actions between the private government and the community, although there are still limited funds and differences in interests, the government provides consistent support and basis so as to demonstrate a mutually supporting synergy.
Keyword: Role, village government, change, and tourism osin
PENGGUNAAN DATA AIS-IRSMS UNTUK PREDIKSI KECELAKAAN MELIBATKAN SEPEDA MOTOR PADA RUAS JALAN DI KOTA SURABAYA
Authors: Arifin Muhammad Zainul , Agustin Imma Widyawati , Sulistyono Sonya 
Published: September 2020

Accidents of involving motorcycles in Surabaya tend to increase. Recorded from 2014 to 2016 were reached 721, 929 and 1,325 accidents. This phenomenon is certainly not beneficial for the community and road transport policy makers. This study was conducted to determine the characteristics of motorcycle riders and accidents of involving motorcycles. This research further develops estimation of accident prediction involving motorcycle in Surabaya City. Accident data compiled from AIS-IRSMS to know the characteristics of users and accidents using the accidents approach. The research location was conducted in accident prone areas during January 2014 to February 2017 also using AIS-IRSMS. With the Generalized Linear Models (GLMs), the result of estimation of accident estimation involving motorcycle that is McA = 0.00225 Q1.030 e(0.034 S). Accidents of involving motorcycles are heavily influenced by the number of vehicles on the road and the speed of the vehicle.
Kecelakaan melibatkan sepeda motor di Kota Surabaya cenderung mengalami peningkatan. Tercatat tahun 2014 hingga 2016 mencapai 721, 929 dan 1.325 kejadian kecelakaan. Fenomena ini tentunya tidak menguntungkan bagi masyarakat dan pengambil kebijakan terkait transportasi jalan raya. Penelitian ini dilakukan untuk mengetahui karakteristik pengendara sepeda motor terlibat kecelakaan dan kecelakaan melibatkan sepeda motor. Lebih lanjut penelitian ini melakukan pengembangan estimasi prediksi kecelakaan melibatkan sepeda motor di Kota Surabaya. Data kecelakaan dikompulir dari AIS-IRSMS untuk mengetahui karakteristik penguna dan kecelakaan menggunakan pendekatan frekwensi kejadian. Lokasi penelitian dilakukan pada daerah rawan kecelakaan sepanjang Januari 2014 hingga Februari 2017 juga menggunakan bantuan AIS-IRSMS. Menggunakan metode Generalized Linear Models (GLMs), hasil penelitian diperoleh estimasi prediksi kecelakaan melibatkan sepeda motor yaitu McA= 0,00225 Q1,030 e(0,034 S). Kecelakaan melibatkan sepeda motor sangat dipengaruhi oleh banyaknya kendaraan di jalan dan kecepatan kendaraan.
MOTIF PEREMPUAN BERKENDARA SEPEDA MOTOR TANPA HELM: STUDI KASUS DI KOTA SIDOARJO, JAWA TIMUR
Authors: Rifai Irvan , Santoso Fajar 
Published: September 2020

This case study is aimed at revealing motives of women riding motor bike without helmet in Sidoarjo, East Java. The data in this study are garnered through interviews, focus group discussions, observation, and artefact including online newspapers, whilst thematic analysis is utilised as a primary data analysis. The findings of the study indicate that; first, distance from home to school is a most salient motive of women riding bike without helmet. Second, the absence of policeman on the street is a key factor of not wearing helmet. Third, social identity is another reason for not wearing helmet. Fourth, styles and its influence of feeling discomfort of wearing helmet. Fifth, social rules and its impracticality of not wearing helmet. The findings of this study are expected to have contributions of the ways to educate people about safety riding by involving students, students’ parents, teachers and or stakeholders. This study, however, cannot represent all women perspectives of not wearing helmet when riding motor bike within Indonesia. Further research, therefore, is expected to consider areas and characteristics which might differ from the present study.
Penelitian ini bertujuan untuk mengungkap motif perempuan pengendara sepeda motor tanpa helm di daerah Kabupaten Sidoarjo, Jawa Timur, dengan menggunakan metode wawancara, Focus Group Discussion, observasi, dan analisis terhadap tulisan-tulisan yang ada di media sosial, seperti koran online. Analisis yang dilakukan menggunakan metode analisis tematik. Dari hasil analisis data diperoleh 5 tema yang menjadi pembahasan pada penelitian ini, yaitu: pertama, Jarak dari rumah ke sekolah menjadi pertimbangan utama responden tidak memakai helm; kedua, Kehadiran aparat kepolisian dan motif tidak memakai helm; ketiga, Identitas sosial sebagai alasan tidak memakai helm; keempat, style dan pengaruh ketidaknyamanan memakai helm; dan ke lima, aturan sosial dan ketidakpraktisan memakai helm. Hasil penelitian ini diharapkan bisa memberikan kontribusi informasi terhadap upaya mengedukasi masyarakat dalam keselamatan berkendara sepeda motor dengan melibatkan peran serta siswa, orang tua siswa, guru dan pemangku kepentingan. Namun demikian, dikarenakan penelitian ini terbatas pada studi kasus di Kota Sidoarjo, terdapat kemungkinan bahwa hasil yang diperoleh tidak dapat merepresentasikan perspektif perempuan pengendara sepeda motor di kota-kota lain di Indonesia. Untuk itu, penelitian ini diharapkan dapat dilanjutkan untuk kota-kota yang mempunya karakteristik berbeda dengan lokasi penelitian ini.
PENENTUAN SIMPANG BERSINYAL RAWAN KECELAKAAN UNTUK IDENTIFIKASI AWAL TERHADAP POTENSI RED LIGHT RUNNING (RLR) DI BANDA ACEH
Authors: Saleh Sofyan M. , Sugiarto Sugiarto , Handayani Endang 
Published: September 2020

Red Light Running (RLR) is the leading cause of traffic accidents at signal intersections in various countries, including Indonesia. The main reason is the existence of conflicts caused by drivers' behavioral factors who are not obedient or understand about signaling operations. RLR is the most dangerous driver's behavior in a signal intersection, where the driver fails to comply with signaling rules at the intersection so that the conflict occurs. To assess the behavior of the RLR, the first step is to identify the signaled intersections that are most prone to accidents. This is needed to eliminate the location of study or handling due to limited time and costs. The methodology used to determine accident-prone locations is based on the Highway Safety Improvement Program in the Highway Safety Manual (HSM, 2010), namely the planning component consisting of data collection and identification of accident-prone areas in signal intersections. Using accident data of 2013-2015, and by combining three methods of analysis such as frequency, accident rate, and equivalent property damage only methods, then three most accident-prone signal intersections are determined and prioritized for in-depth study of RLR behavior analysis.
Red Light Running (RLR) adalah penyebab utama kecelakaan lalu lintas pada simpang bersinyal di berbagai negara termasuk Indonesia. Penyebab utamanya adalah adanya konflik yang diakibatkan oleh faktor perilaku pengemudi yang tidak patuh atau paham tentang pengoperasian persinyalan. RLR merupakan perilaku pengemudi yang paling berbahaya pada simpang bersinyal, dimana pengemudi gagal mematuhi peraturan persinyalan pada simpang sehingga konflik terjadi. Untuk mengkaji perilaku pada RLR perlu dilakukan langkah awal yaitu identifikasi simpang bersinyal yang paling rawan terhadap kecelakaan. Hal ini diperlukan untuk mengeliminasi lokasi kajian atau penanganan akibat keterbatasan waktu dan biaya. Metodologi yang digunakan untuk penentuan lokasi rawan kecelakaan dilakukan mengacu pada Highway Safety Improvement Program di dalam Highway Safety Manual (HSM, 2010), yaitu planning component yang terdiri dari pengumpulan data dan identifikasi daerah rawan kecelakaan pada simpang bersinyal. Menggunakan data kecelakaan tahun 2013-2015 dengan mengombinasikan tiga metode analisis yaitu metode frekuensi, tingkat kecelakaan dan ekuivalensi kerugian harta benda (EPDO) ditentukan tiga simpang bersinyal yang paling rawan kecelakaan dan diprioritaskan untuk dilakukan kajian mendalam terhadap perilaku pelanggaran RLR.
Financial and nonfinancial factors affecting future cashflow and their impacts on financial distress
Authors: Safiq Muhamad , Selviana Rinda , Kusumastati Widyahayu Warmmeswara 
Published: September 2020

This study aimed to determine financial and non-financial factors influencing future cash flow and their impacts on company's financial distress. This study uses earnings, cash flow from operations, accrual components, working capital (financial), inflation (nonfinancial) as independent variables that are thought to have an effect on future cash flow. In addition, this research also suspects that there is an impact of this influence on company financial distress. The sample used in this study was 30 food and beverage manufacturing companies listed on the Indonesia Stock Exchange from 2013 to 2015. Hypothesis testing, in this research, used Structural Equation Model (SEM) method with AMOS 24 statistic. The result showed that earnings, accrual component, and working capital had a significant positive effect on future cash flow. Furthermore, cash flow from operation had significant negative effect on future cash flow, but inflation did not affect company's future cash flow. These results indicate that financial variables have a significant effect, both positive and negative, on the company's future cash flow. Meanwhile, non-financial variables have no significant effect. Other test resulted that future cash flow had a significant negative effect on financial distress. Based on the results of this study, it can be seen that stakeholders, especially investors, really pay attention to the company's financial performance compared to non-finance. This is due to the significant influence of financial variables on the company's future cash flow and it can have an impact on financial distress. Therefore, future research is expected to explore other financial factors that affect the company's future cash flow, for example, the company's financial risk.