bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precision Photometric and Astrometric Calibration Using Alternating Satellite Speckles
Authors: Sahoo Ananya , Guyon Olivier , Lozi Julien , Chilcote Jeffery , Jovanovic Nemanja , Brandt Timothy , Groff Tyler , Martinache Frantz 
Published: May 2020

Abstract
Photometric and astrometric calibration of high-contrast images is essential for the characterization of companions at small angular separation from their stellar host. The main challenge to performing accurate relative photometry and astrometry of high-contrast companions with respect to the host star is that the central starlight cannot be directly used as a reference, as it is either blocked by a coronagraphic mask or saturating the detector. Our approach is to add fiducial incoherent faint copies of the host star in the image plane and alternate the pattern of these copies between exposures. Subtracting two frames with different calibration patterns removes measurement bias due to static and slowly varying incoherent speckle halo components, while ensuring that calibration references are inserted on each frame. Each calibration pattern is achieved by high-speed modulation of a pupil-plane deformable mirror to ensure incoherence. We implemented the technique on-sky on the Subaru Coronagraphic Extreme Adaptive Optics instrument with speckles which were of the order of 103 times fainter than the central host. The achieved relative photometric and astrometric measurement precisions for 10 s exposure were respectively 5% and 20 milliarcsecond. We also demonstrate, over a 540 s measurement span, that residual photometric and astrometric errors are uncorrelated in time, indicating that residual noise averages as the inverse square root of the number of exposures in longer time-series data sets.
Curious Changes in Association of Complex Sunspot Groups with X-Ray Flares (≥M1) in Solar Cycles 22–24
Authors: Gao P. X. 
Published: May 2020

Abstract
We investigate the variations in the probabilities of complex sunspot groups (SGs)—large, asymmetric, or δ-type SGs—producing X-ray flares (≥M
1) in solar cycles (SCs) 22, 23, and 24 based on the SG data collected by the United States Air Force/Mount Wilson Observatory and the flare data recorded by Geostationary Operational Environmental Satellites. The following are the main findings. (1) For complex SGs in the whole disk as well as the northern and southern hemispheres during SC 22, their numbers and probabilities of producing flares change almost synchronously. (2) For complex SGs during SC 23, probabilities of producing flares during the early declining phase in the whole disk do not decrease with decreasing complex SG number; in the northern hemisphere, the probability of producing flares during the declining phase is significantly higher than that during the maximum phase; in the southern hemisphere, there is no definite variation trend in the probabilities of producing flares during the maximum and declining phases. (3) For complex SGs during SC 24, the probabilities of producing flares during the later rising and early declining phases are significantly higher than or comparable to those during the maximum phase no matter how their numbers change; in the northern hemisphere, the probability of producing flares during the rising phase is significantly higher than or at least comparable to that during the maximum phase; in the southern hemisphere, there is no definite variation trend in the probabilities of producing flares during the maximum and declining phases.
Lessons Learned From Medical Malpractice Claims Involving Critical Care Nurses
Authors: Myers Laura C. , Heard Lisa , Mort Elizabeth 
Published: May 2020

BackgroundMedical malpractice data can be used to improve patient safety.ObjectiveTo describe the types of harm events involving nurses that lead to malpractice claims and to compare claims among intensive care units (ICUs), emergency departments, and operating rooms.MethodsMalpractice claims closed between 2007 and 2016 were extracted from a national database. Claims with a nurse as the primary provider were identified and then compared by location of the harm event: ICU, emergency department, or operating room. Multivariable regression was used to determine predictors of claims payment.ResultsOf 54 699 claims, 314 involved ICU nurses as the primary provider. The majority (59%) of claims involving ICU nurses resulted in death or permanent injury. The most common allegation of claims involving ICU nurses was failure to monitor (47%), which was higher than among claims against nurses in the emergency department (9%) or the operating room (4%) (P &lt; .001). The most common diagnosis in claims involving ICU nurses was decubitus ulcers (26%). Despite equivalent numbers of defendants per claim, the median indemnity for paid claims involving ICU nurses was higher ($125 000) than that paid for claims originating in the emergency department ($56 799) or operating room ($43 910) (P &lt; .001). In multivariable regression, 2 variables increased the risk of claim payment: ICU location (odds ratio, 1.79 [95% CI, 1.29-2.48]) and permanent injury (odds ratio, 1.50 [95% CI, 1.07-2.09]).ConclusionsMalpractice claims involving ICU nurses were distinct from claims in comparably fast-paced settings. Focusing harm-prevention efforts in the ICU on skin integrity and monitoring of patients would most likely mitigate many highly severe harms involving ICU nurses, which would benefit both patients and nurses.
Religie op het werk?
Authors: Franken Leni , Levrau François 
Published: May 2020

Religie op het werk? Over positieve en negatieve godsdienstvrijheid bij private ondernemingen en tendensondernemingen
In this article we elaborate on the place of religion in the workplace. Does the individual freedom of religion imply that employers must always accommodate the religious claims of employees or can they boast a number of arguments allowing them to legitimately limit that freedom? And, conversely, do employers not also have a right to freedom of religion and a right to formulate certain religious expectations for their employees? In this contribution, we deal with these and related questions from a legal-philosophical perspective. The overall aim is to illustrate the extent to which univocal answers are jeopardized because of conceptual ambiguities. We first make a normative distinction between two strategies (i.e. difference-blind approach and difference-sensitive approach) and subsequently illustrate and elaborate on how and why these strategies can lead to different outcomes in legal cases. We illustrate the extent to which a contextual and proportional analysis can be a way out in theoretical and practical conundrums.
Yuelushannus gen. nov. (Araneae, Linyphiidae) from China
Authors: Irfan Muhammad , Zhou Gu-chun , Bashir Shahida , Mukhtar Muhammad Khalid , Peng Xian-jin 
Published: May 2020

The new erigoninae genus Yuelushannus gen. nov. with two new species, Y. alatus sp. nov. (♂♀) and Y. barbatus sp. nov. (♂♀), are described from Hunan and Hubei Provinces. Detailed descriptions of somatic features and genitalic characters, photos of the habitus and copulatory organs, line drawings of copulatory organs and a distribution map are provided.
Cubic spline interpolation based estimation of all story seismic responses with acceleration measurement at a limited number of floors
Authors: Kodera Kenzo , Nishitani Akira , Okihara Yurina 
Published: May 2020

AbstractBuilding damage assessment soon after a seismic event is a highly significant issue. Currently, sensor implementation on all the floors of a building comprising more than a few stories is not practical. This paper proposes a framework for estimating the responses of all the stories of buildings, only using data from a limited number of accelerometers. Based on cubic spline interpolation, the framework is constructed by setting of the boundary conditions at the top and the base of the building. The validity of the framework is demonstrated utilizing the E‐defense shake table test data.
Melatonin‐Based and Biomimetic Scaffold as Muscle–ECM Implant for Guiding Myogenic Differentiation of Volumetric Muscle Loss
Authors: Xu Yang , Chen Xuan , Qian Yun , Tang Haozheng , Song Jialin , Qu Xinhua , Yue Bing , Yuan Wei‐En 
Published: May 2020

AbstractVolumetric muscle loss (VML) caused by injury or trauma affects the quality of life directly, due to its high incidence, lingering healing, and prolonged duration. Tissue engineered scaffolds have been widely used in muscle regeneration for patients with massive muscle injury. Melatonin (MLT) is a bioactive substance secreted by the pineal gland, which can promote muscle recovery by inhibiting oxidative stress and inflammation. Herein, a biocompatible scaffold is developed using thiolated hyaluronic acid (HA‐SH), collagen I (COL I), and polycaprolactone/melatonin (PCL/MLT) electrospun membranes. This scaffold mimics extracellular matrix (ECM) and architectural features of native muscle, possesses appropriate mechanical property, stiffness and promotes vascularization. It can provide adhesion sites for C2C12 cells and induce their proliferation and differentiation. Moreover, VML rat model is established to evaluate its effect on muscle regeneration. Results demonstrate that this scaffold possesses a practical application for VML.
Scaffold‐Free Bio‐3D Printing Using Spheroids as “Bio‐Inks” for Tissue (Re‐)Construction and Drug Response Tests
Authors: Murata Daiki , Arai Kenichi , Nakayama Koichi 
Published: May 2020

AbstractIn recent years, scaffold‐free bio‐3D printing using cell aggregates (spheroids) as “bio‐inks” has attracted increasing attention as a method for 3D cell construction. Bio‐3D printing uses a technique called the Kenzan method, wherein spheroids are placed one‐by‐one in a microneedle array (the “Kenzan”) using a bio‐3D printer. The bio‐3D printer is a machine that was developed to perform bio‐3D printing automatically. Recently, it has been reported that cell constructs can be produced by a bio‐3D printer using spheroids composed of many types of cells and that this can contribute to tissue (re‐)construction. This progress report summarizes the production and effectiveness of various cell constructs prepared using bio‐3D printers. It also considers the future issues and prospects of various cell constructs obtained by using this method for further development of scaffold‐free 3D cell constructions.
Using deep learning to recognize liquid–liquid flow patterns in microchannels
Authors: Shen Chong , Zheng Qibo , Shang Minjing , Zha Li , Su Yuanhai 
Published: May 2020

AbstractIn this work, an automatic liquid–liquidtwo‐phase flow pattern recognition platform was developed to help circumvent the difficulties in labor‐intensive hydrodynamics studies. Trained by about 30,000 of human‐labeled flow pattern images, a convolutional neural network was built with the expert‐level ability in the flow pattern recognition tasks and then coupled with automatic pump feeding system and online high‐speed camera monitoring system to realize the high‐throughput experimentation platform for microchannels. Effects of important factors such as flow rate, viscosity, interfacial tension, and so on were studied, and different flow pattern maps were obtained. With these thousands of flow pattern data in hand, we eventually drew the generalized liquid–liquidtwo‐phase flow map and then proposed the relatively prudent criteria for slug flow operation window in the microchannel. This study extended the applications of artificial intelligence on microreactor technology or microfluidics, and in particular facilitated understanding complex hydrodynamics and flow patterns.
Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides
Authors: Mo Xueling , Chen Bin , Zhang Guozhu 
Published: May 2020

AbstractAn asymmetric copper‐catalyzed Sonogashira type coupling between alkynes and α‐bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ‐alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .
Properties of Coated Controlled Release Diammonium Phosphate Fertilizers Prepared with the Use of Bio‐based Amino Oil
Authors: Sofyane Asma , Lahcini Mohammed , El Meziane Abdellatif , Khouloud Mehdi , Dahchour Abdelmalek , Caillol Sylvain , Raihane Mustapha 
Published: May 2020

AbstractIn an effort to enhance the efficiency of fertilizer use and minimize their negative impact on the environment, a novel biomass‐based, functional controlled‐release fertilizer was used to improve nutrient use efficiency and increase crop production systems for more sustainable agriculture practices. Here, bio‐based amino‐oil (Priamine) mixtures were proposed as an outer coating with different layers for the control of phosphorus release from diammonium Phosphate (DAP). These hydrophobic coatings conferred excellent barrier properties and flexibility to coatings. The morphological characterization of the coated fertilizer was performed by scanning electronic microscopy (SEM), electronic diffraction X‐ray (EDX) and mapping, and revealed the formation of a cohesive film and a good adhesion between DAP fertilizer and coating film. The release rate of nutrients (phosphate) in water was investigated by UV–Vis spectrophotometer. The effect of coating thickness was investigated on release time and diffusion coefficient of phosphor release in distilled water. Release time increased with the coating thickness. The diffusion coefficient of nutrient release decreased with the coating thickness. Compared with uncoated granule which is totally solubilized after less than 2 hours, the P release profiles of the coated granules reached the equilibrium stage approximately after 98 and 126 hours when the DAP is coated with only Priamine single‐layer (1L) and double‐layer (2L), respectively. Moreover, the strategy adopted has successfully provided a very slow release and long‐term availability of nutrient sources with bio‐based coating oil compared to uncoated fertilizer (DAP) and therefore exhibited promising application for sustainable development of modern agriculture and circular economic.
Clinical relevance of the anatomy of the long head bicipital groove, an evidence‐based review
Authors: van Deurzen Derek F. P. , Garssen Frans L. , Kerkhoffs Gino M. M. J. , Bleys Ronald L. A. W. , ten Have Isha , van den Bekerom Michel P. J. 
Published: May 2020

AbstractPathology in the bicipital groove can be a source of anterior shoulder pain. Many studies have compared treatment techniques for the long head biceps tendon (LHBT) without showing any clinically significant differences. As the LHBT is closely related to the bicipital groove, anatomical aspects of this groove could also be implicated in surgical outcomes. The aim of this review is to contribute to developing the optimal surgical treatment of LHBT pathology based on clinically relevant aspects of the bicipital groove. Medline/PubMed was systematically searched using key words “bicipital” and “groove” and combinations of their synonyms. Studies reporting on evolution, embryonic development, morphometry, vascularization, innervation, and surgical treatment of the LHBT and the bicipital groove were included. The length of the bicipital groove reported in the included studies ranged from 81.00 mm to 87.33 mm, width from 7.74 mm to 11.60 mm, and depth from 3.70 mm to 6.00 mm. The anatomy of the bicipital groove shows a bottleneck narrowing approximately two‐thirds from superior. The transverse humeral ligament can constrain the bicipital groove and could be involved in anterior shoulder pain. When either LHBT tenotomy or tenodesis is performed, routinely releasing the transverse ligament could decrease postoperative anterior shoulder pain, which has frequently been reported in the literature. To avoid the bottle neck narrowing, a location below the bicipital groove may be preferred for biceps tenodesis over a more proximal tenodesis site.Level of evidence: IV.
Albert C. Broders, tumor grading, and the origin of the long road to personalized cancer care
Authors: Wright James R. 
Published: May 2020

AbstractThe roots of precision cancer therapy began at the Mayo Clinic in 1914 when surgical pathologist Albert C. Broders began collecting data showing that cancers of the same histologic type behaved differently. In March 1920, based upon 6 years of clinical follow‐up, Broders published his first paper, utilizing data from over 500 cases of squamous cell carcinoma of the lip that he had blindly divided into four histologic grades based upon degree of differentiation, showing that numerical tumor "grading" allowed him to predict patient prognosis. Before this, surgeons had no scientific way to evaluate prognosis. Broders then replicated his work using other types of tumors at other body sites, as did several Mayo Fellows and pathologists at other institutions. Cuthbert Dukes in London, England not only replicated Broders’ findings with rectal adenocarcinomas, he also used the same data to develop the first tumor “staging” methodology by focusing upon depth of local invasion and presence or absence of lymph node metastases. Soon, tumor grading, tumor staging, or the combination of both represented state‐of‐the‐art prognostic techniques for scientific cancer care. This brief historical vignette celebrates the 100th anniversary of Broders’ first paper, which is the starting point for the long road to personalized cancer care.
Second‐line treatment of hepatocellular carcinoma after sorafenib: Characterizing treatments used over the past 10 years and real‐world eligibility for cabozantinib, regorafenib, and ramucirumab
Authors: Fung Andrea S. , Tam Vincent C. , Meyers Daniel E. , Sim Hao‐Wen , Knox Jennifer J. , Zaborska Valeriya , Davies Janine , Ko Yoo‐Joung , Batuyong Eugene , Samawi Haider , Cheung Winson Y. , Lee‐Ying Richard 
Published: May 2020

AbstractBackgroundThe CELESTIAL, RESORCE, and REACH‐2 trials showed survival benefit of cabozantinib, regorafenib, and ramucirumab, respectively, in hepatocellular carcinoma (HCC) patients treated with sorafenib who had good performance status (ECOG 0‐1) and liver function (Child‐Pugh‐A). This study characterizes subsequent treatments received by HCC patients after sorafenib, and determines the proportion of patients eligible for novel therapies if strict eligibility criteria (SEC) were utilized compared to more liberal modified eligibility criteria (MEC, including ECOG 2, Child‐Pugh‐B7).MethodsHCC patients who received sorafenib between 2008 and 2017 were included from the Canadian HCC CHORD Database. Patients were classified as eligible or ineligible based on available CELESTIAL, RESORCE, and REACH‐2 trial SEC or MEC. Median overall survival (mOS) was assessed using the Kaplan‐Meier method.ResultsA total of 730 patients were identified; and 172 (23.6%) received subsequent treatment. Patients who received subsequent treatment had longer mOS than those who did not (12.1 vs 3.3 months; P < .001). Using SEC, only 13.1% of patients would be eligible for cabozantinib, regorafenib, or ramucirumab. Expanding eligibility to include patients who meet MEC increased the proportion of eligible patients to 31.7%. Higher ineligibility for regorafenib and ramucirumab was driven by trial‐specific criteria, including sorafenib intolerance (28%) for RESORCE and AFP <400 (58.9%) for REACH‐2.ConclusionsA small proportion of real‐world HCC patients would be eligible for cabozantinib, regorafenib, or ramucirumab if SEC in clinical trials were followed, while more than double would be eligible if MEC were applied. Patients who received subsequent treatment had improved mOS, regardless of whether they met SEC or MEC.
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains
Authors: Tietze Andreas , Shi Yan‐Ni , Kronenwerth Max , Bode Helge B. 
Published: May 2020

AbstractNonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones.
Nanoflower‐like Cu/SiO2 Catalyst for Hydrogenation of Ethylene Carbonate to Methanol and Ethylene Glycol: Enriching H2 Adsorption
Authors: Zhang Mengjiao , Yang Youwei , Li Antai , Yao Dawei , Gao Yueqi , Fayisa Busha Assaba , Wang Mei‐Yan , Huang Shouying , Lv Jing , Wang Yue , Ma Xinbin 
Published: May 2020

AbstractThe hydrogenation of ethylene carbonate (EC) to produce methanol and ethylene glycol (EG) is one of the key steps in the promising route for CO2 utilization on a large scale. However, the high H2/EC ratio in feed (usually as 200∼300) is generally required to achieve favorable catalytic activity, inducing the high cost for H2 circulation in the industrial application. Here, we report a series of nanoflower‐like catalysts with curved fibers and open ends, among which the catalyst with the highest fiber density exhibited nearly 98 % EC conversion, 75 % methanol selectivity and over 99 % EG selectivity when the H2/EC ratio was decreased to 60. Combining the characterizations of active species distribution and high‐pressure H2 adsorption, it is demonstrated that the nanoflower‐like morphology with dense fibers could remarkably enrich the hydrogen adsorption, consequently, accelerate the reaction rate and present an excellent performance at a low H2/EC ratio. These insights may provide instructive suggestions for further design of catalysts for the hydrogenation reactions.
Controllable synthesis of Fe–N4 species for acidic oxygen reduction
Authors: Yan Xuecheng , Jia Yi , Wang Kang , Jin Zhao , Dong Chung‐Li , Huang Yu‐Cheng , Chen Jun , Yao Xiangdong 
Published: May 2020

AbstractControllable design and synthesis of catalysts with the target active sites are extremely important for their applications such as for the oxygen reduction reaction (ORR) in fuel cells. However, the controllably synthesizing electrocatalysts with a single type of active site still remains a grand challenge. In this study, we developed a facile and scalable method for fabricating highly efficient ORR electrocatalysts with sole atomic Fe–N4 species as the active site. Herein, the use of cost‐effective highly porous carbon as the support not only could avoid the aggregation of the atomic Fe species but also a feasible approach to reduce the catalyst cost. The obtained atomic Fe–N4 in activated carbon (aFe@AC) shows excellent ORR activity. Its half‐wave potential is 59 mV more negative but 47 mV more positive than that of the commercial Pt/C in acidic and alkaline electrolytes, respectively. The full cell performance test results show that the aFe@AC sample is a promising candidate for direct methanol fuel cells. This study provides a general method to prepare catalysts with a certain type of active site and definite numbers.