bluuebunny/crossref_metadata_2025_split huggingface dataset:
Omgevingsvisies: een waarborg voor het religieus erfgoed?
Authors: Stevenson Lars , Honingh Marlies 
Published: September 2020

Environmental visions: a safeguard for the religious heritage?
After a year’s delay, the new Dutch Environmental Act will enter into force on January 1, 2022. Within this new legal framework, municipalities are expected to develop an environmental vision through policy integration and citizen participation. This new working method raises some questions. This article focuses on the quality of policy considerations with regard to vulnerable spatial domains and in particular religious heritage. It answers the question about the quality of policy considerations in municipal environmental visions and then examines whether policy integration and participation have contributed to this. An analysis of 33 municipal environmental visions shows that the quality of policy considerations for religious heritage is low in almost all municipalities. Interviews with nine municipalities provide a more complete picture and make it clear that the real quality of the policy considerations is higher than what can ultimately be found in the visions. However, these findings raise doubts about the future protection of the religious heritage in the further elaboration of the environmental vision in the environmental plan. In connection with this, two calls are made: (a) as a municipality, ensure that the subject of cultural heritage is on the political-administrative agenda; (b) ensure that cultural heritage is not only part of history, but also of the future.
De ‘archipelisering’ van Frankrijk: ook in Nederland?
Authors: Nelissen Nico 
Published: September 2020

The ‘archipelisation’ of France: also in the Netherlands?
This essay discusses the book L’archipel français: naissance d’une nation multiple et divisée. In addition, the French author Jérôme Fourquet is discussed, what the central thesis of the book is, what research methods the author uses, how the book is structured and what conclusions he comes to. Subsequently, the second part of the essay raises the question of the extent to which (in the opinion of the author of the essay) there is also a metamorphosis of society in the Netherlands, as is seen in France. This enables him, among other things, to report on a longitudinal research project at Radboud University Nijmegen, which is known as ‘Socio-cultural Developments in the Netherlands’ (SOCON). The central proposition of the bestseller is that France was once a nation that could be seen as ‘one and indivisible’ (and was experienced as such), but that France has changed fundamentally over the past decades and is now a ‘multiform and divided’ country: an ‘archipelisation’ process has occurred. Fourquet derives the term ‘archipelago’ from geology and uses it as a metaphor for the sub-worlds that have emerged: largely autonomous ‘islands’ with a limited joint bond. The Dutch SOCON study and other evidence supports Fourquet’s notion that there is also a huge shift in society in the Netherlands and that here too (perhaps less than in France) there are indications for ‘archipelisation’.
CD20-Negative Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A 20-Year Consecutive Case Series From a Tertiary Cancer Center
Authors: Menke Joshua R. , Spinner Michael A. , Natkunam Yasodha , Warnke Roger A. , Advani Ranjana H. , Gratzinger Dita A. 
Published: September 2020

Context.—
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare, indolent Hodgkin lymphoma subtype with distinct clinicopathologic features and treatment paradigms. The neoplastic lymphocyte-predominant cells typically express bright CD20 and other B-cell antigens, which distinguishes them from Hodgkin/Reed-Sternberg cells of lymphocyte-rich classic Hodgkin lymphoma.

Objective.—
To characterize the clinicopathologic features of CD20-negative NLPHL at a single institution.

Design.—
A retrospective search for CD20-negative NLPHL in our pathology archives and medical records was conducted.

Results.—
Of 486 NLPHL patients identified with CD20 available for review, 14 (2.8%) had LP cells with absent CD20 expression. Patients with prior rituximab administration (n = 7) and insufficient clinical history (n = 1) were excluded, leaving 6 patients with rituximab-naïve, CD20-negative NLPHL. A broad immunohistochemical panel showed the LP cells in all cases expressed B-cell antigens, particularly Oct-2, although PAX5 and CD79a were frequently also dim. CD30, CD15, and Epstein-Barr virus-encoded small RNAs were negative in all evaluated cases. Two patients had high-risk variant immunoarchitectural pattern D. One patient had extranodal disease, involving the spleen and bone, and was suspected to have large cell transformation. Standard NLPHL therapy was given, including local radiation and/or chemotherapy. Of 5 patients with available follow-up, 4 are alive in complete remission after therapy, and 1 is alive with relapsed disease.

Conclusions.—
NLPHL can lack CD20 de novo without prior rituximab therapy. In such cases, extensive immunophenotyping helps distinguish NLPHL from lymphocyte-rich classic Hodgkin lymphoma, which differ in clinical behavior and therapy. In our series, CD20-negative NLPHL showed both classic and variant histologic patterns and the expected range of clinical behavior seen in NLPHL, including 1 case with suspected large cell transformation.
The Revolution in Pediatric Drug Development and Drug Use: Therapeutic Orphans No More
Authors: Burckart Gilbert J. , Kim Clara 
Published: September 2020

This lecture was given by Dr. Burckart in association with presentation of the 2014 Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics, which is selected by the Pediatric Pharmacy Association.Multiple factors make conducting drug studies in the pediatric population difficult, resulting in a historic lack of information surrounding safe and efficacious drug dosing in children. The paradigm in pediatric drug development has shifted from normal science being that children are therapeutic orphans in the drug development system, to a model drift caused by pediatric legislation, to a model crisis caused by failed pediatric drug development trials, to finally a model revolution that includes pediatric patients routinely in drug development. Major regulatory actions and the accumulation of scientific evidence has created an environment where clinicians can expect properly labeled drug usage information for the pediatric population.
Pharmacist Prescribing in Pediatric and Neonatal Acute Care: An Observational Study
Authors: Barton Amanda , Dersch-Mills Deonne , Saunders Sydney , Mysak Tania , Zuk Dalyce 
Published: September 2020

OBJECTIVE
The intent of this project was to objectively describe the frequency of pharmacist prescribing in acute care pediatrics and neonatology and to determine the medications most often prescribed by pharmacists practicing in a jurisdiction that permits pharmacists' prescribing.

METHODS
This was a subgroup analysis of a retrospective observational study using prescribing data from an electronic medical record system used in 5 acute care hospitals (1 pediatric, 4 primarily adult but with pediatric and neonatal units) within Calgary, Alberta, Canada.

RESULTS
Considering orders for pediatric or neonatal patients only, there was a mean (SD) of 126 (226) prescriptions per pharmacist per year, with a wide range (1–1101 per year). Considering only the 9 clinical pharmacist full-time equivalents (FTEs) assigned to pediatrics and/or neonatology (i.e., not including dispensary pharmacist FTE), this represents 572 prescriptions per clinical pharmacist FTE per year (726 in pediatrics and 380 in neonatology). The most common medication classes on pediatric units included anti-infective agents, central nervous system agents, and gastrointestinal agents. In NICUs, blood formation, coagulation and thrombosis agents (mainly iron), electrolytes, caloric and water balance agents (primarily sodium supplements), and vitamins were also commonly prescribed by pharmacists.

CONCLUSIONS
As the scope of pharmacy practice expands to include prescribing, health team leadership can use these data to support incorporation of this role into practice. Prescribing pharmacists can ensure appropriate use of many medications used in acutely ill infants and children, potentially improving efficiency and quality of care.
Evaluation of Two Fosphenytoin Loading Dose Regimens and Monitoring in Infants and Neonates Less Than Six Months of Age
Authors: Bohannon Kristin K. , Leung Noelle , Cook Aaron M. , Autry Elizabeth , Gibson Julia , Naranjo Valeria , Baumann Robert , Gardner Brian 
Published: September 2020

OBJECTIVES
The objectives of the study were to compare the free serum concentrations after different fosphenytoin loading dose strategies in patients younger than 6 months old and to investigate the frequency of seizure cessation following a loading dose of fosphenytoin.

METHODS
This retrospective cohort study included neonates and infants admitted to a 150-bed children's hospital between August 1, 2014, and February 1, 2018. Patients were included if they were younger than 6 months old and had a postload free phenytoin serum concentration collected during the specified time frame. Patients were identified through a database query screening for the inclusion criteria. Patients were separated into 2 groups with the 15 mg/kg group as per protocol and the 20 mg/kg group as noted in common practice. Data collection included demographic information, fosphenytoin dose, time of administration of the fosphenytoin loading dose, time of sampling, free phenytoin serum concentration results, concomitant antiepileptic agents, albumin serum concentration, and total bilirubin serum concentration.

RESULTS
Forty-one patients were included for analysis, 12 in the 15 mg/kg group and 29 in the 20 mg/kg group. The average free phenytoin concentration after the loading dose was 2.45 ± 0.54 mg/L in the 15 mg/kg group and 2.52 ± 0.66 mg/L in the 20 mg/kg group. Seizure cessation after the fosphenytoin loading dose was achieved in 3 of 12 (25%) patients in the 15 mg/kg group and in 13 of 29 (45%) patients in the 20 mg/kg group (p = 0.305).

CONCLUSIONS
The study demonstrates that a traditional range of fosphenytoin loading dose (15–20 mg/kg) led to elevated postloading dose free phenytoin serum concentrations in the majority of patients with a seizure cessation rate of approximately 39%. The question remains as to what the optimal dose and target concentration should be in this patient population to achieve the best efficacy without risking associated toxicities.
Real World Experience of Pseudomonas aeruginosa Eradication at an Urban Pediatric Cystic Fibrosis Center
Authors: Jablonski Lindsay , Lee Carlton K.K. , Rosenstein Beryl J. , Mogayzel Peter J. , Paranjape Shruti , Pan Alice 
Published: September 2020

OBJECTIVES
Clinical practice guidelines for eradication of Pseudomonas aeruginosa (PA) in patients with cystic fibrosis (CF) have been established, but current studies have not assessed how these guidelines translate into clinical practice. This study aimed to characterize the real-world eradication strategies, eradication rates, and microbiologic outcomes of patients with first acquisition of PA at an urban pediatric CF center.

METHODS
The Cystic Fibrosis Foundation Patient Registry was used to identify patients with CF who received care between January 2014 and September 2018 and had PA isolated from an airway culture. Patients were included if they had a first positive PA culture or the first positive culture in 2 years. Data regarding patient demographics, timing and results of airway cultures, and treatment regimens were collected.

RESULTS
Over a 3.75-year period, 75 patients had an initial positive culture for PA. Of those patients, 74 (98.7%) received eradication treatment. Tobramycin inhalation solution (TIS) monotherapy was the most common regimen prescribed (52.7%) followed by TIS plus an oral fluoroquinolone (28.4%) (TIS + FQ). Of those treated, 62 (83.8%) patients had eradication of PA at first follow-up culture (median, 58 days; IQR, 49–77 days). Eradication rates (84.6% vs 76.2%, p = 0.421) and times to recurrence (6.37 months vs 5.1 months, p = 0.726) were comparable between TIS and TIS + FQ cohorts.

CONCLUSIONS
The eradication rate for PA in clinical practice is similar to that published in the literature. Consistent with published guidelines, these microbiologic outcomes do not support the addition of an oral FQ to TIS for initial PA eradication.
Remaking Berlin
Authors: Moss Timothy 
Published: September 2020

An examination of Berlin's turbulent history through the lens of its water and energy infrastructures.
In Remaking Berlin, Timothy Moss takes a novel perspective on Berlin's turbulent twentieth-century history, examining it through the lens of its water and energy infrastructures. He shows that, through a century of changing regimes, geopolitical interventions, and socioeconomic volatility, Berlin's networked urban infrastructures have acted as medium and manifestation of municipal, national, and international politics and policies. Moss traces the coevolution of Berlin and its infrastructure systems from the creation of Greater Berlin in 1920 to remunicipalization of services in 2020, encompassing democratic, fascist, and socialist regimes. Throughout, he explores the tension between obduracy and change in Berlin's infrastructures. Examining the choices made by utility managers, politicians, and government officials, Moss makes visible systems that we often take for granted.
Moss describes the reorganization of infrastructure systems to meet the needs of a new unitary city after Berlin's incorporation in 1920, and how utilities delivered on political promises; the insidious embedding of repression, racism, autarky, and militarization within the networked city under the Nazis; and the resilience of Berlin's infrastructures during wartime and political division. He examines East Berlin's socialist infrastructural ideal (and its under-resourced systems), West Berlin's insular existence (and its aspirations of system autarky), and reunified Berlin's privatization of utilities (subsequently challenged by social movements). Taking Berlin as an exemplar, Moss's account will inspire researchers to take a fresh look at urban infrastructure histories, offering new ways of conceptualizing the multiple temporalities and spatialities of the networked city.
Bridging the Seas
Authors: Ferreiro Larrie D. 
Published: September 2020

How the introduction of steam, iron, and steel required new rules and new ways of thinking for the design and building of ships.
In the 1800s, shipbuilding moved from sail and wood to steam, iron, and steel. The competitive pressure to achieve more predictable ocean transportation drove the industrialization of shipbuilding, as shipowners demanded ships that enabled tighter scheduling, improved performance, and safe delivery of cargoes. In Bridging the Seas, naval historian Larrie Ferreiro describes this transformation of shipbuilding, portraying the rise of a professionalized naval architecture as an integral part of the Industrial Age.
Picking up where his earlier book, Ships and Science, left off, Ferreiro explains that the introduction of steam, iron, and steel required new rules and new ways of thinking for designing and building ships. The characteristics of performance had to be first measured, then theorized. Ship theory led to the development of quantifiable standards that would ensure the safety and quality required by industry and governments, and this in turn led to the professionalization of naval architecture as an engineering discipline. Ferreiro describes, among other things, the technologies that allowed greater predictability in ship performance; theoretical developments in naval architecture regarding motion, speed and power, propellers, maneuvering, and structural design; the integration of theory into ship design and construction; and the emergence of a laboratory infrastructure for research.
Loss of inner kinetochore genes is associated with the transition to an unconventional point centromere in budding yeast
Authors: Vijay Nagarjun 
Published: September 2020

BackgroundThe genomic sequences of centromeres, as well as the set of proteins that recognize and interact with centromeres, are known to quickly diverge between lineages potentially contributing to post-zygotic reproductive isolation. However, the actual sequence of events and processes involved in the divergence of the kinetochore machinery is not known. The patterns of gene loss that occur during evolution concomitant with phenotypic changes have been used to understand the timing and order of molecular changes.MethodsI screened the high-quality genomes of twenty budding yeast species for the presence of well-studied kinetochore genes. Based on the conserved gene order and complete genome assemblies, I identified gene loss events. Subsequently, I searched the intergenic regions to identify any un-annotated genes or gene remnants to obtain additional evidence of gene loss.ResultsMy analysis identified the loss of four genes (NKP1, NKP2, CENPL/IML3 and CENPN/CHL4) of the inner kinetochore constitutive centromere-associated network (CCAN/also known as CTF19 complex in yeast) in both the Naumovozyma species for which genome assemblies are available. Surprisingly, this collective loss of four genes of the CCAN/CTF19 complex coincides with the emergence of unconventional centromeres inN. castelliiandN. dairenensis. My study suggests a tentative link between the emergence of unconventional point centromeres and the turnover of kinetochore genes in budding yeast.
Effects of 6-Weeks Moderate Intensity Aerobic Exercise on CD4 Count, Bone Mineral Density and Weight of People Living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital Ebonyi State
Authors: Ijego Asogwa, Eucharia , Ifeanyi Obeagu, Emmanuel , Suoton Ekine, Rupee , Okwy Asogwa, Okwudilichukwu , Amaeze Amaeze, Augustine , Ngozi Amaeze, Florence , Ochie Kalu, , Ada Orizu, Ifeoma , Chukwuebuka Abraham, John , Chukwu Odochi, Ogbu 
Published: September 2020

The main aim of this study was to find out the effects of 6 weeks moderate intensity aerobic exercises on CD4 count, bone mineral density and weight of people living with HIV/AIDS in Alex-Ekwueme Federal University Teaching Hospital, Ebonyi State. The study adopted experimental research design. The study was carried out form year 2019-February 2020. The population of the study was 40 HIV/AIDS patients that attended HIV clinics at AE-FUTHA which formed the sample size after two subjects declined from the control group in the study. Simple random sampling technique was adopted for the study. Flowcytometery (Partec Cyflow counter) Germany, Heel Densitometer (X-rite 331C), and Omron BF 400 were the instrument used for data collection of CD4 counts, BMD and weight respectively. Mean, standard deviation and ANCOVA were used to analyze the data obtained. The instruments were not validated because they are standard. The reliability coefficient obtained from the pilot study was 0.848, 0.835 and 0.994 for CD4, BMD and WEIGHT respectively. The major findings revealed that MIAE had positive effect on CD4 counts and BMD but negative effect on weight.
High Oxygen Evolution Activity of Tungsten Bronze Oxides Boosted by Anchoring of Co2+ at Nb5+ Sites Accompanied by Substantial Oxygen Vacancy
Authors: Li Xiaoning , Liu Huan , Sun Yanhua , Zhu Liuyang , Yin Xiaofeng , Sun Shujie , Fu Zhengping , Lu Yalin , Wang Xiaolin , Cheng Zhenxiang 
Published: September 2020

AbstractThe participation of lattice oxygen in the oxygen evolution reaction (OER) process has been proved to be faster in kinetics than the mechanisms where only metal is involved, although activating the lattice oxygen in the traditional rigid structures remains a big challenge. In this work, efforts are devoted to exploring a new flexible structure that is competent in providing large amounts of oxygen vacancies as well as offering the freedom to manipulate the electronic structure of metal cations. This is demonstrated by anchoring low valence state Co at high valence state Nb sites in the tetragonal tungsten bronze (TTB)‐structured Sr0.5Ba0.5Nb2‐xCoxO6‐δ, with different ratios of Co to Nb to optimize the Co substitution proportion. It is found that the occupation of Co in the Nb5+ sites gives rise to the generation of massive surface oxygen vacancies (Ovac), while Co itself is stabilized in Co2+ by adjacent Ovac. The coexistence of Ovac and LS Co2+ enables an oxygen intercalation mechanism in the optimal SBNC45 with specific activity at 1.7 V versus reversible hydrogen electrode that is 20 times higher than for the commercial IrO2. This work illuminates an entirely new avenue to rationally design OER electrocatalysts with ultrafast kinetics.
The moderating effect of strategic fit enhances business performance: Empirical evidence from the telecommunication industry
Authors: Khan Muhammad Shahid , Saengon Poramet , Cheungsirakulvit Thanaphon , Kanchanathaveekul Kanyamon 
Published: September 2020

AbstractCompetitiveness is inevitable in a highly dynamic and rapidly changing technological situation. A proper linkage among business strategies is a key to developing a sustainable competitive advantage, enhance business performance, and to cope with global competition and rapidly changing environment. Drawing on the configuration theoretic approach, this study posits that firms can improve overall performance through accurate alignment of business strategies. Strategic fit is an emerging concept to make strategy effective. This study empirically tests a conceptual model within a sample of 320 respondents from the telecommunication industry of Malaysia. Data were analyzed with statistical software SMART‐PLS, which is recently used by numerous studies. This article concludes strategic fit significantly and positively moderate the relationship of business strategies and knowledge management strategies with business performance. Results show that business strategy (innovation and competitive advantage) and knowledge management strategy (codification and personalization) have a significant and positive impact on business performance. Although this research expands our understanding of the strategic fit importance in business performance, however, worthwhile prospects of future research remain, this study is limited to monomethod and only two exogenous variables are studied, future research can use mixed‐method and other factors that can influence business performance.