bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Investment and Daily Production Limit of Largescale Fracturing Productivity Project of New Vertical Well
Authors: Sun Zhijie 
Published: November 2019

Abstract
Large-scale fracturing technology is a new type of fracturing technology developed in recent years along with the fracturing theory research of natural fractured reservoirs. The application of large-scale fracturing in vertical wells has achieved good production results. However, due to the short application time of new technology in oilfields and the low regularity of development indexes, there is no economic evaluation method for shaping. This paper evaluates the development effect of large-scale fracturing in Daqing Oilfield, clarifies the variation law of its development index, and establishes the index prediction method in the evaluation period. Through sorting out the various depreciation calculation methods used in economic evaluation, the appropriate modified production method is selected as the method of calculating depreciation. Based on the relevant data and results of economic evaluation of oilfield development, the economic evaluation method of large-scale fracturing technology productivity project has been formed, and the calculation program has been compiled. The program is used to calculate the investment boundaries of large-scale fracturing blocks with different single well daily production under the condition of multiple oil prices, draw the maps of single well investment and single well daily production boundaries under different oil prices in large-scale fracturing blocks, and analyze the sensitivity of investment boundaries. The research results will be applied in proven reserves submission, unused reserves evaluation and oilfield development planning. Using this method for reference, the boundary maps of conventional water flooding development and large-scale volume fracturing can be drawn, and the research results can be applied to a greater extent.
Influence of temperature and load on creep characteristics of soft rock similar materials
Authors: Li Jianguang , Sun Gengyu , Zou Huisong , Zhou Ziyi , Fan Xiyan 
Published: November 2019

Abstract
The soft rock specimens were prepared by using similar materials. The uniaxial creep experiments were carried out on the soft rock specimens under different temperatures and loads. The influence of temperature and load on the creep of similar soft rock and the empirical equation were obtained. The results show that the stressstrain curve is basically linear at normal temperature. As the temperature increases, the stress-strain curve continually shifts upward. As the temperature increases and the creep time increases, the average creep modulus of similar materials in soft rock decreases. As the axial pressure increases, the creep strain deformation increases continuously, and the larger the axial pressure, the more significant the creep strain changes. Through the analysis of the creep curve law, the empirical equations of three types of creep curves are given.
DNA Readout Viewer (DRV): visualization of specificity determining patterns of protein-binding DNA segments
Authors: Adam Krisztian , Gyorgypal Zoltan , Hegedus Zoltan 
Published: November 2019

Abstract

Summary
The sequence specific recognition of DNA by regulatory proteins typically occurs by establishing hydrogen bonds and non-bonded contacts between chemical sub-structures of nucleotides and amino acids forming the compatible interacting surfaces. The recognition process is also influenced by the physicochemical and conformational character of the target oligonucleotide motif. Although the role of these mechanisms in DNA-protein interactions is well-established, bioinformatical methods rarely address them directly, instead binding specificity is mostly assessed at nucleotide level. DNA Readout Viewer (DRV) aims to provide a novel DNA representation, facilitating in-depth view into these mechanisms by the concurrent visualization of functional groups and a diverse collection of DNA descriptors. By applying its intuitive representation concept for various DNA recognition related visualization tasks, DRV can contribute to unravelling the binding specificity factors of DNA-protein interactions.

Availability and implementation
DRV is freely available at https://drv.brc.hu.

Supplementary information
Supplementary data are available at Bioinformatics online.
Spatial blind source separation
Authors: Bachoc François , Genton Marc G , Nordhausen Klaus , Ruiz-Gazen Anne , Virta Joni 
Published: November 2019

SummaryRecently a blind source separation model was suggested for spatial data, along with an estimator based on the simultaneous diagonalization of two scatter matrices. The asymptotic properties of this estimator are derived here, and a new estimator based on the joint diagonalization of more than two scatter matrices is proposed. The asymptotic properties and merits of the novel estimator are verified in simulation studies. A real-data example illustrates application of the method.
Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans
Authors: Mathias Samuel R , Knowles Emma E M , Mollon Josephine , Rodrigue Amanda , Koenis Marinka M C , Alexander-Bloch Aaron F , Winkler Anderson M , Olvera Rene L , Duggirala Ravi , Göring Harald H H , Curran Joanne E , Fox Peter T , Almasy Laura , Blangero John , Glahn David C 
Published: November 2019

AbstractPrevious studies suggest that gyrification is associated with superior cognitive abilities in humans, but the strength of this relationship remains unclear. Here, in two samples of related individuals (total N = 2882), we calculated an index of local gyrification (LGI) at thousands of cortical surface points using structural brain images and an index of general cognitive ability (g) using performance on cognitive tests. Replicating previous studies, we found that phenotypic and genetic LGI–g correlations were positive and statistically significant in many cortical regions. However, all LGI–g correlations in both samples were extremely weak, regardless of whether they were significant or nonsignificant. For example, the median phenotypic LGI–g correlation was 0.05 in one sample and 0.10 in the other. These correlations were even weaker after adjusting for confounding neuroanatomical variables (intracranial volume and local cortical surface area). Furthermore, when all LGIs were considered together, at least 89% of the phenotypic variance of g remained unaccounted for. We conclude that the association between LGI and g is too weak to have profound implications for our understanding of the neurobiology of intelligence. This study highlights potential issues when focusing heavily on statistical significance rather than effect sizes in large-scale observational neuroimaging studies.
A Provably Secure Certificateless Proxy Signature Scheme Against Malicious-But-Passive KGC Attacks
Authors: Yang Wenjie , Weng Jian , Huang Xinyi , Yang Anjia 
Published: November 2019

AbstractIn certificateless proxy signature (CLPS), the key generation center is responsible for initializing the system parameters and can obtain the opportunity to adaptively set some trapdoors in them when wanting to launch some attacks. Until now, how to withstand the malicious-but-passive key generation center (MKGC) attacks in CLPS is still an interesting problem. In this paper, we focus on the challenging issue and introduce a CLPS scheme provably secure in the standard model. To the best of our knowledge, we are the first to demonstrate its security under MKGC attacks by adopting the technology of embedding the classic difficulty problems into the target entity public key rather than the system parameters during the security proof process.
Brain weight predicts yawn duration across domesticated dog breeds
Authors: Gallup Andrew C , Moscatello Lea , Massen Jorg J M 
Published: November 2019

AbstractPrevious research shows that yawning enhances intracranial circulation and regulates brain temperature. Consistent with these functional outcomes, yawn duration correlates positively with interspecies variation in brain weight across mammals, with robust relationships documented at both the taxonomic rank of class and the more restricted scale of family (e.g., Felidae). This study provides the first investigation into whether differences in brain weight within a single species, domesticated dogs Canis lupus familiaris, can predict intraspecific variation in yawn duration. Measures of yawn duration were obtained from public videos available online and then paired with previously published brain and body weight data of different dog breeds. The final sample consisted of 272 yawns from 198 dogs across 23 breeds. Consistent with recent studies, we find robust correlations between yawn duration and brain weight across breeds. Moreover, these correlations remain significant after controlling for differences in body weight across breeds. These findings replicate and extend upon past work in this area and provide further support that yawns evolved to serve an important and large-scale neurophysiologic function.
Ablation strategies for different types of atrial fibrillation in Europe: results of the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry
Authors: Schmidt Boris , Brugada Josep , Arbelo Elena , Laroche Cécile , Bayramova Sevda , Bertini Matteo , Letsas Konstantinos P , Pison Laurent , Romanov Alexander , Scherr Daniel , Tilz Roland Richard , Maggioni Aldo , Adragao Pedro , Lund Juha , Haman Ludek , Oliveira Marino Martins , Dagres Nikolaos ,   the AFA LT Investigators Group
Published: November 2019

Abstract

Aims
The ESC EORP EHRA Atrial Fibrillation (AF) Ablation Long-Term registry was designed to assess management and outcomes of AF catheter ablation procedures in Europe. To investigate the current ablation approaches and their outcomes for patients with paroxymal AF (PAF) and non-PAF in Europe.

Methods and results
Data from index ablations were collected in 27 European countries at 104 centres in a prospective fashion. Pre-procedural, procedural, and 1-year follow-up data were captured on a web-based electronic case record form. Data on the ablation procedure were available for 3446 patients. Of these, 2513 patients and 933 patients underwent pulmonary vein isolation (PVI) or PVI plus (PVIplus) additional ablation, respectively. The ablation strategy was limited to PVI in 81% and 56% of patients in the PAF and non-PAF group, respectively (P &lt; 0.001). In the non-PAF group, left atrial linear ablation and ablation of complex fragmented atrial electrograms were more commonly performed. Arrhythmias recurrence after PVI was 29% and 39% in the PAF and non-PAF group, respectively (P &lt; 0.001) and 42% after PVIplus in both groups. Atrial fibrillation related hospital admissions were more common in the PVIplus group (20% vs. 14%). A very low procedural complication rate was observed. No relevant differences were observed with regard to repeat ablation (PVI 9% and PVIplus 11%).

Conclusion
In patients with PAF and non-PAF, the ablation strategies of PVI and PVIplus led to similar arrhythmia-free survival rates after 1 year. A considerable hospital readmission rate was noted.
The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ null Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab
Authors: Jodeleit Henrika , Caesar Janina , Villarroel Aguilera Christina , Sterz Sebastian , Holdt Lesca , Beigel Florian , Stallhofer Johannes , Breiteneicher Simone , Bartnik Eckart , Siebeck Matthias , Gropp Roswitha 
Published: November 2019

Abstract

Background
To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. This is partially due to a lack of understanding of the underlying inflammatory processes. The aim of this study was to identify immunological subgroups of patients with UC and to test responsiveness to adalimumab in these subgroups in the mouse model of ulcerative colitis (UC), which is based on NOD/scid IL-2Rγ null (NSG) mice reconstituted with peripheral blood mononuclear cells (PBMCs; NSG-UC).

Methods
The immunological profiles of 40 UC patients and 16 non-UC donors were determined by flow cytometric analysis of PBMCs in a snapshot and longitudinal study and analyzed by principal component, orthogonal partial least square discrimination (oPLS-DA), and hierarchical clustering analysis. NSG mice were reconstituted 5 times at consecutive time points with PBMCs from a single donor and were analyzed for frequencies of human leukocytes and histological phenotype. The response to adalimumab of 2 identified subgroups was tested in the NSG-UC model. We used the clinical, colon, and histological score, serum levels of glutamic and aspartic acid, and IL-6 and IL-1ß. Response was analyzed by oPLS-DA.

Results
Analysis revealed a distinction between UC and non-UC donors. Hierarchical clustering identified 2 major subgroups in UC patients. Group I was characterized by TH17 and M1 monocytes, group II by TH2/TH1, and switched B cells. These subgroups reflect the dynamics of inflammation as patients. NSG-UC mice achieved an immunological phenotype reflecting the patient’s immunological phenotype. oPLS-DA revealed that NSG-UC mice reconstituted with PBMCs from group II responded better to adalimumab.

Conclusions
The combination of profiling and testing of therapeutics in the NSG-UC model may lead to individualized and phase-dependent therapies.
Incorporating environmental forcing in developing ecosystem-based fisheries management strategies
Authors: Guo Chuanbo , Fu Caihong , Olsen Norm , Xu Yi , Grüss Arnaud , Liu Huizhu , Verley Philippe , Shin Yunne-Jai 
Published: November 2019

AbstractThis study incorporated two pathways of environmental forcing (i.e. “larval mortality forcing” and “somatic growth forcing”) into an end-to-end ecosystem model (Object-oriented Simulator of Marine ecOSystEms, OSMOSE) developed for the Pacific North Coast Integrated Management Area (PNCIMA) off western Canada, in order to evaluate alternative fisheries management strategies under environmental changes. With a suite of ecosystem-level indicators, the present study first compared the ecosystem effects of different pathways of environmental forcing scenarios; and then evaluated the alternative fisheries management strategies which encompassed a series of fishing mortality rates relative to FMSY (the fishing mortality rate that produces maximum sustainable yield) and a set of precautionary harvest control rules (HCRs). The main objectives of this study were to (i) explore the ecosystem effects of different environmental forcing scenarios; (ii) identify the impacts of different fishing mortality rates on marine ecosystem structure and function; and (iii) evaluate the ecosystem-level performance of various levels of precautionary HCRs. Results indicated that different pathways of environmental forcing had different ecosystem effects and incorporating appropriate HCRs in the fisheries management process could help maintain ecosystem health and sustainable fisheries. This study provides important information on future fisheries management options within similar marine ecosystems that are facing global changes.
On a Class of Kato Manifolds
Authors: Istrati Nicolina , Otiman Alexandra , Pontecorvo Massimiliano 
Published: November 2019

Abstract
We revisit Brunella’s proof of the fact that Kato surfaces admit locally conformally Kähler metrics, and we show that it holds for a large class of higher-dimensional complex manifolds containing a global spherical shell. On the other hand, we construct manifolds containing a global spherical shell that admit no locally conformally Kähler metric. We consider a specific class of these manifolds, which can be seen as a higher-dimensional analogue of Inoue–Hirzebruch surfaces, and study several of their analytical properties. In particular, we give new examples, in any complex dimension $n \geq 3$, of compact non-exact locally conformally Kähler manifolds with algebraic dimension $n-2$, algebraic reduction bimeromorphic to $\mathbb{C}\mathbb{P}^{n-2}$, and admitting nontrivial holomorphic vector fields.
Heterogeneous Effects of Development Aid on Violent Unrest in Postwar Countries: Village-Level Evidence from Nepal
Authors: De Juan Alexander 
Published: November 2019

AbstractMany countries experience massive aid surges when civil wars end. However, operational contexts tend to remain particularly sensitive due to a combination of persisting local-level cleavages and low-quality state institutions. Consequently, aid provision risks inciting distributional conflicts and violent unrest—most notably when resources are injected into areas of high social heterogeneity or particularly weak state administration. I investigate this argument in the case of postwar Nepal. I combine geo-coded aid data with village-level information on various forms of violent unrest, as well as on social demographics and institutional quality. The panel analyses indicate positive short-term effects of aid on social unrest. More fine-grained estimations reveal that this effect is driven by a short-term escalation of violence against nonstate actors—in particular in ethnically fractionalized villages under the administration of weakly performing local-level state institutions. Descriptive cross-country analyses indicate that aid may have similar violence-inducing effects in other postwar contexts.
Antimicrobial activity of honey in periodontal disease: a systematic review
Authors: Hbibi Abdelhadi , Sikkou Khadija , Khedid Khadija , El Hamzaoui Sakina , Bouziane Amal , Benazza Driss 
Published: November 2019

AbstractBackgroundHoney has shown positive antimicrobial and anti-inflammatory actions in several dermatological studies; however, it is unclear if it could be effective in the treatment of periodontal disease.ObjectivesTo answer the question: Does honey have antimicrobial activity against periodontopathogens?MethodsSix electronic databases were screened from initiation to 31 January 2019 for randomized clinical trials (RCTs) and controlled in vitro studies exploring the antimicrobial effect of honey against periodontopathogens. Honey’s botanical origin, periopathogens that showed microbial susceptibility to honey, MICs, microbial growth conditions, control product and clinical follow-up were the main investigated outcomes. The risk of bias (RoB) of included RCTs was assessed using the Cochrane Collaboration RoB tool. The RoB of in vitro studies was evaluated based on the Sarkis-Onofre judgement model adapted to the context of honey.ResultsA total of 1448 publications were found as search results in the screened databases. Sixteen eligible papers were included based on predetermined inclusion criteria. Retained studies included 5 RCTs and 11 in vitro controlled trials. Manuka and multifloral honeys were the most studied varieties. The tested honeys showed a significant antimicrobial action, with different MICs, against eight periopathogens. Four of the five RCTs showed a high RoB, while 4 of the 11 retained in vitro studies showed a medium RoB.ConclusionsHoney showed a significant antimicrobial activity against all targeted periopathogens. Additional experiments are required to explore the entire antimicrobial spectrum of honey towards all pathogens involved in periodontal disease.
Differentiating between the effects of heat stress and lipopolysaccharide on the porcine ovarian heat shock protein response1
Authors: Seibert Jacob T , Adur Malavika K , Schultz Ronald B , Thomas Porsha Q , Kiefer Zoe E , Keating Aileen F , Baumgard Lance H , Ross Jason W 
Published: November 2019

AbstractHeat stress (HS) negatively affects both human and farm-animal health and undermines efficiency in a variety of economically important agricultural variables, including reproduction. HS impairs the intestinal barrier, allowing for translocation of the resident microflora and endotoxins, such as lipopolysaccharide (LPS), from the gastrointestinal lumen into systemic circulation. While much is known about the cellular function of heat shock proteins (HSPs) in most tissues, the in vivo ovarian HSP response to stressful stimuli remains ill-defined. The purpose of this study was to compare the effects of HS or LPS on ovarian HSP expression in pigs. We hypothesized that ovarian HSPs are responsive to both HS and LPS. Altrenogest (15 mg/d) was administered per os for estrus synchronization (14 d) prior to treatment and three animal paradigms were used: (i) gilts were exposed to cyclical HS (31 ± 1.4 °C) or thermoneutral (TN; 20 ± 0.5 °C) conditions immediately following altrenogest withdrawal for 5 d during follicular development; (ii) gilts were subjected to repeated (4×/d) saline (CON) or LPS (0.1 μg/kg BW) i.v. infusion immediately following altrenogest withdrawal for 5 d; and (iii) gilts were subjected to TN (20 ± 1 °C) or cyclical HS (31 to 35 °C) conditions 2 d post estrus (dpe) until 12 dpe during the luteal phase. While no differences were detected for transcript abundances of the assessed ovarian HSP, the protein abundance of specific HSP was influenced by stressors during the follicular and luteal phases. HS during the follicular phase tended (P &lt; 0.1) to increase ovarian protein abundance of HSP90AA1 and HSPA1A, and increased (P ≤ 0.05) HSF1, HSPD1, and HSPB1 compared with TN controls, while HS decreased HSP90AB1 (P = 0.01). Exposure to LPS increased (P &lt; 0.05) HSP90AA1 and HSPA1A and tended (P &lt; 0.1) to increase HSF1 and HSPB1 compared with CON gilts, while HSP90AB1 and HSPD1 were not affected by LPS. HS during the luteal phase increased (P &lt; 0.05) abundance of HSPB1 in corpora lutea (CL), decreased (P &lt; 0.05) CL HSP90AB1, but did not impact HSF1, HSPD1, HSP90AA1, or HSPA1A abundance. Thus, these data support that HS and LPS similarly regulate expression of specific ovarian HSP, which suggest that HS effects on the ovary are in part mediated by LPS.
Joseph Schumpeter Lecture: Sharing a Government
Authors: Ventura Jaume 
Published: November 2019

Abstract
This paper develops a simple theoretical framework to study a set of regions, each with its own regional government, who share a union or central government. These governments must decide whether to implement or discard a large number of projects that produce local benefits for the region that implements them, and externalities for the rest of the regions. Conflict or disagreement arises since different regions value projects differently. The classic assignment problem consists of deciding who decides these projects, either the union or the regional governments. It is well known that regional governments are insensitive to externalities. The key observation here is that the union government is insensitive to local benefits. Thus, each government maximizes only a piece of the value of projects, and disregards the other one. This observation leads to simple and clear rules for solving the assignment problem.