bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance imaging (MRI) versus single photon emission computed tomography (SPECT/CT) in painful total hip arthroplasty: a comparative multi-institutional analysis
Authors: Bäcker Henrik C. , Steurer-Dober Isabelle , Beck Martin , Agten Christoph A. , Decking Jens , Herzog Richard F. , Geller Jeffrey A. , Bhure Ujwal , Roos Justus E. , Strobel Klaus 
Published: October 2019

Objective:
To investigate the value of MRI in comparison to single photon emission computed tomography (SPECT)/CT in patients with painful hip arthroplasties.

Methods:
A prospective, multi-institutional study was performed. Therefore, 35 consecutive patients (21 female, 14 male, mean age 61.8 ± 13.3 years) with 37-painful hip arthroplasties were included. A hip surgeon noted the most likely diagnosis based on clinical examination and hip radiographs. Then, MRI and SPECT/CT of the painful hips were acquired. MRI and SPECT/CT were assessed for loosening, infection, fracture, tendon pathology and other abnormalities. Final diagnosis and therapy was established by the hip surgeon after integration of MRI and SPECT/CT results. The value of MRI and SPECT/CT for diagnosis was assessed with a 3-point scale (1 = unimportant, 2 = helpful, 3 = essential).

Results:
Loosening was observed in 13/37 arthroplasties (6 shaft only, 6 cup only, 1 combined). Sensitivity, specificity, positive predictive value and negative predictive value for loosening of MRI were 86%/88%/60%/100% and of SPECT/CT 93%/97%/90%/100%, respectively. MRI and SPECT/CT diagnosed infection correctly in two of three patients and fractures in two patients, which were missed by X-ray. MRI detected soft tissue abnormalities in 21 patients (6 bursitis, 14 tendon lesions, 1 pseudotumor), of which only 1 tendon abnormality was accurately detected with SPECT/CT. All 5 arthroplasties with polyethylene wear were correctly diagnosed clinically and with both imaging modalities. MRI and SPECT/CT were judged as not helpful in 0/0%, as helpful in 16%/49% and essential in 84%/51%.

Conclusion:
In patients with painful hip arthroplasty SPECT/CT is slightly superior to MR in the assessment of loosening. MRI is far superior in the detection of soft tissue, especially tendon pathologies.

Advances in knowledge:
To our knowledge this is the first prospective, multiinstitutional study which compares MRI with SPECT/CT in painful hip arthroplasties. We found that MRI is far superior in the detection of soft tissue pathologies, whereas SPECT/CT remains slightly superior regarding loosening.
The role of mitochondria-targeted antioxidant MitoQ in neurodegenerative disease
Authors: Zhang Linlin , Reyes Aurelio , Wang Xiangdong 
Published: October 2019

Abstract: The discovery of charged molecules being able to cross the mitochondrial membrane has prompted many scholars to exploit this idea to find a way of preventing or slowing down aging. In this paper, we will focus on mitochondriatargeted antioxidants, which are cationic derivatives of plastoquinone, and in particular on the mitochondria-targeted antioxidant therapy of neurodegenerative diseases. It is well known that the accumulation of amyloid-β peptide (Aβ) in mitochondria and its related mitochondrial dysfunction are critical signatures of Alzheimer’ s disease (AD). In another neurodegenerative disease, Parkinson’s disease (PD), the loss of dopaminergic neurons in the substantia nigra and the production of Lewy bodies are among their pathological features. Pathogenesis of Parkinson’s disease and Alzheimer’s disease has been frequently linked to mitochondrial dysfunction and oxidative stress. Recent studies show that MitoQ, a mitochondria-targeted antioxidant, may possess therapeutic potential for Aβ-related and oxidative stress-associated neurodegenerative diseases, especially AD. Although MitoQ has been developed to the stage of clinical trials in PD, its true clinical effect still need further verification. This review aims to discuss the role of mitochondrial pathology in neurodegenerative diseases, as well as the recent development of mitochondrial targeted antioxidants as a potential treatment for these diseases by removing excess oxygen free radicals and inhibiting lipid peroxidation in order to improve mitochondrial function.
Pharmacological treatment options for osteoarthritis: focus on symptomatic slow-acting drugs for osteoarthritis (SYSADOA) and individual patient characteristics: Resolution of the International Expert Meeting
Authors: Lila A. M. , Alekseeva L. I. , Babaeva A. R. , Gaydukova I. Z. , Gandolini G. , Zonova E. V. , Capelli R. , Karateev A. E. , Kopenkin S. S. , Martusevich N. A. , Nesmeyanova O. B. , Otteva E. N. , Rannuе F. , Raskina T. A. , Sukhareva M. L. , Taskina E. A. , Chichasova N. V. , Yakupova S. P. 
Published: October 2019

The paper presents the results of the Osteoarthritis (OA) Expert Council held on September 8, 2019, which was attended by Russian and foreign specialists. The experts considered pharmacological treatment options for OA. The expert meeting resolution states that the treatment of patients with OA should be based on an individual assessment of the patient and on a modern evidence base of therapy efficacy.Treatment of patients with OA is based on the principles of evidence-based medicine that requires an integrated approach and the need of SYSADOAs prescription. Combined drugs with therapeutic dosages of chondroitin sulfate and glucosamine in the early stages of the disease are available as basic agents. The place of paracetamol in the anesthetic therapy algorithm in OA needs to be clarified. It is also noted that when choosing nonsteroidal anti-inflammatory drugs for OA treatment, it is important to take into account individual patient characteristics and the presence of comorbidities.
Efficiency of local injections of platelet-rich plasma in shoulder impingement syndrome
Authors: Nesterenko V. A. , Karateev A. E. , Byalik E. I. , Makarov M. A. , Makarov S. A. , Byalik V. E. , Nurmukhametov M. R. , Fedotov I. A. 
Published: October 2019

Chronic shoulder pain caused by shoulder impingement syndrome (SIS) is a common pathology that leads to worse quality of life and disability. The local administration of platelet-rich plasma (PRP) is a promising treatment for SIS.Objective:to evaluate the efficiency of subacromial injection of PRP in chronic shoulder pain caused by SIS.Patients and methods.The investigation enrolled 30 patients (13 women and 17 men; mean age, 45.8±14.1 years) with chronic shoulder pain lasting ≥3 months after rotator tendons injury confirmed by ultrasound and/or magnetic resonance imaging and inefficiency of previously medical therapy. All the patients received three subacromial injections of 5 ml of PRP at a 7-day interval. The investigators assessed the course of pain during movement (100-mm visual analogue scale (VAS)) and functional ability according to the ASES and CSC questionnaires at baseline and 1, 3 and 6 months after treatment.Results and discussion.During the treatment, there was a considerable improvement in all indicators. At baseline and 1 and 3 months, the mean pain severity measured on VAS was 49.3±10.3, 32.4±21.3, and 20.6±21.3 mm, respectively; in this case, the positive effect persisted at 6-month follow-up: 10 [0; 30] mm (p<0.001). The mean ASES values were 59.5±11.5, 75.9±17.4, 82.6±17.6, and 86.7±17.1 (p<0.001) and the mean CSC scores were 72.3±14.1, 81.0±16.2, 88.5±16.1, and 92.8±16.2 (p<0.001), respectively. There were no serious adverse reactions.Conclusion.Subacromial injection of PRP is an effective and safe treatment for chronic shoulder pain associated with SIS.
Impact of the trace element status on the course of ankylosing spondylitis in the Orenburg Region patients
Authors: Yakubova U. A. , Bugrova O. V. , Krasikov S. I. , Setko N. P. , Saifutdirov R. I. 
Published: October 2019

The role of trace elements (TEs) and their imbalance in the physiology of bone tissue and in the development of inflammatory diseases of the joints and spine has been discussed in recent years; however, there is no evidence for the TE status of patients with ankylosing spondylitis (AS) and its possible impact on the course of the disease.Objective:to investigate the impact of the TE status of patients with AS on the course, clinical manifestations, and activity of the disease.Patients and methods.Examinations were made in 58 patients (39 men and 19 women), residents of the Orenburg Region, with a reliable diagnosis of AS, the duration of which was 16 [11; 26] years. The patients’ mean age was 38 [31; 48] years. HLA-B27 antigen was detected in 91.4% of cases. In addition to the generally accepted examination, atomic absorption spectrophotometry was used to determine the hair levels of 9 TEs: Cu, Zn, Fe, Mn, Cr, Co, Ni, Pb, and Cd in all the patients.Results and discussion.The AS patients living in the Orenburg Region showed TE imbalance manifested by Cu and Zn deficiency and Ni, Cr, and Mn accumulation in the hair. Multidirectional correlations were found between the values of these TEs and the presence of extra-axial (peripheral arthritis, dactylitis) and extra-skeletal (uveitis) manifestations of AS, its activity, and severity of functional disorders.Conclusion.The preliminary results may suggest that the emerging imbalance of TEs can affect the course of AS, maintaining and increasing its activity.
Profesní vidění studentů učitelství biologie zaměřené na obor a oborově didaktické jevy
Authors: Pavlasová Lenka 
Published: October 2019

Profesní vidění představuje jednu z dimenzí učitelské profesionality. Obecná shoda panuje na tom, že by mělo být rozvíjeno v průběhu přípravného vzdělávání učitelů. Volba účinných intervencí vyžaduje znalost výchozího stavu dovedností studentů. Předložená studia zjišťuje dovednosti všímání si a uvažování založeného na znalostech u budoucích učitelů biologie (n = 26) pomocí kvalitativní analýzy písemných reflexí videozáznamu vyučovací hodiny. Použitím kategoriálního systému podle Sherin a van Es (2009) bylo zjištěno, že u studentů převažují výroky zaměřené na učitele, pedagogiku a obecnou didaktiku a že k nim zaujímají převážně hodnotící a popisný přístup. Další analýzy ukázaly, že výroky uváděné ve spojení s žákem jsou ve větší míře interpretovány než výroky spojené s učitelem, kde převažuje popis a hodnocení. Podrobnější analýza oborových a oborově didaktických komentářů ukázala jejich tematickou orientaci na dvě širší oblasti: (1) metody, formy, postupy a pojetí výuky a (2) cíl výuky, očekávané výstupy, kompetence, obsah výuky. Mezi opomíjená témata patřily například pomůcky, motivace, aktivizace a pozornost žáků, instrukce učitele. Jen ojediněle studenti komentovali odborné chyby a terminologické nepřesnosti učitele. Tato zjištění poskytují důležité informace garantům kurzů didaktiky biologie.
Výuka molekulární biologie na gymnáziích: analýza současného stavu a možnosti její podpory
Authors: Janštová Vanda , Jáč Martin 
Published: October 2019

Molekulární biologie je rychle se rozvíjející vědní obor a s jejími metodami se setkáváme i v každodenním životě. Proto je důležité, aby byla zastoupena ve výuce biologie na gymnáziích. Jedním z cílů studie bylo analyzovat rozložení vzdělávacího obsahu molekulární biologie na úrovni gymnaziálních školních vzdělávacích programů (ŠVP) do jednotlivých ročníků a zjistit, která molekulárně biologická témata jsou v ŠVP zastoupena a jak často. Dalším cílem bylo otestovat srozumitelnost a atraktivitu pokročilých molekulárně biologických laboratorních cvičení určených pro žáky střední školy. ŠVP celkem 160 gymnázií ze všech krajů ČR byly hodnoceny z hlediska zařazení deseti tematických kategorií výukového obsahu molekulární biologie ve vyučovacích předmětech biologie, chemie a volitelných biologických a chemických seminářích. Data byla analyzována shlukovou analýzou a následným Ï2 testem nezávislosti. V letech 2011–2013 byly realizovány čtyři různé typy praktických cvičení z molekulární biologie, kterých se zúčastnilo 466 žáků středních škol. Cvičení probíhala buď na Přírodovědecké fakultě Univerzity Karlovy v Praze, nebo na středních školách, vedl je vysokoškolský lektor nebo středoškolský učitel. Po ukončení cvičení žáci vyplnili reflektivní dotazník, ve kterém laboratorní cvičení zhodnotili. Získaná data byla zpracována pomocí analýzy rozptylu. Výsledky ukazují, že molekulárně biologická témata jsou do výuky na gymnáziích zařazena převážně izolovaně v posledním ročníku povinné výuky biologie či chemie. Řada témat je v rámci povinné výuky opomíjena, případně je zařazena pouze v povinně volitelných seminářích. Realizovaná molekulárně biologická cvičení byla žáky celkově hodnocena velmi kladně. Byly zjištěny rozdíly hodnocení cvičení v závislosti na typu cvičení, na vyučujícím a místě průběhu laboratorního cvičení. Na základě výsledků je možné doporučit více provázat učivo molekulární biologie a ostatních biologických oborů a zařazovat pokročilá laboratorní cvičení do výuky.
Clustering and Classification based real time analysis of health monitoring and risk assessment in Wireless Body Sensor Networks
Authors: Alameen Abdalla , Gupta Ashu 
Published: October 2019

AbstractWireless body sensor networks (WBSNs) play a vital role in monitoring the health conditions of patients and are a low-cost solution for dealing with several healthcare applications. However, processing a large amount of data and making feasible decisions in emergency cases are the major challenges attributed to WBSNs. Thus, this paper addresses these challenges by designing a deep learning approach for health risk assessment by proposing fractional cat based salp swarm algorithm (FCSSA). At first, the WBSN nodes are utilized for sensing data from patient health records to acquire certain parameters for making the assessment. Based on the obtained parameters, WBSN nodes transmit the data to the target node. Here, the hybrid harmony search algorithm and particle swarm optimization (hybrid HSA-PSO) is used for determining the optimal cluster head. Then, the results produced by the hybrid HSA-PSO are given to the target node, in which the deep belief network (DBN) is used for classifying the health records for the health risk assessment. Here, the DBN is trained using the proposed FCSSA, which is developed by integrating fractional cat swarm optimization (FCSO) and salp swarm algorithm (SSA) for initiating the classification. The proposed FCSSA-based DBN shows better performance using metrics, namely accuracy, energy, and throughput with values 94.604, 0.145, and 0.058, respectively.
Supersimetrías y Parasimetrías de la Ecuación de Riccati
Authors: Reyes Marco A. , Socorro José 
Published: October 2019

Se describe cómo la ecuación de Riccati nos permite definir de manera coloquial diferentes simetrías en ecuaciones de la física matemática. En particular utilizamos la definición de supersimetría en Mecánica Cuántica, obtenida al desarrollar la segunda solución de Riccati para las ecuaciones del modelo, para introducir la parasimetría de otras ecuaciones de la física matemática y de otras áreas de las ciencias.
Efecto de la humedad y compactación de un Ultisol de la sabana del estado Monagas sobre la concentración de clorofila y carotenoides, lavado de electrolitos y contenido relativo de agua en plantas de soya
Authors: Trujillo G. María E. , Méndez N. Jesús R. , Hossne G. Américo J. , Parra D. Francisco J. 
Published: October 2019

A finales del año 2008, se realizó un ensayo a nivel de invernadero para determinar el comportamiento de la concentración de clorofila a, b, a+b y carotenoides, el lavado de electrolitos y contenido relativo de agua en el cultivo de Soya, con respecto a la humedad y compactación de un suelo Ultisol, debido a que estos dos factores son una limitante muy común en los suelos agrícolas del estado Monagas. Se trabajó bajo un diseño de bloques al azar en arreglo factorial (4 x 4) donde se estudió la interacción de cuatro niveles de compactación a través de diferentes número de golpes por capa (0, 12, 24, 36) y cuatro niveles de humedad a través de la variación de las frecuencias de riego (todos los días, cada dos días, cada tres días y cada cuatro días), luego del análisis de varianza y posterior análisis de regresión se concluyó que el factor más influyente en las variables evaluadas fue la frecuencia de riego.
Echocardiographic assessment of transposition of the great arteries and congenitally corrected transposition of the great arteries
Authors: Cohen Meryl S. , Mertens Luc L. 
Published: October 2019

Abstract
Echocardiographic assessment of patients with transposition of the great arteries and congenitally corrected transposition requires awareness of the morphology and commonly associated lesions. The pre-operative echocardiography should include a full segmental and sequential analysis. Post-operative assessment is not possible without awareness of the type of surgical procedure performed and consists of assessing surgical connections and residual lesions.
Knowledge of food habit and other daily habit are the determinants of health status: A study among the students of Chattogram regions
Authors: Al-Mamun Abdullah , Debnath Pabitra , Siddika Farida , Jahedul Islam Mohammed 
Published: October 2019

Background: Health is wealth. Success, happiness, development, and almost everything of life depend largely on good health condition. Health status of each individual varies on age, gender, food habits, physical activities, lifestyle, ethnicity and culture. To ensure a prosperous future, students’ health needs to be taken care of as they are the boatmen of any nation.
Objectives: To uphold the awareness regarding health education, daily activities, food habits and health status among the student community across Chattogram regions of Bangladesh. Methods: After ensuring ethical approval, 651 students were randomly selected from different schools, colleges and universities across Chattogram region. The data were collected, compiled, analyzed and prepared. In this study, 62% male (n=405) and 38% female (n=246) students were enrolled.
Results: Awareness of health issues was found mostly in university students while this was rare among teenagers. Body Mass Index (BMI) among teenagers was found more fluctuated and was comparatively stable after teenage. Consciousness of cigarette smoking was found appreciable, but regular physical activity awareness should be increased more. The number of frequent internet users was not appreciable.
Conclusion: Enrolled students were from different areas across Chattogram regions of Bangladesh, where some might stay with parents, some with other relatives in distant places and in academic hostels. The students were from different religious beliefs, culture, ethnicity, and from rural or coastal areas. Based on the mentioned categories of the students’ origins, their food choices, daily habits, lifestyles and health related awareness could be different.
Bactericidal, protistocidal, nematodicidal properties and chemical composition of ethanol extract of Punica granatum peel
Authors: Palchykov V. A. , Zazharskyi V. V. , Brygadyrenko V. V. , Davydenko P. O. , Kulishenko O. M. , Borovik I. V. , Chumak V. , Kryvaya A. , Boyko O. O. 
Published: October 2019

We have studied the chemical composition and antibacterial profile of ethanolic extract of Punica granatum L. (Lythraceae) on strains of microorganisms in vitro. Analysis using GC-MS showed 5-hydroxymethylfurfural (36.6%), D-sucrose (23.2%), sorbitol (6.7%), palmitic acid β-monoglyceride (5.6%), 2-furancarboxaldehyde (3.5%) and β-D-glucopyranose (3.3%) as the major components of the title extract. The experiment revealed a positive antibacterial effect of extracts obtained from P. granatum on 14 strains specifically Enterobacteriaceae microorganisms (Escherichia coli, Enterobacter aegorenеs, Proteus vulgaris, Serratia marcescens, Klebsiella pneumonia), Listeriaceae (Listeria ivanovi, L. іnnocua, L. monocytogenes) and yeasts from the family Saccharomycetaceae (Candida albicans). Our study showed that in many cases these extracts more intensively affect multi-resistant strains of microorganisms than macrolide antibiotic azithromycin and is therefore a source of molecules to be exploited in medicine or by the pharmaceutical industry. The investigated extracts of P. granatum can be recommended for further in-depth research against poly-resistant strains of the above-mentioned microorganisms. Effective drugs perform a leading role in providing stable veterinary well-being of livestock and healthcare of the population. The present study showed that the studied plant species more intensively affects multi-resistant strains of microorganisms than sodium salt of azithromycin. Lethal concentration (LC50) of ethanol extract from pomegranate for Paramecium caudatum Ehr. equaled 0.3%. Death of 100% of nematode larvae of Strongyloides papillosus (Ihle) was recorded during 24 h exposition in 20% extract of P. granatum peel.
Sorafenib for Patients with Hepatocellular Carcinoma and Child-Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study
Authors: Labeur Tim A. , Achterbergh Roos , Takkenberg Bart , Van Delden Otto , Mathôt Ron , Klümpen Heinz-Josef 
Published: October 2019

Abstract

Lessons Learned
Recruitment of patients with advanced hepatocellular carcinoma and Child-Pugh B for sorafenib treatment and additional pharmacokinetic studies is challenging. Patients with Child-Pugh B liver cirrhosis have high rates of cirrhosis-related adverse events.

Background
Few data are available on the pharmacokinetics (PK) of sorafenib in patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh B liver cirrhosis. This study aimed to explore the sorafenib PK and its relationship with efficacy and toxicity in these patients.

Methods
Patients with advanced HCC and Child-Pugh B7-8 liver function were prospectively recruited at a tertiary center. Adverse events (AEs), progression-free survival (PFS), and overall survival (OS) were recorded. Patients received a starting dose of 200 b.i.d. with toxicity-adjusted dose escalation to a target dose of 400 mg b.i.d. with PK sampling at fixed time points.

Results
Between May 2014 and March 2017, 12 patients were screened, of whom 7 progressed to a terminal stage during the screening (n = 6) or shortly after recruitment (n = 1). The five included patients had median PFS of 3.8 months (range, 1.7–10.8) and OS of 7.4 months (range, 1.7–25.8). Three patients had severe AEs and one patient had a partial response with an OS of 25.8 months. In 2017, the trial was aborted for lack of accrual.

Conclusion
Because of low accrual, no conclusion can be drawn on the sorafenib PK in patients with advanced HCC and Child-Pugh B liver cirrhosis. The poor survival and frequent cirrhosis-related AEs suggest limited benefit for most of these patients.
The Canadian National Seismograph Network: Upgrade and Status
Authors: Bent Allison L. , Côté Timothy J. , Seywerd Henry C. J. , McCormack David A. , Coyle Kathryn A. 
Published: October 2019

Abstract
The Canadian National Seismograph Network (CNSN) operated by Natural Resources Canada consists of approximately 200 stations. Data from this network are used to produce the national earthquake catalog, to provide alerts in the aftermath of an earthquake, to develop the national seismic hazard maps, and for research within Canada and internationally. A significant upgrade to the instrumentation and infrastructure of the CNSN, which began in 2014, is nearing completion. The newly refurbished network is uniform in terms of instrumentation with the remaining single-component short-period stations converted to three-component broadband stations and consistent sampling rates across the network. Strong-motion instruments are now collocated with weak-motion instruments at many sites in all regions of Canada, and there is also a significant increase in the number of stand-alone strong-motion sites. Improvements in telecommunications were aimed at improving reliability and decreasing latency. All upgraded stations undergo a series of quality checks before the data are approved for dissemination. Data from the CNSN are freely available to the seismological community and the general public.