bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’antiquarium voûté dit « grotte » du château La Fontaine de Pierre-Ernest de Mansfeld à Luxembourg-Clausen, xvie siècle
Authors: Mousset Jean-Luc , Paulke Matthias 
Published: December 2020

Le château que le gouverneur du duché de Luxembourg, le comte Pierre-Ernest de Mansfeld (1517-1604), s’est fait construire à Clausen, au pied de la ville de Luxembourg, a renfermé, à côté d’un antiquarium qualifié de cryptoportique et servant de couloir, encore deux autres qui ont été nommés dans les textes « grotte » ou « antre ». L’une des grottes était à ciel ouvert et l’autre voûtée. Mais aucune d’elles ne possédait un décor rustique, c’est-à-dire un des aspects formels qui caractérise une grotte artificielle. La présente contribution est plus précisément consacrée à l’antiquarium dit grotte voûtée de Clausen. Peu connu car découvert récemment en 2003 au cours de fouilles, il est daté vers 1575-1580. Il constitue l’élément central d’un dispositif architectural plus vaste fortement marqué par la Rome antique et tout à fait exceptionnel dans les anciens Pays-Bas.
Processos de Trabalho e a Saúde Mental dos Trabalhadores nos CAPS: uma revisão integrativa
Authors: Merçom Luciana Nascimento , Constantinidis Teresinha Cid 
Published: December 2020

O trabalhador de saúde mental se encontra no centro da Reforma Psiquiátrica Brasileira, movimento que trouxe ampliação do questionamento das práticas e formas de relação estabelecidas com a loucura. Diante do contato deste profissional com o sofrimento e sua centralidade nas ações em saúde mental, este artigo objetivou verificar como a produção científica nacional tem discutido as principais questões que atravessam o processo de trabalho dos profissionais de saúde mental atuantes nos CAPS e os reflexos disto em sua saúde mental. Foi efetuada uma revisão integrativa de literatura nas bases de dados on-line Biblioteca Virtual em Saúde (BVS) e Pubmed de artigos publicados entre 2002 e 2019, resultando em uma amostra de 25 artigos. A revisão mostrou que os trabalhadores de saúde mental estão envoltos em um contexto desafiador, diante da tarefa de produzir atenção e cuidado em saúde mental segundo os preceitos da Reforma Psiquiátrica. Conclui-se que os impasses colocados na lida com a loucura, na falta de recursos e capacitação para lidar com determinadas situações, nas relações entre os profissionais, constituem situações que ocasionam sofrimento, desprazer e fontes de estresse. No entanto, o trabalho em saúde mental, para estes profissionais, constitui-se também como fonte de prazer e realização.
Serum level of the neuropeptide substance ‘P’ in patients with acne vulgaris
Authors: Nagiub Heba , Elbayomi Yousef , Mansour Mostafa , Zohdy Marwa 
Published: December 2020

Background
Acne vulgaris is a very common chronic inflammatory disease of pilosebaceous units affecting up to 80% of adolescents with complex pathogenesis. Substance P (SP) is a neuropeptide that is secreted from the terminal ends of special sensory nerves, acts as a neurotransmitter, and is involved in inflammatory processes and pain. Various studies have proved that the inflammatory process within the pilosebaceous unit is modulated by neuropeptides, especially SP.

Objective
The aim of this study was to evaluate the correlation between SP level and severity of acne.

Patients and methods
SP levels were estimated in 45 patients with acne vulgaris (AV) and 35 age-matched and sex-matched controls, with exclusion of patients who were taking anxiolytics, antipsychotics, or related drugs within the last year, present or past medical history of isotretinoin or hormonal therapy within the last 3 months, patients on systemic antibiotic for at least 3 months before the study, and patients with any neurological or psychiatric diseases such as mood disorders, major depressive disorder, and anxiety disorders. SP level was detected quantitatively by enzyme-linked immunosorbent assay method.

Results
SP level was significantly higher in the acne group vs the control group (P<0.001). SP level was highest in the severe acne group, followed by the moderate group and lastly the mild group. SP level was higher in the smoker group vs the nonsmoker group, with a statistically significant difference (P<0.05).

Conclusion
There was a statistically significant relation between acne severity and the serum levels of SP.
IMPACT OF LEADERSHIP STYLES ON PSYCHOLOGICAL DISTRESS AND JOB SATISFACTION AMONG EMPLOYEES IN SABAH
Authors: TAMBY OMAR AISHAH , UNGKU AHMAD UNGKU NORULKAMAR 
Published: December 2020

This research was aimed at determining the effects of toxic leadership on psychological distress and job satisfaction. Data were collected from among 200 employees who are working in the public sector in Kota Kinabalu, Sabah. The empirical results through Pearson Correlation found employeesâ€™ psychological distress indicating a positive relationship with toxic leadership. Meanwhile it was found that there is negative relationship between toxic leadership and job satisfaction. This study provides a strong evidence that could help the top management and individuals in the public sector to find strategies to prevent a growth of toxic leadership.
Keywords: Toxic leadership, psychological distress, job satisfaction, public sector, leadership.
PEMANFAATAN GOOGLE CLASSROOM SEBAGAI MEDIA PEMBELAJARAN INTERAKTIF DI TENGAH DAMPAK PENYAKIT VIRUS CORONA 19 BAGI PENGAJAR
Authors: Fauzan Fauzan Asrin 
Published: December 2020

ABSTRAK
Pandemi Wabah Virus Corona 19 (COVID 19) menjadi permasalahan kesehatan dunia pada saat ini. Hampir seluruh dunia merasakan dampak wabah penyakit mematikan ini, baik disektor ekonomi, pemerintahan, pendidikan dan lain sebagainya. Negara Republik Indonesia telah berupaya untuk mengajak seluruh institusi bidang pendidikan belajar di rumah. Karena merupakan kebijakan pemerintah yang tepat pada saat ini. Mulai dari sekolah dasar sampai dengan perguruan tinggi, agar selalu aktif memberikan layanan pendidikan secara daring bagi anak bangsa di tengah wabah virus corona yang melanda Republik Indonesia. Tujuannya adalah memutus mata rantai penyebaran secara masif virus corona di area pendidikan. Salah satu solusi belajar dirumah secara daring adalah menggunakan google classroom sebagai media pembelajaran interaktif berbasis e-learning yang memudahkan pengajar dan peserta didik melakukan proses belajar mengajar di rumah untuk menunjang pembelajaran berbasis teknologi informasi dan komunikasi. Pemanfaatan google classroom saat ini sangat efektif dan efisien yang tidak terbatas oleh ruang dan waktu. Pengajar dapat memberikan bahan ajar secara online, baik berupa teks, gambar, audio, maupun video kepada peserta didik. Manfaat yang didapat peserta didik adalah peserta didik dapat mengulang materi yang telah dibagikan oleh pengajar secara terus menerus.

Kata kunci: Virus Corona 19, Google Classroom, E-Learning, Pengajar
LA CAPA DE PAPEL: como roubar a atenção do observador em manuais instrucionais para educação em saúde | “LA CAPA DE PAPEL”: how to raise the reader's attention in instructional manuals for health education
Authors: Medina Camila , Domiciano Cassia Leticia Carrara , Landim Paula Da Cruz , Medola Fausto Orsi 
Published: December 2020

“La capa de papel” conta a história das capas de alguns materiais gráficos instrucionais de saúde, que embora sejam importantes artefatos comunicacionais, apresentam problemas de legibilidade, usabilidade, layout e conteúdo. Foram coletadas 17 capas de manuais disponibilizadas por fabricantes de próteses auditivas (7 digitais,10 impressas), analisadas de acordo com o tamanho, tipo de suporte, personalização, dispositivos por manual, foco e tipo de imagem. Resultados demonstraram que nenhuma capa exibiu elementos que remetam personalização e os tamanhos finais são menores que o recomendado. Nos impressos, problemas no tipo de papel foram diagnosticados (n=4). Treze manuais contemplaram mais que um dispositivo. A maioria (n=12) exibiu imagens figurativas, das quais 10 focaram nos dispositivos. Sugere-se aumentar o tamanho dos materiais, incluir elementos para personalização e apresentar um manual por modelo. Portanto, cabe ao designer aprimorar estes materiais sob o ponto de vista gráfico-informacional para promover empatia, interação e atrair o leitor.*** “La capa de papel” tells the story of the covers of some medical device manuals that are important communication means but present reading, usability, layout and content problems. Seventeen covers of hearing aid manuals made by manufacturers (7 digital, 10 printed) were collected and analyzed according to size, support type, personalization, number of devices per manual, focus and image type. Results showed that none of the covers exhibited personalization-related elements and final sizes are smaller than recommended. For printed manuals, paper type problems were detected (n = 4). Thirteen manuals contemplated more than one device. The majority (n = 12) exhibited figurative images, of which 10 focused on the devices. Authors suggest increasing the size of the materials, including personalization elements and providing one manual per model. It’s up to the designer the improvement of these materials from a graphic and informational point of view, in order to promote empathy, interaction and getting the reader’s attention.
Sykepleiestudentenes kliniske praksis – om klinisk læringsmiljø og studenttilfredshet
Authors: Andreasen Eva Mari , Høigaard Rune , Haraldstad Kristin 
Published: December 2020

Nurse practice – clinical learning environment and student satisfaction
The purpose of this study was to investigate nursing students’ satisfaction with the clinical learning environment during clinical practice. A questionnaire was distributed to nursing students at a university (N=250) in Norway. Student satisfaction, task orientation, pedagogical atmosphere, supervisory relationship, and the premises of nursing on the ward were measured. Of the 250 students invited, 163 (66 %) completed the survey. Nursing students were largely satisfied with their clinical placement experiences, but they were more satisfied with hospital placements than home care placements. Supervision more than once a week and having one supervisor was important for student satisfaction. Students’ relationship with their supervisors was strongest associated with satisfaction with their clinical placements. Supervisors play an important role in nursing students’ satisfaction with their clinical practice, with results indicating that this should be emphasized in the development of nursing education. The results indicate that nursing guidance skills should be strengthened to ensure the quality of clinical placements in nursing education.
Evaluation of the synergistic effect of acetylation and poly(acrylic acid‐co‐2‐hydroxyethyl acrylate) branches on irradiated‐cornstarch for polyester warp sizing
Authors: Zha Xiaochuan , Sadi Md Shak , Yang Yuxuan , Liu Xingqiao , Huang Nianhua 
Published: December 2020

AbstractStarch‐based materials have received great attention for textile warp sizing due to their high modification potentiality, low cost, and biodegradability. However, the brittleness of starch film and low compatibility with polyester has made it challenging to withstand the friction of modern high‐speed weaving machinery. To overcome such drawbacks, a series of irradiated‐cornstarch acetate‐g‐poly (acrylic acid‐co‐2‐hydroxyethyl acrylate) samples with different grafting ratios were designed and prepared in this study. Fourier transform infrared, X‐ray diffraction, and scanning electron microscopy were employed to characterize the structural properties. The prepared starches were cooked for sizing on the roving and spun yarn, for the film formation. The adhesion was evaluated by measuring the bonding force of starch to roving fibers, the abrasion resistance of sized polyester yarn, and water dispersion. Whereas the film properties were investigated in terms of tensile strength, elongation, hydrophilicity, and moisture regain from the air. Results revealed that esterification‐grafting can significantly improve adhesion and film mechanical properties. The enhancement of abrasion resistance reached to 262%. With the increase of grafting ratio, hydratability, water dispersion, and elongation of the film increased, twice as high as that of irradiated‐cornstarch (IS). Desizability was above 88%, reaching the industry standard. The improvement in the warp sizing performance demonstrated that combining acetylation with hydrophilic branches is an effective strategy for the development of high‐performance starch sizing materials.
Establishment and validation of a prognostic nomogram based on a novel five‐DNA methylation signature for survival in endometrial cancer patients
Authors: Li Xingchen , Yin Fufen , Fan Yuan , Cheng Yuan , Dong Yangyang , Zhou Jingyi , Wang Zhiqi , Li Xiaoping , Wang Jianliu 
Published: December 2020

AbstractBackgroundThis study aimed to explore the prognostic role of DNA methylation pattern in endometrial cancer (EC) patients.MethodsDifferentially methylated genes (DMGs) of EC patients with distinct survival from The Cancer Genome Atlas (TCGA) database were analyzed to identify methylated genes as biomarkers for EC prognosis. The Least Absolute Shrinkage and Selection Operator (LASSO) analysis was used to construct a risk score model. A nomogram was built based on analysis combining the risk score model with clinicopathological signatures together, and then verified in the validation cohort and patients in our own center.ResultsIn total, 157 DMGs were identified between different prognostic groups. Based on the LASSO analysis, five genes (GBP4, OR8K3, GABRA2, RIPPLY2, and TRBV5‐7) were screened for the establishment of risk score model. The model outperformed in prognostic accuracy at varying follow‐up times (AUC for 3 years: 0.824, 5 years: 0.926, and 7 years: 0.853). Multivariate analysis identified four independent risk factors including menopausal status (HR = 3.006, 95%CI: 1.062–8.511, p = 0.038), recurrence (HR = 2.116, 95%CI: 1.061–4.379, p = 0.046), lymph node metastasis (LNM, HR = 3.465, 95%CI: 1.225–9.807, p = 0.019), and five‐DNA methylation risk model (HR = 3.654, 95%CI: 1.458–9.161, p = 0.006) in training cohort. The performance of the nomogram was good in the training (AUC = 0.828), validation (AUC = 0.866) and the whole cohorts (AUC = 0.843). Furthermore, we verified the nomogram with 24 patients in our center and the Kaplan–Meier survival curve also proved to be significantly different (p < 0.01). The subgroup analysis in different stratifications indicated that the accuracy was high in different subgroups for age, histological type, tumor grade, and clinical stage (all p < 0.01).ConclusionsBriefly, our work established and verified a five‐DNA methylation risk model, and a nomogram merging the model with clinicopathological characteristics to facilitate individual prediction of EC patients for clinicians.
Rührtechnologische Forschung zum Suspendieren und Dispergieren
Authors: Wollny Stefan , Sperling Reinhard 
Published: December 2020

AbstractIm Beitrag geht es um den Einfluss der Rührer auf das Suspendierverhalten schwerer Partikel und den Einzug leichter Partikel von der Fluidoberfläche. Es wird gezeigt, dass für den Einzug leichter Partikel eine Ein‐Stromstörer‐Variante und ein nach oben fördernder Axialrührer optimal sind. Es wird auch die Problematik des beanspruchungsarmen Rührens vorgestellt und wie folgt zusammengefasst: Jene Rührer/Reaktor‐Konfiguration, die für einen bestimmten spezifischen Leistungseintrag die höchste Rührerumfangsgeschwindigkeit benötigt, produziert die höchste hydrodynamische Partikelbeanspruchung.
Coumarin‐Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action
Authors: Thacker Pavitra S. , Srikanth Danaboina , Angeli Andrea , Singh Priti , Chinchilli Krishna Kartheek , Arifuddin Mohammed , Supuran Claudiu T. 
Published: December 2020

AbstractA series of coumarin‐thiourea hybrids (4 a–o) has been synthesized, and the compounds have been evaluated against the tumour associated transmembrane isoform, human (h) carbonic anhydrase (CA) hCA IX and the less‐explored cytosolic isoform, hCA XIII. All compounds exhibited potent inhibition of both isoforms, with KI values of <100 nM against hCA IX. Compound 4 b was the best inhibitor (KI=78.5 nM). All the compounds inhibited hCA XIII in the low‐nanomolar to sub‐micromolar range, with compound 4 b again showing the best inhibition (KI=76.3 nM). With compound 4 b as a lead, more‐selective inhibitors of hCA IX and hCA XIII or dual hCA IX/XIII inhibitors might be developed.
Neuroplasticity in N‐methyl‐d‐aspartic acid receptor signaling in subregions of the rat rostral ventrolateral medulla following sedentary versus physically active conditions
Authors: Fyk‐Kolodziej Bozena E. , Ghoddoussi Farhad , Mueller Patrick J. 
Published: December 2020

AbstractThe rostral ventrolateral medulla (RVLM) is a brain region involved in normal regulation of the cardiovascular system and heightened sympathoexcitatory states of cardiovascular disease (CVD). Among major risk factors for CVD, sedentary lifestyles contribute to higher mortality than other modifiable risk factors. Previous studies suggest excessive glutamatergic excitation of presympathetic neurons in the RVLM occurs in sedentary animals. Therefore, the purpose of this study was to examine neuroplasticity in the glutamatergic system in the RVLM of sedentary and physically active rats. We hypothesized that relative to active rats, sedentary rats would exhibit higher expression of glutamate N‐methyl‐d‐aspartic acid receptor subunits (GluN), phosphoGluN1, and the excitatory scaffold protein postsynaptic density 95 (PSD95), while achieving higher glutamate levels. Male Sprague–Dawley rats (4 weeks old) were divided into sedentary and active (running wheel) conditions for 10–12 weeks. We used retrograde tracing/triple‐labeling techniques, western blotting, and magnetic resonance spectroscopy. We report in sedentary versus physically active rats: 1) fewer bulbospinal non‐C1 neurons positive for GluN1, 2) significantly higher expression of GluN1 and GluN2B but lower levels of phosphoGluN1 (pSer896) and PSD95, and 3) higher levels of glutamate in the RVLM. Higher GluN expression is consistent with enhanced sympathoexcitation in sedentary animals; however, a more complex neuroplasticity occurs within subregions of the ventrolateral medulla. Our results in rodents may also indicate that alterations in glutamatergic excitation of the RVLM contribute to the increased incidence of CVD in humans who lead sedentary lifestyles. Thus, there is a strong need to further pursue mechanisms of inactivity‐related neuroplasticity in the RVLM.
The Bonding Interactions in Fluorinated Vinylogous Amides: A CF3‐Substituted Carbonyl‐β‐Aminoenone as a Case Study
Authors: Espitia Cogollo Edeimis , Jios Eliana , Hidalgo Alejandra , Ulic Sonia Elizabeth , Echeverría Gustavo Alberto , Piro Oscar Enrique , Jios Jorge Luis 
Published: December 2020

AbstractA new perfluoromethylated vinylogous amide, (Z)‐4,4,4‐trifluoro‐1‐(2‐hydroxyphenyl)‐3‐(2‐methoxyethylamino)‐2‐buten‐1‐one, is chosen as an example to investigate the bonding interactions in solid state. The Z, s‐cis form is the dominant conformation in both solution and solid state. Intramolecular hydrogen bonding determines this conformational preference in a nonpolar solvent (NMR spectra). Carbonyl and phenol groups are sensitive to the intra‐ and intermolecular contacts (vibrational spectra). The supramolecular assembly (X‐ray diffraction) is governed by NH⋯O and OH⋯O strong intermolecular hydrogen bonds giving rise to center‐symmetric and graph‐set motifs. The π‐stacking, F⋯H and F⋯F interactions are also discussed (Hirshfeld analysis).
Conceptual design of a health suit to prevent COVID‐19 and similar type other airborne virus infections
Authors: Sinha Srikrishna , Sinha Srikanta , Sinha Sanjula , Manna Bibekananda 
Published: December 2020

AbstractWe present the conceptual design of a complete health suit. This suit is designed to provide clean, virus‐free air to its wearer either from an oxygen cylinder or through an air purification system that consists of an ultraviolet lamp, or a soap solution‐based air purifier. This health suit, if designed and fabricated properly, should help prevent the spread of COVID‐19 and similar type other airborne virus infections in human beings.
Intracranial pressure monitoring following traumatic brain injury: evaluation of indications, complications, and significance of follow-up imaging—an exploratory, retrospective study of consecutive patients at a level I trauma center
Authors: Bumberger Alexander , Braunsteiner Tomas , Leitgeb Johannes , Haider Thomas 
Published: December 2020

Abstract
Background
Measurement of intracranial pressure (ICP) is an essential part of clinical management of severe traumatic brain injury (TBI). However, clinical utility and impact on clinical outcome of ICP monitoring remain controversial. Follow-up imaging using cranial computed tomography (CCT) is commonly performed in these patients. This retrospective cohort study reports on complication rates of ICP measurement in severe TBI patients, as well as on findings and clinical consequences of follow-up CCT.

Methods
We performed a retrospective clinical chart review of severe TBI patients with invasive ICP measurement treated at an urban level I trauma center between January 2007 and September 2017.

Results
Clinical records of 213 patients were analyzed. The mean Glasgow Coma Scale (GCS) on admission was 6 with an intra-hospital mortality of 20.7%. Overall, complications in 12 patients (5.6%) related to the invasive ICP-measurement were recorded of which 5 necessitated surgical intervention. Follow-up CCT scans were performed in 192 patients (89.7%). Indications for follow-up CCTs included routine imaging without clinical deterioration (n = 137, 64.3%), and increased ICP values and/or clinical deterioration (n = 55, 25.8%). Follow-up imaging based on clinical deterioration and increased ICP values were associated with significantly increased likelihoods of worsening of CCT findings compared to routinely performed CCT scans with an odds ratio of 5.524 (95% CI 1.625–18.773) and 6.977 (95% CI 3.262–14.926), respectively. Readings of follow-up CCT imaging resulted in subsequent surgical intervention in six patients (3.1%).

Conclusions
Invasive ICP-monitoring in severe TBI patients was safe in our study population with an acceptable complication rate. We found a high number of follow-up CCT. Our results indicate that CCT imaging in patients with invasive ICP monitoring should only be considered in patients with elevated ICP values and/or clinical deterioration.