bluuebunny/crossref_metadata_2025_split huggingface dataset:
A precessing and nutating jet in OJ287
Authors: Britzen Silke , Fendt C. , Witzel G. , Qian S.-J. , Pashchenko I. N. , Kurtanidze O. , Zajacek M. , Martinez G. , Karas V. , Aller M. , Aller H. , Eckart A. , Nilsson K. , Arévalo P. , Cuadra J. , Subroweit M. , Witzel A. 
Published: April 2020

AbstractWe re-analyzed OJ287 in 120 Very Long Baseline Array (VLBA, MOJAVE) observations (at 15 GHz) covering the time span between Apr. 1995 and Apr. 2017. We find that the radio jet motion over the sky is consistent with a precessing and nutating jet source. The variability of the radio flux-density can be explained by Doppler beaming due to a change in the viewing angle. We suggest that part of the optical emission is due to synchrotron emission related to the jet radiation. We find a strikingly similar scaling for the timescales for precession and nutation as indicated for SS433 with a factor of roughly 50 times longer in OJ287.
Etablierung und Evaluation einer multinationalen Wissenschaftsakademie: Ein neues Modell zur Stärkung des wissenschaftlichen Nachwuchses in der mikrochirurgischen Forschung – Ein Konsensus Papier der DAM
Authors: Horch R. E. , Kengelbach-Weigand A. , Pierer G. , Kneser U. , Schaefer D. , Boos A. M. , Arkudas A. , Schmidt V. J. 
Published: April 2020

Zusammenfassung
Hintergrund Die Bildung von beruflichen Netzwerken und Kooperationen ist neben einer guten Weiterbildung für eine erfolgreiche Karriere meist grundlegend. In etlichen Fachdisziplinen existieren hierfür bereits kleinere Symposien oder Konferenzen. Im Forschungszweig der Mikrochirurgie gab es bislang jedoch noch keine dezidierte Möglichkeit für Nachwuchswissenschaftler sich untereinander zu vernetzen.
Methoden Im Jahre 2017 wurde erstmalig eine Wissenschaftsakademie durch die Deutschsprachige Arbeitsgemeinschaft für Nerven und Gefäße (DAM) initiiert. Das Ziel war es, mikrochirurgisch forschende junge Ärzte sowie Wissenschaftler im kleinen Rahmen einmal jährlich zusammenzubringen und zu vernetzen, um Synergien für gemeinsame Forschungsprojekte zu entwickeln. Hierfür wurden jeweils von den Vorständen der Forschungseinrichtungen, die in der DAM organisiert sind, motivierte Nachwuchswissenschaftler zur Akademie entsendet. Nach einem Kennenlernen in lockerer Atmosphäre, bekamen die Teilnehmer die Möglichkeit, sich im Rahmen von Themenblöcken und unter Moderation durch erfahrene Mentoren ihr jeweiliges Forschungsprojekt vorzustellen. Es schloss sich eine Diskussionsrunde sowie Kleingruppenarbeit an, in der Kenntnisse und Methoden ausgetauscht sowie Anknüpfungspunkte für mögliche spätere Kooperationen identifiziert wurden.
Ergebnisse Die DAM Wissenschaftsakademie erwies sich in den vergangenen 3 Jahren als ein optimales Format, um Netzwerke von jungen mikrochirurgisch interessierten Ärzten und Wissenschaftlern zu initiieren und zu fördern. Es ergaben sich zahlreiche lebhafte und vertiefte Diskussionen, die vor allem durch die offene Arbeitsatmosphäre und die Verpflichtung zur Vertraulichkeit zustande kamen. Die meisten Synergien zeigten sich u. a. auf dem Gebiet Angiogenese, Bioreaktor, Karzinom-ADSC Interaktionen, Stammzellen, AV loop Modell, Ischämie/Reperfusion und Nervenregeneration. Die Teilnehmer gaben in abschließender Evaluation durchweg ein sehr positives Feedback mit dem Wunsch der Fortsetzung dieser Akademie.
Schlussfolgerung Die DAM Wissenschaftsakademie kann als eine sinnvolle Ergänzung zu den bereits bestehenden Möglichkeiten der Vernetzung unter mikrochirurgischen Forschern betrachtet werden. Die bisherigen Erfahrungen lassen annehmen, dass sich hieraus langfristige Kooperationen und ein dauerhafter Wissenstransfer unter den Teilnehmern ergeben.
A study of possible-worlds semantics of relevance-sensitive belief revision
Authors: Aravanis Theofanis , Peppas Pavlos , Williams Mary-Anne 
Published: April 2020

Abstract
Parikh’s relevance-sensitive axiom (P) for belief revision is open to two different interpretations, i.e. the weak and the strong version of (P), both of which are plausible depending on the context. Given that strong (P) has not received the attention it deserves, in this article, an extended examination of it is conducted. In particular, we point out interesting properties of the semantic characterization of the strong version of (P), as well as a vital feature of it that, potentially, results in a significant drop on the resources required for an implementation of a belief-revision system. Lastly, we shed light on the natural connection between global and local revision functions, via their corresponding semantic characterization, hence, a means for constructing global revision functions from local ones, and vice versa, is provided.
Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense
Authors: Xia Xuhua 
Published: April 2020

Abstract
Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus (including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues provide different cellular environments, especially different antiviral and RNA modification activities that can alter RNA modification signatures observed in the viral RNA genome. The zinc finger antiviral protein (ZAP) binds specifically to CpG dinucleotides and recruits other proteins to degrade a variety of viral RNA genomes. Many mammalian RNA viruses have evolved CpG deficiency. Increasing CpG dinucleotides in these low-CpG viral genomes in the presence of ZAP consistently leads to decreased viral replication and virulence. Because ZAP exhibits tissue-specific expression, viruses infecting different tissues are expected to have different CpG signatures, suggesting a means to identify viral tissue-switching events. The author shows that SARS-CoV-2 has the most extreme CpG deficiency in all known betacoronavirus genomes. This suggests that SARS-CoV-2 may have evolved in a new host (or new host tissue) with high ZAP expression. A survey of CpG deficiency in viral genomes identified a virulent canine coronavirus (alphacoronavirus) as possessing the most extreme CpG deficiency, comparable with that observed in SARS-CoV-2. This suggests that the canine tissue infected by the canine coronavirus may provide a cellular environment strongly selecting against CpG. Thus, viral surveys focused on decreasing CpG in viral RNA genomes may provide important clues about the selective environments and viral defenses in the original hosts.
Social media resources and export performance: the role of trust and commitment
Authors: Mahmoud Mahmoud Abdulai , Adams Matilda , Abubakari Aidatu , Commey Nicholas Oblitei , Kastner Adelaide Naa Amerley 
Published: April 2020

PurposeThe study sought to examine the influence of social media resources on export performance and the role commitment and trust play in this relationship using an integrated model.Design/methodology/approachA quantitative survey design was employed for this study. Empirical data for this paper were drawn from 210 exporting firms in Ghana, using purposive sampling technique. The hypothesized links were analyzed using structural equation modeling.FindingsThe result of this study reveals that social media resources and marketing capabilities directly influence export performance and indirectly through commitment and trust.Originality/valueTo the best of the authors’ knowledge, this study is among the first to attempt to use an integrated model (resource-based view and commitment-trust theory) to understand and explain an international marketing phenomenon. By concentrating on Ghana, the study offers new insights regarding the pathway for exporting firms in emerging markets.
A template-based approach to measure supply chain flexibility: a case study of Indian soap manufacturing firm
Authors: Singh Rohit Kumar , Acharya Padmanav , Modgil Sachin 
Published: April 2020

Purpose
The purpose of this study is to quantify the supply chain flexibility for an Indian soap manufacturing firm and to measure its performance. The authors made an attempt to find key strategic and operational decision-making dimensions for developing effective supply chain flexibility environment.

Design/methodology/approach
The authors have extracted 11 supply chain flexibility dimensions through extensive literature review. The authors used a decision-making trial and evaluation laboratory (DEMATEL) to make causal analysis and prioritizing the dimensions. After DEMATEL analysis three major supply chain flexibility dimensions that seem to have significant amount of influence on supply chain performance of the firms were retained for further consideration. The authors have developed an excel-based template for quantitative assessment of flexibility performance indicators.

Findings
This study provides key enablers for the successful implementation of flexibility concepts in Indian soap manufacturing firms and gives a view how to measure the performance through designing template based on real data. This template can be used in other firms also by simply modifying the key attributes.

Originality/value
A flexibility index has been defined here with the purpose of assessing the level of flexibility vis-a-vis what is desired and is meant to be evaluated from time to time, to assess if the firm is improving its flexibility or not. The index assumes importance in view of the fact that it has been prepared based on feedbacks of both the upper and the lower management people of the firm engaged in policymaking and operations.
The effects of moral/social identity threats and affirmations on psychological defensiveness following wrongdoing
Authors: Wenzel Michael , Woodyatt Lydia , McLean Ben 
Published: April 2020

Defensive responses to transgressions can have a negative impact on decision‐making within government and organizations, on relationships, and even an individual’s well‐being. Transgressors who are defensive are less likely to acknowledge or appreciate the extent of harm caused, and their responsibility in having contributed to it or in helping to repair it. It is therefore important to understand what situational factors increase or reduce defensiveness and, thus, offer solutions for those trying to foster responsibility‐taking by individuals in relationships, organizations, and society. This paper presents two studies exploring what underpins defensive responses in the context of transgressions. In Study 1 (N = 202), participants recalled an interpersonal transgression, and in Study 2 (N = 143), omnivorous participants watched a guilt‐eliciting documentary about meat production practices. Both studies demonstrate that defensiveness increases in response to social/moral threat. Further, Study 2 demonstrates that this defensiveness can be reduced by addressing the underlying threat to social/moral identity via value affirmation, encouraging moral engagement, and repair.
Activated monocytes and markers of inflammation in newly diagnosed multiple sclerosis
Authors: Carstensen Mikkel , Christensen Tove , Stilund Morten , Møller Holger J , Petersen Eva L , Petersen Thor 
Published: April 2020

AbstractIn multiple sclerosis (MS), the inflammation and demyelination of the central nervous system (CNS) develop in distinct ways. This makes diagnosing patients difficult, imperative to initiating early and proper treatment. Several common features exist, among them a profound infiltration of monocytes into the CNS mediating demyelination and tissue destruction. In the periphery, monocytes are divided into three subsets depending on expression of CD14 and CD16, representing different stages of activation and differentiation. To investigate their involvement in MS, peripheral blood mononuclear cells (PBMCs) from 61 patients with incipient, untreated MS and 22 symptomatic control (SC) patients as well as 6 patients with radiologically isolated syndrome (RIS) were characterized ex vivo. In addition, paired serum and cerebrospinal fluid (CSF) samples were analyzed with a panel of biomarkers. In PBMC samples, we demonstrate decreased levels of nonclassical monocytes with a concomitant significant decrease of human endogenous retrovirus (HERV) H3 envelope epitopes on this monocyte subset compared with SC and RIS. The observed HERV expression is present on nonclassical monocytes irrespective of MS and thus presumably a result of the inflammatory activation. For the other surface markers analyzed, we found significantly decreased expression between classical and nonclassical monocytes. In matched samples of CSF a highly significant increase in levels of soluble markers of activation and inflammation is shown, and notably this is not the case for the serum samples. Of the soluble markers investigated, interleukin (IL)‐12/IL‐23p40 had the highest discriminatory power in differentiating patients with MS from SC and RIS, almost comparable to the immunoglobulin G index.
Risk factors and the potential of nomogram for predicting hospital‐acquired pressure injuries
Authors: Cheng Hong , Sun Xiuming , Ji Xiaojun , Zhang Jidong , Lv Jinglei , Li Tianjun , Ding Lei 
Published: April 2020

AbstractThis 1:5 case‐control study aimed to identify the risk factors of hospital‐acquired pressure injuries (HAPIs) and to develop a mathematical model of nomogram for the risk prediction of HAPIs. Data for 370 patients with HAPIs and 1971 patients without HAPIs were extracted from the adverse events and the electronic medical systems. They were randomly divided into two sets: training (n = 1951) and validation (n = 390). Significant risk factors were identified by univariate and multivariate analyses in the training set, followed by a nomogram constructed. Age, independent movement, sensory perception and response, moisture, perfusion, use of medical devices, compulsive position, hypoalbuminaemia, an existing pressure injury or scarring from a previous pressure injury, and surgery sufferings were considered significant risk factors and were included to construct a nomogram. In both of the training and validation sets, the areas of 0.90 under the receiver operating characteristic curves showed excellent discrimination of the nomogram; calibration plots demonstrated a good consistency between the observed probability and the nomogram's prediction; decision curve analyses exhibited preferable net benefit along with the threshold probability in the nomogram. The excellent performance of the nomogram makes it a convenient and reliable tool for the risk prediction of HAPIs.
ЗАСТОСУВАННЯ ПСИХОДІАГНОСТИЧНИХ МЕТОДІВ ДЛЯ ВИЯВЛЕННЯ ПЕРВИННОГО ЕПІЗОДУ БІПОЛЯРНОГО АФЕКТИВНОГО РОЗЛАДУ В ПРАКТИЦІ ОХОРОНИ ЗДОРОВ’Я
Authors: Mysula Yu. I. 
Published: April 2020

Мета: вивчити найпоширеніші методи діагностики розладів біполярного спектра при первинному епізоді біполярного афективного розладу (БАР).
Матеріали і методи. Клінічно обстежено 153 хворих із первинним епізодом біполярного афективного розладу з використанням опитувальника розладів настрою (Mood Disorser Questionnaire – MDQ) (R. M. Hirschfield et al., 2001), діагностичної шкали біполярного спектра (N. S. Ghaemi, C. J. Miller et al., 2005; G. Sachs, 2004, 2008) та самоопитувальника для діагностики гіподинамії (Hypomania Checklist-32 – HCL-32).
Результати. Особливості перебігу первинного епізоду біполярного афективного розладу проаналізовано на основі даних клінічного обстеження 153 хворих. Встановлено, що найвищий діагностичний потенціал має діагностична шкала біполярного спектра у хворих із депресивним, маніакальним і змішаним варіантами первинного епізоду біполярного афективного розладу та нижчою здатністю опитувальника розладів настрою (MDQ) і самоопитувальника HCL-32 для діагностики патологічних афективних симптомів біполярного спектра в хворих із маніакальним та змішаним варіантом первинного епізоду біполярного афективного розладу, але вони були нечутливі до депресивного варіанту. Використовуючи діагностичну шкалу біполярного спектра для виявлення ознак біполярності при первинному епізоді БАР, варто памʼятати, що кількісні показники для неї нижчі, ніж при обстеженні хворих із клінічно сформованим БАР, що необхідно враховувати під час проведення діагностики.
Висновки. Виявлені особливості варто враховувати при використанні цих психодіагностичних інструментів для оцінки ризику біполярності при афективних розладах у клінічній практиці.
A novel p.A191D matrilin-3 variant in a Vietnamese family with multiple epiphyseal dysplasia: a case report
Authors: Ho Thuong Thi , Tran Linh Huyen , Hoang Lan Thu , Doan Phuong Kim Thi , Nguyen Trang Thi , Nguyen Trang Hong , Tran Hoai Thu , Hoang Ha , Chu Ha Hoang , Luong Anh Lan Thi 
Published: April 2020

Abstract
Background
Multiple epiphyseal dysplasia (MED) is a common skeletal dysplasia that is characterized by variable degrees of epiphyseal abnormality primarily involving the hip and knee joints. Mutations in a gene encoding matrilin-3 (MATN3) have been reported as disease causing of autosomal dominant MED. The current study identified a novel c.572 C > A variant (p.A191D) in exon 2 of MATN3 in a Vietnamese family with MED.

Case presentation
A standard clinical tests and radiological examination were performed in an 8-year-old Vietnamese girl patient. The clinical examination showed that patient height was under average, with bent lower limbs, limited mobility and dislocation of the joints at both knees. Radiological documentation revealed abnormal cartilage development at the epiphysis of the femur and patella. The patient has a varus deformity of the lower limbs. The patient was diagnosed with autosomal dominant MED using molecular testing in the order of the coding sequences and flanking sequences of five genes: COMP (exons 8–19), MATN3 (exon 2), COL9A2 (exon 3), COL9A3 (exon 3), COL9A1 (exon 8) by Sanger sequencing. A novel heterozygous missense variant (c.572 C > A, p.A191D) in MATN3 was identified in this family, which were not inherited from parents. The p.A191D was predicted and classified as a pathogenic variant. When the two predicted structures of the wild type and mutant matrilin-3 were compared, the p.A191D substitution caused conformational changes near the substitution site, resulting in deformity of the β-sheet of the single A domain of matrilin- 3.

Conclusions
This is the first Vietnamese MED family attributed to p.A191D matrilin-3 variant, and our clinical, radiological and molecular data suggest that the novel de novo missense variant in MATN3 contributed to MED.
Computational Methods in Problems of Subjective Assessment of Investment Decisions Effectiveness
Authors: Danko E.V. , Yergaliyev Ye.K. , Madiyarov M.N. 
Published: April 2020

The paper describes the implementation of investment projects under conditions of uncertainty. In the developed mathematical model, the effectiveness of an investment project is evaluated by the NPV index. This index is considered a random variable that can be estimated by an investor to within a segment [NPV1;NPV2]. The main difficulties of the decision-making process arise when the segment [NPV1;NPV2] includes zero value. In the developed model, we use the probability density function of NPV value in the form of Pearson curves of the first type. This paper discusses in detail some particular moments, which are to be taken into consideration while choosing a specific type of probability density function of NPV.
The main element of the proposed model is the subjective utility function. Many questions regarding the usage of this function in practice are also extensively reviewed in this article. The main requirement for successful usage of the subjective utility function in real life is a well-calculated chapter of scenario analysis of an investment project. This chapter is present in almost all modern business plans. The practical application of the developed mathematical model improves the quality of decisions concerning the investment of funds into projects.
Azidophenylselenylation of glycals towards 2-azido-2-deoxy-selenoglycosides and their application in oligosaccharide synthesis
Authors: Kazakova Ekaterina D. , Yashunsky Dmitry V. , Khatuntseva Elena A. , Nifantiev Nikolay E. 
Published: April 2020

Abstract
2-Amino-2-deoxy-pyranosyl units are important structural components of cell-wall polymers in prokaryotes, fungi and mammals. With respect to the need for development of novel and efficient vaccines and tools for serodiagnosis of infectious diseases, of particular interest are the oligosaccharide cell-wall antigens of pathogenic bacteria and fungi, which comprise 2-amino-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-galactopyranose units as α- or β-anomers. Synthesis of N-acylated α-GlcN and α-GalN containing oligosaccharides is a special challenge due to the presence of a participating group at C2 which favors the formation of β- rather than α-glycoside bond. Herein we overview the efficient two-step approach for preparation of 1,2-cis-glycosides of 2-amino-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D-galactopyranose, which was recently developed in our laboratory. In the first step, an efficient and straightforward azidophenylselenylation procedure of glycals gives phenyl 2-azido-2-deoxy-1-selenoglycosides as versatile glycosyl donors. In the second step, these donors can be efficiently transformed into α- or β-glycosides depending on the choice of the solvent. In acetonitrile, total β-stereocontrol was achieved, and the use of diethyl ether as a solvent favouring α-stereoselectivity of glycosylations with phenyl 2-azido-2-deoxy-1-selenoglycosides. Besides, it was shown, that low reactivity and nucleophilicity of glycosyl acceptors which are glycosylated with phenyl 2-azido-2-deoxy-1-selenogalactosides facilitated the formation of α-GalN derivatives. To date, homogenous azidophenylselenylation of glycals and glycosylation with phenyl 2-azido-2-deoxy-1-seleno-α-D-glycopyranosides can be regarded as most useful tool for introduction of 2-amino-2-deoxy-D-glycopyranoside residues into complex synthetic oligosaccharides.
КОНСТРУКТ «ЗОВНІШНЄ Я» ЯК КОМПОНЕНТ СОЦІАЛЬНОЇ САМОСВІДОМОСТІ ТА ДИСПОЗИЦІЙНА ОСНОВА СОЦІАБЕЛЬНОЇ ПОВЕДІНКИ: СПРОБА ТЕОРЕТИЧНОЇ ВАЛІДИЗАЦІЇ
Authors: Шамне Анжеліка 
Published: April 2020

Стаття містить спробу теоретичної валідизації емпіричного конструкту «зовнішнє Я», отри­ма­ного в результаті факторизації даних діагностики респондентів підліткового та юнацького віку (n=1457). Виокремлено декілька імпліцитних та експліцитних ліній аналізу цього конструкту: диспозиційну, соціаль­но-поведінкову та вікової генези. Проаналізовано експліцитні уявлення про соціабельність як характерис­ти­ку темпераменту та особистісну рису. Показано, що імпліцитно конструкт «зовнішнє Я» існує у психо­логії в різних іпостасях: як підструктура Я та прояв соціальної самосвідомості, як феномен ідентифікації та прояв потреби «бути як інші», як ціннісно-мотиваційна складова прагнення до любові, мотивації афі­ліації, страху осуду та бажання заслужити любов та схвалення оточення, як складова нормативної, кон­формної поведінки, як мотиваційний регулятор діяльності та життєдіяльності особистості. «Зовнішнє Я», з одного боку, є індивідуально-психологічною диспозицією, симптомокомплексом рис особистості, яку мож­на інтерпретувати як диспозиційну основу соціабельної поведінки. З іншого боку, конструкт «зовнішнє Я» має поведінкову складову – власне соціабельну поведінку. Її визначено як здатність особистості узго­джувати та коректувати соціальну активність згідно з очікуваннями оточення, групи, соціальними нор­ма­ми та вимогами. Як індивідуально-психологічна диспозиція «зовнішнє Я» є кластером взаємопов’язаних характеристик особистості (когнітивних, регулятивних, поведінкових), які відіграють важливу роль у процесі соціально-психологічної адаптації. Поведінкова складова «зовнішнього Я» (соціабельна поведінка) є опосередкованим показником соціоцентричних тенденцій розвитку (на противагу егоцентричним як орієнтації на власні цінності та сенси). Розглянуто особливості «зовнішнього Я» як позивної та негативної конотації особистості, його потенціал та ризики у розвитку особистості в період дорослішання. Ви­значено, що конструкт «зовнішнє Я» не є артефактом і може бути інтерпретований як вікова та со­ціально-психологічна характеристика прояву соціального в особистості у період підліткового та юнацького віку