bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraepithelial matrix metalloproteinase-9 in invasive breast carcinoma, normal tissue adjacent to tumor, and normal mammoplasty specimens: a comparative study considering relationship between matrix metalloproteinase-9 and some clinicopathologic prognostic factors of breast carcinoma
Authors: Mohammadizadeh Fereshteh , Dehkordi Mahsa Bagherian 
Published: March 2020

Abstract
Background- Matrix metalloproteinase-9 (MMP-9), an enzyme with major role in remodeling of extracellular matrix, has been the focus of attention in some previous studies in the field of breast cancer. We conducted a comparative study to investigate the frequency of this marker in tissue specimens of invasive breast carcinoma, tumor control, and normal control. The relationship between matrix metalloproteinase-9 and some clinicopathologic factors of breast carcinoma has also been evaluated. Methods- Formalin-fixed and paraffin-embedded tissue specimens from three groups including 40 invasive breast carcinoma (tumor group) and their adjacent normal tissue (tumor control), as well as 40 normal mammoplasty specimens (normal control) were studied. The samples were from the pathology archive of Alzahra Hospital, Isfahan, Iran, from 2016 to 2018. The status of intraepithelial MMP-9 was studied and compared in these three groups using immunohistochemistry. The relationship between intraepithelial MMP-9 and some clinicopathologic prognostic factors was also evaluated in tumor group. Results - The extent of intraepithelial MMP-9 immunostaining in all positive specimens was 100%. The results of intraepithelial MMP-9 staining intensity was as follow: 12.5% strong, 27.5% moderate, 27.5% mild, and 32.5% negative in tumor group; 17.5% strong, 22.5% moderate, 32.5% mild, and 27.5% negative in tumor control group; and 10% strong, 40% moderate, 27.5% mild, and 22.5% negative in normal control group. Intraepithelial MMP-9 immunostaining intensity showed significant difference between tumor and tumor control groups (P<0.001). Intraepithelial MMP-9 immunostaining intensity showed no significant difference between tumor and normal control groups, and between tumor control and normal control groups (P>0.05).
Effects of information-dependent vaccination behavior on coronavirus outbreak: insights from a SIRI model
Authors: Buonomo Bruno 
Published: March 2020

Abstract
A mathematical model is proposed to assess the effects of a vaccine on thetime evolution of a coronavirus outbreak. The model has the basic structure of SIRIcompartments (susceptible-infectious-recovered-infectious) and is implemented by tak-ing into account of the behavioral changes of individuals in response to the availableinformation on the status of the disease in the community. We found that the cumu-lative incidence may be significantly reduced when the information coverage is highenough and/or the information delay is short, especially when the reinfection rate ishigh enough to sustain the presence of the disease in the community. This analysis is in-spired by the ongoing outbreak of a respiratory illness caused by the novel coronavirusCOVID–19.
Characterization of modified mineral waste material adsorbent as affected by thermal treatment for optimizing its adsorption of lead and methyl orange
Authors: Su Lingcheng , Chen Jiajun , Ruan Huada , Chen Dongqi , Chen Xi , Lee Chiuhong 
Published: March 2020

AbstractThermal treatment is one of the most common processes in mineral modification, and this process has been applied to the modification of mineral waste material to improve its adsorption ability of methyl orange (MO) and lead (Pb) in this study. The properties of modified mineral waste material (MMWM) before and after thermal modification were characterized by using the Brunauer–Emmett–Teller (BET) N2 adsorption/desorption measurement, field emission scanning electron microscope (FESEM) coupled with energy-dispersive X-ray (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Phase transformation was investigated related to the change in surface morphology and dehydroxylation that occurred in MMWM samples during the process of thermal treatment. To study adsorption performances of Pb and MO onto the newly modified MMWM, several experiments were carried out under different adsorption conditions and the results were determined using inductively coupled plasma optical emission spectrometry (ICP-OES) and UV-Vis spectrophotometry. The thermally treated MMWM samples showed morphological transformation and an increasing trend in BET specific surface area (SSA) up to 500 °C followed by a decreasing trend till 1000 °C. Thermal modification of MMWM successfully improved Pb adsorption from 349 to 515 mg/g, corresponding to the MMWM modified at 600 °C, and the methyl orange (MO) adsorption from 68 to 87.6 mg/g at 400 °C. The adsorptions of Pb and MO were mainly chemisorption and monolayer coverage, as the pseudo-second-order model and the Langmuir equation displayed good correlations for Pb and MO adsorption data.
Some geometrical properties of fission-track-surface intersections in apatite
Authors: Jonckheere Raymond , Aslanian Carolin , Wauschkuhn Bastian , Ratschbacher Lothar 
Published: March 2020

Abstract
Parallel fission-track-surface intersections identify the grains in an etched apatite mount that have been polished parallel to their prism faces and mark the orientations of their c-axes. Their lengths (Dpar) are a practical kinetic parameter that is indicative of the track annealing rate of apatite. Little is known, however, about their geometrical properties in non-prism faces. We present a model calculation of the frequency distributions of the orientations, lengths, and widths of track-surface intersections in non-prism faces. The current model does not include the effects of surface etching or measurement imprecision. However, as far as it goes, it is consistent with measurements in apatite surfaces up to 30° to the c-axis. Regardless of the model, we submit that the statistical properties of the fission-track-surface intersections have practical uses. The distribution of their orientations is characteristic of the orientation of the etched surface relative to the c-axis. The distribution of their lengths presents a possible tool for investigating track etching, in particular for evaluating the tracks added and lost through surface etching. The distribution of their widths is a potential kinetic parameter independent of surface orientation and less susceptible to the factors, such as the sampling method and surface etch rate, that produce conflicting Dpar values.
Utility of Biodiesel in Diesel Engine
Authors: Islam Md. Zahidul , Onny Nusrat Jahan , Chowdhury Suman 
Published: March 2020

The energy resources from the fossil fuels are decreasing day by day. Rather fossil fuel is costly, it creates environmental problems by producing and NOx in the environment. Now it is argent to find a solution. The solution can be renewable energy. In this paper the effort was to find the utility of biodiesels in the conventional diesel engine. This biofuel or biodiesel is extracted from Soybean methyl ester (SME). We compared the basic performance characteristics diesel, SME 20 and SME 100 in unmodified diesel engine. This experiment will be helpful to find out the utility of SME type biodiesel in conventional diesel engine so that the uses of fossil fuels can be reduced in quick rental power plants and other uses. We can use biodiesel as substitute in an economic tariff and efficient way. The energy resources from the fossil fuels are decreasing day by day. Rather fossil fuel is costly, it creates environmental problems by producing and NOx in the environment. Now it is argent to find a solution. The solution can be renewable energy. In this paper the effort was to find the utility of biodiesels in the conventional diesel engine. This biofuel or biodiesel is extracted from Soybean methyl ester (SME). We compared the basic performance characteristics diesel, SME 20 and SME 100 in unmodified diesel engine. This experiment will be helpful to find out the utility of SME type biodiesel in conventional diesel engine so that the uses of fossil fuels can be reduced in quick rental power plants and other uses. We can use biodiesel as substitute in an economic tariff and efficient way.
A review of flux identification methods for models of sedimentation
Authors: Bürger R. , Careaga J. , Diehl S. 
Published: March 2020

Abstract
Most models of sedimentation contain the nonlinear hindered-settling flux function. If one assumes ideal conditions and no compression, then there exist several theoretically possible ways of identifying a large portion of the flux function from only one experiment by means of formulas derived from the theory of solutions of partial differential equations. Previously used identification methods and recently published such, which are based on utilizing conical vessels or centrifuges, are reviewed and compared with synthetic data (simulated experiments). This means that the identification methods are evaluated from a theoretical viewpoint without experimental errors or difficulties. The main contribution of the recent methods reviewed is that they, in theory, can identify a large portion of the flux function from a single experiment, in contrast to the traditional method that provides one point on the flux curve from each test. The new methods lay the foundation of rapid flux identification; however, experimental procedures need to be elaborated.
Virtual Screening of the Multi-pathway and Multi-gene Regulatory Molecular Mechanism of Dachengqi Decoction in the Treatment of Stroke Based on Network Pharmacology
Authors: Pei Lishan , Shen Xia , Yan Yonggang , Tan Conge , Qu Kai , Zou Junbo , Wang Yanxia , Ping Fan 
Published: March 2020

Background:
Stroke is ranked second among diseases that cause mortality worldwide.
Owing to its complicated pathogenesis, no satisfactory treatment strategies for stroke are available.
Dachengqi decoction (DCQD), a traditional Chinese herbal medicine, has been widely used in
China for a long time, as it has a good effect on stroke. However, the molecular mechanism
underlying this effect of DCQD is unclear.

Objective:
In the present study, we aimed to reveal and explore the multi-pathway and multi-gene
regulatory molecular mechanism of Dachengqi decoction in the treatment of stroke.

Methods:
In this study, a network pharmacology method, in combination with oral bioavailability
prediction and drug-likeness evaluation, was employed to predict the active ingredients of DCQD.
The target genes of the active components and the traced pathways related to these target genes
were predicted. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway analyses were performed using clusterProfiler software package on the R
platform and ClueGo+CluePedia plug-ins. Finally, the key DCQD targets were verified using the
Gene Expression Omnibus (GEO) dataset.

Results and Discussion:
According to the ADME model, 52 active components were screened
from 296 active components of DCQD. After prediction and screening, 215 stroke-related targets
were obtained and analyzed via GO and KEGG analyses. GO analysis showed that DCQD targets
were mainly involved in the regulation of oxidative stress, lipid metabolism, inflammation, and
other biological processes. KEGG pathway analysis further revealed pathways involved in stroke,
such as arachidonic acid metabolic, HIF-1 signaling pathway, estrogen signaling pathway, MAPK
signaling pathway, PI3K-Akt signaling pathway, platelet activation pathway, VEGF signaling
pathway, and cAMP signaling pathway. Network analysis revealed that DCQD might be involved
in the regulation of lipid metabolism, blood pressure, inflammation, angiogenesis, neuroprotection,
platelet aggregation, apoptosis, and oxidation in stroke treatment. GEO dataset analysis showed
that DCQD’s therapeutic effects might be exerted via the bidirectional regulation principle.

Conclusion:
Based on the methods of network pharmacology and GEO analysis, it was found that,
during stroke treatment, DCQD regulates and controls multiple genes and multiple pathways in a
synergistic manner, providing a new strategy for stroke treatment.
Immunotherapy and Radiation Therapy in Renal Cell Carcinoma
Authors: Mollica Veronica , Santoni Matteo , Di Nunno Vincenzo , Cimadamore Alessia , Cheng Liang , Lopez-Beltran Antonio , Battelli Nicola , Montironi Rodolfo , Massari Francesco 
Published: March 2020

Background:The management of renal cell carcinoma is rapidly evolving and immunotherapy, mostly consisting of immune checkpoint inhibitors, is revolutionizing the treatment scenario of metastatic patients. Novel fractionation schedules of radiotherapy, consisting of high doses in few fractions, can overcome the radioresistance of this tumor. Localized radiotherapy is associated with a systemic effect, known as the abscopal effect. This effect mediated by the immune system can be enhanced associating radiotherapy with immunotherapy.Objective:In this review, we explore the role of radiotherapy and immunotherapy in RCC, the rationale of combining these strategies and the on-going clinical trials investigating combinations of these two treatment modalities.Conclusion:Combining immunotherapy and radiotherapy has a strong rationale and pre-clinical studies support their association because it can overcome the immunosuppression of the tumor microenvironment and increase the anti-tumor immune response. More clinical evidence, deriving from onclinical trials, are needed to prove the efficacy and safety of these treatments combined.
In Silico and In Vitro Studies of Natural Compounds as Human CK2 Inhibitors
Authors: Haidar Samer , Jürgens Franziska , Aichele Dagmar , Jose Joachim 
Published: March 2020

Background:
Casein Kinase 2 (CK2) is a ubiquitous cellular serine-threonine kinase
with broad spectrum of substrates. This enzyme is widely expressed in eukaryotic cells and is overexpressed
in different human cancers. Thus, the inhibition of CK2 can induce the physiological
process of apoptosis leading to tumor cell death.

Objective:
Selecting natural inhibitors toward the target enzyme using database mining.

Method:
With our continuous effort to discover new compounds with CK2 inhibitory effect, several
commercial natural databases were searched using molecular modeling approach and the selected
compounds were evaluated in vitro.

Result:
Three compounds were selected as candidates and evaluated in vitro using CK2 holoenzyme,
their effect on three cancer cell lines was determined. The selected candidates were weak inhibitors
toward the target enzyme, only one compound showed moderate effect on cell viability.

Conclusion:
Several natural databases were screened and compounds were selected and tested in vitro, despite of the unexpected low activity of the compounds, this study can help in directing the search of potent CK2 inhibitors and better understand the binding requirements of the ATP competitive inhibitors.
An Overview on Eco-Friendly Polymer Composites for Heavy Metal Ion Remediation
Authors: Nazir Muhammad Shahid , Palvasha Bushra Anees , Tahir Zaman , Hassan Sadaf ul , Ali Zulfiqar , Akhtar Majid Niaz , Azam Kashuf , Abdullah Mohd. Azmuddin 
Published: March 2020

Background:
Water contamination by noxious heavy metals due to urbanization is a global environmental problem. Heavy metal ions pollution make the water unsuitable for drinking and are also highly toxic to human beings and eco-system. Remediation of heavy metals is therefore very crucial.

Method:
Adsorbents based on biopolymer and eco-friendly polymer composites have been developed and fabricated to remediate and remove heavy metals from the ecosystem.

Result:
In recent years, biocomposites have been successful as cost effective adsorbents for the remediation of various contaminants with their eco-friendly nature and sustainability.

Conclusion:
This review article gives an overview on the remediation of heavy metals using green biocomposites.
GAMEBOOK E A ESTIMULAÇÃO DE FUNÇÕES EXECUTIVAS EM CRIANÇAS COM INDICAÇÃO DE DIAGNÓSTICO DE TDAH
Authors: Alves Lynn , Bonfim Camila 
Published: March 2020

Este artigo objetiva descrever o processo de desenvolvimento do Gamebook, uma mídia híbrida com características de jogo digital e appbook, desenvolvido para estimular as Funções Executivas (FE) de crianças na faixa etária de 8 a 12 anos especialmente com diagnóstico de Transtorno de Déficit de Atenção e Hiperatividade (TDAH). A metodologia foi de base qualitativa, dialogando com a perspectivamultirreferencial, exploratória e descritiva, com prática colaborativa mediada com os distintos saberes nas reuniões entre os membros da equipe e pesquisadores/especialistas parceiros. Para identificar o perfil das crianças que interagem com a cultura digital e apresentam diagnóstico de TDAH utilizamos questionário on-line, respondido coma mediação de pais e especialistas. Isso subsidiou o desenvolvimento, avaliação e retroalimentação do gamebook, concretizando-se em ambiente interativo com 8 minigames. O gamebook encontra-se disponível, gratuitamente, nas Appstores para tablet nos sistemas operacionais IOS e Android. O projeto encontra-se agora na fase deinvestigação com crianças com diagnóstico de TDAH, para avaliar a contribuição dos minigames ao estimular as FE. Assim, o artigo aqui proposto apresenta os resultados da primeira fase da investigação, que a partir da avaliação dos especialistas conclui que os ambientes interativos, como o gamebook, podem se constituir em lócus deaprendizagem e estimulação das FE.
Exploring the Characteristics and Behaviors of Nurses Who Have Attained Microcelebrity Status on Instagram: Content Analysis
Authors: Kerr Hanna , Booth Richard , Jackson Kimberley 
Published: March 2020

BackgroundInstagram is a social media platform that enables users to share images and videos worldwide. Some nurses have used Instagram to document their experiences as a nurse and have subsequently gained microcelebrity status—that is, a user who purposefully seeks to amass a substantive Web-based following and has become recognized as a niche area of interest.ObjectiveThis study aimed to identify the characteristics and behaviors of microcelebrity nurses who act as influencers on Instagram and use their nursing profile to gain attention and presence on the Web.MethodsA qualitative, exploratory, nonparticipatory content analysis of media and text generated by a purposeful sample of 10 registered nurses who use Instagram and sustain a definable microcelebrity status was conducted. In this study, manifest and latent data were examined to gain an understanding of the characteristics and behaviors of nurses who have attained microcelebrity status on Instagram.ResultsData analysis revealed 5 themes of Instagram posts: (1) engaging Instagram users, (2) educational opportunities and insights, (3) nursing-related humor, (4) emotions experienced by nurses, and (5) media and narratives including patient details or work context. Messages were primarily positive in nature; however, multiple potential privacy, ethical, and professional issues were noted throughout the posted content.ConclusionsThe findings of this study help to expand the current knowledge related to the use of social media platforms such as Instagram, especially in regard to the emergence of nurses who use this form of technology to achieve or maintain a microcelebrity status. This study calls for additional research on nurses’ attainment of microcelebrity status on social media as well as further policy development to adequately prepare nurses to navigate social media.
Experiences of Gamified and Automated Virtual Reality Exposure Therapy for Spider Phobia: Qualitative Study
Authors: Lindner Philip , Rozental Alexander , Jurell Alice , Reuterskiöld Lena , Andersson Gerhard , Hamilton William , Miloff Alexander , Carlbring Per 
Published: March 2020

Background
Virtual reality exposure therapy is an efficacious treatment of anxiety disorders, and recent research suggests that such treatments can be automated, relying on gamification elements instead of a real-life therapist directing treatment. Such automated, gamified treatments could be disseminated without restrictions, helping to close the treatment gap for anxiety disorders. Despite initial findings suggesting high efficacy, very is little is known about how users experience this type of intervention.

Objective
The aim of this study was to examine user experiences of automated, gamified virtual reality exposure therapy using in-depth qualitative methods.

Methods
Seven participants were recruited from a parallel clinical trial comparing automated, gamified virtual reality exposure therapy for spider phobia against an in vivo exposure equivalent. Participants received the same virtual reality treatment as in the trial and completed a semistructured interview afterward. The transcribed material was analyzed using thematic analysis.

Results
Many of the uncovered themes pertained directly or indirectly to a sense of presence in the virtual environment, both positive and negative. The automated format was perceived as natural and the gamification elements appear to have been successful in framing the experience not as psychotherapy devoid of a therapist but rather as a serious game with a psychotherapeutic goal.

Conclusions
Automated, gamified virtual reality exposure therapy appears to be an appealing treatment modality and to work by the intended mechanisms. Findings from the current study may guide the next generation of interventions and inform dissemination efforts and future qualitative research into user experiences.
CONSUMER PREFERENCES FOR INDONESIAN CULINARY
Authors: Ernawati Hani , Prakoso Dodik 
Published: March 2020

Introductions: Indonesia has many traditional types of food which makes it a preferred culinary tourism destination. The role of food in Indonesian culture is an expressive activity that reaffirms people’s social relations with life, and with trust, the economy, technology, and its various differences. Background Problems: Identify consumer’s preferences on Indonesian culinary, estimate the market share of Indonesian culinary, determine the most preferred culinary, and determine market segmentation of Indonesian culinary. Research Method: The conjoint analysis was used to evaluate and measure customers’ preferences for culinary design attributes included food origin, taste, freshness, price, and serving. Findings: The findings of this study were Indonesian food which most be preferred was in the combination of “salty & crispy, fresh, expensive, serving with waitress”, which most be preferred by consumer in the age between 25 years old and 40 years old, woman, originally from Europe, in the medium income level. Conclusion: Most consumers prefer “fresh food” more than “not fresh food”. With respect to the “price,” consumers prefer the cheapest culinary. The market share of Indonesian food viewed consumers who placed it as their most preferred was 28.85%, occupied at the second rank subsequently to western food.