bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secondary Ice Production upon Freezing of Freely Falling Drizzle Droplets
Authors: Keinert Alice , Spannagel Dominik , Leisner Thomas , Kiselev Alexei 
Published: August 2020

AbstractIce multiplication processes are known to be responsible for the higher concentration of ice particles versus ice nucleating particles in clouds, but the exact secondary ice formation mechanisms remain to be quantified. Recent in-cloud observations and modeling studies have suggested the importance of secondary ice production upon shattering of freezing drizzle droplets. In one of our previous studies, four categories of secondary ice formation during freezing of supercooled droplets have been identified: breakup, cracking, jetting, and bubble bursts. In this work, we extend the study to include pure water and an aqueous solution of analog sea salt drizzle droplets moving at terminal velocity with respect to the surrounding cold humid air. We observe an enhancement in the droplet shattering probability as compared to the stagnant air conditions used in the previous study. Under free-fall conditions, bubble bursts are the most common secondary ice production mode in sea salt drizzle droplets, while droplet fragmentation controls the secondary ice production in pure water droplets.
Convection-Permitting Regional Climate Simulations in the Arabian Gulf Region Using WRF Driven by Bias-Corrected GCM Data
Authors: Jing Xiaoqin , Xue Lulin , Yin Yan , Yang Jing , Steinhoff Daniel F. , Monaghan Andrew , Yates David , Liu Changhai , Rasmussen Roy , Taraphdar Sourav , Pauluis Olivier 
Published: August 2020

AbstractThe regional climate of the Arabian Gulf region is modeled using a set of simulations based on the Weather Research and Forecasting (WRF) Model, including a 30-yr benchmark simulation driven by reanalysis data, and two bias-corrected Community Earth System Model (CESM)-driven (BCD) WRF simulations for retrospective and future periods that both include 10-yr convection-permitting nested simulations. The modeled precipitation is cross-validated using Tropical Rainfall Measuring Mission data, rain gauge data, and the baseline dataset from the benchmark simulation. The changes in near-surface temperature, precipitation, and ambient conditions are investigated using the BCD WRF simulations. The results show that the BCD WRF simulation well captures the precipitation distribution, the precipitation variability, and the thermodynamic properties. In a warmer climate under the RCP8.5 scenario around the year 2070, the near-surface temperature warms by ~3°C. Precipitation increases over the Arabian Gulf, and decreases over most of the continental area, particularly over the Zagros Mountains. The wet index decreases while the maximum dry spell increases in most areas of the model domain. The future changes in precipitation are determined by both the thermodynamics and dynamics. The thermodynamic impact, which is controlled by the warming and moistening, results in more precipitation over the ocean but not over the land. The dynamic impact, which is controlled by changes in the large-scale circulation, results in decrease in precipitation over mountains. The simulations presented in this study provide a unique dataset to study the regional climate in the Arabian Gulf region for both retrospective and future climates.
Enhancing Autonomy for Climate Change Adaptation Using Participatory Modeling
Authors: Williams David Samuel 
Published: August 2020

AbstractParticipatory modeling is commonly applied in climate change adaptation research to integrate stakeholder knowledge, beliefs, values, and norms into modeling processes. However, participation is not neutral, and current climate change adaptation research is tailored toward those with sufficient resources to adapt, as opposed to those most in need of adaptation. These are commonly marginalized stakeholder groups who remain on the social, economic, and political periphery, driving their vulnerability to climate change impacts. This paper presents the concept of autonomy in the context of multilevel governance for climate change adaptation before examining past participatory modeling approaches, illustrating the lack of application as an emancipatory tool for increasing the autonomy of marginalized stakeholder groups. Therefore, a list of 10 necessary conditions is presented for conducting participatory modeling for increasing the autonomy of marginalized stakeholder groups, strengthening multilevel governance for climate change adaptation. These theoretical foundations are intended to guide public policy and increase the societal impact of participatory modeling.Significance StatementResponding to climate change impacts requires the strengthening of multilevel governance. An important aspect is that multilevel governance is dependent on local actors having sufficient autonomy to carry out climate change adaptation actions. Participatory climate change adaptation research can contribute to enhancing autonomy for climate change adaptation in applying participatory modeling. This paper explains why this is important, how participatory modelers need to design their research, and in what way this could contribute to strengthening multilevel governance and the wider societal response to climate change impacts.If you’re a scholar who studies the social impacts of climate change and you aren’t somehow an activist what are you really?—Professor Kian Goh, University of California, Los Angeles
Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials
Authors: Jin Bihui , Qian Lingbo , Fu Xiaohua , Zhu Jing , Shu Jing 
Published: August 2020

Objective Observational studies have shown that circulating vitamin D (VitD) deficiency is associated with atherogenic lipid patterns among polycystic ovary syndrome (PCOS) patients. However, interventional studies have shown inconsistent results. The aim of this meta-analysis was to investigate how VitD supplementation influences lipid indices in PCOS patients. Methods The authors searched four electronic databases through August 2019 to identify randomized controlled trials (RCTs) that assessed the effect of VitD intervention on serum lipids among PCOS patients. Mean differences were generated for statistical evaluation. Results We included eight studies and performed nine comparisons across 467 participants. VitD supplementation reduced serum triglyceride levels (−11.88 mg/dL; 95% confidence interval [CI]: −17.03 to −6.73), total cholesterol (−9.09 mg/dL; 95% CI: −14.90 to −3.29), low-density lipoprotein cholesterol (−5.22 mg/dL; 95% CI: −10.32 to −0.13), and very-low-density lipoprotein cholesterol (−2.43 mg/dL; 95% CI: −3.69 to −1.17) compared with no VitD supplementation. However, high-density lipoprotein cholesterol levels showed no differences with or without VitD supplementation (−0.39 mg/dL; 95% CI: −1.39 to 0.61). Conclusions VitD supplementation improved serum lipid levels among PCOS patients, but serum high-density lipoprotein cholesterol levels were not changed. VitD intervention might benefit PCOS patients who are at high risk of an atherogenic lipid profile.
Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells
Authors: Li Yachun , Li Dongjie , Wang Ping , Zhu Wei , Yin Wanzhong 
Published: August 2020

Objective Studies have demonstrated that tetrandrine reverses multidrug resistance (MDR) in animal models or cell lines derived from multiple cancer types. We examined the potential MDR reversal activity of tetrandrine in a multidrug-resistant variant of a human laryngeal cancer Hep-2 cell line and explored potential mechanisms involved. Methods We developed the multidrug-resistant variant cell line (Hep-2/v) by exposing Hep-2 cells to stepwise increasing concentrations of vincristine (VCR). After Hep-2 or Hep-2/v cells were treated with tetrandrine (2.52 µg/mL), MDR was measured by MTT assay, rhodamine 123 retention was measured by flow cytometry, and mRNA and protein expression of multidrug resistance 1 (MDR1), regulator of G-protein signaling 10 (RGS10), high-temperature requirement protein A1 (HTRA1), and nuclear protein 1 (NUPR1) were detected by real-time reverse transcription-PCR and western blotting, respectively. Results Tetrandrine significantly lowered the half-maximal inhibitory concentration (IC50) of VCR in Hep-2/v cells, resulting in a 2.22-fold reversal of MDR. Treatment with tetrandrine increased rhodamine 123 retention, downregulated the mRNA and protein expression of MDR1 and RGS10, and upregulated expression of HTRA1 in Hep-2/v cells. Conclusion We showed that tetrandrine exerts anti-MDR activity in Hep-2/v cells, possibly by inhibiting MDR1 overexpression-mediated drug efflux and by altering expression of HTRA1 and RGS10.
IGF-1 loaded injectable microspheres for potential repair of the infarcted myocardium
Authors: Rosellini Elisabetta , Barbani Niccoletta , Frati Caterina , Madeddu Denise , Massai Diana , Morbiducci Umberto , Lazzeri Luigi , Falco Angela , Graiani Gallia , Lagrasta Costanza , Audenino Alberto , Cascone Maria Grazia , Quaini Federico 
Published: August 2020

The use of injectable scaffolds to repair the infarcted heart is receiving great interest. Thermosensitive polymers, in situ polymerization, in situ cross-linking, and self-assembling peptides are the most investigated approaches to obtain injectability. Aim of the present work was the preparation and characterization of a novel bioactive scaffold, in form of injectable microspheres, for cardiac repair. Gellan/gelatin microspheres were prepared by a water-in-oil emulsion and loaded by adsorption with Insulin-like growth factor 1 to promote tissue regeneration. Obtained microspheres underwent morphological, physicochemical and biological characterization, including cell culture tests in static and dynamic conditions and in vivo tests. Morphological analysis of the microspheres showed a spherical shape, a microporous surface and an average diameter of 66 ± 17µm (under dry conditions) and 123 ± 24 µm (under wet conditions). Chemical Imaging analysis pointed out a homogeneous distribution of gellan, gelatin and Insulin-like growth factor-1 within the microsphere matrix. In vitro cell culture tests showed that the microspheres promoted rat cardiac progenitor cells adhesion, and cluster formation. After dynamic suspension culture within an impeller-free bioreactor, cells still adhered to microspheres, spreading their cytoplasm over microsphere surface. Intramyocardial administration of microspheres in a cryoinjury rat model attenuated chamber dilatation, myocardial damage and fibrosis and improved cell homing. Overall, the findings of this study confirm that the produced microspheres display morphological, physicochemical, functional and biological properties potentially adequate for future applications as injectable scaffold for cardiac tissue engineering.
Exploring Readiness for Teleprecepting in Psychiatric Mental Health Nurse Practitioner Training
Authors: Johnson Deborah S. , Ling Amanda , Melino Katerina 
Published: August 2020

OBJECTIVE: Telehealth offers a solution to many challenges in health care, including the shortage of psychiatric providers. Recently the need to limit patient and provider exposure to coronavirus disease 2019 (COVID-19) has escalated implementation of telehealth across the globe. As telehealth utilization expands, its role in nursing education and training requires systematic evaluation. Since publication of the National Organization of Nurse Practitioner Faculty white paper supporting telehealth in health care delivery and nurse practitioner education, several studies have demonstrated successful didactic instruction and training in telehealth. However, a recent literature review found no studies evaluating the use of telehealth technology as a means of precepting in clinical training. METHODS: This small-scale qualitative study investigates the readiness of one behavioral health clinic to provide teleprecepting to psychiatric mental health nurse practitioner students. Two preceptors and one student were interviewed using a peer-reviewed semistructured interview guide using video chat. Responses were reviewed, coded, and categorized into themes. RESULTS: Thematic analysis of the interviews revealed three categories for consideration in establishing teleprecepting. Clinical factors, logistics, and comparison with traditional precepting are discussed. Interviewees viewed teleprecepting as a viable method of increasing access to clinical training. CONCLUSIONS: This project supports teleprecepting as a feasible strategy for improving access to clinical training and as a technological resource that merits systematic evaluation. Practice guidelines are needed for teleprecepting of advanced practice registered nurse students, and both preceptors and students may benefit from training to support best practices prior to implementation.
Insights Provided by Depression Screening Regarding Pain, Anxiety, and Substance use in a Veteran Population
Authors: Stevens Elizabeth R. , Mazumdar Medha , Caniglia Ellen C. , Khan Maria R. , Young Kailyn E. , Edelman E. Jennifer , Gordon Adam J. , Fiellin David A. , Maisto Stephen A. , Chichetto Natalie E. , Crystal Stephan , Gaither Julie R. , Justice Amy C. , Braithwaite R. Scott 
Published: August 2020

Objective: We sought to quantify the extent to which a depression screening instrument commonly used in primary care settings provides additional information regarding pain interference symptoms, anxiety, and substance use. Methods: Veterans Aging Cohort Study (VACS) data collected from 2003 through 2015 was used to calculate odds ratios (OR) for associations between positive depression screening result cutoffs and clustering conditions. We assessed the test performance characteristics (likelihood ratio value, positive predictive value, and the percentage of individuals correctly classified) of a positive Patient Health Questionnaire (PHQ-9 & PHQ-2) depression screen for the identification of pain interference symptoms, anxiety, and substance use. Results: A total 7731 participants were included in the analyses. The median age was 50 years. The PHQ-9 threshold of ≥20 was strongly associated with pain interference symptoms (OR 21.6, 95% CI 17.5-26.7) and anxiety (OR 72.1, 95% CI 52.8-99.0) and yielded likelihood ratio values of 7.5 for pain interference symptoms and 21.8 for anxiety and positive predictive values (PPV) of 84% and 95%, respectively. A PHQ-9 score of ≥10 still showed significant associations with pain interference symptoms (OR 6.1, 95% CI 5.4-6.9) and symptoms of anxiety (OR 11.3, 95% CI 9.7-13.1) and yet yielded lower likelihood ratio values (4.36 & 8.24, respectively). The PHQ-9 was less strongly associated with various forms of substance use. Conclusion: Depression screening provides substantial additional information regarding the likelihood of pain interference symptoms and anxiety and should trigger diagnostic assessments for these other conditions.
Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis
Authors: Greiner Georg , Sprinzl Bettina , Górska Aleksandra , Ratzinger Franz , Gurbisz Michael , Witzeneder Nadine , Schmetterer Klaus G. , Gisslinger Bettina , Uyanik Goekhan , Hadzijusufovic Emir , Esterbauer Harald , Gleixner Karoline V. , Krauth Maria T. , Pfeilstöcker Michael , Keil Felix , Gisslinger Heinz , Nedoszytko Boguslaw , Niedoszytko Marek , Sperr Wolfgang R. , Valent Peter , Hoermann Gregor 
Published: August 2020

AbstractMastocytosis is a hematopoietic neoplasm characterized by expansion of KIT D816V-mutated clonal mast cells in various organs and severe or even life-threatening anaphylactic reactions. Recently, hereditary α-tryptasemia (HαT) has been described as a common genetic trait with increased copy numbers of the α-tryptase encoding gene, TPSAB1, and associated with an increased basal serum tryptase level and a risk of mast cell activation. The purpose of our study was to elucidate the clinical relevance of HαT in patients with mastocytosis. TPSAB1 germline copy number variants were assessed by digital polymerase chain reaction in 180 mastocytosis patients, 180 sex-matched control subjects, 720 patients with other myeloid neoplasms, and 61 additional mastocytosis patients of an independent validation cohort. α-Tryptase encoding TPSAB1 copy number gains, compatible with HαT, were identified in 17.2% of mastocytosis patients and 4.4% of the control population (P &lt; .001). Patients with HαT exhibited higher tryptase levels than patients without HαT (median tryptase in HαT+ cases: 49.6 ng/mL vs HαT− cases: 34.5 ng/mL, P = .004) independent of the mast cell burden. Hymenoptera venom hypersensitivity reactions and severe cardiovascular mediator-related symptoms/anaphylaxis were by far more frequently observed in mastocytosis patients with HαT than in those without HαT. Results were confirmed in an independent validation cohort. The high prevalence of HαT in mastocytosis hints at a potential pathogenic role of germline α-tryptase encoding TPSAB1 copy number gains in disease evolution. Together, our data suggest that HαT is a novel emerging robust biomarker in mastocytosis that is useful for determining the individual patient´s risk of developing severe anaphylaxis.
Prospective long-term follow-up after first-line subcutaneous cladribine in hairy cell leukemia: a SAKK trial
Authors: Benz Rudolf , Arn Kornelius , Andres Martin , Pabst Thomas , Baumann Michael , Novak Urban , Hitz Felicitas , Hess Urs , Zenhaeusern Reinhard , Chalandon Yves , Mey Ulrich , Blum Sabine , Rauch Daniel , O'Meara Stern Alix , Cantoni Nathan , Bargetzi Mario , Bianchi-Papina Elena , Rossi Davide , Passweg Jakob , Lohri Andreas , Berardi Simona , Li Qiyu , Feller Anita , Stussi Georg 
Published: August 2020

AbstractHairy cell leukemia (HCL) remains an incurable disease. However, first-line treatment with either intravenous or subcutaneous cladribine generally leads to long-lasting remissions. Although there are excellent long-term data for intravenous application, similar data regarding subcutaneous administration are lacking. We therefore analyzed the long-term outcome of 3 prospective multicenter clinical trials on subcutaneous cladribine performed by the Swiss Group for Clinical Cancer Research (SAKK), which recruited 221 patients with classical HCL between 1993 and 2005. Median overall survival from start of treatment was not reached. Pretreatment anemia, higher Eastern Cooperative Oncology Group score, and higher age were associated with poorer overall survival in multivariable analysis, whereas early progression at 24 and 36 months had no significant impact on overall survival. Second-line treatment was necessary in 53 (23.7%) patients after a median of 5 (range, 0.2-20.4) years, and first retreatment was mainly monotherapy with cladribine (66%) or rituximab (15.1%) or a combination of these drugs (15.1%). A total of 44 (19.9%) patients developed second primary malignancies with a median time to occurrence of 5.7 (range, 0.01-17.5) years. Second primary malignancies were the main cause for death (14; 27.5%). Compared with a matched normal Swiss population, the incidence of second primary malignancies was not increased. However, survival of patients with HCL was slightly inferior by comparison (P = .036). In conclusion, the outcome of HCL patients treated with subcutaneous cladribine is excellent, and in most patients, 1 cycle of subcutaneous cladribine is sufficient for long-term disease control.
UV protection for young athletes: using participatory program planning to develop a sports schools program
Authors: Stölzel Friederike , Wolff Michaela , Fieber Vera , Glausch Melanie , Wachs Claudia , Breitbart Eckhard , Bornhäuser Martin , Seidel Nadja 
Published: August 2020

Abstract
Background
The incidence of melanoma increased rapidly throughout the last decades, with overexposure to ultraviolet (UV) radiation being an established risk factor. Due to their intensive sun exposure, many student athletes (SAs) have an increased risk for skin cancer. The Clever in Sun and Shade Program (CSSP) aims at enforcing positive attitudes toward UV protection (UVP) and at supporting sports schools in establishing UVP strategies.

Methods
CSSP was developed in 2019 using participatory program planning (PPP) as well as following WHO recommendations for UVP at schools. After drafting first material, within a PPP groups were conducted at a partner school (convenience sample 1) with students (n = 20), teachers (n = 5), school administration (n = 2), and coaches (n = 5). Materials were then adapted. Program acceptance and feasibility were tested at two further schools (convenience sample 2) with PPP groups of students (n = 95) and school administration (n = 2). Content analyses and descriptive statistics were conducted.

Results
Less than 50% of SAs and coaches of sample 1 expressed positive attitudes toward UVP, less than 10% reported appropriate UVP behavior. By using PPP, program material was adapted to the target groups’ needs, i.e., by including specific barriers and solutions. Only the most accepted video drafts were produced. The majority of SAs of sample 2 (80-86%) used predominantly positive adjectives such as “important” and “positive” to describe the completed videos and the behavior self-check poster.

Conclusions
PPP process has greatly influenced concept and materials of CSSP for sports schools. Integration of future program participants has proven to be an important component in creating a fitting and feasible program. CSSP for sports schools is a program free of charge that enables sports schools to integrate UVP into their daily routine. It will be disseminated in cooperation with German Olympic Sports Confederation and German Cancer Aid in 2021.
ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network
Authors: Atallah Michelle B. , Tandon Varun , Hiam Kamir J. , Boyce Hunter , Hori Michelle , Atallah Waleed , Spitzer Matthew H. , Engleman Edgar , Mallick Parag 
Published: August 2020

AbstractBackgroundWhile technological advances have made it possible to profile the immune system at high resolution, translating high-throughput data into knowledge of immune mechanisms has been challenged by the complexity of the interactions underlying immune processes. Tools to explore the immune network are critical for better understanding the multi-layered processes that underlie immune function and dysfunction, but require a standardized network map of immune interactions. To facilitate this we have developed ImmunoGlobe, a manually curated intercellular immune interaction network extracted from Janeway’s Immunobiology textbook.ResultsImmunoGlobe is the first graphical representation of the immune interactome, and is comprised of 253 immune system components and 1112 unique immune interactions with detailed functional and characteristic annotations. Analysis of this network shows that it recapitulates known features of the human immune system and can be used uncover novel multi-step immune pathways, examine species-specific differences in immune processes, and predict the response of immune cells to stimuli. ImmunoGlobe is publicly available through a user-friendly interface atwww.immunoglobe.organd can be downloaded as a computable graph and network table.ConclusionWhile the fields of proteomics and genomics have long benefited from network analysis tools, no such tool yet exists for immunology. ImmunoGlobe provides a ground truth immune interaction network upon which such tools can be built. These tools will allow us to predict the outcome of complex immune interactions, providing mechanistic insight that allows us to precisely modulate immune responses in health and disease.