bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactobacillus rhamnosusattenuates bone loss and maintains bone health by skewing Tregs-Th17 cell balance in Ovx mice
Authors: Sapra Leena , Dar Hamid Y. , Pandey Amit , Kumari Surbhi , Azam Zaffar , Bhardwaj Asha , Shukla Prashant , Mishra Pradyumna K. , Verma Bhupendra , Srivastava Rupesh K. 
Published: August 2020

AbstractOsteoporosis is a systemic-skeletal disorder characterized by enhanced fragility of bones leading to increased rates of fractures and morbidity in large number of populations. Probiotics are known to be involved in management of various-inflammatory diseases including osteoporosis. But no study till date had delineated the immunomodulatory potential ofLactobacillus rhamnosus(LR) in bone-health. In the present study, we examine the effect of probiotic-LR on bone-health in osteoporotic (Ovx) mice model. We observed that administration of LR attenuated bone-loss in Ovx mice. Both the cortical and trabecular bone-content of LR treated group was significantly higher than Ovx-group. Remarkably, the percentage of osteoclastogenic-CD4+Rorγt+Th17 cells at distinct immunological sites such as BM, spleen, LN and PP were significantly reduced, whereas the percentage of anti-osteoclastogenic-CD4+Foxp3+Tregs and CD8+Foxp3+Tregs were significantly enhanced in LR-treated group thereby resulting in inhibition of bone-loss. The immunomodulatory-role of LR was further supported by serum-cytokine data with a significant reduction in proinflammatory-cytokines (IL-6, IL-17 and TNF-α) along with enhancement in anti-inflammatory-cytokines (IL-10, IFN-γ) in LR treated-group. Altogether, the present study for the first time establishes the osteoprotective role of LR on bone-health, thus highlighting the potential of LR in the treatment and management of various bone related diseases including osteoporosis.
Global population genomic analysis ofMycoplasma bovisisolates reveals transcontinental variations and potential virulence genes
Authors: Kumar Roshan , Register Karen , Christopher-Hennings Jane , Moroni Paolo , Gioa Gloria , Garcia-Fernandez Nuria , Nelson Julia , Jelinski Murray , Lysnyansky Inna , Bayles Darrell , Alt David , Scaria Joy 
Published: August 2020

AbstractAmong more than twenty species belonging to the class Mollecutes,Mycoplasma bovisis the most common cause of bovine mycoplasmosis in North America and Europe. Bovine mycoplasmosis causes significant economic loss in the cattle industry. The number ofM. bovispositive herds has recently increased in North America and Europe. Since antibiotic treatment is ineffective and no efficient vaccine is available,M. bovis-induced mycoplasmosis is primarily controlled by herd management measures such as the restriction of moving infected animals out of the herds and culling of infected animals or shedders. To better understand the population structure and genomic factors that may contribute to its transmission, we sequenced 147M. bovisstrains isolated from four different countries and hosts, primarily cattle. We performed a large-scale comparative analysis ofM. bovisgenomes by integrating 104 publicly available genomes and our dataset (251 total genomes). A whole genome-single nucleotide polymorphism (SNP)-based phylogeny revealed thatM. bovispopulation structure is composed of five clades with one of the isolates clustering with the outgroupM. agalactiae. These isolates were found to cluster with those from Canada, Israel, Lithuania, and Switzerland, suggesting trans-continental transmission of the strains. We also validated a previous report suggesting minimum divergence in isolates of Australian origin, which grouped within a single clade along with strains from China and Israel. However, no observable pattern of host association inM. bovisgenomes was found in this study. Our comparative genome analysis also revealed thatM. bovishas an open pangenome with a large breadth of unexplored diversity of genes. Analysis ofvspgene-host association revealed a singlevspsignificantly associated with bovine isolates that may be targeted for diagnostics or vaccine development. Our study also found thatM. bovisgenome harbors a large number of IS elements, including a novel 1624 bp IS element, and ISMbov9. Collectively, the genome data and the whole genome-based population analysis in this study may help to develop control measures to reduce the incidence ofM. bovis-induced mycoplasmosis in cattle and/or to identify candidate genes for vaccine development.
Characterization and structure of glyceraldehyde-3-phosphate dehydrogenase type 1 from Escherichia coli
Authors: Zhang L. , Liu M. R. , Yao Y. C. , Bostrom I. K. , Wang Y. D. , Chen A. Q. , Li J. X. , Gu S. H. , Ji C. N. 
Published: August 2020

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic pathway that catalyzes the conversion of D-glyceraldehyde 3-phosphate to 1,3-diphosphoglycerate. Here, the full-length GAPDH type 1 from Escherichia coli (EcGAPDH1) was cloned and overexpressed, and the protein was purified. Biochemical analyses found that the optimum reaction temperature and pH of EcGAPDH1 were 55°C and 10.0, respectively. The protein has a certain amount of thermostability. Crystals of EcGAPDH1 were obtained using the sitting-drop vapor-diffusion technique and X-ray diffraction data were collected to 1.88 Å resolution. Characterization of the crystals showed that they belonged to space group P41212, with unit-cell parameters a = b = 89.651, c = 341.007 Å, α = β = γ = 90°. The structure of EcGAPDH1 contains four subunits, each of which includes an N-terminal NAD+-binding domain and a C-terminal catalytic domain. Analysis of the NAD+-bound form showed some differences between the structures of EcGAPDH1 and human GAPDH. As EcGAPDH1 shares 100% identity with GAPDH from Shigella sonnei, its structure may help in finding a drug for the treatment of shigellosis.
Venture capital network and the M&A performance of listed companies
Authors: Jin Yonghong , Xu Meng , Wang Wei , Xi Yuqin 
Published: August 2020

PurposeThe purpose of this paper is to discuss how venture capital institutions can use their syndicated investment network to help listed companies to achieve better performance in mergers and acquisitions (M&A) activities.Design/methodology/approachThis paper builds a fixed effect unbalanced panel regression model to study the impact of venture capital network on the M&A performance of listed companies.FindingsEvidence indicated that the stronger the information resource acquisition ability of venture capital institutions in the network, the better the listed company's M&A performance supported; the stronger the information resource control ability of venture capital institutions in the network, the better the listed company's M&A performance supported; the higher the participation of venture capital institutions, the more significant the positive impact of information resource acquisition and information resource control abilities on M&A performance in the network.Research limitations/implicationsThe data in this paper are from China's Growth Enterprise Market (GEM), other markets may be considered in the future research studies.Practical implicationsThe research conclusions of this paper affirm the positive role played by venture capital institutions through syndicated investment in eliminating information asymmetry in M&A of invested companies. The information resource acquisition and control abilities and participation degree of the venture capital network have positively promoted the M&A performance of the invested enterprises.Originality/valueThe conclusions of this paper not only provide useful supplements to existing research literature on venture capital network functions and corporate M&A but also have certain guiding value for venture capital institutions and start-ups to better use venture capital practices to improve their capabilities and performance.
Examining strategies behind universities’ technology transfer portfolio: how different patterns of resource consumption can lead to similar technology transfer profiles
Authors: Berbegal-Mirabent Jasmina , Gil-Doménech Dolors , de la Torre Eva M. 
Published: August 2020

PurposeThe purpose of this study is to analyse how different patterns of production factors consumption of Spanish universities lead to specific technology transfer (TT) profiles (outcomes).Design/methodology/approachAdopting a resource-based view perspective (RBV), qualitative comparative analysis (QCA) is used to analyse the relationship between different combinations of resources – human resources, financial resources and support services – and various portfolios of TT outcomes – intellectual or industrial property agreements, spin-offs and TT income.FindingsResults indicate that there is no unique formula of resource consumption that leads to a specific portfolio of TT outcomes. These results seem to reflect the characteristics and competencies added by universities, along with the characteristics of their socioeconomic context. From a RVB perspective, this indicates that the considered resources are substitutable.Practical implicationsThe effectiveness of university policies is expected to vary by university, for example depending on the type of resources that is most relevant in the university’s production process. To develop competitive advantages Spanish public universities must resort to internal intangible resources or specific and inimitable combinations of the available resources.Social implicationsSince Spanish universities are heterogeneous and display different TT portfolios they address the needs of different users.Originality/valuePrevious studies have failed to acknowledge the heterogeneity among universities. To perform the analysis QCA is used, an innovative methodology in the higher education sector that enables us to purposefully acknowledge institutional diversity (in both resources and results). This allows us to indirectly take into account the capabilities of universities using a more holistic approach to evaluate their competitiveness.
From green buildings to living buildings? Rating schemes and waste management practices in Australian educational buildings
Authors: Udawatta Nilupa , Zuo Jian , Chiveralls Keri , Zillante George 
Published: August 2020

PurposeThere is an increasing level of recognition of the pressing issues associated with climate change and resource depletion. As a result, it is well recognised that higher education institutions bear responsibilities to promote “sustainable development”. Many universities have adopted green building practices in the construction of their building infrastructure. A variety of Green Building Rating Tools (GBRTs) have been designed to facilitate green building developments. Thus, the aim of this research is to identify mechanisms to improve current GBRTs in terms of waste management (WM) practices by using green star accredited educational buildings in Australia.Design/methodology/approachA qualitative approach was adopted in this study to achieve the research aim by conducting three case studies of educational buildings in South Australia. Thirty three interviews were carried out in a face-to-face, semi-structured manner and project documentations were reviewed. The participants were asked to provide their expert opinions on the GS initiative and its ability to minimise waste generation, the impact of the GS initiative on solid WM practices and problems associated with the implementation process of the GS initiative. Data was analysed using code-based content analysis using the NVivo software package. Tables and figures were used as the visualization technique to present an expedient understanding in a holistic manner.FindingsFindings showed that the Green Star (GS) initiative drives change in the way current practices are performed in the Australian construction industry. However, this study revealed that WM targets outlined in the GS initiative are not challenging enough. Thus, suggestions are provided in this research to improve the WM aspects of GS initiatives by looking beyond a focus on “sustainability” and “waste minimisation” towards a focus on regenerative environments.Originality/valueThese findings are valuable for practitioners and policymakers seeking to improve WM practices and to address issues associated with climate change and resource depletion.
Sunscreen use: a theory-based interventional study using HAPA
Authors: Panahi Hadiseh , Keikavoosi-Arani Leila , Salehi Leili 
Published: August 2020

PurposeThe current study was aimed to assess health action process approach (HAPA) effectiveness in sunscreen using among paddy workersDesign/methodology/approachThis interventional study was conducted on 177 paddy workers from Rudsar city. The subjects were randomly assigned into motivational, volitional and control groups. The motivational and volitional groups received the educational intervention based on HAPA. Three groups were evaluated in terms of HAPA constructs, intention and behavior at three times before the intervention, immediately afterward and one month later. Chi-square, repeated measure test were used to analyze the data using SPSS software version 19.FindingsThe mean age was 47.78 ± 12.66. The majority of the participants were female (69.3%) and had diploma. based on repeated measure test results the score of the use of sunscreen during the time in intervention groups as well as between the three groups were changed. Based on the results of this study, the score of the constructs of both phases of HAPA in the two groups (motivational and volitional) compared to control group was significantly improved (p < 0.05).Practical implicationsThe study shows the use of HAPA for the behavioral change related to sunscreen use among the paddy workers as the high-risk group.Originality/valueNorth of Iran
Identifying key quality features for wearable technology embedded products using the Kano model
Authors: Salahuddin Mir , Lee Young-A 
Published: August 2020

PurposeThe purpose of this study was to identify the major quality features of wearable technology embedded products that have the greatest impact on consumer satisfaction using the Kano model, an organized approach to specify consumer requirements and expectation through a preference classification technique.Design/methodology/approachUsing a quantitative research method, an online survey was conducted with a convenience sample of US consumers aged between 19 years old and over. A total of otal 471 useable data were obtained and used for the data analysis.FindingsThis study identified that the 11 quality features of wearables belong to one-dimensional quality category among the five Kano categories, although the impact of each quality feature's performance on consumer satisfaction varies. The results also showed that the performance level of durability, long battery life, usability, product safety, comfortability and reasonable price has the greatest impact on consumer satisfaction of wearables.Research limitations/implicationsThis study has implications for future research by integrating the Kano model with other design and product development related theoretical models when designing, developing and evaluating various wearable products.Originality/valueThis study quantified the key quality features of wearables using the Kano model, which can be a great measurement tool for future researchers to adopt in their studies. The findings of this study help designers, developers and producers of wearables to prioritize the quality features during the product design, development and manufacturing process.
Moderating effect of optimum stimulation level on the relationship between satisfaction and revisit intention: the case of Turkish cultural tourists
Authors: Evren Savaş , Şimşek Evren Emine , Çakıcı A. Celil 
Published: August 2020

Purpose
The purpose of this study is to determine the optimum stimulation levels (OSLs) of cultural tourists within the context of their novelty seeking tendencies and to determine whether their OSLs have a moderating effect on the relationship between their satisfaction and revisit intentions.

Design/methodology/approach
To collect data, an online survey was conducted for Turkish cultural tourists (n = 563) in May 2018, and the data were analysed with PROCESS by Hayes.

Findings
The study’s findings demonstrated that Turkish cultural tourists were high-level novelty seekers and that novelty seeking has a moderating effect on the relationship between their satisfaction and short-term revisit intentions.

Originality/value
This study contributes to the literature by revealing the moderator effect of novelty seeking tendency on the relationship between satisfaction and revisit intention within the scope of cultural tourism, which has not been examined before.
The politics behind design projects: when space, organization, and technology collide
Authors: Jemine Grégory , Pichault François , Dubois Christophe 
Published: August 2020

PurposeWhile more and more organizations commit to transformation projects with the aim of redesigning simultaneously their workspaces, work organization, and technologies, the design process supporting such projects remains largely understudied. This paper examines the political tensions that occur when such processes unfold as well as their implications for project management. By doing so, the paper counterbalances the prescriptive and normative literature on “New Ways of Working” which largely overlooks the political complexity of such projects.Design/methodology/approachThe paper is based on a qualitative study of a triple design process in a media company. Data collection mainly consists of a nine-month process of non-participant observation of weekly meetings held by the strategic group in charge of the project. Semi-structured interviews with members of the executive committee have also been conducted.FindingsThe analysis illustrates how space, organization and technology are gradually designed and structured. Four interconnected and often concealed mechanisms that support triple design processes are identified: political tensions, unexpected twists, conflicting temporalities and arbitration measures.Originality/valueThe originality of the paper lies in breaking down the concept of design in three separate objects – organization, space and technology – and examining how these objects were conjointly problematized by an organization in transformation, whereas existing studies often investigate organization design, space design or technology design in isolation.
New product development process in apparel industry using Industry 4.0 technologies
Authors: Wijewardhana Ganguli Eranga Harshamali , Weerabahu Samanthi Kumari , Nanayakkara Julian Liyanage Don , Samaranayake Premaratne 
Published: August 2020

PurposeThe main purpose of this paper is to assess the technological view of apparel new product development (NPD) process through a framework for improving the efficiency of NPD process in Sri Lankan apparel industry.Design/methodology/approachThe study uses literature review, a survey and in-depth interviews of industry experts for data collection. Descriptive analysis and correlation analysis are used to identify the relationship between NPD process performance and Industry 4.0 (I4) technology components.FindingsAll technology components are enablers of NPD process, yet the relative importance of technology components varies within the NPD life cycle. Technoware is identified as the most significant, while Humanware component is the least significant for the advancement of I4 technologies in the NPD process.Research limitations/implicationsDespite the novelty of research investigation into NPD process using I4 technologies in apparel industry, it is limited to one geographical location and a small segment of the industry.Practical implicationsThis paper assists apparel industry practitioners to better understand and prioritize I4 technology components in the NPD life cycle for their successful adoption and for reaping the benefits.Originality/valueThis research generates new knowledge on the adoption of I4 technologies using industry insights into technology components mapped/aligned with key stages of NPD life cycle.
What influences patients' willingness to choose in online health consultation? An empirical study with PLS–SEM
Authors: Wan Yan , Zhang Yifan , Yan Mengling 
Published: August 2020

PurposeOnline trust is a key factor for successful online transactions. To some extent, online health consultation can be considered an online transaction. Owing to the unique physician–patient relationship, patients' choice of physicians within an online health consultation setting may not only be based on rational judgments but also considerably affected by their feelings. Hence, the purpose of this study was to explore which physicians' attributes affect patients' cognitive and affective trust in physicians, as well as how these two variables and their association affect patients' willingness to choose.Design/methodology/approachBased on the broad conceptual framework of online trust, this paper proposed a set of hypotheses that were tested through analyzing survey data using structural equation modeling techniques.FindingsResults showed that physicians' ability had a significant positive influence on patients' cognitive trust in the physician; physicians' integrity and benevolence had a significant positive influence on patients' affective trust in the physician; cognitive and affective trust had a significant positive impact on patients' willingness to choose and there were significant positive interactions between affective and cognitive trust.Originality/valueThis study theoretically enriches the generic model of online trust. From the practical perspective, it will provide physicians working in online health consultation platforms and relevant practitioners with baseline information on the topic and advice for decision-making toward service enhancement and clientele improvements.
Do value cocreation and engagement drive brand evangelism?
Authors: Harrigan Paul , Roy Sanjit K. , Chen Tom 
Published: August 2020

PurposeDrawing on service logic, the authors investigate how value cocreation leads to evangelical brand-related behaviors (brand defense and brand advocacy). The authors analyze the interplay between value cocreation and customer brand engagement on social media in driving these outcomes. The authors also consider the role of brand love in eliciting evangelical brand-related behaviors.Design/methodology/approachRespondents recruited through Amazon MTurk were surveyed on social media use in tourism-related decisions. The total useable sample size was 397. Partial least squares structural equation modeling (PLS-SEM) was used to test the research model.FindingsValue cocreation and customer brand engagement are drivers of evangelical brand-related behaviors, emphasizing the importance of these two in marketing and how they drive behavioral outcomes.Research limitations/implicationsService logic highlights the significance of value cocreation which, through customer brand engagement and love, leads to brand defense and advocacy. This explains the mediation in our model, where marketers must undertake efforts to support customer brand engagement and brand love.Practical implicationsValue is created by the user for the user through their experiences over time. Brands are owned by customers, and their defense and advocacy of them must be earned. Marketers facilitate customer value creation by providing the resources to cocreate value and love the brand.Originality/valueMost studies investigate value cocreation from an in-role and/or extra-role perspective as to how it benefits firms. Through service logic, the authors illustrate how it leads to evangelical brand-related behaviors.