bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detectability of 21-cm signal during the epoch of reionization with 21-cm-Lyman-α emitter cross-correlation – III. Model dependence
Authors: Kubota Kenji , Inoue Akio K , Hasegawa Kenji , Takahashi Keitaro 
Published: April 2020

ABSTRACT
Detecting H i 21-cm line in the intergalactic medium during the epoch of reionization suffers from foreground contamination such as Galactic synchrotron and extragalactic radio sources. Cross-correlation between the 21-cm line and Lyman-α emitter (LAE) galaxies is a powerful tool to identify the 21-cm signal since the 21-cm line emission has correlation with LAEs, while the LAEs are statistically independent of the foregrounds. So far, the detectability of 21-cm-LAE cross-power spectrum has been investigated with simple LAE models where the observed Lyα luminosity is proportional to the dark matter halo mass. However, the previous models were inconsistent with the latest observational data of LAEs obtained with Subaru/Hyper Suprime-Cam (HSC). Here, we revisit the detectability of 21-cm-LAE cross-power spectrum adopting a state-of-the-art LAE model consistent with all Subaru/HSC observations such as the Lyα luminosity function, LAE angular autocorrelation, and the LAE fractions in the continuum selected galaxies. We find that resultant cross-power spectrum with the updated LAE model is reduced at small scales ($k\sim 1\ \rm Mpc^{-1}$) compared to the simple models, while the amplitudes at large scales ($k \lesssim 0.2 \ \rm Mpc^{-1}$) are not affected so much. We conclude that the large-scale signal would be detectable with Square Kilometre Array (SKA) and HSC LAE cross-correlation but detecting the small-scale signal would require an extended HSC LAE survey with an area of $\sim 75\ \rm deg^2$ or 3000 h observation time of 21-cm line with SKA.
PSR J1012+5307: a millisecond pulsar with an extremely low-mass white dwarf companion
Authors: Mata Sánchez D , Istrate A G , van Kerkwijk M H , Breton R P , Kaplan D L 
Published: April 2020

ABSTRACT
Binaries harbouring millisecond pulsars (MSPs) enable a unique path to determine neutron star (NS) masses: radio pulsations reveal the motion of the NS, while that of the companion can be characterized through studies in the optical range. PSR J1012+5307 is an MSP in a 14.5-h orbit with a helium-core white dwarf (WD) companion. In this work we present the analysis of an optical spectroscopic campaign, where the companion star absorption features reveal one of the lightest known WDs. We determine a WD radial velocity semi-amplitude of $K_2 = 218.9 \pm 2.2\, \rm km\, s^{-1}$, which combined with that of the pulsar derived from the precise radio timing, yields a mass ratio of q = 10.44 ± 0.11. We also attempt to infer the WD mass from observational constraints using new binary evolution models for extremely low-mass (ELM) WDs, but find that they cannot reproduce all observed parameters simultaneously. In particular, we cannot reconcile the radius predicted from binary evolution with the measurement from the photometric analysis ($R_{\rm WD}=0.047_{-0.002}^{+0.003}\, \mathrm{ R}_{\odot }$). Our limited understanding of ELM WD evolution, which results from binary interaction, therefore comes as the main factor limiting the precision with which we can measure the mass of the WD in this system. Our conservative WD mass estimate of $M_{\rm WD} = 0.165 \pm 0.015\, \mathrm{ M}_{\rm \odot }$, along with the mass ratio enables us to infer a pulsar mass of $M_{\rm NS} = 1.72 \pm 0.16\, \mathrm{ M}_{\rm \odot }$. This value is clearly above the canonical $\sim 1.4\, \mathrm{ M}_{\rm \odot }$, therefore adding PSR J1012+5307 to the growing list of massive MSPs.
TFmotifView: a webserver for the visualization of transcription factor motifs in genomic regions
Authors: Leporcq Clémentine , Spill Yannick , Balaramane Delphine , Toussaint Christophe , Weber Michaël , Bardet Anaïs Flore 
Published: April 2020

AbstractTranscription factors (TFs) regulate the expression of gene expression. The binding specificities of many TFs have been deciphered and summarized as position-weight matrices, also called TF motifs. Despite the availability of hundreds of known TF motifs in databases, it remains non-trivial to quickly query and visualize the enrichment of known TF motifs in genomic regions of interest. Towards this goal, we developed TFmotifView, a web server that allows to study the distribution of known TF motifs in genomic regions. Based on input genomic regions and selected TF motifs, TFmotifView performs an overlap of the genomic regions with TF motif occurrences identified using a dynamic P-value threshold. TFmotifView generates three different outputs: (i) an enrichment table and scatterplot calculating the significance of TF motif occurrences in genomic regions compared to control regions, (ii) a genomic view of the organisation of TF motifs in each genomic region and (iii) a metaplot summarizing the position of TF motifs relative to the center of the regions. TFmotifView will contribute to the integration of TF motif information with a wide range of genomic datasets towards the goal to better understand the regulation of gene expression by transcription factors. TFmotifView is freely available at http://bardet.u-strasbg.fr/tfmotifview/.
Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
Authors: Verheyen Toon , Fang Trixy , Lindenhofer Dominik , Wang Yang , Akopyan Karen , Lindqvist Arne , Högberg Björn , Teixeira Ana I 
Published: April 2020

Abstract
Ligand binding induces extensive spatial reorganization and clustering of the EphA2 receptor at the cell membrane. It has previously been shown that the nanoscale spatial distribution of ligands modulates EphA2 receptor reorganization, activation and the invasive properties of cancer cells. However, intracellular signaling downstream of EphA2 receptor activation by nanoscale spatially distributed ligands has not been elucidated. Here, we used DNA origami nanostructures to control the positions of ephrin-A5 ligands at the nanoscale and investigated EphA2 activation and transcriptional responses following ligand binding. Using RNA-seq, we determined the transcriptional profiles of human glioblastoma cells treated with DNA nanocalipers presenting a single ephrin-A5 dimer or two dimers spaced 14, 40 or 100 nm apart. These cells displayed divergent transcriptional responses to the differing ephrin-A5 nano-organization. Specifically, ephrin-A5 dimers spaced 40 or 100 nm apart showed the highest levels of differential expressed genes compared to treatment with nanocalipers that do not present ephrin-A5. These findings show that the nanoscale organization of ephrin-A5 modulates transcriptional responses to EphA2 activation.
Chloroquine and hydroxychloroquine for the treatment of COVID-19: A living systematic review protocol
Authors: Bravo-Jeria Rocío , Rojas Reyes María Ximena , Ariel Franco Juan Víctor , Acuña María Paz , Torres López Luz Ángela , Rada Gabriel ,   COVID-19 L·OVE Working Group
Published: April 2020

ABSTRACTObjectiveTo determine the relative impact of the use of chloroquine and hydroxychloroquine on outcomes important to patients with COVID 19.DesignThis is the protocol of a living systematic review.Data sourcesWe will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), trial registries, grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal.Eligibility criteria for selecting studies and methodsWe will follow a common protocol for multiple parallel systematic reviews, already published and submitted to PROSPERO (awaiting ID allocation).We will include randomised controlled trials evaluating the effect of chloroquine and hydroxychloroquine — as monotherapy or in combination with other drugs — versus placebo or no treatment in patients with COVID-19. Randomised trials evaluating chloroquine and hydroxychloroquine in infections caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes.Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome.A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.Ethics and disseminationNo ethics approval is considered necessary. The results of this review will be widely disseminated via peer-reviewed publications, social networks and traditional media.
Functional Connectivity based Brain Signatures of Behavioral Regulation in Children with ADHD, DCD and ADHD-DCD
Authors: Rohr Christiane S. , Bray Signe , Dewey Deborah 
Published: April 2020

ABSTRACTBackgroundChildren with neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD) often struggle with behavioral self-regulation (BR), which is associated with daily-life challenges. ADHD sometimes presents with Developmental Coordination Disorder (DCD), but little is known about BR in DCD. BR is thought to involve limbic, prefrontal, parietal and temporal brain areas. Given the risk for negative outcomes, gaining a better understanding of the brain mechanisms underlying BR in children with ADHD and/or DCD is imperative.MethodsResting-state fMRI data collected from 115 children (31 typically developing (TD), 35 ADHD, 21 DCD, 28 ADHD-DCD) aged 7-17 years were preprocessed and motion was mitigated using ICA-AROMA. Emotion control, inhibition, and shifting were assessed as subdomains of BR. Functional connectivity (FC) maps were computed for ten limbic, prefrontal, parietal and temporal regions of interest and were investigated for associations with BR subdomains across all participants as well as for significant group differences.ResultsMultiple FC patterns were associated with BR across all participants. Some FC patterns were associated with multiple BR subdomains, while others were associated with only one. Differences in BR were found only between children with ADHD (i.e. ADHD and ADHD-DCD) and those without ADHD (i.e. TD and DCD). FC differences were also found between children with and without ADHD.ConclusionsOur results show dimensional associations between BR subdomain scores and whole-brain FC and highlight the potential of these associative patterns as brain-based signatures of BR in children with and without ADHD.
Proximity-based proteomics reveals the thylakoid lumen proteome in the cyanobacteriumSynechococcussp. PCC 7002
Authors: Dahlgren Kelsey K. , Gates Colin , Lee Thomas , Cameron Jeffrey C. 
Published: April 2020

AbstractCyanobacteria possess unique intracellular organization. Many proteomic studies have examined different features of cyanobacteria to learn about the structure-function relationships between the intracellular structures of cyanobacteria and their roles in cells. While these studies have made great progress in understanding cyanobacterial physiology, the previous fractionation methods used to purify cellular structures have limitations; specifically, certain regions of cells cannot be purified with existing fractionation methods. Proximity-based proteomics techniques were developed to overcome the limitations of biochemical fractionation for proteomics. Proximity-based proteomics relies on spatiotemporal protein labeling followed by mass spectrometry of the labeled proteins to determine the proteome of the region of interest. We have performed proximity-based proteomics in the cyanobacteriumSynechococcus sp.PCC 7002 with the APEX2 enzyme, an engineered ascorbate peroxidase. We determined the proteome of the thylakoid lumen, a region of the cell that has remained challenging to study with existing methods, using a PsbU-APEX2 gene fusion. This study demonstrates the power of APEX2 as a tool to study the cell biology of intracellular features of cyanobacteria with enhanced spatiotemporal resolution.
Anthropometric measurements in children with ASD point to genomic imprinting imbalance
Authors: Niculae Alexandru-Ștefan 
Published: April 2020

ABSTRACTAutism Spectrum Disorder (ASD) is a large set of neurodevelopmental disorders of complex aetiology. A mix of genetic and environmental factors are likely to cause ASD. Genetic risk for autism comes from common genetic variation.Genomic imprinting refers to genes that have different expression patterns according to the parent of origin – being silenced when imprinted. Paternally active genes increase resource extraction from the mother and reduce resource burden on the father.Children with ASD show consistent overgrowth during their first 1-2 years of life. Recently, it has been shown that children with higher birth weight and length have an increased risk of developing ASD. This overgrowth and apparent larger birth weight and length are consistent with the notion that a paternally biased genome might underlie the risk for ASD.The study compared height, weight, head circumference and thoracic circumference for age-matched (ages 4-8 years old) male children with ASD (n=30) with neurotypical children (n=33).No clinically significant differences were found among the two groups.After weaning, relative paternal contribution to a child’s somatic development would increase, thus one would expect paternally active genes to start changing the child’s behaviour, so as to make the child less demanding of resources (overall, and thus also on the father), with a counterweight represented by maternally active genes. A relative overabundance of paternally active genes would explain the data presented here, that shows children with ASD being no different from controls. Given the fact presented by other studies, that children with ASD seem to get a head start in growth, the lack of differences found in this 4-8 years old group indicates that children with ASD might actually fall behind in somatic growth, or at least stagnate by middle childhood.
Movement history influences pendulum test kinematics in children with spastic cerebral palsy
Authors: Jente Willaert , Desloovere Kaat , Van Campenhout Anja , Ting Lena H. , De Groote Friedl 
Published: April 2020

AbstractThe pendulum test assesses quadriceps spasticity by dropping the lower leg of a relaxed patient from the horizontal position and observing limb movement. The first swing excursion decreases with increasing spasticity severity. Our recent simulation study suggests that the reduced initial swing results from muscle short-range stiffness and its interaction with reflex hyper-excitability. Short-range stiffness emerges from the thixotropic behavior of muscles where fiber stiffness upon stretch increases when the muscle is held isometric. Fiber stiffness might thus be higher during the first swing of the pendulum test than during consecutive swings. In addition, it has recently been suggested that muscle spindle firing reflects fiber force rather than velocity and therefore, reflex activity might depend on fiber stiffness. If this hypothesized mechanism is true, we expect to observe larger first swing excursions and reduced reflex muscle activity when the leg is moved rather than kept isometric before release, especially in patients with increased reflex activity. We performed the pendulum test in 15 children with cerebral palsy (CP) and 15 age-matched typically developing (TD) children in two conditions. In the hold condition, the leg was kept isometric in the extended position before release. In the movement condition, the leg was moved up and down before release to reduce the contribution of short-range stiffness. Knee kinematics and muscle activity were recorded. Moving the leg before release increased first swing excursion (p < 0.001) and this increase was larger in children with CP (21°) than in TD children (8°) (p < 0.005). In addition, pre-movement delayed reflex onset by 87 ms (p < 0.05) and reduced reflex activity as assessed through the area under the curve of rectus femoris electromyography (p < 0.05) in children with CP. The movement history dependence of pendulum kinematics and reflex activity supports our hypothesis that muscle short-range stiffness and its interaction with reflex hyper-excitability contribute to joint hyper-resistance in spastic CP. Our results have implications for standardizing movement history in clinical tests of spasticity and for understanding the role of spasticity in functional movements, where movement history differs from movement history in clinical tests.
Corporate governance and value relevance of accounting information
Authors: Almujamed Hesham I. , Alfraih Mishari M. 
Published: April 2020

Purpose
This paper aims to explore how the characteristics of the board of directors (BoD) shape earnings and book value information available to market participants.

Design/methodology/approach
The authors investigated the impact of board size, presence of non-executives and role duality as proxies of effective corporate governance on the value relevance of financial reporting for 178 firms on the Kuwait stock exchange in 2013. Regression analysis based on Ohlson’s (1995) valuation model was used to test hypotheses.

Findings
The authors found that board size was significantly associated with company value and that Kuwaiti firms with large boards increased the value-relevance of earnings and book value. The influence of role duality was positive although not significant. The presence of non-executives on the board had a negative correlation with market value (not significant).

Research limitations/implications
These findings deliver empirical support for the prediction that the characteristics of the BoD improve the value relevance of financial reporting. Limitations such as small sample size and one-year duration of the study did not negate the basic findings, however. Future studies will use larger samples, longer duration and additional board characteristics.

Practical implications
This study provides empirical support for the hypothesis that board size influences market valuation. This study may benefit managers, investors and other decision-makers.

Originality/value
This study delivers empirical evidence on the impact of board characteristics on the value relevance of accounting information. It will be useful for regulators and market participants monitoring the influence of board characteristics on the value relevance of accounting information.
Facebook as a follow-up tool for women with criminal justice histories
Authors: Lipnicky Ashlyn , Kelly Patricia J. , Ramaswamy Megha 
Published: April 2020

Purpose
The purpose of this study is to measure Facebook (FB) use as a tool for maintaining research contact with hard-to-reach women with criminal justice histories.

Design/methodology/approach
Retrospective data were analyzed from a jail health intervention. Bivariate analysis compared the rates of follow-up between FB group users and non-FB group users at one post-intervention time point. Multivariate models explored predictors for FB group follow-up.

Findings
Among 184 participants, 89 (48.4%) used the private research FB group. This group was more likely to complete the follow-up survey one year after enrollment compared to non-FB group users (P = 0.002). Regression analyses showed that, compared to non-FB group users, FB group users were more likely to be younger and have a history of sexually transmitted infections.

Practical implications
FB is popular among women with criminal justice histories. Use of this social media site with study participants from hard-to-reach populations may enhance study retention.

Originality/value
This paper fills a gap in examining the long-term use of FB as a research strategy to maintain contain with typically hard-to-reach populations.
Individuals' intention to use sports wearables: the moderating role of technophobia
Authors: Cavdar Aksoy Nilsah , Kocak Alan Alev , Tumer Kabadayi Ebru , Aksoy Alican 
Published: April 2020

PurposeThis study aims to examine the wearable devices market as an essential representative of the digital age using a framework based on the Unified Theory of Acceptance and Use of Technology (UTAUT) and the context of sports wearables.Design/methodology/approach411 people, are both users and non-users of this technology were surveyed online, and the obtained data analyzed using structural equation modeling.FindingsThe results support the effects of performance expectancy, effort expectancy, facilitating conditions, and social influence on attitude toward sports wearables and attitude of usage intention. Further, technophobia moderates the relationship between performance expectancy and attitude. However, a moderating effect of technophobia on the relationship between effort expectancy and attitude was not observed.Originality/valueDue to innovative technologies in the digital age we live in, the devices we use in everyday life have gained intelligence. As more developments take place, and related products enter the market, understanding how people react to these products becomes an important issue. While investigating this issue in the context of sports wearables in this study, an important psychological construct, technophobia, was included in the research model in order to explore the usage intention of individuals through the effects of psychological constructs, such as paranoia, fear, anxiety, cybernetic revolt and cellphone avoidance, and the strong combination of important constructs of phobia to go against technology.
Price and its forecasting of Chinese cross-border E-commerce
Authors: Chen Jianping , Tournois Nadine , Fu Qiming 
Published: April 2020

Purpose
Cross-border e-commerce in China has been booming in recent years. This paper aims to study pricing in Chinese cross-border e-commerce companies and focuses on the baby food market, which is simply examined as a case study to highlight broader implications. In this intensely competitive sector, the biggest challenge faced by such companies is ensuring that they are in a position to be able set prices in the short-term to maximize their competitive advantage and profitability. The study of pricing will help management to make correct operational decisions.

Design/methodology/approach
This study utilizes transaction data, which were obtained from the Taobao e-commerce platform. Taobao is the largest e-commerce retail platform in the world. We analyzed factors, including business models, homogeneity, reputation ratings and sales volumes, which may affect pricing.

Findings
This study found that consumers in the baby food sector of Chinese cross-border e-commerce are not price-sensitive. Consumers are reputation-rating-sensitive. The reputation ratings of sellers affect the price dispersion in e-commerce markets. The Core Price Dispersion Rate Model not only considers the prices but also takes sales volumes into account in the calculations. Finally, based on Gaussian processes, a model was developed for price forecasting in the area of cross-border e-commerce. The experimental results show that the proposed method is highly valuable for price forecasting.

Originality/value
This study provides a novel understanding of the baby food sector in the Chinese cross-border e-commerce market by examining the business model, price dispersion, reputation rating and correlation between the reputation of sellers, prices and sales volume. Furthermore, a model for price forecasting is proposed.