bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotype scores in energy and iron-metabolising genes are higher in elite endurance athletes than in nonathlete controls
Authors: Varillas Delgado David , Tellería Orriols Juan José , Monge Martín Diana , Del Coso Juan 
Published: May 2020

Information about the association of energy and iron-metabolising genes with endurance performance is scarce. The objective of this investigation was to compare the frequencies of polymorphic variations of genes involved in energy generation and iron metabolism in elite endurance athletes versus nonathlete controls. Genotype frequencies in 123 male elite endurance athletes (75 professional road cyclists and 48 elite endurance runners) and 122 male nonathlete participants were compared by assessing 4 genetic polymorphisms: AMPD1 c.34C/T (rs17602729), PPARGC1A c.1444G/A (rs8192678) HFEH63D c.187C/G (rs1799945) and HFEC282Y c.845G/A (rs1800562). A weighted genotype score (w-TGS; from 0 to 100 arbitrary units (a.u.)) was calculated by assigning a corresponding weight to each polymorphism. In the nonathlete population, the mean w-TGS value was lower (39.962 ± 14.654 a.u.) than in the group of elite endurance athletes (53.344 ± 17.053 a.u). The binary logistic regression analysis showed that participants with a w-TGS > 38.975 a.u had an odds ratio of 1.481 (95% confidence interval: 1.244–1.762; p < 0.001) for achieving elite athlete status. The genotypic distribution of polymorphic variations involved in energy generation and iron metabolism was different in elite endurance athletes vs. controls. Thus, an optimal genetic profile in these genes might contribute to physical endurance in athlete status. Novelty Genetic profile in energy generation and iron-metabolising genes in elite endurance athletes is different than that of nonathletes. There is an implication of an “optimal” genetic profile in the selected genes favouring endurance sporting performance.
NAO-Teach: helping kids to learn societal and theoretical knowledge with friendly human-robot interaction
Authors: Basori Ahmad Hoirul 
Published: May 2020

<span lang="EN-GB">Robotic technology has affected the education field, and even early education involves robot to attract Kids. Technical education is the notion of giving students knowledge of robots and technology. The main contribution of our research is to provide an interactive way of learning for kids through play and fun method. Two approaches proposed here: first, we provide an interactive game by touching robots body parts to teach kids how they were practising their motoric nerve and the listening to the instruction. In this game, kids asked to find some robot parts such as right hand, or left hand, where it equipped with a tactile sensor. The game difficulty can be increased by setting up the time limit for the answer and make kids touch the body parts of the robot very fast. The second learning method is practising number counting and pronunciation with NAO Robots. The robots will do computer vision processing to analyse and pronounce the kids handwriting with an artificial neural network. The result of implementation has obtained more than 75% success rate on recognition part with loss es than 0.6. The system received strong appreciation from kids and their parent, while This research believed able to attract kids to study in interactive and fun ways.</span>
PV system reactive power coordination with ULTC & shunt capacitors using grey wolf optimizer algorithm
Authors: Sankaraiah Mogaligunta , Suresh Reddy S , Vijaya Kumar M 
Published: May 2020

The presence of PV systems increases rapidly in distribution systems to improve reliability and quality of supply. This will influence the performance of under load tap changing (ULTC) transformer and related reactive power devices. Therefore, many researchers are working on this area. This paper main objective is to reduce switching operations of reactive power devices (ULTC and Shunt capacitors) together with system power loss. Distribution system load and solar system power will predict one day in advance and grey wolf optimizer (GWO) algorithm proposed to solve the objective function. Reactive power of solar system is coordinated together with ULTC and shunt capacitors (SCs) with the aid of forecasted load. Distribution system losses and switching operations of ULTC and SCs converted into objective function in terms of cost. The proposed method is applied on practical 10KV system and the results are compared with conventional and particle swarm optimization (PSO) methods considering grid conditions.
An immune memory and negative selection to visualizing clinical pathways from electronic health record data
Authors: Berquedich Mouna , Kamach Oulaid , Masmoudi Malek , Deshayes Laurent 
Published: May 2020

Clinical pathways indicate the applicable treatment order of interventions. In this paper we propose a data-driven methodology to extract common clinical pathways from patient-centric Electronic Health Record data (EHR). The analysis of patient's, can lead to better regarding pathologies. The proposed algorithmic methodology consist to designing a system of control and analysis of patient records based on an analogy between the elements of the new EHRs and the biological immune systems. The detection of patient profiles ensured by biclustering Matrix. We rely on biological immunity to develop a set of models for structuring knowledge extracted from EHR and to make pathway analysis decisions. A specific analysis of the functional data leds to the detection of several types of patients who share the same EHR information. This methodology demonstrates its ability to simultaneously processing data, and is able to providing information for understanding and identifying the path of patients as well as predicting the path of future patients.
DA systematic approach for solving mixed constraint fuzzy balanced and unbalanced transportation problem
Authors: Hamoud Ahmed , Ghadle Kirtiwant , Pathade Priyanka 
Published: May 2020

<p>In the present article, a mixed type transportation problem is considered. Most of the transportation problems in real life situation have mixed type transportation problem this type of transportation problem cannot be solved by usual methods. Here we attempt a new concept of Best Candidate Method (BCM) to obtain the optimal solution. To determine the compromise solution of balanced mixed fuzzy transportation problem and unbalanced mixed fuzzy transportation problem of trapezoidal and trivial fuzzy numbers with new BCM solution procedure has been applied. The method is illustrated by the numerical examples.</p>
Intramuscular venous malformations of the calf: Surgical treatment outcomes of 57 patients
Authors: Laurian Claude , Cerceau Pierre , Paraskevas Nikos , Massoni Claudine , Marteau Veronique , Wassef Michel , Houdart Emmanuel , Bisdorff Annouk ,   Interdisciplinary Study Group for Vascular Malformations Lariboisière and Saint-Joseph Hospitals
Published: May 2020

Objectives To report the outcomes of surgical treatment of calf intramuscular venous malformations (IMVMs) on pain, functional limitation, and quality of life. Methods We retrospectively reviewed 57 consecutive patients who had surgery for IMVM of the posterior compartment of the leg between 2010 and 2015. Treatments were all done at a single institution. Results Patients presented with pain (52), muscle contracture (14), or pulmonary embolism (4). Muscle involvement included the soleus muscle (n = 28, 49%), the gastrocnemius muscle (n = 25, 43%), and deep muscles (n = 4, 7%). Complete excision was possible in 52 patients (91%) and partial excision in 5 (9%). Thirty-five of 46 patients who had an MRI follow-up at six months had no residual venous malformation. At the final follow-up (mean 39 months), 32 of 40 patients seen had no residual pain and 37 had no residual functional impairment. Conclusion In cases where IMVM is located in one muscle in the leg, we demonstrated that surgery yielded improvement in pain, function, and quality of life.
Randomized multicenter study on long-term complications of peripherally inserted central catheters positioned by electrocardiographic technique
Authors: Yin Yu-Xia , Gao Wei , Li Xu-Ying , Lu Wei , Deng Qian-Hong , Zhao Cui-Yun , Liu Xue-Rong , Cao Ming-Kun , Wang Lu-Ning , Zhang Hai-Jun 
Published: May 2020

Background The intracavitary electrocardiogram (IC-ECG) method has been used for the tip location of central venous access devices for the advantage of being safe, accurate and highly cost effective. However, long-term follow-up is rare. This randomized clinical trial aimed to evaluate the long-term complications of peripherally inserted central catheters (PICCs) positioned by the IC-ECG method. Methods We randomized 2250 patients who needed PICC placement to either a landmark length estimation supplemented by IC-ECG positioned group (ECG group) or the traditional landmark length estimation alone group (control group) in a 2:1 allocation. Post-procedural chest X-rays were applied to confirm tip position. Follow-up was performed monthly to six months. Standard statistics analyses were performed with the SAS 9.13 software, and p < 0.05 was considered significant. Results As evaluated by post-procedural chest X-ray, tip location in the ECG group had a first-attempt success (catheter tip located at optimal position) of 91.7% (95% confidence interval (CI): 90.3%–93.1%), significantly higher than 78.9% (95% CI: 76.0%–81.9%) observed in the control group (p < 0.001). At six-month follow-up, in the control group, frequency of total complications was 9.5%, including the exit site infection (4.0%), phlebitis (1.3%), deep venous thrombosis (1.5%), liquid extravasation (2.9%) and mechanical failure (1.9%). The IC-ECG group had significantly lower rates of complications (6.4%, p < 0.001), including the exit site infection (2.7%, p > 0.05), phlebitis (1.1%, p > 0.05), deep venous thrombosis (1.2%, p > 0.05), liquid extravasation (2.4%, p > 0.05) and mechanical failure (1.2%, p > 0.05). In the univariable logistic regression analysis, ECG method, other diseases and upper arms were the independent protective factors, and the number of adjustment procedures (n ≥ 2) were the independent risk factors of the complications. Conclusions The intra-procedural tip location by IC-ECG is more safe and accurate than the traditional method of verifying tip location only post-procedurally, by chest X-ray.
Hard return: the development and transformation process of social participation in stroke survivors; a qualitative study and initial theory
Authors: Zhou Xuan , Du Minxia , Weng Yingli , Zhou Lanshu 
Published: May 2020

Objectives: Given the characteristic of high disability rates, the successful return of stroke patients to society is increasingly becoming a serious challenge. This study aimed developing a theory to reveal the development and transformation process of social participation among stroke survivors as a foundation for creating strategies to improve their social participation. Design: A constructivist grounded theory approach using data from in-depth semi-structure interviews. Setting: The settings were various, including the stroke follow-up clinic, rehabilitation institutions, subjects’ homes, park, work unit, and rest home in Shanghai, China. Subjects: In all, 36 stroke survivors who have passed through the acute phase and returned home participated in this study to share their experiences of social participation and processes of changes from September 2017 to January 2019. Results: A substantive theory on the development and transformation process of social participation among stroke survivors was generated, which included four process ingredients: “in-orbit,” “off-orbit,” “returning orbit,” and “in-orbit again.” The core concept “hard return” revealed not only the tough development process but also the unsatisfactory change results. Both participation abilities and participation willingness had an important impact on social participation and also played a significant role in driving its development. Conclusion: This study has identified the development process of social participation in stroke survivors and “hard-return” suggests not only the tough process but also unsatisfactory results. Interventions targeted process ingredients seem to be potentially promising to improve stroke survivors’ social function outcomes.
Optimising the Learning Potential of Simulations Through Structural Transparency and Exploratory Guidance
Authors: Capelo Carlos , Silva Ana Lorga 
Published: May 2020

Background. Simulation-based learning environments are used extensively to support learning in complex business systems. Nevertheless, studies have identified problems and limitations due to cognitive processing difficulties. In particular, previous research has addressed some aspects of model transparency and instructional strategy and produced inconclusive results. Aim. This study investigates the learning effects of using transparent simulations (that is, showing users the internal structure of models) and exploratory guidance (that is, guiding learners so they are able to explore the simulation by themselves, supported by specific cognitive aids) from a mental models perspective. Method. A test based on a simulation experiment with a system dynamics model, representing a supply chain system, was performed. Participants are required to use the simulator to investigate some issues related to the bullwhip effect and other supply chain coordination concepts. Results. Participants provided with the more transparent strategy and offered the more exploratory guidance demonstrated better understanding of the structure and behaviour of the underlying model. However, our results suggest that while exploratory guidance is a beneficial method for understanding both model structure and behaviour, making only the model transparent is more limited in its effect.
Intraoperative use of transit time flow measurement improves patency of newly created radiocephalic arteriovenous fistulas in patients requiring hemodialysis
Authors: Cyrek Anna E , Bernheim Johannes , Juntermanns Benjamin , Husen Peri , Pacha Arkadius , Hoffmann Johannes N 
Published: May 2020

Background: The autologous arteriovenous fistula is the primary choice to establish hemodialysis access without high failure rates. Intraoperative ultrasound flow measurements of newly created autologous arteriovenous fistulas represent a possibility of quality control and may therefore be a tool to assess their functionality. The aim of our study was to correlate intraoperative blood flow with access patency. Methods: Between March 2012 and March 2015, intraoperative transit time flow measurements were collected on 89 patients. Measurements were performed 5–10 min after the creation of a standardized anastomosis using 3–6 mm flow probes. To examine the correlation between intraoperative blood flow and access patency, groups of patients with high (> 200 mL/min) versus low flow (< 200 mL/min) were enrolled. Patients were assessed clinically and with ultrasound every 3 months. Data were analyzed retrospectively. Results: In the current short-term follow-up, including 89 patients (age 62 ± 3 years), 61 (68.5%) of the autologous arteriovenous fistulas were currently being used in an observation period ranging from 3 months to 3 years (mean observation period 546 ± 95 days) postoperatively. The intraoperative blood flow in patients with functioning autologous arteriovenous fistula (78) was significantly higher than that of patients without functioning autologous arteriovenous fistulas (407 ± 25 vs 252 ± 42 mL/min, respectively; p < 0.005) (11). Conclusion: The intraoperative measurement of blood flow is a useful tool to predict the outcome of maturation in autologous arteriovenous fistula. With this method, technical problems can be detected and corrected intraoperatively. Routine implementation of intraoperative flow measurements has to be examined by prospective controlled trials.
A phase II study of atezolizumab for pretreated advanced/recurrent non-small cell lung cancer with idiopathic interstitial pneumonias: rationale and design for the TORG1936/AMBITIOUS study
Authors: Ikeda Satoshi , Kato Terufumi , Kenmotsu Hirotsugu , Ogura Takashi , Iwasawa Shunichiro , Iwasawa Tae , Kasajima Rika , Miyagi Yohei , Misumi Toshihiro , Yamanaka Takeharu , Okamoto Hiroaki 
Published: May 2020

Background: Approximately 10% of patients with non-small cell lung cancer (NSCLC) are complicated with comorbid interstitial pneumonia (IP) with a poor prognosis. The pharmacotherapy for advanced lung cancer occasionally induces fatal acute exacerbation of pre-existing IP. Due to the lack of prospective studies, there is an urgent need to establish a safe and effective pharmacotherapy, especially for second-line or later settings. Atezolizumab, an anti-programmed cell death-ligand 1 antibody, is thought to be the safest candidate for second-line therapy among various immune checkpoint inhibitors. Moreover, compared with patients without IP, the patients with comorbid IP may have higher tumor mutation burden (TMB) or microsatellite instability (MSI), which are partly associated with a more favorable response to immune checkpoint inhibitors. Methods: The Thoracic Oncology Research Group 1936/AMBITIOUS study is an ongoing, multicenter, single-arm, phase II trial to assess the safety and efficacy of atezolizumab for pretreated advanced/recurrent patients with NSCLC complicated with idiopathic, chronic fibrotic IP with a forced vital capacity of >70%. The patients will receive atezolizumab (1200 mg, day 1) every 3 weeks until the discontinuation criteria are met. The primary end point of this study is the 1-year survival rate, and a sample size of 38 patients is set. As a translational research, we will perform the analysis of TMB, somatic mutations, and MSI for nucleic acids extracted from archival tumor samples. Discussion: Since there is no standard second-line or later therapy of advanced NSCLC with IP, the results of this study are expected to have a major impact on clinical practice. Trial registration: Japan Registry of Clinical Trials, jRCTs031190084, registered 26 August 2019 - retrospectively registered, https://jrct.niph.go.jp/en-latest-detail/jRCTs031190084
Patient perspectives and experience on the diagnostic pathway of lung cancer: A qualitative study
Authors: Christensen Helle Marie , Huniche Lotte 
Published: May 2020

Objectives: Lung cancer is one of the most common types of cancer, with high mortality rate and a significant burden of symptoms. It is therefore important to assess patients’ perceived quality of life during the diagnostic process and treatment. Knowledge of and attention to patients’ perspectives, experiences, and expectations in relation to lung cancer diagnostic pathways is limited. The aim of the study is to contribute with patients’ and relatives’ experiences with and their assessment of the quality of a hospital-based lung cancer diagnostic pathway. Methods: A qualitative study was conducted, comprising participant observation with 20 patients and semi-structured interviews with further 19 patients referred to the Lung Cancer Package, which initiates a fast track diagnostic pathway in a hospital setting. Data were obtained over a period of 9 months and analysed in collaboration with an interdisciplinary team of health professionals. The purpose was to further develop existing management strategies of the fast track diagnostic pathway based on patient’s perspectives. Results: Patients associated the fast track diagnostic pathway with high levels of anxiety due to the immediate risk of a lung cancer diagnosis. Although patients experienced the fast track programme as very challenging, they still wanted to move through the diagnostic pathway as quickly as possible. The patients expressed a need for support from relatives and repeatedly required information in multiple formats from health professionals throughout the diagnostic pathway. Conclusions: The study provided insight into the need for developing the fast track diagnostic pathway with a focus on patient anxiety, network involvement, and information strategies. The results qualified clinical practice with an increased focus on managing patients’ anxiety, raised awareness to involve relatives in the diagnostic process, and relaying information in dialogue with patients and their relatives, including management strategies to support patients through diagnostic investigations in the fast track programme.
Magnetic resonance imaging to estimate tissue deformations during penile clamp application: A case series
Authors: Lemmens Joe , Peko Cohen Lea , Worsley Peter R , Everitt Chris , Broadbridge Jackie , Gefen Amit , Rees Rowland W , Drake Marcus , Macaulay Margaret C , Fader Mandy , Bader Dan L 
Published: May 2020

Background: Penile clamps provide a means of preventing urinary incontinence in males following radical prostatectomy. In order for the devices to function, significant mechanical loads need to be applied to the penile tissues to close the urethra. However, such loads have the potential to cause damage to the vulnerable skin and underlying soft tissues. Accordingly, the study aimed to estimate the magnitudes of tissue deformations resulting from penile clamp application in three individual cases. Methods: Three individuals were recruited who currently use penile clamps to manage urinary incontinence following radical prostatectomy. Magnetic resonance images (MRI) of the penis were taken to produce a series of high contrast coronal and sagittal images both before and during the application of two commercially available clamps, modified for MRI compatibility. Tissue thickness measurements were estimated with the clamps in-situ and normalised to the unloaded baseline state. Results: The estimated magnitude of tissue deformations resulting from clamp application ranged between 68% and 84%. There were minimal differences in these deformations between the clamp designs, both of which appeared effective in closing the urethra. Local stress concentrations were observed in the tissues, which were deformed around the shape of the clamp. Conclusions: MRI enabled quantification of local tissue deformation during penile clamp application. The results revealed that clamps created large tissue deformations in all three cases, regardless of design. This information could inform the development of new clamp designs and materials to minimise the potential for tissue damage. Level of evidence: 4