bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Anxiolytic Potential of Niranthin: In-vivo and Computational Investigations
Authors: Chopade Atul R. , Somade Prakash M. , Somade Pratik P. , Mali Suraj N. 
Published: November 2020

AbstractAnxiety is an unpleasant state, which can critically decrease the quality of life is often accompanied by nervous behaviour and rumination. Niranthin is a lignan isolated from various Phyllanthus sources. The literature survey on niranthin highlights wide ranges of the therapeutic potentials. In a present study, based on our previous investigations, we evaluated pure, isolated and characterized niranthin as an anxiolytic agent. The niranthin [6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole] was purchased from commercial source and further subjected for assessment of its anxiolytic potentials using popular animal models including Elevated plus-maze model/test (EPM) and Light & Dark Exploration test (L&D). GABA-A receptor mediation was evaluated by pretreating the mice with the GABA-A receptor antagonist Flumazenil before the EPM task. Molecular docking simulation studies (pdb id: 4COF) carried out by Vlife QSAR software showed that niranthin (docking score: − 62.1714 kcal/mol) have shown comparatively best docking score compared to the standard drug Diazepam (docking score: − 63.1568 kcal/mol). To conclude, Niranthin has probable potential in the management of anxiety disorder. Our in-silico and in-vivo analysis (indirectly) indicated the plausible role of GABA mediation for anxiolytic activity. Although, these studies are preliminary, future in depth experimental explorations will be required to use Niranthin as anti-anxiety drug in near future.
Graphic Abstract
Microstructure and mechanical properties of Ti3(Al,Ga)C2/Al2O3 composites prepared by in situ reactive hot pressing
Authors: Fang Yuan , Liu Xiaohua , Feng Yuxia , Zhu Jianfeng , Jiang Wei 
Published: November 2020

AbstractIn this study, Ti3(Al,Ga)C2/Al2O3 composites were successfully synthesized by in situ hot pressing at 1350 °C for 2 h using Ti, Al, TiC, and Ga2O3 as raw materials. X-ray diffraction and scanning electron microscopy were used for characterizing the phase identities and microstructures of the sintered composites. The dependence of the Vickers hardness and flexural strength on the Al2O3 content was found to be in single-peak type. Ti3(Al0.6,Ga0.4)C2/10.3vol%Al2O3 composite exhibited significantly improved mechanical properties. Vickers hardness and flexural strength of the composite reached 6.58 GPa and 527.11 MPa, which were 40% and 74% higher than those of Ti3AlC2, respectively. Formation of solid solution and incorporation of second phase of Al2O3 resulted in the opposite influence on the fracture toughness. Finally, the hardening and strengthening mechanisms were discussed in detail.
On-Orbit Observations of Conjuncting Space Objects Prior to the Time of Closest Approach
Authors: Scott Robert Lauchie , Thorsteinson Stefan , Abbasi Viqar 
Published: November 2020

AbstractConjunction assessment of space objects in Low Earth Orbit (LEO) generally uses information collected by ground-based space surveillance sensors. These sensors track both the primary object (normally an active satellite) and the secondary object (typically space debris). The tracking data is used to update both objects’ orbits for collision risk assessment. The primary satellite’s involvement in this process is that of a satellite in jeopardy - the primary satellite does not usually contribute tracking data on the secondary as they are typically unequipped to do so. In this paper, an examination how an at-risk LEO primary satellite could obtain optical tracking data on a secondary object prior to the Time of Closest Approach (TCA) and assess its own collision risk without the need for additional ground-based space surveillance data is performed. This analysis was made possible by using in-situ optical measurements of space objects conjuncting with the Canadian NEOSSat Space Situational Awareness R&D microsatellite. By taking advantage of the near “constant-bearing, decreasing range” observing geometry formed during a LEO conjunction, NEOSSat can collect astrometric and photometric measurements of the secondary object in the time prior to TCA, or in the multiple half-orbits preceding TCA. This paper begins by describing the in-situ phenomenology of optically observed conjunctions in terms of the observing approach, geometry and detected astrometric and photometric characteristics. It was found that conjuncting objects are detectable to magnitude 16 and astrometric observations can be used for position covariances in the computation of probability of collision. Illustrative examples are provided. In orbits prior to TCA, in-track positioning error is improved by a factor of two or more by processing space-based observations on a filtered position estimate of the secondary. However, cross-track positioning knowledge is negligibly improved due to the inherent astrometric measurement precision of the NEOSSat sensor and the oblique observing geometry during conjunction observations. A short analysis of object detectability where star trackers could be used to perform similar observations finds that larger payload-sized objects would generally be detectable. However, smaller debris objects would require higher sensitivity from the star tracker if employed for optical conjunction derisk observations.
MOFs-Based Nitric Oxide Therapy for Tendon Regeneration
Authors: Chen Jun , Sheng Dandan , Ying Ting , Zhao Haojun , Zhang Jian , Li Yunxia , Xu He , Chen Shiyi 
Published: November 2020

AbstractTendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for inducing the regeneration of injured tendon by angiogenesis. Here, in this study, a system that NO-loaded metal–organic frameworks (MOFs) encapsulated in polycaprolactone (PCL)/gelatin (Gel) aligned coaxial scaffolds (NMPGA) is designed and prepared for tendon repair. In this system, NO is able to be released in vitro at a slow and stable average speed of 1.67 nM h−1 as long as 15 d without a burst release stage in the initial 48 h. Furthermore, NMPGA can not only improve the tubular formation capability of endothelial cells in vitro but also obviously increase the blood perfusion near the injured tendon in vivo, leading to accelerating the maturity of collagen and recovery of biomechanical strength of the regenerated tendon tissue. As a NO-loaded MOFs therapeutic system, NMPGA can promote tendon regeneration in a shorter healing period with better biomechanical properties in comparison with control group by angiogenesis. Therefore, this study not only provides a promising scaffold for tendon regeneration, but also paves a new way to develop a NO-based therapy for biomedical application in the future.
Extending practical flow chemistry into the undergraduate curriculum via the use of a portable low-cost 3D printed continuous flow system
Authors: Penny Matthew R. , Tsui Natalie , Hilton Stephen T. 
Published: November 2020

AbstractContinuous flow chemistry is undergoing rapid growth and adoption within the pharmaceutical industry due to its ability to rapidly translate chemical discoveries from medicinal chemistry laboratories into process laboratories. Its growing significance means that it is imperative that flow chemistry is taught and experienced by both undergraduate and postgraduate synthetic chemists. However, whilst flow chemistry has been incorporated by industry, there remains a distinct lack of practical training and knowledge at both undergraduate and postgraduate levels. A key challenge associated with its implementation is the high cost (>$25,000) of the system’s themselves, which is far beyond the financial reach of most universities and research groups, meaning that this key technology remains open to only a few groups and that its associated training remains a theoretical rather than a practical subject. In order to increase access to flow chemistry, we sought to design and develop a small-footprint, low-cost and portable continuous flow system that could be used to teach flow chemistry, but that could also be used by research groups looking to transition to continuous flow chemistry. A key element of its utility focusses on its 3D printed nature, as low-cost reactors could be readily incorporated and modified to suit differing needs and educational requirements. In this paper, we demonstrate the system’s flexibility using reactors and mixing chips designed and 3D printed by an undergraduate project student (N.T.) and show how the flexibility of the system allows the investigation of differing flow paths on the same continuous flow system in parallel.
“Evacuate everyone south of that line” Analyzing structural communication patterns during natural disasters
Authors: Kušen Ema , Strembeck Mark 
Published: November 2020

AbstractIn this paper, we analyze more than 16 million tweets that have been sent from 6.1 million Twitter accounts and are related to nine natural disasters. As part of our analysis, we identify eight basic emotions conveyed in these tweets. We found that during natural disasters, social media messages at first predominantly express fear, while sadness and positive emotions increase in the immediate aftermath of the event. In this context, positive emotions contribute to the social phenomenon of emotional bonding and are often related to compassion, gratitude, as well as donations for disaster relief. In our analysis, we found that the users’ emotional expressions directly contribute to the emergence of the underlying communication network. In particular, we identified statistically significant structural patterns that we call emotion-exchange motifs and show that: (1) the motifs 021U and 021D are common for the communication of all eight emotions considered in this study, (2) motifs which include bidirectional edges (i.e. online conversations) are generally not characteristic for the communication of surprise, sadness, and disgust, (3) the structural analysis of a set of emotions (rather than a single emotion) leads to the formation of more complex motifs representing more complex social interactions, and (4) the messaging patterns emerging from the communication of joy and sadness show the highest structural similarity, even reaching a perfect similarity score at some point during the data-extraction period.
Temporal Unfolding of Micro-valences in Facial Expression Evoked by Visual, Auditory, and Olfactory Stimuli
Authors: Gentsch Kornelia , Beermann Ursula , Wu Lingdan , Trznadel Stéphanie , Scherer Klaus R. 
Published: November 2020

AbstractAppraisal theories suggest that valence appraisal should be differentiated into micro-valences, such as intrinsic pleasantness and goal-/need-related appraisals. In contrast to a macro-valence approach, this dissociation explains, among other things, the emergence of mixed or blended emotions. Here, we extend earlier research that showed that these valence types can be empirically dissociated. We examine the timing and the response patterns of these two micro-valences via measuring facial muscle activity changes (electromyography, EMG) over the brow and the cheek regions. In addition, we explore the effects of the sensory stimulus modality (vision, audition, and olfaction) on these patterns. The two micro-valences were manipulated in a social judgment task: first, intrinsic un/pleasantness (IP) was manipulated by exposing participants to appropriate stimuli presented in different sensory domains followed by a goal conduciveness/obstruction (GC) manipulation consisting of feedback on participants’ judgments that were congruent or incongruent with their task-related goal. The results show significantly different EMG responses and timing patterns for both types of micro-valence, confirming the prediction that they are independent, consecutive parts of the appraisal process. Moreover, the lack of interaction effects with the sensory stimulus modality suggests high generalizability of the underlying appraisal mechanisms across different perception channels.
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm
Authors: Shekhar Raja , Naseem Shano , Binota Jogeshwar , Varma Neelam , Malhotra Pankaj 
Published: November 2020

Objective/background:
B-cell neoplasms are clonal tumors of B cells at various stages of maturation, including diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic lymphoma (CLL), Burkitt lymphoma (BL), lymphoplasmacytic lymphoma (LPL)/Waldenström’s macroglob- ulinemia (WM), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and hairy cell leukemia (HCL). In this study, we analyzed the frequency of MYD88 L265P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasms.

Methods:
A total of 110 consecutive cases of B-cell neoplasms showing peripheral blood and/or bone marrow infiltration were included. MYD88 L265P mutation was detected by polymerase chain reaction amplification of exon 5 of MYD88 gene, followed by restriction fragment length polymorphism analysis.

Results:
Among the 110 cases, the major group was of CLL (54.5%, n = 60), followed by HCL. Other cases included MCL, LPL, DLBCL, SMZL, NMZL, FL, and BL. MYD88 L265P mutation was seen in 21 (19.1%) cases of B-cell neoplasm, whereas 89 (80.9%) cases were negative for MYD88 L265P mutation. It was most commonly seen in LPL/WM cases followed by HCL, SMZL, CLL, and MCL cases. No case of DLBCL, FL, and BL showed MYD88 L265P mutation. Statistically significant difference was seen for hemoglobin level in CLL cases, with MYD88 L265P mutated cases showing higher mean hemoglobin levels than MYD88 wild-type cases (p = .001). For other parameters, no statistically significant difference was noted between mutated and unmutated cases.

Conclusion:

MYD88 L265P mutation is seen in various B-cell neoplasms; it is most commonly seen in LPL/WM cases but not specific for it.
Complete regularity of Ellis semigroups of -actions
Authors: BARGE MARCY , KELLENDONK JOHANNES 
Published: November 2020

AbstractIt is shown that the Ellis semigroup of a$\mathbb Z$-action on a compact totally disconnected space is completely regular if and only if forward proximality coincides with forward asymptoticity and backward proximality coincides with backward asymptoticity. Furthermore, the Ellis semigroup of a$\mathbb Z$- or$\mathbb R$-action for which forward proximality and backward proximality are transitive relations is shown to have at most two left minimal ideals. Finally, the notion of near simplicity of the Ellis semigroup is introduced and related to the above.
Outcomes of an ambulatory care pharmacist-led antimicrobial stewardship program within a family medicine resident clinic
Authors: Westerhof Lindsey R. , Dumkow Lisa E. , Hanrahan Tarajo L. , McPharlin Samantha V. , Egwuatu Nnaemeka E. 
Published: November 2020

AbstractObjective:To determine whether an ambulatory care pharmacist (AMCP)-led intervention improved outpatient antibiotic prescribing in a family medicine residency clinic (FMRC) for upper respiratory tract infections (URIs), urinary tract infections (UTIs), and skin and soft-tissue infections (SSTIs).Design:Retrospective, quasi-experimental study comparing guideline-concordant antibiotic prescribing before and after an antimicrobial stewardship program (ASP) intervention.Setting:Family medicine residency clinic affiliated with a community teaching hospital.Participants:Adult and pediatric patients prescribed antibiotics for URI, UTI, or SSTI between November 1, 2017, and April 31, 2018 (pre-ASP group), or October 1, 2018, and March 31, 2019 (ASP group), were eligible for inclusion.Methods:The health-system ASP physician and pharmacist provided live education and pocket cards to FMRC staff with local guidelines as a quick reference. Audit with feedback was delivered every other week by the clinic’s AMCP. Guideline-concordance was determined based on the institution’s outpatient ASP guidelines.Results:Overall, 525 antibiotic prescriptions were audited (pre-ASP n = 90 and ASP n = 435). Total guideline-concordant antibiotic prescribing at baseline was 38.9% (URI, 53.3%; SSTI, 16.7%; UTI, 46.7%) and improved across all 3 infection types to 57.9% (URI, 61.2%; SSTI, 57.6%; UTI, 53.5%; P = .001). Significant improvements were seen in guideline-concordant antibiotic selection (68.9% vs 80.2%; P = .018), dose (76.7% vs 86.2%; P = .023), and duration of therapy (73.3% vs 86.2%; P = .02).Conclusions:An AMCP-led outpatient ASP intervention significantly improved guideline-concordant antibiotic prescribing for common infections within a FMRC.
Nutritional implications of dietary gluten avoidance among Canadians: results from the 2015 Canadian Community Health Survey
Authors: Mudryj Adriana N. , Waugh Anne K. , Slater Joyce J. , Duerksen Donald R. , Bernstein Charles N. , Riediger Natalie D. 
Published: November 2020

AbstractAdherence to a gluten-free diet (GFD) is the only available treatment for gluten-related disorders, although a GFD may also be followed for discretionary reasons. The main objectives of the present study were to (1) describe and test for differences in key nutrient intakes among Canadians who follow a GFD compared with Canadians with no dietary exclusions and (2) describe additional dietary avoidances adhered to by Canadians who avoid gluten. We conducted a secondary analysis of the cross-sectional 2015 Canadian Community Health Survey-Nutrition Survey, which included a general health survey and 24-h dietary recall (n20 487). Participants were categorised as those who avoid dietary gluten and those who reported no avoidances. Key nutrient intakes were assessed, as a percentage of Dietary Recommended Intakes, including fibre, B vitamins, vitamin D, Ca, Fe, Na and Zn, and compared between the two groups usingttests. Canadians who avoided gluten had significantly lower intakes of folate, vitamin B12, vitamin D, Fe, Na and Ca compared with those who did not avoid any food groups. However, Canadians who reported following a GFD were significantly more likely to use vitamin or mineral supplements in the past 30 d. More than 20 % of those who avoided gluten also avoided dairy products. Findings suggest that following a GFD places Canadians at risk for nutrient inadequacies, particularly folate, Ca and vitamin D. Further research is required to further examine how multiple dietary avoidances among those who avoid gluten may contribute to dietary inadequacies.
Lender Forbearance
Authors: Bird Andrew , Ertan Aytekin , Karolyi Stephen A. , Ruchti Thomas G. 
Published: November 2020

AbstractWe use a threshold-based design to study ex post discretion in lenders’ contractual enforcement of covenant violations. At preset thresholds, lenders enforce contractual breaches only infrequently, but this enforcement is associated with material consequences (e.g., fees and renegotiations). Enforcement varies significantly over time and peaks when credit conditions are tightest, indicating that enforcement is procyclical. Costly coordination reduces enforcement: Syndicates with ex ante restrictive voting requirements enforce at lower rates. Consistent with theories of lender competition and implicit contracting, enforcement rates are lower for borrowers with access to alternative sources of financing and well-reputed lead arrangers.
‘ACCEPTABLE TRUTHS’ DURING THE FRENCH RELIGIOUS WARS
Authors: Roberts Penny 
Published: November 2020

AbstractThis paper seeks to provide some historical perspective on contemporary preoccupations with competing versions of the truth. Truth has always been contested and subject to scrutiny, particularly during troubled times. It can take many forms – judicial truth, religious truth, personal truth – and is bound up with the context of time and place. This paper sets out the multidisciplinary approaches to truth and examines its role in a specific context, that of early modern Europe and, in particular, the French religious wars of the sixteenth century. Truth was a subject of intense debate among both Renaissance and Reformation scholars, it was upheld as an absolute by judges, theologians and rulers. Yet, it also needed to be concealed by those who maintained a different truth to that of the authorities. In the case of France, in order to advance their cause, the Huguenots used subterfuge of various kinds, including the illicit carrying of messages. In this instance, truth was dependent on the integrity of its carrier, whether the messenger could be trusted and, therefore, their truth accepted. Both sides also sought to defend the truth by countering what they presented as the deceit of their opponents. Then, as now, acceptance of what is true depends on which side we are on and who we are prepared to believe.
Improving sentiment analysis with multi-task learning of negation
Authors: Barnes Jeremy , Velldal Erik , Øvrelid Lilja 
Published: November 2020

AbstractSentiment analysis is directly affected by compositional phenomena in language that act on the prior polarity of the words and phrases found in the text.Negationis the most prevalent of these phenomena, and in order to correctly predict sentiment, a classifier must be able to identify negation and disentangle the effect that its scope has on the final polarity of a text. This paper proposes a multi-task approach to explicitly incorporate information about negation in sentiment analysis, which we show outperforms learning negation implicitly in an end-to-end manner. We describe our approach, a cascading and hierarchical neural architecture with selective sharing of Long Short-term Memory layers, and show that explicitly training the model with negation as an auxiliary task helps improve the main task of sentiment analysis. The effect is demonstrated across several different standard English-language data sets for both tasks, and we analyze several aspects of our system related to its performance, varying types and amounts of input data and different multi-task setups.