bluuebunny/crossref_metadata_2025_split huggingface dataset:
ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity
Authors: Haines Brian B. , Denslow Agnieszka , Grzesik Peter , Lee Jennifer S. , Farkaly Terry , Hewett Jacqueline , Wambua Daniel , Kong Lingxin , Behera Prajna , Jacques Judith , Goshert Caitlin , Ball Michael , Colthart Allison , Finer Mitchel H. , Hayes Melissa W. , Feau Sonia , Kennedy Edward M. , Lerner Lorena , Quéva Christophe 
Published: December 2020

Abstract
ONCR-177 is an engineered recombinant oncolytic herpes simplex virus (HSV) with complementary safety mechanisms, including tissue-specific miRNA attenuation and mutant UL37 to inhibit replication, neuropathic activity, and latency in normal cells. ONCR-177 is armed with five transgenes for IL12, FLT3LG (extracellular domain), CCL4, and antagonists to immune checkpoints PD-1 and CTLA-4. In vitro assays demonstrated that targeted miRNAs could efficiently suppress ONCR-177 replication and transgene expression, as could the HSV-1 standard-of-care therapy acyclovir. Although ONCR-177 was oncolytic across a panel of human cancer cell lines, including in the presence of type I IFN, replication was suppressed in human pluripotent stem cell–derived neurons, cardiomyocytes, and hepatocytes. Dendritic cells activated with ONCR-177 tumor lysates efficiently stimulated tumor antigen–specific CD8+ T-cell responses. In vivo, biodistribution analyses suggested that viral copy number and transgene expression peaked approximately 24 to 72 hours after injection and remained primarily within the injected tumor. Intratumoral administration of ONCR-177 mouse surrogate virus, mONCR-171, was efficacious across a panel of syngeneic bilateral mouse tumor models, resulting in partial or complete tumor regressions that translated into significant survival benefits and to the elicitation of a protective memory response. Antitumor effects correlated with local and distant intratumoral infiltration of several immune effector cell types, consistent with the proposed functions of the transgenes. The addition of systemic anti–PD-1 augmented the efficacy of mONCR-171, particularly for abscopal tumors. Based in part upon these preclinical results, ONCR-177 is being evaluated in patients with metastatic cancer (ONCR-177-101, NCT04348916).
Is it Possible to Connect Recognition with a Post-Identitarian Notion of Solidarity?
Authors: Fischer Mariana 
Published: December 2020

Abstract
This article intends to confront the perspectives of Axel Honneth and Judith Butler on solidarity. Honneth emphasizes the role of identities and a notion of solidarity connected to cultural backgrounds, shared narratives and world images. Butler, on the other hand, fears that this form of solidarity, based on similitudes, might lead to social narcissism. She believes that it is possible to foster another kind of solidarity, one based on our shared vulnerability and on experiences that can make us recognize that we are not identical to ourselves. Investigating the tensions between these two very dissimilar points of view will help to explore possible connections between post-identitarian forms of solidarity and affects such as desire and mourning, which are frequently at stake in social struggles.
Intellectual Innovations in Georgia (11th-9th Centuries BC)
Authors: Licheli Vakhtang 
Published: December 2020

Abstract
The multilayer archaeological site Grakliani hill is located in one of the main contact zones of Transcaucasia. It shows a very intensive level of communication with other cultures from the 2nd millenium BC till the 3rd century BC and a high level of development of Kartli (Iberia Caucasica) society. Two inscriptions made in unknown script (probably a local version of Aramaic script) were discovered in a shrine of the 11th-9th centuries BC. A group of weights and tokens, also of the 11th-9th centuries BC was discovered in the excavations of Grakliani Hill and the satellite site of Tsina Gora. The Achaemenid period remains are also of special interest, including Greek style architecture details.
Investigating the Internationalisation of State Nobilities: A Reflexive Return to Double Game Strategies
Authors: Bigo Didier , Cohen Antonin , _ _ 
Published: December 2020

Abstract
In the second part of this interview, Yves Dezalay – an Emeritus cnrs researcher who spent much of his professional career at the Centre of European Sociology in Paris – takes us even deeper into his trajectory as a scholar. In situating the institutional-intellectual spaces in which he circulated, Dezalay brings to life the inter/intra-disciplinary boundaries he regularly crossed and even forced open in his quest to understand the complexity of interconnections between the national and the international, the professional and the political, as well as the law and the state in overlapping processes of globalization. Speaking about his long-term collaboration with professor of law Bryant Garth, Dezalay also elaborates a collaborationist methodology of transversal, multi-sited research.
Italian Perspectives on Pandemic Responses: Tracing Early Critiques from Europe’s First Lockdown
Authors: Fumagalli Andrea , Gandini Sara , Morini Cristina 
Published: December 2020

Abstract
This paper is a translation of three early critiques of the responses of the Covid-19 pandemic in Italy, each addressing a unique facet and different perspective of Europe’s first lockdown. Through bringing together these memorial traces, the article captures the heterogeneity of discussions taking place on the left at the very beginning of the pandemic, destabilizing a totalizing framing of Covid responses through simple binaries such as health vs economics or individual rights vs the collective good. Crisitina Morini addresses the ambivalences around the term ‘care’ (in Italian meaning both ‘attention’ and ‘cure’). Grounded in feminist economics, she argues for the establishment of a self-determination income envisioned as an unconditional and universal income, not linked to working positions. Sara Gandini ponders the possibility of turning anger into a political force and questions what forms this could take. Highlighting the problems related to turning a public health issue into one of national security, Gandini probes the politics of acceptability around Covid-related deaths against non-Covid related deaths, particularly deaths precisely exacerbated by confinement strategies. She speaks also of the silencing and policing of dissent when one tries to raise such issues in the public space. Lastly, Andrea Fumagalli uses the idea of crisis as an opportunity to rethink social and economic issues. These include readjusting the balance between private and public healthcare, (especially as Covid treatments are not very profitable), the implementation of a major European investment plan relating to social infrastructure and the environment, which will relaunch the European economy. Though these critiques were formulated at the start of the pandemic. many of the arguments and questions the authors asked themselves at the time remain highly topical: the role of welfare and income, the regulatory devices (including gender) that risk passing using the fight against the pandemic; all of which are central to maintaining a lucidity of analysis and to be resistant witnesses, politicizing anger to turn it into an agency that takes advantage of this difficult experience to build a slightly better world.
Mesoscale Prediction in the Antarctic Using Cycled Ensemble Data Assimilation
Authors: Riedel Christopher P. , Cavallo Steven M. , Parsons David B. 
Published: December 2020

AbstractDue in part to sparse conventional observation coverage in the Antarctic region, atmospheric studies in this part of the globe often rely more heavily on numerical models. Model representation of atmospheric processes in the Antarctic remains inferior to representation in the Northern Hemisphere midlatitudes. Poor representation may be related to inaccurate model analyses that do not optimally utilize the limited observation network. Here, the ensemble Kalman filter (EnKF) data assimilation (DA) technique is employed in lieu of variational DA techniques to investigate impacts on model analysis accuracy. This DA technique [provided by the Data Assimilation Research Testbed (DART)] is coupled with a polar-modified, mesoscale numerical model that together compose Antarctic-DART (A-DART). A-DART is cycled with DA and run over a 1-month period, assimilating only conventional observations. Results show relatively good agreement between A-DART and observations. Comparison with radiosonde temperature and geostationary satellite wind observations shows large differences between RMSE and ensemble spread in the upper troposphere. The analysis increment shows large values in the eastern Atlantic–western Indian Oceans associated with geostationary satellite wind observations. Further evaluation determines that geostationary satellite wind observations may be biased in this region. Overall, this baseline demonstration of ensemble-based modeling applied in the Antarctic produced short-term forecasts that were competitive with two operational modeling systems while assimilating on the O(106) fewer observations. A-DART is capable of assimilating additional observations for a variety of applications. This study highlights the capability of applying this ensemble-based DA technique for process and forecast studies in an observation-sparse region.
Giant thoracic ganglioneuroma with lymph node infiltration of a child: a case report
Authors: Hettiarachchi Mathula , Dharmadasa Chanuka , Wijeyananda Ashoka , Hettiarachchi Kapila , Samarasinghe Bandula 
Published: December 2020

Abstract
Background
Ganglioneuroma is a rare neurogenic tumor which could grow into massive size in the thorax with minimal or no symptoms. Resection of these tumors will be challenging in view of large size and vascular encasement. Here, we report resection of a thoracic ganglioneuroma in a child with infiltration of spinal canal and lymph node metastasis, which is a very rare occurrence.

Case presentation
A 3-year and 10-month-old girl presented with a left side thoracic mass with minimal symptoms and signs. After the initial imaging with ultrasound scan and cross-sectional imaging, she had a true cut biopsy of the lesion confirming the diagnosis of ganglioneuroma. On exploration, she had a paraspinal thoracic mass extending from level of arch of aorta down to diaphragm with evidence of tumor infiltration of the intercostal spaces and spinal canal in multiple vertebral levels. Pathologically, she had infiltrated lymph nodes which were encircling the lower thoracic aorta. The tumor was resected successfully, and she recovered with a good functional status.

Conclusion
Thoracic ganglioneuroma has a good prognosis after complete resection even with spinal canal and lymph node infiltration. The resection could be arduous in case of massive size and vascular encasement; hence, benefit versus risk of complete resection should be carefully weighed.
Dosimetric effect of the intestinal gas of online adaptive stereotactic body radiotherapy on target and critical organs without online electron density correction for pancreatic cancer
Authors: Su Chen , Okamoto Hiroyuki , Nishioka Shie , Sakasai Tatsuya , Fujiyama Daisuke , Miura Yuki , Tsunoda Yuki , Kuwahara Junichi , Nakamura Satoshi , Iijima Kotaro , Chiba Takahito , Kaga Keita , Takemori Mihiro , Nakayama Hiroki , Katsuta Shouichi , Inaba Koji , Igaki Hiroshi , Nakayama Yuko , Itami Jun 
Published: December 2020

Objective:
This study aimed to assess the dosimetric effect of intestinal gas of stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) on target and critical organs for pancreatic cancer without online electron density correction (EDC).

Methods:
Thirty pancreatic cancer patients who underwent online SMART were selected for this study. The treatment time of each stage and the total treatment time were recorded and analyzed. The concerned dose-volume parameters of target and organs-at-risk (OAR) were compared with and without an intestinal gas EDC using the Wilcoxon-signed rank test. Analysis items with p value &lt; 0.05 were considered statistically significant. The relationships between dosimetric differences and intestinal gas volume variations were investigated using the Spearman test.

Results:
The average treatment time was 82 min, and the average EDC time was 8 min, which accounted for 10% of the overall treatment time. There were no significant differences in CTV (GTV), PTV, bowel, stomach, duodenum, and skin (p &gt; 0.05) with respect to dose volume parameters. For the D max of gastrointestinal organs (p = 0.03), the mean dose of the liver (p = 0.002) and kidneys (p = 0.03 and p = 0.04 for the left and right kidneys, respectively), there may be a risk of slight overestimation compared with EDC, and for the D max of the spinal cord (p = 0.02), there may be a risk of slight underestimation compared with EDC. A weak correlation for D 95 in the PTV and D 0.5 cc in the duodenum was observed.

Conclusion:
For patients with similar inter-fractional intestinal gas distribution, EDC had little dosimetric effects on the D 0.5 cc of all GI organs and dose volume parameters of target in most plans.

Advances in knowledge:
By omitting the EDC of intestinal gas, the online SMART treatment time can be shortened.
Polynomial expansions via embedded Pascal’s triangles
Authors: Provost Serge B. , Ratemi Wajdi M. 
Published: December 2020

An expansion is given for polynomials of the form (ω + λ1) · · ·(ω +λn). The coefficients of the resulting polynomials are related to their roots, and a system of equations that enables one to numericallydetermine the roots in terms of the coefficients is specified. The case where all the roots λi are equal is considered as well. A multinomial extension to polynomials of the form (x1+ · · · + xI )n is then provided. As it turns out, the coefficients of the monomials contained in the resulting polynomial expansion can be determined in terms of the coefficients of the monomials included in the expansion of (x1+ · · · + xI-1 )n and the rows of embedded Pascal’s triangles of successive orders. An algorithm is provided for generating and concatenating these rows, with the particulars of its implementation by means of the symbolic computation software Mathematica being discussed as well. Potential applications of such expansions to combinatorics and genomics are also suggested.
On characterization of horizontal biharmonic curves in H^2 × R
Authors: Körpinar Talat , Turhan Essin 
Published: December 2020

In this paper, we study biharmonic curves in H2 × R. We show that all of them are helices. By using the curvature and torsion of the curves, we give some characterizations of horizontal biharmonic curves in H2 × R.
Classification of magnetospheric responses to interaction with diamagnetic structures of slow solar wind
Authors: Parhomov Vladimir , Eselevich Viktor , Eselevich Maxim , Dmitriev Alexei , Suvorova Alla , Vedernikova Tatyana 
Published: December 2020

We propose a possible classification of the responses of the magnetosphere to the interaction with diamagnetic structures (DS), which form the basis of the slow solar wind. The main determinants of the classification are the value and orientation of the vertical component Bz of the interplanetary magnetic field (IMF) and the solar wind density N. We have identified three types of magnetospheric responses. Type 1 has two subtypes whose main difference is the presence or absence of auroras on the day side of the magnetosphere. Within an hour before DS arrival, Bz has a positive value (up to 12 nT) or fluctuates about 0 in the range from –1 to +1 nT. For both subtypes, the duration of substorm disturbances approximately coincides with the duration of DS, and their intensity does not exceed AE~500 nT. Type 2 is characterized by the fact that before the contact with DS positive IMF Bz (0–10 nT) is recorded for an hour, and at the interface of DS a rapid (≤2 min) change in the orientation of the IMF vertical component from north to south occurs. For type 3, Bz within an hour before the contact with DS is negative (from –10 to 0 nT).
We address the problem of DS energy transfer to the magnetosphere.
Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL)
Authors: Jalenques Isabelle , Cyrille Diane , Derost Philippe , Hartmann Andreas , Lauron Sophie , Jameux Clara , Tauveron-Jalenques Urbain , Guiguet-Auclair Candy , Rondepierre Fabien ,   for The Syndrome de Gilles de La Tourette Study Group
Published: December 2020

IntroductionThe Gilles de la Tourette Syndrome–Quality of Life Scale (GTS-QOL) is a self-rated disease-specific questionnaire to assess health-related quality of life of subjects with GTS.Our aim was to perform the cross-cultural adaptation of the GTS-QOL into French and to assess its psychometric properties.MethodsThe GTS-QOL was cross-culturally adapted by conducting forward and backward translations, following international guidelines. The psychometric properties of the GTS-QOL-French were assessed in 109 participants aged 16 years and above with regard to factor structure, internal consistency, reliability and convergent validity with the MOVES (Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey) and the WHOQOL-BREF (World Health Organization Quality of Life Brief).ResultsExploratory factor analysis of the GTS-QOL-French resulted in a 6-factor solution and did not replicate the original structure in four subscales. The results showed good acceptability (missing values per subscale ranging from 0% to 0.9%), good internal consistency (Cronbach’s alpha ranging from 0.68 to 0.94) and good test–retest reliability (intraclass correlation coefficients ranging from 0.70 to 0.81). Convergent validity with the MOVES and WHOQOL-BREF scales showed high correlations.DiscussionOur study provides evidence of the good psychometric properties of the GTS-QOL-French. The cross-cultural adaptation and validation of this specific instrument will make it possible to assess health-related quality of life in French-speaking subjects with GTS. The GTS-QOL-French could be recommended for use in future research.
Comparative evaluation of antimicrobial potential of herbal extracts on Streptococcus mutans and Enterococcus faecalis: An in vitro study
Authors: Tatekalva Pranati , Subbaiyan Haripriya , Rajesh Kumar Shanmugam 
Published: December 2020

Though aloe vera extract, green tea extract and coriander oil are proven antimicrobial agents, very little information is available regarding its effects on oral bacteria, Streptococcus mutans,which is responsible for initiating caries and Enterococcus faecalis, responsible for failure of root canal treatment. Objective: To find the antimicrobial activity of aloe vera extract, black tea extract and coriander oil against S. mutans and E. faecalis. Materials and Methods: The agar well diffusion method was used to determine the antibacterial activity of Aloe vera extract, black tea extract and coriander oil. Different concentration of prepared plant extracts and coriander seed oil (50 & 100 µl) was incorporated into the wells and the plates containing S. mutans and E. faecalis were incubated at 37 ºC for 24h. The antibiotic (amoxicillin 30 µl) was used as positive control. Zone Of Inhibition (ZOI) was recorded in each plate. Results: For S. mutans, the maximum ZOI was created by coriander oil with a diameter of 25.00±0.58 mm at 50 µl and for E. faecalis, maximum ZOI was created by aloe vera extract 16.00±0.58 mm at 100 µl concentration which were far better than the control: amoxicillin 30 µl concentration.
Conclusion: The extracts of Aloe vera, black tea and coriander oil, showed significant activity against the investigated microbial strains, Streptococcus mutans and Enterococcus faecalis which further helps in the development of new topical agents that help in reducing the numbers of these organisms present in the oral cavity.

Keywords
Oral microbiota; Aloe vera; black tea; coriander oil; E. faecalis; S.mutans.
Memobase – Das Portal zum audiovisuellen Erbe der Schweiz
Authors: Rauh Felix 
Published: December 2020

Zusammenfassung
Mit dem multimedialen Portal Memobase macht Memoriav, die Fachstelle für die Erhaltung des audiovisuellen Erbes der Schweiz, Bilder und Töne aus Gedächtnisinstitutionen sicht- und hörbar. Das Portal ermöglicht die Suche in Beständen aus mehr als 60 Institutionen aus allen Sprachregionen der Schweiz. Dazu gehören auch die bewegten Bilder der mehrsprachigen Schweizer Filmwochenschau oder Filme über die humanitären Aktionen des Internationalen Komitees vom Roten Kreuz.
On cupstones in South China
Authors: Fu Yongxu 
Published: December 2020

Abstract
In South China, cupstones, a kind of artifact of ancient cultures bearing unique regional characteristics, are widely distributed. Cupstones are cobbles with concave recesses (cupules) formed by direct processing or wearing for a long-time of use. According to the numbers of the sides exhibiting such recesses, cupstones can be classified into those bearing recesses on one side, on two sides, on three sides, and on four or more sides. The cupstones are distributed in two distinct areas: the inland and coastal regions. They were made and used starting during the Upper Paleolithic Age and persisted into the Warring States period and Qin and Han dynasties, and perhaps even later. These artifacts experienced a development that saw their increase over time in quantity and quality as they changed from being made in rough to finer form. The function of cupstones may not be single; they might have been used to process nuts or shells, or perhaps they functioned as implements or tools for processing stone implements, or as a kind of multipurpose artifact.
A DSL for Resource Checking Using Finite State Automaton-Driven Symbolic Execution
Authors: Fülöp Endre , Pataki Norbert 
Published: December 2020

Abstract
Static analysis is an essential way to find code smells and bugs. It checks the source code without execution and no test cases are required, therefore its cost is lower than testing. Moreover, static analysis can help in software engineering comprehensively, since static analysis can be used for the validation of code conventions, for measuring software complexity and for executing code refactorings as well. Symbolic execution is a static analysis method where the variables (e.g. input data) are interpreted with symbolic values.
Clang Static Analyzer is a powerful symbolic execution engine based on the Clang compiler infrastructure that can be used with C, C++ and Objective-C. Validation of resources’ usage (e.g. files, memory) requires finite state automata (FSA) for modeling the state of resource (e.g. locked or acquired resource). In this paper, we argue for an approach in which automata are in-use during symbolic execution. The generic automaton can be customized for different resources. We present our domain-specific language to define automata in terms of syntactic and semantic rules. We have developed a tool for this approach which parses the automaton and generates Clang Static Analyzer checker that can be used in the symbolic execution engine. We show an example automaton in our domain-specific language and the usage of generated checker.