bluuebunny/crossref_metadata_2025_split huggingface dataset:
A long term condition / disability, loneliness, and social isolation are associated with lower quality of life, but a sense of coherence buffers the adverse effects: a cross sectional study in older people
Authors: Woerden Hugo van , Angus Neil J. , Kiparoglou Vasiliki , Atherton Iain Maitland , Leung Janni 
Published: January 2020

Abstract
Background The impact of disability, long term conditions, rurality, living alone, and being a carer on health has some evidence base. The extent to which a strong sense of coherence, a factor hypothesised to promote wellbeing, may moderate these associations is unknown. A model of physical, environmental and social factors on quality of life was tested, with particular emphasis on whether a strong sense of coherence (SoC) buffered these determinants of quality of life.Methods A cross sectional postal survey was undertaken of a random sample of 3,000 individuals over 65 years, across a rural population. Physical, environmental, and psychological variables were assessed against quality of life using ANOVA and a generalised linear model including the interaction effects of SoC.Results Of 1,547 responses, 1,471 were analysable and provided permission for research use. ANOVA demonstrated that age, gender, long-term condition / disability (LTC-D), living alone, >20 hours unpaid care for others per week, SoC, and loneliness, were associated with lower quality of life (p<0.01). There were strong correlations (p>0.01), between age and LTC-D, living alone, and poor SoC. Living alone was correlated with emotional and social loneliness; but those with higher SoC were less likely to experience loneliness. In an adjusted generalised linear model, significant associations with a lower quality of life were observed from: LTC-D, emotional loneliness and social loneliness (B= -0.44, -0.30, and -0.39, respectively, all p<0.001). The only interaction with SoC that was statistically significant (at p<0.05) was LTC-D. A stronger sense of coherence buffered the negative effects of long-term condition / disability on quality of life.Conclusions This study is novel in examining the relationship between the presence of a LTC-D and loneliness in an older rural population. The physical, environmental and social factors examined, identified long-term conditions / disability and loneliness to be the strongest factors associated with quality of life. SoC somewhat buffered the adverse effect of LTC-D on quality of life, but did not do so for loneliness. Future research to understand what could be done to improve quality of life in a rural context is warranted.
Opioid overdose death in Wales: A linked data autopsy study
Authors: Jones Matthew Balquin , Bradshaw Ceri , Fuller Gordon , John Ann , Jones Jenna , Moore Chris , Snooks Helen , Watkins Alan 
Published: January 2020

Abstract
BackgroundFatal opioid overdose is a growing public health problem, the incidence of which is rising in the UK and in other western countries. We sought to describe factors associated with deaths, demographic characteristics, and service usage patterns of decedents of opioid overdose in a nation of the UK.MethodsWe carried out a retrospective cross-sectional analysis of opioid related deaths between 01/01/2012 and 11/10/2018 in Wales, UK, as identified from Office for National Statistics data. In addition to ONS records, the Welsh Demographic Service and National Health Service datasets were interrogated for records spanning the preceding three years. Records were linked on an individual basis using a deterministic algorithm. Decedents’ circumstances of death, demographic characteristics, and residency and service use patterns were described. Additionally, data pertaining to circumstances of death were briefly analysed.Results638 people died of opioid overdose in Wales between 01/01/2012 and 11/10/2018. Decedents were mostly male and around 50 years of age. Incidence per head of population was higher at the end of this period, peaking in 2015. In the 3 years prior to death the majority of decedents changed address at least once, but rarely moved far geographically. Over 80% of decedents visited the ED, the majority via emergency ambulance; over 60% were admitted to hospital; and over 30% visited specialist drug services on one or more occasion. Decedents who did not attend drug services were more likely to have died intentionally.ConclusionsHigh risk opioid users are often men of around 50 years of age living peripatetic lifestyles. It appears that those at high risk of dying from opioid overdose death use emergency medical services and are admitted to hospital comparatively often. They are less likely to visit specialist drug services however. Group differences between high risk opioid users who visit specialist drug services and those who do not appear to exist in relation to suicidality. Further research is needed in to delivering abstinence focussed or harm reduction based interventions via emergency services or inpatient hospital settings, and in understanding differences in suicidality between drug service attenders and non-attenders.
Oral Health-Related Quality of Life and Self-Esteem of Children with Post Traumatic Stress Disorder Living in War Zones: A case-control study
Authors: Hamid Sulaf Hasan 
Published: January 2020

Abstract
Background The aim of the recent study was to evaluate oral health-related quality of life (OHRQoL) and self-esteem (SE) in a group of Syrian children with post-traumatic stress disorder (PTSD) living in war zones and to compare results with healthy controls.Methods A total of 119 children (57 PTSD children vs. 62 healthy controls) aged between 10 and 14 years joined the present study. Child Post Traumatic Stress Disorder Reaction Index (CPTSD-RI) was utilized to confirm the diagnosis of PTSD symptoms. Child Perception Questionnaire (CPQ 11-14 ) was used to study OHRQoL. SE was measured with a subscale of the Child health questionnaire-child form87 (CHQ-CF87). T-tests for independent samples and Chi-square test utilized for in assessing the differences between groups.Results PTSD children had significantly more oral symptoms such as bleeding gums ( p =0.001), mouth and food between teeth ( p =0.000) when compared to healthy controls. They also had more troubles in sleeping ( p =0.019) and chewing hard food ( p =0.001). In addition, PTSD children had significantly ( p =0.000) more difficulty in opening their mouth wide and eating hot or cold food. They felt unsure about their selves ( p =0.009) and felt unsecure about health ( p =0.025) and appearance ( p =0.000). Children with PTSD showed troubles in attention ( p =0.001) and doing homework ( p =0.000). They also avoided both activities ( p =0.001), being around other children ( p =0.007) and even felt left out ( p =0.015) more frequently than healthy peers. SE scores were lower in PTSD children when compared to controls (60.96±18.71 vs. 81.01±11.13 respectively).Conclusions PTSD had negative impact on OHRQoL and SE of war-affected children. More studies are needed to confirm whether improving symptoms of PTSD may lead to better SE and OHRQoL.
Complete genome sequence analysis of a novel granaticin producer, Streptomyces sp. A1013Y
Authors: Zheng Shenglan , Zhu Yunping , Liu Kaifeng , Li Jinlong 
Published: January 2020

Abstract
Granaticin is a kind of antibiotics with the function of anticancer, antibacterial, anticoccidial. Streptomyces sp. A1013Y is a new strain isolated from soil with granaticin-producing ability. The genome information was analyzed for the further study of granaticin. The present work reported the complete genome of S. sp. A1013Y, which contains a 7,646,296 bp chromosome with an average GC content of 71.59%. A total of 7361 CDSs, including 66 tRNA genes, 18 rRNA genes and 23 clusters, were identified in the genome. With homologous recombination, an in-frame deletion mutant was constructed to confirm the granaticin cluster. The fermentation liquid of the mutant did not contain granaticin based on HPLC and LC-MS analysis, indicating that S. sp. A1013Y is a granaticin producer. Comparing the granaticin biosynthesis cluster of S. sp. A1013Y with Streptomycesviolaceoruber Tü22 and Streptomyces vietnamensis GIMV4.0001T, which were sequenced and produce granaticin, the similarity between the granaticin clusters was 78% and 83% respectively, but some genes still weren’t identified in the granaticin biosynthesis cluster. The phylogenetic analysis and ANI value between S. sp. A1013Y and other Streptomyces species, including S. vietnamensis GIMV4.0001T, were all below 85%, which showed that S. sp. A1013Y was probably a novel streptomyces strain that produced granaticin. The whole genome information of S. sp. A1013Y provides a valuable foundation for future granaticin analyses as well as biomedicine applications.
Socio-Demographic and Clinical Predictor Variables on CD4 Cell Count Change among HIV Positive adults; a Structural Equations Modelling
Authors: Seyoum Awoke , Ndlovu Principal Ndlovu , Zewotire Temesgen Zewotire 
Published: January 2020

Abstract
Background: The prevalence of HIV/AIDS among adult individuals has been increasing in Sub-Sahara African countries over the last decade. In Ethiopia , the prevalence of HIV among adults was 1%. Hence, 23, 000 people were newly infected with HIV and 11,000 people were died because of AIDS related illness in 2018. The purpose of this study was to identify the most significant socio-demographic, economic, individual and clinical determinants of CD4 cell count change in HIV positive adults who initiated HAART at Felege Hiwot Teaching and Specialized Hospital, North-West Ethiopia. Methods: A secondary and retrospective study design was conducted on 792 HIV positive adults. A structural equation modeling was employed to identify the socio-demographic and clinical covariates that have a statistically significant effect on the status of CD4 cell count change. Results: Literate patients, patients living with partner, patients living in urban area, patients disclosed the disease to family members, high income , ownership of cell, age and sex (male) were statistically significant variables. Conclusion: There was direct relation between socio-demographic variables with retention of HIV positive individuals in HAART program. There was also a direct and significant effect of clinical variables on adherence competence and adherence on CD4 cell change. Retention of patients in the HAART program had direct and significant effect on CD4 cell count change. This finding will be important for policy makers, health officials and for patients to easier access to healthcare service. Keywords: Socio-demographic, clinical factors, individual characteristics, Structural equation, CD4count change
Aggregation Prone Regions in Antibody Sequences Raised Against Vibrio cholerae: A Bioinformatic Approach
Authors: Akter Zakia , Haque Anamul , Hossain Md. Sabir , Ahmed Firoz , Islam Md Asiful 
Published: January 2020

Background:
Cholera, a diarrheal illness, causes millions of deaths worldwide due to
large outbreaks. The monoclonal antibody used as therapeutic purposes of cholera is prone to be
unstable due to various factors including self-aggregation.

Objectives:
In this bioinformatic analysis, we identified the aggregation prone regions (APRs) of
antibody sequences of different immunogens (i.e., CTB, ZnM-CTB, ZnP-CTB, TcpA-CT-CTB,
ZnM-TcpA-CT-CTB, ZnP-TcpA-CT-CTB, ZnM-TcpA, ZnP-TcpA, TcpA-CT-TcpA, ZnM-TcpACT-
TcpA, ZnP-TcpA-CT-TcpA, Ogawa, Inaba and ZnM-Inaba) raised against Vibrio cholerae.

Methods:
To determine APRs in antibody sequences that were generated after immunizing Vibrio
cholerae immunogens on Mus musculus, a total of 94 sequences were downloaded as FASTA
format from a protein database and the algorithms such as Tango, Waltz, PASTA 2.0, and
AGGRESCAN were followed to analyze probable APRs in all of the sequences.

Results:
A remarkably high number of regions in the monoclonal antibodies were identified to be
APRs which could explain a cause of instability/short term protection of the anticholera vaccine.

Conclusion:
To increase the stability, it would be interesting to eliminate the APR residues from
the therapeutic antibodies in such a way that the antigen-binding sites or the complementarity
determining region loops involved in antigen recognition are not disrupted.
Implementasi Tujuan Jangka Menengah Dan Jangka Panjang Proyek Perubahan Oleh Camat Alumni Diklat Kepemimpinan Tingkat III di Kota Jambi
Authors: Bailah Bailah 
Published: January 2020

Penelitian ini dilatarbelakangi keinginan untuk mengetahui sejauh mana implementasi tujuan jangka menengah dan tujan jangka panjang proyek perubahan oleh alumni Diklat Kepemimpinan Tingkat III Pola Baru yang sudah diterapkan sejak pertengahan 2014 oleh Lembaga Administrasi Negara RI. Tujuan penelitian ini ialah untuk mendeskripsikan faktor-faktor yang mempengaruhi implementasi proyek perubahan oleh para pejabat yang bertanggungjawab terhadap pengelolaan program di instansinya. Teori yang digunakan dalam penelitian ini adalah teori implementasi Merilee S. Grindle yang menyatakan bahwa implementasi dipengaruhi oleh dua variabel besar, yakni isi kebijakan dan lingkungan kebijakan. Metode yang digunakan dalam penelitian ini ialah kualitatif deskriptif dengan data primer dan sekunder yang diperoleh melalui wawancara mendalam, observasi dan studi dokumentasi. Informan ditentukan dengan purposive sampling, yakni para Camat Alumni Diklat Kepemimpinan Tingkat III sebagai pengelola program, para pelaksana dan pemanfaat program. Triangulasi data dilakukan dengan metode triangulasi sumber. Hasil penelitian ini menunjukan bahwa implementasi tujuan jangka menengah proyek perubahan sudah berjalan baik dan sesuai dengan yang ditargetkan dan implementasi tujuan jangka panjang proyek perubahan juga berjalan baik dan sesuai dengan tujuannya. Walaupun demikan, perlu dilakukan penyempurnaan dalam beberapa aspek teknis impelementasi, seperti keterkaitan pihak ketiga dengan implementasi dan kemampuan mengikuti perkembangan teknologi informasi
Optimasi Tingkat Layanan Call Center Jasa Teleponi Dasar: Kajian Regulasi
Authors: Purwadi Hendro 
Published: January 2020

Service level in the call center is calculated based on the number of calls answered during the certain time intervals compared to the total number of calls received. The measurement of service level on the call center operator starts when the caller presses the menu to talk to the operator on interactive voice response (IVR) menu, and is expressed as a percentage. The higher expected percentage of service level will be higher the needs of operator in the services. Regulation in Indonesia determines service level for the call center of Basic Telephony Services is in the amount of more than or equal to 90% in 30 seconds. The author uses a business approach to the operational of the call center to analyze existing statutory data. Through the comparative method between operator occupancy and the costs required for the operation of call center using supply and demand curve, the optimum service level value at the call center of Basic Telephony Services can be known, which is 85% in 25 seconds. This means that 85% of incoming calls must be answered by the operator with a maximum waiting time of 25 seconds.
KOMUNIKASI POLITIK POLRI PADA ERA REFORMASI
Authors: Shinta Dewi Evie Ariadne 
Published: January 2020

Abstract
The topic of this article attempts to examine the Indonesian National Police from the perspective of Political Communication with the proposition that although the police are a law enforcement agency, its performance -through communications activities- can have sociological and political influence both locally, nationally and even regional and global. Moreover, if it refers to Peter Berger & Thomas Luckmann's idea where reality is built socially, then the performance of the Police is in line with its core tasks because it creates public order and safeguards is not articulated in a vacuum circumstances, but in the midst of an active society and dynamic. It is what the meant as sociological and political aspects. It’s a Qualitative descriptive study with desk research type which data collected using various sources in the form of documentation studies both hard copy and soft copy obtained in the library or online media. The analysis is done by using political communication concepts. The results of the study show that: firstly, the police institution in the context of social politics has the role of democracy guardian, secondly, police institutions are required to build harmonious political communications with other state institutions, especially with the House of Representatives (DPR) and the Corruption Eradication Commission (Komisi Pemberantasan Korupsi) KPK), and the third is police institutions are required to maintain the positive image of the institution by improving and improving the quality of Human Resources (HR) and enforcement of the integrity of the apparatus.
Data and Obstacle: Police (Non)Visibility in Research on Protest Policing
Authors: Ullrich Peter 
Published: January 2020

The police, in particular the riot police, can be a rather inaccessible object of investigation, whose reservations towards research are analysed with reference to five barriers: 1) police control of access to the field, 2) the doubly asymmetric research relationship, 3) attempts by the police to steer the process, 4) the sceptical attitude of (potential) interviewees, and 5) the restrained discussion behaviour. However, what appears as a hurdle from a researcher’s perspective allows structures of the object itself to be reconstructed. These include a prevalence of narratives of police “innocence” and “powerlessness” with which resistance against external aspirations for control is buttressed. The police view themselves as constantly being under public scrutiny and being unjustly publicly criticised. In this manner the predominant attitude towards research is reserved if not hostile. The police definitional power in its fields of action is thus partially transferred to research on the police. However, police interference has its limits, and counterstrategies will be set forth. Most data used are from a grounded theory methodology (GTM) project on video surveillance and countersurveillance of demonstrations, based primarily on group discussions and expert interviews with riot police.
Effectiveness of Cervical Spine High-Velocity, Low-Amplitude Thrust Added to Behavioral Education, Soft Tissue Mobilization, and Exercise for People With Temporomandibular Disorder With Myalgia: A Randomized Clinical Trial
Authors: Reynolds Breanna , Puentedura Emilio J. , Kolber Morey J. , Cleland Joshua A. 
Published: January 2020

Objective To determine the immediate and short-term effects of adding cervical spine high-velocity, low-amplitude thrust (HVLAT) to behavioral education, soft tissue mobilization, and a home exercise program on pain and dysfunction for people with a primary complaint of temporomandibular disorder (TMD) with myalgia. Design Randomized clinical trial. Methods Fifty individuals with TMD were randomly assigned to receive cervical HVLAT or sham manipulation for 4 visits over 4 weeks. Participants in both groups received other treatments, including standardized behavioral education, soft tissue mobilization, and a home exercise program. Primary outcomes included maximal mouth opening, the numeric pain-rating scale, the Jaw Functional Limitation Scale (JFLS), the Tampa Scale of Kinesiophobia for TMD (TSK-TMD), and a global rating of change (GROC). Self-report and objective measurements were taken at baseline, immediately after initial treatment, and follow-ups of 1 week and 4 weeks. A 2-by-4 mixed-model analysis of variance was used, with intervention group as the between-subjects factor and time as the within-subject factor. Separate analyses of variance were performed for dependent variables, and the hypothesis of interest was the group-by-time interaction. Results There was no significant interaction for maximal mouth opening, the numeric pain-rating scale, or secondary measures. There were significant 2-way interactions for the JFLS (d = 0.60) and TSK-TMD (d = 0.80). The HVLAT group had lower fear at 4 weeks and improved jaw function earlier (1 week). The GROC favored the HVLAT group, with significant differences in successful outcomes noted immediately after baseline treatment (thrust, 6/25; sham, 0/25) and at 4 weeks (thrust, 17/25; sham, 10/25). Conclusion Both groups improved over time; however, differences between groups were small. There were significant differences between groups for the JFLS, TSK-TMD, and GROC. The additive clinical effect of cervical HVLAT to standard care remains unclear for treating TMD. J Orthop Sports Phys Ther 2020;50(8):455–465. Epub 6 Jan 2020. doi:10.2519/jospt.2020.9175
Stability studies of hydralazine hydrochloride orodispersible formulations
Authors: Muthukumar  , Sundaraganapathy R  , Sankar C  , Sundaramoorthy C  , Yuvaraja K R  
Published: January 2020

Solid dosage forms also have a impervious difficulties in patients especially for geriatric and paediatric patients.Dysphagia is common among all age groups. Orodispersible formulations (Fast dissolving tablets & Fast dissolving oral thin films) constitute an inventive dosage form that overcome the problems swallowing and provides speedy onset of action. The objective of present study was to formulate orodispersible formulations of Hydralazine HCL by different methods (Direct compression method, Sublimation method and solvent casting method). Based on physiochemical evaluations F9 (Direct compression method),SF9 (Sublimation method) for Fast dissolving tablets and H2 formulations (Solvent casting method) for Fast dissolving oral thin films were found optimized formula.The optimized formula were kept for stability under long term, accelerated and intermediate conditions for the study period of six months as per ICH guidelines.Based on stability reports the H2 formulations (Fast dissolving oral thin films) got a better drug release than Fast dissolving tablets.
BIOSAFETY MEASURES ADOPTED BY NURSING UNDERGRADUATES IN DAILY ACTIVITIES IN SPACES OF LABORATORY PRACTICES
Authors: Ribeiro Ivonizete Pires , Oliveira Elizana Carvalho , Silva Jessyca Samara de Sampaio , Carvalho Herica Emilia Félix de 
Published: January 2020

Objective: to analyze the biosafety measures adopted by nursing undergraduates in daily activities in spaces of laboratory practices.Method: descriptive, qualitative analysis study performed at a Higher Education Institution in the period from April to June 2018, with 30 students. For the analyses of interviews, Collective Subject Discourse was utilized. Results: as for Personal Protective Equipment (PPE) usage, 24% used gloves, followed by white coat and mask, with 19% and 18% each, respectively. Referring to moments of Hand Hygiene (HH) during the laboratory practices, 32% performed the hygiene before and 26% after the practice. It is observed that the scholars’ knowledge about biosafety is broad but limited to PPE usage. Conclusion: it is verified that the use of biosafety measures in this environment is still a challenge, for it be limited to PPE and HH usage.