bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solar Power Development: A Root for Sustainable Development of India
Authors: Mausam Kuwar , Kumar Ghosh Subrata , Tiwari Arun kumar , Singh Ravindra P. 
Published: December 2019

Abstract
Sustainable development of second most populated country of world, India depends on the planning and utilization of conventional and non-conventional energy sources. Presently energy safety has top most prime concerned for sustainable development. Energy barriers/bottleneck, prospect of solar energy with consideration of cost, hot spot of solar energy, government policies, training and education of solar sector and data of solar radiation analyze in this article. Key aspect that helpful in barrier reduction and growth of solar sector suggested through paper. By this study it has been found that sustainable growth of India depend of utilization of solar energy. Full concentration by country over solar sector necessary for satisfying future demand of energy for country growth and development.
Gate-tunable flat bands in van der Waals patterned dielectric superlattices
Authors: Shi Li-kun , Ma Jing , Song Justin C W 
Published: December 2019

Abstract
Superlattice engineering provides the means to reshape the fabric felt by quasiparticles moving in a material. Here we argue that bandstructure engineering with superlattices can be pushed to the extreme limit by stacking gapped van der Waals (vdW) materials on patterned dielectric substrates. Specifically, we find that high quality vdW patterned dielectric superlattices (PDS) realize a series of robust flat bands that can be directly switched on and off by gate voltage in situ. In contrast to existing superlattice platforms, these flat bands are realized without the need for fine tuning. Instead, the bands become flat as the gate voltage increases in magnitude. The characteristics of PDS flatbands are highly tunable: the type of flatband (single non-degenerate or dirac-cone-like), localization length, and interaction energy are sensitive to the applied gate voltage. As a result, electron-electron interactions in the PDS flatbands can become stronger than both the bandwidth and disorder broadening, providing a setting for correlated behavior such as flatband ferromagnetism. We expect PDS flatbands can be experimentally realized in a range of readily available gapped vdW materials such as monolayer transition metal dichalcogenides, e.g. WSe2.
Fast-track hip and knee arthroplasty in older adults—a prospective cohort of 1,427 procedures in patients ≥85 years
Authors: Petersen Pelle Baggesgaard , Jørgensen Christoffer Calov , Kehlet Henrik ,   Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group
Published: December 2019

ABSTRACT

Introduction
fast-track protocols in total hip and knee arthroplasty (THA/TKA) have improved postoperative recovery and reduced postoperative morbidity. Additionally, increasing life expectancy and improved surgical techniques have led to an increasing number of older adult patients undergoing THA/TKA. However, no large detailed studies on fast-track THA/TKA in older adults are available. Consequently, we aimed to describe the length of stay (LOS) and postoperative morbidity in a large cohort of patients ≥85 years within a continuous multicentre fast-track collaboration.

Methods
we used a prospective observational cohort design with unselected consecutive data between 2010 and 2017 on primary elective THA and TKA patients ≥85 years. Data were obtained from nine centres reporting to the Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement database and the Danish National Patient Registry on LOS, readmissions and mortality. Causes of morbidity were determined by review of health records.

Results
we included 1,427 (3.9% of all THA/TKA) procedures with 62.3% THA. Median age was 87 (IQR: 85–88) years with 71% women. LOS decreased from median 4 (3–6) days in 2010 to 2 (2–3) days in 2017. The proportion with LOS &gt; 4 days decreased from 32 to 18%. Readmission and mortality rate remained at about 11.7 and 0.9% after 30 days and 16.0 and 1.5% after 90 days, respectively.

Conclusion
this detailed large multicentre fast-track THA/TKA study in patients ≥85 years found major reductions in LOS without increase in readmission or mortality rates. The unchanged readmission rate poses an area for further improvements.
Factors associated with self- and informant ratings of quality of life, well-being and life satisfaction in people with mild-to-moderate dementia: results from the Improving the experience of Dementia and Enhancing Active Life programme
Authors: Wu Yu-Tzu , Nelis Sharon M , Quinn Catherine , Martyr Anthony , Jones Ian R , Victor Christina R , Knapp Martin , Henderson Catherine , Hindle John V , Jones Roy W , Kopelman Michael D , Morris Robin G , Pickett James A , Rusted Jennifer M , Thom Jeanette M , Litherland Rachael , Matthews Fiona E , Clare Linda ,   the IDEAL Programme team
Published: December 2019

Abstract

Background
a large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementia symptoms. The aim of this study is to compare self- and informant-rated quality of life, life satisfaction and well-being, and investigate the relationships of the two different rating methods with various social, psychological and health factors, using a large cohort study of community-dwelling people with dementia and carers in Great Britain.

Methods
this study included 1,283 dyads of people with mild-to-moderate dementia and their primary carers in the Improving the experience of Dementia and Enhancing Active Life study. Multivariate modelling was used to investigate associations of self- and informant-rated quality of life, life satisfaction and well-being with factors in five domains: psychological characteristics and health; social location; capitals, assets and resources; physical fitness and health; and managing everyday life with dementia.

Results
people with dementia rated their quality of life, life satisfaction and well-being more highly than did the informants. Despite these differences, the two approaches had similar relationships with social, psychological and physical health factors in the five domains.

Conclusion
although self- and informant ratings differ, they display similar results when focusing on factors associated with quality of life, life satisfaction and well-being. Either self- or informant ratings may offer a reasonable source of information about people with dementia in terms of understanding associated factors.
Invited Commentary: Relationship Between Ovulation and Markers of Systemic Inflammation Versus Markers of Localized Inflammation
Authors: Schildkraut Joellen M 
Published: December 2019

AbstractIn this issue of the American Journal of Epidemiology, Huang et al. (Am J Epidemiol. 2020;189(7):660–670) report an inverse relationship between lifetime ovulatory years (LOY) and circulating levels of C-reactive protein (CRP), counter to their hypothesis. CRP is a nonspecific systemic marker of chronic inflammation, and there is evidence that there are other drivers of systemic inflammation as measured by CRP. There also is a body of evidence supporting the possibility that ovulation may be responsible for a localized inflammatory response. Because ovarian cancer is the fifth most common cause of cancer death in women, preventive strategies are urgently needed. The findings of this report underscore the need for new research initiatives to determine the relationship between incessant ovulation and ovarian cancer risk in order to identify mechanisms of carcinogenesis.
Exposure Determinants of Wood Dust, Microbial Components, Resin Acids and Terpenes in the Saw- and Planer Mill Industry
Authors: Straumfors Anne , Corbin Marine , McLean Dave , ‘t Mannetje Andrea , Olsen Raymond , Afanou Anani , Daae Hanne-Line , Skare Øivind , Ulvestad Bente , Laier Johnsen Helle , Eduard Wijnand , Douwes Jeroen 
Published: December 2019

Abstract

Objectives
Sawmill workers have an increased risk of adverse respiratory outcomes, but knowledge about exposure–response relationships is incomplete. The objective of this study was to assess exposure determinants of dust, microbial components, resin acids, and terpenes in sawmills processing pine and spruce, to guide the development of department and task-based exposure prediction models.

Methods
2474 full-shift repeated personal airborne measurements of dust, resin acids, fungal spores and fragments, endotoxins, mono-, and sesquiterpenes were conducted in 10 departments of 11 saw- and planer mills in Norway in 2013–2016. Department and task-based exposure determinants were identified and geometric mean ratios (GMRs) estimated using mixed model regression. The effects of season and wood type were also studied.

Results
The exposure ratio of individual components was similar in many of the departments. Nonetheless, the highest microbial and monoterpene exposure (expressed per hour) were estimated in the green part of the sawmills: endotoxins [GMR (95% confidence interval) 1.2 (1.0–1.3)], fungal spores [1.1 (1.0–1.2)], and monoterpenes [1.3 (1.1–1.4)]. The highest resin acid GMR was estimated in the dry part of the sawmills [1.4 (1.2–1.5)]. Season and wood type had a large effect on the estimated exposure. In particular, summer and spruce were strong determinants of increased exposure to endotoxin (GMRs [4.6 (3.5–6.2)] and [2.0 (1.4–3.0)], respectively) and fungal spores (GMRs [2.2 (1.7–2.8)] and [1.5 (1.0–2.1)], respectively). Pine was a strong determinant for increased exposure to both resin acid and monoterpenes. Work as a boilerman was associated with moderate to relatively high exposure to all components [1.0–1.4 (0.8–2.0)], although the estimates were based on 13–15 samples only. Cleaning in the saw, planer, and sorting of dry timber departments was associated with high exposure estimates for several components, whereas work with transportation and stock/finished goods were associated with low exposure estimates for all components. The department-based models explained 21–61% of the total exposure variances, 0–90% of the between worker (BW) variance, and 1–36% of the within worker (WW) variances. The task-based models explained 22–62% of the total variance, 0–91% of the BW variance, and 0–33% of the WW variance.

Conclusions
Exposure determinants in sawmills including department, task, season, and wood type differed for individual components, and explained a relatively large proportion of the total variances. Application of department/task-based exposure prediction models for specific exposures will therefore likely improve the assessment of exposure–response associations.
Great spotted cuckoos show dynamic patterns of host selection during the breeding season. The importance of laying stage and parasitism status of magpie nests
Authors: Soler Manuel , Pérez-Contreras Tomás , Soler Juan José 
Published: December 2019

AbstractAvian brood parasites depend entirely on their hosts to raise their nestlings until independence. Thus, parasite females should select suitable host nests for egg laying according to traits that enhance offspring survival. The availability of nests of certain characteristics influencing the survival of parasitic offspring is, however, temporally dynamic and, thus, patterns of host selection should be evaluated considering characteristics of available host nests the day of parasitism. This allows detecting possible seasonal changes and, therefore, a more realistic picture of host selection by brood parasites. In this paper, we adopt such a new approach and consider daily availability of magpie (Pica pica) host nests at different breeding stage that were or were not parasitized by the great spotted cuckoo (Clamator glandarius). Theory predicts that cuckoos should select host nests at the laying stage. Accordingly, we detected that cuckoos preferred to parasitize magpie nests at the laying stage but, mainly, those that already harbored one or two cuckoo eggs, which may seem counterintuitive. We also showed that patterns of host selection by cuckoos varied during the breeding season, which implies that brood parasite–host interaction is dynamic depending on phenology. These patterns are hidden when not considering the temporally dynamic nature of the availability of host nests of characteristics of interest. We discuss the importance of such patterns and considering diary hosts nests availability for detecting them.
Does the response of D. melanogaster males to intrasexual competitors influence sexual isolation?
Authors: Marie-Orleach Lucas , Sanz Annui M , Bailey Nathan W , Ritchie Michael G 
Published: December 2019

AbstractThe evolutionary consequences of phenotypic plasticity are debated. For example, reproductive barriers between incipient species can depend on the social environment, but most evidence for this comes from studies focusing on the effects of experiencing heterospecific individuals of the opposite sex. In Drosophila melanogaster, males are well known to invest strategically in ejaculate components and show different courtship behavior when reared in the presence of male competitors. It is unknown whether such plasticity in response to same-sex social experience influences sexual isolation, so we tested this using African and cosmopolitan lines, which show partial sexual isolation. Males were housed in social isolation, with homopopulation, or with heteropopulation male partners. We then measured their mating success, latency, and duration, their paternity share, and female remating success. Isolated males copulated for a shorter duration than males housed with any male partners. However, we found no difference in any measure between homopopulation or heteropopulation treatments. Our findings suggest that the male intrasexual competitive social environment does not strongly influence sexual isolation in D. melanogaster, and that plastic effects on reproductive isolation may be influenced more strongly by the experience of social isolation than by the composition of individuals within different social environments.
Cotrimoxazole Prophylaxis Increases Resistance Gene Prevalence and α-Diversity but Decreases β-Diversity in the Gut Microbiome of Human Immunodeficiency Virus–Exposed, Uninfected Infants
Authors: D’Souza Alaric W , Moodley-Govender Eshia , Berla Bertram , Kelkar Tejas , Wang Bin , Sun Xiaoqing , Daniels Brodie , Coutsoudis Anna , Trehan Indi , Dantas Gautam 
Published: December 2019

AbstractBackgroundProphylactic cotrimoxazole treatment is recommended in human immunodeficiency virus (HIV)–exposed, uninfected (HEU) infants, but the effects of this treatment on developing HEU infant gut microbiotas and resistomes are largely undefined.MethodsWe analyzed whole-metagenome sequencing data from 163 longitudinally collected stool samples from 63 HEU infants randomized to receive (n = 34; CTX-T) or to not receive (n = 29; CTX-N) prophylactic cotrimoxazole treatment. We generated taxonomic, functional pathway, and resistance gene profiles for each sample and compared microbiome signatures between the CTX-T and CTX-N infants.ResultsMetagenomic analysis did not reveal significant differences in taxonomic or functional pathway α-diversity between CTX-T and CTX-N infants. In contrast, resistance gene prevalence (P = .00719) and α-diversity (P = .0045) increased in CTX-T infants. These differences increased over time for both resistance gene prevalence measured by log-normalized abundance (4-month mean, 0.71 [95% confidence interval {CI}, .2–1.2] and 6-month mean, 0.85 [95% CI, .1–1.7]) and α-diversity (P = .0045). Unlike α-diversity, interindividual gut microbiome taxonomic (mean, −0.11 [95% CI, −.15 to −.077]), functional taxonomic (mean, −0.050 [95% CI, −.084 to −.017]), and resistance gene (mean, −0.13 [95% CI, −.17 to −.099]) β-diversity decreased in CTX-T infants compared with CTX-N infants. These results are consistent with persistent antibiotic selection pressure.ConclusionsCotrimoxazole prophylaxis in HEU infants decreased gut microbiome β-diversity and increased antibiotic resistance gene α-diversity and prevalence. Antibiotic resistance is a growing threat, especially in low- and middle-income countries where the higher perinatal HIV exposure rates result in cotrimoxazole prophylaxis. Understanding effects from current HEU infant antibiotic prophylaxis guidelines will inform guideline revisions and efforts to reduce increasing antibiotic resistance.
Extreme temperature combined with hypoxia, affects swimming performance in brown trout (Salmo trutta)
Authors: Nudds Robert L , Ozolina Karlina , Fenkes Miriam , Wearing Oliver H , Shiels Holly A 
Published: December 2019

AbstractClimate change is predicted to impact freshwater aquatic environments through changes to water temperature (Twater), river flow and eutrophication. Riverine habitats contain many economically and ecologically important fishes. One such group is the migratory salmonids, which are sensitive to warm Twater and low O2 (hypoxia). While several studies have investigated the independent effects of Twater and hypoxia on fish physiology, the combined effects of these stressors is less well known. Furthermore, no study has investigated the effects of Twater and O2 saturation levels within the range currently experienced by a salmonid species. Thus, the aim of this study was to investigate the simultaneous effects of Twater and O2 saturation level on the energetics and kinematics of steady-state swimming in brown trout, Salmo trutta. No effect of O2 saturation level (70 and 100% air saturation) on tail-beat kinematics was detected. Conversely, Twater (10, 14, 18 and 22°C) did affect tail-beat kinematics, but a trade-off between frequency (ftail) and amplitude (A, maximum tail excursion) maintained the Strouhal number (St = ftail• A/U, where U is swimming speed) within the theoretically most mechanically efficient range. Swimming oxygen consumption rate (${\dot{M}}_{{\mathsf{O}}_{\mathsf{2}}}$) and cost of transport increased with both U and Twater. The only effect of O2 saturation level was observed at the highest Twater (22°C) and fastest swimming speed (two speeds were used—0.6 and 0.8 m s−1). As the extremes of this study are consistent with current summer conditions in parts of UK waterways, our findings may indicate that S. trutta will be negatively impacted by the increased Twater and reduced O2 levels likely presented by anthropogenic climate change.
Septal contraction predicts acute haemodynamic improvement and paced QRS width reduction in cardiac resynchronization therapy
Authors: Ross Stian , Nestaas Eirik , Kongsgaard Erik , Odland Hans H , Haland Trine F , Hopp Einar , Haugaa Kristina H , Edvardsen Thor 
Published: December 2019

Abstract

Aims
Three distinct septal contraction patterns typical for left bundle branch block may be assessed using echocardiography in heart failure patients scheduled for cardiac resynchronization therapy (CRT). The aim of this study was to explore the association between these septal contraction patterns and the acute haemodynamic and electrical response to biventricular pacing (BIVP) in patients undergoing CRT implantation.

Methods and results
Thirty-eight CRT candidates underwent speckle tracking echocardiography prior to device implantation. The patients were divided into two groups based on whether their septal contraction pattern was indicative of dyssynchrony (premature septal contraction followed by various amount of stretch) or not (normally timed septal contraction with minimal stretch). CRT implantation was performed under invasive left ventricular (LV) pressure monitoring and we defined acute CRT response as ≥10% increase in LV dP/dtmax. End-diastolic pressure (EDP) and QRS width served as a diastolic and electrical parameter, respectively. LV dP/dtmax improved under BIVP (737 ± 177 mmHg/s vs. 838 ± 199 mmHg/s, P &lt; 0.001) and 26 patients (68%) were defined as acute CRT responders. Patients with premature septal contraction (n = 27) experienced acute improvement in systolic (ΔdP/dtmax: 18.3 ± 8.9%, P &lt; 0.001), diastolic (ΔEDP: −30.6 ± 29.9%, P &lt; 0.001) and electrical (ΔQRS width: −23.3 ± 13.2%, P &lt; 0.001) parameters. No improvement under BIVP was observed in patients (n = 11) with normally timed septal contraction (ΔdP/dtmax: 4.0 ± 7.8%, P = 0.12; ΔEDP: −8.8 ± 38.4%, P = 0.47 and ΔQRS width: −0.9 ± 11.4%, P = 0.79).

Conclusion
Septal contraction patterns are an excellent predictor of acute CRT response. Only patients with premature septal contraction experienced acute systolic, diastolic, and electrical improvement under BIVP.
Predictors of post-thymectomy long-term neurological remission in thymomatous myasthenia gravis: an analysis from a multi-institutional database
Authors: Na Kwon Joong , Hyun Kwanyong , Kang Chang Hyun , Park Samina , Lee Hyun Joo , Park In Kyu , Kim Young Tae , Lee Geun Dong , Kim Hyeong Ryul , Choi Se Hoon , Kim Yong-Hee , Kim Dong Kwan , Park Seung-Il , Shin Sumin , Cho Jong Ho , Kim Hong Kwan , Choi Yong Soo , Kim Jhingook , Zo Jae Il , Shim Young Mog , Lee Chang Young , Lee Jin Gu , Kim Dae Joon , Paik Hyo Chae , Chung Kyung Young 
Published: December 2019

Abstract

OBJECTIVES
Thymectomy is the treatment of choice for thymomatous myasthenia gravis (MG) for both oncological and neurological aspects. However, only a few studies comprising small numbers of patients have investigated post-thymectomy neurological outcomes. We examined post-thymectomy long-term neurological outcomes and predictors of thymomatous MG using a multi-institutional database.

METHODS
In total, 193 patients (47.3 ± 12.0 years; male:female = 90:103) with surgically resected thymomatous MG between 2000 and 2013 were included. Complete stable remission (CSR) and composite neurological remission (CNR), defined as the achievement of CSR and pharmacological remission after thymectomy, were evaluated. Predictors for CSR and CNR were examined by Cox regression analysis.

RESULTS
The median duration between MG and thymectomy was 3.1 months. In addition, 161 patients (83.4%) had symptoms less than Myasthenia Gravis Foundation of America clinical classification III. All patients underwent an extended thymectomy; there were no perioperative deaths. The 10-year cumulative probability of CSR and CNR was 36.9% and 69.1%, respectively. Mild preoperative symptoms were a significant predictor for CSR (P = 0.040), and a large tumour was a predictor for CNR (P &lt; 0.001). Patients with a large tumour were associated with early MG onset and no steroid treatment. Surgical methods, thymoma stage and histological subtypes were not associated with long-term neurological remission.

CONCLUSIONS
Large tumour size and preoperative mild symptoms were predictors for long-term neurological outcome in thymomatous MG. Considering that patients with early onset of MG and no immunosuppressive treatment tend to have large tumours, early surgical intervention for patients with thymomatous MG having mild symptoms might be beneficial for controlling neurological outcomes.