bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIMINASI TEKNOLOGI BUDIDAYA PADI FUNGSIONAL BERAS MERAH DAN HITAM PADA KELOMPOK TANI KELAPA GADING DESA KEBUN AYU KECAMATAN GERUNG KABUPATEN LOMBOK BARAT
Authors: Aryana I G usti Putu Muliarta , Sudika I Wayan , Sudhramawan Anak Agung Ketut , Suliartini Ni Wayan Sri , Wideratih Anggun Angling , Sudhanta I Made 
Published: December 2024

Dalam rangka mempertahankan Nusa Tenggara Barat sebagai salah satu lumbung beras nasional dan ikut serta dalam mempertahankan swasembada beras secara nasional maka perlu kira memperkenalkan teknologi budidaya dan varietas unggul padi beras merah dan beras hitam serta memperdayakan kelompok-kelompok tani yang ada dipedesaan sebagai pelaksana teknologi budididaya yang benar dan terpadu.Permasalahan yang dijumpai pada kelompok tani Kelapa Gading di desa Kebun Ayu kecamatan Gerung kabupaten Lombok Barat adalah belum mengenal tentang padi beras Merah dan beras hitam baik tentang manfaat maupun teknologi budidaya. Dari hasil kegiatan ini target khusus yang akan dihasilkan peningkatan pengetahuan, pemahaman tentang padi beras merah dan hitam; pemanfaatnya sebagai padi fungsional, serta keterampilan dalam penerapan teknologi budidaya melalui sistim tanam jajar Legowo 4:1 dengan menggunakan umur bibit muda 18 hari. sehingga di hasilkan petingkatan produksi padi beras merah sebesar 10-15 %.. Metode yang digunakan pada program ini adalah metode pelatihanan yang dilanjutkan dengan kerja praktik di lapang dan kaji tindak partisifatif aktif (partisipatori action research) di lapang secara aktif sejak persiapan hingga evaluasi melibatkan mahasiswa KKN. Kegiatan ini di laksanakan mulai Januari – April 2024. Tahapan kegiatan meliputi diberikan diklat selama 1 hari dan praktik laboratorium lapang (Demplot) tentang tanam jajar legowo 4:1, penggunaan umur bibit optimum pada luasan lahan 15 are. Pemberian materi dilakukan oleh tim penyuluh serta mitra dari Saprotan utama tekait dengan penggungunaan pupuk dan pestisida. Evaluasi untuk mengukur keberhasilan kegiatan ini dilakukan melalui respon peserta pada saat penyampai teori/diklat, respon peserta pada saat pelaksanaan praktek lapang. Pengamatan pada petak laboratorium lapang. Hasil kegiatan menunjukkan, bahwa Anggota kelompok tani Kelapa Gading desa Kebun Ayu Gerung Lombok Barat melalui kegiatan penyuluhan telah paham tentang deskripsi padi beras hitam dan merah, paham akan kandungan dan manfaatnya beras hitam maupun merah bagi kesehatan, serta paham akan teknologi budidaya baik pada padi beras hitam maupun merah dengan pola Jajar Legowo 4:1.Melalui kegiatan demplot dan pendampingan para petani mampu mempraktikan budidaya padi beras hitam dan merah mulai perendaman benih, pembibitan, penanaman hingga panen.
STRATEGIC APPROACHES TO ATTRACTING INVESTMENT IN RURAL AREA DEVELOPMENT
Authors: Nepochatenko Olena , Verniuk Nataliia , Movchaniuk Anastasiia 
Published: December 2024

The article discusses strategic approaches to attracting investment in the development of rural areas. It is emphasized that in contemporary conditions, key aspects are becoming economic stability, efficient resource utilization, ensuring food security, and social protection of the population. It is established that the development of rural areas depends on the efficiency of economic activity of agricultural enterprises located in these areas.
A thorough analysis of the dynamics of capital investments in the Ukrainian economy and agricultural sector has revealed the need to develop conceptual approaches for defining the strategic foundations of investment provision as a complex economic process. It has been argued that attracting investments, both domestic and foreign, is essential for the comprehensive development of rural areas and the agricultural sector. Such investments would contribute to modernizing agricultural production, improving its efficiency, expanding infrastructure, and stimulating job creation. Given this context, there is a pressing need for innovative strategies to attract investments for rural development. These strategies should adopt an integrated approach that addresses economic, infrastructure, and social dimensions, fostering the sustainable development of the agricultural sector as a cornerstone of Ukraine’s economic revitalization.
It is evident that the successful implementation of strategic rural development initiatives necessitates a comprehensive approach involving active participation from government agencies, local authorities, agricultural businesses, and rural communities. A conceptual framework for managing financial flows within logistics systems will contribute to crisis prevention, improved operational efficiency, and the overall growth of the sector.
Bilateral vocal cord paralysis following ventriculoatrial shunt placement for hydrocephalus after subarachnoid hemorrhage: illustrative case
Authors: Ikeda Kensuke , Fujii Shoko , Maruyama Keisuke , Yoshida Hiroki , Seiya Yosuke , Takahashi Shoichi , Kagiwata Hiroki , Nagai Jun , Onoda Ryo , Okada Kei , Noguchi Akio , Nakatomi Hirofumi 
Published: December 2024

BACKGROUND
A ventriculoatrial (VA) shunt is an alternative to a ventriculoperitoneal (VP) shunt for managing hydrocephalus, especially when VP shunt insertion is not feasible. Despite its decline in use, the VA shunt remains vital for certain patients. This report highlights a rare complication of bilateral vocal cord paralysis following VA shunt insertion for hydrocephalus secondary to subarachnoid hemorrhage.

OBSERVATIONS
A woman in her 60s with a history of hypertension and giant liver cysts developed hydrocephalus after a subarachnoid hemorrhage. Because of her abdominal anatomical problems, VA shunt insertion assisted by transesophageal echocardiography (TEE) was chosen. Postoperatively, she experienced sudden dyspnea and upper airway stridor, diagnosed as bilateral vocal cord paralysis, necessitating an emergency tracheostomy. Gradual improvement was noted over the following month.

LESSONS
Bilateral vocal cord paralysis can be a potential complication of TEE-assisted VA shunt procedures. To mitigate this risk, preoperative assessments of vocal cord function and swallowing are recommended. Alternatives to TEE, such as fluoroscopy or smaller probes, can be considered for patients with risk factors, including severe subarachnoid hemorrhage and prolonged intubation.
https://thejns.org/doi/10.3171/CASE24518
ASSESSMENT OF MORTALITY RISKS FROM COVID-19 IN HOSPITALISED VACCINATED PATIENTS AND PATIENTS AFTER A PREVIOUS ILLNESS DEPENDING ON AGE
Authors: Riaba O.V. , Golubovska O.A. , Chalyy K.O. 
Published: December 2024

Background. According to numerous studies, vaccination is an effective method in preventing hospitalisation and mortality from COVID-19. However, COVID-19-related deaths have also been reported among fully vaccinated individuals.
Aim: to compare the risks of mortality from coronavirus disease 2019 in hospitalised vaccinated patients and patients who have not been vaccinated before after a previous illness of different sexes and different age groups.
Materials and methods. the study included 220 hospitalised patients who were divided into two groups: vaccinated patients (n=129) and patients with a history of COVID-19 (n=91). All patients were divided into three groups by age: ≤39 years, 40-69 years, ≥70 years. All patients were admitted with laboratory-confirmed SARS-CoV-2 by PCR or a rapid qualitative antigen test.
Results. in the age group ≤39 years, no deaths from COVID-19 were recorded. When comparing the incidence of deaths among hospitalised patients after a previous illness (n=36) and vaccinated patients (n=58) in the age group 40-69 years, no statistically significant risk difference was found (p=0.742). The risks of mortality among hospitalised patients with a history of COVID-19 (n=46) and vaccinated patients (n=58) in the age group ≥70 years were statistically significantly different (p=0.011). At the same time, the risk in patients after a previous illness was 22.3% higher than in the vaccinated group (95%CI 6.5-37.7).
Implementasi Ruang Ilmiah dalam Perspektif Teori Humanistik pada Pembelajaran Jarak Jauh Mahasiswa Sentra Layanan Universitas Terbuka (SALUT) Kota Batu
Authors: Batti Steviani , Ginting Andi Lopa , Suwarno Asmawati 
Published: December 2024

Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui terkait ruang ilmiah yang diciptakan oleh Universitas Terbuka Salut Kota Batu bagi mahasiswa dengan mekanisme pembelajaran jarak jauh dalam perspektif teori humanistik. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Lokasi yang dipilih dalam penelitian ini adalah di Sentra Layanan Universitas Terbuka Kota Batu. Data yang digunakan dalam penelitian ini didapatkan melalui wawancara yang dilakukan kepada Pengelola SALUT dan mahasiswa UT. Hasil penelitian ini menunjukkan bahwa Pembelajaran yang dilakukan pada Salut Kota Batu Universitas Terbuka sangat sulit menjalin interaksi dengan lingkungan. Hal ini disebabkan karena mereka sebagai mahasiswa dihadapkan pada kemajuan teknologi seingga dalam menghubungan karak antar mereka memanfaatkan teknologi tersebut untuk mempersempit jarak yang ada. Beberapa penghambat yang tidak mampu membentuk ruang ilmiah mahasiswa Universitas terbuk adalah keterbatasan interaksi mengingat mekanisme pembelajaran yang dilakukan secara online sehingga tidak memberikan ruang gerak kepada mahasiswa untuk berinteraksi dengan mahasiswa lainya. Selain itu, ketiadaan interaksi bagi mahasiswa tuton terhadap mahasiswa sehingga perkuliahan hanya menekankan pada teoritis dan tidak memberikan pandangan atas interaksi, lingkungan dan rasa sosial yang seharusnya terjalin dalam mekanisme pembelajaran.
Altered amino and fatty acids metabolism in Sudanese prostate cancer patients: insights from metabolic analysis
Authors: Ahmed Dalia , Ebtesam A. Abdel-Shafy  , Elsadig Ahmed Adam Mohammed  , Husam Elden Alnour Bakhet Alnour  , Amar Mohamed Ismail  , Cacciatore Stefano , Luiz Fernando Zerbini  
Published: December 2024

Introduction: Prostate cancer (PCa) management presents a multifaceted clinical challenge, intricately linking oncological considerations with cardiovascular health. Despite the recognized importance of lipid metabolism and hypertension in this interwoven relationship, their involvement in PCa development remains partially understood. This study aimed to explore variations in plasma metabolome among Sudanese PCa patients and their associated comorbidities.
Methods: Plasma samples were collected from 50 patients across four hospitals in Sudan and profiled by nuclear magnetic resonance (NMR) spectroscopy. One-dimensional proton NMR spectra were acquired for each sample using standard nuclear Overhauser effect spectroscopy pulse sequence presat on a 500 MHz Bruker Avance III HD NMR spectrometer. Metabolite concentrations were quantified using R scripts developed in-house. Univariate and multivariate analyses were generated in the R software.
Results: Patients were categorized into four distinct metabotypes based on their metabolic profiles, and statistical analyses were conducted to evaluate the significance of observed differences. Our findings revealed high levels of fatty acids, phospholipids, cholesterol, valine, leucine, and isoleucine associated with non-hypertensive patients. In contrast, hypertensive patients were associated with high GlycA and GlycB levels and altered amino acid metabolism.
Conclusion: These findings underscore the intricate interplay between metabolic dysregulation and hypertension in PCa patients. Further research is warranted to elucidate the precise molecular pathways underlying lipid metabolism in PCa and to explore the therapeutic potential of targeting these pathways. In conclusion, our study contributes to a deeper understanding of the metabolic landscape of PCa in Sudanese patients, emphasizing the importance of personalized approaches in cancer management.
New tools to monitor Pseudomonas aeruginosa infection and biofilms in vivo in C. elegans
Authors: Xue Feng , Ragno Martina , Blackburn Sarah A. , Fasseas Michael , Maitra Sushmita , Liang Mingzhi , Rai Subash , Mastroianni Giulia , Tholozan Frederique , Thompson Rachel , Sellars Laura , Hall Rebecca , Saunter Chris , Weinkove David , Ezcurra Marina 
Published: December 2024

IntroductionAntimicrobial resistance is a growing health problem. Pseudomonas aeruginosa is a pathogen of major concern because of its multidrug resistance and global threat, especially in health-care settings. The pathogenesis and drug resistance of P. aeruginosa depends on its ability to form biofilms, making infections chronic and untreatable as the biofilm protects against antibiotics and host immunity. A major barrier to developing new antimicrobials is the lack of in vivo biofilm models. Standard microbiological testing is usually performed in vitro using planktonic bacteria, without representation of biofilms, reducing translatability. Here we develop tools to study both infection and biofilm formation by P. aeruginosa in vivo to accelerate development of strategies targeting infection and pathogenic biofilms.MethodsBiofilms were quantified in vitro using Crystal Violet staining and fluorescence biofilm assays. For in vivo assays, C. elegans were infected with P. aeruginosa strains. Pathogenicity was quantified by measuring healthspan, survival and GFP fluorescence. Healthspan assays were performed using the WormGazerTM automated imaging technology.ResultsUsing the nematode Caenorhabditis elegans and P. aeruginosa reporters combined with in vivo imaging we show that fluorescent P. aeruginosa reporters that form biofilms in vitro can be used to visualize tissue infection. Using automated tracking of C. elegans movement, we find that that the timing of this infection corresponds with a decline in health endpoints. In a mutant strain of P. aeruginosa lacking RhlR, a transcription factor that controls quorum sensing and biofilm formation, we find reduced capacity of P. aeruginosa to form biofilms, invade host tissues and negatively impact healthspan and survival.DiscussionOur findings suggest that RhlR could be a new antimicrobial target to reduce P. aeruginosa biofilms and virulence in vivo and C. elegans could be used to more effectively screen for new drugs to combat antimicrobial resistance.
A new prediction model for sustained ventricular tachycardia in arrhythmogenic cardiomyopathy
Authors: Zhang Baowei , Xie Xin , Yu Jinbo , Wu Yizhang , Zhou Jian , Li Xiaorong , Yang Bing 
Published: December 2024

BackgroundArrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized by high risks of sustained ventricular tachycardia (sVT) and sudden cardiac death. Identifying patients with high risk of sVT is crucial for the management of ACM.MethodsA total of 147 ACM patients were retrospectively enrolled in the observational study and divided into training and validation groups. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify factors associated with sVT. Subsequently, a nomogram was constructed based on multivariable logistic regression analysis. The performance of the nomogram was evaluated using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis was conducted to assess the clinical utility of the nomogram.ResultsSeven parameters were incorporated into the nomogram: age, male sex, syncope, heart failure, T wave inversion in precordial leads, left ventricular ejection fraction (LVEF), SDNN level. The AUC of the nomogram to predict the probability of sVT was 0.867 (95% CI, 0.797–0.938) in the training group and 0.815 (95% CI, 0.673–0.958) in the validation group. The calibration curve demonstrated a good consistency between the actual clinical results and the predicted outcomes. Decision curve analysis indicated that the nomogram had higher overall net benefits in predicting sVT.ConclusionWe have developed and internally validated a new prediction model for sVT in ACM. This model could serve as a valuable tool to accurately identify ACM patients with high risk of sVT.
New isotopic evidence for micro and mesothermal valleys camelids from Northwest Argentina
Authors: Killian Galván Violeta Anahí , Belotti López de Medina Carlos Raúl , Bugliani María Fabiana , Spano Romina Clara 
Published: December 2024

IntroductionDomestic and wild camelids were the most significant meat resource for pre-Hispanic agropastoral societies in the Argentine Northwest's micro valleys (between 2,500 and 3,400 masl) and mesothermal valleys (2,500 and 1,500 masl), with varying relative importance in comparison to cultivated and collected plants. Examining pastoral movement techniques, as well as the areas available for wild resource gathering, allows us to acquire a better understanding of the nature and scale of social structure among these human communities. Stable isotope analyses of carbon (13C/12C; δ13C) and nitrogen (15N/14N; δ15N) provide efficient tools for understanding these features.MethodsThe article shows the bone collagen measurements of a sample of camelid bones from archaeofaunas recovered from Soria 2 sites (n = 7) and structure 93 of Loma l'Ántigo (n = 5), all in Catamarca province. The first is a residential unit in the Yocavil valley (2,400 masl), and its chronology corresponds to the beginning of the region's Formative Period. The second is in the Cajón Valley (2,700 masl) and dates to the Regional Developments Period. Bone specimens were previously categorized to genus or species rank employing morphological and osteometric criteria.ResultsOur results suggest that C4 plants have been important in animal diets since the Formative period. At the same time, access to pastures or wildlife at high altitudinal levels persisted during the Regional Developments, with the possibility of a fodder intensification strategy also based on C3 plants.DiscussionSuch kind of data allows us to assess whether a livestock intensification plan based on corn provision coincided with social, political, and economic changes in the early second millennium AD.
Tree-ring δ18O and δ2H stable isotopes reflect the global meteoric water line
Authors: Arosio Tito , Büntgen Ulf , Nicolussi Kurt , Moseley Gina E. , Saurer Matthias , Pichler Thomas , Smith M. Paul , Gutierrez Emilia , Andreu-Hayles Laia , Hajdas Irka , Bebchuk Tatiana , Leuenberger Markus 
Published: December 2024

IntroductionThe Global Meteoric Water Line (GMWL) describes the linear relationship between stable hydrogen (δ2H) and oxygen (δ18O) isotopes in precipitation over large spatial scales and therefore represents a unique reference for water isotopic values. Although trees have the potential to capture the isotopic composition of precipitation, it remains unclear if the GMWL can be reconstructed from tree-ring stable isotopes, since δ18O and δ2H undergo in vivo physiological fractionation.MethodsWe analyze the tree rings δ18O and δ2H values from six regions along a latitudinal gradient from Spain to Greenland. ResultsThe data show that the covariance between δ18O and δ2H closely follows the GMWL, which reflects the isotopic signature of large-scale precipitation patterns. We show that changes in regional tree-ring δ18O and δ2H values along wide latitudinal ranges are influenced by the isotopic composition of precipitation with temperature and latitude being the most significant drivers of spatial variation across the studied regions. In contrast, local tree-ring δ18O and δ2H values are mainly controlled by plant physiological fractionation processes that mask the isotopic signature of precipitation.ConclusionWe conclude that covariance in tree-ring δ18O and δ2H reflects the GMWL at larger spatial scales, but not when evaluating them at individual sites.
The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis
Authors: Gao Jie , Zhang Xiuzhen , Ding Jing , Zhang Houli , Zhang Xu , Jiang Juan , Chen Wenwen 
Published: December 2024

ObjectiveTo evaluate the characteristics of the circulating microRNA expression profiles in patients with osteoporosis.MethodsA systematic literature search was performed using the Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and WANFANG databases from inception until 1 March 2024. The search strategy employed keywords, encompassing “osteoporosis”, “bone loss”, or “osteopenia” and “miRNA” or “microRNA”. The Newcastle-Ottawa Scale (NOS) quality assessment scale was used to evaluate the methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the weighted mean difference (WMD) and 95% confidence interval (95% CI).ResultsA total of 27 studies were included and analyzed in the meta-analysis, with 2,263 participants. The results showed that miR-21-5p (WMD 0.88, 95% CI: 0.22 to 1.55), miR-125b-5p (WMD 6.63, 95% CI: 0.19 to 13.08), miR-483-5p(WMD 6.43, 95% CI: 3.26 to 9.61), miR-133a (WMD 1.43, 95% CI: 1.39 to 1.47), miR-422a (WMD 1, 95% CI: 0.28 to 1.72), and miR-214-3p (WMD 2.03, 95% CI: 0.14 to 3.92) were significantly upregulated, and miR-497-5p (WMD -0.57, 95% CI: -0.98 to -0.17) was significantly downregulated.ConclusionmiR-21-5p, miR-125b-5p, miR-483-5p, miR-133a, miR-497-5p, miR-422a, and miR-214-3p might serve as potential diagnostic biomarkers for osteoporosis. In the future, integrating these miRNAs to build a diagnostic model might be a promising diagnosis strategy for osteoporosis.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023481209.
Impaired interhemispheric synchrony in patients with iridocyclitis and classification using machine learning: an fMRI study
Authors: Tong Yan , Wen Zhi , Huang Xin 
Published: December 2024

BackgroundThis study examined the interhemispheric integration function pattern in patients with iridocyclitis utilizing the voxel-mirrored homotopic connectivity (VMHC) technique. Additionally, we investigated the ability of VMHC results to distinguish patients with iridocyclitis from healthy controls (HCs), which may contribute to the development of objective biomarkers for early diagnosis and intervention in clinical set.MethodsTwenty-six patients with iridocyclitis and twenty-six matched HCs, in terms of sex, age, and education level, underwent resting-state functional magnetic resonance imaging (fMRI) examinations. The study employed the voxel-mirrored homotopic connectivity (VMHC) technique to evaluate interhemispheric integration functional connectivity indices at a voxel-wise level. The diagnostic efficacy of VMHC was evaluated using a support vector machine (SVM) classifier, with classifier performance assessed through permutation test analysis. Furthermore, correlation analyses was conducted to investigate the associations between mean VMHC values in various brain regions and clinical features.ResultsPatients with iridocyclitis exhibited significantly reduced VMHC signal values in the bilateral inferior temporal gyrus, calcarine, middle temporal gyrus, and precuneus compared to HCs (voxel-level P &lt; 0.01, Gaussian Random Field correction; cluster-level P &lt; 0.05). Furthermore, the extracted resting-state zVMHC features effectively classified patients with iridocyclitis and HCs, achieving an area under the receiver operating characteristic curve (AUC) of 0.74 and an overall accuracy of 0.673 (P &lt; 0.001, non-parametric permutation test).ConclusionOur findings reveal disrupted interhemispheric functional organization in patients with iridocyclitis, offering insight into the pathophysiological mechanisms associated with vision loss and cognitive dysfunction in this patient population. This study also highlights the potential of machine learning in ophthalmology and the importance of establishing objective biomarkers to address diagnostic heterogeneity.