bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age at first childbirth and breast cancer survival: a prospective cohort study
Authors: Aurin Johanna , Thorlacius Henrik , Butt Salma Tunå 
Published: January 2020

Abstract
Objective
Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis.

Results
We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, > 20 to  ≤ 25, > 25 to  ≤ 30 and > 30. Nulliparous women form a separate group. Survival analyses were then performed using Cox proportional hazard survival analysis. Women in all age groups had a lower risk of breast cancer specific death as compared to the reference group ≤ 20, however non-significantly. Nulliparous women had a higher risk of breast cancer specific death as compared to the same reference group, however these results were not statistically significant. We could not see any negative effect of late first childbirth on breast cancer specific survival.
Endometrial stromal cells exhibit a distinct phenotypic and immunomodulatory profile
Authors: Queckbörner Suzanna , Syk Lundberg Elisabeth , Gemzell-Danielsson Kristina , Davies Lindsay C. 
Published: January 2020

Abstract
Background
In Asherman’s syndrome (AS), intrauterine scarring and fibrotic adhesions lead to menstrual disorders, pregnancy loss, or infertility. A few clinical trials have piloted cell therapy to overcome AS. Understanding the role of the stromal compartment in endometrial regeneration remains poorly understood. We hypothesize that endometrial stromal cells (eSCs) represent a relevant cell population to establish novel cell-based therapeutics for endometrial disorders. The aim of this study was to characterize eSCs and evaluate their immune-cell interactions.

Methods
eSCs were isolated from healthy donors, during the proliferative stage of the menstrual cycle. Cells were characterized for expression of mesenchymal stromal cell (MSC) markers and assessed for their tumorigenic potential. eSCs were co-cultured with interferon γ and tumor necrosis factor α, and cell surface expression of their respective receptors and human leukocyte antigen (HLA) I and II determined by flow cytometry. Secreted levels of key immunomodulatory factors were established. eSCs were cultured with activated peripheral blood mononuclear cells, and T cell differentiation and proliferation determined.

Results
eSCs demonstrated an MSC surface phenotype and exhibited multipotency. Expanded eSCs retained chromosomal stability and demonstrated no tumorigenicity. Upon stimulation, eSCs licensed to an anti-inflammatory phenotype with upregulated secretion of immunomodulatory factors. Stimulated eSCs did not express HLA class II. eSCs suppressed the proliferation and activation of CD4+ T cells, with the eSC secretome further downregulating central memory T cells and upregulating effector memory (EM) cells.

Conclusions
Differential responsiveness to inflammation by eSCs, compared to other MSC sources, demonstrates the need to understand the specific functional effects of individual stromal cell sources. A lack of HLA class II and triggering of EM T cell differentiation strongly links to innate in vivo roles of eSCs in tissue repair and immune tolerance during pregnancy. We conclude that eSCs may be an ideal cell therapy candidate for endometrial disorders.
[18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer
Authors: Jouberton Elodie , Schmitt Sébastien , Chautard Emmanuel , Maisonial-Besset Aurélie , Roy Marie , Radosevic-Robin Nina , Chezal Jean-Michel , Miot-Noirault Elisabeth , Bouvet Yann , Cachin Florent 
Published: January 2020

Abstract
Purpose
Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option for this is molecular imaging of apoptosis induced by chemotherapy. Therefore, we investigated the capacity of [18F]ML-10 PET imaging, an apoptosis radiotracer, to detect tumor cell apoptosis and early predict the therapeutic response of human TNBC.

Results
Initially, the induction of apoptosis by different therapies was quantified. We confirmed, in vitro, that paclitaxel or epirubicin, the fundamental cytotoxic drugs for breast cancer, induce apoptosis in TNBC cell lines. Exposure of TNBC models MDA-MB-231 and MDA-MB-468 to these drugs induced a significant increase (p < 0.01) of the apoptotic hallmarks: DNA fragmentation, membrane phospholipid scrambling, and PARP activation. Secondarily, apoptotic fraction was compared to the intracellular accumulation of the radiotracer. [18F]ML-10 accumulated in the apoptotic cells after 72 h of treatment by paclitaxel in vitro; this accumulation positively correlated with the apoptotic fraction. In vivo, [18F]ML-10 was rapidly cleared from the nontarget organs and mainly eliminated by the kidneys. Comparison of the in vivo [18F]FDG, [18F]FMISO, and [18F]ML-10 uptakes revealed that the tumor accumulation of [18F]ML-10 was directly related to the tumor hypoxia level. Finally, after the in vivo treatment of TNBC murine xenografts by paclitaxel, apoptosis was well induced, as demonstrated by the cleaved caspase-3 levels; however, no significant increase of [18F]ML-10 accumulation in the tumors was observed, either on day 3 or day 6 after the end of the treatment.

Conclusions
These results highlighted that PET imaging using [18F]ML-10 allows the visualization of apoptotic cells in TNBC models. Nevertheless, the increase of the chemotherapy-induced apoptotic response when using paclitaxel could not be assessed using this radiotracer in our mouse model.
A new method to solve the problem of facing less learning samples in signal modulation recognition
Authors: Fu Sibao , Liu Xiaokai 
Published: January 2020

AbstractIn machine learning method, the number of training samples is an exceedingly important factor determining the learning system’s robustness. In our previous researches (Liu et al., J. Syst. Eng. Electron. 27.2:333–342, 2016; Liu et al., IET Commun. 11.7:1000–1007, 2017), the extreme learning machines (ELMs) have proven to be an effective and time-saving learning method for pattern classification and the signal modulation recognition. ELMs are utilized to supervised learning issues principally on signal modulation recognition. In this thesis, ELMs are extended for semi-supervised tasks that are based on the manifold regularization, therefore greatly enlarging ELMs’ applicability. This article evolves countermeasures to the less training samples which mitigate the modulation recognition efficacy and demonstrates the robustness of semi-supervised learning for signal classification in AWGN and Rayleigh-fading channels.
Reducing meat consumption by appealing to animal welfare: protocol for a meta-analysis and theoretical review
Authors: Mathur Maya B. , Robinson Thomas N. , Reichling David B. , Gardner Christopher D. , Nadler Janice , Bain Paul A. , Peacock Jacob 
Published: January 2020

AbstractBackgroundReducing meat consumption may improve human health, curb environmental damage and greenhouse gas emissions, and limit the large-scale suffering of animals raised in factory farms. Previous work has begun to develop interventions to reduce individual meat consumption, often by appealing directly to individual health motivations. However, research on nutritional behavior change suggests that interventions additionally linking behavior to ethical values, identity formation, and existing social movements may be particularly effective and longer-lasting. Regarding meat consumption, preliminary evidence and psychological theory suggest that appeals related to animal welfare may have considerable potential to effectively leverage these elements of human psychology. We aim to conduct a systematic review and quantitative meta-analysis evaluating the effectiveness of animal welfare-related appeals on actual or intended meat consumption or purchasing. Our investigation will critically synthesize the current state of knowledge regarding psychological mechanisms of intervening on individual meat consumption and empirically identify the psychological characteristics underlying the most effective animal welfare-based interventions.MethodsWe will systematically search eight academic databases and extensively search unpublished grey literature. We will include studies that assess interventions intended to reduce meat consumption or purchase through the mention or portrayal of animal welfare, that measure outcomes related to meat consumption or purchase, and that have a control condition. Eligible studies may recruit from any human population, be written in any language, and be published or released any time. We will meta-analyze the studies, reporting the pooled point estimate and additional metrics that describe the distribution of potentially heterogeneous effects. We will assess studies’ risk of bias and conduct sensitivity analyses for publication bias. We describe possible follow-up analyses to investigate hypothesized moderators of intervention effectiveness.DiscussionThe findings of the proposed systematic review and meta-analysis, including any identified methodological limitations of the existing literature, could inform the design of successful evidence-based interventions with broad potential to improve human, animal, and environmental well-being.Systematic review registrationThe protocol was preregistered via the Open Science Framework (https://osf.io/d3y56/registrations).
Indoor acoustic localization: a survey
Authors: Liu Manni , Cheng Linsong , Qian Kun , Wang Jiliang , Wang Jin , Liu Yunhao 
Published: January 2020

Abstract
Applications of localization range from body tracking, gesture capturing, indoor plan construction to mobile health sensing. Technologies such as inertial sensors, radio frequency signals and cameras have been deeply excavated to locate targets. Among all the technologies, the acoustic signal gains enormous favor considering its comparatively high accuracy with common infrastructure and low time latency. Range-based localization falls into two categories: absolute range and relative range. Different mechanisms, such as Time of Flight, Doppler effect and phase shift, are widely studied to achieve the two genres of localization. The subcategories show distinguishing features but also face diverse challenges. In this survey, we present a comprehensive overview on various indoor localization systems derived from the various mechanisms. We also discuss the remaining issues and the future work.
Dietary diversity among school age children in Merawi town, Amhara region, Ethiopia, 2018: a community based cross-sectional study
Authors: Tewabe Tilahun , Belachew Amare , Miskir Yihun , Mekuria Getnet 
Published: January 2020

Abstract
Background
Malnutrition with its constituents of protein energy malnutrition and micro-nutrient deficiencies continues to be a major health burden in low and middle-income countries. To end all forms of malnutrition, we need to address poverty, which is associated with the insecure supply of food and diversified nutrition. The objective of this study was to determine the level of dietary diversity and household food security among urban school-age children in Merawi town, Ethiopia.

Methods
A community based cross-sectional study was conducted in Merawi town among 422 households having school age children from April 1 to June 15, 2018. The association between dietary diversity and determinants was assessed using binary logistic regression analysis. Socio-demographic, maternal and child related variables; food security and diversity determinants were studied.

Results
The overall level of good dietary diversity was 91.7%, i.e.; 8.3% had a low, 59.1% had a good, 32.6% had better dietary diversity, respectively. Most households (95.2%) were secured with food access. The factors associated with good dietary diversity were the age of the child [AOR = 0.31 (0.14, 0.70)], and access to information [AOR = 3.18 (1.07,9.47)].

Conclusion
The prevalence of good dietary diversity was relatively high. Among different socio-cultural and economic factors studied, age of the child and access to information were the factors associated with dietary diversity. Increasing maternal and child awareness towards good dietary diversity practices through the mass media (radio and Television) and working with mothers with early school-age children to improve dietary diversity are recommended.
The term structure, leading indicators, and recessions: evidence from Switzerland, 1974–2017
Authors: Stuart Rebecca 
Published: January 2020

AbstractThis paper studies the predictive power for recessions of the slope of the Swiss term structure using monthly data for 1974–2017. Dynamic probit models indicate that the term structure contains information useful for predicting recessions for horizons up to 19 months. Whether the economy is currently in recession or not is also useful for forecasting recessions. These relationships prove stable over the sample. Robustness tests indicate that the KOF business course indicator and some monetary aggregates contain different information from the term structure which can improve the in- and out-of-sample fit of the model.
Recurrent mandibular ameloblastoma in soft tissue and rib graft 17 years after initial presentation
Authors: Hamdy Omar , Raafat Sara , Saleh Gehad A. , Awny Shadi , Shebl Abdelhadi M. , Hegazy Mohammed A. 
Published: January 2020

Abstract
Background
Ameloblastoma is the commonest odontogenic tumour of epithelial origin with a high incidence for developing local recurrence. We present a patient who developed local recurrence in both soft tissue and bone graft 17 years after the initial presentation.

Case presentation
A 75-year-old female with a previous history of right hemimandibulectomy and rib reconstruction for ameloblastoma in 1999 presented to our centre with a large cystic mouth floor swelling, biopsy from which revealed recurrent ameloblastoma. The patient underwent excision of the recurrent mass en bloc with the cystic swelling through oral and cervical approaches. The patient was discharged after 5 days with an uneventful postoperative course and with a free 2-year follow-up from further recurrence.

Conclusion
Ameloblastoma is a locally aggressive tumour for which wide local excision with adequate margins is the best management approach. Recurrence of ameloblastoma even after adequate resection is not uncommon, and its management is considered a surgical challenge. A very long time may pass between the initial presentation and the development of recurrence.
Endoscopic versus open harvesting of radial artery for CABG
Authors: Fouly Mohamed Abdel Hafez 
Published: January 2020

Abstract
Background
Endoscopic harvest of the radial artery avoids long forearm incisions and has better cosmesis compared to the open technique. The objective of this study was to compare the short-term results and wound-related complications of endoscopic radial artery harvest versus open technique.

Results
From 2013 to 2017, 800 patients had coronary artery bypass grafting; 88 patients of them had radial artery harvesting (11%). Two groups were included in the study according to the surgeon preference, endoscopic radial harvest (group 1, n = 30; 3.75% of total CABG patients) and open harvest (group 2, n = 58; 7.25% of total CABG patients). Group 1 had more males (25 (83.33%) vs. 35 (60.34%); p = 0.028). There was no difference in the preoperative comorbidities between both groups. The duration of the harvest was significantly longer in group 1 (median 40 min ranges from 38 to 42 min vs. 49 min ranges from 47 to 52 min in groups 1 and 2, respectively; p < 0.001). The operative time was longer in group 1 (median 302.5 min ranges from 295 to 310 min vs. 277 min ranges from 273 to 280 min in groups 1 and 2, respectively; p < 0.001). The hospital stay in the endoscopic radial artery harvest group was significantly shorter than that of open technique (median 7 days ranges from 6 to 7 days vs. 7.5 days ranges from 7 to 9 days; p < 0.001). There was no significant difference in the postoperative complications between both groups. One case (3.3%) was transformed from the endoscopic to open technique due to uncontrolled bleeding. Endoscopic technique was associated with more patients presenting with hand numbness (6 cases; 20% versus 3 cases 5.2%) and radial nerve injury (2 cases; 6.6% versus none), while open technique showed more cases of local hematoma (8 cases; 13.8% versus 1 case; 3.3%) and wound infection (6 cases; 10.34% versus none); p > 0.05.

Conclusion
Endoscopic radial artery harvest is associated with shorter harvest time and shorter hospital stay. Endoscopic radial artery harvest is a safe technique with good short-term outcomes. Longer follow-up is recommended.
Association between childhood trauma and multimodal early-onset hallucinations
Authors: Medjkane François , Notredame Charles-Edouard , Sharkey Lucie , D'Hondt Fabien , Vaiva Guillaume , Jardri Renaud 
Published: January 2020

SummaryPrevious reports suggest that adverse events during childhood could be related to an array of psychiatric problems. Here, we question the relationship between childhood traumatic experiences and the sensory complexity of hallucinations in a cohort of 75 children and adolescents. We evidence a positive link between the number of sensory modalities involved in hallucinations and history of childhood trauma, even after controlling for the co-occurrence of suicidal ideation or the number of ICD-10 diagnoses. These findings support initiatives in which a routine exploration of traumatic events in childhood is performed when multimodal hallucinations are present.
A bioactive compound isolated from Duku (Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line
Authors: Fadhilah Khusnul , Wahyuono Subagus , Astuti Puji 
Published: January 2020

Background: Breast cancer is a major health problem for women globally. Many attempts have been promoted to cure cancer by finding new anticancer medicines from natural resources. Despite the richness of biodiversity discovered, there are some natural resources that remain unexplored. Fruit peels of Duku (Lansium domesticum Corr.) are rich with compounds that may have the potential to be developed as anticancer drugs. This study aimed to isolate cytotoxic compounds from the fruit peels of L. domesticum and assess their cytotoxic nature against T47D cells. Methods: Powdered peels were macerated with ethyl acetate and the filtrate was evaporated to give EtOAc extract A. Dried extract A was triturated with n-hexane to give n-hexane soluble fraction B and insoluble fraction C. The cytotoxic nature of these three samples were assessed using MTT assay using T47D cells and doxorubicin as a control. Results: Fraction C that showed the smallest IC50 (25.56 ± 0.64μg/mL) value compared to extract A and fraction B. Fraction C was further fractionated by vacuum liquid chromatography to give 6 subfractions. Subfraction 2 showed a single compound based on thin layer chromatography, and this compound was identified as Lamesticumin A on the basis of its spectroscopic data. Lamesticumin A demonstrated cytotoxic activity against T47D cell lines with an IC50 value of 15.68 ± 0.30µg/mL. Conclusions: Further research is needed to investigate the potential of the natural compound Lamesticumin A derived from L. domesticum fruit peel as an anticancer therapy.
Independent predictors of comprehensive knowledge of HIV in general population: findings from the Myanmar Demographic and Health Survey (2015-16)
Authors: Show Kyaw Lwin , Shewade Hemant Deepak , Kyaw Khine Wut Yee , Wai Khin Thet , Hone San , Oo Htun Nyunt 
Published: January 2020

Background: Myanmar has the third highest number of people living with HIV in Southeast Asia behind Indonesia and Thailand. The independent predictors of comprehensive HIV knowledge among general population are not known. Methods: In this nationally representative study, we adopted a cross-sectional design using secondary data from the Myanmar Demographic and Health Survey (2015-16). We included all women and men aged 15-49 years who participated in the survey. We have provided weighted estimates as the analyses were weighted for the multi-stage sampling design. We used modified Poisson regression with robust variance estimates model to identify independent predictors of comprehensive knowledge. Results: Of 17,622 analyzed, 3,599 (20.4%, 95% CI: 19.7, 21.1) had comprehensive knowledge of HIV. Late adolescents, those with less than a high school education, those involved in agriculture and the poorest two quintiles were less likely to have comprehensive knowledge of HIV. Conclusion: In Myanmar, comprehensive knowledge of HIV among the general population needs to be improved and we identified certain independent predictors that could be specifically targeted by the national programme.
Decision trees in environmental justice research — a case study on the floods of 2001 and 2010 in Hungary
Authors: Nagy Gyula , Vida György , Boros Lajos , Ćirić Danijela 
Published: January 2020

Abstract
Environmental justice is a normative framework for the analysis of environmental impacts on the wellbeing of individuals and social groups. According to the framework, the deprived social groups and ethnic minorities are often more exposed to environmental risks and hazards due to their disadvantaged situation, and due to the lack of representation and political power. To manage the impacts of injustices and to include the citizen in the decision-making processes, proper information is needed on local attitudes and decision-making processes. Therefore, this study sought to (i) identify the main factors shaping the attitudes towards environmental injustices and (ii) to analyse the attitudes and perception of the various social groups and (iii) to identify the main factors which are shaping the attitudes and actions of those who were affected by the floods of 2001 and 2010 through the use of decision tree method. The data for the predictive model was acquired from a questionnaire survey conducted in two disadvantaged and flood-hit Hungarian regions. Based on the survey data, a principal component analysis (PCA) was conducted, which resulted in three principal components; fear, social change, and change in the built environment. The study focused only on the elements of the “fear principal component”, due to the decision tree tool homogenous groups identified in relation to this component. Our analysis showed that ethnicity has a determinative role in the emergence and the level of fear from floods; the Roma respondents expressed a significantly higher level of fear than others.