bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain quality management and organizational performance
Authors: Hussain Matloub , Khan Mehmood , Ajmal Mian , Ahmad Khan Bilal 
Published: December 2019

PurposeSupply chain quality management (SCQM) has gained less attention in the Arab world, and there is a clear dearth in existing research on this topic, particularly in service organizations. Therefore, the purpose of this paper is to propose a conceptual framework for investigating the impact of SCQM and associated indicators on organizational performance (OP).Design/methodology/approachEmpirical data have been collected through a survey distributed to a sample of major telecom companies in United Arab Emirates (UAE). To test the conceptual framework, structural equation modeling (SEM) has been used to analyze the data collected from 248 respondents of telecom companies.FindingsThe empirical data showed that SCQM practices are significantly correlated with innovation and operations performance. Statistical analysis through SEM also revealed that customer satisfaction has highest direct impact on OP.Research limitations/implicationsExternal factors (government regulations, policies and culture) also affect the SCQM practices. Hence, future work should incorporate these parameters as well.Practical implicationsThis is a contribution to the continuing research into SCQM, giving supply chain managers and designers a practical way for measuring and implementing SCQM practices across service supply chains.Originality/valueThe contribution of this research, through successive stages of data collection, measurement analysis and refinement, is a set of reliable and valid framework that can be subsequently used in conceptualization and measuring quality of service supply chains.
Ch’ulel Mendoza, un spa diferente: estudio de caso sobre el desarrollo de un nuevo producto en la industria del bienestar
Authors: George Babu , Marano Gina , Henthorne Tony 
Published: December 2019

Learning outcomes
Desarrollar un plan de negocios integral para una empresa nueva. Entender el ambiente de negocios. Prepare un análisis DAFO. Desarrollar planes funcionales (de mercadeo, finanzas, recursos humanos, operaciones, etc.). Entender las oportunidades y desafíos del proceso de desarrollo de un nuevo producto.

Case overview/synopsis
Este estudio de caso traza el desarrollo de un plan de negocios para Ch’ulel Mendoza, un complejo de villas ubicado en la Cordillera de los Andes en Argentina, en donde los huéspedes disfrutan de lujosos tratamientos de spa basados en el uso de vino. El plan de negocios debe ser integral, pues se convertirá en la base de un proyecto completamente establecido para posibles inversionistas. Ch’ulel Mendoza está rodeado por los exuberantes viñedos de algunas de las fincas vinícolas más famosas de Argentina. El spa, las instalaciones y los servicios rinden homenaje al patrimonio vitivinícola de la región, promoviendo el vino entre sus huéspedes como algo placentero para consumir y propicio para llevar una vida saludable. El diseño arquitectónico es un guiño directo a la vid: el spa cubierto de tierra es donde los huéspedes absorben los nutrientes curativos de los tratamientos de vinoterapia y de agua, de la misma manera en la que las raíces se nutren de los elementos y el agua provenientes de la tierra; el área del resort aprovecha el espacio al aire libre con terrazas, patios abiertos y piscinas en las que los huéspedes pueden tomar el sol y disfrutar de otros elementos naturales, tal y como lo hacen las plantas de uva. Cuando entre en operación, Ch’ulel Mendoza simbolizará bienestar, recreación y el encanto de la cultura latinoamericana.

Complexity academic level
Nivel de pregrado y posgrado

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 12: Tourism and Hospitality.
La industria chilena del vino: nuevas estrategias internacionales Para 2020
Authors: Felzensztein Christian 
Published: December 2019

Learning outcomes
Los estudiantes deben poder realizar un claro análisis competitivo con la información provista en el caso. Los estudiantes también deben desarrollar mapas de posicionamiento, análisis SWOT (debilidades, amenazas, fortalezas y oportunidades), visión, misión, análisis comparativo, segmentación, estrategias de focalización y posicionamiento para mercados internacionales. Los temas de efecto país de origen e imagen de país son relevantes también para el análisis y posicionamiento de los vinos chilenos en mercados internacionales.

Case overview/synopsis
La industria Chilena del vino ha atravesado numerosas y profundas transformaciones en los últimos treinta años. Estas transformaciones han permitido que una nueva generación de talentosos viticultores y vinicultores capitalicen el paraíso vitivinícola de Chile y produzcan vinos de clase mundial. Chile exporta el 70% de su producción vinícola, lo que la convierte en la industria vinícola más globalizada del mundo. A pesar de este éxito innegable, los vinos chilenos enfrentan altos niveles de competencia en los diferentes mercados globales, y sus precios promedio son sustancialmente menores que los de sus competidores. Por consiguiente, los niveles actuales de rentabilidad de la industria son bajos, y existe una urgente necesidad de elevar el posicionamiento premium y los precios promedio para lograr un retorno sostenible en el largo plazo. La industria chilena del vino está preparando un nuevo plan estratégico y una estrategia internacional de mercadeo para 2020, con lineamientos para un vigoroso camino de desarrollo internacional que defina la visión, misión, posicionamiento, objetivos estratégicos, oportunidades y planes de acción de la industria con una nueva perspectiva estratégica de mercadeo. El objetivo de este caso es desarrollar este nuevo plan estratégico y estrategia internacional de mercadeo para la industria vinícola de Chile.

Complexity academic level
MBA y maestría (negocios internacionales, mercadeo, mercadeo internacional).

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Exploration/exploitation innovation and firm performance: the mediation of entrepreneurial orientation and moderation of competitive intensity
Authors: Hou Bojun , Hong Jin , Zhu Ruonan 
Published: December 2019

PurposeAlthough many scholars have found that exploration and exploitation innovation have significantly positive effects on firm performance, it remains to be resolved whether the relationship between the two is still established at different stages of enterprise development and in different competitive contexts. This paper aims to clarify the effect of exploration/exploitation innovation on firm performance in start-ups, and in particular, the mediation role of entrepreneurial orientation (EO) and the moderation role of competitive intensity are tested to explore their disturbing effects on above relationship.Design/methodology/approachThe authors construct a theoretical framework to analyze and verify the relationship between innovation, EO and firm performance. The hypotheses of this paper are put forward by theoretical inference. In addition to test the hypotheses, 143 questionnaires are collected from technology-oriented start-ups in Hefei National University Science Park.FindingsThe empirical results show that consistent with previous findings, exploration innovation and exploitation innovation both have positive impact on firm performance; meanwhile, the EO partially mediates the relationship between both innovations and firm performance. What cannot be ignored is that the competition intensity plays a moderation role between EO and firm performance.Originality/valueThe findings reveal that the impact of innovation activities on corporate performance has been disrupted by EO and competition intensity in start-ups. The work of this paper deepens the understanding of the relationship between innovation, EO, external environment and firm performance, which is of guiding significance to the entrepreneurship management of emerging economies.
The relationship between organizational learning capability and business performance
Authors: Pham Lien Thi , Hoang Ha Viet 
Published: December 2019

Purpose
The purpose of this paper is to explore the relationship between organizational learning capability and business performance of Vietnamese firms.

Design/methodology/approach
Based on the literature review, the authors proposed five hypotheses covering the relationships between different dimensions of organizational learning capability and business performance. Data collected from a survey of 160 Master of Business Administration students working in different firms in Vietnam were analyzed to test the proposed hypotheses.

Findings
The results confirmed that organizational learning capability has positive effect on business performance. Moreover, two out of four dimensions of organizational learning capability are having positive relationship with business performance (management commitment to learning and “knowledge transfer and integration”).

Practical implications
The paper gives some suggestions for firms to improve their business performance through enhancing organizational learning capability.

Originality/value
This study provides important insights into the recognized yet under-researched relationship between organizational learning capability and business performance and confirms that organizational learning capability has a positive impact on business performance in Vietnam context.
Time‐resolved dual RNA‐seq of tissue uncovers Pseudomonas plecoglossicida key virulence genes in host‐pathogen interaction with Epinephelus coioides
Authors: Luo Gang , Sun Yujia , Huang Lixing , Su Yongquan , Zhao Lingmin , Qin Yingxue , Xu Xiaojin , Yan Qingpi 
Published: December 2019

SummaryBacterial pathogen‐host interactions are highly dynamic, regulated processes that have been primarily investigated using in vitro assays. The dynamics of bacterial pathogen‐host interplay in vivo are poorly understood. Using time‐resolved dual RNA‐seq in a Pseudomonas plecoglossicida‐Epinephelus coioides infection model, we observed that bacterial genes encoding classical virulence factors and host genes involved in immune regulation were dynamically expressed during infection. Using network inferencing, we were able to predict interspecies regulatory networks linking bacterial virulence genes to host immune genes. Together with gene co‐expression network analysis of the pathogen, secY was predicted to be a key virulence gene for P. plecoglossicida pathogenicity in the host, fliN was predicted to be a less important virulence gene. The results of bioinformatics prediction were confirmed by animal infection experiments. Our work provides the first paradigm to study dynamic alterations of bacterial pathogen and host interactions based on the elucidation of time‐resolved interactive transcriptomes in vivo, and may be developed into a novel and universal method for revealing the true complexity of the bacterial infection process.
The Association of State Opioid Misuse Prevention Policies With Patient‐ and Provider‐Related Outcomes: A Scoping Review
Authors: MAURI AMANDA I. , TOWNSEND TARLISE N. , HAFFAJEE REBECCA L. 
Published: December 2019

Policy Points
This scoping review reveals a growing literature on the effects of certain state opioid misuse prevention policies, but persistent gaps in evidence on other prevalent state policies remain.
Policymakers interested in reducing the volume and dosage of opioids prescribed and dispensed can consider adopting robust prescription drug monitoring programs with mandatory access provisions and drug supply management policies, such as prior authorization policies for high‐risk prescription opioids.
Further research should concentrate on potential unintended consequences of opioid misuse prevention policies, differential policy effects across populations, interventions that have not received sufficient evaluation (eg, Good Samaritan laws, naloxone access laws), and patient‐related outcomes.
ContextIn the midst of an opioid crisis in the United States, an influx of state opioid misuse prevention policies has provided new opportunities to generate evidence of policy effectiveness that can inform policy decisions. We conducted a scoping review to synthesize the available evidence on the effectiveness of US state interventions to improve patient and provider outcomes related to opioid misuse and addiction.MethodsWe searched six online databases to identify evaluations of state opioid policies. Eligible studies examined legislative and administrative policy interventions that evaluated (a) prescribing and dispensing, (b) patient behavior, or (c) patient health.FindingsSeventy‐one articles met our inclusion criteria, including 41 studies published between 2016 and 2018. These articles evaluated nine types of state policies targeting opioid misuse. While prescription drug monitoring programs (PDMPs) have received considerable attention in the literature, far fewer studies addressed other types of state policy. Overall, evidence quality is very low for the majority of policies due to a small number of evaluations. Of interventions that have been the subject of considerable research, promising means of reducing the volume and dosages of opioids prescribed and dispensed include drug supply management policies and robust PDMPs. Due to low study number and quality, evidence is insufficient to draw conclusions regarding interventions targeting patient behavior and health outcomes, including naloxone access laws and Good Samaritan laws.ConclusionsRecent research has improved the evidence base on several state interventions targeting opioid misuse. Specifically, moderate evidence suggests that drug supply management policies and robust PDMPs reduce opioid prescribing. Despite the increase in rigorous evaluations, evidence remains limited for the majority of policies, particularly those targeting patient health–related outcomes.
Recent advances in heterocyclic aromatic amines: An update on food safety and hazardous control from food processing to dietary intake
Authors: Chen Xiaoqian , Jia Wei , Zhu Li , Mao Lei , Zhang Yu 
Published: December 2019

AbstractHeterocyclic aromatic amines (HAAs) as probable carcinogenic substances are mainly generated in meat products during thermal processing. Numerous studies have contributed to the analysis, formation, and mitigation of HAAs during food processing. However, few articles have comprehensively reviewed food safety aspects from both food processing and dietary intake regarding the formation, mitigation, metabolism, biomarkers for exposure, hazard control, and risk assessment of HAAs, and related food safety researches. Several factors may influence the generation of HAAs, including processing temperature, processing time, and chemical composition of the meat. Nonetheless, these mutagenic compounds are attenuated to different levels by the addition of natural or synthetic flavorings and antioxidant‐rich marinades, as well as pretreatments using technique such as microwave heating. After dietary intake, different types of HAAs are metabolized in humans by several enzymes, including cytochrome P450s, peroxidases, N‐acetyltransferases, sulfotransferases, uridine diphosphate‐glucuronosyltransferases, and glutathione S‐transferases. Their primary metabolites are further conjugated with DNA or ultimately excreted in urine and feces. The 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in hair as well as DNA, hemoglobin, and serum albumin adducts has been considered as biomarkers for exposure assessment. Dietary intake information obtained from questionnaires and the results of epidemiological investigations have shown a positive relationship between the intakes of red meat and processed meat and high risk of cancer incidence. As several cancers have been reported to be associated with HAAs, HAAs should be both effectively reduced during food processing and controlled from dietary intake to facilitate human health.
Rapid increase in the prevalence of cannabis use among people with depression in the United States, 2005–17: the role of differentially changing risk perceptions
Authors: Pacek Lauren R. , Weinberger Andrea H. , Zhu Jiaqi , Goodwin Renee D. 
Published: December 2019

AbstractAimsTo estimate trends in the prevalence of cannabis use and risk perceptions of cannabis use from 2005 to 2017 among United States people with and without depression.DesignLinear time trends of the prevalence of any, daily and non‐daily past 30‐day cannabis use and perceived great risk associated with regular cannabis use (outcome variables) among people with and without past‐year depression were assessed using logistic regression with survey year as the predictor. All analyses were adjusted for gender, age, race/ethnicity and income; models assessing time trends of cannabis use prevalence were also adjusted for perceived risk.SettingThe United States: National Survey on Drug Use and Health, an annual cross‐sectional survey, 2005–17 public use data files.ParticipantsA total of 728 691 people aged ≥ 12 years.MeasurementsSelf‐report of any, daily and non‐daily past 30‐day cannabis use and perceived great risk associated with regular cannabis use.FindingsThe prevalence of any, daily and non‐daily cannabis use in the past month was higher among those with depression versus those without [e.g. 2017 for any use: 18.94 versus 8.67%; adjusted odds ratio (aOR) = 2.17 (95% confidence interval (CI) = 1.92, 2.45)]. Any, daily and non‐daily cannabis use increased among people with and without depression from 2005 to 2017, yet the increase in any (aORs = 1.06 versus 1.05; P = 0.008) and daily (aORs = 1.10 versus 1.07; P = 0.021) cannabis use adjusted for socio‐demographic characteristics was more rapid among those with depression. Perception of great risk associated with regular cannabis use was significantly lower among those with depression (P < 0.001) and decreased significantly more rapidly over the study period among people with depression, compared with those without (aORs = 0.89 versus 0.92; P < 0.001).ConclusionsThe prevalence of cannabis use in the United States increased from 2005 to 2017 among people with and without depression and was approximately twice as common among those with depression. People with depression experienced a more rapid decrease in perception of risk, which may be related to the more rapid increase in any and daily past‐month cannabis use in this group.
Updated guidance for the management of twin and triplet pregnancies from the National Institute for Health and Care Excellence guidance, UK: What's new that may improve perinatal outcomes?
Authors: Gibson Janice L. , Castleman James S. , Meher Shireen , Kilby Mark D. 
Published: December 2019

AbstractIn September 2019, NICE published updated guidance on the management of multiple pregnancy (NG 137). Many of the previous recommendations for care are upheld but there have been important changes: increased frequency of combined ultrasound/specialist antenatal care appointments for pregnancies containing a monochorionic placenta (twins and triplets), increased frequency of ultrasound monitoring in all triplet pregnancies, changes in the definition of selective growth restriction and its subsequent referral pathways, the introduction of some monitoring for twin (or triplet) anemia polycythemia sequence in monochorionic pregnancies (albeit in complex pregnancies or at an advanced stage), and a recommended timing of birth for any pregnancy with monoamniotic fetuses. New recommendations have been made for mode of delivery, fetal monitoring in labor, maternal analgesia, and the prevention of postpartum hemorrhage. The absence of any recommendation relating to the prevention of preterm birth is notable. The basis and implications of the updates that may improve perinatal outcomes are discussed.
The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12® in infant colic: A randomised, double blind, placebo‐controlled trial
Authors: Nocerino Rita , De Filippis Francesca , Cecere Gaetano , Marino Antonio , Micillo Maria , Di Scala Carmen , de Caro Carmen , Calignano Antonio , Bruno Cristina , Paparo Lorella , Iannicelli Anna M. , Cosenza Linda , Maddalena Ylenia , della Gatta Giusy , Coppola Serena , Carucci Laura , Ercolini Danilo , Berni Canani Roberto 
Published: December 2019

SummaryBackgroundThe pathogenesis of infant colic is poorly defined. Gut microbiota seems to be involved, supporting the potential therapeutic role of probiotics.AimsTo assess the rate of infants with a reduction of ≥50% of mean daily crying duration after 28 days of intervention with the probiotic Bifidobacterium animalis subsp. lactis BB‐12® (BB‐12). Secondary outcomes were daily number of crying episodes, sleeping time, number of bowel movements and stool consistency.MethodsRandomized controlled trial (RCT) on otherwise healthy exclusively breastfed infants with infant colic randomly allocated to receive BB‐12 (1 × 109 CFU/day) or placebo for 28 days. Gut microbiota structure and butyrate, beta‐defensin‐2 (HBD‐2), cathelicidin (LL‐37), secretory IgA (sIgA) and faecal calprotectin levels were assessed.ResultsEighty infants were randomised, 40/group. The rate of infants with reduction of ≥50% of mean daily crying duration was higher in infants treated with BB‐12, starting from the end of 2nd week. No infant relapsed when treatment was stopped. The mean number of crying episodes decreased in both groups, but with a higher effect in BB‐12 group (−4.7 ± 3.4 vs −2.3 ± 2.2, P < 0.05). Mean daily stool frequency decreased in both groups but the effect was significantly higher in the BB‐12 group; stool consistency was similar between the two groups. An increase in Bifidobacterium abundance (with significant correlation with crying time reduction), butyrate and HBD‐2, LL‐37, sIgA levels associated with a decrease in faecal calprotectin level were observed in the BB‐12 group.ConclusionsSupplementation with BB‐12 is effective in managing infant colic. The effect could derive from immune and non‐immune mechanisms associated with a modulation of gut microbiota structure and function.
Sample size and power for the weighted log‐rank test and Kaplan‐Meier based tests with allowance for nonproportional hazards
Authors: Yung Godwin , Liu Yi 
Published: December 2019

AbstractAsymptotic distributions under alternative hypotheses and their corresponding sample size and power equations are derived for nonparametric test statistics commonly used to compare two survival curves. Test statistics include the weighted log‐rank test and the Wald test for difference in (or ratio of) Kaplan‐Meier survival probability, percentile survival, and restricted mean survival time. Accrual, survival, and loss to follow‐up are allowed to follow any arbitrary continuous distribution. We show that Schoenfeld's equation—often used by practitioners to calculate the required number of events for the unweighted log‐rank test—can be inaccurate even when the proportional hazards (PH) assumption holds. In fact, it can mislead one to believe that 1:1 is the optimal randomization ratio (RR), when actually power can be gained by assigning more patients to the active arm. Meaningful improvements to Schoenfeld's equation are made. The present theory should be useful in designing clinical trials, particularly in immuno‐oncology where nonproportional hazards are frequently encountered. We illustrate the application of our theory with an example exploring optimal RR under PH and a second example examining the impact of delayed treatment effect. A companion R package npsurvSS is available for download on CRAN.