bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study between Lithium and Extended-release Carbamazepine in Acute Mania: A Double-blind Clinical Trial
Authors: Shafti Saeed S. , Kaviani Hamid 
Published: June 2020

Background:
Recently, numerous large clinical trials have been performed to evaluate the
effectiveness and tolerability of extended-release formulations of carbamazepine in bipolar disorder.

Objective:
In the current study, we compared lithium with a prolonged-release form of carbamazepine
(Tegretol CR) to evaluate its efficiency and safety in a group of patients with a diagnosis of
acute mania.

Methods:
Fifty patients with the diagnosis of acute mania were selected for a three-week, doubleblind
study, and were randomly administered lithium carbonate or tegretol CR. The main outcome
measured in the present evaluation was the Manic State Rating Scale (MSRS), which was scored at
baseline and weekly intervals up to the third week. Moreover, insight and overall illness severity and
improvement were assessed using the Schedule for Assessment of Insight (SAI), the Clinical Global
Impressions-Global Improvement scale (CGI-I), and the Clinical Global Impressions Severity Scale
(CGI-S), respectively. The statistical significance was defined with a p-value ≤0.05, and the treatment
efficacy was analyzed by independent samples t-test and repeated measures analysis of variance
(ANOVA).

Results:
Despite the fact that the mean total score of MSRS improved significantly with respect to
both lithium carbonate and tegretol CR at the end of the third week, the between-group analysis
showed a significant advantage of lithium, regarding both frequency and intensity of symptoms, at
the end of the study. The mean total score of SAI, as well, showed significant improvement caused
by both of them. Nevertheless, while the CGI-I demonstrated significant improvement in participants
taking lithium and tegretol CR, the CGI-S showed significant progress only with lithium. Besides,
Cohen’s effect size analysis showed a large improvement of MSRS by lithium and medium improvement
by tegretol CR. Post-hoc power analysis showed an intermediate power of 0.42 on behalf
of the current evaluation.

Conclusion:
While both lithium carbonate and tegretol CR were found to be valuable for the improvement
of manic symptoms, management with lithium appears to be more helpful.
Evaluation of Effectiveness of Multifactorial Lesion Field Taking into Account the Action of Incendiary Ele-ments
Authors: Kozlov V. V. , Vasilyev A. V. , Dеmсhеnко A. A. , Chuprin A. I. 
Published: June 2020

Проведенный анализ последних военных операций с применением массированного высокоточного оружия в обычном снаряжении (Югославия, Ирак, Ливия, Сирия и др.) подтверждает, что основными береговыми и морскими целями являются объекты ракетных и авиационных комплексов как потенциальные носители ядерного оружия. Спланированное поражение объектов ракетных и авиационных комплексов на земле и на море обеспечивает стратегическое превосходство. Объекты авиационных и мобильных ракетных комплексов относятся к объектам с горюченасыщенными материалами и при известном их местоположении являются весьма уязвимыми целями по отношению к совместному осколочно-огневому воздействию. При этом следует отметить, что для поражения данных целей используется и энергия самих целей, во много крат превосходящая энергию применяемого средства поражения.Сегодня осколочные и осколочно-фугасные боевые части средств поражения образуют один из самых обширных и развитых классов боеприпасов, предназначенных для поражения практически всех типов целей, однако их применение без использования зажигательных средств поражения не всегда целесообразно и эффективно. В условиях ведения боевых действий основной объем задач по поражению назначенных целей решается с высокой степенью вероятности одновременным применением осколочно-фугасных и зажигательных средств поражения. Известно, что совместное применение боеприпасов разрушительного (фугасного, осколочного и др.) и зажигательного характера эффективно с точки зрения нанесенного ущерба при условии совмещения их зон поражения. В реальных условиях организация такого комбинированного воздействия затруднена из-за значительного индивидуального рассеивания средств поражения с различными поражающими факторами.Совместное применение средств поражения разрушительно-зажигательного действия в едином боеприпасе значительно повышает их боевую эффективность, и прежде всего по объектам с горюченасыщенными материалами. Создание такого многофакторного оружия – один из безусловных приоритетов госпрограммы вооружения.Для конструирования такого оружия на начальных этапах необходимо выработать единый научный подход для оценки эффективности многофакторных полей поражения с учетом действия зажигательных элементов, которого на сегодня нет. Представлены теоретические исследования в области оценки эффективности многофакторного оружия.
Un curso de Michel Serres o el don de la palabra
Authors: Paláu Castaño Luis Alfonso 
Published: June 2020

Michel Authier
Traducción del francés al español de Luis Alfonso Paláu-Castaño
Ante nuestros ojos, el filósofo de las ciencias duras nos descubría las matemáticas en la filosofía de Leibniz, la topología en los nombres y los lugares de las novelas de Julio Verne, la estética del equilibrio del bien y el mal en los cuadros de Carpaccio, la termodinámica de la genética fatal que consume a los personajes de Zola, la comunicación que provoca la risa en las viñetas de Tintin… Entonces no sabíamos que los pozos, los puentes, los grafos presentes desde el origen en la tesis saturada de integrales, de series, de combinaciones, de infinitos grandes y pequeños, estaría aun operando para tejer, puentear, integrar los más variados conceptos. Lejos de la experticia sobre la idea, el pensamiento, el sistema de un autor que legitima al doctor en filosofía, comenzábamos a comprender que la variedad que funcionaba nos dejaba ver un filósofo.
Michel Serres, historiador de las ciencias
Authors: Paláu Castaño Luis Alfonso 
Published: June 2020

Bernadette Bensaude-Vincent.
Traducción del francés al español de Luis Alfonso Paláu-Castaño
Entre todos los títulos que se le atribuyen a Michel Serres —filósofo, escritor, académico…—, rara vez se recuerda el de historiador. Sin embargo, es el que le conviene por profesión desde que el departamento de historia de la Universidad París le confió en 1970 una cátedra de historia de las ciencias. Este aspecto de su carrera es invariablemente ocultado aunque él no tenga nada de episódico, puesto que Serres enseñó historia de las ciencias durante cerca de treinta años. Formó una generación entera de estudiantes en la Sorbona y dirigió una obra colectiva Elementos de historia de las ciencias, que sirvió de manual a gran cantidad de estudiantes durante una buena decena de años.
Hoitotyöntekijöiden näkemyksiä lääkehoidon hallintajärjestelmän tuesta ammattimaiseen ja turvalliseen lääkehoitoon
Authors: Santavirta Jenni , Kuusisto Anne , Saranto Kaija , Suominen Tarja , Asikainen Paula 
Published: June 2020

Turvallinen lääkehoito on keskeinen osa sairaanhoitajan työtä. Turvallista lääkehoitoa on tutkittu lääkitysvirheiden avulla, mutta turvallista ja ammattimaista lääkehoitoa tukevista asioista on vähemmän aiempaa tutkimustietoa. Tämän tutkimuksen tarkoituksena on kuvata hoitotyöntekijöiden näkemyksiä siitä, mikä nykyisessä lääkehoidon hallintajärjestelmässä tukee turvallista ja ammattimaista lääkehoitoa. Lääkehoidon hallintajärjestelmällä tarkoitetaan kaikkia lääkehoidon antamista ja siihen liittyviä toimenpiteitä ohjaavia ja tukevia organisaation rakenteita ja käytäntöjä.
Tutkimus toteutettiin yhdessä Suomen keskussairaalassa. Aineisto kerättiin kaksoiskäännetyn Medication Administration System – Nurses Assesment Scale (MAS - NAS) -mittarin avoimen osion ja taustakysymysten avulla. Aineisto analysoitiin induktiivisella sisällönanalyysilla.
Turvallista lääkehoitoa tuki säilytyspaikan asianmukaisuus, tarvikkeiden tarpeenmukaisuus, lisätiedon saatavuus lääkkeistä, sähköisen järjestelmän hyödyllisyys ja hyvä käytettävyys, potilaskohtaisten tietojen saatavuus, lääkityksen varmistusmahdollisuus, tarkistuskäytäntöjen ja lääkehoidon osa-alueestaan vastuun kantaminen. Ammattimaista lääkehoitoa tuki yhteistyössä toimiminen ja ajan tasalla pysyminen.
Tukeakseen turvallista lääkehoitoa johtajien tehtävänä on tarjota lääkkeille asianmukaiset säilytystilat ja hoitotyöntekijöiden käyttöön tarvittavat tarvikkeet sekä sellaiset välineet, että lääkityksessä tarvittavat tiedot ovat saatavilla ja lääkitys on mahdollista varmistaa. Tarkistuskäytännöt tulee ottaa käyttöön ja varmentaa, että kaikki tuntevat lääkehoidon vastuunsa. Sähköisen järjestelmän hyvä käytettävyys ja hyödyllisyys hoitotyöntekijöille on keskeistä turvalliselle lääkehoidolle. Ammattimaista lääkehoitoa vahvistavat tiedon jakaminen ja esimiesten kannustus yhteistyössä toimimiseen, kouluttautumiseen ja aktiiviseen tiedonhakuun.
Lääkintälaitteiden valmistajien valmistautuminen uuteen lääkintälaiteasetukseen (MDR)
Authors: Huusko Juhamatti , Kinnunen Ulla-Mari , Saranto Kaija 
Published: June 2020

Markkinoilla on enenevässä määrin lääkintälaitteita, joita käytetään potilaiden hoidossa ja potilaan itsensä suorittamassa omahoidossa. Tämä vaatii lainsäätäjiltä lainsäädännön ajantasaistamista. Lainsäädännön yksi keskeisin tarkoitus on potilasturvallisuuden varmistaminen.
Vuonna 2017 Euroopan parlamentti ja neuvosto antoivat asetuksen (2017/745) lääkintälaitteista (engl. Medical Device Regulation, MDR), joka astui voimaan toukokuussa 2017. Sen siirtymäaikaa on vuoden 2020 toukokuuhun asti, ja se korvaa aikaisemmin voimassa olleen lääkintälaitedirektiivin (93/42/ETY).
Tämän tutkimuksen tarkoituksena oli kartoittaa, minkälaista tietoa Suomessa toimivien lääkintälaitteiden valmistajilla on uudesta lääkintälaiteasetuksesta (2017/745) ja kuinka ne hankkivat lisää tietoa ennen siirtymäajan loppua. Tutkimusaineisto kerättiin kyselylomakkeella Suomessa toimivilta lääkintälaitteiden valmistajilta vuoden 2019 huhtikuussa. Kyselylomake muodostettiin Webropol-ohjelmistolla ja vastaanottajille (N=287) lähetettiin linkki kyselylomakkeeseen. Tämän lisäksi vastauslinkkiä jaettiin sosiaalisessa mediassa. Kyselyyn vastasi lääkintälaitteiden valmistajien edustajia (n=60) ympäri Suomea.
Tämä tutkimus osoitti, että tieto uuteen lääkintälaiteasetukseen (2017/745) liittyen on pirstaloitunutta ja yritykset joutuvat hakemaan tietoa useasta eri lähteestä. Yritysten mielestä tietoa on kuitenkin saatavana ja osaamisen taso on hyvää yritysten keskuudessa. Yritykset hankkivat huomattavassa määrin osaamista itsenäisesti opiskellen, mutta myös kouluttautuvat osallistumalla muun muassa Healthtech Finlandin ja regulaatiopalveluita tarjoavien asiantuntijayritysten järjestämiin koulutuksiin. Suuremmat yritykset ovat pienempiä yrityksiä paremmin valmistautuneita ja tietoisia uudesta lääkintälaiteasetuksesta (2017/745). Tämän tutkimuksen perusteella voidaan todeta, että uuden lääkintälaiteasetuksen (2017/745) alkuperäinen aikataulu oli haastava. Tähän tutkimukseen osallistuneista yrityksistä neljäsosalla oli rekisteröity lääkintälaitteita Iso-Britanniaan.
Kontribusi Keputusan Operasi dalam Pencapaian Keunggulan Bersaing Biaya Rendah (Low Cost) pada Monica Collection Semarang
Authors: Kusdiartini Veronica , Soekesi Agustine Eva Maria , Prapti Meniek Srining , Perstianto Bayu 
Published: June 2020

This research result gives contribution to Decision on Operation in achieving Low Cost Competitive Advantage in Monica Collection Semarang. Realizing this objective, it should be conducted research in operation decision supporting Monica Collection company to achieve its competitive advantage based on low cost. In this research it was found that there was operation decision conducted which supporting this low cost competitive advantage.
Las corrientes subterráneas. Un caso de estudio en las disputas por el bosque en el suroeste de la Ciudad de México. 1856-1913
Authors: Falcón Romana 
Published: June 2020

Una laguna historiográfica fundamental sobre México son los nexos entre pueblos y haciendas, donde residía el grueso de los habitantes desde la independencia y hasta la revolución del siglo XX. Este artículo explora algunas aristas destacadas de esta contradictoria relación. El escenario es una región de densos bosques del suroeste de la ciudad de México, en la cuenca del río Magdalena. La perspectiva es de historia social, la relación de leñadores, madereros, carboneros, pastores y gente del común con las haciendas circundantes. Se muestran tanto las notables continuidades desde la era novohispana como los grandes cambios, en este caso, cuando el desplome porfirista permitió a los pobladores ventilar sus agravios en voz alta y, a veces, con lujo de violencia. Resaltan las dinámicas sociales sutiles que, si bien quedaron relativamente ocultas por mucho tiempo, al caer las compuertas del orden trastocaron severamente el statu quo. La revolución entregaría a estos pueblos, en forma de ejidos, la mayor parte de los territorios forestales disputados con las haciendas. Con base en una extensa recopilación de archivos, en especial el histórico de la Ciudad de México y el Archivo General Agrario, se analizan las raíces del descontento: los derechos de uso, posesión y propiedad del bosque, tanto como los agravios personales y de carácter moral. También, los argumentos de los contendientes, mismos que enlazaban ideas y valores antiguos con otros de nuevo cuño. Un personaje clave para mantener el orden social concentró el odio popular: los administradores de haciendas con sus típicas redes caciquiles.
Pável Filónov versus Pablo Ruiz Picasso
Authors: Miguel Fernández Antonia 
Published: June 2020

Aunque el título del artículo parece aludir a la oposición entre ambos artistas, el análisis de sus vidas y obra evidencia que, aunque sus figuras son en gran medida contrapuestas, también poseen características que los unen. No obstante, dados los límites del presente trabajo, sólo vamos a detenernos en tres cuestiones: la firma, su relación con las mujeres y los retratos de familia. No nos parece adecuado tratar la cuestión atendiendo a la importancia que la posición social o su origen oriental u occidental poseen en la producción artística de uno u otro, por una cuestión en la que están de acuerdo todos los estudiosos de la obra de Filónov: su obra es tan absolutamente extraordinaria y original, que se encuentra al margen, no sólo de las vanguardias occidentales, sino de las propiamente rusas. Es un artista único, que creó un estilo único, “el arte analítico” y una escuela propia y, por tanto, sin parangón con ningún otro.
Case report: Guillain-Barré syndrome and possible association with Lyme disease
Authors: Muliuolis I. , Tilindytė E. , Samaitienė R. 
Published: June 2020

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating or axon-damaging polyneuropathy. It is characterized by sensory, motor and reflex disorder, damaged cranial nerves, autonomic disorders, and, less frequently, damage to the central nervous system. This is a life-threatening condition that urges patients to seek emergency treatment for progressive pain, paralysis and/or respiratory distress that can cause death in the absence of timely treatment. Early diagnosis and treatment of this condition are very important in preventing fatal outcome. Although many infections are associated with the etiology of GBS, correlation with Lyme disease is determined very rarely. Lyme disease is a tick-borne Borrelia burgdorferi infection that can cause lesions of multiple organ systems: usually the skin, joints, nervous system, and the heart. This case report presents an 8-year-old boy who was admitted to the hospital because of progressive weakness in the extremities, meningeal signs, bilateral facial nerve paresis, and areflexia. The patient was diagnosed with GBS and Lyme disease; and symptoms of the patient gradually disappeared following the treatment with intravenous immunoglobulin and ceftriaxone. Although the diagnosis of GBS was definite, the diagnosis of Lyme disease was complicated by a variety of circumstances which we analyse in this article. We also discuss a possible connection between the two pathologies.
Changes in the neurologists’ professional identity
Authors: Šeduikienė M. , Matonis V. 
Published: June 2020

Introduction. Neurologists’ professional identity (NPI) experiences constant changes due to rapid development of neurology innovations, whereas neither concept nor peculiarities of NPI changes have been investigated in literature, at least to the best knowledge of the authors, excluding the descriptions of some aspects of the concept.Objective. To reveal NPI peculiarities and make analysis of assumptions that can cause their changes.Tasks. To propose the definition of NPI and evaluate how both the IT and neurology innovations are impacting changes of NPI.Methods. Review of the latest literature, as well as the application of prognostic method to estimate NPI changes in future. The proposal of NPI definition is based on a variety of NPI characteristics presented in literature. Main assumptions of NPI changes are differentiated and described.After summarizing various approaches, the definition of NPT was formulated and assumptions determining the changes in NPT were identified and described. Using a predictive method based on the analysis of the impact of IT, biotechnology and medical innovations on neurology, possible future changes in NPT were discussed.Results and discussion. The results of the investigation and discussions are introduced in five paragraphs.In the first paragraph The concept of NPI, peculiarities of its formation and changes, the definition of NPI is presented and effect of NPI changes on neurologist’s sense of well-being is elucidated.In the second paragraph Development of technologies and enlargement of neurologist’s possibilities, the impact of computation and robotics on NPI changes is considered and neurologists’ preparedness to meet new challenges is examined.The third paragraph The influence of medical innovations on NPI changes explains the necessity to obtain some new competences arising from epidemic growth of chronic diseases which, in turn, increase the number of subspecialties.The fourth paragraph The impact of overlap of neurology with adjacent professions on NPI changes discloses situations where neurologists in some aspects overlap with adjacent professions and may solve some therapeutic problems that are intensively emerging in some domains of contemporary social life, such as psychedelic therapy, creation of global happiness, and enhancing student achievement.In the fifth paragraph Prognostic insights of neurology and possible changes in NPI, some discussions on possible future changes in NPI are considered.Conclusions. Key findings and essential features of the discussion are summarized in the conclusion paragraph. NPI peculiarities and factors which cause their changes are highlighted as well as it is shown how NPI content understanding may strengthen neurologist’s professional self-perception.
Risk factors and treatment approaches to seasonal affective disorder: a review
Authors: Jurgaitytė V. , Khawaja N. , Dijokas J. , Rimkevičiūtė P. 
Published: June 2020

Seasonal Affective Disorder (SAD) is a type of depression which emerges seasonally, in winter or summer. This condition affects 1-2% of the general population; however, in regions more than 30 degrees of the equator, a higher proportion (10-20%) of people suffer from SAD. There is a milder form of SAD, subsyndromal SAD (S-SAD), which is known as “winter blues”. Besides environmental risk factors, such as day length and sunlight exposure, genetics and neurochemical changes in the brain also play a role in SAD patients showing that this disorder is heterogeneous. Imbalances in the circadian rhythm and dysregulation of neurotransmitters (serotonin, dopamine, and norepinephrine) have been identified as risk factors for symptomatic SAD. SAD symptoms can be diminished by bright light therapy, regulating patients’ circadian rhythms, and cognitive-behavioural therapy, which more indirectly focuses on alleviating depressive symptoms by allowing patients to actively manage how they perceive stress and anxiety. The paper compares effectiveness and safety of treatment methods against SAD.
Factors determining the painfulness of electroneuromyography
Authors: Ališauskaitė U. , Garšvienė D. , Švilpauskė-Laurynienė J. , Ališauskienė M. 
Published: June 2020

Introduction. Electroneuromyography (ENMG) is a useful diagnostic test for the evaluation of neuromuscular disorders. The procedure is considered unpleasant or even painful due to the use of electrical stimuli and needle electrodes. In this study, we investigated the influence of demographic factors on the perception of pain during ENMG examination as well as the connection between the perception of pain and the extent of the examination, the presence of chronic pain, its characteristics, and levels of anxiety and depression in patients.Methods. 400 patients who were referred to ENMG examination participated in a questionnaire survey after the procedure. The questionnaire included rating of pain intensity experienced during ENMG procedure using numerical rating scale (NRS), basic demographic information, information about the extent of the examination, questions about previously experienced pain, and the Hospital Anxiety and Depression Scale (HADS).Results. The mean of NRS score was 3.76±2.6. There was a negative correlation between pain intensity during ENMG and education level (r=-0.12, p=0.03). There was a significant (p=0.011) correlation between the intensity of pain and the extent of ENMG examination. The procedure was more painful for the patients who experienced continuous pain before the procedure (p=0.002), and the intensity correlated with qualitative aspects of pain. There was a significant correlation between pain intensity during the examination and the emotional state of the patient (p<0.001).Conclusions. The only correlation between pain intensity and demographic factors was a negative correlation with education level. There was a significant correlation between experienced pain before the procedure and the intensity of pain during the examination. There was a significant correlation between the intensity of pain during the examination and levels of anxiety and depression.
Breast cancer metastases in central nervous system. Case report and review of literature
Authors: Radzevičiūtė I. , Pačinskaitė R. , Gleiznienė R. 
Published: June 2020

Breast cancer is the most frequently diagnosed cancer among women worldwide. The most common first site of distant spread is bone, followed by lung, brain, and liver. Symptoms of meta- static breast cancer can vary greatly depending on the location of the metastases. Symptoms of metastases of breast cancer in the brain, depending on location, can include nausea, headache, hemiparesis, blurred vision, seizures, slurred speech, impaired thinking, dizziness. Breast carcinoma tends to metastasize to the cerebellum and the basal ganglia. A very aggressive intraventricular, leptomeningeal spread to the central nervous system is also possible; however, it is a rare localization of breast cancer metastasis. Magnetic resonance imaging (MRI) is the most sensitive diagnostic tool for the detection of brain metastases. Treatment approaches of brain metastases include surgery, stereotactic radiosurgery (SRS), and whole brain radiation therapy (WBRT). In this article we present a case of a 34-year-old woman with a clinical diagnosis of breast cancer and metastases to the central nervous system. The patient received treatment at the stereotactic radiosurgery centre Sigulda in Latvia; during the course of the disease, intraventricular metastatic spread to the brain was diagnosed. In addition, the article also reviews the literature on the clinical presentation of intracerebral breast cancer metastases, diagnosis, and treatment recommendations.