bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Xylinas’ nomogram accurately predict intravesical recurrence risk after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma when applied to Asian populations?
Authors: Lai Shicong , Wu Pengjie , Diao Tongxiang , Seery Samuel , Liu Jianyong , Hou Huimin , Liu Ming , Wang Jianye 
Published: July 2020

Abstract

Objective
To validate a prognostic nomogram (Xylinas’ nomogram) for intravesical recurrence after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma patients of Asian descent.

Methods
Clinicopathological and survival data from 243 primary urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy with bladder cuff excision between January 2004 and May 2017 were collated. Univariate and multivariable Cox regression analyses were performed to identify independent risk factors associated with intravesical recurrence-free survival. External validation was determined using regression coefficients abstracted from previously published data. Performance was then quantified through calibration and discrimination, according to concordance indexes (c-index) in receiver operating characteristic curves.

Results
163 patients met our eligibility criteria and were finally included in this study. At a median follow-up of 60 months, intravesical recurrence occurred in 29.4% (n = 48). Multivariable analysis revealed that being male, ureteral tumor location, tumor multifocality and previous bladder cancer were independent prognostic factors of intravesical recurrence-free survival. When Xylinas’ nomogram was applied to our cohort, the discriminatory power was found to be roughly equivalent with a c-index of 68.3% for the reduced model and 68.4% for the full model. Calibration plots also revealed intravesical recurrence predictions at 3, 6, 12, 18, 24 and 36 months had relative concordance. Contrasting the respective performances of the reduced and full model suggests there is no significant difference between the two (all P &gt; 0.05).

Conclusions
This nomogram appears accurate at predicting intravesical recurrence after radical nephroureterectomy for primary urinary tract urothelial carcinoma in Asian populations. However, it remains necessary to data mine for unknown prognostic factors for optimization. Further external validation is required across larger, ethically diverse populations before applying this nomogram in clinical practice.
A Note on Chromy’s Sampling Procedure
Authors: Chauvet Guillaume 
Published: July 2020

AbstractChromy (1979) proposed an unequal probability sampling algorithm, which is the default sequential method used in the SURVEYSELECT procedure of the SAS software. In this article, we demonstrate that Chromy sampling is equivalent to pivotal sampling. This makes it possible to estimate the variance unbiasedly for the randomized version of the method programmed in the SURVEYSELECT procedure.
Binary black holes in the pair instability mass gap
Authors: Di Carlo Ugo N , Mapelli Michela , Bouffanais Yann , Giacobbo Nicola , Santoliquido Filippo , Bressan Alessandro , Spera Mario , Haardt Francesco 
Published: July 2020

ABSTRACT
Pair instability (PI) and pulsational PI prevent the formation of black holes (BHs) with mass ≳60 M⊙ from single star evolution. Here, we investigate the possibility that BHs with mass in the PI gap form via stellar mergers and multiple stellar mergers, facilitated by dynamical encounters in young star clusters. We analyse 104 simulations, run with the direct N-body code nbody6++gpu coupled with the population synthesis code mobse. We find that up to ∼6 per cent of all simulated BHs have mass in the PI gap, depending on progenitor’s metallicity. This formation channel is strongly suppressed in metal-rich (Z = 0.02) star clusters because of stellar winds. BHs with mass in the PI gap are initially single BHs but can efficiently acquire companions through dynamical exchanges. We find that ∼21 per cent, 10 per cent, and 0.5 per cent of all binary BHs have at least one component in the PI mass gap at metallicity Z = 0.0002, 0.002, and 0.02, respectively. Based on the evolution of the cosmic star formation rate and metallicity, and under the assumption that all stars form in young star clusters, we predict that ∼5 per cent of all binary BH mergers detectable by advanced LIGO and Virgo at their design sensitivity have at least one component in the PI mass gap.
The magnetic obliquity of accreting T Tauri stars
Authors: McGinnis Pauline , Bouvier Jérôme , Gallet Florian 
Published: July 2020

ABSTRACT
Classical T Tauri stars (CTTSs) accrete material from their discs through their magnetospheres. The geometry of the accretion flow strongly depends on the magnetic obliquity, i.e. the angle between the rotational and magnetic axes. We aim at deriving the distribution of magnetic obliquities in a sample of 10 CTTSs. For this, we monitored the radial velocity variations of the He i λ5876 Å line in these stars’ spectra along their rotational cycle. He i is produced in the accretion shock, close to the magnetic pole. When the magnetic and rotational axes are not aligned, the radial velocity of this line is modulated by stellar rotation. The amplitude of modulation is related to the star’s projected rotational velocity, vsin i, and the latitude of the hotspot. By deriving vsin i and He i λ5876 radial velocity curves from our spectra, we thus obtain an estimate of the magnetic obliquities. We find an average obliquity in our sample of 11.4° with an rms dispersion of 5.4°. The magnetic axis thus seems nearly, but not exactly aligned with the rotational axis in these accreting T Tauri stars, somewhat in disagreement with studies of spectropolarimetry, which have found a significant misalignment (≳20°) for several CTTSs. This could simply be an effect of low number statistics, or it may be due to a selection bias of our sample. We discuss possible biases that our sample may be subject to. We also find tentative evidence that the magnetic obliquity may vary according to the stellar interior and that there may be a significant difference between fully convective and partly radiative stars.
The SAMI–Fornax Dwarfs Survey I: sample, observations, and the specific stellar angular momentum of dwarf elliptical galaxies
Authors: Scott Nicholas , Eftekhari F Sara , Peletier Reynier F , Bryant Julia J , Bland-Hawthorn Joss , Capaccioli Massimo , Croom Scott M , Drinkwater Michael , Falcón-Barroso Jésus , Hilker Michael , Iodice Enrichetta , Lorente Nuria F P , Mieske Steffen , Spavone Marilena , van de Ven Glenn , Venhola Aku 
Published: July 2020

ABSTRACT
Dwarf ellipticals are the most common galaxy type in cluster environments; however, the challenges associated with their observation mean that their formation mechanisms are still poorly understood. To address this, we present deep integral field observations of a sample of 31 low-mass (107.5 &lt; M⋆ &lt; 109.5 M⊙) early-type galaxies in the Fornax cluster with the SAMI instrument. For 21 galaxies, our observations are sufficiently deep to construct spatially resolved maps of the stellar velocity and velocity dispersion – for the remaining galaxies, we extract global velocities and dispersions from aperture spectra only. From the kinematic maps, we measure the specific stellar angular momentum λR of the lowest mass dE galaxies to date. Combining our observations with early-type galaxy data from the literature spanning a large range in stellar mass, we find that λR decreases towards lower stellar mass, with a corresponding increase in the proportion of slowly rotating galaxies in this regime. The decrease of λR with mass in our sample dE galaxies is consistent with a similar trend seen in somewhat more massive spiral galaxies from the CALIFA survey. This suggests that the degree of dynamical heating required to produce dEs from low-mass starforming progenitors may be relatively modest and consistent with a broad range of formation mechanisms.
On the survival of resonant and non-resonant planetary systems in star clusters
Authors: Stock Katja , Cai Maxwell X , Spurzem Rainer , Kouwenhoven M B N , Portegies Zwart Simon 
Published: July 2020

ABSTRACT
Despite the discovery of thousands of exoplanets in recent years, the number of known exoplanets in star clusters remains tiny. This may be a consequence of close stellar encounters perturbing the dynamical evolution of planetary systems in these clusters. Here, we present the results from direct N-body simulations of multiplanetary systems embedded in star clusters containing N = 8k, 16k, 32k, and 64k stars. The planetary systems, which consist of the four Solar system giant planets Jupiter, Saturn, Uranus, and Neptune, are initialized in different orbital configurations, to study the effect of the system architecture on the dynamical evolution of the entire planetary system, and on the escape rate of the individual planets. We find that the current orbital parameters of the Solar system giants (with initially circular orbits, as well as with present-day eccentricities) and a slightly more compact configuration, have a high resilience against stellar perturbations. A configuration with initial mean-motion resonances of 3:2, 3:2, and 5:4 between the planets, which is inspired by the Nice model, and for which the two outermost planets are usually ejected within the first 105 yr, is in many cases stabilized due to the removal of the resonances by external stellar perturbation and by the rapid ejection of at least one planet. Assigning all planets the same mass of 1 MJup almost equalizes the survival fractions. Our simulations reproduce the broad diversity amongst observed exoplanet systems. We find not only many very wide and/or eccentric orbits, but also a significant number of (stable) retrograde orbits.
SRG/eROSITA uncovers the most X-ray luminous quasar at z &gt; 6
Authors: Medvedev P , Sazonov S , Gilfanov M , Burenin R , Khorunzhev G , Meshcheryakov A , Sunyaev R , Bikmaev I , Irtuganov E 
Published: July 2020

ABSTRACT
We report the discovery of X-ray emission from CFHQS J142952+544717, the most distant known radio-loud quasar at z = 6.18, on 2019 December 10–11 with the eROSITA telescope on board the SRG satellite during its ongoing all-sky survey. The object was identified by cross-matching an intermediate SRG/eROSITA source catalogue with the Pan-STARRS1 distant quasar sample at 5.6 &lt; z &lt; 6.7. The measured flux ∼8 × 10−14 erg cm−2 s−1 in the 0.3–2 keV energy band corresponds to an X-ray luminosity of $2.6^{+1.7}_{-1.0}\times 10^{46}$ erg s−1 in the 2–10 keV rest-frame energy band, which renders CFHQS J142952+544717 the most X-ray luminous quasar ever observed at z &gt; 6. Combining our X-ray measurements with archival and new photometric measurements in other wavebands (radio to optical), we estimate the bolometric luminosity of this quasar at ∼(2–3) × 1047 erg s−1. Assuming Eddington limited accretion and isotropic emission, we infer a lower limit on the mass of the supermassive black hole of ∼2 × 109 M⊙. The most salient feature of CFHQS J142952+544717 is its X-ray brightness relative to the optical/UV emission. We argue that it may be linked to its radio-loudness (although the object is not a blazar according to its radio properties), specifically to a contribution of inverse Compton scattering of cosmic microwave background photons off relativistic electrons in the jets. If so, CFHQS J142952+544717 might be the tip of the iceberg of high-z quasars with enhanced X-ray emission, and SRG/eROSITA may find many more such objects during its 4-yr all-sky survey.
Spatiotemporal Genetic Diversity of Lions Reveals the Influence of Habitat Fragmentation across Africa
Authors: Curry Caitlin J , Davis Brian W , Bertola Laura D , White Paula A , Murphy William J , Derr James N 
Published: July 2020

AbstractDirect comparisons between historical and contemporary populations allow for detecting changes in genetic diversity through time and assessment of the impact of habitat fragmentation. Here, we determined the genetic architecture of both historical and modern lions to document changes in genetic diversity over the last century. We surveyed microsatellite and mitochondrial genome variation from 143 high-quality museum specimens of known provenance, allowing us to directly compare this information with data from several recently published nuclear and mitochondrial studies. Our results provide evidence for male-mediated gene flow and recent isolation of local subpopulations, likely due to habitat fragmentation. Nuclear markers showed a significant decrease in genetic diversity from the historical (HE = 0.833) to the modern (HE = 0.796) populations, whereas mitochondrial genetic diversity was maintained (Hd = 0.98 for both). Although the historical population appears to have been panmictic based on nDNA data, hierarchical structure analysis identified four tiers of genetic structure in modern populations and was able to detect most sampling locations. Mitogenome analyses identified four clusters: Southern, Mixed, Eastern, and Western and were consistent between modern and historically sampled haplotypes. Within the last century, habitat fragmentation caused lion subpopulations to become more geographically isolated as human expansion changed the African landscape. This resulted in an increase in fine-scale nuclear genetic structure and loss of genetic diversity as lion subpopulations became more differentiated, whereas mitochondrial structure and diversity were maintained over time.
Development of a gene expression–based prognostic signature for IDH wild-type glioblastoma
Authors: Johnson Radia M , Phillips Heidi S , Bais Carlos , Brennan Cameron W , Cloughesy Timothy F , Daemen Anneleen , Herrlinger Ulrich , Jenkins Robert B , Lai Albert , Mancao Christoph , Weller Michael , Wick Wolfgang , Bourgon Richard , Garcia Josep 
Published: July 2020

Abstract

Background
We aimed to develop a gene expression–based prognostic signature for isocitrate dehydrogenase (IDH) wild-type glioblastoma using clinical trial datasets representative of glioblastoma clinical trial populations.

Methods
Samples were collected from newly diagnosed patients with IDH wild-type glioblastoma in the ARTE, TAMIGA, EORTC 26101 (referred to as “ATE”), AVAglio, and GLARIUS trials, or treated at UCLA. Transcriptional profiling was achieved with the NanoString gene expression platform. To identify genes prognostic for overall survival (OS), we built an elastic net penalized Cox proportional hazards regression model using the discovery ATE dataset. For validation in independent datasets (AVAglio, GLARIUS, UCLA), we combined elastic net–selected genes into a robust z-score signature (ATE score) to overcome gene expression platform differences between discovery and validation cohorts.

Results
NanoString data were available from 512 patients in the ATE dataset. Elastic net identified a prognostic signature of 9 genes (CHEK1, GPR17, IGF2BP3, MGMT, MTHFD1L, PTRH2, SOX11, S100A9, and TFRC). Translating weighted elastic net scores to the ATE score conserved the prognostic value of the genes. The ATE score was prognostic for OS in the ATE dataset (P &lt; 0.0001), as expected, and in the validation cohorts (AVAglio, P &lt; 0.0001; GLARIUS, P = 0.02; UCLA, P = 0.004). The ATE score remained prognostic following adjustment for O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status and corticosteroid use at baseline. A positive correlation between ATE score and proneural/proliferative subtypes was observed in patients with MGMT non-methylated promoter status.

Conclusions
The ATE score showed prognostic value and may enable clinical trial stratification for IDH wild-type glioblastoma.
Value of dynamic contrast perfusion MRI to predict early response to bevacizumab in newly diagnosed glioblastoma: results from ACRIN 6686 multicenter trial
Authors: Schmainda Kathleen M , Prah Melissa A , Marques Helga , Kim Eunhee , Barboriak Daniel P , Boxerman Jerrold L 
Published: July 2020

Abstract

Background
In Radiation Therapy Oncology Group (RTOG) 0825, a phase III trial of standard therapy with bevacizumab or without (placebo) in newly diagnosed glioblastoma, 44 patients underwent dynamic contrast enhanced (DCE) and/or dynamic susceptibility contrast (DSC) MRI in the American College of Radiology Imaging Network (ACRIN) trial 6686. The association between early changes in relative cerebral blood volume (rCBV) and volume transfer constant (Ktrans) with overall survival (OS) was evaluated.

Methods
MRI was performed at postop baseline (S0), immediately before (S1), 1 day after (S2), and 7 weeks after (S3) bevacizumab or placebo initiation. Mean normalized and standardized rCBV (nRCBV, sRCBV) and Ktrans were measured within contrast-enhancing lesion. Wilcoxon rank sum tests compared parameter changes from S1–S2 and S1–S3. Association with OS and progression-free survival (PFS) were determined using Kaplan–Meier and log-rank tests. Treatment response for groups stratified by pretreatment nRCBV (S0, S1) was explored. The intraclass correlation coefficient and repeatability coefficient for the placebo arm (S1–S2) were used to assess repeatability.

Results
Evaluable were 27–36 datasets per time point. Significant differences between treatment arms were found for changes in nRCBV and sRCBV from S1–S2 and S1–S3, and in Ktrans for S1–S3. Improved PFS (P = 0.05) but not OS (P = 0.46) was observed. High pretreatment rCBV predicted improved OS for bevacizumab-treated patients. Based on the intraclass correlation coefficient, sRCBV (0.92) was more repeatable than nRCBV (0.71) and Ktrans (0.75), consistent with repeatability coefficient values.

Conclusions
Bevacizumab significantly changes rCBV but not Ktrans as early as 1 day posttreatment in newly diagnosed glioblastoma unrelated to outcomes. Improvements in clinical trial design to maximize rCBV benefit are indicated.
Learning Delegation Through Role-Play: A Problem-Based Learning Activity for Nursing Students
Authors: Seibert Susan A. 
Published: July 2020

Abstract
According to the American Nurses Association and National Council of State Boards of Nursing 2019 guidelines, teaching strategies are needed to engage students in the application of delegation knowledge and skills. Students need opportunities to gain experience with delegation decision-making in a safe, risk-free environment. This article describes the instructional design and evaluation of an innovative role-play activity to engage senior-level nursing students in delegation decision-making.
Suicide Behavior Following PHQ-9 Screening Among Individuals With Substance Use Disorders
Authors: Yarborough Bobbi Jo H. , Stumbo Scott P. , Ahmedani Brian , Rossom Rebecca , Coleman Karen , Boggs Jennifer M. , Simon Gregory E. 
Published: July 2020

Objectives:
Individuals with substance use disorders (SUD) are at risk for suicide, but no studies have assessed whether routinely administered screeners for suicidal ideation accurately identify outpatients with SUD who are at risk for suicide attempt or death.

Methods:
Data from more than 186,000 visits by over 55,000 patients with mental health and SUD diagnoses receiving care in 7 health systems were analyzed to determine whether responses to item 9 of the 9-item Patient Health Questionnaire, which assesses frequency of thoughts of death and self-harm, are associated with suicide outcomes after an outpatient visit. Odds of suicide attempt or death were computed using generalized estimating equations.

Results:
In bivariate analyses, a nearly 5-fold risk was observed for patients answering “nearly every day” relative to “not at all” among individuals who made a suicide attempt within 90 days (4.9% vs 1.1%; χ2 = 1151, P < 0.0001). At nearly half of visits (46%) followed by a suicide attempt within 90 days, patients responded “not at all.” In logistic models, compared to “not at all,” all other responses were associated with higher odds of suicide attempt or death within 90 days. Fully adjusted models attenuated results but odds of suicide attempt (AOR = 3.24, CI: 2.69–3.91) and suicide death (AOR = 5.67, CI: 2.0–16.1) remained high for those reporting “nearly every day.”

Conclusions:
In people with SUD, increasing Patient Health Questionnaire item 9 response predicts increased risk of subsequent suicidal behavior and should prompt intervention. However, clinicians should realize that those reporting “not at all” are not immune from subsequent suicide risk.
Recent Trends and Overall Survival of Young Versus Older Adults With Stage II to III Rectal Cancer Treated With and Without Surgery in the United States, 2010-2015
Authors: Sanford Nina N. , Dee Edward C. , Ahn Chul , Kazmi Syed A. , Beg Muhammad S. , Folkert Michael R. , Aguilera Todd A. , Polanco Patricio M. , Pogacnik Javier S. , Sher David J. 
Published: July 2020

Background:
The omission of surgery via nonoperative management (NOM) for rectal cancer may be increasing, and this strategy could be particularly attractive for younger patients, whose incidence of rectal cancer has been rising. We sought to assess trends in NOM in young (younger than 55 y) versus older adult (55 y and older) rectal cancer cohorts.

Methods:
The National Cancer Database was used to identify patients diagnosed with stage II to III rectal cancer between 2010 and 2015. Multivariable logistic regression defined the association between sociodemographic variables and odds of NOM, including an age (18 to 54 vs. 55+ y)×surgery (surgery vs. NOM) interaction term. Adjusted Cox regression models compared overall survival between NOM versus surgery.

Results:
Among 22,561 patients with a median follow-up of 37.5 months, the utilization rate of NOM increased from 10.7% (2010) to 15.2% (2015). Older patients were more likely to receive NOM, although rates also increased among young (7.1% to 10.6%). Black patients were also more likely to receive NOM (P<0.001). Among the entire cohort, NOM was associated with worse overall survival (adjusted hazard ratio [AHR]=2.90, 95% confidence interval [CI]: 2.67-3.15) and there was a statistically significant age×NOM interaction (P=0.01) such that the effect of NOM on survival was worse for younger (AHR=3.37, 95% CI: 2.82-4.02) as compared with older patients (AHR=2.49, 95% CI: 2.27-2.74).

Conclusions:
The increasing trend for NOM in stage II to III rectal cancer may be driven by disparities in treatment. Management with NOM appears to be associated with poorer survival, particularly in younger patients and could worsen outcomes for groups already at risk for suboptimal cancer care.