bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐specific prevalence and determinants of depression in long‐term breast cancer survivors compared to female population controls
Authors: Doege Daniela , Thong Melissa S. Y. , Koch‐Gallenkamp Lena , Jansen Lina , Bertram Heike , Eberle Andrea , Holleczek Bernd , Pritzkuleit Ron , Waldmann Annika , Zeissig Sylke R. , Brenner Hermann , Arndt Volker 
Published: October 2020

AbstractBackgroundDepression is more prevalent in breast cancer (BC) survivors than in the general population. However, little is known about depression in long‐term survivors. Study objectives were: (1) to compare the age‐specific prevalence of depressive symptoms (a) in BC survivors vs female population controls, (b) in disease‐free BC survivors vs BC survivors with self‐reported recurrence vs controls, and (2) to explore determinants of depression in BC survivors.MethodsAbout 3010 BC survivors (stage I‐III, 5‐16 years post‐diagnosis), and 1005 population controls were recruited in German multi‐regional population‐based studies. Depression was assessed by the Geriatric Depression Scale‐15. Prevalence of mild/severe and severe depression only were estimated via logistic regression, controlling for age and education. Multinomial logistic regression was used to explore determinants of mild and severe depression.ResultsCompared with population controls, BC survivors were more likely to report mild/severe depression (30.4% vs 23.8%, p = .0003), adjusted for age and education. At all age groups <80 years, prevalence of both mild/severe and severe depression only was significantly higher in BC survivors, while BC survivors ≥80 years reported severe depression less frequently than controls. BC survivors with recurrence reported significantly higher prevalence of mild/severe depression than disease‐free survivors and controls, but prevalence in disease‐free survivors and controls was comparable. Age, income, living independently, recurrence, and BMI were significant determinants of mild depression in BC survivors. Age, education, employment, income, recurrence, and BMI were significant determinants of severe depression.ConclusionsLong‐term BC survivors <80 years report significantly higher prevalence of depressive symptoms than controls, which might be explained by recurrence and individual factors. The findings suggest that depression in BC survivors is common, and even more after BC recurrence. Clinicians should routinize screening and normalize referral to psychological care.
C‐Terminal Tag Location Hampers in Vitro Profiling of OGT Peptide Substrates by mRNA Display
Authors: Shi Jie , Sharif Suhela , Balsollier Cyril , Ruijtenbeek Rob , Pieters Roland J. , Jongkees Seino A. K. 
Published: October 2020

AbstractO‐GlcNAc transferase (OGT) is the only enzyme that catalyzes the post‐translational modification of proteins at Ser/Thr with a single β‐N‐acetylglucosamine (O‐GlcNAcylation). Its activity has been associated with chronic diseases such as cancer, diabetes and neurodegenerative disease. Although numerous OGT substrates have been identified, its accepted substrate scope can still be refined. We report here an attempt to better define the peptide‐recognition requirements of the OGT active site by using mRNA display, taking advantage of its extremely high throughput to assess the substrate potential of a library of all possible nonamer peptides. An antibody‐based selection process is described here that is able to enrich an OGT substrate peptide from such a library, but with poor absolute recovery. Following four rounds of selection for O‐GlcNAcylated peptides, sequencing revealed 14 peptides containing Ser/Thr, but these were shown by luminescence‐coupled assays and peptide microarray not to be OGT substrates. By contrast, subsequent testing of an N‐terminal tag approach showed exemplary recovery. Our approach demonstrates the power of genetically encoded libraries for selection of peptide substrates, even from a very low initial starting abundance and under suboptimal conditions, and emphasizes the need to consider the binding biases of antibodies and both C‐ and N‐terminal tags in profiling peptide substrates by high‐throughput display.
Synthesis and Coordination Behavior of a New Hybrid Bidentate Ligand with Phosphine and Silylene Donors
Authors: Nazish Mohd , Siddiqui Mujahuddin M. , Kumar Sarkar Samir , Münch Annika , Legendre Christina M. , Herbst‐Irmer Regine , Stalke Dietmar , Roesky Herbert W. 
Published: October 2020

AbstractThis work describes the synthesis and coordination behavior of a new mixed‐donor ligand PhC(NtBu)2SiC6H4PPh2 (1) containing both silylene and phosphine donor sites. Ligand 1 was synthesized from a reaction of ortho‐lithiated diphenylphosphinobenzene (LiC6H4PPh2) with chlorosilylene (PhC(NtBu)2SiCl). Treatment of 1 with Se and GeCl2 resulted in SiIV compounds 2 and 3 by selective oxidation of the silylene donor. This strong σ‐donor ligand induces dissociation of CuCl and PhBCl2 leading to formation of ionic complexes 4 and 5 respectively. The reaction of 1 with ZnCl2 and AlCl3 resulted in the formation of chelate complexes 5 and 7, respectively, while treatment with EtAlCl2 and GaCl3 forms monodentate complexes 8 and 9. X‐ray analysis of 4 showed that the copper is in the spiro center of the two five‐membered rings. Moreover, the copper(I)chloride has not been oxidized but dissociates to Cu+ and [CuCl2]−. All the compounds are well characterized by mass spectrometry, elemental analysis, NMR spectroscopy, and single‐crystal X‐ray diffraction studies.
Enhanced Stability and Emission Properties of Perylene Dyes by Surface Tethering: Preparation of Fluorescent Ru Nanoparticle Suspensions by Alkyne Linker Chemistry
Authors: Morais Eduardo , Moloney Cara , O'Modhrain Colin , McKiernan Eoin , Brougham Dermot F. , Sullivan James A. 
Published: October 2020

AbstractSpherical ruthenium nanoparticles (NPs) with a narrow size distribution were synthesised in ethanol by a facile low‐temperature solvothermal process without the assistance of templates, structure‐directing agents or post annealing/reduction treatments. Surface passivation with a fluorescent perylene dye (EP), and with silane ligands (ETMS), both initially bearing alkyne groups and subsequently forming vinylidene linkages, provided stable suspensions of the marginally soluble free EP. Quantitative analysis of the suspension gave an estimated EP surface coverage of 15 %, corresponding to an EP/ETMS mole ratio of ≈1:6. Photophysical evaluation of the bound and free dye revealed similar absorption bands and extinction coefficients and improved properties for the bound state, including enhanced fluorescence in the visible range for the bound dye, an extended absorption range into the near‐UV providing strong emission in the visible, and significantly improved photostability. The physical basis of the enhanced photophysical properties, potential routes to further improvements and the implications for applications are discussed.
Excited State Dynamics of Isolated 6‐ and 8‐Hydroxyquinoline Molecules
Authors: Mestdagh Jean‐Michel , Poisson Lionel 
Published: October 2020

AbstractThe photoinduced dynamics of isolated n‐hydroxyquinoline (nHQ) molecules (n=6,8) was investigated in femtosecond pump‐probe experiments. A qualitative difference was found between 8HQ and 6HQ. After an initial rapid decay corresponding to the departure of the initial wavepacket out of the Franck‐Condon region of the excitation, the 8HQ probe signal decays to zero in 0.37 ps whereas a much longer time constant of 10.4 ps is observed in 6HQ. This interrogates on the role played by the intramolecular H‐bond N
HO which is at play the 8HQ molecule. Ab‐initio were performed at the MCSCF/aug‐cc‐pVDZ level on the 8HQ molecule to help the discussion. A complex energy landscape was found, which includes a conical intersection.
Individualized Dosing of Fluoropyrimidine‐Based Chemotherapy to Prevent Severe Fluoropyrimidine‐Related Toxicity: What Are the Options?
Authors: Knikman Jonathan E. , Gelderblom Hans , Beijnen Jos H. , Cats Annemieke , Guchelaar Henk‐Jan , Henricks Linda M. 
Published: October 2020

Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although most often well tolerated, severe toxicity is encountered in ~ 20–30% of the patients. Individualized dosing for these patients can reduce the incidence of severe fluoropyrimidine‐related toxicity. However, no consensus has been achieved on which dosing strategy is preferred. The most established strategy for individualized dosing of fluoropyrimidines is upfront genotyping of theDPYDgene. Prospective research has shown thatDPYD‐guided dose‐individualization significantly reduces the incidence of severe toxicity and can be easily applied in routine daily practice. Furthermore, the measurement of the dihydropyrimidine dehydrogenase (DPD) enzyme activity has shown to accurately detect patients with a DPD deficiency. Yet, because this assay is time‐consuming and expensive, it is not widely implemented in routine clinical care. Other methods include the measurement of pretreatment endogenous serum uracil concentrations, the uracil/dihydrouracil‐ratio, and the 5‐fluorouracil (5‐FU) degradation rate. These methods have shown mixed results. Next to these methods to detect DPD deficiency, pharmacokinetically guided follow‐up of 5‐FU could potentially be used as an addition to dosing strategies to further improve the safety of fluoropyrimidines. Furthermore, baseline characteristics, such as sex, age, body composition, and renal function have shown to have a relationship with the development of severe toxicity. Therefore, these baseline characteristics should be considered as a dose‐individualization strategy. We present an overview of the current dose‐individualization strategies and provide perspectives for a future multiparametric approach.
Town mediation in Taiwan
Authors: Hera Gabor 
Published: October 2020

AbstractThe primary aim of this paper is to demonstrate the ways in which historical roots and social context have had an impact on mediation in Taiwan. During the investigation, the history, legal environment, and everyday practice of mediation were analyzed with particular attention to an out‐of‐court alternative dispute resolution method: town mediation. As the findings of a literature review and the qualitative field work confirm, town mediation only adheres to some principles of professionalism, and only to a limited extent. However, some specific features of town mediation that successfully contribute to peaceful conflict resolution are also discussed.
Organizational ambidexterity, green entrepreneurial orientation, and environmental performance in SMEs context: Examining the moderating role of perceived CSR
Authors: Shafique Imran , Kalyar Masood Nawaz , Mehwish Nadia 
Published: October 2020

AbstractThis study aims to investigate the effects of organizational ambidexterity and green entrepreneurial orientation (GEO) on the environmental performance of small‐ and medium‐sized enterprises (SMEs). Drawing upon social capital theory (SCT), this study suggests corporate social responsibility (CSR) as an important context that moderates the organizational ambidexterity–GEO nexus. Data were collected from 307 Pakistani manufacturing SMEs and analyzed through partial least squares (PLS)‐based structural equation modeling (SEM). The results provided empirical evidence in support of the study's hypotheses. The findings imply that the complexity and difficulty firms face in achieving environmental performance can be reduced through simultaneous exploration and exploitation of innovation as well as and through GEO. Furthermore, the effectiveness of ambidexterity in prompting GEO and subsequent environmental performance can be optimized as long as firms are capable of creating a suitable context, that is, CSR.
Keggin‐type Heteropolyacids‐Catalyzed Selective Hydrothermal Oxidation of Microalgae for Low Nitrogen Biofuel Production
Authors: Shen Zhensheng , Long Feiping , Ma Tian , Li Huan , Li An , Feng Qian , Liu Jiuyi , Sun Yingqiang 
Published: October 2020

AbstractHydrothermal liquefaction (HTL) of microalgae for biofuel production is suffering from low bio‐oil yield and high heteroatomic compositions owing to their low efficiency and selectivity to hydrolysis of cellular compounds. Hereby we report Keggin‐type (Mo−V−P) heteropolyacids (HPAs)‐catalyzed HTL of microalgae for efficient low‐nitrogen biocrude production. The increases of reaction temperature, reaction time, and vanadium substitution degrees of HPAs are favorable to biocrude yield initially, whereas a significant decrease of biocrude yield is observed owing to the enhanced oxidation of carbohydrates above the optimum reaction conditions. The maximum biocrude yield of HPAs‐catalyzed HTL of microalgae is 29.95 % at reaction temperature of 300 °C, reaction time of 2 h, and 5 wt% of HPA‐4, which is about 19.66 % higher than that of control with 71.17 % less N‐containing compounds, including 1,3‐propanediamine, 1‐pentanamine, and 2, 2’‐heptamethylene‐di‐2‐imidazoline than that of control. This work reveals that HPAs with Brønsted acidity and reversible redox properties are capable of both enhancing biocrude production via catalyzing the hydrolysis of cellular compounds and reducing their nitrogen content through avoiding the Maillard reactions between the intermediates of hydrolysis of carbohydrates and proteins. HPAs‐catalyzed HTL is an efficient strategy to produce low N‐containing biofuels, possibly paving the way of their direct use in modern motors.
Unlocking the Potential of Substrate‐Directed CO2 Activation and Conversion: Pushing the Boundaries of Catalytic Cyclic Carbonate and Carbamate Formation
Authors: Limburg Bart , Cristòfol Àlex , Della Monica Francesco , Kleij Arjan W. 
Published: October 2020

AbstractThe unparalleled potential of substrate‐induced reactivity modes in the catalytic conversion of carbon dioxide and alcohol or amine functionalized epoxides is discussed in relation to more conventional epoxide/CO2 coupling strategies. This conceptually new approach allows for a substantial extension of the substitution degree and functionality of cyclic carbonate/carbamate products, which are predominant products in the area of nonreductive CO2 transformations. Apart from the creation of an advanced library of CO2‐based heterocyclic products and intermediates, also the underlying mechanistic reasons for this novel reactivity profile are debated with a prominent role for the design and structure of the involved catalysts.
Genetic differentiation underlies seasonal variation in thermal tolerance, body size, and plasticity in a short‐lived copepod
Authors: Sasaki Matthew C. , Dam Hans G. 
Published: October 2020

AbstractOrganisms experience variation in the thermal environment on several different temporal scales, with seasonality being particularly prominent in temperate regions. For organisms with short generation times, seasonal variation is experienced across, rather than within, generations. How this affects the seasonal evolution of thermal tolerance and phenotypic plasticity is understudied, but has direct implications for the thermal ecology of these organisms. Here we document intra‐annual patterns of thermal tolerance in two species of Acartia copepods (Crustacea) from a highly seasonal estuary, showing strong variation across the annual temperature cycle. Common garden, split‐brood experiments indicate that this seasonal variation in thermal tolerance, along with seasonal variation in body size and phenotypic plasticity, is likely affected by genetic polymorphism. Our results show that adaptation to seasonal variation is important to consider when predicting how populations may respond to ongoing climate change.
Critical appraisal of the instantaneous end‐diastolic pulmonary arterial wedge pressures
Authors: Manouras Aristomenis , Lund Lars H. , Gellér László , Nagy Anikó Ilona , Johnson Jonas 
Published: October 2020

AbstractAimsA substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported. Instead, aiming for a better estimate of end‐diastolic pressures (EDP), instantaneous PAWP at mid‐A‐wave (PAWPmid‐A) or, in the absence of an A‐wave, at 130–160 ms following QRS onset has recently been recommended. Electrocardiogram‐gated PAWP (PAWPQRS) has also been proposed. The quantitative differences as well as the diagnostic and prognostic utility of these novel PAWP measurements have not been evaluated. We set out to address these issues.Methods and resultsPressure tracings of 141 patients with PH due to left heart disease (PH‐LHD) and 43 with primary pulmonary arterial hypertension (PAH) were analysed. PAWP was measured as follows: (i) mean pressure (PAWPM); (ii) per the latest consensus approach [PAWPmid‐A, or in atrial fibrillation 130, 140, 150, and 160 ms following QRS onset (PAWP130–160)]; (iii) at QRS onset (PAWPQRS); and (iv) Z‐point (PAWPZ). For each PAWP, the corresponding pulmonary vascular resistance (PVR) and diastolic pressure gradient were calculated. The cohort comprised 45% female. Mean age was 66 ± 15. PAWPmid‐A was in good agreement with PAWPZ (17.3 [14.5 to 21.2] vs. 17.6 [14.2 to 21.6] mmHg, P = 0.63), whereas PAWPQRS provided significantly lower values (15.3 [12.5 to 19.2] mmHg, P < 0.001). In atrial fibrillation, PAWP130 and PAWPQRS yielded the optimal temporal and quantitative analyses of EDPs. The ability to differentiate PAH from PH‐LHD was similar for the various PAWP measurements [PAWPM: area under the curve (AUC) 0.98, confidence interval (CI) 0.96–0.99; PAWPmid‐A/130: AUC 0.94, CI 0.91–0.98; PAWPQRS: AUC 0.96, CI 0.94–0.99, P < 0.001 for all]. PVR based on instantaneous PAWP measurements failed to provide superior prognostic information in PH‐LHD as compared with conventional PVR.ConclusionsAlthough instantaneous PAWP measurement might better represent EDP, they nevertheless fail to yield incremental diagnostic or prognostic information in PH‐LHD as compared with conventional measurements.
Capillary zone electrophoresis of proteins applying ionic liquids for dynamic coating and as background electrolyte component
Authors: Mező Emerencia , Páger Csilla , Makszin Lilla , Kilár Ferenc 
Published: October 2020

AbstractThe use of ionic liquids in capillary electrophoresis, either as coating material or as components of the background electrolyte needs systematic standardization to set up optimal conditions. Excellent separation of the proteins was achieved using 1‐ethyl‐3‐methylimidazolium tetrafluoroborate ([emim][BF4]) or 1‐butyl‐3‐methylimidazolium tetrafluoroborate ([bmim][BF4]) ionic liquids using the properly made ionic‐liquid–water binary mixtures for the experiments. The binary mixture has a distinctly stable and well perceptible low pH, which depends on the concentration of the ionic liquid, and on the preparation time of the mixture. Optimal conditions for the electrophoretic separation were obtained upon a multivariate analysis of the experimental parameters (applied voltage, migration time, concentration, and type of the ionic liquid). The standardized condition provides a low electroendosmotic flow toward the anode, which, however, did not hinder the proteins to migrate toward the cathode. The migration of cytochrome c, lysozyme, myoglobin, trypsin, and apo‐transferrin at a pH around 2, far below the isoelectric points of the proteins, showed RSD values of the migration times less than 7.5% and less than 6.5% when using [emim][BF4] or [bmim][BF4], respectively, either in run‐to‐run or day‐to‐day experiments. The determination of the extent of the EOF is not possible with the commonly used EOF markers, due to interaction with the ionic‐liquid constituents. The interaction of the ionic liquids with the proteins influences the migration order in zone electrophoresis. This method has been applied successfully for the analyses of real biological samples such as proteins from egg whites and human tears.
Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
Authors: Sun Zhe , Seo Ji Won , Park Hong Ju , Lee Jee Yeon , Kwak Min Young , Kim Yehree , Lee Je Yeon , Park Jun Woo , Kang Woo Seok , Ahn Joong Ho , Chung Jong Woo , Kim Hosung 
Published: October 2020

AbstractLong‐term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients who underwent cochlear implantation and 37 patients who were MRI‐scanned within 2 weeks after the onset of sudden hearing loss and expected with minimal brain structural changes in relation to deafness. Compared with those with sudden hearing loss, we found lower gray matter (GM) probabilities in bilateral thalami, superior, middle, inferior temporal cortices as well as the central cortical regions corresponding to the movement and sensation of the lips, tongue, and larynx in the PD group. Among these brain areas, the GM in the middle temporal cortex showed negative correlation with disease duration, whereas the other areas displayed positive correlations. Left superior, middle temporal cortical, and bilateral thalamic GMs were the most accurate predictors of post‐cochlear implantation word recognition scores (mean absolute error [MAE] = 10.1, r = .82), which was superior to clinical variables used (MAE: 12.1, p < .05). Using the combined brain morphological and clinical features, we achieved the best prediction of the outcome (MAE: 8.51, r = .90). Our findings suggest that the cross‐modal plasticity allowing the superior temporal cortex and thalamus to process other modal sensory inputs reverses the initially lower volume when deafness becomes persistent. The middle temporal cortex processing higher‐level language comprehension shows persistent negative correlations with disease duration, suggesting this area's association with degraded speech comprehensions due to long‐term deafness. Morphological features combined with clinical variables might play a key role in predicting outcomes of cochlear implantation.
Total Synthesis of (−)‐Rotundone and (−)‐epi‐Rotundone from Monoterpene Precursors
Authors: Rüthi Fabian , Schröder Fridtjof 
Published: October 2020

AbstractThe first total synthesis of (−)‐rotundone has been accomplished from (+)‐(R)‐limonene and therefore for the first time from an unrelated monoterpene instead of modifying structurally closely related sesquiterpene precursors such as α‐guaiene. Challenges such as intermediates with stereocenters prone to epimerization by enolization were overcome by designing a β‐methyl‐keto route starting from (+)‐(R)‐limonene which finally gave (−)‐rotundone by Nazarov cyclization of a precursor 13a. Diastereomer (−)‐epi‐rotundone was separated from (−)‐rotundone chromatographically. An alternative route from rac‐citronellal provided a diastereomer mixture of racemic Nazarov precursor 13 through a TRIP‐catalyzed intramolecular aldolization, thus indicating that the Nazarov cyclization precursor 13a is in principle accessible from (−)‐(S)‐citronellal. The 11‐step synthesis from (+)‐(R)‐limonene with ca. 1 % overall yield confirmed the absolute configuration of (−)‐rotundone and provided samples of good olfactory quality.