bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of interleukins 12B and 17A genetic variation in house dust mites allergy
Authors: Ammar Asmaa Mostafa , EL. Zayyat Elham Abbas , Khayyal Amira EL. Saady , Hamdy Dina Mamdouh , EL-Gendy Aya , Elleboudy Noha Abdel Fattah 
Published: November 2020

Abstract
Background
The house dust mites (HDM) constitute a major cause of allergic diseases all over the world. Genes encoding interleukins 12B and 17A which determine the course of T cell-mediated immune response are prime candidates as allergic disease susceptibility. The purpose of this study was to evaluate whether a single-nucleotide polymorphisms (SNP) of interleukins 12B + 1188A/C (rs3212227) and 17A −197G/A (rs2275913) confers susceptibility to HDM allergic diseases. Through a case-control study, 120 subjects served as 60 dust mites' allergic patients and 60 healthy non-allergic controls. Total immunoglobulin (Ig) E level, eosinophilic count, serum interleukins 4, 10, 12B, and 17A levels for the studied subjects were measured. Then, genotyping of single-nucleotide polymorphisms (SNPs) at +1188A/C for IL12B and −197G/A for IL17A gene were conducted using restriction fragment length polymorphisms (RFLP-PCR).

Results
The present study showed that in HDMs' allergic subjects there was a significant increase in IL12B (+1188 A/C) and IL17A (−197 G/A) genotype variants compared to that of the controls. There was a significant increase in total IgE levels, eosinophil counts, and the levels of both IL-4 and IL-17A, while IL12B was significantly lower in patients compared to that of the controls. There was no significant difference in IL-10 levels between patients and controls.

Conclusion
Our findings indicate that IL12B (+1188 A/C) and IL17A (−197G/A) might be associated with an increase in the susceptibility to dust mites’ allergic patients.
Arterial spin labeling in the grading of brain gliomas: could it help?
Authors: ElBeheiry Ahmed A. , Emara Doaa M. , Abdel-Latif Amany Abdel-Bary , Abbas Mohamed , Ismail Amal S. 
Published: November 2020

Abstract
Background
Gliomas are characterized by high morbidity and mortality with low cure and high recurrence rates, which depends to a great degree on the angiogenesis of the tumor. Assessment of such angiogenesis by perfusion techniques is of utmost importance for the preoperative grading of gliomas. The purpose of this study was to assess the role of arterial spin labeling (ASL) perfusion as a non-contrast MRI technique in the grading of brain gliomas, in correlation with the dynamic susceptibility contrast perfusion imaging (DSC-PI). The study was carried out on 35 patients admitted to the Neurosurgery Department with MRI features of gliomas and sent for further perfusion imaging. Non-contrast ASL followed by DSC-PI was done for all cases. The final diagnosis of the cases was established by histopathology.

Results
Fourteen patients (14/35) had low-grade gliomas while twenty-one (21/35) had high-grade gliomas. In low-grade gliomas, four cases out of 14 were falsely graded as high-grade tumors showing hyperperfusion on ASL, three of which showed DSC-PI hypoperfusion. In high-grade gliomas, two cases out of 21 were interpreted as an indeterminate grade by ASL showing isoperfusion, however showed hyperperfusion on DSC-PI. ROC curve analysis showed ASL-derived rCBF > 2.08 to have 80.95% sensitivity, 85.71% specificity, and overall accuracy of 82.86% compared to 100% sensitivity, specificity, and accuracy of DSC-PI-derived rCBV and rCBF of > 1.1 and > 0.9, respectively. A significant positive correlation was noted between ASL and DSC-PI with correlation coefficient reaching r = 0.80 between ASL-rCBF and DSC-rCBF (p < 0.01) and r = 0.68 between ASL and DSC-rCBV (p < 0.01).

Conclusions
ASL is a relatively recent non-contrast perfusion technique that obtains results which are in fair agreement with the more established DSC perfusion imaging making it an alternative method for preoperative assessment of perfusion of gliomas, especially for patients with contraindications to contrast agents.
SISTEM INFORMASI PELAYANAN MASYARAKAT BERBASIS ANDROID PADA KANTOR DESA KALIBA MAMASE
Authors: Ritnawati Ritnawati , Suppa Rinto , Muhallim Muhlis 
Published: November 2020

The problem in this thesis research is how to design an Android-Based Community Service Information System at the KalibaMamase Village office. Information Systems for Community Services are based on the system using Black Box Testing and the accuracy of the information system is based on user testing. The research objective is to design and build a Village-level Community Service Information System in order to improve the quality of services for village staff and the use of services for local villagers. The benefit obtained from this research is to make a new innovation for each village to be able to facilitate serving residents or residents in the application for letters. This research uses the life cycle model of the Waterfall system development and the design of an Android-based population service information system. Data collection methods in this study use the method of observation, interviews, and data analysis. The conclusion of the research is that the Community Service Information System can facilitate the process of correspondence services in the Village apparatus as well as the use of services for the community in managing population and obtaining information at the Village Office. In the Android-Based Community Service Information System at the Kaliba Mamase Village Office
Communicating the risk of contracting Zika virus to low income underserved pregnant Latinas: A clinic-based study
Authors: Ramisetty-Mikler Suhasini , Boyce LeAnn 
Published: November 2020

ObjectiveFrequent travel between the Southern border states in the USA, Mexico, and Latin American countries increases the risk of the Zika virus (ZIKV) spread. Patient education on virus transmission is fundamental in decreasing the number of imported cases, particularly among pregnant women.MethodsThe study used cross-sectional methodology to investigate information sources and knowledge concerning the ZIKV virus among 300 under-served pregnant Latinas recruited from prenatal care clinics in the North Texas region. Bivariate and multiple logistic regression models were used to investigate associations between the primary outcomes and patient characteristics.ResultsPhysicians, nurses, and families are the major sources for pregnancy information, while media/internet (65%) and physician/nurse (33%) are the main sources for ZIKV information. Less than one-half of the mothers reported that their physician/nurse did not discuss safe sexual practices or inquired about their sexual practices. A considerable proportion of women from the community clinic were neither warned nor queried about travel to ZIKV risk countries. There is an overall understanding of Zika virus transmission, symptoms, complications, and recommended guidelines. Younger age and single mother status are risk factors for lack of ZIKV knowledge. Foreign-born mothers are 2.5–3.0 times more likely to have knowledge on disease transmission, symptoms, and microcephaly condition. While, younger mothers (18–24) are less likely to have knowledge of ZIKV infection symptoms (fever, rash and pink eye) and transmission of infection via unprotected sexual (vaginal, anal, or oral) behavior, compared to older mothers.ConclusionsInterventions are needed to heighten the knowledge of ZIKV, particularly among women of reproductive age and their male partners in the community health care setting. Our study underscores the need for health care providers to be trained in delivering messages to enhance risk perception during health emergencies to vulnerable and underserved families (lower economic background, language ability, and culture). During health emergencies, clinics must disseminate crucial information via multi modalities to ensure messages reach the targeted patients.
The long-term effect of short point of care ultrasound course on physicians’ daily practice
Authors: Tuvali Ortal , Sadeh Re'em , Kobal Sergio , Yarza Shaked , Golan Yael , Fuchs Lior 
Published: November 2020

Background
The benefits of Point of Care Ultrasound (POCUS) are well established in the literature. As it is an operator-dependent modality, the operator is required to be skilled in obtaining and interpreting images. Physicians who are not trained in POCUS attend courses to acquire the basics in this field. The effectiveness of such short POCUS courses on daily POCUS utilization is unknown. We sought to measure the change in POCUS utilization after practicing physicians attended short POCUS courses.

Methods
A 13-statements questionnaire was sent to physicians who attended POCUS courses conducted at the Soroka University Medical Center between the years 2014–2018. Our primary objective was to compare pre-course and post-course POCUS utilization. Secondary objectives included understanding the course graduates’ perceived effect of POCUS on diagnosis, the frequency of ultrasound utilization and time to effective therapy.

Results
212 residents and specialists received the questionnaire between 2014–2018; 116 responded (response rate of 54.7%). 72 (62.1%) participants were male, 64 (55.2%) were residents, 49 (42.3%) were specialists, 3 (2.5%) participants did not state their career status. 90 (77.6%) participants declared moderate use or multiple ultrasound use six months to four years from the POCUS course, compared to a rate of ‘no use at all’ and ‘minimal use of 84.9% before the course. 98 participants [84.4% CI 77.8%, 91.0%] agree and strongly agree that a short POCUS course may improve diagnostic skills and 76.7% [CI 69.0%, 84.3%] agree and strongly agree that the POCUS course may shorten time to diagnosis and reduce morbidity.

Conclusions
Our short POCUS course significantly increases bedside ultrasound utilization by physicians from different fields even 4 years from course completion. Course graduates strongly agreed that incorporating POCUS into their clinical practice improves patient care. Such courses should be offered to residents and senior physicians to close the existing gap in POCUS knowledge among practicing physicians.
Hospital admissions during Covid-19 lock-down in Germany: Differences in discretionary and unavoidable cardiovascular events
Authors: Stöhr Elisabeth , Aksoy Adem , Campbell Meghan , Al Zaidi Muntadher , Öztürk Can , Vorloeper Julia , Lange Jonas , Sugiura Atsushi , Wilde Nihal , Becher Marc Ulrich , Diepenseifen Christian , Heister Ulrich , Nickenig Georg , Zimmer Sebastian , Tiyerili Vedat 
Published: November 2020

Background
A decline in hospitalization for cardiovascular events and catheter laboratory activation was reported for the United States and Italy during the initial stage of the Covid-19 pandemic of 2020. We report on the deployment of emergency services for cardiovascular events in a defined region in western Germany during the government-imposed lock-down period.

Methods
We examined 5799 consecutive patients who were treated by emergency services for cardiovascular events during the Covid-19 pandemic (January 1 to April 30, 2020), and compared those to the corresponding time frame in 2019. Examining the emergency physicians’ records provided by nine locations in the area, we found a 20% overall decline in cardiovascular admissions.

Results
The greatest reduction could be seen immediately following the government-imposed social restrictions. This reduction was mainly driven by a reduction in discretionary admissions for dizziness/syncope (-53%), heart failure (-38%), exacerbated COPD (-28%) and unstable angina (-23%), while unavoidable admissions for ST-elevation myocardial infarction (STEMI), cardiopulmonary resuscitation (CPR) and stroke were unchanged. There was a greater decline in emergency admissions for patients ≥60 years. There was also a greater reduction in emergency admissions for those living in urban areas compared to suburban areas.

Conclusions
During the Covid-19 pandemic, a significant decline in hospitalization for cardiovascular events was observed during the government-enforced shutdown in a predefined area in western Germany. This reduction in admissions was mainly driven by “discretionary” cardiovascular events (unstable angina, heart failure, exacerbated COPD and dizziness/syncope), but events in which admission was unavoidable (CPR, STEMI and stroke) did not change.
El racismo y la expansión de las fronteras del autoritarismo en América latina
Authors: Ocoró Loango Anny 
Published: November 2020

El presente artículo reflexiona sobre cuatro fronteras de la exclusión que hoy ocupan un lugar central en nuestra región, y que se relacionan y retroalimentan entre sí: las fronteras de la desigualdad y la exclusión; las fronteras del racismo en América Latina; el avasallamiento de las fronteras de los territorios y culturas de los pueblos indígenas y afrodescendientes; y las fronteras del autoritarismo en expansión. En el contexto actual, se está expandiendo en algunos países de la región un discurso autoritario de la mano de la extrema derecha, y de sectores conservadores y religioso-evangélicos, que se sirve del racismo para blindar sus privilegios y para intentar construir hegemonía cultural a través de la propagación de discursos de odio. Con el fin de discutir estos cuatro ejes, priorizaré una perspectiva étnico-racial que partirá de una mirada a las poblaciones negras o afrodescendientes que habitan en América Latina, y que constituyen, junto a los pueblos indígenas, las poblaciones más castigadas por la desigualdad en esta región.
Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults
Authors: Chen Xi , Cassady Kaitlin E. , Adams Jenna N. , Harrison Theresa M. , Baker Suzanne L. , Jagust William J. 
Published: November 2020

Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex, which may reflect the beginning of Alzheimer's disease (AD). Functional connectivity between the anterolateral EC and the anterior-temporal (AT) memory network appears to drive higher tau deposition in AT than in the posterior-medial (PM) memory network. Here, we investigated whether this differential vulnerability to tau deposition may predict different cognitive consequences of EC, AT, and PM tau. Using18F-flortaucipir (FTP) and11C-Pittsburgh compound-B (PiB) positron emission tomography (PET) imaging, we measured tau and Aβ in 124 cognitively normal human older adults (74 females, 50 males) followed for an average of 2.8 years for prospective cognition. We found that higher FTP in all three regions was individually related to faster memory decline, and that the effects of AT and PM FTP, but not EC, were driven by Aβ+ individuals. Moreover, when we included all three FTP measures competitively in the same model, only AT FTP significantly predicted memory decline. Our data support a model whereby tau, facilitated by Aβ, transits from EC to cortical regions that are most closely associated with the anterolateral EC, which specifically affects memory in the initial stage of AD. Memory also appears to be affected by EC tau in the absence of Aβ, which may be less clinically consequential. These findings may provide clarification of differences between normal aging and AD, and elucidate the transition between the two stages.SIGNIFICANCE STATEMENTTau and β-amyloid (Aβ) are hallmarks of Alzheimer's disease (AD) but are also found in cognitively normal people. It is unclear whether, and how, this early deposition of tau and Aβ may affect cognition in normal aging and the asymptomatic stage of AD. We show that tau deposition in the entorhinal cortex (EC), which is common in advanced age, predicts memory decline in older adults independent of Aβ, likely reflecting normal, age-related memory loss. In contrast, tau in anterior-temporal (AT) regions is most predictive of memory decline in Aβ+ individuals. These data support the idea that tau preferentially spreads to specific cortical regions, likely through functional connections, which plays a primary role in memory decline in the early stage of AD.
Evolusi Insurjensi di Era Modern
Authors: Hapsari Sekar 
Published: November 2020

Insurgensi merupakan kata yang memberikan arti tentang gerakan yang dilakukan guna menggulingkan rezim yang sedang berkuasa, atau rezim yang telah terbentuk termasuk para pejabat yang telah terpilih secara sah dan kuat secara hukum. Departemen pertahanan AS memberikan pengertian, insurjensi sebagai gerakan terorganisir yang memiliki tujuan menggulingkan pemerintah melalui subversi dan konflik bersenjata. Ia juga dapat diartikan sebagai perjuangan berlarut larut yang dilakukan secara metodis, langkah demi langkah dalam rangka mencapai tujuan tertentu yang mengarah pada penggulingan tatanan yang ada menjadi tidak ada, yang dapat menjadi prediksi dari lahirnya revolusi.
Perusahaan Leasing dan Debt Collector Dalam Penagihan Kredit Macet Kendaraan Debitur
Authors: Atikah Ika 
Published: November 2020

Beragam produk kendaraan yang ditawarkan oleh perusahaan motor dan mobil, telah memberikan ketertarikan masyarakat perkotaan untuk segera memiliki kendaraan yang menjadi idaman mereka. Barang mewah tersebut bukan lagi sesuatu yang aneh untuk dimiliki oleh mereka yang membutuhkan kendaraan guna mobilitas sehari-hari. Munculnya produsen kendaraan tentu saja menjadi ladang bagi perusahaan leasing bekerja sama memberikan fasilitas kemudahan angsuran dengan biaya ringan kepada debitur yang hendak memiliki kendaraan namun terbatas keuangannya. Setelah proses perkreditan berlangsung, tidak jarang debitur malah lalai memenuhi kewajiban membayar angsuran tiap bulan sebagaimana perjanjian perusahaan leasing, sehingga perusahaan mau tidak mau harus menarik kendaraan debitur untuk melunasi angsurannya tersebut dengan bantuan debt-collector.
Meneguhkan Kembali Indonesia Sebagai Negara Hukum Pancasila
Authors: Rahmatullah Indra 
Published: November 2020

Abstract: The Indonesian state law based on Pancasila is a concept that has a special character distinguishing from the original concept of the Rechstaat and Rule of Law developed in western countries. These special characters include; the principle of kinship that prioritizes public interest over individual interest, the law is based on certainty and justice, the state is based on religion but not theocracy and secular systems, the law is the reflection of community culture, the law must be neutral and universal. Therefore, Pancasila is not only a spirit in the state but also a source of all sources of law in Indonesia.Keywords:State Law, Special Character and Pancasila. Abstrak:Negara Hukum Indonesia yang bersendikan Pancasila adalah sebuah konsep yang memiliki karakter khusus sehingga membedakan dari konsep aslinya yaitu Rechstaat dan Rule of Law yang berkembang di negara-negara barat. Karakter khusus tersebut di antaranya yaitu; asas kekeluargaan yang mengutamakan kepentingan umum di atas kepentingan individu, hukum yang bersendikan kepastian dan keadilan, bersendikan agama tetapi bukan teokrasi dan sekuler, hukum sebagai cermin budaya masyarakat dan hukum yang bersifat netral dan universal. Dengan demikian, Pancasila bukan hanya menjadi ruh dalam bernegara tetapi juga menjadi sumber dari segala sumber hukum di Indonesia. Kata Kunci: Negara hukum, Karakter Khusus dan Pancasila.
Urgensi Assesment Report Dalam Omnibus Law RUU Cipta Kerja
Authors: Rahmatullah Indra 
Published: November 2020

Abstract:A draft law must be able to answer and solve the main problem of the society so that with the existence of the law the community gets legal protection from the state. However, the draft of Cipta Kerja Law makes an endless controversy. In fact, the draft was allegedly containing some problems since its appearance. Therefore, academic research (Assesment Report) is needed so that the rules in the draft have basic scientific arguments that can be justified. Unfortunately, the draft does not conduct an assesment report to know whether the society need the law and urgent.Keywords: Legal Protection, Controversy and Assesment Report Abstrak:Sebuah rancangan undang-undang harus dapat menjawab dan menyentuh pokok permasalahan masyarakat sehingga dengan adanya undang-undang tersebut masyarakat mendapatkan sebuah perlindungan hukum dari negara. Namun, dalam RUU Cipta Kerja ini justru berakibat pada kontroversi yang tiada hentinya. Bahkan, disinyalir RUU ini mengandung kecacatan sejak awal pembentukannya. Oleh karena itu, dibutuhkan penelitian akademis sehingga aturan-aturan yang ada dalam RUU ini mempunyai basis argumentasi ilmiah yang dapat dipertanggungjawabkan yang salah satunya adalah dengan membuat Laporan Kelayakan. Sayangnya RUU ini belum melakukan laporan kelayakan apakah RUU ini dibutuhkan dan penting di masyarakat.Katakunci: Perlindungan Hukum, Kontroversi dan Laporan Kelayakan
Systemic Reformulation of Labour Arrangements Between Demand and Pressure Concerning Income towards Welfare in Indonesia
Authors: Sulaiman Abdullah 
Published: November 2020

AbstractsThe abstract of this article authors several points, among others:Firstly, Purpose of Article; to analyze labour regulation concerning income provision towards welfare for employers in Indonesia. Secondly, Scope of Work; that the legal implementation focuses on Indonesian labor law arrangements, and then concerning pressures relevant to income as international standard for laborers, and demand for wage acceptance as facility for labor welfare, and also labor law dispute settlement in Indonesian welfare system. Thirdly, Legal Methodology; refers to qualitative research with secondary materials from normative and empirical sources, also by conducting legal comparison from other countries outside of Indonesia. Fourthly, Result Summary; pertaining to systemic implementation of Indonesian labour regulation as stipulated in written constitution, that ”Each citizen shall reserve the rights for adequate employment and income based on sustainable standards (Article 27 paragraph (2), 1945 Indonesian Constitution). The income pressure for International labour standards via ILO has created a standard system to protect the rights of labourers binding themselves in an agreement, based on ILO Convention No.89 Year 1949 which instigated the birth of Law Number 18 Year 1956 concerning Ratification of ILO Convention No. 80 Year 1957. Demands for income to be accepted as labour welfare has yet to reiterate the importance of wage component in applicable labor law (Law Number 13 Year 2003 concerning Employment) since it allows Governor in each province to regulate the measurement of labour’s wage on annual basis. Similarly with labor trial pattern which only allows Industrial Relations Court and not solely referring to labour arbitration institution as expected from ILO and WTO as international organizations. Fifthly, Conclusion; that systemic reformulation of labour regulation in order to achive welfare in Indonesia still requires the participation or internal demand from labourers and pressure from international labour institution. Keywords: Income Regulation, Indonesian Labour Welfare.
Reconstruction of Political Party Membership In the Indonesian House of Representatives
Authors: Cahyawati Dwi Putri , Saragih Bintan 
Published: November 2020

Abstrak:Dewan Perwakilan Rakyat (selanjutnya disebut DPR) merupakan lembaga perwakilan rakyat, yang merupakan perwujudan dari ketentuan Pasal 1 Ayat (2) Undang-Undang Dasar Negara Republik Indonesia Tahun 1945. Secara sosiologis keberadaan DPR sebagai wakil rakyat merupakan amanat dari seluruh rakyat Indonesia yang harus dijalankan. Dalam praktek ketatanegaraan Indonesia, peran DPR sebagai lembaga perwakilan rakyat diwujudkan dalam bentuk fraksi, yang merupakan perpanjangan tangan partai politik dan lembaga DPR. Fraksi dibentuk dengan maksud untuk mengoptimalkan fungsi, tugas, dan wewenang DPR.Keyword: DPR, Partai Politik, Pemilu