bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing light‐harvesting chlorophyll a/b‐binding proteins for multiple abiotic stress tolerance in Chlamydomonas reinhardtii: Insights from genomic and physiological analysis
Authors: Raza Ali , Li Yiran , Rizwan Hafiz Muhammad , Khan Asadullah , Peng Yuqi , Guo Chunli , Hu Zhangli 
Published: December 2024

AbstractLight‐harvesting chlorophyll a/b‐binding proteins (LHC) of photosystem II perform key functions in various processes, e.g., photosynthesis, development, and abiotic stress responses. Nonetheless, comprehensive genome‐wide investigation of LHC family genes (CrLHCs) has not been well‐reported in single‐cell alga (Chlamydomonas reinhardtii). Here, we discovered 61 putative CrLHC genes in the C. reinhardtii genome and observed that most genes demonstrate stable exon‐intron and motif configurations. We predicted five phytohormones‐ and six abiotic stress‐interrelated cis‐regulatory elements in promoter regions of CrLHC. Likewise, 19 miRNAs targeting 42 CrLHC genes from 16 unique families were discovered. Besides, we identified 400 transcription factors from 13 families, including ERF, GATA, CPP, bZIP, C3H, MYB, SBP, Dof, bHLH, C2H2, G2‐like, etc. Protein–protein interactions and 3D structures provided insight into CrLHC proteins. Gene ontology and KEGG‐based enrichment advocated their role in light responses, photosynthesis, and energy metabolisms. Expression analysis highlighted the shared and unique roles of many CrLHC genes against different abiotic stresses (UV‐C, green light, heat, nitric oxide, cadmium, nitrogen starvation, and salinity). Under salinity stress, antioxidant enzyme activity, reactive oxygen species markers, photosynthesis‐related traits and pigments were significantly affected. Briefly, this comprehensive genomic and physiological study shed light on the impact of CrLHC genes in abiotic stress tolerance and set the path for future genetic engineering experiments.
The Razian Response to Philosophical Anarchism: A Probe into the Authority‐Autonomy Tension
Authors: Gur Noam 
Published: December 2024

AbstractThis paper juxtaposes two conflicting positions on the justifiability of authority: Robert Wolff's philosophical anarchist argument and a response to Wolff consisting in Joseph Raz's service conception of authority. Following an introduction, I provide a brief exposition of Wolff's claim that authority is incompatible with moral autonomy (Section 2). After presenting the Razian response (Section 3), I consider what implications follow from Raz's service conception of authority assuming it is correct (Section 4). I argue that, even if the service conception successfully meets the anarchist challenge, it does so not by entirely dissolving the tension between authority and autonomy, but through a balancing act whereby one aspect of our autonomy gives way to another aspect of our autonomy. Finally, I consider the service conception of authority itself and point out certain vulnerabilities thereof (Section 5).
Identification of the Novel HLA‐DRB3*02:185 Allele by Next‐Generation Sequencing in a Post‐Transplant Renal Patient
Authors: Zhao He , Webster Destinie , Gorkoff Karey , Shoker Ahmed , Mostafa Ahmed 
Published: December 2024

ABSTRACTThe novel allele HLA‐DRB3*02:185 differs from HLA‐DRB3*02:02:01:02 by one nucleotide substitution in codon 191 of exon 4.
Identification of the Novel HLA‐DPA1*02:143 Allele by Next‐Generation Sequencing
Authors: Lee Jong Kwon , Eom Sohyeon , Park Jun Woo , Lee Jina , Kang Eun‐Suk 
Published: December 2024

ABSTRACTHLA‐DPA1*02:143 is identical to HLA‐DPA1*02:02:02:01 except for a single nucleotide substitution in exon 1.
Ocular findings in dogs and cats following chemical injury by the Bronze Orange Bug (Musgraveia sulciventris)
Authors: Yates Kelly Lisa , Robertson Kate Conway , Crowe Yvette Cherie , Billson Francis Mark 
Published: December 2024

AbstractObjectiveTo describe the ocular findings in dogs and cats after chemical injury by the Bronze Orange Bug (Musgraveia sulciventris), which is endemic to eastern Australia in Queensland and New South Wales.Animals StudiedMedical records were reviewed for the keywords “stink bug” between February 2013 and January 2023. Signalment, clinical signs, month at presentation, and affected eye(s) were recorded. Cases were divided into confirmed and suspected cases.ResultsTwenty‐four confirmed and nine suspected cases were identified, consisting of 26 dogs and seven cats. There were 19 females (57.6%) and 14 males (42.4%). Median age at presentation was 1.9 (range 0.16–12.5) years, with a median weight of 6.1 (range 1.3–25) kilograms. All cases presented between August and May, with the majority (75.7%) presenting in summer. This correlates with the breeding life cycle of the Bronze Orange Bug. Unilateral presentation was more common (97%; n = 32) than bilateral (3%; n = 1) with an increased incidence of left eyes (60.6%; n = 20) compared to right eyes (36.4%; n = 12). Presenting signs included acute onset blepharospasm (100%), superficial corneal ulceration (90.9%), conjunctival hyperemia (87.8%), chemosis (60.6%), periocular swelling (51.5%), conjunctival ulceration (39.4%), third eyelid protrusion (39.4%), miosis (36.4%), corneal edema (36.4%), and aqueous flare (24.2%). The median time to resolution of clinical signs was 13 days.ConclusionsThe Bronze Orange Bug's defensive secretion causes acute onset ocular irritation consistent with acidic chemical burns in dogs and cats. Bronze Orange Bug exposure should be considered as a differential diagnosis in endemic areas, particularly during the summer months.
StepIdeator: Utilizing Mixed Representations to Support Step-By-Step Design With Generative Artificial Intelligence
Authors: Yao Jiayi , Chen Pei , Li Zhuoshu , Cai Yichen , Wu Yexinrui , You Weitao , Sun Lingyun 
Published: December 2024

Abstract
In the product conceptual design, designers utilize multiple design representations to ideate, externalize, and refine concepts iteratively. Mixed representations, defined as the simultaneous presentation of multiple representations, foster deeper insights and facilitate broader exploration compared to focusing on a single representation. However, designers often struggle with the cumbersome process of creating, transforming, and refining these representations. Advanced artificial intelligence (AI) capabilities now significantly lower the barriers to creating text, images, and 3D models, presenting substantial potential for application in design practice. However, the current design tools based on generative AI tend to produce polished product images directly, hindering designers from continuously deliberating on mixed representations and thus limiting their creative potential. Therefore, on the basis of a formative study, we propose StepIdeator, a step-by-step design tool driven by generative AI. This tool facilitates seamless transition and refinement of mixed-design representations. Through a comparative study (N = 16), we validated StepIdeator's effectiveness in improving idea externalization and enhancing creativity. Furthermore, the results revealed that designers perceived greater confidence, ownership, and sense of contribution when collaborating with StepIdeator.
Clinical significance of toxin EIA positivity in patients with suspected
Clostridioides difficile
infection: systematic review and meta-analysis
Authors: Tansarli Giannoula S. , Falagas Matthew E. , Fang Ferric C. 
Published: December 2024

ABSTRACT

The laboratory diagnosis of
Clostridioides difficile
infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/EIA−) is uncertain. PubMed and EMBASE were searched for studies reporting clinical outcomes in NAAT+/EIA− versus NAAT+/EIA+ patients. Forty-six studies comprising 33,959 patients were included in this meta-analysis. All-cause mortality (RR 0.96, 95% CI 0.80–1.15), attributable mortality (RR 0.61, 95% CI 0.20–1.91), fulminant CDI (RR 0.83, 95% CI 0.57–1.20), radiographic evidence of CDI (RR 0.87, 95% CI 0.65–1.16), total CDI complications (RR 0.95, 95% CI 0.59–1.53), colectomies (RR 0.78, 95% CI 0.34–1.79), and ICU admission (RR 1.04, 95% CI 0.84–1.30) did not significantly differ between NAAT+/EIA− and NAAT+/EIA+ patients. However, rates of recurrent (RR 0.62, 95% CI 0.50–0.77) or severe (RR 0.74, 95% CI 0.63–0.88) CDI were significantly lower in NAAT+/EIA− patients than in NAAT+/EIA+ patients. The pooled prevalence of NAAT+/EIA− patients who were treated with antibiotics for CDI was 73.4% (pooled proportion 0.72, 95% CI 0.52–0.88). NAAT+/EIA− patients have lower rates of recurrence and are at reduced risk for severe CDI compared with NAAT+/EIA+ patients but have a risk of CDI-related complications and mortality comparable to that of NAAT+/EIA+ patients. Toxin results cannot rule in or rule out CDI, and the decision whether to treat symptomatic NAAT+/EIA− patients for CDI should be based on clinical presentation and not on the toxin result.

IMPORTANCE

Clostridioides difficile
infection (CDI) is a common cause of healthcare-associated infections and the leading cause of antibiotic-associated diarrhea. However, the laboratory diagnosis of CDI, primarily done by nucleic acid amplification test (NAAT) and enzyme immunoassay (EIA), is controversial, especially in patients who test positive by NAAT but negative by EIA. In this systematic review, we compared the clinical outcomes of NAAT+/EIA− versus NAAT+/EIA+ patients and found that the two groups have similar risk of mortality and CDI-related complications. However, NAAT+/EIA− patients had significantly lower rates of recurrence and severe CDI than NAAT+/EIA+ patients, and most NAAT+/EIA− patients received CDI therapy. Toxin testing can help to predict the likelihood of CDI recurrence or severe infection, but the toxin result should not be a determining factor in the administration of CDI therapy. The decision on whether to treat NAAT+/EIA− patients should be based on clinical assessment.
Petrogenesis and tectonic settings of the Neoarchean A-type granitoid complex from the Carajás Province, Amazonian craton: constraints from geochemistry, SHRIMP U‒Pb zircon geochronology and Hf–Nd isotopes
Authors: da Silva Fernando Fernandes , de Oliveira Davis Carvalho , Dall'Agnol Roberto , Schneider Santos João Orestes , Galarza Marco Antonio , Guimarães Fabriciana Vieira , de Sousa Luan Alexandre Martins 
Published: December 2024

The Neoarchean granitoids of the Vila Jussara complex are located in the Sapucaia domain in Carajás Province, where they appear as a series of coalescing, sigmoidal-shaped plutons with high-angle foliations (75–85°) that follow a regional east–west trend. These plutons are mainly formed of seriated biotite–hornblende monzogranite, although subordinate varieties include biotite–hornblende tonalite, biotite granite and hornblende–biotite granite. The granitoids are distinguished by their Fe* index [FeO
t
/(FeO
t
/MgO) ratio]. The biotite–hornblende monzogranites present moderate to high values of this ratio and can be characterized as oxidized and reduced ferroan A-type granites. The biotite granites and hornblende–biotite granites are porphyritic granitoids and are transitional between oxidized granites and slightly magnesian granites. By contrast, the biotite–hornblende tonalites have lower and restricted Fe* indices and magnesian characteristics. Sensitive high-resolution ion microprobe U–Pb dating gives ages of 2743 ± 11 Ma for the oxidized biotite–hornblende monzogranites, 2745 ± 20 Ma for the reduced biotite–hornblende monzogranites, 2742 ± 14 Ma for the hornblende–biotite granites and 2766 ± 9.6 Ma for the biotite–hornblende tonalites. The Nd and Hf isotopic data suggest that the magmas of the Vila Jussara suite present a slight crustal contribution with or without contamination and were derived from rocks of Meso- to Paleoarchean age (2.82 <
T
DM
< 3.45 Ga); the

ε

Nd
(
t
) values are mostly between −3.62 and +1.55 and the

ε

Hf
(
t
) values are between −4.77 and +1.78. The petrogenetic model that was used to determine the primary magmas of this suite suggests that the source rocks were geochemically similar to Mesoarchean granulites from the Canaã dos Carajás domain. The emplacement of Neoarchean granites occurred by multiple injections of magma, generating extensive hybridization under a transpressional/transtensional tectonic regime dominated by pure shear and resulting in a syntectonic post-collisional setting for these rocks.
Scientists as “Specialist Audience” for Art that Addresses Climate Change: Weather Engines at Onassis, Athens, 2022
Authors: Jones Nathan , Dragona Daphne 
Published: December 2024

Abstract
This paper explores the proposition that experiencing art can contribute to scientific discourse on climate issues, especially at the convergence of physical and social sciences. Drawing from an experiment conducted during the Weather Engines exhibition in Athens (2022), it highlights how specialist audiences, notably scientists, engage with contemporary art in their area of specialty, treating the artworks as “research environments” or “discursive spaces” where they can combine their thinking with other scholars. The study prompted scientists to discover novel insights within artworks and propose innovative interpretations of the work. A distinctive metaphorical structure played a crucial role in shaping scientists’ perceptions, fostering fresh perspectives and uncovering layers of meaning that “general audiences” would not perceive. The authors show how insights from this experiment could inform collaborative initiatives to enhance scientists’ ability to tap into the value of contemporary art, particularly regarding climate issues.
The legacy of Rogier van der Weyden: A pair of altarpiece shutters by the workshop of the Master of the View of St Gudula (c. 1480-1500)
Authors: Dimov Alexandre , Martens Didier 
Published: December 2024

This article aims to illustrate the legacy of Rogier van der Weyden (1399/1400-1464) in Brussels through two formerly undocumented altarpiece shutters from the last quarter of the fifteenth century that were auctioned in 2020. An Annunciation is depicted on the reverse of the panels, while the observe shows four scenes of the Passion: the Flagellation of Christ, the Crowning with thorns, the Resurrection of Christ, and the Christ appearing to his mother.
The central ‘caisse’ of this domestic retable, which was probably a carved group, is missing. The paintings can be ascribed to an artist working in Brussels, in the workshop of the Master of the View of St Gudula. A similar Passion cycle, that has been recorded on the Paris art market in 1924, can be attributed to the same workshop. In the present altarpiece shutters, the relationship between the Annunciation and Rogier’s oeuvre is particularly straightforward, as the figure of the angel Gabriel appears in a similar form in a painting by one of the master’s pupils. In addition, following a motif introduced by Rogier, the sceptre of Gabriel is connected with ‘tenons’ as if it was a real sculpture. Obvious similarities also appear when comparing the Flagellation and the Crowning with thorns with two drawings by an artist from Rogier’s closest circle. Also, the composition of the Flagellation can be found in the central panel from the Prado’s Triptych of the Redemption, a work that clearly relies on Rogierian models.
The works that Max Friedländer attributed to the Master of the View of St Gudula in 1926 and 1939 are characterized by differences in quality of execution and style, what scholars led to assume that the artist must have been surrounded by a workshop of several collaborators. Following the authors, one of them, the same who was responsible for two panels from a cycle of Saint Catherine, can now be convincingly assigned to the present altarpiece shutters.
From Transregional to Global Space
Authors: Pal Bidisha , Rahman Md. Mojibur 
Published: December 2024

Abstract
The study analyzes two Bengali Dalit autobiographies in both original and translated versions. One is Itibritte Chandal Jiban (2012) by Manoranjan Byapari (trans. Interrogating My Chandal Life: An Autobiography of a Dalit in 2018), and the other is Amar Bhubane Ami Benche Thaki (2013) by Manohar Mouli Biswas (trans. Surviving in My World: Growing Up Dalit in Bengal in 2015). The present research brings forward some standpoints. First, the translation of Dalit autobiographies creates transnational solidarity. Second, the translators play the role of gatekeepers to show that translation sustains the literary and cultural essence ingrained within the texts and initiates and engages dialogic discussions among the audience and readers on the global platform. Third, the translation of Dalit autobiographies arrests the attention of those global readers who barely nurture any idea on caste, class, and casteist politics and deep-rooted issues like untouchability in India and constructs a distinct literary geography.
The Hungry Generation and the Cold War University
Authors: Moody Alys 
Published: December 2024

Abstract
In 1967, the Beat “mimeo mag” Salted Feathers published a special issue dedicated to the Hungry Generation, a group of young Bengali poets who were then receiving some attention in US avant-garde poetry circles. This article shows that this special issue can productively be read as a product of changes in the research university in the context of the Cold War, as the university increasingly became a site for cross-cultural exchange. While this academic context found itself at odds with the claims to anti-academic authenticity being made by and on behalf of the Indian poets, this article argues that scholarly forms were paradoxically mobilized in order to preserve the poets’ claims to authenticity. It concludes by suggesting that the Salted Feathers special issue on the Hungry Generation offers new insights into how the university became a site for the emergence of world literature.
Does top-down administrative regulation promote urban safety performance? A quasi-natural experiment with evidence of listed special supervision in China
Authors: Liu Zezhao , Wei Shu 
Published: December 2024

Despite the ample literature on safety regulation with an administrative angle, research about how the vertical intervention of central government shapes local governance is still limited. This study sets out to address this gap in a city-based quantitative approach. Specifically, we select the policy of listed special supervision, taken by the Safety Commission of China's State Council, to investigate whether and how the central top-down policy intervention affects the urban government's regulatory performance on a local basis in China. Using panel data from 52 cities from 2010 to 2021, we take listed special supervision implementation as a quasi-natural experiment and examine its policy effects on reducing the urban mortality rate of major accidents. We find that listed special supervision positively affects city regulatory performance, and this promoting effect is significantly attenuated by the interference of corruption. Moreover, listed special supervision’s positive effect is stronger in provincial capital cities (higher hierarchy) than non-capital cities (lower hierarchy). The diverse impacts of listed special supervision also suggest that the Chinese urban power structure and layer-by-layer pressure might compromise the effects of superior's regulations. Empirically, with the panel data for city-level government we found robust evidence supporting our theoretical hypotheses and verifying the policy mechanism in an authoritarian context. Future research is necessary to clarify the heterogeneity effects of listed special supervision by collecting more information on city characteristics and safety policies. Points for practitioners This research reveals the influences of top-down inspectorate supervision on local compliance with a safety regulatory mandate among the hierarchy of city governments. The findings suggest that the maneuvers of city governments in a hierarchical urban system and the inhibitory effect of local corruption in implementing superior's policies should be taken seriously by practitioners when designing regulations to enhance urban safety governance.
Composting and food waste on google news: Connections to nutrition and health
Authors: Basch Emerson D. , Samuel Lalitha 
Published: December 2024

Background Composting is a practical solution to the burgeoning global problem of food waste, which is a significant contributor to landfills and associated environmental effects. Dissemination of accurate information regarding the microbial-driven composting process is critical to positive outcomes. Aim To describe the content of news articles addressing composting. Methods A search was conducted on Google News using keywords, “composting” and the first 100 English-language articles were analyzed for content. The 12 content categories were derived from a United States Department of Agriculture information guide on composting. Details regarding the source of the news article were included. Descriptive statistics were calculated, and chi-square tests of independence were conducted. Results Only 17% of the sample were professional sources. Among the 12 content categories, environmental benefits of composting had maximum coverage (68%). Inclusion of the topics of environmental benefits ( p = 0.03) and role of composting in landfill reduction ( p = 0.03) was significantly associated with the article being a professional source. Conclusions The Internet presents opportunities for food and environmental experts to disseminate accurate information regarding composting, and partner at various levels into recycle food and organic waste to value-added products.
A retrospective investigation of varied dose of heparin for cardiopulmonary bypass for repair of cardiac myxomas
Authors: Wei Dengzhi , Wang Xiaoxu , Tian Haiying , Li Xu , Xiang Daokang , Shu Yizhu 
Published: December 2024

Introduction There is no consensus on the dose of heparin to be used intraoperatively in cardiac myxomas, so the goal of this study was to look into the differences in the clinical effects on the perioperative period of patients with cardiac myxomas when different doses of heparin were used intraoperatively. Methods and Analysis 70 patients who had cardiac myxomas excision via cardiopulmonary bypass between January 2024 and July 2024. The 70 patients were separated into two groups based on the heparin dose administered prior to cardiopulmonary bypass heparinization. 42 patients in group A had a dose of ≤400 U/kg, while 28 patients in group B received a dose of >400 U/kg. Result PT, INR, and APTT were significantly prolonged in patients with cardiac myxomas in group A in the postoperative period 24 h after surgery, which was statistically significant ( P < .05) compared with that in group B. Intraoperative heparin dose appeared to influence changes in coagulation at 24 h postoperatively, but was mainly dominated by APTT. Also, heparinized doses showed a weak positive correlation with 24-h postoperative drainage volume. In addition, the dimension of the cardiac myxomas appeared to have some correlation with the patient’s preoperative APTT and age. Conclusion When patients with cardiac myxomas were heparinized intraoperatively with varying doses of heparin, the enhancement of coagulation in the 24 h after surgery was more pronounced in the group given higher doses of heparin, and endogenous coagulation pathways were activated much more than exogenous coagulation pathways in the 24 h after surgery.