bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biônica aplicada à modelagem voltada a sustentabilidade: contribuições do modelo Modthink
Authors: Bilmaia Emidio Lucimar de Fátima , Ribeiro Bertolino Karoline Cristyna 
Published: June 2020

O presente estudo apresenta o resultado da aplicação das fases metodológicas do modelo MODThink de Emídio (2018), no contexto de um projeto acadêmico da primeira série do curso de Design de Moda da Universidade Estadual de Londrina. Demonstra como, por intermédio da aplicação da ferramenta de criatividade biônica, foi possível incluir o conceito do projeto na modelagem do produto, além de contribuir para aspectos de produção voltados à sustentabilidade. Contribui-se para estabelecer uma linguagem comum entre a área de design e de modelagem,a partir do uso de ferramentas de design e técnicas de criatividade como recursos cognitivos para potencializar as estruturas mentais dos alunos na construção do conhecimento em modelagem.
The prediction of swim start performance based on squat jump force-time characteristics
Authors: Thng Shiqi , Pearson Simon , Rathbone Evelyne , Keogh Justin W.L. 
Published: June 2020

Background
Depending on the stroke and distances of the events, swim starts have been estimated to account for 0.8% to 26.1% of the overall race time, with the latter representing the percentage in a 50 m sprint front crawl event (Cossor & Mason, 2001). However, it is still somewhat unclear what are the key physiological characteristics underpinning swim start performance. The primary aim of this study was to develop a multiple regression model to determine key lower body force-time predictors using the squat jump for swim start performance as assessed by time to 5 m and 15 m in national and international level swimmers. A secondary aim was to determine if any differences exist between males and females in jump performance predictors for swim start performance.

Methods
A total of 38 males (age 21 ± 3.1 years, height 1.83 ± 0.08 m, body mass 76.7 ± 10.2 kg) and 34 females (age 20.1 ± 3.2 years, height 1.73 ± 0.06 m, body mass 64.8 ± 8.4 kg) who had competed at either an elite (n = 31) or national level (n = 41) participated in this study. All tests were performed on the same day, with participants performing three bodyweight squat jumps on a force platform, followed by three swim starts using their main swimming stroke. Swim start performance was quantified via time to 5 m and 15 m using an instrumented starting block.

Results
Stepwise multiple linear regression with quadratic fitting identified concentric impulse and concentric impulse2 as statistically significant predictors for time to 5 m (R2 = 0.659) in males. With time to 15 m, concentric impulse, age and concentric impulse2 were statistically significant predictors for males (R2 = 0.807). A minimum concentric impulse of 200–230 N.s appears required for faster times to 5 m and 15 m, with any additional impulse production not being associated with a reduction in swim start times for most male swimmers. Concentric impulse, Reactive strength index modified and concentric mean power were identified as statistically significant predictors for female swimmers to time to 5 m (R2 = 0.689). Variables that were statistically significant predictors of time to 15 m in females were concentric impulse, body mass, concentric rate of power development and Reactive strength index modified (R2 = 0.841).

Discussion
The results of this study highlight the importance of lower body power and strength for swim start performance, although being able to produce greater than 200 or 230 N.s concentric impulse in squat jump did not necessarily increase swim start performance over 5 m and 15 m, respectively. Swimmers who can already generate greater levels of concentric impulse may benefit more from improving their rate of force development and/or technical aspects of the swim start performance. The sex-related differences in key force-time predictors suggest that male and female swimmers may require individualised strength and conditioning programs and regular monitoring of performance.
Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma
Authors: Fan Demin , Liu Qiang , Wu Fei , Liu Na , Qu Hongyi , Yuan Yijiao , Li Yong , Gao Huayu , Ge Juntao , Xu Yue , Wang Hao , Liu Qingyong , Zhao Zuohui 
Published: June 2020

Background
Renal cell carcinoma (RCC) is a fatal disease, in which the PI3K/AKT/mTOR signaling pathway serves an important role in the tumorigenesis. Previous studies have reported the prognostic significance of PI3K/AKT/mTOR signaling pathway members in RCC; however, there is insufficient evidence to date to confirm this. Thus, the present study aimed to systematically investigate the prognostic roles of multiple PI3K/AKT/mTOR signaling proteins in clear cell RCC (ccRCC) using online large-scale databases.

Methods
The mRNA expression profiles of PI3K/AKT/mTOR signaling pathway proteins PTEN, PIK3CA, PIK3CB, PIK3CD, PIK3CG, AKT1, AKT2, AKT3 and mTOR were investigated using the Gene Expression Profiling Interactive Analysis (GEPIA) and Oncomine databases, and the protein expression levels of PI3K, AKT and mTOR were detected using western blotting (WB) analysis. In addition, the correlation between mRNA or protein expression levels and the prognostic significance was analyzed using the Kaplan-Meier (K-M) plotter (n = 530), the Human Protein Atlas (HPA; n = 528) and The Cancer Protein Atlas (TCPA; n = 445) databases.

Results
The GEPIA revealed that the mRNA expression of major PI3K/AKT/mTOR pathway members, including PTEN, PIK3CA, PIK3CB, AKT1, AKT2 and AKT3, were negatively correlated with ccRCC stages (P < 0.05), though most of their mRNA and protein expression levels were notsignificantly different between ccRCC and normal tissues using GEPIA, Oncomine and WB analyses (P < 0.05). Meanwhile, using the K-M plotter and HPA prognostic analysis, it was found that the mRNA expression levels of the majority of the PI3K/AKT/mTOR signaling pathway members, including PTEN, PIK3CA, PIK3CB, PIK3CG, AKT3 and mTOR were positively correlated with overall survival (OS), whereas PIK3CD mRNA expression was negatively correlated with OS (P < 0.05). Furthermore, TCPA prognostic analysis observed that several of the key molecules of the PI3K/AKT/mTOR signaling pathway [PTEN, p-AKT (S473) and p-mTOR (S2448)] were also positively correlated with OS in patients with ccRCC (P < 0.05). In conclusion, the present study suggested that several members of the PI3K/AKT/mTOR signaling pathway, especially PTEN, may be favorable prognostic factors in ccRCC, which indicated that the PI3K/AKT/mTOR signaling pathway may be implicated in ccRCC initiation and progression.
PERFIL QUE DEFINE UM PROFESSOR EXEMPLAR: PERCEPÇÃO DE ALUNOS DA PÓS-GRADUAÇÃO STRICTO SENSU EM CIÊNCIAS CONTÁBEIS NO BRASIL
Authors: Amaral Leonardo Barbosa , Gonçalves de Resende Freitas Adriana , Taboada Pinheiro Laura Edith 
Published: June 2020

<div id="icpbravoaccess_loaded">O objetivo desta pesquisa é identificar as características que os alunos da pós-graduação <em>stricto sensu</em> em Ciências Contábeis, consideram pertinentes ao professor exemplar. O levantamento dos dados foi operacionalizado por meio de um questionário elaborado e divulgado de forma on-line. Utilizou-se um conjunto de fatores que delineiam o professor exemplar. São eles: (i) conhecimento, planejamento e didática; (ii) capacidade tecnológica; (iii) relacionamento com os discentes; (iv) atributos pessoais; (v) capacidade de motivação e seu (vi) nível de exigência. A amostra é composta por 132 discentes matriculados em 13 universidades e faculdades brasileiras. Para a análise dos dados, empregou-se a estatística descritiva e a técnica de análise fatorial. Os resultados da pesquisa indicam que o perfil de um professor exemplar pode ser definido como aquele profissional docente que exibe características ligadas ao relacionamento com os alunos, ao planejamento das aulas, ao conhecimento do assunto que está ensinando e à sua didática. </div><div id="icpbravoaccess_loaded"> </div><div id="icpbravoaccess_loaded"> </div><div id="icpbravoaccess_loaded"> </div><div id="icpbravoaccess_loaded"> </div><div id="icpbravoaccess_loaded"> </div>
Delay in diagnosis of epithelial ovarian cancer
Authors: Wikborn C. , Pettersson F. , Moberg P.J. 
Published: July 2002

AbstractObjectives: To investigate and analyze the process from first recognition of symptom(s) to final diagnosis at operation in patients with ovarian epithelial cancer. Method: The medical records of 160 women with ovarian cancer were studied and traced back to the doctor first consulted, in order to obtain information on patient‐ and doctor‐related delay. Results: Symptom duration was 12 weeks in patients with serous tumors and 7 weeks in patients with other histopathological classes; 56% were diagnosed within 4 weeks. Women in stages I and II were diagnosed faster than those in stages III and IV; 4% were diagnosed within 3 days because of an emergency operation; 30% were not diagnosed within 8 weeks. Conclusion: Diagnosis of ovarian cancer is difficult due to the vagueness of the symptoms which mislead both patients and doctors. Methods to enable earlier diagnosis must be sought.
Functional roles of abdominal and back muscles during isometric axial rotation of the trunk
Authors: Ng Joseph K.‐F. , Parnianpour Mohamad , Richardson Carolyn A. , Kippers Vaughan 
Published: July 2002

AbstractElectromyographic (EMG) studies have shown that a large number of trunk muscles are recruited during axial rotation. The functional roles of these trunk muscles in axial rotation are multiple and have not been well investigated. In addition, there is no information on the coupling torque at different exertion levels during axial rotation. The aim of the study was to investigate the functional roles of rectus abdominis, external oblique, internal oblique, latissimus dorsi, iliocostalis lumborum and multifidus during isometric right and left axial rotation at 100%, 70%, 50% and 30% maximum voluntary contractions (MVC) in a standing position. The coupling torques in sagittal and coronal planes were measured during axial rotation to examine the coupling nature of torque at different levels of exertions. Results showed that the coupled sagittal torque switches from nil to flexion at maximum exertion of axial rotation. Generally, higher EMG activities were shown at higher exertion levels for all the trunk muscles. Significant differences in activity between the right and left axial rotation exertions were demonstrated in external oblique, internal oblique, latissimus dorsi and iliocostalis lumborum while no difference was shown in rectus abdominis and multifidus. These results demonstrated the different functional roles of trunk muscles during axial rotation. This is important considering that the abdominal and back muscles not only produce torque but also maintain the spinal posture and stability during axial rotation exertions. The changing coupling torque direction in the sagittal plane when submaximal to maximal exertions were compared may indicate the complex nature of the kinetic coupling of trunk muscles. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
CRITICAL ISSUES IN THE CARE OF PREGNANT WOMEN WITH EATING DISORDERS AND THE IMPACT ON THEIR CHILDREN
Authors: Little Liza , Lowkes Emily 
Published: July 2002

ABSTRACTPregnancy and eating disorders is a subject that has received relatively little attention in the literature. Nevertheless, serious complications have been found in both the mother and the baby during both pregnancy and post partum period. This article alerts practitioners to the physical and psychological risks that imperil pregnant women with histories of recent eating disorders, describes the experiences of three women with eating disorders during pregnancy whose children developed eating difficulties, and suggests some guidelines for the screening and care of women with eating disorders and their babies.
Trusting Women: Essential to Midwifery
Authors: Thorstensen Katrina Alef 
Published: July 2002

ABSTRACTNonintervention in normal processes and promoting self‐determination are both important aspects of midwifery philosophy and care; midwives are sometimes faced with situations in which these actually or potentially conflict. An example of this is epidural anesthesia, when the normal process of labor and birth may be affected by the woman's choices. This article focuses on an approach to this conflict that is essential to midwifery but often overlooked: the importance of trusting women to know what is best for themselves. The concept of trust in midwifery care is explored in depth, as a context from which to provide care, promote normal processes, ensure informed decision‐making, empower women no matter what choices they make, and, when the woman's choice and midwife's philosophy differ, as a bridge from which to provide effective midwifery care.
Newborn Hearing Screening Update For Midwifery Practice
Authors: Narrigan Deborah 
Published: July 2002

ABSTRACTNeonatal identification of congenital hearing impairment allows interventions during the first 3 years, the critical period for language and speech development. Two recently developed biophysical testing methods offer simple, accurate, and relatively inexpensive means to identify the one to three in 1,000 healthy newborns with hearing loss. Universal screening for auditory system integrity is advocated, because almost half of all newborns with hearing impairment have no risk factors associated with this impairment. Critics of universal screening cite the high rate of false positive tests (up to 7%), which increases program costs from follow‐up and re‐testing large numbers of infants to ensure identifying the few affected infants. As of early 2000, 24 states had introduced some type of auditory screening program, and the U.S. Congress had passed legislation with appropriations mandating state‐based auditory screening for all newborns. Midwives practicing in states already mandating biophysical screening need to comply with their local requirements; those in other states may voluntarily incorporate new auditory test methods into practice.
Health Care–Seeking Practices of Pregnant Women and the Role of the Midwife in Cape Town, South Africa
Authors: Abrahams Naeemah , Jewkes Rachel , Mvo Zodumo 
Published: July 2002

ABSTRACTThe objective of this study was to investigate the health‐seeking practices of pregnant women in a periurban area in Cape Town, South Africa. This qualitative study was based on 103 minimally structured in‐depth interviews of 32 pregnant women. Most women were interviewed on several occasions, and a group discussion was held with women. The interviews were taped, transcribed, analyzed ethnographically, and, if necessary, translated into English. Antenatal care attendance was influenced by a number of factors, including women's knowledge of the role of antenatal care, perceived health needs, booking systems, nurse‐patient relationships, economics, child care, and transport. The expected benefits were weighed against the anticipated costs before decisions about seeking care were made. The findings highlight the importance of women's perceptions of quality of care in influencing their health seeking practices. The study suggests that considerably more attention needs to be given to this aspect of maternity services.
Current Best Evidence: A Review of the Literature On Umbilical Cord Clamping
Authors: Mercer Judith S. 
Published: July 2002

ABSTRACTImmediate clamping of the umbilical cord can reduce the red blood cells an infant receives at birth by more than 50%, resulting in potential short‐term and long‐term neonatal problems. Cord clamping studies from 1980 to 2001 were reviewed. Five hundred thirty‐one term infants in the nine identified randomized and nonrandomized studies experienced late clamping, ranging from 3 minutes to cessation of pulsations, without symptoms of polycythemia or significant hyperbilirubinemia. Higher red blood cell flow to vital organs in the first week was noted, and term infants had less anemia at 2 months and increased duration of early breastfeeding. In seven randomized trials of preterm infants, benefits associated with delayed clamping in these infants included higher hematocrit and hemoglobin levels, blood pressure, and blood volume, with better cardiopulmonary adaptation and fewer days of oxygen and ventilation and fewer transfusions needed. For both term and preterm infants, few, if any, risks were associated with delayed cord clamping. Longitudinal studies of infants with immediate and delayed cord clamping are needed.
Kistimonas
Authors: Glaeser Stefanie P. , Kämpfer Peter 
Published: June 2020

Abstract

Kis.ti.mo'nas. L. fem. n.
monas
, a unit, monad; N.L. fem. n.
Kistimonas
, a monad from KIST, the Korea Institute of Science and Technology.

Proteobacteria / Gammaproteobacteria / Oceanospirillales / Endozoicomonadaceae / Kistimonas

The genus
Kistimonas
accommodates bacteria with motile, rod‐shaped cells. Non‐spore‐forming. Gram‐strain‐negative. Aerobic or facultatively anaerobic. Catalase‐ and oxidase‐variable.

All
Kistimonas
species are able to grow between 15 and 30°C. Some species are able to grow at 10, 37, and even 45°C. All species grow at a pH range of pH 6.0–10.0 and in the presence of 1–4% NaCl. No growth without NaCl. Growth up to 9% NaCl was reported for some species.

Genome sequence data are not available yet. Predominant cellular fatty acids of all
Kistimonas
species are a summed feature composed of C
16 : 1
ω7
c
and/or iso‐C
15:0
2‐OH and C
16 : 0
. Major polar lipids are phosphatidylserine, phosphatidylglycerol, phosphoethanolamine, and diphosphatidylglycerol. The major respiratory quinone is ubiquinone Q‐9. The genus is a member of the class
Gammaproteobacteria
, order
Oceanospirillales
, forming a monophyletic clade within the family
Endozoicomonadaceae
. Known habitats are marine invertebrates including the skin of the sea star
Asterias amurensis
, the gastrointestinal tract of the sandworm
Alitta succinea
, and dead ark clam
Scapharca broughtonii
.

DNA G + C content (mol%)
: 47.3–52.5 (HPLC,
T
m
).

Type species
:
Kistimonas asteriae
Choi et al. 2010
VP
.
The dosimetric impact of stabilizing spinal implants in radiotherapy treatment planning with protons and photons: standard titanium alloy vs. radiolucent carbon‐fiber‐reinforced PEEK systems
Authors: Müller Birgit S. , Ryang Yu‐Mi , Oechsner Markus , Düsberg Mathias , Meyer Bernhard , Combs Stephanie E. , Wilkens Jan J. 
Published: June 2020

AbstractBackgroundThroughout the last years, carbon‐fibre‐reinforced PEEK (CFP) pedicle screw systems were introduced to replace standard titanium alloy (Ti) implants for spinal instrumentation, promising improved radiotherapy (RT) treatment planning accuracy. We compared the dosimetric impact of both implants for intensity modulated proton (IMPT) and volumetric arc photon therapy (VMAT), with the focus on uncertainties in Hounsfield unit assignment of titanium alloy.MethodsRetrospective planning was performed on CT data of five patients with Ti and five with CFP implants. Carbon‐fibre‐reinforced PEEK systems comprised radiolucent pedicle screws with thin titanium‐coated regions and titanium tulips. For each patient, one IMPT and one VMAT plan were generated with a nominal relative stopping power (SP) (IMPT) and electron density (ρ) (VMAT) and recalculated onto the identical CT with increased and decreased SP or ρ by ±6% for the titanium components.ResultsRecalculated VMAT dose distributions hardly deviated from the nominal plans for both screw types. IMPT plans resulted in more heterogeneous target coverage, measured by the standard deviation σ inside the target, which increased on average by 7.6 ± 2.3% (Ti) vs 3.4 ± 1.2% (CFP). Larger SPs lead to lower target minimum doses, lower SPs to higher dose maxima, with a more pronounced effect for Ti screws.ConclusionsWhile VMAT plans showed no relevant difference in dosimetric quality between both screw types, IMPT plans demonstrated the benefit of CFP screws through a smaller dosimetric impact of CT‐value uncertainties compared to Ti. Reducing metal components in implants will therefore improve dose calculation accuracy and lower the risk for tumor underdosage.
Risk of incident autoimmune diseases in patients with thymectomy
Authors: Lin Tzu‐Min , Chang Yu‐Sheng , Hou Tsung‐Yun , Hsu Hui‐Ching , Lin Sheng‐Hung , Chen Wei‐Sheng , Kuo Pei‐i , Lin Yi‐Chun , Chen Jin‐Hua , Chang Chi‐Ching 
Published: June 2020

AbstractObjectivesThe data concerning the association between Tx and ADs remain unclear and are scarce. This study was undertaken to investigate whether people with Tx are more likely to develop ADs, compared to those without Tx.MethodsIndividuals who received Tx between 2002 and 2015 were identified and matched on age and sex with individuals without Tx. We performed multivariate and stratified analysis using the Kaplan–Meier method and Cox proportional hazards models in order to estimate the association between Tx and the risk of developing ADs.ResultsA total of 2550 thymectomized (Txd) patients and 24,664.941 non‐Txd comparison subjects were selected from NHIRD. Tx‐MG (myasthenia gravis) as compared with general population (nonTx‐nonMG), adjusted hazard ratio (aHR) were higher for incident Addison disease (aHR = 10.40, 95% CI 1.01–107), autoimmune hemolytic anemia (aHR = 21.54, 95% CI 2.06–14.8), Hashmoto thyroiditis (aHR = 5.52, 95% CI 1.34–34.7), ankylosing spondylitis (aHR = 2.73, 95% CI 1.09–6.84), rheumatoid arthritis (aHR = 5.25, 95% CI 1.79–15.47), primary Sjogren syndrome (pSS) (aHR = 3.77, 95% CI 1.30–11.0), and systemic lupus erythemtoasus (aHR = 10.40). Tx‐nonMG as compared with general population, aHR were higher for incident autoimmune hemolytic anemia (aHR = 25.50), Hashmoto thyroiditis (aHR = 6.75) and systemic lupus erythematosus (SLE) (aHR = 13.38). NonTx‐MG as compared with general population, aHR were higher for incident Hashmoto thyroiditis (aHR = 6.57), pSS (aHR = 4.50), SLE (aHR = 17.29), and systemic vasculitis (aHR = 25.86).InterpretationIn conclusion, based on a retrospective cohort study throughout Taiwan, patients with Tx have a higher risk of new onset ADs than patients without Tx.
Highly dispersed and active Pd nanoparticles over titania support through engineering oxygen vacancies and their anchoring effect
Authors: Wang Xuyu , Zou Xuelin , Rui Zebao , Wang Yongqing , Ji Hongbing 
Published: May 2020

AbstractRational synthesis of highly dispersed and active metal nanoparticles (NP) for application in catalysis has been a hot but challenging research topic. Herein, we report a facile strategy for dispersing and stabilizing noble metal NP in a reducible metal oxide support (e.g., TiO2) through engineering oxygen vacancies and their anchoring effect. The pre‐reduction of TiO2 support produces oxygen vacancies, and Pd NP prefer to occupy these vacancies with a strong meal‐support interaction and near metallic state. A near monatomic Pd NP distribution over anatase TiO2 support is obtained with this strategy. Significant activity enhancement is demonstrated in both oxygen activation and formaldehyde oxidation reactions by this catalyst design method. H2, NaBH4 and HCHO are suitable reducing agent for TiO2, the pre‐reduction catalysts by H2, NaBH4 and HCHO shows highly activity for formaldehyde oxidation. Such a work demonstrates support pre‐reduction strategy is a facile way to prepare powerful supported noble metal catalysts.