bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children with Early Sexual Maturation Exhibit Changes in Dairy and Soybean Consumption: A 6-Year Nationwide Study
Authors: Nguyen Ngan Thi Kim , Fan Hsien-Yu , Huang Shih-Yi , Hou Jia-Woei , Yang Chen , Chen Yang Ching 
Published: July 2020

Abstract
BackgroundEarly sexual maturation (ESM) is associated with behavioral disorders in adolescence and hormone-related cancers in adulthood. Dietary pattern (DP) has been noticed in association with ESM. However, to our knowledge, no study has shown that association between DP derived from reduced-rank regression (RRR) and ESM, and whether ESM influences tracking dietary habit in children. This study was therefore to examine the prospective association between childhood dietary pattern (DP) and ESM, and whether ESM influenced children’s dietary habit during 6 years of pubertal growth.MethodsThis longitudinal study, using the Taiwan Children Health Study cohort, included 2593 peripubertal children aged 11.1 ± 0.3 years in 2011. DPs were derived by factor analysis (FA) and reduced-rank regression (RRR) methods from food frequency questionnaires. ESM was assessed in 2012 at age 12.1 ± 0.3 years. Multivariate logistic regression was used to examine the association between DP scores and ESM (n = 2593). The change in DP scores between 2011 and 2017 was obtained by comparing baseline DP scores with those participants who completed the final assessment (n = 1018).ResultsAt baseline, 3 DPs (dairy–soybean, traditional, and vegetarian diet) were identified using FA. Children with FA-derived dairy–soybean diet had a significantly higher risk of ESM (females: odds ratio [OR] = 1.58, 95% confidence interval [CI]: 1.07, 2.32; P = 0.02; males: OR = 1.42, 95% CI: 1.08, 1.86; P = 0.01) after adjusting for parent education, family income, fat percentage, total energy intake, and screen time. RRR-derived DPs yielded similar associations. Children who experienced ESM exhibited a significantly higher decrease in DP scores of “dairy–soybean diet” than did children without ESM over a 6-year period. Children with ESM were prone to resume “traditional diet” after completing pubertal growth.ConclusionsAdherence to “dairy–soybean diet” in childhood were associated with ESM; therefore, children undergoing pubertal growth should be advised on appropriate levels of dairy and soybean consumption, even after completion of pubertal growth.Data Share StatementData described in the manuscript, code book, and analytic code will be made available upon request pending either before or after publication for checking through contact with the authors by emails.
Anxiety and Emotional-Behavioral Problems of Adolescents in China: Evidence for A Serial Mediation Model of Alexithymia and Dependency
Authors: Liang Lijuan , Zhu Wei , Yang Juan , Wang Fei 
Published: July 2020

Abstract
Background: High prevalence of emotional and behavioral problems among Chinese adolescence has been reported. This study seeks to investigate the mediating effect of alexithymia and dependency on anxiety and emotional-behavioral problems among adolescents.The study focused a serial mediation model of alexithymia and dependency adolescents from Haikou, China.Methods: The study population included 519 adolescents. The assessments included the completion of standardized scales such as the Multidimensional Anxiety Scale (MASC), the Toronto Alexithymia Scale (TAS-20), the Depressive Experiences Questionnaire (DEQ), the Strengths and Difficulties Questionnaire (SDQ). Independent-sample t-tests, bivariate correlation, and serial mediation analyses were performed using SPSS23.0.Results: Bivariate analyses revealed that anxiety, emotional-behavioral problem, alexithymia, and dependency were positively correlated. Alexithymia and dependency play a significant role in mediating the effect of multidimensional anxiety on emotional-behavioral problems. The effects of the three mediating paths were 69.86%,17.81% and 12.33% for paths 1, 2 and 3 respectively.Conclusions: Anxiety and emotional-behavioral problems mediate the relationship between alexithymia and dependency.
Premedication with parecoxib sodium for reduction of propofol injection pain: a randomized placebo-controlled trial
Authors: gu xiaoxia , Huang Weiming , Wang Jingjing , Lu Yue , Chen Jinxian , Zhang Liangqing 
Published: July 2020

Abstract
Background

To compare the effect of premedication with two different doses of parecoxib sodium to prevent pain at propofol intravenous injection.

Methods

We conducted a double-blind randomized controlled trial in which patients scheduled for induction of general anesthesia with intravenous propofol received either a placebo, 20 mg or 40 mg of parecoxib sodium (P20 and P40, respectively) 30min prior to induction. 2mg/kg of propofol was injected at a rate of 600 ml/hr. After 1/4 of the full dose had been injected, the syringe pump was paused, and patients were asked to rate pain at the injection site using a verbal numerical rating score (VNRS) from 0 to 10.

Results

Three hundred and twenty-four patients were included. Pain intensity was lower in both P20 and P40 groups (median VNRS [interquartile range] = 2 [0–3] and 4 [3–6], respectively) than in the placebo group (8 [7–10]; P < 0.001)*. The rate of pain was lower in the P40 group (62.9%) than in both the P20 and the placebo group

(87.0 and 98.2%, respectively; P < 0.001)*. The respective rates of mild (VNRS 1–3), moderate (VNRS 4–6) and severe pain (VNRS 7–10) were 46.1, 22.3 and 0% in the P40 group, 29.7, 55.4 and 8.5% in the P20 group, and 0, 24.2 and 77.8% in the placebo group (P < 0.001* for between group comparisons). Tolerance was similar in the 3 groups.

Conclusions

A premedication with parecoxib sodium can dose-dependently reduce pain at propofol intravenous injection. To avoid this common uncomfortable concern for the patients, this well-tolerated, available and cheap treatment appears as an option to be implemented in the current practice.
Comparison of the predictive value of progesterone-related indicators for pregnancy outcomes of women undergoing the short-acting GnRH agonist long protocol: a retrospective study
Authors: Zhang Yangyang , Xu Yang , Wang Yuqiong , Xue Qing , Shang Jing , Yang Xiuli , Shan Xuemin 
Published: July 2020

Abstract
Background
There are many progesterone (P) elevation-related indicators for predicting pregnancy outcomes, including serum P, P-to-oestradiol ratio (P/E2), P-to-follicle index (PFI), and P-to-mature oocyte index (PMOI); however, due to inconsistencies in study populations and controlled ovarian hyperstimulation (COH) protocols among studies, these indicators are controversial. Moreover, no researchers have included these four commonly used indicators in one study to compare their predictive efficacies. The objective of this study was to compare the predictive value of P-related indicators for pregnancy outcome of women undergoing the short-acting GnRH agonist long protocol.
Methods
A total of 612 infertile women undergoing IVF/ICSI were recruited for this study. Serum samples were obtained on the morning of HCG injection for serum P and E2 measurements. Transvaginal ultrasound was performed to determine the follicle count (≥ 14 mm). The number of mature oocytes was observed in the embryo laboratory after oocyte retrieval.
Results
In cases of P < 2.5 ng/ml, there was no significant difference in the serum P level or P/E2 between the pregnant group and the non-pregnant group. The PFI and PMOI of the pregnant group were significantly lower than those of the non-pregnant group. According to the stratified analysis of the ovarian response, only the PMI and PMOI of the pregnant women in the normal ovarian response group were lower than those of the non-pregnant women. In order to compare the predictive value of the PFI and PMOI in IVF/ICSI outcomes, patients were divided into four groups. The good-quality embryo rate and clinical pregnancy rate were highest in Group A (low PFI and low PMOI) and lowest in Group D (high PFI and high PMOI). In the two groups with discordant PFI and PMOI, namely, Group B (low PFI and high PMOI) and Group C (high PFI and low PMOI), the good-quality embryo rate and clinical pregnancy rate were not significantly different.
Conclusions
PFI and PMOI had equal value in predicting clinical pregnancy outcomes in the normal ovarian response group undergoing the short-acting GnRH agonist long protocol. Each clinical centre can choose one of the indicators according to their actual situation in clinical practice.
Genome Wide Characterization and Comparative Analysis of Simple Sequence Repeats in Cucurbita Genomes
Authors: Zhu Lei , Zhu Hua yu , Li Yan man , Wu Xiang bin , Li Jin tao , Zhang Zhen li , Wang Yan jiao , Hu Jian bin , Yang Sen , Li Yong qiang , Sun Shou ru , Yang Lu Ming 
Published: July 2020

Abstract
Background The Cucurbita genus contains important economic crops in the world, while limited molecular markers have been developed in the past years. Simple sequence repeats (SSR) markers are powerful tools for the study of genetic mapping construction, genetic diversity analysis and genome wide association. The availability of pumpkin genome information has made it possible to analyze SSRs in genome wide across three Cucurbita species. Results In this paper, based on the whole genome sequences, 34,375 SSR loci were found in C. moschata, 30,577 SSR loci were found in C. maxima and 38,104 SSR loci were found in C. pepo. C. pepo has the maximum density of SSRs with an average of 145 SSR/Mb. In general, the frequency in total SSR loci decreased with the increase of the motif length, dinucleotide motifs were the most common motifs in the three species, and for the same repeat types, the SSR frequency decreased sharply with the increase of the repeat number. Most of those SSR loci were suitable for marker development (84.75% in C. moscata, 94.53% in C. maxima and 95.09% in C. pepo). Based on those markers, we compared and analyzed the cross-species SSR markers between C. pepo and other Cucurbitaceae species by silico-PCR. Using these cross-species primers, the high collinear relationships between C. pepo and the other two species were detected, respectively. Furthermore, the application of SSR markers in genetic diversity analysis was tested in C. pepo, the results showed that they were good tools to be used in genetic diversity analysis. Conclusion In this study, the genome wide SSR markers were detected from three Cucurbita species, and some of their applications were proved by comparative genomics and genetic diversity analysis. The large number of genome-wide SSR markers and crossspecies markers would promote the basic and applied studies of Cucurbita species, such as gene mapping, QTLs mapping, comparative genomics and marker-assisted breeding.
Concurrence of talaromycosis and Kaposi sarcoma in a HIV-infected patient: A case report
Authors: Su Feifei , Miao Xingguo , Ye Hui , Yang Shoufeng 
Published: July 2020

Abstract
Background: Concurrence of talaromycosis, an opportunistic infection caused by fungal pathogen Talaromyces marneffei and Kaposi sarcoma, the most common neoplasm in patients infected with human immunodeficiency virus (HIV) has only been rarely reported. Despite poor clinical outcomes, clinical characteristics and management of these concurrent diseases in HIV-infected patients has not been described.Case presentation: A 33-year-old, HIV-positive male patient presented to the Department of Infectious Diseases at Wenzhou Central Hospital with cough, sputum expectoration, hemoptysis, rashes on the feet and violaceous plaques in the oral cavity. Chest computed tomography (CT) showed bilateral nodular, patchy shadows and lymphadenectasis. Skin biopsy and histopathological examination suggested Kaposi sarcoma. Talaromyces marneffei was isolated from blood cultures and supported talaromycosis. The patient presented significant resolution of symptoms following chemotherapy for Kaposi sarcoma and antifungal treatment for talaromycosis.Conclusions: Severe medical conditions such as Kaposi sarcoma and talaromycosis may coexist in HIV-infected patients, posing a high mortality risk. Etiological diagnosis and specifically directed treatment are vital for successful management of HIV-infected patients who develop these comorbid diseases
Intervention strategies with 2D cellular automata for testing SARS-CoV-2 and reopening the economy
Authors: Lugo Igor , Alatriste-Contreras Martha G. 
Published: July 2020

Abstract
During the period of time between a new disease outbreaks and its vaccine is deployed, the health and the economic systems have to find a testing strategy for reopening activities. In particular, asymptomatic individuals, who transmit locally the covid-19 indoors, have to be identified and isolated. We proposed a 2D cellular automaton based on the SI epidemic model for selecting the most desirable testing frequency and identifying the best fitting size of random trails on local urban environments to diagnose SARS-CoV-2 and isolate infected people. We used the complex systems approach to face the challenge of a large-scale test strategy based on urban interventions, starting with first responders and essential workers. We used the case of Mexico to exemplify a credible and intelligent intervention that reduces the virus transmission and detects economic and health costs. Findings suggest that controlling and stopping the virus transmission in a short period of time are possible if the frequency of testing is daily and the percentage of random samples to be tested is at least 90%. This combination of model parameters represents the least expensive intervention compared to others. Therefore, the key for a national testing-isolating strategy is local interventions.
An Efficient Data Imputation Technique for Human Activity Recognition
Authors: Pires Ivan Miguel , Hussain Faisal , Garcia Nuno M. , Zdravevski Eftim 
Published: July 2020

Abstract
The tremendous applications of human activity recognition are surging its span from health monitoring systems to virtual reality applications. Thus, the automatic recognition of daily life activities has become significant for numerous applications. In recent years, many datasets have been proposed to train the machine learning models for efficient monitoring and recognition of human daily living activities. However, the performance of machine learning models in activity recognition is crucially affected when there are incomplete activities in a dataset, i.e., having missing samples in dataset captures. Therefore, in this work, we propose a methodology for extrapolating the missing samples of a dataset to better recognize the human daily living activities. The proposed method efficiently pre-processes the data captures and utilizes the k-Nearest Neighbors (KNN) imputation technique to extrapolate the missing samples in dataset captures. The proposed methodology elegantly extrapolated a similar pattern of activities as they were in the real dataset.
Effect of water on carbonate-silicate liquid immiscibility in the system KAlSi3O8-CaMgSi2O6-NaAlSi2O6-CaMg(CO3)2 at 6 GPa: Implications for diamond-forming melts
Authors: Shatskiy Anton , Arefiev Anton V. , Podborodnikov Ivan V. , Litasov Konstantin D. 
Published: July 2020

AbstractTo clarify the effect of water on carbonate-silicate liquid immiscibility in the diamond stability field, we performed experiments in the system KAlSi3O8-CaMgSi2O6-NaAlSi2O6-CaMg(CO3)2 under nominally dry and hydrous conditions by adding 1.5 wt% H2O at a pressure of 6 GPa and temperatures of 1000 to 1500 °C. Both systems start to melt at 1050–1100 °C. Under anhydrous condition the melting occurs via the following reaction: 6KAlSi3O8 (K-feldspar) + 6CaMg(CO3)2 (dolomite) = 2(Can,Mg1-n)3Al2Si3O12 (garnet) + Al2SiO5 (kyanite) + 11SiO2 (coesite) + 3 K2(Ca1-n, Mgn)2(CO3)3 (carbonatitic melt) + 3CO2 (fluid and/or liquid), whereñ 0.3–0.4. The carbonatitic melt has the following composition 38(K0.92Na0.08)2CO3⋅62Ca0.62Mg0.38CO3. A second immiscible silicic melt containing (in wt%, volatile free) SiO2 = 68.8, Al2O3 = 12.6, CaO = 3.7, MgO = 2.4, Na2O = 1.1, and K2O = 11.3 appears at 1250 °C. Both melts remain stable up to 1500 °C and coexist with the clinopyroxene ± garnet ± coesite residue. In the presence of water stored away in phengite, the melting begins with silicic melt, which contains (in wt%, volatile free) SiO2 = 61.4, Al2O3 = 15.3, CaO = 4.8, MgO = 3.0, Na2O = 2.2, and K2O = 13.3, and coexists with phengite, dolomite, clinopyroxene, and coesite. The phengite + dolomite assemblage remains to 1100 °C and disappears at 1200 °C producing two immiscible melts carbonatitic with approximate composition, 19(K0.89Na0.11)2CO3⋅81Ca0.57Mg0.43CO3, and silicic containing (in wt%, volatile free) SiO2 = 63.3, Al2O3 = 15.6, CaO = 4.5, MgO = 3.0, Na2O = 2.0, K2O = 11.6. The present results imply that partial melting of continental material subducted to a depth of 200 km can yield simultaneous formation of two immiscible melts, K-dolomitic and K-aluminosilicate. Under dry conditions, carbonatitic melt appears earlier (at a lower temperature). Given the low density and high mobility of this melt, it must rapidly percolate upward, leaving a refractory eclogite-like residue and leaving no chance for the formation of a second aluminosilicate melt. However, under hydrous conditions silicate melt appears earlier than carbonatitic melt, leaving a phengite- and dolomite-bearing residue, which finally yields the formation of two immiscible silicic and carbonatitic melts. The compositions of these melts fall in the compositional range of carbonatitic and silicic high-density fluids (HDFs) in diamonds worldwide. Thus, we suggest that the presence of water is a necessary requirement for the formation of immiscible HDFs inclusions in diamonds, and this suggestion is strongly supported by natural data from HDFs.
Major and trace element composition of olivine from magnesian skarns and silicate marbles
Authors: Nekrylov Nikolai , Plechov Pavel Yu. , Gritsenko Yulia D. , Portnyagin Maxim V. , Shcherbakov Vasily D. , Aydov Vasily A. , Garbe-Schönberg Dieter 
Published: July 2020

Abstract
Olivine is a major rock-forming mineral in various magmatic and metamorphic rocks and the upper mantle. In this paper, we present the first high-precision analyses of olivine from 15 samples of magnesian skarns and silicate marbles (MSSM) from the collection of the Fersman Mineralogical Museum (Moscow, Russia). Mg# [Mg/(Mg+Fe2+)·100, mol%] of olivine from the samples studied varies from 86 to nearly 100. The main distinctive features of the olivine are anomalously low contents of Co (&lt;51 mg/g), Cr (&lt;5 mg/g), and Ni (&lt;44 mg/g) and high content of B (23–856 mg/g), which correlate with host-rock compositions. Phosphorus (5–377 mg/g) incorporation in olivine is charge balanced by the incorporation of Li (0.15–61 mg/g) and Na (&lt;14.3 mg/g). Y and REE contents exhibit positive correlations with Na, which suggests that REE incorporation into MSSM olivine could occur via charge-balanced coupled substitution with Na at low temperature and low aSiO2 conditions during MSSM formation. The documented compositional features of olivine from magnesian skarns and silicate marbles can help reconstruct the genesis of the host-rocks and identify xenocrysts of MSSM olivine in magmatic rocks.
Uji Adsorpsi Bentonit Teraktivasi KOH Terhadap Logam Cu(II)
Authors: Fauziyati Mega Roikhanah 
Published: July 2020

<p class="E-JournalAbstractBodyIndo">Peningkatan perkembangan industri setiap tahun menyebabkan limbah cair yang dihasilkan semakin meningkat. Limbah yang tidak mengalami pengolahan menyebabkan pencemaran lingkungan. Salah satu upaya untuk mengurangi kadar ion logam dalam limbah yaitu meminimalisir kandungan ion logam berat menggunakan metode adsorpsi. Penelitian ini bertujuan mempelajari pengaruh proses aktivasi pada bentonit dengan menggunakan KOH dan mengaplikasikannya sebagai adsorben ion logam Cu(II). Parameter yang digunakan pada penelitian ini adalah variasi konsentrasi aktivator KOH, waktu optimum dan pH. Selain itu studi kinetika adsorpsi juga dipelajari dalam penelitian ini. Hasil penelitian menunjukkan adsorben terbaik adalah bentonit teraktivasi KOH 6M. Karakteristik bentonit ditandai dengan munculnya gugus spesifik Si-O dan Si-O-Si pada panjang gelombang 1009,31 cm<sup>-1</sup> dan 466,71 cm<sup>-1</sup>, munculnya difaktogram khas montmorillonit pada intensitas 2 = 20,880<sup>o</sup> (d=4,508 Å), luas permukaan spesifik 87,2001 m<sup>2</sup>/g dengan kapasitas adsorpsi 50,013 mg/g. Kondisi optimum waktu kontak adalah 120 menit pada konsentrasi awal ion logam Cu(II) 1000 ppm 50 ml. Adsorpsi ini mengikuti model kinetika pseudo orde dua dengan konstanta laju adsorpsi ion logam Cu(II) sebesar 9,08 x 10<sup>-4</sup> g.mg<sup>-1</sup>.</p>
Comparison of the Effects of Fenugreek Vaginal Cream and Ultra Low- Dose Estrogen on Atrophic Vaginitis
Authors: Safary Maryam , Hakimi Sevil , Mobaraki-Asl Noushin , Amiri Paria , Tvassoli Habib , Delazar Abbas 
Published: July 2020

Introduction:
Atrophic vaginitis is a common problem in postmenopausal women and results
from decreased levels of blood estrogen. It is associated with symptoms of itching, burning,
dyspareunia, and postmenopausal bleeding. The present study evaluated the effects of fenugreek extract
on atrophic vaginitis.

Materials and Methods:
This randomized controlled clinical trial was performed on 60 postmenopausal
women in Ardabil, Iran, in 2018. The participants were selected using block randomization with the
allocation ratio 1:1. Those in the intervention group received 0.5g (the applicator filled to the half-full
mark) fenugreek vaginal cream 5% twice a week for 12 weeks. The control group received conjugated
estrogens vaginal cream at the dose of 0.625 mg (the applicator filled to the half-full mark) containing
0.3 mg of conjugated estrogens. Atrophic vaginitis was evaluated before and after the treatment through
clinical examination, clinical signs, and measurement of Vaginal Maturation Index (VMI).

Findings:
After the 12-week intervention and modification of the baseline score, the mean (standard
error) score for atrophic vaginitis signs was 3.100 (1.43-4.75). This difference was statistically significant
in intragroup comparison and in favor of the control group in intergroup comparison (p=0.001).
VMI was less than 49% in 86.7% and 46.7% of the participants in the intervention and control groups,
respectively. This was a significant difference in favor of the control group (p=0.001).

Conclusion:
The results of this study showed that total fenugreek extract could be effective in treating
signs of atrophic vaginitis, but it was not as effective as ultra-low-dose estrogen.
Preparation of β-CD–Quercetin Complex and its Effects on Ethanol- Damaged BRL-3A Hepatocytes
Authors: Zhang Yingxia , Lin Xiao , Wang Jinglong , Jing Sun , Wang Deya , Tian Zhongjing , Kang Meiling , Ding Chengshi , He Shishui , Ma Jing 
Published: July 2020

Objective:
To prepare the sustained-release complex, quercetin was incorporated with β-
cyclodextrin (β-CD) and the effect of β-CD–quercetin complex on the growth of ethanol-injuried
hepatocytes was studied.

Methods:
By using scanning electron microscopy, infrared spectroscopy, and release rate analysis, β-
CD–quercetin complex was identified. The effect of different concentrations of β-CD–quercetin complex
on the growth of ethanol-damaged hepatocytes at different time was observed by using MTT assay,
and the cell quantity and morphology were observed by using hematoxylin–eosin staining. By using
single-cell gel electrophoresis, the prevention of β-CD–quercetin complex from the DNA damage of
ethanol-damaged BRL-3A cells was studied, and Olive tail moment was calculated.

Results:
β-CD–quercetin complex as the sustained-release complex was successfully prepared. The
ethanol induced damage of BRL-3A cells could be prevented by 20, 40 and 80 mg/L of quercetin complex,
and the protection mechanism of hepatocyte was related to the antioxidation of DNA.

Conclusion:
Quercetin sustained-release complex could be prepared with β-CD, and it might be used to
treat alcoholic liver disease.