bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-κB Signaling Pathways in Rats
Authors: Wang Jinxiang , Chen Zhiguo , Hou Shike , Liu Ziquan , Lv Qi 
Published: September 2020

AbstractBackground:To investigate if toll-like receptor (TLR) 4/nuclear factor-kappa B (NF-κB) signaling pathways mediated crush injury induced acute kidney injury (AKI) in rats, and if TAK-242 (a specific inhibitor of TLR4) attenuates the injury through inhibiting the signaling pathways.Methods:This study was divided into two parts: (1) Establish the crush injury model: 50 rats were randomly divided into control group and four crush injury groups (n = 10/group). Crush injury groups were given 3kg pressure for eight hours and were sacrificed at the time points of 0h, 6h, 12h, and 24h after relieving pressure. And (2) Select the most obvious injury group (12h group) for drug intervention group. Thirty rats were randomly divided into control group, 12h group, and 12h+TAK-242 group (n = 10/group). Two parts detection were as follows: pathological changes of kidney tissues were observed in Haematoxylin and Eosin (HE) staining. Serum creatinine, blood urea nitrogen (BUN), myoglobin (Mb), and blood potassium were examined by automatic biochemical analysis instrument. Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA). The TLR4 messenger ribonucleic acid (mRNA), TLR4, and P65 were detected by real-time polymerase chain reaction (PCR), western blot, immunohistochemistry staining.Results:Compared with the control group, kidney tissues were damaged in crush injury groups, and most obvious in the 12h group. The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-α, and TLR4mRNA were increased in the crush injury groups and significantly increased in the 12h group (P <.05). The TLR4 and P65 were significantly increased in the 12h group (P <.05). Compared with the 12h group, kidney tissue damage was significantly reduced in the TAK-242 group (P <.05). The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-α, TLR4mRNA, TLR4, and P65 in the TAK-242 group were significantly reduced (P <.05).Conclusion:The present findings conclude that TLR4/NF-κB signaling pathways mediated crush injury induced AKI in rats, and TAK-242 attenuates the injury through inhibiting the signaling pathways.
Elite cueing and attitudes towards trade agreements: the case of TTIP
Authors: Dür Andreas , Schlipphak Bernd 
Published: September 2020

AbstractHow does elite communication affect citizens’ attitudes towards trade agreements? Building on a growing literature on context factors influencing public opinion about trade and trade agreements; we argue that citizens rely on cues provided by political elites, especially political parties, when forming their views towards these agreements. Such cueing effects are most likely for citizens with little information about a trade agreement and for citizens receiving cues from trusted elites. In addition, citizens exposed to cues from non-trusted elites should exhibit a source-opposing effect. Our key contribution is to test these expectations relying on a survey experiment on the Transatlantic Trade and Investment Partnership (TTIP) carried out in Germany and Spain. The findings from our experiment support the existence of elite cueing effects, although to a limited degree. Overall, the paper contributes to a better understanding of public opinion towards TTIP, trade policy attitudes, and public opinion more generally.
A Primer on the Vertical Lagrangian‐Remap Method in Ocean Models Based on Finite Volume Generalized Vertical Coordinates
Authors: Griffies Stephen M. , Adcroft Alistair , Hallberg Robert W. 
Published: September 2020

AbstractThis paper provides a primer on the mathematical, physical, and numerical foundations of ocean models that are formulated using finite volume generalized vertical coordinate equations and that use the vertical Lagrangian‐remap method to evolve the ocean state. We consider the mathematical structure of the governing ocean equations in both their strong formulation (partial differential equations) and weak formulation (finite volume integral equations), thus enabling an understanding of their physical content and providing a physical‐mathematical framework to develop numerical algorithms. A connection is made between the Lagrangian‐remap method and the ocean equations as written using finite volume generalized vertical budgets. Thought experiments are offered to exemplify the mechanics of the vertical Lagrangian‐remap method and to compare with other methods used for ocean model algorithms.
Modeling Non‐Fickian Solute Transport Due to Mass Transfer and Physical Heterogeneity on Arbitrary Groundwater Velocity Fields
Authors: Hansen Scott K. , Berkowitz Brian 
Published: September 2020

AbstractWe present a hybrid approach to groundwater transport modeling, “CTRW‐on‐a‐streamline,” that allows continuous‐time random walk (CTRW) particle tracking on large‐scale, explicitly delineated heterogeneous groundwater velocity fields. The combination of a non‐Fickian transport model (in this case, the CTRW) with general heterogeneous velocity fields represents an advance of the current state of the art, in which non‐Fickian transport models or heterogeneous velocity fields are employed but generally not both. We present a general method for doing this particle tracking that fully separates the model parameters characterizing macroscopic flow, subscale advective heterogeneity, and mobile‐immobile mass transfer, such that each can be directly specified a priori from available data. The method is formalized and connections to classic CTRW and subordination approaches are made. Numerical corroboration is presented.
Pb‐Pb Dating of Terrestrial and Extraterrestrial Samples Using Resonance Ionization Mass Spectrometry
Authors: Anderson F. Scott , Crow Carolyn , Levine Jonathan , Whitaker Tom J. 
Published: September 2020

AbstractWe are developing an in situ, rock‐dating spectrometer for spaceflight called the Chemistry, Organics, and Dating EXperiment (CODEX). CODEX will measure Rb‐Sr compositions and determine ages of samples on the Moon or Mars and can be augmented to obtain Pb‐Pb ages. Coupling Rb‐Sr and Pb‐Pb measurements broadens the suite of samples that can be dated and could provide tests of concordance. Here we assess whether geochronologically meaningful Pb‐Pb data could be measured in situ by tuning the prototype CODEX to acquire Pb‐Pb data from a suite of well‐characterized specimens from the Earth, Moon, and Mars. For Keuhl Lake Zircon 91500 our207Pb/206Pb age of 1,090 ± 40 Ma is indistinguishable from the accepted age. In each of the Martian meteorites we studied, we could not resolve more than a single component of Pb and could not uniquely determine ages; nevertheless, our isotopic measurements were consistent with most previous analyses. On the other hand, we uniquely determined ages for three lunar meteorites. Our age for MIL 05035 is 3,550 ± 170 Ma, within 2σ of published ages for this specimen, in spite of it having <1 ppm Pb. LAP 02205 was contaminated by terrestrial Pb, but by filtering our data to exclude the most contaminated spots, we obtained an age of 3,010 ± 70 Ma, coincident with published values. Finally, our age for NWA 032 is nearly 1,000 Ma older than its age determined from other isotopic systems and is supported by additional Pb measurements made after chemical leaching.
Comparative Assessment of Snowfall Retrieval From Microwave Humidity Sounders Using Machine Learning Methods
Authors: Adhikari Abishek , Ehsani Mohammad Reza , Song Yang , Behrangi Ali 
Published: September 2020

AbstractAccurate quantification of snowfall rate from space is important but has remained difficult. Four years (2007–2010) of NOAA‐18 Microwave Humidity Sounder (MHS) data are trained and tested with snowfall estimates from coincident CloudSat Cloud Profiling Radar (CPR) observations using several machine learning methods. Among the studied methods, random forest using MHS (RF‐MHS) is found to be the best for both detection and estimation of global snowfall. The RF‐MHS estimates are tested using independent years of coincident CPR snowfall estimates and compared with snowfall rates from Modern‐Era Retrospective analysis for Research and Applications Version 2 (MERRA‐2), Atmospheric Infrared Sounder (AIRS), and MHS Goddard Profiling Algorithm (GPROF). It was found that RF‐MHS algorithm can detect global snowfall with approximately 90% accuracy and a Heidke skill score of 0.48 compared to independent CloudSat samples. The surface wet bulb temperatures, brightness temperatures at 190 GHz, and 157 GHz channels are found to be the most important features to delineate snowfall areas. The RF‐MHS retrieved global snowfall rates are well compared with CPR estimates and show generally better statistics than MERRA‐2, AIRS, and GPROF products. A case study over the United States verifies that the RF‐MHS estimated snowfall agrees well with the ground‐based National Center for Environmental Prediction (NCEP) Stage‐IV and MERRA‐2 product, whereas a relatively large underestimation is observed with the current GPROF product (V05). MHS snowfall estimated based on RF algorithm, however, shows some underestimation over cold and snow‐covered surfaces (e.g., Greenland, Alaska, and northern Russia), where improvements through new sensors or retrieval techniques are needed.
Lithospheric Boundaries and Upper Mantle Structure Beneath Southern Africa Imaged by P and S Wave Velocity Models
Authors: White‐Gaynor A. L. , Nyblade A. A. , Durrheim R. , Raveloson R. , van der Meijde M. , Fadel I. , Paulssen H. , Kwadiba M. , Ntibinyane O. , Titus N. , Sitali M. 
Published: September 2020

AbstractWe report new P and S wave velocity models of the upper mantle beneath southern Africa using data recorded on seismic stations spanning the entire subcontinent. Beneath most of the Damara Belt, including the Okavango Rift, our models show lower than average velocities (−0.8% Vp; −1.2% Vs) with an abrupt increase in velocities along the terrane's southern margin. We attribute the lower than average velocities to thinner lithosphere (~130 km thick) compared to thicker lithosphere (~200 km thick) immediately to the south under the Kalahari Craton. Beneath the Etendeka Flood Basalt Province, higher than average velocities (0.25% Vp; 0.75% Vs) indicate thicker and/or compositionally distinct lithosphere compared to other parts of the Damara Belt. In the Rehoboth Province, higher than average velocities (0.3% Vp; 0.5% Vs) suggest the presence of a microcraton, as do higher than average velocities (1.0% Vp; 1.5% Vs) under the Southern Irumide Belt. Lower than average velocities (−0.4% Vp; −0.7% Vs) beneath the Bushveld Complex and parts of the Mgondi and Okwa terranes are consistent with previous studies, which attributed them to compositionally modified lithosphere resulting from Precambrian magmatic events. There is little evidence for thermally modified upper mantle beneath any of these terranes which could provide a source of uplift for the Southern African Plateau. In contrast, beneath parts of the Irumide Belt in southern and central Zambia and the Mozambique Belt in central Mozambique, deep‐seated low velocity anomalies (−0.7% Vp; −0.8% Vs) can be attributed to upper mantle extensions of the African superplume structure.
The Christmas 2018 Eruption at Mount Etna: Enlightening How the Volcano Factory Works Through a Multiparametric Inspection
Authors: Borzi Alfio Marco , Giuffrida Marisa , Zuccarello Francesco , Palano Mimmo , Viccaro Marco 
Published: September 2020

AbstractThe 24–27 December 2018 flank eruption at Mount Etna (Southern Italy) has been investigated through a multidisciplinary approach in which olivine chemical zoning and diffusion chronometry data were integrated with models inferred by GNSS (Global Navigation Satellite System) measurements. Inspection of the olivine chemical zoning from core to rim allowed the identification of some dominant ways of transfer and interaction between magmas pertaining to different magmatic environments. Most of crystal cores are representative of crystallization at pressure of 290–230 and 160–120 MPa. Olivine rims suggest re‐equilibration at shallow pressure (≤30 MPa). Geodetic‐based models indicate pressurization of near‐vertical prolate spheroidal sources centered at ∼7.2 km below sea level (bsl) between 9 June 2017 and 28 June 2018 and later at ∼5.1 km bsl between 28 June 2018 and the eruption onset. Geodetic data also highlight a change in the inflation rate since late June 2018 and later around November 2018, which has been here related to both replenishment phases and magma uprising across the plumbing system. Timescales of magma replenishment are in agreement with prolonged recharge from deep levels upward to shallow environments started about 6 months before the eruption, with further replenishment involving the upper magmatic environments just 3–16 days before the eruption. At present, the eruptive activity at the volcano is primarily controlled by pressure imbalances affecting extensive sections of the plumbing system, with possibility to develop persistent eruptive activity at the summit versus flank eruptions depending on fortuitous interruptions of the steady magma recharge/discharge rate at shallow levels.
Neutral Atom Imaging of the Solar Wind‐Magnetosphere‐Exosphere Interaction Near the Subsolar Magnetopause
Authors: Fuselier S. A. , Dayeh M. A. , Galli A. , Funsten H. O. , Schwadron N. A. , Petrinec S. M. , Trattner K. J. , McComas D. J. , Burch J. L. , Toledo‐Redondo S. , Szalay J. R. , Strangeway R. J. 
Published: September 2020

AbstractEnergetic neutral atoms (ENAs) created by charge‐exchange of ions with the Earth's hydrogen exosphere near the subsolar magnetopause yield information on the distribution of plasma in the outer magnetosphere and magnetosheath. ENA observations from the Interstellar Boundary Explorer (IBEX) are used to image magnetosheath plasma and, for the first time, low‐energy magnetospheric plasma near the magnetopause. These images show that magnetosheath plasma is distributed fairly evenly near the subsolar magnetopause; however, low‐energy magnetospheric plasma is not distributed evenly in the outer magnetosphere. Simultaneous images and in situ observations from the Magnetospheric Multiscale (MMS) spacecraft from November 2015 (during the solar cycle declining phase) are used to derive the exospheric density. The ~11–17 cm−3 density at 10 RE is similar to that obtained previously for solar minimum. Thus, these combined results indicate that the exospheric density 10 RE from the Earth may have a weak dependence on solar cycle.
Impact of Mineral Dust on Summertime Precipitation Over the Taiwan Region
Authors: Zhang Yanda , Yu Fangqun , Luo Gan , Chen Jen‐Ping , Chou Charles C.‐K. 
Published: September 2020

AbstractDust particles are effective ice nuclei and are known to affect precipitation. Here, the possible impacts of mineral dust on summertime cloud and precipitation over the Taiwan region are investigated through analysis of 25 years (1989–2013) of multiple observational and modeling data sets. Due to the unique mechanism, typhoon precipitations are excluded from this study. Statistical methods (partial correlation and stratification) are used to untangle the influences of dust from the covarying meteorological conditions (water vapor, horizontal wind, sea surface temperature, and moisture flux). The results suggest a statistically significant positive correlation between nontyphoon precipitation and the number concentration of dust particles larger than 0.5 μm (Nd) in July and August in the regions with heavy precipitation. From clean (Nd = ~0.008 cm−3) to dusty days (Nd = ~0.2 cm−3), averaged ice (liquid) water paths and precipitation increase by ~25% (~20%) and ~70% over the orographic region, and vertically, ~30% more cloud ice content is generated at ~350 hPa (T = ~ −20°C), enhancing the development of the mixed‐phase cloud and precipitation. The results also indicate the critical role of the atmospheric water vapor in the responses of precipitation to Nd, with precipitation increasing more significantly with Nd in higher water vapor circumstances.
Fluvial Sinuous Ridges of the Morrison Formation, USA: Meandering, Scarp Retreat, and Implications for Mars
Authors: Hayden A. T. , Lamb M. P. 
Published: September 2020

AbstractSinuous ridges have been interpreted as evidence for ancient rivers on Mars, but relating ridge geometry to paleo‐hydraulics remains uncertain. Three analog ridge systems from the Morrison Formation, Utah, are composed of sandstone caprocks, up to 50 m wide and 8 m thick, atop mudstone flanks. Ridge caprocks have narrowed significantly compared to sandstone bodies preserved in outcrop, consistent with a new ridge‐erosion model that can be used to estimate original sandstone‐body extent. Ridge networks represent caprocks intersecting at distinct stratigraphic levels, rather than a preserved channel network. Caprocks are interpreted as amalgamated channel belts, rather than inverted channels, with dune and bar cross stratification that was used to reconstruct paleo‐channel dimensions. Curvilinear features on ridge tops are outcropping lateral accretion sets (LAS) from point bars and indicate meandering. We found that caprock thickness scales with paleo‐channel depth and LAS curvature scales with paleo‐channel width. Application of these relations to a ridge in Aeolis Dorsa, Mars, yielded consistent water discharge estimates (310–1,800 m3/s). In contrast, using ridge width or ridge radius of curvature as paleo‐channel proxies overestimated discharge by a factor of 30–500. In addition, the ridge‐erosion model suggests that scarp retreat may be less efficient on Mars, resulting in taller and wider ridges, with more intact caprocks. Altogether, our results support the hypothesis that ridges are exhumed channel belts and floodplain deposits implying long‐lived fluvial activity recorded within a depositional basin.
Data‐Driven Reservoir Simulation in a Large‐Scale Hydrological and Water Resource Model
Authors: Turner Sean W. D. , Doering Kenji , Voisin Nathalie 
Published: September 2020

AbstractLarge‐scale hydrological and water resource models (LHMs) are used increasingly to study the vulnerability of human systems to water scarcity. These models rely on generic reservoir release schemes that often fail to capture the nuances of operations at individual dams. Here we assess whether empirically derived release‐availability functions tailored to individual dams could improve the simulation performance of an LHM. Seasonally varying, linear piecewise relations that specify water release as a function of prevailing storage levels and forecasted future inflow are compared to a common generic scheme for 36 key reservoirs of the Columbia River Basin. When forced with observed inflows, the empirical approach captures observed release decisions better than the generic scheme—including under conditions of drought. The inclusion of seasonally varying inflow forecasts used by reservoir operators adds further improvement. When exposed to biases and errors inherent in the LHM, data‐driven policies fail to offer a robust improvement; inclusion of forecasts deteriorates LHM reservoir simulation performance in some cases. We perform sensitivity analysis to explain this result, finding that the bias inherent in LHM streamflow is amplified by a reservoir model that relies on forecasts. To harness the potential of interpretable, data‐driven reservoir operating schemes, research must address LHM flow biases arising from inaccuracies in climate input, runoff generation, flow routing, and water withdrawal and consumption data.
A novel SOX10 variant in a Japanese girl with Waardenburg syndrome type 4C and Kallmann syndrome
Authors: Hamada Junpei , Ochi Fumihiro , Sei Yuka , Takemoto Koji , Hirai Hiroki , Honda Misa , Shibata Hironori , Hasegawa Tomonobu , Eguchi Mariko 
Published: September 2020

AbstractWe report the first case of Waardenburg syndrome type 4C and Kallmann syndrome in the same person. The patient, a Japanese girl, presented with bilateral iris depigmentation, bilateral sensorineural hearing loss, Hirschsprung disease, hypogonadotropic hypogonadism, and anosmia. We identified a novel SOX10 variant, c.124delC, p.Leu42Cysfs*67.
Giant voltage-induced modification of magnetism in micron-scale ferromagnetic metals by hydrogen charging
Authors: Ye Xinglong , Singh Harish K. , Zhang Hongbin , Geßwein Holger , Chellali Mohammed Reda , Witte Ralf , Molinari Alan , Skokov Konstantin , Gutfleisch Oliver , Hahn Horst , Kruk Robert 
Published: September 2020

AbstractOwing to electric-field screening, the modification of magnetic properties in ferromagnetic metals by applying small voltages is restricted to a few atomic layers at the surface of metals. Bulk metallic systems usually do not exhibit any magneto-electric effect. Here, we report that the magnetic properties of micron-scale ferromagnetic metals can be modulated substantially through electrochemically-controlled insertion and extraction of hydrogen atoms in metal structure. By applying voltages of only ~ 1 V, we show that the coercivity of micrometer-sized SmCo5, as a bulk model material, can be reversibly adjusted by ~ 1 T, two orders of magnitudes larger than previously reported. Moreover, voltage-assisted magnetization reversal is demonstrated at room temperature. Our study opens up a way to control the magnetic properties in ferromagnetic metals beyond the electric-field screening length, paving its way towards practical use in magneto-electric actuation and voltage-assisted magnetic storage.
Rapid vessel segmentation and reconstruction of head and neck angiograms using 3D convolutional neural network
Authors: Fu Fan , Wei Jianyong , Zhang Miao , Yu Fan , Xiao Yueting , Rong Dongdong , Shan Yi , Li Yan , Zhao Cheng , Liao Fangzhou , Yang Zhenghan , Li Yuehua , Chen Yingmin , Wang Ximing , Lu Jie 
Published: September 2020

AbstractThe computed tomography angiography (CTA) postprocessing manually recognized by technologists is extremely labor intensive and error prone. We propose an artificial intelligence reconstruction system supported by an optimized physiological anatomical-based 3D convolutional neural network that can automatically achieve CTA reconstruction in healthcare services. This system is trained and tested with 18,766 head and neck CTA scans from 5 tertiary hospitals in China collected between June 2017 and November 2018. The overall reconstruction accuracy of the independent testing dataset is 0.931. It is clinically applicable due to its consistency with manually processed images, which achieves a qualification rate of 92.1%. This system reduces the time consumed from 14.22 ± 3.64 min to 4.94 ± 0.36 min, the number of clicks from 115.87 ± 25.9 to 4 and the labor force from 3 to 1 technologist after five months application. Thus, the system facilitates clinical workflows and provides an opportunity for clinical technologists to improve humanistic patient care.