bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers
Authors: Ghandhi Shanaz A. , Smilenov Lubomir , Shuryak Igor , Pujol-Canadell Monica , Amundson Sally A. 
Published: December 2019

AbstractThe mouse (Mus musculus) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g.CDKN1A, MDM2, BBC3, andCCNG1) or down-regulated (e.g.TCF4andMYC) in both species after irradiation at ~4 and 8 Gy. However, we have also found genes that are consistently up-regulated in humans and down-regulated in mice (e.g.DDB2, PCNA, GADD45A, SESN1, RRM2B, KCNN4, IFI30, andPTPRO). Here we test a hematopoietically humanized mouse as a potentialin vivomodel for biodosimetry studies, measuring the response of these 14 genes one day after irradiation at 2 and 4 Gy, and comparing it with that of human blood irradiatedex vivo, and blood from whole body irradiated mice. We found that human blood cells in the hematopoietically humanized mousein vivoenvironment recapitulated the gene expression pattern expected from human cells, not the pattern seen fromin vivoirradiated normal mice. The results of this study support the use of hematopoietically humanized mice as anin vivomodel for screening of radiation response genes relevant to humans.
PtdIns4P-mediated electrostatic forces influence S-acylation of peripheral proteins at the Golgi complex
Authors: Chumpen Ramirez Sabrina , Astrada Micaela R. , Daniotti Jose L. 
Published: December 2019

Abstract
Protein S-acylation is a reversible post-translational modification involving the addition of fatty acids to cysteines and is catalyzed by transmembrane protein acyltransferases (PATs) mainly expressed at the Golgi complex. In case of soluble proteins, S-acylation confers stable membrane attachment. Myristoylation or farnesylation of many soluble proteins constitutes the initial transient membrane adsorption step prior to S-acylation. However, some S-acylated soluble proteins, such as the neuronal growth-associated protein Growth-associated protein-43 (GAP-43), lack the hydrophobic modifications required for this initial membrane interaction. The signals for GAP-43 S-acylation are confined to the first 13 amino acids, including the S-acylatable cysteines 3 and 4 embedded in a hydrophobic region, followed by a cluster of basic amino acids. We found that mutation of critical basic amino acids drastically reduced membrane interaction and hence S-acylation of GAP-43. Interestingly, acute depletion of phosphatidylinositol 4-phosphate (PtdIns4P) at the Golgi complex reduced GAP-43 membrane binding, highlighting a new, pivotal role for this anionic lipid and supporting the idea that basic amino acid residues are involved in the electrostatic interactions between GAP-43 and membranes of the Golgi complex where they are S-acylated.
Conversational Language in 3-Year-Old Children Born Very Preterm and at Term
Authors: Sanchez Katherine , Spittle Alicia J. , Boyce Jessica O. , Leembruggen Linda , Mantelos Anastasia , Mills Stephanie , Mitchell Naomi , Neil Emily , John Miya St , Treloar Jasmin , Morgan Angela T. 
Published: December 2019

Purpose
Language difficulties are prevalent among children born preterm. Existing studies have largely used standardized language tests, providing limited scope for detailed descriptive examination of preterm language. This study aimed to examine differences in conversational language between children born < 30 weeks and at term as well as correlations between language sample analysis (LSA) and a standardized language tool.

Method
Two hundred four 3-year-olds (103 born < 30 weeks, 101 born at term) recruited at birth provided a 10-min language sample and completed the Preschool Language Scales–Fifth Edition (I. Zimmerman, Steiner, & Pond, 2011). LSA was conducted using the Systematic Analysis of Language Transcripts and Index of Productive Syntax. Group differences were analyzed using linear regression, and Pearson correlation coefficient (coef) was used to determine correlations between measures.

Results
Children born < 30 weeks scored lower than term-born peers on multiple metrics when controlled for confounding factors (sex, high social risk, multilingualism, and diagnosed neurodevelopmental disorders), including mean length of utterance in morphemes (coef = –0.28, 95% confidence interval [CI] [–0.56, 0.01]) and words (coef = –0.29, 95% CI [–0.53, –0.05]), number of different word roots (coef = –10.04, 95% CI [–17.93, –2.14]), and Index of Productive Syntax sentence structures (coef = –1.81, 95% CI [–3.10, –0.52]). Other variables (e.g., number of utterances, number of nouns and adjectives) were not significantly different between groups. LSA and the Preschool Language Scales–Fifth Edition were at most moderately correlated (≤ .45).

Conclusions
Three-year-old children born preterm demonstrated poorer conversational language than children born at term, with some specific areas of deficit emerging. Furthermore, formal assessment and LSA appear to provide relatively distinct and yet complementary data to guide diagnostic and intervention decisions.

Supplemental Material

https://doi.org/10.23641/asha.11368073
Performance evaluation of RQ non‐parametric CFAR detector in multiple target and non‐uniform clutter
Authors: Meng Xiangwei 
Published: December 2019

The performance analysis of the rank quantisation (RQ) non‐parametric constant false alarm rate (CFAR) detector in homogeneous and non‐homogeneous backgrounds is carried out. A closed‐form expression of the false alarm rate of the RQ detector at clutter edges is derived. It is shown that the RQ detector pays an additional loss of about 3 dB in detection performance relative to the cell averaging (CA)‐CFAR with incoherent integration in homogeneous background, but it can accommodate a number of strong interfering targets within the reference window. When both of the heavy and the weak clutters follow a Rayleigh distribution, the rise of false alarm rate for the RQ detector at clutter edges lies between that of the CA‐CFAR and the ordered statistic (OS)‐CFAR with incoherent integration. If the Weibull distributed clutter with a long tail moves into the reference window, the rise of the false alarm rate of the CA‐CFAR, the OS‐CFAR and the greatest‐of‐CFAR with incoherent integration reaches a peak of more than three orders of magnitude, and cannot return to the original design Pfa. However, the RQ detector reveals its inherent virtue that it can maintain a CFAR despite the changes in the underlying distributions of observed data.
The intergalactic medium transmission towards z ≳ 4 galaxies with VANDELS and the impact of dust attenuation
Authors: Thomas R. , Pentericci L. , Le Fevre O. , Zamorani G. , Schaerer D. , Amorin R. , Castellano M. , Carnall A. C. , Cristiani S. , Cullen F. , Finkelstein S. L. , Fontanot F. , Guaita L. , Hibon P. , Hathi N. , Fynbo J. P. U. , Khusanova Y. , Koekemoer A. M. , McLeod D. , McLure R. J. , Marchi F. , Pozzetti L. , Saxena A. , Talia M. , Bolzonella M. 
Published: December 2019

Aims. Our aim is to estimate the intergalactic medium (IGM) transmission towards UV-selected star-forming galaxies at z ≳ 4 and study the effect of the dust attenuation on these measurements.
Methods. The UV spectrum of high-redshift galaxies is a combination of their intrinsic emission and the effect of the IGM absorption along their line of sight. Using data coming from the unprecedentedly deep spectroscopy from the VANDELS ESO public survey carried out with the VIMOS instrument, we compute both the dust extinction and the mean transmission of the IGM as well as its scatter from a set of 281 galaxies at z >  3.87. Because of a degeneracy between the dust content of the galaxy and the IGM, we first estimate the stellar dust extinction parameter E(B − V) and study the result as a function of the dust prescription. Using these measurements as constraint for the spectral fit we estimate the IGM transmission Tr(Lyα). Both photometric and spectroscopic spectral energy distribution fits are performed using the SPectroscopy And photometRy fiTting tool for Astronomical aNalysis which is able to fit the spectral continuum of the galaxies as well as photometric data.
Results. Using the classical Calzetti attenuation law we find that E(B − V) goes from 0.11 at z = 3.99 to 0.08 at z = 5.15. These results are in very close agreement with published measurements. We estimate the IGM transmission and find that the transmission is decreasing with increasing redshift from Tr(Lyα) = 0.53 at z = 3.99 to 0.28 at z = 5.15. We also find a large standard deviation around the average transmission that is more than 0.1 at every redshift. Our results are in very good agreement with both previous measurements from AGN studies and with theoretical models.
Emotionale Dysbalance in der Menopause
Authors: Daling Dominik , Klass Elke , Hinze Katharina , Löwensprung Natalie Rosenhauer von 
Published: December 2019

SummaryVier Experten stellen die Behandlung von Emotionaler Dysbalance in der Menopause mithilfe der TCM, Homöopathie, Phytotherapie und Anthroposophie vor.
Zerebrovaskuläre Ereignisse, Kopfschmerzen und Livedo racemosa – Blickdiagnose?
Authors: Krämer Stefan , Richter Georg , Goldammer Uwe , Sindern Eckhart 
Published: December 2019

ZusammenfassungDas Sneddon-Syndrom ist eine seltene Erkrankung, gekennzeichnet durch zerebrovaskuläre Ereignisse und Livedo racemosa. Häufig bestehen autoimmunologische Komorbiditäten, insbesondere das Antiphospholipid-Antikörper-Syndrom. Die Pathophysiologie ist weiterhin nicht vollständig geklärt. Eine kausale Therapie existiert nicht. Der berichtete Fall zeigt eine Patientin mit einer thrombophilen Form des Sneddon-Syndroms mit den Leitsymptomen Kopfschmerz und thromboembolische Ereignisse. Es werden die Symptome, Laborparameter, Histologie und Differentialdiagnosen erläutert.
Medikamentöse Therapieoptionen der akuten Herzinsuffizienz
Authors: Flierl Ulrike , Bauersachs Johann 
Published: December 2019

ZusammenfassungDie akute Herzinsuffizienz ist eine lebensbedrohliche Erkrankung und geht oft mit einer Stauungskomponente einher. Anhand der klinischen Präsentation des Patienten muss die optimale Therapiestrategie zur akuten Stabilisierung entschieden werden. Diuretika sowie Vasodilatoren sind die Mittel der Wahl bei gestauten, normo- bis hypertensiven Patienten. Bei relevanter Hypotension sowie kardiogenem Schock kommen Vasopressoren sowie Inotropika zur Anwendung. Präferiert werden hier Noradrenalin sowie Dobutamin. Levosimendan, ein Kalzium-Sensitizer, bewirkt als Inotropikum Adrenorezeptor-unabhängig eine Erhöhung des Herzzeitvolumens sowie eine Vasodilatation und scheint im Gegensatz zu Katecholaminen/Vasopressoren nicht mit einer erhöhten Letalität assoziiert zu sein. Letztlich bleibt die Datenlage zu Inotropika, Vasopressoren und Vasodilatoren schwach, sodass die Anwendung lediglich eine kurzzeitige Überbrückung darstellt und eine frühe zielgerichtete Therapiestrategie im Vordergrund stehen sollte.
Aussichtslose Fälle? Ändere deine Sichtweise!
Authors: Gillhofer Heidi , Wagner Johannes 
Published: December 2019

ZUSAMMENFASSUNGEin 3-wöchiger Aufenthalt in einer Rehabilitationsklinik für Stoffwechselerkrankungen ermöglicht vieles, was ambulant nicht geschehen würde. Befreit von den Alltagsroutinen wie Arbeit und Haushalt, wird der Mensch aufnahmebereit für Neues. Motivationsaufbau und Selbstermächtigung verstärken sein gesundheitsförderliches Verhalten. Viele stellen ihre Bewegungs- und Ernährungsgewohnheiten sogar erfolgreich lebenslang um. Einigen Menschen ist dies jedoch nicht möglich. Hier geraten die Ärzte und Berater an ihre Grenzen, wenn der Patient zum wiederholten Male mit schlechtem HbA1c-Wert und unverändert adipös in der Reha auftaucht. Austherapiert und bedrohlich, hilft die 5. Wiederholung? Spätestens jetzt muss neben der klassisch medizinischen Behandlung auch der Behandlungskontext und die individuelle Bedeutungsreaktion Beachtung finden. Als Psychologin im Team greife ich nun auf den lösungsfokussierten Ansatz von De Jong und Berg zurück, um neben den zu erforschenden Schwierigkeiten die Freude auf die Zukunft zu wecken.
Kohlenhydratrestriktion bei Typ-2-Diabetes aus Sicht des Präventivmediziners
Authors: Johannes Scholl 
Published: December 2019

ZUSAMMENFASSUNGDie Verminderung der Kohlenhydratzufuhr im Austausch gegen mehr Eiweiß und Fett verbessert den Glukosestoffwechsel bei Typ-2-Diabetespatienten und kann in einem hohen Prozentsatz sogar eine Diabetesremission ermöglichen. Darüber hinaus bewirkt die Restriktion der Kohlenhydratzufuhr eine erhebliche Verbesserung der triglyzeridreichen Lipoproteine und damit des non-HDL-Cholesterins bei gleichzeitigem Anstieg des HDL-Cholesterins. Ein leichter Anstieg des LDL-Cholesterins ist durch die Zunahme der LDL-Partikelgröße bedingt, wohingegen die kleinen, dichten LDL-Partikel (sd-LDL) und das Apolipoprotein B als Maß für die Anzahl der LDL-Partikel abnehmen. Insgesamt zeigen Interventionsstudien mit Reduktion der Kohlenhydratzufuhr eine Verbesserung des kardiovaskulären Risikoprofils bei Typ-2-Diabetespatienten.
Von Niere und Dünndarm ins Becken
Authors: Blumbach Christian 
Published: December 2019

SummaryEin venöser Rückstau in der linken Vena testicularis/ovarica kann langfristig zu Leiden wie Fertilitätsstörungen und Dysmenorrhö führen. Eine Ptose der linken Niere oder des Dünndarms kann einen venösen Rückstau in der linken Vena testicularis / ovarica (mit)verursachen. Die osteopathische Behandlung des nierenassoziierten Rückstaus setzt an der Nierenfaszie an, die Behandlung des dünndarmassoziierten Rückstaus am Dünndarmpaket.
Wall Shear Stress Measurement by Ultrafast Vector Flow Imaging for Atherosclerotic Carotid Stenosis
Authors: Goudot Guillaume , Poree Jonathan , Pedreira Olivier , Khider Lina , Julia Pierre , Alsac Jean-Marc , Laborie Emeline , Mirault Tristan , Tanter Mickael , Messas Emmanuel , Pernot Mathieu 
Published: December 2019

Objective Carotid plaque vulnerability assessment could guide the decision to perform endarterectomy. Ultrafast ultrasound imaging (UF) can evaluate local flow velocities over an entire 2D image, allowing measurement of the wall shear stress (WSS). We aimed at evaluating the feasibility of WSS measurement in a prospective series of patients with carotid stenosis.
Methods UF acquisitions, performed with a linear probe, had an effective frame rate of 5000 Hz. The flow velocity was imaged over the entire plaque area. WSS was computed with the vector field speed using the formula:

with

the blood velocity and μ, the blood viscosity. The WSS measurement method was validated using a calibrated phantom. In vivo, WSS was analyzed in 5 areas of the carotid wall: common carotid artery, plaque ascent, plaque peak, plaque descent, internal carotid artery.
Results Good correlation was found between in vitro measurement and the theoretical WSS values (R2 = 0.95; p < 0.001). 33 patients were prospectively evaluated, with a median carotid stenosis degree of 80 % [75–85]. The maximum WSS value over the cardiac cycle follows the shape of the plaque with an increase during the ascent, reaching its maximum value of 3.25 Pa [2.26–4.38] at the peak of the plaque, and a decrease after passing of the peak (0.93 Pa [0.80–1.19]) lower than the WSS values in the non-stenotic areas (1.47 Pa [1.12–1.77] for the common carotid artery).
Conclusion UF allowed local and direct evaluation of the plaque’s WSS, thus better characterizing local hemodynamics to identify areas of vulnerability.
Key Points:
Die Nadel im Heuhaufen
Authors: Stör Wolfram 
Published: December 2019

SummaryEin persönlicher Bericht Geschichte der Ärztlichen Akupunkturim deutschsprachigen Raum aus Sicht des Autors.Er hat dieSituation seit Mitte der 1980er Jahre beobachtetund aktiv mitgestaltet.Der Bericht erhebt keinen Anspruch auf die vollständigeDarstellung des historischen Verlaufs. Er beschäftigt sichmit den Fragen auf welchen Fundamenten die Akupunkturim deutschsprachigenRaum ruht, wie die Etablierungausgerechnet der Akupunktur gelang und welcheAufgaben die Zukunft bereithält.
Associação do polimorfismo IL-6 -174G > C (rs1800795) com escoliose idiopática da adolescência: Evidências de um estudo de caso-controle e metanálise
Authors: Sobhan Mohammad Reza , Mahdinezhad-Yazdi Masoud , Dastgheib Seyed Alireza , Ahrar Hossein , Aghili Kazem , Neamatzadeh Hossein 
Published: December 2019

ResumoEstudos epidemiológicos recentes identificaram que o polimorfismo -174G > C (rs1800795) na região promotora do gene interleucina-6 (IL-6) está associado ao risco de desenvolver escoliose idiopática da adolescência (EIA), mas apresentaram resultados inconsistentes e controversos. Assim, realizamos um estudo de caso-controle e metanálise para obter uma estimativa mais precisa da relação entre o polimorfismo IL-6 -174G > C e o risco de desenvolver EIA. Um total de 80 pacientes com EIA e 80 controles saudáveis pareados foram genotipados usando o ensaio de reação em cadeia de polimerase de polimorfismos de comprimento de fragmentos de restrição (RCP-PCFR). Além disso, todos os estudos elegíveis publicados até junho de 2018 foram identificados por meio de uma pesquisa nas bases de dados PubMed, EMBASE, Google Scholar e China National Knowledge Infrastructure (CNKI). Calculamos as razões de probabilidades (RPs) e os intervalos de confiança de 95% (ICs95%) para avaliar a associação. Um total de 10 estudos elegíveis compreendendo 1.695 casos de EIA e 2.097 controles saudáveis foram incluídos na metanálise. Os dados agrupados sugeriram uma associação significativa entre o polimorfismo IL-6 -174G > C e a suscetibilidade a desenvolver EIA que foi demonstrada em quatro modelos genéticos, ou seja, alélico (C versus G; RP = 0,671; IC95%: 0,457–0,985; p = 0,042), heterozigótico (GC versus GG; RP = 0,734; IC95%: 0,554–0,973; p = 0,032), dominante (CC + GC versus GG; RP = 0,660; IC95%: 0,440–0,990; p = 0,044) e recessivo (CC versus CG + GG; RP = 0,506; IC95%: 0,264–0,970; p = 0,040). A análise de estratificação por etnia revelou um aumento do risco de desenvolver EIA em caucasianos, mas não em asiáticos. Esta metanálise, que é inconsistente com relação à metanálise anterior, sugere que o polimorfismo IL-6 -174G > C pode aumentar a suscetibilidade individual para desenvolver EIA, especialmente em caucasianos, e pode servir como um biomarcador para prever a população com alto risco de desenvolver EIA.
Estudo morfométrico do atlas
Authors: Filho Narcelio Mendes Ferreira , Arantes Ricardo , do Nascimento Anderson Luis , Herrero Carlos Fernando Pereira da Silva 
Published: December 2019

Resumo
Objetivo Determinar os parâmetros anatômicos do atlas (C1) em uma amostra da população brasileira, compará-los aos resultados já apresentados na literatura para outras populações e, assim, identificar e alterar as indicações dos implantes utilizados no tratamento das afecções da coluna cervical alta.
Métodos Foi realizado um estudo observacional retrospectivo de um banco de dados prospectivo, incluindo 100 pacientes atendidos entre janeiro de 2012 a dezembro de 2013. Foram utilizados cortes axiais e sagitais de tomografias computadorizadas (TCs). Os parâmetros estudados foram; axial: ponto de entrada do parafuso (DTPPE), ângulo de segurança (ADSPA), tamanho ideal do parafuso (TPA) e tamanho da massa lateral entre os forames vertebral e transverso (DCVFT); sagital: tamanho ideal do parafuso (TPS), ângulo de segurança (ADSPS) e espessura do arco posterior (EAP). Todos os parâmetros foram divididos de acordo com a idade, gênero e lado esquerdo e direito.
Resultados A média mínima do ponto de entrada variou de 20 mm a 22,7 mm. A zona de segurança média variou de 18,09° a 23,68°. A espessura média do arco posterior variou entre 7,21 mm e 8,95 mm. As menores médias foram encontradas no sexo feminino. Por meio de uma técnica original e reprodutível de avaliação de TC.
Conclusão Os parâmetros anatômicos do atlas encontrados na amostra da população estudada foram semelhantes aos apresentados previamente na literatura. No entanto, foram observadas diferenças entre os sexos.
Ressecção de tumor ósseo guiado por Gamaprobe e avaliação do quadro álgico pós-operatório
Authors: Gomes Alberto Ramos , Quatrin Felipe Younes , Becker Nadiane Maciel , Zanella Ruan Carlo , Rocha Thércio Murilo Souza 
Published: December 2019

ResumoO osteoma osteóide é uma neoplasia benigna comum em homens jovens; porém, pode atingir qualquer idade, acomete preferencialmente ossos longos, e é caracterizada por dor contínua e limitante que é aliviada por salicilatos. É uma lesão de tamanho pequeno, composta por tecido osteóide imaturo, hipervascularização central e área esclerótica circundante. O diagnóstico é realizado pela clínica e auxiliado por exames de imagem, como radiografia comum e tomografia computadorizada. À radiografia, apresenta-se como uma lesão radiolucente central e esclerose periférica. A biópsia está indicada somente nos casos de dúvida diagnóstica. O tratamento cirúrgico envolve a ressecção do nicho, proporcionando maior alívio sintomático, assim como as técnicas percutâneas. A técnica de ressecção guiada por radioisótopo tem boa aceitação na comunidade científica por tornar o procedimento cirúrgico mais rápido e dirigido para a lesão, ainda que o padrão ouro de tratamento seja a técnica percutânea de ablação por radiofrequência. É válido ressaltar que, no presente estudo, todos os pacientes submetidos à resecção cirúrgica apresentaram regressão do quadro álgico.
Estudo anatômico do túnel radial e suas implicações nas síndromes compressivas
Authors: Caetano Edie Benedito , Vieira Luiz Angelo , Sabongi Neto João José , Caetano Maurício Benedito Ferreira , Sabongi Rodrigo Guerra , Nakamichi Yuri da Cunha 
Published: December 2019

Resumo
Objetivo O objetivo do presente estudo foi analisar as estruturas contidas no túnel radial que podem causar neuropatia compressiva do nervo interósseo posterior.
Métodos Foram dissecados 30 membros de 15 cadáveres adultos, preparados por injeção intra-arterial de uma solução de glicerina e formol a 10%. Todos do sexo masculino, pertencentes ao laboratório de anatomia desta instituição.
Resultados O ramo para o músculo supinador originou-se do nervo interósseo posterior em todos os membros. Identificamos a arcada de Frohse com uma constituição fibrosa bem desenvolvida em 22 dos 30 membros dissecados (73%) e de constituição muscular em 8 (23%) A margem distal do músculo supinador apresentou consistência fibrosa em 7 dos 30 membros (23,5%) e uma aparência muscular em 23 (76,5%). Na margem proximal do músculo extensor radial curto do carpo, identificamos a arcada fibrosa em 18 membros (60%); em 9 (30%), notamos a arcada de constituição muscular; e em três (10%) havia apenas a inserção radial, de maneira que não formava a arcada.
Conclusão A arcada de Frohse e a arcada formada pelas origens do músculo extensor radial curto do carpo são estruturas anatômicas normais em cadáveres adultos. No entanto, sob o ponto de vista clínico, essas estruturas têm potencial para causar a compressão do nervo interósseo posterior.