bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnitude of reduction in risk of second contralateral breast cancer with bilateral mastectomy in patients with breast cancer: Data from California, 1998 through 2015
Authors: Kurian Allison W. , Canchola Alison J. , Ma Cindy S. , Clarke Christina A. , Gomez Scarlett L. 
Published: November 2019

BackgroundIncreasingly, patients with breast cancer undergo bilateral mastectomy (BLM). To the authors' knowledge, the magnitude of benefit is unknown.MethodsThe authors used data from the Surveillance, Epidemiology, and End Results (SEER) program regarding all women diagnosed with American Joint Committee on Cancer stage 0 to stage III unilateral breast cancer in California from 1998 through 2015 and treated with BLM versus breast‐conserving therapy including surgery and radiotherapy (BCT) or unilateral mastectomy (ULM). The authors measured relative risks of second contralateral breast cancer (CBC) and breast cancer death using Fine and Gray multivariable regression modeling adjusted for the competing risk of death and death from another cause, respectively, and potential confounding factors. Absolute excess risk of CBC was measured as the observed minus expected number of breast cancers in the general population divided by 10,000 person‐years at risk.ResultsAmong 245,418 patients with a median follow‐up of 6.7 years, 7784 patients (3.2%) developed CBC. Relative risks were lower after BLM (hazard ratio [HR], 0.10; 95% CI, 0.07‐0.14) and higher after ULM (HR, 1.07; 95% CI, 1.02‐1.13) versus BCT. Absolute excess risks were higher after BCT and ULM (5.0 and 13.6 more cases, respectively) compared with BLM (28.6 fewer cases). BLM reduced risk more among older women (38.0 fewer cases for women aged ≥50 years vs 17.9 fewer cases among women aged <50 years) but provided similar risk reduction across categories of tumor grade and tumor hormone receptor status. Compared with BCT, the risk of breast cancer death was equivalent after BLM (HR, 1.03; 95% CI, 0.96‐1.11) and higher after ULM (HR, 1.21; 95% CI, 1.17‐1.25).ConclusionsBLM may reduce second breast cancer risk by 34 to 43 cases per 10,000 person‐years compared with other surgical procedures, but is not associated with a lower risk of death. Second breast cancers are rare, and their reduction should be weighed against the harms associated with BLM.
Comparative neocortical neuromorphology in felids: African lion, African leopard, and cheetah
Authors: Nguyen Vivian T. , Uchida Riri , Warling Allysa , Sloan Lucy J. , Saviano Mark S. , Wicinski Bridget , Hård Therese , Bertelsen Mads F. , Stimpson Cheryl D. , Bitterman Kathleen , Schall Matthew , Hof Patrick R. , Sherwood Chet C. , Manger Paul R. , Spocter Muhammad A. , Jacobs Bob 
Published: November 2019

AbstractThe present study examines cortical neuronal morphology in the African lion (Panthera leo leo), African leopard (Panthera pardus pardus), and cheetah (Acinonyx jubatus jubatus). Tissue samples were removed from prefrontal, primary motor, and primary visual cortices and investigated with a Golgi stain and computer‐assisted morphometry to provide somatodendritic measures of 652 neurons. Although neurons in the African lion were insufficiently impregnated for accurate quantitative dendritic measurements, descriptions of neuronal morphologies were still possible. Qualitatively, the range of spiny and aspiny neurons across the three species was similar to those observed in other felids, with typical pyramidal neurons being the most prominent neuronal type. Quantitatively, somatodendritic measures of typical pyramidal neurons in the cheetah were generally larger than in the African leopard, despite similar brain sizes. A MARsplines analysis of dendritic measures correctly differentiated 87.4% of complete typical pyramidal neurons between the African leopard and cheetah. In addition, unbiased stereology was used to compare the soma size of typical pyramidal neurons (n = 2,238) across all three cortical regions and gigantopyramidal neurons (n = 1,189) in primary motor and primary visual cortices. Both morphological and stereological analyses indicated that primary motor gigantopyramidal neurons were exceptionally large across all three felids compared to other carnivores, possibly due to specializations related to the felid musculoskeletal systems. The large size of these neurons in the cheetah which, unlike lions and leopards, does not belong to the Panthera genus, suggests that exceptionally enlarged primary motor gigantopyramidal neurons evolved independently in these felid species.
Viewerphilic nightscape based on correlated color temperature
Authors: Pourfathollah Maedeh , Mahdavinejad Mohammadjavad 
Published: November 2019

AbstractNowadays, many factors are involved in lighting design to achieve targeted lighting in addition to meeting the user's requirements and security to avoid energy loss. As building indexation at night is one of the main reasons for building lighting, it is necessary to make a decision to reduce energy consumption and increase observer's attention. The present study investigated the relationship between the correlated color temperature of the background and building based on the amount of visual attention and the amount of visual desirability. In this article, using a factor analysis approach, a range that attracts visual attention and visual desirability at the same time was obtained, and it is called viewerphilic perspective. The results presented in the form of a diagram show a relationship between the variables that directly and indirectly influence the formation of a viewerphilic night perspective. The results showed that the elements with a high correlated color temperature in the background and a low correlated color temperature and neutral color were in the viewerphilic range, while the elements with a low color temperature and a background with a high color temperature was in the range of viewer phobic.
Using INTERSPIA to Explore the Dynamics of Protein‐Protein Interactions Among Multiple Species
Authors: Kwon Daehong , Lee Daehwan , Kim Juyeon , Lee Jongin , Sim Mikang , Kim Jaebum 
Published: November 2019

AbstractINTER‐Species Protein Interaction Analysis (INTERSPIA) is a web application for identifying diverse patterns of protein‐protein interactions (PPIs) in different species. Given a set of proteins of interest to the user, INTERSPIA first discovers additional proteins that are functionally associated with the input proteins as well as different or common patterns of PPIs among the proteins in multiple species through a server‐side pipeline. Second, it visualizes the dynamics of PPIs in multiple species via an easy‐to‐use web interface. This article contains a basic protocol describing how to visualize diverse patterns of PPIs of input proteins in multiple species, and how to use them for functional analysis in the web interface. INTERSPIA is freely available at http://bioinfo.konkuk.ac.kr/INTERSPIA/. © 2019 by John Wiley & Sons, Inc.Basic Protocol: Running INTERSPIA using a list of input proteins
Obsessive–compulsive symptoms in eating disorders: A network investigation
Authors: Meier Marieke , Kossakowski Jolanda J. , Jones Payton J. , Kay Brian , Riemann Bradley C. , McNally Richard J. 
Published: November 2019

AbstractObjectiveEating disorders (EDs) are complex, heterogeneous, and severe psychiatric syndromes. They are highly comorbid with obsessive–compulsive disorder (OCD) which exacerbates the course of illness and impedes treatment. However, the direct functional relations between EDs and OCD symptoms remain largely unexplored. Hence, using network analysis, we investigated the relationship between ED and OCD at the level of symptoms in a heterogeneous clinical sample.MethodWe used cross sectional data of 303 treatment‐seeking patients with clinically relevant ED and OCD pathology. We constructed a regularized partial correlation network that featured both ED and OCD symptoms as nodes. To determine each symptom's influence, we calculated expected influence (EI) as an index of symptom centrality (i.e., “importance”). Bridge symptoms (i.e., symptoms from one syndromic cluster that have strong connections to symptoms of another syndromic cluster) were identified by computing bridge expected influence metrics.ResultsFear of weight gain and dietary restraint were especially important among the ED symptoms. Interference due to obsessions was the key feature of OCD. ED and OCD clustered distinctly with few potential bridges between clusters.DiscussionThis study underscores the importance of cognitive symptoms for both ED and OCD although direct functional links between the two clusters are missing. Potentially, a network incorporating nodes capturing features of personality may account for diagnostic comorbidity better than specific symptoms of EDs or features of OCD do.
Declining freshwater mussel diversity in the middle and lower reaches of the Xin River Basin: Threat and conservation
Authors: Sun Weiwei , Liu Xiongjun , Wu Ruiwen , Wang Weikai , Wu Yanli , Ouyang Shan , Wu Xiaoping 
Published: November 2019

AbstractFreshwater mussels provide important functions and services for aquatic ecosystems, but populations of many species have been extirpated. Information on biodiversity plays an important role in the conservation and management of freshwater mussels. The Xin River Basin is a biodiversity hotspot for freshwater mussels in China, with more than 43 species known, but populations of which are decreasing. Here, we quantify the diversity of freshwater mussels in the middle and lower reaches of the Xin River Basin and study the correlation of habitat characteristics and freshwater mussel diversity. Compared to the historical period, the number of species, density, and biomass of freshwater mussels decreased 33%, 83%, and 82% in the current period, respectively. Fifty two percent of recorded species were empty shells, and 14 native freshwater mussels were not found in the study area. Four species are currently listed as vulnerable species using IUCN criteria and their global status. The assemblage structure of freshwater mussels exhibits significant spatial differences, and there was a correlation with substrate and physicochemical parameters. The main tributary of the Xin River with higher freshwater mussel diversity should be established as one large protected area because the nestedness component was the main pattern of beta diversity. These results indicated freshwater mussel diversity was declining rapidly, which can help focus conservation effort for freshwater mussel biodiversity.
Widespread severe wildfires under climate change lead to increased forest homogeneity in dry mixed‐conifer forests
Authors: Cassell Brooke A. , Scheller Robert M. , Lucash Melissa S. , Hurteau Matthew D. , Loudermilk E. Louise 
Published: November 2019

AbstractClimate warming in the western United States is causing changes to the wildfire regime in mixed‐conifer forests. Rising temperatures, longer fire seasons, increased drought, as well as fire suppression and changes in land use, have led to greater and more severe wildfire activity, all contributing to altered forest composition over the past century. To understand future interactions among climate, wildfire, and vegetation in a fire‐prone landscape in the southern Blue Mountains of central Oregon, we used a spatially explicit forest landscape model, LANDIS‐II, to simulate forest and fire dynamics under current management practices and two projected climate scenarios. The results suggest that wildfires will become more frequent, more extensive, and more severe under projected climate than contemporary climate. Furthermore, projected climate change generated a 20% increase in the number of extreme fire years (years with at least 40,000 ha burned). This caused large shifts in tree species composition, characterized by a decline in the sub‐alpine species (Abies lasiocarpa, Picea engelmannii, Pinus albicaulis) and increases in lower‐elevation species (Pinus ponderosa, Abies grandis), resulting in forest homogenization across the elevational gradient. This modeling study suggests that climate‐driven increases in fire activity and severity will make high‐elevation species vulnerable to decline and will reduce landscape heterogeneity. These results underscore the need for forest managers to actively consider climate change, altered fire regimes, and projected declines in sub‐alpine species in their long‐term management plans.
Local environmental factors influence beta‐diversity patterns of tropical fish assemblages more than spatial factors
Authors: López‐Delgado Edwin O. , Winemiller Kirk O. , Villa‐Navarro Francisco A. 
Published: November 2019

AbstractA major goal in ecology is to understand mechanisms that influence patterns of biodiversity and community assembly at various spatial and temporal scales. Understanding how community composition is created and maintained also is critical for natural resource management and biological conservation. In this study, we investigated environmental and spatial factors influencing beta diversity of local fish assemblages along the longitudinal gradient of a nearly pristine Neotropical river in the Colombian Llanos. Standardized surveys were conducted during the low‐water season at 34 sites within the Bita River Basin. Physical, chemical, and landscape parameters were recorded at each site, and asymmetric eigenvector maps were used as spatial variables. To examine the relative influence of dispersal and environmental variables on beta diversity and its components, distance‐based redundancy analysis (db‐RDA) and variation partitioning analysis were conducted. We proposed that spatial scale of analysis and position within the river network would constrain patterns of beta diversity in different ways. However, results indicated that in this system, high beta diversity was consistent among species assemblages no matter the scale of analysis or position within the river network. Species replacement (turnover) dominated beta diversity, an indication of the importance of species sorting. These findings suggested that conservation of fish diversity in tropical rivers requires maintenance of both habitat heterogeneity (spatial variation in habitat conditions) and connectivity at the scale of entire river basins.
Development of a Delonix regia decorticating machine
Authors: Ojolo S. J. , Orisaleye J. I. , Ogundare A. A. , Kadiri D. 
Published: November 2019

Delonix regia has good potential for medicinal, nutritional, and energy applications. However, the manual process of decorticating Delonix regia is labor‐intensive, slow, and tedious. Mechanization of the decorticating process would be of value to its utilization for medicinal, food, feed, or fuel purposes. In this study, preliminary compressive strength tests were carried out on the D. regia pods to determine the force required to fracture the pods. Subsequently, a machine capable of separating the D. regia seeds from the pods was designed based on impact of beaters on pods. A prototype of the developed machine was evaluated to determine its performance in terms of decorticating efficiency, whole seed recovery, feed rate, and throughput. The compressive tests showed that a force of 602 N was required to fracture the D. regia pods in transverse orientation. The decorticating efficiency of the designed machine, which had a power rating of 6 kW, was 100.0%, and the whole seed recovery was estimated to be 98.4%. The throughput of the machine was 56.4 kg/h. The developed decorticating machine allows enhanced potential for medicinal and nutritional application of D. regia.
Flours from Swedish pulses: Effects of treatment on functional properties and nutrient content
Authors: Ferawati Ferawati , Hefni Mohammed , Witthöft Cornelia 
Published: November 2019

AbstractDespite the high nutritional profile in pulses, pulse consumption in Sweden is still low. However, the recent increase in consumption of sustainable and locally produced food in Sweden is driving demand for a versatile, functional pulse‐based ingredient that can be incorporated into different food products. This study assessed different treatments (boiling, roasting, and germination) when preparing flour from domestically grown pulses (yellow pea, gray pea, faba bean, and white bean). Functional properties (water and oil absorption capacity, emulsion and foaming properties, and gelation concentration) of the flours produced following different treatments and their nutrient content (total dietary fiber, total choline, and folate content) were determined. Depending on pulse type, all treatments increased (p < .001) water absorption capacity up to threefold and gelation concentration up to twofold, whereas emulsion activity and foaming capacity decreased by 3%–33% and 5%–19%, respectively, compared with flour made from raw pulses. All treatments also had a significant effect (p < .001) on nutrient content. Total dietary fiber increased (p < .02) by 11%–33%, depending on treatment and pulse type. Boiling decreased (p < .001) total choline and folate content in all pulse flours, by 17%–27% and 15%–32%, respectively. Germination doubled folate content (p < .001) in flour from both pea types compared with flour from the raw peas. In conclusion, treated pulse flours could be useful in food applications such as coating batter, dressings, beverages, or bakery goods, to improve the content of fiber, total choline, and folate.
Career experiences of women in science, technology, engineering, and mathematics fields: A systematic literature review
Authors: Makarem Yasmeen , Wang Jia 
Published: November 2019

AbstractThis article offers a systematic review and synthesis of 28 empirical studies exploring the career experiences of women in science, technology, engineering, and mathematics (STEM) fields. Three central questions guided this review, and findings show that theoretically, women's career experiences are mostly studied from behavioral and organizational perspectives. Methodologically, a balanced approach (both quantitative and qualitative) was adopted in these the studies. The empirical evidence suggests that STEM women's career experiences are largely shaped by their own personal characteristics (motivation, self‐efficacy, and passion) and influenced by their parents, male colleagues, and human resources (HR) practices. Meanwhile, STEM women continue to face a myriad of challenges in a predominantly masculine environment (gendered organizational culture, gender‐based stereotypes, struggle with work‐life balance, and lack of mentors). To cope with these challenges, STEM women in the reviewed studies use three types of strategies—conforming, impression management, and proactivity. Based on our review, we derive implications for theory and practice, as well as an agenda for future research.
Sintering of magnesium‐strontium doped hydroxyapatite nanocrystals: Towards the production of 3D biomimetic bone scaffolds
Authors: Scalera Francesca , Palazzo Barbara , Barca Amilcare , Gervaso Francesca 
Published: November 2019

AbstractThe development of biomimetic scaffolds is a challenging aim in the field of bone repair for fabrication of osteoconductive and osteoinductive scaffolds. Biogenic hydroxyapatite (HA) is not stoichiometric but is substituted by several ions. An approach to improve synthetic scaffolds biomimetism can be the doping with osteoinductive ions. To this aim, herein thermally stable magnesium‐strontium hydroxyapatite (HAMgSr) nanocrystals were synthesized and used for the fabrication of sintered highly porous scaffolds. The chemical and physical properties of the obtained scaffolds were analyzed by X‐ray diffraction, scanning electron microscopy, mechanical testing. Three different substituting ions percentage were analyzed and among these, the copresence of Mg and Sr at 0.5 wt% has shown the best results in terms of thermal stability and mechanical properties. The potential utilization of these materials for bone regeneration purposes was preliminarily evaluated in vitro, by assaying proliferation of viable osteoblast‐like cells; the experimental evidences suggest that the scaffolds can be exploited as bone‐mimicking substrates suitable to support cell growth and proliferation. These observations underline the importance of the presence of Mg and Sr in scaffolds for bone remodeling as well as the good potential of the newly developed scaffolds for clinical use in tissue engineering.
Demographic differences in the utilization of clinical and direct‐to‐consumer genetic testing
Authors: Carroll Nikki M. , Blum‐Barnett Erica , Madrid Sarah D. , Jonas Cabell , Janes Kristen , Alvarado Monica , Bedoy Ruth , Paolino Valerie , Aziz Nazneen , McGlynn Elizabeth A. , Burnett‐Hartman Andrea N. 
Published: November 2019

AbstractGenetic testing has increased over the last decade due to growth in the number of clinical and direct‐to‐consumer (DTC) tests. However, there is uncertainty about how increased DTC genetic testing affects disparities. Between November 2017 and February 2018, a nationwide electronic survey on experiences with genetic testing was conducted among adult Kaiser Permanente members. Logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals comparing receipt of clinical and DTC genetic testing between groups by race and ethnicity. Invitations were sent to 57,331 members, and 10,369 surveys were completed. 22% of respondents had received genetic testing (17% DTC and 5% provider‐ordered). Non‐Hispanic Whites were more likely than other groups to have clinical genetic testing but were similar to Hispanics and non‐Hispanic Blacks in rates of DTC genetic testing. Among those who received any health‐related genetic test, 10% reported abnormal results. Of these, non‐Hispanic Whites were more likely than other racial/ethnic groups to speak to a medical professional about abnormal results. Results suggest that racial/ethnic disparities in the use of clinical genetic services persist. Additional research is needed to identify lessons learned from DTC genetic testing that may increase equity in the use of clinical genetic services.