bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis of lateral buds from Phyllostachys edulis rhizome during germination and early shoot stages
Authors: Shou Yuting , Zhu Yihua , Ding Yulong 
Published: November 2019

Abstract
The vegetative growth is an important stage for plants when they conduct photosynthesis, accumulate and collect all resources needed and prepare for reproduction stage. Bamboo is one of the fastest growing plant species. The rapid growth of Phyllostachys edulis results from the expansion of intercalary meristem at the basal part of nodes, which are differentiated from the apical meristem of rhizome lateral buds. However, little is known about the major signaling pathways and players involved during this rapid development stage of bamboo. To study this question, we adopted the high-throughput sequencing technology and compared the transcriptomes of Moso bamboo rhizome buds in germination stage and late development stage. We found that the development of Moso bamboo rhizome lateral buds was coordinated by multiple pathways, including meristem development, sugar metabolism and phytohormone signaling. Phytohormones have fundamental impacts on the plant development. We found the evidence of several major hormones participating in the development of Moso bamboo rhizome lateral bud. Furthermore, we showed direct evidence that Gibberellic Acids (GA) signaling participated in the Moso bamboo stem elongation. Together, these results expand our knowledge on the Moso bamboo internodes fast growth and provide research basis for further study.
Optimal alternative therapy for metastatic HER2-positive breast cancer progression who previously received trastuzumab-based therapy: a systematic review and network meta-analysis
Authors: Feng Fubin , Zhang Tingting , Yin Fang , Liu Cun , Zhuang Jing , Wang Xue , Qi Lingyu , Tian Jinhui , Sun Changgang 
Published: November 2019

Abstract
Background: Trastuzumab remains the standard protocol recommended for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC). After disease progression, the decision to continue trastuzumab treatment in combination with another type of chemotherapy, or to replace it with another HER2-targeted therapy, has not been conclusive. Methods: We systematically searched databases and extracted data from randomized controlled trials (RCTs) on patients who experienced disease progression after receiving trastuzumab-based therapies. Paired meta-analyses were performed to provide a comparison between patients continuously received trastuzumab-based therapy and those receiving other targeted therapies. Bayesian network meta-analysis was used to synthesize available evidence of direct or indirect comparison. Results: The 10 selected articles that included 3,158 patients were analyzed. The paired meta-analysis showed a 29% (hazard ratio (HR): 0.71; 95% confidence interval (CI): 0.60–0.85) reduction in mortality risk for patients continued receiving trastuzumab-based therapy than those receiving other targeted regimen. Bayesian network meta-analysis suggested that pertuzumab and trastuzumab plus capecitabine (PHC) showed an improvement in the overall survival (OS), with the highest surface under the cumulative ranking (SUCRA) (0.962 (82.3%)). In terms of progression-free survival (PFS) and objective response rate (ORR), trastuzumab emtansine (T-DM1) showed the highest SUCRA (0.949 (73.2%) and 0.997 (98.5%), respectively). Conclusions：Continuing trastuzumab with another type of chemotherapy is a better option for patients who experience disease progression after receiving trastuzumab-based therapy. Patients treated with PHC had the highest OS. Meanwhile, patients treated with T-DM1 showed better PFS and ORR than those treated with other regimens.
Association of the gut microbiota with colorectal cancer in a South Asian cohort of patients
Authors: Sahankumari Pramoda , Gamage Bawantha , Malavige Gathsaurie Neelika 
Published: November 2019

Abstract
Background: As the gut microbiome is thought to play a role in the pathogenesis of colorectal carcinoma (CRC), we sought to investigate the patterns of gut microbiota that associate with CRC in a South Asian cohort of patients with CRC. Methods: The relative abundance of 45 types of gut microbial species were determined in faecal samples of CRC patients (n=24), DM (n=20) and healthy age matched controls (n=44), using a PCR array. Data was analyzed using the specific software for analysis of bacterial DNA quantification. Results: The species Bacteroides fragilis (23.9-fold), Bacteroides thetaiotaomicron (8-fold) and Akkermansia muciniphila (5.9-fold) were several-fold over expressed in patients with CRC compared to healthy individuals, whereas bacterial species of the Phylum Proteobacteria were under expressed. There was no difference in the abundance of these 3 species of bacteria with tumour stage or gender and age of patients. Aeromonas species, Enterococcus faecium and Shigella dysenteriae (Proteobacteria) were over 100-fold over abundant in those with DM compared to healthy individuals. Although 70.83% of those with CRC also had diabetes, marked differences were seen between patients with CRC and those with DM. Conclusions: Patients with CRC and DM harbor a markedly different gut microbiota patterns compared to their healthy counterparts. Similar patterns of gut microbial dysbiosis that associate with CRC and DM appear be seen in South Asian populations, compared to Western countries, despite differences in the diet and ethnicity.
Monastrol Targeted KIF11 Showed Potential Treatment Effective of Small Cell Lung Cancer
Authors: Wang Xinhui , Jiang Shanshan , Zhou Baolin , Liu Zhantao , Liu Ziling 
Published: November 2019

Abstract
Objective: This study is to identify Small Cell Lung Cancer (SCLC) driver genes, annotate enrichment functions and key pathways, and also verify Monastrol therapeutic effect. Methods: The gene expression profiles of GSE40275 and GSE43346 was analyzed to identify the DEGs (Differentially Expressed Genes) between SCLC and the normal tissue. GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-protein interaction) network analysis were conducted to find out the enrichment functions, pathways and hub genes. Moreover, in vitro, MTT assay, colony-forming assay, and the scratch assay were performed to verify the effect of Monastrol. Results: There were common 129 up-regulated and 176 down-regulated DEGs between SCLC samples and normal lung samples. KIF11, NDC80 and PBK were identified as hub genes after PPI network analysis. The q-PCR results showed that genes KIF11, NDC80 and PBK consistently expressed higher in cancer cells than normal cell lines. And in vitro assay showed that Monastrol inhibited SCLC cellular viability, proliferation and migration (P < 0.01). Conclusion: KIF11, NDC80 and PBK were aberrantly expressed and could be potentially applied as diagnostic biomarkers, therapeutic targets and prognostic biomarkers. Monastrol was a promising drug in treatment of SCLC patients. Key words: bioinformatics; lung science; SCLC; Monastrol.
A simple preparation route for polysilicate titanium salt from spent titanium solutions
Authors: Xu Bin , Zhang Yingjie , Li Xue , Yao Yao , Huang Xuesong , Xia Shubiao , Dong Peng 
Published: November 2019

Abstract
Polysilicate titanium salt (PST) is synthesized by using spent titanium solutions and polysilicic acid (PSiA) as raw materials. PSiA could improve the aggregation ability of titanium salt flocculants and also restrain the hydrolysis of Ti4+ to stabilize titanium salts. Meanwhile, replacing titanium salt with spent titanium solutions could reduce the cost of PST and solve the problem of wastewater treatment in the titanium industry, which makes valuable waste regeneration possible. Scanning electron microscopy (SEM) results show the morphology transformation (sheet, spheroid, and sphere) of PST with different Ti/Si molar ratios. The formation process of PST is analyzed by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). This study investigates the effect of Ti/Si molar ratios on PST flocculation performance in humic–kaolin water and actual domestic wastewater treatment. The in situ floc size change of PST is measured by laser particle size analyzer in humic–kaolin water treatment. Additionally, the performance of PST is comprehensively evaluated on flocculation and sedimentation ability, rapid sweep netting ability and stability. In short, the prepared PST in this study is suitable for treating wastewater with high turbidity and chemical oxygen demand (COD) in a wide range of pH values.
Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects
Authors: Lisco Giuseppe , De Tullio Anna , Iacoviello Massimo , Triggiani Vincenzo 
Published: November 2019

Background:
Both the morbidity and mortality rates from congestive heart failure (CHF)
remain elevated despite the medical and non-medical management of the disease, thus suggesting the
existence of residual risk factors such as thyroid dysfunction. Particularly, the 15-30% of patients with
CHF, especially those with severe ventricular dysfunction, display the so-called low T3 syndrome
(LT3S), which seems to negatively affect the cardiovascular prognosis.

Objective:
Only a few clinical trials have been carried out to verify both the safety and the efficacy of
thyroid replacement in the LT3S, aiming to ameliorate the prognosis of CHF, and most of the results
were controversial.

Methods:
Since the aim of the present review was to briefly overview both the indication and contraindication
of triiodothyronine replacement in CHF and LT3S, the authors searched PubMed using the
medical subject headings (MeSH) related to the following terms: “congestive heart failure” and “low
T3 syndrome” or “euthyroid sick syndrome” or “non-thyroidal sick syndrome”. The research study
only focused on the narrative and systematic reviews, randomized clinical trials and meta-analysis
studies which were conducted before June 2019.

Results:
Studies conducted in both animal models and humans provided controversial information
about the effectiveness and safety of the T3 replacement for improving ventricular dysfunction, particularly
in the long-term.

Conclusion:
Further clinical trials are needed to better explore the role of LT3S in patients with CHF
and its consequent therapeutic strategy in this clinical setting.
EXPLORATION OF IN VIVO ANTIOXIDANT ACTIVITY OF 50% ETHANOLIC EXTRACT OF SESAMUM INDICUM L. SEED AGAINST HIGH FAT DIET INDUCED RATS
Authors: KHAN ZAFAR JAVED , KHAN NAEEM AHMAD 
Published: November 2019

Objective: The aim of the present study was to investigate the in vivo antioxidant potential of 50% ethanolic extract of Sesamum indicum against high-fat diet-induced rats.
Methods: Animals were treated with plant extract for 30 d, and a high-fat diet was given to all groups except plain control, throughout, out the study. And alpha-tocopherol acetate (Vit, E) was used as standard. Pre-treatment with 16 mg/100 gm of body weight of 50% ethanolic extract of Sesamum indicum improved the Superoxide dismutase, catalase, glutathione, and lipid peroxidation levels significantly as compared to control group.
Results: The present studies revealed that Sesamum indicum has significant in vivo antioxidant activity and can be used to protect tissue from oxidative stress. The result showed that the activities of SOD, catalase, lipid peroxidase, and glutathione, in the group treated with high-fat diet declined significantly than that of normal group.
Conclusion: 50% ethanolic extract of in the dose of Sesamum indicum 16 mg/100 gm of body weight, has improved the SOD, catalase, glutathione, and lipid peroxidase levels significantly, which were comparable with high-fat-diet-induced rats. Based on this study we conclude that the 50% ethanolic extract of Sesamum indicum possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress.
SYNTHESIS AND BIOLOGICAL EVALUATION OF SPIRO (INDOLE-THIAZOLIDINE) DERIVATIVES AS ANTIMICROBIAL AGENTS
Authors: SHINDE PRIYANKA NIVRUTTI , RASKAR MANISH ASHOK 
Published: November 2019

Objective: The present study aims to synthesize and biological evaluation of Spiro-[Indole-Thiazolidine] derivatives as antimicrobial agents.
Methods: The reaction sequence involves microwave-induced preparation of N-(2-oxo-1,2-dihydro-3’H-indol-3-ylidene)pyridine-4-carbohydrazide [3] from isoniazid [1] and isatin [2] followed by the cyclo condensation of [3] and mercaptoacetic acid under microwave condition to achieve the synthesis of spiro-[indole-thiazolidine] derivatives [4]. The resulting compounds were then allowed to react with various aromatic and heterocyclic aromatic aldehydes to afford arylidene derivatives [5a-l].
Result: Isoniazid (1) on condensation with isatin (2) in the presence of catalytic amount of glacial acetic acid furnished N-(2-oxo-1,2-dihydro-3’H-indol-3-ylidene) pyridine-4-carbohydrazide (3), which showed characteristic IR, absorption bands. Compound (3) underwent Spiro cyclization upon its reaction with mercaptoacetic acid in the presence of anhydrous ZnCl2 to form spiro-[indole-thiazolidine] compound (4). Compound (4) was then condensed with aromatic aldehydes to give arylidene derivatives (5a-l), which were characterized by IR and 1H NMR spectral data.
Conclusion: All the synthesized compounds were screened for antimicrobial activity by the cup plate method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria.
AMELIORATIVE EFFECTS OF STEM BARK OF THE WONDER TREE, PROSOPIS CINERARIA (L.) DRUCE AGAINST LPS-INDUCED TOXICITY: AN IN VITRO STUDY
Authors: SHARMA VEENA , SHARMA PREETI 
Published: November 2019

Objective: The present experimental investigation was planned to unravel and analyze the therapeutic potential of hydro-ethanol extract prepared from the stem bark of Prosopis cineraria against LPS-induced toxicity under in vitro conditions.
Methods: Liver tissue samples from healthy Swiss albino male mice (Mus musculus) were used for the study. Liver homogenate (0.9 ml) was treated with 0.05 mg/ml of LPS along with 0.01 to 0.05 mg/ml of hydro-ethanol plant extract and allowed to incubate at 37˚C. The reactions were terminated at different time points at 0 min, 30 min, 1 h, 2 h, 4 h, 8 h and 24 h and alterations in oxidative stress (LPO, CAT, SOD, GSH, GST, and GPx) and biochemical parameters of hepatic toxicity (AST and ALT, ACP and ALP) were studied.
Results: The results demonstrated that the obliterations in the levels of oxidative and biochemical parameters due to LPS induced toxicity were restored by the treatment with hydro-ethanol extract of Prosopis cineraria under in vitro conditions. The altered levels were biochemical parameters were observed at 0.05 mg/ml LPS concentration after 2 h; but administration of hydro-ethanol plant extract at concentration 0.04 mg/ml effectively reduced its level when compared to LPS treated samples under in vitro conditions
Conclusion: The present research work unravelled the alleviating potential of a hydro-ethanol extract of Prosopis cineraria against LPS-induced toxicity by combating oxidative stress under in vitro environment.
A RANDOMIZED CONTROLLED TRIAL OF CURCUMIN AND DICLOFENAC COMBINATION IN KNEE OSTEOARTHRITIS
Authors: SHEP DHANESHWAR , KHANWELKAR CHITRA , GADE PRAKASHCHANDRA , KARAD SATYANAND 
Published: November 2019

Objective: The objective of the study was to evaluate pain relief and safety of the combination of curcumin and diclofenac versus diclofenac alone in the treatment of knee osteoarthritis (OA).
Methods: 140 patients of knee OA meeting inclusion criteria were randomized to receive either curcumin 500 mg with diclofenac 50 mg twice daily or diclofenac 50 mg tablet al. one twice daily for 28 d. Patients were assessed at baseline, Day 14 and Day 28. Primary efficacy measure was severity of pain (VisualAnalogue Scale) at day 14 and day 28. Safety after treatment was evaluated by recording side effects and laboratory investigations.
Results: Patients receiving curcumin plus diclofenac showed significantly superior improvement in severity of pain at each study visit (p<0.001) when compared to diclofenac. Adverse effects were significantly less in the curcumin plus diclofenac group (p<0.001).
Conclusion: Combination of curcumin and diclofenac showed a significant improvement in pain on the basis of VAS when compared to diclofenac which may be due to the synergistic effect between curcumin and diclofenac
CONHECIMENTOS DOCENTES, FORMAÇÃO INICIAL E COMPONENTES FÍSICO-NATURAIS DO ESPAÇO NA GEOGRAFIA ESCOLAR
Authors: Morais Eliana Marta Barbosa de 
Published: November 2019

O que os professores precisam saber para ensinar? Quais as contribuições da formação inicial em Geografia para a atuação docente? Quais conhecimentos os professores de Geografia têm considerado fáceis ou difíceis de serem ensinados? É com o intuito de refletir sobre esses questionamentos, amparados em teóricos que tem discutido os conhecimentos docentes, que nos propusemos compreender como tem sido encaminhado o ensino dos componentes físico-naturais do espaço na Geografia Escolar. Assentado em metodologia do tipo qualitativa e na realização de questionários com professores de Geografia, que atuam nas redes estaduais e municipais de Goiânia, verificamos a existência de dificuldades no ensino dos componentes físico-naturais do espaço na Educação Básica. Elementos em torno da relação professor aluno, da mediação docente, da abordagem do cotidiano e do trabalho com os conhecimentos didáticos do conteúdo na formação inicial podem qualificar a formação de professores para a sua futura atuação profissional.
Abolishing Domein Verclaring in the Dominating Rights of Common Land in Indonesia
Authors: Rusyad Zahir , Handoko Widhi 
Published: November 2019

The implementation of PP. No. 24 year 1997 on Land Registration along with its derivates are still very close with the domein verklaring, but not all agrarian and spatial experts focus on the assessment of the domein verklaring practice. Land certification arrangement which is Land Registration System (PTSL) is still normative legatlistic. This matter can be read in the Requirement of Complete Land Registration System No. 1 year 2017 about the change of regulation of Agrarian and Affairs Spatial Ministry/Head of BPN RI No. 35 year 2016, on the Acceleration of the implementation of PTSL in Article 12 and so on. Land registration requires formal proof of all land rights objects. This means that indigenous land will not have place in the land registration system. Proof of common land rights can only be done anthropologically rather than normatively legalistic by showing formal letters, such as Letter D and C Desa. The formal requirement on the indigenous land proof creates a new style of domein verklaring. It triggers a lot of agrarian conflicts. Indigenous land conflicts will not be finished unless the verklaring domein ends with a progressive system which not merely based on formal proof. The policy of Ministry Agrarian and Affairs Spatial Planning/Head of BPN RI on One Map Polecy (one land registration map: the village land map & indigenous land) is on the right track but unfortunately technically the policy is not in line with the latest technological developments. The policy should lead to E-Certificate Land and On Line Service of land registration service through the application of Progressive Publicity Stelsel.
Medical, social and organizational bases of staff security in penitentiary institutions of Russia
Authors: Ишков Юрий Владимирович , Ishkov Yuriy Vladimirovich 
Published: November 2019

The article discusses various aspects of ensuring the safety of employees of the penal and correctional system in prisons of the Russian Federation at the present stage of development
of society. Particular attention is paid to the influence of a criminogenic environment on the penal and correctional system staff performing their official duties in pre-trial detention centers and cor-rectional facilities. The regulatory framework governing the procedure and conditions of service by the employees of the Russian penitentiary system has been characterized. Three main objects of security are distinguished: personality (its rights and freedoms), society (its material and spiritual values), state (its constitutional system, sovereignty and territorial value). The shortcomings in the work of the penal and correctional system, which have a negative impact on the safety of personnel of institutions of the Federal Penitentiary Service, have been analyzed. The emphasis is placed on the need to ensure medical safety for prison staff and persons held in prisons
Organization of dental care – caries prophylaxis in children and teenagers in Poland
Authors: Włoch Krzysztof , Książek Piotr , Krajewska Anna , Rolińska Dorota 
Published: November 2019

Abstract
Dental caries in children and teenagers is a social problem and an important element in public health. It stems from its high prevalence and the consequences of not implementing proper treatment are serious. Younger and younger children suffer from dental caries. When it is not treated, the consequences tend to be serious and costly. Pathogenesis of dental caries, methods of treatment and its prevention have been described based on available literature.
The decline in frequency of its appearance will be beneficial for both the sick and society. It will be possible thanks to an early introduction of caries prophylaxis. What is more, a change of mindset and lifestyle is highly recommended as well, not to mention the fact that full and easy access to dental care seems to be essential. All of the factors mentioned above are strictly connected with the proper organization of dental care providing special treatment for children and teenagers in Poland. Its scale should be wide and should cover such activities like teaching to brush one’s teeth properly, access to fluoridation or treatment provided in public dental surgeries located, for example, on school grounds. Current organization of dental care is dealing better and better with the issue concerned, however, to minimalize the risk of caries in children further changes should be introduced.
Metaphorical Descriptions of Well-Doers
Authors: Dryll Ewa Marta 
Published: November 2019

Abstract
What is a metaphoric picture of a “well-doer” made of? In a study devoted to the development of the ability to use metaphorical descriptions of humans, I tried to establish the semantic fields of four target metaphors: Human-Apple Tree, Human-Sun, Human-Cup, Human-Dolphin. Over 300 young adults (the exact number depending on the stimuli), both men and women aged 19-26, were asked to decipher the metaphors’ meanings. The results were obtained mainly by qualitative analysis, with frequency counts of clusters containing synonymous meanings. The results indicate that, while creating imaginary characteristics of ‘“kind humans,” young adults focus on three factors: benefactor provides help (which takes various, but consistent forms: he/she gives hope, an ear to listen to one’s problems, shares fruits of work, provides warmth and joy, etc.), benefactor’s mental stability (as opposed to sudden changes of mood, which is associated with weakness), benefactor’s skill of merging cheerfulness and tranquility. The semantic fields of stimuli addressed to kindness are more complex than the ones connected with evil. Goodness may be associated with wisdom, maturity, generosity, with both inactivity and vividness. Beauty seems to be less important than was expected. The results may serve for developmental comparisons.