bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PENGETAHUAN PENCEMARAN LINGKUNGAN DAN AGAMA DENGAN PERILAKU RAMAH LINGKUNGAN MAHASISWA
Authors: Murniningsih Murniningsih , Norah Siti 
Published: December 2019

Perilaku ramah lingkungan merupakan perilaku dalam meminimalisir dampak negatif terhadap lingkungan. Pengetahuan tentang pencemaran lingkungan dan agama akan membentuk manusia berperilaku ramah terhadap lingkungan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan tentang pencemaran lingkungan dan agama yang berkaitan dengan lingkungan terhadap perilaku ramah lingkungan mahasiswa. Penelitian ini dilakukan di UIN Antasari. Responden berasal dari mahasiswa Prodi Tadris Kimia Angkatan 2017/2018 dan 2018/2019. Sampel merupakan sampel jenuh dengan jumlah responden 20 mahasiswa. Metode yang digunakan adalah metode deskriptif dengan studi korelasional dengan uji hipotesis menggunakan analisis regresi berganda dan korelasi sederhana. Berdasarkan analisis dapat disimpulkan bahwa tidak ada pengaruh yang simultan antara pengetahuan tentang pencemaran lingkungan dan agama terhadap tindakan ramah lingkungan mahasiswa.
A saída de si ao encontro do outro: o discurso religioso do papa Francisco pautado pelo viés etnográfico
Authors: Vieira Vinicius da Silva 
Published: December 2019

O presente artigo tem por objetivo descrever e analisar o discurso do papa Francisco, identificando aspectos do pensamento e da abordagem etnográfica no apelo que o líder religioso faz aos fiéis cristãos(ãs) em prol de uma Igreja em saída. O material de análise é composto de excertos extraídos das exortações apostólicas Evangelii gaudium e Gaudete et exsultate, que descreveremos à luz dos campos dos estudos discursivos de linha francesa, da análise do discurso religioso e da etnografia, sendo esta tomada por nós não só como um método de pesquisa, mas como categoria de pensamento, isto é, como um postulado que rege o lidar de seres humanos com outros seres humanos. Constatamos, no discurso do papa Francisco, significativa presença de traços de um modelo etnográfico reflexivo-performativo (pensamento-prática), que apontam para a experiência de uma Igreja renovada e em permanente saída.
ANALISIS STILISTIKA DAN NILAI PENDIDIKAN KARAKTER DALAM LIRIK-LIRIK LAGU FOURTWNTY ALBUM LELAKU SERTA RELEVANSINYA SEBAGAI BAHAN AJAR BAHASA INDONESIA TINGKAT SMA
Authors: Maretta Arina Dicka , Wardani Nugraheni Eko , Anindyarini Atikah 
Published: December 2019

<p><em>This is descriptive qualitative research using stylistic analysis to describe the existence of language style, diction, image, educational values of the character, and the relevance of the lyrics of Fourtwnty album Lelaku as a teaching material for Indonesian language learning at high school. Data collection techniques use content analysis and interviews. Validity test of data using medhod triangulation techniques and theory. The results of this study indicate</em></p><em>the language style dominated by sinpoke, repetition epizeuksis, and symbolic able to create aesthetic effects, typical, and affirmation; (2) diction is dominated by connotative and typical greetings and names that can create beauty and uniqueness; (3) the image is dominated by vision capable of generating the image of the reader; (4) the values of character education are dominated by religious values, communicative, hard work, and peaceful love that is expected to shape the character of the reader; and (5) The lyrics of Fourtwnty's album Lelaku can be used and developed as learning materials of class X Indonesian language especially poetry appreciation material on basic competence 3.8 and 4.8.</em>
H19/miR-194/E2F3 regulating loop promotes gastric cancer growth and metastasis
Authors: Qin Wanxiang , Shi Ying , Zhu Dan , Chen Yaohua , Li Yuping , Cui Jian 
Published: December 2019

Abstract
Background Gastric cancer (GC) is one of the most frequent malignant digestive tumors and second fatal cancer. This study was to investigate whether lncRNA-H19 can regulate E2F3 expression through competitive binding to microRNA-194 (miR-194), thus regulating GC growth and metastasis. Methods H19, miR-194, and E2F3 expression levels in GC tissues and cell lines were investigated using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR). Meanwhile, the mRNA levels of H19 and E2F3 in gastric cancer tissues were also analyzed through the GEPIA web tool. The binding condition of miR-194 with H19 and E2F3 was investigated using a dual-luciferase reporter gene assay. The regulatory effects of H19 on proliferative, migratory, and invasive abilities of AGS cells and SGC-7901 cells were detected by transwell assay and cell counting kit-8 (CCK-8). Genes involved in proliferation, migration, and invasion (PCNA, Vimentin, and N-cadherin) were determined using QRT-PCR. The regulatory interaction between H19 and miR-194, miR-194, and E2F3 were investigated using rescue experiments. Results The results revealed that H19 was highly expressed in GC tissues and cell lines than those of controls. Downregulated H19 decreased the proliferation, migration, and invasion of AGS cells and SGC-7901 cells. H19 was demonstrated that being the molecular sponge of miR-194 in regulating the growth of the GC cells. The level of E2F3 expression was also found significantly higher in GC tissues and cell lines than those of controls. And then, the mimics of miR-194 inhibited the expression of E2F3 in the GC cells. CCK-8 assay showed decreased proliferative ability induced by miR-194 mimics were reversed by E2F3 overexpression. Transwell assays showed decreased migratory and invasive ability induced by miR-194 mimics were reversed by E2F3 overexpression. Conclusions This study demonstrates that H19 promotes GC growth and metastasis by regulating E2F3 via competitive binding to miRNA-194.
Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis
Authors: Ranjbary Ali Ghorbani , Mehrzad Jalil , Abdollahi Abbas , Hosseinkhani Saman , Tabatabaee Abbas , Dehghani Hesam 
Published: December 2019

Abstract
Background: The incidence of colorectal cancer (CRC) is rising, worldwide, and is attributed to genetics and epigenetic factors. We aimed to evaluate the key clinicodemographical/epidemiological-and molecular impacts on metastatic CRC in CRC patients from a highly populated area in northeastern Iran. Retrospective clinical materials-based cohort design and patients were analyzed with respect to age, sex, colorectum anatomy, metastasis, mortality as well as to expression of molecular markers B3GALNT2, mucin I ( MUC1), P53 and Ki67.
Methods: Patients, 6260 registered CRC with 3829 underwent surgery, from three medical university hospitals in the study area, during 2006-2016, were analyzed for the clinicodemographic aspects of age, sex, stage of CRC, history of smoking, familial/occupational status and post-surgery survival period as well as mRNA/protein expression of B3GALNT2, MUC1, P53 and Ki67. Factors were set to estimate mortality and risk of metastatic CRC.
Results: ~61%, ~33% and ~6% of adenocarcinomatous CRC were located in colon, rectum and rectosigmoid, respectively, of which younger-and older than 50 was mainly in transvers colon-and colorectum, respectively. Post-surgery survival period of metastatic CRC patients was remarkably longer in patients aged > 50 than those < 50 years old, and worse in females than males. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression in metastatic stage III CRC were highly associated with increased metastasis and mortality. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression correlated with increased risk of a progressed CRC state and mortality. The risk to develop metastatic CRC was higher in males, younger, urban residing-and employed individuals, indicative of a plausible non-genetics/epigenetics contribution to CRC.
Conclusions: The role of possible diagnostic biomarkers, B3GALNT2, MUC1 and Ki67, but not P53, in the etiology/early detection of metastatic CRC is promising. Epigenetic contribution to metastatic CRC risk is predominant.
Moderation Effect of Neighborhood Walkability during a Physical Activity Intervention in Overweight and Obese Elderly Subjects with Metabolic Syndrome.
Authors: Fernández Antoni Colom , Mavoa Suzanne , Ruiz Maurici , Wärnberg Julia , Muncunill Josep , Konieczna Jadwiga , Barón-López Francisco Javier , Fitó Montserrat , Salas-Salvadó Jordi , Romaguera Dora 
Published: December 2019

Abstract
Background: An infrequently studied question is how the objective measurement of neighborhood walkability modulates physical activity changes during a physical activity intervention program in older adults. We assessed the influence of objectively assessed neighborhood walkability inside the city limits of Palma de Mallorca on the change in physical activity during the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, a multicenter randomized trial primarily designed to evaluate the long-term impact of an intensive lifestyle intervention on cardiovascular events. Method: The present study involved 228 PREDIMED-Plus senior participants aged between 55 to 75, recruited in Palma de Mallorca (Spain). Overweight/obese adults with the metabolic syndrome were randomized to an intensive weight-loss lifestyle intervention or a control group. A walkability index was calculated within 1 km buffers around each participant’ baseline home address. Physical activity was assessed using the validated REGICOR Short Physical Activity Questionnaire and accelerometer, at baseline and at 2 follow-up visits (six-months and one-year later). Generalised Additive Mixed Models (GAMMs) were fitted to estimate the association between the neighborhood walkability index and changes in physical activity during follow-up in both the intervention and control group. Results: After one-year of intervention, higher neighborhood walkability (1 z-score increment) was positively and significantly associated with moderate-to-vigorous accelerometer assessed physical activity duration, (ß = 3,44; 95% CI = 0.52;6.36 minutes per day). When analyses were stratified by intervention arm, the association was only significant in the intervention group (ß = 6.357; 95% CI = 2.07;10.64 minutes per day) (p for interaction = 0.055). There were no statistically significant associations between neighborhood walkability and self-reported leisure-time physical activity nor brisk walking duration. Conclusions: The results indicate that the walkability of the neighborhood could support a physical activity intervention, helping to maintain or increase older adults’ physical activity.
Gamma-glutamyl transpeptidase is a useful predictor in evaluating the prognosis in pediatric acute liver failure
Authors: Fu Haiyan , Zhao Ruiqin , Bai Gelan , Zhou Hui 
Published: December 2019

Abstract
Background and objective: Pediatric acute liver failure (PALF) progresses rapidly and has a poor prognosis. Therefore, simple, sensitive and specific clinical indicators are needed. Gamma-glutamyl transpeptidase (GGT) plays a role in predicting the prognosis in infantile cholestatic liver diseases. However, its role in predicting the prognosis in PALF remains unclear. Methods: In present study, children with PALF were divided into a normal GGT group and a high GGT group using the GGT level of 50 U/L as the demarcation line. Age, sex, serum total bilirubin, direct bilirubin, albumin, total bile acid, international normalized ratio (INR) and pediatric end-stage liver disease (PELD) score were compared between the 2 groups. In addition, GGT level was subjected to receiver operating characteristic (ROC) curve analysis, and the area under the curve and the optimal diagnostic cutoff value were calculated. Results: A total of 41 children with PALF were enrolled in the study. INR, PELD score and mortality rate were significantly higher in the normal GGT group in comparison to the high GGT group. GGT level had area under the ROC curve of 0.8194 (95% CI : 0.680-0.959); the optimal diagnostic cutoff values were 60 U/L. At the cutoff value, the sensitivity and specificity of GGT level in predicting the prognosis in PALF were 86.36% and 73.68% respectively. Conclusion: GGT exhibited high sensitivity and specificity in predicting the prognosis in PALF. It can be used as one useful prognostic indicator of PALF.
Omega-3 fatty acids in the treatment of acute lung injury: a systematic review and meta-analysis
Authors: Huang Caijie , Zheng Jianming , Huang Wenzhao , Yan Meihao , Hong Liyue , Hong Yuancheng , Jin Runnv , Huang Xincheng , Fan Hongtao , Chen Huizhen , Yang Heping , Su Weiping , Huang Xiaoping 
Published: December 2019

Abstract
Background Several randomized controlled trials (RCTs) have compared the treatment of acute lung injury (ALI) with or without omega-3 fatty acids, yet the results remained inconsistent. Therefore, we attempted this meta-analysis to analyze the role of T Omega-3 fatty acids in the treatment of ALI patients.Methods We searched PubMed et al databases from inception date to Oct 31, 2019 for RCTs that compared the treatment of ALI with or without omega-3 fatty acids. Two authors independently screened the studies and extracted data from the published articles. Summary mean differences (MD) with 95% confidence intervals (CI) were calculated for each outcome by means of fixed- or random-effects model.Results Six RCTs with a total of 277 patients were identified, with 142 with omega-3 fatty acids treatment and 135 without omega-3 fatty acids treatment. Omega-3 fatty acids treatments significantly improve the PaO2 (MD =13.82, 95%CI 8.55– 19.09), PaO2/FiO2 (MD =33.47, 95% CI 24.22– 42.72), total protein (MD =2.02, 95% CI 0.43– 3.62) in ALI patients; furthermore, Omega-3 fatty acids treatments reduced the duration of mechanical ventilation (MD =-1.72, 95% CI -2.84– -0.60) and intensive care unit stay (MD =-1.29, 95% CI -2.14– -0.43) in ALI patients.Conclusions Omega-3 fatty acids can effectively improve the respiratory function and promote the recovery of ALI patients. More studies focused on the long-term efficacy and safety of omega-3 fatty acids use for ALI are needed.
Clinical Features and Management of Endobronchial Hamartoma
Authors: Bian Shuang , Tang Xiaomiao , Wang Jiajia , Zhang Xiaohui , Chen Yanbin , Yang Xinjing , Lei Wei 
Published: December 2019

Abstract
Background: Endobronchial hamartoma(EH) is a benign endobronchial tumor with low incidence. The objective of this study was to explore the clinical features and management of patients with endobronchial hamartoma, improve the diagnosis and treatment.Methods: Retrospective study on the clinical data of 13 cases of endobronchial hamartoma confirmed by pathology in The First Affiliated Hospital of Soochow University from July 2000 to October 2019.Results: The 13 patients, 11 males and 2 females, aged 48-74 years, mean(63±9)years, were diagnosed with EH. Three of the 13 patients with EH are asymptomatic, others had atypical symptoms. CT showed obstructive pneumonia in 10 of the 13 patients. Among the 13 patients, visible endobronchial tumor were present in 7 patients on CT, and only 3 cases were diagnosed with endobronchial tumor by radiologists. All cases received bronchoscopy. Seven patients were treated via flexible bronchoscopy, using electrocautery, argon plasma coagulation(APC) and cryotherapy. Six patients received pulmonary lobectomy via thoracotomy. Follow-up CT scan was performed in 7 of 13 patients(mean 47 months, range 17-69 months), which revealed no recurrence in all 7 patients.Conclusions: In clinical work, EH sometimes may be neglected in CT images. Bronchoscopy plays an important role in diagnosis. Pathological study is required to confirm the diagnosis. The management of endobronchial hamartoma should be individualized, bronchoscopic treatment is the first choice for EH. But in some instances, surgery should be considered.
Cobalamin C deficiency presenting with diffuse alveolar hemorrhage and pulmonary microangiopathy: a case series of four patients
Authors: Liu Jinrong , Tang Xiaolei , Zhou Chunju , Xu Hui , Yang Haiming , Li Huimin , Zhao Shunying 
Published: December 2019

Abstract
Background: The clinical manifestations of combined methylmalonic acidemia (MMA) and homocysteinemia (cobalamin deficiency) vary, but typically include neurologic, developmental and hematologic abnormalities. Only a few patients had diffuse lung disease (DLD). We analyse the clinical features of cobalamin C deficiency (CblC deficiency) who developed late-onset DLD mainly diffuse alveolar hemorrhage (DAH) to strengthen an understanding of it.Results: This study describes 4 patients aged 4-years-2-months to 7-years-6-months with CblC deficiency who developed late-onset DLD. Of these, the first 3 patients presented predominantly with DAH, and the last patient with pulmonary microangiopathy confirmed by lung biopsy. All patients accompanied by pulmonary arterial hypertension (PAH), and 2 accompanied by moderate megaloblastic anemia. Diffuse ground-glass opacification and poorly defined ground-glass centrilobular nodules were seen on high-resolution computed tomography (HRCT) in 1 patient and 3 patients respectively. All patients were suspected of having idiopathic pulmonary hemosiderosis (IPH) or interstitial lung disease (ILD) at other hospitals. The last 2 patients received treatment with high dose corticosteroid before admission, but the symptoms didn’t improve. Moreover, all patients carried compound heterozygous mutations (c.80A>G, c.609G>A) and improved significantly after being treated for CblC deficiency and PAH.Conclusions: CblC deficiency should be considered in the differential diagnosis of DAH especially with PAH, and pulmonary microangiopathy be the main reason of DLD in these patients.
The Association between Platelet count and Liver volume after eradication of Hepatitis C virus by Direct-acting Antivirals: a retrospective study
Authors: Seko Yuya , Moriguchi Michihisa , Takahashi Aya , Okishio Shinya , Kataoka Seita , Okuda Keiichiroh , Mizuno Naoki , Takemura Masashi , Taketani Hiroyoshi , Umemura Atsushi , Nishikawa Taichiro , Yamaguchi Kanji , Itoh Yoshito 
Published: December 2019

Abstract
Background: Although most patients who obtain sustained virological response (SVR) show improved liver function, some patients show decreased platelet counts after eradication of hepatitis C virus (HCV). The aim of this retrospective study was to clarify the association of liver and spleen volumes with platelet count after SVR achieved by direct-acting antiviral (DAA) treatment.Methods: This study enrolled 36 consecutive patients treated by DAAs who obtained SVR between September 2014 and December 2018. Liver and spleen volumes were derived from computed tomography scans obtained at pretreatment, SVR, and 48 weeks after SVR. No patient developed hepatocellular carcinoma during this study. Results: Compared with pretreatment, the median AST, ALT, albumin serum levels, and platelet counts improved significantly at SVR and 48 weeks after SVR. The liver/spleen volumes per body weight were decreased significantly from 22.5/4.2 mL/kg to 21.1/3.6 mL/kg at 48 weeks after SVR. The change in liver volume was associated with change in platelet count, and the change in spleen volume was negatively associated with change in serum albumin level. Multivariate analysis identified change in liver volume (≥95%, odds ratio 76.9, P = 0.005) as the factor associated with improvement in the platelet count at 48 weeks after SVR. The patients with increased liver volume at 48 weeks after SVR showed increased platelet count. Conclusions: Both liver and spleen volume once decreased significantly by eradication of HCV. The patients with re-increased liver volume showed rapid increase of platelet count.
Prevalence Of Fatty Liver Disease And Associated Factors Among Outpatients At Muhas Academic Medical Centre,tanzania
Authors: Simelane Nontobeko Nokulunga , Pallangyo Pédrö P. , Komba Ewaldo V. , Mugusi Ferdinand 
Published: December 2019

Abstract
Background: Fatty liver disease has become an important cause of chronic liver disease and an alarming public health problem. Several studies around the globe have revealed the prevalence of fatty liver disease to range between 10% and 63.5%. In recent times, fatty liver disease has gained global prominence because of its associated increased risk of end-stage liver disease, liver failure and hepatocellular carcinoma. In general, patients with fatty liver disease have increased all-cause mortality and liver-related mortality compared to the general population thus its prevention, diagnosis, and management is crucial in any given population. There is limited information regarding fatty liver disease in a Tanzanian population. Methods: A cross-sectional study conducted from June 2018 to November 2018 at MUHAS Academic Medical Centre – Dar es Salaam, Tanzania. Consenting patients attending internal medicine clinics were interviewed, examined and investigated. Socio-demographic information, clinical, laboratory, and assessment of awareness about fatty liver disease parameters were gathered during the interviews. Fatty liver disease was identified with ultrasound imaging. Continuous variables were compared with the use of student’s t-test and categorical data with the use of chi-squared test. To assess for associated factors, we performed logistic regression analyses, p<0.05 was used to denote significance. Results: A total of 432 outpatients were enrolled. The prevalence of fatty liver disease was 13.9%. Independent associated factors of fatty liver disease were the male gender, having diabetes mellitus, waist circumference >99M/80F, high total cholesterol >220mg/dl, high triglycerides >170mg/dl, and low HDL < 40mg/dl. Conclusion: Fatty liver disease is not uncommon among outpatients in Tanzania. Factors that were associated with fatty liver disease in this current setting were similar to the ones reported in several other settings around the globe. Strategies to improve health education are vital. Early diagnosis and timely management of fatty liver disease will certainly improve the quality of life and its expectancy at large. Key words: Fatty liver disease, NAFLD, Tanzania