bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetic/pharma-codynamic study of pralurbactam (FL058) combined with meropenem in a neutropenic murine thigh infection model
Authors: Huang Zhiwei , Li Wenfang , Zhang Ruohao , Li Yi , Li Xin , Bian Xingchen , Zheng Shansong , Wang Xinmei , Zhang Ning , Gao Cong , Guo Beining , Wang Zhenling , Zhang Jing , Wu Xiaojie 
Published: December 2024

IntroductionPralurbactam (FL058) is a novel β-lactamase inhibitor with good inhibitory activity on class A, C, and D β-lactamases. This study aimed to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) relationship of pralurbactam/meropenem in a neutropenic murine thigh infection model.MethodsAfter 2-h infection, neutropenic mice was treated with meropenem every 2 h alone or in combination with pralurbactam at different dosing frequencies for 24 h, and the colony count in the thighs was determined before and after treatment. The maximum effect model was fit to the PK/PD relationship to determine the PK/PD index and targets for pralurbactam in combination with meropenem resulting in a static effect and 1-log10 kill.ResultsThe plasma drug concentration-time data demonstrated that the PK profiles of pralurbactam were consistent with a one-compartment model. Pralurbactam demonstrated a linear PK profile in mice plasma. The percent time of free drug above 1 mg/L (%fT &gt; 1 mg/L) was the PK/PD index that best described the bacterial killing effect of pralurbactam/meropenem over 24 h. When the PK/PD index %fT &gt; 1 mg/L reached 38.4% and 63.6%, pralurbactam/meropenem combination would achieve bacteriostatic effect and 1-log10 reduction against Klebsiella pneumoniae in thigh bioburden, respectively.ConclusionThese PK/PD data derived from mouse thigh infection models will be used to inform the optimal dosing regimen of pralurbactam/meropenem combination in clinical trials.
Association between telomere length and idiopathic normal pressure hydrocephalus: a Mendelian randomization study
Authors: Yang Feng , Cai Hanlin , Ren Yimeng , Huang Keru , Gao Hui , Qin Linyuan , Wang Ruihan , Chen Yongping , Zhou Liangxue , Zhou Dong , Chen Qin 
Published: December 2024

ObjectiveIdiopathic normal pressure hydrocephalus (iNPH) is highly prevalent among elderly individuals, and there is a strong correlation between telomere length and biological aging. However, there is limited evidence to elucidate the relationship between telomere length and iNPH. This study aimed to investigate the associations between telomere length and iNPH using the Mendelian randomization (MR) method.MethodsThe genetic variants of telomere length were obtained from 472,174 UK Biobank individuals. Summary level data of iNPH were acquired from 218,365 individuals of the FinnGen consortium. Five MR estimation methods, including inverse-variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple mode, were used for causal inference. Comprehensive sensitivity analyses were conducted to test the robustness of the results. In addition, multivariable MR was further implemented to identify potential mechanisms in the causal pathway from telomere length to iNPH.ResultsGenetically determined longer telomere length was significantly associated with decreased risk of iNPH (OR = 0.44, 95% CI 0.24–0.80; p = 0.008). No evident heterogeneity (Cochran Q = 138.11, p = 0.386) and pleiotropy (MR Egger intercept = 0.01, p = 0.514) were observed in the sensitivity analysis. In addition, multivariable MR indicated that the observed association was attenuated after adjustment for several vascular risk factors, including essential hypertension (IVW OR = 0.55, 95% CI 0.30–1.03; p = 0.061), type 2 diabetes (IVW OR = 0.71, 95% CI 0.09–5.39; p = 0.740) and coronary artery disease (IVW OR = 0.58, 95% CI 0.31–1.07; p = 0.082).ConclusionOur MR study revealed a strong negative correlation of telomere length with iNPH. The causal relationship might be driven by several vascular risk factors.
Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes
Authors: Boerwinkle Varina L. , Nowlen Mary A. , Vazquez Jesus E. , Arhin Martin A. , Reuther William R. , Cediel Emilio G. , McCarty Patrick J. , Manjón Iliana , Jubran Jubran H. , Guest Ashley C. , Gillette Kirsten D. , Nowlen Frances M. , Pines Andrew R , Kazemi Meitra H. , Qaqish Bahjat F. 
Published: December 2024

ObjectiveResting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes, per a prior meta-analysis. Our goals were to further characterize this agreement, by broadening the queried rs-fMRI analysis subtypes, comparative modalities, and same-modality comparisons, hypothesizing SOZ-signal strength may overcome this heterogeneity.MethodsPubMed, Embase, Scopus, Web of Science, and Google Scholar between April 2010 and April 2020 via PRISMA guidelines for SOZ-to-established-modalities were screened. Odd ratios measured agreement between SOZ and other modalities. Fixed- and random-effects analyses evaluated heterogeneity of odd ratios, with the former evaluating differences in agreement across modalities and same-modality studies.ResultsIn total, 9,550 of 14,384 were non-duplicative articles and 25 met inclusion criteria. Comparative modalities were EEG 7, surgical outcome 6, intracranial EEG 5, anatomical MRI 4, EEG-fMRI 2, and magnetoencephalography 1. Independent component analysis 9 and seed-based analysis 8 were top rs-fMRI methods. Study-level odds ratio heterogeneity in both the fixed- and random-effects analysis was significant (p &lt; 0.001). Marked cross-modality and same-modality systematic differences in agreement between rs-fMRI and the comparator were present (p = 0.005 and p = 0.002), respectively, with surgical outcomes having higher agreement than EEG (p = 0.002) and iEEG (p = 0.007). The estimated population mean sensitivity and specificity were 0.91 and 0.09, with predicted values across studies ranging from 0.44 to 0.96 and 0.02 to 0.67, respectively.SignificanceWe evaluated centrality and heterogeneity in SOZ agreement between rs-fMRI and comparative modalities using a wider variety of rs-fMRI analyzing subtypes and comparative modalities, compared to prior. Strong evidence for between-study differences in the agreement odds ratio was shown by both the fixed- and the random-effects analyses, attributed to rs-fMRI analysis variability. Agreement with rs-fMRI differed by modality type, with surgical outcomes having higher agreement than EEG and iEEG. Overall, sensitivity was high, but specificity was low, which may be attributed in part to differences between other modalities.
Desmoid-type fibromatosis of the breast in a male patient following cosmetic surgery: a rare case report
Authors: Correa Sandoval Diana Carolina , Gonzalez Reyes Javier , Guajardo Nieto Diego Alberto , Guzman Murguia Jose Luis 
Published: December 2024

BackgroundDesmoid-type fibromatosis of the breast is a rare, benign, but locally aggressive tumor that typically affects women. Its presentation in male patients is exceedingly rare, and even more so following a cosmetic procedure such as liposuction. This case report describes a unique presentation of breast fibromatosis in a male patient, who developed the condition after undergoing liposuction for cosmetic purposes to define the pectoral area. The case highlights the diagnostic challenges it poses due to its malignancy-like appearance on imaging.Materials and methodsA 28-year-old male patient presented with a right palpable mass in the breast following a liposuction procedure aimed at enhancing pectoral definition. Imaging studies, including ultrasound and MRI, raised suspicion of a malignancy. However, histopathological analysis from a core needle biopsy revealed fibromatosis. The patient underwent surgical excision of the tumor, and histological evaluation confirmed the diagnosis of benign desmoid-type breast fibromatosis.ResultsHistopathological examination revealed benign fibromatosis with no evidence of malignancy. The tumor was completely excised with clear margins, and the patient has had no signs of recurrence during the follow-up period.ConclusionsThis case highlights the rare occurrence of breast fibromatosis in a male patient following liposuction for cosmetic purposes. Given its ability to mimic malignancy on imaging, early diagnosis and complete surgical excision are essential for effective management and to prevent recurrence.
Adaptive evaluation of gross total resection rates for endoscopic endonasal approach based on preoperative MRI morphological features of pituitary adenomas
Authors: Shen Ao , Min Yue , Zhou Dongjie , Dai Lirui , Lyu Liang , Zhan Wenyi , Jiang Shu , Zhou Peizhi 
Published: December 2024

ObjectiveThis study aims to define a set of related anatomical landmarks based on preoperative Magnetic Resonance Imaging (MRI) of patients with pituitary adenomas (PAs). It explores the impact of the dynamic relationships between different anatomical landmarks and the tumor on the resection rate and tumor progression/recurrence during the endoscopic endonasal approach (EEA).MethodsA single-center institutional database review was conducted, identifying patients with PAs treated with EEA from December 2018 to January 2023. Clinical data were reviewed, and anatomical landmarks were categorized into two regions: the suprasellar region and the cavernous sinus region. Following basic statistical and univariate logistic regression analyses, patients were randomly divided into training and validation sets. A nomogram was then established through the integration of least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression analysis. The clinical prediction model was evaluated using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis. Kaplan-Meier curves were plotted for survival analysis.ResultsA total of 626 patients with PAs were included in the study, with gross total resection (GTR) achieved in 570 cases (91.05%). Significant differences were observed in the distribution of age, Knosp grade, and tumor size between the GTR and near total resection (NTR) groups. LASSO regression identified 8 key anatomical landmarks. The resulting model demonstrated an AUC of 0.96 in both the training and validation sets. Calibration curves indicated a strong agreement between the nomogram model and actual observations. Survival analysis revealed that the extent of resection (EOR), age, Knosp grade, tumor size, and PAs extending beyond several anatomical landmarks identified were significantly associated with the progression or recurrence of PAs.ConclusionThis study proposes a model for adaptively assessing the resection rate of PAs by delineating relevant anatomical landmarks. The model comprehensively considers instrument manipulation angles, surgical accessibility during EEA procedures, anatomical variations, and the displacement of related anatomical structures in pathological states. This approach can assist neurosurgeons in preoperative planning and developing personalized surgical strategies.
First-line pembrolizumab in patients with advanced non-small cell lung cancer and high PD-L1 expression: real-world data from a Spanish multicenter study
Authors: Piedra Aida , Martínez-Recio Sergio , Hernández Ainhoa , Morán Teresa , Arriola Edurne , Recuero-Borau Jordi , Cobo Manuel , Cordeiro Patricia , Mosquera Joaquín , Fernández Manuel , García-Campelo Rosario , Calles Antonio , Álvarez Rosa , Zapata-García María , Isla Dolores , Callejo Ana , Iranzo Patricia , Serra-López Jorgina , Barba Andrés , Sullivan Ivana , Felip Enriqueta , Majem Margarita 
Published: December 2024

IntroductionPembrolizumab stands as a first-line option for patients with advanced non-small cell lung cancer (NSCLC) and high programmed death-ligand 1 (PD-L1) expression (PD-L1 ≥50%). Several factors such as antibiotic exposure, low body mass index (BMI), certain metastatic location or poor performance status may influence outcomes.MethodsWe conducted a multicenter retrospective analysis in a cohort of patients with advanced high PD-L1 expression NSCLC treated with first-line pembrolizumab in clinical practice. We sought to evaluate clinical outcomes according to several factors.ResultsAmong the 494 included patients, median age was 67.29 years, 77% were male, 54% and 38% were former or current smokers, respectively; 84% had an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-1, and 48% had a BMI of &lt;25. 32% of patients had bone metastases, 32% brain metastases and 16% liver metastases. 35% of patients had exposure to antibiotics (AB), 44% to corticosteroids and 62% to proton pump inhibitors (PPi). With a median follow-up of 14.3 months, the median overall survival (OS) and progression-free survival (PFS) were 15.9m (95% CI 13.1 to 18.8) and 9.9m (95% CI 7.7 to 12.1), and the overall response rate (ORR) was 43%. After univariate analysis, median OS in patients with ECOG-PS 0 vs. 1 vs. 2 was 36.7m vs. 14.8m vs. 2.7m (p&lt;0.001). Median OS in patients who received treatment with corticosteroids vs. patients without exposure was 11.4m vs. 22.3m (p&lt;0.001). After multivariate analysis, corticosteroid exposure (HR 1.41) and ECOG-PS (HR 2.40) maintained a prognostic impact.DiscussionFirst-line pembrolizumab outcomes in advanced high PD-L1 expression NSCLC patients could be negatively influenced by corticosteroid exposure or poor ECOG-PS.
Anti-migraine medications safety during pregnancy in the US
Authors: Bérard A. , Strom S. , Albrecht D. , Kori S. 
Published: December 2024

BackgroundSpecific antimigraine medications (dihydroergotamine (DHE), triptans) have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains.ObjectivesQuantify the risk of prematurity, low birth weight (LBW), major congenital malformations (MCM), and spontaneous abortions (SA) associated with gestational use of DHE or triptans in a privately insured cohort of pregnant women in the US.MethodsWe conducted a cohort study within the US Merative MarketScan Research Database (2011–2021), composed of a nationally representative sample of patients with employer-provided health insurance. Four independent analyses were conducted to assess the risk of 1) prematurity (&lt;37 weeks of gestation), 2) LBW (birth weight &lt;2,500 g), 3) MCM, and 4) clinically detected SA. Exposure was defined dichotomously as use of DHE or triptan during pregnancy. Generalized estimation equations (GEE) were built to quantify the associations taking into account potential confounders including maternal migraine.ResultsOverall, 767,994 pregnant women met eligibility criteria and were included in the analyses on prematurity, LBW, and MCM; 11,121 cases of SA were identified and analyzed. One hundred and eighty-nine (189 (0.02%)) were exposed to DHE (all in the first trimester), and 4,309 (0.56%) to triptans. Adjusting for potential confounders including maternal migraine, DHE was not associated with a statistically significant risk of prematurity (adjusted RR (aRR) 1.17, 95%CI 0.14, 9.74), LBW (aRR 7.76, 95%CI 0.99, 60.83), MCM (aRR 2.27, 95%CI 0.97, 5.29), or SA (aOR 3.19, 95%CI 0.98, 10.38); DHE was associated with an increased risk of septal defects. All estimates showed increased risk but were unstable. Similarly, triptan use was not associated with any of the studied outcomes.Discussions and ConclusionsAfter considering maternal migraine and other potential confounders, DHE (first trimester) and triptan exposure during pregnancy were not statistically significantly associated with an increased risk for prematurity, LBW, MCM, or SA. Findings on septal defects could be due to chance, and need replication.
A implementação do plantão psicológico em um ambulatório de dor crônica: um relato de experiência
Authors: Santiago Lucas Silveira , Mariz Nataly Netchaeva 
Published: December 2024

Introdução: A dor apresenta uma série de mecanismos fisiopatológicos e significados subjacentes e pode variar muito em relação à sua intensidade, qualidade e duração. De acordo com o CID-11, a dor é definida como crônica quando persistente ou recorrente, com duração maior que três meses. Estima-se que a prevalência de dor crônica seja alta, afetando quase um terço da população mundial. Além disso, a literatura aponta que a dor crônica, independentemente do tipo, é um fator de risco importante para o suicídio. O plantão psicológico visa acolher o sujeito em suas urgências e emergências, e pode ser estabelecido em diversos contextos. No entanto, os estudos científicos sobre o plantão psicológico, em especial no contexto hospitalar, são escassos. Objetivo: Relatar a experiência de implementação do plantão psicológico no ambulatório de dor crônica do HU-UFJF e discutir as potencialidades e limites do plantão enquanto modalidade de intervenção psicológica nesse contexto. Relato de Experiência: O presente trabalho consistiu em um estudo descritivo, qualitativo e teve como objetivo apresentar a experiência de implementação do plantão psicológico no ambulatório multiprofissional de dor crônica do HU-UFJF, na cidade de Juiz de Fora, Minas Gerais, entre os meses de julho de 2021 e fevereiro de 2022, durante a pandemia de SARS-CoV-2. Conclusão: O plantão psicológico mostrou-se um importante espaço de formação para o psicólogo residente, sendo também um relevante espaço de atenção psicológica aos sujeitos com dores crônicas em suas crises e urgências subjetivas.
Cirurgia fetal no tratamento da síndrome de transfusão feto-fetal
Authors: Triana Isabella Schneider de Almeida , Almeida Guilherme Nóbrega , Rocha Júlia Braz Pereira da , Lima Larissa Maciel , Modelli Manoel Eugênio dos Santos 
Published: December 2024

A síndrome de transfusão feto-fetal (TTTS) é uma complicação que afeta gestações de gêmeos monocoriônicos. É causada por um desequilíbrio entre os fluxos sanguíneos dos fetos, devido a anastomoses vasculares placentárias. Por apresentar consequências importantes, o diagnóstico e o tratamento são necessários, e de caráter emergencial. Dessa forma, avaliar a eficiência do tratamento cirúrgico, a fotocoagulação a laser fetoscópico (FLP), é necessário para melhorar as taxas de sobrevivência perinatal.
Сравнение возможностей нейронных сетей и метода Шеппарда для прогнозирования наводнений на основе обработки статистических данных
Authors: Карандеев А.А. , Осипов В.П. 
Published: December 2024

Задача прогнозирования того или иного стихийного бедствия и сопутствующих ему проблем является ключевой во многих странах и регионах. Своевременное принятие соответствующих предупредительных мер помогает свести к минимуму повреждения и траты на последующее восстановление инфраструктуры, а также избегать человеческих жертв. Одним из ключевых подходов для решения подобного рода задач является математическое моделирование и анализ временных рядов. В статье рассмотрена задача прогнозирования наводнений в прибрежном городе Туапсе (Краснодарский край, Российской Федерации), при этом за основу для исследований взяты данные, предоставленные МЧС России. Рассмотрены алгоритмы первичной обработки данных для нивелирования помех и их корректировки для последующего анализа и использования. Представлены результаты сравнительного анализа возможностей нейросетевого моделирования, а также метода Шепарда для решения задач прогнозирования наводнений. Рассмотрены преимущества и недостатки каждого из подходов. Приведены результаты численных экспериментов, демонстрирующие особенности применения каждого из подходов, а также сделан ряд выводов на основе полученных данных.
The task of forecasting a particular natural disaster and related problems is a key one in many countries and regions. Since the timely adoption of appropriate preventive measures helps to minimize damage and expenses for the subsequent restoration of infrastructure, as well as to avoid human casualties. One of the key approaches to solving such problems is mathematical modeling and time series analysis. The article considers the problem of flood forecasting in the coastal city of Tuapse (Krasnodar Territory, Russian Federation), while the data provided by the Ministry of Emergency Situations of Russia is taken as the basis for research. Algorithms of primary data processing for noise leveling and their correction for subsequent analysis and use are considered. The results of a comparative analysis of the capabilities of neural network modeling, as well as the Shepard method for solving flood forecasting problems are presented. The advantages and disadvantages of each of the approaches are considered. The results of numerical experiments demonstrating the features of the application of each of the approaches are presented, and a number of conclusions are made based on the data obtained.
Комплексная оценка проектов информационных систем
Authors: Зацаринный А.А. , Ионенков Ю.С. 
Published: December 2024

В статье рассматривается вопрос комплексной оценки проектов информационных систем (ИС). В настоящее время наблюдается интенсивное внедрение информационных систем (ИС) различного назначения. ИС представляют собой сложные системы, разработка которых требует значительных временных и финансовых затрат. В этом плане весьма важным представляется совершенствование методов оценки проектов ИС для принятия аргументированных решений о их дальнейшем проведении. Проведен анализ существующих подходов к оценке проектов ИС. Отмечены особенности применения методов оценки проектов ИС в России и за рубежом. Представлены основные характеристики широко используемых за рубежом методов оценки уровней технологической/производственной/рыночной готовности проекта - TRL/MRL/CRL. Приведены нормативные документы, регламентирующие применение данных методов в России, а также их ключевые преимущества. Предложен ряд направлений работ по адаптации классических методов TRL/MRL/CRL для их эффективного применения в России, в том числе, для создания ИС в интересах государственного управления.
The article deals with the issue of integrated assessment of information systems (IS) projects. Currently, there is an intensive introduction of information systems (IS) for various purposes. IS are complex systems, the development of which requires significant time and financial costs. In this regard, it is very important to improve the methods of evaluating IS projects in order to make reasoned decisions about their further implementation. The analysis of existing approaches to the evaluation of IP projects is carried out. The features of the application of methods for evaluating IP projects in Russia and abroad are noted. The main characteristics of the methods widely used abroad for assessing the levels of technological/production/market readiness of the project - TRL/MRL/CRL - are presented. The normative documents regulating the use of these methods in Russia, as well as their key advantages are given. A number of areas of work on the adaptation of classical TRL/MRL/LRL methods for their effective application in Russia, including for the creation of IP in the interests of public administration, are proposed.