bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polypharmacy, Inappropriate Medication Use, and Drug Interactions in Older Korean Patients with Cancer Receiving First-Line Palliative Chemotherapy
Authors: Hong Soojung , Lee Ju Hyun , Chun Eun Kyeong , Kim Kwang-Il , Kim Jin Won , Kim Se Hyun , Lee Yun-Gyoo , Hwang In Gyu , Kim Jin Young , Koh Su-Jin , Ko Yoon Ho , Shin Seong Hoon , Woo In Sook , Kim Tae-Yong , Baek Ji Yeon , Kim Hyun Jung , Kim Hyo Jung , Lee Myung Ah , Kwon Jung Hye , Hong Yong Sang , Ryoo Hun-Mo , Kim Jee Hyun 
Published: November 2019

AbstractBackgroundPolypharmacy is an important issue in the care of older patients with cancer, as it increases the risk of unfavorable outcomes. We estimated the prevalence of polypharmacy, potentially inappropriate medication (PIM) use, and drug–drug interactions (DDIs) in older patients with cancer in Korea and their associations with clinical outcomes.Subjects, Materials, and MethodsThis was a secondary analysis of a prospective observational study of geriatric patients with cancer undergoing first-line palliative chemotherapy. Eligible patients were older adults (≥70 years) with histologically diagnosed solid cancer who were candidates for first-line palliative chemotherapy. All patients enrolled in this study received a geriatric assessment (GA) at baseline. We reviewed the daily medications taken by patients at the time of GA before starting chemotherapy. PIMs were assessed according to the 2015 Beers criteria, and DDIs were assessed by a clinical pharmacist using Lexi-comp Drug Interactions. We evaluated the association between polypharmacy and clinical outcomes including treatment-related toxicity, and hospitalization using logistic regression and Cox regression analyses.ResultsIn total, 301 patients (median age 75 years; range, 70–93) were enrolled; the most common cancer types were colorectal cancer (28.9%) and lung cancer (24.6%). Mean number of daily medications was 4.7 (±3.1; range, 0–14). The prevalence of polypharmacy (≥5 medications) was 45.2% and that of excessive polypharmacy (≥10 medications) was 8.6%. PIM use was detected in 137 (45.5%) patients. Clinically significant DDIs were detected in 92 (30.6%) patients. Polypharmacy was significantly associated with hospitalization or emergency room (ER) visits (odds ratio: 1.73 [1.18–2.55], p &lt; .01). Neither polypharmacy nor PIM use showed association with treatment-related toxicity.ConclusionPolypharmacy, PIM use, and potential major DDIs were prevalent in Korean geriatric patients with cancer. Polypharmacy was associated with a higher risk of hospitalization or ER visits during the chemotherapy period.
Association Between Obesity, C-Reactive Protein and Serum Total IgE with Skin Prick Test Results in Patients with Allergic Diseases
Authors: İNTEPE Yavuz Selim , YILDIRIM Eylem , ÇÖLGEÇEN Emine , KAPUSUZ GENCER Zeliha , ÇİFTÇİ Bülent 
Published: November 2019

Objective:
To evaluate relationship between skin prick test results and serum total IgE,C-reactive protein,
body mass index in patients with allergic diseases.Material
and methods: This study was conducted in university
hospital between October 2011 and September 2018. Skin Prick test (SPT) was
applied to 433 patients in chest diseases clinic who were referred with
diagnosis of asthma, allergic rhinitis, chronic urticaria and atopic
dermatitis. Also patients’ serum total IgE, C-reactive protein (CRP) levels and
body mass index (BMI) measurements were evaluated.Results:
The study group were consisted of 433 patients, 189 (43.6%) male, and 244[G1]
(56.4%) female. According to the diagnosis, 177 (40.9%) patients had asthma,
108 (24.9%) had allergic rhinitis, 82(18.9%) had atopic dermatitis and 66
(15.2%) had chronic urticaria. SPT was positive in 285 (65.8%) patients while
negative in 148(34.2%). Most frequently seen allergens were the mixture of
trees 23.2%, home dust 19.2%, savage grass 14.8%. Total IgE, CRP, and BMI
values were statistically higher in SPT positive group. (p[G2] ˂0.001).
Obese patients had statistically significant positive skin prick results
(p=0.036). Also, positive total IgE and CRP groups were significantly higher in
positive SPT group (p ˂0.001 and
p=0.008). There was a moderate level and
significant positive correlation between total IgE levels and SPT (r=0.463,
p˂0.001). Also CRP levels (r= 0.128, p=0.008) and obesity (r=0.101, p=0.036) had a low level and
significant positive correlation with SPT. Only total IgE was the statistically
significant risk factor for [G3] the
SPT.[G4]
Positive total IgE level increases the probability of positive SPT by 8.11
times. Conclusion:
This
study suggests that elevated levels of total IgE, CRP and obesity may have
relationship with atopy by increased likelihood of positive skin prick test.
Positive Total IgE level can be a strong predictor for skin prick test
positivity.
Propuesta curricular “Cátedra de la paz” para fortalecer la convivencia
Authors: Betancourt-Rodríguez Milton Andrés , Triana-Rivera Reyes , Torres-Quitora Luis Fernando 
Published: November 2019

Introducción: El presente artículo constituye la propuesta curricular de cátedra de la paz para fortalecer la sana convivencia de los estudiantes, basada en la ley 1732 (2014), que sistematiza y contextualiza la realidad, los objetivos, los principios y los fundamentos metodológicos y didácticos que deben apropiarse en cada institución (P,1). Metodología: Desde el punto de vista metodológico la investigación es de tipo cualitativo, los resultados alcanzados mediante la aplicación encuestas y entrevistas a los estudiantes, docentes que demuestran la importancia de implementar la propuesta curricular de “Cátedra de la Paz” la cual ayuda a la disminución de los conflictos escolares y fortalecer la convivencia entre compañeros. Resultados: En los resultados obtenidos se puede evidenciar que la implementación de la Cátedra de la Paz mediante las actividades y talleres desarrollados y la utilización de la herramienta TIC disminuyeron los conflictos escolares entre los estudiantes. Conclusión: puede concluir que la Cátedra de la paz debe centrarse en la educación como factor primordial para los estudiantes mediante el manejo adecuado de los principios de paz, educación para la paz y los conflictos escolares, así como de las causas y consecuencias que se han identificado en la investigación.
Internet as a Resource of Learning in Increasing Students` Learning Outcomes on Social Studies Subject
Authors: Ginting Febriana Br 
Published: November 2019

This research was conducted based on students’ diverse learning outcomes. To maximize learning outcomes, a supportive learning resource is needed. 8th grader students of Junior High School 12 Bandung have used the internet in social science subject learning. Given the limitations of school facilities and infrastructure, all students access the internet in social science subject learning using personal data connection. The internet is used by teachers and students in finding learning materials and seeking completion of school assignments. The internet helps students to get up to date and relevant learning resources. The method used for collecting the data in this study was through observation, interview, and documentation. The research target was students. The findings of this study indicated that by using the internet, students are easier to find learning material and it helps them to work on school assignments completion, and it helps them to obtain scores that tend to increase. The use of the internet as a learning resource makes students better understand the subject matter, makes it easier to find learning material as well as to find answers for their assignments. However, the barrier to the use of the internet as a source of learning for students was when the learning materials sought are combined with other learning materials.
Étude de l’influence des facteurs du milieu sur la croissance et la production du liège de la suberaie du Parc national de Theniet El Had (Tissemsilt, Algérie)
Authors: Naggar Oumeldjilali , Bouhraoua Rachid Tarik , Torres Enrique , Zedek Mohamed 
Published: November 2019

La variation des capacités de production de liège en relation avec les facteurs du milieu a été évaluée à partir de 53 placettes temporaires installées (763 arbres) dans la forêt montagneuse de chêne-liège du Parc national de Teniet El Had (Algérie). Trois paramètres de production sont retenus : l’épaisseur (mm/an), le rendement d’un arbre moyen (kg) et la productivité d’un peuplement (kg/ha). Le présent travail montre l’effet des principaux facteurs du milieu sur l’épaisseur et la production de liège, identifié à partir de modèles linéaires généralisés. Les résultats ont montré que la croissance du liège est lente (2,8 mm/an) et qu’elle est davantage affectée par des variables propres à l’arbre (état de santé, diamètre et hauteur d’écorçage) que par les sites (exposition). Cependant, le rendement est influencé par les conditions de croissance des arbres, exprimées par leur hauteur totale mais aussi par leur état de santé. À l’échelle des peuplements, deux qualités de sites sont proposées en fonction de la valeur de la hauteur dominante exprimée par le modèle : d’une part, les sites de bonne qualité (Hd > 10 m ; 2 900 kg/ha) caractérisés par des arbres de bonne croissance en largeur et, d’autre part, les sites de mauvaise qualité avec une productivité réduite de plus de moitié (Hd < 10 m ; 1 700 kg/ha). Ces résultats fournissent une orientation de gestion permettant au forestier de planifier la récolte de liège de sa forêt selon la rotation pratiquée et la qualité de la planche recherchée.
Color stability of nanohybrid composite resins in drinks
Authors: Faraoni Juliana Jendiroba , Quero Isabela Barbosa , Schiavuzzo Lívia Semedo , Palma-Dibb Regina Guenka 
Published: November 2019

Aim: The objective of this study was to evaluate the effects of solutions on the color stability of nanohybrid composite resins. Methods: The experimental sample consisted of 90 composite specimens (Beautifil II; Z350XT; Premisa), divided into three subgroups (n=10) according to the solutions (matte tea; lemon flavor isotonic drink; artificial saliva). The specimens were immersed in the solutions (5 mL/specimen) while stirring for 5 minutes, four times a day, with 1-hour intervals, repeated for 15 days. The color of the specimens was analyzed before (baseline) and after the 15th day of cycling using the CIELAB system. Data were analyzed using the two-way analysis of variance (ANOVA) and Tukey’s test (α=5%). Results: Different behaviors were observed among resins. Beautifil II presented the highest color change (∆E=4.18) and less color stability, statistically different from the others (p<.05). The solutions also presented different behaviors. The lemon flavor isotonic drink (∆E=3.95) promoted the highest color change, statistically different from saliva (∆E=2.75; p<.05). The interaction between Beautifil II and isotonic drink became even more evident and significant (p<.05). Conclusion: The isotonic drink is the solution that most affected the resins, and Beautifil II presents the worst color stability.
PENGGUNAAN RESPONSE SURFACE METHODOLOGY PADA OPTIMASI PROSES PENGOLAHAN BAWANG MERAH IRIS IN BRINE
Authors: Ratnaningsih NFN , Vidiantika Desty , Sukasih Ermi , Setyadjit NFN 
Published: November 2019

<p>Bawang merah merupakan komoditas hortikultura yang mudah rusak dan terkadang mengalami kelangkaan di pasaran. Hal ini menimbulkan masalah serius, seperti harga yang fluktuatif dan terjadinya inflasi. Citarasa bawang merah yang khas menyebabkan keberadaannya dipandang penting oleh masyarakat. Untuk mengatasi tidak kontinunya stok bawang merah di pasaran, perlu dilakukan pengolahan minimal proses, seperti pengolahan bawang merah iris in brine. Tujuan penelitian ini adalah untuk menentukan kondisi optimum proses pembuatan bawang merah iris in brine. Optimasi proses dilakukan menggunakan Response Surface Methodology (RSM). Pengolahan data menggunakan Program Design Expert 7.0 dengan tiga faktor, yaitu X1 (konsentrasi garam, %), X2 (konsentrasi asam sitrat, %) dan X3 (lama pemanasan, menit). Hasil optimal diperoleh pada kondisi konsentrasi garam 2,5%, asam sitrat 0,73% dan lama pemanasan 5 menit. Bawang merah iris in brine hasil optimasi memiliki nilai Aw 0,895; nilai chroma 16,97; pH 3,47; total padatan terlarut (TPT) 7,84 ᵒBrix dengan kandungan antosianin 20,21 ppm, kandungan senyawa volatil 91,30 ppm dan aktivitas antioksidan 154,25 ppm.</p><p> </p><p><strong>The use of Response Surface Methodology on optimization of in brine shallot slices production</strong></p><p><br />Shallot is a horticultural commodity that easily damaged and sometimes become scarcity in the market. This triggered serious problems, such as fluctuating prices and inflation. Typical of shallot flavor causes its existences to be considered as important by society. To overcome the uncontinuous stock of shallot in the market, it is necessary to process shallot using minimal processing, such as shallot slices in brine. The objective of this study was to determine the optimum condition of the shallot slices in brine making process. Optimization of the prosess was done using Response Surface Methodology (RSM). Data were processed using Design Expert 7.0, with three factors, namely X1 (salt concentration,%), X2 (citric acid concentration,%) and X3 (duration of heating, minutes). The optimization result was 0.75% citric acid concentration, 2.5% salt concentration and 5 minutes of heating time. The resulting shallot slices in brine has 0.895 of Aw value; 16.97 of Chroma value; 3.47 of pH; 7.84oBrix of total soluble solid (TSS); 20.21 ppm of anthocyanin content; 91.30 ppm of volatile reducing substances (VRS); and 154.25 ppm of antioxidant activity.</p>
Well Abandonment and Subsequent Elimination of Sustained B-Annulus Pressure: A Case Study
Authors: Saikia Partha Protim , Dutta Udai Anand , Gogoi Porag , Maut Partha Protim , Pathak Diganta , Tumung Ranjit , Dutta Hiranya Kumar 
Published: November 2019

Abstract
Maintaining well integrity during well life cycle plays a significant role in the life of a well. Sustained casing pressure (SCP) or Sustained annulus pressure (SAP) in oil and gas wells can result in leakage of the well fluid in undesired regions of the well. Failure to control or manage Annuli pressure may result in uncontrolled release of high-pressure hydrocarbon fluids from formation to the surface thereby leading to significant safety issues and environmental damage.
The Exploratory Well A of Oil India Limited, in the western Block of the Baghjan Structure, was drilled to a measured depth of 4485 m as a J-Bend well and was completed in 4462-m Langpar Sand through perforation in the range 4462.0 m – 4464.0 m in May 2016 after completion with permanent packer. After few days of production testing gradual increase of pressure in the B annulus was observed although there was not any pressure at A- annulus indicating communication behind B annulus casing. Moreover sand, silt, stones and pebbles up to the size of 1.5 cm along with well fluid was observed at the control head. Subsequently, caving level was checked and found at 15 m from surface. Placing adequate well barriers to mitigate sustained annulus pressure became extremely challenging as killing methods viz circulation, bull-heading etc. did not show any encouraging results. CTU operation for wellbore cleaning/ killing was a no-no with available resources for the sizes of stone/pebbles in the bore. Owing to various well integrity issues it was decided to plug and abandon the well, however, with alternate methodology/approach as conventional methods won't yield.
This paper discusses the details of workflow, design, surface arrangement, fluid selection, well control method deployed to subdue the well and subsequent successful abandonment of the well, mitigating sustained annulus pressure issue in a cost effective manner. The abandonment plan was designed on the basis of uncertainties in sub surface well condition, hazard identification, environmental impact and regulatory requirement. This paper also details the different approaches adopted for P&A and step by step plan vis-à-vis actual scenario combined with calculated risks encountered during the execution phase.
As drilling and completion of exploratory wells are expensive, it is critical to identify any well integrity issues and place adequate well barriers in the most-suitable manner to ensure environmental protection as per regulatory requirement. We addressed this, through a customized workflow for design and placement of well barriers eliminating sustain annulus pressure and subsequent successful plug and abandonment using the available cost effective resources.
Challengeable Engineering Design of a Deck for Coiled Tubing Well Abandonment on a Dynamic Positioning Barge
Authors: Bahrami Esmaeil , Seyednia Mahbod , Mosallaie Barzoki Ali Akbar , Zangenehvar Alireza , Rabbani Seyedebrahim 
Published: November 2019

Abstract
Ship collision with offshore platform is one of the rare events in oil and gas industry and generally associates with huge physical and financial damage. An oil tanker collided with a jacket in the South Pars gas field and caused tough conditions for the operator to restore the jacket and wells to their original state. The crucial stages after the accident were killing a perforated well, wreck removal and cutting the wells below the section they had been bent or distorted and finally the wells abandonment by cementing coiled tubing operation on a dynamic positioning barge.
This paper focus on engineering design of a platform for coiled tubing injector head and pressure control equipment on the barge as well as finding a way that coiled tubing string pass through the gap between the platform and the underwater cut point of wells. For this purpose, a deck was proposed to build on the barge having a heavy duty flexible steel pipe extended from the deck to inside the wells cut point.
Various measures should be implemented to design this structure in order to have an operational safe method. The structure had to have sufficient strength to resist the forces applied on it especially during the operation in the predominant weather condition of Persian Gulf in the monsoon season. Therefore, a comprehensive study was conducted to determine stresses applied on the structure subjected to different types of wave velocities using finite element method.
The engineering design and simulation led to construct the proposed deck extending over the port side of the barge and elevating between the main deck and mezzanine deck with a long 4" flexible steel pipe at its bottom. In order to verify the engineering design and simulation before the operation, the structure load tested up to 40 metric tons.
This paper will peer over the challengeable engineering design of the deck for coiled tubing well abandonment under the condition of insufficient offshore facility.
Abandonment Roadmap from Operator's Perspective
Authors: Rusman Liyana , Foong Brian, Hua , Hamid Marklin , Wong Kang Yuon , Maluan Lilihani , Abdussalam Khomeini , Kamis Azman Ahmat 
Published: November 2019

Abstract
Abandonment is becoming a major focus as an operator and also by regulators with a single prominent objective – to reduce its overall operation expenditure. From an operator's perspective, striking balance between abandonment expenditures asset integrity, regulator's requirement and funding for growth projects is key to ensure safe & reliable operations, sustained growth and profatibility.
Sarawak Oil (SK Oil) is a brownfield operator with a huge number of legacy asset; some reaching more than 40 years of age. These assets are constantly being monitored closely for any integrity issue that might emerge due to assets operating beyond their original design life. There is also major development project currently on going which requires huge investments each year. These projects are vital to sustain the positive cash flow for SK Oil operations. Thus, there is a need to diligently balance between the expenditure for growth projects, routine operations and abandonment activities.
In view of the business & operational requirements, a comprehensive abandonment execution outlook, stretching out until the end of field life was developed. The main consideration is the total free cash flow taking into account investments for development projects. The basic formula isOperating Cash Flow minus Capital expenditure where the balance will be used to fund abandonment activities. Another key consideration is the stakeholder management, agreement and consensus have to be met with these partners as well. Thus, the phasing strategy is crucial in determining the prioritization of the candidates which are due for abandonment to ensure minimal cash outflow for a non-cash generating activity.
SK Oil has developed an abandonment roadmap which narrows down to the next five (5) years abandonment outlook. This roadmap has been presented to the regulator and has been agreed upon. Thus, this five (5) years abandonment outlook will be a guiding principle to plan for the actual abandonment execution.
This paper is intended to highlight the approach in developing an abandonment database and key criteria that has been considered to phase out the abandonment activities. This paper is beneficial to operators that manage a huge high number of assets with mostly aging facilities, which need to be abandoned in order to reduce the operating expenditure in the long run.
Lessons Learnt from Ospar and the North Sea: The Importance of Establishing a Regional Decommissioning Agreement in the South China Sea Region
Authors: Tung Aaron , Otto Claus 
Published: November 2019

AbstractThe United Kingdom Continental Shelf (UKCS) is a very mature hydrocarbon basin, and it is currently beginning to experience the full complexity associated with decommissioning. The UKCS region is also subjected to what most would acknowledge is the most developed set of regional arrangements in the shape of Convention for the Protection of the Marine Environment of the North-East Atlantic (OSPAR).Notwithstanding the degree of regional agreement in relation to decommissioning, an emergent insight from the current study in the UKCS is that there are significant issues that remain unresolved, which can be categorized into four main categories: Uncertainties of Regulatory ResponsibilitiesIssues Related to Cross Boundary OperationsIssues Regarding Long Term LiabilityCommercial Issues Across BoundariesThis finding has implications for other parts of the world that will have to face the challenges of decommissioning in the coming years, especially where they have not yet developed regional arrangements. Perhaps most challenging in this last regard will be the South China Sea given its history of contested island and maritime claims among several sovereign states within the region (Buszynski 2012).In comparison with the North Sea, the geographical make-up of the South China Sea is much more complicated and there are many more countries sharing maritime borders in the region, making these potential offshore decommissioning issues more likely to occur. It is thus important for a regional offshore decommissioning agreement to be in placed in the South China Sea region to act both as a guideline and a dispute resolution mechanism in an event that disputes were to occur during offshore decommissioning operations.This paper will highlight the 4 emerging areas of concern (as mentioned above) in offshore decommissioning in the UKCS to suggests that the countries in the South China Sea region could usefully have these in mind as they move to develop regional decommissioning arrangements. Primary qualitative data obtained from the semi-structured interviews will be used in this paper to highlight the concerns on offshore decommissioning in the UKCS while secondary data and literature will be used to link the 2 regions together to demonstrate the need for a consideration of a development of a regional decommissioning agreement in the South China Sea region.