bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Description of Internal and External Factors of Fatigue at Sidoarjo Steel Smelting Company
Authors: Syahfudin Andy Juniar 
Published: February 2020

Introduction: Work fatigue or fatigue is a kind of body prevention from further damages. The fatigue experienced by a worker resulted in a decrease in work performance and lack of body endurance during the work. The workers of steel smelting companies are one of the examples of workers who potentially experience work fatigue. This research aims to ascertain both the internal and external factors of work fatigue experienced by the workers at Sidoarjo steel smelting company. Methods: This research was conducted at Sidoarjo steel smelting company in May 2018 with a population of 30 people. The internal factors in this research are the age, years of service, and nutritional status of the workers. Meanwhile, the external factors are the physical workload, work climate, and noise. This research is descriptive research with observation as the data collection method and is cross-sectional research design. The sample is calculated by applying the total population sampling technique. The data is presented descriptively in the form of frequency, percentage, and cross-tabulation among variables distributions. Result: It is revealed that the majority of the workers, as many as 17 people, undergo mild work fatigue (56.7%). The results of the cross-tabulation show that moderate and severe fatigues are mostly experienced by the workers with these criteria: younger, shorter years of service, obese, fair physical workload, and work climate and noise that exceed the Threshold Limit Value (TLV). Conclusion: It is affirmed that both the internal and external factors are related to work fatigue. Keywords: external factors, internal factors, steel smelting, work fatigue
Factors Related to the Complaints of Musculoskeletal Disorders of Shelving Staff
Authors: Treesyanova Yovian 
Published: February 2020

Introduction: Every worker is exposed to the risk of occupational accidents or occupational diseases when working. Awkward working postures are the postures that cause body parts to detach from its natural postures that can result in the complaints of musculoskeletal disorders (MSDs). This research intends to analyze the factors related to the complaints of MSDs suffered by the shelving staff in the library and reading room in Universitas Airlangga Surabaya. Methods: This research is observational research that applies a cross-sectional design. The sample of this research consists of 27 people chosen by the total population method. The data regarding the individual characteristics and the complaints of MSDs are obtained through interview and filling out a questionnaire that has been standardized. The data on working postures are analyzed by referring to the Rapid Entire Body Assessment (REBA) method, while the data on the complaints of MSDs are scrutinized by implementing the Nordic Body Map (NBM) method. Results: Reveal that most of the shelving staff experience very high-risk level of MSDs (40.7%). Other than that, it is noticed that the working postures consist of squatting (high-risk level), bowing (high-risk level), standing (moderate-risk level), standing with arms stretching (very high-risk level), and standing with arms stretching while tiptoeing (very high-risk level). The collected data is analyzed by using the Spearman correlation test. Conclusion: It can be stated that the strongest factor causing the occurrence of MSDs is the years of service (r=0.803) with a positive relationship, which means that the longer the years of service is, the higher the risk to experience MSDs is. Keywords: complaints of musculoskeletal disorders, individual factors, shelving staff
Mental health of disabled children: a preventive aspect
Authors: Kupriyanova I. E. , Dashieva B. A. , Karaush I. S. 
Published: February 2020

The aimis to identify the priority directions for preventing mental disorders in disabled children following a comprehensive analysis of clinical, social, psychological, ethnic and cultural characteristics over 2009– 2017.Materials and methods. 2,204 people were included in the study: disabled children, students of remedial schools aged 7–18 years old (n = 834); parents of disabled children (n = 772); teachers working in various educational facilities (n = 217); respondents of the survey identifying people’s attitude towards children with disabilities (schoolchildren, students, adults, n = 381). Clinical, psychological and statistical methods were used in the study. To identify depression and anxiety in children, Children’s Depression Inventory (CDI), Childhood Myositis Assessment Scale (CMAS), PedsQL inventory, survey on coping strategies (E. Heim) and adapted questionnaires for suicidal risk and alexithymia were used. For adult participants, the Quality of Life Scale, Hamilton Anxiety Rating Scale, Hospital Anxiety and Depression Scale (HADS), and a questionnaire identifying the attitude towards children with disabilities were applied.Results. A high prevalence of mental disorders in children with disabilities (62.7–95.2%) was identified, and the levels of anxiety, suicidal risk, alexithymia were determined. Children’s families were characterized by impaired structure (50%), parenting styles resulting in pathologies (71.5%), low income level (60%), low qualifications of parents and unemployment (13%), alcohol abuse (17.6%), victimized attitudes and low satisfaction with the psychological criteria of quality of life, combined with low level of anxiety. For teachers, the levels of anxiety and depression and signs of burnout were revealed, and the features of their interaction with disabled children in the educational process were described. The attitude of different social groups to children with disabilities was studied. The methodological conditions for carrying out research and organizing medical and psychological care were formulated.Conclusion. Prevention of mental disorders in disabled children includes identification of early signs of anxiety, depression, suicidal risk and assessment of the quality of life and work. This is ensured by a reasonable choice of research methods, psychosocial rehabilitation with involvement of beloved people, and increase in the tolerance level towards children with disabilities in the society.
Preoperative anemia and hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery
Authors: Author) long feng(Former Corresponding , Xu Longhe , Yuan Weixiu , Xu Zhipeng , Author) ZeGuo Feng(New Corresponding , Zhang Hong 
Published: February 2020

Abstract
Aim This study was designed to explore the prevalence condition and risk factors of preoperative deep venous thromboembolism (DVT) in Chinese elderly with hip fracture. Methods From January 1, 2012, to December 31, 2018, 273 elderly over 70 years old with elective hip surgery were collected from the electronic medical records. Collected Data included demographic characteristics, comorbidities, ASA classification, types of surgeries, types of anesthesia, operation time, fracture to operation time, perioperative blood transfusion, preoperative hemoglobin level, anemia, blood-gas analysis, cardiac function, electrocardiograph, lower limb venous ultrasonography and hospitalization time. Results In all patients, 15 patients (5.6%) had ultrasonography evidence of DVT in affected limbs before surgery. Three of all patients received an temporary inferior vena cave filter placement. Fracture to surgery time, preoperative hemoglobin level, anemia, pulmonary disease and hospitalization time were statistically different between DVT group and non-DVT group (P<0.05 for all). Moreover, preoperative anemia (OR: 0.144, 95%CI: 0.026-0.799, P=0.027) and hospitalization time (OR: 1.135; 95%CI: 1.023-1.259, P=0.017) were the two independent risk factors for preoperative DVT. Conclusion Preoperative anemia and hospitalization time were independent risk factors for venous DVT in Chinese elderly with hip fracture.
Management and Prognostic Prediction of appendiceal mucinous adenocarcinoma with peritoneal metastasis: a single center study in China
Authors: Ma Ruiqing , Wang Bing , Zhai Xichao , Lu Yiyan , Xu Hongbin 
Published: February 2020

Abstract
Background To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors. Methods A retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation and comparison were respectively performed with the Kaplan-Meier method and the log-rank test. The Cox proportional hazards regression method was used for multivariate survival analyses. Results Cytoreduction for appendiceal mucinous adenocarcinoma was conducted on 50 patients (24 males and 26 females), with a median age of 52.5 years at the time of surgery (range 31-71 years). The median overall survival (OS) time was 24 months, with 2-,3- and 5-year survival rates of 53%, 24% and 8%, respectively. At the last follow-up in December 2018, 13 patients were still alive. Multivariate analysis revealed that patients who had low Ki-67 expression (less than 50%) and CCR (completeness of cytoreduction) 0/1/2 score had significantly better OS rate than their respective counterparts. Conclusions Ki-67 expression statue and CCR score could be employed as the prognosis prediction in patients with appendiceal mucinous adenocarcinoma.
Astrocyte-like glia-specific gene deathstar is crucial for normal development, adult locomotion and lifespan of male Drosophila
Authors: Najafi Hadi , Wong Kyle , Kim Woo Jae 
Published: February 2020

Abstract
Background Drosophila melanogaster is a proper model organism for studying the development and function of the nervous system. The Drosophila nervous system consists of distinct cell types with significant homologies to various cell types of more advanced organisms, including human. Among all cell types of the nervous system, astrocyte-like glia (ALG) have conserved functions to mammals and are essential for normal physiology and behaviours of the fly. Results In this study, we exploited the gene expression profile of single cells in Drosophila optic lobe to identify the genes with specific expression pattern in each cell type. Through a bioinformatical analysis of the data, a novel ALG-specific gene (here assigned as deathstar ) was identified. Immunostaining of deathstar in the central nervous system (CNS) showed its presence in specific regions of Drosophila ventral nerve cord, which previously has been characterized as ALG cells. Consistent with the bioinformatical analysis, deathstar -related signals were overlapped with the signals of the previously-reported ALG marker, Eaat1 , supporting its specific expression in ALG cells. At the physiological level, RNAi-mediated suppression of deathstar gene impeded the normal development of male flies without any effects on females. Cell type-specific expression of deathstar RNAi showed that deathstar gene affects locomotion behaviour and lifespan of D. melanogaster , in an ALG-specific manner. Conclusions Taken together, we showed that bioinformatical analysis of a previously reported expression data of Drosophila optic lobe successfully predicted the ALG-specific expression pattern of deathstar gene. Moreover, it was consistent with the ALG-specific effects of this gene on locomotion and lifespan of D. melanogaster, in vivo .
Retrospective analysis of salvage surgery for local progression of brain metastasis previously treated with stereotactic irradiation: diagnostic contribution, functional outcome, and prognostic factors
Authors: Mitsuya Koichi , Nakasu Yoko , Deguchi Shoichi , Oishi Takuma , Sugino Takashi , Yasui Kazuaki , Ogawa Hirofumi , Onoe Tsuyoshi , Asakura Hirofumi , Harada Hideyuki , Hayashi Nakamasa 
Published: February 2020

Abstract
Background: Stereotactic irradiation (STI) is a primary treatment for patients with newly diagnosed brain metastases. Some of these patients experience local progression, which is difficult to differentiate from radiation necrosis, and difficult to treat. So far, just a few studies have clarified the prognosis and effectiveness of salvage surgery after STI. We evaluated the diagnostic value and improvement of functional outcomes after salvage surgery. Based on these results, we reconsidered surgical indication for patients with local progression after STI.

Methods: We evaluated patients with brain metastases treated with salvage surgery for local progression from October 2002 to July 2019. These patients had undergone salvage surgery based on magnetic resonance imaging findings and/or clinical evidence of post-STI local progression and stable systemic disease. We employed two prospective strategies according to the eloquency of the lesions. Lesions in non-eloquent areas had been resected completely with a safety margin, utilizing a fence-post method; while lesions in eloquent areas had been treated with minimal resection and postoperative STI. Kaplan-Meier curves were used for the assessment of overall survival. Prognostic factors for survival were analyzed.

Results: Fifty-four salvage surgeries had been performed on 48 patients. The median age of patients was 63.5 years (range 36-79). The median interval from STI to surgery was 12 months. The median overall survival was 20.2 months from salvage surgery and 37.5 months from initial STI. Primary cancers were lung 31, breast 9, and others 8. Local recurrence developed in 13 of 54 lesions (24%). Leptomeningeal dissemination occurred after surgery in 3 patients (5.6%). Primary breast cancer (breast vs. lung: HR: 0.17), (breast vs. others: HR: 0.08) and RPA class 1-2 (RPA 1 vs. 3, HR:0.13), (RPA 2 vs 3, HR:0.4) were identified as good prognostic factors for overall survival (OS) in multivariate analyses. The peripheral neutrophil-to-lymphocyte ratio (NLR) of ≤3.65 predicted significantly longer OS (median 25.5 months) than an NLR >3.65 (median 8 months).

Conclusion: We insist that salvage surgery leads to rapid improvement of neurological function and clarity of histological diagnosis. Salvage surgery is recommended for large lesions especially with surrounding edema either in eloquent or non-eloquent areas.
Microbial and inflammatory parameters during the process of non-surgical treatment of Peri-implantitis: Topical minocycline application
Authors: Shwe Yee Mon , Inoue Kensuke , Yamamoto Maiko , Hidemi Nakata , Kuroda Shinji , Kasugai Shohei 
Published: February 2020

Abstract
The authors have withdrawn this preprint from Research Square.
Effect of the Polaris Loop ureteral stent on vesicoureteral reflux and relief of lumbago symptoms: a single-center study
Authors: Yan Wei , Qiao Ludong , Du Zhen , Guan Di , Ping Hao , Chen Shan 
Published: February 2020

Abstract
Objective

To verify the effect of the Polaris Loop ureteral stent on vesicoureteral reflux and relief of lumbago symptoms in patients after ureteroscopic procedures.

Methods

This was a prospective single-center analysis of 20 patients who received indwelling bilateral ureteral stents after undergoing ureteroscopic lithotripsy. The Polaris Loop stent and Polaris Ultra stent (both F6 and 26 cm) were implanted randomly on the left and right sides of a patient. The results of the visual analogue scale (VAS) of the symptoms of lumbar discomfort that occurred within 2 weeks after surgery and whether or not vesicoureteral reflux occurred during postoperative cystography were recorded.

Results

The differences between the VAS scores and rates of vesicoureteral reflux for the 2 types of stents were significant (p<0.05). The patients receiving the Polaris Loop stent had lower VAS scores and lower rates of vesicoureteral reflux than the patients receiving the Polaris Ultra stent.

Conclusions

The Polaris Loop stent led to improved patient comfort after ureteroscopy and prevented vesicoureteral reflux of urine. However, careful selection of the appropriate length of stent and appropriate placement technique is required.
Engaging Stakeholders in the Adaptation of the Connect for Health Pediatric Weight Management Program for National Implementation
Authors: Simione Meg , Frost Holly M. , Cournoyer Rachel , Mini Fernanda Neri , Cassidy Jackie , Craddock Cassie , Moreland Jennifer , Wallace Jessica , Metlay Joshua , Kistin Caroline J. , Sease Kerry , Hambidge Simon J. , Taveras Elsie M. 
Published: February 2020

Abstract
Background: Connect for Health is an evidence-based weight management program with clinical- and family-facing components for delivery in pediatric primary care for families of children ages 2 to 12 years. We used the Consolidated Framework for Implementation Research (CFIR) to guide formative work prior to national implementation. The purpose of this study was to describe the process and results of stakeholder engagement and program adaptation.Methods: We used mixed qualitative and quantitative methods to iteratively adapt and optimize the program by assessing needs and perspectives of clinicians and parents, as well as contextual barriers, facilitators and organizational readiness for the uptake of the proposed program tools and implementation strategies. We conducted interviews with primary care clinicians from four health care organizations in Boston, MA, Denver, CO, and Greenville, SC and used principles of immersion-crystallization for qualitative analyses. We also conducted surveys of parents of children with a body mass index ≥ 85th percentile.Results: We reached thematic saturation after 52 clinician interviews. Emergent themes representing the CFIR domains of intervention characteristics, outer and inner setting, and process included: (1) importance of evidence-based clinical decision support tools that integrate into the workflow and do not extend visit time; (2) developing resources that respond to family’s needs; (3) using multimodal delivery options for family resources; (4) addressing childhood obesity while balancing competing demands; (5) emphasizing patient care rather than documentation and establishing sustainability plans; and (6) offering multiple training methods that incorporate performance feedback. Of the parents surveyed (n=400), approximately 50% were Spanish-speaking and over 75% reported an annual income < $50,000. Parents affirmed the importance of addressing weight management during well-child visits, being provided with referrals and resources, and offering multiple methods for resource delivery. Decisions about program modifications were made at the program and healthcare-system level and based on stakeholder engagement findings. Modifications included cultural, geographic, and target audience adaptations, as well as varied resource delivery options.Conclusions: To ensure the fit between the Connect for Health program and national implementation settings, adaptations were systematically made through engagement of clinician and parent stakeholders to support adoption, sustainability, and health outcomes.
Clinical difference between acute appendicitis and acute right-sided colonic diverticulitis
Authors: Song Ji Ho , Lee Sanghun , Ho Han , Seo Jun Seok , Lee Jeong Hun , Lee Seung Chul , Kim Yong Won 
Published: February 2020

Abstract
Background: The clinical presentations of acute appendicitis (AA) and acute right-sided colonic diverticulitis (ARCD) are similar, but the usual treatment for each disease differs between surgical and conservative management. This study aimed to identify the clinical differences between AA and ARCD.Method: We performed a single-center retrospective case-control study on adult patients with AA and ARCD confirmed by computed tomography who had visited an emergency department between March 2018 and February 2019. The clinical variables, including past medical history, presented symptoms and signs, and laboratory findings were compared between the two groups. We subsequently performed a logistic regression analysis for differentiating ARCD from AA based on the results of univariate analyses.Results: A total of 222 (79%) and 59 (21%) patients were enrolled in the AA and ARSD groups, respectively. Logistic regression analysis revealed that factors associated with ARCD were a past history of diverticulitis [OR 141.691 (95% CI: 12.222 – 1642.601), p < 0.001], ketonuria [OR 0.268 (95% CI: 0.099 – 0.726), p = 0.010], anorexia [OR 0.037 (95% CI: 0.007 – 0.207), p < 0.001], and neutrophilia [OR 0.179 (95% CI: 0.062 – 0.519), p = 0.002].Conclusion: Anorexia, neutrophilia, and ketonuria were predictors of AA and a history of diverticulitis was a predictor of ARCD.
Elevated Plasmodium infection and multiple insecticide resistance in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the airport of Yaoundé, the Capital city of Cameroon
Authors: Nongley Nkemngo Francis , Mbugulize Jean Leon Mugenzi , Terence Ebai , Niang Abdoulaye , Wondji Murielle , Tchoupo Micareme , Nguete Daniel Nguiffo , Tchapga Williams , Irving Helen , Ghogomu Stephen M. , Ndo Cyrille , Consortium COMAL , Borrmann Steffen , Wondji Charles S. 
Published: February 2020

Abstract
Background Reducing the burden of malaria requires better understanding of vector populations particularly in forested regions where the incidence remains elevated. Here, we characterized malaria vectors in a locality near the international airport of Yaoundé, the capital city of Cameroon, including species composition, abundance, Plasmodium infection rate; insecticide resistance profiles and underlying resistance mechanisms. Methods Blood-fed adult mosquitoes resting indoors were aspirated from houses in April 2019 at Elende, a village located 2km from the Yaoundé-Nsimalen airport. Female mosquitoes were forced to lay eggs to generate F 1 adult progeny. WHO bioassays were performed to assess resistance profile to insecticides. The threshold of insecticide susceptibility was fixed above 98% mortality rate and mortality rates below 90% were considered indicative of confirmed insecticide resistance according to the WHO test procedures for insecticide resistance monitoring. Furthermore, the molecular basis of resistance and Plasmodium infection rates were investigated.Results Anopheles funestus s.s. was most abundant species in Elende (85%) followed by Anopheles gambiae s.s. (15%) with both having a similar sporozoite infection rate. Both species exhibited high levels of resistance to pyrethroids (<40% mortality). An. gambiae s.s. was also resistant to DDT (9.9% mortality) and bendiocarb (54% mortality) while susceptible to organophosphate. An. funestus s.s. was resistant to dieldrin (1% mortality), DDT (86% mortality) but susceptible to carbamates and organophosphates. The DDT/pyrethroid L119F-GSTe2 resistance allele (8%) and G119S ace -1 resistance allele (15%) were detected in An. funestus s.s. and An. gambiae s.s. respectively. Furthermore, the high pyrethroid/DDT resistances in An. gambiae s.s. corresponded with an increase frequency of 1014F kdr allele (95%). The CYP6P9a P450 resistance allele was absent in the An. funestus s.s. population meanwhile transcriptional profiling of candidate cytochrome P450 genes reveals the over-expression of CYP6P5 , CYP6P9a and CYP6P9b. Conclusion The resistance to multiple insecticide classes observed in these vector populations alongside the high Plasmodium infection rate highlights the challenges that public health vector control programs encounter in sustaining the regular effectiveness of contemporary insecticide-based control interventions in forested areas. More particularly, the resistance observed against the carbamates and possible resistance against the organophosphates constitutes a major concern for IRS.