bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on fault identification of gearbox bearing based on quantum theory
Authors: Wu Congbing 
Published: July 2020

Abstract
In view of the problem that the fault signal of bearing in automobile gearbox is easy to be covered by background noise, a fault signal recognition method based on quantum theory is proposed. This method will quantize the individual sampling signal, and take the vibration signal as the state superposition of fault signal and background noise, deeply study the randomness and local characteristics of sampling signal, and analyze the core information of sampling point, so that the amplitude characteristics of sampling point signal can be converted into the probability distribution of fault signal and noise signal in quantum domain, and change integrated attenuation of noise reduction for the fault signal, and realize the fine quantization noise as well as the highlight of the fault information. Experimental results show that the algorithm is feasible and efficient.
Internal Flow Field Analysis of Three-way Regulating Valve Based on CFD Technology
Authors: Hou Yingzhe , Wu Hao , Li Zhong 
Published: July 2020

Abstract
According to the requirement of low energy consumption and high efficiency of a three-way regulating valve used in a system, based on the CFD software of fluid mechanics, the internal flow performance of the three-way regulating valve was simulated and studied in three dimensions, and the flow field information such as internal pressure and flow velocity of the valve were obtained. The results show that with the increase of the opening degree, the pressure gradient and velocity gradient at the upper valve seat gradually tend to be obvious, the pressure drop at the valve seat and the maximum flow velocity at the sealing surface gradually tend to be extreme, while the change rule at the lower valve seat is opposite. When the valve works under extremely small and extremely large opening conditions for a long time, it will be beneficial to protect the valve.
Determinants of Health and Safety Management in Construction Industry; the Case of Hengyang City, China
Authors: Ashebir Gelaw , Nie Chunlong , Chen Ya , Yirsaw E. 
Published: July 2020

Abstract
The construction industry promotes the development of national social economy and provides necessary infrastructure and enhanced facilities for social comfort. However, it is the most hazardous industries due to high occupational risks and unsatisfactory state of occupational health and safety. This study ascertains and evaluates the factors affecting health and safety management in the construction industries in area undergoing fast infrastructure development, Hengyang city. Two categories of construction industry were chosen for the quantitative study for which stratified sampling procedure was applied and simple random sampling was further used to select the key project participants from the various professional groups. In addition to the actual on-site observation questionnaires and interviews, the interviewees, opinions can also be derived. Statistical technique Relative Importance Index (RII) and Microsoft excel software are used to analyze the data, while the Kendall’s coefficient of concordance is used as a measure of agreement of ranking among factors affecting health and safety management. The analysis shows that the RII and the rank of factors affecting health and safety management in construction industry are vary with in the company categories. Health and safety policy, work environment, and health and safety inspection were ranked as the first three important factors affecting health and safety management in construction sites, respectively. Therefore, relevant stakeholders need to consider the establishment of a valuable management system based on local conditions to provide a strong guarantee for the health and safety of workers and sustainability maintenance of construction projects. This study will inspire future works to be done on the role of owners and the development of further guidelines to lessen the accidents in construction sites.
Study on Soft Foundation Load of Right Line of Double Truss Tunnel
Authors: Guo Rui , Cao Feng , Chen XiaoMing , Ji WeiDong , Men GuangYu 
Published: July 2020

Abstract
According to the load line structure example, the vertical support force of the initial support structure of the tunnel construction section is analyzed based on the load structure method. The calculation results and analysis show that the arch foundation load is scientific and effective. The calculation is for the control of the bearing capacity of the shallow-buried tunnel excavation foundation, and it has important engineering guiding significance to effectively prevent the large deformation of the tunnel section and the surface subsidence.
Modeling the printability of photocuring and strength adjustable hydrogel bioink during projection-based 3D bioprinting
Authors: Sun Yuan , Yu Kang , Nie Jing , Sun Miao , Fu Jianzhong , Wang Huiming , He Yong 
Published: July 2020

Abstract
As a projection based three-dimensional printing method, digital light processing bioprinting (DLPBP) has higher printing resolution and is suitable for constructing finer structures to mimic tissues when compared to extrusion based bioprinting. However, there is a lack of understanding about printing behavior during DLPBP. Herein, a photo crosslinking theory for ink was established and a specified amount of light absorber was added to control crosslinking depth. Then, a standardized methodology was established to quantitatively evaluate printing resolution using different parameters. Complex biostructures, such as the ear, hand, and heart, were precisely printed after understanding the mechanism. Additionally, the mechanical properties of printed samples were accurately adjusted by changing the hydrogel concentration, as well as the degree of substitution and photocrosslinking time. The tissue types printed were from ultra-soft tissues, such as liver (6–8 kPa) to soft tissue, such as the skin (0.3–0.4 MPa). A branching vessel with cells in a real tensile modulus was printed as a demonstration. After 1 week of culture, proliferation and function of human umbilical vein endothelial cells were characterized. Overall, we made it possible to print a mimic complex tissue with high precision, required physical properties and functionalized living cells.
Parameters setup for first-principles on well-formedness and thermodynamic properties of bulk and habit surfaces of Mg2Si
Authors: Liu Tongyu , Ren Yuyan , Pan Ying , Li Yingmin , Liu Weihua 
Published: July 2020

Abstract
The well-formedness, thermodynamic properties and mechanical properties of Mg2Si bulk and Mg2Si (1 0 0), (1 1 0) and (1 1 1) surfaces were calculated by using first-principles based on density functional theory (DFT). Some accurate and efficient parameters were programed by computing massively and repeatedly. The accurate and efficient parameters used in Mg2Si bulk is Energy cutoff (500 eV), k-point (5 × 5 × 5) and exchange-correlation interaction (PBEsol). The relaxation of surficial atoms shows that the rule or rate of expansion and shrink are similar from the second column. The rate of the innermost layer decreases gradually with increasing slab thickness. The rate of the innermost layer in Mg-terminated or Si-terminated Mg2Si (1 0 0) and (1 1 0) is no more than 0.1% when convergent layers are no less than 11. The convergent layers of Mg2-terminated and Si-terminated Mg2Si (1 1 1) are 14 and 16, respectively. The Mg1-terminated Mg2Si (1 1 1) surfaces hardly converge even if the layers reach to 18. Si-terminated surfaces are harder to keep stability than Mg-terminated surfaces in Mg2Si (1 0 0) and (1 1 1) surfaces because of a higher surface energy. Mg2Si (1 1 0) surface energy is a constant because of the nonpolar and stoichiometric Mg-Si terminated surface. Si-terminated and Mg-terminated Mg2Si (1 0 0) surfaces are more stable than Si-terminated and Mg2-terminated Mg2Si (1 1 1) surfaces, respectively. Mg1-terminated Mg2Si (1 1 1) surface is the most stable surface over the entire surfaces in Mg2Si.
Tarsal-Fixation With Aponeurotic Flap Linkage in Blepharoplasty: Bridge Technique
Authors: Jin Rui , Shen Yirui , Yu Wenjie , Xia Ying , Yuan Zhaoqi , Ding Feixue , Lu Lin , Liu Fei , Sun Di , Yang Jun 
Published: July 2020

Abstract

Background
Double eyelid blepharoplasty is the most popular cosmetic surgery among Asian populations. Although various surgical procedures have been reported, certain complications still arise, including asymmetry or the disappearance of the double eyelid crease, an unnatural double eyelid crease curve, and distinct scars.

Objectives
The aim of this study was to describe a new blepharoplasty technique intended to reduce the various complications and create dynamic, natural-looking double eyelids.

Methods
From September 2018 to June 2019, the new technique was performed on 92 Chinese patients. The core of our technique was to construct a reliable motion transmitter, the orbital septum-levator aponeurosis flap, which was sutured to the tarsus. The outcomes were assessed 6 months after the surgery by reviewing medical records and photographs to assess the aesthetic outcomes, the relapse rate, and the incidence of complications.

Results
In the aesthetic outcome assessment, 86 patients were graded as good and 4 were graded as fair; of the latter, 2 had uneven scars and 2 showed showed a slight asymmetry of the double eyelid curve in length or width. Two patients were graded as poor because of the disappearance of the double eyelid crease. The relapse rate was 2.2%. Two patients had temporary hematoma. Six patients had lagophthalmos that subsided within 30 days. No cases of infection or ptosis were observed.

Conclusions
The bridge technique is an effective method for creating dynamic, natural-looking double eyelids. However, the long-term outcome of this new surgical approach requires further study.

Level of Evidence: 4
When phylogeography meets niche suitability to unravel the evolutionary history of a shrub from the Brazilian Atlantic Forest
Authors: Mäder Geraldo , Zamberlan Priscilla M , Segatto Ana Lucia A , Stehmann João R , Bonatto Sandro L , Freitas Loreta B 
Published: July 2020

AbstractThe Brazilian Atlantic Forest (BAF) is one of the most impacted biomes in the world, and in this region, there are several examples of the effects of Pleistocene climate changes among the species found there. Athenaea fasciculata (Solanaceae) is a forest component distributed mainly throughout the BAF extension. Here, we investigated the genetic diversity and population structure of A. fasciculata based on plastid and nuclear markers, aiming to better understand the impact of Pleistocene climate changes on BAF vegetation. We used population genetics, demographic methods and ecological niche modelling coupled to an evolutionary approach to describe the species distribution across time. The phylogeographic analysis of A. fasciculata indicated that Pleistocene climate changes played an important role in its evolution. The species is structured in two groups of populations that emerged from different refugia and were under different climate influences, supporting previously proposed connections between the Atlantic and Amazon Forests, the two most important Neotropical rainforests.
Predictive sensorimotor control in autism
Authors: Arthur Tom , Vine Sam , Brosnan Mark , Buckingham Gavin 
Published: July 2020

Abstract
Autism spectrum disorder has been characterized by atypicalities in how predictions and sensory information are processed in the brain. To shed light on this relationship in the context of sensorimotor control, we assessed prediction-related measures of cognition, perception, gaze and motor functioning in a large general population (n = 92; Experiment 1) and in clinically diagnosed autistic participants (n = 29; Experiment 2). In both experiments perception and action were strongly driven by prior expectations of object weight, with large items typically predicted to weigh more than equally-weighted smaller ones. Interestingly, these predictive action models were used comparably at a sensorimotor level in both autistic and neurotypical individuals with varying levels of autistic-like traits. Specifically, initial fingertip force profiles and resulting action kinematics were both scaled according to participants’ pre-lift heaviness estimates, and generic visual sampling behaviours were notably consistent across groups. These results suggest that the weighting of prior information is not chronically underweighted in autism, as proposed by simple Bayesian accounts of the disorder. Instead, our results cautiously implicate context-sensitive processing mechanisms, such as precision modulation and hierarchical volatility inference. Together, these findings present novel implications for both future scientific investigations and the autism community.
GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells
Authors: Park Ga-Bin , Jeong Jee-Yeong , Kim Daejin 
Published: July 2020

AbstractIn cancer, resistance to chemotherapy is one of the main reasons for therapeutic failure. Cells that survive after treatment with anticancer drugs undergo various changes, including in cell metabolism. In this study, we investigated the effects of AKT-mediated miR-125b-5p alteration on metabolic changes and examined how these molecules enhance migration and induce drug resistance in colon cancer cells. AKT1 and AKT3 activation in drug-resistant colon cancer cells caused aberrant downregulation of miR-125b-5p, leading to GLUT5 expression. Targeted inhibition of AKT1 and AKT3 restored miR-125b-5p expression and prevented glycolysis- and lipogenesis-related enzyme activation. In addition, restoring the level of miR-125b-5p by transfection with the mimic sequence not only significantly blocked the production of lactate and intracellular fatty acids but also suppressed the migration and invasion of chemoresistant colon cancer cells. GLUT5 silencing with small interfering RNA attenuated mesenchymal marker expression and migratory activity in drug-resistant colon cancer cells. Additionally, treatment with 2,5-anhydro-d-mannitol resensitized chemoresistant cancer cells to oxaliplatin and 5-fluorouracil. In conclusion, our findings suggest that changes in miR-125b-5p and GLUT5 expression after chemotherapy can serve as a new marker to indicate metabolic change-induced migration and drug resistance development.
Antiviral Activity and Pharmacokinetics of the Hepatitis B Virus (HBV) Capsid Assembly Modulator GLS4 in Patients With Chronic HBV Infection
Authors: Zhang Hong , Wang Fengjiao , Zhu Xiaoxue , Chen Yunfu , Chen Hong , Li Xiaojiao , Wu Min , Li Cuiyun , Liu Jingrui , Zhang Yingjun , Ding Yanhua , Niu Junqi 
Published: July 2020

Abstract

Background
GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator (class I) that can inhibit HBV replication by interfering with the assembly and disassembly of HBV nucleocapsid. Here, we evaluated its antiviral activity, pharmacokinetics, and tolerability in a double-blind, randomized, parallel, entecavir-controlled study.

Methods
Twenty-four patients with chronic HBV were randomized to receive a 28-day course of GLS4 (120 or 240 mg) and ritonavir (100 mg) combination (cohorts A and B, respectively) or entecavir treatment (cohort C) at a 1:1:1 ratio. Patients were followed up for 40 days in a phase 1b study.

Results
The GLS4/ritonavir combination was a tolerated combination for the treatment of chronic HBV infection. A total of 2, 3, and 3 subjects presented with alanine aminotransferase flare in cohorts A, B, and C, respectively. This contributed to the withdrawal of 1, 2, and 1 patient from cohorts A, B, and C, respectively. The mean Ctrough of GLS4 was 205–218 ng/mL, which was approximately 3.7–3.9 times the 90% effective concentration (55.8 ng/mL), with a lower accumulation (accumulation rate, 1.1–2.0). In cohorts A, B, and C, the mean declines in HBV DNA after 28 days of treatment were −1.42, −2.13, and −3.5 log10 IU/mL; in hepatitis B surface antigen were −0.06, −0.14, and −0.33 log10 IU/mL; in pregenomic RNA were −0.75, −1.78, and −0.96 log10 copies/mL; and in hepatitis B core antigen were −0.23, −0.5, and −0.44 log10 U/mL, respectively.

Conclusions
Treatment with 120 mg GLS4 was tolerated and had antiviral activity in patients with chronic HBV infection.

Clinical Trials Registration
Chinese Clinical Trial Registry; CTR20160068. http://www.chinadrugtrials.org.cn.
Personalized Therapy Approach for Hospitalized Patients with Coronavirus Disease 2019
Authors: Garcia-Vidal Carolina , Moreno-García Estela , Hernández-Meneses Marta , Puerta-Alcalde Pedro , Chumbita Mariana , Garcia-Pouton Nicole , Linares Laura , Rico Verónica , Cardozo Celia , Martínez José Antonio , García Felipe , Mensa Josep , Castro Pedro , Nicolás José María , Muñoz José , Vidal David , Soriano Alex ,   COVID19-Researchers, Bodro Marta , Morata Laura , Ambrosioni Juan , Agüero Daiana , Torres Berta , González Ana , De la Mora Lorena , Linares Laura , Meira Fernanda , Macaya Irene , Rodriguez Natalia , Nicolas David , Albiach Laia , Almuedo Alex , Angeles Marcos Mª , Angeles Marcos Mª , Fernandez-Pittol Mariana , Fidalgo Berta , Camprubí Daniel , Cilloniz Catia , Torres Antoni , Tellez Adrian , Fernández Sara , Sanjuan Gemma , Cano Pau , Caellas David 
Published: July 2020

Abstract
Hospitalized patients with coronavirus disease 2019 (COVID-19) experiencing respiratory symptoms have different complications (inflammatory, co-infection, and thrombotic) that are identifiable by analytics patterns. Personalized treatment decisions decreased early mortality (odds ratio [OR] .144; 95% confidence interval [CI] .03–.686; P = .015). Increasing age (OR 1.06; P = .038) and therapeutic effort limitation (OR 9.684; P &lt; .001) were associated with higher mortality.
Infection in a Young Immunocompetent Male Caused by Streptobacillus felis, a Putative Zoonotic Microorganism Transmitted by Cats
Authors: Matt Ulrich , Schmiedel Judith , Fawzy Ahmad , Trauth Janina , Schmidt Katja , Vogel Klaus , Herold Susanne , Karrasch Thomas , Imirzalioglu Can , Eisenberg Tobias 
Published: July 2020

Abstract
Rat bite fever (RBF) is predominantly caused by Streptobacillus moniliformis. We report a human infection with Streptobacillus felis. Clinical presentation was consistent with RBF, but serologic testing was negative for S moniliformis. Eventually, S felis–specific sequences were detected in skin lesions of the patient and in the oropharynx of local cats.
Central apnoeas and ticagrelor-related dyspnoea in patients with acute coronary syndrome
Authors: Giannoni Alberto , Borrelli Chiara , Gentile Francesco , Mirizzi Gianluca , Coceani Michele , Paradossi Umberto , Vergaro Giuseppe , Bramanti Francesca , Iudice Giovanni , Emdin Michele , Passino Claudio 
Published: July 2020

Abstract

Aims
Dyspnoea often occurs in patients with acute coronary syndrome (ACS) treated with ticagrelor compared with other anti-platelet agents and is a cause of drug discontinuation. We aimed to explore the contribution of central apnoeas (CA) and chemoreflex sensitization to ticagrelor-related dyspnoea in patients with ACS.

Methods and results
Sixty consecutive patients with ACS, preserved left ventricular ejection fraction, and no history of obstructive sleep apnoea, treated either with ticagrelor 90 mg b.i.d. (n = 30) or prasugrel 10 mg o.d. (n = 30) were consecutively enrolled. One week after ACS, all patients underwent two-dimensional Doppler echocardiography, pulmonary static/dynamic testing, carbon monoxide diffusion capacity assessment, 24-h cardiorespiratory monitoring for hypopnoea–apnoea detection, and evaluation of the chemosensitivity to hypercapnia by rebreathing technique. No differences were found in baseline demographic and clinical characteristics, echocardiographic, and pulmonary data between the two groups. Patients on ticagrelor, when compared with those on prasugrel, reported more frequently dyspnoea (43.3% vs. 6.7%, P = 0.001; severe dyspnoea 23.3% vs. 0%, P = 0.005), and showed higher apnoea–hypopnoea index (AHI) and central apnoea index (CAI) during the day, the night and the entire 24-h period (all P &lt; 0.001). Similarly, they showed a higher chemosensitivity to hypercapnia (P = 0.001). Among patients treated with ticagrelor, those referring dyspnoea had the highest AHI, CAI, and chemosensitivity to hypercapnia (all P &lt; 0.05).

Conclusion
Central apnoeas are a likely mechanism of dyspnoea and should be screened for in patients treated with ticagrelor. A drug-related sensitization of the chemoreflex may be the cause of ventilatory instability and breathlessness in this setting.
Pulmonary hypertension after pneumonectomy: a preclinical model in rats and human pulmonary endothelial cells
Authors: Sentenac Pierre , Samarani Gianluca , Bideaux Patrice , Sicard Pierre , Bourdois Benjamin , Richard Sylvain , Colson Pascal H , Eddahibi Saadia 
Published: July 2020

Abstract

OBJECTIVES

Pulmonary hypertension and heart disease contribute to the high morbidity rate following pneumonectomy (PN). The pathophysiology is still poorly understood. The objective was to investigate the consequences of PN on cardiopulmonary function in rats and to explore in vitro the involved mechanisms.

METHODS
Sixty Sprague-Dawley male rats randomly underwent either a right PN (PN group) or sham surgery. Ten rats per group were sacrificed on postoperative days 3, 7 and 28. Cardiopulmonary alterations were investigated by echocardiographic, haemodynamic and histological analyses. In vitro, the shear stress was reproduced using a Flexcell Tension™ cyclic stretch on cultured human pulmonary endothelial cells (P-ECs) to investigate the impact on pulmonary artery smooth muscle cell (PA-SMC) growth. Data are expressed as mean ± SD.

RESULTS
Mean pulmonary arterial pressure gradually increased in the PN group to reach 35 ± 7 mmHg on postoperative day 28 vs 18 ± 4 in sham (P = 0.001), likewise the proportion of muscularized distal pulmonary arteries, 83 ± 1% vs 5 ± 1%, respectively (P &lt; 0.001), related to in situ PA-SMC proliferation. The right ventricle area and lateral wall thickness were doubled in the PN group on postoperative day 28. The left ventricle ejection fraction decreased on postoperative days 7 and 28 while the right ventricle function was maintained. In vitro, the human PA-SMC growth was significantly greater when seeded with stretched vs non-stretched P-EC media, highlighting the role of shear stress on the P-EC paracrine function.

CONCLUSIONS
Right PN led to pulmonary hypertension and proportional right heart remodelling in rats. The shear stress related to high blood flow alters the pulmonary endothelial paracrine control of SMC growth.