bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Testosterone in Serum and Follicular Fluid in Sub Fertile Women Undergo Intracytoplasmic Sperm Injection
Authors: A. Al-Awadi Marwa , AL- Awadi Marwa , Al-Bdairi Aseel , Ibrahim Ali 
Published: December 2024

Background: Testosterone is the most common and regarded as the main hormone in the testicles among androgen (Tremblay, J. J. (2015) Testosterone synthesis is initiated by luteinizing hormone and cAMP signaling, promoting the transport of cholesterol to the inner mitochondrial membrane with the involvement of the steroidogenic acute regulatory protein (StAR). Cholesterol is then converted into pregnenolone, which further transforms into progesterone and is eventually metabolized into testosterone. This steroidogenesis pathway is similar in both thecae cells and interstitial cells of the ovaries (Cipolla-Neto, J., et al., 2022). Low-quality oocytes with a propensity for lower cleavage rates following fertilization have been associated with elevated androgen levels, more especially testosterone, in follicular fluid (FF) (Costa, L. O. B., et al., 2004). When FF contained immature oocytes as opposed to mature oocytes, testosterone levels were found to be noticeably higher. Pregnancy-associated follicles were found to have a higher estrogen-to-testosterone (E2/T) ratio reported. These results raise the possibility that an early follicular atresia linked to a low estrogen/androgen ratio in FF may reduce the viability of the oocytes and reduce the likelihood of fertilization and pregnancy purpose: to detect the follicular fluid and blood concentration of the testosterone hormone on subfertility in women undergoing Intracytoplasmic Sperm Injection (ICSI) for fertility treatment. Methods: This case-control study was carried out on eighty women, from these, forty females were sub-fertile patients defined as the cases, other forty females as a control included fertile females came to fertility center due to males factor of subfertility. A detailed medical history and physical examination were recorded. At the same day of ovum pickup blood and follicular fluid were collected, for hormonal analysis of testosterone. Results: Show significantly higher levels of serum and follicular testosterone in sub-fertile women (cases) than control group (p < 0.05), and significant positive correlations between serum and follicular fluid. Additional materials: notes the number of references, tables, graphs, exhibits, test instruments, appendixes, or other supplemental materials in the paper. Also, the abstract must be written in a single paragraph in English, max 250 words. Conclusion: Testosterone hormone level in blood and follicular fluid were significantly higher in cases group than control and there is a positive correlations between serum and follicular fluid of testosterone.
Acute Kidney Injury in Children with Diabetic Ketoacidosis
Authors: Hamoodi Anfal MB. , Asif Wid Abdul Razak , Salih Bushra Jalil , Al Awqati Tala Anwar 
Published: December 2024

Backgrounds and Objectives: Diabetic ketoacidosis is frequent in type I diabetic children, and as acute kidney injury has a well-known morbidity, this study aims to determine the frequency and associated factors of acute kidney injury in these children. Material and Methods: A prospective study conducted on type I diabetic children with diabetic ketoacidosis admitted at Central Child Teaching Hospital; during February 2020 - January 2021. The study includes 96 patients, aged < 15 years. Demographic and clinical information collected for each patient, including ( age, gender, onset of diabetes, previous diabetic ketoacidosis, recurrent urinary tract infection). At admission all patients underwent clinical assessment of their heart rate and amount of resuscitation boluses given; and weight and height measured. PH and HCO3 levels used to categorize diabetic ketoacidosis severity. Kidney Disease Improving Global Outcomes S.creatinine criteria used to identify acute kidney injury. Estimated basal creatinine using modified Schwartz formula, with glomerular filtration rate 120 ml/min/m2 was used. Logistic regression analysis used to identify risk factors. Results: A total 19 (19.8%) participants developed acute kidney injury(AKI) at 24hrs hospitalization [ 15 (78.9%) cases AKI stage I, 2 (10.5%)cases AKI stage II, and 2 (10.5%)cases AKI stage III ]. One child required peritoneal dialysis at second day of admission. Diabetic ketoacidosis severity odds for AKI reached 5.5 and increased to 13.3 with increasing heart rate. Conclusions: Acute kidney injury occurred in one in five of children during diabetic ketoacidosis with ketoacidosis severity and high heart rate at admission is an important associated factors.
الحكاية في النحو العربيّ، التحجّر الفعّال، دراسة تحليلية
Authors: عبد حسام قدوري 
Published: December 2024

النمطية، أو التراتبية، أو السلاسل المتناغمة، سمّها ما شئت تحكم بمسمى واحد؛ هو الإعراب، فإذا ما حدث أن كُسر ذلك كلّه فإنّه سيكون مدعاةً للاستغراب، أو عُسر الفهم؛ إذ كيف يمكنُ تفسير ذلك التأثير بين الكلمة والأخرى، والجملة والأخرى في ضوء علاقات جديدة محكومة بالخطأ مسبقاً!
الحكاية ليست بديلاً نموذجياً للإعراب ؛ فاللغات الساميّة تميل في الغالب إلى طرح الإلغاء - أي إلغاء الإعراب - بديلاً عنه، أمّا الحكاية فليست كذلك ؛ إنها محاولة لخرق القاعدة ، وكسر القيود ، فهي أقرب في ذلك إلى الضرورة الشعرية ، لكنّها تختلف عن الضرورة في كون الضرورة تكون مقبولة مستساغة في معادلة ما هو عروضي موسيقي في مقابل ما هو نحوي ، فالضرورة صفقة رابحة بين النحو، والموسيقى، بيد أن الحكاية لا تخضع لمرابحة تفرضها التفعيلات ، والبحور ، إنها مفروضة بجدّية وقصدية فاعلة في لعبة النصّ والمعنى، وهذا الأمر قد لا يلتفت إليه جنون الشعراء.
هذا البحث يتكفل بدراسة ظاهرة الحكاية الكاسرة لظاهرة الإعراب في واحدة من اللغات الساميّة؛ وهي اللغة العربية في ضوء ظاهرة تحجّر اللغة، ومديات توظيفها النحويّ، والدلاليّ، ولا سيّما في تقنيات التناص.
نمط الإيقاع الحيوي اليومي (الصباحيين _ المسائيين) لدى عينة من طلاب الجامعة في ضوء بعض المتغيرات
Authors: شيبان عبد الحميد محمد 
Published: December 2024

هدف هذا البحث إلى التحقق من الخصائص السيكومترية لمقياس الإيقاع الحيوي اليومي (الصباحيين _ المسائيين) وفق متغيرات الجنس والاختصاص والمعدل التحصيلي لدى طلبة المرحلة الجامعية في جامعة حلب في الجمهورية العربية, واتبع الباحثان المنهج الوصفي التحليلي, وتكونت عينة هذا البحث من 100طالب وطالبة, تراوحت أعمارهم بين (25 -19) عاماً بمتوسط حسابي (21.8) وانحراف معياري (0.643), وتم استخدام مقياس إيقاع الساعة البيولوجية اليومي (الصباحي _ المسائي) إعداد تيرمان وآخرون عام (2001), والتقدير العام لمجموع المواد الدراسية الذي حصل كل فرد من أفراد العينة لعام2022/2023.
وقد أظهرت نتائج البحث:

وجود فروق ذات دلالة إحصائية في نمط الإيقاع والمتوسط الفرضي مما يعني أن نمط الإيقاع أعلى من المتوسط لدى أفراد العينة.
عدم وجود فروق ذات دلالة إحصائية في متوسط نمط الايقاع تبعاً لمتغير الاختصاص والمعدل.
وجود فروق ذات دلالة إحصائية في متوسط نمط الايقاع تبعاً لمتغير الجنس ولصالح الذكور.
الفكر النقدي العربي وصراع الهوية قراءة في كتابي عبد العزيز حمودة
Authors: جمعة رؤى بشير , السعدون أحمد غالب 
Published: December 2024

شغلت النظرية نقدية عربية فكر العديد من النقاد ومنذ زمن طويل، ولعدة أسباب منها شعورهم بالتبعية الثقافية، فضلا عن مواجهتهم للعديد من المشكلات في تطبيق المناهج الغربية على الواقع العربي المتميز باضطراباته الخاصة، أن شعور الباحثين بأننا نعيش حالة من عدم الفهم التام لهذه المناهج خلق نوعًا من الازدواجية الثقافية، هذا الأمر جعلنا نعود لبعض المصادر لنبحث أين تكمن المشكلة في إيجاد نظرية نقدية عربية أصيلة تتناسب والنص ألأدبي، علمًا أن وجود نظرية نقدية عربية لا تصب في مصلحة الناقد فقط، بل في مصلحة المبدع أيضًا والقارئ الذي لن يشعر بأن هناك مسافة شرخ بين النص والتأويل. الأمر ألأخر الذي عول عليه البحث هو فكرة الهوية العربية وكيف أثرت على النتاج الإبداعي، وهل حقًا تشكل الهوية التأريخ الحقيقي لحضارة ما.
PENGARUH TERAPI DESENSITISASI SISTEMATIS UNTUK GANGGUAN KECEMASAN: SISTEMATIKA REVIEW
Authors: Puja Maudy Lawinsky  , Tristiadi Ardi Ardani  
Published: December 2024

Penelitian ini bertujuan untuk mengetahui efektivitas terapi desensitisasi sistematis dalam mengurangi gangguan kecemasan. Penelitian ini menggunakan metode tinjauan literatur (Systematic Literature Review) dengan menggali data yang relevan mengenai seberapa banyak penelitian yang telah dilakukan oleh para peneliti dalam pengaruh terapi desensitisasi sistematis terhadap gangguan kecemasan. Data dikumpulkan melalui pencarian artikel yang diterbitkan dalam kurun waktu tujuh tahun terakhir (2017–2024) dari beberapa database elektronik. Hasil penelitian menunjukkan bahwa terapi desensitisasi sistematis efektif dalam mengurangi gangguan kecemasan. Faktor-faktor yang mempengaruhi keberhasilan dalam melakukan terapi desensitisasi sistematis yaitu tingkat motivasi terhadap individu untuk mengurangi kecemasan yang dialaminya, tingkat kesadaran diri akan cemas yang berlebihan, serta keterampilan terapis. Individu yang memiliki tingkat kecemasan yang masih rendah dan mendapatkan durasi atau sesi terapi yang lebih intensif maka hasilnya akan lebih baik. Peneliti ini memberikan pengetahuan mendalam mengenai pentingnya terapi Desentalisasi dalam mengatasi gangguan kecemasan serta implikasi terhadap intervensi psikologi.
This study aims to determine the effectiveness of systematic desensitization therapy in reducing anxiety disorders. This study uses the systematic literature review method by exploring relevant data on how much research has been conducted by researchers on the effect of systematic desensitization therapy on anxiety disorders. Data were collected through searching articles published within the last seven years (2017-2024) from several electronic databases. The results showed that systematic desensitization therapy is effective in reducing anxiety disorders. Factors that influence success in conducting systematic desensitization therapy are the level of motivation for individuals to reduce the anxiety they experience, the level of self-awareness of excessive anxiety, and the skills of the therapist. Individuals who have low levels of anxiety and get more intensive duration or therapy sessions will have better results. This researcher provides in-depth knowledge about the importance of Decentalization therapy in overcoming anxiety disorders and implications for psychological interventions.
TEKNOLOGI TRADISIONAL PEMBUATAN TOPĒ LE’LENG PADA KOMUNITAS ADAT KAJANG DI KABUPATEN BULUKUMBA
Authors: Ansaar Ansaar 
Published: December 2024

Materi tulisan ini adalah merupakan hasil penelitian lapangan yang dilaksanakan di Desa Tana Toa Kecamatan Kajang, Kabupaten Bulukumba. Penelitian ini bertujuan selain untuk mendeskripsikan teknik pembuatan tope le’leng (sarung hitam Kajang) pada komunitas adat Kajang, juga untuk mengetahui bentuk pola pewarisan yang diterapkan para orang tua kepada anaknya terkait keterampilan dalam hal menenun. Metode penelitian yang digunakan adalah deskriktif kualitatif dengan teknik pengumpulan data berupa wawancara, pengamatan dan kajian pustaka. Hasil penelitian ini menunjukan, bahwa teknik pembuatan sarung hitam Kajang oleh komunitas adat Kajang, melalui beberapa tahapan, yaitu: 1) pencelupan benang ke dalam pewarna alami, 2) penghanian atau penyusunan benang lunsing (ma’ngane), 3) pembuatan benang pakan (a’paturung), 4) proses pertenunan (attannung), dan 5) menggosok permukaan kain sarung (maggarusu’) setelah selesai ditenun. Bentuk pola pewarisannya, berlangsung secara transmisi dari generasi ke generasi atau dari orang tua ke anak-anaknya dan seterusnya, atau melalui jalur keluarga. Tidak ada pendidikan khusus yang mereka lalui, semua berawal dari pembelajaran yang diberikan para orang tua kepada anaknya. Hal pertama yang diajarkan, adalah memperkenalkan bagian-bagian atau komponen pada peralatan tenun berikut fungsinya. Setelah itu barulah diajarkan cara mengoperasionalkan alat tenun secara tahap demi tahap.
Lisser l’avenir : le « journal » de Patrick Gass et la peinture de l’Ouest
Authors: ATEM Florent 
Published: December 2024

Lorsqu’il entame en mai 1804 la remontée du Missouri en tant que membre de l’expédition Lewis et Clark, Patrick Gass ignore qu’il s’apprête à jouer un rôle fondamental au sein du Corps de la découverte. Outre les innombrables services rendus dans le cadre du périple jusqu’à la côte Pacifique, le charpentier de la troupe est également l’un des sept diaristes du groupe. Publié dès 1807, un an après le retour triomphal à Saint-Louis, son récit de l’aventure constituera, sept années durant, l’unique témoignage de l’épopée américaine jusqu’aux confins de la wilderness ; véritable invitation au voyage, il attisera à lui seul la flamme du désir expansionniste. En ce sens, au-delà du caractère en apparence linéaire et chronologique de sa narration, bien plus qu’une expérience passée léguée à la postérité, c’est bel et bien une vision de l’avenir de la nation que Gass, au fil des pages de son « journal », donne à voir à ses concitoyens.
Rire aux éclats en lisant Fabrice Caro alias Fabcaro. Quand l’humour voyage de la bande dessinée au roman
Authors: Demoulin Laurent 
Published: December 2024

Fabrice Caro est surtout connu, sous le pseudonyme de Fabcaro, comme dessinateur et scénariste de bandes dessinées (il est l’auteur, notamment, de Zaï zaï zaï paru en 2015 et du scénario d’un épisode d’Astérix, L’iris blanc). Mais, depuis ses débuts, il poursuit en parallèle une carrière de romancier. L’humour dans les deux pans de son œuvre correspond assurément à un enjeu spécifique tant il est omniprésent. On peut, en effet, sans trop de risque, affirmer que le rire est au cœur de sa poétique. Le présent article a pour but de cartographier les procédés et les dispositifs humoristiques à l’œuvre dans les romans de Fabrice Caro : le comique de caractère, la satire sociale, les références culturelles contrastées, les situations incongrues, l’humour noir, l’humour sexuel, scatologique ou urologique, le running gag, les calembours, les parodies, les exagérations, la mauvaise foi. Brièvement, en conclusion, ces procédés seront comparés avec ceux qui sont exploités et mis en place dans ses bandes dessinées signées Fabcaro. Fabrice Caro adapte-t-il sa palette humoristique au genre pratiqué ? Telle sera la question à laquelle nous chercherons à répondre in fine.
Le gai savoir de Mathias Énard
Authors: Fontaine Kathryne 
Published: December 2024

Cet article analyse la manière dont Mathias Énard manie l’humour et l’érudition dans Le banquet annuel de la Confrérie des fossoyeurs, une œuvre où le rire se conjugue avec une réflexion profonde sur l’existence et la connaissance. En s’inspirant du concept de “gai savoir” de Nietzsche, l’étude montre comment ce roman d’Énard constitue un hommage contemporain à la sagesse joyeuse.
Le rire des récits de transfuges
Authors: Moricheau-Airaud Bérengère 
Published: December 2024

Contribuer à l’exploration de la place accordée au rire par la littérature francophone contemporaine implique d’examiner les formes, les mécanismes et les fonctions du rire dans l’écriture des récits de transfuges, ceux d’Annie Ernaux principalement, ceux de ses épigones également, qui se multiplient ces dernières années. Le rire y assure la démarcation des groupes, car il sépare ceux qui rient de ceux qui ne rient pas, ceux dont on rit de ceux qui en rient, ceux à qui la volonté de s’élever ne laisse pas d’autre choix que de rire avec les autres. Le rire est aussi un marqueur de groupe car il en est une caractéristique notable : le rire est propre au cercle auquel on appartient, à sa classe, à son âge considéré. Le rire, par sa distanciation, par sa mise en situation, par son émancipation, est un témoin et une ressource de distinction sociale.
Phytochemicals from Pyrrosia longifolia (Burm. f.) C.V. Morton with antibacterial activity
Authors: Teruna Hilwan Yuda , Khodijah Rohimatul , Frimayanti Neni , Hendra Rudi 
Published: December 2024

Background and purpose:

Pyrrosia longifolia is one of the medicinal plants in Indonesia. However, it has received little attention regarding pharmacological properties and phytochemicals. This study aimed to isolate bioactive compounds and evaluate their antibacterial activities.

Experimental approach:
The secondary metabolites were isolated using a bioassay-guided approach. The aerial part was macerated in methanol and the crude methanol was partitioned with organic solvents to obtain n-hexane, dichloromethane, ethyl acetate, and water extracts. The ethyl acetate extract was purified using chromatography procedures, yielding six chemicals, and their structures were determined using spectroscopy. The antibacterial activity of the compounds was evaluated.

Findings/Results:
Six secondary phytochemical metabolites were identified including naringin (1), catechin (2), quercetin (3), rutin (4), kaempferol (5), and mangiferin (6). The absolute configurations of compounds 1 and 2 were ascertained using electronic circular dichroism as 2S for naringin and 2R, 3S for catechin. The compounds exhibited antibacterial activity against several pathogenic bacteria, with MIC and MBC values ranging from 7.8 to 250 μg/mL. Computational investigations of these compounds revealed a substantial affinity for bacterial receptors’ active and allosteric regions. Furthermore, rutin exhibited the capacity to reduce the activity of β-ketoacyl-acyl carrier protein synthase III, enhancing its antibacterial effectiveness.

Conclusion and implications:
The in-vitro assessment revealed that the six identified compounds possess a wide range of antibacterial activity, which was corroborated by in-silico analyses. However, further investigation is required to back up the conclusion of this study.
Synthesis, docking, pharmacokinetic prediction, and acetylcholinesterase inhibitory evaluation of N-(2-(piperidine-1-yl)ethyl)benzamide derivatives as potential anti-Alzheimer agents
Authors: Mohammadi-Farani Ahmad , Moradi Farzaneh , Hosseini Amin , Aliabadi Alireza 
Published: December 2024

Background and purpose:
Alzheimer’s disease is the most common form of dementia and the sixth most common cause of death in the US according to the Alzheimer’s Association. As regards, to date, no effective treatments are available because of the multifactorial nature of the disease, therefore, a large body of recent research has been allocated to the design and development of multi-target-directed ligands that can become effective drug candidates.

Experimental approach:
A novel series of benzamide derivatives (5a-5l) containing piperidine core were synthesized in the current work. After identification of the chemical structures of the members of this series using 1H NMR, IR, and MS spectra, their anti-acetylcholinesterase activity was assessed by the Ellman᾽s test. Docking studies were also performed to investigate the binding mode and determine the interacting amino acids with the corresponding ligands. Finally, the pharmacokinetic (ADME parameters) of the most potent derivative (5d) was predicted and compared with donepezil.

Findings/Results:
Compound 5d possessing the fluorine atom substitution at position ortho was the most active compound in these series (IC50 = 13 ± 2.1 nM). This compound demonstrated superior activity than the reference drug donepezil (IC50 = 0.6 ± 0.05 µM). Molecular docking showed a significant hydrogen bonding of the carbonyl group of compounds 5d with tyrosine 121 into the active site of acetylcholinesterase. Fortunately, this compound showed better promising ADME properties than donepezil.

Conclusion and implication:
The benzamide derivatives introduced in this paper could be proposed as potential anti-acetylcholinesterase.
Ultra-small phospholipid nanoparticles in the treatment of combined hyperlipidemia: a randomized placebo-controlled clinical trial
Authors: Archakov Alexander , Kukharchuk Valery , Lisitsa Andrey , Ponomarenko Elena , Romashova Yulia , Pleshakova Tatiana , Yarovaya Elena , Kutsenko Vladimir , Guseva Maria , Beregovykh Valery , Ipatova Olga , Zubareva Marina , Tikhonova Elena , Ivanov Sergei , Bedretdinov Farid , Markin Sergey 
Published: December 2024

Background and purpose:
Combined hyperlipidemia is associated with an increased risk of cardiovascular events. This clinical trial investigated phospholipovit (essential phospholipids, Institute of Biomedical Chemistry, Moscow, Russia), an ultra-small phospholipid nanoparticle (micelles), targeted to phospholipids of HDL in lowering non-HDL-cholesterol (non-HDL-C) and triglycerides (TG) levels in patients with combined hyperlipidemia and moderate cardiovascular risk.

Experimental approach:
A randomized, double-blinded, placebo-controlled phase II trial was conducted on 100 patients. Phospholipovit or placebo was randomly administered orally (500 mg) 2 times a day for 12 weeks. The primary endpoint was the percent change of non-HDL-C from baseline to 12 weeks of exposure.

Findings/Results:
Treatment with phospholipovit resulted in a mean non-HDL-C reduction of 13.2% versus 4.3% compared with placebo. The absolute decrease in non-HDL-C was -23.2 (-48.7 - 7.0) mg/dL versus -7.3 (-17.0 - 12.0) mg/dL, significantly. The therapeutic target of non-HDL-C less than 130 mg/dL (3.4 mmol) was achieved in 15 of 39 patients (38.5%) in the phospholipovit group versus 2 of 41 patients (4.9%) in the placebo group OR 11.8 (2.4 - 116). Significant reduction in TG, apolipoprotein B, total cholesterol, and very low-density lipoprotein cholesterol levels was also observed. There were no changes in the liver and kidney functions, vital signs, or electrocardiography. There were no serious adverse events.

Conclusion and implications:
Phospholipovit significantly reduced non-HDL-C, TG, and atherogenic lipoproteins in patients with combined hyperlipidemia and moderate cardiovascular risk. It can be used as an add-on therapy to statins.
Sense of Community and Emotional Regulation: Interconnections Leading to Flourishing Among Single Catholics
Authors: Tambun Ivy Novenatha Karolina , Nanik Nanik , Sampe Tondok Marselius 
Published: December 2024

Modernization and individualistic culture have shifted the values and expectations of the younger generation regarding marriage, leading to delays or decisions not to marry. However, in Indonesia, many single individuals still face social pressure due to societal stigma, as well as religious and cultural values. This pressure can negatively impact the well-being or flourishing of single individuals. This study aims to examine the relationship between sense of community and emotion regulation (cognitive and expressive suppressions) with flourishing among single individuals, using a correlational quantitative method with 105 respondents (Mage = 34.90; SD = 5.84 years) from the Catholic Singles Community “J”. A purposive sampling technique was employed to select the sample. The results of multiple correlation indicated that sense of community and emotion regulation together significantly positively correlate with flourishing (R = 0.293, R2 = 0.086, p < 0.05. Nevertheless, partial correlation analysis revealed a significant positive correlation between the sense of community and flourishing (p<0.05), but a non-significant correlation between emotion regulation (both cognitive and expressive suppression) and flourishing (p>0.05). Although emotion regulation did not directly correlate with flourishing, emotion regulation (cognitive and expressive suppression) were significantly positively correlated with most aspects of sense of community. The implications of this research suggest that enhancing the sense of community plays a crucial role in achieving flourishing among members of a community. Sense of community can be further strengthened when supported by emotion regulation skills within the community context.