bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the Minority Stress Theory: Understanding the Mental Health of Undocumented Latinx Immigrants
Authors: Valentín‐Cortés Mislael , Benavides Quetzabel , Bryce Richard , Rabinowitz Ellen , Rion Raymond , Lopez William D. , Fleming Paul J. 
Published: August 2020

AbstractThis paper applies the Minority Stress framework to data collected from an ongoing community‐based participatory research project with health and social service agencies in Southeast Michigan. We examine the stressors and coping strategies employed by undocumented Latinx immigrants and their families to manage immigration‐related stress. We conducted in‐depth interviews with 23 immigrant clients at Federally Qualified Health Care Centers (FQHC) in Southeast Michigan and 28 in‐depth interviews with staff at two FQHC's and a non‐profit agency serving immigrants. Findings suggest that immigrants face heightened anxiety and adverse mental health outcomes because of unique minority identity‐related stressors created by a growing anti‐immigrant social environment. Chronic stress experienced stems from restrictive immigration policies, anti‐immigrant rhetoric in the media and by political leaders, fear of deportation, discriminatory events, concealment, and internalized anti‐immigrant sentiment. Though identity can be an important effect modifier in the stress process, social isolation in the immigrant community has heightened the impact of stress and impeded coping strategies. These stressors have resulted in distrust in community resources, uncertainty about future health benefits, delayed medical care, and adverse mental health outcomes. Findings provide a framework for understanding the unique stressors experienced by immigrants and strategies for interventions by social service agencies.
A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome
Authors: Saygin Caner , Larkin Karilyn , Blachly James S. , Orwick Shelley , Ngankeu Apollinaire , Gregory Charles T. , Phelps Mitch A. , Mani Shylaja , Walker Alison , Garzon Ramiro , Vasu Sumithira , Walsh Katherine J. , Bhatnagar Bhavana , Klisovic Rebecca B. , Grever Michael R. , Marcucci Guido , Byrd John C. , Blum William , Mims Alice S. 
Published: August 2020

AbstractPatients with relapsed/refractory (R/R) acute myeloid leukemia (AML) have poor outcomes and hematopoietic cell transplantation (HCT) is the only curative treatment. New targeted therapies improved survival in select patients with specific mutations, however management of patients without these molecular alterations is an unmet need. We conducted a phase one study of lenalidomide in combination with cytarabine/idarubicin salvage chemotherapy in patients with R/R AML and high‐risk myelodysplastic syndromes. A total of 33 patients were enrolled in the study (30 AML, 3 MDS), and treated at three dose levels with 3 + 3 design. Dose‐limiting toxicity (DLT) was seen in eight patients, including four hematologic DLTs. The most commonly observed non‐hematologic serious adverse events were febrile neutropenia, rash, sepsis and renal injury. Dose level −1, consisting of 25 mg/d lenalidomide D1‐21, 1 g/m2 cytarabine D5‐8, and 8 mg/m2 idarubicin D5‐7 was determined to be the maximum tolerated dose. Note, 15/33 (45%) of patients were able to receive pre‐planned 21 days of lenalidomide. Overall, 18 patients achieved complete remission (CR) (n = 14) or CR with incomplete count recovery (CRi) (n = 4) with total CR/CRi rate of 56%. The 1‐year and 2‐year overall survival (OS) were 24% and 10%, respectively. Among responders, 10/18 underwent allogeneic HCT and had a 1‐year OS of 40%. There was no molecular pattern associated with response. These data demonstrate that the combination had clinical activity in R/R AML. This regimen should be further investigated for patients who relapsed after HCT, and as a bridge therapy to HCT. (ClinicalTrials.gov identifier: NCT01132586).
Whole genome sequence analysis identifies a PAX2 mutation to establish a correct diagnosis for a syndromic form of hyperuricemia
Authors: Stevenson Mark , Pagnamenta Alistair T. , Reichart Silvia , Philpott Charlotte , Lines Kate E. ,   OxClinWGS, Gorvin Caroline M. , Lhotta Karl , Taylor Jenny C. , Thakker Rajesh V. 
Published: August 2020

AbstractHereditary hyperuricemia may occur as part of a syndromic disorder or as an isolated nonsyndromic disease, and over 20 causative genes have been identified. Here, we report the use of whole genome sequencing (WGS) to establish a diagnosis in a family in which individuals were affected with gout, hyperuricemia associated with reduced fractional excretion of uric acid, chronic kidney disease (CKD), and secondary hyperparathyroidism, that are consistent with familial juvenile hyperuricemic nephropathy (FJHN). However, single gene testing had not detected mutations in the uromodulin (UMOD) or renin (REN) genes, which cause approximately 30–90% of FJHN. WGS was therefore undertaken, and this identified a heterozygous c.226G>C (p.Gly76Arg) missense variant in the paired box gene 2 (PAX2) gene, which co‐segregated with renal tubulopathy in the family. PAX2 mutations are associated with renal coloboma syndrome (RCS), which is characterized by abnormalities in renal structure and function, and anomalies of the optic nerve. Ophthalmological examination in two adult brothers affected with hyperuricemia, gout, and CKD revealed the presence of optic disc pits, consistent with optic nerve coloboma, thereby revising the diagnosis from FJHN to RCS. Thus, our results demonstrate the utility of WGS analysis in establishing the correct diagnosis in disorders with multiple etiologies.
Lifestyle, multi‐omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study
Authors: Jiang Yanfeng , Cui Mei , Tian Weizhong , Zhu Sibo , Chen Jinhua , Suo Chen , Liu Zhenqiu , Lu Ming , Xu Kelin , Fan Min , Wang Jiucun , Dong Qiang , Ye Weimin , Jin Li , Chen Xingdong ,   the Taizhou Imaging Study Group
Published: August 2020

AbstractChina has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under‐researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long‐term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community‐based prospective cohort—the Taizhou Imaging Study (TIS)—to accelerate the understanding of dementia and cerebrovascular diseases in Chinese. This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data.
Implementation of a radiation injury management curriculum for health‐care professionals in Taiwan
Authors: Hsu Hsiang‐Chin , Hsieh Chih‐Chia , Chi Chih‐Hsien , Shih Hsin‐I 
Published: August 2020

AimRadiation‐related injury in the general population due to accidents or incidents is a rare but significant event that merits serious study and planning in the health‐care system. Therefore, we developed different levels of training courses targeting medical emergency response and treatment for radiation‐related injury in patients, for different health‐care professionals and medical students.MethodsThe curriculum, teaching instructions, and objectives were based on the working group consensus of first responders of radiation‐related injury. The working group included different specialists from hospitals, medical schools, and government radiation emergency response agencies.ResultsSeveral different course levels, including lectures, group discussions, case and scenario discussions, hands‐on practice, tabletop drills, and drills were included. The curriculums have shown that developing different levels of courses for medical students and health‐care professionals was feasible.ConclusionThrough the cooperation of different specialties and different interactive courses, the training programs were able to meet the initial education goals for medical emergency and radiation‐related injury for medical students and health‐care professionals.
Bis(perchlorocatecholato)germane: Hard and Soft Lewis Superacid with Unlimited Water Stability
Authors: Roth Daniel , Wadepohl Hubert , Greb Lutz 
Published: August 2020

AbstractPreviously described Lewis superacids are moisture sensitive and predominantly hard in character—features that severely limit their widespread use in orbital‐controlled reactions and under non‐inert conditions. Described here are adducts of bis(perchlorocatecholato)germane, the first hard and soft Lewis superacid based on germanium. Remarkably, the synthesis of this compound is performed in water, and the obtained H2O adduct constitutes a strong Brønsted acid. If applied as an adduct with aprotic donors, it displays excellent activity in a diverse set of Lewis acid catalyzed transformations, covering hydrosilylation, hydrodefluorination, transfer hydrogenation, and carbonyl–olefin metathesis. Given the very straightforward synthetic access from two commercially available precursors, the unlimited water stability and the soft Lewis acidic character, it promotes the transfer of Lewis superacidity into organic synthesis and materials science.
A Highly Lewis Acidic Strontium ansa‐Arene Complex for Lewis Acid Catalysis and Isobutylene Polymerization
Authors: Dabringhaus Philipp , Schorpp Marcel , Scherer Harald , Krossing Ingo 
Published: August 2020

AbstractThe potential of a dicationic strontium ansa‐arene complex for Lewis acid catalysis has been explored. The key to its synthesis was a simple salt metathesis from SrI2 and 2 Ag[Al(ORF)4], giving the base‐free strontium‐perfluoroalkoxyaluminate Sr[Al(ORF)4]2 (ORF=OC(CF3)3). Addition of an ansa‐arene yielded the highly Lewis acidic, dicationic strontium ansa‐arene complex. In preliminary experiments, the complex was successfully applied as a catalyst in CO2‐reduction to CH4 and a surprisingly controlled isobutylene polymerization reaction.
The Nature of Strong Chalcogen Bonds Involving Chalcogen‐Containing Heterocycles
Authors: Haberhauer Gebhard , Gleiter Rolf 
Published: August 2020

AbstractChalcogen bonds are σ hole interactions and have been used in recent years as an alternative to hydrogen bonds. In general, the electrostatic potential at the chalcogen atom and orbital delocalization effects are made responsible for the orientation of the chalcogen bond. Here, we were able to show by means of SAPT calculations that neither the induction (orbital delocalization effects) nor the electrostatic term is causing the spatial orientation of strong chalcogen bonds in tellurium‐containing aromatics. Instead, steric interactions (Pauli repulsion) are responsible for the orientation. Against chemical intuition the dispersion energies of the examined tellurium‐containing aromatics are far less important for the net attractive forces compared to the energies in the corresponding sulfur and selenium compounds. Our results underline the importance of often overlooked steric interactions (Pauli repulsion) in conformational control of σ hole interactions.
New N‐phenylacetamide‐linked 1,2,3‐triazole‐tethered coumarin conjugates: Synthesis, bioevaluation, and molecular docking study
Authors: Akolkar Satish V. , Nagargoje Amol A. , Shaikh Mubarak H. , Warshagha Murad Z. A. , Sangshetti Jaiprakash N. , Damale Manoj G. , Shingate Bapurao B. 
Published: August 2020

AbstractA series of new 1,2,3‐triazole‐tethered coumarin conjugates linked by N‐phenylacetamide was efficiently synthesized via the click chemistry approach in excellent yields. The synthesized conjugates were evaluated for their in vitro antifungal and antioxidant activities. Antifungal activity determination was carried out against fungal strains such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans. Compounds 7b, 7d, 7e, 8b and 8e displayed higher potency than the standard drug miconazole, with lower minimum inhibitory concentration values. Also, compound 7a exhibited potential radical scavenging activity as compared with the standard antioxidant butylated hydroxytoluene. In addition, a molecular docking study of the newly synthesized compounds was carried out, and the results showed a good binding mode at the active site of the fungal (C. albicans) P450 cytochrome lanosterol 14α‐demethylase enzyme. Furthermore, the synthesized compounds were also tested for ADME properties, and they demonstrated potential as good candidates for oral drugs.
A Contemporary Message from Mendel's Logical Empiricism
Authors: Huminiecki Łukasz 
Published: August 2020

AbstractThe gene is one of the most fundamental concepts in life sciences, having been developed in the mold of the Mendelian paradigm of heredity, which shaped genetics across 150 years. How could Mendel possibly be so prophetic in the middle of 19th century, using only the small garden of the monastery as his experimental breeding field? I believe that we are indebted to Mendel's mastery of the scientific method, which was far ahead of his time. Although his experimental technology was literally garden‐variety, Mendel's excellence in the method of science, algebra, and logical analysis helped him in designing the right experiment and in interpreting the results insightfully. This may be valuable to recall in today's technology‐focused culture, where the center of interest tends to be on the generation and description of high‐throughput datasets from specialized genomics screens. As Mendel's story suggests, progress in 21st century genetics may also depend on the development of robust concepts and generalizations.
Modeling the dynamic linkage between financial development, energy innovation, and environmental quality: Does globalization matter?
Authors: Baloch Muhammad Awais , Ozturk Ilhan , Bekun Festus Victor , Khan Danish 
Published: August 2020

AbstractIn the modern era of the wave of globalization, financial development is leading toward a higher rate of economic expansion and promoting energy innovation around the globe. Nevertheless, environmental impact of financial development has preoccupied government officials to circumvent adverse impact on environmental quality. Thus, this paper examines the nexus between financial development, economic growth, energy innovation, and environmental pollution for the period of 1990–2017 for the panel of Organization for Economic Cooperation and Development (OECD) countries. To obtain robust and unbiased results, this study utilizes Pooled Mean Group Autoregressive Distributed Lag (PMG/ARDL) estimator that counters the issue of heterogeneity and cross‐sectional dependence. Empirical evidence suggests that financial development promotes energy innovation and improves environmental quality. Globalization also has a long‐term relationship with energy innovation and reduces greenhouse gas (GHG) emissions. Moreover, findings validate the environmental Kuznets curve for OECD countries in the significance of financial development, globalization, and energy innovation.
Effect of shaking speed on immobilization of cephalosporin C acylase: Correlation between protein distribution and properties of the immobilized enzymes
Authors: Liu Jingran , Tong Shuangming , Sun Hongxu , Chang Yanhong , Luo Hui , Yu Huimin , Shen Zhongyao 
Published: August 2020

AbstractDuring enzyme immobilization, enzyme activity and protein distribution are affected by various factors such as enzyme load, temperature, and pH. In general, two types of protein distribution patterns (heterogeneous or homogeneous) are observed inside a porous carrier, owing to differences in preparation parameters. During the immobilization of a fusion protein (CCApH) of cephalosporin C acylase (CCA) and pHluorin (a pH‐sensitive mutant of green fluorescent protein), different shaking speeds induced obvious differences in protein distribution on an epoxy carrier, LX‐1000EPC. Enzyme immobilization with a homogeneous distribution pattern was observed at a low shaking speed (120 rpm) with an operational stability of 10 batches at 37°C. The operational stability of an immobilisate with heterogeneous protein distribution prepared at a high shaking speed (200 rpm) was six batches. Given the pH‐sensitive characteristics of pHluorin in the fusion protein, the intraparticle pH of CCApH immobilisates during catalysis was monitored using confocal laser scanning microscopy. The microenvironmental pH of the immobilisate with heterogeneous protein distribution sharply decreased by about 2 units; this decrease in the pH may be detrimental to the life‐span of immobilized CCA. Thus, this work demonstrates the good operational stability of pH‐sensitive proton‐forming immobilized enzymes with homogeneous protein distribution.
From corporate environmental responsibility to purchase intention of Chinese buyers: The mediation role of relationship quality
Authors: Xu Mingze , Lai Ivan Ka Wai , Tang Huajun 
Published: August 2020

AbstractDeteriorating environmental conditions and frequent environmental incidents have urged corporations' execution on corporate environmental responsibility (CER). For maintaining a positive CER, buyers have considered the performance of their suppliers' CER when the buyers plan to sign or renew a contract with their suppliers. However, it is still under‐examined how the mechanism works between supplier CER and buyer repurchase intention (BRPI). This study explores the mediating effects of relationship quality between supplier CER and BRPI. Based on 209 samples of Chinese buyers, the results show that supplier CER has a significant direct effect on buyer satisfaction and trust (the two components of relationship quality), and the relationship quality mediates the effects of supplier CER on the BRPI. This study provides insights into relationship marketing through crosslink CER with the relationship quality theory to explain the mechanism of how supplier CER benefits buyer purchase intention.
Outcomes following endovascular therapy for acute stroke by interventional cardiologists
Authors: Bob‐Manuel Tamunoinemi , Hornung Marius , Guidera Steven , Prince Marloe , Duran Antonio , Sievert Horst , Bertog Stefan , Grunwald Iris , White Christopher J. 
Published: August 2020

AbstractObjectivesTo summarize the outcomes of acute ischemic stroke (AIS) intervention by interventional cardiologists (IC) working on a stroke team.BackgroundThere is a geographic maldistribution of dedicated neuro‐interventionalists (NI) to treat large vessel occlusion (LVO) AIS.MethodsResults of 166 consecutive patients who received endovascular therapy (EVT) for AIS due to LVO by IC at three centers between 2009 and 2019 are reported. A modified Rankin score (mRs) of ≤ 2 at 90 days after EVT was used as the primary measurement of a good neurological outcome. Univariate logistic regression was used to evaluate predictors of the mRS > 2 and mortality. Those variables with significance of p < .2 from the univariate analysis were included in a multivariate analysis.ResultsAll‐cause mortality at 30 days was 22%. A favorable clinical outcome, mRS ≤ 2 at 90 days, was 49%. After multivariate analysis and controlling for confounders, a higher baseline NIHSS was predictive of 30‐day mortality (OR 1.20 [95% CI 1.09–1.32] p < .001) and unfavorable clinical outcome (mRS > 2) at 90 days (OR 1.16 [95% CI 1.07–1.25] p < .001).ConclusionOutcomes for carotid stent capable IC performing EVT for AIS are comparable to those achieved by NI physicians in major randomized clinical trials. Our data supports conducting a clinical trial of carotid stent capable IC working on multidisciplinary stroke teams to perform EVT for AIS due to LVO in communities and hospitals without timely access (<60 min by ground transport) to dedicated NI.
Waxy wheat extrusion: Impacts of twin‐screw extrusion on hard red waxy wheat flour
Authors: Kowalski Ryan J. , Gu Bon‐Jae , Hause Jacob P. , Pietrysiak Ewa , Dhumal Gaurav , Campbell Henry , Ganjyal Girish M. 
Published: August 2020

AbstractBackground and objectivesTwo varieties of hard red spring waxy wheat were extruded with varying barrel temperatures, screw speeds, feed moistures, and screw profiles to determine their extrusion processing characteristics. A nonwaxy control wheat was also extruded to examine differences that occur in the extrusion of waxy wheat.FindingsIt was found that radial expansion ratios of waxy wheat were approximately 4.5 with specific conditions and were similar to expansion ratios obtained from nonwaxy wheat. However, specific mechanical energy requirements for nonwaxy wheat far exceeded both of the waxy wheat varieties to produce this expansion. In doing so, the nonwaxy wheat also produced extrusion pressures that were nearly double that of pressures generated from waxy wheat.ConclusionsThe results demonstrated that hard red waxy wheat may offer a low‐energy extrusion alternative to conventional wheat flour extrusion.Significance and noveltyThis study highlights the differences in the processing energy consumption between hard red waxy wheat and nonwaxy wheat. The results demonstrate that waxy wheat may offer lower operational costs for extrusion and presents excellent potential in the development of new consumer food products.
Superior gluteal nerve injury following landmark‐guided corticosteroid injection for greater trochanteric pain: A case report
Authors: Thompson Austin R. , Ensrud Erik R. 
Published: August 2020

AbstractThis report describes an isolated superior gluteal nerve injection injury following a corticosteroid injection for greater trochanteric pain syndrome. Ultrasound‐guided injections may be beneficial to target multiple pain‐producing regions of the hip while avoiding nerves and tendons.
White lung with milky effusion
Authors: Zaalouk Tamer Mohamed , Bitar Zouheir Ibrahim , Maadarani Ossama Sajeh , El‐shably ALAsmar Mohammed 
Published: August 2020

AbstractThoracic duct injury is a rare complication of dorsal spine operations. Ultrasound chest plays an important tool for rapid diagnosis of acute dyspnea, drainage of massive effusion, and daily follow‐up. Conservative treatment of postoperative chylous with measures to decrease chylous formation can lead to a resolution of chylothorax.
Evisceration of umbilical content with extensive adhesion: A surgical approach
Authors: Mishra Pravin , Yadav Vivek Kumar , Hasan Moinul 
Published: August 2020

AbstractWith timely recognition and surgical intervention along with administration of an antibiotic, antihistaminic, and anti‐inflammatory drugs, evisceration of umbilical content with extensive adhesion can be treated, and the outcome is also good.
Trimethoprim‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with reactivation of human herpes virus‐6 (HHV‐6) leading to acute liver failure
Authors: Subhani Mohsan , Dong Victor , Connolly Aveen , Salisbury Jonathan , Miquel Rosa , Walsh Sarah , Pirani Tasneem 
Published: August 2020

AbstractDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome can have insidious symptoms which may lead to acute liver failure and death. Prompt recognition, stopping offending drug, and initiating corticosteroid are the mainstay of treatment. Early involvement of a specialist liver unit is vital.