bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polycomplex Carrier for Buccal Mucoadhesion Delivery of Metronidazole
Authors: Moustafine R. I. , Budnikov V. V. , Abdullina S. G. , Nasibullin Sh. F. , Saleev R. A. 
Published: May 2020

Introduction. One of the well-known requirements for buccal drug delivery systems is the demonstration of mucoadhesive properties of the carrier, ensuring retention on the mucosa for a long time with the gradual release of the included drug. It should be noted that one of the advantages of buccal systems compared with oral ones is the absence of the «first pass effect» through the liver.Aim. To carry out a physicochemical and pharmaceutical research of the interpolyelectrolyte complex (IPEC), obtained on the basis of pharmaceutically acceptable polymers – Eudragit® EPO and Noveon® AA-1, in comparison with the physical mixture and individual polymers, as a mucoadhesive delivery system of metronidazole for the treatment of periodontal diseases.Materials and methods. Obtained on the basis of a pair of pharmaceutical polymers (Eudragit® EPO and Noveon® AA-1), two IPEC samples were characterized by elemental analysis, FTIR spectroscopy, and modulated temperature differential scanning calorimetry (mDSC) in comparison with individual polymers and their physical mixtures. The study of swelling ability, bioadhesion and release was carried out in a medium simulating artificial salivary fluid (pH 7.0) at a temperature of 37 ± 0.1 °C. Mucoadhesion of polymer samples and IPEC was studied using a TA.XTplus texture analyzer (Stable Micro Systems, UK). The release of metronidazole (MD) from matrices based on the developed IPEC was studied on a CE 7Smart USP 4 apparatus (Sotax, Switzerland) using the Flow Trough Cell method at a speed a flow of 20 ml/min in an open cycle within 5 hours. The amount of released MD was estimated by UV spectrophotometry on a Lambda 25 instrument (PerkinElmer, USA) at a wavelength of 319 nm.Results and discussion. As a result of studies on the physicochemical and pharmaceutical properties, there was selected the optimal composition of a polycomplex carrier (IPEC 2) based on Eudragit® EPO and Noveon® AA-1, which is characterized by the required bioadhesive properties and the ability of providing controlled release of drug from the tablet matrix (with weight ratio MD/IPEC-2 1:0.5) in conditions mimicking oral cavity environment, which provides the necessary mode of buccal delivery of metronidazole in accordance with Fick's law of diffusion.Conclusion. IPEC 2 is a perspective for use as carrier for buccal controlled delivery of metronidazole.
Quantitative Determination of Naltrexone Hydrochloride in a Nasal Spray by High-performance Liquid Chromatography
Authors: Domnina Yu. M. , Suslov V. V. , Kedik S. A. , Vorfolomeeva E. V. , Meleshko A. V. 
Published: May 2020

Introduction. Naltrexone, an antagonist of µ-opioid receptors, is promising for the treatment of various autoimmune and oncological diseases when used in doses of 1.5–5 mg/day. To date, there are no medications that provide such dosages of naltrexone.Aim. Development and validation of a method for the quantitative determination of naltrexone hydrochloride in a nasal spray by high performance liquid chromatography (HPLC).Materials and methods. As an object of research, a naltrexone hydrochloride nasal spray was used. The quantitative determination of naltrexone in the test sample was developed using a Dionex UltiMate 3000 high-performance liquid chromatograph (Thermo Scientific, USA) equipped with a diode-matrix detector.Results and discussion. The possibility of using isocratic and gradient chromatographic modes for the quantitative determination of naltrexone hydrochloride in the nasal spray was studied. Based on these results, a new method of determination using the gradient mode is proposed, which allows minimizing the influence of the polymer component in the test sample on the analysis results.Conclusion. A new technique of high-performance liquid chromatography (HPLC) is proposed that allows identification and quantification of naltrexone hydrochloride in a nasal spray containing a high concentration of water-soluble heat-sensitive poloxamer as a thickener. The developed method was validated according to the parameters: correctness, precision, specificity, linearity.
Helmuth Plessner's Social and Political Thought in Light of his Philosophy of Life
Authors: Chrobak Karol 
Published: May 2020

The essay contains an analysis of selected socio-political ideas of Helmuth Plessner. The basic assumption of this study is the existence of a close categorial relationship between Plessner’s reflections in The Limits of Community (1924) and in Die Stufen des Organischen (1928). As the interpretative key, the author uses one of the pivotal concepts of Plessner’s philosophy of life, namely the category of “border.” Showing the adequacy of this category in relation to Plessner’s social and political concepts, the essay addresses the issue of the individual-society relationship, the question of social roles and their possible deviations, and the problem of political leadership.
Effect of Herringbone Technique on Studentsâ€™ Reading Comprehension through Narrative Text at MTs PAB 1 Helvetia, Medan
Authors: Losi Rizky Vita 
Published: May 2020

The Effect of Herringbone Technique on Studentsâ€™
Reading Comprehension through Narrative Text
at MTs PAB 1 Helvetia, Medan

Rizky Vita Losi
Universitas Pembangunan Panca Budi
rizkyvitalosi@pancabudi.ac.id

Abstract
This research dealt with Herringbone technique which was proposed by Deegan (2006). The aim of this research was to know whether Herringbone technique was effective to be applied on studentsâ€™ reading comprehension through narrative text. The sample of this research was grade VIII-E students which consisted of 31 students at MTs PAB 1 Helvetia, Medan. The data of this research was studentsâ€™ reading comprehension score on pre-test and post-test. The data was analyzed by using Paired Sample T-Test formula which was calculated by SPSS 2.2. From the data analysis, it was found that the T-Test value was higher than the T-Table value (10,085 > 2,042). It showed that the alternative hypothesis (Ha) was accepted and the null hypothesis (Ho) was rejected. It also showed that there was a significance effect after applying Herringbone technique on studentsâ€™ reading comprehension through narrative text at MTs PAB 1 Helvetia, Medan.

Keywords: herringbone technique, studentsâ€™ reading comprehension, paired sample t-test formula
Peningkatan Pemahaman Tentang Politik Uang Bagi Pemilih Pemula Di Kecamatan Kuala Pesisir Kabupaten Nagan Raya
Authors: Ilhamsyah Fadhil , Fadhly Zuhrizal , Kabiru Rafiie Said Ahmad , Najamudin Najamudin 
Published: May 2020

This paper explains about innovation of the local government which is part of the Population and Civil Registration (Dukcapil) service reform. Aklamasidansa is the policy of the West Aceh Regency in the matter of arranging birth certificates and death certificates that are integrated with village funds. The issue of legal identity is still a problem in Indonesia, many people do not have a legal identity so that it has an impact on all services provided by the government to the community. Aklamasidansa is an innovation that brings government and society closer. Aklamasidansa has been running since 2017 and operates in the assisted villages. This study used a qualitative method with a case study approach, the informants of this study were the community as recipients of services, the West Aceh government as an innovator. The results of the study show that the aklamasidansa policy has increased the coverage of legal identity ownership, especially birth certificates which increased from 70.25% percent (June 2017) to 93.90 percent (December 2018). Aklamasidansa as one of the service innovations to the community is running very well in improving the data administration of the village and make it easier for citizens to receive services in arranging birth certificates and death certificates.
Jurnalisme Kampus Dan Perkembangan di Era Industri 4.0
Authors: Muzakkir Muzakkir 
Published: May 2020

“Jurnalisme Kampus Dan Perkembangan di Era Industri 4.0”, adalah kajian yang bernilai inovatif dan kreatif dipaparkan untuk memotivasi mahasiswa agar menjiwai jurnalisme. Jurnalisme kampus yang merupakan ranah jurnalistik di era industri 4.0 mempunyai tujuan sebagai sarana mengedukasi mahasiswa dan publik. Jurnalisme kampus jangan sampai dipengaruhi dan terjebak dalam narasi publik yang sarat dengan kepentingan pihak tertentu. Sebagai bagian dari kelompok terdidik, mahasiswa juga harus memiliki kemampuan dalam mengembangkan potensi dalam dirinya. Salah satunya adalah dalam dunia tulis menulis. Mahasiswa harus mengembangkan potensinya semaksimal mungkin, tidak hanya di bidang akademik, tetapi juga harus kreatif dan memiliki semangat inovasi. Mahasiswa adalah orang dapat memberikan perubahan di dalam bermasyarakat. Akhir 2018, Indonesia dikejutkan dengan hadirnya sistim revolusi industry 4.0, dan ini salah satu momok yang sangat menyeramkan dikalangan mahasiswa Indonesia. Karenanya, diperlukan peran mahasiswa mensosialisasikan untuk memberikan pemahaman kepada masyarakat.
Pemasangan Kontrasepsi Implan dan AKDR di Dusun XVIII Kecamatan Percut Sei Tuan
Authors: Simanjuntak Netti Meilani , Siregar Dian Andriyani , Margareth Friska 
Published: May 2020

Angka kelahiran di Indonesia semakin meningkat sehingga kesejahteraan masyarakat rendah. Untuk itu pemerintah mencanangkan program keluarga berencana agar terwujud keluarga berkualitas. Menurut data Badan Pemberdayaan Perempuan dan Keluarga Berencana (BPPKB) tahun 2014 bahwa peserta KB AKDR sebanyak 29.292 (7,7%), implant sebanyak 32.383 (8,5%). Data menunjukkan bahwa kontrasepsi metode jangka panjang kurang diminati oleh wanita usia subur. Hal ini terbukti dari prevalensi kontrasepsi suntik yaitu sebanyak 74.024 (20,2%). Hasil wawancara singkat yang dilakukan kepada wanita usia subur di Dusun XVIII Kecamatan Percut Sei Tuan, menjelaskan bahwa ibu – ibu tersebut takut sakit, jarak yang jauh untuk mengakses pelayanan kesehatan. Dari hasil pendataan yang dilakukan bahwa masih banyak wanita usia subur yang sudah memiliki > 2 anak akan tetapi enggan untuk dilakukan pemasangan kontrasepsi. Hal ini juga dikarenakan kurangnya pengetahuan ibu tentang kontrasepsi jangka panjang. Oleh karena itu penting untuk dilakukan pengabdian kepada masyarakat dengan memberikan edukasi tentang kontrasepsi jangka panjang serta pemasangan AKDR dan Implant pada wanita usia subur di Dusun XVIII Kampung KB Kecamatan Percut Sei Tuan.
Remaja Kreatif-Produktif sebagai Treatment Pencegahan Terhadap Penyalahgunaan Narkoba pada Remaja di Pedesaan
Authors: Nurlian Nurlian , Saputra Akmal , Yana Rahmah Husna 
Published: May 2020

Remaja adalah generasi penerus bangsa yang harus dibangun sisi kreatifitasnya untuk mampu melahirkan produktivitas dalam kehidupannya sehari-hari dan untuk hidup berdampingan dengan masyarakat. Membangun sisi kepribadian remaja kreatif-produktif, secara nyata remaja harus diajuhkan dari narkoba, baik ganja, sabu-sabu dan jenis narkoba laiinya. Narkoba adalah zat kimia yang mampu membunuh kreatifitas remaja selain membunuh mental sisi lainnya serta merusak kesehatannya. Sudah banyak kasus-kasus remaja yang bermasalah setelah mencicipi narkoba, sehingga kondisi seperti itu meresahkan masyarakat dan mengganggu keharmonisan dalam masyarakat. Untuk menyadarkan remaja-remaja tersebut, sosialisasi remahja kreatif-produktif dan anti narkoba harus dilakukan diwilayah pedesaan. Berpikir kreatif dan produktif akan melahirkan banyak manfaat posistif bagi kehidupan remaja dan tidak ada masalah-masalah sosial yang muncul yang disebabkan oleh remaja. Berpikir kreatif-produktif mampu menciptkan perubahan-perubahan yang posistif bagi kehidupan remaja itu sendiri, misalnya, akan melatih remaja untuk mendisplinkan diri, mampu melahirkan ide-ide baru, mampu untuk melakukan hal-hal positif juga, seperti berjualan, menjaga sikap dimasyarakat dan mampu menyusun rencana masa depan yang baik.
The Analysis of Vertical Mismatch and Manufacturing Labor Wage by Using Cramer's V Method
Authors: Hartato Hartato 
Published: May 2020

As the leading sector of the national economy through its contribution, the manufacturing industry sector in Indonesia was precisely filled with the dominance of vertical mismatch or mismatch between education levels and types of work based on the 2015 National Labor Force Survey (Sakernas). The negative effects of vertical mismatch have an impact on the low wages earned by labor because investment at the education level is not maximally used when working. This paper aims to study the tendency of vertical mismatch to labor wages in the manufacturing industry sector by training, education level, region, & generation using descriptive analysis methods (crosstabulation & graphics) and Cramer's V to see the correlation with August 2015 Sakernas data. The results of research with the total sample of 1,259 workers shows that vertical mismatch is significantly related to labor wage with the tendency of workers who are overqualified to face low wages. In addition, overqualified workers occur in all regions of Indonesia with the characteristics of younger generations and Diploma IV / S1 graduates. The conclusion of this paper is that industrial labors in Indonesia are still classified as overqualified and experience low wages. The efforts that need to be done are improving the skills of workers through training so as to have a positive effect on mismatch workers to obtain higher wages.
Deskripsi Kualitatif Terhadap Peran Media TV Swasta Dalam Mensosialisasikan Kandidat Pilwali Di Kota Makassar
Authors: Nur Emil Syah 
Published: May 2020

Abstrak, Media TV sebagai media elektronik bertindak sebagai penyalur informasi seputar Pemilukada maupun sebagai media sosialisasi aktor politik untuk memperoleh dukungan. Meskipun media TV dapat diakses oleh setiap lapisan masyarakat, namun pengetahuan masyarakat terhadap politik maupun kesadaran untuk menggunakan hak pilihnya masih rendah. Penelitian ini adalah penelitian kualitatif menggunakan teknik pengumpulan data wawancara dan observasi. Hasil penelitian menunjukkan peran media televisi dalam mensosialisasikan kandidat calon walikota Makassar menunjukkan bahwa kemampuan untuk memahami dan mengeksploitasi kemungkinan bebagai tawaran dari media massa untuk memproyeksikan profil seseorang sekaligus mencapai serta memanipulasi publik massa. Oleh karena, eksistensi TV swasta dianggap berpotensi untuk mengkonstruksi wajah politik di Kota Makassar.Peran media televisi swasta di Kota Makassar dapat dilihat dari netralitas dalam mensosialisasikan kandidat calon Walikota Makassar dapat dilihat dari netralitas televise dalam menyampaikan visi dan misi. Netralitas media telvisi dalam kapasitas sebagai media sosialisasi tercatat sebagai pendukung pasangan kepala daerah khususnya di Kota Makassar. Konsep netralitas belum mampu mendukung peran televisi dalam mensosialisasikan calon walikota Makassar. Hal ini dapat dilihat dari keberimbangan (balance), ketidakberpihakan (impartiality), keadilan (fairness), dan obyektivitas (objectivity) kurang mampu terlaksana dengan baik.
Broompare in sunflower crops and control methods
Authors: Ivashchenko O. 
Published: May 2020

Goal. The study of the biological characteristics and developing methods for effective control of Broomrape in sunflower crops.
Methods. The comprehensive study included the route survey of crops in the five regions of the country where traditionally the acreage of sunflower is the largest part in the structure of arable land. Was conducted sampling of the soil in the fields to assess the level of contamination by seeds of Broomrape. Repeated the test 4. Surveys and monitoring of the crops was carried out in accordance with the requirements methods of testing and use of pesticides.
Results. Studies show that the presence of 2—7 of Broomrape stalks per 1 m2 of sunflower crops leading to reduced yields of seed cultures by 10—15%. In the presence of 35—40 pieces/m2 of stalks of the parasite reduction reaches 70—85% of the possible yields of crops. Sample survey of crops of sunflower and soil samples from the arable layer (0—30 cm) during the study years (Zaporizhzhia, Dnipropetrovsk, Odesa, etc.) and their analysis for the presence of seeds of Broomrape showed a high level of contamination. In the upper part of the topsoil (0—10 cm) found 124—1160 seeds/m2 seed of the parasite. However, only a 0.012—0.22% of the total quantity present in the soil of seeds of the parasite germinate in the spring as a result of interaction with the roots of the plant opinion. Easier to just hit the Broomrape seedling primary roots of sunflower plants in the juvenile and amatory stages of organogenesis (May — June).
Conclusions. The practice of using resistant against the respective races of Broomrape sunflower hybrids ensures to provide only a temporary and partial positive results. Immune to defeat different races of Broomrape sunflower hybrids there, and to existing sustainable hybrids parasite quickly forms a new more aggressive population. The most effective nowadays are preventive measures which make it possible to obtain high yields of sunflower and not to complicate the phytosanitary situation on arable lands in the future.
Assessment of soil clogging and seed productivity of weeds on poplar black landings
Authors: Remeniuk S. , Smolkova N. 
Published: May 2020

Goal. Determination of soil contamination of plots planted for planting black poplar and evaluation of seed productivity of weeds.
Methods. The level of seed productivity of the weeds was determined by the weighting method in the following sequence. In the experiment, 10 plants of one weed species were cut and manually threshed on a tarpaulin. The purified seeds were weighed and, after determining the mass of 1000 seeds, the average amount (thousand units /plant) of seeds per plant was converted.
Results. The problem with perennial plantations of bioenergy crops is that the plants are grown for 10—15 years in monoculture on the same section of the field. Consequently, large stocks of certain weeds in the soil can significantly affect the growth and development and productivity level of cultivated plants. So, before planting a plantation, it is necessary to assess the clogging of the plots for the presence of problematic weed species, which can potentially breed on black poplar plantings and impede effective plant care. Virtually all arable land is mothballed with a different weed seed bank. Weed seed stocks depend on the direction of use of the plot, the culture of agriculture, the quality of agricultural operations on care, crop rotation, culture, etc. However, two areas with the same seed reserves in the soil are difficult to find, although the percentage of the main weed species may be identical.
Conclusions. Weeds traditionally have high seed productivity and form large seed banks in the arable soil, reaching 1.5—2.0 million units / ha. Bioenergy crops, especially perennial species, are extremely sensitive to weeds in the first year of growing season. Because they form rather modest growths of vegetative mass and can not receive photosynthetically active energy to the soil, and therefore it is important to ensure the purity of the field from weeds during the first year of vegetation.
Specificity of potential contamination of rice checks with weed seeds
Authors: Tsilinko L. 
Published: May 2020

Goal. To analyze the potential level of contamination of arable soil layer weed seeds and to establish the specificity of the changes in such reserves during the vegetation period of crops. The study was performed on rice checks of the Institute of rice of NAAS in the Kherson region in the 2017—2019 biennium.
Methods. Research field, small and laboratory. To determine the factor of seeds and vegetative reproductive organs of weeds in certain soil horizons of rice fields per unit area (pieces/m2) was selected soil samples by the method of A. N. Kiseleva — twice per season, in spring and after harvest of rice. The arable soil was divided into three layers (10 cm each). To determine the viability of seeds used method of staining their tetrazoles. The results were compiled and analyzed.
Results. A comparison of the level of potential contamination between horizons showed the highest number of weed seeds in the horizon of 0—10 cm on average, 16041 pieces/ m2, which is 47.6% of the overall presence of weeds in the soil (33650,2 pieces/ m2). In the soil horizon 10—20 cm the number of weed seeds reached 10489.2 pieces/m2, or 31.2% of the debris of the upper horizon. In the lower horizon of 20—30 cm level of the presence of weed seeds was low — 7119.8 pieces/ m2, which amounts to 21.2% from that of the top horizon of the soil. Among the weed species whose seeds were present in soil samples of the top horizon of 0—10 cm, the largest part was Kuga Astrakhantseva Scirpus mucronatus L. — 59.8%, in another place Boule seeds Kuga razveseloj Scirpus supinus L. — 31.8%, Polygonum Persicaria hydropiper L. percetage — 1004.7 pieces/ m2 (6,3%), chicken millet Echinochloa crus galli L. — 329.1 pieces/m2 (2.1%). Other types were less in the stocks of weed seeds.
Conclusions. During the vegetation period inventory quantities of seeds of change and by autumn are increasing. The largest amplitude value of the stock of weed seeds is manifested in the upper 0—10 cm horizon of the arable layer and reaches to 12.3%. Qualitative and timely implementation of measures to protect rice crops from sowing to the presence of weeds provides a gradual reduction in the volumes of their Bank of seeds in the soil.
Combined effects of pesticides on weedines and seed yield of soybean crops
Authors: Hutianskyi R. 
Published: May 2020

Goal. of my study was to investigate the combined effect of pesticides, including seed dressers, post-emergence herbicides, fungicides, biologicals, and plant growth regulators on weediness and soybean yield in the Eastern Forest-Steppe of Ukraine.
Methods. Field, analytical and statistical.
Results. The weeds in the soybean crops were represented by 15 species. Cockspur (Echinochloa crusgalli (L.) Roem et Schult.), yellow foxtail (Setaria glaua (L.) Beauv.), lamb’s quarters (Chenopodium album L.) and redroot pigweed (Amaranthus retroflexus L.) dominated in the soybean crops. In the controls, the dominant position in the soybean crops (in terms of the wet weight of weeds) was occupied by biennial and annual dicotyledonous weeds (56—57% of the total wet weight of weeds). Annual gramineous weeds (37—42%) and perennial dicotyledonous weeds (2—6%) ranked the second and third most spread species. Pre-sowing treatment of seeds increased the competitiveness of soybean plants against weeds. Herbicide composition Tabezon (2.0 l/ ha) + Formula (6 g/ ha) + surfactant Trend 90 (0.2 l/ ha) (primordial leaves) + Lemur (1.5 l/ ha) (biternate/ triternate leaves) significantly reduced the total number of weeds in the soybean crops by 89% and their wet weight by 97%. There was no evidence of significant effects of post-emergence combinations of herbicides with chemical or biological pesticides on the effectiveness of weed control in the soybean crops. Analyzing the soybean seed yield, I revealed that application of herbicides alone in the crops was the most justified.
Conclusions. Increased competitiveness of soybean plants against weeds on pre-sowing seed treatment has been demonstrated. There was no evidence of significant effects of post-emergence combinations of herbicides with chemical and biological pesticides on the weed control effectiveness. Monoapplication of herbicides was the most justified.