bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report on the long-term survival of a patient with HER2-positive metastatic gastric adenocarcinoma and a short review of the current literature
Authors: Puhr Hannah Christina , Ilhan-Mutlu Aysegül 
Published: September 2020

SummaryThe prognosis of patients with metastatic gastroesophageal cancer remains poor despite numerous promising clinical trials, and the clinical benefit of systemic therapies is under critical review. This case report of a patient with human epidermal growth factor receptor 2 (HER2)-positive metastatic gastric adenocarcinoma is an impulse for the importance of individual decision making and molecular guided treatment options.
Postsynaptic Targeting and Mobility of Membrane Surface-Localized hASIC1a
Authors: Song Xing-Lei , Liu Di-Shi , Qiang Min , Li Qian , Liu Ming-Gang , Li Wei-Guang , Qi Xin , Xu Nan-Jie , Yang Guang , Zhu Michael Xi , Xu Tian-Le 
Published: September 2020

AbstractAcid-sensing ion channels (ASICs), the main H+ receptors in the central nervous system, sense extracellular pH fluctuations and mediate cation influx. ASIC1a, the major subunit responsible for acid-activated current, is widely expressed in brain neurons, where it plays pivotal roles in diverse functions including synaptic transmission and plasticity. However, the underlying molecular mechanisms for these functions remain mysterious. Using extracellular epitope tagging and a novel antibody recognizing the hASIC1a ectodomain, we examined the membrane targeting and dynamic trafficking of hASIC1a in cultured cortical neurons. Surface hASIC1a was distributed throughout somata and dendrites, clustered in spine heads, and co-localized with postsynaptic markers. By extracellular pHluorin tagging and fluorescence recovery after photobleaching, we detected movement of hASIC1a in synaptic spine heads. Single-particle tracking along with use of the anti-hASIC1a ectodomain antibody revealed long-distance migration and local movement of surface hASIC1a puncta on dendrites. Importantly, enhancing synaptic activity with brain-derived neurotrophic factor accelerated the trafficking and lateral mobility of hASIC1a. With this newly-developed toolbox, our data demonstrate the synaptic location and high dynamics of functionally-relevant hASIC1a on the surface of excitatory synapses, supporting its involvement in synaptic functions.
Robotic System for Physical Training of Older Adults
Authors: Avioz-Sarig Omri , Olatunji Samuel , Sarne-Fleischmann Vardit , Edan Yael 
Published: September 2020

AbstractPhysical exercise has many physical, psychological and social health benefits leading to improved life quality. This paper presents a robotic system developed as a personal coach for older adults aiming to motivate older adults to participate in physical activities. The robot instructs the participants, demonstrates the exercises and provides real-time corrective and positive feedback according to the participant’s performance as monitored by an RGB-D camera. Two robotic systems based on two different humanoid robots (Nao, toy-like and Poppy, mechanical-like) were developed and implemented using the Python programming language. Experimental studies with 32 older adults were conducted, to determine the preferable mode and timing of the feedback provided to the user to accommodate user preferences, motivate the users and improve their interaction with the system. Additionally, user preferences with regards to the two different humanoid robots used were explored. The results revealed that the system motivated the older adults to engage more in physical exercises. The type and timing of feedback influenced this engagement. Most of these older adults also perceived the system as very useful, easy to use, had a positive attitude towards the system and noted their intention to use it. Most users preferred the more mechanical looking robot (Poppy) over the toy-like robot (Nao).
Adaptionshandlungen von Multiplikatorinnen und Multiplikatoren zur frühen mathematischen Bildung – Beschreibung und Bewertung aus fachbezogener Perspektive
Authors: Bruns Julia , Schopferer Theresa , Gasteiger Hedwig 
Published: September 2020

ZusammenfassungDie Implementation früher mathematischer Bildung in Kindertagesstätten kann durch fachdidaktische Fortbildungen für frühpädagogische Fachkräfte unterstützt werden. Um Fachkräfte in der Breite zu erreichen, erscheint ein scaling up Ansatz geeignet, bei dem aufbauend auf das FortbildungskonzeptEmMa – Erzieherinnen und Erzieher machen MathematikMultiplikatorinnen und Multiplikatoren qualifiziert werden. Dabei ergibt sich die Herausforderung, dass Fortbildende im Elementarbereich kaum mathematisches und mathematikdidaktisches Wissen mitbringen. Der Kontext dieser Studie ist der scaling up Prozess der FortbildungEmMaunter diesen Umständen. Das Erkenntnisinteresse liegt in der Beschreibung und Bewertung der Adaptionshandlungen der Multiplikatorinnen und Multiplikatoren. Für die Bewertung der Adaptionen werden zwei Kriterien herangezogen: (1) das Kriterium der Präzision, das die Vollständigkeit und Klarheit der Inhalte umfasst und (2) das Kriterium der fachlichen Korrektheit, das durch das Ausbleiben fachbezogener Fehler beschrieben wird. Analysiert werden dabei die theoretischen, fachbezogenen Phasen der von Multiplikatorinnen und Multiplikatoren durchgeführten Fortbildung zur frühen mathematischen Bildung, da davon ausgegangen wird, dass insbesondere diese theoretischen Inhalte für diese Gruppe von Multiplikatorinnen und Multiplikatoren eine Herausforderung darstellen. Zur Untersuchung wurde eine videogestützte, qualitative Feldstudie mitN = 8 Fällen durchgeführt. Mit Hilfe der qualitativen Inhaltsanalyse wurden die Adaptionshandlungen der Multiplikatorinnen und Multiplikatoren charakterisiert und hinsichtlich ihrer Präzision und der fachlichen Fehler in diesen Adaptionen analysiert. Dabei zeigte sich, dass der eigenständige Umgang mit den mathematischen und mathematikdidaktischen Inhalten des FortbildungskonzeptsEmMatrotz intensiver Unterstützung anspruchsvoll und bei vielen Multiplikatorinnen und Multiplikatoren mit fachbezogenen Fehlern verbunden ist. Implikationen dieser Ergebnisse für die weitere Forschung werden diskutiert.
Symbiotic interactions between chickpea (Cicer arietinum L.) genotypes and Mesorhizobium strains
Authors: Gunnabo A. H. , van Heerwaarden J. , Geurts R. , Wolde-meskel E. , Degefu T. , Giller K. E. 
Published: September 2020

AbstractLegume genotype (GL) x rhizobium genotype (GR) interaction in chickpea was studied using a genetically diverse set of accessions and rhizobium strains in modified Leonard Jars. A subset of effective GL x GR combinations was subsequently evaluated in a pot experiment to identify combinations of chickpea genotypes and rhizobium strains with stable and superior symbiotic performance. A linear mixed model was employed to analyse the occurrence of GL x GR interaction and an additive main effects and multiplicative interaction (AMMI) model was used to study patterns in the performance of genotype-strain combinations. We found statistically significant interaction in jars in terms of symbiotic effectiveness that was entirely due to the inclusion of one of the genotypes, ICC6263. No interaction was found in a subsequent pot experiment. The presence of two genetic groups (Kabuli and Desi genepools) did not affect interaction with Mesorhizobium strains. With the exception of a negative interaction with genotype ICC6263 in the jar experiment, the type strain Mesorhizobium ciceri LMG 14989 outperformed or equalled other strains on all chickpea genotypes in both jar and pot experiments. Similar to earlier reports in common bean, our results suggest that efforts to find more effective strains may be more rewarding than aiming for identification of superior combinations of strains and genotypes.
Endothelial Glycocalyx-Mediated Intercellular Interactions: Mechanisms and Implications for Atherosclerosis and Cancer Metastasis
Authors: Mensah Solomon A. , Nersesyan Alina A. , Ebong Eno E. 
Published: September 2020

AbstractPurposeThe endothelial glycocalyx (GCX) plays a critical role in the health of the vascular system. Degradation of the GCX has been implicated in the onset of diseases like atherosclerosis and cancer because it disrupts endothelial cell (EC) function that is meant to protect from atherosclerosis and cancer. Examples of such EC function include interendothelial cell communication via gap junctions and receptor-mediated interactions between endothelial and tumor cells. This review focuses on GCX-dependent regulation of these intercellular interactions in healthy and diseased states. The ultimate goal is to build new knowledge that can be applied to developing GCX regeneration strategies that can control intercellular interaction in order to combat the progression of diseases such as atherosclerosis and cancer.MethodsIn vitroandin vivostudies were conducted to determine the baseline expression of GCX in physiologically relevant conditions. Chemical and mechanical GCX degradation approaches were employed to degrade the GCX. The impact of intact versus degraded GCX on intercellular interactions was assessed using cytochemistry, histochemistry, a Lucifer yellow dye transfer assay, and confocal, intravital, and scanning electron microscopy techniques.ResultsRelevant to atherosclerosis, we found that GCX stability determines the expression and functionality of Cx43 in gap junction-mediated EC-to-EC communication. Relevant to cancer metastasis, we found that destabilizing the GCX through either disturbed flow-induced or enzyme induced GCX degradation results in increased E-selectin receptor-mediated EC-tumor cell interactions.ConclusionOur findings lay a foundation for future endothelial GCX-targeted therapy, to control intercellular interactions and limit the progression of atherosclerosis and cancer.
Refractive Index Sensor Based on Metal-Clad Planar Polymer Waveguide Operating at 850 nm
Authors: Ji Lanting , Wei Wei , Li Gang , Yang Shuqing , Fu Yujie , Su Juan , Wu Chi 
Published: September 2020

AbstractA metal-clad planar polymer waveguide refractive index sensor based on epoxy (EPO) polymer materials by using light intensity interrogation at 850 nm is designed. The polymethyl methacrylate (PMMA) material is deployed as the low refractive index (RI) buffer layer in order to better couple the optical guided mode and the surface plasmon polaritons (SPP) mode for working in water environment. The effects of the gold film thickness, PMMA buffer layer thickness, waveguide layer thickness, waveguide width, and gold length on the sensor sensing characteristics have been comprehensively studied. Simulation results demonstrate that the normalized transmission increases quasi-linearly with the increment of RI of the analyte from 1.33 to 1.46. The sensitivity is 491.5 dB/RIU, corresponding to a high RI resolution of 2.6×10−9 RIU. The designed SPP-based optical waveguide sensor is low-cost, wide-range, and high-precision, and has a broad application prospect in biochemical sensing with merits of miniaturization, flexibility, and multiplexing.
“Organismic” positions in early German-speaking ecology and its (almost) forgotten dissidents
Authors: Jax Kurt 
Published: September 2020

AbstractIn early German ecology, the key concept used to refer to a synecological unit wasBiozönose(biocoenosis). Taken together with the concept of theBiotop(biotope), it was also understood as an integrated higher-order unit of life, sometimes called a “Holozön” (holocoen). These units were often perceived as having properties similar to those of individual organisms, and they informed the mainstream of German ecology until at least the late 1960s. Here I ask how “organismic” these concepts really were and what conceptual problems they entailed. To do so, I focus on some almost forgotten dissident positions, especially those of (German-born) Friedrich Simon Bodenheimer and Fritz Peus, which I contrast with the mainstream German ecology of the time. In a radical paper published in 1954 that postulated the “dissolution of the concepts of biocoenosis and biotope”, Peus in particular elicited a forceful response from many prominent German ecologists. An analysis of the ensuing debate, including especially a colloquium held in 1959 that was partly inspired by Peus’ paper, is helpful for sifting the various arguments proffered with respect to a quasi-organismic perception of the biocoenosis in German speaking ecology. Although German mainstream ecologists rejected the notion of the biocoenosis as a superorganism, ontological holism was quite common among them. Additionally, the mainstream concept of the biocoenosis was plagued by several methodological problems and much conceptual confusion, to which the “dissidents” rightly pointed. Some of these problems are still pertinent today, e.g. in connection with more modern concepts such as “ecosystem”.
Analysis of biogeochemical processes in plastic-covered soil during establishment period in strawberry cultivation
Authors: Meyer M. , Diehl D. , Schaumann G. E. , Muñoz K. 
Published: September 2020

AbstractPlastic mulching (PM) has become a widely applied agricultural practice to optimize plant growth. However, it is still under debate how PM influences biogeochemical soil processes and thus important factors of soil quality, such as soil organic matter (SOM) composition, aggregate stability and microbial biomass. Our objective was to identify the impact of PM on biogeochemical soil processes. Therefore, we compared a plastic-covered strawberry cultivation system (PC) with an uncovered system (NC) in three soil layers (0–10, 10–30 and 30–60 cm) at three dates during a 4-month period of strawberry establishment from their transplanting in summer to the beginning of winter. The PC shifted the microclimate of the soil towards higher temperatures but lower moistures in the 0–35 cm soil layer compared to uncovered soil. Predominantly in the surface layer, the PC reduces leaching processes, which can improve nutrient (fertilizer) use efficiency. PC increased SOM and shifted SOM to a more stable SOM. The higher SOM under PC despite larger microbial biomass and elevated temperatures, indicate that belowground biomass inputs compensate the potential SOM losses by an enhanced SOM decomposition under PC. We demonstrated that PC influenced soil processes already within the 4-month period of strawberry establishment, partially down to the 30–60 soil layer. Further, long-term studies are required to estimate the influence of multi-annual PM application on biogeochemical soil processes and on soil quality.
The paradox of prevention in the Women, Peace and Security agenda
Authors: Shepherd Laura J. 
Published: September 2020

AbstractPrevention is a central pillar of the ‘Women, Peace and Security’ agenda, a policy architecture governing gender and conflict that is anchored in a suite of United Nations Security Council resolutions adopted under the title of ‘Women and Peace and Security’. In this article, I argue that prevention is currently constituted within the WPS agenda in multiple ways, all of which are organised in accordance with different logics: a logic of peace; a logic of militarism; and a logic of security. This presents prevention as a paradox, because in operation it collapses back into a logic of security, even as it is constructed and positioned as security's temporal and conceptual other. I provide a close reading of the WPS resolutions and show how the articulations of prevention across the agenda, and in certain resolutions, operate according to logics of security and militarism. The significance of such an argument is twofold: it lies both in the possibility of reconstruction of prevention in the WPS agenda according to different logics, and in the potential of undoing security – as the manifestation of prevention in practice – in queer, feminist, decolonial, and posthuman ways of knowing and encountering the world.
The “terra firma” anecdote: On the attempt to deceive Roald Amundsen during the meeting between the Fram and Terra Nova expeditions in 1911
Authors: Lantz Björn 
Published: September 2020

Abstract
This paper discusses an unsourced anecdote in Roland Huntford’s dual biography of Scott and Amundsen and their race for the South Pole; the first edition of the book was published in 1979. During a meeting between the Fram and Terra Nova in the Bay of Whales on 4 February 1911, Lieutenant Victor Campbell allegedly told Roald Amundsen—in order to deceive him—that one of the British motor sledges was “already on terra firma”. In a recent article in Polar Record, Huntford received criticism for (seemingly) having imagined the episode. However, a description of this incident, though with a slight variation compared to Huntford’s version, can be found in Tryggve Gran’s book, Kampen om Sydpolen [The Battle for the South Pole], published in 1961. Hence, one must conclude that Campbell really did try to mislead Amundsen regarding the motor sledges. Nevertheless, it is unlikely that the attempted deception had an impact on Amundsen’s plan for his south polar journey.
A Pilot Study using the Compensatory Reserve Index to evaluate individuals with Postural Orthostatic Tachycardia syndrome
Authors: Shahi Niti , Shirek Gabrielle , Pickett Kaci , Schwartz Alexandra , Shoop Jamie , Phillips Ryan , Workman Rachel , Kaplan David , Pitula Clio , Moulton Steven 
Published: September 2020

AbstractPurpose:The diagnosis of Postural Orthostatic Tachycardia syndrome traditionally involves orthostatic vitals evaluation. The Compensatory Reserve Index is a non-invasive, FDA-cleared algorithm that analyses photoplethysmogram waveforms in real time to trend subtle waveform features associated with varying degrees of central volume loss, from normovolemia to decompensation. We hypothesised that patients who met physiologic criteria for Postural Orthostatic Tachycardia syndrome would have greater changes in Compensatory Reserve Index with orthostatic vitals.Methods:Orthostatic vitals and Compensatory Reserve Index values were assessed in individuals previously diagnosed with Postural Orthostatic Tachycardia syndrome and healthy controls aged 12–21 years. Adolescents were grouped for comparison based on whether they met heart rate criteria for Postural Orthostatic Tachycardia syndrome (physiologic Postural Orthostatic Tachycardia syndrome).Results:Sixty-one patients were included. Eighteen percent of patients with an existing Postural Orthostatic Tachycardia syndrome diagnosis met heart rate criteria, and these patients had significantly greater supine to standing change in Compensatory Reserve Index (0.67 vs. 0.51; p<0.001). The optimal change in Compensatory Reserve Index for physiologic Postural Orthostatic Tachycardia syndrome was 0.60. Patients with physiologic Postural Orthostatic Tachycardia syndrome were more likely to report previous diagnoses of anxiety or depression (p = 0.054, 0.042).Conclusion:An accurate diagnosis of Postural Orthostatic Tachycardia syndrome may be confounded by related comorbidities. Only 18% (8/44) of previously diagnosed Postural Orthostatic Tachycardia syndrome patients met heart rate criteria. Findings support the utility of objective physiologic measures, such as the Compensatory Reserve Index, to more accurately identify patients with true autonomic dysfunction.
Feasibility and diagnostic performance of including point-of-care ultrasound (POCUS) in preparticipation screening of young competitive athletes
Authors: Fabregat-Andrés Óscar , Pina-Buded Santiago , Valverde-Navarro Alfonso Amador 
Published: September 2020

AbstractOptimal pre-participative screening in young athletes is still controversial. We sought to evaluate the strategy of including point-of-care ultrasound to electrocardiogram. In total, 1188 young competitive athletes were screened in different sports institutions. This proved to be a useful strategy by improving diagnostic performance primarily with respect to detect structural abnormalities and also by minimising positive false cases of electrocardiogram alone.
Bifurcations at the Stability Transition of Earthquake Faulting
Authors: Mele Veedu Deepa , Giorgetti Carolina , Scuderi Marco , Barbot Sylvain , Marone Chris , Collettini Cristiano 
Published: September 2020

AbstractTectonic faults typically break in a single rupture mode within the range of styles from slow slip to dynamic earthquake failure. However, in increasingly well‐documented instances, the same fault segment fails in both slow and fast modes within a short period, as in the sequences that culminated in the 2011 Mw = 9.0 Tohoku‐Oki, Japan, and 2014 Mw = 8.2 Iquique, Chile, earthquakes. Why slow slip alternates with dynamic rupture in certain regions but not in others is not well understood. Here, we integrate laboratory experiments and numerical simulations to investigate the physical conditions leading to cycles where the two rupture styles alternate. We show that a bifurcation takes place near the stability transition with sequences encompassing various rupture modes under constant loading rate. The range of frictional instabilities and slip cycles identified in this study represents important end‐members to understand the interaction of slow and fast slip on the same fault segment.
Temporal Modulation of the Local Microseism in the North Sea
Authors: Becker D. , Cristiano L. , Peikert J. , Kruse T. , Dethof F. , Hadziioannou C. , Meier T. 
Published: September 2020

AbstractPrimary and secondary microseism originating in the world oceans and peaking at around 14 and 7 s, respectively, characterize the Earth's background noise in that frequency range. Microseism generated in marginal seas with partly shorter periods and higher spatial and temporal variability is less studied and requires stations in immediate proximity to the source to be observed. Such studies can help to elucidate the exact microseism generation areas and mechanisms in a constrained area. We analyze 15 years of broadband data recorded at the seismic station on Helgoland island in the marginal North Sea. In addition to remote primary (RPM) and secondary microseism (RSM) originating in the North Atlantic, we observe strong and dominant local secondary microseism (LSM) with on average higher frequencies above 0.2 Hz, in accordance with shorter wave periods of about 4–8 s in the shallow North Sea. During times with low RSM activity we observe local primary microseism (LPM) at frequencies in agreement with local ocean wave periods. The higher horizontal to vertical (H/V) ratio of LPM with respect to LSM indicates a major non‐Rayleigh wave contribution. LSM and LPM show a strong modulation with local semidiurnal ocean tides and microseism energy maxima preceding the water level maximum by 2.5 and 1.5 hr, respectively. This time shift might be influenced by stronger currents during rising than falling tides. Active sources of tide‐modulated microseism migrate along the North Sea coast in sync with the ocean tidal signal as evidenced by comparison of LSM maxima at stations distributed along the coast.