bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the housing market dynamics and its fundamentals: new evidence from Cyprus
Authors: Alola Andrew Adewale 
Published: February 2020

PurposeStudies have shown that economic expansion is characterized by the activities in the productive and industrial sectors. And, recently, the Republic of Cyprus has consistently experienced a relative economic growth. In this light, the current study revisits the dynamics of the housing market and its fundamentals for Cyprus using the quarterly data from 2005Q1 to 2016Q4.Design/methodology/approachProducer price and industrial production indices were employed along with the gross domestic product per capita and urban population as control variables. The empirical technique employed is the dynamic and fully modified ordinary least square approaches where unobserved factors are potentially controlled.FindingsEmpirical evidence of long-run relationship exists between the observed indicators and the house price. Indicatively, statistical evidence reveals a positive and significant long-run relationship between the producer price index and the house price. In a similar manner, there is a strongly significant but a negative long-run nexus of industrial production index and the house price. And, expectedly, the observed long-run nexus of the house price and each of real gross domestic product per capita and the urban population is positive and significant. Interestingly, there exists significant unidirectional Granger causality from each of the independent variables to the housing price. Lastly, the robustness check and the diagnostic test of the investigation suggest a very consistent result and stable model with no problems of serial correlation and heteroskedasticity.Research limitations/implicationsThe fragility of Cyprus's housing market suggests the need for the adoption of an effective policy framework.Originality/valueAlthough the housing market has been studied in the context of the Republic of Cyprus, the novelty is hinged on the joint incorporation of the industrial and producer price indices in a housing model of the study.
Commentary on “Diabetes and people with learning disabilities: issues for policy, practice and education”
Authors: Redquest Brianne , Lunsky Yona 
Published: February 2020

Purpose
There has been an increase in research exploring the area of intellectual and developmental disabilities (IDD) and diabetes. Despite being described as instrumental to diabetes care for people with IDD, the role and experiences of family carers, such as parents and siblings, are often neglected in this research. However, it is clear that family carers do not feel that they have sufficient knowledge about diabetes. The purpose of this commentary is to extend the content from “Diabetes and people with learning disabilities: Issues for policy, practice, and education (Maine et al., 2020)” and discuss how family carers can feel better supported when caring for someone with IDD and diabetes.

Design/methodology/approach
This commentary discusses specific efforts such as STOP diabetes, DESMOND-ID and OK-diabetes for people with IDD including family carers. Encouragement is given for health care providers to recommend such programmes to people with IDD and their family carers. It is also suggested that health care providers involve family carers in diabetes care planning and implementation for people with IDD.

Findings
It is hoped that if changes are made to current diabetes practices and more research with family carers is conducted, diabetes prevention and management for people with IDD will be more successful and family carers can feel more confident in providing support to their loved ones.

Originality/value
Research exploring the role of family carers in diabetes care for people with IDD and diabetes is very limited. This commentary makes recommendations to help family carers feel better supported in their role. It also provides areas for future research.
Congruence between voters and parties: The role of party‐level issue salience
Authors: COSTELLO RORY , TOSHKOV DIMITER , BOS BAREND , KROUWEL ANDRÉ 
Published: February 2020

AbstractThe level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties. We focus on the hypotheses that (1) average proximity between the positions of voters and the party they vote for will be highest on the issues that the party emphasises in the election campaign and that (2) this relationship will be stronger for niche parties. We test these hypotheses using data on the policy preferences of voters, party positions, party attention profiles and salience on concrete policy issues in four countries: The Netherlands, Ireland, Germany and Sweden. Overall, we find that voter–party proximity tends to be higher on issues that the party emphasises. As these are the issues where parties typically have the greatest policy impact, this implies that the quality of representation is highest where it matters most. There is some limited evidence that the positive relationship between issue salience and proximity is stronger for niche parties. In sum, the quality of policy representation varies strongly with party‐level issue salience and to a lesser extent with the type of political party.
Impact of nonphysician providers on spatial accessibility to primary care in Iowa
Authors: Young Sean G. , Gruca Thomas S. , Nelson Gregory C. 
Published: February 2020

AbstractObjectiveTo assess the impact of nonphysician providers on measures of spatial access to primary care in Iowa, a state where physician assistants and advanced practice registered nurses are considered primary care providers.Data Sources2017 Iowa Health Professions Inventory (Carver College of Medicine), and minor civil division (MCD) level population data for Iowa from the American Community Survey.Study DesignWe used a constrained optimization model to probabilistically allocate patient populations to nearby (within a 30‐minute drive) primary care providers. We compared the results (across 10 000 scenarios) using only primary care physicians with those including nonphysician providers (NPPs). We analyze results by rurality and compare findings with current health professional shortage areas.Data Collection/Extraction MethodsPhysicians and NPPs practicing in primary care in 2017 were extracted from the Iowa Health Professions Inventory.Principal FindingsConsidering only primary care physicians, the average unallocated population for primary care was 222 109 (7 percent of Iowa's population). Most of the unallocated population (86 percent) was in rural areas with low population density (< 50/square mile). The addition of NPPs to the primary care workforce reduced unallocated population by 65 percent to 78 252 (2.5 percent of Iowa's population). Despite the majority of NPPs being located in urban areas, most of the improvement in spatial accessibility (78 percent) is associated with sparsely populated rural areas.ConclusionsThe inclusion of nonphysician providers greatly reduces but does not eliminate all areas of inadequate spatial access to primary care.
Garrick and Shakespeare in Europe
Authors: Harriman‐Smith James 
Published: February 2020

This article falls into two parts. In the first I show how David Garrick's performances and responses to them in various media intersected with a particular understanding of Shakespeare's beauties while also projecting across Europe a set of ‘Garrickean' attributes. The second section considers a French and a German translation of Macbeth, the composition and reception of which bear the marks of a Garrickean Shakespeare. Such marking indicates the joint influence of Garrick and Shakespeare outside England, and indicates how celebrity performance, despite the transience of the original events, can be reinscribed through translation and other kinds of international circulation.
Productive Paradoxes: Exploring Prefigurative Practices with Derrida through a Spanish Food Sovereignty Collective
Authors: Gordon Rhyall 
Published: February 2020

AbstractThere has been a proliferation in the use of the concept of prefiguration to describe and understand many of the protest and social change movements of the past decade. However, there are key aspects of the concept that remain unexplored. In this paper I consider telos and justice, and unveil a temporal paradox arising from the thinking behind prefiguration. Rather than this temporal paradox of prefiguration being the undoing of the concept, it does in fact have the potential to be its strength. The purpose of this paper is to assert, by drawing on Derrida’s notion of the impossibility of justice, that the temporal paradox of prefiguration is not something to be resolved but instead is to be foregrounded and navigated. I use research from a food sovereignty collective in the north of Spain to offer an illustration of a prefigurative economic politics that embraces Derrida’s justice‐as‐an‐impossibility.
Letter: infliximab induction regimens in steroid‐refractory acute severe colitis—a propensity score analysis. Authors' reply
Authors: Sebastian Shaji , Myers Sally 
Published: February 2020

LINKED CONTENTThis article is linked to Sebastian et al and Li Wai Suen et al papers. To view these articles, visit https://doi.org/10.1111/apt.15456 and https://doi.org/10.1111/apt.15630.
Bronchospasmolytic activity and adenosine receptor binding of some newer 1,3‐dipropyl‐8‐phenyl substituted xanthine derivatives
Authors: Gumber Divya , Yadav Divya , Yadav Rakesh , Kachler Sonja , Klotz Karl Norbert 
Published: February 2020

AbstractThe aldehyde derivatives of 1,3‐dipropyl xanthines as described in this paper, constitutes a new series of selective adenosine ligands displaying bronchospasmolytic activity. The effect of substitution at third‐ and fourth‐position of 8‐phenyl xanthine has also been taken into consideration. The synthesized compounds showed varying binding affinities at different adenosine receptor subtypes (A1, A2A, A2B, and A3) and also good in vivo bronchospasmolytic activity against histamine aerosol‐induced asthma in guinea pigs. Most of the compounds showed maximum affinity toward the A2A receptor subtype. The monosubstituted 3‐aminoalkoxyl 8‐phenyl xanthine with a aminodiethyl moiety (compound 12e) was found to be most potent A2Aadenosine receptor ligand (Ki = 0.036 µM) followed by disubstituted 4‐aminoalkoxyl‐3‐methoxy‐8‐phenyl xanthine (Ki = 0.050 µM) (compound 10a).
Bank intermediation activity in a low‐interest‐rate environment
Authors: Brei Michael , Borio Claudio , Gambacorta Leonardo 
Published: February 2020

AbstractThis paper investigates how a prolonged period of low‐interest rates affects bank intermediation activity. We use data for 113 large international banks headquartered in 14 major advanced economies during the period 1994–2015. We find that low‐interest rates induce banks to shift their activities from interest‐generating to fee‐related and trading activities. This rebalancing is stronger for low capitalised banks. Banks also moderately adjust their funding structure, away from short‐term market funding towards deposits. We observe a concomitant decline in the risk‐weighted asset ratio and a reduction in loan‐loss provisions, which is consistent with signs of evergreening.
Managing difficult catheterisation in nurse‐led catheterisation services: Does guidewire‐assisted urethral catheterisation make a difference?
Authors: Dragova Mariya , Bamfo Adelaide , Holmes Kevin , Attard Kirk , Frost Anastasia , Mundy Anthony 
Published: February 2020

AbstractThe use of guidewires is well established in medical practice, but relatively new in nurse‐led catheterisation services (NCS). We investigate the incidence of difficult urethral catheterisation and whether guidewire‐assisted catheterisation reduces disrupted patient care. A retrospective Audit (September 2016‐August 2017) recorded incidence and management of difficult catheterisation in two NCS. In NCS‐A, nurses were familiar with improvised guidewire‐assisted catheterisation, whereas in NCS‐B nurses were not enabled and had to refer patients to urologists when they encountered problems. From September 2017 to August 2018, a National Institute for Health and Care Excellence (NICE)‐approved urethral catheterisation device with integrated guidewire (Urethrotech UCD) was used in NCS‐B for difficult urethral catheterisation. User and patient satisfaction was evaluated prospectively. Of 540 men attending NCS‐A for trial without catheter (TWOC), 31% (169/540) were recatheterized, of whom 4%(6/169) required a guidewire‐catheterisation technique to manage difficult catheterisation without problems. This was also done in 45 of 146 men attending for long‐term catheter change with known history of difficult catheter change. Of 1002 men attending NCS‐B for TWOC, 23% (226/1002) were recatheterized. This was difficult in 25% (57/226), of which 40% (23/57) suffered complications with bleeding from repeated catheterisation attempts and 10 men had to be admitted for specialist interventions to manage retention and catheterisation‐associated urethral injury. During the prospective audit, 945 men attended the TWOC‐clinic of NCS‐B. In 11% (13/120), the UCD was used for failed Foley‐catheterisation without complications. Patients and users were very satisfied because the difficult recatheterisation episode was managed successfully without patient harm and care delay. Difficult urethral catheterisation is a frequent occurrence in NCS with significant risk of urethral trauma. Catheterisation‐associated urethral injury can be prevented with guidewire‐assisted urethral catheterisation techniques. The NICE‐approved UCD with integrated guidewire was easy to use with high user and patient satisfaction avoiding patient care delay and is supporting nurses to manage difficult urethral catheterisation safely making efficient use of specialist resources.
Long non‐coding RNA POU6F2‐AS2 promotes cell proliferation and drug resistance in colon cancer by regulating miR‐377/BRD4
Authors: Xu Guangru , Zhu Hongxing , Xu Jinhua , Wang Yan , Zhang Yang , Zhang Minghui , Zhu Dichao 
Published: February 2020

AbstractThe aim of this study was to explore the molecular mechanism of lncRNA POU6F2‐AS2 in proliferation and drug resistance of colon cancer. Total paired 70 colon cancer and adjacent normal tissues were collected from colon cancer patients. Colon cancer and normal colonic epithelial cells were purchased. POU6F2‐AS2 was up‐ or down‐expressed by vectors. LC50 of all cell lines before and after transfection with these plasmids was detected. qRT‐PCR was used to detect the expression of POU6F2‐AS2, miR‐377 and BRD4 before or after transfection. In situ hybridization was also undertaken to detect the level of POU6F2‐AS2. Different concentrations of 5‐Fu (0, 1, 2.5, 5, 10, 20, 40 and 80 μg/mL) were used for 5‐FU insensitivity assay. CCK‐8 and crystal violet staining assay were used for detecting cell proliferation, and flow cytometry was used for identifying cell cycle distribution and apoptosis. In order to detect the fragmented DNA in apoptotic cells, TUNEL assay was used. RNA pull‐down assay and luciferase reporter assay were used to verify the binding site. Rescue assay confirmed the subtractive effect of miR‐377 inhibitors. POU6F2‐AS2 was highly expressed in colon cancer, which was associated with clinical pathology. Up‐regulated POU6F2‐AS2 promoted cell proliferation and cell cycle of colon cancer cells. Overexpression of POU6F2‐AS2 inhibited the expression of miR‐377 and then up‐regulated the expression of BRD4. Up‐regulated BRD4 ultimately promoted cell proliferation and cell survival Down‐regulated POU6F2‐AS2 showed enhanced sensitivity of 5‐FU. POU6F2‐AS2 promoted cell proliferation and drug resistance in colon cancer by regulating miR‐377/BRD4 gene.
Targeting STAT3 enhances NDV‐induced immunogenic cell death in prostate cancer cells
Authors: Wang Xueke , Shao Xiaoyan , Gu Linaer , Jiang Ke , Wang Sitong , Chen Jianhua , Fang Juemin , Guo Xianling , Yuan Min , Shi Ji , Ding Chan , Meng Songshu , Xu Qing 
Published: February 2020

AbstractOncolytic Newcastle disease virus (NDV) induces immunogenic cell death (ICD), liberating danger‐associated molecular patterns (DAMPs) that provokes defiance in neoplastic malignancy. The present study aims to investigate whether and how oncolytic NDV triggers ICD in prostate cancer cells. We show that NDV/FMW, an oncolytic NDV strain FMW, elicited the expression and release of several ICD markers, that is calreticulin (CRT), heat shock proteins (HSP70/90) and high‐mobility group box 1 (HMGB1), in prostate cancer cells. Furthermore, pharmacological repression of apoptosis, necroptosis, autophagy or endoplasmic reticulum (ER) stress exerted diverse effects on the HMGB1 and HSP70/90 evacuation in NDV/FMW‐infected prostate cancer cells. Moreover, ICD markers induced in prostate cancer cells upon NDV/FMW infection, were enhanced by either treatment with a STAT3 (signal transducer and activator of transcription 3) inhibitor or shRNA‐mediated knockdown of STAT3. In nude mice bearing prostate cancer cell‐derived tumours, the tumours injected with the supernatants of NDV/FMW‐infected cells grew smaller than mock‐treated tumours. These results indicate that oncolytic NDV provokes the expression of ICD makers in prostate cancer cells. Our data also suggest that a combination of inhibition of STAT3 with oncolytic NDV could boost NDV‐based anti‐tumour effects against prostate cancer.
Specialized outpatient clinic for deaf and hard‐of‐hearing patients in the Netherlands: Lessons learned in an attempt to improve health care
Authors: Smeijers Anika , van den Bogaerde Beppie , Ens‐Dokkum Martina , Oudesluys‐Murphy Anne Marie 
Published: February 2020

AbstractRationale, aims, and objectiveA group of organizations and individuals in the Netherlands collaborated to attempt to improve access to health care and health education for deaf and hard of hearing (DHH) patients in the country. The outcome was the start of a specialized outpatient clinic named PoliDOSH. An independent research group was set up to evaluate the effect of this specialized clinic. Even though the initiative did not succeed and was closed after 2 years, an extensive analysis of the start‐up and functioning of the whole process was made.MethodsStructured and nonstructured questionnaires and structured interviews.ResultsOnly a small group of DHH patients indicated that they felt a need for consultations at the PoliDOSH. It became clear that to ensure successful functioning of a specialized facility the team members should include a representative group of DHH members. All key functions should be filled by top experts in the relevant fields as well as an expert in communication and needs of the target group.ConclusionsThere is a great need for facilities to collect and disseminate information to and about DHH patients. The information should be aimed at providing psycho‐education for the DHH persons themselves and health care professionals, concerning the specific needs and problems of this patient group. If a similar facility is set up in the future, thorough market research prior to start up is needed to enable the facility to connect with the needs of patients. The start‐up period should allow sufficient time for the project to become known and for patients to become familiar with it and trust it.
Impact of co‐infection with Lepeophtheirus salmonis and Moritella viscosa on inflammatory and immune responses of Atlantic salmon (Salmo salar)
Authors: Carvalho Laura A. , Whyte Shona K. , Braden Laura M. , Purcell Sara L. , Manning Anthony J. , Muckle Anne , Fast Mark D. 
Published: February 2020

AbstractThis study was conducted to determine the effects of a co‐infection with Moritella viscosa at different exposure levels of sea lice Lepeophtheirus salmonis in Atlantic salmon (Salmo salar). M. viscosa (1.14 × 106 cfu/ml) was introduced to all experimental tanks at 10 days post‐lice infection (dpLs). Mean lice counts decreased over time in both the medium lice co‐infection (31.5 ± 19.0 at 7 dpLs; 16.9 ± 9.3 at 46 dpLs) and high lice co‐infection (62.0 ± 10.8 at 7 dpLs; 37.6 ± 11.3 at 46 dpLs). There were significantly higher mortalities and more severe skin lesions in the high lice co‐infected group compared to medium lice co‐infected group or M. viscosa‐only infection. Quantitative gene expression analysis detected a significant upregulation of genes in skin from the high lice co‐infection group consistent with severe inflammation (il‐8, mmp‐9, hep, saa). Skin lesions retrieved throughout the study were positive for M. viscosa growth, but these were rarely located in regions associated with lice. These results suggest that while M. viscosa infection itself may induce skin lesion development in salmon, co‐infection with high numbers of lice can enhance this impact and significantly reduce the ability of these lesions to resolve, resulting in increased mortality.
Mineralized Trichobezoars in a Rhesus Macaque (Macaca mulatta)
Authors: Wilson Jolaine M , Wallace Chelsea K. , Brice Angela K. , Makaron Leah 
Published: February 2020

AbstractA five‐year‐old female rhesus macaque (Macaca mulatta) presented with a thin body condition and multiple palpable mid‐abdominal masses. Mineralized cecal trichobezoars were removed surgically. Thirteen months later, similar masses recurred and were confirmed with radiographs. This is the first case report of a mineralized cecal trichobezoar in a rhesus macaque.
Selective RAR agonists for acne vulgaris: A narrative review
Authors: Kassir Martin , Karagaiah Priyanka , Sonthalia Sidharth , Katsambas Andreas , Galadari Hassan , Gupta Mrinal , Lotti Torello , Wollina Uwe , Abdelmaksoud Ayman , Grabbe Stephan , Goldust Mohamad 
Published: February 2020

AbstractBackgroundAcne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation.AimsThis review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene.MethodsStudies were identified by searching electronic databases (MEDLINE and PubMed) till August 2019 and reference lists of respective articles. Only articles published in English language were included.ResultsTopical retinoids have been first line of treatment for more than 30 years now in treating mild to moderate acne vulgaris. Third generation retinoids like adapalene and tazarotene are selective RAR and γ agonists, having an additional anti‐inflammatory action along with their comedolytic effects and work well in combinations with topical antibiotics, due to the stability of chemical composition.ConclusionTrifarotene is a new 4th generation retinoid with selective action on RAR‐γ receptor alone, which is specific for skin, and it is safe for long‐term maintenance therapy with good efficacy and tolerability.