bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Cellulite Severity Scales and Imaging Methods
Authors: Young V Leroy , DiBernardo Barry E 
Published: August 2020

Abstract
Cellulite is characterized by dimpled contour alterations of the skin and is present in approximately 85% to 90% of postpubertal females. Although the pathophysiology of cellulite remains to be fully elucidated, experimental evidence indicates a multifactorial process involving the number and types of fibrous septae, microvascular dysfunction, subcutaneous inflammation, decreased dermal thickness with age, and fat deposition. Cellulite is a major cosmetic concern for many women, and a number of both noninvasive (eg, massage, cosmeceuticals, laser therapy) and minimally invasive techniques (eg, subcision, collagenase injection) have been evaluated to improve the appearance of the affected skin. However, evidence for many of these treatments is limited, largely due to the lack of a validated, convenient tool for the standardized evaluation of cellulite severity. Various imaging modalities have been employed to characterize cellulite severity and the impact of treatment, but only 2-dimensional and 3-dimensional digital photography have been adequately validated. However, in many cases, imaging findings do not correlate with subjective measures of cellulite severity. A number of cellulite rating scales have been developed; some provide only a qualitative measure, whereas others do not fully capture all clinically relevant aspects of cellulite, including the perspective of the patient. There remains an unmet need for global adoption of a validated scale that can be utilized easily by clinicians and patients in clinical and research settings. We propose features that should be included in an ideal rating scale for assessment of cellulite severity.
Apelin enhances biological functions in lung cancer A549 cells by downregulating exosomal miR-15a-5p
Authors: Ran Jingjing , Li Yan , Liu Lei , Zhu Yihan , Ni Yinyun , Huang Hong , Liu Zhiqiang , Miao Zhiyong , Zhang Li 
Published: August 2020

Abstract
Apelin acts as a tumor promoter in multiple malignant tumors; however, its regulatory mechanism remains unclear. Previous studies have indicated that exosomes are pivotal to mediating tumor progression and metastasis. This study examined whether apelin enhances proliferation and invasion ability of lung cancer cells via exosomal microRNA (miRNA). Lung cancer A549 cells overexpressing apelin and control vector were generated by lentiviral transfection. Exosomes were isolated from the culture supernatant of each cell group and characterized. A-exo and V-exo were, respectively, cocultured with A549 cells, and assays of proliferation, apoptosis, colony formation and invasion were conducted. Exosomal miRNA sequencing (miRNA-seq) was performed on A-exo and V-exo to select a candidate miRNA. It was found that A549 cells absorbed more A-exo than V-exo, and A-exo could promote proliferation, colony formation, migration and invasion of A549 cells more than V-exo. Exosomal miRNA-seq data revealed that miR-15a-5p was markedly lower in A-exo compared with V-exo. Low expression of miR-15a-5p was also found in lung cancer tissues and cell lines, suggesting that miR-15a-5p may have an anti-tumor role. Overexpression of miR-15a-5p in A549 cells was associated with less cell proliferation, migration, invasion and suppressed cell cycle, and lower amounts of CDCA4 (cell division cycle-associated protein 4) indicated that it may be a potential target for miR-15a-5p. This study elucidated a novel regulatory mechanism that apelin may promote proliferation and invasion of lung cancer cells by inhibiting miR-15a-5p encapsulated in exosomes.
Comparison of a Novel Rapid Lateral Flow Assay to Enzyme Immunoassay Results for Early Diagnosis of Coccidioidomycosis
Authors: Donovan Fariba M , Ramadan Ferris A , Khan Sher A , Bhaskara Apoorva , Lainhart William D , Narang Aneesh T , Mosier Jarrod M , Ellingson Katherine D , Bedrick Edward J , Saubolle Michael A , Galgiani John N 
Published: August 2020

Abstract

Background
Coccidioidomycosis (CM) is a common cause of community-acquired pneumonia where CM is endemic. Manifestations include self-limited pulmonary infection, chronic fibrocavitary pulmonary disease, and disseminated coccidioidomycosis. Most infections are identified by serological assays including enzyme-linked immunoassay (EIA), complement fixation, and immunodiffusion. These are time-consuming and take days to result, impeding early diagnosis. A new lateral flow assay (LFA; Sōna; IMMY, Norman, OK) improves time-to-result to 1 hour.

Methods
We prospectively enrolled 392 patients with suspected CM, compared the LFA with standard EIA and included procalcitonin evaluation.

Results
Compared with standard EIA, LFA demonstrates 31% sensitivity (95% confidence interval [CI], 20–44%) and 92% specificity (95% CI, 88–95%). Acute pulmonary disease (74%) was the most common clinical syndrome. Hospitalized patients constituted 75% of subjects, and compared with outpatients, they more frequently had ≥3 previous healthcare facility visits (P = .05), received antibacterials (P &lt; .01), and had &gt;3 antibacterial courses (P &lt; .01). Procalcitonin (PCT) was &lt;0.25 ng/mL in 52 (83%) EIA-positive patients, suggesting infection was not bacterial.

Conclusions
When CM is a possible diagnosis, LFA identified nearly one-third of EIA-positive infections. Combined with PCT &lt;0.25 ng/mL, LFA could reduce unnecessary antibacterial use by 77%.
Potential Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue Viruses
Authors: Lustig Yaniv , Keler Shlomit , Kolodny Rachel , Ben-Tal Nir , Atias-Varon Danit , Shlush Ekaterina , Gerlic Motti , Munitz Ariel , Doolman Ram , Asraf Keren , Shlush Liran I , Vivante Asaf 
Published: August 2020

Abstract

Background
Coronavirus disease 2019 (COVID-19) and dengue fever are difficult to distinguish given shared clinical and laboratory features. Failing to consider COVID-19 due to false-positive dengue serology can have serious implications. We aimed to assess this possible cross-reactivity.

Methods
We analyzed clinical data and serum samples from 55 individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To assess dengue serology status, we used dengue-specific antibodies by means of lateral-flow rapid test, as well as enzyme-linked immunosorbent assay (ELISA). Additionally, we tested SARS-CoV-2 serology status in patients with dengue and performed in-silico protein structural analysis to identify epitope similarities.

Results
Using the dengue lateral-flow rapid test we detected 12 positive cases out of the 55 (21.8%) COVID-19 patients versus zero positive cases in a control group of 70 healthy individuals (P = 2.5E−5). This includes 9 cases of positive immunoglobulin M (IgM), 2 cases of positive immunoglobulin G (IgG), and 1 case of positive IgM as well as IgG antibodies. ELISA testing for dengue was positive in 2 additional subjects using envelope protein directed antibodies. Out of 95 samples obtained from patients diagnosed with dengue before September 2019, SARS-CoV-2 serology targeting the S protein was positive/equivocal in 21 (22%) (16 IgA, 5 IgG) versus 4 positives/equivocal in 102 controls (4%) (P = 1.6E−4). Subsequent in-silico analysis revealed possible similarities between SARS-CoV-2 epitopes in the HR2 domain of the spike protein and the dengue envelope protein.

Conclusions
Our findings support possible cross-reactivity between dengue virus and SARS-CoV-2, which can lead to false-positive dengue serology among COVID-19 patients and vice versa. This can have serious consequences for both patient care and public health.
The strange case of urban theory
Authors: Barnett Clive 
Published: August 2020

Abstract
Recent debates in urban theory have centred on the problem of whether universal concepts can have applications to particular places. These debates could benefit from more serious attention to how urban thought involves styles of analogical reasoning closer in spirit to casuistry than to explanatory theory. The difficult status of ‘the case’ in urban studies is explored through a consideration of different types of universality in this field, leading to a re-consideration of ideas of experimentalism and wicked problems. Further attention should be given to the multiple styles of reasoning through which urban knowledge is produced and circulated.
Microbiomes in a manganese oxide producing ecosystem in the Ytterby mine, Sweden: impact on metal mobility
Authors: Sjöberg Susanne , Stairs Courtney W , Allard Bert , Homa Felix , Martin Tom , Sjöberg Viktor , Ettema Thijs J G , Dupraz Christophe 
Published: August 2020

ABSTRACT
Microbe-mediated precipitation of Mn-oxides enriched in rare earth elements (REE) and other trace elements was discovered in tunnels leading to the main shaft of the Ytterby mine, Sweden. Defining the spatial distribution of microorganisms and elements in this ecosystem provide a better understanding of specific niches and parameters driving the emergence of these communities and associated mineral precipitates. Along with elemental analyses, high-throughput sequencing of the following four subsystems were conducted: (i) water seeping from a rock fracture into the tunnel, (ii) Mn-oxides and associated biofilm; referred to as the Ytterby Black Substance (YBS) biofilm (iii) biofilm forming bubbles on the Mn-oxides; referred to as the bubble biofilm and (iv) fracture water that has passed through the biofilms. Each subsystem hosts a specific collection of microorganisms. Differentially abundant bacteria in the YBS biofilm were identified within the Rhizobiales (e.g. Pedomicrobium), PLTA13 Gammaproteobacteria, Pirellulaceae, Hyphomonadaceae, Blastocatellia and Nitrospira. These taxa, likely driving the Mn-oxide production, were not detected in the fracture water. This biofilm binds Mn, REE and other trace elements in an efficient, dynamic process, as indicated by substantial depletion of these metals from the fracture water as it passes through the Mn deposit zone. Microbe-mediated oxidation of Mn(II) and formation of Mn(III/IV)-oxides can thus have considerable local environmental impact by removing metals from aquatic environments.
Health systems effects of successive emergency health and nutrition projects: an embedded retrospective case study analysis in Sudan and Pakistan
Authors: Sarriot Eric , Olivas Elijah , Khalsa Saraswati , Ashraf Sarah , Hejna Emily , Hinds Givan , Story William T 
Published: August 2020

AbstractDespite increasing attention to the concept of a humanitarian-development nexus in recent years, limited research is available to improve health systems strengthening practice within humanitarian programmes. We used an exploratory, systematic, embedded, multiple case study design to discern systems effects of successive Save the Children chronic emergency health and nutrition projects implemented in Sudan and Pakistan between 2011 and 2018. We used textual analysis to code 63 documents focused on eight themes using NVivo 11.0. This was supplemented by six key informant interviews. Findings offer a complex and mixed picture, with contributions to systems strengthening in community systems, their linkages to health management structures, and human resources for health. Projects with primary mandates for urgent service delivery progressively found systems strengthening opportunities, through a combination of tacit choices and explicit objectives. In both countries, some ‘parallel systems’ were set in place initially, with immediate gains (e.g. quality of services) only occasionally accompanied by enhanced systems capacity to sustain them. Cycles of implementation, however, achieved financial transition of ‘macro-costs’ to the government (e.g. facilities in Sudan, staff in Pakistan) through indirect pathways and the influence of pluralistic governmental structures themselves. Opportunities were taken, or missed, based on dynamic relationships within the government-development partners eco-system. Transition steps also came with unintended effects and drops in intensity. Both project contributions to systems strengthening and our own study were limited by substantial gaps in evaluation and documentation processes. We provide cautious recommendations based on the literature and our two case studies. Even mid-size chronic emergency projects can and should make meaningful and explicit contributions to systems strengthening. This contribution will, however, depend on the development eco-system context, and development of better collective intelligence (coordination, evaluation and learning, benchmarking, accountability) to improve individual projects’ adaptive management efforts to improve fit with evolving national systems.
Effectiveness of a nutrition education and counselling training package on antenatal care: a cluster randomized controlled trial in Addis Ababa
Authors: Omer Afrah Mohammedsanni , Haile Demewoz , Shikur Bilal , Macarayan Erlyn Rachelle , Hagos Seifu 
Published: August 2020

Abstract
The World Health Organization (WHO) recommends the need for a strong nutrition training package for practitioners, including antenatal care (ANC) providers. Without such a training package, ANC visits remain a missed opportunity to address nutritional problems among pregnant women. This study evaluated the effectiveness of an in-service nutrition education and counselling package on the providers’ counselling skills during ANC visits. A cluster randomized controlled trial was conducted in Addis Ababa, Ethiopia. All health-care providers working in ANC units across 20 health centres participated in this study. Health centres were allocated to intervention and control arms using a matched-pair randomization technique. An in-service nutrition education and counselling package, including training for ANC providers, supportive supervision and provision of modules, pamphlets and job aids, was provided for health centres assigned to the intervention arm. Observation checklists were used to assess the counselling skills of health-care providers. We used mixed-effect linear regression to evaluate the impact of the intervention. Significantly more health-care providers in the intervention arm informed pregnant women about the need to have one additional meal (Difference in proportion [DP] 49.17% vs −0.84%; DID 50.0%), about minimum required dietary diversity (DP 72.5% vs −2.5%; DID 75.0%) and about gestational weight gain (DP 68.33% vs −8.33%; DID 76.6%). Furthermore, providers improved in identifying key difficulties that pregnant women face (DP 28.34% vs −2.5%; DID 30.8%), and in recommending simple achievable actions on nutrition during pregnancy (DP 20.8% vs −10.9%; DID 31.6%). The intervention did not have statistically significant effects on how providers informed women about early initiation of breastfeeding (DP 6.67% vs 9.17%; DID −2.5%). The comprehensive in-service nutrition education and counselling package improved how ANC providers engaged with pregnant women and delivered nutrition messages during ANC consultations. This trial was registered in the Pan African Clinical Trial (PACTR registry, PACTR20170900 2477373; Date issued 21 September 2017).
Mild stimulation should be mandatory for oocyte donation
Authors: Pennings Guido 
Published: August 2020

ABSTRACT
The increasing commercialization of oocyte donation is a source of concern. This evolution is expressed in the fact that oocyte donors’ interests are not a priority. For decades now, people mention that oocyte donation holds serious health risks for donors, as if this is an unavoidable given. However, most of the harm is caused by high hormonal stimulation. The risk/benefit balance of high stimulation compared to the risk/benefit balance of mild stimulation does not justify causing greater harm to donors, especially given the fact that donors submit to the procedure without any medical benefit for themselves and to help others.
Prediction of square mesh panel and codend size selectivity of blue whiting based on fish morphology
Authors: Cuende Elsa , Arregi Luis , Herrmann Bent , Sistiaga Manu , Aboitiz Xabier 
Published: August 2020

Abstract
Square mesh panels (SMPs) are selective devices used extensively to supplement codend size selectivity in trawl fisheries. Therefore, predictions of the effect of mesh size in both SMPs and codends on size selectivity are valuable. Here, we established a framework to predict the size selection of blue whiting through different SMPs and diamond mesh codends based on the morphological characteristics of this species. We hypothesized that size selection for an SMP is determined by different fish contact angles, whereas different mesh opening angles determine size selection for the codend. Based on these hypotheses, we first developed a model that enabled us to predict which sizes of blue whiting are able to pass through meshes of different sizes and shapes. We then tested whether the selectivity for blue whiting of the SMP, the codend, and the combination of both could be explained by the models. Finally, we predicted the size selectivity of multiple combinations of SMPs and diamond mesh codends. The method presented here can potentially be applied to make predictions for species other than blue whiting.
Preempting the Entry of Near Perfect Substitutes
Authors: Lipatov Vilen , Neven Damien , Siotis Georges 
Published: August 2020

Abstract
When firms compete on price and quality-enhancing promotion in a market for differentiated products, entry of a nearly perfect substitute to one of such products, for example, a generic version of a pharmaceutical drug, intensifies price competition but softens quality competition. We show that consumers are likely to gain from entry when quality is relatively unimportant for them, when business stealing generated by promotion is substantial, and when products are poor substitutes. We also show that entry may be more attractive for consumers in less concentrated markets, as a smaller number of firms and asymmetric market shares may be associated with higher quality.
Anastomosis of dual renal transplant veins
Authors: Hoff Mekhola , Leighton Philippa , Hosgood Sarah A , Nicholson Michael L 
Published: August 2020

Abstract
As there is usually considerable overlap in the renal venous drainage, it is often possible to ligate supernumerary transplant renal veins in order to simplify the implantation procedure. Nonetheless, decisions about whether to implant multiple veins can be difficult and are usually made subjectively. Here, we describe the use of intraoperative Doppler ultrasound as an adjunct to decision-making when there are two renal veins and a novel technique for the sequential anastomosis of dual veins. The kidney was reperfused after anastomosis of the main renal vein with the second vein clamped. On-table Doppler ultrasound demonstrated reversed flow in diastole indicating that the second renal vein also needed to be anastomosed. By clamping the external iliac vein inferior to the first venous anastomosis it was possible to complete the lower polar renal vein anastomosis to the external iliac vein without interrupting the perfusion of the kidney.
The KBC void and Hubble tension contradict ΛCDM on a Gpc scale − Milgromian dynamics as a possible solution
Authors: Haslbauer Moritz , Banik Indranil , Kroupa Pavel 
Published: August 2020

ABSTRACT
The KBC void is a local underdensity with the observed relative density contrast δ ≡ 1 − ρ/ρ0 = 0.46 ± 0.06 between 40 and 300 Mpc around the Local Group. If mass is conserved in the Universe, such a void could explain the 5.3σ Hubble tension. However, the MXXL simulation shows that the KBC void causes 6.04σ tension with standard cosmology (ΛCDM). Combined with the Hubble tension, ΛCDM is ruled out at 7.09σ confidence. Consequently, the density and velocity distribution on Gpc scales suggest a long-range modification to gravity. In this context, we consider a cosmological MOND model supplemented with $11 \, \rm {eV}/c^{2}$ sterile neutrinos. We explain why this νHDM model has a nearly standard expansion history, primordial abundances of light elements, and cosmic microwave background (CMB) anisotropies. In MOND, structure growth is self-regulated by external fields from surrounding structures. We constrain our model parameters with the KBC void density profile, the local Hubble and deceleration parameters derived jointly from supernovae at redshifts 0.023−0.15, time delays in strong lensing systems, and the Local Group velocity relative to the CMB. Our best-fitting model simultaneously explains these observables at the $1.14{{\ \rm per\ cent}}$ confidence level (2.53σ tension) if the void is embedded in a time-independent external field of ${0.055 \, a_{_0}}$. Thus, we show for the first time that the KBC void can naturally resolve the Hubble tension in Milgromian dynamics. Given the many successful a priori MOND predictions on galaxy scales that are difficult to reconcile with ΛCDM, Milgromian dynamics supplemented by $11 \, \rm {eV}/c^{2}$ sterile neutrinos may provide a more holistic explanation for astronomical observations across all scales.
Inevitable consequences of ion–neutral damping of intermediate MHD waves in Sun-like stars
Authors: Judge Philip G 
Published: August 2020

ABSTRACTIn the context of the solar atmosphere, we re-examine the role of neutral and ionized species in dissipating the ordered energy of intermediate-mode MHD waves into heat. We solve conservation equations for the hydrodynamics and for hydrogen and helium ionization stages, along closed tubes of magnetic field. First, we examine the evolution of coronal plasma under conditions where coronal heating has abruptly ceased. We find that cool (&lt;105K) structures are formed lasting for several hours. MHD waves of modest amplitude can heat the plasma through ion–neutral collisions with sufficient energy rates to support the plasma against gravity. Then we examine a calculation starting from a cooler atmosphere. The calculation shows that warm (&gt;104) K long (&gt; several Mm) tubes of plasma arise by the same mechanism. We speculate on the relevance of these solutions to observe properties of the Sun and similar stars whose atmospheres are permeated with emerging magnetic fields and stirred by convection. Perhaps this elementary process might help to explain the presence of ‘cool loops’ in the solar transition region and the production of broad components of transition region lines. The production of ionized hydrogen from such a simple and perhaps inevitable mechanism may be an important step towards finding the more complex mechanisms needed to generate coronae with temperatures in excess of 106K, independent of a star’s metallicity.
The effects of resolution on black hole accretion simulations of jets
Authors: White Christopher J , Chrystal Fiona 
Published: August 2020

ABSTRACT
We perform three general-relativistic magnetohydrodynamic simulations of black hole accretion designed to test how sensitive results are to grid resolution in the jet region. The cases differ only in numerics, modelling the same physical scenario of a radiatively inefficient, geometrically thick, magnetically arrested flow on to a rapidly spinning black hole. Properties inferred with the coarsest grid generally agree with those found with higher resolutions, including total jet power and its decomposition into different forms, velocity structure, non-axisymmetric structure, and the appearance of resolved millimetre images. Some measures of variability and magnetization are sensitive to resolution. We conclude that most results obtained by limiting resolution near the jet for computational expediency should still be reliable, at least in so far as they would not be improved with a finer grid.