bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expectations and Experiences with Physician Care Among Patients Receiving Post-Acute Care in US Skilled Nursing Facilities
Authors: Ryskina Kira L , Foley Kierra A. , Karlawish Jason H. , Uy Joshua D. , Lott Briana , Goldberg Erica , Hodgson Nancy A. 
Published: July 2020

Abstract
Background and Objectives: In the US, post-acute care in skilled nursing facilities (SNFs) is common and outcomes vary greatly across facilities. Little is known about the expectations of patients and their caregivers about physician care during the hospital to SNF transition. Our objectives were to (1) describe the experiences and expectations of patients and their caregivers with SNF physicians (or advanced practitioners such as nurse practitioners) in SNFs, and (2) identify patterns that differed between patients with vs. without cognitive impairment.Research Design and Methods: This qualitative study used grounded theory approach to analyze data collected from semi-structured interviews at five SNFs in January-August 2018. Patients admitted for short-term SNF care 5-10 days prior were eligible to participate. Thematic analysis was performed to detect recurrent themes with a focus on modifiable aspects of physician care. Analysis was stratified by patient cognitive impairment (measured by the Montreal Cognitive Assessment at the time of the interview). Results: Fifty patients and six caregivers were interviewed. Major themes were: (1) patients had poor awareness of the physician in charge of their care; (2) they were dissatisfied with the frequency of interaction with the physician; and (3) participants valued the perception of receiving individualized care from the physician. Less cognitively impaired patients were more concerned about limited interactions with the clinicians and were more likely to report attempts to seek out the physician. Discussion and Implications: Patient and caregiver expectations of SNF physicians were not well aligned with their experiences. SNFs aiming to improve satisfaction with care may focus efforts in this area, such as facilitating frequent communication between physicians, patients and caregivers.
Differential effects of serum lipoprotein-associated phospholipase A2 on periventricular and deep subcortical white matter hyperintensity in brain
Authors: Jiang Junying , Gao Yuanyuan , Zhang Rui , Wang Lin , Zhao Xiaoyuan , Dai Qi , Zhang Wei , Xu Xiujian , Chen Xuemei 
Published: July 2020

Abstract
Background: High lipoprotein-associated phospholipase A2 (Lp-PLA2) was associated with white matter hyperintensity (WMH). There were differences in the anatomical structure and pathophysiological mechanism between periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH). In this study, we aimed to investigate the effects of serum Lp-PLA2 on the PVWMH and DSWMH. Methods: This cross-sectional study recruited 711 Chinese adults aged ≥45 years presented to the Department of Neurology, the Affiliated Jiangning Hospital of Nanjing Medical University between January 2016 and July 2019. Enzyme linked immunosorbent assay (ELISA) was utilized to determine the serum Lp-PLA2. Fazekas scale was used to measure the severity of PVWMH and DSWMH. Ordinal logistic regression analysis was carried out to investigate the relationship between serum Lp-PLA2 and PVWMH or DSWMH. Results: A total of 567 cases were included in this study. Ordinal logistic regression analysis indicated that, after adjusting for the confounding variables, there was a lower risk of PVWMH in the patients with normal and moderately elevated serum Lp-PLA2 compared with those with significantly elevated serum Lp-PLA2. In addition, PVWMH was correlated to advanced age, hypertension, diabetes mellitus, and lacunar infarction. DSWMH was correlated to advanced age and lacunar infarction. There was no correlation between serum Lp-PLA2 and DSWMH. Conclusions: Serum Lp-PLA2 was closely associated with the pathogenesis of PVWMH rather than DSWMH. There might be different pathological mechanisms between PVWMH and DSWMH.
Multiple gene targeting siRNAs for down regulation of Immediate Early-2 (Ie2) and DNA polymerase genes mediated inhibition of novel rat Cytomegalovirus (strain All-03)
Authors: Balakrishnan Krishnan Nair , Abdullah Ashwaq Ahmed , Bala Jamilu Abubakar , Jesse Faez Firdaus Abdullah , Abdullah Che Azurahanim Che , Noordin Mustapha Mohamed , Azmi Mohd Lila Mohd 
Published: July 2020

Abstract
Background
Cytomegalovirus (CMV) is an opportunistic pathogen that causes severe complications in congenitally infected newborns and non-immunocompetent individuals. Developing an effective vaccine is a major public health priority and current drugs are fronting resistance and side effects on recipients. In the present study, with the aim of exploring new strategies to counteract CMV replication, several anti-CMV siRNAs targeting IE2 and DNA polymerase gene regions were characterized and used as in combinations for antiviral therapy.
Methods
The rat embryo fibroblast (REF) cells were transfected with multi siRNA before infecting with CMV strain ALL-03. Viral growth inhibition was measured by TCID50, cytopathic effect (CPE) and droplet digital PCR (ddPCR) while IE2 and DNA polymerase gene knockdown was determined by real-time PCR. Ganciclovir was deployed as a control to benchmark the efficacy of antiviral activities of respective individual siRNAs.
Results
There was no cytotoxicity encountered for all the combinations of siRNAs on REF cells analyzed by MTT colorimetric assay (P > 0.05). Cytopathic effects (CPE) in cells infected by RCMV ALL-03 developed significantly less and at much slower rate compared to control group. The expression of targeted genes was downregulated successfully resulted in significant reduction (P < 0.05) of viral mRNA and DNA copies (dpb + dpc: 79%, 68%; dpb + ie2b: 68%, 60%; dpb + dpc + ie2b: 48%, 42%). Flow cytometry analysis showed a greater percentage of viable and early apoptosis of combined siRNAs-treated cells compared to control group. Notably, the siRNAs targeting gene regions were sequenced and no any mutation was identified, thereby avoiding the formation of mutant with potential resistant viruses.
Conclusions
In conclusion. The study demonstrated a tremendous promise of innovative approach with the deployment of combined siRNAs targeting at several genes simultaneously with the aim to control CMV replication in host cells.
Test–Retest Reproducibility Analysis of Bone Mineral Densitometry Radiomics Features
Authors: Qasempour Younes , Akhash Mohammad Rashid , Shiri Isaac , Hajianfar Ghasem , Abdalvand Neda , Abdollahi H 
Published: July 2020

Abstract
Background

Radiomics features reproducibility assessment is a critical issue in imaging biomarker development era. In the present study, we aimed to assess test–retest reproducibility analysis of bone mineral densitometry (BMD) image radiomics features.
Methods

In this prospective research work, eighteen patients were included and were subjected to DXA BMD scans acquired within 10 min of each other under an approved protocol. Seven regions of interest (ROIs) including four lumbar spine regions (L1-L4) and three hip regions (trochanteric, inter trochanteric and neck) in both test and re-test images were segmented and 107 radiomics features from seven different feature sets were extracted. Intra-class correlation coefficient (ICC) were initially used to estimate radiomics features reproducibility.
Results

We showed that there is no radiomics feature with 90% < ICC < 100% in all ROIs, but there are three feature including Strength (from NGTDM feature set), SALGLE (Small Area Low Gray Level Emphasis) (from GLSZM feature set) and Busyness (from NGTDM feature set) with ICC < 70% in all eight ROIs. Shape features has features with ICC < 70%.
Conclusion

Our study on test–retest reproducibility analysis of bone mineral densitometry radiomics features shows radiomics features have several variations against changes of time of image acquisition. The reproducible features may be used as imaging biomarkers in the field of clinical densitometry. The results of this study may be repeated by more radiomics features and more BMD scanners as first line for bone mineral biomarker discovery.
The association of parent-child communication with Internet addiction in left-behind children in China
Authors: Cai Jingjing , Wang Yun , Wang Feng , Lu Jingjing , ZHOU Xudong , Li Lu 
Published: July 2020

Abstract
Background

Long-term absence of parents has been proven to lead to negative health outcomes on left-behind children (LBC). We saw numerous studies that explored the association of parental absence with mental health and risky behaviors among LBC. Recently, Internet addiction has emerged as a growing concern, however, it was seldom studied among LBC community. This study aimed to compare the prevalence of Internet addiction between LBC and non-left-behind children (non-LBC), and explore the role of paternal and maternal parent-child communication on LBC.
Methods

We conducted a questionnaire survey in rural areas in Anhui, China, including the Parent-Adolescent Communication Scale and Young’s Internet addiction Test. LBC who reported both migrating parents and children who lived with both non-migrating parents were included in this study.
Results

The complete data were available from 699 LBC and 740 non-LBC. After adjustment of social-demographic characteristics, the result indicated LBC had a higher likelihood to report internet-addiction when compared to non-LBC (OR = 2.03, 95%CI = 1.43–2.88, p < 0.001). Among LBC, parent-child communication (both mother-child and father-child) was protective factors for children’s Internet addiction. Also, the role of mother-child communication played well in preventing boys from Internet addiction.
Conclusions

Our findings suggested the lack of parental supervision may lead to Internet addiction. It is highly recommended for migrant parents to improve the quality of communication with their children. Also, gender-matching effects should be considered in the relationship between children’s behavior and parental factors.
Drug-induced liver injury due to the infliximab biosimilar CT-P13 on switching from original infliximab in a patient with Crohn’s disease
Authors: Fujiya Mikihiro , Kashima Shin , Kobayashi Yu , Sugiyama Yuya , Murakami Yuki , Sato Hiroki , Sasaki Takahiro , Kunogi Takehito , Hayashi Hidemi , Takahashi Keitaro , Hasebe Takumu , Nakajima Shunsuke , Ando Katsuyoshi , Ueno Nobuhiro , Goto Takuma , Sawada Koji , Moriichi Kentaro , Tanabe Hiroki , Mizukami Yusuke , Okumura Toshikatsu 
Published: July 2020

Abstract
Background

IBD are chronic immune disorders of unclear etiology. TNF inhibitors are effective for IBD treatment but are much more expensive than traditional treatments. A large number of clinical trials of infliximab biosimilar (CT-P13) have suggested that the administration of biosimilars provides high efficacy and safety similar to that of the originators, with a lower cost, so switching from the originator to the biosimilar is recommended. While several abnormalities of blood examination have been observed in patients with CT-P13 administration, no cases of drug-induced liver injury (DILI) caused by CT-P13 has been reported.
Case presentations:

A 32-year-old woman had been diagnosed with Crohn’s disease and was treated with original infliximab (O-IFX) for 9 years. She developed severe jaundice one month after switching from O-IFX to CT-P13. Serologic tests of auto-immune and hepatitis viruses were negative, and ultrasonography, computed tomography and magnetic resonance cholangiopancreatography revealed no abnormalities. A liver biopsy showed prominent pericentral canalicular cholestasis, without features of steatosis or sclerosing cholangitis, which was consistent with drug-induced cholestasis. The cholestasis improved 10 weeks after the discontinuation of CT-P13, and no DILI redeveloped even after re-switching from CT-P13 to O-IFX. This is the first report of DILI due to switching from O-IFX to CT-P13.
Conclusions

This is the first report of DILI due to switching from O-IFX to CT-P13, and our case suggests the different immunogenicity between O-IFX and CT-P13. While the efficacy and safety of CT-P13 are considered equal to those of O-IFX, clinicians need to be alert for certain severe DILIs when switching from O-IFX to CT-P13 with careful monitoring and appropriate treatment.
Differential diagnosis of parkinsonian degenerative disorders in combination manual measurements with automated volumetry of the brain
Authors: Zhang Yiwei , Wang Han , Xu Dan , Hou Bo , Lin Tianye , Shi Lin , Luo Yishan , You Hui , Feng Feng 
Published: July 2020

Abstract
Background: To compare brain morphological differences in progressive supranuclear palsy (PSP), multiple system atrophy with the parkinsonian variant (MSA-P), Parkinson’s disease (PD) and controls by manual and automated measurements and to explore the feasibility of these measurements in disease differentiation.Methods: Ninety-five PSP patients (48 males, mean age 67.9 y), 32 MSA-P patients (18 males, mean age 63.0 y), 136 PD patients (72 males, mean age 66.6 y) and 100 controls (50 males, mean age 66 y) were included. The 12 manual measurements were acquired. Relative brain structural volumes adjusted according to the intracranial volume (ICV) of different brain regions werealsoquantified. Differences among and between groups were evaluated. Receiver operating characteristic curve analysis was used to assess diagnostic performance and define cutoff values of these measures.Results: P/M area 2.0displayed the highest diagnostic performance (AUC: 0.801) for distinguishing PSP from MSA-P or PD (sensitivity69.5%, specificity 82.1%). Furthermore, the combination of morphological features in manual parameters (P/M area 2.0, MRPI and M/P diameter) and volume atrophy in the midbrain improved the PSP discrimination (AUC: 0.870, sensitivity 76.8%, specificity 83.9%). The relative volume of the putamen can better differentiate MSA-P from PSP and PD (AUC: 0.844, sensitivity 81.3%, specificity 75.3%). Similarly, the ability to differentially diagnose MSA-P increased most significantly (AUC: 0.927, sensitivity 87.5%, specificity 87.9%) when combing volume atrophy in the putamen with the caudate and manual parameter (M/P diameter).Conclusion: Manual and automated MR variables can reveal atrophy features of the brain and be helpful in the differential diagnosis.
Rehabilitation of Individuals With Schizophrenia: a Scoping Review Protocol of Evidence From Sub-saharan Africa
Authors: Oyelade Oyeyemi Olajumoke , Nkosi-Mafutha Nokuthula Gloria 
Published: July 2020

Abstract
Background: The rehabilitation of an individual with mental illness is an evidenced-based approach to reducing the burden of the illness and the associated stigma globally. Specifically, in Africa, it has promising value for African life and the African economy. Psychosocial rehabilitation is described as a set of approaches that aim to assist an individual in achieving restoration from a state of dependency caused by schizophrenia to a state of being an independent decision-maker. However, there seems to be a dearth of literature and implementation of psychosocial rehabilitation in Africa. Therefore, it is necessary to map articles on how rehabilitation is conducted for people living with the most chronic form of mental illness, schizophrenia, in Africa.Methods: This study will adopt the Arsey and O’Malley scoping review framework to search and compile relevant articles. This process will involve three steps: title screening, which will be performed solely by the principal investigator, followed by abstract and full-text screening, which will be performed independently by two reviewers (the principal investigator and co-investigator). The data charting form will be used by both reviewers for screening, while Rayyan QCRI, a systematic reviews web app, will be used for tracking the screening records. The quality of articles identified for screening will be assessed by the Mixed Method Appraisal Tool (MMAT), and content analysis of the screened articles will be performed with NVivo.Discussion: This study has the likelihood of revealing a research gap in rehabilitation approaches and methods. The results of the review will constitute part of the available evidence that the researchers aim to adopt in the broader part of the project, which aims to develop implementation strategies for the rehabilitation of chronic mental illnesses, specifically schizophrenia, in Sub-Saharan Africa. The implementation process also encompasses the dissemination of the findings of this review to stakeholders, which will enhance their knowledge of the current state of Sub-Saharan Africa and may stimulate support for the implementation of rehabilitation strategies.
Analysis of Stress, Strain, and Fatigue Strength of the Rotary Table of Boom-Type Roadheaders
Authors: tian Jie , Zhang Lansheng , YAO Haifeng , WU Miao 
Published: July 2020

Abstract
The rotary table is the key component in the optimal design of roadheaders. In this study, a simulation model of the cutting part and a rotary table is established in SolidWorks, and stress analysis and strength evaluation of the structure of the rotary table are performed. To this end, finite element analysis is performed on the basis of the dynamic theory of a coupled multibody system comprising rigid and flexible bodies. Considering actual working conditions, the load file of the cutting head is calculated based on the development of the “Roadheader Machine load Calculation Program”, and the stress and strain cloud map of the cutting head running to the bottom left, middle end, and right end of the rotary table is obtained through Adams simulation. Then, the 6-order modal analysis is carried out, and the S-N curve of the turntable is finally established. In addition, the fatigue life reliability of the turntable is analyzed using the AWE fatigue module. The results show that, provided reliable working conditions, the EBZ160 type roadheader machine during the normal service life shows no risk of fatigue failure under normal working load.
Enchondroma of the spine: a report of eleven cases
Authors: Liu Dehuai , Li Boxiang , Wang Hui , Luo Kai , Lin Chengsen , Chen Xianxiang , Liu Yun , Tang Haijun 
Published: July 2020

Abstract
Purpose

To explore clinical characteristics, surgical strategies, and prognosis of spinal enchondroma.
Methods

We retrospectively analyzed eleven cases with primary benign spinal enchondroma who were treated in our institution between January 2008 and December 2016.
Results

Of the 11 patients included in our study, the average age was 43 years(range from 5–66 years). There were 7 men and 4 women. The lesions were mainly located in the lumbar and thoracic column with 5 cases and 4 cases respectively, and following by the cervical and sacral vertebrae with both 1 cases. Total tumor resection was used in 10 cases and curettage in one case. The average follow-up was 3.3 years(range from 2 to 6 years). Most of the cases had achieved satisfied therapeutic outcome with the symptoms disappeared. However, Case 9 developed into local recurrence and a second surgery was performed. Although the lesion have not recured any more after the second operation during the follow-up, the lower extremity paralysis had no improvement. Case 2 was sent to our hospital for the recurrence of the sacral tumor which was very closed to the common iliac artery.When the second operation was conducted, the artery was ruptured and the patient died from hemorrhagic shock.
Conclusion

To establish the diagnosis of spinal enchondroma is not always a simple job for the absence of specific clinical characteristics. The optimal treatment is total resection. Although spinal enchondroma is benign, a few cases can develop into local recurrence. Sacral enchondroma should be more vigilant for its fatal complications.
Anticancer effects of miR-124 delivered by BM-MSC derived exosomes on cell proliferation, epithelial mesenchymal transition, and chemotherapy sensitivity of pancreatic cancer cells
Authors: Xu Yan , Liu Nanbin , Wei Yuhua , Zhou Deren , Lin Rui , Wang Xiuyan , Shi Baomin 
Published: July 2020

Abstract
Objective
This study aims to explore the roles of miR-124 in pancreatic tumor and potential vehicles.
Methods
The expression of miR-124 and EZH2 was determined in both pancreatic cancer tissues and cell lines. miR-124 or EZH2 was overexpressed in AsPC-1 and PANC1 cells. Then, the effects on cell viability. apoptosis, invasion, migration and epithelial mesenchymal transition were evaluated. Afterwards, the roles of miR-124 on the expression and function of EZH2 in pancreatic tumors were determined by dual luciferase reporter assay. Subsequently, miR-124 was transfected to bone marrow mesenchymal stromal cells (BM-MSCs), and the BM-MSCs derived exosomes were isolated and co-cultured with AsPC-1 and PANC1 cells, or injected into pancreatic cancer tumor-bearing mice.
Results
The miR-124 expression levels decreased in pancreatic adenocarcinoma tissues and cancer cell lines AsPC-1, PANC1, BxPC-3 and SW1990. Furthermore, the elevated expression of miR-124 in AsPC-1 and PANC1 via miR-124 mimic transfection-induced apoptosis, metastasis and epithelial mesenchymal transition was suppressed, and the EZH2 overexpression partly reversed the protective effects of miR-124 against pancreatic tumors. In addition, the expression of miR-124 was detected in exosomes extracted from miR-124-transfected BM-MSCs, and these exosomes delivered miR-124 into pancreatic cancer cells, and presented the anti-tumor effects in vitro and in vivo.
Conclusion
MiR-124-carried BM-MSC-derived exosomes have potential applications for the treatment of pancreatic tumors.