bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of pharmacy-supported interventions on proportion of patients receiving non-indicated acid suppressive therapy upon discharge: A systematic review and meta-analysis
Authors: Singh-Franco Devada , Mastropietro David R. , Metzner Miriam , Dressler Michael D. , Fares Amneh , Johnson Melinda , De La Rosa Daisy , Wolowich William R. 
Published: December 2020

ObjectiveConduct a systematic review and meta-analysis to estimate the impact of pharmacy-supported interventions on the proportion of patients discharged from the hospital on inappropriate acid suppressive therapy (AST).MethodsTo identify studies, the following databases were systematically searched on October 14th, 2018 and repeated on September 12th, 2019: Ovid MEDLINE(R) and In-Process & Other Non-Indexed Citations and Daily,Embase.com, CINAHL, Web of Science, Cochrane CENTRAL (EBSCO), and ClinicalTrials.gov. Eligible studies consisted of adults, intervention and historical/usual care groups, description of active pharmacy-supported intervention, and proportion of patients discharged on inappropriate AST. Qualitative assessments and quantitative analyses were performed. Modified funnel plot analysis assessed heterogeneity. Preferred reporting items of systematic reviews and meta-analyses (PRISMA) methodology was used to evaluate studies in this review.ResultsSeventeen publications resulting in 16 studies were included in the review. Using random effects model, meta-analysis showed a significant reduction in the odds of being discharged on inappropriate AST from the hospital in the pharmacist-supported intervention arm versus comparator (Odds Ratio 0.33 [95%CI 0.20 to 0.53]), with significant heterogeneity (I2= 86%). Eleven studies favored pharmacy-supported interventions, four were inconclusive and one favored usual care. Using modified funnel plot analysis, our final evaluation was distilled to 11 studies and revealed a similar outcome (OR 0.36 [95%CI 0.27 to 0.48]), but with less heterogeneity (I2= 36%).ConclusionThis systematic review and meta-analysis showed that pharmacy-supported interventions were associated with a significantly reduced probability of patients discharged on inappropriate AST. However, heterogeneity was high and may affect interpretation of results. Using funnel plot optimization method, three positive and two negative studies were objectively removed from analyses, resulting in a similar effect size, but with less heterogeneity. To improve study quality, future researchers should consider utilizing a pre-post, multi-arm, prospective design with sampling randomization, training of data extractors (preferably two extractors), re-evaluating a small dataset to check for agreement and providing a comprehensive methodology in subsequent publications.
N-Terminal pro-B-type natriuretic peptide and coronary microvascular dysfunction in women with preserved ejection fraction: A report from the Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction (WISE-CVD) study
Authors: Jones Erika , Wei Janet , Nelson Michael D. , Bakir May , Mehta Puja K. , Shufelt Chrisandra , Minissian Margo , Sharif Behzad , Pepine Carl J. , Handberg Eileen , Cook-Wiens Galen , Sopko George , Bairey Merz C. Noel 
Published: December 2020

Background
Women with symptoms and signs of ischemia, preserved left ventricular ejection fraction (LVEF), and no obstructive coronary artery disease (CAD), often have coronary microvascular dysfunction (CMD), and are at risk of future heart failure with preserved ejection fraction (HFpEF). N-terminal pro-B-type natriuretic peptide (NT-proBNP) is used to evaluate HF and myocardial ischemia. Relationships between NT-proBNP and CMD are not well defined in this population.

Methods
We evaluated resting NT-proBNP levels in 208 women with symptoms and signs of ischemic heart disease, preserved LVEF and no obstructive CAD undergoing clinically indicated invasive coronary flow reserve (CFR) as a measure of CMD-related ischemia and resting left ventricular end-diastolic pressure (LVEDP). Chi-square testing was used for categorical variables and ANOVA or Kruskal-Wallis tests were used for continuous variables.

Results
Overall, 79% had an elevated resting LVEDP, and mean NT-proBNP was 115 ± 158 pg/mL. NT-proBNP levels correlated directly with age (r = 0.28, p = <0.0001), and indirectly with body mass index (r = -0.21, p = 0.0006), but did not independently associate with CFR. When stratified by NT-proBNP thresholds, higher NT-proBNP was initially associated with lower CFR, which did not persist with adjustment for multiple testing (p = 0.01 and 0.36, respectively).

Conclusion
Among women with symptoms and signs of ischemia, preserved LVEF, no obstructive CAD, and undergoing clinically indicated functional coronary angiography (FCA) for suspected CMD, while a majority had elevated resting LVEDP, we failed to find an independent association between CFR and NT-proBNP, although stratified clinical thresholds may relate to lower CFR. Further work is needed to investigate if these findings support the hypothesis that CMD-related ischemia may be a precursor to HFpEF.
Acute leucocyte, muscle damage, and stress marker responses to high-intensity functional training
Authors: Gomes João Henrique , Mendes Renata Rebello , Franca Crystianne Santana , Da Silva-Grigoletto Marzo Edir , Pereira da Silva Danilo Rodrigues , Antoniolli Angelo Roberto , de Oliveira e Silva Ana Mara , Quintans-Júnior Lucindo José 
Published: December 2020

Background
High-intensity functional training (HIFT) has become more popular, and the number of practitioners has increased; however, it remains unclear whether perturbations in the immune parameters occur, even after one single bout. Our aim was to examine acute leucocyte, muscle damage, and stress marker responses following a single ‘Cindy’ workout session, and compare the results between novice and experienced participants.

Material and methods
Twenty-three HIFT practitioners (age 31.0 ± 1.0 years) completed the ‘Cindy’ workout. They were categorized as novice (3–8 months of experience; n = 10) and experienced (≥18 months; n = 13). White blood cell (WBC) count, plasma creatine kinase (CK) activity, blood cortisol level, and lactate concentration were measured. Blood analysis was performed before (pre-ex), immediately after (post-ex), 30 min after (post-30 min), and 24 h after (post-24 h) a single ‘Cindy’ workout session.

Results
WBC count was higher post-ex (6.8 to 11.8x103/μL) and returned to baseline values within post-30 min (p<0.01). Neutrophil (3.3 to 4.5x103/μL) and lymphocyte levels (2.8 to 5.9x103/μL) were higher post-ex and returned to baseline values after post-24 h, yet lymphocytopoenia (2.2x103/μL) was observed at post-30 min (p<0.01). CK increased post-ex (174.9 to 226.7 U.L-1) and remained elevated post-24 h. Cortisol (14.7 to 17.0 μg/dL) and lactate (1.9 to 13.5 mmol.l-1) responses increased post-ex, but only the lactate level was reduced at post-30 min (p<0.01). The experienced participants had higher WBC, lymphocyte, and cortisol concentrations post-ex than the novice ones (p<0.01).

Conclusions
A single HIFT session elicited significant acute perturbations in WBC count, stress markers, and muscle tissue, which is like other similar regimens. Importantly, the experienced participants showed greater lymphocyte and cortisol responses than the novice ones.
Utilization of institutional delivery and associated factors among mothers in Hosanna Town, Hadiya Zone, Southern Ethiopia: A community-based cross-sectional study
Authors: Anshebo Demeke , Geda Bifitu , Mecha Aregash , Liru Alemu , Ahmed Ritbano 
Published: December 2020

Background
Institutional delivery is one of the key interventions that have been proven to reduce maternal and newborn morbidity and mortality. Ethiopia has initiated different efforts to enhance the acceptance of institutional delivery. In spite of this, the number of institutional deliverys is still very low in Ethiopia and varies from region to region. Therefore, this study aimed to assess the utilization of institutional delivery and of factors associated with it among mothers in Hossana Town, Southern Ethiopia.

Methods
This study was a community-based cross-sectional study of mothers who had given birth within 12 months before the study. Data were collected using a pretested questionnaire. During the study period, 403 mothers were selected using the systematic random sampling technique. Data entry was done using EpiData (version 3.1), and data were exported to SPSS (version 24) for analysis. Both bivariate and multivariable logistic regression analyses were used to identify the associated factors at 95% CI.

Results
This study revealed that 53.6% of mothers delivered their infants at health facilities. The factors associated with the institutional delivery were primigravidas (AOR = 3.9; 95% CI, 1.4–4.7), the availability of antenatal care (AOR = 3.4; 95%CI, 1.7–7.2), having planned pregnancies (AOR = 3.9; 95%CI, 1.7–9.3) and the involvement of both parents in decision making (AOR = 2.4; 95%CI, 1.4–2.5). However, when only the mother was involved in the decision making regarding the delivery, the figure decreased by 70% (AOR = 0.3; 95%CI, 0.1–0.8).

Conclusions
The findings of this study indicate that high numbers of births occur without skilled attendants or are non- institutional delivery. In terms of the factors that are associated with institutional delivery, the study suggests that strengthening sustained provision of education during antenatal care and at community levels are crucial.
The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure
Authors: Parahita Astra , Hardaningsih Galuh , Soetadji Anindita 
Published: December 2020

Background: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. Objective: The study aims is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sectional study was conducted to 50 children aged between 8 – 10 years in agriculture areas of Brebes. Serum MDA and NO level was measured at the same time using ELISA method, data were shown on numerical scale. Statistical analysisby Pearson correlation.Result: Fifty children met the criteria, consisting of 30 males (60%) and 20 females (40%). The mean of serum MDA level in males, females, and total subjects were normal 6.03 (3.86) µg/ mL, 5.18 (2.11) µg/ mL, and 5.69 (2.60) µg/ mL, respectively. The mean of serum NO level in males, females, and total subjects were increased 79.42 (50.78) µmol/ L, 68.11 (50.81) µmol/ L, and 74.90 (50.58) µmol/ L, respectively. There was no association between serum MDA and NO level found.Conclusion: Serum NO level of children living in an area of chronic pesticide exposure was higher than normal value. However, there was no association between serum MDA and NO level found.
Phototherapy Improves Muscle Recovery and Does Not Impair Repeated Bout Effect in Plyometric Exercise
Authors: Padoin Susana , Zeffa Aline C. , Molina Corrêa Julio C. , de Angelis Tarlyson R. , Moreira Thuany B. , Barazetti Lilian K. , de Paula Ramos Solange 
Published: December 2020

Abstract
Padoin, S, Zeffa, AC, Molina Corrêa, JC, de Angelis, TR, Moreira, TB, Barazetti, LK, and de Paula Ramos, S. Phototherapy improves muscle recovery and does not impair repeated bout effect in plyometric exercise. J Strength Cond Res 36(12): 3301–3310, 2022—The effects of photobiomodulation with red (630 nm) and near-infrared (940 nm) light wavelengths were investigated on the inhibition of exercise-induced muscle damage (EIMD) and adaptation to the repeated bout effect (RBE). Twenty-eight healthy men were randomized to receive light-emitting diode therapy (LEDT) at 630 nm (4.6 J·cm−2, 97 J energy), LEDT at 940 nm (4.6 J·cm−2, 114 J), or placebo. After LEDT or placebo treatment, subjects performed 100 drop-jumps (5 sets of 20 repetitions). Creatine kinase, delayed-onset muscle soreness (DOMS), countermovement jump (CMJ), and squat jump (SJ) were assessed before, immediately after, and 24, 48, and 72 hours after the bout. After 14 days, the subjects were submitted to the same plyometric exercise, without LEDT, and were evaluated again. Creatine kinase levels increased significantly 72 hours after the first bout in the placebo group in relation to the LEDT 940-nm group (P < 0.01). The LEDT 630-nm group showed a significant increase in SJ at 24 hours (P < 0.05), whereas, at 48 hours, the LEDT 940 nm showed a significant increase compared with the placebo group (P < 0.05). The 2-way analysis of variance revealed an effect for treatment in the SJ (F = 7.12; P = 0.001). No differences were found between groups for DOMS and CMJ after the first bout. After the second bout of exercise, there was no effect of treatment. The results suggest that treatment with LEDT 630 nm and LEDT 940 nm before eccentric exercise attenuates EIMD without impairing RBE.
Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in theCaenorhabditis elegansGermline”
Authors: Bradford Beatrix R , Briand Nicole E , Fassnacht Nina , Gervasio Esabelle D , Nowakowski Aidan M , FitzGibbon Theresa C , Maurina Stephanie , Benjamin Alexis V , Kelly MaryEllen , Checchi Paula M 
Published: December 2020

AbstractEnvironmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combating their harmful effects. Using the nematode Caenorhabditis elegans, a model with many genetic and physiological similarities to humans, researchers in the Colaiácovo laboratory have identified several molecular mechanisms by which the toxic agent bisphenol A (BPA) interferes with reproduction. Here, we address their recent discovery that a widely available compound, Coenzyme Q10 (CoQ10), can rescue BPA-induced damage. This work is significant in that it poses a low-cost method for improving reproductive success in humans. The goal of this primer is to assist educators and students with navigating the paper entitled “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline.” It is ideally suited for integration into an upper-level undergraduate course such as Genetics, Cell and Molecular Biology, Developmental Biology, or Toxicology. The primer provides background information on the history of BPA, the utility of the C. elegans germ line as a model for studying reproductive toxicity, and research methods including assessment of programmed cell death, fluorescent microscopy applications, and assays to quantify gene expression. Questions for deeper exploration in-class or online are provided.Related article in GENETICS: Hornos Carneiro MF, Shin N, Karthikraj R, Barbosa F Jr, Kannan K, Colaiácovo MP. Antioxidant CoQ10 restores fertility by rescuing bisphenol A-induced oxidative DNA damage in the Caenorhabditis elegans Germline. Genetics 214:381–395.
Neischnocolus iquitos, una especie nueva de Perú (Araneae: Theraphosidae: Theraphosinae)
Authors: Kaderka Radan 
Published: December 2020

Neischnocolus iquitos sp. nov. from Loreto region, Peru, is described, diagnosed and figured. Males of N. iquitos sp. nov. differ from all known congeners in the presence of two retrolateral processes on palpal tibia, in combination with the presence of a retrolateral keel on embolus and the absence of granulation or microspikes on embolus or tegulum. Females of N. iquitos sp. nov. differ from all known Neischnocolus females in the morphology of the genitalia consisting of a lower sclerotized part with two short, separate seminal receptacles, and an upper part, which is transparent and notched.
________________________________________________________________Publicación registrada en Zoobank/ZooBank article registered:LSIDurn:lsid:zoobank.org:pub:4854FB77-99B5-4208-9394-DBA7BB5EC64FActo nomenclatural/nomenclatural act:Neischnocolus iquitos Kaderka, 2020LSIDurn:lsid:zoobank.org:act:F5FB8A3E-922A-47AC-B5B2-B575C206B39D________________________________________________________________
SURVIVAL ASSESSMENT OF PATHOGENIC BACTERIA WITH ANTIBIOTIC RESISTANCE TRAITS FROM FRESH SUMMER ROYAL GRAPE: IN VITRO MICROBIAL CHALLENGE TEST
Authors: Akter Taslima , Shahriar Asif , Alo Mahenaj , Rahman Tasmina , Emran Talha Bin 
Published: December 2020

Table grape act as a popular and mouthwatering fruit supplement over the world. Unhygienic handling of these fruits can possess a diverse threat to public health safety. Moreover, the fruit juice can serve as a nutrient for bacterial growth as well if kept in an unsanitary condition. For this purpose, five imported grape samples (Red Globe, Perlette, Calmeria, Princess and Summer Royal) were tested to assess the presence of pathogenic bacteria and drug-resistant pattern of the isolates. The total bacterial count (TBC) and total fungal count (TFC) showed the presence large amount of bacterial (ranged from 4.4 x 104 to 8.1 x 107) and fungal population on the grapes samples, especially on the skin part of the fruits. Several pathogenic isolates, Escherichia coli, Staphylococcus spp., and Pseudomonas spp. were isolated from tested grape samples. However, the presence of Salmonella spp., Shigella spp., Vibrio spp. and Klebsiella spp. were not found from any of the samples. The concerning part of the present study was drug-resistant bacterial strains isolated from supplied Fresh Summer Royal Grape. The most of the isolated bacterial spp. were resistant to all most all of the commonly used antibiotics such as ampicillin (10 µg), trimethoprim/sulfamethoxazole (25 µg), tetracycline (30 µg), ceftriaxone (30 µg), imipenem (10 µg), chloramphenicol (30 µg), azithromycin (15 µg), novobiocin (30 µg), vancomycin (30 µg), penicillin G (10 µg), ciprofloxacin (5 µg), neomycin (30 µg), levofloxacin (5 µg), kanamycin (30 µg) and cefiximycin (5 µg). No grape samples showed any kind of antimicrobial activity against both pathogenic and non-pathogenic bacteria. The survival pattern of inoculated bacterial samples in the grape sample showed a slight decrease in growth in the course of time.
DETERMINATION OF ANTIOXIDANT, ANTI-AGING AND CYTOTOXICITY ACTIVITY OF THE ESSENTIAL OILS FROM CINNAMOMUM ZEYLANICUM
Authors: Wanakhachornkrai Oraphan , Banglao Warunya , Thongmee Acharawan , Sukplang Patamaporn 
Published: December 2020

Antioxidant activity, anti-aging effects and cytotoxicity activity of cinnamon essential oils from Cinnamomum zeylanicum were investigated in this study. The antioxidant activities of the cinnamon essential oil at the concentrations of 125, 250, 500, and 1000 µg/mL were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). The inhibitory activities against collagenase, elastase and tyrosinase were evaluated for anti-aging effects. The antioxidant activity determined by DPPH and ABTS assays varied from 4.91 - 28.74% and 4.96 - 50.17%, respectively. In addition, cinnamon essential oil at all concentrations tested (100, 200, 500, and 1000 µg/mL) inhibited tyrosinase activity by 61.68 - 93.12 %, collagenase activity by 2.83 - 30.28 % and elastase activity by 4.37 - 33.92 %. The cytotoxicity activity determined by the diphenyltetrazolium (MTT) assay revealed that the cinnamon essential oil at the concentration less than 100 µg/mL did not exhibit cytotoxicity activity on human fibroblast cells while the percentage of cell viability decreased when exposed to this oil at the concentration higher than 150 µg/mL. These results demonstrated that the cinnamon essential oil has antioxidant, tyrosinase inhibitory, collagenase inhibitory, and elastase inhibitory activities. In addition, cinnamon essential oil at each effective concentration did not show any toxicity when tested on normal human fibroblast cell. Therefore, this essential oil could be a potential candidate for cosmetic and pharmaceutical products.
Maize hybrid and nutrient specific evaluation of the population dynamics and damage of the western corn rootworm (Diabrotica Virgifera Virgifera LeConte) in a long-term field experiment
Authors: Illés Árpád , Bojtor Csaba , Mousavi Seyed Mohammad Nasir , Csaba Marton L. , Ragán Péter , Nagy János 
Published: December 2020

AbstractAgricultural production is threatened by different invasive species, as their damage results in a serious loss of income. The aim of the research was the assessment of the swarming dynamics and damage of the western corn rootworm (WCR) adults and larvae. The experiment was carried out in monoculture fertilization long-term experiments and three maize hybrids compared for their reaction against WCR adult and larval damage under non-infested plots at different nitrogen levels. Differences among the hybrids have a lower effect on the damage of corn rootworm adults and larvae than the amount of applied nitrogen. The phosphorus-potassium are optimal levels, while nitrogen ranges from 0 to 300 kg and no nutrient supply took place in the control plots for 30 years. The number of adults located and feeding on the styles of the female flower recorded and the damage caused on the roots by larvae ranked on a modified Iowa scale. Nitrogen fertilization resulted in a change in the silking time. The lowest root damage observed in the case of the high nutrient treatment with an Iowa value of 3.18. The coincidence of the nourishment of adults and the egg-laying time with silking is a potential threat in terms of fertility. Based on the results, it found that the extent of root damage can be reduced through the optimal selection of the time and dose of nutrient supply, primarily that of nitrogen. In general, both larvae and adults can cause severe yield loss, but the method of control against them is different. The coincidence of the nourishment of adults and the egg-laying time with silking is a potential threat in terms of fertility.
Optimization of extraction of phenolic compounds from Tokaji Aszú marc using response surface methodology
Authors: Bánvölgyi Szilvia , Dusza Eszter , Namukwambi Fiina K. , Kiss István , Stefanovits-Bányai Éva , Vatai Gyula 
Published: December 2020

AbstractSimilarly to other industries wineries also increasingly attempt to minimize and utilize waste to protect our environment. The aim of this study was to determine the optimal parameters (temperature, solvent concentration, and time) of extracting total polyphenol content (TPC) from Tokaji Aszú marc using two different extraction solvents: ethanol–water and isopropanol–water (1:4 solid/liquid ratio). The extractions were achieved based on Central Composite Design with Response Surface Method (CCRD–RSM). The optimal extraction parameters in the case of ethanol–water solvent: 60 °C temperature, 59.5% ethanol concentration in solvent, 5 h. At these parameters the probable TPC concentration is 23966.2 uM GAE/L. The optimal extraction parameters in the case of isopropanol–water solvent: 60 °C temperature, 52% ethanol concentration in solvent, 5 h. At these parameters the probable TPC concentration is 7188.44 uM GAE/L. In both cases the binary solvent was better than the mono-solvent. Ethanol–water solvent was more efficient than the isopropanol–water solvent.