bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal displacement of maxillary sinus anterior wall versus conventional sinus lift with lateral access: a 3-year retrospective Computerized Tomography study
Authors: Crespi Roberto , Toti Paolo , Covani Ugo , Brevi Carlo Bruno , Rubino Luigi , Preda Camilla , Esposito Francesca , Menchini-Fabris Giovanni-Battista 
Published: March 2020

Abstract
Background To compare a sinus augmentation procedure with a distal displacement of the anterior wall to a standard sinus lifting and grafting with a lateral window approach. Methods In the displacement group, a sinus surgical fracture results in the distal displacement of the anterior wall by means of an electromagnetic device. In the filling group, a sinus lifting with lateral access and grafting with particulate bone was performed. Bone volume beneath the maxillary sinus was investigated with Computerized Tomography after data superimposition. Clinical and radiological outcomes over 3 years had been evaluated. Results Forty-three dental implants were enrolled. The surgery of both groups significantly increased the bone volume in the VOIs (p-value≤0.0017) respectively for displacement group from 1.17±0.34cc to 1.53±0.39cc with a final bone volume gain of +0.36±0.17cc and for filling group from 1.24±0.41cc to 1.94±0.68cc with a bone augmentation of 0.71±0.31cc. Two implants early failed in the filling group, attesting the 3-year survival rate to 92.6%(CI95%: 82.7%-100%). Marginal bone loss at the distal aspect was 1.66±0.72mm and 1.25±0.78mm for displacement and filling group, respectively (p-value=0.0497). Conclusions The study showed an effective bone gain around dental implants at 3-year of survey both for sinus augmented by backward displacement of the anterior wall (+34%) and by sinus lifting with a lateral window approach (+57%).
Inhibition of a v b 3 integrin impairs adhesion and uptake of tumor-derived small extracellular vesicles
Authors: Altei Wanessa , Pachane Bianca , Santos Patty K. , Ribeiro Ligia , Sung Bong Hwan , Weaver Alissa , de Araújo Heloisa Sobreiro Selistre 
Published: March 2020

Abstract
Background: Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors are enriched in small EVs (SEVs) and SEV-carried integrins have been shown to promote cancer cell migration and to mediate organ-specific metastasis; however, how integrins mediate these effects is not entirely clear and could represent a combination of EV binding to extracellular matrix and cells.Methods: To probe integrin role in EVs binding and uptake, we employed a disintegrin inhibitor (DisBa-01) of integrin binding with specificity for avb3 integrin. EVs were purified from MDA-MB-231 cells conditioned media by serial centrifugation method. Isolated EVs were characterized by different techniques and further employed in adhesion, uptake and co-culture experiments.Results: We find that SEVs secreted from MDA-MB-231 breast cancer cells carry avb3 integrin and bind directly to fibronectin-coated plates, which is inhibited by DisBa-01. SEV coating on tissue culture plates also induces adhesion of MDA-MB-231 cells, which is inhibited by DisBa-01 treatment. Analysis of EV uptake and interchange between cells reveals that the amount of CD63-positive EVs delivered from malignant MDA-MB-231 breast cells to non-malignant MCF10A breast epithelial cells is reduced by DisBa-01 treatment. Inhibition of avb3 integrin decreases CD63 expression in cancer cells suggesting an effect on SEV content.Conclusion: In summary, our findings demonstrate for the first time a key role of avb3 integrin in cell-cell communication through SEVs.
The Role of p53-induced miR-145a in Senescence and Osteogenesis of Mesenchymal Stem Cells
Authors: Xia Chao , Jiang Tianyuan , Wang Yonghui , Chen Xiaoting , Hu Yan , Gao Yanhong 
Published: March 2020

Abstract
Background: The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is diminished. However, little is known about the mechanisms. p53 not only regulates cellular senescence but also, as a negative regulator, is involved in bone formation. This study investigated the molecular mechanism of p53 in cellular senescence and osteogenesis.Methods: The expression of p53 and its downstream gene p21 were measured during cellular senescence and osteogenesis differentiation of primary bone marrow MSCs. Then miR-145a was picked out from those p53-induced miRNAs as its expression change in bone marrow MSCs senescence and osteogenesis induced by H2O2 and BMP-9, respectively. The function of p53 induced miR-145a was analyzed by transfected with miRNA mimic in osteogenic differentiation of MSCs. Western blot and luciferase reporter assay were used for validating the target of miR-145a. Results: p53, its downstream effector p21, and p53-induced miR-145a were significantly upregulated during primary MSCs senescence and osteogenesis. Overexpression of miR-145a promoted cellular senescence and inhibited osteogenic differentiation of MSCs. p53-induced miR-145a inhibited osteogenic differentiation by targeting core binding factor beta (Cbfb), and the restoration of Cbfb expression rescued the inhibitory effects of miRNA-145a on osteogenesis.Conclusions: p53-induced miR-145a functions both in promoting senescence and inhibiting osteogenesis of MSCs, and the novel pathway p53/miR-145a/Cbfb in osteogenic differentiation of MSCs may represent new targets in the treatment of osteoporosis.
Shared genetic background between cerebrospinal fluid biomarkers and risk for Alzheimer’s disease: A two-sample Mendelian randomisation study
Authors: Kim Soyeon , Kim Kiwon , Nho Kwangsik , Myung Woojae , Won Hong-Hee 
Published: March 2020

Abstract
Background: Whether the epidemiological association of amyloid beta (Aβ) and tau pathology with Alzheimer’s disease (AD) is causal remains unclear. Recent failures to demonstrate the efficacy of several Aβ-modifying drugs may indicate a possibility that the observed association is not causal, which led to efforts to develop tau-directed treatments whose efficacy remains tentative. Methods: Herein, we conducted a two-sample Mendelian randomisation analysis to investigate shared genetic background between cerebrospinal fluid (CSF) biomarkers for amyloid and tau pathology and risk for AD, and to find genetic evidence for causal association between these CSF biomarkers and risk for AD. We used summary statistics of genome-wide association study (GWAS) for CSF biomarkers (Aβ 1-42 , phosphorylated tau 181 [p-tau], and total tau [t-tau]) in 3,146 individuals and for late-onset AD (LOAD) in 21,982 LOAD cases and 41,944 cognitively-normal controls. We tested association between changes in the genetically-predicted CSF biomarkers and LOAD risk. Results: We found a decrease in the LOAD risk per one-standard deviation (SD) increase in the genetically-predicted CSF Aβ (odds ratio [OR], 2.87×10 -3 for AD; 95% confidence interval [CI], 1.54×10 -4 –0.05; p = 8.91×10 -5 ). Conversely, we observed an increase in the LOAD risk per one-SD increase in the genetically-predicted CSF p-tau (OR, 19.46; 95% CI, 1.50–2.52×10 2 ; p = 0.02) and t-tau (OR, 33.80; 95% CI, 1.57–7.29×10 2 ; p = 0.02). Conclusions: Our findings suggest a shared genetic background between the CSF biomarkers and LOAD risk. Although it requires validation by future studies including more genetic variants identified in large-scale GWASs for CSF biomarkers, our results suggest a causal association between CSF biomarkers and risk for LOAD Keywords: CSF biomarkers, Amyloid, Tau, Alzheimer’s disease
The effect of socioeconomic status on informal caregiving intensity of adult females for parents: Evidence from a national study in China
Authors: Wang Yi , Li Jiajia , Ding Lulu , Feng Yuejing , Tang Xue , Sun Long , Zhou Chengchao 
Published: March 2020

Abstract
Background Few studies explored the effect of SES of caregivers on informal caregiving in China, especially from a female perspective. The purpose of this study was to empirically examine how the SES of female caregivers affects the amount of informal care they provide for parents in China. Methods The data used in this study was derived from the China Health and Nutrition Survey (CHNS). Informal caregivers were divided into three categories: non-caregivers (0 hrs/week), low-intensity caregivers (less than 10 hrs/week), and high-intensity caregivers (more than 10 hrs/week). Chi-square tests and one-way analysis of variance (ANOVA) were used to compare the SES of the women between non-, low-, and high-intensity caregivers. Multinomial logistic regression analysis was used to calculate relative risk ratios (RRR) for various SES variables to assess the relation of SES on the likelihood of a low- and high-intensity caregiving in the household, adjusting for age, marital status, family characteristics and wave. Results Of the 2741 respondents, high-intensity and low-intensity caregivers accounted for 16.42% and 21.38% respectively. Multinomial logistic regression results found that the likelihood of being a high-intensity caregiver vs. a non-caregivers increased as the caregiver’s education attainment increased. Urban females were 1.34 times more likely than their rural counterparts to provide low-intensity care vs. no care ( p <0.05) and were 1.34 times more likely to provide high-intensity care vs. no care ( p <0.05). Employed females were 1.27 times more likely than those non-employed to provide low-intensity care vs. no care ( p <0.05). Conclusions Differences in SES were found between high-intensity caregivers and low-intensity caregivers. Women with higher SES (higher education attainment, higher incomes, and urban Hukou ) were more likely to provide high-intensity informal care, and women who were employed and with urban Hukou were more likely to provide low-intensity care.
Factors Associated with the Quality of Life of Patients with Cancer Undergoing Radiotherapy
Authors: Kim Jun Won , Kang Dae Hun , Bong Su hyun , Seol Ki Ho 
Published: March 2020

Abstract
Background: Nearly half of cancer patients have comorbidities such as adjustment disorder, major depressive disorder, and delirium. Radiotherapy can cause psychological problems, e.g., the fear of treatment and its side effects, anxiety, depression, and social isolation. Determining health-related quality of life (QoL) is crucial for evaluating cancer treatment effectiveness. We analyzed the clinical, psychological, and sociodemographic factors influencing QoL in cancer patients undergoing radiotherapy.Methods: Twenty-six patients undergoing radiotherapy (10 male, 16 female) were included. Sociodemographic and clinical data were collected prior to radiotherapy. Psychosocial factors were assessed by self-reported questionnaires before, immediately after, and 3 months after radiotherapy. Multiple regression analysis identified factors affecting QoL at each time point.Results: Patients’ diagnoses were breast, cervical, prostate, endometrial, rectal, hypopharyngeal, laryngeal, liver, gallbladder, esophageal, ovarian, lung, and skin cancers. Before radiotherapy, better resilience was significantly associated with a higher QoL score (R2=0.199, p=0.033). Immediately after radiotherapy, financial difficulty was significantly associated with a lower QoL score (R2=0.274, p=0.010). Three months after radiotherapy, the presence of chronic disease (R2=0.398, p=0.002) and the severity of nausea and vomiting were significantly associated with a lower QoL score (R2=0.278, p=0.014).Conclusions: Resilience, financial difficulty, the presence of chronic diseases, and the severity of nausea and vomiting significantly influenced QoL in cancer patients undergoing radiotherapy. Factors affecting QoL varied at each time point. Thus, cancer patients should undergo regular mental health assessments, including QoL. Multidimensional (physical, psychological, and social) approaches and individualized time-based interventions are needed to improve the QoL of cancer patients undergoing radiotherapy.
<b>ANÁLISE DAS DIRETRIZES ESTRATÉGICAS USADAS PARA INCORPORAR A RESILIÊNCIA NOS PROCESSOS ORGANIZACIONAIS</b>
Authors: Ferreira Eliane Duarte , Nunes Fabiano Pamato , Santos Neri dos 
Published: March 2020

A capacidade das organizações para lidar com incertezas ambientais, ameaças, crises e acontecimentos inesperados depende da sua capacidade de resiliência. Este estudo analisa as diretrizes estratégicas usadas para incorporar resiliência em processos organizacionais. Trata-se de uma revisão sistemática da literatura, nas bases de dados Scopus, Web of Science e Scielo, nos últimos 5 anos com os descritores Resilience AND “knowledge management"; "organizational resilience” AND "knowledge management"; "organizational resilience” AND “organizational processes" foi realizada uma análise qualitativa dos 10 artigos considerados mais relevantes na pesquisa. Como resposta percebeu-se que as diretrizes variam conforme a expertise da organização e o seu propósito comercial, porém elementos como “fortalecer foco organizacional em estratégias de resposta”, “equilíbrio entre planejar e improvisar processos”, “estratégias da gestão do conhecimento em práticas de gestão de risco”, “capacidade de antecipação”, “adaptabilidade”, “troca de informação”, “compartilhamento do conhecimento”, “eficiência”, “eficácia” e “aprendizagem organizacional” são algumas diretrizes que precisam ser consideradas.Palavras-chave: Resiliência organizacional. Processos organizacionais. Gestão do Conhecimento.
<b>GESTÃO DO TRABALHO E O USO DE TICS</b>: um estudo de caso da implantação ERP CIGAM na gestão de serviços de sistemas de informação
Authors: De Moraes Oliveira Nicolas Marcos , Da Gama Laurentino William , Serpa Castor Emiliano Carlos , De Gouvêa Dantas Motta Ana Carolina 
Published: March 2020

Com o crescimento do segmento de serviços, as organizações têm se preocupado com o desenvolvimento de processos e mecanismos de controle capazes de gerenciar a forma de prestação de serviços aos seus clientes. Neste cenário, aplicam-se modelos e padrões como a metodologia ITIL® e políticas de CRM que norteiam as boas práticas, em diferentes tipos de organizações, capazes de gerenciar e controlar de maneira eficiente os serviços prestados e gerir a relação que a organização mantém com seus clientes. Esta pesquisa se debruçou sobre o processo de implantação do módulo de gestão de serviços de uma ferramenta ERP, englobando as metodologias referidas e possibilitando a interação com outras áreas de negócio relacionadas.Palavras-chave: Gestão do Trabalho. Gestão de Serviços. ITIL®. CRM. ERP.
Identifying Lung Cancer Risk Factors in the Elderly Using Deep Neural Networks: Quantitative Analysis of Web-Based Survey Data
Authors: Chen Songjing , Wu Sizhu 
Published: March 2020

Background
Lung cancer is one of the most dangerous malignant tumors, with the fastest-growing morbidity and mortality, especially in the elderly. With a rapid growth of the elderly population in recent years, lung cancer prevention and control are increasingly of fundamental importance, but are complicated by the fact that the pathogenesis of lung cancer is a complex process involving a variety of risk factors.

Objective
This study aimed at identifying key risk factors of lung cancer incidence in the elderly and quantitatively analyzing these risk factors’ degree of influence using a deep learning method.

Methods
Based on Web-based survey data, we integrated multidisciplinary risk factors, including behavioral risk factors, disease history factors, environmental factors, and demographic factors, and then preprocessed these integrated data. We trained deep neural network models in a stratified elderly population. We then extracted risk factors of lung cancer in the elderly and conducted quantitative analyses of the degree of influence using the deep neural network models.

Results
The proposed model quantitatively identified risk factors based on 235,673 adults. The proposed deep neural network models of 4 groups (age ≥65 years, women ≥65 years old, men ≥65 years old, and the whole population) achieved good performance in identifying lung cancer risk factors, with accuracy ranging from 0.927 (95% CI 0.223-0.525; P=.002) to 0.962 (95% CI 0.530-0.751; P=.002) and the area under curve ranging from 0.913 (95% CI 0.564-0.803) to 0.931(95% CI 0.499-0.593). Smoking frequency was the leading risk factor for lung cancer in men 65 years and older. Time since quitting and smoking at least 100 cigarettes in their lifetime were the main risk factors for lung cancer in women 65 years and older. Men 65 years and older had the highest lung cancer incidence among the stratified groups, particularly non–small cell lung cancer incidence. Lung cancer incidence decreased more obviously in men than in women with smoking rate decline.

Conclusions
This study demonstrated a quantitative method to identify risk factors of lung cancer in the elderly. The proposed models provided intervention indicators to prevent lung cancer, especially in older men. This approach might be used as a risk factor identification tool to apply in other cancers and help physicians make decisions on cancer prevention.
AN OVERVIEW OF ANALYTICAL METHOD VALIDATION
Authors: BESKAN Umut , YILDIRIM Sümeyra TUNA , YAPAR Evren ALGIN 
Published: March 2020

In line with the developments in the pharmaceutical field, the product range is constantly being renewed and diversified. New analytical techniques need to be developed and validated for new pharmaceutical products. The validation of an improved method is an internationally recognized scientific requirement, as these validation practices are also indicative of the competence of the analytical laboratory. The method development is a process that ensures the applicability and reliability of the data. The result is a more comprehensive understanding of the standard test methods and a further insight into the connection between test methodology and product quality. It is important to validate an advanced method. Because if the method can not be reproduced, the method is meaningless. Validation is a continuous balance among costs, risks and technical possibilities.
Peer Review History:
Received 5 February 2020; Revised 22 February; Accepted 1 March, Available online 15 March 2020
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewer(s) detail:
Name: Kian Navaee
Affiliation: Shahre Daru Pharmaceutical Co., Iran
E-mail: kian.navaee@chemist.com

Name: Dr. Mohammad Shaheen Khan
Affiliation: University Malaysia Sabah, Malaysia
E-mail: shaheenchem@gmail.com
Comments of reviewer(s):

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Authors: Laasanen Mikko 
Published: March 2020

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On the critique of the Saussurean concept of language: some perspectives and counter-arguments
The article deals with the critique of the Saussurean concept of language. The purpose of the article is to defend the Saussurean concept of language and to present Saussure as a more versatile thinker than may be assumed from a purely structuralist reading of Course. The article discusses the concept of language as a system (Saussure’s langue), the notion of context-free meaning, the so-called written-language bias, Roy Harris’ language myth, and the notion of dynamicity in language in relation to the Saussurean concept of language. The article begins by arguing that langue is both a methodological and an ontological concept that refers both to the unorganised rules of language and to the system of language rules as organised by the linguist. Second, the author asserts that some kind of permanence of meaning is essential to the concept of language as a communication system. Third, an argument is presented against the strong form of written-language bias, according to which, for instance, the analysis and reduction of continuous speech into discrete units is based on the model of written language. Fourth, the author posits that the language myth, developed by Harris, is not based on Saussure’s views but on Harris’ interpretation of Saussure’s views. The article ends with the contention that the notion of dynamicity is not incompatible with the Saussurean concept of language.
Keskusteluntutkijoiden kooste vuoronalkuisista partikkeleista
Authors: Raitaniemi Mia 
Published: March 2020

Arvioitu teos:
John Heritage & Marja-Leena Sorjonen (toim.): Between turn and sequence. Turninitial particles across languages. Studies in Language and Social Interaction 31. Amsterdam: John Benjamins 2018. 487 s. isbn 978-90-272-0048-8.