bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthogonal pulsars as a key test for pulsar evolution
Authors: Novoselov E M , Beskin V S , Galishnikova A K , Rashkovetskyi M M , Biryukov A V 
Published: April 2020

ABSTRACT
At present, there is no direct information about evolution of inclination angle χ between magnetic and rotational axes in radio pulsars. As to theoretical models of pulsar evolution, they predict both the alignment, i.e. evolution of inclination angle χ to 0°, and its counter-alignment, i.e. evolution to 90°. In this paper, we demonstrate that the statistics of interpulse pulsars can give us the key test to solve the alignment/counter-alignment problem as the number of orthogonal interpulse pulsars (χ ≈ 90°) drastically depends on the evolution trajectory.
Differential rotation in neutron stars with open and closed magnetic topologies
Authors: Anzuini F , Melatos A 
Published: April 2020

ABSTRACT
Analytic arguments have been advanced that the degree of differential rotation in a neutron star depends on whether the topology of the internal magnetic field is open or closed. To test this assertion, the ideal-magnetohydrodynamics solver pluto is employed to investigate numerically the flow of an incompressible, viscous fluid threaded by a magnetic field with open and closed topologies in a conducting, differentially rotating, spherical shell. Rigid body corotation with the outer sphere is enforced on the Alfvén time-scale, along magnetic field lines that connect the northern and southern hemispheres of the outer sphere. Along other field lines, however, the behaviour is more complicated. For example, an initial point dipole field evolves to produce an approximately closed equatorial flux tube containing at least one predominantly toroidal and approximately closed field line surrounded by a bundle of predominantly toroidal but open field lines. Inside the equatorial flux tube, the field-line-averaged magnetic tension approaches zero, and the fluid rotates differentially, adjusting its angular velocity on the viscous time-scale to match the boundary conditions on the flux tube’s toroidal surface. Outside the equatorial flux tube, the differential rotation increases, as the magnetic tension averaged along open field lines decreases.
Quantifying torque from the Milky Way bar using Gaia DR2
Authors: Kipper Rain , Tenjes Peeter , Tuvikene Taavi , Ganeshaiah Veena Punyakoti , Tempel Elmo 
Published: April 2020

ABSTRACT
We determine the mass of the Milky Way bar and the torque it causes, using Gaia DR2, by applying the orbital arc method. Based on this, we have found that the gravitational acceleration is not directed towards the centre of our Galaxy but a few degrees away from it. We propose that the tangential acceleration component is caused by the bar of the Galaxy. Calculations based on our model suggest that the torque experienced by the region around the Sun is $\approx 2400\, {\rm km^2\, s^{-2}}$ per solar mass. The mass estimate for the bar is $\sim 1.6\pm 0.3\times 10^{10}\, \mathrm{M_\odot }$. Using greatly improved data from Gaia DR2, we have computed the acceleration field to great accuracy by adapting the orbital Probability Density Function (oPDF) method (Han et al. 2016) locally and used the phase space coordinates of ∼4 × 105 stars within a distance of 0.5 kpc from the Sun. In the orbital arc method, the first step is to guess an acceleration field and then reconstruct the stellar orbits using this acceleration for all the stars within a specified region. Next, the stars are redistributed along orbits to check if the overall phase space distribution has changed. We repeat this process until we find an acceleration field that results in a new phase space distribution that is the same as the one that we started with; we have then recovered the true underlying acceleration.
Galactic outflow rates in the EAGLE simulations
Authors: Mitchell Peter D , Schaye Joop , Bower Richard G , Crain Robert A 
Published: April 2020

ABSTRACT
We present measurements of galactic outflow rates from the eagle suite of cosmological simulations. We find that gas is removed from the interstellar medium (ISM) of central galaxies with a dimensionless mass loading factor that scales approximately with circular velocity as $V_{\mathrm{c}}^{-3/2}$ in the low-mass regime where stellar feedback dominates. Feedback from active galactic nuclei causes an upturn in the mass loading for halo masses ${\gt}10^{12} \, \mathrm{M_\odot }$. We find that more gas outflows through the halo virial radius than is removed from the ISM of galaxies, particularly at low redshifts, implying substantial mass loading within the circumgalactic medium. Outflow velocities span a wide range at a given halo mass/redshift, and on average increase positively with redshift and halo mass up to $M_{200} \sim 10^{12} \, \mathrm{M_\odot }$. Outflows exhibit a bimodal flow pattern on circumgalactic scales, aligned with the galactic minor axis. We present a number of like-for-like comparisons to outflow rates from other recent cosmological hydrodynamical simulations, and show that comparing the propagation of galactic winds as a function of radius reveals substantial discrepancies between different models. Relative to some other simulations, eagle favours a scenario for stellar feedback where agreement with the galaxy stellar mass function is achieved by removing smaller amounts of gas from the ISM, but with galactic winds that then propagate and entrain ambient gas out to larger radii.
Extraordinary Sequence Diversity and Promiscuity of Centromeric Satellites in the Legume Tribe Fabeae
Authors: Ávila Robledillo Laura , Neumann Pavel , Koblížková Andrea , Novák Petr , Vrbová Iva , Macas Jiří 
Published: April 2020

Abstract
Satellite repeats are major sequence constituents of centromeres in many plant and animal species. Within a species, a single family of satellite sequences typically occupies centromeres of all chromosomes and is absent from other parts of the genome. Due to their common origin, sequence similarities exist among the centromere-specific satellites in related species. Here, we report a remarkably different pattern of centromere evolution in the plant tribe Fabeae, which includes genera Pisum, Lathyrus, Vicia, and Lens. By immunoprecipitation of centromeric chromatin with CENH3 antibodies, we identified and characterized a large and diverse set of 64 families of centromeric satellites in 14 species. These families differed in their nucleotide sequence, monomer length (33–2,979 bp), and abundance in individual species. Most families were species-specific, and most species possessed multiple (2–12) satellites in their centromeres. Some of the repeats that were shared by several species exhibited promiscuous patterns of centromere association, being located within CENH3 chromatin in some species, but apart from the centromeres in others. Moreover, FISH experiments revealed that the same family could assume centromeric and noncentromeric positions even within a single species. Taken together, these findings suggest that Fabeae centromeres are not shaped by the coevolution of a single centromeric satellite with its interacting CENH3 proteins, as proposed by the centromere drive model. This conclusion is also supported by the absence of pervasive adaptive evolution of CENH3 sequences retrieved from Fabeae species.
rMAPS2: an update of the RNA map analysis and plotting server for alternative splicing regulation
Authors: Hwang Jae Y , Jung Sungbo , Kook Tae L , Rouchka Eric C , Bok Jinwoong , Park Juw W 
Published: April 2020

Abstract
The rMAPS2 (RNA Map Analysis and Plotting Server 2) web server, freely available at http://rmaps.cecsresearch.org/, has provided the high-throughput sequencing data research community with curated tools for the identification of RNA binding protein sites. rMAPS2 analyzes differential alternative splicing or CLIP peak data obtained from high-throughput sequencing data analysis tools like MISO, rMATS, Piranha, PIPE-CLIP and PARalyzer, and then, graphically displays enriched RNA-binding protein target sites. The initial release of rMAPS focused only on the most common alternative splicing event, skipped exon or exon skipping. However, there was a high demand for the analysis of other major types of alternative splicing events, especially for retained intron events since this is the most common type of alternative splicing in plants, such as Arabidopsis thaliana. Here, we expanded the implementation of rMAPS2 to facilitate analyses for all five major types of alternative splicing events: skipped exon, mutually exclusive exons, alternative 5′ splice site, alternative 3′ splice site and retained intron. In addition, by employing multi-threading, rMAPS2 has vastly improved the user experience with significant reductions in running time, ∼3.5 min for the analysis of all five major alternative splicing types at once.
EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes
Authors: Wu Di , Dean Jurrien 
Published: April 2020

AbstractGrowing mammalian oocytes accumulate substantial amounts of RNA, most of which is degraded during subsequent meiotic maturation. The growth-to-maturation transition begins with germinal vesicle or nuclear envelope breakdown (GVBD) and is critical for oocyte quality and early development. The molecular machinery responsible for the oocyte transcriptome transition remains unclear. Here, we report that an exosome-associated RNase, EXOSC10, sculpts the transcriptome to facilitate the growth-to-maturation transition of mouse oocytes. We establish an oocyte-specific conditional knockout of Exosc10 in mice using CRISPR/Cas9 which results in female subfertility due to delayed GVBD. By performing multiple single oocyte RNA-seq, we document dysregulation of several types of RNA, and the mRNAs that encode proteins important for endomembrane trafficking and meiotic cell cycle. As expected, EXOSC10-depleted oocytes have impaired endomembrane components including endosomes, lysosomes, endoplasmic reticulum and Golgi. In addition, CDK1 fails to activate, possibly due to persistent WEE1 activity, which blocks lamina phosphorylation and disassembly. Moreover, we identified rRNA processing defects that cause higher percentage of developmentally incompetent oocytes after EXOSC10 depletion. Collectively, we propose that EXOSC10 promotes normal growth-to-maturation transition in mouse oocytes by sculpting the transcriptome to degrade RNAs encoding growth-phase factors and, thus, support the maturation phase of oogenesis.
Design and Physical Properties of 3-Dimensional Printed Models Used for Neurointervention: A Systematic Review of the Literature
Authors: Waqas Muhammad , Mokin Maxim , Lim Jaims , Vakharia Kunal , Springer Michael E , Meess Karen M , Ducharme Richard W , Ionita Ciprian N , Nagesh Swetadri Vasan Setlur , Gutierrez Liza C , Snyder Kenneth V , Davies Jason M , Levy Elad I , Siddiqui Adnan H 
Published: April 2020

Abstract

Background
Three-dimensional (3D) printing has revolutionized training, education, and device testing. Understanding the design and physical properties of 3D-printed models is important.

Objective
To systematically review the design, physical properties, accuracy, and experimental outcomes of 3D-printed vascular models used in neurointervention.

Methods
We conducted a systematic review of the literature between January 1, 2000 and September 30, 2018. Public/Publisher MEDLINE (PubMed), Web of Science, Compendex, Cochrane, and Inspec databases were searched using Medical Subject Heading terms for design and physical attributes of 3D-printed models for neurointervention. Information on design and physical properties like compliance, lubricity, flow system, accuracy, and outcome measures were collected.

Results
A total of 23 articles were included. Nine studies described 3D-printed models for stroke intervention. Tango Plus (Stratasys) was the most common material used to develop these models. Four studies described a population-representative geometry model. All other studies reported patient-specific vascular geometry. Eight studies reported complete reconstruction of the circle of Willis, anterior, and posterior circulation. Four studies reported a model with extracranial vasculature. One prototype study reported compliance and lubricity. Reported circulation systems included manual flushing, programmable pistons, peristaltic, and pulsatile pumps. Outcomes included thrombolysis in cerebral infarction, post-thrombectomy flow restoration, surgical performance, and qualitative feedback.

Conclusion
Variations exist in the material, design, and extent of reconstruction of vasculature of 3D-printed models. There is a need for objective characterization of 3D-printed vascular models. We propose the development of population representative 3D-printed models for skill improvement or device testing.
Analysis of niche characteristics of phytoplankton functional groups in fluvial ecosystems
Authors: Nagy-László Zsolt , Padisák Judit , Borics Gábor , Abonyi András , B-Béres Viktória , Várbíró Gábor 
Published: April 2020

AbstractAssigning species to functional response groups in phytoplankton ecology reduces the number of functional units, which helps understand the processes that shape diversity and functioning of planktonic assemblages. Although the concept has become widespread in recent years, numerical characterization of the groups’ positions in the niche space remained a challenging task. Using a large river phytoplankton dataset, we characterized the functional groups (FGs) of phytoplankton by their niche position and niche breadth in the niche space defined by the relevant environmental variables using the Outlying Main Index approach. The niche space has been defined primarily by trophic-related (nutrients) and river size-related variables (water residence time, discharge). Although we hypothesized that FGs with central niche position would have wide, while those with marginal niche position have narrow niche breadth, these have not been corroborated by the results. Rather, FGs occurred both with central niche position and intermediate breadth, as well as with marginal niche position and wide breadth. Niche position of several FGs was different from that suggested by their known habitat templates in lakes. Furthermore, we found no significant relationship between niche position and niche breadth, suggesting that the occurrence of FGs in rivers is simultaneously influenced by both niche characteristics.
Diuretic lounge and the impact on hospital admissions for treatment of decompensated heart failure
Authors: Ioannou A , Browne T , Jordan S , Metaxa S , Mandal A K J , Missouris C G 
Published: April 2020

Abstract

Background
Heart failure is a prevalent condition associated with frequent and costly hospital admissions. Hospitalizations are primarily related to worsening fluid retention and often require admission for decongestion with intravenous diuretics.

Objective
To assess the safety of an outpatient intravenous diuresis service for heart failure patients, and its impact on emergency admissions and the cost of treatment.

Methods
We conducted a prospective observational cohort registry study on patients referred to the diuretic lounge at our acute hospital between May 2017 and April 2018.

Results
We analysed 245 patients treated in the diuretic lounge, of which 190 (77.6%) avoided hospitalization or any adverse events during the 60 days of follow up (77.6% vs. 22.4%; P &lt; 0.001). The diuretic lounge service resulted in a significant decrease in emergency heart failure admissions compared to the previous 12 months (823 vs. 715 per annum; 68.6 ± 10.1 vs. 59.6 ± 14 per month; P = 0.04), and a numerical reduction in readmission rates (17.3% vs. 16.2%). The 13.1% decrease in admissions lead to financial savings of £315 497 per annum and £2921 per admission avoided. During the same time period, at the other acute hospital site in our trust, where no diuretic lounge service is available, the number of admissions did not significantly change (457 vs. 450 per annum; 37.5 ± 7.0 vs. 38.1 ± 7.6 per month; P = 0.81).

Conclusion
Ambulatory administration of intravenous diuretics reduces emergency admissions and is a safe and cost-effective alternative to treat acute decomposition in heart failure patients.
How Do Executives Exercise Their Stock Options?*
Authors: Klein Daniel , Maug Ernst 
Published: April 2020

Abstract
We analyze how 14,000 top U.S. executives exercise their stock options. Factors suggested by existing theories have low or moderate explanatory power. Variables that model executives’ motive to diversify fare particularly poorly, whereas variables that capture reference-dependent preference, such as past highs and lows of stock prices, perform better. By contrast, characteristics of option portfolios are of first-order importance and suggest that managers have target ownership levels. Institutional features like vesting restrictions or blackout periods also have a first-order impact. We conclude that executives’ main motivations for exercising stock options early seem to be outside the scope of extant models. (JEL G30, M52)
Received August 20, 2018; editorial decision December 28, 2019 by Editor Andrew Ellul.
Pattern similarity and connectivity of hippocampal-neocortical regions support empathy for pain
Authors: Wagner Isabella C , Rütgen Markus , Lamm Claus 
Published: April 2020

Abstract
Empathy is thought to engage mental simulation, which in turn is known to rely on hippocampal-neocortical processing. Here, we tested how hippocampal-neocortical pattern similarity and connectivity contributed to pain empathy. Using this approach, we analyzed a data set of 102 human participants who underwent functional MRI while painful and non-painful electrical stimulation was delivered to themselves or to a confederate. As hypothesized, results revealed increased pattern similarity between first-hand pain and pain empathy (compared to non-painful control conditions) within the hippocampus, retrosplenial cortex, the temporo-parietal junction and anterior insula. While representations in these regions were unaffected by confederate similarity, pattern similarity in the dorsal medial prefrontal cortex was increased the more dissimilar the other individual was perceived. Hippocampal-neocortical connectivity during first-hand pain and pain empathy engaged largely distinct but neighboring primary motor regions, and empathy-related hippocampal coupling with the fusiform gyrus positively scaled with trait measures of perspective taking. These findings suggest that shared representations and mental simulation might contribute to pain empathy via hippocampal-neocortical pattern similarity and connectivity, partially affected by personality traits and the similarity of the observed individual.
Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice
Authors: Tonello Raquel , Xie Wenrui , Lee Sang Hoon , Wang Min , Liu Xiaojuan , Strong Judith A. , Zhang Jun-Ming , Berta Temugin 
Published: April 2020

Abstract

Background
Patients undergoing cancer treatment often experience chemotherapy-induced neuropathic pain at their extremities, for which there is no U.S. Food and Drug Administration–approved drug. The authors hypothesized that local sympathetic blockade, which is used in the clinic to treat various pain conditions, can also be effective to treat chemotherapy-induced neuropathic pain.

Methods
A local sympathectomy (i.e., cutting the ipsilateral gray rami entering the spinal nerves near the L3 and L4 dorsal root ganglia) was performed in mice receiving intraperitoneal injections every other day of the chemotherapeutic drug paclitaxel. Sympathectomy effects were then assessed in chemotherapy-induced pain-like behaviors (i.e., mechanical and cold allodynia) and neuroimmune and electrophysiologic responses.

Results
Local microsympathectomy produced a fast recovery from mechanical allodynia (mean ± SD: sympathectomy vs. sham at day 5, 1.07 ± 0.34 g vs. 0.51 ± 0.17g, n = 5, P = 0.030 in male mice, and 1.08 ± 0.28 g vs. 0.62 ± 0.16 g, n = 5, P = 0.036 in female mice) and prevented the development of cold allodynia in both male and female mice after paclitaxel. Mechanistically, microsympathectomy induced transcriptional increases in dorsal root ganglia of macrophage markers and anti-inflammatory cytokines, such as the transforming growth factor-β. Accordingly, depletion of monocytes/macrophages and blockade of transforming growth factor-β signaling reversed the relief of mechanical allodynia by microsympathectomy. In particular, exogenous transforming growth factor-β was sufficient to relieve mechanical allodynia after paclitaxel (transforming growth factor-β 100 ng/site vs. vehicle at 3 h, 1.21 ± 0.34g vs. 0.53 ± 0.14 g, n = 5, P = 0.001 in male mice), and transforming growth factor-β signaling regulated neuronal activity in dorsal root ganglia.

Conclusions
Local sympathetic nerves control the progression of immune responses in dorsal root ganglia and pain-like behaviors in mice after paclitaxel, raising the possibility that clinical strategies already in use for local sympathetic blockade may also offer an effective treatment for patients experiencing chemotherapy-induced neuropathic pain.

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New
Accuracy and Feasibility of Clinically Applied Frailty Instruments before Surgery
Authors: Aucoin Sylvie D. , Hao Mike , Sohi Raman , Shaw Julia , Bentov Itay , Walker David , McIsaac Daniel I. 
Published: April 2020

Background
A barrier to routine preoperative frailty assessment is the large number of frailty instruments described. Previous systematic reviews estimate the association of frailty with outcomes, but none have evaluated outcomes at the individual instrument level or specific to clinical assessment of frailty, which must combine accuracy with feasibility to support clinical practice.

Methods
The authors conducted a preregistered systematic review (CRD42019107551) of studies prospectively applying a frailty instrument in a clinical setting before surgery. Medline, Excerpta Medica Database, Cochrane Library and the Comprehensive Index to Nursing and Allied Health Literature, and Cochrane databases were searched using a peer-reviewed strategy. All stages of the review were completed in duplicate. The primary outcome was mortality and secondary outcomes reflected routinely collected and patient-centered measures; feasibility measures were also collected. Effect estimates were pooled using random-effects models or narratively synthesized. Risk of bias was assessed.

Results
Seventy studies were included; 45 contributed to meta-analyses. Frailty was defined using 35 different instruments; five were meta-analyzed, with the Fried Phenotype having the largest number of studies. Most strongly associated with: mortality and nonfavorable discharge was the Clinical Frailty Scale (odds ratio, 4.89; 95% CI, 1.83 to 13.05 and odds ratio, 6.31; 95% CI, 4.00 to 9.94, respectively); complications was associated with the Edmonton Frail Scale (odds ratio, 2.93; 95% CI, 1.52 to 5.65); and delirium was associated with the Frailty Phenotype (odds ratio, 3.79; 95% CI, 1.75 to 8.22). The Clinical Frailty Scale had the highest reported measures of feasibility.

Conclusions
Clinicians should consider accuracy and feasibility when choosing a frailty instrument. Strong evidence in both domains support the Clinical Frailty Scale, while the Fried Phenotype may require a trade-off of accuracy with lower feasibility.

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New