bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between HLA-DRB1* allele polymorphism and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region
Authors: Wang Liping , Li Boqi , Tie Xiaomin , Liu Tao , Zheng Shutao , Liu Yishan 
Published: December 2019

Objective The rate of caries and the mean number of decayed, missing, or filled teeth were reported to be significantly higher in children in the Xinjiang Uygur Autonomous Region than in children in eastern China. Little is known regarding the genetic basis of caries among residents of the Xinjiang Uygur Autonomous Region. This study investigated the association between HLA-DRB1 alleles and caries susceptibility in Han Chinese children and adolescents in the Xinjiang Uygur Autonomous Region. Methods HLA-DRB1 allele frequency was assessed in DNA samples from buccal swabs of 42 patients with caries and 123 healthy control participants using a polymerase chain reaction method with sequence-specific primers. The chi-squared test or Fisher’s exact test, followed by Bonferroni correction, was used to calculate differences in allele frequencies between groups. Results Compared with the healthy controls, the allele frequency of HLA-DRB1*13 was significantly higher in patients with caries in the Xinjiang Uygur Autonomous Region (35.71% vs. 18.70%). The allele frequency of HLA-DRB1* 09 was significantly lower in patients with caries than in healthy controls (4.76% vs. 25.20%). Conclusions HLA-DRB1* 13 alleles could confer greater caries susceptibility, whereas HLA-DRB1* 09 could be protective against caries pathogenesis, in Han Chinese children in the Xinjiang Uygur Autonomous Region.
Prospective Randomized Comparison of Capsular Management Techniques During Hip Arthroscopy
Authors: Economopoulos Kostas J. , Chhabra Anikar , Kweon Christopher 
Published: December 2019

Background: Capsular management during hip arthroscopy remains controversial. Studies evaluating this topic consist mostly of retrospective comparative reviews of prospectively gathered data on a large series of patients. Purpose/Hypothesis: The purpose was to perform a prospective randomized trial to comparatively assess 3 commonly performed capsular management techniques. It was hypothesized that capsular closure during hip arthroscopy would result in superior outcomes when compared with unclosed capsulotomy management techniques. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Patients (N = 150) who had hip arthroscopy with labral repairs and femoral osteoplasties performed by the senior author were randomly assigned into 3 groups at the time of their surgery: T-capsulotomy without closure (TC), interportal capsulotomy without closure (IC), and interportal capsulotomy with closure (CC). All patients underwent labral repair and femoral osteoplasty. Patient-reported outcomes were obtained preoperatively and at 3, 6, 12, and 24 months postoperatively. Other outcomes obtained included the need for future hip surgery. Results: Patient demographics, preoperative patient-reported outcomes, and radiographic measurements were similar among all 3 groups. Revision hip arthroscopy was performed in 5 TC cases, 2 IC cases, and 1 CC case ( P = .17). Conversion to hip arthroplasty occurred in 4 patients in the TC group and none in the IC and CC groups ( P = .02). The CC group showed higher modified Harris Hip Score (mHHS) and Hip Outcome Score–Activities of Daily Living (HOS-ADL) at the 2-year follow-up when compared with the IC group ( P = .003 and P < .001, respectively). When compared with the TC group, the CC group demonstrated superior mHHS (86.2 vs 76), HOS-ADL (85.6 vs 76.8), and HOS-SSS (Hip Outcome Score–Sports-Specific Subscale; 74.4 vs 65.3) at the final 2-year follow-up ( P < .001). At the 2-year follow-up, the IC group had a higher mHHS (81.7 vs 76), HOS-ADL (82 vs 76.8), and HOS-SSS (71.4 vs 65.3; P > .001) as compared with the TC group. Conclusion: Patients undergoing complete capsular closure during hip arthroscopy showed improved patient-reported and surgical outcomes when compared with those with unrepaired T-capsulotomy or interportal capsulotomy. These results suggest that repair after capsulotomy may be a favorable arthroscopic capsular management technique.
Tragedy Following Tragedies: Estimating the Copycat Effect of Media-Covered Suicide in the Age of Digital News
Authors: Ownby Daniel , Routon P. Wesley 
Published: December 2019

The Werther effect is the name given to the observed relationship between celebrity suicide and the national suicide rate. Media-covered suicides are often followed by a positive shock in the national suicide rate. Using a unique time series comprising media coverage variables collected from Google News and major news websites, combined with several U.S. national trends from various sources, we estimate the magnitude of the Werther effect in the age of digital news media, where news of celebrity suicide spreads farther and more rapidly. We find a speeding up of this effect, which in the last century was only observed in the month following news coverage. Now, the effect appears slightly more prominent in the month of coverage, though it still persists in the following month. We also find evidence that the Werther effect has diminished in magnitude, perhaps due to the increased normalization of both suicide and celebrity suicide. JEL Classifications: Z13, Z19, I19
Country-level Governance and Capital Markets in Asia-Pacific Region
Authors: Duppati Geeta , Scrimgeour Frank , Kumar Anoop S. 
Published: December 2019

Manuscript type: An empirical analysis of the relationship between country-level governance and share markets in the Asia-Pacific region was carried out using dynamic value at risk (Dynamic VaR), mixed data sample (MIDAS) and exponential generalised autoregressive conditional heteroskedasticity (EGARCH) models. Research question/issue: Is there a relationship between a country’s governance and stock market in terms of the level of returns and share price volatility? We hypothesise that stock returns for countries with higher levels of governance will have lower ex ante expected returns and less volatility than countries with lower levels of governance. Research findings/insights: It is evident from the empirical findings that there is still significant diversity in both corporate-level governance and country-level governance within the Asia-Pacific region. The results from using mixed data sample-autoregressive distributed lag (MIDAS-ADL) model correlation between world governance index (WGI) and the dynamic VaR suggest that the estimators of high frequency slope for India, China and Malaysia are negative. In addition, their t statistics show that the correlation is significant; meanwhile, their goodness of fit is also very high confirming the explanation power of MIDAS-AD model. Consequently, the capital market performances of India, China and Malaysia are negatively related to their corporate-level governance and country-level governance. However, China has a positive correlation between WGI and corporate-level governance and country-level governance. This uncommon phenomenon may be the result of its special political system and the segregation of the capital market and the real economy. Theoretical/academic implications: The linkage between country-level governance and volatility of stocks in Asia-Pacific markets indicates there is scope to reduce stock price volatility through enhanced national governance. Volatility as an indicator of risk reflects market uncertainty in terms of processing information signals to find the equilibrium return risk nexus. Consequently, researchers have to incorporate the data of different frequency into the same equation using robust methods. Practitioner/policy implications: Regulatory frameworks encompassing stock markets will benefit from a more focussed consideration of the way in which governance and risk are correlated. Findings from the generalised autoregressive conditional heteroskedasticity (GARCH) and VaR analysis are that stock market volatility is a suitable proxy for the governance of a country. As country governance indices are annual at best, volatility measures give more timely readings. An increase in volatility suggests there is a decline in national governance, and this has implications for those involved in trade, donor organisations and international lending agencies such as the World Bank.
Double region of interest timing bolus technique following endovascular aortic repair: Short-term prognosis analysis
Authors: Tomizawa Nobuo , Ito Shingo , Nakao Tastuya , Arakawa Hiroaki , Yamamoto Kodai , Inoh Shinichi , Nojo Takeshi , Nakamura Sunao 
Published: December 2019

Objectives To compare the incidence rate of reintervention in patients with and without complication findings at aortic computed tomography using double region of interest timing bolus (DRTB) method after endovascular stent placement of the aorta. Methods We included 40 patients who underwent computed tomography of the aorta using DRTB method after endovascular stent placement. DRTB method allows to scan the aorta with a short injection time of 9 s by synchronizing the scan speed to the aortic flow. Complication findings at computed tomography were defined as endoleak, rupture, occlusion, and infection. The primary endpoint was reintervention, which was defined as any of the following three events: conversion to open repair, graft revision, or secondary intervention. Results The mean contrast medium during computed tomography angiography was 38.6 ± 3.9 mL. Complication findings at computed tomography were present in 10 patients (25%): endoleak ( n = 9) and infection ( n = 1). During a median follow-up of 7 months (interquartile range, 4–11 months), two patients experienced reintervention. Kaplan–Meier curves by complication findings showed that event rate at 6 months was significantly higher in patients with complication findings than in patients without (20% vs 0%, p =  0.01). No patients without complication findings at computed tomography experienced reintervention. Conclusions No complication findings at computed tomography after intervention of the aorta resulted in good prognosis in patients who underwent aortic computed tomography using DRTB method.
Water Cartographies of Goa: Khazans, Sedimentation and Dissolution of Coastal Cultural Landscapes
Authors: Pombo Pedro 
Published: December 2019

Goa’s landscape is an encounter between dry and wet materialities, the Indian Ocean world and the Western Ghats of Konkan, the distant and the localized, open seas and deep currents and floodplains, estuaries and muddy soils. Reordered in geometric geographies, these curvilineous cultivated lowlands, named khazans, surrounded by villages, temples and churches are part of the landscape and crucial sensorial layers of this Indian state. Village neighbourhoods (named waddi in Konkani) are organized not around a solid centre, but along several interconnected paddy fields, creating particular territorial maps of each village. Can our perception change, thus, if we see the Goan territory having water as its defining element, instead of a land-based perspective, and consider these lands as cultural landscapes? The aesthetic and heritage dimensions of cultural landscapes are essential to perceive Goa as a place of simultaneous dissolution and sedimentation along time and cultural geographies. Based on recent research on Goa and the Indian Ocean, this text proposes khazans to be recognized both as natural elements and cultural signifiers and as the main cartographic layers of inclusive Goan cultural landscapes.
HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material
Authors: Ottestad William , Rognes Ingrid N. , Skaga Erlend , Frisvoll Cassandra , Haraldsen Guttorm , Eken Torsten , Lundbäck Peter 
Published: December 2019

Abstract
Background
HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, despite that pre-analytical conditions account for a substantial part of the overall error rate in laboratory testing. We hypothesized that the considerable variations in reported HMGB1 concentrations and kinetics in trauma patients could be partly explained by differences in pre-analytical conditions and choice of sample material.

Methods
Trauma patients (n = 21) admitted to a Norwegian Level I trauma center were prospectively included. Blood was drawn in K2EDTA coated tubes and serum tubes. The effects of delayed centrifugation were evaluated in samples stored at room temperature for 15 min, 3, 6, 12, and 24 h respectively. Plasma samples subjected to long-term storage in − 80 °C and to repeated freeze/thaw cycles were compared with previously analyzed samples. HMGB1 concentrations in simultaneously acquired arterial and venous samples were also compared. HMGB1 was assessed by standard ELISA technique, additionally we investigated the suitability of western blot in both serum and plasma samples.

Results
Arterial HMGB1 concentrations were consistently lower than venous concentrations in simultaneously obtained samples (arterial = 0.60 x venous; 95% CI 0.30–0.90). Concentrations in plasma and serum showed a strong linear correlation, however wide limits of agreement. Storage of blood samples at room temperature prior to centrifugation resulted in an exponential increase in plasma concentrations after ≈6 h. HMGB1 concentrations were fairly stable in centrifuged plasma samples subjected to long-term storage and freeze/thaw cycles. We were not able to detect HMGB1 in either serum or plasma from our trauma patients using western blotting.

Conclusions
Arterial and venous HMGB1 concentrations cannot be directly compared, and concentration values in plasma and serum must be compared with caution due to wide limits of agreement. Although HMGB1 levels in clinical samples from trauma patients are fairly stable, strict adherence to a pre-analytical protocol is advisable in order to protect sample integrity. Surprisingly, we were unable to detect HMGB1 utilizing standard western blot analysis.
Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study
Authors: So-Armah Kaku , Freiberg Matthew , Cheng Debbie , Lim Joseph K. , Gnatienko Natalia , Patts Gregory , Doyle Margaret , Fuster Daniel , Lioznov Dmitry , Krupitsky Evgeny , Samet Jeffrey 
Published: December 2019

Abstract
Background
The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to poor outcomes. The liver regulates innate immunity and adaptive immune tolerance. HIV-infected people have high prevalence of liver-related comorbidities. We hypothesize that advanced liver fibrosis/cirrhosis is associated with alterations in T-cell subsets consistent with immunosenescence.

Methods
ART-naïve people with HIV with a recent history of heavy drinking were recruited into a clinical trial of zinc supplementation. Flow cytometry was used to characterize T-cell subsets. The two primary dependent variables were CD8+ and CD4+ T-cells expressing CD28-CD57+ (senescent cell phenotype). Secondary dependent variables were CD8+ and CD4+ T-cells expressing CD45RO + CD45RA- (memory phenotype), CD45RO-CD45RA+ (naïve phenotype), and the naïve phenotype to memory phenotype T-cell ratio (lower ratios associated with immunosenescence). Advanced liver fibrosis/cirrhosis was defined as FIB-4 > 3.25, APRI≥1.5, or Fibroscan measurement ≥10.5 kPa. Analyses were conducted using multiple linear regression adjusted for potential confounders.

Results
Mean age was 34 years; 25% female; 88% hepatitis C. Those with advanced liver fibrosis/cirrhosis (N = 25) had higher HIV-1 RNA and more hepatitis C. Advanced liver fibrosis/cirrhosis was not significantly associated with primary or secondary outcomes in adjusted analyses.

Conclusions
Advanced liver fibrosis/cirrhosis was not significantly associated with these senescent T-cell phenotypes in this exploratory study of recent drinkers with HIV. Future studies should assess whether liver fibrosis among those with HIV viral suppression and more advanced, longstanding liver disease is associated with changes in these and other potentially senescent T-cell subsets.
HIV screening in men and women in Senegal: coverage and associated factors; analysis of the 2017 demographic and health survey
Authors: Lakhe Ndeye Aïssatou , Diallo Mbaye Khardiata , Sylla Khadime , Ndour Cheikh Tidiane 
Published: December 2019

AbstractBackgroundDespite the adoption of the provider-initiated HIV testing strategy, the rate of HIV testing is still very low in sub-Saharan Africa. The aim of this study was to assess the factors associated with HIV testing among sexually active women and men in Senegal. Knowledge of HIV status is the gateway to antiretroviral treatment.MethodsA secondary analysis of the 2017 Senegal Demographic and Health Survey (DHS) was performed, using data on sexually active women aged 15–49 and men aged 15–59. The outcome variable was the proportion of women and men who reported ever being tested for HIV in the last 12 months before the survey. Descriptive, bivariate, and multivariable logistic regression analyses were performed to identify the socio-demographic, HIV-knowledge, media exposure, and behavioral factors associated with HIV testing in Senegal.ResultsThe study found that 61.1% (95%CI: 59.2–62.9) of women and 26.2% (95%CI: 24.2–28.3) of men were tested for HIV at the last 12 months. In multivariate analysis, among men the factors independently associated with being tested for HIV were: age groups 20–24 to 40–44 and age group 50–54; a higher level of education; being in the richest household wealth quintile; being married; knowing about the efficacy of HAART during pregnancy; having 2 or more lifetime sex partners and owning a mobile phone. Among women factors independently associated with HIV testing were: being in any age groups versus 15–19; a higher level of education; being in the richest household wealth quintile; being married; knowing about the efficacy of HAART during pregnancy; having any STI in last 12 months; fearing stigma; owning a mobile phone; and having any number of ANC visits, versus none.ConclusionAlthough HIV remains a public health threat, HIV testing’s prevalence is still low in Senegal, making it difficult to interrupt the transmission chain within the community and to reach the UNAIDS goal for 2020 of “90–90-90”. Innovative community-based strategies are needed to address barriers and improve access to HIV testing in Senegal, particularly for men and for the youngest and poorest populations.
Burden of acute kidney injury and 90-day mortality in critically ill patients
Authors: Wiersema Renske , Eck Ruben J. , Haapio Mikko , Koeze Jacqueline , Poukkanen Meri , Keus Frederik , van der Horst Iwan C. C. , Pettilä Ville , Vaara Suvi T. 
Published: December 2019

Abstract
Background
Mortality rates associated with acute kidney injury (AKI) vary among critically ill patients. Outcomes are often not corrected for severity or duration of AKI. Our objective was to analyse whether a new variable, AKI burden, would outperform 1) presence of AKI, 2) highest AKI stage, or 3) AKI duration in predicting 90-day mortality.

Methods
Kidney Diseases: Improving Global Outcomes (KDIGO) criteria using creatinine, urine output and renal replacement therapy were used to diagnose AKI. AKI burden was defined as AKI stage multiplied with the number of days that each stage was present (maximum five), divided by the maximum possible score yielding a proportion. The AKI burden as a predictor of 90-day mortality was assessed in two independent cohorts (Finnish Acute Kidney Injury, FINNAKI and Simple Intensive Care Studies I, SICS-I) by comparing four multivariate logistic regression models that respectively incorporated either the presence of AKI, the highest AKI stage, the duration of AKI, or the AKI burden.

Results
In the FINNAKI cohort 1096 of 2809 patients (39%) had AKI and 90-day mortality of the cohort was 23%. Median AKI burden was 0.17 (IQR 0.07–0.50), 1.0 being the maximum. The model including AKI burden (area under the receiver operator curve (AUROC) 0.78, 0.76–0.80) outperformed the models using AKI presence (AUROC 0.77, 0.75–0.79, p = 0.026) or AKI severity (AUROC 0.77, 0.75–0.79, p = 0.012), but not AKI duration (AUROC 0.77, 0.75–0.79, p = 0.06). In the SICS-I, 603 of 1075 patients (56%) had AKI and 90-day mortality was 28%. Median AKI burden was 0.19 (IQR 0.08–0.46). The model using AKI burden performed better (AUROC 0.77, 0.74–0.80) than the models using AKI presence (AUROC 0.75, 0.71–0.78, p = 0.001), AKI severity (AUROC 0.76, 0.72–0.79. p = 0.008) or AKI duration (AUROC 0.76, 0.73–0.79, p = 0.009).

Conclusion
AKI burden, which appreciates both severity and duration of AKI, was superior to using only presence or the highest stage of AKI in predicting 90-day mortality. Using AKI burden or other more granular methods may be helpful in future epidemiological studies of AKI.
The ED50 and ED95 of oxytocin infusion rate for maintaining uterine tone during elective caesarean delivery: a dose-finding study
Authors: Qian Xiao Wei , Drzymalski Dan M. , Lv Chang Cheng , Guo Fei He , Wang Lu Yang , Chen Xin Zhong 
Published: December 2019

Abstract
Background
The 90% effective dose (ED90) of oxytocin infusion has been previously estimated to be 16.2 IU h− 1. However, bolus administration of oxytocin prior to the infusion may decrease the infusion dose required. The aim of this study was to estimate the ED95 for oxytocin infusion after a bolus at elective caesarean delivery (CD) in nonlaboring parturients.

Methods
We performed a randomized, triple blinded study in 150 healthy termparturients scheduled for elective CD under epidural anaesthesia. After delivery of the infant and i.v. administration of 1 IU oxytocin as a bolus, Participants were randomized to receive oxytocin infusion at a rate of 0, 1, 2, 3, 5, or 8 IU h− 1, to be given for a total of 1 h. Uterine tone assessed by the blinded obstetrician as either adequate or inadequate. Secondary outcomes included estimated blood loss (EBL), requirement for supplemental uterotonic agents, and development of side effects.

Results
The 95% effective dose (ED95) of oxytocin infusion was estimated to be 7.72 IU h− 1 (95% confidence interval 5.80–12.67 IU h− 1). With increasing oxytocin infusion rate, the proportion of parturients who needed rescue oxytocin bolus or secondary uterotonic agents decreased. No significant among-group differences in the EBL and oxytocin-related side effects were observed.

Conclusions
In parturients who receive a 1 IU bolus of oxytocin during elective cesarean delivery, an infusion rate of oxytocin at 7.72 IU h− 1 will produce adequate uterine tone in 95% of parturients. These results suggest that the total dose of oxytocin administered in the postpartum period can be decreased when administered as an infusion after oxytocin bolus.