bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Brief Analysis of Peptide-combined Nanoparticle: Nanomedicine’s Unique Value
Authors: Wang Jiemin , Wu Junyong , Li Yongjiang , Wen Jing , Cai Jiaxin , Tang Tiantian , Hu Xiongbin , Xiang Daxiong 
Published: February 2020

:
Therapeutic peptides (TPs) are biological macromolecules which can act as neurotransmitters,
hormones, ion channel ligands and growth factors. Undoubtedly, TPs are crucial in modern medicine.
But low bio-stability and some special adverse reactions reduce their places to the application.

:
With the development of nanotechnology, nanoparticles (NPs) in pharmaceutical science gained much
attention. They can encapsulate the TPs into their membrane or shell. Therefore, they can protect the
TPs against degradation and then increase the bioavailability, which was thought to be the biggest
advantage of them. Additionally, targeting was also studied to improve the effect of TPs. However,
there were some drawbacks of nano TPs like low loading efficiency and difficulty to manufacture.

:
Nowadays, lots of studies focused on improving effect of TPs by preparing nanoparticles. In this review,
we presented a brief analysis of peptide-combined nanoparticles. Their advantages and disadvantages
were listed in terms of mechanism. And several examples of applications were summarized.
ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors
Authors: de Paula Gonzaga Ana Luiza Ataide Carneiro , Palmeira Vitória Andrade , Ribeiro Thomas Felipe Silva , Costa Larissa Braga , de Sá Rodrigues Karla Emília , Simões-e-Silva Ana Cristina 
Published: February 2020

Background:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin II and AT1 receptor and the alternative axis composed by ACE2, Angiotensin-(1-7) and Mas receptor, have been investigated in cancer.Objective:This review aimed to summarize the pathophysiological role of RAS in cancer, evidence for anti-tumor effects of ACE2/Angiotensin-(1-7)/Mas receptor axis and future therapeutic perspectives for pediatric cancer.Methods:Pubmed, Scopus and Scielo were searched in regard to RAS molecules in human cancer and pediatric patients. The search terms were “RAS”, “ACE”, “Angiotensin-(1-7)”, “ACE2”, “Angiotensin II”, “AT1 receptor”, “Mas receptor”, “Pediatric”, “Cancer”.Results:Experimental studies have shown that Angiotensin-(1-7) inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer. Clinical trials with Angiotensin-( 1-7) or TXA127, a pharmaceutical grade formulation of the naturally occurring peptide, have reported promising findings, but not enough to recommend medical use in human cancer. In regard to pediatric cancer, only three articles that marginally investigated RAS components were found and none of them evaluated molecules of the alternative RAS axis.Conclusion:Despite the potential applicability of Angiotensin-(1-7) in pediatric tumors, the role of this molecule was never tested. Further clinical trials are necessary, also including pediatric patients, to confirm safety and efficiency and to define therapeutic targets.
DNA Sequence Analysis of BlaVEB Gene Encoding Multi-drug Resistant and Extended-spectrum β-lactamases Producer Isolates of Enterobacteriaceae and Pseudomonas aeruginosa
Authors: Al-Ouqaili Mushtak T.S. , Khalaf Eman A. , Al-Kubaisy Shaymaa H. 
Published: February 2020

Objective:
Multi-drug resistance Gram-negative bacteria possessing Extended-Spectrum β-Lactamase (ESBL) genes are of concern because of their resistance to third-generation cephalosporins. This study aims to investigate the molecular basis of resistance to modern β-lactams by ESBLs encoded by the blaVEB gene and the gene’s role in resistance. Also, gene sequencing was used to compare genetic similarities with global isolates using phylogenetic and cluster analyses.

Methods:
Between March and July 2018, a total of 100 Iraqi clinical isolates were examined, in this cross-sectional study, to determine their ESBL status using the double-disc synergy technique. Polymerase Chain Reactions (PCRs) were performed on extracted blaVEB genes and sequencing of the target PCR products was performed. All blaVEB sequences were compared with the available sequence data, using BLAST searches against the GenBank database.

Results:
A total of 35 isolates, comprising 5 Escherichia coli, 18 Klebsiella pneumoniae, and 12 Pseudomonas aeruginosa isolates were confirmed to possess ESBLs; the blaVEB gene was detected in one isolate of each species. The sequencing of these genes revealed 99% similarity with the global standard genes deposited in GenBank.

Conclusion:
The blaVEB gene plays an essential role in the resistance of ESBL-producing isolates to new β-lactams. Further, the sequencing and phylogenetic analyses of the genes from the P. aeruginosa, K. pneumonia, and E. coli isolates revealed 99% similarity with the GenBank global standard genes.
Formulation and Evaluation of DHA Oil based Nicotinamide Nanoemulsion Gel for Treating Atopic Dermatitis
Authors: Pradeep Gayathri P. , Viswanad Vidya 
Published: February 2020

Background:Atopic dermatitis (or eczema) can be defined as a chronic inflammatory condition accompanied by severe pruritus.Objective:The prepared gel was evaluated for in vitro drug release, in vitro occlusion studies, transepidermal water loss studies, skin permeation studies, in vitro skin irritation studies and antiinflammatory cell line studies.Methods:In vitro drug release studies were performed using Franz diffusion cells. The in vitro occlusion studies were carried out by the procedure reported by Wissing et al. TEWL determination was done by the method proposed by Reiger. The skin permeation studies were carried out using porcine skin using Franz diffusion cells. In vitro skin irritation study was carried out using HETCAM (Hen’s Egg Test on the Chorioallantoic Membrane) method. Anti-inflammatory cell line studies were carried out using RAW 264.7 cell lines.Results:In vitro drug release studies,drug release of nicotinamide from nanoemulsion gel was found to be more than marketed gel. Kinetic modelling showed a higuchi model with non-fickian diffusion. In vitro occlusion study showed the percentage of evaporated water from prepared nanoemulsion formulation after 72 h is very less compared with the other formulations. The TEWL measurement shows the reduction in TEWL has more in prepared nanoemulsion gel than other formulations. Anti-inflammatory cell line studies proved that the nanoemulsion gel has inhibition capacity on COX activity, LOX activity, Inducibe nitric oxide synthase and cellular nitrate levels.Conclusion:DHA oil based nicotinamidenanoemulsion gel were prepared successfully and the evaluation of prepared gel showed better drug release and skin permeation with better antiinflammatory activity.
Cervical Vertebra Tractor: Current Status and Future Perspectives
Authors: Jiang Jingang , Qian Wei , Huang Zhiyuan , Zhang Yongde , Chen Houjun , Song Shichang 
Published: February 2020

Background:
According to "The World's Top Ten Chronic Diseases" published by the
World Health Organization (WHO), Cervical Spondylosis, ranked second, has afflicted more youngsters
and the number is still growing because of the popularity of smart devices and long-term office
work. Surgical treatment is an invasive method with certain harm; in contrast, traction therapy, as a
conservative treatment, can effectively relieve neck pain and oppressed nerves, which is widely accepted
by doctors and patients. How to effectively guide and implement traction therapy has become a
research hotspot in the field of cervical rehabilitation.

Objective:
To provide an overview of the existing cervical vertebra tractors and introduce their classification,
characteristics, and development.

Methods:
This paper reviews the principles of traction therapy and various patents related to the cervical
vertebra tractor. The structural characteristics, differentiations, and applications of existing cervical
vertebra tractors are also introduced.

Results:
The existing cervical vertebra tractors are analyzed and compared, and the typical characteristics
are concluded. The main problems in its development are analyzed, the development trend is foreseen,
and the current and future research of the productions and patents on the cervical vertebra tractor
are discussed.

Conclusion:
The cervical vertebra tractor is divided into a sitting and supine device according to the
application of traction postural. The device can relieve the nerve, blood vessel, and spinal cord, relieve
pain, and quickly relieve the symptoms of cervical spondylosis. However, the current treatment device
exerts single axial traction, and the normal physiological curvature of the human cervical vertebra is
similar to the shape of "C", which is not conducive to maintaining normal physiological curvature.
Penguatan nilai-nilai Pancasila di sekolah dasar
Authors: Triyanto Triyanto , Fadhilah Nur 
Published: February 2020

Penelitian ini didasarkan pada pentingnya penguatan nilai Pancasila pada peserta didik di era digital saat ini. Tujuan penelitian ini adalah untuk mengetahui: 1) Bagaimana penguatan nilai-nilai Pancasila di SD; 2) Apa saja kendala untuk memperkuat nilai-nilai Pancasila di SD. Penelitian ini menggunakan penelitian kualitatif. Data dikumpulkan melalui studi pustaka, observasi dan wawancara. Subjek penelitian adalah kepala sekolah, guru, siswa. Hasil penelitian menunjukkan bahwa: 1) Pelaksanaan penguatan nilai-nilai Pancasila di SD termasuk dalam jalur sosialisasi Pancasila melalui pengembangan sosial budaya (psyco-paedagogial development) yang dilakukan melalui sholat berjamaah, pemilihan ketua kelas, diskusi kelompok kecil, pramuka, pembelajaran di kelas, jumat bersih, upacara bendera dan piket kelas. Pelaksanan penguatan nilai-nilai Pancasila di sekolah dasar menemui kendala yaitu sikap anak yang sulit dinasehati dan memiliki kebiasaan di luar sekolah yang kurang baik. Terdapat perubahan sikap dari anti sosial menjadi sikap peduli sosial. Hal ini sangat penting untuk menguatkan nilai-nilai Pancasila.---------------------------------------------------------Strengthening Pancasila values in elementary schoolsThis research is based on the importance of strengthening Pancasila values in students in today's digital era. The purpose of this study was to find out: 1) How to strengthen Pancasila values in elementary schools; 2) What are the obstacles to strengthening Pancasila values in elementary school. This study uses qualitative research. Data was collected through literature studies, observation, and interviews. The research subjects were principals, teachers, students. The results showed that: 1) The implementation of strengthening Pancasila values in elementary schools was included in the path of Pancasila socialization through socio-cultural development (psico-pedagogical development) carried out through congregational prayer, the election of class leaders, small group discussions, scouts, classroom learning, clean Friday, class ceremony and class picket. The implementation of strengthening Pancasila values in elementary schools has encountered obstacles, namely the attitude of children that is difficult to advise and has bad habits outside of school. There is a change in attitude from anti-social to social caring attitude. This is very important to strengthen Pancasila values.
Adoption of an Electronic Patient Record Sharing Pilot Project: Cross-Sectional Survey
Authors: Wang Jingxuan , Huang Junjie , Cheung Clement Shek Kei , Wong Wing Nam , Cheung Ngai Tseung , Wong Martin CS 
Published: February 2020

Background
The Public Private Interface–Electronic Patient Record (PPI-ePR) system was implemented as a new electronic platform to facilitate collaboration between the public and private sectors in Hong Kong. However, its barriers to participate and benefits have not been comprehensively assessed.

Objective
This study aimed to evaluate the awareness, acceptance, perceived benefits, and obstacles to participation among private doctors and the general public.

Methods
From December 2012 to January 2013, 2435 telephone interviews were performed by trained interviewers to survey randomly selected patients who were enrolled or not enrolled in the PPI-ePR system. In addition, self-administered surveys were sent by postal mail to 4229 registered doctors in Hong Kong. The questionnaires for both patients and doctors contained questions on subjects’ awareness, acceptance, and perceptions of the PPI-ePR, perceived benefits and obstacles of participating in the program, reasons for not using the system after enrolling, and perceived areas for service improvement of the system.

Results
More than 53.1% (266/501) of enrolled patients believed that the PPI-ePR system would improve health care quality by reducing duplicate tests and treatments, while more than 76.8% (314/409) of enrolled doctors emphasized timely access to patients’ medical records as the biggest benefit of their enrollment. Among nonenrolled patients, unawareness of the project was the most popular obstacle to enrolling in the PPI-ePR system (483/1200, 40.3%). Regarding nonenrolled doctors, the complicated registration process hindered them from participating in the program the most (95/198, 48.0%). Television, newspaper, and magazine advertisements and medical profession newsletters or journals were suggested as the most effective means to encourage participation in the program among surveyed patients (1297/1701, 76.2%) and doctors (428/610, 70.2%), respectively. Lack of clinical indication requiring data extraction from other hospitals was the main reason for low level of PPI-ePR use.

Conclusions
This study comprehensively assessed the popularity, perceived benefits, and hindering factors of enrolling in the PPI-ePR system in Hong Kong. Low levels of awareness, few privacy concerns, and inactive use of the PPI-ePR system were among the key features for patients and physicians. Public promotions, simplified logistics, and a user-friendly online interface were suggested to improve the coverage and effectiveness of health information exchange between private and public health care sectors.
Toward Continuous Social Phenotyping: Analyzing Gaze Patterns in an Emotion Recognition Task for Children With Autism Through Wearable Smart Glasses
Authors: Nag Anish , Haber Nick , Voss Catalin , Tamura Serena , Daniels Jena , Ma Jeffrey , Chiang Bryan , Ramachandran Shasta , Schwartz Jessey , Winograd Terry , Feinstein Carl , Wall Dennis P 
Published: February 2020

Background
Several studies have shown that facial attention differs in children with autism. Measuring eye gaze and emotion recognition in children with autism is challenging, as standard clinical assessments must be delivered in clinical settings by a trained clinician. Wearable technologies may be able to bring eye gaze and emotion recognition into natural social interactions and settings.

Objective
This study aimed to test: (1) the feasibility of tracking gaze using wearable smart glasses during a facial expression recognition task and (2) the ability of these gaze-tracking data, together with facial expression recognition responses, to distinguish children with autism from neurotypical controls (NCs).

Methods
We compared the eye gaze and emotion recognition patterns of 16 children with autism spectrum disorder (ASD) and 17 children without ASD via wearable smart glasses fitted with a custom eye tracker. Children identified static facial expressions of images presented on a computer screen along with nonsocial distractors while wearing Google Glass and the eye tracker. Faces were presented in three trials, during one of which children received feedback in the form of the correct classification. We employed hybrid human-labeling and computer vision–enabled methods for pupil tracking and world–gaze translation calibration. We analyzed the impact of gaze and emotion recognition features in a prediction task aiming to distinguish children with ASD from NC participants.

Results
Gaze and emotion recognition patterns enabled the training of a classifier that distinguished ASD and NC groups. However, it was unable to significantly outperform other classifiers that used only age and gender features, suggesting that further work is necessary to disentangle these effects.

Conclusions
Although wearable smart glasses show promise in identifying subtle differences in gaze tracking and emotion recognition patterns in children with and without ASD, the present form factor and data do not allow for these differences to be reliably exploited by machine learning systems. Resolving these challenges will be an important step toward continuous tracking of the ASD phenotype.
The Role of Psychological Factors in Older Adults’ Readiness to Use eHealth Technology: Cross-Sectional Questionnaire Study
Authors: Knapova Lenka , Klocek Adam , Elavsky Steriani 
Published: February 2020

BackgroundInformation and communication technology (ICT) use among older adults has been on the rise in recent years. However, the predictors and mechanisms behind older adults’ acceptance and use of ICT are not clear.ObjectiveThis study aimed to systematically describe ICT usage among Czech older adults and to evaluate the factors influencing their ICT use and readiness to use digital technology to promote health (eHealth readiness). The primary focus was on psychological factors and the role of persons close to older adults.MethodsThe research utilized cross-sectional survey data from a quota-based sample of Czech older adults (>50 years) and persons close to them further referred to as close persons (N=250 dyads). A structural equation modeling framework was used to evaluate relationships between psychological factors, ICT use, and eHealth readiness.ResultsCzech older adults’ use of ICT is low with the exception of cell phone usage (cell phone usage by 173/250, 69.2%; other devices used by 50/250, 20.0% of older adults or less). Apart from age (β=−.21; P<.001), eHealth readiness was predicted by ICT use (β=.65; P<.001). eHealth readiness was also indirectly affected by the need for cognitive closure (NFCC): individuals with a high need for closure perceived more barriers to ICT (β=.23; P=.01) and more reported barriers were linked to lower ICT usage (β=−.21; P=.001). The expected positive relationships between eHealth readiness of persons close to older adults and ICT use and eHealth readiness of older adults were not significant, but the total effect of eHealth readiness of persons close to older adults on eHealth readiness of older adults was positive and significant (β=.18; P=.01), indicating some level of influence of persons close to them on older adults’ attitudes and behaviors.ConclusionsThis study provided the first systematic examination of Czech older adults’ ICT usage and eHealth readiness. Novel predictors (NFCC and close persons’ variables) were evaluated and yielded actionable results. More research is needed to clarify the role of persons close to older adults.
Families’ Degree of Satisfaction With Pediatric Telehomecare: Interventional Prospective Pilot Study in Catalonia
Authors: López Seguí Francesc , Batlle Boada Astrid , García García Juan José , López Ulldemolins Ana , Achotegui del Arco Ane , Adroher Mas Cristina , García Cuyàs Francesc 
Published: February 2020

Background
Pediatric home hospitalization improves the quality of life of children and their families, involving them in their children’s care, while favoring the work-life balance of the family. In this context, technology guarantees accessibility to assistance, which provides security to users. From the perspective of the health care system, this could lower the demand for hospital services and reduce hospitalization costs.

Objective
This study aimed to assess families’ degree of satisfaction and acceptability of pediatric telehomecare and explore the clinical characteristics of children benefiting from the program.

Methods
A total of 95 children and their families participated in the home-hospitalization pilot program operated by Sant Joan de Déu Hospital in Barcelona, Spain. Families were visited once a day and patients were monitored using a kit consisting of a scale, a thermometer, a pulse oximeter, and a blood pressure monitor. Data on parental experience, satisfaction, safety, and preference for care was collected by means of a questionnaire. Data about the children’s characteristics were collected from medical records. Descriptive and comparative statistics were used to analyze the data.

Results
A total of 65 survey respondents expressed very high levels of satisfaction. Families reported their experiences as being very positive, preferring home hospitalization in 94% (61/65) of cases, and gave high scores regarding the use of telemonitoring devices. The program did not record any readmissions after 72 hours and reported a very low number of adverse incidents. The user profile was very heterogeneous, highlighting a large number of respiratory patients and patients with infections that required endovenous antibiotic therapy.

Conclusions
Pediatric home hospitalization through telemonitoring is a feasible and desirable alternative to traditional hospitalization, both from the perspective of families and the hospital. The results of this analysis showed a very high degree of satisfaction with the care received and that the home-based telemonitoring system resulted in few adverse incidents.
PROFILE OF COGNITIVE STRUCTURE OF STUDENTS IN UNDERSTANDING THE CONCEPT OF REAL ANALYSIS
Authors: Widada Wahyu 
Published: February 2020

The purpose of this research is to describe proil cognitive structure of students in understanding the concept of real analysis. This research is part of the research development of the theory of cognitive structure of students Mathematics Education Program at the University of Bengkulu. The results of this research are: 1)there are seven models decompositions of genetic students mathematics education reviewed based on the SRP Model about the concepts of Real Analysis namely Pra-Intra Level, Level intra, Level semi-inter, Level inter, Level semi-trans, Trans Level, level and Extended-Trans (only theoretic level while empirically not found); 2) There are six models decompositions of genetic students mathematics education reviewed based on KA about the concepts of Real Analysis namely Level 0: Objects of concrete steps; Level 1: Models Semi-concrete steps; Level 2: Models Theoretic; Level 3: Language in Domain Example; Level 4: Mathematical Language; Level 5: Inferensi Model. Profile of cognitive structure of mathematics education student at the University of Bengkulu is 6.25% Students located on the Basic Level (Pra-Intra Level with concrete objects), there is 8.75% Students located at Level 0 (intra Level with concrete objects), there are 15,00% Students located at Level 1 (semi-Level inter with Semi-Concrete Model), there are 33.75 percent students located on Level 2 (Level inter with theoretical model), there are 22.50 percent students located at Level 3 (Semi-trans Level with the Bible in Domain example), there are located on the student percent during the Level 4 (Trans Level with the language of Mathematics), and there are 0 percent students located at Level 5 (Level Extended-Trans with Inferensi Model). Students Education Mathematics at the University of Bengkulu pembangunnya element is functional can achieve Trans Level, students will be able to set up activities and make the algorithm that formed the concept/principles with the right. Functional students can also perform the process of abstraction using the rules in a system of mathematics.