bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of a randomized controlled trial with five-year radiostereometric analysis results of vitamin E-infused highly crosslinked versus moderately crosslinked polyethylene in reverse total hip arthroplasty
Authors: Thoen Peder S. , Nordsletten Lars , Pripp Are H. , Röhrl Stephan M. 
Published: November 2020

Aims Vitamin E-infused highly crosslinked polyethylene (VEPE) has been introduced into total hip arthroplasty (THA) with the aim of further improving the wear characteristics of moderately and highly crosslinked polyethylenes (ModXLPE and HXLPE). There are few studies analyzing the outcomes of vitamin E-infused components in cemented arthroplasty, though early acetabular component migration has been reported. The aim of this study was to measure five-year polyethylene wear and acetabular component stability of a cemented VEPE acetabular component compared with a ModXLPE cemented acetabular component. Methods In a prospective randomized controlled trial (RCT), we assessed polyethylene wear and acetabular component stability (primary outcome) with radiostereometric analysis (RSA) in 68 patients with reverse hybrid THA at five years follow-up. Patients were randomized to either a VEPE or a ModXLPE cemented acetabular component. Results Mean polyethylene wear in the proximal direction was 0.17 mm (SD 0.15) for the VEPE group and 0.20 mm (SD 0.09) for the ModXLPE group (p = 0.005) at five years. Annual proximal wear rates were 0.03 mm/year (VEPE) and 0.04 mm/year (ModXLPE). Total 3D wear was 0.21 mm (SD 0.26) and 0.23 mm (SD 0.10) for the VEPE and ModXLPE groups, respectively (p = 0.009). Total 3D cup translation was 0.72 mm (SD 0.70) (VEPE) and 0.50 mm (SD 0.44) (ModXLPE) (p = 0.409). Conclusion At five years, there was less polyethylene wear in the VEPE group than in the ModXLPE group. Both VEPE and ModXLPE cemented components showed low annual wear rates. Component stability was similar in the two groups and remained constant up to five years. Whether these results will equate to a lower long-term revision rate is still unknown. Cite this article: Bone Joint J 2020;102-B(12):1646–1653.
Impact of gas dynamics on laser filamentation THz sources at high repetition rates
Authors: Koulouklidis Anastasios D. , Lanara Christina , Daskalaki Christina , Fedorov Vladimir Yu. , Tzortzakis Stelios 
Published: November 2020

We experimentally demonstrate that the terahertz (THz) emission from two-color laser filaments in gases is strongly affected by the pulse repetition rate of the driving laser. We show that at repetition rates above 100 Hz, propagation of every next laser pulse in the pulse train is altered by gas density depressions produced by the preceding laser pulses. As a result, plasma channels at higher repetition rates become shorter, leading to less efficient THz generation. In particular, we observe a 50% decrease in the emitted THz energy when the repetition rate increases from 6 Hz to 6 kHz.
Mach–Zehnder silicon-photonic switch with low random phase errors
Authors: Song Lijia , Li Huan , Dai Daoxin 
Published: November 2020

A Mach–Zehnder silicon photonic switch with low random phase errors is proposed and demonstrated for the first time, to the best of our knowledge, by incorporating judiciously widened and shortened phase shifter waveguides. With a 180 nm complementary metal–oxide–semiconductor (CMOS) foundry process, more than one hundred

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thermo-optic Mach–Zehnder switches (MZSs) with varied phase shifter widths have been designed, fabricated, and characterized on 14 silicon chips. The mean and standard deviation of the random phase errors of the MZSs with phase shifters widened to 2 µm are less than a third of those of the conventional design with 0.45-µm-wide single-mode phase shifters. This validates the improved fabrication tolerance and results in considerable reduction of the power consumption for the phase error compensation. Such elegant methodology paves the way to further scaling up

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silicon thermo-optic switches and can be generalized for other phase-sensitive integrated photonic devices as well.
Levels of and changes in socioeconomic inequality in delivery care service: A decomposition analysis using Bangladesh Demographic Health Surveys
Authors: Pulok Mohammad Habibullah , Chirwa Gowokani Chijere , Novignon Jacob , Aizawa Toshiaki , Makate Marshall 
Published: November 2020

Background
Socioeconomic inequality in maternity care is well-evident in many developing countries including Bangladesh, but there is a paucity of research to examine the determinants of inequality and the changes in the factors of inequality over time. This study examines the factors accounting for the levels of and changes in wealth-related inequality in three outcomes of delivery care service: health facility delivery, skilled birth attendance, and C-section delivery in Bangladesh.

Methods
This study uses from the Bangladesh Demographic and Health Survey of 2011 and 2014. We apply logistic regression models to examine the association between household wealth status and delivery care measures, controlling for a wide range of sociodemographic variables. The Erreygers normalised concentration index is used to measure the level of inequalities and decomposition method is applied to disentangle the determinants contributing to the levels of and changes in the observed inequalities.

Results
We find a substantial inequality in delivery care service utilisation favouring woman from wealthier households. The extent of inequality increased in health facility delivery and C-section delivery in 2014 while increase in skilled birth attendance was not statistically significant. Wealth and education were the main factors explaining both the extent of and the increase in the degree of inequality between 2011 and 2014. Four or more antenatal care (ANC4+) visits accounted for about 8% to 14% of the observed inequality, but the contribution of ANC4+ visits declined in 2014.

Conclusion
This study reveals no progress in equity gain in the use of delivery care services in this decade compared to a declining trend in inequity in the last decade in Bangladesh. Policies need to focus on improving the provision of delivery care services among women from poorer socioeconomic groups. In addition, policy initiatives for promoting the completion of quality education are important to address the stalemate of equity gain in delivery care services in Bangladesh.
Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso
Authors: Kaboré Berenger , Post Annelies , Berendsen Mike L. T. , Diallo Salou , Lompo Palpouguini , Derra Karim , Rouamba Eli , Jacobs Jan , Tinto Halidou , de Mast Quirijn , van der Ven Andre J. 
Published: November 2020

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology analysers provide parameters for a more comprehensive analysis of RBC hemostasis. Complete blood counts were analysed in subjects from all age groups (n = 1118) living in a malaria hyperendemic area and cytokines and iron biomarkers were also measured. Subjects were divided into age groups (<2 years, 2–4, 5–14 and ≥15 years old) and clinical categories (smear-negative healthy subjects, asymptomatic malaria and clinical malaria). We found that hemoglobin levels were similar in smear-negative healthy children and asymptomatic malaria children but significantly lower in clinical malaria with a maximum difference of 2.2 g/dl in children <2 years decreasing to 0.1 g/dl in those aged ≥15 years. Delta-He, presenting different hemoglobinization of reticulocytes and RBC, levels were lower in asymptomatic and clinial malaria, indicating a recent effect of malaria on erythropoiesis. Reticulocyte counts and reticulocyte production index (RPI), indicating the erythropoietic capacity of the bone marrow, were higher in young children with malaria compared to smear-negative subjects. A negative correlation between reticulocyte counts and Hb levels was found in asymptomatic malaria (ρ = -0.32, p<0.001) unlike in clinical malaria (ρ = -0.008, p = 0.92). Free-Hb levels, indicating hemolysis, were only higher in clinical malaria. Phagocytozing monocytes, indicating erythophagocytosis, were highest in clinical malaria, followed by asymptomatic malaria and smear-negative subjects. Circulating cytokines and iron biomarkers (hepcidin, ferritin) showed similar patterns. Pro/anti-inflammatory (IL-6/IL-10) ratio was higher in clinical than asymptomatic malaria. Cytokine production capacity of ex-vivo whole blood stimulation with LPS was lower in children with asymptomatic malaria compared to smear-negative healthy children. Bone marrow response can compensate the increased red blood cell loss in asymptomatic malaria, unlike in clinical malaria, possibly because of limited level and length of inflammation.
Trial registration: Prospective diagnostic study: ClinicalTrials.gov identifier: NCT02669823.
Explorative cross-sectional field study: ClinicalTrials.gov identifier: NCT03176719.
Postoperative clinical outcomes and inflammatory markers after inguinal hernia repair using local, spinal, or general anesthesia: A randomized controlled trial
Authors: Wongyingsinn Mingkwan , Kohmongkoludom Pasawang , Trakarnsanga Atthaphorn , Horthongkham Navin 
Published: November 2020

BackgroundNo consensus has yet been reached regarding the best anesthetic technique for inguinal hernia repair. This study aimed to compare postoperative clinical outcomes and inflammatory markers among patients who were anesthetized using local, spinal, or general anesthesia for inguinal hernia repair.MethodsThis randomized controlled trial included patients scheduled to undergo elective unilateral inguinal hernioplasty at Siriraj Hospital during November 2014 to September 2015 study period. Patients were randomly assigned to the local (LA), spinal (SA), or general (GA) anesthesia groups. Primary outcomes were postoperative pain at rest and on mobilization at 8 and 24 hours after surgery.ResultsFifty-four patients were included, with 18 patients randomly assigned to each group. Patient demographic and clinical characteristics were similar among groups. There were no significant differences among groups for postoperative pain at rest or on mobilization at 8 and 24 hours after surgery. No significant differences were observed for interleukin-1β, interleukin-6, and interleukin-10 at any time points in any groups. Patients with local anesthesia was associated with less time spent in anesthesia (p= 0.010) and surgery (p= 0.009), lower intraoperative cost (p= 0.003) and total cost in hospital (p= 0.036); however, patient satisfaction in the local anesthesia group (94/100) was statistically significantly lower than the spinal and general anesthesia groups (100/100) (p= 0.010).ConclusionsNo statistically significant difference was observed among groups for postoperative pain scores, duration of hospital stays, complications, or change in inflammatory markers. However, time spent in anesthesia and surgery, the intraoperative cost and total cost for hernia repair, and patient satisfaction were significantly lower in the local anesthesia group than in the other two groups.
Publication rates of research projects of an internal funding program of a university medical center in Germany: A retrospective study (2004–2013)
Authors: Deutsch Susanne , Reuter Silke , Rose Astrid , Tolba René 
Published: November 2020

Objectives
Non-publication and publication bias are topics of considerable importance to the scientific community. These issues may limit progress toward the 3R principle for animal research, promote waste of public resources, and generate biased interpretations of clinical outcomes. To investigate current publishing practices and to gain some understanding of the extent to which research results are reported, we examined publication rates of research projects that were approved within an internal funding program of the Faculty of Medicine at a university medical center in Germany, which is exemplary for comparable research funding programs for the promotion of young researchers in Germany and Europe.

Methods
We analyzed the complete set (n = 363) of research projects that were supported by an internal funding program between 2004 and 2013. We divided the projects into four different proposal types that included those that required an ethics vote, those that included an animal proposal, those that included both requirements, and those that included neither requirement.

Results
We found that 65% of the internally funded research projects resulted in at least one peer-reviewed publication; this increased to 73% if other research contributions were considered, including abstracts, book and congress contributions, scientific posters, and presentations. There were no significant differences with respect to publication rates based on (a) the clinic/institute of the applicant, (b) project duration, (c) scope of funding or (d) proposal type.

Conclusion
To the best of our knowledge, this is the first study to explore publication rates associated with early-career medical research funding. As >70% of the projects ultimately generated some form of publication, the program was overall effective toward this goal; however, non-publication of research results is still prevalent. Further research will explore the reasons underlying non-publication. We hope to use these findings to develop strategies that encourage publication of research results.
Influence of Pre-Processing Strategies on the Performance of ML Classifiers Exploiting TF-IDF and BOW Features
Authors: Pimpalkar Amit Purushottam , Retna Raj R. Jeberson 
Published: November 2020

Data analytics and its associated applications have recently become impor-tant fields of study. The subject of concern for researchers now-a-days is a massive amount of data produced every minute and second as people con-stantly sharing thoughts, opinions about things that are associated with them. Social media info, however, is still unstructured, disseminated and hard to handle and need to be developed a strong foundation so that they can be utilized as valuable information on a particular topic. Processing such unstructured data in this area in terms of noise, co-relevance, emoticons, folksonomies and slangs is really quite challenging and therefore requires proper data pre-processing before getting the right sentiments. The dataset is extracted from Kaggle and Twitter, pre-processing performed using NLTK and Scikit-learn and features selection and extraction is done for Bag of Words (BOW), Term Frequency (TF) and Inverse Document Frequency (IDF) scheme.
For polarity identification, we evaluated five different Machine Learning (ML) algorithms viz Multinomial Naive Bayes (MNB), Logistic Regression (LR), Decision Trees (DT), XGBoost (XGB) and Support Vector Machines (SVM). We have performed a comparative analysis of the success for these algorithms in order to decide which algorithm works best for the given data-set in terms of recall, accuracy, F1-score and precision. We assess the effects of various pre-processing techniques on two datasets; one with domain and other not. It is demonstrated that SVM classifier outperformed the other classifiers with superior evaluations of 73.12% and 94.91% for accuracy and precision respectively. It is also highlighted in this research that the selection and representation of features along with various pre-processing techniques have a positive impact on the performance of the classification. The ultimate outcome indicates an improvement in sentiment classification and we noted that pre-processing approaches obviously suggest an improvement in the efficiency of the classifiers.
Strategic formulation of industrial maintenance based on equipment reliability in a sugar and ethanol production plant
Authors: Silva Elias Tadeu da , Achcar Jorge alberto , Piratelli Claudio Luis 
Published: November 2020

Maintenance and management have substantial importance in the search of the company’s competitive advantages. In this direction, a reliability analysis of equipments is very important for the definition of the most suitable maintenance strategy. The main goal of this paper is to assess the reliability-centered maintenance of the industrial reliability curve of a sugar cane department of an industry located in São Paulo State, Brazil. The proposed research method was based on the application of existing statistical modeling for the times between failures (TBF) of all reported equipment failures or the interruption times in the production line. These times were modeled by standard lifetime probability distributions as log-normal and Weibull distributions. The results showed that the company's strategy for preventive maintenance during the off-season is not adequate and the statistical analysis also identified important factors that affect the company's maintenance strategy. These results could be of great interest for the company and for engineering applications in general.
Mixed-integer nonlinear optimization for district heating network expansion
Authors: Roland Marius , Schmidt Martin 
Published: November 2020

Abstract
We present a mixed-integer nonlinear optimization model for computing the optimal expansion of an existing tree-shaped district heating network given a number of potential new consumers. To this end, we state a stationary and nonlinear model of all hydraulic and thermal effects in the pipeline network as well as nonlinear models for consumers and the network’s depot. For the former, we consider the Euler momentum and the thermal energy equation. The thermal aspects are especially challenging. Here, we develop a novel polynomial approximation that we use in the optimization model. The expansion decisions are modeled by binary variables for which we derive additional valid inequalities that greatly help to solve the highly challenging problem. Finally, we present a case study in which we identify three major aspects that strongly influence investment decisions: the estimated average power demand of potentially new consumers, the distance between the existing network and the new consumers, and thermal losses in the network.
Nonlinear model reduction of dynamical power grid models using quadratization and balanced truncation
Authors: Ritschel Tobias K. S. , Weiß Frances , Baumann Manuel , Grundel Sara 
Published: November 2020

Abstract
In this work, we present a nonlinear model reduction approach for reducing two commonly used nonlinear dynamical models of power grids: the effective network (EN) model and the synchronous motor (SM) model. Such models are essential in real-time security assessments of power grids. However, as power grids are often large-scale, it is necessary to reduce the models in order to utilize them in real-time. We reformulate the nonlinear power grid models as quadratic systems and reduce them using balanced truncation based on approximations of the reachability and observability Gramians. Finally, we present examples involving numerical simulation of reduced EN and SM models of the IEEE 57 bus and IEEE 118 bus systems.
Transient stability analysis of power grids with admissible and maximal robust positively invariant sets
Authors: Aschenbruck Tim , Esterhuizen Willem , Streif Stefan 
Published: November 2020

Abstract
The energy transition is causing many stability-related challenges for power systems. Transient stability refers to the ability of a power grid’s bus angles to retain synchronism after the occurrence of a major fault. In this paper a set-based approach is presented to assess the transient stability of power systems. The approach is based on the theory of barriers, to obtain an exact description of the boundaries of admissible sets and maximal robust positively invariant sets, respectively. We decompose a power system into generator and load components, replace couplings with bounded disturbances and obtain the sets for each component separately. From this we deduce transient stability properties for the entire system. We demonstrate the results of our approach through an example of one machine connected to one load and a multi-machine system.
Optimization-based primary and secondary control of microgrids
Authors: Nurkanović Armin , Mešanović Amer , Sperl Mario , Albrecht Sebastian , Münz Ulrich , Findeisen Rolf , Diehl Moritz 
Published: November 2020

Abstract
This article discusses how to use optimization-based methods to efficiently operate microgrids with a large share of renewables. We discuss how to apply a frequency-based method to tune the droop parameters in order to stabilize the grid and improve oscillation damping after disturbances. Moreover, we propose a centralized real-time feasible nonlinear model predictive control (NMPC) scheme to achieve efficient frequency and voltage control while considering economic dispatch results. Centralized NMPC for secondary control is a computationaly challenging task. We demonstrate how to reduce the computational burden using the Advanced Step Real-Time Iteration with nonuniform discretization grids. This reduces the computational burden up to 60 % compared to a standard uniform approach, while having only a minor performance loss. All methods are validated on the example of a 9-bus microgrid, which is modeled with a complex differential algebraic equation.
Clinical relevance of biological variation of cardiac troponins
Authors: Clerico Aldo , Padoan Andrea , Zaninotto Martina , Passino Claudio , Plebani Mario 
Published: November 2020

Abstract
The high-sensitivity immunoassays for cardiac troponin I (hs-cTnI) and cardiac troponin T (hs-cTnT) are recommended by all the most recent international guidelines as gold standard laboratory methods for the detection of myocardial injury and diagnosis of acute myocardial infarction (AMI). In this review article, the Authors aimed at discussing the relevant biochemical, physiological, and clinical issues related to biological variability of cTnI and cTnT. Cardiac troponins, measured with hs-cTn methods, show a better clinical profile than the other cardio-specific biomarkers (such as the natriuretic peptides, BNP and NT-proBNP). In particular, the hs-cTn methods are characterized by a low intra-individual index of variation (<0.6) and reduced analytical imprecision (about 5% CV) at the clinical cut-off value (i.e., the 99th percentile URL value). Moreover, recent studies have reported that differences between two hs-cTn measured values (RCV) >30% can be considered statistically significant. These favourable biological characteristics and analytical performance of hs-cTn methods significantly improved the accuracy in the diagnostic process of acute coronary syndromes (ACS) in patients admitted to emergence department. In addition, several studies have demonstrated the clinical usefulness of cardiovascular risk evaluation with hs-cTn methods in some groups of patients with clinical conditions at high cardiovascular risk (such as systemic hypertension, severe obesity, diabetes mellitus, renal insufficiency, and chronic obstructive pulmonary disease). However, screening programs in the general population with hs-cTn methods for cardiovascular risk stratification require further investigation to define the optimal target populations, timing of measurement, and preventive interventions.