bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of genetic effects and functional SNPs of bovine HTR1B gene on milk fatty acid traits
Authors: Cao Mingyue , Shi Lijun , Peng Peng , Han Bo , Liu Lin , Lv Xiaoqing , Ma Zhu , Zhang Shengli , Sun Dongxiao 
Published: December 2020

Abstract
Background: Our previous genome-wide association study (GWAS) on milk fatty acid traits in Chinese Holstein cows revealed, the SNP, BTB-01556197, was significantly associated with C10:0 at genome-wide level (P = 0.0239). It was located in the down-stream of 5-hydroxytryptamine receptor 1B (HTR1B) gene that has been shown to play an important role in the regulation of fatty acid oxidation. Hence, we considered it as a promising candidate gene for milk fatty acids in dairy cattle. In this study, we aimed to investigate whether the HTR1B gene had significant genetic effects on milk fatty acid traits.Results: We re-sequenced the entire coding region and 3,000 bp of 5' and 3' flanking regions of HTR1B gene. A total of 13 SNPs was identified, containing one in 5' flanking region, two in 5' untranslated region (UTR), two in exon 1, five in 3' UTR, and three in 3' flanking region. By performing genotype-phenotype association analysis with SAS9.2 software, we observed that 13 SNPs were significantly associated with medium-chain saturated fatty acids such as C6:0, C8:0 and C10:0 (P < 0.0001 ~ 0.042). With Haploview 4.1 software, linkage disequilibrium (LD) analysis was performed that two haplotype blocks formed by two and ten SNPs were observed. Haplotype-based association analysis indicated that both haplotype blocks were strongly associated with C6:0, C8:0 and C10:0 as well (P < 0.0001 ~ 0.0071). With regards to the missense mutation in exon 1 (g.17303383G>T) that reduced amino acid change from alanine to serine, we predicted that it altered the secondary structure of HTR1B protein with SOPMA. In addition, we predicted that three SNPs in promoter region, g.17307103A>T, g.17305206T>G and g.17303761C>T, altered the binding sites of transcription factors (TFs) HMX2, PAX2, FOXP1ES, MIZ1, CUX2, DREAM, and PPAR-RXR by Genomatix. Of them, luciferase assay experiment further confirmed that the allele T of g.17307103A>T significantly increased the transcriptional activity of HTR1B gene than allele A (P = 0.0007).Conclusions: In conclusion, our findings provided first evidence that the HTR1B gene had significant genetic effects on milk fatty acids in dairy cattle.
On Big Data Forensic - A Case For Forensic Cloud Environment
Authors: Tabona Oteng , Maupong Thabiso , Ramokapane Kopo , Semong Thabo , Mphago Banyatsang 
Published: December 2020

Abstract
Background The high rise in electronic devices in modern-day society has resulted in crimes in cyber-related crimes as criminals resort to hacking, illegal use of these devices. This is primarily due to perceived high rewards and low chances of being apprehended. The rise in cyber crimes poses a significant challenge to forensic investigators as now they have to process huge volumes of data from a variety of sources within a limited time. This results in investigators taking longer to process cases and in some instances missing links as they deal with data from a variety of sources. Findings In this paper, we provide a definition of big data forensics, and then we discuss the challenges associated with digital forensics investigations when dealing with big data. We provide details on how volume, variety, and velocity all pose a huge challenge in digital forensics investigations. We then discuss how a novel solution called Forensic Cloud Environment (FCE) leverages the power of Hadoop, HBase, and MapReduce to provide a solution for big data forensic challenges. Conclusion In conclusion, the fact that FCE provides an environment to store huge volumes of data from a variety of sources allows for an improved processing time of data. Hence, providing an environment for big data forensics for the future.
Application of Nitrogen Heterocyclic Carbenes in Organocatalysis
Authors: Ojha Minita , Bansal R. K. 
Published: December 2020

Background:
During the last two decades, horizon of research in the field of Nitrogen
Heterocyclic Carbenes (NHC) has widened remarkably. NHCs have emerged as ubiquitous species
having applications in a broad range of fields, including organocatalysis and organometallic chemistry.
The NHC-induced non-asymmetric catalysis has turned out to be a fruitful area of research in
recent years.

Methods:
By manipulating structural features and selecting appropriate substituent groups, it has
been possible to control the kinetic and thermodynamic stability of a wide range of NHCs, which
can be tolerant to a variety of functional groups and can be used under mild conditions. NHCs are
produced by different methods, such as deprotonation of N-alkylhetrocyclic salt, transmetallation,
decarboxylation and electrochemical reduction.

Results:
The NHCs have been used successfully as catalysts for a wide range of reactions making
a large number of building blocks and other useful compounds accessible. Some of these reactions
are: benzoin condensation, Stetter reaction, Michael reaction, esterification, activation of esters,
activation of isocyanides, polymerization, different cycloaddition reactions, isomerization, etc. The
present review includes all these examples published during the last 10 years, i.e., from 2010 till
date.

Conclusion:
The NHCs have emerged as versatile and powerful organocatalysts in synthetic organic
chemistry. They provide the synthetic strategy which does not burden the environment with
metal pollutants and thus fits in the Green Chemistry.
A Review and Catalog of Security Metric during the Secure Software Development Life Cycle
Authors: Sampada G.C. , Sake Tende Ivo , Amrita  
Published: December 2020

Background:
With the advancement in the field of software development, software poses
threats and risks to customers’ data and privacy. Most of these threats are persistent because security
is mostly considered as a feature or a non-functional requirement, not taken into account during the
Software Development Life Cycle (SDLC).

Introduction:
In order to evaluate the security performance of a software system, it is necessary to
integrate the security metrics during the SDLC. The appropriate security metrics adopted for each
phase of SDLC aids in defining the security goals and objectives of the software as well as quantify
the security in the software.

Methods:
This paper presents a review and catalog of security metrics that can be adopted during
the distinguishable phases of SDLC, security metrics for vulnerability and risk assessment reported
in the literature for secure development of software. The practices of these metrics enable software
security experts to improve the security characteristics of the software being developed. The critical
analysis of security metrics of each phase and their comparison are also discussed.

Results:
Security metrics obtained during the development processes help to improve the confidentiality,
integrity, and availability of software. Hence, it is imperative to consider security during the
development of the software, which can be done with the use of software security metrics.

Conclusion:
This paper reviews the various security metrics that are meditated in the copious phases
during the progression of the SDLC in order to provide researchers and practitioners with substantial
knowledge for adaptation and further security assessment.
Les manuels utilisés dans l’enseignement du français en Russie au XVIIIe siècle: influences occidentales et leur réсeption en Russie
Authors: Vlassov Serguey 
Published: December 2020

«Учебники, используемые в преподавании французского языка в России в XVIII веке : западные влияния и их рецепция в России» Статья посвящена анализу грамматик, «школьных» и «домашних» «разговоров», букварей, использовавшихся в России сначала в частном преподавании французского языка детям Петра Великого (цесаревичу Алексею и будущей императрице Елизавете Петровне), а также в частных пансионах, а затем в государственных учебных заведениях Санкт-Петербурга (в академической гимназии, в Сухопутном шляхетном кадетском корпусе и в Морском кадетском корпусе) и Москвы (в гимназиях и, позднее, в Благородном пансионе при Московском университете). Как показало проведенное исследование, преподавание французского языка в России было сначала ориентировано на немецкие образцы, но затем французские модели учебников постепенно вытеснили своих немецких конкурентов благодаря адаптации к российским условиям прежде всего грамматики Ресто - в учебниках П. де Лаваля, Л. Бужо, Ж.-Р. Готье и других французских учителей, эмигрировавших в Россию при Елизавете Петровне и Екатерине II. Тем не менее влияние французской философской грамматики проявляется в преподавании французского языка в России лишь с 90-х годов XVIII в. – в грамматиках И. Соца (1790) и И. Фабиана (1799), так как ранее заимствования в грамматике Ресто из философской грамматики устранялись из переделок его грамматики в России. Кроме печатных источников, в статье рассматриваются некоторые неизданные материалы, хранящиеся в Архиве Академии наук, в Военно-морском архиве и в рукописных отделах Библиотеки Академии наук и Российской национальной библиотеки.
Conceptual History, Cultural History, Social History
Authors: Zhivov (†) Viktor 
Published: December 2020

V. M. Zhivov’s introduction to Studies in Historical Semantics of the Russian Language in the Early Modern Period (2009), translated here for the first time, offers a critical survey of the historiography on Begriffsgeschichte, the German school of conceptual history associated with the work of Reinhart Koselleck, as well as of its application to the study of Russian culture. By situating Begriffsgeschichte in the context of late-nineteenth and early twentieth-century European philosophy, particularly hermeneutics and phenomenology, the author points out the important, and as yet unacknowledged, role that Russian linguists have played in the development of a native school of conceptual history. In the process of outlining this alternative history of the discipline, Zhivov provides some specific examples of the way in which the study of “historical semantics” can be used to analyze the development of Russian modernity.
A Self-Assessment Web-Based App to Assess Trends of the COVID-19 Pandemic in France: Observational Study (Preprint)
Authors: Denis Fabrice , Fontanet Arnaud , Le Douarin Yann-Mael , Le Goff Florian , Jeanneau Stephan , Lescure François-Xavier 
Published: December 2020

BACKGROUND

We developed a self-assessment and participatory web-based triage app to assess the trends of the COVID-19 pandemic in France in March 2020.

OBJECTIVE

We compared daily large-scale RT–PCR test results to monitor recent reports of anosmia through a web-based app to assess the dynamics of emergency department visits, hospitalizations, and intensive care unit (ICU) admissions among individuals with COVID-19 in France.

METHODS

Between March 21 and November 18, 2020, users of the maladiecoronavirus.fr self-triage app were asked questions about COVID-19 symptoms. Data on daily hospitalizations, large-scale positive results on RT–PCR tests, emergency department visits, and ICU admission of individuals with COVID-19 were compared to data on daily reports of anosmia on the app.

RESULTS

As of November 18, 2020, recent anosmia was reported 575,214 times from among approximately 13,000,000 responses. Daily anosmia reports during peak engagement with the app on September 16, 2020, were spatially correlated with the peak in daily COVID-19–related hospitalizations in November 2020 (Spearman rank correlation coefficient [ρ]=0.77; <i>P</i><.001). This peak in daily anosmia reports was observed primarily among young adults (age range 18-40 years), being observed 49 days before the peak of hospitalizations that corresponded to the first wave of infections among the young population, followed by a peak in hospitalizations among older individuals (aged ≥50 years) in November 2020. The reduction in the daily reports of anosmia associated with the peaks in the number of cases preceded the reduction in daily hospitalizations by 10 and 9 days during the first and the second waves of infection, respectively, although the reduction in the positivity rates on RT–PCR tests preceded the reduction in daily hospitalizations by only 2 days during the second wave of infections.

CONCLUSIONS

Data on daily reports of anosmia collected through a nationwide, web-based self-assessment app can be a relevant tool to anticipate surges in outbreaks, hospitalizations, and ICU admission during the COVID-19 pandemic.

CLINICALTRIAL

ClinicalTrials.gov NCT04331171; https://clinicaltrials.gov/ct2/show/NCT04331171
Una retórica revolucionaria: el caso de las poéticas centroamericanas
Authors: Romero Figueroa Edgar 
Published: December 2020

La lectura de cuatro poetas centroamericanos: Ernesto Cardenal, Roberto Sosa, Otto René Castillo y Roque Dalton permite esbozar la caracterización de una cierta poesía revolucionaria de la segunda mitad del siglo XX, desde una perspectiva retórico-discursiva. Para ello, se cuestiona la función que algunos dispositivos retóricos específicos (figuras como la metáfora o estrategias complejas, y por ende difícilmente clasificables, como el motivo o topos) cumplen en los proyectos poético-revolucionarios.Abstract: Through the work of four Central American poets: Ernesto Cardenal, Roberto Sosa, Otto René Castillo, and Roque Dalton, we describe the features of certain revolutionary poetry of the second half of the 20th century, from a rhetorical and discourse theory perspective. For this, we question the function of some specific rhetorical devices (figures like the metaphor or complex strategies, therefore difficult to classify, as the motif or topos) in revolutionary poetic projects.Key words: Central American poets, Central America, revolution, rhetoric, second half of 20th century.Résumé : La lecture de quatre poètes centre-américains, Ernesto Cardenal, Roberto Sosa, Otto René Castillo et Roque Dalton permet d’esquisser la caractérisation d’une certaine poésie révolutionnaire de la deuxième moitié du XXe siècle depuis une perspective réthorico-discursive. Pour ce faire, nous interrogeons la fonction de certains dispositifs rhétoriques précis (figures de style telles que la métaphore mais aussi stratégies complexes et donc difficilement classables, comme le motif et le topos) dans les projets poético-révolutionnaires.Mots-clés : poètes centre-américains, Amérique centrale, révolution, rhétorique, deuxième moitié du XXe siècle.
Reseña del libro Gobernanza ambiental. Conservación de áreas naturales protegidas urbanas y servicios ambientales. El caso de los sistemas de Guadalajara y Monterrey, México
Authors: Jiménez-Martínez Nancy Merary 
Published: December 2020

El tema que aborda este libro es el establecimiento, operación, alcances y dificultades de las áreas de protección ambiental que, para evitar la degradación, contribuir a la conservación de los ecosistemas e imponer límites al crecimiento urbano, se instalan en las áreas urbanas. La relevancia del tema radica en el carácter que estos espacios revisten en dichos entornos, ya que constituyen las únicas zonas naturales disponibles para proveer servicios ambientales vitales para la sociedad (como la captación de agua, la regulación climática, la prevención de inundaciones, entre otros) y, al mismo tiempo, representan un territorio amenazado permanentemente por la expansión urbana. En este escenario, la autora centra su análisis en las problemáticas que enfrentan tanto las autoridades como la sociedad en general para lograr la gestión de las áreas naturales protegidas.
HETEROSIS DAN HERITABILITAS PADA PROGENI F1 HASIL PERSILANGAN KEKERABATAN JAUH TANAMAN KARET
Authors: Sayurandi Sayurandi , Daslin Aidi 
Published: December 2020

Perbaikan potensi genetik merupakan faktor yang penting dalam upaya meningkatkan produktivitas karet. Kemajuan pemuliaan karet sangat tergantung kepada potensi dan ketersediaan sumber keragaman genetik, yang diperoleh melalui kegiatan persilangan antara tetua yang memiliki hubungan kekerabatan jauh. Seleksi progeni pada populasi F1 diharapkan dapat menghasilkan keturunan yang lebih baik dari kedua tetuanya, yang besarnya dapat diukur dari nilai heterosis, heterobeltiosis, derajat dominansi gen yang diukur dari rasio nilai potensi, dan heritabilitas. Untuk mempelajari pengaruh parameter tersebut dilakukan suatu analisis dengan menggunakan 40 progeni F1 umur enam tahun hasil persilangan PB 260 dan PN 7111 yang memiliki hubungan kekerabatan genetik jauh. Hasil analisis menunjukkan keragaman yang cukup signifikan pada tujuh peubah yang diamati, dengan koefisien keragaman produksi g/p/s (62,39%), lilit batang (22,02%), jumlah ring pembuluh lateks (28,17%), diameter pembuluh lateks (17,72%), indeks penyumbatan (41,01%), kadar sukrosa (30,13%), dan kadar fosfat anorganik (69,78%). Berdasarkan nilai heterosis pada karakter lilit batang, progeni nomor 1087, 1184, dan 1086 memiliki nilai heterosis bernilai positif, sedangkan progeni yang lain bernilai negatif. Nilai heterobeltiosis untuk karakter lilit batang dari 40 progeni F1 bernilai negatif. Demikian juga untuk karakter hasil lateks, 40 progeni F1 tersebut memiliki nilai heterosis dan heterobeltiosis bernilai negatif. Berdasarkan derajat dominansi gen yang diukur dengan rasio nilai potensi pada karakter ukuran lilit batang, progeni nomor 1089, 1184, dan 1086 menunjukkan aksi gen dominan positif tidak sempurna, sedangkan untuk karakter hasil lateks, keempat puluh progeni F1 menunjukkan aksi gen dominan negatif tidak sempurna. Nilai heritabilitas karakter hasil lateks, jumlah ring pembuluh lateks, diameter ring pembuluh lateks, kadar sukrosa, dan kadar fospat anorganik tergolong tinggi dengan nilai h2 antara 0,52–0,85, sedangkan nilai heritabilitas karakter lilit batang dan indeks penyumbatan tergolong sedang, dengan nilai h2 masing- masing yaitu 0,39 dan 0,47. How to Cite : Sayurandi, & Daslin, A. (2011). Heterosis dan heritabilitas pada progeni F1 hasil persilangan kekerabatan jauh tanaman karet. Jurnal Penelitian Karet, 29(1), 1-15. Retrieved from http://ejournal.puslitkaret.co.id/index.php/jpk/article/view/105
DINAMIKA GUGUR DAUN DAN PRODUKSI BERBAGAI KLON KARET KAITANNYA DENGAN KANDUNGAN AIR TANAH
Authors: Ardika Risal , Cahyo Andi Nur , Wijaya Thomas 
Published: December 2020

Curah hujan berpengaruh terhadap ketersediaan air tanah. Pada waktu musim kemarau curah hujan menurun sehingga air menjadi faktor pembatas bagi pertumbuhan tanaman karet. Dengan adanya keterbatasan air pada waktu musim kemarau tersebut tanaman karet melakukan adaptasi untuk mengurangi transpirasi dengan cara menggugurkan daunnya. Beberapa jenis klon karet memiliki tipe yang berbeda-beda dalam menggugurkan daunnya karena adanya defisit air dalam tanah, yaitu klon karet yang serentak maupun yang bertahap dalam menggugurkan daunnya pada waktu musim kemarau. Oleh karena itu perlu diadakan suatu penelitian tentang dinamika gugur daun berbagai klon karet kaitannya dengan kandungan air tanah dan produksi pada daerah selatan khatulistiwa. Bahan yang dipakai dalam penelitian ini adalah tanaman karet klon BPM 24, GT 1, RRIC 100 dan PB 260 tahun tanam 2000. Alat yang digunakan dalam penelitian ini adalah alat pengukur kadar air tanah Troxler Sentry 200 AP, oven, dan pipa pralon. Penelitian dilaksanakan di Kebun Percobaan Balai Penelitian Sembawa. Penelitian dilaksanakan dengan cara menanam pipa pralon ke dalam tanah sepanjang 1,5 m di dalam barisan tanaman dan di dalam gawangan tanaman karet. Parameter yang diamati meliputi kadar air tanah, produksi, waktu terjadinya gugur daun, luas daun spesifik, dan indeks luas daun (ILD). Data hasil penelitian menunjukkan bahwa klon PB 260 lebih dahulu menggugurkan daunnya dibandingkan dengan klon BPM 24, RRIC 100, dan GT 1. Produksi karet mulai menurun saat ILD mencapai angka sekitar 1 atau menurun sebesar 40%. Konsumsi air klon GT 1 relatif lebih tinggi dibandingkan dengan klon BPM 24, RRIC 100 dan PB 260. Diterima : 25 Januari 2011; Disetujui : 1 Juni 2011How to Cite : Ardika, R., Cahyo, A.N., & Wijaya, T. (2011). Dinamika gugur daun dan produksi berbagai klon karet kaitannya dengan kandungan air tanah. Jurnal Penelitian Karet, 29(2), 102-109. Retrieved from http://ejournal.puslitkaret.co.id/index.php/jpk/article/view/242
PERMINTAAN EKSPOR SARUNG TANGAN LATEKS MALAYSIA
Authors: Syarifa Lina Fatayati 
Published: December 2020

Malaysia merupakan penyalur terkemuka untuk produk sarung tangan medis/bedah, dengan menguasai 45% dari permintaan dunia. Namun, permintaan ekspor untuk sarung tangan tersebut berfluktuasi dari waktu ke waktu. Hal ini antara lain disebabkan oleh perubahan faktor-faktor harga ekspor, pendapatan luar negeri, dan harga karet sintetis dunia. Untuk meningkatkan ekspornya, beberapa kebijakan telah dikeluarkan melalui Industrial Master Plan. Tujuan penelitian ini adalah untuk mengestimasi elastisitas permintaan ekspor sarung tangan terhadap perubahan faktor-faktor yang mempengaruhi permintaan ekspornya secara signifikan. Data triwulan digunakan untuk mengestimasi fungsi permintaan ekspor dengan model ECM. Hasil estimasi menunjukkan bahwa elastisitas harga ekspor sarung tangan signifikan nilainya sebesar -1,14, menunjukkan bahwa nilainya adalah elastis. Dengan demikian, perubahan harga ekspor sarung tangan akan memberikan efek sangat penting bagi jumlah ekspor yang diminta. Berdasarkan elastisitas pendapatan luar negeri terhadap sarung tangan adalah 0,5 dan tidak signifikan secara statistik, menunjukkan bahwa pendapatan luar negeri tidak menjadi penentu penting dari permintaan ekspor sarung tangan. Kemudian, elastisitas harga substitusi nilainya sebesar 0,05, menunjukkan bahwa nilainya inelastis terhadap karet sintetis. Diterima : 2 September 2011; Disetujui : 26 November 2011How to Cite : Syarifa, L. F. (2011). Permintaan ekspor sarung tangan lateks malaysia. Jurnal Penelitian Karet, 29(2), 151-158. Retrieved from http://ejournal.puslitkaret.co.id/index.php/jpk/article/view/247
SIMULASI PENETAPAN KARAKTERISTIK PENGERINGAN SEMPROT LATEKS BERDASARKAN TEKNIK KOMPUTASI DINAMIKA FLUIDA
Authors: Vachlepi Afrizal , Suwardin Didin , Abidin A. Zainal 
Published: December 2020

Tujuan dari penelitian ini adalah untuk mempelajari karakteristik proses pengeringan lateks karet alam dengan alat pengering semprot menggunakan pendekatan teknik komputasi dinamika fluida (computational fluid dynamic/CFD). Kegiatan penelitian ini meliputi penentuan model CFD untuk menggambarkan sistem pengeringan semprot, penentuan kondisi batas simulasi, penentuan parameter operasi, dan simulasi pengeringan. Variasi perlakuan berupa kadar air lateks terdiri atas 65%, 70%, 75%, dan 80%. Sedangkan suhu udara pengering terdiri atas 140°C, 150°C, 160°C, 170°C, dan 180°C. Dari penelitian yang sudah dilakukan dapat disimpulkan bahwa kadar air lateks dan suhu udara pengering berpengaruh terhadap proses pengeringan kaitannya dengan kecepatan udara-partikel, waktu pengeringan, diameter partikel, kadar air produk, dan perubahan suhu udara-partikel. Simulasi CFD memprediksi diameter partikel produk akhir sekitar 130-135 micrometer dengan kadar air sekitar 0,32-0,58%. Suhu produk akhir yang keluar dari ruang pengering sekitar 37-54 °C. Diterima : 1 November 2012; Disetujui : 7 April 2013 How to Cite : Vachlepi, A., Suwardin, D., & Abidin, A. Z. (2013). Simulasi penetapan karakteristik pengeringan semprot lateks berdasarkan teknik komputasi dinamika fluida. Jurnal Penelitian Karet, 31(1), 30-44. Retrieved from http://ejournal.puslitkaret.co.id/index.php/jpk/article/view/131