bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparedness and Approaches of Healthcare Providers to Tackle the Transmission of Covid-19 among North Shewa Zone Hospitals, Amhara, Ethiopia, 2020.
Authors: Mulu Getaneh Baye , Kebede worku Misganaw , worku Solomon Adanew , Mittiku Yohannes Moges , Jemere Birhanu Ayelign 
Published: June 2020

Abstract
Background

Coronavirus disease 2019 (COVID-19 is an emerging respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China. The disease is highly infectious, and its main clinical symptoms include fever, dry cough, fatigue, myalgia, and dyspnea. Health care providers are in front in fighting the coronavirus spread by making themselves the risk of contracting the disease. This study aimed to assess the preparedness and approaches of healthcare providers to tackle the transmission of COVID-19 among North Shewa Zone Hospitals.
Methods

Facility-based cross-sectional study was conducted from April to May 2020 among 422 healthcare providers in the North Shewa Zone, Amhara, Ethiopia using a self-administered questionnaire. Study subjects were selected through systematic random sampling based on their proportional distribution of sample size to each hospital. A structured questionnaire will be used to collect data. The data were coded and entered into the Epi data 4.2.1 version and the analysis was carried out in statistical package for social science 25 versions.
Results

404 participants involved in the study gives a response rate of 95.7%. The self-satisfaction of healthcare providers revealed 301 (74.5%) of study participants feel unsafe in their workplace. Two-third, 260 (64.4%) of them responded that they feel anxious while working with febrile patients. Nearly one -third (31%), 27.4%, 15.9%, 14.5%, 14.2% of HCP had access to gloves, facemask, goggle, shoe, and apron respectively in hospitals.
Conclusion

Protecting healthcare workers is a public health priority. Access to essential personal protective equipment during the COVID-19 pandemic was limited. The poor perception of healthcare professionals about not having enough support from medical institutions and public health authorities raises the need to urgently implement strategies to protect healthcare workers in the time of the COVID-19 pandemic.
SARS-CoV-2: High-Resolution Microscopy Study in Human Nasopharyngeal Samples.
Authors: Mondeja Brian , Valdes Odalys , Resik Sonia , Vizcaino Ananayla , Acosta Emilio , Montalván Adelmo , Paez Amira , Mune Mayra , Rodríguez Roberto , Valdés Juan , Gonzalez Guelsys , Sanchez Daisy , Falcón Viviana , González Yorexis , Kourí Vivian , Group The IPK Virology Research , Díaz Angelina , Guzmán Maria 
Published: June 2020

Abstract
BackgroundThe novel coronavirus SARS-CoV-2 is the etiological agent of COVID-19. This virus has become one of the most dangerous in recent times with a very high rate of transmission. At present, several publications show the typical crown-shape of the novel coronavirus grown in cell cultures. However, an integral ultramicroscopy study done directly from clinical specimens has not been published. Methods Nasopharyngeal swabs were collected from two Cuban individuals, one asymptomatic and RT-PCR negative (negative control) and the other from a COVID-19 symptomatic and RT-PCR positive for SARS CoV-2. Samples were treated with an aldehyde solution and processed by Scanning Electron Microscopy, Confocal Microscopy and, Atomic Force Microscopy. Improvement and segmentation of coronavirus images were performed by mathematic algorithms. Results The images of the negative control sample showed the characteristic healthy microvilli morphology at the apical region of the nasal epithelial cells. As expected, they do not display virus-like structures. The images of the positive sample showed characteristic coronavirus-like particles and evident destruction of microvilli. In some regions, virions gemmating through the cell membrane were observed. Microvilli destruction could explain the anosmia reported by some patients. Virus-particles emerging from the cell-surface with a variable size ranging from 80 to 400 nm were observed by scanning electron microscopy (SEM). A confocal study showed viral antigen recognition in the apical cells zone. Conclusions The integral microscopy study showed that SARS-CoV-2 has a similar image to SARS-CoV. The application of several high-resolution microscopy techniques to clinical samples can help to answer important questions its replicative cycle and immunopathogenic mechanism of this novel coronavirus, relevant for the development of new treatments against this disease.
Blood manganese and cognitive and motor skills at age 6-7 in Canadian cohort GESTE
Authors: Staedelin Luc , Nadia Abdelouahab , Desautels Anne-Sandrine , Gillet Virginie , Boivin Amélie , Wilkie Erin , Farmer Marie , Brennan Kasey J.M , Laue Hannah E. , Bocti Christian , Baccarelli Andrea A. , Takser Larissa 
Published: June 2020

Abstract
Background: Increasing evidence suggests that high exposure to manganese (Mn) may impair brain development. In Canada, Mn exposure comes from several environmental sources and the most common is drinking water. Our objective was to examine the relationship between blood Mn and psychomotor skills in school-aged children from the Eastern Townships, Qc, Canada. In addition, we examined the association of Mn with Attention-Deficit Hyperactivity Disorder (ADHD) diagnosis in our study group.Methods: Children were recruited at birth (through their mother) and followed prospectively. At 6-7 years of age, 210 children provided a blood sample for manganese testing and underwent a battery of neuropsychological tests. This battery assessed several major cognitive domains including general intelligence, attention and others via subtests from the Wechsler Intelligence Scale for Children – IV (WISC-IV), the Developmental NEuroPSYchological Assessment-II (NEPSYII) and the Test of Everyday Attention for Children (TEACH). Parents were asked if their child had ever received a physician diagnosis of ADHD. Blood was analysed by inductively coupled plasma mass spectrometry. Multivariate statistic modelling was used to control for potential confounding factors, including blood lead.Results: Median blood Mn was 9.9 µg/L (range 4.7 – 21.4 µg/L). The Design Copying – Fine motor score of the NEPSYII was positively associated with blood Mn (linear model β: 0.17 [95% Confidence Interval: 0.03 to 0.32]; adjusted model β: 0.16 [95% Confidence Interval 0.01 to 0.30]). Blood Mn was not associated with diagnosis of ADHD. Sex-stratified analyses indicated potential effect modification by child sex such that manganese had a beneficial association on the Score DT test (a measure of sustained attention), but only among boys (β: 0.29, [95% confidence interval: 0.098 to 0.49]) Conclusions: In agreement with studies from areas with similar environmental Mn levels, our study suggests that blood Mn level does not have wide-ranging associations with cognitive functions, psychomotor skills, or a diagnosis/suspicion of ADHD in school-aged children. To resolve the controversy about toxicity of environmental Mn on the developing brain, further studies should simultaneously focus on several biomarkers of Mn exposure, potential lifestyle protective factors, as well as brain imaging.
“Porcine Digestible Peptides (Pdp) in Weanling Diets Improves Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs”&nbsp;
Authors: González-Solé Francesc , Criado-Mesas Lourdes , Villodre Carmen , García Wellington C. , Farré Mercè , Borda Elisabet , Pérez-Cano Francisco J. , Folch Josep M. , Solà-Oriol David , Pérez José F. 
Published: June 2020

Abstract
Background: Porcine digestive peptides (PDP) have proven to be a valid substitute for other high-quality dietary protein sources for piglets, like spray-dried plasma (SDP), but knowledge about their influence on intestinal function is still scarce. This study was conducted to investigate the effects of PDP, SDP or a combination of both on growth performance and intestinal function of weaned pigs. Results: A total of 180 piglets (Trial 1) and 198 piglets (Trial 2) were used to evaluate the partial substitution of soybean ingredients with 2% SDP or 2% PDP (Trial 1), and with 3% SDP or the combination of 1% SDP and 2% PDP (SDP-PDP; Trial 2) during the pre-starter period (d0-14). A common commercial diet was offered up to day 35 in Trial 2. The effects on intestinal function were evaluated by quantifyingthe gene expression (56 genes in an Open Array Real-Time PCRPlatform) in jejunum and ileum samples obtained from piglets on d 14 after weaning (Trial 2).Piglets fed SDP, PDP and SDP-PDP had a higher body weight (BW), average daily gain (ADG) and feed efficiency (G:F) than the soybean controlon day 14 (P< 0.05), but no differences were observed among groups at the end of starter phase (Trial 2). Ten genes in jejunum and five in ileum samples were differentially expressed among treatments (P< 0.05). The highest expression was found in the SDP-PDP group. These genes are involved in the barrier function of intestinal cells,the immune response, mucosal nutrient transport, digestion and metabolization of oxidation products. Conclusion: The combination of SDP and PDP upregulated genes related to the intestinal functionwithout affecting growth performance. The underlying mechanisms that produced these effects are still unknown; however, protein hydrolysates might contain bioactive peptides that could be the cause.
Effects of Desflurane and Sevoflurane Anesthesia on Regulatory T Cells in Patients Undergoing Living Donor Kidney Transplantation: A Randomized Intervention Trial
Authors: Chutipongtanate Arpa , Prukviwat Sasichol , Pongsakul Nutkridta , Sris Supanart , Kamanee Nakarin , Arpornsujaritkun Nuttapon , Gesprasert Goragoch , Apiwattanakul Nopporn , Hongeng Suradej , Ittichaikulthol Wichai , Sumethkul Vasant , Chutipongtanate Somchai 
Published: June 2020

Abstract
Background: Volatile anesthetic agents used during surgery have immunomodulatory effects which could affect postoperative outcomes. Recognizing that regulatory T cells (Tregs) plays crucial roles in transplant tolerance and high peripheral blood Tregs associated with stable kidney graft function, knowing which volatile anesthetic agents can induce peripheral blood Tregs increment would have clinical implications. This study aimed to compare effects of desflurane and sevoflurane anesthesia on peripheral blood Tregs induction in patients undergoing living donor kidney transplantation.Methods: A prospective, randomized, double-blind trial in living donor kidney transplant recipients was conducted at a single center, tertiary-care, academic university hospital in Thailand during August 2015 – June 2017. Sixty-six patients were assessed for eligibility and 40 patients who fulfilled the study requirement were equally randomized and allocated to desflurane versus sevoflurane anesthesia during transplant surgery. The primary outcome included absolute changes of peripheral blood CD4+CD25+FoxP3+Tregs which measured by flow cytometry and expressed as the percentage of the total population of CD4+ T lymphocytes at pre-exposure (0-h) and post-exposure (2-h and 24-h) to anesthetic gas. P-value <0.05 denoted statistical significance.Results: Demographic data were comparable between groups. No statistical difference of peripheral blood Tregs between desflurane and sevoflurane groups observed at the baseline pre-exposure (3.6±0.4% vs. 3.1±0.4%; p=0.371) and 2-h post-exposure (3.0±0.3% vs. 3.5±0.4%; p=0.319). At 24-h post-exposure, peripheral blood Tregs was significantly higher in desflurane group (5.8±0.5% vs. 4.1±0.3%; p=0.008). Within group analysis showed patients receiving desflurane, but not sevoflurane, had 2.7% increase in peripheral blood Treg over 24-h period (p<0.001). Conclusion: This study provides the clinical trial-based evidence that desflurane induced peripheral blood Tregs increment after 24-h exposure, which could be beneficial in the context of kidney transplantation. Mechanisms of action and clinical advantages of desflurane anesthesia based on Treg immunomodulation should be investigated in the future. Trial registration: ClinicalTrials.gov, NCT02559297. Registered 22 September 2015 - retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT02559297
Bibliometric Analysis on the Comorbidity of Anxiety and Pain
Authors: Wu Cheng-Cheng , Hu Hao-Yu , Wang Xue-Qiang 
Published: June 2020

Abstract
Background: Pain is commonly associated with psychological variables, such as anxiety and depression. However, only a few studies statistically analyzed the global trends and conducted a review through the bibliometric method. Purpose: This work aimed to analyze the general aspects of scientific studies worldwide on the comorbid of anxiety and pain research between 2000 and 2019. Methods: Published papers on the comorbid of anxiety and pain from the last 2 decades were retrieved from the Web of Science core collection. To assess whether the percentage statistically decreased or increased over time by using IBM SPSS Statistics 22.0. Results: A total of 1,329 papers met the inclusion criteria. The trend of annual publications presented a significant growth from 2000 to 2019 (P<0.001) by linear regression analysis. Clinical Neurology, Neurosciences, and Anesthesiology of subject categories had superior quality and were recognized as mainstream on comorbid anxiety and pain research. The United States (416, 30.85%) and the University of Washington (23, 1.73%) were the most prolific and high-quality country and institution, respectively. Postoperative pain (11.81%) and headache (11.14%) were the hottest topic among researchers. Music, distraction, adult, dental anxiety, and preoperative anxiety were emerging hotspots and could be regarded as research frontiers. Conclusions: Bibliometric analysis of the comorbidity of anxiety and pain and provides insights into research countries, institutions, authors, and core journal, visual, hot topics, overall tendency, and research frontiers that will aid in exploring hidden valuable field for future research.
Multiprofessional Medication Management (MuMM) Intervention Aiming at Enhancing the Tolerability of Cancer Chemotherapy: A Randomized Feasibility Trial
Authors: Wilmer André , Vucur Corinna , Tasar Andrea , Klima Katharina , Fleckenstein Katrin , Puth Marie-Therese , Mitchell Sandra , Ruberg Klaus , Schmid Matthias , Ko Yon D. , Jaehde Ulrich 
Published: June 2020

Abstract
Background: A newly developed multiprofessional medication management (MuMM) intervention in an oncologic outpatient care setting was evaluated for its feasibility to enhance the tolerability of cancer-directed therapy. The intervention consisted of a basic care module for medication review including drug-drug interaction checks, and four supplementary modules for the management of common adverse events, specifically nausea/vomiting, mucositis, fatigue, and pain.Methods: A single-centre, unblinded, randomized two-arm trial was conducted in the oncologic outpatient ward of a municipal hospital in Bonn, Germany, with an associated community pharmacy. Feasibility of the intervention was assessed by analyzing the application of individual care modules and semi-structured interviews with the participating health care providers. Symptom burden was assessed by the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) using generalized estimating equation (GEE) models. Furthermore, health-related quality of life was analyzed.Results: 51 patients were randomized either to a control group receiving standard care (25 patients) or the intervention group receiving MuMM (26 patients). The results indicate that the MuMM intervention delivered by physicians, pharmacists, and nurses is needed and feasible, but hampered by several barriers concerning cooperation and communication within the multiprofessional health care team. The intervention did not affect symptom burden and quality of life.Conclusion: The degree of implementation of the MuMM intervention was apparently not high enough to show a preliminary efficacy signal. Nevertheless, our study provides a starting point and methodological framework for future trials aiming at enhancing the tolerability of cancer-directed therapy.TRIAL REGISTRATION NUMBERDRKS00010128 at the German Clinical Trials Register (DRKS) Date of registration: March 7th, 2016 (retrospectively registere
A coupled 1-D/2-D model for simulating river sediment transport and bed evolution
Authors: Salheddine Mezbache , André Paquier , Mahmoud Hasbaia 
Published: June 2020

AbstractThe paper details the method to couple a 1-D hydro-sedimentary model to a 2-D hydro-sedimentary model in order to represent the hydrodynamics and morphological processes during a flood event along a river. Tested on two field cases, the coupled model is stable even in the case of generalized overflow over the riverbanks or of levee breaching. For lateral coupling, the coupled model allows saving computational time compared to a full 2-D model and to provide valuable results concerning the flooding features as well as the evolution of the bed topography. However, despite a similar simplified representation of the sediment features in the 1-D and 2-D models, some discrepancies appear in the case of upstream/downstream coupling along a cross section perpendicular to the flow direction because the assumption of homogeneous velocity and concentration is not valid for estimating sediment transport. Further research is necessary to be able to define a suitable distribution of the sediments on the 1-D side of the boundary between the two models.
An improved routing algorithm for a large-scale distributed hydrological model with consideration of underlying surface impact
Authors: Li Jingjing , Zhao Haoyuan , Zhang Jun , Chen Hua , Xu Chong-Yu , Li Lu , Chen Jie , Guo Shenglian 
Published: June 2020

Abstract
Large-scale hydrological models are important tools for simulating the hydrological effect of climate change. As an indispensable part of the application of distributed hydrological models, large-scale flow routing methods can simulate not only the discharge at the outlet but also the temporal and spatial distribution of flow. The aggregated network-response function (NRF), as a scale-independent routing method, has been tested in many basins and demonstrated to have good runoff simulation performance. However, it had a poor performance and produced an unreasonable travel time when it was applied to certain basins due to a lack of consideration of the influence of the underlying surface. In this study, we improve the NRF routing method by combining it with a velocity function using a new routing parameter b to reflect the wave velocity's sensitivity to slope. The proposed method was tested in 15 catchments at the Yangtze River basin. The results show that it can provide better daily runoff simulation performance than the original routing model and the calibrated travel times in all catchments are more reasonable. Therefore, our proposed routing method is effective and has great potential to be applied to other basins.
Drought prediction models driven by meteorological and remote sensing data in Guanzhong Area, China
Authors: Li Jianzhu , Zhang Siyao , Huang Lingmei , Zhang Ting , Feng Ping 
Published: June 2020

AbstractDrought is an important factor that limits economic and social development due to its frequent occurrence and profound influence. Therefore, it is of great significance to make accurate predictions of drought for early warning and disaster alleviation. In this paper, SPEI-1 was confirmed to classify drought grades in the Guanzhong Area, and the autoregressive integrated moving average (ARIMA), random forest (RF) and support vector machine (SVM) model were established. Meteorological data and remote sensing data were used to derive the prediction models. The results showed the following. (1) The SVM model performed the best when the models were developed using meteorological data, remote sensing data and a combination of meteorological and remote sensing data, but the model's corresponding kernel functions are different and include linear, polynomial and Gaussian radial basis kernel functions, respectively. (2) The RF model driven by the remote sensing data and the SVM model driven by the combined meteorological and remote sensing data were found to perform better than the model driven by the corresponding other data in the Guanzhong Area. It is difficult to accurately measure drought with the single meteorological data. Only by considering the combined factors can we more accurately monitor and predict drought. This study can provide an important scientific basis for regional drought warnings and predictions.
Heterogeneous Fenton-like degradation of EDTA in an aqueous solution with enhanced COD removal under neutral pH
Authors: Hua Junfeng , Huang Mei 
Published: June 2020

Abstract
By providing the key carbon and nitrogen elements needed for eutrophication, the potential toxicity of ethylenediaminetetraacetic acid (EDTA) prompts the exploration of effective treatment methods to minimize the amount of EDTA released into the environment. In this study, Fe3O4 magnetic nanoparticles (MNPs) were prepared and used as catalysts to study the mineralization of EDTA in Fenton-like reactions under neutral pH. Fe3O4 MNPs were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET). The effects of pH, ferric ion leaching, and H2O2 concentration on chemical oxygen demand (COD) removal of EDTA were investigated. The morphological characterization of the nanoparticles suggests a quasi-spherical structure with small particle size and a surface area of 49.9 m2/g. The results show that Fe3O4 MNPs had good catalytic activity for the mineralization of EDTA under pH 5.0–9.0. The optimum conditions for the COD removal of 45% at pH 7.0 were: 40 mM H2O2, 10 mM Fe3O4, and 1 g/L EDTANa2·2H2O at 303 K. Fe3O4 MNPs maintained high catalytic activity after five cycles of continuous degradation of EDTA. According to reactive oxidizing species measurements obtained by electron spin resonance (ESR), it was confirmed that HO· free radicals, presented in the H2O2/Fe3O4 MNPs heterogeneous Fenton-like reaction, were the primary active group in the removal of EDTA. These features can be considered beneficial to the application of Fe3O4 MNPs towards industrial wastewater treatment.
Higher Levels of Dynamin-related Protein 1 are Associated with Reduced Radiation Sensitivity of Glioblastoma Cells
Authors: Cheng Wen-Yu , Chow Kuan-Chih , Chiao Ming-Tsang , Yang Yi-Chin , Shen Chiung-Chyi 
Published: June 2020

Background:
Dynamin-related protein 1 (DRP1) is a GTPase involved in mitochondrial
fission, mitochondrial protein import, and drug sensitivity, suggesting an association with cancer
progression. This study was conducted to evaluate the prognostic significance of DRP1 in glioblastoma
multiforme (GBM).

Methods:
DRP1 expression was measured by immunohistochemistry and Western blotting. Correlations
between DRP1 expression and clinicopathological parameters were determined by statistical
analysis. Differences in survival were compared using the log-rank test. DRP1 expression was
detected in 87.2% (41/47) of the investigated patients with GBM.

Results:
The patients with higher DRP1 levels had worse survival (p = 0.0398). In vitro, the silencing
of DRP1 reduced cell proliferation, invasive potential, and radiation resistance. The addition of
shikonin inhibited DRP1 expression and increased drug uptake. Moreover, shikonin reduced the nuclear
entry of DNA repair-associated enzymes and increased radiation sensitivity, suggesting that
reducing DRP1 expression could inhibit DNA repair and increase the radiation sensitivity of GBM
cells.

Conclusion:
Our results indicate that DRP1 overexpression is a prospective radio-resistant phenotype
in GBM. Therefore, DRP1 could be a potential target for improving the effectiveness of radiation
therapy.