bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural underpinnings of the relationships between sensation seeking and emotion regulation in adolescents
Authors: Deng Xinmei , Zhang Lin 
Published: December 2019

There is little neurological evidence linking sensation seeking and emotion regulation in adolescence, which is characterised as an emotionally fluctuant period. The present study examined the relationship between sensation seeking and emotion regulation in adolescents. Electroencephalograms were recorded from 22 high sensation‐seeking adolescents (HSSs, Mage = 12.36) and 24 low sensation‐seeking adolescents (LSSs, Mage = 12.84) during the reactivity and regulation‐image task. Group differences in event‐related brain potentials (ERPs) associated with the regulation of negative and neutral stimuli were analysed. The results showed that (a) the P2 of HSSs were larger than LSSs during emotion regulation; (b) in down‐regulation conditions, the LPP in all time windows were smaller than no‐regulation in LSSs. However, there was no significant difference in HSSs; (c) the LPP 300–600 and LPP 1000–1500 of down‐regulation were smaller in LSSs than HSSs; (d) for LPP 600–1000, HSSs induced larger LPP than LSSs in the negative down‐regulation and negative no‐regulation conditions. The results provide neurological evidence that higher sensation seeking is related to the high reactivity to emotional stimuli and poor cognitive control during the regulation of emotions.
Literacy Leadership Learnings From a Large‐Scale Program With Mixed Results
Authors: Wilson Aaron , McNaughton Stuart 
Published: December 2019

AbstractThis department focuses on literacy leaders, including school and instructional leaders, teachers, and external partners, who are working to improve outcomes for adolescent and adult learners in a wide range of education settings. Columns investigate the challenges and complexities inherent in such work and share lessons learned, impactful strategies and approaches, and promising pathways forward.
Effect of multipurpose care solutions upon physical dimensions of silicone hydrogel contact lenses
Authors: Smith Stephanie M. , Zhu Dongkai , Pierre David , Gilbert Jeremy L. , Chinn Joseph A. 
Published: December 2019

AbstractInteractions between contact lens multipurpose solution (MPS) components and the contact lenses with which they are used are both lens and solution dependent. As such, lens dimensional changes may arise after cleaning and immersion cycling in different lens care solutions over different time courses. In this study, the dimensional stability of five planned‐replacement silicone hydrogel lenses (lotrafilcon B, comfilcon A, senofilcon A, senofilcon C, and samfilcon A) over 30 cycles in three different MPSs (Biotrue, OPTI‐FREE Express, and OPTI‐FREE Puremoist) was evaluated. Measurements of diameter, sagittal depth, power, roundness, and center thickness were obtained prior to, during, and after 30 cycles of cleaning and storage. Diameters of all lenses increased when soaked in Express or Biotrue but held the International Standards Organization (ISO) tolerance over the full course of 30 disinfection cycles; however, the diameters of comfilcon A, senofilcon A, senofilcon C, and samfilcon A lenses soaked in Puremoist exceeded ISO tolerance after between 4 and 9 immersion cycles. In contrast, the diameter of lotrafilcon B held tolerance. Similarly, all lenses cycled in Express or Biotrue held tolerance for sagittal depth, while in Puremoist only lotrafilcon B held tolerance. All lenses became less round in all MPSs but held tolerance for both power and central thickness. Given the lack of reported clinical issues with Puremoist when used with lenses other than lotrafilcon B, we propose that it may be appropriate to revisit the ISO test methods and tolerances to determine if they are still applicable for silicone hydrogel lenses.
Disorder of Iron Metabolism Inhibits the Recovery of Unloading-Induced Bone Loss in Hypomagnetic Field
Authors: Xue Yanru , Yang Jiancheng , Luo Jie , Ren Li , Shen Ying , Dong Dandan , Fang Yanwen , Hu Lijiang , Liu Mengyu , Liao Zhongcai , Li Jun , Fang Zhicai , Shang Peng 
Published: December 2019

ABSTRACT
Exposure of humans and animals to microgravity in spaceflight results in various deleterious effects on bone health. In addition to microgravity, the hypomagnetic field (HyMF) is also an extreme environment in space, such as on the Moon and Mars; magnetic intensity is far weaker than the geomagnetic field (GMF) on Earth. Recently, we showed that HyMF promoted additional bone loss in hindlimb unloading–induced bone loss, and the underlying mechanism probably involved an increase of body iron storage. Numerous studies have indicated that bone loss induced by mechanical unloading can be largely restored after skeletal reloading in GMF conditions. However, it is unknown whether this bone deficit can return to a healthy state under HyMF condition. Therefore, the purpose of this study is to examine the effects of HyMF on the recovery of microgravity-induced bone loss, and illustrates the changes of body iron storage in this process. Our results showed that there was lower bone mineral content (BMC) in the HyMF reloading group compared to the GMF reloading group. Reloaded mice in the HyMF condition had a worse microstructure of femur than in the GMF condition. Femoral mechanical properties, including elastic modulus, stiffness, and ultimate stress, were poorer and toughness was higher in the HyMF group compared with the GMF group. Simultaneously, more iron content in serum, the tibia, liver, and spleen was found under HyMF reloading than GMF reloading. The iron chelator deferoxamine mesylate (DFO) decreased the iron content in the bone, liver, and spleen, and significantly relieved unloading-induced bone loss under HyMF reloading. These results showed that HyMF inhibits the recovery of microgravity-induced bone loss, probably by suppressing the elevated iron levels’ return to physiological level. © 2019 American Society for Bone and Mineral Research.
Propranolol Reverses Impaired Fracture Healing Response Observed With Selective Serotonin Reuptake Inhibitor Treatment
Authors: Lee Sooyeon , Remark Lindsey H , Buchalter Daniel B , Josephson Anne M , Wong Madeleine Z , Litwa Hannah P , Ihejirika Rivka , Leclerc Kevin , Markus Danielle , Yim Nury L , Tejwani Ruchi , Bradaschia-Correa Vivian , Leucht Philipp 
Published: December 2019

ABSTRACT
Selective serotonin reuptake inhibitors (SSRIs) are one of the most commonly prescribed antidepressants worldwide and recent data show significant impairment of fracture healing after treatment with the SSRI fluoxetine in mice. Here, we provide evidence that the negative effects of SSRIs can be overcome by administration of the beta-blocker propranolol at the time of fracture. First, in vitro experiments established that propranolol does not affect osteogenic differentiation. We then used a murine model of intramembranous ossification to study the potential rescue effect of propranolol on SSRI-induced impaired fracture healing. Micro-CT analysis revealed that fluoxetine treatment resulted in a smaller bony regenerate and that this decrease in bone formation can be overcome by co-treatment with propranolol. We then tested this in a clinically relevant model of endochondral ossification. Fluoxetine-treated mice with a femur fracture were treated with propranolol initiated at the time of fracture, and a battery of analyses demonstrated a reversal of the detrimental effect of fluoxetine on fracture healing in response to propranolol treatment. These experiments show for the first time to our knowledge that the negative effects of SSRIs on fracture healing can be overcome by co-treatment with a beta-blocker. © 2019 American Society for Bone and Mineral Research.
Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation
Authors: Liu Yuejian , Badée Justine , Takahashi Ryan H. , Schmidt Stephan , Parrott Neil , Fowler Stephen , Mackenzie Peter I. , Coughtrie Michael W. H. , Collier Abby C. 
Published: December 2019

AbstractUridine diphosphate glucuronosyltransferases (UGTs) catalyze glucuronidation to facilitate systemic and local clearance of numerous chemicals and drugs. To investigate whether UGT expression is coregulated in human liver, we analyzed the protein expression of UGTs 1A1, 1A3, 1A4, 1A6, 1A9, 2B7, 3A1, and 3A2 using western blots from 164 healthy human liver samples, comparing expression with age and sex. UGT1A6 levels were significantly higher in children than adults, and UGT3A1 and 3A2 expression significantly increased with age from childhood to age >65 yearas. In children aged <18 years, UGT1A4/1A9 protein expression was significantly correlated, but not for adults aged >18 years. UGT1A3 expression was always significantly correlated with other UGT1A isoforms in all adults aged >18 years. In individuals aged ≥12 years, expression of UGT1A1/1A4, UGT1A1/1A6, UGT1A1/1A9, and UGT1A4/1A6 significantly correlated, which was not observed in children aged <12 years. In contrast, UGT1A4/2B7 showed significant correlation in children aged <12 years, but not in individuals aged ≥12 years, and this was observed in female but not male individuals. Expression of UGT1A6/1A9 and UGT3A1/3A2 correlated in the entire sample population, but UGT3As did not correlate with other UGTs. These correlations were sex dependent, as UGT1A3/1A1, UGT1A4/2B7 and UGT3A1/3A2 correlated more highly in male than female individuals, while UGT1A4/1A6 protein correlated more significantly in female than male individuals. This is the first report on the ontogeny of UGT3A isoforms, showing maximal expression in the elderly, and is the first demonstration that UGT isoforms commonly coexpress in vivo, in both age‐dependent and sex‐dependent manners.
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy
Authors: Signorelli Mirko , Ayoglu Burcu , Johansson Camilla , Lochmüller Hanns , Straub Volker , Muntoni Francesco , Niks Erik , Tsonaka Roula , Persson Anja , Aartsma‐Rus Annemieke , Nilsson Peter , Al‐Khalili Szigyarto Cristina , Spitali Pietro 
Published: December 2019

AbstractBackgroundDuchenne muscular dystrophy (DMD) is a fatal disease for which no cure is available. Clinical trials have shown to be largely underpowered due to inter‐individual variability and noisy outcome measures. The availability of biomarkers able to anticipate clinical benefit is highly needed to improve clinical trial design and facilitate drug development.MethodsIn this study, we aimed to appraise the value of protein biomarkers to predict prognosis and monitor disease progression or treatment outcome in patients affected by DMD. We collected clinical data and 303 blood samples from 157 DMD patients in three clinical centres; 78 patients contributed multiple blood samples over time, with a median follow‐up time of 2 years. We employed linear mixed models to identify biomarkers that are associated with disease progression, wheelchair dependency, and treatment with corticosteroids and performed survival analysis to find biomarkers whose levels are associated with time to loss of ambulation.ResultsOur analysis led to the identification of 21 proteins whose levels significantly decrease with age and nine proteins whose levels significantly increase. Seven of these proteins are also differentially expressed in non‐ambulant patients, and three proteins are differentially expressed in patients treated with glucocorticosteroids. Treatment with corticosteroids was found to partly counteract the effect of disease progression on two biomarkers, namely, malate dehydrogenase 2 (MDH2, P = 0.0003) and ankyrin repeat domain 2 (P = 0.0005); however, patients treated with corticosteroids experienced a further reduction on collagen 1 serum levels (P = 0.0003), especially following administration of deflazacort. A time to event analysis allowed to further support the use of MDH2 as a prognostic biomarker as it was associated with an increased risk of wheelchair dependence (P = 0.0003). The obtained data support the prospective evaluation of the identified biomarkers in natural history and clinical trials as exploratory biomarkers.ConclusionsWe identified a number of serum biomarkers associated with disease progression, loss of ambulation, and treatment with corticosteroids. The identified biomarkers are promising candidate prognostic and surrogate biomarkers, which may support drug developers if confirmed in prospective studies. The serum levels of MDH2 are of particular interest, as they correlate with disease stage and response to treatment with corticosteroids, and are also associated with the risk of wheelchair dependency and pulmonary function.
SBA‐15‐Pr‐SO3H catalyzed one‐pot synthesis of indole derivatives via Fischer indole pathway
Authors: Ghiyasabadi Zahra , Bahadorikhalili Saeed , Saeedi Mina , Karimi‐Niyazagheh Mona , Mirfazli Seyedeh Sara 
Published: December 2019

AbstractIn this work, an efficient, user‐friendly, and simple procedure was reported for the preparation of indole derivatives catalyzed by the heterogeneous SBA‐15‐Pr‐SO3H via Fischer indole pathway. The title compounds were synthesized from various arylhydrazines and ketones in the presence of 3 mol% of the catalyst in the refluxing ethanol.
Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis
Authors: Kanda Márcia Helena , da Costa Vieira René Aloisio , Lima João Paulo S. N. , Paiva Carlos Eduardo , de Araujo Raphael Leonardo Cunha 
Published: December 2019

AbstractThis systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associated with an increased risk of capsular contracture and decreased the mobility of the upper limb. A borderline association of lymphedema risk using RT was noted in the random‐effects model but was significant in the fixed‐effects model.
Characterization of a Type‐2 Diacylglycerol Acyltransferase from Haematococcus pluvialis Reveals Possible Allostery of the Recombinant Enzyme
Authors: Nguyen Trinh , Xu Yang , Abdel‐Hameed Mona , Sorensen John L. , Singer Stacy D. , Chen Guanqun 
Published: December 2019

AbstractHaematococcus pluvialis is a green microalga used in the algal biotechnology industry that can accumulate considerable amounts of storage triacylglycerol (TAG) and astaxanthin, which is a high‐value carotenoid with strong antioxidant activity, under stress conditions. Diacylglycerol acyltransferase (DGAT) catalyzes the last step of the acyl‐CoA‐dependent TAG biosynthesis and appears to represent a bottleneck in algal TAG formation. In this study, putative H. pluvialis DGAT2 cDNA (HpDGAT2A, B, D and E) were identified from a transcriptome database and were subjected to sequence‐based in silico analyses. The coding sequences of HpDGAT2B, D, and E were then isolated and characterized through heterologous expression in a TAG‐deficient Saccharomyces cerevisiae strain H1246. The expression of HpDGAT2D allowed the recovery of TAG biosynthesis in this yeast mutant, and further in vitro enzymatic assays confirmed that the recombinant HpDGAT2D possessed strong DGAT activity. Interestingly, the recombinant HpDGAT2D displayed sigmoidal kinetics in response to increasing acyl‐CoA concentrations, which has not been reported in plant or algal DGAT2 in previous studies.
Chitosan Microspheres as Carriers for pH‐Indicating Species in Corrosion Sensing
Authors: Sousa Isabel , Quevedo Marcela C. , Sushkova Alesia , Ferreira Mário G. S. , Tedim João 
Published: December 2019

AbstractChitosan microspheres containing bromocresol green, cresol red, and phenolphthalein for corrosion detection, through pH change, are synthesized in order to be used in protective coatings for aluminium alloys. Microspheres containing corrosion detection species are characterized morphologically (SEM) and physico‐chemically (FTIR, TGA). Release studies (UV–vis) are performed in corrosion‐promoting conditions (pH, NaCl), and detection studies by immersion in media associated with corrosion activity while microspheres' sensing activity is evaluated visually. Electrochemical characterization of AA2024 substrates in the presence of chitosan spheres is performed to understand material performance, and a color change is observed as a result of local pH increase in cathodic areas when corrosion takes place. These findings can be correlated with the results from release studies and seem a promising approach for corrosion sensing purposes, not only because pH increase is possible to detect due to corrosion, but also because chitosan is considered an environmentally friendly material.
Large deviations for intersection measures of some Markov processes
Authors: Mori Takahiro 
Published: December 2019

AbstractConsider an intersection measure of p independent (possibly different) m‐symmetric Hunt processes up to time t in a metric measure space E with a Radon measure m. We derive a Donsker–Varadhan type large deviation principle for the normalized intersection measure on the set of finite measures on E as , under the condition that t is smaller than life times of all processes. This extends earlier work by W. König and C. Mukherjee [16], in which the large deviation principle was established for the intersection measure of p independent N‐dimensional Brownian motions before exiting some bounded open set . We also obtain the asymptotic behavior of logarithmic moment generating function, which is related to the results of X. Chen and J. Rosen [7] on the intersection measure of independent Brownian motions or stable processes.Our results rely on assumptions about the heat kernels and the 1‐order resolvents of the processes, hence include rich examples. For example, the assumptions hold for with when the processes enjoy (sub‐)Gaussian type or jump type heat kernel estimates, where is determined by the Hausdorff dimension of E and the so‐called walk dimensions of the processes.
Organic–Inorganic Nanocomposite Film for High‐Performance Stretchable Resistive Memory Device
Authors: Wu Ping‐Han , Lin Yan‐Cheng , Laysandra Livy , Lee Meng‐Hsien , Chiu Yu‐Cheng , Isono Takuya , Satoh Toshifumi , Chen Wen‐Chang 
Published: December 2019

AbstractA compatible organic/inorganic nanocomposite film for a stretchable resistive memory device with high performance is demonstrated using poly(4‐vinylpyridine)‐block‐poly(propyl methacrylate) (P4VP‐b‐PPMA) with zinc oxide (ZnO) nanoparticle. The PPMA soft segment is designed for reducing the rigidity of the active layer, while the P4VP block serves as a charge‐trapping component to induce conductive filament and also a compatible moiety for inorganic nanoparticles through hydrogen bonding. The experimental results show that the P4VP‐b‐PPMA‐based electrical memory device exhibits write‐once‐read‐many‐times memory behavior and an excellent ON/OFF current ratio of over 105 with a stable turn‐on voltage (Vset) around −2.0 V and stable memory behavior upon stretching up to 60% strain. On the other hand, P4VP‐b‐PPMA/ZnO nanocomposite film switches the memory characteristic to the dynamic random access memory behavior. The stretchable memory device prepared from the nanocomposite film can have a stretching durability over 40% strain and up to 1000 times cycling stretch–relaxation test. This work demonstrates a new strategy using nanocomposite films with tunable electrical characteristics and enhanced mechanical properties for stretchable electrical devices.
An Efficient Ring‐Closure Method for Preparing Well‐Defined Cyclic Polynorbornenes
Authors: Zhang Minghui , Wu Ying , Liu Zhengping , Li Jun , Huang Liyan , Zhang Ke 
Published: December 2019

AbstractAn efficient bimolecular ring‐closure method is developed to prepare the well‐defined cyclic polynorbornenes by combining the living ring‐opening metathesis polymerization (ROMP) with the self‐accelerating double strain‐promoted azide–alkyne cycloaddition (DSPAAC) reaction. In this method, ROMP is used to synthesize the well‐defined linear polynorbornenes with both azide terminals by virtue of a N‐hydroxysuccinimide‐ester‐functionalized Grubbs initiator following the modification of polymer end groups. DSPAAC click reaction is then used to ring‐close the linear polymer precursors and prepare the corresponding well‐defined cyclic polynorbornenes using the sym‐dibenzo‐1,5‐cyclooctadiene‐3,7‐diyne (DIBOD) as small linkers. The self‐accelerating DSPAAC ring‐closing reaction facilitates this method to efficiently prepare pure cyclic polynorbornenes in the presence of a molar excess of DIBOD small linkers to the linear polynorbornene precursors. This is the first report to prepare well‐defined polynorbornenes with cyclic topology based on the ring‐closure strategy for cyclic polymers.
Single‐nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility
Authors: Rafaee Alemeh , Mohseni Meybodi Anahita , Yaghmaei Parichehreh , Hosseini Seyedeh Hanieh , Sabbaghian Marjan 
Published: December 2019

AbstractSEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells. SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental constituent of sperm tail annulus. In this study, we screened genetic variations in exons 5, 6, 7 of the SEPT12 and assessed the annulus status in teratozoospermic, globozoospermic, and patients with immotile short tail sperm.DNA sequencing was performed for 90 teratozoospermic and 30 normozoospermic individuals. Immunocytochemistry, transmission electron microscopy and western blotting were conducted to evaluate annulus status and the expression level of SEPT12 in patients with a distinct exonic variation (c.474G>A), respectively.Five polymorphisms identified within the desired regions of the SEPT12, among them c.474G>A had the potential to induce aberrant splicing results in the expression of a truncated protein. The annulus was detected in most of the spermatozoa from teratozoospermic and normozoospermic men with c.474G>A. In contrast, in the patient with short tail sperm defect carrying c.474G>A, 99% of spermatozoa were devoid of the annulus. Based on our findings there would be no association between exons 5, 6, 7 polymorphisms of the SEPT12 gene and the occurrence of mentioned disease but c.474G>A would be a predisposing factor in male infertility.