bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granulocyte colony‐stimulating factor producing retroperitoneal leiomyosarcoma
Authors: Fukuta Kyotaro , Daizumoto Kei , Takahashi Masayuki , Mori Hidehisa , Otomi Yoichi , Uehara Hisanori , Fukawa Tomoya , Yamamoto Yasuyo , Yamaguchi Kunihisa , Kanayama Hiro‐omi 
Published: December 2020

IntroductionGranulocyte colony‐stimulating factor‐producing nonhematopoietic malignancies have poor clinical outcomes.Case presentationA 62‐year‐old woman complaining of fever and left lower quadrant pain was referred to our hospital. A left retroperitoneal tumor was suspected on computed tomography, and laboratory data showed leukocytosis and markedly elevated granulocyte colony‐stimulating factor. She underwent left nephroureterectomy, partial colectomy, and psoas muscle resection. The histological examination showed a granulocyte colony‐stimulating factor‐producing retroperitoneal leiomyosarcoma. Three months after the operation, she developed lung and liver metastases and received the chemotherapy, including doxorubicin and ifosfamide. Eight months after the operation, these lesions had progressed, and a new bone metastasis appeared. Twelve months after the operation, she received pazopanib and radiation for bone metastases. However, the metastases progressed, and she died 17 months after the operation.ConclusionSince granulocyte colony‐stimulating factor‐producing retroperitoneal leiomyosarcoma had a very poor prognosis irrespective of intensive treatment including wide resection, effective systemic therapy should be required.
“As We Talk About This More, a Box Opens Up”: Family Literacy Programs for Fathers in Treatment for Substance Use Disorder
Authors: Wiseman Angela M. , Atkinson Ashley A. , Cryer‐Coupet Qiana R. 
Published: December 2020

AbstractParenting while transitioning out of incarceration, homelessness, or drug addiction has received inadequate attention despite the fact that these factors affect more and more of the U.S. population each day. This article is about a family literacy program implemented in a residential treatment facility where the fathers, most of whom were previously incarcerated and now receiving treatment for substance use disorder, have been parenting from afar with limited access to their children. Fathers participated in a family literacy program where they respond to children’s literature with the intention of eventually reading with their children. Our research was guided by the following question: How do fathers who are separated from their children while in a residential treatment program, read and respond to children’s literature in a small‐group setting? Findings reflect how fathers wanted to share their feelings about parenting and also consider their identities as fathers who were also addicts.
Comparison of four commercial RT‐PCR diagnostic kits for COVID‐19 in China
Authors: Shen Lingyu , Cui Shujuan , Zhang Daitao , Lin Changying , Chen Lijuan , Wang Quanyi 
Published: December 2020

AbstractWe compared the sensitivity and specificity of four commercial coronavirus disease (COVID‐19) diagnostic kits using real‐time reverse transcription–polymerase chain reaction (RT‐PCR). Kits I‐IV approved by the State Drug Administration of China were selected, and the detection targets were ORF1ab gene and N gene. Specificity was evaluated by detecting other respiratory viruses. The sensitivity and batch effect of each kit were evaluated by testing 10‐fold dilutions of RNA. Clinical application was verified by testing nasopharyngeal swab and sputum specimens from COVID‐19 patients. Among the 78 cases infected by other respiratory viruses, no amplification curve was observed using these four COVID‐19 RT‐PCR kits. The minimum detection limits of kits I‐IV were 10−6, 10−5, 10−5, and 10−6dilutions, respectively, and concentrations were 10 copies/mL (10−5dilution) and 1 copies/mL (10−6dilution). The sensitivities of kits I‐IV detected using 142 nasopharyngeal swab specimens from COVID‐19 patients were 91.55%, 81.69%, 80.28%, and 90.85%, respectively, while they were 92.68%, 85.37%, 82.93%, and 93.90%, respectively, for the 82 sputum samples. The specificity of each kit was 100.00% (77/77). The total expected detection rate using sputum samples was 88.59% (691/780) higher than 86.15% (672/780) of nasopharyngeal swabs. Comparison of nasopharyngeal swab and sputum samples from the same COVID‐19 patient led to the detection of ORF1ab and N genes in 16 (100%) sputum samples; only ORF1ab and N genes were detected in 12 (75%) and 14 (87.5%) nasopharyngeal swab specimens, respectively. In conclusion, comparison of commercial COVID‐19 RT‐PCR kits should be performed before using a new batch of such kits in routine diagnostics.
Tissue engineering of the larynx: A contemporary review
Authors: Chen Jingjing , Shen Yi , Shen Zhisen , Cheng Lixin , Zhou Shuihong 
Published: December 2020

AbstractObjectiveTissue engineering has been a topic of extensive research in recent years and has been applied to the regeneration and restoration of many organs including the larynx. Currently, research investigating tissue engineering of the larynx is either ongoing or in the preclinical trial stage.MethodsA literature search was performed on the Advanced search field of PubMed using the keywords: “(laryncheal tissue engineering) AND (cartilage regeneration OR scaffolds OR stem cells OR biomolecules).” After applying the selection criteria, 65 articles were included in the study.ResultsThe present review focuses on the rapidly expanding field of tissue‐engineered larynx, which aims to provide stem cell–based scaffolds combined with biological active factors such as growth factors for larynx reconstruction and regeneration. The trend in recent studies is to use new techniques for scaffold construction, such as 3D printing, are developed. All of these strategies have been instrumental in guiding optimization of the tissue‐engineered larynx, leading to a level of clinical induction beyond the in vivo animal experimental phase.ConclusionsThis review summarizes the current progress and outlines the necessary basic components of regenerative laryngeal medicine in preclinical fields. Finally, it considers the design of scaffolds, support of growth factors, and cell therapies toward potential clinical application.
Indirect experiences with domestic violence and help‐seeking preferences among south asian immigrants in the United States
Authors: Rai Abha 
Published: December 2020

AbstractThe South Asian culture disempowers individuals experiencing domestic violence (DV) from reporting victimization. Past research has found that confiding in and seeking help from friends/family is preferred. Therefore, it is important to gauge the knowledge of community members who may be contacted for support by victims. The goal of the study was to examine indirect experience with DV (knowing someone who experienced DV) and help‐seeking resource preference among community members. This cross‐sectional study included a sample of 468 South Asian men and women. Descriptive statistics were used to establish rates of indirect experience with DV. Hierarchical logistic regression was used to examine the correlates of recommending help‐seeking. The overall findings suggested that community members knew more women than men who were victims. Of nine help‐seeking resources, medical professionals were preferred. Regression findings identified gender, religiosity, generational position, family type, and gender‐role attitudes as the correlates of recommending help‐seeking. The study findings are beneficial in developing bystander interventions for use by community members to support their friends and family members who may be victims of DV. To reduce overall victimization, it is imperative for agencies to engage with community members along with victims.
Pharmacokinetics and Pharmacodynamics of Tegoprazan Coadministered With Amoxicillin and Clarithromycin in Healthy Subjects
Authors: Ghim Jong‐Lyul , Chin May Chien , Jung Jinah , Lee Jiwon , Kim Seokuee , Kim Bongtae , Song Geun Seog , Choi Young‐Kyung , Shin Jae‐Gook 
Published: December 2020

AbstractThis clinical trial was conducted to evaluate the pharmacokinetics and pharmacodynamics of tegoprazan when coadministered with amoxicillin/clarithromycin in healthy subjects. Cohort 1 was an open‐label, randomized multiple‐dose study to evaluate the mutual interaction of tegoprazan and amoxicillin/clarithromycin on the disposition of 3 tested drugs including tegoprazan M1 metabolite and 14‐hydroxyclarithromycin (14‐OH‐clarithromycin). Cohort 2 was an open‐label, randomized, active‐controlled, parallel multiple‐dose study to compare the intragastric pH profile after multiple oral doses of 50 or 100 mg tegoprazan coadministered with amoxicillin/clarithromycin 1000/500 mg for 7 days and pantoprazole‐based triple therapy as the comparator arm. The coadministration of tegoprazan with amoxicillin/clarithromycin increased Css,max (2.2‐fold) and AUCτ (2.7‐fold) of tegoprazan and M1 (2.1‐ and 2.2‐fold for Css,max and AUCτ, respectively) compared with administration of tegoprazan alone. The Css,max and AUCτ of 14‐OH‐clarithromycin increased by 1.7‐ and 1.8‐fold, respectively; the disposition of amoxicillin and clarithromycin were not significantly changed. On days 1 and 7 of treatment, tegoprazan‐based therapies (both 50‐ and 100‐mg therapies) maintained pH above 6 for more than 88% of the 24‐hour period, which was significantly longer compared with pantoprazole‐based therapy. Tegoprazan either alone or in combination with amoxicillin/clarithromycin was well tolerated in healthy subjects. In conclusion, the exposure of tegoprazan was increased after coadministration of amoxicillin/clarithromycin, which led to increase pharmacodynamic response measured by intragastric pH compared with tegoprazan alone. Therefore, tegoprazan‐based triple therapy would be effective therapeutic regimen to manage intragastric pH in terms of gastric or duodenal ulcers healing, treatment of gastroesophageal reflux disease, and Helicobacter pylori eradication.
Fabrication of recoverable magnetic composite material based on graphene oxide for fast removal of lead and cadmium ions from aqueous solution
Authors: Hou Li , Qin Guangjiong , Qu Yaqing , Yang Chunlei , Rao Xiongfei , Gao Yun , Zhu Xiaolan 
Published: December 2020

AbstractBACKGROUNDIn this study, a novel magnetic material was applied as an adsorbent for simultaneous removal of Pb(II) and Cd(II) ions from aqueous solutions. The adsorbent was synthesized using functionalized MnFe2O4 magnetic nanoparticles grafted to lamellar graphene oxide surface (MnFe2O4@SiO2‐NH2@GO) and characterized using X‐ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and magnetic measurements.RESULTSThe adsorbent exhibited superior adsorption properties for Pb(II) and Cd(II). The maximum uptake capacity of Pb(II) and Cd(II) reached 42.48 and 18.28 mg g−1 within 30 min at 25 °C, respectively. The data for adsorption fitted well with the Langmuir isotherm and pseudo‐second‐order kinetic models, which indicated that the adsorption was via monolayer chemisorption on homogeneous sites. The calculation of thermodynamic parameters revealed spontaneous and endothermic adsorption processes accompanied by randomness increase. X‐ray photoelectron spectroscopy analysis indicated that the coordination between nitrogen atoms of amino groups and the two types of heavy metal ions was a possible adsorption mechanism.CONCLUSIONSMnFe2O4@SiO2‐NH2@GO possesses the properties of high adsorption efficiency, fast separation, high stability and easy regeneration for adsorption of Pb(II) and Cd(II) ions. Thus, the as‐prepared adsorbent is considered as a promising material for the removal of heavy metal ions and this research could offer a new means for water cleanup. © 2020 Society of Chemical Industry
Exome sequencing study in a clinical research setting finds general acceptance of study returning secondary genomic findings with little decisional conflict
Authors: Similuk Morgan N. , Yan Jia , Setzer Michael R. , Jamal Leila , Littel Patricia , Lenardo Michael , Su Helen C. 
Published: December 2020

AbstractThe most appropriate strategies for managing secondary genomic findings (SF) in clinical research are being developed and evaluated. We surveyed patients at the National Institute of Allergy and Infectious Diseases (NIAID) to evaluate decisional conflict regarding enrolling in a study that returns SF. Responses were collected using a cross‐sectional survey after informed consent but before return of SF. Sixty‐six adults of 116 eligible participants responded. No participant explicitly declined because they did not want to possibly receive a SF. Sixty‐five of 66 (98%) participants thought it was appropriate to return SFs in research; one participant was unsure. Decisional conflict regarding enrolling in a study returning SF was low overall with 68% of participants reporting a score of less than 10 on a 100‐point decisional conflict scale, implying that they felt informed, clear on what they wanted, and supported. Lower genetic literacy was weakly associated with higher decisional conflict (Spearman's rho = −0.297, p = .015). Six participants reported confusion related to the choices about SFs. Our data suggest that participants in our study feel it is appropriate to receive SF and have little decisional conflict about potentially receiving such information; however, some participants may need further education and counseling.
Expanding the clinical and molecular spectrum of ATP6V1A related metabolic cutis laxa
Authors: Vogt Guido , El Choubassi Naji , Herczegfalvi Ágnes , Kölbel Heike , Lekaj Anja , Schara Ulrike , Holtgrewe Manuel , Krause Sabine , Horvath Rita , Schuelke Markus , Hübner Christoph , Mundlos Stefan , Roos Andreas , Lochmüller Hanns , Karcagi Veronika , Kornak Uwe , Fischer‐Zirnsak Björn 
Published: December 2020

AbstractSeveral inborn errors of metabolism show cutis laxa as a highly recognizable feature. One group of these metabolic cutis laxa conditions is autosomal recessive cutis laxa type 2 caused by defects in v‐ATPase components or the mitochondrial proline cycle. Besides cutis laxa, muscular hypotonia and cardiac abnormalities are hallmarks of autosomal recessive cutis laxa type 2D (ARCL2D) due to pathogenic variants in ATP6V1A encoding subunit A of the v‐ATPase. Here, we report on three affected individuals from two families with ARCL2D in whom we performed whole exome and Sanger sequencing. We performed functional studies in fibroblasts from one individual, summarized all known probands' clinical, molecular, and biochemical features and compared them, also to other metabolic forms of cutis laxa. We identified novel missense and the first nonsense variant strongly affecting ATP6V1A expression. All six ARCL2D affected individuals show equally severe cutis laxa and dysmorphism at birth. While for one no information was available, two died in infancy and three are now adolescents with mild or absent intellectual disability. Muscular weakness, ptosis, contractures, and elevated muscle enzymes indicated a persistent myopathy. In cellular studies, a fragmented Golgi compartment, a delayed Brefeldin A‐induced retrograde transport and glycosylation abnormalities were present in fibroblasts from two individuals. This is the second and confirmatory report on pathogenic variants in ATP6V1A as the cause of this extremely rare condition and the first to describe a nonsense allele. Our data highlight the tremendous clinical variability of ATP6V1A related phenotypes even within the same family.
Modernizing the Otolaryngology Referral Workflow: The Impact of Electronic Consultation
Authors: Kinberg Eliezer C. , Kirke Diana N. , Trosman Samuel J. 
Published: December 2020

Objectives/HypothesisTo determine the impact of electronic consultation on the otolaryngology clinic workflow at our high‐volume public hospital.Study DesignRetrospective Observational Study.MethodsThis is a retrospective observational analysis study. Operational data regarding clinic volume, referral patterns, and scheduling efficiency were assessed over a 9‐month period in 2018 prior to implementation of electronic consultation. The same data were collected for the 9‐month period immediately following implementation of electronic consultation in 2019.ResultsDuring the pre‐implementation (pre‐EC) period, 3,243 otolaryngology referrals were made as compared to 4,249 post‐implementation (post‐EC). 86% of referrals were scheduled for a clinic appointment pre‐EC, compared to 61% post‐EC (P < .00001) 24.5% of patients were evaluated within 30 days pre‐EC compared to 53.6% post‐EC (P < .00001). The average time to be seen by an otolaryngology provider declined from 60.8 days pre‐EC to 42.8 days post‐EC (P = .0029). There was a 50% decline in the percentage of appointments canceled by patients in the post‐EC period as compared to pre‐EC.ConclusionsIn our experience, implementation of electronic consultation significantly reduced both wait times for a clinic appointment and the percentage of no‐show or canceled appointments. Electronic consultation may be a valuable tool in improving the efficiency and yield of the modern otolaryngology clinic.Level of Evidence4 Laryngoscope, 131:E1792–E1796, 2021
A Prospective Study of Voice, Swallow, and Airway Outcomes Following Tracheostomy for COVID‐19
Authors: Rouhani Maral J. , Clunie Gemma , Thong Gerard , Lovell Lindsay , Roe Justin , Ashcroft Margaret , Holroyd Andrew , Sandhu Guri , Al Yaghchi Chadwan 
Published: December 2020

ObjectiveThe COVID‐19 pandemic has led to unprecedented demands on healthcare with many requiring intubation. Tracheostomy insertion has often been delayed and the enduring effects of this on voice, swallow, and airway outcomes in COVID‐19 tracheostomy patients are unknown. The aim of this study was to prospectively assess these outcomes in this patient cohort following hospital discharge.MethodsAll COVID‐19 patients who had undergone tracheostomy insertion, and were subsequently decannulated, were identified at our institution and followed up 2 months post‐discharge. Patient‐reported (PROMS) and clinician‐reported outcome measures, endoscopic examination, and spirometry were used to assess voice, swallow, and airway outcomes.ResultsForty‐one patients were included in the study with a mean age of 56 years and male:female ratio of 28:13. Average duration of endotracheal intubation was 24 days and 63.4% of tracheostomies were performed at day 21 to 35 of intubation. 53.7% had an abnormal GRBAS score and 30% reported abnormal swallow on EAT‐10 questionnaire. 81.1% had normal endoscopic examination of the larynx, however, positive endoscopic findings correlated with the patient self‐reported VHI‐10 (P = .036) and EAT‐10 scores (P = .027). 22.5% had spirometric evidence of fixed upper airway obstruction using the Expiratory‐Disproportion Index (EDI) and Spearman correlation analysis showed a positive trend between abnormal endoscopic findings and EDI scores over 50 (P < .0001).ConclusionThe preliminary results of this study reveal a high incidence of laryngeal injury among patients who underwent intubation and tracheostomy insertion during the COVID‐19 pandemic. As these patients continue to be followed up, the evolution of these complications will be studied.Level of Evidence3 Laryngoscope, 131:E1918–E1925, 2021
Virtual group consultations offer continuity of care globally during Covid‐19
Authors: Birrell Fraser , Lawson Rob , Sumego Marianne , Lewis Jessica , Harden Angela , Taveira Tracey , Stevens John , Manson Alison , Pepper Linda , Ickovics Jeannette 
Published: December 2020

AbstractCovid‐19 has led to virtual care (mainly telephone consultations) becoming a default worldwide, despite well‐documented shortcomings. Published evidence on virtual group consultations is limited, although interest and front‐line experience have grown substantially since pandemic onset. Unpublished data are summarised showing feasibility of transitioning care to this model across different countries, care settings and conditions. An international webinar series has supported development and sharing of best practice and representative data on spread and utilisation of virtual groups. This model of care creates time and space for more questions and answers, so once engaged patients become staunch advocates. Group care supports personalised care and lifestyle medicine, which is growing very rapidly. In the current context, even healthcare providers under pressure can implement virtual group consultations. Most virtual group consultations have a facilitator, so this allows roles to be extended and support education of both students and new team members. These can confer greater access, continuity of care, peer support and timely information about Covid‐19 and may result in better health outcomes. Given the rapid and widespread implementation of virtual care during this pandemic, data should be shared effectively and methodologically sound observational studies and clinical trials to test safety and effectiveness should be promoted now.
Benefits of matching consumers’ personality: Creating perceived trustworthiness via actual self‐congruence and perceived competence via ideal self‐congruence
Authors: Zogaj Adnan , Tscheulin Dieter K. , Olk Stephan 
Published: December 2020

AbstractEndorsers such as social media influencers who aim to match consumers’ personality to strengthen their credibility must consider that actual self‐congruence and ideal self‐congruence have different effects on the main dimensions of credibility: perceived trustworthiness and perceived competence. In our study, we conceptually argue that actual self‐congruence is associated more strongly with a closer psychological distance and, in turn, with trustworthy information, and we empirically show that perceived trustworthiness solely mediates the effect of actual self‐congruence on consumer behavior. Subsequently, we conceptually argue that ideal self‐congruence is more strongly related to ideal skills and therefore should be more strongly related to perceived competence, and we empirically demonstrate that perceived competence solely mediates the effect of ideal self‐congruence on consumer behavior. Our findings explain the mechanism behind the effects of actual and ideal self‐congruence and demonstrate important differences in authentic and aspirational marketing strategies with regard to creating the perception of trustworthiness and competence via social media influencers.
Genomic alterations in the F8 gene correlating with severe hemophilia A in Egyptian patients
Authors: Mosaad Rehab M. , Amr Khalda S. , Rabie Eman A. , Mostafa Naglaa O. , Habib Sonia A. , El‐Kamah Ghada Y. 
Published: December 2020

AbstractBackgroundHemophilia A (HA) is an inherited X‐linked recessive coagulation disorder caused by factor VIII (F8) deficiency. F8 rearrangements involving intron 22 (int22) and intron 1 (int1) account for almost half of severe HA phenotype also a hotspot exon 14 provides numerous mutational patterns. This study aims to identify F8 gene mutations among Egyptian HA patients.MethodsDNA samples from 60 HA patients were screened for int22 and int1 rearrangements using simplified inverse shifting PCR (IS‐PCR) followed by exon 14 sequencing. Also, four uncharacterized patients were studied by targeted exome sequencing.ResultsIn 33.3% of the studied patients, we identified three int22 rearrangements, three exon 14 mutations (two frameshift; one novel (NM_000132.3:c.2734_2735delAA, p.(N912Ffs*6)), a second reported mutation (NM_000132.3:c.3091_3094delAGAA, p.(K1031Lfs*9)), and one nonsense mutation (NM_000132.3:c.2440C>T, p.(R814*)). All identified mutations were detected in patients with severe HA phenotype. Targeted exome sequencing could not detect any known pathogenic variants.ConclusionIntron 22 rearrangement and exon 14 mutations correlate with most severe hemophilia A Egyptian patients.