bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observations of Upper-Tropospheric Temperature Inversions in the Indian Monsoon and Their Links to Convectively Forced Quasi-Stationary Kelvin Waves
Authors: Newton Richard , Randel William 
Published: July 2020

Abstract
High-vertical-resolution temperature measurements from GPS radio occultation data show frequent upper-tropospheric inversions over the equatorial Indian Ocean during the summer monsoon season. Each year, around 30% of profiles in this region have temperature inversions near 15 km during the monsoon season, peaking during July–September. This work describes the space–time behavior of these inversions, and their links to transient deep convection. The Indian Ocean inversions occur episodically several times each summer, with a time scale of 1–2 weeks, and are quasi stationary or slowly eastward moving. Strong inversions are characterized by cold anomalies in the upper-troposphere (12–15 km), warm anomalies in the tropopause layer (16–18 km), and strong zonal wind anomalies that are coherent with temperature anomalies. Temperature and wind anomalies are centered over the equator and show a characteristic eastward phase tilt with height with a vertical wavelength near 5 km, consistent with a Kelvin wave structure. Composites of outgoing longwave radiation (OLR) show that strong inversions are linked to enhanced deep convection over the equatorial Indian Ocean, preceding the inversions by ~2–6 days. These characteristics suggest that the inversions are linked to convectively forced Kelvin waves, which are Doppler shifted by the easterly monsoonal winds such that they remain quasi stationary in the equatorial Indian Ocean. These large-scale waves influence circulation on the equatorial side of the Indian monsoon anticyclone; they may provide a positive feedback to the underlying convection, and are possibly linked with regions of shear-induced turbulence.
An Internal Atmospheric Process Determining Summertime Arctic Sea Ice Melting in the Next Three Decades: Lessons Learned from Five Large Ensembles and Multiple CMIP5 Climate Simulations
Authors: Topál Dániel , Ding Qinghua , Mitchell Jonathan , Baxter Ian , Herein Mátyás , Haszpra Tímea , Luo Rui , Li Qingquan 
Published: July 2020

AbstractArctic sea ice melting processes in summer due to internal atmospheric variability have recently received considerable attention. A regional barotropic atmospheric process over Greenland and the Arctic Ocean in summer (June–August), featuring either a year-to-year change or a low-frequency trend toward geopotential height rise, has been identified as an essential contributor to September sea ice loss, in both observations and the CESM1 Large Ensemble (CESM-LE) of simulations. This local melting is further found to be sensitive to remote sea surface temperature (SST) variability in the east-central tropical Pacific Ocean. Here, we utilize five available large “initial condition” Earth system model ensembles and 31 CMIP5 models’ preindustrial control simulations to show that the same atmospheric process, resembling the observed one and the one found in the CESM-LE, also dominates internal sea ice variability in summer on interannual to interdecadal time scales in preindustrial, historical, and future scenarios, regardless of the modeling environment. However, all models exhibit limitations in replicating the magnitude of the observed local atmosphere–sea ice coupling and its sensitivity to remote tropical SST variability in the past four decades. These biases call for caution in the interpretation of existing models’ simulations and fresh thinking about models’ credibility in simulating interactions of sea ice variability with the Arctic and global climate systems. Further efforts toward identifying the causes of these model limitations may provide implications for alleviating the biases and improving interannual- and decadal-time-scale sea ice prediction and future sea ice projection.
A National Analysis of Traumatic Thoracic Aortic Repair: Does Insurance Status Matter?
Authors: Elkbuli Adel , Dowd Brianna , Narvel Raed Ismail , Smith Zachary , McKenney Mark , Boneva Dessy 
Published: July 2020

Background Traumatic thoracic aortic injuries (TAIs) carry a substantial mortality. Our study aim was to evaluate the impact of insurance status on outcomes in severely injured trauma patients after either thoracic endovascular aortic repair (TEVAR) or open repair using the National Trauma Data Bank Research Data Set (NTDB-RDS). Methods The NTDB-RDS was reviewed for outcomes in severely injured patients and TAI repair method (TEVAR vs open). Patients were divided into insured (Medicaid, Medicare, private insurance) and uninsured (self-pay) status groups. Patients were further divided by injury severity score (ISS) of 15-24 and ≥25 to adjust for injury burden. Demographic characteristics and outcome measures were compared. Chi-square, t-test, and analysis of variance were used with significance defined as P < .05. Results Within the NTDB-RDS, a review of nearly 1 million patients led to 241 that underwent repair for TAI and had insurance status and repair type documented. 88.8% (214/241) of patients were insured, while 11.2% (27/241) of patients were uninsured. There were no significant differences in repair type based on insurance status. For open repair with an ISS ≥25, mortality was significantly higher in the uninsured group compared with insured (55.5% vs 21.9%, P = .001). Conclusion For open repair in patients with TAI and high injury burden, uninsured status was associated with a significant increase in mortality rate compared with insured patients. Future studies should investigate the effect of insurance type on TAI outcomes and causes of higher mortality in uninsured patients.
Social capital and mental health problems among Syrian refugee adolescents: The mediating roles of perceived social support and post-traumatic symptoms
Authors: Duren Rahşan , Yalçın Özgen 
Published: July 2020

Background: Social capital is one of the prominent components of refugee mental health. However, its role on mental health is poorly understood. Aims: The aim of the present study was to investigate the nature of the association between social capital and mental health problems in refugee adolescents. Method: A cross-sectional study with three hundred twenty-one 12- to 18-year-old Syrian refugee adolescents was conducted in Turkey. We administered the Arabic versions of the following instruments in school settings: The Social Trust, Multidimensional Scale of Perceived Social Support (MSPSS), The Children’s Impact of Event Scale (CRIES-8) and The Strengths and Difficulties Questionnaire (SDQ). Results: The mediation analyses with Hayes’ PROCESS Macro revealed that perceived social support and the intensity of post-traumatic stress disorder (PTSD) symptoms fully mediated the relationship between social capital and mental health problems. Conclusion: The results suggested social trust’s two distinct functions which impair the likelihood of mental health problems: (a) social trust might help to facilitate perceived social support from family and friends and (b) social trust might impair the intensity of traumatic experiences.
Confronting Empires: Manhae's Understanding of Buddhism
Authors: Woosung Huh 
Published: July 2020

AbstractThis paper outlines some key ideas of the twentieth-century Buddhist monk Han Yong-un, or Manhae. It focuses in particular on Manhae's social engagement under the Japanese occupation. It underlines the role played by Manhae's doctrine in reviving a national sentiment and culture in Korea. It elaborates on his doctrine of the Loved one, or nim, sketches the mutual influences of Buddhism and Confucianism in his thought, and builds on his critique of imperialism, militarism, and Korean “self-ruination.”
A Case of Successful Allogeneic Hematopoietic Stem Cell Transplantation for HHV8-Positive Castleman’s Disease with a Review of the Literature
Authors: Wang Zhen , Yang Shiwei , Zhu Zunmin , Lei Pingchong , Yang Jing , Zhang Ping , Sun Kai 
Published: July 2020

Objective: To investigate the long-term clinical efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with human herpes virus 8 (HHV8)-positive multicentric Castleman’s disease (MCD). Methods: A 17-year-old female patient was admitted to Henan Provincial People’s Hospital with the complaint of febrile for half a month, headache, and enlarged superficial lymph nodes on October 5, 2010. HHV8-positive mixed cellular Castleman’s disease was found by pathological diagnosis of lymph nodes biopsy. After the administration of CHOP and Hyper-CVAD-B, the patient was still febrile, we administrated the followed COAP, two courses of VAD(Vincristine, Adriamycin, Dexamethasone), the patient received CR. Six months after CR, the patient relapsed, we administrated VAD and two courses of bortezomide+dexamethasone chemotherapy, and then the patient received PR. After that, the patient underwent allo-HSCT from his human leukocyte antigen (HLA)-matched unrelated donor after conditioning with Bu/Cy+Etoposide+Smoustin.graft-vs-host disease (GVHD) prophylaxis, which consisted of ATG (7.5 mg/kg, qd, ivdrip) from d-5 to d-2, cyclosporine (3 mg/kg/d, qd, ivdrip, for 24 h) started from day-1, MMF(0.5 g, tid, po.) started from day+1 to +28, and MTX (15 mg per time, ivdrip, d+1,+4,+7,+11). She received 3.5×106/L CD34+cells and 8.1×108/LMNC. Results: Granulocyte engraftment occurred on day+12, platelet engrafted on day+14. Bone marrow biopsy showed normalization of trilineage hematopoiesis on day+33, chimerism: 97.6%. The transplantation was successful and followed up for 7 years with CR. Conclusion: Allo-HSCT might cure patients with refractory/relapsed HHV8+ MCD.
Distribution, Stability, and Continuity of Autonomic Nervous System Responsivity at 18- and 36-Months of Age
Authors: Stephens Michelle , Bush Nicole , Weiss Sandra , Alkon Abbey 
Published: July 2020

Objective: Cardiac autonomic nervous system (ANS) measures, respiratory sinus arrhythmia (RSA) and preejection period (PEP), are valid and reliable indicators of children’s sensitivity to their environment; however, there are few studies of ANS measures in children less than three years of age. This study’s aim was to summarize the distributions, stability, and continuity of RSA and PEP measures during resting, challenge, and reactivity for children at 18- and 36-months. Methods: This was a cohort study of racially- and ethnically-diverse, low-income children who completed a developmentally challenging protocol while we simultaneously assessed their RSA and PEP at 18-months (N = 134) and 36-months (N = 102). Results: The ANS resting, challenge, and reactivity measures at 18- and 36-months of age were normally distributed. The RSA resting (r = 0.29), RSA challenge (r = 0.44), PEP resting (r = 0.55) and PEP challenge (r = 0.58) measures were moderately stable but RSA (r = 0.01) and PEP reactivity (r = 0.02) were not stable from 18- to 36-months of age. There was no continuity in the ANS measures from 18- to 36-months of age with statistically significant changes in sample means for all of the ANS measures. Discussion: These developmental changes in ANS are shown at the sample level but there are individual differences in ANS responses from 18- to 36-months that may be affected by adversity or protective factors experienced early in life.
Are Republicans Bad for the Environment?
Authors: Fowler Luke , Kettler Jaclyn J. 
Published: July 2020

AbstractDoes the partisanship of officeholders affect environmental outcomes? The popular perception is that Republicans are bad for the environment, but complicating factors like federalism may limit this outcome. Using a dataset that tracks toxic releases over 20 years, we examine how partisan control of executive and legislative branches at both state and federal levels affect environmental policy. Moving beyond the passage of policies or environmental program spending allows us to fully understand the impact of Republicans on the environment. In addition, we take into account structural complications that may shape the relationship between Republican control and environmental outcomes. We find that the conventional wisdom that Republicans are bad for the environment has some validity, but it is dependent on what offices Republican elected officials occupy. More specifically, Republicans significantly affect toxic chemical releases when occupying governorships and controlling Congress. Our conclusions provide further insight into understanding how partisanship affects environmental outcomes, including how partisanship composition across the federal system matters.
Determinants of low birth weight among live birth newborns delivered at public hospitals in Gamo Gofa Zone, South Ethiopia: Unmatched case control study
Authors: Mingude Alemu Basazin , Gebretsadik Woiynshet , Misker Dresilgn , Woldeamanuel Gashaw Garedew 
Published: July 2020

Background: Birth weight is one of the major determinants of perinatal survival, infant morbidity, and mortality. There are only few published reports on assessment of low birth weight in Ethiopia and the determinants of low birth weight have not been well characterized. Objective: The aim of this study was to assess determinants of low birth weight among live birth newborns delivered at public hospitals in Gamo Gofa Zone, South Ethiopia. Methods: Institution-based case control study was conducted from February 25 to April 25, 2018 and consecutively selected 60 cases and 240 controls were enrolled in this study. The data were collected using face-to-face interview and review of medical records. Moreover, we have measured the newborns’ birth weight using a standard weight scale and mother’s mid-upper arm circumference using a standard World Health Organization mid-upper arm circumference measuring tape. Statistical analysis of the data was done using SPSS version 21. Results: A total of 300 newborns were included in the study. Late antenatal care booking (adjusted odds ratio = 1.87, confidence interval = [1.32–2.6]), birth interval <2 years (adjusted odds ratio = 0.385, confidence interval = [0.176–0.83]), anemia (adjusted odds ratio = 4.4, confidence interval = [1.84–10.5]), mid-upper arm circumference <23 cm (adjusted odds ratio = 7.99, confidence interval = [3.5–20.3]), nutritional counseling (adjusted odds ratio = 5.85, confidence interval = [2.14–14.8]), and husband smoking (adjusted odds ratio = 4.73; confidence interval = [1.42–15.7]) were found to be determinant factors of low birth weight. Conclusion: Most of the determining factors of low birth weight were preventable. Therefore, clinical and public health interventions should target on those determinant factors to prevent its adverse effects.
Natromarkeyite and pseudomarkeyite, two new calcium uranyl carbonate minerals from the Markey mine, San Juan County, Utah, USA
Authors: Kampf Anthony R. , Olds Travis A. , Plášil Jakub , Burns Peter C. , Marty Joe 
Published: July 2020

AbstractThe new minerals natromarkeyite, Na2Ca8(UO2)4(CO3)13(H2O)24⋅3H2O (IMA2018-152) and pseudomarkeyite, Ca8(UO2)4(CO3)12(H2O)18⋅3H2O (IMA2018-114) were found in the Markey mine, San Juan County, Utah, USA, where they occur as secondary phases on asphaltum. Natromarkeyite properties are: untwinned blades and tablets to 0.2 mm, pale yellow green colour; transparent; white streak; bright bluish white fluorescence (405 nm laser); vitreous to pearly lustre; brittle; Mohs hardness 1½ to 2; irregular fracture; three cleavages ({001} perfect, {100} and {010} good); density = 2.70(2) g cm–3; biaxial (–) with α = 1.528(2), β = 1.532(2) and γ = 1.533(2); and pleochroism is X = pale green yellow, Y ≈ Z = light green yellow. Pseudomarkeyite properties are: twinned tapering blades and tablets to 1 mm; pale green yellow colour; transparent; white streak; bright bluish white fluorescence (405 nm laser); vitreous to pearly lustre; brittle; Mohs hardness ≈ 1; stepped fracture; three cleavages ({10$\bar{1}$} very easy, {010} good, {100} fair); density = 2.88(2) g cm–3; biaxial (–) with α = 1.549(2), β = 1.553(2) and γ = 1.557(2); and it is nonpleochroic. The Raman spectra of markeyite, natromarkeyite and pseudomarkeyite are very similar and exhibit bands consistent with UO22+, CO32– and O–H. Electron microprobe analyses provided the empirical formula Na2.01Ca7.97Mg0.03Cu2+0.05(UO2)4(CO3)13(H2O)24⋅3H2O (–0.11 H) for natromarkeyite and Ca7.95(UO2)4(CO3)12(H2O)18⋅3H2O (+0.10 H) for pseudomarkeyite. Natromarkeyite is orthorhombic, Pmmn, a = 17.8820(13), b = 18.3030(4), c = 10.2249(3) Å, V = 3336.6(3) Å3 and Z = 2. Pseudomarkeyite is monoclinic, P21/m, a = 17.531(3), b = 18.555(3), c = 9.130(3) Å, β = 103.95(3)°, V = 2882.3(13) Å3 and Z = 2. The structures of natromarkeyite (R1 = 0.0202 for 2898 I > 2σI) and pseudomarkeyite (R1 = 0.0787 for 2106 I > 2σI) contain uranyl tricarbonate clusters that are linked by (Ca/Na)–O polyhedra forming thick corrugated heteropolyhedral layers. Natromarkeyite is isostructural with markeyite; pseudomarkeyite has a very similar structure.
Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
Authors: Basar Rafet , Daher May , Uprety Nadima , Gokdemir Elif , Alsuliman Abdullah , Ensley Emily , Ozcan Gonca , Mendt Mayela , Hernandez Sanabria Mayra , Kerbauy Lucila Nassif , Nunez Cortes Ana Karen , Li Li , Banerjee Pinaki P. , Muniz-Feliciano Luis , Acharya Sunil , Fowlkes Natalie W. , Lu Junjun , Li Sufang , Mielke Stephan , Kaplan Mecit , Nandivada Vandana , Bdaiwi Mustafa , Kontoyiannis Alexander D. , Li Ye , Liu Enli , Ang Sonny , Marin David , Brunetti Lorenzo , Gundry Michael C. , Turk Rolf , Schubert Mollie S. , Rettig Garrett R. , McNeill Matthew S. , Kurgan Gavin , Behlke Mark A. , Champlin Richard , Shpall Elizabeth J. , Rezvani Katayoun 
Published: July 2020

Abstract
Virus-specific T cells have proven highly effective for the treatment of severe and drug-refractory infections after hematopoietic stem cell transplant (HSCT). However, the efficacy of these cells is hindered by the use of glucocorticoids, often given to patients for the management of complications such as graft-versus-host disease. To address this limitation, we have developed a novel strategy for the rapid generation of good manufacturing practice (GMP)–grade glucocorticoid-resistant multivirus-specific T cells (VSTs) using clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) gene-editing technology. We have shown that deleting the nuclear receptor subfamily 3 group C member 1 (NR3C1; the gene encoding for the glucocorticoid receptor) renders VSTs resistant to the lymphocytotoxic effect of glucocorticoids. NR3C1-knockout (KO) VSTs kill their targets and proliferate successfully in the presence of high doses of dexamethasone both in vitro and in vivo. Moreover, we developed a protocol for the rapid generation of GMP-grade NR3C1 KO VSTs with high on-target activity and minimal off-target editing. These genetically engineered VSTs promise to be a novel approach for the treatment of patients with life-threatening viral infections post-HSCT on glucocorticoid therapy.
Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET
Authors: Alter Peter , Orszag Jan , Kellerer Christina , Kahnert Kathrin , Speicher Tim , Watz Henrik , Bals Robert , Welte Tobias , Vogelmeier Claus F. , Jörres Rudolf A. 
Published: July 2020

BackgroundAir trapping and lung hyperinflation are major determinants of prognosis and response to therapy in chronic obstructive pulmonary disease (COPD). They are often determined by body plethysmography, which has limited availability, and so the question arises as to what extent they can be estimatedviaspirometry.MethodsWe used data from visits 1–5 of the COPD cohort COSYCONET. Predictive parameters were derived from visit 1 data, while visit 2–5 data was used to assess reproducibility. Pooled data then yielded prediction models including sex, age, height, and body mass index as covariates. Hyperinflation was defined as ratio of residual volume (RV) to total lung capacity (TLC) above the upper limit of normal. (ClinicalTrials.gov identifier:NCT01245933).ResultsVisit 1 data from 1988 patients (Global Initiative for Chronic Obstructive Lung Disease grades 1–4, n=187, 847, 766, 188, respectively) were available for analysis (n=1231 males, 757 females; mean±sdage 65.1±8.4 years; forced expiratory volume in 1 s (FEV1) 53.1±18.4 % predicted (% pred); forced vital capacity (FVC) 78.8±18.8 % pred; RV/TLC 0.547±0.107). In total, 7157 datasets were analysed. Among measures of hyperinflation, RV/TLC showed the closest relationship to FEV1% pred and FVC % pred, which were sufficient for prediction. Their relationship to RV/TLC could be depicted in nomograms. Even when neglecting covariates, hyperinflation was predicted by FEV1% pred, FVC % pred or their combination with an area under the curve of 0.870, 0.864 and 0.889, respectively.ConclusionsThe degree of air trapping/hyperinflation in terms of RV/TLC can be estimated in a simple manner from forced spirometry, with an accuracy sufficient for inferring the presence of hyperinflation. This may be useful for clinical settings, where body plethysmography is not available.
Transbronchial cryobiopsy: an effective tool in the diagnosis of lymphoproliferative disorders of the lung
Authors: Bianchi Rita , Dubini Alessandra , Asioli Silvia , Ravaglia Claudia , Tomassetti Sara , Puglisi Silvia , Piciucchi Sara , Gurioli Christian , Gurioli Carlo , Fiocca Roberto , Poletti Venerino 
Published: July 2020

IntroductionMalignant lymphoproliferative disorders are rarely observed in the lung and, considering their clinical and radiological heterogeneity, diagnosis is often difficult and may require invasive methods. Transbronchial cryobiopsy has been confirmed as a new tool in the diagnosis of interstitial lung diseases, given its fewer risks and costs compared to surgical approach. This study is aimed at assessing the effectiveness of cryobiopsy in the diagnosis of lymphoproliferative disorders.Materials and methodsAmong 970 consecutive cryobiopsies, performed between January 2011 and June 2018 at Morgagni Hospital of Forlì, Italy, 13 cases of lymphoproliferative disorders were collected.ResultsIn 12 out of 13 cases a precise pathological diagnosis could be reached with the support of immunohistochemistry (IHC) and molecular ancillary studies. In the only case in which cryobiopsy did not lead to a definitive diagnosis, the subsequent surgical biopsy also did not help to clarify the diagnosis. Severe bleeding or pneumothorax did not occur in any case. On average, five biopsies were obtained per case, with a mean total area of 1161 mm2, and only 5 out of 65 specimens were inadequate for diagnosis. Instant freezing did not produce tissue artefacts nor did it affect IHC and molecular tests. In all cases the amount of available tissue was sufficient for all ancillary studies.ConclusionsTransbronchial lung cryobiopsy is safe and effective for diagnosis in patients with suspected pulmonary involvement by lymphoproliferative disorders and it should therefore be considered a valid alternative to surgical biopsy in such cases.