bluuebunny/crossref_metadata_2025_split huggingface dataset:
The magnetic field and accretion regime of CI Tau
Authors: Donati J-F , Bouvier J , Alencar S H , Moutou C , Malo L , Takami M , Ménard F , Dougados C , Hussain G A ,   the MaTYSSE collaboration
Published: December 2019

ABSTRACT
This paper exploits spectropolarimetric data of the classical T Tauri star CI Tau collected with ESPaDOnS at the Canada–France–Hawaii Telescope, with the aims of detecting and characterizing the large-scale magnetic field that the star hosts, and of investigating how the star interacts with the inner regions of its accretion disc through this field. Our data unambiguously show that CI Tau has a rotation period of 9.0 d, and that it hosts a strong, mainly poloidal large-scale field. Accretion at the surface of the star concentrates within a bright high-latitude chromospheric region that spatially overlaps with a large dark photospheric spot, in which the radial magnetic field reaches −3.7 kG. With a polar strength of −1.7 kG, the dipole component of the large-scale field is able to evacuate the central regions of the disc up to about 50 per cent of the co-rotation radius (at which the Keplerian orbital period equals the stellar rotation period) throughout our observations, during which the average accretion rate was found to be unusually high. We speculate that the magnetic field of CI Tau is strong enough to sustain most of the time a magnetospheric gap extending to at least 70 per cent of the co-rotation radius, which would explain why the rotation period of CI Tau is as long as 9 d. Our results also imply that the 9 d radial velocity (RV) modulation that CI Tau exhibits is attributable to stellar activity, and thus that the existence of the candidate close-in massive planet CI Tau b to which these RV fluctuations were first attributed needs to be reassessed with new evidence.
Short- and long-term near-infrared spectroscopic variability of eruptive protostars from VVV
Authors: Guo (郭震) Zhen , Lucas P W , Contreras Peña C , Kurtev R G , Smith L C , Borissova J , Alonso-García J , Minniti D , Caratti o Garatti A , Froebrich D 
Published: December 2019

ABSTRACT
Numerous eruptive variable young stellar objects (YSOs), mostly Class I systems, were recently detected by the near-infrared Vista Variables in the Via Lactea (VVV) survey. We present an exploratory near-infrared spectroscopic variability study of 14 eruptive YSOs. The variations were sampled over one-day and one-to-two-year intervals and analysed in combination with VVV light curves. CO overtone absorption features are observed on three objects with FUor-like spectra: all show deeper absorption when they are brighter. This implies stronger emission from the circumstellar disc with a steeper vertical temperature gradient when the accretion rate is higher. This confirms the nature of fast VVV FUor-like events, in line with the accepted picture for classical FUors. The absence of Brγ emission in a FUor-like object declining to pre-outburst brightness suggests that reconstruction of the stellar magnetic field is a slow process. Within the one-day time-scale, 60 per cent of H2-emitting YSOs show significant but modest variation, and 2/6 sources have large variations in Brγ. Over year-long time-scales, H2 flux variations remain modest despite up to 1.8 mag variation in Ks. This indicates that emission from the molecular outflow usually arises further from the protostar and is unaffected by relatively large changes in accretion rate on year-long time-scales. Two objects show signs of on/off magnetospheric accretion traced by Brγ emission. In addition, a 60 per cent inter-night brightening of the H2 outflow is detected in one YSO.
Free energy landscape of salt-actuated reconfigurable DNA nanodevices
Authors: Shi Ze , Arya Gaurav 
Published: December 2019

Abstract
Achieving rapid, noninvasive actuation of DNA structures is critical to expanding the functionality of DNA nanotechnology. A promising actuation approach involves introducing multiple, short pairs of single-stranded DNA overhangs to components of the structure and triggering hybridization or dissociation of the overhangs via changes in solution ionic conditions to drive structural transitions. Here, we reveal the underlying basis of this new approach by computing via molecular simulations the free energy landscape of DNA origami hinges actuated between open and closed states. Our results reveal how the overhangs collectively introduce a sharp free-energy minimum at the closed state and a broad energy barrier between open and closed states and how changes in ionic conditions modulate these features of the landscape to drive actuation towards the open or closed state. We demonstrate the critical role played by hinge confinement in stabilizing the hybridized state of the overhangs and magnifying the energy barrier to dissociation. By analyzing how the distribution of overhangs and their length and sequence modulate the energy landscape, we obtain design rules for tuning the actuation behavior. The molecular insights obtained here should be applicable to a broad range of systems involving DNA hybridization within confined systems.
Sodium-glucose cotransporter 2 inhibition: which patient with chronic kidney disease should be treated in the future?
Authors: Neuen Brendon L , Jardine Meg J , Perkovic Vlado 
Published: November 2019

Abstract
The advent of sodium-glucose cotransporter 2 (SGLT2) inhibitors represents a major advance for people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). The results of the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial have clearly demonstrated that canagliflozin prevents kidney failure and cardiovascular events. The results from three other large-scale randomized trials, collectively enrolling &gt;30 000 participants, have provided further evidence that the effects of SGLT2 inhibition on major kidney outcomes in people with T2DM may be present across the class, although this will only be known for certain when Dapagliflozin and Renal Outcomes and Cardiovascular Mortality in Patients with CKD (DAPA-CKD) (NCT03036150) and The Study of Heart and Kidney Protection with Empagliflozin (EMPA-KIDNEY) (NCT03594110) are reported over coming years. Importantly, the benefits of SGLT2 inhibition have been achieved in addition to the current standard of care. This review summarizes evidence for SGLT2 inhibition in people with T2DM and CKD, evaluates key patient characteristics and concomitant drug use that may influence the use of these drugs in people with CKD, discusses current guideline recommendations and explores how these drugs may be used in people with CKD in the future, including in combination with other treatments.
The Association Between Smoking and Gut Microbiome in Bangladesh
Authors: Nolan-Kenney Rachel , Wu Fen , Hu Jiyuan , Yang Liying , Kelly Dervla , Li Huilin , Jasmine Farzana , Kibriya Muhammad G , Parvez Faruque , Shaheen Ishrat , Sarwar Golam , Ahmed Alauddin , Eunus Mahbub , Islam Tariqul , Pei Zhiheng , Ahsan Habibul , Chen Yu 
Published: December 2019

AbstractIntroductionEpidemiological studies that investigate alterations in the gut microbial composition associated with smoking are lacking. This study examined the composition of the gut microbiome in smokers compared with nonsmokers.Aims and MethodsStool samples were collected in a cross-sectional study of 249 participants selected from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Microbial DNA was extracted from the fecal samples and sequenced by 16S rRNA gene sequencing. The associations of smoking status and intensity of smoking with the relative abundance or the absence and presence of individual bacterial taxon from phylum to genus levels were examined.ResultsThe relative abundance of bacterial taxa along the Erysipelotrichi-to-Catenibacterium lineage was significantly higher in current smokers compared to never-smokers. The odds ratio comparing the mean relative abundance in current smokers with that in never-smokers was 1.91 (95% confidence interval = 1.36–2.69) for the genus Catenibacterium and 1.89 (95% confidence interval = 1.39–2.56) for the family Erysipelotrichaceae, the order Erysipelotrichale, and the class Erysipelotrichi (false discovery rate-adjusted p values = .0008–.01). A dose–response association was observed for each of these bacterial taxa. The presence of Alphaproteobacteria was significantly greater comparing current with never-smokers (odds ratio = 4.85, false discovery rate-adjusted p values = .04).ConclusionsOur data in a Bangladeshi population are consistent with evidence of an association between smoking status and dosage with change in the gut bacterial composition.ImplicationsThis study for the first time examined the relationship between smoking and the gut microbiome composition. The data suggest that smoking status may play an important role in the composition of the gut microbiome, especially among individuals with higher levels of tobacco exposure.
Support for E-cigarette and Tobacco Control Policies Among Parents of Adolescents
Authors: Czaplicki Lauren , Perks Siobhan N , Liu Michael , Cuccia Alison , Patel Minal , Vallone Donna , Schillo Barbara 
Published: December 2019

Abstract

Introduction
Parents are essential stakeholders for policy implementation. However, data on parents’ support for e-cigarette- and tobacco-related policies is limited. This study examines parents’ support for five e-cigarette- and tobacco-related policies targeted to prevent youth initiation and exposure to industry marketing practices.

Methods
Data were from a 2018 nationally representative sample of US parents of 11- to 18-year-old middle and high school students. Weighted adjusted logistic regression models examined correlates of support for policy outcomes, controlling for demographics. Analyses were performed among the full sample (n = 2743) and among current tobacco users (n = 355).

Results
The majority of parents, including current tobacco users, supported tobacco control efforts to protect adolescents. More than 90% of all parents supported restrictions on e-cigarette marketing to youth and 75% supported a ban on flavored e-cigarette sales. Additionally, more than 80% of all parents supported increasing the age of tobacco product sale to 21, limiting tobacco retailer density near schools, and keeping tobacco products out of view where youth shop. Presence of strict home tobacco rules or reporting a high priority to prevent child’s e-cigarette use were significantly associated with higher odds of policy support. Results were similar among current tobacco users.

Conclusions
Parents are an important group of tobacco control stakeholders and should be utilized to garner support for tobacco control policies in the context of the recent growth in youth tobacco and e-cigarette use. Parents’ public support for tobacco control policies, particularly regulations on e-cigarette sales and marketing, can motivate advocates and policymakers to advance tobacco control policy agendas.

Implications
Youth tobacco and e-cigarette use in the United States has increased in recent years. Parents are important stakeholders to inform policy agendas and advance efforts to restrict youth access and exposure to tobacco products. This study provides evidence that parents of adolescents are highly supportive of youth-centered tobacco control policies, particularly those that restrict access to youth-targeted e-cigarette marketing and the sale of youth-appealing flavored e-cigarettes. Utilizing policy support to mobilize parents may be an important advocacy strategy to advance tobacco control policy agendas and curb rising rates of youth e-cigarette and tobacco use.
Association between physical activity and sickness absenteeism in university workers
Authors: López-Bueno R , Smith L , Andersen L L , López-Sánchez G F , Casajús J A 
Published: December 2019

Abstract

Background
Sedentary occupations have increased by more than 10% in Western countries over the last two decades, and the yearly global cost of physical inactivity has been estimated to be $53.8 billion. As workers tend to move less in the workplace, they are more likely to develop a sedentarism-related chronic condition and to be absent from work due to illness, although research evidence on the issue remains unclear.

Aims
To investigate associations between physical activity (PA) and sickness absenteeism in the workplace among Spanish university workers.

Methods
We conducted cross-sectional research with data from 1025 workers aged 18–65 years (43% women) from a Spanish university. Physical Activity Vital Sign (PAVS) and International Physical Activity Questionnaire (IPAQ) short versions were used to evaluate levels of PA. Workplace absenteeism was self-reported by participants. Written questionnaires distributed during medical checks included PAVS, IPAQ and the question about absenteeism among other information. The association between PA and sickness absenteeism was examined using adjusted multiple linear regression.

Results
After adjusting for age, sex, job function, chronic conditions, sedentarism and smoking, each weekly hour of PA reduced sickness absence by −1.20 (95% confidence interval: −2.40–0.00) days per year.

Conclusions
The implementation of PA promotion strategies aimed at university employees may lead to a reduction of days off work due to illness.
An unusual cause of lacunar infarcts: Lambl’s excrescences on aortic valve shown in detail by 3D transesophageal echocardiography
Authors: Çöllüoğlu Tuğçe , Önalan Orhan 
Published: November 2019

Abstract
Lambl’s excrescences (LE) are rare cardiac structures. They are associated with catastrophic thromboembolic and coronary events. Despite resulting in such important events, 2D echocardiographic imaging modalities may overlook LE owing to very thin cardiac structures. So, 3D echocardiographic imaging modalities may fully offer this cardiac mass and provide us to more accurately guess the complication rate related to LE due to the fact that 3D echocardiographic imaging techniques have higher spatial resolution and are not based on the geometric assumption. Indeed, another benefit of 3D echocardiographic imaging modalities in this population is that these imaging modalities clearly provide the relationship to adjacent structures of LE and its movement over a cardiac cycle in 3D space. In our case report, we aim to present the usefulness of 3D echocardiography as a modality to clearly offer all features of LE, furthermore to give valuable information about management in patients with thromboembolic events leading to LE.
A case of tracheal pleomorphic adenoma misdiagnosed as asthma
Authors: Takahashi Mamoru , Yorozuya Takahumi , Miyasaka Yuki , Kodama Kentaro , Yoshikawa Takumi , Taya Tetsuya , Mori Yuki , Ikeda Kimiyuki , Miyajima Satsuki , Chiba Hirofumi , Takahashi Hiroki 
Published: November 2019

Abstract
A 51-year-old woman had an incidental finding of a tracheal tumor during oesophagogastroduodenoscopy following the diagnosis of asthma for 2 months. A computed tomography scan revealed a 15-mm tumor in the subglottis. Endoscopic resection was performed safely, and pleomorphic adenoma was diagnosed histologically. The patient’s condition was satisfactory 30 months after the procedure. Tracheal pleomorphic adenoma is rare and may be misdiagnosed as asthma. If the tumor is large, surgery may be required; however, endoscopic polypectomy may be effective if the tumor is small. Therefore, early diagnosis of tracheal pleomorphic adenoma is important. At the first visit, the flow–volume curve suggested upper airway obstruction, which should have raised the suspicion of an upper airway obstruction. In patients with suspected asthma, early pulmonary function testing is needed to substantiate asthma diagnosis and prevent an alternative diagnosis being missed.
Addition of Slowly Repeated Evoked Pain Responses to Clinical Symptoms Enhances Fibromyalgia Diagnostic Accuracy
Authors: de la Coba Pablo , Bruehl Stephen , del Paso Gustavo A. Reyes 
Published: December 2019

Abstract

Objective
Fibromyalgia is a chronic pain syndrome characterized by central sensitization. A novel protocol based on slowly repeated evoked pain (SREP) appears to be a useful marker of pain sensitization in fibromyalgia patients. Whether SREP enhances diagnostic accuracy beyond key clinical symptoms that characterize fibromyalgia has not been examined.

Methods
Fifty fibromyalgia patients, 30 rheumatoid arthritis patients, and 50 healthy individuals were evaluated to assess clinical pain, as well as fatigue, insomnia, pain catastrophizing, and negative mood. The SREP protocol consisted of a series of nine low-intensity painful pressure stimuli of five seconds’ duration with 30-second interstimulus intervals. SREP sensitization was indexed by increases in pain intensity ratings across stimuli.

Results
SREP sensitization was observed in fibromyalgia but not in rheumatoid arthritis or healthy individuals. As expected, fibromyalgia patients exhibited a more negative psychosocial profile than did rheumatoid arthritis patients and healthy individuals. SREP was positively associated with clinical pain, fatigue, insomnia, and catastrophizing, but not with negative mood. SREP discriminated fibromyalgia cases from rheumatoid arthritis and healthy individuals even when current clinical pain was included in the analysis. Combining fatigue, insomnia, and SREP led to near perfect diagnostic accuracy (99%) in differentiating fibromyalgia from healthy individuals and 86.3% accuracy in discriminating fibromyalgia from rheumatoid arthritis.

Conclusions
These results provide further evidence of SREP as a marker of pain sensitization in fibromyalgia and suggest that it captures aspects of fibromyalgia not fully captured by clinical features. Combining SREP with assessment of clinical features could potentially improve fibromyalgia diagnosis.
Behçet: the syndrome
Authors: Bettiol Alessandra , Prisco Domenico , Emmi Giacomo 
Published: December 2019

AbstractBehçet’s syndrome (BS) is a systemic vasculitis characterized by a relapsing and remitting course. It can involve the skin, mucosa, joints, vessels (arteries and/or veins), eyes, and nervous and gastrointestinal systems, and so is referred to as a syndrome rather than as a unique and nosologically distinct condition. These involvements may present alone or co-exist in the same patient. Although all the possible combinations of the above-mentioned manifestations may occur, clusters of commonly co-existing involvements (also referred to as ‘disease phenotypes’) have been suggested, namely ‘mucocutaneous and articular’, ‘peripheral vascular and extra-parenchymal neurological’ and ‘parenchymal neurological and ocular’ phenotypes have been described. Patient-specific demographic and genetic features have been described as positively or negatively associated with specific disease phenotypes. This review will focus on the different clinical features of Behçet’s syndrome, summarizing current evidence on the distinct disease manifestations as well as the major phenotypes.
Selection for bull fertility: a review
Authors: Butler Madison L , Bormann Jennifer M , Weaber Robert L , Grieger David M , Rolf Megan M 
Published: December 2019

Abstract
Fertility is a critically important factor in cattle production because it directly relates to the ability to produce the offspring necessary to offset costs in production systems. Female fertility has received much attention and has been enhanced through assisted reproductive technologies, as well as genetic selection; however, improving bull fertility has been largely ignored. Improvements in bull reproductive performance are necessary to optimize the efficiency of cattle production. Selection and management to improve bull fertility not only have the potential to increase conception rates but also have the capacity to improve other economically relevant production traits. Bull fertility has reportedly been genetically correlated with traits such as average daily gain, heifer pregnancy, and calving interval. Published studies show that bull fertility traits are low to moderately heritable, indicating that improvements in bull fertility can be realized through selection. Although female fertility has continued to progress according to increasing conception rates, the reported correlation between male and female fertility is low, indicating that male fertility cannot be improved by selection for female fertility. Correlations between several bull fertility traits, such as concentration, number of spermatozoa, motility, and number of spermatozoa abnormalities, vary among studies. Using male fertility traits in selection indices would provide producers with more advanced selection tools. The objective of this review was to discuss current beef bull fertility measurements and to discuss the future of genetic evaluation of beef bull fertility and potential genetic improvement strategies.
Mathematics educators are speaking about PISA, aren’t they?
Authors: Giberti Chiara , Maffia Andrea 
Published: December 2019

AbstractThis paper sets out to explore the different uses made of Organisation for Economic Co-operation and Development Program for International Student Assessment (OECD-PISA) tests and data in mathematics education research. Through a comprehensive literature review of journals and conference papers, we show that although a large variety of topics is addressed, they do not cover all the topics considered in mathematics education research. Analysing the temporal and geographical distribution of papers, we find that there is increasing interest in the use of PISA in our field of research and that different countries are involved in different ways in mathematics education research about PISA. As a conclusion, we suggest that critical research into the effect of PISA can be developed further, especially in those countries that have joined the OECD survey in recent years. Other future research paths using data from PISA are detected.
Phylogeny, taxonomy and distribution of the Neotropical lizard genus Echinosaura (Squamata: Gymnophthalmidae), with the recognition of two new genera in Cercosaurinae
Authors: Vásquez-Restrepo Juan D , Ibáñez Roberto , Sánchez-Pacheco Santiago J , Daza Juan M 
Published: December 2019

AbstractThe family Gymnophthalmidae is a highly diverse Neotropical lizard clade. Although multiple phylogenetic and taxonomic studies have reshaped our understanding of gymnophthalmid systematics and diversity, many groups remain understudied. This is the case for the cercosaurine genus Echinosaura, which includes eight species of small riparian lizards distributed across lower Central America and northern South America. Here, we present a comprehensive phylogenetic analysis of Echinosaura, including DNA data for all species of the genus for the first time. To rigorously test the relationships of all Echinosaura, we have assembled the largest molecular dataset of cercosaurine lizards to date. Our analysis refutes the monophyly of Echinosaura, with E. apodema and E. sulcarostrum not closely related to the remaining species. To remedy the polyphyly of Echinosaura, we describe two new genera for E. apodema and E. sulcarostrum. Morphological distinctiveness and biogeography further support these taxonomic changes. In light of our phylogenetic results, we review the species-level taxonomy of the redefined Echinosaura based on morphological and genetic variation. We resurrect E. centralis and designate a neotype given the absence of type and topotypic material. In addition, we provide taxonomic accounts for each species and analyse their patterns of geographic distribution.