bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital versus analogue chest drainage system in patients with primary spontaneous pneumothorax: a randomized controlled trial
Authors: Mooren Kris , Ruigrok Dieuwertje , Kunst Peter W.A. , Blacha Marielle M.J. , Tomlow Ben , Herbrink Jacobine W. , Japenga Eva J. , Boersma Wim , Bresser Paul , Lee Ivo van der 
Published: March 2020

Abstract
Background Patients with a primary spontaneous pneumothorax (PSP) who are treated with chest tube drainage are traditionally connected to an analogue chest drainage system, containing a water seal and using a visual method of monitoring air leakage. Electronic systems with continuous digital monitoring of air leakage provide better insight into actual air leakage and changes in leakage over time, which may lead to a shorter length of hospital stay. Aim and methods We performed a randomized controlled trial comparing the digital with analogue system, with the aim of demonstrating that use of a digital drainage system in PSP leads to a shorter hospital stay. Results In 102 patients enrolled with PSP we found no differences in total duration of chest tube drainage and hospital stay between the groups. However, in a post-hoc analysis, excluding 19 patients needing surgery due to prolonged air leakage, hospital stay was significantly shorter in the digital group (median 1 days, IQR 1-5 days) compared to the analogue group (median 3 days, IQR 2-5 days) (p 0.014). Treatment failure occurred in 3 patients in both groups; the rate of recurrence within 12 weeks was not significantly different between groups (16% in the digital group versus 8% in the analogue group, p 0.339). Conclusion Length of hospital stay was not shorter in patients with PSP when applying a digital drainage system compared to an analogue drainage system. However, in the large subgroup of uncomplicated PSP, a significant reduction in duration of drainage and hospital stay was demonstrated with digital drainage. These findings suggests that digital drainage may be a practical alternative to manual aspiration in the management of PSP. Trial registration: https://www.trialregister.nl/trial/4022. Registered 22 September 2013 - Retrospectively registered, Trial NL4022 (NTR4195)
Combined Signaling of NF-kappaB and IL-17 Contributes to Mesenchymal Stem Cells-Mediated Protection for Paraquat-induced Acute Lung Injury
Authors: Zhang Lichun , wang Yu , Shen Haitao , Zhao Min 
Published: March 2020

Abstract
Background: Paraquat (PQ) is a widely used herbicide and it can cause pulmonary toxicity and even acute lung injury. Treatment for PQ poisoning in a timely manner is still a challenge for clinicians. Mesenchymal stem cell (MSC) transplantation has hold much potentials for the treatment of several diseases including PQ poisoning. The aim of this study is to examine the mechanisms that MSCs mediate for the protective role in PQ poisoning.Methods: Here we performed the whole genome sequencing and compared the genes or pathways in lungs that were altered by PQ or PQ together with transplanted MSCs.Results: The comparison in transcriptome identified a combined mitigation in NF-kappaB signaling and IL-17 signaling in MSC transplanted samples.Conclusion: This study not only reiterates the important role of NF-kappaB signaling and IL-17 signaling in the pathogenesis of PQ-induced toxicity, but also provides a molecular basis of MSC administration for the treatment of PQ poisoning.
miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14
Authors: Ding Li , Gao Xiang , Yu Shenghui , Sheng Liufang 
Published: March 2020

Abstract
Background: To investigate the role of miR-128-3p and MAPK14 in the dexmedetomidine treatment of acute lung injury in septic mice. Methods: SPF C57BL/6 mice were divided into 8 groups. The pathological changes and wet/dry weight ratio (W/D), PaO 2 , PaCO 2 , MDA, SOD and MPO levels in lung tissue and the serum levels of inflammation factors were observed. Dual luciferase reporter assay was used to detect the targeting relationship of miR-128-3p and MAPK14, and qPCR and WB were used to detect the expression of miR-128-3p and MAPK14. Results: Compared with the Normal group, other groups had lower MDA, MPO, inflammatory factors levels and the expression level of MAPK14, while the content of SOD and the expression level of miR-128-3p was significantly decreased (all p < 0.05). Compared with the Model group, the contents of MDA, MPO, inflammatory factors in the DEX group and miR-128-3p mimic group were significantly decreased, and the content SOD was significantly increased, however, opposite results were occurred in oe-MAPK14 group (all p < 0.05). Compared with the DEX group, all the indicators in miR-128-3p mimic+DEX group showed significant improvement (all p < 0.05). Compared with the miR-128-3p mimic group, all the indicators were deteriorated in the miR-128-3p mimic+oe-MAPK14 group (all p < 0.05). The combination of DEX and oe-MAPK14 blocked the protective effect of dexmedetomidine on acute lung injury in septic mice. Conclusion: miR-128-3p can further enhance the protective effect of dexmedetomidine on acute lung injury in septic mice by targeting and inhibiting MAPK14 expression.
Data Driven Decision Making to Characterize Clinical Personas of Parents of Children with Cystic Fibrosis: A Mixed Methods Study
Authors: Szczesniak Rhonda , Pestian Teresa , Duan Leo L , Li Dan , Stamper Sophia , Ferrara Brycen , Kramer Elizabeth , Clancy John P , Grossoehme Daniel 
Published: March 2020

Abstract
Background: Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features inform patterns of adherence to pulmonary therapies and how these patterns can be used to develop clinical personas, defined as aspects of adherence barriers that are presented by parents and/or perceived by clinicians, in order to enhance personalized CF care delivery. Methods: We undertook an explanatory sequential mixed-methods study consisting of i) multivariate clustering to create clusters corresponding to parental adherence patterns (quantitative phase); ii) parental participant interviews to create clinical personas interpreted from clustering (qualitative phase). Clinical, demographic and psychosocial features were used in supervised clustering against clinical endpoints, which included adherence to airway clearance and aerosolized medications and self-efficacy score, which was used as a feature for modeling adherence. Clinical implications were developed for each persona by combing quantitative and qualitative data (integration phase). Results: The quantitative phase showed that the 87 parent participants were segmented into three distinct patterns of adherence based on use of aerosolized medication and practice of airway clearance. Patterns were primarily influenced by self-efficacy, distance to CF care center and child BMI percentile. The two key patterns that emerged for the self-efficacy model were most heavily influenced by distance to CF care center and child BMI percentile. Eight clinical personas were developed in the qualitative phase from parent and clinician participant feedback of these models. Findings from the integration phase include recommendations to overcome specific challenges with maintaining treatment regimens and increasing support from social networks. Conclusions: Adherence patterns from multivariate models and resulting parent personas with their corresponding clinical implications have utility as clinical decision support tools and capabilities for tailoring intervention study designs that promote adherence.
Expression of tripartite motif-containing 44 and its prognostic and clinicopathological values in human malignancies: a meta-analysis
Authors: Xiao Guoliang , Yang Qiuxi , Bao Ziwei , Mao Haixia , Zhang Yi , Lin Shibu 
Published: March 2020

Abstract
Background: Previous researches reported that tripartite motif-containing 44 (TRIM44) were related to prognosis in multiple human tumors. This study was designed to systematically assess the prognostic value of TRIM44 in human malignancies and to describe its possible mechanisms of oncogenesis.Methods: available databases worldwide were searched for eligible studies that evaluated the clinicopathological and prognostic roles of TRIM44 in patients with malignancies.The hazard ratio (HR) and combined odds ratios (ORs) were combined to assess the predictive role of TRIM44 using Stata/SE 14.1 software.Results: A total of 1,740 patients from thirteen original studies were included in this study finally. The results of the combined analysis showed that over-expression of TRIM44 was significantly correlated with shorter overall survival (OS) in cancer patients (HR = 2.16, 95% CI: 1.65–2.83) as well as worse disease-free survival (DFS) (HR= 2.13 (95% CI 1.45 3.11). Additionally, the combined ORs indicated that elevated TRIM44 expression was significantly associated with lymph node metastasis (OR=2.69, 95% CI: 1.71–4.24), distant metastasis (OR=10.35, 95% CI: 1.01-106.24), poor tumor differentiation (OR=1.78, 95% CI: 1.03–3.09), high depth of tumor invasion (OR=2.72, 95% CI: 1.73–4.30), advanced clinical stage (OR=2.75, 95% CI: 2.04-3.71), and recurrence (OR=2.30, 95% CI: 1.34–3.95). Analysis of expression using GEPIA indicated that the expression of TRIM44 was higher in most tumor tissues than the corresponding normal tissues.Survival analysis indicated high levels of TRIM44 mRNA were associated with unfavorable OS and DFS in various malignancies .Conclusions: TRIM44 may serve as a valuable prognostic biomarker and a potential therapeutic target for patients with malignancies.
The Effect Of Usability Perception And Easy Perception Of Real Use In Online Purchasing Transactions
Authors: Rahman Surya Adi , Adhitya Fajar , Erlandika Novan 
Published: February 2020

This study aims to determine instagram users in the needs of product purchase transactions by including variables of perceived usefulness, perceived ease of use, intentin to use and actual usage system. The sample used in this study is Instagram users who have made product purchases through Instagram among Semarang students, the number of respondents is 65 students. This study uses multiple linear regression analysis method. From the results of this study indicate that directly variable perceived usefulness, perceived ease of use influence directly actual usage system and indirectly directly perceived usefulness, perceived ease of ose influence directly to actual usage system through intention to use.
Pemisahan Anomali Regional dan Residual Data Gayaberat Studi Kasus di Kota Lama Semarang
Authors: Supriyadi Supriyadi , Khumaedi Khumaedi , Sugiyanto Sugiyanto , Setiaswan F 
Published: February 2020

Telah dilakukan penelitian dengan menggunakan metode gayaberat untuk mengidentifikasi struktur bawah permukaan di Kawasan Kota Lama Semarang sebagai survei awal untuk keperluan mitigasi bencana. Pengolahan data gayaberat untuk mengidentifikasi struktur bawah permukaan dilakukan melalui beberapa tahapan. Tahap awal dilakukan dengan koreksi awal berupa koreksi pasang surut dan koreksi apungan, kemudian dilakukan koreksi lanjut hingga didapat kontur anomali Bouguer lengkap. Melalui anomali Bouguer lengkap dapat dipisahkan anomali gaya berat regional dan residual. Pemisahan anomali regional dari anomali Bouguer dalam penelitian ini menggunakan metode <em>moving average </em>(perata-rataan bergerak) sedangkan anomali residual didapatkan dengan cara mengurangkan anomali Bouguer dengan anomali regional. Pemisahan anomali regional dan residual penting untuk dilakukan pada penelitian identifikasi struktur bawah permukaan untuk menginterpretasikan struktur geologi dan mendapatkan target yang dicari. Nilai anomali regional di Kawasan Kota Lama Semarang antara 28.0 mGal – 28.4 mGal sedangkan untuk anomali residual memiliki antara 31.6 mGal – 32.8 mGal.
The Role of Serum Procalcitonin Level as an Early Marker of Ascitic Fluid Infection in Post Hepatitic Cirrhotic Patients
Authors: Abu Rahma Mohamed Zakaria , Mahran Zainab Gaber , Shafik Engy Adel , Mohareb Dina Ahmed , Abd El-Rady Nessren M. , Mustafa Mohamed A. , Khalil Mahmoud , Abo-Amer Yousry Esam-Eldin , Abd-Elsalam Sherief 
Published: March 2020

Aims & Background:
The early diagnosis of spontaneous bacterial peritonitis (SBP) has
been considered important in the overall patient’s survival. Ascitic fluid culture examination performance,
in the emergency setting, is time-consuming and not always available, so there is a need for
easy to apply, rapid and reliable markers for diagnosis of patients with ascites. The present prospective
study aimed to determine the early diagnostic value of serum procalcitonin (PCT) levels in decompensated
cirrhotic patients (DCPs) with SBP.

Methods:
47 HCV cirrhotic patients with ascites were enrolled for this prospective study. The severity
of cirrhosis was classified based on the Child–Pugh criteria. All patients were subjected to paracentesis
and ascitic fluid (AF) culture. Serum PCT levels were measured using enzyme-linked fluorescence
analysis (ELFA).

Results:
The diagnostic value of serum PCT levels and WBC/PLT ratios for detecting infections
were serum PCT levels (3.63 ± 3.47 ng/mL) in DCPs with infections which were significantly higher
than in DCPs without infections (0.505 ± 0.230 ng/mL); p < 0.05. The cut-off value for serum
PCT levels was 0.7 ng/mL for the diagnosis of infections in DCPs, for which the sensitivity and
specificity were 93.1% and 73.2%, respectively. The AUC was 0.91 (95% CI: 0.83-0.99).

Conclusions:
Serum procalcitonin seems to provide satisfactory diagnostic biomarkers in SBP.
Cystic Echinococcosis in Children: High Frequency of Multiple Organs Involved in the North of Iran
Authors: Mohammadi Mohsen , Mamishi Setareh , Pourakbari Babak , Faraz Zahra , Khodabandeh Mahmoud , Mahmoudi Shima 
Published: February 2020

Introduction:
Echinococcosis, as an important zoonotic infection, has a major worldwide
distribution. Pediatric echinococcosis has still become health concerning issue in developing
countries, particularly, in the Middle East and Iran. The aim of this study was to investigate the human
echinococcosis in children in northern Iran.

Methods::
Patients admitted to the pediatric subspecialty hospital of Amir Kala, Babol, Iran, from
2011 to 2016 with a confirmed diagnosis of echinococcosis, were reviewed. Records of the patients,
including demographic data, clinical manifestations of the disease, type of cysts, and other
related factors, were collected.

Results:
Sixteen pediatric patients, twelve (75%) male, and four (25%) female were evaluated. All
cases had cystic echinococcosis. The results showed that fever (75%) following vomiting, nausea,
and coughing (44%) were the most common clinical manifestations. The most common localizations
of cases were determined as liver (n=10, 62.5%) and lung (n=9, 56%). The frequency of the
involvement of more than one organ was 31% (5 cases). The co-occurrence of liver and lung was
seen in 2 (12.5%) cases, and in one case, the co-occurrence of the liver and spleen was reported. In
one case, lung, liver and, the pelvis was involved, while in another case, liver, sub diaphragm and
kidney involvement were observed.

Conclusion:
Cystic echinococcosis should be kept in mind when a cystic lesion is encountered anywhere
in the body, particularly, in patients lining in the endemic regions.
Since cystic echinococcosis has a considerable economic impact in Iran, the implementation of a
control program and the surveillance system are highly recommended to reduce the economic burden
of this disease.
METODE PEMBELAJARAN BERBASIS HADIS
Authors: Rubini Rubini 
Published: February 2020

Metode pembelajaran adalah berbagai cara yang dipergunakan pendidik dalammenyampaikan bahan pelajaran kepada peserta didik, sehingga dengan metode yang tepatdan sesuai, bahan pelajaran dapat diterima dan dikuasai dengan baik oleh peserta didik.Begitu pula dengan Rasulullah SAW. Beliau menyampaikan sebuah pendidikan,pembelajaran atau pengajaran kepada para sahabat juga menggunakan berbagai macamcara atau metode, sehingga para sahabat dapat menerima, memahami dan menguasai apayang disampaikan oleh Rasulullah SAW.Beberapa metode pembelajaran yang dikemukakan dalam makalah ini, merupakanmetode – metode yang digunakan oleh Rasulullah SAW dalam menyampaikan materikepada para sahabat. Metode – metode tersebut terdiri dari metode ceramah, metodediskusi, metode keteladanan, metode tanya jawab, metode demonstrasi, metodeketeladanan, metode pembiasaan,metode mau’izahat dan nasihat, metode kisah, metodeperumpamaan, metode hadiah dan hukuman, metode gradual, metode perbandingan, danmetode menggunakan gambar.Pada dasarnya metode–metode pembelajaran yang digunakan oleh Rasulullah SAW.Hingga saat ini masih digunakan dalam dunia pendidikan, artinya begitu besar manfaatdari pada metode tersebut digunakan dari pada masa Rasulullah SAW hingga masasekarang ini dan artinya pula sudah ratusan tahun yang lalu metode – metode tersebut telahdigunakan oleh Rasulullah SAW.Learning methods are various ways conducted by educators in delivering learningmaterial to students, so that with the right and appropriate methods, learning materials canbe accepted and mastered well by students. Likewise with the Prophet Muhammad. Heconveyed that education, learning or teaching to friends also used a variety of ways ormethods, so that friends could receive, understand and master what was conveyed by theProphet Muhammad.Some of the learning methods presented in this paper are those used by theProphet Muhammad in delivering material to friends. The methods consist of lectures,discussions, exemplaries, questions and answers, demonstrations, habituations, mischiefsand advices, stories, parables, rewards and punishments, gradualism, comparisons, andusing of images. Basically those methods is still applied in the world of education, meaning thatso much benefit from the method used from the time of the Prophet Muhammad to thepresent and its meaning also hundreds of years ago these methods have been used by theProphet Muhammad.
Paradigma keilmuan Islam di perguruan tinggi
Authors: Ummah Sun Choirol 
Published: February 2020

Science and religion should be able to be completed even if they should be able to work together and complement each other. On the other hand, there is unease among scientists who consider that methodological tools in science cannot be applied in religious studies, or assume that religious values cannot help scientists find the truth. In this case, there are those who still view that both (science and religion) are single entities or positioned as isolated entities. The antithesis of both is seen in the interconnected entities model as a more advanced perspective that touches on the problem of approaches and methods and procedures. There are four typologies of the relationship between science and religion that often arise including; conflict, independence, dialogue and integration. The most recent typology that is widely used is the integration combined with interconnection. It is appropriate for universities in Indonesia to strive to get closer, integrate and connect between science and religion so that the values of life that are in the area of meaning (religion) and want to be achieved can be achieved. Sains dan agama selayaknya dapat dipersandingkan bahkan keduanya seyogyanya mampu bersinergi dan saling mengisi. Di sisi lain, ada kegamangan di antara para ilmuwan yang menganggap bahwa perangkat metodologis dalam ilmu pengetahuan tidak bisa diterapkan dalam kajian keagamaan, atau menganggap bahwa nilai-nilai agama tidak bisa membantu para saintis untuk menemukan kebenarannya. Dalam hal ini ada yang masih memandang bahwa keduanya (ilmu dan agama) merupakan single entity atau diposisikan sebagai isolated entities. Antitesis keduanya terlihat pada model interconnected entities sebagai cara pandang yang lebih maju yang menyentuh persoalan pendekatan (approach) dan metode berfikir serta penelitian (process and procedure). Ada empat tipologi hubungan sains dan agama yang sering muncul diantaranya; konflik, independen, dialog, dan integrasi. Tipologi terkini yang banyak digunakan yakni integrasi yang dikombinasikan dengan interkoneksi. Selayaknya perguruan tinggi yang ada di Indonesia berupaya keras untuk mendekatkan, mengintegrasikan dan mengoneksikan antara sains dan agama sehingga nilai-nilai kehidupan yang berada pada wilayah makna (agama) dan ingin dituju bisa tercapai.
PENINGKATAN KEMAMPUAN PRA-MEMBACA KATA PADA ANAK KELOMPOK B TK PUSIDE MUSI MELALUI MEDIA PERMAINAN KARTU HURUF
Authors: Fitriya Amalia Nur 
Published: February 2020

Penelitian ini bertujuan untuk mengetahui hasil kemampuan pra-membaca dengan menggunakan media permainan kartu huruf pada anak kelompok B di TK Puside Musi Talaud. Tujuan kedua penelitian ini adalah untuk mengetahui ada tidaknya pengaruh kemampuan pra-membaca dengan menggunakan media permainan kartu huruf pada anak kelompok B di TK Puside Musi Talaud. Penelitian ini menggunakan pendekatan kuantitatif. Populasi penelitian adalah siswa kelompok B TK Puside Musi Talaud dengan jumlah 16 orang siswa. Berdasarkan analisis data dapat disimpulkan bahwa ada pengaruh yang signifikan terhadap penggunaan kemampuan pra-membaca pada anak kelompok B di TK Puside Musi Talaud menggunakan media permainan kartu huruf. Hasil penelitian ini dalam pembelajaran pra-membaca atau membaca permulaan pada anak kelompok B peranan media sangat penting mengingat anak-anak masih amat senang bermain sambil belajar. Berdasarkan pengamatan awal di di TK Puside Musi Talaud bahwa dalam proses pra-membaca, selama ini (1) anak kurang antusias dalam mengikuti pelajaran, (2) pengenalan huruf pada anak-anak sangat terbatas, (3) guru hanya menggunakan metode ceramah. Berdasarkan hasil penelitian ini, guru menerapkan kegiatan pembelajaran pra-membaca yang menyenangkan dan inovatif dengan kartu huruf. Dengan demikian anak usia din lebih mudah mengenal huruf untuk meningkatkan kemampuan pra-membaca.Kata Kunci: kemampuan pra-membaca, anak kelompok B, permainan kartu huruf