bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLINICAL AND ANATOMICAL FORMS OF CONGENITAL CLEFT LIP AND PALATE IN THE REGION WITH ECOTOXICANTS
Authors: Чуйкин Сергей , Chuykin Sergey , Джумартов Назим , Dzhumartov Nazim , Чуйкин Олег , Chuykin Oleg , Кучук Кристина , Kuchuk Kristina , Гринь Эдуард , Grin' Eduard , Чуйкин Георгий , Chuykin Georgy , Муратов Азамат , Muratov Azamat , Гильманов Марсель , Gil'manov Marsel' 
Published: October 2019

Subject: the study of the features of clinical and anatomical forms of congenital cleft lip and palate in the region with the petrochemical industry.
Objectives ― determination of the clinical-anatomical forms of congenital cleft lip and palate, the identification of the frequency of severe forms in the region with the petrochemical industry and in the region without industrial eco-toxicants.
Methods. We have studied medical documentation in the Department of Maxillofacial Surgery of the Republican Children's Clinical Hospital for the period from January 1, 1985 to December 31, 2018 to study the structure of the clinical and anatomical forms of congenital clefts of the lips and palate in children living in the Republic of Bashkortostan. During the analyzed period, 3463 children from birth to 16 years with congenital cleft lip and palate underwent treatment and dispensary observation.
Results. Our data suggest that in the area with petrochemical ecotoxicants, the percentage of severe forms of congenital cleft lip and palate is higher (77.5%) than in an area without petrochemical ecotoxicants (68.7%).
Conclusions. Thus, environmental pollution by petrochemical ecotoxicants leads to an increase in the number of children with congenital cleft lip and palate. There is a relationship between the level of air pollution by gross emissions from petrochemical enterprises and the severity of the clinical-anatomical forms of congenital cleft lip and palate in children living in an industrial area. It is important and important in the prenatal prevention of congenital clefts of the lip and palate.
100 años de ascensión a las alturas
Authors: Ortiz Miranda Abraham 
Published: October 2019

Son 100 años de historia los que ha evidenciado el país entero al mirar al cielo. Cien años de evolución y desarrollo en los que la Fuerza Aérea Colombiana ha sido inventor de grandes gestas, hazañas éstas que sólo cumplen el único fin de salvaguardar el espacio aéreo colombiano. Sin embargo, tal centenario debe ser visto a través de un foco que permita vislumbrar la completitud y complejidad de la Fuerza a partir de aquéllos grandes hitos que realmente abran la puerta al universo del conocimiento de la misma. Es así que factores tales como el desarrollo tecnológico, la generación de nuevo conocimiento, la versatilidad y flexibilidad presentes en la aplicación del poder aéreo, y la profesionalización y constante formación del personal militar y no uniformado, son algunos de los factores preponderantes para que la Institución Castrense aquí reseñada pueda cumplir con su deber constitucional.
Para tal fin, el presente artículo cuenta con tres secciones en las que se pretenden analizar, someramente, tanto desde la génesis de la Institución como hasta sus tiempos actuales. Dos son los conjuntos de estructuras de desarrollo temporal que han marcado los cien años de la Fuerza, siendo tales dinámicas las que caracterizan los tres acápites de esta reflexión: en un principio, la mencionada entidad castrense se vio advocada a procesos de profesionalización y constante formación de su personal militar y no uniformado para enfrentar múltiples amenazas trasnacionales. Como segundo estadio, tal poder militar aéreo empezó a desarrollar conocimiento novedoso que le ha permitido ampliar sus capacidades institucionales en cuanto a versatilidad y flexibilidad se refiere. Lo anterior, ha tenido gran impacto a nivel internacional en la medida que dichos conglomerados, aún hoy vigentes, han coadyuvado para que esta entidad castrense trascienda las variadas fronteras nacionales; esta aludida labor ha tenido como objetivo el transformar y afianzar sus diferentes formas de relación intersubjetiva, lo cual ha permitido que este organismo del Estado pueda apoyar tanto a distintas naciones del mundo de manera humanitaria como a la investigación científica a la par.
RİFÂİYYENİN PÎRİ SEYYİD AHMET ER-RİFÂÎ’DE FAKR VE PRATİK TEZÂHÜRÜ FÜTÜVVET
Authors: ÇAKIR Abdullah 
Published: October 2019

Tasavvuf
terminolojisinin en önemli kavramlarından biri olan fakr, Seyyid Ahmed er-Rifâî
(ö. 1182)’nin düşüncesinde çok özel bir yer tutar. Fakr kavramı Seyyid Ahmed
er-Rifâî ile birlikte, zühd, fenâ ve kulluk kavramlarını da içerecek bir
vüs’ate kavuşmuştur. Seyyid Ahmed er-Rifâî, Kuran ve sünneti temele alan bir
tasavvufi anlayışı benimsemiş; tasavvufu, sûfiyi ve kulluğu fakr ekseninde
tanımlamış; tasavvuf düşüncesinin varlık, bilgi ve ahlaka dair bakışını fakr
esası üzerine bina etmiştir. Onun
düşüncesinde fakr sadece hakīkatin elde edildiği derûnî ve manevî bir hal
olmayıp, aynı zamanda sûfiyi Hakk’a, âleme ve insana yönelik sorumluluğa ve
hizmete davet eden aksiyonel bir tezâhürdür. Seyyid Ahmed er-Rifâî’nin tatbîkinde
kendini fütüvvet olarak gösteren bu tezâhür; züll, meskenet, mahviyet ve
acziyet olarak belirmiştir. Diğer taraftan, nefsini tüm varlıktan aşağıda
görme, kınama şeklinde değerlendirilebilecek Melâmî bir neşve olarak tezahür
etmiştir. Bu makalede, sûfîlerin fakr ve fütüvvet kavramlarına dair
görüşlerinin özet bir tasvîri yapılacak, sonrasında ise Seyyid Ahmed
er-Rifâî’nin bu kavramlara nasıl bir yaklaşım sergilediği ele alınacaktır.
17. YÜZYIL MUTASAVVIFLARINDAN KÂDİRÎ MUHYİDDÎN’İN NASÎHATNÂMESİNDE OSMANLI DEVLET İŞLEYİŞİ VE SOSYAL HAYAT
Authors: KAZANCIOĞLU Habibe 
Published: October 2019

17.
yüzyıl, Osmanlı Devleti’nin duraklama devrini yaşadığı bir dönemdir. Bu dönemde
siyasî, askerî, sosyal ve ekonomik hayatta büyük değişim ve yozlaşmalar
görülmüştür. Birçok devlet adamı, şâir ve yazarın eserine konu olan bu dönemin
bir mutasavvıf gözüyle değerlendirilmesi önemlidir.Kâdirî Muhyiddîn 17.
yüzyılda yaşamış önemli mutasavvıf ve şâirlerden olup hayatı
hakkında elimizde çok az bilgi bulunmaktadır. Elimizdeki tek eseri Nasîhatnâmesi’dir. Kâdirî
Muhyiddîn İstanbul-Kırım-Kefe şehirleri başta olmak üzere Osmanlı
coğrafyasındaki siyasî, askerî sosyal ve ekonomik
hayatı pek çok açıdan gözlemleme imkânına sahip olmuştur. Bu gözlemlerini 7997
beyitlik manzum nasîhatnâmesinde dile getirmiştir. 17. yüzyılda Osmanlı Devleti’nde
tütün ve kahve kullanımının yaygınlaşması, kahvehânelerin sayısının artması,
zina ve rüşvetin yaygınlaşması, lükse özellikle samur kürklere düşkünlüğün
artması, makamların rüşvetle alınıp satılması, devlet görevlilerinin sürekli
azledilmeleri, meşâyihlerin bozulması ve kendi aralarındaki çekişmeleri, devlet yönetiminde kadınların ve kötü
musâhiblerin etkili olması, Osmanlı askerî sisteminin bozulması ve çeşitli
tasavvufî konular, Kâdirî Muhyiddîn’in nasîhatnâmesinde
değindiği konulardan bazılarıdır. Bu
çalışmada Kâdirî Muhyiddîn’in gözüyle 17.
yüzyıl Osmanlı devlet işleyişi ve sosyal hayatı ele alınacaktır.
Acetabular Fracture Resulting from a Basketball Cutting Movement in a Young Adult Male
Authors: Sperring Thomas R. , Only Arthur J. , Wintermeyer Elke , DeRogatis Michael J. , Issack Paul S. 
Published: October 2019

Case:
We present the case of a 26-year-old man who sustained a right transverse-posterior wall acetabular fracture while performing a cutting movement playing basketball.

Conclusions:
Acetabular fracture after a relatively low-energy injury in a healthy young adult male is an extremely unusual event. The cutting movement to the right likely forcefully placed the right hip in flexion, adduction, and internal rotation directing the femoral head into the posterior wall. The patient had excellent clinical and radiographic results after acetabular open reduction and internal fixation.
The Impact of Guided Inquiry Model Integrated with Peer Instruction towards Science Process Skill and Physics Learning Achievement
Authors: Pratiwi Hestingtyas Yuli , Hudha Muhammad Nur , Asri Mathilda , Ahmad Nur Jahan 
Published: October 2019

The aim of the research is to find out the difference in science process skill and learning achievement between students who are taught using guided inquiry model integrated with peer instruction and conventional method in VII students in one of the junior high schools in Malang. The method used is quasy-experimental with only post-test group design. The sample was selected using purposive sampling technique, from the 10 population of VII grade students; the researchers selected two classes which were considered to have the same initial skill with total 32 students in each class to be the experimental class and the control class. Instruments used were the observation sheets to measure the science process skill and the test of multiple choices to measure the learning achievement. The researchers gained average score of 81 for science process skill in experimental class and 58 in control class, while the average score of 77.8 for learning achievement in experimental class and 71.3 in control class as the result of the data analysis. The hypothesis test used T-test, that was the independent sample T-test on Microsoft excel by looking up the score of Ttable on the rate of sig 0.05 for the science process skill and it gained Tcount > Ttable (18.846 > 1.669), while the learning process gained Tcount > Ttable (8.465 > 1.669). It was concluded that the guided inquiry model integrated with peer instruction can improve student’s science process skill and learning achievement compared to conventional method
Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes a retrospective study from glucagon stimulation test.
Authors: Takada Yasutaka , Fujita Yukihiro , Bessho Ryoichi , Sato Mao , Abe Tomoe , Yanagimachi Tsuyoshi , Sakagami Hidemitsu , Abiko Atsuko , Takiyama Yumi , Ota Tsuguhito , Haneda Masakazu 
Published: October 2019

Abstract
Background: Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucoseand clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucoseis associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs.
Methods: A total of 209 subjects with type 2 diabetes who underwent GST during admission were included in this cross-sectional study. We defined the difference between plasma glucose at fasting and 6 min after intravenous injection of 1 mg glucagon as Δglucose. We assessed correlations between Δglucoseand clinical parameters such as diabetic duration, BMI, HbA1c, beta cell function, serum free fatty acids (FFA) which is known to stimulate gluconeogenesis, liver function, the indices of liver function, renal function, and urinary albumin excretion (UAE).
Results: In correlation analysis, Δglucosepositively correlated to FFA and estimated glomerular filtration rate (eGFR), but inversely to serum creatinine and cystatin C, although Δglucoseshowed no correlation with both liver function and the indices of residual liver function. Multiple regression analysis revealed that Δglucose was an independent determinant for the eGFR after 1 year, equally BMI, HbA1c, serum lipids, and UAE, which are known as the predictors for the development of chronic kidney disease.
Conclusion: Our results suggest that Δglucoseduring GST might be related to gluconeogenesis in the kidney and could be the determinant of future renal function in type 2 diabetes.
Apela/Elabela/Toddler: New perspectives in molecular mechanism of heart failure
Authors: Sunjaya Anthony P , Sunjaya Angela F , Ferdinal Frans 
Published: October 2019

Background. Despite significant therapeutic advances, heart failure (HF) remains unacceptably high in morbidity and mortality. Additionally, its high-care and costs make HF a deadly and costly disease. First reported independently by two group of researchers, Apela/Elabela/Toddler (ELA) is the second endogenous apelin-receptor ligand discovered which is encoded from a previously classified non-coding gene, and has emerged as a key signalling-pathway in the cardiovascular system.Aims. To explore and summarise the biological effects and diagnostic potential of ELA as a new biomarker for heart failure.Results. ELA (prepro-ELA 54 AA) is a molecule with three isoforms (ELA 11,16 and 32), recently identified as the second endogenous ligand to APJ-receptor and functions to mediate early cardiac development during zebrafish embryogenesis by inducing cardiogenesis, vasculogenesis and bone formation. In adults, it enhances cardiac contractility, promotes vasodilatory effects, mediates fluid homeostasis, reduces food intake, limits kidney dysfunction and exerts anti- atherosclerotic as well as anti-oxidative properties.Conclusion. These results show that ELA, an endogenous agonist of the APJ-receptor exerts cardiovascular effects comparable and potentially more potent than apelin and is found to be downregulated in experimental models and humans with heart failure.
Effect of live oud music on physiological and psychological parameters in patients undergoing cardiac surgery
Authors: Luis Merna , Doss Ramy , Zayed Basel , Yacoub Magdi 
Published: October 2019

Background. Music therapy has emerged as a promising evidence-based adjuvant method of intervention. This study aims to assess the effect of live oud music on physiological and psychological parameters in patients undergoing cardiac surgery, pre- and post-operatively.Methods. Twelve patients undergoing cardiac operations were randomly allocated into either intervention group or control group, six patients in each group. Patients in the intervention group listened to 20 minutes of improvised and personally customized live oud music before and after surgery while patients in the control group heard the normal hospital sounds. While anxiety scores were assessed preoperatively, vital signs and pain scores were assessed postoperatively together with serum levels of cortisol, which was used as a surrogate marker of the stress response.Results. In the intervention group, pain scores and respiratory rates showed statistically significant reduction after listening to music (P values of 0.043 and 0.034 respectively). Additionally, heart rates, anxiety scores and serum cortisol levels showed borderline significant reduction in patients who listened to music with P values, 0.063, 0.066 and 0.068 respectively. These changes were not found in the control group.Conclusions. This preliminary study suggests a role of live oud music therapy in decreasing stress response of the patients undergoing cardiac surgery, in addition to its positive effects on pain perception and anxiety scores.
Characterization of size, shape and pattern of flow in the neo-aorta and pulmonary artery in a patient following an innovative technique of repair for truncus arteriosus
Authors: El Sawy Amr , Nagy Mohamed , Afifi Ahmed , Hosny Hatem , Romeih Soha , Aguib Heba , Yacoub Magdi 
Published: October 2019

Background. Truncus arteriosus (TA) caries a very poor prognosis. In the absence of early correction, only 12 percent of patients born with this anomaly survive beyond one year. There is no agreement about the best method of surgical correction of this anomaly. We have devised an innovative valveless technique using autologous arterial tissue to repair TA.Objectives. Characterizing the size, shape and pattern of flow in the neo-aorta and pulmonary artery, in a patient following the new technique.Patient and Methods. Cardiac MRI and multislice CT imaging, followed by offline computerized image analysis was used in a patient aged 3 months, within 3 weeks of operating.Results. The size, shape and topology of the neo-aorta and pulmonary artery, approximated that present in normal hearts. The pattern of flow in the reconstructed vessels was laminar, throughout the cardiac cycle with minor acceleration during systole. The pulmonary regurgitation resulting from the absence of a valve occurred during late diastole, and was well tolerated. The size of the right ventricle diminished considerably following operation, and the right ventricular ejection fraction was supernormal.Conclusion. This early study in one patient provides new unique data of the size, shape, topology and pattern of flow in the neo-aorta and pulmonary artery, which appear to approximate normality. The long-term results of this promising operation need to be studied.
Küreselleşme ve Medya-Ekonomi Politiği Bağlamında Reklamveren Unsurunun Rolü: Türkiye’de Yayınlanan Reklamlarda Kültürün Aktarılması Üzerine Bir İnceleme
Authors: Yılmaz Berkant , Yaman Akyar Burcu 
Published: October 2019

Küreselleşme ve medya-ekonomi politiği bağlamında
reklamveren unsurunun rolünün incelendiği bu çalışmada, küresel ve yerel
markaların reklamlarında kültürün nasıl aktarıldığı üzerine odaklanılmıştır. Bu
çalışmanın temel amacı medya ekonomi
politiği çerçevesinde, medyanın ticari olarak yürürlüğünde rol oynayan
reklamların (2018 yılında Türk televizyonlarında en uzun süre reklamveren
markalar ve reklamları), reklamverenler boyutuna odaklanarak; medyada satın
alınan süre bakımından küresel ve yerel markalar ayrımında nasıl değişkenlik
gösterdiğini ortaya koymaktır. Aynı zamanda küresel ve yerel markaların
yayınladıkları reklamlarda kültürün nasıl yansıtıldığını tespit etmek
çalışmanın diğer önemli bir amacını oluşturmaktadır.

Bu doğrultuda içerik
analizi yöntemiyle Medya Takip Merkezinin 2018 yılında yayınladığı
raporların aylık olarak analizi gerçekleştirilerek, hangi markaların en uzun
süre medyada yer aldıkları tespit edilmiş ve bu marklar arasından ilk dört
sırada yer alan markanın (2 küresel, 2 yerel) reklamları, Hofstede’in kültürel
farklılıkları yansıtan dört öğesi (semboller, kahramanlar, ritüeller,
değerler), göstergebilimsel analiz
yöntemi kullanılarak incelenmiştir.

Elde edilen sonuçlar
ışığında, 2018 yılında en uzun süre medyada yer alan ilk dört markanın; Türk
Telekom, Algida, Turkcell ve Vodafone olduğu tespit edilmiştir. Bu markaların
reklamları analiz edildiğinde ise en çok vurgulanan kültürel göstergelerin;
birliktelik, paylaşım, milliyetçilik, samimiyet, kolektiflik ve aile kavramları
olarak tespit edilmiştir.
The Chemistry of Drugs to Treat Candida albicans
Authors: Ortiz Aurelio , Sansinenea Estibaliz 
Published: October 2019

Background::
Candida species are in various parts of the human body as commensals. However,
they can cause local mucosal infections and, sometimes, systemic infections in which Candida
species can spread to all major organs and colonize them.

Objective::
For the effective treatment of the mucosal infections and systemic life-threatening fungal
diseases, a considerably large number of antifungal drugs have been developed and used for clinical
purposes that comprise agents from four main drug classes: the polyenes, azoles, echinocandins, and
antimetabolites.

Method: :
The synthesis of some of these drugs is available, allowing synthetic modification of the
molecules to improve the biological activity against Candida species. The synthetic methodology for
each compound is reviewed.

Results: :
The use of these compounds has caused a high-level resistance against these drugs, and therefore,
new antifungal substances have been described in the last years. The organic synthesis of the
known and new compounds is reported.

Conclusion: :
This article summarizes the chemistry of the existing agents, both the old drugs and new
drugs, in the treatment of infections due to C. albicans, including the synthesis of the existing drugs.
The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology
Authors: Trojan Ewa , Bryniarska Natalia , Leśkiewicz Monika , Regulska Magdalena , Chamera Katarzyna , Szuster-Głuszczak Magdalena , Leopoldo Marcello , Lacivita Enza , Basta-Kaim Agnieszka 
Published: October 2019

:Chronic inflammatory processes within the central nervous system (CNS) are in part responsible for the development of neurodegenerative and psychiatric diseases. These processes are associated with, among other things, the increased and disturbed activation of microglia and the elevated production of proinflammatory factors. Recent studies indicated that the disruption of the process of resolution of inflammation (RoI) may be the cause of CNS disorders. It is shown that the RoI is regulated by endogenous molecules called specialized pro-resolving mediators (SPMs), which interact with specific membrane receptors. Some SPMs activate formyl peptide receptors (FPRs), which belong to the family of seven-transmembrane G protein-coupled receptors. These receptors take part not only in the proinflammatory response but also in the resolution of the inflammation process. Therefore, the activation of FPRs might have complex consequences.:This review discusses the potential role of FPRs, and in particular the role of FPR2 subtype, in the brain under physiological and pathological conditions and their involvement in processes underlying neurodegenerative and psychiatric disorders as well as ischemia, the pathogenesis of which involves the dysfunction of inflammatory processes.
Study of HIV Resistance Mutations Against Antiretrovirals using Bioinformatics Tools
Authors: Peixoto Roca Tárcio , Nogueira Lima Felipe Souza , de Oliveira Santos Alcione , Souza Vieira Deusilene , Felipo Botelho-Souza Luan 
Published: October 2019

Background:Antiretroviral drugs to HIV-1 (ARV) are divided into classes: Nucleotide Reverse Transcriptase Inhibitors (NRTIs); Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs); Protease Inhibitors (PIs); Integrase Inhibitors (INIs); fusion inhibitors and entry Inhibitors. The occurrence of mutations developing resistance to antiretroviral drugs used in HIV treatment take place in a considerable proportion and has accumulated over its long period of therapy.Objective:This study aimed to identify resistance mutations to antiretrovirals used in the treatment of HIV-1 in strains isolated from Brazilian territory deposited at Genbank, as well as to relate to the clinical significance and mechanism of action.Methods:Elucidation of these mutations was by comparative method of peptide sequence resulting from genes encoding therapeutic targets in HIV antiretroviral therapy (ART) of the strains with a reference sequence through bioinformatic genetic information manipulation techniques.Results:Of the 399 sequences analyzed, 121 (30.3%) had some type of mutations associated with resistance to some class of antiretroviral drug. Resistance to NNRTIs was the most prevalent, detected in 77 (63.6%) of the 121 mutated sequences, compared to NRTIs and PIs, whose resistance was detected in 60 (49.6%) and 21 (17.3%), respectively, and to INIs, only 1 (0.8%) sample showed associated resistance mutation.Conclusion:Resistance to HIV ARV was detected at a considerable rate of 30.3%, showing some concerns about the percentage of viral strains that escape the established therapeutic regimen and that circulate currently in Brazil. The non-use of NNRTIs in Brazil is justified by the emergence of resistance mutations. The low prevalence of mutations against INIs is because drugs in this class have a high genetic barrier.