bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing total hip arthroplasty and hemiarthroplasty for the treatment of displaced femoral neck fracture in the active elderly over 75 years old: a systematic review and meta-analysis of randomized control trials
Authors: Liu Yijun , Chen Xiaokun , Zhang Peixun , Jiang Baoguo 
Published: June 2020

Abstract
Background
Displaced femoral neck fractures (DFNF) are increasingly common in elderly patients. Hip arthroplasty, the recommended treatment of DFNF, consists of the total hip arthroplasty (THA) and hemiarthroplasty (HA). THA is superior to HA in younger patients. However, there are concerns whether the more substantial surgical trauma and higher dislocation rate would trade off the advantages of THA due to frailty and lower physical demands in the elderly over 75 years.

Methods
We conducted the literature search by searching PubMed, Embase, the Cochrane Library, ClinicalTrials.gov, and Web of Science from the inception dates to June 1, 2019. Randomized controlled trials (RCTs) were included according to the inclusion and exclusion criteria. Included studies were analyzed according to Cochrane review methods.

Results
Nine studies met the inclusion criteria totaling 631 participants (301 THA and 330 HA). Four of the studies conducted were identical to a previous study but look at different follow-up periods. Our study revealed that THA was superior in terms of pain HHS, total HHS, EQ-5D, and acetabulum erosion, with a trend of a lower mortality rate within 6 months after surgery. However, the THA group had a longer average operative time and higher dislocation rate, with a trend towards a higher general complication rate. Moreover, there was no significant difference in terms of reoperation rate, postoperative infection, peri-prosthetic fracture, and VTE prevalence across the groups.

Conclusions
THA may be a preferred management option for active elderly patients over 75 years old, which can provide superior hip function and life quality with acceptable risks. Strict management should be followed to prevent dislocation following a THA, especially within the first 6 months.

Trial registration
This study was registered at the International Prospective Register of Systematic Reviews (CRD42019139135).
Medical exercise therapy alone versus arthroscopic partial meniscectomy followed by medical exercise therapy for degenerative meniscal tear: a systematic review and meta-analysis of randomized controlled trials
Authors: Ma Jianxiong , Chen Hengting , Liu Aifeng , Cui Yuhong , Ma Xinlong 
Published: June 2020

Abstract
Objective
To explore if medical exercise therapy (MET) alone is comparable to arthroscopic partial meniscectomy (APM) followed by MET for knee pain, activity level, and physical function in middle-aged patients with degenerative meniscal tear (DMT) by a systematic review and meta-analysis of randomized controlled trials (RCTs).

Method
A systematic search of electronic databases (PubMed, the Cochrane Library, Embase, and Web of Science) was conducted to retrieve RCTs comparing MET+APM with MET alone for DMT. Risk of bias of the studies was evaluated. Outcomes assessed were pain relief, physical function, and activity level.

Results
A total of 6 RCTs containing 879 patients were included. After pooling the data of 5 researches, we found small significant differences support the APM + MET group for pain control assessed by Knee injury and Osteoarthritis Outcome Score (KOOS) at 2 to 3 months (p = 0.004) and at 6 months (p = 0.04). And there were statistically improvements in APM + MET at 6 months compared with MET alone when changing measurement to visual analog scale (VAS) (p = 0.0003). Our analysis also found small significant differences favor the APM followed by MET group for physical function both at 2 to 3 months (p = 0.01, KOOS and Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC; and P = 0.40, Lysholm Knee Scoring Scale) and at 6 months (p = 0.01, KOOS and WOMAC).

Conclusion
We found favorable results of APM + MET up to 6 months for pain control and physical function. However, there were no differences at longer follow-up. The clinical applicability of APM + MET compared with MET should be interpreted carefully, and the potential of MET to treat DMT should be valued.
Clinical experience of whole-body computed tomography as the initial evaluation tool after extracorporeal cardiopulmonary resuscitation in patients of out-of-hospital cardiac arrest
Authors: Yang Kelvin Jeason , Wang Chih-Hsien , Huang Yu-Cheng , Tseng Li-Jung , Chen Yih-Sharng , Yu Hsi-Yu 
Published: June 2020

Abstract
Background
The routine application of whole-body CT after extracorporeal cardiopulmonary resuscitation (ECPR) in out-of-hospital cardiac arrest (OHCA) has not been extensively investigated. We aimed to evaluate the benefit of CT in this context.

Methods
We retrospectively analyzed all OHCA patients who had received ECPR between January 2006 to May 2019. Electronic records were reviewed to filter out patients who had a whole-body CT as their first clinical evaluation after ECPR. CT findings and major hospital outcomes were evaluated.

Results
From January 2006 to May 2019, 700 patients had received ECPR in our institution. We identified 93 OHCA patients who received whole-body CT as the first clinical evaluation after ECPR. 22.6% of those had no acute findings detected on CT requiring immediate treatment. In the remaining 77.4%, CT had findings that might lead to alterations in clinical course. Most important findings were myocardial infarction (57.0%), hypoxic brain injury (29.0%), sternal/rib fractures (16.1%), aortic dissection (7.5%), pulmonary embolism (5.4%), and cardiac tamponade (5.4%). There were no significant differences in ICU/hospitalization days, time on ECMO support, survival and neurological outcomes between those with and without immediate CT. In our OHCA cohort, there were 27 patients with CT evidence of hypoxic brain injury, of whom 22.2% (n = 2) managed to wean from ECMO support, 14.8% (n = 4) survived to discharge, but only 3.7% (n = 1) survived with good neurological outcome. Hypoxic brain injury on CT has a 95% specificity in predicting poor neurological outcome, with a false positive rate of only 3.7%. Logistic regression suggested a potential correlation between CT findings of hypoxic brain injury and poor neurological outcome [Odds ratio (OR) = 12.53 (1.55 to 10.1), p = 0.02)].

Conclusions
Routine whole-body CT after ECPR in OHCA patients appears to have a limited role, as the majority is caused by ACS. However, it may be a useful tool when CPR-related injury or non-ACS causes of OHCA are suspected, as well as in cases where the cause of OHCA is unknown. On the contrary, routine brain CT may be a valuable tool in guiding anticoagulant therapy during ECMO and in aiding outcome prediction.
Childhood acute poisoning in the Italian North-West area: a six-year retrospective study
Authors: Berta Giovanni N. , Di Scipio Federica , Bosetti Francesca M. , Mognetti Barbara , Romano Federica , Carere Maria E. , Del Giudice Anna C. , Castagno Emanuele , Bondone Claudia , Urbino Antonio F. 
Published: June 2020

Abstract
Background
Data about acute poisoning in Italian pediatric patients are obsolete or absent. This study would partially fill this exiting gap and compare the scene with others around the world.

Methods
A retrospective evaluation was performed on a 2012–2017 data registry of the Children’s Emergency Department at the Regina Margherita Hospital of Turin, where 1030 children under age 14 were accepted with a diagnosis of acute intoxication.

Results
The median age of the patients was 2.2 years (IQR 2.3) and 55% were male. Events occurred mostly in children aged 1–4 years (n = 751, 72.9%). Six hundred and eight patients (59%) were exposed to Nonpharmaceutical agents, the household cleaning products being the more frequent (n = 298, 49%). Exposure to Pharmaceuticals were 422 (41%); the most common Pharmaceuticals were analgesics (n = 88, 20.8%), psychotropics (n = 77, 18.2%) and cardiovascular (n = 53, 12.6%) drugs. The 85% of the intoxications occurred accidentally, the 10.6% as therapeutic error, the 2.3% as suicide attempts and the 1.5% for recreational purposes. No patient died.

Conclusions
Despite acute poisoning being a relevant problem in pediatric emergency, our results would seem to paint a less worrying picture if compared to other countries, mainly when considering the children hospitalized in the pediatric intensive care unit and the number of deaths. Nevertheless, our study might represent a tool for public health authorities to program incisive interventions.
Kyasanur Forest disease virus non-mouse animal models: a pilot study
Authors: Nikiforuk A. M. , Tierny K. , Cutts T. A. , Kobasa D. K. , Theriault S. S. , Cook B. W. M. 
Published: June 2020

Abstract
Objectives
Mouse models have delivered variable recapitulation of Kyasanur Forest disease (KFD) pathology and consistently demonstrated neurological involvement which may be a limited feature of human disease. With the purpose of more accurately modelling human disease progression we infected several small-mammalian models: guinea pigs, hamsters and ferrets with a titered infectious dose of Kyasanur Forest disease virus (KFDV). Clinical indicators of disease severity were observed for seventeen days, on day eighteen a visual post-mortem analysis of visceral organs was conducted. Viral load in selected tissues was measured to infer disease signs and the establishment of viral replication.

Data description
Daily monitoring did not reveal any observable signs of illness; weight loss was minimal across species and gross pathology did not indicate severe viral infection. Tissue specific tropism and establishment of viral infection was monitored by quantitative real-time polymerase chain reaction (qRT-PCR). No viral replication was detected in ferrets (n = 0/3), but was present in the spleen of guinea pigs (n = 3/3) and the brain of hamsters (n = 3/3). Low levels of viral RNA were detected in multiple hamster tissues (kidney, liver, lung and spleen) suggesting the possibility of viral tropism and possible adaptation to the host. No serological tests were performed.
Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases
Authors: Lee Ju-Yeun , Kim Jun Pyo , Jang Hyemin , Kim Jaeho , Kang Sung Hoon , Kim Ji Sun , Lee Jongmin , Jung Young Hee , Na Duk L. , Seo Sang Won , Oh Sei Yeul , Kim Hee Jin 
Published: June 2020

Abstract
Background
The retina and the brain share anatomic, embryologic, and physiologic characteristics. Therefore, retinal imaging in patients with brain disorders has been of significant interest. Using optical coherence tomography angiography (OCTA), a novel quantitative method of measuring retinal vasculature, we aimed to evaluate radial peripapillary capillary (RPC) network density and retinal nerve fiber layer (RNFL) thickness in cognitively impaired patients and determine their association with brain imaging markers.

Methods
In this prospective cross-sectional study, a total of 69 patients (138 eyes) including 29 patients with amyloid-positive Alzheimer’s disease-related cognitive impairment (ADCI), 25 patients with subcortical vascular cognitive impairment (SVCI), and 15 amyloid-negative cognitively normal (CN) subjects were enrolled. After excluding eyes with an ophthalmologic disease or poor image quality, 117 eyes of 60 subjects were included in the final analyses. Retinal vascular [capillary density (CD) of the radial peripapillary capillary (RPC) network] and neurodegeneration markers [retinal nerve fiber layer (RNFL) thickness at four quadrants] were measured using OCTA and OCT imaging. Brain vascular (CSVD score) and neurodegeneration markers (cortical thickness) were assessed using 3D brain magnetic resonance imaging. The CD and RNFL thickness and their correlation with brain imaging markers were investigated.

Results
The SVCI group showed lower CD in the temporal quadrant of the RPC network compared to the CN group (mean (SD), 42.34 (6.29) vs 48.45 (7.08); p = 0.001). When compared to the ADCI group, the SVCI showed lower CD in the superior quadrant (mean (SD), 60.14 (6.42) vs 64.15 (6.39); p = 0. 033) as well as in the temporal quadrant (ADCI 45.76, SVCI 42.34; p = 0.048) of the RPC network. The CD was negatively correlated with CSVD score in the superior (B (95%CI), − 0.059 (− 0.097 to − 0.021); p = 0.003) and temporal (B (95%CI), − 0.048 (− 0.080 to − 0.017); p = 0.003) quadrants of the RPC network. RNFL thickness did not differ among the groups nor did it correlate with cortical thickness.

Conclusions and relevance
The microvasculature of the RPC network was related to the CSVD burden. However, the RNFL thickness did not reflect cerebral neurodegeneration. Noninvasive and rapid acquisition of the OCTA image might have the potential to be used as a screening tool to detect CSVD.
Using discrete choice experiments to measure preferences for hard to observe choice attributes to inform health policy decisions
Authors: van den Broek-Altenburg Eline , Atherly Adam 
Published: June 2020

Abstract
Background
Models of preferences in health services research (HSR) and Health Economics are often defined by readily available information, such as that captured in claims data and electronic health records. Yet many important questions about patient choices cannot be easily studied because of a lack of critical data elements. The objective of this review is to outline the advantages of using stated preferences (SP) data in health services research, and to outline how these methods can be used to evaluate choices that have not yet been offered or studied.

Main body
This article focuses on the application of DCE’s to relevant policy and health system delivery questions currently relevant, particularly in the United States. DCE’s may be helpful to collect data from patient or consumer data that we currently do not have. The article provides examples of research questions that have been answered using SP data collected with a DCE. It outlines how to construct a DCE and how to analyze the data. It also discusses the methodological challenges and emphasizes important considerations regarding the design and estimation methods.
SP data can be adopted in situations where we would like to have consumer choice data, but we currently do not. These are often hypothetical situations to analyze the decision-making process of individuals. With SP data it is possible to analyze trade-offs patients make when choosing between treatment options where these hard to measure attributes are important.

Conclusion
This paper emphasizes that a carefully designed DCE and appropriate estimation methods can open up a new world of data regarding trade-offs patients and providers in healthcare are willing to make. It updates previous “how to” guide for DCE’s for health services researchers and health economists who are not familiar with these methods or have been unwilling to use them and updates previous description of these methods with timely examples.
Comparative analysis of the effects of institutional factors and Piketty’s Hypothesis on inequality: evidence from a panel of countries
Authors: Sarkhosh-Sara Ali , Nasrollahi Khadije , Azarbayjani Karim , Bakhshi Dastjerdi Rasul 
Published: June 2020

AbstractThere are many reports on investigating the influences of institutional factors and Piketty’s Hypothesis on income inequality; nonetheless, the inequality effects of both factors are seemingly investigated separately. We hypothesize that economic freedom viewed as an institutional improvement or distortion has comparatively larger effects on inequality than the forces of income divergence introduced by Thomas Piketty. This article revisits the income inequality–(r–g) nexus and uncovers the role of economic freedom as an institutional indicator in explaining the relationship. Considering the latest inequality data of World Inequality Database (WID) and Standardized World Income Inequality (SWIID) for 82 countries over 2000–2017, an inequality model is estimated that explicitly captures the interaction effect of (r−g) and economic freedom. Reaffirming that economic freedom affects inequality in a non-linear form, we also found evidence that (r−g) raises inequality in the short run, demonstrating that preexisting holders of capital derive greater shares of income. Nevertheless, the effect of (r–g) is not as strong as that of economic freedom and is insignificant in highly unequal countries. This implies that institutional factors play a more important role than Piketty’s Hypothesis in the presence of high inequality. Furthermore, variables of inflation, gross savings rate, trade openness, and unemployment rate are shown to be the most consistently positive and significant factor and GDP per capita, government spending, natural resource rent, and tax revenue variables have negative and significant effects on the baseline estimations.
Does fertilizer adoption enhance smallholders’ commercialization? An endogenous switching regression model from northern Ethiopia
Authors: Tesfay Menasbo Gebru 
Published: June 2020

Abstract
Background
Theory of development economics emphasizes how individuals transit out of poverty. Adoption of improved agricultural technologies is one of the means that enables to facilitate the transition in developing countries. The application of yield-enhancing technologies is potentially likely to produce crop income more than what farm households consume compared to farming activities with more traditional production techniques. Inorganic fertilizer is one of modern agricultural technologies that can enhance agricultural productivity. However, the increase in crop production by itself is insufficient to improve the welfare of farm households; rather, it has to be linked to the market. Therefore, I am motivated to evaluate the potential impact of adoption of inorganic fertilizer on smallholders’ commercialization as technological change enhanced land-use intensification and crop productivity in a land-scarce economy like in rural Tigrai, northern Ethiopia.

Methodology
The study utilizes cross-sectional farm household data collected in the 2014–2015 cropping season from a randomly selected 626 farm households in rural Tigrai, northern Ethiopia. Plot-level productivity is estimated using OLS with a control function approach. The causal impact of fertilizer adoption on smallholders’ commercialization is estimated using an endogenous switching regression model to control for selection problems associated with adoption decision. While factors affecting the probability and extent of inorganic fertilizer adoptions are analyzed using a double-hurdle model (hurdle 1 for probability of adoption and hurdle 2 for the extent of adoption).

Results
The double-hurdle results show that large family size, a higher number of male and female adults affect positively and significantly adoption probability of inorganic fertilizer, while long plot distance, households headed by illiterate are key constraints for inorganic fertilizer adoption. Fertilizer adoption has positive and significant effect on plot-level productivity. Finally, adoption of inorganic fertilizer has a strong and positive impact on smallholders’ commercialization through productivity gain.

Conclusion
The finding of this study confirms the potential role of technology adoption in facilitating rural transformation as higher production from adoption of improved agricultural technologies translates into surplus products and greater ability to integrate with the output market.
Outcomes Among Homeless Patients With Non–Small-Cell Lung Cancer: A County Hospital Experience
Authors: Concannon Kyle F. , Thayer John H. , Wu Qian V. , Jenkins Isaac C. , Baik Christina S. , Linden Hannah M. 
Published: June 2020

PURPOSE: Lung cancer remains the leading cause of cancer death in the United States, with outcomes likely worsened by the presence of poorer outcomes among vulnerable populations such as the homeless. We hypothesized that homeless patients experience delays in biopsy, decreased appointment adherence, and increased overall mortality rates. METHODS: We conducted a retrospective electronic medical record–based review of all patients with non–small-cell lung cancer (NSCLC; N = 133) between September 2012 and September 2018 at an academic county hospital in Seattle, Washington. RESULTS: Of the 133 patients treated for NSCLC, 22 (17%) were homeless at the time of their treatment. Among homeless patients with localized lung cancer, the mean time from radiographic finding to biopsy was 248 days, compared with 116 days among housed patients ( P = .37). Homeless patients with advanced disease missed a mean of 26% of appointments in the year after diagnosis, compared with 16% among housed patients ( P = .03). Homeless patients with advanced NSCLC had a median survival of 0.58 years, versus 1.30 years in housed patients ( P = .48). CONCLUSION: To our knowledge, this is the first US study comparing outcomes among homeless and housed patients with NSCLC within the same institution; we found homeless patients had longer delays to biopsy, increased rates of missed appointments, and a trend toward decreased survival. This study shows potential areas where interventions could be implemented to improve lung cancer outcomes in this patient population.
Controlling Helical Pitch of Chiral Supramolecular Nanofibers Composed of Two Amphiphiles
Authors: Minakawa Muneharu , Nakagawa Makoto , Wang Ke-Hsuan , Imura Yoshiro , Kawai Takeshi 
Published: June 2020

Abstract
In a previous work, we demonstrated that an amidoamine amphiphile with a stearyl group as the alkyl chain (C18AA) and 12-hydroxystearic acid (HSA) can produce hydrogels consisting of self-assembled chiral nanofibers with a homogeneous helical structure. In this work, we investigate the effect of introducing a double bond into the alkyl chain, i.e., substituting the oleyl group for a stearyl group, on the formation of the hydrogel and the structure of the chiral nanofibers. Combining the amphiphile with the oleyl group (OleylAA) and HSA produced hydrogels, although the self-assembled chiral nanofibers in the hydrogels had a different composition, helical pitch, and diameter than those formed by C18AA and HSA mixtures. Further, we demonstrate that the chiral nanofibers can be used as a soft template for preparing chiral Au nanowires.