bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural features of synthetic glycoconjugates and efficiency of their interaction with glycoprotein receptors on the surface of hepatocytes
Authors: Nosova A. S. , Budanova Yu. A. , Sebyakin Yu. L. 
Published: November 2019

Objectives.Over the last few years, medicinal chemistry research has been focusing on the creation of molecules that can target particular body systems, organs and tissues, thus abating systemic toxicity and side effects, and, most of all, boosting therapeutic potential. This goal can be achieved through the specific interaction of such drugs with active sites of cellular receptors. For example, glycoprotein receptors that can be found on cellular surfaces in neural tissues and liver parenchyma, selectively bind various glycoproteins and glycosides, facilitating their penetration into cells. This review describes how certain parameters of ligand structure (the nature and length of the spacer between carbohydrate and non-carbohydrate fragments of the molecule, number of carbohydrate residues per molecule, etc.) influence the penetration efficiency of synthetic glycoconjugates into liver cells.Methods.This review article summarizes 75 research papers and discusses data from in vitro and in vivo experiments showing which structures of synthetic carbohydrate derivatives are optimal for targeted drug delivery into liver cells.Results.The surface of liver cells (hepatocytes) contains a significant number of asialoglycoprotein receptors (ASGP-R) that are almost never found elsewhere. This makes ASGP-R an ideal target for the directed treatment of liver diseases, including such difficult, socially important conditions as hepatocellular carcinoma and Hepatitis C. A number of various ligands and targeted (to ASGP-R) delivery systems have been designed. Such molecules always contain derivatives of mono- and disaccharides, most commonly D-glucose, D-galactose, D-lactose and N-acetylglucosamines. This review contains the chemical structures of carbohydrate-based ligands.Conclusions.Glycolipids based on D-carbohydrates, when in liposomes, facilitate penetration into liver cells by a receptor-mediated, clathrin-dependent endocytosis mechanism that is activated upon contact of the carbohydrate-containing ligand fragment with the active site of ASGP-R. It can be addressed by the use of monovalent derivatives of carbohydrates as well as polyvalent glycoconjugates. Alterations in the ligand structure and the number of liposomal modifications can boost the therapeutic effect. The distance between the liposomal surface and the carbohydrate residue (spacer length), as well as the hydrophilic-lipophilic balance of the ligand molecule, have a great effect on the affinity and cellular response.
KEBERANJAKAN FATWA DARI LEGAL OPINION MENJADI LEGAL BINDING: (Studi Kasus Fatwa DSN MUI Tentang Perbankan Syariah)
Authors: Muhammad Wildan Imaduddin 
Published: November 2019

The basic concept of fatwa in its position of binding law is legal opinion in Indonesia. But in certain cases fatwa has a legal binding which is must be obeyed by people. This article demonstrate how fatwa has a legal binding in the context of Indonesia. The objects of research specifically is banking sharia act in which it is said Islamic economy activities must be appropriate with the fatwa of national sharia council. As concluding remark, this article show the development of fatwa from legal opinion to legal binding through the constitution as represent by sharia banking act.
HelloCare: APLIKASI MANAJEMEN PENGETAHUAN BERBASIS ANDROID UNTUK TENAGA KESEHATAN
Authors: Hayurani Herika , Hamnah Hamnah , Rachmawati Ummi Azizah , Suherlan Elan 
Published: November 2019

Technology Development in the health sector is one of the main targets in mobile application development today. Sharing knowledge and experience among health workers are challenging to implement because of the lack of a place to exchange their ideas. Based on this background, we built a HelloCare application on the Android platform as an application of knowledge management for health workers. Testing of the application using the System Usability Scale (SUS) to 30 respondents consisting of nurses and physicians, the result of effectiveness is 80.88% as for satisfaction is 96.16%. We also test the application using knowledge management functions and get the average result at score 3.33871 of 5. It means that the HelloCare application is good enough to support knowledge management in the health area. Keywords: knowledge management, mobile application, health workers
ANALISA BEBAN TERHUBUNG SOLAR CELL STUDI KASUS USAHA KECIL MENENGAH WARUNG INTERNET
Authors: Sungkono Sungkono , Murtono Ari , Nugrahanto Indrawan 
Published: November 2019

Beberapa penelitian telah dilakukan untuk menghitung efisiensi penggunaan solar panel surya pada skala beban rumahan. Solar panel adalah konversi cahaya sinar matahari menjadi listrik, baik secara langsung dengan menggunakan photovoltaic, atau tidak langsung dengan menggunakan tenaga surya terkonsentrasi sehingga menghasilkan tenaga listrik. Dalam penelitian yang telah dilakukan saat ini kita mendapatkan nilai penghematan dari konsumsi tarif listrik sebesar Rp. 31.000/bulan, dengan daya luaran yang dihasilkan 0.69 kwh pemilihan jenis solar cell, charge controller, battery capacity, inverter dan load based menjadi komponen utama untuk menentukan nilai output yang dibutuhkan terhadap beban selain itu juga kondisi irradiance dari suatu wilayah. Terdapat inefisiensi dalam sistem panel surya yang terpasang di warnet Fiz Mitra Media, yang mana panel surya terpasang hanya memiliki produktifitas 1.6 Wh per WP, atau hanya 30% dari kejadian umum yang berlaku.
Pemahaman Pernikahan Kudus Suku Dawan Ditinjau Dari Kejadian 1:27-28
Authors: Mauboy Anita , Eveline Sjanette 
Published: November 2019

With the increasing number of Timorese Dawan who are married they are not in accordance with what is right before God today. Certainly making the servants of God must pay special attention and focus looking for various ways how to prevent and overcome the situation.
And this is also very important to be studied. Why? Because of the habits that practiced by the Timor Dawan tribe rampant until now and this has a negative impact on the generation of teenagers and youth of the Dawan Timor tribe.
And keep in mind that habits like this are also something evil in God's eyes. Therefore, as people who believe in God need to pay attention to this problem and find ways to prevent and improve this habit because this is something that is wrong and that is not pleasing before God.
With this, the author is burdened to examine this problem with qualitative method. So that if you wish through this research, the people of Timor Dawan can turn those bad habits into habits that are in accordance with Genesis 1: 27-28.
And this also needs to be applied by God's servants especially for God's servants who come from the Eastern Dawan tribe so that young people can see and apply their marriage properly and correctly before God and avoid bad associations that commit adultery before being blessed in the church.
The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism
Authors: Liu Xin , Qu Chuan , Shi Shaobo , Ye Tianxin , Wang Linglin , Liu Steven , Zhang Cui , Liang Jinjun , Hu Dan , Yang Bo 
Published: November 2019

AimSigma-1 receptors have been investigated and shown to play a protective role in both depression and cardiovascular disease. SA4503, known as a σ1 receptor agonist, regulates cardiac calcium and potassium channels in rat models of depression. However, it remains unknown whether SA4503 can alleviate myocardial inflammation or conduction junctions in the atrium after exposure to chronic mild stress.Methods and ResultsSprague-Dawley male rats received 28-day treatment with SA4503, simultaneously with chronic mild stress. Behavior measurements were assessed after the daily doses. Additionally, a multielectrode array assessment, electrophysiological study, immunohistochemistry analysis, histological analysis, and Western blot analysis were performed. Depression rats’ hearts showed abnormal electrical activity, including disordered excitation propagation and prolonged total activation time (TAT). In addition, atrial arrhythmias (AAs), induced by burst stimulation, showed higher incidence and longer duration in the depression group compared to the control group. These changes were related to reduced conduction junctions and enhanced spatial heterogeneity. Importantly, depressed rat hearts showed greater expression of inflammatory factors (TGF-α, IL-6, and TGF-β), more collagen distribution in the extracellular matrix, and lower expression of gap junction proteins (CX40 and CX43). Furthermore, SA4503 partially mitigated the above indices in the depression group (P &lt; 0.01 for all groups).ConclusionThese findings show the effects of the σ1R agonist SA4503; it alleviates atrial myocardial inflammation and conduction junctions after chronic mild stress. SA4503 may be the promising pharmacological agent to treat depression-related AAs by increasing conduction function, improving the expression of connexin 40 and 43, and reducing cardiac myocardial inflammation.
PERBEDAAN ZONA HAMBAT PERTUMBUHAN Staphylococcus aureus PADA BERBAGAI KONSENTRASI EKSTRAK ETANOL DAUN BIDURI SECARA IN VITRO
Authors: Mastra Nyoman 
Published: November 2019

ABSTRACTBackground Staphylococcus aureus is a pathogenic bacteria that can cause infection. Biduri leaf has antibacterial compound such as tannin, flavonoid, saponin, and polyphenol.Objective This study aimed to know the difference of growth inhibition zone of Staphylococcus aureus at the various concentration of ethanol extract of biduri leaf and to determine an effective concentration.Methods This study was the true experiment with posttest only control design, used Kirby-Bauer disk diffusion method with five concentrations (20%, 40%, 60%, 80%,100%), positive control (chloramphenicol 30 µg) and negative control (ethanol 96%).Result The result of this study showed the average of inhibition zone diameter of each concentration consecutively 26,2 mm, 28,3 mm, 29,7 mm, 31 mm and 31,5 mm. One Way Anova statistic analysis showed that the value of p is 0.000 so there is the difference of growth inhibition zone of Staphylococcus aureus at various concentrations of ethanol extract of a biduri leaf.Conclusion The conclusion of this study is there are differences in growth inhibition zone of Staphylococcus aureus at various concentrations of ethanol extract of biduri leaf and an effective concentration that can inhibit of Staphylococcus aureus is concentration 20% with mean inhibition zone is 26,2 mm. Keywords: ethanol extract of biduri leaf; Staphylococcus aureus; inhibition zone
Analisis Kontrastif Persepsi Mahasiswa terhadap Psikologi Pembelajaran dan Implikasinya terhadap Peran Guru Suatu Studi Deskriptif Kualitatif terhadap Mahasiswa Murni dan Mahasiswa Bekerja pada Program Studi Pendidikan Anak Usia Dini diUniversitas AlAzhar
Authors: Fidesrinur Fidesrinur 
Published: November 2019

Pertumbuhan yang cepat dalam Pendidikan Anak Usia Dini (PAUD) ini belum diiringi oleh ketersediaan dan kemampuan guru yang memadai. Untuk itu Perguruan Tinggi Keguruan perlu mepersiapkan calon guru yang siap mengajar sesuai dengan perkembangan ilmu terkini berdasarkan konteks pembelajaran yang dihadapi. Perbedaan latar belakang mahasiswa program studi PAUD antara mahasiswa yang berlatar belakang guru dan mahasiswa murni merupakan suatu fenomena yang menarik untuk dikaji guna memperoleh kesamaan dan perbedaan persepsi dalam menyikapi filosofi pembelajaran baik secara teori maupun praktek. Hasil kajian menunjukkan bahwa mahasiswa yang berlatar belakang guru lebih fleksibel dalam menerapkan pendekatan pembelajaran sesuai konteksnya, sedangkan mahasiswa murni lebih berorientasi pada siswa sebagaimana tuntutan perkembangan teori belajar saat ini. Perbedaan ini menunjukkan bahwa mahasiswa harus dibekali praktek pembelajaran lebih banyak dengan berbagai konteks sehingga memberikan fleksibilitas dalam pembelajaran.<p style="text-align: center;"><strong> Abstract </strong></p><p style="text-align: justify;"><em></em>The growth of Early Childhood Education (ECE) not yet supported by qualified teacher that makes early childhood education quality are low. As ECE educator producer, ECE Department of Al Azhar Indonesia University should take role on preparing teacher’s candidate to become well inform both in theoretical and practical perspectives based on contextual teaching. The differences of student’s background between transferred student and fresh student become a phenomenon toward their own teaching perspectives. The research findings show that transferred students are more flexible than fresh student in teaching where most of fresh student thinking based on the latest theory studied based on books. The implication of the study is that the fresh student should have experiences long enough in teaching with various students background. The experiences with various students background might combine the essence of theory read by the student based on contextual practices.</p>
Pesan-Pesan Kemanusiaan Novel Jenghis Khan Karya John Man: Pendekatan Struktural Genetik
Authors: Budianingsih Tri 
Published: November 2019

<p><em>Abstrak</em> - <strong>Penelitian ini mengenai pesan-pesan kemanusiaan pada novel Jenghis Khan sebuah kisah yang diangkat dari negeri Mongolia karya seorang penulis barat yang bernama John Man. Penelitian ini adalah penelitian kualitatif dengan pendekatan struktural genetik. Tujuan dari penelitian ini dilakukan untuk mengetahui sisi baik dari seorang panglima besar yang terkenal dan ditakuti di penjuru dunia dalam masanya. Metode yang digunakan dalam penelitian ini menggunakan pendekatan kualitatif dengan metode analisis isi model induktif. Dalam analisis isi kualitatif, seharusnya ditentukan apa bagian penarikan kesimpulan dari informasi yang dibuat, kepada aspek-aspek komunikator (pengalaman, pendapat dan perasaannya). Hasil penelitian menunjukkan dalam novel Jenghis Khan Karya John Man terdapat 16 informasi yang menunjukkan nilai-nilai kemanusiaan sang tokoh terhadap pesan-pesan kemanusiaan, kepedulian dan toleransi berjumlah 5 dengan presentasi 31%, kegotongroyongan dan harapan berjumlah 3 dengan presentasi 19%.</strong><strong></strong></p><p> </p><p><strong><em>Kata Kunci</em></strong><em> –</em> <em>Novel, Pesan Kemanusiaan, Struktural Genetik</em></p><p> </p><p><em>Abstract </em>– <strong>This research is about the messages and humanity in the novel Genghis Khan, a story lifted from Mongolia by a writer named John Man. This study is a qualitative research with a genetic structural approach. The purpose of this study was conducted to determine the good side of a great commander known and feared throughout the world in his time. The method used in this study used a qualitative approach with the method of inductive content analysis models. In a qualitative content analysis, it should be determined what part inference of created information to the aspects of the communicator (thoughts, opinions and feelings). The results showed on Genghis Khan novel by John Man, there are 16 information that shows the values of humanity of the hero to the messages of humanity, caring and tolerance amounts 5 with 31% presentation, mutual cooperation and hope totaling 3 with 19% presentation.</strong></p><p> </p><strong><em>Keywords </em></strong><em>– Novel, Messages of Humanity, Structural Genetic</em>
Pelatihan Motivasi Bagi Siswa Kelas XI SMA dalam Mempersiapkan Diri Menghadapi Ujian Nasional
Authors: Rahmawati Siti , Imawati Rochimah , Firmiana Masni 
Published: November 2019

<p><em>Abstrak</em> – <strong>Ujian Nasional (selanjutnya disebut UN) seperti menjadi semacam momok yang sangat menakutkan bagi kebanyakan peserta didik di seluruh Indonesia. Tak jarang sebagian dari mereka mengalami psikosomatis sebelum menjalani UN. Kondisi seperti kecemasan, motivasi mendadak turun, tidak jarang terjadi hingga mengacaukan tujuan mereka : lulus UN. Pelatihan ini diberikan untuk meningkatkan motivasi dengan memberikan treatment berupa test minat dan bakat, serta training motivasi untuk mennetukan <em>setting goal</em> </strong><strong>siswa untuk menentukan cita-cita. Setelah mengikuti pelatihan ini siswa-siswa mampu lebih mengenal diri mereka dan potensi-potensi yang dimiliki. Siswa juga merasa lebih percaya diri dan siap untuk menghadapi UN. Rasa cemas yang sering muncul dapat berkurang karena siswa sudah mampu mengidentifikasi kelebihan dan kekurangan yang ada ada dirinya. </strong></p><p class="Default"> </p><p><strong><em>Kata Kunci</em></strong> – <em>Pengaturan Tujuan</em><em>, </em><em>Masa Remaja</em><em>, Mo</em><em>tivasi</em><em>, Training</em>, <em>Ujian Nasional</em><em></em></p><p><em> </em></p><p><em>Abstract</em> - <strong>The National Examination (hereinafter referred to as UN) is like becoming a scary specter for most learners throughout Indonesia. Not infrequently some of them experience psychosomatic before doing UN. Conditions such as anxiety, sudden motivation down, not infrequently happens to disrupt their goals: pass the UN. This training is given to improve motivation by providing treatment in the form of test of interest and talent, as well as motivational training to determine the goal setting of students to determine the ideals. After attending this training the students are able to know more about themselves and their potentials. Students also feel more confident and ready to face the UN. Anxiety that often appears can be reduced because students are able to identify the advantages and disadvantages that exist there himself.</strong></p><p> </p><p><strong><em>Keywords</em></strong> – <em>Goal Setting, Adolescence, Motivation, Training</em>, <em>National Examination</em></p>
Peran Kegiatan Fun cooking dalam Kemampuan Sosial Emosional dan Bahasa Anak
Authors: Amaros Yosi , Rohita Rohita 
Published: November 2019

<p><em>Abstrak</em><strong> - </strong><strong>Penelitian ini bertujuan untuk mengetahui peran <em>fun coooking</em> dalam meningkatkan kemampuan sosial emosional dan bahasa anak di TK Al Izhar Pondok Labu, Jakarta Selatan.</strong><strong> </strong><strong>Subjek penelitian ini anak usia 5-6 tahun yang mengikuti kegiatan ekstra kurikuler <em>fun cooking</em> berjumlah 8 orang anak. Metode yang digunakan adalah pendekatan kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Kemudian data yang sudah terkumpul di triangulasi dengan jenis triangulasi teknik. Berdasarkan hasil penelitian anak, diperoleh informasi bahwa <em>fun cooking</em> memiliki peran dalam kemampuan sosio emosional dan bahasa anak. Kegiatan <em>fun cooking</em> memiliki peran dalam kemampuan bahasa anak terutama dalam memahami beberapa perintah secara bersamaan; menjawab pertanyaan yang lebih kompleks; memperkaya perbendaharaan kata; serta menuliskan nama sendiri. Sementara dalam kemampuan sosial emosional anak, <em>fun cooking</em> membuat anak mampu menaati aturan kelas; mengatur diri sendiri; berbagi dengan orang lain; menunjukkan sikap toleran; serta mengekspresikan emosi yang sesuai dengan kondisi yang ada.</strong></p><p><em>Abstract </em><strong><em> - </em></strong><strong>This study aims to determine the role of fun cooking in improving emotional social skills and language of children in kindergarten Al Izhar Pondok Labu, South Jakarta. These research subjects 5-6 years old children who take part in extracurricular fun cooking amounted to 8 children. The method used is descriptive qualitative approach with data collection technique using observation, interviews, and documentation. Then the data that have been collected in triangulation with the type of triangulation techniques. Based on the results of the study of children, there was information that the fun of cooking has a role in the socio-emotional and language abilities of children. Fun cooking activities have a role in the child's language ability, especially in understanding multiple commands simultaneously; answer more complex questions; enriching vocabulary; as well as write his own name. While the emotional social abilities of children, fun cooking to make children able to obey the rules of the classroom; self-regulating; share with others; show tolerance; and express the emotions that correspond to existing conditions.</strong></p><p><strong><em>Keywords</em></strong><em> - </em><em> Fun cooking, </em><em>L</em><em>anguage skills, </em><em>S</em><em>ocial emotional skills</em><em></em></p>
Large-scale electrical resistivity tomography in the Cheb Basin (Eger Rift) at an International Continental Drilling Program (ICDP) monitoring site to image fluid-related structures
Authors: Nickschick Tobias , Flechsig Christina , Mrlina Jan , Oppermann Frank , Löbig Felix , Günther Thomas 
Published: November 2019

Abstract. The Cheb Basin, a region of ongoing swarm earthquake activity in the western Czech Republic, is characterized by intense carbon dioxide degassing along two known fault zones – the N–S-striking Počatky–Plesná fault zone (PPZ) and the NW–SE-striking Mariánské Lázně fault zone (MLF).
The fluid pathways for the ascending CO2 of mantle origin are one of the subjects of the International Continental Scientific Drilling Program (ICDP) project “Drilling the Eger Rift” in which several geophysical surveys are currently being carried out in this area to image the topmost hundreds of meters to assess the structural situation, as existing boreholes are not sufficiently deep to characterize it. As electrical resistivity is a sensitive parameter to the presence of conductive rock fractions as liquid fluids, clay minerals, and also metallic components, a large-scale dipole–dipole experiment using a special type of electric resistivity tomography (ERT) was carried out in June 2017 in order to image fluid-relevant structures.
We used permanently placed data loggers for voltage measurements in conjunction with moving high-power current sources to generate sufficiently strong signals that could be detected all along the 6.5 km long profile with 100 and 150 m dipole spacings.
After extensive processing of time series for voltage and current using a selective stacking approach, the pseudo-section is inverted, which results in a resistivity model that allows for reliable interpretations depths of up than 1000 m. The subsurface resistivity image reveals the deposition and transition of the overlying Neogene Vildštejn and Cypris formations, but it also shows a very conductive basement of phyllites and granites that can be attributed to high salinity or rock alteration by these fluids in the tectonically stressed basement.
Distinct, narrow pathways for CO2 ascent are not observed with this kind of setup, which hints at wide degassing structures over several kilometers within the crust instead.
We also observed gravity and GPS data along this profile in order to constrain ERT results.
A gravity anomaly of ca. −9 mGal marks the deepest part of the Cheb Basin where the ERT profile indicates a large accumulation of conductive rocks, indicating a very deep weathering or alteration of the phyllitic basement due to the ascent of magmatic fluids such as CO2.
We propose a conceptual model in which certain lithologic layers act as caps for the ascending fluids based on stratigraphic records and our results from this experiment, providing a basis for future drillings in the area aimed at studying and monitoring fluids.