bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoablation for persistent and longstanding persistent atrial fibrillation: results from a multicentre European registry
Authors: Sawhney Vinit , Schilling Richard J , Providencia Rui , Cadd Matthew , Perera Dhanuka , Chatha Salman , Mercer Ben , Finlay Malcolm , Halimi Franck , Pavin Dominique , Anselme Frederic , Cebron Jean-Pierre , Chun Jongi , Schmidt Boris , Defaye Pascal , Dhillon Gurpreet , Boveda Serge , Albenque Jean-Paul , Tayebjee Muzahir , de Asmundis Carlo , Chierchia Gianbattista , Hunter Ross J 
Published: November 2019

AbstractAimsAlthough cryoballoon pulmonary vein isolation is a well-established treatment for paroxysmal atrial fibrillation (AF), it’s role in persistent AF is unclear. We examined procedural success and long-term outcomes of cryoablation in persistent and longstanding persistent AF.Methods and resultsInternational multicentre registry from three UK and eight European centres. Consecutive patients undergoing cryoablation for persistent AF included. Procedural data, complications, and follow-up were prospectively recorded. Patients were followed-up at 3, 6, and 12 months with an electrocardiogram with open access to arrhythmia nurses thereafter. Ambulatory monitoring was dictated by symptoms. Success was defined as freedom from AF or atrial tachycardia lasting &gt;30 s off antiarrhythmic drugs (AADs). Six hundred and nine consecutive cryoablation procedures. Mean procedure and fluoroscopy times were 95 ± 65 and 13 ± 10 min. Single procedure success rates were 368/602 (61%) off AADs over a median of 2.4 (1.0–4.0) years. Arrhythmia-free survival off AADs was 64% and 57% for persistent and longstanding persistent AF at 24 months of follow-up (P = 0.02). Rate of repeat ablations was 20% in persistent and 32% in longstanding persistent AF (P = 0.006). Cox regression analyses showed a significant association between duration of AF and left atrial diameter and arrhythmia recurrence [hazard ratio (HR) 1.05, P-value 0.01 and HR 1.02, P-value 0.004].ConclusionCryoablation for persistent AF is safe, fast and has good outcomes at long-term follow-up. Cryoablation is reasonable as a first line option for these patients. Short procedure times may help increase capacity of cardiac units to meet the rising demand for AF ablation. Randomised control trials are needed to compare outcomes with different techniques.
Evolutionary basis of high-frequency hearing in the cochleae of echolocators revealed by comparative genomics
Authors: Wang Hui , Zhao Hanbo , Sun Keping , Huang Xiaobin , Jin Longru , Feng Jiang 
Published: November 2019

Abstract
High-frequency hearing is important for the survival of both echolocating bats and whales, but our understanding of its genetic basis is scattered and segmented. In this study, we combined RNA-Seq and comparative genomic analyses to obtain insights into the comprehensive gene expression profile of the cochlea and the adaptive evolution of hearing-related genes. A total of 144 genes were found to have been under positive selection in various species of echolocating bats and toothed whales, 34 of which were identified to be related to hearing behavior or auditory processes. Subsequently, multiple physiological processes associated with those genes were found to have adaptively evolved in echolocating bats and toothed whales, including cochlear bony development, antioxidant activity, ion balance, and homeostatic processes, along with signal transduction. In addition, abundant convergent/parallel genes and sites were detected between different pairs of echolocator species; however, no specific hearing-related physiological pathways were enriched by them and almost all of the convergent/parallel signals were selectively neutral, as previously reported. Notably, two adaptive parallel evolved sites in TECPR2 were shown to have been under positive selection, indicating their functional importance for the evolution of echolocation and high-frequency hearing in laryngeal echolocating bats. This study deepens our understanding of the genetic bases underlying high-frequency hearing in the cochlea of echolocating bats and toothed whales.
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
Authors: Turan Volkan , Oktay Kutluk 
Published: November 2019

AbstractBACKGROUNDOocyte aging has significant clinical consequences, and yet no treatment exists to address the age-related decline in oocyte quality. The lack of progress in the treatment of oocyte aging is due to the fact that the underlying molecular mechanisms are not sufficiently understood. BRCA1 and 2 are involved in homologous DNA recombination and play essential roles in ataxia telangiectasia mutated (ATM)-mediated DNA double-strand break (DSB) repair. A growing body of laboratory, translational and clinical evidence has emerged within the past decade indicating a role for BRCA function and ATM-mediated DNA DSB repair in ovarian aging.OBJECTIVE AND RATIONALEAlthough there are several competing or complementary theories, given the growing evidence tying BRCA function and ATM-mediated DNA DSB repair mechanisms in general to ovarian aging, we performed this review encompassing basic, translational and clinical work to assess the current state of knowledge on the topic. A clear understanding of the mechanisms underlying oocyte aging may result in targeted treatments to preserve ovarian reserve and improve oocyte quality.SEARCH METHODSWe searched for published articles in the PubMed database containing key words, BRCA, BRCA1, BRCA2, Mutations, Fertility, Ovarian Reserve, Infertility, Mechanisms of Ovarian Aging, Oocyte or Oocyte DNA Repair, in the English-language literature until May 2019. We did not include abstracts or conference proceedings, with the exception of our own.OUTCOMESLaboratory studies provided robust and reproducible evidence that BRCA1 function and ATM-mediated DNA DSB repair, in general, weakens with age in oocytes of multiple species including human. In both women with BRCA mutations and BRCA-mutant mice, primordial follicle numbers are reduced and there is accelerated accumulation of DNA DSBs in oocytes. In general, women with BRCA1 mutations have lower ovarian reserves and experience earlier menopause. Laboratory evidence also supports critical role for BRCA1 and other ATM-mediated DNA DSB repair pathway members in meiotic function. When laboratory, translational and clinical evidence is considered together, BRCA-related ATM-mediated DNA DSB repair function emerges as a likely regulator of ovarian aging. Moreover, DNA damage and repair appear to be key features in chemotherapy-induced ovarian aging.WIDER IMPLICATIONSThe existing data suggest that the BRCA-related ATM-mediated DNA repair pathway is a strong candidate to be a regulator of oocyte aging, and the age-related decline of this pathway likely impairs oocyte health. This knowledge may create an opportunity to develop targeted treatments to reverse or prevent physiological or chemotherapy-induced oocyte aging. On the immediate practical side, women with BRCA or similar mutations may need to be specially counselled for fertility preservation.
Cannabis Use in Persons With Inflammatory Bowel Disease and Vulnerability to Substance Misuse
Authors: Hansen Tawnya M , Sabourin Brigitte C , Oketola Banke , Bernstein Charles N , Singh Harminder , Targownik Laura E 
Published: November 2019

Abstract

Background
It is unknown whether cannabis users self-medicating their inflammatory bowel disease (IBD) symptoms are more likely to have comorbid mental health or personality risk factors associated with an increased potential for substance misuse compared with recreational cannabis users.

Methods
We surveyed individuals with IBD about their cannabis use, their mental health symptoms, and personality risk factors associated with substance misuse. We compared risk factors for substance misuse between individuals using cannabis to manage IBD symptoms and those using cannabis recreationally.

Results
Of 201 persons with IBD who completed the questionnaire, 108 reported lifetime cannabis use. Of those, a larger proportion of Crohn’s disease patients used cannabis to manage IBD symptoms (53% [34/64] vs 28% [12/43]; P = 0.010). Individuals self-medicating with cannabis were more likely to use cannabis for coping reasons (P = 0.016) and demonstrated higher levels of impulsivity (P = 0.004) and depressive symptoms (P = 0.012) when compared with individuals using cannabis recreationally. Logistic regression revealed that cannabis was 4.1 times (P = 0.05) and 3.7 times (P = 0.05) more likely to be used for IBD symptoms by smokers and individuals with moderate–severe depressive symptoms, respectively. Individuals high in impulsivity were 4.1 times more likely to use cannabis for their IBD symptoms than those low in impulsivity (P = 0.005).

Conclusions
Persons with IBD self-medicating with cannabis have characteristics associated with increased vulnerability to substance misuse when compared with those using cannabis recreationally. Screening for mental health comorbidities and vulnerability to substance misuse should be undertaken if cannabis is to be used to treat IBD symptoms.
March and the pursuit of organizational intelligence: the interplay between procedural rationality and sensible foolishness
Authors: Ocasio William , Rhee Luke , Boynton Dylan 
Published: November 2019

AbstractMarch’s long and varied career in organization theory encompasses a number of seemingly disparate themes from rationality, to ambiguity and the garbage can model, to exploration and exploitation in organizations. We examine March’s diverse research trajectory and conclude that his different insights can be brought together under one common theme for his career: that both procedural rationality and sensible foolishness are necessary for the pursuit of organizational intelligence. Traditional models of rationality, even bounded rationality, are insufficient because goals are unstable and inconsistent, and causal ambiguity leads to myopic learning or worse. To explain the interplay between procedural rationality and sensible foolishness in organizations, we explore their role in the inter-related processes of programing, monitoring, sensemaking, search, and decision making.
Pericardial hernias in adults: a systematic review of the literature
Authors: Schizas Dimitrios , Katsaros Ioannis , Karatza Elli , Theochari Nikoletta A , Kykalos Stylianos , Nastos Constantinos , Michalopoulos Nikolaos , Avgerinos Dimitrios V , Chatzimavroudis Grigoris , Arkadopoulos Nikolaos 
Published: November 2019

Abstract

OBJECTIVES
A pericardial hernia is defined as the protrusion of abdominal viscera through the central tendon of the diaphragm into the pericardial sac. It is a rare clinical entity whose symptoms vary considerably. The objective of this study was to evaluate the clinical manifestations of and the optimal surgical treatments for pericardial hernias.

METHODS
PubMed and the Cochrane bibliographical databases were searched (last search: 20 April 2019) for studies on pericardial diaphragmatic hernias in the adult population.

RESULTS
Eighty studies met our inclusion criteria and reported on 85 patients (62 men and 23 women) with a mean age of 55.86 ± 15.79 years (mean ± standard deviation) presenting with a pericardial hernia at health care facilities. The leading aetiology was trauma (56.5%) followed by iatrogenic interventions (30.6%). The most common herniated organs were the transverse colon (49.4%) and the greater omentum (48.2%). Seventy-one patients (83.5%) underwent an open surgical repair, whereas 14 (16.5%) had a laparoscopic approach. Mesh or a patch was applied in 41.9% of cases. A postoperative morbidity rate of 16.9% was recorded, whereas the mortality rate reached 2.4%.

CONCLUSIONS
Pericardial hernia is a rare disease characterized by abdominal organs herniating into the pericardium. It requires a high degree of suspicion for early diagnosis, and all medical professionals should be encouraged to report such cases to clarify the best available therapeutic approach.
Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88)
Authors: Iampietro Mathieu , Aurine Noemie , Dhondt Kevin P , Dumont Claire , Pelissier Rodolphe , Spanier Julia , Vallve Audrey , Raoul Herve , Kalinke Ulrich , Horvat Branka 
Published: November 2019

Abstract
Interferon (IFN) type I plays a critical role in the protection of mice from lethal Nipah virus (NiV) infection, but mechanisms responsible for IFN-I induction remain unknown. In the current study, we demonstrated the critical role of the mitochondrial antiviral signaling protein signaling pathway in IFN-I production and NiV replication in murine embryonic fibroblasts in vitro, and the redundant but essential roles of both mitochondrial antiviral signaling protein and myeloid differentiation primary response 88 adaptors, but not toll/interleukin-1 receptor/resistance [TIR] domain–containing adaptor–inducing IFN-β (TRIF), in the control of NiV infection in mice. These results reveal potential novel targets for antiviral intervention and help in understanding NiV immunopathogenesis.
Pediatric patient portal use in one health system
Authors: Szilagyi Peter G , Valderrama Rebecca , Vangala Sitaram , Albertin Christina , Okikawa David , Sloyan Michael , Lopez Nathalie , Lerner Carlos F 
Published: November 2019

Abstract

Objective
The study sought to assess, for children in one large health system, (1) characteristics of active users of the patient portal (≥1 use in prior 12 months), (2) portal use by adolescents, and (3) variations in pediatric patient portal use.

Materials and Methods
We analyzed data from the electronic health record regarding pediatric portal use during 2017-2018 across a health system (39 871 pediatric patients).

Results
Altogether, 63.5% of pediatric patients were active portal users. Children (proxies) who were boys, privately insured, white, and spoke English were more likely to be active users. Common uses involved messaging with physicians, medications, allergies, letters, and laboratory results. By 15 years of age, &gt;50% of adolescents used the portal by themselves (without a proxy). Pediatric portal use varied widely across practices.

Discussion
Pediatric or adolescent portal use is quite high, but large variations exist.

Conclusion
Use of the portal for pediatric care may reflect varying pediatric patient engagement.
Bemisia tabaci (Hemiptera: Aleyrodidae) Insecticide Resistance in Shandong Province, China
Authors: Wang Fan , Liu Jin , Chen Peng , Li Hong-Yang , Ma Jing-Jing , Liu Yong-Jie , Wang Kai 
Published: November 2019

Abstract
The Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) complex comprises important pests and virus vectors in agricultural crops worldwide. In China, B. tabaci has spread to more than 20 provinces and caused severe losses of vegetables, fruits, and ornamental plants. However, B. tabaci has developed resistance to many insecticidal classes in Shandong Province, eastern China. In this study, we investigated the cryptic species, insecticide resistance and detoxifying enzymes of B. tabaci from six representative locations exhibiting severe damage in Shandong. At four of the six locations, B. tabaci Mediterranean (MED) comprised 100% of the samples collected. In a further two locations, species composition was predominantly (&gt;94%) MED with B. tabaci Middle East–Asia Minor 1 (MEAM1), comprising a low proportion (&lt;6%) of the samples collected. For all field populations, avermectin was the most effective insecticide against adult B. tabaci, pyriproxyfen had a significant effect on B. tabaci eggs and field populations were susceptible to pymetrozine. Six field populations of B. tabaci have developed low-to-moderate resistance to neonicotinoids. The detoxifying enzyme activity of carboxylesterase, glutathione S-transferase, and multifunctional oxidase were quantified. Multifunctional oxidase and glutathione S-transferase activity were positively correlated with insecticide resistance in several B. tabaci populations.
Patterns of Genomic Divergence and Signals of Selection in Sympatric and Allopatric Northeastern Pacific and Sea of Cortez Populations of the Sargo (Anisotremus davidsonii) and Longjaw Mudsucker (Gillichthys mirabilis)
Authors: Garcia Eric , Simison W Brian , Bernardi Giacomo 
Published: November 2019

AbstractStudying how isolation can impact population divergence and adaptation in co-distributed species can bring us closer to understanding how landscapes affect biodiversity. The Sargo, Anisotremus davidsonii (Haemulidae), and the Longjaw mudsucker, Gillichthys mirabilis (Gobiidae), offer a notable framework to study such mechanisms as their Pacific populations cross phylogeographic breaks at Point Conception, California, United States, and Punta Eugenia, Mexico, and are separated to those in the Sea of Cortez by the Baja California peninsula. Here, thousands of loci are genotyped from 48 Sargos and 73 mudsuckers using RADseq to characterize overall genomic divergence, and search for common patterns of putatively neutral and non-neutral structure based on outlier loci among populations with hypothesized different levels of isolation. We further search for parallels between population divergence and the total proportion of outliers, outlier FST distribution, and the proportion of outliers matching coding regions in GenBank. Statistically significant differentiation is seen across Point Conception in mudsucker (FST = 0.15), Punta Eugenia in Sargo (FST = 0.02), and on either side of the Baja California peninsula in both species (FST = 0.11 and 0.23, in Sargo and mudsucker, respectively). Each species shows structure using neutral and non-neutral loci. Finally, higher population divergence yields a more even distribution of outliers along their differentiation range but does not always translate into higher outlier proportions or higher rates in which outliers are matched to coding regions. If repeated in similar systems, observed genomic patterns might reveal speciation signatures in diverse networks of population isolation.
Transitional Ecology: embedding ecological experiments into temporary urban public art
Authors: Kay Adam D , Scherber Elizabeth , Gaitan Hunter , Lovelee Amanda 
Published: November 2019

AbstractUnderstanding the environmental consequences of urbanization is a pressing objective, and more experimental ecology in urban areas would be useful in meeting this goal. Here we introduce the concept of Transitional Ecology, which involves incorporating ecological field research into temporary public art on vacant urban land. Ecological experiments can yield useful results about urban systems over short time periods. Incorporating such experiments into temporary public art allows the space to provide diverse community benefits. Although this fusion introduces challenges for both ecologists and artists, it can also create formal and informal science training activities while raising public awareness of environmental science. We illustrate these challenges and opportunities with the Urban Flower Field, a phytoremediation project in a temporary urban park.
Spontaneous reactivation of a site-specifically placed transgene independent of copy number or DNA methylation
Authors: Wei Junjie , Dong Zhicheng , Ow David W 
Published: November 2019

Abstract
As millions of seeds are produced from a breeding line, the long-term stability of transgene expression is vital for commercial-scale production of seeds with transgenic traits. Transgenes can be silenced by epigenetic mechanisms, but reactivation of expression can occur as a result of treatment with chromatin modification inhibitors such as 5-azacytidine, from stress such as heat or UV-B, or in mutants that have acquired a defect in gene silencing. Previously, we targeted a gfp reporter gene into the tobacco (Nicotiana tabacum) genome by site-specific recombination but still found some silenced lines among independent integration events. One such line also had a second random copy and both copies showed DNA hypermethylation. To test whether removing the second copy would reactivate gfp expression, two T1 plants were backcrossed to the wild type. Whereas the silenced status was maintained in the progenies from one backcross, spontaneous partial reactivation of gfp expression was found among progenies from a second backcross. However, this reactivation did not correlate with loss of the second random copy or with a significant change in the pattern or amount of DNA hypermethylation. This finding supports the suggestion that gene reactivation does not necessarily involve loss of DNA homology or methylation.
Establishment of Reference Intervals for Alkaline Phosphatase in Pakistani Children Using a Data Mining Approach
Authors: Ahmed Sibtain , Zierk Jakob , Khan Aysha Habib 
Published: November 2019

Abstract

Objective
To establish reference intervals (RIs) for alkaline phosphatase (ALP) levels in Pakistani children using an indirect data mining approach.

Methods
ALP levels analyzed on a Siemens Advia 1800 analyzer using the International Federation of Clinical Chemistry’s photometric method for both inpatients and outpatients aged 1 to 17 years between January 2013 and December 2017, including patients from intensive care units and specialty units, were retrieved. RIs were calculated using a previously validated indirect algorithm developed by the German Society of Clinical Chemistry and Laboratory Medicine’s Working Group on Guide Limits.

Results
From a total of 108,845 results, after the exclusion of patients with multiple specimens, RIs were calculated for 24,628 males and 18,083 females with stratification into fine-grained age groups. These RIs demonstrate the complex age- and sex-related ALP dynamics occurring during physiological development.

Conclusion
The population-specific RIs serve to allow an accurate understanding of the fluctuations in analyte activity with increasing age and to support clinical decision making.
Super-Earth ingestion can explain the anomalously high metal abundances of M67 Y2235
Authors: Church Ross P , Mustill Alexander J , Liu Fan 
Published: November 2019

Abstract
We investigate the hypothesis that ingestion of a terrestrial or super-Earth planet could cause the anomalously high metal abundances seen in a turn-off star in the open cluster M67, when compared to other turn-off stars in the same cluster. We show that the mass of the convective envelope of the star is likely only 3.45 × 10−3 M⊙, and hence 5.2 M⊕ of rock is required to obtain the observed 0.128 dex metal enhancement. Rocky planets dissolve entirely in the convective envelope if they enter it with sufficiently tangential orbits: we find that the critical condition for dissolution is that the planet’s radial velocity must be less than 40% of its total velocity at the stellar surface; or, equivalently, the impact parameter must be greater than about 0.9. We model the delivery of rocky planets to the stellar surface both by planet-planet scattering in a realistic multi-planet system, and by Lidov–Kozai cycles driven by a more massive planetary or stellar companion. In both cases almost all planets that are ingested arrive at the star on grazing orbits and hence will dissolve in the surface convection zone. We conclude that super-Earth ingestion is a good explanation for the metal enhancement in M67 Y2235, and that a high-resolution spectroscopic survey of stellar abundances around the turn-off and main sequence of M67 has the potential to constrain the frequency of late-time dynamical instability in planetary systems.