bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender differences and the correlates of violent behaviors among high school students in a post‐conflict area in Indonesia
Authors: Fausiah Fitri , Turnip Sherly Saragih , Hauff Edvard 
Published: February 2020

AbstractIntroductionAdolescent violence is a public health problem worldwide. Studies show that challenging environments, such as poverty and war, increase the risk of adolescent violence. This paper aims to assess gender differences in violent behaviors among adolescents in a post‐conflict area in Indonesia. The other aim of this study is to investigate the correlates of adolescents' violent behaviors using the socio‐ecological framework.MethodsThis is a school‐based study involving 511 students from six randomly selected high schools in Kotamadya Ambon. Active and verbal violent behaviors and the potential correlates were measured and assessed using backward linear regression analyses.ResultsBoys were involved in more violent behaviors than girls. However, some of the boys and girls reported being involved in all types of violent behaviors. The most significant correlates of violent behaviors across genders were community violence exposure and some types of behavioral problems.DiscussionThis study highlighted the interconnectedness between community violence exposure and violent behaviors among adolescents living in a post‐conflict area. The study also emphasizes the association between problem behaviors and violent behaviors. The results demonstrate the importance of both reducing community violence exposure and identifying adolescents with behavioral problems in the prevention of violent behaviors.
Estrogen‐related receptor‐α promotes gallbladder cancer development by enhancing the transcription of Nectin‐4
Authors: Wang Lei , Yang MengMeng , Guo Xingmei , Yang Ziyi , Liu Shilei , Ji Yuan , Jin Huihan 
Published: February 2020

AbstractEstrogen‐related receptor‐α (ERRα) is a nuclear receptor of transcription factor that binds to estrogen responsive elements and estrogen‐related responsive elements. Estrogen‐related receptor‐α is involved in metabolic processes and implicated in the progression and growth of several human malignancies. However, the biologic role and clinical significance of ERRα in gallbladder cancer (GBC) remains to be clarified. Here, we reported that ERRα protein expression was notably higher in GBC tissues than in cholecystitis tissues, and that the aberrantly higher ERRα expression was positively correlated with advanced TNM stage and indicated dismal prognosis of GBC (P < .01). In GBC cell lines NOZ and OCUG, the targeted depletion of ERRα retarded the growth and suppressed the migration and invasive capabilities of GBC cells, and inhibited epithelial‐mesenchymal transition by decreasing the expression of mesenchymal markers and elevating the expression of epithelial markers. Moreover, ERRα knockdown inhibited tumor growth in nude mice and led to decreased expression levels of Nectin‐4, p‐PI3K p85α, and p‐AKT. Overexpression of ERRα in the GBC‐SD cell line showed exactly the opposite effect. The targeted inhibition of Nectin‐4 antagonized GBC cell proliferation and invasion, which were induced by ERRα upregulation. Moreover, Nectin‐4 depletion inhibited the ERRα‐induced activation of the PI3K/AKT pathway. Chromatin immunoprecipitation analysis and dual‐luciferase reporter gene assays showed that ERRα enhanced the transcription of Nectin‐4 by binding to the promoter of Nectin‐4. In conclusion, our data indicated that ERRα could be a potential target for the genetic treatment of GBC.
Psychotropic drug initiation in patients diagnosed with chronic myeloid leukemia: a population‐based study in France
Authors: Gauthier Martin , Conte Cécile , Palmaro Aurore , Patras De Campaigno Emilie , De Barros Sandra , Huguet Françoise , Laurent Guy , Lapeyre‐Mestre Maryse , Despas Fabien 
Published: February 2020

AbstractPsychotropic drugs (PD) are often used close to a cancer diagnosis and may be considered as a way of coping. We aimed to determine the incidence of anxiolytics, hypnotics, antidepressants, and antipsychotics initiation around a diagnosis of chronic myelogenous leukemia (CML). Population‐based cohort: Data were extracted from Systeme National des données de Santé (SNDS, the French health insurance database) at the regional level (Midi‐Pyrenees area, 2.9 million inhabitants). All newly diagnosed patients treated by a CML tyrosine kinase inhibitor (TKI) between 10/01/2011 and 04/01/2014 were included. Pre‐CML (9 months before to 3 months before first TKI prescription—F‐TKI) and CML (3 months before to 9 months after F‐TKI) phases were defined. The main evaluation criterion was the initiation of PD during CML phase. Determinants associated with this incident PD use were studied through a logistic regression model. We compared pre‐CML and CML healthcare consumption. The cohort included 103 patients (mean age of 60.8 years). PD initiation rate was 35.9%, anxiolytics being the most initiated PD (59.5%). Advanced age was associated with PD initiation (adjusted OR = 1.029, 95% CI = 1.001–1.056). The number of consultations during the pre‐CML phase and female gender tended to be associated with increased risk of PD initiation in univariate analysis. For PD initiators, healthcare consumption was greater in CML but not in pre‐CML phase. PD initiation is a frequent finding around a CML diagnosis. Its risk increases with age. It could be a way to identify a subgroup with higher healthcare consumption.
Effect of routine dental attendance on child oral health‐related quality of life: A cohort study
Authors: Menegazzo Gabriele Rissotto , Knorst Jessica Klöckner , Emmanuelli Bruno , Mendes Fausto Medeiros , Ardenghi Diego Machado , Ardenghi Thiago Machado 
Published: February 2020

AbstractBackgroundThere is an improvement in oral health status among people who receive preventive dental care during their lifetime, highlighting the possible effect in resolving oral health problems and consequently oral health‐related quality of life (OHRQoL).AimAssessed the effect of routine dental attendance on child OHRQoL.DesignThis cohort study used baseline data from 639 preschoolers from 2010. After 7 years, 449 children were re‐examined (70.3%). Mothers of the children completed a questionnaire collecting data on the pattern of use of dental services. Children were classified as adhering to long‐term routine dental attendance according to their pattern of use (routine vs curative) in the baseline and in follow‐up. The child OHRQoL was assessed through the Child Perception Questionnaire (CPQ8‐10). The association between routine dental attendance and child OHRQoL was assessed using multilevel Poisson regression models.ResultsThe proportion of participants who reported the worst CPQ8‐10 scores were higher among those who, at some point in their life, experienced a curative dental attendance. Also, the mean CPQ8‐10 was two times higher for non‐routine dental attendance.ConclusionThe findings showed that there is an impact of long‐term routine attendance on child OHRQoL. This is important for tackling oral health iniquities.
Genetic analysis provides insights into species distribution and population structure in East Atlantic horse mackerel (Trachurus trachurus and T. capensis)
Authors: Healey Amy J. E. , Farthing Matthew W. , Nunoo Francis K. E. , Potts Warren M. , Sauer Warwick H. H. , Skujina Ilze , King Nathan , de Becquevort Sophie , Shaw Paul W. , McKeown Niall J. 
Published: February 2020

AbstractTwo sister species of horse mackerel (Trachurus trachurus and T. capensis) are described that are intensively harvested in East Atlantic waters. To address long‐standing uncertainties as to their respective geographical ranges, overlap and intraspecific population structure this study combined genetic (mitochondrial DNA and microsatellite) analysis and targeted sampling of the hitherto understudied West African coast. mtDNA revealed two reciprocally monophyletic clades corresponding to each species with interspecies nuclear differentiation supported by FST values. The T. trachurus clade was found across the north‐east Atlantic down to Ghana but was absent from Angolan and South African samples. The T. capensis clade was found only in South Africa, Angola and a single Ghanaian individual. This pattern suggests that both species may overlap in the waters around Ghana. The potential for cryptic hybridization and/or indiscriminate harvesting of both species in the region is discussed. For T. capensis mtDNA supports high gene flow across the Benguela upwelling system, which fits with the species' ecology. The data add to evidence of a lack of significant genetic structure throughout the range of T. trachurus though the assumption of demographic panmixia is cautioned against. For both species, resolution of stock recruitment heterogeneity relevant to fishery management, as well as potential hybridization, will require more powerful genomic analyses.
Effect of radiotherapy on freedom from seizures in dogs with brain tumors
Authors: Monforte Monteiro Susana R. , Rossmeisl John H. , Russell Jason , Holmes Mark A. , Wessmann Annette , Morris Jo , Dobson Jane M. , Vanhaesebrouck An E. 
Published: February 2020

AbstractBackgroundSeizures are a common presenting sign in dogs with brain tumors.Hypothesis/ObjectivesTo investigate the effect of radiotherapy on freedom from brain tumor‐associated seizures and survival time in dogs.AnimalsThirty‐two client‐owned dogs with brain tumor‐associated seizures; 18 received medical treatment and radiotherapy, 14 received medical treatment alone.MethodsMulticenter retrospective study. Baseline characteristics (seizure semiology, magnetic resonance imaging [MRI] characteristics, and treatment) and duration of seizure freedom were recorded for the 2 treatment groups. Duration of seizure freedom between groups was compared (log‐rank test) using Cox's proportional hazard analysis, with baseline characteristics entered as covariates.ResultsThe duration of seizure freedom and survival time were significantly longer in the radiotherapy group (P < .001), with a mean of 24 months (95% confidence interval [CI], 14.3‐33.8) versus 1.7 months in the control group (95% CI, 0.5‐2.9) and a mean of 34.6 months (95% CI: 25.2‐44.1) versus 6.2 months in the control group (95% CI, 2.6‐9.7) respectively. Baseline characteristics were not associated with duration of seizure freedom after the start of treatment. In the radiotherapy group, 5 dogs were euthanized during the study period because of causes other than seizures. In the control group, recurrence of seizures was observed before death in all dogs.Conclusions and Clinical ImportanceA longer period of seizure freedom and longer survival time was observed in dogs with brain tumors after radiotherapy compared to medical treatment only. The pathophysiological mechanisms of epileptogenesis and the effect of radiation therapy on seizure control are unclear to date. Further prospective studies are needed.
Breathing Forth the Word: Yves Congar's Articulation of the Activity of The Holy Spirit In The Life of Christ
Authors: Brooks Adrian J. 
Published: February 2020

AbstractMuch of Yves M-J. Congar's O.P. (1904-1995) later work concentrates more explicitly on pneumatology, most famously his three-volume I believe in the Holy Spirit (1979-80). Writing shortly after its publication, Congar notes that “if he could draw only one conclusion from [his] studies on the Holy Spirit, it would concern the Spirit's bond with the Word. There is no breath without speaking or articulating something.” Congar later argues in The Word and the Spirit (1984) that the doctrines of pneumatology and Christology should not be treated separately but should inform and shape each other. This led him to develop what he termed a pneumatological Christology and a Christological pneumatology. A criticism that Congar dealt with on several occasions was that Catholic theology suffered from a form of Christomonism, whereby the Holy Spirit appeared to be subordinated to the Son, with dire consequences for the ecclesial life of the church. This essay briefly examines the accusation of Christomonism and evaluates Congar's response to it. It primarily does this by critically engaging with Congar's image of the Son as the Word and the Spirit as the Breath. As well as evaluating Congar's approach, this essay also suggests how his language could be expanded further.
Estimated basal metabolic rate and maintenance fluid volume in children: A proposal for a new equation
Authors: Amano Yoshiro 
Published: February 2020

AbstractThe basal metabolic rate (BMR) of children aged <2 years is proportional to their body weight (W; kg). However, no simple mathematical model for the estimation of BMR in children aged ≥2 years has been established. Based on Japanese studies on childhood BMR, conducted until the 1960s, we noted that childhood BMR (after infancy) is proportional to body weight to the power of 1/2 (W1/2). Moreover, we confirmed that the two previously reported equations for calculating BMR (Schofield’s equation and Oxford University’s equations) are proportional to W1/2. Based on these facts, we propose a new equation for the maintenance fluid volume for hospitalized children. Our equation (300 × W1/2 mL/day) gives values almost equal to the maintenance fluid volume calculated by the most commonly used equation of Holliday and Segar in children aged 2–18 years. Our equation will be useful for pediatricians to calculate the maintenance fluid volume for children in daily clinical settings.
Varieties of plenitude
Authors: Fairchild Maegan 
Published: February 2020

AbstractMaterial Plenitude is the view that there is an abundance of coincident objects wherever there is any material object. Although plenitude has garnered increased attention from metaphysicians in recent years, it has yet to be well‐understood beyond its slogan from. The goal of this article is to explore a few places for puzzlement about plenitude; in particular, how we ought to motivate and formulate the target view. I'll suggest along the way that an investigation of plenitude is not merely of interest in its own right, but can provide valuable insights into abundant ontologies more generally.
Assessment of infectious complications in elderly kidney transplant recipients receiving induction with anti‐thymocyte globulin vs basiliximab
Authors: Pham Christine , Kuten Samantha A. , Knight Richard J. , Nguyen Duc T. , Graviss Edward A. , Gaber A Osama 
Published: February 2020

AbstractBackgroundElderly transplant recipients experience lower rates of acute rejection with higher rates of infectious complications compared to their younger counterparts. While less intensive immunosuppression may be preferable, there are no recommendations for depleting versus non‐depleting induction strategies. We sought to compare infectious complications between anti‐thymocyte globulin (ATG) and basiliximab (IL2RA) induction in elderly kidney transplant recipients (KTRs).MethodsWe reviewed 146 KTRs ≥65 years receiving ATG or IL2RA induction. Per institution protocol, ATG was administered to patients with the following characteristics, irrespective of age: African American (AA), PRA ≥20%, and/or re‐transplantation. Infectious complications (bacterial, viral, and invasive fungal) at 1 year were compared.ResultsThere were significantly more AA, deceased donors, and sensitized KTRs in the ATG group, reflecting criteria for induction agent. ATG KTRs experienced higher rates of overall infectious complications (77% vs 56%,P = .01), driven by increased bacterial (54% vs 39%,P = .08) and viral infections (51% vs 35%,P = .05). Urinary tract infections (UTIs) and CMV in particular occurred at high rates among ATG patients (46% and 32%, respectively). In multivariate analysis, the only independent risk factor associated with increased risk for infection was induction with ATG (adjusted HR 1.71 [95% CI 1.04‐2.83],P = .04). Overall rates of immunologic outcomes were low.ConclusionElderly KTRs receiving ATG are at an increased risk for infectious complications, largely attributed to high rates of UTIs and CMV. Additional strategies aimed at mitigating these complications in elderly patients requiring ATG may be beneficial.
Predicting the duration of surgery and procedures in a veterinary referral center
Authors: Hasiuk Michelle M. M. , Pang Daniel S. J. 
Published: February 2020

AbstractObjectiveTo evaluate the ability of veterinary personnel to predict the duration of surgery and associated procedures in a referral center.Study designProspective observational study.Sample populationExperienced surgeons (ES; n = 2, board certified for 10+ years), inexperienced surgeons (IS; n = 2, residency completed, not board certified), anesthesia animal health technicians (AAHT; n = 3) and surgery animal health technicians (SAHT; n = 2).MethodsSurgeons and technicians predicted surgery duration (skin incision to final stitch/staple) and total procedure duration (TPD; from induction of anesthesia to extubation). Predictions were compared to actual durations with Bland–Altman plots to assess agreement (accuracy) as indicated by bias (mean of observed differences) and limits of agreement (LOA; bias ±1.96 SD).ResultsAll groups underestimated TPD. Experienced surgeons predicted their own TPD more accurately (bias −20.1 ± 30.4 minutes [±SD]) and more consistently (narrower LOA) than IS for their own TPD (−40.1 ± 41.0 minutes). Experienced surgeon TPD predictions by AAHT were more accurate than those by ES (bias −16.0 ± 28.9 minutes, LOA 5% narrower). Inexperienced surgeon TPD predictions by AAHT were less consistent (wider LOA) than those by IS. Own surgery duration predictions by surgeons were similar in magnitude (ES surgery duration [ESSD] 8.3 ± 18.3, IS surgery duration [ISSD] surgery duration −7.9 ± 27.2 minutes), with greater consistency by ES (LOA 30% narrower). Anesthesia animal health technician predictions were similar to those of surgeons (ESSD 3.0 ± 19.3, ISSD −9.0 ± 28.7 minutes). Surgery animal health technician predictions were similar to those of AAHT for ESSD but were less accurate for ISSD.ConclusionSurgery duration was more accurately predicted than TPD, which was most accurately predicted by anesthesia technicians.Clinical significanceSurgical procedure planning should involve personnel best able to predict total procedure durations; in this case, anesthesia technicians. Accurate planning will promote efficient operating room and personnel use.
Bilevel Flexible-Robust Optimization for Energy Allocation Problems
Authors: Biswas Arpan , Chen Yong , Gibson Nathan , Hoyle Christopher 
Published: February 2020

Abstract
A common issue in energy allocation problems is managing the tradeoff between selling surplus energy to maximize short-term revenue, versus holding surplus energy to hedge against future shortfalls. For energy allocation problems, this surplus represents resource flexibility. The decision maker has an option to sell or hold the flexibility for future use. As a decision in the current period can affect future decisions significantly, future risk evaluation of uncertainties is recommended for the current decision in which a traditional robust optimization is not efficient. Therefore, an approach to flexible-robust optimization has been formulated by integrating a real options (RO) model with the robust optimization framework. In the energy problem, the real option model evaluates the future risk, and provides the value of holding flexibility, whereas the robust optimization quantifies uncertainty and provides a robust solution of net revenue by selling flexibility. This problem is solved using bilevel programming and a complete general mathematical formulation of bilevel flexible-robust optimization model is presented for multireservoir systems and results shown to provide an efficient decision making process in energy sectors. To reduce the computational expense, mathematical techniques have been used in the proposed model to reduce the dimension in the quantification and propagation of uncertainties.
P2Y12 inhibitors with oral anticoagulation for percutaneous coronary intervention with atrial fibrillation: a systematic review and meta-analysis
Authors: Lupercio Florentino , Giancaterino Shaun , Villablanca Pedro Arturo , Han Frederick , Hoffmayer Kurt , Ho Gordon , Raissi Farshad , Krummen David , Birgersdotter-Green Ulrika , Feld Gregory , Reeves Ryan , Mahmud Ehtisham , Hsu Jonathan C 
Published: February 2020

ObjectiveThis study aimed to compare the safety and efficacy of third-generation P2Y12 inhibitors versus clopidogrel in combination with oral anticoagulation (OAC) with or without aspirin in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI).MethodsWe performed a systematic review including both prospective and retrospective studies that compared dual and triple antithrombotic regimens for bleeding and major adverse cardiac events (MACE) in patients with AF undergoing PCI. We analysed rates of bleeding and MACE by P2Y12 inhibitor choice. Risk ratio (RR) 95% CIs were measured using the Mantel-Haenszel method. Where study heterogeneity was low (I2 <25%), we used the fixed effects model, otherwise the random effects model was used.ResultsA total of 22 014 patients were analysed from the seven studies included. Among patients treated with both OAC and P2Y12 inhibitor with or without aspirin, 90% (n=9708) were treated with clopidogrel, 8% (n=830) with ticagrelor, and 2% (n=191) with prasugrel. When compared with clopidogrel, use of ticagrelor (RR 1.36; 95% CI 1.18 to 1.57) and prasugrel (RR 2.11; 95% CI 1.34 to 3.30) were associated with increased rates of bleeding. Compared with clopidogrel, there were no significant differences in rates of MACE with ticagrelor (RR 1.03; 95% CI 0.65 to 1.62) or prasugrel (RR 1.49; 95% CI 0.69 to 3.24).ConclusionBased on this meta-analysis, the use of clopidogrel is associated with a lower rate of bleeding compared with ticagrelor or prasugrel in patients with AF on OAC undergoing PCI.
Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis
Authors: Kuroi Yasuhiro , Ohbuchi Hidenori , Arai Naoyuki , Takahashi Yuichi , Hagiwara Shinji , Sasahara Atsushi , Funaki Ayako , Itoh Toshimasa , Sato Yasunori , Kasuya Hidetoshi 
Published: February 2020

ObjectiveTo develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience.MethodsOf 432 patients with aneurysmal subarachnoid hemorrhage treated between 2007 and 2019, 291 were enrolled. 97 Patients were aged >70 years (33%), 194 were female (67%), 138 were World Federation of Neurological Societies grades 1, 2, and 3 (47%), 218 were Fisher group 3 (75%), and 243 had an anterior circulation aneurysm (84%). Using a propensity score matching method for these five factors, the severity of cerebral vasospasm, occurrence of delayed cerebral infarction, and modified Rankin Scale (mRS) score at discharge were analyzed.ResultsOne hundred patients each with or without NPRI were selected, and the ratios of coil/clip were 0/100 and 88/12, respectively. Cerebral vasospasm and delayed cerebral infarction were both significantly less common in the NPRI group (p=0.004, OR=0.412 (95% CI 0.223 to 0.760) and p=0.005, OR=0.272 (95% CI 0.103 to 0.714, respectively); a significant difference was seen in the mRS score at discharge by Fisher’s exact test (p=0.0025). A mRS score of 6 (dead) was less common in the group with NPRI, and mRS scores of 0 and 1 were also less common. No side effects were seen.ConclusionsNPRIs significantly reduced the occurrence of cerebral vasospasm and delayed cerebral infraction without any side effects. The NPRI and non-NPRI groups showed different patterns of short-term outcomes in the single critical care center, which might have been due to selection bias and patient characteristics. Differences in outcomes may become clear in comparisons with patients treated by craniotomy.