bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forage production in tall fescue and kikuyugrass mixed swards subjected to different defoliation strategies
Authors: Winter Fábio L. , Pittaro Maria G. , Schmitt Daniel , Moncada Valentina Y. M. , de Mello Guilherme R. , Miqueloto Tiago , Bernardon Angela , Barreta Daniel A. , Garzón‐Camacho Pedro A. , Sbrissia André F. 
Published: December 2024

AbstractIn some temperate climate regions, co‐cultivation of warm‐ and cool‐season perennial grass species represents a promising alternative for sustainable food production. However, managing these pastures is challenging, particularly because of intra‐annual competition, which can lead to some species suppressing others. This 3‐year study investigated the effects of different defoliation strategies on mixed pastures composed of tall fescue (Schedonorus arundinaceum Schreb; Tf) and kikuyugrass (Cenchrus clandestinus Hochst. ex Chiov; Ky). Treatments were factorial combinations (two × two) of pre‐grazing canopy heights (15 and 20 cm) and the presence or absence of a single clean‐up grazing event during the spring (SCG). Pre‐grazing canopy height and SCG significantly influenced annual forage accumulation (p < 0.05), but there was no interaction between them (p > 0.05). Swards managed at 20 cm or subjected to SCG presented a 10% greater forage production (approximately 15,432 kg DM ha−1) than those managed at 15 cm or without SCG (14,067 kg DM ha−1). All the treatments presented higher intra‐ and inter‐annual stability in forage production (<30% coefficient of variation). The greater annual forage accumulation was mostly attributed to increments in Tf leaf area index and Ky tiller population density over the seasons. Our study demonstrated that in a mixed sward of warm‐ and cool‐season perennial grasses, both the pre‐grazing canopy height and the presence of an SCG influence year‐round forage production by changing their canopy attributes.
The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies
Authors: Wyman‐Chick Kathryn A. , Barrett Matthew J. , Miller Michael J. , Sargent Lana , Chrenka Ella A. B. , Kane Joseph P. M. , Crowley Samuel J. , Kuntz Jennifer L. , Parashos Sotirios A. , Schousboe John T. , Nguyen Huong , Werner Ann M. , Rossom Rebecca C. 
Published: December 2024

AbstractINTRODUCTIONLittle is known regarding the relationship between anticholinergic medications and frailty in dementia with Lewy bodies (DLB).METHODSAnticholinergic Cognitive Burden Scale (ACB) and Claims‐based Frailty Index scores were calculated for 12 months prior to the dementia diagnosis using electronic medical record and claims data. Logistic regression was used to estimate the association between ACB and odds of frailty.RESULTSCompared to controls (n = 525), a diagnosis of DLB (n = 175; adjusted odds ratio [aOR]: 15.1, 95% confidence interval [CI]: 7.0–33.9) or Alzheimer's disease (AD: n = 525; aOR = 7.7, 95% CI: 4.4–13.7) was associated with an increased odds of frailty. Patients with DLB had greater prescriptions for anticholinergic medications than patients with AD (pB < 0.001; 23% vs 9.7%). ACB was positively correlated with frailty for all groups (r = 0.30 to 0.47, p < 0.001).DISCUSSIONCumulative anticholinergic burden may be a modifiable predictor of frailty among older adults, including those newly diagnosed with dementia.Highlights
Patients with newly diagnosed dementia with Lewy bodies (DLB) are more likely to have prescriptions for anticholinergic medications relative to patients newly diagnosed with Alzheimer's disease (AD) and older adults without documented cognitive impairment.
In the year prior to a documented dementia diagnosis, 74% of patients with DLB and 66% of patients with AD had evidence of frailty.
Anticholinergic medication burden was associated with frailty among all older adults in the study, including those without a dementia diagnosis.
An Improved GC–MS/MS Method for a Fast Multidrug Analysis in Hair
Authors: Zhang HuiFen Hannah , Loh Jia Ying Hilda , Moy Hooi Yan , Lui Chi Pang 
Published: December 2024

ABSTRACTThis study presents the development and validation of a drug testing method in hair, employing a semi‐automated sample preparation procedure and gas chromatography–tandem mass spectrometry (GC–MS/MS) for simultaneous multidrug analysis in hair. The method aims to detect and quantify multiple drugs in hair, including amphetamine, methamphetamine, 3,4‐methylenedioxyamphetamine, 3,4‐methylenedioxymethamphetamine, ketamine, norketamine, cocaine, benzoylecgonine, morphine, codeine and 6‐monoacetylmorphine, using a comprehensive procedure involving decontamination, pulverization, clean‐up using supported‐liquid extraction (SLE) and a two‐step derivatization process. The method validation included specificity, linearity, limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, carryover, robustness and stability. The results indicate a linearity range of 0.1–5 ng/mg for all drugs except methamphetamine, which has a linearity range of 0.2–5 ng/mg. The accuracy and precision of the method are within ±20%, with the LOQ at 0.2 ng/mg for methamphetamine, 0.1 ng/mg for amphetamine and MDMA and 0.05 ng/mg for the rest of the drugs. The LODs were found to be 0.1 ng/mg for methamphetamine, 0.05 ng/mg for amphetamine and MDMA and 0.025 ng/mg for other drugs. This method has demonstrated its accuracy by comparing the quantitative test results with the expected results, using hair samples from the proficiency test service providers. This test method offers efficient testing of multiple drugs in a single analysis, significantly improves the hair analysis workflow in a routine testing laboratory by reducing turnaround time and the amount of hair sample required.
Iodine‐Assisted Regioselective C3‐H Chalcogenation of 4‐Phenyl Aminocoumarin: Access to Unusual Dual Selenylation of N‐Substituted Derivatives
Authors: Singh Sahay Suhag , Rahaman Segufa , Das Rwishanya , Dey Swapan 
Published: December 2024

AbstractA simple, efficient, metal and photocatalyst‐free, eco‐friendly approach for the C3‐H regioselective chalcogenation of 4‐phenyl aminocoumarin, as well as abnormal dual selenylation of N‐substituted 4‐phenyl aminocoumarin, has been developed by using diphenyl dichalcogenides and iodine as support in green solvent PEG‐400 under ambient temperature and aerobic condition. Furthermore, chalcogenation of 4‐phenyl amino‐2‐pyrone has also been accomplished in similar conditions. The proposed mechanism is based on the control experiments and suggests an ionic pathway. The reaction offers a green synthetic path with a high yield, and the methodology is crucially significant due to its operational simplicity, convenient execution, scalability, and tolerance of various functional groups.
Abscisic acid improves the phytoremediation ability of the aquatic accumulator plant Nasturtium officinale R. Br. in cadmium‐contaminated soil
Authors: Peng Xuemei , Xiao Yunying , Tang Wanjia , Dai Zhen , Zhang Dilian , Zheng Yangxia , Lin Lijin 
Published: December 2024

AbstractPrevious studies report significant contamination of farmland soil by cadmium (Cd). Cd contamination increases the risk of diseases after consumption of grain crops with high Cd levels. Hyperaccumulators or accumulators have been widely used to bioremediate Cd‐contaminated farmland soil. Studies report that aquatic hyperaccumulators or accumulators are rarely used in phytoremediation, or their phytoremediation efficiencies are low. A pot experiment was carried out to explore the effects of abscisic acid (ABA) on the Cd accumulation (phytoremediation) of emerged aquatic accumulator plant Nasturtium officinale R. Br. Abscisic acid application increased the shoot biomass, peroxidase (POD) activity, superoxide dismutase (SOD) activity, catalase (CAT) activity, and soluble protein content of N. officinale under Cd‐contamination condition. The application of ABA at 5, 10, and 20 μmol/L increased the chlorophyll and carotenoid contents in N. officinale. The application of ABA also increased the shoot Cd content and shoot Cd extraction of N. officinale. The application of ABA at 1, 5, 10, and 20 μmol/L increased the shoot Cd extraction by 11.65%, 25.27%, 37.91%, and 58.52%, respectively, compared with the control. In addition, ABA concentration had a linear regression relationship with the root biomass, shoot biomass, root Cd extraction, and shoot Cd extraction. Correlation, gray relational, and path analyses showed that the root biomass, shoot biomass, root Cd extraction, root Cd content, POD activity, SOD activity, and soluble protein content were significantly associated with the shoot Cd extraction. These findings indicate that ABA application can improve the phytoremediation ability of N. officinale under Cd‐contaminated flooded fields.
Efficient adsorptive removal of two anionic dyes (methyl orange and methyl red) with MOF‐525: Adsorption isotherms and kinetics studies
Authors: Hu Wenbin , Yang Qiang , Wang Renjuan , Chen Qi , Kong Yun 
Published: December 2024

AbstractAdsorption is widely used to remove anionic and cationic dyes from wastewater because of its economical and high efficiency. Metal‐organic frameworks (MOFs), as a kind of adsorbent, have attracted great attention due to the large surface area, adjustable pore size, and high stability. In this study, a Zr‐MOF, named MOF‐525, was synthesized by using solvothermal method, and the adsorption performances of MOF‐525 on two anionic dyes (methyl orange, MO and methyl red, MR) were investigated. Results showed that the obtained MOF‐525, with the specific surface area of 2,613.91 m2 g−1, the total pore volume of 1.20 cm3 g−1, and the average pore size of 1.84 nm, exhibited high adsorption capacities for both MO and MR. The optimal pH value for MO and MR adsorption were 3.0 and 4.0, with the adsorption capacity of 854.30 and 629.67 mg g−1, respectively; in addition, the adsorption capacities for both MR and MO were increased with the increasing of SO42− concentration. The adsorption kinetics, isotherms, and thermodynamics results indicated the pseudo‐second‐order model and Langmuir (as well as Freundlich) could describe the adsorption processes of MOF‐525 well, and the adsorption processes for both MO and MR were spontaneous exothermic reactions. Besides, the reusability experiment demonstrated that MOF‐525 had significant adsorption capacity and good reusability for MR. In conclusion, the possible adsorption mechanisms of anionic dyes by MOF‐525 involved hydrogen bonding, electrostatic attraction, and π‐π interaction. These results illustrated that MOF‐525 might be a potential adsorption material for anionic dyes removal from wastewater.
Binge Eating Behaviour Before and 10 Years Following Metabolic and Bariatric Surgery
Authors: Reas Deborah Lynn , Lie Selma Øverland , Mala Tom , Lundin Kvalem Ingela 
Published: December 2024

ABSTRACTObjectiveLittle is known about the longer‐term maintenance, remission, or development of binge eating behaviour (BE) following metabolic and bariatric surgery (MBS). This brief report investigated BE prior to and 10 years following MBS and examined mental health and weight outcomes between BE groups (never BE, continued BE, remitted BE, or developed ‘de novo’ BE).MethodOne hundred and eighty‐three participants (76.1% females) with a mean age of 44.8 (± 9.5) years and mean BMI of 42.9 kg/m2 (± 5.4) were assessed before and 10 years following MBS (94.0% Roux‐n‐Y).ResultsAt 10 years, 48% had never engaged in BE, 27.9% had remitted, 15.8% had continued BE, and 8.2% reported de novo BE. Individuals who continued BE were younger, reported higher levels of anxiety and depression, and had regained more weight. Individuals who continued or developed de novo BE reported higher levels of post‐surgical repetitive eating behaviour and were more likely to regain ≥ 25% of maximum weight lost.ConclusionsApproximately 25% of the sample reported post‐operative BE a decade following MBS, including 8.2% de novo cases. Individuals who engaged in post‐operative BE demonstrated significantly worse mental health and weight outcomes, especially those with a lifetime history who continued to engage in BE after 10 years. Findings provide nuance to the existing literature and underscore the value of assessing BE at pre‐ and post‐surgery.
Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive Review
Authors: Kumar Ajay , Devi Reema , Dhalaria Rajni , Tapwal Ashwani , Verma Rachna , Rashid Summya , Elossaily Gehan M. , Khan Khalid Ali , Chen Kow‐Tong , Verma Tarun 
Published: December 2024

ABSTRACTMushrooms are considered as nutraceutical foods that can effectively prevent diseases such as cancer and other serious life‐threatening conditions include neurodegeneration, hypertension, diabetes, and hypercholesterolemia. The Cantharellus cibarius, also known as the “Golden chanterelle” or “Golden girolle,” is a significant wild edible ectomycorrhizal mushroom. It is renowned for its delicious, apricot‐like aroma and is highly valued in various culinary traditions worldwide. It is well known for its nutritional, nutraceutical, and therapeutic properties. The high nutritional value of C. cibarius is attributed to its abundant carbohydrates, proteins, β‐glucans, dietary fiber, and low‐fat content. It also contains medicinal polysaccharides (β‐glucans), proteins (lectins and selenoproteins), important fatty acids (linoleic and omega‐6), vitamins, and minerals (N, P, K, Ca, Zn, Ag, Se, etc.). The sporocarp of C. cibarius contains a diverse array of bioactive metabolites, including flavonoids, phenolics, sterols, fatty acids, organic acids, indole groups, carbohydrates, vitamins (tocopherols), amino acids, enzymes, bioelements, carotenoids, and 5ˊ‐nucleotides. C. cibarius has a wide array of biological properties, such as antioxidant, anticancer, anti‐inflammatory, antifungal, antibacterial, anthelmintic, insecticidal, antihypoxia, antihyperglycemic, wound‐healing, cytotoxic, and iron‐chelating activity. Thus, the present review gives an overview of C. cibarius, covering its chemical composition, ecological significance, postharvest preservation strategies, and potential applications in dietary supplements, nutraceuticals, and pharmaceuticals. It also dives into the etymology, taxonomy, and global distribution of the renowned “Golden Chanterelle.” Furthermore, there is a need to valorize waste materials created during production and processing, as well as to acquire a thorough understanding of the mechanisms of action of bioactive compounds in mushrooms.
Foreign competition and business diversification options
Authors: Drori Netanel , Andrews Daniel S. , Fainshmidt Stav , Xu Le 
Published: December 2024

AbstractResearch SummaryWe examine reallocation in a firm's business portfolio amid foreign competition in its primary business. We argue that firms will tend to exit unrelated industries and reallocate resources to related ones, reducing option breadth but increasing the value of narrower options due to synergies that contribute to building defensive moats against encroachment by foreign competition. This sequential process is strengthened among firms with greater absorptive capacity who are especially adept at identifying these changes and reallocation opportunities. Data on 2,582 US firms from 1997 to 2019 provide support for these arguments. Our study advances scholarly understanding of real options under uncertainty. It introduces the option of “flight to nearby places,” demonstrating how firms may seek to maintain competitiveness in the face of foreign competition.Managerial SummaryAs firms manage heightened foreign competition in their primary business, research suggests that reallocating resources within corporate portfolios is critical for maintaining competitiveness. In this context, we propose that firms are likely to streamline operations by exiting unrelated industries and reinforcing related ones. This move narrows options but can drive synergies and enhance the efficacy of defensive strategies against foreign competition. Data from 2,582 US firms provide insights for managers, emphasizing the importance of both option breadth and complementarity among options. Considering the challenges of managing increasingly competitive global markets, we show how firms may convert pressures into nearby opportunities to build defensive moats and maintain competitiveness.
Adenomyosis, especially in its focal nature, hampers implantation and live birth rate after single euploid embryo transfer
Authors: Trinchant Rafael , Cruz María , Requena Antonio , García‐Velasco Juan Antonio 
Published: December 2024

AbstractObjectiveThe primary objective of this study was to assess if uterine adenomyosis impacts live birth rate per euploid embryo transfer. The secondary objectives included addressing obstetric and perinatal outcomes in the study group.MethodsThis was a multicenter and retrospective cohort study in which 228 patients diagnosed with adenomyosis undergoing single euploid embryo transfer between 2016 and June 2023 were included and matched on 1:1 ratio to control patients without ultrasonographic diagnostic criteria for adenomyosis.ResultsA significant higher live birth rate per embryo transfer was observed in controls compared to women with adenomyosis: 107/228 (46.9%) versus 56/228 (24.6%), respectively (odds ratio (OR) = 2.71, 95% confidence interval [CI]: 1.73–4.13, p < 0.001). When dividing adenomyotic patients regarding the nature of the disease, a higher live birth rate per transfer was described in diffuse adenomyosis compared to focal adenomyosis: 47/166 (28.3%) versus 9/62 (15%), respectively (OR = 2.32, 95% CI: 1.03–5.78, p = 0.034). Described differences were constant even when correcting for multiple variables. There was no statistically significant difference in childbirth delivery method (vaginal vs. cesarean section) between the adenomyosis and control groups. Mean gestational age at the time of delivery, newborn size and weight, and incidences of low birth weight, preterm birth, and admission to the neonatal intensive care unit did not differ between the two groups. In addition, in vitro fertilization (IVF) and perinatal outcomes were similar in patients with diffuse compared with focal adenomyosis.ConclusionAdenomyosis, especially focal adenomyosis, affects clinical but may not affect perinatal outcomes after single euploid embryo transfer.
The impact of pharmacogenomics on a pharmacy and therapeutic committee's formulary system management: An opinion of the pharmacokinetics/pharmacodynamics/pharmacogenomics practice and Research Network for the American College of Clinical Pharmacy
Authors: Brown Jacob T. , Goldwire Miki , Massmann Amanda , Van Heukelom Joel , Pasternak Amy , Petry Natasha , Paetznick Courtney , Cavallari Larisa H. 
Published: December 2024

AbstractPharmacogenomic (PGx) considerations are increasingly influencing health system formularies, prompting Pharmacy and Therapeutics (P&T) committees to integrate genetic insights into their decision‐making processes. This can be the case in several clinical scenarios, including (1) Prioritizing the use of lower‐cost drugs, where PGx testing is applied to guide the use of lower‐cost medications when appropriate, (2) Rescuing medications that are effective in the majority of individuals but were removed from the formulary because of harm in a subset of individuals with a specific phenotype, (3) Improving medication safety by utilizing PGx testing/results to guide initiation of reduced drug doses or use of alternative therapy in patients with at‐risk genotypes, and (4) Restricting use of high‐cost drugs to individuals most likely to respond based on genotype. The primary objective of this PRN opinion piece is to describe how PGx impacts formulary management, including the challenges and opportunities that arise from precision medicine approaches to prescribing.
Intrauterine Testicular Torsion: Two Prenatally Diagnosed Cases and Review of the Literature
Authors: Lituania Mario , Sepulveda Waldo , Tonni Gabriele 
Published: December 2024

ABSTRACTThe third‐trimester ultrasound diagnosis in two fetuses with isolated testicular torsion is described. Pregnancy courses were uneventful and routine second‐trimester scans had shown no structural anomalies. Antenatal ultrasound performed at 32 + 3 and 33 + 0 weeks' gestation showed signs consistent with the diagnosis of isolated left spermatic cord torsion in both cases (absent flow across the testicular artery, hyperechogenic small rounded mass in the hemiscrotum representing the twisted testes, and hydrocele). Although testicular torsion may occasionally occur in utero, these acute events have been scanty reported in the prenatal literature. As a consequence of the ischemic injury, the rate of salvage of the affected testis is extremely low.
Environmental impacts of land application of biosolids to perennial pastures
Authors: Vieira‐Filho Leandro O. , Silveira Maria L. , Sanchez Joao M. D. , Kohmann Marta M. , Ricken Ester C. 
Published: December 2024

AbstractLand application of biosolids to pastures confers multiple agronomic and environmental benefits, particularly in coarse‐textured soils with low nutrient and organic matter levels. However, concerns over potential water quality have led to more stringent regulations that will limit beneficial reuse of biosolids in Florida. This 3‐year field study evaluated the impacts of biosolids application strategies on N and P leaching losses, and soil P availability in an established bahiagrass (Paspalum notatum Flueggé) pasture. Treatments consisted of 2 P sources (biosolids and inorganic fertilizer) applied at 0, 20, 40, and 60 kg total P ha−1. Inorganic fertilizer treatments received the same N loads as the corresponding biosolids treatments. Biosolids and inorganic fertilizer increased in situ soil P availability and pore‐water P concentrations relative to the control. Pore‐water P concentrations increased linearly with P rate with the greatest values generally associated with inorganic fertilizer. Relatively low leachate P concentrations (below the detection limit of 0.025 mg L−1 in 596 out of 777 samples) observed in the current study indicates minimum P offsite movement risk regardless of the P management strategy. Annual P mass leached was not affected by treatments; however, inorganic fertilizer resulted in modest but significant greater annual NO3‐N mass leached than the other treatments. Lack of biosolids application rate effect on P and N leaching losses indicates that reduction in biosolids imposed by new state regulation will likely have no positive impact on water quality. Data demonstrated that, when properly managed, biosolids can be an environmentally sound fertilizer source for pastures.
Deubiquitinases as novel therapeutic targets for diseases
Authors: Xian Yali , Ye Jing , Tang Yu , Zhang Nan , Peng Cheng , Huang Wei , He Gu 
Published: December 2024

AbstractDeubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ubiquitin ligases, finely balancing ubiquitination and deubiquitination processes to maintain cellular proteostasis and respond to various stimuli and stresses. Given their role in modulating ubiquitination levels of various substrates, DUBs are increasingly linked to human health and disease. Here, we review the DUB family, highlighting their distinctive structural characteristics and chain‐type specificities. We show that DUB family members regulate key signaling pathways, such as NF‐κB, PI3K/Akt/mTOR, and MAPK, and play crucial roles in tumorigenesis and other diseases (neurodegenerative disorders, cardiovascular diseases, inflammatory disorders, and developmental diseases), making them promising therapeutic targets Our review also discusses the challenges in developing DUB inhibitors and underscores the critical role of the DUBs in cellular signaling and cancer. This comprehensive analysis enhances our understanding of the complex biological functions of the DUBs and underscores their therapeutic potential.