bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bias‐corrected meta‐analysis model for combining, studies of different types and quality
Authors: Verde Pablo Emilio 
Published: September 2020

AbstractPublic health researchers may have to decide whether to perform a meta‐analysis including only high‐quality randomized clinical trials (RCTs) or whether to include a mixture of all the available evidence, namely RCTs of varying quality and observational studies (OS). The main hurdle when combining disparate evidence in a meta‐analysis is that we are not only combining results of interest but we are also combining multiple biases. Therefore, commonly applied meta‐analysis methods may lead to misleading conclusions.In this paper, we present a new Bayesian hierarchical model, called the bias‐corrected (BC) meta‐analysis model, to combine different study types in meta‐analysis. This model is based on a mixture of two random effects distributions, where the first component corresponds to the model of interest and the second component to the hidden bias structure. In this way, the resulting model of interest is adjusted by the internal validity bias of the studies included in a systematic review.We illustrate the BC model with two meta‐analyses: The first one combines RCTs and OS to assess effectiveness of vaccination to prevent invasive pneumococcal disease. The second one investigates the effectiveness of stem cell treatment in heart disease patients. Our results show that ignoring internal validity bias in a meta‐analysis may lead to misleading conclusions. However, if a meta‐analysis model contemplates a bias adjustment, then RCTs results may increase their precision by including OS in the analysis. The BC model has been implemented in JAGS and R, which facilitate its application in practice.
Assessment of the in vivo biofunctionality of a biomimetic hybrid scaffold for osteochondral tissue regeneration
Authors: Tschon Matilde , Brogini Silvia , Parrilli Annapaola , Bertoldi Serena , Silini Antonietta , Parolini Ornella , Faré Silvia , Martini Lucia , Veronesi Francesca , Fini Milena , Giavaresi Gianluca 
Published: September 2020

AbstractChondral and osteochondral lesions represent one of the most challenging problems in the orthopedic field, as these types of injuries lead to disability and worsened quality of life for patients and have an economic impact on the healthcare system. The aim of this in vivo study was to develop a new tissue engineering approach through a hybrid scaffold for osteochondral tissue regeneration made of porous polyurethane foam (PU) coated under vacuum with calcium phosphates (PU/VAC). Scaffold characterization showed a highly porous and interconnected structure. Human amniotic mesenchymal stromal cells (hAMSCs) were loaded into scaffolds using pectin (PECT) as a carrier. Osteochondral defects in medial femoral condyles of rabbits were created and randomly allocated in one of the following groups: plain scaffold (PU/VAC), scaffold with hAMSCs injected in the implant site (PU/VAC/hAMSC), scaffold with hAMSCs loaded in pectin (PU/VAC/PECT/hAMSC), and no treated defects (untreated). The therapeutic efficacy was assessed by macroscopic, histological, histomorphometric, microtomographic, and ultrastructural analyses at 3, 6, 12, and 24 weeks. Histological results showed that the scaffold was permissive to tissue growth and penetration, an immature osteocartilaginous tissue was observed at early experimental times, with a more accentuated bone regeneration in comparison with the cartilage layer in the absence of any inflammatory reaction.
Reducing nihilism in metastatic pancreatic ductal adenocarcinoma: Treatment, sequencing, and effects on survival outcomes
Authors: O'Reilly Eileen M. , Cockrum Paul , Surinach Andy , Wu Zheng , Dillon Allison , Yu Kenneth H. 
Published: September 2020

ABSTRACTBackgroundReal‐world practice patterns, treatment sequencing, and outcomes in patients with metastatic pancreatic cancer remain unclear. Previous research indicates that the likelihood of patients with metastatic pancreatic cancer receiving or continuing cancer‐directed therapy is low—a phenomenon called nihilism. This retrospective, descriptive analysis examined clinical characteristics, treatment patterns, and outcomes for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).MethodsTreatment patterns were examined using electronic health records from the Flatiron Health database covering the period from January 1, 2014, to June 30, 2019. Real‐world overall survival [rwOS]) was compared for a subgroup of patients receiving treatment and a matched subgroup not receiving treatment.ResultsOf 7666 patients, 5687 (74.2%) received at least one line of systemic therapy. A greater proportion of patients receiving treatment than not receiving treatment had an initial diagnosis of stage IV disease (68.8% vs 61.2%, respectively). Among patients receiving an initial therapy, fewer than half (38.2%; 2174/5687) received second‐line treatment, mostly because they died, and only 34.3% (745/2174) of those receiving second‐line treatment advanced to third‐line treatment. The rwOS for patients receiving at least one line of systemic therapy was 8.1 months versus 2.6 months for matched patients not receiving treatment (hazard ratio, 0.41; 95% confidence interval, 0.38‐0.45; 1470 patients per group).ConclusionsSystemic therapy provided significant clinical benefit for patients who were eligible and chose to receive it, particularly when treatment was consistent with guideline recommendations. The large proportion of patients initiating treatment suggests that nihilism with mPDAC is diminishing.
Self‐brand connection and intention to purchase a counterfeit luxury brand in emerging economies
Authors: Chand Vijay Shankar , Fei Chen 
Published: September 2020

AbstractOnly a few studies have examined the relationship between consumers' self–brand connection and the intention to purchase counterfeit luxury brands in emerging economies. The current research explores the decision taken by consumers who are self‐connected to a brand to purchase counterfeit luxury brands. A survey‐based study was conducted among potential counterfeit buyers in nine malls in three cities in China. A sample of shoppers who physically shop in malls (n = 1,230) was used to test the hypotheses by using the structural equation model. Conspicuous consumption and emotional attachment were examined as mediators between self–brand connection and intention to purchase a counterfeit luxury brand. Creatively, this research used perceived counterfeit detection to determine how important people reflect their decision to purchase counterfeit luxury brands. The study also tests the moderation effect of economic benefit in the relationship between self–brand connection and counterfeit luxury brand purchase. Results demonstrate that consumers who are eager to build their self‐concept may decide to purchase counterfeit luxury brands. The mediation results show that conspicuous consumption and emotional attachment mediate the relationship. Interestingly, because of the involvement of perceived counterfeit detection, the effect is greater than the effect before mediation. Moreover, the economic benefit was found to increase the desire for counterfeit luxury brand purchases in emerging markets. The implication for managers is to customize the marketing campaigns that match the environment where the problem persists in reducing the consumer desire on counterfeit luxury brands and enhance the desire for the original luxury brand.
Bimetallic‐organic Frameworks CoMo‐ZIF‐67: An Efficient and Stable Catalyst for Selective Oxidation of Alkenes
Authors: Zou Wenhong , Guo Yingxiong , Li Pan , Liu Mengying , Hou Linxi 
Published: September 2020

AbstractDeveloping catalysts for the selective oxidation of alkenes with environment‐friendly, unique structural characteristics, high economic benefit and better catalytic performance is important. Herein, we employed ZIF‐67 as the sacrificial template to synthesize bimetallic‐organic frameworks CoxMo100‐x‐ZIF nanocages by a facile dissolution‐regrowth strategy. The Co51.8Mo48.2‐ZIF catalyst was tested under various experimental parameters for the selective oxidation of cyclooctene to screen the optimal reaction conditions. Under the optimal reaction conditions, Co51.8Mo48.2‐ZIF nanocages exhibited a high cyclooctene conversion of 99.3 % and a selectivity of 99.0 % to epoxy cyclooctane. Furthermore, Co51.8Mo48.2‐ZIF nanocages can maintain their catalytic performance after reused five catalytic cycles. This bimetallic catalyst could also be used for the epoxidation of a wide range of alkenes, such as hexene or cyclohexene. In addition, the kinetic studies were conducted, and a reasonable reaction mechanism was proposed based on density functional theory calculations. The outstanding catalytic performance of CoxMo100‐x‐ZIF nanocages can be attributed to the cooperativity between Co and Mo sites and the hollow structure with high surface areas.
Evaluation of circulating tumor cell clusters for pan‐cancer noninvasive diagnostic triaging
Authors: Gaya Andrew , Crook Timothy , Plowman Nicholas , Ranade Anantbhushan , Limaye Sewanti , Bhatt Amit , Page Raymond , Patil Revati , Fulmali Pradip , Datta Vineet , Kumar Prashant , Patil Darshana , Akolkar Dadasaheb 
Published: September 2020

BackgroundHistopathologic examination (HPE) of tumor tissue obtained by invasive biopsy is the standard for cancer diagnosis but is resource‐intensive and has been associated with procedural risks. The authors demonstrate that immunocytochemistry (ICC) profiling of circulating ensembles of tumor‐associated cells (C‐ETACs) can noninvasively provide diagnostic guidance in solid organ cancers.MethodsThe clinical performance of this approach was tested on blood samples from 30,060 individuals, including 9416 individuals with known cancer; 6725 symptomatic individuals with suspected cancer; and 13,919 asymptomatic individuals with no prior diagnosis of cancer. C‐ETACs were harvested from peripheral blood and profiled by ICC for organ‐specific and subtype‐specific markers relevant to the cancer type. ICC profiles were compared with HPE diagnoses to determine concordance.ResultsThe presence of malignancy was confirmed by the detection of C‐ETACs in 91.8% of the 9416 individuals with previously known cancer. Of the 6725 symptomatic individuals, 6025 were diagnosed with cancer, and 700 were diagnosed with benign conditions; C‐ETACs were detected in 92.6% of samples from the 6025 individuals with cancer. In a subset of 3509 samples, ICC profiling of C‐ETACs for organ‐specific and subtype‐specific markers was concordant with HPE findings in 93.1% of cases. C‐ETACs were undetectable in 95% of samples from the 700 symptomatic individuals who had benign conditions and in 96.3% of samples from the 13,919 asymptomatic individuals.ConclusionsC‐ETACs were ubiquitous (>90%) in various cancers and provided diagnostically relevant information in the majority (>90%) of cases. This is the first comprehensive report on the feasibility of ICC profiling of C‐ETACs to provide pan‐cancer diagnostic guidance with accuracy comparable to that of HPE.
Highly collaborative distributed systems: Synthesis and enactment at work
Authors: Autili Marco , Perucci Alexander , Leite Leonardo , Tivoli Massimo , Kon Fabio , Di Salle Amleto 
Published: September 2020

SummaryService choreographies support a distributed composition approach that is based on the specification of the external interaction of the participant services in terms of flows of message exchanges, given from a global perspective. When developing distributed service‐based applications, different services are produced by different teams; at the same time, such choreographies can also interact with third‐party services, hence leading to the reuse of black‐box services. Enforcing a global coordination logic across the many in‐house and third‐party services to correctly realize the specified choreography is a nontrivial endeavor. Automatic support is then desirable. In this article, we present an integrated development and run‐time environment for choreography‐based systems, which covers all the development activities, including specification, code synthesis, automatic deployment, enactment, and monitoring on the Cloud. We focus on providing a practical solution, that is, applicable by the community and considering technological standards used in the industry. We report the results of an experiment that we conducted with a use case in the in‐store marketing and sales domain. Results confirm confidence in the approach and show that the platform can be applied in practical contexts.
Homoeology of Thinopyrum distichum single‐chromosome additions in triticale and wheat
Authors: Marais Gideon Francois , Fiedler Jason , Tao Hongbin , Pirseyedi Seyed , Hegstad Justin , Ganaparthi Venkata , Liu Yuan , Bisek Bradley , Li Xuehui 
Published: September 2020

AbstractThinopyrum distichum (Thunb.) Á. Löve (2n = 4x = 28; J1dJ1dJ2dJ2d) inhabits harsh, dry saline coastal dunes. Its adaptive genes can be of value to cultivated cereals; therefore, single‐chromosome additions were previously developed in hexaploid triticale (×Triticosecale Wittm. ex A. Camus) and common wheat (Triticum aestivum L.); however, their homoeology to triticale and wheat chromosomes remained largely unknown. Here we used genotyping‐by‐sequencing (GBS) to supplement conventional markers and determine the synteny of the Th. distichum addition chromosomes. Twenty‐seven triticale lines with single Th. distichum addition chromosomes were analyzed. Genotyping‐by‐sequencing yielded 2.75 million unique sequences that included 134,506 Th. distichum‐specific tags absent in the wheat, durum wheat [Triticum turgidum L. subsp. Durum (Desf.) van Slageren], ×Triticosecale spp., and rye (Secale cereale L.) controls. The Th. distichum‐specific tags were then sorted into 125,262 informative, single‐pair tags (from one homoeologous group) and 9,244 uninformative, multi‐group tags associated with more than one homoeologous group. Presence–absence patterns produced by the single‐pair tags suggested the presence of 11 different Th. distichum addition chromosomes whose associated sequence tags were then aligned to the Th. elongatum (Host) D. R. Dewey and Chinese Spring (CS) genomic databases to reveal their homoeology. Five prominent translocations were detected among the 11 Th. distichum addition chromosomes and three chromosomes appeared to be extensively restructured. The extra chromosomes in 10 additions to common wheat represented five different Th. distichum chromosomes that were also represented in the triticale set. The 11 distinct Th. distichum addition chromosomes constitute a useful genetic resource for continued dissection of the Th. distichum genomes.
TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system
Authors: Gobert Delphine , Schohl Anne , Kutsarova Elena , Ruthazer Edward S. 
Published: September 2020

AbstractNewly synthesized proteins support the development of functional neural circuits and previous work has suggested that dysregulated translation mediates certain forms of autism spectrum disorder (ASD). Here, we investigated the role of Target of Rapamycin Complex 1 (TORC1) in synaptic and dendritic development in vivo in the retinotectal system of Xenopus laevis tadpoles. We found that TORC1 signaling regulates dendritic growth and branching and that acute over‐activation of TORC1 by Rheb overexpression drove enhanced maturation of excitatory synapses by recruiting AMPA receptors. Interestingly, TORC1 over‐activation did not affect inhibitory transmission, resulting in a significant imbalance in the excitatory‐to‐inhibitory ratio. Rheb overexpression also enlarged excitatory visual input fields in tectal neurons, consistent with dysregulation of retinotopic input refinement and integration of the cell into the circuit. In contrast to other reports that mainly found impairments in synaptic inhibition using broad systemic deletion or mutation of TORC1 regulatory proteins, our findings from acute, local manipulation of TORC1 reveal its critical role in selectively regulating the number and maturity of excitatory, but not inhibitory, synapses in the developing brain.
Past, current, and potential future distributions of unique genetic diversity in a cold‐adapted mountain butterfly
Authors: Minter Melissa , Dasmahapatra Kanchon K. , Thomas Chris D. , Morecroft Mike D. , Tonhasca Athayde , Schmitt Thomas , Siozios Stefanos , Hill Jane K. 
Published: September 2020

AbstractAimClimatic changes throughout the Pleistocene have strongly modified species distributions. We examine how these range shifts have affected the genetic diversity of a montane butterfly species and whether the genetic diversity in the extant populations is threatened by future climate change.LocationEurope.TaxonErebia epiphron Lepidoptera: Nymphalidae.MethodsWe analyzed mtDNA to map current genetic diversity and differentiation of E. epiphron across Europe to identify population refugia and postglacial range shifts. We used species distribution modeling (SDM) to hindcast distributions over the last 21,000 years to identify source locations of extant populations and to project distributions into the future (2070) to predict potential losses in genetic diversity.ResultsWe found substantial genetic diversity unique to specific regions within Europe (total number of haplotypes = 31, number of unique haplotypes = 27, Hd = 0.9). Genetic data and SDM hindcasting suggest long‐term separation and survival of discrete populations. Particularly, high rates of unique diversity in postglacially colonized sites in England (Hd = 0.64) suggest this population was colonized from a now extinct cryptic refugium. Under future climate change, SDMs predict loss of climate suitability for E. epiphron, particularly at lower elevations (<1,000 meters above sea level) equating to 1 to 12 unique haplotypes being at risk under climate scenarios projecting 1°C and 2–3°C increases respectfully in global temperature by 2070.Main conclusionsOur results suggest that historical range expansion and retraction processes by a cold‐adapted mountain species caused diversification between populations, resulting in unique genetic diversity which may be at risk if distributions of cold‐adapted species shrink in future. Assisted colonizations of individuals from at‐risk populations into climatically suitable unoccupied habitat might help conserve unique genetic diversity, and translocations into remaining populations might increase their genetic diversity and hence their ability to adapt to future climate change.
Ecohydrological controls on lichen and moss CO2 exchange in rock barrens turtle nesting habitat
Authors: Hudson Danielle T. , Markle Chantel E. , Harris Lorna I. , Moore Paul A. , Waddington James M. 
Published: September 2020

AbstractLichens and mosses are among the first organisms to colonize the open bedrock of eastern Georgian Bay, Ontario making them essential for primary soil formation and ecosystem succession, while also providing nesting habitat for turtle species‐at‐risk. However, the slow growing nature of lichen and moss makes them vulnerable to ecohydrological stresses caused by climate and land‐use change. In order to better understand how lichen and moss will respond to stressors, we examined which ecohydrological factors (e.g., near‐surface soil moisture and temperature) control the CO2 exchange of lichen (Cladonia spp.) and moss (Polytrichum spp.) on rock barrens, and the time of year growth primarily occurs. Net ecosystem productivity (NEP) was significantly greater in the wet period of the growing season than the dry, with an estimated difference of 0.7 μmol m−2 s−1 for lichen, 2.9 μmol m−2 s−1 for moss, and 2.5 μmol m−2 s−1 for a moss and lichen mix. These findings indicate that the wet portions of the growing season are critical for growth, while lichen and moss have little to no productivity during the dry period. Our results indicate that near‐surface soil moisture is an indicator of the CO2 exchange of lichen and moss, and this relationship varies among cover types. For the geographical regions where warm, dry conditions are expected to increase in duration and frequency with climate change, lichen and moss NEP will likely decrease, thus limiting the long‐term availability of nesting habitat for turtle species‐at‐risk.
Effects of the Neonicotinoid Acetamiprid in Pollen on Bombus impatiens Microcolony Development
Authors: Camp Allison A. , Batres Michael A. , Williams Wanda C. , Koethe Robert W. , Stoner Kimberly A. , Lehmann David M. 
Published: September 2020

Abstract
Honey bees and other wild bee species including bumble bees have experienced population declines in recent decades. Although many stressors are implicated in bee population declines, much attention has focused on neonicotinoid pesticides, which are widely used and known to be toxic to pollinators. One neonicotinoid, acetamiprid, has been studied very little in bumble bees, despite its use on bumble bee–pollinated crops. We assessed the impacts of acetamiprid to the North American bumble bee Bombus impatiens using the microcolony model. We examined nest growth, development, and subsequent nest productivity as measured by drone production. We found that high concentrations of acetamiprid in pollen (4520 µg/kg) significantly impacted nest growth, development, and, ultimately, reproduction (drone production). We found the no-observable–adverse effect level to be 45.2 µg/kg. Overall, acetamiprid has the potential to negatively impact reproductive endpoints for B. impatiens. However, effects occurred at concentrations substantially higher than expected environmental concentrations that would be achieved when following label rates. Further work is required to assess the effects of this pesticide on B. impatiens via alternate routes of exposure and on queenright colonies. Environ Toxicol Chem 2020;39:2560–2569. © 2020 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Fault Detection and Isolation for Proton Exchange Membrane Fuel Cell Using Impedance Measurements and Multiphysics Modeling
Authors: Jullian G. , Cadet C. , Rosini S. , Gérard M. , Heiries V. , Bérenguer C. 
Published: September 2020

AbstractThis study proposes a fault detection and isolation tool for proton exchange membrane fuel cell (PEMFC) operating in embedded applications. A model‐based approach, taking partially into account degradation phenomena, is proposed in order to increase the robustness of the tool regarding transient operations and stack ageing. The considered faults are the abnormal operating conditions that can decrease the fuel cell lifetime. The fault detection approach is based on residual generation using both voltage and high frequency resistance measurements and thus combining the advantages of knowledge‐based model and electrochemical impedance spectroscopy (EIS) diagnosis approaches. To that end, a multi‐physics fuel cell model has been used. This model computes not only the stack voltage but also the high frequency resistance in dynamic conditions. Additionally, the model is modified to take into account the ageing of the fuel cell. Validation is carried out on experimental characterizations during 1,000 h ageing. The results on a new fuel cell stack show a score of 91% for fault isolation. However, without any adaptation, this score drops dramatically as the stack ages. Finally, thanks to ageing modeling and to the proposed adaptation of the detection/isolation procedure, the diagnosis performance remains reliable during fuel cell stack ageing.