bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proton Pump Inhibitor Taking Associates with Higher All-Cause Mortality and CV Events in Peritoneal Dialysis Patients
Authors: Zeng Yingsi , Liu Lingling , Zhu Liya , Zhan Xiaojiang , Peng Fenfen , Feng Xiaoran , Zhou Qian , Zhang Yujing , Wang Zebin , Liang Jianbo , Li Jiao , Wen Yueqiang 
Published: December 2020

Abstract
Background: A long period of inappropriate proton pump inhibitors (PPI) treatment have been proved to be associated with adverse prognosis in general population and hemodialysis (HD) patients. This study was conducted to clarify the impact of PPI taking on mortality and adverse cardiovascular (CV) events in peritoneal dialysis (PD) patients.Methods: This is a retrospective study. We enrolled 904 patients from two PD centers, included 211 patients on PPI treatment and 618 patients not taking PPIs. Kaplan-Meier curves were used to identify the incidence of adverse outcomes. Multivariate Cox regression models and inverse probability of treatment weighting (IPTW) were applied to analyze hazard ratios (HRs) for adverse outcomes. Results: During follow-up, 162 deaths and 102 CV events were recorded. Kaplan-Meier curve demonstrated all-cause mortality (log-rank test P=0.018) and CV events (log-rank test P=0.024) were significantly higher in PPI usage group. Multivariate COX regression models and IPTW showed that PPI taking was an indicator for all-cause mortality (HR=1.33, 95%CI=1.07-1.65, P=0.010) and CV events (HR=1.81, 95%CI=1.38-2.38, P<0.001). Conclusions: PPI usage associates with higher all-cause mortality and CV events in PD patients. Clinicians are supposed to be more careful when using PPI and need to master the indications more rigorously in patients receiving PD treatment.
LncRNA AC245100.4 affects the tumorigenesis of prostate cancer via regulating the STAT3/NR4A3 axis
Authors: Liu Chi , Lin Ping , Zhao Jiabin , Xie Hui , Zheng Tianhu , Li Rou , Wang Nan , Jia Huizhen , Yang Xu , Jiang Shan , Qi Qi , Yu Xiaoguang 
Published: December 2020

Abstract
Background

Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of cancer deaths among men globally. However, the molecular mechanisms leading to the progression have not been fully elucidated.
Methods

The expression and location of AC245100.4 were examined by RT-qPCR and nuclear-cytoplasmic separation assay. RNA-seq analysis was performed to identify the downstream of AC245100.4. RNA immunoprecipitation was performed to identify the proteins those bind to AC245100.4. Western blotting was performed to quantify the expression of proteins. Finally, a series of gain- or loss-functional assays were done to prove the precise role of AC245100.4 and NR4A3 in PCa.
Results

We identify a critical lncRNA AC245100.4, which is significantly up-regulated in prostate cancer tissues and cells. Knockdown of AC21500.4 can significantly inhibit prostate cancer progression in vitro and in vivo. Further RNA-seq analysis shows that NR4A3 may be the potential target of AC245100.4. Mechanistically, AC245100.4 de-regulates NR4A3 transcriptionally via increasing p-STAT3, which is a transcriptional repressor of NR4A3.
Conclusion

Our results demonstrated that AC245100.4 was a critically oncogenic lncRNA in PCa via inhibiting NR4A3 and paved a promising avenue to combat PCa progression by targeting AC245100.4 or NR4A3.
The Sex Difference and Potential Influence Factors In 96,237 Patients With Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis
Authors: Ma Lingwei , Lu Huan , Wu Meng , Xue Liru , Zhu QingQing , Zhang Jinjin , Wang Shixuan 
Published: December 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease was first identified in December 2019 in Wuhan and has since spread globally, resulting in the ongoing 2019–20 coronavirus pandemic. Numerous studies of the clinical characteristics of patients with SARS-CoV-2 have been reported, yet yielded varying results given the sex difference of prevalence, severity and fatality rate. We conducted a review and meta-analysis of the sex differences of COVID-19, aiming to reveal the epidemiological characteristics and potential influencing factors of COVID-19 and provide reference for the prevention and treatment of patients.Results: By screening 1436 studies, 156 studies including 96237 COVID-19 patients from multiple countries were included. We found out that females account for 0.47 [95% CI (0.45-0.48)] of the diagnosed COVID-19 cases, while males for 0.53 of the cases [95% CI (0.52-0.55)]. Females admitted into intensive care unit (ICU) or with severe/critical illness were also analyzed, and the ratio was 0.14 [95% CI (0.11-0.17)] among all the severely/critically ill patients, which was almost twice lower than the ratio of males (0.24 [95% CI (0.19-0.29)]). The fatality rate of female patients was 0.10 [95%CI (0.05-0.17)], which was much lower than that of males (0.18[95%CI (0.11-0.29)]).Conclusions: There exists a significantly different clinical outcome between male and female COVID-19 patients. Females are less severely affected, which might be associated with the sex-based difference in immune response, female hormones and behaviors. However, more specific studies are needed to identify more relevant factors.
Patrimonio documental: memoria y futuro del Archivo de Arquitectos Mexicanos
Authors: González Franco Lourdes Cruz , Drago Quaglia Elisa , Hernández Sánchez María Eugenia 
Published: December 2020

<p class="p1">El presente texto explora la importancia del Archivo de Arquitectos Mexicanos (AAM) de la Facultad de Arquitectura de la UNAM, que cuenta con 27 fondos documentales de arquitectos cuya obra es representativa del movimiento moderno en México. Dentro de sus instalaciones se concentran soportes documentales diversos que constituyen fuentes primarias esenciales para nuevas interpretaciones de los fenómenos históricos, arquitectónicos, urbanos y culturales.<span class="Apple-converted-space"> </span></p>
Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes
Authors: Kanapka Lauren G. , Wadwa R. Paul , Breton Marc D. , Ruedy Katrina J. , Ekhlaspour Laya , Forlenza Gregory P. , Cengiz Eda , Schoelwer Melissa J. , Jost Emily , Carria Lori , Emory Emma , Hsu Liana J. , Weinzimer Stuart A. , DeBoer Mark D. , Buckingham Bruce A. , Oliveri Mary , Kollman Craig , Dokken Betsy B. , Cherñavvsky Daniel , Beck Roy W. 
Published: December 2020

OBJECTIVETo further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes.RESEARCH DESIGN AND METHODSAfter a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented pump (SAP) therapy in 101 children 6–13 years old with type 1 diabetes, 22 participants in the SAP group initiated use of the CLC system (referred to as SAP-CLC cohort), and 78 participants in the CLC group continued use of CLC (CLC-CLC cohort) for 12 weeks.RESULTSIn the SAP-CLC cohort, mean percentage of time in range 70–180 mg/dL (TIR) increased from 55 ± 13% using SAP during the RCT to 65 ± 10% using CLC (P &lt; 0.001), with 36% of the cohort achieving TIR &gt;70% plus time &lt;54 mg/dL &lt;1% compared with 14% when using SAP (P = 0.03). Substantial improvement in TIR was seen after the 1st day of CLC. Time &lt;70 mg/dL decreased from 1.80% to 1.34% (P &lt; 0.001). In the CLC-CLC cohort, mean TIR increased from 53 ± 17% prerandomization to 67 ± 10% during the RCT and remained reasonably stable at 66 ± 10% through the 12 weeks post-RCT. No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either cohort.CONCLUSIONSThis further evaluation of the Control-IQ CLC system supports the findings of the preceding RCT that use of a closed-loop system can safely improve glycemic control in children 6–13 years old with type 1 diabetes from the 1st day of use and demonstrates that these improvements can be sustained through 28 weeks of use.
Percursos Formativos no Campo da Extensão: obra cinematográfica como dispositivo para o diálogo
Authors: De Oliveira Everton Ferrer , Parise Moscato Jarbas , Da Costa de Oliveira Helena Beatriz , Bianchi Paula 
Published: December 2020

Este trabalho faz a análise de uma atividade cinematográfica realizada no projeto de extensão Percursos Formativos no Campo da Extensão, proposto pelo Curso de Pedagogia, realizado no ano de 2017 na Universidade Federal do Pampa, Campus Jaguarão-RS-Brasil. A proposta da atividade foi feita pelo Programa de Educação Tutorial (PET) do Curso de Bacharelado em Produção e Política Cultural direcionado para os participantes de todos os cursos do Campus Jaguarão da UNIPAMPA e comunidade em geral. Os objetivos do projeto eram ampliar o contato e a prática da extensão universitária e com isso a inserção regional, para tanto foram convidados extensionistas de diferentes áreas. Neste trabalho analisamos a atividade por meio de trinta formulários de avaliação da atividade desenvolvida no projeto de extensão, pano de fundo e cenário dedicados à vivência dos participantes do projeto. Como discussões ressaltamos a proposta e a forma pedagógica instigante trazidas na atividade cinematográfica. Proporcionou-se olhar, escuta e interação no diálogo sobre o processo vivido pelos participantes de diferentes cursos. Como considerações finais destacamos que a atividade orientada pela arte do cinema possibilita abertura às inovações, tentativas de ampliação do leque para reflexões e observações da realidade e com isso problematizar tanto o dialogo proporcionado pela atividade cinematográfica. Que motivou o debate entre os participantes envolvidos no referido projeto quanto a reflexão acadêmica pautada no cinema.
Strategies for posterior-only minimally invasive surgery in thoracolumbar metastatic epidural spinal cord compression
Authors: Alshareef Mohammed Abdul , Klapthor Gibson , Lowe Stephen R. , Barley Jessica , Cachia David , Frankel Bruce M. 
Published: December 2020

Background:
Metastatic epidural spinal cord compression (MESCC) is a debilitating sequela of cancer. Here, we evaluated various subtypes of posterior-only minimally invasive spinal (MIS) procedures utilized to address different cancers.

Methods:
Within this retrospective review, we analyzed the treatment of thoracolumbar MESCC treated with three MIS techniques: decompression and fusion (Subgroup A), partial corpectomy (Subgroup B), and full corpectomy (Subgroup C).

Results:
There were 51 patients included in the study; they averaged 58.7 years of age, and 51% were females. Most tumors were in the thoracic spine (51%). The average preoperative Frankel grade was D (62.7%); 69% (35) improved postoperatively. The patients were divided as follows: subgroup A (15 patients = 29.4%), B (19 patients = 37.3%), and C (17 patients = 33.3%). The length of hospitalization was similar (~5.4 days) for all groups. The overall complication rate was 31%, while blood loss was lower in Subgroups A and B versus C.

Conclusion:
Different MIS surgical techniques were utilized in patients with thoracic and/or lumbar MESCC. Interestingly, clinical outcomes were similar between MIS subgroups, in this study, with a trend toward higher complications and greater blood loss associated with those undergoing more aggressive MIS procedures (e.g., full corpectomy and fusion).
PROPERTY INTEREST IN MAINTENANCE OBLIGATIONS: ON THE SCOPE OF ARTICLE 86 FAMILY CODE OF THE RUSSIAN FEDERATION
Authors: Беспалов Юрий Федорович 
Published: December 2020

В данном научном труде представлен подход автора к пониманию существа интереса и пределов его действия в алиментных обязательствах родителей и детей, связанных с участием родителей в дополнительных расходах на содержание ребенка, которые вызваны исключительными обстоятельствами. Сделан вывод о том, что дополнительная забота родителей о ребенке возникает на основании нескольких взаимосвязанных между собой обстоятельств: родственной связи; трудной жизненной ситуации, в которой оказался ребенок; отношений по содержанию; неурегулированности разногласий между родителями; наличия объективной связи исключительных обстоятельств с расходами; имущественного интереса родителей и ребенка. Предложено изменить редакцию ст. 86 СК РФ с целью соответствия содержащихся в ней положений интересам родителей и ребенка, характеризующихся их гармоничным сочетанием.
This scientific work presents the author’s approach to understanding the essence of interest and the extent of its action in the alimony obligations of parents and children associated with the participation of parents in additional costs for the maintenance of a child, which are caused by exceptional circumstances. It is concluded that additional parental care for the child arises on the basis of several interrelated circumstances: kinship; difficult life situations in which the child finds himself; content relationships; unresolved disagreements between parents; the existence of an objective connection of exceptional circumstances with costs; property interests of parents and the child. It is proposed to change the wording of Art. 86 of the IC of the Russian Federation in order to comply with the provisions contained in it with the interests of parents and the child, characterized by their harmonious combination.
Pengembangan Pengembangan wisata pantai di Kabupaten Buton Tengah: (Studi pada Mutiara, Wantopi, dan Katembe)Development of coastal tourism in Central Buton Regency: (St
Authors: La Bonto Ahmad Zulkivar , Rofiaty Roafiaty , Susilowati Christin 
Published: December 2020

Tujuan penelitian ini untuk mengeksplorasi permasalahan dan menemukan strategi pengembangan wisata pantai di Buton Tengah, yaitu wisata pantai Mutiara yang berada di desa Gumanano, wisata pantai Wantopi yang berada di desa Wantopi, dan wisata pantai Katembe yang berada di desa Madongka.Jenis penelitian ini adalah kualitatif dengan pendekatan studi kasus.Informan penelitian adalah sepuluh orang perwakilan dari stakeholder wisata pantai pada masing-masing destinasi wisata tersebut, yang terdiri dari Dinas Kepemudaan dan Pariwisata Kabupaten Buton Tengah, Kepala Desa masing-masing desa, masyarakat dan wisatawan masing-masing tempat wisata tersebut. Hasil penelitia mengungkapkan bahwa dengan sumber daya yang mendukung yaitu terdapat sumber daya alami dan pendukung sebagai produk utama dan pendukung wisata, namun terdapat permasalah pada pengelolaan pariwisata tersebut. Permasalah yang ditemukan antara lain kurang faktor pendung pariwisata, manjaemen destinasi dan destinasi manajemen organisasi yang tidak terorganisir denganbaik, tidak dilibatkan dan kurangnya partisipasi stakeholder lain dalam proses pengelolaan pariwisata, dan tidak ada jaminan atas keamanan dan keselamatan bagi wisatawan yang diakibatkan belum terciptanya PERDA yang mengatur tentang pengelolaan pariwisata. Dari permasalahan tersebut ditemukan strategi dalam pengelolaan pariwisata di antaranya dilakukan pelatihan terhadap kelompok stakeholder, menciptakan regulasi dan melibatkan semua stakeholder dalam pengelolaan pariwisata, serta segera dikeluarkan PERDA yang mengatur mengenai pengelolaan pariwisata di Kabupaten Buton Tengah.
SIMILE USED IN LENKA’S SONG EVERYTHING AT ONCE
Authors: Syarifah Syarifah , Manugeren M. , Purwarno Purwarno 
Published: December 2020

The research was related to figurative language but the researchers focused on simile, aimed at identifying the dominant type of simile used based on the theory put forward by Kennedy and Giola. Simile is a comparison of one thing to another which is always listed because the words "like" or as are used. Simile is also commonly used in song lyrics and this is referred to as the object of the research, that is the song lyrics taken by Lenka’s song Everything at Once. The researchers take this song because all the lyrics are full of similes, from the beginning to the end of the song. Qualitative content analysis as the use of replicable and valid methods to make specific inferences from the text to other circumstances or properties of the source under the Descriptive Qualitative Approach, pioneered by Krippendorff is applied here. The results show that there are two types of simile in this song and the dominant types used in this song is close simile.
TINJAUAN HUKUM PENERAPAN AKAD IJARAH DAN INOVASI DARI AKAD IJARAH DALAM PERKEMBANGAN EKONOMI SYARIAH DI INDONESIA
Authors: Sakti Lanang , Adityarani Nadhira Wahyu 
Published: December 2020

Salah satu produk syariah yang ditawarkan kepada masyarakat adalah prinsip sewa-menyewa atau ijarah yang termasuk ke dalam ruang lingkup muamalah. Prinsip ijarah yang ditawarkan kepada masyarakat didasarkan pada sebuah perjanjian (akad). Transaksi muamalah melalui ijarah mengalami perkembangan dan terobosan baru dalam dunia perbankan modern, seperti ijarah operational lease dan ijarah berbentuk fnancial lease yang biasanya diterapkan dalamsistem perbankan syariah, sekarang telah mengalami perkembangan dengan diterapkannya ijarah dalam sistem pasar modal syariah yang berbentuk sukuk atau obligasi Syariah, sehingga perlu ada kajian lebih lanjut terkait bagaimana tinjauan hukum penerapan akad ijarah dan inovasi dari akad ijarah dalam perkembangan ekonomi syariah di Indonesia.
Penelitian ini menggunakan metode penelitian hukum normatif dengan menggunakan metode pendekatan yuridis normatif yang mengacu pada hukum dan peraturan perundang-undangan yang berlaku. Dalam penelitian ini menunjukkan bahwa perkembangan sistem perekonomian tidak hanya dalam sistem perbankan syariah saja melainkan dalam sistem pasar modal syariah, akad ijarah ini digunakan. Penerapan ini menciptakan inovasi dalam prinsip-prinsip ijarah, seperti akad ijarah muntahiah bit tamlik, sukuk ijarah dan sukuk ijarah SBSN
Síndrome de Bouveret: causa inusual de íleo biliar
Authors: Ramon y Cajal Calvo Juan , Bello Franco Carlota , Sesé Lacamara Laura , Costa Lorente Miguel , Moreno Caballero Leticia 
Published: December 2020

Introducción: El síndrome de Bouveret consiste en una obstrucción de la salida gástrica debido a la impactación de un cálculo biliar en el bulbo duodenal después de la migración a través de una fístula colecistoduodenal. Caso Clínico: Paciente con cuadro de dolor abdominal difuso de tipo cólico, diarreas y vómitos de aspecto amarillento. Las pruebas de imagen realizadas ponen de manifiesto una importante dilatación gástrica y duodenal con presencia de gas a nivel vesicular con la existencia de una fistula colecistoduodenal con una imagen redondeada intraluminal en yeyuno proximal compatibles con litiasis migrada. El paciente fue intervenido de urgencia mediante una enterotomía con la extracción del calculo y cierre de la misma. Discusión: El síndrome de Bouveret es una condición poco común de íleo biliar que causa una morbilidad y mortalidad significativa y, a menudo, ocurre en ancianos con comorbilidades importantes. Se requieren estrategias de diagnóstico y tratamiento individuales para un manejo y resultado óptimos, siendo el tratamiento endoscópico o la cirugía por vía abierta los dos tratamientos disponibles para la resolución del cuadro. Conclusión: El síndrome de Bouveret es una afección potencialmente mortal con obstrucción de la salida gástrica causada por cálculos biliares grandes. En la mayoría de los casos, se requiere una tomografía computarizada para su diagnóstico y si bien en algunos casos, los tratamientos percutáneos y endoscópicos pueden tener éxito como tratamiento de primera línea, la mayoría de los pacientes precisan de una cirugía para la extracción de cálculos.
Low Acceleration Voltage EBIC Using FESEM and Application to Cross-Sectional Junction Evaluation
Authors: Kadota Y. , Mori K. 
Published: December 2020

Abstract
EBIC (Electron beam induced current) method has been applied to the evaluation of half micron MOSFET junctions. We have been able to clearly measure the junction depth profile and the impurities density, using FESEM/EBIC which provides the highest SEM resolution currently available. We have found that it is necessary to understand the relation of the acceleration voltage and the primary electron beam current, in order to take full advantage of the FESEM/EBIC technique for junction evaluation. We have been able to experimentally demonstrate the accurate measurement of junction position.
A Technique for Achieving Precision Cross Sections of Released Surface Micromachined Structures
Authors: Woodilla D.J. 
Published: December 2020

Abstract
Surface micromachining of mechanical sensors is quickly becoming a part of integrated circuit technology. The accurate and reliable analysis of these sensors is critical to the development of such devices and the maintenance of quality in the fabrication process. One aspect of sensor analysis is cross section sample preparation for electron microscopy. This presents a new challenge to the analyst because these sensors require nontraditional sample preparation techniques. This paper presents a method of encapsulating surface micromachined sensors with thermosetting epoxy and a thin glass cover slip. Traditional precision polishing techniques are then used to achieve accurate and reliable cross sections.
Comparative TDR Analysis as a Packaging FA Tool
Authors: Odegard Charles , Lambert Craig 
Published: December 2020

Abstract
Time domain reflectometry (TDR) is increasingly being utilized as a failure analysis tool in the semiconductor industry. TDR can provide fast, nondestructive analysis of packaged integrated circuits. With one measurement, TDR analysis can provide instant identification of the general region of the fail site, whether it exists in the substrate, interconnect region, or in the die. A digital sampling oscilloscope with a TDR module supplies a fast risetime voltage edge to the signal pin of interest, and then records the subsequent voltage edge reflections. The time delay between the incident and reflected electrical signals are analyzed to characterize the electrical path of the signal pin. Initial implementation of TDR as an FA tool by the authors was in a comparative analysis method, where the TDR measurement from an unassembled substrate is used as the basis of comparison for the TDR measurement from the failing unit. Current development focuses on signature analysis of the TDR waveform for a given substrate path (including BGA substrate, flip-chip solder bump and pads, and flip-chip die). Interpretation of the TDR measurements for both comparative analysis and signature analysis of the TDR waveform will be discussed in this paper.
Contacting Silicon with FIB for Backside Circuit Edit
Authors: Boit C. , Kerst U. , Sadewater P. , Leihkaufa R. , Schömannb S. , Le Royc E. , Lundquistc T. 
Published: December 2020

Abstract
Process options of FIB circuit edit accessing active area in silicon through chip backside are presented. The full process is divided in modules. The technological readiness of the different modules is discussed. New results for the two most critical modules, endpoint detection of the global FIB trench in silicon, and contact resistivity of FIB deposited metal interconnect on diffusion, are presented. Investigated endpoint detection processes are FIB image contrast of the wells and of STI (shallow trench isolation). The contact to diffusion is in the range of 2-5 x 10-7 Ωcm2 on highly doped n-Si, about 10x higher on highly doped p-Si, with linear I-V characteristic.
A Novel Method for Deep Trench Profile Characterization and Process Monitoring in 90nm DRAM Technology
Authors: Huang Kuo-Hui , Gu Wen-Lon , Liu Ming-De , Wang Yu-Sen , Russell Jeremy D. 
Published: December 2020

Abstract
This article presents a novel method to provide whole Deep Trench (DT) profile inspection. Bevel angle top-down polishing is used on pre-rotated substrates instead of traditional cross-section cleaving. This method can feedback the precise DT profile shape at specific depths to the production line for process tuning and troubleshooting.