bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences and similarities of stellar populations in LAEs and LBGs at z ∼ 3.4−6.8
Authors: Arrabal Haro P , Rodríguez Espinosa J M , Muñoz-Tuñón C , Sobral D , Lumbreras-Calle A , Boquien M , Hernán-Caballero A , Rodríguez-Muñoz L , Alcalde Pampliega B 
Published: April 2020

ABSTRACT
Lyman alpha emitters (LAEs) and Lyman break galaxies (LBGs) represent the most common groups of star-forming galaxies at high z, and the differences between their inherent stellar populations (SPs) are a key factor in understanding early galaxy formation and evolution. We have run a set of SP burst-like models for a sample of 1558 sources at 3.4 &lt; z &lt; 6.8 from the Survey for High-z Absorption Red and Dead Sources (SHARDS) over the GOODS-N field. This work focuses on the differences between the three different observational subfamilies of our sample: LAE–LBGs, no-Ly α LBGs, and pure LAEs. Single and double SP synthetic spectra were used to model the spectral energy distributions, adopting a Bayesian information criterion to analyze under which situations a second SP is required. We find that the sources are well modelled using a single SP in $\sim 79{{\ \rm per\ cent}}$ of the cases. The best models suggest that pure LAEs are typically young low-mass galaxies ($t\sim 26^{+41}_{-25}$ Myr; $M_{\mathrm{star}}\sim 5.6^{+12.0}_{-5.5}\times 10^{8}\ M_{\odot }$), undergoing one of their first bursts of star formation. On the other hand, no-Ly α LBGs require older SPs (t ∼ 71 ± 12 Myr), and they are substantially more massive (Mstar ∼ 3.5 ± 1.1 × 109 M⊙). LAE–LBGs appear as the subgroup that more frequently needs the addition of a second SP, representing an old and massive galaxy caught in a strong recent star-forming episode. The relative number of sources found from each subfamily at each z supports an evolutionary scenario from pure LAEs and single SP LAE–LBGs to more massive LBGs. Stellar mass functions are also derived, finding an increase of M* with cosmic time and a possible steepening of the low-mass slope from z ∼ 6 to z ∼ 5 with no significant change to z ∼ 4. Additionally, we have derived the SFR–Mstar relation, finding an $\mathrm{SFR}\propto M_{\mathrm{star}}^{\beta }$ behaviour with negligible evolution from z ∼ 4 to z ∼ 6.
The heavier the better: how to constrain mass ratios and spins of high-mass neutron star mergers
Authors: Most Elias R , Weih Lukas R , Rezzolla Luciano 
Published: April 2020

ABSTRACT
The first binary neutron star merger event, GW170817, and its bright electromagnetic counterpart have provided a remarkable amount of information. By contrast, the second event, GW190425, with $M_{\rm tot}=3.4^{+0.3}_{-0.1}\, \mathrm{ M}_{\odot }$ and the lack of an electromagnetic counterpart, has hardly improved our understanding of neutron star physics. While GW190425 is compatible with a scenario in which the merger has led to a prompt collapse to a black hole and little ejected matter to power a counterpart, determining the mass ratio and the effective spin $\tilde{\chi }$ of the binary remains difficult. This is because gravitational waveforms cannot yet well constrain the component spins of the binary. However, since the mass of GW190425 is significantly larger than the maximum mass for non-rotating neutron stars, $M_{_{\rm TOV}}$, the mass ratio q cannot be too small, as the heavier star would not be gravitationally stable. Making use of universal relations and a large number of equations of state, we provide limits in the $(\tilde{\chi },q)$ plane for GW190425, namely qmin ≥ 0.38 and $\tilde{\chi }_{\rm max}\le 0.20$, assuming $M_\mathrm{tot} \simeq 3.4\, \mathrm{ M}_\odot$. Finally, we show how future observations of high-mass binaries can provide a lower bound on $M_{_{\rm TOV}}$.
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells
Authors: Wen Zengqi , Zhang Liwei , Ruan Haihe , Li Guohong 
Published: April 2020

AbstractNucleosome is the basic structural unit of chromatin, and its dynamics plays critical roles in the regulation of genome functions. However, how the nucleosome structure is regulated by histone variants in vivo is still largely uncharacterized. Here, by employing Micrococcal nuclease (MNase) digestion of crosslinked chromatin followed by chromatin immunoprecipitation (ChIP) and paired-end sequencing (MNase-X-ChIP-seq), we mapped unwrapping states of nucleosomes containing histone variant H2A.Z in mouse embryonic stem (ES) cells. We found that H2A.Z nucleosomes are more enriched with unwrapping states compared with canonical nucleosomes. Interestingly, +1 H2A.Z nucleosomes with 30–80 bp DNA is correlated with less active genes compared with +1 H2A.Z nucleosomes with 120–140 bp DNA. We confirmed the unwrapping of H2A.Z nucleosomes under native condition by re-ChIP of H2A.Z and H2A after CTCF CUT&RUN in mouse ES cells. Importantly, we found that depletion of H2A.Z results in decreased unwrapping of H3.3 nucleosomes and increased CTCF binding. Taken together, through MNase-X-ChIP-seq, we showed that histone variant H2A.Z regulates nucleosome unwrapping in vivo and that its function in regulating transcription or CTCF binding is correlated with unwrapping states of H2A.Z nucleosomes.
AnnoLnc2: the one-stop portal to systematically annotate novel lncRNAs for human and mouse
Authors: Ke Lan , Yang De-Chang , Wang Yu , Ding Yang , Gao Ge 
Published: April 2020

AbstractWith the abundant mammalian lncRNAs identified recently, a comprehensive annotation resource for these novel lncRNAs is an urgent need. Since its first release in November 2016, AnnoLnc has been the only online server for comprehensively annotating novel human lncRNAs on-the-fly. Here, with significant updates to multiple annotation modules, backend datasets and the code base, AnnoLnc2 continues the effort to provide the scientific community with a one-stop online portal for systematically annotating novel human and mouse lncRNAs with a comprehensive functional spectrum covering sequences, structure, expression, regulation, genetic association and evolution. In response to numerous requests from multiple users, a standalone package is also provided for large-scale offline analysis. We believe that updated AnnoLnc2 (http://annolnc.gao-lab.org/) will help both computational and bench biologists identify lncRNA functions and investigate underlying mechanisms.
Immunogenicity and Reactogenicity of a Reduced Schedule of a 4-component Capsular Group B Meningococcal Vaccine: A Randomized Controlled Trial in Infants
Authors: Valente Pinto Marta , O’Connor Daniel , Galal Ushma , Clutterbuck Elizabeth A , Robinson Hannah , Plested Emma , Bibi Sagida , Camara Pellisso Susana , Hughes Harri , Kerridge Simon , Mujadidi Yama F , Findlow Helen , Borrow Ray , Snape Matthew D , Pollard Andrew J 
Published: April 2020

Abstract

Background
The 4-component capsular group B meningococcal vaccine (4CMenB) was licensed as a 4-dose infant schedule but introduced into the United Kingdom as 3 doses at 2, 4, and 12 months of age. We describe the immunogenicity and reactogenicity of the 2 + 1 schedule in infants.

Methods
Infants were randomized to receive 4CMenB with routine immunizations (test group) at 2, 4, and 12 months or 4CMenB alone at 6, 8, and 13 months of age (control group). Serum bactericidal antibody (SBA) assay against a serogroup B meningococcal reference strain (44/76-SL), memory B-cell responses to factor H binding protein, Neisseria adhesion protein A, Neisseria heparin binding antigen, Porin A (PorA), and reactogenicity was measured.

Results
One hundred eighty-seven infants were randomized (test group: 94; control group: 93). In the test group, 4CMenB induced SBA titers above the putative protective threshold (1:4) after primary and booster doses in 97% of participants. Postbooster, the SBA GMT (72.1; 95% confidence interval [CI], 51.7–100.4) was numerically higher than the serum bactericidal antibody geometric mean titre (SBA GMT) determined post–primary vaccination (48.6; 95% CI, 37.2–63.4).
After primary immunizations, memory B-cell responses did not change when compared with baseline controls, but frequencies significantly increased after booster. Higher frequency of local and systemic adverse reactions was associated with 4CMenB.

Conclusions
A reduced schedule of 4CMenB was immunogenic and established immunological memory after booster.
Endoscopic Fenestration of Cavum Septum Pellucidum Cysts to the Third Ventricle: Technical Note
Authors: Simonin Alexandre , Bangash Omar , Chandran Arjun S , Uvelius Erik , Lind Christopher 
Published: April 2020

Abstract

BACKGROUND AND IMPORTANCE
Cavum septum pellucidum (CSP) and cavum vergae (CV) cysts are common incidental findings on imaging studies. However, they may rarely present with symptoms related to the obstruction of the foramen of Monro by the cyst leaflets. There is no consensus regarding the management of symptomatic CSP and CV cysts. We present an original transcavum interforniceal endoscopic fenestration technique. The step-by-step surgical procedure and two illustrative cases are presented.

CLINICAL PRESENTATION
A 31-yr-old male and a 24-yr-old woman presented with symptomatic CSP and CV cysts. For both patients, neuronavigation was used to plan the procedure. An endoscope was introduced into the cyst through a right frontal burr-hole. After an examination of the endoscopic anatomy, a communication between the cyst and the third ventricle was performed using an endoscopic forceps. In both cases, directly after the fenestration, cerebrospinal fluid (CSF) passed through the communication, and the collapse of the cyst was appreciated. Symptoms were relieved in both patients, and neuropsychological assessment improved. Postoperative imaging showed a reduction in the cyst bulge, and patent foramen of Monro.

CONCLUSION
Endoscopic fenestration of CSP and CV cysts to the third ventricle through an interforniceal navigated approach is a feasible and efficient surgical procedure. Theoretical advantages include a single tract through noneloquent brain, a perpendicular trajectory to the membrane for fenestration, and a large CSF space beyond the fenestration point.
In vitro evolution of phi29 DNA polymerases through compartmentalized gene expression and rolling-circle replication
Authors: Sakatani Yoshihiro , Mizuuchi Ryo , Ichihashi Norikazu 
Published: April 2020

AbstractPhi29 DNA polymerase is widely used for DNA amplification through rolling-circle replication or multiple displacement amplification. Here, we performed completely in vitro artificial evolution of phi29 DNA polymerase by combining the in vitro compartmentalization and the gene expression-coupled rolling-circle replication of a circular DNA encoding the polymerase. We conducted the experiments in six different conditions composed of three different levels of inhibitor concentrations with two different DNA labeling methods. One of the experiments was performed in our previous study and the other five experiments were newly conducted in this study. Under all conditions, we found several mutations that enhance the rolling-circle amplification by the polymerase when it was expressed in the reconstituted gene expression system. Especially, a combinatorial mutant polymerase (K555T/D570N) exhibits significantly higher rolling-circle activity than the wild type. These highly active mutant polymerases would be useful for various applications.
Digital phenotyping of negative symptoms: the relationship to clinician ratings
Authors: Cohen Alex S , Schwartz Elana , Le Thanh P , Cowan Tovah , Kirkpatrick Brian , Raugh Ian M , Strauss Gregory P 
Published: April 2020

Abstract
Negative symptoms are a critical, but poorly understood, aspect of schizophrenia. Measurement of negative symptoms primarily relies on clinician ratings, an endeavor with established reliability and validity. There have been increasing attempts to digitally phenotype negative symptoms using objective biobehavioral technologies, eg, using computerized analysis of vocal, speech, facial, hand and other behaviors. Surprisingly, biobehavioral technologies and clinician ratings are only modestly inter-related, and findings from individual studies often do not replicate or are counterintuitive. In this article, we document and evaluate this lack of convergence in 4 case studies, in an archival dataset of 877 audio/video samples, and in the extant literature. We then explain this divergence in terms of “resolution”—a critical psychometric property in biomedical, engineering, and computational sciences defined as precision in distinguishing various aspects of a signal. We demonstrate how convergence between clinical ratings and biobehavioral data can be achieved by scaling data across various resolutions. Clinical ratings reflect an indispensable tool that integrates considerable information into actionable, yet “low resolution” ordinal ratings. This allows viewing of the “forest” of negative symptoms. Unfortunately, their resolution cannot be scaled or decomposed with sufficient precision to isolate the time, setting, and nature of negative symptoms for many purposes (ie, to see the “trees”). Biobehavioral measures afford precision for understanding when, where, and why negative symptoms emerge, though much work is needed to validate them. Digital phenotyping of negative symptoms can provide unprecedented opportunities for tracking, understanding, and treating them, but requires consideration of resolution.
Decolonizing Global Health Education: Rethinking Institutional Partnerships and Approaches
Authors: Eichbaum Quentin G. , Adams Lisa V. , Evert Jessica , Ho Ming-Jung , Semali Innocent A. , van Schalkwyk Susan C. 
Published: April 2020

Global health often entails partnerships between institutions in low- and middle-income countries (LMICs) that were previously colonized and high-income countries (HICs) that were colonizers. Little attention has been paid to the legacy of former colonial relationships and the influence they have on global health initiatives. There have been recent calls for the decolonization of global health education and the reexamination of assumptions and practices under pinning global health partnerships.
Medicine’s role in colonialism cannot be ignored and requires critical review. There is a growing awareness of how knowledge generated in HICs defines practices and informs thinking to the detriment of knowledge systems in LMICs. Additionally, research partnerships often benefit the better-resourced partner.
In this article, the authors offer a brief analysis of the intersections between colonialism, medicine, and global health education and explore the lingering impact of colonialist legacies on current global health programs and partnerships. They describe how “decolonized” perspectives have not gained sufficient traction and how inequitable power dynamics and neocolonialist assumptions continue to dominate. They discuss 5 approaches, and highlight resources, that challenge colonial paradigms in the global health arena. Furthermore, they argue for the inclusion of more transfor mative learning approaches to promote change in attitudes and practice. They call for critical reflection and concomitant action to shift colonial paradigms toward more equitable partnerships in global education.
The Transition From Medical Student to Resident: A Qualitative Study of New Residents’ Perspectives
Authors: Chang Lucy Y. , Eliasz Kinga L. , Cacciatore Danielle T. , Winkel Abigail Ford 
Published: April 2020

Purpose
To understand the learner’s perspective on the transition from medical school to residency and to develop a conceptual model for how learners experience the transition from student to resident.

Method
This prospective qualitative study explored the experience of first-year residents using semistructured, one-on-one telephone interviews. Ten first-year residents who participated in the Transition to Residency elective as fourth-year students at the New York University Grossman School of Medicine in April 2018 participated from December 2018 to April 2019. Using a 3-phase coding process and grounded theory methodology, the authors identified categories, which they organized into broader themes across interview transcripts and used to develop a conceptual model.

Results
From the perspective of new residents, developing professional identity is the core construct of the transition experience. The residents focused on individual aspects of the experience—professional identity, self-awareness, professional growth, approach to learning, and personal balance—and external aspects—context of learning, professional relationships, and challenges in the context of their new role. Across these 8 categories, 5 broader themes emerged to describe an abrupt change in educational environment, an immersive experience of learning as a resident, ambivalence and tensions around the new role, navigation of professional relationships, and balance and integration of working in medicine with personal lives and goals. A conceptual model illustrates this phenomenon as a cell where professional identity and growth (the nucleus) is surrounded by interactions with patients and other members of the medical team (in the cytoplasm) that create a substrate for learning and development.

Conclusions
This study suggests that being immersed in the residency experience is how medical students transition to resident physicians. Educational interventions that allow learners to acclimate to the experience of being a doctor through gradual exposure to authentic interactions have the potential to bridge the abrupt transition.
Association between Use of Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers and Postoperative Delirium
Authors: Farag Ehab , Liang Chen , Mascha Edward J. , Argalious Maged Y. , Ezell Jacob , Maheshwari Kamal , Esa Wael Ali Sakr , Troianos Christopher A. , Sessler Daniel I. 
Published: April 2020

Background
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients. Post hoc, the association between postoperative use of angiotensin system inhibitors and delirium was assessed.

Methods
The authors conducted a single-site cohort study of adults admitted to Cleveland Clinic critical care units after noncardiac procedures between 2013 and 2018 who had at least one Confusion Assessment Method delirium assessment. Patients with preexisting dementia, Alzheimer’s disease or other cognitive decline, and patients who had neurosurgical procedures were excluded. For the primary analysis, the confounder-adjusted association between preoperative angiotensin inhibitor use and the incidence of postoperative delirium was assessed. Post hoc, the confounder-adjusted association between postoperative angiotensin system inhibitor use and the incidence of delirium was assessed.

Results
The incidence of delirium was 39% (551 of 1,396) among patients who were treated preoperatively with angiotensin system inhibitors and 39% (1,344 of 3,468) in patients who were not. The adjusted odds ratio of experiencing delirium during critical care was 0.98 (95% CI, 0.86 to 1.10; P = 0.700) for preoperative use of angiotensin system inhibitors versus control. Delirium was observed in 23% (100 of 440) of patients who used angiotensin system inhibitors postoperatively before intensive care discharge, and in 41% (1,795 of 4,424) of patients who did not (unadjusted P < 0.001). The confounder-adjusted odds ratio for experiencing delirium in patients who used angiotensin system inhibitors postoperatively was 0.55 (95% CI, 0.43 to 0.72; P < 0.001).

Conclusions
Preoperative use of angiotensin system inhibitors is not associated with reduced postoperative delirium. In contrast, treatment during intensive care was associated with lower odds of delirium. Randomized trials of postoperative angiotensin-converting enzymes inhibitors and angiotensin receptor blockers seem justified.

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New
The Incidence of Venous Thromboembolism Following Pelvic and Lower Extremity Trauma Despite Adherence to Modern Prophylactic Protocols
Authors: Lowe Jason A. , Mitchell Sean M. , Agarwal Sumit , Jones Clifford B. 
Published: April 2020

Objectives:
Describe the incidence of venous thromboembolism (VTE) in patients with pelvic and lower extremity long bone trauma in the setting of modern prophylaxis.

Design:
Retrospective health-system database study.

Setting:
Multi-center health care system.

Patients:
Database query from 2010 to 2017 identified 11,313 adult trauma patients who received open reduction internal fixation of pelvic, acetabular, femoral neck, or intertrochanteric fractures, or received intramedullary nailing (IMN) of the femoral or tibial shaft. Patients with incomplete prophylaxis, prior history of VTE, coagulopathy, or concomitant lower extremity fracture were excluded.

Intervention:
Mechanical and chemical VTE prophylaxis following pelvic or lower extremity fracture fixation.

Main Outcome Measurements:
VTE rates.

Results:
The overall VTE rate was 0.82% [0.39% deep venous thromboses (DVT); 0.43% pulmonary emboli (PE)]. By procedure, pelvic open reduction and internal fixation (ORIF) and femoral IMN had the highest VTE rates 1.70% (0.98% DVT; 0.78% PE) and 1.33% (0.75% DVT; 0.58% PE), whereas tibial IMN had the lowest incidence of VTE 0.34% (0.17% DVT; 0.17% PE). Among hip fractures, femoral neck ORIF had a VTE rate of 0.98% (0.59% DVT; 0.39% PE), whereas intertrochanteric ORIF had lower rates of 0.59% (0.20% DVT; 0.39% PE).

Conclusions:
Despite adherence to modern VTEp protocols, nonpreventable VTE occur in 0.82% of pelvic and lower extremity orthopaedic trauma patients. Incidence ranged between 0.34% and 1.70% depending on injury/fixation method with the highest rate observed in pelvis ORIF followed by femoral IMN. In the era of pay for quality performance, it is important for health systems and auditing agencies to reconcile the difference between preventable and nonpreventable VTEs.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.