bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Study between SNPs within MicroRNA Binding Sites and the Prognosis of Breast Cancer
Authors: Zhang Liwen , Han Lu , Huang Yubei , Feng Ziwei , Wang Xin , Li Haixin , Song Fangfang , Liu Luyang , Li Junxian , Zheng Hong , Wang Peishan , Song Fengju , Chen Kexin 
Published: April 2020

Abstract
Background: Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to the prognosis of cancer. We performed this study to explore the association between SNPs within microRNA binding sites and the prognosis of breast cancer.Methods: We carried out a two-stage study including 2647 breast cancer patients. In stage I, we genotyped 192 SNPs within microRNA binding sites using the Illumina Goldengate platform. In stage II, we validated SNPs significantly associated with breast cancer prognosis in another dataset using the TaqMan platform. Survival times was calculated, and Kaplan-Meier curves and Cox regression model were used to analyze survival of breast cancer patients with different genotypes.Results: We identified 8 SNPs significantly associated with breast cancer prognosis in stage I (P<0.05), and only rs10878441 was statistically significant in stage II (AA vs CC: adjusted HR=2.21, 95% CI: 1.11-4.42, P=0.024). We combined the data from stage I and stage II, and found that, compared with rs10878441 AA genotype, CC genotype was significantly associated with poor survival of breast cancer (HR=1.69, 95% CI: 1.18-2.42, P=0.004; adjusted HR=2.19, 95% CI: 1.30-3.70, P=0.003). Stratified analyses demonstrated that rs10878441 was related to breast cancer prognosis in grade II patients and lymph node-negative patients (P<0.05).Conclusions: The LRKK2 rs10878441 CC genotype is associated with poor prognosis of breast cancer in a Chinese population, and it could be used as a potential prognostic biomarker for breast cancer. Further studies are warranted.
Altering the properties of the magnetic Co ferrite nanoparticles fabricated by modified inverse coprecipitation for high-frequency applications
Authors: Al-Kershi Rabea , Aldirham S. H. 
Published: April 2020

Abstract
Magnetic Co ferrite nanoparticles doped with non-magnetic ions (Zn2+) fabricated by modified inverse coprecipitation technique. X-ray calculations show that the average crystallite size (D) and the average lattice constant (a) of CoZn ferrite nanoparticles increase from 32.33 to 52.87 nm and from 8.39 to 8.41Ǻ respectively with increasing non-magnetic Zn2+ ions from 0.00 to 0.55. Morphological forms and M-O at A and B sites studied by SEM and FT-IR spectroscopy. Measurements of the structural, optical, electrical and magnetic characterization of the CoZn ferrite nanoparticles strongly depend on non-magnetic Zn2+ ions content (y). Non-magnetic ions transform Co ferrite from hard and dielectric nature to soft and semiconductor nature. Values of Coercivity and the remanence decrease as non-magnetic Zn2+ ions increases to the minimum values 955 Oe and 6 emu /g for the sample with Zn = 0.55. Co0.45Zn0.55Fe2O4 is might be suitable for high-frequency applications where it has the smallest value of optical gap, the largest value of resistivity and the lowest value of dielectric loss factor.
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) and Modulating Inflammation on the Gut-brain Axis
Authors: Xie Zeping , Lu Hui , Yang Sixia , Zeng Yi , Li Wei , Wang Linlin , Luo Guanfeng , Fang Fang , Zeng Ting , Cheng Weidong 
Published: April 2020

Abstract
Background Alzheimer’s disease (AD), as the most prime cause of dementia, is a fatal neurodegenerative disease characterized by progressive cognitive decline and memory loss. However, A range of therapeutic approaches have shown unsatisfactory outcomes in clinical setting. Thus, it is critical to develop alternative therapies for the treatment of AD. Salidroside(SAL), a herb-derived phenylpropanoid glycoside compound, has been shown to attenuate LPS-induced cognitive impairment. However, the mechanism underlying its neuroprotective effects remains unclear. Here we show a therapeutic effect of SAL in a reliable and stable mouse model of AD, Senescence-Accelerated Mice Prone 8 (SAMP8).Methods SAMP8 were treated with salidroside, donepezil or saline, cognitive behavioral impairments were assessed using the Morris water maze, Y-maze, and open-field tests. Fecal samples were collected and analyzed by 16S rRNA sequencing, performed on the Illumina MiSEq. Brain samples were analyzed by immunohistochemistry and western blot to detect Beta Amyloid 1–42 deposition. Activation in microglia and neuroinflammatory cytokines was detected by immunofluorescence, Western blot and qPCR. Serum was analyzed by a Mouse High Sensitivity T Cell Magnetic Bead Panel and performed on the Luminex-MAGPIX multiplex immunoassay system.Results Our results suggested that SAL effectively alleviated hippocampus-dependent memory impairment in SAMP8, and showed no significant difference compared with the donepezil-administration group. SAL significantly (1) reduced toxic beta-amyloid (Abeta) 1–42 deposition; (2) reduced activation of microglia and attenuated proinflammatory factors, IL-1β, IL-6, and TNF-α, in the brain; (3) improved the gut barrier integrity and modified the gut microbiota (reversed the ratio of Bacteroidetes to Firmicutes, and eliminated Clostridiales and Streptococcaceae, which may have been associated with cognitive deficits); and (4) decreased the levels of proinflammatory cytokines in the peripheral circulation, IL-1α, IL-6, IL-17A and IL-12 in particular, according to a multiplex immunoassay.Conclusion In summary, SAL reversed AD-related changes in SAMP8 potentially through the regulation of the microbiota-gut-brain axis and by modulating inflammation in both peripheral circulation and central nervous system. Our results strongly suggest a therapeutic effect of SAL on cognition-related changes in SAMP8 and highlight its value as a potential source for drug development.
Prevalence and Drivers of Tobacco use Among Young Men in Sub-Saharan Africa: Evidence from 21 Nationally Representative Surveys
Authors: Darteh Eugene Kofuor Maafo , Yaya Sanni , Dickson Kwamena Sekyi , Seidu Abdul-Aziz 
Published: April 2020

Abstract
Background Tobacco consumption – including smoking, chewing tobacco and snuff has been recognized as a global public health issue and a major cause of premature mortality and morbidity. An annual estimated figure of more than 7 million people dies due to tobacco consumption with more than 6 million of those deaths attributed to direct tobacco use and about 890, 000 resulting from exposure to second-hand smoke. This paper seeks to examine the prevalence and drivers of tobacco use among young men in sub-Saharan Africa.Methods Using pooled data from the most recent Demographic and Health Survey (DHS) conducted between January 1, 2010, and December 3, 2018, in 21 countries that had data on tobacco use in SSA this paper examines tobacco use among young men in sub-Saharan Africa. A chi-square was conducted at the bivariate level to test for the significance of tobacco use across the socio-demographic characteristics. A binary logistic regression test was conducted at the multi-variate level to estimate the determinants of tobacco use among young people in SSA. The confidence interval for both the bivariate and multivariate tests was 95%.Results The overall prevalence of tobacco use was 9.34% (95% CI: 7.52–11.16) with the lowest prevalence in Ghana (1.46%) and the highest in Lesotho (39.19%). It was also found that those aged 20–24 [AOR = 3.080, CI = 2.840–3.341], engaged in unskilled labour [AOR = 2.651, CI = 2.333–3.012], who are widowed/divorced/separated [AOR = 2.747, CI= [2.301–3.279] and with no religion [AOR = 1.460, CI = 1.273–1.676] had higher odds of using tobacco. On the other hand, young, men with secondary [AOR = 0.726, CI = 0.645–0.818] and higher [AOR = 0.563, CI= [0.446–0.710] level of education, those in the richest wealth quintile[AOR = 0.758, CI = 0.660–0.871], those in rural areas [AOR = 0.869, CI = 0.795–0.950], and those who read newspaper or magazine at least once a week [AOR = 0.898, CI = 0.808–0.998] had lower odds of tobacco use.Conclusion Age, level of education, wealth status, working status, marital status, religion and place of residence were statistically significant association with tobacco use among young men in SSA. These socioeconomic factors should be considered when trying to tackle tobacco use in SSA. Specific public health interventions should take into account these socio-economic factors to reduce tobacco use among young people in SSA
Near-fatal experience due to delayed diagnosis of type 1 diabetes during the COVID-19 pandemic
Authors: Dayal Devi , Gupta Saniya , Raithatha Dhvani , Soni Prakash , Thapa Surjeet , Baranwal Arun 
Published: April 2020

Abstract
The focus of national governments and the medical profession on the pandemic of coronavirus disease 2019 (COVID-19) has resulted in neglect of care for children with new onset illnesses. Type 1 diabetes (T1D), the most common endocrine disorder in children, is prone to rapid deterioration if not diagnosed in time. We recently encountered a child who presented in a critical condition and was later diagnosed to have diabetic ketoacidosis. We discuss the circumstances arising out of the severe lockdown restrictions for COVID-19, which resulted in difficulties in accessing the healthcare services and caused significant delay in the diagnosis of T1D and a near-death experience. It is essential to keep the non-COVID healthcare services open for children with new onset illnesses and those with chronic conditions for timely access in order to reduce morbidity and mortality due to these conditions.
2019 Novel Coronavirus (COVID-19) pneumonia: an unusual lung ultrasound presentation.
Authors: Consoli Letizia , Bendotti Vittorio , Cicchinelli Sara , Gaioni Federico , Prandolini Paola , Bettonagli Monica , Terragnoli Paolo 
Published: April 2020

Abstract
In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients had a severe course, requiring intensive care, with an overall case fatality rate of 2.3%. In diagnosis, chest computed tomography most commonly showed ground-glass opacity with or without consolidative patterns.Herein we report a case of a patient affected by COVID-19 pneumonia referred in the emergency department of our institution on 4 April 2020 with peculiar lung ultrasound findings.
Prevalence and determinants of contraceptives use among rural young women (15-24 years) in Ghana
Authors: Salifu Mohammed Gazali , Mohammed Kamaldeen , Harrison Mac-Cauley , Atimpe Aaron , Abukari Rogers Wuniwumda , Avoka Vasco Ayere , Abdul-Rahman Mubarik 
Published: April 2020

Abstract
Background: Contraceptives use has significant effect on controlling fertility, preventing STIs, reducing unwanted pregnancies and induced abortions. The use of contraceptives among reproductive age women (15-49 years) has been largely reported. However, what is unclear is whether the reported prevalence of, and factors that influence the usage of contraceptives is comparable in the context of young adults (aged 15-24 years) in rural areas. The purpose of this study was therefore to report the prevalence and factors that influence contraceptives use among young women (15-24 years) in rural Ghana.Methods: Data (n = 3797) collected using a questionnaire through a mutli-stage probability sampling method in the 2017 Ghana Maternal Health Survey (GMHS) was analyzed by descriptive and inferential statistical methods. The chi-square test was used to identify significant associations between categorical variables at a significant level of p < 0.05. Univariate and multivariate logistic regression analyses was conducted to explore how well each independent variable predicted contraceptive use. Results: Out of the 3,797 women, only 21.49% (95% CI: 19.56, 23.55) used contraceptives. Number of living children, health insurance, knowledge of fertility period, history of abortion, ever given birth, educational level, age of participants and current union were found to influence contraceptives use. Strong significant predictors (at 95% CI, p<0.05) of contraceptives use were history of abortion, age of participants, educational level, number of living children, and knowledge of fertility period. Conclusion: Low usage of contraceptives has been identified among rural women and so there is the need for policymakers to intensify education and facilitate widespread access to modern contraceptives in rural areas and promote their effective use.
Mental health outcomes of quarantine and isolation for infection prevention: A systematic umbrella review of the global evidence
Authors: Hossain Md Mahbub , Sultana Abida , Purohit Neetu 
Published: April 2020

Abstract
Background: Transmission of infectious diseases is often prevented by quarantine and isolation of the populations at risk. These approaches restrict the mobility, social interactions, and daily activities of the affected individuals. In recent novel coronavirus disease (COVID-19) pandemic, quarantine and isolation are being adopted in many contexts, which necessitates an evaluation of global evidence on how such measures impact the mental health outcomes among populations. This umbrella review aimed to synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.Materials and methods: We searched nine major databases and additional sources and included articles if they were systematically conducted reviews, published as peer-reviewed journal articles, and reported mental health outcomes of quarantine or isolation in any population.Results: Among 1364 citations, only eight reviews met our criteria. Most of the primary studies in those reviews were conducted in high-income nations and in hospital settings. These articles reported a high burden of mental health problems among patients, informal caregivers, and healthcare providers who experienced quarantine or isolation. Prevalent mental health problems among the affected individuals include depression, anxiety, mood disorders, psychological distress, posttraumatic stress disorder, insomnia, fear, stigmatization, low self-esteem, lack of self-control, and other adverse mental health outcomes.Conclusion: This umbrella review found severe mental health problems among individuals and populations who have undergone quarantine and isolation in different contexts. This evidence necessitates multipronged interventions including policy measures for strengthening mental health services globally and promoting psychosocial wellbeing among high-risk populations.
The Association of Country-Level Factors with Outcomes of COVID-19: Analysis of the pandemic after one million cases
Authors: Aldibasi Omar S. , Alharbi Naif K. , Alkelya Mohamed , Zowawi Hosam , Alghnam Suliman 
Published: April 2020

Abstract
Background: Coronavirus infectious disease 2019 (COVID-19) is an ongoing global pandemic. Without a vaccine or an effective treatment in the near horizon, only public health measures have been effective in potentially reducing its impact. Due to the wide disparity in current response from individual countries, studying factors associated with public health measures may inform ongoing efforts. Therefore, this study aims to analyze the contributing factors across the globe with specific measures of the disease. Methods: This is a cross-sectional study that used publicly available data of COVID-19 cases as of April 6, 2020. We analyzed country public information on demographic and socioeconomic indicators published in different sources. The association between country-level variables and the incidence rate, the recovery rate, severity of the cases, and mortality rate were evaluated using regression techniques. Results: Multiple factors were found to be significantly associated with COVID-19 outcomes. The number of tests per million, GDP per capita, a country population size of 2020, country median age, and life expectancy are associated with the incidence rate of COVID19. The yearly net change population, migrants, and tourism are associated with the recovery rate of COVID-19. The number of tests per million and male life expectancy are associated with the critical cases rate of COVID-19. Finally, the GDP per capita, land area (Km2), life expectancy, and tourism are associated with the mortality rate of COVID-19. Conclusion: Overall, higher GDP per capita, median age, and a higher number of lab tests were found to be associated with more incidents of COVID-19 cases, which indicates a better and maintained system for detection, reporting, and management of the pandemic. This study suggests that investing in better screening and testing may reveal more cases that can be managed and controlled; while limiting travelers would further support the pandemic control.
Forecast of COVID-19 related deaths in the USA
Authors: Middelburg Rutger A , Rosendaal Frits R 
Published: April 2020

Abstract
ObjectiveDifferent governments have adopted different containment strategies for SARS-CoV-2. We compared reports of COVID-19 related deaths between countries with different strategies.DesignPublicly available data on numbers of reported COVID-19 related deaths between January 1st and April 2nd 2020 were compared between countries.ResultsIn countries that implemented strict containment strategies as soon as the virus was firmly established (e.g., Italy and Spain) the epidemic developed similarly to the development in China. Extrapolation suggests the cumulative number of deaths in Italy and Spain to rise to about 22,000 and 41,000, respectively. In South Korea where containment strategies were implemented before the virus arrived, the epidemic developed much slower. In the United States, however, where measures were taken later, the epidemic is developing explosively. Cumulative numbers of deaths in the New York, New Jersey, and Michigan area are forecast to reach about 15,000. Of note, 85% of these deaths are likely to occur within the first 50 days of the epidemic (i.e. before the end of April 2020).ConclusionsAlthough the future development of the epidemic remains difficult to predict accurately, current data suggest the United States will experience an explosive increase in deaths due to COVID-19 before the end of April 2020. Drastic measures are needed immediately to prevent other parts of the country from experiencing a development of this epidemic which is as dramatic as that seen in New York, New Jersey and Michigan.
Disabilitas dan In(ter)karnasi: Memaknai Relasi Persahabatan dalam Pelayanan Pastoral
Authors: Verdino Timotius 
Published: April 2020

AbstractThe development of incarnation theology has taken into account people with disabilities. However, the incarnation tends to be understood in a single corporeal identity, whilst disability shows the multiplicity of identities of socially constructed bodies. How do we see the incarnation in a disability perspective that embraces the multiplicity of body identity? Mayra Rivera, based on Maurice Merleau-Ponty’s philosophy, spoke of intercarnation as an alternative to the incarnation in a social perspective. This article points out that discussing the incarnation in the perspective of disability with a social model leads to the idea of intercarnation. In dealing with this case, the discourse about intercanation among feminist theologians would be helpful for the theology of disability.
AbstrakPengembangan teologi inkarnasi telah memperhitungkan faktor orang-orang dengan disabilitas. Akan tetapi, inkarnasi cenderung dipahami dalam sebuah identitas korporeal tunggal, padahal disabilitas menunjukkan adanya multiplisitas identitas tubuh yang dikonstruksi secara sosial. Bagaimana melihat inkarnasi dalam perspektif disabilitas yang merangkul multiplisitas identitas tubuh? Mayra Rivera, yang berangkatdari filsafat Maurice Merleau-Ponty, berbicara tentang interkarnasi sebagai sebuah alternatif terhadap perbincangan inkarnasi dalam perspektif sosial. Artikel ini menunjukkan bahwa membahas inkarnasi dalam perspektif disabilitas dengan model sosial akan mencapai gagasan tentang interkarnasi. Dalam mengkaji hal ini, diskursus tentang interkarnasi yang selama ini didominasi oleh teolog-teolog feminis akan bermanfaat bagi teologi disabilitas.
A Comprehensive Review of Monoamine Oxidase-A Inhibitors in their Syntheses and Potencies
Authors: Rehuman Nisha A. , Mathew Bijo , Jat Rakesh K. , Nicolotti Orazio , Kim Hoon 
Published: April 2020

Background:
Monoamine oxidases (MAOs) play a crucial role during the development of
various neurodegenerative disorders. There are two MAO isozymes, MAO-A and MAO-B. MAO-A is
a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative
transformations of neurotransmitters like serotonin, norepinephrine, and dopamine.

Materials and Method:
Focus on synthetic studies has culminated in the preparation of many MAOA
inhibitors, and advancements in combinatorial and parallel synthesis have accelerated the
developments of synthetic schemes. Here, we provided an overview of the synthetic protocols
employed to prepare different classes of MAO-A inhibitors. We classified these inhibitors according to
their molecular scaffolds and the synthetic methods used.

Results:
Various synthetic and natural derivatives from a different class of MAO-A inhibitors were reported.

Conclusion:
The review provides a valuable tool for the development of a new class of various
selective MAO-A inhibitors for the treatment of depression and other anxiety disorders.
Life Time Improvement of Hierarchically Structured SAPO-34 Nanocatalyst in MTO Reaction via Applying Clinoptilolite: Investigating of Composite Design via RSM
Authors: Yazdanpanah Reza , Moradiyan Eshagh , Halladj Rouein , Askari Sima 
Published: April 2020

Aim and Objective:
The research focuses on recent progress in the production of light
olefins. Hence, as the common catalyst of the reaction (SAPO-34) deactivates quickly because of
coke formation, we reorganized the mechanism combining SAPO-34 with a natural zeolite in order
to delay the deactivation time.

Materials and Methods:
The synthesis of nanocomposite catalyst was conducted hydrothermally
using experimental design. Firstly, Clinoptilolite was modified using nitric acid in order to achieve
nano-scaled material. Then, the initial gel of the SAPO-34 was prepared using DEA, aluminum
isopropoxide, phosphoric acid and TEOS as the organic template, sources of Aluminum, Phosphor,
and Silicate, respectively. Finally, the modified zeolite was combined with SAPO-34's gel.

Results:
20 different catalysts due to D-Optimal design were synthesized and the nanocomposite
with 50 weight percent of SAPO-34, 4 hours Crystallization and early Clinoptilolite precipitation
showed the highest relative crystallinity, partly high BET surface area and hierarchical structure.

Conclusion:
Different analyses illustrated the existence of both components. The most important
property alteration of nanocomposite was the increment of pore mean diameters and reduction in
pore volumes in comparison with free SAPO-34. Due to the low price of Clinoptilolite, the new
catalyst renders the process as economical. Using this composite, according to the formation of
multi-sized pores located hierarchically on the surface of the catalyst and increased surface area,
significant amounts of Ethylene and Propylene, in comparison with free SAPO-34, were produced,
as well as the deactivation time was improved.