bluuebunny/crossref_metadata_2025_split huggingface dataset:
Derivation of age-adjusted LACE index thresholds in the prediction of mortality and frequent hospital readmissions in adults
Authors: Fry Christopher Henry , Heppleston Erica , Fluck David , Han Thang Sieu 
Published: July 2020

AbstractThe LACE index has been shown to predict hospital readmissions and death with variable accuracy. A LACE index ≥ 10 is considered as high risk in the existing literature. We aimed to derive age-specific LACE index thresholds in the prediction of mortality and frequent readmissions. Analysis of prospectively collected data of consecutive alive-discharge episodes between 01/04/2017 and 31/03/2019 to a single hospital was conducted. The derivation of LACE index thresholds for predicting all-cause mortality within 6 months of hospital discharge or frequent readmissions (≥ 2 times within 28 days) was examined by receiver operating characteristics (ROC) in 32270 patients (14878 men, 17392 women) aged 18–107 year (mean = 64.0 years, SD = 20.5). For all patients with a LACE index ≥ 10, the area under the curve (AUC) for predicting mortality was 80.5% (95% CI 79.7–81.3) and for frequent readmissions was 84.0% (83.0–85.1). Two-graph ROC plots showed that the LACE index threshold where sensitivity equates specificity was 9.5 (95% intermediate range = 5.6–13.5) for predicting mortality and 10.3 (95% intermediate range = 6.6–13.6) for frequent readmissions. These thresholds were lowest among youngest individuals and rose progressively with age for mortality prediction: 18–49 years = 5.0, 50–59 years = 6.5, 60–69 years = 8.0, 70–79 years = 9.8 and ≥ 80 years = 11.6, and similarly for frequent readmissions: 18–49 years = 5.1, 50–59 years = 7.5, 60–69 years = 9.1, 70–79 years = 10.6 and ≥ 80 years = 12.0. Positive and negative likelihood ratios (LRs) ranged 1.5–3.3 and 0.4-0.6 for predicting mortality, and 2.5–4.4 and 0.3–0.6 for frequent readmissions, respectively, with stronger evidence in younger than in older individuals (LRs further from unity). In conclusion, the LACE index predicts mortality and frequent readmissions at lower thresholds and stronger in younger than in older individuals. Age should be taken into account when using the LACE index for identifying patients at high risk.
Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly
Authors: Bernabéu Ignacio , Fajardo Carmen , Marazuela Mónica , Cordido Fernando , Venegas Eva María , de Pablos-Velasco Pedro , Maroto Gonzalo Piedrola , Olvera María Pilar , de Paz Isabel Pavón , Carvalho Davide , Romero Carme , De la Cruz Guillermo , Escolá Cristina Álvarez 
Published: July 2020

Abstract
Purpose
Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin analogues (SSAs). We further evaluated the effectiveness of lanreotide autogel 120 mg delivered at EDIs (>4 weeks) in routine clinical practice.

Methods
Cross-sectional, multicentre, observational study conducted to determine the effectiveness—measured by control of serum insulin-like growth factor 1 (IGF-1)—of lanreotide autogel 120 mg at dosing intervals >4 weeks for ≥6 months in selected patients with acromegaly treated in routine clinical practice (NCT02807233). Secondary assessments included control of growth hormone (GH) levels, treatment adherence, patient satisfaction, and quality of life (QoL) using validated questionnaires (EQ-5D, AcroQoL, and TSQM-9). Patients who received radiotherapy within the last 6 months were excluded.

Results
Among 109 patients evaluated, mean (SD) age was 59.1 (13.2) years. IGF-1 values were normal (mean [SD]: 175.0 [74.5], 95% CI: 160.8 –189.1) in 91.7% of cases and normal in 91.4% of patients without previous radiotherapy treatment (n = 81). GH levels were ≤2.5 and ≤1 ng/mL, respectively, in 80.6% and 58.3%. Most patients were treated either every 5–6 (57.8%) or 7–8 weeks (38.5%), with 2.8% treated greater than every 8 weeks. The mean AcroQoL score was 63.0 (20.1). The mean global treatment satisfaction score (TSQM-9) was 75.1 (16.6). Treatment adherence (defined as no missed injections) was 94.5%.

Conclusion
Lanreotide autogel 120 mg at intervals of >4 weeks provided IGF-1 control in more than 90% of patients with acromegaly. Treatment satisfaction and adherence were good. These findings support use of extended dosing intervals in patients who have achieved good biochemical control with long-acting SSAs.
Conversion of CO2 during the DFB biomass gasification process
Authors: Mauerhofer A. M. , Müller S. , Bartik A. , Benedikt F. , Fuchs J. , Hammerschmid M. , Hofbauer H. 
Published: July 2020

AbstractIn many industrial processes, the climate-damaging gas CO2is produced as undesired by-product. The dual fluidized bed biomass gasification technology offers the opportunity to tackle this problem by using the produced CO2within the process as gasification agent. Therefore, a 100 kWthpilot plant at TU Wien was used to investigate the use of CO2as gasification agent by converting softwood as fuel and olivine as bed material into high-valuable product gas. A parameter variation was conducted, where the typically used gasification agent steam was substituted stepwise by CO2. Thereby, the amount of CO and CO2increased and the content of H2decreased in the product gas. These trends resulted in a declining H2/CO ratio and a decreasing lower heating value when CO2was increased as gasification agent. In contrast to these declining trends, the carbon utilization efficiency showed an increasing course. As second part of this work, a temperature variation from 740 to 840 °C was conducted to investigate the change of the main product gas components. With increasing temperature, CO and H2increased and CO2decreased. To determine the degree of conversion of CO2in the DFB reactor system, two approaches were selected: (1) a carbon balance and (2) a hydrogen balance. This way, it was found out that a certain amount of CO2was indeed converted at the investigated process conditions. Furthermore, under certain assumptions, the reverse water-gas shift reaction was identified to be the predominant reaction during CO2gasification.
Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae: a case series and review of the literature
Authors: Oliva Alessandra , Siccardi G. , Migliarini A. , Cancelli F. , Carnevalini M. , D’Andria M. , Attilia I. , Danese V. C. , Cecchetti V. , Romiti R. , Ceccarelli G. , Mastroianni C. M. , Palange P. , Venditti M. 
Published: July 2020

AbstractIntroductionThe novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection withMycoplasma pneumoniaehas been described both in adults and pediatrics whereas only two cases ofChlamydia pneumoniaehave been reported in a large US study so far.MethodsIn the present report, we describe a series of seven patients where co-infection withC. pneumoniae(n = 5) orM. pneumoniae(n = 2) and SARS-CoV-2 was detected in a large teaching hospital in Rome.Results and conclusionAn extensive review of the updated literature regarding the co-infection between SARS-CoV-2 and these atypical pathogens is also performed.
Low-temperature sintering and microwave dielectric properties of CaMg1−xLi2xSi2O6 (x = 0−0.3) ceramics
Authors: Huang Fangyi , Su Hua , Li Yuanxun , Zhang Huaiwu , Tang Xiaoli 
Published: July 2020

AbstractIn this study, low-temperature fired CaMg1−xLi2xSi2O6microwave dielectric ceramics were prepared via the traditional solid-state reaction method. In this process, 0.4 wt% Li2CO3-B2O3-SiO2-CaCO3-Al2O3(LBSCA) glass was added as a sintering aid. The results showed that ceramics consisted of CaMgSi2O6as the main phase. The second phases were CaSiO3always existing and Li2SiO3occurring at substitution contentx> 0.05. Li+substitution effectively lowered sintering temperature due to 0.4 wt% LBSCA and contributed to grain densification, and the most homogeneous morphology could be observed atx= 0.05. The effects of relative density, the second phase, and ionic polarizability on dielectric constant (εr) were investigated. The quality factor (Q×f) varied with packing fraction that concerned the second phase. Moreover, the temperature coefficient of the resonant frequency (τf) was influenced by MgO6octahedral distortion and bond valence. Excellent dielectric properties of the CaMg1−xLi2xSi2O6ceramic was exhibited atx= 0.05 with εr= 7.44,Q×f= 41,017 GHz (f= 15.1638 GHz), and τf= −59.3 ppm/°C when sintered at 900 °C. It had a good application prospect in the field of low-temperature co-fired ceramic (LTCC) substrate and devices.
An open-source library for hydrodynamic simulation of marine structures
Authors: Miquel Sergi Escamilla i , Fonseca Ícaro Aragão , Gaspar Henrique Murilo , Vieira Daniel Prata 
Published: July 2020

AbstractThe work focuses on an open and collaborative approach for hydrodynamic simulations of multibody operations. It builds on Vessel.js, an existing web-based ship design library, by modeling the interaction between entities and creating multibody models able to output different responses. To develop the cases here studied, the simulations are decomposed into single elements to understand their behavior separately before making them interact with other elements to create a multibody simulation. In the process, different hydrodynamic models are used to analyze the bodies according to the requirements of the simulations and the needed level of complexity. The simulations are coded in JavaScript and visualized in a web environment, with the option of using external hydrodynamic analyzes, which in this work were exemplified using a commercial software that adopts the linear potential wave theory. The paper concludes with a discussion about future applications of methods and simulations.
Der Informationsgehalt von Indikatoren des Technologietransfers in peripheren Regionen
Authors: Pomp Caron , Zundel Stefan 
Published: July 2020

ZusammenfassungAn Hochschulen wird vermehrt die Erwartung herangetragen, einen Beitrag zu regionalen Wirtschaftsentwicklung zu leisten. In diesem Kontext, der oft als Teil der so genannten Third Mission angesehen wird, wird auch gefordert, Output und Wirkung des Technologietransfers auf die regionale Wirtschaft durch Indikatoren möglichst gut zu erfassen. Eine Literaturauswertung liefert eine Liste jener Indikatoren, die in der Literatur zu diesem Zweck häufig angeführt werden. Diese Indikatoren können den Erfolg von Transferleistungen aber nur beschränkt abbilden, weil es eine Vielzahl von intermittierenden Faktoren gibt, die die Wirkung einer Hochschule auf die sie umgebende regionale Wirtschaft beeinflussen. Darüber hinaus muss eine schwache Performance von Hochschulen im Technologietransfer in peripheren Regionen nicht die mangelnde Leistungsfähigkeit einer dieser Hochschule signalisieren. Dafür können auch strukturelle Bindungsprobleme zur umgebenden Region und die fehlende Absorptionsfähigkeit der regionalen Wirtschaft verantwortlich sein.
Oscillatory flow reactors for synthetic chemistry applications
Authors: Bianchi Pauline , Williams Jason D. , Kappe C. Oliver 
Published: July 2020

AbstractOscillatory flow reactors (OFRs) superimpose an oscillatory flow to the net movement through a flow reactor. OFRs have been engineered to enable improved mixing, excellent heat- and mass transfer and good plug flow character under a broad range of operating conditions. Such features render these reactors appealing, since they are suitable for reactions that require long residence times, improved mass transfer (such as in biphasic liquid-liquid systems) or to homogeneously suspend solid particles. Various OFR configurations, offering specific features, have been developed over the past two decades, with significant progress still being made. This review outlines the principles and recent advances in OFR technology and overviews the synthetic applications of OFRs for liquid-liquid and solid-liquid biphasic systems.
COVID-19: is it just a lung disease? A case-based review
Authors: Spuntarelli Valerio , Luciani M. , Bentivegna E. , Marini V. , Falangone F. , Conforti G. , Rachele E. S. , Martelletti P. 
Published: July 2020

AbstractDue to its extreme virulence, COVID-19 virus has rapidly spread, developing a severe pandemic. SARS-COV-2 mostly affected the respiratory tract, causing a severe acute lung failure. Although the infection of airways, COVID-19 can be associated with chronic and systemic damages still not so much known. The purpose of this research is to collect recent evidence in literature about systemic diseases caused by COVID-19. The format of the present article has features of a systematic case-based review (level of evidence), and it is structured as a case series report (patients of our COVID-19 Medicine Ward have been selected as cases). Data for this review have been selected systematically, taking evidence only from indexed journals and databases: PubMed, Scopus, MEDLINE, and Cochrane systems. Papers chosen included systematic reviews, case series, clinical cases, meta-analysis studies, and RCTs. We start collecting studies since 2003. The main keywords used were “COVID-19” “OR” “SARS” “OR” “SARS – COV 2” “AND” “systemic disease” / “nephropathy” / “cardiac pathology” / “central nervous system.” Clinical cases belong to our COVID-19 Medicine Ward. One of the most severe COVID-19 clinical presentations includes cardiovascular problems, like myocarditis, pericarditis, and acute hearth failure. Cytokine release syndrome caused by COVID-19 develops severe acute kidney failure. It is still unknown the way coronavirus damages the liver, brain, and reproductive system. Considering the majority of the new studies about this pathology, it issues that COVID-19 is considered to be a multi-organ disease.
Structure aware Runge–Kutta time stepping for spacetime tents
Authors: Gopalakrishnan Jay , Schöberl Joachim , Wintersteiger Christoph 
Published: July 2020

AbstractWe introduce a new class of Runge–Kutta type methods suitable for time stepping to propagate hyperbolic solutions within tent-shaped spacetime regions. Unlike standard Runge–Kutta methods, the new methods yield expected convergence properties when standard high order spatial (discontinuous Galerkin) discretizations are used. After presenting a derivation of nonstandard order conditions for these methods, we show numerical examples of nonlinear hyperbolic systems to demonstrate the optimal convergence rates. We also report on the discrete stability properties of these methods applied to linear hyperbolic equations.
Evaluation of initial progress to implement Common Metrics across the NIH Clinical and Translational Science Awards (CTSA) Consortium
Authors: Welch Lisa C. , Tomoaia-Cotisel Andrada , Noubary Farzad , Chang Hong , Mendel Peter , Parajulee Anshu , Fenwood-Hughes Marguerite , Etchegaray Jason M. , Qureshi Nabeel , Chandler Redonna , Selker Harry P. 
Published: July 2020

Abstract

Introduction:
The Clinical and Translational Science Awards (CTSA) Consortium, about 60 National Institutes of Health (NIH)-supported CTSA hubs at academic health care institutions nationwide, is charged with improving the clinical and translational research enterprise. Together with the NIH National Center for Advancing Translational Sciences (NCATS), the Consortium implemented Common Metrics and a shared performance improvement framework.

Methods:
Initial implementation across hubs was assessed using quantitative and qualitative methods over a 19-month period. The primary outcome was implementation of three Common Metrics and the performance improvement framework. Challenges and facilitators were elicited.

Results:
Among 59 hubs with data, all began implementing Common Metrics, but about one-third had completed all activities for three metrics within the study period. The vast majority of hubs computed metric results and undertook activities to understand performance. Differences in completion appeared in developing and carrying out performance improvement plans. Seven key factors affected progress: hub size and resources, hub prior experience with performance management, alignment of local context with needs of the Common Metrics implementation, hub authority in the local institutional structure, hub engagement (including CTSA Principal Investigator involvement), stakeholder engagement, and attending training and coaching.

Conclusions:
Implementing Common Metrics and performance improvement in a large network of research-focused organizations proved feasible but required substantial time and resources. Considerable heterogeneity across hubs in data systems, existing processes and personnel, organizational structures, and local priorities of home institutions created disparate experiences across hubs. Future metric-based performance management initiatives across heterogeneous local contexts should anticipate and account for these types of differences.
Development of a Medical Support Training Program for Disaster Management in Indonesia: A Hospital Disaster Medical Support Program for Indonesia
Authors: Kang Hui Min , Pek Jen Heng , Venkataraman Anantharaman 
Published: July 2020

AbstractDisasters are often unforeseen events. Hospitals form a critical component of any country’s disaster management medical support system. To ensure optimal operations, minimize chaos, and allow flexibility in response, planning and practice are crucial. Singapore Health Services (SingHealth) collaborated with Hasanuddin University (UnHas) in Makassar, Indonesia, to develop a Hospital Disaster Medical Support (HDMS) program for the province of South Sulawesi, Indonesia. An assessment of the needs of the hospitals in Makassar, Indonesia, for disaster preparedness was carried out. A curriculum for the HDMS program was developed based on the assessment. Discussions with stakeholders of various hospitals were held for the implementation of this program. A total of 310 participants were trained in this program over the two-year period. The feedback from the participants was positive. The exercises provided a more realistic simulation of the concepts of hospital management in a disaster situation. Up to 73 persons were also trained as program instructors during this period. The development of the cadre of instructors in hospital disaster medical support will likely help sustain the program for the next few years.
Early Miocene marsupialiforms, gymnures, and hedgehogs from Ribesalbes-Alcora Basin (Spain)
Authors: Crespo Vicente D. , Goin Francisco J. , Montoya Plini , Ruiz-Sánchez Francisco J. 
Published: July 2020

AbstractMaterials from the localities of Araia d'Alcora in the Ribesalbes-Alcora Basin (Spain, early Miocene, Biozone C, MN4) have yielded an assemblage of erinaceids and metatherians, relatively rich for an Iberian site. The most common erinaceid is the gymnureGalerix symeonidisiDoukas, 1986, present in almost all of the studied sites. Other erinaceids in the faunal list are possibly an indeterminate species of the generaLantanotheriumFilhol, 1888 andAtelerixPomel, 1848, in what constitutes one of their oldest occurrences in Europe. Metatherians are represented by the herpetotheriidAmphiperatherium frequens erkertshofense(Koenigswald, 1970). The material described here was partially published by Furió and colleagues in 2012. We complete it with new material from the known localities and with material from new sites. We describe for the first time the lower dentition of this taxon in this basin, thus increasing knowledge of the high variability of its decidual molars. In addition, the climatic preferences of the speciesA. frequens(von Meyer, 1846), which was probably less strict in its humidity requirements than previously thought, are also discussed.
EXPLORING THE GUALE VILLAGE AND SPANISH MISSION OCCUPATIONS AT THE SAPELO SHELL RING COMPLEX THROUGH BAYESIAN ANALYSIS
Authors: Thompson Victor D , Jefferies Richard W , Moore Christopher R 
Published: July 2020

ABSTRACTBayesian analysis of radiocarbon (14C) dates in North American archaeology is increasing, especially among archaeologists working in deeper time. However, historical archaeologists have been slow to embrace these new techniques, and there have been only a few examples of the incorporation of calendar dates as informative priors in Bayesian models in such work in the United States. To illustrate the value of Bayesian approaches to sites with both substantial earlier Native American occupations as well as a historic era European presence, we present the results of our Bayesian analysis of 14C dates from the earlier Guale village and the Mission period contexts from the Sapelo Shell Ring Complex (9MC23) in southern Georgia. Jefferies and Moore have explored the Spanish Mission period deposits at this site to better understand the Native American interactions with the Spanish during the 16th and 17th centuries along the Georgia Coast. Given the results of our Bayesian modeling, we can say with some degree of confidence that the deposits thus far excavated and sampled contain important information dating to the 17th-century mission on Sapelo Island. In addition, our modeling of new dates suggests the range of the pre-Mission era Guale village. Based on these new dates, we can now say with some degree of certainty which of the deposits sampled likely contain information that dates to one of the critical periods of Mission period research, the AD 1660–1684 period that ushered in the close of mission efforts on the Georgia Coast.
Therapy discontinuation in a primary care psychological service: why patients drop out
Authors: Ghaemian Aisan , Ghomi Mahdi , Wrightman Miles , Ellis-Nee Colm 
Published: July 2020

Abstract
The present study aimed to explore patients’ experience with an Improving Access to Psychological Therapies (IAPT) service, and to investigate the reasons for discontinuing their treatment. A qualitative approach was adopted using thematic analysis of semi-structured interviews carried out with 818 patients attending for treatment in Talking Change from November 2015 to January 2019, retrospectively. The five main themes that emerged from the study were: ‘Felt better’, ‘Issues with group settings’, ‘Therapeutic alliance breakdown’, ‘Miscommunication’ and ‘Impracticalities’. The qualitative study uncovered a wide range of reasons for people who had dropped out from their treatment. The findings mainly emphasised general dissatisfaction and inconvenient appointments. However, improvement in symptoms of depression and anxiety was also identified as a key factor among patients who discontinued their treatment. This recovery is known as ‘progress withdrawal’ in which patients withdraw from treatment early due to good therapeutic progress. We present clinical and procedural implications arising from these themes.

Key learning aims

(1)
To explore what can cause discontinuation of therapy.

(2)
To obtain the experience of people who have received treatment and dropped out from Talking Change Psychological Therapy services.

(3)
To explore whether people recovered as part of the treatment withdrawal and what may have helped towards that recovery.