bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segregating domain-general from emotional context-specific inhibitory control systems - ventral striatum and orbitofrontal cortex serve as emotion-cognition integration hubs
Authors: Zhuang Qian , Xu Lei , Zhou Feng , Yao Shuxia , Zheng Xiaoxiao , Zhou Xinqi , Li Jialin , Xu Xiaolei , Fu Meina , Li Keshuang , Vatansever Deniz , Kendrick Keith M. , Becker Benjamin 
Published: December 2020

AbstractInhibitory control hierarchically regulates cognitive and emotional systems in the service of adaptive goal-directed behavior across changing task demands and environments. While previous studies convergently determined the contribution of prefrontal-striatal systems to general inhibitory control, findings on the specific circuits that mediate the context-specific impact of inhibitory control remained inconclusive. Against this background we employed an evaluated emotional Go/No Go task with fMRI in a large cohort of subjects (N = 250) to segregate brain systems and circuits that mediate domain-general from emotion-specific inhibition control. Particularly during a positive emotional context, behavioral results showed a lower accuracy for No Go trials and a faster response time for Go trials. While the dorsal striatum and lateral frontal regions were involved in inhibitory control irrespective of emotional context, activity in the ventral striatum (VS) and medial orbitofrontal cortex (mOFC) varied as a function of emotional context. On the voxel-wise network level, limbic and striatal systems generally exhibited highest changes in global brain connectivity during inhibitory control, while global brain connectivity of the left mOFC was less suppressed during emotional contexts. Functional connectivity analyses moreover revealed that negative coupling between the VS with inferior frontal gyrus (IFG)/insula and mOFC varied as a function of emotional context. Together these findings indicated separable domain general systems as well emotional context-specific inhibitory brain systems which specifically encompass the VS and its connections with frontal regions.
Intense and Mild Wave of COVID-19 in The Gambia: a Cohort Analysis
Authors: Roca Anna ,   MRCG/GG COVID-19 working group
Published: December 2020

ABSTRACTBackgroundThe SARS-CoV-2 pandemic is evolving differently in Africa compared to other regions, with lower transmission and milder clinical presentation. Reasons for this are not fully understood. Recent data from Eastern and Southern Africa suggest that transmission may be higher than measured. Detailed epidemiological data in different African settings is urgently needed.MethodsWe calculated cumulative rates of SAR-CoV-2 infections per 1,000 people at risk in The Gambia (2.42 million individuals) using publicly available data. We evaluated these rates in a cohort of 1,366 employees working at the MRC Unit The Gambia @LSHTM (MRCG) where systematic surveillance of symptomatic cases and contact tracing was implemented. Cumulative rates among the Gambian population were stratified by age groups and, among MRCG staff, by occupational exposure risk. SARS-CoV-2 testing was conducted on oropharyngeal/nasopharyngeal samples with consistent sampling and laboratory procedures across cohorts.FindingsBy September 2020, 3,579 cases of SARS-CoV-2 and 115 deaths had been identified; with 67% of cases detected in August. Among them, 191 cases were MRCG staff; all of them were asymptomatic/mild, with no deaths. The cumulative incidence rate for SARS-CoV-2 infection among MRCG staff (excluding those with occupational exposure risk) was 129 per 1,000, at least 20-fold higher than the estimations based on diagnosed cases in the adult Gambian population.InterpretationOur findings are consistent with recent African sero-prevalence studies reporting high community transmission of SAR-CoV-2. Enhanced community surveillance is essential to further understand and predict the future trajectory of the pandemic in Africa.
SARS-CoV-2/COVID-19 hospitalised patients in Switzerland: a prospective cohort profile
Authors: Thiabaud Amaury , Iten Anne , Balmelli Carlo , Senn Laurence , Troillet Nicolas , Widmer Andreas , Flury Domenica , Schreiber Peter W. , Vázquez Miriam , Damonti Lauro , Buettcher Michael , Vuichard-Gysin Danielle , Kuhm Christoph , Cusini Alexia , Riedel Thomas , Nussbaumer Yvonne , Gaudenz Roman , Heininger Ulrich , Berger Christoph , Zucol Franziska , Bernhard-Stirnemann Sara , Corti Natascia , Zimmermann Petra , Uka Anita , Niederer-Loher Anita , Gardiol Céline , Roelens Maroussia , Keiser Olivia 
Published: December 2020

AbstractBackgroundSARS-CoV-2/COVID-19, which emerged in China in late 2019, rapidly spread across the world causing several million victims in 213 countries. Switzerland was severely hit by the virus, with 43’000 confirmed cases as of September 1st, 2020.AimIn cooperation with the Federal Office of Public Health, we set up a surveillance database in February 2020 to monitor hospitalised patients with COVID-19 in addition to their mandatory reporting system.MethodsPatients hospitalised for more than 24 hours with a positive PCR test, from 20 Swiss hospitals, are included. Data collection follows a custom Case Report Form based on WHO recommendations and adapted to local needs. Nosocomial infections were defined as infections for which the onset of symptoms started more than 5 days after the patient’s admission date.ResultsAs of September 1st, 2020, 3645 patients were included. Most patients were male (2168 - 59.5%),and aged between 50 and 89 years (2778 - 76.2%), with a median age of 68 (IQR 54-79). Community infections dominated with 3249 (89.0%) reports. Comorbidities were frequently reported: hypertension (1481 - 61.7%), cardiovascular diseases (948 - 39.5%), and diabetes (660 - 27.5%) being the most frequent in adults; respiratory diseases and asthma (4 −21.1%), haematological and oncological diseases (3 – 15.8%) being the most frequent in children. Complications occurred in 2679 (73.4%) episodes, mostly for respiratory diseases (2470 - 93.2% in adults, 16 – 55.2% in children), renal (681 – 25.7%) and cardiac (631 – 23.8%) complication for adults. The second and third most frequent complications in children affected the digestive system and the liver (7 - 24.1%). A targeted treatment was given in 1299 (35.6%) episodes, mostly with hydroxychloroquine (989 - 76.1%). Intensive care units stays were reported in 578 (15.8%) episodes. 527 (14.5%) deaths were registered, all among adults.ConclusionThe surveillance system has been successfully initiated and provides a very representative set of data for Switzerland. We therefore consider it to be a valuable addition to the existing mandatory reporting, providing more precise information on the epidemiology, risk factors, and clinical course of these cases.
First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain
Authors: Iftimie Simona , López-Azcona Ana F. , Vallverdú Immaculada , Hernàndez-Flix Salvador , de Febrer Gabriel , Parra Sandra , Hernández-Aguilera Anna , Riu Francesc , Joven Jorge , Camps Jordi , Castro Antoni ,   REUSCOVID Study Group
Published: December 2020

AbstractMany countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with a first wave during spring followed by the current second wave in late summer and autumn. Empirical data show that the characteristics of the effects of the virus do vary between the two periods. Differences in age range and severity of the disease have been reported, although the comparative characteristics of the two waves still remain largely unknown. Those characteristics are compared in this study using data from two equal periods of 3 and a half months. The first period, between 15th March and 30th June, corresponding to the entire first wave, and the second, between 1st July and 15th October, corresponding to part of the second wave, still present at the time of writing this article. Two hundred and four patients were hospitalized during the first period, and 264 during the second period. Patients in the second wave were younger and the duration of hospitalization and case fatality rate were lower than those in the first wave. In the second wave, there were more children, and pregnant and post-partum women. The most frequent signs and symptoms in both waves were fever, dyspnea, pneumonia, and cough, and the most relevant comorbidities were cardiovascular diseases, type 2 diabetes mellitus, and chronic neurological diseases. Patients from the second wave more frequently presented renal and gastrointestinal symptoms, were more often treated with non-invasive mechanical ventilation and corticoids, and less often with invasive mechanical ventilation, conventional oxygen therapy and anticoagulants. Several differences in mortality risk factors were also observed. These results might help to understand the characteristics of the second wave and the behaviour and danger of SARS-CoV-2 in the Mediterranean area and in Western Europe. Further studies are needed to confirm our findings.
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma
Authors: Ahmadi Mohsen , Mousavi Pegah , Saffarzadeh Negin , Hajiesmaeili Fatemeh , Habibipour Leila 
Published: December 2020

AbstractHypoxanthine phosphoribosyl transferase (HPRT1), as a salvage pathway enzyme, plays a crucial role in modulating the cell cycle and has been reported to be overexpressed in multiple cancers. Nevertheless, the relationship between theHPRT1and Head and Neck Squamous Cell Carcinomas (HNSCC) has not been investigated so far. We first evaluated the expression ofHPRT1at transcriptomic and proteomic levels in tumor and healthy control tissues and its clinical value using The Cancer Genome Atlas (TCGA), Human Protein Atlas, Kaplan-Meier Plotter databases, GSE107591, and quantitative real-time PCR analysis. Then, we employed the COSMIC and cBioPortal databases to assess the mutations of theHPRT1gene and their association with survival outcomes of patients with HNSCC. Finally, we performed the functional enrichment analysis forHPRT1co-expressed genes in HNSCC utilizing the Enrichr database. The mRNA and protein expressions ofHPRT1were significantly elevated in HNSCC compared with normal tissues. Besides, the upregulation ofHPRT1expression was correlated with age, sex, pathological stage, and histological grades of HNSCC patients. Moreover, the increased expression ofHPRT1in cancer tissues exhibited a strong capacity for being a promising biomarker for the diagnosis and prognosis of patients with HNSCC. The co-expressed genes ofHPRT1were mainly enriched in several cancer-related processes such as DNA replication and cell cycle. The present study demonstrated that the overexpression ofHPRT1is significantly correlated with the progression of HNSCC and may serve as a useful biomarker for the early detection and risk stratification of patients with HNSCC.
COVID-19 PREDICTION IN SOUTH AFRICA: ESTIMATING THE UNASCERTAINED CASES- THE HIDDEN PART OF THE EPIDEMIOLOGICAL ICEBERG
Authors: Gu Xuelin , Mukherjee Bhramar , Das Sonali , Datta Jyotishka 
Published: December 2020

SUMMARYUnderstanding the impact of non-pharmaceutical interventions as well as acscounting for the unascertained cases remain critical challenges for epidemiological models for understanding the transmission dynamics of COVID-19 spread. In this paper, we propose a new epidemiological model (eSEIRD) that extends the widely used epidemiological models such as extended Susceptible-Infected-Removed model (eSIR) and SAPHIRE (initially developed and used for analyzing data from Wuhan). We fit these models to the daily ascertained infected (and removed) cases from March 15, 2020 to Dec 31, 2020 in South Africa that reported the largest number of confirmed COVID-19 cases and deaths from the WHO African region. Using the eSEIRD model, the COVID-19 transmission dynamics in South Africa was characterized by the estimated basic reproduction number (R0) starting at 3.22 (95%CrI: [3.19, 3.23]) then dropping below 2 following a mandatory lockdown implementation and subsequently increasing to 3.27 (95%CrI: [3.27, 3.27]) by the end of 2020. The initial decrease of effective reproduction number followed by an increase suggest the effectiveness of early interventions and the combined effect of relaxing strict interventions and emergence of a new coronavirus variant in South Africa. The low estimated ascertainment rate was found to vary from 1.65% to 9.17% across models and time periods. The overall infection fatality ratio (IFR) was estimated as 0.06% (95%CrI: [0.04%, 0.22%]) accounting for unascertained cases and deaths while the reported case fatality ratio was 2.88% (95% CrI: [2.45%, 6.01%]). The models predict that from December 31, 2020, to April 1, 2021, the predicted cumulative number of infected would reach roughly 70% of total population in South Africa. Besides providing insights on the COVID-19 dynamics in South Africa, we develop powerful forecasting tools that enable estimation of ascertainment rates and IFR while quantifying the effect of intervention measures on COVID-19 spread.AMS ClassificationPlace Classification here. Leave as is, if there is no classification
How accurate are citations of frequently cited papers in biomedical literature?
Authors: Pavlovic V , Weissgerber T , Stanisavljevic D , Pekmezovic T , Garovic V , Milic N ,   CITE Investigators
Published: December 2020

AbstractCitations are an important, but often overlooked, part of every scientific paper. They allow the reader to trace the flow of evidence, serving as a gateway to relevant literature. Most scientists are aware of citations errors, but few appreciate the prevalence or consequences of these problems. The purpose of this study was to examine how often frequently cited papers in biomedical scientific literature are cited inaccurately. The study included an active participation of first authors of frequently cited papers; to first-hand verify the citations accuracy. The approach was to determine most cited original articles and their parent authors, that could be able to access, and identify, collect and review all citations of their original work. Findings from feasibility study, where we collected and reviewed 1,540 articles containing 2,526 citations of 14 most cited articles in which the 1stauthors were affiliated with the Faculty of Medicine University of Belgrade, were further evaluated for external confirmation in an independent verification set of articles. Verification set included 4,912 citations identified in 2,995 articles that cited 13 most cited articles published by authors affiliated with the Mayo Clinic Division of Nephrology and Hypertension (Rochester, Minnesota, USA), whose research focus is hypertension and peripheral vascular disease. Most cited articles and their citations were determined according to SCOPUS database search. A citation was defined as being accurate if the cited article supported or was in accordance with the statement by citing authors. A multilevel regression model for binary data was used to determine predictors of inaccurate citations. At least one inaccurate citation was found in 11% and 15% of articles in the feasibility study and verification set, respectively, suggesting that inaccurate citations are common in biomedical literature. The main findings were similar in both sets. The most common problem was the citation of nonexistent findings (38.4%), followed by an incorrect interpretation of findings (15.4%). One fifth of inaccurate citations were due to “chains of inaccurate citations,” in which inaccurate citations appeared to have been copied from previous papers. Reviews, longer time elapsed from publication to citation, and multiple citations were associated with higher chance of citation being inaccurate. Based on these findings, several actions that authors, mentors and journals can take to reduce citation inaccuracies and maintain the integrity of the scientific literature have been proposed.
Tensor description of X-ray magnetic dichroism at the Fe L
2,3-edges of Fe3O4
Authors: Elnaggar Hebatalla , Haverkort Maurits W. , Hamed Mai Hussein , Dhesi Sarnjeet S. , de Groot Frank M. F. 
Published: December 2020

A procedure to build the optical conductivity tensor that describes the full magneto-optical response of the system from experimental measurements is presented. Applied to the Fe L
2,3-edge of a 38.85 nm Fe3O4/SrTiO3 (001) thin-film, it is shown that the computed polarization dependence using the conductivity tensor is in excellent agreement with that experimentally measured. Furthermore, the magnetic field angular dependence is discussed using a set of fundamental spectra expanded on spherical harmonics. It is shown that the convergence of this expansion depends on the details of the ground state of the system in question and in particular on the valence-state spin–orbit coupling. While a cubic expansion up to the third order explains the angular-dependent X-ray magnetic linear dichroism of Fe3+ well, higher-order terms are required for Fe2+ when the orbital moment is not quenched.
Effects of service encounter barriers on situational abnormality and consumers' behavioral intentions at food and beverage restaurants
Authors: Akhtar Naeem , Siddiqi Umar Iqbal , Ahmad Wasim , Usman Muhammad , Chen Xianglan , Islam Tahir 
Published: December 2020

PurposeThe present study unveils the service encounter barriers – interactional and instructional – faced by foreign consumers at food and beverage restaurants in China. It builds a conceptual framework and examines (1) how service encounter barriers create situational abnormality, (2) how situational abnormality engenders foreign consumers' felt discomfort that influences their revisit intentions and (3) how expectations disconfirmation moderates situational abnormality.Design/methodology/approachConvenience sampling using the survey method was employed to collect data from 517 foreign consumers – who stay in Beijing (China) – at food and beverage restaurants. The study used IBM SPSS 25.0 and Amos Graphics 24.0 to analyze the data and interpret results.FindingsFindings reveal that interactional and instructional barriers positively create situational abnormality, which ultimately leads to foreign consumers' felt discomfort and their negative revisit intentions. Expectations disconfirmation significantly aggravates situational abnormality as a moderator.Research limitations/implicationsThis study investigates foreign consumers' behavior at food and beverage restaurants in China and cautions its generalizability. It suggests corroborating the foreign consumers' behavioral intentions in the context of other countries to generalize the findings and unleash other factors additive to comprehend their behavior in the wake of restaurant industry.Originality/valueThe extant literature has not examined the service encounter barriers faced by foreign consumers at food and beverage restaurants in China. The present study, responding to the previous calls, incorporated the service encounter barriers and their downstream effects on foreign consumers' behavioral responses. By doing so, it adds value to the domestic food and beverage restaurants and service firms in China, in particular, and paves the way to understand the interactional and instructional barriers in the global context, in general, by engaging the foreign consumers.
A study of performance measures and quality management system in small and medium enterprises in India
Authors: Bagodi Virupaxi , Thimmappa Venkatesh Sreenath , Sinha Deepankar 
Published: December 2020

PurposeThe paper aims to identify causality amongst small and medium enterprises' (SMEs') performance indicators, propose an integrated index of business performance and quality practices and investigate the effect of quality management system (QMS) on business performance.Design/methodology/approachThis study proposes a two-stage approach. In the first stage, the authors gathered responses with a questionnaire on variables affecting business performance and identified dimensions using exploratory and confirmatory factor analyses. Path analysis was carried out to identify causality between the dimensions. In the next stage, the validation of stage 1 findings was carried out to substantiate the proposition that QMS affects performance. Questionnaire survey and in-depth interviews were conducted during the second stage. The analysis was done following the case study protocol – within- and cross-case analysis and validated with supportive and conflicting literature.FindingsThe results show that the employee – dimension is crucial to process effectiveness, customer satisfaction and finances. Customer satisfaction results from employee satisfaction and processes. QMS impacts processes and employee performance, thus establishes the causality between business performance factors and QMS. QMS impacts finances in the short run but yields long-term benefits and is dependent on two factors – degree of knowledge of quality practices and its application in business.Originality/valueThis study reveals the performance dimensions of SMEs, their causality and the impact of QMS on performance. It suggests a shift from traditional approaches, correcting defects using statistical quality control approaches, to a sustainable growth path – a long-term approach. This study puts forward two associated indices – the business performance and the knowledge of quality practices and its application index.
Evaluating the economic and social benefits of multiutility tunnels with an agent-based simulation approach
Authors: Wu Chengke , Wu Peng , Jiang Rui , Wang Jun , Wang Xiangyu , Wan Ming 
Published: December 2020

PurposeMultiutility tunnel (MUT) has been recognised as a more sustainable method to place underground utilities than the traditional directly buried (DB) method. However, the implementation of MUT is hindered because of high initial construction costs and the difficulty to demonstrate its benefits, especially social benefits that are hard to be quantified. To address the limitation, this paper aims to quantify and compare both economic costs and traveller loss (i.e. an important part of social costs) of the MUT and DB method.Design/methodology/approachAn agent-based model (ABM) is developed, which considers attributes and actions of vehicles, interactions between vehicles and interactions between vehicles and the road network. The ABM is used to estimate traveller loss by comparing traveller time when the MUT and DB method is adopted, respectively. The traveller loss is combined with economic costs to estimate and compare the LCC of the MUT and DB method. To verify the ABM-based approach, it is implemented in an MUT project in Shanghai, China.FindingsResults of the study indicate: (1) When the DB method is adopted, periodic E&Rs cause severe traffic congestion and substantial traveller loss. (2) When traveller loss is not included in the LCC estimation, the DB method has a lower LCC in most scenarios. (3) When traveller loss is included, the relative LCC of MUT and the time it takes to cover the LCC of the MUT and DB method is largely reduced. Thus, when social costs are considered, MUT will bring more benefits than the DB method.Originality/valuePrevious studies on comparing the MUT and DB method focus on investigating economic costs, while other costs, e.g. social costs, are not well addressed quantitatively. Besides, current studies of traveller loss estimation lack consideration of factors such as unique attributes, actions and interactions of vehicles and the network. Hence, this paper applies an ABM-based approach to involve these factors and produce more reliable estimation of traveller loss than existing approaches. Moreover, by integrating traveller loss into LCC analysis, this paper helps to understand the benefits of MUT thus assisting decision-making in selecting utilities placement methods.