bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of Skeletal Staging in Chondrosarcoma of Bone: Results of Survey on Current Practices Among Musculoskeletal Oncologists
Authors: Gulia Ashish , Gupta Srinath , Kurisunkal Vineet , Puri Ajay 
Published: October 2020

Abstract

Purpose
There are no clear guidelines for staging of conventional chondrosarcoma. We conducted an online survey to determine the current practices for skeletal staging for conventional chondrosarcoma among practicing oncologists and to assess any discrepancy in practices and with the published literature.

Methodology
A simple ten-question online survey (e-mails and WhatsApp) was conducted among practicing oncologists over a period of 3 weeks using online portal (surveymonkey.com). It was followed by analysis based on each question to find current practices.

Results
139 members participated in the survey (84% surgeons, 9% radiologists, 3% medical and 3% radiation oncologists and 1% nuclear medicine). 65% have been treating chondrosarcoma for more than 5 years. 88% opined that biopsy is mandatory even if the radiology is suggestive of a chondrosarcoma. 66% said that solitary skeletal metastasis is seen in less than 2% of the cases but 84% of participants were in favour of performing an investigation (bone scan/PET scan) for skeletal survey. While 43% opined skeletal metastasis is more common in recurrent chondrosarcoma, 26% said that performing a bone scan was likely to impact management, 28% said it will not impact management and 46% were unsure. Of the group who thought that a bone scan would impact management or were unsure, the majority (56%) opined that this was relevant only in grade 2 and grade 3 chondrosarcoma.

Conclusion
There was lack of consensus regarding staging for chondrosarcoma. Only 26% of respondents were convinced that performing a bone scan was likely to impact management of chondrosarcoma. There is a need to analyze large data sets (retrospective/prospective) to arrive at an evidence-based staging algorithm for chondrosarcoma.
The High Flex Total Knee Arthroplasty—Higher Incidence of Aseptic Loosening and No Benefit in Comparison to Conventional Total Knee Arthroplasty: Minimum 16-Years Follow-Up Results
Authors: Radetzki Florian , Zeh Alexander , Delank Karl-Stefan , Wohlrab David 
Published: October 2020

Abstract
Purpose
This prospective randomized study compares the clinical and radiographic long-term results at least 16 years after total knee arthroplasty (TKA) between a mobile-bearing high flex and a fixed-bearing posterior-stabilized knee.

Methods
In 2000, we included 60 patients who underwent a TKA. Patients were divided into two groups. At the time of the follow-up after a minimum of 16 years (16.5 years ± 0.6), 16 patients had died for causes unrelated to the operation, 15 were lost to the follow-up. Five patients of the high flex group had a revision. The final evaluation included the hospital for special surgery score (HSS) and radiographs. Using the X-rays and the Knee Society Roentgenographic Evaluation and Scoring System, radiolucent lines and the maximal knee flexion were determined.

Results
No significant differences between the two groups were found. The mean HSS score of LPS group patients was 87.9 (± 10.6) points and that of the high flex group was 93.1 (± 7.4) points. Five patients of the high flex group had undergone a reoperation. One knee was revised for painful mid-flexion instability and the others for symptomatic aseptic loosening of the components.

Conclusion
The long-term follow-up does not show any clear benefits and even a higher incidence of implant loosening using the mobile-bearing high-flex knee.
Acceptability and willingness to participate in the Tailored Activity Program: perceptions of people living with dementia, their care partners and health professionals
Authors: Bennett Sally , Travers Catherine , Liddle Jacki , Smith Sandra , Clemson Lindy , O’Reilly Maria , Allen Michelle , Laver Kate , Beattie Elizabeth , Low Lee-Fay , O’Connor Claire , Gitlin Laura N. 
Published: October 2020

AbstractObjectives:The Tailored Activity Program (TAP) is an evidence-based occupational therapist-led intervention for people living with dementia and their care partners at home, developed in the USA. This study sought to understand its acceptability to people living with dementia, their care partners, and health professionals, and factors that might influence willingness to participate prior to its implementation in Australia.Methods:This study used qualitative descriptive methods. Semi-structured interviews were conducted with people living with dementia in the community (n = 4), their care partners (n = 13), and health professionals (n = 12). People living with dementia were asked about health professionals coming to their home to help them engage in activities they enjoy, whereas care partners’ and health professionals’ perspectives of TAP were sought, after it was described to them. Interviews were conducted face-to-face or via telephone. All interviews were recorded and transcribed. Framework analysis was used to identify key themes.Results:Analysis identified four key themes labelled: (i) TAP sounds like a good idea; (ii) the importance of enjoyable activities; (iii) benefits for care partners; and (iv) weighing things up. Findings suggest the broad, conditional acceptability of TAP from care partners and health professionals, who also recognised challenges to its use. People living with dementia expressed willingness to receive help to continue engaging in enjoyable activities, if offered.Discussion:While TAP appeared generally acceptable, a number of barriers were identified that must be considered prior to, and during its implementation. This study may inform implementation of non-pharmacological interventions more broadly.
The psychological impacts of COVID-19: a study of frontline physicians and nurses in the Arab world
Authors: Al Mahyijari N. , Badahdah A. , Khamis F. 
Published: October 2020

Objectives:The COVID-19 (SARS-CoV2) pandemic is wreaking havoc on healthcare systems and causing serious economic, social, and psychological anguish around the globe. Healthcare workers (HCWs) who diagnose and care for COVID-19 patients have been shown to suffer burnout, stress, and anxiety.Methods:In this study, we collected data from 150 frontline HCWs who had close contact with COVID-19 patients at several health facilities in the Sultanate of Oman. The participants completed an online survey that included the Perceived Stress Scale, the Generalized Anxiety Disorder Scale, and the WHO-5 Well-Being Index.Results:The study found that a substantial number of healthcare professionals experienced relatively high levels of stress and anxiety, as well as suboptimal levels of well-being. Perceived stress and anxiety were significant predictors of HCWs’ well-being.Conclusions:This study adds to the increasing literature indicating harmful effects of COVID-19 on the mental health of HCWs.
A Study of Transmission Error Modeling and Preload Compensation for the Cable-Driven Sheaves Used in Space Docking Locks
Authors: Xu Chuntian , Li Jianguang , Wang Peng , Xu Zhengdong 
Published: October 2020

ABSTRACTThe transmission error of cable-driven sheaves (CDS) used in space docking locks directly affects the synchronous docking of two spacecraft, which is guaranteed mainly by the preload applied to their serial cables. But it is difficult controlled precisely because of the complicated cable deformation and operating conditions. The synchronous testing efficiency of the docking locks is inevitably influenced, correspondingly. This paper proposes a prediction model for the transmission error of CDS based on their cable deformation. In this model, the deformations of non- and free sectional cables are both modified on finite element analysis, which are respectively derived from classical Capstan equation and Hooke’s law for them without considering the effects of the friction coefficient between wire strands. Based on the proposed model, the relationships between the transmission error and dominating factors are analyzed. Then the preload compensation for transmission error is obtained at the engaging and locking angles of the docking locks, respectively. Experiments validate the model. This can provide a valuable reference in controlling the transmission error of CDS and improving the assembly efficiency of docking locks.
Health care and the spread of medical knowledge in the Portuguese empire, particularly the Estado da Índia (sixteenth to eighteenth centuries)
Authors: Abreu Laurinda 
Published: October 2020

AbstractThis article deals with the presence of physicians, surgeons and apothecaries in the early modern Portuguese empire and the dissemination of medical knowledge there. In Portugal itself, the health care sector had been the target of considerable royal interference since the final years of the fifteenth century, during the construction of the early modern state. Regulatory frameworks were established to harmonise health care practice throughout the country and to control the organisation and distribution of the available health care practitioners among local communities. As this was also the time when Portugal was investing heavily in its colonies, how were these policies reflected in the empire? Did health care feature in the Portuguese government’s colonial strategies? How did the official policy to send medical personnel overseas work on the ground? Did it operate at a large enough scale to transform local practices?
Middle Ordovician (Darriwilian) conodonts from southern Tibet, the Indian passive margin: implications for the age and correlation of the roof of the world
Authors: Stouge Svend , Harper David A. T. , Zhan Renbin , Liu Jianbo , Stemmerik Lars 
Published: October 2020

AbstractNew occurrences of middle–late Darriwilian (Middle Ordovician) conodonts are reported from the Nyalam region, southern Tibet. The conodont-yielding strata, referred to the Chiatsun Group, accumulated on the north Indian continental margin of northern Gondwana. These Middle Ordovician conodonts include the informal speciesHistiodellasp. A in the middle part of the Lower Formation of the Chiatsun Group succeeded by a fauna of thePygodus serraZone in the upper part of that formation.Pygodus anserinusis recorded from the base of the Upper Formation of the Chiatsun Group. The Nyalam succession and its conodont taxa allow for precise correlation of the strata preserved on top of Mount Qomolangma (Mount Everest), eastern Tibet and the Peri-Gondwana Lhasa (north central Tibet), South China, North China, Tarim Basin and Thailand-Malaysia (Sibumasu Terrane) terranes and/or microcontinents. The middle Darriwilian positive increase in δ13Ccarbvalues (carbon isotope excursion, or MDICE) is recorded from most terranes, and can be related to a late middle Darriwilian global short-term cooling and sea-level drop. The cooling event prompted temperate- to warm-water taxa to migrate towards the palaeoequator and constrained the Australasian Province to locations near and at the palaeoequator. The intensified oceanic circulation and upwelling on continental margins probably caused some characteristic taxa to become extinct. The incoming fauna was mainly of cool-water taxa. The conodont specimens from southern Tibet are black to pale grey, corresponding to conodont colour index (CAI) values of 5 to 6, which demonstrates that the host sedimentary rocks were once heated to more than 360°C.
First experiments on ICRF discharge generation by a W7-X-like antenna in the Uragan-2M stellarator
Authors: Moiseenko V. E. , Kovtun Yu. V. , Wauters T. , Goriaev A. , Lyssoivan A. I. , Lozin A. V. , Pavlichenko R. O. , Shapoval A. N. , Maznichenko S. M. , Korovin V. B. , Kramskoy E. D. , Kozulya M. M. , Zamanov N. V. , Siusko Y. V. , Krasiuk A. Yu. , Romanov V. S. , Alonso A. , Brakel R. , Dinklage A. , Hartmann D. , Kazakov Ye. , Laqua H. , Ongena J. , Stange T. ,   the Uragan-2M Team
Published: October 2020

In support of the ICRF experiments planned on the Wendelstein 7-X (W7-X) stellarator, i.e. fast ion generation, wall conditioning, target plasma production and heating, a first experimental study on plasma production has been made in the Uragan-2M (U-2M) stellarator using W7-X-like two-strap antenna. In all the experiments, antenna monopole phasing was used. The W7-X-like antenna operation with launched radiofrequency power of ~100 kW have been performed in helium (p = (4–14) × 10−2 Pa) with the vacuum vessel walls pre-loaded with hydrogen. Production of plasma with a density higher than 1012 cm−3 was observed near the first harmonic of the hydrogen cyclotron frequency. Operation at first hydrogen harmonic is feasible in W7-X future ICRF experiments.
“An Inevitable Consequence:” Changing Ideas of Prevention in the Wake of Catastrophic Events
Authors: SPEZIO TERESA SABOL 
Published: October 2020

AbstractIn the face of technology failures in preventing oil from reaching beaches and coasts after catastrophic oil spills in the 1960s and early 1970s, the oil industry and governmental officials needed to quickly reconsider their idea of prevention. Initially, prevention meant stopping spilled oil from coating beaches and coasts. Exploring the presentations at three oil-spill conferences in 1969, 1971 and 1973, this idea of prevention changed as the technological optimism of finding effective methods met the realities of oil-spill cleanup. By 1973, prevention meant stopping oil spills before they happened. This rapid policy transformation came about because the oil industry could not hide the visual evidence of the source of their technology failures. In this century, as policymakers confront invisible pollutants such as pesticides and greenhouse gases, considering ways to visually show the source of the pollution along with the effects could quicken policy decisions.
Dose–response association between sugar- and artificially sweetened beverage consumption and the risk of metabolic syndrome: a meta-analysis of population-based epidemiological studies
Authors: Zhang Xiao , Li Xi , Liu Leilei , Hong Feng , Zhao Huan , Chen Lulu , Zhang Jun , Jiang Yuexu , Zhang Jiangping , Luo Peng 
Published: October 2020

AbstractObjective:The associations between sugar-sweetened beverage (SSB) and artificially sweetened beverage (ASB) consumption and the risk of metabolic syndrome (MetS) remain controversial. A quantitative assessment of dose–response associations has not been reported. This study aims to assess the associations between the risk of MetS and SSB, ASB, and total sweetened beverage (TSB, the combination of SSB and ASB) consumption by reviewing population-based epidemiological studies.Design:Meta-analysis.Setting:We searched PubMed, Embase and Web of Science databases prior to 4 November 2019, for relevant studies investigating the SSB–MetS and ASB–MetS associations. A random effects model was used to estimate pooled relative risks (RR) and 95 % CI. Dose–response association was assessed using a restricted cubic splines model.Participants:We identified seventeen articles (twenty-four studies, including 93 095 participants and 20 749 MetS patients).Results:The pooled RR for the risk of MetS were 1·51 (95 % CI 1·34, 1·69), 1·56 (1·32, 1·83) and 1·44 (1·19, 1·75) in high consumption group of TSB, SSB and ASB, respectively; and 1·20 (1·13, 1·28), 1·19 (1·11, 1·28) and 1·31 (1·05, 1·65) per 250 ml/d increase in TSB, SSB and ASB consumption, respectively. Additionally, we found evidence of non-linear, TSB–MetS and SSB–MetS dose–response associations and a linear ASB–MetS dose–response association.Conclusions:TSB, SSB and ASB consumption was associated with the risk of MetS. The present findings provide evidence that supports reducing intake of these beverages to lower the TSB-, SSB- and ASB-related risk of MetS.
Associations between family structure and adolescents’ food habits
Authors: Fismen Anne-Siri , Smith Otto Robert Frans , Samdal Oddrun , Helleve Arnfinn , Haug Ellen 
Published: October 2020

AbstractObjective:To investigate family structure differences in adolescents’ consumption of fruit, vegetables, sweets and sugar-added soft drinks with adjustments for socio-demographic and socio-economic variables.Design:Cross-sectional data from the Health Behaviour in School-aged Children survey.Setting:Norwegian primary and secondary schools.Participants:Adolescents (n 4475) aged 11, 13, 15 and 16 years.Results:After adjusting for covariates, living in a single-mother family was associated with lower vegetable consumption (OR 0·76, 95 % CI 0·63, 0·91) and higher soft drink consumption (OR 1·29, 95 % CI 1·06, 1·57). Living in a mother and stepfather family was negatively associated with fruit (OR 0·71, 95 % CI 0·54, 0·95) and vegetable (OR 0·72, 95 % CI 0·54, 0·97) consumption. Living in a single-father family was associated with lower sweets consumption (OR 0·48, 95 % CI 0·32, 0·72). No significant interactions were demonstrated between family structure and socio-demographic or socio-economic covariates.Conclusions:The study suggests that an independent association between family structure and adolescents’ food habits exists.
Beyond state capacity: bureaucratic performance, policy implementation and reform
Authors: Williams Martin J. 
Published: October 2020

AbstractThere is a broad consensus that state capacity is central to economic and institutional development. But while the concept originated as a tool for macro-historical and comparative analysis, its success has led the term ‘capacity’ to become a default metaphor for discussing the quality of government bureaucracies. This paper discusses the limitations to conceiving of narrower questions of bureaucratic performance and policy implementation through the lens of the broad, aggregate concept of capacity. Whereas capacity refers to bureaucracies' hypothetical potential, this usually differs from their actual actions due to internal information and incentive problems created by bureaucracies' collective nature, and the constraints and uncertainty imposed by their multiple political principals. Capacity is a convenient shorthand term and is appropriate for some purposes, but it achieves this convenience by abstracting away from the mechanisms that determine bureaucratic performance and policy implementation. To advance the study of bureaucratic quality, researchers should seek to understand the implications of bureaucracies' collective nature, engage with contextual specificity and contingency in policy implementation, and focus measurement and reform efforts more towards actual performance than hypothetical capacity.
RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis
Authors: Lee Sun Hee , Hyeon Do Young , Yoon Soo-Hyun , Jeong Ji-Hak , Han Saeng-Myung , Jang Ju-Won , Nguyen Minh Phuong , Chi Xin-Zi , An Sojin , Hyun Kyung-gi , Jung Hee-Jung , Song Ji-Joon , Bae Suk-Chul , Kim Woo-Ho , Hwang Daehee , Lee You Mie 
Published: October 2020

AbstractInactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational modifications (PTM)-based mechanism for the inactivation of RUNX3 under hypoxia is still not fully understood. Here, we demonstrate a mechanism that G9a, lysine-specific methyltransferase (KMT), modulates RUNX3 through PTM under hypoxia. Hypoxia significantly increased G9a protein level and G9a interacted with RUNX3 Runt domain, which led to increased methylation of RUNX3 at K129 and K171. This methylation inactivated transactivation activity of RUNX3 by reducing interactions with CBFβ and p300 cofactors, as well as reducing acetylation of RUNX3 by p300, which is involved in nucleocytoplasmic transport by importin-α1. G9a-mediated methylation of RUNX3 under hypoxia promotes cancer cell proliferation by increasing cell cycle or cell division, while suppresses immune response and apoptosis, thereby promoting tumor growth during early tumorigenesis. Our results demonstrate the molecular mechanism of RUNX3 inactivation by G9a-mediated methylation for cell proliferation and antiapoptosis under hypoxia, which can be a therapeutic or preventive target to control tumor growth during early tumorigenesis.
Therapeutic effect of a histone demethylase inhibitor in Parkinson’s disease
Authors: Mu Ming-Dao , Qian Zhong-Ming , Yang Sheng-Xi , Rong Kang-Lin , Yung Wing-Ho , Ke Ya 
Published: October 2020

AbstractIron accumulation in the substantia nigra is recognized as a hallmark of Parkinson’s disease (PD). Therefore, reducing accumulated iron and associated oxidative stress is considered a promising therapeutic strategy for PD. However, current iron chelators have poor membrane permeability and lack cell-type specificity. Here we identified GSK-J4, a histone demethylase inhibitor with the ability to cross blood brain barrier, as a potent iron suppressor. Only a trace amount of GSK-J4 significantly and selectively reduced intracellular labile iron in dopaminergic neurons, and suppressed H2O2 and 6-OHDA-induced cell death in vitro. The iron-suppressive effect was mainly mediated by inducing an increase in the expression of the iron exporter ferroportin-1. In parallel, GSK-J4 rescued dopaminergic neuron loss and motor defects in 6-OHDA-induced PD rats, which was accompanied by reduction of oxidative stress. Importantly, GSK-J4 rescued the abnormal changes of histone methylation, H3K4me3 and H3K27me3 during 6-OHDA treatment although the iron-suppressive and neuroprotective effects were sensitive to H3K4me3 inhibition only. Also, upregulating H3K4me3 increased ferroportin-1 expression and neuroprotection. Taken together, we demonstrate a previously unappreciated action of GSK-J4 on cell-specific iron suppression and neuroprotection via epigenetic mechanism. Compared with conventional iron chelators, this compound has a stronger therapeutic potential for PD.
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury
Authors: Ding Chenguang , Ding Xiaoming , Zheng Jin , Wang Bo , Li Yang , Xiang Heli , Dou Meng , Qiao Yuxi , Tian Puxun , Xue Wujun 
Published: October 2020

AbstractRenal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R) kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases. However, the underlying molecular mechanisms related to ferroptosis in renal I/R injury remain unclear. In the present study, we investigated the regulatory role of microRNAs on ferroptosis in I/R-induced renal injury. We established the I/R-induced renal injury model in rats, and H/R induced HK-2 cells injury in vitro. CCK-8 was used to measure cell viability. Fe2+ and ROS levels were assayed to evaluate the activation of ferroptosis. We performed RNA sequencing to profile the miRNAs expression in H/R-induced injury and ferroptosis. Western blot analysis was used to detect the protein expression. qRT-PCR was used to detect the mRNA and miRNA levels in cells and tissues. We further used luciferase reporter assay to verify the direct targeting effect of miRNA. We found that ischemia/reperfusion-induced ferroptosis in rat’s kidney. We identified that miR-182-5p and miR-378a-3p were upregulated in the ferroptosis and H/R-induced injury, and correlates reversely with glutathione peroxidases 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) expression in renal I/R injury tissues, respectively. In vitro studies showed that miR-182-5p and miR-378a-3p induced ferroptosis in cells. We further found that miR-182-5p and miR-378a-3p regulated the expression of GPX4 and SLC7A11 negatively by directly binding to the 3′UTR of GPX4 and SLC7A11 mRNA. In vivo study showed that silencing miR-182-5p and miR-378a-3p alleviated the I/R-induced renal injury in rats. In conclusion, we demonstrated that I/R induced upregulation of miR-182-5p and miR-378a-3p, leading to activation of ferroptosis in renal injury through downregulation of GPX4 and SLC7A11.