bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct oral anticoagulants (DOAC) for prevention of recurrent arterial or venous thromboembolic events (ATE/VTE) in myeloproliferative neoplasms
Authors: Huenerbein Karlo , Sadjadian Parvis , Becker Tatjana , Kolatzki Vera , Deventer Eva , Engelhardt Carina , Griesshammer Martin , Wille Kai 
Published: November 2020

AbstractIn patients with BCR-ABL-negative myeloproliferative neoplasms (MPN), arterial or venous thromboembolic events (ATE/VTE) are a major burden. In order to control these complications, vitamin K antagonists (VKA) are widely used. There is no robust evidence supporting the use of direct oral anticoagulants (DOAC) in MPN patients. We therefore compared the efficacy and safety of both anticoagulants in 71 cases from a cohort of 782 MPN patients. Seventy-one of 782 MPN patients (9.1%) had ATE/VTE with nine ATE (12.7%) and 62 VTE (87.3%). Forty-five of 71 ATE/VTE (63.4%) were treated with VKA and 26 (36.6%) with DOAC. The duration of anticoagulation therapy (p = 0.984), the number of patients receiving additional aspirin (p = 1.0), and the proportion of patients receiving cytoreductive therapy (p = 0.807) did not differ significantly between the VKA and DOAC groups. During anticoagulation therapy, significantly more relapses occurred under VKA (n = 16) compared to DOAC treatment (n = 0, p = 0.0003). However, during the entire observation period of median 3.2 years (0.1–20.4), ATE/VTE relapse-free survival (p = 0.2) did not differ significantly between the two anticoagulants. For all bleeding events (p = 0.516) or major bleeding (p = 1.0), no significant differences were observed between VKA and DOAC. In our experience, the use of DOAC was as effective and safe as VKA, possibly even potentially beneficial with a lower number of recurrences and no increased risk for bleedings. However, further and larger studies are required before DOAC can be routinely used in MPN patients.
Experimental study of confined coaxial jets in a non-axisymmetric co-flow
Authors: Larsson I. A. Sofia , Lycksam Henrik , Lundström T. Staffan , Marjavaara B. Daniel 
Published: November 2020

Abstract
Confined, turbulent, coaxial jets in a non-axisymmetric co-flow are studied using particle image velocimetry (PIV) and planar laser-induced fluorescence (PLIF) simultaneously. Eight different cases are measured. Two momentum flow ratios of the co-flow are used in the experiment to investigate the effect on the coaxial burner jet behavior and mixing characteristics of the coaxial jet flow and the co-flowing, secondary fluid. In addition, four different momentum flow ratios of the coaxial outer to inner jet are investigated. The objective of the study is to get a deeper understanding of how the flow dynamics affects the entrainment and mixing process in a coaxial jet with a non-axisymmetric, surrounding co-flow. The results show that the introduction of a coaxial stream affects the inner jet and decreases the mixing with the surrounding co-flow; the effect is enhanced as the momentum flow ratio of the coaxial jet increases. The distribution of the secondary, co-flowing fluid controls the shape and direction of the coaxial jet, but does not have a significant impact on the mixing process near the centerline. Practical implications of this investigation are related to the possibility to better control a diffusion flame by introducing a coaxial stream. In this context it is concluded that it is possible to affect the jet development and hence the flame length. The conclusion is based on the assumption that the outer, coaxial stream has a low mass flow, not enough to provide complete combustion, and hence the co-flowing, secondary fluid provides the air needed for the combustion process.

Graphic abstract
Efficacy and safety of an adsorbent and anti-oxidative vaginal gel on CIN1 and 2, on high-risk HPV, and on p16/Ki-67: a randomized controlled trial
Authors: Major Attila Louis , Dvořák Vladimír , Schwarzová Jana , Skřivánek Aleš , Malík Tomáš , Pluta Marek , Mayboroda Ivanna , Grandjean Etienne Marc 
Published: November 2020

Abstract
Purpose
The effect of SAM vaginal gel, a medical device containing adsorptive silicon dioxide and antioxidative sodium selenite and citric acid, on histologically-proven cervical intraepithelial neoplasia type 2 (CIN2) as well as p16 positive CIN1, and on the presence of the onco-marker p16 was investigated.

Methods
216 women aged 25–60 years were randomized to either receive an intravaginal daily dose of SAM gel for three 28-day periods, or be followed-up without intervention. The primary endpoint was efficacy, defined as a combined histological and cytological regression. At baseline and after 3 months participants had: a guided biopsy including p16 immunohistochemical (IHC) staining, only if a lesion was visible at colposcopy; a cervical smear for cytology, high-risk human papillomavirus (hr-HPV) and a p16/Ki-67 test. At 6 months a further cytology and p16/Ki-67 test was performed.

Results
Regression of CIN lesions was observed in 78 out of 108 patients (72.2%) in the SAM gel arm and in 27 out of 108 patients (25.0%) in the control arm. Similarly, the change in the p16/Ki-67 cytological test status was significantly in favor of the treatment arm. The prevalence of hr-HPV decreased significantly (p < 0.001) in the treatment arm, from 87.0% to 39.8%, while it slightly increased in the control arm, from 78.7% to 83.3%. At 6 months the cytological regression in the treatment group and the highly significant effect on p16/Ki-67 was still present.

Conclusion
SAM vaginal gel enhances the regression of cervical lesions and clears hr-HPV and p16/Ki-67 in smears significantly, thus offering an active non-destructive management to prevent cervical cancer.

Trial registration number
ISRCTN11009040, date of registration: 10/12/2019; https://doi.org/10.1186/ISRCTN11009040; retrospectively registered.
High seroprevalence of feline morbilliviruses in free-roaming domestic cats in Chile
Authors: Busch Johannes , Sacristán Irene , Cevidanes Aitor , Millán Javier , Vahlenkamp Thomas W. , Napolitano Constanza , Sieg Michael 
Published: November 2020

AbstractFeline morbillivirus infections have gained increased attention due to repeated reports of their association with urinary tract disease in cats. In the present study, 112 serum samples from free-roaming domestic cats in Chile were tested for antibodies against feline morbillivirus genotypes 1 and 2 (FeMV-1 and FeMV-2) using an indirect immunofluorescence assay. In total, 63% of the animals showed antibodies against one or both FeMV genotypes. Antibodies directed exclusively against FeMV-2 were significantly more prevalent in male cats. The correlation of sex and FeMV-2 infection might give insight into potential routes of transmission. We provide, for the first time, serological data on FeMV in Chile.
The “impossible” rectal anastomosis: a novel use for endoluminal vacuum-assisted therapy
Authors: Lehwald-Tywuschik Nadja C. , Alexander Andrea , Alkhanji Nour , Flügen Georg , Fung Stephen , Rehders Alexander , Knoefel Wolfram Trudo 
Published: November 2020

Abstract
Purpose
Low rectal anastomoses can safely be performed, usually secured by a diverting ostomy. However, in cases of inflammation, extensive scarring, after extensive radiation, or after severe stapler dysfunction the risk for an anastomotic leak may become prohibitively high. We present a novel use for endoluminal vacuum-assisted therapy (EVAT) for otherwise “impossible” low rectal anastomoses.

Methods
Our initial series consisted of 14 consecutive patients who underwent prophylactic EVAT treatment due to unsafe low colorectal anastomosis. The vacuum sponge was placed intraoperatively in cases otherwise calling for a Hartmann’s procedure. An open-pored polyurethane sponge was placed prophylactically transanally for a mean duration of 11 days. Patient characteristics, complications, and risk factors were prospectively collected from medical records and analyzed.

Results
Between March 2017 and September 2019, we performed this novel technique in 14 patients enabling us to perform an anastomosis. Our collective consisted of 4 female (29%) and 10 male (71%) patients with a medium age of 59 years. Underlying disease was colorectal cancer in 10 patients, ovarian cancer, perforated sigmoid diverticulitis, ischemic colitis and sarcoma in one patient each. Dominant factors putting the anastomosis at extremely high risk were acute inflammation (n = 2), frozen pelvis (n = 2), intraoperative local chemotherapy (n = 2), stapler dysfunction (n = 2), non-closable rectal stump (n = 2), empty pelvis (n = 1) and ultra-low anastomosis (n = 3). Prophylactic EVAT was successful in 92% and gastrointestinal continuity was preserved in all patients.

Conclusion
This is the first description of prophylactic EVAT treatment. It seems to be a simple and safe method to enforce the high-risk low rectal anastomosis.
A hyperelastic model for simulating cells in flow
Authors: Müller Sebastian J. , Weigl Franziska , Bezold Carina , Bächer Christian , Albrecht Krystyna , Gekle Stephan 
Published: November 2020

AbstractIn the emerging field of 3D bioprinting, cell damage due to large deformations is considered a main cause for cell death and loss of functionality inside the printed construct. Those deformations, in turn, strongly depend on the mechano-elastic response of the cell to the hydrodynamic stresses experienced during printing. In this work, we present a numerical model to simulate the deformation of biological cells in arbitrary three-dimensional flows. We consider cells as an elastic continuum according to the hyperelastic Mooney–Rivlin model. We then employ force calculations on a tetrahedralized volume mesh. To calibrate our model, we perform a series of FluidFM$$^{{\textregistered }}$$

®

compression experiments with REF52 cells demonstrating that all three parameters of the Mooney–Rivlin model are required for a good description of the experimental data at very large deformations up to 80%. In addition, we validate the model by comparing to previous AFM experiments on bovine endothelial cells and artificial hydrogel particles. To investigate cell deformation in flow, we incorporate our model into Lattice Boltzmann simulations via an Immersed-Boundary algorithm. In linear shear flows, our model shows excellent agreement with analytical calculations and previous simulation data.
Trumps Wirtschaftspolitik und der Corona-Schock - Perspektiven für die USA
Authors: Welfens Paul J. J. 
Published: November 2020

ZusammenfassungUS-Präsident Donald Trump hat am 3. November 2020 zwar eine Niederlage erfahren, dennoch könnte der seit 2016 politisch in den USA herrschende Populismus als Mischung aus neuem Nationalismus und Protektionismus für einige Jahre andauern. Die US-Wahlen fanden unter besonderen Bedingungen statt: so löste der Corona-Schock einen weltweiten Wirtschaftsschock aus.
Ranging behaviour and habitat use in Montagu’s Harrier Circus pygargus in extensive farmland of Eastern Poland
Authors: Krupiński Dominik , Kotowska Dorota , Recio Mariano R. , Żmihorski Michał , Obłoza Przemysław , Mirski Paweł 
Published: November 2020

AbstractAgriculture intensification drives changes in bird populations but also in the space use by farmland species. Agriculture in Eastern Europe still follows an extensive farming model, but due to policy shifts aimed at rural restructuring and implementation of government subsidies for farmers, it is being rapidly intensified. Here, we aimed to document the ranging behaviour and habitat use of a declining farmland bird of prey—Montagu’s Harrier—and to compare it to findings from Western Europe. In 2011–2018, 50 individuals were followed with GPS loggers in Eastern Poland to study species spatial ecology. We found home ranges (kernel 90%) to be considerably large: 67.3 (± 42.3) km2 in case of males, but only 4.9 (± 6.1) km2 in females. Home ranges overlapped by 40%, on average, with other males in colonies and by 61%, on average, between consecutive breeding seasons of a particular male. The average daily distance travelled by males and females reached, respectively, 94.5 and 45.3 km, covering a daily home range of 32.3 and 3.1 km2. Individuals foraged up to 35 km from nests (3.5 km on average). Daily distance travelled and daily home ranges varied across the breeding season, in case of females being shortest in July, but sharply increasing in August. Also, individuals with breeding success had higher daily distance travelled but smaller daily home ranges. Average harriers’ distance to nest was generally increasing over the season, but was also changing over time of day: birds were closest to nest during night time, but at the end of the season, males roosted up to 16 km from the nest. While foraging males slightly preferred grasslands, higher elevation and smaller land-use patches, they avoided slopes and proximity of roads. We conclude that the surprisingly large home ranges of breeding harriers may suggest reduced prey availability or high fragmentation of hunting areas, both driving birds to utilise large areas and potentially contributing to population decline.
Farmers’ Perceptions as a Driver of Agricultural Practices: Understanding Soil Fertility Management Practices in Cocoa Agroforestry Systems in Cameroon
Authors: Kenfack Essougong Urcil P. , Slingerland Maja , Mathé Syndhia , Vanhove Wouter , Tata Ngome Precillia I. , Boudes Philippe , Giller Ken E. , Woittiez Lotte S. , Leeuwis Cees 
Published: November 2020

AbstractIn Africa, cocoa yields are low, partly due to soil fertility constraints and poor management. While peoples’ knowledge, aspirations, and abilities are key factors explaining their behaviour, little is known about the rationales that underpin soil fertility management practices (SFMPs) of cocoa farmers. To address this gap, we conducted an exploratory survey in two contrasting regions in Cameroon where cocoa is an important crop: the humid forest and the forest-savannah transition zone. Some 30% of farmers in the transition zone as opposed to 13% in the humid forest expressed concerns about soil fertility. The most relevant soil fertility indicators for farmers were high cocoa yield, dark soil colour, ease of tillage, and floral composition. To enhance and maintain soil fertility, farmers used residues from weeding (100%), planting of trees (42%), mineral fertilisers (33%), compost (16%), and manure (13%). More farmers in the transition zone than the humid forest implemented SFMPs. Our findings suggest that soil fertility perceptions, access to inputs, local practices, and experience influence farmers’ use of SFMPs. The limited use of mineral fertilisers was explained by poor access whereas the use of organic fertilisers and tree planting were mostly constrained by lack of labour and knowledge. Farmers prioritised practices to increase yield and viewed SFMPs to be the least important management practices, although they believe high cocoa yield is an important indicator of soil fertility. To foster sustainable cocoa intensification, it is necessary to enhance farmers’ knowledge on SFMPs, increase access to inputs, and ensure returns on investment while considering farmers’ priorities and practices.
‘My family’s goals are also my goals’: the relationship between collectivism, distal utility value, and learning and career goals of international university students in Germany
Authors: Mok Sog Yee , Bakaç Cafer , Froehlich Laura 
Published: November 2020

AbstractThe utility value of an academic task can affect university students’ learning behavior and career choices. For collectivistic-oriented students, learning and career goals also matter to their families. Following expectancy-value theory, we assumed that families’ achievement-related expectations would affect collectivistic-oriented students’ utility value. We conducted a survey study with 154 international university students in Germany. We found a significant mediation effect of students’ distal utility value of their university coursework on the relationship between students’ collectivism, learning goal orientation, and motivation to follow family-oriented distal career goals, respectively. Practical implications for career counselors and university teachers are discussed.
Development and clinical application of a preimplantation genetic testing for monogenic disease (PGT-M) for beta thalassemia in Vietnam
Authors: Mai Anh Dao , Harton Gary L. , Quang Vinh Nguyen , Van Huynh Nguyen , Thi Nhung Hoang , Thuy Nga Pham , Le Thi Thu Hien , Minh Duc Nguyen , Quoc Quan Tran 
Published: November 2020

Abstract
Purpose
The purpose of this research is to study the clinical outcomes using a next-generation sequencing-based protocol allowing for simultaneous testing of mutations in the beta thalassemia (HBB) gene, including single nucleotide polymorphism (SNP) markers for PGT-M along with low-pass whole genome analysis of chromosome aneuploidies for PGT-A.

Methods
A combined PGT-M (thalassemia) plus PGT-A system was developed for patients undergoing IVF in Vietnam. Here we developed a system for testing numerous thalassemia mutations plus SNP-based testing for backup mutation analysis and contamination control using next-generation sequencing (NGS). Low -pass next-generation sequencing was used to assess aneuploidy in some of the clinical PGT cases. Patients underwent IVF followed by embryo biopsy at the blastocyst stage for combined PGT-A/M.

Results
Two cases have completed the entire process including transfer of embryos, while a further nine cases have completed the IVF and PGT-M/A analysis but have not completed embryo transfer. In the two cases with embryo transfer, both patients achieved pregnancy with an unaffected, euploid embryo confirmed through prenatal diagnosis. In the further nine cases, 39 embryos were biopsied and all passed QC for amplification. There were 8 unaffected embryos, 31 carrier embryos, and 11 affected embryos. A subset of 24 embryos also had PGT-A analysis with 22 euploid embryos and 2 aneuploid embryos.

Conclusions
Here we report the development and clinical application of a combined PGT-M for HBB and PGT-A for gross chromosome aneuploidies from 11 patients with detailed laboratory findings along with 2 cases that have completed embryo transfer.
Identification-based predictive control of semi-active shock-absorbers for adaptive dynamic excitation mitigation
Authors: Graczykowski Cezary , Faraj Rami 
Published: November 2020

AbstractThe paper is aimed at detailed discussion of the Identification-based Predictive Control (IPC) developed for semi-active fluid-based shock-absorbers which protect structures and machines against impact excitations. The problem addressed is the optimal impact absorption providing adaptive mitigation of dynamic response of the mechanical system. The goal of applied control is dissipation of the entire impact energy and minimization of the impacting object deceleration during the process. Three proposed implementations of the IPC are based on sequentially repeated procedures, which include identification of excitation parameters and calculation of the valve opening providing minimization of tracking error of the optimal path. The presented numerical examples concerning mitigation of the dynamic excitation acting on the double-chamber pneumatic shock-absorber reveal high efficiency and prove robustness of the proposed control methods. The developed algorithms are compared against each other in terms of path-tracking efficiency and character of required control actions. The most important challenges in practical implementation of the proposed methods are indicated.
Two-dimensional nonlinear time fractional reaction–diffusion equation in application to sub-diffusion process of the multicomponent fluid in porous media
Authors: Pandey P. , Das S. , Craciun E-M. , Sadowski T. 
Published: November 2020

AbstractIn the present article, an efficient operational matrix based on the famous Laguerre polynomials is applied for the numerical solution of two-dimensional non-linear time fractional order reaction–diffusion equation. An operational matrix is constructed for fractional order differentiation and this operational matrix converts our proposed model into a system of non-linear algebraic equations through collocation which can be solved by using the Newton Iteration method. Assuming the surface layers are thermodynamically variant under some specified conditions, many insights and properties are deduced e.g., nonlocal diffusion equations and mass conservation of the binary species which are relevant to many engineering and physical problems. The salient features of present manuscript are finding the convergence analysis of the proposed scheme and also the validation and the exhibitions of effectiveness of the method using the order of convergence through the error analysis between the numerical solutions applying the proposed method and the analytical results for two existing problems. The prominent feature of the present article is the graphical presentations of the effect of reaction term on the behavior of solute profile of the considered model for different particular cases.
Conference proceedings publications in bibliographic databases: a case study of countries in Southeast Asia
Authors: Purnell Philip J. 
Published: November 2020

AbstractLeading citation databases have made concerted efforts to reflect academic conference contributions in the form of proceedings papers in their databases. We studied global trends and a regional case study to determine the relative representation of conference proceedings in the global scholarly literature using the Web of Science, Scopus, and Dimensions. We designed our case study of ten Southeast Asian countries to uncover conspicuous publishing patterns obscured by global average figures. As a result, we discovered that Indonesia alone has made a recent and remarkable shift towards conference proceedings publishing. This trend was not the result of expanding database coverage but may be linked to a rapid increase in conferences locally hosted in Indonesia. The conclusion suggests that conference proceedings are increasingly indexed by major databases, and that scholars might have found advantage in publishing conference papers that were quicker and easier to publish than journal articles or book chapters. Our study is relevant to policy makers in the area of research evaluation because it highlights potential changes in academic publishing behaviour by those being assessed.
Bayesianism and self-doubt
Authors: Bradley Darren 
Published: November 2020

AbstractHow should we respond to evidence when our evidence indicates that we are rationally impaired? I will defend a novel answer based on the analogy between self-doubt and memory loss. To believe that one is now impaired and previously was not is to believe that one’s epistemic position has deteriorated. Memory loss is also a form of epistemic deterioration. I argue that agents who suffer from epistemic deterioration should return to the priors they had at an earlier time. I develop this argument regarding memory loss then extend it to cases of self-doubt.