bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Two Commercially Available Fentanyl Screening Immunoassays for Clinical Use
Authors: Budelier Melissa M , Franks Caroline E , Logsdon Nicole , Jannetto Paul J , Scott Mitchell G , Roper Stephen M , Farnsworth Christopher W 
Published: February 2020

Abstract

Background
Fentanyl is a synthetic opioid associated with illicit drug use and overdose deaths. The SEFRIA Immunalysis (IAL) and ARK fentanyl assays are both FDA-cleared, open channel immunoassays for fentanyl detection in urine. However, limited data are available in the literature comparing these assays. The objective of this study was to perform a direct comparison of these two fentanyl immunoassays.

Methods
IAL and ARK fentanyl immunoassays were performed on a Roche Cobas e602 automated chemistry analyzer. Repeatability and total imprecision were compared by diluting fentanyl into urine at concentrations above, below, and at the manufacturers’ cutoffs of 1.0 ng/mL. Cross-reactivity was assessed for norfentanyl and the fentanyl analogs acetylfentanyl, acrylfentanyl, and furanylfentanyl. Concordance was assessed in 90 patient samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the gold standard.

Results
Repeatability varied from 11.4%–17.8% on the IAL assay and 2.8%–5.5% on the ARK assay. Total imprecision was 18.9%–40.7% on the IAL assay and 2.9%–6.4% on the ARK assay. Both assays cross-reacted with acetylfentanyl (∼100%), acrylfentanyl (∼100%), and furanylfentanyl (∼20%), but only the ARK assay cross-reacted with norfentanyl (∼3%). An admixture of 0.5 ng/mL fentanyl and 6 ng/mL norfentanyl produced a positive result on the ARK assay. Total concordance between IAL and ARK for 90 tested patient samples was 93% (kappa = 0.85). Relative to LC-MS/MS, the IAL assay had a concordance of 90% (kappa = 0.79) and the ARK assay had a concordance of 94% (kappa = 0.88). Including norfentanyl in the LC-MS/MS confirmation increased the concordance of the ARK to 96% (kappa = 0.90).

Conclusions
The ARK assay recognized the metabolite norfentanyl, demonstrated superior precision, and had better concordance with LC-MS/MS compared to the IAL assay.
How accurate is the medical record? A comparison of the physician’s note with a concealed audio recording in unannounced standardized patient encounters
Authors: Weiner Saul J , Wang Shiyuan , Kelly Brendan , Sharma Gunjan , Schwartz Alan 
Published: February 2020

AbstractObjectivesAccurate documentation in the medical record is essential for quality care; extensive documentation is required for reimbursement. At times, these 2 imperatives conflict. We explored the concordance of information documented in the medical record with a gold standard measure.Materials and MethodsWe compared 105 encounter notes to audio recordings covertly collected by unannounced standardized patients from 36 physicians, to identify discrepancies and estimate the reimbursement implications of billing the visit based on the note vs the care actually delivered.ResultsThere were 636 documentation errors, including 181 charted findings that did not take place, and 455 findings that were not charted. Ninety percent of notes contained at least 1 error. In 21 instances, the note justified a higher billing level than the gold standard audio recording, and in 4, it underrepresented the level of service (P = .005), resulting in 40 level 4 notes instead of the 23 justified based on the audio, a 74% inflated misrepresentation.DiscussionWhile one cannot generalize about specific error rates based on a relatively small sample of physicians exclusively within the Department of Veterans Affairs Health System, the magnitude of the findings raise fundamental concerns about the integrity of the current medical record documentation process as an actual representation of care, with implications for determining both quality and resource utilization.ConclusionThe medical record should not be assumed to reflect care delivered. Furthermore, errors of commission—documentation of services not actually provided—may inflate estimates of resource utilization.
TRIO Method for Detection of Beta-Lactams, Sulfonamides, and Tetracyclines in Raw Commingled Cows' Milk
Authors: Salter Robert S , Markovsky R J , Douglas D W , Saul S J , Tran A C , Legg D R , Schwartz J A , Conaway D M , McRobbie L W , Kalinowski Emily , Bulthaus Mary 
Published: February 2020

Abstract
A qualitative 3 min one-step assay for detecting beta-lactam, sulfonamide, and tetracycline antibiotics was validated following milk screening test guidelines developed by FDA-CVM, AOAC-RI, and IDF. The validated 90% detection levels with 95% confidence were: penicillin G 2 part per billion (ppb); amoxicillin 4 ppb; ampicillin 9 ppb; ceftiofur plus metabolites 50 ppb; cloxacillin 9 ppb; cephapirin 15 ppb; sulfadimethoxine 8 ppb; sulfamethazine 9 ppb; chlortetracycline 34 ppb; oxytetracycline 53 ppb; and tetracycline 42 ppb. Detection levels were lower than U.S. and Canadian allowable limits for milk and were consistent with most European Maximum Residue Limits. Tests of raw commingled cows’ milk indicated a low positive error rate of &lt;0.3% with no interferences demonstrated by 1.08 MM/mL somatic cells, Gram-positive or Gram-negative bacteria &lt; 300 K/mL, freeze/thawing, or non-targeted drugs. Detection of incurred residues were similar to, or more sensitive to, fortified samples. Some cross reactivity across drug families occurred in interference studies and therefore initial positive samples should be confirmed with drug family specific screening methods. The National Conference of Interstate Milk Shipments approval as a bulk tank/tanker screening test was completed in three stages for each drug family, including a tetracycline confirmation procedure to target U.S. tolerance levels. Detection and robustness were found to be appropriate for multiple countries’ regulatory requirements for screening tests. The method development, validation, and approval was intended to diversify and increase the verification tools for the control of the major antibiotic drug families used in managing cows’ health and welfare.
Closure of Persistent Tracheocutaneous Fistulas in Pediatric Burn Patients*
Authors: Camargo Lauren , Heiman Adee J , Ricci Joseph A 
Published: February 2020

Abstract
Tracheocutaneous fistula (TCF) is a common complication that occurs after decannulation of a long-term tracheostomy. Numerous studies have demonstrated the incidence of TCF formation to positively correlate with an increasing duration of cannulation, specifically in children. Treatment of a persistent TCF in a child has been well described in the literature, with good response to local measures such as curettage and silver nitrate. When this fails, fistulectomy followed by primary closure of the skin or secondary intention yields good results. However, there is a lack of knowledge on TCF formation in pediatric burn-injured patients, where a persistent TCF is a particularly challenging problem to correct given the paucity of supple tissue in the neck and potential for contractures after a large burn injury; effectively making the surgical repairs and management algorithms described in the available literature largely not applicable to this patient population. In this manuscript, we describe a series of pediatric burn patients with persistent TCF, successfully treated with a multilayered closure involving local tissue rearrangement in the form of medial mobilization of the strap muscles of the neck.
Birds of a Feather Feel Together: Emotional Ability Similarity in Consumer Interactions
Authors: Kidwell Blair , Lopez-Kidwell Virginie , Blocker Christopher , Mas Erick M 
Published: February 2020

Abstract
The authors introduce emotional ability similarity to explain consumer satisfaction in interactions with frontline sales and service employees and other consumers beyond the effects of traditional relational variables in the similarity–attraction paradigm. Four studies examine how and why similar abilities for using emotional information between two people promote relational success in marketplace exchanges. We find that, when interacting with others, consumers who exchange nonverbal information with their partners experience (dis)similarity in their emotional ability (EA). Similar dyads who rely on expressive (high–high EA pairs) or inexpressive (low–low EA pairs) emotion norms experience significantly greater satisfaction in their interactions than consumers with dissimilar norms (high–low EA pairs). Together, these findings advance the understanding of consumer relationships and satisfaction by establishing EA similarity as a new avenue for consumer research.
Long-term outcomes of trans-oral robotic surgery-assisted total laryngectomy for recurrent laryngeal cancers
Authors: Wang Chen-Chi , Lin Wen-Jiun , De Virgilio Armando , Liu Shih-An , Chen Sheng-Hwa , Liao Jia-Shiou 
Published: February 2020

AbstractObjectiveFor recurrent laryngeal cancers, trans-oral robotic surgery has been used to perform total laryngectomy, but limited cases had been reported without long-term outcome follow-up. This study aims at presenting the largest longitudinal retrospective cohort in a single tertiary referral medical center.MethodsFrom November 2013 to August 2017, seven patients with recurrent laryngeal cancers without evidence of neck metastasis were selected to receive trans-oral robotic surgery-assisted TL without neck dissection. The para-operative details including the surgical success rates, surgical methods, resection extent, drainage tube placement, pharyngeal wound closure, console surgical time, pathologic findings and long-term complications were reviewed and described. The study end points include survival rates and preservation of swallowing function without tube feeding.ResultsTrans-oral robotic surgery-assisted total laryngectomy was successfully performed on all seven patients with mean surgical console time of 111 ± 66 min. Strap muscles and hyoid bone were resected like open surgery in six and five patients, respectively. For all the seven patients, there was no severe pharyngo-cutaneous fistula formation requiring repair in a second surgery, but tracheostoma stenosis was not uncommon (57%). Three patients received adjuvant chemotherapy/radiotherapy. After follow-up of 36.1 ± 15.8 months, two patients had neck recurrence, and one patient died 19 months after surgery, but the other five patients were alive without disease recurrence. The overall survival rate was 85.7% (6/7), and all patients had good swallowing function without tube feeding.ConclusionsTrans-oral robotic surgery-assisted total laryngectomy is a feasible approach for selected patients with recurrent laryngeal cancers. The oncologic and functional outcomes were satisfactory. Further larger cohort study is worthwhile to further elucidate the value of trans-oral robotic surgery-assisted total laryngectomy.
Potential Roles of Environmental and Socio-Economic Factors in the Distribution of Insecticide Resistance in Anopheles gambiae sensu lato (Culicidae: Diptera) Across Togo, West Africa
Authors: Ahadji-Dabla Koffi Mensah , Romero-Alvarez Daniel , Djègbè Innocent , Amoudji Adjovi Djifa , Apétogbo Georges Yawo , Djouaka Rousseau , Oboussoumi Komlanvi , Aawi Agnidoufèyi , Atcha-Oubou Tinah , Peterson A Townsend , Ketoh Guillaume Koffivi 
Published: February 2020

Abstract
Vector control strategies recommended by the World Health Organization are threatened by resistance of Anopheles mosquitoes to insecticides. Information on the distribution of resistant genotypes of malaria vectors is increasingly needed to address the problem. Ten years of published and unpublished data on malaria vector susceptibility/resistance and resistance genes have been collected across Togo. Relationships between the spatial distribution of resistance status and environmental, socio-economic, and landscape features were tested using randomization tests, and calculating Spearman rank and Pearson correlation coefficients between mosquito mortality and different gridded values. Anopheles gambiae sensu lato was resistant to DDT, pyrethroids, and the majority of carbamates and organophosphates. Three sibling species were found (i.e., An. gambiae, Anopheles coluzzii, and Anopheles arabiensis) with four resistance genes, including kdr (L1014F, L1014S, and N1575Y) and ace1 (G119S). The most frequent resistance gene was L1014F. Overall, no association was found between the susceptibility/resistance status and environmental features, suggesting that evolution of resistance may be most closely related to extreme selection from local insecticide use. Nevertheless, further research is necessary for firm conclusions about this lack of association, and the potential role of landscape characteristics such as presence of crops and percentage of tree cover.
Do We Need Rights in Bioethics Discourse?
Authors: Sim Julius 
Published: February 2020

AbstractMoral rights feature prominently and are relied on substantially in debates in bioethics. Conceptually, however, duties can perform the logical work of rights, but not vice versa, and reference to rights is therefore inessential. Normatively, rights, like duties, depend on more basic moral values or principles, and attempts to establish the logical priority of rights over duties or the reverse are misguided. In practical decision making, however, an analysis in terms of duties is more fruitful than one based on rights. A right may function as a proxy term for a consequentialist rule, or for a deontological constraint, but does not thereby enrich these concepts. Rights may also help in a purely expressive sense and may assist an initial focusing on a moral conflict. However, their role in bioethics discourse is more one of convenience than of necessity. Moreover, unless rights are firmly founded on fundamental moral values, their use encourages rhetoric rather than argument.
Music Therapy for Preterm Infants and Their Parents: A Cluster-Randomized Controlled Trial Protocol
Authors: Yakobson Dana , Arnon Shmuel , Gold Christian , Elefant Cochavit , Litmanovitz Ita , Beck Bolette Daniels 
Published: February 2020

AbstractMusic therapy (MT) interventions and skin-to-skin care (SSC) both aim to address the varied needs of preterm infants, including sensory regulation and stress reduction, inclusion of parents in their infant’s care, support of parents’ emotional state, and enhancing the parent–infant attachment process. Few studies have investigated the combination of both modalities through randomized controlled trials. Evidence of longer-term effects is missing. This article presents a study protocol that will investigate the effects of combined family-centered MT intervention and SSC on preterm-infants’ autonomic nervous system (ANS) stability, parental anxiety levels, and parent–infant attachment quality. 12 clusters with a total of 72 preterm infants, with their parents, will be randomized to one of two conditions: MT combined with SSC or SSC alone. Each parent–infant dyad will participate in 3 sessions (2 in the hospital and a 3-month follow-up). The primary outcome of preterm infants’ ANS stability will be measured by the high frequency power of their heart rate variability. Secondary outcomes will be physiological measures and behavioral states in infants and anxiety and attachment levels of parents. This trial will provide important, evidence-based knowledge on the use of the “First Sounds: Rhythm, Breath, and Lullaby” model of MT in neonatal care, through an intervention that is in line with the Newborn Individualized Developmental Care and Assessment Program model for supportive developmental care of preterm infants and their parents. Ethical approval (no. 0283-15) was granted from the local Institutional Review Board in April 2017. This trial is registered in ClinicalTrials.gov, NCT03023267.
Pelvic angiomyofibroblastoma: an unusual case report
Authors: Laraqui Housseini Yasmine , Elouazzani Hafsa , Housseini Laila Laraqui , Cherkaoui Meriem , Zouaidia Fouad 
Published: February 2020

Abstract
Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to middle-aged women, arising from the genital tract. There are many overlapping radiological and immunohistochemical features with other stromal cell lesions, making the diagnosis difficult. We report here a case of a 29-year-old woman admitted for a pelvic mass, in whom, the histopathological and immunohistochemical studies led to the diagnosis of angiomyofibroblastoma.
¿Existe correlación entre importancia y centralidad? Evaluación de personajes con redes sociales en obras teatrales de la Edad de Plata
Authors: Santa María María Teresa , Calvo Tello José , Jiménez Concepción María 
Published: February 2020

Abstract
The objective of this study is to answer the question: Do the central nodes of a social network of characters correspond with the protagonists of a theater play? To answer this question we evaluate different measures of centrality along with other textual quantitative values in relation to other manually annotated metadata on a corpus of twenty five dramatic plays of the Spanish theatre of the Silver Age (1868-1936). The found results show that centrality correlates moderately with importance, but the correlation with the textual quantitative values is stronger.
Probing the temperature structure of optically thick discs using polarized emission of aligned grains
Authors: Lin Zhe-Yu Daniel , Li Zhi-Yun , Yang Haifeng , Looney Leslie , Lee Chin-Fei , Stephens Ian , Lai Shih-Ping 
Published: February 2020

ABSTRACT
Polarized continuum emission from aligned grains in discs around young stellar objects can be used to probe the magnetic field, radiation anisotropy, or drift between dust and gas, depending on whether the non-spherical grains are aligned magnetically, radiatively, or mechanically. We show that it can also be used to probe another key disc property – the temperature gradient – along sightlines that are optically thick, independent of the grain alignment mechanism. We first illustrate the technique analytically using a simple 1D slab model, which yields an approximate formula that relates the polarization fraction to the temperature gradient with respect to the optical depth τ at the τ = 1 surface. The formula is then validated using models of stellar irradiated discs with and without accretion heating. The promises and challenges of the technique are illustrated with a number of Class 0 and I discs with ALMA dust polarization data, including NGC 1333 IRAS4A1, IRAS 16293B, BHB 07-11, L1527, HH 212, and HH 111. We find, in particular, that the sightlines passing through the near-side of a highly inclined disc trace different temperature gradient directions than those through the far-side, which can lead to a polarization orientation on the near-side that is orthogonal to that on the far-side, and that the HH 111 disc may be such a case. Our technique for probing the disc temperature gradient through dust polarization can complement other methods, particularly those using molecular lines.
A possible distance bias for type Ia supernovae with different ejecta velocities
Authors: Siebert M R , Foley R J , Jones D O , Davis K W 
Published: February 2020

ABSTRACT
After correcting for their light-curve shape and colour, Type Ia supernovae (SNe Ia) are precise cosmological distance indicators. However, there remains a non-zero intrinsic scatter in the differences between measured distance and that inferred from a cosmological model (i.e. Hubble residuals or HRs), indicating that SN Ia distances can potentially be further improved. We use the open-source relational data base kaepora to generate composite spectra with desired average properties of phase, light-curve shape, and HR. At many phases, the composite spectra from two subsamples with positive and negative average HRs are significantly different. In particular, in all spectra from 9 d before to 15 d after peak brightness, we find that SNe with negative HRs have, on average, higher ejecta velocities (as seen in nearly every optical spectral feature) than SNe with positive HRs. At +4 d relative to B-band maximum, using a sample of 62 SNe Ia, we measure a 0.091 ± 0.035 mag (2.7σ) HR step between SNe with Si ii λ6355 line velocities ($v_{Si\, rm{\small II}}$) higher/lower than −11 000 km s−1 (the median velocity). After light-curve shape and colour correction, SNe with higher velocities tend to have underestimated distance moduli relative to a cosmological model. The intrinsic scatter in our sample reduces from 0.094 to 0.082 mag after making this correction. Using the Si ii λ6355 velocity evolution of 115 SNe Ia, we estimate that a velocity difference &gt;500 km s−1 exists at each epoch between the positive-HR and negative-HR samples with 99.4 per cent confidence. Finally at epochs later than +37 d, we observe that negative-HR composite spectra tend to have weaker spectral features in comparison to positive-HR composite spectra.
The self-similar structure of advection-dominated discs with outflow and radial viscosity
Authors: Ghoreyshi S M , Shadmehri M 
Published: February 2020

ABSTRACT
Observational evidence and theoretical arguments postulate that outflows may play a significant role in the advection-dominated accretion discs (ADAFs). While the azimuthal viscosity is the main focus of most previous studies in this context, recent studies indicated that disc structure can also be affected by the radial viscosity. In this work, we incorporate these physical ingredients and the toroidal component of the magnetic field to explore their roles in the steady-state structure of ADAFs. We thereby present a set of similarity solutions where outflows contribute to the mass loss, angular momentum removal, and the energy extraction. Our solutions indicate that the radial viscosity causes the disc to rotate with a slower rate, whereas the radial gas velocity increases. For strong winds, the infall velocity may be of order the Keplerian speed if the radial viscosity is considered and the saturated conduction parameter is high enough. We show that the strength of magnetic field and of wind can affect the effectiveness of radial viscosity.
Mass transfer of low-mass binaries and chemical anomalies among unevolved stars in globular clusters
Authors: Wei Dandan , Wang Bo , Chen Xuefei , Chen Hailiang , Li Lifang , Jiang Dengkai 
Published: February 2020

ABSTRACT
While it is well known that mass transfer in binaries can pollute the surfaces of the accretors, it is still unclear whether this mechanism can reproduce the observed chemical inhomogeneities in globular clusters. We study the surface abundances of the accretors in low-mass binaries, as a first step towards understanding whether mass transfer in low-mass binaries is one of the potential origins of the aforementioned abundance anomalies in globular clusters. We use the mesa (Modules for Experiments in Stellar Astrophysics) code to calculate binary evolutionary models with different initial donor masses between 0.9 and 1.9 $\rm {M}_\odot$ for an initial metallicity of Z = 0.0034. The results show that in some low-mass binary systems, the accretors exhibit peculiar chemical patterns when they are still unevolved stars, e.g. C and O depletion; Na and N enhancement; and constant Mg, Al, and C+N+O. The abundance patterns of the accretors are significantly different from their initial abundances (or that of normal single stars), and can match the observed populations. These abundance patterns strongly depend not only on the initial parameters of binaries (donor mass, mass ratio, and orbital period), but also on the assumptions regarding mass-transfer efficiency and angular momentum loss. These results support the hypothesis that mass transfer in low-mass binaries is, at least, partly responsible for the unevolved anomalous stars in globular clusters. More work on binary evolutionary models and binary population synthesis is required to fully evaluate the contribution of this scenario.