bluuebunny/crossref_metadata_2025_split huggingface dataset:
And What About the Pharmacist?
Authors: BUIJSEN MARTIN , GÖTTGENS WILMA 
Published: June 2020

AbstractIn the Netherlands, euthanasia has been decriminalized. Termination of life on request and assisted suicide are criminal offences under Dutch law; but if physicians comply with the due care requirements of the Euthanasia Act and report their actions in the manner prescribed by law, they will not be prosecuted. One of the requirements relates to the act of euthanasia itself. If this is to be performed with due medical care, the physician relies on the services of a pharmacist. However, the responsibilities of the pharmacist with respect to euthanasia are not laid down in law. At present, Dutch pharmacists have to make do with professional rules that do not offer adequate solutions for the problems that may arise when euthanasia is performed.
Medical Ethics: Common or Uncommon Morality?
Authors: RHODES ROSAMOND 
Published: June 2020

AbstractThis paper challenges the long-standing and widely accepted view that medical ethics is nothing more than common morality applied to clinical matters. It argues against Tom Beauchamp and James Childress’s four principles; Bernard Gert, K. Danner Clouser and Charles Culver’s ten rules; and Albert Jonsen, Mark Siegler, and William Winslade’s four topics approaches to medical ethics. First, a negative argument shows that common morality does not provide an account of medical ethics and then a positive argument demonstrates why the medical profession requires its own distinctive ethics. The paper also provides a way to distinguish roles and professions and an account of the distinctive duties of medical ethics. It concludes by emphasizing ways in which the uncommon morality approach to medical ethics is markedly different from the common morality approach.
Aristotelian Necessity
Authors: Vogler Candace 
Published: June 2020

AbstractAt the center of contemporary neo-Aristotelian naturalism is the thought that we can account for a great deal of ethics by thinking about what is needful in human life generally. When we think about practices like promising, virtues like justice or courage, and institutions that serve to produce, maintain, and help to reproduce well-ordered social life we can make some headway we consider the sense in which our topic makes some forms of human good possible and even, in some cases, actualizes the very good made possible thereby. G.E.M. Anscombe introduced this kind of thinking about ethics, which Philippa Foot named ‘Aristotelian Necessity'. In this essay, I take a hard Look at Anscombe’s work on the topic, and then consider her later insistence that crucial aspects of ethics could not be understood in these terms.
Virtues as Perfections of Human Powers: On the Metaphysics of Goodness in Aristotelian Naturalism
Authors: Hacker-Wright John 
Published: June 2020

AbstractThe central idea of Philippa Foot’s Natural Goodness is that moral judgments belong to the same logical kind of judgments as those that attribute natural goodness and defect to plants and animals. But moral judgments focus on a subset of human powers that play a special role in our lives as rational animals, namely, reason, will, and desire. These powers play a central role in properly human actions: those actions in which we go for something that we see and understand as good. Many readers of Foot resolutely ignore what she says about the human good being sui generis and obstinately continue to read her as advocating a version of naturalism grounded in empirical study of human nature. One might wonder how else it could count as a naturalistic view unless we could square the view with nature as studied by the empirical sciences. In this paper, I propose a metaphysical response to this question: help can come from turning to recent defenses of Aristotelian essentialism. Foot’s naturalism can square with nature as interpreted through the lens of Aristotelian essentialism. On such a view, the virtues are perfections of human powers including reason, will, and desire.
A Philosopher of singular style and multiple modes
Authors: Haldane John 
Published: June 2020

AbstractElizabeth Anscombe was one of the most gifted and productive philosophers of the decades following the Second World War. Her writings present challenges to readers: some of them are very difficult to comprehend while others seem philosophically-minded yet situated outside of philosophy as such. There are also the issues of whether she had a philosophical method and of the influence of Wittgenstein on the manner of her approach. A summary and estimate of Anscombe’s enduring contributions is presented before exploring the style and aims of her philosophical work. Then two of her writings on religion are examined and their implications for her attitude to philosophy considered.
Alternative dispute resolution and access to justice in Australia
Authors: Noone Mary Anne , Ojelabi Lola Akin 
Published: June 2020

AbstractIn the last four decades, there has been a significant increase in the number and variety of appropriate dispute-resolution (ADR) institutions and processes in Australia as a critical aspect of improved access to justice. Although more people can get assistance to resolve their disputes, the issues of whether this access is shared equally within the community, how the disadvantaged fare in these processes and what type of justice is provided by the various ADR processes are explored. The relevance of legislative objectives of ADR fora and processes to justice outcomes is highlighted. It is argued that ADR processes need to be designed and implemented bearing in mind the type/nature of the dispute, parties involved and availability of resources, and to have an overarching objective of promoting access to justice for users. Additionally, improved access to justice requires ongoing and rigorous evaluation of ADR processes to ascertain whether justice objectives are being achieved.
Nick Martin’s Contributions to Human Sexuality Research
Authors: Verweij Karin J. H. , Zietsch Brendan P. 
Published: June 2020

AbstractGenetic research into human sexuality was scarce at the end of last century. In 1992 Nick developed a 12-page questionnaire to send to twins to investigate the underpinnings of sexuality. The questionnaire included items about sexual orientation, sociosexuality and sexual behavior, and was completed by almost 5000 twins. The resulting data, unique at the time, has been used to investigate many previously unexaminable research questions. Here we describe how Nick’s questionnaire contributed to our understanding of human sexuality and how we got involved in this endeavor.
Want to Work on Asthma Genetics?
Authors: Ferreira Manuel A. R. 
Published: June 2020

AbstractTwins, data and emails. Some of the words that first come to mind when I think of Nick. Lots of twins. With lots of data. And short single-finger-typed emails. And great wine. Well, it works, there is no doubt. That’s how I ended up in Australia, working on asthma genetics.
Zonal Similarity of Long‐Term Changes and Seasonal Cycles of Baseline Ozone at Northern Midlatitudes
Authors: Parrish David D. , Derwent Richard G. , Steinbrecht Wolfgang , Stübi René , Van Malderen Roeland , Steinbacher Martin , Trickl Thomas , Ries Ludwig , Xu Xiaobin 
Published: June 2020

AbstractThe lifetime of ozone in the troposphere is approximately 3 weeks. Prevailing westerly winds at northern midlatitudes can transport air around the globe in that time. Hence, within these latitudes zonal similarity is expected in long‐term changes and seasonal cycles of concentrations of baseline ozone. We quantify the degree of zonal similarity by examining eight in situ baseline ozone data sets near the west coasts of North America and Europe, that is, upwind of those continents and downwind of the Pacific and Atlantic Oceans, where the impacts of local and regional ozone sources have been largely mixed into the troposphere, giving the best‐defined baseline ozone signature. Zonal similarity is found in both long‐term changes and seasonal cycles. The decades‐long increase in Northern Hemisphere, midlatitude baseline mixing ratios (average ~0.60 ppb year−1 from 1980–2000), has ended, with a maximum reached in the mid‐2000s, followed by slow decrease (average = −0.09 ± 0.08 ppb year−1 from 2000 to the present). The year of the ozone maximum exhibits little if any statistically significant difference with location, altitude, or season. The ozone seasonal cycle differs markedly between sea‐level coastal stations representative of the marine boundary layer and the free troposphere sampled at elevated sites and by sondes and aircraft. However, within each of these broad tropospheric layers, the seasonal cycles are similar at all locations. Vertical profiles of the parameters that define the long‐term trends and the seasonal cycle are also similar between North America and Europe.
Numerical Modeling of Fracture Network Evolution in Organic‐Rich Shale With Rapid Internal Fluid Generation
Authors: Rabbel Ole , Mair Karen , Galland Olivier , Grühser Carina , Meier Tobias 
Published: June 2020

AbstractWhen low‐permeability and organic‐rich rocks such as shale experience sufficient heating, chemical reactions including shale dehydration and maturation of organic matter lead to internal fluid generation. This may cause substantial pore fluid overpressure and fracturing. In the vicinity of igneous intrusions emplaced in organic‐rich shales, temperatures of several hundred degrees accelerate these processes and lead to intense fracturing. The resulting fracture network provides hydraulic pathways, which allow fluid expulsion and affect hydrothermal fluid flow patterns. However, the evolution of these complex fracture networks and controls on geometry and connectivity are poorly understood. Here, we perform a numerical modeling study based on the extended finite element method to investigate coupled hydromechanical fracture network evolution due to fast internal fluid generation. We quantify the evolution of different initial fracture networks under varying external stresses by analyzing parameters including fracture length, opening, connectivity, and propagation angles. The results indicate a three‐phase process including (1) individual growth, (2) interaction, and (3) expulsion phase. Magnitude of external stress anisotropy and degree of fracture alignment with the largest principal stress correlate with increased fracture opening. We additionally find that although the external stress field controls the overall fracture orientation distribution, local stress interactions may cause significant deviations of fracture paths and control the coalescence characteristics of fractures. Establishing high connectivity in cases with horizontally aligned initial fractures requires stress anisotropy with σV > σH, while the initial orientation distribution is critical for connectivity if stresses are nearly isotropic.
Increased Dust Aerosols in the High Troposphere Over the Tibetan Plateau From 1990s to 2000s
Authors: Feng Xingya , Mao Rui , Gong Dao‐Yi , Zhao Chun , Wu Chenglai , Zhao Chuanfeng , Wu Guangjian , Lin Zhaohui , Liu Xiaohong , Wang Kaicun , Sun Yijie 
Published: June 2020

AbstractDust aerosols are a major type of aerosol over the Tibetan Plateau (TP) and influence climate at local to regional scales through their effects on thermal radiation and snow‐albedo feedback. Based on the Modern‐Era Retrospective Analysis for Research and Applications, Version 2 (MERRA‐2) aerosol data set, we report an increase of 34% in the atmospheric dust in the high troposphere over the TP during the spring season in the 2000s in comparison to the 1990s. This result is supported by an increase of 157% (46%) in the dust deposition flux in the Mugagangqiong (Tanggula) ice cores and an increase of 69% in the aerosol index (AI) from Earth Probe (EP) Total Ozone Mapping Spectrometer (TOMS), as well as by increases of simulated dust aerosols over the TP derived from the Community Earth System Model (CESM) and models from the Coupled Model Intercomparison Project Phase 6 (CMIP6). The increased atmospheric dust over the TP is caused by two aspects: (1) There was a higher dust emission over the Middle East during the 2000s than during the 1990s, which is explained by less precipitation and 25.8% higher cyclone frequency over the Middle East. The increased cyclone frequency uplift more dust from the surface over the Middle East to the central Asia in the middle troposphere. (2) Enhanced midlatitude zonal winds help transport more dust in the middle troposphere from central Asia to Northwest China, and thereafter, an increase in northerly winds over Northwest China propels dust southward to the TP.
The CNRM Global Atmosphere Model ARPEGE‐Climat 6.3: Description and Evaluation
Authors: Roehrig Romain , Beau Isabelle , Saint‐Martin David , Alias Antoinette , Decharme Bertrand , Guérémy Jean‐François , Voldoire Aurore , Abdel‐Lathif Ahmat Younous , Bazile Eric , Belamari Sophie , Blein Sebastien , Bouniol Dominique , Bouteloup Yves , Cattiaux Julien , Chauvin Fabrice , Chevallier Matthieu , Colin Jeanne , Douville Hervé , Marquet Pascal , Michou Martine , Nabat Pierre , Oudar Thomas , Peyrillé Philippe , Piriou Jean‐Marcel , Salas y Mélia David , Séférian Roland , Sénési Stéphane 
Published: June 2020

AbstractThe present study describes the atmospheric component of the sixth‐generation climate models of the Centre National de Recherches Météorologiques (CNRM), namely, ARPEGE‐Climat 6.3. It builds up on more than a decade of model development and tuning efforts, which led to major updates of its moist physics. The vertical resolution has also been significantly increased, both in the boundary layer and in the stratosphere. ARPEGE‐Climat 6.3 is now coupled to the new version (8.0) of the SURFace EXternalisée (SURFEX) surface model, in which several new features (e.g., floodplains, aquifers, and snow processes) improve the water cycle realism. The model calibration is discussed in depth. An amip‐type experiment, in which the sea surface temperatures and sea ice concentrations are prescribed, and following the CMIP6 protocol, is extensively evaluated, in terms of climate mean state and variability. ARPEGE‐Climat 6.3 is shown to improve over its previous version (5.1) by many climate features. Major improvements include the top‐of‐atmosphere and surface energy budgets in their various components (shortwave and longwave, total and clear sky), cloud cover, near‐surface temperature, precipitation climatology and daily‐mean distribution, and water discharges at the outlet of major rivers. In contrast, clouds over subtropical stratocumulus decks, several dynamical variables (sea level pressure, 500‐hPa geopotential height), are still significantly biased. The tropical intraseasonal variability and diurnal cycle of precipitation, though improved, remained area of concerns for further model improvement. New biases also emerge, such as a lack of precipitation over several tropical continental areas. Within the CMIP6 context, ARPEGE‐Climat 6.3 is the atmospheric component of CNRM‐CM6‐1 and CNRM‐ESM2‐1.
Genetic architecture of Environmental Sensitivity reflects multiple heritable components: a twin study with adolescents
Authors: Assary Elham , Zavos Helena M. S. , Krapohl Eva , Keers Robert , Pluess Michael 
Published: June 2020

AbstractHumans differ substantially in how strongly they respond to similar experiences. Theory suggests that such individual differences in susceptibility to environmental influences have a genetic basis. The present study investigated the genetic architecture of Environmental Sensitivity (ES) by estimating its heritability, exploring the presence of multiple heritable components and its genetic overlap with common personality traits. ES was measured with the Highly Sensitive Child (HSC) questionnaire and heritability estimates were obtained using classic twin design methodology in a sample of 2868 adolescent twins. Results indicate that the heritability of sensitivity was 0.47, and that the genetic influences underlying sensitivity to negative experiences are relatively distinct from sensitivity to more positive aspects of the environment, supporting a multi-dimensional genetic model of ES. The correlation between sensitivity, neuroticism and extraversion was largely explained by shared genetic influences, with differences between these traits mainly attributed to unique environmental influences operating on each trait.
CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus
Authors: Pei Yujun , Wen Kun , Xiang Zheng , Huang Chunyu , Wang Xiwei , Mu Xiaofeng , Wen Liyan , Liu Yinping , Tu Wenwei 
Published: June 2020

AbstractInfluenza epidemics and pandemics are constant threats to global public health. Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection, the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains. Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections. However, one notable drawback of γδ-T cell-based immunotherapy is the rapid exhaustion of proliferation and effector responses due to repeated treatments with phosphoantigens. Here, we found that the expression of CD137 was inducible in Vγ9Vδ2-T cells following antigenic stimulation. CD137+ Vγ9Vδ2-T cells displayed more potent antiviral activity against influenza virus than their CD137− counterparts in vitro and in Rag2-/- γc-/- mice. We further demonstrated that CD137 costimulation was essential for Vγ9Vδ2-T cell activation, proliferation, survival and effector functions. In humanized mice reconstituted with human peripheral blood mononuclear cells, CD137 costimulation with a recombinant human CD137L protein boosted the therapeutic effects of pamidronate against influenza virus. Our study provides a novel strategy of targeting CD137 to improve the efficacy of Vγ9Vδ2-T cell-based immunotherapy.
A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study
Authors: Collignon A. , Hospital M. A. , Montersino C. , Courtier F. , Charbonnier A. , Saillard C. , D’Incan E. , Mohty B. , Guille A. , Adelaïde J. , Carbuccia N. , Garnier S. , Mozziconacci M. J. , Zemmour C. , Pakradouni J. , Restouin A. , Castellano R. , Chaffanet M. , Birnbaum D. , Collette Y. , Vey N. 
Published: June 2020

AbstractTargeted next-generation sequencing (tNGS) and ex vivo drug sensitivity/resistance profiling (DSRP) have laid foundations defining the functional genomic landscape of acute myeloid leukemia (AML) and premises of personalized medicine to guide treatment options for patients with aggressive and/or chemorefractory hematological malignancies. Here, we have assessed the feasibility of a tailored treatment strategy (TTS) guided by systematic parallel ex vivo DSRP and tNGS for patients with relapsed/refractory AML (number NCT02619071). A TTS issued by an institutional personalized committee could be achieved for 47/55 included patients (85%), 5 based on tNGS only, 6 on DSRP only, while 36 could be proposed on the basis of both, yielding more options and a better rationale. The TSS was available in <21 days for 28 patients (58.3%). On average, 3 to 4 potentially active drugs were selected per patient with only five patient samples being resistant to the entire drug panel. Seventeen patients received a TTS-guided treatment, resulting in four complete remissions, one partial remission, and five decreased peripheral blast counts. Our results show that chemogenomic combining tNGS with DSRP to determine a TTS is a promising approach to propose patient-specific treatment options within 21 days.
Fires prime terrestrial organic carbon for riverine export to the global oceans
Authors: Jones Matthew W. , Coppola Alysha I. , Santín Cristina , Dittmar Thorsten , Jaffé Rudolf , Doerr Stefan H. , Quine Timothy A. 
Published: June 2020

AbstractBlack carbon (BC) is a recalcitrant form of organic carbon (OC) produced by landscape fires. BC is an important component of the global carbon cycle because, compared to unburned biogenic OC, it is selectively conserved in terrestrial and oceanic pools. Here we show that the dissolved BC (DBC) content of dissolved OC (DOC) is twice greater in major (sub)tropical and high-latitude rivers than in major temperate rivers, with further significant differences between biomes. We estimate that rivers export 18 ± 4 Tg DBC year−1 globally and that, including particulate BC fluxes, total riverine export amounts to 43 ± 15 Tg BC year−1 (12 ± 5% of the OC flux). While rivers export ~1% of the OC sequestered by terrestrial vegetation, our estimates suggest that 34 ± 26% of the BC produced by landscape fires has an oceanic fate. Biogeochemical models require modification to account for the unique dynamics of BC and to predict the response of recalcitrant OC export to changing environmental conditions.
A big data approach to improving the vehicle emission inventory in China
Authors: Deng Fanyuan , Lv Zhaofeng , Qi Lijuan , Wang Xiaotong , Shi Mengshuang , Liu Huan 
Published: June 2020

AbstractEstimating truck emissions accurately would benefit atmospheric research and public health protection. Here, we developed a full-sample enumeration approach TrackATruck to bridge low-frequency but full-size vehicles driving big data to high-resolution emission inventories. Based on 19 billion trajectories, we show how big the emission difference could be using different approaches: 99% variation coefficients on regional total (including 31% emissions from non-local trucks), and ± as large as 15 times on individual counties. Even if total amounts are set the same, the emissions on primary cargo routes were underestimated in the former by a multiple of 2–10 using aggregated approaches. Time allocation proxies are generated, indicating the importance of day-to-day estimation because the variation reached 26-fold. Low emission zone policy reduced emissions in the zone, but raised emissions in upwind areas in Beijing's case. Comprehensive measures should be considered, e.g. the demand-side optimization.
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
Authors: Loh Nellie Y. , Minchin James E. N. , Pinnick Katherine E. , Verma Manu , Todorčević Marijana , Denton Nathan , Moustafa Julia El-Sayed , Kemp John P. , Gregson Celia L. , Evans David M. , Neville Matt J. , Small Kerrin S. , McCarthy Mark I. , Mahajan Anubha , Rawls John F. , Karpe Fredrik , Christodoulides Constantinos 
Published: June 2020

AbstractFat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase RSPO3 expression in subcutaneous adipocytes. These variants are also associated with reduced lower-body fat, enlarged gluteal adipocytes and insulin resistance. Based on human cellular studies RSPO3 may limit gluteofemoral adipose tissue (AT) expansion by suppressing adipogenesis and increasing gluteal adipocyte susceptibility to apoptosis. RSPO3 may also promote upper-body fat distribution by stimulating abdominal adipose progenitor (AP) proliferation. The distinct biological responses elicited by RSPO3 in abdominal versus gluteal APs in vitro are associated with differential changes in WNT signalling. Zebrafish carrying a nonsense rspo3 mutation display altered fat distribution. Our study identifies RSPO3 as an important determinant of peripheral AT storage capacity.