bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing Expertise and Collaboration to Support Students With Brain Injury: A Case Study in Speech-Language Pathology
Authors: Salley Jessica , Krusen Sarah , Lockovich Margaret , Wilson Bethany , Eagan-Johnson Brenda , Tyler Janet 
Published: November 2019

Purpose
Through a hypothetical case study, this article aimed to describe an evidence-based approach for speech-language pathologists in managing students with moderate-to-severe traumatic brain injury (TBI), particularly within a formal statewide-supported school-based brain injury team model, such as the BrainSTEPS Brain Injury School Consulting Program operating in Pennsylvania and Colorado.

Conclusion

Upon transitioning from the medical setting back to school, children with TBI present with unique educational needs. Children with moderate-to-severe TBIs can demonstrate a range of strengths and deficits in speech, language, cognition, and feeding and swallowing, impacting their participation in various school activities. The specialized education, training, and insight of speech-language pathologists, in collaboration with multidisciplinary medical and educational team members, can enable the success of students with TBI when transitioning back to school postinjury (
DePompei & Blosser, 2019
;
DePompei & Tyler, 2018
). This transition should focus on educational planning, implementation of strategies and supports, and postsecondary planning for vocations or higher education.
Transgender and Nonbinary Adolescents: The Role of Voice and Communication Therapy
Authors: Russell Meredith R. , Abrams Mere 
Published: November 2019

Purpose
Current literature to describe the role of voice and communication therapy in gender-affirming interdisciplinary care for transgender and nonbinary adolescents is very limited. As a result, professionals providing voice and communication therapy are not always integrated into gender clinics and treatment plans for patients seeking gender-affirming care. Using case studies to demonstrate the complexity and nuance of gender-affirming care, this clinical focus article provides education about gender identity, gender expression, and gender roles as well as rationale and outcomes for voice and communication therapy with transgender and nonbinary adolescents.

Conclusion
An interdisciplinary and gender-affirming approach is critical for adolescent voice and speech therapy success. Given the state of transgender health care and need for evidence-based interventions, this clinical focus article addresses gaps in training and research by recommending an interdisciplinary and culturally responsive approach to voice and communication therapy with transgender and nonbinary adolescents.
Idealised simulations of the deep atmosphere of hot Jupiters
Authors: Sainsbury-Martinez F. , Wang P. , Fromang S. , Tremblin P. , Dubos T. , Meurdesoif Y. , Spiga A. , Leconte J. , Baraffe I. , Chabrier G. , Mayne N. , Drummond B. , Debras F. 
Published: November 2019

Context. The anomalously large radii of hot Jupiters has long been a mystery. However, by combining both theoretical arguments and 2D models, a recent study has suggested that the vertical advection of potential temperature leads to a hotter adiabatic temperature profile in the deep atmosphere than the profile obtained with standard 1D models.
Aims. In order to confirm the viability of that scenario, we extend this investigation to 3D, time-dependent models.
Methods. We use a 3D general circulation model DYNAMICO to perform a series of calculations designed to explore the formation and structure of the driving atmospheric circulations, and detail how it responds to changes in both the upper and deep atmospheric forcing.
Results. In agreement with the previous, 2D study, we find that a hot adiabat is the natural outcome of the long-term evolution of the deep atmosphere. Integration times of the order of 1500 yr are needed for that adiabat to emerge from an isothermal atmosphere, explaining why it has not been found in previous hot Jupiter studies. Models initialised from a hotter deep atmosphere tend to evolve faster toward the same final state. We also find that the deep adiabat is stable against low-levels of deep heating and cooling, as long as the Newtonian cooling timescale is longer than ~3000 yr at 200 bar.
Conclusions. We conclude that steady-state vertical advection of potential temperature by deep atmospheric circulations constitutes a robust mechanism to explain the inflated radii of hot Jupiters. We suggest that future models of hot Jupiters be evolved for a longer time than currently done, and when possible that models initialised with a hot deep adiabat be included. We stress that this mechanism stems from the advection of entropy by irradiation-induced mass flows and does not require a (finely tuned) dissipative process, in contrast with most previously suggested scenarios.
The origin of the high metallicity of close-in giant exoplanets
Authors: Shibata Sho , Helled Ravit , Ikoma Masahiro 
Published: November 2019

Context. Recent studies suggest that in comparison to their host star, many giant exoplanets are highly enriched with heavy elements and can contain several tens of Earth masses of heavy elements or more. Such enrichment is considered to have been delivered by the accretion of planetesimals in late formation stages. Previous dynamical simulations, however, have shown that planets cannot accrete such high masses of heavy elements through “in situ” planetesimal accretion.
Aims. We investigate whether a giant planet migrating inward can capture planetesimals efficiently enough to significantly increase its metallicity.
Methods. We performed orbital integrations of a migrating giant planet and planetesimals in a protoplanetary gas disc to infer the planetesimal mass that is accreted by the planet.
Results. We find that the two shepherding processes of mean motion resonance trapping and aerodynamic gas drag inhibit the planetesimal capture of a migrating planet. However, the amplified libration allows the highly-excited planetesimals in the resonances to escape from the resonance trap and to be accreted by the planet. Consequently, we show that a migrating giant planet captures planetesimals with total mass of several tens of Earth masses if the planet forms at a few tens of AU in a relatively massive disc. We also find that planetesimal capture occurs efficiently in a limited range of semi-major axis and that the total captured planetesimal mass increases with increasing migration distances. Our results have important implications for understanding the relation between giant planet metallicity and mass, as we suggest that it reflects the formation location of the planet – or more precisely, the location where runaway gas accretion occurred. We also suggest the observed metal-rich close-in Jupiters migrated to their present locations from afar, where they had initially formed.
Swinging-Flashlight-Test – Schritt für Schritt
Authors: Demberg Lilian , Ehrt Oliver 
Published: November 2019

ZusammenfassungDie Abklärung unklarer Sehstörungen ist ein schwieriger Prozess. Dem Swinging-Flashlight-Test kommt aufgrund fehlender Invasivität, schneller Durchführbarkeit und seinem großen differenzialdiagnostischen Wert eine Schlüsselrolle bei der Abklärung unklarer Sehstörungen zu – vorausgesetzt er wird korrekt durchgeführt.
Möglichkeiten der vaskularisierten Knochentransplantationen bei Defektpseudarthrosen an ausgewählten Beispielen der oberen Extremität
Authors: Evers Saskia Carolin , Daigeler Adrien , Wahler Theodora 
Published: November 2019

ZusammenfassungEine über 6 Monate nach Trauma bestehende ausbleibende Knochenbruchheilung wird in der Literatur als Pseudarthrose definiert. Die Inzidenz liegt zwischen 1 und 5%, abhängig von der Frakturlokalisation 1. In der Frühphase kann bei ausreichender Stabilität der Fraktur ein konservativer Therapieversuch unternommen werden. Die operative Therapie sollte anhand der Pathophysiologie und Morphologie der Pseudarthrose gewählt werden. Steht eine Minderdurchblutung der Frakturzone im Vordergrund kann die Durchblutungssituation zunächst durch das Anfrischen der Frakturenden, durch eine Spongiosaplastik, aber bspw. auch durch die Verwendung eines vaskularisierten Knochenspans verbessert werden 2. Die freie gestielte Fibulatransplantation spielt bei einer langstreckigen Defektpseudarthrose des Unterarmes die Methode der Wahl dar. Der kortikoperiostale Lappen der medialen Femurkondyle bietet mit seinen osteogenen Potenzen eine gute Alternative bei kleinen Defekten oder anatomisch anspruchsvollen Empfängerregionen. Bei kleinen knöchernen oder ausgeprägten Weichteildefekten finden der vaskularisierte Beckenkammspan sowie die Transplantation der medialen oder lateralen Skapula Verwendung. Bei einer persistierenden Kahnbeinpseudarthrose bieten sich als vaskularisierte Rekonstruktionsmöglichkeiten sowohl der gefäßgestielte dorsale oder palmare Radiusspan als auch der freie kortikospongiöse mediale Femurspan an.
Lipoma arborescens – Uncommon Diagnosis for Joint Swelling: Case Report and Review of the Literature
Authors: Theermann Ralf , Ohlmeier Malte , Hartwig Carl Heinz , Wolff Matthias , Krenn Veit , Liewen Caroline , Citak Mustafa , Gehrke Thorsten 
Published: November 2019

Abstract
Introduction Soft tissue swelling of the knee joint can be caused by many diseases. Lipomas are one of the most reasonable differential diagnoses we have to consider. Therefore, we now present the uncommon case of a Lipoma arborescens (LA) and differentiate it from a quite similar manifesting spindle cell lipoma as follows.
Case Report A 49-years old patient reports about progressive knee pain for four years and observes an increasing joint swelling. This swelling is a soft tissue, shiftable tumour, not painful. The magnetic resonance imaging (MRI) with contrast agent brings the diagnosis of an advanced osteoarthritis of the knee joint and classifies the tumour as LA. Subsequently, we treat the osteoarthritis by implanting a total knee arthroplasty with simultaneous intraoperative tumour resection performed as total synovectomy. The histopathological processing confirms the clinically and radiologically made diagnosis of LA.
Summary Lipoma arborescens presents an uncommon subgroup of Lipomas, which is characterized by a slowly progressive increasing soft tissue swelling, especially around bigger human joints. Due to its intraarticular location, the LA might become clinically relevant when it reaches a certain tumour size. Looking at the diagnostics, sonography, MRI and especially the histopathological processing give the crucial results. Final proof can only be made by histopathological examination. Additionally, we have some differential diagnoses to exclude. Under these we predominantly find the spindle cell lipoma, synovial haemagioma, vascular synovial malformations and tenosynovial giant-cell tumour. Furthermore, an atypical lipomatous tumour should be excluded by FISH-analysis via determining the MDM2-Genamplification.
Retrospektive GKV-Versorgungsforschungsstudie über GnRH-Antagonisten/-Agonisten zur initialen Therapie des fortgeschrittenen Prostatakarzinoms – Verordnungsmuster und Krankenhauskosten in Deutschland
Authors: Hupe Marie Christine , Hammerer Peter , Ketz Miriam , Kossack Nils , Colling Christiane , Merseburger Axel S. 
Published: November 2019

Zusammenfassung
Hintergrund Die Androgendeprivationstherapie (ADT) ist fester Therapiebestandteil des fortgeschrittenen oder metastasierten Prostatakarzinoms (PCa). Ziel der vorliegenden Versorgungsforschungsstudie war der Vergleich von Verordnungsmustern, Hospitalisierungsraten und Krankenhauskosten beim initialen Einsatz verschiedener GnRH-Agonisten und -Antagonisten (GnRHa).
Material und Methoden Anonymisierte GKV-Daten von > 70 Krankenkassen aus 2010 bis 2015 (n = 4 205 227) wurden analysiert (1 Jahr Vorbeobachtung, 1 Indexquartal mit initialer GnRHa-Verordnung, ≥ 2 Jahre Follow-Up (FU)).
Ergebnisse Die Studienpopulation umfasste 2382 PCa-Patienten im Alter von durchschnittlich 75 Jahren. Leuprorelin (Leu) wurde mit 56,6 % am häufigsten verordnet. Bei erstmaliger GnRHa-Anwendung hatten 70 % aller Patienten keine Lymph- oder Fernmetastasen. Nach der initialen Verordnung wurden bei 11,2 % die GnRHa abgesetzt, bei 17,6 % nach durchschnittlich 457 Tagen (Median: 399 Tage) umgestellt, in der Hybrid (Hyb)-Gruppe durchschnittlich 100 Tage schneller als bei den Agonisten (p = 0,016). Die Prävalenzrangfolge der häufigsten Komorbiditäten war über die Zeit gleichbleibend: Hypertonie, Hyperlipidämie, kardiovaskuläre Erkrankungen (CVD) und Diabetes. Die Hypertonieprävalenz zeigte einen signifikant höheren Anstieg unter Agonisten (16,4 %; vs. Antagonist 6,9 % p = 0,022; vs. Hybride 11,6 % p = 0,006). Bei der CVD gab es hinsichtlich der relativen Wachstumsraten zwischen den 3 zusammengefassten Therapieklassen keine signifikanten Unterschiede. Insgesamt waren 23,9 % aller Patienten nach 3 Jahren FU verstorben. Die Mortalitätsrate war am niedrigsten für Triptorelin (Trp, 22,1 %) und am höchsten für Goserelin (Gos, 29,4 %, n.s.). Im Indexquartal hatten 26,4 % der Patienten mind. einen Krankenhausaufenthalt [min; max: Trp 22,4 %; Gos 30,3 %] mit einer mittleren Krankenhausverweildauer/Patient von 3 Tagen [Trp 2,4; Gos 4,5]. Die jährliche Hospitalisierungsrate lag bei 36,2 – 40,7 %, die mittlere Krankenhausverweildauer im gesamten FU zwischen 17,6 (Trp) und 20,8 (Hyb) Tagen. Die Krankenhauskosten im Indexquartal betrugen ca. 1200 EUR [Trp 988; Gos 1803] und pro FU-Jahr ca. 3000 EUR. In der Trp-Kohorte lagen die Gesamtkosten (Indexquartal + 3 Jahre) mehr als 1000 EUR unter dem Durchschnitt von 9476 EUR [Trp 8116; Leu 9779; n.s.].
Schlussfolgerung Diese GKV-Versorgungsforschungsstudie beschreibt die Anwendung von GnRHa zur initialen Therapie beim fortgeschrittenen PCa in Deutschland und zeigt substanzabhängige Unterschiede in den Verordnungsmustern, Hospitalisierungsraten und Krankenhauskosten.
Referenzwerte für die kardiorespiratorische Fitness der allgemeinen Bevölkerung: Die Studie zur Gesundheit Erwachsener in Deutschland (DEGS1) 2008–2011
Authors: Finger Jonas David , Banzer WinfriedE. , Baumeister Sebastian Edgar , Brandes Mirko , Bös Klaus , Gabrys Lars , Gößwald Antje , Härtel Sascha , Kluttig Alexander , Kuhnert Ronny , Leitzmann MichaelF. , Löllgen Herbert H. , Manz Kristin , Mensink GertB.M. , Niessner Claudia , Rosario Angelika Schaffrath , Kurth Bärbel-Maria 
Published: November 2019

ZusammenfassungZiel der Studie Das Ziel dieser Auswertung ist die Erstellung bundesweiter, bevölkerungsbezogener Referenzwerte für herzfrequenzbasierte Indikatoren der kardiorespiratorischen Fitness sporttauglicher Erwachsener im Alter von 18 bis 64 Jahren.Methodik Auf der Datenbasis von 2826 Teilnehmenden des submaximalen Fahrradergometer-Tests in der „Studie zur Gesundheit Erwachsener in Deutschland“ (DEGS1) 2008–2011 wurden folgende körpergewichtsbezogene Indikatoren gebildet: Physical Working Capacity (herzfrequenzbezogene Leistung) bei 150 und 130 S/min, bei 75% der geschätzten maximalen Herzfrequenz (PWC130, PWC150 und PWC75%) sowie die herzfrequenzbasiert geschätzte maximale Sauerstoffaufnahme (VO2max). Die Referenzwerteberechnung erfolgte mit der LMS-Methode nach Cole & Green 1992.Ergebnisse Das 25., 50. und 75. Perzentil der PWC150 liegt bei Männer bei 1,50, 1,77 und 2,08 Watt/kg. Die entsprechenden Werte bei Frauen sind 1,18, 1,44 und 1,69. Das 25., 50. und 75. Perzentil der PWC130 liegt bei Männer bei 1,16, 1,41 und 1,68 Watt/kg. Die entsprechenden Werte bei Frauen sind 0,81, 1,05 und 1,29. Die altersabhängigen Mediane bei Männern und Frauen sind für die PWC75% 1,87 – Alter in Jahren× 0,01 und 1,31 – (Alter in Jahren/100)2 x 0,98 und für die VO2max bei Männern 41,7 – Alter× 0,15.Schlussfolgerung Die präsentierten Ergebnisse können als Referenzwerte für die Einschätzung der individuellen kardiorespiratorischen Fitness von in Deutschland lebenden Erwachsenen eingesetzt werden. Sie können außerdem als Basis für ein regelmäßiges Monitoring dienen.
Convenient One-Pot Synthesis of Allylsilanes from Enolizable Ketones
Authors: Kwan Man Lung D. , Challen Paul R. , Tran Quynh D.-D. 
Published: November 2019

A convenient one-pot synthesis of allylsilanes from enolizable methyl aryl ketones has been developed. The first step involves nucleophilic addition of the trimethylsilylmethyl group to ketones using the alkylation method developed by Ishihara with slight modification to generate the corresponding β-silylalkoxides. The second step entails addition of diisobutylaluminum chloride and heating at about 130 °C overnight to afford allylsilanes in fair yields.
Synthesis of Biphenylenes and Their π-Extended Derivatives
Authors: Pan Ming-Lun , Wu Yao-Ting 
Published: November 2019

A series of biphenylenes and their π-extended derivatives are easily prepared through tert-butyllithium-mediated cyclization of suitable halobiaryls and haloteraryls, respectively. The reactions proceed via the corresponding arynyl intermediates at low temperature (up to –20 °C).
Lewis Base Catalysis Based on Homoconjugate Addition: Rearrangement of Electron-Deficient Cyclopropanes and Their Derivatives
Authors: Babu Kaki Raveendra , He Xin , Xu Silong 
Published: November 2019

Cyclopropane is one of the most reactive functionalities owing to its intrinsic ring strain. Transition-metal catalysis and Lewis acid catalysis have been extensively used in ring openings of cyclopropanes; however, Lewis base-catalyzed activation of cyclopropanes remains largely unexplored. Upon nucleophilic attack with Lewis bases, cyclopropanes undergo ring cleavage in a manner known as homoconjugate addition to form zwitterionic intermediates, which have significant potential for reaction development but have garnered little attention. Here, we present a brief overview of this area, with an emphasis on our recent efforts on Lewis base-catalyzed rearrangement reactions of electron-deficient cyclopropanes using the homoconjugate addition process.1	Introduction2	DABCO-Catalyzed Cloke–Wilson Rearrangement of Cyclopropyl Ketones3	Hydroxylamine-Mediated Tandem Cloke–Wilson/Boulton–­Katritzky Reaction of Cyclopropyl Ketones4	Phosphine-Catalyzed Rearrangement of Vinylcyclopropyl Ketones To Form Cycloheptenones5	Phosphine-Catalyzed Rearrangement of Alkylidenecyclopropyl Ketones To Form Polysubstituted Furans and Dienones6	Conclusion and Outlook
Overrating Classifier Performance in ROC Analysis in the Absence of a Test Set: Evidence from Simulation and Italian CARATkids Validation
Authors: Cilluffo Giovanna , Fasola Salvatore , Ferrante Giuliana , Montalbano Laura , Baiardini Ilaria , Indinnimeo Luciana , Viegi Giovanni , Fonseca Joao A. , La Grutta Stefania 
Published: November 2019

Background The use of receiver operating characteristic curves, or “ROC analysis,” has become quite common in biomedical research to support decisions. However, sensitivity, specificity, and misclassification rates are still often estimated using the training sample, overlooking the risk of overrating the test performance.
Methods A simulation study was performed to highlight the inferential implications of splitting (or not) the dataset into training and test set. The normality assumption was made for the classifier given the disease status, and the Youden's criterion considered for the detection of the optimal cutoff. Then, an ROC analysis with sample split was applied to assess the discriminant validity of the Italian version of the Control of Allergic Rhinitis and Asthma Test (CARATkids) questionnaire for children with asthma and rhinitis, for which recent studies may have reported liberal performance estimates.
Results The simulation study showed that both single split and cross-validation (CV) provided unbiased estimators of sensitivity, specificity, and misclassification rate, therefore allowing computation of confidence intervals. For the Italian CARATkids questionnaire, the misclassification rate estimated by fivefold CV was 0.22, with 95% confidence interval 0.14 to 0.30, indicating an acceptable discriminant validity.
Conclusions Splitting into training and test set avoids overrating the test performance in ROC analysis. Validated through this method, the Italian CARATkids is valid for assessing disease control in children with asthma and rhinitis.
Weight-bearing MRI of the Lumbar Spine: Technical Aspects
Authors: Nordberg Cecilie Lerche , Hansen Bjarke Brandt , Nybing Janus Damm , Hansen Philip , Bliddal Henning , Griffith James F. , Fournier Gilles , Guglielmi Giuseppe , Boesen Mikael 
Published: November 2019

AbstractMagnetic resonance imaging (MRI) has an established role in the assessment of degenerative musculoskeletal conditions. However, conventional supine MRI findings often correlate poorly with clinical findings. Some patients experience accentuated back pain in the weight-bearing position. Therefore, supine MRI may underestimate the severity of degenerative spine findings. To try and improve the clinical validity of spine imaging, axial loading devices have been used with conventional supine MR imaging to simulate loading of the upright spine. More recently, upright weight-bearing MRI systems (0.25–0.6 T) were introduced, allowing images to be obtained in the standing or seated weight-bearing position and even during upright flexion or extension, rotation, or bending. Some scanners even enable capturing of real-time spinal movement. This review addresses the technical aspects and potential challenges of weight-bearing MRI, both in clinical practice and research.
Weight-bearing MRI of the Lumbar Spine: Spinal Stenosis and Spondylolisthesis
Authors: Hansen Bjarke Brandt , Nordberg Cecilie Lerche , Hansen Philip , Bliddal Henning , Griffith James F. , Fournier Gilles , Thorseth Ingrid , Guglielmi Giuseppe , Boesen Mikael 
Published: November 2019

AbstractSymptoms of degenerative lumbar spinal stenosis include back pain, radiculopathy, claudication, and muscular fatigue that tend to be predominant in the standing position or during walking. Lumbar spondylolisthesis is also a well-known cause of spinal stenosis, lateral recess, and neural foraminal narrowing that tends to become more severe in the upright position. This indicates a functional positional component of both spinal stenosis and spondylolisthesis. Lumbar spinal stenosis and spondylolisthesis are typically evaluated by magnetic resonance imaging (MRI) performed in the supine position with a pillow under the patient's lower limbs that slightly flexes the lumbar spine and ameliorates symptoms. Because these two entities tend to be aggravated in the upright position, it seems rational to also consider performing diagnostic imaging in these patients in the upright position. This article reviews the use of weight-bearing MRI for lumbar spinal stenosis and spondylolisthesis.