bluuebunny/crossref_metadata_2025_split huggingface dataset:
Looking Backward, Moving Forward
Authors: Abzug Robert H. 
Published: December 2020

Abstract
May turns to writing a fond and interpretively acute short book on his relationship to Paul Tillich-Paulus—and runs into difficulties with Hannah Arendt’s own memoir of her marriage. He then publishes The Courage to Create. May becomes more and more alienated in New York, feeling drawn to California and its more open and psychologically progressive atmosphere. He accepts a Regents Professorship at the University of California Santa Cruz, but has a mixed time because of health problems and marital strife with Ingrid. At the same time, May becomes more critical of the more narcissistic and quick-fix nature of some of the humanistic psychology movement, and he along with others convene as theory conference to establish a more serious and scientifically sound basis for the movement,also one that focused on social issues in addition to personal well-being. By fall 1975, he moves to Tiburon, California, and separates from Ingrid.
Mg–Sr–Nd Isotopic Insights into Petrogenesis of the Xiarihamu Mafic–Ultramafic Intrusion, Northern Tibetan Plateau, China
Authors: Chen Lie-Meng , Song Xie-Yan , Hu Rui-Zhong , Yu Song-Yue , Yi Jun-Nian , Kang Jian , Huang Kang-Jun 
Published: December 2020

AbstractTo characterize the integrated magmatic processes for magma plumbing systems from mantle sources to magma chambers, we present Mg–Sr–Nd isotopic data for a representative mafic–ultramafic intrusion in Xiarihamu, northern Tibetan Plateau, China. The intrusion hosts the largest magmatic Ni–Cu sulfide deposit in an orogenic setting in the world and is composed predominantly of harzburgite, orthopyroxenite, websterite, and gabbronorite. The cumulate harzburgites have relatively low δ26Mg of orthopyroxene (–0·49 to –0·34‰) and moderately high (87Sr/86Sr)i and positive εNd(t) values (0·7067–0·7080 and +0·4 to +1·8, respectively). Most of the orthopyroxenites, websterites, and gabbronorites have slightly higher δ26Mg of orthopyroxene (–0·34 to –0·21‰) and higher (87Sr/86Sr)i and lower εNd(t) values (0·7087–0·7118 and –4·0 to –1·4, respectively) than the harzburgites. On the other hand, marginal facies (i.e. a few centimeters to meters from the contact between the intrusion and country rocks of schist, gneiss, and marble) including websterite and gabbronorite are marked by low δ26Mg of orthopyroxene (–0·44 to –0·33‰) and extremely high (87Sr/86Sr)i and negative εNd(t) values (0·7127–0·7172 and –5·4 to –4·8, respectively). The relatively low δ26Mg, moderately high (87Sr/86Sr)i, and positive εNd(t) of the harzburgites are best interpreted by inheritance from the mantle source, which was previously metasomatized by subducted Mg-rich carbonates. Given the fact that the solidus of carbonated mantle is significantly lower than that of volatile-free mantle, mantle metasomatism by carbonates may be critical to generate voluminous mafic magmas and to form the giant Xiarihamu Ni–Cu deposit and other magmatic sulfide deposits in convergent settings worldwide. The relatively high δ26Mg, high (87Sr/86Sr)i, and low εNd(t) of most orthopyroxenites, websterites, and gabbronorites were produced by extensive contamination of isotopically heavy crustal rocks in a deep-seated magma chamber. The slightly low δ26Mg, extremely high (87Sr/86Sr)i and negative εNd(t) of the marginal facies, compared with other websterites and gabbronorites, were governed by assimilation of local low-δ26Mg country rocks (e.g. gneiss and marble) at the Xiarihamu magma chamber during emplacement. These observations indicate that mafic–ultramafic cumulates away from marginal facies can preserve their primitive Mg–Sr–Nd isotope signatures inherited from deep magma chambers, even from mantle sources, with negligible crustal contamination during magma ascent and emplacement. These findings for the first time, to our knowledge, provide observational evidence to characterize the integrated magmatic processes of a single magma plumbing system from deep mantle source to magma chambers, which sheds light on the petrogenesis and mineralization of mafic–ultramafic intrusions.
Honduras: two hurricanes, COVID-19, dengue and the need for a new digital health surveillance system
Authors: Durón Reyna M , Sánchez Eduardo , Choi Joon Nak , Peralta Guímel , Ventura Sandra Gómez , Soto Ramón J , Rodríguez Gaspar , Ahrens Chad , Farach Efraín , Figueroa Julio , Pineda Gracia , Romero Aldo , Rodríguez Oswaldo , Discua David , Salgado Javier 
Published: December 2020

Abstract
A recently published article of this journal stated that informatics solutions can guide better public health decision-making during the COVID 19 (Coronavirus Disease 2019) pandemic. Honduras is a country facing the COVID-19 pandemic with a weak health surveillance system while also fighting a dengue epidemic and the aftermath of two hurricanes that struck its territory in November 2020. In response, we as academics started a COVID-19 and Dengue Observatory combining several technological platforms and developing multidisciplinary research to help the country navigate the crisis. Mapping the pandemic and the natural disasters showed us that technology can be applied toward epidemiology to benefit communities in a time of need by quickly building a basic digital health surveillance system for Honduras.
Differences between the productivities of organic and conventional dairy farms in Denmark
Authors: Aigner Lorenz , Asmild Mette 
Published: December 2020

AbstractThe study compares the productivity change over time of organic and conventional dairy farms in Denmark between 2011 and 2018 using data envelopment analysis, and aims to identify which technology is superior. Productivity changes and the differences between organic and conventional frontiers in each year for observations from each group are calculated for each technology separately using the Malmquist Productivity Index and its components. Then, a recently developed permutation test is used to analyse the statistical significance of the results. The analysis identifies volatility in the (economic) production possibilities, which is likely related to changes in milk prices caused by geopolitical events, which the conventional technology seems to be more susceptible to. Furthermore, the organic technology on average became superior for conventional farms in 2015. Farm level analysis identifies characteristics of the input–output mix of the farms, indicating whether a farm could benefit from conversion to the other technology.
Integrated transcriptomic and metabolomic analyses reveal regulation of terpene biosynthesis in the stems of Sindora glabra
Authors: Yu Niu , Chen Zhaoli , Yang Jinchang , Li Rongsheng , Zou Wentao 
Published: December 2020

Abstract
Sesquiterpenes are important defensive secondary metabolites that are synthesized in various plant organs. Methyl jasmonate (MeJA) plays a key role in plant defense responses and secondary metabolism. Sindora glabra Merr. ex de Wit produces abundant sesquiterpenes in its trunks, and was subjected to investigation after MeJA treatment in order to characterize the molecular mechanisms underlying the regulation of sesquiterpene biosynthesis in plant stems and further our understanding of oleoresin production in trees. A total of 14 types of sesquiterpenes in the stems of mature S. glabra trees were identified. The levels of two sesquiterpenes, α-copaene and β-caryophyllene, significantly increased after MeJA treatment. Differentially expressed genes involved in terpenoid backbone biosynthesis were significantly enriched over time, while the expression of JAZ genes involved in the jasmonic acid signaling pathway and TGA genes involved in the salicylic acid signaling pathway was significantly enriched at later time points after treatment. Two new terpene synthase genes, SgSTPS4 and SgSTPS5, were also identified. Following MeJA treatment, the expression levels of SgSTPS1, SgSTPS2 and SgSTPS4 decreased, while SgSTPS5 expression increased. The major enzymatic products of SgSTPS4 were identified as β-elemene and cyperene, while SgSTPS5 was identified as a bifunctional mono/sesquiterpene synthase that could catalyze farnesyl pyrophosphate to produce nine types of sesquiterpenes, including α-copaene and β-caryophyllene, while SgSTPS5 could also use geranyl pyrophosphate to produce geraniol. Dramatic changes in the amounts of α-copaene and β-caryophyllene in response to MeJA were correlated with transcriptional expression changes of SgSTPS5 in the wood tissues. In addition, the transcription factors MYB, NAC, ARF, WRKY, MYC, ERF and GRAS were co-expressed with terpene biosynthesis genes and might potentially regulate terpene biosynthesis. Metabolite changes were further investigated with UPLC-TOF/MS following MeJA treatment. These results contribute to the elucidation of the molecular mechanisms of terpene biosynthesis and regulation as well as to the identification of candidate genes involved in these processes.
Massive complicated secondary inguinal mycetoma: a case series
Authors: Ezaldeen Eshraga Abakar , Ahmed Eiman Siddig , Fahal Ahmed Hassan 
Published: December 2020

Abstract
Mycetoma is a chronic subcutaneous granulomatous disease of the soft tissue and extremities. Herein we report four cases of mycetoma caused by different agents, two caused by Madurella mycetomatis, with Actinomadura madurae and Streptomyces somaliensis affecting the others. These lesions originated at different sites but eventually spread to the inguinal region. The exact mechanism for such spread is still unknown and the clinical presentation of our case series was distinctive and required intensive follow-up for appropriate management.
A Novel Marking Technique for Descemet Membrane Endothelial Graft Using an Ophthalmic Viscoelastic Device
Authors: Or Lior , Krakauer Yonit , Sorkin Nir , Knyazer Boris , Ashkenazy Zach , Gushansky Kostya , Dubinsky-Pertzov Biana , Gazit Inbal , Einan-Lifshitz Adi 
Published: December 2020

Purpose:
To describe the viscoelastic marking technique, a novel marking technique of Descemet membrane endothelial keratoplasty (DMEK) grafts that enables usage of a single donor cornea for 2 surgeries—one that uses Descemet membrane and endothelium (DMEK) and the other using the stroma and Bowman layer.

Methods:
A retrospective case analysis was performed on 26 eyes of 26 consecutive patients who underwent DMEK using the “viscoelastic marking technique.” In this novel technique, an ophthalmic viscoelastic device (Healon 5) is placed over the endothelial side. Descemet membrane is then folded in half over the ophthalmic viscoelastic device with the stromal side up, and the F mark is drawn on the stromal side of the folded Descemet membrane. Primary outcome was best spectacle-corrected visual acuity, and secondary outcomes included graft detachment and rebubble rate, graft failure, and endothelial cell density.

Results:
Mean best spectacle-corrected visual acuity improved significantly from 1.0 ± 0.7 logarithm of the minimum angle of resolution (LogMAR) before the surgery to 0.9 ± 0.7 LogMAR, 0.5 ± 0.6 LogMAR, 0.4 ± 0.2 LogMAR, and 0.4 ± 0.4 LogMAR at 1, 3, 6, and 12 months after surgery, respectively. Seven eyes (27%) had partial graft detachment that required air injection. Primary failure occurred in 3 eyes (11%). There were no free-floating donors or recognized inverted donors. The endothelial cell density loss at 12 months after surgery was a cell-loss rate of 38.3%.

Conclusions:
The viscoelastic marking technique is a simple, approachable, and safe technique for marking DMEK grafts while preserving the anterior cornea for additional surgery.
Active Middle Ear Implant Patient Outcomes With Adaptive Feedback Canceller
Authors: Peixoto Maria Conceição , Pratas Rui , Miranda Cristina , Bento Mafalda , Oliveira Susana , Correia da Silva Victor 
Published: December 2020

Objective:
Evaluation of the audiological patient performance with an upgrade of the firmware from the fixed feedback canceller (FFC) to the adaptive feedback canceller (AFC) on an active middle ear implant.

Study Design:
Retrospective observational nonrandomized group study.

Setting:
Private hospital.

Patients/Intervention(s):
From March 2018 to September 2019, 15 patients implanted with an active middle ear implant, with 6 or more months of experience with a FFC system, were upgraded to an AFC algorithm.

Main Outcome Measure(s):
Functional gain, speech perception in silence and in noise, and sound localization capacities were examined. Feedback reduction was also analyzed.

Results:
Thirteen patients were analyzed. Pure tone audiometric evaluation with FFC (mean value of 48.02 dB) compared with AFC at 1 (mean value of 49.12 dB) and 6 months (mean value of 42.75 dB) revealed no statistically significant differences (p = 0.889 and p = 0.358 respectively).
In speech discrimination in silence, clinically relevant improvements were observed with AFC at 1 and 6 months, with a mean value of 41.5 and 38.3 dB, respectively (p = 0.03 and p = 0.021 correspondingly). In speech discrimination in noisy environments, we observed an improvement of the different conditions tested. No differences were found in localization capacities between FFC and AFC at the two different moments of evaluation.

Conclusions:
AFC is more effective than FFC in cancelling feedback and improving sound quality, allowing for better speech understanding in silence and in noise.
Airway management in the critically ill
Authors: Myatra Sheila Nainan 
Published: December 2020

Purpose of review
To provide an evidence-based approach to improve first pass success in tracheal intubation while maintaining patient safety in the critically ill.

Recent findings
Despite advances in the management of critically ill patients, tracheal intubation in these patients remains a high-risk procedure associated with increased morbidity and mortality. Recent interventions to enhance patient safety and improve first pass success in tracheal intubation emphasize reducing repeated attempts at tracheal intubation, oxygen desaturation and cardiovascular collapse during airway management by optimizing patient physiology to mitigate risks and reduce complications. These include various strategies to improve peri-intubation oxygenation like use of noninvasive ventilation, high flow nasal cannula oxygen and gentle mask ventilation between induction of anesthesia and laryngoscopy; use of a videolaryngoscope and a bougie; careful selection of drugs including neuromuscular blocking agent; improved strategies to avoid haemodynamic collapse; rescue oxygenation strategies and human factor considerations.

Summary
Recognizing the challenges and using the appropriate interventions to improve first pass tracheal intubation success, while maintaining patient safety are essential during tracheal intubation in critically ill patients. This review will provide recommendations based on the current evidence, various guidelines and expert opinion in the field. Further research will help us better understand the best strategies to improve patient outcomes.
Micronutrients early in critical illness, selective or generous, enteral or intravenous?
Authors: Berger Mette M. , Manzanares William 
Published: December 2020

Purpose of review
Micronutrients have essential antioxidant and immune functions, while low blood concentrations are frequently observed in critically ill patients. This has led to the concepts of complementation, repletion, or even pharmacological supplementation. Over the last three decades, many clinical studies have tested the latter strategy, with controversial or negative results. Therefore, this review aims at evaluating micronutrient-related interventions that are mandatory or need to be assessed in future trials or clinical registries in all or specific critically ill patients.

Recent findings
In the critically ill, low plasma/serum micronutrient levels not always reflect a true deficiency in the absence of demonstrable losses. Current practices of micronutrient provision and monitoring in critical care, vary substantially across the world. Also, recent clinical trials testing high dose as monotherapy (selenium, thiamine, vitamin C, vitamin D) or in combination have failed to demonstrate clinical benefits in sepsis. However, these studies have not applied a physiological integrative approach of micronutrient action.

Summary
Micronutrients are essential in nutrition but their administration and monitoring are difficult. So far, different well designed RCTs on intravenous and oral high dose micronutrient supplementation have been conducted. Nevertheless, very high-dose single micronutrients cannot be advocated at this stage in sepsis, or any other critical condition. By contrast, studies using combination of moderate doses of micronutrients in specific diseases, such as burns and trauma have been associated with improved outcomes. Intravenous administration seems to be the most efficient route. Future clinical trials need to integrate the physiology underlying the interconnected micronutrient activity, and choose more specific primary and secondary endpoints.
Global health disparities in childhood cancers
Authors: Lubega Joseph , Kimutai Robert L. , Chintagumpala Murali M. 
Published: December 2020

Purpose of review
The high cure rates of children with cancer in high-income countries (HICs) are due to the impact of biomedical innovations on children with highly fatal diseases. We discuss why these innovations have not benefitted most children with cancer globally and propose broad strategies to reduce these disparities.

Recent findings
Over 85% of children with cancer in HIC are cured while less than 20% in many low-income countries survive the disease. Hence, childhood cancer survival is poor globally since over 80% of children with cancer live in low-income and middle-income countries (LMICs). Inadequate skilled workforce and health infrastructure across all disciplines of pediatrics in LMIC are the main reasons for these disparities. Although biological differences may contribute to these disparities as well, many are unconfirmed because they are confounded by differences in referral patterns and clinical capacity. HIC partnerships with LMIC that focus on locally based pediatrics training and clinical infrastructure building are beginning to close the gap.

Summary
Pediatric oncology is symbolic of the significant disparities in childhood survival arising from poverty, inadequate pediatric infrastructure, and skilled workforce in LMIC. Partnerships with HIC that build multidisciplinary pediatrics capacity and clinical infrastructure are beginning to make transformative improvements.
Only the Lonely: Expression of Proinflammatory Genes Through Family Cancer Caregiving Experiences
Authors: Kim Youngmee , Cole Steve W. , Carver Charles S. , Antoni Michael H. , Penedo Frank J. 
Published: December 2020

ABSTRACT

Objective
The experience of cancer elicits not only turmoil but also resilience in the family, which has been related to psychological adjustment and physical health of family caregivers. The biological pathways linking family cancer caregiving to health, however, remain poorly understood. This study examined the extent to which psychological risk and resilience factors related to a proinflammatory gene expression profile (conserved transcriptional response to adversity, or CTRA) among caregivers during the first-year postdiagnosis of a patient with colorectal cancer.

Methods
A total of 41 caregivers (mean age = 54 years, 74% female, 40% Hispanic) provided psychological data and peripheral blood samples around 4 and 12 months after diagnosis. Mixed regression models controlling for demographic and biometric factors were used to test the associations of caregiver CTRA gene expression with caregiving stress, loneliness, and lack of social support (risk factors), as well as benefit finding and meaning (resilience factors).

Results
When individually tested, all but benefit finding were significantly related to CTRA (R
2 ≥ 0.112, p < .045). When adjusted for other factors in either the risk or resilience group, loneliness, social support, and meaning effects remained significant (R
2 ≥ 0.120, p < .041). When all study factors were simultaneously adjusted (R
2 = 0.139), only loneliness remained significant (p = .034).

Conclusions
Findings suggest that caregiving-related transcriptional effects seem to be most pronounced when caregivers experience low social support and loneliness, as well as little meaning or purpose in their caregiving. These findings suggest that the development of new intervention strategies that prioritize reductions in caregiver loneliness may favorably impact biological mechanisms related to caregiver health.
Age and job-specific skill obsolescence: the moderating effects of human resource practices
Authors: Yue Lin-Yang , Huang Wei-de 
Published: December 2020

PurposeThis paper aims to examine theJ-shaped relationship between age and job-specific skill obsolescence (JSSO), and the differential moderating effects of development and maintenance HR practices on this relationship.Design/methodology/approachRegression models of survey data obtained from a sample of 722 Chinese knowledge workers were used to test the hypotheses.FindingsThe results show that among women age and JSSO areJ-shaped related and the relationship weakens under high development HR practices; while among men theJ-shaped age-JSSO relation is significant only under low maintenance HR practices.Research limitations/implicationsThis research is subject to the cross-sectional design, and the sample is restricted to knowledge workers.Originality/valueThis study advances previous studies that hold a linear (positive or negative) age-JSSO relationship by theorizing and testing aJ-shaped one. The differentiated moderating effects of two bundles of HR practices proved improves our knowledge about how to use HR practices appropriately to sustain employee work competency in the context of workforce aging.
Digitalization of the buyer–seller relationship in the steel industry
Authors: Salo Jari , Tan Teck Ming , Makkonen Hannu 
Published: December 2020

Purpose
The purpose of this paper is to cast light on the nature of the digitalization process that occurs when digital technologies are adopted in buyer–seller relationships.

Design/methodology/approach
The study features a case study from the steel processing industry.

Findings
The present research builds on and extends the interaction approach to the context of buyer–seller relationship digitalization process. The study explicates the interrelated elements of digital infrastructure, digital communication and degree of digitalization of the buyer–seller relationship.

Research limitations/implications
The study aims at theoretical generalization and thus produces conceptual understanding that is to some extent applicable to various contexts. The generalization of the empirical insights to other process-focused industries is to some extent possible. However, further research in versatile empirical contexts is needed to validate the results.

Practical implications
For managers, the study presents a success case of digital technologies use for improving a buyer–seller relationship.

Originality/value
The originality of the present research is in the way it depicts how a buyer–seller relationship is gradually digitalized in successive digital technology adoptions, that is, a virtuous cycle of digitalization, that creates and alters the digital infrastructure and digital communication processes between the buyer and the seller resulting in different outcomes (degrees of digitalization in the buyer–seller relationship).