bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol
Authors: Yan Yan , Sheng Ru-ya , Wang Yu , Zhang Chun-hong 
Published: September 2020

Abstract
Background: Acupuncture is a widely used alternative and complementary therapy. Functional Magnetic Resonance Imaging (fMRI) is an important technique to explore the underlying mechanism of acupuncture, and the task-based fMRI can reflect the instant effects or sustained effects of acupuncture in the brain. This scoping review aims to summarize the characteristics of acupuncture mechanism studies employing Task-based fMRI and conclude a reference for future studies.Methods/design: This review will follow the Guidance for Conducting Systematic Scoping Reviews. Eligible articles will be collected from 6 databases (PubMed, Embase, Cochrane, CNKI, WanFang and VIP) with the related keywords such as “Acupuncture” and “fMRI” and those articles should be published from the establishment of the database to June 30th, 2020. Each research step will involve at least two reviewers. The PRISMA-ScR (Preferred Reporting Items for Systemic Reviews and Meta-Analysis Extension for Scoping Reviews) will be used to organize the review.Discussion: This review aims to clarify the extent of acupuncture mechanism studies employing task-based fMRI. It is supposed to make a critical evaluation or to propose quality requirements for future studies by summarizing the objectives and designs of eligible studies. What’s more, directional suggestions will be provided for further studies.Scoping review registration: Open Science Framework https://osf.io/zjrdc/.
Treatment of Coagulopathy in COVID-19 Patients: A scoping review
Authors: MORI HIROTAKA , Ohkawara Hiroshi , Togawa Ryuichi , Rikimaru Mami , Shibata Yoko , Ikezoe Takayuki 
Published: September 2020

Abstract
Background: Coagulopathy, including disseminated intravascular coagulation, is frequently noted in patients with coronavirus infection disease 2019 (COVID-19). Recently, a number of articles on this topic have been reported.Objective: The aim of this study is to identify existing gaps where further research on anticoagulants in COVID-19 patients with coagulopathy needs to be done.Methods: We used the PRISMA Extension for Scoping Reviews. The protocol was registered on May 21, 2020, before conducting this review. MEDLINE, CENTRAL, WHO-ICTRP, ClinicalTrial.gov and PROSPERO were used.Result: Eight studies were included; six studies were already published and two are ongoing. The reported results for three publications were from case series, three were from retrospective cohorts and two were from randomized controlled trials. Eight studies examined the effectiveness of low molecular weight heparin (LMWH), of which seven studies used a prophylactic dose and four studies used a therapeutic dose of LMWH. A prophylactic or therapeutic dose of unfractionated heparin was investigated in four and three studies, respectively. No recombinant human soluble thrombomodulin was investigated. Conclusion: The anticoagulants are limited to heparinoids, and the study designs were of low quality. Further studies with an improved design are needed to compare other available anticoagulants.
Stöfflerite, (Ca,Na)(Si,Al)4O8 in the hollandite structure: A new high-pressure polymorph of anorthite from martian meteorite NWA 856
Authors: Tschauner Oliver , Ma Chi , Spray John G. , Greenberg Eran , Prakapenka Vitali B. 
Published: September 2020

AbstractWe present the crystal structure, composition, and occurrence of stöfflerite, the naturally occurring Ca-aluminosilicate with hollandite-type structure. Stöfflerite is a high-pressure polymorph of anorthite and an approved mineral. The type material was found in the shergottitic martian meteorite Northwest Africa 856. Type stöfflerite (Sto60Lin40) assumes space group I4/m with unit-cell dimensions a = 9.255(1) Å, c = 2.742(3) Å, V = 235.1(2) Å3, and Z = 2.
Thermal expansion of minerals in the pyroxene system and examination of various thermal expansion models
Authors: Hovis Guy L. , Tribaudino Mario , Leaman Amanda , Almer Christine , Altomare Caitlin , Morris Matthew , Maksymiw Nicole , Morris Derek , Jackson Kevin , Scott Brian , Tomaino Gary , Mantovani Luciana 
Published: September 2020

AbstractTo examine the effects of chemical composition on thermal expansion in the pyroxene mineral group, X-ray diffraction data have been collected from room temperature to ~925 °C on a chemically diverse group of 13 pyroxenes including four orthorhombic and nine monoclinic samples. Additionally, resulting unit-cell volumes computed from the XRD data have proven to be good tests for a large number of thermal expansion models; the physical model by Kroll and coworkers and the empirical one by Fei have been found to be especially useful. Modeling also has allowed the connection of present data, collected at temperatures above 25 °C, to the volume data of other workers for much lower temperatures, well below 0 °C, and also extrapolation of values for volume and thermal expansion well beyond the measurement range.We have found for orthopyroxenes that Fe2+-Mg2+ substitution has little effect on thermal expansion coefficients for volume. For clinopyroxenes, however, greater thermal expansion occurs in Ca2+-(diopside, augite, hedenbergite, johannsenite) than in Li+-(spodumene) or Na+-bearing members (jadeite, aegirine, kosmochlor). Present data support the observation that differences in volume thermal expansion relate primarily to differences in expansion along the b crystallographic axis. This apparently is due to the greater concentration of M1 polyhedra along the b crystallographic axis, where expansion differences can be related to the shared O1-O1 polyhedral edge and inter-oxygen repulsion that is made easier by divalent, as opposed to trivalent, cation occupancy of the M1 crystallographic site.
Current Scenario and Future Prospect in the Management of COVID-19
Authors: Borah Pobitra , Deb Pran Kishore , Deka Satyendra , Venugopala Katharigatta N. , Singh Vinayak , Mailavaram Raghu Prasad , Kalia Kiran , Tekade Rakesh Kumar 
Published: September 2020

:
The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of
risk assessment, rapid spreading ability, and propensity to precipitate severe disease in comorbid
conditions. In an attempt to fulfill the demand for prophylactic and treatment measures
to intercept the ongoing outbreak, the drug development process is facing several obstacles
and renaissance in clinical trials, including vaccines, antivirals, immunomodulators,
plasma therapy, and traditional medicines. This review outlines the overview of SARS-CoV-2
infection, significant recent findings, and ongoing clinical trials concerning current and future
therapeutic interventions for the management of advancing pandemic of the century.
Evaluation of Gastroprotective Activity of Linoleic Acid on Gastric Ulcer in a Mice
Model
Authors: Martins José L.R. , Silva Dayane M. , Gomes Emerson H. , Fava Samuel A. , Carvalho Murilo F. , Macedo Isaac Y.L. , Gil Eric S. , Ghedini Paulo C. , Rocha Fábio F. , Silva Osmar N. , Fajemiroye James O. , Pinto Emerith M.H. , Costa Elson A. 
Published: September 2020

Background:
Gastric ulcer has been a major cause of morbidity and mortality worldwide, and it has been
linked to factors such as nutritional deficiency, smoking, stress, and continuous intake of non-steroidal anti-inflammatory
drugs (NSAIDs). The search for new anti-ulcer therapeutic agents has been the subject of several studies. Recently, the
gastroprotective effect of Celtis iguanaea has been reported, with linoleic acid (LA) responsible for many of the
therapeutic effects of this medicinal plant.

Aim:
This study aims to investigate the gastroprotective activity and the possible mechanisms in which LA may be
involved, through different experimental assays in mice.

Methods:
The gastroprotective activity LA was evaluated in the ulcer induced by indomethacin, HCl/EtOH, hypothermicrestraint stress and pyloric ligation. For the gastroprotective mechanisms investigation the quantification of the volume
(mL), pH and total acidity of gastric secretion were considered.

Results:
The oral administrations of 25 mg/kg, 50 mg/kg or 100 mg/kg of body weight of LA were capable of protecting
the gastric mucosa against HCl/ethanol (10 mL/kg p.o.), and oral administrations of 50 mg/kg LA showed protection from
ulcers induced by indomethacin, hypothermic-restraint stress and pyloric ligation.

Conclusion:
The results of this study show the gastroprotective role of LA in gastric mucosal damage induced by all
assayed distresses. The observed gastroprotection possibly occurs due to the mediated increase of mucosal defensive
factors.
Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon
Authors: Singh Nitika , Yarla Nagendra Sastry , Siddiqi Nikhat Jamal , de Lourdes Pereira Maria , Sharma Bechan 
Published: September 2020

Background:
Citrus limon, a Mediterranean-grown citrus species of plants belonging to
the Rutaceae family, occupies a place of an impressive range of food and medicinal uses with considerable
value in the economy of the fruit of the country. Citrus fruits are economically important with
large-scale production of both the fresh fruits and industrially processed products. The extracts and
phytochemicals obtained from all parts of C. limon have shown immense therapeutic potential because
of their anticancer, anti-tumor and anti-inflammatory nature, and also serve as an important
ingredient in the formulation of several ethnic herbal medicines. These properties are mediated by the
presence of different phytochemicals, vitamins and nutrients in the citrus fruits.

Material and Methods:
The methods involved in the preparation of the present article included the
collection of information from various scientific databases, indexed periodicals, and search engines
such as Medline Scopus google scholar PubMed, PubMed central web of science, and science direct.

Results:
This communication presents an updated account of different pharmacological aspects of C.
limon associated with its anti-oxidative, antiulcer, antihelmintic, insecticidal, anticancer, cytotoxic,
and estrogenic activities. In addition, C. limon extracts possess hepatoprotective, anti-hyperglycemic,
and antimicrobial properties. The present article includes the structure and function of different key
chemical constituents from different parts of C. limon. Also, the possible molecular mechanisms of
actions of bioactive compounds from C. limon are displayed.

Conclusion:
The traditional and ethno-medicinal literature revealed that C. limon is very effective in
different pathologies. Most of these compounds possessing antioxidant properties would be implicated
in offering health benefits by acting as potential nutraceuticals to humans with special reference to
disease management of health and disease.
Fluorinated-NHC Transition Metal Complexes: Leading Characters as Potential Anticancer Metallodrugs
Authors: Rufino-Felipe Ernesto , Colorado-Peralta Raúl , Reyes-Márquez Viviana , Valdés Hugo , Morales-Morales David 
Published: September 2020

:
In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and
medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized
and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives,
including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced
biological properties and turning them into excellent candidates for the development of novel metallodrugs.
Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and
their impact on cancer treatment.
Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An In vitro and In vivo Approach
Authors: Ajebli Mohammed , Eddouks Mohamed 
Published: September 2020

Aims:
The aim of the study was to investigate the effect of aqueous aerial part extract of
Mentha pulegium L. (Pennyrile) (MPAE) on arterial pressure parameters in rats.

Background:
Mentha pulegium is a medicinal plant used to treat hypertension in the Moroccon
population.

Methods:
In the current study, MPAE was prepared and its antihypertensive activity was pharmacologically
investigated. L-NAME-hypertensive and normotensive rats received MPAE (180 and 300
mg/kg) orally for six hours for acute experiment and during seven days for the sub-chronic treatment.
Thereafter, systolic, diastolic, mean arterial blood pressure and heart rate were evaluated. In
the in vitro experiment, isolated denuded and intact thoracic aortic rings were suspended in a tissue
bath system and the tension changes were recorded.

Results:
A fall in blood pressure was observed in L-NAME-induced hypertensive treated with
MPAE. The extract also produced a dose-dependent relaxation of aorta pre-contracted with NE and
KCl. The study showed that the vasorelaxant ability of MPAE seems to be exerted through the
blockage of extracellular Ca2+ entry.

Conclusion:
The results demonstrate that the extract of pennyrile exhibits antihypertensive activity.
In addition, the effect may be, at least in part, due to the dilation of blood vessels via blockage
of Ca2+ channels.
Simulation Analysis on Genomic Selection of Grouper (Epinephelus coioides) Breeding for Categorical Traits
Authors: Ma Zhiyuan , You Xinxin 
Published: September 2020

Background:
The basic principle of genome selection (GS) is to establish a model of genome
estimated breeding value (GEBV) by using single-nucleotide polymorphisms (SNPs) covering
the entire genome. Despite the decreasing cost of high-throughput genotyping, the GS strategy remains
expensive due to the need for phenotyping and genotyping for a large number of samples.
Simulation analysis of genome selection is a popular, lower-cost method to determine an optimal
breeding program of GS.

Objective:
To evaluate the utility of simulation data to study the influence of different factors on
algorithms. This could be helpful for developing genome selection breeding strategies, especially
for stress and resistance traits of fish.

Methods:
Real data of orange-spotted grouper (Epinephelus coioides) were obtained from a previous
genome-wide association study. Ammonia tolerance, different population sizes, SNP density,
QTL number, kinship (base mutation rate), and heritability were considered. All of the phenotypes
and genotypes were generated by AlphaSimR simulation software. Four genome selection algorithms
(gBLUP, rrBLUP, BayesA, and BayesC) were tested to derive GEBV, and their accuracies
(area under the curve, AUC) were compared.

Results:
In different scenarios, the AUC ranges from 0.4237 to 0.6895 for BayesA, 0.4282 to
0.6878 for BayesC, 0.4278 to 0.6798 for gBLUP, and 0.4346 to 0.6834 for rrBLUP. The mean AUC
of these four algorithms was not significantly different (0.547–0.548). The accuracies of the four
genome selection algorithms were similar but had different predictive performances in specific scenarios.
The gBLUP was most stable, and the rrBLUP was slightly better at predicting low heritability
traits. When the number of individuals was small, the BayesA and BayesC algorithms were more
robust.

Conclusion:
A practical GS scheme should be optimized in accordance with marker density, heritability,
and reference population size. Adequate preliminary research is necessary. The results provide
a framework for the design of genomic selection schemes in E. coioides breeding.
Disruptive Mood Dysregulation Disorder and its Impact on Rates of Bipolar Disorder among Children and Adolescents
Authors: Alghamdi Waleed A. 
Published: September 2020

Background:
In 2013, Disruptive Mood Dysregulation Disorder (DMDD) was introduced
in the DSM-5 in part to curb the rapid rise in the rates of bipolar diagnosis among children
and adolescents during the decade before the DSM-5 publication. DMDD proved to be a controversial
diagnosis for many reasons.

Objective:
This brief review aims to provide an overview of the DMDD diagnosis and its origins
and summarize available data on the impact of the introduction of the DMDD diagnosis on the rates
of bipolar disorder among children and adolescents.

Methods:
Multiple scientific databases were searched using the related terms “DMDD”, “Disruptive
Mood Dysregulation”, and “pediatric bipolar disorder” in combination with the terms “diagnosis”
and “impact”. The retrieved articles were reviewed carefully.

Results:
The DMDD diagnosis rates have steadily increased since its introduction. Furthermore,
available data show a decrease in the rates of bipolar disorder diagnosis among children and adolescents
over the past few years.

Conclusion:
The very limited available data since 2013 show a decline in the diagnosis of bipolar
disorder among children and adolescents. More time and further research are needed to more accurately
determine the impact of the DMDD diagnosis on the rates of bipolar disorder in this population.
IgE-Mediated Immune Response and Antibody-Mediated Rejection
Authors: Rascio Federica , Pontrelli Paola , Netti Giuseppe Stefano , Manno Elisabetta , Infante Barbara , Simone Simona , Castellano Giuseppe , Ranieri Elena , Seveso Michela , Cozzi Emanuele , Gesualdo Loreto , Stallone Giovanni , Grandaliano Giuseppe 
Published: September 2020

Background and objectives
Active antibody-mediated rejection is the main cause of kidney transplant loss, sharing with SLE the alloimmune response and the systemic activation of the IFN-α pathway. IgE-mediated immune response plays a key role in the development of SLE nephritis and is associated with IFN-α secretion. The aim of our study was to investigate IgE-mediated immune response in antibody-mediated rejection.

Design, setting, participants, & measurements
This was a cross-sectional study of 56 biopsy-proven antibody-mediated rejection study participants, 80 recipients with normal graft function/histology (control), 16 study participants with interstitial fibrosis/tubular atrophy, and six participants with SLE. We evaluated graft IgE deposition, tryptase (a mast cell marker), and CD203 (a specific marker of activated basophils) by immunofluorescence/confocal microscopy. In addition, we measured serum concentration of human myxovirus resistance protein 1, an IFN-α–induced protein, and anti-HLA IgE.

Results
We observed a significantly higher IgE deposition in tubules and glomeruli in antibody-mediated rejection (1766±79 pixels) and SLE (1495±43 pixels) compared with interstitial fibrosis/tubular atrophy (582±122 pixels) and control (253±50 pixels). Patients with antibody-mediated rejection, but not control patients and patients with interstitial fibrosis/tubular atrophy, presented circulating anti-HLA IgE antibodies, although with a low mean fluorescence intensity. In addition, immunofluorescence revealed the presence of both mast cells and activated basophils in antibody-mediated rejection but not in control and interstitial fibrosis/tubular atrophy. The concentration of circulating basophils was significantly higher in antibody-mediated rejection compared with control and interstitial fibrosis/tubular atrophy. MxA serum levels were significantly higher in antibody-mediated rejection compared with control and correlated with the extent of IgE deposition.

Conclusions
Our data suggest that IgE deposition and the subsequent recruitment of basophils and mast cells within the kidney transplant might play a role in antibody-mediated rejection.
Quantitative evaluation of retromolar space in adults with different vertical facial types:
Authors: Zhao Zuodong , Wang Qiuyu , Yi Ping , Huang Futing , Zhou Xiaohui , Gao Qianya , Tsay T. Peter , Liu Chang 
Published: September 2020

ABSTRACT

Objective
To investigate the differences in mandibular retromolar space among skeletal Class I subjects with different vertical divergence using cone-beam computed tomography (CBCT).

Materials and Methods
A total of 123 skeletal Class I patients (aged 20–40 years) were categorized into hypodivergent, normodivergent, and hyperdivergent groups based on S-N/Go-Me and facial height index (FHI). Mandibular retromolar space was measured at four planes parallel to the occlusal plane along the sagittal line and molar cuspal line, respectively. The mandibular retromolar space was compared among the three vertical groups.

Results
The hyperdivergent group had a significantly smaller mandibular retromolar space compared with the other two groups, while the hypodivergent group had the largest retromolar space. In addition, the hyperdivergent group had a larger number of subjects whose roots contacted the lingual cortex of the mandibular body.

Conclusions
The hyperdivergent group tends to exhibit the smallest mandibular retromolar space and highest risk of cortex contact. Clinicians should keep in mind that successful molar distalization requires sufficient retromolar space, especially for hyperdivergent subjects, which should be verified with CBCT.
O uso de ferramentas tecnológicas como comunidades de práticas por docentes de uma rede particular de ensino
Authors: Fleig Dal Forno Leticia , De Souza Machado Reginéa , Carnevale de Almeida Iara 
Published: September 2020

A internet tem sido usada nas escolas em larga escala e serve como nova forma de comunicação entre os docentes e os responsáveis pelos educandos das séries iniciais, especialmente de escolas particulares. Essa interatividade entre o docente da Educação Infantil com os responsáveis utilizando a rede social, em especial o aplicativo Whatsapp, pode ser otimizada pela Gestão do Conhecimento (GC). O objetivo deste estudo foi o de investigar se os docentes da Educação Infantil de uma rede de ensino privada utilizam as redes sociais enquanto recurso de comunicação entre docente e responsáveis, como uma proposta de Comunidade de Prática. A pesquisa caracteriza-se como aplicada, de cunho exploratório, com abordagem quantitativa. A pesquisa foi realizada numa rede de escolas particulares no Sul do Brasil, coletando um grupo para estudo, caracterizando como procedimento de estudo de caso, pois ocorreu a inserção do pesquisador para monitoramento em grupos de WhatsApp das escolas, bem como questionário online. Os dados obtidos foram coletados usando análise quantitativa, onde 1. Os dados obtidos pelas conversas forma depurados pelo (IRAMUTEQ). 2. O questionário online depurado no Google Forms. Os resultados indicaram que os docentes interagem nas redes sociais, no contato com os responsáveis, com potencial relação como uma proposta de Comunidades de Prática no contexto educacional.
cosecha de yerba mate en Misiones (Argentina)
Authors: Haugg Diana Elizabeth 
Published: September 2020

La Provincia de Misiones (Argentina) concentra el mayor volumen de producción y comercialización nacional de yerba mate, dinamizando un extenso mercado de trabajo agrario –asalariado y familiar; permanente y transitorio– que incluye indistintamente el uso de fuerza de trabajo de varones y mujeres; adultos/as y niños/as. A partir de la indagación y análisis de fuentes primarias y secundarias, en el presente trabajo se propone una aproximación en clave de género a ese mercado laboral. Esto revela que, si bien la evidencia empírica señala que las mujeres han estado históricamente presentes, el mercado de trabajo yerbatero-cosechero es un ámbito masculinizado en el que impera una cultura hegemónica masculina y, donde aun hoy, a pesar de la modificación de su situación histórica de “ayuda familiar”, el género femenino se encuentra subordinado al masculino incluso al compartir su condición de obrera rural con los varones.