bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns in Pain and Opiate Use after Endoscopic Sinus Surgery
Authors: Ndon Sifon , Spock Todd , Torabi Sina J. , Manes R. Peter 
Published: April 2020

ObjectiveTo evaluate postoperative opiate use and patients’ opinions regarding pain management after endoscopic sinus surgery (ESS).Study DesignCase series with planned data collection.SettingTertiary referral medical center.Subjects and MethodsWe prospectively evaluated postoperative opiate utilization in adults undergoing ESS over a 2‐year period at an academic medical facility. Exclusion criteria included use of nasal packing, intracranial or orbital procedures, tumor surgery, and any use of endoscopic drills. All patients underwent bilateral maxillary antrostomy, total ethmoidectomy, sphenoidotomy, and frontal sinusotomy with or without septoplasty. Patients were discharged with 30 oxycodone‐acetaminophen (5‐325 mg) and a survey assessing pain and narcotic/nonnarcotic use on postoperative days 0 to 7.ResultsA total of 64 patients completed surveys. Mean ± SD narcotic use over the 7‐day postoperative period was 7.7 ± 7.6 pills. Patients with high narcotic use (>6 pills total) had no differences in demographic or surgical factors from those with low use (≤6 pills) but did report a higher level of postoperative day 1 pain (4.8 ± 1.1 vs 2.0 ± 1.4, P <. 001). Narcotic use declined during this period, with <30% of patients requiring narcotics by postoperative day 3.ConclusionOur results support reduced opiate prescription and encouragement of nonnarcotic use after ESS without compromising effective pain management.
A scoring system based on computed tomography for the correct diagnosis of xanthogranulomatous cholecystitis
Authors: Ito Ryota , Kobayashi Takashi , Ogasawara Gou , Kono Yoshiharu , Mori Kazuhiko , Kawasaki Seiji 
Published: April 2020

BackgroundXanthogranulomatous cholecystitis (XGC) is an uncommon variant of chronic cholecystitis. The differential diagnoses of XGC include gallbladder cancer (GBC), adenomyomatosis, and actinomycosis of the gallbladder.PurposeTo assess the usefulness of computed tomography (CT) findings in the diagnosis of XGC and differentiation from GBC.Material and MethodsWe retrospectively assessed the pathological and radiological records of 13 patients with pathologically proven XGC and 33 patients with GBC.ResultsSignificant differences were observed for the following five CT findings: diffuse wall thickening (XGC = 85%, GBC = 15%, P < 0.01); absence of polypoid lesions (XGC = 100%, GBC = 48%, P < 0.01); intramural nodules or bands (XGC = 54%, GBC = 9%, P < 0.01); pericholecystic infiltration (XGC = 69%, GBC = 9%, P < 0.01); and pericholecystic abscess (XGC = 23%, GBC = 0%, P = 0.018). We defined the scoring system based on how many of the five CT findings were observed. Our scoring system, which included these findings, revealed that patients with three or more findings had sensitivity of 77% (95% confidence interval [CI] = 57–87) and specificity of 94% (95% CI = 86–98).ConclusionOur scoring system can assist in the differentiation of XGC from GBC.
Bone Bruise Distribution Patterns After Acute Anterior Cruciate Ligament Ruptures: Implications for the Injury Mechanism
Authors: Shi Huijuan , Ding Li , Jiang Yanfang , Zhang Haocheng , Ren Shuang , Hu Xiaoqing , Liu Zhenlong , Huang Hongshi , Ao Yingfang 
Published: April 2020

Background: Bone bruises observed on magnetic resonance imaging (MRI) after an anterior cruciate ligament (ACL) injury could provide significant information about ACL injury mechanisms. Purpose/Hypothesis: The purpose of this study was to investigate common bone bruise patterns after an ACL injury. It was hypothesized that the most common bone bruise distribution pattern would be only the lateral side of both the femur and tibia. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Knee MRI scans of patients who underwent acute ACL reconstruction from August 2016 to August 2018 at our institution were selected. Imaging sequences in the sagittal and coronal planes were used for determining the bone bruise location in the lateral-medial and anterior-posterior directions, respectively. The presence, location, and intensity of bone bruises within specific compartments of the tibia and femur were documented. The relative bone bruise patterns of the tibia and femur were classified and analyzed. Results: A total of 207 patients (165 men, 42 women) met the inclusion criteria from a total of 4209 ACL reconstruction cases. The most common relative bone bruise pattern was located on only the lateral side of both the femur and the tibia (44.4%), followed by the lateral and medial sides of both the femur and tibia (29.0%). For the pattern found on the lateral and medial sides of both the femur and tibia, the bone bruises on only the lateral side of both the tibia and femur were more severe ( P < .001 and P < .001, respectively) and more anterior ( P < .001 and P < .001, respectively) than those on only the medial side. Conclusion: The most common relative bone bruise pattern observed was on only the lateral side of both the tibia and femur. Bone bruises on the lateral side were more severe than those on the medial side in patients with bone bruises on the lateral and medial sides of both the femur and tibia. Anterior translation of the tibia relative to the femur occurred during an ACL injury based on the location of bone bruises in the anterior-posterior direction.
Thermoelectric Effect in a Correlated Quantum Dot Side-Coupled to Majorana Bound States
Authors: Chi Feng , Fu Zhen-Guo , Liu Jia , Li Ke-Man , Wang Zhigang , Zhang Ping 
Published: April 2020

AbstractWe theoretically study the thermoelectric effect in a hybrid device composed by a topological semiconducting nanowire hosting Majorana bound states (MBSs) and a quantum dot (QD) connected to the left and right non-magnetic electrodes held at different temperatures. The electron-electron Coulomb interactions in the QD are taken into account by the non-equilibrium Green’s function technique. We find that the sign change of the thermopower, which is useful for detecting the MBSs, will occur by changing the QD-MBS hybridization strength, the direct overlap between the MBSs at the opposite ends of the nanowire, and the system temperature. Large value of 100% spin-polarized or pure spin thermopower emerges even in the absence of Zeeman splitting in the QD or magnetic electrodes because the MBSs are coupled to electrons of only one certain spin direction in the QD due to the chiral nature of the Majorana fermions. Moreover, the magnitude of the thermopower will be obviously enhanced by the existence of MBSs.
Research capacity of Australian and New Zealand emergency medicine departments
Authors:   on behalf of the ACEM Clinical Trials Network, Walker Katie , Tan Shijie Ian , Fatovich Daniel , Watkins Gina , Stephenson Melanie , Ting Joseph , Whittome Richard , Wang Wei , Knott Jonathan 
Published: April 2020

Abstract
Background
Large, multicentre studies are required in emergency medicine to advance clinical care and improve patient outcomes. The Australasian College for Emergency Medicine clinical trials network is available to researchers to assist with facilitating large, multicentre research. However, there is no current information about the research capacity of emergency departments (EDs) in Australia and New Zealand.

Methods
All EDs accredited for emergency medicine training in Australia and New Zealand were eligible to participate. Research leads or ED directors were invited via email and telephone to complete a survey. Data were collected regarding the presence of a research lead; their research experience; available research resources including colleagues, funding, departmental paid research time; publications; and research culture.

Results
One hundred and twelve responses were received on behalf of 122 (84%) sites (10 satellite plus main) from a possible 143 sites with all types of hospitals and regions represented. Research leads were identified at 66 (59%) sites; 32 (29%) had a director of emergency medicine research. A wide range of research was underway. Ninety-six sites (66%) contributed data to multicentre projects. Twenty-one centres (17%) were highly productive with multiple resources (skilled colleagues, funding, staffing), a positive research culture and high-volume output. Sixty to seventy centres (50–58%) had limited resources, experienced an unsupportive research culture and authored manuscripts infrequently. Paid time for research directors was associated with increased research outputs.

Discussion
ACEM sites have the capacity to undertake large multicentre studies with a varied network of sites and researchers. While some sites are well equipped for research, the majority of EDs had minimal research output.
Enabling a green just-in-time navigation through stakeholder collaboration
Authors: Arjona Aroca Jordi , Giménez Maldonado José Andrés , Ferrús Clari Gabriel , Alonso i García Nuria , Calabria Lucía , Lara Jorge 
Published: April 2020

Abstract
Background
The shipping industry has grown spectacularly during the last 50 years transporting nowadays, approximately, the 80–90% of goods worldwide. However, maritime transport remains a highly inefficient industry. Only in the last 10–15 years has the industry started studying how to optimize navigation speeds and digitization is just entering ports. Consequently, institutions like the International Maritime Organization (IMO) are pressing towards the adoption of measures that increase the industry efficiency, like Just-In-Time (JIT) operations.

Methods and Results
This paper shows why the Sea Traffic Management (STM) concept, based on stakeholder collaboration, is a JIT enabler. To do so, we analyze 1 year of navigation data of 33 ships, estimating the impact of JIT barriers on shipping and showing the benefits that the adoption of STM, with different maturity levels, could provide to the industry. Our evaluation shows that, only for containerships, STM can help reducing by 15–23% of fuel consumption and GHG emissions.
Origin-dependence of variation in seed morphology, mineral composition and germination percentage in Gynandropsis gynandra (L.) Briq. accessions from Africa and Asia
Authors: Blalogoe Jelila S. , Odindo Alfred O. , Sogbohossou E. O. Dêêdi , Sibiya Julia , Achigan-Dako Enoch G. 
Published: April 2020

AbstractBackgroundSpider plant [Gynandropsis gynandra(L.) Briq.], an economically promising African leafy vegetable, characterized for leaf yield components and nutritive quality, exhibits poor seed germination that hinders a wider expansion of the crop in urban and periurban horticultural systems. So far, there is little information pertaining to seed morphological traits and mineral elements content that may be associated with higher seed germination. This research investigated the hypothesis that spider plants from different geographical areas exhibited differences in seed mineral composition, morphological traits, and germination capacity. To this end, twenty-nine accessions ofGynandropsis gynandrafrom West and East-Southern Africa, and Asia were screened for variation in seed size (area, perimeter, length, width), 10-seed weight, mean germination time, germination percentage and mineral content variations. The scanning electron microscopy (SEM), light microscopy and energy dispersive spectroscopy (EDS) solution were used to study seed morphology and mineral composition.ResultsWe show for the first time the external and internal structure of the seeds ofGynandropsis gynandraand measured eight mineral elements, including carbon (C), oxygen (O), magnesium (Mg), aluminium (Al), phosphorus (P), sulphur (S), potassium (K) and calcium (Ca). The accessions differed significantly (p < 0.001) with respect to seed size (area, perimeter, length, width), 10-seed weight, mean germination time and germination percentage. The hierarchical cluster analysis based on fourteen variables grouped the accessions into three distinct clusters, partially dependent on their geographical origin. Asian accessions exhibited smaller seeds and recorded higher values in terms of germination percentage. West African accessions had bigger seeds but with lower germination percentage. Variation in minerals such as potassium, carbon, and calcium content showed different patterns according to geographical origins.ConclusionSmaller seeds inG. gynandraexhibited better germination capacity. The Asian germplasm is a potential source of cultivars with a higher germination percentage for improving seed quality in the species.
Congenital chloride diarrhea and Pendred syndrome: case report of siblings with two rare recessive disorders of SLC26 family genes
Authors: Lindberg Eva , Moller Claes , Kere Juha , Wedenoja Satu , Anderzén-Carlsson Agneta 
Published: April 2020

Abstract
Background
Congenital chloride diarrhea (CLD; OMIM 214700) is a rare autosomal recessive disorder caused by pathogenic variations in the solute carrier family 26 member A3 (SLC26A3) gene. Without salt substitution, this chronic diarrheal disorder causes severe dehydration and electrolyte disturbances. Homozygous variants in the nearby gene SLC26A4 disrupt anion exchange in the inner ear and the thyroid, causing Pendred syndrome (PDS; OMIM 274600), which is the most frequent form of syndromic deafness.

Case presentation
We report an unusual co-occurrence of two rare homozygous mutations in both the SLC26A3 and SLC26A4 genes, causing a rare combination of both CLD and PDS in two siblings. Although the clinical pictures were typical, the combined loss of these anion transporters might modulate the risk of renal injury associated with CLD.

Conclusions
Familial presentation of two rare autosomal recessive disorders with loss of function of different SLC26 anion transporters is described. Independent homozygous variants in the SLC26A3 and SLC26A4 genes cause CLD and PDS in siblings, shedding light on co-occurrence of rare recessive traits in the progeny of consanguineous couples.
INHBA is a prognostic predictor for patients with colon adenocarcinoma
Authors: Li Xueying , Yu Weiming , Liang Chao , Xu Yuan , Zhang Miaozun , Ding Xiaoyun , Cai Xianlei 
Published: April 2020

AbstractBackgroundColon adenocarcinoma (COAD) is one of the most lethal cancers. It is particularly important to accurately predict prognosis and to provide individualized treatment. Several lines of evidence suggest that genetic factors and clinicopathological characteristics are related to cancer onset and progression. The aim of this study was to identify potential prognostic genes and to develop a nomogram to predict survival and recurrence of COAD.MethodsTo identify potential prognostic genes in COAD, microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were obtained from GEO2R. Venn diagram was drawn to select those genes that were overexpressed in all datasets, and survival analyses were performed to determine the prognostic values of the selected genes. New nomograms were developed based on the genes that were significantly associated with prognosis. Clinicopathological data were obtained from The Cancer Genome Atlas (TCGA). Finally, the new nomograms were compared head-to-head comparison with the TNM nomogram.ResultsFrom GSE21510, GSE110223, GSE113513 and GSE110224, a total of 834, 218, 236 and 613 overexpressed DEGs were screened out, respectively. The Venn diagram revealed that 12 genes appeared in all four profiles. After survival analyses, only INHBA expression was associated with both overall survival (OS) and disease-free survival (DFS). Multivariate analyses revealed that age, pathological N and pathological M were significant independent risk factors for OS. Age, pathological N, pathological M and INHBA were significant independent risk factors for DFS. Two prediction models predicted the probability of 3-year survival and 5-year survival for OS and DFS, respectively. The concordance indexes were 0.785 for 3-year overall survival, 0.759 for 5-year overall survival, 0.789 for 3-year disease-free survival and 0.757 for 5-year disease-free survival. The head-to-head comparison according to time-dependent ROC curves indicated that the new models had higher predictive accuracy. Decision curve analyses (DCA) indicated that the clinical value of the new models were higher than TNM models for predicting disease-free survival.ConclusionThe combination of INHBA expression with a clinical nomogram improves prognostic power in colon adenocarcinoma, especially for predicting recurrence.
Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
Authors: Yoon Seon-Jin , Park Jungmin , Shin Youngmin , Choi Yuna , Park Sahng Wook , Kang Seok-Gu , Son Hye Young , Huh Yong-Min 
Published: April 2020

Abstract
Background
Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell line can be useful for gastric cancer researchers. In this article, we aimed to characterize the diffuse gastric cancer cells with MRI and transcriptomic data. We hypothesized that gene expression pattern is associated with the phenotype of the cells and that the heterogeneous enhancement pattern and the high tumorigenicity of SNU484 can be modulated by the perturbation of the highly expressed gene.

Methods
We evaluated the 9.4 T magnetic resonance imaging and transcriptomic data of the orthotopic mice models from diffuse gastric cancer cells such as SNU484, Hs746T, SNU668, and KATO III. We included MKN74 as an intestinal cancer control cell. After comprehensive analysis integrating MRI and transcriptomic data, we selected CD34 and validated the effect by shRNA in the BALB/c nude mice models.

Results
SNU484, SNU668, Hs746T, and MKN74 formed orthotopic tumors by the 5 weeks after cell injection. The diffuse phenotype was found in the SNU484 and Hs746T. SNU484 was the only tumor showing the heterogeneous enhancement pattern on T2 images with a high level of CD34 expression. Knockdown of CD34 decreased the round-void shape in the H&E staining (P = 0.028), the heterogeneous T2 enhancement, and orthotopic tumorigenicity (100% vs 66.7%). The RNAseq showed that the suppressed CD34 is associated with the downregulated gene-sets of the extracellular matrix remodeling.

Conclusion
Suppression of CD34 in the human-originated gastric cancer cell suggests that it is important for the round-void histologic shape, heterogeneous enhancement pattern on MRI, and the growth of gastric cancer cell line.
Axial length change and its relationship with baseline choroidal thickness – a five-year longitudinal study in Danish adolescents: the CCC2000 eye study
Authors: Hansen Mathias Hvidtfelt , Kessel Line , Li Xiao Qiang , Skovgaard Anne Mette , Larsen Michael , Munch Inger Christine 
Published: April 2020

Abstract
Background
Myopic eyes are longer than nonmyopic eyes and have thinner choroids. The purpose of present study was to investigate whether a thinner subfoveal choroid at 11 years of age predicted axial eye elongation and myopia during adolescence.

Methods
Longitudinal, population-based observational study. Axial length was measured using an interferometric device and choroidal thickness was measured by spectral-domain optical coherence tomography. Myopia was defined as non-cycloplegic subjective spherical equivalent refraction ≤ − 0.50 diopters.

Results
Right eyes of 714 children (317 boys) were examined at age (median (IQR)) 11.5 (0.6) years and 16.6 (0.3) years during which axial length (median (IQR)) increased by 243 (202) μm in eyes without myopia (n = 630) at baseline compared with 454 (549) μm in eyes with myopia (n = 84) at baseline, p < 0.0001. A thicker baseline subfoveal choroid was associated with increased five-year axial elongation after adjustment for baseline axial length in nonmyopic eyes (β = 27 μm/100 μm, 95%CI 6 to 48, p = 0.011) but not in myopic eyes (p = 0.34). Subfoveal choroidal thickness at 11 years of age did not predict incident myopia at 16 years of age (p = 0.11). Longer baseline axial length was associated with greater five-year axial elongation in both myopic (β = 196 μm/mm, 95%CI 127 to 265, p < 0.0001) and nonmyopic eyes (β = 28 μm/mm, 95%CI 7 to 49, p = 0.0085) and the odds for incident myopia increased with 1.57 (95%CI 1.18 to 2.09, p = 0.0020) per mm longer axial length at baseline.

Conclusion
A thin subfoveal choroid at age 11 years did not predict axial eye elongation and incident myopia from age 11 to 16 years. A longer eye at age 11 years was associated with greater subsequent axial eye elongation and with increased risk of incident myopia at age 16 years.
Comparison of facilitated tucking and oral dextrose in reducing the pain of heel stick in preterm infants: a randomized clinical trial
Authors: Ranjbar Athareh , Bernstein Colleen , Shariat Mamak , Ranjbar Hadi 
Published: April 2020

Abstract
Background
With the increase in hospitalization of premature infants in emergency departments and the painful procedure in these sectors, appropriate methods of pain relief are required. This study aimed to compare the effect of oral dextrose and facilitated tucking in the reduction of pain during heel sticks in premature infants and assess their effectiveness and feasibility for use in emergency settings.

Methods
This study was a randomized controlled clinical trial with cross-over design. Sixty infants were recruited from a Neonatal Intensive Care Unit (NICU) at Valiasr hospital in Tehran, Iran from March 2015 to September 2016. They were randomly allocated into three groups (no pain relief method, oral dextrose and facilitated tucking). Six blood samples were collected by heel stick for each infant. Oral dextrose and facilitated tucking were compared with the routine method of blood sampling and pain was measured two times for each method. The pain scores was measured by the Premature Infant Pain Profile (PIPP). Repeated Measure ANOVA, ANOVA and Scheffe post-hoc test were used with SPSS 16.

Results
The pain score’s increase during heel stick was significantly lower after using oral dextrose (3.58 ± 0.34) and facilitated tucking (5.58 ± 0.53) in comparison to the routine method (8.91 ± 0.18) of blood sampling (P < 0.001, η2 = 0.971). Oral dextrose was more effective than facilitated tucking (P < 0.001, Cohen’s d = 4.49). The emergency nurses rated oral dextrose as easier (t = 2.20, df = 118, p = 0.02, Cohen’s d = 0.39) and more applicable method (t = 2.99, df = 118, p = 0.003, Cohen’s d = 0.54) for the emergency department.

Conclusions
Facilitated tucking is an effective method of pain reduction which can be used in the absence of oral dextrose, in a situation in which it is contraindicated or in combination with oral dextrose. Based on the increase of infant’s admission in emergency department future studies are needed to identify the best method of pain reduction for procedures in this setting.

Trial registration
Current Controlled Trials IRCT201408029568N9, 2014-09-08.