bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cycloid psychosis as a psychiatric expression of anti‐NMDAR encephalitis. A systematic review of case reports accomplished with the authors' cooperation
Authors: Giné Servén Eloi , Boix Quintana Ester , Martínez Ramírez Maria , Guanyabens Buscà Nicolau , Muriana Batiste Desiree , Guasp Mar , Torres Rivas Cristina , Davi Loscos Eva , Casado Ruiz Virginia 
Published: December 2020

AbstractObjectiveWe reviewed the psychotic symptoms of anti‐NMDA receptor encephalitis (NMDARE) to differentiate its presentation from those found in a primary psychiatric disorder. We hypothesized that the cycloid psychosis (CP) phenotype would be a frequent clinical presentation in the psychiatric phase of NMDARE.MethodA systematic literature review in PubMed of all case reports published on NMDARE was performed from database inception to March 2020. We included all cases where psychotic symptoms were reported and whose diagnoses were confirmed by the presence of anti‐NMDAR antibodies in the cerebrospinal fluid (CSF). An email including a short test (CP phenotype, Perris and Brockington's criteria) was sent to all case report authors asking them to describe the psychotic symptoms.ResultsWe identified 335 case reports fulfilling our criteria, and the authors of 200 replied. Our analyses were based exclusively on those answers and data extracted from the articles. Median patient age was 25 years (+‐11.4), 81% were female, and 39% had an ovarian teratoma. A complete CP phenotype was identified in 175 patients (87%). These were acute psychotic episodes with a sudden onset and a fluctuating clinical pattern mostly characterized by confusion (97%), delusions (75%), hallucinations (69%), motility disturbances (87%), and mood oscillations (80%).ConclusionThe complete CP phenotype was frequently the expression of psychotic symptoms in NMDARE. We suggest that patients with a first psychotic episode who initially exhibit the CP phenotype should undergo CSF analysis to determine whether antibodies against neuronal cell surface or synaptic receptors are present to rule out a possible diagnosis of autoimmune encephalitis.
Development and validation of a web‐based calculator to predict individualized conditional risk of site‐specific recurrence in nasopharyngeal carcinoma: Analysis of 10,058 endemic cases
Authors: Wu Chen‐Fei , Lv Jia‐Wei , Lin Li , Mao Yan‐Ping , Deng Bin , Zheng Wei‐Hong , Wen Dan‐Wan , Chen Yue , Kou Jia , Chen Fo‐Ping , Yang Xing‐Li , Zheng Zi‐Qi , Li Zhi‐Xuan , Xu Si‐Si , Ma Jun , Sun Ying 
Published: December 2020

AbstractBackgroundConditional survival (CS) provides dynamic prognostic estimates by considering the patients existing survival time. Since CS for endemic nasopharyngeal carcinoma (NPC) is lacking, we aimed to assess the CS of endemic NPC and establish a web‐based calculator to predict individualized, conditional site‐specific recurrence risk.MethodsUsing an NPC‐specific database with a big‐data intelligence platform, 10,058 endemic patients with non‐metastatic stage I–IVA NPC receiving intensity‐modulated radiotherapy with or without chemotherapy between April 2009 and December 2015 were investigated. Crude CS estimates of conditional overall survival (COS), conditional disease‐free survival (CDFS), conditional locoregional relapse‐free survival (CLRRFS), conditional distant metastasis‐free survival (CDMFS), and conditional NPC‐specific survival (CNPC‐SS) were calculated. Covariate‐adjusted CS estimates were generated using inverse probability weighting. A prediction model was established using competing risk models and was externally validated with an independent, non‐metastatic stage I–IVA NPC cohort undergoing intensity‐modulated radiotherapy with or without chemotherapy (n = 601) at another institution.ResultsThe median follow‐up of the primary cohort was 67.2 months. The 5‐year COS, CDFS, CLRRFS, CDMFS, and CNPC‐SS increased from 86.2%, 78.1%, 89.8%, 87.3%, and 87.6% at diagnosis to 87.3%, 87.7%, 94.4%, 96.0%, and 90.1%, respectively, for an existing survival time of 3 years since diagnosis. Differences in CS estimates between prognostic factor subgroups of each endpoint were noticeable at diagnosis but diminished with time, whereas an ever‐increasing disparity in CS between different age subgroups was observed over time. Notably, the prognoses of patients that were poor at diagnosis improved greatly as patients survived longer. For individualized CS predictions, we developed a web‐based model to estimate the conditional risk of local (C‐index, 0.656), regional (0.667), bone (0.742), lung (0.681), and liver (0.711) recurrence, which significantly outperformed the current staging system (P < 0.001). The performance of this web‐based model was further validated using an external validation cohort (median follow‐up, 61.3 months), with C‐indices of 0.672, 0.736, 0.754, 0.663, and 0.721, respectively.ConclusionsWe characterized the CS of endemic NPC in the largest cohort to date. Moreover, we established a web‐based calculator to predict the CS of site‐specific recurrence, which may help to tailor individualized, risk‐based, time‐adapted follow‐up strategies.
Imaging and 2‐year clinical outcomes of thin strut sirolimus‐eluting bioresorbable vascular scaffold: The MeRes‐1 extend trial
Authors: Abizaid Alexandre , Kedev Sasko , Ali Rosli Bin Mohd , Santoso Teguh , Cequier Angel , van Geuns Robert‐Jan Van Geuns , Chevalier Bernard , Hellig Farrel , Costa Ricardo , Onuma Yoshinobu , Costa Jose Ribamar , Serruys Patrick , Bangalore Sripal 
Published: December 2020

AbstractObjectivesThis study explores the safety and efficacy of thin strut MeRes100 sirolimus‐eluting bioresorbable vascular scaffold (BRS) in patients with de novo coronary artery lesions.BackgroundIn interventional cardiology, the emergence of BRS technology is catalyzing the next paradigm shift.MethodsThe MeRes‐1 Extend was a multicenter, prospective, single‐arm, open‐label study enrolling 64 patients in Spain, Macedonia, Brazil, South Africa, Malaysia, and Indonesia. The safety endpoint was major adverse cardiac events (MACE) which composed of cardiac death, myocardial infarction (MI), and ischemia‐driven target lesion revascularization (ID‐TLR). The imaging efficacy endpoint was mean in‐scaffold late lumen loss (LLL) evaluated by quantitative coronary angiography (QCA). Optical coherence tomography (OCT) imaging was performed at baseline and 6‐month follow‐up.ResultsA total of 69 target lesions were identified in 64 enrolled patients (mean age 58.30 ± 9.02 years). Of the treated lesions, 49 (71.01%) lesions were of type B2/C. Procedural and device success was achieved in 64 and 62 patients, respectively. At 2‐year follow‐up, MACE was reported in one patient (1.61%) in the form of ID‐TLR. There was no case of MI, cardiac death or scaffold thrombosis through 2‐year. In a subset of 32 patients, paired QCA showed mean in‐scaffold LLL of 0.18 ± 0.31 mm at 6‐month follow‐up. In a subset of 21 patients, OCT revealed 97.95 ± 3.69% strut coverage with mean scaffold area of 7.56 ± 1.79 mm2 and no evidence of strut malapposition.ConclusionsThe clinical and imaging outcomes of MeRes‐1 Extend trial demonstrated favorable safety and efficacy of MeRes100 sirolimus‐eluting BRS in patients with de novo coronary artery lesions.
Postemergence smooth crabgrass control is not influenced by herbicide combinations with trinexapac‐ethyl
Authors: Bearss Ryan C. , Patton Aaron J. , Brosnan James T. , Breeden Gregory K. 
Published: December 2020

Core Ideas
Trinexapac‐ethyl (TE) is a common plant growth regulator used in turfgrass systems.

The effects of TE on herbicide efficacy to control smooth crabgrass were unknown.

Mixing TE with postemergence herbicides did not affect smooth crabgrass control.
Keramische Membrantechnologie für die Verfügbarmachung biogener Stoffströme
Authors: Ebrahimi Mehrdad , Humpert Daniel , Schönherr Stefan , Czermak Peter 
Published: December 2020

AbstractIm Rahmen dieser Forschungsarbeit wurde ein effizientes membranbasiertes Verfahren zur Rückgewinnung von gereinigtem Ligninsulfonat (LS) aus der Dünnlauge des chemischen Holzaufschlusses mithilfe von keramischen Ultrafiltrationsmembranen entwickelt. Das Ziel dabei war, die Ligninsulfonate von niedermolekularen organischen Verunreinigungen (Zucker, Carbonsäuren etc.) und Prozesschemikalien abzutrennen, sie aufzukonzentrieren und sie für eine gezielte Weiterverwertung bereitzustellen. Ein weiterer Aspekt des Projektes war die Separation der Produkte (Zielmoleküle) der Lignosulfonatspaltung mittels keramischer Membrantechnologie.
Droplet Size Distributions of Liquid‐Liquid Dispersions in Centrifugal Pumps
Authors: Schmitt Philipp , Sibirtsev Stephan , Hlawitschka Mark W. , Styn Robert , Jupke Andreas , Bart Hans‐Jörg 
Published: December 2020

AbstractThe generation of liquid‐liquid dispersions with defined droplet size distributions is an important aspect for process equipment design. In this work, two centrifugal pumps with different impeller diameters were used to generate dispersions at selected operating points for a paraffin oil‐water system. The droplet break‐up phenomena within the centrifugal pumps were analyzed using a transparent pump design in combination with high‐speed imaging. Droplet size distributions at centrifugal pump discharge nozzle were recorded with optical probe measurement technologies and evaluated by means of image processing using a neural network. The influence of impeller diameter, rotational speed, volumetric flow rate and dispersed phase fraction are discussed. Experimental data is correlated using fluid properties, operating data as well as centrifugal pump dimensions. The correlations developed from results of this work serve as a basis for the equipment design of centrifugal pumps.
Full‐field PIV/DIA and local concentration measurements of ozone decomposition in riser‐flow
Authors: Carlos Varas Alvaro E. , Peters E. A. J. F. , Kuipers J. A. M. 
Published: December 2020

AbstractA full‐field PIV‐DIA technique has been coupled to concentration measurements in order to characterize the riser performance at different gas superficial velocities and reaction rates for ozone decomposition. Experiments under riser flow conditions were performed with the use of a compact pseudo‐2D lab‐scale riser reactor. The purpose of this work is to generate reliable experimental data to validate computational models for mass transfer in riser flow conditions. The catalytic activity of the particles was characterized. To analyze the reaction rate effect over the performance of a riser reactor, two catalyst batches with different activities were used and their kinetics were measured. The hydrodynamics of the gas‐solid flow was determined using the PIV‐DIA technique. Particle clusters were identified and characterized. By correlating the cluster information and mass concentration measurements, it was shown that a higher frequency of local flow heterogeneities near the walls led to higher conversion rates than in the core of the riser. Reaction rate and gas superficial effects are analyzed.
Mass transfer around a compound drop in an extensional flow
Authors: Favelukis Moshe 
Published: December 2020

AbstractMass transfer around a spherical compound drop in an extensional creeping flow and at large Peclet numbers is theoretically studied. The compound drop, embedded in an external fluid (fluid 1), is composed from a spherical inner drop (fluid 3), which is engulfed by a spherical fluid shell (fluid 2). The study is governed by four dimensionless parameters: two viscosity ratios, shell over external fluid (λ21) and internal drop over shell (λ32); the radii ratio, inner over outer (κ); and the large Peclet number (Pe). For very fast mobile interfaces, the rate of mass transfer is proportional to Pe1/2, it increases as λ21 or κ decrease, and in the limit of a very small internal drop (κ → 0) it reduces to the case of a single drop. For very slow mobile interfaces or immobile interfaces, the rate of mass transfer is proportional to Pe1/3, it increases as λ21 or κ increase, and in the limit of a very thin shell (κ → 1) it behaves like a single solid particle. For both interface speed cases, the effect of the other viscosity ratio (λ32) on the external mass transfer is practically negligible.
Blood‐based biomarkers of human papillomavirus–associated cancers: A systematic review and meta‐analysis
Authors: Balachandra Sanjana , Kusin Samuel B. , Lee Rebecca , Blackwell James‐Michael , Tiro Jasmin A. , Cowell Lindsay G. , Chiang Cheng‐Ming , Wu Shwu‐Yuan , Varma Sanskriti , Rivera Erika L. , Mayo Helen G. , Ding Lianghao , Sumer Baran D. , Lea Jayanthi S. , Bagrodia Aditya , Farkas Linda M. , Wang Richard , Fakhry Carole , Dahlstrom Kristina R. , Sturgis Erich M. , Day Andrew T. 
Published: December 2020

BackgroundDespite the significant societal burden of human papillomavirus (HPV)–associated cancers, clinical screening interventions for HPV‐associated noncervical cancers are not available. Blood‐based biomarkers may help close this gap in care.MethodsFive databases were searched, 5687 articles were identified, and 3631 unique candidate titles and abstracts were independently reviewed by 2 authors; 702 articles underwent a full‐text review. Eligibility criteria included the assessment of a blood‐based biomarker within a cohort or case‐control study.ResultsOne hundred thirty‐seven studies were included. Among all biomarkers assessed, HPV‐16 E seropositivity and circulating HPV DNA were most significantly correlated with HPV‐associated cancers in comparison with cancer‐free controls. In most scenarios, HPV‐16 E6 seropositivity varied nonsignificantly according to tumor type, specimen collection timing, and anatomic site (crude odds ratio [cOR] for p16+ or HPV+ oropharyngeal cancer [OPC], 133.10; 95% confidence interval [CI], 59.40‐298.21; cOR for HPV‐unspecified OPC, 25.41; 95% CI, 8.71‐74.06; cOR for prediagnostic HPV‐unspecified OPC, 59.00; 95% CI, 15.39‐226.25; cOR for HPV‐unspecified cervical cancer, 12.05; 95% CI, 3.23‐44.97; cOR for HPV‐unspecified anal cancer, 73.60; 95% CI, 19.68‐275.33; cOR for HPV‐unspecified penile cancer, 16.25; 95% CI, 2.83‐93.48). Circulating HPV‐16 DNA was a valid biomarker for cervical cancer (cOR, 15.72; 95% CI, 3.41‐72.57). In 3 cervical cancer case‐control studies, cases exhibited unique microRNA expression profiles in comparison with controls. Other assessed biomarker candidates were not valid.ConclusionsHPV‐16 E6 antibodies and circulating HPV‐16 DNA are the most robustly analyzed and most promising blood‐based biomarkers for HPV‐associated cancers to date. Comparative validity analyses are warranted. Variations in tumor type–specific, high‐risk HPV DNA prevalence according to anatomic site and world region highlight the need for biomarkers targeting more high‐risk HPV types. Further investigation of blood‐based microRNA expression profiling appears indicated.
What do these sounds tell us about the therapeutic alliance: Acoustic markers as predictors of alliance
Authors: Nof Aviv , Amir Ofer , Goldstein Pavel , Zilcha‐Mano Sigal 
Published: December 2020

Predicting the trajectories of alliance formation that the patient is likely to establish with the therapist during treatment, even before their first meeting, can help prevent the potentially harmful consequences of deterioration in alliance, such as poor outcome and premature dropout. The present study aimed to examine the ability of four pretreatment acoustic markers to predict the alliance that is likely to be formed in the course of treatment: F0 span, speech rate, pause proportion and jitter. Data from 560 observations of 38 patients were collected as part of an ongoing randomized clinical trial of short‐term psychotherapy for major depressive disorder. The acoustic markers were measured using high‐quality recordings at baseline, before the patient and therapist ever met or had any type of communication. A multilevel model was used to examine the ability of the four acoustic markers to predict the slopes of alliance formation in the course of treatment, all markers being introduced in the same model. The clinical utility of the acoustic markers was explored in two case studies. The model explained 22% of the variance in alliance formation. Higher levels of both jitter and pause proportion at baseline predicted less strengthening of the alliance in the course of treatment. The findings, which should be replicated in larger samples, suggest that much of the therapeutic alliance can be predicted based on the acoustic characteristics of the patient's voice in the first 3 min of their intake, before they even meet their therapist.
How does greenwashing influence managers' decision‐making? An experimental approach under stakeholder view
Authors: Ferrón‐Vílchez Vera , Valero‐Gil Jesus , Suárez‐Perales Inés 
Published: December 2020

AbstractGreenwashing is a communication practice that consists of the deliberate and voluntary disclosure of environmentally misleading (or even false) information by a firm and which the public understands to be deceptive. Although prior literature analyzes greenwashing effects from the greenwasher perspective, the underlying perceptions of managers in the decision‐making process related to maintaining (or contracting a new) a commercial partner, client, supplier, or other stakeholder who is a greenwasher, remain underexplored. This work empirically examines how greenwashing could influence managers' decision‐making and whether a moderation effect of attitude toward environmental management exists in this relationship. In doing so, this work relies on experimental design.
Vehicle video surveillance system based on image fusion and parallel computing
Authors: Liu Shan , Lyu Chengang , Gong Haotian 
Published: December 2020

SummaryAutonomous driving has gradually moved towards practical applications in recent years. It is particularly critical to provide reliable real‐time environmental information for autonomous driving systems. At present, vehicle video surveillance systems based on multi‐source video and target detection algorithms can effectively solve these problems. However, the previous vehicle video surveillance systems are often unable to balance the surveillance effect and the surveillance frame rate. Therefore, we will introduce a vehicle video surveillance system based on parallel computing and computer vision in this article. First, multiple fisheye cameras are used to collect surround‐view environmental information. Second, we will use a low‐light camera, infrared thermal imager, and millimeter‐wave radar to provide forward‐view environmental information at night. Correspondingly, we designed the surround‐view image fusion algorithm and the forward‐view image fusion algorithm based on parallel computing. At last, a monocular camera and detection algorithms are used to provide forward‐view detection results. In a word, this vehicle video surveillance system will benefit the practical application of autonomous driving.
An optimized SDS‐PAGE protocol with a new blotting system for the initial testing procedure of ESAs in doping control
Authors: Martin Laurent , Martin Jean‐Antoine , Audran Michel , Marchand Alexandre 
Published: December 2020

AbstractRecombinant erythropoietins (rEPOs) are still among the substances endurance athletes use for doping. Detection methods are based on an electrophoretic separation of the proteins followed by a western blot and immunodetection with specific anti‐EPO antibodies. In addition to IEF‐PAGE, the SDS‐PAGE method has been used to differentiate endogenous EPO from rEPOs by their molecular weight (MW). However, to adapt to new generations of rEPOs exhibiting higher MW, which were not well detected after SDS‐PAGE, sodium lauroyl sarcosinate (SAR) is now used instead of sodium dodecyl sulfate (SDS) for the initial EPO testing procedure on doping control samples. The SAR‐PAGE method is nevertheless expensive as it requires frequent buffer preparations using highly purified sarkosyl powder. In addition, this reagent needs to be handled with care due to acute toxicity by inhalation. The aim of this work was to improve the SDS‐PAGE method by increasing its sensitivity and transfer of high‐MW rEPOs. First, using a biotinylated primary anti‐EPO antibody and avoiding the use of a secondary antibody increased the general sensitivity of both SDS‐PAGE and SAR‐PAGE to all rEPOs about four‐fold. Then, by changing the buffer system during the protein transfer, with a CAPS buffer and a discontinuous buffer transfer system, high‐MW rEPOs, EPO‐Fc and CERA were transferred with higher efficiency and detected with high sensitivity. This optimized SDS‐PAGE protocol could be adopted by anti‐doping laboratories as an alternative to SAR‐PAGE.
Spatial capture–recapture with multiple noninvasive marks: An application to camera‐trapping data of the European wildcat (Felis silvestris) using R package multimark
Authors: Maronde Lea , McClintock Brett T. , Breitenmoser Urs , Zimmermann Fridolin 
Published: December 2020

AbstractIn Switzerland, the European wildcat (Felis silvestris), a native felid, is protected by national law. In recent decades, the wildcat has slowly returned to much of its original range and may have even expanded into new areas that were not known to be occupied before. For the implementation of efficient conservation actions, reliable information about the status and trend of population size and density is crucial. But so far, only one reliable estimate of density in Switzerland was produced in the northern Swiss Jura Mountains. Wildcats are relatively rare and elusive, but camera trapping has proven to be an effective method for monitoring felids. We developed and tested a monitoring protocol using camera trapping in the northern Jura Mountains (cantons of Bern and Jura) in an area of 100 km2. During 60 days, we obtained 105 pictures of phenotypical wildcats of which 98 were suitable for individual identification. We identified 13 individuals from both sides and, additionally, 5 single right‐sided flanks and 3 single left‐sided flanks that could not be matched to unique individuals. We analyzed the camera‐trap data using the R package multimark, which has been extended to include a novel spatial capture–recapture model for encounter histories that include multiple “noninvasive” marks, such as bilaterally asymmetrical left‐ and right‐sided flanks, that can be difficult (or impossible) to reliably match to individuals. Here, we present this model in detail for the first time. Based on a “semi‐complete” data likelihood, the model is less computationally demanding than Bayesian alternatives that rely on a data‐augmented complete data likelihood. The spatially explicit capture–recapture model estimated a wildcat density (95% credible interval) of 26 (17–36) per 100 km2 suitable habitat. Our integrated model produced higher abundance and density estimates with improved precision compared to single‐sided analyses, suggesting spatially explicit capture–recapture methods with multiple “noninvasive” marks can improve our ability to monitor wildcat population status.