bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear shear analysis of I-shaped beams with arbitrary inclination angles of shear reinforcement
Authors: Pochinok Vladimir , Tamov Murat , Greshkina Ekaterina 
Published: July 2020

Abstract
We studied the effect of the inclination angle of stirrups and wire mesh on the web-crushing strength of reinforced concrete I-beams beams. Experimental studies were carried out in Kuban State Technological University. The variable parameters of the tested specimens included concrete compressive strength, level of prestressing, cross-sectional shape, shear span, shear reinforcement ratio and angles of inclination of stirrups or wire mesh. The strength of beams was calculated with the Cyclic Softened Membrane Model for reinforced concrete (CSMM), developed at the University of Houston and implemented in the OpenSees software package. The modeling of the web of the beams was fulfilled with quadrilateral finite elements with the assigned material FAReinforcedConcretePlaneStress. The flanges of the beams resisting the bending moment were modeled with nonlinear volumetric elements having fiber section. Uniaxial Kent-Scott-Park concrete material and uniaxial bilinear steel material were assigned to the flanges. Calculation results are close to experimental data having wide variation of the materials properties and structural parameters of beams.
The design of the overall stability of the Shukhov radio tower taking into account the local damage
Authors: Mamin Aleksandr , Kodysh Emil , Bobrov Vladimir , Reutsu Aleksandr , Klovsky Aleksej 
Published: July 2020

Abstract
The construction of the radio tower engineer V. Shukhov. For almost one hundred years the structures and components of the radio tower are heavily corroded which resulted in local damage. The danger of accumulation and increase of local damage is that they lead to the collapse of the tower. In 2016 anti-damage support structure was made to exclude the sudden avalanche-like collapse of the structure of the radio tower engineer V. Shukhov (Fig. 1). But there is a risk of formation and distribution of local damage. The checking calculation of the Shukhov radio tower was performed to identify the impact of the anti-damage support structure, taking into account the local damage. The calculation was made at the software complex “Lira-CAD”. Normative loads, their application, reliability coefficients for loads and combination coefficients are adopted in accordance with Building Act 20.13330.2016 “Loads and impacts”. The compatibility of the Shukhov radio tower and the anti-damage support structure is provided by pre-tension in the suspensions units of the radio tower attached to the support structure consoles. The tension force was determined by the calculation based on the experimental results of 2015.
The results of the combined geometrically nonlinear analysis of the Shukhov radio tower and the support structures showed the increased overall stability of the radio tower; the maximum movement of the unit stands and support rings was reduced by 20-30%, the maximum stands stress were reduced by 10-15% due to the load redistribution among the stands, but the maximum stress slightly exceed the allowed value. The complex of checking calculations of the Shukhov radio tower and the supporting structures showed that the existing anti-damage construction eliminates a sudden avalanche-like collapse of the structure. There is a risk of formation and distribution of local damage with the irreversible deformations of the stands and support rings of the radio tower with the increase of defects and damages of the structure of the radio tower which are still in a damage state. For a more uniform distribution of loads and increase the overall stability of the structure, it is necessary to increase the number of consoles of anti-damage support structure to 24 at each level of the support structure. Full-scale restoration works of the Shukhov radio tower structures are required to prevent the formation and distribution of local damages.
Review and analysis of winter concreting methods, used on construction sites in Russia
Authors: Zhuravlyov E G 
Published: July 2020

AbstractThe features of the application of winter concreting methods on construction sites in Russia are considered: thermos methods (thermos, hot thermos), progressive methods (electrode heating, induction heating, infrared heating, the heating of the heating wires, heated in the mold thermoactive or thermoactive a flexible covering, heating in enclosures), concreting with antifreeze additives. The analysis of the application of winter concreting methods on construction sites in Eastern Siberia is carried out.
Some aspects of risk management in the investment and construction sector
Authors: Khokhlova G I , Yushina J A , Burov V Y 
Published: July 2020

Abstract
Risk is an important factor that results from the execution of any economic decision and occurs in the conditions of uncertainty and cyclical development inherent in a market economy. Classification and assessment of risks specific to construction organizations is a complex and strategic task based on the application of various models, taking into account the industry’s risk management features. The purpose of this work is to study the methodological and practical aspects of risk assessment for making management decisions in the investment and construction sector. The study focuses on such interrelated concepts as “uncertainty” and “risk” and their impact on business performance in the market conditions. The authors prove that the risks typical for the construction industry in Russia have their own specific features and depend on such significant factors as the level of taxes, the volume of orders, the cost of materials and structures, the availability of sufficient financial resources, and the payment capabilities of customers. Depending on the categories of construction companies, the most significant risks are identified (technological, commercial, investment and innovation risks). The authors studied the essence and features of risk assessment taking into account international standards and practical aspects in the investment and construction complex. The scientific article reveals the role of risk management in risk management in the investment and construction sector, the main problems of using methods to minimize risks for various categories of construction organizations in Russian practice.
Compensation Measurement Study for Aspherical Primary Mirror of Space Camera with CGH
Authors: Liu Xiaolei , Sun Xiaofeng , Dong Xiaomeng , Yang Dong 
Published: July 2020

Abstract
With the development of modern optical technology, demands on the performance of optical systems are increasing. Aspherical surfaces are widely used in space optical system considering its excellent ability in correcting aberrations, reducing the optical system weight and simplifying the optical construction. However, the interferometry of this kind of aspherical surface is difficult. To overcome the difficulty in testing aspherical primary mirror of space camera system, we provide a compensation method to accomplish the null testing of the aspherical primary mirror with CGH (Computer generated hologram). Our proposed method is introduced in detail in the theory part. In addition, we provide a detailed design for an actual parabolic surface. The results show that our proposed method can accomplish the testing of aspherical primary mirror in large aperture with satisfactory accuracy.
Finite Element Analysis of Antenna Array of Large Meter Wave Height Mobile Dual Polarization Radar based on NASTRAN
Authors: Wei Wang Jin , Qing Gu Ye , Fu Tang Bao 
Published: July 2020

Abstract
A large-scale meter wave high maneuvering dual polarization radar is designed with a cantilever folded beam. In order to realize the high tolerance spread of its dual polarization antenna, it is necessary to ensure that its folded spread antenna array has high plane stiffness. Firstly, the finite element model is established according to the geometrical model of the antenna array. Secondly, the corresponding load conditions are determined according to the material parameters of the antenna array, different wind loads and temperature fields. Then, the mechanical calculation and analysis of the antenna array are carried out by using NASTRAN software, and the deformation, stress and deformation of the antenna array element and folded beam under different conditions are obtained Square root value. The results show that the array can meet the requirements of stiffness and strength.
Surface potential measurement by heterodyne frequency modulation Kelvin probe force microscopy in MHz range
Authors: Sugawara Yasuhiro , Miyazaki Masato , Li Yan Jun 
Published: July 2020

Abstract
The chemical and physical processes on surfaces are significantly influenced by the surface potential of materials. When using the frequency modulation Kelvin probe force microscopy (FM-KPFM), which has been widely used for measuring the surface potential distribution with high spatial resolution, it is very difficult to distinguish the surface potential due to the surface state from that due to the bulk state, because the charge transfer between the surface and bulk states occurs at a low-frequency ac bias voltage in the kHz range. Here, we propose a heterodyne FM-KPFM method using a high-frequency ac bias voltage in the MHz range to distinguish the surface and bulk states. This method is based on the heterodyne effect between the mechanical cantilever oscillation and the oscillating electrostatic force. For the first time, we succeeded in achieving the atomic-resolution imaging of the surface potential on an O-rich TiO2(110) surface using the electrostatic interaction in the MHz range. Furthermore, we could measure the upward and downward band bending on the surface at the atomic scale.
TALC: Transcript-level Aware Long-read Correction
Authors: Broseus Lucile , Thomas Aubin , Oldfield Andrew J , Severac Dany , Dubois Emeric , Ritchie William 
Published: July 2020

Abstract

Motivation
Long-read sequencing technologies are invaluable for determining complex RNA transcript architectures but are error-prone. Numerous ‘hybrid correction’ algorithms have been developed for genomic data that correct long reads by exploiting the accuracy and depth of short reads sequenced from the same sample. These algorithms are not suited for correcting more complex transcriptome sequencing data.

Results
We have created a novel reference-free algorithm called Transcript-level Aware Long-Read Correction (TALC) which models changes in RNA expression and isoform representation in a weighted De Bruijn graph to correct long reads from transcriptome studies. We show that transcript-level aware correction by TALC improves the accuracy of the whole spectrum of downstream RNA-seq applications and is thus necessary for transcriptome analyses that use long read technology.

Availability and implementation
TALC is implemented in C++ and available at https://github.com/lbroseus/TALC.

Supplementary information
Supplementary data are available at Bioinformatics online.
BYASE: a Python library for estimating gene and isoform level allele-specific expression
Authors: Dong Lili , Wang Jianan , Wang Guohua 
Published: July 2020

Abstract

Summary
Allele-specific expression (ASE) is involved in many important biological mechanisms. We present a python package BYASE and its graphical user interface (GUI) tool BYASE-GUI for the identification of ASE from single-end and paired-end RNA-seq data based on Bayesian inference, which can simultaneously report differences in gene-level and isoform-level expression. BYASE uses both phased SNPs and non-phased SNPs, and supports polyploid organisms.

Availability and implementation
The source codes of BYASE and BYASE-GUI are freely available at https://github.com/ncjllld/byase and https://github.com/ncjllld/byase_gui.

Supplementary information
Supplementary data are available at Bioinformatics online.
A sparse additive model for treatment effect-modifier selection
Authors: Park Hyung , Petkova Eva , Tarpey Thaddeus , Ogden R Todd 
Published: July 2020

Summary
Sparse additive modeling is a class of effective methods for performing high-dimensional nonparametric regression. This article develops a sparse additive model focused on estimation of treatment effect modification with simultaneous treatment effect-modifier selection. We propose a version of the sparse additive model uniquely constrained to estimate the interaction effects between treatment and pretreatment covariates, while leaving the main effects of the pretreatment covariates unspecified. The proposed regression model can effectively identify treatment effect-modifiers that exhibit possibly nonlinear interactions with the treatment variable that are relevant for making optimal treatment decisions. A set of simulation experiments and an application to a dataset from a randomized clinical trial are presented to demonstrate the method.
Bioanalysis and Quadrupole-Time of Flight-Mass Spectrometry Driven In Vitro Metabolite Profiling of a New Boronic Acid-Based Anticancer Molecule
Authors: Zagade Aarati Dilip , Shard Amit , Shinde Shital , Sahu Amit Kumar , Sengupta Pinaki 
Published: July 2020

Abstract
(E/Z)-(4-(3-(2-((4-chlorophenyl)amino)-4-(dimethylamino)thiazol-5-yl)-2-(ethoxy carbonyl)-3-oxoprop-1-en-1-yl)phenyl) boronic acid, a newly developed molecule having anticancer activity serves as a potential candidate for the further drug development process. In this study, to ascertain the anticancer potential of the molecule, we screened it against different cell lines and compared the activity against the standard drug doxorubicin. The molecule showed promising activity at a low concentration against almost all cell lines used in the study. Apart from that, the molecule was characterized for its pKa and a precise reverse phase high-performance liquid chromatography bioanalytical method has been developed. The method was validated according to the United States of Food and Drug Administration bioanalytical guideline and was found to produce linear response over the calibration range of 0.8–25 μg/mL. Inter- and intra-day accuracy were found to be in the range of 93.44–99.74%, whereas precision [% coefficient of variation (CV)] for inter- and intra-day was ranged between 1.63 and 5.79%, and 0.87 and 6.96%, respectively. The bioanalytical stability testing was carried out in different conditions including 8 h benchtop, 12 h autosampler and three freeze–thaw cycles. The analyte was stable in all the tested stability conditions. Finally, an in vitro metabolite identification study was conducted using quadrupole-time of flight-mass spectrometer, and two metabolites have been identified.
Application of Optimized and Validated Agar Overlay TLC–Bioautography Assay for Detecting the Antimicrobial Metabolites of Pharmaceutical Interest
Authors: Nuthan Bettadapura Rameshgowda , Rakshith Devaraju , Marulasiddaswamy Kuppuru Mallikarjunaiah , Rao H C Yashavantha , Ramesha Kolathur Puttamadaiah , Mohana Nagabhushana Chandra , Siddappa Shiva , Darshan Doreraj , Kumara Kigga Kaadappa Sampath , Satish Sreedharamurthy 
Published: July 2020

Abstract
The agar overlay TLC–bioautography is one of the crucial methods for simultaneous in situ detection and separation of antimicrobial metabolites of pharmaceutical interest. The main focus of this research relies on the dereplication of an antimicrobial metabolite coriloxin derived from mycoendophytic Xylaria sp. NBRTSB-20 with a validation of agar overlay TLC–bioautography technique. This polyketide metabolite coriloxin was purified by column chromatography, and its purity was assessed by HPLC, UPLC-ESI-QTOF-MS, FT-IR and NMR spectral analysis. The antimicrobial capability of ethyl acetate extract and the purified compound coriloxin was determined by disc diffusion, minimal inhibitory concentration and agar overlay TLC–bioautography assay. The visible LOD of coriloxin antimicrobial activity was found at 10 μg for Escherichia coli and 20 μg for both Staphylococcus aureus and Fusarium oxysporum. Inter- and intra-day precision was determined as the relative standard deviation is less than 6.56%, which proved that this method was precise. The accuracy was expressed as recovery, and the values were found ranging from 91.18 to 108.73% with RSD values 0.94–2.30%, respectively. The overall findings of this investigation suggest that agar overlay TLC–bioautography assay is a suitable and acceptable method for the in situ determination of antimicrobial pharmaceuticals.
Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation
Authors: Toor Jaspreet , Adams Emily R , Aliee Maryam , Amoah Benjamin , Anderson Roy M , Ayabina Diepreye , Bailey Robin , Basáñez Maria-Gloria , Blok David J , Blumberg Seth , Borlase Anna , Rivera Rocio Caja , Castaño María Soledad , Chitnis Nakul , Coffeng Luc E , Crump Ronald E , Das Aatreyee , Davis Christopher N , Davis Emma L , Deiner Michael S , Diggle Peter J , Fronterre Claudio , Giardina Federica , Giorgi Emanuele , Graham Matthew , Hamley Jonathan I D , Huang Ching-I , Kura Klodeta , Lietman Thomas M , Lucas Tim C D , Malizia Veronica , Medley Graham F , Meeyai Aronrag , Michael Edwin , Porco Travis C , Prada Joaquin M , Rock Kat S , Le Rutte Epke A , Smith Morgan E , Spencer Simon E F , Stolk Wilma A , Touloupou Panayiota , Vasconcelos Andreia , Vegvari Carolin , de Vlas Sake J , Walker Martin , Hollingsworth T Déirdre 
Published: July 2020

AbstractDue to the COVID-19 pandemic, many key neglected tropical disease (NTD) activities have been postponed. This hindrance comes at a time when the NTDs are progressing towards their ambitious goals for 2030. Mathematical modelling on several NTDs, namely gambiense sleeping sickness, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases (STH), trachoma, and visceral leishmaniasis, shows that the impact of this disruption will vary across the diseases. Programs face a risk of resurgence, which will be fastest in high-transmission areas. Furthermore, of the mass drug administration diseases, schistosomiasis, STH, and trachoma are likely to encounter faster resurgence. The case-finding diseases (gambiense sleeping sickness and visceral leishmaniasis) are likely to have fewer cases being detected but may face an increasing underlying rate of new infections. However, once programs are able to resume, there are ways to mitigate the impact and accelerate progress towards the 2030 goals.
Efficacy and Safety of Albendazole in Hookworm-infected Preschool-aged Children, School-aged Children, and Adults in Côte d’Ivoire: A Phase 2 Randomized, Controlled Dose-finding Trial
Authors: Patel Chandni , Coulibaly Jean T , Hofmann Daniela , N’Gbesso Yves , Hattendorf Jan , Keiser Jennifer 
Published: July 2020

Abstract

Background
Infections with hookworms affect about half a billion people worldwide. Recommended therapy includes 400 mg of albendazole, which is moderately efficacious. Higher doses have been rarely assessed.

Methods
A randomized, controlled dose-finding trial was conducted in Côte d’Ivoire with the aim of recruiting 120 preschool-aged children (PSAC), 200 school-aged children (SAC), and 200 adults. Eligible PSAC were randomized 1:1:1 to 200 mg, 400 mg, or 600 mg of albendazole; the other age groups were randomized 1:1:1:1:1 to placebo or 200 mg, 400 mg, 600 mg, or 800 mg. The primary outcome was cure rates (CRs) assessed 14–21 days post-treatment by quadruplicate Kato-Katz thick smears. Hyperbolic Emax models were used to determine dose-response.

Results
38 PSAC, 133 SAC, and 196 adults were enrolled. In adults, predicted CRs increased with ascending doses of albendazole, with a CR of 74.9% (95% confidence interval [CI], 55.6%–87.7%) in the 800-mg arm. Observed CRs increased with ascending doses of albendazole reaching a maximum of 94.1% (95% CI, 80.3%–99.3%). In SAC, the predicted dose-response curve increased marginally, with CRs ranging from 64.0% in the 200-mg arm to 76.0% in the 800-mg arm. Sample size in PSAC was considered too small to derive meaningful conclusions. 10.7% and 5.1% of participants reported any adverse event at 3 hours and 24 hours post-treatment, respectively.

Conclusions
A single 800-mg albendazole dose provides higher efficacy against hookworm and is well tolerated in adults and should be considered for community-based strategies targeting adults. For PSAC and SAC, current recommendations suffice.

Clinical Trials Registration
NCT03527745.
Long-term Outcome of Short-course High-dose Glucocorticoids for Severe Acute Respiratory Syndrome (SARS): A 17-Year Follow-up in SARS Survivors
Authors: Sing Chor-Wing , Tan Kathryn C B , Wong Ian C K , Cheung Bernard M Y , Cheung Ching-Lung 
Published: July 2020

Abstract
Use of high-dose glucocorticoids for COVID-19 (caused by SARS-CoV-2) is controversial because of safety concerns. We examined the long-term consequences of glucocorticoid use in severe acute respiratory syndrome (caused by SARS-CoV-1) survivors. Results showed that high-dose glucocorticoids greatly increased the long-term risk of avascular necrosis but not other major diseases.
Allied Decoupling in an Era of US–China Strategic Competition
Authors: Cha Victor D 
Published: July 2020

Abstract
The turn towards an openly competitive relationship between the United States and China today carries acute consequences for U.S. policy toward North Korea (Democratic People’s Republic of Korea or DPRK) and South Korea (Republic of Korea or ROK). The military and economic requirements of enacting such a policy of competition with China complicates U.S. policy with its ally South Korea, as it exacerbates three core dilemmas that the ROK contends with regarding China. These dilemmas compel choices for a U.S. ally that must increasingly become zero-sum in nature where Seoul must make choices that alienate its patron ally or its neighbor. This article draws out propositions for how changes in U.S.-China relations impacts strategy on both sides of the Korean peninsula. The primary finding is that changes in the independent variable (U.S.-China relations) have opposing impacts on South Korean and North Korean strategic thinking (dependent variable). What might be considered opportunities afforded by U.S.-China relations to South Korea are seen as threats by North Korea. Conversely opportunities created by U.S.-China relations for North Korea register as threats for South Korea.
Gut microbiome of the emerald ash borer, Agrilus planipennis Fairmaire, and its relationship with insect population density
Authors: Mogouong Judith , Constant Philippe , Lavallée Robert , Guertin Claude 
Published: July 2020

ABSTRACT
The gut microbial communities of beetles play crucial roles in their adaptive capacities. Environmental factors such as temperature or nutrition naturally affect the insect microbiome, but a shift in local conditions like the population density on a host tree could also lead to changes in the microbiota. The emerald ash borer (EAB), Agrilus planipennis Fairmaire, is an exotic wood borer that causes environmental and economic damage to ash trees in North America. This study aimed to describe the taxonomic structure of the EAB gut microbiome and explore its potential relationship with borer population size. The number of EAB adults collected per tree through a 75 km transect from an epicenter allowed the creation of distinct classes of population density. The Gammaproteobacteria and Ascomycota predominated in bacterial and fungal communities respectively, as determined by sequencing of the bacterial 16S rRNA gene and the fungal internal transcribed spacer ITS2. Species richness and diversity of the bacterial community showed significant dependence on population density. Moreover, α-diversity and β-diversity analysis revealed some indicator amplicon sequence variants suggesting that the plasticity of the gut microbiome could be related to the EAB population density in host trees.