bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of appropriateness of hospitalisations in Ukraine: analytical framework, method and findings
Authors: Zhao Feng , Doroshenko Olena , Lekhan Valery N , Kriachkova Lilia V , Goroshko Alona 
Published: December 2019

ObjectivesThis article reviews the applicability of a customised version of the Appropriateness Evaluation Protocol (AEP) to evaluate the magnitude of inappropriate hospitalisations in two regions of Ukraine.Data and methodsThe original AEP was modified to develop a customised tool, which included criteria for the appropriateness of hospitalisation and duration of inpatient stay. The customisation of the tool followed the Delphi procedure. We randomly selected 381 medical records to test the feasibility and reliability of the method and 800 medical records to evaluate the scope of inappropriate hospitalisations. We used descriptive and analytical statistics, receiver operating characteristic curve analysis and Cohen's kappa to check the consistency between the findings of primary reviewers and experts.ResultWe observed high levels of agreement in conclusions of primary reviewers (reference standard) and experts during testing of the reliability and validity of the method. The external validity check showed that the use of the tool by different experts provided high accuracy: 95.1 sensitivity, 76.6 specificity and area under ROC-curve (AUC)=0.948 (р<0.001) for analysis of the appropriateness of admissions; 95.3 sensitivity, 84.7 specificity and AUC=0.900 (р=0.001) for the duration of hospitalisations. Cohen's kappa coefficient (κ) indicated agreement in expert evaluations of 0.915 (95% СІ 0.799 to 1.000) and 0.812 (95% СІ 0.749 to 0.875), respectively.We found that over one-third of admissions (38.1%; 95% СІ 33.9 to 43.5) and over half of total bed-days were unnecessary (57.4%; 95% СІ 56.4 to 58.5). The highest levels of stay were observed in hospitals’ general medicine departments (64.6%; 95% СІ 63.0 to 66.3)compared with other departments included in the analysis.ConclusionThe proposed method is robust in assessing the appropriateness of hospitalisations and duration of inpatient stays. The quantified levels of unnecessary hospital care indicate the need for improving efficiency and quality of care and optimising the excessive hospital capacities in Ukraine.
Healthcare providers’ perception of the referral system in maternal care facilities in Aceh, Indonesia: a cross-sectional study
Authors: Diba Farah , Ichsan Ichsan , Muhsin Muhsin , Marthoenis Marthoenis , Sofyan Hizir , Andalas Mohammad , Monfared Ida , Richert Katharina , Kaplan Lennart , Rogge Lisa , Doria Siobhan , Samadi Samadi , Vollmer Sebastian 
Published: December 2019

ObjectivesOur study investigates the barriers perceived by staff in the referral systems in maternal healthcare facilities across Aceh province in Indonesia.DesignWith a cross-sectional approach, two sets of surveys were administered during September to October 2016 in 32 sampling units of our study. We also collected referral data in the form of the frequency of ingoing and outgoing referral cases per facility.SettingIn three districts, Aceh Besar, Banda Aceh and Bireuen, a total of 32 facilities including hospitals, community health centres, and private midwife clinics that met the criteria of providing at least basic emergency obstetric and neonatal care (BEonC) were covered.ParticipantsAcross the 32 healthcare centres, 149 members of staff (mainly midwives) agreed to participate in our surveys.Primary and secondary outcome measuresThe first survey consisted of 65 items focusing on organisational measures as well as case numbers for example, patient counts, mortality rate and complications. The second survey with 68 items asked healthcare providers about a range of factors including attitudes towards the referral process in their facility and potential barriers to a well-functioning system in their district.ResultsOverall, mothers’/families’ consent as well as the complex administration process were found to be the main barriers (36% and 12%, respectively). Healthcare providers noted that information about other facilities has the biggest room for improvement (37%) rather than transport, timely referral of mothers and babies, or the availability of referral facilities.ConclusionsThe largest barrier perceived by healthcare providers in our study was noted to be family consent and administrative burden. Moreover, lack of information about the referral system itself and other facilities seemed to be affecting healthcare providers and mothers/families alike and improvements perhaps through a shared information system is needed.
Internal consistency and reliability of the Swiss-French translation of the venous leg ulcer self efficacy tool (VeLUSET)
Authors: Probst Sebastian , Turcotte Mathieu , Buehrer Skinner Monika 
Published: December 2019

ObjectiveThis study was conducted to assess the psychometric properties of the translated and adapted Venous Leg Ulcer Self Efficacy Tool (VeLUSET) in the new cultural context.DesignValidation studySettingThree outpatient clinics in Western Switzerland.Participants32 consecutive persons with venous leg ulcers (VLU).Main outcome measuresTo determine the internal consistency and reliability of the VeLUSET for use in a Swiss-French speaking venous leg ulcer population.ResultsOverall, the Cronbach alpha for the VeLUSET-FR was 0.96 (95% CI 0.93 to 0.98) on test and retest. Lin’s concordance correlation coefficient of test and retest scores was 0.93 (95% CI 0.86 to 0.96).ConclusionThe results indicate that the VeLUSET-FR is a valid and reliable instrument for measuring self-efficacy among Swiss-French persons affected by a venous leg ulcer. Our findings show that the psychometric properties are similar to those of the original tool. Therefore, we suggest that the VeLUSET-FR can be effectively used for measuring self-efficacy in Swiss-French persons with VLU.
Diagnostic accuracy of E-cadherin for malignanteffusions: a systematic review and meta-analysis
Authors: Chen Fangying , Dai Luqi , An Jing , Zeng Ni , Chen Lei , Shen Yongchun 
Published: December 2019

AbstractBackgroundThe differential diagnosis of malignant effusion remains a clinical challenge. We aim to summarise all relevant literature studies in order to determine the overall clinical value of E-cadherin in the diagnosis of malignant effusion by meta-analysis.MethodsPubMed, the Cochrane Library Database, Medline (Ovid), Web of Science, CNKI, WANFANG and WEIPU databases are thoroughly searched up to 15 March2018. The calculated pooled sensitivity, specificity, likelihood ratio (LR), diagnostic OR(DOR) and the summary receiver operating characteristic (SROC) curve were plotted.ResultsA total of 15 studies were included in the analysis. The sensitivity and specificity of E-cadherin in the diagnosis of malignant effusion were determined to be high, with a sensitivity of 0.83(95%CI0.79 to 0.87) and a specificity of 0.96(95%CI0.90 to 0.98). The positive LR was determined to be 21.10(95%CI 8.54 to 52.11), the negative LR was determined to be 0.17(95% CI 0.14 to 0.22) and the DOR was determined to be 121.34(95%CI 49.11 to 299.80). The SROC curve exhibited a high overall diagnostic, with the area under the curve measured to be 0.91(95% CI 0.89 to 0.93). Subgroup analysis showed the method (cell blocks or smears), sample size (≥100 or&lt;100), geographical location (Asia, Europe or USA) and impact factor of each article (≥3 or&lt;3) were not the sources of overall heterogeneity.ConclusionE-cadherin exhibits very good diagnostic accuracy for the diagnosis for malignant effusion; thus, it can be helpful in the process of clinical decisions.
Reduction of multiple scattering of high-energy positively charged particles during channeling in single crystals
Authors: Scandale W. , Esposito L. S. , Garattini M. , Rossi R. , Zhovkovska V. , Natochii A. , Addesa F. , Iacoangeli F. , Galluccio F. , Murtas F. , Afonin A. G. , Chesnokov Yu. A. , Durum A. A. , Maisheev V. A. , Sandomirskiy Yu. E. , Yanovich A. A. , Smirnov G. I. , Gavrikov Yu. A. , Ivanov Yu. M. , Koznov M. A. , Malkov M. V. , Malyarenko L. G. , Mamunct I. G. , Borg J. , James T. , Hall G. , Pesaresi M. 
Published: December 2019

AbstractWe present the experimental observation of the reduction of multiple scattering of high-energy positively charged particles during channeling in single crystals. According to our measurements the rms angle of multiple scattering in the plane orthogonal to the plane of the channeling is less than half that for non-channeled particles moving in the same crystal. In the experiment we use focusing bent single crystals. Such crystals have a variable thickness in the direction of beam propagation. This allows us to measure rms angles of scattering as a function of thickness for channeled and non-channeled particles. The behaviour with thickness of non-channeled particles is in agreement with expectations whereas the behaviour of channeled particles has unexpected features.
Contributions from $${\Phi }_{B2}$$ to the B $${\rightarrow }$$ PP decays within the QCD factorization
Authors: Chang Qin , Chen Lili , Zhang Yunyun , Sun Junfeng , Yang Yueling 
Published: December 2019

AbstractWith the potential for the improvements of measurement precision, the refinement of theoretical calculation on hadronic B weak decays is necessary. In this paper, we study the contributions of B mesonic distribution amplitude $${\Phi }_{B2}$$ΦB2 within the QCD factorization approach, and find that $${\Phi }_{B2}$$ΦB2 contributes to only the nonfactorizable annihilation amplitudes for the B$${\rightarrow }$$→PP decays (P denotes the ground SU(3) pseudoscalar mesons). Although small, the $${\Phi }_{B2}$$ΦB2 contributions might be helpful for improving the performance of the QCD factorization approach, especially for the pure annihilation $$B_{d}$$Bd$${\rightarrow }$$→$$K^{+}K^{-}$$K+K- and $$B_{s}$$Bs$${\rightarrow }$$→$${\pi }^{+}{\pi }^{-}$$π+π- decays.
Combination of Erlotinib and Naproxen Employing Pulsatile or Intermittent Dosing Profoundly Inhibits Urinary Bladder Cancers
Authors: Mohammed Altaf , Miller Mark Steven , Lubet Ronald A. , Suen Chen S. , Sei Shizuko , Shoemaker Robert H. , Juliana Margaret M. , Moeinpour Fariba L. , Grubbs Clinton J. 
Published: December 2019

AbstractDaily dosing of either NSAIDs or EGFR inhibitors has been shown to prevent bladder cancer development in a N-butyl-(4-hydroxybutyl)nitrosamine (OH-BBN)-induced rat model. However, these inhibitors cause gastrointestinal ulceration and acneiform rash, respectively, limiting their continuous use in a clinical prevention setting. We studied chemopreventive efficacy of pulsatile dosing of EGFR inhibitor erlotinib (42 mg/kg BW, once/week) combined with intermittent or continuous low doses of the NSAID naproxen (30 mg/kg BW/day, 3 weeks on/off or 128 ppm daily in diet) in the OH-BBN induced rat bladder cancer model. The interventions were started either at 1 or 4 weeks (early intervention) or 3 months (delayed intervention) after the last OH-BBN treatment, by which time the rats had developed microscopic bladder lesions. All combination regimens tested as early versus late intervention led to the reduction of the average bladder tumor weights (54%–82%; P &lt; 0.01 to P &lt; 0.0001), a decrease in tumor multiplicity (65%–85%; P &lt; 0.01 to P &lt; 0.0001), and a decrease in the number of rats with large palpable tumors (&gt;200 mg; 83%–90%; P &lt; 0.01 to P &lt; 0.0001). Levels of signal transduction markers, Ki-67, cyclin D1, IL1β, pSTAT3, and pERK, were significantly (P &lt; 0.05 to P &lt; 0.001) reduced in the treated tumors, demonstrating their potential utility as predictive markers for efficacy. These findings demonstrate that significant chemopreventive efficacy could be achieved with alternative intervention regimens designed to reduce the toxicity of agents, and that starting erlotinib and/or naproxen treatments at the time microscopic tumors were present still conferred the efficacy.
Impact of Aortomitral Continuity Calcification on Need for Permanent Pacemaker After Transcatheter Aortic Valve Replacement
Authors: Katchi Farhan , Bhatt Deep , Markowitz Steven M. , Szymonifka Jackie , Cheng Edward P. , Minutello Robert M. , Bergman Geoffrey W. , Wong S. Chiu , Salemi Arash , Truong Quynh A. 
Published: December 2019

Background:
By virtue of its proximity to structures vital to cardiac conduction, aortomitral continuity calcification (AMCC) may help identify patients at highest risk for developing atrioventricular conduction disease requiring permanent pacemaker implantation (PPMI). We aim to determine the association of AMCC and need for PPMI after transcatheter aortic valve replacement.

Methods:
Of 614 patients who underwent transcatheter aortic valve replacement (11.8% PPMI rate), we included 136 patients (age 85±8 years, 47% male) without a preexisting intracardiac device or prior valve surgery who underwent preprocedural computed tomography. We analyzed for the presence of AMCC, aortic valve calcification, and mitral annular calcification as well as quantified AMCC and aortic valve calcification score using the Agatston method. We further stratified AMCC score into 3 categories: 0, 1 to 300, and >300. End point was PPMI at 1 month after transcatheter aortic valve replacement.

Results:

There were 51 (38%) new PPMIs (median time to PPMI, 5 days). Patients who underwent PPMI had a higher prevalence of AMCC than patients without PPMI (69% versus 32%;
P
<0.0001), as well as higher median AMCC score (263 versus 0;
P
<0.0001). There was no difference in aortic valve calcification and mitral annular calcification between patients with and without PPMI (all
P
≥0.09). Patients with AMCC had a 4-fold increase in odds for PPMI compared with those without (adjusted odds ratio, 4.0;
P
=0.0026). Compared with patients with an AMCC score of 0, patients with an AMCC score >300 had greater than a 5-fold increased odds for PPMI (adjusted odds ratio, 5.7;
P
=0.0016).

Conclusions:
Presence of AMCC, particularly with AMCC score >300, is associated with the need for PPMI after transcatheter aortic valve replacement.
<p><strong>Seed Shape Diversity in families of the Order Ranunculales</strong></p>
Authors: MARTÍN-GÓMEZ JOSÈ JAVIER , REWICZ AGNIESZKA , CERVANTES EMILIO 
Published: December 2019

Seed shape in the order Ranunculales is described with the objective of characterizing the morphological seed types in the families of this order and to establish a correlation between seed shape, plant structure and life style. Based on previous work in model plants (Arabidopsis thaliana, Lotus japonicus, Medicago truncatula), we have used the J index to estimate the percentage of similarity of the image of a seed with a geometric shape. The images of seeds of model plants resemble cardioid or cardioid-derived models, while seeds from other species with rapid life cycles resemble other, also simple geometrical figures. In general, seed shape may help establishing the relationships between taxonomic groups. Three types of seed morphology are distinguished in the Ranunculales based on values of J index. In the first type, seeds in the Berberidaceae, Euptelaceae and Lardizabalaceae, adjust well to an oval. The second type, seeds in the Papaveraceae, adjust well to the cardioid model, and the third type, seeds in the Ranunculaceae, adjust well to diverse geometric shapes, including the oval, truncated cardioid, Fibonacci spiral and ellipse. In the Ranunculales, seed shape is varied and often related to geometrical figures. The presence of cardioid derived models in the Papaveraceae supports our hypothesis that seeds resembling the cardioid are frequent in plants with rapid life cycles.Ranunculales
Periclimenella agattii sp. nov., a new Palaemonid shrimp (Crustacea, Decapoda, Palaemonidae) from Lakshadweep Islands, India
Authors: BHARATHI S. , PURUSHOTHAMAN P. , AKASH S. , JOSE SHEENA , MADHAVAN MANU , DHINAKARAN A. , SARAVANANE N. , KUMAR T.T. AJITH , LAL KULDEEP KUMAR 
Published: December 2019

The recent collection of Palaemonid shrimps from Agatti Island, Lakshadweep, Arabian Sea, have provided further additions to the Indian marine fauna. In the manuscript, a new species, Periclimenella agattii sp. nov. is described and illustrated. The new species is morphologically most similar to P. spinifera among other congeners, but it strongly differs from that species by having upper the antennular flagellum with 14–16 segments, short free ramus with 12–13 segments, lower antennal flagellum thin and bearing 35–37 segments; 4 minute lateral spines on basal segment of 3rd maxilliped; male palm:carpus ratio of second pereopod higher than in female, propodus of 3rd pereopod with 7–8 ventral spines and hepatic spine with groove. Genetic analysis using the mitochondrial COI and 16S rRNA genes sequences proved that, the new species is significantly distinct from the closed related species.
High-Resolution Temperature Mapping by Geostatistical Kriging with External Drift from Large-Eddy Simulations
Authors: Varentsov Mikhail , Esau Igor , Wolf Tobias 
Published: December 2019

Abstract
Detailed temperature maps are required in various applications. Any temperature interpolation over complex terrain must account for differences in land cover and elevation. Local circulations and other small-scale factors can also perturb the temperature. This study considers the surface air temperature T mapping with geostatistical kriging. The kriging methods are implemented for both T and temperature anomalies ΔT, defined as difference between T at a given location and T at the same elevation in the free atmosphere. The study explores the parallelized atmospheric large-eddy simulation (LES) model (PALM) as a source for variogram and external drift in the kriging methods. Ten kriging methods for the temperature mapping have been considered: ordinary kriging (OK) of T and ΔT with variogram derived from the observations (methods 1 and 2, correspondingly); OK of T and ΔT with variogram derived from LES data (3 and 4); universal kriging with external drift (KED) that utilizes the LES data (5 and 6); a weighted combination of KED of T and ΔT (method 7); and methods 5, 6, and 7 enhanced with additional “virtual” points in remote areas (methods 8, 9, and 10). These 10 methods are evaluated for eight typical weather situations observed in Bergen, Norway. Our results demonstrate considerable added value of the LES information for the detailed meteorological temperature mapping. The LES data improve both the variogram and the resulting temperature maps, especially in the remote mountain parts of the domain and along the coast.
Occupational Repertoire Development Measure – Parent (ORDM-P): Face validity, comprehensiveness, and internal consistency
Authors: Njelesani Janet , Davis Jane A , Pontes Tatiana 
Published: December 2019

Introduction An occupational repertoire is the array of occupations that an individual has the perceived capacity to perform at a specific point in time. The Occupational Repertoire Development Measure – Parent is a new tool that uses parent report to identify the occupations children can and do perform and their interests in and opportunities for doing them. This study aimed to test the face validity, comprehensiveness, and internal consistency of the Occupational Repertoire Development Measure – Parent as a tool to measure the occupational repertoire of children aged between 2 and 12 years. Method Twenty-nine occupational therapists completed an online questionnaire about the Occupational Repertoire Development Measure – Parent, and 27 parents completed it and then provided feedback via a structured interview. Descriptive statistics, content analysis, and the content validity index guided data analysis. Results Participants view the Occupational Repertoire Development Measure – Parent as practical, simple, and supportive of occupation-centred practice to optimize children’s development of a meaningful repertoire. Overall, self-care occupations were rated highly relevant. Lower-scoring occupations were those perceived as performed only by older children, nonessential for children with disabilities, or culturally unimportant. Conclusion Results indicate value in the further development of the Occupational Repertoire Development Measure – Parent and validate that it asks relevant questions to understand a child’s performance, engagement, and opportunities, leading to optimal repertoire development.
Housing Choice as a Function of Risks Confronting Low-income Households
Authors: Sahasranaman Anand , Prasad Vishnu , Balachander Aditi 
Published: December 2019

The design of housing solutions for low-income populations has been one of the most pressing policy concerns in developing countries like India. In this work, we explore the effect of risks confronting low-income households—unemployment, health and mortality—on their choice of housing arrangements. We use simulations to study the evolution of long-term wealth of a stylised low-income household faced with these risks and find that, on average, rental housing significantly reduces the risk of undesirable wealth fluctuations over time. From a policy perspective, this means greater focus and incentives for the development of low-income rental markets using strategies such as provision of rental vouchers, rent-to-own models or long-term leases, in addition to the traditional ownership-based housing strategies. The development of housing solutions encompassing a range of rental and ownership models will be critical to ensuring the availability of safe and affordable housing for all urban residents. JEL Codes: C63, O18
Tranexamic acid use in high-risk blood transfusion patients undergoing total hip replacement: a randomised controlled trial
Authors: Kimura Osamu S , Freitas Emílio HCA , Duarte Maria EL , Cavalcanti Amanda S , Fernandes Marco BC 
Published: December 2019

Introduction: We hypothesised that a single preoperative intravenous dose of tranexamic acid (TXA) is effective in patients who undergo total hip arthroplasty (THA) and are at high risk of blood transfusion (preoperative haemoglobin level <13.0 g/dL). Methods: A prospective, randomised controlled study of 308 patients who underwent primary THA was conducted. 256 participants remained in the study and were divided into 2 major groups: high-risk group comprising 116 patients with preoperative Hb < 13.0 g/dL (57 of whom were treated with a 15 mg/kg intravenous bolus of TXA, and 59 of whom did not receive the medication) and low-risk group comprising 140 patients with Hb ⩾ 13.0 g/dL (71 of whom received the same dose of TXA, and 69 of whom did not). Participants were followed up at 3 weeks, 3 months, 6 months, and 1 year after surgery. Results: The use of TXA in both groups of patients significantly increased the levels of postoperative Hb and Ht. TXA protected high-risk patients from blood loss and from transfusion. In low-risk patients the use of TXA reduced blood loss but did not protect from blood transfusion. The median length of stay was significantly affected for high-risk patients. No thromboembolic event was recorded in either group. Conclusions: TXA reduces intra- and postoperative bleeding, transfusion rates, and the length of hospital stays in patients with low preoperative Hb. The use of TXA in patients with normal preoperative Hb reduces blood loss but does not affect the transfusion rate. ClinicalTrials.gov Identifier: NCT03019198