bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEKTIVITAS SENYAWA NONATSIRI DARI Curcuma spp. TERHADAP PENEKANAN PENYAKIT ANTRAKNOSA PADA BUAH CABAI
Authors: Sari Anella Retna Kumala , Rahmah Firdaus Auliya , Djauhari Syamsuddin 
Published: June 2020

<em></em><em>One of the important diseases on chili is anthracnose caused by </em>Colletotrichum capsici<em>. </em>Curcuma<em> extracts and </em><em>their essential oils were known as antifungal, but nonessential compounds have not been widely tested. This study aimed to assay the effectiveness of nonessential compounds of </em>Curcuma longa<em>, </em>C. zedoaria<em>, and </em>C. aeruginosa<em> to </em>C. annuum<em>. This study was conducted in November 2014 until Mei 2015 at Brawijaya University. The nonessential compound was obtained by soaking rhizome of </em>C. longa, C. zedoaria<em>, and </em>C. aeruginosa<em> in methanol, then distilled by</em><em>using rotary vacuum evaporator. Nonessential chemical compunds were identified by using HPLC. Effectiveness evaluation of nonessential compounds from three species of </em>Curcuma<em> was done by in </em>vitro<em> and </em>in vivo<em> test. Tested treatments were three species of </em>Curcuma<em> spp and 6 concentration levels of nonessential compounds (0 ppm, 4 ppm, 6 ppm, 8 ppm, 10 ppm, and</em><em> 12 ppm). The xperiment was performed in Factorial Complete Randomized Design, with 18 treatments combination, and replicated three times. Results of HPLC analysis showed the rhizomes of the three </em>Curcuma<em> species contained curcumin and </em>desmethoxycurcumin<em> in various concentrations. The highest </em><em>level was found in the </em>C. longa<em> extract (13.792 ppm curcumin and 67.156 ppm </em>desmethoxycurcumin<em>). However, in vitro test results showed nonessential compound of </em>C. zedoaria<em> was most effective in inhibiting </em>C. annuum<em> growth. The 10 ppm concentration inhibited 81.53 % of fungal growth. Further, the in vivo test, also indicated the same, it’s most effective in hampering the growth of anthracnose symptoms. Therefore, curcumin and </em>desmethoxycurcumin<em> from three species of </em>Curcuma<em> have potential to be developed as botanical fungicide.</em>
High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique
Authors: Estaleva Calvina E. L. , Zimba Tomas F. , Sekyere John Osei , Govinden Usha , Chenia Hafizah Y. , Simonsen Gunnar S. , Haldorsen Bjørg , Essack Sabiha Y. , Sundsfjord Arnfinn 
Published: June 2020

Abstract
Background: Epidemiological data of cephalosporin-resistant Enterobacterales in Sub-Saharan Africa is still restricted, and in particular in Mozambique. The aim of this study was to detect and characterize extended-spectrum β-lactamase (ESBL) - and plasmid-mediated AmpC (pAmpC)-producing clinical strains of Escherichia coli at Maputo Central Hospital (MCH), a 1,000-bed reference hospital in Maputo, Mozambique.Methods: A total of 230 clinical isolates of E. coli from urine (n=199) and blood cultures (n=31) were collected at MCH during August-November 2015. Antimicrobial susceptibility testing was performed by the disc diffusion method and interpreted according to EUCAST guidelines. Isolates with reduced susceptibility to 3rd generation cephalosporins were examined further; phenotypically for an ESBL-/AmpC-phenotype by combined disc methods and genetically for ESBL- and pAmpC-encoding genes by PCR and partial amplicon sequencing as well as genetic relatedness by ERIC-PCR. Results: A total of 75 isolates with reduced susceptibility to cefotaxime and/or ceftazidime (n=75) from urine (n=58/199; 29%) and blood (n=17/31; 55%) were detected. All 75 isolates were phenotypically ESBL-positive and 25/75 (33%) of those also expressed an AmpC-phenotype. ESBL-PCR and amplicon sequencing revealed a majority of blaCTX-M (n=58/75; 77%) dominated by blaCTX-M-15. All AmpC-phenotype positive isolates (n=25/75; 33 %) scored positive for one or more pAmpC-genes dominated by blaMOX/FOX. Multidrug resistance (resistance ≥ three antibiotic classes) was observed in all the 75 ESBL-positive isolates dominated by resistance to trimethoprim-sulfamethoxazole, ciprofloxacin and gentamicin. ERIC-PCR revealed genetic diversity among strains with minor clusters indicating intra-hospital spread. Conclusion: We have observed a high prevalence of MDR pAmpC- and/or ESBL-producing clinical E. coli isolates with FOX/MOX and CTX-Ms as the major β-lactamase types, respectively. ERIC-PCR analyses revealed genetic diversity and some clusters indicating within-hospital spread. The overall findings strongly support the urgent need for accurate and rapid diagnostic services to guide antibiotic treatment and improved infection control measures.
Spatial distribution and determinant factors of Female Genital Mutilation among reproductive age women in Ethiopia, 2016; Based on Ethiopian National Demographic and Health Survey
Authors: Muluneh Atalay Goshu , Kassa Getahun Molla , Merid Mehari WoldeMariam 
Published: June 2020

Abstract
Background: Though condemned and considered as a crime by the countries government, Female Genital Mutilation (FGM) remains a common public health problem in Africa and Ethiopia as well. Every year, more than 3 million females undergo FGM and most of them are in Africa. Thus, this study was aimed to assess the spatial distribution and associated factors of female genital mutilation in Ethiopia based on the Ethiopian demographic and Health Survey 2016 data. Method: This is a secondary data analysis of Ethiopian Demographic and Health Survey (EDHS) 2016 data based on 7,163 women who were included for the FGM interview. The data were weighted using sampling weight as recommended by the program. The MS Excel and ArcGIS 10.3 software were used for data cleaning and spatial analysis respectively. Global and local level clustering was assessed. For the none spatial data and the determinant factors, data cleaning and analysis were done using STATA 14. Since the data has significant clustering with the Intraclass Correlation Coefficient [ICC=0.61(0.56, 0.65)], a multi-level mixed-effect logistic regression model was fitted. Variables with a P-value <0.25 in the bi-variable analysis were fitted in the multi-variable analysis. Finally, variables with p-value <0.05 with 95% CI of adjusted odds ratio were reported as a statistically significant determinant of FGM. Result: Female genital mutilation was spatially clustered (Global Moran’s I: 0.48, p<0.001). Significant hot spot clusters were found in Eastern-Amhara, Oromia, Southern Nations Nationalities and Peoples (SNNP) regions, Dire-Dawa, and Harari. Mothers age >30 (AOR=2.41, 95% CI: 1.78,3.26) years, never in union (AOR=0.31, 95%CI: 0.22, 0.44), currently not working (AOR=0.71, 95%CI: 0.55, 0.92), women who considered FGM to be continued (AOR=2.86, 95%CI: 1.75, 4.68), not heard of FGM (AOR=0.22, 95%CI: 0.08,0.62), had no formal education (AOR=1.67, 95% CI: 1.03, 2.71), Muslim (AOR=3.90, 95%CI:2.5, 6.09) and protestant (AOR=1.76, 95%CI: 1.25, 2.97), and those who thought of FGM required by religion (AOR=1.99, 95%CI: 1.31,2.99) were found to be significant determinants of female genital mutilation.Conclusion: Female genital mutilation was spatially clustered with hotspot areas found:in Eastern-Amhara, Oromia, and SNNP regions, Dire-Dawa and Harari administrative. Age of the mother, religion, occupation, educational level, marital status, information about Female genital mutilation, and intention about FGM to be stopped or continued were significant determinants of female genital mutilation
Socioeconomic status, social capital, health risk behaviors, and health-related quality of life among Chinese older adults
Authors: Yang Ying , Wang Shizhen , Chen Lei , Luo Mi , Xue Lina , Cui Dan , Mao Zongfu 
Published: June 2020

Abstract
Background: There is limited knowledge on the mediating role of different health risk behavior on the relationship between social capital, socioeconomic status (SES), and health-related quality of life (HRQoL) in Chinese older adults. We conducted this study to (a) investigate the condition of health risk behaviors of the Chinese elderly, and (b) assess the relationship between SES, social capital, health risk behaviors, and HRQoL. Methods: A sample of 4,868 adults aged 60 years and older were included in this study, from the China's Health-related Quality of Life Survey for Older Adults 2018. Participants' demographic characteristics, SES (education level, family income), health risk behaviors (smoking, alcohol consumption, physical inactivity, unhealthy dietary behavior, unhealthy weight, and sleep disorder) were collected. Social capital and HRQoL were assessed by the 16-item Personal Social Capital Scale (PSCS-16) and WHOQOL-Old, respectively. Structural equation modeling (SEM) was applied to examine the associations between variables. Results: The proportion of smoking, alcohol consumption, physical inactivity, unhealthy dietary behavior, unhealthy weight, and sleep disorder were 32.1%, 36.3%, 62.5%, 45.7%, 31.8%, and 45.5%, respectively. Significant differences were observed in education level, family income, and social capital between elderly individuals with and without each of the six health risk behavior (all p-values < 0.05). Elderly individuals who reported smoking, physical inactivity, unhealthy dietary behavior, and sleep disorder had significantly lower HRQoL than those without these unhealthy behaviors (all p-values < 0.05). SEM analysis showed that SES and social capital positively associated with alcohol consumption. Social capital negatively associated with smoking, physical inactivity, unhealthy dietary behavior, and sleep disorder. SES negatively associated with smoking, physical inactivity, unhealthy dietary behavior, unhealthy weight, and sleep disorder. Smoking, physical inactivity, unhealthy dietary behavior, and sleep disorder correlated with poorer HRQoL. Conclusions: Chinese older adults demonstrated a high incidence of health risk behaviors, especially for physical inactivity (62.5%) and unhealthy dietary behavior (45.7%). Social capital and SES were correlated with the elderly's HRQoL, as well as with the health risk behaviors. Health risk behaviors played potential mediating role on the relationship between social capital, SES, and HRQoL in Chinese older adults.
Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study
Authors: Scherb Hagen , Clinic Japan Hayashi Osaka Keiji Hayashi Children's 
Published: June 2020

Abstract
Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046. Conclusions: This study shows increased low birth weight prevalence related to the Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.
Effects of red and blue light on leaf anatomy, CO2 assimilation, and the photosynthetic electron transport capacity of sweet pepper (Capsicum annuum L.) seedlings
Authors: Li Yan , Xin Guofeng , Liu Chang , Shi Qinghua , Yang Fengjuan , Wei Min 
Published: June 2020

Abstract
Background: The red (R) and blue (B) light wavelengths are known to influence many plant physiological processes during growth and development, particularly photosynthesis. To understand how R and B light influences plant photomorphogenesis and photosynthesis, we investigated changes in leaf anatomy, chlorophyll fluorescence and photosynthetic parameters, and ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rubisco) and Calvin cycle-related enzymes expression and their activities in sweet pepper (Capsicum annuum L.) seedlings exposed to four light qualities: monochromatic white (W, control), R, B and mixed R and B (RB) light with the same photosynthetic photon flux density (PPFD) of 300 μmol/m2·s. Results: The results revealed that seedlings grown under R light had lower biomass accumulation, CO2 assimilation and photosystem II (PSII) electron transportation compared to plants grown under other treatments. These changes are probably due to inactivation of the photosystem (PS). Biomass accumulation and CO2 assimilation were significantly enriched in B- and RB-grown plants, especially the latter treatment. Their leaves were also thicker, and photosynthetic electron transport capacity, as well as the photosynthetic rate were enhanced. The up-regulation of the expression and activities of Rubisco, fructose-1, 6-bisphosphatase (FBPase) and glyceraldehyde-phosphate dehydrogenase (GAPDH), which involved in the Calvin cycle and are probably the main enzymatic factors contributing to RuBP (ribulose-1, 5-bisphosphate) synthesis, were also increased. Conclusions: Mixed R and B light altered plant photomorphogenesis and photosynthesis, mainly through its effects on leaf anatomy, photosynthetic electron transportation and the expression and activities of key Calvin cycle enzymes.
Establishment of Egyptian developmental screening chart for infants from birth up to 30 months
Authors: Shafie Ali M. El , Omar Zein A.L. , Bashir Mai M. , mahmoud sorour fayez , Basma El-sayedamr M. , Hussein Ahmed E. , Bahbah Wael A. 
Published: June 2020

Abstract
Background: Detecting developmental delay in infants is an ongoing world commitment, especially for those below three years old. Early detection prevents the adverse outcomes in this critical period of age. To accurately assess the development of children; a culturally appropriate screening tool must be used. Egypt lacks such tool and multiple studies have shown that western tools are not suitable in other cultures.Objectives: To establish sufficient easy, rapid, culturally appropriate and applicable screening chart for early detection of developmental delay among Egyptian infants from birth up to 30 months.Methods: A cross sectional study was carried out on 1503 Egyptian infants of both genders aged from birth up to 30 months assumed to have normal development according to the inclusion and exclusion criteria. They were selected from vaccination centers and well-baby clinics. Developmental milestones from Baroda development screening test (BDST) were applied on them. Egyptian infants' developmental millstones scores were analyzed and carefully prepared in tables and charts. 97% pass levels of developmental achievements of infants represent the threshold below which infants are considered delayed. A z-score chart for motor and mental development follow up was designed by calculating each age group achievement.Results: The designed Egyptian Developmental Screening Chart (EDSC) is represented in a chart format with two curves 50% and 97% pass level. Infants considered delayed when infant's score below 97% pass level. Results revealed a statistically significant difference between Egyptian and Baroda chart at 50% and 97%pass levels.Conclusions: Extensive revision of the BDST was needed in order to create a more culturally appropriate Egyptian screening chart. This is the first study to create an Egyptian-specific screening tool, to be rapid and easy to use in Egypt for early detection of developmental delay and enabling early intervention practices. A z-score curve is reliable for follow up motor and mental development by calculating each age group achievement.
Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
Authors: Schneider Matthias F. , Fallah Mohammad A. , Mess Christian , Obser Tobias , Schneppenheim Reinhard , Alexander-Katz Alfredo , Schneider Stefan W. , Huck Volker 
Published: June 2020

Abstract
Background It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF's mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet interactions in haemostasis. Results Combining microfluidic tools with fluorescence and reflection interference contrast microscopy (RICM), here we show, that specific deletions in the A-domains of the biopolymer VWF affect both, adhesion and aggregation properties independently. Intuitively, the deletion of the A1-domain led to a significant decrease in both adhesion and aggregate formation of platelets. Nevertheless, the deletion of the A2-domain revealed a completely different picture, with a significant increase in formation of rolling aggregates (gain of function). We predict that the A2-domain effectively ‘masks’ the potential between the platelet glycoprotein (GP) Ib and the VWF A1-domain. Furthermore, the deletion of the A3-domain led to no significant variation in either of the two functional characteristics. Conclusions These data demonstrate that the macroscopic functional properties i.e. adhesion and aggregate formation cannot simply be assigned to the properties of one particular domain, but have to be explained by cooperative phenomena. The absence or presence of molecular entities likewise affects the properties (thermodynamic phenomenology) of its neighbours, therefore altering the macromolecular function.
A comparison of Passive Surveillance and Active Cluster-Based Surveillance for Dengue Fever in southern coastal Ecuador
Authors: Vitale Melissa , Lupone Christina D , Kenneson-Adams Aileen , Ochoa Robinson Jaramillo , Ordoñez Tania , Beltran-Ayala Efráin , Endy Timothy P. , Rosenbaum Paula F. , Stewart-Ibarra Anna M. 
Published: June 2020

Abstract
Background: Dengue is a major emerging infectious disease, endemic throughout the tropics and subtropics, with approximately 2.5 billion people at risk globally. Active (AS) and passive surveillance (PS), when combined, can improve our understanding of dengue’s complex disease dynamics to guide effective, targeted public health interventions. The objective of this study was to compare findings from the Ministry of Health (MoH) PS to a prospective AS arbovirus research study in Machala, Ecuador in 2014 and 2015. Methods: Dengue cases in the PS system were compared to laboratory confirmed acute dengue illness cases that entered the AS study during the study period. Variables of interest included age, class, and sex. Outbreak detection curves by epidemiologic week, overall cumulative incidence and age-specific incidence proportions were calculated. Descriptive statistics were tabulated for all variables of interest. Chi-square tests were performed to compare demographic characteristics between the AS and PS data sets in 2014 and 2015. Results: 177 and 245 cases were identified from 1/1/2014 to 12/31/2015 by PS and AS, respectively; nine cases appeared in both systems. AS identified a greater number of laboratory-confirmed cases in 2014, accounting for more than 60% of dengue cases in the study area. In 2015, the opposite trend was observed with PS identifying 60% of the dengue cases in the region. Peak transmission time, as noted by AS and PS was similar in 2014 whereas earlier detection was observed by AS in 2015.Younger patients were more frequently identified by PS, while older patients were identified more frequently by AS. The cumulative incidence proportion for laboratory confirmed dengue illness reported via PS to the MoH was 4.12 cases per 10,000 residents in 2014, and 2.21 cases per 10,000 residents in 2015.Conclusions: Each surveillance system captured distinct demographic subgroups within the Machala population, possibly due to differences in healthcare seeking behaviors, access to care, emerging threats of other viruses transmitted by the same mosquito vector and/or differences in clinical presentation. Integrating AS with pre-existing PS can aid in identifying additional cases in previously under diagnosed subpopulations, improving our understanding of disease dynamics, and facilitating the implementation of timely public health interventions..
A Recognition Algorithm of VGPO Jamming Based on Discrete Chirp-Fourier Transform
Authors: Wu Chuanzhang , Chen Baixiao 
Published: June 2020

Abstract
This paper addresses the recognition problem of velocity gate pull-oﬀ (VGPO) jamming from the target echo signal for the velocity-based tracking system. The discrete chirp-Fourier transform (DCFT) is studied in this paper to jointly estimate the chirp rates and frequencies of the target and jamming signals. Firstly, the scaling characteristic of the DCFT algorithm is explored. Then we focus on the quantitative eﬀect of the VGPO jamming signal by analyzing the jointly estimated results in each pulse. The quantitative eﬀect indicates that, as long as the estimated frequency is unchanged, the relationship between the estimated chirp rate and the pulse numbers is similar to the relationship between the frequency oﬀset of VGPO jamming and the time. Finally, by utilizing the joint estimated results in each pulse repetition interval and calculating the mean square to variance ratio (MSVR) of the normalized estimated chirp rate, the VGPO jamming can be recognized. Simulation results show that the jamming signal and the target echo become distinguishable with the proposed feature. Comparing to the existing works, the proposed method can correctly recognize the jamming signal with lower jamming-to-noise ratio (JNR) 5dB with less data needed, which means it can work eﬀectively in the early stage of interference implementation and shows great potential in practical applications.