bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tension between managerial and critical professional discourses in social work
Authors: Timor-Shlevin Shachar , Benjamin Orly 
Published: August 2020

Summary While managerialism is widely criticized for its deskilling effect on professional discourses, the evaluation of the power relations between managerialism and the critical professionalism that opposes it has not yet been sufficiently developed. To enable the assessment of fluctuations in these power relations, this study used in-depth interviews with 14 street-level social workers to examine the encounter between these discursive standpoints in the context of a specific case of an administrative request for critical professional programs to be implemented in the field. Findings The findings highlight the operation of recognition as a salient parameter of discursive power positions. We address three aspects of recognition—discursive, interpersonal, and institutional—and demonstrate the existence of a struggle over the acceptable professional standpoint in the institutionalized public field of social work. Applications Attention should be given to the different dimensions of recognition in order to enable the implementation of critical practice in the public field of social work. These dimensions can be addressed through broad training of various players in the field and the institutional backing of critical practice requirements.
Psychological distress among social workers
Authors: Kagan Maya , GreenblattKimron Lee 
Published: August 2020

Summary The purpose of the current study was to examine the moderating role of social support in the association between self-efficacy and psychological distress among social workers. The data were collected through a structured questionnaire administered to a sample of 726 social workers in Israel. Selected variables, found in previous studies to correlate with psychological distress, served in the current study as covariates: gender, years of professional experience, self-rated health, self-defined burnout, and self-reported loneliness. Findings The hierarchical multiple regression revealed that social workers who had more years of professional experience, better self-rated health, lower levels of burnout and of self-reported loneliness, reported lower levels of psychological distress. Higher levels of self-efficacy were found to be associated with lower levels of psychological distress only among social workers with lower levels of perceived social support. Application In the absence of adequate social support, self-efficacy can be an important resource for social workers, since it is related to lower levels of psychological distress. Hence, it is recommended that action be taken to promote awareness and enhance social workers’ self-efficacy at the academic level, from the initial stages of their socialization into the profession and at their work places. Also, action should be taken on the policy level to provide assistance with developing and maintaining social workers’ support mechanisms.
Intravascular Ultrasound Imaging During Aortoiliac Stenting: No Impact on Outcomes at 1 Year
Authors: Tsujimura Takuya , Takahara Mitsuyoshi , Iida Osamu , Yamauchi Yasutaka , Shintani Yoshiaki , Sugano Teruyasu , Yamamoto Yoshito , Kawasaki Daizo , Yokoi Hiroyoshi , Miyamoto Akira , Mano Toshiaki , Nakamura Masato 
Published: August 2020

Purpose To investigate the effect of intravascular ultrasound (IVUS) imaging use on clinical outcomes after aortoiliac stenting in patients with peripheral artery disease (PAD). Materials and Methods Subjects for this retrospective analysis were derived from the OMOTENASHI registry database, which contained 803 symptomatic PAD patients (Rutherford categories 2–4) who were treated with self-expanding stent implantation for aortoiliac atherosclerotic lesions at 61 centers in Japan between January 2014 and April 2016. Of the 803 patients, 545 (67.9%) patients (mean age 73±9 years; 453 men) underwent IVUS-supported stent implantation and were compared with the 258 patients (mean age 73±8 years; 217 men) treated without IVUS. A propensity score analysis of 138 matched pairs was conducted to compare treatment strategies and clinical outcomes between patients having IVUS-supported endovascular therapy and those treated without IVUS. Results Endovascular strategies and postoperative medications were not significantly different between the IVUS and no-IVUS groups. A procedure time under 1 hour was less frequent in the IVUS group, which had a longer fluoroscopy time. The 12-month restenosis rate was not significantly different between the 2 groups [10.2% (95% CI 6.9 to 14.9%) vs 10.3% (95% CI 5.4 to 18.6%), p=0.99]. There was no interaction between baseline characteristics and the association of IVUS use with restenosis risk. Conclusion Propensity score matching analysis revealed that duration and fluoroscopy time during IVUS-supported procedures were significantly longer than in cases without IVUS use, whereas the 12-month restenosis rate was not significantly different between the groups. IVUS use in aortoiliac lesions may be unnecessary.
GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival
Authors: Yang Dingquan , Ji Fujian , Li Yanqing , Jiao Yan , Fang Xuedong 
Published: August 2020

Background and Objective: Liver cancer is a malignancy with a poor prognosis. G protein signaling modulator 2 is mainly related to cell division and cell cycle regulation. In this review, the relationship between G protein signaling modulator 2 and clinical characteristics of patients with liver cancer has been explored, especially with respect to its prognostic value. Methods: G protein signaling modulator 2 messenger RNA expression and clinicopathological characteristics of patients with liver cancer were obtained from The Cancer Genome Atlas. The expression level of G protein signaling modulator 2 RNA-Seq was validated by using Gene Expression Omnibus. Chi-square test was performed to evaluate the relationship between G protein signaling modulator 2 expression and clinical characteristics. The threshold value of G protein signaling modulator 2 in the diagnosis of liver cancer was evaluated by a receiver–operating characteristic curve. Cox regression analysis and Kaplan-Meier curves were performed to evaluate the relationship between G protein signaling modulator 2 and liver cancer prognosis, which included overall and residual-free survival, and explored the prognostic value of G protein signaling modulator 2. Liver cancer survival analyses were validated by using the data of G protein signaling modulator 2 RNA-Seq from the International Cancer Genome Consortium. Results: The expression level of G protein signaling modulator 2 messenger RNA was remarkably higher in liver cancer than that in healthy tissues ( P < 2.2 × e−16), which was also validated by data from the GSE14520 database. In addition, high G protein signaling modulator 2 expression significantly correlated with histological grade ( P = .020), vital status ( P < .001), clinical ( P = .001), and T stage ( P = .001). The receiver–operating characteristic curves showed G protein signaling modulator 2 to be an advantageous diagnostic molecule for liver cancer (area under curve = 0.893). Furthermore, the results of Cox analysis and Kaplan-Meier curves suggested that the upregulation of G protein signaling modulator 2 expression is linked to poor prognosis and G protein signaling modulator 2 messenger RNA could be an independent predictor for liver cancer, which was validated by data from the International Cancer Genome Consortium database. Conclusions: G protein signaling modulator 2 messenger RNA was overexpressed in liver cancer, and G protein signaling modulator 2 is an independent prognostic factor. G protein signaling modulator 2 is expected to be a treatment target for cancer.
Rapid On-Site Evaluation During Radial Endobronchial Ultrasound–Guided Transbronchial Lung Biopsy for the Diagnosis of Peripheral Pulmonary Lesions
Authors: Xu Chunhua , Wang Wei , Yuan Qi , Hu Huidi , Li Li , Yang Rusong 
Published: August 2020

Objective: To evaluate the diagnostic value of radial endobronchial ultrasound (R-EBUS) combination with rapid on-site evaluation (ROSE) guided transbronchial lung biopsy (TBLB) for peripheral pulmonary lesions. Methods: Peripheral pulmonary lesions identified by computed tomography underwent R-EBUS with or without ROSE randomly from February 2016 to August 2017. The diagnostic yield and the operation time were compared. Results: In total, 158 patients were involved in and completed this research, including 84 cases in the group of R-EBUS with ROSE, and 74 in the group without ROSE. The diagnostic yield of ROSE group was 85.7%. Among these positive cases, 69.4% cases were malignant tumors, and 30.6% cases were benign lesions. The operation time was (24.6 ± 6.3) min. In the group without ROSE, the diagnostic yield was 70.3%, including 35 malignant tumors (67.3%), and 17 benign lesions (32.7%). The operation time was (31.5 ± 6.8) min. There were significant differences between both groups in the diagnostic yield (χ2 = 5.556, P = 0.018) and in the operation time (t = 3.187, P < 0.01). No serious procedure related complications were observed, such as pneumothorax and hemorrhage. Conclusion: ROSE can improve the diagnostic yield, and shorten the operation time. R-EBUS combined with ROSE is a safe and effective technique for peripheral pulmonary lesions.
The impact of pre-operative biologic therapy on post-operative surgical outcomes in ulcerative colitis: a systematic review and meta-analysis
Authors: Zanelli Jasmine , Chandrapalan Subashini , Patel Abhilasha , Arasaradnam Ramesh P. 
Published: August 2020

Background and aims: Biologic therapy has emerged as an effective modality amongst the medical treatment options available for ulcerative colitis (UC). However, its impact on post-operative care in patients with UC is still debatable. This review evaluates the risk of post-operative complications following biologic treatment in patients with UC. Methods: A systematic search of the relevant databases was conducted with the aim of identifying studies that compared the post-operative complication rates of UC patients who were either exposed or not exposed to a biologic therapy prior to their surgery. Outcomes of interest included both infection-related complications and overall surgical morbidity. Pooled odds-ratio (OR) and 95% confidence intervals (CI) were calculated using Review Manager 5.3. Results: In all, 20 studies, reviewing a total of 12,494 patients with UC, were included in the meta-analysis. Of these, 2254 patients were exposed to a biologic therapy prior to surgery. The pooled ORs for infection-related complications ( n = 8067) and overall complications ( n = 11,869) were 0.98 (95% CI 0.66–1.45) and 1.14 (95% CI 1.04–1.28), respectively, which suggested that there was no significant association between the use of pre-operative biologic therapy and post-operative complications. Interestingly, the interval between the last dose of biologic therapy and surgery did not influence the risk of having a post-operative infection. Conclusions: This meta-analysis suggests that pre-operative biologic therapy does not increase the overall risk of having post-operative infection-related or other complications. PROSPERO registration id-CRD42019141827.
Microvascular density assessed by CD31 predicts clinical benefit upon bevacizumab treatment in metastatic colorectal cancer: results of the PassionATE study, a translational prospective Phase II study of capecitabine and irinotecan plus bevacizumab followed by capecitabine and oxaliplatin plus bevacizumab or the reverse sequence in patients in mCRC
Authors: Bianconi Daniela , Herac Merima , Posch Florian , Schmeidl Margit , Unseld Matthias , Kieler Markus , Brettner Robert , Müllauer Leonhard , Riedl Jakob , Gerger Armin , Scheithauer Werner , Prager Gerald 
Published: August 2020

Background: Targeted therapies offer novel opportunities to explore biomarkers based on their mode of action. Taking this into consideration, we evaluated six angiogenesis-related proteins as potential predictive biomarkers, which expression might predict the benefit of bevacizumab treatment in patients with metastatic colorectal cancer (mCRC). Methods: This was a phase II multicenter, two-armed, randomized study, in which patients with mCRC were treated with XELIRI (capecitabine and irinotecan) plus bevacizumab followed by XELOX (capecitabine and oxaliplatin) plus bevacizumab (Arm A) or the reverse sequence (Arm B). Tissue expression level of six prespecified candidates [microvessel density assessed by CD31, PTEN, αV integrin, CD98hc, uPAR and NRP-1] was analyzed via immunohistochemistry. The prognostic impact on survival was quantified using the Cox regression model. The predictive potential for benefit from Arm A versus Arm B treatment was investigated by fitting an interaction between the biomarkers and treatment assignment within a multivariable Cox model. Results: In total, 74 out of 126 patients were included in the analysis. The expression of PTEN, αV integrin, uPAR and NRP-1 was not associated with progression-free survival (PFS) or overall survival (OS). For the first time, we identified that patients with tumors expressing CD98hc had a longer PFS than patients without CD98hc-expression ( p = 0.032). More importantly, and in accordance with previous studies, low microvessel density was found to be associated with a reduced PFS [adjusted HR per doubling of CD31-expression ( p = 0.53, 95% confidence interval: 0.30–0.95, p = 0.034)]. Conclusions: These results can contribute to the development of a personalized strategy for the treatment of mCRC with bevacizumab.
Effects of Foot Strike Techniques on Running Biomechanics: A Systematic Review and Meta-analysis
Authors: Xu Yilin , Yuan Peng , Wang Ran , Wang Dan , Liu Jia , Zhou Hui 
Published: August 2020

Content: Distance running is one of the most popular physical activities, and running-related injuries (RRIs) are also common. Foot strike patterns have been suggested to affect biomechanical variables related to RRI risks. Objective: To determine the effects of foot strike techniques on running biomechanics. Data Sources: The databases of Web of Science, PubMed, EMBASE, and EBSCO were searched from database inception through November 2018. Study Selection: The initial electronic search found 723 studies. Of these, 26 studies with a total of 472 participants were eligible for inclusion in this meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 4. Data Extraction: Means, standard deviations, and sample sizes were extracted from the eligible studies, and the standard mean differences (SMDs) were obtained for biomechanical variables between forefoot strike (FFS) and rearfoot strike (RFS) groups using a random-effects model. Results: FFS showed significantly smaller magnitude (SMD, −1.84; 95% CI, −2.29 to −1.38; P < 0.001) and loading rate (mean: SMD, −2.1; 95% CI, −3.18 to −1.01; P < 0.001; peak: SMD, −1.77; 95% CI, −2.21 to −1.33; P < 0.001) of impact force, ankle stiffness (SMD, −1.69; 95% CI, −2.46 to −0.92; P < 0.001), knee extension moment (SMD, −0.64; 95% CI, −0.98 to −0.3; P < 0.001), knee eccentric power (SMD, −2.03; 95% CI, −2.51 to −1.54; P < 0.001), knee negative work (SMD, −1.56; 95% CI, −2.11 to −1.00; P < 0.001), and patellofemoral joint stress (peak: SMD, −0.71; 95% CI, −1.28 to −0.14; P = 0.01; integral: SMD, −0.63; 95% CI, −1.11 to −0.15; P = 0.01) compared with RFS. However, FFS significantly increased ankle plantarflexion moment (SMD, 1.31; 95% CI, 0.66 to 1.96; P < 0.001), eccentric power (SMD, 1.63; 95% CI, 1.18 to 2.08; P < 0.001), negative work (SMD, 2.60; 95% CI, 1.02 to 4.18; P = 0.001), and axial contact force (SMD, 1.26; 95% CI, 0.93 to 1.6; P < 0.001) compared with RFS. Conclusion: Running with RFS imposed higher biomechanical loads on overall ground impact and knee and patellofemoral joints, whereas FFS imposed higher biomechanical loads on the ankle joint and Achilles tendon. The modification of strike techniques may affect the specific biomechanical loads experienced on relevant structures or tissues during running.
Association between change in cardiorespiratory fitness and incident hypertension in Swedish adults
Authors: Holmlund Tobias , Ekblom Björn , Börjesson Mats , Andersson Gunnar , Wallin Peter , Ekblom-Bak Elin 
Published: August 2020

AbstractAimsTo explore how change in cardiorespiratory fitness is associated with incident hypertension in adults, and whether the association varies between sex, age, body mass index, cardiorespiratory fitness at baseline and follow-up time. A second aim is to study how change in other lifestyle-related variables affects the results.MethodsA total of 91,728 participants (48% women), normotensive at baseline, with two examinations from occupational health service screenings between 1982 and 2019 (mean duration 4.3 years) were included. Cardiorespiratory fitness was assessed as estimated maximal oxygen consumption using submaximal cycle testing. Change in cardiorespiratory fitness was expressed as the percentage change per year. Incident hypertension was defined as systolic blood pressure of 140 mmHg or greater or diastolic blood pressure of 90 mmHg or greater, or self-reported physician-diagnosed hypertension, at second examination.ResultsA large increase (≥3% annual change) in cardiorespiratory fitness was associated with a 11% lower risk of incident hypertension compared with maintainers (–1 to +1%), after multi-adjustment including change in smoking, body mass index, diet, stress and exercise habits. On the contrary, a small (–1 to −&lt;3%) and large (≥–3%) decrease in cardiorespiratory fitness associated with a 21% and 25% higher risk compared with maintainers. Longer duration between the examinations was associated with stronger risk associations. Preserving, or changing to, risk level for the other lifestyle variables was associated with a higher risk of incident hypertension. However, a simultaneous maintenance of or increase in cardiorespiratory fitness attenuated the risk associated with smoking, and stress.ConclusionPreserving or increasing cardiorespiratory fitness should be part of any long-term strategy to decrease the risk of incident hypertension.
Clinical and sociodemographic factors associated with oral health knowledge, attitude, and practices of adolescents in Nigeria
Authors: Lawal Folake Barakat , Oke Gbemisola Aderemi 
Published: August 2020

Objectives: The institution of appropriate oral health promotion programs targeted at adolescents in schools in developing countries requires baseline information on their oral health knowledge, attitude, and practices as well as associated factors influencing it, which are unknown. This study assessed clinical and sociodemographic factors associated with oral health knowledge, attitude, and practices of adolescents in Ibadan, Nigeria. Methods: Two-thousand and ninety-seven students aged 12–18 years were recruited from 30 randomly selected secondary schools in a cross-sectional study conducted in Ibadan, Nigeria. Data were obtained through a questionnaire on oral health knowledge, attitude, and practices, and sociodemographic characteristics. Oral examination was conducted to assess the clinical oral condition of the adolescents. Data were analyzed with SPSS. The higher the percentage scores, the better the oral health knowledge, attitude, and practices, and overall awareness of oral health. Results: The oral health knowledge score ranged from 0% to 60%; mean oral health knowledge score was 15.1% (±6.6%). The oral health attitude score ranged from 0% to 91.3%; mean oral health attitude score was 44.5% (±14.3%). The oral health practices score ranged from 0% to 88.9%, and mean oral health practices score was 42.5% (±13.8%). The mean oral health knowledge, attitude, and practices score was 43.8% (±11.4%). A total of 1537 (73.3%) participants had unhealthy periodontium and 98 (4.7%) had dental caries. Students who were 12–15 years (odds ratio = 1.7, 95% confidence interval = 1.4–2.0, p < 0.001), females (odds ratio = 1.2, 95% confidence interval = 1.0–1.5, p = 0.024), offspring of skilled workers (odds ratio = 1.5, 95% confidence interval = 1.1–2.0, p = 0.010), previously educated about oral health (odds ratio = 1.3, 95% confidence interval = 1.0–1.7, p = 0.023), consulted the dentist (odds ratio = 1.9, 95% confidence interval = 1.2–3.1, p = 0.009), or had unhealthy periodontal condition (odds ratio = 1.2, 95% confidence interval = 1.0–1.5, p = 0.042) were more likely to have higher oral health knowledge, attitude, and practices scores or awareness than others. Conclusion: Better knowledge, attitude, and practices score was associated with younger age group, higher occupational class, previous oral health education, dental consultation, and having unhealthy periodontal condition.
Availability and reimbursement of biological products for severe asthma in Bulgaria
Authors: Milushewa Petya , Doneva Miglena , Petrova Guenka 
Published: August 2020

Objectives: This study aims to analyze the reimbursement and cost of biological therapy for severe asthma in Bulgaria during 2014–2019 from the perspective of the National Health Insurance Fund. Methods: It is a retrospective, Marco-costing, top-down study of the expenditures for biological products for severe asthma. The changes in the cost paid by the National Health Insurance Fund per year, per product, and per patient during 2015–2020 were systematized and calculated. The utilization of biologicals was analyzed by calculating the defined daily dose/1000inh/day. Three databases were searched—the European Medicines Agency for the date of marketing authorization of biological products, National Council of Prices and Reimbursement for the date of their respective inclusion in the positive drug list, and National Health Insurance Fund about the number of patients with asthma, reimbursed sum for all asthma patients, and number of packages sold of biological products. Results: At the end of 2019, five international non-proprietary names of biologicals with indication for severe asthma had received European marketing authorization, and three of them were included in the Bulgarian positive drug list—omalizumab, mepolizumab, and benralizumab with a 75% reimbursement. Upon their introduction into the positive drug list, the reimbursed expenditures for asthma therapy started to increase from 27 million in 2014 to 33 million BGN in 2019 (€13.5–€16.5 million). The cost of therapy with biologicals rose from 16% to 24% of all anti-asthmatic medicines budget. The National Health Insurance Fund database reported that between 47,000 and 52,000 of patients with asthma, 466 are on biological therapy. The yearly cost of one asthma patient ranges between 512 and 615 BGN (€258–€307), and the yearly per-patient cost of severe asthma is 16,666 BGN (appr. €8333). Total utilization in defined daily dose/1000inh/day increases from 0.0199 to 0.0383 from 2015 to 2019. Conclusion: The access to biological therapy through the reimbursement system has improved during the last 3 years. The cost of therapy is posing a high burden on the National Health Insurance Fund and on the patients and is expected to increase due to the small number of patients on biological therapy currently in comparison to all reimbursed asthmatics.