bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working capital efficiency and capital structure decisions in Egypt: the effect of foreign currency exchange risk exposure under IAS 21
Authors: Mansour Karim 
Published: December 2024

PurposeThis research aims to test the impact of working capital efficiency (WCE) on capital structure decisions (CSD) in Egypt and investigate the moderating role of foreign currency exchange risk exposure under IAS 21 in this relationship.Design/methodology/approachThis research relies on data obtained from the financial reports of a sample consisting of 65 listed firms on the Egyptian stock exchange from 2012 to 2022, where the data is processed using the generalized method of moments (GMM).FindingsThe results reveal that the Egyptian industrial firms with higher WCE rely more on total debt finance (TDF) and long-term debt finance (LODF) and depend less on short-term debt finance (SHODF). Furthermore, the results indicated that foreign currency exchange gains (EXCG) strengthen the positive effect of high WCE on TDF and LODF. Conversely, foreign currency exchange losses (EXCL) weaken this positive effect. Furthermore, EXCL weakens the negative effect of WCE on SHODF. Moreover, the additional analysis yielded evidence regarding the influence of WCE’s components on CSD.Research limitations/implicationsThis research has some limitations. First, the relatively small sample size. Second, foreign currency exchange gains or losses under IAS 21 may not fully capture all aspects of currency risk exposure.Practical implicationsThis research provides valuable insights for firms operating in emerging markets which face unique challenges related to financing, liquidity and foreign currency exposure. Also, it contributes to the development of more efficient and sustainable financial markets in emerging economies. Furthermore, it offers insights for policymakers and regulators in emerging markets regarding the implications of IFRS adoption, specifically IAS 21.Originality/valueThis research contributes to the limited existing literature that has explored the influence of WCE on CSD in developed economies. Additionally, it expands the body of knowledge concerning CSD in emerging markets, as the investigation of the relationship between WCE and CSD remains an under-researched area. Moreover, this research empirically analyzes the moderating impact of foreign currency exchange risk exposure under IAS 21 on the relationship between WCE and CSD, which has not been previously examined.
Towards a framework of menu research: insights from the multiple level perspective and signaling theory
Authors: Nie Xiangzhen , Zhao Weibing Max , Guan Jieqi 
Published: December 2024

PurposeThis study conducts a systematic review of research on restaurant menus and uses a detailed analytical framework to examine how these menus are developed. It incorporates insights from the multi-level perspective (MLP) and signaling theory (ST) to provide a thorough and nuanced analysis of the factors that influence menu design.Design/methodology/approachThis study scrutinizes 120 peer-reviewed articles published from 2004 to 2023 at A or A* journals, as classified by the Australian Business Deans Council (ABDC). Following a comprehensive analytical framework, it endeavors to delve into the intricate complexities of menu research, giving particular emphasis to the latest trends and developments. Two tools, namely CiteSpace and VOSviewer, were utilized to perform a thorough bibliometric analysis of the publications.FindingsThis study explores menu design from macro, meso and micro perspectives, illustrating that menus are more than simple lists of food items. Instead, they are shaped by societal norms, values, market dynamics, industry standards and consumer preferences. It underscores the vital role of menu as a communication and management tool in engaging consumers and influencing their dining choices and decisions.Originality/valueThis study represents the pioneering effort to incorporate the MLP and ST into the realm of menu research, providing a novel approach to the systematic review of related literature. It offers a distinctive macro-level theoretical perspective on menu dynamics, providing insights that are relevant to industry professionals, policymakers, academics and the public.
A binary-tree subdivision method for evaluation of singular integrals with discontinuous kernel in 3D BEM
Authors: Ju Chuanming , Chen Jiehao , Li Ning , Du Xianfeng 
Published: December 2024

PurposeA binary-tree subdivision method (BTSM) for numerical evaluation of weakly singular integrals with discontinuous kernel in the three-dimensional (3D) boundary element method (BEM) is presented in this paper.Design/methodology/approachIn this method, the singular boundary element is split into two sub-elements and subdivided recursively until the termination criterion is met and the subdivision is stopped. Then, the source point is surrounded by one or more spherical cavities determined by the discontinuous kernel function. The sub-elements located in spherical cavities will be eliminated, and the regular triangular or rectangle elements are employed to fill the spherical cavities.FindingsWith the proposed method, the obtained sub-elements are automatically refined as they approach the source point, and they are “good” in shape and size for standard Gaussian quadrature. Thus, the proposed method can be used to evaluate singular integrals owing discontinuous kernel function accurately for cases of different element shapes and various source point locations.Originality/valueNumerical examples show that the BTSM is suitable for planar and curved elements of arbitrary regular or irregular shape at various source point locations, and the results have much better accuracy and robustness than conventional subdivision method (CSM) when the kernel function is discontinuous.
Mapping the landscape in HEIs: a systematic review of factors influencing EdTech adoption
Authors: Ravi Hariharan , Radhakrishna Vedapradha 
Published: December 2024

PurposeThe primary objective of this study was to aggregate and synthesize existing research findings in the realm of educational financing considering the adoption of educational technology (EdTech).Design/methodology/approachThe study involves the application of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Model, considering the journal articles from the last 10 years (2013 through 2023) obtained from the EBSCO and Emerald Insight databases to perform a systematic literature review.FindingsEdTech has given institutions new sources of income. The demand for online courses, credentials and other digital learning tools is rising, opening up new revenue potential for schools. Take-now-pay-post-placement is a new business model for the upskilling sector that enables learners to enroll in pertinent upskilling courses and pay back once they are placed (at a higher salary).Originality/valueThe development of technology has significantly lowered the overall educational cost, democratized access to education and empowered people to take charge of their education regardless of their location or socioeconomic status. With technology acting as a potent instrument to facilitate learning and close access barriers to education, this trend is expected to continue.
Magnetic macro drivers of labor efficiency: a study of high and low trade open economies
Authors: Suleman Shahida , Bibi Safia , Azam Muhammad , Thas Thaker Hassanudin Mohd , Cheong Calvin W.H. 
Published: December 2024

PurposeThis research aims to systematically compare the impact of macro drivers on labor efficiency (LEFF) in high and low trade openness economies, employing the Solow model as the theoretical framework.Design/methodology/approachThis study examines the influence of macro drivers on LEFF from 1995 to 2020, employing advanced panel regression methods such as stepwise regression (SR), fully modified ordinary least squares (FMOLS) and panel OLS. It utilizes Pedroni and Johansen co-integration tests to assess long-term dynamics and Granger causality tests to explore causal relationships between macro drivers and LEFF.FindingsThe results reveal both long-term and short-term relationships between LEFF and the macro drivers: gross capital formation (GCF), per capita income (PCI), foreign direct investment (FDI), trade openness (TOP) and gross national savings (GNS). The findings show that these macro drivers positively and significantly influence LEFF in both high and low TOP economies. Specifically, FDI, PCI and GNS have a more substantial positive impact on LEFF in low TOP economies, while GCF and TOP have a greater influence in high TOP economies. Furthermore, in high TOP economies, FDI, TOP and PCI exhibit a unidirectional relationship with LEFF, while GNS and GCF show a bidirectional relationship. In low TOP economies, all five macrodrivers exhibit bidirectional relationships with LEFF.Research limitations/implicationsThis research focuses on countries with high and low TOP, limiting the generalizability of its findings to other economic systems due to the unique trade, institutional and governance frameworks of these two distinct groups.Originality/valueTo the best of the authors’ knowledge, this study is the first to compare the impact of theoretical macro drivers on LEFF across groups of countries differentiated by their degrees of TOP (high and low).
Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis of the Reiwa Study
Authors: Sonehara Kei , Tateishi Kazunari , Yoh Kiyotaka , Usui Kazuhiro , Hosomi Yukio , Kishi Kazuma , Naka Go , Watanabe Kageaki , Tamano Shu , Uemura Kohei , Kunitoh Hideo 
Published: December 2024

ABSTRACTIntroductionFirst‐line osimertinib is widely used to treat patients with epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancers (NSCLC). In clinical practice, rechallenge therapy with another EGFR‐tyrosine kinase inhibitor (TKI) is often performed after first‐line TKI discontinuation owing to resistance or toxicity; however, the efficacy and toxicity of EGFR‐TKI rechallenge after first‐line osimertinib have not been adequately investigated. This study aimed to examine the efficacy and safety of EGFR‐TKI rechallenge with another TKI.MethodsThis multicenter prospective observational study enrolled patients with EGFR‐mutated NSCLC who received first‐line osimertinib and another EGFR‐TKI as second‐ or third‐line treatment between September 2018 and August 2020.ResultsFifty‐three patients received rechallenge with another EGFR‐TKI in the second‐line (n = 38, 71.7%) or third‐line (n = 15, 28.3%) setting. The primary reason for first‐line osimertinib discontinuation was toxicity in 32 (60.4%, 17 patients with pneumonitis) and disease progression in 20 (37.7%) patients. The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). The real‐world time to treatment failure (rwTTF) was 7.3 months. The rwTTF for the toxicity discontinuation and progressive disease discontinuation groups was 9.3 months and 5.1 months, respectively, (HR 1.61, p = 0.119). EGFR‐TKI rechallenge was discontinued due to toxicity in nine patients (17.0%), but no patient developed pneumonitis.ConclusionEGFR‐TKI rechallenge with another TKI is well tolerated in patients with EGFR‐mutated NSCLC. Thus, it may be a useful treatment option after first‐line osimertinib failure, especially after osimertinib discontinuation due to toxicity.
Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics
Authors: Al‐Naggar Iman M. , Antony Maria , Baker Dylan , Wang Lichao , Godoy Lucas Da Cunha , Kuo Chia‐Ling , Fraser Matthew O. , Smith Phillip P. , Xu Ming , Kuchel George A. 
Published: December 2024

AbstractLower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including incontinence greatly impact quality of life, isolation, depression, and nursing home admission. The aging bladder is hypothesized to be central to this decline, however, it remains difficult to pinpoint a singular strong driver of aging‐related bladder dysfunction. Many molecular and cellular changes occur with aging, contributing to decreased resilience to internal and external stressors, affecting urinary control and exacerbating LUTD. In this study, we examined whether cellular senescence, a cell fate involved in the etiology of most aging diseases, contributes to LUTD. We found that umbrella cells (UCs), luminal barrier uroepithelial cells in the bladder, show senescence features over the mouse lifespan. These polyploid UCs exhibit high cyclin D1 staining, previously reported to mediate tetraploidy‐induced senescence in vitro. These senescent UCs were not eliminated by the senolytic combination of Dasatinib and Quercetin. We also tested the effect of a high‐fat diet (HFD) and senescent cell transplantation on bladder function and showed that both models induce cystometric changes similar to natural aging in mice, with no effect of senolytics on HFD‐induced changes. These findings illustrate the heterogeneity of cellular senescence in varied tissues, while also providing potential insights into the origin of urothelial cancer. We conclude that senescence of bladder uroepithelial cells plays a role in normal physiology, namely in their role as barrier cells, helping promote uroepithelial integrity and impermeability and maintaining the urine‐blood barrier.
Prevalence and Clinical Significance of Early Repolarization in Athletes: A Systematic Review
Authors: Elenizi Khaled 
Published: December 2024

ABSTRACTIntroductionEarly repolarization (ER) is an electrocardiographic pattern characterized by J‐point and ST‐segment elevation, frequently observed in athletes. Initially deemed benign, recent studies suggest a possible association between ER and increased risks of cardiac arrhythmias and sudden cardiac death, necessitating a thorough examination of its clinical implications in athletes.MethodsA comprehensive literature review was conducted using MEDLINE (via PubMed) and EMBASE databases, focusing on articles related to ER in athletes. Search terms included “early repolarization,” and relevant studies were selected based on their focus on athletic populations. A total of 22 articles were included for detailed analysis.ResultsThe review encompassed 22 studies with a combined total of 44,326 athletes, revealing an overall mean ER prevalence of 31.6 ± 17.6 (p < 0.001). Most common location in the inferolateral region at 32.28%. The prevalence varied significantly across studies, ranging from 7% to 89%, influenced by factors such as age, gender distribution, and athletic discipline. Male athletes exhibited a higher incidence of ER compared with females, and endurance athletes showed a greater prevalence than strength athletes.ConclusionER is notably prevalent among athletes, especially males and those engaged in endurance sports. Current studies do not establish a direct association between ER and increased mortality in athletes. Further research is essential to refine risk stratification criteria and develop appropriate management strategies to ensure athlete safety while maintaining optimal performance levels.
The value of age of onset and family history as predictors of molecular diagnosis in a Swedish cohort of inherited retinal disease
Authors: De Geer Karl , Löfgren Stefan , Lindstrand Anna , Kvarnung Malin , Björck Erik 
Published: December 2024

AbstractPurposeThis study aimed to characterize clinical and genetic findings in a Swedish cohort with inherited retinal disease (IRD), identify predictors for achieving a molecular diagnosis and evaluate the effects of increased genetic testing over time.MethodsClinical and genetic data from 324 nonrelated IRD index individuals referred for genetic testing in the Stockholm region between 2016 and 2023 were collected retrospectively and analysed by clinical subtype, age of onset and testing period (2016–2020 vs. 2021–2023). Logistic regression was used to calculate odds ratios for age of onset and family history on the likelihood of achieving a molecular diagnosis.ResultsThe diagnostic yield was 55% and involved 56 genes. In 10% of solved individuals, the molecular diagnosis refined the clinical diagnosis. For each 1‐year increase in age of onset, the odds of achieving a molecular diagnosis decreased by 3% (odds ratio 0.97, 95% confidence interval 0.96–0.98). A positive family history doubled the odds (odds ratio 2.1, 95% confidence interval 1.3–3.4). The use of genetic testing increased 2.1‐fold and the number of molecular diagnoses increased 1.6‐fold relative to the population of the Stockholm region between the two testing periods.ConclusionThis study adds to the knowledge of the clinical and genetic landscape of IRDs in Sweden and establishes age of onset and family history as significant predictors for achieving a molecular diagnosis. Increased genetic testing on a population level substantially increased the number of individuals receiving a molecular diagnosis with a high diagnostic yield compared to other rare diseases.
Investigating dynamics in attentive and inattentive responding together with their contextual correlates using a novel mixture IRT model for intensive longitudinal data
Authors: Vogelsmeier Leonie V. D. E. , Uglanova Irina , Rein Manuel T. , Ulitzsch Esther 
Published: December 2024

AbstractIn ecological momentary assessment (EMA), respondents answer brief questionnaires about their current behaviours or experiences several times per day across multiple days. The frequent measurement enables a thorough grasp of the dynamics inherent in psychological constructs, but it also increases respondent burden. To lower this burden, respondents may engage in careless and insufficient effort responding (C/IER), leaving data contaminated with responses that do not reflect what researchers want to measure. We introduce a novel approach to investigating C/IER in EMA data. Our approach combines a confirmatory mixture item response theory model separating C/IER from attentive behaviour with latent Markov factor analysis. This enables gauging the occurrence of C/IER and studying transitions among states of different response behaviours including their contextual correlates. The approach can be implemented using R packages. An empirical application showcases the approach's efficacy in pinpointing C/IER instances and gaining insights into their underlying causes. We showcase that the approach identifies various C/IER response patterns but requires heterogeneous and negatively worded items to detect straightlining. In a simulation investigating robustness against unaccounted for changes in measurement models underlying attentive responses, the approach proved robust against heterogeneity in loading patterns but not against heterogeneity in factor structures. Extensions to accommodate the latter are discussed.
A systematic review of dexmedetomidine pharmacology in pediatric patients
Authors: O'Kane Aislinn , Quinney Sara K. , Kinney Emily , Bergstrom Richard F. , Tillman Emma M. 
Published: December 2024

AbstractDexmedetomidine is a centrally acting alpha‐2 agonist used for initiation and maintenance of procedural sedation and mechanical ventilation in adult and pediatric settings. It is commonly used in both pediatric and neonatal intensive care units. Dexmedetomidine requires extensive titration, and patients can be over or under‐sedated during titration, leading to adverse events such as hypotension and bradycardia, or inadequate sedation, which can result in self‐extubation. There is a critical need to identify factors that contribute to variation in metabolism, clearance, and downstream targets of dexmedetomidine so that individualized pediatric dosing regimens can be developed. This review is focused on dexmedetomidine pharmacokinetics and pharmacodynamics in the pediatric population and dexmedetomidine‐related pharmacogenes in both adults and children. We found that the strongest predictors of dexmedetomidine pharmacokinetics were age and size. Multiple pharmacogenes of significance have been identified, including ADRA2A, UGT2B10, UGT1A4, CYP1A2, CYP2A6, and CYP2D6. Evidence is weak for the correlation of these individual polymorphic genes with dexmedetomidine pharmacokinetics/dynamics, though there may be a polygenetic influence on pharmacologic response. This review provides a comprehensive overview of the genomic data gathered to date. We aim to summarize current pharmacologic studies regarding dexmedetomidine use and pharmacology in pediatric patients.
Radiomic‐based biomarkers: Transforming age and body composition metrics into personalized age‐informed indices
Authors: Alikhani Radin , Horbal Steven R. , Rothberg Amy E. , Pai Manjunath P. 
Published: December 2024

AbstractChronological age has been the standard for quantifying the aging process. While it is simple to quantify it cannot fully discern the biological variability of aging between individuals. The growing body of interest in this variability of human aging has led to the introduction of new biomarkers to operationalize biological age. The inclusion of body composition may provide additional value to biological aging as a prediction and estimation factor of individual health outcomes. Diagnostic images based on radiomic techniques such as Computed Tomography contain an untapped wealth of patient‐specific data that remain inaccessible to healthcare providers. These images are beneficial for collecting information from body composition that adds precision and granularity when compared to traditional measures. This information can subsequently be aggregated to construct models for changes in the human body associated with aging. In addition, aging leads to a natural decline in the best parameter of drug dosing in older adults, glomerular filtration rate. Since the conventional models of kidney function are correlated with age and body composition, the radiomic biomarkers representing age‐related changes in body composition may also serve as potential new imaging biomarkers of kidney function for personalized dosing. Our review introduces potential radiomic biomarkers as measures of body composition change targeting the aging processes. As a functional example, we have hypothesized an age‐related model of radiomics as a covariate of kidney function to improve personalized dosing. Future research focusing on evaluating this hypothesis in human subject studies is acknowledged.