bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC01089 inhibits the progression of cervical cancer via inhibiting miR‐27a‐3p and increasing BTG2
Authors: Li Shuoxi , Han Yu , Liang Xuesong , Zhao Min 
Published: October 2020

AbstractBackgroundIncreasing evidence confirms that long non‐coding RNA (lncRNA) has a vital impact on the procession of cervical cancer (CC). The present study aimed to investigate the clinical significance of LINC01089 in CC, as well as explore its biological functions and potential molecular mechanisms.MethodsA quantitative real‐time polymerase chain reaction (qRT‐PCR) was utilized to investigate the expression of LINC01089 and miR‐27a‐3p in CC cells and tissues. Analysis of the correlation between the expression level of LINC01089 and the clinical pathological parameters of CC was then conducted. The human CC cell lines HeLa and SiHa were utilized for transfection to establish a gain‐of‐function model and loss‐of‐function models. Western blotting and a qRT‐PCR were performed to detect B‐cell translocation gene‐2 (BTG2) expression in CC cells. Cell counting kit (CCK)‐8 and 5‐bromo‐2‐deoxyuridine (BrdU) assays were performed to detect the proliferation of CC cells. The transwell method was employed to evaluate the migration and invasion of CC cells. The interactions between LINC01089 and miR‐27a‐3p were verified by bioinformatics, a dual luciferase reporter gene experiment and a RNA immunoprecipitation experiment, respectively.ResultsThe expression of LINC01089 in CC was markedly down‐regulated. The low expression of LINC01089 in CC was closely associated with a larger tumor size and positive lymph node metastasis. Moreover, overexpression of LINC01089 impeded the proliferation and metastasis of CC cells, whereas knockdown of LINC01089 had the opposite biological functions. In terms of mechanism, LINC01089 could sponge miR‐27a‐3p and indirectly up‐regulate BTG2 expression.ConclusionsLINC01089, as a tumor suppressor, impedes the development of CC by targeting miR‐27a‐3p to up‐regulate BTG2 expression.
Clique‐convergence is undecidable for automatic graphs
Authors: Cedillo C. , Pizaña M. A. 
Published: October 2020

AbstractThe clique operator transforms a graph into its clique graph , which is the intersection graph of all the (maximal) cliques of . Iterated clique graphs are then defined by , . If there are some such that , then we say that is clique‐convergent. The clique graph operator and iterated clique graphs have been studied extensively, but no characterization for clique‐convergence has been found so far. Automatic graphs are (not necessarily finite) graphs whose vertices and edges can be recognized by finite automata. Automatic graphs (and automatic structures) have strong decidability properties inherited from the finite automata defining them. Here we prove that clique‐convergence is algorithmically undecidable for the class of automatic graphs. Moreover, the problem remains undecidable, if we reduce to the class that contain only quasi‐clique‐Helly and bounded degree graphs. As a consequence, it follows that clique‐convergence for automatic graphs is not first‐order expressible.
Phase 1 study of pomalidomide in children with recurrent, refractory, and progressive central nervous system tumors: A Pediatric Brain Tumor Consortium trial
Authors: Fangusaro Jason , Mitchell Duane A. , Kocak Mehmet , Robinson Giles W. , Baxter Patricia Ann , Hwang Eugene I. , Huang Jianping , Onar‐Thomas Arzu , Dunkel Ira J. , Fouladi Maryam , Warren Katherine E. 
Published: October 2020

AbstractBackgroundCentral nervous system (CNS) malignancies are the most common solid tumors among children, and novel therapies are needed to help improve survival. Pomalidomide is an immunomodulatory agent that displays antiangiogenic and cytotoxic activity, making it an appropriate candidate to explore in pediatric CNS tumors.MethodsA phase 1 first in pediatric trial of pomalidomide was conducted in children with recurrent, progressive, and refractory CNS tumors. The primary objective was to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) when given orally once daily for 21 consecutive days of a 28‐day cycle. Once the MTD was established, 12 additional patients were enrolled on expansion cohorts based on age and steroid use.ResultsTwenty‐nine children were enrolled and 25 were evaluable for dose‐limiting toxicity (DLT). The MTD was 2.6 mg/m2 (dose level 2). Four DLTs were observed in three patients at dose level 3 (3.4 mg/m2) includeding grade 3 diarrhea, grade 3 thrombocytopenia, grade 3 lung infection, and grade 4 neutropenia. The most common adverse events were grade 1 and 2 myelosuppression. One patient with an oligodendroglioma had stable disease for nine cycles, and a second patient with an anaplastic pleomorphic xanthoastrocytoma achieved a sustained partial response. Immunologic analyses suggested that pomalidomide triggers immunomodulation.ConclusionsThe MTD of pomalidomide is 2.6 mg/m2. It was well tolerated, and immune correlates showed a serum immune response. These data led to an industry‐sponsored phase 2 trial of pomalidomide monotherapy in children with recurrent brain tumors (NCT03257631).
Design and optimization of tapered carbon‐fiber‐reinforced polymer rim for carbon/aluminum assembled wheel
Authors: Wang Dengfeng , Xu Wenchao , Wang Yong , Gao Jingbo 
Published: October 2020

AbstractA multi‐objective integrated optimization framework that considers the manufacturing process in the design of a tapered carbon‐fiber‐reinforced polymer (CFRP) rim structure was established. Firstly, the three‐zone symmetrically stacked CFRP rim structure was proposed and modeled. The bending and radial fatigue and 13° impact of the carbon/aluminum‐assembled wheel composed of CFRP rim and aluminum alloy spoke were analysed. Coupling lay‐up thickness, sequence and angle as design variables, multi‐objective integrated optimization design for the tapered CFRP rim structure was performed through radial basis function neural network surrogate model combined with an elitist non‐dominated sorting genetic algorithm approach. Pareto‐optimal solutions were obtained, and the trade‐off solution was selected through grey relational analysis coupled with entropy weighting method. Finally, the tapered CFRP rim was manufactured through molding and autoclave forming technology. The CFRP rim has a weight saving of 17.2% compared with the previously developed forged magnesium alloy rim of the same size. The bending and radial fatigue and 13° impact performance of the assembled wheel were then validated by corresponding physical test, results of which met GB 36581‐2018 standard.
Impact of COVID‐19 on glycaemic control: a retrospective cohort study in a local district general hospital
Authors: Saqib Aaisha , Solanki Pratik , Carroll Matthew , Gough Andrew , Oguntolu Victor 
Published: October 2020

The aim of our study was to review how COVID‐19 infection affects glycaemic control. We retrospectively reviewed case notes of 55 patients and found no episodes of uncontrolled hyperglycaemia in patients without pre‐existing diabetes. Uncontrolled hyperglycaemia was only seen in patients with elevated HbA1c, indicating pre‐existing diabetes.While it is established that the presence of diabetes predisposes to severe clinical forms of COVID‐19, it is yet to be determined if COVID‐19 predisposes to diabetes or adverse glycaemic outcomes.
Tsallis q‐exponentials as atomic orbitals in two‐electron systems
Authors: Lombardo Giuseppe Marcello 
Published: October 2020

AbstractThe use of simple q‐exponential functions, derived from Tsallis entropy distribution, as basis set of atomic orbitals, is explored within the non‐relativistic limit. As compared to Gaussian or to STO (Slater type orbitals) basis set, considering q as variational parameter, q‐exponentials functions lower considerably the energy of two electron systems, always respecting the Ritz variation principle, where E ≥ E0, with E0 being the true energy. The q parameter attains the highest value of 1.209 for Z = 1 (H−) slowly going down toward 1 as Z grows (for Z = 36 q = 1.005225, Kr+34). Interestingly, the correlation energy as determined considering the exact solution by the calculations of Pekeris with the current ones, shows a regular variation as a function of the q parameter. Moreover, the study confirms the link between correlation energy and Shannon information entropy.
An Unsymmetrical Perylene Diimide Dye Modified Carbon Felt Electrode as A Novel Electrochemical Platform for Dopamine Detection
Authors: Varol Tuğba Ören , Avcı Okan , Haklı Özgül , Xue Chenming , Li Quan , Anık Ülkü 
Published: October 2020

AbstractA novel perylene diimide (PDI‐C8SAc) was used as a modifier for carbon felt electrode (CFE) and prepared modified electrode was applied for dopamine detection. Obtained electrochemical current was almost 15‐fold higher compared to plain CFE. Also a cathodic shift in the peak potential was obtained indicating the electrocatalytic effect of the developed sensor. Under optimized experimental conditions, a linear range was observed between 1–100 μM with a limit of detection value of 0.084 μM (n=3). The fabricated sensor was successfully utilized for the dopamine determination in dopamine based medicines.
From substitution to redefinition: A framework of machine learning‐based science assessment
Authors: Zhai Xiaoming , C. Haudek Kevin , Shi Lehong , H. Nehm Ross , Urban‐Lurain Mark 
Published: October 2020

AbstractThis study develops a framework to conceptualize the use and evolution of machine learning (ML) in science assessment. We systematically reviewed 47 studies that applied ML in science assessment and classified them into five categories: (a) constructed response, (b) essay, (c) simulation, (d) educational game, and (e) inter‐discipline. We compared the ML‐based and conventional science assessments and extracted 12 critical characteristics to map three variables in a three‐dimensional framework: construct, functionality, and automaticity. The 12 characteristics used to construct a profile for ML‐based science assessments for each article were further analyzed by a two‐step cluster analysis. The clusters identified for each variable were summarized into four levels to illustrate the evolution of each. We further conducted cluster analysis to identify four classes of assessment across the three variables. Based on the analysis, we conclude that ML has transformed—but not yet redefined—conventional science assessment practice in terms of fundamental purpose, the nature of the science assessment, and the relevant assessment challenges. Along with the three‐dimensional framework, we propose five anticipated trends for incorporating ML in science assessment practice for future studies: addressing developmental cognition, changing the process of educational decision making, personalized science learning, borrowing 'good' to advance 'good', and integrating knowledge from other disciplines into science assessment.
Privacy preserving big data analytics: A critical analysis of state‐of‐the‐art
Authors: Pramanik M. Ileas , Lau Raymond Y. K. , Hossain Md Sakir , Rahoman Md Mizanur , Debnath Sumon Kumar , Rashed Md Golam , Uddin Md Zasim 
Published: October 2020

AbstractIn the era of “big data,” a huge number of people, devices, and sensors are connected via digital networks and the cross‐plays among these entities generate enormous valuable data that facilitate organizations to innovate and grow. However, the data deluge also raises serious privacy concerns which may cause a regulatory backlash and hinder further organizational innovation. To address the challenge of information privacy, researchers have explored privacy‐preserving methodologies in the past two decades. However, a thorough study of privacy preserving big data analytics is missing in existing literature. The main contributions of this article include a systematic evaluation of various privacy preservation approaches and a critical analysis of the state‐of‐the‐art privacy preserving big data analytics methodologies. More specifically, we propose a four‐dimensional framework for analyzing and designing the next generation of privacy preserving big data analytics approaches. Besides, we contribute to pinpoint the potential opportunities and challenges of applying privacy preserving big data analytics to business settings. We provide five recommendations of effectively applying privacy‐preserving big data analytics to businesses. To the best of our knowledge, this is the first systematic study about state‐of‐the‐art in privacy‐preserving big data analytics. The managerial implication of our study is that organizations can apply the results of our critical analysis to strengthen their strategic deployment of big data analytics in business settings, and hence to better leverage big data for sustainable organizational innovation and growth.This article is categorized under:
Commercial, Legal, and Ethical Issues > Security and Privacy
Fundamental Concepts of Data and Knowledge > Big Data Mining
Fundamental Concepts of Data and Knowledge > Data Concepts
Lifting heptagon symbols to functions
Authors: Dixon Lance J. , Liu Yu-Ting 
Published: October 2020

Abstract
Seven-point amplitudes in planar $$ \mathcal{N} $$
N
= 4 super-Yang-Mills theory have previously been constructed through four loops using the Steinmann cluster bootstrap, but only at the level of the symbol. We promote these symbols to actual functions, by specifying their first derivatives and boundary conditions on a particular two-dimensional surface. To do this, we impose branch-cut conditions and construct the entire heptagon function space through weight six. We plot the amplitudes on a few lines in the bulk Euclidean region, and explore the properties of the heptagon function space under the coaction associated with multiple polylogarithms.
Out of the swampland with multifield quintessence?
Authors: Cicoli Michele , Dibitetto Giuseppe , Pedro Francisco G. 
Published: October 2020

Abstract
Multifield models with a curved field space have already been shown to be able to provide viable quintessence models for steep potentials that satisfy swampland bounds. The simplest dynamical systems of this type are obtained by coupling Einstein gravity to two scalar fields with a curved field space. In this paper we study the stability properties of the non-trivial fixed points of this dynamical system for a general functional dependence of the kinetic coupling function and the scalar potential. We find the existence of non-geodesic trajectories with a sharp turning rate in field space which can give rise to late-time cosmic acceleration with no need for flat potentials. In particular, we discuss the properties of the phase diagram of the system and the corresponding time evolution when varying the functional dependence of the kinetic coupling. Interestingly, upon properly tuning the initial conditions of the field values, we find trajectories that can describe the current state of the universe. This could represent a promising avenue to build viable quintessence models out of the swampland if they could be consistently embedded in explicit string constructions.
Distributions of extremal black holes in Calabi-Yau compactifications
Authors: Hulsey George , Kachru Shamit , Yang Sungyeon , Zimet Max 
Published: October 2020

Abstract
We study non-supersymmetric extremal black hole excitations of 4d $$ \mathcal{N} $$
N
= 2 supersymmetric string vacua arising from compactification on Calabi-Yau threefolds. The values of the (vector multiplet) moduli at the black hole horizon are governed by the attractor mechanism. This raises natural questions, such as “what is the distribution of attractor points on moduli space?” and “how many attractor black holes are there with horizon area up to a certain size?” We employ tools developed by Denef and Douglas [1] to answer these questions.
Biosynthetic Resorbable Prosthesis is Useful in Single‐Stage Management of Chronic Mesh Infection After Abdominal Wall Hernia Repair
Authors: Bueno‐Lledó José , Ceno Marsela , Perez‐Alonso Carla , Martinez‐Hoed Jesús , Torregrosa‐Gallud Antonio , Pous‐Serrano Salvador 
Published: October 2020

AbstractBackgroundThe goal of this article was to report the results about the efficacy of treatment of chronic mesh infection (CMI) after abdominal wall hernia repair (AWHR) in one‐stage management, with complete mesh explantation of infected prosthesis and simultaneous reinforcement with a biosynthetic poly‐4‐hydroxybutyrate absorbable (P4HB) mesh.MethodsThis is a retrospective analysis of all patients that needed mesh removal for CMI between September 2016 and January 2019 at a tertiary center. Epidemiological data, hernia characteristics, surgical, and postoperative variables (Clavien–Dindo classification) of these patients were analyzed.ResultsOf the 32 patients who required mesh explantation, 30 received one‐stage management of CMI. In 60% of the patients, abdominal wall reconstruction was necessary after the infected mesh removal: 8 cases (26.6%) were treated with Rives–Stoppa repair, 4 (13.3%) with a fascial plication, 1 (3.3%) with anterior component separation, and 1 (3.3%) with transversus abdominis release to repair hernia defects. Three Lichtenstein (10%) and 1 Nyhus repairs (3.3%) were performed in patients with groin hernias. The most frequent postoperative complications were surgical site occurrences: seroma in 5 (20%) patients, hematoma in 2 (6.6%) patients, and wound infection in 1 (3.3%) patient. During the mean follow‐up of 34.5 months (range 23–46 months), the overall recurrence rate was 3.3%. Persistent, recurrent, or new CMIs were not observed.ConclusionsIn our experience, single‐stage management of CMI with complete removal of infected prosthesis and replacement with a P4HB mesh is feasible with acceptable results in terms of mesh reinfection and hernia recurrence.
Fine-scale rainfall over New Caledonia under climate change
Authors: Dutheil Cyril , Menkes C. , Lengaigne M. , Vialard J. , Peltier A. , Bador M. , Petit X. 
Published: October 2020

AbstractGlobal climate models projections indicate no clear future rainfall changes over the Southwestern Pacific islands in response to anthropogenic forcing. Yet, these models have low (~ 100–200 km) spatial resolution and suffer from large systematic biases, such as the trademark “double ITCZ”. Here, 4 km-resolution simulations were used with a nested regional atmospheric model, which resolves the New Caledonian mountainous topography. The resulting present-day rainfall amount, spatial structure, seasonal cycle, and extremes compare much better with observations than at 20 km resolution. We applied projected changes from global climate models under the RCP8.5 scenario at the boundaries, following an approach that corrects both their present-day and projected sea surface temperature biases. Unlike climate models, our refined projections reveal an 18% decrease in annual mean rainfall over New Caledonia by 2080–2100, especially on the leeward side of the island (up to 30%) and during the hot season (that accounts for ~ 80% of the rainfall decrease). This drying is robust without bias correction, and much stronger than at ~ 20 km resolution. It is mainly driven by circulation changes. A weather regime classification further demonstrates that ~ 80% of the hot season drying relates to a strong anti-cyclonic and air subsidence anomalies centred on the north of NC, which reduces moisture convergence over the archipelago. The frequency and intensity of extreme precipitation events is also reduced by ~ 20% by 2080–2100. This drastic projected drying would have dramatic impacts on water resources and terrestrial ecosystems, pleading for carefully-planned adaptation policies for New Caledonia.
Experiences with the Kono-S anastomosis in Crohn’s disease of the terminal ileum—a cohort study
Authors: Horisberger K. , Birrer D. L. , Rickenbacher A. , Turina M. 
Published: October 2020

Abstract
Purpose
The most frequent long-term complication after ileocecal resection in Crohn’s disease is anastomotic recurrence and subsequent stenosis. Recurrence typically begins at the site of the anastomosis, raising the question of whether the surgical technique of the anastomosis could affect recurrence rates. Kono-S anastomosis is a hand-sewn antimesenteric functional end-to-end anastomosis that offers a wide lumen that is well accessible for endoscopic dilatation. The purpose of our study is to review the rate of postoperative complications almost 2 years after the introduction of this technique.

Materials and methods
This is a prospective single-center cohort study of all consecutive patients with Crohn’s disease undergoing ileocecal resection. Patients’ characteristics as well as specific data for the surgical procedure and short-term outcome were evaluated.

Results
Thirty patients were operated for Crohn’s disease of the terminal ileum (n = 24) or anastomotic recurrence (n = 6). Postoperative complications with a Clavien-Dindo Score ≥ IIIb were observed in three patients. One patient showed a hemorrhage and underwent surgical hemostasis. Two patients developed anastomotic leakage; in both cases, ileostomy was created after resection of the anastomosis. The median hospital stay was 9 days (IQR 7–12). A comparison with a historic group of conventionally operated patients of our hospital revealed no differences in short-term results except for the duration of surgery.

Conclusion
The Kono-S anastomosis is associated with acceptable short-term results, complications, and recurrence rates comparable with the established anastomotic techniques. Longer operation times are observed, but the few published studies concerning long-term recurrence are promising.
Environmental conditions alter successional trajectories on an ephemeral resource: a field experiment with beetles in dead wood
Authors: Vindstad Ole Petter Laksforsmo , Birkemoe Tone , Ims Rolf Anker , Sverdrup-Thygeson Anne 
Published: October 2020

AbstractSuccessional processes can be observed for many organisms and resources, but most studies of succession have focused on plants. A general framework has been proposed, advocating that successional patterns in species turnover are predominantly driven by competition, dispersal or abiotic limitation, and that the patterning of species accumulation over time gives clues to which process is most influential in a given system. We applied this framework to succession in communities of wood-living beetles, utilizing ephemeral resources in the form of 60 experimentally created dead aspen high stumps. High stumps were created at sun-exposed sites (high ambient temperature; favourable abiotic conditions) and shaded sites (low ambient temperature; abiotically limiting conditions). The sites were intermixed, ensuring similar dispersal opportunities. Beetle species richness and abundance were monitored with flight interception traps over four consecutive years. Consistent with predictions from the tested framework, several beetle functional groups accumulated species more slowly at the unfavourable shaded sites than at the favourable exposed sites. Species richness at the exposed sites increased rapidly to a plateau, consistent with a limiting effect of competition on community development. Similar results were obtained for beetle abundance and community structure. Part of the variance in beetle community structure was jointly explained by habitat and fungal community composition, suggesting that differences in the composition and developmental rate of fungal communities in the two habitats contributed to the observed patterns. Targeted experimental studies are now required to decisively establish what processes underlie the contrasting successional trajectories in the two environments.