bluuebunny/crossref_metadata_2025_split huggingface dataset:
RUNOFF SHRINKAGE IN THE WUYUR RIVER BASIN, NORTH‐EAST CHINA, AND ITS INFLUENCE ON THE SUCCESSION OF SALINE MARSH IN THE LOWER REACHES
Authors: Jinming Luo , Fan Yang , Yongjie Wang , Lin Bai , Fugang Liu , Zhiliang Wang 
Published: November 2019

AbstractDrought induced by global climate change and local human disturbance is having a significant impact on the succession of inland saline marshes. This study aims to examine the causes of rapid land degradation in China's Zhalong wetland over the past 65 years (1951–2015) using the Mann–Kendall rank test. Results indicate that local human disturbance (mainly water diversion) is the key detrimental factor in marsh degradation. Water diversion in the upper reaches of the Wuyur river basin has changed the hydrological regime and caused significant water deficit in the Zhalong wetland, thereby leading to rapid shrinkage of the marsh. An increasing runoff trend with an average of 7.44 × 108 m3 was observed in the upper reaches from 1983 to 2015. In contrast, the runoff in the lower reaches had significantly decreased from 8.5 × 108 m3 to 3 × 108 m3 in recent years (P < 0.05), given the water consumed by local anthropogenic activities in the upper reaches. The large water deficit in the lower reaches reduced water storage and caused rapid development of soil sodification, that is, the area of Halaquepts increased from 170 km2 in 1979 to 260 km2 in 2010, in which large areas emerged in the core area of the wetland. Land degradation decreased the habitat of the red‐crowned crane (Grus japonensis). This condition may be an important contributor to the population decline of rare birds and biodiversity loss. © 2019 John Wiley & Sons, Ltd.
Enhanced osteogenesis of honeycomb β‐tricalcium phosphate scaffold by construction of interconnected pore structure: An in vivo study
Authors: Lu Teliang , Feng Shenglei , He Fupo , Ye Jiandong 
Published: November 2019

AbstractPore structure plays an important role in the in vivo osteogenesis for bone repair materials. In this study, honeycomb β‐tricalcium phosphate (β‐TCP) scaffolds were prepared by extrusion method, and gelatin microspheres were used as porogens to modify the pore structure of the scaffolds. The honeycomb β‐TCP scaffolds were characterized by channel‐like square macropores and unidirectional interconnection. To improve the pore interconnectivity of the scaffold, the spherical pores were formed in the channel walls by burning off the gelatin microspheres. Compared with unidirectional honeycomb β‐TCP scaffold, the honeycomb β‐TCP scaffold with interconnected pore structure had significantly higher porosity and faster degradation rate, at the expense of the mechanical strength. The in vivo assessment results demonstrated excellent osteogenesis of the honeycomb scaffolds. Moreover, the honeycomb β‐TCP scaffold with interconnected pore structure markedly promoted new bone formation in comparison with the unidirectional honeycomb β‐TCP scaffold. This work provides a new approach to prepare scaffolds with interconnected pore structure, and the honeycomb β‐TCP scaffold with interconnected pore structure is expected to serve as an efficient bone repair material.
Primary osteoblasts, osteoblast precursor cells or osteoblast‐like cell lines: Which human cell types are (most) suitable for characterizing 45S5‐bioactive glass?
Authors: Wilkesmann Sebastian , Fellenberg Jörg , Nawaz Qaisar , Reible Bruno , Moghaddam Arash , Boccaccini Aldo R. , Westhauser Fabian 
Published: November 2019

AbstractThe question how bioactive glasses (BGs) influence the viability and osteogenic differentiation of human osteogenic cells has already been addressed by several studies. However, a literature review revealed great differences in the type of cells used for these experiments. Primary human osteoblasts (hOBs) represent the desired standard, but possess the limitation of patient variability and time‐consuming isolation protocols. Therefore, several alternative cell types have been used including primary mesenchymal stromal cells (BMSCs) and the “osteoblast‐like” cell lines MG‐63, Saos‐2, HOS, and U2OS. The aim of our study was the identification of the cell type most suitable for tissue engineering projects involving BGs by comparative analysis of cell viability and osteogenic differentiation in response to crystallized 45S5‐BG. We observed that hOBs, BMSCs, and MG‐63 cells were resistant to 45S5‐BG induced cytotoxicity, while the viability of Saos‐2, HOS, and U2OS cells was significantly reduced. In addition, we detected alkaline phosphatase activity, except in U2OS cells, that increased upon 45S5‐BG cocultivation, demonstrating the induction of osteogenic differentiation. Our data and the fact that the donor‐dependent variations can be avoided when using MG‐63 cells suggest that these are a promising alternative to primary cells and remain an important cell line for future BG related studies.
Resveratrol delay the cataract formation against naphthalene‐induced experimental cataract in the albino rats
Authors: Singh Amrita , Bodakhe Surendra H. 
Published: November 2019

AbstractOxidative stress‐induced toxicity plays a major role in ocular diseases such as retinal degeneration, age‐related cataract (ARC) formation and macular dystrophy. In this study, we explored the possible role of resveratrol (RSV) at the different dose levels (10, 20 and 40 mg/kg/day, ip) in an experimental model of naphthalene (1 g/kg/day, po)‐induced age‐related cataracts. Morphological changes in the eyes of the rats in two groups, the RSV and the ARC groups, were monitored weekly, and biochemical parameters in the lenses were assessed after completion of the experimental work. A comparison between the rats in the two groups showed that treatments at RSV doses of 20 and 40 mg/kg/day significantly retarded lenticular opacity, restored antioxidants (CAT, SOD, GPX, GSH), Ca2+ ATPase function, and protein contents, and reduced lipid peroxidation in the lenses of the animals in the RSV group. The treatment with resveratrol at a dose of 10 mg/kg/day did not show any anti‐cataractogenic effects. Based on the results of our investigation, we conclude that supplemental doses of resveratrol at 40 mg/kg/day effectively prevent cataract formation associated with the aging via increased soluble protein contents and Ca2+ homeostasis, apart from the antioxidant restoration. The results demonstrate that RSV treatment may be considered as a promising preventive or supplemental measure for delaying and/or preventing the formation of ARCs.
Annual reporting, agency costs, and firm valuations
Authors: Semenenko Igor , Yoo Junwook 
Published: November 2019

AbstractShareholder valuations are economically significantly and statistically negatively correlated with the length of 10 K filings or their digital file sizes, whereas annual reports posted on corporate websites are uninformative. Firms with longer 10 K filings are likely to experience slower growth, lower profitability, experience free cash flow problems, and write off goodwill and intangible assets from past acquisitions. Lengthy filings are more damaging than suggested by three‐year performance following report filing dates, suggesting that outside investors penalize firms for information asymmetries and associated agency costs. Full disclosure is best from the standpoint of long‐term shareholder wealth, but managers could be maximizing short‐term term returns that better match their investment horizons.
Disclosure, concealment, and dishonesty in psychotherapy: A clinically focused review
Authors: Farber Barry A. 
Published: November 2019

AbstractThis issue of Journal of Clinical Psychology: In Session focuses on the nature and consequences of psychotherapy clients' disclosures, secrets, and dishonesty, with a particular emphasis on the ways in which therapists can best facilitate greater and more honest disclosure. This introduction to this issue reviews the growing theoretical and empirical literature on the frequency, types, motives, and consequences of client and therapist dishonesty (broadly defined); it also reviews the contributions within this issue, noting the welcome focus of the majority of these papers on the nature of client dishonesty in specific disorders (e.g., eating disorders; substance abuse) and/or specific clinical settings (e.g., prisons). Taken together, these papers speak to the ways that therapists may tailor their clinical interventions to match the specific ways that dishonesty manifests in different clinical populations.
The therapist's dilemma: Tell the whole truth?
Authors: Jackson Devlin 
Published: November 2019

AbstractHonest communication between therapist and client is foundational to good psychotherapy. However, while past research has focused on client honesty, the topic of therapist honesty remains almost entirely untouched. Our lab's research seeks to explore the role of therapist honesty, how and why therapists make decisions about when to be completely honest with clients (and when to abstain from telling the whole truth), and the perceived consequences of these decisions. This article reviews findings from our preliminary research, presents a case study of the author's honest disclosure dilemma, and discusses the role of therapeutic tact and its function in the therapeutic process.
Abuse Potential of Lasmiditan: A Phase 1 Randomized, Placebo‐ and Alprazolam‐Controlled Crossover Study
Authors: Wilbraham Darren , Berg Paul H. , Tsai Max , Liffick Emily , Loo Li Shen , Doty Erin Gautier , Sellers Edward 
Published: November 2019

AbstractLasmiditan is a centrally penetrant, highly selective 5‐hydroxytryptamine (serotonin) receptor 1F (5HT1F) agonist under development as a novel therapy for acute treatment of migraine. A phase 1 randomized, placebo‐ and positive‐controlled crossover study assessed the abuse potential of lasmiditan in adult recreational polydrug users. Following a qualification phase, subjects were randomized into treatment sequences, each consisting of 5 study treatments: placebo, alprazolam 2 mg, lasmiditan 100, 200 (lasmiditan 100 and 200 mg are proposed therapeutic doses), and 400 mg (supratherapeutic). The abuse potential of lasmiditan was investigated and compared with alprazolam and with placebo using the maximal effect score (Emax) of the Drug‐Liking Visual Analog Scale as the primary end point. Lasmiditan was not similar to placebo in drug‐liking scores at all doses tested, with a maximum difference observed with the lasmiditan 400‐mg dose (upper 90% confidence limit on difference in least‐squares [LS] means > 14 for all lasmiditan doses). Drug‐liking scores for lasmiditan 400 mg were not significantly different from alprazolam (lower 90% confidence limit on difference in LS means < 5), but drug‐liking scores at lower doses (100 and 200 mg) were significantly different from alprazolam. During the treatment phase, the incidence of treatment‐emergent adverse events (TEAEs) increased with increasing dose of lasmiditan; all TEAEs reported with lasmiditan treatment were mild. Subjective drug‐liking effects for lasmiditan versus placebo and versus alprazolam, and the safety and tolerability profile of lasmiditan suggest that lasmiditan has a low potential for abuse.
Toxicity of azoles towards the anaerobic ammonium oxidation (anammox) process
Authors: Lakhey Nivrutti , Li Guangbin , Sierra‐Alvarez Reyes , Field Jim A 
Published: November 2019

AbstractBACKGROUNDAzoles are an important class of compounds that are widely used as corrosion inhibitors in aircraft de‐icing agents, cooling towers, semiconductor manufacturing and household dishwashing detergents. They also are important moieties in pharmaceutical drugs and fungicides. Azoles are widespread emerging contaminants occurring frequently in water bodies. Azole compounds can potentially cause inhibition towards key biological processes in natural ecosystems and wastewater treatment processes. Of particular concern is the inhibition of azoles to the nitrification process (aerobic oxidation of ammonium). This study investigated the acute toxicity of azole compounds towards the anaerobic ammonia oxidation (anammox) process, which is an important environmental biotechnology gaining traction for nutrient‐nitrogen removal during wastewater treatment. In this study, using batch bioassay techniques, the anammox toxicity of eight commonly occurring azole compounds was evaluated.RESULTSThe results show that 1H‐benzotriazole and 5‐methyl‐1H‐benzotriazole had the highest inhibitory effect on the anammox process, causing 50% decrease in anammox activity (IC50) at concentrations of 19.6 and 17.8 mg L−1, respectively. 1H‐imidazole caused less severe toxicity with an IC50 of 79.4 mg L−1. The other azole compounds were either nontoxic (1H‐pyrazole, 1H‐1,2,4‐triazole and 1‐methyl‐pyrazole) or at best mildly toxic (1H‐benzotriazole‐5‐carboxylic acid and 3,5‐dimethyl‐1H‐pyrazole) towards the anammox bacteria at the concentrations tested.CONCLUSIONSThis study showed that most azole compounds tested displayed mild to low or no toxicity towards the anammox bacteria. The anammox bacteria were found to be far less sensitive to azoles compared to nitrifying bacteria. © 2019 Society of Chemical Industry
HIV viral resuppression following an elevated viral load: a systematic review and meta‐analysis
Authors: Ford Nathan , Orrell Catherine , Shubber Zara , Apollo Tsitsi , Vojnov Lara 
Published: November 2019

AbstractIntroductionGuidelines for antiretroviral therapy recommend enhanced adherence counselling be provided to individuals with an initial elevated viral load before making a decision whether to switch antiretroviral regimen. We undertook this systematic review to estimate the proportion of patients with an initial elevated viral load who resuppress following enhanced adherence counselling.MethodsTwo databases and two conference abstract sites were searched from January 2012 to October 2019 for studies reporting the number of patients with an elevated viral load whose viral load was undetectable when subsequently assessed. Data were pooled using random effects meta‐analysis.ResultsFifty‐eight studies reported outcomes of 45,720 viraemic patients, mostly from Africa (48 studies), and among patients on first‐line antiretroviral therapy (43 studies). Almost half (46.1%, 95% CI 42.6% to 49.5%) of patients with an initial elevated viral load resuppressed following an enhanced adherence intervention. Of those on first‐line ART with confirmed virological failure (6280 patients, 21 studies), only 53.4% (40.1% to 66.8%) were appropriately switched to a different regimen. Resuppression was higher among studies that provided details of adherence support. The proportion resuppressing was lower among children (31.2%, 21.1% to 41.3%) and adolescents (40.4%, 15.7% to 65.2%) compared to adults (50.4%, 42.6% to 58.3%). No important differences were observed by date of study publication, gender, viral failure threshold, publication status, time between viral loads or treatment regimen. Information on resistance testing among people with an elevated viral load was inconsistently reported.ConclusionsThe findings of this review suggest that in settings with limited resources, current guideline recommendations to provide enhanced adherence counselling can result in resuppression of a substantial number of these patients, avoiding unnecessary drug regimen changes. Appropriate action on viral load results is limited across a range of settings, highlighting the importance of viral load cascade analyses to identify gaps and focus quality improvement to ensure that action is taken on the results of viral load testing.
Inborn errors of metabolism leading to neuronal migration defects
Authors: Schiller Stina , Rosewich Hendrik , Grünewald Stephanie , Gärtner Jutta 
Published: November 2019

AbstractThe development and organisation of the human brain start in the embryonic stage and is a highly complex orchestrated process. It depends on series of cellular mechanisms that are precisely regulated by multiple proteins, signalling pathways and non‐protein‐coding genes. A crucial process during cerebral cortex development is the migration of nascent neuronal cells to their appropriate positions and their associated differentiation into layer‐specific neurons. Neuronal migration defects (NMD) comprise a heterogeneous group of neurodevelopmental disorders including monogenetic disorders and residual syndromes due to damaging factors during prenatal development like infections, maternal diabetes mellitus or phenylketonuria, trauma, and drug use. Multifactorial causes are also possible. Classification into lissencephaly, polymicrogyria, schizencephaly, and neuronal heterotopia is based on the visible morphologic cortex anomalies. Characteristic clinical features of NMDs are severe psychomotor developmental delay, severe intellectual disability, intractable epilepsy, and dysmorphisms. Neurometabolic disorders only form a small subgroup within the large group of NMDs. The prototypes are peroxisomal biogenesis disorders, peroxisomal ß‐oxidation defects and congenital disorders of O‐glycosylation. The rapid evolution of biotechnology has resulted in an ongoing identification of metabolic and non‐metabolic disease genes for NMDs. Nevertheless, we are far away from understanding the specific role of cortical genes and metabolites on spatial and temporal regulation of human cortex development and associated malformations. This limited understanding of the pathogenesis hinders the attempt for therapeutic approaches. In this article, we provide an overview of the most important cortical malformations and potential underlying neurometabolic disorders.
Role of Breast MRI in the Evaluation and Detection of DCIS: Opportunities and Challenges
Authors: Greenwood Heather I. , Wilmes Lisa J. , Kelil Tatiana , Joe Bonnie N. 
Published: November 2019

Historically, breast magnetic resonance imaging (MRI) was not considered an effective modality in the evaluation of ductal carcinoma in situ (DCIS). Over the past decade this has changed, with studies demonstrating that MRI is the most sensitive imaging tool for detection of all grades of DCIS. It has been suggested that not only is breast MRI the most sensitive imaging tool for detection but it may also detect the most clinically relevant DCIS lesions. The role and outcomes of MRI in the preoperative setting for patients with DCIS remains controversial; however, several studies have shown benefit in the preoperative evaluation of extent of disease as well as predicting an underlying invasive component. The most common presentation of DCIS on MRI is nonmass enhancement (NME) in a linear or segmental distribution pattern. Maximizing breast MRI spatial resolution is therefore beneficial, given the frequent presentation of DCIS as NME on MRI. Emerging MRI techniques, such as diffusion‐weighted imaging (DWI), have shown promising potential to discriminate DCIS from benign and invasive lesions. Future opportunities including advanced imaging visual techniques, radiomics/radiogenomics, and machine learning / artificial intelligence may also be applicable to the detection and treatment of DCIS.Level of Evidence: 3Technical Efficacy Stage: 3J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;52:697–709.
Exploring the Effect of Perceived Teacher Support on Multiple Creativity Tasks: Based on the Expectancy–Value Model of Achievement Motivation
Authors: Sun Cuicui , Zhou Zhijin , Yu Quanlei , Gong Shaoying , Yi Liu , Cao Yang 
Published: November 2019

AbstractThe present study explores the effect of perceived teacher support on three forms of thinking related to creativity. Tests of convergent thinking (by means of the Remote Associates Test), insight thinking (explored through a brain‐teaser test), and divergent thinking (by means of a verbal creativity test) were given to 512 middle school students in China, along with assessments of their perceived teacher support and creative self‐efficacy. The results of this study indicate that perceived teacher support positively predicts convergent thinking and insight thinking, with creative self‐efficacy playing a partial mediating role between perceived teacher support and convergent thinking. However, no significant relationships were found between perceived teacher support and divergent thinking. The findings partly lend support to the expectancy–value model of achievement motivation that teacher’s behavior influences student performance through self‐belief pathway.
Raman imaging of residual stress distribution in epoxy resin and metal interface
Authors: Abiko Katsutoshi , Kato Yuichi , Hohjo Hiroshi , Kishida Yoshihiro , Sudo Eiichi 
Published: November 2019

AbstractA method for the distribution analysis of residual stress in epoxy resins by Raman microspectroscopy was developed. By using the uniaxial tensile method, a negative correlation between the peak shift of the aromatic C─H stretching vibration and external stress was obtained. By optimizing the precision of the Raman shift measurement, a reliable stress image was obtained for a bulk epoxy resin. This method was applied to the evaluation of the residual stress distribution in epoxy resin/aluminum bonded materials. Raman spectra imaging revealed that stress concentration strongly occurred in the interface of the cured epoxy resin with aluminum, and it was found that Raman spectra images of the small residual stress of the resin interface were affected by the curing process and physical properties of the epoxy resin. Therefore, Raman spectra imaging would appear to have significant potential as a technique for the evaluation of local thermal residual stress in the interface of multimaterial structures.
Kinetics of wet air oxidation of sodium sulfide over heterogeneous iron catalyst
Authors: Barge Aditti S. , Vaidya Prakash D. 
Published: November 2019

AbstractWet air oxidation (WAO) is an established technique for reducing the chemical oxygen demand (COD) of refinery sulfidic spent caustic waste. In the present work, the heterogeneous form of the cheap and abundant catalyst ferrous sulfate (FeSO4) was employed for WAO of sodium sulfide. The performance of this catalyst in the oxidative destruction of this model compound is thus far unfamiliar. Kinetic data for the non‐catalytic and catalytic oxidation processes was collected in a batch reactor. For the catalytic process, temperature (T), oxygen partial pressure () and catalyst concentration (ω) were varied in the ranges 80‐150°C, 0.69‐2.06 MPa and 0.8‐2.4 g/L respectively. Around 94% COD was destroyed within 1 h when feed containing 8 g/L of sulfide was oxidized at T = 100°C, = 0.69 MPa, and ω = 0.8 g/L. First, the data on disappearance of COD were fitted to a power law model and reaction rate constants were determined. The activation energy for the non‐catalytic (91 kJ/mol) and catalytic (50 kJ/mol) oxidation process was found from the temperature dependence of the rate constants. Second, hyperbolic models based on Langmuir‐Hinshelwood (L‐H) and Eley‐Rideal (E‐L) kinetics were used for fitting kinetic data. It was found that the L‐H model suggesting dissociative adsorption of oxygen provided the best fit. In this way, a deep insight into oxidation kinetics of sodium sulfide was provided.