bluuebunny/crossref_metadata_2025_split huggingface dataset:
TEORIJSKI I PRAKTIČNI ZNAČAJ SLOŽENIH MODELA ZASNOVANIH NA ANALIZAMA MODERACIJE I MEDIJACIJE
Authors: Lazić Milica M. 
Published: December 2020

Most statistical methods applied in the social sciences involve testing direct relationships among variables. However, since psychology deals with complex phenomena, this corpus of methods is not sufficient to understand the mechanisms and conditions under which certain direct relationships apply. Moderation and mediation analyzes were the first step towards understanding the more complex relationships among variables. The analysis of mediation answers the question of “how” and “why”, or through what mechanisms a particular relation is realized, while the analysis of moderation offers the answer to the question of “when”, “for whom” and “under what conditions” a particular relation between the predictor and criterion variables applies. Although the increasing use of moderation and mediation analyzes has led to advances in understanding the phenomena addressed by psychology, complex psychological theories require testing more complex models based on these analyzes. Accordingly, this paper will outline theoretical rationales for using models such as moderated mediation, moderation mediation, parallel and serial mediation, three-way interaction, and nonlinear moderation. This paper focuses on explaining the conceptual differences between these complex models, through demonstrating the need to use these models on examples of different psychological theories.
Integration Strategy of Marketing and Supply Chain PT Semen Indonesia (Persero) Tbk. Holding Company
Authors: Zulkarnain Deki , Wahyudi Edy , Sasongko Sasongko 
Published: December 2020

AbstractThis research focuses on exploring the marketing and supply chain integration strategy at PT Semen Indonesia (Persero) Tbk. Holding Company. The status of the state-owned enterprise (SOE) cement industry has dominated the cement market share in Indonesia after the holding strategy, but the data shows that the market share of Semen Indonesia sales has continued to decline. Another problem is that the accumulated cost of revenue has increased sharply, especially since the income growth is not significant, so that gross income has decreased. This research presents integration activities that occur at the corporate and functional level in the marketing and supply chain directorates. The case study method is used in this research to track the integration of marketing and supply chains as an effort to improve the company's sales performance. Data was collected through in-depth interviews in the Marketing Research & Analysis section of PT Semen Indonesia (Persero) Tbk and secondary data in the form of company annual reports. The results of this study indicate that PT Semen Indonesia (Persero) Tbk integrates marketing and its supply chain through a strategy of unifying the two functions in one directorate. The marketing and supply chain functions at each Operating holding have been revoked, all of them directly managed by the Holding Company. The supply chain is centrally integrated in the form of transportation, distribution and procurement functions. In the marketing aspect, the Holding Company integrates the marketing planning and marketing control and marketing functions as well as the sales function.
Keywords: Strategy; Integration; Marketing; Supply Chain; Holding Company
Combining 10% propolis with carbonated hydroxyapatite to observe the RANKL expression in a rabbit’s alveolar bone
Authors: Devitaningtyas Nungky , Syaify Ahmad , Herawati Dahlia 
Published: December 2020

Background: Periodontitis causes an increased receptor activator level in the nuclear factor-κβ ligand (RANKL), which is one of the inflammatory mediators that plays a role in osteoclastogenesis. The open flap debridement (OFD) technique is the preferred treatment when accompanied by regenerative periodontal treatment using guided tissue regeneration (GTR) and guided bone regeneration (GBR). Carbonated hydroxyapatite is a GBR material that serves as a scaffold and has strong osteoconductive properties for bone regeneration. Propolis is natural product that can decrease osteoclastogenesis in periodontitis by decreasing the RANKL expression. Purpose: To investigate the RANKL expression after open flap debridement by applying carbonated hydroxyapatite to 10% propolis in the alveolar bone of rabbits. Methods: Nine induced-periodontitis rabbits (Oryctolagus cuniculus) were divided into three treatment groups of Group A OFD, Group B OFD followed by the application of carbonated hydroxyapatite, and Group C OFD followed by application of 10% propolis-carbonated hydroxyapatite. Each group was selected one to euthanised on the seventh, 14th and 28th day, respectively, and prepared using histology slides. The data was analysed using a two-way ANOVA followed by a post-hoc LSD test (p<0.05). Results: The RANKL expression in each group showed significant differences (p=0.00; p<0.05) on the seventh, 14th and 28th day. The post-hoc LSD test showed that the RANKL expression in the treatment group with carbonated hydroxyapatite-10% propolis had significant differences (p<0.05) in the intergroup analysis at different time points. Conclusion: Combining 10% propolis with carbonated hydroxyapatite in OFD treatment can decrease the RANKL expression in a rabbit’s alveolar bone.
Role of Immune Response and Some Microbial Agents in Atopic Dermatitis Pathogenicity and Management
Authors: Suzan Yousif Jasim  , Mayssaa E. Abdalah  , Bahir Abdul Razzaq Mshimesh  
Published: December 2020

Atopic dermatitis is a disease characterized by chronic inflammation, exhibiting its effects on a large number of children and adults. This disease results from many factors like defects in skin barrier, immunological, genetic and environmental factors. In addition to these factors, the presence of microorganisms on the skin surface of the patients, like Staphylococcus aureus, play important role in exacerbating the chronic inflammation. Atopic dermatitis patients exhibit defects in immune responses, which in turn increase the susceptibility to infections (bacterial, fungal and viral), so the presence of bacterium or its toxin lead to exacerbate the activity of the disease by stimulating the immune cells like Th-2 cells and eosinophils, in addition to activate the production of toxin-specific IgE. The relationship among atopic dermatitis, immune response and microbial infection, especially S. aureus, is incompletely understood. The current review aims to help the researchers within immunologic and dermatologic fields through shedding a light on the role of immune response and some microbial agents on the pathogenicity of atopic dermatitis.
Carriage of Antibiotic Resistant Biofilm Producing Bacteria on Mobile Phones Used By Health Care Professionals (HCP) in a Hospital in Ras Al Khaimah, UAE
Authors: Soniya Shivani  , Osman Ahmed  , Michael Magaogao  , Hafiz Ahmad  , Ashfaque Hossain  
Published: December 2020

Cell phones are the most common gadgets used in today’s world. Studies from different countries demonstrated that these electronic gadgets can carry different bacterial species, including potential pathogenic strains. These gadgets are in the hands of every health care professionals (HCPs) and can even be found in the operation theatres (OT). Moreover, healthcare workers tend to neglect the potential infectious threat that these gadgets carry. Hence, we investigated the microbial profile present on cell phones used by HCPs in United Arab Emirates (UAE). Standard microbiological procedures were used for collection and identification of bacterial species. Disk diffusion assay and crystal violet dye binding spectrophotometric assay were used for determining antibiogram and biofilm forming potential, respectively. Staphylococcus epidermidis was present in 64.1% of the samples, followed by Micrococci (22.3%), Streptococcus viridians (2.2%), Diphtheroids (2.9%), Bacillus spp. (5.2%), Enterobacter spp. (1.4%) and Pseudomonas spp. (1.4%). The tested strains exhibited varied degree of antibiotic resistance and biofilm producing potential. Our data highlights that mobile phones may just not be carriers for normal skin flora but also for antibiotic resistant, biofilm forming potential opportunistic pathogens and thus may serve as transmission vectors for bacteria. This is the first report from UAE analyzing carriage of bacteria in mobile gadgets used by HCPs. Furthermore, this would help to raise awareness among the HCPs about these electronic gadgets serving as a vehicle of transmission of bacterial pathogen.
Demographic, Comorbidity, and Episode-of-Care Differences in Primary Total Knee Arthroplasty
Authors: Siddiqi Ahmed , Warren Jared A. , McLaughlin John , Kamath Atul F. , Krebs Viktor E. , Molloy Robert M. , Piuzzi Nicolas S. 
Published: December 2020

Background:
Understanding time trends in age, demographic characteristics, and comorbidities is especially critical to highlight the effects on clinical practice change, outcomes, and the value of total knee arthroplasty (TKA). Therefore, the purpose of this study was to identify trends in the demographic characteristics, comorbidities, and episode-of-care outcomes for patients who underwent TKA from 2008 to 2018.

Methods:
The National Surgical Quality Improvement Program (NSQIP) was queried to identify patient demographic characteristics, comorbidities, and episode-of-care outcomes in patients who underwent primary TKA from 2008 to 2018 (n = 350,879). Trends for continuous variables were analyzed using analysis of variance, and categorical variables were analyzed using chi-square tests.

Results:
From 2008 to 2018, there was no clinically important difference in age, body mass index (BMI), and percentage of patients with BMI of >40 kg/m2 and no clinically important difference in chronic obstructive pulmonary disease (3.5% in 2008 and 3.2% in 2018), congestive heart failure within 30 days (0.3% in both 2008 and 2018), and acute renal failure (0.1% in 2008 and <0.1% in 2018) among patients undergoing TKA. However, modifiable comorbidities, including smoking status (9.5% in 2008 and 7.7% in 2018; p < 0.001), hypertension (71.0% in 2008 and 63.7% in 2018; p < 0.001), and anemia (16.2% in 2008 and 9.7% in 2018; p < 0.001), functional status, and overall morbidity and mortality probability have improved, with no clinically important difference in the percentage of diabetes (19.0% in 2008 and 18.1% in 2018). The hospital length of stay (mean [and standard deviation], 3.8 ± 2.2 days in 2008 and 2.1 ± 2.0 days in 2018; p < 0.001) and 30-day readmission (4.6% in 2011 and 3.0% in 2018; p < 0.001) decreased, with a significant increase in home discharge (65.6% in 2011 and 87.8% in 2018; p < 0.001).

Conclusions:
The overall patient health status improved from 2008 to 2018, with improvement in the modifiable comorbidities of smoking status, malnutrition, hypertension, and anemia; the functional status; and the overall morbidity and mortality probability, with no clinically relevant change in patient age; patient BMI; percentage of patients with BMI of >40 kg/m2; or patients with diabetes mellitus, chronic obstructive pulmonary disease, congestive heart failure within 30 days, or acute renal failure. Our findings may be a reflection of a global shift toward value-based care focusing on patient optimization prior to arthroplasty, quality of care, and improved outcomes. The results of our study highlight the potential increase in TKA procedural value, which is paramount for health-care policy changes in today’s incentivized, value-based, health-care environment.
Elastic Intramedullary Nailing of Pediatric Both-Bone Forearm Fractures
Authors: Upasani Vidyadhar V. , Li Ying 
Published: December 2020

Background:
Elastic intramedullary nailing of both-bone pediatric forearm fractures is used to treat unstable fractures that fail conservative management with closed reduction and casting, open injuries, or injuries with neurovascular compromise.

Description:
Small incisions are used to enter the medullary canal of the distal end of the radius and proximal part of the ulna, avoiding injury to the adjacent physis. The elastic nail is advanced to the fracture site under fluoroscopic guidance. The fracture is reduced with traction and manipulation, and the nail is passed across the fracture site to stabilize the forearm.

Alternatives:
Closed reduction and casting is the mainstay of treatment in most pediatric forearm fractures. If conservative treatment fails, these fractures can be surgically managed with elastic intramedullary nails or with plate and screw fixation.

Rationale:
Elastic intramedullary nailing of pediatric forearm fractures provides a minimally invasive alternative to treat unstable fractures that fail closed reduction and casting. It has been shown to be a reliable method of achieving anatomic union with excellent function of the injured upper extremity in most patients with very few complications related to the surgery
1–3
.

Expected Outcomes:
We advise patients that in >90% of children treated with this technique, we achieve anatomic union with excellent wrist and elbow function. Usually, the nails can be removed 6 to 12 months after the procedure. Complications related to infection, nonunion, malunion, compartment syndrome, and neurovascular compromise are rare
1–3
.

Important Tips:

Position the patient and fluoroscopy machine to allow easy access to the elbow and wrist throughout the procedure.Use a sharp-pointed awl to access the medullary canal without injuring the adjacent physes of the distal end of the radius or proximal part of the ulna.Contour the radial implant to allow easy passage and to establish the anatomic radial bow.Traction and direct manual pressure can be used to reduce the fractured fragments to allow passage of the implants across the fracture site.A small open reduction of the fracture site should be performed after ≥3 failed attempts at obtaining a closed reduction.The nails should be cut so that they can be buried subcutaneously but easily accessed for later removal without injuring the adjacent physes.
Apakah Kinerja Lingkungan dan Biaya Lingkungan Berpengaruh Terhadap Pengungkapan Informasi Lingkungan?
Authors: Adyaksana Rahandhika Ivan , Pronosokodewo Baniady Gennody 
Published: December 2020

Environmental information disclosure is one type of disclosure that is still voluntary. Only a few manufacturing companies in Indonesia have disclosed environmental information. This study aims to determine the effect of environmental performance and environmental costs on environmental information disclosure. The population of this research is all manufacturing companies in Indonesia from 2014-2018. This study uses secondary data with sample selection using purposive sampling method. The data obtained were 20 companies and processed using SPSS software with multiple linear tests. The results showed that environmental performance had a positive and significant effect on environmental information disclosure. Meanwhile, environmental costs have no effect on environmental information disclosure. The implication of this research is that companies that already have good environmental performance and already have an efficient environmental cost are willing to disclose environmental information continuously even though they are still voluntary.
Strong Association of Glaucoma with Atherosclerosis and Potential Therapeutic Effect of Methazolamide on Atherosclerosis
Authors: Song XianQin , Li Peng , Yuan Lin , Li Yunfeng , Yan Xinfeng , Zhao Cong , An Yi , Chang XiaoTian 
Published: December 2020

Abstract
Carbonic anhydrases (CAs) catalyze the synthesis of HCO3− from H2O and CO2. The dysfunction of CAs leads to aqueous humor secretion and high intraocular pressure to cause glaucoma pathogenesis. Methazolamide (MTZ), a CA inhibitor, can effectively treat glaucoma by reducing aqueous humor secretion. We previously reported that carbonic anhydrase I (CA1), a CA family member, was highly expressed in atherosclerotic tissues of the aorta and stimulated atherosclerosis (AS) by promoting calcification. MTZ showed therapeutic and preventive effects on AS in a mouse model. The above findings suggest a relationship between AS and glaucoma. This study explored the possible association between AS prevalence and glaucoma prevalence and the therapeutic effect of MTZ on AS by analyzing medical records. Among 10751 patients with a primary diagnosis of glaucoma, 699 (6.5%) were also diagnosed with AS. However, the incidence of AS in patients with keratitis and scleritis, which are ophthalmic diseases, was 2.5% (206/8383 patients) and 3.5% (46/1308 patients), respectively. In the population without ophthalmic records, the AS prevalence was only 1.9% (99416/5168481 patients). Among 152425 patients with a primary diagnosis of AS, 1245 (0.82%) were also diagnosed with glaucoma. Among 199782 patients with a primary diagnosis of hypertension (excluding AS), 1149 (5.7‰) were diagnosed with glaucoma, and among 5313433 patients without AS or hypertension, 9513 (1.8‰) were diagnosed with glaucoma. Our study also found that AS patients with glaucoma were more likely to suffer from angle-closure glaucoma, Additionally, Among 14 patients who suffered from both AS and glaucoma and were treated with MTZ to cure their glaucoma, 9 people showed reduced low-density lipoprotein (LDL) levels, the main index of AS, within 3 months after medication use (2.81 ± 0.61 mmol/L VS 2.38 ± 0.58 mmol/L, p = 0.039). The above findings show a strong relation between AS and glaucoma and support that MTZ can be considered a potential therapy to treat AS.
Multi-UAV Path Planning Methodology for Postdisaster Building Damage Surveying
Authors: Nagasawa Ryosuke , Mas Erick , Moya Luis , Koshimura Shunichi 
Published: December 2020

Abstract
For effective disaster relief decision-making, responders require extensive and rapid information on the damage situation in affected areas. Areas with unknown conditions pose a high risk of injury, and working on the ground limits the coverage and speed of information acquisition. An alternative is to exploit aerial observations and, in particular, unmanned aerial vehicles (UAVs). UAVs can be rapidly deployed to access remote areas without risking survey teams. Moreover, large-scale disasters impact wide areas, and multiple UAVs are needed to increase coverage without compromising resolution or speed. Of particular importance for evaluation are assets such as hospitals, shelters and essential infrastructures. UAVs can survey such structures to construct three-dimensional (3D) models for inspection.A structure-from-motion (SfM) survey generates 3D models from multiple images. However, most path planning algorithms for SfM focus on points of interest taken from an individual UAV and consider a single structure. Here, we propose a path design method for multi-UAV SfM surveys. By designing flight paths with sufficient overlap and sidelap ratios for all faces of the surveyed objects, more precise 3D models can be constructed than with conventional methods. The fuzzy C-means method is adopted to reduce the UAV flight loads to a uniform minimum to ensure full battery utilization.
WITHDRAWN: Economic Burden of Non-Alcoholic Steatohepatitis with Significant Fibrosis in Thailand
Authors: Phisalprapa Pochamana , Prasitwarachot Ratthanon , Kositamongkol Chayanis , Hengswat Pranaidej , Srivanichak Weerachai , Washirasaksiri Chaiwat , Treeprasertsuk Sombat , Charatcharoenwitthaya Phunchai , Chaiyakunapruk Nathorn 
Published: December 2020

Abstract
Background: Non-alcoholic steatohepatitis (NASH) has been recognised as a significant form of chronic liver disease and a common cause of cirrhosis and hepatocellular carcinoma, resulting in a considerable financial burden on healthcare resources. Currently, there is no information regarding the economic burden of NASH in low- and middle-income countries (LMICs). The aim of this study was to estimate the economic burden of NASH in Thailand as a lesson learned for LMICs.Methods: To estimate the healthcare costs and prevalence of NASH with significant fibrosis (fibrosis stage ≥ 2) in the general Thai population, an eleven-state lifetime horizon Markov model with 1-year cycle length was performed. The model comprised Thai population aged 18 years and older. The cohort size was based on Thailand Official Statistic Registration Systems. The incidence of NASH, transitional probabilities, and costs-of-illness were based on previously published literature, including systematic reviews and meta-analyses. The age-specific prevalence of NASH was based on Thai NASH registry data. Costs were expressed in 2019 US Dollars ($). As we undertook analysis from the payer perspective, only direct medical costs were included. All future costs were discounted at an annual rate of 3%. A series of sensitivity analyses were performed.Results: The estimated total number of patients with significant NASH was 2.9 million cases in 2019, based on a NASH prevalence of 5.74%. The total lifetime cost of significant NASH was $15.2 billion ($5,147 per case), representing approximately 3% of the 2019 GDP of Thailand. The probabilistic sensitivity analysis showed that the lifetime costs of significant NASH varied from $11.4 billion to $18.2 billion.Conclusions: The economic burden associated with NASH is substantial in Thailand. This prompts clinicians and policy makers to consider strategies for NASH prevention and management.
Effect of Sodium Selenite, Selenium Yeast, and Bacterial Enriched Protein on Egg Yolk Colour, Antioxidant Profiles and Oxidative Stability
Authors: Muhammad Aliyu , Muhammad Daliah , Loh Teck , Akit Henny , Samsudin Anjas Asmara 
Published: December 2020

Abstract
Background: The chicken egg is one of the nature’s flawlessly preserved biological products, recognized as an excellent source of nutrients for humans. Selenium (Se) is an essential micro-element that plays a key role in biological processes. Organic Se sources have shown many advantages over inorganic Se in poultry and can be produced biologically by microbial reduction of Se. Therefore, the possibility of integrating Se enriched bacteria as a supplement in poultry feed can provide an interesting source of organic Se, thereby increase egg Se concentration, improve oxidative stability and offer health-related advantages to humans. The objective of this study was to examine the effects inorganic and different organic Se sources on egg yolk colour, antioxidant profile, oxidative stability, and storage effect in relation to the treatments for fresh and stored egg yolk at 4±2 0C for 14 days. Results: The results reveals that dietary Se supplementation, especially the organic (ADS18 > Se-Yeast) sources influence (p < 0.05) egg yolk colour. Dietary inorganic Se and organic Se were noted to significantly improves egg yolk and breast meat antioxidants profile (total carotenoid and phenol content). There was a significant (p < 0.05) decrease in total cholesterol in fresh, stored egg yolk and breast muscle of Se treated groups compared with control. Whereas for breast muscle, only hens with organic Se supplementation (ADS18 > Se-Yeast) showed lower (p < 0.05) cholesterol compared to inorganic and control hens. The oxidative stability parameters of the eggs, breast and thigh muscle, and plasma showed a significant decrease (p < 0.05) in primary oxidation products (MDA) concentrations with hens supplemented with ADS18. However, the MDA content increased (p < 0.05) with an advanced storage period in egg yolk. It should be noted that, compared to inorganic Se and basal diets, egg yolk from hens fed with organic Se remain fresh for 2 weeks.Conclusions: Dietary Se organic supplementation (ADS18 > Se-Yeast) improves egg yolk colour, antioxidant profile, and oxidative status of egg yolk and tissue. For egg enrichment and antioxidant properties, the source of supplemented organic Se is essential. Thus, ‘’functional eggs’’ enriched with organic selenium becomes possible to produced.