bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scepter XC Balloon Angioplasty for Vasospasm Following Ruptured Aneurysm: Single-Center Experience and Results
Authors: Chen Chun-Ting , Chen Ching-Chang , Wang Alvin Yi-Chou , Wu Yi-Ming , Chin Shy-Chyi , Hsieh Po-Chuan , Yeap Mun-Chun , Hsu Shih-Yuan , Lin Ya-Jui 
Published: March 2020

Abstract
Background: Cerebral vasospasm still results in high morbidity and mortality rates in patients after aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to establish a protocol for the management of vasospasm and demonstrate our experience of angioplasty using the Scepter XC balloon catheter. Methods: An image survey was arranged if early symptomatic vasospasm occurred, or on the 7th day following aneurysmal SAH. In patients with clear consciousness, balloon angioplasties were performed for symptomatic vasospasms, which were not improved within 6-12 hours after maximal medical treatments. In unconscious patients, balloon angioplasties were performed for all patients with angiographic vasospasms. We retrospectively reviewed clinical findings, radiological results, and functional outcomes for these patients. Results: Fifty patients underwent Scepter XC balloon angioplasty among 396 consecutive patients who accepted endovascular or surgical treatments for ruptured aneurysms. All angioplasty procedures were successful without complications. 100% angiographic improvement and 94% clinical improvement were reached immediately after the angioplasties. A favorable functional outcome (modified Rankin Score of ≤2) could be achieved in 82% of patients. Even in patients with poor clinical grading (Hunt–Hess grade 4–5), a clinical improvement rate of 87.5% and favorable functional outcome rate of 70.8% could still be achieved. Conclusion: Balloon angioplasty with Scepter XC balloon catheter is safe and effective for post-SAH vasospasm. This device’s extra-compliant characteristics could considerably improve the quality of angioplasty procedures. For all patients, even those with poor neurological status, aggressive evaluation and early treatment of vasospasm can noticeably improve clinical outcomes.
Comparative Transcriptome Analysis Uncovers Genes and Pathways Relating to Downy Mildew Resistance in Isabgol (Plantago ovata Forsk.)
Authors: Ponnuchamy Manivel , Patel Sandip , Mathew Jincy , Kumar Jitendra , Reddy Nagaraja Reddy Rama 
Published: March 2020

Abstract
BackgroundIsabgol (Plantago ovata Forsk.) downy mildew (DM), caused by obligate oomycete pathogen Peronospora plantaginis Underwood., is the single most damaging disease of Isabgol. However, reports on the genes and pathways involved in mediating resistance are still unknown.ResultsIn the present study, transcriptomic analysis was carried out by next generation sequencing of DM infected and uninfected leaves of resistant and susceptible genotypes to understand the genetic mechanisms underlie the host-plant resistance. A total of 33.47 million reads were generated and de novo assembled and annotated. The assembly using Trinity yielded 38803, 40175, 45451 and 39533 non-redundant transcript contigs, respectively in susceptible infected, Susceptible uninfected, Resistant infected and resistant uninfected samples. More than 90% of coding DNA sequence (CDS) predicted were annotated using BLAST search. Isabgol transcriptome showed the highest similarity to Sesamum indicum (41-59%) followed by Erythranthe guttata (10-13%). Putative CDS encoding Pathogen associated Molecular Pattern (PAMP)-triggered immunity (PTI), Effector-Triggered Immunity (ETI), Cell wall degrading enzymes, Phytohormone signalling and Phenylpropanoid biosynthesis pathways involved in host-pathogen interaction were identified in addition to the identification of several candidate resistance (R) genes enriched in response to DM infection. We identified significantly differentially expressed genes (DEGs) genes; 6928 DEGs in resistant uninfected (RU) vs resistant infected (RI) of DPO-185 (resistant) genotype and 8779 susceptible uninfected (SU) vs susceptible infected (SI) of DPO-14 (susceptible) genotype. Expression of 11 genes involved in plant defense quantified accordingly using RT-qPCR.ConclusionsThis study for the first time provides the glimpse of transcriptional responses to the DM resistance in Isabgol. The genes and pathways will be helpful in further investigating the molecular mechanisms associated with DM disease resistance in Isabgol and to develop control mechanisms accordingly.
Directional preference of otolith-related neurons in vestibular nucleus
Authors: Nguyen Nguyen , Kim Kyu-Sung , Kim Gyutae 
Published: March 2020

Abstract
Background: Due to the paired structure of two labyrinths at both sides of ear, their communication is conducted through the interconnected commissural pathway. The close interconnection produces the neural responding property in vestibular nucleus, and the mechanical movement of the hair cells mainly specifies the property. However, the mechanism to initiate the responding property was evident based on the structure, but few direct experimental data were provided to understand the responding property based on the structure.Experimental Approach: The directional preference was investigated, which was one of critical neural responding property to illustrate the functional structure. Also, a chemically induced unilateral labyrinthectomy (UL) was performed to emphasize the preference. For the model evaluation, static and dynamic behavioral tests were applied, and the results demonstrated a practical model construction. Following the evaluation, an extracellular neural activity was conducted for the neuronal responses to the horizontal head rotation and the linear head movement.Results: Seventy seven neuronal activities were recorded from thirty SD rats (270-450 g, male), and total population was divided into three groups; left UL (20), sham (35), right UL (22). Based on the directional preference, two sub-groups were again classified as contra- and ipsi-preferred neurons. There was no significance between those sub-groups (contra-: 15/35, 43%; ipsi-: 20/35, 57%) in sham model. However, more ipsi-preferred neurons (19/22, 86%) were observed after right UL while left UL caused more contra-preferred neurons (13/20, 65%). In particular, the convergent neurons mainly led this biased difference in the population (ipsi-: 100% after right UL & contra-: 89% after left UL).Conclusion: The directional preference was evenly maintained under a normal vestibular function, and its unilateral loss biased the directional preference of the neurons, depending on the side of lesion. Moreover, the dominance of the directional preference was mainly led by the convergent neurons which had the neural information related with head rotation and linear translation.
Estimating the daily trend in the size of the COVID-19 infected population in Wuhan
Authors: Lin Qiushi , You Chong , Zhou Xiao-Hua 
Published: March 2020

Abstract
There has been an outbreak of coronavirus disease (COVID-19) in Wuhan city, Hubei province, China since December 2019. Cases have been exported to other parts of China and many other countries. We provide estimates of the daily trend in the size of the epidemic in Wuhan based on detailed information of 10,940 confirmed cases outside Hubei province.
In this modelling study, we first estimate the epidemic size in Wuhan from January 11, 2020, to February 13, 2020, based on the confirmed cases outside Hubei province that left Wuhan by January 23, 2020. Since some confirmed cases have no information on whether they visited Wuhan before, we adjust for these missing values. We then calculate the reporting rate in Wuhan from January 20, 2020, to February 13, 2020. Finally, we estimate the date when the first patient was infected.
We estimate the number of cases that should be reported in Wuhan by January 11, 2020, is 4,094 (95% confidence interval [CI]: 3,980 – 4,211) and 58,153 (95% CI: 56,532 – 59,811) by February 13, 2020. The reporting rate has grown rapidly from 1.41% (95% CI: 1.37% - 1.45%) on January 20, 2020, to 32.15% (95% CI: 31.26% - 33.07%) on February 11, 2020, and reaches 61.89% (95% CI: 60.17% - 63.66%) on February 13, 2020. The date of first infection is estimated as November 30, 2019.
The estimated reporting rate has increased rapidly to over 60% on February 13, 2020, mainly because the inclusion of 14,031 clinically diagnosed cases in the case reports of Wuhan. This might indicate that clinical diagnosis could be a good complement to the current method of confirmation. The currently reported number of 35,991 cases as of February 13, 2020, is still far below our estimate of 58,153. There may still be a lot of unreported cases. More thorough screening of all patients with a mild or moderate symptoms of respiratory diseases should be conducted to better control the spread of COVID-19.
Removal of co-existing fluoride, calcium, magnesium, and carbonates, by non-chemical induced electrolysis system for drinking and industrial purposes
Authors: Amarasooriya A. A. G. D. , Kawakami Tomonori 
Published: March 2020

Abstract
An electrolysis (ELC) system was proposed to remove co-existing F−, Ca2+, Mg2+, CO32−, and HCO3− from groundwater without the addition of any chemicals. The proposed system utilized an ELC cell composed of non-corrosive platinum and stainless steel electrodes. Ion removal mechanisms, performance against different ion concentrations, and charge loading were studied and compared with drinking and industrial water quality guidelines. System performance with real groundwater was also examined. Results revealed that ELC effectively removes (CO32− + HCO3−) in the anode as CO2, and (CO32− + HCO3−), Ca2+, and Mg2+ in cathode as MgCO3, CaCO3, and Mg(OH)2. F− was removed by co-precipitation with Mg(OH)2 and Coulomb transfer. Maximum removal of 58%-F−, 42%-Ca2+, and 95%-Mg2+ were observed at a charge loading of 1500 C/L. With increasing Ca2+ and Mg2+, removal increments of cathode F−, Ca2+, Mg2+, and (CO32− + HCO3−) were noticed. To meet drinking water guidelines value of 1.5 mg/L of F−, minimum initial ion concentration ranges should be within F− &lt; 4.29–6 mg/L, Mg2+ &lt; 75–125 mg/L, Ca2+ &gt; 50 mg/L, and (CO32− + HCO3−) &lt; 10–0 mmol/L for 1500 C/L. The anode delivered the quality water which meets industrial boiler water alkalinity guideline for the initial (CO32− + HCO3−) &lt; 12.5 meq/L. The community-scale treatment system established in Sri Lanka confirmed smooth operation with a higher removal of F− and Ca2+ in the cathode and (CO32− + HCO3−) in the anode which can be slightly approximated with laboratory results.
Tactile Angle Discrimination Decreases due to Subjective Cognitive Decline in Alzheimer’s Disease
Authors: Zhang Zhilin , Chen Guanqun , Zhang Jian , Yan Tianyi , Go Ritsu , Fukuyama Hidenao , Wu Jinglong , Han Ying , Li Chunlin 
Published: March 2020

Background:
Subjective Cognitive Decline (SCD) is the early preclinical stage of Alzheimer's
Disease (AD). Previous study provided an invaluable contribution by showing that a tactile
angle discrimination system can be used to distinguish between healthy older individuals and patients
with mild cognitive impairment and AD. However, that study paid little attention to the relationship
between tactile angle discrimination and SCD. Therefore, a means of differentiating Normal Controls
(NCs), elderly subjects with SCD, patients with amnestic Mild Cognitive Impairment (aMCI), and AD
is urgently needed.

Methods:
In the present study, we developed a novel tactile discrimination device that uses angle stimulation
applied to the index finger pad to identify very small differences in angle discrimination between
the NC (n = 30), SCD (n = 30), aMCI (n = 30), and AD (n = 30) groups. Using a three-alternative
forced-choice and staircase method, we analyzed the average accuracy and threshold of angle
discrimination.

Results:
We found that accuracy significantly decreased while thresholds of angle discrimination increased
in the groups in the following order: NC, SCD, aMCI, and AD. The area under the receiver operating
characteristic curve also indicated that the tactile angle discrimination threshold was better than
Mini-Mental State Examination scores in distinguishing NC individuals and SCD patients.

Conclusion:
These findings emphasize the importance of tactile working memory dysfunction in explaining
the cognitive decline in angle discrimination that occurs in SCD to AD patients and offer further
insight into the very early detection of subjects with AD.
Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link
Authors: Brzecka Anna , Madetko Natalia , Nikolenko Vladimir N. , Ashraf Ghulam M. , Ejma Maria , Leszek Jerzy , Daroszewski Cyryl , Sarul Karolina , Mikhaleva Liudmila M. , Somasundaram Siva G. , Kirkland Cecil E. , Bachurin Sergey O. , Aliev Gjumrakch 
Published: March 2020

:
There is an increasing number of patients worldwide with sleep disturbances and diabetes.
Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous
causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral
neuropathy and nocturia, or associated other sleep disorders, such as sleep breathing disorders
or sleep movement disorders, may influence sleep quality and quantity. Both sleep disorders and
diabetes may lead to cognitive impairment. The risk of development of cognitive impairment in
diabetic patients may be related to vascular and non-vascular and other factors, such as hypoglycemia,
hyperglycemia, central insulin resistance, amyloid and tau deposits and other causes. Numerous
sleep disorders, e.g., sleep apnea, restless legs syndrome, insomnia, and poor sleep quality are
most likely are also associated with cognitive impairment. Adequate functioning of the system of
clearance of the brain from toxic substances, such as amyloid β, i.e. glymphatic system, is related to
undisturbed sleep and prevents cognitive impairment. In the case of coexistence, sleep disturbances
and diabetes either independently lead to and/or mutually aggravate cognitive impairment.
Long-acting Injectable vs. Oral Antipsychotics: Adherence, Persistence and Switching over three Years of Real-life Analysis
Authors: Romagnoli Alessia , Santoleri Fiorenzo , Costantini Alberto 
Published: March 2020

Background:
Persistence and adherence to treatment are considered efficacy outcomes
in psychiatric disorders. One of the best ways to improve these values in patients with psychiatric
disorders is to prefer Long-Acting Injectable (LAI) drugs to oral AP.

Objective:
The objective of this study is to evaluate adherence, persistence and switching of antipsychotics
and compare in real life long-acting with oral formulations.

Materials and methods:
This pharmacological, observational, retrospective and non-interventional
study involved all patients of the ASL of Pescara treated in the front-line with AP in the period
between January 2011 and February 2019. Adherence was measured using the ratio between the
received daily dose and prescribed daily dose. Persistence to treatment with antipsychotics was
calculated as the daily difference between the beginning and end of treatment.

Results:
We examined 840 patients treated with aripiprazole, 130 patients treated with paliperidone
and 925 patients treated with risperidone. Adherence was significantly better in long-acting formulations
with values of 0.89 (aripiprazole) and 0.82 (paliperidone and risperidone) than in oral formulations
with values of 0.78, 0.70 and 0.58, respectively (p> 0.999, p= 0.0091, p=<	0.0001). Threeyear
persistence curves relating to three study drugs did not show a statistically significant difference
(p = 0.3314). Persistence curves based on formulation have not shown a statistically significant
difference (p= 0, 4658, p=0, 4794, p=0, 2199 for ariprazolo, paliperidone and risperidone, respectively).
7% of patients were treated with aripiprazole, 12% of patients were treated with risperidone
and 28% of patients were treated with paliperidone switched therapy.

Conclusions:
In all the drugs of present study, adherence values were better in LAI than in OA,
whereas no statistically significant difference was found in persistence values.
Assessing Breast Cancer Survivors’ Perceptions of Using Voice-Activated Technology to Address Insomnia: Feasibility Study Featuring Focus Groups and In-Depth Interviews
Authors: Arem Hannah , Scott Remle , Greenberg Daniel , Kaltman Rebecca , Lieberman Daniel , Lewin Daniel 
Published: March 2020

Background
Breast cancer survivors (BCSs) are a growing population with a higher prevalence of insomnia than women of the same age without a history of cancer. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to be effective in this population, but it is not widely available to those who need it.

Objective
This study aimed to better understand BCSs’ experiences with insomnia and to explore the feasibility and acceptability of delivering CBT-I using a virtual assistant (Amazon Alexa).

Methods
We first conducted a formative phase with 2 focus groups and 3 in-depth interviews to understand BCSs’ perceptions of insomnia as well as their interest in and comfort with using a virtual assistant to learn about CBT-I. We then developed a prototype incorporating participant preferences and CBT-I components and demonstrated it in group and individual settings to BCSs to evaluate acceptability, interest, perceived feasibility, educational potential, and usability of the prototype. We also collected open-ended feedback on the content and used frequencies to describe the quantitative data.

Results
We recruited 11 BCSs with insomnia in the formative phase and 14 BCSs in the prototype demonstration. In formative work, anxiety, fear, and hot flashes were identified as causes of insomnia. After prototype demonstration, nearly 79% (11/14) of participants reported an interest in and perceived feasibility of using the virtual assistant to record sleep patterns. Approximately two-thirds of the participants thought lifestyle modification (9/14, 64%) and sleep restriction (9/14, 64%) would be feasible and were interested in this feature of the program (10/14, 71% and 9/14, 64%, respectively). Relaxation exercises were rated as interesting and feasible using the virtual assistant by 71% (10/14) of the participants. Usability was rated as better than average, and all women reported that they would recommend the program to friends and family.

Conclusions
This virtual assistant prototype delivering CBT-I components by using a smart speaker was rated as feasible and acceptable, suggesting that this prototype should be fully developed and tested for efficacy in the BCS population. If efficacy is shown in this population, the prototype should also be adapted for other high-risk populations.
Análisis de la marcha y el equilibrio mediante el uso de sensores inerciales: estudio prospectivo, longitudinal, no aleatorio
Authors: Betances Reinoso Frank Alberto , Lopez Montes Tania , Rodríguez Ontiveros Víctor M. , Chiesa Estomba Carlos 
Published: March 2020

Antecedentes: la población mundial envejece de manera acelerada. Una tercera parte de los mayores de 65 años se cae por lo menos una vez al año, y esta prevalencia se incrementan a la mitad cuando se superan los 69 años.
Objetivo: establecer la sensibilidad del uso de sensores inerciales para determinar la marcha y las rotaciones del tronco en un grupo de individuos sanos.
Materiales: utilizamos tres sensores inerciales de nueve ejes, junto a un mismo número de microcontroladores, los cuales enviaron la información vía bluetooth al orde-nador, el procesamiento de los datos fue realizado mediante un programa de análisis desarrollado en MATLAB. Para analizar la sensibilidad de los sensores utilizamos el proto-colo de Akram et al.,5 modificado, el cual consta de cinco actividades.
Resultados: en nuestro estudio participaron seis volun-tarios, con una media de edad de 29 años, con un rango de edad de 25 a 33 años. Los sensores fueron capaces de detectar múltiples variables, entre ellas la elevación máxima y mínima de las piernas, número de pasos, el grado de inclinación del tronco, giro, velocidad y cadencia.
Conclusión: los resultados hasta ahora obtenidos son prometedores y consideramos que el uso de múltiples sensores inerciales para valorar la marcha y el equilibrio podrían resultar en una nueva herramienta para el diag-nóstico y seguimiento de personas con trastorno de la marcha y equilibrio.
Marcadores tumorales y su valor en ginecología
Authors: María Olivares Anyela , Carolina Pereyra Diana , Richardson Daniel , Reyes Omaira 
Published: March 2020

Los marcadores tumorales (MT) son moléculas que pueden estar elevadas en presencia de un cáncer, bien como reacción del huésped ante el tumor o bien como producto del propio tumor. Los MT no son específicos de las neoplasias, y pueden encontrarse concentraciones apreciables en un gran número de situaciones fisiológicas o patológicas tumorales. Son útiles para la detección precoz de un cáncer, para establecer el estadiaje, la respuesta a la terapia, predecir las recurrencias, presentar una elevada sensibilidad, especificidad y valor predictivo positivo y ser órgano-específicos y tumor-específicos. Dentro de los que representan más relevancia y valor en ginecología se destacan: el CEA, AFP, betaHCG, CA125, CA 15.3, CA 19.9, SCC, Citoqueratinas y LDH. Los marcadores biológicos son cambios medibles, ya sean bioquímicos, fisiológicos o morfológicos que se asocian a la exposición a algún tóxico. En las patologías oncológicas-gineco-lógicas son referidos con frecuencia los BRCA1, BCRA2 y el Her2; también pueden mencionarse: los receptores hormonales (ER y PR).
El verdadero valor clínico en ginecología reside en el segui-miento de las pacientes, tanto para detectar una recidiva temprana como para evaluar la efectividad del tratamiento. En general, los marcadores tumorales y los marcadores biológicos pueden ser la clave para reducir la mortalidad por cáncer a nivel mundial. Por lo que, nos proponemos esta revisión bibliográfica para realzar los MT más utili-zados en la práctica clínica en el área de ginecología.
Comportamiento de la mortalidad en el hospital infantil Dr. Robert Reid Cabral, Santo Domingo, República Dominicana, periodo 2013- 2017
Authors: Elías Melgen Ricardo , Contreras Cristina , Díaz Rodríguez Cristian 
Published: March 2020

Introducción: el análisis de la mortalidad hospitalaria permite evaluar la calidad de la asistencia médica. Las últimas publicaciones sobre mortalidad en el Hospital Infantil Dr. Robert Reid Cabral datan de 1997.
Objetivo: conocer el comportamiento de la mortalidad en el Hospital Infantil Dr. Robert Reid Cabral durante el periodo 2013–2017
Métodos: estudio descriptivo. Se revisaron los libros de registro y actas de defunciones de los pacientes fallecidos en el Hospital Dr. Robert Reid Cabral durante el periodo 2013–2017.
Resultados: 3,800 pacientes fallecieron, en promedio 760 fallecidos por año (margen 679-868).79.9 % con menos de 5 años de edad; las muertes en menores de 1 año de edad representaron el 61.3 % y en el periodo neonatal el 26.1 %. La Sepsis/Shock Séptico (43.4 %) y la Hemorragia Pulmonar (15.4 %) fueron los dos principales diagnós-ticos de defunción; el 34 % de los fallecidos presentaban una morbilidad asociada al diagnóstico de defunción y en el 40 % la morbilidad asociada era una malformación congénita. El 69.5 % fallecieron en la Unidad de Cuidados Intensivos Pediátricos o Neonatal y 40 % de los pacientes fallecieron antes de las 48 horas de su ingreso al hospital.
Conclusión: el grupo etario de mayor mortalidad son los menores de 1 año de edad, se evidencia un alto porcentaje de muertes con enfermedad crónica y malformaciones congénitas asociadas. El hecho de que el 40 % de los pacientes fallecieran antes de las 48 horas de su ingreso, indica la condición de gravedad en que estos pacientes llegan al hospital.