bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotropic Drug Use in Children with Autism Spectrum Disorder Admitted to a Training and Research Hospital Outpatient Clinic: A Retrospective Cross-Sectional Study
Authors: Uygun Sabide Duygu , Çakmak Fatma Hülya , Canlı Merve , Temeltürk Rahime Duygu , Efe Ayşegül , Gürel Yusuf , Açıkel Sadettin Burak , Çetinkaya Miray 
Published: December 2020

AbstractThis study aimed to examine demographic and clinical variables, psychiatric comorbidities, the prevalence of psychotropic drug use, relationships between drug use, demographic and clinical variables, and predictors of drug use in children with autism spectrum disorder (ASD) admitted to a training and research hospital outpatient clinic. Four hundred and eleven children with ASD admitted to the Department of Child and Adolescent Psychiatry, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, between October 1, 2019 and December 31, 2019, were retrospectively reviewed. Demographic and clinical variables, psychiatric comorbidities, and characteristics of drug use for the cases were recorded. Psychotropic drug use was found in 34.3% (n = 141) of the cases. Our results revealed male sex and psychiatric comorbidity as predictors of psychotropic drug use. Antipsychotics were the most prescribed drugs, and the most common psychiatric comorbidity was conduct disorder. Also, children with ASD who had been toilet-trained, and could express sentences but were illiterate, were using psychotropic drugs more often than others. Future multicentered, large clinic-based studies from training and research hospitals should focus on trends of treatment in psychiatric comorbidities accompanying ASD, and constitute a systematic approach for the psychopharmacological treatment of these cases.
Effects of magnetic frequency and the coupled magnetic-mechanical loading on a ferromagnetic shape memory alloy
Authors: Wu Hong-Hui , Ke Yubin , Zhu Jiaming , Wu Zhenduo , Wang Xun-Li 
Published: December 2020

Abstract
In the present work, the microstructure evolution and macro-response of a ferromagnetic shape memory alloy under stimuli of magnetic fields with different frequency and coupled magnetic-mechanical loading are investigated via a real-space phase field simulation. It is found that the coercive field is reduced from 0.724 to 0.423 with the magnetic frequency f decrease from

2.5
×

10

−
5

Hz to

0.833
×

10

−
5

Hz, wherein the concomitant domain wall motion and magnetization rotation are captured as well. Moreover, simulation results demonstrate that, under the coupled magnetic-mechanical loading, the coercive field of the magnetic hysteresis loop could be reduced by applying a compressive strain perpendicular to the magnetic field direction. The domain evolution is mainly divided into three types during the coupled magnetic-mechanical loading, namely (a) domain wall motion with the magnetization rotation, (b) pure magnetization rotation, and (c) 180° domain coordinated domain switching. To better understand the domain evolution, we propose an index

S
=

m
1

avg

+

m
2

avg

, with

m
1

avg

and

m
2

avg

indicating the absolute value of the averaged magnetization component

m
1

and

m
2

over the whole studied system, to characterize the magnetization change during the microstructure evolution.
Ag-nanoparticles-loaded Ba0.85Ca0.15Ti0.9Zr0.1O3 for multicatalytic dye degradation
Authors: Sharma Moolchand , Singh Gurpreet , Vaish Rahul 
Published: December 2020

Abstract
Ba0.85Ca0.15Ti0.9Zr0.1O3 (BCZTO) ferroelectric ceramic loaded with Ag nanoparticles (NPs) was explored for its photo/piezocatalytic performance. The presence of Ag loading on BCZTO ceramic was confirmed using electron microscopes. X-ray photoelectron spectroscopy revealed the metallic chemical state of Ag NPs loaded on the surface of BCZTO ceramic. The absorbance spectrum of the Ag-loaded BCZTO sample showed a visible light absorption hump due to the phenomenon of surface plasmonic resonance. During the photocatalysis process, the

˜

99% of rhodamine B (RB) dye was degraded in aqueous solution using the Ag-loaded BCZTO sample, showing its promising photocatalysis activity. During the piezocatalysis process, the

˜

95% of RB dye was degraded using the Ag-loaded BCZTO sample, showing its promising piezocatalytic activity. The ·OH radical species were found responsible for the photocatalytic and piezocatalytic performance. The photo/piezocatalytic performance was found to be consistent over five cycles, indicating promising reusability of the Ag-loaded BCZTO sample.
A layered single-side readout depth of interaction time-of-flight-PET detector
Authors: Bläckberg L , Sajedi S , El Fakhri G , Sabet H 
Published: December 2020

Abstract
We are exploring a scintillator-based PET detector with potential of high sensitivity, depth of interaction (DOI) capability, and timing resolution, with single-side readout. Our design combines two previous concepts: (1) multiple scintillator arrays stacked with relative offset, yielding inherent DOI information, but good timing performance has not been demonstrated with conventional light sharing readout. (2) Single crystal array with one-to-one coupling to the photodetector, showing superior timing performance compared to its light sharing counterparts, but lacks DOI. The combination, where the first layer of a staggered design is coupled one-to-one to a photodetector array, may provide both DOI and timing resolution and this concept is here evaluated through light transport simulations. Results show that: (1) unpolished crystal pixels in the staggered configuration yield better performance across all metrics compared to polished pixels, regardless of readout scheme. (2) One-to-one readout of the first layer allows for accurate DOI extraction using a single threshold. The number of multi pixel photon counter (MPPC) pixels with signal amplitudes exceeding the threshold corresponds to the interaction layer. This approach was not possible with conventional light sharing readout. (3) With a threshold of 2 optical photons, the layered approach with one-to-one coupled first layer improves timing close to the MPPC compared to the conventional one-to-one coupling non-DOI detector, due to effectively reduced crystal thickness. Single detector timing resolution values of 91, 127, 151 and 164 ps were observed per layer in the 4-layer design, to be compared to 148 ps for the single array with one-to-one coupling. (4) For the layered design with light sharing readout, timing improves with increased MPPC pixel size due to higher signal per channel. In conclusion, the combination of straightforward DOI determination, good timing performance, and relatively simple design makes the proposed concept promising for DOI-Time-of-Flight PET detectors.
Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system
Authors: Zeraatkar Navid , Auer Benjamin , Kalluri Kesava S , May Micaehla , Momsen Neil C , Richards R Garrett , Furenlid Lars R , Kuo Phillip H , King Michael A 
Published: December 2020

Abstract
We are developing a multi-detector pinhole-based stationary brain-dedicated SPECT system: AdaptiSPECT-C. In this work, we introduced a new design prototype with multiple adaptable pinhole apertures for each detector to modulate the multiplexing by employing temporal shuttering of apertures. Temporal shuttering of apertures over the scan time provides the AdaptiSPECT-C with the capability of multiple-frame acquisition. We investigated, through analytic simulation, the impact of projection multiplexing on image quality using several digital phantoms and a customized anthropomorphic phantom emulating brain perfusion clinical distribution. The 105 pinholes in the collimator of the system were categorized into central, axial, and lateral apertures. We generated, through simulation, collimators of different multiplexing levels. Several data acquisition schemes were also created by changing the imaging time share of the acquisition frames. Sensitivity increased by 35% compared to the single-pinhole-per-detector base configuration of the AdaptiSPECT-C when using the central, axial, and lateral apertures with equal acquisition time shares within a triple-frame scheme with a high multiplexing scenario. Axial and angular sampling of the base configuration was enhanced by adding the axial and lateral apertures. We showed that the temporal shuttering of apertures can be exploited, trading the sensitivity, to modulate the multiplexing and to acquire a set of non-multiplexed non-truncated projections. Our results suggested that reconstruction benefited from utilizing both non-multiplexed projections and projections with modulated multiplexing resulting in a noticeably reduction in the multiplexing-induced image artefacts. Contrast recovery factor improved by 20% (9%) compared to the base configuration for a Defrise (hot-rod) phantom study when the central and axial (lateral) apertures with equal time shares were combined. The results revealed that, as an overall trend at each simulated multiplexing level, lowest normalized root-mean-square errors for the brain gray-matter regions were achieved with the combined usage of the central apertures and axial/lateral apertures.
Evolution of vortex matter, phase diagram, and upper critical field in the FeSe1−x
S
x
system
Authors: Vlasenko V A , Sadakov A V , Romanova T A , Yu Gavrilkin S , Dik A V , Sobolevskiy O A , Massalimov B I , Chareev D A , Vasiliev A N , Maltsev E I , Kuzmicheva T E 
Published: December 2020

Abstract
We present a comprehensive study of vortex matter in the FeSe1−x
S
x
system with various doping degree. The influence of sulphur substitution on peak effect occurrence is studied. Additionally, we study a possible vortex liquid–vortex glass/lattice transition and find an evidence that the vortex liquid–vortex glass phase transition in FeSe1−x
S
x
has a quasi two–dimensional nature. We investigate the upper critical field behaviour in FeSe1−x
S
x
system, and found that the upper critical field is higher than that predicted by the Werthamer–Helfand–Hohenberg (WHH) model, whereas its temperature dependence could be fitted within a two-band framework. Finally, a detailed H–T phase diagram is presented.
La1−

x
Mn1−

y
O3±

δ
buffer layers on inclined substrate deposited MgO templates for coated conductors
Authors: Troshyn Oleksiy , Hoffmann Christian , Große Veit , Hänisch Jens , Becker Lucas , Gross Rudolf 
Published: December 2020

Abstract
Most commercial high-temperature superconducting coated conductors based on ion beam assisted MgO deposited templates use LaMnO3 (LMO) films as the terminating buffer layer. In contrast, coated conductors based on inclined substrate deposition (ISD)-MgO technology are still produced with homoepitaxial (homoepi)-MgO as the cap layer. In this work we report on the deposition of LMO buffer layers on ISD-MgO/homoepi-MgO by electron beam physical vapor deposition. The growth parameters of textured LMO films were studied systematically and their properties were optimized regarding the critical current density (J
c) of the subsequently deposited DyBa2Cu3O7−δ
(DyBCO) superconducting films. LMO films without outgrowths at the surface were obtained at growth rates of up to 4 Å s−1. Despite the formation of non-stoichiometric LMO films containing 59% La, single-phase films were obtained at substrate temperatures below 775 °C and at oxygen partial pressures of up to 4 × 10−4 mbar due to a large homogeneity region towards La. The J
c values of DyBCO films deposited on LMO were found to be independent of the LMO thickness in a range from 50 nm to 450 nm. DyBCO films on LMO reach J
c = 0.83 MA cm−2 at 77 K in zero applied field. This value is up to 30% higher than those of DyBCO films grown directly on homoepi-MgO. The wide range of LMO growth parameters and higher J
c values of DyBCO on LMO compared to DyBCO on homoepi-MgO make this material attractive for its use in manufacturing coated conductors based on ISD-MgO technology.
Endorectal digital prostate tomosynthesis (endoDPT): a proof-of-concept study
Authors: Steiner Joseph , Matthews Kenneth , Jia Guang 
Published: December 2020

Abstract
In this study we present endorectal digital prostate tomosynthesis (endoDPT), a proposed method of high resolution prostate imaging using an endorectal x-ray sensor and an external x-ray source. endoDPT may be useful for visualizing the fine detail of small structures such as low dose rate brachytherapy (LDRBT) seeds that are difficult to visualize with current methods. The resolution of endoDPT was characterized through measurement of the modulation transfer function (MTF) and artifact spread function (ASF) in computational and physical phantoms. The qualitative resolution of endoDPT was assessed relative to computed tomography (CT) through imaging of LDRBT seeds implanted in ex vivo canine prostates. The x-ray sensor MTF reached 10% at 11.50 mm−1, the reconstruction algorithm MTF reached a maximum at 7.08 mm−1, and the ASF was 2.5 mm (full-width at half-maximum). Fine structures in LDRBT seeds like the 0.05 mm thick shell were visible with endoDPT but not CT. All endoDPT images exhibited an overshoot artifact. The measured MTFs were consistent with other studies using similar x-ray sensors and demonstrated improved resolution compared to digital breast tomosynthesis; this result was due to the smaller endoDPT x-ray sensor detection element size and quantitatively demonstrates the high resolution of endoDPT. The ASF demonstrated worse depth resolution compared to in-plane resolution, due to partial angular sampling; partial angular sampling also caused the observed overshoot artifact in the endoDPT images. However, endoDPT still was able to visualize fine structures such as the LDRBT seed shell to a much higher degree than CT. This high-resolution visualization may be useful for improvements in patient specific LDRBT dosimetry. Overall, these results indicate endoDPT is capable of high in-plane spatial resolution and is thus well poised for optimization and studies assessing clinical utility.
Overview of cold chain development in China and methods of studying its environmental impacts
Authors: Dong Yabin , Xu Ming , Miller Shelie A 
Published: December 2020

Abstract
The cold chain (refrigerated supply chain) is an important application of refrigeration technologies. The capacity of the cold chain industry is growing rapidly in emerging economies such as China, leading to significant environmental impacts, especially greenhouse gas (GHG) emissions. By conducting the literature review, this study begins with presenting a comprehensive overview of the cold chain industry in China. We observed that China has a large total cold warehouse capacity but low capacity per capita. Then, we directly link the example of the cold chain in China to the methods of evaluating the GHG emissions from the cold chain industry. It is observed that existing studies either primarily focus on the lifecycle of food with less consideration on the cold chain facilities or primarily focus on the lifetime of a certain stage of the cold chain (e.g., refrigerated transportation) with less consideration on food. Neither frameworks capture the entire cold chain system. Moreover, we argue that existing studies lack investigations of the cold chain GHG emissions on the national scale. To evaluate the overall GHG emissions, we recommended that one can use the bottom-up approach. First, use the lifecycle assessment (LCA) to estimate the single-unit level (e.g., one kg food, one particular refrigerated warehouse) cold chain emissions. Second, aggregate up to the national scale by the distribution patterns of the cold chain networks. Finally, we identify the crucial future issues regarding collecting cold chain lifecycle inventory data, investigating the cold chain network and the overall environmental impacts in China, regulation and technology needs for expanding the clean refrigeration technologies, and the implications of the cold chain development to water, land, and society.
Epigenome-wide association study (EWAS) for potential transgenerational disease epigenetic biomarkers in sperm following ancestral exposure to the pesticide methoxychlor
Authors: Nilsson Eric E , Thorson Jennifer L M , Ben Maamar Millissia , Beck Daniel , Skinner Michael K 
Published: December 2020

Abstract
Environmental exposures such as chemical toxicants can alter gene expression and disease susceptibility through epigenetic processes. Epigenetic changes can be passed to future generations through germ cells through epigenetic transgenerational inheritance of increased disease susceptibility. The current study used an epigenome-wide association study (EWAS) to investigate whether specific transgenerational epigenetic signatures of differential DNA methylation regions (DMRs) exist that are associated with particular disease states in the F3 generation great-grand offspring of F0 generation rats exposed during gestation to the agricultural pesticide methoxychlor. The transgenerational epigenetic profiles of sperm from F3 generation methoxychlor lineage rats that have only one disease state were compared to those that have no disease. Observations identify disease specific patterns of DMRs for these transgenerational rats that can potentially serve as epigenetic biomarkers for prostate disease, kidney disease, obesity, and the presence of multiple diseases. The chromosomal locations, genomic features, and gene associations of the DMRs are characterized. Disease specific DMR sets contained DMR-associated genes that have previously been shown to be associated with that specific disease. Future epigenetic biomarkers could potentially be developed and validated for humans as a disease susceptibility diagnostic tool to facilitate preventative medicine and management of disease.
Intra-night optical variability of γ −ray detected narrow-line Seyfert1 galaxies
Authors: Ojha Vineet , Chand Hum , Krishna Gopal 
Published: December 2020

Abstract
We report the first attempt to systematically characterise intra-night optical variability (INOV) of the rare and enigmatic subset of Narrow-Line Seyfert1 galaxies (NLSy1s), which is marked by detection in the γ-ray band and is therefore endowed with Doppler boosted relativistic jets, like blazars. However, the central engines in these two types of AGN are thought to operate in different regimes of accretion rate. Our INOV search in a fairly large and unbiased sample of 15 γ-ray NLSy1s was conducted in 36 monitoring sessions, each lasting ≥ 3 hrs. In our analysis, special care has been taken to address the possible effect on the differential light curves, of any variation in the seeing disc during the session, since that might lead to spurious claims of INOV from such AGN due to the possibility of a significant contribution from the host galaxy to the total optical emission. From our observations, a duty cycle (DC) of INOV detection in the γ-ray NLSy1s is estimated to be around 25% - 30%, which is comparable to that known for blazars. This estimate of DC will probably need an upward revision, once it becomes possible to correct for the dilution of the AGN’s nonthermal optical emission by the (much steadier) optical emission contributed not only by the host galaxy but also the nuclear accretion disc in these high Eddington rate accretors. Finally, we also draw attention to the possibility that sharp optical flux changes on sub-hour time scale are less rare for γ-ray NLSy1s, in comparison to blazars.
New insights into time-series analysis IV: panchromatic and flux-independent period finding methods
Authors: Ferreira Lopes C E , Cross N J G , Jablonski F 
Published: December 2020

ABSTRACT
New time-series analysis tools are needed in disciplines as diverse as astronomy, economics, and meteorology. In particular, the increasing rate of data collection at multiple wavelengths requires new approaches able to handle these data. The panchromatic correlated indices $K^{(s)}_{(fi)}$ and $L^{(s)}_{(pfc)}$ are adapted to quantify the smoothness of a phased light-curve resulting in new period-finding methods applicable to single- and multiband data. Simulations and observational data are used to test our approach. The results were used to establish an analytical equation for the amplitude of the noise in the periodogram for different false alarm probability values, to determine the dependency on the signal-to-noise ratio, and to calculate the yield rate for the different methods. The proposed method has similar efficiency to that found for the string length period method. The effectiveness of the panchromatic and flux-independent period finding methods in single as well as multiple wavebands that share a fundamental frequency is also demonstrated in real and simulated data.
O vi traces photoionized streams with collisionally ionized boundaries in cosmological simulations of z ∼ 1 massive galaxies
Authors: Strawn Clayton , Roca-Fàbrega Santi , Mandelker Nir , Primack Joel , Stern Jonathan , Ceverino Daniel , Dekel Avishai , Wang Bryan , Dange Rishi 
Published: December 2020

ABSTRACT
We analyse the distribution and origin of O vi in the Circumgalactic Medium (CGM) of dark-matter haloes of ∼1012 M⊙ at z ∼ 1 in the VELA cosmological zoom-in simulations. We find that the O vi in the inflowing cold streams is primarily photoionized, while in the bulk volume it is primarily collisionally ionized. The photoionized component dominates the observed column density at large impact parameters (≳0.3Rvir), while the collisionally ionized component dominates closer in. We find that most of the collisional O vi, by mass, resides in the relatively thin boundaries of the photoionized streams. Thus, we predict that a reason previous work has found the ionization mechanism of O vi so difficult to determine is because the distinction between the two methods coincides with the distinction between two significant phases of the CGM. We discuss how the results are in agreement with analytic predictions of stream and boundary properties, and their compatibility with observations. This allows us to predict the profiles of O vi and other ions in future CGM observations and provides a toy model for interpreting them.
Profiling of ribose methylations in ribosomal RNA from diffuse large B-cell lymphoma patients for evaluation of ribosomes as drug targets
Authors: Krogh Nicolai , Asmar Fazila , Côme Christophe , Munch-Petersen Helga Fibiger , Grønbæk Kirsten , Nielsen Henrik 
Published: December 2020

AbstractCancer cells are addicted to ribosome biogenesis and high levels of translation. Thus, differential inhibition of cancer cells can be achieved by targeting aspects of ribosome biogenesis or ribosome function. Using RiboMeth-seq for profiling of the ∼112 2′-O-Me sites in human ribosomal RNA, we demonstrated pronounced hypomethylation at several sites in patient-derived diffuse large B-cell lymphoma (DLBCL) cell lines with a more severe perturbation in ABC-DLBCL compared to GBC-DLBCL. We extended our analysis to tumor samples from patients and demonstrated significant changes to the ribosomal modification pattern that appeared to consist of cell growth-related as well as tumor-specific changes. Sites of hypomethylation in patient samples are discussed as potential drug targets, using as an example a site in the small subunit (SSU-C1440) located in a ribosomal substructure that can be linked to DLBCL pathogenesis.