bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double-strand breaks can induce DNA replication and damage amplification in G2 phase-like oocytes of mice
Authors: Ma Jun-Yu , Feng Xie , Xie Feng-Yun , Li Sen , Chen Lei-Ning , Luo Shi-Ming , Ou Xiang-Hong 
Published: July 2020

AbstractBreak-induced DNA replication (BIR) have been detected not only in the genome of rare disease patients but also in cancer cells, however, the mechanisms of BIR formation haven’t been explained in details. In the late G2 phase-like mouse oocytes, we found DNA double-strand breaks (DSBs) could induce Rad51 dependent small-scale DNA replication. In addition, we also found the DSBs could be amplified in mouse oocytes, and the amplification could be inhibited by Rad51 inhibitor IBR2 and DNA replication inhibitor ddATP. Lastly, we found the DSB repair was relatively inefficiency in hybrid mouse oocytes compared with that of the purebred mouse oocytes. We found DSBs could induce BIR more easier in hybrid mouse oocytes, indicating the DNA repair in oocytes could be affected by the sequence differences between homologous chromatids. In summary, our results indicated that the condensed chromatin configuration in late G2 phase and the sequence similarity between broken DNA and template DNA are causing factors of BIR in mammalian genome, and the DNA damage could be amplified in late G2 phase cells.
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells
Authors: Tewari Ritika , Shayahati Bieerkehazhi , Fan Ying , Akimzhanov Askar M. 
Published: July 2020

AbstractZAP-70 is a cytoplasmic tyrosine kinase essential for T cell-mediated immune responses. Upon engagement of the T cell receptor, ZAP-70 is quickly recruited to the specialized plasma membrane domains, becomes activated and released to phosphorylate its laterally segregated downstream targets. A shift in ZAP-70 distribution at the plasma membrane is recognized as a critical step in T cell receptor signal transduction and amplification. However, the molecular mechanism supporting stimulation-dependent plasma membrane compartmentalization of ZAP-70 remains poorly understood. In this study, we identified previously uncharacterized reversible lipidation (S-acylation) of ZAP-70. We found that this post-translational modification of ZAP-70 is dispensable for its enzymatic activity. However, the lipidation-deficient mutant of ZAP-70 failed to propagate the T cell receptor signaling cascade suggesting that S-acylation is essential for ZAP-70 interaction with its protein substrates. The kinetics of ZAP-70 S-acylation were consistent with early T cell signaling events indicating that agonist-induced S-acylation is a part of the signaling mechanism controlling T cell activation and function.Significance StatementActivation of T cells is a critical part of the adaptive immune response to pathogen exposure. We found that ZAP-70, a regulatory protein essential for T cell activation, can undergo a post-translational modification with long chain fatty acids, known as S-acylation. In this report, we show that S-acylation of ZAP-70 is T cell receptor-dependent and required for its signaling function. We found that loss of ZAP-70 S-acylation resulted in T cell unresponsiveness to T cell receptor stimulation indicating that abnormalities in protein S-acylation can potentially contribute to the T cell immunodeficiency disorders.
Mutations primarily alter the inclusion of alternatively spliced exons
Authors: Baeza-Centurion Pablo , Miñana Belén , Valcárcel Juan , Lehner Ben 
Published: July 2020

AbstractGenetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common mechanism by which mutations cause disease. However, most exons expressed in any cell are highly-included in mature mRNAs. Here, by performing deep mutagenesis of highly-included exons and by analysing the association between genome sequence variation and exon inclusion across the transcriptome, we report that mutations only very rarely alter the inclusion of highly-included exons. This is true for both exonic and intronic mutations as well as for perturbations intrans. Therefore, mutations that affect splicing are not evenly distributed across primary transcripts but are focussed in and around alternatively spliced exons with intermediate inclusion levels. These results provide a resource for prioritising synonymous and other variants as disease-causing mutations.
Improving clinical practice through simulation training on intellectual disabilities: a longitudinal study
Authors: Iannelli Hannah , Tooley Camilla , Billon Grégoire , Cross Sean , Pathan James , Attoe Chris 
Published: July 2020

Purpose
Individuals health with intellectual disabilities (ID) experience comorbid physical and mental health needs and have poorer outcomes resulting in early mortality. Currently, many training provisions based on ID exist; however, limited research supports their effectiveness. High-fidelity simulation is an innovative training mechanism with promising preliminary results. This study aims to evaluate the longitudinal impact of simulation training on clinical practice in ID.

Design/methodology/approach
A mixed-method approach was used in this study. A one-day simulation course using actors who had ID was delivered to 39 health-care professionals from across London hospitals. Nine semi-structured interviews were conducted 12–18 months post training.

Findings
High-fidelity simulation training is an effective training modality, which has a sustainable impact on participants, their clinical practice and patients. Core features of the training including debriefing, the use and type of actors, scenario design and the facilitators are crucial learning mechanisms which impacts learning outcomes and changes to behaviour in clinical practice and settings.

Originality/value
To the best of the authors’ knowledge, this study is the first to longitudinally evaluate high-fidelity simulation training designed to improve the physical and mental health needs of those with ID. The research begins to bridge an important gap in the current literature, with a need for more research.
Tobacco smoking in three “left behind” subgroups: indigenous, the rainbow community and people with mental health conditions
Authors: Glover Marewa , Patwardhan Pooja , Selket Kyro 
Published: July 2020

PurposeThis paper aims to investigate the extent to which three subgroups – people with mental health conditions, people belonging to sexual minority and gender groups and Indigenous peoples – have been “left behind” by countries implementing the World Health Organization’s Framework Convention on Tobacco Control.Design/methodology/approachA general review of electronic bibliographical databases to provide an overview of smoking prevalence among the three groups and interventions designed specifically to reduce their smoking rates.FindingsAlthough explanations and specific rates differ, two trends are consistent across all three groups. First, information reported in the past two decades suggests that smoking prevalence is disproportionately high among people with mental health conditions, and in the rainbow and indigenous communities. Second, most cessation programmes are targeted at majority politically dominant groups, missing opportunities to reduce smoking rates in these minority communities.Research limitations/implicationsThere is a general dearth of data preventing detailed analysis. Better data collection efforts are required. Trials to identify effective smoking reduction interventions for marginalised groups are needed.Social implicationsIt is socially unjust that these groups are being systematically ignored by tobacco control initiatives. A failure to equitably reduce tobacco harms among all groups across society has contributed to the perceived concentration of smoking in some subgroups. The increasing stigmatisation of people who smoke then adds a marginality, compounding the negative effects associated with belonging to a marginalised group. Ongoing marginalisation of these groups is an important determinant of smoking.Originality/valueCross-case analysis of neglected subgroups with disproportionately high smoking rates suggests social marginalisation is a shared and important determinant of smoking prevalence.
Perceptions regarding academic social networks for scholarly communications
Authors: Al-Muomen Nujoud , Chaudhry Abdus Sattar , Al-Othinah Oroba 
Published: July 2020

Purpose
This study aims to investigate the perceptions of academics regarding the use and usefulness of academic social networks (ASNs) in the scholarly communication practices of faculty members in Kuwaiti Universities.

Design/methodology/approach
The study was conducted through a survey. In total, 100 faculty members from the disciplines of business administration, humanities and social sciences from three universities in Kuwait filled in an online questionnaire. The statistical feature of the Web-based tool was used for data analysis.

Findings
The results show that most faculty members are aware of the importance of ASNs. They perceive that these networks are useful, as more publications have become available, it has become easier for scholars to connect with colleagues who share similar research interests.

Research limitations/implications
The study is descriptive and restricted to a specific country (Kuwait). It also only covered faculty members from three academic disciplines. Furthermore, the use of a questionnaire, while appropriate for descriptive research, restricted us from conducting probing designed to gain deeper insights regarding participants’ motivations and explanations for not realizing the potential of these networks.

Practical implications
Future research should expand the scope of this study to cover faculty members from other disciplines (e.g. science, engineering and medicine), while also including more universities from other countries in the Arabian Gulf region. Future research should also examine how academics’ information-finding practices are changing as a result of the availability of information sources through ASNs.

Originality/value
No similar study has been conducted previously in Kuwait. This study provided useful information regarding the use and perceptions of ASNs in the context of faculty members of Kuwaiti universities. This information is of interest to scholars, information providers and those who design such networks.
MHD Marangoni boundary layer problem for hybrid nanofluids with thermal radiation
Authors: Aly Emad H. , Ebaid Abdelhalim 
Published: July 2020

PurposeThe purpose of this paper is to study flow of the Marangoni boundary layer pasta surface embedded in a porous medium saturated by a hybrid nanofluid in the presence of a magnetic field and thermal radiation.Design/methodology/approachThe governing model was converted into ordinary differential equations applying proper similarity transformations. Therefore, Laplace transform was used to exactly solve the resulted equations. Hence, the influence of the velocity profile and temperature distribution was investigated under impacts of the involved parameters.FindingsIn the case of regular fluid, i.e. the solid volume fractions are zeros, the current results are in a very good agreement with those in the literature. It was found that the velocity decreases (increases) on increasing the parameters of copper-nanoparticles volume fraction, magnetic field and suction (permeability and injection). Further, the temperature increases (decreases) with an increase of the copper-nanoparticles volume fraction, magnetic field, injection and radiation (permeability and suction).Originality/valueThe current results of the Marangoni boundary layer problem for hybrid nanofluids are new, original and extend the previous problems investigated by many authors for the case of regular/nano fluids.
Impact of outward FDI on home country exports
Authors: Bhasin Niti , Kapoor Kanika 
Published: July 2020

PurposeThe relationship of outward foreign direct investment (OFDI) with home country's exports has significant implications for policymakers as well as business managers of MNEs. Since BRICS nations have emerged as important sources as well as destinations of FDI, this paper aims to study the impact of OFDI from these countries on home country exports by using panel data for BRICS for time period 1993–2015.Design/methodology/approachThe author use panel unit root tests, panel cointegration, VECM and causality tests in the study.FindingsThe results reveal that OFDI has a negative and significant impact on home country exports indicating that outward FDI is a substitute for exports in these countries. It also indicates long-run causality from exports towards OFDI. There is no long-run causality running from OFDI to exports, suggesting that MNEs do not “connect” with home economies' firms through forward and backward linkages in value chain.Practical implicationsFrom the point of view of policymakers, it implies a net outflow of capital as the outflow of foreign investment would not be matched by any incremental export earnings since exports are getting substituted by production abroad. For business managers, it is indicative of a growing foreign market that warrants large scale production and justifies the high cost and risk involved in FDI as a mode of entry compared to exports.Originality/valueTo the best of authors' knowledge, this is the first attempt to deal with the relationship between home country exports and OFDI, for an important group of emerging market economies, i.e. BRICS. The understanding of this relationship allow us to identify whether factors contributing to OFDI from emerging economies are “tied” to their home economies thereby making exports necessary or are rather based on firm specific competencies which are leveraged in different locations to cater to expanding markets.
Gossip is a fearful thing: the impact of negative workplace gossip on knowledge hiding
Authors: Yao Zhu , Luo Jinlian , Zhang Xianchun 
Published: July 2020

PurposeThe crucial role of knowledge sharing in an organization has become even more crucial lately, resulting in garnering more attention by scholars. In reality, while several organizations expect their employees to share knowledge with colleagues actively, many choose to hide their knowledge when asked for help. This study aims to explore whether negative workplace gossip (NWG) affects employee knowledge hiding (KH), as well as analyzes whether relational identification (RI) and interpersonal trust (IT) play a chain mediating role between the two, and discusses whether forgiveness climate (FC) could be used as a boundary condition in the relationships mentioned above.Design/methodology/approachBased on the conservation of resource (COR) theory and the cognitive–affective personality system (CAPS) theory, the authors surveyed 326 employees in China at 2 time-points and explored the correlation between NWG and KH, as well as the underlying mechanism. Using confirmatory factor analysis, bootstrapping method and structural equation model, the authors validated the research hypotheses.FindingsThe findings revealed the following: NWG negatively correlates with KH; RI and IT play a mediation role between NWG and KH, respectively, and both variables also play a chain mediation role in the relationship mentioned above; and FC moderates the negative impact of NWG on RI, further moderating the chain mediation between RI and IT and between NWG and KH.Originality/valueFirst, this study established the correlation between NWG and KH, as well as analyzed the internal mechanism between the two. Besides, this study adds to scholars’ understanding of the underlying mechanisms by which these effects could occur. Second, this study demonstrated the moderating effect of FC – a situational feature that has been neglected in previous studies. Furthermore, this study can not only complement the situational factors ignored in previous studies but also broaden the application scope of CAPS. Finally, this study effectively combines COR and CAPS, which provides a basis for the application of these two theories in the future.
Research on the variable buyback contract
Authors: Liu Tianzhuo , Liu WangBo , Yang Feng 
Published: July 2020

Purpose
Based on the traditional buyback model, this paper aims to propose a new buyback method – the variable buyback contract – to solve the serious inventory backlog in the current economic situation.

Design/methodology/approach
In this paper, the authors further study the buyback problem in a two-level supply chain with uncertain demand. Such a problem can be found in many research papers, which also use the Stackelberg game model. They put forward many factors that affect the buyback price, including risk preference, random arrival of consumers, etc. Different from the existing research, the authors propose another factor that may affect supply chain buyback – the retailer's remaining inventory to study the buyback contract.

Findings
First, the authors found that under the variable buyback contract, there is an optimal retail price, wholesale price and an optimal range of parameter settings for the buyback price. Second, the proposed Pareto-optimal solution for system improvement can achieve supply chain coordination. Third, under some conditions, the variable buyback contract is better than the wholesale price contract and fixed-price buyback contract.

Originality/value
First, this is the first paper to discuss to measure the buyback price with the retailer's remaining inventory. Second, the proposed buyback contract can help decision-makers to choose the optimal improvement strategies. Third, this contract has a certain practical significance, which can effectively alleviate the current inventory backlog problem.
Flows of information and meaning: a vocabulary approach to integrated thinking and reporting
Authors: Quarchioni Sonia , Ruggiero Pasquale , Damiano Rodolfo 
Published: July 2020

PurposeIntegrated reporting (IR) is increasingly becoming a practice useful not only for accountability but also for managerial purposes because of its potential role as a signifying practice for integrated thinking (IT). In this perspective, this paper aims to explore which of the objects that are represented in integrated reports provide materiality and common understanding to the concept of IT for its effective implementation within organizations.Design/methodology/approachThis paper is based on a vocabulary approach for interpreting the texts of integrated reports as systems of words that are able to provide meaning for a common understanding of the concept of IT. In particular, by focusing on words and their relationships, the authors combine textual analysis and network text analysis to examine the structure of meaning embedded in the texts of integrated reports of five organizations, which serve as empirical cases for analysis during the period 2012-2018.FindingsThe concept of IT is dynamic in its meaning since in integrated reports it is represented by referring to different objects, in the case different types of capital (i.e. financial, human, social-relational, process, organizational and commercial), which are related to each other while following different paths over time. The dynamic nature of the meaning of IT affects the semantic orientation of the reports in a mutual relationship between IT (which conveys flows of information within the reports) and integrated reports (through which flows of meaning are made visible).Originality/valueThis paper opens the way to a linguistic approach for analyzing the different concepts related to IT to make them meaningful in creating (at least temporarily) a common understanding, as well as facilitating coordination within organizations and between organizations and their environment.
Adhering to lifestyle change recommendations via the trans-theoretical model: a mixed-methods study among type 2 diabetes patients
Authors: Nor Noraishah Mohamed , Sidek Suriati , Saad Nurulwahidah , Jaafar Nurul Hazirah , Mohd Shukri Nor Azwani 
Published: July 2020

Purpose
This paper aims to identify and explore the factors affecting type 2 diabetes mellitus (T2DM) patients' adherence to lifestyle change recommendations, with the guidance of the trans-theoretical model (stages of change).

Design/methodology/approach
This study was conducted in two parts. In Part A, 163 randomly selected participants were asked to complete a cross-sectional survey. Data regarding demographics, stages of change and levels of confidence to engage in lifestyle changes were collected. In Part B, in-depth interviews were conducted among 30 individuals, aged between 30 and 65 years, had been diagnosed with T2DM and had seen dietitian at least once. Purposive sampling was used to recruit participants with different sociodemographic characteristics.

Findings
Part A showed that most of the participants were in the pre-action group (60%), with a higher mean HbA1c (8.9%) as compared to the action group (40%) which had a mean HbA1c of 6.9%. Part B further revealed the pre-action group and action group identified four key themes concerning lifestyle changes adherence: stumbling block; self-care belief; knowledge implementation; and self-empowerment.

Practical implications
Health-care providers should identify patients' stages of change before lifestyle changes implementation.

Originality/value
This study highlighted that many factors might influence a T2DM patient's adherence to lifestyle change recommendations. Determining the stages of change and self-confidence of T2DM patients is needed to ascertain long-term adherence.
The dynamic dependence between the major US indices and the meat commodities indices
Authors: Derbali Abdelkader , Bouzgarrou Houssam 
Published: July 2020

PurposeThe purpose of this study is to examine empirically the conditional correlation between the major US indices (S&P500 index and Dow Jones Industrial index) and three selected meat commodities as: Feeder Cattle, Leen Hogs and Live Cattle during the period from July 22, 2010 to June 30, 2017.Design/methodology/approachIn this study, the authors use for the first time the GARCH-DECO (1,1) to examine empirically the conditional nexus between the major US indices (S&P500 index and Dow Jones Industrial index) and three selected meat commodities as; Feeder Cattle, Leen Hogs and Live Cattle during the period from July 22, 2010 to June 30, 2017.FindingsFrom the empirical findings, the authors conclude the existence of a highly significance of conditional heteroscedasticity parameters can demonstrate us to distinguish the nature of the volatility dependency between S&P500 index and Dow Jones Industrial index and three selected meat commodities indices.Originality/valueThis can find clear the significance of relationship in the process of financialization of the major US index and meat commodities indices in the case of this paper.