bluuebunny/crossref_metadata_2025_split huggingface dataset:
A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role forLINC00261in endocrine cell differentiation
Authors: Gaertner Bjoern , van Heesch Sebastiaan , Schneider-Lunitz Valentin , Schulz Jana Felicitas , Witte Franziska , Blachut Susanne , Nguyen Steven , Wong Regina , Matta Ileana , Hubner Norbert , Sander Maike 
Published: April 2020

AbstractLong noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can encode small proteins. The extent to which developmentally regulated lncRNAs are translated and whether the produced microproteins are relevant for human development is unknown. Here, we show that many lncRNAs in direct vicinity of lineage-determining transcription factors (TFs) are dynamically regulated, predominantly cytosolic, and highly translated during pancreas development. We genetically ablated ten such lncRNAs, most of them translated, and found that nine are dispensable for endocrine cell differentiation. However, deletion ofLINC00261diminishes generation of insulin+endocrine cells, in a manner independent of the nearby TFFOXA2. Systematic deletion of each ofLINC00261’s seven poorly conserved microproteins shows that the RNA, rather than the microproteins, is required for endocrine development. Our work highlights extensive translation of lncRNAs into recently evolved microproteins during human pancreas development and provides a blueprint for dissection of their coding and noncoding roles.Graphical AbstractHighlightsExtensive lncRNA translation and microprotein production during human pancreas developmentA small-scale loss-of-function screen shows most translated lncRNAs are dispensableLINC00261is highly translated and regulates endocrine cell differentiationDeletingLINC00261’s evolutionary young microproteins reveals no essential roles
ECS-based investigation of chloroplast ATP synthase regulation
Authors: Buchert Felix , Bailleul Benjamin , Joliot Pierre 
Published: April 2020

AbstractThe chloroplast ATP synthase (CF1Fo) contains a specific feature to the green lineage: a γ-subunit redox domain which contains a cysteine couple and interacts with the torque-generating βDELSEED-loop. Based on the recently solved structure of this domain, it was proposed to function as a chock.In vitro,γ-disulfide formation slows down the activity of the CF1Foat low transmembrane electrochemical proton gradient. Here, we utilizein vivoabsorption spectroscopy measurements for functional CF1Foactivity characterization in Arabidopsis leaves. The spectroscopic method allows us to measure thepresent in dark-adapted leaves, and to identify its mitochondrial sources. Furthermore, we follow the fate of the extragenerated by an illumination, including its osmotic and electric components, and from there we estimate the lifetime of the light-generated ATP. In contrast with a previous report [Joliot and Joliot, Biochim. Biophys. Acta, 1777 (2008) 676-683], the CF1Foγ-subunit exists mostly in an oxidized form in the dark-adapted state. To study the redox regulation of the CF1Fo, we used thiol agent infiltration in WT and a mutant that does not form the γ-disulfide. The obtained-dependent CF1Foactivity profile in the two γ-redox statesin vivoreconciles with previous biochemicalin vitrofindings [Junesch and Gräber, Biochim. Biophys. Acta, 893 (1987) 275-288]. The highest rates of ATP synthesis we measured in the two γ-redox state were similar at high. In the presence of the γ-dithiol, similar rates were obtained at a ~45 mV lowervalue compared to the oxidized state, which closely resembled the energetic gap of 0.7 ΔpH units reportedin vitro.
Population structure and genomic evidence for local adaptation to freshwater and marine environments in anadromous Arctic Char (Salvelinus alpinus) throughout Nunavik, Québec, Canada
Authors: Dallaire Xavier , Normandeau Éric , Mainguy Julien , Tremblay Jean-Éric , Bernatchez Louis , Moore Jean-Sébastien 
Published: April 2020

AbstractDistinguishing neutral and adaptive genetic variation is one of the main challenges in investigating processes shaping population structure in the wild, and landscape genomics can help identify signatures of adaptation to contrasting environments. Arctic Char (Salvelinus alpinus) is an anadromous salmonid and the most harvested fish species by Inuit people, particularly so in Nunavik (Canada), one of the most recently deglaciated region in the world. Unlike most other anadromous salmonids, Arctic Char occupy coastal habitats near their overwintering rivers during their marine phase. The main objective of this study was to document the putative neutral and adaptive genomic variation of anadromous Arctic Char populations in Nunavik (Québec, Canada) and bordering regions. A second objective was to interpret our results in the context of fisheries management in Nunavik. We used genotyping-by-sequencing (GBS) to genotype 18,112 filtered single nucleotide polymorphisms (SNPs) for 650 individuals sampled in 23 locations (average sample size per location = 28) along >2,000 km of coastline. Our results reveal a hierarchical genetic structure, whereby neighboring hydrographic systems harbour distinct populations grouping within major oceanographic basins, namely the Hudson Bay, Hudson Strait, Ungava Bay and Labrador Sea. We found genetic diversity and differentiation to be consistent with both the expected post-glacial recolonization history and patterns of isolation-by-distance reflecting contemporary gene flow. Furthermore, using three gene-environment association (GEA) methods we found genomic evidence for local adaptation to freshwater and marine environmental components, especially in relation to sea-surface and air temperatures during summer, as well as salinity. Our results support fisheries management at a regional level, and other implications on hatchery projects and adaptation to climate change are discussed.
Using text mining to track changes in travel destination image: the case of Macau
Authors: Liu Matthew Tingchi , Liu Yongdan , Mo Ziying , Ng Kai Lam 
Published: April 2020

PurposeTravel websites allow tourists to share their thoughts, beliefs and experiences regarding various travel destinations. In this paper, the researchers demonstrated an approach for destination marketing organisations to explore online tourist-generated content and understand tourists' perceptions of the destination image (DI). Specifically, the researchers initiated an investigation examining how the destination image of Macau changed during the period of 2014–2018 based on user-generated content on travel websites.Design/methodology/approachWeb crawlers developed by Python were employed to collect tourists' reviews from both Ctrip and TripAdvisor regarding the theme of “Macau attraction”. A total of 51,191 reviews (41,352 from Ctrip and 9,839 from TripAdvisor) were collected and analysed using the text-mining technique.FindingsThe results reveal that the frequency of casino-related words decreased in reviews by both international and mainland Chinese tourists. Additionally, international and mainland Chinese tourists perceive the DI of Macau differently. Mainland Chinese tourists are more sensitive to new attractions, while international tourists are not. The study also shows that there are differences between the government-projected DI and the tourist-perceived DI. Only the “City of Culture” and “A World Centre of Tourism and Leisure” have built recognition with tourists.Originality/valueGiven the easy accessibility of online information from various sources, it is important for destination marketing organisations to analyse and monitor different DI perspectives and adjust their branding strategies for greater effectiveness. This study uncovered the online DI of Macau by using text mining and content analysis of two of the largest travel websites. By analysing and comparing the differences and relationships among the frequently used words of tourist-generated content on these websites, the researchers revealed some interesting findings with important marketing implications.
An exploratory assessment of infrastructure resilience to disasters
Authors: Lee Dae Woong 
Published: April 2020

Purpose
This study aims to provide an analysis and evaluation of infrastructure resilience, one of the components of disaster resilience, to natural hazards.

Design/methodology/approach
The analysis of this study consists of four stages. First, descriptive statistical analyses were carried out on the soft and hard infrastructure resilience and natural hazard index. Second, the spatial data were visualized through the exploratory spatial data analysis to understand the spatial distribution and spatial characteristics of variables of the data. Third, the local indicators of the spatial association method were used to identify areas in clusters where infrastructure resilience is weak. Fourth, comparisons were made between the soft and hard infrastructure resilience and natural hazard index: the level of natural hazard is high but the soft and infrastructure resilience remain very vulnerable to disaster.

Findings
The study found that infrastructure resilience varies from community to community, particularly in the same community, in terms of hard infrastructure and soft infrastructure. In addition, the comparative analysis between infrastructure resilience and disaster risk levels resulted in communities that were likely to suffer greatly in the event of a disaster.

Originality/value
This study is meaningful in that infrastructure resilience of Korean local governments was discussed by dividing them into soft and hard infrastructure and comparing them to natural disaster risk levels. In particular, the comparison with the natural disaster risk level identified local governments that are likely to experience significant damage from the natural disaster, which is meaningful in that it serves as a basis for policy practitioners to actively build infrastructure and respond to disasters.
How can gamification be incorporated into disaster emergency planning? A systematic review of the literature
Authors: Kankanamge Nayomi , Yigitcanlar Tan , Goonetilleke Ashantha , Kamruzzaman Md. 
Published: April 2020

Purpose
The purpose of this paper is to investigate the role of gamification as a novel technique in motivating community engagement in disaster-related activities in order to address the question of how gamification can be incorporated into disaster emergency planning.

Design/methodology/approach
This study conducts a systematic literature review and explores available gamified applications for disaster emergency planning and their purpose of use. In total, 51 scholarly articles on the topic and 35 disaster-related gamified applications are reviewed.

Findings
The findings reveal the following: (a) gamified applications (n = 35) are used for education, research and intervention purposes; (b) gamified applications create new opportunities for community engagement and raise disaster awareness among the community in virtual environments; and (c) gamified applications help shape a new culture – i.e. gamified culture – that supports smart disaster emergency planning practice.

Originality/value
During the recent years, utilisation of game elements in non-game contexts – i.e., gamification – has become a popular approach in motivating people in various actions. Increasing research highlighted the benefits of gamification in enhancing community engagement, creating interactive environments, providing better behavioural outcomes and influencing democratic processes. Despite some of the applications indicating the potential of gamification in disaster emergency planning, the use of gamification technique in this discipline is an understudied area. This study reveals gamification can be incorporated into disaster emergency planning.
Supply chain agility: a systematic review of definitions, enablers and performance implications
Authors: Al Humdan Eias , Shi Yangyan , Behnia Masud , Najmaei Arash 
Published: April 2020

PurposeSupply chain agility (SCA) has recently received considerable attention in the literature and in practice. Despite its popularity, the concept of SCA seems to be vaguely defined and loosely structured. More specifically, definitional ambiguity and conceptual fragmentation have prevented the concept of SCA from reaching its full potential. The time is ripe to address these issues through a systematic literature review.Design/methodology/approachA review and synthesis of the literature on SCA was undertaken. The authors selected 56 top-tier related articles for further analysis after applying rigorous filtering procedures.FindingsThe results of the review confirm that several key themes surround SCA's definition and enablers. In addition, consensus needs to be reached in terms of its performance dimensions and measures. Accordingly, this study constructed an encompassing definition, scrutinized SCA enablers and outcomes and thus developed an original framework for SCA, providing a unique conceptual contribution. Several research directions were also addressed accordingly.Originality/valueThe novelty of this research lies in the selection of highly recognized publications. It also provides an encompassing definition of SCA, consolidates its enablers for better communication and synthesizes its performance implications.
The mechanism behind employee agreeableness and group performance ratings: a Pakistani study
Authors: Altaf Sara , Iqbal Muhammad Zahid , Prooijen Jan-Willem van , Ikramullah Malik 
Published: April 2020

PurposeThis study seeks to examine the links between employee agreeableness, group performance, and peers' perceptions of threat of retaliation, through relationship conflict.Design/methodology/approachIn a laboratory setting, 42 groups of undergraduate students (N = 182) from a Pakistani university were assigned to group projects to be completed within four months. Data collected from three different questionnaires at four different times and actual scores awarded by the course instructor to each group were used for the analyses. Based on rWG(J)and ICC(1), level 1 (182 students') data were aggregated to level 2 (groups), and then analysed using regression analysis followed by Preacher and Hayes' bootstrapping procedure.FindingsResults suggest that high agreeableness predicts group performance positively and peers' perceptions of threat of retaliation negatively. Moreover, relationship conflict among group members significantly mediates the agreeableness-group performance relationship. The above relationships may be sensitive to national culture.Research limitations/implicationsIn this study, groups were formed for a few months, whereas in real organizational life, workgroups are formed for different durations. Therefore, the range of situations to which these findings generalize remains an open question.Practical implicationsAgreeableness of group members can be constructive for performance of the group. Managers may utilize this insight while forming groups, and rating performance.Originality/valueThere is dearth of research illuminating how employee's personality traits affect group performance and appraisal ratings. The study tests the effects of employee agreeableness on: (1) group performance, as rated by supervisors; (2) the threat of retaliation, as perceived by peer raters; and (3) the mediating effect of relationship conflict.
Salient cultural transformations in the age of globalization: implications for business and management
Authors: Yeganeh Hamid 
Published: April 2020

PurposeThis paper aims at analyzing salient cultural transformations and their implications for business and management.Design/methodology/approachFirst, the interpretative approach is explained, and its adoption is justified. Then, seven major cultural transformations associated with globalization are identified and analyzed. Finally, business and management implications are discussed.FindingsThe cultural trends/transformations caused by or associated with globalization include convergence, divergence, hybridization, the clash of cultures/civilizations, diversity, multiculturalism, time-space compression, temporal acceleration, short-termism, risk, insecurity and uncertainty.Research limitations/implicationsThis study, like any other interpretative study, is limited in its internal validity. Furthermore, some scholars may have different perspectives on cultural transformations, such as clash of cultures, diversity, multiculturalism and risk society.Originality/valueAt the methodological level, this paper adopts an interpretative research design and takes into consideration historical, contextual and social components of culture. While the culture in management is often conceptualized as bipolar and mutually exclusive dimensions, this study offers a more versatile conceptualization of culture.
A systematic review of drivers and interventions against sex work migration in Edo State, Nigeria
Authors: Agwu Prince , Okoye Uzoma , Ekoh Prince , Chukwu Ngozi , Onalu Chinyere , Igwe Ijeoma , Onuh Paul , Amadi Gift , Nche George 
Published: April 2020

PurposeSex work migration involves a huge number of females from Nigeria, and has attracted concerns within and across the country. To add to ongoing conversations about responsible migration, our review underscores the prevalence of sex work migration in Edo State, Nigeria, the drivers and interventions.Design/methodology/approachThe review adopted exhaustive search terms coined with the aid of “Boolean Operators”. Search terms were entered into several search engines and databases to elicit peer-reviewed and grey literature within sex work migration and human trafficking for commercial sex. An output of 578 studies was recorded with 76 (43 academic papers and 33 grey literature) meeting the inclusion criteria.FindingsThe study acknowledged wide-spread prevalence of sex work migration involving Nigerian females who are largely from Edo State. It achieved a prioritization of the factors that drive sex work migration based on how frequent they were mentioned in reviewed literature: economic (64.4%), cultural (46%), educational (20%), globalization (14.5%) and political factors (13.2%). Several interventions were highlighted together with their several limitations which include funding, absence of grass-roots engagement, dearth of appropriate professionals, corruption, weak political will, among others. A combination of domestic and international interventions was encouraged, and social workers were found to be needful.Originality/valueOur systematic review is the first on this subject, as none was found throughout our search. It seeks to inform policy measures and programmes, as well as horizontal efforts poised to tackle the rising figures of sex work migrants and attendant consequences in Nigeria.
Scale development and validation for measuring business-to-business Wasta relationships
Authors: Berger Ron , Barnes Bradley R. , Silbiger Avi 
Published: April 2020

PurposeManagers of multinational enterprises (MNEs) from developed economies are often cautious to understand the cultural environment where they do business. This is predominantly true in developing economies, and even more so in certain Arab countries where MNEs have limited knowledge and experience. The purpose of this study is to report on the development of a research instrument that is applicable to Arab business culture, following the 2011 Arab Spring. The investigation draws on data from three different groups of people, i.e. leaders (business professors and leading politicians), business people and postgraduate business students, all of Palestinian nationality. The article examines the Arabic culturally based business structure called Wasta, a system that relies on social networks and the reciprocal exchange of favors. A research instrument is developed to measure three dimensions of Wasta across these three different groups of people and examines their influence on relationship satisfaction and organizational performance. The findings reveal that the groups are affected differently by these dimensions and see different utility in Wasta. Such insights may be useful for MNE practitioners when entering Arab countries, when seeking to employ younger Arabs and when partnering with Arab businesses or dealing with government officials.Design/methodology/approachResearch paperFindingsThis study has focused on the impact of Wasta on relationship satisfaction and on relationship performance for three different groups of individuals: business people, students and leaders. It was hypothesized that higher levels of each component of Wasta would contribute positively to relationship satisfaction, and that the latter would in turn lead to higher relationship performance. Findings generally supported these hypotheses with some variations among groups. Furthermore, it was predicted that the model would be relevant to all three groups, but would be structured differently reflecting their different views of business. The findings of this study help answer our research question about the socio-economic, cultural and political factors that influence the business process involving Arab and non-Arab business managers.Originality/valueOriginal paper
Regional small businesses’ personal and inter-firm networks
Authors: Sharafizad Jalleh , Brown Kerry 
Published: April 2020

PurposeThe purpose of this paper is to examine the role of personal and inter-firm networks and the elements that contribute to the formation and management of these networks for regional small businesses.Design/methodology/approachSemi-structured interviews were conducted with 20 small business owners located in regional areas.FindingsThe findings highlight key characteristics of regional small business owners’ networks. Findings indicated that participants relied strongly on their personal networks for business purposes. This study shows that while personal networks adapted and changed into informal inter-firm networks, weak-tie relations within inter-firm networks were unlikely to develop into close personal networks. Novel findings also include a preference for “regional interactions” and included regular collaboration with local business competitors. Although the participants used social media to manage their business through personal networks, results confirmed there was a lack of awareness of the benefits of inter-firm networks with businesses outside the local region.Originality/valueWhile it is acknowledged small business owners use personal and inter-firm connections to maintain and grow their business, there is a lack of research examining both of these networks in the same study. This research addresses this gap and presents five propositions as a useful direction for future research. This paper adds to the evolution of existing knowledge by expanding understanding of the formation of business networks and conditions of business trust relations within a regional context.