bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Femoral Offset Measurement Accuracy between Three-Dimensional-CT and X-ray in Developmental Dysplasia of the Hip Patients and Normal People
Authors: Han Qing , Xu Xinyu , Zhang Aobo , Chen Bingpeng , Qin Yanguo , Wang Jincheng 
Published: April 2020

Abstract
Background: Femoral offset (FO) is essential for the guidance of prosthesis choice in the Total Hip Arthroplasty (THA). In current clinical practice, X-ray is the primary method to measure FO. However, the X-ray measurement of FO has low accuracy, especially for DDH. In this study, three-dimensional (3D)-CT was conducted to provide more accurate measurements. Methods: 3D-CT and X-ray measurements of FO from 55 DDH patients and 60 normal volunteers were conducted twice by two osteoarticular surgeons. The inter- and intra-observer reproducibility was analyzed by intraclass correlation coefficient (ICC). The FO values measured by 3D-CT and X-ray were compared and the absolute value of the difference was recorded as the error value of X-ray. These values were analyzed by paired-sample t-test, independent-sample t-test and Dunnett's t-tests, p < 0.05 was considered to be significant. Results: Significant differences were founded between 3D-CT and X-ray in the FO measurements, the absolute values of these differences were 5.42 ± 4.66 mm in DDH patients and 3.74 ± 2.80 mm in normal people, which was regarded as the X-ray error values. According to 3D-CT measurement, the FO value of DDH patients (including Hartofilakidis-I, II, III) was lower than that of normal people. The FO value of Hartofilakidis-II DDH patients was lower than that of Hartofilakidis-I patients. Conclusion: 3D-CT is more precise than X-ray in the measurement of FO in DDH patients and normal people. The 3D-CT method should be recommended to measure FO for the choice of prosthesis in DDH patients before THA.
One-stage anterior focus debridement, interbody graft using titamium mesh cages, and anterior instrumentation and fusion in the surgical treatment of short segment thoracic tuberculosis with paraplegia
Authors: zhang huijun , lu zenghui , wei lin , ding chao , yang junsong 
Published: April 2020

Abstract
Purpose The purpose of this study was to evaluate the clinical efficacy of primary anterior debridement, bone graft fusion and internal fixation in the treatment of short segmental thoracic tuberculosis with paraplegia.Methods We performed a retrospective analysis of 16 adult patients with short segment thoracic spinal TB with paraplegia who underwent surgery between September 2013 to March 2017. All the 16 patients were treated using a single primary anterior debridement, bone graft fusion and internal fixation. Clinical manifestations, laboratory, neurological symptoms,bone fusion and imaging results were subjected to statistical analysis.Results All patients underwent operation successfully. The preoperative ESR and CRP level of all patients were 72.6 ± 27.5 mm/h and 75.7 ± 25.9 mg/L, which decreased to 15.9 ± 4.6 mm/h and 4.7 ± 2.0 mg/L at the final follow-up, respectively. The preoperative thoracic kyphosis angle were 30.7 ± 7.1°respectively. The corresponding postoperative angles were ameliorated significantly to 9.1 ±1.9°. During the follow-up, spinal paraplegia was significantly improved in all patients.The symptoms of chest and back pain were alleviated and disappeared at 1–6 months postoperatively.Patients were followed up for 24–48months (average, 35.6 ±9.6 months). Among 16 patients, no recurrence, and bone fusion was achieved at the final follow-up.Conclusion The clinical results of primary anterior debridement, bone graft fusion and internal fixation in the treatment of segmental thoracic tuberculosis with paraplegia were satisfactory.
Effects of 4 weeks of Lactobacillus plantarum 299v supplementation on nutritional status, enteral nutrition tolerance, and quality of life in cancer patients receiving home enteral nutrition – a double-blind, randomized, and placebo-controlled trial
Authors: Karolina Kaźmierczak-Siedlecka , Folwarski Marcin , Ruszkowski Jakub , Skonieczna-Żydecka Karolina , Szafrański Waldemar , Makarewicz Wojciech 
Published: April 2020

Abstract

BackgroundSeveral human trials have confirmed that Lactobacillus plantarum 299v (Lp299v) relief the gastrointestinal symptoms observed in patients with irritable bowel syndrome, such as nausea, vomiting, and diarrhoea. These symptoms are similar to those associated with home enteral nutrition and they affect nutritional status as well as patients’ quality of life.MethodsThe current double-blind, randomized, and placebo-controlled study included 35 cancer patients receiving home enteral nutrition. There were 2 groups of participants consuming either 2 × 1010 CFU of Lp299v (n = 21) or placebo (n = 14) for 4 weeks. The aims of this study were to determine the effect of Lp299v on nutritional status, enteral formula tolerance, and quality of life in cancer patients.ResultsAn increase in serum albumin concentration was significantly higher in the Lp299v group than in the placebo group at the endpoint (p = 0.032). Moreover, the changes in the frequency of vomiting and flatulence were significantly reduced at week 4 compared to baseline in the Lp299v group (p = 0.0117). The improvement of quality of life was observed in both groups; however, with no statistically significant differences between the analysed groups (p > 0.05).ConclusionsWe have demonstrated that administration of Lp299v in cancer patients receiving home enteral nutrition may improve laboratory parameters, predominantly the concentration of albumin, however, overall it does not have an impact on nutritional status. Lp299v may reduce the gastrointestinal symptoms related to enteral nutrition; notwithstanding, the improvement of quality of life may be the result of enteral nutrition rather than the effect of administration of Lp299v.Trial registration ClinicalTrials.gov (identifier: NCT03940768)
Aortic stiffness and central hemodynamics in treatment naïve HIV infection: A cross-sectional study
Authors: Martínez-Ayala Pedro , Alanis-Sánchez Guillermo Adrian , Gonzalez-Hernández Luz Alicia , Álvarez-Zavala Monserrat , Cabrera-Silva Rodolfo Ismael , Andrade-Villanueva Jaime Federico , Sánchez-Reyes Karina , Ramos-Solano Moisés , Castañeda-Zaragoza Diego Alberto , Cardona-Müller David , Tostuka-Sutto Silvia , Cardona-Muñoz Ernesto , Ramos-Becerra Carlos Gerardo 
Published: April 2020

Abstract
Background: Human immunodeficiency virus (HIV) infection is associated with a greater risk of cardiovascular disease (CVD). HIV infection causes a chronic inflammatory state and increases oxidative stress which can cause endothelial dysfunction and arterial stiffness. Aortic stiffness measured by carotid femoral-pulse wave velocity (cfPWV) and central hemodynamics are independent cardiovascular risk factors and have the prognostic ability for CVD. We assessed cfPWV and central hemodynamics in young individuals with recent HIV infection diagnosis not receiving antiretroviral therapy. We hypothesized that HIV individuals would present greater cfPWV and central hemodynamics (central systolic blood pressure and pulse pressure) compared to uninfected controls. Methods. We recruited 51 treatment naïve HIV individuals (HIV(+)) without previous CVD and 51 age- and sex-matched controls (HIV(-)). We evaluated traditional CVD risk factors including metabolic profile, blood pressure (BP), smoking, and immune state. Arterial stiffness and central hemodynamics were evaluated by cfPWV, central systolic BP and central pulse pressure (cPP) via applanation tonometry. Results. HIV(+) individuals presented a greater prevalence of smoking, reduced high density lipoprotein cholesterol, and body mass index. 65.9% of HIV(+) individuals exhibited lymphocytes <500 cell/µL. There was no difference in brachial or central BP between groups; however, HIV(+) individuals showed significantly lower cPP. We observed a greater cfPWV (mean difference= 0.5 m/s; p<0.01) in HIV(+) compared to controls, even after adjusting for heart rate, mean arterial pressure and smoking. Conclusion: In the early stages of infection, non-treated HIV individuals present a greater prevalence of traditional CVD risk factors, arterial stiffness, and normal or decreased central hemodynamics.
Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia
Authors: Amirfaiz Syed , Shahril Mohd Razif , Lua Pei Lin , Nurnazahiah Ali , Zakarai Nor Syamimi , Lok Ving , Ahmad Aryati , Sulaiman Suhaina 
Published: April 2020

Abstract
To date, limited data are available on metabolic syndrome (MetS) prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of MetS and abnormal MetS components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the MetS prevalence was 50.5%. Among those with MetS, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other MetS components were significantly different (p<0.05) between those with and without MetS. Significant differences between MetS and non-MetS groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). Otherwise, no significant difference was reported in other sociodemographic and clinical parameters between cancer survivors with and without MetS. In conclusion, MetS was highly prevalent among breast cancer survivors in this study, with weight, BMI, waist circumference, body fat percentage and cancer stages significantly affect MetS status.
Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study
Authors: Huang Chun-Jen , Shih Hung-Jen , Lin Ke-Hsun , Wen Yu-Ching , Fan Yen-Chun , Tsai Pei-Shan 
Published: April 2020

Abstract

Background: A high-cholesterol diet increases the risk of bladder cancer. This study investigated whether hyperlipidemia is a risk factor for bladder cancer.Methods: Data from Taiwan National Health Insurance Database were analyzed. The primary study end point was the occurrence of newly diagnosed bladder cancer. The relative risk of bladder cancer in a hyperlipidemia cohort was compared with that in an age- and gender-matched non-hyperlipidemia cohort.Results: Our data revealed that the hyperlipidemia cohort had a significantly higher subsequent risk of bladder cancer than did the non-hyperlipidemia cohort (adjusted hazard ratio [HR]=1.37, P=0.005) after propensity score adjustment. Subgroup analyses revealed that men in the hyperlipidemia cohort had a significantly higher subsequent risk of bladder cancer than did those in the non-hyperlipidemia cohort (adjusted HR=1.36, P=0.040). However, the risk of bladder cancer was not significantly different between women in the hyperlipidemia cohort and those in the non-hyperlipidemia cohort. Subgroup analyses further revealed that the risk of bladder cancer was significantly higher in men aged 20–39 years in the hyperlipidemia cohort than in those in the non-hyperlipidemia cohort (adjusted HR=5.45, P=0.029).Conclusions: Hyperlipidemia is a risk factor for bladder cancer in young adult men.
Estimation of Non-invasive Cuff-less Blood Pressure Using the Photoplethysmogram Signal
Authors: Rajagopal SureshKumar , Vairavan Manimegalai , Ramachandaran Dhanagopal 
Published: April 2020

Abstract

Background: This article presents a novel technique relating to the advancement of non-invasive cuff less blood pressure measurement using the PhotoPlethysmoGram (PPG) signals. The morphological characteristics of PPG signal have a strong correlation with the cardiovascular parameters and blood flow. The exact distinguishing feature of the PhotoPlethysmoGram signals is such as height as well as width of the pulse has considered into count for the measurement of blood pressure. In comparison to the existing measurement system like inflatable cuff and electrocardiogram units, this system only requires a pulse plethysomogram unit. The traditional blood pressure unit has many disadvantages such as expert personal, depends on the ability of the person to detect the korotkoff sounds, provides discomfort to the user and is not suitable for long time measurements. Moreover, this is very perceptive to artifacts owing to the existence of cuff. The PAT, PTT of the existing non-invasive techniques need many number of factors for estimation of blood pressure and are highly complex. Results: This method has intended for estimating the cardiovascular parameter of a non-invasive cuff-less blood pressure by utilizing the method of linear regression from PhotoPlethysmoGraphy signal. The real data has obtained using the GUI LabVIEW and further mathematical modelling of the obtained signal has performed by analysis using MATLAB tools. The obtained results had revealed that this technique is simple, non-invasive, cost-effective and consistent for estimating the arterial pulse signal in connection to variation in the amplitude of the waves. The exact distinguished feature of the PhotoPlethysmoGraphy signals like height and width of the pulse, which had considered into the count up for the measurement of blood pressure. The results obtained have been cross validating during the existing blood pressure monitors. Conclusions: The simulated output reveals the height of the pulse (systolic height) is inversely proportional to the systolic blood pressure as well as it rises for increasing cardiac output, however it occurs in less span of time. The pulse width and area is directly proportional to the systolic blood pressure. Our simulation result shows the specific relation between PPG and blood pressure. Error percentages as per the calculation among the extracted features have been less for inflection height ranging from ±10 to a min of ± 2.
mGlu3 receptor regulates microglial cell reactivity in neonatal rats
Authors: Zinni Manuela , Mairesse Jerome , Pansiot Julien , Fazio Francesco , Iacovelli Luisa , Orlando Rosamaria , Nicoletti Ferdinando , Vaiman Daniel , Baud Olivier 
Published: April 2020

Abstract
Background: Perinatal inflammation is a key factor of brain vulnerability in neonates born preterm or with intra-uterine growth restriction (IUGR), two leading conditions associated with brain injury and responsible for neurocognitive and behavioral disorders. Systemic inflammation is recognized to activate microglia, known to be the critical modulators of brain vulnerability. Although some evidence support a role for metabotropic glutamate receptor 3 (mGlu3 receptor) in modulation of neuroinflammation, its functions are still unknown in the developing microglia.Methods: We used a double-hit rat model of perinatal brain injury induced by a gestational low-protein diet combined with interleukin-1β injections (LPD/IL-1β), mimicking both IUGR and prematurity-related inflammation. The effect of LPD/IL-1β on mGlu3 receptor expression and the effect of mGlu3 receptor modulation on microglial reactivity were investigated using a combination of pharmacological, histological, and molecular approaches.Results: Exposure to LPD/IL-1β significantly down-regulated Grm3 gene expression in the developing microglia. Both transcriptomic analyses and pharmacological modulation of mGlu3 receptor demonstrated its central position in the control of inflammation in resting and activated microglia. Microglia hyper-reactivity to inflammatory challenge induced by LPD/IL-1β exposure was reduced by an mGlu3 receptor agonist. Conversely, both specific pharmacological blockade and siRNA knock-down of mGlu3 receptors in control microglia mimicked the pro-inflammatory phenotype observed in microglial cells exposed to LPD/IL-1β.Conclusions: Overall, these data show that Grm3 plays a central role in the regulation of microglial reactivity in the immature brain. Selective pharmacological activation of mGlu3 receptors may prevent inflammatory-induced perinatal brain injury.
Effect of sacral neuromodulation in patients with neurogenic bladder
Authors: Zheng Jianhong , Shi Wenxia 
Published: April 2020

Abstract

Background: Sacral neuromodulation (SNM) is widely used in patients with non-neurogenic overactive bladder and urinary retention but has only been applied recently for the management of the neurogenic bladder, and data are still scarce. Methods: This was a case series of patients who met the diagnosis of neurogenic bladder and received SNM between January 2016 and April 2019. Each participant received SNM. The evaluation of the participants' quality of life and urination diary (bladder symptom tracking form) included urine leaks, if urine pads need to be changed, urgent urination (0-5 points), urinary catheterization, and urinary output. The participants' expected values were analyzed. An effect >50% was considered effective. Results: All participants complied with the preoperative perineal floor exercise training. Among the 14 participants who underwent phase I SNM, one had no response at all and was excluded. After permanent electrode implantation, the urine output of one participant was similar to that of before surgery, and one participant had an incision infection, and the electrode was eventually removed. The postoperative follow-up after stage II SNM was 7.5±2.1 (range, 5-12) months. All 11 patients showed significant improvements in numbers of urination, urgency score, residual volume, and urination volume. The postoperative NEWS pain score was 1.6±0.9. Conclusions: Two-stage SNM can achieve satisfactory results in patients with neurogenic bladder. The key to success might lie in the correct and effective nursing and guidance throughout the perioperative management.
Association between Porphyromonas gingivalis and tumor-promoting status in esophageal squamous cell carcinoma
Authors: Chen Miao-Fen , Lu Ming- Shian , Hsieh Ching-Chuan , Chen Wen-Cheng 
Published: April 2020

Abstract

Background The microbiota is reported to affect tumor growth and the microenvironment of gastrointestinal cancers. However, the possible role of keystone bacterial infection in the development of esophageal squamous cell carcinoma (EsoSCC) remains unclear. In the present study, we studied the relationship between the oral microbiome, the periodontal pathogen Porphyromonas gingivalis (PG), and EsoSCC and elucidated the underlying mechanisms.Methods The microbiota in oral biofilms from patients was studied to identify bacterial biomarkers associated with EsoSCC by bioinformatics analyses. We then performed immunohistochemistry to examine the presence of PG in the esophageal tissues and analyze its relationship with the clinicopathologic characteristics in 156 EsoSCC patients. Furthermore, we investigated the role of PG infection in the progression of EsoSCC and its relationship with tumor microenvironment.Results The microbiota profiles from oral biofilms revealed that the abundance of PG was associated with a higher risk of developing EsoSCC. The presence of PG was detected immunohistochemically in 57% of cancerous tissues and was associated with a higher clinical stage and poor prognosis. Using cellular experiments and a 4-nitroquinoline 1-oxide (4NQO)-induced tumor animal model, the presence of PG was found to be associated with a higher risk of esophageal cancer. Increased IL-6 expression associated with an augmented epithelial-mesenchymal transition and recruitment of myeloid-derived suppressor cells were possible underlying mechanisms. Furthermore, in animal model including 4NQO-induced tumor and xenograft tumor model, we showed that the increased vitamin D3 induced by UVB light treatment obviously down-regulated IL-6 signaling and subsequently attenuated the increased risk of esophageal cancer induced by PG infection.Conclusions Our findings suggested that the presence of PG played an important role in the progression of esophageal cancer. Directly targeting PG or increasing vitamin D3 could be a promising strategy for the treatment of EsoSCC patients with PG infection noted by oral microbiota screening.
Influence of COL9A1 and COL19A1 Polymorphisms on Kaschin-Beck Disease Risk
Authors: He Xue , Zheng Jianwen , Yuan Dongya , Wang Yuhe , He Yongjun , Wang Li , Bai Mei , Jin Tianbo 
Published: April 2020

Abstract
Objective We aimed to determine whether COL9A1 and COL19A1 polymorphisms were associated with Kaschin-Beck disease (KBD) risk.Methods Five single nucleotide polymorphisms (SNPs) in COL9A1 and COL19A1 were genotyped in 316 KBD patients and 320 healthy controls. The association between genetic polymorphisms and KBD risk were assessed using logistic regression model by calculating odds ratio (OR) and 95% confidence interval (CI).Results After adjustment with age and sex, the frequency distributions of genotypes in rs3806093 and rs9346371 were significantly different between cases and controls. COL9A1 rs3806093 significantly increased KBD risk in co-dominant (OR = 14.80, p = 0.024) and recessive (OR = 16.39, p = 0.019) models. Meanwhile, COL9A1 rs555313 was associated with KBD risk in recessive model (OR = 3.80, p = 0.048).Conclusion COL9A1 and COL19A1 polymorphisms were associated with KBD risk in the Chinese Han population, suggesting roles of COL9A1 and COL19A1 in the development of KBD.
Determining whether age retirement for NBA players is associated with injuries and illnesses: A retrospective study
Authors: Chou Po-Hsin , Yeh Yu-Tsen , Wei Chien Tsai , Su Shih-Bin 
Published: April 2020

Abstract
Background: The careers of professional sport players are usually influenced by injuries and skills. The careers of all-star MBA and regular players depend on their health and how rapidly their skills diminish with age, respectively. Whether the above phenomena are considered and supported in the National Basketball Association (NBA) requires verification.Methods: We downloaded injury data from the NBA website in 2010–2018 and extracted all injury events (=9,783) involving 779 NBA players. Among these players, 705 were retired, 236 possessed all-star titles (60 injured and 170 non-injured), and 466 were regular players (408 injured and 58 non-injured) from 2010 to 2018. Both samples of retired all-star (n = 236) and regular players (n = 466) were compared to verify the effect of injury and illness on the retirement age using the bootstrapping method to estimate 95% confidence intervals in medians. We hypothesized that injuries and illnesses are associated with the retirement age of all-star players and irrelative to that of regular NBA players. Social network analysis(SNA) was performed to highlight the top three injuries with the highest degree centralities in their respective clusters.Results: We observed that the top three degree centralities include (1) sprained a left ankle, (2) sprained a right ankle, and (3) illness. The top two most injured NBA teams in 2010-2018, as obtained by the metrics for measurement, were Timberwolves (x-index = 32.86) and Hornets (x-index = 31.42). Most of the careers of NBA all-star players were affected by injuries/illnesses. The NBA careers of regular players were terminated mostly according to their skill.Conclusion: Although a number of things can be debated with regard to NBA, everyone can agree on one thing: Injuries are the worst. We confirmed that injuries and illnesses exhibit significant associations with the retirement age of all-star players and are irrelative to that of regular NBA players. Sports medicine is urgently needed to help players in preventing possible injuries while in the court in the discernable future.