bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physician and Hospital Utilization of P2Y12 Inhibitors in ST-Segment–Elevation Myocardial Infarction in the United States
Authors: Faridi Kamil F. , Garratt Kirk N. , Kennedy Kevin F. , Maddox Thomas M. , Secemsky Eric A. , Butala Neel M. , Yeh Robert W 
Published: March 2020

Background:
Ticagrelor and prasugrel are potent P2Y12 inhibitors with superior efficacy compared with clopidogrel among patients with ST-segment–elevation myocardial infarction (STEMI), though use in recent practice is not well described. In this retrospective study, we assessed trends, predictors, and variation in use of P2Y12 inhibitors in patients with STEMI in the United States.

Methods and Results:
We identified 169 505 STEMI patients in the Chest Pain-Myocardial Infarction Registry from October 2013 through March 2017. We determined national utilization rates of P2Y12 inhibitors at discharge, patient predictors for each medication, and variation in use between hospitals. In a subset of 9655 Medicare patients ≥65 years old, we compared 1-year adjusted risks of death, myocardial infarction, stroke, and bleeding based on hospital quartile of potent P2Y12 inhibitor use. Rates of ticagrelor use increased from 18.0% to 44.0%, while rates of prasugrel and clopidogrel use decreased from 24.6% to 13.5% and 57.4% to 42.6%, respectively. Prior percutaneous coronary intervention was the strongest clinical predictor for use of ticagrelor (adjusted odds ratio, 1.13 [95% CI, 1.09–1.18]) and prasugrel (adjusted odds ratio, 1.27 [95% CI, 1.21–1.34]) compared with clopidogrel. Predictors of clopidogrel use included no insurance, insurance with Medicare or Medicaid, and features associated with higher bleeding risk. The median hospital usage rate for newer P2Y12 inhibitors was 51.3% (interquartile range, 35.0%–65.9%), with substantial variation between hospitals (adjusted median odds ratio, 2.92 [95% CI, 2.77–3.10]). Among patients ≥65 years old, there were no differences in adjusted 1-year risks of adverse outcomes across hospital quartiles of potent P2Y12 inhibitor use.

Conclusions:
Almost one-half of STEMI patients by 2017 were discharged on ticagrelor while far fewer received prasugrel. Patient characteristics are associated with P2Y12 inhibitor selection, though substantial hospital variation exists. Identifying barriers to use of more potent P2Y12 inhibitors may improve patient-centered decision-making for STEMI patients.
Is the Concept of Animal Welfare Incompatible with Chinese Culture?
Authors: Cao Deborah 
Published: March 2020

Abstract
In discussions about nonhuman animal protection in China in recent years, one consistent theme is many people in China believe that animal welfare and the legal protection of animals are ahead of their time, and that animal welfare is a Western concept and practice, incompatible with Chinese culture. I argue that animal welfare is compatible with Chinese culture as seen through elements in Chinese traditional philosophy, imperial laws, and some idiomatic expressions in the Chinese language that are sympathetic toward animals. It is acknowledged that the realities in Chinese society have been very harsh as far as animals are concerned and much needs to be done in Chinese society to live up to some of the ideals espoused in Chinese culture and tradition. The grassroots animal protection efforts in China for the past ten years or so have been contributing positively and gaining traction in the right direction.
Body size variation in hybrids among populations of European water frogs (Pelophylax esculentus complex) with different breeding systems
Authors: Hermaniuk Adam , Czajkowska Magdalena , Borkowska Anetta , Taylor Jan R.E. 
Published: March 2020

Abstract
In some populations, hybrids reproduce with a parental species by eliminating the genome of this species from their own germline and produce gametes that only contain the genome of the other parental species (sexual host). This mode of reproduction, known as hybridogenesis, leads to a conflict of interest between the two parties because the sexual host should avoid mating with the hybrid to prevent a reduction in reproductive success, whereas the hybrid depends on such matings for survival. We investigated European water frogs (Pelophylax esculentus complex), including hybrids (P. esculentus, genotype LR) and two sexual host species (P. lessonae, LL and P. ridibundus, RR). We hypothesized that to maximize fitness, hybrid males should be morphologically more similar to the sexual host that is preferred by females for successful reproduction. To test this hypothesis, we compared hybrid males in two different population types, L-E (hybrids coexist with LL) and L-E-R (hybrids coexist with both LL and RR). The latter was described in terms of genome composition, sex ratio, and mate choice preferences; the sex ratio of hybrids was significantly male-biased. We found that LR males from the L-E-R populations were significantly larger than those from the L-E, which makes them more similar to P. ridibundus, the largest species within the P. esculentus complex. We suggest that a larger body size of hybrid males may provide a reproductive advantage in the L-E-R population type, where the most common type of pair caught in the breeding season was LR males × RR females.
Transnational Law Enforcement Cooperation – Fundamental Rights in European Cooperation in Criminal Matters
Authors: Luchtman Michiel 
Published: March 2020

Abstract
European cooperation in criminal matters is an area full of paradoxes. This article identifies the dominant narratives that define the nature of European cooperation in criminal matters. It also aims to identify the consequences that these narratives entail for the protection of fundamental rights in that cooperation and, subsequently, for the EU’s legislative agenda for the coming years. It develops a model of deeper justice integration, based on the narrative of a common European area, fostering the proper administration of criminal justice, transnational agency for individuals and fundamental rights.
The Legal Significance of Expert Treaty Bodies Pronouncements for the Purpose of the Interpretation of Treaties
Authors: Azaria Danae 
Published: March 2020

Abstract
Although it is widely accepted that the pronouncements of expert treaty bodies are not binding, this does not mean that they are deprived of any effect in law. This study focuses on their legal effects vis-à-vis the interpretation of treaties, and explores how the International Court of Justice and the International Law Commission have dealt with the pronouncements of expert treaty bodies in relation to the interpretation of treaties. The tale about the Court’s and the Commission’s approaches in this respect demonstrates the profound belief of both the Court and the Commission that international law is a legal system, which calls for reliance on the pronouncements of expert treaty bodies as integral actors within the legal system with some ‘authority’ concerning the determination of the law (within their mandate). This does not mean that the Court and the Commission support a ‘blind reliance’ on such pronouncements; rather the quality of each pronouncement is a criterion for relying on it. The reasoning of the Court and (and implicitly of) the Commission also shows that they consider that international law as a legal system, which necessitates ‘legal consistency’. This in turn suggests that the reliance on pronouncements of expert treaty bodies, which are mandated to supervise the application (and interpretation) of particular treaties, may constitute an exercise of ‘systemic integration’ which exceeds the confines of the rule set forth in Article 31(3)(c) of the Vienna Convention on the Law of Treaties.
The Developmentalist Project of the PT Governments: An Economic and Political Assessment
Authors: de Paula Luiz Fernando , Santos Fabiano , Moura Rafael 
Published: March 2020

An analysis of the endogenous and exogenous political and economic factors that conditioned the Partido dos Trabalhadores’s (PT) social-developmentalist project in 2003–2016 in the light of financialization and the “confidence game” conditioned by the volatility of external liquidity and commodities prices concludes that the first Lula administration faced the problem of a crisis of confidence and adopted orthodox policies but was able, with the improvement of international conditions, to launch policies of a more interventionist and distributive trend. Dilma Rousseff, facing a downright unfavorable international context, explicitly broke with the confidence game by applying the policy set of the new macroeconomic matrix. In her second term she radically reversed the policy orientation, moving toward a strong fiscal adjustment and monetary orthodoxy, and this eventually undermined her few sources of political support. The economic crisis from the second half of 2014 on undoubtedly contributed to the political crisis, which in turn made infeasible any attempt to implement policies to reverse the situation of economic crisis. Dilma’s impeachment finally interrupted the PT’s developmentalist project, allowing the emergence of new political actors. Uma análise dos fatores endógenos e exógenos, políticos e econômicos que condicionaram o projeto social-desenvolvimentista do Partido dos Trabalhadores (PT) em 2003–2016 à luz da financeirização e do “confidence game” condicionado pela volatilidade dos ciclos externos de liquidez e preços de commodities conclui que o primeiro governo Lula enfrentou o problema de crise de confiança e adotou políticas ortodoxas, mas pôde, com a melhoria nas condições internacionais, adotar políticas de perfil mais intervencionista e redistributivista. Já Dilma Rousseff, embora enfrentando contexto internacional francamente desfavorável, rompe explicitamente com o “confidence game” ao assumir o conjunto de políticas da Nova Matriz Macroeconômica. Na transição do primeiro para o segundo mandato, Dilma inverteu radicalmente a orientação das políticas, partindo para um forte ajuste fiscal e a ortodoxia monetária, o que acabou minando os poucos focos de sustentação política com os quais contava na sociedade. A crise econômica a partir do segundo semestre de 2014 sem dúvida contribuiu para dar origem à crise política, e esta por sua vez inviabilizou qualquer tentativa de implementação de políticas para reverter o quadro de crise econômica. O impeachment de Dilma, por fim, interrompe o projeto desenvolvimentista do PT, permitindo a emergência de novos atores políticos.
Offender trajectories, health and hospital admissions: relationships and risk factors in the longitudinal Cambridge Study in Delinquent Development
Authors: Skinner Guy CM , Farrington David P , Shepherd Jonathan P 
Published: March 2020

Objectives Research suggests that antisocial lifestyles constitute significant health risks. However, there are marked individual differences in the stability of antisocial behaviour. These different offending pathways may bear differential risks for adult health. Design Injury and illness data were collected prospectively in the longitudinal Cambridge Study in Delinquent Development. Setting Working-class inner-city area of South London. Participants Participants included the 411 men from the Cambridge Study in Delinquent Development, with interview data collected at ages 18, 32 and 48 years for each individual. Main outcome measures Organic illness, hospitalisation and injuries. Results By age 48, adjusted odds ratios showed that the incidence of organic illness was higher among Life-Course-Persistent, Late-Onset offenders and offenders in general. Based on adjusted odds ratios at age 32, the incidence of hospitalisations was higher for Late-Onset offenders. Adjusted odds ratios at age 48 also showed that the incidence of hospitalisations was higher for all three offender types and offenders in general. Our results also provide evidence that offenders were more likely to suffer injuries than non-offenders. Conclusions The findings of this study imply that preventing individuals from offending is likely to have substantial benefits for health.
Outcomes of outpatient total hip arthroplasty: a systematic review
Authors: Shapira Jacob , Chen Sarah L , Rosinsky Philip J , Maldonado David R , Lall Ajay C , Domb Benjamin G 
Published: March 2020

Introduction: Similar to other total joint arthroplasty procedures, total hip arthroplasty (THA) is shifting to an outpatient setting. The purpose of this study was to analyse outcomes following outpatient THA. Methods: A comprehensive literature search was performed in April 2019 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines using the PubMed, Embase, and Cochrane databases to identify articles that reported functional outcomes following outpatient total hip arthroplasty (THA). Results: 9 articles, with 683 hips and a collective study period of 1988 to 2016, were included in this analysis. The mean age across all studies was 58.9 years and the follow-up period ranged from 4 weeks to 10 years. 4 studies reported Harris Hip Scores (HHSs) for their patient populations and in 3 studies, the average HHSs were excellent (>90) by 6 weeks postoperatively. The fourth study reported fair HHS scores for the outpatient and inpatient THA groups (75 ± 18, 75 ± 14, p = 0.77, respectively) at 4 weeks postoperatively. VAS scores improved significantly in two studies and NRS at rest and during activity improved significantly ( p < 0.001) in a separate study. Overall, 88.1% of the enrolled patients were discharged the same day of surgery, as expected. Out of the 6 studies reporting on readmissions rate, there were two (0.34%) readmissions within 3 months of surgery. Conclusion: In patients with no significant comorbidities, outpatient THA leads to favourable outcomes as well as low readmission rates in the short term.
Arpe total joint arthroplasty for trapeziometacarpal osteoarthritis: 80 thumbs in 63 patients with a minimum of 10 years follow-up
Authors: Dumartinet-Gibaud Raphaëlle , Bigorre Nicolas , Raimbeau Guy , Jeudy Jérome , Saint Cast Yann 
Published: March 2020

In this retrospective study, we report a series of 80 Arpe prostheses for trapeziometacarpal osteoarthritis in 63 patients. Twenty-seven prostheses (20 patients) were lost to follow-up. Twenty-one were revised, eight of them during the first year after operation. The calculated cumulated implant survival rate was 85% at 10 years but could be lower due to the lack of information on the patients lost to follow-up. The number of complications due to technical errors was high; but after we had done 30 cases, the number of early revisions decreased markedly. At follow-up, 23 of 32 thumbs were totally free of pain, and the patients were satisfied with 31 thumbs. We conclude that the implant survival declines progressively in the long run, with a survival rate of 80% after 15 years of follow-up and a further decline thereafter. We also found that this surgery was difficult to master. We advise selecting this implant for thumb trapeziometacarpal osteoarthritis with caution. Level of evidence: IV
Serum soluble suppression of tumorigenicity‐2 level associates with severity of pulmonary hypertension associated with uncorrected atrial septal defect
Authors: Pratama Reza S. , Hartopo Anggoro B. , Anggrahini Dyah W. , Dewanto Vera C. , Dinarti Lucia K. 
Published: March 2020

Uncorrected atrial septal defect undergoes right ventricle chronic volume overload which may lead to pulmonary hypertension and Eisenmenger Syndrome. The soluble suppression of tumorigenicity‐2 is a left ventricle strain biomarker; however, its role in right ventricle strain is unclear. This study aimed to investigate the implication of serum soluble suppression of tumorigenicity‐2 in adult uncorrected atrial septal defect. This was a cross‐sectional study. We enrolled 81 adult uncorrected secundum atrial septal defect patients. Clinical and hemodynamic data were collected. Serum samples were withdrawn from the pulmonary artery during right heart catheterization. Serum soluble suppression of tumorigenicity‐2 and NT‐proBNP levels were measured. Subjects were divided into three groups based on clinical and hemodynamic severity. The correlation of soluble suppression of tumorigenicity‐2 with patients' data and comparison among groups were analyzed. A p value <0.05 was considered statistically significant. Results showed that, there were significant correlations between serum soluble suppression of tumorigenicity‐2 and mean pulmonary artery pressure (r = 0.203, p = 0.035) and right ventricle end‐diastolic diameter (r = 0.203, p <0.05). Median serum soluble suppression of tumorigenicity‐2 level was incrementally increased from group I (atrial septal defect and no‐pulmonary hypertension), group II (left‐to‐right atrial septal defect and pulmonary hypertension), to group III (Eisenmenger Syndrome): (17.4 ng/mL, 21.8 ng/mL, and 29.4 ng/mL, respectively). A post‐hoc analysis showed that serum soluble suppression of tumorigenicity‐2 level was significantly different between groups I and III (p = 0.01). Serum N terminal pro brain natriuretic peptide (NT‐proBNP) level was consistently associated with worse clinical and hemodynamic parameters. No correlation was found between serum soluble suppression of tumorigenicity‐2 and NT‐proBNP level. In conclusion, serum soluble suppression of tumorigenicity‐2 level had significant positive correlation with mean pulmonary artery pressure and right ventricle end‐diastolic diameter in uncorrected secundum atrial septal defect patients. Higher serum soluble suppression of tumorigenicity‐2 level was associated with the presence of pulmonary hypertension and Eisenmenger Syndrome in uncorrected secundum atrial septal defect patients.
High-Performance Quasi-2D Perovskite Light-Emitting Diodes Via Poly(vinylpyrrolidone) Treatment
Authors: Wang Zijun , Xu Xiaoqiang , Gao Lin , Yan Xingwu , Li Lu , Yu Junsheng 
Published: March 2020

AbstractIn this work, we fabricate poly(vinylpyrrolidone) (PVP)-treated Ruddlesden-Popper two-dimensional (quasi-2D) PPA2(CsPbBr3)2PbBr4 perovskite light-emitting diodes (PeLEDs) and achieved a peak brightness of 10,700 cd m−2 and peak current efficiency of 11.68 cd A−1, threefold and tenfold higher than that of the pristine device (without PVP), respectively. It can be attributed that the additive of PVP can suppress the pinholes of perovskite films owing to the excellent film-forming property, inhibiting the leakage current. Besides, PVP treatment facilitates the formation of compact perovskite films with defect reduction. Our work paves a novel way for the morphology modulation of quasi-2D perovskite films.
Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield
Authors: Han Ruicai , He Xunfeng , Pan Xiaohua , Shi Qinghua , Wu Ziming 
Published: March 2020

AbstractXanthine dehydrogenase (XDH) is an important enzyme in purine metabolism. It is involved in regulation of the normal growth and non-biological stress-induced ageing processes in plants. The present study investigated XDH’s role in regulating rice leaf senescence. We measured physical characteristics, chlorophyll content and fluorescence parameters, active oxygen metabolism, and purine metabolism in wild-type Kitaake rice (Oryza sativa L.), an OsXDH over-expression transgenic line (OE9), and an OsXDH RNA interference line (Ri3) during different growth stages. The expression patterns of the OsXDH gene confirmed that XDH was involved in the regulation of normal and abiotic stress-induced ageing processes in rice. There was no significant difference between the phenotypes of transgenic lines and wild type at the seedling stage, but differences were observed at the full heading and maturation stages. The OE9 plants were taller, with higher chlorophyll content, and their photosystems had stronger light energy absorption, transmission, dissipation, and distribution capacity, which ultimately improved the seed setting rate and 1000-seed weight. The opposite effect was found in the Ri3 plants. The OE9 line had a strong ability to remove reactive oxygen species, with increased accumulation of allantoin and alantoate. Experimental spraying of allantoin on leaves showed that it could alleviate chlorophyll degradation and decrease the content of H2O2 and malonaldehyde (MDA) in rice leaves after the full heading stage. The urate oxidase gene (UO) expression levels in the interference line were significantly lower than those in the over-expression line and wild-type lines. The allantoinase (ALN) and allantoate amidinohydrolase (AAH) genes had significantly higher expression in the Ri3 plants than the in OE9 or wild-type plants, with OE9 plants showing the lowest levels. The senescence-related genes ACD1, WRKY23, WRKY53, SGR, XERO1, and GH27 in Ri3 plants had the highest expression levels, followed by those in the wild-type plants, with OE9 plants showing the lowest levels. These results suggest that enhanced activity of XDH can regulate the synthesis of urea-related substances, improve plant antioxidant capacity, effectively delay the ageing process in rice leaves, and increase rice yield.
Mixture toxicity of zinc oxide nanoparticle and chemicals with different mode of action upon Vibrio fischeri
Authors: Chen Fen , Wu Ligui , Xiao Xiaoyu , Rong Lingling , Li Mi , Zou Xiaoming 
Published: March 2020

Abstract
Background
Zinc oxide nanoparticle (nZnO) and chemicals with different mode of action (MOA, i.e., narcotic and reactive) were frequently detected in the Yangtze River. Organisms are typically exposed to mixtures of nZnO and other chemicals rather than individual nZnO. Toxicity of nZnO is caused by the dissolution of Zn2+, which has been proved in the field of single toxicity. However, it is still unclear whether the released Zn2+ plays a critical role in the nZnO toxicity of nZnO–chemicals mixtures. In the present study, the binary mixture toxicity of nZnO/Zn2+ and chemicals with different MOA was investigated in acute (15 min) and chronic (12 h) toxicity test upon Vibrio fischeri (V. fischeri). The joint effects of nZnO and tested chemicals were explored. Moreover, two classic models, concentration addition (CA) and independent action (IA) were applied to predict the toxicity of mixtures.

Results
The difference of toxicity unit (TU) values between the mixtures of Zn2+–chemicals with those of nZnO–chemicals was not significant (P > 0.05), not only in acute toxicity test but also in chronic toxicity test. The antagonistic or additive effects for nZnO-chemicals can be observed in most mixtures, with the TU values ranging from 0.75 to 1.77 and 0.47 to 2.45 in acute toxicity test and chronic test, respectively. We also observed that the prediction accuracy of CA and IA models was not very well in the mixtures where the difference between the toxicity ratios of the components was small (less than about 10), with the mean absolute percentage error (MAPE) values ranging from 0.14 to 0.67 for CA model and 0.17–0.51 for IA model, respectively.

Conclusion
We found that the dissolved Zn2+ mainly accounted for the nZnO toxicity in the mixtures of nZnO–chemicals, and the joint effects of these mixtures were mostly antagonism and additivity. CA and IA models were unsuitable for predicting the mixture toxicity of nZnO–chemicals at their equitoxic ratios.