bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and validation of coronary heart disease risk prediction model for general hospitals in Tacheng Prefecture, Xinjiang, China
Authors: Xu Yikang , Ma Jingru , Yang Yang , Liu Limin , Zhao Xinran , Wang Yu , Mijiti Alimu , Cheng Qiangru , Ma Jun 
Published: December 2024

ObjectiveTo analyze the risk factors for coronary heart disease (CHD) in patients hospitalized in general hospitals in the Tacheng Prefecture, Xinjiang, and to construct and verify the nomogram prediction model for the risk of CHD.MethodsFrom June 2022 to June 2023, 489 CHD patients (CHD group) and 520 non-CHD individuals (control group) in Tacheng, Xinjiang, were retrospectively selected. Using a 7:3 ratio, patients were divided into a training group (706 cases) and a validation group (303 cases). General clinical data were compared, and key variables were screened using logistic regression (AIC). A CHD risk nomogram for Tacheng was constructed. Model performance was assessed using ROC AUC, calibration curves, and DCA.ResultsIn the training group, non-Han Chinese (OR = 2.93, 95% CI: 2.0–4.3), male (OR = 1.65, 95% CI: 1.0–2.7), alcohol consumption (OR = 1.82, 95% CI: 1.2–2.9), hyperlipidemia (OR = 2.41, 95% CI: 1.7–3.5), smoking (OR = 1.61, 95% CI: 1.0–2.6), diabetes mellitus (OR = 1.62, 95% CI: 1.1–2.4), stroke (OR = 2.39, 95% CI: 1.6–3.7), older age (OR = 1.08, 95% CI: 1.1–1.2), and larger waist circumference (OR = 1.04, 95% CI: 1.0–1.1) were the risk factors for coronary heart disease (all P &lt; 0.05). The area under the curve (AUC) of the work characteristics of the subjects in the training group and the validation group were 0.80 (95% CI: 0.8–0.8) and 0.82 (95% CI: 0.8–0.9), respectively. The Hosmer-Lemeshow test indicated P = 0.325 for the training group and P = 0.130 for the validation group, with calibration curves closely fitting the ideal curve. The predicted values aligned well with actual values, and decision curve analysis results suggest that the model offers a net clinical benefit.ConclusionThe CHD risk prediction model developed in this study for general hospitals in Tacheng Prefecture, Xinjiang, demonstrates strong predictive performance and serves as a simple, user-friendly, cost-effective tool for medical personnel to identify high-risk groups for CHD.
FSH/LH co-stimulation in Advanced Maternal Age (AMA) and hypo-responder patients – Arabian gulf delphi consensus group
Authors: Awwad Johnny , Peramo Braulio , Elgeyoushi Bohaira , Melado Laura , Salame Anastasia , Chawla Monika , Jibrel Salam , Detho Sajida , Al Rumaih Hazem , Tomsu Mustapha , Fahim Khaled , Abd-ElGawad Mohamed , Fouad Alaa , Humaidan Peter 
Published: December 2024

BackgroundIn a global effort to assess expert perspectives on the use of recombinant gonadotropins, recombinant human luteinizing hormone (r-hLH) and recombinant human follicle-stimulating hormone (r-hFSH), a consensus meeting was held in Dubai. The key aim was to address three critical questions: What are the factors that influence follicle response to gonadotropins? Which categories of patients are most likely to benefit from LH supplementation? And what are the optimal management strategies for these patients?MethodsA panel of thirty-six experts reviewed and refined the initial statements and references proposed by the Scientific Coordinator. Consensus was defined as agreement or disagreement by more than two-thirds (66%) of the panel members for each statement.ResultsThirty-five statements were formulated, of which thirty-one reached consensus. For patients with Hypo-Response to Gonadotropin Stimulation (20 statements), all identified risk factors, including advanced age, high BMI, and chronic conditions, achieved unanimous agreement. Diagnostic approaches, such as the inclusion of POSEIDON criteria and hormone level monitoring, were endorsed by the majority, with over 90% agreement. Management strategies, particularly individualized stimulation protocols and optimized scheduling, garnered broad consensus, with only one statement falling short of the threshold. Additionally, in cases of severe FSH and LH deficiency, combining r-hFSH with r-hLH was found to improve pregnancy rates and cost efficiency compared to human menopausal gonadotropin (hMG). For patients with Advanced Maternal Age (AMA) (15 statements), there was strong agreement on the use of oral contraceptive pills and estrogen priming. Recommendations concerning antagonist protocols and dosing of r-hLH and r-hFSH also achieved high levels of consensus. Significant agreement supported r-hLH supplementation and a tailored approach to luteal phase support. However, there were mixed opinions on the route of progesterone administration, with some experts expressing neutral or disagreeing views. Despite these differences, unanimous consensus was reached on markers of treatment success, particularly live birth rates, pregnancy rates, and embryo development, underscoring the importance of these outcomes in evaluating treatment efficacy.ConclusionThis consensus provides a practical clinical perspective to a wide range of global professionals on the strategies employed during key phases of Assisted Reproductive Technology (ART) treatment. To further improve outcomes, incorporating additional clinical insights on ART approaches, alongside existing guidelines and policies, may offer valuable guidance for optimizing patient care.
Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus
Authors: Cao Jianye , Du Tiantao , Li Jian , Chen Baiyu , Xie Xianting , Zhang Guoshu , Feng Jia , Xu Tao 
Published: December 2024

BackgroundLichen planus (LP), an autoimmune disorder, remains incompletely understood in terms of its etiological mechanisms. This study aims to elucidate causal relationships among immune cell populations, plasma metabolites, and lichen planus using Mendelian randomization (MR) techniques.MethodsEmploying a two-sample, two-step MR approach, with single nucleotide polymorphisms (SNP) serving as genetic instruments for both exposures and mediators, this study minimizes biases from confounding and reverse causality. Leveraging summary statistics from genome-wide association studies (GWAS) involving 731 immune cell traits (N = 3757), 1091 plasma metabolite traits (N = 8299), and lichen planus (N = 367668), inverse variance weighting (IVW) is adopted as the primary MR analytical method. The total effect of immune cells traits on LP is decomposed into direct and indirect effects mediated by plasma metabolites.ResultsMR analysis reveals causal associations for 28 immune cell traits and 38 plasma metabolites with LP (PIVW &lt; 0.05). Specifically, NK % lymphocyte shows a negatively correlated causal effect with LP (ORIVW = 0.952; 95% CI: [0.910, 0.995], PIVW= 0.030). Among mediators, Picolinate significantly contributes, explaining 16.4% (95% CI: [28.3%, 4.54%]) of the association between NK % lymphocyte and LP.ConclusionThese findings support a potential protective causal effect of NK % lymphocyte on LP, partially mediated by Picolinate levels. Thus, interventions targeting Picolinate levels may mitigate LP burden attributed to low NK % lymphocyte counts. This study provides new evidence and insights into the pathogenesis of lichen planus, advancing our understanding of its underlying mechanisms.
Prognostic significance of early alpha fetoprotein and des-gamma carboxy prothrombin responses in unresectable hepatocellular carcinoma patients undergoing triple combination therapy
Authors: Zhang Teng , Li Wengang , Chen Qian , He Weiping , Sun Jing , Li Dong , Wang Quan , Duan Xuezhang 
Published: December 2024

BackgroundRecent advancements in combination therapy for unresectable hepatocellular carcinoma (uHCC) have shown promise, but reliable serological prognostic indicators are currently lacking for patients undergoing triple combination therapy of stereotactic body radiation therapy (SBRT), immunotherapy, and targeted therapy. We aimed to investigate the prognostic significance of early alpha fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) responses in these patients.MethodsThis retrospective research included 115 uHCC patients treated with SBRT in combination with immunotherapy and targeted therapy (triple therapy) at our institution from April 2021 to December 2022. Participants were categorized into high AFP and high DCP cohorts based on baseline levels. AFP and DCP responses were defined as decreases from baseline of over 50% and 70%, respectively, according to ROC curve analysis. Differences in overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) were assessed between the tumor biomarker response and non-response groups.ResultsMultivariate analysis indicated that AFP or DCP response at 6-8 weeks post-therapy significantly influenced ORR (high AFP cohort: odds ratio [OR] 5.50, 95% CI 2.04-14.83, p=0.001; high DCP cohort: OR 7.99, 95%CI 2.82-22.60, p&lt;0.001). The median PFS was notably longer in tumor biomarker response groups (high AFP cohort: 13.7 vs 6.2 months, hazard ratio [HR] 0.36, 95% CI 0.20-0.62, p&lt;0.001; high DCP cohort: 15.6 vs 9.3 months, HR 0.44, 95% CI 0.26-0.74, p=0.002). AFP or DCP response was associated with prolonged OS (high AFP cohort: not reached vs. 21.9 months, HR 0.47, 95% CI 0.22-0.99, p=0.047; high DCP cohort: not reached vs. 20.6 months, HR 0.35, 95% CI 0.14-0.86, p=0.022).ConclusionAFP or DCP response at 6-8 weeks post-therapy predicts better oncological outcomes in patients with uHCC treated with triple therapy.
The effects of community-based education programs on empathy, emotional intelligence, and caring behaviors among nursing students: a scoping review
Authors: Jing Ma , Chui Pinglei , Chong Mei Chan , Maoting Tang 
Published: December 2024

IntroductionCommunity-based learning approaches are gaining recognition in nursing education as a means to address the needs of aging societies by fostering empathy, emotional intelligence, and caring behaviors among nursing students. These attributes are essential for enhancing the quality of care and building strong interpersonal connections with older adults. While community-based education programs offer promising benefits, there is still limited understanding of their impact on nursing students’ empathy, emotional intelligence, and caring behaviors. This scoping review aims to examine how community-based educational interventions can assist nursing students in developing these essential competencies, ultimately contributing to better outcomes in geriatric care.MethodA scoping review was conducted following the framework of Arksey and O’Malley. The following electronic databases were searched: Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, Web of Science, Psychology and Behavioral Sciences Collection, PubMed, and Google Scholar. Gray literature was also searched through Google Scholar and ProQuest. Studies included reports on nursing students’ emotional changes due to educational engagements with older adults.ResultsA total of 3,001 abstracts were screened, with 78 full texts reviewed, resulting in 9 studies being included in the analysis. The results demonstrate that interactions with older adults enhance nursing students’ empathy and emotional intelligence while fostering positive changes in their caring behaviors. Participants reported greater sensitivity to the feelings and physical discomforts of older adults, contributing to improved care and stronger relational dynamics.DiscussionCommunity-based education programs involving older adults represent an effective strategy for enhancing nursing students’ empathy, emotional intelligence, and caring behaviors, suggesting valuable implications for nursing education methodologies.
Revised taxonomic classification of the Stenotrophomonas genomes, providing new insights into the genus Stenotrophomonas
Authors: Yu Ze-Lin , Wang Rui-Bai 
Published: December 2024

BackgroundStenotrophomonas strains are important opportunistic pathogens with great potential applications in industry and agriculture. Their significant genetic and phenotypic diversity has led to several changes in their taxonomic localization and was prone to inaccurate species classification based on traditional identification methods.MethodsAll 2,615 genomes of the genus Stenotrophomonas were obtained from the NCBI genome database. Genomic methods, including average nucleotide identity (ANI), were used to evaluate the 31 defined species. After evaluating the ANI thresholds applicable to Stenotrophomonas, the species classification of all submitted genomes was revised.ResultsCompared to the reference genomes of each species, 41.17% of the submitted Stenotrophomonas genomes had ANI values below 95, and 8.58% of the genomes were even below 90%. Moreover, 45.3% (705/1555) of the S. maltophilia strains actually belonged to other species within the S. maltophilia complex (Smc), or even to distant relatives outside the Smc. Based on the ANI threshold values of 95 and 90% for species and complexes confirmed to be applicable to Stenotrophomonas, 2,213 submitted Stenotrophomonas genomes were re-divided into 116 ANI genome species.ConclusionThe results confirmed that 16S rRNA gene sequencing has low discriminability for the closely related Stenotrophomonas species. The annotated species of a considerable strain were indeed incorrect, especially since many S. maltophilia strains did not belong to this representative pathogenic species of Stenotrophomonas. This makes it necessary to reconsider the evolutionary relationship, pathogenicity, and clinical significance of Stenotrophomonas.
Short-term efficacy of right-to-left shunt closure in patients with vestibular migraine
Authors: Lang Yilin , Zhang Sai , Xie Peifan , Wang Yang , Wang Chuangwei , Wang Wenting , Zhu Xien , Gu Ping 
Published: December 2024

ObjectiveThis study aims to evaluate the short-term efficacy of right-to-left shunt closure in vestibular migraine patients, and compare the efficacy between patent foramen ovale (PFO) closure and pulmonary arteriovenous malformation (PAVM) embolization. Additionally, the study identifies factors related to surgical outcomes.MethodsForty-one patients with vestibular migraine and medium to large right-to-left shunts underwent surgery: PFO closure, PAVM embolization, or both. Baseline data and postoperative outcomes at one month, including migraine and dizziness frequency, duration, VAS, HIT-6, migraine scores, and DHI scores, were analyzed. The correlation between efficacy and baseline data was analyzed.ResultsAt one month postoperatively, the frequency and duration of dizziness and migraine attacks significantly decreased, and the VAS, HIT-6, migraine scores, and DHI scores all significantly dropped (p &lt; 0.001). There was no significant difference in the improvement rates of VAS, HIT-6, migraine scores, and DHI scores between the PFO group and the PAVM group (p &gt; 0.05). Red blood cell parameters positively correlated with the improvement rates of VAS, HIT-6, migraine scores, and DHI. This approach was more effective in male patients than in female patients (p &lt; 0.05).ConclusionRight-to-left shunt closure has a significant short-term effect on patients with vestibular migraine, regardless of the shunt location. Red blood cell parameters may serve as predictive indicators for the surgical efficacy in these patients.
Effects of fish oil supplementation on bone turnover markers in depression: a pilot study
Authors: Wang Feifei , Yuan Hui , Jin Kun , Tang Hui , Guo Jimin , Wang Chuan-Yue , Chen Jindong , Dong Fang , Wang Lu 
Published: December 2024

Background and objectiveThere is a close correlation between bone loss, depression, and antidepressants. N-3 PUFA supplementation has been considered an effective add-on therapeutic approach in ameliorating bone loss and relieving depression. However, the adjunctive effect of n-3 PUFA on bone metabolism in participants with depression is still unknown. This is a pilot study to investigate the dynamics of bone metabolism in depression and evaluate the efficacy of fish oil on bone loss in depression.MethodsIn this study, we focused on the change of bone turnover markers in depression, the effect of n-3 PUFA supplementation on bone turnover markers, and its association with clinical characteristics. A case–control study and a secondary analysis of a previously published randomized clinical trial (NCT03295708) that evaluates the efficacy of n-3 PUFA supplementation in venlafaxine-treated depressed participants have been included.ResultsThe levels of PINP (z = −2.233, p = 0.026) in depressed participants were significantly increased compared with healthy controls at baseline. The secondary analysis has shown significant differences exited on CTX (χ2 = 4.848, p = 0.028) and OSTEOC (χ2 = 6.178, p = 0.013) between n-3 PUFA and placebo group. The levels of CTX and OSTEOC (p &lt; 0.05) significantly decreased in the placebo group, which indicates that venlafaxine treatment reduces both bone formation and resorption markers. While the levels of OSTEOC and PINP were increased in the n-3 PUFA group (p &lt; 0.05). Moreover, the change in bone turnover markers showed consistency with clinical symptomatic outcomes.ConclusionParticipants with first-diagnosed, drug-naïve depression show active bone formation. Venlafaxine decreases bone remodeling, while n-3 PUFA increases bone formation, bringing light to preventing and treating bone loss in depression.Clinical trial registrationClinicalTrials.gov, NCT03295708.
Association of Fusobacterium nucleatum infection with colorectal cancer in Kazakhstani patients
Authors: Kulmambetova Gulmira , Kurentay Botakoz , Gusmaulemova Alua , Utupov Talgat , Auganova Dana , Tarlykov Pavel , Mamlin Meiram , Khamzina Saule , Shalekenov Sanzhar , Kozhakhmetov Arman 
Published: December 2024

ObjectivesFusobacterium nucleatum is a gram-negative anaerobic bacillus associated with colorectal cancer (CRC). We aimed to determine the abundance of F. nucleatum and other CRC-associated bacteria using quantitative real-time polymerase chain reaction (qPCR) analysis to detect the possible correlations between tumor and normal tissues and the relationships between patients’ clinical characteristics, diet, and CRC-associated bacteria.MethodsA total of 249 biopsy samples of tumor and paired normal tissues were collected from patients with CRC. Biopsy samples were screened for detection of F. nucleatum using qPCR targeting nusG gene. Bacteroides fragilis, Escherichia coli, and Streptococcus gallolyticus were also detected in the samples using species-specific genes.ResultsThe frequencies of detection of F. nucleatum in the tumor and normal tissues of patients with CRC were 43.37 and 24.1%, respectively (P &lt; 0.05). Statistical analysis using cycle threshold (Ct) values from qPCR data and clinical characteristics showed that tumor size, tumor location, and processed meat consumption were significantly correlated with the abundance of F. nucleatum (P &lt; 0.05). The significance of the prevalence of B. fragilis and E. coli in tumor tissues was marginally higher than that in normal tissues (P &lt; 0.1), and the consumption of processed/red meat affected the prevalence of these bacteria (P &lt; 0.05).ConclusionsOur results showed an association between the presence of F. nucleatum in tumor tissues and CRC, indicating that F. nucleatum may be a potential marker for CRC diagnosis. F. nucleatum is enriched in CRC tissues and is associated with CRC development.
GSTM1 null genotype underpins recurrence of NF2 meningiomas
Authors: Johnson Anthony C. , Tsitsikov Erdyni N. , Phan Khanh P. , Zuccato Jeffrey A. , Bauer Andrew M. , Graffeo Christopher S. , Hameed Sanaa , Stephens Tressie M. , Liu Yufeng , Dunn Gavin P. , Tsytsykova Alla V. , Jones Pamela S. , Dunn Ian F. 
Published: December 2024

IntroductionMeningiomas are the most common primary central nervous system (CNS) tumor in adults, comprising one-third of all primary adult CNS tumors. Although several recent publications have identified molecular alterations in meningioma including characteristic mutations, copy number alterations, and gene expression signatures, our understanding of the drivers of meningioma recurrence is limited.ObjectiveTo identify gene expression signatures of 1p-22q-NF2- meningioma recurrence, with concurrent biallelic inactivation of NF2 and loss of chr1p that are heterogenous but enriched for recurrent meningiomas.MethodsTranscriptomic alterations present in recurrent versus primary 1p-22q-NF2- meningiomas were identified using RNA sequencing (RNA-seq) data in a clinically annotated cohort.ResultsRecurrent 1p-22q-NF2- meningiomas were enriched for a newly identified GSTM1 null genotype compared to primary meningiomas that showed variable GSTM1 expression and independent external validation was performed.ConclusionsThe GSTM1 null genotype is a novel biomarker of 1p-22q-NF2- meningioma recurrence that resolves heterogeneity in existing meningioma subtypes and may be used to guide future clinical management decisions on extent of treatment to improve patient outcomes.
Prenatal echocardiographic diagnosis of a discontinuous left pulmonary artery with Taussig–Bing syndrome: a case report and literature review
Authors: He Yun , Yang Yufei , Song Xiaoyu , Zhang Zhonglei , Yan Dingfang , Xie Chao , Zeng Min , Zhang Wenjun 
Published: December 2024

BackgroundUnilateral pulmonary artery discontinuity (UPAD) is a rare fetal abnormality, for which a prenatal ultrasonographic diagnosis remains challenging. We report a case of left pulmonary artery discontinuity in association with Taussig–Bing syndrome, which has rarely been reported in the literature thus far.Case presentationA pregnant woman with a fetus with congenital heart disease (CHD) at 23 weeks gestation was referred to our center. She denied any familial history of genetic disorders in either spouse, and non-invasive prenatal testing (NIPT) also showed a low risk of CHD for the fetus. An ultrasound examination revealed a complex cardiac malformation indicative of left pulmonary artery discontinuity originating from the ductus arteriosus with Taussig–Bing syndrome. The family eventually chose to terminate the pregnancy and agreed to an autopsy, which confirmed that the prenatal echocardiographic diagnosis was correct. In addition, in this report, we review and analyze 17 reported cases of prenatal echocardiographic diagnoses of UPAD.ConclusionsUPAD is characterized by discontinuity between the proximal and distal pulmonary arteries, along with a ductal origin of the distal pulmonary artery. A discontinuous pulmonary artery originating from the ductus can be detected on prenatal sonography using ultrasound technology. The aim is to detect malformations earlier and carry out the necessary intervention measures as soon as possible.