bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic relationship between TSLP and IL‐33/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia
Authors: Huang Ruofei , Mao Wei , Wang Guoliang , Ding Jian , Sun Ying , Gao Gang , Dong Ping , Sun Zhenfeng 
Published: January 2020

BackgroundThe World Health Organization (WHO) has noted that allergic diseases are a major health problem of the 21st century. Allergic rhinitis (AR) is a type I allergic disease characterized by nasal mucosa and immune system abnormalities. AR is mediated by various inflammatory cells and is mainly characterized by altered secretion of cytokines. Thymic stromal lymphopoietin (TSLP) and the interleukin‐33/stimulation‐expressed gene 2 (IL‐33/ST2) signaling pathway are cytokines that play pivotal roles in many inflammatory responses and allergic reactions. There have been reports of interactions between the 2 pathways in many diseases. Hypoxia is a common pathologic manifestation of AR. The aim of this study was to explore the relationship and expressions and biologic functions of TSLP and IL‐33/ST2 in AR, and also to determine the effects of hypoxia on these cytokines.MethodsThe rat nasal mucosal epithelium was obtained from Wistar rats. Cells were cultured in groups under hypoxia and normoxia conditions. Identification of rat nasal epithelial cell (RNEpC) and protein expressions was done by immunohistochemistry and immunofluorescence methods. Cell proliferation and migration were examined using the cell counting kit‐8 (CCK‐8) and Transwell kit. Detection of apoptosis was tested using a fluorescence apoptosis kit. Enzyme‐linked immunoassay (ELISA) and Western blot analysis ELISA were used to measure cell secretion and protein expressions. For these experiments, TSLP was knocked down by lentivirus transfection and IL‐33 blocked with its antagonist.ResultsTSLP, IL‐33, and ST2 expressions were significantly higher in nasal mucosa epithelial cells from AR rats than in those from control rats. Hypoxia further promoted their expression. Increased TSLP and IL‐33/ST2 promoted cell proliferation, inhibited cell apoptosis, and enhanced cell migration. In addition, the downregulation of TSLP expression effectively attenuated expression of the IL‐33/ST2 axis and, through use of IL‐33 antagonists, could also reduce TSLP expression, a synergistic effect more obvious under hypoxia.ConclusionOur data indicate that TSLP and IL‐33/ST2 signaling pathways interact with each other in the pathogenesis and pathologic development of AR. TSLP inhibition is a key factor in AR treatment. Inhibiting hypoxia‐induced pathologic processes could represent a therapeutic effect by inhibiting IL‐33/ST2 expression via downregulating TSLP.
Subtle variations in the structure of crosslinked epoxy networks and the impact upon mechanical and thermal properties
Authors: Reyes Larry Q. , Zhang Jane , Dao Buu , Nguyen Duc L. , Varley Russell J. 
Published: January 2020

ABSTRACTPresented here is an investigation of the structure–property relationships of crosslinked networks using three bi‐functional glycidyl ether aromatic epoxy resins, two bi‐aryl and one tri‐aryl, cured with bi‐ and tri‐aryl amines. Subtle changes to the monomer chemistry including changing aromatic substitution patterns from meta to para, methylene to isopropyl and isopropyl to ether were explored. Changing an epoxy resin backbone from methylene to isopropyl enhances backbone rigidity thus increasing glass transition temperature (Tg), yield strength, and strain despite reducing modulus. Changing meta‐substitution to para increases Tg and yield strain while leaving strength unaffected and reducing modulus. Changing isopropyl linkages to ether reduces modulus, strength, Tg, and yield strain reflecting increased molecular flexibility. Using three instead of two aromatic rings increases the molecular weight between crosslinks thereby decreasing Tg and yield strain while increasing modulus and strength. Despite the complexities of multiple systems for varying epoxy resins and amine hardeners, the effect upon network properties is explained in terms of short‐ and long‐range molecular and segmental mobility, crosslink density, and equilibrium packing density. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48874.
Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases
Authors: Çelik Gonca , Arslan Tayfun , Şentürk Murat , Ekinci Deniz 
Published: January 2020

AbstractThe inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for the first time. The structures of the newly synthesized pyrazoline derivatives were characterized by Fourier transform‐infrared spectroscopy, 1H‐/13C‐nuclear magnetic resonance, and mass spectrometry, and elemental analysis. Compounds 1–6 showed Ki values in the range of 16.4–205.9 nM for hCA I and of 6.08–93.21 nM against hCA II. These hydroxyl and amino group‐containing compounds generally were competitive inhibitors. The compounds investigated here showed effective hCA I and II inhibitory effects, in the same range as the clinically used acetazolamide, and might be used as leads for generating enzyme inhibitors, possibly targeting other CA isoforms that have not yet been assayed for their interactions with such agents.
Nonparametric estimation of the cumulative incidences of competing risks under double truncation
Authors: de Uña‐Álvarez Jacobo 
Published: January 2020

AbstractRegistry data typically report incident cases within a certain calendar time interval. Such interval sampling induces double truncation on the incidence times, which may result in an observational bias. In this paper, we introduce nonparametric estimation for the cumulative incidences of competing risks when the incidence time is doubly truncated. Two different estimators are proposed depending on whether the truncation limits are independent of the competing events or not. The asymptotic properties of the estimators are established, and their finite sample performance is investigated through simulations. For illustration purposes, the estimators are applied to childhood cancer registry data, where the target population is peculiarly defined conditional on future cancer development. Then, in our application, the cumulative incidences inform on the distribution by age of the different types of cancer.
In situ green synthesis of highly fluorescent Fe2O3@CQD/graphene oxide using hard pistachio shells via the hydrothermal‐assisted ball milling method
Authors: Abdolrezaei Fatemeh , Sabet Mohammad 
Published: January 2020

AbstractIn this study, highly photoluminescent and photocatalytic Fe2O3@carbon quantum dots/graphene oxide nanostructures were synthesized using ball milling‐assisted hydrothermal synthesis with hard pistachio shells. Different analyses, such as X‐ray diffraction, energy dispersive X‐ray spectroscopy, and Fourier transform infrared spectroscopy were used to study the product structure. Scanning electron microscopy and transmission electron microscopy images were used to study product size and morphology. Optical properties of the as‐synthesized nanomaterials were investigated using ultraviolet–visible light and photoluminescence analyses. To increase photoluminescence intensity, ethylene diamine tetraacetic acid, polyethylene glycol, polyvinylpyrrolidone, and acetylacetonate anions were used to modify the product surface. Thermal stability of the product was studied using thermal gravimetric analysis. Finally, photocatalytic activity and surface adsorption of the product were investigated; the produce was found to be highly photoluminescent with high photocatalytic and surface activities.
Operational excellence in a green supply chain for environmental management: A case study
Authors: Kazancoglu Yigit , Sagnak Muhittin , Kayikci Yasanur , Kumar Mangla Sachin 
Published: January 2020

AbstractNowadays, organizations have started to become more conscious about the environment in their supply chain operations. The greening process has guided supply chain practices into new ways of thinking according to green standards. The assessment of the performance of green supply chain management (GSCM) requires a holistic view for the whole supply chain. In this context, given that becoming green in the operational side of activities is essential, the performance assessment of operational activities also requires a holistic view to be taken. In this paper, an attempt has been made to improve the performance of GSCM by examining and evaluating the green operational excellence of a hot dip galvanizing company. The framework includes several green operational excellence key criteria, namely, quality management, efficiency management, green production/manufacturing, eco‐packaging, and green design. First, the weights of the criteria and the respective measurements were found by fuzzy analytic network process. Then, the overall operational performance score was found by a weighted scoring method. Finally, both managerial and theoretical implications were suggested according to the outcomes and findings of the case study.
Process capability indices when two sources of variability present, a tolerance interval approach
Authors: Pusztai Éva , Kemény Sándor 
Published: January 2020

AbstractThe sound tolerance interval–based method and two Pp–based approximations are compared on the proportion of nonconforming parts. As output distribution of the process, one possible model is examined here: two sources of variations are in a one‐way structure. It was found that the uncertainty of variance components estimates plays the major role in the goodness of the three calculation methods.SummaryStatistical indices – like process capability (CP) or process performance (PP) index – make the relationship between the width of the specification interval and the extent of the process variability illustrative. The latter is characterized by the tolerance interval, which contains the major part of the population with high confidence. In the original concept this tolerance interval is calculated using oversimplified models. In practice this model is not conform with reality. As improvement two sources of variation is assumed in a one‐way structure.The proportion of non‐conforming parts of the population is the quantity of interest. Non‐conforming means that the characteristic is beyond the specification limits. According to this, the quantile of the distribution shall be determined that is equal to the specification limits. Thus, the task is to calculate the tolerance interval for the
distribution.In practical cases the variance components are unknown and are to be estimated. To estimate the ratio of non‐conforming parts, two approximate calculation methods which are coherent with the definition of PP are investigated, as well.The aim of this work is to compare the results of the two PP based approximate methods with the tolerance interval based (theoretically sound) calculation method. Two situations from the practice are considered – datasets from process validation and process monitoring environment are evaluated during which the effect of the number of experiments is given. Our study indicated that the main difference of the goodness of the approximations is from the uncertainty of parameter estimates.
Highly Efficient Singlet Oxygen Generators Based on Ruthenium Phthalocyanines: Synthesis, Characterization and in vitro Evaluation for Photodynamic Therapy
Authors: Ferreira Joana T. , Pina João , Ribeiro Carlos A. F. , Fernandes Rosa , Tomé João P. C. , Rodríguez‐Morgade M. Salomé , Torres Tomás 
Published: January 2020

AbstractInvited for the cover of this issue is the group of Torres at the University of Madrid. The image of the cover of this issue depicts cancer cells being destroyed by reactive singlet oxygen produced by ruthenium phthalocyanine glycoconjugates under red light. The work, developed at the Universities of Madrid, Aveiro, Lisbon and Coimbra, describes ruthenium phthalocyanines as powerful bladder cancer PDT agents. Read the full text of the article at 10.1002/chem.201903546.
Silicon Carbide Supported Palladium‐Iridium Bimetallic Catalysts for Efficient Selective Hydrogenation of Cinnamaldehyde
Authors: Li Penghui , Wang Yingyong , Wang Yunwei , Jin Guoqiang , Guo Xiang‐Yun , Tong Xili 
Published: January 2020

Summary of main observation and conclusionSelective hydrogenation of α,β‐unsaturated carbonyls into saturated carbonyls is important to obtain remunerative products. However, it is still a challenge to achieve high activity and selectivity under mild conditions. Herein, Pd, Ir and bimetallic Pd‐Ir nanoparticles were uniformly deposited with high dispersity on the surface of SiC by a facile impregnation method, respectively. The as‐prepared Pd/SiC catalysts efficiently hydrogenate cinnamaldehyde to hydrocinnamaldehyde at room temperature and atmospheric pressure, and the activity of Pd/SiC is observed further enhanced by adding Ir component (conversion of 100%). In addition, the dependence of Pd‐Ir catalyst activity on Pd/Ir molar ratio confirms a synergistic effect between Ir and Pd, which originates from the electron transfer between Pd and Ir.
Exponential Decay for the Near‐Critical Scaling Limit of the Planar Ising Model
Authors: Camia Federico , Jiang Jianping , Newman Charles M. 
Published: January 2020

AbstractWe consider the Ising model at its critical temperature with external magnetic field ha15/8 on the square lattice with lattice spacing a. We show that the truncated two‐point function in this model decays exponentially with a rate independent of a as a ↓ 0. As a consequence, we show exponential decay in the near‐critical scaling limit Euclidean magnetization field. For the lattice model with a = 1, the mass (inverse correlation length) is of order h8/15 as h ↓ 0; for the Euclidean field, it equals exactly Ch8/15 for some C. Although there has been much progress in the study of critical scaling limits, results on near‐critical models are far fewer due to the lack of conformal invariance away from the critical point. Our arguments combine lattice and continuum FK representations, including coupled conformal loop and measure ensembles, showing that such ensembles can be useful even in the study of near‐critical scaling limits. Thus we provide the first substantial application of measure ensembles. © 2020 The Authors. Communications on Pure and Applied Mathematics published by Wiley Periodicals LLC.
Validation of Fluorescence In Situ Hybridization (FISH) for Chromosome 5 Monosomy and Deletion
Authors: Zneimer Susan M. 
Published: January 2020

AbstractIn order to comply with regulations set by established local, state, and federal agencies and other regulatory organizations, such as the College of American Pathologists and the International Organization for Standardization, a clinical laboratory needs to develop procedures for the processes of validating laboratory‐developed tests (LDTs) and establishing performance specifications for these assays prior to use in clinical testing. This is applicable to all fluorescence in situ hybridization (FISH) assays. Even Food and Drug Administration–approved FISH assays must undergo some form of verification before implementation in the clinical laboratory. The process of validating an assay as an LDT must include a plan, a procedure, and a report. The validation studies described here include metaphase and interphase FISH methodology for identification of the LSI EGR1/D5S23, D5S721 dual‐color probe, which labels distinct biomarkers consistent with myeloid hematologic disorders, including myelodysplasias and acute myeloid leukemia. © 2020 by John Wiley & Sons, Inc.Basic Protocol 1: Validation plan for fluorescence in situ hybridization (FISH) probes for chromosome 5 monosomy and deletionSupport Protocol: Normal cut‐off calculationBasic Protocol 2: Validation procedure for FISH probes for chromosome 5 monosomy and deletionBasic Protocol 3: Validation report for FISH probes for chromosome 5 monosomy and deletion
Fractures in women with eating disorders—Incidence, predictive factors, and the impact of disease remission: Cohort study with background population controls
Authors: Frølich Jacob , Winkler Laura A. , Abrahamsen Bo , Bilenberg Niels , Hermann Anne P. , Støving René K. 
Published: January 2020

AbstractObjectiveMalnutrition and low weight in eating disorders (EDs) are associated with increased fracture risk compared to the general population. In a cohort study, we aimed to determine fracture rates compared to age and gender matched controls (ratio 5:1), assess the impact of disease remission on fracture risk, and establish predictive factors for fractures.MethodOf note, 803 ED patients referred to specialized ED treatment between 1994 and 2004 were included. In 2016, data on fractures were obtained through the Danish National Registry of Patients.ResultsFracture risk was increased in anorexia nervosa (AN; IRR 2.2 [CI 99%: 1.6–3.0]) but not in bulimia nervosa (BN; IRR 1.3, ns) or other specified feeding or eating disorders (OSFED; IRR 1.8, ns). IRR in the AN group were increased for vertebral fractures (IRR 3.8 [CI 99%: 1.4–10.3]), upper arm (IRR 3.0 (CI 99% 1.6–5.5) and hip (IRR 6.6 [CI 99%: 2.6–18.0]). Disease remission in AN is associated to lower fracture risk compared to active disease, but higher fracture risk compared to controls (IRR 1.7 [CI 99%: 1.1–2.7]).In regression analysis, age at debut of disease, nadir BMI and duration of disease before referral to treatment, independently predicted fracture.DiscussionWe confirm increased fracture risk in AN, and show significant differences in fracture risk between patients in disease remission and patients with active disease. Furthermore, we show that age at debut of disease and duration of disease before referral to treatment is positively correlated to fracture risk, whereas nadir BMI is negatively correlated to fracture risk.
Mesophication in temperate Europe: A dendrochronological reconstruction of tree succession and fires in a mixed deciduous stand in Białowieża Forest
Authors: Spînu Andreea P. , Niklasson Mats , Zin Ewa 
Published: January 2020

AbstractThe shift from shade‐intolerant species to shade‐tolerant mesophytic species in deciduous and mixed forests of the temperate zone is well described in studies from North America. This process has been termedmesophicationand it has been linked to changes in fire regime. Fire suppression results in the cessation of establishment of heliophytic, fire‐dependent tree species such as oak (Quercus) and pine (Pinus). Due to the scarcity of old‐growth forests in Europe, data on long‐term compositional changes in mixed forests are very limited, as is the number of studies exploring whether fire played a role in shaping the dynamics.The aim of this study was to reconstruct tree succession in a 43‐ha natural mixed deciduous forest stand in Białowieża Forest (BF), Poland using dendrochronological methods. In addition, the presence of aboveground fire legacies (charred and fire‐scarred deadwood) enabled the fire history reconstruction.Dendrochronological data revealed tree establishment (Quercus) back to the end of the 1500s and fires back to 1659. Under a regime of frequent fires until the end of the 18th century, only oak and pine regenerated, sporadically. A shift in the fire regime in the first half of the 19th century triggered oak and pine cohort regeneration, then gradually spruce (Picea) encroached. Under an increasingly dense canopy and less flammable conditions, regeneration of shade‐tolerantCarpinus,Tilia,andAcerbegan simultaneously with the cessation of oak and pine recruitment.Synthesis. The study reports the first evidence of mesophication in temperate Europe and proves that fire was involved in shaping the long‐term dynamics of mixed deciduous forest ecosystems. Our data suggest that fire exclusion promoted a gradual recruitment of fire‐sensitive, shade‐tolerant species that inhibited the regeneration of oak and pine in BF.
Left atrial function in heart failure with preserved ejection fraction: a systematic review and meta‐analysis
Authors: Khan Muhammad Shahzeb , Memon Muhammad Mustafa , Murad Mohammad H. , Vaduganathan Muthiah , Greene Stephen J. , Hall Michael , Triposkiadis Filippos , Lam Carolyn S.P. , Shah Amil M. , Butler Javed , Shah Sanjiv J. 
Published: January 2020

ABSTRACTAimsLeft atrial (LA) mechanical function may play a significant role in the development and progression of heart failure with preserved ejection fraction (HFpEF). We performed a systematic review and meta‐analysis to evaluate association of impaired LA function with outcomes in HFpEF.Methods and resultsMultiple databases were searched for original studies measuring different phases of LA function in HFpEF patients. Comparative LA function between HFpEF patients and healthy controls was assessed by pooling weighted mean differences (WMD). Adjusted hazard ratios (HRs) with 95% confidence intervals were pooled to evaluate the prognostic utility of LA function. Twenty‐two studies (2 trials, 20 observational) comprising 1974 HFpEF patients and 751 healthy controls were included. HFpEF patients had decreased LA reservoir [WMD = −12.21% (−15.47, −8.95); P < 0.001], LA conduit [WMD = −5.68% (−8.56, −2.79); P < 0.001], and pump [WMD = −11.07% (−14.81, −7.34); P < 0.001] emptying fractions compared with controls. LA reservoir [WMD = −13.38% (−16.07, −10.68); P < 0.001], conduit [WMD = −4.09% (−6.77, −1.42); P = 0.003], and pump [WMD = −3.53% (−4.47, −2.59); P < 0.001] strains were also significantly lower in HFpEF patients. Decreased LA reservoir strain [HR 1.24 (1.02, 1.50); P = 0.03] was significantly associated with risk of composite all‐cause mortality or heart failure hospitalization.ConclusionsImpaired LA function appears to have diagnostic and prognostic value in HFpEF, but whether indices of LA function truly refine discrimination for diagnosis or prognosis remains to be fully determined. Larger studies are needed to better evaluate associations between LA function and clinical outcomes and the role of LA function as a target for novel HFpEF therapies.
Front Cover Image, Volume 1, Number 5, December 2019
Authors: Farcet Jean‐Baptiste , Kindermann Johanna , Karbiener Michael , Kreil Thomas R. 
Published: January 2020

imageThe cover image is based on the Research Article Development of a Triton X‐100 replacement for effective virus inactivation in biotechnology processes by Jean‐Baptiste Farcet, Johanna Kindermann et al., https://doi.org/10.1002/eng2.12078.