bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of serum cytokine clusters associated with outcomes in ovarian clear cell carcinoma
Authors: Yabuno Akira , Matsushita Hirokazu , Hamano Tetsutaro , Tan Tuan Zea , Shintani Daisuke , Fujieda Nao , Tan David S. P. , Huang Ruby Yun-Ju , Fujiwara Keiichi , Kakimi Kazuhiro , Hasegawa Kosei 
Published: October 2020

AbstractSerum cytokine and chemokine networks may reflect the complex systemic immunological interactions in cancer patients. Studying groups of cytokines and their networks may help to understand their clinical biology. A total of 178 cases of ovarian cancer were analyzed in this study, including 73 high-grade serous (HGSC), 66 clear cell (CCC) and 39 endometrioid carcinomas. Suspension cytokine arrays were performed with the patients’ sera taken before the primary surgery. Associations between each cytokine and clinicopathological factors were analyzed in all patients using multivariate linear regression models, and cluster analyses were performed for each histotype. In the multivariate analyses, twelve of 27 cytokines were correlated with histotypes. Cluster analyses in each histotype revealed 2 cytokine signatures S1 and S2 in HGSC, and similarly C1 and C2 in CCC. Twenty-two of 27 cytokines were commonly clustered in HGSC and CCC. Signature S1 and C1 included IL-2,6,8,15, chemokines and angiogenic factors, whereas signature S2 and C2 included IL-4,5,9,10,13, TNF-α and G-CSF. Four subgroups based on a high or low level for each signature were identified, and this cluster-based classification demonstrated significantly different progression-free and overall survivals for CCC patients (P = 0.00097 and P = 0.017).
Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study
Authors: Huang Sheng-Han , Wang Chun-Chieh , Wei Kuo-Chen , Chang Cheng-Nen , Chuang Chi-Cheng , Chen Hsien-Chih , Lin Ya-Jui , Chen Ko-Ting , Pai Ping-Ching , Hsu Peng-Wei 
Published: October 2020

AbstractSingle-session stereotactic radiosurgery (SSRS) is recognized as a safe and efficient treatment for meningioma. We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with 245 tumors treated with radiosurgery between March 2006 and June 2017were retrospectively evaluated. Of these, 147 (64.5%) patients were treated with SSRS. The remaining 81 patients (35.5%) were treated with a fractionated technique. Protocols to treat meningioma were classified as 12–16 Gy per fraction for SSRS and 7 Gy/fraction/day for three consecutive days to reach a total dose of 21 Gy for FSRT. In univariate and multivariate analyses, tumor volume was found to be associated with local control rate (hazard ratio = 4.98, p = 0.025). The difference in actuarial local control rate (LCR) between the SSRS and FSRT groups after propensity score matching (PSM) was not statistically significant during the 2-year (96.86% versus 100.00%, respectively; p = 0.175), 5-year (94.76% versus 97.56%, respectively; p = 0.373), and 10-year (74.40% versus 91.46%, respectively; p = 0.204) follow-up period. FSRT and SSRS were equally well-tolerated and effective for the treatment of intracranial benign meningioma during the10-year follow-up period.
Continued smoking and posterior vitreous adhesion in the elderly evaluated on swept-source optical coherence tomography
Authors: Toyama Taku , Hashimoto Yohei , Kawai Hisashi , Azuma Kunihiro , Shiraya Tomoyasu , Araki Fumiyuki , Sugimoto Koichiro , Watanabe Yutaka , Hirano Hirohiko , Fujiwara Yoshinori , Ihara Kazushige , Kim Hunkyung , Kato Satoshi , Numaga Jiro , Obuchi Shuichi , Ueta Takashi 
Published: October 2020

AbstractIn this cross-sectional study including 1150 eyes of 681 volunteers ≧ 65 years old without retinal pathology, factors affecting the progression of posterior vitreous detachment (PVD) were investigated.
PVD stages were diagnosed based on swept-source optical coherence tomography (SS-OCT). Linear mixed effect model was used to determine whether age, gender, diabetes mellitus (DM), hypertension (HT), dyslipidemia (DL), and smoking status were associated with various stages of PVD. As a result, the multivariable analysis disclosed that the associations between older age and higher PVD stages (estimate [95% CI], 0.031 [0.020 to 0.042]; P < 0.0001), and current smokers and lower PVD stages (estimate [95% CI], − 0.24 [− 0.43 to − 0.056]; P = 0.011) were statistically significant. In contrast, female gender was not an independent factor affecting PVD stages in the elderly. Our analysis indicated that higher PVD stages observed in female eyes may be due to confounding effect, in which current smokers were predominantly males (i.e., 12.6% among males vs. 3.9% among females, P < 0.0001). In conclusion, our findings suggest that continuous smoking is associated with an adherent vitreoretinal interface in the elderly.
Veteran trees are a source of natural enemies
Authors: Wetherbee Ross , Birkemoe Tone , Sverdrup-Thygeson Anne 
Published: October 2020

AbstractPredation of invertebrate pest by natural enemies is a critical contribution of nature to people, because invertebrate pests cause a vast amount of economic damage and pesticides use has many long-term costs. Veteran trees are keystone structures and hotspots for biodiversity, and are a potential source of natural enemies. To explore this, we used a balanced experimental design where we measured predatory beetle diversity and attack marks on three colors of artificial caterpillars placed around 20 veteran oaks and 20 nearby young oaks, in Southern Norway. We predicted that around the veteran oaks there would be a greater diversity of predatory beetles and more invertebrate attacks on artificial caterpillars. Sampling for predatory beetles was conducted in summer 2017 and 2018, and invertebrate attacks were measured in 2018. We found support for the predictions: diversity of predatory beetles was higher around veteran trees and there were more arthropod attack marks on artificial caterpillars placed around veteran trees. Our results indicated that veteran trees are a source of natural enemies. Valuing and protecting veteran trees and their communities is an essential step towards a more sustainable system of management that has the possibility of promoting both the wellbeing of people and biodiversity.
Improved forecasts of atmospheric rivers through systematic reconnaissance, better modelling, and insights on conversion of rain to flooding
Authors: Lavers David A. , Ralph F. Martin , Richardson David S. , Pappenberger Florian 
Published: October 2020

AbstractAtmospheric rivers lie behind many extreme precipitation and flood episodes in the mid-latitudes. Better forecasts of atmospheric rivers and their impacts could help with preparedness. Here we argue that a comprehensive and systematic observational campaign could help advance numerical weather prediction, and thereby provide a path towards much improved forecasts of atmospheric rivers. We envision an interdisciplinary European–American observational campaign in the North Atlantic to identify and address numerical weather prediction errors in atmospheric rivers, and the associated extratropical cyclones. Insights gained could be applied in other regions. With improved understanding of the physiography of river basins and insights into their flood response to extreme precipitation, the impacts of atmospheric rivers can also be forecast more reliably.
The Devil in the Details Can Be Hard to Spot: Malapropisms and Children With Hearing Loss
Authors: Lowenstein Joanna H. , Nittrouer Susan 
Published: October 2020

Purpose
Better auditory prostheses and earlier interventions have led to remarkable improvements in spoken language abilities for children with hearing loss (HL), but these children often still struggle academically. This study tested a hypothesis for why this may be, proposing that the language of school becomes increasingly disconnected from everyday discourse, requiring greater reliance on bottom-up phonological structure, and children with HL have difficulty recovering that structure from the speech signal.

Participants
One hundred nineteen fourth graders participated: 48 with normal hearing (NH), 19 with moderate losses who used hearing aids (HAs), and 52 with severe-to-profound losses who used cochlear implants (CIs).

Method

Three analyses were conducted.
#1:
Sentences with malapropisms were created, and children's abilities to recognize them were assessed.
#2:
Factors contributing to those abilities were evaluated, including phonological awareness, phonological processing, vocabulary, verbal working memory, and oral narratives.
#3:
Teachers' ratings of students' academic competence were obtained, and factors accounting for those ratings were evaluated, including the five listed above, along with word reading and reading comprehension.

Results

#1:
Children with HAs and CIs performed more poorly on malapropism recognition than children with NH, but similarly to each other.
#2:
All children with HL demonstrated large phonological deficits, but they were especially large for children with CIs. Phonological awareness explained the most variance in malapropism recognition for children with CIs. Vocabulary knowledge explained malapropism recognition for children with NH or HAs, but other factors also contributed.
#3:
Teachers rated academic competence for children with CIs more poorly than for children with NH or HAs, and variance in those ratings for children with CIs were primarily explained by malapropism scores.

Conclusion
Children with HL have difficulty recognizing acoustic–phonetic detail in the speech signal, and that constrains their abilities to follow conversations in academic settings, especially if HL is severe enough to require CIs.

Supplemental Material

https://doi.org/10.23641/asha.13133018
Clinical Characteristics and Genotype–Phenotype Correlation in Children with KMT2E Gene-Related Neurodevelopmental Disorders: Report of Two New Cases and Review of Published Literature
Authors: Sharawat Indar Kumar , Panda Prateek Kumar , Dawman Lesa 
Published: October 2020

AbstractBackground In recent years, many new candidate genes are being identified as putative pathogenic factors in children with developmental delay and autism. Recently, heterozygous mutations in the KMT2E gene have been identified as a cause of a unique neurodevelopmental disorder with variable combination of global developmental delay or isolated speech delay, intellectual disability, autistic features, and seizures.Methods Here, we present two new cases of KMT2E mutation-associated neurodevelopmental disorder in a 4-year-old girl and 5-year-old boy. We also performed a pooled review of the previously published cases of KMT2E-related neurodevelopmental disorder. Articles were identified through search engines using appropriate search terms.Results Along with the presented 2 cases, 40 cases were analyzed. Out of them, 30, 6, and 4 children had protein-truncating mutations, missense mutations, and copy number variants, respectively. The common features were global developmental delay (97%) followed by macrocephaly (35%), seizures (30%), and autism (25%). Children with missense variants had severe phenotype, with microcephaly, profound developmental delay, and increased frequency of seizures. Neuroimaging revealed nonspecific changes, including cerebral white matter signal abnormalities.Conclusion KMT2E-related neurodevelopmental disorder remains one of the clinical differentials in children with global developmental delay and/or autistic features/seizure. With the reporting of more cases in the future, the already heterogeneous clinical spectrum of this disease is likely to be widened.
Policy Statement on Clinical Informatics Fellowships and the Future of Informatics-Driven Medicine
Authors: Kannry Joseph , Smith Jeff , Mohan Vishnu , Levy Bruce , Finnell John , Lehmann Christoph U. ,   on behalf of the Clinical Informatics Program Directors Group-AMIA
Published: October 2020

AbstractBoard certified clinical informaticians provide expertise in leveraging health IT (HIT) and health data for patient care and quality improvement. Clinical Informatics experts possess the requisite skills and competencies to make systems-level improvements in care delivery using HIT, workflow and data analytics, knowledge acquisition, clinical decision support, data visualization, and related informatics tools. However, these physicians lack structured and sustained funding because they have no billing codes. The sustainability and growth of this new and promising medical subspecialty is threatened by outdated and inconsistent funding models that fail to support the education and professional growth of clinical informaticians. The Clinical Informatics Program Directors' Community is calling upon the Centers for Medicare and Medicaid Services to consider novel funding structures and programs through its Innovation Center for Clinical Informatics Fellowship training. Only through structural and sustained funding for Clinical Informatics fellows will be able to fully develop the potential of electronic health records to improve the quality, safety, and cost of clinical care.
Women’s Cardiac Health in 2020: A Systematic Review
Authors: Sozzi Fabiola B. , Belmonte Marta , Schiavone Marco , Canetta Ciro , Gupta Rakesh , Blasi Francesco 
Published: October 2020

AbstractAlthough substantial progress has been made toward improving gender- and sex-specific cardiovascular disease (CVD) management and outcomes, contemporary reports indicate a persistent knowledge gap with regard to optimal risk-stratification and management in female cardiac heart disease (CHD) patients. Prominent patient and system delays in diagnosing CHD are, in part, due to the limited awareness for the latent CVD risk in women, a lack of sex-specific thresholds within clinical guidelines, and subsequent limited performance of contemporary diagnostic approaches in women. Several traditional risk factors for CHD affect both women and men. But other factors can play a bigger role in the development of heart disease in women. In addition, little is known about the influence of socioenvironmental and contextual factors on gender-specific disease manifestation and outcomes. It is imperative that we understand the mechanisms that contribute to worsening risk factors profiles in young women to reduce future atherosclerotic CVD morbidity and mortality. This comprehensive review focuses on the novel aspects of cardiovascular health in women and sex differences as they relate to clinical practice and prevention, diagnosis, and treatment of CVD. Increased recognition of the prevalence of traditional cardiovascular risk factors and their differential impact in women, as well as emerging nontraditional risk factors unique to or more common in women, contribute to new understanding mechanisms, leading to worsening outcome for women.
Core values of genomic citizen science: results from a qualitative interview study
Authors: Guerrini Christi J. , Trejo Meredith , Canfield Isabel , McGuire Amy L. 
Published: October 2020

AbstractGenomic citizen science initiatives that promote public involvement in the study or manipulation of genetic information are flourishing. These initiatives are diverse and range from data donation studies, to biological experimentation conducted in home and community laboratories, to self-experimentation. Understanding the values that citizen scientists associate with their activities and communities can be useful to policy development for citizen science. Here, we report values-relevant data from qualitative interviews with 38 stakeholders in genomic citizen science. Applying a theoretical framework that describes values as transcendent beliefs about desirable end states or behaviors that can be categorized according to the motivational goals they express and the interests they serve, we identified nine core values of genomic citizen science: altruism, autonomy, fun, inclusivity, openness, reciprocity, respect, safety, and solidarity.
Language skills and labour market returns
Authors: Ridala Svetlana 
Published: October 2020

Abstract
Increased migration, global trade and the introduction of digital labour platforms call for a better understanding of the
mechanisms that can enhance economic and labour market outcomes in the face of increasing disparities in culture, language and identity. The
article contributes to the literature on labour market returns on language skills, which is very heterogeneous and context-specific, by
carrying out a systematic review of that literature. The meta-regression analysis estimates the returns on language skills that come from
socio-economic, institutional and ethnolinguistic factors along with controls for the study design. The meta-regression results for the
labour market returns that stem from knowledge of the local state language, a significant local minority language or the business
language provide evidence that knowing the more influential language is associated with higher labour market rewards. Linguistic diversity
has a negative effect on the returns to skills in the business language but increases the returns to the local state language. Urbanisation
has a negative, though quantitatively modest, effect on returns to language skills in the business language, whilst the GDP level increases
the returns to minority language skills and unemployment increases returns to skills in the business language and the local state
language.
Plyometric training increases gross motor coordination and associated components of physical fitness in children
Authors: de Almeida Marcelus Brito , Leandro Carol Góis , Queiroz Daniel da Rocha , José‐da‐Silva Marivânio , Pessôa dos Prazeres Thaliane Mayara , Pereira Gleybson Maciel , das‐Neves Gabriela Silva , Carneiro Renata Cecília , Figueredo‐Alves Amanda Dayanne , Nakamura Fábio Yuzo , Henrique Rafael dos Santos , Moura‐dos‐Santos Marcos André 
Published: October 2020

AbstractThere is only limited evidence to suggest that training during childhood produces greater adaptations than at other ages. The aim of this study was to examine the effects of plyometric training (12 weeks, twice/week, 20 min/day) on physical fitness (PF) and gross motor coordination (GMC) in schoolboys aged 7–9 years. A total of 116 boys were assigned to two groups: plyometric training group (PT,n = 73) and control group (CG,n = 43). The CG maintained their normal daily activities. The PT consisted of twice‐weekly exercises on nonconsecutive days for twelve weeks under monitored and controlled conditions. PF (handgrip strength, standing long jump (SLJ), curl‐ups, sit and reach, square‐test, running speed, and 1 mile run test), GMC, Korper‐koordinations‐test fur Kinder (KTK), and body mass index (BMI) were assessed. The main results through a 2 × 2 (time × groups) repeated measures analysis variance demonstrated a significant time effect that improves PF and GMC according to the direction of the measure. A group effect was observed only in the abdominal strength test (CG = 12.06% and PT = 17.04%) and moving sideways (CG = 11.1% and PT = 12.4%) showing that independent of the group there was an improvement. A significant interaction effect (time × groups) was observed in the flexibility test (CG = −2.7% and PT = 3.5%) and STJ (CG = 3.1% and PT = 18.5%), as well as jumping sideways (CG = 16.3% and PT = 17.4%) and overall GMC score (CG = 9.8% and PT = 15.9%), showing that gains in these variables were greater in the PT group. The results suggest that 12 weeks of PT improve components of gross motor coordination and health‐related physical fitness in children.
Sources of information pick‐up for anticipation by skilled cricket batsmen
Authors: Müller Sean , Brenton John , Mansingh Akshai 
Published: October 2020

AbstractThis study investigated whether skilled West Indian cricket batsmen could use contextual and kinematic information to anticipate the type of ball being bowled. Thirty‐one participants were recruited that formed first class (n = 10), elite club (n = 10), and elite youth representative (n = 11) groups. Each group completed a video temporal occlusion batting test under two conditions. Condition one presented bowler kinematic information; that is, occlusion occurred at back‐foot, front‐foot, and ball release, with a no occlusion control. Condition two presented game contextual information in the form of field placings that was congruent with the ball types prior to temporal occlusion trials. Results revealed no significant skill group differences in the timing of information pick‐up under kinematic or contextual conditions. Prediction accuracy for all skill groups was at guessing level at each temporal occlusion that presented kinematic information, but was above chance at no occlusion. Prediction accuracy for all skill groups increased to above guessing level at advance cue temporal occlusions when contextual information was provided. Findings indicate that this group of skilled batsmen did not use kinematic information for anticipation in this temporal occlusion task, but relied heavily upon contextual information. An implication of this study is that skilled batsmen should be targeted for visual‐perceptual training to pick‐up contextual and kinematic information to guard against deception from the latter that can negatively impact batting performance.
Modeling of space charge dynamics in polyethylene under AC stress based on bipolar charge transport model
Authors: Cai Xinjing , Lin Xin , Yu Jianli , Lu Zhiwei 
Published: October 2020

Abstract
Space charge dynamics under AC stress is of importance as a majority of high voltage cables are under AC stress, and space charge is the driving mechanism of dielectric degradation under these conditions. Bipolar charge transport model is used to simulate space charge dynamics in polyethylene under AC stress. The current density, electroluminescence intensity and space charge density under sinusoidal, triangular and square voltages are compared. It is found that there is no phase shift between current density, electroluminescence intensity and applied voltages, which disagrees the results of Baudoin et al. The thickness of space charge layer under AC stress is much thinner that under DC stress.
Study on the interaction mechanism in the Pr–Fe–As system
Authors: He Lihua , Huang Run , Luo Jinxiao , Lv Xiaodong , Mao Juncheng , Zhang Jinzhu 
Published: October 2020

Abstract
The influence of different heat preservation temperatures on the interaction in the Pr–Fe–As ternary system and the principle for generating the interaction products of the Pr–Fe–As ternary system were studied by metallographic microscopy, scanning electron microscopy, and x-ray diffraction. Results showed that the α-Fe with As (i.e., the compound formed when the solubility of As in Fe exceeds the maximum solubility), Fe2As, PrAs, and a small amount of Fe17Pr2 were the main products when the atomic ratio of Pr: As is 1:3 and heat preservation for 20 h at 1173 K, 1223 K and 1273 K. PrAs decreased as the temperature increased, while the α-Fe with As decreased as the temperature decreased, and Fe2As increased gradually as α-Fe with As decreased. In the Pr–Fe–As ternary system, the diffusion of Pr is mainly short-range diffusion and double vacancies, and the PrAs develops in the margin of the penetration region, preventing the diffusion of As in Fe.