bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Polymeric Janus Superstructures via a Facile Synthesis Method
Authors: Lim Yi Guang Jerome , Low Hui Ying Jessalyn , Loo Say Chye Joachim 
Published: May 2020

AbstractPolymeric Janus particles can be exploited for a myriad of applications. Through the understanding of interfacial tensions, theragnostic agents such as drugs or nanomaterials can be successfully encapsulated into Janus particles without losing their anisotropic structure. In this work, it is reported that how Janus superstructures, as a further extension of the Janus morphology, can be obtained by blending other synthesis parameters into the solvent emulsion process, while adhering to the requirements of the Harkin's spreading coefficient (HSC) theory. Designing such unique structures for drug delivery can provide a broader range of possibilities and applications beyond conventional Janus particles.
Selective Bond Cleavage in Informational Poly(Alkoxyamine Phosphodiester)s
Authors: Cavallo Gianni , Clément Jean‐Louis , Gigmes Didier , Charles Laurence , Lutz Jean‐François 
Published: May 2020

AbstractThe collision‐induced dissociation (CID) of sequence‐defined poly(alkoxyamine phosphodiester)s is studied by electrospray ionization mass spectrometry. These informational polymers are synthesized using three different nitroxide building blocks, namely proxyl‐, SG1‐, and TEMPO‐derivatives. For a polymer containing TEMPO‐ and SG1‐based main chain alkoxyamines, it is found that both types of alkoxyamines break in CID tandem mass spectrometry (MS/MS). However, SG1‐sites are preferentially cleaved and this predominance can be increased by reducing collision energy, even though selective bond fragmentation is not observed. On the other hand, for a polymer containing proxyl‐ and SG1‐alkoxyamines, selective bond cleavage is observed at all studied collision energies. The SG1‐alkoxyamines can be first cleaved in MS/MS conditions and secondly the proxyl‐alkoxyamines in pseudo‐MS3 conditions. These results open up interesting new avenues for the design of readable, erasable or programmable informational polymers.
Effects of COVID‐19 on Parkinson's Disease Clinical Features: A Community‐Based Case‐Control Study
Authors: Cilia Roberto , Bonvegna Salvatore , Straccia Giulia , Andreasi Nico Golfrè , Elia Antonio E. , Romito Luigi M. , Devigili Grazia , Cereda Emanuele , Eleopra Roberto 
Published: May 2020

AbstractThe impact of coronavirus disease 2019 (COVID‐19) on clinical features of Parkinson's disease (PD) has been poorly characterized so far. Of 141 PD patients resident in Lombardy, we found 12 COVID‐19 cases (8.5%), whose mean age and disease duration (65.5 and 6.3 years, respectively) were similar to controls. Changes in clinical features in the period January 2020 to April 2020 were compared with those of 36 PD controls matched for sex, age, and disease duration using the clinical impression of severity index for PD, the Movement Disorders Society Unified PD Rating Scale Parts II and IV, and the nonmotor symptoms scale. Motor and nonmotor symptoms significantly worsened in the COVID‐19 group, requiring therapy adjustment in one third of cases. Clinical deterioration was explained by both infection‐related mechanisms and impaired pharmacokinetics of dopaminergic therapy. Urinary issues and fatigue were the most prominent nonmotor issues. Cognitive functions were marginally involved, whereas none experienced autonomic failure. © 2020 International Parkinson and Movement Disorder Society
New approach design of compact tri‐band microstrip bandpass filter based on combined stepped‐impedance resonator and triangular patches
Authors: Karimi Gholamreza , Rostaie Pegah , Sabaghi Fatemeh 
Published: May 2020

AbstractIn this article, a compact microstrip tri‐band bandpass filter based on a rectangular ring resonator (RRR) and two triangular patch resonators is presented. This filter is designed to operate at 3.5, 5.2, and 8 GHz for WiMAX, wireless local area network (WLAN), and satellite applications respectively. Also, the center frequencies of the first and second passband can be flexibly controlled by tuning the dimensions of RRR. The fabricated triband band pass filter has merits of compact size, low insertion loss, and suitable stopband. Good agreement between simulated and measured results is observed.
Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities
Authors: Andrews Jinsy A. , Berry James D. , Baloh Robert H. , Carberry Nathan , Cudkowicz Merit E. , Dedi Brixhilda , Glass Jonathan , Maragakis Nicholas J. , Miller Timothy M. , Paganoni Sabrina , Rothstein Jeffrey D. , Shefner Jeremy M. , Simmons Zachary , Weiss Michael D. , Bedlack Richard S. 
Published: May 2020

AbstractCoronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in‐person visits that may now be unsafe or impossible. Evidence‐ and experience‐based treatment options, such as multidisciplinary team care, feeding tubes, wheelchairs, home health, and hospice, have become more difficult to obtain and in some places are unavailable. In addition, the pandemic has impacted ALS clinical trials by impairing the ability to obtain measurements for trial eligibility, to monitor safety and efficacy outcomes, and to dispense study drug, as these also often rely on in‐person visits. We review opportunities for overcoming some of these challenges through telemedicine and novel measurements. These can reoptimize ALS care and research in the current setting and during future events that may limit travel and face‐to‐face interactions.
Weight-Dependent Intraspecific Variation in Reproductive Parameters of Female Golden Topminnows
Authors: Fetterman Jacob A , Green Christopher C 
Published: May 2020

Abstract
A culture demand has developed within the ornamental and baitfish industries for fishes of the genus Fundulus. Refining reproductive methods may not only benefit important industries, but related species of conservation concern as well. Golden Topminnows Fundulus chrysotus are a common fish species across their native range and they have their own ornamental demand. Low fecundity observed in species of Fundulus has been the main obstacle to their efficient culture. Therefore, the objective of this study was to determine the optimal female broodfish size for increasing certain reproductive parameters (fecundity, embryo, and larval morphometrics), which ultimately contributes to better survival from embryo to larva. Outdoor and indoor studies were conducted between April 2018 and July 2018. Three distinct female size-classes were stocked in an indoor recirculating aquaculture system and outdoor mesocosms. The indoor study involved palpating females once every 3–4 d for 2.5 weeks, and the outdoor study utilized mesocosms to assess natural embryo and larval metrics over a 10-week period. In indoor laboratory experiments, large females ovulated the greatest numbers of eggs; however, the number of eggs per gram (female weight; mean ± standard error of the mean) was proportional across all three size-classes (small: 2.8 ± 0.64; medium: 2.3 ± 0.51; large: 3.1 ± 0.51). In outdoor mesocosm experiments, larval TL and percentage of embryos surviving to hatch were lowest for large size-class progeny, which may have resulted from their relatively larger chorion size and nonstandardized incubation density contributing to inhibited development. Female Golden Topminnows proportionally invest in yolk production, and thus produce greater numbers of eggs.
Intraurethral catheter placement does not change the external circumferential measurement of the urethra during AUS placement: A prospective observational trial
Authors: Boysen William R. , Inouye Brian M. , Kowalik Urszula , Madden‐Fuentes Ramiro J. , Kahokehr Arman Adam , Peterson Andrew C. 
Published: May 2020

AbstractAimsMeasuring the urethral circumference accurately during artificial urethral sphincter (AUS) placement is an important technical aspect to optimize the selection of cuff size. Differing methods exist for this step with some experts recommending measurement with no urethral catheter in place. In this prospective observational trial, we compared urethral measurements with and without an indwelling catheter to determine if the presence of a catheter affects the circumferential measurement.MethodsWith IRB approval, we prospectively collected data on consecutive cases of transperineal male AUS implantation. Urethral circumference was measured with no urethral catheter (0 French [Fr]), 12Fr, and 16Fr Foley catheters in the urethra. The final measurements and cuff size chosen were recorded. A comparison was made between each measurement using Spearman's correlation coefficient.ResultsA total of 54 patients were included, the majority of whom (92.6%) underwent AUS placement for postprostatectomy incontinence. The three urethral circumference measurements were highly correlated (0Fr vs 12Fr, ρ = 0.96, P < .001, mean difference 1 mm) (0Fr vs 16Fr, ρ = 0.94, P < .001, mean difference 2 mm) (12Fr vs 16Fr, ρ = 0.96, P < .001, mean difference 1 mm). Patients with a history of radiation had a lower mean urethral circumference than those who had never been radiated (4.78 cm vs 5.3 cm, P = .01).ConclusionsUrethral circumference measurement during AUS implantation is not influenced by the presence of a 12 or 16Fr Foley catheter when compared to no catheter in the urethra. Measurement of the urethral circumference can, therefore, be accurately performed with or without a catheter in place, depending on the surgeon's preference.
Does the energy transfer from Ar(1s) atoms to N2 lead to dissociation?
Authors: Klages Claus‐Peter , Martinovs Andris , Bröcker Lars , Loffhagen Detlef 
Published: May 2020

AbstractDielectric‐barrier discharges (DBDs) in Ar–N2 mixtures, with N2 fractions in 0.1–1% range, would be attractive alternatives to DBDs in pure N2 if energy‐transfer reactions between Ar(1s) atoms and N2 molecules were an efficient source of N atoms. Attempts to functionalize polyolefins in flowing postdischarges fed by such DBDs, as well as the search for the First Positive System in the emission spectrum, however, failed. Evidently, the energy‐transfer reactions do not produce N atoms. For Ar(1s3) and Ar(1s5) metastable states, this fact has already been reported in the literature. For Ar(1s2) and Ar(1s4) resonant states, a quantitative argument is derived in this paper: energy transfer from Ar(1s) atoms to N2 molecules is not an efficient source of N atoms.
Comprehensive cardiopulmonary assessment in α mannosidosis
Authors: Nir Vered , Bentur Lea , Tal Galit , Gur Michal , Gut Guy , Ilivitzki Anat , Zucker‐Toledano Merav , Hanna Moneera , Toukan Yazeed , Bar‐Yoseph Ronen 
Published: May 2020

AbstractIntroductionα Mannosidosis is an extremely rare, progressive, and complex lysosomal storage disease, characterized by mental retardation, hearing impairment, coarse facial features, skeletal abnormalities, and pulmonary involvement. While bone marrow transplantation has been the only therapeutic option to date, nowadays new treatment options are being explored, which may affect pulmonary and exercise capacity.Aim and MethodsTo assess cardiopulmonary involvement in patients with α mannosidosis by pulmonary function tests, cardiopulmonary exercise testing, and low irradiation chest computed tomography (CT).ResultsFive patients aged 11 to 28 years were followed in our Respiratory‐Metabolic Clinic. All five had pulmonary symptoms and received inhaled therapy. Three patients underwent bone marrow transplantation. Parenchymal lung disease was evident in 3/5 chest CT tests. Pulmonary function tests were abnormal in all patients and showed obstructive/restrictive impairment with air trapping. All five patients showed reduced peak oxygen uptake (median 23.1; range 20.4‐32.2 mL/minute/kg, median %predicted 62; range %predicted 59‐79).ConclusionsPulmonary involvement is a known complication in this rare disease. Comprehensive cardiopulmonary evaluation is feasible among these patients and may help in assessing disease progression and response to new treatment modalities.
Parametric Type‐II Dirac Photonic Lattices
Authors: Jin Kaichao , Zhong Hua , Li Yongdong , Ye Fangwei , Zhang Yanpeng , Li Fuli , Liu Chunliang , Zhang Yiqi 
Published: May 2020

AbstractDifferent from the Fermi surface of the type‐I Dirac semimetal being a point, that of the type‐II Dirac semimetal is a pair of crossing lines because the Dirac cone is tilted with open and hyperbolic isofrequency contours. As an optical analogy, type‐II Dirac photonic lattices have been also designed. Here, type‐II Dirac cones are reported in Lieb‐like photonic lattices composed of identical waveguide channels, and the anisotropy of the band structure is due to neither the refractive index change nor the environment, but only the spatial symmetry of the lattice; therefore, the proposal is advantageous and benefits experimental observation. Conical diffractions and Klein tunneling in the parametric type‐II photonic lattice are investigated in detail. The results provide a simple and experimentally feasible platform to study two‐dimensional topological photonic and other nonrelativistic phenomena around type‐II Dirac cones.
A geospatial technique‐based site suitability analysis for construction of water reservoirs in Arsha and Balarampur Blocks, Purulia
Authors: Kar Surajit , Sen Ena , Mukherjee Subham 
Published: May 2020

AbstractWater security is a term associated with the availability of fresh water for all. However, this finite resource has certain other related factors, as water resource can act as a driver for development or underdevelopment. From ancient history to now, human civilization has been dependent on water resources, not only for drinking but for the maintenance of natural systems, for hunting and foraging, through to the growth of agriculture and industrialization. Moreover, the relationship between water resource and regional development becomes more prominent in those areas where this finite resource is scarce. In most dryland areas, water resource management becomes an integral part of regional policy for overall development. This study aims to understand the intensity of water resource scarcity and management through proper site selection in the southwestern part of West Bengal, particularly in Purulia district. The district is underdeveloped, as well as water stressed due to climatic, geological, and socioeconomic factors. Water scarcity in the district impacts agricultural productivity through wasteland generation, which also drives regional poverty and migration. This study also seeks to explain how sustainable development goals, such as climate change (SDGs 13), life on land (SDGs 15), and poverty (SDGs 1), are related to water security. With the help of a semi‐structured questionnaire, secondary data (census, 2011), and geographical information systems, we endorse the view that assessment and management of water through proper site selection can help drive integrated rural water security.
Predominant yeasts in the sourdoughs collected from some parts of Turkey
Authors: Boyaci‐Gunduz Cennet Pelin , Erten Huseyin 
Published: May 2020

AbstractIn the present study, a total of eight sourdough samples were collected from three different bakeries at two different times in Turkey. Also, laboratory‐scale sourdough production was conducted by daily back‐slopping for 7 days. Microbiological and chemical properties of the sourdoughs were investigated. Yeast species in the sourdoughs were identified by subjecting all presumptive yeast cultures to internal transcribed spacer region amplification of the 5.8S rRNA gene, restriction fragment length polymorphism analysis using Hae III, Hha I, and Hinf I endonucleases, and sequence analysis of the D1/D2 domain of the 26S rDNA gene. A total of seven profiles were determined according to the restriction fragments. Totally, 148 yeast isolates were identified at the species level (≥400 bp, 99% identity) as Saccharomyces cerevisiae (106), Kazachstania bulderi (11), Pichia fermentans (nine), Pichia membranifaciens (eight), Kazachstania servazzii (seven), Kazachstania unispora (four), and Hanseniaspora valbyensis (three). Although collected sourdoughs were produced without using baker's yeast, S. cerevisiae was the most frequently isolated yeast species. This can be related to the contamination of the bakery environment with commercial baker's yeast during the production of other bakery products. The pH and acidity levels of the collected sourdough samples ranged from 3.71 to 3.96 and 6.78 to 23.93 mL 0.1 N NaOH/10 g dough, respectively. Mean values of the content of maltose + sucrose, glucose, fructose, lactic acid, and acetic acid were 2.43, 1.57, 2.67, 7.30, and 1.40 g/kg, respectively. Due to the artisan and region‐dependent handling of the sourdough, different biochemical patterns were observed among the collected samples.
TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development
Authors: Yi Mei , Tan Yixin , Wang Li , Cai Jing , Li Xiaoling , Zeng Zhaoyang , Xiong Wei , Li Guiyuan , Li Xiayu , Tan Pingqing , Xiang Bo 
Published: May 2020

AbstractSquamous cell carcinoma (SCC) is an aggressive malignancy that can originate from various organs. TP63 is a master regulator that plays an essential role in epidermal differentiation. It is also a lineage-dependent oncogene in SCC. ΔNp63α is the prominent isoform of TP63 expressed in epidermal cells and SCC, and overexpression promotes SCC development through a variety of mechanisms. Recently, ΔNp63α was highlighted to act as an epidermal-specific pioneer factor that binds closed chromatin and enhances chromatin accessibility at epidermal enhancers. ΔNp63α coordinates chromatin-remodeling enzymes to orchestrate the tissue-specific enhancer landscape and three-dimensional high-order architecture of chromatin. Moreover, ΔNp63α establishes squamous-like enhancer landscapes to drive oncogenic target expression during SCC development. Importantly, ΔNp63α acts as an upstream regulator of super enhancers to activate a number of oncogenic transcripts linked to poor prognosis in SCC. Mechanistically, ΔNp63α activates genes transcription through physically interacting with a number of epigenetic modulators to establish enhancers and enhance chromatin accessibility. In contrast, ΔNp63α also represses gene transcription via interacting with repressive epigenetic regulators. ΔNp63α expression is regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational levels. In this review, we summarize recent advances of p63 in epigenomic and transcriptional control, as well as the mechanistic regulation of p63.
Epidemiology and treatment of phalangeal fractures: conservative treatment is the predominant therapeutic concept
Authors: Kremer Laura , Frank Johannes , Lustenberger Thomas , Marzi Ingo , Sander Anna Lena 
Published: May 2020

Abstract
Purpose
Despite the high number of patients with phalangeal fractures, evidence-based recommendations for the treatment of specific phalangeal fractures could not be concluded from the literature. The purpose of the present study was to assess current epidemiological data, classification of the fracture type, and mode of treatment.

Methods
This study presents a retrospective review of 261 patients with 283 phalangeal fractures ≥ 18 years of age who were treated in our level I trauma centre between 2017 and 2018. The data were obtained by the analysis of the institution’s database, and radiological examinations.

Results
The average age of the patients was 40.4 years (range 18–98). The ratio of male to female patients was 2.7:1. The two most typical injury mechanisms were crush injuries (33%) and falls (23%). Most phalangeal fractures occurred in the distal phalanx (P3 43%). The 4th ray (D4 29%) was most frequently affected. The P3 tuft fractures, and the middle phalanx (P2) base fractures each accounted for 25% of fracture types. A total of 74% of fractures were treated conservatively, and 26% required surgery, with Kirschner wire(s) (37%) as the preferred surgical treatment. The decision for surgical treatment correlated with the degree of angular and/or rotational deformity, intraarticular step, and sub-/luxation of specific phalangeal fractures, but not with age and gender.

Conclusions
Our findings demonstrated the popularity of conservative treatment of phalangeal fractures, while surgery was only required in properly selected cases. The correct definition of precise fracture pattern in addition to topography is essential to facilitate treatment decision-making.
Digital Public Health – Hebel für Capacity Building in der kommunalen Gesundheitsförderung
Authors: Zens Maria , Shajanian Zarneh Yvette , Dolle Jürgen , De Bock Freia 
Published: May 2020

ZusammenfassungMit der Ottawa-Charta von 1986 wurde ein Paradigmenwechsel vollzogen, der alle Public-Health-Anstrengungen auf die Stärkung kommunaler Aktivitäten und die Schaffung gesundheitsförderlicher Lebensumstände orientiert. Ein Schlüssel hierfür ist „capacity building“ (CB), verstanden als die Entwicklung und möglichst nachhaltige Implementierung von strukturellen Kapazitäten – wie koordinierte Datenerhebung, Abstimmungsprozesse über Sektorengrenzen hinweg, dauerhafte Bereitstellung grundständiger Ressourcen – in allen Bereichen der Gesundheitsförderung „vor Ort“.Vielfältige Anstrengungen und dreieinhalb Jahrzehnte später sehen wir uns noch viel zu oft Infrastrukturdefiziten, fragmentierten Public-Health-Landschaften und Hemmnissen für die intersektorale Zusammenarbeit gegenüber. Während der theoretische Konsens über das Notwendige breit erscheint, bleibt es eine Herausforderung, diese theoretischen Einsichten in die Praxis umzusetzen. In dieser Situation kann Digital Public Health (DPH) dazu beitragen, Barrieren zu überwinden und „Daten für Taten“ sichtbarer und zugänglicher zu machen. Durch DPH können Daten auf neuartige Weise integriert, strukturiert und disseminiert werden.In diesem Beitrag wird erörtert, wie die Kapazitätsentwicklung auf lokaler und kommunaler Ebene von technologischen Entwicklungen profitieren und was DPH für die Bereitstellung von Informationsservices im Bereich Public Health Capacity tun kann. Der Fokus liegt auf der webbasierten, interaktiven Repräsentation von Gesundheitsförderungsdaten, die für Informations‑, Steuerungs- und Benchmarkingzwecke genutzt werden können. Als Beispiel aus der Public-Health-Praxis wird das Tool „TEAviisari“ (National Institute for Health and Welfare, Finnland) vorgestellt.Die EU-Ratspräsidentschaft Deutschlands 2020 – u. a. mit den Themen Digitalisierung und gemeinsamer Gesundheitsdatenraum – bietet die Gelegenheit, die Kapazitätsentwicklung in der kommunalen Gesundheitsförderung auch hierzulande entscheidend voranzubringen.