bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics prognostication model in glioblastoma using diffusion- and perfusion-weighted MRI
Authors: Park Ji Eun , Kim Ho Sung , Jo Youngheun , Yoo Roh-Eul , Choi Seung Hong , Nam Soo Jung , Kim Jeong Hoon 
Published: March 2020

AbstractWe aimed to develop and validate a multiparametric MR radiomics model using conventional, diffusion-, and perfusion-weighted MR imaging for better prognostication in patients with newly diagnosed glioblastoma. A total of 216 patients with newly diagnosed glioblastoma were enrolled from two tertiary medical centers and divided into training (n = 158) and external validation sets (n = 58). Radiomic features were extracted from contrast-enhanced T1-weighted imaging, fluid-attenuated inversion recovery, diffusion-weighted imaging, and dynamic susceptibility contrast imaging. After radiomic feature selection using LASSO regression, an individualized radiomic score was calculated. A multiparametric MR prognostic model was built using the radiomic score and clinical predictors. The results showed that the multiparametric MR prognostic model (radiomics score + clinical predictors) exhibited good discrimination (C-index, 0.74) and performed better than a conventional MR radiomics model (C-index, 0.65, P < 0.0001) or clinical predictors (C-index, 0.66; P < 0.0001). The multiparametric MR prognostic model also showed robustness in external validation (C-index, 0.70). Our results indicate that the incorporation of diffusion- and perfusion-weighted MR imaging into an MR radiomics model to improve prognostication in glioblastoma patients improved its performance over that achievable using clinical predictors alone.
Digestibility, textural and sensory characteristics of cookies made from residues of enzyme-assisted aqueous extraction of soybeans
Authors: Li Yang , Sun Yufan , Zhong Mingming , Xie Fengying , Wang Huan , Li Liang , Qi Baokun , Zhang Shuang 
Published: March 2020

AbstractEnzyme-assisted aqueous extraction residue (REAE) has a lower utilization rate as it is the “waste” produced after the enzyme-assisted aqueous extraction (EAE), but its nutritional value is high. To improve the development and utilization of REAE, in this study, cookies were made by adding REAE (0%, 10%, 20%, 30%, 40%, 50%) as a food additive to a small amount of flour. The AOAC method was used to identify the basic components of REAE, analyze its physical and chemical properties, and characterize the cookie structure change in terms of texture, disulfide bond, and thiol content. An in vitro simulation system and sensory evaluation mechanism were established to analyze the bioavailability and impact of quality. The results show that REAE is a potential food additive. With an increase in the REAE content, the cookies become lighter in color, the sweetness and fat content are reduced, the hardness is increased, and the digestibility and glycerin index are reduced. The change in texture is caused by the reduction of disulfide bonds in the dough. The cookies were ‘well accepted’ with up to 30% REAE. Therefore, the use of the appropriate amount of REAE as a new food additive will reduce the amount of starch added.
Giant defect emission enhancement from ZnO nanowires through desulfurization process
Authors: Zhou Junze , Nomenyo Komla , Cesar Clotaire Chevalier , Lusson Alain , Schwartzberg Adam , Yen Chun-Chieh , Woon Wei-Yen , Lerondel Gilles 
Published: March 2020

AbstractZinc oxide (ZnO) is a stable, direct bandgap semiconductor emitting in the UV with a multitude of technical applications. It is well known that ZnO emission can be shifted into the green for visible light applications through the introduction of defects. However, generating consistent and efficient green emission through this process is challenging, particularly given that the chemical or atomic origin of the green emission in ZnO is still under debate. In this work we present a new method, for which we coin term desulfurization, for creating green emitting ZnO with significantly enhanced quantum efficiency. Solution grown ZnO nanowires are partially converted to ZnS, then desulfurized back to ZnO, resulting in a highly controlled concentration of oxygen defects as determined by X-ray photoelectron spectroscopy and electron paramagnetic resonance. Using this controlled placement of oxygen vacancies we observe a greater than 40-fold enhancement of integrated emission intensity and explore the nature of this enhancement through low temperature photoluminescence experiments.
Experimental quantification of pollen with DNA metabarcoding using ITS1 and trnL
Authors: Baksay Sandra , Pornon André , Burrus Monique , Mariette Jérôme , Andalo Christophe , Escaravage Nathalie 
Published: March 2020

AbstractAlthough the use of metabarcoding to identify taxa in DNA mixtures is widely approved, its reliability in quantifying taxon abundance is still the subject of debate. In this study we investigated the relationships between the amount of pollen grains in mock solutions and the abundance of high-throughput sequence reads and how the relationship was affected by the pollen counting methodology, the number of PCR cycles, the type of markers and plant species whose pollen grains have different characteristics. We found a significant positive relationship between the number of DNA sequences and the number of pollen grains in the mock solutions. However, better relationships were obtained with light microscopy as a pollen grain counting method compared with flow cytometry, with the chloroplastic trnL marker compared with ribosomal ITS1 and with 30 when compared with 25 or 35 PCR cycles. We provide a list of recommendations to improve pollen quantification.
Efficacy of local infiltration analgesia with ropivacaine for postoperative pain management in cervical laminoplasty: a retrospective study
Authors: Li Kunpeng , Li Hao , Luo Dawei , Feng Hongyong , Ji Changbin , Yang Keshi , Liu Jinlong , Zhang Honglei , Xu Hui 
Published: March 2020

AbstractPoor postoperative pain control impairs patient recovery and lengthens the duration of hospitalization after various surgeries. Local infiltration analgesia(LIA) has become an effective method for managing postoperative pain. This study aimed to investigate the efficacy of LIA with ropivacaine for postoperative pain control after cervical laminoplasty. In total, 68 patients undergoing cervical laminoplasty were included for retrospective review and divided into ropivacaine and control groups. The visual analogue scale (VAS) score, postoperative analgesic consumption, operative duration, intraoperative blood loss volume, incision length, hospitalization duration and incidence of complications were analyzed. In the ropivacaine group, the VAS score was 3.2 ± 1.4 at 4 hours postoperatively, which was lower than that of the control group(4.0 ± 1.4, P = 0.024). At 8, 12 and 24 hours after surgery, a significant difference was detected in the VAS score between the two groups(P ≤ 0.015). Sufentanil consumption was less in the ropivacaine group than in the control group in the first 4 hours postoperatively (25.6 ± 6.3 µg vs 32.2 ± 6.8 µg, P < 0.001), and similar results were observed in the first 8, 12, 24, 48 and 72 hours postoperatively(P < 0.001). Fewer patients required rescue analgesia in the ropivacaine group(8/33 vs 18/35 at 4–8 hours, P = 0.021; 9/33 vs 21/35 at 8–12 hours, P = 0.007). The hospitalization duration and time to ambulation were shorter in the ropivacaine group(8.5 ± 1.4 vs 9.6 ± 1.6 for postoperative duration, P = 0.002; 2.9 ± 0.7 vs 3.5 ± 0.8 for time to ambulation, P = 0.001). The incidence of nausea and vomiting was lower in the ropivacaine group than in the control group(30.3% vs 54.3%, P = 0.046). In conclusion, LIA with ropivacaine could effectively reduce postoperative pain, and postoperative analgesic consumption, and promote recovery after cervical laminoplasty.
Air pollution by NO2 is associated with the risk of Bell’s palsy: A nested case-controlled study
Authors: Kim So Young , Min Chanyang , Choi Jay , Park Bumjung , Choi Hyo Geun 
Published: March 2020

AbstractThis study investigated the relationship of weather and air pollution with the onset of Bell’s palsy. The Korean Health Insurance Review and Assessment Service-National Sample Cohort (HIRA-NSC) data from 2002 through 2013 were used. The 3,935 Bell’s palsy patients were matched with 15,740 control participants. The meteorological data, including daily mean temperature (°C), daily mean highest temperature (°C), daily mean lowest temperature (°C), daily mean temperature difference (°C), relative humidity (%), spot atmospheric pressure (hPa), sulfur dioxide (SO2) (ppm), nitrogen dioxide (NO2) (ppm), ozone (O3) (ppm), carbon monoxide (CO) (ppm), and PM10(particulate matter ≤ 10 μg/m3) for 60 days, 30 days, 14 days, 7 days, and 3 days prior to the index date were analyzed for Bell’s palsy cases and controls. Conditional logistic regression analysis was used to estimate the odds ratios (ORs) of the association between the meteorological data and Bell’s palsy. The mean NO2and PM10concentrations for 60 days were higher, while that of O3was lower in the Bell’s palsy group than in the control group (both P < 0.001). The Bell’s palsy group showed 16.63-fold higher odds of NO2for 60 days (0.1 ppm) than the control group (95% CI = 10.18–27.16, P < 0.001). The ORs of PM10, and O3for 60 days showed inconsistent results according to the included variables. Bell’s palsy was related to high concentrations of NO2.
Angiotensin-[1–7] attenuates kidney injury in experimental Alport syndrome
Authors: Choi Hong Sang , Kim In Jin , Kim Chang Seong , Ma Seong Kwon , Scholey James W. , Kim Soo Wan , Bae Eun Hui 
Published: March 2020

AbstractAngiotensin-[1–7] (Ang-[1–7]) antagonize the actions of the renin-angiotensin-system via the Mas receptor and thereby exert renoprotective effects. Murine recombinant angiotensin-converting enzyme (ACE)2 was reported to show renoprotective effects in an experimental Alport syndrome model; however, the protective effect of direct administration of Ang-[1–7] is unknown. Here, we used Col4a3−/− mice as a model of Alport syndrome, which were treated with saline or Ang- [1–7]; saline-treated wild-type mice were used as a control group. The mice were continuously infused with saline or Ang-[1–7] (25 μg/kg/h) using osmotic mini-pumps. Col4a3−/− mice showed increased α-smooth muscle actin (SMA), collagen, and fibronectin expression levels, which were attenuated by Ang-[1–7] treatment. Moreover, Ang-[1–7] alleviated activation of transforming growth factor-β/Smad signaling, and attenuated the protein expression of ED-1 and heme oxygenase-1, indicating reduction of renal inflammation. Ang-[1–7] treatment further reduced the expression levels of inflammatory cytokines and adhesion molecules and attenuated apoptosis in human kidney cells. Finally, Ang-[1–7] downregulated TNF-α converting enzyme and upregulated ACE2 expression. Thus, treatment with Ang-[1–7] altered the ACE2-Ang-[1–7]-Mas receptor axis in the kidneys of Col4a3−/− mice to attenuate the nephropathy progression of Alport syndrome.
Uncovering diversity and metabolic spectrum of animals in dead zone sediments
Authors: Broman Elias , Bonaglia Stefano , Holovachov Oleksandr , Marzocchi Ugo , Hall Per O. J. , Nascimento Francisco J. A. 
Published: March 2020

AbstractOcean deoxygenation driven by global warming and eutrophication is a primary concern for marine life. Resistant animals may be present in dead zone sediments, however there is lack of information on their diversity and metabolism. Here we combined geochemistry, microscopy, and RNA-seq for estimating taxonomy and functionality of micrometazoans along an oxygen gradient in the largest dead zone in the world. Nematodes are metabolically active at oxygen concentrations below 1.8 µmol L−1, and their diversity and community structure are different between low oxygen areas. This is likely due to toxic hydrogen sulfide and its potential to be oxidized by oxygen or nitrate. Zooplankton resting stages dominate the metazoan community, and these populations possibly use cytochrome c oxidase as an oxygen sensor to exit dormancy. Our study sheds light on mechanisms of animal adaptation to extreme environments. These biological resources can be essential for recolonization of dead zones when oxygen conditions improve.
NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells
Authors: Watari Kosuke , Shibata Tomohiro , Fujita Hideaki , Shinoda Ai , Murakami Yuichi , Abe Hideyuki , Kawahara Akihiko , Ito Hiroshi , Akiba Jun , Yoshida Shigeo , Kuwano Michihiko , Ono Mayumi 
Published: March 2020

AbstractMany diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc downstream regulated gene 1 (NDRG1) to VEGF-A-induced angiogenesis in vascular endothelial cells (ECs). Ndrg1−/− mice exhibit impaired VEGF-A-induced angiogenesis in corneas. Tumor angiogenesis induced by cancer cells that express high levels of VEGF-A was also reduced in a mouse dorsal air sac assay. Furthermore, NDRG1 deficiency in ECs prevented angiogenic sprouting from the aorta and the activation of phospholipase Cγ1 (PLCγ1) and ERK1/2 by VEGF-A without affecting the expression and function of VEGFR2. Finally, we show that NDRG1 formed a complex with PLCγ1 through its phosphorylation sites, and the inhibition of PLCγ1 dramatically suppressed VEGF-A-induced angiogenesis in the mouse cornea, suggesting an essential role of NDRG1 in VEGF-A-induced angiogenesis through PLCγ1 signaling.
Ultrashort low-loss Ψ gates for linear optical logic on Si photonics platform
Authors: Kita Shota , Nozaki Kengo , Takata Kenta , Shinya Akihiko , Notomi Masaya 
Published: March 2020

AbstractNonlinear optical gates are usually considered as fundamental building blocks for universal optical computation. However, the performance is severely limited by small optical nonlinearity, thereby bounding their operation speed, consumption energy, and device size. In this paper, we propose and experimentally demonstrate linear optical logic operations with ~3 μm-long Si wire “Ψ” gates consist of 3 × 1 optical combiners including auxiliary bias port, which maximizes the binary contrast of the output in telecom wavelength. We have demonstrated 20 Gbps Boolean “AND” operation with experimentally measured small signal loss (1.6 dB experimentally). A single Ψ gate can perform representative Boolean operations by changing the bias power and relative phases. We have also demonstrated wavelength-independent operation by seven wavelengths, which leads to wavelength-division multiplexed parallel computation. This ultrashort, highly-integrable, low-loss, and energy-efficient optical logic gates pave the way for ultralow latency optical pattern matching, recognition, and conversion.
Association between MGMT status and response to alkylating agents in patients with neuroendocrine neoplasms: a systematic review and meta-analysis
Authors: Qi Zhirong , Tan Huangying 
Published: March 2020

Abstract
Background: O6-methylguanine-DNA methyltransferase (MGMT) is a specific DNA damage reversal repair protein. The influence of MGMT status on alkylating agent sensitivity in patients with neuroendocrine neoplasms (NENs) is controversial. We conducted a meta-analysis to assess the influence of MGMT status on the therapeutic sensitivity of alkylating agents in patients with NENs.
Methods: We searched PubMed, EmBase, and Cochrane library public databases through 3 July 2019. The objective response rate (ORR) was the outcome data of interest. Subgroup analysis was performed according based on MGMT methylation and expression of MGMT protein.
Results: Eleven studies were included in the meta-analysis. The proportion of patients with NENs that achieved an ORR after alkylating agent treatment was higher in the MGMT-deficient group than the non-deficient group (OR: 5.00; 95% CI: 3.04–8.22; P &lt; 0.001; I2: 3%). Similar results were noted in the MGMT methylation and MGMT protein expression subgroups.
Conclusion: Patients with NENs and MGMT methylation or low protein expression had a higher ORR proportion than patients without MGMT methylation or high protein expression. The MGMT status can be used as a biological indicator of the response to alkylating agent treatment in patients with NENs.
Photospheric magnetic topology of a north polar region
Authors: Pastor Yabar A. , Martínez González M. J. , Collados M. 
Published: March 2020

Aims. We aim to characterise the magnetism of a large fraction of the north polar region close to a maximum of activity, when the polar regions are reversing their dominant polarity.
Methods. We make use of full spectropolarimetric data from the CRisp Imaging Spectro-Polarimeter installed at the Swedish Solar Telescope. The data consist of a photospheric spectral line, which is used to infer the various physical parameters of different quiet Sun regions by means of the solution of the radiative transfer equation. We focus our analysis on the properties found for the north polar region and their comparison to the same analysis applied to data taken at disc centre and low-latitude quiet Sun regions for reference. We also analyse the spatial distribution of magnetic structures throughout the north polar region.
Results. We find that the physical properties of the polar region (line-of-sight velocity, magnetic flux, magnetic inclination and magnetic azimuth) are compatible with those found for the quiet Sun at disc centre and are similar to the ones found at low latitudes close to the limb. Specifically, the polar region magnetism presents no specific features. The structures for which the transformation from a line-of-sight to a local reference frame was possible harbour large magnetic fluxes (>1017 Mx) and are in polarity imbalance with a dominant positive polarity, the largest ones (>1019 Mx) being located below 73° latitude.
Kinderwunsch bei Multipler Sklerose
Authors: Hellwig Kerstin , Wilkening Wibke 
Published: March 2020

ZUSAMMENFASSUNGEine Multiple Sklerose (MS) tritt meist im reproduktionsfähigen Alter auf. Deshalb ist die Frage der Familienplanung bei Patienten mit MS von großer Bedeutung. Die Datenlage zu den krankheitsmodifizierenden Therapien (DMT) im Hinblick auf Familienplanung, Schwangerschaft und Stillzeit wächst, auch wenn viele Fragen nicht eindeutig beantwortet werden können.
Therapie der hochaktiven Multiplen Sklerose
Authors: Pul Refik , Kleinschnitz Christoph 
Published: March 2020

ZUSAMMENFASSUNGImmuntherapien bei Multipler Sklerose müssen sich nach randomisiert kontrollierten klinischen Studien auch in der klinischen Routine bewähren. Dazu werden Register- und Kohortenstudien durchgeführt. Eine große Kohortenstudie an den Universitätskliniken Essen-Duisburg und Münster untersucht Wirksamkeit und Sicherheit von Cladribin-Tabletten im klinischen Alltag. Erste Analysen scheinen die Ergebnisse der Zulassungsstudie CLARITY in einer breiter gefassten Patientenpopulation zu bestätigen.
Partial Capitate with/without Hamate Osteotomy in the Treatment of Kienböck's Disease: Influence of the Stage of the Disease on the Midterm Outcome
Authors: Atiyya Ahmed Naeem , Nabil Amr , El Lattif Aly Ibrahim Abd , El Saied Mohamed Nabil , Soliman Ramy Ahmed 
Published: March 2020

Abstract
Objective Moritomo et al introduced partial capitate osteotomy as a treatment modality for early stages of Kienböck's disease. This technique maintains articular contact between the capitate and the scaphoid. We added hamate-shortening osteotomy in addition to partial capitate shortening in cases of lunate type II. The purpose of this study was to evaluate intermediate-term results of partial capitate shortening, investigate the influence of the stage of the disease on the outcome, and assess the clinical and radiological outcomes of adding hamate osteotomy in cases of type II lunate.
Patients and Methods A total of 17 consecutive patients (3 women, 14 men) with early stages of Kienböck's disease were prospectively reviewed using the aforementioned technique. Eight patients were in stage II and nine patients were in stage IIIA according to the Lichtman classification system. Clinical outcome measures included pain visual analog score, grip strength and range of motion as a percentage of the unaffected side, and assessment using the Patient-Rated Hand and Wrist Evaluation (PRHWE) and the modified Wrightington Hospital Wrist Score (MWHWS). Radiological outcome measures included healing of the osteotomy site, Stahl index, radioscaphoid angle, and progression of the disease.
Results Follow-up period averaged 72 months. All cases of isolated capitate osteotomy and combined capitate and hamate osteotomies united fully. Clinical results revealed significant improvement in pain, grip strength and extension, and PRHWE and MWHWS values. Wrist flexion did not change postoperatively. Patients with stage II showed better overall results and significant MWHWS improvement.
Conclusion At the intermediate term, partial capitate with/without hamate shortening is an effective modality for the treatment of patients with early stage Kienböck's disease. Stage II patients showed better results than stage IIIA patients in terms of pain, flexion, grip, PRHWE, and MWHWS. Adding hamate osteotomy may improve the functional results for type II lunate; however, a larger sample is needed to elicit statistical significance.
Level of Evidence This is a Level IV, therapeutic study.
Infantile Spasms: Opportunities to Improve Care
Authors: Messer Ricka , Knupp Kelly G. 
Published: March 2020

AbstractInfantile spasm (IS) is a distinct epilepsy syndrome characterized by epileptic spasms (the clinical seizure type) and hypsarrhythmia (the electrographic abnormality). IS is frequently accompanied by impaired neurodevelopment and is often associated with structural, genetic, or metabolic etiologies. Prompt treatment of this severe epileptic encephalopathy improves long-term outcomes but remains elusive in many situations. Despite common misconceptions, even patients with identified etiologies or preexisting developmental delay benefit from proven standard therapies, including adrenocorticotropic hormone (ACTH), oral corticosteroids, or vigabatrin. Treatment efficacy should be assessed with electroencephalography at 2 weeks, and an alternative therapy is indicated if epileptic spasms or hypsarrhythmia have not resolved. Collaboration with primary care providers is critical to mitigate the potentially serious adverse effects of standard treatments and also to provide developmental interventions. Although new approaches are on the horizon, addressing current challenges and opportunities now can dramatically improve patient outcomes.
Sugammadex: Applications in Pediatric Critical Care
Authors: Tobias Joseph D. 
Published: March 2020

AbstractSugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade with a mechanism that differs from acetylcholinesterase inhibitors such as neostigmine. There is a growing body of literature demonstrating its efficacy in pediatric patients of all ages. Prospective trials have demonstrated a more rapid and more complete reversal of rocuronium-induced neuromuscular blockade than the acetylcholinesterase inhibitor, neostigmine. Unlike the acetylcholinesterase inhibitors, sugammadex effectively reverses intense or complete neuromuscular blockade. It may also be effective in situations where reversal of neuromuscular blockade is problematic including patients with neuromyopathic conditions or when acetylcholinesterase inhibitors are contraindicated. This article reviews the physiology of neuromuscular transmission as well as the published literature, regarding the use of sugammadex in pediatric population including the pediatric intensive care unit population. Clinical applications are reviewed, adverse effects are discussed, and dosing algorithms are presented.