bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation software tool (ValT) for predictive microbiology based on the acceptable prediction zones method
Authors: Oscar Thomas P. 
Published: January 2020

AbstractA study was undertaken to develop a user‐friendly software tool (ValT) for validation of predictive models based on the acceptable prediction zones (APZ) method. ValT was developed in Excel and was demonstrated using a newly developed growth model for Salmonella and chicken skin. The model provided acceptable predictions when the proportion (p) of residuals in the APZ was ≥0.70 and there were no local prediction problems. The pAPZ were 0.97 for dependent data (n = 360), 0.93 for interpolation data (n = 160) and 0.88 for extrapolation data (n = 180) to kosher chicken skin. There were no local prediction problems, and all sets of data satisfied the test data criteria of the APZ method. Thus, the model was successfully validated for interpolation and for extrapolation to kosher chicken skin. It is hoped that the new software tool will make it easier to validate models using the APZ method.
Antioxidant and apoptotic potential of protein isolates derived from Vigna unguiculata (L.) Walp
Authors: Thumbrain Dinelle , Dwarka Depika , Gerrano Abe S. , Mellem John J. 
Published: January 2020

SummaryProjected mortalities from cancer are expected to continue escalating, with conventional chemotherapeutic regimens having extensive side effects, hence the need for therapeutics capable of terminating cancer cells selectively, through apoptosis. Therapeutic protein isolates bind specifically to target proteins inducing cell death in vitro and in vivo in various cancer cells. Therefore, this study aimed at observing the antioxidant and anticancer potential of protein isolates from five cowpea cultivars (Glenda, Embu buff, Makhatini, Veg Cowpea 2 and Veg Cowpea 3). Cytotoxicity was conducted on cancerous and non‐cancerous cell lines. Apoptosis was quantified using flow cytometry, and caspase‐3/7 activity was determined. Cytotoxicity assays revealed that Embu buff was the pre‐eminent inhibitor of cancerous cells, while also acting as a protecting mediator in a stressed non‐cancerous cell line by causing a reversal in apoptotic activity. Therefore, cowpea isolates show high potential as candidates for the therapeutic intrusion of cancer.
Development and evaluation of a multimodality simulation disaster education and training program for hospital nurses
Authors: Noh Jiyoung , Oh Eui Geum , Kim So Sun , Jang Yeon Soo , Chung Hyun Soo , Lee Ogcheol 
Published: January 2020

AbstractAim: To develop a multimodality simulation program for hospital nurses to enhance their disaster competency and evaluate the effect of the program.Methods: The program implementation started in October 2016 and ended in December 2016. It was developed using the ADDIE model (analysis, design, development, implementation, and evaluation). Evaluation consisted of formative assessment and summative assessment. Formative assessment was performed during triage, crisis management, and problem‐solving simulation programs through direct feedback and debriefing from the teacher. Summative assessment was performed using the Kirkpatrick curriculum evaluation framework.Results: Needs assessment using the modified Delphi survey resulted in these competencies for hospital disaster nursing: triage, incident command, surge capacity, life‐saving procedures, and special situations. Each competency was matched with the appropriate simulation modalities. A total of 40 emergency nurses participated in the study program. The evaluation of the program resulted in improvement in perception, crisis management, problem solving, and technical skills in disaster nursing.Conclusion: Multimodality simulation training program was developed to enhance the competency of hospital nurses in disaster response. All participants improved their disaster response competencies significantly. The program that was developed in this study could be used as a fundamental tool in future research in disaster curriculum development.
Factors associated with quality of life among mothers of children with cerebral palsy
Authors: Farajzadeh Ata , Maroufizadeh Saman , Amini Malek 
Published: January 2020

AbstractAimTo identify the factors pertaining to the quality of life (QOL) among the mothers of patients with cerebral palsy.MethodsIn this cross‐sectional study, 203 mothers of children with cerebral palsy were selected using convenience sampling. The World Health Organization's Quality of Life Questionnaire (WHOQOL‐BREF), the Beck Depression Inventory, the Caregiver Difficulties Scale, Fatigue Severity Scale, and a demographic information questionnaire were administered to these caregivers. Hierarchical multiple linear regression analysis was used to detect the factors associated with QOL.ResultsModerate to high significant negative correlations were observed between all WHOQOL‐BREF domains and the other measures. The demographic/clinical variables were controlled, and hierarchical multiple linear regression analysis was run. The results indicated that depression, the burden of care, fatigue, and the type of cerebral palsy could significantly predict QOL in these mothers. Furthermore, QOL was lower in the mothers of children with tetraplegia than those of children with other types of disabilities (P < .05).ConclusionQOL of mothers of children with cerebral palsy is negatively impacted by various factors such as burden of care, fatigue, and psychological symptoms. Thus, a holistic approach, including training (carrying, positioning, feeding, and how to manage the self‐care of children) and psychological interventions, is required to improve QOL among this population.
Providing more or less detailed information in job advertisements—Does it matter?
Authors: Liu Yu‐Lun 
Published: January 2020

AbstractJob advertising is a common and useful recruitment marketing method that is available to a wide range of candidates and offers a practical way to widen the applicant pool. Frequently, retail advertisements only briefly introduce job requirements, but others provide more detailed information. Existing message studies, however, are inconclusive about the effectiveness of message specificity. A scenario‐based experiment that included 164 participants revealed that the type of decision maker (maximizer or satisficer) moderates the specificity effects in recruitment messages. After receiving a detailed job message, more satisficers stop their search process, but only maximizers perceive the company as more attractive and increase intentions toward the advertised job. A follow‐up qualitative study involving 30 participants provided further insights.
Robot‐assisted radical cystectomy: Review of surgical technique, and perioperative, oncological and functional outcomes
Authors: Elsayed Ahmed S , Aldhaam Naif A , Nitsche Lindsay , Siam Alat , Jing Zhe , Hussein Ahmed A , Shigemura Katsumi , Fujisawa Masato , Guru Khurshid A 
Published: January 2020

AbstractSince the introduction of robot‐assisted radical cystectomy, efforts have been made to meet the standards in terms of perioperative safety and oncological efficacy. Several randomized controlled studies and meta‐analyses, and multi‐institutional studies have shown comparable outcomes of robot‐assisted radical cystectomy when compared with the conventional open approach. In this review, we aimed to describe the surgical technique of robot‐assisted radical cystectomy and urinary diversion, and perioperative, pathological, oncological and functional outcomes.
The practicability and relevance of developing a yoga intervention for mental health consumers: A qualitative study
Authors: Snaith Nicole , Rasmussen Philippa , Schultz Tim , Proeve Michael 
Published: January 2020

AbstractThe aim of the study was to understand the perspectives of mental health consumers, staff, and yoga teachers on the characteristics of a yoga‐based intervention to be developed for consumers with a long‐term mental health condition, in addition to anxiety and/or depression. Two focus groups were held with mental health consumers (n = 8), two focus groups with mental health staff (n = 13) from a metropolitan community mental health setting, and five one‐on‐one interviews with yoga teachers. Participants were asked about the feasibility and appropriateness of a range of yoga practice features to be tested as a newly developed yoga‐based intervention. Thematic analysis was used to identify themes. Findings included the following consumer themes: Mental health understanding and experience of teachers and participants is important, Creating a safe space and Yoga practice elements. Staff themes included Mental health understanding and experience of teachers is important, Environmental design, and Yoga practice elements. Yoga teacher themes included Environmental design and Yoga practice elements. Mental health understanding and experience of the yoga teacher, and trauma‐informed care were consistently emphasized by consumers and staff. Teachers focused less on specific mental health considerations, which may be reflective of a broader knowledge gap. Recommendations regarding yoga practice elements, including pre‐information, regular and consistent practice, modifications, breathwork, mindfulness and guided practice, and environmental design features, were consistent with current trauma‐informed yoga research. Findings will be used to guide the development of a yoga‐based intervention for consumers with a long‐term mental health condition, in addition to anxiety and/or depression.
Strategies to optimize bonding of adhesive materials to molar‐incisor hypomineralization‐affected enamel: A systematic review
Authors: Lagarde Marianne , Vennat Elsa , Attal Jean‐Pierre , Dursun Elisabeth 
Published: January 2020

AbstractBackgroundChildren with first permanent molar affected by molar‐incisor hypomineralization (MIH) show high treatment failure rate.AimTo conduct a systematic review on bonding of adhesive materials to MIH‐affected enamel, so as to identify all the methods suggested to optimize it and to determine the best bonding protocol(s).DesignAn exhaustive literature search was conducted on MEDLINE/PubMed, the Cochrane Library, and Web of Science databases, up to October 2018. Laboratory and clinical studies, involving adhesive restorations bonded to MIH‐affected enamel, with at least a comparative group were included. Two authors independently selected studies, collected data, and assessed bias risk.ResultsAfter title and abstract review and duplicate exclusion, 14 articles were selected on the 496 eligible papers. After full reading, 4 articles were excluded. Finally, 10 studies (6 laboratory and 4 clinical studies) were included.ConclusionsBond strength of composite was not significantly different when using self‐etch compared with etch‐and‐rinse adhesives. Deproteinization after etching for etch‐and‐rinse adhesives enhanced bond strength; this could allow to keep MIH‐affected enamel. Icon® showed an erratic penetration; however, a preliminary deproteinization after etching could improve bond strength. A study reported no significant differences in sealant retention rate, whereas another recommended to previously apply an adhesive.
Searching for correlations between vibrational spectral features and structural parameters of silicate glass network
Authors: Liu Hongshen , Hahn Seung Ho , Ren Mengguo , Thiruvillamalai Mahadevan , Gross Timothy M. , Du Jincheng , van Duin Adri C. T. , Kim Seong H. 
Published: January 2020

AbstractInfrared (IR) and Raman spectroscopic features of silicate glasses are often interpreted based on the analogy with those of smaller molecules, molecular clusters, or crystalline counterparts; this study tests the accuracy and validity of these widely cited peak assignment schemes by comparing vibrational spectral features with bond parameters of the glass network created by molecular dynamics (MD) simulations. A series of sodium silicate glasses with compositions of [Na2O]x[Al2O3]2[SiO2]98−x with x = 7, 12, 17, and 22 were synthesized and analyzed with IR and Raman. A silica glass substrate and a crystalline quartz were also analyzed for comparison. Glass structures with the same compositions were generated with MD simulations using three types of potentials: fixed partial charge pairwise (Teter), partial diffuse charge potential (MGFF), and bond order‐based charge transfer potential (ReaxFF). The comparison of simulated and experimental IR spectra showed that, among these three potentials tested, ReaxFF reproduces the concentration dependence of spectral features closest to the experimentally observed trend. Thus, the bond length and angle distributions as well as Si–Qn species and ring size distributions of silica and sodium silicate glasses were obtained from ReaxFF‐MD simulations and further compared with the peak assignment or deconvolution schemes—which have been widely used since 1970s and 1980s—(a) correlation between the IR peak position in the Si–O stretch region (1050‐1120 cm−1) and the Si–O–Si bond angle; (b) deconvolution of the Raman bands in the Si–O stretch region with the Qn speciation; and (c) assignment of the Raman bands in the 420‐600 cm−1 region to the bending modes of (SiO)n rings with different sizes (typically, n = 3‐6). The comparisons showed that none of these widely used methods is congruent with the bond parameters or structures of silicate glass networks produced via ReaxFF‐MD simulations. This finding invokes that the adequacy of these spectral interpretation methods must be questioned. Alternative interpretations are proposed, which are to be tested independently in future studies.
Bioinspired alumina/reduced graphene oxide fibrous monolithic ceramic and its fracture responses
Authors: Chen Shuna , Su Yunfeng , Song Junjie , Fan Hengzhong , Jiang Xiaofang , Hu Litian , Zhang Yongsheng 
Published: January 2020

AbstractNatural composites have very simple compositions and complex hierarchical architectures consisting of several different levels. These features simultaneously endow them with strength, toughness, functional adaptation, and damage‐healing characteristics. Inspired by the microstructural features of natural materials, this work successfully fabricated Al2O3/reduced graphene oxide (rGO) fibrous monolithic ceramics with bamboo‐like structures by introducing a thin graphene oxide around Al2O3 fiber cells to form the rGO boundary phase. The detailed evolutions of the crack extension and fracture responses were investigated by a J‐integral method, and these bamboo‐like composites demonstrated high structural reliability with excellent damage tolerance and progressive plastic failure behavior. With the fiber cell diameter of 0.6 mm, such composites exhibited fracture toughness (29.46 ± 3.04 MPa m1/2) and work of fracture (799 ± 127 J m−2) that were 475% and 1075% higher than those of the monolithic Al2O3 ceramic, respectively. Their excellent fracture‐resistant behavior was attributed to the hierarchical architectures that provide crack deflection, delamination, and load redistribution. The results also established the structure‐activity relationships to guide the design and fabrication of these bamboo‐like composites.
PTBP3 promotes malignancy and hypoxia‐induced chemoresistance in pancreatic cancer cells by ATG12 up‐regulation
Authors: Ma Jun , Weng Li , Jia Yiping , Liu Bingyan , Wu Shaoqiu , Xue Lei , Yin Xiang , Mao Aiwu , Wang Zhongmin , Shang Mingyi 
Published: January 2020

AbstractPancreatic ductal adenocarcinoma (PDAC) tumours exhibit a high level of heterogeneity which is associated with hypoxia and strong resistance to chemotherapy. The RNA splicing protein polypyrimidine tract‐binding protein 3 (PTBP3) regulates hypoxic gene expression by selectively binding to hypoxia‐regulated transcripts. We have investigated the role of PTBP3 in tumour development and chemotherapeutic resistance in human PDAC tissues and pancreatic cancer cells. In addition, we determined the sensitivity of cancer cells to gemcitabine with differential levels of PTBP3 and whether autophagy and hypoxia affect gemcitabine resistance in vitro. PTBP3 expression was higher in human pancreatic cancer than in paired adjacent tissues. PTBP3 overexpression promoted PDAC proliferation in vitro and tumour growth in vivo, whereas PTBP3 depletion had opposing effects. Hypoxia significantly increased the expression of PTBP3 in pancreatic cancer cells in vitro. Under hypoxic conditions, cells were more resistance to gemcitabine. Knockdown of PTBP3 results in decreased resistance to gemcitabine, which was attributed to attenuated autophagy. We propose that PTBP3 binds to multiple sites in the 3′‐UTR of ATG12 resulting in overexpression. PTBP3 increases cancer cell proliferation and autophagic flux in response to hypoxic stress, which contributes to gemcitabine resistance.
Disseminating TF‐CBT: A Mixed Methods Investigation of Clinician Perspectives and the Impact of Training Format and Formalized Problem‐Solving Approaches on Implementation Outcomes
Authors: Ascienzo Sarah , Sprang Ginny , Eslinger Jessica 
Published: January 2020

AbstractBackgroundTrauma Focused‐Cognitive Behavioural Therapy (TF‐CBT) has been established as an evidence‐based treatment for youth with traumatic stress symptoms. The versatility of TF‐CBT in conjunction with its established effectiveness has led to its widespread dissemination. However, dissemination efforts have not always translated into sustainability, which has prompted a more thorough investigation into those factors that impact implementation and encouraged the development of strategies that promote sustainability. Toward this end, the aims of this study were to: (1) determine which components of TF‐CBT clinicians found the most difficult to implement; (2) explore clinicians’ perceptions as to why these components were challenging; and (3) examine whether the use of formalized problem‐solving approaches (FPSAs) or training format was associated with implementation outcomes.MethodsA mixed methods design was utilized to analyse survey data from mental health professionals (N = 85) who received TF‐CBT training. Thematic analysis explored responses to questions concerning those TF‐CBT components respondents found most difficult to implement, while bivariate analyses helped determine whether training format or the use of FPSAs was associated with training engagement, confidence in delivering TF‐CBT, fidelity or sustainability.ResultsClinicians perceived the same three components of TF‐CBT as most difficult regardless of the type of training they received, and provider, youth, caregiver, and organizational‐related themes emerged from thematic analysis. Bivariate analyses indicated more extended training formats and the use of FPSAs were associated with greater implementation success.ConclusionFindings suggest that perceived difficulty of TF‐CBT components did not vary by training format, but more extended formats and the use of FPSAs were associated with more favourable implementation outcomes. Implementers should consider ways to utilize FPSAs within training programs, as well as focus on content identified by clinicians as difficult, as this may assist clinicians in developing skills and managing implementation barriers.
Impacts of broadband and selected infrared wavelength treatments on inactivation of microbes on rough rice
Authors: Oduola Abass A. , Bowie Rebecca , Wilson Shantae A. , Mohammadi Shad Zeinab , Atungulu Griffiths G. 
Published: January 2020

AbstractThis study investigated the effects of broadband and selected infrared (IR) wavelength treatments of rough rice on microbial inactivation. Rough rice was treated at different IR wavelengths and product‐to‐emitter distances (110, 275, and 440 mm) followed by tempering at 60°C for 4 hr. The total mold and aerobic plate counts (APC) on non‐treated and treated samples were determined. Significant total mold reductions of 1.14 and 3.11 log CFU/g were obtained after IR heating using broadband and selected wavelengths, respectively (p < .05). The most significant reduction of APC using selected IR wavelength was 1.09 log CFU/g; the broadband IR wavelength had no effect on the mean APC. The IR treatments followed by tempering step resulted in greater reductions of total mold counts and APC (4.03 and 3.50 log CFU/g) in comparison to IR treatments without tempering (3.11 and 1.09 log CFU/g). Overall, bacteria showed more resistance to IR treatments than molds.
Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults
Authors: Maltais Mathieu , de Souto Barreto Philipe , Perus Lisa , Mangin Jean‐François , Grigis Antoine , Chupin Marie , Bouyahia Ali , Gabelle Audrey , Delrieux Julien , Rolland Yves , Vellas Bruno ,   for the Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer (MAPT/DSA) Study Group
Published: January 2020

BACKGROUNDCross‐sectional associations have been found between frail individuals and worse white matter (WM) integrity. However, the prospective association between WM integrity and frailty is still unclear. Our objectives were to measure associations between WM integrity using diffusion tensor imaging (DTI) and the 5‐year worsening of frailty in community‐dwelling older adults.DESIGNSecondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT).SETTINGThirteen memory centers in France and Monaco between 2008 and 2011.PARTICIPANTSParticipants (mean age = 74.7 ± 3.9 years) with no dementia at baseline who had functional magnetic resonance imaging performed as part of the MAPT study (n = 227).MEASUREMENTSFractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) were acquired for 10 different brain regions. Frailty was assessed by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven time points for 5 years. Mixed effect ordinal logistic regression model was used to assess the prospective association between DTI parameters (independent variables) and frailty (dependent variable). All the analyses were adjusted for age, sex, baseline total intracranial volume, and the presence of one of the following cardiovascular risk factors (hypertension, diabetes, and/or hypercholesterolemia).RESULTSA statistically significant association was found between the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) and worsening of frailty over 5 years after adjusting for multiple comparisons.CONCLUSIONSThis is the first study to show that WM integrity is associated with frailty in older adults. The mechanisms related to these results require further investigation. J Am Geriatr Soc 68:1050–1055, 2020