bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Clinical Trial of Inreach With or Without Mailed Outreach to Promote Hepatitis C Screening in a Difficult-to-Reach Patient Population
Authors: Desai Nirali , Rich Nicole E. , Jain Mamta K. , Blackwell James-Michael , Murphy Caitlin C. , Perryman Patrice , McBryde Jennifer , Quirk Lisa , Clark Christopher , Villarreal Deyaun , Waljee Akbar K. , Gopal Purva , Singal Amit G. 
Published: December 2020

INTRODUCTION:
Hepatitis C virus (HCV) treatment can significantly reduce the risk of liver-related mortality; however, many patients remain unaware of their infection in clinical practice. The aim of this study is to compare the effectiveness of inreach, with and without mailed outreach, to increase HCV screening and follow-up in a large, difficult-to-reach patient population.

METHODS:
We conducted a pragmatic randomized clinical trial from August 2018 to May 2019 in a large safety-net health system. Patients born between 1945 and 1965 were randomly assigned (1:1) to inreach with an electronic health record reminder to providers (n = 6,195) or inreach plus mailed HCV screening outreach (n = 6,191) to complete HCV antibody screening. Outreach also included processes to promote HCV RNA testing among those with a positive HCV antibody and linkage to care among those with positive HCV RNA. The primary outcome was completion of HCV antibody testing within 3 months of randomization (ClinicalTrials.gov NCT03706742).

RESULTS:
We included 12,386 eligible patients (median age 60 years; 46.5% Hispanic, 33.0% Black, and 16.0% White). In intent-to-treat analyses, HCV screening completion was significantly higher among inreach-plus-outreach patients than inreach-alone patients at 3 months (14.6% vs 7.4%, P < 0.001) and 6 months (17.4% vs 9.8%, P < 0.001) after randomization. Among those who completed HCV screening within 6 months, a higher proportion of inreach-plus-outreach patients with positive antibody results completed RNA testing within 3 months than inreach-alone patients (81.1% vs 57.1%, respectively, P = 0.02); however, linkage to care within 3 months of HCV infection confirmation did not significantly differ between the 2 groups (48.1% vs 75.0%, respectively, P = 0.24).

DISCUSSION:
Among difficult-to-reach patients, a combination of inreach and mailed outreach significantly increased HCV screening compared with inreach alone. However, HCV screening completion in both arms remained low, highlighting a need for more intensive interventions.
Sex-Associated Gene Expression Alterations Correlate With Esophageal Cancer Survival
Authors: Weygant Nathaniel , Chang Karen , Jackson Christian S. , Vega Kenneth J. 
Published: December 2020

OBJECTIVES:
Esophageal cancer (EC) is a significant cause of cancer death with 5-year survival of 10%–15% and males more frequently affected. Genetic evaluation for loci highlighting risk has been performed, but survival data are limited. The Cancer Genome Atlas (TCGA) data sets allow for potential prognostic marker assessment in large patient cohorts. The study aimed to use the TCGA EC data set to assess whether survival varies by sex and explore genetic alterations that may explain variation observed.

METHODS:
TCGA clinical/RNA-seq data sets (n = 185, 158 males/27 females) were downloaded from the cancer genome browser. Data analysis/figure preparation was performed in R and GraphPad Prism 7. Survival analysis was performed using the survival package. Text mining of PubMed was performed using the tm, RISmed, and wordcloud packages. Pathway analysis was performed using the Reactome database.

RESULTS:
In EC, male sex/high tumor grade reduced overall survival (hazard ratio = 2.27 [0.99–5.24] for M vs F and 2.49 [0.89–6.92] for low vs high grade, respectively) and recurrence-free survival (hazard ratio = 4.09 [0.98–17.03] for M vs F and 3.36 [0.81–14.01] for low vs high grade, respectively). To investigate the genetic basis for sex-based survival differences in EC, corresponding gene expression data were analyzed. Sixty-nine genes were dysregulated at the P < 0.01 level by the Wilcox test, 33% were X-chromosome genes, and 7% were Y-chromosome genes.

DISCUSSION:
Female sex potentially confers an EC survival advantage. Importantly, we demonstrate a genetic/epigenetic basis for these survival differences that are independent of lifestyle-associated risk factors overrepresented in males. Further research may lead to novel concepts in treating/measuring EC aggressiveness by sex.
Bleeding After Elective Interventional Endoscopic Procedures in a Large Cohort of Patients With Cirrhosis
Authors: Kundumadam Shanker , Phatharacharukul Parkpoom , Reinhart Kathryn , Yousef Andrew , Shamseddeen Hani , Pike Francis , Patidar Kavish R. , Gromski Mark , Chalasani Naga , Orman Eric S. 
Published: December 2020

INTRODUCTION:
Elective therapeutic endoscopy is an important component of care of cirrhotic patients, but there are concerns regarding the risk of bleeding. This study examined the incidence, risk factors, and outcomes of bleeding after endoscopic variceal ligation (EVL), colonoscopic polypectomy, and endoscopic retrograde cholangiopancreatography with sphincterotomy in cirrhotic patients.

METHODS:
A cohort study of patients with cirrhosis who underwent the above procedures at a single center between 2012 and 2014 was performed. Patients with active bleeding at the time of procedure were excluded. Patients were followed for 30 days to assess for postprocedural bleeding and for 90 days for mortality.

RESULTS:
A total of 1,324 procedures were performed in 857 patients (886 upper endoscopies, 358 colonoscopies, and 80 endoscopic retrograde cholangiopancreatograpies). After EVL, bleeding occurred in 2.8%; after polypectomy, bleeding occurred in 2.0%; and after sphincterotomy, bleeding occurred in 3.8%. Independent predictors of bleeding after EVL and polypectomy included younger age and lower hemoglobin. For EVL, bleeding was also associated with infection and model for end-stage liver disease-Na. International normalized ratio was associated with bleeding in univariate analysis only, and platelet count was not associated with bleeding in any procedure. Bleeding after EVL was associated with 29% 90-day mortality, and bleeding after polypectomy was associated with 14% mortality. Of the 3 patients with postsphincterotomy bleeding, none were outliers regarding their baseline characteristics.

DISCUSSION:
In patients with cirrhosis, bleeding occurs infrequently after elective therapeutic endoscopy and is associated with younger age, lower hemoglobin, and high mortality. Consideration of these risk factors may guide appropriate timing and preprocedural management to optimize outcomes.
A bibliography experiment on research within the scope of industry 4.0 application areas in sports
Authors: Ünlü Yılmaz , Taş Zeki 
Published: December 2020

Developed countries develop their production sites within the scope of industry 4.0 technology components and experience constant change and transformation to establish economic superiority. This situation allows them to produce more in various fields and thus to rise to a more advantageous position economically. Industry 4.0 technology affects areas within the scope of the sports industry such as sports tourism, athlete performance, athlete health, sports publishing, sports textile products, sports education and training, sports management and human resources, and creates an international competition environment in terms of production and performance. In this study, it is aimed to examine the researches about the usage areas of industry 4.0 in sports. From this point on, researches in the context of the subject have been presented with bibliographic method. In the conclusion section, the weaknesses and possibilities of youth sociology were discussed, and efforts were made to present a projection on what to do about the field. In this respect, a youth sociology evaluation has been tried to be made on the prominent topics, forgotten aspects and themes left incomplete in youth sociology studies. ​Extended English summary is in the end of Full Text PDF (TURKISH) file. Özet Gelişmiş ülkeler endüstri 4.0 teknolojisi bileşenleri kapsamında üretim sahalarını geliştirmekte ve ekonomik üstünlük kurmak amacıyla sürekli değişim ve dönüşüm yaşamaktadır. Bu durum onların çeşitli alanlarda daha fazla üretmelerine dolayısıyla ekonomik yönden daha avantajlı konuma yükselmelerine olanak sağlamaktadır. Endüstri 4.0 teknolojisi spor turizmi, sporcu performansı, sporcu sağlığı, spor yayıncılığı, spor tekstil ürünleri, spor eğitimi ve öğretimi, spor yönetimi ve insan kaynakları gibi spor endüstrisi kapsamındaki alanları etkilemekte üretim ve performans yönünden ülkeler arası bir rekabet ortamı oluşturmaktadır. Bu çalışmada endüstri 4.0’ın sporda kullanım alanları ile ilgili araştırmaların incelenmesi hedeflenmektedir. Bu noktadan hareketle konu bağlamındaki araştırmalar bibliyografik metodla ortaya konmuştur. Sonuç bölümünde ise sporda endüstri 4.0 kullanım alanları tartışılmış, alana olan katkıları ve olumuz etkilerinin değerlendirilmesi yapılmıştır.
Is the OUTPUT Sports Unit Reliable and Valid When Estimating Back Squat and Bench Press Concentric Velocity?
Authors: Merrigan Justin J. , Martin Joel R. 
Published: December 2020

Abstract
Merrigan, JJ and Martin, JR. Is the OUTPUT sports unit reliable and valid when estimating back squat and bench press concentric velocity? J Strength Cond Res 36(8): 2069–2076, 2022—This study evaluated the reliability and concurrent validity of the OUTPUT sports inertial unit to measure concentric velocity of free-weight back squat and bench press exercises. Eleven men and women performed back squat and bench press 1 repetition maximum (1RM) testing. One week later, subjects performed 3 repetitions of each exercise with 35, 45, 55, 65, 75, and 85% 1RM (18 total repetitions). The OUTPUT and 4 cable extension transducers (criterion) simultaneously recorded the mean and peak velocity. The OUTPUT had acceptable reliability for all loads except 85% 1RM for back squat and bench press (intraclass correlation coefficient = 0.72–0.96, coefficient of variation = 0.03–0.12). High systematic biases existed for the mean and peak velocity for the back squat and bench press, according to Bland-Altman plot's wide limits of agreement and ordinary least products regressions. According to Bland-Altman plots, OUTPUT tended to overestimate bench press velocity and overestimate back squat velocity at slower velocities. Least products regression analyses determined proportional bias existed for the mean and peak velocity of the back squat and peak velocity of the bench press. In conclusion, researchers and practitioners are advised not to compare velocity estimates of the OUTPUT unit with criterion devices because these methods cannot be used interchangeably. However, because of the demonstrated reliability when estimating the mean and peak velocity, strength and conditioning practitioners may find the OUTPUT unit valuable for monitoring performance of the back squat and bench press exercises. Yet, caution should be taken when evaluating loads ≥85% 1RM.
Correlations Between Jump Performance in Block and Attack and the Performance in Official Games, Squat Jumps, and Countermovement Jumps of Professional Volleyball Players
Authors: Berriel Guilherme P. , Schons Pedro , Costa Rochelle R. , Oses Victor Hugo S. , Fischer Gabriela , Pantoja Patrícia D. , Kruel Luiz Fernando M. , Peyré-Tartaruga Leonardo A. 
Published: December 2020

Abstract
Berriel, GP, Schons, P, Costa, RR, Oses, VHS, Fischer, G, Pantoja, PD, Kruel, LFM, and Peyré-Tartaruga, LA. Correlations between jump performance in block and attack and the performance in official games, squat jumps, and countermovement jumps of professional volleyball players. J Strength Cond Res 35(12S): S64–S69, 2021—The jump used in performance tests must be chosen according to the specificity. The aims of the present study were to analyze the correlations between height and reach of block and attack jumps and the effectiveness of such actions in official games and also the relationship between height and reach of attack and block jumps and the height achieved in squat jump (SJ), countermovement jump (CMJ), and CMJ with an arms swing (CMJA). Thirteen, male, professional volleyball players who competed in the Brazilian Volleyball Super League participated in this study. Evaluations of height and reach of attack and block jumps and height of SJ, CMJ, and CMJA were performed. Attack and block effectiveness were evaluated in 8 official games. Pearson's product-moment correlation coefficient was used, and the significance level was set at α ≤ 0.05. Attack jump height correlated with attack effectiveness in the games (r = 0.57; p = 0.05). Block jump height presented a very large correlation with SJ height (r = 0.82; p < 0.01), and attack jump height presented a very large correlation with CMJ height (r = 0.86; p < 0.01). Success in attack actions is directly associated with the athlete's ability to perform a vertical jump. Moreover, SJ, CMJ, and CMJA tests provided information of great applicability for the volleyball players' needs. Because of the relevance of the results, these tests should be included in the assessment routine of professional volleyball players.
Muscle Strength Does Not Adapt From a Second to Third Bout of Eccentric Contractions: A Systematic Review and Meta-Analysis of the Repeated Bout Effect
Authors: Lindsay Angus , Abbott Gavin , Ingalls Christopher P. , Baumann Cory W. 
Published: December 2020

Abstract
Lindsay, A, Abbott, G, Ingalls, CP, and Baumann, CW. Muscle strength does not adapt from a second to third bout of eccentric contractions: A systematic review and meta-analysis of the repeated bout effect. J Strength Cond Res 35(2): 576–584, 2021—The greatest muscle strength adaptations to repeated bouts of eccentric contractions (ECC) occur after the initial injury, with little to no change in subsequent bouts. However, because of the disparity in injury models, it is unknown whether three or more bouts provide further adaptation. Therefore, we performed a systematic review of the literature to evaluate whether a third bout of skeletal muscle ECC impacts immediate strength loss and rate of strength recovery compared with a second bout. A search of the literature in Web of Science, SCOPUS, Medline, and the American College of Sports Medicine database was conducted between May and September 2019 using the keywords eccentric contraction or lengthening contraction and muscle and repeated or multiple, and bout. Eleven studies with 12 experimental groups, using 72 human subjects, 48 mice, and 11 rabbits, met the inclusion criteria. A meta-analysis using a random effects model and effect sizes (ESs; Hedges' g) calculated from the standardized mean differences was completed. Calculated ESs for immediate strength loss provided no evidence that a third bout of ECC results in greater loss of strength compared with a second bout (ES = −0.12, 95% confidence interval [CI] = −0.41 to 0.17). Furthermore, the rate of strength recovery was not different between a second and third bout (ES = −0.15, 95% CI = −1.01 to 0.70). These results indicate a third bout of skeletal muscle ECC does not improve indices of strength loss or rate of strength recovery compared with a second bout. Therefore, coaches and athletes should expect some level of persistent weakness after each of their initial training sessions involving ECC, and the faster recovery of strength deficits in the second bout documented by previous research is not different from a third bout.
Step vs. Two-Phase Gradual Volume Reduction Tapering Protocols in Strength Training: Effects on Neuromuscular Performance and Serum Hormone Concentrations
Authors: Stina Seppänen , Häkkinen Keijo 
Published: December 2020

Abstract
Seppänen, S and Häkkinen, K. Step vs. two-phase gradual volume reduction tapering protocols in strength training: Effects on neuromuscular performance and serum hormone concentrations. J Strength Cond Res 36(10): 2771–2779, 2022—This study assessed effects of 2 reduced volume tapering protocols on neuromuscular performance and serum hormone concentrations in 14 recreationally strength-trained men (21–30 years). After an 8-week strength training period subjects were divided to the step (54% volume reduction immediately) and 2-phase gradual (38% reduction for the first week and 70% for the second week) tapering groups for 2 weeks. One repetition maximum (1RM) squat, maximal isometric bilateral leg press force (leg press MVIC), electromyography (EMG) of vastus lateralis (VL) and vastus medialis, cross-sectional area of VL, serum testosterone, cortisol, and sex hormone-binding globuline (SHBG) concentrations were measured before and repeatedly during training and tapering periods. Both tapering protocols led to significant increases (p < 0.01) in squat 1RM. However, the increase in the step group (3.4 ± 2.1%) was higher (p < 0.05) than in the gradual group (1.7 ± 0.9%). The maximal integrated EMG of VL increased (p < 0.05) during tapering in the step group. Serum testosterone concentration increased (p < 0.05) and T/SHBG ratio reached the highest level after 1-week tapering in the step group. In the gradual group, T/SHBG ratio was (p < 0.05) higher after the taper than after the training period. Individual changes in T/SHBG ratio in the total group correlated positively (p < 0.05) with individual changes in leg press MVIC during the taper. These results suggest that reducing training volume can be an effective way to peak maximal strength. However, a higher volume reduction rate at the beginning of taper seems to lead to more favorable changes in maximal strength accompanied by positive changes in the neuromuscular system and serum hormone concentrations when taper follows an overreaching period.
The Effect of Game-Related Contextual Factors on Sleep in Basketball Players
Authors: Fox Jordan L. , Scanlan Aaron T. , Stanton Robert , Sargent Charli 
Published: December 2020

Abstract
Fox, JL, Scanlan, AT, Stanton, R, and Sargent, C. The effect of game-related contextual factors on sleep in basketball players. J Strength Cond Res 36(10): 2942–2945, 2022—The purpose of this study was to determine whether contextual factors including game location, game outcome, and score-line margin influence subsequent nightly sleep duration and quality in basketball players. Seven semiprofessional, male basketball players were monitored across one competitive season using self-reported sleep diaries and activity monitors. Linear mixed models and effect sizes (ESs) were used to compare sleep duration and quality following games based on game location (played at home or away venues), game outcome (win or loss), and score-line margin (balanced [≤ 8-point margin] or unbalanced [≥ 9-point margin]). Sleep onset was later following away games (ES = 0.79 ± 0.86 [moderate], p = 0.12), losses (ES = 0.63 ± 0.79 [moderate], p = 0.18), and unbalanced games (ES = 1.36 ± 0.90 [large], p = 0.01). Wake time was later following losses (ES = 1.14 ± 0.85 [moderate], p = 0.02). Sleep fragmentation was higher following wins (ES = 0.65 ± 0.74 [moderate], p = 0.17). Sleep efficiency was higher following losses (ES = 0.70 ± 0.80 [moderate], p = 0.14). All other differences in sleep variables yielded trivial-small ESs (p > 0.05). Because of the later sleep onset times of players, basketball practitioners should consider avoiding early morning travel or training sessions following away games, losses, and unbalanced games, to maintain similar nightly sleep durations in light of the contextual factors encountered. Basketball practitioners may also need to ensure player sleep is optimized following wins compared with losses given the lower quality observed.
Effects of lifestyle factors on fertility: practical recommendations for modification
Authors: Emokpae Mathias Abiodun , Brown Somieye Imaobong 
Published: December 2020

The role that lifestyle factors play in fertility issues has generated some amount of interest and questions among stakeholders. This review aims to highlight the impact of lifestyle behaviors on the fertility potential of an individual and what can be done to prevent or improve reproductive outcomes. Relevant published articles on the effect of lifestyle behaviors were obtained from Medline, Pubmed and Google scholar search engines for the study. The review of the literature indicates a negative impact of modifiable lifestyle factors such as fat-rich diets, delayed childbearing/age of starting family, smoking, alcohol misuse, sexual behavior, anxiety/depression and perception/beliefs were associated with fertility. The ensuing stress precipitates social behaviors such as excessive alcohol and caffeine consumption, tobacco smoking, misuse of recreational drugs/medications, which increases the risk of sexually transmitted diseases and infection leading to infertility. Practical recommendations to modify lifestyle behaviors and the impact of misconception of Assisted Reproductive Technology in the treatment of infertility are discussed. The need to make appropriate behavioral changes to stem the tide of infertility in Nigeria is imperative. More reproductive health education is needed to create the necessary awareness of the etiologies of infertility and the importance of in vitro fertilization treatment as a means of conceiving ‘natural’ babies is suggested.

Lay summary
Scientific evidence has suggested that modifiable lifestyle factors (consumption fat-rich diets, delayed childbearing/age of starting family, smoking, alcohol misuse, sexual behavior, anxiety/depression and perception/beliefs) play important roles in the general health and wellbeing of individuals including fertility. Evidence exists of an association between lifestyle behaviors and infertility in both men and women. Understanding the various processes through which modifiable lifestyle behaviors impair fertility will help to assist in the management of affected individuals. We conducted a comprehensive review of published studies to assess how lifestyle factors inhibit fertility and practical ways to ameliorate them. This review also deals with the misconception of Assisted Reproductive Technology in the treatment of infertility. The need to make appropriate behavioral changes to stem the tide of infertility in Nigeria is imperative. More reproductive health education is needed to create the necessary awareness of the causes of infertility and the importance of in vitro fertilization in the treatment of infertility.
HPV pozitif olan hastaların HPV hakkında bilgileri ve HPV aşılarına yaklaşımı: Tersiyer bir merkezin deneyimi
Authors: PURUT Yunus Emre , PURUT Şeyma Nur , GİRAY Burak , YAZICI Zeliha , KABACA Canan 
Published: December 2020

Amaç: Tersiyer bir merkeze kolposkopik inceleme için refere edilen hastaların Human Papillomavirus (HPV) hakkındaki bilgilerini ve HPV aşısına yaklaşımını değerlendirmeyi amaçladık.
Gereç ve yöntem: 01.12.2018 ile 01.05.2019 tarihleri arasında üçüncü basamak sağlık kuruluşunda kolposkopik inceleme yapılan 197 HPV pozitif hasta çalışmaya dahil edildi.
Bulgular: Hastaların yaş ortalamaları 38,60±8,78 idi. Hastaların yaklaşık %56,9’unun HPV aşısı hakkında bilgisi olmasına rağmen, %86,8’i her kadının aşı yaptırması gerektiğini düşünmüyordu. HPV aşısı yaptırmama sebebi olarak da hastaların %40,6’sı hekimlerin aralarında bir fikir birliği olmadığını söylemiştir. HPV hakkında önceden bilgi sahibi olan ile olmayan hastalar arasında eğitim durumu açısından istatiksel bir farklılık bulunmamıştır (p=0,291). HPV hakkında önceden bilgisi olanların %55,7’si düzenli smear yaptırdığını bildirmiştir. HPV hakkında bilgisi olan hastalar ile olmayan hastalar arsında düzenli smear taraması yaptırması açısından anlamlı fark vardı (p=0,001).
Sonuç: Hastaların HPV hakkında bilgisi olduğu halde HPV aşısının güvenliği ve aşının koruması hakkında endişeye sahiptiler.