bluuebunny/crossref_metadata_2025_split huggingface dataset:
Additive prognostic value of carbohydrate antigen‐125 over frailty in patients undergoing transcatheter aortic valve replacement
Authors: Romeo Francisco José , Seropian Ignacio Miguel , Chiabrando Juan Guido , Raleigh Juan Valle , Smietniansky Maximiliano , Cal Mariela , Falconi Mariano , Kotowicz Vadim , Agatiello Carla Romina , Berrocal Daniel Horacio 
Published: June 2020

AbstractBackgroundTo evaluate the additive prognostic value of myocardial, inflammatory, and renal biomarkers according to frailty status in patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS).MethodsA total of 111 subjects who underwent TAVR at Hospital Italiano de Buenos Aires, Argentina between January 2016 and December 2018 were retrospectively reviewed. Plasma levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), high sensitivity troponin T (hs‐cTnT), C‐reactive protein (CRP), cystatin‐c (Cys‐C) and carbohydrate antigen‐125 (CA‐125) were assessed prior to TAVR. Frailty status was assessed according to the fried physical frailty phenotype (FPFP). The primary endpoint was defined as all‐cause death and/or readmission for worsening congestive heart failure (CHF) within the first year after TAVR.ResultsOf the 111 patients included, 48/111 (43%) were considered to be “frail” according to the FPFP. Among biomarkers, we found CA‐125 to be strongly associated with the primary endpoint (p = .006). CA‐125 ≥ 18.2 U/ml was present in 41% and was associated with a higher rate of the primary endpoint (31% vs. 9%; p = .003). After multivariable adjustment, CA‐125 ≥ 18.2 U/ml (hazard ratio [HR] 3.17; p = .024) was the only independent predictor of the primary endpoint. Finally, the inclusion of CA‐125 to frailty significantly improved C‐index (0.68–0.74; p < .05), and provided a Net Reclassification Improvement (NRI) of 0.34 (95% CI 0.19–0.49, p = .031), largely through reductions in risk estimates among pre‐frail and frail patients.ConclusionsCA‐125, a tumor biomarker, outperformed frailty for predicting the primary endpoint within the first year after TAVR.
Equipment utilization in chronic total occlusion percutaneous coronary interventions: Insights from the PROGRESS‐CTO registry
Authors: Nikolakopoulos Ilias , Choi James W. , Alaswad Khaldoon , Khatri Jaikirshan J. , Krestyaninov Oleg , Khelimskii Dmitrii , Yeh Robert W. , Jaffer Farouc A. , Toma Catalin , Patel Mitul , Mahmud Ehtisham , Lembo Nicholas J. , Parikh Manish , Kirtane Ajay J. , Ali Ziad A. , Gkargkoulas Fotis , Uretsky Barry , Sheikh Abdul M. , Vemmou Evangelia , Xenogiannis Iosif , Rangan Bavana V. , Garcia Santiago , Abdullah Shuaib , Banerjee Subhash , Burke M. Nicholas , Brilakis Emmanouil S. , Karmpaliotis Dimitri 
Published: June 2020

AbstractBackgroundWe examined guidewire and microcatheter utilization during chronic total occlusion (CTO) percutaneous coronary intervention (PCI).MethodsWe examined device utilization in 2,968 CTO PCIs performed in 2,936 patients at 19 US and two international center between January 2016 and January 2019.ResultsThe median number of antegrade guidewires used per case declined (5 in 2016 vs 3 in 2019) and was higher in higher complexity lesions (2 in J‐CTO 0 vs. 8 in J‐CTO 4 or 5 score). In antegrade‐only procedures, the most frequently used guidewires were the Pilot 200 (Abbott Vascular, 37%), Fielder XT (Asahi Intecc, 25%) and Gaia third (Asahi Intecc, 18%), while the most commonly used microcatheters were the Turnpike Spiral (Vascular Solutions, 18%) and Turnpike (Vascular Solutions, 16%). Compared with 2012–2015, during 2016–2019 use of novel equipment such as the Gaia guidewires and the Turnpike microcatheters led to decreased use of Confianza Pro 12 (Asahi Intecc) wire and Corsair (Asahi Intecc) family of microcatheters. In retrograde cases, the guidewires most commonly used were the Sion (44%), Pilot 200 (27%) and Fielder FC (26%), while the Corsair/Corsair Pro, Turnpike LP (Vascular Solutions) and Caravel (Asahi Intecc) were the most frequently used microcatheters for collateral crossing (29%, 26% and 22%, respectively).ConclusionsThe most commonly used guidewires during CTO PCI are polymer‐jacketed guidewires and the most commonly used microcatheters are torquable microcatheters.
An unusual presentation of acquired periungual fibrokeratoma: A mixed form of dome‐shaped and branching type
Authors: Sung Kun‐Yong , Lee SeungKoo , Lee Sang‐Yeul 
Published: June 2020

AbstractAcquired periungual fibrokeratoma is an uncommon benign fibrous tumour occurring in the periungual area, predominantly the proximal nail fold. We describe a case of acquired periungual fibrokeratoma with an unusual presentation of mixed features including dome‐shaped and branching type in order to facilitate the recognition of this variant.
Efficient Electrocatalytic Performance of WP Nanorods Propagated on WS2/C for Hydrogen Evolution Reduction
Authors: Yang Jinzhou , Yu Zong‐Bao , Sun Wei , Li Yue , Wu Hongda , Geng Zhongxing , Yang Zhanxu 
Published: June 2020

AbstractThrough a stepwise synthesis, intercalation followed by chemical vapor deposition (CVD) method, WP nanorods have been grown on the surface of WS2/C composite. Compared to WS2/C, WP nanorods@WS2/C demonstrate better hydrogen evolution reaction (HER) activity and long‐term chronopotentiometric stability as well as suitability in both acid electrolyte and alkaline electrolyte. In order to uncover the enhanced HER property reason, systematic characterizations were applied to assist analyzing. The characterizations used include X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X‐ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), electrochemical active surface area (ECSA), Raman, and BET. Based on the analysis, it points that improved ECSA, synergy between WS2 and WP nanorods, and enhanced degree of graphitization as well, leads to better HER activities of WP nanorods@WS2/C over WS2/C. This work highlights significant role of WP nanorods in WP/WS2/C three‐phase composite in electrocatalytic hydrogen evolution and may evoke new interest in related nanostructure study.
Insights into Ruthenium(II/IV)‐Catalyzed Distal C−H Oxygenation by Weak Coordination
Authors: Bu Qingqing , Kuniyil Rositha , Shen Zhigao , Gońka Elżbieta , Ackermann Lutz 
Published: June 2020

AbstractC−H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O‐coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)‐catalyzed C−H oxygenation of aryl acetamides proceeded through C−H activation, ruthenium(II/IV) oxidation and reductive elimination, thus providing step‐economical access to valuable phenols. The p‐cymene‐ruthenium(II/IV) manifold was established by detailed experimental and DFT‐computational studies.
Residence Time Characteristics of the Novel Archimedean Screw Crystallizer/Reactor
Authors: Meise Marius , Jäger Luca , Wilk Andreas , Heitmann Torsten , Scholl Stephan 
Published: June 2020

AbstractThis work presents a novel design of a continuous crystallizer, the Archimedean screw crystallizer reactor (ASKR) with integrated Archimedean screw as conveying element. By the screw, the axial motion of the product solution is initiated, and an undesired axial mixing is restricted. This structure results in a narrow residence time distribution and, thus, promotes a defined product quality. In order to quantitatively assess the flow characteristics of the crystallizer and to highlight the influence of variable operating parameters such as rotational speed and volumetric flow, investigations of the residence time behavior with variation of the operating parameters are reported.
Immunocytochemistry practices in European cytopathology laboratories—Review of European Federation of Cytology Societies (EFCS) online survey results with best practice recommendations
Authors: Srebotnik Kirbiš Irena , Rodrigues Roque Rúben , Bongiovanni Massimo , Strojan Fležar Margareta , Cochand‐Priollet Béatrix 
Published: June 2020

BackgroundVariability in preanalytical and analytical steps for immunocytochemistry (ICC) on cytology samples is poorly defined. The objective of this study was to evaluate current practices for ICC on cytology samples in European laboratories.MethodsA link to an online survey with 19 questions about ICC practices was distributed to cytology laboratories through national representatives in the European Federation of Cytology Societies.ResultsIn total, 245 laboratories responded to the survey by January 30, 2019. Cell blocks, cytospins, liquid‐based cytology (LBC) preparations, and smears alone or in combination with other preparations were used for ICC in 38%, 22%, 21%, and 19% of laboratories, respectively. In general, various combinations of preparations were used for ICC in greater than one‐half of laboratories (147 of 245; 60%), whereas only 1 specific type of cytology preparation was used in the remaining 98 of 245 laboratories (40%) laboratories. The majority of laboratories (217 of 226; 96%) performed ICC on automated platforms using protocols that were the same as those used for formalin‐fixed, paraffin‐embedded samples (238 of 527 laboratories; 45%), either optimized (138 of 527 laboratories; 26%) or optimized and validated (151 of 527 laboratories; 29%) for cytology preparations. Positive control slides, negative control slides, and external quality control were used in 174 of 223 (78%), 112 of 223 (50%), and 111 of 120 (50%) laboratories, respectively. Greater than 1000 ICC tests were performed yearly in 34% of laboratories (65 of 191; average, 1477 tests; median, 500 tests).ConclusionsICC is extensively performed in European laboratories using variously prepared cytology preparations on automated platforms, mostly without quality‐assurance measures.
A Woven Supramolecular Metal‐Organic Framework Comprising a Ruthenium Bis(terpyridine) Complex and Cucurbit[8]uril: Enhanced Catalytic Activity toward Alcohol Oxidation
Authors: Zhang Yun‐Chang , Xu Zi‐Yue , Wang Ze‐Kun , Wang Hui , Zhang Dan‐Wei , Liu Yi , Li Zhan‐Ting 
Published: June 2020

AbstractThe self‐assembly of a diamondoid woven supramolecular metal–organic framework wSMOF‐1 has been achieved from intertwined [Ru(tpy)2]2+ (tpy=2,2′,6′,2′′‐terpyridine) complex M1 and cucurbit[8]uril (CB[8]) in water, where the intermolecular dimers formed by the appended aromatic arms of M1 are encapsulated in CB[8]. wSMOF‐1 exhibits ordered pore periodicity in both water and the solid state, as confirmed by a combination of 1H NMR spectroscopy, UV‐vis absorption, isothermal titration calorimetry, dynamic light scattering, small angle X‐ray scattering and selected area electron diffraction experiments. The woven framework has a pore aperture of 2.1 nm, which allows for the free access of both secondary and primary alcohols and tert‐butyl hydroperoxide (TBHP). Compared with the control molecule [Ru(tpy)2]Cl2, the [Ru(tpy)2]2+ unit of wSMOF‐1 exhibits a remarkably higher heterogeneous catalysis activity for the oxidation of alcohols by TBHP in n‐hexane. For the oxidation of 1‐phenylethan‐1‐ol, the yield of acetophenone was increased from 10 % to 95 %.
Internet of Things offloading: Ongoing issues, opportunities, and future challenges
Authors: Heidari Arash , Jabraeil Jamali Mohammad Ali , Jafari Navimipour Nima , Akbarpour Shahin 
Published: June 2020

SummaryInternet of Things (IoT) has very remarkable advantages over customary communication technologies. However, IoT suffers from different issues, such as limited battery life, low storage capacity, and little computing capacity. For this reason, in many IoT applications and devices, we require an alternative unit to execute the tasks from the user's device and return results. In general, the problem of limited resources by transferring the computation workload to other devices/systems with better resources is addressed by offloading computation. It can be focused on improving the application, extending battery life, or expanding storage capacity. The offloading operation can be performed based on various quality of service (QoS) parameters that contain computational demands for load balancing, response time, application, energy consumption, latency, and other things. Moreover, the systematic literature review (SLR) method is used to identify, assess, and integrate findings from all relevant studies that address one or more research questions on IoT offloading and conduct a comprehensive study of empirical research on offloading techniques. However, we present a new taxonomy for them based on offloading decision mechanisms and overall architectures. Furthermore, we offer a parametric comparison for the offloading methods. As well, we present the future direction and research opportunities in IoT offloading computation. This survey will assist academics and practitioners to directly understand the progress in IoT offloading.
Association of adiposity with diabetes: A national research among Chinese adults
Authors: Fu Wenning , Wang Chao , Zou Li , Jiang Heng , Miller Mia , Gan Yong , Cao Shiyi , Xu Hongbin , Mao Jing , Yan Shijiao , Yue Wei , Yan Feng , Tian Qingfeng , Lu Zuxun 
Published: June 2020

AbstractBackgroundAdiposity is an established risk factor for diabetes. The different measurements of adiposity for predicting diabetes have been compared in recent studies in Western countries. However, similar researches among Chinese adults are limited.MethodsData were collected from a national survey conducted during September 2014 and May 2015 Among Chinese adults aged 40 years and older across 30 China's provinces. Multilevel model analysis was performed to examine the impacts of different obesity indices [body mass index (BMI), waist circumference (WC), lipid accumulation product index (LAP), visceral adiposity index (VAI), and body adiposity index (BAI)] on the risk of diabetes.ResultsA total of 162 880 participants were included in this study. Of them, 54.47% were female. With an increase in BMI, WC, LAP, VAI, and BAI, the prevalence of diabetes significantly grew (P < 0.001). The multilevel model analysis showed that WC has the strongest impact on diabetes prevalence, while BAI was the weakest. For one SD increment in BMI, WC, LAP, VAI, and BAI, the prevalence of diabetes increased by 27.0% (Odds Ratio (OR) = 1.270, 95% Confidence interval (CI) = 1.251–1.289), 37.4% (OR = 1.374, 95% CI = 1.346–1.401), 28.1% (OR = 1.281, 95% CI = 1.266–1.297), 22.0% (OR = 1.220, 95% CI = 1.204–1.236), and 17.4% (OR = 1.174, 95% CI = 1.151–1.192), respectively.ConclusionObesity indicators of BMI, WC, LAP, VAI, and BAI have significant positive relationships with the risk of diabetes. WC has the strongest impact on diabetes, while BAI has the weakest.
Mapping and assessing the impact of small‐scale ephemeral water sources on wildlife in an African seasonal savannah
Authors: Naidoo Robin , Brennan Angela , Shapiro Aurelie C. , Beytell Piet , Aschenborn Ortwin , Du Preez Pierre , Kilian J. Werner , Stuart‐Hill Greg , Taylor Russell D. 
Published: June 2020

AbstractIn many savannah regions of Africa, pronounced seasonal variability in rainfall results in wildlife being restricted to floodplains and other habitats adjacent to permanent surface water in the dry season. During the wet season, rainfall fills small‐scale, ephemeral water sources that allow wildlife to exploit forage and other resources far from permanent surface water. These water sources remain difficult to quantify, however, due to their small and ephemeral nature, and as a result are rarely included in quantitative studies of wildlife distribution, abundance, and movement. Our goal was to map ephemeral water in Bwabwata National Park in Namibia using two different approaches and to relate measures of ephemeral water to the abundance, distribution, and movement of two large wildlife species. We used high‐resolution Google Earth and Esri World imagery to visually identify waterholes. Additionally, we used Sentinel‐2 satellite imagery to map ephemeral water across the study area using the Normalized Difference Water Index. With these mapped waterhole layers and data from GPS‐collared individuals of African elephant (Loxodonta africana) and African buffalo (Syncerus caffer), we evaluated the importance of ephemeral water in conditioning abundance and movement of these two species. The two approaches to mapping ephemeral water resulted in the visual identification of nearly 10,000 waterholes, and a predicted ephemeral water layer of ~76% accuracy. The inclusion of ephemeral water into models of abundance and movement resulted in improved goodness of fit relative to those without water, and water impacts on abundance and movement were among the strongest of all variables considered. The potential importance of ephemeral water in conditioning the movements and distributions of large herbivores in African savannahs has been difficult to quantify relative to vegetation drivers. Our results suggest research into ephemeral water impacts deserves more attention.
Impaired neuropsychological functioning in patients with hypopituitarism
Authors: Slagboom Tessa N. A. , Deijen Jan Berend , Van Bunderen Christa C. , Knoop Hans A. , Drent Madeleine L. 
Published: June 2020

AbstractBackgroundTreatment of pituitary pathology mostly does not result in complete recovery of impairment in cognitive functioning. The primary aim of the current study was to assess cognitive impairment in patients with stable replacement therapy for hypopituitarism during the last 6 months prior to inclusion. It was expected that patients showed subjective and objective subnormal scores on neuropsychological functioning.MethodsForty‐two patients (40% men, 49 ± 15 years) treated for hypopituitarism conducted a neuropsychological test battery, including the Cognitive Failures Questionnaire (CFQ), 15‐Word test (15‐WT), Cambridge Neuropsychological Test Automated Battery (CANTAB) Motor Screening Task (MOT), Spatial Working Memory (SWM) and Affective Go/No‐go (AGN). Results were compared to reference values of healthy norm groups.ResultsMale and female participants scored significantly worse on the CFQ (P < .01, d = 0.91‐4.09) and AGN mean correct latency (P < .01, d = 1.66 and 1.29, respectively). Female participants scored significantly worse on 15‐WT direct recall (P = .01, d = 0.66), 15‐WT delayed recall (P = .01, d = 0.79), SWM total errors (P = .05, d = 0.41), SWM strategy (P = .04, d = 0.43), AGN errors of commission (P = .02, d = 0.56) and omission (P = .04, d = 0.41).ConclusionThis study shows that subjective cognitive functioning is worse in patients treated for hypopituitarism compared to reference data. Also, female participants treated for hypopituitarism score worse on objective aspects of memory and executive functioning compared to reference data. Besides worse focus attention, this objective cognitive impairment was not found in male participants. It is recommended to conduct additional research, which focuses on the design and evaluation of a cognitive remediation therapy, aimed at compensation of impairments in different aspects of memory and executive functioning.
Effects of UV‐B radiation on soil carbon conversion and greenhouse gas emission in paddy soil
Authors: Li Tianguo , Li Xiang , Liang Yong , Li Mingrui , Jiang Ming , Zhan Fangdong , Li Yuan , He Yongmei 
Published: June 2020

AbstractThis paper evaluates the relationship between ultraviolet‐B (UV‐B, 280–315 nm) radiation enhancement on the earth's surface caused by ozone attenuation and climate change. A pot experiment was conducted to investigate the effects of enhanced UV‐B radiation on greenhouse gas (GHG) emissions from the paddy soil with rice straw incorporation (SI). The paddy soil was sampled from the Yuanyang Terrace, Yunnan Province, Southwest China. There were four treatments: natural light (control check, CK), 5.0 kJ·m−2 UV‐B radiation (UVB), SI, and SI + UVB. The effects of UV‐B radiation (5.0 kJ·m−2) on straw degradation, soil carbon invertase activity, active organic carbon content, and GHG emissions were studied. The results showed that UV‐B radiation promoted the degradation of straw components (lignin, cellulose, hemicellulose, and water‐soluble phenol). The SI treatment significantly increased the activity of soil carbon invertase (P < 0.05), the content of soil active organic carbon (P < 0.05), and the emission rates and amounts of GHGs (P < 0.05). Compared to the SI treatment, SI + UVB treatment reduced soil carbon invertase activity and active organic carbon content, resulting in a 17% reduction in CH4 emission and a 40% and 16% increase in CO2 and N2O emission (P < 0.05), but had no significant effect on the global warming potential (GWP). Correlation analysis showed that the degradation rate of straw components was positively correlated with the activity of carbon invertase, the contents of microbial biomass carbon (MBC), easily oxidized organic carbon (EOC), and the CO2 emission rate; the activities of sucrase and cellulase were positively correlated with the contents of MBC and EOC, which were in turn positively correlated with the emission rates of CH4 and CO2. Under SI, UV‐B radiation reduced the soil carbon conversion, which led to a decreased CH4 emission and increased emissions of CO2 and N2O, but did not alter the GWP of GHGs from the paddy soil. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.
Doubt, Disorientation, and Death in the Plague Time
Authors: Nelson Jamie Lindemann 
Published: June 2020

AbstractAn account of an experience with contracting an illness that may well have been Covid‐19 gives rise to reflections on doubt and on the art of dying well. The upshot: our mortality remains a fundamentally disorienting condition of our existence. If there's any wisdom to be had concerning our deaths, it likely lies in the direction of accepting their deranging character, rather than in searching for the philosophical insight that will reconcile us to our fate.
Learning from Covid
Authors: Hulkower Adira 
Published: June 2020

AbstractMrs. Clark's case was an ordinary consult in an extraordinary time. She was refusing dialysis, but the psychiatric unit had concluded that she lacked capacity for such decision‐making. The only difference between Mrs. Clark's current hospitalization and the last two was that it was April 2020 and a virus called Covid‐19 had overtaken our hospital. As the chief of Montefiore Medical Center's bioethics service, when I received a consult before the virus, I always saw the patient. Whether the patient had been in a vegetative state for a day or for years, it didn't matter. I would lay my hand on a leg or an arm and observe. But Covid‐19 enforced physical boundaries between my team and our patients; I would not be able to meet Mrs. Clark. Our hospital responded to the attack on human connection by getting creative. We asked ourselves, which tools are still available to us? Answering this involved, in part, finding new ways for our team of clinical ethicists to support the clinicians caring for Mrs. Clark.
Planetary Ethics: Russell Train and Richard Nixon at the Creation
Authors: Annas George J. 
Published: June 2020

AbstractThis piece offers a retrospective review of a plenary speech at the 1969 Annual Meeting of the American Public Health Association by the leading environmentalist of the Nixon administration, attorney and judge Russell Train. Train's talk, titled “Prescription for a Planet,” can be seen as an early argument for uniting environmental health and public health as the two main determinants of both individual and population health and for the inclusion of these fields in the then‐new field of “bioethics.”