bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polish adaptation and validation of the Perceived Implicit Rationing of Nursing Care (PIRNCA) questionnaire: a cross-sectional validation study
Authors: Uchmanowicz Izabella , Kołtuniuk Aleksandra , Młynarska Agnieszka , Łagoda Katarzyna , Witczak Izabela , Rosińczuk Joanna , Jones Terry 
Published: April 2020

ObjectivesTo develop a Polish adaptation of the Perceived Implicit Rationing of Nursing Care (PIRNCA)questionnaire.DesignCross-sectional validation study.SettingsNurses working in surgical and cancer wards in Poland.ParticipantsA sample of 513 professionally active nurses was enrolled in the study.InterventionTo complete a Polish translation of the full original PIRNCA questionnaire.Primary and secondary outcome measuresThe primary outcome was translation and adaptation of the full original PIRNCA tool and its validation to the Polish conditions. The secondary outcome was determination of relationships between sociodemographic variables, nurses’ assessment of patient care quality and their overall job satisfaction on the one hand, and PIRNCA scores on the other.ResultsThe respondents’ mean score was 1.27 points (SD=0.68) on a scale from 0 to 3. Cronbach’s alpha for the entire instrument was 0.957. All items of the questionnaire were found to have a positive item-total correlation. The developed linear regression model showed that nurses’ assessment of patient care quality and their overall job satisfaction were independent predictors of PIRNCA scores (p<0.05). 94.15% of nurses reported rationing at least one of the 31 care activities.ConclusionsThe present findings indicate a high level of reliability and validity of the translated PIRNCA questionnaire, fully comparable to that of the original. The questionnaire can be used for the assessment of PIRNCA in Polish hospitals.
ХАРАКТЕРИСТИКА ТЕРИТОРІАЛЬНОЇ ДОСТУПНОСТІ СІЛЬСЬКОМУ НАСЕЛЕННЮ ГІРСЬКОЇ І ПЕРЕДГІРСЬКОЇ ЗОН ПРОЖИВАННЯ ПЕРВИННОЇ ТА ДОЛІКАРСЬКОЇ МЕДИЧНОЇ ДОПОМОГИ
Authors: Rohach I. M. , Danko D. V. 
Published: April 2020

Мета: провести комплексну оцінку територіальної доступності сільському населенню гірської і передгірської зон Закарпатської області первинної та долікарської медичної допомоги.
Матеріали і методи. Матеріалами дослідження слугують дані державної та галузевої статистичної звітності за 2018 р., а методами – медико-статистичний метод та метод структурно-логічного аналізу.
Результати. у 349 селах гірської та передгірської зон Закарпатської області проживає 503,1 тис. осіб. Протяжність доріг складає 3814,0 км, із яких з асфальтним покриттям – 342,9 (8,99 %) км, а 1107,0 (29,02 %) км у зимовий, весняний і осінній періоди є умовно проїзними. У передгірській зоні в розрізі адміністративних територій відстань від районного центру до найвіддаленішого села коливається від 24,5 км у Свалявському до 70 км у Тячівському районі. У Тячівському районі 20 км є умовно проїзними у весняний, зимовий та осінній періоди. Це означає, що в цей період року ускладнюється доїзд до вказаних сіл бригад екстреної медичної допомоги та забезпечення госпіталізації хворих осіб.
У гірській географічній зоні в розрізі адміністративних територій відстань від районного центру до найвіддалені­шого села коливається від 29 км в Міжгірському до 51 км у Воловецькому районі. Із загальної кількості доріг 26,12 % є умовно проїзними у весняний, зимовий та осінній періоди.
Для надання долікарської допомоги відкрито 173 фельдшерсько-акушерських пункти та первинної лікарської допомоги – 157 сімейних лікарських амбулаторій.
У передгірській зоні для надання первинної медико-санітарної допомоги 371,8 тис. сільському постійному населенню відкрито 108 сімейних амбулаторій з рівнем забезпеченості 2,90 амбулаторій на 10 тис. населення.
У гірській зоні для надання первинної медико-санітарної допомоги 131,3 тис. сільському постійному населенню відкрито 49 сімейних амбулаторій з рівнем забезпеченості 3,73 амбулаторій на 10 тис. населення.
Висновки. Отримані результати вказують на низький рівень територіальної доступності сільському населенню гірської і передгірської зон Закарпатської області первинної та долікарської медичної допомоги.
Development of an autophagy-related gene expression signature for prognosis prediction in prostate cancer patients
Authors: Hu Daixing , Jiang Li , Luo Shengjun , Zhao Xin , Hu Hao , Zhao Guozhi , Tang Wei 
Published: April 2020

Abstract
Background
Prostate cancer (PCa) is one of the most prevalent cancers that occur in men worldwide. Autophagy-related genes (ARGs) may play an essential role in multiple biological processes of prostate cancer. However, ARGs expression signature has rarely been used to investigate the association between autophagy and prognosis in PCa. This study aimed to identify and assess prognostic ARGs signature to predict overall survival (OS) and disease-free survival (DFS) in PCa patients.

Methods
First, a total of 234 autophagy-related genes were obtained from The Human Autophagy Database. Then, differentially expressed ARGs were identified in prostate cancer patients based on The Cancer Genome Atlas (TCGA) database. The univariate and multivariate Cox regression analysis was performed to screen hub prognostic ARGs for overall survival and disease-free survival, and the prognostic model was constructed. Finally, the correlation between the prognostic model and clinicopathological parameters was further analyzed, including age, T status, N status, and Gleason score.

Results
The OS-related prognostic model was constructed based on the five ARGs (FAM215A, FDD, MYC, RHEB, and ATG16L1) and significantly stratified prostate cancer patients into high- and low-risk groups in terms of OS (HR = 6.391, 95% CI = 1.581– 25.840, P < 0.001). The area under the receiver operating characteristic curve (AUC) of the prediction model was 0.84. The OS-related prediction model values were higher in T3-4 than in T1-2 (P = 0.008), and higher in Gleason score  > 7 than  ≤ 7 (P = 0.015). In addition, the DFS-related prognostic model was constructed based on the 22 ARGs (ULK2, NLRC4, MAPK1, ATG4D, MAPK3, ATG2A, ATG9B, FOXO1, PTEN, HDAC6, PRKN, HSPB8, P4HB, MAP2K7, MTOR, RHEB, TSC1, BIRC5, RGS19, RAB24, PTK6, and NRG2), with AUC of 0.85 (HR = 7.407, 95% CI = 4.850–11.320, P < 0.001), which were firmly related to T status (P < 0.001), N status (P = 0.001), and Gleason score (P < 0.001).

Conclusions
Our ARGs based prediction models are a reliable prognostic and predictive tool for overall survival and disease-free survival in prostate cancer patients.
Surgery of ascending aorta with complex procedures for aortic dissection through upper mini-sternotomy versus conventional sternotomy
Authors: Wu Yang , Jiang Wei , Li Dong , Chen Lei , Ye Weihua , Ren Chonglei , Xiao Cangsong 
Published: April 2020

Abstract
Background
Use of minimally invasive approaches for isolated aortic valve or ascending aorta surgery is increasing. However, total arch replacement or aortic root repair through a minimally invasive incision is rare. This study was performed to report our initial experience with surgery of the ascending aorta with complex procedures through an upper mini-sternotomy approach.

Methods
We retrospectively analyzed 80 patients who underwent ascending aorta replacement combined with complex procedures including hemi-arch, total arch, and aortic root surgeries from September 2010 to May 2018. Using standard propensity score-matching analysis, 36 patients were matched and divided into 2 groups: the upper mini-sternotomy group (n = 18) and the median sternotomy group (n = 18). The preoperative assessment revealed no statistically significant differences between the two groups.

Results
Hospital mortality occurred in one patient (2.8%). The mini-sternotomy group showed a longer cross-clamping time (160 ± 38 vs. 135 ± 36 min, p = 0.048) due to higher rate of valve-sparing aortic root replacement and total arch repair. The cardiopulmonary bypass time in mini-sternotomy group was shorter than that of full sternotomy group (209 ± 47 min vs 218 ± 62 min, p = 0.595) but fell short of significance. There was no significant difference in lower body hypothermia circulatory arrest time between the two groups (40 ± 10 min vs 48 ± 20 min, p = 0.139). The upper mini-sternotomy group displayed a shorter ventilation time (22 vs. 45 h, p = 0.014), intensive care unit stay (4.6 ± 2.7 vs. 7.9 ± 3.7 days, p = 0.005), and hospital stay (8.2 ± 3.8 vs. 21.4 ± 11.9 days, p = 0.001). The upper mini-sternotomy group showed a lower postoperative red blood cell transfusion volume (4.6 ± 3.3 vs. 6.7 ± 5.7 units, p = 0.042) and postoperative drainage volume (764 ± 549 vs. 1255 ± 745 ml, p = 0.034). The rates of dialysis for newly occurring renal failure, neurological complications, and re-exploration were similar between the two groups (p = 1.000).

Conclusion
The upper mini-sternotomy approach is safe and beneficial in ascending aorta surgery with complex procedures for aortic dissection, including total arch replacement and aortic root repair.
Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study
Authors: Tang Rosalind , Howe Laura D. , Suderman Matthew , Relton Caroline L. , Crawford Andrew A. , Houtepen Lotte C. 
Published: April 2020

Abstract
Background
Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation-predicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, adverse mental and physical health, and elevated diurnal and baseline salivary cortisol. Childhood adversity is also associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which produces the neuroendocrine hormone cortisol. It remains unknown whether these associations are specific to certain types of adversity. Herein, we investigate the associations of ACEs with DNA methylation age acceleration and plasma cortisol in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.

Methods
In this study of the children in ALSPAC, we used multiple linear regression to examine associations of cumulative exposure to ACE, as well as exposure to ten individual types of ACEs, with Horvath-estimated DNA methylation age acceleration and with baseline plasma cortisol. The ten ACEs were those included in the World Health Organization’s ACE International Questionnaire. Data on ACEs were prospectively collected from age 0–14 years. DNA methylation age acceleration and plasma cortisol were measured at mean 17.1 years and 15.5 years, respectively.

Results
We included 974 UK children in the present study. Exposure to four or more ACEs compared to zero was associated with DNA methylation age acceleration in girls (β, 95% CI = 1.65, 0.25 to 3.04 years) but not in boys (β, 95% CI = − 0.11, − 1.48 to 1.26 years). Also, in girls, emotional abuse and physical abuse were each associated with DNA methylation age acceleration (β, 95% CI = 1.20, 0.15 to 2.26 years and β, 95% CI = 1.22, 0.06 to 2.38 years, respectively). No other ACEs were associated with accelerated DNA methylation age in either sex. Associations were also null between ACE and cortisol, and cortisol and DNA methylation age acceleration.

Conclusions
In this prospective population-based study of UK children, cumulative ACE exposure, emotional abuse, and physical abuse between age 0 and 14 years were each associated with Horvath-estimated DNA methylation age acceleration at age 17 years in girls but not in boys.
Ovarian status modulates cardiovascular autonomic control and oxidative stress in target organs
Authors: Ferreira Maycon Junior , Sanches Iris Callado , Jorge Luciana , Llesuy Susana Francisca , Irigoyen Maria Cláudia , De Angelis Kátia 
Published: April 2020

AbstractStudies have presented conflicting findings regarding the association between both fluctuation and deprivation of ovarian hormones and cardiovascular autonomic modulation and oxidative stress and their potential impact on resting arterial pressure (AP) and cardiovascular risk. This study aimed to assess cardiovascular autonomic modulation, baroreflex sensitivity (BRS), and oxidative stress in male rats (M) and in female rats during ovulatory (FOV) and non-ovulatory phases (FNOV) of the estrous cycle and after deprivation of ovarian hormones (FO). Direct AP was recorded, and BRS was assessed by using increasing doses of phenylephrine and sodium nitroprusside. AP and heart rate variability were assessed by spectral analysis. Oxidative stress profile was evaluated in cardiac, renal, and muscle tissues. In females, the ovulatory phase and ovarian hormone deprivation induced an increase in AP (FOV and FO ~ 9 mmHg) when compared to the non-ovulatory phase. Ovariectomy promoted increased cardiac sympathovagal balance (~ 17–37%) when compared to other groups. Both FOV and FO groups presented impaired BRS, associated with higher AP variability. In general, antioxidant capacity was higher in the FNOV than in the M group. Ovarian hormone deprivation induced a decrease in catalase activity in cardiac and renal tissues and an increase in lipid peroxidation in all tissues analyzed. Positive correlations (p < 0.05) were found between vascular sympathetic modulation and lipid peroxidation in cardiac (r = 0.60), renal (r = 0.60), and muscle (r = 0.57) tissues. In conclusion, both oscillation and deprivation of ovarian hormones play an important role in cardiovascular autonomic control and oxidative stress profile in target organs, which is reflected in AP changes.
Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)
Authors: Sakae Yuta , Oikawa Akira , Sugiura Yuki , Mita Masatoshi , Nakamura Shuhei , Nishimura Toshiya , Suematsu Makoto , Tanaka Minoru 
Published: April 2020

ABSTRACT
The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal. Metabolomic and RT-qPCR analyses indicated that pantothenate metabolism was suppressed by starvation. Consistently, inhibiting the pantothenate metabolic pathway caused sex reversal. The final metabolite in this pathway is coenzyme A, an essential factor for lipogenesis. Inhibiting fatty acid synthesis, the first step of lipogenesis, also caused sex reversal. The expression of dmrt1, a critical gene for male development, was suppressed by starvation, and a dmrt1 (Δ13) mutant did not show sex reversal under starvation. Collectively, these results indicate that fatty acid synthesis is involved in female-to-male sex reversal through ectopic expression of male gene dmrt1 under starvation.
“To Fly Under Borrowed Colours”: Insulin Discovery Accounts, Scientific Credit, and the Nobel Prize
Authors: Jorgensen-Earp Cheryl R. , Jorgensen Darwin D. 
Published: April 2020

Abstract
The struggle over credit for the discovery of insulin serves as one of the ugliest examples of the tensions and rivalries inherent in the growth of large-scale laboratory science. An understanding of this historic controversy also lends insight into the use of informal self-narratives directed to the scientifıc community in the negotiation of credit for discovery. Such informal accounts constitute a distinct form of argumentative address that is separate both from formal oral and written presentations of research, also aimed at a scientifıc audience, and popularized accounts aimed at a lay audience. In providing informal self-narratives to their scientifıc peers, the four insulin principals discussed in this article apparently shared a tacit understanding of the narrative grounds on which they could base their claims for discovery credit. In this study, we uncover widespread thematic similarities within these narratives, possibly indicating a common set of criteria within the scientifıc community for judging not only formal scientifıc proof but also the narrative proof found in informal discovery accounts.
Trauma and Its Ancient Literary Representation: Mark 5,1–20
Authors: Hogeterp Albert 
Published: April 2020

AbstractThis article revisits Mark 5,1–20 from the perspective of trauma theory, in light of historical contexts of Gerasa’s collective trauma and the cultural contexts of ancient perceptions of demons and their exorcism. The interplay between individual and collective levels of the story sheds light on symbolic overtones of an unresolved trauma about Roman military presence in the country of the Gerasenes. The story represents this trauma through literary indirection, including not only the enigmatic relation between “Legion” and the drowning swine, but also the paradoxical contrasts between individual and collective requests to Jesus. Mark 5,1–20 evokes meanings not only as pre-Markan tradition, but also as Markan redaction which intersect in crucial ways with the prelude to Jerusalem’s destruction (68–70 C.E.).
МЕТАМОДЕРНІСТСЬКІ ЗАСАДИ МЕДІАПСИХОЛОГІЇ ОСОБИСТОСТІ (англ)
Authors: Карпенко Зіновія 
Published: April 2020

У статті наведено приклад реалізації методологічних засад метамодернізму в науковий дискурс медіапсихології особистості. Оскільки метамодернізм передбачає ситуативно виправдане почергове використання об’єктивних, кількісних, пояснювальних методів і суб’єктивних, якісних, описових методів, то обґрунтовується необхідність комплексних міждисциплінарних досліджень у царині медіапсихології загалом та медіавпливу зокрема із застосуванням методологічної тріангуляції, що використовує змішані методи – як експериментально-діагностичні із широким залученням математико-статистичних методів, так і герменевтичний метод, зокрема наративний аналіз. Насамперед здійснено перевірку статистичної значущості міжпоколінних та гендерних відмінностей між діагностованими змінними і зроблено висновок про універсальну й об’єктивну вікову і соціокультурну детермінацію цих відмінностей, а не їх тотальну зумовленість матеріальним становищем, політичною і правовою самосвідомістю громадян. Поєднання обох груп методів, що стосуються організації та медіації конфліктної взаємодії учасників політичного ток-шоу, дало змогу виявити хибні інтерпретації статистичного матеріалу, представлені в книжці С. Шустера «Свобода слова проти страху і приниження…», зумовлені браком професійно-психологічної компетентності автора, а також експлікувати провідні теми, смисли, рольові позиції, архетипні патерни поведінки учасників телепередачі. Подано аксіопсихологічну реінтерпретацію переживання масових емоцій Д. Муазі з позицій принципу інтегральної суб’єктності, висунутого З. Карпенко. Акцентовано на ролі ведучого як наратора, відповідального за режисуру телепередачі, та фасилітатора конфліктної взаємодії в негативному чи позитивному векторі.
Fabrication and Characterization of Gas Sensor from ZrO2: MgO Nanostructure Thin Films by R.F. Magnetron Sputtering Technique
Authors: Et al. Khalil 
Published: April 2020

Thin films ZrO2: MgO nanostructure have been synthesized by a radio frequency magnetron plasma sputtering technique at different ratios of MgO (0,6, 8 and 10)% percentage to be used as the gas sensor for nitrogen dioxide NO2. The samples were investigated by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) and sensing properties were also investigated. The average particle size of all prepared samples was found lower than 33.22nm and the structure was a monoclinic phase. The distribution of grain size was found lower than36.3 nm and uninformed particles on the surface. Finally, the data of sensing properties have been discussed, where they indicated that sensitivity reached 42.566% at 300 oC, spectral response time less than 52.2 s and recovery time 135.9 s.
Assessment of service satisfaction and associated status among women who have given birth in Adigrat general hospital, Ethiopia, 2018.
Authors: Gebremeskel Teferi Gebru , Tukue Desta , Gebremariam Lemlem , Teame Hirut 
Published: April 2020

Abstract
Background: The study aimed to assess the satisfaction of service delivery and the associated status among women who gave birth to Adigrat general hospital, Ethiopia, 2018. Methods: Institutional based cross-sectional study design was conducted in Adigrat hospital from February to March 2018. Interviews with interviewed using structured questionnaires of 302 systematic women who were born at general hospital. The information is submitted to EPI-info version 7.2 and exported to SPSS version 20 for analysis. Summary statistics and logistic regression analyses were performed. OR with two-sided 95% CI and P-value<0.05 were used to identify the factors associated with the service satisfaction. Result: Maternal satisfaction in labor and delivery was70.2%. Women living in rural areas were 98.8% times less likely to be satisfied with service delivery than those living in urban area (AOR: 0.012, 95%CI (0.002, 0.065). women who plan to give birth at the hospital have more than forty times more than their referrals for maternity service (AOR: 40.43, 95%CI (2.75, 595.23)).Conclusion: The overall share of mothers who were satisfied with the service they provided was appropriate. As a city resident and the reason for delivering in the hospital are related to service satisfaction. Therefore the staff of the hospital has a continuing education and personal relationship. The care giver must fully understand the value of their care and provided care that is in line with those expectations.
The Association between Dietary Diversity Score and Somatoform Complaints Profile among Iranian Adults
Authors: Keshteli Ammar Hassanzadeh , Mohammadi Hamed , Yahay Maryam , Haghighatdoost Fahimeh , Esmaillzadeh Ahmad , Roohafza Hamidreza , Afshar Hamid , Feizi Awat , Adibi Peyman 
Published: April 2020

Abstract
Background: The present study aimed to investigate the association between dietary diversity score (DDS) and somatoform complaints profile.Methods: The current cross-sectional study was conducted on 2818 adults aged 19-65 years working in Isfahan province, Iran. A Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ) was used to collect dietary intake of participants. Somatoform symptoms were assessed using a validated comprehensive 31-items questionnaire.Results: After adjusting for the impacts of various confounders it was revealed that lower DDS is associated with higher risk of experiencing greater scores of psychological (OR=1.44, 95% CI: 1.06, 1.95; P=0.029) and pharyngeal-respiratory (OR=1.54, 95% CI: 1.17, 2.04; P=0.009) somatoform complaints. No significant association was found between DDS and neuro-skeletal and gastrointestinal somatoform complaints. In addition, stratified analysis by sex indicated that the lower DDS increased the risk of higher scores of psychological (OR = 1.73, 95% CI = 1.17, 2.56; P = 0.02) and pharyngeal-respiratory (OR = 1.75, 95% CI = 1.22, 2.49, P = 0.007) somatic complaints in women, but not in men.Conclusion: Present study indicated that the lower DDS is associated with higher risk of psychological and pharyngeal-respiratory somatoform complaints. Future prospective studies and particularly clinical trials are warranted to confirm these findings.