bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luminosity calculation of meteor entry based on detailed flow simulations in the continuum regime
Authors: Dias B. , Scoggins J. B. , Magin T. E. 
Published: February 2020

Context. Composition, mass, and trajectory parameters of meteors can be derived by combining observations with the meteor physics equations. The fidelity of these equations, which rely on heuristic coefficients, significantly affects the accuracy of the properties inferred.
Aims. Our objective is to present a methodology that can be used to compute the luminosity of meteor entry based on detailed flow simulations in the continuum regime.
Methods. The methodology consists in solving the Navier–Stokes equations using state-of-the-art physico-chemical models for hypersonic flows. It includes accurate boundary conditions to simulate the surface evaporation of the molten material and coupled flow-radiation effects. Such detailed simulations allow for the calculation of heat-transfer coefficients and luminous efficiency, which can be incorporated into the meteor physics equations. Finally, we integrate the radiative transfer equation over a line of sight from the ground to the meteor to derive the luminosity magnitude.
Results. We use the developed methodology to simulate the Lost City bolide and to derive the luminosity magnitude, obtaining good agreement between numerical results and observations. The computed color index is more prominent than the observations. This is attributed to a lack of refractory elements such as Ca in the modeled flow that might originate from the vaporization of droplets in the trail, a phenomenon currently not included in the model.
QS ENDO Real – A Study by the German Endometriosis Research Foundation (SEF) on the Reality of Care for Patients with Endometriosis in Germany, Austria and Switzerland
Authors: Zeppernick Felix , Zeppernick Magdalena , Janschek Elisabeth , Wölfler Monika , Bornemann Sebastian , Holtmann Laura , Oehmke Frank , Brandes Iris , Scheible Chi Mi , Salehin Darius , Pethick Sigrid Vingerhagen , Boosz Alexander Stephan , Krämer Bernhard , Sillem Martin , Bühler Klaus , Keckstein Jörg , Schweppe Karl Werner , Meinhold-Heerlein Ivo ,   for the QS Endo Working Group of the Endometriosis Research Foundation (SEF)
Published: February 2020

AbstractEndometriosis affects a significant number of young premenopausal women. Quite apart from the medical challenges, endometriosis is a relevant burden for healthcare and social security systems. Standardized quality indicators for the treatment of endometriosis have not previously been systematically verified. The three-stage study QS ENDO was initiated to record and improve the reality and quality of care. One of its aims is to create quality indicators for the diagnosis and treatment of endometriosis. For the first stage of QS ENDO Real, letters were sent to all 1014 gynecological departments in the German-speaking area of Europe (the DACH region) which included a questionnaire as a means of surveying the current state of care. A total of 296 (29.2%) of the centers which received the questionnaire participated in the survey. The subsequent evaluation of the completed questionnaires showed that the majority of patients with endometriosis (around 60%, based on estimates from the data) are not treated in hospitals which have been certified by the SEF. The guidelines recommend the use of specific classification systems (rASRM, ENZIAN) but, depending on the level of care offered by the hospital, only around 44.4 to 66.4% of departments used the rASRM score and only 27% of hospitals used the ENZIAN classification system to describe deep-infiltrating endometriosis. When taking patientsʼ medical history, some centers (6.6 – 17.9%) considered questions about leading symptoms such as dyschezia, dysuria and dyspareunia to be unimportant. QS ENDO Real has made it possible, for the first time, to get an overview of the reality of care provided to patients with endometriosis in the German-speaking areas of Europe. The findings indicate that several of the measures recommended in international guidelines as the gold standard of care are only used to treat some of the patients. In this respect, more efforts will be needed to provide more advanced training. The approach used for treatment must be guideline-based, also in not-certified centers, to improve the quality of care in the treatment of patients with endometriosis.
An Economic Analysis of Aneuploidy Screening of Oocytes in Assisted Reproduction in Germany
Authors: Neumann Kay , Griesinger Georg 
Published: February 2020

Abstract
Background The randomized ESTEEM trial reported that preimplantation genetic aneuploidy testing of oocytes by polar body biopsy (PGT-A) with array comparative genomic hybridization (aCGH) in women aged 36 – 40 years undergoing assisted reproduction treatment reduces the number of embryo transfers and the risk of miscarriage while not impacting the live birth rate.
Method A decision tree model based on data from the ESTEEM trial was created and analyzed, using three cost scenarios for assisted reproduction treatment in Germany (statutory health insurance [GKV] = the deductible is 50% of the standard medical costs; private medical insurance [PKV] = invoicing is based on the German medical fee schedule [GOÄ]; private medical insurance with a simple GOÄ factor [simple GOÄ factor] = invoicing is based on the standard medical fees multiplied by a linear GOÄ factor). The scenarios were compared for cost-effectiveness (cost per live birth), cost per prevented miscarriage and the threshold values for cost and effectiveness.
Results PGT-A increased the costs per live birth in all scenarios (GKV: + 208%; PKV: + 49%; simple GOÄ factor: + 89%). A threshold analysis showed a substantial cost discrepancy between the actual cost of the intervention based on GOÄ (€ 5801) vs. the theoretically tolerable PGT-A cost (GKV: € 561, PKV: € 1037, single GOÄ-factor: € 743). The incremental cost per one prevented miscarriage was approximately € 70 000 – 75 000 for all cost scenarios.
Conclusion The use of PGT-A with aCGH in assisted reproduction cannot be recommended from a cost-effectiveness perspective.
Campaign funding laws and the political economy of money politics in Nigeria
Authors: Okeke G. S. Mmaduabuchi , Nwali Uche 
Published: February 2020

ABSTRACT
Campaign funding laws have failed to stem the phenomenon of money politics in postcolonial Nigeria. The predominant narrative in extant literature attributes this failure to lack of enforcement of the laws. This article rethinks the lack of enforcement narrative and argues that the laws have inbuilt biases that legitimise and perpetuate money politics; hence, any investment in enforcement can only yield meagre returns. But beyond the biased legal regime, mass poverty is largely why attempts to remedy the challenge of money politics via the instrument of law have failed. The article recommends a recalibration of Nigeria’s political economy to usher in a resource allocation and wealth redistribution regime that ensures the citizenry are not so poor that they would be vulnerable to material inducement.
Quantitative measurements of oxygen atom and negative ion densities in a low pressure oxygen plasma by cavity ringdown spectroscopy
Authors: Peverall Robert , Rogers Samuel D A , Ritchie Grant A D 
Published: February 2020

Abstract
In this paper we report measurements of the absolute concentration of ground state oxygen atoms produced in a low pressure (≤100 mTorr) inductively coupled oxygen plasma. These experiments have utilised cavity ringdown spectroscopy, allowing line of sight absorption to be measured on the optically forbidden 1D ← 3P transition around 630 nm. Both the translational temperature and the absolute concentrations of the two most populated spin–orbit levels (J = 1 and 2) have been determined as a function of plasma pressure at a fixed operating power of 300 W, allowing accurate determination of dissociation fraction; in all cases, the dissociation fraction is considerable, ≥10%, maximising at 15% for 20 mTorr. Time-resolved measurements of the rate of loss of the oxygen atoms when the plasma is extinguished have allowed the probability for wall-loss in the plasma chamber, γ, to be determined; in this case, for an aluminium surface, γ is determined to be ca. a few ×10−3, with the exact value depending on pressure. In addition, the O− number density is shown to be an inverse function of pressure, showing a maximum of 1.6 × 1010 cm−3 at 10 mTorr, falling to 2 × 109 cm−3 at 100 mTorr, and characteristic of a discharge operating in the detachment regime. The measured number densities are interpreted using calculated electron energy distribution functions and yield physically reasonable values for the electron number density.
Untangling cryptic diversity in the High Andes: Revision of the Scytalopus [magellanicus] complex (Rhinocryptidae) in Peru reveals three new species
Authors: Krabbe Niels K , Schulenberg Thomas S , Hosner Peter A , Rosenberg Kenneth V , Davis Tristan J , Rosenberg Gary H , Lane Daniel F , Andersen Michael J , Robbins Mark B , Cadena Carlos Daniel , Valqui Thomas , Salter Jessie F , Spencer Andrew J , Angulo Fernando , Fjeldså Jon 
Published: February 2020

AbstractTropical mountains feature marked species turnover along elevational gradients and across complex topography, resulting in great concentrations of avian biodiversity. In these landscapes, particularly among morphologically conserved and difficult to observe avian groups, species limits still require clarification. One such lineage is Scytalopus tapaculos, which are among the morphologically most conserved birds. Attention to their distinctive vocal repertoires and phylogenetic relationships has resulted in a proliferation of newly identified species, many of which are restricted range endemics. Here, we present a revised taxonomy and identify species limits among high-elevation populations of Scytalopus tapaculos inhabiting the Peruvian Andes. We employ an integrated framework using a combination of vocal information, mitochondrial DNA sequences, and appearance, gathered from our own fieldwork over the past 40 yr and supplemented with community-shared birdsong archives and museum specimens. We describe 3 new species endemic to Peru. Within all 3 of these species there is genetic differentiation, which in 2 species is mirrored by subtle geographic plumage and vocal variation. In a fourth species, Scytalopus schulenbergi, we document deep genetic divergence and plumage differences despite overall vocal similarity. We further propose that an extralimital taxon, Scytalopus opacus androstictus, be elevated to species rank, based on a diagnostic vocal character. Our results demonstrate that basic exploration and descriptive work using diverse data sources continues to identify new species of birds, particularly in tropical environs.
The role of scratching in the control of ectoparasites on birds
Authors: Goodman Graham B , Klingensmith Margaux C , Bush Sarah E , Clayton Dale H 
Published: February 2020

AbstractGrooming by birds is thought to serve essential anti-parasite functions. While preening has been well studied, little is known about the function of scratching in birds. We conducted a series of experiments to determine the effectiveness of scratching for controlling feather lice (Columbicola columbae) on Rock Pigeons (Columba livia). First, we used a hobbling technique to impair scratching. After 6 mo, hobbled birds had significantly more lice than controls that could scratch. In addition, lice on hobbled birds were concentrated on the birds’ heads and necks (i.e. the regions that birds scratch). Secondly, we tested the role the claw plays in scratching by declawing nestlings. Once mature, declawed pigeons had significantly more lice than control birds with claws. Moreover, lice on declawed birds were concentrated on the head and neck. Next, we tested whether the flange found on the middle claw of many bird species enhances scratching. We experimentally manipulated the flange; however, the number and location of lice on birds without flanges was not significantly different than that on control birds with intact flanges. Finally, we tested whether scratching removes parasites directly or indirectly by “flushing” them onto body regions where they can be preened. When we impaired scratching (with hobbles) and preening (with “bits”) we found that scratching no longer reduced the number of lice on birds. Our results indicated that scratching and preening work synergistically; scratching reduces parasite load by flushing lice onto regions of the body where they can be eliminated by preening.
Rhapsody: predicting the pathogenicity of human missense variants
Authors: Ponzoni Luca , Peñaherrera Daniel A , Oltvai Zoltán N , Bahar Ivet 
Published: February 2020

Abstract

Motivation
The biological effects of human missense variants have been studied experimentally for decades but predicting their effects in clinical molecular diagnostics remains challenging. Available computational tools are usually based on the analysis of sequence conservation and structural properties of the mutant protein. We recently introduced a new machine learning method that demonstrated for the first time the significance of protein dynamics in determining the pathogenicity of missense variants.

Results
Here, we present a new interface (Rhapsody) that enables fully automated assessment of pathogenicity, incorporating both sequence coevolution data and structure- and dynamics-based features. Benchmarked against a dataset of about 20 000 annotated variants, the methodology is shown to outperform well-established and/or advanced prediction tools. We illustrate the utility of Rhapsody by in silico saturation mutagenesis studies of human H-Ras, phosphatase and tensin homolog and thiopurine S-methyltransferase.

Availability and implementation
The new tool is available both as an online webserver at http://rhapsody.csb.pitt.edu and as an open-source Python package (GitHub repository: https://github.com/prody/rhapsody; PyPI package installation: pip install prody-rhapsody). Links to additional resources, tutorials and package documentation are provided in the 'Python package' section of the website.

Supplementary information
Supplementary data are available at Bioinformatics online.
A nonparametric approach to high-dimensional k-sample comparison problems
Authors: Mukhopadhyay Subhadeep , Wang Kaijun 
Published: February 2020

Summary
High-dimensional $k$-sample comparison is a common task in applications. We construct a class of easy-to-implement distribution-free tests based on new nonparametric tools and unexplored connections with spectral graph theory. The test is shown to have various desirable properties and a characteristic exploratory flavour that has practical consequences for statistical modelling. Numerical examples show that the proposed method works surprisingly well across a broad range of realistic situations.
Basal Takotsubo syndrome with transient severe mitral regurgitation caused by drug use: a case report
Authors: Albenque Grégoire , Bohbot Yohann , Delpierre Quentin , Tribouilloy Christophe 
Published: February 2020

Abstract

Background
Takotsubo syndrome (TTS) is a reversible cardiomyopathy. Little is known regarding its basal form and possible complications.

Case summary
A 31-year-old woman with no medical history was hospitalized for attempted suicide by ingestion of cocaine, benzodiazepine, and methadone. Initially, the patient received intensive care for coma and bradypnoea. After naloxone administration, the neurological situation improved, but the patient developed acute pulmonary oedema. Transthoracic echocardiography (TTE) revealed left ventricular systolic dysfunction with the basal wall’s akinesia associated with moderate to severe restrictive mitral regurgitation. Global longitudinal strain (GLS) was impaired mainly in the basal segments. A coronary computed tomography ruled out coronary artery disease. Symptoms improved quickly under diuretic treatment. Transthoracic echocardiography at Day 6 showed improved basal wall contraction, with a left ventricular ejection fraction (LVEF) of 50% and moderate mitral regurgitation. TTE at Day 30 confirmed the diagnosis of myocardial infarction with non-obstructive coronary arteries related to a basal TTS after complete recovery of the LVEF, normalization of the wall motion and GLS, and the absence of residual mitral regurgitation.

Discussion
We report a case of acute pulmonary oedema due to basal TTS complicated by severe transient mitral regurgitation associated with moderate left ventricular dysfunction. Measuring strain by speckle-tracking can be useful to diagnose and monitor this entity. The use of coronary computed tomography is informative in young patients to rule-out coronary artery disease.
Rescue aortic balloon valvuloplasty during procedural cardiac arrest while treating critical left main stem stenosis: a case report
Authors: Benenati Stefano , Scarsini Roberto , De Maria Giovanni Luigi , Banning Adrian P 
Published: February 2020

Abstract

Background
Best timing for coronary revascularization in patients with severe aortic stenosis (AS) who was a candidate for transcatheter aortic valve implantation (TAVI) is still matter of debate.

Case summary
We here report the case of an 87-year-old man with severe AS presenting with non-ST-segment elevation myocardial infarction. Coronary angiography revealed a highly complex and calcific left main stem (LMS) lesion. Rotablation-assisted percutaneous coronary intervention (PCI) was attempted but was complicated by post-stenting rapidly evolving haemodynamic impairment. A rescue ‘pacing-free’ balloon aortic valvuloplasty (BAV) was performed to rescue the patients, allowing prompt restoration of cardiac output and coronary perfusion.

Discussion
According to guidelines and preliminary evidence, decision should be performed case by case and based on the degree of severity and complexity of either AS or coronary disease. The strategy of treating coronary lesions first may limit the risk of potential ischaemic complications during TAVI. However, the downside of it is the risk of hemodynamic crash with potential catastrophic evolution in case of PCI complications in presence of severe AS. A ‘bailout BAV’ can be considered as a salvage-strategy in case of complex and complicated LMS-PCI in the context of severe AS and advanced status of haemodynamic impairment. This approach must be seen as very last resort, while appropriate pre-procedural planning is still highly recommended in order to prevent potentially fatal procedural complications in this fragile clinical setting.
Infective endocarditis of an asymptomatic congenital aorta-right atrial tunnel: a case report
Authors: Onorato Eustaquio Maria , Costante Anna Maria , Andreini Daniele , Bartorelli Antonio L 
Published: February 2020

Abstract

Background
Aorta-right atrial tunnel (ARAT) is a rare congenital anomaly whose aetiology and incidence are unknown. It might represent a diagnostic and therapeutic challenge requiring a combination of imaging modalities and an integrated teamwork.

Case summary
We report a case of a 23-year-old man with an asymptomatic ARAT complicated by infective endocarditis, diagnosed with non-invasive multimodality imaging, and successfully treated with a catheter-based approach.

Discussion
Aorta-right atrial tunnel closure in asymptomatic patients is still a matter of debate. Considering the risk of serious complications surgical treatment might be recommended soon after diagnosis. In selected cases, catheter-based closure might represent a safe, effective, and less invasive alternative to traditional surgical approach.
The African Slave Trade and Modern Household Finance
Authors: Levine Ross , Lin Chen , Xie Wensi 
Published: February 2020

AbstractWe evaluate the impact of the African slave trade between 1400 and 1900 on modern household finance. Exploiting cross-country and cross-ethnic group differences in the intensity with which people were enslaved and exported from Africa, we find that slave exports during the 1400–1900 period are negatively associated with current measures of household (a) access to financial services, (b) access to credit, (c) use of mobile finance and (d) trust in financial institutions, suggesting that the slave trade has had an enduring, deleterious effect on household finance.
Seed Adaptive Traits of Fagus sylvatica Populations in Northeastern Greece
Authors: Varsamis Georgios , Merou Theodora , Takos Ioannis , Malesios Chrisovalantis , Manolis Apostolos , Papageorgiou Aristotelis C 
Published: February 2020

Abstract
Fagus sylvatica in Europe is expected to be severely affected by the ongoing climate change. In this article, seed adaptive traits, in terms of morphology and germination, of F. sylvatica populations of different postglacial lineage and intrapopulation genetic diversity were evaluated. Eight plots from two geographical provenances, Evros and Drama, were selected. Provenance shaped both morphology and germination patterns, but the effect was more pronounced on germination. Seeds from Drama were larger and heavier than those from Evros but exhibited a higher degree of dormancy and slower germination. High among-plots variability on morphology and germination was also observed, especially in Evros. This higher variability was consistent with the higher level of genetic diversity observed at genomic and chloroplast DNA markers at small or larger spatial scales from previous published studies on the same plots. Results suggested the existence of different seed adaptation strategies, mainly between provenances, as a result of possible adaptation to different environmental conditions, whereas a possible influence of a generally complex pattern of admixture between different beech subspecies and postglacial lineages could not be excluded.
The Incidence and Prevalence of Human Papilloma Virus–associated Cancers in IBD
Authors: Segal Jonathan P , Askari Alan , Clark Susan K , Hart Ailsa L , Faiz Omar D 
Published: February 2020

Abstract

Aim
The human papilloma virus has been associated with anal, cervical, vaginal, and penile cancers. The primary aim of this population-based study is to determine whether HPV-associated cancers are more commonplace in patients with inflammatory bowel disease (IBD).

Method
The Hospital Episode Statistics (HES) database from 1997 to 2012, linked with officer for age standardized rates (ASR), were calculated using population data, and Cox regression analysis was used to determine whether IBD patients have poorer survival compared with non-IBD patients.

Results
A total of 61,648 patients were included in this study; of these, 837 patients had a preexisting diagnosis of IBD (1.4%). Inflammatory bowel disease patients had a significantly higher ASR of anal cancers than the non-IBD population: 5.5 per 100,000 in the IBD group compared with 1.8 in the non-IBD group. The IBD group was also diagnosed with anal cancers at a younger age (60 years compared with 66 years in the non-IBD group, P &lt; 0.001). The survival of IBD patients with anal cancer was also poorer than the non-IBD group (hazard ratio, 1.32; 95% confidence interval, 1.15–1.52; P &lt; 0.001). On average, survival was significantly shorter in the IBD group with anal cancer (46 months) compared with the non-IBD group (61 months, P &lt; 0.001). Age standardized rates for cervical cancer was significantly higher in the IBD group (5.2 of 100,000) compared with the non-IBD group (4.6 of 100,000 P = 0.042).

Conclusion
Patients with IBD have a higher rate of anal cancer compared with the general population. Survival is also worse for anal cancers in the IBD group.