bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of electron‐beam irradiation on inoculated Listeria innocua, microbiological and physicochemical quality of fresh noodles during refrigerated storage
Authors: Shi Feifei , Zhao Hongwei , Song Hongbo , Guo Weiling , Wang Li , Cui Xiaorui , Zhang Weidong , Li Shurong 
Published: December 2019

AbstractAs a nonthermal sterilization technology, electron‐beam irradiation (EBI) has attracted great interests for microbial inactivation in food preservation. In this study, the inactivation of inoculated Listeria innocua, natural microbiota, and quality of fresh noodles treated by EBI during refrigerated storage were evaluated. Results showed that the initial L. innocua population (6.38 log CFU/g) was significantly reduced to an undetectable level by treatment with 3.0 kGy EBI. Moreover, treatment with 3 kGy EBI significantly reduced the initial total bacteria counts and fungal counts (mold and yeast) from 5.66 and 3.15 log CFU/g to 2.90 and 2.11 log CFU/g, respectively. However, along with the storage process, the inoculated L. innocua and natural microbiota were recovered resulting in the increased populations of the spoilage microorganisms. Increasing the dose of EBI to 4.0 kGy or 5.0 kGy, the L. innocua population was inhibited to the undetectable level and the microbiological quality of the fresh noodles was kept in the acceptable level during the 28 day storage. In addition, changes of the physicochemical indicators including pH value, color, cooking characteristics, texture, and sensory of fresh noodles treated with EBI were delayed during storage. These results reveal that EBI treatment can improve the microbiological safety and shelf life of fresh noodles without impairing quality.
Functional approach and agro‐climatic information to improve the estimation of olive oil fatty acid content from near‐infrared data
Authors: Sánchez‐Rodríguez María Isabel , Sánchez‐López Elena M. , Marinas Alberto , Urbano Francisco José , Caridad José M. 
Published: December 2019

AbstractExtra virgin olive oil (EVOO) is very appreciated by its taste, flavor, and benefits for health, and so, it has a high price of commercialization. This fact makes it necessary to provide reliable and cost‐effective analytical procedures, such as near‐infrared (NIR) spectroscopy, to analyze its traceability and purity, in combination with chemometrics. Fatty acids profile of EVOO, considered as a quality parameter, is estimated, firstly, from NIR data and, secondly, by adding agro‐climatic information. NIR and agro‐climatic data sets are summarized by using principal component analysis (PCA) and treated by both scalar and functional approaches. The corresponding PCA and FPCA are progressively introduced in regression models, whose goodness of fit is evaluated by the dimensionless root‐mean‐square error. In general, SFAs, MUFAs, and PUFAs (and disaggregated fatty acids) estimations are improved by adding agro‐climatic besides NIR information (mainly, temperature or evapotranspiration) and considering a functional point of view for both NIR and agro‐climatic data.
Maturation of Lipophagic Organelles in Hepatocytes Is Dependent Upon a Rab10/Dynamin‐2 Complex
Authors: Li Zhipeng , Weller Shaun G. , Drizyte‐Miller Kristina , Chen Jing , Krueger Eugene W. , Mehall Bridget , Stöckli Jacqueline , Casey Carol A. , Cao Hong , McNiven Mark A. 
Published: December 2019

Background and Aims
Hepatocytes play a central role in storage and utilization of fat by the liver. Selective breakdown of lipid droplets (LDs) by autophagy (also called lipophagy) is a key process utilized to catabolize these lipids as an energy source. How the autophagic machinery is selectively targeted to LDs, where it mediates membrane engulfment and subsequent degradation, is unclear. Recently, we have reported that two distinct GTPases, the mechanoenzyme, dynamin2 (Dyn2), and the small regulatory Rab GTPase, Rab10, work independently at distinct steps of lipophagy in hepatocytes.

Approach and Results
In an attempt to understand how these proteins are regulated and recruited to autophagic organelles, we performed a nonbiased biochemical screen for Dyn2‐binding partners and found that Dyn2 actually binds Rab10 directly through a defined effector domain of Rab10 and the middle domain of Dyn2. These two GTPases can be observed to interact transiently on membrane tubules in hepatoma cells and along LD‐centric autophagic membranes. Most important, we found that a targeted disruption of this interaction leads to an inability of cells to trim tubulated cytoplasmic membranes, some of which extend from lipophagic organelles, resulting in LD accumulation.

Conclusions
This study identifies a functional, and direct, interaction between Dyn2 and a regulatory Rab GTPase that may play an important role in hepatocellular metabolism.
The influence of HR practices upon knowledge brokering in professional organizations for service improvement: Addressing professional legitimacy and identity in health care
Authors: Currie Graeme , Spyridonidis Dimitrios , Oborn Eivor 
Published: December 2019

AbstractDrawing upon sociology of professions, our study extends insight into the specific HR practices that shape the microdynamics of knowledge‐sharing behaviors among professionals. Empirically, we examine the influence of Human Resource (HR) practices on enactment of a knowledge‐brokering role by doctors to drive service improvement in health care. Our study shows, first, HR practices influence professional identity, which is predicated on jurisdictional autonomy and client interest. Second, HR practices influence the legitimacy of any role and associated activities, with professionals valuing collegial leadership and evidence‐based practice. Our study highlights it is employee perceptions of the effect of HR practices upon their legitimacy and identity that shape their attitudes and behavior toward knowledge sharing. Thus, different HR practices have different effects on knowledge sharing. Further, the same HR practice may be perceived differently even within the same cadre of professionals, depending upon their relative status and career interests.
The effects of the modified mosaic approach method on regional simulations of surface meteorological variables in western China
Authors: Chen Guangyu , Wei Zhigang , Jin Xiaoai , Dong Wenjie , Zhu Xian , Liu Yajing , Zheng Zhiyuan , Liu Yujia 
Published: December 2019

AbstractIn this article, a modified mosaic approach method (MMAM), which considers the subgrid‐scale effect of topographical height on atmospheric forcing, is introduced. Two experiments are designed to study the effects of MMAM on surface meteorological variables in Western China within the weather research and forecasting (WRF) modelling framework during June to August 2010. Results show that MMAM has obvious effects on surface 2 m temperature improvement. Simulations of the surface 2 m temperature with MMAM are closer to the observed values over a wide range of areas, particularly around the Qinghai‐Tibet Plateau and the Tianshan Mountains. However, MMAM does not show obvious improvements on 2 m relative humidity and on 10 m wind velocity. By investigations of two selected grid cells, we find that MMAM always shows a consistent deviation (positive or negative) on 2 m temperatures compared with the control experiment throughout the study period, which is related to the fact that the difference in topographical height within the model grid does not vary with time; the differences of surface energy illustrate that MMAM directly affects the upward longwave radiation due to a revision of the forcing temperature, resulting in a redistribution of surface energy.
Hydrological processes interconnecting the two largest watersheds of South America from multi‐decadal to inter‐annual time scales: A critical review
Authors: Zanin Paulo Rodrigo , Satyamurty Prakki 
Published: December 2019

AbstractThe hydrological aspects of the Amazon and the La Plata basins are interconnected through southward moisture transport performed by the Low‐Level Jet east of the Andes and the South Atlantic Convergence Zone. Remote effects of sea surface temperature variability in the Pacific and the Atlantic are of varied periodicities, from multi‐decadal to inter‐annual time scales. Major oscillations thus far detected are Atlantic Multi‐decadal Oscillation, Pacific Multi‐decadal Oscillation, North Atlantic Oscillation, Atlantic Dipole, Antarctic Oscillation, and the El Niño Southern Oscillation. In the multi‐decadal, inter‐decadal and decadal time scales, the effects of climate variability over the hydrological processes that interconnect the Amazon and La Plata watersheds are felt predominantly in the South American Monsoon season, while on the inter‐annual scale the effects vary along the year. The hydrological memory in Amazonian soils is also responsible for the inter‐annual variability of hydrology of the Amazon Basin. Due to the effects of soil water on evapotranspiration, the hydrological memory can affect the supply of moisture to the La Plata Basin, influencing the inter‐annual variability of this basin. The implications of the observed oscillations to the hydrological and climatological variability in the two basins are discussed and synthesized in this article. Hypotheses for future research are formulated.
Raman spectroscopy study of graphene formed by “in situ” chemical interaction of an organic precursor with a molten aluminium matrix
Authors: Yolshina L.A. , Vovkotrub E.G. , Shatunova A.A. , Pryakhina V.I. 
Published: December 2019

AbstractA study of graphene “in situ” formed during the chemical interaction of glucose with molten aluminium under a layer of molten alkaline halides in air at temperatures of 750–850°C is presented. By means of Raman and X‐ray photoelectron spectroscopy and electron microscopy, it is shown that graphene films synthesize in the aluminium. The number and defectiveness of graphene layers inside aluminium matrix depends on synthesis temperature– at 750°C two‐layer graphene and at 850°C three‐layer graphene form. The most defective graphene films synthesized at 750°C with the formation of five‐ and seven‐membered rings in plane of the graphene grid; the number of defects of graphene films is less for composite obtained at higher temperature. The evaluated defectiveness of graphene not exceed 14%; it evidences the formation of perfect graphene in aluminium matrix. The compressive stress value is the smallest for the sample obtained at 750°C and increases with temperature and plastic deformation because of differences in the crystal lattice parameters and their thermal expansion coefficients of aluminium and graphene. This fact explains the relation of defects number in graphene with temperature and plastic deformation. No aluminium carbide and graphene oxide were formed during synthesis inside aluminium matrix because of formation of defect‐free perfect graphene with high chemical stability. The absence of aluminium carbide was proven by means Raman spectroscopy, X‐ray photoelectron, transmission electron microscopy, and corrosion test with distilled water. It allows to propose aluminium‐graphene composites for numerous practical applications as a constructive material.
Stage and disease‐free interval help select patients for surgical management of locally recurrent and metastatic adrenocortical carcinoma
Authors: Lo Winifred , Ayabe Reed I. , Kariya Christine M. , Good Meghan L. , Steinberg Seth M. , Davis Jeremy L. , Ripley Robert T. , Hernandez Jonathan M. 
Published: December 2019

AbstractBackground and ObjectivesChemotherapeutic options for patients with recurrent/metastatic adrenocortical carcinoma (ACC) are limited, leading to consideration for surgical management. We sought to determine characteristics associated with an unequivocal survival benefit amongst patients undergoing re‐resection or metastasectomy.MethodsPatients who underwent surgery for recurrent/metastatic ACC were identified and stratified into two groups: those with postoperative survival comparable with what has been reported with chemotherapy alone (<12 months) and those surviving twice that duration (>24 months). Those who survived between 12 and 24 months were excluded, as the objective was to characterize patients who most distinctly benefited from resection. Clinicopathologic and treatment variables were evaluated for associations with survival.ResultsForty‐three patients survived more than 24 months and 15 patients died less than 12 months after reoperation. Tumor stage (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.45‐0.96) and disease‐free interval (DFI; OR, 3.23; 95% CI, 1.68‐6.22) were associated with prolonged survival. Tumor size, hormonal status, resection margin, and treatment with chemotherapy, radiation, and mitotane were not associated with prolonged survival. Patients who survived more than 24 months underwent more procedures for subsequent recurrences (median 4 vs 2; P < .001).ConclusionStage and DFI can help select optimal candidates for resection of recurrent/metastatic ACC. Patients selected for surgical management should be informed of the likelihood of requiring multiple interventions.
Inhibitory Effects of Glucosylceramide on Tumorigenesis Induced by a Carcinogen in Mice
Authors: Fujiwara Kazunori , Yazama Hiroaki , Donishi Ryouhei , Koyama Satoshi , Fukuhara Takahiro , Takeuchi Hiromi 
Published: December 2019

ObjectiveGlucosylceramide (Glu‐Cer), a glycosylated form of ceramide, has been reported to have cytotoxic effects in the cells of various cancers. We previously reported that dietary Glu‐Cer from rice bran had inhibitory effects on human head and neck squamous cell carcinoma (HNSCC) in nonobese diabetes (NOD)/severe combined immunodeficiency (SCID) mice. In HNSCC, preventing recurrence and second primary cancer is required to improve prognosis. The purpose of the present study was to determine whether dietary Glu‐Cer had anticarcinogenic and antitumorigenic effects in a mouse model of HNSCC.MethodsA total of 40 CB6F1‐Tg rasH2@Jcl mice were divided into two groups: control and Glu‐Cer. All mice were given 4‐nitroquinoline 1‐oxide for 24 weeks. Control group mice were fed the normal diet without Glu‐Cer. The Glu‐Cer group mice were given a mixture of the normal diet plus 0.25% Glu‐Cer for 24 weeks. Microscopic examination was performed to identify grossly visible preneoplasms and neoplasms in the mouth, pharynx, and esophagus. Epithelial regions were classified as normal tissue, carcinoma in situ (CIS), or SCC; and the number of each type of region was counted.ResultsCompared with the Glu‐Cer group mice, control group mice more frequently developed individual and multiple tumors of each type, including CIS and SCC, in the mouth, pharynx, or esophagus.ConclusionTumor development was effectively inhibited by dietary Glu‐Cer derived from rice bran, indicating that this and related compounds show promise as prophylactic agents for human HNSCC.Level of EvidenceNA Laryngoscope, 130:E593–E597, 2020
Technical Note: A feasibility study on deep learning‐based radiotherapy dose calculation
Authors: Xing Yixun , Nguyen Dan , Lu Weiguo , Yang Ming , Jiang Steve 
Published: December 2019

PurposeVarious dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate, while the accurate dose engines are often time consuming. In this work, we try to resolve this dilemma by exploring deep learning (DL) for dose calculation.MethodsWe developed a new radiotherapy dose calculation engine based on a modified Hierarchically Densely Connected U‐net (HD U‐net) model and tested its feasibility with prostate intensity‐modulated radiation therapy (IMRT) cases. Mapping from an IMRT fluence map domain to a three‐dimensional (3D) dose domain requires a deep neural network of complicated architecture and a huge training dataset. To solve this problem, we first project the fluence maps to the dose domain using a broad beam ray‐tracing (RT) algorithm, and then we use the HD U‐net to map the RT dose distribution into an accurate dose distribution calculated using a collapsed cone convolution/superposition (CS) algorithm. The model is trained on 70 patients with fivefold cross validation, and tested on a separate 8 patients.ResultsIt takes about 1 s to compute a 3D dose distribution for a typical 7‐field prostate IMRT plan, which can be further reduced to achieve real‐time dose calculation by optimizing the network. The average Gamma passing rate between DL and CS dose distributions for the 8 test patients are 98.5% (±1.6%) at 1 mm/1% and 99.9% (±0.1%) at 2 mm/2%. For comparison of various clinical evaluation criteria (dose‐volume points) for IMRT plans between two dose distributions, the average difference for dose criteria is less than 0.25 Gy while for volume criteria is <0.16%, showing that the DL dose distributions are clinically identical to the CS dose distributions.ConclusionsWe have shown the feasibility of using DL for calculating radiotherapy dose distribution with high accuracy and efficiency.
Exploring network structure and central items of the Narcissistic Personality Inventory
Authors: Briganti Giovanni , Linkowski Paul 
Published: December 2019

AbstractObjectivesThe aim of this work is to explore the Narcissistic Personality Inventory (NPI) using network analysis in a dataset of 942 university students from the French‐speaking part of Belgium.MethodsWe estimated an Ising Model for the forty items in the questionnaire and explored item interconnectedness with strength centrality. We provide in the supplementary materials the dataset used for the analyses as well as the full code to ensure the reproducibility of our results.ResultsThe NPI is presented as an overall positively connected network with items from entitlement, authority and superiority reporting the highest centrality estimates.ConclusionsNetwork analysis highlights new properties of items from the NPI. Future studies should endeavor to replicate our findings in other samples, both clinical and non‐clinical.
Psychotic disorders hospitalizations associated with cannabis abuse or dependence: A nationwide big data analysis
Authors: Gonçalves‐Pinho Manuel , Bragança Miguel , Freitas Alberto 
Published: December 2019

AbstractObjectivesWe aimed to describe and correlate the hospital panorama of psychotic disorders (PD) with cannabis use (CU) trends in all Portuguese public hospitals.MethodsWe conducted a retrospective observational study that analysed all hospitalizations that occurred in Portuguese public hospitals from 2000 to 2015. Hospitalizations with a primary diagnosis of PD or schizophrenia were selected based on Clinical Classification Software diagnostic single‐level 659. Episodes associated with CU were identified by the International Classification of Diseases Version 9, Clinical Modification code 304.3/305.2 that correspond to cannabis dependence/cannabis abuse.ResultsThe number of hospitalizations with a primary diagnosis of PD and schizophrenia associated with CU rose 29.4 times during the study period, from 20 to 588 hospitalizations yearly (2000 and 2015, respectively) with a total of 3,233 hospitalizations and an average episode cost of €3,500. Male patients represented 89.8% of all episodes, and the mean/median age at discharge were 30.66/29.00 years, respectively. From all hospitalizations with a primary diagnosis of PD or schizophrenia, the ones with a secondary diagnosis of CU rose from 0.87% in 2000 to 10.60% in 2015.ConclusionsThe increase on secondary diagnosis coding and the change on cannabis patterns of consumption in Portuguese population with an increasing frequency of moderate/high dosage cannabis consumers may explain the rise on PD hospitalizations.
Integrating decisions with advance supply information in an assemble‐to‐order system
Authors: Chu Jie , Huang Kai 
Published: December 2019

AbstractWe study a periodic‐review assemble‐to‐order (ATO) system with multiple components and multiple products, in which the inventory replenishment for each component follows an independent base‐stock policy and stochastic product demands are satisfied according to a First‐Come‐First‐Served rule. We assume that the replenishment for various component suffers from lead time uncertainty. However, the decision maker has the so‐called advance supply information (ASI) associated with the lead times and thus can take advantage of the information for system optimization. We propose a multistage stochastic integer program that incorporates ASI to address the joint optimization of inventory replenishment and component allocation. The optimal base‐stock policy for the inventory replenishment is determined using the sample average approximation algorithm. Also, we provide a modified order‐based component allocation (MOBCA) heuristic for the component allocation. We additionally consider a special case of the variable lead times where the resulting two‐stage stochastic programming model can be characterized as a single‐scenario case of the proposed multistage model. We carry out extensive computational studies to quantify the benefits of integrating ASI into joint optimization and to explore the possibility of employing the two‐stage model as a relatively efficient approximation scheme for the multistage model.
The role of prescription drugs in female overactive bladder syndrome—A population‐wide cohort study
Authors: Umek Wolfgang , Gleiss Andreas , Bodner‐Adler Barbara , Reichardt Berthold , Rinner Christoph , Heinze Georg 
Published: December 2019

AbstractPurposeOveractive bladder (OAB) syndrome has severe effects on quality of life. Certain drugs are known risk factors for OAB but have not been investigated in a population‐wide cohort. The objective of this study was to investigate the role of prescription drugs in the etiology of the OAB.MethodsRetrospective cohort study using a population‐wide database of 4 185 098 OAB‐naïve women followed Strengthening the Reporting of Observational Studies in Epidemiology guidelines. We investigated the subscription use of anticholinergic medication and 188 chemical substances, which are suspected triggers for OAB (trigger medications [TMs]). We hypothesized a relationship between the prescription for one or more TM and the prescription for anticholinergic medication against OAB (marker medication [MM]).ResultsThe use of MM in Austria increased from 2009 to 2012 on average by 0.025 percentage points per year (95% confidence interval [CI]: 0.015‐0.036). In December 2012, 1 in 123 women filled a prescription for any MM, equaling an average utilization of 0.84%. The relative risk of filling a prescription for a MM 6 months after filling a prescription for a TM was 2.70 (95% CI: 2.64‐2.77). All investigated medication classes showed a higher risk for the prescription for MM. Medication from classes “genitourinary system and sex hormones” and “systemic anti‐infectives” caused the highest increase in risk (109% and 89%, respectively). Prescriptions for class “cardiovascular system” caused the lowest increase in the risk (15%).ConclusionCertain prescription medications are a significant risk factor for the need to take anticholinergic medication as a consequence.