bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methotrexate Hepatotoxicity in Children with Juvenile Idiopathic Arthritis: A Single-Center Study
Authors: Yassin Noha Adel , Haroon Mai , Elhamshary Azza 
Published: December 2020

Background:
Juvenile idiopathic arthritis (JIA) could be disabling if left untreated.
Methotrexate (MTX) is well known as a cornerstone in management. However, its adverse effects
may limit treatment.

Objective:
The objective of this study was to evaluate the frequency of hepatotoxicity based on liver
chemistry in JIA children receiving MTX.

Methods:
An observational case-control study of children with JIA who attend the Pediatric Rheumatology
Unit, Cairo University Pediatric Hospital, Egypt, from January 2018 to December 2018
was carried out. Data were retrieved for 80 children; 50 (62.5%) were prescribed MTX. Their demographic,
clinical characteristics, mean dose, duration of MTX therapy and other medications
were described. Hepatotoxicity was defined as at least one value above the normal laboratory range
of either ALT or AST during the study period.

Results:
Fourteen patients developed hepatotoxicity, giving an incidence of 28%. Children receiving
MTX had higher alanine aminotransferase (ALT) interquartile range (IQR) (26 [21-359] vs.
23[20-32]; p =0.003), higher aspartate aminotransferase (AST) interquartile range (IQR) (31
[22-267] vs. 28[2-35] IU/L; p <0.001), and lower alkaline phosphatase (ALP) mean (±SD)
(98±35.5 vs. 256 ± 39.5 IU/L; p <0.001). However, there were no significant differences in age,
sex, weight, type of JIA, and duration of MTX treatment (p< 0.05).

Conclusion:
Hepatotoxicity due to MTX, based on liver chemistry, is common among children
with JIA.
Prevalence of Anxiety, Depression, Sleep Disturbance, Fibromyalgia, Obesity, and Gastroesophageal Disease in Patients with Rheumatic Diseases
Authors: Azarfar Azin , Ahmed Ali , Bég Shazia 
Published: December 2020

Background:
Patients with rheumatologic disorders often have comorbidities that complicate
their psychological well-being. In this study, we looked at 216 patients with rheumatoid
arthritis (RA), systemic lupus erythematous (SLE), psoriatic arthritis (PsA), and Sjogren’s syndrome
(SS) to determine the prevalence of anxiety, depression, sleep disturbance, fibromyalgia
(FM), obesity (BMI greater than 23), and gastroesophageal disease (GERD) and the correlation between
FM, BMI, disease activity measure, known as Routine Assessment of Patient Index Data 3
(RAPID3).

Methods:
Study participants were 216 rheumatology patients seen at the UCF Pegasus Health Clinic
from November 2011 to May 2014 with one or more of the following diseases: RA, SS, SLE, or
PsA. 116 had rheumatoid arthritis, 27 with systemic lupus erythematous, 22 with psoriatic arthritis,
20 with Sjogren’s syndrome, and 31 with more than one diagnosis. Variables that were collected
from patients’ charts included RAPID3 scores, patient demographics (age, sex), BMI, presence of
GERD, and presence of FM. Each patient was randomly assigned, unique and had an unidentifiable
study number.

Results:
Anxiety, depression, sleep disturbance and obesity were found to be more prevalent in patients
with Sjogren’s syndrome, and fibromyalgia was noted to be more prevalent in patients with
more than 1 diagnosis. The presence of fibromyalgia was significantly correlated with higher
RAPID3 scores in all patients except those with PsA. Significant correlation among higher BMI
and greater RAPID3 scores was found for patients with rheumatoid arthritis and for patients with
Sjogren’s syndrome.

Conclusion:
Our study showed an increased prevalence of anxiety in patients with Sjogren’s syndrome.
Fibromyalgia was found to be related to higher disease activity scores. In RA and SS patients,
BMI was significantly correlated with higher RAPID3 scores. These results provide a basis
for future studies to evaluate these correlations in more detail.
T Allele of the DRD2 Taq1 A Gene Polymorphism Increases the Predisposition to Drug Addiction in Indonesian Population
Authors: Ramadhan Viren , Rahman Faisal , Sadewa Ahmad Hamim , Ikawati Zullies 
Published: December 2020

Background:
Dopamine plays an important role in mediating the rewarding
properties in the abuse of drugs. The Taq1A polymorphism is a commonly studied DRD2
gene variant whereby carriers of the low-function T allele (T/T or T/C genotypes) show
reduced brain dopamine function. Therefore, individuals who have the DRD2 Taq1A polymorphism
will experience higher levels of drug addiction because the T allele is associated
with a reduced number of dopamine binding sites in the brain. A study of this gene
has been conducted in some areas, but there is no research for the population of Indonesia.

Objective:
This study will focus on the frequency of the DRD2 Taq1A gene polymorphism
in the population of Indonesia and define its association with drug addiction.

Methods:
This is a cross sectional study in which 182 subjects were divided into 91 drugaddicted
patients and 91 non-drug-addicted control subjects. The genotype analysis was
carried out by a modified allele-specific Polymerase Chain Reaction (PCR) method.

Results:
The frequency of the T/T and C/T was significantly higher in the addicted than
control subjects. They are 6.6% and 63.7% compared to 0% and 3.3%. Likewise, the T allele
is more frequent in the addicted equal to 38%, compared to only 2% in the control
subjects. The frequency of the T allele between the addicted and control subjects shows a
significant difference (p-value < 0.0001; 95% CI), with the addicted being at a higher risk
of having the T allele (OR = 37.3; 95% CI [11.46-121.29]).

Conclusion:
There is a significant difference in the frequency of the DRD2 Taq1A gene
polymorphism between addicted patients and control subjects. Thus, there is an association
between this gene polymorphism and the development of drug addiction with T allele
increases the predisposition to addiction.
The terminology conflict on efficacy and effectiveness in healthcare
Authors: Porzsolt Franz , Wiedemann Felicitas , Phlippen Meret , Weiss Christel , Weiss Manfred , Schmaling Karen , Kaplan Robert M 
Published: December 2020

Designers and architects created the rule ‘form follows function (FFF)’ for their own profession. Our paper demonstrates that this FFF rule applies equally well to the designers of clinical studies. Four examples present are as follows: disregarding this FFF rule causes an inconsistent terminology to differentiate between efficacy and effectiveness, inconsistent differentiation of efficacy and effectiveness interferes with the consistent interpretation of the results of clinical studies, inconsistent interpretation of clinical studies results in an unexpectedly variance of recommendations in clinical guidelines and the fusion of the FFF designer rule and of the demands of Cochrane and Bradford Hill (‘can it work?’, ‘does it work?’ and ‘is it worth it?’) avoids the terminology problem and its misleading consequences. This strategy is presented.
A ABORDAGEM ECOPEDAGÓGICA PARA SENSIBILIZAÇÃO AMBIENTAL NA EDUCAÇÃO INFANTIL
Authors: Schwalm Fernanda , Lima Robaina José Vicente 
Published: December 2020

O presente artigo consiste no relato de uma experiência pedagógica realizada em uma escola de Educação Infantil, na cidade de Porto Alegre/RS. O projeto seguiu os princípios da Ecopedagogia como modelo pedagógico para a sensibilização ambiental e para a sustentabilidade socioambiental. Utilizando material didático e fundamentos estéticos que abordaram conceitos, atitudes e valores pertinentes ao propósito da Educação Ambiental, a proposta buscou possibilitar novas vivências sensoriais relacionando o ensino de Ciências, a Educação Ambiental e a alfabetização científica na primeira infância, através de experiências que envolvem a experimentação artística e científica. A metodologia consistiu em montar um projeto de trabalho a partir de um tema gerador que surgiu a partir do interesse das crianças: a transformação da natureza. A ideia central foi envolver os alunos no processo criativo e na construção dos conhecimentos com significados reais, a partir das atividades realizadas. O objetivo principal do trabalho consistiu na promoção de vivências e na formação de valores contextualizados com o cotidiano dos educandos, tendo como elemento norteador a sensibilização ambiental para construção da cidadania sustentável. Ao longo do projeto foi possível observar que as atividades ao ar livre foram as que causaram maior entusiasmo e curiosidade entre os alunos. Aprovando assim, as ideias da Ecopedagogia que sugerem o maior contato possível com os elementos da natureza durante a primeira infância para o e desenvolvimento da interpretação de mundo conforme os principios éticos da sustentabilidade social e ambiental. O objetivo do trabalho não foi mensurar o nível de aprendizagem das crianças após a realização do projeto. No entanto, pretende-se relatar atividades e seus percursos metodológicos para que possam ser aplicadas na educação infantil. Facilitando as práticas de Educação Ambiental nas escolas, para que novas relações de pertencimento ao meio e respeito pela natureza possam ser criadas desde os primeiros anos de vida.
Zastosowanie modeli logitowych do zdiagnozowania zagrożenia bankructwem przedsiębiorstw
Authors: Lichota Wojciech 
Published: December 2020

W artykule zostały zaprezentowane wybrane modele regresji logistycznej, które służą do analizy przedsiębiorstw w zakresie zagrożenia bankructwem jak i zmiany w sytuacji finansowej. Jak wynika z literatury z zakresu finansów do oceny kondycji finansowej przedsiębiorstwa należy zastosować odpowiednie metody. Błędna ocena może przynieść przykre konsekwencje dla przedsiębiorstwa, w postaci podjęcia nietrafionych decyzji przez zarządzających, odmowy udzielenia kredytu bankowego lub niepodjęcia współpracy przez dostawców i odbiorców. Celem artykułu była weryfikacja skuteczności predykcji 12 modeli regresji logistycznej, które pozwalają na dokonanie oceny zagrożenia bankructwem przedsiębiorstwa a także zajęcia stanowiska odnośnie przyszłej kondycji finansowej. Próba badawcza wynosiła 40 przedsiębiorstw, w tym 8 przedsiębiorstw, dla których został złożony wniosek o upadłość. Jak wynika z przeprowadzonych badań, poszczególne modele odznaczają się różną sprawnością ogólną, która wyniosła od 54% do 98%. Ponadto wykazano, że wraz ze wzrostem wskaźników analizy finansowej użytych w konstrukcji funkcji nie zwiększa się sprawność poszczególnych modeli. Autor podsumowuje, że w celu uniknięcia ryzyka przeprowadzenia niewiarygodnej oceny kondycji finansowej przedsiębiorstwa, należy zastosować co najmniej kilka modeli logitowych.
LIQUIDITY TRAP IN THE UNITED STATES, THE EURO AREA AND JAPAN
Authors: Misztal Piotr 
Published: December 2020

When a country falls into a liquidity trap it means that its central bank lacks an effective expansionary monetary policy aimed at increasing consumption and investment demand. Market participants (households and enterprises), instead of increasing demand, accumulate a growing money supply in the form of cash. Keynes argued that for an economy in a liquidity trap, the only way to increase demand in the country and to stimulate the economy is to conduct expansionary fiscal policy by increasing government spending or reducing taxes. The aim of the research is to verify the empirical hypothesis of the liquidity trap in three of the largest economies in the world, formerly known as the Global Triad (i.e. the USA, the euro zone and Japan), after the 2008 financial crisis. Research methods based on literature studies in macroeconomics and finance, as well as statistical methods, were used in the study. All statistical data came from the statistical office of the European Union – EUROSTAT, and from the statistical database of the United Nations Conference on Trade and Development - UNCTADstat.
Literatura e literalidade: a cristoforia hagiográfica em São Julião Hospitaleiro, de Flaubert e São Cristóvão, de Eça de Queiroz
Authors: Mikail Abud Filho Regis 
Published: December 2020

Nossa proposta é investigar a representação da cristoforia em duas narrativas do século 19: a Lenda de São Julião Hospitaleiro, de Gustave Flaubert, e São Cristóvão, de Eça de Queiroz. Por "cristoforia" entendemos o significado etimológico e literal do transporte do Cristo. Ambas lendas hagiográficas reescritas ganham novas implicações de ordem semântica e estética. A imitatio Christi se desdobra tanto no âmbito literário quanto no âmbito moral: lançar, transportar, transladar a palavra do Cristo, em narrativas nas quais o santo por vezes ganha traços de personagem de ficção a partir da “forma simples” que é a lenda. De que maneira tal retomada da narrativa exemplar consistiria em uma subversão da própria vida dos santos ? Partimos de dois topoï (os elementos pagãos e diabólicos bem como o transporte do Cristo e a ascensão ao céu) para indagarmos se, do ponto de vista analítico, a narrativa hagiográfica – cujo objetivo é transmitir um modelo exemplar ao leitor – passa por uma subversão literal e literária através da transferência da lenda à narrativa de ficção.
Silêncio e Dignidade na contemporaneidade
Authors: Moure Walter , Genaro Fernando 
Published: December 2020

Resumo: O artigo aborda o silêncio e a dignidade humana como facetas do sofrimento ético recorrente na contemporaneidade. Os autores, psicanalistas, refletiram a partir das suas testemunhas na clínica, em especial, sobre uma crônica de um paciente, com valor literário, originada durante o seu processo psicanalítico. Em seguida, buscaram uma articulação dessa problemática privilegiando os escritos inéditos de Lévinas. Para tanto, empregou-se um diálogo entre a crônica e a conferência de Lévinas sobre a palavra e silêncio, numa perspectiva de fazer reverberar considerações sobre a necessidade ética da palavra a ser ouvida, e não capturada pelo ser, assim como questionaram a viabilidade do cuidar em psicologia frente ao sofrimento contemporâneo. Abstract: The article addresses silence and human dignity as facets of contemporary ethical suffering. The authors, psychoanalysts, reflected from their witnesses in the clinic, in particular, about a chronicle of a patient, with literary value, originated during his psychoanalytic process. Then, they sought an articulation of this problem, privileging Lévinas' unpublished writings. To this end, a dialogue was used between the chronicle and Lévinas' conference on the word and silence, with a view to reverberating considerations about the ethical need for the word to be heard, and not captured by the being, just as they questioned the viability of the caring in psychology in the face of contemporary suffering.
TOPOLOGIA DO CIBERESPAÇO: redes sociais, aprendizagem colaborativa e matemática para além da sala de aula
Authors: Carius Ana Carolina 
Published: December 2020

O presente trabalho apresenta o estudo da relação social e colaborativa no ciberespaço entre os estudantes de uma turma de ensino médio. Foi escolhido, como público participante, o grupo de estudantes matriculados em um curso técnico em química integrado de uma escola técnica da região metropolitana do estado do Rio de Janeiro. Objetivou-se, a partir da proposição de uma atividade em grupo à qual integrou matemática e química, analisar o comportamento dos estudantes no ciberespaço, do ponto de vista colaborativo, e a importância desta interação para a realização da atividade. Como metodologia de pesquisa se utilizou a pesquisa-ação para a análise offline dos atores envolvidos e a observação participante para a análise online dos mesmos atores, atuantes em uma rede social. A Análise de Redes Sociais (ARS) foi o instrumento usado para o mapeamento do ciberespaço e caracterização das interações entre os estudantes. Com base nos resultados da ARS, em conjunto com a análise dos trabalhos apresentados pelos grupos envolvidos na atividade, concluiu-se que os grupos com maior interação na rede social obtiveram maior competência na apresentação do produto final da atividade, bem como compreenderam com maior nitidez os objetivos desta, desenvolvendo diversas habilidades extracurriculares. Portanto o ciberespaço, particularmente representado pelas redes sociais, conduz a uma nova forma de construção e disseminação do conhecimento, modificando as relações sociais também no ambiente educacional.
PENGARUH PEMBERIAN SUPLEMEN TEPUNG TEMULAWAK (Curcuma xanthorrhiza Roxb) TERHADAP KONSUMSI PROTEIN KASAR, KECERNAAN PROTEIN KASAR DAN PRODUKSI PROTEIN SUSU PADA SAPI PERAH LAKTASI
Authors: Setiadi Dedy , Hartanto Rudy , Harjanti Dian Wahyu 
Published: December 2020

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian suplemen tepung temulawak (Curcuma xanthorriza Roxb) terhadap konsumsi PK dan produksi protein susu sapi perah laktasi. Materi yang digunakan adalah 12 ekor sapi perah Friesian Holstein (FH) dengan pengelompokan berdasarkan produksi susu yang ada di KTT Wahyu Agung, Getasan. Rancangan percobaan yang digunakan adalah rancangan acak kelompok (RAK) dengan 2 perlakuan dan 6 kelompok berdasarkan produksi susu. Perlakuan yang diterapkan yaitu T0 = sebagai kontrol, T1 = suplemen temulawak 1% kebutuhan BK. Parameter yang diamati meliputi jumlah konsumsi protein kasar pakan, kecernaan protein kasar dan produksi protein susu. Data dianalisis menggunakan analisis ragam taraf signifikan 5%. Hasil penelitian menunjukkan bahwa rataan konsumsi protein kasar T0 sebesar 1,589 kg/ekor/hari, T1 sebesar 1,599 kg/ekor/hari, kecernaan protein kasar T0 sebesar 72,70%, T1 sebesar 75,68% dan produksi protein susu T0 sebesar 0,210 kg/ekor/hari, T1 sebesar 0,205 kg/ekor/hari. Hal tersebut menunjukkan pemberian suplemen tepung temulawak 1% kebutuhan BK tidak berpengaruh nyata terhadap konsumsi protein kasar, kecernaan protein kasar dan produksi protein susu. Kesimpulan penelitian adalah penambahan suplemen temulawak sebanyak 1% kebutuhan BK belum mampu meningkatkan konsumsi protein kasar, kecernaan protein kasar dan produksi protein susu sapi perah laktasi. Kata kunci: Kecernaan, Konsumsi, Protein kasar, Protein susu, Temulawak
Multicenter study to investigate factors associated with change in rectal temperature during anesthesia in dogs
Authors: Clark-Price Stuart C. , Fischer Berit L. , Kirwin Kevin L. , Keating Stephanie C. J. , Auckburally Adam , Flaherty Derek 
Published: December 2020

OBJECTIVE
To determine factors associated with change in rectal temperature (RT) of dogs undergoing anesthesia.

ANIMALS
507 dogs.

PROCEDURES
In a prospective observational study, the RT of dogs undergoing anesthesia at 5 veterinary hospitals was recorded at the time of induction of anesthesia and at the time of recovery from anesthesia (ie, at the time of extubation). Demographic data, body condition score, American Society of Anesthesiologists (ASA) physical status classification, types of procedure performed and medications administered, duration of anesthesia, and use of heat support were also recorded. Multiple regression analysis was performed to determine factors that were significantly associated with a decrease or an increase (or no change) in RT. Odds ratios were calculated for factors significantly associated with a decrease in RT.

RESULTS
Among the 507 dogs undergoing anesthesia, RT decreased in 89% (median decrease, −1.2°C [-2.2°F]; range, −0.1°C to −5.7°C [–0.2°F to −10.3°F]), increased in 9% (median increase, 0.65°C [1.2°F]; range, 0.1°C to 2.1°C [3.8°F]), and did not change in 2%. Factors that significantly predicted and increased the odds of a decrease in RT included lower weight, ASA classification > 2, surgery for orthopedic or neurologic disease, MRI procedures, use of an α2-adrenergic or μ-opioid receptor agonist, longer duration of anesthesia, and higher heat loss rate. Lack of μ-opioid receptor agonist use, shorter duration of anesthesia, and lower heat loss rate were significantly associated with an increase in RT.

CONCLUSIONS AND CLINICAL RELEVANCE
Multiple factors that were associated with a decrease in RT in dogs undergoing anesthesia were identified. Knowledge of these factors may help identify dogs at greater risk of developing inadvertent perianesthetic hypothermia.
Evaluation of a staged technique of immediate decompressive and delayed surgical treatment for gastric dilatation-volvulus in dogs
Authors: White Russell S. , Sartor Angela J. , Bergman Philip J. 
Published: December 2020

OBJECTIVE
To evaluate a staged technique of immediate decompressive and delayed surgical treatment for gastric dilatation-volvulus (GDV) in dogs.

ANIMALS
41 client-owned dogs with confirmed GDV from 2012 through 2016.

PROCEDURES
Medical record data were collected regarding patient signalment, diagnostic test results, gastric lavage findings, surgical findings, and short-term survival status. For all dogs, gastric decompression was performed by orogastric intubation and gastric lavage in the same anesthetic episode. If this stage was successful, subsequent corrective surgery (laparotomy and gastropexy) was delayed and performed in a second anesthetic episode.

RESULTS
6 dogs underwent corrective surgery in the same anesthetic session as for decompression and stabilization, 2 of which had gastric necrosis. Thirty-five dogs underwent corrective surgery in a second anesthetic episode a mean of 22.3 hours (range, 5.25 to 69.75 hours) after presentation, during which gastric necrosis was identified in 2 dogs. The mortality rate for delayed-surgery patients was 9% (3/35). Time from presentation to surgery was not associated with surgeon subjective assessment of gastric health status or mortality rate. Intraoperative identification of gastric necrosis was associated with nonsurvival. Single plasma lactate concentrations and percentage change in serial lactate concentrations were associated with intraoperative gastric health status and mortality rate.

CONCLUSIONS AND CLINICAL RELEVANCE
The observed mortality rate for delayed-surgery patients was comparable to rates reported for other GDV treatment techniques. Results suggested that delaying corrective surgery is possible for certain dogs, but careful case selection would be important and no reliable preoperative case selection criteria were identified. Additional research is needed to further investigate the potential risks and benefits of staged versus immediate surgical treatment of GDV in dogs.