bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumption of fruit and vegetables and the risk of type 2 diabetes: a 4-year longitudinal study among Swedish adults
Authors: Ahmed Arif , Lager Anton , Fredlund Peeter , Elinder Liselotte Schäfer 
Published: April 2020

Abstract
A low intake of fruit and vegetables is a significant contributor to the global burden of disease. The aim of this study was to estimate the size of the risk of type 2 diabetes (T2D) of a low intake and to investigate possible sex differences. In this regard, this study used a longitudinal data from the Stockholm Public Health Cohort located in Sweden, collected in 2010 and 2014. The analysis included 14 718 men and 20 589 women aged 25 to 84 years. Fruit and vegetable intake, separately <2 servings/d or combined <4 servings/d (one serving corresponding to 100 g) was set as a cut-point for low intake. The sex difference at baseline was examined. Sex-stratified logistic regression was performed with onset of T2D as the outcome and fruit and vegetable intake at baseline as the exposure with adjustment for other known risk factors. Results indicate that men consumed significantly (P < 0⋅001) less fruit and vegetables compared with women. A 62 % higher risk to develop T2D over the 4-year period was observed in men who had low vegetable intake compared with high intake after adjusting for age, education, BMI, smoking, alcohol and physical activity (OR 1⋅62; 95 % CI 1⋅00, 2⋅63). In women, a significantly higher risk of T2D was also observed with a low intake of vegetables, but not after adjustment. The present study suggests that higher consumption of vegetables seems to be protective for the onset of T2D in men. Thus, increasing the intake of vegetables in men should be a public health priority.
A non-local continuum poro-damage mechanics model for hydrofracturing of surface crevasses in grounded glaciers
Authors: Duddu Ravindra , Jiménez Stephen , Bassis Jeremy 
Published: April 2020

AbstractHydrofracturing can enhance the depth to which crevasses propagate and, in some cases, allow full depth crevasse penetration and iceberg detachment. However, many existing crevasse models either do not fully account for the stress field driving the hydrofracture process and/or treat glacier ice as elastic, neglecting the non-linear viscous rheology. Here, we present a non-local continuum poro-damage mechanics (CPDM) model for hydrofracturing and implement it within a full Stokes finite element formulation. We use the CPDM model to simulate the propagation of water-filled crevasses in idealized grounded glaciers, and compare crevasse depths predicted by this model with those from linear elastic fracture mechanics (LEFM) and zero stress models. We find that the CPDM model is in good agreement with the LEFM model for isolated crevasses and with the zero stress model for closely-spaced crevasses, until the glacier approaches buoyancy. When the glacier approaches buoyancy, we find that the CPDM model does not allow the propagation of water-filled crevasses due to the much smaller size of the tensile stress region concentrated near the crevasse tip. Our study suggests that the combination of non-linear viscous and damage processes in ice near the tip of a water-filled crevasse can alter calving outcomes.
Two new early Asteroidea (Echinodermata) and early asteroid evolution
Authors: Blake Daniel B. , Gahn Forest J. , Guensburg Thomas E. 
Published: April 2020

AbstractAerliceaster nexosusn. gen. n. sp. (Echinodermata), one of the oldest of known asteroids, is based on six specimens from the Floian (Early Ordovician) Garden City Formation of Idaho, andKolataster perplexusn. gen. n. sp. is based on two specimens from the Sandian (Late Ordovician) Mifflin Formation of Illinois. Although the asterozoan skeleton is subdivided into few ossicular categories, evolutionary derivations of all the categories are not fully established, and therefore published evaluations differ. Beginning with phylogenetic work placing asteroid ancestry within the Somasteroidea together with the new taxa described herein, aspects of early asteroid morphology are evaluated and ambiguities in need of further study identified. Uncertainties are considered to be founded in rapid early asterozoan diversification and the scanty fossil record.UUID:http://zoobank.org/b43d07cc-c8fb-4a84-bc6f-40aa6e0daea2
Artificial intelligence to detect tympanic membrane perforations
Authors: Habib A-R , Wong E , Sacks R , Singh N 
Published: April 2020

AbstractObjectiveTo explore the feasibility of constructing a proof-of-concept artificial intelligence algorithm to detect tympanic membrane perforations, for future application in under-resourced rural settings.MethodsA retrospective review was conducted of otoscopic images analysed using transfer learning with Google's Inception-V3 convolutional neural network architecture. The ‘gold standard’ ‘ground truth’ was defined by otolaryngologists. Perforation size was categorised as less than one-third (small), one-third to two-thirds (medium), or more than two-thirds (large) of the total tympanic membrane diameter.ResultsA total of 233 tympanic membrane images were used (183 for training, 50 for testing). The algorithm correctly identified intact and perforated tympanic membranes (overall accuracy = 76.0 per cent, 95 per cent confidence interval = 62.1–86.0 per cent); the area under the curve was 0.867 (95 per cent confidence interval = 0.771–0.963).ConclusionA proof-of-concept image-classification artificial intelligence algorithm can be used to detect tympanic membrane perforations and, with further development, may prove to be a valuable tool for ear disease screening. Future endeavours are warranted to develop a point-of-care tool for healthcare workers in areas distant from otolaryngology.
Influence of timing of Palmer amaranth control in dicamba-resistant cotton on yield and economic return
Authors: Inman Matthew D. , Jordan David L. , Vann Matthew C. , Hare Andrew T. , York Alan C. , Cahoon Charles W. 
Published: April 2020

AbstractGlyphosate-resistant (GR) Palmer amaranth continues to be challenging to control across the U.S. cotton belt. Timely application of POST herbicides and herbicides applied at planting or during the season with residual activity are utilized routinely to control this weed. Although glyphosate controls large Palmer amaranth that is not GR, herbicides such as glufosinate used in resistance management programs for GR Palmer amaranth must be applied when weeds are small. Dicamba can complement both glyphosate and glufosinate in controlling GR and glyphosate-susceptible (GS) biotypes in resistant cultivars. Two studies were conducted to determine Palmer amaranth control, weed biomass, and cotton yield, as well as to estimate economic net return when herbicides were applied 2, 3, 4, and 5 wk after planting (WAP). In one experiment POST-only applications were made. In the second experiment PRE herbicides were included. In general, Palmer amaranth was controlled at least 98% by herbicides applied at least three times regardless of timing of application or herbicide sequence. Glyphosate plus dicamba applied at 4 and 5 WAP controlled Palmer amaranth similarly compared to three applications by 8 WAP; however, yield was reduced 23% because of early-season interference. The inclusion of PRE herbicides benefited treatments that did not include herbicides applied 2 or 3 WAP. Glyphosate plus dicamba applied as the only herbicides 5 WAP provided 69% control of Palmer amaranth. PRE herbicides increased control to 96% for this POST treatment. Economic returns were similar when three or more POST applications were applied, with or without PRE herbicides.
Global Estimates of Reach‐Level Bankfull River Width Leveraging Big Data Geospatial Analysis
Authors: Lin Peirong , Pan Ming , Allen George H. , de Frasson Renato Prata , Zeng Zhenzhong , Yamazaki Dai , Wood Eric F. 
Published: April 2020

AbstractRecent progress in remote sensing has snapshotted unprecedented numbers of river planform geometry, providing opportunity to revisit the oversimplified channel shape parameterizations in global hydrologic models. This study leveraged two recent Landsat‐derived global river width databases and created a reach‐level width dataset to measure the validity of model parameterizations at ~1.6 million kilometers of rivers in length. By showing state‐of‐the‐art parameterization schemes only capture 30–40% of the width variance globally, we developed a machine learning (ML) approach surveying 16 environmental covariates, which considerably improved the predictive power (R2 = 0.81 and 0.77 for two testing cases). Beyond the commonly discussed upstream basin conditions, ML revealed that local physiographic factors and human interference are also important covariates for width variability. Finally, we applied the ML model to estimate bankfull river width, creating a new reach‐level dataset for use in global hydrodynamic modeling.
Estimating Southern Ocean Storm Positions With Seismic Observations
Authors: Hell Momme C. , Gille Sarah T. , Cornuelle Bruce D. , Miller Arthur J. , Bromirski Peter D. , Crawford Alex D. 
Published: April 2020

AbstractSurface winds from Southern Ocean cyclones generate large waves that travel over long distances (>1,000 km). Wave generation regions are often colocated with enhanced air‐sea fluxes and upper ocean mixing. Ocean wave spectra contain information about storm wind speed, fetch size, and intensity at their generation site. Two years of seismic observations on the Ross Ice shelf, combined with modern optimization (machine learning) techniques, are used to trace the origins of wave events in the Southern Ocean with an accuracy of ±110 km and ±2 hr from a hypothetical point source. The observed spectral energy attenuated within sea ice and in the ice shelf but retains characteristics that can be compared to parametric wave models. Comparison with the Modern‐Era Retrospective Analysis for Research and Applications, Version 2, and ERA5 reanalyses suggests that less than 45% of ocean swell events can be associated with individual Southern Ocean storms, while the majority of the observed wave events cannot be matched with Southern Ocean high wind events. Reanalysis cyclones and winds are often displaced by about 350 km or 10 hr in Modern‐Era Retrospective Analysis for Research and Applications, Version 2, and ERA5 compared to the most likely positions inferred from the seismic spectra. This high fraction of displaced storms in reanalysis products over the South Pacific can be explained by the limited availability of remote sensing observations, primarily caused by the presence of sea ice. Deviation of wave rays from their great circle path by wave‐current interaction plays a minor role.
Real-time transition dynamics and stability of chip-scale dispersion-managed frequency microcombs
Authors: Li Yongnan , Huang Shu-Wei , Li Bowen , Liu Hao , Yang Jinghui , Vinod Abhinav Kumar , Wang Ke , Yu Mingbin , Kwong Dim-Lee , Wang Hui-Tian , Wong Kenneth Kin-Yip , Wong Chee Wei 
Published: April 2020

AbstractFemtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy, all-optical atomic clocks, and measurements of ultrafast dynamics. Recently frequency microcombs based on nonlinear microresonators have been examined, exhibiting remarkable precision approaching that of laser frequency combs, on a solid-state chip-scale platform and from a fundamentally different physical origin. Despite recent successes, to date, the real-time dynamical origins and high-power stabilities of such frequency microcombs have not been fully addressed. Here, we unravel the transitional dynamics of frequency microcombs from chaotic background routes to femtosecond mode-locking in real time, enabled by our ultrafast temporal magnifier metrology and improved stability of dispersion-managed dissipative solitons. Through our dispersion-managed oscillator, we further report a stability zone that is more than an order-of-magnitude larger than its prior static homogeneous counterparts, providing a novel platform for understanding ultrafast dissipative dynamics and offering a new path towards high-power frequency microcombs.
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
Authors: Lu Kang , Li Bo , Zhang Hui , Xu Zhijian , Song Dongliang , Gao Lu , Sun Haiguo , Li Liping , Wang Yingcong , Feng Qilin , Chen Gege , Hu Liangning , Wei Rong , Xie Yongsheng , Yu Dandan , Wu Xiaosong , Zhu Weiliang , Shi Jumei 
Published: April 2020

AbstractDiffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous malignant tumor characterized by diffuse growth. DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL. This study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell lines. Cell Counting Kit-8 (CCK-8) and plate colony formation assays were used to evaluate cell proliferation levels. Flow cytometry was employed to analyze apoptosis and the cell cycle, and western blotting was used to quantify the expression of cell cycle regulators. The results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal cells. Moreover, DCZ0858 initiated cell apoptosis via both internal and external apoptotic pathways. DCZ0858 also induced cell cycle arrest in the G0/G1 phase, thereby controlling cell proliferation. Further investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 treatment. Knockdown of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells, while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL cells. Moreover, a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib, and combining the two could significantly enhance cancer-suppressive signaling. Tumor xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs, findings that were consistent with the in vitro data. In summary, DCZ0858 is a promising drug for the treatment of DLBCL.
Associations between calcium and magnesium intake and the risk of incident oesophageal cancer: an analysis of the NIH-AARP Diet and Health Study prospective cohort
Authors: Shah Shailja C. , Dai Qi , Zhu Xiangzhu , Peek Richard M. , Roumie Christianne , Shrubsole Martha J. 
Published: April 2020

Abstract
Background
Risk reduction through dietary modifications is an adjunct strategy for prevention of oesophageal cancer, a leading cause of cancer-related mortality and morbidity worldwide. We aimed to estimate the association between calcium and magnesium intakes and incident oesophageal cancer (OC).

Methods
We conducted a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort. We used multivariable Cox proportional hazard modeling to estimate the association between total intakes and incident OC overall and by histology (oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC)). Sensitivity and stratified analyses were performed.

Results
Among 536,359 included respondents, 1414 incident OCs occurred over 6.5 million person-years follow-up time. Increasing dietary calcium intake was associated with an adjusted 32–41% lower risk of OSCC compared to the lowest quartile (p-trend 0.01). There was a positive association between increasing magnesium intake and OAC risk, but only among participants with low calcium:magnesium intake ratios (p-trend 0.04). There was a significant interaction with smoking status.

Conclusions
Based on a retrospective analysis of the NIH-AARP Diet and Health Study prospective cohort, dietary intakes of calcium and magnesium were significantly associated with risk of OSCC and, among certain participants, OAC, respectively. If validated, these findings could inform dietary modifications among at-risk individuals. Mechanistic investigations would provide additional insight.
Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression
Authors: Toscan Cara E. , Jing Duohui , Mayoh Chelsea , Lock Richard B. 
Published: April 2020

Abstract
Background
Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Glucocorticoids form a critical component of chemotherapy regimens and resistance to glucocorticoid therapy is predictive of poor outcome. We have previously shown that glucocorticoid resistance is associated with upregulation of the oncogene C-MYC and failure to induce the proapoptotic gene BIM.

Methods
A high-throughput screening (HTS) campaign was carried out to identify glucocorticoid sensitisers against an ALL xenograft derived from a glucocorticoid-resistant paediatric patient. Gene expression analysis was carried out using Illumina microarrays. Efficacy, messenger RNA and protein analysis were carried out by Resazurin assay, reverse transcription-PCR and immunoblotting, respectively.

Results
A novel glucocorticoid sensitiser, 2-((4,5-dihydro-1H-imidazol-2-yl)thio)-N-isopropyl-N-phenylacetamide (GCS-3), was identified from the HTS campaign. The sensitising effect was specific to glucocorticoids and synergy was observed in a range of dexamethasone-resistant and dexamethasone-sensitive xenografts representative of B-ALL, T-ALL and Philadelphia chromosome-positive ALL. GCS-3 in combination with dexamethasone downregulated C-MYC and significantly upregulated BIM expression in a glucocorticoid-resistant ALL xenograft. The GCS-3/dexamethasone combination significantly increased binding of the glucocorticoid receptor to a novel BIM enhancer, which is associated with glucocorticoid sensitivity.

Conclusions
This study describes the potential of the novel glucocorticoid sensitiser, GCS-3, as a biological tool to interrogate glucocorticoid action and resistance.
Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression
Authors: Zang Xueyan , Gu Jianmei , Zhang Jiayin , Shi Hui , Hou Sinan , Xu Xueying , Chen Yanke , Zhang Yu , Mao Fei , Qian Hui , Zhu Taofeng , Xu Wenrong , Zhang Xu 
Published: April 2020

AbstractLong non-coding RNAs (LncRNAs) have been suggested as important regulators of cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless, the biological roles and clinical significance of lncRNA UFC1 in NSCLC remain unclear. We detected the expression of UFC1 in tumor tissues, serum, and serum exosomes of NSCLC patients by qRT-PCR. Gene overexpression or silencing were used to examine the biological roles of UFC1 in NSCLC. RNA immunoprecipitation and ChIP assays were performed to evaluate the interaction between UFC1 and enhancer of zeste homolog 2 (EZH2) and the binding of EZH2 to PTEN gene promoter. Rescue study was used to access the importance of PTEN regulation by UFC1 in NSCLC progression. UFC1 expression was upregulated in tumor tissues, serum, and serum exosomes of NSCLC patients and high level of UFC1 was associated with tumor infiltration. UFC1 knockdown inhibited NSCLC cell proliferation, migration and invasion while promoted cell cycle arrest and apoptosis. UFC1 overexpression led to the opposite effects. Mechanistically, UFC1 bound to EZH2 and mediated its accumulation at the promoter region of PTEN gene, resulting in the trimethylation of H3K27 and the inhibition of PTEN expression. UFC1 knockdown inhibited NSCLC growth in mouse xenograft tumor models while the simultaneous depletion of PTEN reversed this effect. NSCLC cells derived exosomes could promote NSCLC cell proliferation, migration and invasion through the transfer of UFC1. Moreover, Exosome-transmitted UFC1 promotes NSCLC progression by inhibiting PTEN expression via EZH2-mediated epigenetic silencing. Exosome-mediated transmit of UFC1 may represent a new mechanism for NSCLC progression and provide a potential marker for NSCLC diagnosis.
LncRNA GAS5 promotes apoptosis as a competing endogenous RNA for miR-21 via thrombospondin 1 in ischemic AKI
Authors: Geng Xuemei , Song Nana , Zhao Shuan , Xu Jiarui , Liu Yong , Fang Yi , Liang Mingyu , Xu Xialian , Ding Xiaoqiang 
Published: April 2020

AbstractMounting evidence has indicated that long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) played important roles in renal ischemia/reperfusion (I/R) injury. However, the involvement of lncRNA growth arrest specific 5 (GAS5) in acute kidney injury (AKI) remained largely unexplored. This study aimed to determine possible mechanisms of GAS5 in the renal I/R process. We found that GAS5, noticeably upregulated by renal I/R injury, was further suppressed by delayed IPC while knockdown of miR-21 in vivo before IPC could significantly increased the GAS5 levels. Concurrently, TSP-1 was negatively regulated by miR-21 in vivo and vitro. Additionally, Reciprocal repression of GAS5 and miR-21 was identified. Knockdown of miR-21 in H6R0.5 treated HK-2 cells promoted apoptosis. Co-transfection of miR-21 mimic and pcDNA-GAS5 or pcDNA-Vector were performed, results of which showed that inhibition of miR-21 on TSP-1 could be rescued by overexpression of GAS5. This study suggested that GAS5 facilitated apoptosis by competitively sponging miR-21, which negatively regulated TSP-1 in renal I/R injury. This novel regulatory axis could act as a therapeutic target for AKI in the future.
Phasor field diffraction based reconstruction for fast non-line-of-sight imaging systems
Authors: Liu Xiaochun , Bauer Sebastian , Velten Andreas 
Published: April 2020

AbstractNon-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel point scanning detection, current reconstruction algorithms for such systems have computational and memory requirements that prevent real-time NLOS imaging. Existing real-time demonstrations also use retroreflective targets and reconstruct at resolutions far below the hardware limits. Our method presented here enables the reconstruction of room-sized scenes from non-confocal, parallel multi-pixel measurements in seconds with less memory usage. We anticipate that our method will enable real-time NLOS imaging when used with emerging single-photon avalanche diode array detectors with resolution only limited by the temporal resolution of the sensor.
Analog content-addressable memories with memristors
Authors: Li Can , Graves Catherine E. , Sheng Xia , Miller Darrin , Foltin Martin , Pedretti Giacomo , Strachan John Paul 
Published: April 2020

AbstractA content-addressable memory compares an input search word against all rows of stored words in an array in a highly parallel manner. While supplying a very powerful functionality for many applications in pattern matching and search, it suffers from large area, cost and power consumption, limiting its use. Past improvements have been realized by using memristors to replace the static random-access memory cell in conventional designs, but employ similar schemes based only on binary or ternary states for storage and search. We propose a new analog content-addressable memory concept and circuit to overcome these limitations by utilizing the analog conductance tunability of memristors. Our analog content-addressable memory stores data within the programmable conductance and can take as input either analog or digital search values. Experimental demonstrations, scaled simulations and analysis show that our analog content-addressable memory can reduce area and power consumption, which enables the acceleration of existing applications, but also new computing application areas.