bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’Esprit du Sacré: Le Corbusier and the necessary Utopia of Sainte Marie de La Tourette
Authors: Alison Aurosa , Cafiero Gioconda 
Published: November 2019

“L’homme qui recherche l’harmonie a le sens du sacré”. In this way Le Corbusier claims the main difference between holiness and spirituality. In the omitted comparison, it is clear that the Architect's main interest is to highlight the strong laical and spiritual character of which is harmonious both in Nature and Architecture. Thanks to this approach, the democratic reception of the spiritual feeling overcomes the sacred one which remains linked to semantics stratifications that still require interpretation. In order to develop a democratic vision to community life, Le Corbusier entrusts the rules of a daily living, with the contingent possibilities of a community such as the Dominican one and also with the need to individual seclusion, celebrating immanence and silence. “Loger dans le silence des hommes de prière et d’étude et leur construire une église”.The celebration of both prayer and community life is what Le Corbusier wants to achieve, without distracting attention from the main purpose of the spiritual and individual growth, that nourishes the utopian function of this project. This shares a common research with the other architectures conceived for a community life such as l’Unité d’Habitation or the Swiss Pavilion. This is the way the liturgical spaces welcome daily life evaluating un homme de 24 heures, arranging an hermeneutical relationship between places for gathering and meditation. From this we can acknowledge that architecture of the Le Corbusier’s Convent, allows holy inspirational feelings among liturgical and environmental spaces. All this is due to an hard intellectual work based on humanism, far from faith, but open to spiritual values and mystical feelings which place Beauty as an existential motivation for a religious work, including human dimension and the answers to his needs.
Swimming Impacts on Pancreatic Inflammatory Cytokines, miR-146a and NF-кB Expression Levels in Type-2 Diabetic Rats
Authors: Alipour Mohammad Reza , Yousefzade Nasibeh , Bavil Fariba Mirzaei , Naderi Roya , Ghiasi Rafighe 
Published: November 2019

Background:
Obesity-induced chronic inflammation is a key component in the pathogenesis
of insulin resistance and type-2 diabetes

Objective:
This study aimed to evaluate the effect of swimming exercise on pancreatic expression levels
of inflammatory cytokines, miR-146a and NF-кB in type-2 diabetic male rats.

Method:
Twenty- eight male Wistar rats were divided into four groups: control (Con), exercise, diabetes
and diabetic exercise (n = 7). Diabetes induction performed by the combination of high-fat diet
(HFD, 4 weeks) and streptozotocin (35 mg/kg. ip). After induction of diabetes, the rats swam in the exercise
groups for 12 weeks. Then, blood and tissue samples were collected.

Result:
Our results indicated a significant increase in expression levels of miR-146, NF-κB and inflammatory
cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression
levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming
exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory
cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic
group compared to the diabetic group.

Conclusion:
Our results indicated a significant increase in expression levels of miR-146, NF-κB and
inflammatory cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression
levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming
exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory
cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic
group compared to the diabetic group.
A Chatbot-Based Coaching Intervention for Adolescents to Promote Life Skills: Pilot Study
Authors: Gabrielli Silvia , Rizzi Silvia , Carbone Sara , Donisi Valeria 
Published: November 2019

Background
Adolescence is a challenging period, where youth face rapid changes as well as increasing socioemotional demands and threats, such as bullying and cyberbullying. Adolescent mental health and well-being can be best supported by providing effective coaching on life skills, such as coping strategies and protective factors. Interventions that take advantage of online coaching by means of chatbots, deployed on Web or mobile technology, may be a novel and more appealing way to support positive mental health for adolescents.

Objective
In this pilot study, we co-designed and conducted a formative evaluation of an online, life skills coaching, chatbot intervention, inspired by the positive technology approach, to promote mental well-being in adolescence.

Methods
We co-designed the first life skills coaching session of the CRI (for girls) and CRIS (for boys) chatbot with 20 secondary school students in a participatory design workshop. We then conducted a formative evaluation of the entire intervention—eight sessions—with a convenience sample of 21 adolescents of both genders (mean age 14.52 years). Participants engaged with the chatbot sessions over 4 weeks and filled in an anonymous user experience questionnaire at the end of each session; responses were based on a 5-point Likert scale.

Results
A majority of the adolescents found the intervention useful (16/21, 76%), easy to use (19/21, 90%), and innovative (17/21, 81%). Most of the participants (15/21, 71%) liked, in particular, the video cartoons provided by the chatbot in the coaching sessions. They also thought that a session should last only 5-10 minutes (14/21, 66%) and said they would recommend the intervention to a friend (20/21, 95%).

Conclusions
We have presented a novel and scalable self-help intervention to deliver life skills coaching to adolescents online that is appealing to this population. This intervention can support the promotion of coping skills and mental well-being among youth.
KAJIAN PERBEDAAN MINAT MEMBUAT PERENCANAAN KEUANGAN KELUARGA MENURUTTINGKAT PENDIDIKAN DAN PEKERJAAN IBU RUMAH TANGGA DI KOTA PEKANBARU
Authors: Lusiawati Lusiawati 
Published: November 2019

Penelitian ini bertujuan untuk mengetahui perbedaan minat ibu rumah tangga dalam membuat perencanaan keuangan keluarga di Pekanbaru ditinjau dari tingkat pendidikan dan pekerjaannya. Ibu rumah tangga sebagai orang yang sangat berperan dalam menyusun perencanaan keuangan keluarga sangat tepat sebagai sasaran untuk mensosialisasikan pentingnya memiliki perencanaan keuangan keluarga yang baik. Hasil penelitian ini diketahui bahwa berdasarkan tingkat pendidikan responden, ibu rumah tangga yang berpendidikan SMU ke bawah cendrung lebih berminat untuk membuat perencanaan keuangan keluarga daripada ibu rumah tangga yang berpendidikan S1 atau sarjana. Berdasarkan pekerjaan responden, Ibu rumah tangga yang bekerja cendrung lebih berminat untuk membuat perencanaan keuangan keluarga dari pada ibu rumah tangga yang tidak bekerja. Berdasarkan analisis Chi Square diperoleh hasil bahwa tidak terdapat perbedaan minat untuk membuat perencanaan keuangan keluarga antara ibu rumah tangga yang berpendidikan sarjana ke atas dengan ibu rumah tangga yang berpendidikan SMU kebawah. Sementara berdasarkan pekerjaan responden terdapat perbedaan minat untuk membuat perencanaan keuangan keluarga antara ibu rumah tangga yang bekerja dengan ibu rumah tangga yang tidak bekerja.
PENGARUH GAYA HIDUP DAN MOTIVASI BELAJAR TERHADAP PRESTASI BELAJAR MATA PELAJARAN PENDIDIKAN KEWARGANEGARAAN
Authors: Vianora Mimi 
Published: November 2019

Penelitian ini bertujuan untuk menganalisis secara empiris pengaruh gaya hidup dan motivasi belajar terhadap prestasi belajar Pendidikan Kewarganegaraan siswa SMAN 1 Kec. Salimpaung Kabupaten Tanah Datar. Jenis penelitian ini adalah penelitian kausatif. Populasi dalam penelitian ini adalah semua siswa SMAN 1 Kec. Salimpaung Kabupaten Tanah Datar. Sampel dipilih secara random sebanyak 23 siswa kelas XII. Data yang digunakan dalam penelitian adalah data primer yang berasal dari kuesioner yang disebar secara acak. Penelitian ini menggunakan analisis regresi berganda dengan software SPSS 21.
Hasil penelitian membutktikan bahwa variabel gaya hidup (X1) berpengaruh signifikan positif terhadap prestasi belajar siswa (Y). Variabel motivasi belajar (X2) tidak berpengaruh signifikan terhadap prestasi belajar siswa (Y).
Nutritional Composition of Salmonidae and Acipenseridae Fish Eggs
Authors: Kowalska-Góralska Monika , Formicki Krzysztof , Dobrzański Zbigniew , Wondołowska-Grabowska Anna , Skrzyńska Elżbieta , Korzelecka-Orkisz Agata , Nędzarek Arkadiusz , Tański Adam 
Published: November 2019

Abstract
Analysis of the physicochemical properties of fresh eggs (raw material for caviar production) of the Salmonidae [sea trout (Salmo trutta L. 1758) and rainbow trout (Oncorhynchus mykiss, Walbaum 1792)] and the acipenseridae [siberian sturgeon (Acipenser baeri Brandt, 1869)], as well as sturgeon hybrids (Acipenser baeri Brandt, 1869 × Acipenser gueldenstaedti Brandt & Ratzeburg, 1833), included determination of basic physicochemical parameters (pH, dry weight, content of protein, fat, fiber and ash), amino acid composition and fatty acid profile. Compared to the Acipenseridae, Salmonidae eggs yielded a 22.5% higher total protein content, a 40.0% higher level of essential amino acids (EAA) and a 57.5% lower crude fat content. The sea trout eggs showed also a completely different fatty acids profile and hence values of lipid indices (lowest PUFA value – 11.72%, highest SFA value – 39.86%). The rainbow trout and sturgeon eggs had a similar fatty acid profile, and were characterized by a high nutritional and dietary value.
Effects of Supplementing Drinking Water with Mixed Herb Extract or Outdoor Access on Meat Quality Characteristics in Broiler Chickens
Authors: Skomorucha Iwona , Sosnówka-Czajka Ewa , Muchacka Renata 
Published: November 2019

Abstract
The aim of the present study was to determine the effects of supplementing drinking water with an extract of mixed herbs or housing with outdoor access on carcass traits, levels of antioxidant enzymes (SOD, CAT, GPx), reduced glutathione (GSH), malondialdehyde (MDA), and selected quality parameters of meat from broiler chickens. One-day-old Ross 308 broiler chickens were allocated to three groups: group I (control), in which birds were kept in compartments on litter and had no outdoor access; group II, in which birds were kept in compartments on litter without outdoor access and were supplemented with an extract of mixed herbs (50% Melissa officinalis L. and 50% Urtica dioica L.) at 2 ml/l of drinking water; and group III, in which birds were raised in compartments on litter and had outdoor access from day 1 of rearing. Throughout the rearing period, the broilers had free access to feed and water. On day 42, 20 birds were selected from each group, slaughtered and subjected to simplified slaughter analysis. Their breast and leg muscles were measured for pH, colour, water holding capacity (WHC) and drip loss, and analysed for the content of antioxidant enzymes (SOD, CAT, GPx), reduced glutathione (GSH), malondialdehyde (MDA) and fatty acids. The outdoor access reduced dressing percentage, both with (P≤0.01) and without giblets (P≤0.05). The supplementation of drinking water with the mixed herb extract (2 ml/l) improved the muscle antioxidant status (higher SOD, CAT and GSH content) and reduced lipid peroxidation in the leg muscles of the broilers (lower MDA level). In general, the supplementation of the diet with the mixture of herbs in the applied form and concentration, as well as the outdoor access had no effect on the other examined quality parameters of broiler meat.
Two Approaches to Examine the Impact of Different Credit Default Indicators on Real Estate Loans
Authors: Pfalz Reimar 
Published: November 2019

Abstract
Financing of real estates was a trigger of the largest financial crisis after the “Great Depression” from the early thirties in the last century. One of the main causes of this 2007 crisis was poor risk management in real estate financing. The aim of this paper is to examine the impact of different classes of indicators on credit default rates of real estate loans. Two research approaches should confirm a model that proves how strong the relationship is between different predictor variables such as interest rates, macroeconomic and individual indicators on the response variable of credit defaults. The first approach focuses on conducting descriptive and inferential experimental research by collecting secondary data in different markets and by analysing these data for correlations and linear regressions. The second approach is an expert survey of different banks to compare and complement the results of the first research approach. The research provides the evidence that individual indicators and macroeconomic indicators have a higher impact on credit defaults than interest rates. The scientific research on this theme has led to nearly the same results in different markets: the unemployment rate and thus personal conditions are the most responsible predictors for the credit defaults, also in different markets. The novelty of the present research is the proof that a banking survey with primary data on the causes of credit defaults confirms and complements the results of the secondary data analysis.
Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells
Authors: Riabovol Olena O. , Tsymbal Dariia O. , Minchenko Dmytro O. , Lebid-Biletska Kateryna M. , Sliusar Myroslava Y. , Rudnytska Olha V. , Minchenko Oleksandr H. 
Published: November 2019

Abstract

Objective. The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1) for evaluation of their possible significance in the control of glioma growth through endoplasmic reticulum stress signaling mediated by IRE1 and glucose deprivation.

Methods. The expression of NR3C1, NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3 genes in U87 glioma cells transfected by empty vector pcDNA3.1 (control cells) and cells without ERN1 signaling enzyme function (transfected by dnERN1) under glucose deprivation was studied by real time quantitative polymerase chain reaction.

Results. It was shown that the expression level of NR3C2, AHR, SGK1, SGK3, and NNT genes was up-regulated in control U87 glioma cells under glucose deprivation condition in comparison with the control cells growing with glucose. At the same time, the expression of NRIP1 gene is down-regulated in these glioma cells under glucose deprivation, but NR3C1 and ARHGAP35 genes was resistant to this experimental condition. We also showed that inhibition of ERN1 signaling enzyme function significantly modified the response of most studied gene expressions to glucose deprivation condition. Thus, effect of glucose deprivation on the expression level of NR3C2, AHR, and SGK1 genes was significantly stronger in ERN1 knockdown U87 glioma cells since the expression of NNT gene was resistant to glucose deprivation condition. Moreover, the inhibition of ERN1 enzymatic activities in U87 glioma cells led to up-regulation of ARHGAP35 gene expression and significant down-regulation of the expression of SGK3 gene in response to glucose deprivation condition.

Conclusions. Results of this study demonstrated that glucose deprivation did not change the expression level of NR3C1 gene but it significantly affected the expression of NR3C2, AHR, NRIP, SGK1, SGK3, and NNT genes in vector-transfected U87 glioma cells in gene specific manner and possibly contributed to the control of glioma growth since the expression of most studied genes in glucose deprivation condition was significantly dependent on the functional activity of IRE1 signaling enzyme.
The coexistence of infundibular pituicytoma and Cushing’s disease due to pituitary adenoma: A case report
Authors: Gezer Emre , Selek Alev , Cetinarslan Berrin , Canturk Zeynep , Tarkun Ilhan , Ceylan Savaş 
Published: November 2019

Abstract

Objectives. Pituicytomas are rare, solid, well-circumscribed, low grade (grade I), non-neuroendocrine, and noninfiltrative tumors of the neurohypophysis or infundibulum, which appear in the sellar/suprasellar regions. Herein, we present a case with Cushing’s disease (CD) caused by an ACTH-secreting pituitary adenoma in association with an infundibular pituicytoma.

Subject and Results. A 37-year-old male patient presented to the hospital with a six-month history of blurry vision. Physical examination demonstrated plethora, excessive sweating, weight gain, moon facies, and acne. Basal serum cortisol and ACTH levels were 16 µg/dl and 32 pg/ml, respectively. The results of screening tests were suggestive of Cushing syndrome. It was also 1.97 µg/dl following 8 mg dexamethasone suppression test which was consistent with CD. Pituitary MR imaging revealed a single lesion measuring 6x6.5 mm on the pituitary stalk. Infundibular mass excision and pituitary exploration by extended endoscopic endonasal approach were applied. On immunohistochemistry, strong diffuse immunolabeling for both S100 and TTF-1 was noted for the cells of infundibular mass, diagnosed as pituicytoma. Because the developed panhypopituitarism postoperatively, patient was discharged with daily desmopressin, levothyroxine, hydrocortisone, and intramuscular testosterone, once a month.

Conclusions. Pituicytoma is an uncommon noninvasive tumor of the sellar and suprasellar regions. In this case report, we described a patient with Cushing’s disease to whom MRI displayed only an infundibular well-circumscribed lesion, but not any pituitary adenoma. Despite the absence of any sellar lesion, awareness of other undetected possible lesion and exploring hypophysis during the transsphenoidal surgery is mandatory for the correct diagnosis.
The bone hormones and their potential effects on glucose and energy metabolism
Authors: Addai Daniel , Zarkos Jacqueline , Tolekova Anna 
Published: November 2019

Abstract
The bones form the framework of our body. We know that bones protect our vital organs, regulate calcium and phosphorous homeostasis, and function as a site of erythropoiesis. More recently, however, the identification of bone hormones has allowed us to envision bones as endocrine organs too. Within the last few years, the bone hormones osteocalcin and lipocalin 2 have been implicated with glucose and energy metabolism. We systematically reviewed articles surrounding this subject and found a clear relationship between the osteocalcin levels and glucose tolerance and insulin sensitivity. We also found that many journals have shown the detrimental effects of an absences of lipocalin 2 from adipocytes. As osteocalcin administration to mice showed decreased blood glucose levels and promoted glucose tolerance and insulin sensitivity. Future studies could perhaps explore the use of osteocalcin as a supplement for type 2 diabetes.
Tree testing and estimation of heritability using the pedunculate oak Quercus robur L. seed orchard in the Krotoszyn Forest District
Authors: Barzdajn Władysław , Bruder Maciej 
Published: November 2019

Abstract
In this paper, we present the results and analyse of tree height measurements, phenological observations (bud flushing), oak powdery mildew symptoms and multiple shoots of pedunculate oaks Quercus robur L. at the age of 12 years. The examined oaks belonged to 29 open pollination families. Family as well as individual heritability scored very highly for their respective indices. The calculated indices were 0.83 for tree height, 0.98 for flushing of buds, 0.53 for oak powdery mildew symptoms and 0.58 for the multi-stem index. Family seed orchards established using a completely randomized design are not a reliable substitute for progeny testing, because of the commonly small number of collected families.
Evaluation of long term forest fires in India with respect to state administrative boundary, forest category of LULC and future climate change scenario: A Geospatial Perspective
Authors: Ahmad Firoz , Uddin Meraj , Goparaju Laxmi 
Published: November 2019

AbstractAnalysing the forest fires events in climate change scenario is essential for protecting the forest from further degradation. Geospatial technology is one of the advanced tools that has enormous capacity to evaluate the number of data sets simultaneously and to analyse the hidden relationships and trends. This study has evaluated the long term forest fire events with respect to India’s state boundary, its seasonal monthly trend, all forest categories of LULC and future climate anomalies datasets over the Indian region. Furthermore, the spatial analysis revealed the trend and their relationship.The state wise evaluation of forest fire events reflects that the state of Mizoram has the highest forest fire frequency percentage (11.33%) followed by Chhattisgarh (9.39%), Orissa (9.18%), Madhya Pradesh (8.56%), Assam (8.45%), Maharashtra (7.35%), Manipur (6.94%), Andhra Pradesh (5.49%), Meghalaya (4.86%) and Telangana (4.23%) when compared to the total country’s forest fire counts. The various LULC categories which represent the forest show some notable forest fire trends. The category ‘Deciduous Broadleaf Forest’ retain the highest fire frequency equivalent to 38.1% followed by ‘Mixed Forest’ (25.6%), ‘Evergreen Broadleaf Forest’ (16.5%), ‘Deciduous Needle leaf Forest’ (11.5%), ‘Shrub land’ (5.5%), ‘Evergreen Needle leaf Forest’ (1.5%) and ‘Plantations’ (1.2%). Monthly seasonal variation of forest fire events reveal the highest forest fire frequency percentage in the month of ‘March’ (55.4%) followed by ‘April’ (28.2%), ‘February’ (8.1%), ‘May’ (6.7%), ‘June’ (0.9%) and ‘January’ (0.7%). The evaluation of future climate data for the year 2030 shows significant increase in forest fire seasonal temperature and abrupt annual rainfall pattern; therefore, future forest fires will be more intensified in large parts of India, whereas it will be more crucial for some of the states such as Orissa, Chhattisgarh, Mizoram, Assam and in the lower Sivalik range of Himalaya. The deciduous forests will further degrade in future.The highlight/results of this study have very high importance because such spatial relationship among the various datasets is analysed at the country level in view of the future climate scenario. Such analysis gives insight to the policymakers to make sustainable future plans for prioritization of the various state forests suffering from forest fire keeping in mind the future climate change scenario.