bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strengths use at work: Positive and negative emotions as key processes explaining work performance
Authors: Dubreuil Philippe , Ben Mansour Jamal , Forest Jacques , Courcy François , Fernet Claude 
Published: November 2020

AbstractStrengths use has been frequently associated with work performance. However, the psychological processes involved in this relation remain unclear. Drawing on the Broaden‐and‐Build theory of positive emotions and extending previous work on this topic, the objective of this study was to examine the mediator role of positive and negative emotions in the relation between strengths use and work performance. Results confirm previous findings regarding positive emotions, but further reveal that negative emotions also play a significant role in this relation. Taken together, these results suggest that strengths use in the workplace not only contributes to positive emotions, but also reduces the occurrence of negative emotions, which in turn promotes work performance. Implications for research and employee management are discussed.
Positive impact of the Patient Protection and Affordable Care Act Medicaid expansion on Louisiana women with breast cancer
Authors: Chu Quyen D. , Li Tingting , Hsieh Mei‐Chin , Yi Yong , Gibbs John F. , Lyons John M. , Wu Xiao‐Cheng 
Published: November 2020

BackgroundLouisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a positive impact for Louisiana women diagnosed with breast cancer.MethodsData from the Louisiana Tumor Registry regarding 14,640 women aged 20 to 64 years who resided in Louisiana and were diagnosed with American Joint Committee on Cancer stage 0 to stage IV breast cancer between 2012 and 2018 were analyzed. The study period was divided into 2 groups: 1) before ACA expansion (January 1, 2012–May 31, 2016); and 2) after ACA expansion (June 1, 2016–December 31, 2018). The chi‐square test and multivariable logistic regression models were used to assess the impact of ACA expansion. A P value <.05 was considered statistically significant.ResultsAfter ACA expansion, the rate of uninsured patients decreased from 5.4% to 3.0% (P < .0001), and the rate of Medicaid recipients increased from 11.6% to 17.7% (P < .0001). The diagnosis of stage I breast cancer increased from 36.8% to 44.7% (P < .0001), whereas the diagnosis of stage III breast cancer decreased from 10.7% to 8.5% (P < .0001). The receipt of radiotherapy after breast‐conserving surgery increased from 81.2% to 84.0% (P = .0035), and the receipt of radiotherapy within 90 days increased from 57.2% to 61.7% (P = .0012). After adjustment for sociodemographic and clinical variables, the models demonstrated that ACA expansion decreased the uninsured rate by 48% (odds ratio [OR], 0.52; 95% CI, 0.43‐0.63), increased the diagnosis of early‐stage disease (stage0 to stage II) by 27% (OR, 1.27; 95% CI, 1.15‐1.41), increased receipt of radiotherapy after breast‐conserving surgery by 19% (OR, 1.19; 95% CI, 1.03‐1.37), and reduced the delay of receipt of radiotherapy by 16% (OR, 0.84; 95% CI, 0.74‐0.95).ConclusionsACA expansion in Louisiana reduced the uninsured rate, increased the diagnosis of early‐stage disease, and increased access to treatment.
Determinants of p16/Ki‐67 adequacy and positivity in HPV‐positive women from a screening population
Authors: Benevolo Maria , Mancuso Pamela , Allia Elena , Gustinucci Daniela , Bulletti Simonetta , Cesarini Elena , Carozzi Francesca Maria , Confortini Massimo , Bisanzi Simonetta , Rubino Teresa , Rollo Francesca , Marchi Natalina , Farruggio Angelo , Pusiol Teresa , Venturelli Francesco , Giorgi Rossi Paolo ,   for the New Technologies for Cervical Cancer 2 (NTCC2) Working Group
Published: November 2020

BackgroundThe objective of this study was to describe the determinants of adequacy and positivity of the p16/Ki‐67 assay in a human papillomavirus (HPV)‐positive screening population enrolled within the New Technologies for Cervical Cancer 2 (NTCC2) study.MethodsThinPrep slides were immunostained for p16/Ki‐67; each slide had 3 reports from different laboratories. The authors included population‐related, sampling‐related/staining‐related, and interpretation‐related variables in the analyses. Adequacy and positivity proportions were stratified by variables of interest. Univariate and multivariate logistic models were used to identify determinants of adequacy and positivity.ResultsIn total, 3100 consecutive HPV‐positive cases were analyzed. Because every slide was interpreted by 3 centers, 9300 reports were obtained, including 905 (9.7%) that were inadequate and 2632 (28.3%) that were positive. The percentage of cases in which all 3 reports were inadequate increased with increasing age of the women and with inadequate cytology. The highest percentage of adequacy in all 3 reports and of cases with all 3 reports positive was observed in specimens from women who had grade ≥2 cervical intraepithelial neoplasia (CIN2+), atypical squamous cells of undetermined significance or more severe (ASC‐US+) cytology, or mRNA positivity. The number of inadequate reports was significantly associated with increasing age, inadequate cytology, mRNA negativity, and scant cellularity. A positive p16/Ki‐67 report was associated with an ASC‐US+ result and with a positive mRNA result in cases both with and without CIN2+ but was associated with an HPV type 16 and/or 18 infection only in CIN2+ cases. The presence of CIN2+ was strongly associated with dual staining positivity.ConclusionsThe interpretation of p16/Ki‐67 results may be influenced by several different variables, all of which are part of the steps in the procedure, and by the characteristics of the screened population.
A Mouse Model of Sublethal Leptospirosis: Protocols for Infection with Leptospira Through Natural Transmission Routes, for Monitoring Clinical and Molecular Scores of Disease, and for Evaluation of the Host Immune Response
Authors: Nair Nisha , Gomes‐Solecki Maria 
Published: November 2020

AbstractLeptospirosis is a zoonotic disease caused by pathogenic Leptospira species that are maintained in sylvatic and domestic environments by transmission among rodents and other carriers. Humans become infected after contact of breached skin or mucosa with contaminated water or soil. Understanding persistent or sublethal infection in a host is critical for controlling human risk of exposure to pathogenic Leptospira. Animal models that recapitulate disease progression after infection via natural transmission routes are more appropriate for validation of vaccines and therapeutics. Furthermore, the ability to measure shedding of live Leptospira in urine of reservoir and carrier hosts can be used to develop new diagnostic assays and sensors to evaluate human risk of exposure. We developed inbred mouse models of Leptospirosis, that bypass survival as a criterion, in which we can analyze both pathogen and host factors affecting sublethal infection (<1 month), including shedding of Leptospira in urine. Mice are infected with pathogenic Leptospira using a physiologic route, and the clinical, histological, and molecular scores of disease are measured. Furthermore, the host immune response to Leptospira is evaluated. This mouse model also provides a tool in which to test fundamental hypotheses related to host‐pathogen interactions and the immune mechanisms engaged in protective and pathogenic immune responses. © 2020 Wiley Periodicals LLCBasic Protocol 1: Culture and maintenance of virulent LeptospiraBasic Protocol 2: Infection of mice through a physiologic route and collection of clinical scores and biological samplesBasic Protocol 3: Analysis of pathogenesis after Leptospira infection
Psychodynamic psychotherapy is associated with sustained reduction in health care utilization and cost
Authors: Yonatan‐Leus Refael , Strauss Asher Y. , Cooper‐Kazaz Rena 
Published: November 2020

AbstractOur objective was to examine the effectiveness and efficiency of psychodynamic psychotherapy on the reduction in health care utilization and cost while controlling for age, gender, and year. Health care utilization and cost were examined yearly in 1,675 patients from 2 years before outpatient psychotherapy (i.e., baseline) to three consecutive years after psychotherapy in a naturalistic longitudinal design. A multilevel analytic approach (LMLM) was applied to account for repeated measures effect and missing data. In the year prior to psychotherapy, there was a significant increase in total cost compared with baseline (14.8%) and in use of health care services (primary and specialist doctors' visits and outsourced referrals). In the first year following therapy, there was a significant decrease in total cost (10%) and in use of health care services (all doctors' visits, imaging, and outsourced referrals). The decrease was to baseline levels or lower and was maintained for two additional years. Psychiatric medication usage increased significantly after psychotherapy and remained so. The overall cumulative decrease in total cost per patient over 3 years after therapy was 3,665.92 NIS, equalling a 69% average cost of psychotherapy. Further cost saving can be expected due to the reduction in sick leave, disability, and psychiatric hospitalization. These findings support the notion that providing outpatient psychodynamic psychotherapy can be financially beneficial to health care systems, although further research is required for causal inferences. Also, an increase in health care utilization along with scarce physical findings may indicate unaddressed psychological distress and warrant referral for mental assessment and possible psychotherapy.
The efficacy of internet‐based cognitive behavioural therapy for social anxiety disorder: A systematic review and meta‐analysis
Authors: Guo Shangyu , Deng Wenrui , Wang Hongtao , Liu Jiayuan , Liu Xiaoyu , Yang Xinxin , He Cengceng , Zhang Qiqi , Liu Boya , Dong Xinghua , Yang Zifan , Li Ziqi , Li Xiaoming 
Published: November 2020

AbstractSocial anxiety disorder (SAD) is one of the most common lifelong anxiety disorders. Although cognitive behavioural therapy (CBT) has proven to be effective in treating people with SAD, it may not be available for a considerable proportion of patients. Internet‐based CBT (ICBT) is more accessible than face‐to‐face treatment. This meta‐analysis evaluated the efficacy of ICBT in patients with SAD. We searched five databases, PubMed, Cochrane Central Register of Controlled Trials, Health Management Information Consortium, Ovid MEDLINE and EMBASE, and identified 20 eligible randomized controlled trials published from inception to 25 July 2020, with the outcome data from 1,743 participants. The results indicated that ICBT had a significant positive effect on patients with SAD compared with the control groups (g = −0.55). A subgroup analysis revealed that ICBT and CBT had an equal effect on treating patients with SAD (g = −0.18). There was also no difference between ICBT and ICBT plus other therapies in the treatment of patients with SAD (g = −0.07). The effect size of ICBT on patients with SAD was maintained at the 6‐month follow‐up (g = −0.08) and at the 12‐month follow‐up (g = −0.17). The findings of this review demonstrated that ICBT can significantly reduce SAD symptoms and that ICBT and face‐to‐face CBT produce equivalent effects. The results of this meta‐analysis contributed to the literature on ICBT for the treatment of patients with SAD, although numerous aspects of ICBT were identified for future investigations.
Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat
Authors: Kirby Brian J. , Lutz Justin D. , Yue Mun Sang , Garrison Kimberly L. , Qin Ann Ran‐Ran , Ampaw Lorraine , Beysen Carine , Myers Robert P. , Kearney Brian P. , Mathias Anita 
Published: November 2020

Firsocostat (FIR: previously GS‐0976), a highly sensitive OATP substrate, reduces hepatic de novo lipogenesis (DNL) by inhibiting acetyl‐CoA carboxylases (ACC). Measuring the pharmacodynamic (PD) efficacy of FIR on DNL provides a unique opportunity to determine optimal dosing strategies for liver‐targeted OATP substrates in settings of altered OATP function. A randomized, four‐way crossover drug‐drug interaction study was conducted. Hepatic DNL, a marker for ACC activity, was measured in 28 healthy volunteers after reference, single dose FIR 10 mg, FIR 10 mg plus the OATP inhibitor rifampin (RIF) 300 mg i.v., or RIF 300 mg i.v. (control for DNL effect of RIF), each separated by a 7‐day washout. Samples were collected for pharmacokinetic (PK) and PD assessments through 24 hours after each treatment. Hepatic DNL and its inhibition by FIR were assessed. Twenty‐four subjects completed the study. All adverse events were mild. RIF alone increased hepatic DNL area under the effect curve from time of administration up to the time of the last quantifiable concentration (AUEClast; 35.7%). Despite a 5.2‐fold increase in FIR plasma exposure (area under the concentration‐time curve from zero to infinity (AUCinf)) when administered with RIF, FIR alone, and FIR + RIF had the same hepatic PD effect, 37.1% and 34.9% reduction in DNL AUEClast, respectively, compared with their respective controls. These findings indicate that large decreases in OATP activity do not alter hepatic intracellular exposure (as inferred by no change in PD) for drugs that are primarily eliminated hepatically and permeability rate‐limited, such as FIR. These results support PK theory that has been difficult to test and provide practical guidance on administration of liver‐targeted drugs in settings of reduced OATP function.
High‐risk human papilloma virus was not detected in a Norwegian cohort of oral squamous cell carcinoma of the mobile tongue
Authors: Søland Tine M. , Bjerkli Inger‐Heidi , Georgsen Jeanette B. , Schreurs Olaf , Jebsen Peter , Laurvik Helene , Sapkota Dipak 
Published: November 2020

AbstractObjectivesThe presence of and the causative role of high‐risk human papilloma virus (HPV) is a subject of controversy in oral squamous cell carcinoma (OSCC). The disagreement can be related to the misclassification of OSCC as oropharyngeal squamous cell carcinoma and/or lack of standard detection methods. This study aimed to examine the presence of transcriptionally active high‐risk HPV in a homogenous Norwegian cohort of primary and second primary OSCC of the mobile tongue (oral tongue squamous cell carcinoma—OTSCC).MethodsTissue microarrays containing formalin‐fixed and paraffin‐embedded cores of 146 OTSCC from the anterior 2/3 of the tongue (n = 128 primary and n = 18 second primary) from a multicentric Norwegian cohort were examined for the presence of high‐risk HPV by DNA‐ and RNA‐in situ hybridization (ISH) assays and p16 immunohistochemistry.ResultsTranscriptionally active HPV (E6/E7 mRNA) was not identified in any of the OTSCC specimens. In parallel, no tumors were positive for HPV by DNA ISH. Although, 61 (42%) OTSCC demonstrated p16 positivity with varying staining intensity and subcellular localization, only two cases demonstrated strong and uniform p16‐staining (both cytoplasmic and nuclear) in >70% of cancer cells. The absence of transcriptionally active high‐risk HPV in this cohort of OTSCC indicates that high‐risk HPV is an unlikely causative factor in the present material.
The effect of managerial ability on corporate social responsibility and firm value in the energy industry
Authors: Gong Yujing , Yan Cheng , Ho Kung‐Cheng 
Published: November 2020

AbstractWe investigate the role of managerial ability in the relationship between corporate social responsibility (CSR) and firm performance in the energy industry, where sustainability issues are of special interest. We first identify a positive association between CSR and firm value, which, however, disappears when considering managerial ability. Only the MA‐associated components of CSR increases energy firms' value. Finally, managers with superior ability can still efficiently implement CSR activities to foster firm value during the financial crisis. Taken together, these results suggest that higher managerial ability is a crucial certification of the benefit of CSR investment, which in turn improves firm value, particularly during unstable periods.
The interplay among green brand knowledge, expected eudaimonic well‐being and environmental consciousness on green brand purchase intention
Authors: Zhou Zhimin , Zheng Fucheng , Lin Jialing , Zhou Nan 
Published: November 2020

AbstractBuilding on a novel perspective of expected eudaimonic well‐being, this study investigates how green brand knowledge affects green brand purchase intention. In addition, the influences of two mediating variables (expected self‐acceptance and expected social contribution) and a moderating variable (environmental consciousness) on this process are examined. The proposed model is tested by using structural equation modelling with a sample of 529 Chinese respondents. The results indicate that green brand knowledge directly affects green brand purchase intention and indirectly influences green brand purchase intention via expected self‐acceptance and social contribution. Moreover, environmental consciousness significantly moderates the relationship between green brand knowledge and expected social contribution. These findings offer practical insights for managers in developing effective marketing strategies to enhance consumers' green brand purchase intention.
Evaluating the Cytometric Detection and Enumeration of the Wine Bacterium, Oenococcus oeni
Authors: Bartle Louise , Mitchell James G. , Paterson James S. 
Published: November 2020

AbstractFlow cytometry is a high‐throughput tool for determining microbial abundance in a range of medical, environmental, and food‐related samples. For wine, determining the abundance of Saccharomyces cerevisiae is well‐defined and reliable. However, for the most common wine bacterium, Oenococcus oeni, using flow cytometry to determine cell concentration poses some challenges. O. oeni most often occurs in doublets or chains of varying lengths that can be greater than seven cells. This wine bacterium is also small, at 0.2–0.6 μm and may exhibit a range of morphologies including binary fission and aggregated complexes. This work demonstrates a straightforward approach to determining the suitability of flow cytometry for the chain‐forming bacteria, O. oeni, and considerations when using flow cytometry for the enumeration of small microorganisms (<0.5 μm). © 2020 International Society for Advancement of Cytometry
A Bayesian Dirichlet process community occupancy model to estimate community structure and species similarity
Authors: Sollmann Rahel , Eaton Mitchell Joseph , Link William A. , Mulondo Paul , Ayebare Samuel , Prinsloo Sarah , Plumptre Andrew J. , Johnson Devin S. 
Published: November 2020

AbstractCommunity occupancy models estimate species‐specific parameters while sharing information across species by treating parameters as sampled from a common distribution. When communities consist of discrete groups, shrinkage of estimates toward the community mean can mask differences among groups. Infinite‐mixture models using a Dirichlet process (DP) distribution, in which the number of latent groups is estimated from the data, have been proposed as a solution. In addition to community structure, these models estimate species similarity, which allows testing hypotheses about whether traits drive species response to environmental conditions. We develop a community occupancy model (COM) using a DP distribution to model species‐level parameters. Because clustering algorithms are sensitive to dimensionality and distinctiveness of clusters, we conducted a simulation study to explore performance of the DP‐COM with different dimensions (i.e., different numbers of model parameters with species‐level DP random effects) and under varying cluster differences. Because the DP‐COM is computationally expensive, we compared its estimates to a COM with a normal random species effect. We further applied the DP‐COM model to a bird data set from Uganda. Estimates of the number of clusters and species cluster identity improved with increasing difference among clusters and increasing dimensions of the DP; but the number of clusters was always overestimated. Estimates of number of sites occupied and species and community‐level covariate coefficients on occupancy probability were generally unbiased with (near‐) nominal 95% Bayesian Credible Interval coverage. Accuracy of estimates from the normal and the DP‐COM was similar. The DP‐COM clustered 166 bird species into 27 clusters regarding their affiliation with open or woodland habitat and distance to oil wells. Estimates of covariate coefficients were similar between a normal and the DP‐COM. Except sunbirds, species within a family were not more similar in their response to these covariates than the overall community. Given that estimates were consistent between the normal and the DP‐COM, and considering the computational burden for the DP models, we recommend using the DP‐COM only when the analysis focuses on community structure and species similarity, as these quantities can only be obtained under the DP‐COM.
Landscape‐scale differences among cities alter common species’ responses to urbanization
Authors: Fidino Mason , Gallo Travis , Lehrer Elizabeth W. , Murray Maureen H. , Kay Cria A. M. , Sander Heather A. , MacDougall Brandon , Salsbury Carmen M. , Ryan Travis J. , Angstmann Julia L. , Amy Belaire J. , Dugelby Barbara , Schell Christopher J. , Stankowich Theodore , Amaya Max , Drake David , Hursh Sheryl H. , Ahlers Adam A. , Williamson Jacque , Hartley Laurel M. , Zellmer Amanda J. , Simon Kelly , Magle Seth B. 
Published: November 2020

AbstractUnderstanding how biodiversity responds to urbanization is challenging, due in part to the single‐city focus of most urban ecological research. Here, we delineate continent‐scale patterns in urban species assemblages by leveraging data from a multi‐city camera trap survey and quantify how differences in greenspace availability and average housing density among 10 North American cities relate to the distribution of eight widespread North American mammals. To do so, we deployed camera traps at 569 sites across these ten cities between 18 June and 14 August. Most data came from 2017, though some cities contributed 2016 or 2018 data if it was available. We found that the magnitude and direction of most species' responses to urbanization within a city were associated with landscape‐scale differences among cities. For example, eastern gray squirrel (Sciurus carolinensis), fox squirrel (Sciurus niger), and red fox (Vulpes vulpes) responses to urbanization changed from negative to positive once the proportion of green space within a city was >~20%. Likewise, raccoon (Procyon lotor) and Virginia opossum (Didelphis virginiana) responses to urbanization changed from positive to negative once the average housing density of a city exceeded about 700 housing units/km2. We also found that local species richness within cities consistently declined with urbanization in only the more densely developed cities (>~700 housing units/km2). Given our results, it may therefore be possible to design cities to better support biodiversity and reduce the negative influence of urbanization on wildlife by, for example, increasing the amount of green space within a city. Additionally, it may be most important for densely populated cities to find innovative solutions to bolster wildlife resilience because they were the most likely to observe diversity losses of common urban species.