bluuebunny/crossref_metadata_2025_split huggingface dataset:
Дексмедетомидин как адъювант к бупивакаину при спинальной анестезии для артропластики тазобедренного сустава
Authors: Kolomachenko V.I. , Fesenko V.S. 
Published: December 2020

Актуальность. Спинальная анестезия является экономически эффективным методом для хирургии нижних конечностей. Один из ее недостатков — небольшая длительность послеоперационной аналгезии. Цель исследования: ­выявить эффект от добавления 5 или 10 мкг дексмедетомидина к 12 мг бупивакаина на характеристики блока у пациентов, подвергающихся артропластике тазобедренного сустава. Материалы и методы. 45 пациентов были случайным образом разделены на три группы (по 15 в каждой): Б — введение лишь бупивакаина, БД5 — бупивакаин и 5 мкг дексмедетомидина и БД10 — бупивакаин и 10 мкг дексмедетомидина. Перед операцией и после нее оценивался моторный блок по модифицированной шкале Bromage. После операции также регистрировалось время до первой потребности в системной аналгезии. Результаты. Перед операцией время наступления полного моторного блока (Me [25 %; 75 %]) в группе БД10 (6,5 [5,0; 10] минуты) было незначительно меньше, чем в группах БД5 (10,0 [7,0; 15,0] минуты; p = 0,35) и Б (13,5 [10,0; 15,0] минуты; p = 0,08). После операции время частичного исчезновения моторного блока в группе БД10 (540 [360; 660] минут) было значительно (p < 0,001) большим, чем в группах БД5 (330 [300; 420] минут) и Б (200 [190; 240] минут); различие между группами БД10 и БД5 также было большим (p = 0,015). Время до полного исчезновения моторного блока в группе БД10 (630 [420; 720] минут) было значительно (p < 0,001) большим, чем в группах БД5 (380 [340; 460] минут) и Б (255 [210; 280] минут); различие между группами БД10 и БД5 также было большим (p = 0,008). В послеоперационном периоде время до первой потребности в системной аналгезии в группе БД10 было большим (720 [600; 860] минут), чем в группах БД5 (450 [400; 540] минут; p = 0,0014) и Б (285 [230; 300] минут; p < 0,001); в группе БД5 время до первой потребности системной аналгезии было большим, чем в группе Б (p < 0,001). Выводы. Добавление дексмедетомидина удлиняет как моторный блок, так и аналгезию от спинальной анестезии.
Iracema: a Python library for audio content analysis
Authors: Magalhaes Tairone Nunes , Barros Felippe Brandão , Loureiro Mauricio Alves 
Published: December 2020

Iracema is a Python library that aims to provide models for the extraction of meaningful informationfrom recordings of monophonic pieces of music, for purposes of research in music performance. With this objective in mind, we propose an architecture that will provide to users an abstraction level that simplifies the manipulation of different kinds of time series, as well as the extraction of segments from them. In this paper we: (1) introduce some key concepts at the core of the proposed architecture; (2) describe the current functionalities of the package; (3) give some examples of the application programming interface; and (4) give some brief examples of audio analysis using the system.
Exposição colecionismo: relações entre curadoria e mercado da arte
Authors: Quaiatto Rittieli D'Avila , Lima Andrea Capssa de 
Published: December 2020

Este artigo no campo da História, Teoria e Crítica da Arte contribui para pensar as relações entre a curadoria e o mercado da arte, com análise crítica de estratégias expositivas utilizadas em galerias comerciais. Por meio dos conceitos e práticas curatoriais da exposição “Colecionismo”, realizada na Moblanc Galeria em 2019, na qual obras de artistas expoentes da História da Arte convergem com produções contemporâneas de artistas representados pela galeria, compreende-se, no sistema da arte, as dinâmicas voltadas para o colecionismo e o investimento em arte, com base na legitimação e visibilidade. AbstractThis article in the field of History, Theory and Criticism of Art contributes to think about the relationship between curatorship and the art market, with a critical analysis of exhibition strategies used in art galleries. Through the curatorial concepts and practices of the exhibition “Colecionismo”, held in 2019, in which works by artists who are exponents of Art History converge with contemporary productions by artists represented by the gallery, in the art system, it is understood dynamics focused on collecting and investing in art, based on legitimation and visibility.
No inferioridad entre dos agentes de bajo volumen (Picosulfato de Sodio/Citrato de Magnesio vs. Sulfato de Sodio/Potasio/Magnesio) en la preparación de colon para procedimientos diagnósticos: estudio observacional
Authors: Pérez-Riveros Erika D. , Rey R. Margarita , Mendoza De Molano Belén , Robayo Juan Carlos , Solano Mariño Jaime , García Duperly Rafael , Gómez Andrés , Pinto Carta Renzo , Ardila Gerardo , De la Hoz-Valle Jose , Sierra-Arango Fernando 
Published: December 2020

Introducción: el cáncer colorrectal es un problema de salud pública; sin embargo, la detección temprana reduce su morbimortalidad. La colonoscopia es el procedimiento de elección para detectar lesiones premalignas y el éxito depende de una limpieza adecuada. El objetivo es evaluar el desempeño de dos preparaciones de bajo volumen empleados en un hospital de alto nivel.
Materiales y métodos: estudio prospectivo en adultos que asistieran a colonoscopia en la Fundación Santa Fe de Bogotá, Colombia. Las preparaciones se evaluaron con la escala de Boston, con puntaje ≥ 6 puntos para una limpieza adecuada. Se realizó un análisis de regresión logística para establecer la efectividad de los medicamentos con un cálculo de no inferioridad del 3 %-5 %.
Resultados: 598 pacientes fueron evaluados. El 49 % (293) fue expuesto al picosulfato de sodio/citrato de magnesio y el 51 % (305) fue expuesto al sulfato de sodio/potasio/magnesio. Con un promedio de Boston de 6,98 ± 1,86 (78 % con puntaje de Boston ≥ 6) y 7,39 ± 1,83 (83 %), respectivamente (p = 0,649). Según el análisis de la presencia y frecuencia de síntomas no deseados, el picosulfato fue mejor tolerado (p < 0,001).
Conclusiones: los estudios de preparación intestinal en pacientes de un escenario real son muy escasos.Los medicamentos de bajo volumen obtuvieron una efectividad global y por segmento de colon similar, confirmando la no-inferioridad; el picosulfato de sodio/citrato de magnesio fue mejor tolerado. Un estudio de costo-efectividad podría definir esto según las necesidades de la población de estudio.
Parent Perspectives on Educational and Psychosocial Intervention for Recent-Onset Type 1 Diabetes in Their School-Age Child: A Qualitative Study
Authors: Marker Arwen M. , Monzon Alexandra D. , Goggin Kathy , Clements Mark A. , Patton Susana R. 
Published: December 2020

OBJECTIVE
The recent-onset period of type 1 diabetes (T1D) in early school-age children should include comprehensive, parent-focused T1D education as well as family-centered resources and support to help with adjustment. Here, we present parent/caregiver perspectives on specific areas of concern during the recent-onset period of T1D and their preferred timing for different topics related to T1D education.

METHODS
Parents/caregivers of 5- to 9-year-old children with T1D completed a card-sorting task and qualitative interview to describe ongoing areas of concern and preferred educational topics during the first year after T1D diagnosis.

RESULTS
Thirteen parents/caregivers (aged 35.1 ± 6.9 years) of a child with T1D (aged 8.9 ± 0.8 years, 11.3 ± 7.0 months post-diagnosis) completed the card-sorting task, and 11 completed the qualitative interview. Parents/caregivers endorsed four preferred stages of education: basic education and T1D survival skills during month 1 post-diagnosis, application and practice of T1D skills from months 1–3, access to community supports to cope with anxiety and distress from months 3–6, and support to build autonomy and manage burnout beyond month 6 post-diagnosis. Parents/caregivers endorsed four main themes for ongoing concerns: anxiety, autonomy, distress, and support.

CONCLUSION
Parents endorsed four time points for education and psychosocial services within the first year of a T1D diagnosis. Parents/caregivers may benefit the most from psychosocial interventions 3–6 months post-diagnosis, once they have had sufficient time to develop basic T1D management skills. These findings support the need for regular parent psychosocial screening and access to scalable psychosocial interventions in the first year post-diagnosis of T1D.
Simulasi Model Proses Tebang Muat Angkut (TMA) On Farm pada Tanaman Tebu
Authors: Khamidatullailiyah Yayang Galuh Nur , Yaqin Muhammad Ainul , Utomo Adi Heru 
Published: December 2020

Masalah yang sering terjadi pada saat musim Tebang Muat Angkut (TMA) tebu yaitu kapasitas produksi tebu yang tidak memenuhi target produksi pabrik dan terjadinya penumpukan antrian transportasi pada proses bongkar tebu. Untuk meminimalisir terjadinya masalah pada proses TMA maka peneliti melakukan simulasi untuk menganalisa waktu yang efektif. Software yang digunakan dalam membuat simulasi TMA yaitu AnyLogic. Dalam penelitian ini, peneliti menggunakan tiga source yang merepresentasikan tebu, lahan, dan transportasi. Delay time, waktu kedatangan, dan kapasitas merupakan variabel yang akan diuji coba. Jenis waktu kedatangan yang digunakan yaitu arrival rate dan arrival schedule. Peneliti menggunakan model discrete event simulation karena simulasi ini menerapkan proses pemodelan sistem yang berkaitan dengan waktu penjadwalan. Dari percobaan yang telah dilakukan, diperoleh waktu kedatangan source tebu 1/seconds, source lahan 1/hours, dan source transportasi 1/hours. Lalu kapasitas muat dari transportasi sebesar 600 tebu. Kemudian, delay time tebang dan bundle tebu 0.5,1,1.5 seconds; muat 0.5,1,1.5 hours; angkut 2,3,4 hours; dan bongkar 0.5,1,1.5 seconds. Estimasi waktu terbaik pada simulasi menggunakan arrival rate sebesar 33.30 seconds, sedangkan pada arrival schedule estimasi waktu sebesar 33.72 seconds.
Una temprana disputa sobre la teoría social y las asociaciones
Authors: Silla Rolando 
Published: December 2020

Autor: Gabriel TardeTítulo: Monadología y sociologíaEditorial: Editorial CactusBuenos Aires, 2006Autor: Emile Durkheim.Título: El Suicidio. Estudio de sociología.Editora: Editorial Miño y DávilaBuenos Aires, 2006
Formação continuada de professores: reflexões sobre o desenvolvimento do raciocínio multiplicativo no ciclo de alfabetização
Authors: Kiss de Souza Eliane , Dorneles Beatriz Vargas , Franco Sérgio Roberto Kieling 
Published: December 2020

RESUMO: Neste artigo analisa-se a eficácia da formação continuada de professores através dos resultados de grupos experimentais A, B e grupo controle, em relação ao desempenho dos alunos do 3º ano do ensino fundamental na resolução de situações-problema com distribuição/partição e multiplicação. Para tal, foi desenvolvido para os grupos experimentais A e B um processo de formação sobre o desenvolvimento do raciocínio multiplicativo a partir dos conhecimentos prévios dos alunos, coletados na aplicação de um pré-teste. Verificou-se o efeito da formação continuada ao comparar o emprego de estratégias e o percentual de acerto dos alunos no pré-teste e nos pós-teste 1 e 2, com análise qualitativa e quantitativa. Os resultados evidenciaram que o processo de formação continuada junto ao grupo experimental B, com participação espontânea dos professores, contribuiu na construção coletiva dos saberes docentes e no desempenho dos alunos.

PALAVRAS-CHAVE: Formação Continuada de Professores. Raciocínio Multiplicativo. Desenvolvimento dos Alunos.
MENINGKATKAN KUALITAS MUTU MASYARAKAT BERBASIS TEKNOLOGI, BERBAHASA DAN BERAGAMA DEMI MENUNJANG DESA PARIWISATA YANG LEBIH PRODUKTIF
Authors: Sa’adiyah Maemunah , Jaelani Alan , Aziz Raden Muhammad Jiddan , Maulida Yola 
Published: December 2020

Sebagai salah satu bentuk daripada Tri Dharma Perguruan Tinggi, Kuliah Kerja Nyata Tematik Terintegrasi merupakan orientasiprogram yang kegiatannya terfokus pada bidang tertentu sesuai dengan permasalahan kemasyarakatan dan arah kebijakan pembangunan yang diselenggarakan pemerintah wilayah tertentu, adapun Kuliah Kerja Nyata Bertujuan untuk mencapai ekselerasi dan efektivitas program kerja pembangunan yang ditandai dengan semakin baiknya kualitas kehidupan masyarakat dan program program pembangunan. Beberapa tahap yang dilakukan dalam melakukan penelitian dan proses mengabdi ketika berlangsung dengan bermodalkan Data dan Hasil Survey yang telah dilakukan dari tanggal 6 Agustus hingga 6 September di Desa Pabangbon maka dari itu memutuskan mengunggulkan infrastruktur terutama teknologi dalam menunjang desa pariwisata yang tak luput dari Pengajaran Keagamaan dan Berbahasa Internasional. Tidak lupa Program Kerja dalam membantu masyarakat lainnya yang telah dilakukan seperti: Membuat Seminar Pendidikan Kepada Guru dan Wali Murid, Mengajar PAUD (Pendidikan Anak Usia Dini), Mengajar Diniyah, Tahsin Al-Quran, Pengajian Ratib Al-Hadad, Majelis Talim dan Doa Bersama, Pawai Obor, Tabligh Akbar, Senam Sehat, PHBS (Penyuluhan Perilaku Hidup Bersih dan Sehat) sekaligus renovasi MCK (Mandi Cuci Kakus), Penyuluhan dan Simulasi Evakuasi Gempa, Gemar Menabung Sejak Dini, Pelatihan Kewirausahaan (Produk dan Pemasaran), Seminar Pasar Modal Syariah, Kursus Komputer, Penerangan Jalan Umum berbasis Tenaga Surya, Perayaan 17 Agustus Sedesa dan Sekampung, Nobar (Nonton Bareng) Film Perjuangan, Gapura Masjid, Bakti Sosial, Kerja Bakti, Penyuluhan Hukum perkawinan dan Hukum tanah dalam aspek perdata dan pidana. Pada intinya semua Program Kerja dapat terealisasi karena ada dorongan doa dan usaha terutama Masyarakat di dalamnya, semoga apa yang telah di abdikan dapat dirasakan langsung oleh masyarakat.
MEMBANGUN MASYARAKAT DESA BANYUWANGI DALAM MENINGKATKAN SUMBER DAYA MANUSIA MENUJU DESA YANG KRATIF DAN INOVATIF
Authors: Fahri Muhammad , Riani Desmy , Murdani Dendy 
Published: December 2020

KKN Tematik Terintegrasi merupakan KKN yang orientasi program terfokus pada bidang tertentu sesuai dengan permasalahan kemasyarakatan dan arah kebijakan pembangunan yang diselenggarakan pemerintah pada wilayah tertentu (Kabupaten/Kota). KKN memiliki tujuan untuk mencapai ekselerasi dan efektivitas program pembangunan yang ditandai dengan semakin baiknya kualitas kehidupan masyarakat, partisipasi dan eksistensi masyarakat dalam program-program pembangunan. Kegiatan KKN dibagi menjadi beberapa tahap, yaitu survey dan observasi ke desa sasaran, workshop, pendekatan sasaran program, realisasi program, monitoring dan evaluasi kegiatan, dan lokakarya hasil KKN. Pelaksanaan KKN dimulai dari tanggal 7 Agustus 2019 sampai dengan 5 September 2019 di Desa Banyu Wangi Kecamatan Cigudeg Kabupaten Bogor. Program KKN kelompok 59 dan 60 di Desa Banyu Wangi merupakan program yang lebih menekankan kepada kualitas sumber daya manusia. Kegiatan fisik kelompok 59-60. yaitu pemberian dan pemasangan Gapura, Pengecatan Mushola, Penyediaan Air Bersih, Pengadaan Taman Baca dan Penerangan Jalan. Dan kegiatan non fisik kelompok 59 dan 60 antara lain pendampingan Posyandu, penyuluhan kesehatan (PHBS, CTPS dan Hipertensi disertai pemeriksaan tensi gratis), Kegiatan Mengajar di dalam Posko, SD dan MTS ,Pelatihan Microsoft Word Dan Simulasi UNBK di SMP dan SMA sederajat, kegiatan Mengaji, Bimbel, pelaksanaan kegiatan TPA, lomba 17 agustus, dan acara perpisahan KKN di Kampung dan Kantor Desa.
Sugar-Coated Killer: Serotype 3 Pneumococcal Disease
Authors: Luck Jennifer N. , Tettelin Hervé , Orihuela Carlos J. 
Published: December 2020

Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents entrapment in mucus during colonization, traps water to protect against desiccation, can serve as an energy reserve, and protects the bacterium against complement-mediated opsonization and immune cell phagocytosis. To date, 100 biochemically and serologically distinct capsule types have been identified for S. pneumoniae; 20 to 30 of which have well-defined propensity to cause opportunistic human infection. Among these, serotype 3 is perhaps the most problematic as serotype 3 infections are characterized as having severe clinical manifestations including empyema, bacteremia, cardiotoxicity, and meningitis; consequently, with a fatality rate of 30%–47%. Moreover, serotype 3 resists antibody-mediated clearance despite its inclusion in the current 13-valent conjugate vaccine formulation. This review covers the role of capsule in pneumococcal pathogenesis and the importance of serotype 3 on human disease. We discuss how serotype 3 capsule synthesis and presentation on the bacterial surface is distinct from other serotypes, the biochemical and physiological properties of this capsule type that facilitate its ability to cause disease, and why existing vaccines are unable to confer protection. We conclude with discussion of the clonal properties of serotype 3 and how these have changed since introduction of the 13-valent vaccine in 2000.
The Body Weight Alteration and Incidence of Neoplasm in Patients With Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
Authors: Lin Chu , Cai Xiaoling , Yang Wenjia , Lv Fang , Nie Lin , Ji Linong 
Published: December 2020

ObjectiveWhether hypoglycemic treatments with weight-alternating effects influence the incidence of neoplasm in type 2 diasbetes (T2D) remains uncertain. Therefore, we performed a meta-analysis to assess the association between the weight alteration and incidence of neoplasm in patients with T2D.Research Design and MethodsSystematic searches were conducted for studies published between the inception of 1950s and September 2019. Randomized controlled trials conducted in T2D patients with at least 48-week follow-up, significant weight change difference between treatment arms and reports of neoplasm events were included. Fixed-effects model and meta-regression analysis were accordingly used.ResultsIn all, 46 studies were included. Analysis indicated weight reduction was not associated with a decreased incidence of neoplasm (OR = 1.01, 95% CI, 0.96 to 1.07, I2 = 17%) and weight elevation was not associated with an increased incidence of neoplasm (OR = 0.91, 95% CI, 0.76 to 1.09, I2 = 0%). Meta-regression analysis showed a slower weight reduction rate (β = −5.983, 95% CI, −11.412 to 0.553, P = 0.03) instead of weight change difference (β = −0.030, 95% CI, −0.068 to 0.007, P = 0.115) was significantly associated with reduced risk of neoplasm in patients with T2D. Moreover, a decreased incidence of prostate, bladder, and uterine neoplasm was observed in T2D patients with weight reduction difference while an increased incidence of thyroid neoplasm was found in glucagon-like peptide-1 receptor analog (GLP-1RA) users with weight reduction difference.ConclusionsAdditional weight change achieved by current hypoglycemic agents or strategies in short and medium periods was not associated with incidence of most neoplasm in patients with T2D. However, a decreased incidence of prostate, bladder, and uterine neoplasm was shown in T2D patients with weight reduction difference while an increased risk of thyroid neoplasm was observed in T2D patients on GLP-1RA treatments with weight reduction difference. A more sustained and persistent weight reduction process may confer reduced risk of neoplasm in patients with T2D.
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma
Authors: Mou Zezhong , Yang Chen , Zhang Zheyu , Wu Siqi , Xu Chenyang , Cheng Zhang , Dai Xiyu , Chen Xinan , Ou Yuxi , Jiang Haowen 
Published: December 2020

BackgroundBladder carcinoma (BC) is one of the most prevalent and malignant tumors. Multiple gene signatures based on BC metabolism, especially regarding glycolysis, remain unclear. Thus, we developed a glycolysis-related gene signature to be used for BC prognosis prediction.MethodsTranscriptomic and clinical data were divided into a training set and a validation set after they were downloaded and analyzed from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Gene-set enrichment analysis (GSEA) and differential analysis were used to screen differentially expressed genes (DEGs), while univariate Cox regression and lasso-penalized Cox regression were employed for signature establishment. To evaluate the prognostic power of the signature, receiver operating characteristic (ROC) curve and Kaplan–Meier (KM) survival analysis were also used. Additionally, we developed a nomogram to predict patients’ survival chances using the identified prognostic gene signature. Further, gene mutation and protein expression, as well as the independence of signature genes, were also analyzed. Finally, we also performed qPCR and western blot to detect the expression and potential pathways of signature genes in BC samples.ResultsTen genes were selected for signature construction among 71 DEGs, including nine risk genes and one protection gene. KM survival analysis revealed that the high-risk group had poor survival and the low-risk group had increased survival. ROC curve analysis and the nomogram validated the accurate prediction of survival using a gene signature composed of 10 glycolysis-related genes. Western blot and qPCR analysis demonstrated that the expression trend of signature genes was basically consistent with previous results. These 10 glycolysis-related genes were independent and suitable for a signature.ConclusionOur current study indicated that we successfully built and validated a novel 10-gene glycolysis-related signature for BC prognosis.
Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway
Authors: Chen Shenglong , Tang Chaogang , Ding Hongguang , Wang Zhonghua , Liu Xinqiang , Chai Yunfei , Jiang Wenqiang , Han Yongli , Zeng Hongke 
Published: December 2020

BackgroundThe NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood–brain-barrier disruption in sepsis-associated encephalopathy (SAE). However, no information is available concerning the critical upstream regulators of SAE.MethodsLipopolysaccharide (LPS) was used to establish an in vitro model of blood–brain barrier (BBB) disruption and an in vivo model of SAE. Disruption of BBB integrity was assessed by measuring the expression levels of tight-junction proteins. NLRP3 inflammasome activation, pro-inflammatory cytokines levels, and neuroapoptosis were measured using biochemical assays. Finally, the FITC-dextran Transwell assay and Evan’s blue dye assay were used to assess the effect of Maf1 on LPS-induced endothelial permeability in vitro and in vivo.ResultsWe found that Maf1 significantly suppressed the brain inflammatory response and neuroapoptosis induced by LPS in vivo and in vitro. Notably, Maf1 downregulated activation of the NF-κB/p65-induced NLRP3 inflammasome and the expression of pro-inflammatory cytokines. In addition, we found that Maf1 and p65 directly bound to the NLRP3 gene promoter region and competitively regulated the function of NLRP3 in inflammations. Moreover, overexpression of NLRP3 reversed the effects of p65 on BBB integrity, apoptosis, and inflammation in response to LPS. Our study revealed novel role for Maf1 in regulating NF-κB-mediated inflammasome formation, which plays a prominent role in SAE.ConclusionsRegulation of Maf1 might be a therapeutic strategy for SAE and other neurodegenerative diseases associated with inflammation.