bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of lung function and lung density of young adults who had bronchopulmonary dysplasia
Authors: Santema Helger Y. , Stolk Jan , Los Mady , Stoel Berend C. , Tsonaka Roula , Merth Istvan T. 
Published: October 2020

COPD risk is jointly determined by fetal lung development, lung growth rate and lung growth duration leading to the maximally attained level of lung function in early adulthood. Bronchopulmonary dysplasia (BPD) is considered a developmental arrest of alveolarisation. Long-term outcome studies of adult survivors born before the introduction of surfactant therapy (“old BPD”) showed impaired lung function. We aimed to predict adult lung function and lung density in a cohort of premature infants born in the surfactant era, representing “new BPD”.We studied a cohort of young adults born between 1987 and 1998, with (n=36) and without (n=28) BPD, treated in a single centre. Their perinatal characteristics and pulmonary function in infancy were studied by regression analysis for correlation with adult lung function and tissue lung density, all expressed by z-scores, at a mean age of 19.7±1.1 and 21±2.2 years, respectively.Although BPD adults had on average lower forced expiratory volume in 1 s (zFEV1)/forced vital capacity (FVC) and zFEV1than those without, 55% of the BPD group had zFEV1/FVC values above the lower limit of normal (LLN). Moreover, above LLN values of diffusing capacity of the lung for carbon monoxide (zDLCO) was present in 89% of BPD adults and lung density in 71%. Only higher oxygen supply (FIO2) at 36 weeks post-conception of BPD subjects had a trend with lower zFEV1(B=−6.4; p=0.053) and lower zDLCO(B=−4.1; p=0.023) at adulthood.No statistically significant predictors of new BPD were identified.
Cost of illness of non-multidrug-resistant tuberculosis in Germany: an update
Authors: Diel Roland , Nienhaus Albert 
Published: October 2020

BackgroundA total of 5429 new cases of tuberculosis (TB) were reported in Germany in 2018; out of the 3780 TB cases for whom drug susceptibility testing was available, the proportion of multidrug-resistant TB (MDR-TB) cases was only 3.1% (118 cases).MethodsOn the basis of the current therapy guidelines of the German Central Committee against Tuberculosis, this study estimates the mean direct outpatient and combined in- and outpatient costs per non-MDR-TB patient from the perspective of the German statutory health insurance (SHI) system, together with costs arising from productivity losses and costs due to public health screening for TB in close contacts.ResultsFrom the insurance perspective, the mean outpatient costs (rounded) per case were €1628 for adults and €1179 for children for standard therapy; the mean cost of inpatient treatment amounted to €8626. The mean combined inpatient/outpatient cost was €8756 for adults and €8512 for children. As 95% of all TB patients were adults, the weighted treatment cost per patient in Germany in 2018 was €8746. These are in addition to the mean cost arising from productivity losses (€1839) and, weighted by pulmonary infectivity, cost of contact investigations (€368), coming to a total of €10 953.ConclusionGiven the clear increase in the number of non-MDR-TB cases since 2015, TB is still a disease of significant economic impact in Germany.
COVID-19 in children with underlying chronic respiratory diseases: survey results from 174 centres
Authors: Moeller Alexander , Thanikkel Leo , Duijts Liesbeth , Gaillard Erol A. , Garcia-Marcos Luis , Kantar Ahmad , Tabin Nathalie , Turner Steven , Zacharasiewicz Angela , Pijnenburg Mariëlle W.H. 
Published: October 2020

BackgroundEarly reports suggest that most children infected with severe acute respiratory syndrome coronavirus 2 (“SARS-CoV-2”) have mild symptoms. What is not known is whether children with chronic respiratory illnesses have exacerbations associated with SARS-CoV-2 virus.MethodsAn expert panel created a survey, which was circulated twice (in April and May 2020) to members of the Paediatric Assembly of the European Respiratory Society (ERS) andviathe social media of the ERS. The survey stratified patients by the following conditions: asthma, cystic fibrosis (CF), bronchopulmonary dysplasia (BPD) and other respiratory conditions.ResultsIn total 174 centres responded to at least one survey. 80 centres reported no cases, whereas 94 entered data from 945 children with coronavirus disease 2019 (COVID-19). SARS-CoV-2 was isolated from 49 children with asthma of whom 29 required no treatment, 19 needed supplemental oxygen and four children required mechanical ventilation. Of the 14 children with CF and COVID-19, 10 required no treatment and four had only minor symptoms. Among the nine children with BPD and COVID-19, two required no treatment, five required inpatient care and oxygen and two were admitted to a paediatric intensive care unit (PICU) requiring invasive ventilation. Data were available from 33 children with other conditions and SARS-CoV-2 of whom 20 required supplemental oxygen and 11 needed noninvasive or invasive ventilation.ConclusionsWithin the participating centres, in children with asthma and CF, infection with SARS-CoV-2 was well tolerated, but a substantial minority of children with BPD and other conditions required ventilatory support indicating that these latter groups are at risk from SARS-CoV-2 infection.
Association of dietary inflammatory potential with cardiometabolic risk factors and diseases: a systematic review and dose–response meta-analysis of observational studies
Authors: Aslani Zahra , Sadeghi Omid , Heidari-Beni Motahar , Zahedi Hoda , Baygi Fereshteh , Shivappa Nitin , Hébert James R. , Moradi Sajjad , Sotoudeh Gity , Asayesh Hamid , Djalalinia Shirin , Qorbani Mostafa 
Published: October 2020

Abstract
Context
The association of dietary inflammatory index (DII®), as an index of inflammatory quality of diet, with cardiometabolic diseases (CMDs) and risk factors (CMRFs) has been inconsistent in previous studies.

Objective
The current systematic review and dose–response meta-analysis was performed to investigate the association of the DII score with CMDs and CMRFs.

Data Sources
All published observational studies (cohort, case–control and cross-sectional) using PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar databases were retrieved from inception through November 2019.

Data extraction
Two reviewers independently extracted the data from included studies.

Data analysis
Pooled hazard ratio (HR) or odds ratio (OR) were calculated by using a random-effects model.

Results
Ten prospective cohort studies (total n = 291,968) with 31,069 CMDs-specific mortality, six prospective cohort studies (total n = 43,340) with 1311 CMDs-specific morbidity, two case–control studies with 2140 cases and 6246 controls and one cross-sectional study (total n = 15,613) with 1734 CMDs-specific morbidity were identified for CMDs. Meta-analyses of published observational studies demonstrated that the highest DII score category versus the lowest DII score category was associated with 29% increased risk of CMDs mortality (HR = 1.29; 95% confidence interval (CI) 1.18, 1.41). Moreover, there was a significant association between the DII score and risk of CMDs in cohort studies (HR = 1.35; 95% CI 1.13, 1.61) and non-cohort study (HR = 1.36; 95% CI 1.18, 1.57). We found a significant association between the DII score and metabolic syndrome (MetS) (OR: 1.13; 95% CI 1.03, 1.25), hyperglycemia and hypertension. None-linear dose response meta-analysis showed that there was a significant association between the DII score and risk of CMDs mortality (Pnonlinearity < 0.001). Moreover, evidence of none-linear association between the DII score and risk of CMDs was not observed (p-value = 0.1).

Conclusions
Adherence to pro-inflammatory diet was associated with increased risk of CMDs, mortality and MetS.
Triple stimulation (TriStim) before bilateral oophorectomy in a young woman with ovarian cancer: a case report and review of the literature
Authors: Gemmell Laura C. , Wright Jason D. , Brady Paula C. 
Published: October 2020

Abstract
Background
Double ovarian stimulation (DuoStim) involves two rounds of controlled ovarian stimulation (COS) and oocyte retrieval in immediate succession. It represents a promising approach to increase oocyte yield for patients with diminished ovarian reserve or those with limited time before fertility-threatening oncologic treatment. We report the case of a 31-year-old woman with Stage IC endometrioid ovarian cancer who underwent a triple stimulation or “TriStim,” completing three rounds of COS and oocyte retrieval within 42 days prior to bilateral salpingo-oophorectomy.

Case presentation
A 31 year old nulligravid woman presented for fertility preservation counseling following a bilateral ovarian cystectomy that revealed Stage IC endometroid adenocarcinoma arising within endometrioid borderline tumors. The patient was counseled for bilateral salpingo-oophorectomy, lymph node dissection, and omentectomy followed by three cycles of carboplatin/paclitaxel. Prior to this, all within six weeks, the patient underwent three rounds of controlled ovarian stimulation using an antagonist protocol and human chorionic gonadotropin (hCG) trigger, resulting in vitrification of nine two-pronuclear zygotes (2PN), after which definitive surgery was performed.

Conclusions
Advantages of DuoStim procedures are increasingly recognized, especially for oncology patients with limited time before potentially sterilizing cancer treatment. To our knowledge, this is the first report of a triple stimulation (“TriStim”). Our case highlights that triple stimulation is a viable option for patients needing urgent fertility preservation in order to maximize egg and embryo yield within a limited time period.
Common musculoskeletal impairments in postpartum runners: an international Delphi study
Authors: Christopher Shefali M. , Garcia Alessandra N. , Snodgrass Suzanne J. , Cook Chad 
Published: October 2020

AbstractBackgroundPostpartum runners report musculoskeletal pain with running. Because of inadequate research, little is known about the origin and pain-related classification. Through expert consensus, this study is the first attempt to understand the musculoskeletal impairments that these runners present with. The objective of this survey was to gather expert consensus on characteristics of reported impairments in postpartum runners that have musculoskeletal pain.MethodsA web-based Delphi survey was conducted and was composed of five categories: strength, range of motion, alignment and flexibility impairments, as well as risk factors for pain in postpartum runners.ResultsA total of 117 experts were invited. Forty-five experts completed round I and forty-one completed rounds II and III. The strength impairments that reached consensus were abdominal, hip and pelvic floor muscle weakness. The range of motion impairments that reached consensus were hip extension restriction, anterior pelvic tilt and general hypermobility. The alignment impairments that reached consensus were a Trendelenburg sign, dynamic knee valgus, lumbar lordosis, over-pronation and thoracic kyphosis. The flexibility impairments that reached consensus were abdominal wall laxity, and tightness in hip flexors, lumbar extensors, iliotibial band and hamstrings. The risk factors for pain in postpartum runners were muscular imbalance, poor lumbopelvic control, too much too soon, life stressors, pain during pregnancy and pelvic floor trauma.ConclusionThis study presents a framework for clinicians to understand pain in postpartum runners and that can be investigated in future cohort studies.Level of evidence5
BDS B1I multipath channel statistical model comparison between static and dynamic scenarios in dense urban canyon environment
Authors: Chen Xin , He Di , Pei Ling 
Published: October 2020

AbstractGlobal Navigation Satellite System (GNSS) multipath channel models are fundamental and critical for signal simulation and receiver performance evaluation. They also aid the designing of suitable multipath error mitigation algorithms when the properties of multipath channel are available. However, there is insufficient existing research on BeiDou Navigation Satellite System (BDS) signal multipath channel models. In this study, multipath channel statistical models are established on the basis of extensive datasets of the BDS B1I signal. A multipath parameter estimation algorithm is designed to extract information of multipath rays from the intermediate frequency data. The delay, power loss, Doppler fading frequency, and lifetime distribution models for static and dynamic vehicle platforms are established and compared, and the effects of the satellite orbit type and platform speed on the models are analyzed. The results reveal the detailed distribution and variation characteristics of the multipath parameters and are valuable for the development of accurate urban navigation systems.
Pitfalls in scientific research: critical appraisal of articles published in one of the international journals in Egypt
Authors: Nasr Sarah S. , Sherif Ghada M. , Ibrahim Amal S. , Allam Rasha M. 
Published: October 2020

AbstractBackgroundTo identify and report flaws of Internet-published articles in theJournal of the Egyptian National Cancer Institute(JENCI), Cairo University, through a retrospective documentary study on articles published during the period from 2011 to 2016. All sections were reviewed against a collective checklist. Articles were grouped by publication year into 2 intervals: early (from 2011 to 2013) and recent (from 2014 to 2016) to identify changes in study characteristics over time.ResultsThe study included 139 original articles. Half of the titles represented aim and 9.4% represented study design. Abstracts were concise, clear, with structured writing format in 98.6%, 93.5%, and 35.3%, respectively. Most introductions included the study aim, while 41% had a rationale. Study timing was reported in 59.0%, while the study design was reported in 25.9%. Inclusion and exclusion criteria were clearly reported in 43.1% and 40.1%, respectively. Statistical methods were mentioned in 80.6%, complete in 30.4%, and appropriate in 85.7%. Four studies reported sample size estimation. Only 52.5% and 58.3% of results were exhaustive and answer the research question, respectively. Incorrect statistical calculations occurred in 41.0%, inappropriate statistical tests or descriptive parameter selection in 26.6%, while inappropriate test application occurred in 49.1%. About 60% of discussions did not completely cover results, 31.7% fully justified the findings, 56.1% followed a logical flow, and 36.7% had contradiction within the text. Conclusions were mostly linked to aim, imprecise, and extrapolating beyond results. On comparing both periods, only a significant less misuse of statistical terms, more reporting conflict of interest, more missing references for cited texts in the recent period, and more participation of NCI over other institutes in the early period were found.ConclusionArticles published in JENCI (from 2011 to 2016) had many methodological and reporting defects and some points of strength. Using the collective checklist developed by this study, continuous training of researchers, involving epidemiologists throughout the whole research process, and applying strict journal reporting and publication rules should be encouraged.
Impact of homicide by a psychiatric patient on forensic psychiatrists: national survey
Authors: Mezey Gillian , Rowe Renarta , Adshead Gwen 
Published: October 2020

Aims and methodTo explore the experiences and support needs of consultant forensic psychiatrists, whose patients had committed homicide while under their care. We circulated a survey to all forensic psychiatrists in the UK, through the Royal College of Psychiatrists, asking about their experiences of a homicide by a patient under their care. Respondents were invited to discuss their experiences further in a structured telephone interview and themes were identified from these discussions. Data were analysed quantitatively and qualitatively.ResultsOne-third of the 86 respondents had had at least one patient who had committed a homicide while under their care. Of these, over three-quarters (78%) reported that the homicide had a significant impact on their personal life, professional life and/or mental/physical health. For some respondents, the impact was severe and long term. Respondents generally felt that they would have been helped by receiving more support in the aftermath of the homicide.Clinical implicationsGreater recognition is needed of the impact on treating psychiatrists of homicide by a patient and more support is needed for affected clinicians. Further research is necessary, including the effects of such events on colleagues in other specialties and examination of the costs versus the benefits of mandatory inquiries after homicides.
Development of CancerLinQ, a Health Information Learning Platform From Multiple Electronic Health Record Systems to Support Improved Quality of Care
Authors: Potter Danielle , Brothers Raven , Kolacevski Andrej , Koskimaki Jacob E. , McNutt Amy , Miller Robert S. , Nagda Jatin , Nair Anil , Rubinstein Wendy S. , Stewart Andrew K. , Trieb Iris J. , Komatsoulis George A. 
Published: October 2020

PURPOSE ASCO, through its wholly owned subsidiary, CancerLinQ LLC, developed CancerLinQ, a learning health system for oncology. A learning health system is important for oncology patients because less than 5% of patients with cancer enroll in clinical trials, leaving evidence gaps for patient populations not enrolled in trials. In addition, clinical trial populations often differ from the overall cancer population with respect to age, race, performance status, and other clinical parameters. MATERIALS AND METHODS Working with subscribing practices, CancerLinQ accepts data from electronic health records and transforms the local representation of a patient’s care into a standardized representation on the basis of the Quality Data Model from the National Quality Forum. CancerLinQ provides this information back to the subscribing practice through a series of tools that support quality improvement. CancerLinQ also creates de-identified data sets for secondary research use. RESULTS As of March 2020, CancerLinQ includes data from 63 organizations across the United States that use nine different electronic health records. The database includes 1,426,015 patients with a primary cancer diagnosis, of which 238,680 have had additional information abstracted from unstructured content. CONCLUSION As CancerLinQ continues to onboard subscribing practices, the breadth of potential applications for a learning health care system widen. Future practice-facing tools could include real-world data visualization, recommendations for treatment of patients with actionable genetic variations, and identification of patients who may be eligible for clinical trials. Feeding these insights back into oncology practice ensures that we learn how to treat patients with cancer not just on the basis of the selective experience of the 5% that enroll in clinical trials, but from the real-world experience of the entire spectrum of patients with cancer in the United States.
Telling History in Feathers: Plumes and Power in Nahua Narratives
Authors: Sousa Lisa 
Published: October 2020

AbstractNahua rulers, nobles, and warriors of the late postclassic and early colonial periods used feathers and elaborate feather costumes in a variety of political and sacred rituals. They acquired these prestige items through gift exchange, trade, conquest, and tribute. This article explores a series of meanings that Nahuas attached to birds, plumes, and feather objects when worn on the body, exchanged in rituals, and discussed in historical accounts. It argues that while Nahuas clearly appreciated feathers for their aesthetic value, they also used them to tell histories of Nahua people’s origins, their feats, and their expansion through commerce and conquest. This article finds that the association between plumes, political authority, and personal and state histories made feathers especially potent symbols in narratives and images of the rise of the Mexica and their fall in 1521.
The Lives and Deaths of Caged Birds: Transatlantic Voyages of Wild Creatures from the Americas to Spain, 1740s–1790s
Authors: Few Martha 
Published: October 2020

AbstractThis essay focuses on New World birds caught up in the eighteenth-century transatlantic trade with other living wild creatures, destined for imperial metropoles. Manuscript sources describing this trade, written by political officials, ships’ captains, doctors, naturalists, animal caretakers, and inspectors who cataloged their arrival to Spanish ports, interacted with the animals, tried to keep them alive aboard the ship, and determined their ability to withstand further transport to their final destinations in Madrid and other cities in Spain. In the process, animals caged aboard ship for several weeks or more developed relationships with one another and with their human caretakers. Their lived experiences show the multiple and complicated ways in which individual captured birds and other creatures helped shape those shipboard environments, disrupting systemic human attempts to construct them as colonial animals who functioned solely as scientific or material objects in empire making.
Effects of polyisoprenoids from Avicennia lanata and Avicennia alba leaves on the gene expression of PI3K, Akt1, mTOR, P53, and EGFR in human colorectal adenocarcinoma WiDr cells
Authors: Qurrohman Taufiq , Hasibuan Poppy Anjelisa Zaitun , Nuryawan Arif , Sumaiyah Sumaiyah , Siregar Etti Sartina , Basyuni Mohammad 
Published: October 2020

Background:Mangrove plants produce polyisoprenoid compounds. Polyisoprenoids have been proven to have anticancer properties. This study investigated the inhibitory activity of polyisoprenoids derived from the leaves of mangrove plantsAvicennia albaandAvicennia lanataregarding the expression of PI3K, Akt1, mTOR, P53, and EGFR genes against human colorectal adenocarcinoma WiDr cells.Methods:Anticancer activity was tested through the MTT assay method performed on WiDr cells. The cell cycle and apoptosis were analysed by flow cytometry and double staining. Gene expression of PI3K, Akt1, mTOR, P53, and EGFR was observed using the RT-PCR method.Results:Cytotoxic activity against WiDr cells showed that the IC50 forA. albaandA. lanatawas 258.14 ug/mL and 243.32 ug/mL, respectively. This observation indicated the possibility to develop moderate anticancer agents. The cell cycle showed that inhibition ofA. albaandA. lanataoccurred in the late phase of apoptosis S (10.60 and 10.51%) and G2-M1 (22.05 and 23.84%), which was higher than negative and positive control cells. Furthermore, the polyisoprenoids derived fromA. albaandA. lanataleaves exhibited anticancer activity in WiDr cells through the downregulated gene expression of PI3K, Akt1, mTOR, and EGFR as well as the upregulated gene expression of P53.Conclusion:This study demonstrated that polyisoprenoids obtained fromA. albaandA. lanataleaves are promising chemopreventive agents for colon cancer.