bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of α Centauri b’s protoplanetary disc
Authors: Martin Rebecca G , Lissauer Jack J , Quarles Billy 
Published: June 2020

ABSTRACT
With hydrodynamical simulations we examine the evolution of a protoplanetary disc around α Centauri B including the effect of the eccentric orbit binary companion α Centauri A. The initially circular orbit disc undergoes two types of eccentricity growth. First, the eccentricity oscillates on the orbital period of the binary, Porb, due to the eccentricity of the binary orbit. Secondly, for a sufficiently small disc aspect ratio, the disc undergoes global forced eccentricity oscillations on a time-scale of around $20\, P_{\rm orb}$. These oscillations damp out through viscous dissipation leaving a quasi-steady eccentricity profile for the disc that oscillates only on the binary orbital period. The time-averaged global eccentricity is in the range 0.05–0.1, with no precession in the steady state. The periastrons of the gas particles are aligned to one another. The higher the disc viscosity, the higher the disc eccentricity. With N-body simulations we examine the evolution of a disc of planetesimals that forms with the orbital properties of the quasi-steady protoplanetary disc. We find that the average magnitude of the eccentricity of particles increases and their periastrons become misaligned to each other once they decouple from the gas disc. The low planetesimal collision velocity required for planet formation suggests that for planet formation to have occurred in a disc of planetesimals formed from a protoplanetary disc around α Centauri B, said disc’s viscosity must be have been small and planet formation must have occurred at orbital radii smaller than about $2.5\, \rm au$. Planet formation may be easier with the presence of gas.
BUDHiES IV: Deep 21-cm neutral Hydrogen, optical, and UV imaging data of Abell 963 and Abell 2192 at z ≃ 0.2
Authors: Gogate A R , Verheijen M A W , Deshev B Z , van Gorkom J H , Montero-Castaño M , Hulst J M van der , Jaffé Y L , Poggianti B M 
Published: June 2020

ABSTRACT
In this paper, we present data from the Blind Ultra-Deep H i Environmental Survey (BUDHiES), which is a blind 21-cm H i spectral line imaging survey undertaken with the Westerbork Synthesis Radio Telescope. Two volumes were surveyed, each with a single pointing and covering a redshift range of 0.164 &lt; z &lt; 0.224. Within these two volumes, this survey targeted the clusters Abell 963 and Abell 2192, which are dynamically different and offer unique environments to study the process of galaxy evolution within clusters. With an integration time of 117 × 12 h on Abell 963 and 72 × 12 h on Abell 2192, a total of 166 galaxies were detected and imaged in H i. While the clusters themselves occupy only 4 per cent of the 73 400 Mpc3 surveyed by BUDHiES, most of the volume consists of large-scale structures in which the clusters are embedded, including foreground and background overdensities and voids. We present the data processing and source detection techniques and counterpart identification based on a wide-field optical imaging survey using the Isaac Newton Telescope and deep ultraviolet (UV) Galaxy Evolution Explorer (GALEX) imaging. Finally, we present H i and optical catalogues of the detected sources as well as atlases of their global H i properties, which include integrated column density maps, position–velocity diagrams, global H i profiles, and optical and UV images of the H i sources.
Dynamical masses of brightest cluster galaxies I: stellar velocity anisotropy and mass-to-light ratios
Authors: Loubser S I , Babul A , Hoekstra H , Bahé Y M , O’Sullivan E , Donahue M 
Published: June 2020

ABSTRACT
We investigate the stellar and dynamical mass profiles in the centres of 25 brightest cluster galaxies (BCGs) at redshifts of 0.05 ≤ z ≤ 0.30. Our spectroscopy enables us to robustly measure the Gauss–Hermite higher order velocity moments h3 and h4, which we compare to measurements for massive early-type galaxies, and central group galaxies. We measure positive central values for h4 for all the BCGs. We derive the stellar mass-to-light ratio ($\Upsilon _{\star \rm DYN}$), and velocity anisotropy (β) based on a multi-Gaussian expansion (MGE) and axisymmetric Jeans Anisotropic Methods (cylindrically and spherically aligned). We explicitly include a dark matter halo mass component, which is constrained by weak gravitational lensing measurements for these clusters. We find a strong correlation between anisotropy and velocity dispersion profile slope, with rising velocity dispersion profiles corresponding to tangential anisotropy and decreasing velocity dispersion profiles corresponding to radial anisotropy. The rising velocity dispersion profiles can also indicate a significant contribution from the intracluster light (ICL) to the total light (in projection) in the centre of the galaxy. For a small number of BCGs with rising velocity dispersion profiles, a variable stellar mass-to-light ratio can also account for the profile shape, instead of tangential anisotropy or a significant ICL contribution. We note that, for some BCGs, a variable βz(r) (from radial to tangential anisotropy) can improve the model fit to the observed kinematic profiles. The observed diversity in these properties illustrates that BCGs are not the homogeneous class of objects they are often assumed to be.
Magnesium abundances in cool metal-polluted white dwarfs
Authors: Blouin Simon 
Published: June 2020

ABSTRACT
The accretion of rocky material is responsible for the presence of heavy elements in the atmospheres of a large fraction of white dwarf stars. Those objects represent a unique opportunity to infer the bulk composition of exoplanetesimals. This chemical characterization requires the use of detailed atmosphere models to determine the elemental abundances at the photospheres of white dwarfs. In this work, we use a state-of-the-art model atmosphere code to reanalyse the first large survey of metal-polluted white dwarfs for which abundances are found for multiple elements. We show that the improved constitutive physics of our models lead to systematically higher Mg abundances than previous analyses. We find an average $\log \, {\rm Mg/Ca}$ number abundance ratio of 1.5. This value is significantly above the reference abundance for chondrites, which is expected as current diffusion models predict that for the cool helium-atmosphere white dwarfs of our sample, Mg should remain in the atmosphere longer than Ca. This helps resolve a recently identified Mg depletion problem, where the planetesimals accreted by white dwarfs were reported to be Mg-deficient compared to the expected composition of their planetary systems.
The role of dietary fibre and prebiotics in the paediatric diet
Authors: Boctor Dana 
Published: June 2020

Abstract
Dietary fibres are resistant to digestion and absorption. Prebiotics are fermentable dietary fibres that confer health benefits through their effects on microbiome composition and activity. The range of physiological benefits from consuming dietary fibres is broad. Encouraging children to eat fibre-rich foods promotes a nutrient-dense diet. Introducing a variety of dietary fibre sources to young children helps establish future dietary choices and a more diverse intestinal microbiota. Low-fibre intake is associated with a higher prevalence of constipation and obesity.
LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a
Authors: Fu Xiaohong , Song Guojing , Ni Rongrong , Liu Han , Xu Zhizhen , Zhang Dinglin , He Fengtian , Huang Gang 
Published: June 2020

Abstract

Objectives
Long non-coding RNA H19 (lncRNA-H19) is highly expressed in fibroblast-like synoviocytes (FLS) from patients with RA. The present study aimed to clarify the pathological significance and regulatory mechanisms of lncRNA-H19 in FLS.

Methods
Mice with CIA were locally injected with LV-shH19. The progression of CIA was explored by measuring arthritic index (AI), paw thickness (PT) and histologic analysis. The growth and cell cycle of human synoviocyte MH7A were assessed by CCK-8 and flow cytometric analysis. The putative binding sites between lncRNA-H19 and miR-124a were predicted online, and the binding was identified by luciferase assay. RT-qPCR, Western blot and luciferase assay were performed to explore the molecular mechanisms between liver X receptor (LXR), lncRNA-H19, miR-124a and its target genes.

Results
The expression of lncRNA-H19 was closely associated with the proliferation of synoviocytes and knockdown of lncRNA-H19 significantly ameliorated the progression of CIA, reflected by decreased AI, PT and cartilage destruction. Notably, lncRNA-H19 competitively bound to miR-124a, which directly targets CDK2 and MCP-1. It was confirmed that lncRNA-H19 regulates the proliferation of synoviocytes by acting as a sponge of miR-124a to modulate CDK2 and MCP-1 expression. Furthermore, the agonists of LXR inhibited lncRNA-H19-mediated miR-124a-CDK2/MCP-1 signalling pathway in synoviocytes. The ‘lncRNA-H19-miR-124a-CDK2/MCP-1’ axis plays an important role in LXR anti-arthritis.

Conclusion
Regulation of the miR-124a-CDK2/MCP-1 pathway by lncRNA-H19 plays a crucial role in the proliferation of FLS. Targeting this axis has therapeutic potential in the treatment of RA and may represent a novel strategy for RA treatment.
Axial and peripheral spondyloarthritis: does psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry
Authors: López-Medina Clementina , Ortega-Castro Rafaela , Castro-Villegas M Carmen , Font-Ugalde Pilar , Puche-Larrubia M Ángeles , Gómez-García Ignacio , Arias-de la Rosa Iván , Barbarroja Nuria , Schiotis Ruxandra , Collantes-Estévez Eduardo 
Published: June 2020

Abstract

Objective
To evaluate whether the presence of psoriasis influences the clinical expression, disease activity and disease burden in both axial and peripheral phenotypes of spondyloarthritis (SpA).

Methods
Patients from the Spanish REGISPONSER registry classified as having SpA according to the ESSG criteria were included. Patients were classified as psoriatic or non-psoriatic depending on the presence of cutaneous or nail psoriasis; thereafter, they were classified as having either axial [presence of radiographic sacroiliitis OR inflammatory back pain (IBP)] or peripheral phenotype (absence of radiographic sacroiliitis AND absence of IBP AND presence of peripheral involvement). Pair-wise univariate and multivariate analyses among the four groups (psoriatic/non-psoriatic axial phenotypes and psoriatic/non-psoriatic peripheral phenotypes) were performed with adjustment for treatment intake.

Results
A total of 2296 patients were included in the analysis. Among patients with axial phenotype, psoriasis was independently associated (P &lt; 0.05) with HLA-B27+ [odds ratio (OR) 0.27], uveitis (OR 0.46), synovitis (ever) (OR 2.59), dactylitis (OR 2.78) and the use of conventional synthetic DMARDs (csDMARDs) (OR 1.47) in comparison with non-psoriatic patients. Among patients with peripheral phenotype and adjusting for csDMARD intake, psoriasis was independently associated with higher age at disease onset (OR 1.05), HLA-B27+ (OR 0.14) and heel enthesitis (OR 0.22). Higher scores for patient-reported outcomes and greater use of treatment at the time of the study visit were observed in psoriatic patients with either axial or peripheral phenotype.

Conclusion
These findings suggest that, among all patients with SpA, psoriasis is associated with differences in clinical expression of SpA, a greater disease burden and increased use of drugs.
Neural synchrony in mother–child conversation: Exploring the role of conversation patterns
Authors: Nguyen Trinh , Schleihauf Hanna , Kayhan Ezgi , Matthes Daniel , Vrtička Pascal , Hoehl Stefanie 
Published: June 2020

Abstract
Conversations are an essential form of communication in daily family life. Specific patterns of caregiver–child conversations have been linked to children’s socio-cognitive development and child-relationship quality beyond the immediate family environment. Recently, interpersonal neural synchronization has been proposed as a neural mechanism supporting conversation. Here, we present a functional near-infrared spectroscopy (fNIRS) hyperscanning study looking at the temporal dynamics of neural synchrony during mother–child conversation. Preschoolers (20 boys and 20 girls, M age 5;07 years) and their mothers (M age 36.37 years) were tested simultaneously with fNIRS hyperscanning while engaging in a free verbal conversation lasting for 4 min. Neural synchrony (using wavelet transform coherence analysis) was assessed over time. Furthermore, each conversational turn was coded for conversation patterns comprising turn-taking, relevance, contingency and intrusiveness. Results from linear mixed-effects modeling revealed that turn-taking, but not relevance, contingency or intrusiveness predicted neural synchronization during the conversation over time. Results are discussed to point out possible variables affecting parent–child conversation quality and the potential functional role of interpersonal neural synchronization for parent–child conversation.
The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia
Authors: Northoff Georg , Sandsten Karl Erik , Nordgaard Julie , Kjaer Troels Wesenberg , Parnas Josef 
Published: June 2020

Abstract
Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) and psychological (information processing) levels. Temporal integration on the neuronal level can be measured by the brain’s intrinsic neural timescale using the autocorrelation window (ACW) and power-law exponent (PLE). Our goal was to relate intrinsic neural timescales (ACW, PLE), as a proxy of temporal integration on the neuronal level, to temporal integration related to self-disorder on psychological (Enfacement illusion task in electroencephalography) and phenomenological (Examination of Anomalous Self-Experience [EASE]) levels. SCZ participants exhibited prolonged ACW and higher PLE during the self-referential task (Enfacement illusion), but not during the non-self-referential task (auditory oddball). The degree of ACW/PLE change during task relative to rest was significantly reduced in self-referential task in SCZ. A moderation model showed that low and high ACW/PLE exerted differential impact on the relationship of self-disorder (EASE) and negative symptoms (PANSS). In sum, we demonstrate abnormal prolongation in intrinsic neural timescale during self-reference in SCZ including its relation to basic self-disorder and negative symptoms. Our results point to abnormal relation of self and temporal integration at the core of SCZ constituting a “common currency” of neuronal, psychological, and phenomenological levels.
Effect of energy source and level, animal age, and sex on the flavor profile of sheep meat12
Authors: Jaborek Jerad R , Zerby Henry N , Wick Macdonald P , Fluharty Francis L , Moeller Steven J 
Published: June 2020

Abstract
The effects of dietary energy source, energy level, sheep age, and sheep sex on flavor and off-flavor intensity were evaluated. Consumer panelists, with previous lamb-eating experience, assessed lamb flavor and off-flavor intensity on a 100-point, end-anchored scale (0 = very mild to 100 = very intense), with off-flavor being defined as anything different than lamb flavor. Lamb longissimus thoracis (LT) and whole, boneless ground shoulder (GS) formed into patties were evaluated. Trial 1 was a randomized complete block design with a 3 × 2 factorial arrangement of treatments. Sheep age (ewe lambs, yearling ewes, and mature ewes; n = 16/age) and ad libitum access to diets [alfalfa pellets (AP) or whole-shelled corn (WSC100)] were treatments. The LT from mature ewes had a greater (P ≤ 0.02) off-flavor intensity when compared with yearling ewes and ewe lambs. Ground shoulder from sheep raised on AP had a greater lamb flavor (P ≤ 0.04) and off-flavor (P ≤ 0.04) intensity than GS from sheep consuming WSC100. Trial 2 was a randomized complete block design with a 3 × 2 × 2 factorial arrangement of treatments. Three dietary treatments [AP, WSC100, and restricted intake of whole-shelled corn to 85% of ad libitum (WSC85)], lamb sex (ewes and wethers; n = 48/sex), and lamb age [short fed, 177 ± 16.6 d of age and 93 ± 20.5 d on feed (DOF); long fed, 294 ± 7.0 d of age and 219 ± 3.8 DOF]. Flavor intensity of the LT was greater (P ≤ 0.05) from lambs offered AP when compared with lambs offered WSC85, whereas lamb flavor of the LT from lambs fed WSC100 was intermediate and not different from the lamb flavor of the LT of lambs fed AP or WSC85. The LT of long-fed lambs had a greater (P ≤ 0.01) lamb flavor and off-flavor intensity when compared with short-fed lambs. Lambs offered AP resulted in a GS with greater lamb flavor intensity (P ≤ 0.01) when compared with lambs offered WSC85 and WSC100, with no diet influence on GS off-flavor intensity. Long-fed lambs produced GS with a greater lamb flavor (P ≤ 0.01) and off-flavor (P ≤ 0.01) intensity when compared with GS from short-fed lambs. Results from the two trials indicate lamb flavor and off-flavor intensity were greater from sheep offered a high-forage (AP) diet when compared with a high-concentrate (WSC) diet. Lamb flavor intensity increased as age of the sheep at harvest increased, suggesting dietary management and associated age-related effects at harvest will influence consumer perception of lamb flavor.
Increased resolution of African swine fever virus genome patterns based on profile HMMs of protein domains
Authors: Masembe Charles , Phan My V T , Robertson David L , Cotten Matthew 
Published: June 2020

Abstract
African swine fever virus (ASFV), belonging to the Asfarviridae family, was originally described in Africa almost 100 years ago and is now spreading uncontrolled across Europe and Asia and threatening to destroy the domestic pork industry. Neither effective antiviral drugs nor protective vaccines are currently available. Efforts to understand the basis for viral pathogenicity and the development of attenuated potential vaccine strains are complicated by the large and complex nature of the ASFV genome. We report here a novel alignment-free method of documenting viral diversity based on profile hidden Markov model domains on a genome scale. The method can be used to infer genomic relationships independent of genome alignments and also reveal ASFV genome sequence differences that determine the presence and characteristics of functional protein domains in the virus. We show that the method can quickly identify differences and shared patterns between virulent and attenuated ASFV strains and will be a useful tool for developing much-needed vaccines and antiviral agents to help control this virus. The tool is rapid to run and easy to implement, readily available as a simple Docker image.
Remimazolam for anaesthesia or sedation
Authors: Sneyd J. Robert , Rigby-Jones Ann E. 
Published: June 2020

Purpose of review
Anaesthesia and sedation are ubiquitous in contemporary medical practice. Developments in anaesthetic pharmacology are targeted on reducing physiological disturbance whilst maintaining or improving titrateability, recovery profile and patient experience. Remimazolam is a new short-acting benzodiazepine in the final stages of clinical development.

Recent findings
Clinical experience with remimazolam comprises volunteer studies and a limited number of clinical investigations. In addition, laboratory investigations explore the implications of its ‘soft drug’ pharmacology.

Summary
Remimazolam provides effective procedural sedation with superior success rates and recovery profile when compared to midazolam. Comparisons with propofol are required. Preliminary studies suggest potential for using remimazolam as the hypnotic component of general anaesthesia. Definitive studies are awaited. As a benzodiazepine, remimazolam could be evaluated as an anticonvulsant and for intensive care sedation.
Urinary Buprenorphine, Norbuprenorphine and Naloxone Concentrations and Ratios: Review and Potential Clinical Implications
Authors: Warrington Jill S. , Warrington Gregory S. , Francis-Fath Samuel , Brooklyn John 
Published: June 2020

Objectives:
Treatment with medications for opioid use disorder such as buprenorphine improves patient morbidity and mortality as well as treatment adherence, an important component of patient care. Buprenorphine is combined with naloxone to reduce misuse; and, when taken sublingually, naloxone is poorly absorbed. Urine testing for buprenorphine is a common way to monitor adherence. Some patients who want to appear adherent may directly tamper with their urine by adding buprenorphine to their urine to allow for the detection without ingestion. Practitioners may rely upon the concentration of buprenorphine and the metabolite, norbuprenorphine, and utilize the ratio of metabolite to parent compound (norbuprenorphine:buprenorphine – N:B ratio) to discern possible evidence of tampering; however, there remains debate as to what specific ratio may signify this practice. Testing for naloxone may also help determine if urine tampering occurred as only low naloxone concentrations are found in the urine when taken by a sublingual route.

Methods:
To determine a reliable N:B ratio that may be used to identify possible urine tampering by adding parent drug directly to urine, we examined 136,605 urine samples for quantitative concentrations of buprenorphine and norbuprenorphine by LC-MS/MS performed at a commercial laboratory. After identifying abnormal ratios (<0.02), we then compared them with naloxone concentrations and specimen validity testing, other markers that may coincide with specimen tampering of this type.

Results:
Correlating urinary buprenorphine and norbuprenorphine concentrations, we found 2 distinct patient populations, which could be distinguished by N:B ratios ranging from 0.01 to 0.2. In addition, while the distribution of urine naloxone concentrations itself did not demonstrate distinct populations, naloxone was able to further flag potential tampered specimens when combined with N:B ratios. Abnormal specimen validity testing was additionally found more commonly in cases with N:B ratios <0.02.

Conclusions:
This comprehensive study compared N:B ratios with naloxone concentrations and specimen validity testing. This study suggests that a N:B ratio of <0.02 in concert with high naloxone concentrations (>1000 ng/ml) can help to identify potential cases of tampered urine samples.