bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between social media addiction and social media bullying: A cross sectional analytic study in Indonesian Youth
Authors: Alfaray Ricky Indra , Ibrahim Yusuf , Faizun Rafiqy Sa’adiy , Irfana Laily 
Published: February 2020

Abstract
BackgroundSocial media had eased communication among people in the last twenty years. However, the ease of being constantly connected also lead to problems, including social media addiction and social media bullying. Association between these two problems has not been researched extensively in Indonesia. Indonesia is the fourth most populous country in the world and said to be the most social media-addicted nation. Approximately 50% of the population is categorized as Youth Generation (Generation Y and Z) who consider social media as a necessity in their daily lives. We conducted this nation-wide study to examine the correlation between social media addiction and the experience of being bullied in a social media platform in Indonesian youth.MethodsAn observational analytic study with a cross sectional design was conducted with a total of 1403 respondents. The samples were collected via consecutive sampling on Instagram. To determine social media addiction, the standard Social Media Disorder (SMD) Scale was used and the experience of being bullied is evaluated using a self-made questionnaire. Chi-square and Coefficient contingency analysis is used to determine the correlation.ResultsAlmost half of the respondents (n = 671, 47.9%) are classified as addicted to social media. More than half of the respondents claimed to have experienced bullying when interacting with people via social media (n = 923, 66%). Analyzing the two nominal independent variables results in a weak yet significant correlation (r = 0.097, p = 0.032).ConclusionThere is a significant correlation between social media addiction and the experience of being bullied in a social media platform in Indonesian youth. Future research are needed to help government prevents social media addiction that proved has correlation with bullying.
Serine hydroxymethyltransferase localised in the endoplasmic reticulum plays a role in scavenging H2O2 to enhance rice chilling tolerance
Authors: Author) Changxun Fang(Former Corresponding , Zhang Pengli , Li Lanlan , Yang Luke , Mu Dan , Yan Xue , Li Zhong , Author) Wenxiong Lin(New Corresponding 
Published: February 2020

Abstract
Background: Rice is a temperature-sensitive crop that can sustain dramatic damage from low temperatures. Overexpression of the Lsi1 gene (Lsi1-OX) in rice enhances its chilling tolerance. This study revealed that a serine hydroxymethyltransferase (OsSHMT) mainly localised in the endoplasmic reticulum (ER) is involved in increasing tolerance to chilling. Results: A higher transcription level of OsSHMT was detected in Lsi1-OX rice than in the wild type. Histone H1 and nucleic acid binding protein were found to bind to the promoter region of OsSHMT and regulate its expression, and the transcription levels of these proteins were also up-regulated in the Lsi1-OX rice. Moreover, OsSHMT interacts with ATP synthase subunit α, heat shock protein Hsp70, mitochondrial substrate carrier family protein, ascorbate peroxidase 1 and ATP synthase subunit β. Lsi1-encoded protein OsNIP2;1 also interacts with ATP synthase subunit β, and the coordination of these proteins appears to function in reducing reactive oxygen species, as the H2O2 content of transgenic OsSHMT Arabidopsis thaliana was lower than that of the non-transgenic line under chilling treatment. Conclusions: Our results indicate that ER-localised OsSHMT plays a role in scavenging H2O2 to enhance the chilling tolerance of Lsi1-OX rice and that ATP synthase subunit β is an intermediate junction between Lsi1 and OsSHMT.
INTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocellular carcinoma with portal vein tumor thrombus
Authors: Song Xiaodong , He Yong , Liang Huihong , Han Menling , Shao Zili 
Published: February 2020

Abstract
Background Portal vein tumor thrombus (PVTT) is common in hepatocellular carcinoma (HCC). Recent studies indicate that more aggressive treatments, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. External radiation therapy and infusion chemotherapy were found to achieve good outcomes; however, the use of low-energy x-ray radiation system (INTRABEAM), intraoperative radiation therapy, and portal vein infusion chemotherapy for PVTT has not been reported. Case Summary We present a case of HCC with PVTT. The patient underwent hemihepatectomy and thrombectomy along with intraoperative radiotherapy (IORT) using a portable INTRABEAM radiation system. Subsequently, to treat PVTT, portal vein infusion chemotherapy with of FOLFOX (leucovorin [Folinic acid], fluorouracil, and oxaliplatin) regimen was administered. There were no obvious post-operative complications. After 14 months follow-up period, no obvious tumor recurrence had been observed, and PVTT gradually disappeared completely. Conclusions IORT using the INTRABEAM radiation system combined with portal vein infusion chemotherapy is promising for select patients with PVTT.
Regulatory Effect of Liraglutide on Endoplasmic Reticulum Stress in Non-alcoholic Fatty Pancreas Disease
Authors: Chen Yong-peng , Chen Jiang-mu , Hu Wei-tao , Chen Zong-chi , Huang Si-ying , Fang Tai-yong 
Published: February 2020

Abstract
Background The pathophysiology and treatment of non-alcoholic fatty pancreas disease (NAFPD) have not been well established. Thus, the aim is to prove hypotheses that endoplasmic reticulum (ER)stress may take part in the pathogenesis of NAFPD. Methods The mice were randomly grouped into normal-group, model-group and experimental-group. The normal-group was fed with regular-diet, while model-group and experimental-group were fed with high-fat-diet for 16 weeks. After the NAFPD model was established successfully, the experimental-group began to give liraglutide 0.6 mg·kg -1 ·d -1 for 4 weeks. The normal-group and model-group were received saline only, total pancreatectomy was performed and pancreas samples were divided for western-blot and immunohistochemical, to detect the expression of GRP78、PERK、eLF2α、ATF4、CASPASE12 and CHOP. Results Western-blot and immunohistochemistry both revealed that the expression of above proteins of model-group were significantly increased compared with normal-group and were also obviously increased compared with experimental-group. (all P ≤0.05). The weight of body and the pancreas of the model-group was markedly higher than that of normal-group, and was also dramatically higher than that of experimental-group (all P ≤0.01). Conclusion Those results show ER stress may be one of the pathogenesis of NAFPD and liraglutide have the effect on regulating ER stress in NAFPD. Those findings have great significance in figuring out the pathophysiology of NAFPD.
Evaluation of the Efficacy and Safety of Intravenous Remdesivir in Adult Patients with Severe Pneumonia caused by COVID-19 virus Infection: study protocol for a Phase 3 Randomized, Double-blind, Placebo-controlled, Multicentre trial
Authors: Wang Yeming , Zhou Fei , Zhang Dingyu , Zhao Jianping , Du Ronghui , Hu Yi , Cheng Zhenshun , Gao Ling , Jin Yang , Luo Guangwei , Fu Shouzhi , Lu Qiaofa , Du Guanghua , Wang Ke , Lue Yang , Fan Guohui , Zhang Yi , Liu Ying , Ruan Shunan , Liu Wen , Jaki Thomas , Hayden Frederick G. , Horby Peter W , Cao Bin , Wang Chen 
Published: February 2020

Abstract
Background: A novel coronavirus emerged in Wuhan, Hubei Province, China towards the end of 2019 (SARS-CoV-2 or COVID-19 virus). Large scale spread within China and internationally led the World Health Organisation to declare a Public Health Emergency of International Concern on 30th January 2020. The clinical manifestations of COVID-19 virus infection include asymptomatic infection, mild upper respiratory symptoms, severe viral pneumonia with respiratory failure and even death. There are no antivirals of proven clinical efficacy in coronavirus infections. Remdesivir (GS-5734), a nucleoside analogue, has inhibitory effects on animal and human highly pathogenic coronaviruses, including highkly pathogenic MERS-CoV and SARS-CoV, in in-vitro and in-vivo experiments. It is also inhibitory against COVID-19 virus in-vitro. The aim of this study is to assess the efficacy and safety of remdesivir in adult patients with severe pneumonia caused by COVID-19 virus infection.Methods: The protocol is prepared in accordance with the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) guidelines. This is a phase 3, randomized, double-blind, placebo-controlled, multicentre trial. Adults (≥18 years) with laboratory confirmed COVID-19 virus infection, and severe pneumonia signs or symptoms, and radiologically confirmed severe pneumonia are randomly assigned in a 2:1 ratio to intravenous remdesivir or placebo for 10 days. The primary endpoint is time to clinical improvement (censored at Day 28), defined as the time (in days) from randomization of study treatment (remdesivir or placebo) until a decline of two categories on a six-category ordinal scale of clinical status (1 ꞊ discharged; 6 ꞊ death). One interim analysis for efficacy and futility will be conducted once half of the total number of events required had been observed.Discussion: This is the first randomized, placebo-controlled trial in 2019-nCoV. Enrolment began in sites in Wuhan, Hubei Province, China on 6th February 2020.
Correlation of Hepatocellular Carcinoma Stemness Indices and Clinical Characteristics and Prognosis
Authors: Li Juan , Zhang Chunting , Yuan Xin , Yu Zujiang 
Published: February 2020

Abstract
Background Recent studies have shown that cancer stem cell (CSC) is related to the occurrence and development of hepatocellular carcinoma(HCC), but the mechanism has not yet been elucidated. Therefore, it is necessary to explore the relationship between HCC stem cells and the survival time of HCC patients and its mechanism to guide the treatment. Methods We downloaded the RNA-Seq data and clinical information from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC). The mRNA gene expression-based stemness index (mRNAsi) and DNA methylation-based stemness index (mDNAsi) were calculated through one-class logistic regression (OCLR). By applying the univariable Cox regression analysis, we found that mRNAsi and mRNAsi were signiﬁcantly correlated with overall survival (OS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis were used to seek for different genes, and searched for hub genes through protein-protein interaction (PPI) analysis. The spearman’s rank correlation coefficient test was applied to analyze the relationship between these hub genes and the stemness indices. Results The mRNA gene expression-based stemness index (mRNAsi) and DNA methylation-based stemness index (mDNAsi) levels of HCC samples from TCGA and ICGC were significantly negatively related to clinical characteristics and OS. Analysis of differentially expressed genes and PPI revealed that SNAP25, KPT19, GABBR1 and EPCAM were significantly negative correlation with mDNAsi. Conclusion Our new model based on stemness indices-related genes was available for predicting prognosis. The SNAP25, KPT19, GABBR1 and EPCAM were potentially therapeutic targets for HCC patients.
Metropolitan age-specific mortality trends at borough and neighbourhood level: The case of Mexico City
Authors: Baca-Lopez Karol , Fresno Cristobal , Espinal-Enriquez Jesus , Flores-Merino Miriam V. , Camacho-Lopez Miguel A. , Hernandez-Lemus Enrique 
Published: February 2020

Abstract
BackgroundUnderstanding the spatial and temporal patterns of mortality rates in a highly inhomogeneous metropolis, is a matter of public policy interest. In this context, there is no previous study that correlates both spatio-temporal and age-specific mortality rates in Mexico City. Methods Spatio-temporal kriging modelling was used over six age-specific mortality rates (from the years 2000 to 2016 in Mexico City), to gain both spatial (borough and neighbourhood) and temporal (year and trimester) data level description. Resulting data were modelled using time-evolution mixed effect models to unblurred mortality age-specific patterns. Posterior tests were carried out to compare mortality averages between geospatial locations. Results Mortality correlation extends in all study groups for as long as 12 years and as far as 13.27 km. The highest mortality rate takes place in the Cuauhtémoc borough, as it is the commercial, touristic and cultural core downtown Mexico City. On the contrary, Tlalpan borough is the one with the lowest mortality rates in all the study groups. Interestingly, post-productive mortality is the first age-specific cause of death, followed by infant, productive, pre-school and scholar groups. Conclusion The combinations of spatio-temporal Kriging estimation and time-evolution mixed effect models, allowed us to unveil relevant time and location trends that may be useful for public policy planning in Mexico City.
Integrated bioinformatics analysis of cartilage for osteoarthritis
Authors: Wang Bin , Zhong Jun-Long , Lin Nan , Chen Yu-Feng , Lu Hua-Ding 
Published: February 2020

Abstract
Background Osteoarthritis (OA) is a joint disease which threatens the health of older people around the world. However, its pathological mechanism remains unclear. In the current study, we aimed to identify the key genes and underlying pathological mechanisms associated with OA. Methods Firstly, GSE117999 was obtained from the Gene Expression Omnibus (GEO) database. We then obtained the DEGs, hub genes and key genes of the dataset using bioinformatics analysis, after which we analyzed these items using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). Furthermore, the target miRNAs of key genes were predicted by miRDB. The Drug Gene Interaction database (DGIdb) was used to predict target drugs for key genes. Receiver operating characteristic (ROC) analysis was employed to evaluate the effectiveness of key genes. Results: A total of 974 DEGs were identified. Furthermore, we found 19 hub genes and 10 key genes. We then predicted that hsa-mir-3613-3p, hsa-mir-548e-5p and hsa-mir-5692a would be closely related to key genes through web tools, and that two drugs, etoposide and everolimus, were highly specific to some key genes. Finally, we analyzed the receiver operating characteristic (ROC) of key genes in the samples and speculated that ESR1 may be a biomarker of OA. Conclusions This study deepens our understanding of OA and may be beneficial for further explorations of the pathological mechanism of the disease.
Clinical efficacy and radiographic K-Rod stabilization for the treatment of multilevel degenerative lumbar spinal stenosis
Authors: Fu Chaohua , Chen Tianju , Yang Yuhao , Yang Hua , Diao Maohui , Zhang Guowei , Ji Zhisheng , Lin Hongsheng 
Published: February 2020

Abstract
Background: This study compares the use of radiographic K-Rod dynamic stabilization to the rigid system for the treatment of multisegmental degenerative lumbar spinal stenosis (MDLSS). Methods: A total of 40 patients with MDLSS who underwent surgical treatment using the K-Rod (n=25) and rigid systems (n=15) from March 2013 to March 2017 were assessed. The mean follow-up period was 29.1 months. JOA, ODI, VAS and modified Macnab were assessed. Radiographic evaluations included lumbar lordosis angle, ISR value, operative and proximal adjacent ROM. Changes in intervertebral disc signal were classified according to Pfirrmann grade and UCLA system. Results: JOA, ODI and VAS changed significantly after the operation to comparable levels between the groups. However, the lumbar lordosis significantly decreased at final follow-up between both groups. The ROM of the proximal adjacent segment increased at final follow-up, but the number of fixed segment ROMs in the K-Rod group were significantly lower at the final follow-up than observed prior to the operation. In both groups, the ISR of the proximal adjacent segment decreased, most notably in the rigid group. The ISR of the non-fusion fixed segments in the K-Rod group increased post-operation and during final follow-up. The levels of adjacent segment degeneration were higher in the rigid group vs. the K-Rod group according to modified Pfirrmann grading and the UCLA system. Conclusions: Compared with the rigid system for treatment of MDLSS, dynamic K-Rod stabilization achieves improved radiographic outcomes and improves the mobility of the stabilized segments, minimizing the influence on the proximal adjacent segment.
Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment
Authors: Liu Su , Wei Hongxia , Li Yuye , Lian Ruochun , Wang Xiaohui , Chen Lanna , Zeng Yong 
Published: February 2020

Abstract
BackgroundIndoleamine 2,3-dioxygenase (IDO) has been reported to play a key role in placental development during normal pregnancy. However, the question of whether endometrial IDO expression affects in vitro fertilization (IVF) pregnancy outcomes remains unclear. The current study was undertaken to investigate whether there was any association between endometrial IDO expression and IVF treatment outcome.MethodsThis retrospective study was designed to compare pregnancy outcomes among women with different endometrial IDO expression levels under their first IVF treatment. A total of 140 women undergoing their IVF treatment were selected from January 2017 to December 2017. Endometrial samples were collected during mid-luteal phase before IVF cycle. The endometrial IDO expression levels were analyzed by immunohistochemistry, and compared between women who were pregnant or not. A logistic regression analysis was performed to determine the impact of endometrial IDO expression on live birth.ResultsNo significant differences in the endometrial IDO expression levels were found between women who had clinical pregnancy and those who failed (P>0.05). However, the endometrial IDO expression level was significantly higher among women who had live birth compared with those who had no live birth (P=0.031). Additionally, after adjusting for differences in maternal age, BMI and duration of gonadotropin stimulation, women with higher IDO expression level had an increased live birth rate (adjusted odds ratio [aOR] 2.863, 95% confidence interval [CI] 1.180-6.947). ConclusionsHigher endometrial IDO expression level during mid-luteal phase is associated with an increased live birth rate in women undergoing their first IVF treatment.
Discussion on the Efficacy of Vascular Smooth Muscle Technology in the Treatment of Thin Endometrial Infertility
Authors: sun caixia , wang zhongmin 
Published: February 2020

Abstract
Objective: To clarify the efficacy of vascular smooth muscle technology in the treatment of thin endometrial infertility, and to provide a theoretical basis for the further diagnosis and treatment of thin endometrial infertility. Methods: In accordance with the inclusion and exclusion criteria, 2015.01-2020.01 selected thin endometrial infertility patients undergoing freeze-thaw embryo transfer at the Female Pelvic Floor Urinary Reconstructive Center in Dalian Municipal Women and Children’s Medical Center were selected according to different treatment methods. For the two groups, pure estrogen therapy was used as the control group, and vascular smooth muscle technology combined with estrogen therapy was used as the study group. All patients' endometrial thickness and pregnancy and delivery were recorded before and after treatment. Results: 1. The endometrial thickness of the study group was significantly larger than that of the control group after treatment, the difference was statistically significant ( P <0.05); 2. 80 patients in the study group, 13 cases of successful pregnancy and delivery, 5 cases of biochemical pregnancy; the endometrial changes of the 50 patients in the control group was not obvious after treatment, none of the endometrial thicknesses reached the embryo transfer standard, and none were transplanted. Conclusion: Vascular smooth muscle technology can effectively increase the thickness of endometrium, with the aim of assisting to improve the pregnancy success rate of thin endometrial infertility through vascular smooth muscle technology.
Impact of ovarian metastatectomy on survival outcome of colorectal cancer patients with ovarian metastasis: a retrospective study
Authors: Li Xiaofen , Huang Hai , Ran Longyao , Fang Chao , Yu Yongyang , Luo Manxi , Qiu Meng 
Published: February 2020

Abstract
Background

Ovarian metastasis from colorectal cancer (CRC) is rare and lacks standard treatment. The benefit of metastatectomy remains to be elucidated. This study was conducted to assess the impact of metastatectomy on survival outcome and explore prognostic factors in ovarian metastatic CRC patients.

Results

Information of ovarian metastatic CRC patients between January 2008 and December 2017 were collected retrospectively from database of West China Hospital, Sichuan University. Totally, 68 female patients from a cohort of 2170 metastatic CRC cases were eligible. The median age at diagnosis was 46.5 years old. The median DSS was 25.0 months (95% confidence interval (CI): 21.0-29.0 months). Kaplan-Meier analysis and log-rank test showed that complete resection of ovarian metastases (median DSS: 33.0 months) could significantly prolong patients’ survival time, comparing with palliative and no resection (median DSS: 20.0 months and 22.0 months, respectively), regardless of systemic chemotherapy (P<0.05). Multivariate analysis demonstrated regional lymph nodes metastasis of primary tumor (hazard ratio (HR): 3.438, 95%CI: 1.094-10.810, P=0.035), primary tumor resection (HR: 6.436, 95%CI: 1.770-23.399, P=0.005), differentiation grade (HR: 0.272, 95%CI: 0.107-0.693, P=0.006), complete resection of ovarian metastases (versus palliative resection: HR: 17.091, 95%CI: 3.040-96.099, P=0.001; versus no resection: HR: 9.519, 95%CI: 1.581-57.320, P=0.014), and systemic chemotherapy (HR: 3.059, 95%CI: 1.089-8.595 P=0.034) were independent prognostic factors.

Conclusions

Complete resection of ovarian metastases could independently predict favorable survival in ovarian metastatic CRC, while palliative resection could not improve patients’ prognosis compared with no resection.
Primary renal NUT carcinoma identified by next-generation sequencing: A case report and literature review
Authors: Yang Fei , Shen Danhua , Shi Junping 
Published: February 2020

Abstract
Background NUT carcinoma is a rare aggressive squamous cell carcinoma subtype genetically defined by NUTM1 rearrangements. NUT carcinoma usually has a primitive differentiation state and can be easily misdiagnosed as an undifferentiated carcinoma or Ewing sarcoma. Case presentation We report a case of NUT carcinoma of renal origin initially diagnosed as a malignant small round-cell tumor, likely to be Ewing sarcoma/primitive neuroectodermal tumor. Based on next-generation sequencing (NGS), the diagnosis was revised to NUT carcinoma with a characteristic NUTM1 rearrangement. The patient relapsed after surgery and received a standard NUT carcinoma treatment. However, due to advanced neoplasm progression, first-line chemotherapy failed and the patient died. Conclusion Routine NUT immunohistochemistry staining, NGS, and/or fluorescent in situ hybridization for poorly differentiated carcinoma and sarcoma tumors can help avoid misdiagnosis of NUT carcinoma-related tumors, allowing patients to benefit from bromodomain and extra-terminal motif inhibitor therapy.