bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification of the epicuticular waxes of plant leaves due to increased sunlight intensity
Authors: Lykholat Y. V. , Khromykh N. A. , Didur O. O. , Alexeyeva A. A. , Lykholat T. Y. 
Published: April 2020

Climatic changes observed around the world in recent years are associated with an increase in the solar radiation intensity and temperature and reduction in the humidity. Fluctuations of environmental factors significantly change the conditions for the existence of plants, which dictates the need for adaptive reactions of plant organisms at the different levels of their organization. Such dangerous processes as excessive heating of the surface of plant leaves and water loss can be prevented by the formation of a cuticle, which is a complex composition consisting of cutin and the soluble intracuticular and epicuticular waxes. We suggested that the structure, component composition and properties of the cuticle of trees undergo adaptive changes due to microclimatic conditions in different parts of the tree crown. The study was aimed at the identification and evaluation of light-induced differences in the accumulation and composition of leaf epicuticular waxes of Ulmus trees (native U. minor Mill. and alien U. pumila L.), and was conducted in 2018–2019 in Dnipro city located in the steppe zone of Ukraine. Analysis of the waxes’ chloroform extracts was carried out using GC Shimadzu 2010 PLUS equipped with a flame ionization detector and capillary column SP-2560. The highest amount of epicuticular waxes (12.23 ± 0.39 µg/cm2) was on the sunlit leaves of U. pumila, and wax deposits on the sunned leaves exceeded twice those on the shaded leaves in both U. minor and U. pumila. Long-chain hydrocarbons detected in the epicuticular waxes of both elm species were represented by free fatty acids, aldehydes, alcohols, and n-alkanes in various ratios. In the epicuticular waxes of U. minor, fatty acids dominated both on shaded and sunned leaves, while alkanes together with alcohols were the main components in U. pumila waxes, especially on the sunlit leaves. According to our results, local high illumination of leaves in the crown of both elm species caused increase in share of long-chain alkanes (1.2–1.9 times), but simultaneous reduction of the content of free fatty acids (1.5–16.8 times) in the epicuticular waxes’ composition. General patterns of the leaf epicuticular waxes’ modification due to increased solar radiation and air temperature can indicate the adaptive metabolic responses of woody plants to changing climatic conditions.
Adaptive strategy of Rapana venosa (Gastropoda, Muricidae) in the invasive population of the Black Sea
Authors: Slynko Е. Е. , Slynko Y. V. , Rabushko V. I. 
Published: April 2020

We conducted molecular-genetic and morphological studies on the veined rapa whelk Rapana venosa (Valenciennes, 1846) in the Crimean waters of the Black Sea in order to determine possible reasons of the invasive success of this mollusk. Molecular-genetic tests were performed using COI gene; the surveyed samples reliably identified to R. venosa species. We compared the data on initial (from the Far-Eastern seas) and some invasive populations. In the natural conditions of the Yellow, East China Seas, and the Sea of Japan, the genetic diversity of rapa whelk is high (Hd = 0.933, π = 0.002). In all the invasive populations of rapa whelk (Black Sea, European and North American), an extremely low level of haplotypic and nucleotide diversity was determined (Hd = 0.0, π = 0.0). Despite low values of genetic diversity, the invasive populations of rapa whelk are characterized by ecological success. We noted stable growth of populations, tolerance to diseases and parasites, effective reproduction, high fertility. This contradicts the main provisions of the population genetics theory of formation of edge of range populations, because usually only a small number of specimens of rapa whelk were introduced. The explanations of the unique condition of the invasive populations of rapa whelk, both from an ecological perspective (high resistance to fluctuations of hydrological factors and chemical pollution, absence of enemies, high fertility) and genetic perspective (high selective value of separate haplotypes settled in the new water areas) have not been confirmed. We determined that a very important factor for the naturalization of the rapa whelk at low genetic diversity is the intra-species morpho-ecological divergence. In the Crimean water area of the Black Sea, R. venosa was found to have two morpho-ecological forms associated with the peculiarities of the development of the proportions of the shell. Study of successful invasive species would allow timely and adequate reaction to new cases of introduction.
Modelo de regresión multinominal logística de gestión del pensamiento innovador (TPIG), aplicado a los gerentes del sector de la construcción: Caso de Sincelejo
Authors: Manjarres Márquez José Alexander , Niebles Nuñez William , Romero Alvarez Yaneth Patricia 
Published: April 2020

Objetivo: Validar una prueba de pensamiento innovador entre los gerentes de las empresas del sector de la construcción en el municipio de Sincelejo para saber en qué medida son creativos e innovadores. Metodología: Corresponde a un estudio de naturaleza correlacional, que explora la confiabilidad del contenido y la validez de la Prueba de pensamiento innovador de gestión (MITT), capturando y cuantificando las capacidades de los emprendedores. Resultados: La evidencia es válida en la aplicabilidad de la Prueba de pensamiento innovador de gestión (MIIT) y la concordancia entre las variables observadas y predichas. Conclusiones: La Prueba de pensamiento innovador de gestión (MIIT) permite medir la capacidad de innovación como medida de realización de la creatividad entre los gerentes del sector de la construcción de una manera válida y confiable.
Estudio de factores que afectan la integración de los sistemas de gestión en el Centro Nacional de Biopreparados, Cuba
Authors: Maluf Blanco Arianna , Michelena Fernández Ester Susana 
Published: April 2020

Objetivo: Diagnosticar de manera integrada la gestión de la calidad, ambiental y de seguridad y salud en el Centro Nacional de Biopreparados para la integración de los sistemas de gestión. Metodología: A partir de la revisión bibliográfica relacionada con las tendencias actuales para la integración de modelos de gestión, el empleo de métodos como la encuesta, la observación, trabajo en equipo, listas de chequeo, matriz DAFO y estadística descriptiva, se diseñó y aplicó un procedimiento que permitió detectar las brechas que incidían en la organización tanto en el contexto interno como externo. Resultados: Como resultado se obtuvo que existía duplicidad en la información documentada, no integración de políticas y objetivos de gestión, identificación y evaluación de los riesgos de cada sistema de forma independiente, auditorías no integradas, consumo de agua y electricidad como aspectos ambientales con impacto negativo, el grado de integración de los requisitos de las normas medianamente cumplido y poca integración de los requisitos de las normas percibida por los trabajadores. Conclusiones: La aplicación del procedimiento permitió detectar las brechas que influían de manera negativa en la gestión y el desempeño de la organización, lo que condujo a identificar la necesidad de diseñar e implementar un modelo integrado de gestión de la calidad, ambiental y de seguridad y salud en el trabajo.
La Teoría de restricciones para los procesos de gestión y control en las IPS del Caribe Colombiano
Authors: Hernandez Palma Hugo Gaspar , Solórzano Movilla José , Jinete Torres José 
Published: April 2020

Objetivo: Este trabajo buscó identificar las restricciones físicas y políticas que existen en las IPS del Distrito Especial, Industrial y Portuario de Barranquilla, Atlántico, Colombia. Metodología: Se diseñó un instrumento de recolección de información a partir de preguntas tipo escala, direccionado a una muestra de 149 IPS de Barranquilla. Resultados: Se evidencia que las restricciones físicas más preponderantes en las IPS tienen que ver con la infraestructura, la materia prima y el capital humano; mientras que las restricciones políticas, se centran en relaciones de autoridad vertical, dificultades en la medición de la efectividad y eficiencia de los procesos y problemas respecto a la colaboratividad y relaciones interpersonales laborales. Conclusiones: Los problemas de productividad y competitividad de las IPS no radican exclusivamente en el pago tardío de las EPS o ARL; al respecto, también son importantes las dificultades en la gestión ocasionadas por limitantes o restricciones físicas y políticas.
Tissue synthesis of some components of the renin-angiotensin system in hypertensive patients with localized kidney cancer
Authors: Osokin R. A. , Aboyan I. A. , Komarova E. F. , Maksimov A. Yu. , Komarova E. Yu. 
Published: April 2020

Background. In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer (KC) has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of KC.Objective: to study the state of RAS in tumor and peritumoral tissues in patients with KC on the background of arterial hypertension. Materials and methods. In patients with localized KC T1N0M0 and grade I–II arterial hypertension without special treatment (n = 40) in the samples of tumor, peritumoral and histologically unchanged tissue, the levels of angiotensins 1, 2, 1–7 (AT1, AT2, AT(1–7)) of angiotensin-converting enzymes (ACE, ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55).Results. In patients with KC, the level of AT1 is 1.5 times higher (p <0.05), and AT2 is 1.6 times higher (p <0.05) in tumor tissue against the background of unchanged content in peritumoral tissue compared with histologically unchanged tissue. The level of ACE is higher than histologically unchanged tissue by 2.7 times, ACE2 – by 1.6 times (in all cases p <0.05), and in peritumoral tissue it is identical in histologically unchanged tissue.In patients with KC and arterial hypertension, the level of AT1 and AT2 in the tumor tissue is 1.8 times higher (p <0.05) and 2.1 times (p <0.01), respectively, the content of AT(1–7) is 1.6 times (p <0.01). In peritumoral tissue, AT1 is 1.6 times higher (p <0.01) and AT2 is 1.9 times higher (p <0.05). The level of AT(1–7) in the peritumoral tissue is identical to the values in the histologically unchanged tissue. The content of ACE and ACE2 in tumor tissue is 3.6 and 2.9 times higher, respectively, and in peritumoral tissue is identical to that in tumor tissue. Correlation analysis revealed a reliable direct relationship in the studied groups for all parameters, while in the peritumoral tissue of hypertensive patients, the relationship between the average blood pressure and the RAS peptide and enzymes content had a higher tightness.Conclusion. An increase in the levels of AT1 and AT2, ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized KC, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension.
Influence of surgical approach on enhanced recovery after surgery in laparoscopic radical nephrectomy
Authors: Perlin D. V. , Dymkov I. N. , Davydova E. A. , Shmanev A. O. , Perlina A. V. 
Published: April 2020

Background. Аdvantages of the retroperitoneal approach, successfully applied in some clinics, but only a few studies on direct comparison of laparoscopic and retroperitoneoscopic radical nephrectomy.The study objective: to compare transperitoneal and retroperitoneal access during laparoscopic radical nephrectomy.Materials and methods. The study included 332 patients who underwent laparoscopic radical nephrectomy for renal cell carcinoma T1a–T3b. Transperitoneal access – 134, retroperitoneal – 198.Results. The mean time of laparoscopic radical nephrectomy, as well as the time before clipping of the renal artery were significantly less in retroperitoneal access (161 ± 59 and 30 ± 24 min, respectively, compared with 178 ± 65 and 38 ± 39 min – with transperitoneal). The number of removed lymph nodes, and the number of patients detected with “positive” lymph nodes, and death from progression of disease was not significantly different between the groups transperitoneal and retroperitoneal access with an average follow-up period, 42.5 and 47.8 months respectively.Conclusion. Despite the lower popularity retroperitoneal access, the method has advantages in enhanced recovery after surgery (ERAS), particular frequency of general perioperative complications, duration of epidural anesthesia, time of normalization of bowel function and length of hospital stay compared with transperitoneal access. The method is preferred for the old age and patients with comorbidity, especially of the cardiovascular system and respiratory organs.
Choice of urine derivation method after radical cystectomy in the high anesthesiological risk group
Authors: Shkodkin S. V. , Idashkin Yu. B. 
Published: April 2020

Background. Radical cystectomy is the standard treatment for muscle-invasive bladder cancer. Muscle invasion can occur in 48 % of patients. Epidemiologically, the peak incidence of bladder cancer is observed in men at the seventh decade of life. At the time of diagnosis, many of these patients have serious comorbidity. The trauma of radical cystectomy in combination with comorbidity creates an insurmountable barrier to radical treatment in a large part of patients. Refusal to use intestinal segments for urine diversion dramatically reduces the invasiveness of the intervention. However, the implementation of bilateral ureterocutaneostomy is associated with a greater frequency of pyelonephritis due to the use of external stents and scarring of the ureterocutaneostomy. A transureteroureterostomy with a unilateral ureterocutaneostomy can be a definite alternative.Objective: to evaluate the effectiveness of cross ureteroureterostomy for urine derivation after radical cystectomy in patients with muscle-invasive bladder cancer and a high risk of perioperative complications.Materials and methods. The article analyzes 28 cystectomies for muscle-invasive bladder cancer in patients with severe concomitant pathology who underwent transureteroureterostomy with unilateral ureterocutaneostomy for urine derivation. Results. It was shown that this intervention does not have high morbidity, does not increase the incidence of early postoperative complications, and relieves patients from bilateral urostoma. Among late complications, inflammatory ones predominate due to obstruction of the external stent. The authors highlight the tactics and technical aspects of managing such patients with obstructive pyelonephritis and the experience of drainage-free management.Conclusion. Transureteroureterostomy with unilateral ureterocutaneostomy after cystectomy for muscle-invasive bladder cancer can be considered as the operation of choice in patients with a burdened comorbidity.
Identification of factors influencing delayed presentation of cancer patients
Authors: Sharma Gargie , Gupta Sweety , Gupta Amit , Kalyani Vasantha C. , Rohilla Kusum K. , Thozhuthungal Sreejeev Aathira , Yanthan Yan Pothung , Kumar Utkarsh , Das Biswajyoti , Sharma Gaurav , Sehrawat Amit , Gupta Manoj 
Published: April 2020

Background: Delayed presentation of patients of cancer is associated with poorer survival. Early presentation, timely diagnosis and treatment are critical factors in improving long-term survival for patients with cancer. Thus, reducing delays in diagnosis of cancer should be a priority. Against this backdrop this study was conducted to identify factors leading to delayed presentation of patients in advanced stages of cancer at our institute. Methods: Newly diagnosed patients of cancer coming to radiation oncology, surgery and medical oncology outpatient departments were included in this study. Data was collected in a pre-validated questionnaire format.Results: 360 patients were included. Majority of patients 212 (58.9%) were male. 66.7% patients were from rural areas. Most of the patient’s educational level was upto primary schooling 178 (49.4%) and caregiver educational level was upto primary schooling 153 (42.5%). Reason for alternative treatment correlated significantly with patient awareness about the disease (p<0.03). Most common reason of the time gap given by patients was symptom appraisal 258 (71.7%).Conclusions: Educational level of patients, symptom appraisal, fear of side effects of treatment and awareness about disease were main reasons for delay in presentation of cancer patients. So, education regarding warning signs of cancer and symptom appraisal are important in reducing delays in presentation.
Profile of parotid tumors visiting tertiary health care facility in North India
Authors: Munjal Manish , Tuli Nitika , Rishi Porshia , Singh Harjinder , Talwar Shivam , Sharma Salony , Munjal Shubham 
Published: April 2020

<p class="abstract"><strong>Background:</strong> Neoplastic lesions of head and neck presenting in a tertiary care facility were analyzed. This study is proposed to examine the epidemiological pattern of parotid tumors, histopathology correlations and relation of facial nerve with the parotid tumors.</p><p class="abstract"><strong>Methods:</strong> This is a retrospective study of patients with head and neck neoplasms who presented to the ENT tumour clinic of Dayanand Medical College and Hospital over a period of 2 years i.e., from January 2018 to December 2019. Patients’ demographic profile, histopathological reports and pre-operative fine needle aspiration cytology reports were studied. </p><p class="abstract"><strong>Results:</strong> Total number of cases of head and neck neoplasms were 273 over a period of 2 years. Parotid tumours constituted 9.1% of the total head and neck neoplasm. Predominant age group in case of benign parotid tumors was 40-50 years, whereas in case of malignant neoplasms was 50-60 years. Posterior belly of digastric along with tragal pointer are the most consistent and reliable landmarks for Identification of facial nerve.</p><p><strong>Conclusions:</strong> Identification of trunk of facial nerve using anatomical landmarks is the keystone for parotid surgery. Posterior belly of digastric along with tragal pointer are the most consistent and reliable landmarks for Identification of facial nerve. </p>
Role of pure tone audiometry in assessing ossicular status in patients with mucosal type of chronic otitis media
Authors: Das Deepthy , Sriraman Gurumani , Rajasekaran Valli 
Published: April 2020

<p class="abstract"><strong>Background:</strong> Chronic suppurative otitis media (CSOM) is the disease of the middle ear cleft, which presents as hearing loss and ear discharge. This study aimed to assess the role of pure tone audiometry (PTA) in analysing the ossicular erosion in mucosal type of CSOM subjects.</p><p class="abstract"><strong>Methods:</strong> The current cross-sectional study was conducted among 60 people with mucosal CSOM. Preoperative hearing was assessed by PTA. The surgeries were done and intra operative ossicular status were recorded. IBM SPSS 20 software was used for the analysis. Student t-test was used to correlate ossicular status and PTA findings. </p><p class="abstract"><strong>Results:</strong> Among 60 subjects, 12 (20%) patients had eroded incus and 53 (88.3%) had normal stapes. The malleus was preserved in all patients. The result of our study showed that an average ABG of 58 dB at 500 Hz, 47 dB at 1 kHz, 41 dB at 2 kHz and 41 dB at 4 kHz in patients with ossicular erosion. ABG for 500 Hz and 1 kHz were statistically significant for eroded incus. ABG for 500 Hz, 1 kHz, 2 kHz and 4 kHz were all statistically significant for eroded stapes.</p><p class="abstract"><strong>Conclusions:</strong> There is a significant difference between the PTA findings at different frequencies between intact and eroded ossicular chain. Pre-operative ABG helps us to assess the status of incus and stapes.</p>
A comparative study of post-operative outcomes in type 1 tympanoplasty using tragal chondroperichondrial shield graft and temporalis fascia graft
Authors: Muniasamy Pradeep Kumar , Srinivasan Dharanya Gopalakrishnan , Velayutham Prabu , Savery Nishanth , Krishnaswami Balasubramanian , Vellikannu Ramkumar 
Published: April 2020

<p class="abstract"><strong>Background:</strong> Type 1 tympanoplasty is the reconstruction of perforated tympanic membrane with an intact and mobile ossicular chain. Among various autologous graft materials, temporalis fascia and tragal chondroperichondrium are commonly used, having their own merits and demerits. In our study, we have compared the results and postoperative outcomes of tympanoplasty using temporalis fascia and tragal chondroperichondrium.</p><p class="abstract"><strong>Methods:</strong> This prospective comparative study included 60 cases of chronic suppurative otitis media - tubotympanic disease (CSOM-TTD) in a tertiary care centre. They were randomised into two groups of 30 patients each and were subjected to tympanoplasty using either tragal cartilage-perichondrium (group 1) or temporalis fascia graft (group 2) from November 2017 to May 2019. Objective hearing improvement at 1st, 3rd and 6th month postoperative follow-up and graft uptake rate at 3rd month were compared. </p><p class="abstract"><strong>Results:</strong> Incidence of cases was more in the age group between 31-45 years age group (53.3%). Graft uptake rate was 96.6% for temporalis fascia group and 83.33% for tragal group (p value - 0.194). Preoperative air-bone (AB) gap in group 1 was found to be 25±4.09 dB which improved to 11.73±2.21 dB at 6 months and in group 2, it was 25.7±3.94 dB which improved to 14.06±3.68 dB at 6 months. Mean improvement in hearing for tragal group (13.27 dB) was better than temporalis fascia group (11.64 dB) (p value &lt;0.001).</p><p class="abstract"><strong>Conclusions:</strong> Both temporalis fascia and tragal chondroperichondrium are suitable graft materials for tympanoplasty, although graft uptake was clinically better with the use of temporalis fascia.</p><p> </p>