bluuebunny/crossref_metadata_2025_split huggingface dataset:
A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifiescis-andtrans-regulatory elements ofOct4in murine ESCs
Authors: Canver Matthew C. , Tripathi Pratibha , Bullen Michael J. , Olshansky Moshe , Kumar Yogesh , Wong Lee H. , Turner Stephen J. , Lessard Samuel , Pinello Luca , Orkin Stuart H. , Das Partha Pratim 
Published: November 2019

AbstractRegulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the non-coding genome and control gene expression programs either in–cisor in– trans. Putative REs have been identified largely based on their regulatory features (co-occupancy of ESC-specific transcription factors, enhancer histone marks and DNase hypersensitivity) in mouse embryonic stem cells (mESCs). However, less has been established regarding their regulatory functions in their native context. We deployedcis-andtrans-regulatory elements scanning through saturating mutagenesis and sequencing (ctSCAN-SMS) to target elements within the ∼12kbcis-region (Cis-REs; CREs) of theOct4gene locus, as well as genome-wide 2,613 high-confidencetrans-REs (TREs), in mESCs. ctSCAN-SMS identified 10 CREs and 12 TREs, as novel candidate REs of theOct4gene in mESCs. Furthermore, deletions of these candidate REs confirmed that the majority of the REs are functionally active, and CREs are more active than TREs in controllingOct4gene expression. A subset of active CREs and TREs physically interact with theOct4promoter to varying degrees; specifically, a greater number of active CREs compared to active TREs, physically interact with theOct4promoter. Moreover, comparative genomics analysis reveals that more number of active CREs than active TREs are evolutionary conserved between mouse and primates, including human. Taken together, our study demonstrates the reliability and robustness of ctSCAN-SMS screening to identify critical REs, and investigate their roles in the regulation of transcriptional output of a target gene (in this caseOct4)in their native context.
An integrated production-distribution planning with a routing problem and transportation cost discount in a supply chain
Authors: Karimi Behzad , Ghare Hassanlu Mahsa , Niknamfar Amir Hossein 
Published: November 2019

Purpose
The motivation behind this research refers to the significant role of integration of production-distribution plans in effective performance of supply chain networks under fierce competition of today’s global marketplace. In this regard, this paper aims to deal with an integrated production-distribution planning problem in deterministic, multi-product and multi-echelon supply chain network. The bi-objective mixed-integer linear programming model is constructed to minimize not only the total transportation costs but also the total delivery time of supply chain, subject to satisfying retailer demands and capacity constraints where quantity discount on transportation costs, fixed cost associated with transportation vehicles usage and routing decisions have been included in the model.

Design/methodology/approach
As the proposed mathematical model is NP-hard and that finding an optimum solution in polynomial time is not reasonable, two multi-objective meta-heuristic algorithms, namely, non-dominated sorting genetic algorithm II (NSGAII) and multi-objective imperialist competitive algorithm (MOICA) are designed to obtain near optimal solutions for real-sized problems in reasonable computational times. The Taguchi method is then used to adjust the parameters of the developed algorithms. Finally, the applicability of the proposed model and the performance of the solution methodologies in comparison with each other are demonstrated for a set of randomly generated problem instances.

Findings
The practicality and applicability of the proposed model and the efficiency and efficacy of the developed solution methodologies were illustrated through a set of randomly generated real-sized problem instances. Result. In terms of two measures, the objective function value and the computational time were required to get solutions.

Originality/value
The main contribution of the present work was addressing an integrated production-distribution planning problem in a broader view, by proposing a closer to reality mathematical formulation which considers some real-world constraints simultaneously and accompanied by efficient multi-objective meta-heuristic algorithms to provide effective solutions for practical problem sizes.
Exploring self-care abilities among women in prisons of West Bengal, India
Authors: Chatterjee Debolina , Chopra Chatterjee Suhita , Bhattacharyya Tulika 
Published: November 2019

Purpose
Self-care is defined as the ability to take care of one’s body and health with or without the help of healthcare personnel. The purpose of this paper is to explore the opportunities for self-care among imprisoned women within the constraints of a confined life, which, in turn, affect their health.

Design/methodology/approach
Primary data have been collected through semi-structured interviews with 90 women in three prisons in the Indian state of West Bengal.

Findings
Findings reveal that a majority of the women cited the inability to self-care was due to factors such as constricted architecture, specific penal policies that thwarted relational contexts in prisons and also the loss of control over their consumptive choices. However, it was found that coping mechanisms also existed among some women who actively constituted penal spaces for self-care. Many long-term imprisoned women tried to actively engage themselves in daily activities such as the “labour” allotted to them.

Practical implications
The paper concludes that abilities to self-care have a deep impact on the health of women, which if not facilitated will lead to a health depleting experience. At a time when Indian prisons are focussing on rehabilitation, the recommendations for providing opportunities for self-care in prisons can minimize the “pains” of imprisonment and pave the way for rehabilitation.

Originality/value
The research is based on data collected during original fieldwork conducted in three prisons in West Bengal, India. It provides valuable insights on how penal environments affect self-care opportunities of imprisoned women.
Race and place
Authors: Murji Karim , Picker Giovanni 
Published: November 2019

Purpose
The purpose of this paper is to introduce the special issue on race and place.

Design/methodology/approach
The approach used by the authors is to combine an overview of sociological debates on place within a framework that makes the case for a relational approach to race, space and place.

Findings
The overview provides an account of place in sociology, of the relationality of race and place, and the making of race and place in sociological work.

Originality/value
The Introduction sets the papers in context, providing a short account of each of them; it also aims to present an argument for attention to race and place in sociology in a setting characterized by racism and reaction.
The alignment of global equity and corporate bonds markets with the Paris Agreement
Authors: Thomä Jakob , Hayne Michael , Hagedorn Nikolaus , Murray Clare , Grattage Rebecca 
Published: November 2019

Purpose
To comply with the adopted Paris Agreement, global finance flows must be measured against climate scenarios consistent with possible pathways towards limiting global warming to 2°C or less. For this, there must be proven and accepted accounting principles for assessing financial plans of climate relevant actors against climate models. As there are a variety of data sources describing the financial plans of relevant actors, these principles must accommodate a variety of reported information, while still yielding relevant metrics to different stakeholders. The paper aims to discuss these issues.

Design/methodology/approach
A set of accounting principles tested by governments, financial supervisory bodies and both institutional investors and mangers, covering global-listed equity and corporate bond investment is described.

Findings
The application illustrates that a common set of accounting principles can act across both asset classes and provide relevant metrics to multiple stakeholders.

Research limitations/implications
The principles require data of varying quality and are ultimately unverified. Thus, the definitive quality of the output metrics is uncertain and is yet to be characterized. The principles are yet to be applied to the credit market as the information is seldom publicly available, but it too plays an important role in the required market transition and therefore must be incorporated into these guiding principles of analysis.

Practical implications
The principles allow for standardised assessment of financial flows of equity and corporate debt with global climate scenarios.

Originality/value
It illustrates the acceptance of a common set of accounting principles that is relevant across different actors and asset classes and summarizes the principles underlying the first climate finance scenario analyses.
Walking the talk
Authors: Scheetz Andrea M. , Fogarty Timothy J. 
Published: November 2019

PurposeBased on exchange theory and the generalized norm of reciprocity, psychological contracts perceived by employees are believed to have dysfunctional consequences for organizations if breached. This paper aims to study the willingness of employees to report fraud, as such is an important aspect of internal control for organizations.Design/methodology/approachA 2 × 2 between-subjects experiment was conducted in which 99 participants with diverse accounting backgrounds were first asked questions about their preconceived beliefs (psychological contract) regarding how reports of unethical conduct would be managed, and their reaction if these beliefs were broken (psychological contract violation). Participants were given a hypothetical situation of fraud and then asked to indicate their likelihood of reporting fraud to a supervisor.FindingsThe main hypotheses are that employees will be less likely to report fraud when the organization fails to signal the presence of a positive ethical environment or when management reacts weakly to previous reports of unethical activity. The data and findings support these hypotheses. Additional testing also reveals that a psychological contract violation mediates the relationship between the outcome of previous reports and the intention to report fraud.Research limitations/implicationsAs with any experimental study, this study’s results come with limitations. Reading an overly simplistic scenario that omits real world details and providing intention to report is very different from actually reporting fraud in one’s own place of employment. Therefore, reporting intentions may vary from actual reporting behavior. Further, reporting motivation (self-defense, altruism, etc.) and concern over retaliation are not measured.Practical implicationsEmployees have expectations surrounding ethical corporate environments. Psychological contract violations occur as a result of broken expectations and are common in the workforce. In this study, a breakdown in the internal control environment because of a poor ethical culture, caused an even greater breakdown in internal controls because of employees’ decreased reporting intentions.Social implicationsPsychological contract violations impact employees’ intention to report fraud. These violations need to be understood so that additional measures and safeguards can be instituted when employees are not acting as a fraud defense or detection mechanism. During such times when there is a breakdown in this type of internal control (that is, when employees might be hesitant to report fraud), extra safeguards against fraud, additional procedures to detect fraud, and enhanced employee training encouraging reporting of suspected unethical conduct, become even more important.Originality/valueStrong experimental methods provide a rigorous way to evaluate a problem of our day: job insecurity caused by rampant organizational turbulence. The hidden cost is expressed in terms of how less can be expected of employees as a first line of defense against fraud.
Institutional quality and its impact on the facilitation of foreign direct investment
Authors: Chen Fuzhong , Jiang Guohai , Wang Wenting 
Published: November 2019

Purpose
Improvements in the facilitation of foreign direct investment (FDI) through institutional quality play a significant role in the establishment of an open economy. However, the impact of institutional quality on the facilitation of FDI along the Belt and Road countries is not well explored. This study aims to empirically investigate the influence of institutional quality on the degree of FDI facilitation and explore the impact mechanism using national-level panel data from countries along the Belt and Road.

Design/methodology/approach
For the data set, all variables have been normalized, and principal component analysis has been used. For the empirical models, robust standard errors and dynamic GMM method have been used to alleviate heteroscedasticity and endogeneity.

Findings
The empirical results indicate that institutional quality has a significantly positive effect on the degree of FDI facilitation. Furthermore, the impact mechanism involves the mediating mechanism. In other words, the effect of institutional quality that promotes FDI facilitation is influenced by factors such as laws and regulations. In addition, the implementation of the Belt and Road Initiative (BRI) has significantly enhanced the promotional effect of institutional quality on the facilitation of FDI.

Practical implications
Policymakers should focus on improving the institutional quality and the influence of mediating mechanisms, such as policies and regulations, in the institutional environment.

Originality/value
This study contributes to extant literature on the impact of institutional quality on FDI facilitation of significance to China, the BRI countries, and other countries to facilitate openness in international investment. This study also contributes to the extant literature on the influence of the BRI on the development of BRI countries. This will inform policy makers, investment institutions and enterprises about the development of effective policies to aid the development of BRI countries and improve the efficiency and the returns on FDI.
Moral literacy and school leadership
Authors: Lowery Charles 
Published: November 2019

PurposePublic interests and concerns often create dilemmas for school principals. As such moral dilemmas are the case for schools as places marked by social, economic, cultural and political diversity. The purpose of this paper is to look at how Appalachian school leaders use moral literacy to make decisions when facing ethical issues?Design/methodology/approachThe data for this study emerged from interviews conducted with ten principals. The principals interviewed represent a purposeful sample of practitioners within the Appalachian region of Southern Ohio, using group characteristic sampling.FindingsPrincipals’ responses varied in their depth of familiarity and comfort with moral literacy. The abductive analysis yielded several thematic units, classified using both emergent patterns anda prioricodes. The overarching themes that emerged from this analysis concerned what an ethical dilemma is, what it means to be a morally literate leader, moral dimensions of leadership, and the value integration of doing ethics and being ethical.Research limitations/implicationsThis study relies strictly on the participants’ personal conceptualization of moral literacy and the ethical paradigms it presupposes. As a qualitative study, the findings are based primarily on the participants’ perception of and the researcher’s interpretation of the complexities and ambiguities in reading ethical dilemmas.Practical implicationsTo effectively accomplish the moral work of the principalship requires that school leaders be morally literate, understanding the integrated nature of ethical paradigms.Originality/valueThe findings of this study continue to disclose the manner in which practicing principals define what an ethical dilemma is and moves us closer to understanding how practitioners frame moral literacy within their practice yet outside of exposure to clearly defined theoretical frameworks.
A high-speed world with fake news: brand managers take warning
Authors: Peterson Mark 
Published: November 2019

Purpose
In an increasingly dangerous era for brands because of the emergence of fake news on the internet, brand managers need to know what is happening with fake news. This study aims to present perspectives on how to cope in an era of fake news.

Design/methodology/approach
The author provides a general review of fake news and what its sudden rise means for brand managers.

Findings
The study highlights the importance of context for news and the role of institutions, such as businesses and governments. The study calls brand managers to slow down in the high-speed world of the infosphere to preserve the integrity of their brands.

Research limitations/implications
The study is limited by its time frame as the internet continues to evolve. However, for times when fake news presents a threat to brands and other institutions, the study is relevant.

Practical implications
Brand managers need to slow down their activity levels just as savvy readers need to slow down their own reading on the internet. By doing this, brand managers will be better able to defend their brands in an era characterized by volatility, uncertainty, complexity and ambiguity (VUCA).

Social implications
The study suggests that resistance to fake news and its pernicious effects can be improved by taking an approach to processing content on the internet characterized by the scientific method. In this way, a context for news can be derived and fake news can be identified. In this way, societal trust can be improved.

Originality/value
This study is original because it analyzes the implications of fake news for brand managers and presents the most workable steps for identifying fake news.
Visual storytelling and vulnerable health care consumers: normalising practices and social support through Instagram
Authors: Gurrieri Lauren , Drenten Jenna 
Published: November 2019

Purpose
The purpose of this study is to explore how vulnerable healthcare consumers foster social support through visual storytelling in social media in navigating healthcare consumption experiences.

Design/methodology/approach
This study employs a dual qualitative approach of visual and textual analysis of 180 Instagram posts from female breast cancer patients and survivors who use the platform to narrate their healthcare consumption experiences.

Findings
This study demonstrates how visual storytelling on social media normalises hidden aspects of healthcare consumption experiences through healthcare disclosures (procedural, corporeal, recovery), normalising practices (providing learning resources, cohering the illness experience, problematising mainstream recovery narratives) and enabling digital affordances, which in turn facilitates social support among vulnerable healthcare consumers.

Practical implications
This study highlights the potential for visual storytelling on social media to address shortcomings in the healthcare service system and contribute to societal well-being through co-creative efforts that offer real-time and customised support for vulnerable healthcare consumers.

Social implications
This research highlights that visual storytelling on image-based social media offers transformative possibilities for vulnerable healthcare consumers seeking social support in negotiating the challenges of their healthcare consumption experiences.

Originality/value
This study presents a framework of visual storytelling for vulnerable healthcare consumers on image-based social media. Our paper offers three key contributions: that visual storytelling fosters informational and companionship social support for vulnerable healthcare consumers; recognising this occurs through normalising hidden healthcare consumption experiences; and identifying healthcare disclosures, normalising practices and enabling digital affordances as fundamental to this process.
Using social media to explore regional cuisine preferences in China
Authors: Zhang Chengzhi , Yue Zijing , Zhou Qingqing , Ma Shutian , Zhang Zi-Ke 
Published: November 2019

Purpose
Food plays an important role in every culture around the world. Recently, cuisine preference analysis has become a popular research topic. However, most of these studies are conducted through questionnaires and interviews, which are highly limited by the time, cost and scope of data collection, especially when facing large-scale survey studies. Some researchers have, therefore, attempted to mine cuisine preferences based on online recipes, while this approach cannot reveal food preference from people’s perspective. Today, people are sharing what they eat on social media platforms by posting reviews about the meal, reciting the names of appetizers or entrees, and photographing as well. Such large amount of user-generated contents (UGC) has potential to indicate people’s preferences over different cuisines. Accordingly, the purpose of this paper is to explore Chinese cuisine preferences among online users of social media.

Design/methodology/approach
Based on both UGC and online recipes, the authors first investigated the cuisine preference distribution in different regions. Then, dish preference similarity between regions was calculated and few geographic factors were identified, which might lead to such regional similarity appeared in our study. By applying hierarchical clustering, the authors clustered regions based on dish preference and ingredient usage separately.

Findings
Experimental results show that, among 20 types of traditional Chinese cuisines, Sichuan cuisine is most favored across all regions in China. Geographical proximity is the more closely related to differences of regional dish preference than climate proximity.

Originality/value
Different from traditional definitions of regions to which cuisine belong, the authors found new association between region and cuisine based on dish preference from social media and ingredient usage of dishes. Using social media may overcome problems with using traditional questionnaires, such as high costs and long cycle for questionnaire design and answering.
Charting a path forward in student success
Authors: Deeken Lynn , Vecchione Amy , Carr Allison , Hallman Shelby , Herzellah Lara , Lopez Natalia , Rucker Rob , Alfieri Michael , Tenofsky Deborah , Moore Anne , Fawley Nancy , Glover John , Peacemaker Bettina , Pajewski Amy 
Published: November 2019

Purpose
This paper aims to demonstrate the variety of ways institutions and their libraries approach student success both conceptionally and operationally.

Design/methodology/approach
Librarians from eight different institutions of higher education were given a series of questions about student success on their campuses and in their libraries. They responded with written essays describing their experiences and perspectives.

Findings
The contributed pieces in this second installment are collected together and a variety of ways the academic library engage with “student success” are discussed. Initiatives include high-impact practices, fostering academic rapport and creating a sense of belonging, experiential learning and creative spaces and professional development.

Originality/value
These examples help to observe what is happening throughout higher education and see potential paths forward at the institutions engaged in this work.