bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteonecrosis of femoral head in young patients with femoral neck fracture: a retrospective study of 250 patients followed for average of 7.5 years
Authors: Pei Fang , Zhao Rui , Li Fenglei , Chen Xiangyang , Guo KaiJin , Zhu Liang 
Published: June 2020

AbstractObjectiveTo investigate the risk factors for osteonecrosis of the femoral head (ONFH) after the treatment of femoral neck fracture in patients under 60 years old.MethodsA total of 250 cases of femoral neck fracture treated at 3 hospitals in Xuzhou from January 2002 to January 2016 were studied. The patients were followed up for 1~15 years, and the clinical data on femoral head necrosis after the femoral neck operation were analysed retrospectively. Risk factors were recorded, including age, gender, preoperative traction, time from injury to operation, reduction method, type of reduction, BMI, ASA classification, and quality of reduction. Logistic regression analysis was used to evaluate the independent risk factors for ONFH after treatment of femoral neck fracture.ResultsThe duration of follow-up was 1~15 years, with an average of 7.5 years. None of the 250 patients had fracture non-union, but 40 (16%) had necrosis of the femoral head. The time to necrosis of the femoral head was 1~7 years after the operation, with an average of 3.8 years. Univariate analysis showed that the type of fracture, the quality of reduction, the removal of internal fixation, BMI and ASA classification were risk factors affecting necrosis of the femoral head in patients with femoral neck fracture, and the difference was statistically significant (P< 0.05). Multivariate analysis showed that internal fixation, fracture type (displacement), reduction quality (dissatisfaction), BMI (> 25), and ASA grade (III + IV) were independent risk factors affecting femoral head necrosis in patients with femoral neck fracture.ConclusionA variety of high-risk factors for femoral head necrosis are present after surgery with hollow compression screws for femoral neck fracture in adults. Removal of internal fixation, type of fracture, quality of reduction, BMI, and ASA classification were the most important risk factors influencing the development of femoral head necrosis. During treatment, there should be some targeted measures to reduce the incidence of necrosis of the femoral head.
Association between institutional case volume and mortality following thoracic aorta replacement: a nationwide Korean cohort study
Authors: Nam Karam , Jang Eun Jin , Jo Jun Woo , Choi Jae Woong , Lee Minkyoo , Ryu Ho Geol 
Published: June 2020

Abstract
Background
The inverse relationship between case volume and postoperative mortality following high-risk surgical procedures have been reported. Thoracic aorta surgery is associated with one of the highest postoperative mortality. The relationship between institutional case volume and postoperative mortality in patients undergoing thoracic aorta replacement surgery was evaluated.

Methods
All thoracic aorta replacement surgeries performed in Korea between 2009 and 2016 in adult patients were analyzed using an administrative database. Hospitals were divided into low (< 30 cases/year), medium (30–60 cases/year), or high (> 60 cases/year) volume centers depending on the annual average number of thoracic aorta replacement surgeries performed. The impact of case volume on in-hospital mortality was assessed using the logistic regression.

Results
Across 83 hospitals, 4867 cases of thoracic aorta replacement were performed. In-hospital mortality was 8.6% (191/2222), 10.7% (77/717), and 21.9% (422/1928) in high, medium, and low volume centers, respectively. The adjusted risk of in-hospital mortality was significantly higher in medium (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.16–2.11, P = 0.004) and low volume centers (OR, 3.12; 95% CI, 2.54–3.85, P < 0.001) compared to high volume centers.

Conclusions
Patients who had underwent thoracic aorta replacement surgery in lower volume centers had increased risk of in-hospital mortality after surgery compared to those in higher volume centers. Our results may provide the basis for minimum case volume requirement or regionalization in thoracic aorta replacement surgery for optimal patient outcome.
Comparison of dual antiplatelet therapies after coronary endarterectomy combined with coronary artery bypass grafting: a cohort study
Authors: Yan Hua , Tiemuerniyazi Xieraili , Song Yangwu , Xu Fei , Feng Wei 
Published: June 2020

Abstract
Background
Coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) can be the only option for complete revascularization in some patients with diffuse coronary artery disease. Unfortunately, CE can cause the lack of endothelium, resulting in increased risk of thrombotic events. Therefore, antithrombotic therapy is very important after surgery. However, there’s no consistent protocol exists till now. The aim of this study was to compare the effectiveness and safety of dual antiplatelet therapies (DAPT) including aspirin plus clopidogrel (AC) or ticagrelor (AT) after CE + CABG.

Method
A total of 137 continuous patients (mean age 60.0 ± 9.0 years) underwent CE + CABG from January 2016 to July 2018 in our center, and patients who received dual antiplatelet therapy (DAPT) after surgery (n = 121) were included in this study. All of the patients received aspirin 100 mg daily therapy after surgery, and 67 of the patients received extra clopidogrel 75 mg (AC) daily therapy, whereas 54 received extra ticagrelor 90 mg (AT) twice daily. All patients continued aspirin monotherapy after 1 year. Occurrence of ischemic events and bleeding events between two groups were compared. Kaplan-Meier survival was used to compare freedom from major adverse cardiovascular and cerebrovascular events (MACCE) between two groups, and log-rank test was used to confirm statistical difference.

Results
Follow-up was completed by 99.2%, and median follow-up time was 30.0(22.5, 35.2) months. No operative death was observed, while perioperative myocardial infarction was observed in 2(1.7%) patients (AC 1.5% vs. AT 1.9%, p = ns). One patient in AC group suffered from cardiac tamponade. During the follow-up period, no death was observed. Ischemic events including nonfatal myocardial infarction, repeat revascularization and ischemic stroke were observed in 6(5.0%) patients (AC 4.5% vs. AT 5.6%, p = ns). Overt bleeding had occurred in 3(2.5%) patients (AC 3.0% vs. AT 1.9%, p = ns). Kaplan-Meier analysis indicated that MACCE-free survival of the two groups at 3 years was 97.0% in the AC group versus 94.1% in the AT group (p = ns).

Conclusion
In patients undergoing CE + CABG, DAPT therapy can be effective and safe with comparable results between AC and AT therapy in terms of ischemic and bleeding events. Further studies are needed.
PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim
Authors: Byerly Jessica H. , Port Elisa R. , Irie Hanna Y. 
Published: June 2020

Abstract
Background
Protein kinase C theta, (PRKCQ/PKCθ) is a serine/threonine kinase that is highly expressed in a subset of triple-negative breast cancers (TNBC) and promotes their growth, anoikis resistance, epithelial-mesenchymal transition (EMT), and invasion. Here, we show that PRKCQ regulates the sensitivity of TNBC cells to apoptosis triggered by standard-of-care chemotherapy by regulating levels of pro-apoptotic Bim.

Methods
To determine the effects of PRKCQ expression on chemotherapy-induced apoptosis, shRNA and cDNA vectors were used to modulate the PRKCQ expression in MCF-10A breast epithelial cells or triple-negative breast cancer cells (MDA-MB231Luc, HCC1806). A novel PRKCQ small-molecule inhibitor, 17k, was used to inhibit kinase activity. Viability and apoptosis of cells treated with PRKCQ cDNA/shRNA/inhibitor +/-chemotherapy were measured. Expression levels of Bcl2 family members were assessed.

Results
Enhanced expression of PRKCQ is sufficient to suppress apoptosis triggered by paclitaxel or doxorubicin treatment. Downregulation of PRKCQ also enhanced the apoptosis of chemotherapy-treated TNBC cells. Regulation of chemotherapy sensitivity by PRKCQ mechanistically occurs via regulation of levels of Bim, a pro-apoptotic Bcl2 family member; suppression of Bim prevents the enhanced apoptosis observed with combined PRKCQ downregulation and chemotherapy treatment. Regulation of Bim and chemotherapy sensitivity is significantly dependent on PRKCQ kinase activity; overexpression of a catalytically inactive PRKCQ does not suppress Bim or chemotherapy-associated apoptosis. Furthermore, PRKCQ kinase inhibitor treatment suppressed growth, increased anoikis and Bim expression, and enhanced apoptosis of chemotherapy-treated TNBC cells, phenocopying the effects of PRKCQ downregulation.

Conclusions
These studies support PRKCQ inhibition as an attractive therapeutic strategy and complement to chemotherapy to inhibit the growth and survival of TNBC cells.
A novel C-terminal degron identified in bacterial aldehyde decarbonylases using directed evolution
Authors: Liu Yilan , Chen Jinjin , Khusnutdinova Anna N. , Correia Kevin , Diep Patrick , Batyrova Khorcheska A. , Nemr Kayla , Flick Robert , Stogios Peter , Yakunin Alexander F. , Mahadevan Radhakrishnan 
Published: June 2020

AbstractBackgroundAldehyde decarbonylases (ADs), which convert acyl aldehydes into alkanes, supply promising solution for producing alkanes from renewable feedstock. However the instability of ADs impedes their further application. Therefore, the current study aimed to investigate the degradation mechanism of ADs and engineer it towards high stability.ResultsHere, we describe the discovery of a degradation tag (degron) in the AD from marine cyanobacteriumProchlorococcus marinususing error-prone PCR-based directed evolution system. Bioinformatic analysis revealed that this C-terminal degron is common in bacterial ADs and identified a conserved C-terminal motif, RMSAYGLAAA, representing the AD degron (ADcon). Furthermore, we demonstrated that the ATP-dependent proteases ClpAP and Lon are involved in the degradation of AD-tagged proteins inE. coli, thereby limiting alkane production. Deletion or modification of the degron motif increased alkane production in vivo.ConclusionThis work revealed the presence of a novel degron in bacterial ADs responsible for its instability. The in vivo experiments proved eliminating or modifying the degron could stabilize AD, thereby producing higher titers of alkanes.
Serious infections in people with systemic sclerosis: a national US study
Authors: Singh Jasvinder A. , Cleveland John D. 
Published: June 2020

Abstract
Objective
To study incidence, time trends, and outcomes of serious infections in systemic sclerosis (SSc).

Methods
We used the 1998–2016 US National Inpatient Sample data. We examined the epidemiology, time trends, and outcomes of five serious infections (opportunistic infections (OI), skin and soft tissue infections (SSTI), urinary tract infection (UTI), pneumonia, and sepsis/bacteremia) in hospitalized people with SSc. We performed multivariable-adjusted logistic regression analyses to analyze independent association of factors with healthcare utilization (hospital charges, length of hospital stay, discharge to non-home setting) and in-hospital mortality.

Results
There were 49,904,955 hospitalizations with serious infections in people without SSc and 61,615 in those with SSc. During 1998–2016, the most common serious infections in SSc were pneumonia (45%), sepsis (32%), SSTI (19%), UTI (3%), and OI (3%). In 2013–2014, sepsis surpassed pneumonia as the most common serious infection; by 2015–2016, sepsis was 1.8 times more common than pneumonia. Over the study period, hospital charges increased, while length of hospital stay and in-hospital mortality decreased, overall and for each serious infection. Multivariable-adjusted analyses showed that sepsis, age ≥ 80 years, and Deyo-Charlson score ≥ 2 were associated with significantly higher odds of healthcare utilization and in-hospital mortality, and Medicare or Medicaid insurance payer, Northeast location, urban teaching or non-teaching hospital, and medium or large hospital bed size with significantly higher odds of healthcare utilization.

Conclusions
Outcomes in people with SSc hospitalized with serious infections have improved over time, except higher hospital charges. Identification of factors associated with higher healthcare utilization and in-hospital mortality allows for developing interventions to improve outcomes.
Development of a multivariable improvement measure for gout
Authors: Schlesinger Naomi , Edwards N. Lawrence , Yeo Anthony E. , Lipsky Peter E. 
Published: June 2020

Abstract
Background
Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.

Methods
Results from patients treated with pegloticase or placebo in two randomized clinical trials and their open-label extension were assessed using a novel evidence-based Gout Multivariable Improvement Measure (GMIM) derived from previously reported criteria for remission and complete response. Improvement was defined as serum urate (sU) < 6 mg/dL and absence of flares during the preceding 3 months plus 20, 50, and 70% improvement in tophus size, patient global assessment, pain, and swollen and tender joints.

Results
Patients treated with pegloticase manifested a significantly greater GMIM20, 50, and 70 response vs those treated with placebo (GMIM20 at 6 months 37.1% vs 0%, respectively). Higher response rates were significantly more frequent in subjects with persistent urate lowering (GMIM 58.1% at 6 months) in response to pegloticase versus those with only transient urate lowering (GMIM 7.1% at 6 months). However, when the requirement for a decrease in sU to < 6 mg/dL was omitted, a substantial percentage of subjects with transient urate lowering met the GMIM clinical criteria. A sensitivity analysis indicated that gout flares contributed minimally to the model. The response measured by GMIM persisted into the open-level extension for as long as 2 years. Finally, subjects who received placebo in the randomized control trials, but pegloticase in the open-label extension, manifested GMIM responses comparable to that noted with pegloticase-treated subjects in the randomized controlled trials.

Conclusions
GMIM captures changes in disease activity in response to treatment with pegloticase and may serve as an evidence-based tool for assessment of responses to other urate-lowering therapies in gout patients.
Research on simulation of school uniform supply chain optimal model based on internet of things
Authors: Jun Chen 
Published: June 2020

AbstractIn this paper, the information sharing platform based on the Internet of things is constructed to improve the efficiency of supply chain, and the flow chart based on the Internet of things of the school uniform is analyzed, integrated application of Internet of things technology in supply chain to analyze the detail of the system. By calculating Lyapunov Index, power spectrum, and correlation dimension, the bifurcation and chaos characteristics of supply chain under different production strategies are analyzed. At the same time, the periodicity and initial value sensitivity of chaos are used to explain the feasibility of manufacturer organizing flexible production and the causes of bullwhip effect in supply chain and corresponding prevention measures. And the experiment results show that bullwhip effect will occur in the chaotic supply chain system, which can be suppressed by short-term forecasting and accelerating the speed of demand information transmission. Chaos also has a favorable side for enterprises, such as making low-cost flexible production possible.
Automatic registration method using EM sensors in the IoT operating room
Authors: Lin Qinyong , Yang Rongqian , Dai Zhiyu , Chen Huazhou , Cai Ken 
Published: June 2020

AbstractThe Internet of Things (IoT) in the operating room can aid to improve the quality of the computer-aided surgical system. Patient-to-image registration is an important issue for computer-aided surgical systems. Automating the procedure of patient-to-image registration could increase tracking accuracy and lower the time consumed for performing the procedure of registration. Therefore, we propose an automatic registration method to address this issue by constructing a wireless sensor network system for surgery. A plastic fiducial object combing with specific markers is developed to perform registration in that the ultimate purpose is to integrate them into a surgical robotic system for surgical navigation. The specific markers are designed to localize the position of the small EM sensor and can be automatically detected in CT/MRI images by an automatic algorithm. The positions of the EM tracking sensors can be calibrated during the procedure of registration. Some experiments are designed and performed, and the experimental results demonstrate that the proposed registration method is robust and accurate. The proposed registration method is a foundational link of the surgical robots combing with virtual or augmented reality technology that all these technologies will be performed in further surgical navigation.
Generalizations of Ostrowski type inequalities via Hermite polynomials
Authors: Kvesić Ljiljanka , Pečarić Josip , Ribičić Penava Mihaela 
Published: June 2020

AbstractWe present new generalizations of the weighted Montgomery identity constructed by using the Hermite interpolating polynomial. The obtained identities are used to establish new generalizations of weighted Ostrowski type inequalities for differentiable functions of class $C^{n}$

C
n

. Also, we consider new bounds for the remainder of the obtained identities by using the Chebyshev functional and certain Grüss type inequalities for this functional. By applying those results we derive inequalities for the class of n-convex functions.
New generalized reverse Minkowski and related integral inequalities involving generalized fractional conformable integrals
Authors: Rashid Saima , Akdemir Ahmet Ocak , Nisar Kottakkaran Sooppy , Abdeljawad Thabet , Rahman Gauhar 
Published: June 2020

AbstractThis paper gives some novel generalizations by considering the generalized conformable fractional integrals operator for reverse Minkowski type and reverse Hölder type inequalities. Furthermore, novel consequences connected with this inequality, together with statements and confirmation of various variants for the advocated generalized conformable fractional integral operator, are elaborated. Moreover, our derived results are provided to show comparisons of convergence between old and modified operators towards a function under different parameters and conditions. The numerical approximations of our consequence have several utilities in applied sciences and fractional integro-differential equations.
Dynamic of interactive model for information propagation across social networks media
Authors: Zhang Yaming , Liu Fei , Koura Yaya H. , Wang Hao 
Published: June 2020

AbstractControlling information diffusion or propagation through social networks can be challenging when dealing with information related to a subject of highest interest for the public. The complexity level of control depends on subject importance, users’ dynamic, and network structure. When two published messages or pieces of information share the same interest for targeted readers, analyzing their propagation dynamic for control and prediction is of great interest. This article proposes to model, based on a modified interactive system with Holling type functional response, the dynamic of underlying relationship between two broadcasted messages traveling through social networks media. We showed in the qualitative analysis of the proposed model that system could be stable at certain conditions, and the model-system exhibited very rich dynamical behavior. Numerical simulation results validated theoretical analyses and suggested adapting resources harvesting and assimilation efficiency for an authoritative message to stabilize the system and control the dissemination of information in a closed environment.
Detection of arrhythmia using an implantable cardiac monitor following a cryptogenic stroke: a single-center observational study
Authors: Öner Alper , Lips Thomas , Walter Uwe , Storch Alexander , Ince Hüseyin , Caglayan Evren , Yücel Seyrani , Ortak Jasmin , Schmidt Christian 
Published: June 2020

Abstract
Background
Detection of atrial fibrillation (AF) after cryptogenic stroke (CS) has therapeutic implications, but the most effective type and optimal duration of monitoring have still to be defined. This study that involved patients with CS or transient ischemic attack (TIA), all of whom carried an implantable cardiac monitor (ICM), sought to assess the incidence of AF and other arrhythmia detected using tele-monitoring or interval-based follow-up by an internal cardiologist at the university medical center of Rostock (UMR) or an external cardiologist.

Methods
The ICM implantation was performed during the inpatient stay in the neurology department, with inclusion and exclusion criteria jointly determined by the neurology and cardiology departments. Cardiologists programmed individual threshold values during ICM implantation, which were designed to instantly trigger an episode being recording and an alarm message being sent out. Outpatient care consisted of tele-monitoring of implants or interval-based follow-up care.

Results
The indication for ICM implantation was made for 102 patients, 88 of whom underwent ICM implantation, with full documentation available for these 88 study patients. Within a median observation period of 21.5 months, AF occurred in 19 patients, with a median observation time to the event of 7 months. In all cases, AF detection was followed by immediate medical intervention. Comparing patients with and without AF revealed that the median age of the AF group exceeded by 10 years that of the other patients. Stroke recurrence was recorded in five patients, with a median observation time to the event of 9 months. Comparing patients with and without stroke recurrence revealed that the median age in the stroke recurrence group tended to be higher by 14 years. No statistically significant between-group differences were found with regard to integration into tele-monitoring, nor were there any differences identified between outpatient care at the UMR or in the outpatient sector.

Conclusions
This study confirmed the feasibility of using an interdisciplinary and intersectoral therapeutic approach for monitoring CS patients with implanted ICMs. Further randomized studies are warranted to confirm these encouraging data. An open discussion concerning optimal care forms and opportunities for introducing digitizing care pathways appears warranted.