bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal endoscopic tracheal occlusion reverses the natural history of right‐sided congenital diaphragmatic hernia: European multicenter experience
Authors: Russo F. M. , Cordier A.‐G. , Basurto D. , Salazar L. , Litwinska E. , Gomez O. , Debeer A. , Nevoux J. , Patel S. , Lewi L. , Pertierra A. , Aertsen M. , Gratacos E. , Nicolaides K. H. , Benachi A. , Deprest J. 
Published: September 2020

ABSTRACTObjectiveTo evaluate the neonatal outcome of fetuses with isolated right‐sided congenital diaphragmatic hernia (iRCDH) based on prenatal severity indicators and antenatal management.MethodsThis was a retrospective review of prospectively collected data on consecutive cases diagnosed with iRCDH before 30 weeks' gestation in four fetal therapy centers, between January 2008 and December 2018. Data on prenatal severity assessment, antenatal management and perinatal outcome were retrieved. Univariate and multivariate logistic regression analysis were used to identify predictors of survival at discharge and early neonatal morbidity.ResultsOf 265 patients assessed during the study period, we excluded 40 (15%) who underwent termination of pregnancy, two cases of unexplained fetal death, two that were lost to follow‐up, one for which antenatal assessment of lung hypoplasia was not available and six cases which were found to have major associated anomalies or syndromes after birth. Of the 214 fetuses with iRCDH included in the neonatal outcome analysis, 86 were managed expectantly during pregnancy and 128 underwent fetal endoscopic tracheal occlusion (FETO) with a balloon. In the expectant‐management group, lung size measured by ultrasound or by magnetic resonance imaging was the only independent predictor of survival (observed‐to‐expected lung‐to‐head ratio (o/e‐LHR) odds ratio (OR), 1.06 (95% CI, 1.02–1.11); P = 0.003). Until now, stratification for severe lung hypoplasia has been based on an o/e‐LHR cut‐off of 45%. In cases managed expectantly, the survival rate was 15% (4/27) in those with o/e‐LHR ≤ 45% and 61% (36/59) for o/e‐LHR > 45% (P = 0.001). However, the best o/e‐LHR cut‐off for the prediction of survival at discharge was 50%, with a sensitivity of 78% and specificity of 72%. In the expectantly managed group, survivors with severe pulmonary hypoplasia stayed longer in the neonatal intensive care unit than did those with mildly hypoplastic lungs. In fetuses with an o/e‐LHR ≤ 45% treated with FETO, survival rate was higher than in those with similar lung size managed expectantly (49/120 (41%) vs 4/27 (15%); P = 0.014), despite higher prematurity rates (gestational age at birth: 34.4 ± 2.7 weeks vs 36.8 ± 3.0 weeks; P < 0.0001). In fetuses treated with FETO, gestational age at birth was the only predictor of survival (OR, 1.25 (95% CI, 1.04–1.50); P = 0.02).ConclusionsAntenatal measurement of lung size can predict survival in iRCDH. In fetuses with severe lung hypoplasia, FETO was associated with a significant increase in survival without an associated increase in neonatal morbidity. © 2020 International Society of Ultrasound in Obstetrics and Gynecology
Thiamine deficiency in a dog associated with exclusive consumption of boiled sweet potato (Ipomoea batatas): Serial changes in clinical findings, magnetic resonance imaging findings and blood lactate and thiamine concentrations
Authors: Song Joong‐Hyun , Jung Dong‐In 
Published: September 2020

AbstractThiamine (vitamin B1) is an essential nutrient that significantly influences ATP production in the body. It needs to be supplemented consistently through an exogenous source to prevent deficiency; however, it is easily affected by a variety of mitigating factors. Additionally, thiamine requirements can be influenced by an individual's dietary composition. The nervous system is particularly vulnerable to thiamine deficiency due to its high metabolic demand. Thiamine deficiency is typically diagnosed based on clinical signs, dietary history and response to thiamine administration. A 5‐year‐old neutered male Maltese Terrier dog presented with an acute onset of seizures and generalized ataxia. The dog was exclusively fed boiled sweet potato (Ipomoea batatas) as a primary diet source for 4 weeks. MR findings and hyperlactatemic conditions were consistent with thiamine deficiency, and the diagnosis was confirmed by measuring thiamine concentrations in blood using high‐performance liquid chromatography (HPLC). Appropriate thiamine supplementation and diet changes resulted in a rapid improvement in neurological signs. Repeated MR imaging 2 weeks after starting the treatment completely resolved the previously identified abnormalities, and repeated measurements of blood lactate and thiamine levels revealed complete recovery of the thiamine‐deficient status.
Glacio‐hydrological model calibration and evaluation
Authors: van Tiel Marit , Stahl Kerstin , Freudiger Daphné , Seibert Jan 
Published: September 2020

AbstractGlaciers are essential for downstream water resources. Hydrological modeling is necessary for a better understanding and for future projections of the water resources in these rapidly changing systems, but modeling glacierized catchments is especially challenging. Here we review a wealth of glacio‐hydrological modeling studies (145 publications) in catchments around the world. Major model challenges include a high uncertainty in the input data, mainly precipitation, due to scarce observations. Consequently, the risk of wrongly compensating input with model errors in competing snow and ice accumulation and melt process parameterization is particularly high. Modelers have used a range of calibration and validation approaches to address this issue. The review revealed that while a large part (~35%) of the reviewed studies used only streamflow data to evaluate model performances, most studies (~50%) have used additional data related to snow and glaciers to constrain model parameters. These data were employed in a variety of calibration strategies, including stepwise and multi‐signal calibration. Although the primary aim of glacio‐hydrological modeling studies is to assess future climate change impacts, long‐term changes have rarely been taken into account in model performance evaluations. Overall, a more precise description of which data are used how for model evaluation would facilitate the interpretation of the simulation results and their uncertainty, which in turn would support water resources management. Moreover, there is a need for systematic analyses of calibration approaches to disentangle what works best and why. Addressing this need will improve our system understanding and model simulations of glacierized catchments.This article is categorized under:
Science of Water > Hydrological Processes
Science of Water > Methods
Conservation medicine and One Health in zoos: Scope, obstacles, and unrecognized potential
Authors: Sulzner Kate , Fiorello Christine , Ridgley Frank , Garelle Della , Deem Sharon L. 
Published: September 2020

AbstractZoo veterinarians and allied professionals have been contributing to conservation medicine (CM) and One Health (OH) activities for more than two decades. Although the Association of Zoos and Aquariums (AZA) considers conservation a key part of its mission, little published material exists about the extent of AZA work in CM/OH or the challenges and opportunities associated with these endeavors. To better understand the current scope of CM/OH in zoos, we surveyed 53 AZA‐accredited institutions from April through October of 2016. We obtained information on CM/OH infrastructure, support for expansion in this area, and strategies to overcome perceived obstacles hindering CM/OH from becoming a core AZA activity. Survey results revealed that while most zoos favor greater investment in CM/OH programs, awareness, and understanding of CM/OH across the broader zoo community and public is lacking. The majority of respondents stated that overcoming this challenge is paramount to attaining support for CM/OH initiatives. In spite of these obstacles, survey respondents highlighted many positive developments in CM/OH. We found that 84% of zoos surveyed are actively engaged in CM/OH activities, and 12% house formal CM/OH programs. Another 8% of respondents said their institutions were developing CM/OH programs. Perhaps most noteworthy, we found that zoo size did not have a significant bearing on the financial amount allocated toward an institution's CM/OH activities. This suggests that all zoos, regardless of size, can make meaningful contributions to the growing movement of CM/OH and help redefine the role of zoos within this movement.
An Approach for Software-Intensive Business Innovation Based on Experimentation in Non-software-Intensive Companies
Authors: Silva Kelson , Guerra Eduardo , Melegati Jorge 
Published: September 2020

Abstract
Several companies whose businesses are not centered on technology might fail to innovate and get advantages over their competitors. For them, meaningful innovations are not necessarily related to the usage of new technologies but the optimization of some business process. In the literature, experimentation is described as an essential aspect of the innovation process. Although software engineering studies have explored experimentation, none has focused on software-intensive innovative projects in non-software-intensive companies, which consists of a contrast between the fast-changing environment in software-intensive to rigid structures in consolidated businesses. This paper proposes an experiment-oriented process to identify and implement innovation in this kind of company, including the roles involved in such processes. It has steps to identify business bottlenecks, search for solution alternatives, implement a fast and functional software proof of concept, create a plan for evolution, and migrate to a regular project to continue that idea. This paper also presents an evaluation of this process in a company focused on outsourced services, such as cleaning and maintenance. As a result, several internal procedures in a year were improved and received software support.
A Systematic Approach to Agile Development in Highly Regulated Environments
Authors: Poth Alexander , Jacobsen Jan , Riel Andreas 
Published: September 2020

AbstractFor established domains within highly regulated environments, a systematic approach is needed to scale agile methods and assure compliance with regulatory requirements. The presented approach works adequately in small agile teams – independently of the underlying method such as Scrum, Kanban, etc. – and is scalable to more and bigger teams or even entire subsidiaries. It is based on a compliance and a quality risk dimension respectively. Both dimensions are needed to fit regulatory requirements in our finance example with more than 100 developers in one subsidiary.
Dependencies of Agile Teams – An Analysis of the Scaled Agile Framework
Authors: Theobald Sven , Schmitt Anna 
Published: September 2020

Abstract
Context: Agile teams are small teams with 3 to 9 members. In complex development endeavors such as systems engineering, an agile team has many dependencies, since it is not possible to incorporate all specialist skills into one team. Frameworks like the Scaled Agile Framework (SAFe) describe how agile teams operate in a larger setting. Objective: The aim of this study is to analyze how agile teams collaborate with their organizational environment. Method: We analyzed SAFe to investigate how much guidance it provides concerning the collaboration between agile teams and their environment. Results: The results show that many different organizational parts exist with which agile teams have to collaborate. SAFe mentions concepts like shared services, system teams, or business teams, but there is no further guidance on collaboration with the agile team. Conclusion: We motivate future research into guidelines for efficient collaboration of agile teams with their organizational environment.
COVID-19’s Influence on the Future of Agile
Authors: Mancl Dennis , Fraser Steven D. 
Published: September 2020

Abstract
As a result of the global COVID-19 pandemic, the way the world works, collaborates, and plays has changed. Commerce has stalled with travel, hospitality, education, retail, and health sectors particularly affected. This paper is based on an XP 2020 panel organized by Steven Fraser and featuring Aino Corry, Steve McConnell, and Rachel Reinitz. The panel discussed the impact of COVID-19 on knowledge workers, the acceleration of digital workplace transformation, and anticipated long term effects from the pandemic in the context of agile practices. Four key observations emerged from the discussion: First, virtual collaboration between those working from home is enabled by a variety of communication tools – substituting for face-to-face interactions. Second, agile work practices are harder to perform given the virtual nature of meetings and interactions. Third, communication tools are not always adequate for high-bandwidth or informal interactions, such as brainstorming, side discussions, or hallway conversations. Fourth, forming new teams and onboarding staff is challenging in a virtual work environment.
Product Roadmap Alignment – Achieving the Vision Together: A Grey Literature Review
Authors: Trieflinger Stefan , Münch Jürgen , Bogazköy Emre , Eißler Patrick , Schneider Jan , Roling Bastian 
Published: September 2020

Abstract
Context: A product roadmap is an important tool in product development. It sets the strategic direction in which the product is to be developed to achieve the company’s vision. However, for product roadmaps to be successful, it is essential that all stakeholders agree with the company’s vision and objectives and are aligned and committed to a common product plan. Objective: In order to gain a better understanding of product roadmap alignment, this paper aims at identifying measures, activities and techniques in order to align the different stakeholders around the product roadmap. Method: We conducted a grey literature review according the guidelines to Garousi et al. Results: Several approaches to gain alignment were identified such as defining and communicating clear objectives based on the product vision, conducting cross-functional workshops, shuttle diplomacy, and mission briefing. In addition, our review identified the “Behavioural Change Stairway Model” that suggests five steps to gain alignment by building empathy and a trustful relationship.
Transitioning from a First Generation to Second Generation Large-Scale Agile Development Method: Towards Understanding Implications for Coordination
Authors: Bjørnson Finn Olav , Dingsøyr Torgeir 
Published: September 2020

Abstract

This paper reports our initial findings from a longitudinal case study within a large development project in a public organization in Scandinavia. We focus on changes in coordination practices as the development project moved from a 1st to a 2nd generation large-scale agile development methodology. Building on four theories of coordination from different fields, we investigate how each theory illuminates our case and what insight they might provide. We find that two of the theories are well suited to characterizing each phase, providing answer to how coordination was done. While two other theories can provide answers to why these changes occurred.
Bilateral Looser zones or pseudofractures in the anteromedial tibia as a component of medial tibial stress syndrome in athletes
Authors: Stürznickel Julian , Jandl Nico Maximilian , Delsmann Maximilian M. , von Vopelius Emil , Barvencik Florian , Amling Michael , Ueblacker Peter , Rolvien Tim , Oheim Ralf 
Published: September 2020

AbstractPurposeMedial tibial stress syndrome (MTSS) represents a common diagnosis in individuals exposed to repetitive high-stress loads affecting the lower limb, e.g., high-performance athletes. However, the diagnostic approach and therapeutic regimens are not well established.MethodsNine patients, diagnosed as MTSS, were analyzed by a comprehensive skeletal analysis including laboratory bone turnover parameters, dual-energy X-Ray absorptiometry (DXA), and high-resolution peripheral quantitative computed tomography (HR-pQCT).ResultsIn 4/9 patients, bilateral pseudofractures were detected in the mid-shaft tibia. These patients had significantly lower levels of 25-hydroxycholecalciferol compared to patients with MTSS but similar levels of bone turnover parameters. Interestingly, the skeletal assessment revealed significantly higher bone mineral density (BMD) Z-scores at the hip (1.3 ± 0.6 vs. − 0.7 ± 0.5,p = 0.013) in patients with pseudofractures and a trend towards higher bone microarchitecture parameters measured by HR-pQCT at the distal tibia. Vitamin D supplementation restored the calcium-homeostasis in all patients. Combined with weight-bearing as tolerated, pseudofractures healed in all patients and return to competition was achieved.ConclusionIn conclusion, deficient vitamin D levels may lead to pseudofractures due to localized deterioration of mineralization, representing a pivotal component of MTSS in athletes with increased repetitive mechanical loading of the lower limbs. Moreover, the manifestation of pseudofractures is not a consequence of an altered BMD nor microarchitecture but appears in patients with exercise-induced BMD increase in combination with reduced 25-OH-D levels. The screening of MTSS patients for pseudofractures is crucial for the initiation of an appropriate treatment such as vitamin D supplementation to prevent a prolonged course of healing or recurrence.Level of evidenceIII.
An issue based power index
Authors: Kong Qianqian , Peters Hans 
Published: September 2020

AbstractAn issue game is a combination of a monotonic simple game and an issue profile. An issue profile is a profile of linear orders on the player set, one for each issue within the set of issues: such a linear order is interpreted as the order in which the players will support the issue under consideration. A power index assigns to each player in an issue game a nonnegative number, where these numbers sum up to one. We consider a class of power indices, characterized by weight vectors on the set of issues. A power index in this class assigns to each player the weighted sum of the issues for which that player is pivotal. A player is pivotal for an issue if that player is a pivotal player in the coalition consisting of all players preceding that player in the linear order associated with that issue. We present several axiomatic characterizations of this class of power indices. The first characterization is based on two axioms: one says how power depends on the issues under consideration (Issue Dependence), and the other one concerns the consequences, for power, of splitting players into several new players (no advantageous splitting). The second characterization uses a stronger version of Issue Dependence, and an axiom about symmetric players (Invariance with respect to Symmetric Players). The third characterization is based on a variation on the transfer property for values of simple games (Equal Power Change), besides Invariance with respect to Symmetric Players and another version of Issue Dependence. Finally, we discuss how an issue profile may arise from preferences of players about issues.
About Symmetry in Partially Hinged Composite Plates
Authors: Berchio Elvise , Falocchi Alessio 
Published: September 2020

AbstractWe consider a partially hinged composite plate problem and we investigate qualitative properties, e.g. symmetry and monotonicity, of the eigenfunction corresponding to the density minimizing the first eigenvalue. The analysis is performed by showing related properties of the Green function of the operator and by applying polarization with respect to a fixed plane. As a by-product of the study, we obtain a Hopf type boundary lemma for the operator having its own theoretical interest. The statements are complemented by numerical results.
Management of differentiated thyroid cancer through nuclear medicine facilities during Covid-19 emergency: the telemedicine challenge
Authors: Klain Michele , Nappi Carmela , Maurea Simone , De Risi Marina , Volpe Fabio , Caiazzo Elisa , Piscopo Leandra , Manganelli Mariarosaria , Schlumberger Martin , Cuocolo Alberto 
Published: September 2020

Abstract
Purpose
To investigate whether a telemedicine service (TMS) carried out during the Covid-19 pandemic impacted on management of patients with differentiated thyroid cancer (DTC).

Methods
We retrospectively reviewed the number and the findings of outpatient visits in DTC subjects referred between March 11, 2020, and May 31, 2020, during the Covid-19 pandemic at the Radiometabolic Unit of the University of Naples Federico II. Office visits scheduled in March and May 2020 were converted in teleconsultation reaching all patients planned for an in-ward access to advise them to use the TMS for all clinical necessity. The number and the findings of DTC patients evaluated by in-ward access in the corresponding period of 2019 were also assessed for direct comparison.

Results
The number of outpatient visits performed by TMS during the pandemic (n = 445) and by in-ward access in the corresponding period of 2019 (n = 525) was comparable with only 15% of outpatient evaluations missed.

Conclusions
Our findings demonstrate the utility of telemedicine tools to avoid the potential negative impact of interruption or postponement of diagnostic and/or therapeutic procedures. Therefore, investments in medical network system development, including the implementation of telehealth approaches, should be encouraged at national and international levels.
Flow around a scoured bridge pier: a stereoscopic PIV analysis
Authors: Jenssen Ulrich , Manhart Michael 
Published: September 2020

Abstract
We performed stereoscopic particle image velocimetry of the turbulent flow inside a scour hole around a cylinder in a sandy bed. At two planes, symmetry plane and $$45^\circ$$

45
∘

with respect to the approach flow, the flow and its turbulence structure were investigated. We used two Reynolds numbers (20, 000 and 39, 000) based on the cylinder diameter and the depth-averaged velocity in the symmetry plane. The flow is characterized by a strong down-flow in front of the cylinder, a large horseshoe vortex inside the scour, and an upstream directed wall jet underneath. The values of vorticity in the horseshoe vortex and of the velocity in the wall jet are larger than in a comparable configuration on a flat bed. Enhanced levels of turbulent kinetic energy are found around the horseshoe vortex and in the shear layer detaching from the rim. The orientation of the main axis of the velocity fluctuations changes when the flow enters the scour hole: from about wall-parallel in the detaching shear layer to vertical at the horseshoe vortex. The production of turbulent kinetic energy shows a maximum upstream of the horseshoe vortex centre with considerable production in the shear layer and in the wall jet underneath the horseshoe vortex. Furthermore, strong wall-parallel velocity fluctuations are visible in this region, and bimodal velocity distributions are found, but not anywhere else. The time-averaged wall-shear stresses are largest under the horseshoe vortex and most likely larger than in a corresponding flat-bed configuration.

Graphic abstract