bluuebunny/crossref_metadata_2025_split huggingface dataset:
When three’s a crowd: how relational structure and social history shape organizational codes in triads
Authors: Koçak Özgecan , Warglien Massimo 
Published: August 2020

AbstractWhen members of an organization share communication codes, coordination across subunits is easier. But if groups interact separately, they will each develop a specialized code. This paper asks: Can organizations shape how people interact in order to create shared communication codes? What kinds of design interventions in communication structures and systems are useful? In laboratory experiments on triads composed of dyads that solve distributed coordination problems, we examine the effect of three factors: transparency of communication (versus privacy), role differentiation, and the subjects’ social history. We find that these factors impact the harmonization of dyadic codes into triadic codes, shaping the likelihood that groups develop group-level codes, converge on a single group-level code, and compress the group-level code into a single word. Groups with transparent communication develop more effective codes, while acyclic triads composed of strangers are more likely to use multiple dyadic codes, which are less efficient than group-level codes. Groups of strangers put into acyclic configurations appear to have more difficulty establishing “ground rules”—that is, the “behavioral common ground” necessary to navigate acyclic structures. These coordination problems are transient—groups of different structures end up with the same average communication performance if given sufficient time. However, lasting differences in the code that is generated remain.
CRP (C Reactive Protein) level after total knee replacement in Indian population--- does it follow Anglo-Saxon trend?
Authors: Londhe Sanjay Bhalchandra , Shah Ravi Vinod , Doshi Amit Pankaj , Londhe Shubhankar Sanjay , Subhedar Kavita 
Published: August 2020

Abstract
Background
This study was to determine how C-reactive protein (CRP) responds after total knee replacement (TKR), including both unilateral and simultaneous bilateral TKR in Indian population and if it follows Anglo-Saxon trend. Published literature from North America and Europe shows CRP value peaks on the 2nd post-operative day and drops to normal by 6–8 weeks. We started the study with null hypothesis.

Material and methods
This is a prospective study, with 50 patients (all females, 25 received unilateral operations and 25 bilateral ones) included. CRP levels were measured, on the 2nd day, 8, 12 and 16 weeks after operation.

Results
In both groups, CRP level rose the 2nd post-operative day. The rise in CRP level was significantly higher in the simultaneous bilateral TKR group than in the unilateral TKR group. In unilateral cases, CRP on the 2nd postoperative day ranged from 65 to 110 mg/l with average level of 80 mg/ml. In bilateral TKR cases, CRP level on the 2nd postoperative day was between 110 and 180 mg/l with a mean of 140 mg/ml. The CRP level returned to normal in about 40% of unilateral TKR patients 8 weeks after operation, while in 92% (23 out of 25) of bilateral simultaneous TKR patients it stayed at a high level 8 weeks post-op and did not come back to normal. At 12 weeks CRP decreased to normal in all 100% of unilateral TKR patients and 32% of bilateral TKR patients. At 16 weeks, CRP was normal in all bilateral TKR patients.

Conclusion
60% of our unilateral TKR patients and 92% of our simultaneous bilateral TKR patients did not achieve a normal CRP 8 weeks after operation. These findings are significant as CRP is commonly used as a very sensitive indicator of postoperative joint infection. Hence we conclude that in the Indian TKR patients the CRP values take longer time to return to normal than in their Anglo-Saxon counterparts. Published results regarding the normal levels of CRP in unilateral TKR should not be extrapolated to simultaneous bilateral TKR patients.
Barriers to the Delivery of Timely, Guideline-Adherent Adjuvant Therapy Among Patients With Head and Neck Cancer
Authors: Graboyes Evan M. , Halbert Chanita Hughes , Li Hong , Warren Graham W. , Alberg Anthony J. , Calhoun Elizabeth A. , Nussenbaum Brian , Marsh Courtney H. , McCay Jessica , Day Terry A. , Kaczmar John M. , Sharma Anand K. , Neskey David M. , Sterba Katherine R. 
Published: August 2020

PURPOSE: Delays initiating guideline-adherent postoperative radiation therapy (PORT) in head and neck squamous cell carcinoma (HNSCC) are common, contribute to excess mortality, and are a modifiable target for improving survival. However, the barriers that prevent the delivery of timely, guideline-adherent PORT remain unknown. This study aims to identify the multilevel barriers to timely, guideline-adherent PORT and organize them into a conceptual model. MATERIALS AND METHODS: Semi-structured interviews with key informants were conducted with a purposive sample of patients with HNSCC and oncology providers across diverse practice settings until thematic saturation (n = 45). Thematic analysis was performed to identify the themes that explain barriers to timely PORT and to develop a conceptual model. RESULTS: In all, 27 patients with HNSCC undergoing surgery and PORT were included, of whom 41% were African American, and 37% had surgery and PORT at different facilities. Eighteen clinicians representing a diverse mix of provider types from 7 oncology practices participated in key informant interviews. Five key themes representing barriers to timely PORT were identified across 5 health care delivery levels: (1) inadequate education about timely PORT, (2) postsurgical sequelae that interrupt the tight treatment timeline (both intrapersonal level), (3) insufficient coordination and communication during care transitions (interpersonal and health care team levels), (4) fragmentation of care across health care organizations (organizational level), and (5) travel burden for socioeconomically disadvantaged patients (community level). CONCLUSION: This study provides a novel description of the multilevel barriers that contribute to delayed PORT. Interventions targeting these multilevel barriers could improve the delivery of timely, guideline-adherent PORT and decrease mortality for patients with HNSCC.
Impact of a Cancer Gene Variant Reclassification Program Over a 20-Year Period
Authors: Esterling Lisa , Wijayatunge Ranjula , Brown Krystal , Morris Brian , Hughes Elisha , Pruss Dmitry , Manley Susan , Bowles Karla R. , Ross Theodora S. 
Published: August 2020

PURPOSE Hereditary cancer genetic testing can inform personalized medical management for individuals at increased cancer risk. However, many variants in cancer predisposition genes are individually rare, and traditional tools may be insufficient to evaluate pathogenicity. This analysis presents data on variant classification and reclassification over a 20-year period. PATIENTS AND METHODS This is a retrospective analysis of > 1.9 million individuals who received hereditary cancer genetic testing from a single clinical laboratory (March 1997 to December 2017). Variant classification included review of evidence from traditional tools (eg, population frequency databases, literature) and laboratory-developed tools (eg, novel statistical methods, in-house RNA analysis) by a multidisciplinary expert committee. Variants may have been reclassified more than once and with more than one line of evidence. RESULTS In this time period, 62,842 unique variants were observed across 25 cancer predisposition genes, and 2,976 variants were reclassified. Overall, 82.1% of reclassification events were downgrades (eg, variant of uncertain significance [VUS] to benign), and 17.9% were upgrades (eg, VUS to pathogenic). Among reclassified variants, 82.8% were initially classified as VUS, and 47.5% were identified in ≤ 20 individuals (allele frequency ≤ 0.001%). Laboratory-developed tools were used in 72.3% of variant reclassification events, which affected > 600,000 individuals. More than 1.3 million patients were identified as carrying a variant that was reclassified within this 20-year time period. CONCLUSION The variant classification program used by the laboratory evaluated here enabled the reclassification of variants that were individually rare. Laboratory-developed tools were a key component of this program and were used in the majority of reclassifications. This demonstrates the importance of using robust and novel tools to reclassify rare variants to appropriately inform personalized medical management.
Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause
Authors: Greendale Gail A , Witt-Enderby Paula , Karlamangla Arun S , Munmun Fahima , Crawford Sybil , Huang MeiHua , Santoro Nanette 
Published: August 2020

Abstract

Context
Melatonin may play a role in the regulation of the human menstrual cycle and may decline with menopause and/or aging.

Objective
The objective of this work is to investigate the relations between melatonin and the menstrual cycle, menopause, and aging.

Methods
This was a cross-sectional and longitudinal analysis of 20 participants from the Study of Women’s Health Across the Nation (SWAN) Daily Hormone Study (DHS). The outcome measure was first-morning urine assay of 6-sulfatoxymelatonin (aMT6s), a gauge of melatonin. For each participant, aMT6s was measured daily during one premenopausal cycle with evidence of luteal activity (ELA) and one postmenopausal collection with no evidence of luteal activity (NELA).

Results
In addition to the organized patterns of hormone metabolites (estrone conjugates [E1c], and pregnanediol glucuronide [PdG]) and gonadotropins that characterized ovulatory menstrual cycles, there was a late luteal rise in aMT6s. In NELA collections, there was no periodicity of E1c, PdG, gonadotropins, or aMT6s. The strongest predictors of aMT6s levels were PdG values 11 to 12 days prior to aMT6s (β = 1.46, P = .001 and β = 1.44, P = .001, respectively). E1c and gonadotropins were not statistically significantly associated with aMT6s. Mean aMT6s in premenopause was 53.5 ng/mL, greater than the mean of 37.4 ng/mL in postmenopausal samples from the same women (P = .0002).

Conclusions
This study confirms a late luteal melatonin rise, likely signaled by progesterone, which may influence menstrual cycle pacemaker control. Melatonin declined from premenopause to postmenopause. A high correlation between menopause transition stage and age precludes distinction between the influences of ovarian and chronological aging.
Functionally distinct roles for T and Tbx6 during mouse development
Authors: Wehn Amy K. , Farkas Deborah R. , Sedlock Carly E. , Subedi Dibya , Chapman Deborah L. 
Published: August 2020

ABSTRACT
The mouse T-box transcription factors T and Tbx6 are co-expressed in the primitive streak and have unique domains of expression; T is expressed in the notochord, while Tbx6 is expressed in the presomitic mesoderm. T-box factors are related through a shared DNA binding domain, the T-domain, and can therefore bind to similar DNA sequences at least in vitro. We investigated the functional similarities and differences of T and Tbx6 DNA binding and transcriptional activity in vitro and their interaction genetically in vivo. We show that at one target, Dll1, the T-domains of T and Tbx6 have different affinities for the binding sites present in the mesoderm enhancer. We further show using in vitro assays that T and Tbx6 differentially affect transcription with Tbx6 activating expression tenfold higher than T, that T and Tbx6 can compete at target gene enhancers, and that this competition requires a functional DNA binding domain. Next, we addressed whether T and Tbx6 can compete in vivo. First, we generated embryos that express Tbx6 at greater than wild-type levels embryos and show that these embryos have short tails, resembling the T heterozygous phenotype. Next, using the dominant-negative TWis allele, we show that Tbx6+/− TWis/+ embryos share similarities with embryos homozygous for the Tbx6 hypomorphic allele rib-vertebrae, specifically fusions of several ribs and malformation of some vertebrae. Finally, we tested whether Tbx6 can functionally replace T using a knockin approach, which resulted in severe T null-like phenotypes in chimeric embryos generated with ES cells heterozygous for a Tbx6 knockin at the T locus. Altogether, our results of differences in affinity for DNA binding sites and transcriptional activity for T and Tbx6 provide a potential mechanism for the failure of Tbx6 to functionally replace T and possible competition phenotypes in vivo.
A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
Authors: Echols Josh , Siddiqui Amna , Dai Yanying , Havasi Viktoria , Sun Richard , Kaczmarczyk Aneta , Keeling Kim M. 
Published: August 2020

ABSTRACT
Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of genetic diseases. NMD also limits the efficiency of suppressing translation termination at PTCs, an emerging therapeutic approach to treat genetic diseases caused by in-frame PTCs (nonsense mutations). Inhibiting NMD may help rescue partial levels of protein expression. However, it is unclear whether long-term, global NMD attenuation is safe. We hypothesize that a degree of NMD inhibition can be safely tolerated after completion of prenatal development. To test this hypothesis, we generated a novel transgenic mouse that expresses an inducible, dominant-negative form of human UPF1 (dnUPF1) to inhibit NMD in mouse tissues by different degrees, allowing us to examine the effects of global NMD inhibition in vivo. A thorough characterization of these mice indicated that expressing dnUPF1 at levels that promote relatively moderate to strong NMD inhibition in most tissues for a 1-month period produced modest immunological and bone alterations. In contrast, 1 month of dnUPF1 expression to promote more modest NMD inhibition in most tissues did not produce any discernable defects, indicating that moderate global NMD attenuation is generally well tolerated in non-neurological somatic tissues. Importantly, a modest level of NMD inhibition that produced no overt abnormalities was able to significantly enhance in vivo PTC suppression. These results suggest that safe levels of NMD attenuation are likely achievable, and this can help rescue protein deficiencies resulting from PTCs.
Characterization of buccal cell DNA after exposure to azo compounds: a cross-sectional study
Authors: Handajani Juni , Tabtila Urfa , Rully Auliawati Nadia , Rohman Abdul 
Published: August 2020

Background: Azo compounds, containing naphthol and diazonium salts, are synthetic dyes widely used in the batik industry. Azo compounds are considered toxic when they are exposed to human tissue. The purpose of this study was to analyze buccal cell DNA exposed to azo compounds in batik workers. Methods: A cross-sectional study involving 20 male subjects divided into two groups (n=10 group), namely azo-exposed and non-exposed (control group). Inclusion criteria were batik workers of the colouring division who have been exposed to azo for at least 5 years. Buccal cells were taken using cytobrush then DNA were isolated from buccal cell. DNA isolation was done by buccal DNA kit, while the purity and concentration of the DNA was determined using spectrophotometer and electrophoresis. Results: The azo-exposed group revealed higher purity DNA than those in the control group. The purity of the DNA in the azo-exposed group and control group was 0.61±0.93 and 0.21±0.09, respectively, while the concentration of DNA was of 59.02 and 19.35 ng/UL, respectively. The ratio at 260/280 nm was 1.84-1.94 (azo-exposed) and 1.85-1.92 (control). Principal component analysis using the first principle component (PC1) and second principle component (PC2) could successfully classify subjects in the control and azo-exposed groups. Conclusion: Characteristics of DNA could be used as an indication of exposure to azo compounds in workers of batik industries.
Läänemeresoome mAs-isikunimed
Authors: Saar Evar 
Published: August 2020

Artikkel käsitleb läänemeresoome ajaloolisi isikunimesid, mille lõpus on nimeformant (sufiks) -mas või -mäs (ühine tähistus -mAs) Antakse ülevaade, milliseid mAs-nimesid ja ka muid mVs-nimesid on allikatest leitud. Püstitatakse hüpotees, et kirjapiltidega -mes ja -meß esindatud isikunimed ei sisalda järelosisena sõna mees, nagu mitmed uurijad varem on väitnud. Analüüsitakse mVs-lõpuliste isikunimede võimalikku hääldust keskalamsaksa ortograafia ja tekstinäidete taustal. Käsitletakse mAs-sufiksi võimalikku päritolu ja jälgi läänemeresoome keeltes. Vaatluse all on ka mAs-isikunimede tüübi mõju järgnenud kristlikele laennimedele ja seosed tänapäeva eesnimedega. Eesti kohanimede vanades dokumendikujudes esinevat lõppu -mas või -mes on samuti vaadeldud. Selle tüübiga seoses pakutakse välja selged isikunimejuhtumid Ihamaru ja Viimsi, analüüsitakse jätkuvalt lahtise etümoloogiaga nime Teilma ja juhitakse tähelepanu mõnedele teistelegi tänapäeval ma-lõpulistele nimedele.
Abstract. Evar Saar: Finnic personal names with the suffix -mAs. This article addresses Finnic pre-Christian personal names which ended with the suffix -mas or -mäs (joint marking -mAs). An overview of which mAs-names and also mVs-names have been found in the sources is provided. A hypothesis is formulated that personal names represented by spellings -mes and -meß do not contain the word mees ‘man’ as the second component, as many researchers have claimed. Such spellings have been found in the names of Estonians and Livonians from medieval Livonia. The possible pronunciation of personal names ending in mVs are analysed in the context of Middle Low German orthography and text samples. Written mes-endings in personal names link, on the one hand, with the phenomenon that in preserving the Finnic vowel harmony, the letter -e was the main presentation of the Finnic sound -ä. This enables such interpretations as, for example, Melemes (*Meelemäs). At the same time, vowel harmony was disappearing in medieval North Estonian language which means that -ä in successive syllables was still replaced with a. Another and more important tendency characterising spellings with Middle Low German background is the perception of most vowels in successive syllables in a reduced form and writing them by e. Finnic suffix mAs has been interpreted on the example of Ihama and Ihamas by Päivi Rintala. Rintala considers the short suffix mA primary, which has especially functioned as individualising the object. mAs personal names are alive in modern Estonian in a Christian first name Toomas with an accidentally similar end structure and in a new first name Urmas created by Julius Mägiste. First name Armas ( Estonian meaning ‘lovely’) that is widespread in Finland and the historical Ihamas recommended by Mägiste have not become popular in Estonia.
Efficient emission of InGaN-based light-emitting diodes: toward orange and red
Authors: Zhang Shengnan , Zhang Jianli , Gao Jiangdong , Wang Xiaolan , Zheng Changda , Zhang Meng , Wu Xiaoming , Xu Longquan , Ding Jie , Quan Zhijue , Jiang Fengyi 
Published: August 2020

Indium gallium nitride (InGaN)-based light-emitting diodes (LEDs) are considered a promising candidate for red-green-blue (RGB) micro displays. Currently, the blue and green LEDs are efficient, while the red ones are inefficient for such applications. This paper reports our work of creating efficient InGaN-based orange and red LEDs on silicon(111) substrates at low current density. Based on the structure of InGaN yellow LEDs, by simply reducing the growth temperature of all the yellow quantum wells (QWs), we obtained 599 nm orange LEDs with peak wall-plug efficiency (WPE) of 18.1% at

2

A
/

cm
2

. An optimized QW structure was proposed that changed two of the nine yellow QWs to orange ones. Compared with the sample containing nine orange QWs, the sample with two orange QWs and seven yellow QWs showed similar emission spectra but a much higher peak WPE up to 24.0% at

0.8

A
/

cm
2

with a wavelength of 608 nm. The improvement of peak WPE can be attributed to the improved QW quality and the reduced active recombination volume. Subsequently, a series of efficient InGaN-based orange and red LEDs was demonstrated. With further development, the InGaN-based red LEDs are believed to be attainable and can be used in micro LED displays.
Achievement of full enteral feeding using volume advancement in infants with birth weight 1,000 to <2,000 grams
Authors: Hendrayanti Teti , Ramadanti Afifa , Indrayady Indrayady , Indra Raden Muhammad 
Published: August 2020

Background Early enteral feeding is one of the efforts to improve gastrointestinal adaptability in preterm infants. Volume advancement (VA) enteral feeding has been associated with less time to reach full feeding, which can improve outcomes.
Objective To evaluate the duration of VA needed to achieve full enteral feeding (FEF) in low birth weight (LBW) and very low birth weight (VLBW) infants and related factors.
Methods This prospective study was done in infants with birth weight 1,000 to <2,000 grams in the Neonatal Ward and NICU of Dr. Moh. Hoesin General Hospital, Palembang, South Sumatera. All infants underwent VA feeding. The time needed to achieve FEF (150 ml/kg/day) was recorded. Several clinical factors were analyzed for possible associations with the success rate of achieving FEF within 10 days of feeding.
Results Thirty-five infants were included in this study with a mean gestational age of 31.83 (SD 2.67) weeks. Their median body weight at the start of protocol was 1,400 (range 1,000 – 1,950) grams and 80% had hyaline membrane disease. Median time to achieve FEF was 11 (range 8–21) days, with 48.6% subjects achieving FEF in ≤10 days. Gestational age <32 weeks (OR 5.404, 95%CI 0.963 to 30.341), birth weight <1,500 grams (OR 5.248, 95%CI 0.983 to 28.003), and male (OR 4.751, 95%CI 0.854 to 26.437) gender were associated with the failure of achieving FEF within 10 days of feeding, however, no factors remained statistically significant after multivariate analysis.
Conclusion Full enteral feedings in infants with birth weight 1,000 to <2,000 grams with VA feeding are achieved within a median of 11 days. Gestational age, birth weight, and gender are not associated with time needed to achieve FEF.
Implementation of Dengue Recurrent Shock Prediction Score in pediatric dengue shock syndrome
Authors: Liwan Armand Setiady , Gustawan I Wayan , Gunawijaya Eka , Soetjiningsih Soetjiningsih , Ariawati Ketut , Hartawan I Nyoman Budi 
Published: August 2020

Background Global morbidities due to dengue viral infection increase yearly. The pediatric mortality rate from dengue shock syndrome (DSS) remains high. Early identification of the risk of recurrent shock may serve to increase awareness and reduce mortality. The Dengue Recurrent Shock Prediction Score (DRSPS) is a tool to predict recurrent shock in children with DSS, but the optimal cut-off point in our population is still unknown.
Objective To assess the validity of the DRSPS by determining the optimal cut-off point that can be used in Indonesia
Methods This cross-sectional prospective study was done at Sanglah Hospital, Denpasar, Bali, from January 2019. Risk of reccurent shock were classify based on DRSPS in all DSS patient, and they were observed whether they will experienced recurrent shock or not.
Results Of 56 children with DSS, 27 subjects had recurrent shock and 29 subjects did not. The optimal DRSPS cut-off point was -189.9 for predicting recurrent shock, with 87.4% area under the curve (AUC), 81.5% sensitivity and 82.8% specificity.
Conclusion The optimal cut-off point of DRSPS was -189.9 and it has good validity. The results of this study are expected not only to be used as the basis for further study, but to increase physician awareness in treating DSS patients.