bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Profiling of FSH and Estradiol in Ovarian Granulosa Cell Tumors
Authors: Haltia Ulla-Maija , Pihlajoki Marjut , Andersson Noora , Mäkinen Lotta , Tapper Johanna , Cervera Alejandra , Horlings Hugo M , Turpeinen Ursula , Anttonen Mikko , Bützow Ralf , Unkila-Kallio Leila , Carpén Olli , Wilson David B , Heikinheimo Markku , Färkkilä Anniina 
Published: March 2020

Abstract
Adult-type granulosa cell tumors (AGCTs) are sex-cord derived neoplasms with a propensity for late relapse. Hormonal modulators have been used empirically in the treatment of recurrent AGCT, albeit with limited success. To provide a more rigorous foundation for hormonal therapy in AGCT, we used a multimodal approach to characterize the expressions of key hormone biomarkers in 175 tumor specimens and 51 serum samples using RNA sequencing, immunohistochemistry, RNA in situ hybridization, quantitative PCR, and circulating biomarker analysis, and correlated these results with clinical data. We show that FSH receptor and estrogen receptor beta (ERβ) are highly expressed in the majority of AGCTs, whereas the expressions of estrogen receptor alpha (ERα) and G-protein coupled estrogen receptor 1 are less prominent. ERβ protein expression is further increased in recurrent tumors. Aromatase expression levels show high variability between tumors. None of the markers examined served as prognostic biomarkers for progression-free or overall survival. In functional experiments, we assessed the effects of FSH, estradiol (E2), and the aromatase inhibitor letrozole on AGCT cell viability using 2 in vitro models: KGN cells and primary cultures of AGCT cells. FSH increased cell viability in a subset of primary AGCT cells, whereas E2 had no effect on cell viability at physiological concentrations. Letrozole suppressed E2 production in AGCTs; however, it did not impact cell viability. We did not find preclinical evidence to support the clinical use of aromatase inhibitors in AGCT treatment, and thus randomized, prospective clinical studies are needed to clarify the role of hormonal treatments in AGCTs.
Flavonols regulate root hair development by modulating accumulation of reactive oxygen species in the root epidermis
Authors: Gayomba Sheena R. , Muday Gloria K. 
Published: March 2020

ABSTRACT
Reactive oxygen species (ROS) are signaling molecules produced by tissue-specific respiratory burst oxidase homolog (RBOH) enzymes to drive development. In Arabidopsis thaliana, ROS produced by RBOHC was previously reported to drive root hair elongation. We identified a specific role for one ROS, H2O2, in driving root hair initiation and demonstrated that localized synthesis of flavonol antioxidants control the level of H2O2 and root hair formation. Root hairs form from trichoblast cells that express RBOHC and have elevated H2O2 compared with adjacent atrichoblast cells that do not form root hairs. The flavonol-deficient tt4 mutant has elevated ROS in trichoblasts and elevated frequency of root hair formation compared with the wild type. The increases in ROS and root hairs in tt4 are reversed by genetic or chemical complementation. Auxin-induced root hair initiation and ROS accumulation were reduced in an rbohc mutant and increased in tt4, consistent with flavonols modulating ROS and auxin transport. These results support a model in which localized synthesis of RBOHC and flavonol antioxidants establish patterns of ROS accumulation that drive root hair formation.
Scaling up single-cell mechanics to multicellular tissues – the role of the intermediate filament–desmosome network
Authors: Broussard Joshua A. , Jaiganesh Avinash , Zarkoob Hoda , Conway Daniel E. , Dunn Alexander R. , Espinosa Horacio D. , Janmey Paul A. , Green Kathleen J. 
Published: March 2020

ABSTRACT
Cells and tissues sense, respond to and translate mechanical forces into biochemical signals through mechanotransduction, which governs individual cell responses that drive gene expression, metabolic pathways and cell motility, and determines how cells work together in tissues. Mechanotransduction often depends on cytoskeletal networks and their attachment sites that physically couple cells to each other and to the extracellular matrix. One way that cells associate with each other is through Ca2+-dependent adhesion molecules called cadherins, which mediate cell–cell interactions through adherens junctions, thereby anchoring and organizing the cortical actin cytoskeleton. This actin-based network confers dynamic properties to cell sheets and developing organisms. However, these contractile networks do not work alone but in concert with other cytoarchitectural elements, including a diverse network of intermediate filaments. This Review takes a close look at the intermediate filament network and its associated intercellular junctions, desmosomes. We provide evidence that this system not only ensures tissue integrity, but also cooperates with other networks to create more complex tissues with emerging properties in sensing and responding to increasingly stressful environments. We will also draw attention to how defects in intermediate filament and desmosome networks result in both chronic and acquired diseases.
Children and adolescents on anti-retroviral therapy in Bulawayo, Zimbabwe: How many are virally suppressed by month six?
Authors: Moyo Silungile , Ncube Ronald Thulani , Shewade Hemant Deepak , Ngwenya Solwayo , Ndebele Wedu , Takarinda Kudakwashe Collin , Dzangare Janet , Goverwa-Sibanda Tafadzwa Priscilla , Apollo Tsitsi 
Published: March 2020

Background: Zimbabwe is one of the countries in sub-Saharan Africa disproportionately affected by human immunodeficiency virus. In the “treat all” era, we assessed the gaps in routine viral load (VL) monitoring at six months for children (0-9 years) and adolescents (10-19 years) newly initiated on anti-retroviral therapy (ART) from January 2017 to September 2018 at a large tertiary hospital in Bulawayo. Methods: In this cohort study using secondary data, we considered first VL done within six to nine months of starting therapy as ‘undergoing VL test at six months’. We classified repeat VL≥1000 copies/ml despite enhanced adherence counselling as virally unsuppressed. Results: Of 295 patients initiated on ART, 196 (66%) were children and 99 (34%) adolescents. A total 244 (83%) underwent VL test at six months, with 161 (54%) virally suppressed, 52 (18%) unsuppressed and 82 (28%) with unknown status (due to losses in the cascade). Switch to second line was seen in 35% (18/52). When compared to children, adolescents were less likely to undergo a VL test at six months (73% versus 88%, p=0.002) and more likely to have an unknown VL status (40% versus 22%, p=0.001). Conclusion: At six months of ART, viral suppression was low and losses in the cascade high.
Modern Features of the Transformation of the World and Russian Labor Markets
Authors: Svistunov Vasiliy , Konovalova Valeriya , Lobachyev Vitaliy 
Published: March 2020

The article is devoted to the assessment of the impact of modern digital technologies on the world and Russian labor market. The relevance of the chosen problem is explained by the fact that the achieved level of digital development of society has a signifi cant impact on the size of labor markets, the qualifi cation composition of workers, the demand for certain professions. The article presents the results of the analysis of the impact of digital technology on the growth of Russia’s GDP, the contribution of individual factors of growth in value added of diff erent sectors of the economy, including the sectoral dimension, the dynamics
of digital technologies across regions of the country. The article presents the results of studies characterizing new trends in the labor market, formed as a response to the increasingly active penetration of the digital economy in the socioeconomic sphere of society.
Dependence of changes in hematological and integrative parameters in patients with chronic viral hepatitis C on the received antiviral therapy
Authors: Lishnevska A. H. , Chemych M. D. 
Published: March 2020

A total of 287 patients were treated with various antiviral therapy options: group I – basic (pathogenetic and symptomatic) therapy, group II – pegylated interferon in combination with ribavirin, group III – pegylated interferon with ribavirin and sofosbuvir, group IV – direct-acting antivirals. Patients with chronic viral hepatitis C (CVHC) before the start of treatment showed a decrease in platelet counts, segmented neutrophils and an increase in level of lymphocytes, bilirubin content, alanine aminotransferase activity, aspartate, transferrinase (practice), with a comparison group (practically virus-free patients) <0.05. After 4 weeks of receiving interferon-containing therapy, a further decrease was observed: leukocyte count, erythrocyte count, platelet count; ALT, AST and gamma-glutamyltranspeptidase (GGTP) activity; increased erythrocyte sedimentation rate (ESR), bilirubin content, and bilirubin activity p< 0.05. Patients who received direct-acting antivirals (DAAs) had a decrease in: erythrocyte count, total bilirubin content, ALT activity, AST, GGTP; increase in sed rate and the AST/ALT ratio, p <0.05. After 12 weeks of treatment, patients treated with pegylated interferon were diagnosed with a decrease in platelet count, erythrocyte count, and leukocyte count (with the exception of patients with dual therapy that experienced the slight increase of the leukocytes) with hemoglobin content, p <0.05. Also, in the group II subjects compared with week 4 decreased: the content of bilirubin and creatinine, the activity of ALT, AST, GGTP, while the De Ritis ratio increased (p <0.05). Patients in group III had lower GGTP activity than at 4 weeks and lower ALT and AST values compared with the onset of antiviral therapy (p <0.05). Patients receiving DAAs experienced a decrease in hemoglobin content; no changes in biochemical parameters at this stage compared with the previous one were established.The investigated integrative indicators suggest changes in the immune system of patients, in particular the prevalence of cellular immunity over the humoral link and the predominance of the autoimmune component. Patients with dual and triple PVT regimens had more pronounced changes compared to patients receiving DAAs.
A Re-Solving Heuristic with Uniformly Bounded Loss for Network Revenue Management
Authors: Bumpensanti Pornpawee , Wang He 
Published: March 2020

We consider a canonical quantity-based network revenue management problem where a firm accepts or rejects incoming customer requests irrevocably in order to maximize expected revenue given limited resources. Because of the curse of dimensionality, the exact solution to this problem by dynamic programming is intractable when the number of resources is large. We study a family of re-solving heuristics that periodically re-optimize an approximation to the original problem known as the deterministic linear program (DLP), where random customer arrivals are replaced by their expectations. We find that, in general, frequently re-solving the DLP produces the same order of revenue loss as one would get without re-solving, which scales as the square root of the time horizon length and resource capacities. By re-solving the DLP at a few selected points in time and applying thresholds to the customer acceptance probabilities, we design a new re-solving heuristic with revenue loss that is uniformly bounded by a constant that is independent of the time horizon and resource capacities. This paper was accepted by Kalyan Talluri, revenue management and market analytics.
Penetration capability of near infrared Laguerre–Gaussian beams through highly scattering media
Authors: di Bartolo Francesco , Malik Muhammad N. , Scaffardi Mirco , Bogoni Antonella , Celi Simona , Ghelfi Paolo , Malacarne Antonio 
Published: March 2020

The higher capability of optical vortex beams of penetrating turbid media (e.g., biological fluids) with respect to the conventional Gaussian beams is, for the first time to our knowledge, demonstrated in the 1.3 µm wavelength range which is conventionally used for optical coherence tomography procedures in endoscopic intravascular scenarios. The effect has been demonstrated by performing transmittance measurements through suspensions of polystyrene microspheres in water with various particulate concentrations and, in reflection, by using samples of human blood with different thicknesses. The reduced backscattering/increased transmittance into such highly scattering media of Laguerre–Gaussian beams with respect to Gaussian ones, in the near infrared wavelength region, could be potentially exploited in clinical applications, leading to novel biomedical diagnoses and/or procedures.
Controllable formation of laser-induced periodic surface structures on ZnO film by temporally shaped femtosecond laser scanning
Authors: Wang Shaojun , Jiang Lan , Han Weina , Liu Wei , Hu Jie , Wang Suocheng , Lu Yongfeng 
Published: March 2020

We achieved the controllable formation of laser-induced periodic surface structures (LIPSSs) on ZnO films deposited on fused silica induced by modulated temporally shaped femtosecond (fs) laser pulses (800 nm, 50 fs, 1 kHz) through the laser scanning technique. Two-dimensional (2D) high spatial frequency LIPSSs (HSFLs) with a period from 100 to 200 nm could be flexibly modulated based on the preprocessed nanostructures with appropriate fs laser irradiation conditions (fluence, scanning speed, and pulse delay). The finite-difference time-domain (FDTD) method combined with the Drude model was employed to calculate the redistributions of electric fields, which suggested the origin of HSFL formation.
Big data no suporte à estratégia de produção: ilustração de aplicação em serviço público
Authors: Campos Fernando Celso , Alves Filho Alceu Gomes 
Published: March 2020

A partir de toda tecnologia relacionada com internet foram surgindo dados disponibilizados nos mais diversos formatos e lugares de armazenamento – o Big Data. Ele suporta as visões gerenciais e estratégicas de um modo novo e dinâmico, eficaz e relevante, combinando fatores e ferramentas. A estratégia de produção é um padrão global de decisões que recebe diretrizes de uma estratégia de negócios, e é altamente dependente de dados e informações. Ela ampliou-se para um padrão geral de decisões determinando competências a longo prazo e contribuições para a estratégia global (requisitos de mercado e recursos de operações). O objetivo desse artigo é apresentar um framework que dê suporte à estratégia de produção utilizando aspectos de Big Data. O método de pesquisa foi realizado em três etapas: i) pesquisa bibliográfica; ii) elaboração de um framework teórico-conceitual; e iii) ilustração de aplicação do framework proposto. A contribuição principal foi a sistematização de uma proposta utilizando-se referencial teórico consolidado de estratégia de produção e referencial mais recente acerca de Big Data. A aplicação em um serviço público gerou uma expectativa de continuidade e de busca por meios tecnológicos para se verificar em quanto tempo se solucionariam os problemas e qual a economia advinda dessa implantação.
Perempuan dan IMS : Perilaku Menjaga Personal Hygiene Organ Reproduksi pada Pekerja Seks Langsung di Indonesia
Authors: Rokhmah Dewi , Nurwidyansyah Shinta Dwi , Rif'ah Erwin Nur 
Published: March 2020

Background: The localization of prostitution in Jember District has been closed permanently since 2007. It causes the hidden prostitution business that has been increasing in the street or as indirect sex work. This condition makes the limited access to provide information, condoms and STDs screening among female sex workers (FSWs). Besides using condom, washing reproductive organs are often conducted to prevent STDs. This study aims to explore the behavior of FSWs in washing and lubricating reproductive organs. Method: This is a qualitative research which involved 12 FSWs in three areas of ex-localization in South Jember, 5 pims and health staffs. Data were collected through indepth-interviews and observation of work areas. Thematic content analysis was employed to identify themes and patterns of data. Results: The behavior of genital hygiene among FSWs to keep healthy was relatively categorized not good. Beside low consistent in condom use, most of them wash their vagina using traditional herbs or soap. They also often drink traditional herbs to prevent STDs. Lack of knowledge and support from the pimps and health staffs to use condom during sex made them vulnerable from STDs. Changing panties routinely and avoid anal sex were practiced among FSWs to have safe sex.
KIM EOK’S TRANSLATION AND HAN YONG-UN’S THE LOVER’S SILENCE – THE INTERIORITY IN THE 1920s’ LITERATURE
Authors: Yang Soon-Mo 
Published: March 2020

The article tries to examine and define the inner self of literature in the 1920s, now considered the birth of modern Korean literature. The interiority of 1920’s literature is widely accepted as the transition period between the birth (the 1910s, the Enlightenment) and maturation (1930s, Modernism), and as a reflection of the tragic situation after 1919. However, in the light of the symptom that determines the structure of desire, the inner self of 1920’s literature could be identified as a “person who denies loss”, a pervasive attitude. And it also could provide a critical reading along with some directivity, which is meaningful to concepts such as self-relation and the other relations that construct the individual. This paper examines this perspective of inner self within 1920’s literature of Kim Eok and Han Yong-un, so as to set an intrinsic standard that would enable scholars to evaluate the literary value of the 1920’s. Above all, through the Symptomatic Identification approach, this study will conduct archeological and genealogical research that could be helpful to today’s discourse.
Gastric Neuroendocrine Neoplasias: Literature Review
Authors: Mikhaleva Liudmila M. , Vasyukova Olesya A. , Birukov Andrey E. , Guschin Mikhail Yu. , Midiber Konstantin Yu. , Akopyan Emma P. , Khovanskaya Tatyana N. 
Published: March 2020

A brief retrospective journey into the history of neouroendocrine neoplasias serves to remind the histology and distribution of neuroendocrine cells in the gastric mucosa, followed by chronological review of NEN discovery and theory development up to the present moment. The morphological classification of gastric NET consisting of 4 possible types is highlighted: the correct interpretation of the pathological findings, taking into account not only the histological features of the tumor itself, but also of the adjacent mucosa, allows to suggest the appropriate managment, which fundamentally affects patient survival.
The review provides other current classifications of the gastric neuroendocrine neoplasia depending on its location, embryogenesis, functional activity, histological grade (with a focus on the Ki-67 labeling index counting, and ways to improve the interobserver reliability in routine practice). Moreover, the differences in the gastric NET and NEC TNM classification are emphasized. The drawbacks of all classifications are discussed and the possibilities for their further development are considered. An important part of the review is the description of a possible immunohistochemical markers, since immunohistochemistry is widely used to confirm the diagnosis. In addition, INSM1 (insulinomaassociatedprotein 1), the new immunohistochemical and molecular marker for NEN is discussed: according to the literature, it contributes to more accurate assessment of the tumor malignant potential and the metastatic risk.
Furthermore, modern methods of endoscopic and PET/CT imaging (68-gallium DOTATATE PET/CT, molecular imaging using SSTR (somatostatin receptor) PET/CT or GLP-1R (Glucagon-like peptide-1 receptor) SPECT (single photon emission computed tomography)/CT), which allows the clinician to suspect a NEN even before morphological analysis of the resected specimen and adequately select the extent of surgical intervention are shown.
In conclusion, we would like to reiterate the importance of further research on the gastric NET subtype pathogenesis and their clinical behavior, also of the correlation of the endoscopic, morphological, and immunohistochemical picture with the patient prognosis to improve managment tactics.
Does full enteral feed from day one of life influence weight gain in hemodynamically stable VLBW babies weighing between 1000-1500 grams as against standard feeding? a randomized controlled trial
Authors: Shanmugam Ramya S. , Bharathi Mangala , Jayaraman Kumutha 
Published: March 2020

Background: Preterm neonates post-natal growth should be similar to the intrauterine growth of the fetus of the same gestational age. This study aims to evaluate the effects of full enteral feed (60 ml/kg/day of human milk on day one, 20ml/kg/day during feeding advancement) started from day one of life (intervention) in enhancing the regain of birth weight compared to that of standard feed (both human milk feeds and intravenous fluid) in a group.Methods: Babies were started on enteral feeds with human milk at the rate of 60ml/kg/day from day one and progressed by increments of 20 ml/kg/day up to maximum enteral feed of 180 ml/kg/day. The primary outcomes like Number of days taken to regain the birth weight, Duration of hospital stay, Incidence of Necrotising Enterocolitis (NEC), Incidence of sepsis, need for intravenous fluid therapy was assessed and statically analysed.Results: Full enteral feeding group infants had lesser days of intravenous fluids. Full enteral feeding group regained birth weight at a mean age of 17.37±4.9 days and in the standard feeding group, birth weight was regained at a mean age of 19.8±4.3. Full enteral feeding group regained birth weight at a mean age of 13.12±2.17 days and in standard feeding group at a mean age of 15.38±3.57and this was statistically significant (p - 0.009). Full enteral feeding group babies had lesser number of days of intravenous fluids compared to babies in standard feeding group. It was statistically significant (p - 0.003).Conclusions: There is lack of awareness regarding dog bite and its management among the rural population.
PSYCHOLOGICAL EMPOWERMENT AND ITS RELATIONSHIP WITH DECISION-MAKING STYLES AMONG AL-AZHAR TEACHERS
Authors: Mohamed Abdellatif Mohamed Sayed 
Published: March 2020

Purpose: The research aimed to identify the relationship between psychological empowerment and decision-making Styles among Al-Azhar teachers. The research also aimed to identify the differences in teachers' levels on the (psychological empowerment and decision-making styles) scale according to the variable (gender).
Methodology: The research sample consisted of (556) male and female teachers in Al-Azhar. The research tools included a psychological empowerment scale and decision-making styles scale. The researcher used descriptive methods. To process the results and validate the hypotheses, the researcher used the correlation coefficients and t-test.
Main Findings: The results show that there is a positive relationship between psychological empowerment and decision-making styles. There is a negative correlation between the dimensions of psychological empowerment and decision-making styles. The results indicated a statistically significant difference in psychological empowerment due to gender in favor of males. Lastly, there is no statistically significant difference due to gender in the (intuitive) style.
Implication: Psychological empowerment should be utilized to raise the decision-making styles of university students.
Novelty: This is a first attempt to explore the psychological empowerment of the decision-making styles of university students in Egypt which may be further explored to enrich the students’ understanding.