bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ibrutinib dose modifications in the management of CLL
Authors: Hardy-Abeloos Camille , Pinotti Rachel , Gabrilove Janice 
Published: June 2020

Abstract
Background
Ibrutinib is a Bruton tyrosine kinase inhibitor approved for the treatment of chronic lymphocytic leukemia (CLL) in 2014. Ibrutinib is often used to treat patients who are younger than the patients originally included in theclinical trials have additional unfavorable prognostic factors and suffer from additional comorbidities excluded from the original phase III trials. Our objective was to examine current clinical practices and their impact in this expanded population of CLL patients who often require adjustments in the standard prescribed dose and schedule of therapy.

Materials and methods
An extensive review of the medical literature was conducted to establish the consensus on ibrutinib dose modifications in patients with CLL. Twenty-nine studies were reviewed including fourteen clinical trials and fifteen “real-world practice” studies.

Results
The average discontinuation rate was similar between clinical trials and “real-world practice” studies though the reasons for discontinuation differed. CLL progression was a more common reason for discontinuation in clinical trial studies while toxicity was a more common reason for discontinuation in “real-world practice” studies. Some studies have suggested worse outcomes in patients requiring dose reductions in ibrutinib while others have shown no change in treatment efficacy in patients requiring dose reductions due to concomitant CYP medications or increased immunosuppression post-transplant.

Conclusion
The impact of ibrutinib dose modifications on clinical outcome remains unclear. Patients on concomitant CYP3A inhibitors should be prescribed a lower dose than the standard 420 mg daily, in order to maintain comparable pharmacologic properties. Further research is required to establish definitive clinical practice guidelines.
The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes
Authors: Haidari Fatemeh , Zakerkish Mehrnoosh , Borazjani Fatemeh , Ahmadi Angali Kambiz , Amoochi Foroushani Golnaz 
Published: June 2020

Abstract
Background
The objective of this study was to investigate the effects of Anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in patients with type 2 diabetes.

Materials and methods
In this study, 42 patients with type 2 diabetes were randomly allocated to intervention and control groups and received either 3 g/day dill powder or placebo (3 capsules/day, 1 g each). Fasting blood sugar, insulin, homeostatic model assessment of insulin resistance, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, malondialdehyde and gastrointestinal symptoms were measured in all of the subjects at baseline and postintervention.

Results
The dill powder supplementation significantly decreased the mean serum levels of insulin, homeostatic model assessment of insulin resistance, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde in the intervention group in comparison with the baseline measurements (P < 0.05). Furthermore, the mean serum levels of high-density lipoprotein and total antioxidant capacity were significantly increased in the intervention group in comparison with the baseline measurement (P < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes in insulin, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde were significantly lower in the intervention group than in the control group (P < 0.05). In addition, the mean changes in high-density lipoprotein were significantly higher in the intervention group than in the control group (P < 0.05).

Conclusion
Dill powder supplementation can be effective in controlling the glycemic, lipid, stress oxidative and gastrointestinal symptoms in patients with type 2 diabetes.

Trial registration
Iran Clinical Trials Registry: IRCT20120704010181N12. Registered on 12 May 2018.
Immunosuppressive treatment in diffuse cutaneous systemic sclerosis is associated with an improved composite response index (CRISS)
Authors: Zheng Boyang , Hudson Marie , Wang Mianbo , Baron Murray ,   for the Canadian Scleroderma Research Group, Pope Janet E. , Baron Murray , Hudson Marie , Gyger Geneviève , Larché Maggie J. , Khalidi Nader A. , Masetto Ariel , Sutton Evelyn , Robinson David , Rodriguez-Reyna Tatiana S. , Maltez Nancy , Smith Doug , Thorne Carter , Ikic Alena , Fortin Paul R. , Fritzler Marvin J. 
Published: June 2020

Abstract
Background
Outcomes of therapeutic studies in diffuse cutaneous systemic sclerosis (dcSSc) have mainly been measured for specific organs, particularly the skin and lungs. A new composite response index in dcSSc (CRISS) has been developed for clinical trials. The goal of this study was to determine whether, in an observational dcSSc cohort, immunosuppression was associated with global disease improvement measured with the CRISS.

Methods
We conducted a retrospective cohort study in a multi-centered SSc registry comparing 47 patients newly exposed to immunosuppression for ≥ 1 year to 254 unexposed patients. Inverse probability of treatment weighting (IPTW) was performed to create comparable exposed and unexposed groups by balancing for age, sex, disease duration, modified Rodnan skin score (mRSS), forced vital capacity, patient and physician global assessments, and Health Assessment Questionnaire score. A CRISS score ≥ 0.6 at 1 year was defined as improvement.

Results
Exposed patients had shorter disease duration (5.5 versus 11.7 years, p < 0.01), more interstitial lung disease (67.4% versus 40.3%, p < 0.01), and worse physician global severity scores (4.2 versus 2.5 points, p < 0.01) compared to unexposed patients. Improvement in CRISS scores was more common in exposed patients after IPTW (odds ratio 1.85, 95% confidence interval 1.11, 3.09). Of the individual CRISS variables, only mean patient global assessment scores were significantly better among exposed than unexposed patients (− 0.4 versus 0 points, p = 0.03) while other variables including mRSS were similar.

Conclusion
Using a composite response measure, immunosuppression was associated with better outcomes at 1 year in a dcSSc cohort. These results provide real-world data that align with clinical trials to support our current use of immunosuppression.
Physical-Layer-Security Box: a concept for time-frequency channel-reciprocity key generation
Authors: Zoli Marco , Barreto André Noll , Köpsell Stefan , Sen Padmanava , Fettweis Gerhard 
Published: June 2020

AbstractThe motivation for this study about Physical Layer Security comes from bridging the gap between the vast theory and a feasible implementation. We propose a Physical-Layer-Security Box as a system-level Box is a system-level solution, named PLS-Box, to solve the key exchange between two wireless communicating parties. The PLS-Box performs a novel key generation method named time-frequency filter-bank. The entropy of the radio channel is harvested via a filter-bank processing, and then turned into a reciprocal security key, at both ends. In this concept work, we also focus on several PLS open issues, such as radio-frequency imperfections and accessibility to the baseband communication modem. The goal is to show a wide applicability of our PLS-Box to actual wireless systems, paving the way for an evolution of existing schemes.
Some identities of type 2 q-Bernoulli polynomials
Authors: Yun Sang Jo , Park Jin-Woo 
Published: June 2020

AbstractRecently, symmetric properties of some special polynomials arising from p-adic q-integrals on ${\mathbb{Z}}_{p}$Zp have been investigated extensively by many researchers.In this paper, we find some symmetric identities for type 2 q-Bernoulli polynomials under the symmetry group $S_{n}$Sn of degree n by using the bosonic p-adic q-integral on ${\mathbb{Z}}_{p}$Zp.
New analytical method based on dynamic response of planar mechanical elastic systems
Authors: Scutaru Maria Luminiţa , Vlase Sorin , Marin Marin , Modrea Arina 
Published: June 2020

AbstractAn important stage in an analysis of a multibody system (MBS) with elastic elements by the finite element method is the assembly of the equations of motion for the whole system. This assembly, which seems like an empirical process as it is applied and described, is in fact the result of applying variational formulations to the whole considered system, putting together all the finite elements used in modeling and introducing constraints between the elements, which are, in general, nonholonomic. In the paper, we apply the method of Maggi’s equations to realize the assembly of the equations of motion for a planar mechanical systems using finite two-dimensional elements. This presents some advantages in the case of mechanical systems with nonholonomic liaisons.
A new approach to approximate solutions for a class of nonlinear multi-term fractional differential equations with integral boundary conditions
Authors: O KyuNam , Jong KumSong , Pak SunAe , Choi HuiChol 
Published: June 2020

AbstractIn this paper, we discuss the existence and uniqueness of solutions for a class of integral boundary value problems of nonlinear multi-term fractional differential equations and propose a new method to obtain their approximate solutions. The existence results are established by the Banach fixed point theorem, and approximate solutions are determined by the Daftardar-Gejji and Jafari iterative method (DJIM) and the Adomian decomposition method (ADM). Finally, we present some examples to illustrate the existence result and the effectiveness of applied approximate techniques.
An application of upscaled optimal foraging theory using hidden Markov modelling: year-round behavioural variation in a large arctic herbivore
Authors: Beumer Larissa T. , Pohle Jennifer , Schmidt Niels M. , Chimienti Marianna , Desforges Jean-Pierre , Hansen Lars H. , Langrock Roland , Pedersen Stine Højlund , Stelvig Mikkel , van Beest Floris M. 
Published: June 2020

Abstract
Background
In highly seasonal environments, animals face critical decisions regarding time allocation, diet optimisation, and habitat use. In the Arctic, the short summers are crucial for replenishing body reserves, while low food availability and increased energetic demands characterise the long winters (9–10 months). Under such extreme seasonal variability, even small deviations from optimal time allocation can markedly impact individuals’ condition, reproductive success and survival. We investigated which environmental conditions influenced daily, seasonal, and interannual variation in time allocation in high-arctic muskoxen (Ovibos moschatus) and evaluated whether results support qualitative predictions derived from upscaled optimal foraging theory.

Methods
Using hidden Markov models (HMMs), we inferred behavioural states (foraging, resting, relocating) from hourly positions of GPS-collared females tracked in northeast Greenland (28 muskox-years). To relate behavioural variation to environmental conditions, we considered a wide range of spatially and/or temporally explicit covariates in the HMMs.

Results
While we found little interannual variation, daily and seasonal time allocation varied markedly. Scheduling of daily activities was distinct throughout the year except for the period of continuous daylight. During summer, muskoxen spent about 69% of time foraging and 19% resting, without environmental constraints on foraging activity. During winter, time spent foraging decreased to 45%, whereas about 43% of time was spent resting, mediated by longer resting bouts than during summer.

Conclusions
Our results clearly indicate that female muskoxen follow an energy intake maximisation strategy during the arctic summer. During winter, our results were not easily reconcilable with just one dominant foraging strategy. The overall reduction in activity likely reflects higher time requirements for rumination in response to the reduction of forage quality (supporting an energy intake maximisation strategy). However, deep snow and low temperatures were apparent constraints to winter foraging, hence also suggesting attempts to conserve energy (net energy maximisation strategy). Our approach provides new insights into the year-round behavioural strategies of the largest Arctic herbivore and outlines a practical example of how to approximate qualitative predictions of upscaled optimal foraging theory using multi-year GPS tracking data.
Dynamic analysis of the extended space charge layer using chronopotentiometric measurements
Authors: Cho Inhee , Lee Hyomin , Kim Sung Jae 
Published: June 2020

AbstractIn this paper, we experimentally verified the length (LESC) and the concentration (cESC) of the extended space charge (ESC) layer in front of the electrical double layer (EDL) using the chronopotentiometric measurement and the equivalent circuit model analysis. From the experimentation, the coupled-response of the EDL and the ESC layer was discriminated from the contribution of electro-osmotic flow (EOF). In addition, we derived the potential differences across the ESC (VESC) layer using the circuit model of the ICP layer under rigorous consideration of ESC and EDL. As a result, we obtained that VESC was linearly proportional to the square of the applied current (iapplied). Hence, LESC and cESC were quantitatively provided, where LESC is linear to the iapplied and cESC is constant regardless of iapplied. Thus, this experimentation could not only clarify an essential ICP theory but also guide in ESC-based applications.
Solute tracer test quantification of the effects of hot water injection into hydraulically stimulated crystalline rock
Authors: Kittilä Anniina , Jalali Mohammadreza , Saar Martin O. , Kong Xiang-Zhao 
Published: June 2020

AbstractWhen water is injected into a fracture-dominated reservoir that is cooler or hotter than the injected water, the reservoir permeability is expected to be altered by the injection-induced thermo-mechanical effects, resulting in the redistribution of fluid flow in the reservoir. These effects are important to be taken into account when evaluating the performance and lifetime particularly of Enhanced Geothermal Systems (EGS). In this paper, we compare the results from two dye tracer tests, conducted before (at ambient temperature of $$13\,^{\circ } \text {C}$$13∘C) and during the injection of $$45\,^{\circ } \text {C}$$45∘C hot water into a fractured crystalline rock at the Grimsel Test Site in Switzerland. Conducting a moment analysis on the recovered tracer residence time distribution (RTD) curves, we observe, after hot water injection, a significant decrease in the total tracer recovery. This recovery decrease strongly suggests that fluid flow was redistributed in the studied rock volume and that the majority of the injected water was lost to the far-field. Furthermore, using temperature measurements, obtained from the same locations as the tracer RTD curves, we conceptualize an approach to estimate the fracture surface area contributing to the heat exchange between the host rock and the circulating fluid. Our moment analysis and simplified estimation of fracture surface area provide insights into the hydraulic properties of the hydraulically active fracture system and the changes in fluid flow. Such insights are important to assess the heat exchange performance of a geothermal formation during fluid circulation and to estimate the lifetime of the geothermal formation, particularly in EGS.
Factors affecting aseptic loosening in primary total knee replacements: an in vitro study
Authors: Lionberger David , Wattenbarger Laura , Conlon Christopher , Walker Timothy J. 
Published: June 2020

Abstract
Background
Implant surface integrity and cement bonding are assumed to be sufficient in primary total knee replacements to stabilize implants for extended wear without concerns over delamination and loosening. Yet there exists a significant rate of aseptic loosening where failure at implant cement interface occurs. The aim of this study is to look at specific aspects leading to aseptic loosening of the total knee replacement, where cement adhesion to the implant results in the lowest pull off strength.

Methods
Virgin ceramic coated and uncoated chrome cobalt tibial trays were used in a pull off study using differing viscosities of cement at varied time intervals to compare which combination is strongest compared to which is least resistant to pull off testing.

Results
Low viscosity cement had a 44% (5.9 kg verses 3.3 kg, p < 0.001) higher pull-off strength compared to high viscosity cement. Coated implants had a 30% (3.9 kg verses 5.5 kg, p = 0.037) lower pull-off strength compared to non-coated. Testing measures were limited to cement utilization less than 5 minutes due to the poor adhesion of the dowels beyond this time. Finally, there was a significant difference in adhesion properties between brand names when utilizing low viscosity cement on the non-coated trays (10.34 kg for Simplex verses 4.87 for Palacos, p = 0.021).

Conclusion
There are differences in adhesion properties between cement vendors, prompting significant concerns over the use of coated implants with particular cement types. Use of low viscosity cement on non-coated surfaces in the early liquid phase of cement curing was found to produce the best chance for adequate adhesion. This study demonstrates that there is variation in the adhesive properties of implants utilized in total knee replacements, and that the orthopedic community should consider not only the implant, cement, and curing time individually, but the overall integrity conferred from the combination of all of these variables.
Achieving corporate sustainability performance: The influence of corporate ethical value, and leader-member exchange on employee behaviors and organizational performance
Authors: Lee Stacy H. 
Published: June 2020

AbstractThis study investigated how corporate sustainability performance can be attained through the interface of corporate ethical values and leader-member exchange, and how employees’ positive and negative behaviors can influence these relationships. A total of 310 data sets were collected and used to test our hypotheses. To assess the factorability of the variables, exploratory factor analysis was conducted, and confirmatory factor analysis was conducted to test the fit and validity of the measurement model. Then, the structural model proceeded to test the hypotheses. The results of this study found that employee behaviors can highly influence corporate sustainability performance. Depending on contextual or/and relational factors, employee behaviors can either encourage more organizational citizenship behavior or alleviate counterproductive work behavior. These findings demonstrate that it is critical not only to create an ethical working environment but also to develop quality relationships with direct managers.
Linking Tensegrity to Sports Team Collective Behaviors: Towards the Group-Tensegrity Hypothesis
Authors: Caldeira Paulo , Fonseca Sérgio Teixeira , Paulo Ana , Infante Jorge , Araújo Duarte 
Published: June 2020

AbstractCollective behaviors in sports teams emerge from the coordination between players formed from their perception of shared affordances. Recent studies based on the theoretical framework of ecological dynamics reported new analytical tools to capture collective behavior variables that describe team synergies. Here, we introduce a novel hypothesis based on the principles of tensegrity to describe collective behavior. Tensegrity principles operate in the human body at different size scales, from molecular to organism levels, in structures connected physically (biotensegrity). Thus, we propose that a group of individuals connected by information can exhibit synergies based on the same principles (group-tensegrity), and we provide an empirical example based on the dynamics of a volleyball team sub-phase of defense.
A study of glycemic variability in patients with type 2 diabetes mellitus with obstructive sleep apnea syndrome using a continuous glucose monitoring system
Authors: Khaire Suhas S. , Gada Jugal V. , Utpat Ketaki V. , Shah Nikita , Varthakavi Premlata K. , Bhagwat Nikhil M. 
Published: June 2020

Abstract
Background
Obstructive sleep apnea syndrome (OSAS) in association with Type 2 Diabetes Mellitus (DM) may result in increased glycemic variability affecting the glycemic control and hence increasing the risk of complications associated with diabetes. We decided to assess the Glycemic Variability (GV) in patients with type 2 diabetes with OSAS and in controls. We also correlated the respiratory disturbance indices with glycemic variability indices.

Methods
After fulfilling the inclusion and exclusion criteria patients from the Endocrinology and Pulmonology clinics underwent modified Sleep Apnea Clinical Score (SACS) followed by polysomnography (PSG). Patients were then divided into 4 groups: Group A (DM with OSAS, n = 20), Group B (DM without OSAS, n = 20), Group C (Non DM with OSAS, n = 10) and Group D (Non DM without OSAS, n = 10). Patients in these groups were subjected to continuous glucose monitoring using the Medtronic iPro2 and repeat PSG. Parameters of GV: i.e. mean glucose, SD (standard Deviation), CV (Coefficient of Variation), Night SD, Night CV, MAGE and NMAGE were calculated using the Easy GV software. GV parameters and the respiratory indices were correlated statistically. Quantitative data was expressed as mean, standard deviation and median. The comparison of GV indices between different groups was performed by one-way analysis of variance (ANOVA) or Kruskal Wallis (for data that failed normality). Correlation analysis of AHI with GV parameters was done by Pearson correlation.

Results
All the four groups were adequately matched for age, sex, Body Mass Index (BMI), waist circumference (WC) and blood pressure (BP). We found that the GV parameters Night CV, MAGE and NMAGE were significantly higher in Group A as compared to Group B (p values < 0.05). Similarly Night CV, MAGE and NMAGE were also significantly higher in Group C as compared to Group D (p value < 0.05). Apnea-hypopnea index (AHI) correlated positively with Glucose SD, MAGE and NMAGE in both diabetes (Group A plus Group B) and non- diabetes groups (Group C plus Group D).

Conclusions
OSAS has a significant impact on the glycemic variability irrespective of glycemic status. AHI has moderate positive correlation with the glycemic variability.