bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of cortisol concentrations in plasma and saliva in dairy cattle following ACTH stimulation
Authors: Riek Alexander , Schrader Lars , Zerbe Frank , Petow Stefanie 
Published: November 2019

AbstractThe experiments described in this research communication compared cortisol concentrations in plasma and saliva samples collected from dairy cattle before and after an adrenocorticotropic hormone (ACTH) application. For that purpose, blood and saliva samples were collected from five dairy cows at determined time intervals before (490 min and down to 0 min) and after (10 min and up to 500 min) an ACTH application. Mean baseline cortisol concentrations were greater in plasma compared to saliva. The relative increases and decreases in plasma and salivary cortisol concentrations following ACTH were similar. After ACTH, we observed an increase in cortisol concentrations in plasma after 10 min and in saliva after 20 min. The time of peak concentrations after ACTH were reached at 70 and 80 min for plasma and saliva, respectively. After peak concentrations, values steadily declined and returned to baseline values at 169 ± 15 min in plasma and 170 ± 14 min in saliva. Ratios between salivary and plasma cortisol concentrations were on average 0.09 and did not change substantially during the ACTH challenge. There was a strong positive relationship between salivary and plasma cortisol concentrations. These results indicate that salivary cortisol concentrations can be a good indicator of ACTH-induced plasma cortisol concentrations in dairy cattle.
Radiation and electron thermal conduction damping of acoustic perturbations in igniting deuterium–tritium gas
Authors: Galloway Conner D. , Hunter Robert O. , Valys Alexander V. , McCall Gene H. 
Published: November 2019

We derive a dispersion relation for the damping of acoustic waves in equi-molar deuterium–tritium (DT) gas due to radiation coupling and electron thermal conduction and discuss its significance for inertial confinement fusion (ICF) targets with high-Z shells surrounding a central DT fuel region. As the shell implodes around DT fuel in such a target, shocks and waves are transmitted through the DT gas. If the shell is perturbed due to drive non-uniformity or manufacturing imperfection, these shocks and waves may be perturbed as well, and can potentially re-perturb the shell. This can complicate calculation of shell stability and implosion asymmetry and in general make the target less robust against implosion non-uniformity. Damping of perturbations in DT gas can alleviate these complications. Also, damping of low-order modes, which is primarily due to radiation coupling, can drive the DT gas to an isobaric and isothermal ‘equilibrium’ configuration during ignition. We find that for the range of common ignition temperatures in targets with high-Z shells,

$2.5\lesssim T_{ig}\lesssim 3.5$

keV, damping of low-order modes is significant for areal densities (

$\unicode[STIX]{x1D70C}r$

) in the broad range of

$0.6\lesssim \unicode[STIX]{x1D70C}r\lesssim 1.8~\text{g}~\text{cm}^{-2}$

. This suggests it is advantageous to design these targets to achieve areal densities at ignition within this range. Furthermore, we derive a simple constraint between areal density and temperature,

$\unicode[STIX]{x1D70C}r=0.34T_{o}$

where

$T_{o}$

is in keV, such that DT gas undergoing equilibrium ignition is optimally robust against non-uniformity.
Performance Improvement of PD-Based Bilateral Teleoperator with Time Delay by Introducing High-Pass Filter
Authors: Imaida Takashi , Senda Kei 
Published: November 2019

SUMMARYStability is a major problem with bilateral teleoperator when there is a transmission time delay. By adding adequate damping gain into position servo, a stable bilateral control can be achieved under the existence of time delay. However, large damping gain is required to stabilize the system and the performance is degraded. In this paper, the performance improvement by introducing a high-pass filter into a proportional derivative-based teleoperator with time delay has been studied. We proposed new control law and derived the stability condition. We demonstrated the performance improvement using a hybrid matrix, 1-degree of freedom (DOF), 2-DOF simulations, and 2-DOF peg-in-hole experiments.
Cell Membrane Nanostructure is Altered by Heat-Induced Antigen Retrieval: A Possible Consequence for Immunocytochemical Detection of Membranous Antigens
Authors: Cizkova Katerina , Malohlava Jakub , Tauber Zdenek 
Published: November 2019

AbstractHeat-induced antigen retrieval (HIAR) treatment improves the antigen immunodetection in formalin-fixed, paraffin-embedded tissue samples and it can also improve the detection of intracellular antigens in alcohol-fixed cytological samples, although it could deleteriously impact immunodetection, particularly that of membranous antigens. We examined the differences in cell surface topography on MCF7 cells fixed in methanol/acetone (M/A) or 4% paraformaldehyde (4% PFA), as well as the changes caused by HIAR treatment at three different temperatures (60, 90, and 120°C), using atomic force microscopy. Furthermore, the consequences for immunostaining of five membranous antigens [epidermal growth factor receptor (EGFR), E-cadherin, CD9, CD24, and CD44] were examined. Our results illustrate that while there was no one single optimal immunostaining condition for the tested antibodies, the surface topography could be an important factor in successful staining. Generally, the best conditions for successful immunostaining were M/A fixation with no HIAR treatment, whereas in 4% PFA-fixed cells, HIAR treatment at 120°C was optimal. These conditions showed similarity in cell surface skewness. A correlation factor between successful immunocytochemical staining and the skewness parameter was 0.8000. Our results indicate that the presence of valleys, depressions, scratches, and pits on the cell surface is unfavorable for the successful immunodetection of cell surface antigens.
The Weitin Fault, Papua New Guinea, Ruptured Twice by Mw 8.0 and Mw 7.7 Earthquakes in 2000 and 2019
Authors: Chen Kejie , Milliner Chris , Avouac Jean‐Philippe 
Published: November 2019

AbstractWe determine the fault geometry and kinematic slip models of the 2019 Mw 7.7 and 2000 Mw 8.0 earthquakes in Papua New Guinea using measurements from optical image correlation and teleseismic waveforms. The 2000 earthquake ruptured an extensive fault system over a distance of ~150 km including the entire 60‐km long onshore segment of the Weitin fault and its offshore continuation southeast of New Ireland. The northern portion of the onshore Weitin fault segment ruptured again in 2019. Most of the moment was released by a compact, shallow, high stress‐drop slip patch on the northwestern continuation of the Weitin fault in the Saint George Channel, which was brought closer to failure by the 2000 earthquake. The two ruptures overlap over about 20 km but in fact mostly complement each other. Large dynamic stresses may have driven the partial rerupture of the Weitin fault during the 2019 event.
The Intermittency of Wind‐Driven Sand Transport
Authors: Comola F. , Kok J. F. , Chamecki M. , Martin R. L. 
Published: November 2019

AbstractWind‐blown sand is the main driver of dune development and dust emission from soils and is thus of fundamental importance for geomorphology, ecology, climate, and air quality. Even though sand transport is driven by nonstationary turbulent winds, and is thus inherently intermittent, current parameterizations in atmospheric models assume stationary wind and continuous transport. We draw on extensive field measurements to show that neglecting saltation intermittency causes biases in the timing and intensity of predicted fluxes. We present a simple parameterization that accounts for saltation intermittency and produces substantially improved agreement against measurements. We investigate the implications of accounting for transport intermittency in atmospheric models by analyzing 35 years of hourly wind speed data from climate simulations. We show that accounting for intermittency leads to significantly different predictions of sand mass fluxes throughout the year, with potential implications for timing and intensity of dust emission.
Constraining the Oceanic Lithosphere Seismogenic Zone Using Teleseismic Relocations of the 2012 Wharton Basin Great Earthquake Sequence
Authors: Kwong Kevin B. , DeShon Heather R. , Saul Joachim , Thurber Clifford H. 
Published: November 2019

AbstractThe great 2012 Mw 8.6 strike‐slip earthquake beneath the Wharton Basin generated a complex aftershock sequence that maps onto a system of conjugate faults. Analysis of high‐precision aftershock locations with improved depth constraint is used here to characterize the seismogenic limits of the oceanic lithosphere. The study presents teleseismic double‐difference earthquake relocation results for 695 events in and around the 2012 Wharton Basin intraplate earthquake sequence. We highlight seven major clusters of seismicity and show that the 2012 earthquake sequence ruptured in the oceanic crust and upper mantle. The refined aftershock locations projected onto available mainshock finite‐fault models show that aftershocks occur outside the largest coseismic slip region and tend to cluster in low slip areas, a pattern commonly seen for large continental and megathrust sequences. For events with depth phases, the relocated focal depths generally correspond to predicted depths from pP‐P time observations. Reported pP‐P observations for intraplate events correspond to depths ranging from ~5 to 35–40 km, such that the deepest events occur within the expected limit of brittle seismic failure at 600 °C, here defined by a half‐space cooling model of the region. The 74 low magnitude events in our catalog that locate below the 600 °C isotherm do not have consistent depth phase observations and cannot be interpreted as strong evidence of rupture into the ductile regime. The refined double‐difference catalog supports that, along with deep coseismic rupture, moderate‐sized earthquakes ruptured across the full extent of the elastic oceanic lithosphere in the Wharton Basin.
Multi‐Grid Nesting Ability to Represent Convections Across the Gray Zone
Authors: Liang Xin‐Zhong , Li Qi , Mei Haixia , Zeng Mingjian 
Published: November 2019

AbstractThis study investigated the multi‐grid nesting ability of a limited area model to effectively represent convections across the gray zone, the resolution around 1–10 km where both cumulus parameterization and explicit convection are problematic. It evaluated the sensitivity of Meiyu rainfall forecasts in Jiangsu, China to model configurations of grid nesting and convection treatment. These configurations consisted of grid spacings from 30, 15, 9, 5, 3 to 1 km, single or double or triple nested grids, and the traditional Kain‐Fritsch (KF) or scale‐aware Grell‐Freitas cumulus parameterization or the explicit convection in the outer domain [O]. In single nesting [O], coarse grids (>3–5 km) required parameterization to represent organized cumuli, while explicitly resolving convections in finer grids were necessary to improve forecasts. In double nesting [O] using cumulus parameterization at 30–9 km with the inner domain [I] using explicit convection at 1 km, the nesting ratio could be as large as 30 without significantly impacting [I] forecasts. This suggests a pragmatic approach to avoid the challenge in representing convections across the gray zone. Using Grell‐Freitas may improve mean [O] rainfall distributions, but this was not true for [I] forecasts due to counter errors in space and time, which were larger than using KF and at coarser grids. Triple nesting with a middle 3‐ or 5‐km grid was unnecessary and could even degrade [I] forecasts. Nesting [O] using KF to parameterize cumuli at 15 km with [I] explicitly resolving convections at 1 km achieved the best overall rainfall forecast in Jiangsu.
Neotectonics of Southeast Jamaica Derived From Marine Seismic Surveys and Gravity Cores
Authors: Wright Vanshan , Hornbach Matthew , Brown Lyndon , McHugh Cecilia , Mitchell Simon 
Published: November 2019

AbstractTectonics in Southeast Jamaica is poorly understood, but the region may contain currently unknown faults that could generate large‐magnitude earthquakes. This study constrains tectonics in Southeast Jamaica by collecting and analyzing seismic and shallow sediment core data in and around Kingston Harbor. Seismic results reveal a previously unrecognized strike‐slip fault system that accommodates strain via a complex mix of compression and extension. The faults appear to be a blind extension of one major fault (i.e., The Bull Bay Strike‐Slip Fault) within the Enriquillo‐Plantain Garden Fault Zone. This fault system may represent significant hazards to Kingston Jamaica because the fault is active, located less than 5 km from the city, and a complete rupture of the fault could generate aMw5.8–6.9 earthquake. Our analyses highlight the need for continued paleoseismic studies, both onshore and offshore Jamaica.
Overlapping spatial clusters of sugar-sweetened beverage intake and body mass index in Geneva state, Switzerland
Authors: Joost Stéphane , De Ridder David , Marques-Vidal Pedro , Bacchilega Beatrice , Theler Jean-Marc , Gaspoz Jean-Michel , Guessous Idris 
Published: November 2019

Abstract
Background
Obesity and obesity-related diseases represent a major public health concern. Recently, studies have substantiated the role of sugar-sweetened beverages (SSBs) consumption in the development of these diseases. The fine identification of populations and areas in need for public health intervention remains challenging. This study investigates the existence of spatial clustering of SSB intake frequency (SSB-IF) and body mass index (BMI), and their potential spatial overlap in a population of adults of the state of Geneva using a fine-scale geospatial approach.

Methods
We used data on self-reported SSB-IF and measured BMI from residents aged between 20 and 74 years of the state of Geneva (Switzerland) that participated in the Bus Santé cross-sectional population-based study (n = 15,423). Getis-Ord Gi spatial indices were used to identify spatial clusters of SSB-IF and BMI in unadjusted models and models adjusted for individual covariates (education level, gender, age, nationality, and neighborhood-level median income).

Results
We identified a significant spatial clustering of BMI and SSB-IF. 13.2% (n = 2034) of the participants were within clusters of higher SSB-IF and 10.7% (n = 1651) were within clusters of lower SSB-IF. We identified overlapping clusters of SSB-IF and BMI in specific areas where 11.1% (n = 1719) of the participants resided. After adjustment, the identified clusters persisted and were only slightly attenuated indicating that additional neighborhood-level determinants influence the spatial distribution of SSB-IF and BMI.

Conclusions
Our fine-scale spatial approach allowed to identify specific populations and areas presenting higher SSB-IF and highlighted the existence of an overlap between populations and areas of higher SSB-IF associated with higher BMI. These findings could guide policymakers to develop locally tailored interventions such as targeted prevention campaigns and pave the way for precision public health delivery.
Ultralong UV/mechano-excited room temperature phosphorescence from purely organic cluster excitons
Authors: Zhang Xuepeng , Du Lili , Zhao Weijun , Zhao Zheng , Xiong Yu , He Xuewen , Gao Peng Fei , Alam Parvej , Wang Can , Li Zhen , Leng Jing , Liu Junxue , Zhou Chuanyao , Lam Jacky W. Y. , Phillips David Lee , Zhang Guoqing , Tang Ben Zhong 
Published: November 2019

AbstractPurely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over 600 ms and overall quantum yield of over 20% is realized. Meanwhile, the URTP can also be achieved by mechanical excitation when the host is mechanoluminescent. Femtosecond transient absorption studies reveal that intersystem crossing of the host is accelerated substantially in the presence of a trace amount of 1,8-naphthalic anhydride. Accordingly, we propose that a cluster exciton spanning the host and guest forms as a transient state before the guest acts as an energy trap for the RTP state. The cluster exciton model proposed here is expected to help expand the varieties of purely organic URTP materials based on an advanced understanding of guest/host combinations.
Room temperature and low-field resonant enhancement of spin Seebeck effect in partially compensated magnets
Authors: Ramos R. , Hioki T. , Hashimoto Y. , Kikkawa T. , Frey P. , Kreil A. J. E. , Vasyuchka V. I. , Serga A. A. , Hillebrands B. , Saitoh E. 
Published: November 2019

AbstractResonant enhancement of spin Seebeck effect (SSE) due to phonons was recently discovered in Y$${}_{3}$$

3

Fe$${}_{5}$$

5

O$${}_{12}$$

12

(YIG). This effect is explained by hybridization between the magnon and phonon dispersions. However, this effect was observed at low temperatures and high magnetic fields, limiting the scope for applications. Here we report observation of phonon-resonant enhancement of SSE at room temperature and low magnetic field. We observe in Lu$${}_{2}$$

2

BiFe$${}_{4}$$

4

GaO$${}_{12}$$

12

an enhancement 700% greater than that in a YIG film and at very low magnetic fields around 10$${}^{-1}$$

−
1

T, almost one order of magnitude lower than that of YIG. The result can be explained by the change in the magnon dispersion induced by magnetic compensation due to the presence of non-magnetic ion substitutions. Our study provides a way to tune the magnon response in a crystal by chemical doping, with potential applications for spintronic devices.
Packaging and delivering enzymes by amorphous metal-organic frameworks
Authors: Wu Xiaoling , Yue Hua , Zhang Yuanyu , Gao Xiaoyong , Li Xiaoyang , Wang Licheng , Cao Yufei , Hou Miao , An Haixia , Zhang Lin , Li Sai , Ma Jingyuan , Lin He , Fu Yanan , Gu Hongkai , Lou Wenyong , Wei Wei , Zare Richard N. , Ge Jun 
Published: November 2019

AbstractEnzymatic catalysis in living cells enables the in-situ detection of cellular metabolites in single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is packaged in amorphous metal-organic frameworks (MOFs) via a one-pot co-precipitation process under ambient conditions, exhibiting 5–20 times higher apparent activity than when the enzyme is encapsulated in corresponding crystalline MOFs. Molecular simulation and cryo-electron tomography (Cryo-ET) combined with other techniques demonstrate that the mesopores generated in this disordered and fuzzy structure endow the packaged enzyme with high enzyme activity. The highly active glucose oxidase delivered by the amorphous MOF nanoparticles allows the noninvasive and facile measurement of glucose in single living cells, which can be used to distinguish between cancerous and normal cells.
Transplanted interneurons improve memory precision after traumatic brain injury
Authors: Zhu Bingyao , Eom Jisu , Hunt Robert F. 
Published: November 2019

AbstractRepair of the traumatically injured brain has been envisioned for decades, but regenerating new neurons at the site of brain injury has been challenging. We show GABAergic progenitors, derived from the embryonic medial ganglionic eminence, migrate long distances following transplantation into the hippocampus of adult mice with traumatic brain injury, functionally integrate as mature inhibitory interneurons and restore post-traumatic decreases in synaptic inhibition. Grafted animals had improvements in memory precision that were reversed by chemogenetic silencing of the transplanted neurons and a long-lasting reduction in spontaneous seizures. Our results reveal a striking ability of transplanted interneurons for incorporating into injured brain circuits, and this approach is a powerful therapeutic strategy for correcting post-traumatic memory and seizure disorders.
Piezo1 channel activation mimics high glucose as a stimulator of insulin release
Authors: Deivasikamani Vijayalakshmi , Dhayalan Savitha , Abudushalamu Yilizila , Mughal Romana , Visnagri Asjad , Cuthbertson Kevin , Scragg Jason L. , Munsey Tim S. , Viswambharan Hema , Muraki Katsuhiko , Foster Richard , Sivaprasadarao Asipu , Kearney Mark T. , Beech David J. , Sukumar Piruthivi 
Published: November 2019

AbstractGlucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca2+ permeable cationic channel in a range of mammalian cells. As cell swelling induced insulin release could be through stimulation of Ca2+ permeable stretch activated channels, we hypothesised a role for Piezo1 in cell swelling induced insulin release. Two rat β-cell lines (INS-1 and BRIN-BD11) and freshly-isolated mouse pancreatic islets were studied. Intracellular Ca2+ measurements were performed using the fura-2 Ca2+ indicator dye and ionic current was recorded by whole cell patch-clamp. Piezo1 agonist Yoda1, a competitive antagonist of Yoda1 (Dooku1) and an inactive analogue of Yoda1 (2e) were used as chemical probes. Piezo1 mRNA and insulin secretion were measured by RT-PCR and ELISA respectively. Piezo1 mRNA was detected in both β-cell lines and mouse islets. Yoda1 evoked Ca2+ entry was inhibited by Yoda1 antagonist Dooku1 as well as other Piezo1 inhibitors gadolinium and ruthenium red, and not mimicked by 2e. Yoda1, but not 2e, stimulated Dooku1-sensitive insulin release from β-cells and pancreatic islets. Hypotonicity and high glucose increased intracellular Ca2+ and enhanced Yoda1 Ca2+ influx responses. Yoda1 and hypotonicity induced insulin release were significantly inhibited by Piezo1 specific siRNA. Pancreatic islets from mice with haploinsufficiency of Piezo1 released less insulin upon exposure to Yoda1. The data show that Piezo1 channel agonist induces insulin release from β-cell lines and mouse pancreatic islets suggesting a role for Piezo1 in cell swelling induced insulin release. Hence Piezo1 agonists have the potential to be used as enhancers of insulin release.
The effect of liver enzymes on adiposity: a Mendelian randomization study
Authors: Liu Junxi , Au Yeung Shiu Lun , Kwok Man Ki , Leung June Yue Yan , Lin Shi Lin , Hui Lai Ling , Leung Gabriel Matthew , Schooling C. Mary 
Published: November 2019

AbstractPoorer liver function is positively associated with diabetes in Mendelian randomization (MR) studies. Observationally, adiposity is associated with poorer liver function. To clarify the etiology, we assessed the association of liver enzymes with adiposity observationally and using two-sample MR for validation. In the “Children of 1997” birth cohort, we used multivariable linear regression to assess the associations of alanine transaminase (ALT) and alkaline phosphatase (ALP) at ~17.5 years with body mass index (BMI) (n = 3,458). Using MR, genetic predictors of ALT, ALP and gamma glutamyltransferase (GGT), were applied to genome-wide association studies of BMI (n = 681,275), waist circumference (WC) (n = 224,459) and waist-hip ratio (WHR) (n = 224,459) to obtain unconfounded estimates. Observationally, ALT was positively associated with BMI (0.10 kg/m2 per IU/L, 95% confidence interval (CI) 0.09 to 0.11). ALP was inversely associated with BMI (−0.018 kg/m2 per IU/L, 95% CI −0.024 to −0.012). Using MR, ALT was inversely associated with BMI (−0.14 standard deviation per 100% change in concentration, 95% CI −0.20 to −0.07), but not WC or WHR. ALP and GGT were unrelated to adiposity. Poorer liver function might not cause adiposity; instead higher ALT might reduce BMI, raising the question as to the role of ALT in body composition.