bluuebunny/crossref_metadata_2025_split huggingface dataset:
Program sketching with live bidirectional evaluation
Authors: Lubin Justin , Collins Nick , Omar Cyrus , Chugh Ravi 
Published: August 2020

We present a system called Smyth for program sketching in a typed functional language whereby the concrete evaluation of ordinary assertions gives rise to input-output examples, which are then used to guide the search to complete the holes. The key innovation, called live bidirectional evaluation, propagates examples "backward" through partially evaluated sketches. Live bidirectional evaluation enables Smyth to (a) synthesize recursive functions without trace-complete sets of examples and (b) specify and solve interdependent synthesis goals. Eliminating the trace-completeness requirement resolves a significant limitation faced by prior synthesis techniques when given partial specifications in the form of input-output examples.
To assess the practical implications of our techniques, we ran several experiments on benchmarks used to evaluate Myth, a state-of-the-art example-based synthesis tool. First, given expert examples (and no partial implementations), we find that Smyth requires on average 66% of the number of expert examples required by Myth. Second, we find that Smyth is robust to randomly-generated examples, synthesizing many tasks with relatively few more random examples than those provided by an expert. Third, we create a suite of small sketching tasks by systematically employing a simple sketching strategy to the Myth benchmarks; we find that user-provided sketches in Smyth often further reduce the total specification burden (i.e. the combination of partial implementations and examples). Lastly, we find that Leon and Synquid, two state-of-the-art logic-based synthesis tools, fail to complete several tasks on which Smyth succeeds.
Staged selective parser combinators
Authors: Willis Jamie , Wu Nicolas , Pickering Matthew 
Published: August 2020

Parser combinators are a middle ground between the fine control of hand-rolled parsers and the high-level almost grammar-like appearance of parsers created via parser generators. They also promote a cleaner, compositional design for parsers. Historically, however, they cannot match the performance of their counterparts.
This paper describes how to compile parser combinators into parsers of hand-written quality. This is done by leveraging the static information present in the grammar by representing it as a tree. However, in order to exploit this information, it will be necessary to drop support for monadic computation since this generates dynamic structure. Selective functors can help recover lost functionality in the absence of monads, and the parser tree can be partially evaluated with staging. This is implemented in a library called Parsley.
PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers
Authors: Graziani Edmund I. , Sung Matthew , Ma Dangshe , Narayanan Bitha , Marquette Kimberly , Puthenveetil Sujiet , Tumey L. Nathan , Bikker Jack , Casavant Jeffrey , Bennett Eric M. , Charati Manoj B. , Golas Jonathon , Hosselet Christine , Rohde Cynthia M. , Hu George , Guffroy Magali , Falahatpisheh Hadi , Finkelstein Martin , Clark Tracey , Barletta Frank , Tchistiakova Lioudmila , Lucas Judy , Rosfjord Edward , Loganzo Frank , O'Donnell Christopher J. , Gerber Hans-Peter , Sapra Puja 
Published: August 2020

Abstract
The approval of ado-trastuzumab emtansine (T-DM1) in HER2+ metastatic breast cancer validated HER2 as a target for HER2-specific antibody–drug conjugates (ADC). Despite its demonstrated clinical efficacy, certain inherent properties within T-DM1 hamper this compound from achieving the full potential of targeting HER2-expressing solid tumors with ADCs. Here, we detail the discovery of PF-06804103, an anti-HER2 ADC designed to have a widened therapeutic window compared with T-DM1. We utilized an empirical conjugation site screening campaign to identify the engineered ĸkK183C and K290C residues as those that maximized in vivo ADC stability, efficacy, and safety for a four drug–antibody ratio (DAR) ADC with this linker–payload combination. PF-06804103 incorporates the following novel design elements: (i) a new auristatin payload with optimized pharmacodynamic properties, (ii) a cleavable linker for optimized payload release and enhanced antitumor efficacy, and (iii) an engineered cysteine site–specific conjugation approach that overcomes the traditional safety liabilities of conventional conjugates and generates a homogenous drug product with a DAR of 4. PF-06804103 shows (i) an enhanced efficacy against low HER2-expressing breast, gastric, and lung tumor models, (ii) overcomes in vitro- and in vivo–acquired T-DM1 resistance, and (iii) an improved safety profile by enhancing ADC stability, pharmacokinetic parameters, and reducing off-target toxicities. Herein, we showcase our platform approach in optimizing ADC design, resulting in the generation of the anti-HER2 ADC, PF-06804103. The design elements of identifying novel sites of conjugation employed in this study serve as a platform for developing optimized ADCs against other tumor-specific targets.
Pegylated Engineered IL2 plus Anti–PD-1 Monoclonal Antibody: The Nectar Comes from the Combination
Authors: Rouanne Mathieu , Zitvogel Laurence , Marabelle Aurélien 
Published: August 2020

Abstract

Summary:
In this issue of Cancer Discovery, Diab and colleagues demonstrate in a phase I trial enrolling 38 patients diagnosed with advanced solid tumors that combining the pegylated IL2 bempegaldesleukin with an anti–PD-1 mAb is safe, with an overall response rate of 59.5%. This compelling clinical activity is supported by the potent immune proliferation and activation of circulating T and natural killer cells with a &gt;4-fold increase in the CD8/regulatory T-cell ratio in tumors, independent of baseline PD-L1 expression.
See related article by Diab et al., p. 1158.
Sanatório Barros Barreto (Belém-Pa)
Authors: Leal Larissa Silva , Miranda Cybelle Salvador 
Published: August 2020

A discussão a respeito do patrimônio cultural da saúde no Brasil tem se evidenciado nos últimos anos, principalmente a respeito dos desafios de valorização do patrimônio material e imaterial, dentre estes a arquitetura assistencial. O Hospital Universitário João de Barros Barreto (HUJBB) começou a ser construído no ano de 1938 como Sanatório Barros Barreto e, em 1976, deixa de ser sanatório, passando a ser chamado de Hospital Barros Barreto. Nesse momento, a instituição se torna também um local provedor de desenvolvimento da ciência por meio das pesquisas em agentes etiológicos das enfermidades incidentes na região amazônica. Este artigo tem por objetivo abordar a arquitetura do HUJBB enquanto patrimônio e,assim, entender os elementos arquitetônicos que contribuem para o modelo de tratamento que se propunha a abrigar no antigo sanatório paraense.
Music is not enough
Authors: Savasta Alsina Mene 
Published: August 2020

The first event in Argentina that ever included arte sonoro in its programming was Experimenta. Through its concerts and workshops, it was a milestone for the argentinean experimental music at the end of the 90s. Since its first edition in 1997, it challenged circles and procedures already stabilized in music, bringing together artists from different generations and sonic searches. It was in its year 2000 edition that the festival incorporated arte sonoro as one of its tags for the first time. What does it happen when it becomes necessary, from one moment to the next, to use a new expression to name an artistic activity?
That music is not enough is the hypothesis of this outline of the sound art history in Argentina, which aims to illuminate the foundational moment when that category arte sonoro began to be used in the programming of events and festivals.
From the observation of the textual framework around works and events -that is, catalogs, critical texts or press releases- we will see that, since 2000 in Argentina, the initial circulation of the expression arte sonoro shows what could be understood as musical origin, as a reaction to what was established, and as one of the features that contribute to the particular identity of early Argentine arte sonoro, in contrast with other histories -from other geographies- that usually link the origin of sound art with art installations and the participation of galleries and museums.
Inhuman Habitations
Authors: Little James 
Published: August 2020

Abstract
Taking as its starting point the proposition that Beckett’s closed spaces need a body in order to “go on,” this article examines the “production of space” in the confined habitations of Imagination Dead Imagine and All Strange Away. I use evidence from the “Fancy Dead Dying” Notebook to argue that the concept of “the human” remains central to Beckett’s production of closed space in All Strange Away. My conclusion highlights the importance of gender politics in the text’s production of space.
FIN DE PARTIE, György Kurtág / Samuel Beckett
Authors: de Ruyter Danièle 
Published: August 2020

Résumé
Avec Fin de partie : scènes et monologues, opéra en un acte, Győrgy Kurtág rend hommage à Beckett : non pas en accompagnant mais en réponse au texte, dont il n’ a été retenu qu’ une partie, la musique et le chant soulignant la recherche profondément beckettienne du silence et de l’ ailleurs. Pour cela Kurtág s’ appuie également sur les résonances créées par le poème “Roundelay,” autre œuvre beckettienne placée en prologue de l’ opéra.
Fonctions de l’ objet romanesque dans la première trilogie de Beckett
Authors: Courtois Martine 
Published: August 2020

Résumé
Dans la première trilogie de Beckett, la dissociation de l’ inventaire et des histoires met en cause le statut des objets et en perturbe toutes les fonctions habituelles. Accessoire, attribut, indice, objet d’ échange ou de quête, objet de savoir, aucune de ces qualités ne se vérifie. Enfin, l’ échec de l’ illusion référentielle réduit l’ inventaire à une nomenclature, et l’ histoire à une narrativisation de la liste. Mais comme le langage ne peut éliminer les signifiés, le roman abstrait reste irréalisable, car la res resurgit toujours derrière le rien.
“the earth is extinguished, though I never saw it lit”
Authors: Brower Emily R. 
Published: August 2020

Abstract
Samuel Beckett litters the text of his despairing post-apocalyptic drama with references to the book of Genesis. Beckett dissolves and diminishes the characters, plot, structure, and even syntax of Genesis as he undermines the world’s beginning in order to portray its end. Significantly, the allusions and references to Genesis are scattered and incoherent, replicating the disintegration of the world through their dissolute form. Endgame intentionally disseminates the texts, stories, and structures of Genesis—as well as its patriarchal family structure—amidst a chaotic, explosive deployment of the Bible itself. The text does more than allude to Genesis and reverse creation; it deconstructs the western world’s foundational text as an integral part of the world’s end.
Superficial Parotidectomy: Impact of Postoperative Drainage
Authors: Nielsen Charlotte Fog , Riis Charlotte Bjerg Sand , Christensen Anne Louise Bach , Mirz Frank , Reinholdt Kasper Basse , Ovesen Therese , Fjaeldstad Alexander Wieck 
Published: August 2020

Background: Use of suction drain after superficial parotidectomy (SP) is based on national consensus considered best practice, but there is no evidence on the effect of the treatment. The aim of the present study is to evaluate the effectiveness of drainage after SP by evaluating the rate of complications after SP in relation to the (ie, duration) of drainage and tumor size. Methods: Retrospective analysis was performed involving data from all consecutive patients undergoing SP at the Ear, Nose, and Throat department, Regional Hospital West Jutland, Denmark, between January 1, 2011, and December 31, 2017. Demographics including comorbidity, medication, tumor size, postoperative secretion through the drainage, as well as complications (hematoma, seroma, infection, fistulas, Frey syndrome, facial nerve palsy) were registered. Patients with secretion below 25 mL were compared to patients with secretion above 25 mL, that is, drainage less than 24 hours versus longer than 24 hours. Results: Two hundred five consecutive patients undergoing SP were enrolled. The overall risk of postoperative infection was 16.2%. Ten of 33 patients with infection were also diagnosed with an hematoma or seroma. The risk of infection increased with secretion above 25 mL (27.2%) compared to patients with less than 25 mL (13.1%; P = .0318). The same accounts for the risk of seromas/hematomas ( P = .0055). We found no evidence that demographics or comorbidity correlated to the secretion in the drainage, but there is a tendency toward male gender having a higher risk off secretion above 25 mL (odds ratio 1.39). Conclusion: Overall, the risk of complications after SP increased with secretion beyond 25 mL (ie, drainage for more than 24 hours). This applied in particular to infections and seromas/hematomas demanding treatment. The use of routine drainage after SP is questionable, and a randomized trial is warranted to unravel the necessity of postoperative drainage.
Are Dental Maturation, Skeletal Maturation, and Chronological Age Associated With Complete Cleft Lip and Palate?
Authors: Ozturk Taner , Gumus Husniye , Ozturk Gulce 
Published: August 2020

Objective: The relationship between dental and skeletal development levels was determined in individuals with cleft lip and palate and a control group comprising individuals without cleft lip and palate. Design: Retrospective, cross-sectional study. Setting: A university clinic specializing in orthodontic and pedodontic care. Patients: A total of 198 patients with cleft lip and palate (99 females, 11.66 ± 2.36 years; 99 males, 12.44 ± 2.33 years) and 198 patients without cleft lip and palate (99 females, 11.88 ± 2.26 years; 99 males, 12.99 ± 2.25 years). Interventions: None. Main Outcome Measures: The Demirjian method and cervical vertebra maturation method were used to evaluate panoramic and lateral cephalometric radiographs, respectively. The Fishman maturation predictors were determined from hand-wrist radiographs. Results: Statistically significant correlations were found between the chronological age and the dental age in both the groups ( P < .05). Significant correlations between skeletal maturation indicators and dental maturation indicators were observed in both groups and sexes ( P < .05), with a stronger correlation among teeth with incomplete dental maturation. Dental age was found to be significantly lower (female, P = .001; male, P = .001) in individuals with cleft lip and palate (female, 11.71 ± 2.58 years; male, 12.51 ± 2.62 years) compared to those in the control group (female, 12.95 ± 2.47 years; male, 13.64 ± 2.37 years). Conclusions: A high correlation between the results of the evaluated radiographic methods and chronological age supports their use for accurate age estimation in the patients with cleft lip and palate.
Continuation of aspirin therapy before pars plana vitrectomy: Safe or not?
Authors: Wang Jin , Li Qingjian , Zhang Yu , Che Xin , Jiang Jing , Qian Yiwen , Wang Zhiliang 
Published: August 2020

Purpose: To assess the safety of pars plana vitrectomy (PPV) in patients undergoing systemic treatment with aspirin. Methods: This prospective study enrolled consecutive patients undergoing PPV under percutaneous retrobulbar anesthesia between February 2016 and July 2018. Sixty-seven eyes from 67 patients on regular aspirin therapy were randomized into two groups: the continuation group (33 eyes), with aspirin continued during the perioperative period; and the discontinuation group (34 eyes), with aspirin discontinued for 3 to 7 days before surgery. Forty-three eyes from 43 patients who had no antiplatelet/anticoagulant therapy were used as a control group. Results: There was no significant difference in the incidence of hemorrhagic complications or the need for additional operations due to hemorrhagic complications among the three groups ( p = 0.740 and p = 0.324, respectively). None of the patients in these three groups suffered from thromboembolic events during the follow-up period. Except for one case (3.0%) of lid ecchymosis in the continuation group, no eye experienced bleeding complications associated with the retrobulbar local anesthesia. In the continuation group, three eyes (9.1%) demonstrated postoperative hyphema that resolved spontaneously. In the discontinuation group, two eyes (5.9%) suffered from postoperative vitreous hemorrhage, of which one eye required secondary surgery and the other cleared spontaneously. One eye (2.9%) in the discontinuation group demonstrated postoperative hyphema that absorbed spontaneously. Three eyes (7.0%) in the control group experienced hyphema that absorbed spontaneously. Conclusion: The outcomes of our study indicate that PPV under retrobulbar anesthesia can be safely performed without discontinuing systemic aspirin therapy.
Extreme corneal flattening following collagen crosslinking for progressive keratoconus
Authors: Padmanabhan Prema , Belin Michael W , Padmanaban Vasanthi , Sudhir Rachapalle Reddi 
Published: August 2020

Purpose: To study the clinical, tomographic and densitometric features of eyes that showed >5 D of corneal flattening following collagen crosslinking (CXL) for progressive keratoconus and to identify preoperative predictive factors for such a response. Methods: This was a retrospective case control study of 548 eyes with progressive keratoconus which had undergone epithelium-off CXL (Dresden protocol) with a follow-up of 1 to 10 years. Eyes that showed ⩾5 D corneal flattening in maximum keratometry (Kmax) following CXL (group A) were compared with one eye of the remaining patients in the same cohort (group B). Changes in refraction and visual acuity, Kmax and thinnest pachymetry were compared between both groups. Univariate and multivariate regression analysis identified preoperative risk factors for unusual corneal flattening. Results: Forty three eyes in group A were compared with 502 eyes in group B. At the time of maximum flattening, group A showed more flattening (−7.6 ± 3.2 D) and thinning (−53.7 ± 45.2 µ) than group B (−1.69 ± 2.9 D and −26.6 ± 36.7 µ, respectively). Multivariate analysis based on parameters suggested by a univariate regression analysis identified pre-op Kmax to be the most significant predictor of intense corneal flattening. A subgroup analysis of K-matched eyes revealed that the duration of time following CXL was a significant risk factor for extreme corneal flattening following CXL Conclusion: An intense corneal flattening >5 D in Kmax was documented in 7.85% of a cohort of keratoconus patients who underwent CXL. High preoperative Kmax and the duration of time following CXL were significant predictors of this response which was accompanied by significant corneal thinning.
Making Knowledge Hereditary: Public–Private Partnership Drives Progress in Rare Disease Community
Authors: Mulally Amanda , Bias Val , Konkle Barbara , Watson Crystal , Yellen Ilana , Maxwell Allison 
Published: August 2020

Background: Hemophilia is a rare and complex inherited bleeding disorder in which people may experience prolonged, painful, and debilitating bleeds due to an inability of their blood to clot properly. Although there has been great progress in the management of the disease over the past 50+ years, many important scientific questions have gone unanswered. Further, despite decades-long interest and desire by medical providers and scientists, the U.S. government and the hemophilia community to conduct comprehensive genetic testing to better understand the disorder, challenges such as cost, access, and privacy concerns served as ongoing obstacles. Focus of the Article: To overcome these challenges and address this unmet need, four community organizations and a health communications and social marketing agency came together in 2011 to create a first-of-its kind public–private partnership (PPP) called My Life, Our Future (MLOF) to provide people with hemophilia information about their disorder while also furthering scientific understanding. Importance to the Social Marketing Field: This article will explain how MLOF utilized social marketing to drive broad community engagement, ultimately genotyping more than one third of the U.S. male hemophilia population through the program and opening the MLOF Research Repository, the largest research repository of its kind. It will also discuss the key learnings gleaned through the establishment and implementation of this program, notably the strength of a PPP in health care.
ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma
Authors: Sun Hongmei , Zhang Mingying , Li Li , Huang Zongwen 
Published: August 2020

Background: Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common type of lung cancer. Although emerging evidence implicates the role of several aldehyde dehydrogenases in cancer progression, the expression and clinical significance of aldehyde dehydrogenase 3B1 in lung adenocarcinoma has never been studied. Materials: In our study, the expression of aldehyde dehydrogenase 3B1 in 250 cases of lung adenocarcinoma was detected with immunohistochemistry, and the patients were further divided into subgroups with different aldehyde dehydrogenase 3B1 expression. Using real-time polymerase chain reaction, we investigated the aldehyde dehydrogenase 3B1 messenger RNA in 20 lung adenocarcinoma and paired normal lung tissues. With the χ2 test, we evaluated the clinical significance of aldehyde dehydrogenase 3B1 by analyzing its correlation with the clinicopathological factors. Propensity score matching was performed to balance the baseline of cohort. With univariate and multivariate analyses, we screened the prognostic factors of lung adenocarcinoma and identified the independent prognostic factors before and after the propensity score matching. Results: Aldehyde dehydrogenase 3B1 expression was significantly associated with the sex and age of patients, tumor size, and histological grade. High expression of aldehyde dehydrogenase 3B1 predicted the poor prognosis ( P = .003). Moreover, male patients ( P = .020), large tumor size ( P = .009), advanced T stage ( P = .001), positive lymphatic invasion ( P < .001), and advanced tumor–node–metastasis stage ( P < .001) were all the prognostic factors for unfavorable outcome. Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the poor prognosis. In addition, after balancing the baseline characteristics by propensity score matching, we also demonstrated that aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma ( P = .007). Conclusions: Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the unfavorable prognosis. Postoperative detection of aldehyde dehydrogenase 3B1 would help stratify the high-risk patients with lung adenocarcinoma and guide individual treatment.