bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Penentuan Jalur Lokasi Penjemputan Mengunakan Algoritma Dijkstra Berbasis Mobile
Authors: Fadlil Abdul , Riadi Imam , Saefuloh Moh 
Published: March 2020

Penentuan rute optimal merupakan suatu masalah yang sangat penting untuk dipecahkan karena berpengaruh terhadap waktu dan biaya operasional kendaraan. Penentuan rute optimal diperlukan untuk mendapatkan rute yang efisien. Salah satu permasalahan dalam penentuan jalur lokasi penjemput siswa di SMK Muhammadiyah Bumiayu, Kab. Brebes, Jawa Tengah itu sendiri dalam penetuan jalur lokasi penjemputan dengan menggunakan Algoritma Dijkstra. Di dalam Dijkstra itu sendiri merupakan salah satu algoritma yang digunakan untuk mencari jarak terpendek, untuk menentukan jalur lokasi penjemput antar siswa. Pengembangan sistem informasi yang dibuat dengan menggunakan Android digunakan untuk penentuan jalur lokasi penjemput siswa (Halte). Hasil yang didapatkan dari penentuan jalur lokasi penjemputan siswa adalah mampu menemukan jarak terpendek dan jarak terpendek alternatif ketika terjadi hambatan (pemblokiran jalan dan Kemacetan) pada jalur terpendek utama dan juga dapat mengetahui estimasi waktu tempuhnya. Tujuannya dan manfaat dengan adanya aplikasi penentuan jalur lokasi penjemputan dengan menggunakan Algoritma Dijkstra berbasis mobile adalah untuk menentukan efesiensi rute penjemputan berdasarkan halte sekolah, waktu tempuh dan jumlah penumpang sedangkan Manfaat adalah untuk mengguranggi angka indek keterlambatan siswa, memberikan kemudahan akses kepada siswa-siswi SMK Muhammadiyah Bumiayu untuk pepesanan penjemputan, memberikan efisiensi waktu penjemputan siswa dan meningkatkan nilai jual SMK Muhammadiyah Bumiayu.
Rancang Bangun Sistem Informasi Jasa Proyek (SiJasPro) berbasis Mobile
Authors: Hasanudin Muhaimin , Kristiadi Dedy Prasetya , Roihan Ahmad , Haris Haris 
Published: March 2020

Kemajuan teknologi informasi memudahkan penjual dalam mempromosikan barang, konsumen dapat mencari material yang dibutuhkan. Namun terdapat masalah dalam membangun atau renovasi rumah yakni saat mencari material dan tukang bangunan dalam satu sistem. maka dibutuhkan rancang bangun Sistem Informasi Jasa Proyek disingkat SiJasPro. SiJasPro bertujuan untuk mempermudah konsumen dalam mencari material dan tukang bangunan, membeli kebutuhan material dan mencari tukang bangunan sesuai anggaran yang tersedia. Dalam mengembangkan aplikasi SiJasPro memanfaatkan android visual studio, selain itu, digunakan metode Rapid Application Development (RAD) dengan pendekatan berorientasi objek untuk menghasilkan sebuah sistem dengan sasaran utama mempersingkat waktu pengerjaan secara tepat dan cepat yang terdiri dari tahap requirement planning, design system, instruction dan implementation. Hasil rancang bangun sistem dapat mengintegrasikan konsumen, penjual dan tukang bangunan dalam satu sistem, mempermudah para pengguna sistem dalam mengakses informasi dan mengelola data secara terkomputerisasi. Aplikasi dapat diakses melalui web maupun Android.
Analysis of the Financial Performance of PT Garuda Indonesia from the Period 2012 to 2018
Authors: Priyadi Aswin , Maupa Haris , Rasyid Wahda 
Published: March 2020

Commercial aviation is a part of aviation industry which specializes in operating aircraft for passenger and cargo. PT Garuda Indonesia is a one flag carrier that has a worldwide reputation in aviation industry. This study analyzes the financial performance of the Indonesian aviation industry, with specific reference to the PT. Garuda Indonesia, Tbk for the period 2012-2018. This research uses descriptive type of research. The data required in this research is collected based on secondary data. The financial performance has been explored to support this study by analyzing the financial statements throughout 2012-2018. The data collected from the company’s prospectus, annual reports, and other sources to help the researcher to analyze the financial performance. The financial ratios which are used in this research are liquidity ratio, profitability ratio, and solvency ratio to determine the financial performance each year. Continue using DuPont Analysis, Compound Annual Growth Method (CAGR), and Optimal Capital Structure and SWOT Analysis. In the last 5 years PT. Garuda Indonesia experience once significant performance degradation in 2014, where the number of total operating expenses were higher than the total operating revenues. It was found that Garuda Indonesia currently suffering from high loss. A significant change is noticed in 2014 where net income fell up to 90%. In 2017 Garuda Indonesia also suffering too, which is the profit loss till US $ 213 million. This means the net income was not able to cover its expenses at that time. This event is occurred due to the rising domestic jet fuel price and depreciation of Indonesian local currency. The result of this analysis will be given to PT. Garuda Indonesia, Tbk. to improve the financial performance of the company and can be used as a reference for other airline to study financial performance of other airlines.
ANALISIS REBRANDING UNTUK MEMBENTUK FAVORABLE BRAND IMAGE PADA RADIO PLAY 99ers
Authors: Indika Deru R , Dewi Windy Utami 
Published: March 2020

Penelitian ini membahas hasil analisis pelaksanaan rebranding pada “Play 99ers” Radio Bandung. Tujuan penelitian untuk mengetahui mengenai pelaksanaan rebranding dan keputusan perusahaan untuk melakukan rebranding termasuk keputusan yang tepat atau tidak. Faktor pendorong perusahaan melakukan rebranding adalah karena pergantian kepemilikan, pelaksanaan rebranding yang dilakukan oleh perusahaan adalah mengubah positioning, nama, desain logo, dan cara komunikasi. Dimensi pengukuran analisis rebranding yang digunakan dalam penelitian ini yaitu brand repositioning, brand renaming, brand redesigning dan brand relaunching.Metode penelitian yang digunakan dalam penelitian ini adalah survey dengan metode deskriptif. Teknik pengumpulan data yang digunakan adalah studi kepustakaan, observasi, dan kuesioner. Sampel diambil dari 100 orang responden yang pernah mendengarkan “Play 99ers” Radio Bandung yang diambil dengan menggunakan teknik purposive sampling. Hasil penelitian menunjukkan rebranding yang dilakukan merupakan keputusan yang tepat karena mendapat tanggapan baik dari masyarakat.
ANALISIS DANA ALOKASI KHUSUS TERHADAP PERTUMBUHAN EKONOMI DAN INDEKS PEMBANGUNAN MANUSIA DI PROVINSI SULAWESI SELATAN
Authors: Amir Ismayani 
Published: March 2020

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh DAK bidang pendidikan terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan; pengaruh DAK bidang kesehatan terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan; pengaruh DAK bidang lain-lain terhadap indeks pembangunan manusia (IPM) secara langsung atau melalui pertumbuhan ekonomi pada kabupaten/kota di Provinsi Sulawesi Selatan;dan pengaruh pertumbuhan ekonomi terhadap indeks pembangunan manusia (IPM) pada kabupaten/kota di Provinsi Sulawesi Selatan. Data yang digunakan dalam penelitian ini adalah data sekunder, yaitu data yang diperoleh dari Dirjen Perimbangan Keuangan Pemerintah Daerah (DJPKD) dan Badan Pusat Statistik (BPS). Jenis data yang digunakan adalah pooled data (data panel) yang merupakan gabungan data time series yaitu tahun 2010 sampai 2016 dan data cross section yaitu 24 kabupaten/kota, dengan menggunakan analisis regresi data panel dengan bantuan program Eviews 9. Hasil penelitian menunjukkan bahwa: Pertama, DAK bidang pendidikan secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang pendidikan terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Kedua, DAK bidang kesehatan secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang kesehatan terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Ketiga, DAK bidang lain-lain secara langsung berpengaruh signifikan terhadap IPM dan secara tidak langsung pengaruh DAK bidang lain-lain terhadap IPM dapat dimediasi melalui pertumbuhan ekonomi. Keempat, pertumbuhan ekonomi berpengaruh signifikan terhadap IPM. Kata kunci: Dana alokasi khusus (DAK) bidang pendidikan, kesehatan, lain-lain, pertumbuhan ekonomi, IPM, Sulawesi Selatan.
La Homeopatía incrementa la tolerancia al estrés por NaCl en plantas de frijol común (Phaseolus vulgaris L.) variedad Quivicán
Authors: Mazón Suástegui José Manuel , Ojeda Silvera Carlos Michel , García Bernal Milagro Ramona , Batista Sánchez Daulemys , Abasolo Pacheco Fernando 
Published: March 2020

Currently, the international scientif ic community is increasingly promoting the use of alternatives eco-friendly to the environment to solve agricultural problems, such as soil salinization. The use of agricultural homeopathy, as one of these alternatives, has increased because of its safety and proven effectiveness. This study assessed the effect of attenuating salinity stress (NaCl) of the homeopathic medicine Natrum muriaticum (NaM) on photosynthetic rate (TF) and morphometric variables of the common bean plant (Phaseolus vulgaris L.) variety white testa Quivican in initial plant growth stage. A completely randomized experimental design was applied with bifactorial arrangement (2A × 4B) where A = salinity levels (0 and 75 mM) and B = homeopathic dynamizations (NaM-7CH, NaM-13CH, NaM-7+13CH and distilled water [AD] as homeopathic control) with f ive replicates per treatment. The TF measurements were done twice a week, and the morphometric variables were measured at the end of the experimental evaluation period (35 days). In general, the assessed morphometric variables were favored with the application of the homeopathic treatments NaM 7CH and NaM 7+13CH; the increase in root length (LR) and fresh leaf biomass (BFH) were greater even when the plants were in salinity stress conditions (75mM NaCl). The TF reached the highest value when the plants in saline medium were treated with NaM-7CH, and an increase greater than 50% in PR was observed with respect to the (AD) control treatment. These results demonstrated a great potential of agricultural homeopathy as a bio-safe and low-cost alternative to increase P. vulgaris L. tolerance to NaCl and achieve greater areas of this crop.
Histamine test kit formation from Manganase (II), 5-fluorouracil and Alizarin red S complex compound
Authors: Sholehah Hijriati , Susane Hismi 
Published: March 2020

This researh aims to detect the presence of histamine by forming complex compounds of 5-fluorouracil, Mn (II) metal ions and alizarin red S reagents. This type of research is a laboratory experiment. This research was conducted at the Ikip Chemistry Laboratory in 2019. The results showed that the Test Kit that was made could be used to detect the presence of histamine determining the existence of histamine qualitatively viewable color formed based on complex compounds ofÃÂ Mn(II)-His-5FU-ARS seen from the shift in wavelength of maximum generated.. The making of the histamine test kit is made by varying the concentration of 10-100 ppm at 10 ppmÃÂ ÃÂ intervals under optimum conditions and can be used to make a color comparator solution. ThenÃÂ the method validity test is done by making a standard histamine curve that gives a regression equationÃÂ y = 0.001x + 0.3364 with a correlation coefficient (r2) = 0.9972. Based on the validity test method, the accuracy value is in the range ofÃÂ 95.0-106% and the results of the test kit on tuna samples indicate that the histamine test kit made has a good accuracy value because the average recovery value is 96%.ÃÂ
Penerapan Metode Problem Based Learning Untuk Meningkatkan Hasil Belajar Biologi Mata Pelajaran Lintas Minat
Authors: Ilhamdi Mohammad Liwa , Santoso Didik , Astuti Sri Prapti 
Published: March 2020

Penelitian ini bertujuan untuk menerapkan metode problem based learning untuk meningkatkan hasil belajar Biologi siswa kelas X IPS Unggulan ÃÂ tahun 2018-2019. Jenis penelitian ini adalah penelitian tindakan kelas (PTK). ÃÂ Variabel tindakan dalam penelitian ini adalah metode problem based learning sedangkan variabel harapannya adalah hasil belajar biologi. ÃÂ SubyekÃÂ dalam penelitian ini adalah siswa kelas X IPS Unggulan MAN 2 Mataram berjumlah 37 orang. Penelitian berlangsung 2 siklus. Masing-masing siklus terdiri dari tahap perencanaan, pelaksanaan, observasi dan refleksi. Instrumen yang digunakan dalam penelitian ini adalah ÃÂ lembar observasi dan lembar tes. Hasil penelitian menunjukkan bahwa pada siklus I ÃÂ kegiatan ÃÂ pembelajaran problem based learning yang dilakukan guru memperoleh skor 12 kategori cukup baik, aktivitas siswa kategori cukup aktif sedangkan ketuntasan belajar klasikal 78,3% kategori belum memenuhi KKM. Pada siklus ke II skor kegiatan ÃÂ guru memperoleh skor 17 ÃÂ kategori baik, aktivitas siswa memperoleh skor 13 kategori aktif dan ketuntasan klasikal 86%. Kesimpulan penelitian ini adalah penerapan metode problem based learning dapat meningkatkan hasil belajar Biologi siswa kelas X IPS Unggulan MAN 2 Mataram tahun pelajaran 2018-2019.
3.3 Age- and Sex-specific Reference Intervals for Brachial Artery Flow-mediated Dilation in Healthy Individuals and the Relation with Cardiovascular Risk Factors
Authors: Holder Sophie , Bruno Rosa Maria , Shkredova Daria , Thompson Andrew , Dawson Ellen , Jones Helen , Hopkins Nicola , Hopman Maria , Bailey Tom , Coombes Jeff , Askew Christopher , Naylor Louise , Maiorana Andrew , Ghiadoni Lorenzo , Green Daniel , Thijssen Dick 
Published: March 2020

Abstract
Background
Assessment of endothelial function using brachial artery flow-mediated dilation (FMD) predicts future cardiovascular disease (CVD) risk. However, poor adherence to protocol guidelines and lack of reference values hinders widespread FMD use. This study established age- and sex-specific reference intervals for brachial artery FMD in healthy individuals and examined the relation with CVD risk factors.

Methods
Collected according to expert-consensus guidelines, we combined brachial artery FMD and subject characteristics/medical history from 5,362 individuals (4–84 years; 2,076 females). We first examined healthy individuals (n = 1,403 [582 females]) to generate age-/sex-specific percentile curves. Subsequently, we included subjects with CVD risk factors but without disease (un-medicated n = 3,167 [1,247 females], and medicated n = 792 [247 females]). Multiple linear regression tested the relation of CVD risk factors with FMD.

Results
Healthy men showed a negative, curvilinear relation between FMD and age, whilst females revealed a linear relation that started higher, but declined at a faster rate. Age-/sex-related differences in FMD, at least partly, relate to baseline artery diameter. FMD was affected by CVD risk factors in un-medicated (e.g. systolic-/diastolic blood pressure, diabetes) and medicated subjects (e.g. dyslipidaemia). Importantly, sex mediated these effects (p < 0.05), with (supra) normalisation of FMD in medicated men, but not in women (except for blood pressure).

Conclusion
Sex alters the age-related decline in FMD, which is partly explained through differences in artery diameter. Sex also altered the effect of some CVD risk factors and medication on FMD. This work improves interpretation and future use of the FMD technique when strictly adhering to FMD protocol guidelines.
3.6 Fitness, Fatness and Exercise Blood Pressure in Adolescence
Authors: Huang Zhengzheng , Park Chloe , Chaturvedi Nishi , Howe Laura , Sharman James , Hughes Alun , Schultz Martin 
Published: March 2020

Abstract
Objective
Exaggerated exercise blood pressure (BP) is associated with cardiovascular risk factors in adolescence. Aerobic fitness and adiposity (fat mass or ‘fatness’) are important independent contributors to cardiovascular risk in adolescence, but their interrelated associations with exercise BP are unknown. The aim of this study was to determine the respective relationship between fitness, fatness and exercise BP in a large birth cohort of adolescents.

Methods
2356 adolescents from the Avon Longitudinal Study of Parents and Children (aged 17.8 ± 0.4 years, 38.5% male) completed a submaximal exercise step-test that allowed fitness (VO2max) to be determined from workload and heart rate using a validated equation. Exercise BP was measured immediately on test cessation and fatness calculated as the ratio of total fat mass to total body mass measured by DXA.

Results
Exercise systolic BP decreased stepwise with each tertile of fitness (146 [144, 147]; 142 [141, 144]; 141 [139, 142] mmHg), but increased with each tertile of fatness (137 [135, 138]; 143 [142, 144]; 148 [147, 149] mmHg). In separate models, fitness and fatness were independently associated with exercise systolic BP after adjustment for sex, age, height, smoking and socioeconomic status (standardised β : −1.97, 95% CI: −2.90, −1.04 mmHg/SD and 5.69, 95% CI: 4.61, 6.77 mmHg/SD respectively). However, when fitness and fatness were included in the same model, only fatness remained independently associated with exercise BP (6.15, 95% CI: 4.88, 7.41 mmHg/SD).

Conclusion
Both fitness and fatness are associated with exercise BP in adolescence. However, the fitness-exercise BP association was not independent of fatness, suggesting fatness accounts for the association with exercise BP.
5.4 Acute Effects of Indapamide Treatment on Haemodynamics and Glycosaminoglycan-Mediated Non-Osmotic Skin Sodium Storage in Healthy Humans
Authors: Connolly Kathleen , Selvarajah Viknesh , McEniery Carmel , Wilkinson Ian 
Published: March 2020

Abstract
Introduction
The skin may protect against the adverse haemodynamic effects of dietary salt by storing excess sodium in an osmotically inactive form, bound to glycosaminoglycans. However, this novel pathway has not been comprehensively studied in humans.

Methods
85 healthy volunteers (37 m, 48 f) <50 years of age underwent a one-week run-in to standardise dietary salt intake, before random allocation to either placebo or 2.5 mg indapamide diuretic for eight days. Total body water (TBW), peripheral blood pressure, pulse wave velocity (PWV), stroke volume (SV), cardiac output (CO), and skin biopsies were taken before and after treatment. PWV was measured using SphygmoCor, while SV and CO were measured by inert gas rebreathing. 5 mm skin biopsies were taken from the lower back using sodium-free lignocaine. Biopsies were freeze-dried to establish water content, and sodium content was quantified using inductively coupled plasma — optical emission spectroscopy. Glycsosaminoglycan content was assessed by qPCR. Data were analysed using repeated measures ANOVA.

Results
Following indapamide treatment, skin sodium fell by 10% (p = 0.004) with no reduction in skin water content, compared to placebo. There were no significant differences in blood pressure or PWV between groups. TBW, SV, and CO were significantly reduced by indapamide compared to placebo (p < 0.001, p < 0.01, p < 0.01, respectively), whilst systemic vascular resistance increased (p < 0.001). Glycosaminoglycan mRNA expression decreased (p < 0.05).

Conclusion
This diuretic-induced reduction in skin sodium content and glycomsaminoglycan expression, without commensurate water loss, suggests a release of sodium from osmotically inactive skin stores. This is the first comprehensive evidence of glycosaminoglycan-regulated non-osmotic skin sodium storage in humans, with implications for salt-sensitive hypertension.
P2 Calcium Induced Intramitochondrial cAMP Signalling Enhances Aldosterone Secretion
Authors: Szanda Gergő , Wisniewski Éva , Rajki Anikó , Spät András 
Published: March 2020

AbstractElevation of plasma [K+] and [angiotensin II] (Ang II), two major physiological stimuli of adrenal zona glomerulosa cells, increase aldosterone production by triggering cytosolic Ca2+ signalling. Cytosolic Ca2+ signals are accompanied by mitochondrial Ca2+ elevations which further strengthen this steroidogenic response. It has recently been recognized that such mitochondrial Ca2+ signals activate the mitochondrial soluble adenylyl cyclase (sAC) thus evoking intramitochondrial (matrix) cAMP elevations during Ca2+ signalling. We hypothesised that this Ca2+ induced mitochondrial cAMP production, too, contributes to the hypersecretion of aldosterone. Using human adrenocortical H295R cells we found that silencing of sAC decreased mitochondrial cAMP production and, at the same time, decelerated Ca2+ accumulation by the organelle. On the other hand, inhibition of the mitochondrial phosphodiesterase (PDE2A) intensified matrix cAMP production and accelerated mitochondrial Ca2+ uptake. More importantly, both pharmacological inhibition and knock-down of sAC mitigate AngII-induced aldosterone production. Finally, overexpression of wild-type sAC within the mitochondrial matrix increased mitochondrial cAMP formation, accelerated mitochondrial Ca2+ uptake and, most prominently, potentiated aldosterone production as compared to the enzymatically inactive mutant enzyme. Altogether, Ca2+-induced mitochondrial cAMP signalling supports aldosterone production by favouring additional Ca2+ influx into the organelle. This positive feed-back loop may expedite the hormonal response when immediate hypersecretion of mineralocorticoids is crucial for cardiovascular compensation (e.g. exsiccation, blood loss).
P3 Factor Influencing Endothelial Function in Type 2 Diabetes Mellitus with Newly Diagnosed Hypertension
Authors: Srivastava Prachi 
Published: March 2020

Abstract
Background
Increased risk for cardiovascular diseases is associated with diabetes, can be partially attributed to endothelial dysfunction. However, the cumulative factors leading to endothelial dysfunction in Type 2 DM are not clear. In the current study, a novel attempt was made to understand factors influencing endothelial function (EF) in humans using Angiotensin Converting Enzyme (ACE) inhibition as a tool to alter EF.

Methods
Brachial Flow-mediated-dilation (FMD) was measured using ultrasonography in 60 diabetics with newly-diagnosed hypertension. Serum E-selectin, Vascular-Cell-Adhesion-Molecule-1 (VCAM-1), hsCRP, IL-10, Renin, Ang 1–7, Ang II and ACE 2 were measured using ELISA. Amplitude of change, calculated as absolute difference in values obtained at baseline (V1) from those after 3 months (V3) (V3−V1), of biomarkers were correlated with change in FMD and E-selectin after 3 months of ACE inhibition.

Results
FMDV3-V1 showed significant negative correlation with hsCRPV3-V1, FSV3-V1, PPSV3-V1 and HbA1cV3-V1 [(r = −0.3, p = 0.02), (r = −0.31, p = 0.01), (r = −0.27, p = 0.03) (r = −0.3, p = 0.02), respectively] and significant positive correlation with Ang1–7V3-V1 (r = 0.39, p = 0.002). E-selectin correlated positively with FSV3-V1, PPSV3-V1 , HbA1cV3-V1, VCAM-1V3-V1 and ReninV3-V1 [(r = 0.35, p = 0.006), (r = 0.32, p = 0.01), (r = 0.45, p = 0.0005), (r = 0.66, p < 0.001), (r = 0.53, p < 0.0001) respectively].

Conclusion
A balance between the Renin/ Ang II and Ang 1–7/ACE2 axis plays a significant role in EF. Additionally, reduction in blood sugar levels and vascular inflammation also improves EF.