bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparing for the future of public health: ecological determinants of health and the call for an eco-social approach to public health education
Authors: Parkes Margot W. , Poland Blake , Allison Sandra , Cole Donald C. , Culbert Ian , Gislason Maya K. , Hancock Trevor , Howard Courtney , Papadopoulos Andrew , Waheed Faiza 
Published: December 2019

AbstractAs a collective organized to address the education implications of calls for public health engagement on the ecological determinants of health, we, the Ecological Determinants Group on Education (cpha.ca/EDGE), urge the health community to properly understand and address the importance of the ecological determinants of the public’s health, consistent with long-standing calls from many quarters—including Indigenous communities—and as part of an eco-social approach to public health education, research and practice. Educational approaches will determine how well we will be equipped to understand and respond to the rapid changes occurring for the living systems on which all life—including human life—depends. We revisit findings from the Canadian Public Health Association’s discussion paper on ‘Global Change and Public Health: Addressing the Ecological Determinants of Health’, and argue that an intentionally eco-social approach to education is needed to better support the health sector’s role in protecting and promoting health, preventing disease and injury, and reducing health inequities. We call for a proactive approach, ensuring that the ecological determinants of health become integral to public health education, practice, policy, and research, as a key part of wider societal shifts required to foster a healthy, just, and ecologically sustainable future.
Efficacy of Mindfulness Based on Cognitive Therapy on Impulsivity and Self- Inhibition in Patients with Bipolar Disorder under Medical Treatment
Authors: Kazemi-Zahrani Hamid , Mohagheghian Malihe 
Published: December 2019

Introduction: Bipolar disorder is combined with chronic symptoms that have effect on cognitive abilities and executive functions. The purpose of present study was to investigate efficacy of mindfulness based cognitive therapy (MBCT) on impulsivity and self-inhibition in the patients with bipolar disorder under medical treatment.
Methods: This study was quasi-experimental, pretest-posttest design with the control group. 30 men and women with bipolar disorder referred to psychiatry center of Almahdi Welfare in Esfahan were selected through convenience sampling method and assigned in two groups: experimental (14) and control (16) randomly. Both groups performed behavioral impulsivity scale (BIS-11) and self-inhibition scale (SRS) in the pretest and posttest phases. Experimental group was treated with mindfulness based cognitive therapy (MBCT) for 8 sessions. The data were analyzed by MANCOVA.
Results: Covariate analyze demonstrated that of mindfulness based cognitive therapy (MBCT) was effective on reducing the impulsivity and increasing the self-inhibition in the experimental group.
Conclusion: Based on this finding, reduce cognitive impulsivity and motor impulsivity, and increase self-inhibition in anger control, impulse control and respect for others dimensions, is because of mindfulness based on cognitive therapy. Considering psychological intervention based on mindfulness, in addition to medical treatment is of particular importance.
Ketogenic Diet for Refractory Childhood Epilepsy: Beyond Seizures Control, the Experience of a Portuguese Pediatric Centre
Authors: Romão Luz Inês , Pereira Cristina , Garcia Paula , Ferreira Fátima , Faria Ana , Macedo Cristiane , Diogo Luísa , Robalo Conceição 
Published: December 2019

Introduction: Ketogenic diet is a low carbohydrate diet, which can be used as a treatment for refractory childhood epilepsy. The first aim of this study was to evaluate its efficacy, in patients receiving ketogenic diet for at least three months, on epilepsy control, behaviour and awareness. The secondary aims were to evaluate the variation in the number of antiepileptic drugs, reasons for discontinuing the diet and adverse effects.Material and Methods: Retrospective analysis of clinical records of patients who underwent ketogenic diet for refractory epilepsy, from October 2007 to January 2018, in a tertiary pediatric hospital.Results: In the twenty-nine eligible patients, the mean age of initiation was 7.9 years-old (+/– 5.6). Of those, 18 had a ≥ 50% reduction of seizure activity, 19 a marked behaviour improvement and 18 improved awareness. The median number of antiepileptic drugs remained equal for the 15 patients who completed 18 months of treatment (three drugs). The main reason for discontinuing ketogenic diet was a familiar decision. The main adverse effects were hypercholesterolemia (n = 23) and hypertriglyceridemia (n = 21).Discussion: Results were comparable to those of other cohorts, namely age of initiation, proportion of patients completing ketogenic diet, most frequent reasons for stopping and significant improvement of alertness and behavior.Conclusion: Beyond seizure control, patients experienced a marked improvement in behavior and awareness. It is necessary to develop strategies to increase the adherence of families to the diet.
Errata a “A Cirurgia de Substituição Valvular Aórtica Melhora a Qualidade de Vida dos Doentes?” Pedro COELHO, Lara N. FERREIRA, Clara VITAL, José FRAGATA. Acta Med Port 2018 Jul-Aug;31(7-8):399-408
Authors: Coelho Pedro , Ferreira Lara N. , Vital Clara , Fragata José 
Published: December 2019

Artigo publicado com erros: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/10241Na página 405, Tabela 3 onde se lê:A negrito o valor 34,4 na dimensão "limitação do Desempenho" referente à coluna "Seguimento a 6 meses"Deverá ler-se:A negrito o valor 37,9. Na página 406, Figura 4, onde se lê:O eixo do índice SF-6D com valores entre 0 a 50.Deverá ler-se:O eixo do índice SF-6D com valores entre 0 a 1.
Passive Transfer of Hepatitis B Antibodies through Intravenous Immunoglobulin in a Neonate
Authors: Rato João , Alves Daniela , Rodrigues Luís 
Published: December 2019

Passive transfer of antibodies secondary to intravenous immunoglobulin infusion is a rare but important side effect that can lead to the wrong diagnosis and therapeutic decisions. It has never been reported in a newborn. A male newborn, vaccinated against hepatitis B and diagnosed with dilated cardiomyopathy, presented positive hepatitis B core antibodies at 12 days of life. Exclusion of hepatitis B infection was mandatory as it would be a contraindication to heart transplant. Passive transfer of antibodies was confirmed at 44 days of age, after seroreversion of hepatitis B core antibodies. Passive transfer of antibodies after intravenous immunoglobulin infusion can lead to a misleading diagnosis if not recognized. In our patient it could have been especially harmful had it prevented heart transplant. Screening for hepatitis B should be performed at least 1 month after intravenous immunoglobulin infusion.
Formulasi Tablet Paracetamol dengan Bahan Pengikat Pati Umbi Gembili (Dioscorea esculenta L)
Authors: Zulfa Elya , Prihantini Malinda 
Published: December 2019

ABSTRAK Pati umbi gembili (PUG) memiliki kandungan utama amilopektin sebesar 75,7%. Amilopektin bersifat lekat dan dapat membentuk gel bila disuspensikan dengan air, sehingga dapat dimanfaatkan sebagai bahan pengikat. Tujuan penelitian ini adalah mengetahui sifat fisik tablet paracetamol dengan penambahan PUG sebagai bahan pengikat. Proses pembuatan pati dari umbi gembili dilakukan dengan cara basah. Tablet Parasetamol dibuat dengan metode granulasi basah dengan variasi kadar mucilago PUG FI 5%, FII 10%, FIII 15%. Tablet yang dibuat, diuji sifat fisik (keseragaman bobot, kekerasan, kerapuhan dan waktu hancur) dan dianalisis secara deskriptif. Hasil uji sifat fisik tablet menunjukkan bahwa seluruh formula yang dibuat memenuhi syarat yang ditetapkan dalam kompendial. Kata Kunci : Parasetamol, pati umbi gembili, bahan pengikat, granulasi basah ABSTRACT Gembili tuber (PUG) starch has a major component of amylopectin of 75.7%. Amylopectin is sticky and can form a gel when suspended with water, so that it can be used as a tablet binding agent in the form of PUG mucilago. The purpose of this study was to determine the physical characteristics in paracetamol tablets of adding PUG mucilago (Dioscorea esculenta) as a binder. The process of making starch from gembili tuber is done by wet. Paracetamol tablets are made by wet granulation method with variations in levels of FI PUG mucilago 5%, FII 10%, FIII15%. Tablets were made, tested for physical properties (weight uniformity, hardness, friability and disintegration time) with descriptive analysis. The test results of the physical properties of tablets indicate that all formulas made meet the requirements set out in the literature Keywords: Paracetamol, gembili tuber starch, binder, wet granulation
Efek Sitotoksik Ekstrak Etanolik Ocimum basilicum, L. Pada Sel Kanker Payudara
Authors: Hidayati Devi Nisa , Arifin Ibrahim , Zahroh Fatimatuz , Wahyuni Lina 
Published: December 2019

ABSTRAK Pengobatan kanker menggunakan bahan alam terus dikembangkan. Salah satu tanaman yang memiliki efek sitotoksik Ocimum basilicum, L. tujuan penelitian ini adalah mengetahui aktivitas sitotoksik dari ekstrak etanol Ocimum basilicum (EEOB) terhadap sel kanker payudara T47D dan MCF7. Ocimum basilicum diekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Pengujian aktivitas sitotoksik menggunakan metode MTT assay dengan seri konsentrasi EEOB 1000; 500; 250; 125; 62.5; 31,25 µg/mL. Hasil uji aktivitas sitotoksik EEOB memperlihatkan nilai IC50 pada sel T47D dan MCF-7 sebesar 399.86 µg/ml dan 387.76 µg/ml. Kata Kunci—Sitotoksik, Ocinum basilicum L., T47D, MCF-7 ABSTRACT Cancer treatment using natural ingredients continues to be developed. One of the plants that is proven to have cytotoxic activity is basil leaves (Ocimum basilicum, L.). This study aims to determine the cytotoxic activity of ethanol extract of basil leaves (EEBL) on T47D and MCF-7 breast cancer cells. Basil leaves were extracted using maceration with ethanol 70%. The cytotoxic test was perfomed using MTT assay with various EEBL concentrations: 1000; 500; 250; 125; 62.5; 31,25 µg/mL. The results showed that IC50 of cytotoxic activity in T47D and MCF-7 was 399.86 µg/ml and 387.76 µg/ml respectively. Keywords—Cytotoxic, Ocinum basilicum L., T47D, MCF-7
Gambaran Tingkat Pengetahuan Masyarakat Tentang Obat Generik di Kelurahan Keraton Kecamatan Martapura Kabupaten Banjar
Authors: Fitriah Rahmayanti , Mahriani Mahriani , Nurrahma Ika Maulida 
Published: December 2019

ABSTRAK Obat generik adalah obat yang penamaannya didasarkan pada kandungan zat aktif tertentu dalam suatu obat dan tidak menggunakan merk dagang. Persepsi pasien terhadap obat generik di masa penerapan JKN ini dinilai oleh banyak pengamat masih buruk, salah satunya yang menyatakan bahwa masih ada persepsi yang salah tentang obat generik, yaitu obat generik dianggap sebagai obat murah sehingga mutunya diragukan. Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan masyarakat terhadap obat generik di Kelurahan Keraton Kecamatan Martapura Kabupaten Banjar Kalimantan Selatan Indonesia. Penelitian ini merupakan penelitian deskriptif menggunakan desain cross sectional. Pengambilan data dilakukan melalui lembar kuesioner, dengan sampel yang dipilih menggunakan metode Stratified Random Sampling. Berdasarkan hasil penelitian yang dilakukan melalui uji kuesioner kepada 100 responden untuk menilai gambaran tingkat pengetahuan masyarakat tentang obat generik. Dari total sampel dijumpai bahwa 45 orang (45%) responden memiliki tingkat pengetahuan dengan katagori “sedang”. Kepada para pembuat kebijakan kesehatan diharapkan terus meningkatkan sosialisasi obat generik. Kepada pelayanan kesehatan, agar dapat meningkatkan kinerja dalam penyuluhan program promosi obat generik di daerah. Kata Kunci : Obat Generik, Masyarakat, Tingkat Pengetahuanl ABSTRACT Generic drugs are drugs that are named after the activecontained, and not using a trademark. The community’s perception of generic drugs during the JKN application was deemed unsavory by many observers, generic drugs are considered as cheap medicine with doubtable quality. This study aims to determine the level of public knowledge about generic drugs in Kelurahan Keraton Kecamatan Martapura Kabupaten Banjar South Borneo Indonesia. This research is a descriptive researchusing a cross sectional design. The data were collected through a questionnaire, with the sampled selection using Stratified Random Sampling method. Based on the results of the research conducted by the questioning 100 respondents to obtain the level of public knowledge about generic drugs. Of the total sample found, (45%) respondents (45%) has a knowledge level with the category "medium". To health policy makers to continue to increase the socialization of generic drugs. To health services, to improve education programs in the promotion of generic programs in the region. Keywords : Generic Drugs, Society, Level of Knowledge
Principally Quasi-Injective Semimodules
Authors: Et al. Aljebory 
Published: December 2019

In this work, the notion of principally quasi- injective semimodule is introduced, discussing the conditions needed to get properties and characterizations similar or related to the case in modules.
Let be an -semimodule with endomorphism semiring Ș. The semimodule is called principally quasi-injective, if every -homomorphism from any cyclic subsemimodule of to can be extended to an endomorphism of .
Does chemoradiotherapy benefit elderly patients with esophageal squamous cell cancer? A propensity-score matched analysis on multicenter data ( 3JECROG R-03A )
Authors: Chen Mingqiu , Liu Xiao hong , Han Chun , Wang Xin , Zhao Yidian , Pang Qingsong , Sun Xinchen , Li Gaofeng , Zhang Kaixian , Li Ling , Qiao Xueying , Lin Yu , Chen Junqiang , Xiao Zefen 
Published: December 2019

Abstract
Aim

The aim of the present study was to assess the efficacy of concurrent chemoradiotherapy (CRT) or radiotherapy alone (RT-alone) in elderly patients with esophageal squamous cell carcinoma (ESCC).

Methods

The clinical data of patients with ESCC treated with RT-alone or CRT were collected and retrospectively reviewed. The 1-, 3- and 5-year overall survival (OS) rates and the clinical characteristics correlated with survival were analyzed statistically. Propensity score matching (PSM) analyses were used to compensate for differences in baseline characteristics between the CRT and RT-alone groups to confirm the survival difference.

Results

A total of 729 patients fulfilling the inclusion criteria were reviewed. Diabetes, primary tumor volume (pTV), primary tumor location (pTLo), clinical T stage,(cT) clinical N stage (cN), clinical M stage (cM) and short-term response to RT were independent factors influencing OS (P=0.002-0.044). The 5-year OS rate was 26.6%, 26.0% and 30.1% in the whole cohort, RT-alone and CRT groups, respectively. The survival difference between RT alone and CRT was not significant before or following PSM. Compared with the corresponding subgroups treated with RT alone, CRT significantly benefited patients with diabetes (P=0.003), cT4 (P=0.030) and cN0 (P=0.049), whereas no benefit was identified between CRT and RT alone in the other subgroups, including cT1-3, cN1, cM, pTLo, pTV, age and gender.

Conclusions

CRT with the current chemotherapy regimens may not improve the survival of elderly ESCC patients compared to RT-alone, except in patients with cT4 stage, cN0 stage or diabetes. However, due to the limitation of the retrospective nature of the current study, further clinical trials are required for confirmation.

Key words: Concurrent chemoradiotherapy; Elderly; Esophageal squamous cell carcinoma; Survival
The grapevine homeobox gene VvHB58 influences seed and fruit development through multiple hormonal signaling pathways
Authors: Li Yunduan , Zhang Songlin , Dong Ruzhuang , Wang Li , Yao Jin , Nocker Steve van , Wang Xiping 
Published: December 2019

Abstract
Background: The homeobox transcription factor has a diversity of functions during plant growth and development process. Previous transcriptome analyses of seed development in grape hybrids suggested that specific homeodomain transcription factors are involved in seed development in seedless cultivars. However, the molecular mechanism of homeobox gene regulating seed development in grape is rarely reported.
Results: Here, we report that the grapevine VvHB58 gene, encoding a homeodomain-leucine zipper (HD-Zip I) transcription factor, participates in regulating fruit size and seed number. The VvHB58 gene was differentially expressed during seed development between seedless and seeded cultivars. Subcellular localization assays revealed that the VvHB58 protein was located in the nucleus. Transgenic expression of VvHB58 in tomato led to loss of apical dominance, a reduction in fruit pericarp expansion, reduced fruit size and seed number, and larger endosperm cells. Analysis of the cytosine methylation levels within the VvHB58 promoter indicated that the differential expression during seed development between seedless and seeded grapes may be caused by different transcriptional regulatory mechanisms rather than promoter DNA methylation. Measurements of five classic endogenous hormones and expression analysis of hormone-related genes between VvHB58 transgenic and nontransgenic control plants showed that expression of VvHB58 resulted in significant changes in auxin, gibberellin and ethylene signaling pathways. Additionally, several DNA methylation-related genes were expressed differentially during seed development stages in seedless and seeded grapes, suggesting changes in methylation levels during seed development may be associated with seed abortion.
Conclusion: VvHB58 has a potential function in regulating fruit and seed development by impacting multiple hormonal pathways. These results expand understanding of homeodomain transcription factors and potential regulatory mechanism of seed development in grapevine, and provided insights into molecular breeding for grapes.
Association of childhood socioeconomic status with edentulism among Chinese in mid-late adulthood
Authors: ZHANG XIAONING , CHEN SHUANG 
Published: December 2019

Abstract
Background: The aim of this study was to examine the association between childhood socioeconomic status (SES) and edentulism. Methods: The edentulous status of Chinese in mid-late adulthood was determined using self-reported lost all of teeth from the Health and Retirement Longitudinal Study (CHARLS). Childhood SES was determined based on the following parameters: the education, occupation and working status of the parents; financial situation of the family; relationship with the parents; care, love and affection from the mother; quarrels and fights between parents; primary residence; neighbors’ willingness to help and with close-knit relationships. Adulthood SES was assessed by educational achievements. This study used principal component analysis (PCA) to select variables and binary logistic regression models to determine the association between childhood SES and edentulism.Results: Data were available from a total of 17,713 respondents, 984 of whom were edentulous (2.9%). The prevalence of edentulism in mid- to late-age Chinese individuals was higher in those with poor childhood SES. In final regression model, edentulism was significantly associated with willingness of neighbors to help with close-knit relationships (OR = 0.89, 95% CI = 0.79 – 0.99), parents with high school education or above (OR = 1.18, 95% CI = 1.01 – 1.39) and drinking and smoking habits of the father (OR = 1.10, 95% CI = 0.97 – 1.24).Conclusion: Childhood SES was significantly associated with the prevalence of edentulism in mid- to late-age Chinese individuals. In particular, parents with high school education or above, unwillingness of neighbor to help with close-knit relationships, drinking and smoking habits of the father independent of adulthood SES were significantly associated with edentulism. Accordingly, the development of optimal recommendations and more effective intervention strategies requires considering the experiences in early life associated with poor SES contributes to poor oral health.
Pharmacodynamics of Pre-Operative PD1 Checkpoint Blockade and Receptor Activator of NFkB Ligand (RANKL) Inhibition in Non-Small Cell Lung Cancer (NSCLC): study protocol for a multicentre open-label phase 1B/2 translational trial (POPCORN)
Authors: Ahern Elizabeth Stephanie , Cubitt Annette , Ballard Emma , Teng Michele W. L. , Dougall William C. , Smyth Mark J. , Godbolt David , Naidoo Rishendran , Goldrick Amanda , Hughes Brett G. M. 
Published: December 2019

Abstract
Background Neoadjuvant immunotherapy targeting the immune checkpoint programmed death-1 (PD-1) is under investigation in various tumour settings including non-small-cell lung cancer (NSCLC). Preclinical models demonstrate the superior power of immunotherapy given in the neoadjuvant (pre-operative) compared with adjuvant (post-operative) setting to eradicate metastatic disease and induce long-lasting antigen-specific immunity. Novel effective immunotherapy combinations are widely sought in the oncology field, targeting non-redundant mechanisms of immune evasion. A promising combination partner with anti-PD1 in NSCLC is denosumab, a monoclonal antibody blocking Receptor Activator of NF-κB Ligand (RANKL). In preclinical cancer models, and a large retrospective case series in NSCLC, anti-cancer activity of combination immune checkpoint inhibition (ICI) and denosumab has been reported. Furthermore, clinical trials of ICI and denosumab are underway in advanced melanoma and clear-cell renal cell carcinoma. However, the mechanism of action of combination anti-PD1 and anti-RANKL is poorly defined. Methods This open-label multicentre trial will randomise by minimisation 30 patients with resectable stage IA (primary > 2cm) to IIIA NSCLC to a neoadjuvant treatment regime of either two doses of nivolumab (3 mg/kg every 2 weeks) or two doses of nivolumab (same regimen) plus denosumab (120 mg every 2 weeks, following nivolumab). Each treatment arm is of equal size, and be approximately balanced with respect to histology (squamous vs. non-squamous) and clinical stage (I-II vs IIIA). All patients will receive surgery for their tumour two weeks after the final dose of neoadjuvant therapy. The primary outcome will be translational research to define the tumour-immune correlates of combination therapy compared with monotherapy. Key secondary outcomes will include a comparison of rates of the following between each arm: toxicity, response (pathological and radiological), and microscopically complete resection. Discussion The POPCORN study provides a unique platform for translational research to determine the mechanism of action of a novel proposed combination immunotherapy for cancer. Trial registration Prospectively registered on Australian New Zealand Clinical Trials Registry (ACTRN12618001121257) on 06/07/2018.