bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of increasing land productivity on groundwater dynamics: a case study of an oasis located at the edge of the Gobi Desert
Authors: Lei Wu , Changbin Li , Xuhong Xie , Zhibin He , Wanrui Wang , Yuan Zhang , Jianmei Wei , Jianan Lv 
Published: May 2020

Abstract
Background
Intensification of agricultural systems may result in overexploitation of water resources in arid regions because enhanced productivity of crops is often associated with increased actual evapotranspiration (AET). The aim of this study was to quantify the effect of increased regional AET on the groundwater level in a case study of the oasis located within the Shiyang River Basin near the edge of the Gobi Desert.

Result
The results of the study show that regional AET increased during the period from 1981 to 2010 due to increasing oasis area and air temperature. The water losses due to AET exceeded the water supply from the mountainous discharges of the basin by the end of this period, leading to groundwater overexploitation in the oasis area.

Conclusions
This case study shows the importance of considering the effect of climate change on water losses associated with increasing agricultural production for the sustainable agricultural development of arid regions.
The differential expression of miRNAs between ovarian endometrioma and endometriosis-associated ovarian cancer
Authors: Nakamura Natsuho , Terai Yoshito , Nunode Misa , Kokunai Kana , Konishi Hiromi , Taga Sayaka , Nakamura Mayumi , Yoo Masae , Hayashi Masami , Yamashita Yoshiki , Ohmichi Masahide 
Published: May 2020

Abstract
Background
MicroRNAs (miRNAs) have been implicated to play a vital role in development, differentiation, cell proliferation and apoptosis. However, which miRNAs are actually associated with endometriosis-associated ovarian cancer remains controversial.

Methods
Serum and ascites samples were obtained from all patients. Serum samples from 5 cases of ovarian endometrioma and endometriosis-associated ovarian cancer each were submitted for comprehensive miRNA microarray profiling. We investigated the differential expression of miRNAs between the two groups to confirm the pivotal role of miRNAs. Quantitative reverse transcription-polymerase chain reaction validation of five selected miRNAs [miR-92a-3p, miR-486-5p, miR-4484, miR-6821-5p, and miR-7108-5p] was performed, and miR-486-5p expression analysis was followed by proliferation and wound healing assays, depending on the expression of miR-486-5p.

Result
miR-486-5p expression in serum and ascites samples from endometriosis-associated ovarian cancer patients was significantly higher than that from ovarian endometrioma patients. Moreover, the miR-486-5p level in serum and ascites samples was significantly correlated with the severity of the endometriosis. The upregulation of miR-486-5p in immortalized ovarian endometrioma cells significantly increased proliferation and migration. In contrast, the downregulation of miR-486-5p in these cells significantly decreased proliferation and migration.

Conclusion
miR-486-5p might function as an oncogenic miRNA in endometriosis-associated ovarian cancer and could be a noninvasive biomarker to prospect the severity of ovarian endometrioma.
Active surveillance of small renal masses
Authors: Sebastià Carmen , Corominas Daniel , Musquera Mireia , Paño Blanca , Ajami Tarek , Nicolau Carlos 
Published: May 2020

AbstractMost renal masses incidentally detected by cross-sectional images are benign, being mainly cysts, and if they are malignant, they are indolent in nature with limited metastatic potential. Enhanced renal masses less than 4 cm in size are known as small renal masses (SRMs), and their growth rate (GR) and the possibility of developing metastasis are extremely low. Delayed intervention of SRMs by closed and routine imaging follow-up known as active surveillance (AS) is now an option according to urological guidelines. Radiologists have a key position in AS management of SRMs even unifocal and multifocal (sporadic or associated with genetic syndromes) and also in the follow-up of complex renal cysts by Bosniak cyst classification system. Radiologists play a key role in the AS of both unifocal and multifocal (sporadic or associated with genetic syndromes) SRMs as well as in the follow-up of complex renal cysts using the Bosniak cyst classification system. Indeed, radiologists must determine which patients with SRMs or complex renal cysts can be included in AS, establish the follow-up radiological test algorithm to be used in different scenarios, perform measurements in follow-up tests, and decide when AS should be discontinued. The purpose of this article is to review the indications and management of AS in SRMs, especially focused on specific scenarios, such as complex renal cysts and multifocal renal tumors (sporadic or hereditary). In this work, the authors aimed to provide a thorough review of imaging in the context of active surveillance of renal masses.
Diagnostic stability in children and adolescents with bipolar disorder, a nationwide register-based study
Authors: Laursen Mathilde Frahm , Licht Rasmus W. , Correll Christoph U. , Kallehauge Tobias , Christensen Ann-Eva , Rodrigo-Domingo Maria , Nielsen René Ernst 
Published: May 2020

Abstract
Background
Diagnostic stability of bipolar disorder (BD) in children and adolescents, beyond the first contact has been investigated sparsely. The aim of this study was to investigate the diagnostic stability of BD in children and adolescents using over two decades of nationwide register-based data, and to examine factors associated with change from BD to schizophrenia (ICD-10: F20.x), schizoaffective disorder (ICD-10: F25.x) or other primary psychotic disorders (ICD-10 F23.x–24.x and F28.x–29.x).

Methods
Danish register-based data for all incident BD patients diagnosed prior to age 18 years, between January 1st 1995 and December 31st 2014 (N = 519). We graphically illustrated diagnostic change at different follow-up times and studied variables associated with diagnostic change after 3-year follow-up using Poisson regression with robust standard error estimates.

Results
The diagnosis of incident BD was relatively stable. The diagnosis did not change for 93% of those followed for at least 6 months, and remained unchanged for 86% and 73% of those followed at least 3 years and 10 years, respectively. In patients followed for at least 3 years after index BD (N = 478), the risk of diagnostic change was 61% higher in males versus females. The risk of diagnostic change for patients diagnosed during hospitalization was 74% higher compared to patients diagnosed at outpatient clinics/emergency rooms. The risk of diagnostic change for patients abusing substances other than alcohol and cannabis was 173% higher compared to patients not abusing such substances. The risk of diagnostic change for patients previously diagnosed with schizophrenia or related diagnosis was 257% higher compared to patients not having been diagnosed with such diagnosis previously, while the risk of diagnostic change in offspring of parents with schizophrenia or related diagnosis was 126% higher compared to patients who did not have parents diagnosed with such disorders.

Conclusion
Overall, the stability of the BD diagnosis in the Danish nationwide healthcare registers was high. Factors associated with risk of diagnostic change within 3 years of the initial diagnosis were being male, diagnosis given during hospitalization, substance abuse other than alcohol and cannabis, and a prior diagnosis of schizophrenia or related diagnosis in the patient or in their parents.
Personality traits, emotional intelligence and decision-making styles in Lebanese universities medical students
Authors: El Othman Radwan , El Othman Rola , Hallit Rabih , Obeid Sahar , Hallit Souheil 
Published: May 2020

Abstract
Background
This study aims to assess the impact of personality traits on emotional intelligence (EI) and decision-making among medical students in Lebanese Universities and to evaluate the potential mediating role-played by emotional intelligence between personality traits and decision-making styles in this population.

Methods
This cross-sectional study was conducted between June and December 2019 on 296 general medicine students.

Results
Higher extroversion was associated with lower rational decision-making style, whereas higher agreeableness and conscientiousness were significantly associated with a higher rational decision-making style. More extroversion and openness to experience were significantly associated with a higher intuitive style, whereas higher agreeableness and conscientiousness were significantly associated with lower intuitive style. More agreeableness and conscientiousness were significantly associated with a higher dependent decision-making style, whereas more openness to experience was significantly associated with less dependent decision-making style. More agreeableness, conscientiousness, and neuroticism were significantly associated with less spontaneous decision-making style. None of the personality traits was significantly associated with the avoidant decision-making style. Emotional intelligence seemed to fully mediate the association between conscientiousness and intuitive decision-making style by 38% and partially mediate the association between extroversion and openness to experience with intuitive decision-making style by 49.82 and 57.93% respectively.

Conclusion
Our study suggests an association between personality traits and decision-making styles. The results suggest that EI showed a significant positive effect on intuitive decision-making style and a negative effect on avoidant and dependent decision-making styles. Additionally, our study underlined the role of emotional intelligence as a mediator factor between personality traits (namely conscientiousness, openness, and extroversion) and decision-making styles.
Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA
Authors: Crouser Elliott D. , Parrillo Joseph E. , Martin Greg S. , Huang David T. , Hausfater Pierre , Grigorov Ilya , Careaga Diana , Osborn Tiffany , Hasan Mohamad , Tejidor Liliana 
Published: May 2020

Abstract
Background
The initial presentation of sepsis in the emergency department (ED) is difficult to distinguish from other acute illnesses based upon similar clinical presentations. A new blood parameter, a measurement of increased monocyte volume distribution width (MDW), may be used in combination with other clinical parameters to improve early sepsis detection. We sought to determine if MDW, when combined with other available clinical parameters at the time of ED presentation, improves the early detection of sepsis.

Methods
A retrospective analysis of prospectively collected clinical data available during the initial ED encounter of 2158 adult patients who were enrolled from emergency departments of three major academic centers, of which 385 fulfilled Sepsis-2 criteria, and 243 fulfilled Sepsis-3 criteria within 12 h of admission. Sepsis probabilities were determined based on MDW values, alone or in combination with components of systemic inflammatory response syndrome (SIRS) or quick sepsis-related organ failure assessment (qSOFA) score obtained during the initial patient presentation (i.e., within 2 h of ED admission).

Results
Abnormal MDW (> 20.0) consistently increased sepsis probability, and normal MDW consistently reduced sepsis probability when used in combination with SIRS criteria (tachycardia, tachypnea, abnormal white blood count, or body temperature) or qSOFA criteria (tachypnea, altered mental status, but not hypotension). Overall, and regardless of other SIRS or qSOFA variables, MDW > 20.0 (vs. MDW ≤ 20.0) at the time of the initial ED encounter was associated with an approximately 6-fold increase in the odds of Sepsis-2, and an approximately 4-fold increase in the odds of Sepsis-3.

Conclusions
MDW improves the early detection of sepsis during the initial ED encounter and is complementary to SIRS and qSOFA parameters that are currently used for this purpose. This study supports the incorporation of MDW with other readily available clinical parameters during the initial ED encounter for the early detection of sepsis.

Trial registration
ClinicalTrials.gov, NCT03145428. First posted May 9, 2017. The first subjects were enrolled June 19, 2017, and the study completion date was January 26, 2018.
Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner
Authors: Mackewn J. E. , Stirling J. , Jeljeli S. , Gould S-M. , Johnstone R. I. , Merida I. , Pike L. C. , McGinnity C. J. , Beck K. , Howes O. , Hammers A. , Marsden P. K. 
Published: May 2020

Abstract
Background
Despite the advent of clinical PET-MR imaging for routine use in 2011 and the development of several methods to address the problem of attenuation correction, some challenges remain. We have identified and investigated several issues that might affect the reliability and accuracy of current attenuation correction methods when these are implemented for clinical and research studies of the brain. These are (1) the accuracy of converting CT Hounsfield units, obtained from an independently acquired CT scan, to 511 keV linear attenuation coefficients; (2) the effect of padding used in the MR head coil; (3) the presence of close-packed hair; (4) the effect of headphones. For each of these, we have examined the effect on reconstructed PET images and evaluated practical mitigating measures.

Results
Our major findings were (1) for both Siemens and GE PET-MR systems, CT data from either a Siemens or a GE PET-CT scanner may be used, provided the conversion to 511 keV μ-map is performed by the PET-MR vendor’s own method, as implemented on their PET-CT scanner; (2) the effect of the head coil pads is minimal; (3) the effect of dense hair in the field of view is marked (> 10% error in reconstructed PET images); and (4) using headphones and not including them in the attenuation map causes significant errors in reconstructed PET images, but the risk of scanning without them may be acceptable following sound level measurements.

Conclusions
It is important that the limitations of attenuation correction in PET-MR are considered when designing research and clinical PET-MR protocols in order to enable accurate quantification of brain PET scans. Whilst the effect of pads is not significant, dense hair, the use of headphones and the use of an independently acquired CT-scan can all lead to non-negligible effects on PET quantification. Although seemingly trivial, these effects add complications to setting up protocols for clinical and research PET-MR studies that do not occur with PET-CT. In the absence of more sophisticated PET-MR brain attenuation correction, the effect of all of the issues above can be minimised if the pragmatic approaches presented in this work are followed.
A critical review speculating on the protective efficacies of autogenous Streptococcus suis bacterins as used in Europe
Authors: Rieckmann Karoline , Pendzialek Sophia-Mareike , Vahlenkamp Thomas , Baums Christoph G. 
Published: May 2020

Abstract
Background
Streptococcus (S.) suis is a major porcine pathogen causing high morbidity worldwide. This includes well-managed herds with high hygiene standards. In Europe, no licensed vaccine is available. As practitioners are obliged to reduce the use of antibiotics, autogenous S. suis vaccines have become very popular in Europe.

Main body
Autogenous vaccines (AV) are generally neither tested for safety, immunogenicity nor protective efficacy, which leads to substantial uncertainties regarding control of disease and return on investment. Here, S. suis publications are reviewed that include important data on epidemiology, pathologies and bacterin vaccination relevant for the use of AV in the field. Differences between herds such as the porcine reproductive and respiratory syndrome virus infection status and the impact of specific S. suis pathotypes are probably highly relevant for the outcome of immunoprophylaxis using autogenous S. suis bacterins. Thus, a profound diagnosis of the herd status is crucial for management of expectations and successful implementation of AV as a tool to control S. suis disease. Induction of opsonizing antibodies is an in vitro correlate of protective immunity elicited by S. suis bacterins. However, opsonophagocytosis assays are difficult to include in the portfolio of diagnostic services.

Conclusion
Autogenous S. suis bacterins are associated with limitations and risks of failure, which can partly be managed through improvement of diagnostics.
An update on eating disorders
Authors: Morris Jane , Anderson Stephen 
Published: May 2020

SUMMARYEating disorders are heterogeneous disorders characterised by a maladaptive drive to lose weight and, for the most part, by extreme fear of weight gain and overvaluation of thin body image. Calorie restriction, overexercise and purging behaviours put some sufferers at high risk of physical morbidity and mortality. Mental preoccupations interfere with social, professional and general quality of life. Patients’ defensive secrecy and compulsivity can make it hard to diagnose and treat such disorders despite the suffering they involve. Integrated medical and psychiatric intervention can save life and safely improve nutrition. Behavioural support – with family and carer involvement when appropriate – can counter the dysregulation that leads to vicious cycles of restriction–binge–purge, helping patients develop new skills to regulate emotion without weight losing. In the future, exciting developments in neuroimaging, neurosurgery and pharmacology may lead to ways to make the brain more responsive to therapy. Insights into risk factors may also improve preventive strategies in a climate of highly sophisticated international electronic communication.
Suggested Curricular Guidelines for Musculoskeletal and Sports Medicine in Family Medicine Residency Training
Authors: Brennan Fred H. , Rao Ashwin L. , Myers Rebecca A. , Ferderber Megan , Marcussen Britt , Mansfield Linda , Miller Emily M. , Spittler Jack , Sylvester Jillian 
Published: May 2020

AbstractPatients often seek care from a family physician when they have a musculoskeletal injury or sport-related ailment. Family physicians must be adequately trained to provide this care. While general guidance is provided by the Accreditation Counsel for Graduate Medical Education (ACGME) it is left up to the individual programs to develop, implement, and execute their orthopedic and sports medicine curriculums. The American Academy of Family Physicians' (AAFP) Recommended Curriculum Guideline for Family Medicine Residents — Musculoskeletal and Sports Medicine provides a basic outline format for curriculum content and reference resources. The aim of this article is to elaborate on those training requirements and help programs to develop a curriculum implementation plan that will deliver a baseline level of competence for family medicine trainees.
Patient-centered benefit-risk analysis of transcatheter aortic valve replacement
Authors: Marsh Kevin , Hawken Natalia , Brookes Ella , Kuehn Carrie , Liden Barry 
Published: May 2020

Background: Aortic stenosis (AS) treatments include surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). Choosing between SAVR and TAVR requires patients to trade-off benefits and risks. The objective of this research was to determine which TAVR and SAVR outcomes patients consider important, collect quantitative data about how patients weigh benefits and risks, and evaluate patients’ preferences for SAVR or TAVR. Methods: Patients were recruited from advocacy organization databases. Patients self-reported as being diagnosed with AS, and as either having received AS treatment or as experiencing AS-related physical activity limitations. An online adapted swing weighting (ASW) method – a pairwise comparison of attributes – was used to elicit attribute tradeoffs from 219 patients. Survey data were used to estimate patients’ weights for AS treatment attributes, which were incorporated into a quantitative benefit-risk analysis (BRA) to evaluate patients’ preferences for TAVR and SAVR. Results: On average, patients put greater value on attributes that favored TAVR than SAVR. Patients’ valuation of the lower mortality rate, reduced procedural invasiveness, and quicker time to return to normal quality of life associated with TAVR, offset their valuation of the time over which SAVR has been proven to work. There was substantial heterogeneity in patients’ preferences. This was partly explained by age, with differences in preference observed between patients <60 years to those ≥60 years. A Monte Carlo Simulation found that 79.5% of patients prefer TAVR. Conclusions: Most AS patients are willing to tolerate sizable increases in clinical risk in exchange for the benefits of TAVR, resulting in a large proportion of patients preferring TAVR to SAVR. Further work should be undertaken to characterize the heterogeneity in preferences for AS treatment attributes. Shared decision-making tools based on attributes important to patients can support patients’ selection of the procedure that best meets their needs.
Patients with Chemical Dependence: Sociodemographic and Clinical Profile
Authors: Martins Fabiana Gonçalves Pinheiro , Veras Helenicy Nogueira Holanda , Coelho José Leonardo Gomes , Malta Júnior Alberto , Saraiva Emanuela Machado Silva , Santana Willma José de , Rangel Francisca Eritânia Passos 
Published: May 2020

The study aimed to delineate the clinical and sociodemographic profile of patients treated at the Psychosocial Care Center Alcohol and other Drugs. This is a descriptive, documentary, retrospective and exploratory research conducted in the city of Crato-CE, based on CAPS AD, and using as a data collection instrument a table containing information necessary for the study of 60 patient records. It was observed that the majority of patients were men (70%), single (47%), incomplete elementary school (42%), unemployed (66%) and low income (45%). The association of alcohol and cigarettes (50%) was the most common and the most used drugs were antidepressants (69%) and antipsychotics (17%). It was concluded that the performance of professionals is extremely relevant in the treatment of chemical dependence reducing the recurrence of patients. Keywords: Mental health. Medical records. Psychopharmaceuticals.