bluuebunny/crossref_metadata_2025_split huggingface dataset:
FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1
Authors: Chen Rui , Li Deyu , Zheng Meng , Chen Bin , Wei Ting , Wang Yu , Li Man , Huang Weimei , Tong Qin , Wang Qi , Zhu Yaru , Fang Wei , Guo Linlang , Fang Shun 
Published: January 2020

AbstractFibroblast growth factor receptor‐like 1 (FGFRL1), a member of the FGFR family, has been demonstrated to play important roles in various cancers. However, the role of FGFRL1 in small‐cell lung cancer (SCLC) remains unclear. Our study aimed to investigate the role of FGFRL1 in chemoresistance of SCLC and elucidate the possible molecular mechanism. We found that FGFRL1 levels are significantly up‐regulated in multidrug‐resistant SCLC cells (H69AR and H446DDP) compared with the sensitive parental cells (H69 and H446). In addition, clinical samples showed that FGFRL1 was overexpressed in SCLC tissues, and high FGFRL1 expression was associated with the clinical stage, chemotherapy response and survival time of SCLC patients. Knockdown of FGFRL1 in chemoresistant SCLC cells increased chemosensitivity by increasing cell apoptosis and cell cycle arrest, whereas overexpression of FGFRL1 in chemosensitive SCLC cells produced the opposite results. Mechanistic investigations showed that FGFRL1 interacts with ENO1, and FGFRL1 was found to regulate the expression of ENO1 and its downstream signalling pathway (the PI3K/Akt pathway) in SCLC cells. In brief, our study demonstrated that FGFRL1 modulates chemoresistance of SCLC by regulating the ENO1‐PI3K/Akt pathway. FGFRL1 may be a predictor and a potential therapeutic target for chemoresistance in SCLC.
Catechin relieves hypoxia/reoxygenation‐induced myocardial cell apoptosis via down‐regulating lncRNA MIAT
Authors: Cong Lin , Su Yisheng , Wei Dazhen , Qian Lu , Xing Dawei , Pan Jialin , Chen Ye , Huang Mingyuan 
Published: January 2020

AbstractBackgroundCatechin protects heart from myocardial ischaemia/reperfusion (MI/R) injury. However, whether catechin inhibits H/R‐induced myocardial cell apoptosis is largely unknown.ObjectiveThis study aims to investigate the underlying mechanism of catechin in inhibiting the apoptosis of H/R‐induced myocardial cells.MethodsLncRNA MIAT expression was detected by qRT‐PCR. Cell viability of H9C2 cells was detected using CCK‐8 assay. The apoptosis of H9C2 cells was detected by flow cytometry. The interaction between CREB and MIAT promoter regions was confirmed by dual‐luciferase reporter gene assay and ChIP assay.ResultsIn MI/R rats, catechin improved heart function and down‐regulated lncRNA MIAT expression in myocardial tissue. In H/R‐induced H9C2 cells, catechin protected against cell apoptosis, and lncRNA MIAT overexpression attenuated this protective effect of catechin. We confirmed that transcription factor CREB could bind to MIAT promoter region, and catechin suppressed lncRNA MIAT expression through up‐regulating CREB. Catechin improved mitochondrial function and relieved apoptosis through promoting Akt/Gsk‐3β activation. In addition, MIAT inhibited Akt/Gsk‐3β activation and promoted cell apoptosis in H/R‐induced H9C2 cells. Finally, we found catechin promoted Akt/Gsk‐3β activation through inhibiting MIAT expression in H/R‐induced H9C2 cells.ConclusionCatechin relieved H/R‐induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk‐3β pathway.
Levels of smoking and dental implants failure: A systematic review and meta‐analysis
Authors: Naseri Roohollah , Yaghini Jaber , Feizi Awat 
Published: January 2020

AbstractAimThe present systematic review and meta‐analysis was performed to investigate if there was a significantly enhanced risk of dental implant failure due to the increased number of cigarettes smoked per day.Materials and MethodsFour databases, including PubMed, Embase, Web of Science and Scopus, were searched until January, 2019. The search terms “dental implant, oral implant, smoking, smoker, tobacco, nicotine and non‐smoker” were used in combination to identify the publications providing data for dental implant failures related to the smoking habit. Publications were excluded if the quantity of cigarettes consumed per day was not reported. Fixed‐ or random‐effects meta‐analyses were used to pool the estimates of relative risk (RR) with 95% confidence intervals (CI).ResultsHaving additional information supplied by the authors, 23 articles were selected for final analysis. The meta‐analyses based on implant‐ and patient‐related data showed a significant increase in the RR of implant failure in patients who smoked >20 cigarettes per day compared with non‐smokers (implant based:p = .001; RR: 2.45; CI: 1.42–4.22 and patient based:p < .001; RR: 4; CI: 2.72–5.89).ConclusionThe risk of implant failure was elevated with an increase in the number of cigarettes smoked per day.
Identification of factors associated with minimal erythema dose variations in a large‐scale population study of 22 146 subjects
Authors: Tan Y. , Wang F. , Fan G. , Zheng Y. , Li B. , Li N. , Liu Y. , Wang X. , Liu W. , Krutmann J. , Zou Y. , Wang S. 
Published: January 2020

AbstractBackgroundMinimal erythema dose (MED) has substantial inter‐ and intraindividual variations, reflecting the influence of very diverse factors. However, related studies showed little consistency probably because of their limited sample size.ObjectiveTo identify the factors associated with MED variations in a large‐scale population study.MethodsThe MED test was performed by following the international standard procedure on 22 146 subjects. The results were analysed in adjusted multivariable linear and logistic regression models.ResultsThis large‐scale study revealed that lower MED was consistently associated with lighter skin [β‐coefficient = −0.33, 95% confidence interval (CI) −0.36 to 0.30, P = 6.41 × 10−84]. Females had significantly higher MED than male (β = 0.91, 0.32–1.50, P = 2.93 × 10−3). Stratified analyses showed that MED was not associated with age [female: odds ratio (OR) = 0.99, 0.98–1.01; male: OR = 0.99, 0.97–1.00]. MED was lower in summer than in other seasons (spring: OR = 1.08, 1.06–1.11; autumn: OR = 1.11, 1.08–1.13; winter: OR = 1.20, 1.18–1.22). Furthermore, MED was associated with air temperature (β = −0.36, −0.49 to 0.23, P = 4.81 × 10−8) and air pressure (β = −0.64, −0.82 to 0.46, P = 8.01 × 10−12) in summer only while not in other seasons.ConclusionsThis study provides unprecedented evidence that MED is associated with skin colour, sex, season and meteorological factors, but not with age.
Minimizing the dermatoscopic morphologic overlap between basal and squamous cell carcinoma: a retrospective analysis of initially misclassified tumours
Authors: Neagu N. , Lallas K. , Maskalane J. , Salijuma E. , Papageorgiou C. , Gkentsidi T. , Spyridis I. , Morariu S.‐H. , Apalla Z. , Lallas A. 
Published: January 2020

AbstractBackgroundBasal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have well‐established dermatoscopic criteria that make them relatively easy to recognize on a clinical basis. However, even with the addition of dermatoscopy, a morphologic overlap between the two tumours does exist.ObjectivesTo analyse the dermatoscopic morphology of clinically and dermatoscopically misclassified BCCs and SCCs, to identify factors causing the erroneous clinical interpretation and, therefore, minimize the morphologic overlap between BCC and SCC.MethodsRetrospective study including histopathologically diagnosed BCCs or SCCs that had been clinically inversely diagnosed. Their dermatoscopic images were blindly evaluated for the presence of predefined criteria. Descriptive statistics were performed and univariate and multivariate predictors were calculated.ResultsA total of 68 cases were included, 41 of which were BCCs and 27 SCCs. Most tumours in both groups were non‐pigmented, ulcerated and displayed a polymorphous vascular pattern. The presence of erosions was positively associated to BCC (5.2‐fold higher odds, P = 0.05), whereas scales/keratin masses were positively associated to SCC (3.7‐fold higher odds, P = 0.07), although marginally not statistically significant.ConclusionsClinically misclassified BCCs and SCCs are usually non‐pigmented ulcerated tumours. Erosions and keratin masses/scales are more robust criteria as compared to vascular structures for the differential diagnosis between BCC and SCC.
Daylight photodynamic therapy with methyl aminolevulinate cream is as effective as conventional photodynamic therapy with blue light in the treatment of actinic keratosis: a controlled randomized intra‐individual study
Authors: Assikar S. , Labrunie A. , Kerob D. , Couraud A. , Bédane C. 
Published: January 2020

AbstractBackgroundWe know the efficacy of daylight phototherapy dynamic (DL‐PDT) in the treatment of actinic keratosis (AK). But the almost studies have compared daylight with red light using methyl aminolevulinate cream and not with blue light. PDT with blue light is another conventional PDT that is effective in the treatment of AKs.ObjectivesThe aim of this study is to assess the efficacy and the safety of DL‐PDT vs. PDT in blue light in the treatment of AKs.MethodsThis randomized, controlled, intra‐individual efficacy and safety study enrolled 26 subjects. AKs on the face/scalp were treated once, with DL‐PDT on one side and c‐PDT on the contralateral side. Primary endpoints for DL‐PDT at week 12 were efficacy with clearance of AKs and safety with assessment of pain. Lesions with complete response 12 weeks after one treatment session were followed until week 24.ResultsMore than 1000 AK were studied. At week 12, the raw number of disappeared AK lesions at 3‐month follow‐up was 19.6 (±6.0) for DL‐PDT and 20.0 (±6.9) for c‐PDT with P = 0.8460 (90.5% vs. 94.2% of AK disappearance, respectively). The response was maintained at 6 months (90.0% and 94.6% of AK reduction, respectively). DL‐PDT was nearly painless than c‐PDT with light blue: 1.2 vs. 5.1, respectively (P < 0.0001).ConclusionsDaylight‐PDT seems as effective as c‐PDT with light blue and DL‐PDT is less painful. The response of DL‐PDT was sustainable until 6 months.
Reticulohistiocytoses: a revision of the full spectrum
Authors: Bonometti A. , Berti E. ,   for Associazione Italiana Ricerca Istiocitosi ONLUS
Published: January 2020

AbstractReticulohistiocytoses (RH) are rare and clinically heterogeneous histiocytic disorders of dermatological interest. Three clinical entities with superimposable histopathological features are currently considered, namely solitary reticulohistiocytoma, diffuse/generalized reticulohistiocytosis and multicentric reticulohistiocytosis. Although in the last decade, RH studies have only minimally progressed, histiocytosis research has advanced considerably: the prognostic and therapeutic importance of the clinical subclassification of histiocytosis patients as well as of the detection of genetic alterations in the genes of the ERK pathway has been highlighted. According to these insights, we previously reported the presence of molecular alteration RH and described a subset of patients with disseminated multisystem involvement lacking arthritis. In the present review, we aim to update and revise the knowledge regarding RH. We first reviewed their histopathological, immunophenotypical and ultrastructural features, discussed their histopathological differential diagnosis with other conditions characterized by infiltrates made of oncocytic or epithelioid cells (with special regard to Destombes–Rosai–Dorfman disease) and finally summarized the molecular landscape of RH. We therefore tried to adjust the clinical subclassification of Langerhans cell histiocytosis to the clinical phenotypes of RH, outlining five clinically different groups of patients. Finally, we reconsidered the clinical workflow to the evaluation of RH patients, in light of the 5 different clinical groups and discussed the different therapeutic approaches and the possible role of target inhibitors.
Clinical diversity and treatment approaches to blastic plasmacytoid dendritic cell neoplasm: a retrospective multicentre study
Authors: Brüggen M.‐C. , Valencak J. , Stranzenbach R. , Li N. , Stadler R. , Jonak C. , Bauer W. , Porkert S. , Blaschke A. , Meiss F. , Nicolay J. P. , Wehkamp U. , Schlaak M. , Nguyen V.A. , Romani N. , Cozzio A. , Gayathri N. , Dimitriou F. , French L. E. , Dummer R. , Guenova E. 
Published: January 2020

AbstractBackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive type of haematologic precursor malignancy primarily often manifesting in the skin. We sought to provide a thorough clinical characterization and report our experience on therapeutic approaches to BPDCN.MethodsIn the present multicentric retrospective study, we collected all BPDCN cases occurring between 05/1999 and 03/2018 in 10 secondary care centres of the German–Swiss–Austrian cutaneous lymphoma working group.ResultsA total of 37 BPDCN cases were identified and included. Almost 90% of the patients had systemic manifestations (bone marrow, lymph nodes, peripheral blood) in addition to skin involvement. The latter presented with various types of cutaneous lesions: nodular (in more than 2/3) and bruise‐like (in 1/3) skin lesions, but also maculopapular exanthema (in circa 1/6). Therapeutically, 22 patients received diverse combinations of chemotherapeutic regimens and/or radiotherapy. Despite initial responses, all of them ultimately relapsed and died from progressive disease. Eleven patients underwent haematopoietic stem cell transplantation (HSCT; autologous HSCT n = 3, allo‐HSCT n = 8). The mortality rate among HSCT patients was only 33.33% with a median survival time of 60.5 months.ConclusionOur study demonstrates the clinical diversity of cutaneous BPDCN manifestations and the positive development observed after the introduction of HSCT.
The diagnostic value of fetal fibronectin testing in clinical practice
Authors: Cornelissen Lisa G. H. , van Oostrum Noortje H. M. , van der Woude Daisy A. A. , Rolf Christel , Porath Martina M. , Oei S. Guid , van Laar Judith O. E. H. 
Published: January 2020

AbstractAimTo evaluate the clinical management to withhold treatment for preterm labor in symptomatic women with an intermediate cervical length and negative fetal fibronectin (fFN) testing.MethodsA retrospective cohort study was performed in a tertiary care teaching hospital in the Netherlands. Pregnant women with a gestational age between 23+5 to 34+0 weeks, with the presence of regular uterine contractions accompanied by a cervical length between 15 and 30 mm and intact membranes, who underwent fFN testing were included to obtain the diagnostic value of fFN testing for preterm delivery within 7 days.ResultsFetal fibronectin testing has an extremely high negative predictive value (100%) and sensitivity (100%) for delivery within 7 days, in singleton and multiple pregnancies. However, specificity (64%) and positive predictive value (10%) of fFN testing in singleton pregnancies are low. Blood present on the fFN sample does not affect the reliability of the fFN test; the negative predictive value remains 100%.ConclusionWomen with symptoms of early preterm labor, intact membranes, a cervical length between 15 and 30 mm and negative fFN testing do not deliver within 7 days. Administration of corticosteroids and tocolytics can safely be withhold. Furthermore, blood on the fFN sample does not change the reliability of the fFN test.
Decline number of uterine fundal pressure maneuver in Japan recent 5 years
Authors: Hasegawa Junichi , Sekizawa Akihiko , Arakaki Tatsuya , Ikeda Tomoaki , Ishiwata Isamu , Kinoshita Katsuyuki ,   On behalf of Japan Association of Obstetricians and Gynecologists (JAOG), Tokyo, Japan
Published: January 2020

AbstractAimTo clarify whether the incidence of uterine fundal pressure (UFP) maneuver at delivery and consequent uterine rupture were declined.MethodsPopulation‐based postal questionnaire study was conducted. A questionnaire was sent to obstetric institutions across Japan. Questions were included the total number of deliveries, UFP and uterine ruptures associated with UFP in 2012 and 2017. As the primary outcome, frequencies of the UFP and uterine rupture were compared between 2012 and 2017. The secondary outcomes were included improved managements of delivery regarding UFP.ResultsA number of vaginal deliveries were significantly declined from 80.4% in 2012 to 78.1% in 2017 (P < 0.001). Frequencies of UFP per vaginal deliveries were also significantly declined 11.2% (38 973/347771) in 2012 to 9.5% (35 205/404444) in 2017 (<0.001). Number of uterine ruptures were 6 cases in 2012 (1:6496) and 11 cases in 2017 (1:3473) (P = 0.210). Compared to situation in 2012, informed consent was more frequently obtained for UFP in 2017. Written informed consent for UFP became to be obtained in 12% of institutions in 2017 from only 3% in 2012. More than 80% of institutions are performing UFP within 3 times. Regarding to uterine rupture, try of labor after the cesarean section, UFP and augmentation were improved in more than 10% of institutions. Most impact vehicle changing behavior was OBGY clinical guideline.ConclusionAlthough significant declined incidence of uterine rupture after UFP could not be demonstrated, frequency of UFP was decreased recent 5 years. This is due to improvement of obstetric management by obstetric caregivers throughout Japan.
Fetal cloacal dysgenesis sequence presented with first trimester megacystis and associated umbilical cord abnormalities
Authors: Gursoy Erzincan Selen , Sayin N. Cenk , Inan Cihan , Uzun Isil , Yapici Ugurlar Ozge , Varol Fusun G. 
Published: January 2020

AbstractCloacal dysgenesis sequence occurs as a result of complete developmental failure of the urorectal septum. Typically, the sequence is featured by a smooth perineum, without any urethral, genital or anal openings. Its clinical manifestation differs throughout gestation. We report an interesting case of first trimester megacystis with associated umbilical cord abnormalities in a female fetus having cloacal dysgenesis sequence. This rare association reflecting high urinary pressure should first suggest urethral atresia. Our case highlights the importance of routine inspection of umbilical cord in the workup of early megacystis in terms of both etiology and fetal diagnosis.
Accuracy and bias in first impressions of attachment style from faces
Authors: Alaei Ravin , Lévêque Germain , MacDonald Geoff , Rule Nicholas O. 
Published: January 2020

AbstractObjectivePeople gather important social information from subtle nonverbal cues. Given that one's attachment style can meaningfully affect the quality of one's relationships, we investigated whether people could perceive men's and women's attachment styles from photos of their neutral faces.MethodIn two studies, we measured targets' attachment styles then asked participants (total N = 893) to judge the male and female targets' attachment anxiety and avoidance from photos of their neutral faces (total N = 331) and to report their own attachment anxiety and avoidance.ResultsParticipants detected men's attachment style from face photos significantly better than chance in an initial exploratory study and in a preregistered replication but did not consistently detect women's attachment style from their face photos. Moreover, participants' own attachment style biased these first impressions: Individuals with greater attachment anxiety viewed others as more anxiously attached.ConclusionsPeople can detect some hints of unacquainted others' attachment styles from their faces but their own anxious attachment can bias these judgments.
Clustering of instrumental methods to characterize the texture and the rheology of slimy okra (Abelmoschus esculentus) suspensions
Authors: Savouré Timoty , Dornier Manuel , Vachoud Laurent , Collignan Antoine 
Published: January 2020

AbstractOkra (Abelmoschus esculentus) is one of the ingredients widely used in African gastronomy because of the unique slimy texture it gives to sauces. However, processing and formulation can affect the textural and rheological properties of these sauces, leading to unacceptable quality for the African consumer. The aim of this study was to select the instrumental measurements best enabling (a) characterization of the rheology and texture of slimy sauces prepared from okra and (b) monitoring its evolution during the preservation process. Thirty‐seven slimy suspensions (sauces and purées) were measured with 16 rheological and textural parameters. A principal component analysis revealed that flow consistency index K and flow behavior index n were well correlated with visco‐elastic, adhesive, and shear thinning properties, and that stringiness was well correlated with elongational, cohesive, and ductile properties. These two sets of measurement methods are sufficient to characterize their rheological and textural properties, and necessary to discriminate them according to their process and formulation.
Applying sensory and instrumental techniques to evaluate the texture of French fries from fast food restaurant
Authors: Li Peiyan , Wu Gangcheng , Yang Dan , Zhang Hui , Qi Xiguang , Jin QingZhe , Wang Xingguo 
Published: January 2020

AbstractThe aim of the work is to explore the relationship between the instrument and sensory data and to select the type of probes suitable for determining the texture of French fries. Ten commercial French fries were assessed using different probe types and perceived sensations through descriptive analysis. The eight sensory attributes developed by trained panelists can distinguish samples well. Simultaneously, the result of instrument data analysis revealed that the variation coefficient of three‐point bending was the largest, which indicates that the measurement accuracy was lower. The compression test showed significant correlation with most of the sensory attributes (r = .64–.90), while the cut test with a Volodkevich Bite Jaws probe does not correlate with all sensory attributes (r = .03–.49). Among these instrumental methods, compression, blade with guillotine probe, and puncture test are recommended for texture measuring of French fries. These results will provide a time‐saving and efficient method for determining the texture of French fries.