bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing Two-Year Apprenticeships in Norway and Switzerland
Authors: Schmid Evi , Scharnhorst Ursula , Kammermann Marlise 
Published: July 2020

AbstractOver the last 15 years, different countries have developed low-level vocational education and training (VET) programmes for young people who struggle to enter or complete education at upper secondary level. Switzerland introduced nationally standardised two-year initial VET programmes in 2005, Norway in 2016. Data of interviews with curriculum experts in Norway and Switzerland provided an empirical basis to examine the underlying intentions for offering these programmes and the respective criteria for defining the learning outcomes and the curricula. The reference frame in Norway for identifying appropriate learning outcomes and selecting learning goals are the national curricula of the respective four-year VET programmes. In Switzerland, the learning outcomes of two-year curricula are defined by lower-level occupational activities which are usually identified in analyses involving active workers and experts in the respective fields. Despite these differences, the criteria for developing two-year curricula are largely the same in both countries. The findings further show that two-year VET programmes in Norway are not intended to lead to a direct labour market entry but are understood as a first step of a staged qualification whereas in Switzerland they are designed to find a viable balance between employability and permeability to the more demanding three- or four-year VET programmes. In both countries, the two-year apprenticeships do not correspond to a holistic concept of vocation.
Chinese control over African and global mining—past, present and future
Authors: Ericsson Magnus , Löf Olof , Löf Anton 
Published: July 2020

AbstractChinese companies are far from taking control over African or global mining. In 2018, they control less than 7% of the value of total African mine production. Chinese investments in African mining of non-fuel minerals between 1995 and 2018 have contributed to production growth but it has also increased Chinese control over African mineral and metal production. There is evidence pointing to a continued Chinese expansion in African minerals and metals but at a slower pace than in the past decade. Through a detailed analysis of every mine, fully or partially controlled by Chinese interest in Africa and all other parts of the world the paper also measures total Chinese control over global mine production to be around 3% of the total value.
ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer
Authors: Liu Yang , Qin Peng , Wu Rong , Du Lianfang , Li Fan 
Published: July 2020

AbstractPancreatic cancer is the fourth most common lethal malignancy with an overall 5-year survival rate of less than 5%. ERas, a novel Ras family member, was first identified in murine embryonic stem cells and is upregulated in various cancers. However, the expression and potential role of ERas in pancreatic cancer have not been investigated. In this study, we found that ERas mRNA and protein were upregulated in pancreatic cancer tissues and cells compared with controls. Knockdown of ERas in pancreatic cancer cells by siRNA significantly decreased cell proliferation, colony formation, migration, and invasion and promoted cell apoptosis in vitro. Epithelial–mesenchymal transition (EMT) is closely related to tumor progression. We observed a significant decrease in N-cadherin expression in pancreatic cancer cells in response to ERas gene silencing by immunofluorescence assay and western blot. Furthermore, tumor growth and EMT were inhibited in xenografts derived from pancreatic cancer cells with ERas downregulation. We further investigated the regulatory mechanisms of ERas in pancreatic cancer and found that ERas may activate the Erk/Akt signaling pathway. Moreover, Erk inhibitor decreased pancreatic cancer cells proliferation and colony formation activities. Our data suggest that targeting ERas and its relevant signaling pathways might represent a novel therapeutic approach for the treatment of pancreatic cancer.
Evaluation of the risk of acute kidney injury with the use of piperacillin/tazobactam among adult critically ill patients
Authors: Saad Mohamed O. , Mohamed Adham M. , Mitwally Hassan A. , Shible Ahmed A. , Ait Hssain Ali , Abdelaty Mohamed A. 
Published: July 2020

AbstractPurposePiperacillin/tazobactam (PT), when combined with vancomycin, is associated with an increased risk of acute kidney injury (AKI). It is not known whether PT alone is associated with a higher incidence of AKI compared to other β-lactams among critically ill patients. The objective of this study was to compare the incidence of AKI associated with the use of PT to other β-lactams among adult critically ill patientsMethodsThis retrospective study was conducted in the surgical and the medical intensive care units at two hospitals within Hamad Medical Corporation (HMC) in Qatar and included adult critically ill patients who received at least one dose of anti-pseudomonal β-lactams. The primary outcome was acute kidney injury, defined using the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Multiple logistic regression with adjustment for pre-specified potential confounders was used for the primary outcome analysis.ResultsA total of 669 patients were included in the analysis: 507 patients in the PT group and 162 patients in the control (meropenem/cefepime) group. AKI occurred in 136 (26.8%) members of the PT group and 38 (23.5%) members of the control group [odds ratio (OR) 1.2; 95% confidence interval (CI) 0.79–1.8]. The results were not significantly altered after adjusting for the pre-specified potential confounders (adjusted OR 1.38; 95% CI 0.88–2.15).ConclusionIn this study, PT was not associated with a higher risk of AKI compared to cefepime or meropenem among adult critically ill patients.
Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study
Authors: Kozioł Ewelina , Skalicka-Woźniak Krystyna , Michalak Agnieszka , Kaszubska Katarzyna , Budzyńska Barbara 
Published: July 2020

Abstract
Background
The aim of this study is to preliminary evaluate the antiparkinsonian activity of furanocoumarin—xanthotoxin, in two behavioral animal models, zebrafish larvae treated with 6-hydroxydopamine and mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in order to compare both models.

Methods
Xanthotoxin was isolated from Pastinaca sativa L. (Apiaceae) fruits. Then, the compound was administered by immersion to zebrafish 5 days after fertilization (dpf) larvae or intraperitoneally to male Swiss mice, as a potential therapeutic agent against locomotor impairments.

Results
Acute xanthotoxin administration at the concentration of 7.5 µM reversed locomotor activity impairments in 5-dpf zebrafish larvae. In mice model, acute xanthotoxin administration alleviated movement impairments at the concentration of 25 mg/kg.

Conclusions
The similar activity of the same substance in two different animal models indicates their compatibility and proves the potential of in vivo bioassays based on zebrafish models. Results of our study indicate that xanthotoxin may be considered as a potential lead compound in the discovery of antiparkinsonian drugs.
Supplemental Bacillus subtilis DSM 29784 and enzymes, alone or in combination, as alternatives for antibiotics to improve growth performance, digestive enzyme activity, anti-oxidative status, immune response and the intestinal barrier of broiler chickens
Authors: Wang Yuanyuan , Heng Chianning , Zhou Xihong , Cao Guangtian , Jiang Lei , Wang Jiangshui , Li Kaixuan , Wang Dianchun , Zhan Xiuan 
Published: July 2020

AbstractThe present study investigated the effect of Bacillus subtilis DSM 29784 (Ba) and enzymes (xylanase and β-glucanases; Enz), alone or in combination (BE) as antibiotic replacements, on the growth performance, digestive enzyme activity, immune response and the intestinal barrier of broiler chickens. In total, 1200 1-d-old broilers were randomly assigned to five dietary treatments, each with six replicate pens of forty birds for 63 d as follows: (a) basal diet (control), supplemented with (b) 1 × 109 colony-forming units (cfu)/kg Ba, (c) 300 mg/kg Enz, (d) 1 × 109 cfu/kg Ba and 300 mg/kg Enz and (e) 250 mg/kg enramycin (ER). Ba, Enz and BE, similar to ER, decreased the feed conversion rate, maintained intestinal integrity with a higher villus height:crypt depth ratio and increased the numbers of goblet cells. The BE group exhibited higher expression of claudin-1 and mucin 2 than the other four groups. BE supplementation significantly increased the α-diversity and β-diversity of the intestinal microbiota and markedly enhanced lipase activity in the duodenal mucosa. Serum endotoxin was significantly decreased in the BE group. Compared with those in the control group, increased superoxide dismutase and glutathione peroxidase activities were observed in the jejunal mucosa of the Ba and BE groups, respectively. In conclusion, the results suggested that dietary treatment with Ba, Enz or BE has beneficial effects on growth performance and anti-oxidative capacity, and BE had better effects than Ba or Enz alone on digestive enzyme activity and the intestinal microbiota. Ba or Enz could be used as an alternative to antibiotics for broiler chickens.
Who Interacts with Whom? Drivers of Networked Welfare Governance in Europe
Authors: Martinsen Dorte Sindbjerg , Schrama Reini , Mastenbroek Ellen 
Published: July 2020

AbstractMigration is often perceived as a challenge to the welfare state. To manage this challenge, advanced welfare states have established transgovernmental networks. This article examines how domestic factors condition the interaction of representatives of advanced welfare states when they cooperate on transnational welfare governance. Based on new survey data, it compares who interacts with whom in one of the oldest transgovernmental networks of the European Union (EU) – the network that deals with EU citizens' rights to cross-border welfare. First, the authors perform a welfare cluster analysis of EU-28 and test whether institutional similarity explains these interactions. Furthermore, they test whether the level and kind of migration explains interaction and examine the explanatory value of administrative capacity. To test what drives interactions, the study employs social network analysis and exponential random graph models. It finds that cooperation in networked welfare governance tends to be homophilous, and that political cleavages between sending and receiving member states are mirrored in network interactions. Domestic factors are key drivers when advanced welfare states interact.
Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?
Authors: Ağbaş Ayşe , Gökalp Selman , Canpolat Nur , Çalışkan Salim , Öztunç Funda 
Published: July 2020

AbstractObjective:Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful repair of coarctation of the aorta.Methods:Twenty-five children and adolescents (mean age 13.5 ± 3.43 years) with repaired coarctation of the aorta (median age at repair 4 months, arm–leg gradient <20 mmHg) and 16 healthy controls were included. Office and ambulatory blood pressure, pulse wave velocity, and left ventricular mass index were assessed.Results:Both day- and night-time systolic blood pressure standard deviation score and left ventricular mass index were significantly higher in patients compared to controls (p ≤ 0.001 for all), whereas pulse wave velocity did not differ. The prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy were 40, 28, and 24%, respectively. Left ventricular mass index was higher in patients with sustained hypertension, masked hypertension, and normotension compared to controls (p < 0.05). In multivariate analysis, higher night-time systolic blood pressure standard deviation score was the only independent predictor of left ventricular mass index.Conclusion:The present study reveals a high prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy in children and adolescents with coarctation of the aorta even after early and successful repair. Ambulatory blood pressure monitoring should be considered to diagnose hypertension. All coarctation of aorta patients should be followed up lifelong and encouraged to establish a healthy lifestyle starting from childhood.
ON THE INVARIANCE OF GÖDEL’S SECOND THEOREM WITH REGARD TO NUMBERINGS
Authors: GRABMAYR BALTHASAR 
Published: July 2020

AbstractThe prevalent interpretation of Gödel’s Second Theorem states that a sufficiently adequate and consistent theory does not prove its consistency. It is however not entirely clear how to justify this informal reading, as the formulation of the underlying mathematical theorem depends on several arbitrary formalisation choices. In this paper I examine the theorem’s dependency regarding Gödel numberings. I introducedeviantnumberings, yielding provability predicates satisfying Löb’s conditions, which result in provable consistency sentences. According to the main result of this paper however, these “counterexamples” do not refute the theorem’s prevalent interpretation, since once a natural class ofadmissiblenumberings is singled out, invariance is maintained.
COMPLEXITY OF THE INFINITARY LAMBEK CALCULUS WITH KLEENE STAR
Authors: KUZNETSOV STEPAN 
Published: July 2020

AbstractWe consider the Lambek calculus, or noncommutative multiplicative intuitionistic linear logic, extended with iteration, or Kleene star, axiomatised by means of an$\omega $-rule, and prove that the derivability problem in this calculus is$\Pi _1^0$-hard. This solves a problem left open by Buszkowski (2007), who obtained the same complexity bound for infinitary action logic, which additionally includes additive conjunction and disjunction. As a by-product, we prove that any context-free language without the empty word can be generated by a Lambek grammar with unique type assignment, without Lambek’s nonemptiness restriction imposed (cf. Safiullin, 2007).
The Water‐Saturated Solidus and Second Critical Endpoint of Peridotite: Implications for Magma Genesis Within the Mantle Wedge
Authors: Wang Jintuan , Takahashi Eiichi , Xiong Xiaolin , Chen Linli , Li Li , Suzuki Toshihiro , Walter Michael J. 
Published: July 2020

AbstractThe “wet” silicate solidus of mantle peridotite defines the initial melting temperature of Earth's mantle under water‐saturated conditions and the second critical endpoint (SCEP) marks the high P‐T end of the wet solidus. However, the location of the wet solidus has remained an outstanding issue for over 50 years and the position of the SCEP is hotly debated. Published wet solidi show a difference of 200–600°C at a given pressure while reported SCEPs range from <4 to >6 GPa. Using a large‐volume multianvil apparatus, we investigated the water‐saturated melting behavior of a fertile peridotite at 3–6 GPa, 950–1200°C, and obtained well‐preserved quenched materials. On the basis of textures and compositions of the quenched materials, we bracket the wet solidus to between 950°C and 1000°C at 3 GPa and the SCEP between 3 and 4 GPa. Combining our experimental results with seismologic and petrologic observations, we propose that the lithosphere‐asthenosphere boundary in subduction zones should be constrained by the wet solidus and emphasize the role of a deep hydrous partial‐melting zone (DHPMZ) on magma genesis within the mantle wedge. We suggest that the DHPMZ is a source of hydrous melts to the primary melting zone in the mantle wedge and that the position of the volcanic front and its magma production rate may largely be controlled by melting and melt segregation processes within the DHPMZ. Our experimental results also suggest that high‐magnesian magmas (e.g., boninite, picrite, and komatiite) could be formed at conditions representative of subduction zones.
Friction of Longmaxi Shale Gouges and Implications for Seismicity During Hydraulic Fracturing
Authors: An Mengke , Zhang Fengshou , Elsworth Derek , Xu Zhengyu , Chen Zhaowei , Zhang Lianyang 
Published: July 2020

AbstractLongmaxi formation shales are the major target reservoir for shale gas extraction in Sichuan Basin, southwest China. Swarms of earthquakes accompanying hydraulic fracturing are observed at depths typifying the Longmaxi formation. Mineral composition varies broadly through the stratigraphic section due to different depositional environments. The section is generally tectosilicate‐poor and phyllosilicate‐rich with a minor portion the converse. We measure the frictional and stability properties of shale gouges taken from the full stratigraphic section at conditions typifying the reservoir depth. Velocity‐stepping experiments were performed on representative shale gouges at a confining pressure of 60 MPa, pore fluid pressure of 30 MPa, and temperature of 150°C. Results show the gouges are generally frictionally strong with friction coefficients ranging between 0.50 and 0.75. Two phyllosilicate + TOC (total organic carbon)‐poor gouges exhibited higher frictional strength and velocity weakening, capable of potentially unstable fault slip, while only velocity strengthening was observed for the remaining phyllosilicate + TOC‐rich gouges. These results confirm that the frictional and stability properties are mainly controlled by phyllosilicate + TOC content. Elevating the temperature further weakens the gouges and drives it toward velocity weakening. The presence of observed seismicity in a majority of velocity‐strengthening materials suggests the importance of the velocity‐weakening materials. We suggest a model where seismicity is triggered when pore fluid pressures drive aseismic slip and triggers seismic slip on adjacent faults in the same formation and distant faults in the formations above/below. The effect of pore pressure transients within low‐permeability shale gouges is incorporated. Our results highlight the importance of understanding mechanisms of induced earthquakes and characterizing fault properties prior to hydraulic fracturing.
Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway
Authors: Shi Yuan-Fei , Liu Long , He Ling-Li , Ye Jing , Lin Zhi-Juan , Yuan De-Lin , Deng Man-Man , Fang Zhi-Hong , Carter Bing Z. , Xu Bing 
Published: July 2020

AbstractBcl-2 inhibitors display an effective activity in acute myeloid leukemia (AML), but its clinical efficacy as a monotherapy was limited in part owing to failure to target other antiapoptotic Bcl-2 family proteins, such as Mcl-1. In this context, the combination strategy may be a promising approach to overcome this barrier. Here, we report the preclinical efficacy of a novel strategy combining ABT-199 with triptolide (TPL), a natural product extracted from a traditional Chinese medicine, in AML. Combination treatment exhibited markedly increased cytotoxicity in leukemic cells irrespective of p53 status while largely sparing normal cells of the hematopoietic lineage. Moreover, co-administration of ABT-199 with TPL dramatically suppressed leukemia progression as well as prolonged animal survival in a xenograft AML model. The potentiated effect of ABT-199 and TPL against AML was associated with activation of the mitochondrum-related intrinsic apoptotic pathway through a mechanism reciprocally modulating Bcl-2 family proteins. In this case, TPL not only downregulated Mcl-1 but also upregulated proapoptotic BH3-only proteins, thereby overcoming the resistance toward ABT-199. Conversely, ABT-199 abrogated Bcl-2-mediated cytoprotection against TPL. Together, these findings suggest that the regimen combining TPL and ABT-199 might be active against AML by inducing robust apoptosis through reciprocal regulation of anti- and proapoptotic Bcl-2 family proteins, therefore providing a strong rationale for the clinical investigation of this combination regimen for the treatment of AML.
sTim-3 alleviates liver injury via regulation of the immunity microenvironment and autophagy
Authors: Yang Ying , Ying Gaoxiang , Wu Fengtian , Chen Zhi 
Published: July 2020

AbstractLiver failure (LF) is a monocyte/macrophage-mediated liver injury that has been associated with inflammatory mediators. However, the mechanism through which monocytes/macrophages regulate LF has not been fully elucidated. In this study, we investigated the role of soluble T-cell immunoglobulin domain and mucin domain-containing molecule-3 (sTim-3) in inhibition of release of inflammatory mediators. We further assess this role in protection against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver failure (ALF), via monocyte/macrophage regulation and autophagy induction in mice. Our findings indicate significantly higher plasma sTim-3 in acute-on-chronic liver failure (ACLF) group relative to other groups, with this trend associated with disease progression. Furthermore, infiltrated recombinant sTim-3 inhibited release of various inflammatory mediators, including cytokines and human high-mobility group box-1 (HMGB1), potentially via autophagy induction. Furthermore, H&E staining and the low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in ALF mice, supported that recombinant sTim-3 effectively alleviated liver injury. Moreover, sTim-3 induced changes in monocyte/macrophage population in mice’s liver or blood, which consequently caused a reduction in proinflammatory CD11bhiF4/80lo monocyte-derived macrophages and Ly-6C(+)CD11b(+) monocytes. Conversely, sTim-3 increased autophagy levels of hepatic CD11b(+) monocyte-derived macrophages and decreased apoptosis rate of CD11b (+) monocytes in the blood. Collectively, our findings demonstrated that sTim-3 alleviated inflammatory response and liver injury by promoting autophagy and regulating monocyte/macrophage function. This indicates its potential for future development of novel therapeutic strategies against LF.
Ligand engineering to achieve enhanced ratiometric oxygen sensing in a silver cluster-based metal-organic framework
Authors: Dong Xi-Yan , Si Yubing , Yang Jin-Sen , Zhang Chong , Han Zhen , Luo Peng , Wang Zhao-Yang , Zang Shuang-Quan , Mak Thomas C. W. 
Published: July 2020

AbstractRatiometric luminescent oxygen sensing based on dual fluorescence and phosphorescence emission in a single matrix is highly desirable, yet the designed synthesis remains challenging. Silver-chalcogenolate-cluster-based metal-organic frameworks that combine the advantages of silver clusters and metal-organic frameworks have displayed unique luminescent properties. Herein, we rationally introduce −NH2 groups on the linkers of a silver-chalcogenolate-cluster-based metal-organic framework (Ag12bpy-NH2) to tune the intersystem crossing, achieving a dual fluorescence-phosphorescence emission from the same linker chromophore. The blue fluorescence component has a 100-nm gap in wavelength and 8,500,000-fold difference in lifetime relative to a yellow phosphorescence component. Ag12bpy-NH2 quantifies oxygen during hypoxia with the limit of detection of as low as 0.1 ppm and 0.3 s response time, which is visualized by the naked eye. Our work shows that metal cluster-based MOFs have great potential in luminescent sensing, and the longer-lived charge-separated states could find more photofunctional applications in solar energy transformation and photocatalysis.