bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preserving Destruction: Philosophical Issues of Urban Geosites
Authors: Capdevila-Werning Remei 
Published: September 2020

AbstractThis article examines the philosophical issues that arise when preserving urban geological sites or urban geosites. These are preserved not only because of their geological value but also because of aesthetic, cultural, and economic reasons. To do so, it examines the geosite constituted by Olot and its surroundings, a city in Spain that extends amid four dormant volcanoes. It explores the metaphysical paradox that these geosites have become what they are due to the preservation of destruction: human-caused interventions, mostly extraction of materials and exploitation of the land, are precisely what made these geosites visible as sites worth preserving and determining their metaphysical status. It further explores the preservation criteria and shows how they have determined the status of the geosite. Second, it shows how in such urban geosites the collapse of two diametrically opposed conceptions of time – the geological eon and the lived human time – occurs. Lastly, it discusses aesthetic aspects of such geosites by considering aesthetic experience as a primarily cognitive endeavor and shows how metaphysical, epistemological, and aesthetic issues of preservation of geosites are inextricably linked.
Metabolic complications in acromegaly after neurosurgery: a meta-analysis
Authors: Cozzolino Alessia , Feola Tiziana , Simonelli Ilaria , Puliani Giulia , Hasenmajer Valeria , Minnetti Marianna , Giannetta Elisa , Gianfrilli Daniele , Pasqualetti Patrizio , Lenzi Andrea , Isidori Andrea M 
Published: September 2020

Objective
Neurosurgery is the first-line treatment for acromegaly. Whether metabolic disorders are reversible after neurosurgery is still debated. The meta-analysis aimed to address the following questions: (i) Does neurosurgery affect glycolipid metabolism? (ii) Are these effects related to disease control or follow-up length?

Design
A meta-analysis and systematic review of the literature.

Methods
Three reviewers searched databases until August 2019 for prospective trials reporting glycometabolic outcomes after neurosurgery. Three other extracted outcomes, all assessed the risk of bias.

Results
Twenty studies were included. Neurosurgery significantly reduced fasting plasma glucose (FPG) (effect size (ES): −0.57 mmol/L, 95% CI: −0.82 to −0.31; P < 0.001), glucose load (ES: −1.10 mmol/L, 95% CI: −1.66 to −0.53; P < 0.001), glycosylated haemoglobin (HbA1c) (ES: −0.28%, 95% CI: −0.42 to −0.14; P < 0.001), fasting plasma insulin (FPI) (ES: −10.53 mU/L, 95% CI: −14.54 to −6.51; P < 0.001), homeostatic model assessment of insulin resistance (HOMA-IR) (ES: −1.98, 95% CI: −3.24 to −0.72; P = 0.002), triglycerides (TGDs) (ES: −0.28 mmol/L, 95% CI: −0.36 to −0.20; P < 0.001) and LDL-cholesterol (LDLC) (ES: −0.23 mmol/L, 95% CI: −0.45 to −0.02 mmol/L); P = 0.030) and increased HDL-cholesterol (HDLC) (ES: 0.21 mmol/L, 95% CI: 0.14 to 0.28; P < 0.001). Meta-regression analysis showed that follow-up length – not disease control – had a significant effect on FPG, with the greatest reduction in the shortest follow-up (beta = 0.012, s.e. = 0.003; P = 0.001).

Conclusions
Neurosurgery improves metabolism with a significant decrease in FPG, glucose load, HbA1c, FPI, HOMA-IR, TGDs, and LDLC and increase in HDLC. The effect on FPG seems to be more related to follow-up length than to disease control.
Synaptopodin Is Dispensable for Normal Podocyte Homeostasis but Is Protective in the Context of Acute Podocyte Injury
Authors: Ning Liang , Suleiman Hani Y. , Miner Jeffrey H. 
Published: September 2020

Significance Statement
Synaptopodin is a podocyte actin-binding protein that regulates the cytoskeleton. Despite the cytoskeleton's critical role in podocytes and its alteration in nephrotic syndrome and FSGS, mutations in the synaptopodin gene SYNPO have not been reported in patients. Studies in Synpo mutant mice suggest that a truncated form of synaptopodin partially compensates for loss of the full-length protein. Experiments using newly generated Synpo mutant mice demonstrated that complete absence of synaptopodin did not cause a phenotype, but it increased susceptibility to Adriamycin nephropathy, an FSGS model. In cultured podocytes from the mice, absence of synaptopodin altered the cytoskeleton. These findings indicate that synaptopodin is dispensable for normal podocyte homeostasis but is protective in injured podocytes, suggesting the cytoskeleton as a target for therapeutic intervention in podocytopathies.

Background
Synaptopodin (Synpo) is an actin-associated protein in podocytes and dendritic spines. Many functions in regulating the actin cytoskeleton via RhoA and other pathways have been ascribed to Synpo, yet no pathogenic mutations in the SYNPO gene have been discovered in patients. Naturally occurring Synpo isoforms are known (Synpo-short and -long), and a novel truncated version (Synpo-T) is upregulated in podocytes from Synpo mutant mice. Synpo-T maintains some Synpo functions, which may prevent a podocyte phenotype from emerging in unchallenged mutant mice.

Methods
Novel mouse models were generated to further investigate the functions of Synpo. In one, CRISPR/Cas9 deleted most of the Synpo gene, preventing production of any detectable Synpo protein. Two other mutant strains made truncated versions of the protein. Adriamycin injections were used to challenge the mice, and Synpo functions were investigated in primary cultured podocytes.

Results
Mice that could not make detectable Synpo (Synpo

−/−
) did not develop any kidney abnormalities up to 12 months of age. However, Synpo

−/−
mice were more susceptible to Adriamycin nephropathy. In cultured primary podocytes from mutant mice, the absence of Synpo caused loss of stress fibers, increased the number and size of focal adhesions, and impaired cell migration. Furthermore, loss of Synpo led to decreased RhoA activity and increased Rac1 activation.

Conclusions
In contrast to previous findings, podocytes can function normally in vivo in the absence of any Synpo isoform. Synpo plays a protective role in the context of podocyte injury through its involvement in actin reorganization and focal adhesion dynamics.
Towards a Disentanglement of the Links between the Memory Boom and the Neoliberal Turn
Authors: Cercel Cristian 
Published: September 2020

The memory boom and the related emergence of cosmopolitan victimhood-centred memories, increasingly criticized for depoliticizing the past and thus contributing to the depoliticization of the present, have been simultaneous with the curtailment of the welfare state, the abandonment of the politics of redistribution, the erosion of social and economic rights, and the growth in social and economic inequalities. Yet if the latter are often being considered to be among the reasons leading to the current right-wing populist wave in Europe and elsewhere or at least are seen as entangled therewith, the relevance of the memory boom for these developments has not been properly interrogated.
Against this background, this contribution makes a plea for a critical appreciation of the linkages between the memory boom and the global ascension of neoliberalism. It acknowledges the contemporaneity of the two phenomena, which have been fundamentally informing our present age, roughly since the end of the 1970s, and calls for a critical engagement with their interwoven character. In doing this, it argues that scholarship should pay particular attention to the relationship between past, present, and future that the neoliberal turn in its various shapes and guises implies, as well as to the regimes of temporality that underlie various instantiations of the memory boom. It ends by taking heed of recent theorizations in memory studies and by asking to what extent can they be used in order to have a better grasp of the critical juncture we are currently lying at and to contribute to a radical change of the political status quo. Thus, the article makes some preliminary steps towards disentangling the interconnections between the memory boom and the neoliberal turn, and aims to provide a blueprint for a substantial future research project that should look in depth at these entanglements.
Political Representation and Spokespersons in the Prostitution vs. Sex Work Debate
Authors: Katona Noémi 
Published: September 2020

A binary debate has developed internationally between abolitionists and sex workers’ rights (SWR) activists: this involves the so-called ‘sex wars’, which dominate the scholarship and activism regarding commercial sex worldwide. While abolitionists aim to eliminate prostitution, which they see as a manifestation of patriarchy and violence against women, SWR activists aim to recognize sex work as work, and to fight for better working conditions in the sex industry. Both movements have become institutionalized, and various local NGOs and international networks have been established to advocate for these political aims. These organizations try to influence national and international legislation regarding the selling of sex by building powerful alliances. The financial support of donors is also dependent on how compatible these movements are with neoliberal power relations. Furthermore, the development and political influence of local abolitionist or sex worker movements also depends on countries’ positions in the global economy.
The paper analyses the political representation and the role of spokespersons within the prostitution/sex work debate and also reflects on the advocacy work of Hungarian organizations active in this field since 1989. It discusses the evolution of a politics of recognition in the struggle related to commercial sex, and how transnational power dynamics on a global scale have affected Hungarian movements and civil society organizations since the era of state socialism.
How are Online and Offline Political Activities Connected?
Authors: Angyal Emese Éva , Fellner Zita 
Published: September 2020

In general, political participation means all the action of citizens that has the aim or the effect of influencing government or politics. Studies argue that media consumption and political participation are correlated: offline and online political participation affect each other. Knowing the relationship between online and offline political activity can improve estimations of offline political events based on social media data.
By comparing these empirical results, in this study we investigate whether social media usage reinforces or weakens the willingness to become involved in a demonstration or other offline political activity. Numerous studies have already attempted to measure this effect, with contradictory findings related to the direction and volume of the latter.
We explore this connection by synthesizing recent empirical political science papers. For this purpose, we compare the results of the former using Bayesian updating – a tool for comparing studies regardless of their methodology or data collection method. This method of data analysis is also insensitive to the operationalization of either the dependent or the explanatory variables.
Based on the aforementioned studies, our results prove that online political activity has a significant positive effect on offline political activity, in spite of the fact that some research has found an insignificant connection.
ATTRACTION OF INVESTMENTS USING THE OFFSET AGREEMENT
Authors: Petrakov A. Y. 
Published: September 2020

The article is devoted to an offset agreement (a state agreement which is providing for counter-investment obligations of a supplier-investor to create or modernize and (or) develop production of goods in the territory of a subject of the Russian Federation to provide the state needs of a subject of the Russian Federation). In addition to the legal regulation of offset agreements, their subject composition is also determined, and the features of their conclusion are highlighted. The study analyzed all 4 offset contracts currently signed in Moscow and the Moscow region. According to the author, the offset agreement is an investment agreement, and the interaction of the subject of the Russian Federation and the supplier-investor in the implementation of the offset agreement can be qualified as a public-private partnership that is beneficial to both the state and business: the benefits that are received by the subject of the Russian Federation and the supplier-investor are given. As an improvement of the legal regulation of offset agreements, the author suggests providing for the possibility of concluding them at the federal level, as well as differentiating the minimum investment volume depending on the level of socio-economic development of the subject of the Russian Federation. The conclusion is made that public-private partnership, carried out in the analyzed form of agreement, is a promising mechanism for attracting investment in the constituent entities of the Russian Federation.
ON THE SUBJECTS OF COMMERCIAL (TRADE) LAW
Authors: Kuznetsova N. V. 
Published: September 2020

The article examines the system of subjects of commercial (trade) law, as well as the criteria for their classification. In the doctrine of commercial (commercial) law, the problem of distinguishing its subjects and their legal features has remained controversial for many years. The author pays special attention to the concept and legal characterization of such ambiguously determined trading participants as resellers and trade facilitators. The author considers the features of the legal status of participants in trade relations, which allow them to be attributed to a certain category of subjects of commercial law.The article also examines the problems of changing the subject composition of trade relations in the context of the development of digital technologies and electronic commerce. In this regard, the norms of legislation and the positions of lawyers are analyzed with respect to new categories of participants in trade relations, the activity of which has become widespread in the process of developing Internet commerce — aggregators, as well as subjects of the information infrastructure of trade — the so-called information intermediaries and other persons providing commercial services in the global network.
O Ensino de Matemática nas Páginas da Revista Educação em Mato Grosso (1978-1986)
Authors: Stascovian Juliana , Almeida Laura Isabel Marques Vasconcelos de 
Published: September 2020

O artigo é resultado da pesquisa de Mestrado intitulada Revista Educação em Mato Grosso: orientações pedagógicas sobre a disciplina de Matemática para o Ensino Primário nas escolas públicas mato-grossenses (1978-1986). O estudo retrata o ensino de Matemática sob o olhar da Revista Educação em Mato Grosso - REMT elaborada e socializada pela Secretaria de Estado de Educação de Mato Grosso - SEDUC/MT com o objetivo de formar os professores primários e aproximar o órgão governamental dos profissionais da educação. Ancorado na abordagem metodológica histórico-cultural, a pesquisa fundamentou-se em autores renomados que discutem com propriedade os conceitos de apropriação, cultura escolar, imprensa pedagógica e formação de professores contribuindo para a historiografia da educação matemática. Os dados revelam que além de vasta informação, a Revista oferecia sugestões de trabalho e partilha de experiências bem-sucedidas realizadas pelas unidades escolares, contribuindo com o processo de ensino aprendizagem nas escolas públicas primárias mato-grossenses.

Palavras-chave: Ensino de Matemática. Impresso Pedagógico. Formação de Professores.

Abstract
The article is the result of a Master's research entitled Revista Educação em Mato Grosso: pedagogical guidelines on the subject of Mathematics for Primary Education in public schools in Mato Grosso (1978-1986). The study portrays the Mathematics Teaching from the perspective of “Revista Educação em Mato Grosso (REMT),” which was thought, elaborated and socialized by the Mato Grosso State Secretariat of Education (SEDUC / MT) with the objective of training primary teachers and bring the government agency closer to education professionals. Anchored in the historical-cultural methodological approach, the research was based on renowned authors who discuss appropriately the concepts of appropriation, school culture, pedagogical press and teacher education, contributing to the mathematics education historiography. The data reveal that in addition to extensive information, the magazine offered work suggestions and shared successful experiences carried out by the school units, contributing to the teaching-learning process in public primary schools in Mato Grosso.

Keywords: Mathematics Teaching. Pedagogical Form. Teacher Training.
Análise de Materiais Educativos Utilizados nas Campanhas de Saúde Coletiva Sobre o Tabagismo
Authors: Sales Antonio , Peres Rodrigues Mariana , Marques da Silva Santos Matheus , Marcelino Stilben de Souza Giovana , Araujo Bento Leda Marcia 
Published: September 2020

Este artigo é resultado de uma pesquisa documental tendo como base a análise de um material educativo elaborado com a finalidade de conscientizar a população sobre os malefícios do tabagismo. O documento analisado foi retirado do site da Fundação Portuguesa de Cardiologia em consideração ao dia nacional do não fumador. Contém uma revisão bibliográfica sobre os inconvenientes do tabaco, os males que acarreta e as substâncias nocivas que apresenta. Como referencial teórico foi utilizada a tipologia de conteúdos de ensino proposta por Antoni Zabala e a análise considerou os tipos de conteúdo presentes no material utilizado na referida campanha. Após o estudo concluiu-se que o material aborda vários tipos de conteúdos, podendo assim, contribuir para a sensibilização da população-alvo tendo potencial para induzir a uma atitude de mudança além de atingir a população não fumante como modo de prevenção em saúde.

Palavras-chave: Materiais Educativos. Campanhas de Saúde. Educação em Saúde.

Abstract
This article is the documentary research’s result based on an educational material elaborated with the aim of making the population aware about the damages from smoking. The analyzed document was taken from the site of Cardiology’s Portuguese Foundation in consideration of the non-smoker national’s day. It contains a bibliographic review about the inconveniences of tobacco, the illness that it entails and the harmful substances it presents. The typology of teaching contents proposed by Antoni Zabala was used as a theoretical reference and the analysis considered the types of contents present in the material applied in that campain. After the research it was concluded that the material addresses several types of contents, thus contributing to the vulnerability of smoking population with te potential to induce a change’s attitude besides affecting the non-smoker population as a way of health’s prevention.

Keywords: Educational Materials. Health Campaigns. Health Education.
A Análise do Videoclipe Sob a Perspectiva da Análise do Discurso Francesa para o Ensino da Língua Inglesa
Authors: Zimmer Rosangela , Ferreira Azevedo Lucy 
Published: September 2020

As vivências como professora na área da língua inglesa da Educação Básica me motivaram a estudar leitura. A inquietação que surgiu foi: contextualizar culturalmente os temas propostos levaria o aluno a pensar a língua estrangeira com criticidade e consciência das diferenças entre esta e sua língua nativa? Nesta perspectiva, o objetivo deste artigo é documentar uma oficina de leitura em que houve a relação história e arte com critérios definidores do modo de funcionamento da Análise do Discurso francesa e a sua orientação em direção a problemas práticos do cotidiano, relacionados à língua e à comunicação. Para tanto, o estudo analisou e desenvolveu a leitura de um clipe em língua inglesa do ponto de vista da vida contemporânea, repensando o seu objeto de estudo, a escola, os alunos e os professores em diferentes contextos: corpo, etnia, nacionalidade, gênero, classe social, entre outros tópicos, conforme os textos estudados. O método de abordagem foi qualitativo, em pesquisa descritiva e bibliográfica com base nos autores da área da Análise do Discurso francesa, em apenas um clipe, entre oito oficinas compostas de clipes com temas diversificados em linguagem conotativa. Espera-se que o estudo aqui proposto culmine em um ensino que leve o estudante a pensar a outra cultura e, com ela, outras habilidades e competências em língua inglesa e consequentemente evolua com maior fluidez.

Palavras-chave: Ensino. Língua Inglesa. Videoclipe.

Abstract
The experiences as a teacher in the English language area of ​​Basic Education motivated me to study reading. The concern that arose was to culturally contextualizing the proposed themes lead the student to think the foreign language with criticism and awareness of the differences between it and his native language? In this perspective, the aim of this article is to document a reading workshop in which there was a relationship between history and art with defining criteria of the way French Discourse Analysis works and its orientation towards practical everyday problems related to language and communication. To this end, the study analyzed and developed the reading of an English-language clip from the point of view of contemporary life, rethinking its object of study, school, students and teachers in different contexts: body, ethnicity, nationality, gender, social class, among other topics, according to the texts studied. The method of approach was qualitative, in descriptive and bibliographical research based on the authors of the French Discourse Analysis area, in only one clip, among eight workshops with clips with diverse themes in connotative language. It is expected that the study proposed here will culminate in a teaching that leads the student to think about another culture and, with it, other skills and competences in English language and consequently evolve with greater fluidity.

Keywords: Teaching. English Language. Video Clip.