bluuebunny/crossref_metadata_2025_split huggingface dataset:
What if I am the one? Measuring individual differences in emotional sensitivity to probability and emotional reactivity to possibility
Authors: Lacey Heather P. , Lacey Steven C. , Scherer Laura D. , Zikmund‐Fisher Brian J. 
Published: June 2020

AbstractCurrent theories of risk perception point to the powerful role of emotion and the neglect of probabilistic information in the face of risk, but these tendencies differ across individuals. We propose a method for measuring individuals' emotional sensitivity to probability to assess how feelings about probabilities, rather than the probabilities themselves, influence decisions. Participants gave affective ratings (worry or excitement) to 14 risky events, each with a specified probability ranging from 1 in 10 to 1 in 10,000,000. For each participant, we regressed these emotional responses against item probabilities, estimating a slope (the degree to which emotional responses change with probability) and an intercept (the emotional reaction to an event with a fixed probability). These two parameters were treated as individual difference scores and included in models predicting reactions to several health risk scenarios. Both emotional sensitivity to probability (slope) and emotional reactivity to possibility (intercept) significantly predicted responses to these scenarios, above and beyond the predictive power of other well‐established individual difference measures.
Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction
Authors: Yang Jingyi , Gao Yan 
Published: June 2020

AbstractBackground and purposePrevious studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin‐1 and atherosclerotic acute cerebral infarction (ACI).MethodsIn this study, we investigated the association between serum omentin‐1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI.ResultsA total of 109 patients with atherosclerotic ACI were enrolled. Serum omentin‐1 levels at admission were lower in patients with ACI than those in healthy controls (47.18 ± 13.64 vs. 56.27 ± 34.44 ng/ml, p = .014). Serum omentin‐1 levels at admission were negatively correlated with severity of ACI (r = −.271, p = .004) and infarction volume (r = −.264, p = .006), respectively. Moreover, serum omentin‐1 levels were lower in the poor functional prognosis group than those in the good functional prognosis group in patients with large artery and small artery atherosclerotic ACI. In a logistic regression analysis, higher serum omentin‐1 level (>43.10 ng/ml) at admission was negatively associated with a poor functional prognosis 90 days after atherosclerotic ACI.ConclusionsSerum omentin‐1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin‐1 level (>43.10 ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin‐1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin‐1 level as a potential biomarker.
One‐year outcomes of patients undergoing complex percutaneous coronary intervention with three contemporary drug‐eluting stents
Authors: Azzalini Lorenzo , Baber Usman , Johal Gurpreet S. , Farhan Serdar , Barman Nitin , Kapur Vishal , Hasan Choudhury , Vijay Pooja , Jhaveri Vaishvi , Mehran Roxana , Kini Annapoorna S. , Sharma Samin K. 
Published: June 2020

AbstractObjectivesWe aimed to evaluate the 1‐year outcomes of three everolimus‐eluting stents (EES) for complex percutaneous coronary intervention (PCI).BackgroundIt is controversial whether contemporary bioresorbable‐polymer drug‐eluting stents (BP‐DES) are associated with better outcomes compared with durable‐polymer DES (DP‐DES).MethodsPatients undergoing PCI with cobalt‐chromium (CoCr)‐DP‐EES (Xience), platinum‐chromium (PtCr)‐DP‐EES (Promus), or PtCr‐BP‐EES (Synergy) at one high‐volume institution between 2015 and 2017 were included. The primary endpoint was 1‐year major adverse cardiac events (MACE), a composite of death, myocardial infarction, and target‐vessel revascularization. Associations were also examined in patients undergoing complex PCI. Multivariable analysis was conducted to adjust for baseline differences across groups.ResultsWe included n = 5,446 patients (CoCr‐DP‐EES, n = 3,177; PtCr‐DP‐EES, n = 1,555; PtCr‐BP‐EES, n = 714). Patients treated with PtCr‐BP‐EES had higher comorbidity burden and procedural complexity. At 1 year, MACE rates were 8.9% for CoCr‐DP‐EES versus 8.9% for PtCr‐DP‐EES versus 8.6% for PtCr‐BP‐EES (p = .97). The incidence of definite/probable stent thrombosis (ST) was also similar (0.6 vs. 0.4 vs. 0.3%, p = .69). Complex PCI was performed in n = 2,894/5,446 (53.1%). At 1 year, MACE rates were 11.5 versus 10.7 versus 10.3%, respectively (p = .83). The incidence of definite/probable ST was also similar (0.9 vs. 0.3 vs. 0.3%, p = .22). On multivariable analysis, stent type was not an independent predictor of MACE either in the overall or in the complex PCI population.ConclusionsWe observed comparable 1‐year rates of MACE and definite/probable ST in patients undergoing PCI with CoCr‐DP‐EES, PtCr‐DP‐EES, and PtCr‐BP‐EES. Results were unchanged among patients undergoing complex PCI. Future multicenter randomized studies should confirm and extend our findings.
Phosphate Ion‐Functionalized CoS with Hexagonal Bipyramid Structures from a Metal–Organic Framework: Bifunctionality towards Supercapacitors and Oxygen Evolution Reaction
Authors: Jiang Jiahui , Xu Jinling , Wang Weiwei , Zhang Li , Xu Guancheng 
Published: June 2020

AbstractTo solve energy‐related environmental problems and the energy crisis, efficient electrochemical materials have been developed as alternative energy storage and conversion systems. Abundant transition metals and their sulfides are attractive electrochemical materials. Herein, we report an efficient phosphorization strategy, which improves the overall electrochemical performance of metal sulfides. In detail, CoS hexagonal bipyramids were synthesized through simple calcination combined with in situ sulfurization of a cobalt‐based metal–organic framework template, and then phosphate ion‐functionalized CoS (P‐CoS) was prepared through a phosphorization reaction. P‐CoS exhibited outstanding electrochemical activity as both supercapacitor electrode and oxygen evolution reaction (OER) catalyst. Supercapacitors based on CoS and P‐CoS as the electrodes had high specific capacitances of 304 and 442 F g−1, respectively, and remained stable for over 10 000 cycles at 5 A g−1. For OER, P‐CoS showed a current density of 10 mA cm−2 at an overpotential of 340 mV, with a small Tafel slope. In conclusion, functionalizing CoS with phosphate ions is a promising method for enhancing chemical reactivity and accelerating ion and electron transfer.
Covalent Attachment of Active Enzymes to Upconversion Phosphors Allows Ratiometric Detection of Substrates
Authors: Burgess Letitia , Wilson Hannah , Jones Alex R. , Harvey Peter , Natrajan Louise S. , Hay Sam 
Published: June 2020

AbstractUpconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Here, UCPs were capped with functionalized silica in order to provide a surface to covalently conjugate proteins with surface‐accessible cysteines. Variants of green fluorescent protein (GFP) and the flavoenzyme pentaerythritol tetranitrate reductase (PETNR) were then attached via maleimide‐thiol coupling in order to allow energy transfer from the UCP to the GFP or flavin cofactor of PETNR, respectively. PETNR retains its activity when coupled to the UCPs, which allows reversible detection of enzyme substrates via ratiometric sensing of the enzyme redox state.
Single‐cell profiling of pediatric T‐cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK–STAT signaling pathways
Authors: Bonaccorso Paola , Bugarin Cristina , Buracchi Chiara , Fazio Grazia , Biondi Andrea , Lo Nigro Luca , Gaipa Giuseppe 
Published: June 2020

AbstractBackgroundThe PI3K/Akt/mTOR (PI3K) signaling pathway has a crucial role in T‐cell acute lymphoblastic leukemias (T‐ALLs). Although loss‐of‐function of phosphatase and tensin homolog (PTEN) is a common event in pediatric T‐ALLs, the exact role of this tumor suppressor in T‐ALL development has yet to be defined.MethodsHere, we report an optimized cytometric method for accurate proteomic profiling of T‐ALL leukemic blasts at single‐cell level. We determined the expression of PI3K and JAK–STAT signaling components in both primary and immortalized T‐ALL cells as well as in normal T cells.ResultsWe observed that PTEN exon 7 mutated T‐ALL cells retain a distinct PI3K activation; in particular, these cells show higher pAkt levels and a lower pS6 expression. Interestingly, we demonstrated for the first time that PTEN exon 7 mutated T‐ALL are nonresponsive to IL7 in vitro as assessed by lack of pSTAT5 activation, although they do express IL7R.ConclusionsPhosphoflow analysis represents a fast, reliable, and accurate method to study the signaling profile of T‐ALL. PTEN exon 7 mutated T‐ALL cells are nonresponsive to IL7 in vitro suggesting that they may activate other mechanisms to support their viability and proliferation such as a higher constitutive PI3K/Akt signaling. Further investigations are necessary to elucidate the significance of this peculiar signaling behavior. Our observations should be taken into account in future studies aiming at molecular targeting of PI3K and/or JAK/STAT pathways for pharmacological intervention in T‐ALL.
Comparison of three methods to stabilize bronchoalveolar lavage cells for flowcytometric analysis
Authors: Eidhof Harrie H. M. , Gratama Jan W. , Mulder A. H. Leontine 
Published: June 2020

AbstractBackgroundFlowcytometric analysis of lymphocytes and their subpopulations in bronchoalveolar lavages (BAL) can support the diagnosis of interstitial lung diseases. This analysis should be done within 4 hr after lavage due to rapid cell deterioration. We tested three methods in order to stabilize for at least 28 days the BAL cell populations to allow delayed flowcytometric analysis in order to facilitate external quality assurance (EQA).MethodsWe compared an in‐house, dual‐step stabilization method for BAL cells with results of two different commercial available stabilization reagents: TransFix® and Streck Cell Preservative™. All three methods were compared with native BAL cells as reference. BAL samples from six patients were tested on six occasions following stabilization from 1 to 28 days by flow cytometry.ResultsFollowing stabilization and storage at 4°C, BAL cell suspensions had stable light scatter patterns and lymphocyte subsets. As expected, rapid deterioration of cells was seen with native BAL cells. The stabilized lavages showed more stable counts of WBC and lymphocyte populations with only minor differences found between the three methods.ConclusionsIf analysis of the BAL cells is performed more than 24 hr after the lavage, stabilized BAL cells are superior to native cells. The in‐house method can be used for EQA purposes with stability for at least 28 days. The TransFix and Streck methods might be useful for postponed diagnostic analysis of lavage cells but did not meet our 28 days criterion defined needed for EQA purposes.
Development and validation of liquid chromatography‐tandem mass spectrometry targeted screening of 16 fentanyl analogs and U‐47700 in hair: Application to 137 authentic samples
Authors: Larabi Islam Amine , Martin Marie , Etting Isabelle , Pfau Gregory , Edel Yves , Alvarez Jean Claude 
Published: June 2020

AbstractThis study was to validate a LC–MS/MS method for the determination of 17 new synthetic opioids (NSOs) in hair including 3‐fluorofentanyl, 3‐methylfentanyl, acetylfentanyl, acetylnorfentanyl, alfentanyl, butyrylfentanyl, butyrylnorfentanyl, carfentanil, fentanyl, furanylfentanyl, furanylnorfentanyl, methoxyacetylfentanyl, norcarfentanil, norfentanyl, ocfentanil, sufentanil, and U‐47700, and to apply it to 137 authentic samples. Twenty milligrams of hair was decontaminated in dichloromethane and underwent liquid extraction. 10 μL of the reconstituted residue were injected onto the system. The separation was performed in 12 minutes in a gradient mode at a flow rate of 300 μL/min using a Hypersyl Gold PFP column (100 × 2.1 mm i.d., 1.9 μm) maintained at 30°C. Compounds were detected in positive ionization and MRM modes using a TSQ Endura mass spectrometer (ThermoFisher). The method was validated according to EMA guidelines. The LLOQ was in the range 1–50 pg/mg, and the calibration ranged from the LLOQ‐1000 pg/mg. Intra‐ and inter‐day accuracy (bias) and precision were < 15%. Extraction recoveries of parent drugs and metabolites were 74–120% and 7–62%, respectively. The matrix effect was in the range 59–126% (CVs ≤ 12.9%). Fentanyl was found in six cases at concentrations of < 1–1650 pg/mg (n = 14 segments). Five fentanyl analogs were quantified in two cases: 3‐fluorofentanyl (25–150 pg/mg, n = 5), furanylfentanyl (15–500 pg/mg, n = 5), methoxyacetylfentanyl (500–600 pg/mg, n = 2), acetylfentanyl (1 pg/mg, n = 2), carfentanyl (2.5–3 pg/mg, n = 2). This fully validated method allowed us to test for the first time 3‐fluorofentanyl and norcarfentanil in hair among 15 other NSOs, and brings new data regarding 3‐fluorofentanyl and methoxyacetylfentanyl hair concentrations.
Can interbasin water transfer affect water consumption and pollution? Lessons from China's South–North water transfer project
Authors: Sheng Jichuan , Tang Weizong , Webber Michael 
Published: June 2020

AbstractInterbasin water transfer has become a means by which countries around the world solve the problem of water shortage. Moreover, interbasin water transfers may also stimulate stronger controls over water pollution control in water‐receiving areas. However, most existing literature fails to examine the impacts of interbasin water transfers on water consumption and pollution from the perspective of the complex entanglement between human activities and environmental change. In order to respond to this research gap, this study establishes an improved human–environment model that considers the impacts of interbasin water transfer, and uses data about China's South–North Water Transfer Project to empirically study the temporal and spatial effects of interbasin water transfers. The results show that interbasin water transfer not only fails to improve water consumption in water‐receiving cities but also further restricts residents' water use due to the high water price caused by this project. Furthermore, interbasin water transfers also fail to reduce water pollution in water‐receiving cities—levels of water pollution depend more on external environmental policies. These results have some implications for understanding the interbasin water transfers in authoritarian states: although interbasin water transfers do not affect water consumption and pollution, authoritarian states can maintain and consolidate their political legitimacy by gaining public trust through interbasin water transfers.
Digital health care solution for proactive heart failure management with the Cordella Heart Failure System: results of the SIRONA first‐in‐human study
Authors: Mullens Wilfried , Sharif Faisal , Dupont Matthias , Rothman Alexander M.K. , Wijns William 
Published: June 2020

AbstractAimsIncorporation of remote monitoring of pulmonary artery pressure and vital signs has been demonstrated to reduce heart failure (HF) hospitalization and all‐cause mortality in selected symptomatic HF patients. The aim of this study is to investigate the safety and accuracy of the new CordellaTM Pulmonary Artery Pressure Sensor (Endotronix, Inc., Chicago, IL, USA) and the usability of the comprehensive CordellaTM Heart Failure System (CHFS).Methods and resultsMulticentre, open‐label, first‐in‐human, feasibility study to evaluate the CHFS and the safety and accuracy of the Cordella™ Pulmonary Artery Pressure Sensor in 15 patients with New York Heart Association class III HF. All patients were successfully implanted with the Cordella Pulmonary Artery Pressure Sensor, without sensor failure. No device system‐related complications, defined as invasive treatment, device explant or death, occurred. The primary efficacy endpoint of a mean pulmonary artery pressure at 90 days was met in all but one patients with a cohort difference of 2.7 mmHg (Cordella Sensor 22.5 ± 11.8 mmHg, Swan–Ganz catheter 25.2 ± 8.5 mmHg). One patient did not go through the 90‐day right heart catheterization for safety reasons. Patient adherence to daily measurement, transmission of vital signs and pulmonary artery pressure sensor readings were recorded 99% of the time.ConclusionThe initial experience of the CHFS incorporating comprehensive vital signs and pulmonary artery pressure monitoring enables safe and accurate monitoring of HF status.
The impact of COVID‐19 on heart failure hospitalization and management: report from a Heart Failure Unit in London during the peak of the pandemic
Authors: Bromage Daniel I. , Cannatà Antonio , Rind Irfan A. , Gregorio Caterina , Piper Susan , Shah Ajay M. , McDonagh Theresa A. 
Published: June 2020

AimsTo examine the impact of COVID‐19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and management of patients admitted to a tertiary Heart Failure Unit in London during the peak of the pandemic.Methods and resultsData from King's College Hospital, London, reported to the National Heart Failure Audit for England and Wales, between 2 March–19 April 2020 were compared both to a pre‐COVID cohort and the corresponding time periods in 2017 to 2019 with respect to absolute hospitalization rates. Furthermore, we performed detailed comparison of patients hospitalized during the COVID‐19 pandemic and patients presenting in the same period in 2019 with respect to clinical characteristics and management during the index admission. A significantly lower admission rate for AHF was observed during the study period compared to all other included time periods. Patients admitted during the COVID‐19 pandemic had higher rates of New York Heart Association III or IV symptoms (96% vs. 77%, P = 0.03) and severe peripheral oedema (39% vs. 14%, P = 0.01). We did not observe any differences in inpatient management, including place of care and pharmacological management of heart failure with reduced ejection fraction.ConclusionIncident AHF hospitalization significantly declined in our centre during the COVID‐19 pandemic, but hospitalized patients had more severe symptoms at admission. Further studies are needed to investigate whether the incidence of AHF declined or patients did not present to hospital while the national lockdown and social distancing restrictions were in place. From a public health perspective, it is imperative to ascertain whether this will be associated with worse long‐term outcomes.
Bidirectional resource scheduling algorithm for advanced long term evolution system
Authors: Gatti Ravi , Shankar Shiva 
Published: June 2020

AbstractThe 5G long term evolution‐advanced (LTE‐A) system aims to offer unprecedent data rates, user experience, and minimal latency amongst the end users with the introduction of carrier aggregation (CA) technology. Radio resource management (RRM) with scheduler is responsible for satisfying the user quality of service (QoS) requirements through resource allocation. Due to the need for an uninterrupted bidirectional communication between the eNodeB and user equipment (UE) in LTE‐A, the joint scheduling algorithm is acknowledged as a central research prospect. In this article, a modified joint uplink/downlink (UL/DL) user carrier scheduling algorithm satisfying demand service requests UE, is proposed. The joint optimization of the subcarrier assignment in an orthogonal frequency‐division multiplexing‐based network is utilized to balance the resource coupling between the UL/DL directions. CA is used to determine the weight factors required for the bandwidth allocation within the mobile users based on the QoS class identifier. These weight factors are employed as probability functions for resource allocation. The proposed algorithm will reduce the computational complexity arised in the conventional joint UL/DL scheduling algorithm based on the suboptimal solutions via probability functions. The simulation results show that the packet loss rate and packet delay among the mobile users are substantially reduced for both real‐time and nonreal‐time services.
Protective effects of cyanidin‐3‐O‐glucoside on UVB‐induced chronic skin photodamage in mice via alleviating oxidative damage and anti‐inflammation
Authors: Peng Ziyao , Hu Xiaolong , Li Xusheng , Jiang Xinwei , Deng Liehua , Hu Yunfeng , Bai Weibin 
Published: June 2020

AbstractExcessive ultraviolet (UV) radiation exposure results in skin chronic photodamage via stimulating reactive oxygen species (ROS) and inflammation. Anthocyanins are a group of flavonoids frequently found in edible plants. Cyanidin‐3‐O‐glucoside (C3G) as a typical anthocyanin shows effective anti‐oxidative and anti‐inflammatory properties. This study aims to investigate whether the topical application of C3G moisturizing gel on mice can protect the skin from UVB‐induced chronic photodamage. The results of in vitro experiment showed that the active ingredient C3G can penetrate the mice skin. The dorsal of Kunming mice were treated with C3G moisturizing gel (100, 200, 300 μmol/L) after UVB exposure. The animal experiment demonstrated that C3G can reduce chronic photodamage caused by UVB. C3G could effectively ameliorate the UVB‐induced epidermal barrier dysfunction including an increase in the skin hydration and decrease in the transepidermal water loss, and have statistically significance. Besides, our results also indicated that C3G inhibited UVB‐induced epidermal hyperplasia, the destruction of collagen fibers, ROS levels, and the expression of COX‐2 and IL‐6. In brief, these results indicate that C3G can reduce UVB‐induced chronic photodamage by inhibiting oxidative stress and inflammation.
Clinical and surgical management of patients with head and neck cancer in a COVID‐19 dedicated center in Italy
Authors: Galli Jacopo , Settimi Stefano , Tricarico Laura , Almadori Giovanni , Paludetti Gaetano 
Published: June 2020

AbstractIntroductionFor the EARs NOSE AND THROAT (ENT) surgeon, there are many challenges that show‐up in the clinical management of a patient affected by a head and neck cancer during COVID‐19 pandemic, especially in the postoperative period.MethodsDuring the acute COVID‐19 emergency phase in Italy, we analyzed the management of a patient affected by a head and neck cancer. We reported several clinical data about the hospitalization period, pointing out the difficulties encountered both from clinical and management point of view.ResultsDuring pandemic, we admitted 27 oncological patients at our ENT Department. Delays in surgical procedures, complications of hospitalizations, need for radiological studies, and possible transfer to other hospital ward, due to suspect SARS‐CoV‐2 infection, were registered.ConclusionsThe changes in the whole health care system during the COVID‐19 pandemic have impacted the management of patients with head and neck cancer, generating several clinical challenges for the ENT surgeon.