bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stunting: an overlooked problem in Myanmar – an economic evaluation
Authors: Aye San Kyu Kyu , Mar Swe Le , Lwin Nyi Nyi , Hnin Zar Lwin , Hlaing Lwin Mar , Washington Michael L. , Harris Julie R. 
Published: January 2020

AbstractObjectivesStunting increases a child's susceptibility to diseases, increases mortality, and is associated over long term with reduced cognitive abilities, educational achievement, and productivity. We aimed to assess the most effective public health nutritional intervention to reduce stunting in Myanmar.MethodsWe searched the literature and developed a conceptual framework for interventions known to reduce stunting. We focused on the highest impact and most feasible interventions to reduce stunting in Myanmar, described policies to implement them, and compared their costs and projected effect on stunting using data-based decision trees. We estimated costs from the government perspective and calculated total projected cases of stunting prevented and cost per case prevented (cost-effectiveness). All interventions were compared to projected cases of stunting resulting from the current situation (e.g., no additional interventions).ResultsThree new policy options were identified. Operational feasibility for all three options ranged from medium to high. Compared to the current situation, two were similarly cost-effective, at an additional USD 598 and USD 667 per case of stunting averted. The third option was much less cost-effective, at an additional USD 27,741 per case averted. However, if donor agencies were to expand their support in option three to the entire country, the prevalence of 22.5 percent would be reached by 2025 at an additional USD 667 per case averted.ConclusionsA policy option involving immediate expansion of the current implementation of proven nutrition-specific interventions is feasible. It would have the highest impact on stunting and would approach the WHO 2025 target.
Alin: improving interactive ontology matching by interactively revising mapping suggestions
Authors: Da Silva Jomar , Revoredo Kate , Baião Fernanda , Euzenat Jérôme 
Published: January 2020

Abstract
Ontology matching aims at discovering mappings between the entities of two ontologies. It plays an important role in the integration of heterogeneous data sources that are described by ontologies. Interactive ontology matching involves domain experts in the matching process. In some approaches, the expert provides feedback about mappings between ontology entities, that is, these approaches select mappings to present to the expert who replies which of them should be accepted or rejected, so taking advantage of the knowledge of domain experts towards finding an alignment. In this paper, we present Alin, an interactive ontology matching approach which uses expert feedback not only to approve or reject selected mappings but also to dynamically improve the set of selected mappings, that is, to interactively include and to exclude mappings from it. This additional use for expert answers aims at increasing in the benefit brought by each expert answer. For this purpose, Alin uses four techniques. Two techniques were used in the previous versions of Alin to dynamically select concept and attribute mappings. Two new techniques are introduced in this paper: one to dynamically select relationship mappings and another one to dynamically reject inconsistent selected mappings using anti-patterns. We compared Alin with state-of-the-art tools, showing that it generates alignment of comparable quality.
EQUILIBRIUM VALUATION OF CURRENCY OPTIONS UNDER A DISCONTINUOUS MODEL WITH CO-JUMPS
Authors: Xing Yu , Xu Yuhua , Niu Huawei 
Published: January 2020

AbstractIn this paper, we study the equilibrium valuation for currency options in a setting of the two-country Lucas-type economy. Different from the continuous model in Bakshi and Chen [1], we propose a discontinuous model with jump processes. Empirical findings reveal that the jump components in each country's money supply can be decomposed into the simultaneous co-jump component and the country-specific jump component. Each of the jump components is modeled with a Poisson process whose jump intensity follows a mean reversion stochastic process. By solving a partial integro-differential equation (PIDE), we get a closed-form solution to the PIDE for a European call currency option. The numerical results show that the derived option pricing formula is efficient for practical use. Importantly, we find that the co-jump has a significant impact on option price and implied volatility.
Process of therapeutic changes in Meaning-Centered Group Psychotherapy adapted to the Portuguese language: A narrative analysis
Authors: da Ponte Guida , Ouakinin Sílvia , Santo Jorge Espírito , Amorim Inês , Gameiro Zita , Fitz-Henley Mindi , Breitbart William 
Published: January 2020

AbstractObjectiveThe aim was to understand the processes of therapeutic changes in Meaning-Centered Group Psychotherapy (MCGP) in a Portuguese sample.MethodAdult cancer patients with distress motivated to participate in MCGP were identified; descriptive and narrative analyses were performed on the session content.ResultsThe sample had 24 participants (mean age: 63.43 years); the majority were females (75%), with a median academic degree (54%). Breast cancer was most frequent (67%) at the localized stage (71%). The narrative analysis defined seven categories according to the MCGP themes. In “Moments with Meaning (MwM),” the most relevant dimensions were related to interpersonal relations, the moment of diagnosis, and personal achievements. This category established relations with almost all other categories, as did the category “historical sources of meaning (SoM).” The category “identity before and after cancer diagnosis” was only related to “attitudinal SoM” and “transitions.” Historical SoM had two dimensions, “past” and “present and future” legacies, in which prominent topics related to family, childhood, achieved goals, and values to pass to others explored. Attitudinal SoM established relations only with the category “creative SoM,” in which “courage” and “responsibility” were the main dimensions, which were also related to “MwM,” “historical,” and “attitudinal SoM.” Experiential SoM, with the main dimension “love,” was related to “MwM” and “historical SoM.” Transitions only established relations with “historical SoM” and “identity before and after cancer.”Significance of resultsThe findings that “MwM” and “historical SoM” were the categories which established a solid pattern of relations suggest that these are the main psychotherapy topics that can have more influence for the participants; one explanation is that these categories imply a concrete way of thinking, which is easier to understand. This process of therapeutic changes must be integrated in a cultural context, as it is well known to have an impact upon the “meaning” of life.
Reassessing the dependence of capitalism on democracy – the case of Imperial Germany and the Weimar Republic
Authors: Wegner Gerhard 
Published: January 2020

AbstractThe paper interrogates the argument put forward by Acemoglu and Robinson or Northet al.that capitalism and democracy are supportive to each other. It analyzes the development of political and economic institutions in Germany before and after World War I. It is shown that the lack of democracy in Imperial Germany furthered a liberal economic order and gives reasons why the transition to full-scale parliamentarianism would have impaired the quality of economic institutions. This also explains why such a transition was not completed. The Weimar Republic established a modern democracy but was unable to secure the quality of economic institutions achieved before. Not only in Germany did the politicization of the economy impair the economic order. This empirical outcome helps to explain why Eucken and other liberals identified democracy as part of the economic problem during the interwar period. It also gives reasons to rethink the complex relationship between capitalism and democracy.
Qualitative research methods for institutional analysis
Authors: Skarbek David 
Published: January 2020

AbstractHow can economists use qualitative evidence – such as archival materials, interviews, and ethnography – to study institutions? While applied economists typically rely on quantitative evidence and statistical estimation, many important aspects of institutions and institutional change appear in the form of qualitative evidence. This raises the question if, and how, social scientists trained in quantitative methods can exploit and analyze this evidence. This paper discusses two qualitative research methods that are both commonly used outside of economics: comparative case studies and process tracing. Drawing on existing research about crime and political revolutions, it discusses these two methods and how to implement them to improve institutional analysis.
“The Forests Cannot Be Commons”
Authors: Woolley Christopher 
Published: January 2020

AbstractThis article examines the sylvan political ecology of late colonial New Spain and the colonial government's attempt to address deforestation through the Council on Forests, the first body in the kingdom's history dedicated to the conservation of natural resources. Drawing primarily from the corpus of documents produced by and remitted to the council, this article gives a trans-regional perspective on colonial forest use and argues that the Spanish crown's usurpation of indigenous communities’ eminent domain over forests was the first step in a process that over centuries progressively severed the cultural ties that bound communities and forests by converting common-pool resources into open-access commons. The catastrophic mortality of the Spanish invasion was the second step, which rendered conservation measures seemingly unnecessary among both woodcutters and officials. But it was during the eighteenth century that older Habsburg notions of protectionism intersected with economic and political changes associated with Bourbon rule to further compel this cultural severance. While previous works have studied the ecological impacts of mining, ranching, and flood control, this article moves beyond the study of a single industry to suggest some of the larger ecological consequences of Spanish colonialism.
Locating the Filipino as Malay: A Reassertion of Historical Identity from the Regional Periphery
Authors: Gomez José Edgardo Abaya 
Published: January 2020

AbstractIn Malaysia, Brunei, Singapore, and Indonesia, being Malay usually means being a practitioner of Islam and a speaker of standard Bahasa. However, such understandings no longer comprehend other members of the so-called brown-skinned race who were once united with the Malay aggrupation: numerous Filipinos (and East Timorese), who inhabit the same broad geopolitical region. Challenging the recent narrowly defined conceptions of who is, or was Malay, this study recalls an inclusive borderless understanding acquired in antiquity by the Filipino nation, whose peoples were considered by Spanish and American colonisers and educated by their government to consider themselves as part of a pre-modern “Malay” world. Geohistorical evidence shows how such auto-consciousness evolved and preceded the entry of the term into the nearby British colonisers’ lexicon, before its social-reconstruction for the perpetuation of post-colonial polities as well. The author interweaves his textual survey with the problematisation of the location of ethnicity, and points out the seemingly neglected corpus of Iberian works that demonstrate how the knowledge of Malayness could only have been approached by Europeans from a geographic periphery, of which the Philippine archipelago was very much a part, especially the Mindanao area. The author builds on and constructively critiques work by one scholar who had initiated the claims of the Filipino to Malayness. It is shown how sociocultural and geopolitical priorities can help or hinder the relaxation of definitions of who is Malay and where Malays are properly situated, if only because these counter perceptual rigidities, and allow the creation of hybrid third spaces that admit new possibilities of coexistence.
Potential yield loss in grain sorghum (Sorghum bicolor) with weed interference in the United States
Authors: Dille J. Anita , Stahlman Phillip W. , Thompson Curtis R. , Bean Brent W. , Soltani Nader , Sikkema Peter H. 
Published: January 2020

AbstractPotential yield losses in grain sorghum due to weed interference based on quantitative data from the major grain sorghum-growing areas of the United States are reported by the WSSA Weed Loss Committee. Weed scientists and extension specialists who researched weed control in grain sorghum provided data on grain sorghum yield loss due to weed interference in their region. Data were requested from up to 10 individual experiments per calendar year over 10 yr between 2007 and 2016. Based on the summarized information, farmers in Arkansas, Kansas, Missouri, Nebraska, South Dakota, and Texas would potentially lose an average of 37%, 38%, 30%, 56%, 61%, and 60% of their grain sorghum yield with no weed control, and have a corresponding annual monetary loss of US $19 million, 302 million, 7 million, 32 million, 25 million, and 314 million, respectively. The overall average yield loss due to weed interference was estimated to be 47% for this grain sorghum-growing region. Thus, US farmers would lose approximately 5,700 million kg of grain sorghum valued at approximately US $953 million annually if weeds are not controlled. With each dollar invested in weed management (based on estimated weed control cost of US $100 ha−1), there would be a return of US $3.80, highlighting the return on investment in weed management and the importance of continued weed science research for sustaining high grain sorghum yield and profitability in the United States.
The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer
Authors: Xu Pei , Xiao Haibo , Yang Qi , Hu Rui , Jiang Lianyong , Bi Rui , Jiang Xueyan , Wang Lei , Mei Ju , Ding Fangbao , Huang Jianbing 
Published: January 2020

AbstractDeubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in non-small-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR-4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.
BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner
Authors: Jeong Suji , An Borim , Kim Jung-Hyun , Han Hyo-Won , Kim Jung-Hyun , Heo Hye-Ryeon , Ha Kwon-Soo , Han Eun-Taek , Park Won Sun , Hong Seok-Ho 
Published: January 2020

AbstractThe efficient and reproducible derivation and maturation of multipotent hematopoietic progenitors from human pluripotent stem cells (hPSCs) requires the recapitulation of appropriate developmental stages and the microenvironment. Here, using serum-, xeno-, and feeder-free stepwise hematopoietic induction protocols, we showed that short-term and high-concentration treatment of hPSCs with bone morphogenetic protein 4 (BMP4) strongly promoted early mesoderm induction followed by increased hematopoietic commitment. This method reduced variations in hematopoietic differentiation among hPSC lines maintained under chemically defined Essential 8 medium compared to those maintained under less-defined mTeSR medium. We also found that perivascular niche cells (PVCs) significantly augmented the production of hematopoietic cells via paracrine signaling mechanisms only when they were present during the hematopoietic commitment phase. A protein array revealed 86 differentially expressed (>1.5-fold) secretion factors in PVC-conditioned medium compared with serum-free control medium, of which the transforming growth factor-β inducible gene H3 significantly increased the number of hematopoietic colony-forming colonies. Our data suggest that BMP4 and PVCs promote the hematopoietic differentiation of hPSCs in a differentiation stage-specific manner. This will increase our understanding of hematopoietic development and expedite the development of hPSC-derived blood products for therapeutic use.
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
Authors: Park Hye-Kyung , Yoon Nam Gu , Lee Ji-Eun , Hu Sung , Yoon Sora , Kim So Yeon , Hong Jun-Hee , Nam Dougu , Chae Young Chan , Park Jong Bae , Kang Byoung Heon 
Published: January 2020

AbstractThe Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reasonable strategy for cancer therapy. However, since the existing pan-Hsp90 inhibitor does not accumulate in mitochondria, the potential anticancer activity of pan-Hsp90 inhibition has not yet been fully examined in vivo. Analysis of The Cancer Genome Atlas database revealed that all Hsp90 paralogs were upregulated in prostate cancer. Inactivation of all Hsp90 paralogs induced mitochondrial dysfunction, increased cytosolic calcium, and activated calcineurin. Active calcineurin blocked prosurvival heat shock responses upon Hsp90 inhibition by preventing nuclear translocation of HSF1. The purine scaffold derivative DN401 inhibited all Hsp90 paralogs simultaneously and showed stronger anticancer activity than other Hsp90 inhibitors. Pan-Hsp90 inhibition increased cytotoxicity and suppressed mechanisms that protect cancer cells, suggesting that it is a feasible strategy for the development of potent anticancer drugs. The mitochondria-permeable drug DN401 is a newly identified in vivo pan-Hsp90 inhibitor with potent anticancer activity.
Role of interleukin-23 in the development of nonallergic eosinophilic inflammation in a murine model of asthma
Authors: Lee Hyun Seung , Park Da-Eun , Lee Ji-Won , Sohn Kyung Hee , Cho Sang-Heon , Park Heung-Woo 
Published: January 2020

AbstractNonallergic eosinophilic asthma (NAEA) is a clinically distinct subtype of asthma. Thus far, the pathophysiologic mechanisms underlying NAEA have not been fully elucidated. This study aimed to determine the role of IL-23 in the pathogenesis of NAEA. We developed a murine model of NAEA using recombinant IL-23 (rIL-23) plus a nonspecific airway irritant [polyinosinic-polycytidylic acid (polyI:C) or diesel exhaust particles (DEPs)] and investigated whether IL-23 plays an important role in the development of NAEA. Intranasal administration of rIL-23 (0.1 μg/mouse) plus polyI:C (0.01 μg/mouse) or DEPs (10 μg/mouse) without allergen resulted in methacholine bronchial hyperresponsiveness and eosinophilic airway inflammation in mice, which are characteristic features of NAEA. rIL-23 plus a low dose nonspecific airway irritants induced the release of innate cytokines from airway epithelium, including IL-33, thymic stromal lymphopoietin and IL-1β; these factors activated types 2 and 3 innate lymphoid cells (ILC2s and ILC3s). ILC2s and ILC3s, but not CD4+ T cells (i.e., adaptive immune cells), were important in the development of NAEA. In addition, we observed that IL-23 receptor expressions increased in airway epithelial cells, which suggests the existence of a positive autocrine loop in our murine model of NAEA. To our knowledge, this is the first report in which administration of rIL-23 plus a nonspecific airway irritant (polyI:C or DEPs) without allergen resulted in features of NAEA in mice similar to those found in humans. IL-23 may constitute a therapeutic target for NAEA in humans.
Amino acid transporters as tetraspanin TM4SF5 binding partners
Authors: Jung Jae Woo , Kim Ji Eon , Kim Eunmi , Lee Jung Weon 
Published: January 2020

AbstractTransmembrane 4 L6 family member 5 (TM4SF5) is a tetraspanin that has four transmembrane domains and can be N-glycosylated and palmitoylated. These posttranslational modifications of TM4SF5 enable homophilic or heterophilic binding to diverse membrane proteins and receptors, including growth factor receptors, integrins, and tetraspanins. As a member of the tetraspanin family, TM4SF5 promotes protein-protein complexes for the spatiotemporal regulation of the expression, stability, binding, and signaling activity of its binding partners. Chronic diseases such as liver diseases involve bidirectional communication between extracellular and intracellular spaces, resulting in immune-related metabolic effects during the development of pathological phenotypes. It has recently been shown that, during the development of fibrosis and cancer, TM4SF5 forms protein-protein complexes with amino acid transporters, which can lead to the regulation of cystine uptake from the extracellular space to the cytosol and arginine export from the lysosomal lumen to the cytosol. Furthermore, using proteomic analyses, we found that diverse amino acid transporters were precipitated with TM4SF5, although these binding partners need to be confirmed by other approaches and in functionally relevant studies. This review discusses the scope of the pathological relevance of TM4SF5 and its binding to certain amino acid transporters.
Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array
Authors: Ren Yu-Xuan , Wu Jianglai , Lai Queenie T. K. , Lai Hei Ming , Siu Dickson M. D. , Wu Wutian , Wong Kenneth K. Y. , Tsia Kevin K. 
Published: January 2020

AbstractParallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional (3D) visualization of dynamical biological processes with minimal photodamage. However, the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three dimensions. We hereby develop a novel fluorescence imaging approach, called coded light-sheet array microscopy (CLAM), which allows complete parallelized 3D imaging without mechanical scanning. Harnessing the concept of an “infinity mirror”, CLAM generates a light-sheet array with controllable sheet density and degree of coherence. Thus, CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/scanning. Moreover, the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged volume. We demonstrate the utility of CLAM in different imaging scenarios, including a light-scattering medium, an optically cleared tissue, and microparticles in fluidic flow. CLAM can maximize the signal-to-noise ratio and the spatial duty cycle, and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging systems. The flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research.