bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESÚMENES DE TRABAJOS FINALES INTEGRADORES: ESPECIALIZACIÓN EN VINCULACIÓN Y GESTIÓN TECNOLÓGICA
Authors: Collins Pablo Agustín 
Published: May 2020

Redes de cooperación e innovación: el caso de las Pequeñas y Medianas Empresas Metalmecánicas de la Microrregión Crespo y Aldeas Aledañas – MiCrAMaría José Haberkorn - mariajosehaberkorn@gmail.comDirectora: Dra. María Valentina LocherCo-Director: Dr. Ignacio Tomás TruccoFecha de defensa: 21 de noviembre de 2018

Proyecto para la implementación de la preincubadora de empresas del Polo Tecnológico ReconquistaPablo Daniel Longhi -- pablo.d.longhi@gmail.comDirector: Lic. Julio TealdoFecha de defensa: 6 de junio de 2018
The European Biological Variation Study (EuBIVAS): weekly biological variation of cardiac troponin I estimated by the use of two different high-sensitivity cardiac troponin I assays
Authors: Ceriotti Ferruccio , Díaz-Garzón Marco Jorge , Fernández-Calle Pilar , Maregnani Alessio , Aarsand Aasne K. , Coskun Abdurrahman , Jonker Niels , Sandberg Sverre , Carobene Anna 
Published: May 2020

Abstract

Background
Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation of biological variation (BV) of cTn. The knowledge of BV is important to define analytical performance specifications (APS) and reference change values (RCVs). The aim of this study was to estimate the within- and between-subject weekly BV (CVI, CVG) of cTnI applying two high-sensitivity cTnI assays, using European Biological Variation Study (EuBIVAS) specimens.

Methods
Thirty-eight men and 53 women underwent weekly fasting blood drawings for 10 consecutive weeks. Duplicate measurements were performed with Singulex Clarity (Singulex, USA) and Siemens Atellica (Siemens Healthineers, Germany).

Results
cTnI was measurable in 99.4% and 74.3% of the samples with Singulex and Atellica assays, respectively. Concentrations were significantly higher in men than in women with both methods. The CVI estimates with 95% confidence interval (CI) were for Singulex 16.6% (15.6–17.7) and for Atellica 13.8% (12.7–15.0), with the observed difference likely being caused by the different number of measurable samples. No significant CVI differences were observed between men and women. The CVG estimates for women were 40.3% and 36.3%, and for men 65.3% and 36.5% for Singulex and Atellica, respectively. The resulting APS and RCVs were similar for the two methods.

Conclusions
This is the first study able to estimate cTnI BV for such a large cohort of well-characterized healthy individuals deriving objective APS and RCV values for detecting significant variations in cTnI serial measurements, even within the 99th percentile.
Performance of a Toxo IgM prototype assay for the diagnosis of maternal and congenital Toxoplasma infections
Authors: Wallon Martine , Fricker-Hidalgo Hélène , Chapey Emmanuelle , Bailet Claire , Dard Céline , Brenier-Pinchart Marie-Pierre , Pelloux Hervé 
Published: May 2020

Abstract

Background
Testing for anti-Toxoplasma immunoglobulin (Ig)M is of main importance in the context of pregnancy to promptly alert to an acute maternal infection prior to the detection of IgG and to identify infected newborns. Their absence helps exclude a recent maternal infection in the presence of IgG.

Methods
The performance of a Toxo IgM immunocapture prototype assay (bioMérieux, France) was compared with that of the VIDAS® Toxo IgM and the ARCHITECT® Toxo IgM (Abbott, Germany) assays at Grenoble and Lyon (France). A total of 1446 sera were sampled from (i) 1054 pregnant women found by routine workup to have no infection (n = 843), an acute infection (<4 months) (n = 28) or a chronic infection (>4 months) with residual (n = 120) or no IgM (n = 62); (ii) 50 three-serum panels sampled immediately after a maternal seroconversion; (iii) 242 samples taken in 41 children with a congenital toxoplasmosis (n = 122) and in 40 uninfected children (n = 120).

Results
In pregnant women, the overall agreement with the VIDAS® assay was 99.23% (CI: 99.16–99.27) and that with the ARCHITECT® assay was 99.14% (CI: 99.07–99.17). Sensitivity of the Toxo IgM prototype assay was 100% (CI: 87.66–100.00) and specificity was 99.64% (98.96–99.93). In acute maternal infections, IgM assays were detected as early with the prototype as with the other two. In the congenitally infected children, IgM were detected on their first sample in 25/40 with the prototype vs. 23/40 with the VIDAS® test. No uninfected child had positive IgM.

Conclusion
The prototype performed comparably to the ARCHITECT® and VIDAS® Toxo IgM assays for the diagnosis of maternal and congenital toxoplasmosis.
Assignment of international normalized ratio to frozen and freeze-dried pooled plasmas
Authors: van den Besselaar Antonius M.H.P. , Cobbaert Christa M. 
Published: May 2020

Abstract

Objectives
Frozen and freeze-dried plasmas may be used for local prothrombin time system calibration, for direct international normalized ratio (INR) determination, and for quality assessment. The purpose of the present study was to evaluate the usefulness of INRs assigned with various types of thromboplastins to frozen and freeze-dried pooled plasmas obtained from patients treated with vitamin K antagonists.

Methods
INRs were calculated according to the international sensitivity index (ISI) model using various thromboplastins and instruments, i.e. International Standards for thromboplastin as well as six commercial reagents prepared from rabbit and bovine brain, and recombinant human tissue factor. The uncertainty of the INRs was assessed using the standard deviations of clotting times and ISI values. Commutability of the plasmas was assessed according to the approved Clinical and Laboratory Standards Institute (CLSI) Guideline EP30-A. Validation of a set of six frozen plasma pools for direct INR determination was performed according to the Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (SSC/ISTH) guidelines.

Results
For all frozen and freeze-dried plasmas, the INRs calculated with bovine thromboplastin Thrombotest were lower than the INRs assigned with other thromboplastins. With a few exceptions, the frozen and freeze-dried pooled plasmas were commutable. When the set of six frozen plasma pools was used for local calibration, the analytical bias of the INR was less than ±10% for all commercial reagents except Thrombotest.

Conclusions
Processing of fresh plasmas to prepare pooled frozen plasmas and freeze-dried plasmas may lead to different INR assignments depending on the thromboplastin used. Despite minor INR differences, a set of six frozen plasma pools could be used for local calibration by direct INR determination.
Current state of the morphological assessment of urinary erythrocytes in The Netherlands: a nation-wide questionnaire
Authors: Luimstra Jolien J. , Koçer Rüya G. , Jerman Alexander , Klein Gunnewiek Jacqueline , Gijzen Karlijn , Jacobs Leo H.J. , Demir Ayşe Y. 
Published: May 2020

Abstract

Background
The morphological assessment of urinary erythrocytes (uRBC) is a convenient screening tool for the differentiation of nephrological (dysmorphic) and urological (isomorphic) causes of hematuria. Considering the morphological heterogeneity, this analysis is often perceived as difficult. There is no clear (inter)national consensus and there is a lack of external quality assessment programs. To gain insight into the heterogeneity within and between laboratories, we scrutinized the current state of this analysis in Dutch medical laboratories.

Methods
The laboratories, affiliated with the Dutch Foundation for Quality Assessment in Medical Laboratories, were invited to participate in a web-based survey, consisting of two questionnaires. The first one provided information about the institution and laboratory organization, and the second explored the variability in the morphological analysis of uRBC on the basis of categorization of 160 uRBC images. Statistical analysis was premised on binomial significance testing and principal component analysis.

Results
Nearly one third of the Dutch medical laboratories (65/191) with 167 staff members participated in the survey. Most of these laboratories (83%) were an integral part of secondary care. The statistical analysis of the evaluations of the participants in comparison to the consensus (three experts from two different medical laboratories) suggested a great degree of heterogeneity in the agreement. Nearly half of the participants consciously disagreed with the consensus, whereas one fifth demonstrated a random relationship with it.

Conclusions
In Dutch medical laboratories, results from morphological analysis of uRBC are heterogeneous, which point out the necessity for standardization and harmonization.
The Linguistic Effects of Context Specificity: Exploring Affect, Cognitive Processing, and Agency in Physicians’ Think-Aloud Reflections
Authors: Konopasky Abigail , Durning Steven J. , Artino Anthony R. , Ramani Divya , Battista Alexis 
Published: May 2020

Abstract

Background
The literature suggests that affect, higher-level cognitive processes (e.g. decision-making), and agency (the capacity to produce an effect) are important for reasoning; however, we do not know how these factors respond to context. Using situated cognition theory as a framework, and linguistic tools as a method, we explored the effects of context specificity [a physician seeing two patients with identical presentations (symptoms and findings), but coming to two different diagnoses], hypothesizing more linguistic markers of cognitive load in the presence of contextual factors (e.g. incorrect diagnostic suggestion).

Methods
In this comparative and exploratory study, 64 physicians each completed one case with contextual factors and one without. Transcribed think-aloud reflections were coded by Linguistic Inquiry and Word Count (LIWC) software for markers of affect, cognitive processes, and first-person pronouns. A repeated-measures multivariate analysis of variance was used to inferentially compare these LIWC categories between cases with and without contextual factors. This was followed by exploratory descriptive analysis of subcategories.

Results
As hypothesized, participants used more affective and cognitive process markers in cases with contextual factors and more I/me pronouns in cases without. These differences were statistically significant for cognitive processing words but not affective and pronominal words. Exploratory analysis revealed more negative emotions, cognitive processes of insight, and third-person pronouns in cases with contextual factors.

Conclusions
This study exposes linguistic differences arising from context specificity. These results demonstrate the value of a situated cognition view of patient encounters and reveal the utility of linguistic tools for examining clinical reasoning.
Political Identity and Citizenship Participation (Representatives) in Politics by Minangkabau Women in Post-2019 Election
Authors: Chairiyah Sri Zul 
Published: May 2020

This research aimed to describe the identity politics and citizenship of Minangkabau women, towards the political participation (representation) of Minangkabau women in the post-2019 election. Minangkabau women have 2 identities, in adat (matrilineal system) women have rights that are equal to men in decision making, while in religion (patrilineal system), women are not one of the main elements in decision making. In citizenship, community still applies a patriarchal culture that is rooted and dominates. These two identities have a major influence on the political representation of Minangkabau women, where identity politics and citizenship are attempts to understand the relationship of these two concepts to the involvement of Minangkabau women in political representation in each election. The research used aqualitative method with individual analysis. This research was conducted in West Sumatra Province. These two factors influence the political representation of Minangkabau women in West Sumatra. The temporary conclusion showed that the low political representation of Minangkabau women in legislative institutions is not because of identity politics but because of patriarchal culture is still rooted and dominates in the community especially in West Sumatra.
Democratic Challenge in Digital Era
Authors: Handoyo Eko 
Published: May 2020

This article is based on the growing development of social media in the digital era which provides new public spaces for citizens to express themselves and their interactions with fellow citizens in various aspects of life. This article used library research method to answer the changes from procedural democracy to substantial democracy and the way of democratic citizenship through social media. This article revealed that the use of social media is no longer limited to daily needs, however, social media has a significant role in building political culture as well as citizenship issues in society.
Immune Checkpoint Inhibitor-Associated Primary Adrenal Insufficiency: WHO VigiBase Report Analysis
Authors: Grouthier Virginie , Lebrun-Vignes Bénédicte , Moey Melissa , Johnson Douglas B. , Moslehi Javid J. , Salem Joe-Elie , Bachelot Anne 
Published: May 2020

Abstract

Background
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may also trigger autoimmune adverse drug reactions (ADRs) referred to as immune-related adverse events (irAEs). Although endocrinopathies are among the most common form of irAEs, primary adrenal insufficiency (PAI) is infrequent and has only been published in case reports. The aim of this study was to identify and characterize the main features of PAI-irAE.

Materials and Methods
Suspected PAI-irAE cases were identified using VigiBase, the World Health Organization's pharmacovigilance database of individual case safety reports.

Results
From September 2, 2008, through October 5, 2018, a total of 50,108 ICI-associated ADRs were reported. Since 2008, there were 451 cases of PAI-irAE identified of which 45 were “definite PAI” and 406 “possible PAI.” Patients were mainly male (58.1%) with a median age of 66 years (range, 30–95). Indications of ICI were predominantly for melanoma (41.2%) and lung cancer (28.6%). The majority of patients were treated with ICI monotherapy (nivolumab: 44.3%, pembrolizumab: 11.7%, ipilimumab: 23.6%), and 17.9% were treated with ICI combination therapy. These events occurred with a median time to onset of 120 days (range, 6–576). ICI-associated PAI was associated with significant morbidity (≥90% severe) and mortality (7.3%). Fatality rates were similar in the subgroups of combination therapy versus monotherapy. There were no relevant differences in clinical or demographical characteristics and outcomes between “definite” versus “possible” PAI group.

Conclusion
Our study represents the largest clinical description and characterization of PAI-irAE. Although ICI-associated PAI is a rare adverse event, early recognition is important to implement corticosteroid treatment. Further studies are required to elucidate risk factors and reversibility of this rare but severe irAE. Clinical trial identification number. NCT03492242

Implications for Practice
Immune checkpoint inhibitor (ICI)-associated primary adrenal insufficiency (PAI) is a rare adverse event that is important to recognize because it may be severe and life-threatening, requiring emergent and often lifelong hormonal replacement therapy. Awareness regarding this ICI-related endocrinopathy is strongly encouraged among clinicians in addition to patient education about common PAI symptoms that should prompt urgent medical evaluation. In clinical practice, close monitoring and investigation for PAI is crucial to allow for early management and to further define the pathophysiology and prognosis of ICI-PAI. Corticotrophin (adrenocorticotrophic hormone) circulating level evaluation may be often lacking but should be considered as part of the diagnostic workup to differentiate PAI from secondary (central) adrenal insufficiency.
Efficacy of Moxifloxacin plus Treatment of Physician's Choice in Patients with Metastatic Breast Cancer
Authors: Wang Xinyue , Li JiBin , Shi Wei , Huang Zhangzan , Xia Wen , Huang Jiajia , Su Yanhong , Wang Shusen , Shi Yanxia , Bi Xiwen , Yuan Zhongyu 
Published: May 2020

AbstractLessons LearnedMoxifloxacin plus continuation of the previous treatment of physician's choice shows promising efficacy in patients with metastatic breast cancer. The addition of moxifloxacin shows well-tolerated toxicities.BackgroundRecent studies have confirmed bacterial infection as an important contributor in cancer. Elimination of tumor-associated microbes may lead to a reduction in tumors and improved survival. Moxifloxacin is an orally administrated fourth-generation quinolone with broad-spectrum coverage against tumor-associated bacteria.MethodsIn this study, we assessed the efficacy and safety of moxifloxacin in combination with treatment of physician's choice (TPC) in patients with metastatic breast cancer (MBC). In this single-arm, phase II study, we recruited 30 patients with MBC who had a trend toward disease progression (stable disease [SD] with increased tumor size) during TPC before enrollment at Sun Yat-sen University Cancer Center between January 1 and July 30, 2018. Eligible patients were given moxifloxacin once daily at a dose of 400 mg from days 1 to 7 of a 28-day cycle, in addition to continuing to receive the therapy previously selected by their physicians. Tumor response was determined according to RECIST (version 1.1). Progression-free survival (PFS) was calculated using the Kaplan-Meier method.ResultsThe concomitant use of moxifloxacin and previous TPC yielded a median PFS of 6.6 months (95% confidence interval [CI]: 4.0–9.1) and a 1-year PFS of 25.9% (95% CI: 10.0%–41.9%). Objective responses were achieved in seven (23.3%, 95% CI: 7.3%–39.4%) patients. The clinical benefit rate was 46.7% (95% CI: 27.7%–65.6%). No grade 4 adverse events (AEs) and four grade 3 AEs were observed, none of which were considered to have definite relation to moxifloxacin.ConclusionThe combination of moxifloxacin with previous TPC shows promising efficacy and well-tolerated toxicities in patients with MBC.
Effect of intercropping madumbe (Colocasia esculenta) and rice (Oryza sativa L.) on yield and land productivity under different irrigation water management techniques with effluent water
Authors: TI Busari  , A Senzanje  , AO Odindo  , CA Buckley  
Published: May 2020

The need for the optimal use of land, without a yield penalty, in urban and peri-urban (UP) settlements is vital. This study investigated the effect of intercropping madumbe and rice with respect to yield and land productivity when irrigated with anaerobic baffled reactor (ABR) effluent under different irrigation water management techniques. It was hypothesized that intercropping under different irrigation water management techniques has no effect on the yield and land productivity. Field trials were conducted in the 2017 and 2018 cropping seasons with ABR effluent (without fertilizer) at the Newlands Mashu Experimental Site, Newlands East, Durban, South Africa. A randomized complete block design with 3 replications; cropping treatments of sole madumbe, sole rice and madumbe + rice (intercrop) and irrigation treatments of alternate wetting and drying (AWD), continuous flood irrigation (CFI) and wetting without flooding (WWF) was used. Growth and yield parameters at harvest were determined. Thereafter, land equivalent ratio (LER) was calculated to evaluate the productivity of the intercrop. The effect of intercropping was significant (P < 0.05) on the total number of irrigation events and total water use. There was a significant reduction (P < 0.05) in plant heights of both madumbe and rice at intercrop. However, the effect on plant height for treatment CFI was positive but not significant (P > 0.05) for both seasons. A significant (P < 0.05) reduction also occurred in the number of madumbe leaves/plant, and panicles/plant and tillers/plant for rice. Intercropping significantly reduced (P < 0.05) madumbe corm and rice grain yield over the two seasons relative to sole cropping. LER showed that intercropping madumbe with rice was not more productive (LER < 1) than sole cropping of madumbe. It was concluded that over the two-season period, intercropping madumbe and rice do not yield appreciably under any of the three irrigation management techniques applied and the study hypothesis is thus rejected.
PERCEPTION OF EDUCATED CITIZENS ON AADHAR CARD AS A TOOL FOR EFFICIENT E-GOVERNANCE IN INDIA - A CONCEPTUAL MODEL
Authors: Chavali Kavita , Mavuri Sudha 
Published: May 2020

Purpose of the study: The research study is an attempt made to understand the perception of residents on Aadhar card (Biometric identification) as a tool for E-Governance in India.
Methodology: For this study, purposive sampling is used and 400 samples are drawn from educated residents within India. The study has adopted Structural Equation Modeling through AMOS to test the hypotheses and build the conceptual model by using five indicators and 35 items.
Findings: The results reveal that only Reliability has a significant impact on the Efficiency of Aadhar card as an E-Governance tool. The study results indicate that Concern as a factor has a negative impact on Efficiency but statistically insignificant.
Implications of the study: The understanding of the perception of residents on Aadhar card as a tool for E-Governance is important for policymakers to bring in better governance and proper implementation of efficient Information and Communication Technologies (ICTs).
Novelty/Originality of the study: The study gives a unique insight into examining the perception of residents as to how efficient Aadhar card is as a tool for E-Governance.
Corangiomas en el Instituto Materno Infantil a propósito de un corangioma gigante
Authors: Romero Rojas Alfredo Ernesto , Sánchez Baracaldo Lilia María 
Published: May 2020

Presentamos los resultados de una serie de 6 corangiomas vistos en el Instituto Materno Infantil de Santafé de Bogotá, entre 1992 y 1999. La incidencia de corangiomas fue de 0.11%. Uno de los casos fue un corangioma gigante asociado a polihidramnios. Otras asociaciones que se encontraron a los corioangioma incluyeron retardo en el crecimiento intrauterino, pre-eclampsia y embarazo múltiple.
Más allá del principio de proporcionalidad
Authors: Ferreres Comella Víctor 
Published: May 2020

El presente artículo aborda el principio de proporcionalidad a la luz de una teoría sustantiva de la justicia y los derechos subjetivos que lo fundamenta. A pesar de la existencia del principio de proporcionalidad, resulta necesaria una teoría “externa” a la mecánica del funcionamiento del principio de proporcionalidad. Una que sirva de soporte a los jueces al momento de responder las preguntas normativas que exige la aplicación del principio. Los pasos y las probabilidades de la proporcionalidad no son suficientes a la hora de identificar distinciones cualitativas entre derechos o atribuir pesos abtractos a la restricción de un derecho vis-à-vis el cumplimiento de un fin legítimo o la garantía de otro derecho de igual importancia. Por tal razón, el presente artículo subraya la necesidad de elaborar serie de teorías sustantivas que sustenten el test de proporcionalidad al determinar, entre otros elementos, el alcance y la aplicación de los derechos en las diferentes esferas sociales, el efecto horizontal de los derechos constitucionales en el ámbito privado, o las implicaciones institucionales de la aplicación del principio de constitucionalidad al determinar el rol de los tribunales en ejercicio del control constitucional.