bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population‐based study of serum ferritin in early pregnancy and adverse perinatal outcomes
Authors: Ray Joel G. , Berger Howard , Park Alison L. 
Published: June 2020

AbstractBackgroundChronic placental inflammation is associated with preterm birth (PTB) and perinatal mortality. Ferritin is often elevated in chronic inflammatory conditions, but prior studies of its relation to PTB were restricted to ferritin measurement within pregnancy, were underpowered to detect rarer outcomes, and did not account for pre‐existing maternal inflammatory conditions, such as inflammatory bowel or rheumatological disease.ObjectivesTo evaluate whether an elevated ferritin level prior to pregnancy is associated with major adverse pregnancy outcomes.MethodsA population‐based cohort study was completed using Ontario, Canada. Included were all Ontarian women with a hospital livebirth or stillbirth at ≥20 weeks’ gestation, 2007‐2018, and serum haemoglobin and ferritin measured as an outpatient within 120 days before conception. Excluded were women with a diagnosed iron overload disorder or a ferritin concentration <15 µg/L. The main exposure was a pre‐pregnancy serum ferritin ≥95th percentile. Study outcomes included PTB < 37 weeks’ gestation, including clinician‐initiated and spontaneous PTB; PTB < 32 weeks; chorioamnionitis; and perinatal death. Relative risks (RR) and 95% confidence intervals (CI) were calculated for each study outcome, comparing a serum ferritin concentration ≥95th vs <5th percentile (the referent), while adjusting maternal age, residence, haemoglobin concentration, diabetes mellitus, inflammatory bowel disease, illicit drug/tobacco use, chronic kidney disease, chronic hypertension, sickle‐cell disease or thalassaemia, and rheumatological conditions.ResultsAmong 89 847 births, a preconceptional maternal serum ferritin ≥95th (112.0 μg/L) vs <5th (16.9 μg/L) percentile was associated with an adjusted relative risk (aRR) of 1.34 (95% CI 1.15, 1.57) for PTB, including spontaneous and clinician‐initiated PTB. Results were equivocal for chorioamnionitis (aRR 1.23, 95% CI 0.81, 1.86), and there was no association with perinatal mortality (aRR 0.94, 95% CI 0.55, 1.61).ConclusionA high preconceptional ferritin concentration is associated with some adverse perinatal outcomes.
Industry‐Dominated Science Advisory Boards Are Perceived To Be Legitimate…But Only When They Recommend More Stringent Risk Management Policies
Authors: Árvai Joseph , Gray Sara Goto , Raimi Kaitlin T. , Wilson Robyn , Drummond Caitlin 
Published: June 2020

AbstractIn 2017, the US Environmental Protection Agency (EPA) was criticized for two controversial directives that restricted the eligibility of academic scientists to serve on the agency's key science advisory boards (SABs). The EPA portrayed these directives as necessary to ensure the integrity of the SAB. Critics portrayed them as a tactic by the agency to advance a more industry‐friendly deregulatory agenda. With this backdrop, this research examined board composition and its effect on the perceived legitimacy of risk management recommendations by the SAB. In an experiment, we presented participants with hypothetical EPA SABs composed of different proportions of academic and industry scientists. We then asked participants to rate their satisfaction with, and the legitimacy of, these boards in light of their decisions in scenarios based on actual EPA SAB deliberations. Participants perceived higher levels of satisfaction and legitimacy when SABs made more stringent risk management recommendations. While SABs dominated by industry scientists were perceived to be more strongly motivated to protect business interests, we found no effect of board composition on perceptions of satisfaction and legitimacy. These results are consistent with prior research on decision quality that suggests people use normative outcomes as a heuristic for assessing the quality of deliberations. Moreover, these results suggest that members of the public are supportive of federal SABs regardless of their composition, but only if they take actions that are consistent with normative expectations.
Recognizing urban functional zones by a hierarchical fusion method considering landscape features and human activities
Authors: Liu Huimin , Xu Yiyuan , Tang Jianbo , Deng Min , Huang Jincai , Yang Wentao , Wu Fang 
Published: June 2020

AbstractFunctional zones are basic spatial units of urban management and urban planning and they provide the basic space where human activities occur. The concept of urban functional zones is closely related to two basic factors: urban landscape environment and human activities. The former provides the basic space for human activity and influences urban land use at a coarse scale, and the latter indicates the differentiation of functions in local urban areas. In previous studies, the hierarchical correspondence and interaction between urban landscape and human activities have not been given full consideration in the cognition of urban functional zones, which would influence the accuracy and interpretability of the results. Therefore, a hierarchical fusion method considering urban landscape and human activity patterns based on multi‐source data is proposed in this article. We introduce a new cognition framework. First, a land use classification based on urban landscape features from remote sensing images is extracted and used as the fundamental results of urban land uses. Then, fine‐grained functional semantics of local urban areas are recognized based on human activity patterns extracted from crowdsourced data (i.e., points of interest and taxi trajectories). Finally, the above results at different scales are fused with hierarchical constraints, which means that the information from both urban landscape and human activities can be fully utilized to obtain a refined and fine‐grained map of urban functional zones. Wuhan, China was chosen as an example to evaluate the performance of the proposed method. Results show that the overall accuracy of the proposed method is 82.51% (accuracies of the mixed functional zones and single functional zones are 77.93 and 87.96%, respectively) and compared with state‐of‐the‐art methods, the proposed method performed better for the recognition of mixed functional zones.
Development and validation of prediction rules to target care intensification in veteran patients with diabetes
Authors: Campbell Heather M , Murata Allison , Charlton Gerald A , Murata Glen H 
Published: June 2020

BackgroundDiabetes affects 30.3 million people in the USA. Among these people, a major risk factor for microvascular complications is having a glycated haemoglobin (HbA1c) value of ≥75 mmol/mol; therefore, it would be helpful to identify patients who will obtain future HbA1c values of <75 mmol/mol.ObjectivesTo develop and validate two prediction rules among patients with diabetes having a baseline HbA1c value of ≥75 mmol/mol: (1) HbA1c measurement ever <75 mmol/mol and (2) final HbA1c measurement of <75 mmol/mol.MethodsRetrospective cohort study using a registry extracting data from the Department of Veterans Affairs’s (VA’s) electronic health records system. Baseline was 1 Jul 2013–30 June 2014; patients were followed up until 31 July 2016.ResultsOur population consisted of 145 659 patients. Across models, predictors were age, sex, minority status, baseline HbA1c value, time, HbA1c≥75 mmol/mol, receiving insulin treatment and consecutive number of HbA1c values of 75 mmol/mol. The overall likelihood of a patient ever having an HbA1c<75 mmol/mol was 73.65%; with the rule, predicted probabilities were 38.94%, 50.75% and 78.88%. The overall likelihood of patients having a final HbA1c measurement of <75 mmol/mol was 55.35%; the rule provided predicted probabilities of 29.93%, 50.17% and 68.58%.ConclusionsWithin each rule, there were similar observed and predicted tertile probabilities; maintaining HbA1c values of <75 mmol/mol resulted in probability shifts in the majority of patients. We recommend psychosocial screening for 15% of patients for whom there is less than one-third chance of maintaining HbA1c<75 mmol/mol. We plan to conduct additional research to see whether this approach helps.
Randomised, non-inferiority, controlled procedural outcomes TrIal comParing reverse T And Protrusion versus double-kissing and crush stenting: protocol of the TIP TAP I randomised trial
Authors: Rakhimov Kudrat , Buono Andrea , Anadol Remzi , Ullrich Helen , Knorr Maike , Ahoopai Majid , Münzel Thomas , Gori Tommaso 
Published: June 2020

IntroductionTo assess the impact of ‘reverse T and Protrusion’ (TAP) technique on the outcome after stenting of true bifurcation lesions of the left main (LM) or proximal epicardial vessels as compared with double kissing (DK)-crush technique.Methods and analysis50 consecutive patients with true coronary bifurcation lesion (Medina 1,1,1 or 0,1,1) of the LM or the proximal main vessels, requiring a two-stent technique as first-line strategy at University Medical Center Mainz, are randomised in a 1:1 ratio to reverse TAP or DK-crush stenting. As recommended by best clinical practice, final angiographic result is evaluated and optical coherence tomographic (OCT) intracoronary imaging is performed to assess and optimise the final result. The primary end point is defined as the percentage of stent expansion in the side branch. Secondary end points consist of angiographic and procedural success (assessed until patient’s discharge), procedural parameters (procedural time, fluoroscopy time, use of devices, X-ray dose) and OCT parameters expressing expansion of the stents. Safety parameters include all adverse events up to 6 months after discharge. A clinical, angiographic and intracoronary imaging control at 6 months is planned.Ethics and disseminationThe protocol complies with good clinical practice and the ethical principles described in the Declaration of Helsinki and is approved by the local ethics committee. The results of the trial will be published as original article(s) in medical journals and/or as presentation at congresses.Trial registration numberClinicalTrials.gov Registry (NCT03714750)
‘Putting salt on the wound’: a qualitative study of the impact of FGM-safeguarding in healthcare settings on people with a British Somali heritage living in Bristol, UK
Authors: Karlsen Saffron , Carver Natasha , Mogilnicka Magda , Pantazis Christina 
Published: June 2020

ObjectivesThis research documents the experiences of people with Somali heritage with female genital mutilation (FGM)-safeguarding services in healthcare and whether such services are considered appropriate by the people who encounter them.DesignSix focus groups conducted with ethnic Somalis living in Bristol, during the summer of 2018, divided by gender and whether people had experienced FGM-safeguarding as adults or children.SettingParticipants experienced FGM-safeguarding in primary and secondary care.Participants30 people (21 women and 9 men), identified through local organisations or snowball sampling. All participants were of Somali heritage and aged over 18.ResultsGovernment priorities to support those who have experienced female genital cutting/mutilation (FGC/M) are being undermined by their own approaches to protect those considered at risk. Participants argued that approaches to FGM-safeguarding were based on outdated stereotypes and inaccurate evidence which encouraged health and other service providers to see every Somali parent as a potential perpetrator of FGC/M. Female participants described providers in a range of healthcare settings, including Accident and Emergency Departments (A&E), antenatal care and general practice, as ‘fixated’ with FGC/M, who ignored both their health needs and their experience as victims. Participants felt stigmatised and traumatised by their experience. This undermined their trust in health services, producing a reticence to seek care, treatment delays and reliance on alternative sources of care. Associated recommendations include developing more accurate evidence of risk, more appropriate education for healthcare providers and more collaborative approaches to FGM-safeguarding.ConclusionAll the participants involved in this study are committed to the eradication of FGC/M. But the statutory approaches currently adopted to enable this are considered ill-conceived, unnecessarily heavy-handed and ultimately detrimental to this. Recognising these common aims can enable the development of services better able to protect and support those at risk of FGC/M in ways which are culturally competent and sensitive.
Protocol for a systematic review and meta-analysis of long-term neurocognitive outcomes in paediatric traumatic brain injury
Authors: Looi Dawn Shu Hui , Goh Mark Sen Liang , Goh Sharon Si Min , Goh Jia Ling , Sultana Rehena , Lee Jan Hau , Chong Shu-Ling 
Published: June 2020

IntroductionChildren who suffer from traumatic brain injury (TBI) are at risk of permanent brain damage and developmental deficits. Reports on neurodevelopmental outcomes in paediatric TBI suffer from small sample size and varying outcome definitions in the neurocognitive domains tested. This protocol describes a systematic review and meta-analysis of paediatric TBI in the following key neurocognitive domains: executive function, perceptual–motor function, language, learning and memory, social cognition and complex attention.MethodsA comprehensive search comprising studies from Medline, Cochrane, Embase and PsycINFO published from 1988 to 2019 will be conducted. We will include studies on children ≤18 years old who suffer from mild, moderate and severe TBI as determined by the Glasgow Coma Scale that report neurocognitive outcomes in domains predetermined by the Diagnostic and Statistical Manual of Mental Disorders fifth edition criteria. Systematic reviews, meta-analyses, randomised controlled trials, case–control, cohort and cross-sectional studies will be included. References from systematic reviews and meta-analyses will be hand-searched for relevant articles. A meta-analysis will be performed and effect sizes will be calculated to summarise the magnitude of change in each neurocognitive domain compared at different timepoints and stratified by severity of TBI. Included studies will be pooled using pooled standardised mean differences with a random effects model to determine an overall effect. In the scenario that we are unable to pool the studies, we will perform a narrative analysis.Ethics and disseminationEthics approval is not required for this study.The authors of this study will publish and present the findings in a peer-reviewed journal as well as national and international conferences. The results of this study will provide understanding into the association between different severities of paediatric TBI and long-term neurocognitive outcomes.PROSPERO registration numberCRD42020152680.
Emergency contraception from the pharmacy 20 years on: a mystery shopper study
Authors: Glasier Anna , Baraitser Paula , McDaid Lisa , Norrie John , Radley Andrew , Stephenson Judith M , Battison Claire , Gilson Richard , Cameron Sharon ,   Trial Steering Committee
Published: June 2020

BackgroundEmergency contraception (EC) was approved in the UK as a pharmacy medicine for purchase without prescription in 2001. Twenty years later we conducted a study to characterise routine practice pharmacy provision of EC.Study designMystery shopper study of 30 pharmacies in Edinburgh, Dundee and London participating in a clinical trial of contraception after EC.MethodsMystery shoppers, aged ≥16 years, followed a standard scenario requesting EC. After the pharmacy visit, they completed a proforma recording the duration of the consultation, where it took place, and whether advice was given to them about the importance of ongoing contraception after EC.ResultsFifty-five mystery shopper visits were conducted. The median reported duration of the consultation with the pharmacist was 6 (range 1–18) min. Consultations took place in a private room in 34 cases (62%) and at the shop counter in the remainder. In 27 cases (49%) women received advice about ongoing contraception. Eleven women (20%) left the pharmacy without EC due to lack of supplies or of a trained pharmacist. Most women were generally positive about the consultation.ConclusionsWhile availability of EC from UK pharmacies has undoubtedly improved access, the necessity to have a consultation, however helpful, with a pharmacist introduces delays and around one in five of our mystery shoppers left without getting EC. Consultations in private are not always possible and little advice is given about ongoing contraception. It is time to make EC available without a pharmacy consultation.
International trends in oesophageal cancer survival by histological subtype between 1995 and 2014
Authors: Morgan Eileen , Soerjomataram Isabelle , Gavin Anna T , Rutherford Mark J , Gatenby Piers , Bardot Aude , Ferlay Jacques , Bucher Oliver , De Prithwish , Engholm Gerda , Jackson Christopher , Kozie Serena , Little Alana , Møller Bjorn , Shack Lorraine , Tervonen Hanna , Thursfield Vicky , Vernon Sally , Walsh Paul M , Woods Ryan R , Finley Christian , Merrett Neil , O’Connell Dianne L , Reynolds John V , Bray Freddie , Arnold Melina 
Published: June 2020

IntroductionSurvival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).MethodsThe ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995 to 2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to healthcare (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). 1-year and 3-year age-standardised net survival alongside incidence rates were calculated by country, subtype, sex, age group and period of diagnosis.Results111 894 cases of AC and 73 408 cases of SCC were included in the analysis. Marked improvements in survival were observed over the 20-year period in each country, particularly for AC, younger age groups and 1 year after diagnosis. Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. During 2010 to 2014, survival was higher for AC compared with SCC, with 1-year survival ranging from 46.9% (Canada) to 54.4% (Ireland) for AC and 39.6% (Denmark) to 53.1% (Australia) for SCC.ConclusionMarked improvements in both oesophageal AC and SCC survival suggest advances in treatment. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease.
What predicts poor outcome after successful thrombectomy in late time windows?
Authors: Heit Jeremy J , Mlynash Michael , Christensen Soren , Kemp Stephanie M , Lansberg Maarten G , Marks Michael P , Olivot Jean-Marc , Gregory Albers W 
Published: June 2020

BackgroundThrombectomy for acute ischemic stroke treatment leads to improved outcomes, but many patients do not achieve a good outcome despite successful reperfusion. We determined predictors of poor outcome after successful thrombectomy (TICI 2b–3) with an emphasis on modifiable factors.MethodsPatients from the randomized DEFUSE 3 trial who underwent thrombectomy with TICI 2b–3 revascularization were included. Primary outcome was a poor outcome at 90 days (modified Rankin Scale score 3–6).Results70 patients were included. Poor outcome patients were older (73.5 vs 66.5 years; P=0.01), more likely to be female (68% vs 39%; P=0.02), had higher NIHSS scores (20 vs 13; P<0.001), and had poor cerebral perfusion collaterals (hypoperfusion intensity ratio) (median 0.45 vs 0.38; P=0.03). Following thrombectomy, poor outcome patients had larger 24 hour’ core infarctions (median 59.5 vs 29.9 mL; P=0.01), more core infarction growth (median 33.6 vs 13.4 mL; P<0.001), and more mild (65% vs 50%; P=0.02) and severe (18% vs 0%; P=0.01) reperfusion hemorrhage. In a logistic regression analysis, the presence of any reperfusion hemorrhage (OR 3.3 [95% CI, 1.67 to 5]; P=0.001), age (OR 1.1 [95% CI, 1.03 to 1.11], P=0.004), higher NIHSS (OR 1.25 [95% CI, 1.07 to 1.41], P=0.002), and time from imaging to femoral artery puncture (OR 5 [95% CI, 1.16 to 16.67], P=0.03) independently predicted poor outcomes.ConclusionsIn late time windows, both mild and severe reperfusion hemorrhage were associated with poor outcomes. Older age, higher NIHSS, and increased time from imaging to arterial puncture were also associated with poor outcomes despite successful revascularization.Trial registrationhttps://clinicaltrials.gov/ct2/show/NCT02586415
On the size of rotating black holes
Authors: Feng Xing-Hui , Lü H. 
Published: June 2020

AbstractRecently a sequence of inequalities relating the black hole horizon, photon sphere, shadow were proposed for spherically symmetric and static black holes, providing the upper bound for given mass. In this paper, we extend the discussion to include rotating black holes. When viewed from the north pole direction, the shadow remains a round disk, but the image is skewed when viewed from the equatorial plane. After properly implementing the “size” parameters for the rotating black holes, we verify that the sequence of inequalities remain valid for a variety of solutions, including Kerr, Kerr–Newman, Kerr–Sen and Kerr–Cvetič–Youm black holes. The upshot is that rotation makes both the actual and apparent sizes of a black hole smaller.
Constraining power of open likelihoods, made prior-independent
Authors: Gariazzo S. 
Published: June 2020

AbstractOne of the most criticized features of Bayesian statistics is the fact that credible intervals, especially when open likelihoods are involved, may strongly depend on the prior shape and range. Many analyses involving open likelihoods are affected by the eternal dilemma of choosing between linear and logarithmic prior, and in particular in the latter case the situation is worsened by the dependence on the prior range under consideration. In this letter, we revive a simple method to obtain constraints that depend neither on the prior shape nor range and, using the tools of Bayesian model comparison, extend it to overcome the possible dependence of the bounds on the choice of free parameters in the numerical analysis. An application to the case of cosmological bounds on the sum of the neutrino masses is discussed as an example.