bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrochemical and operational parameters driving carbonate scale kinetics at geothermal facilities in the Bavarian Molasse Basin
Authors: Köhl Bernhard , Elsner Martin , Baumann Thomas 
Published: October 2020

AbstractThe majority of scales observed at geothermal facilities exploring the Malm Aquifer in the Bavarian Molasse Basin are carbonates. They form due to a disruption of the lime–carbonic acid equilibrium during production caused by a reduction of the partial pressure of carbon dioxide due to pressure change and degassing. These scales are found at the pumps, production pipes, filters, heat exchangers, and occasionally in the injection pipes. In this study, scales of all sections of geothermal facilities were taken. The database consists of scale samples from 13 geothermal pumps, 6,000 m production pipe (sample interval 10 - 12 m), 11 heat exchanger revisions, 2 injection pipes, and numerous filter elements. The samples were analyzed by SEM-EDX, XRD, Raman spectroscopy, and acid digestion to assess their chemical and mineralogical composition. From direct gauge measurements at six facilities during pump changes, scale rates were determined along the production pipes. From indirect measurements (multifinger caliper measurements) scale rates are derived for the region below the pump. Hydrochemical analyses from the wellhead were taken from 13 sites to feed the hydrogeochemical models. The calcite scale rates in the production pipes increase from the pump to the wellhead, where they reach 1.5 - 4.1 $$\mu$$μmol/($$\hbox {m}^2\,\cdot$$m2· s). Scale rates below the pump reach up to 1.5 $$\mu$$μmol/($$\hbox {m}^2\,\cdot$$m2· s). Given the slight change of hydrochemistry on the rise through the production pipe, where < 4 % of dissolved calcium ions precipitate as scale, scale rates cannot be derived from water samples at the wellhead, but require direct gauge measurements. The small amount of precipitation, together with fully turbulent conditions suggests that all measured rates are controlled by the surface-reaction of calcite crystallization following the nomenclature of Appelo and Postma (2004). Two approaches are used for the modeling of the scale rates. The first approach is based on hydrogeochemical modeling with PHREEQC. Scale rates calculated by this method are one order of magnitude higher than the measured ones. The second approach is based on correlations between the measured scale rates at the wellhead at six facilities and identified thermodynamic scale drivers ($$\Delta$$Δ log (p$$\hbox {CO}_2$$CO2),$$\Delta$$Δtotal pressure,$$\Delta$$Δ pH, and$$\hbox {SI}_{{calcite}}$$SIcalcite). The correlations allow linear regressions which are used for the prediction of the scale rate at the wellhead, along the whole production pipe, and below. The modeling results show that scale prediction based on the new regressions that rely on thermodynamic scale drivers works better than existing hydrogeochemical models, already without implementation of kinetic parameters ($$\hbox {CO}_2$$CO2-stripping and magnesium inhibition).
Application of the technical - pedagogical resource 3D holographic LED-fan display in the classroom
Authors: Prado Ortega Mauricio Xavier , Delgado Ramírez Jorge Cristopher , Valarezo Castro Jorge Washington , Armijos Carrión Jorge Luis , Ávila Carvajal Asisclo Alfonso , González Segarra Anyeline Natalia 
Published: October 2020

AbstractThe currently secondary education needs the contribution of new techno-pedagogical resources, where the resource, teaching and learning skills are integrated to motivate students in their learning. For this reason, the field of holographics is presented as a dynamic alternative to the growing use of image projectors. However, these resources are not available to teachers and educational institutions because of their high costs. This research seeks to show how led-based technologies can be applied in secondary education, so allow the classroom attention of students and improve their interest in learning through the use of the 3D Holographic LED-Fan Display. In this way, the objective is to improve the student’s motivation for learning using current resources according to the realities of the current context of education, which may not have availability of mobile devices due to their high costs, thus they have not been considered for the present study. The research approach is a mixed methodology combining qualitative and quantitative information through an educational study case applied to the Kléber Franco Cruz School with the intervention of pre-professional practices carried out by the Technical University of Machala in Ecuador, through the realization of an integrative knowledge project with students with different profiles according to their curriculum, in order to face the different challenges of teaching.
One health approach to tackle brucellosis: a systematic review
Authors: Ghanbari Mahboubeh Khaton , Gorji Hasan Abolghasem , Behzadifar Masoud , Sanee Nadia , Mehedi Nafiul , Bragazzi Nicola Luigi 
Published: October 2020

Abstract
Background
Brucellosis is the most significant and common bacterial zoonosis and is recognized as a re-emerging and neglected disease. Tackling zoonosis is very important for the health and the economy. One Health is an approach characterized by the integration of human and animal health, plants, and ecosystems and encourages joining local, national, and global multidisciplinary efforts to achieve optimal levels of health and collaboration among different disciplines to address complex health problems.

Objectives
The present study aimed to review published scientific literature related to the use of the One Health approach to tackle human brucellosis.

Methods
Web of Science (WoS), PubMed, Scopus, The Cochrane Library, and Embase databases were searched from inception until 30 January 2020. The reference lists of all relevant papers were hand-searched. Two authors extracted data from published studies independently. The Joanna Briggs Institute tool was used to assess the quality of studies.

Results
Of 2297 studies, 10 studies were deemed eligible, which were conducted between 2013 and 2019. Studies were performed in Uganda, Malta, Serbia, Greece, Mongolia, Azerbaijan, Israel, India, Ethiopia, and the USA. All studies suggested that brucellosis is still a major public health problem and that the most important aspect of the One Health approach is the interdependence of humans, ecosystems, and animals .Some studies have focused on livestock vaccination as the most effective way to prevent disease, and others have focused on the biology of Brucella infection and its transmission patterns. Some studies have pointed to the effectiveness of the One Health approach in all the phases of disease management as well as to its role in reducing health costs.

Conclusion
The success of the approach depends on the willingness of the decision-makers to implement the necessary policies. Due to the heterogeneity of current practices, and organizations involved in One Health approach-based programs, it will be incomplete without proper planning. To better implement the approach, strategies should be appraised and disseminated by experts and relevant stakeholders.
3D printed bone models in oral and cranio-maxillofacial surgery: a systematic review
Authors: Meglioli Matteo , Naveau Adrien , Macaluso Guido Maria , Catros Sylvain 
Published: October 2020

Abstract
Aim
This systematic review aimed to evaluate the use of three-dimensional (3D) printed bone models for training, simulating and/or planning interventions in oral and cranio-maxillofacial surgery.

Materials and methods
A systematic search was conducted using PubMed® and SCOPUS® databases, up to March 10, 2019, by following the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) protocol. Study selection, quality assessment (modified Critical Appraisal Skills Program tool) and data extraction were performed by two independent reviewers. All original full papers written in English/French/Italian and dealing with the fabrication of 3D printed models of head bone structures, designed from 3D radiological data were included.
Multiple parameters and data were investigated, such as author’s purpose, data acquisition systems, printing technologies and materials, accuracy, haptic feedback, variations in treatment time, differences in clinical outcomes, costs, production time and cost-effectiveness.

Results
Among the 1157 retrieved abstracts, only 69 met the inclusion criteria. 3D printed bone models were mainly used as training or simulation models for tumor removal, or bone reconstruction. Material jetting printers showed best performance but the highest cost. Stereolithographic, laser sintering and binder jetting printers allowed to create accurate models with adequate haptic feedback. The cheap fused deposition modeling printers exhibited satisfactory results for creating training models.

Conclusion
Patient-specific 3D printed models are known to be useful surgical and educational tools. Faced with the large diversity of software, printing technologies and materials, the clinical team should invest in a 3D printer specifically adapted to the final application.
Noise2Atom: unsupervised denoising for scanning transmission electron microscopy images
Authors: Wang Feng , Henninen Trond R. , Keller Debora , Erni Rolf 
Published: October 2020

AbstractWe propose an effective deep learning model to denoise scanning transmission electron microscopy (STEM) image series, named Noise2Atom, to map images from a source domain $\mathcal {S}$
S
to a target domain $\mathcal {C}$
C
, where $\mathcal {S}$
S
is for our noisy experimental dataset, and $\mathcal {C}$
C
is for the desired clear atomic images. Noise2Atom uses two external networks to apply additional constraints from the domain knowledge. This model requires no signal prior, no noise model estimation, and no paired training images. The only assumption is that the inputs are acquired with identical experimental configurations. To evaluate the restoration performance of our model, as it is impossible to obtain ground truth for our experimental dataset, we propose consecutive structural similarity (CSS) for image quality assessment, based on the fact that the structures remain much the same as the previous frame(s) within small scan intervals. We demonstrate the superiority of our model by providing evaluation in terms of CSS and visual quality on different experimental datasets.
Updated Breast Cancer Surveillance Recommendations for Female Survivors of Childhood, Adolescent, and Young Adult Cancer From the International Guideline Harmonization Group
Authors: Mulder Renée L. , Hudson Melissa M. , Bhatia Smita , Landier Wendy , Levitt Gill , Constine Louis S. , Wallace W. Hamish , van Leeuwen Flora E. , Ronckers Cécile M. , Henderson Tara O. , Moskowitz Chaya S. , Friedman Danielle N. , Ng Andrea K. , Jenkinson Helen C. , Demoor-Goldschmidt Charlotte , Skinner Roderick , Kremer Leontien C.M. , Oeffinger Kevin C. 
Published: October 2020

PURPOSE As new evidence is available, the International Late Effects of Childhood Cancer Guideline Harmonization Group has updated breast cancer surveillance recommendations for female survivors of childhood, adolescent, and young adult cancer. METHODS We used evidence-based methods to apply new knowledge in refining the international harmonized recommendations developed in 2013. The guideline panel updated the systematic literature review, developed evidence summaries, appraised the evidence, and updated recommendations on the basis of evidence, clinical judgement, and consideration of benefits versus the harms of the surveillance interventions while attaining flexibility in implementation across different health care systems. The GRADE Evidence-to-Decision framework was used to translate evidence to recommendations. A survivor information form was developed to counsel survivors about the potential harms and benefits of surveillance. RESULTS The literature update identified new study findings related to the effects of prescribed moderate-dose chest radiation (10 to 19 Gy), radiation dose-volume, anthracyclines and alkylating agents in non–chest irradiated survivors, and the effects of ovarian function on breast cancer risk. Moreover, new data from prospective investigations were available regarding the performance metrics of mammography and magnetic resonance imaging among survivors of Hodgkin lymphoma. Modified recommendations include the performance of mammography and breast magnetic resonance imaging for survivors treated with 10 Gy or greater chest radiation (strong recommendation) and upper abdominal radiation exposing breast tissue at a young age (moderate recommendation) at least annually up to age 60 years. As a result of inconsistent evidence, no recommendation could be formulated for routine breast cancer surveillance for survivors treated with any type of anthracyclines in the absence of chest radiation. CONCLUSION The newly identified evidence prompted significant change to the recommendations formulated in 2013 related to moderate-dose chest radiation and anthracycline exposure as well as breast cancer surveillance modality.
Biochemical Remission after Cabergoline Withdrawal in Hyperprolactinemic Patients with Visible Remnant Pituitary Adenoma
Authors: Kim Kyungwon , Park Yae Won , Kim Daham , Ahn Sung Soo , Moon Ju Hyung , Kim Eui Hyun , Lee Eun Jig , Ku Cheol Ryong 
Published: October 2020

Abstract

Context
Dopamine agonists (DAs) are the first-line therapy for prolactinomas. Although pituitary tumors often do not completely disappear, discontinuing DAs in patients with no visible tumor on magnetic resonance imaging is advised.

Objective
To analyze biochemical remission after cabergoline (CAB) withdrawal in patients with visible remnant pituitary tumors.

Design
Retrospective cohort study.

Setting
Severance Hospital.

Subjects
We identified 734 patients with prolactinomas undergoing CAB therapy for at least 12 months from 2005 to 2018. We selected 44 patients with prolactinomas who discontinued CAB with normal prolactin levels; they were receiving a minimal CAB dose but had visible remnant tumors.

Results
Median age at diagnosis was 32 (18-58) years, and most patients were women (95.45%). Median treatment duration was 32 (12-120) months. Of 44 patients, 33 continued to have normoprolactinemia, but 11 patients developed hyperprolactinemia after drug withdrawal within 26 (12-97) months. Age, sex, maximal and remnant tumor size, and treatment duration were similar between the groups. The initial prolactin level and chances of cavernous sinus (CS) invasion were higher in the recurrence group. CS invasion at diagnosis was associated with an increased recurrence rate. Although treatment response did not correlate with the initial and final signal intensity assessments, a significant decrease in T2 intensity ratio after 6 months of CAB therapy was observed in the remission group (P = .043).

Conclusion
In patients with visible tumors, the presence of CS invasion at diagnosis may be an unfavorable predictor for biochemical remission after CAB discontinuation.
Excitonic Energy Level of Homo- and Hetero-Dimers and Their Composition in the Native Water-Soluble Chlorophyll Protein from Lepidium Virginicum
Authors: Ohtsuki Takayuki , Uchida Akira , Nishigaki Atsuko , Nagashima Umpei , Takahashi Shigekazu , Ohshima Shigeru 
Published: October 2020

Abstract
The native water-soluble chlorophyll protein, CP663, extracted from Lepidium virginicum, consists of four subunits, each with one chlorophyll (Chl), and the four Chls form two dimers in an orthogonal arrangement. Accordingly, CP663 is considered to have three dimers, Chl a–Chl a (AA), Chl a–Chl b (AB), and Chl b–Chl b (BB), in a certain composition and to provide six excitonic transitions because each dimer gives rise to low (L)- and high (H)-energy transitions. To investigate the excitonic transitions and the dimeric composition, the absorption and circular dichroism spectra of CP663 were measured and the electronic transitions of the dimers were calculated by Zerner’s intermediate neglect of differential overlap method. On the basis of the experimental and calculated results, the Qy-absorption band was deconvoluted by the Gaussian fitting method. The resulting six Gaussian components were assigned to the individual transitions and the excitonic transition energy was found to increase in the order AAL, ABL, AAH, BBL, ABH, and BBH. From the spectral areas of the components, the composition of the dimers was calculated as AA:AB:BB = 0.52:0.34:0.14, indicating that CP663 accommodates the homodimers in preference to the heterodimer.
Functionalization of Self-supporting Graphene with a High Grafting Yield for Hydrophilicity Improvement
Authors: Xin Guoxiang , Wang Mengmeng , Zhai Yao , Zhang Bangwen , Song Jinling , Liu Xiaoxu 
Published: October 2020

Abstract
The functionalization of self-supporting graphene (SSG) which in-situ grows on a flexible graphite sheet is performed by an electrochemical exfoliation in a HCl solution and then a diazonium reaction using p-aminobenzenesulfonic acid. The functionalized SSG is defined as F-SSG. The grafting yield of benzenesulfonic acid groups on F-SSG is up to 7.5%. The conductivity of the F-SSG is 502.7 S/cm. The water contact angle of F-SSG is only 28.6°, which is much smaller than that of SSG, displaying good hydrophilicity.
Protocol for a proof-of-concept observational study evaluating the potential utility and acceptability of a telemedicine solution for the post-anesthesia care unit
Authors: Budelier Thaddeus P. , King Christopher Ryan , Goswami Shreya , Bansal Anchal , Gregory Stephen H. , Wildes Troy S. , Abraham Joanna , McKinnon Sherry L. , Cooper Amy , Kangrga Ivan , Martin, Jr. Jackie L. , Milbrandt Melissa , Evers Alex S. , Avidan Michael S. 
Published: October 2020

Introduction: The post-anesthesia care unit (PACU) is a clinical area designated for patients recovering from invasive procedures. There are typically several geographically dispersed PACUs within hospitals. Patients in the PACU can be unstable and at risk for complications. However, clinician coverage and patient monitoring in PACUs is not well regulated and might be sub-optimal. We hypothesize that a telemedicine center for the PACU can improve key PACU functions. Objectives: The objective of this study is to demonstrate the potential utility and acceptability of a telemedicine center to complement the key functions of the PACU. These include participation in hand-off activities to and from the PACU, detection of physiological derangements, identification of symptoms requiring treatment, recognition of situations requiring emergency medical intervention, and determination of patient readiness for PACU discharge. Methods and analysis: This will be a single center prospective before-and-after proof-of-concept study. Adults (18 years and older) undergoing elective surgery and recovering in two selected PACU bays will be enrolled. During the initial three-month observation phase, clinicians in the telemedicine center will not communicate with clinicians in the PACU, unless there is a specific patient safety concern. During the subsequent three-month interaction phase, clinicians in the telemedicine center will provide structured decision support to PACU clinicians. The primary outcome will be time to PACU discharge readiness determination in the two study phases. The attitudes of key stakeholders towards the telemedicine center will be assessed. Other outcomes will include detection of physiological derangements, complications, adverse symptoms requiring treatments, and emergencies requiring medical intervention. Registration: This trial is registered on clinicaltrials.gov, NCT04020887 (16th July 2019).
Comprehensive yield model for plantation teak in Panama
Authors: Seppänen Petteri , Mäkinen Antti 
Published: October 2020

The purpose of this study was to prepare a comprehensive, computerized teak ( L.f) plantation yield model system that can be used to describe the forest dynamics, predict growth and yield and support forest planning and decision-making. Extensive individual tree and permanent sample plot data were used to develop tree-level volume models, taper curve models and stand-level yield models for teak plantations in Panama. Tree volume models were satisfactorily validated against independent measurement data and other published models. Tree height as input parameter improved the stem volume model marginally. Stand level yield models produced comparable harvest volumes with models published in the literature. Stand level volume product outputs were found like actual harvests with an exception that the models marginally underestimate the share of logs in very large diameter classes. The kind of comprehensive model developed in this study and implemented in an easy to use software package provides a very powerful decision support tool. Optimal forest management regimes can be found by simulating different planting densities, thinning regimes and final harvest ages. Forest practitioners can apply growth and yield models in the appropriate stand level inventory data and perform long term harvest scheduling at property level or even at an entire timberland portfolio level. Harvest schedules can be optimized using the applicable financial parameters (silviculture costs, harvesting costs, wood prices and discount rates) and constraints (market size and operational capacity).Tectona grandis
Are Patients With Inflammatory Bowel Disease at an Increased Risk of Developing SARS-CoV-2 than Patients Without Inflammatory Bowel Disease? Results From a Nationwide Veterans' Affairs Cohort Study
Authors: Khan Nabeel , Patel Dhruvan , Xie Dawei , Pernes Tyler , Lewis James , Yang Yu-Xiao 
Published: October 2020

INTRODUCTION:
The clinic course of SARS-CoV-2 among patients with inflammatory bowel disease (IBD) has been extensively studied. However, there is a paucity of data on whether patients with IBD have an increased risk of developing SARS-CoV-2 with compared with patients without IBD.

METHODS:
We conducted a nationwide retrospective cohort study in the US Veterans’ Affairs healthcare system from January 1, 2020, to June 30, 2020. We matched each patient with IBD with 2 patients without IBD on age, sex, race, location, and comorbidities. The outcome of interest was development of SARS-CoV-2.

RESULTS:
Among 38,378 patients with IBD and 67,433 patients without IBD, 87 (0.23%) and 132 (0.20%) patients developed incident SARS-CoV-2 infection, respectively (P = 0.29).

DISCUSSION:
Patients with IBD are not at a significantly increased risk of developing SARS-CoV-2 infection when compared with patients without IBD.
Positive Effect of Bimodal Release Ondansetron in Irritable Bowel Syndrome With Diarrhea: Relevance of Low-Grade Inflammation?
Authors: Melchior Chloé , Simrén Magnus 
Published: October 2020

Abstract
There is a clear unmet need for new treatments in irritable bowel syndrome with diarrhea (IBS-D). Ondansetron, an old 5-hydroxy-tryptamine3 antagonist, used for chemotherapy-induced nausea and vomiting and with favorable side effect profile, has shown promising results in previous trials. In this issue, efficacy with a novel bimodal release ondansetron formulation was presented in IBS-D. The bimodal release ondansetron improved stool consistency, presumably by slowing transit time, and tended to improve other IBS symptoms as well. The authors proposed C-reactive protein levels as a tool to select responders because a better response was seen in patients with slightly elevated C-reactive protein levels. Future large-scale studies will determine the role of bimodal release ondansetron in IBS-D with and without low-grade inflammation.