bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a fidelity measure of early intervention programs for children with neuromotor disorders
Authors: An Mihee , Nord Jayden , Koziol Natalie A , Dusing Stacey C , Kane Audrey E , Lobo Michele A , Mccoy Sarah W , Harbourne Regina T 
Published: October 2020

AimTo describe the development of an intervention‐specific fidelity measure and its utilization and to determine whether the newly developed Sitting Together and Reaching to Play (START‐Play) intervention was implemented as intended. Also, to quantify differences between START‐Play and usual early intervention (uEI) services.MethodA fidelity measure for the START‐Play intervention was developed for children with neuromotor disorders by: (1) identifying key intervention components, (2) establishing a measurement coding system, and (3) testing the reliability of instrument scores. After establishing acceptable interrater reliability, 103 intervention videos from the START‐Play randomized controlled trial were coded and compared between the START‐Play and uEI groups to measure five dimensions of START‐Play fidelity, including adherence, dosage, quality of intervention, participant responsiveness, and program differentiation.ResultsFifteen fidelity variables out of 17 had good to excellent interrater reliability evidence with intraclass correlation coefficients (ICCs) ranging from 0.77 to 0.95. The START‐Play therapists met the criteria for acceptable fidelity of the intervention (rates of START‐Play key component use ≥0.8; quality ratings ≥3 [on a scale of 1–4]). The START‐Play and uEI groups differed significantly in rates of START‐Play key component use and quality ratings.InterpretationThe START‐Play fidelity measure successfully quantified key components of the START‐Play intervention, serving to differentiate START‐Play from uEI.
Inhaled corticosteroids and risk of lung cancer: A systematic review and meta‐analysis
Authors: Lin Ping , Fu Siyu , Li Weijing , Hu Yuehong , Liang Zongan 
Published: October 2020

AbstractIntroductionCurrent studies investigating the association between inhaled corticosteroid (ICS) use and risk of lung cancer have yielded inconsistent findings. The aim of this systematic review and meta‐analysis was to pool all currently available data to estimate this association.MethodsWe systematically searched MEDLINE (1946 to July 2020), EMBASE (1974 to July 2020) and the Cochrane Library (June 2020) via Ovid to identify relevant articles investigating the association between the ICS use and the risk of lung cancer. Random‐effects analysis was used to calculate pooled relative risks (RRs) with 95% confidence intervals (CIs).ResultsTen articles including 234 920 patients were analysed. ICS use was identified to have a decreased risk of lung cancer in chronic obstructive pulmonary disease (8 studies, 1806 patients; RR = 0.73, 95% CI: 0.61–0.87, P < .01; I2 = 60.0 %), asthma (1 study, 41 438 patients; RR = 0.44, 95% CI: 0.34–0.57, P < .01) and mixed (1 study, 46 225 patients; RR = 0.79, 95% CI: 0.69–0.90, P < .01) patients. The findings of reduced risk of lung cancer were consistent in all subgroup analyses except for the short‐term follow‐up (≤5 years) (RR = 0.94, 95% CI: 0.81‐1.07, P = .34) and free of immortal time bias (RR = 0.94, 95% CI: 0.82‐1.08, P = .38) subgroups.ConclusionsThe present study suggested that ICS use was associated with decreased risk of lung cancer. However, our findings should be interpreted with caution because most original studies were judged to be at high risk of immortal time bias.
The role of ROTEM variables based on clot elasticity and platelet component in predicting bleeding risk in thrombocytopenic critically ill neonates
Authors: Parastatidou Stavroula , Sokou Rozeta , Tsantes Andreas G , Konstantinidi Aikaterini , Lampridou Maria , Ioakeimidis Georgios , Panagiotounakou Polytimi , Kyriakou Elias , Kokoris Styliani , Gialeraki Argyri , Douramani Panagiota , Iacovidou Nicoletta , Piovani Daniele , Bonovas Stefanos , Nikolopoulos Georgios , Tsantes Argirios E 
Published: October 2020

AbstractBackgroundOur aim was to investigate the role of thromboelastometry (ROTEM) parameters, including maximum clot elasticity (MCE) and platelet component (PLTEM MCE and PLTEM MCF), in early prediction of bleeding events in thrombocytopenic critically ill neonates.Material and methodsThis single‐center, prospective cohort study included 110 consecutive thrombocytopenic neonates with sepsis, suspected sepsis, or hypoxia. On the first day of disease onset, ROTEM EXTEM and FIBTEM assays were performed and the neonatal bleeding assessment tool was used for the evaluation of bleeding events.ResultsMost EXTEM and FIBTEM ROTEM parameters significantly differed between neonates with (n = 77) and without bleeding events (n = 33). Neonates with bleeding events had significantly lower PLTEM MCE and PLTEM MCF values compared to those without bleeding events (P < .001). Platelet count was found to be strongly positively correlated with EXTEM A5 (Spearman's rho = 0.61, P < .001) and A10 (rho = 0.64, P < .001). EXTEM A10 demonstrated the best prognostic performance (AUC = 0.853) with an optimal cutoff value (≤37 mm) (sensitivity = 91%, specificity = 76%) for prediction of bleeding events in thrombocytopenic neonates.ConclusionsEXTEM A5 and EXTEM A10 were found to be strong predictors of hemorrhage, compared to most ROTEM variables quantifying clot elasticity and platelet component in thrombocytopenic critically ill neonates.
Normative range parenting and the developing brain: A scoping review and recommendations for future research
Authors: Farber Madeline J. , Gee Dylan G. , Hariri Ahmad R. 
Published: October 2020

AbstractStudies of early adversity such as trauma, abuse, and neglect highlight the critical importance of quality caregiving in brain development and mental health. However, the impact of normative range variability in caregiving on such biobehavioral processes remains poorly understood. Thus, we lack an essential foundation for understanding broader, population‐representative developmental mechanisms of risk and resilience. Here, we conduct a scoping review of the extant literature centered on the question, “Is variability in normative range parenting associated with variability in brain structure and function?” After removing duplicates and screening by title, abstract, and full‐text, 23 records were included in a qualitative review. The most striking outcome of this review was not only how few studies have explored associations between brain development and normative range parenting, but also how little methodological consistency exists across published studies. In light of these limitations, we propose recommendations for future research on normative range parenting and brain development. In doing so, we hope to facilitate evidence‐based research that will help inform policies and practices that yield optimal developmental trajectories and mental health as well as extend the literature on the neurodevelopmental impact of early life stress.
Integrating genetic and clinical data to predict impulse control disorders in Parkinson's disease
Authors: Jesús S. , Periñán M. T. , Cortés C. , Buiza‐Rueda D. , Macías‐García D. , Adarmes A. , Muñoz‐Delgado L. , Labrador‐Espinosa M. Á. , Tejera‐Parrado C. , Gómez‐Garre M. P. , Mir P. 
Published: October 2020

Background and purposeImpulse control disorders (ICDs) are frequent in Parkinson’s disease (PD), with associated clinical and genetic risk factors. This study was aimed at analyzing the clinical features and the genetic background that underlie ICDs in PD.MethodsWe included 353 patients with PD in this study (58.9% men, mean age 62.4 ± 10.58 years, mean age at disease onset 52.71 ± 11.94 years). We used the validated Questionnaire for Impulsive–Compulsive Disorders in Parkinson’s Disease for ICDs screening. Motor, nonmotor, and treatment‐related features were evaluated according to the presence of ICDs. Twenty‐one variants related to dopaminergic, serotonergic, glutamatergic, and opioid neurotransmitter systems were assessed. Association studies between polymorphisms and ICDs were performed. The combination of clinical and genetic variables was analyzed with receiver operating characteristic curves to assess the predictability of experiencing ICDs.ResultsImpulse control disorders appeared in 25.1% of the cases. Patients with ICDs were younger and presented a higher rate of anxiety. Treatment with dopamine agonists increased the risk of ICDs and it was dose dependent (P < 0.05). Genetic association studies showed that the DOPA decarboxylase gene (DDC), rs1451375, might modulate the risk of ICDs. Plotting the clinical–genetic model, the predictability of ICDs increased 11% (area under curve = 0.80; z = 3.22, P = 0.001) when adding the genotype data for single nucleotide polymorphisms.ConclusionsPolymorphisms in DDC might act as risk markers for ICDs in PD. The predictability of experiencing ICDs increased by adding genetic factors to clinical features. It is therefore important to assess the patient’s genetic background to identify individuals at risk for ICDs.
Clinical correlations and long‐term follow‐up in 100 patients with sarcoglycanopathies
Authors: Guimarães‐Costa R. , Fernández‐Eulate G. , Wahbi K. , Leturcq F. , Malfatti E. , Behin A. , Leonard‐Louis S. , Desguerre I. , Barnerias C. , Nougues M. C. , Isapof A. , Estournet‐Mathiaud B. , Quijano‐Roy S. , Fayssoil A. , Orlikowski D. , Fauroux B. , Richard I. , Semplicini C. , Romero N. B. , Querin G. , Eymard B. , Laforêt P. , Stojkovic T. 
Published: October 2020

Background and purposeTo describe a large series of patients with α, β, and γ sarcoglycanopathies (LGMD‐R3, R4, and R5) and study phenotypic correlations and disease progression.MethodsA multicentric retrospective study in four centers in the Paris area collecting neuromuscular, respiratory, cardiac, histologic, and genetic data. The primary outcome of progression was age of loss of ambulation (LoA); disease severity was established according to LoA before or after 18 years of age. Time‐to‐event analysis was performed.ResultsOne hundred patients (54 γ‐SG; 41 α‐SG; 5 β‐SG) from 80 families were included. The γ‐SG patients had earlier disease onset than α‐SG patients (5.5 vs. 8 years; p = 0.022) and β‐SG patients (24.4 years). Axial muscle weakness and joint contractures were frequent and exercise intolerance was observed. At mean follow‐up of 22.9 years, 65.3% of patients were wheelchair‐bound (66.7% α‐SG, 67.3% γ‐SG, 40% β‐SG). Dilated cardiomyopathy occurred in all sarcoglycanopathy subtypes, especially in γ‐SG patients (p = 0.01). Thirty patients were ventilated and six died. Absent sarcoglycan protein expression on muscle biopsy and younger age at onset were associated with earlier time to LoA (p = 0.021 and p = 0.002). Age at onset was an independent predictor of both severity and time to LoA (p = 0.0004 and p = 0.009). The α‐SG patients showed genetic heterogeneity, whereas >90% of γ‐SG patients carried the homozygous c.525delT frameshift variant. Five new mutations were identified.ConclusionsThis large multicentric series delineates the clinical spectrum of patients with sarcoglycanopathies. Age at disease onset is an independent predictor of severity of disease and LoA, and should be taken into account in future clinical trials.
Temporal pole epilepsy surgery—Sparing the hippocampus
Authors: Herlin Bastien , Adam Claude , Habert Marie Odile , Mathon Bertrand , Clemenceau Stéphane , Navarro Vincent , Dupont Sophie 
Published: October 2020

AbstractTemporal pole epilepsy (TPE) is a poorly known and difficult to individualize subtype of temporal lobe epilepsy. Consequently, in drug‐resistant TPE, there is still a debate on the need for a large surgical removal of the temporal pole and mesial temporal structures or a limited resection of the temporal pole. We reviewed all patients who underwent presurgical evaluation for drug‐resistant epilepsy over a 17‐year period, and report here 19 patients with proven drug‐resistant temporal pole epilepsy who underwent a selective temporal pole resection with respect to mesial structures. Most (15) TPE patients exhibited seizures resembling mesiotemporal seizures, whereas the others exhibited nocturnal hyperkinetic seizures or an association of both seizure types. MRI revealed a temporal pole lesion in 58% of patients. Long‐term postoperative outcome after a conservative surgery was excellent: 63% of patients were seizure‐free (International League Against Epilepsy [ILAE] 1) at 1‐year postsurgery and 78% at 5 years. These results show that TPE has no specific electroclinical features but is a distinct type of temporal lobe epilepsy allowing a conservative surgery. Respecting the mesiotemporal structures is a valid surgical approach for drug‐resistant temporal pole epilepsy.
Topological alterations in older adults with temporal lobe epilepsy are distinct from amnestic mild cognitive impairment
Authors: Kaestner Erik , Reyes Anny , Wang Zhong Irene , Drane Daniel L. , Punia Vineet , Hermann Bruce , Busch Robyn M. , McDonald Carrie R. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: October 2020

AbstractEpilepsy incidence and prevalence peaks in older adults, yet systematic studies of brain aging and epilepsy remain limited. We investigated topological network disruption in older adults with temporal lobe epilepsy (TLE; age > 55 years). Additionally, we examined the potential network disruption overlap between TLE and amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer disease. Measures of network integration (“global path efficiency”) and segregation (“transitivity” and “modularity”) were calculated from cortical thickness covariance from 73 TLE subjects, 79 aMCI subjects, and 70 healthy controls. Compared to controls, TLE patients demonstrated abnormal measures of segregation (increased transitivity and decreased modularity) and integration (decreased global path efficiency). aMCI patients also displayed increased transitivity and decreased global path efficiency, but these differences were less pronounced than in TLE. At the local level, TLE patients demonstrated decreased local path efficiency focused in the bilateral temporal lobes, whereas aMCI patients had a more frontal‐parietal distribution. These results suggest that network disruption at the global and local level is present in both disorders, but global disruption may be a particularly salient feature in older adults with TLE. These findings motivate further research into whether these network changes have distinct cognitive correlates or are progressive in older adults with epilepsy.
Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center
Authors: Cerulli Irelli Emanuele , Morano Alessandra , Barone Francesca A. , Fisco Giacomo , Fanella Martina , Orlando Biagio , Fattouch Jinane , Manfredi Mario , Giallonardo Anna Teresa , Di Bonaventura Carlo 
Published: October 2020

AbstractObjectiveTo assess prognostic patterns and investigate clinical and electroencephalography (EEG) variables associated with persistent treatment resistance in a population of genetic generalized epilepsy (GGE) patients with a long‐term follow‐up.MethodsData from GGE patients followed from 1975 to 2019 were reviewed retrospectively. Subjects with a follow‐up >10 years, starting from epilepsy diagnosis, were included. Persistent treatment resistance was defined as the absence of any period of remission ≥1 year despite treatment with two appropriate and adequate antiepileptic drugs (AEDs).ResultsOne hundred ninety‐nine patients were included. The median age was 39.5 years (interquartile range [IQR] 30‐49) and the median follow‐up was 27 years (IQR 18‐35). The most common syndrome was juvenile myoclonic epilepsy (JME), diagnosed in 44.2% of patients. During follow‐up, 163 subjects (81.9%) experienced 3‐year remission from any seizure type, whereas 5‐ and 10‐year remission occurred in 141 (70.8%) and 92 (46.2%) cases, respectively. The most common prognostic pattern was a relapsing‐remitting course, observed in 80 patients (40.2%), whereas 29 (14.6%) displayed persistent treatment resistance. According to multivariable logistic regression analysis, febrile seizures (FS), specific EEG patterns (namely generalized paroxysmal fast activity, GPFA) and valproate (VPA) resistance were the only variables significantly associated with persistent treatment resistance. JME was the only epilepsy syndrome statistically associated with persistent treatment resistance in univariable logistic regression analysis.SignificancePersistent treatment resistance was observed in almost 15% of GGE patients followed in a tertiary epilepsy center. A worse outcome was associated with specific clinical variables (JME, FS) and EEG patterns (GPFA).
Surveillance for Spodoptera frugiperda, fall armyworm (Lepidoptera: Noctuidae) in South Korea
Authors: Suh Soo‐Jung 
Published: October 2020

AbstractThe Animal and Plant Quarantine Service, South Korea, developed a specific plan for Spodoptera frugiperda (J.E. Smith), the fall armyworm, in 2019 to implement the surveillance for early detection for this pest. The fall armyworm surveillance program involved seasonal monitoring of the pest with pheromone traps placed into fields of cereal crops at high‐risk locations. In 2019, the trapping season ran from early spring to late autumn, with a total deployment of 140 traps. During the season, a total of 10 male adults were captured in these surveillance traps placed in South Korea and it has since been eradicated from these localities. Additionally, the fall armyworm was intercepted 12 times on asparagus from Peru and Thailand at South Korean ports of entry.
Antibiotics with therapeutic effects on spinal cord injury: a review
Authors: Afshari Khashayar , Momeni Roudsari Nazanin , Lashgari Naser‐Aldin , Haddadi Nazgol‐Sadat , Haj‐Mirzaian Arvin , Hassan Nejad Malihe , Shafaroodi Hamed , Ghasemi Mehdi , Dehpour Ahmad Reza , Abdolghaffari Amir Hossein 
Published: October 2020

AbstractAccumulating evidence indicates that a considerable number of antibiotics exert anti‐inflammatory and neuroprotective effects in different central and peripheral nervous system diseases including spinal cord injury (SCI). Both clinical and preclinical studies on SCI have found therapeutic effects of antibiotics from different families on SCI. These include macrolides, minocycline, β‐lactams, and dapsone, all of which have been found to improve SCI sequels and complications. These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI‐related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.
Scorpion toxin MeuNaTxα‐1 sensitizes primary nociceptors by selective modulation of voltage‐gated sodium channels
Authors: van Cann Marianne , Kuzmenkov Alexey , Isensee Jörg , Andreev‐Andrievskiy Alexander , Peigneur Steve , Khusainov Georgii , Berkut Antonina , Tytgat Jan , Vassilevski Alexander , Hucho Tim 
Published: October 2020

Venoms are a rich source of highly specific toxins, which allow the identification of novel therapeutic targets. We have now applied high content screening (HCS) microscopy to identify toxins that modulate pain sensitization signaling in primary sensory neurons of rat and elucidated the underlying mechanism. A set of venoms and fractions thereof were analyzed for their ability to activate type II protein kinase A (PKA‐II) and extracellular signal‐regulated kinases (ERK1/2). We identified MeuNaTxα‐1, a sodium channel‐selective scorpion α‐toxin from Mesobuthus eupeus, which affected both PKA‐II and ERK1/2. Recombinant MeuNaTxα‐1 showed identical activity to the native toxin on mammalian voltage‐gated sodium channels expressed in Xenopus laevis oocytes and induced thermal hyperalgesia in adult mice. The effect of MeuNaTxα‐1 on sensory neurons was dose‐dependent and tetrodotoxin‐sensitive. Application of inhibitors and toxin mutants with altered sodium channel selectivity demonstrated that signaling activation in sensory neurons depends on NaV1.2 isoform. Accordingly, the toxin was more potent in neurons from newborn rats, where NaV1.2 is expressed at a higher level. Our results demonstrate that HCS microscopy‐based monitoring of intracellular signaling is a novel and powerful tool to identify and characterize venoms and their toxins affecting sensory neurons.
Resilience of Spanish forests to recent droughts and climate change
Authors: Khoury Sacha , Coomes David A. 
Published: October 2020

AbstractA widespread increase in forest cover is underway in northern Mediterranean forests because of land abandonment and decreased wood demand, but the resilience of these successional forests to climate change remains unresolved. Here we use 18‐year time series of canopy greenness derived from satellite imagery (NDVI) to evaluate the impacts of climate change on Spain's forests. Specifically, we analyzed how NDVI was influenced by the climatic water balance (i.e. Standardized Precipitation‐Evapotranspiration Index, SPEI), using monthly time‐series extracted from 3,100 pixels of forest, categorized into ten forest types. The forests increased in leaf area index by 0.01 per year on average (from 1.7 in 2000 to 1.9 in 2017) but there was enormous variation among years related to climatic water balance. Forest types varied in response to drought events: those dominated by drought‐avoiding species showed strong covariance between greenness and SPEI, while those dominated by drought‐tolerant species showed weak covariance. Native forests usually recovered more than 80% of greenness within the 18 months and the remainder within 5 years, but plantations ofEucalyptuswere less resilient. Management to increase the resilience of forests—a key goal of forestry in the Mediterranean region—appears to have had a positive effect: canopy greenness within protected forests was more resilient to drought than within non‐protected forests. In conclusion, many of Spain's successional forests have been resilient to drought over the past 18 years, from the perspective of space. Future studies will need to combine remote sensing with field‐based analyses of physiological tolerances and mortality processes to understand how Mediterranean forests will respond to the rapid climate change predicted for this region in the coming decades.
Antibacterial applications and safety issues of silica‐based materials: A review
Authors: Tian Bingren , Liu Yumei 
Published: October 2020

AbstractAs the problem of bacterial contamination continues to grow in its significance, researchers have reported many antibacterial materials that are based on inorganic compounds. Of these, materials that are based on silica and its derivatives have been widely used in engineering, medicine, and food. This paper reviews the advantages, safety issues, and applications of silica and its derivatives, as reported in recent years. The information provided highlights the preparation, application, and antimicrobial efficiency of materials that are based on silica and have different structure/size. We outline the possible antimicrobial mechanisms of silica‐based materials and the potential challenges that researchers may face. With a focus on increasing concerns regarding bacterial contamination in the food and medical industries, we have also proposed corresponding antibacterial material preparation strategies.