bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stigma in Family Patients Who Have a Psychiatric Disorder: A Systematic Review
Authors: Reong Antonia Rensiana , Astuti Retno Puji 
Published: March 2020

Introduction: The stigma in families who are caring for patients who experience mental illness in the modern era is high. Some of the experiences of patients with mental illness reveal that they are still stigmatized. This is not just the patients but also the families that care for them. The aim of this study was to conduct a systematic review relating to the stigma felt by the families of the patients experiencing mental illness.Methods: The database used to identify the potential articles was Scopus. The articles were limited to a range of 5 years from 2014 through to 2018. The keywords used in the literature review were "Stigma Family" And "Mental illness".Results: Fifteen articles from eight countries were evaluated. The families were confirmed as experiencing stigma: labeling, stereotyping, separation and discrimination. Stigma means that the families face psychological, social and intrapersonal consequences which can reduce the family quality of life and family functioning.Conclusion: There are opportunities for negative outcomes related to the family resilience. One of the results of the study revealed that psycho-education programs using education interventions can be an alternative intervention to reduce stigma.
Summary of the Prevention of Catheter-Associated Urinary Tract Infection in An Intensive Care Unit
Authors: Waluyo Waluyo , Permata Yulia Indah , Rohmah Ulfa Nur , Andini Saskiyanti Ari 
Published: March 2020

Background: Catheter-associated urinary tract infection is the most common type of nosocomial infection in an intensive care unit. The aim of this study was to examine the existing evidence of preventative measures against catheter-associated urinary tract infection being implemented to reduce urinary tract infection in intensive care units.Method: Databases were used to identify potential articles, namely Scopus, Pubmed, EBSCO and Proquest, limited to those published within the last 5 years from 2013 to 2018. The literature review used the keyword prevention, CAUTI and ICU. In the article search using “AND”, only 14 studies met the inclusion criteria. Across the 14 studies, 42486 participants and a mean 3540 per trial were included.Discussion: Nursing round, CAUTI bundle, bacitracin and cranberry, Nurse-driven protocol, protocol by team/ developmental protocol, surveillance of CAUTI, education, performance feedback, and general cultural practices alongside the American College of Critical Care Medicine and the Infectious Disease Society of America present guidelines that recommend CAUTI preventive practices that can be implemented to reduce the incidence of CAUTI in ICUs.Conclusion: From the several strategies used to prevent CAUTI, the most effective is the multidimensional approach because this approach combines several interventions and it also involves other practitioners. A multidimensional approach is more effective than a single dimensional approach in ICU.
Trends of Early Marriage in Developing Countries: A Systematic Review
Authors: Suhariyati Suhariyati , Haryanto Joni , Probowati Ririn 
Published: March 2020

Background: Early marriage is being increasingly recognized globally as a fundamental violation of human rights and a major obstacle to sustainable development. Early marriage occurs globally to varying degrees, especially in developing countries. The purpose of this article was to identify the determinants and impact of early marriage in developing countries.Method: A systematic search for studies published from 2014 up to 2019 was conducted via Scopus, Proquest, Elsevier, Science Direct, Sage Journal, SpringerLink and EBSCO. A total of 10 studies met the inclusion criteria. These were independently extracted by two reviewers.Result: Education and place of residence were the most commonly studied determinants of early marriage. Only a few of them reported results concerning the age difference between the spouses, access to media information and self-efficiency. Early marriage has a relationship with both the mother's and child's health. However, the significance of these associations was often small or inconsistent.Conclusion: This review summarizes the best available evidence for local policymakers and public health practitioners so then they can consider incorporating these findings into the development of intervention protocols for the prevention of early marriage.
Strategy Intervention to Prevent and Reduce Postpartum Depression: A Systematic Review
Authors: Budiman M. Elyas Arif , Sari Supiah Ningsih Juita , Kusumawardani Winda , Sutopo Dhona 
Published: March 2020

Background: Postpartum depression is a non-psychotic depressive disorder with the criteria for diagnosis being that it can start early at four weeks postpartum. This can occur in the first year postpartum. Postpartum depression can result in deep sorrow and even the risk of suicide.Method: The sources of the articles used were from a search of the Scopus, PubMed and Proquest databases with the keywords “postpartum depression, nursing intervention, psychology and postpartum”. The search was restricted articles ranging from 2014 until 2018. After the articles were obtained, then the articles were reviewed until the stage of making a systematic review.Result: The systematic review resulted in 15 of 19 choices of interventions that can be used to prevent and reduce the symptoms of postpartum depression. The results found that an internet cognitive behavior therapy intervention is very significant in terms of preventing and reducing the symptoms of postpartum depression. Nursing interventions are packaged in a variety of programs proven to reduce the postpartum depression variables and actions needed to prevent and reduce the symptoms of postpartum depression significantly.Conclusion: Based on the results of the analysis of the 15 journals from the results of the study, internet cognitive behavior therapy intervention is recommended to prevent and reduce postpartum depression. This intervention can be developed practically and easily.
The Impact of Hospital Accreditation on Nurses' Perceptions of Quality of Care?
Authors: Trisno Tejo , Putra Agit Pratama , Purwanza Sena W 
Published: March 2020

Introduction: Accreditation is the recognition of the quality of services that have met the National Hospital Accreditation Standards. In implementing hospital accreditation , it covers patient safety goals, patient-focused service standards, hospital management standards, national programs and integration of health education in hospital services. How is the impact of hospital accreditation on the quality of care, especially nursing services in accordance with the perceptions and attitudes of nurses in hospitals. Therefore, it is necessary to identify the impact of applying hospital accreditation in accordance with nurses' perceptions and attitudes towards nursing services. Methods: For this reason, articles data with a for publication from 2008-2018 are needed, of the 418 systematic literature articles taken from Scopus, Science direct, and Proquest. There are 15 articles chosen to search for literature with keywords; the impact of accreditation on nurses' perceptions and attitudes about the quality of care.Results: Five of the 15 articles that fit the design criteria that address the impact of hospital accreditation according to nurses' perceptions and attitudes in improving nursing services.Conclusion: The study results show that hospital accreditation make a nurses perception the quality of care. Quality of care is the one of impact from hospitals accreditation. Nurses in accredited hospitals feel a higher level of quality of health services.
Endogenous endophthalmitis caused by group B streptococcus; case reports and review of 35 reported cases
Authors: Yoshida Masaaki , Yokokura Shunji , Nishida Takashi , Mochizuki Kiyofumi , Suzuki Takashi , Maruyama Kazuichi , Otomo Takaaki , Nishiguchi Koji M , Kunikata Hiroshi , Nakazawa Toru 
Published: March 2020

Abstract

Background:Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE). However, the number of invasive GBS infections is increasing, particularly in elderly patients with underlying conditions such as diabetes mellitus (DM), cardiovascular disease and cancer. We report 6 cases of EBE caused by GBS and review the literature.Methods:Retrospective case series and literature reviewResults:In the current case series, 6 eyes of 6 patients developed EBE caused by GBS. The average age was 73.5 years. The focus of infection included the urinary tract, cellulitis, arthritis, peritonitis, catheter-associated infection and endocarditis. Four patients had DM. While all 6 strains were sensitive to β-lactams (penicillins and cephems), 4 strains were resistant to levofloxacin (no data for 1 isolate). Each case was treated with the systemic antibiotic to which the individual strain was sensitive. All cases showed poor visual acuity at presentation (decimal visual acuity: less than 0.03). Vitrectomy with intravitreal antibiotics injection was performed in 4 cases. Visual acuity recovered in 4 cases and did not recover in 2 cases, even after vitrectomy. The literature review of 53 eyes of 41 patients revealed that 60% of eyes finally lost all vision, and death occurred in 2 cases. Initial visual acuity of less than counting fingers was associated with a final outcome of lost vision. Of 41 patients, 13 (32%) had DM as an underlying medical condition. The most common extra-ocular infection focus was endocarditis (37%).Conclusions:DM is common in patients with EBE caused by GBS. While the 4 cases in the current report had a relatively good visual acuity outcome, despite poor initial visual acuity, the literature review indicated that EBE caused by GBS is generally a severe condition with a poor prognosis. The current study also indicates the importance of considering the possibility of endocarditis on encountering EBE caused by GBS.
Clinical significance of CRP and IL-6 levels during the perioperative period of hip arthroplasty for aged patients with femoral neck fractures
Authors: Zhao Fulong , Guo Lijuan , wang xuefei , Zhang Yakui 
Published: March 2020

Abstract
Background To analyze and explore the clinical significance of changes in C-reactive protein (CRP) and interleukin-6 (IL-6) levels during the perioperative period in older patients that underwent hip arthroplasty for femoral neck fractures. Methods This retrospective study analyzed data for 82 patients that underwent hip arthroplasty for femoral neck fractures from June 2018 to June 2019in our hospital, Of these, 39 patients underwent hemiarthroplasty (HA) and 43 underwent total hip arthroplasty (THA). CRP and IL-6 were measured before the operation (baseline) and on the 1 st , 2 nd , 3 rd , and 7 th day after hip arthroplasty. Comparisons between groups were performed with the t test and χ 2 test. Results Post-operative serum CRP and IL-6levels showed a trend of first increasing, then decreasing, but all levels were higher than baseline. The serum CRP level peaked on the third post-operative day, and IL-6 peaked on the first post-operative day. We found no significant difference in CRP or IL-6 levels between patients that received HAs and patients that received THAs. Conclusion We showed a trend in CRP and IL-6 changes during the perioperative period. These findings suggested that CRP and IL-6 might be involved in the early inflammatory response. Thus, both CRP and IL-6 levels might be useful for evaluating the postoperative inflammatory response in older patients with femoral neck fractures that undergo hip arthroplasty.
Myeloproliferative neoplasm with ETV6-ABL rearrangement conferred a granulocyte proliferation bias
Authors: Chen Yuan , Liu Qian , Li Yan , Wei Hui , Rao Qing , Wang Min , Wang Jianxiang 
Published: March 2020

Abstract
Background: ETV6-ABL (TEL-ABL) fusion gene is a rare but recurrent genetic aberration found in hematologic malignancies including myeloproliferative neoplasm, acute myeloid leukemia and acute lymphoblastic leukemia. As a infrequent fusion gene, there is no special treatment guideline for the diseases it causes. Methods: A case of a 42-year old man was reported, who presented fever with a markedly leukocytosis and CML-like marrow without BCR-ABL. Fusion gene was detected by RT-PCR and confirmed by direct sequencing. ETV6-ABL mRNA expressions in each cell population were determined by real-time RT-PCR in sorted peripheral blood cells. Results: ETV6-ABL fusion gene was detected by RT-PCR in the bone marrow cells. The type A of ETV6-ABL was confirmed by direct sequencing. The ratio of ETV6-ABL fusion gene transcript level in polymorphonuclear was nearly 3.6 relative to total cells, which was significantly higher than other cells. His blood routine returned to normal after three months of treatment with imatinib at 400mg daily dose. After 6 months for TKI treatment, the ratio of ETV6-ABL/ABL decreased from 174.1% to 1.882%. Conclusion: ETV6-ABL fusion gene conferred a granulocyte proliferation bias and responded to TKI therapy.
Assessment and forecasting the spread of SARS-CoV-2 outbreak in Changsha, China: Based on a SEIAR Dynamic Model
Authors: Zha Wenting , Zhou Nan , Li Guoqun , Li Weitong , Zhang Heng , Zhang Siyu , Chen Mengxiang , Feng Ruihua , Li Tong , LV Yuan 
Published: March 2020

Abstract
Background: A new human coronavirus named SARS-CoV-2 emerged during December 2019 in Wuhan, China. Cases have been exported to other Chinese cities and abroad, which may cause the global outbreak. Chang Sha is the nearest provincial capital city to Wuhan, the first case of COVID-19 in Changsha was diagnosed on January 21, 2020. Estimating the transmissibility and forecasting the trend of the outbreak of SARS-CoV-2 under the prevention and control measures in Changsha could inform evidence based decisions to policy makers.
Methods: Data were collected from the Health Commission of Changsha and Hunan Center for Disease Control and Prevention. A Susceptible-exposed-infections/ asymptomatic- removed (SEIAR) model was established to simulate the transmission of SARS-CoV-2 in Changsha. Berkeley Madonna 8.3.18 were employed for the model simulation and prediction, while the curve fitting problem was solved by the Runge-Kutta fourth-order method, with a tolerance of 0.001.
Results: In this study, we found that Rt was 2.05 from January 21 to 27 and reduced to 0.2 after January 27, 2020 in Changsha. The prediction results showed that when no obvious prevention and control measures were applied, the total number of patients in Changsha would reach the maximum (2.27 million) on the 79th day after the outbreak, and end in about 240 days; When measures have not been fully launched, the total number of patients would reach the maximum (1.60 million) on the 28th day after the outbreak, and end in about 110 days; When measures have been fully launched, the total number of patients would reach the maximum (234) on the 23rd day after the outbreak, and end in about 60 days.
Conclusions: Outbreak of SARS-CoV-2 in Changsha is in a controllable stage under current prevention and control measures, it is predicted that the cumulative patients would reach the maximum of 234 on February 12, and the outbreak would be over on 20 March in Changsha. With the fully implementation of prevention and control measures, it could effectively reduce the peak value, short the time to peak and duration of the outbreak.
How many digits after decimal point are needed to use SUVmax as an identifier of tumors on FDG PET-CT?
Authors: Hirata Kenji , Manabe Osamu , Magota Keiichi , Furuya Sho , Shiga Tohru , Kudo Kohsuke 
Published: March 2020

Abstract
Purpose The maximum standardized uptake value (SUVmax) is often described in daily clinical reports of FDG PET-CT. We investigated whether it would be possible to localize the voxel automatically based on the SUVmax. Methods The institutional review board approved this retrospective study. We investigated a total of 112 lesions from 30 FDG PET-CT images acquired with 3 different scanners. The number of voxels showing the given SUVmax was counted, where SUVmax was provided with various degrees of precision, such as 3, 3.1, 3.14, 3.142. The effects of local maximum restriction, where only local maximum voxels were chosen, were evaluated. Results SUVmax ranged from 1.3 to 49.1 (median = 5.6, IQR = 5.2). Generally, when larger and more precise SUVmax values were given, fewer voxels were included in the range. The local maximum restriction was very effective. When SUVmax was determined to 4 decimal places (e.g., 3.1416) and the local maximum restriction was applied, 33.3% (lesions with SUVmax<2), 79.5% (2≤SUVmax<5), and 97.8% of lesions (5≤SUVmax) were successfully identified (i.e., only a single voxel satisfied the criteria). Conclusions In FDG PET-CT, SUVmax can be used to localize the lesion if a large and precise SUVmax is provided.
Testing of primary stability of the Activ® L intervertebral disc prosthesis in cadaver bone and comparison of the two different anchoring concepts – keel and spike anchoring
Authors: Pellengahr Christoph von Schulze , Teske Wolfram , Kapoor Saurabh , Klein Alexander , Wegener Bernd , Büttner Andreas , Lahner Matthias 
Published: March 2020

Abstract
Background: High primary stability is the fundamental prerequisite for safe osseointegration of cementless intervertebral disc prosthesis. The aim of our study was to determine the primary stability of intervertebral disc prosthesis with two different anchoring concepts – keel and spike anchoring. Methods: 10 human cadaveric lumbar spine specimens with an ActivL intervertebral disc prosthesis (5 x keel anchoring, 5 x spike anchoring) were tested on a spine simulator. Under axial load, moments of flexion, extension, left and right bending and axial rotation were applied on the lumbar spine specimens through a defined three-dimensional movement program as per ISO 2631 and ISO/CD 18192-1.3 standards. Micro-motion of the implant was measured in every axis for both anchor types and compared using statistical test for significance after calculating 95% confidence intervals. Results: In the transverse axis, the keel anchoring concept showed lower mean values of micro-motion , which was statistically significant (p<0.05) compared to spike anchoring concept. In the sagittal axis, the results were again in favour of the keel anchoring, but did not reach statistical significance (p>0.05). The highest micro-motion values were observed in the longitudinal axis. Both concepts showed values around the threshold of primary stability (150 μm) with the spike concept showing lower mean values, but without a statistically significant difference.Conclusions: Both types of anchors met the criteria of primary stability. The keel anchoring shows a slight advantage compared to anchoring with spikes. Direct postoperative active mobilization doesn’t seem to compromise the primary stability of the prosthesis.
Intensive versus non-intensive statin pretreatment before percutaneous coronary intervention in Chinese patients: a meta-analysis of randomized controlled trials
Authors: Yang Xian , Lan Xi , Zhang Xin-Lin , Han Zhong-Lin , Yan Si-Min , Wang Wen-Xiao , Xu Biao , Ge Wei-Hong 
Published: March 2020

Abstract
Background: Studies of intensive statin pretreatment before percutaneous coronary intervention (PCI) was very limited in Chinese and there were no corresponding meta-analysis involving hard clinical endpoints has been published so far. Therefore, the guidelines did not give a positive recommendation, which was inconsistent with Western people. The aim of this study was to evaluate the efficacy and safety of high-dose statin loading before PCI in Chinese patients through meta-analysis.Method: Relevant studies were identified via search of electronic databases of PubMed, Embase, and Cochrane’s Library to December 2019. The outcomes included major adverse cardiovascular event (MACE), nonfatal myocardial infarction(MI), cardiac death, target vessel revascularization (TVR), myalgia/myasthenia and abnormal alanine aminotransferase (ALT) in all enrolled patients were assessed.Results: 12 studies involving 3183 individuals were included in this review．The results showed different from cardiac death and TVR, the incidence of MACE ( RR =0.49, 95% CI : 0.30 to 0.80, P =0.004, I 2 =63%) and nonfatal MI ( RR =0.54, 95% CI : 0.33~ 0.88, P = 0.01, I 2 =62%) between intensive statin and non-intensive statin treatment group were statistically significant. The subgroup analysis further suggested the benefits of different treatment were not consistent. Compared with the preoperative intensive statin therapy, the incidence of MACE and nonfatal MI were significantly elevated in patients receiving placebo or no statin treatment before surgery（ RR =0.47, 95% CI : 0.34～0.65, P <0.00001, I 2 =0%; RR =0.49, 95% CI : 0.35～0.70, P <0.0001, I 2 =0%）. However, the incidence of MACE and nonfatal MI were not statistically significant compared preoperative high-intensity statin therapy with moderate-intensity statin therapy（ RR =0.96, 95% CI : 0.44～2.08, P =0.91, I 2 =11%; RR =1.10, 95% CI : 0.86～1.39, P =0.44）. Besides, The study also demonstrated Asian population were able to tolerate high-intensity atorvastatin during the perioperative period.Conclusion: Compared with placebo or no statin pretreatment, Chinese patients received intensive statin before PCI can further reduce the incidence of MACE and nonfatal myocardial infarction. However there was no significant benefit between high-intensity and moderate-intensity statin. In addition, the Chinese population was well tolerated by preoperative intensive statin pretretment.
Magnitude of anemia and its associated factors among adult patients with HIV/AIDS on anti-retroviral therapy at Jinka town public health facilities, South Omo zone, Southern Ethiopia; cross-sectional study
Authors: Dessu Samuel , Sisay Yordanos , Girma Meseret , Zerihun Eshetu 
Published: March 2020

Abstract
Background: Anemia is Public health problem in persons living with Human immune virus/acquired immune deficiency syndrome particularly in peoples taking antiretroviral therapy. It has effect on their quality of life and disease progression to acquired immune deficiency syndrome (AIDS). Studies regarding anemia among Human immune virus/acquired immune deficiency syndrome (HIV/AIDS) patients taking antiretroviral therapy (ART) and its associated factors are scarce specifically in remote areas.Method: An institution based Cross-sectional study was employed in Jinka town public health facilities from Feb 18, 2019-March 29, 2019. Systematic random sampling method was used, and a total sample size was 422 were determined. Data was entered using Epi data version 4.4 and analyzed by using SPSS version 25 statistical software. Variables which had a p-value ≤ 0.25 in bivariate analysis were considered as candidates for multivariable regression analysis and variables which had a p-value of ≤0.05 in the multivariable analysis were considered as statistically significant.Result: The overall magnitude of anemia was 33.5 %( 95%CI: 28.8, 38.1). Multivariable analysis showed that unable to read and write (AOR:4.3; 95%CI:1.56,11.96), AZT users(AOR:3.0;95%CI:1.73,5.36), CD4 count less than 200 cells/mm3 (AOR:3.6;95%CI:1.63,8.09) and history of opportunistic infection (AOR:4.3; 95%CI:2.43,7.68) were significantly associated with the occurrence of anemia.Conclusion: More than one third of study participants were anemic. Unable to read and write, AZT users, CD4 count less than 200cells/mm3 and history of opportunistic infection were significantly associated with anemia.