bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Value of Inflammatory and Nutritional Markers for Hepatocellular Carcinoma
Authors: Xu Yingying , Yuan Xiuxue , Yao Longdi , Zhang Xiaomin , Zong Liang 
Published: December 2020

Abstract
Background: It is well known that the prognosis of cancer patients after tumor resection is closely related to the patient's autoimmune ability and nutritional status. A large number of studies have shown that the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and Onodera's prognostic nutritional index (OPNI) are significantly correlated with the prognosis of various tumors. In this study, we analyzed the prognostic value of NLR, PLR and OPNI for hepatocellular carcinoma (HCC) for the first time.Patients and Methods: Data of hepatocellular carcinoma patients undergoing hepatectomy in Changzhi People’s Hospital (Changzhi, China) from 2011 to 2017 were retrospectively analyzed. A total of 286 patients with hepatocellular carcinoma were included in the analysis. The Optimum cut-off values of OPNI, NLR and PLR were determined by using the X-tile program. The overall survival (OS) was analyzed by Kaplan-Meier method and verified by log-rank test. Multivariate analysis was performed using Cox Proportional Hazard Regression model to determine independent prognostic indicators for HCC.Results: Univariate and multivariate analysis showed that OPNI (p<0.001), Treatment (Surgery, p=0.04; Interventional therapy, p=0.002), Postoperative treatment (YES, p=0.004) and Stage can be used as independent prognostic maker for HCC. Comparing the P values and hazard ratios, we found out that the OPNI has greatest influence on prognosis in these preoperative indexes. The optimal cut-off values of NLR, PLR and OPNI were 2.5, 133.3 and 39.5, respectively. Compared with the low OPNI group, the high OPNI group had a better prognosis. In the correlation analysis between OPNI and clinicopathological features, only Age and NLR showed statistical differences, while others did not.Conclusions: OPNI can be used as a simple and effective independent prognostic marker for hepatocellular carcinoma.
Estimating Disability Weight of Human Neurocysticercosis in Dali, Yunnan province, China
Authors: Zang Xinzhong , Li Huanzhang , Qian Menbao , Chen Yingdan , Zhou Changhai , Liu Hongkun , Liu Yuhua , Qian Yingjun , Li Shizhu 
Published: December 2020

Abstract
BackgroundHuman cysticercosis, caused by the liver parasite Taenia solium, remains an important neglected tropical disease in China. In Yunnan province, a large proportion of in-patients with cysticercosis suffer from neurocysticercosis. Neurocysticercosis, though preventable, is a cause of epilepsy globally. Disability weight is an important parameter when estimating neurocysticercosis disease burden and assessing disability-adjusted life years. However, there is a paucity of information on disability weight in patients with neurocysticercosis.MethodsParticipants were separated into 2 groups and were interviewed by EQ-5D+C questionnaire in Dali prefecture, Yunnan province. Statistical analysis was performed using SPSS 20.0.ResultsCompared to those in the first-visit group, health barriers were less frequently reported in all six dimensions in the follow-up group, except for the cognitive dimension. Disability weights in both the first-visit and follow-up groups were 0.3.ConclusionsThe health-related quality of life of NCC patients was seriously impaired, and cognitive competence is the most prominent health barrier. Psychological medical care should be taken as one component in the treatment of NCC patients.
Cervical Cancer Screening Practice and Associated Factors Among Women Employees in Wolaita Zone Hospitals, Southern Ethiopia, 2017
Authors: TESFAYE GETACHEW , ASFAW SHIFERA , ABERA MILLION , LAKEW MIHRET , WODAYNEW TILAHUN , MAMO ABEBE 
Published: December 2020

Abstract
Background: Cervical cancer is a global public health problem accounting for the fourth most common cancer-affecting women worldwide with 527,624 women are diagnosed with cervical cancer and 265,672 die from the disease annually worldwide. Cervical cancer screening offers protective benefits and is associated with a reduction in the incidence of invasive cervical cancer and cervical cancer mortality. But there is very low participation rate in screening practice for cervical cancer in low-resource countries like Ethiopia. So the aims of this study is to assess cervical cancer screening practice and associated factors among women employees in Wolaita Zone hospitals, southern Ethiopia, 2017Methods: Facility based cross-sectional study design was conducted among age eligible women employees in Wolaita zone hospitals from March 1 -April 30, 2017. Sample size was allocated using probability proportionate allocation and finally simple random sampling technique was employed to select 401 study participants. Pre-tested semi-structured self-administered questionnaire was used. Data was entered and cleaned using Epi-data3.1 and analyzed using SPSS version 21. Logistic regression was performed to assess association between dependent and independent variables with 95% CI and p- value less than 0.05 was set to declare association.Results: About 120(30.5%) participants were screened for cervical cancer. Age (AOR=2.842(1.616, 5.00)), source of information from health professions, (AOR=3.301(1.899, 5.737)), being adherence supporter, (AOR= 3.741(1.414,9.899)),sex with more than one partner,(AOR=2.289(1.116,4.362) ,STI(AOR=3.13(1.784,5.493), increase in attitude score towards cervical cancer screening (AOR=1.468(1.334, 1.616)), increase in knowledge score (AOR=1.267(1.92, 1.346)) were significant predictors of cervical cancer screening practice.Conclusion: Magnitude of cervical cancer screening practice among age eligible women is still low. Age of the women, being adherence supporter, and source of information from health care professionals, history of multiple sexual partners, sexually transmitted disease, Knowledge and attitude were important predictors of cervical cancer screening practice. Hospitals in collaboration with town administration should put priority on cervical cancer prevention by establishing cervical cancer screening campaign.
Network Pharmacology Integrated Molecular Docking Reveals the Mechanism of Zhongfeng Xingnao Formula against Intracerebral Hemorrhage
Authors: Wan Can , Zhou Ziyi , Lu Yun , Zhang Guangyao , Cai Yefeng , Guo Jianwen 
Published: December 2020

Abstract
Background: Previous studies have shown that Zhongfeng Xingnao Formula (ZXF) can effectively reduce the mortality of intracerebral hemorrhage (ICH), but the underlying mechanism of the treatment remained still unexplored. This study aimed to expound the potential mechanism of ZXF in the treatment of ICH through network pharmacology and molecular docking.Methods: The putative targets of ZXF were obtained from the TCMSP and Uniprot database, while the potential targets of ICH received from Drugbank, Genecards and OMIM database. Then through the Venn 2.1, the overlapping targets of disease and drug were gotten for the further study. The GO and KEGG enrichment analyses were performed by R version 4.0.2 software so that the signaling pathway was acquired to the subsequent analysis. Cytoscape was used to construct the drug-compound-target-pathway network and String was utilized for the protein-protein interaction network. What’s more, the interaction between compound and target was verified by the AutoDockTools and Autodock Vina. Results: There were a total of 166 ZXF-related targets and 1258 ICH-related targets obtained from the public databases. And 87 potential targets were both related to drug and disease. The GO enrichment analysis mainly involved receptor ligand activity, signaling receptor activator activity, and cytokine receptor binding, while the signaling pathway, such as Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, PI3K-Akt signaling pathway, were significantly enriched in the KEGG enrichment analysis. The molecular docking elucidated that the aloe-emodin, beta-sitosterol, quercetin could bound well to the top five targets sorted by degree value.Conclusions: ZXF treated ICH through multiple compounds, multiple targets, and multiple pathways. The underlying mechanism of the treatment may be promoting angiogenesis, anti-inflammatory, anti-oxidative stress, and reversing atherosclerosis, which is of great significance for the treatment of ICH.
Box Girder Construction on Toll Road Project use&nbsp;Manual Program Evaluation and Review Technique (M-PERT) and Value Engineering (VE) to Performance Cost and Time Improvement
Authors: Husin Albert Eddy , Rahmawati Diah Ika , Meisaroh Myrna , Kussumardianadewi Bernadette Detty 
Published: December 2020

Abstract
Indonesia's ranking is 72 out of 141 countries and is in 5th place in the group of countries in Southeast Asia based on the 2019 Global Competitiveness Index (GCI) by the World Economic Forum. The current development of infrastructure development is not directly proportional to an increase in the number of infrastructure users by 1.9% from an annual increase of 10%-55%. And the occurrence of implementation time experienced a delay of 11.95%. And with a low rate of return on books with high investment costs in the construction of 7.79%. The expected goal in this research is to have cost and time efficiency in implementing infrastructure development. In this study, the focus is on the upper structure work, one of which is the box girder, to improve time and cost efficiency based on the Manual Program Evaluation and Review Technique (M-PERT) and Value Engineering (VE) in the case study of this research. The case study using the M-PERT method resulted in a time efficiency value of 98.87% of the completion time at the job site, while the VE method obtained an added value of income outside toll roads of 9.38% of construction costs.
The Association between Pre-Pregnancy BMI, Gestational Weight Gain and Pregnancy Outcomes: A Retrospective Cohort Study in Ahvaz, Iran
Authors: Angali Kambiz Ahmadi , Azhdari Maryam , Cheraghi Maria , shahri parvin , salmanzadeh shokrolah , borazjani fatemeh 
Published: December 2020

Abstract
Background: Maternal body mass index and maternal gestational weight gain can have positive effects on birth and maternal outcomes. We aimed to identify the effect of pre-pregnancy weight and gestational weight gain on birth outcomes.Methods: Data of this retrospective cohort study were extracted using the 1457 out of 1800 pair health records belonged to the pregnant mother and infant at Ahvaz health care centers, from 2010 to 2018.Result: The 3.18-fold increased risk for large for gestational age in overweight mothers, and a 2.9 fold increased risk for small for gestational age in those mothers with gestational weight gain below the guidelines. An increased risk of large for gestational age, low birth weight, and macrosomia were observed in overweight mothers with gestational weight gain out of the guidelines. The increased association was found between the maternal pre-body mass index and fasting blood sugar (p = 0.0001). Hence, hyperglycemia is related to a 3.58-fold incidence of macrosomia. Conclusion: Therefore, conducting more educational programs of lifestyle intervention with respect to reproductive health care is required for all women in childbearing age (before and during pregnancy), with the purpose of reducing the adverse pregnancy outcome.
Lemierre’s Syndrome: A Thing of the Past?
Authors: Dhaduk Nehal , Vedula Sudeepti , Govindan Aparna , Kalyoussef Evelyne 
Published: December 2020

Abstract
Introduction: Lemierre’s syndrome (LS), infectious thrombophlebitis of the internal jugular vein, is a rare, life-threatening complication of oropharyngeal infections underrepresented in literature. We reviewed the etiology, clinical characteristics, treatment regiments and prognosis of LS in pediatric patients.Methods: PubMed and MEDLINE were searched from February 10, 2018 to July 28, 2018 for relevant studies. A systematic review was performed using the terms LS and pediatric case. Our criteria included reviews, case reports, and case series with patients under 18 years with a diagnosis of LS. Results: 70 cases of pediatric LS were identified. The male to female ratio was 1:1.7 with an average age of 10.7 years (5 weeks to 17 years). The most common initial clinical presentations were fever (90.0%), sore throat (38.6%), and neck pain or tenderness (35.7%), while the most frequent findings on physical exam were fever (31.4%) and neck involvement (28.6%). F. necrophorum was the predominant organism cultured (62.9%). Septic emboli were seen in 51.4% of cases with the lungs affected in 40 patients. Most commonly used treatments were antibiotics (91.4%) followed by anticoagulation (50.0%) and the overall mortality rate was 8.6%. The average time from initial presentation to diagnosis was 4.9 days. Conclusion: LS is a deadly condition with a staggering mortality rate despite the advent of antibiotic measures. Early identification and a high index of suspicion are necessary to prevent complications associated with LS. Despite its rarity it should remain on the differential for any patient with toxic signs and localized neck findings.
Eradication of Helicobacter Pylori Improves Dyspepsia Symptoms in Elderly People
Authors: Tanaka Ikko , Ono Shoko , Shimoda Yoshihiko , Inoue Masaki , Kinowaki Sayoko , Tsuda Momoko , Ono Masayoshi , Yamamoto Keiko , Shimizu Yuichi , Kato Mototsugu , Sakamoto Naoya 
Published: December 2020

Abstract
BackgroundTherapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. AimsTo evaluate the outcomes of eradication therapy and effects of eradication on dyspepsia symptoms in elderly patients.MethodsThis retrospective study included 496 patients who received H. pylori eradication therapy. The patients were divided into a group of elderly patients (group E: ≧ 65 years old) and a group of non-elderly patients (group N: < 65 years old). Abdominal symptoms were evaluated using a questionnaire about 12 abdominal symptoms before eradication and after eradication (1-2 months and more than one year). Dyspepsia was defined as a score of 4 points or more score for at least one of 4 items (postprandial fullness, early satiety, epigastric pain, and hunger pain).ResultsSuccesful H. pylori eradication rate in group E was significantly lower than that in group N (74.7 % vs. 84.4 %, P < 0.05) and it was remarkable in the 3rd-line therapy (59.7 % vs. 76.5 %, P < 0.05). Serious adverse events did not occur in either groups. Successful eradication improved symptoms in patients with dyspepsia in both groups within 2 months (70.3% of the patients in group N, 76.2% of the patients in group E) and decrease of GOS score lasted for more than 1 year.ConclusionsH. pylori eradication would be recommend for elderly patients with dyspepsia symptoms.
The Simple Maneuver to Safely Extend the Anhepatic Time to 30 Minutes for Rat Liver Transplantation
Authors: Tang Gaofeng , Zhang Jiabin , Zhao Huibo , Wei Sidong , zhou shaotang , Chen Guoyong 
Published: December 2020

Abstract
Background: Orthotopic rat liver transplantation (OLT) is widely used; it remains to be challenging although many renovations have been made. Methods: For tolerance induction, we performed OLT including whole graft OLT from close Sprague Dawley (SD) rat to SD (whole graft group, control group, n=21) and 30 minute anhepatic time (AHT) group (AHT group, n=11). For good outcomes of AHT group and generalization of this maneuver, partial OLT was performed from 50% Lewis allograft to Brown Norway (BN) rats to induce tolerance (half graft group, n=28), Cyclosporine A was injected once daily for 14 days. Results: For whole graft group, 30-day survival rate was 85.5% (18/21), the reasons of death were gas embolism due to the missed suturing in 2 cases, blood loss in 1 case. For AHT group and tolerance group, 30-day survival rate was 72.7% (8/11), 64.3% (18/28), the causes of death were diverse. There were no differences in survival in 3 groups (p=0.289). Conclusion: The anhepatic time can be extended simply through the change of clamping the diaphragm, which facilitates its application in the research.
The Management of Portal Vein Thrombosis after Adult Liver Transplantation: A Case Series and Review of the Literature
Authors: Li Qingshan , Wang Wanli , Ma Tao , Wang Yue , Yang Yifan , Shi Jianhua , Tian Min , Liu Xuemin , Zhang Xiaogang , Lv Yi , Wang Bo 
Published: December 2020

Abstract
Background: Portal vein thrombosis (PVT) after adult liver transplantation (LT) is a rare but serious complication with no consensus on the ideal treatment. We report a case series and a comprehensive review of the literature on PVT after LT to discuss the therapeutic options. Methods: The clinical data of 360 adult patients (≥18 years of age) that underwent LT from January 2015 to January 2018 were reviewed, and a comprehensive search of PubMed and Web of Science was conducted. Patients diagnosed with PVT after LT were identified, and relevant risk factors and therapies were analyzed. Results: Among the 360 patients, seven (2.69%) developed PVT after LT. The onset of PVT within one week after LT was found in six patients (85.71%). Four of these seven patients with PVT received systemic anticoagulation (low molecular weight heparin and warfarin) therapy. Minimally invasive interventional therapies combined with systemic anticoagulation (heparin and warfarin) were applied to three patients, two of whom died because of severe abdominal hemorrhage and liver failure. In the 29 cases reported in the literature, minimally invasive interventional therapy combined with systematic anticoagulation or sclerotherapy were the most used methods (19/29). Systemic anticoagulation was administered to three patients, surgical operation (thrombectomy; portosystemic shunt and retransplantation) was performed for seven patients. Among these 29 patients, four eventually died. Conclusions: In conclusion, interventional therapy combined with systemic anticoagulation is a good choice for the management of PVT after LT, and in our experience, systemic anticoagulation alone can also have a positive effect for early PVT patients.
Precision and Flexible Bending Control strategy Based on Analytical Models and Data Models
Authors: Duan Yongchuan , Zhang Fangfang , Liu Yu , Qiao Haidi , Yang Liu , Guan Yingping 
Published: December 2020

Abstract
Forming of various customized bending parts, small batches, as well as numerous types of materials is a new challenges for Industry 4.0, the current control strategies can not meet the precision and flexibility requirement, expected control strategy of bending processes need to not only resist unknown interferences of process condition and models, but also produce various new parts automatically and efficiently. In this paper, a precision and flexible bending control strategy based on analytical models and data models is proposed to built adaptive bending systems. New analytical prediction models for loading and unloading are established and suitable for various materials, a sequential identification strategy is proposed to search nominal properties using the four sub-optimization models. A data-based feedback model is established to prevent over-bending and eliminate online deviation. Above models are merged into a precision and flexible control strategy. the system firstly uses sub-optimization models to search the nominal point which is near to target point, secondly the system further uses feedback model to eliminate residual error between the nominal point and target point. Compared with four kinds sheet metals, the allowable ranges for variables are determined for a good convergence. The target bending angles were set to 20°, 40°, and 60°. Forty parts were tracked for each kind material, the adaptive bending system converged after one iteration, and exhibited better performances.
Comparative Analysis of Temporal Transcriptome Reveals the Relationship Between Pectin Degradation and Pathogenicity of Defoliating Verticillium Dahliae to Upland Cotton (Gossypium Hirsutum)
Authors: Zhang Fan , Zhang Jiayi , Chen Wanqing , Liu Xinran , Li Cheng , Cao Yuefen , Zhao Tianlun , Lu Donglin , Hui Yixuan , Zhang Yi , Chen Jinhong , Zhang Jingze , Pepper Alan E. , Yu John Z. , Zhu Shuijin 
Published: December 2020

Abstract
Background: Verticillium wilt (VW), caused by Verticillium dahliae Kleb., is a major plant disease that causes heavy annual losses around the world, especially in Upland cotton (Gossypium hirsutum). The disease-causing pathogen can be classified into defoliating (D) and non-defoliating (ND) pathotypes based on the induced symptoms. At present, little is known about the complex mechanisms of fungal pathogenicity and cotton resistance to it. Comparative analysis of temporal transcriptome was performed on two V. dahliae strains, Vd_086 (D) and Vd_BP2 (ND), at key development stages (hyphal growth, microsclerotia production, and spore germination) to reveal the functional process on plant defoliation and death.Results: Differentially expressed gene (DEG) analysis revealed a strong correlation between cell wall protein kinase activities and the early pathogenicity of defoliating Vd_086. With weighted gene co-expression network analysis (WGCNA), six specific gene modules were correlated with the biological traits of the fungal samples. Functional enrichment with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways together with DEG analysis revealed six pectin degrading enzymes including Polygalacturonase gene 1 (PG1), Pectate lyase gene (PEL) and Pectinesterase gene 1 (PME1) expressed in the early development of Vd_086 that may be related to the robust pathogenicity of this strain during the early invasion. The expression of four of these genes was verified by real-time quantitative reverse transcription PCR (qRT-PCR). In addition, we identified Mitogen-Activated Protein Kinase (MAPK) signaling “hub” genes that may regulate these pectinases.Conclusions: Enhanced expression of pectin degradation enzymes is associated with the stronger pathogenicity of Vd_086 than Vd_BP2, especially at early infection stages. The disease-causing capability is likely regulated by MAPK signaling genes. This study provides new insight into molecular mechanisms of the plant-pathogen interaction on the VW disease, facilitating more effective control measures against this pathogen, including molecular breeding for the VW-resistant cotton cultivars.
Psychopathology analysis of 23 cases with COVID-19 pneumonia accompanied by abnormal brain imagine
Authors: Sun Fengli , Chen Xinsheng , Ren Hongwei , Liu Jianning , Jin Weidong 
Published: December 2020

Abstract
BackgroundCOVID-19 broke out in Wuhan, China in late 2019.the persons involved maybe influenced in psychology. Abnormality of central never system(CNS) may promote appeared more psychological symptomsin patients with COVID-19 pneumonia.MaterialsAll the cases were from the hospital where the author was located and diagnosed COVID-19 pneumonia with abnormality of cranial CT examination.ResultAll 23 patients performance mental symptoms of consciousness disturbance,cognitive impairment,anxiety and depression,sleep disorder. The more and serious mental symptoms correlated with dangerous and severe or severe type of COVID-19 pneumonia, more physical disease.ConclusionCOVID-19 pneumonia patients with cranial CT abnormality always had mental symptoms.