bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Cultural Exchange between China and South Korea on the Relations between the Two Countries in the Internet Era
Authors: Hong Sun 
Published: November 2019

Abstract
Based on a clear understanding of the current situation of cultural exchanges between China and Korea, this paper focuses on the impact of contemporary cultural exchanges on the politics, economy, trade and society of China and Korea, and then expounds the problems arising from cultural exchanges between China and Korea, as well as the measures to be taken in the face of future cultural exchanges between the two countries, so as to guide the development of Sino-Korean relations in the direction beneficial to the common interests of the two peoples, to establish a comprehensive partnership strategy between China and Korea, to promote the smooth development of Sino-Korean relations, and to bring enlightenment to better play the role of cultural exchanges in promoting the relations between the two countries in the future.
Synchronization Control of Switched Complex Networks with Additive Delays
Authors: Sun Changfan , Lu Guoping , Sheng Suying , Dai Xinglei 
Published: November 2019

Abstract
The synchronization control problem for a class of switched complex networks with additive time-varying delays is studied.Firstly,the switched complex network drive-response system for system node parameter switching is studied.The appropriate Lyapunov function is constructed under the influence of additive time delay.According to Lyapunov stability theory and inequality technique,the sufficient conditions for mean-square exponential synchronization of the system are obtained.And these conclusions are expressed by linear matrix inequality (LMI).Secondly,the matrix inequality is solved by using LMI toolbox to synchronize the master-slave system.Finally,a numerical example is given to verify the effectiveness of the proposed method.
Lyapunov function selection for saturated constrained system
Authors: Zhang Cui 
Published: November 2019

Abstract
For a nonlinear system which is not globally asymptotically stable, it is important to study its attractive domain. Saturation constrained control system is one of the most important nonlinear systems. The estimation of attractive domain of saturated constrained control system involves the selection of Lyapunov function. This paper summarizes the different Lyapunov functions in the estimation of attractive domain of saturated constrained control system and illustrates them with numerical examples.
Characterization and corrosion resistance study of the Fe–Cr films electrodeposited from trivalent chromium sulfate electrolyte
Authors: Niu Yongkang , Zhang Shasha , Cheng Qian , Zhang Zelei , Yao Zhengjun , Moliar Oleksandr 
Published: November 2019

Abstract
Fe–Cr alloy films were prepared by direct current electrodeposition using trivalent chromium sulfate electrolyte. The reaction process was clarified by cyclic voltammetry and the influence of the deposition voltage on the characteristics of the alloy was investigated by GIXRD, SEM and AFM. The chemical composition of the surface passivation film was analyzed by XPS. The corrosion performance of Fe–Cr alloy films was analyzed by Tafel polarization curves and AC impedance spectra. The results show that the electrodeposition process mainly involves the reduction process of Fe2+ and Cr3+ under glycine complexation, accompanied by hydrogen evolution reaction at high deposition voltage. The deposition voltage has obvious effect on the crystallographic structure, morphology and composition of the alloy films. Compact and uniform amorphous Fe–Cr films can be obtained at a deposition voltage of 1.9 V and the content of Cr reaches 40%. A comparison of the corrosion potential, corrosion current and polarization resistance for the deposits indicates that the Fe–Cr alloy film prepared at deposition voltage 1.9 V have superior corrosion resistance. The main chemical composition of the passivation film is Cr2O3, CrO3, which contribute to its excellent corrosion resistance.
Stress signalling dynamics of the mitochondrial electron transport chain and oxidative phosphorylation system in higher plants
Authors: Dourmap Corentin , Roque Solène , Morin Amélie , Caubrière Damien , Kerdiles Margaux , Béguin Kyllian , Perdoux Romain , Reynoud Nicolas , Bourdet Lucile , Audebert Pierre-Alexandre , Moullec Julien Le , Couée Ivan 
Published: November 2019

AbstractBackgroundMitochondria play a diversity of physiological and metabolic roles under conditions of abiotic or biotic stress. They may be directly subjected to physico-chemical constraints, and they are also involved in integrative responses to environmental stresses through their central position in cell nutrition, respiration, energy balance and biosyntheses. In plant cells, mitochondria present various biochemical peculiarities, such as cyanide-insensitive alternative respiration, and, besides integration with ubiquitous eukaryotic compartments, their functioning must be coupled with plastid functioning. Moreover, given the sessile lifestyle of plants, their relative lack of protective barriers and present threats of climate change, the plant cell is an attractive model to understand the mechanisms of stress/organelle/cell integration in the context of environmental stress responses.ScopeThe involvement of mitochondria in this integration entails a complex network of signalling, which has not been fully elucidated, because of the great diversity of mitochondrial constituents (metabolites, reactive molecular species and structural and regulatory biomolecules) that are linked to stress signalling pathways. The present review analyses the complexity of stress signalling connexions that are related to the mitochondrial electron transport chain and oxidative phosphorylation system, and how they can be involved in stress perception and transduction, signal amplification or cell stress response modulation.ConclusionsPlant mitochondria are endowed with a diversity of multi-directional hubs of stress signalling that lead to regulatory loops and regulatory rheostats, whose functioning can amplify and diversify some signals or, conversely, dampen and reduce other signals. Involvement in a wide range of abiotic and biotic responses also implies that mitochondrial stress signalling could result in synergistic or conflicting outcomes during acclimation to multiple and complex stresses, such as those arising from climate change.
Current challenges and best-practice protocols for microbiome analysis
Authors: Bharti Richa , Grimm Dominik G 
Published: November 2019

AbstractAnalyzing the microbiome of diverse species and environments using next-generation sequencing techniques has significantly enhanced our understanding on metabolic, physiological and ecological roles of environmental microorganisms. However, the analysis of the microbiome is affected by experimental conditions (e.g. sequencing errors and genomic repeats) and computationally intensive and cumbersome downstream analysis (e.g. quality control, assembly, binning and statistical analyses). Moreover, the introduction of new sequencing technologies and protocols led to a flood of new methodologies, which also have an immediate effect on the results of the analyses. The aim of this work is to review the most important workflows for 16S rRNA sequencing and shotgun and long-read metagenomics, as well as to provide best-practice protocols on experimental design, sample processing, sequencing, assembly, binning, annotation and visualization. To simplify and standardize the computational analysis, we provide a set of best-practice workflows for 16S rRNA and metagenomic sequencing data (available at https://github.com/grimmlab/MicrobiomeBestPracticeReview).
Multivessel percutaneous coronary intervention with bifurcation stenting in a quadfurcated single coronary artery from the right aortic sinus: a case report
Authors: Al Jarallah Mohammed , Rajan Rajesh , Kotevski Vladimir , Dashti Raja , Moustafa Wagdy 
Published: November 2019

Abstract

Background
Quadfurcation of single coronary artery (SCA) from the right is an extremely rare anomaly and acute coronary syndrome in such patients is catastrophic.

Case summary
We report a 56-year-old Bangladeshi male who presented with an acute inferior wall ST-elevation myocardial infarction. He was taken to the Cath lab for primary percutaneous coronary intervention which showed the presence of SCA arising from the right aortic sinus with multiple lesions including a bifurcation lesion. Percutaneous coronary intervention was done successfully in two sessions.

Discussion
Tackling multiple lesions in a case of SCA with quadfurcation was challenging especially in the setting of SCA and bifurcation lesions. This is first reported case of this kind.
The Rhododendron Genome and Chromosomal Organization Provide Insight into Shared Whole-Genome Duplications across the Heath Family (Ericaceae)
Authors: Soza Valerie L , Lindsley Dale , Waalkes Adam , Ramage Elizabeth , Patwardhan Rupali P , Burton Joshua N , Adey Andrew , Kumar Akash , Qiu Ruolan , Shendure Jay , Hall Benjamin 
Published: November 2019

Abstract
The genus Rhododendron (Ericaceae), which includes horticulturally important plants such as azaleas, is a highly diverse and widely distributed genus of &gt;1,000 species. Here, we report the chromosome-scale de novo assembly and genome annotation of Rhododendron williamsianum as a basis for continued study of this large genus. We created multiple short fragment genomic libraries, which were assembled using ALLPATHS-LG. This was followed by contiguity preserving transposase sequencing (CPT-seq) and fragScaff scaffolding of a large fragment library, which improved the assembly by decreasing the number of scaffolds and increasing scaffold length. Chromosome-scale scaffolding was performed by proximity-guided assembly (LACHESIS) using chromatin conformation capture (Hi-C) data. Chromosome-scale scaffolding was further refined and linkage groups defined by restriction-site associated DNA (RAD) sequencing of the parents and progeny of a genetic cross. The resulting linkage map confirmed the LACHESIS clustering and ordering of scaffolds onto chromosomes and rectified large-scale inversions. Assessments of the R. williamsianum genome assembly and gene annotation estimate them to be 89% and 79% complete, respectively. Predicted coding sequences from genome annotation were used in syntenic analyses and for generating age distributions of synonymous substitutions/site between paralgous gene pairs, which identified whole-genome duplications (WGDs) in R. williamsianum. We then analyzed other publicly available Ericaceae genomes for shared WGDs. Based on our spatial and temporal analyses of paralogous gene pairs, we find evidence for two shared, ancient WGDs in Rhododendron and Vaccinium (cranberry/blueberry) members that predate the Ericaceae family and, in one case, the Ericales order.
Serotonin regulates maternal calcium homeostasis during the perinatal period of sheep
Authors: Jin Lu , Nameiriga  , Sun Haizhou , Dan Sang , Li Shengli , Zhang Chongzhi , Zhang Chunhua , Ren Xiaoping , Shan Dan , Ling Shuli 
Published: November 2019

Abstract
The goal of this experiment was to demonstrate the ability of an infusion of serotonin (5-HT; 5-hydroxytryptamine) precursors to increase 5-HT production during the transition from pregnancy to lactation and its effects on gene expression related to calcium (Ca) transporters in the mammary gland and bone resorption markers in the femur. Thirty pregnant Bamei mutton sheep were randomly assigned to 3 experimental groups. All groups received a daily intravenous infusion of saline (control group; n = 10), saline containing 0.178 mg of L-tryptophan/kg body weight (BW) (TRP group, n = 10) or 0.178 mg of 5-hydroxytryptophan/kg BW (5-HTP group, n = 10), beginning on day 7 of prepartum and continuing until delivery. Serum (pre- and postpartum), milk (postpartum), and femur and mammary gland tissue (day 9) were collected. Sheep infused with 5-HTP had a larger total serum Ca concentration on days 3, 6, 15, and 30 of lactation and total milk Ca concentration on days 3, 6, 12, and 15 of lactation compared with that of the control group. Sheep infused with 5-HTP and TRP increased blood and milk concentrations of 5-HT on days 3, 6, 9, and 30 of lactation and parathyroid hormone-related protein (PTHrP) on day 3 of prepartum and on days 3, 6, and 15 of lactation (P &lt; 0.05). In addition, compared to that of the control group, the TRP or 5-HTP infusion upregulated PTHrP, a sodium/calcium exchanger, plasma membrane Ca2+ ATPase 2, secretory pathway Ca2+ ATPase 1, and calcium sensing receptor mRNA expression in mammary gland and receptor-activated nuclear factor kappa-B ligand mRNA expression in the femur, but had no effect on receptor-activated nuclear factor kappa-B and osteoprotegerin mRNA expression in the femur (P &lt; 0.05). This suggests that 5-HT and PTHrP may be involved in regulating maternal Ca homeostasis during the transition from pregnancy to lactation in the sheep.
Peri-operative pain management in hip arthroscopy: a systematic review of the literature
Authors: Kolaczko Jensen G , Knapik Derrick M , Salata Michael J 
Published: November 2019

AbstractThe purpose of this article was to review current literature on peri-operative pain management in hip arthroscopy. A systematic review of the literature on pain control in hip arthroscopy published January 2008 to December 2018 was performed. Inclusion criteria consisted of English language or articles with English translations, subjects undergoing hip arthroscopy with documented peri-operative pain control protocols in studies reporting Level I to IV evidence. Exclusion criteria were non-English articles, animal studies, prior systematic review or meta-analyses, studies not reporting peri-operative pain control protocols, studies documenting only pediatric (&lt;18 years of age) patients, studies with Level V evidence and studies including less than five subjects. Statistical analysis was performed to assess pain protocols on narcotic consumption in PACU, VAS score on discharge, time to discharge from PACU and incidence of complications. Seventeen studies were included, comprising 1674 patients. Nerve blocks were administered in 50% of patients (n = 838 of 1674), of which 88% (n = 740 of 838) received a pre-operative block while 12% (n = 98 of 838) post-operative block. Sixty-eight complications were recorded: falls (54%, n = 37), peripheral neuritis (41%, n = 28), seizure (1.5%, n = 1), oxygen desaturation and nausea (1.5%, n = 1) and epidural spread resulting in urinary retention (1.5%, n = 1). No significant differences in narcotic consumption, VAS score at discharge, time until discharge or incidence of complication was found based on pain control modality utilized. No statistically significant difference in PACU narcotic utilization, VAS pain scores at discharge, time to discharge or incidence of complications was found between peri-operative pain regimens in hip arthroscopy.
Unbiased Estimation of Linkage Disequilibrium from Unphased Data
Authors: Ragsdale Aaron P , Gravel Simon 
Published: November 2019

AbstractLinkage disequilibrium (LD) is used to infer evolutionary history, to identify genomic regions under selection, and to dissect the relationship between genotype and phenotype. In each case, we require accurate estimates of LD statistics from sequencing data. Unphased data present a challenge because multilocus haplotypes cannot be inferred exactly. Widely used estimators for the common statistics r2 and D2 exhibit large and variable upward biases that complicate interpretation and comparison across cohorts. Here, we show how to find unbiased estimators for a wide range of two-locus statistics, including D2, for both single and multiple randomly mating populations. These unbiased statistics are particularly well suited to estimate effective population sizes from unlinked loci in small populations. We develop a simple inference pipeline and use it to refine estimates of recent effective population sizes of the threatened Channel Island Fox populations.
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53
Authors: Capdevielle Caroline , Desplat Angélique , Charpentier Justine , Sagliocco Francis , Thiebaud Pierre , Thézé Nadine , Fédou Sandrine , Hooks Katarzyna B , Silvestri Romano , Guyonnet-Duperat Veronique , Petrel Melina , Raymond Anne-Aurélie , Dupuy Jean-William , Grosset Christophe F , Hagedorn Martin 
Published: November 2019

Abstract

Background
Diffuse midline glioma (DMG) is a pediatric malignancy with poor prognosis. Most children die less than one year after diagnosis. Recently, mutations in histone H3 have been identified and are believed to be oncogenic drivers. Targeting this epigenetic abnormality using histone deacetylase (HDAC) inhibitors such as panobinostat (PS) is therefore a novel therapeutic option currently evaluated in clinical trials.

Methods
BH3 profiling revealed engagement in an irreversible apoptotic process of glioma cells exposed to PS confirmed by annexin-V/propidium iodide staining. Using proteomic analysis of 3 DMG cell lines, we identified 2 proteins deregulated after PS treatment. We investigated biological effects of their downregulation by silencing RNA but also combinatory effects with PS treatment in vitro and in vivo using a chick embryo DMG model. Electron microscopy was used to validate protein localization.

Results
Scaffolding proteins EBP50 and IRSp53 were upregulated by PS treatment. Reduction of these proteins in DMG cell lines leads to blockade of proliferation and migration, invasion, and an increase of apoptosis. EBP50 was found to be expressed in cytoplasm and nucleus in DMG cells, confirming known oncogenic locations of the protein. Treatment of glioma cells with PS together with genetic or chemical inhibition of EBP50 leads to more effective reduction of cell growth in vitro and in vivo.

Conclusion
Our data reveal a specific relation between HDAC inhibitors and scaffolding protein deregulation which might have a potential for therapeutic intervention for cancer treatment.
Extensive brainstem infiltration, not mass effect, is a common feature of end-stage cerebral glioblastomas
Authors: Drumm Michael R , Dixit Karan S , Grimm Sean , Kumthekar Priya , Lukas Rimas V , Raizer Jeffrey J , Stupp Roger , Chheda Milan G , Kam Kwok-Ling , McCord Matthew , Sachdev Sean , Kruser Timothy , Steffens Alicia , Javier Rodrigo , McCortney Kathleen , Horbinski Craig 
Published: November 2019

Abstract

Background
Progress in extending the survival of glioblastoma (GBM) patients has been slow. A better understanding of why patient survival remains poor is critical to developing new strategies. Postmortem studies on GBM can shed light on why patients are dying.

Methods
The brains of 33 GBM patients were autopsied and examined for gross and microscopic abnormalities. Clinical-pathologic correlations were accomplished through detailed chart reviews. Data were compared with older published autopsy GBM studies that predated newer treatment strategies, such as more extensive surgical resection and adjuvant temozolomide.

Results
In older GBM autopsy series, mass effect was observed in 72% of brains, with herniation in 50% of all cases. Infiltration of tumor into the brainstem was noted in only 21% of those older cases. In the current series, only 10 of 33 (30%) GBMs showed mass effect (P = 0.0003), and only 1 (3%) showed herniation (P &lt; 0.0001). However, extensive GBM infiltration of the brainstem was present in 22 cases (67%, P &lt; 0.0001), with accompanying destruction of the pons and white matter tracts. There was a direct correlation between longer median patient survival and the presence of brainstem infiltration (16.1 mo in brainstem-invaded cases vs 9.0 mo in cases lacking extensive brainstem involvement; P = 0.0003).

Conclusions
With improving care, severe mass effect appears to be less common in GBM patients today, whereas dissemination, including life-threatening brainstem invasion, is now more pronounced. This has major implications regarding preclinical GBM models, as well as the design of clinical trials aimed at further improving patient survival.
Aberrant reward prediction error during Pavlovian appetitive learning in alexithymia
Authors: Starita Francesca , Pietrelli Mattia , Bertini Caterina , di Pellegrino Giuseppe 
Published: November 2019

AbstractExtensive literature shows that alexithymia, a subclinical trait defined by difficulties in identifying and describing feelings, is characterized by multifaceted impairments in processing emotional stimuli. Nevertheless, its underlying mechanisms remain elusive. Here, we hypothesize that alexithymia may be characterized by an alteration in learning the emotional value of encountered stimuli and test this by assessing differences between individuals with low (LA) and high (HA) levels of alexithymia in the computation of reward prediction errors (RPEs) during Pavlovian appetitive conditioning. As a marker of RPE, the amplitude of the feedback-related negativity (FRN) event-related potential was assessed while participants were presented with two conditioned stimuli (CS) associated with expected or unexpected feedback, indicating delivery of reward or no-reward. No-reward (vs reward) feedback elicited the FRN both in LA and HA. However, unexpected (vs expected) feedback enhanced the FRN in LA but not in HA, indicating impaired computation of RPE in HA. Thus, although HA show preserved sensitivity to rewards, they cannot use this response to update the value of CS that predict them. This impairment may hinder the construction of internal representations of emotional stimuli, leaving individuals with alexithymia unable to effectively recognize, respond and regulate their response to emotional stimuli.
Methplotlib: analysis of modified nucleotides from nanopore sequencing
Authors: De Coster Wouter , Strazisar Mojca 
Published: November 2019

AbstractSummaryModified nucleotides play a crucial role in gene expression regulation. Here we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies sequencing platforms, together with additional scripts for statistical analysis of allele specific modification within subjects and differential modification frequency across subjects.Availability and implementationThe methplotlib command-line tool is written in Python3, is compatible with Linux, Mac OS and the MS Windows 10 Subsystem for Linux and released under the MIT license. The source code can be found at https://github.com/wdecoster/methplotlib and can be installed from PyPI and bioconda. Our repository includes test data and the tool is continuously tested at travis-ci.com.Contactwouter.decoster@uantwerpen.vib.be