bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate
Authors: Wu Yueh-Fu O. , Bryant Annamarie T. , Nelson Nora T. , Madey Alexander G. , Fernandes Gail F. , Goodson Holly V. 
Published: January 2021

AbstractProper regulation of microtubule (MT) dynamics is critical for cellular processes including cell division and intracellular transport. Plus-end tracking proteins (+TIPs) dynamically track growing MTs and play a key role in MT regulation. +TIPs participate in a complex web of intra- and inter-molecular interactions known as the +TIP network. Hypotheses addressing the purpose of +TIP:+TIP interactions include relieving +TIP autoinhibition and localizing MT regulators to growing MT ends. In addition, we have proposed that the web of +TIP:+TIP interactions has a physical purpose, creating a superstructure that constrains the structural fluctuations of the fragile MT tip and thus acts as a polymerization chaperone. Many animal +TIP network proteins are multivalent and have intrinsically disordered regions, features commonly found in biomolecular condensates. This observation suggests that the +TIP network might under some conditions form a biomolecular condensate. Previous studies have shown that overexpression of the +TIP CLIP-170 induces large “patch” structures containing CLIP-170 and other +TIPs. To test the hypothesis that these patches might be biomolecular condensates, we used video microscopy, immunofluorescence staining, and Fluorescence Recovery After Photobleaching (FRAP). Our data show that the CLIP-170-induced patches have hallmarks indicative of a biomolecular condensate, one that contains +TIP proteins and excludes other known condensate markers. Moreover, bioinformatic studies demonstrate that the presence of intrinsically disordered regions is conserved in key +TIPs, implying that these regions are functionally significant. Together, these results indicate that the CLIP-170 induced patches in cells are phase-separated liquid condensates and raise the possibility that the endogenous +TIP network might form a liquid droplet at MT ends or other +TIP locations.
The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival
Authors: Paul Rupam , Banerjee Sourav , Sen Samarpita , Dubey Pratiksha , Maji Saptarshi , Bachhawat Anand K , Datta Rupak , Gupta Arnab 
Published: January 2021

AbstractCopper is essential for all life forms; however in excess it is extremely toxic. Toxic properties of copper are utilized by hosts against various pathogenic invasions.Leishmania, in its both free-living and intracellular forms, was found to exhibit appreciable tolerance towards copper-stress. To determine the mechanism of copper-stress evasion employed byLeishmaniawe identified and characterized the hitherto unknown Copper-ATPase inLeishmania majorand determined its role in parasite’s survival in host macrophage cells.L. majorCu-ATPase, LmATP7, exhibits high homology with its orthologues at multiple conserved motifs. In promastigotes, LmATP7 localized to the plasma membrane with a fraction in intracellular puncta. Upon copper treatment,LmATP7expression increases few folds. LmATP7 is capable of complementing copper transport in Cu-ATPase-Δ yeast strain. Promastigotes overexpressingLmATP7exhibits higher survival upon copper stress indicating efficacious copper export compared to wild type and heterozygousLmATP7knock-out parasites. We explored macrophage-Leishmanialinteraction with respect to copper stress subjected by the host upon parasite and the parasite’s reciprocating response thereon to evade the stress. The Copper-P-type-ATPases ATP7A/7B serve as major copper exporters in mammals that maintain cellular copper levels. We found thatLeishmaniainfection triggers ATP7A upregulation in macrophages. Additionally, as part of host response, ATP7A traffics from trans-Golgi network and transports copper to the endosomal and endolysosomal compartments harbouring theLeishmaniaamastigotes. Finally, we showLmATP7overexpression in this parasite increased amastigote survivability within infected macrophages whereas knocking it down reduces that drastically, establishing its role in combating host-induced copper stress.
Social interaction and effectiveness of the online learning – A moderating role of maintaining social distance during the pandemic COVID-19
Authors: Baber Hasnan 
Published: January 2021

PurposeThe pandemic of COVID-19 has pushed most of the classroom learning to an online environment with which most of the people were not familiar. This study aims to investigate the importance of social interaction on the effectiveness of online learning during the pandemic when social distancing norms are in place.Design/methodology/approachThis study uses the partial least square (PLS) structural equation modeling (SEM) approach, a nonparametric method based on total variance, using the SmartPLS software 3.0. The data were collected using the snowball sampling technique from the students who were learning online due to the pandemic COVID-19 and asked them to forward the survey link in their network.FindingsThe results suggested that social interaction has a positive significant impact on the effectiveness of online learning. However, this effect is reduced in the presence of social distance norms as people give more importance to continuous learning and to saving lives rather than socializing in the online environment.Originality/valueThe study will be helpful for instructors and educational institutes to formalize the strategies to enhance social interaction in online learning and analyze their pedagogy to improve effectiveness.
Effect of financial technology on cash holding in Nigeria
Authors: Onah Emmanuel Onyebuchi , Ujunwa Angela Ifeanyi , Ujunwa Augustine , Ogundele Oloruntoba Samuel 
Published: January 2021

PurposeThis paper aims to examine the effect of financial technology on cash holding in Nigeria.Design/methodology/approachThe authors use Pesaran et al.’s (2001) autoregressive distributed lag (ARDL) bounds test approach to cointegration to estimate the long-run relationship between four direct measures of financial technology (automated teller machine [ATM], Internet banking [IB], point of sale [POS] and mobile banking [MB]) and cash holding.FindingsThe authors find the presence of long-run negative relationship between cash holding and the four direct measures of financial technology.Practical implicationsDespite the negative effect of financial technology on cash holding, the descriptive results highlight increasing trajectory in cash holding. This suggests that structural factors such as ethical climate, literacy level, household characteristics, currency denomination structures, economic uncertainty and infrastructure deficit may account for the pervasive cash transactions in Nigeria and not necessarily the unwillingness of economic agents to use digital platform for financial transactions.Originality/valueThis study contributes to existing literature by augmenting the money demand function to accommodate direct measures of financial technology in examining the effectiveness of the policy on cash holding in Nigeria.
Empirical study of consumer participation motivation in value cocreation within cultural and creative virtual brand communities
Authors: Chen Longshan , Yuan Leping , Zhu Zhangxiang 
Published: January 2021

PurposeThis paper aims to examine the motivation for consumer participation in value cocreation and its impact on value cocreation behavior within cultural and creative virtual brand communities.Design/methodology/approachThrough an in-depth analysis of the psychological needs of the users of short videos, the motivations for user participation in value cocreation are categorized based on the self-determination theory, and six theoretical models are proposed for the impacts of participation motivation on the different levels of value cocreation behavior. Our research hypotheses are validated by conducting a regression analysis based on the 277 valid responses collected.FindingsRanked from highest to lowest by the degree of impact, the motivational factors that have significant positive impacts on browsing behavior are altruistic motivation, information motivation, social motivation, and hedonic motivation. The motivational factors that have significant positive impacts on member interaction behavior are achievement motivation, hedonic motivation, social motivation, and brand identity, while the motivational factors that have significant positive impacts on content creation behavior are achievement motivation, altruistic motivation, information motivation, and social motivation.Originality/valueThis current paper enriches the research on the consumer’s value cocreation behavior in virtual brand communities and provides constructive relevant platform manager’s suggestions for increasing user participation.
The J-shaped curve-conceptual and methodological challenges
Authors: Grønbæk Morten , Ellison R. Curtis , Skovenborg Erik 
Published: January 2021

Purpose
The purpose of this paper is to review the conceptual and methodological challenges of a J-shaped association between alcohol consumption (AC), coronary heart disease (CHD) and all-cause mortality. In associated papers in this journal, Skovenborg et al., 2021 reviews the evidence for the J-shaped curve, and Ellison et al., 2021 examines the advantages and drawbacks of Mendelian randomization studies of the J-shaped curve.

Design/methodology/approach
A number of methodological problems are common in observational research in general, and some of the methodological problems suggested for the J-shaped alcohol-CHD-associations are discussed. The extent of the methodological problems in studies of the J-shaped curve is reviewed, and the possibility that the J-shaped curve is an artifact created by reverse causality and residual confounding is discussed. Further, the issue of interaction with drinking pattern and type of alcohol is discussed.

Findings
Imprecise categorization of alcohol intake information seems to have had little effect on the J-shaped alcohol-CHD-associations, nor has it affected the ability of these studies to show increasing mortality from a range of causes with increasing AC. The problem of “sick quitters” has been resolved by large studies using lifelong abstainers or infrequent drinkers as reference group. Many studies lack information on drinking patterns with regard to regular, moderate consumption versus binge drinking. Stratified analyses by important risk factors for CHD have not significantly changed the J-shaped association observed in most epidemiologic studies.

Originality/value
Potential biases and residual confounding probably do not overcome the J-shaped alcohol-CDH-association observed in most epidemiologic studies; however, the existence of a J-shaped curve is challenged by some degree of uncertainty. The actual review together with the associated papers by Skovenborg et al., 2021 and Ellison et al., 2021 offers a possibility to “update your priors” and achieve greater certainty when giving your patients information on the pros and cons of alcohol intake.
CEOs as agents of change and continuity
Authors: Kelan Elisabeth K. , Wratil Patricia 
Published: January 2021

PurposeChief executive officers (CEOs) are increasingly seen as change agents for gender equality, which means that CEOs have to lead others to achieve gender equality. Much of this leadership is going to happen through talk, which raises the question as to how CEOs talk about gender equality to act as change agents. The purpose of this paper is to understand the arguments of CEOs deploy.Design/methodology/approachDrawing on interviews with global CEOs, who have publicly supported gender equality work, the article draws on discourse analysis to understand the arguments of CEOs deploy.FindingsThe analysis shows that CEOs deploy three arguments. First, CEOs argue that women bring special skills to the workplace, which contributes to a female advantage. Second, CEOs argue that the best person for the job is hired. Third, CEOs talk about how biases and privilege permeate the workplace. The analysis shows that CEOs are often invested in essentialised views of gender while holding onto ideals of meritocracy.Originality/valueThe article suggests that how leaders talk about gender equality leads to continuity, rather than change in regard to gender equality.
The influence of green HRM practices on green service behaviors: the mediating effect of green knowledge sharing
Authors: Rubel Mohammad Rabiul Basher , Kee Daisy Mui Hung , Rimi Nadia Newaz 
Published: January 2021

PurposeThe purpose of this study intends to examine the influence of green human resource management (GHRM) on green service behaviors through the mediating effect of green knowledge sharing based on bank employees' perceptions.Design/methodology/approachThe study analyzes 365 frontline employees' perceptions from the banking industry in Bangladesh using partial least square.FindingsThe findings show a significant positive direct influence of GHRM on green in-role, extra-role service behavior and green knowledge sharing. Green knowledge sharing is also found to have a significant mediating effect between GHRM and green service behaviors.Research limitations/implicationsThis study considers perceptions of employees of the private commercial banking organizations, and thereby, its findings cannot be generalized for all other service organizations in the context of Bangladesh.Practical implicationsThe study demonstrates that GHRM can influence employees' green service behaviors via green knowledge sharing.Originality/valueGreen banking is an emerging trend that deserves more attention. There is growing recognition that green banking is not an “automatic” process but requires that banking management promote green service behavior among their employees. This study extends the research on GHRM by focusing on how it impacts green service behavior through the mediating role of green knowledge sharing. The paper provides practical insights for organizations looking to improve green service behaviors among employees.
To continue or not to continue: a structural analysis of antecedents of mobile payment systems in India
Authors: Raman Prashant , Aashish Kumar 
Published: January 2021

PurposeConsumers in India are increasingly using mobile payment systems (MPSs) to make online and offline payments. Digital payment applications are gradually being used as surrogates for cash, checks and plastic money. The motive behind this research is to analyze the different antecedents that impact the users' willingness to continue using the MPS in India.Design/methodology/approachAn extensive study of the literature review supports the creation of a framework that describes the continuance intention of using MPS. Data from a survey of 612 respondents from India were collected to assess the research model. The study used partial least squares (PLS)–structural equation modeling (SEM) technique to empirically validate the framework developed.FindingsThe outcomes of the research suggest that service quality, attitude, effort expectancy and perceived risk act as influencing antecedents of continuance intention to use MPS. Determinants like perceived trust, convenience and social value have no influence on users' continuance intention. SEM analysis has verified the proposed model, which explains 50.7% of the variance of the users' continuance intention of using MPSs.Research limitations/implicationsThe research is built upon cross-sectional data carried out in India. Hence, the outcomes of the study are limited to this region only.Practical implicationsEngaging with the consumers for a long time and enabling their continuance usage are extremely important for firms offering mobile payment services. The managerial implications provide insights into the different ways to capture new business opportunities to the firms rendering mobile payment services in the wake of changing consumer behavior.Originality/valueThis research tries to analyze users' continuance intention to use MPS in India. Although many research studies have investigated the willingness of the individuals to adopt novel technology in different frameworks, there are hardly any empirical studies carried out to analyze the antecedents of users' continuance intention to use MPSs.
Corporate social responsibility for women's empowerment: a study on Nigerian banks
Authors: Mogaji Emmanuel , Hinson Robert Ebo , Nwoba Arinze Christian , Nguyen Nguyen Phong 
Published: January 2021

PurposeDrawing on stakeholder theory, the purpose of this paper examines how Nigerian banks employ their corporate social responsibility (CSR) initiatives to empower women to participate in economic and commercial activities.Design/methodology/approachThe methodology of this paper is regarding a thematic analysis of Nigerian banks' annual CSR and sustainability reports.FindingsA theoretical framework was developed which illustrates the investment foundation (Sustainable Development Goals, Women's Empowerment Principles (WEPs) and Nigerian Sustainable Banking Principles) that supports the different levels of engagement (healthcare, financial, social and career empowerment) aimed at different groups of women (women at large, women in business and women in career) in the society.Research limitations/implicationsThe study findings are confined to the banks in Nigeria, focussing on how they empower women to participate in economic and commercial activities.Practical implicationsIt is paramount that Nigerian banks consistently report their CSR initiatives. When designing these initiatives, it is equally important to incorporate WEPs, as they are specifically focussed on women.Social implicationsDue to their low-level institutional and financial development, it is important that Nigerian banks design their CSR initiatives to improve women empowerment. While initiatives should be targeted at women's well-being and physical health, it is important to steer women towards financial and social independence through loans, grants and mentorship.Originality/valueTo the best of the authors' knowledge, no other research study has examined how banks in an emerging market use their CSR activities to empower women to participate in financial activities.
Developing movement experiences with refugees to the United States who have undergone trauma
Authors: Dieterich-Hartwell Rebekka , Haen Craig , Kaimal Girija , Koch Sabine , Villanueva Augusta , Goodill Sherry 
Published: January 2021

Purpose
The purpose of this study is to investigate what resources recent refugees to the USA tap into and how collaborative expressive movements were experienced with regard to coping and resourcing, and to derive a theoretical model that would inform the use of dance/movement therapy and other holistic treatment modalities with refugees.

Design/methodology/approach
A total of 13 refugees overall participated in parts of this study. Ten of these refugees completed movement sessions and semi-structured in-person interviews. Constructivist grounded theory methods and descriptive statistics were used to analyze the data.

Findings
The findings suggest that refugees draw on a number of resources. The collaborative movement experiences seemed to have both a settling and mobilizing effect with the most important phenomenon of connection to the self or to another person. A grounded theory model, developed based on the findings, shows a dynamic interaction between the encountered categories.

Research limitations/implications
The findings are preliminary and not transferrable because of limited size and potential researcher bias.

Practical implications
The findings contribute to an understanding of the resettlement and acculturation phase of refugees with potential implications and suggestions for current clinical practices and health services.

Originality/value
This study was original in its focus on understanding the role and the potential of body and expressive movement among refugees who have experienced trauma. Adherence to transformative paradigm principles invited participants to become co-researchers.
The logic and integration of coproductive research approaches
Authors: Lindhult Erik , Axelsson Karin 
Published: January 2021

PurposeThe purpose of this paper is to clarify the methodological logic of coproductive research approaches like action research, collaborative research, interactive research and participatory research in a way that can clarify its effectiveness and scientific qualities in high quality knowledge production, and show the way that it can be integrated with institutionalized textbook science.Design/methodology/approachThe paper clarifies the character of coproduction as research methodology concept, the logic of coproductive research approaches, and its characteristics compared to quantitative and qualitative methodology. A model for characterizing research approaches from leading textbook social science is developed to specify the character of coproductive research approaches and support integration in mainstream research methodology discussions.FindingsThe paper develops a research methodology framework for coproductive logic and approaches to research, to support the integration of this type of approaches in mainstream research methodology.Research limitations/implicationsThe developed model of coproductive research approaches is not empirically described. Therefore, researchers are encouraged to test and further develop the model in relation to cases and designs of research projects.Practical implicationsThe paper is helpful for guiding the design of coproductive research in practice, i.e., in research project development or in research methodology education.Social implicationsThe development of coproductive research approaches supports making science relevant and useful for solving pressing problems and improving social conditions. It also is enabling stakeholders to participate in research and development processes, thus the democratization of research and knowledge production.Originality/valueThe paper contributes to integration of the family of coproductive approaches in mainstream research methodology discussion through the development and elaboration of a framework for organizing the description and development of coproductive research approaches. The aim is that the framework is valuable for both academics, practitioners and students in designing coproductive research projects.