bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and Characterizing Tropical Oceanic Mesoscale Cold Pools using Spaceborne Scatterometer Winds
Authors: Garg Piyush , Nesbitt Stephen W. , Lang Timothy J. , Priftis George , Chronis Themis , Thayer Jeffrey D. , Hence Deanna A. 
Published: February 2020

AbstractConvective cold pools over oceans contribute to the air‐sea exchange of heat and moisture. Beyond cold pools' physical properties, cold pools and their intersections are important mechanisms controlling the life cycle of tropical convective systems. However, few observational techniques are available to routinely observe the properties of cold pools and their association with convection. The primary goal of this study is to demonstrate a new technique using gradients in remotely sensed ocean vector winds as a proxy for the structure and characteristics of tropical oceanic cold pools. Using Advanced Scatterometer (ASCAT) vector wind retrievals with field of view of 12.5 km, regions of enhanced gradients in surface winds are identified as gradient features. A 3‐km Weather Research and Forecasting (WRF) model simulation was carried out to illustrate the technique over the Indian Ocean during the 2011 DYNAmics of Madden‐Julian Oscillation (DYNAMO) field campaign. A forward operator was applied to the model wind fields, allowing direct comparisons of wind gradients and virtual temperature‐defined cold pool thermodynamic and kinematic properties. In situ buoy measurements of air temperature were also used to validate ASCAT‐identified cold pools. Quantitative skill metrics demonstrate that the technique has a low false alarm rate (<10%), high critical success index (>85%), and a low bias (~1). The gradient feature technique was then applied to ASCAT‐retrieved ocean vector winds, revealing global variations in cold pool properties. These properties are shown to be related to the properties of global convective systems observed by the Tropical Rainfall Measurement Mission (TRMM).
The Spectral Nature of Stratospheric Temperature Adjustment and its Application to Halocarbon Radiative Forcing
Authors: Shine K. P. , Myhre G. 
Published: February 2020

AbstractStratospheric temperature adjustment (STA) is often a significant component of greenhouse gas radiative forcing (RF), for both the most widely used definition of RF and effective radiative forcing. It is well established that the magnitude and sign of STA differs among greenhouse gases, being negative (at the tropopause) for CO2 increases (because it induces a cooling of the stratosphere) and positive for many halocarbons (because they induce a warming of the stratosphere); this effect is strongly related to the opacity (and hence the effective emitting temperature) of the troposphere at the wavelengths at which gases absorb. Here the spectral variation of STA is examined for the first time by systematically imposing a weak absorber in each of 300 bands of a narrow‐band radiation code. For this weak absorber, STA is negative for wavelengths greater than about 13 μm and positive in the 8‐ to 13‐μm “window” except in the vicinity of the 9.6‐μm ozone band. By combining narrow‐band and line‐by‐line model results, these findings are used to improve a widely used fast method to estimate radiative efficiency (RE, the RF per unit change in concentration) directly from laboratory measurements or theoretical calculations of halocarbon absorption cross sections; the new method reproduces detailed RE calculations to better than 1.4%. This is a significant improvement over a cruder method used to account for STA in RE tabulations in the Intergovernmental Panel on Climate Change's Fifth Assessment Report, which were used to calculate metrics such as the Global Warming Potential, for halocarbons and related substances.
Interannual Variability of the Outflow of Weddell Sea Bottom Water
Authors: Gordon Arnold L. , Huber Bruce A. , Abrahamsen E. Povl 
Published: February 2020

AbstractThe Weddell Sea Bottom Water (WSBW) export from 1999 to 2019 displays distinct seasonal and interannual variability. From 2014 into 2017 a marked salinity decrease was recorded, with the lowest salinity, 34.615, attained in early 2016. The reduced salinity is derived from the V‐shaped trough formed by a double front along the shelf break of the Weddell Gyre's western boundary, which is filled with a blend of surface water and modified Weddell Deep Water. We estimate that when the V‐shaped apex attains a depth of greater than ~700 m, the thermobaric effect promotes its descent into the WSBW. We propose that this occurred during anomalously strong cyclonic wind stress curl over the Weddell Gyre from 2014 into 2017, which increased the intensity of the gyre and its western boundary current, deepening the V‐shape trough. The WSBW salinity increased to its prior to 2014 values as the wind stress relaxed in 2018.
Chrononutrition in the management of diabetes
Authors: Henry Christiani Jeyakumar , Kaur Bhupinder , Quek Rina Yu Chin 
Published: February 2020

AbstractCircadian rhythms are 24-h cycles regulated by endogeneous molecular oscillators called the circadian clock. The effects of diet on circadian rhythmicity clearly involves a relationship between factors such as meal timings and nutrients, known as chrononutrition. Chrononutrition is influenced by an individual’s “chronotype”, whereby “evening chronotypes” or also termed “later chronotype” who are biologically driven to consume foods later in the day. Research in this area has suggested that time of day is indicative of having an influence on the postprandial glucose response to a meal, therefore having a major effect on type 2 diabetes. Cross-sectional and experimental studies have shown the benefits of consuming meals early in the day than in the evening on postprandial glycaemia. Modifying the macronutrient composition of night meals, by increasing protein and fat content, has shown to be a simple strategy to improve postprandial glycaemia. Low glycaemic index (GI) foods eaten in the morning improves glycaemic response to a greater effect than when consumed at night. Timing of fat and protein (including amino acids) co-ingested with carbohydrate foods, such as bread and rice, can reduce glycaemic response. The order of food presentation also has considerable potential in reducing postprandial blood glucose (consuming vegetables first, followed by meat and then lastly rice). These practical recommendations could be considered as strategies to improve glycaemic control, rather than focusing on the nutritional value of a meal alone, to optimize dietary patterns of diabetics. It is necessary to further elucidate this fascinating area of research to understand the circadian system and its implications on nutrition that may ultimately reduce the burden of type 2 diabetes.
DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder
Authors: Bonvicini Cristian , Cortese Samuele , Maj Carlo , Baune Bernhard T. , Faraone Stephen V. , Scassellati Catia 
Published: February 2020

AbstractThe identification of biomarkers to support the diagnosis and prediction of treatment response for attention-deficit/hyperactivity disorder (ADHD) is still a challenge. Our previous works highlighted the DRD4 (dopamine receptor D4) as the best potential genetic marker for childhood diagnosis and methylphenidate (MPH) response. Here, we aimed to provide additional evidence on biomarkers for ADHD diagnosis and treatment response, by using more specific approaches such as meta-analytic and bioinformatics tools. Via meta-analytic approaches including over 3000 cases and 16,000 controls, we demonstrated that, among the different variants studied in DRD4 gene, the 48-base pair, Variable Tandem Repeat Polymorphism, VNTR in exon 3 showed an age/population-specificity and an allelic heterogeneity. In particular, the 7R/“long” allele was identified as an ADHD risk factor in European-Caucasian populations (d = 1.31, 95%CI: 1.17–1.47, Z = 4.70/d = 1.36, 95%CI: 1.20–1.55, Z = 4.78, respectively), also, from the results of last meta-analysis, linked to the poor MPH efficacy. The 4R/“short” allele was a protective factor in European-Caucasian and South American populations (d = 0.83, 95%CI: 0.75–0.92, Z = 3.58), and was also associated to positive MPH response. These results refer to children with ADHD. No evidence of such associations was detected for adults with persistent ADHD (data from the last meta-analysis). Moreover, we found evidence that the 4R allele leads to higher receptor expression and increased sensitivity to dopamine, as compared with the 7R allele (d = 1.20, 95%CI: 0.71–1.69, Z = 4.81), and this is consistent with the ADHD protection/susceptibility effects of the respective alleles. Using bioinformatics tools, based on the latest genome-wide association (GWAS) meta-analysis of the Psychiatry Genomic Consortium (PGC), we demonstrated that the 48 bp VNTR is not in Linkage Disequilibrium with the DRD4 SNPs (Single Nucleotide Polymorphisms), which were not found to be associated with ADHD. Moreover, a DRD4 expression downregulation was found in ADHD specific brain regions (Putamen, Z score = −3.02, P = 0.00252). Overall, our results suggest that DRD4 48 bp VNTR variants should be considered as biomarkers to support the diagnosis of ADHD and to predict MPH response, although the accuracy of such a biomarker remains to be further elucidated.
Unstable crop yields reveal opportunities for site-specific adaptations to climate variability
Authors: Martinez-Feria Rafael A. , Basso Bruno 
Published: February 2020

AbstractWater deficit and water excess constitute severe stresses that limit crop yield and are likely to intensify as climate becomes more variable. Regional crop production aggregates for the US Midwest indicate widespread yield losses in past decades due to both extreme rainfall and water limited conditions, though the degree to which these weather impacts are related to site-specific factors such as landscape position and soils has not been examined in a systematic manner. This study offers observational evidence from a large sample of commercial crop fields to support the hypothesis that landscape position is the primary mediator of crop yield responses to weather within unstable field zones (i.e., zones where yields tend to fluctuate between high and low, depending on the year). Results indicate that yield losses in unstable zones driven by water excess and deficits occur throughout a wide range of seasonal rainfall, even simultaneously under normal weather. Field areas prone to water stress are shown to lag as much as 23–33% below the field average during drought years and 26–33% during deluge years. By combining large-scale spatial datasets, we identify 2.65 million hectares of water-stress prone cropland, and estimate an aggregated economic loss impact of $536M USD yr−1, 4.0 million tons yr−1 of less CO2 fixed in crop biomass, and 52.6 Gg yr−1 of more reactive N in the environment. Yield stability maps can be used to spatially implement adaptation practices to mitigate weather-induced stresses in the most vulnerable cropland.
Short-term and long-term effects of a social network intervention on friendships among university students
Authors: Boda Zsófia , Elmer Timon , Vörös András , Stadtfeld Christoph 
Published: February 2020

AbstractInformal social relations, such as friendships, are crucial for the well-being and success of students at all levels of education. Network interventions can aim at providing contact opportunities in school settings to prevent the social isolation of individuals and facilitate integration between otherwise segregated social groups. We investigate the short-term and long-term effects of one specific network intervention in an undergraduate cohort freshly admitted to an engineering department ($${\bf{N}}{\boldsymbol{=}}{\bf{226}}$$
N
=
226
). In this intervention, we randomly assigned students into small groups at an introduction event two months prior to their first day at university. The groups were designed to increase mixed-gender contact opportunities. Two months after the intervention, we find a higher rate of friendships, common friends, and mixed-gender friendships in pairs of students who were assigned to the same group than in pairs from different groups (short-term effects). These effects gradually diminish over the first academic year (long-term effects). Using stochastic actor-oriented models, we investigate the long-term trajectory of the intervention effects, while considering alternative network processes, such as reciprocity, transitivity, homophily, and popularity. The results suggest that even though the induced friendship ties are less stable than other friendships, they may serve as early seeds for complex social network processes. Our study shows that simple network interventions can have a pronounced short-term effect and indirect long-term effects on the evolution and structure of student communities.
Transdiagnostic Phenotyping Reveals a Host of Metacognitive Deficits Implicated in Compulsivity
Authors: Seow Tricia X. F. , Gillan Claire M. 
Published: February 2020

AbstractRecent work suggests that obsessive-compulsive disorder (OCD) patients have a breakdown in the relationship between explicit beliefs (i.e. confidence about states) and updates to behaviour. The precise computations underlying this disconnection are unclear because case-control and transdiagnostic studies yield conflicting results. Here, a large online population sample (N = 437) completed a predictive inference task previously studied in the context of OCD. We tested if confidence, and its relationship to action and environmental evidence, were specifically associated with self-reported OCD symptoms or common to an array of psychiatric phenomena. We then investigated if a transdiagnostic approach would reveal a stronger and more specific match between metacognitive deficits and clinical phenotypes. Consistent with prior case-control work, we found that decreases in action-confidence coupling were associated with OCD symptoms, but also 5/8 of the other clinical phenotypes tested (8/8 with no correction applied). This non-specific pattern was explained by a single transdiagnostic symptom dimension characterized by compulsivity that was linked to inflated confidence and several deficits in utilizing evidence to update confidence. These data highlight the importance of metacognitive deficits for our understanding of compulsivity and underscore how transdiagnostic methods may prove a more powerful alternative over studies examining single disorders.
Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function
Authors: González-Blázquez Raquel , Alcalá Martín , Fernández-Alfonso María S. , Villa-Valverde Palmira , Viana Marta , Gil-Ortega Marta , Somoza Beatriz 
Published: February 2020

AbstractThe experimental approach for the study of cardiometabolic disorders requires the use of animal models fed with commercial diets whose composition differs notably, even between diets used for control groups. While chow diets are usually made of agricultural by-products, purified low-fat diets (LF) contain a higher percentage of easy metabolizable carbohydrates, together with a reduced amount of polyunsaturated fatty acids, micronutrients and fiber, all associated with metabolic and vascular dysfunction. We hypothesize that the LF diet, commonly used in control animals, could promote adverse vascular and metabolic outcomes. To address this issue, 5-week-old male C57BL6J mice were fed with a standard (Chow) or a LF diet for 6 weeks. Changes in body weight, adiposity, biochemical parameters, systemic and aortic insulin sensitivity and endothelial function were recorded. LF diet did not modify body weight but significantly impaired systemic glucose tolerance and increased triglycerides and cholesterol levels. Endothelial function and aortic insulin sensitivity were significantly impaired in the LF group, due to a reduction of NO availability. These findings highlight the importance of selecting the proper control diet in metabolic studies. It may also suggest that some cardiometabolic alterations obtained in experimental studies using LF as a control diet may be underestimated.
Brushed lubricant-impregnated surfaces (BLIS) for long-lasting high condensation heat transfer
Authors: Seo Donghyun , Shim Jaehwan , Lee Choongyeop , Nam Youngsuk 
Published: February 2020

AbstractRecently, lubricant-impregnated surfaces (LIS) have emerged as a promising condenser surface by facilitating the removal of condensates from the surface. However, LIS has the critical limitation in that lubricant oil is depleted along with the removal of condensates. Such oil depletion is significantly aggravated under high condensation heat transfer. Here we propose a brushed LIS (BLIS) that can allow the application of LIS under high condensation heat transfer indefinitely by overcoming the previous oil depletion limit. In BLIS, a brush replenishes the depleted oil via physical contact with the rotational tube, while oil is continuously supplied to the brush by capillarity. In addition, BLIS helps enhance heat transfer performance with additional route to droplet removal by brush sweeping. By applying BLIS, we maintain the stable dropwise condensation mode for > 48 hours under high supersaturation levels along with up to 61% heat transfer enhancement compared to hydrophobic surfaces.
Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups
Authors: Askeland Cecilie , Wik Elisabeth , Finne Kenneth , Birkeland Even , Arnes Jarle B. , Collett Karin , Knutsvik Gøril , Krüger Kristi , Davidsen Benedicte , Aas Turid , Eide Geir Egil , Stefansson Ingunn M. , Foulkes William D. , Akslen Lars A. 
Published: February 2020

AbstractStudies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, vascular and immune responses, BRCA1 germline status, basal-like differentiation, clinico-pathologic features, and survival. Immunohistochemical staining was performed on breast cancers from two series (cohort 1, n = 187; cohort 2, n = 198), and mass spectrometry data from 24 cases and 12 breast cancer cell lines was examined for proteomic profiles. Open databases were also explored (TCGA, METABRIC, Oslo2 Landscape cohort, Cancer Cell Line Encyclopedia). High stathmin expression associated with tumour proliferation, p53 status, basal-like differentiation, BRCA1 genotype, and high-grade histology. These patterns were confirmed using mRNA data. Stathmin mRNA further associated with tumour angiogenesis, immune responses and reduced survival. By logistic regression, stathmin protein independently predicted a BRCA1 genotype (OR 10.0, p = 0.015) among ER negative tumours. Cell line analysis (Connectivity Map) implied PI3K inhibition in tumours with high stathmin. Altogether, our findings indicate that stathmin might be involved in the regulation of tumour angiogenesis and immune responses in breast cancer, in addition to tumour proliferation. Cell data point to potential effects of PI3K inhibition in tumours with high stathmin expression.
Sucrose promotes caries progression by disrupting the microecological balance in oral biofilms: an in vitro study
Authors: Du Qian , Fu Min , Zhou Yuan , Cao Yangpei , Guo Tingwei , Zhou Zhou , Li Mingyun , Peng Xian , Zheng Xin , Li Yan , Xu Xin , He Jinzhi , Zhou Xuedong 
Published: February 2020

AbstractSucrose has long been regarded as the most cariogenic carbohydrate. However, why sucrose causes severer dental caries than other sugars is largely unknown. Considering that caries is a polymicrobial infection resulting from dysbiosis of oral biofilms, we hypothesized that sucrose can introduce a microbiota imbalance favoring caries to a greater degree than other sugars. To test this hypothesis, an in vitro saliva-derived multispecies biofilm model was established, and by comparing caries lesions on enamel blocks cocultured with biofilms treated with sucrose, glucose and lactose, we confirmed that this model can reproduce the in vivo finding that sucrose has the strongest cariogenic potential. In parallel, compared to a control treatment, sucrose treatment led to significant changes within the microbial structure and assembly of oral microflora, while no significant difference was detected between the lactose/glucose treatment group and the control. Specifically, sucrose supplementation disrupted the homeostasis between acid-producing and alkali-producing bacteria. Consistent with microbial dysbiosis, we observed the most significant disequilibrium between acid and alkali metabolism in sucrose-treated biofilms. Taken together, our data indicate that the cariogenicity of sugars is closely related to their ability to regulate the oral microecology. These findings advance our understanding of caries etiology from an ecological perspective.
Dynamic vs static behaviour of a supported nanoparticle with reaction-induced catalytic sites in a lattice model
Authors: Korobov Alexander 
Published: February 2020

AbstractModern literature shows a rapidly growing interest to the supported nanocatalysts with dynamic behaviour under reaction conditions. This new frontier of heterogeneous catalysis is recognized as one of the most challenging and worthy of consideration from all possible angles. In this context, a previously suggested lattice model is used to get an insight, by means of kinetic Monte Carlo, into the influence of the mobility of reaction-induced catalytic sites of a two-dimensional supported nanoparticle on the system behaviour. The results speak in favour of feasibility of dynamic nanocatalysts with self-organized structures capable of robust functioning. This approach, from the macroscopic end, is believed to be a useful complement to ever developing experimental and first principle approaches.
Golden Gate assembly with a bi-directional promoter (GBid): A simple, scalable method for phage display Fab library creation
Authors: Chockalingam Karuppiah , Peng Zeyu , Vuong Christine N. , Berghman Luc R. , Chen Zhilei 
Published: February 2020

AbstractFabs offer an attractive platform for monoclonal antibody discovery/engineering, but library construction can be cumbersome. We report a simple method – Golden Gate assembly with a bi-directional promoter (GBid) – for constructing phage display Fab libraries. In GBid, the constant domains of the Fabs are located in the backbone of the phagemid vector and the library insert comprises only the variable regions of the antibodies and a central bi-directional promoter. This vector design reduces the process of Fab library construction to “scFv-like” simplicity and the double promoter ensures robust expression of both constituent chains. To maximize the library size, the 3 fragments comprising the insert – two variable chains and one bi-directional promoter – are assembled via a 3-fragment overlap extension PCR and the insert is incorporated into the vector via a high-efficiency one-fragment, one-pot Golden Gate assembly. The reaction setup requires minimal preparatory work and enzyme quantities, making GBid highly scalable. Using GBid, we constructed a chimeric chicken-human Fab phage display library comprising 1010 variants targeting the multi-transmembrane protein human CD20 (hCD20). Selection/counter-selection on transfected whole cells yielded hCD20-specific antibodies in four rounds of panning. The simplicity and scalability of GBid makes it a powerful tool for the discovery/engineering of Fabs and IgGs.