bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-Reported Outcome Measures in Cystic Fibrosis: Protocol for a Systematic Review
Authors: Ratnayake Irushi , Ahern Susannah , Ruseckaite Rasa 
Published: February 2020

Background
Patients with cystic fibrosis (CF) can struggle with burdensome symptoms and treatment regimens that negatively affect every aspect of their life. As physiological parameters can fail to capture these complications, the assessment of health-related quality of life (HRQOL) has gained prominence. HRQOL can be measured using standardized patient questionnaires called patient-reported outcome measures (PROMs). The Australian Cystic Fibrosis Data Registry (ACFDR) collects clinical data on adult and pediatric patients with CF. The incorporation of PROMs into the ACFDR would enable monitoring of HRQOL trends, benchmarking of HRQOL outcomes, and support of HRQOL research in CF.

Objective
Prior to incorporation of a PROM in the ACFDR, this systematic review was planned to evaluate whether any suitable PROMs are currently being used for CF.

Methods
This systematic review will be conducted in compliance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) guidelines. MEDLINE, EMBASE, Scopus, CINAHL (Cumulative Index of Nursing and Allied Health Literature), PsycINFO, and Cochrane Library databases were searched for articles published between January 2009 and February 2019 on the use of PROMs to measure HRQOL in adult and pediatric patients with CF. Study designs such as observational studies, reviews and validation studies were included. Studies describing randomized controlled trials, dissertations, books, guideline statements, and abstracts were excluded. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) risk of bias checklist was used to assess the methodological quality of included studies. A descriptive synthesis of the results will be undertaken in line with the outcomes of this study.

Results
As of July 2019, the search has been conducted and 4530 records were screened. After two phases of screening, 97 studies were included in the final review and subjected to data extraction. Reviewers are currently in the process of critical appraisal.

Conclusions
This review will identify any PROM(s) that may be used to measure HRQOL in the ACFDR.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42019126931; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=126931
Use of Smart Technology for the Early Diagnosis of Complications After Cardiac Surgery: The Box 2.0 Study Protocol
Authors: Biersteker Tom E , Boogers Mark J , de Lind van Wijngaarden Robert AF , Groenwold Rolf HH , Trines Serge A , van Alem Anouk P , Kirchhof Charles JHJ , van Hof Nicolette , Klautz Robert JM , Schalij Martin J , Treskes Roderick W 
Published: February 2020

Background
Atrial fibrillation (AF), sternal wound infection, and cardiac decompensation are complications that can occur after cardiac surgery. Early detection of these complications is clinically relevant, as early treatment is associated with better clinical outcomes. Remote monitoring with the use of a smartphone (mobile health [mHealth]) might improve the early detection of complications after cardiac surgery.

Objective
The primary aim of this study is to compare the detection rate of AF diagnosed with an mHealth solution to the detection rate of AF diagnosed with standard care. Secondary objectives include detection of sternal wound infection and cardiac decompensation, as well as assessment of quality of life, patient satisfaction, and cost-effectiveness.

Methods
The Box 2.0 is a study with a prospective intervention group and a historical control group for comparison. Patients undergoing cardiac surgery at Leiden University Medical Center are eligible for enrollment. In this study, 365 historical patients will be used as controls and 365 other participants will be asked to receive either The Box 2.0 intervention consisting of seven home measurement devices along with a video consultation 2 weeks after discharge or standard cardiac care for 3 months. Patient information will be analyzed according to the intention-to-treat principle. The Box 2.0 devices include a blood pressure monitor, thermometer, weight scale, step count watch, single-lead electrocardiogram (ECG) device, 12-lead ECG device, and pulse oximeter.

Results
The study started in November 2018. The primary outcome of this study is the detection rate of AF in both groups. Quality of life is measured with the five-level EuroQol five-dimension (EQ-5D-5L) questionnaire. Cost-effectiveness is calculated from a society perspective using prices from Dutch costing guidelines and quality of life data from the study. In the historical cohort, 93.9% (336/358) completed the EQ-5D-5L and patient satisfaction questionnaires 3 months after cardiac surgery.

Conclusions
The rationale and design of a study to investigate mHealth devices in postoperative cardiac surgery patients are presented. The first results are expected in September 2020.

Trial Registration
ClinicalTrials.gov NCT03690492; http://clinicaltrials.gov/show/NCT03690492

International Registered Report Identifier (IRRID)
DERR1-10.2196/16326
Effect of Methacryloyloxydecyl Dihydrogen Phosphate–Containing Silane and Adhesive Used Alone or in Combination on the Bond Strength and Chemical Interaction With Zirconia Ceramics Under Thermal Aging
Authors: Gutierrez MF , Perdigão J , Malaquias P , Cardenas AM , Siqueira F , Hass V , Reis A , Loguercio AD 
Published: February 2020

Clinical Relevance
Achieving durable bonding to zirconia is fundamental for the application of a methacryloyloxydecyl dihydrogen phosphate (MDP)–containing silane solution or an MDP-containing silane solution associated with an MDP-containing universal adhesive.

SUMMARY
Objectives: To evaluate the effect of a methacryloyloxydecyl dihydrogen phosphate (MDP)–containing silane coupling agent and universal adhesive, used alone or in combination, on the microshear bond strength (μSBS) to zirconia after 24 hours of water storage (24h) and after 10,000 thermocycles (TC), complemented with chemical analysis of the surface to establish the presence of MDP on the surface of the zirconia after bonding procedures.
Methods and Materials: Thirty computer-aided design/computed-aided manufacturing blocks of zirconia were cut into four sections (6×6×6 mm) and sintered. Zirconia sections (n=96) were assigned to 24 groups according to three factors: 1) silane (no silane, Monobond S [MBS], Monobond P [MB+]), 2) adhesive + resin cement (no adhesive + Enforce [ENF], no adhesive + RelyX Ultimate [REX], Prime&Bond Elect + Enforce [PBE/ENF], Scotchbond Universal + RelyX Ultimate [SBU/REX]), and 3) thermocycling (no thermocycling [24h], 10,000 thermocycles [TC]). Upon silane/adhesive application, cylinder-shaped matrices were filled with resin cement and light cured. Specimens were tested in μSBS (1.0 mm/min) after 24h or TC. The μSBS data were analyzed using twoway ANOVA and Tukey’s post hoc test (α=0.05). In addition, micro-Raman spectroscopy was used to analyze the zirconia surface for immediate chemical interaction analysis (n=24).
Results: For the 24h condition, PBE/ENF resulted in lower mean μSBS than both groups with silane without PBE (MBS and MB+ groups; p&lt;0.001). SBU alone or MB+ alone and MB+ associated with SBU showed the highest mean μSBS (p&lt;0.001). For the TC condition, all groups showed a significant decrease in mean μSBS compared with those of 24h (p&lt;0.001), with the exception of MB+ associated to SBU (p&gt;0.05). However, the application of MB+ alone or MB+ associated to SBU resulted in higher mean μSBS (p&lt;0.001) after TC than the remaining TC groups. In terms of chemical interaction, only the SBU groups, alone or combined with both of the silane agents, were associated with the methacrylate groups after rinsing.
Conclusions: The results of the current study support the use of an MDP-containing silane solution or an MDP-containing silane solution associated with an MDP-containing universal adhesive for bonding to air-abraded zirconia, as a more stable bonding after thermocycling.
Preventive Transcendental Of Mass Violence Crimes
Authors: Anggoro Purwadi Wahyu 
Published: February 2020

ABSTRACT Objectives: This article aims to explain the causes of criminal acts of violence that occur in cases of violence involving the masses and explicate the concept of preventing violent crimes involving masses who have a transcendental paradigm. Methodology: This research was qualitative nondoctrinal research. The strategy of applying Preventive Law with a Transcendental paradigm as a concept of preventing criminal acts of mass violence with religious nuances is as a way to reduce the emotions of the masses and eliminate the intention of the masses to commit acts of violence. The sources of data were in the form of research and interviews of cases of mass violence. The data analysis used interpretation techniques based on the (premise) stage of mass violence, according to Niel Smelser and transcendental preventive patterns in accordance with the literature reviews of books and scientific journals. Results: The results showed that violence is an act against the law (onrechtmatige daad), where it is the human state of nature. In the crowd, people will imitate other people's actions, lose control, and take aggressive actions. The law is a tool for social engineering to prevent crime, maintain an orderly society, and provide protection for citizens. Law enforcement is prioritized using soft methods (the soft hand of society) to prevent violence from happening with a transcendental paradigm approach to restoring human nature, according to Surah Ali Imran (3) paragraph 110, namely amar ma'ruf, which contains transcendental ethical values. Functions: This research is useful in the implementation of the Transcendental Preventive Law for law enforcement officers, in this case, the National Police, as an effort to break the 4th stage, namely the stage before triggering incidents occur. It is intended that at the time of mass violence, the Preventive Transcendental Law can cool down the emotions of the masses while at the same time restore human awareness that peace, compassion, and the world and its contents are a gift that must be accountable to God Almighty. Originality/Novelty: Transcendental Preventive Law is an effort to prevent violent crime in mass violence that is based on transcendental principles, by giving a religious touch to remind the masses that violence is a sinful act and to remind the existence of God Almighty.
Prediksi Intrusi Air Laut Berdasarkan Nilai Daya Hantar Listrik dan Total Dissolved Solid di Kabupaten Tangerang
Authors: Waspodo Roh Santoso Budi , Kusumarini Silvia , Dewi Vita Ayu Kusuma 
Published: February 2020

Intrusion of sea water is the infiltration of sea water into the soil. This might be caused by a groundwater excessive exploration. Tangerang District is one of the areas that have great potential sea water intrusion. The aim of research was to predict the limit of salt water intrusion based on the value of DHL and TDS. The primary data were measured using a TOA EC meter CM-14P and then were processed using Surfer 9.0 software and ArcGIS. The measurement results was compared with PAHIAA Decision (1986) and Carroll’s Classification (1962). The results showed that the intrusion area could be identified by DHL and TDS values. On the area located far from the beach, intrusion was influenced by the presence of a river in the region. This was indicated by the regression analysis that showed a correlation between distance and value DHL/TDS with a negative slope value. Based on DHL and TDS parameters in observation area, the groundwater conditions in Tangerang District within a radius of 0.095 km to 5 km from the littoral areas are categorized as medium intrusion zone (slightly brackish water) with DHL 1500-1999 μmhos/cm and TDS values 1000-3000 mg/LU.
KARAKTERISTIK BUAH MANGGIS, ALPUKAT, DAN JAMBU BIJI PADA PENYIMPANAN SUHU RENDAH
Authors: Sukmawaty Sukmawaty , Ahzani Muhammad , Putra Guyup Mahardhian Dwi 
Published: February 2020

Penelitian ini bertujuan untuk mengamati perubahan karakteristik bahan hasil pertanian yang disimpan pada penyimpanan suhu rendah. Penelitian ini dilakukan dengan metode eksperi mental dengan tiga perlakuan penyimpanan, yaitu penyimpanan cool box, penyimpanan dengan pengemas polietilen dan penyimpanan pada suhu ruang. Digunakan tiga macam buah sebagai obyek penelitian, yaitu buah manggis, alpukat, dan jambu biji. Parameter yang diamati pada penelitian ini yaitu kadar air, susut bobot, laju respirasi, indeks warna, dan nilai GMD. Penurunan nilai kekerasan ketiga jenis buah pada penyimpanan cool box lebih rendah dari penyimpanan pengemas polietylen dan penyimpanan suhu ruang. Terjadi perubahan warna buah selama penyimpanan dimana perubahan terendah pada penyimpanan cool box dan perubahan tertinggi pada penyimpanan suhu ruang untuk semua jenis buah. Kata kunci: manggis, alpukat, jambu biji, penyimpanan, suhu rendah
The political cartoonist and the editor
Authors: Manning Haydon , Phiddian Robert 
Published: February 2020

New Zealand Herald cartoonist Malcolm Evans was dismissed from the newspaper after he refused to follow his editor's instruction to cease cartooning on the Israeli-Palestinian conflict. Members of the Jewish community were upset by a number of his cartoons, drawn during the first half of 2003. Evans is not alone among cartoonists to attract the anger of Jewish community lobbies and the hesitation of their editors when presenting cartoons dealing with the activities of the Israeli government. Cartoonists Tony Auth (Philadelphia Inquirer) and Michael Leunig (The Age) have also presented controversial cartoon commenting on the Israeli Government and, with Evans, defend their work on the grounds that while cartoons may offend an audience the content is not necessarily wrong. Cartoonists fiercely defend their licence to mock politicians, governments and states. This article examines this defence and the space within which cartoonists examine political subjects. We analyse the parameters within which mass circulation newspaper editors operate, principally in the Australian context. We defend a wide licence for cartoonists and argue that this licence represents an important measure of free speech in an era when the threat of terrorism looms large on national political agendas.
REVIEW: Unchallenged bible of NZ media law
Authors: Samson Alan 
Published: February 2020

Review of Media Law in New Zealand (5th ed.), by John Burrows and Ursula Cheer and The Journalist's Guide to Media Law: Dealing with Legal and Ethical Issues (2d ed.), by Mark PearsonBurrows and Cheers have provided a greatly expanded analysis of the developing area of privacy law, an area watched with trepidation by the news media after several high profile court cases, both in New Zealand and overseas.
Pearson also deserves praises for his clear chapter on the freedom of the press, a fundamental concept that is too easiy glossed over in benevolent democracies.
EDITORIAL: A legacy of gendered culture
Authors: Bedggood Janet , Oosterman Allison 
Published: February 2020

This edition of Pacific Journalism Review has a gender theme. Sex is a fundamental division in all societies; all human behaviour has a biological base. The differences between men and women often involve inequalities, and this stratification is frequently seen as due to innate characteristics present in all societies. But what we do with our biological capacities is mainly a matter of learning. Anthropologists tell us that people learn their gender roles; knowing how to be a woman or a man in any society, is culturally learned. Historically, the diversity of traditional gender roles across the Pacific reveals many forms of gender difference. Women’s status varied in the region. The complexity of cultural behaviour and belief systems, the variability in the gender divisions of labour and sociopolitical systems show there were a range of determinants of female and male activities. Men and women were treated differently and behaved differently.
REVIEW: A revelation about human rights and the ‘war on terror’
Authors: Stephenson Jon 
Published: February 2020

Review of The Great War for Civilisation: The Conquest of the Middle East, by Robert Fisk
Since 9/11 and the US-led invasion of Afghanistan and Iraq, British journalist Robert Fisk has built a huge following as a staunch critic of George W. Bush’s ‘war on terror’. But Fisk’s cogent—often controversial—analysis of American foreign policy and Western meddling and mendacity in the Middle East is nothing new: based in Beirut, he has reported for 30 years on conflicts from Algeria to Afghanistan.
Acute immunologic and metabolic responses of beef heifers following topical administration of flunixin meglumine at various times relative to bovine herpesvirus 1 and Mannheimia haemolytica challenges
Authors: Word Alyssa B. , Broadway P. Rand , Burdick Sanchez Nicole C. , Hutcheson John P. , Ellis Guy B. , Holland Ben P. , Ballou Michael A. , Carroll Jeffery A. 
Published: February 2020

Abstract

OBJECTIVE
To quantify acute immunologic and metabolic responses of beef heifers following topical administration of transdermal flunixin meglumine (TDFM) at various times relative to bovine herpesvirus 1 (BHV1) and Mannheimia haemolytica challenges.

ANIMALS
32 beef heifers (mean body weight, 170 kg).

PROCEDURES
Heifers were assigned to 1 of 4 groups. Heifers in the control group did not receive TDFM, whereas 1 dose of TDFM (3.3 mg/kg) was topically applied to heifers of groups A, V, and B at −144, −72, and 0 hours. All heifers were inoculated with 1 × 108 plaque-forming units of BHV1 in each nostril at −72 hours and with 1.18 × 106 CFUs of M haemolytica intratracheally at 0 hours. Vaginal temperature was recorded and blood samples were collected for quantification of select immunologic and metabolic biomarkers at predetermined times from −144 to 360 hours.

RESULTS
Mean vaginal temperature was similar between group A and the control group. Mean vaginal temperatures for groups V and B were generally lower than that for the control group following BHV1 and M haemolytica challenges, respectively. Mean neutrophil oxidative burst capacity and L-selectin expression at 0 hours were significantly decreased for group V relative to the other groups. Other biomarkers did not differ among the groups at any time.

CONCLUSIONS AND CLINICAL RELEVANCE
Results suggested that topical administration of TDFM to beef cattle effectively alleviated pyrexia without adverse effects on acute immunologic or metabolic responses when TDFM was administered at the same time as, but not before, respiratory pathogen challenge.
On Robust Estimation of Error Variance in (Highly) Robust Regression
Authors: Kalina Jan , Tichavský Jan 
Published: February 2020

Abstract
The linear regression model requires robust estimation of parameters, if the measured data are contaminated by outlying measurements (outliers). While a number of robust estimators (i.e. resistant to outliers) have been proposed, this paper is focused on estimating the variance of the random regression errors. We particularly focus on the least weighted squares estimator, for which we review its properties and propose new weighting schemes together with corresponding estimates for the variance of disturbances. An illustrative example revealing the idea of the estimator to down-weight individual measurements is presented. Further, two numerical simulations presented here allow to compare various estimators. They verify the theoretical results for the least weighted squares to be meaningful. MM-estimators turn out to yield the best results in the simulations in terms of both accuracy and precision. The least weighted squares (with suitable weights) remain only slightly behind in terms of the mean square error and are able to outperform the much more popular least trimmed squares estimator, especially for smaller sample sizes.
Automatic Strain Gauge Balance Design Optimization Approach and Implementation Based on Integration of Software
Authors: Xiang Guangwei , Mi Peng , Yi Guoqing , Wang Chao , Liu Wei 
Published: February 2020

Abstract
The traditional wind tunnel strain balance design cycle is a manual iterative process. With the experience and intuition of the designer, one solution that meets the design requirements can be selected among a small number of design solutions. This paper introduces a novel software integration-based automatic balance design optimization system (ABDOS) and its implementation by integrating professional design knowledge and experience, stepwise optimization strategy, CAD-CAE software, self-developed scripts and tools. The proposed two-step optimization strategy includes the analytical design process (ADP) and the finite element method design process (FEDP). The built-in optimization algorithm drives the design variables change and searches for the optimal structure combination meeting the design objectives. The client-server based network architecture enables local lightweight design input, task management, and result output. The high-performance server combines all design resources to perform all the solution calculations. The development of more than 10 balances that have been completed and a case study show that this method and platform significantly reduce the time for design evaluation and design-analysis-redesign cycles, assisting designers to comprehensively evaluate and improve the performance of the balance.
Donner à voir : explorer et exploiter les images en histoire de ľinterprétation
Authors: Pelea Alina 
Published: February 2020

Abstract
It may be too much to say that a picture is worth a thousand words, but no one can deny the informative potential of visual representations. Considering that the history of translation would also benefit from their use, we propose an intervention that will try to look at these resources in order to shed additional light on the status of the interpreter and its evolution. We analyze visual resources dating back to the 17th and 18th centuries (works of art) and others from 2018 (potentially more objective) to see how they reflect, on the one hand, the status of the dragomans of the Sublime Porte and, on the other hand, that of today’s interpreters. In conducting this research, we also look at how new technologies can contribute to the study of different media.