bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing role of abstinence and infecundity in non-use of contraceptive methods in India
Authors: Dhillon Preeti , Singh Govind , Ram Faujdar , Kumar Pradeep , Saggurti Niranjan 
Published: March 2020

AbstractThis paper assesses the reasons for non-use of contraceptive methods, and the possible complexity of reported data on women in India. The study used recent data from two successive rounds of the National Family Health Survey (NFHS) (2005–06: N=37,296; 2015–16: N=247,024), which surveyed currently married women aged 15–49 years. The reporting on non-use of contraceptives and the changing pattern of the reasons for non-use were analysed, classified into fertility and other cited reasons. The self-reported reasons for non-use of contraception were verified with other related information captured in the survey. Bivariate and logistic regression analyses were conducted. Sexual abstinence (not having sex: 10%; infrequent sex: 3%) and infecundity (menopausal/hysterectomy: 12%; subfecund/infecund: 10%) were the most commonly reported reasons for non-use of contraceptive methods in 2015–16, followed by refusal to use (10%). The proportion of non-users who wanted to have a child soon (25% to 21%), were pregnant (16% to 13%), in postpartum amenorrhoea (68% to 40%) and who had method-related reasons (10% to 6%) declined over time (from 2005–06 to 2015–16, respectively). A higher proportion of less-educated women reported abstinence (6%) and menopause/hysterectomy (19%) than educated women. Abstinence was more commonly reported in states with low prevalence of modern contraceptive use. The findings suggest that the increasing trend of abstinence and infecundity among non-users of contraception may be a concern for future research and reproductive health programmes, as it questions both the quality of data and sexual health of married couples.
Do Firms Purposefully Change Capital Structure? Evidence from an Investment-Opportunity Shock to Drug Firms
Authors: Giambona Erasmo , Golec Joseph , Lopez-de-Silanes Florencio 
Published: March 2020

AbstractWe study the capital structure changes of drug firms after an investment-opportunity shock brought about by the Biologics Price Competition and Innovation Act. Using a difference-in-difference approach, we show that the shock led drug firms to make their capital structures less constraining by decreasing leverage, shortening debt maturity, increasing unsecured debt, and reducing convertible debt. New debt covenants became less restrictive and firms raised equity to preserve borrowing capacity. Our results support the view that firms actively manage their capital structures to bolster financial flexibility and increase debt capacity in response to new investment opportunities.
Predicting preferred prey of Sumatran tigersPanthera tigris sumatraevia spatio-temporal overlap
Authors: Allen Maximilian L. , Sibarani Marsya C. , Krofel Miha 
Published: March 2020

AbstractEncounter rates of carnivores with prey are dependent on spatial and temporal overlap, and are often highest with their preferred prey. The Critically Endangered Sumatran tigerPanthera tigris sumatraeis dependent on prey populations, but little is known about its prey preferences. We collected camera-trap data for 7 years (2010–2016) in Bukit Barisan Selatan National Park, Sumatra, to investigate spatial and temporal overlap of tigers with potential prey species. We also developed a novel method to predict predator–prey encounter rates and potential prey preferences from camera-trap data. We documented at least 10 individual tigers, with an overall detection rate of 0.24 detections/100 trap nights. Tigers exhibited a diurnal activity pattern and had highest temporal overlap with wild boarSus scrofaand pig-tailed macaquesMacaca nemestrina, but highest spatial overlap with wild boar and sambar deerRusa unicolor. We created a spatial and temporal composite score and three additional composite scores with adjustments for the spatial overlap and preferred prey mass. Wild boars ranked highest for all composite scores, followed by sambar deer, and both are known as preferred tiger prey in other areas. Spatial and temporal overlaps are often considered as separate indices, but a composite score may facilitate better predictions of encounter rates and potential prey preferences. Our findings suggest that prey management efforts in this area should focus on wild boar and sambar deer, to ensure a robust prey base for this Critically Endangered tiger population.
PERTURBATION THEOREMS FOR FRACTIONAL CRITICAL EQUATIONS ON BOUNDED DOMAINS
Authors: ALGHANEMI AZEB , CHTIOUI HICHEM 
Published: March 2020

AbstractWe consider the fractional critical problem$A_{s}u=K(x)u^{(n+2s)/(n-2s)},u>0$in$\unicode[STIX]{x1D6FA},u=0$on$\unicode[STIX]{x2202}\unicode[STIX]{x1D6FA}$, where$A_{s},s\in (0,1)$, is the fractional Laplace operator and$K$is a given function on a bounded domain$\unicode[STIX]{x1D6FA}$of$\mathbb{R}^{n},n\geq 2$. This is based on A. Bahri’s theory of critical points at infinity in Bahri [Critical Points at Infinity in Some Variational Problems, Pitman Research Notes in Mathematics Series, 182 (Longman Scientific & Technical, Harlow, 1989)]. We prove Bahri’s estimates in the fractional setting and we provide existence theorems for the problem when$K$is close to 1.
Upping my game as a parent: Attributed gains in participating in a cancer parenting program for child-rearing parents with advanced cancer
Authors: Zahlis Ellen H. , Shands Mary Ellen , Lewis Frances Marcus 
Published: March 2020

AbstractObjectivesThe objective of this study was to describe in the words of child-rearing parents with incurable cancer, what they had gained or thought about as a result of participating in a five-session, scripted, telephone-delivered psycho-educational parenting intervention, the Enhancing Connections Program in Palliative Care.MethodsA total of 26 parents completed the program. Parents’ responses were audio-recorded and transcribed verbatim and verified for accuracy. The analysis proceeded through four steps: unitizing, coding into categories, defining categories, and formation of a core construct that explained parents’ attributed gains. Trustworthiness of study results was protected by coding to consensus, formal peer debriefing, and maintaining an audit trail.ResultsAlthough 50% reached or exceeded clinical cutoff scores on anxiety and 42% reached or exceeded clinical cutoff scores on depressed mood, parents extensively elaborated what they gained. Results revealed six categories of competencies they attributed to their participation in the program: (1) being ready for a conversation about my cancer, (2) bringing things out in the open, (3) listening better to my child, (4) getting my child to open up, (5) not getting in my child's way, and (6) changing my parenting.ConclusionsDespite an extensive symptom burden, parents with incurable cancer attributed major gains from a brief, fully scripted, cancer parenting communication intervention. A manualized telephone-delivered educational counseling program for symptomatic parents with incurable cancer has the potential to augment competencies for parents as they assist their children manage the cancer experience.
Favorable Conditions for Magnetic Reconnection at Ganymede's Upstream Magnetopause
Authors: Kaweeyanun N. , Masters A. , Jia X. 
Published: March 2020

AbstractGanymede is the only Solar System moon known to generate a permanent magnetic field. Jovian plasma motions around Ganymede create an upstream magnetopause, where energy flows are thought to be driven by magnetic reconnection. Simulations indicate Ganymedean reconnection events may be transient, but the nature of magnetopause reconnection at Ganymede remains poorly understood, requiring an assessment of reconnection onset theory. We present an analytical model of steady‐state conditions at Ganymede's magnetopause, from which the first Ganymedean reconnection onset assessment is conducted. We find that reconnection may occur wherever Ganymede's closed magnetic field encounters Jupiter's ambient magnetic field, regardless of variations in magnetopause conditions. Unrestricted reconnection onset highlights possibilities for multiple X lines or widespread transient reconnection at Ganymede. The reconnection rate is controlled by the ambient Jovian field orientation and hence driven by Jupiter's rotation. Future progress on this topic is highly relevant for the JUpiter ICy moon Explorer mission.
Distribution in Saturn's Inner Magnetosphere From 2.4 to 10 RS: A Diffusive Equilibrium Model
Authors: Persoon A. M. , Kurth W. S. , Gurnett D. A. , Faden J. B. , Groene J. B. , Morooka M. W. , Wahlund J. E. , Wilson R. J. , Menietti J. D. 
Published: March 2020

AbstractElectron density measurements have been obtained by the Cassini Radio and Plasma Wave Science (RPWS) instrument covering the period from 30 June 2004 to 19 April 2017, spanning latitudes up to ~30° and L values from 2.4 to 10. Near the F ring, electron densities are derived from RPWS measurements of electron plasma oscillations at high latitudes and from the Langmuir Probe (RPWS/LP) sweep data at low latitudes. The electron density measurements from the ring‐grazing orbits, beginning in December 2016, have made it possible to extend the work of a previous diffusive equilibrium model to include the distribution of the ring plasma. Beyond the ring‐grazing orbits, the densities are derived from RPWS measurements of the upper hybrid resonance frequency. These density measurements are used to anchor the fit of an expanded diffusive equilibrium density model for a two‐species plasma consisting of water group and hydrogen ions in Saturn's inner magnetosphere. Density contour plots for the two ion species and the electrons are presented. The distribution of the derived plasma densities is consistent with two primary sources, the Enceladus plume and the extended ring atmosphere. There is also an indication of a weaker plasma source at Dione. In the region just outside the A ring and in the region including the Enceladus orbit, the diffusive equilibrium model also shows the expansion of lighter ions and electrons to higher latitudes along the magnetic field lines with evidence of a weaker plasma expansion between the orbits of Tethys and Dione.
Toward Distributed Fiber‐Optic Sensing of Subsurface Deformation: A Theoretical Quantification of Ground‐Borehole‐Cable Interaction
Authors: Zhang Cheng‐Cheng , Shi Bin , Zhu Hong‐Hu , Wang Bao‐Jun , Wei Guang‐Qing 
Published: March 2020

AbstractFiber‐optic sensing is emerging as a superior means for distributed strain sensing of the subsurface. The ability of an embedded fiber‐optic cable to capture accurate strain profiles depends on the degree of rigid mechanical coupling between the ground and the cable. However, a current challenge in this field is to determine the actual level of ground deformation from strain signatures sensed by the cable deployed in the subsurface; addressing this issue has been hampered by the lack of suitable theoretical methods. Here we propose a two‐step ground‐cable coupling evaluation procedure, whereby we develop analytical formulations to quantify the interaction and interface shear transfer of a ground‐borehole‐cable system. We constrain key model parameters using a data set acquired with a fiber optics‐instrumented borehole for monitoring groundwater‐related sediment compaction. Extensive parametric analyses reveal that increasing the backfill modulus and cable gauge length or decreasing the borehole radius and cable stiffness can improve the quality of strain transferred to the cable from the ground; the effect of ground properties is comparably insignificant. Further, we develop design charts and tables at designated transfer thresholds to facilitate the development and field deployment of fiber sensing elements. Taken together, the theoretical quantification of ground‐cable coupling should improve the state‐of‐the‐art performance of distributed fiber‐optic strain sensing for subsurface ground movements detection and monitoring.
Heat Wave Variations Across China Tied to Global SST Modes
Authors: Wei Jia , Wang Weiguang , Shao Quanxi , Yu Zhongbo , Chen Zefeng , Huang Yin , Xing Wanqiu 
Published: March 2020

AbstractProgressive intensification and proliferation of heat waves impose extensively impacts on entire environment and ecology. The far‐reaching implications of heat waves and the severe future projections emphasize the imperative need to explore the driving factors and their quantitative contribution to heat wave variations. In this study, a multiaspect characteristic of heat waves across China during 1961–2017 is evaluated using excess heat factor. Results showed that the number of events, frequency, duration, and intensity has heterogeneous spatial patterns, with a consistent abrupt transition in 1996–1997. The robust positive correlations between heat wave characteristics and warming sea surface temperature (SST) indicate the association of heat wave with SST anomalies. Except the number of events, the other factors (including the frequency, duration, and intensity) of heat waves are strongly influenced by El Niño‐Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD). However, the influences have significant variations from region to region, with the central regions experiencing significant decreases in the frequency, duration, and intensity of heat waves during the simultaneous ENSO phases (El Niño‐La Niña), in comparison with northern and western regions dominated by IOD (positive‐negative) experiencing longer and more frequent heat waves. Particularly, the mild heat waves are more vulnerable to the warming SST modes than severe heat waves. The decrease of heat waves is affected by the convergent winds bringing cold air from the high latitude, while the extensively significant increase of heat waves is controlled by the anomalously sinking motions.
Therapeutics targeting the fibrinolytic system
Authors: Lin Haili , Xu Luning , Yu Shujuan , Hong Wanjin , Huang Mingdong , Xu Peng 
Published: March 2020

AbstractThe function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia
Authors: Lei Yinrui , Chen Tao , Li Yeyi , Shang Man , Zhang Yan , Jin Yuepeng , Yu Qiujing , Guo Fang , Wang Ting 
Published: March 2020

AbstractThe protein O-GlcNAcylation catalysed by O-GlcNAc transferase (OGT) is tightly regulated by glucose availability. It is upregulated and essential for tumor cell proliferation under hypoxic conditions. However, the mechanism behind is still unclear. Here, we showed that the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), which also promotes cell cycle progression in the nucleus, was O-GlcNAcylated in response to hypoxia. The O-GlcNAcylation of PFKFB3 could compete phosphorylation by hypoxia-activated ERK at the same modification site Ser172. Phosphorylated PFKFB3 could interact with the protein G3BP2 and retain in the cytosol; this in turn led to the accumulation of hypoxia-induced-P27 in the nucleus resulting in the cell cycle arrest. Such a pathway was compromised by high level of PFKFB3 O-GlcNAcylation in tumor cells contributing to cell cycle progression. Consistently, the PFKFB3-Ser172 phosphorylation level inversely correlated with the OGT level in pancreatic cancer patients. Our findings uncovered an O-GlcNAcylation mediated mechanism to promote tumor cell proliferation under metabolic stress, linking the aberrant OGT activity to tumorigenesis in pancreatic cancer.
TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation
Authors: Niture Suryakant , Gyamfi Maxwell A. , Lin Minghui , Chimeh Uchechukwu , Dong Xialan , Zheng Weifan , Moore John , Kumar Deepak 
Published: March 2020

AbstractTumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with development of hepatocellular carcinoma (HCC). Increased TNFAIP8 levels in HCC cells enhanced cell survival by blocking apoptosis, rendering HCC cells more resistant to the anticancer drugs, sorafenib and regorafenib. TNFAIP8 also induced autophagy and steatosis in liver cancer cells. Consistent with these observations, TNFAIP8 blocked AKT/mTOR signaling and showed direct interaction with ATG3-ATG7 proteins. TNFAIP8 also exhibited binding with fatty acids and modulated expression of lipid/fatty-acid metabolizing enzymes. Chronic feeding of mice with alcohol increased hepatic levels of TNFAIP8, autophagy, and steatosis but not in high-fat-fed obese mice. Similarly, higher TNFAIP8 expression was associated with steatotic livers of human patients with a history of alcohol use but not in steatotic patients with no history of alcohol use. Our data indicate a novel role of TNFAIP8 in modulation of drug resistance, autophagy, and hepatic steatosis, all key early events in HCC progression.
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Authors: Fielden John , Wiseman Katherine , Torrecilla Ignacio , Li Shudong , Hume Samuel , Chiang Shih-Chieh , Ruggiano Annamaria , Narayan Singh Abhay , Freire Raimundo , Hassanieh Sylvana , Domingo Enric , Vendrell Iolanda , Fischer Roman , Kessler Benedikt M. , Maughan Timothy S. , El-Khamisy Sherif F. , Ramadan Kristijan 
Published: March 2020

AbstractEukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate—a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)—is stabilised. TOP1ccs are highly cytotoxic and a failure to resolve them underlies the pathology of neurological disorders but is also exploited in cancer therapy where TOP1ccs are the target of widely used frontline anti-cancer drugs. A critical enzyme for TOP1cc resolution is the tyrosyl-DNA phosphodiesterase (TDP1), which hydrolyses the bond that links a tyrosine in the active site of TOP1 to a 3’ phosphate group on a single-stranded (ss)DNA break. However, TDP1 can only process small peptide fragments from ssDNA ends, raising the question of how the ~90 kDa TOP1 protein is processed upstream of TDP1. Here we find that TEX264 fulfils this role by forming a complex with the p97 ATPase and the SPRTN metalloprotease. We show that TEX264 recognises both unmodified and SUMO1-modifed TOP1 and initiates TOP1cc repair by recruiting p97 and SPRTN. TEX264 localises to the nuclear periphery, associates with DNA replication forks, and counteracts TOP1ccs during DNA replication. Altogether, our study elucidates the existence of a specialised repair complex required for upstream proteolysis of TOP1ccs and their subsequent resolution.
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
Authors: Dietachmayr Michael , Rathakrishnan Abirami , Karpiuk Oleksandra , von Zweydorf Felix , Engleitner Thomas , Fernández-Sáiz Vanesa , Schenk Petra , Ueffing Marius , Rad Roland , Eilers Martin , Gloeckner Christian Johannes , Clemm von Hohenberg Katharina , Bassermann Florian 
Published: March 2020

AbstractRegulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In yeast, the dual phosphatase Cdc14 controls mitotic progression by antagonizing Cdk1-mediated protein phosphorylation. By contrast, specific mitotic functions of the mammalian Cdc14 orthologue CDC14B have remained largely elusive. Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms’ tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. We further demonstrate that WT1 functions as a mitotic transcription factor and specify CXCL8/IL-8 as a target gene of WT1 that conveys mitotic survival. Together, we describe a ubiquitin-dependent signaling pathway that directs a mitosis-specific transcription program to regulate mitotic survival.
Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
Authors: Mutoh Tomoyuki , Shirai Tsuyoshi , Ishii Tomonori , Shirota Yuko , Fujishima Fumiyoshi , Takahashi Fumiaki , Kakuta Yoichi , Kanazawa Yoshitake , Masamune Atsushi , Saiki Yoshikatsu , Harigae Hideo , Fujii Hiroshi 
Published: March 2020

AbstractThe presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system. A cDNA library of endothelial cells is retrovirally transfected into a rat myeloma cell line from which AECA-positive clones are sorted with flow cytometry. Four distinct AECA-positive clones are isolated, and endothelial protein C receptor (EPCR) and scavenger receptor class B type 1 (SR-BI) are identified as endothelial autoantigens. Autoantibodies against EPCR and SR-BI are detected in 34.6% and 36.5% of cases, respectively, with minimal overlap (3.8%). Autoantibodies against EPCR are also detected in ulcerative colitis, the frequent comorbidity of TAK. In mechanistic studies, EPCR and SR-BI function as negative regulators of endothelial activation. EPCR has also an effect on human T cells and impair Th17 differentiation. Autoantibodies against EPCR and SR-BI block the functions of their targets, thereby promoting pro-inflammatory phenotype.
Provincial and gridded population projection for China under shared socioeconomic pathways from 2010 to 2100
Authors: Chen Yidan , Guo Fang , Wang Jiachen , Cai Wenjia , Wang Can , Wang Kaicun 
Published: March 2020

AbstractIn response to a growing demand for subnational and spatially explicit data on China’s future population, this study estimates China’s provincial population from 2010 to 2100 by age (0–100+), sex (male and female) and educational levels (illiterate, primary school, junior-high school, senior-high school, college, bachelor’s, and master’s and above) under different shared socioeconomic pathways (SSPs). The provincial projection takes into account fertility promoting policies and population ceiling restrictions of megacities that have been implemented in China in recent years to reduce systematic biases in current studies. The predicted provincial population is allocated to spatially explicit population grids for each year at 30 arc-seconds resolution based on representative concentration pathway (RCP) urban grids and historical population grids. The provincial projection data were validated using population data in 2017 from China’s Provincial Statistical Yearbook, and the accuracy of the population grids in 2015 was evaluated. These data have numerous potential uses and can serve as inputs in climate policy research with requirements for precise administrative or spatial population data in China.