bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Tablet-Based, Engagement, Assessment, Support, and Sign-Posting (EASSi) Tool for Facilitating and Structuring Sexual Well-Being Conversations in Routine Prostate Cancer Care: Mixed-Methods Study
Authors: McCaughan Eilís , Flannagan Carrie , Parahoo Kader , Connaghan John , Maguire Roma , Steele Mary , Thompson Samantha , Jain Suneil , Kirby Michael , Brady Nuala , O'Connor Seán R 
Published: October 2020

Background
Long-term side-effects associated with different prostate cancer treatment approaches are common. Sexual challenges are the most frequently occurring issues and can result in increased psychological morbidity. It is recognized that barriers to communication can make initiating discussions around sexual concerns in routine practice difficult. Health care professionals need to routinely initiate conversations, effectively engage with patients, and assess needs in order to provide essential support. One proposed method that could support health care professionals to do this involves the use of prompts or structured frameworks to guide conversations.

Objective
This study aimed to assess feasibility, acceptability, and satisfaction with the tablet-based Engagement, Assessment, Support, and Sign-posting (EASSi) tool designed to facilitate and structure sexual well-being discussions in routine prostate cancer care.

Methods
Health care professionals (n=8) used the EASSi tool during 89 posttreatment appointments. Quantitative data were recorded based on program usage and surveys completed by health care professionals and patients. Qualitative data exploring perceptions on use of the tool were gathered using semistructured interviews with all health care professionals (n=8) and a sample of patients (n=10).

Results
Surveys were completed by health care professionals immediately following each appointment (n=89, 100%). Postal surveys were returned by 59 patients (66%). Health care professionals and patients reported that the tool helped facilitate discussions (81/89, 91% and 50/59, 85%, respectively) and that information provided was relevant (82/89, 92% and 50/59, 85%, respectively). The mean conversation duration was 6.01 minutes (SD 2.91). Qualitative synthesis identified the tool’s ability to initiate and structure discussions, improve the “depth” of conversations, and normalize sexual concerns.

Conclusions
The EASSi tool was appropriate and acceptable for use in practice and provided a flexible approach to facilitate routine brief conversations and deliver essential sexual well-being support. Further work will be conducted to evaluate the effectiveness of using the tablet-based tool in prostate cancer care settings.
COVID-19 Mobile Apps: A Systematic Review of the Literature
Authors: Kondylakis Haridimos , Katehakis Dimitrios G , Kouroubali Angelina , Logothetidis Fokion , Triantafyllidis Andreas , Kalamaras Ilias , Votis Konstantinos , Tzovaras Dimitrios 
Published: October 2020

BackgroundA vast amount of mobile apps have been developed during the past few months in an attempt to “flatten the curve” of the increasing number of COVID-19 cases.ObjectiveThis systematic review aims to shed light into studies found in the scientific literature that have used and evaluated mobile apps for the prevention, management, treatment, or follow-up of COVID-19.MethodsWe searched the bibliographic databases Global Literature on Coronavirus Disease, PubMed, and Scopus to identify papers focusing on mobile apps for COVID-19 that show evidence of their real-life use and have been developed involving clinical professionals in their design or validation.ResultsMobile apps have been implemented for training, information sharing, risk assessment, self-management of symptoms, contact tracing, home monitoring, and decision making, rapidly offering effective and usable tools for managing the COVID-19 pandemic.ConclusionsMobile apps are considered to be a valuable tool for citizens, health professionals, and decision makers in facing critical challenges imposed by the pandemic, such as reducing the burden on hospitals, providing access to credible information, tracking the symptoms and mental health of individuals, and discovering new predictors.
Tietojärjestelmät sairaanhoitajien työn tukena eri toimintaympäristöissä: kokemuksia tuotemerkeittäin
Authors: Kyytsönen Maiju , Hyppönen Hannele , Koponen Samuli , Kinnunen Ulla-Mari , Saranto Kaija , Kivekäs Eija , Kaipio Johanna , Lääveri Tinja , Heponiemi Tarja , Vehko Tuulikki 
Published: October 2020

Asiakas- ja potilastietojärjestelmät ovat sairaanhoitajien työssä keskeisiä työvälineitä. Artikkelissa selvitettiin, missä määrin eri asiakas- ja potilastietojärjestelmät tukevat sairaanhoitajien työtä eri toimintaympäristöissä. Tavoitteena oli tuottaa tietoa kansallisen tiedonhallinnan strategian täyttymisestä ja sairaanhoitajien käyttäjäkokemuksista palautteeksi tietojärjestelmätoimittajille.
Tiedonkeruu sairaanhoitajien tietojärjestelmäkokemuksista toteutettiin keväällä 2020 kyselynä. Kyselyyn vastasi 3912 sairaanhoitajaa, joista pääosa työskenteli julkisessa sairaalassa, terveyskeskuksessa, sosiaalialalla tai yksityissektorilla. Yleisimmin käytettyjä asiakas- ja potilasjärjestelmiä olivat yleisyysjärjestyksessä Lifecare asiakas- ja potilastietojärjestelmä (Lifecare), Uranus, Pegasos, Apotti (tuotemerkki: Epic), Effica terveydenhuolto (Effica), Mediatri, Esko, DynamicHealth ja DomaCare. Kyselyn väittämistä raportoitiin teemoja, jotka koskevat tietojärjestelmien kykyä tukea vuorovaikutusta (4), hyötyjä (4), käytettävyyttä (2), teknistä toimivuutta (3) sekä paperin ja faksin käyttöä (1), tietojärjestelmille annettavia kouluarvosanoja (1) ja järjestelmätoimittajille suoraan annettavaa palautetta (30). Kysely tehtiin sairaanhoitajille toista kertaa, ja pohdinnassa tarkasteltiin muutoksia vuoteen 2017 nähden.
Tulosten mukaan tietojärjestelmien tuki sairaanhoitajien työlle parantui tai pysyi ennallaan monien muuttujien osalta. Tulokset vaihtelivat asiakas- ja potilastietojärjestelmien tuotemerkkien ja toimintaympäristöjen välillä ja myös samojen tuotemerkkien välillä eri toimintaympäristöissä. Sairaanhoitajat olivat tyytyväisiä etenkin tietojärjestelmien kykyyn tukea yhteistyötä ja tiedonkulkua sairaanhoitajien kesken organisaation sisällä sekä sairaanhoitajien ja lääkärien välillä. He myös kokivat, että tietojärjestelmät tuottavat hyötyjä asiakkaiden ja potilaiden hoitoprosessille. Toisaalta organisaatioiden välisessä tiedonkulussa turvauduttiin edelleen paperiin ja faksiin. Lisäksi vastaajat tunnistivat asiakas- ja potilastietojärjestelmissä enemmän työtä hankaloittavia kuin hyvin toimivia ominaisuuksia. Vaikka tietojärjestelmien kehityssuunta vaikutti positiiviselta, eivät ne kaikilta osin edelleenkään tukeneet sairaanhoitajien työtä riittävällä tasolla ja näin ollen tietojärjestelmien systemaattista seurantaa on syytä jatkaa.
The Periodic Table needs negative orbitals in order to eliminate quantum weirdness: a new quantum chemistry mathematics
Authors: Jeffrey H. Boyd  
Published: October 2020

A consensus among quantum experts is that the quantum world is not properly understood. It is a mistake to think we can cure quantum weirdness by tinkering with superficial aspects of quantum mechanics (QM). We propose that nature uses (–ψ) as its wave function, whereas QM uses (+ψ). We propose therefore that the Periodical Table should be changed to negative orbitals (–ψ). Surprisingly, this change makes almost no difference to chemistry on a practical level. The Born rule takes the absolute square of an amplitude to obtain a probability to test in chemistry lab P=|–ψ|2=|+ψ|2. We propose a new math based on (–ψ) that is the mirror image of quantum mathematics. We call it the Theory of Elementary Waves (TEW). The negative sign is not an electrical charge. It has nothing to do with Coulomb’s law. Valence electrons are unchanged. Ions, covalent bonds, dipoles, metals, hydrogen bonding and the hydrogen 21 cm line are unchanged. The octet rule and rules for drawing dot structures of molecules do not change. Amino acids, sugars and DNA do not change their handedness. We cite abundant experimental evidence showing that TEW is correct and QM is wrong.
Observability of Production of tttt quarks at pp-colliders in new physics models
Authors: Abdeljali Habjial  
Published: October 2020

The Standard Model production of four top quarks in the process pp --> tttt at a center-of-mass energy s1/2=13 Tev. The data collected by the ATLAS detector represents an impressive study potential, with an integrated luminosity of around 139 fb-1. In this manuscript, we present the production process of four top quarks at the LHC as well as some new physics models associated with this process. These models are studied in analysis carried. Some preliminary results are presented, in particular those of a new method for estimating background noise due to false leptons developed.
Benefits of Therapeutic Drug Monitoring of First Line Antituberculosis Drugs
Authors: Prso K , Zidekova N , Dohal M , Porvaznik I , Prso M , Kertys M , Mokry J 
Published: October 2020

Abstract
Tuberculosis is an airborne infectious disease that remains a huge global health-related issue nowadays. Despite constant approvals of newly developed drugs, the use of first-line antituberculosis medicines seems reasonable in drug-susceptible Mycobacterium tuberculosis strains. Therapeutic drug monitoring presents a useful technique for the determination of plasma drug concentration to adjust appropriate dose regimes. In tuberculosis treatment, therapeutic drug monitoring is aiding clinicians in selecting an optimal therapeutic level, which is essential for the personalisation of therapy. This review is aimed at clarifying the use of therapeutic drug monitoring of the first-line antituberculosis drugs in routine clinical practice.
Synthesis and Characterization of Physical Properties of the NiO Thin Films by Various Concentrations
Authors: Maaoui B. , Aoun Y. , Benramache S. , Nid A. , Far R. , Touati A. 
Published: October 2020

Abstract
In this work, nickel oxide was deposited on a glass substrate at by spray deposition technique; the structural, optical and electrical properties were studied at different NiO concentrations (0.05, 0.10 and 0.15 mol.l−1). Polycrystalline NiO films with a cubic structure with a strong (111) preferred orientation were observed at all sprayed films with minimum crystallite size of 11.97 nm was attained of deposited film at 0.1 mol.l−1. However, α-Ni(OH)2 was observed at 0.15 mol.l−1. The NiO thin films have good transparency in the visible region, the band gap energy varies from 3.54 to 376 eV was affected by NiO concentration, it is shown that the NiO thin film prepared at 0.05 mol.l−1 has less disorder with few defects. The NiO film deposited at 0.15 mol.l−1 has the electrical conductivity was 0.169 (Ω.cm)−1.
Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture
Authors: Javorac Dragana , Đorđević Aleksandra Buha , Anđelković Milena , Tatović Simona , Baralić Katarina , Antonijević Evica , Kotur-Stevuljević Jelena , Đukić-Ćosić Danijela , Antonijević Biljana , Bulat Zorica 
Published: October 2020

Abstract
Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.
Capillary bacterial migration on non-nutritive solid surfaces
Authors: Ivanković Tomislav , Hadad Uzi , Kushmaro Ariel , Dekić Svjetlana , Ćevid Josipa , Percela Marko , Hrenović Jasna 
Published: October 2020

Abstract
Here we describe an additional type of bacterial migration in which bacterial cells migrate vertically across a non-nutritive solid surface carried by capillary forces. Unlike standard motility experiments, these were run on a glass slide inserted into a Falcon tube, partly immersed in a nutrient medium and partly exposed to air. Observations revealed that capillary forces initiated upward cell migration when biofilm was formed at the border between liquid and air. The movement was facilitated by the production of extracellular polymeric substances (EPS). This motility differs from earlier described swarming, twitching, gliding, sliding, or surfing, although these types of movements are not excluded. We therefore propose to call it “capillary movement of biofilm”. This phenomenon may be an ecologically important mode of bacterial motility on solid surfaces.
On the Radon-Nikodym Property for Vector Measures and Extensions of Transfunctions
Authors: Mikusiński Piotr , Ward John Paul 
Published: October 2020

Abstract
If

(

μ

n

)

n
=
1

∞

\left( {{\mu _n}} \right)_{n = 1}^\infty

are positive measures on a measurable space (X, Σ) and

(

v

n

)

n
=
1

∞

\left( {{v_n}} \right)_{n = 1}^\infty

are elements of a Banach space 𝔼 such that

∑

n
=
1

∞

‖

v

n

‖

μ

n

(
X
)

<
∞

\sum\nolimits_{n = 1}^\infty {\left\| {{v_n}} \right\|{\mu _n}\left( X \right)} < \infty

, then

ω

(
S
)

=

∑

n
=
1

∞

v

n

μ

n

(
S
)

\omega \left( S \right) = \sum\nolimits_{n = 1}^\infty {{v_n}{\mu _n}\left( S \right)}

defines a vector measure of bounded variation on (X, Σ). We show 𝔼 has the Radon-Nikodym property if and only if every 𝔼-valued measure of bounded variation on (X, Σ) is of this form. This characterization of the Radon-Nikodym property leads to a new proof of the Lewis-Stegall theorem.
We also use this result to show that under natural conditions an operator defined on positive measures has a unique extension to an operator defined on 𝔼-valued measures for any Banach space 𝔼 that has the Radon-Nikodym property.
Microservices Centric Architectural Model for Handling Data Stream Oriented Applications
Authors: Philip Milu Mary , Seshadri Amrutha , Vijayakumar B. 
Published: October 2020

Abstract
The present-day software application systems are highly complex with many requirements and variations, which can only be handled by more than one architectural pattern. This paper focuses on a combinational architectural design, with the micro-services at the center and supported by the model view controller and the pipes and filter architectural patterns to realize any data stream-oriented application. The proposed model is very generic and for validation, a prototype GIS application has been considered. The application is designed to extract GIS data from internet sources and process the data using third party processing tools. The overall design follows the micro-services architecture and the processing segment is designed using pipes-and-filters architectural pattern. The user interaction is made possible with the use of the model view controller pattern. The versatility of the application is expressed in its ability to organize any number of given filters in a connected structure that agrees with inter-component dependencies. The model includes different services, which make the application more user-friendly and secure by prompting client for authentication and providing unique storage for every client. This approach is very much useful for building applications with a high degree of flexibility, maintainability and adaptability. A qualitative comparison is made using a set of criteria and their implementation using the different architectural styles.
Employing Divergent Machine Learning Classifiers to Upgrade the Preciseness of Image Retrieval Systems
Authors: Dhingra Shefali , Bansal Poonam 
Published: October 2020

Abstract
Content Based Image Retrieval (CBIR) system is an efficient search engine which has the potentiality of retrieving the images from huge repositories by extracting the visual features. It includes color, texture and shape. Texture is the most eminent feature among all. This investigation focuses upon the classification complications that crop up in case of big datasets. In this, texture techniques are explored with machine learning algorithms in order to increase the retrieval efficiency. We have tested our system on three texture techniques using various classifiers which are Support vector machine, K-Nearest Neighbor (KNN), Naïve Bayes and Decision Tree (DT). Variant evaluation metrics precision, recall, false alarm rate, accuracy etc. are figured out to measure the competence of the designed CBIR system on two benchmark datasets, i.e. Wang and Brodatz. Result shows that with both these datasets the KNN and DT classifier hand over superior results as compared to others.
Towards a Multistep Method for Assessment in e-Learning of Emerging Technologies
Authors: Popchev Ivan P. , Orozova Daniela A. 
Published: October 2020

Abstract
In the Fourth Industrial Revolution some important leading technologies are identified as emerging technologies with unknown in advance potential risks. Emphasized is the need for new approaches and solutions for forming of increased information awareness, knowledge and competencies in the present and future generations to use the possibilities of Industry 4.0 for technological breakthroughs. A method for evaluation and prognosis of the knowledge, skills and competencies of the students in the virtual education space is proposed in the form of a five-step process. The method can be adapted to new technologies and applications. Research and analysis of the method are carried out in the academic course ‘Artificial Intelligence’ at the Burgas Free University with the application of the instruments of the Orange system for experimentation and inference.
Phytochemical and antioxidant activities of methanolic extract of Lawsonia inermis L. Bark
Authors: Golwala Dharmesh K. , Vaidya Santosh Kumar , Patel Timir B , Patel Darpini S. , Dholwani Kishor K. 
Published: October 2020

Abstract
Many diseases are associated with oxidative stress are caused by free radicals. Current research has been directed towards finding naturally occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of methanolic extract of Lawsonia inermis L. bark (MELIB). The present study was carried out for determination of qualitative, quantitative phytochemical and in vitro antioxidant activity for scavenging of free radical DPPH, superoxide radical scavenging and lipid peroxidation. The bark extract is a rich source of secondary metabolites like flavonoids at a rutin equivalent 73.43±0.26%, polyphenol at a gallic acid equivalent 84.70±0.43%, tannins at a tannic acid equivalent 88.75±0.14% and terpenoids at a linalool equivalent 68.13±0.31. MELIB showed free radicals scavenging capacity by way of the DPPH method (6.93±0.51 to 62.63±0.10% inhibition), the superoxide radical scavenging method (1.82±0.41 to 57.11±0.18% inhibition) and the ferric chloride induced lipid peroxidation method (9.87±0.33 to 80.32±0.82% inhibition). The results obtained in the present study indicate that MELIB can be a potential source of natural antioxidants due to the presence of flavonoids, polyphenols, tannins and terpenoids.
The effect of a selective estrogen receptor modulator – raloxifene – on the levels of tryptophan and kynurenic acid in the livers of rats as studied via RP-HPLC-FL
Authors: Flieger Jolanta , Pizon Magdalena , Kowalska-Kepczynska Anna , Smolinska Katarzyna , Paluszkiewicz Piotr 
Published: October 2020

Abstract
The levels of tryptophan (TRP) and its main metabolite kynurenic acid (KYNA) were measured in rat livers treated with raloxifene – a selective estrogen receptor modulator. The research was conducted by applying high-performance liquid chromatography on a 5 μm Zorbax Eclipse XDB-C18 column. Selective fluorescence detection (FL) was performed at an excitation of 219 nm and emission of 360 nm for TRP and KYNA. The assays showed good linearity (R2 >0.95) within the tested ranges of 0.045-0.20 µg mL−1, 0.025-0.32 µg mL−1, respectively, for KYNA and TRP. The limits of the detection were found to be 0.1480 ng mL−1 for KYNA and 0.0332 ng mL-1 for TRP. The deproteinization of the liver homogenate samples was accomplished by 80% methanol addition combined with boiling precipitation. The average recovery values were between 94.84% and 99.54% with RSDs no more than 5.5%. The work revealed that raloxifene decreased the mean value of tryptophan, as compared with the control group, while simultaneously leaving kynurenic acid at the same level. For the first time the research suggests that, in the case of raloxifene therapy, tryptophan is not metabolized via the kynurenine pathway.
Growth and Mortality of Green Mussel Perna viridis Farmed at Ambong Bay and Marudu Bay, Sabah, Malaysia
Authors: Isnain Irman , Manjaji-Matsumoto B. Mabel , Ransangan Julian , Mustapha Shuhadah 
Published: October 2020

Abstract
Asian green mussel is commercially farmed in tidal waters in several enclosed bays in Sabah, Malaysia. In this study, two areas on the west coast of Sabah – Ambong Bay and Marudu Bay – were selected for the monitoring of the growth and mortality rates of green mussels farmed in suspension raft. Both growth and survival rates were then correlated with physicochemical parameters (dissolved oxygen, pH, salinity, temperature, water transparency, chlorophyll-a), nutrients (phosphate (PO4
3-), ammonia (NH3-N), nitrate (NO3-N) and nitrite (NO2-N) and condition index of mussel from each study site, as well as between the study sites. The twelve-month growth study (September 2017 to August 2018) was started with a total of 180 mussel specimens (90 at each site). The initial size (mean) of the mussel seed used was 47.7 ± 3.5 mm and 51.1 ± 3.9 mm for Marudu Bay and Ambong Bay, respectively. Mussels in Marudu Bay attained mean size of 73.47 ± 11.05 mm (SGR 0.17% ± 0.22) compared to 64.05 ± 7.44 mm (SGR 0.11% ± 0.22) for Ambong Bay at the end of the experiment. The cumulative mortality rates were 9.2% ± 4.9 and 55.5% ± 30.0 for Marudu Bay and Ambong Bay, respectively. The Pearson correlation indicated a significant positive relationship between mortality and water transparency (r = 0.684, p<0.01). There was a significant negative relationship between ammonia in seawater and mussel mortality (r = -0.561, p<0.01), as well as significant negative relationships between nitrate and growth (r = -0.480, p<0.05) and mortality (r = -0.460, p<0.05), as indicated by Spearman’s Rank-order Correlation analysis. Overall, the growth performance of green mussels farmed in Marudu Bay was better than in Ambong Bay, however, the mortality of mussels in Ambong Bay was higher.