bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of human papillomavirus status after conization for high‐grade cervical intraepithelial neoplasia
Authors: Huang Huei‐Jean , Tung Hsiu‐Jung , Yang Lan‐Yan , Chao Angel , Tang Yun‐Hsin , Chou Hung‐Hsueh , Chang Wei‐Yang , Wu Ren‐Chin , Huang Chu‐Chun , Lin Chiao‐Yun , Liao Min‐Jie , Chen Wei‐Chun , Lin Cheng‐Tao , Chen Min‐Yu , Huang Kuan‐Gen , Wang Chin‐Jung , Chang Ting‐Chang , Lai Chyong‐Huey 
Published: August 2020

AbstractHuman papillomavirus (HPV) is the well‐established etiologic factor for cervical neoplasia. Cervical conization constitutes an effective treatment for high‐grade cervical intraepithelial neoplasia (HG‐CIN). We conducted an observational study for long‐term outcomes and HPV genotype changes after conization for HG‐CIN. Between 2008 and 2014, patients with newly diagnosed HG‐CIN before conization (surveillance new [SN] group) and those who had undergone conization without hysterectomy (surveillance previous [SP] group) were enrolled. HPV testing and Pap smear were performed periodically for the SN and SP (collectively S) groups. All other patients receiving conization for HG‐CIN during the study period were identified from our hospital database. Those eligible but not enrolled into our study were assigned to the non‐surveillance (non‐S) group. For the S group (n = 493), the median follow‐up period was 74.3 months. Eighty‐four cases had recurrent CIN Grade 2 or worse (CIN2+) (5‐year cumulative rate: 14.8%), of which six had invasive cancer. Among the 84 patients, 65 (77.4%) exhibited type‐specific persistence in the paired HPV results, whereas only 7 (8.3%) harbored new HPV types that belonged to the 9‐valent vaccine types. Among the 7397 non‐S patients, 789 demonstrated recurrent CIN2+, of which 57 had invasive cancer. The stages distribution of those progressed to invasive cancer in the non‐S group were more advanced than the S group (P = .033). Active surveillance might reduce the severity of those progressed to cancer. Because a majority of the patients with recurrent CIN2+ had persistent type‐specific HPV infections, effective therapeutic vaccines are an unmet medical need.
Credit information sharing and bank loan pricing: Do concentration and governance matter?
Authors: Fosu Samuel , Danso Albert , Agyei‐Boapeah Henry , Ntim Collins G. 
Published: August 2020

AbstractThe development of credit information sharing schemes in developing countries has gained significant attention in recent times along with ongoing financial sector reforms. In this paper, we provide first‐hand evidence of the effect of credit information sharing on credit intermediation cost in these countries, and consequently ascertain the extent to which the credit information sharing–credit intermediation cost nexus may be accentuated by banking market concentration and governance quality. Using a large dataset covering 272 banks from 27 African countries over the 2004–2012 period, we uncover four new findings. First, we find that credit information sharing does reduce credit intermediation cost. Second, we show that the relationship between credit intermediation cost and credit information sharing is conditional on banking market concentration. Third, our findings suggest that governance quality moderates the effect of credit information sharing on credit intermediation cost. Finally, we find that banking market concentration reduces credit intermediation cost, but the effect is moderated by credit information sharing. Overall, our findings suggest that credit information sharing may serve as a useful policy tool for achieving financial sector stability in developing countries.
Impact of demographic factors on the financial performance of women‐owned micro‐enterprises in India
Authors: Harpriya  , Sharma Rakesh Kumar , Sah Ash Narayan 
Published: August 2020

AbstractThis paper studies the impact of demographic factors on the performance of women‐owned micro‐enterprises in North India. Data were collected from 100 women entrepreneurs through self‐structured questionnaire using stratified random sampling technique. Sales turnover and net profit margin are taken as dependent variables. Multivariate regression analysis was applied to study the impact of various demographic factors. The results indicate registration status, legal ownership, nature of business, age, education, family income, size of business and employees positively affect the net profits and sales turnover of the enterprises. However, the numbers of products offered have a negative effect on the sales and net profits margin. The factors identified in this study, which have a positive impact on the net profits and sales turnover, are important in making entrepreneurial decisions that can enhance the performance and may help for economical production.
Heparin/collagen surface coatings modulate the growth, secretome, and morphology of human mesenchymal stromal cell response to interferon‐gamma
Authors: Cifuentes Said J. , Priyadarshani Priyanka , Castilla‐Casadiego David A. , Mortensen Luke J. , Almodóvar Jorge , Domenech Maribella 
Published: August 2020

AbstractThe therapeutic potential of human mesenchymal stromal cells (h‐MSC) is dependent on the viability and secretory capacity of cells both modulated by the culture environment. Our previous studies introduced heparin and collagen I (HEP/COL) alternating stacked layers as a potential substrate to enhance the secretion of immunosuppressive factors of h‐MSCs. Herein, we examined the impact of HEP/COL multilayers on the growth, morphology, and secretome of bone marrow and adipose‐derived h‐MSCs. The physicochemical properties and stability of the HEP/COL coatings were confirmed at 0 and 30 days. Cell growth was examined using cell culture media supplemented with 2 and 10% serum for 5 days. Results showed that HEP/COL multilayers supported h‐MSC growth in 2% serum at levels equivalent to 10% serum. COL and HEP as single component coatings had limited impact on cell growth. Senescent studies performed over three sequential passages showed that HEP/COL multilayers did not impair the replicative capacity of h‐MSCs. Examination of 27 cytokines showed significant enhancements in eight factors, including intracellular indoleamine 2, 3‐dioxygenase, on HEP/COL multilayers when stimulated with interferon‐gamma (IFN‐γ). Image‐based analysis of cell micrographs showed that serum influences h‐MSC morphology; however, HEP‐ended multilayers generated distinct morphological changes in response to IFN‐γ, suggesting an optical detectable assessment of h‐MSCs immunosuppressive potency. This study supports HEP/COL multilayers as a culture substrate for undifferentiated h‐MSCs cultured in reduced serum conditions.
The CKD-MBD Syndrome: Hysteresis in PTH Involvement and PTH Administration for Its Management
Authors: Pazianas Michael , Miller Paul D 
Published: August 2020

ABSTRACT
Chronic kidney disease (CKD) disturbs mineral homeostasis, leading to mineral and bone disorders (MBD). CKD-MBD is a significant problem and currently available treatment options have important limitations. Phosphate retention is thought to be the initial cause of CKD-MBD but serum phosphate remains normal until the late stages of CKD, due to elevated levels of the phosphaturic hormone fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). Reduction of 1,25-dihydroxy-vitamin D (1,25[OH]2D) concentration is the next event in the adaptive response of the homeostatic system. We argue, and provide the rationale, that calcium retention which takes place concurrently with phosphate retention, could be the reason behind the hysteresis in the response of PTH. If indeed this is the case, intermittent administration of PTH in early CKD could prevent the hysteresis, which arguably leads to the development of secondary hyperparathyroidism, and provide the platform for an effective management of CKD-MBD. © 2020 American Society for Bone and Mineral Research (ASBMR).
Cardiovascular Safety of Denosumab Across Multiple Indications: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Seeto Alexander H , Abrahamsen Bo , Ebeling Peter R , Rodríguez Alexander J 
Published: August 2020

ABSTRACT
The cardiovascular safety of denosumab has not yet been evaluated in a systematic review. This systematic review and meta-analysis sought to quantify the number of randomized controlled trials (RCTs) of denosumab (against comparators) reporting cardiovascular adverse events (CAEs) and examine the balance of CAEs between treatment arms. MEDLINE, Embase, and clinicaltrials.gov were searched from inception to October 26, 2019, for RCTs of denosumab versus comparators for any indication. Included trials were randomized, enrolled ≥100 participants, and reported bone-related outcomes. Primary outcome for analysis was all CAEs, a composite endpoint representing summation of all CAEs as reported by included trials. Secondary outcomes included major adverse cardiovascular events (MACE). Data were pooled using a fixed effects model to determine relative risk (RR) and 95% confidence interval (95% CI). Risk of bias was assessed using the Cochrane risk-of-bias tool. Of 554 records screened, 49 were included, while 36 reported CAEs. Twenty-seven included trials (12 eligible for meta-analysis) were conducted in 13,202 postmenopausal women. Compared with bisphosphonates, there was a 46% (95% CI 1.05 to 2.02) increase in CAEs (85/2136 events in denosumab-treated versus 58/2131 events in bisphosphonate-treated; seven trials). There was a similar imbalance in a five-point (stroke, myocardial infarction, cardiovascular death, heart failure, atrial fibrillation) MACE endpoint (28/2053 versus 12/2050; RR = 2.33 [1.19 to 4.56]). Compared with placebo-treated women, there was no imbalance in total CAEs (439/4725 events in denosumab versus 399/4467 in placebo; RR = 0.79 [0.41 to 1.52]; seven trials). No imbalance in total AEs (versus bisphosphonates: 0.98 [0.92 to 1.04]; versus placebo: 0.99 [0.98 to 1.01]) occurred. Other indications showed no statistically significant results. The excess CAEs in postmenopausal women treated with denosumab compared with bisphosphonates, but not placebo, indirectly supports claims that bisphosphonates may suppress CAEs. Future trials should use standardized CAE reporting to better describe cardiovascular effects of bone active medications. (PROSPERO: CRD42019135414.) © 2020 American Society for Bone and Mineral Research (ASBMR).
Effect of dentin and fiber post surface treatments with fumaric acid on the bonding ability of fiber posts
Authors: Saricam Esma , Arslan Merve 
Published: August 2020

AbstractThis study investigated the effects of fumaric acid on push‐out bond strength when applied to dentin surfaces and fiber posts. The root canals of 60 mandibular premolar teeth were instrumented and obturated. After removing two thirds of filling material, teeth were prepared according to six randomized groups (n = 10/group) defined by two fiber post surface treatments (0.7% fumaric acid or 9% hydrofluoric acid) and three dentin conditioning treatments [control (no conditioning); 17% ethylenediamine tetraacetic acid (EDTA); or 0.7% fumaric acid]. After fiber post‐cementation, three 1‐mm thick discs were obtained from each tooth by transverse sectioning, and each disc underwent push‐out bond strength testing. Data were analyzed with a one‐way analyses of variance (anova) and t tests; p < .05 was considered statistically significant. Failure modes were determined by stereomicroscopy, and the surface characteristics of dentin and fiber posts were observed by scanning electron microscopy. Push‐out bond strength was greater for the group in which the post surface treated with hydrofluoric acid and the dentin surface treated with fumaric acid than the nontreated dentin and hydrofluoric acid‐treated post group (p < .05). There were no significant differences between other comparison pairs (p > .05). A combination of fumaric acid dentin conditioning and hydrofluoric acid fiber post treatment strengthened the bonding ability of fiber posts.
Global Research Alliance N2O chamber methodology guidelines: Guidelines for gap‐filling missing measurements
Authors: Dorich Christopher D. , De Rosa Daniele , Barton Louise , Grace Peter , Rowlings David , Migliorati Massimiliano De Antoni , Wagner‐Riddle Claudia , Key Cameron , Wang Daqi , Fehr Benjamin , Conant Richard T 
Published: August 2020

AbstractNitrous oxide (N2O) is a potent greenhouse gas that is primarily emitted from agriculture. Sampling limitations have generally resulted in discontinuous N2O observations over the course of any given year. The status quo for interpolating between sampling points has been to use a simple linear interpolation. This can be problematic with N2O emissions, since they are highly variable and sampling bias around these peak emission periods can have dramatic impacts on cumulative emissions. Here, we outline five gap‐filling practices: linear interpolation, generalized additive models (GAMs), autoregressive integrated moving average (ARIMA), random forest (RF), and neural networks (NNs) that have been used for gap‐filling soil N2O emissions. To facilitate the use of improved gap‐filling methods, we describe the five methods and then provide strengths and challenges or weaknesses of each method so that model selection can be improved. We then outline a protocol that details data organization and selection, splitting of data into training and testing datasets, building and testing models, and reporting results. Use of advanced gap‐filling methods within a standardized protocol is likely to increase transparency, improve emission estimates, reduce uncertainty, and increase capacity to quantify the impact of mitigation practices.
INCOME CONVERGENCE IN INDIAN DISTRICTS: NEW EVIDENCE FROM PANEL STATIONARITY TEST WITH FINITE TIME DIMENSION
Authors: Misra Biswa Swarup , Kar Muhsin , Nazlioglu Saban , Karul Cagin 
Published: August 2020

AbstractThis paper tests for income convergence at the district level in India taking into account district income for 388 districts in 12 states during 2001–2011. We study income convergence among districts within a state as well districts across states that share similar initial conditions. Given the finite sample property of the data, we conduct a novel panel stationarity test with a fixed time dimension. The findings do not support the convergence of the per capita district income in Indian states. The deterioration in economic and social infrastructure in the relatively backward districts during the study period seems to drive the results. © 2020 John Wiley & Sons, Ltd.
Nonstationary relationship between sea ice overKara–Laptevseas duringAugust–Septemberand Ural blocking in the following winter
Authors: Wang Sai , Nath Debashis , Chen Wen 
Published: August 2020

AbstractIn the current manuscript, we investigate the relationship between sea‐ice extent (August–September) over Kara–Laptev Seas (SIEKL) and the variability of Ural blocking in the following winter months (December–February, DJF). It is found that the linkage between SIEKL and Ural blocking in the following winter arises partly due to the influence of barotropic teleconnection pattern, emanated from the east coast of North America. The teleconnection can influence the mean Kara–Laptev sea ice variability during August–September. The memory of this teleconnection in the sea surface temperature (SST) anomalies over the North Atlantic Ocean further influences the Ural blocking in the following winter. The relationship between the SIEKL and Ural blocking has experienced a significant interdecadal change around mid‐1990s. The SIEKL‐related positive geopotential height anomalies over the Ural Mountains in the following winter are stronger during 1979–1996 period compare to the 1997–2017 periods. The differences in geopotential height anomalies between the two periods are related to the differences in the strength of synoptic‐scale eddy feedback. The feedback is stronger in the earlier period, which is conductive to the maintenance and amplification of positive geopotential height anomalies over the Ural Mountains, whereas the feedback is weaker in the later period. Further analysis suggests that the weakening of synoptic‐scale eddy feedback is due to weakening in the intensity of wintertime synoptic‐scale eddy activity on an interdecadal scale over the Barents Sea and northern Siberian sector.
Combined impacts of the El Niño‐Southern Oscillation and Pacific Decadal Oscillation on global droughts assessed using the standardized precipitation evapotranspiration index
Authors: Nguyen Phuong‐Loan , Min Seung‐Ki , Kim Yeon‐Hee 
Published: August 2020

AbstractUsing the standardized precipitation evapotranspiration index, this study examines the combined effects of El Niño‐Southern Oscillation (ENSO) and Pacific Decadal Oscillation (PDO) on global droughts in terms of magnitude, timing, and duration. The ENSO‐affected drought hotspots are identified based on drought magnitude and probability of occurrence: five hotspots for El Niño (Amazon, India, central China, Indonesia, and eastern Australia) and four hotspots for La Niña (southeastern United States, southern South America, East Africa, and Southwest Asia). When ENSO and PDO are in phase, most of the hotspots exhibit an intensification and expansion of drought, more clearly at longer time scales (6–12 months), supporting previous studies. Interestingly, the in‐phase PDO advances El Niño‐induced drought onset by early summer of the previous year, whereas it delays the withdrawal of La Niña‐induced drought until the end of the event year. This asymmetric response is found to be in part associated with the earlier start and later end of El Niño itself during warm PDO, which does not hold for the La Niña/cold PDO composites. Further analyses of the responses of precipitation (P) and potential evapotranspiration (PET) to different ENSO‐PDO combinations suggest the important role of P reduction in determining drought magnitude and timing over most of the hotspots, with some contribution of enhanced PET to drier conditions over a few La Niña hotspots. It is also found that the PDO modulation of El Niño‐induced drought occurs primarily through the eastern Pacific El Niño with a limited influence on the central Pacific El Niño.
Lysosomal disruption by orthopedic wear particles induces activation of the NLRP3 inflammasome and macrophage cell death by distinct mechanisms
Authors: Fort Brian P. , Dubyak George R. , Greenfield Edward M. 
Published: August 2020

AbstractWear particles from orthopedic implants cause aseptic loosening, the leading cause of implant revisions. The particles are phagocytosed by macrophages leading to activation of the nod‐like receptor protein 3 (NLRP3) inflammasome and release of interleukin‐1β (IL‐1β) which then contributes to osteoclast differentiation and implant loosening. The mechanism of inflammasome activation by orthopedic particles is undetermined but other particles cause the cytosolic accumulation of the lysosomal cathepsin‐family proteases which can activate the NLRP3 inflammasome. Here, we demonstrate that lysosome membrane disruption causes cathepsin release into the cytoplasm that drives both inflammasome activation and cell death but that these processes occur independently. Using wild‐type and genetically‐manipulated immortalized murine bone marrow derived macrophages and pharmacologic inhibitors, we found that NLRP3 and gasdermin D are required for particle‐induced IL‐1β release but not for particle‐induced cell death. In contrast, phagocytosis and lysosomal cathepsin release are critical for both IL‐1β release and cell death. Collectively, our findings identify the pan‐cathepsin inhibitor Ca‐074Me and the NLRP3 inflammasome inhibitor MCC950 as therapeutic interventions worth exploring in aseptic loosening of orthopedic implants. We also found that particle‐induced activation of the NLRP3 inflammasome in pre‐primed macrophages and cell death are not dependent on pathogen‐associated molecular patterns adherent to the wear particles despite such pathogen‐associated molecular patterns being critical for all other previously studied wear particle responses, including priming of the NLRP3 inflammasome.
Sensory characteristics and volatile compounds of dry cured ham Speck are affected by pig dietary supplementation with antioxidant mixture
Authors: Rossi Raffaella , Ratti Sabrina , Moretti Vittorio M , Vasconi Mauro , Corino Carlo 
Published: August 2020

AbstractBACKGROUNDDry cured ham named Speck is a typical Italian product, with consolidated processing techniques and specific quality parameters. It has gained importance in the international market after obtaining the Protected Geographical Indication. Recent studies indicate that dietary plant extracts in pig may affect quality of processed meats but there are no data on their effect on Speck. Consequently, the effects of dietary supplementation with antioxidant mixture (AOX), containing vitamin E and polyphenols, in pigs on the nutritional characteristics, volatile compounds, sensory properties and consumers' preference of Speck were evaluated.RESULTSThe Speck weight loss during seasoning was lower in the AOX group, while products quality parameters were not affected by dietary treatments. Alcohol and terpenes concentrations were lower (P < 0.05) in the AOX samples than the control. Sensory profile revealed slight differences (P < 0.05) in Speck salty and sweet taste, whereas the consumer tests showed a higher (P < 0.05) preference, with mean score of seven, for Speck from pigs fed AOX.CONCLUSIONOur results provide new insights on the quality parameters of Speck. Dietary integration with antioxidant mixture decreased Speck weight losses during seasoning. Volatile compounds concentrations and sensory profile were slightly affected by dietary treatment. The consumer test revealed that dietary antioxidants, increased the overall preference for Speck, and can potentially increase its consumption. © 2020 Society of Chemical Industry
Evaluation and optimization of the derivatization reaction conditions of glyphosate and aminomethylphosphonic acid with 6‐aminoquinolyl‐N‐hydroxysuccinimidyl carbamate using reversed‐phase liquid chromatography
Authors: Fontàs Clàudia , Sanchez Juan M. 
Published: August 2020

AbstractDue to the polar and ionic characteristics of glyphosate and its main metabolite, aminomethylphosphonic acid, a derivatization reaction is required before performing liquid chromatographic determination of these compounds. In this study, reaction conditions using 6‐aminoquinolyl‐N‐hydroxysuccinimidyl carbamate as the derivatization reagent are assessed. A two‐level full‐factorial design is applied here to optimize the derivatization time (ranging from 0.5 to 20 min) and temperature (from 24 to 55°C). It is found that neither of these two variables have a significant effect on the derivatization process and that the reaction is quantitatively achieved in a few seconds at room temperature (24°C). The results obtained indicate that derivatization reaction with 6‐aminoquinolyl‐N‐hydroxysuccinimidyl carbamate is achieved in milder conditions, with a faster kinetic reaction, than those required with the most conventional derivatization reagents used today, and the derivatives are more stable. It has been found that the most important parameter affecting the chromatographic separation is the pH of the mobile phase, as it has a significant effect on the retention time of the hydrolyzed excess of reagent. When ammonium acetate is used in the mobile phase, buffered solutions at pH around 5.0 are required.