bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectrophotometric Determination of Phenylephrine Macromolecule by Coupling with Diazotized 4‐Bromo Aniline
Authors: Sharif Assen N. , Mohammed Asmaa Ahmed 
Published: February 2025

AbstractThe present study outlines a meticulously devised and accurate spectrophotometric method for the determination of phenylephrine hydrochloride (PHEPH) in both its pure drug form and drop formulation. The methodology hinges upon a diazo‐coupling reaction, whereby PHEPH undergoes coupling with diazotized 4‐bromoaniline under alkaline conditions. The resulting yellowish‐orange azo‐dye demonstrates a remarkable sensitivity, quantified by the molar absorptivity value of 4.684 × 103 L mol−1 cm−1. The pinnacle of absorption occurs at 459 nm, and the linearity of the method is impeccably upheld within the concentration range of 3–48 µg 10 mL−1 of PHEPH, as dictated by Beer's law. An aspect of paramount significance is the enduring stability of the product's coloration, evincing minimal alteration in absorbance over duration of up to 60 min. Notably, the recovery percentage stands at an impressive 100.1376%, testifying to the method's accuracy, while the relative standard deviation (RSD%) of a mere 0.310178% underscores its precision. The applicability of this method extends seamlessly to the estimation of PHEPH within nasal drop formulations, yielding results of commendable reliability and consistency.
Synthesis and Characterization of Silver(I) Macromolecules Containing Macrocyclic Dithiocarbamate Ligand and Phosphines
Authors: Omar Hala Wathik , Mohammed Modher Y. , Ismail Yaseen Asra'a 
Published: February 2025

AbstractThis study delineates the synthesis of a series of macrocyclic dinuclear metal dithiocarbamate‐based complexes. The synthesis methodology encompasses the preparation of sodium uracil bis dithiocarbamate (U‐DTC) by a controlled addition of carbon disulfide (CS2) to uracil within a NaOH medium under refrigerated conditions (0–5 °C). The resultant U‐DTC ligand serves as the foundation for novel Ag(I) complexes, incorporating phosphine ligands, specifically dppe and dppp, at a stoichiometric ratio of 2:1 (phosphine: metal). Additionally, complexes are formed with PPh3 at a ratio of 4:1 (phosphine: metal). Detailed characterization through spectroscopic methodologies, including FTIR, 1H‐NMR, and 13C‐NMR analyses, reveals the coordination mode of U‐DTC with the Ag center. The spectroscopic evidence confirms the attachment of U‐DTC to the silver center through a bidentate fashion, involving both sulfur atoms in a chelating manner. This synthetic approach underscores the strategic utilization of U‐DTC as a precursor to engineer novel Ag(I) complexes, employing phosphine ligands in controlled ratios. The spectroscopic elucidation of the coordination mode provides crucial insights into the structural arrangement and bonding characteristics within the synthesized complexes, offering a foundation for further exploration and application of these complexes in diverse chemical contexts.
Environmental Concerns of Chemical Materials Usage: Balancing Progress and Law
Authors: Jameel Rahma R. , Jubair Ali A. , Hussain Ream A. , Nuaman Huda A. , Alheety Mustafa A. 
Published: February 2025

AbstractThe surge in chemical usage outside governorate centers has become a focal point of concern due to its profound environmental impact and potential threats to public safety. This comprehensive article delves into the intricate dynamics of this issue, exploring the current landscape of chemical usage trends, and their environmental repercussions. It critically assesses the existing legal framework on both national and international levels, highlighting challenges in enforcement and the associated public health, and safety concerns. The discussion extends to proposed reforms, emphasizing the need for a strengthened legal framework, and increased community engagement. Case studies offer valuable insights, examining successful models and failures that shape lessons for future policymaking. The article further explores the role of technological advancements in enhancing monitoring and regulatory efforts and advocates for collaborative approaches involving government bodies, industries, and local communities. In conclusion, the article underscores the necessity of finding a delicate balance between economic progress and environmental responsibility. Through a multifaceted approach that incorporates legal reforms, technological innovations, and collaborative strategies, the future outlook envisions a harmonious coexistence of development and sustainability in the regulation of chemical usage outside governorate centers.
Synthesis and In Silico Study of Silver Nanoparticles Composite with Novel Schiff Base
Authors: Alheety Nuaman F. , Yassin Hanan Altaif , Karakosh Ahmed J. , Aldahham Bilal J. M. , Ali Samer H. , Ahmed Khalid Dfeek , Dylan Bilal A. , Nuaman Huda A. , Alheety Mustafa A. 
Published: February 2025

AbstractThe study includes preparations of compound N1 (hydrazinecarbothiohydrazide) that is yielded from reacting carbon disulfide with 80% aqueous hydrazine. The resulting compound is used to prepare N2 (MBHCH) by the treatment of N1 with compound 4‐(methylthio)benzaldehyde. The newly prepared compound is Schiff base (N2). Furthermore, silver nanoparticles (N3) are prepared by the reaction of silver nitrate with aqueous extract of Stachys arabica leaves (reducing agent). Reacting of silver nanoparticles with compound N2 gave the compound N4. The prepared compounds are characterized using various techniques FT‐IR, 1H‐NMR, XRD and TEM. Moreover, the DFT, ADMET, and molecular docking are examined for the organic molecules. The results prove that the docking scores are −7.40, −5.83, and −5.98 against tyrosyl‐tRNA synthetase (S. aureus), peptidoglycan glycosyltransferase (E. coli), and AcrAB‐TolC efflux pump (E. coli).
Micro‐Determination of the Macro‐Drugs (Pseudoephedrine Hydrochloride‐Ibuprofen) in their Pure Form and Pharmaceutical Preparations
Authors: Jabouri Asmaa Saeed , Attia Khalf Fares 
Published: February 2025

AbstractMicro‐drug estimation is performed on pseudoephedrine hydrochloride and ibuprofen macromolecules. The third‐order spectrum derivation technique revealed a linearity range of 20–50 µg/mL for both ibuprofen (Ibu) and pseudoephedrine (Psed). A uniform scaling factor of 10 is applied across all drugs. The limits of detection (LOD%) ranged from 0.12366 to 4.73181, and the limits of quantification (LOQ%) ranged from 0.370454 to 14.3388. The relative standard deviation (RSD%) values varied from 0.002779 to 0.020325, while the recovery (Rec%) values ranged between 96.8 and 100.734. Specifically, for ibuprofen and pseudoephedrine, the LOD% values are between 0.370454 and 14.3388, the RSD% values ranged from 0.005413 to 6.8824, and the Rec% values are observed within the range of 97.4719 to 104.487.
Anti‐Electromagnetic Radiation of Carbon Nanotubes Decorated PbO: Synthesis and Characterization
Authors: Askar Fatima Haider , Al‐Sumaidaie Ghazwan Hassan Abdel Wahab , Al‐Saadi Hoda Ali 
Published: February 2025

AbstractIn this study, carbon nanotubes are functionalized with lead salt to prepare a nanocomposite of carbon nanotubes with lead oxide via a heat treatment process at 900 °C. The composite is characterized using infrared spectroscopy, atomic force microscopy, scanning electron microscopy, and X‐ray diffraction. The results confirmed the presence of carbon nanotubes coated with lead oxide, indicating the success of the preparation method. The prepared composite is used in gamma ray shielding applications using brain membrane as a carrier surface for the carbon nanotube–lead oxide composite. The results showed that the composite is capable of blocking approximately 44% of the radiation using a quarter gram of carbon nanotubes doped with 0.0125 grams of lead oxide.
METTL1 Enhances RRP9 mRNA Stability Through m7G Modification to Drive Colorectal Tumorigenesis
Authors: Li Nan , Jing Ying , Xu Long , Wang Maonan 
Published: February 2025

ABSTRACTMETTL1, a well‐established RNA methyltransferase for the N(7)‐methylguanosine (m7G) methylation modification, is responsible for human tumorigenesis. Here, we aimed to examine the activity and molecular determinants of METTL1 in colorectal cancer (CRC) development. METTL1 and ribosomal RNA processing 9 (RRP9) mRNA analysis was performed by quantitative PCR. Protein expression was detected by immunoblotting and immunohistochemistry (IHC). Cell sphere formation, invasion, and proliferation were assessed by sphere formation, transwell, and MTT assays, respectively. Cell migration was tested by transwell and wound healing assays. Subcutaneous xenografts were produced to analyze the role in vivo. The influence of METTL1 in m7G methylation and stability of RRP9 mRNA was evaluated by methylated immunoprecipitation (MeRIP) assay and Actinomycin D (Act D) treatment, respectively. METTL1 was highly expressed in CRC tumors and cell lines. METTL1 depletion suppressed CRC cell proliferation, invasiveness, migratory ability, and sphere formation potential in vitro, while increased METTL1 expression had opposite effects. METTL1 positively correlated with RRP9 expression in CRC. Mechanistically, METTL1 promoted RRP9 mRNA stability by mediating its m7G methylation, and METTL1 regulated the PI3K/AKT signaling by RRP9. Increased RRP9 expression partially reversed the suppressive effects of METTL1 depletion on CRC cell phenotypes in vitro. METTL1 depletion impeded the growth of HCT‐116 subcutaneous xenografts in vivo by RRP9. Our observations identified METTL1 as a crucial protumorigenic factor to drive growth, metastasis, and stemness of CRC cells through RRP9, offering new targets for combating CRC.
Cross‐Cultural Adaption and Psychometric Evaluation of Chinese Version of the Caregiver Contribution to Self‐Care of Heart Failure Index
Authors: Miao Yanfei , Zhang Qing , Huang Hongmin , She Fei , Wang Bingjian , Mao Yiping 
Published: February 2025

ABSTRACTTo translate and adapt the English version of the Caregiver Contributions to Self‐Care of Heart Failure Index (CC‐SCHFI) to Chinese, and further to investigate the psychometric properties of the Chinese version of CC‐SCHFI in a cohort of caregivers of people with heart failure. CC‐SCHFI translation and cross‐cultural adaption were performed. 240 caregivers were recruited to complete the instrument. The internal construct reliability was evaluated by Cronbach's α and item‐to‐total correlations. The concurrent validity was tested by using the CACHS which also measures caregivers' contribution to HF self‐care. Psychometric analysis was performed with confirmatory factor analysis (CFA). We evaluated 4‐factor structure for caregiver contribution to self‐care maintenance scale, 1‐factor structure for caregiver contribution to self‐care management scale and 2‐factor structure for confidence in contributing to self‐care scale. All the subjects successfully completed the interviews in an average of 12.3 ± 3.2 min. The internal consistency reliability analysis of the CC‐SCHFI showed Cronbach α of 0.83. All items showed adequate discrimination, with the item‐total correlation coefficient of greater than 0.4. The scores of CC‐SCHFI scales were significantly correlated with the CACHS scale scores. The correlation coefficients ranged from 0.341 to 0.765, indicating acceptable concurrent validity. For CFA, all factor loadings were significant at > 0.30 and generally medium to high. The simplified Chinese version of CC‐SCHFI is a psychometrically reliable instrument with empirically supported validity, which can be applied to clinical evaluation of the contribution of caregivers to HF self‐care. Compared with CACHS, CC‐SCHFI can be more easily completed and simultaneously maintains acceptable concurrent validity. Further studies are warranted to investigate the combined use of these two instruments among other populations.
Molecularly Imprinted Nanoparticle‐Embedded Electrospun Mat as an Antibacterial Wound Dressing
Authors: Çerçi Azize , Akgün Oğuzhan , Karaca Esra , Bakhshpour‐Yücel Monireh , Arı Ferda , Yiğit Çınar Aycan , Bozkurt Güzel Çağla , Osman Bilgen 
Published: February 2025

ABSTRACTMolecularly imprinted polymer (MIP) nanoparticles offer a promising controlled drug delivery platform. In this study, amoxicillin (AMOX)‐imprinted polymer nanoparticles (~60 nm) were synthesized via emulsion polymerization and incorporated into polyvinyl alcohol (PVA)/sodium alginate (SA) [PVS] electrospun nanofibers to develop a novel wound dressing. The nanoparticle‐embedded PVS nanofibers (PVS‐AMOX‐MIP) demonstrated a sustained cumulative drug release of 43.6% over 2 days, governed by non‐Fickian transport per the Korsmeyer–Peppas kinetic model. The nanofibers exhibited favorable physical properties, including a high specific surface area (39.66 m2/g), optimal porosity (78.8%), and a water vapor transmission rate (1053.4 ± 5.9 g/m2/day), ideal for wound healing. Antibacterial activity studies showed significant inhibition against Staphylococcus aureus and Escherichia coli, while biocompatibility assays confirmed the mat's noncytotoxic nature and ability to promote cell proliferation. Furthermore, angiogenesis studies revealed enhanced vascularization, which is critical for tissue regeneration. The developed strategy offers a unique approach for advanced wound care and controlled drug delivery applications by combining MIP nanoparticles' molecular recognition capability with the structural advantages of electrospun nanofibers.
Exploring the Antifungal and Phytotoxic Activity of Polyvinyl Alcohol Hydrogels Incorporated With Essential Oils
Authors: de Castro Dione Pereira , dos Santos Carlos Diego Ribeiro , Sant'Ana Josué , Jacques Rosângela Assis , dos Santos Polidoro Allan , da Silva Silvia Helena Fuentes , Gatto Darci Alberto , Santana Ruth Marlene Campomanes 
Published: February 2025

ABSTRACTAgriculture is an important sector of the economy but consumes significant amounts of water, a precious and limited natural resource. However, superabsorbent polymers combined with essential oils (EO) can be used to obtain sustained release of nutrients and improved soil water retention capacity by hydrogel, and they act as a repellence in the crops of the natural farm crop enemies. Were synthesized, poly(vinyl alcohol) (PVOH) hydrogels, with crosslinked organics acids (malic and tartaric) and EO incorporated (clove, orange, and vanilla), is a novel method to develop release control of compounds with specific applications and show their potential agricultural and aphicide applications. The results show the incorporation of EO in the PVOH hydrogels, using a sonication process seen in the FTIR and optical microscopy analysis, obtaining good performance compared to traditional surfactants. In the olfactometer bioassay, the hydrogels show a repellent effect on Myzus persicae, under the synthesis time and EO specifically used, with a promising result for tartaric acid‐based hydrogels composed of Citrus chemical compounds except vanilla EO. To reduce germination and ecotoxicity, hydrogels decrease the germination and growth of plants, especially vanilla EO, showing inhibitory effects on onion and lettuce. All EO inhibited the mycelial growth of Aspergillus fumigatus, especially the samples with 2 h of the reaction. The hydrogels incorporated with clove, orange, and vanilla EO could be a promising alternative to natural agents to repel crop enemies' and provide antimicrobial and antifungal activity in agricultural systems.
Brush‐like nanostructured graphene oxide‐enabled interface engineering for enhancing mechanical properties of glass fiber/epoxy laminated composites
Authors: Zha Daoxin , Liu Yixiu , Han Luyao , Fang Chaoliang , Wu Qin , Jiang Xiaobin , Yu Congcong , Yu Manman , Zeng Shaohua , Chen Pengpeng 
Published: February 2025

AbstractGraphene oxide (GO) is preferred for addressing the issue of interfacial debonding in fiber‐reinforced composites. Herein, a brush‐like nanostructured GO was fabricated by grafting aliphatic diamine onto the basal plane of GO nanosheets through an amine‐epoxy ring‐opening reaction, and this brush‐like nanostructured GO was subsequently coated on the surface of glass fibers. The unique brush‐like nanostructure and the appropriate size of the functionalized GO nanosheets offer both steric hindrance and electrostatic repulsion, thereby achieving the well‐dispersed GO on the fiber surface. Due to the synergistic effects of physical and chemical interactions, the composites' interfacial adhesion between fiber and matrix could be prominently enhanced. When 1,8‐octanediamine‐functionalized GO with a suitable size of 1.0–5.0 μm was incorporated, both mechanical properties and thermal stability of laminated composites were at their best, compared with pure composite. This study provides an efficient interface engineering method for the production of high‐performance fiber reinforced composites.Highlights
A brush‐like nanostructure consisting of GO and aliphatic diamine is gained.
Well‐dispersed GO on the fiber surface is achieved.
Synergistic effect of physical and chemical interactions reinforces interface.
Functionalized GO with a suitable size (1.0–5.0 μm) helps reinforce interface.
Suitable GO restricts epoxy chains' mobility in glassy and rubbery regions.
Path‐following roller compaction for enhanced mechanical strength of short carbon fiber reinforced nylon in 3D printing
Authors: Chen Yiwen , Dai Ning , Bai Qingyun , Xiong Dajiang , Zuo Yuanzheng , Cheng Xiaosheng 
Published: February 2025

AbstractMaterial extrusion 3D printing often suffers from voids and poor interlayer bonding, which significantly weaken the mechanical properties of the printed parts. To address these issues, this paper proposes a path‐following roller compaction method aimed at reducing voids and improving interlayer bonding in short carbon fiber reinforced nylon parts. A mathematical model is developed to explain how roller compaction enhances interlayer bonding strength and reduces porosity, with quantifiable improvements. A dual‐roller system is designed to dynamically adjust to varying printing paths, ensuring effective layer compaction and compensating for layer height changes induced by roller pressure. Tensile and three‐point bending tests were performed to evaluate the impact of roller compaction depth on mechanical properties. Results show that maximum tensile strength improved by 141.2%, tensile modulus by 82.8%, bending strength by 62.4%, and bending modulus by 97.6%. This innovative method provides a significant enhancement in the performance and reliability of large‐scale, high‐performance rapid 3D printing applications.Highlights
Establish a porosity suppression model based on roller compaction.
Propose a nonlinear path‐following roller compaction method.
The mechanical properties of the structure were significantly improved after roller compaction.
Impact resistance and damage tolerance of resin‐infused thermoplastic noncrimp e‐glass fabric composites under marine environment
Authors: Hussnain S. M. , Shah S. Z. H. , Megat‐Yusoff P. S. M. , Hussain M. Z. 
Published: February 2025

AbstractThis article presents the effect of seawater aging on the impact response and damage tolerance of resin‐infused thermoplastic fiber‐reinforced composites (FRCs). The thermoplastic composites were immersed in seawater at two different aging conditions (i.e., 35 and 70°C) until their saturation state. The aged and unaged samples were tested under low‐velocity impact (LVI) at three impact energies (30, 60, and 90 J), followed by the compression after impact (CAI) test to evaluate the degradation in the damage tolerance. The LVI test revealed that increasing the moisture content, the peak force and displacement increased up to 28% and 31%, respectively, indicating higher load‐bearing capacity of thermoplastic composites under aged conditions. This increase in peak force and displacement of FRCs is attributed to the plasticization effect in the thermoplastic matrix due to the hygrothermal environment. Furthermore, the unaged samples showed barely visible impact damage at lower impact energy, while under aged conditions, fiber–matrix interface debonding, fiber breakage, and fiber pullout are the prominent failure mechanisms. The CAI response of thermoplastic composites exhibits up to 45% increase in compressive strength with increasing moisture content. This increase in damage tolerance is attributed to matrix plasticization and swelling caused by hygrothermal aging. The superior impact performance and damage tolerance of thermoplastic composites in hygrothermal conditions indicate their suitability for applications requiring higher bearing strength.Highlights
Effect of accelerated aging on impact resistance and damage tolerance of FRC.
An increase in moisture content leads to an increase in peak force up to 28%.
Hygrothermal aging increases the CAI strength by up to 45%.
Plasticization and matrix swelling are dominant damage modes in NCF composite.
A point mutation in IAA34 confers resistance to the auxin herbicide 2,4‐D in Sisymbrium orientale
Authors: Qi Yuanlin , Krishnan Mahima , Tucker Matthew , Preston Christopher 
Published: February 2025

AbstractBACKGROUNDSisymbrium orientale has evolved resistance to 2,4‐D in Australia due to a 27 bp deletion in SoIAA2. However, one population of Sisymbrium orientale resistant to 2,4‐D (R1) did not contain the SoIAA2Δ27, suggesting another 2,4‐D resistance mechanism was present in this population. Here, we reported a novel target‐site resistance mechanism of 2,4‐D in the R1 population.RESULTSR1 is resistant to 2,4‐D, 2‐methyl‐4‐chlorophenoxyacetic acid (MCPA), and fluroxypyr with increased tolerance to dicamba, triclopyr and picloram. The 2,4‐D resistance level for R1 is lower than resistant populations containing a 27 bp deletion in IAA2. 2,4‐D resistance in R1 was due to a single dominant gene. Pretreatment of R1 with the P450 inhibitor malathion did not reduce resistance to 2,4‐D. We identified a point mutation, Leu 175 Pro, in SoIAA34 in R1, but not in three susceptible (S) populations. This mutation was present (either homozygous or heterozygous) in all 2,4‐D resistant plants in a segregating F2 population generated from a cross between S and R1 plants. Transgenic Arabidopsis plants expressing SoIAA34‐R had significantly greater root length and dry mass than the wild‐type (WT) or transgenic Arabidopsis plants carrying SoIAA34‐S under 2,4‐D treatment.CONCLUSIONWe confirmed resistance to 2,4‐D in the R1 population was controlled by a single dominant locus. Further, we verified that the Leu 175 Pro mutation in SoIAA34 is responsible for the 2,4‐D resistance in R1. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.