bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hipertansif kişilerin hipertansiyon konusundaki tutum ve davranışları
Authors: ERGÜN ARSLANTAŞ Ebru , SEVİNÇ Nergiz , ÇETİNKAYA Fevziye , GÜNAY Osman , AYKUT Mualla 
Published: December 2019

Amaç: Hipertansiyon tüm dünyada sık görülen bir hastalıktır ve hipertansif hastalarda farkındalık oranı düşüktür. Bu nedenle hastaların sağlığını etkileyen uygun davranışları kontrol etmesi gerekmektedir. İdeal vücut ağırlığı, hareketli yaşam, tuz ve doymuş yağlardan fakir diyetle beslenme, sigara ve alkol kullanmama ve stresten uzak durma önerilmektedir. Bu araştırma hipertansiyon tanısı almış erişkin kişilerin hastalıklarının kontrolü ile ilgili tutum ve davranışları ile bunları etkileyen faktörleri belirlemek amacıyla yapılmıştır.
Gereç ve Yöntem: Bu kesitsel araştırma Kayseri ili Kocasinan, Melikgazi, Talas ve Hacılar ilçelerine bağlı 4 ayrı Aile Sağlığı Merkezi‟nde yürütülmüştür. Daha önce hipertansiyon tanısı almış ve aile sağlığı merkezlerine herhangi bir nedenle başvuranlardan araştırmaya katılmayı kabul eden, 18 yaş ve üzeri 525 kişi araştırma kapsamına alınmıştır. Veri toplama aracı olarak, hastaların sosyodemografik özellikleri ve hipertansiyonla ilgili tutum ve davranışları ile ilgili 37 sorudan oluşan anket formu kullanılmıştır. Verilerin analizinde Pearson Ki-Kare testi kullanılmıştır.
Bulgular: Araştırma grubunda, düzenli ilaç kullandığını belirtenlerin oranı %80,8, düzenli doktor kontrolü yaptıranların oranı %62,9 bulunmuştur. Katılımcıların %27,6‟sı sigara, %9,3‟ü alkol kullanmaktadır, %36,8‟i tansiyonları yükseldiğinde hekime başvurduğunu, % 63,2‟si tansiyonu düşürdüğüne inandığı yiyecek ve içecek aldığını belirtmişlerdir. Araştırmaya katılanların % 41,1‟i düzenli fiziksel aktivite yapmakta olup, %70,5‟i yemeklerinde tuz kısıtlaması yapmaktadır. BKI değerlerine göre, erkeklerin %7,0„si kadınların %16,1‟i obez olarak değerlendirilmiştir.
Sonuç: Araştırma grubunda, hipertansiyon farkındalığı istenilen düzeyde değildir. Hastaların hipertansiyondan korunma önlemleri hakkında tutum ve davranışlarının yetersiz olduğu belirlenmiştir. Hipertansiyon hastalarının tedaviye uyumunu sağlamak için hipertansiyon konusunda bilgilendirilmesi, düzenli doktor kontrolü ve ilaç kullanımı konusunda yönlendirilmesi, evde kan basıncı ölçümünün öğretilmesi gerekir.
Sex Differences of the Brain Structural Adaptation to Hypoxic Environment
Authors: Fan Cunxiu , Zhao Cunhua , Zhao Yuhua , Yin Wu , Lin Jianzhong , Zhang Jiaxing 
Published: December 2019

Abstract
Background: Different physiological and pathological patterns have been found in the two sexes at high altitude. However, sex differences in brains remain unknown.
Methods: T1-weighted MRI scanned in 61 Tibetan males and 68 Tibetan females aged 17-23, and Freesurfer was used to detect brain structures. Neuropsychological tests were also performed. Matched lowland Han subjects were controls.
Results: Both Tibetan and Han males had larger global gray matter (GM) volume and white matter volume than females, while Tibetan but not Han female brains contained a larger proportion of GM than male brains. Tibetan females had significant smaller regional GM volume in the left rostral middle frontal gyrus, pars opercularis, and right caudal middle frontal gyrus, and moreover, GM volume in the left pars opercularis positively correlated with digit span score. However, Tibetans females had significantly thicker cortices in the left rostral middle frontal gyrus, left pars triangularis, right rostral middle frontal gyrus, and right pars triangularis than males and cortical thickness in these regions negatively correlated with altitude. In Tibetan females but not males, the negative correlation of cortical thickness with altitude has been testified by global analysis. Conversely, Han subjects showed discrepant sex differences in brains with Tibetans, showing larger regional GM volume and thicker cortices in different brain areas.
Conclusion: A distinct pattern of sex differences exists between Tibetan and Han brains. Female brains may be more tolerable to hypoxia. Sex differences in the brains of Tibetans may be related to different neuropsychiatric performances in the two sexes.
Prevalence and associated factors of cervical cancer among women in Ethiopia: A systematic review and meta-analysis
Authors: Asrat Dereje Zena , Feleke Berhanu Elfu , Mihretie Kebadnew Mulatu 
Published: December 2019

Abstract
Background: cervical cancer is the second commonest disease of women in Ethiopia. Even though, some studies were conducted to assess the prevalence and associated factors of cervical cancer among women in Ethiopia, a variation in reported prevalence across the studies were observed. The aim of this study was to determine the pooled prevalence estimate and associated factors of cervical cancer among women in Ethiopia. Methodology: A systematic review and meta-analysis was performed based on published and gray literatures between 2010 and 2019. Articles were evaluated using Joanna Briggs Institute database guidelines by two independent authors. The pooled prevalence estimate was calculated using MedCalc software-version 19.0.7 and the pooled odd ratios for predictors was calculated using RevMan software version 5.3. A meta-analysis using a mantel Hansen variance random-effects model was performed to assess the amount of variation in between studies. The report was depicted descriptively using pooled estimated prevalence and odd ratios using tables and plots. Result: From 124 retrieved data, 10 full text articles were eligible for the review. The pooled prevalence estimates of cervical cancer among women in Ethiopia using random-effect model was 15.7%, 95%CI (10.8, 21.3%). Statistically significant heterogeneity between studies was detected (I 2 =94.35% (p<0.0001). Among all associated factors measured: numbers of life time sexual partners >1, OR=0.40, 95% Cl (0.21,0.27), being HIV positive, OR=0.41,95%CI(0.21,0.75), having history of STI,OR=1.99,95% CI (1.02,3.87), women getting widowed, separated or divorced), OR=0.32, 95% CI(0.14,0.75),income <1000birr, OR=1.78, 95% CI (1.19,2.65) and women had experience of contraceptive use, OR=2.32, 95% CI (1.75,3.43) were had statistical significant association with cervical cancer among women in Ethiopia Conclusion: The pooled prevalence estimate of cervical cancer among women in Ethiopia was high. There was a variation of cervical cancer reports across studies. Reporting of this information in a consistent manner is important for researchers to enhance future studies and also useful for policymakers and practitioners for better understanding of the burden of cervical cancer in Ethiopia for prevention, diagnosis, and early treatment of the disease. Trial registration: This systematic review for registration in PROSPERO was retrospectively registered on June 20,2019.
Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient – last-chance antibiotics and phage therapy
Authors: Rostkowska Olga Maria , Międzybrodzki Ryszard , Miszewska-Szyszkowska Dorota , Górski Andrzej , Durlik Magdalena 
Published: December 2019

Abstract
Background: The article underlines the problem of antimicrobial resistance in transplant departments where wide-spectrum antibiotics must often be used as first line treatment for immunocompromised patients. This applies especially to kidney transplant recipients who suffer from urinary tract infections. Additional means to control infections and support treatment methods are much needed in departments treating transplant patients. Case presentation: This article presents a case of a 60-year-old patient after kidney transplantation repeatedly admitted to the hospital due to recurrent urinary tract infections, including an episode of urosepsis, caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBL). Kidney transplantation was performed due to renal insufficiency caused by polycystic kidney disease, without removing of the patient’s own kidneys. As a consequence of numerous episodes of urinary tract infections (12 episodes within 15 months since transplantation), the patient developed chronic infection caused by ESBL-producing K. pneumoniae which showed variable susceptibility to carbapenems and full susceptibility to colistin only. In the meantime, the patient developed accompanying urinary tract infection caused by a vancomycin-resistant Enterococcus faecium and subsequent colonisation of the gastro-intestinal tract by this strain. In an attempt to curb the K. pneumoniae infection, bacteriophage therapy was applied on the experimental basis, coordinated by the Phage Therapy Unit of the Hirszfeld Institute in Wrocław, Poland. Probiotics were also used in an attempt to modify the bacterial gut colonisation. Eventually, the patient fully recovered following nephrectomy of his own left kidney in which cysts were suspected to be the reservoir of bacteria causing recurring infections. In this article we discuss some treatment methods complementary to classic antibiotic therapy, in times when antimicrobial resistance is on the rapid rise. Conclusions: It is necessary to further research methods of decreasing our reliance on antibiotics in view of falling susceptibility to those medicines. Phage therapy or altering patient’s microbiome can give us an edge in tackling infections which today are treated solely with antimicrobials. This would be of great significance to transplant departments.
Arsenic removal by the micellar-enhanced ultrafiltration using response surface methodology
Authors: Gokcek Oznur Begum , Uzal Nigmet 
Published: December 2019

Abstract
The present research investigates the removal of arsenic (As) from aqueous solutions using micellar-enhanced ultrafiltration (MEUF) by utilizing two different surfactants: benzethonium chloride and dodecyl pyridinium chloride (BCl and DPCl). The impact of the operating variables and maximum removal efficiency were found under different conditions for BCl and DPCl surfactants. The maximum As rejection efficiency for MEUF with BCl and DPCl surfactants is 92.8% and 84.1%, respectively. In addition to this, a statistics-based experimental design with response surface methodology was used for the purpose of examining the impact of operating conditions, including initial pH, initial As concentration (ppb), and surfactant concentration (BCl, mM) in As-removal from aqueous solutions. In the analysis of the experimental data, a second-order polynomial model that was validated by statistical analysis for the BCl surfactant was used. On the basis of the response model created, the removal of As ions was acquired at optimum operating parameters, including the initial As concentration of 150 ppb, surfactant concentration of 5 mM and pH 10 for the BCl surfactant with 92.8% As-removal efficiency.
Integrated surface and groundwater resources allocation simulation to evaluate effective factors on greenhouse gases production
Authors: Majedi Hamidreza , Fathian Hossein , Nikbakht-Shahbazi Alireza , Zohrabi Narges 
Published: December 2019

Abstract
The water resources management in the developing countries calls for the adoption of the systems approach in accordance with the regulations of the Kyoto Protocol (1997) clean development mechanism. In this research, integrated modeling was carried out under multipurpose scenarios using six reservoir dams with a capacity of 10,500 MW (megawatt) to reduce the greenhouse gas productions. The simulation and development of the integrated water evaluation and planning (WEAP) model within a 50-year period, along with the development of the MODFLOW model in alluvial deposits that interacts with the river, allowed for the analysis of the integrated water resources management system of the Great Karun basin. Several scenarios were implemented following the calibration and validation of the linked integrated model. The components covered by these scenarios included the satisfaction of the in-basin and off-basin demands, the effect of the integrated consumption of water resources, and the effect of increased efficiency of irrigation networks with maximum clean hydroelectricity production and minimum aquifer level decline under drought-induced water shortage conditions. The second scenario, which generates 15,282 GWh (gigawatt-hour) of power, not only optimally meets the future and environmental demands as the best operating scenario but also minimizes the emission of the greenhouse gases in the basin.
Computational Models for Self-Interacting Proteins Prediction
Authors: Qu Jia , Zhao Yan , Zhang Li , Cai Shu-Bin , Ming Zhong , Wang Chun-Chun 
Published: December 2019

:
Self-Interacting Proteins (SIPs), whose two or more copies can interact with each other,
have significant roles in cellular functions and evolution of Protein Interaction Networks (PINs).
Knowing whether a protein can act on itself is important to understand its functions. Previous
studies on SIPs have focused on their structures and functions, while their whole properties are less
emphasized. Not surprisingly, identifying SIPs is one of the most important works in biomedical
research, which will help to understanding the function and mechanism of proteins. It is worth
noting that high throughput methods can be used for SIPs prediction, but can be costly, time
consuming and challenging. Therefore, it is urgent to design computational models for the
identification of SIPs. In this review, the concept and function of SIPs were introduced in detail.
We further introduced SIPs data and some excellent computational models that have been designed
for SIPs prediction. Specially, the most existing approaches were developed based on machine
learning through carrying out different extract feature methods. Finally, we discussed several
difficult problems in developing computational models for SIPs prediction.
Deciphering the Novel Target Genes Involved in the Epigenetics of Hepatocellular Carcinoma Using Graph Theory Approach
Authors: Roy Nimisha , Raj Utkarsh , Rai Sneha , Varadwaj Pritish K. 
Published: December 2019

Background:
Even after decades of research, cancer, by and large, remains a challenge and is
one of the major causes of death worldwide. For a very long time, it was believed that cancer is simply an
outcome of changes at the genetic level but today, it has become a well-established fact that both genetics
and epigenetics work together resulting in the transformation of normal cells to cancerous cells.

Objective:
In the present scenario, researchers are focusing on targeting epigenetic machinery. The
main advantage of targeting epigenetic mechanisms is their reversibility. Thus, cells can be reprogrammed
to their normal state. Graph theory is a powerful gift of mathematics which allows us to understand
complex networks.

Methodology:
In this study, graph theory was utilized for quantitative analysis of the epigenetic network
of hepato-cellular carcinoma (HCC) and subsequently finding out the important vertices in the
network thus obtained. Secondly, this network was utilized to locate novel targets for hepato-cellular
carcinoma epigenetic therapy.

Results:
The vertices represent the genes involved in the epigenetic mechanism of HCC. Topological
parameters like clustering coefficient, eccentricity, degree, etc. have been evaluated for the assessment
of the essentiality of the node in the epigenetic network.

Conclusion:
The top ten novel epigenetic target genes involved in HCC reported in this study are
cdk6, cdk4, cdkn2a, smad7, smad3, ccnd1, e2f1, sf3b1, ctnnb1, and tgfb1.
Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review
Authors: Kriplani Priyanka , Guarve Kumar , Baghel Uttam S. 
Published: December 2019

Objective:
Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat
various medical conditions. Though many plants are proving their effectiveness but their mechanisms
are still not well understood. The objective of the review is to summarize various mechanisms of helenalin
to treat inflammatory disorders and cancers, adverse effects, and avenues of further research.

Methods:
Structured research was carried out including Pub med, Science direct Medline, Research
Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”,
“Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The
aim of the review was to find out the problem prevailing in the data published to date which will help
the researchers to investigate the molecule clinically.

Results:
Seventy articles are included in the review. Helenalin is found to cure chronic conditions like
rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers
via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful
molecule to treat numerous diseases.

Conclusion:
This review article will help us to systemically analyze the wealth of information concerning
the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application
in the medical community.
Analysis Of Vegetation Classification Algorithms On Satellite Images And Medical Images
Authors: Manju S. , Helenprabha K  
Published: December 2019

:
In recent days, the remote sensing algorithms are used in the medical field for improving the visualization of the medical images. Because, the medical images are generally in the gray scale image format for better visualization the colour Doppler or spectrograms are used but they are expensive. To overcome this drawback the remote sensing algorithm is applied to the medical images to group the pixels and visualize in different colours. The image processing techniques is used to classify the vegetation region into 16 samples. The image pre-processing is done by Wiener filter to remove the noise. Feature extraction is carried out by Grey Level Co-occurrence Matrix (GLCM) and the spectral bands are optimized by Particle Swarm Optimization (PSO) .The classification of vegetation region is classified by Extreme Learning Machine. In this, the comparisons of the remote sensing algorithms like IRVM-MFO, ELM-DF and ELM-PSO for the Indian pines and Salinas Dataset. Among these the ELM- Dragon Fly algorithm produced the best results for both the sets. Hence, this ELM-DF is applied to the Brain tissue region segmentation. In this paper the analysis is performed to find the efficient method for vegetation classification by comparing with other methods. Simulations are carried out on two datasets such as Indian Pine and Salinas scene. Performance metrics such as accuracy, specificity, and sensitivity have been evaluated that show the efficiency of the proposed classifier.
Primary Hypothyroidism in Adults Based on Jorjani's View Point of the Book “Zakhire Kharazmshahi”
Authors: Ebrahimpour Naser , Khazaneha Mahdieyh , Tajadini Haleh 
Published: December 2019

Objective:
The prevalence of primary hypothyroidism is increasing in adults (PHTA), and the reduction in the threshold for treatment and also the requirement to increase drug usage are major problems in approaching this disorder. Persian Medicine (PM) looks from a different view on etiology of diseases. Therefore, we tried to present the etiologies of PHTA according to an important book of PM i.e. “Zakhire Kharazmshahi”.

Method:
At first, the common symptoms and signs of PHTA were identified by investigating the Medline, Scopus, and Cochrane databases and their Persian equivalents were extracted from PM sources. These synonyms were searched as keywords in the book and the primary causes that were mentioned in association with the signs and symptoms were extracted. Then, we explained the total etiologies that were discussed for the occurrence of the causes, with respect to the principles of health care in PM.

Results:
"Cold distemperament", an increase in "Phlegmatic Humor ", an increase in "Melancholic Humor" and "Emtela" (repletion) were recognized as four main causes of PHTA. According to the book, the most important etiologies of these conditions are insufficient exercise, overeating, food intake before total stomach emptying and excessive amounts of cold temperament substances (foods, herbs, seeds, spices, etc.) in daily diet.

Conclusion:
From the viewpoint of PM, lifestyle spatially eating habits and physical activity play important causative roles in occurring and prognosis of PHTA. Hence, it is recommended to assess these results by more observations and clinical studies.
Análisis teórico de los mitos financieros del emprendimiento
Authors: Socorro Márquez Félix Oscar , Santa Álvarez Gloria Liliana 
Published: December 2019

Luego de revisar literatura relacionada, fue posible documentar cinco mitos financieros asociados con el emprendimiento, esto se hizo tomando en cuenta la postura de varios autores expertos en estos temas y otras fuentes de información disponibles, lo que permitió, bajo una visión académica y crítica, aportar un contenido de interés para quienes desean hacer uso de esta herramienta y consideran que poseen debilidades conceptuales o carecen de información vital para garantizar la salud financiera de su emprendimiento.
El marketing olfativo como posicionamiento de marcas
Authors: Grisales Castro Claudia Patricia 
Published: December 2019

El objetivo de este estudio se basa en analizar la percepción que tienen los consumidores sobre el marketing sensorial olfativo, como estrategia utilizada para el posicionamiento de las marcas.
El sentido del olfato siempre ha sido un factor determinante en la toma de decisiones del ser humano, sin embargo, los estudios que existen sobre el proceso que vincula los aromas, el olfato y las marcas. Son descriptivos y de carácter interno por esta razón no pueden confirmar que un aroma estratégico, aplicado a una empresa o marca sea un factor de posicionamiento efectivo.
Algunas marcas ya utilizan el sentido del olfato como activador de relaciones, emociones y sentimientos con sus clientes, aprovechando que sentido del olfato no presenta saturación publicitaria, y tiene comunicación directa con la memoria, sin embargo, es una estrategia aislada que migra de otros países y que para la mayoría de empresas es un concepto nuevo como aplicación de marketing sensorial.
Se realizó una investigación cuantitativa de tipo exploratoria utilizando encuestas aplicadas a (120) consumidores, entre hombre y mujeres en edades 18 a 60 años con procesos de compra y consumo en el territorio colombiano.
Los hallazgos relacionan positivamente al consumidor y los aromas, también se puede evidenciar lo novedoso que es para el mercado el concepto de marketing olfativo, confirmando que algunos consumidores si conocen este tipo de estrategias, y la han experimentado en grandes marcas, como hoteles, restaurantes y sector vestuario.
Como conclusiones se puede evidenciar una disposición por parte de los consumidores en la implementación de estrategias sensoriales olfativas para las marcas. Convirtiéndose esto en una oportunidad de mercado interesante para las empresas, desarrolladoras y distribuidoras de marketing olfativo, ya que el consumidor en general está dispuesto a disfrutar de la estrategia sensorial olfativa.