bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude and practices related to COVID-19 among young Lebanese population
Authors: Sakr Samer , Ghaddar Ali , Sheet Imtithal , Hamam Bassam 
Published: September 2020

Abstract
Background: As the world faces the most serious and widespread pandemic in recent history, claiming nearly 700,000 lives and infecting close to 17 million individuals, controlling the spread of COVID-19 is still limited to efforts done by the general population implementing rules and restrictions passed by world governments and organizations. Awaiting the development of a cure or a vaccine, the best approach to fighting the spread of this disease is mostly preventative depending largely on individuals’ compliance. This study aims to test the KAP towards COVID-19 in Lebanon. Methods: A cross-sectional study of Lebanese population comprising of 1861 participants was used to analyze the knowledge, attitude and practices of individuals concerning COVID-19 in relationship to multiple variables such as age, gender, marital status, living area, education level, occupation in addition to their degree of worrying about this disease. Results: Our participants showed an overall appropriate knowledge (67.1%), positive attitude and practices that ranged from fair to very good, depending on its type, regarding COVID-19. When the components of KAP were analyzed with respect to variables, we found that levels of knowledge and practices positively correlated with people who were ever married, older, with higher degrees, worked in a healthcare field and with the degree of worry about getting COVID-19. Conclusions: In the absence of a vaccine, pandemics such as the current COVID-19 are best combatted by increasing public awareness leading to collective preventative practices. A key factor in this effort lies in creating a good environment that enhances people’s compliance with considerate pandemic behavioral rules in which governing bodies must be pivotal.
Sleep quality and mental health of medical workers during the coronavirus disease 2019 pandemic
Authors: Zheng Yahua , Wang Lili , Feng Lingfei , Ye Lingxiao , Zhang Aiping , Fan Rui 
Published: September 2020

Abstract
Purpose To assess the sleep quality, mental health status and associated factors among medical workers during the coronavirus disease 2019 (COVID-19) pandemic. Methods A cross-sectional study was conducted and medical workers in Ningbo, China were recruited. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI). Mental health status was evaluated by Symptom Checklist 90(SCL-90). Logistic regression and generalized multi-factor dimensionality reduction (GMDR) analysis were utilized to explore the risk factors and their interactions on sleep quality and mental health status. Results 207 participants were surveyed, 34.3% were found with poor sleep quality (total PSQI score > 10), mainly manifested as sleep disturbance (92.8%). 27.05% were found with mental symptoms (Global severity index > 1.5), mainly manifested as obsessive-compulsive (25.6%). Multivariate logistic analysis showed male (OR = 3.886, 95%CI = 1.061-14.239, P = 0.040), working years >15 years (OR = 4.505, 95%CI = 1.561-12.998, P = 0.005), nurse (OR = 5.642, 95%CI = 1.347-23.632, P = 0.018), more night shifts (OR = 3.098, 95%CI = 1.308-7.336, P = 0.010), supporting Wuhan (OR = 3.413, 95%CI = 1.120-10.395, P = 0.031) were associated with poor sleep quality. GMDR analysis showed there was a two-factor interaction between working years and working shifts (P = 0.0107). No significant factors and interactions were found associated with mental symptoms. Conclusions About one-third of medical workers suffered from sleep and mental problems during the COVID-19 pandemic in the current study. Interventions for sleep and mental problems among medical workers were needed based on related factors.
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities
Authors: Reddy Gangireddy Sujeevan , Pal Manojit 
Published: September 2020

Background:
The indole framework is considered as one of the privileged structures
in the area of medicinal chemistry and drug discovery because compounds containing
this framework have shown to possess a remarkable ability to bind with many receptors or
proteins with high affinity. It is therefore not surprising that the indole nucleus is a frequently
found moiety in many bioactive agents or drugs. Indole derivatives have also been explored
or studied for their anti-tubercular properties for a long time. The growth inhibition of Mycobacterium
tuberculosis (MTB) in vitro and in vivo by the gut microbiota metabolite indole
propionic acid (IPA) is one of the recent examples. Notably, tuberculosis (TB), an intractable
disease and a major cause of death worldwide, has caused an alarming rise in the number of
TB cases recently because of two main reasons, i.e., a several-fold rise among HIV-infected
patients and increased drug resistance by some bacterial strains. Thus, the identification of
new agents or potential drugs against TB is urgently needed.

Methods:
While the specific pharmacological target or mechanism of action (MOA) for antitubercular
activities has been reported for many indole derivatives, the MOA is not well defined
or known for a number of indole derivatives though they were found to be active
against MTB. In the current review article, we have focused on both types of indole derivatives
that have shown activities against MTB. The indoles with known MOA are further segregated
based on this pharmacological target reported or indicated whereas other indoles are
classified based on the type of anti-TB properties shown by them. The literature for the last
20 years as well as related to up to date knowledge and information was searched on Pubmed,
Google Scholar, MEDLINE, and various other databases until August 2020.

Results:
A diverse range of functionalized indole derivatives, such as indole-based alkaloids,
simple indoles, fused indoles, amide/peptide derivatives of indole, isatin derivatives, etc.,
have been reported to possess anti-tubercular activities. The anti-tubercular activities, in silico
studies (if reported) and the chemical syntheses (in most of the cases) of representative
indole derivatives are presented briefly in the current article. The papers referenced by this
review allow a deep analysis of the status of the indole-based anti-tubercular agents explored
over the past two decades.

Conclusion:
This review aims at stimulating renewed interest and effort in the discovery and
development of new indole-based agents or potential drugs for the treatment of TB. The
emergence of modern methods, especially those based on transition metal-catalyzed reactions,
has opened up tremendous opportunities in the area of indole synthesis. The desired
goal would be to have utilized these modern methodologies for the identification of potent
and promising agents to fight against MTB.
Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer
Authors: Desai Drashti , Shende Pravin 
Published: September 2020

:
Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and
treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active
immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy
is mAbs-based therapy effective against tumor cells, which acts by targeting HER2,
IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas
of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or
NPS receptor 1, acts as a biomarker for Neuroendocrine tumors (NET), mostly characterized by synaptophysin
and chromogranin-A expression or Ki-67 proliferation index. The protein fusion technologies
arise as a promising avenue in plant expression systems for increased recombinant Ab accumulation
and cost-efficient purification. Recently, mAbs-based immunotherapy effectiveness is
appreciated as a novel therapeutic combination of chemotherapy and immunotherapy to reduce the
side effects and improve therapeutic responsiveness. Synthetic drug resistance will be overcome by
mAbs-based therapy through several clinical trials and detection methods need to be optimized for
accuracy and precision. Pharmacokinetic attributes need to be accessed for preferred receptor-agonist
activity without ligand accumulation.
Identification of 3-Bromo-1-Ethyl-1H-Indole as a Potent Anticancer Agent with Promising Inhibitory Effects on GST Isozymes
Authors: Yılmaz Can , Arslan Sevki , Mutlu Dogukan , Konus Metin , Kayhan Abdussamet , Kurt-Kızıldoğan Aslıhan , Otur Çiğdem , Ozok Omruye , Kivrak Arif 
Published: September 2020

Background:
Indole based heterocyclic compounds plays important roles in pharmaceutical chemistry due to their unexpected
biological and pharmacological properties.

Objective:
Herein, we describe novel biological properties (antioxidant, antimicrobial and anticancer) of 3-bromo-1-ethyl-1H-indole
(BEI) structure.

Method:
BEI was synthesized from 1-Methyl-2-phenylindole and N-bromosuccinimide and were characterized by using 1H and 13C
NMR. 1H and 13C NMR. Cytotoxity was determined by MTT assay. Apoptosis analysis of BEI was determined by Arthur™ imagebased Cytometer. Different methods was applied to assessed the antioxidant activity of BEI. Molecular docking studies were conducted
to determine the interactions of bonding between GST isozymes and BEI.

Results:
According to the antioxidant and antimicrobial activity assays, BEI compound showed less total antioxidant activity compared
to trolox standard whereas it showed moderate antimicrobial activity against Aspergillus niger and Phytophora eryhtrospora. Notably,
BEI compound demonstrated substantial selective cytotoxicity for the first time towards cancer cell lines and there existed significant
decrease in the percentage of live cells treated with BEI, in comparison to the control ones. Interestingly, BEI exhibited a promising
glutathione S-transferase isozymes inhibition.

Conclusion:
The results of this study suggest that BEI seems to be a promising molecule to be used in design of new anticancer agents
that provide superiority to present commercial anticancer drugs.
COVID-19: Insights into Structure-Function Relationship, Drug Targets and Drug Design Strategies for Novel-Coronavirus 2019
Authors: Bhardwaj Snigdha , Singh Shaminder , Bhatia Sonam 
Published: September 2020

Background:
Novel coronavirus (2019-nCov) imposed deadly health calamity with unexpected
disastrous situation alarming the globe for urgent treatment regimes. World Health Organization
(WHO) termed the coronavirus disease as COVID-2019 on February 11, 2020 and announced its outbreak
as pandemic on 11 March 2020. The first infection was noticed in Wuhan, Hubei province, China,
in December 2019, and it is believed that the corona-virus is transmitted to humans through bats as a
reservoir involving human to human transfer. However, the proper intermediary transmission channel is
yet to be unestablished.

Methods:
Elderly populations and patients with concomitant symptoms are more at risk as compared to
middle-aged patients as it may progress to pneumonia followed by severe acute respiratory syndrome
(SARS) and multi-organ failure. Morbidity rates estimated in patients are less, i.e., 2-3%, but the dearth
of a specific treatment strategy to prevent coronavirus infection is a major concern.

Results:
Currently, anti-viral and anti-malarial drugs are in practice for the management of COVID-19
disease along with plasma therapy in the absence of a potent vaccine. Besides, home isolation and social
distancing are the precautionary measures adopted by many countries to minimize the spread of infection.
Various studies have been conducted, and numerous are still going on to establish specific treatment
for COVID-19.

Conclusion:
In this review, we summarized information on the structural components of COVID19 virus
with special emphasis on the virus genome, life cycle, the importance of protease enzyme, the role of
spike proteins in viral replication, validated drug targets, ongoing effective treatments for COVID-19
management and the latest research on drug design to develop anti-CoV drugs.
Social Media Listening to Understand the Lived Experience of Presbyopia: Systematic Search and Content Analysis Study
Authors: Wolffsohn James S , Leteneux-Pantais Claudia , Chiva-Razavi Sima , Bentley Sarah , Johnson Chloe , Findley Amy , Tolley Chloe , Arbuckle Rob , Kommineni Jyothi , Tyagi Nishith 
Published: September 2020

Background
Presbyopia is defined as the age-related deterioration of near vision over time which is experienced in over 80% of people aged 40 years or older. Individuals with presbyopia have difficulty with tasks that rely on near vision. It is not currently possible to stop or reverse the aging process that causes presbyopia; generally, it is corrected with glasses, contact lenses, surgery, or the use of a magnifying glass.

Objective
This study aimed to explore how individuals used social media to describe their experience of presbyopia with regard to the symptoms experienced and the impacts of presbyopia on their quality of life.

Methods
Social media sources including Twitter, forums, blogs, and news outlets were searched using a predefined search string relating to symptoms and impacts of presbyopia. The data that were downloaded, based on the keywords, underwent manual review to identify relevant data points. Relevant posts were further manually analyzed through a process of data tagging, categorization, and clustering. Key themes relating to symptoms, impacts, treatment, and lived experiences were identified.

Results
A total of 4456 social media posts related to presbyopia were identified between May 2017 and August 2017. Using a random sampling methodology, we selected 2229 (50.0%) posts for manual review, with 1470 (65.9%) of these 2229 posts identified as relevant to the study objectives. Twitter was the most commonly used channel for discussions on presbyopia compared to forums and blogs. The majority of relevant posts originated in Spain (559/1470, 38.0%) and the United States (426/1470, 29.0%). Of the relevant posts, 270/1470 (18.4%) were categorized as posts written by individuals who have presbyopia, of which 37 of the 270 posts (13.7%) discussed symptoms. On social media, individuals with presbyopia most frequently reported experiencing difficulty reading small print (24/37, 64.9%), difficulty focusing on near objects (15/37, 40.5%), eye strain (12/37, 32.4%), headaches (9/37, 24.3%), and blurred vision (8/37, 21.6%). 81 of the 270 posts (30.0%) discussed impacts of presbyopia—emotional burden (57/81, 70.4%), functional or daily living impacts (46/81, 56.8%), such as difficulty reading (46/81, 56.8%) and using electronic devices (21/81, 25.9%), and impacts on work (3/81, 3.7%).

Conclusions
Findings from this social media listening study provided insight into how people with presbyopia discuss their condition online and highlight the impact of presbyopia on individuals’ quality of life. The social media listening methodology can be used to generate insights into the lived experience of a condition, but it is recommended that this research be combined with prospective qualitative research for added rigor and for confirmation of the relevance of the findings.
Las rizobacterias halófilas mantienen la calidad forrajera de Moringa oleifera cultivada en sustrato salino
Authors: García Mendoza Verónica , Hernández Vázquez Alex Edray , Reyes Carrillo José Luis , Figueroa Viramontes Uriel , Sáenz Mata Jorge , Quiroga Garza Héctor Mario , Olivares Sáenz Emilio , Cano Ríos Pedro , García Martínez José Eduardo 
Published: September 2020

Para obtener un incremento en la producción forrajera de Moringa oleifera Lam. y de buena calidad se puede combinar el uso de compost a base de estiércol bovino y la inoculación de biofertilizantes a base de rizobacterias promotores del crecimiento vegetal (PGPR). La evaluación de esta producción se realizó en invernadero en Torreón, Coahuila, México. Se utilizó compost de estiércol bovino como sustrato (compost 50%, arena 40% y perlita 10%). Se programaron tres inoculaciones al árbol (a los 40, 74 y 152 días después de la siembra) con cuatro cepas de PGPR, los siguientes fueron los tratamientos T1: Bacillus paralicheniformis, T2: Acinetobacter guillouiae, T3: Aeromonas caviae, T4: Pseudomonas lini y Testigo: Sin bacteria, las cepas provenientes de la Poza Salada, Valle de Sobaco, Coahuila, México. Se realizaron tres cosechas en el ciclo verano-otoño-invierno 2016-2017. Se evaluaron variables agronómicas y bromatológicas para determinar la producción y calidad del follaje del árbol. Las cepas Pseudomonas lini y Bacillus paralicheniformis proporcionaron una respuesta positiva en el desarrollo de M. oleifera forrajera en el período de verano-otoño, incrementando la altura en las primeras semanas de desarrollo y proporcionando diámetros más gruesos y firmes. El rendimiento y las variables bromatológicas no presentaron diferencia entre los tratamientos, sin embargo, se produjo un forraje de buena calidad. En promedio las hojas presentaron el 13.56 % de cenizas, 70.15 % de total de nutrientes digestibles, 93.16 % de digestibilidad in vitro de la materia seca, 19.72 % de fibra detergente neutra, 25.35 % de fibra detergente ácida y 24.15 % de proteína cruda.
Compressão lexical: notas sobre um modelo semântico-histórico-construcional para análise de vocábulos derivados
Authors: Lopes Mailson dos Santos 
Published: September 2020

Discorreremos neste artigo sobre a compressão lexical ou micronarrativa, uma via de apreciação analítica para o conteúdo de vocábulos derivados, integrada ao marco teórico da Gramática das Construções. Nesse modelo, há uma percepção dos derivados como cápsulas de conteúdo semântico-lexical comprimido; assim, e.g., numa palavra como doleira, encontrar-se-ia comprimido um complexo de informações que, distendido, seria algo como ‘(i) pequena bolsa presa à frente, geralmente com um único compartimento, usada sob as roupas — especialmente por turistas —, como precaução contra roubo ou furto de cédulas (dólares, euros etc.), cartões, passaportes ou outros bens imprescindíveis em uma viagem ou deslocamento; (ii) mulher que negocia dólares norte-americanos no mercado paralelo’. Trata-se de uma proposta de análise oriunda de releituras e adaptações ao léxico das lições de Turner (1996) sobre a mente literária, inicialmente aplicada por Botelho (2004), Santos (2005) e Carmo (2005) à descrição de produtos sufixados do português contemporâneo. Baseando-se em tais trabalhos, Lopes (2016a, 2016b) fez, por primeira vez, a aplicação do supramencionado modelo teórico para o deslindamento histórico-diacrônico da semântica de vocábulos prefixados — num intercruzamento entre Etimologia, Morfologia Histórica e Gramática das Construções —, ao que seguiram alguns outros estudos (SIMÕES NETO, 2016; SOLEDADE; SIMÕES NETO; LOPES, 2017; LOPES, 2018), com aplicações e contribuições mais aperfeiçoadas. Baseando-nos em revisitações a esses e a outros trabalhos, delinearemos os principais tópicos caracterizadores da compressão lexical, apresentando algumas mostras de sua aplicação a estruturas linguísticas em sua trajetória diacrônica do latim ao português arcaico e moderno.
Pengaruh Kinerja Keuangan Terhadap Pertumbuhan Ekonomi dengan Alokasi Belanja Modal Sebagai Variabel Intervening
Authors: Ayu L Anisa , Rahayu Sri , Junaidi  
Published: September 2020

ABSTRAK
Penelitian ini bertujuan untuk menguji pengaruh kinerja keuangan terhadap pertumbuhan ekonomi dengan alokasi belanja modal sebagai variabel intervening pada Pemerintah Kabupaten/Kota di Provinsi Jambi. Variabel kinerja keuangan yang diukur adalah derajat desentralisasi fiskal, pertumbuhan PAD, efektivitas PAD, Efisiensi Keuangan dan Kontribusi BUMD. Data dianalisis dengan analisis jalur menggunakaan program AMOS berdasarkan data sekunder berbentuk data panel yang bersumber dari data APBD Kabupaten/Kota di Provinsi Jambi. Hasil penelitian menunjukkan bahwa hanya derajat desentralisasi fiskal, efektivitas PAD dan efisiensi keuangan yang berpengaruh langsung terhadap alokasi belanja modal. Selain itu, hanya variabel pertumbuhan PAD, efektivitas PAD, efisiensi keuangan dan alokasi belanja modal yang berpengaruh langsung terhadap pertumbuhan ekonomi. Variabel alokasi belanja modal hanya memediasi secara parsial pengaruh variabel derajat desentralisasi fiskal, efektivitas PAD dan efisiensi keuangan terhadap pertumbuhan ekonomi.
Kata Kunci: Kinerja Keuangan, Belanja Modal, Pertumbuhan Ekonomi.
Pengaruh Pendapatan Asli Daerah dan Dana Alokasi Umum Terhadap Pengalokasian Anggaran Belanja Modal
Authors: Pangestu p Parassela , Riany Meutia , Paramita J.S Elisabeth , Sundaning K Endah 
Published: September 2020

ABSTRAK
Penelitian ini bertujuan untuk menguji pengaruh Pendapatan Asli Daerah (PAD) dan Dana Alokasi Umum (DAU) terhadap belanja modal. Penelitian ini menggunakan sampel Kabupaten dan Kota di Provinsi Jambi periode 2009 – 2017. Ada 9 Kabupaten, 2 Kota, dan 1 Provinsi yang menjadi subjek penelitian ini, yaitu Kabupaten Batanghari, Kabupaten Bungo, Kabupaten Kerinci, Kabupaten Merangin, Kabupaten Muaro Jambi, Kabupaten Sarolangun, Kabupaten Tanjung Jabung Timur, Kabupaten Tanjung Jabung Barat, Kabupaten Tebo, Kota Jambi dan Kota Sungai Penuh, serta Provinsi Jambi. Penelitian ini menggunakan data sekunder yang diperoleh dari Laporan Keuangan masing-masing pemerintah daerah. Data penelitian berjumlah 60 data. Teknik analisis data dalam penelitian ini analisis regresi linear berganda dengan menggunakan software SPSS versi 22 for windows. Hasil penelitian adalah sebagai berikut. Hipotesis pertama, hasil menunjukkan bahwa PAD dan DAU berpengaruh terhadap belanja modal. Hipotesis kedua, PAD berpengaruh terhadap belanja modal. Hipotesis ketiga DAU tidak berpengaruh terhadap belanja modal.
Kata Kunci : Pendapatan Asli Daerah (PAD), Dana Alokasi Umum (DAU), belanja modal, Provinsi Jambi, analisis regresi linear berganda, SPSS 22
Pengaruh Good Corporate Governance dan Nilai Perusahaan Terhadap Tax Advoidance
Authors: Yetri Erzia , Haryadi Haryadi , Wahyudi Ilham 
Published: September 2020

Penelitian ini bertujuan untuk mengetahui pengaruh Good Corporate Governance yang di proxykan dengan variabel Kepemilikan Manajerial, Komisaris Independen, Komite Audit, dan Nilai Perusahaan terhadap Tax Avoidance pada perusahaan yang terdaftar di Bursa Efek Indonesia Periode 2013-2017 Populasi yang diambil dalam penelitian ini adalah seluruh perusahaan yang terdaftar di BEI. Teknik pengambilan sampel dengan menggunakan purposive sampling. Teknik analisis data yang digunakan yaitu dengan menggunakan regresi berganda. Pengujian hipotesis menggunakan uji statistik t. Hasil penelitian ini menunjukkan bahwa: (1) kepemilikan manejerial tidak berpengaruh terhadap tax avoidance, (2) komisaris independen tidak berpengaruh terhadap tax avoidance, (3) komite audit berpengaruh terhadap tax avoidance. (4) nilai perusahaan tidak berpengaruh terhadap tax avoidance.
Kata Kunci: Good Corporate Governance, Tax Avoidance, Kepemilikan Manejerial, Komisaris Independen, Komite Audit, Nilai Perusahaan.