bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of convolutional neural network to acquisition of clear images for objects with large vertical size in stereo light microscope vision system
Authors: Zhang Junhua , Li Xuefang , Zhang Yufeng 
Published: October 2019

AbstractFor an object with large vertical size that exceeds the certain depth of a stereo light microscope (SLM), its image will be blurred. To obtain clear images, we proposed an image fusion method based on the convolutional neural network (CNN) for the microscopic image sequence. The CNN was designed to discriminate clear and blurred pixels in the source images according to the neighborhood information. To train the CNN, a training set that contained correctly labeled clear and blurred images was created from an open‐access database. The image sequence to be fused was aligned at first. The trained CNN was then used to measure the activity level of each pixel in the aligned source images. The fused image was obtained by taking the pixels with the highest activity levels in the source image sequence. The performance was evaluated using five microscopic image sequences. Compared with other two fusion methods, the proposed method obtained better performance in terms of both visual quality and objective assessment. It is suitable for fusion of the SLM image sequence.
Cranial suture biomechanics in Metoposaurus krasiejowensis (Temnospondyli, Stereospondyli) from the upper Triassic of Poland
Authors: Gruntmejer Kamil , Konietzko‐Meier Dorota , Marcé‐Nogué Jordi , Bodzioch Adam , Fortuny Josep 
Published: October 2019

AbstractCranial sutures connect adjacent bones of the skull and play an important role in the absorption of stresses that may occur during different activities. The Late Triassic temnospondyl amphibian Metoposaurus krasiejowensis has been extensively studied over the years in terms of skull biomechanics, but without a detailed description of the function of cranial sutures. In the present study, 34 thin sections of cranial sutures were examined in order to determine their histovariability and interpret their biomechanical role in the skull. The histological model was compared with three‐dimensional‐finite element analysis (FEA) simulations of the skull under bilateral and lateral biting as well as skull‐raising loads for maximum and minimum principal stress. Histologically, only two sutural morphologies were recognised in the skull of Metoposaurus: interdigitated sutures (commonly associated with compressive stresses) are dominant along the entire length of the skull roof and palate; tongue‐and‐groove sutures (commonly associated with tensile stresses) are present across the maxilla. FEA shows a much more complex picture of stress type and distribution than predicted by sutures. Common to both methods is a predominance of compressive stresses which act on the skull during biting. The methods predict different stress regimes during biting in the posterior part of the skull: where histological analysis suggests compression, FEA predicts tension. For lateral biting and skull raising, histological and digital reconstructions show similar general patterns but with some variations.
Effects of western Pacific intraseasonal convection on surface air temperature anomalies over North America
Authors: Yang Ying , Zhu Zhiwei , Li Tim , Yao Mengying 
Published: October 2019

AbstractUsing the daily outgoing longwave radiation and 850‐hPa zonal wind over (10°S–30°N, 105°–150°E) during the extended boreal summer (May to October), the lifecycle of the western Pacific intraseasonal oscillation (WPISO) is divided into eight phases based on the first two principle components of multivariate empirical orthogonal function decomposition. Because of the pronounced northward propagation feature, the meridional location of the convection anomaly centre in each WPISO phase is quite different, leading to distinct surface air temperature (SAT) anomaly responses over the Northern Hemisphere, in which North America shows the most significant SAT anomalies, and the SAT anomalies vary significantly with WPISO phase. Under different WPISO phases, convection can induce different mid‐to‐high latitude Rossby wave trains emanating from East Asia to North America, resulting in different SAT anomaly patterns over North America. Four numerical experiments are conducted and demonstrate that the convection at different meridional locations in each WPISO phase could shape the pattern of the Rossby wave train and in turn lead to different SAT anomalies over North America. The results in this study are expected to provide predictability sources for the sub‐seasonal‐to‐seasonal (S2S) prediction of North American SAT anomalies.
Influence of Ibuprofen on Bone Healing After Colles' Fracture: A Randomized Controlled Clinical Trial
Authors: Aliuskevicius Marius , Østgaard Svend Erik , Hauge Ellen Margrethe , Vestergaard Peter , Rasmussen Sten 
Published: October 2019

ABSTRACTNon‐steroidal anti‐inflammatory drugs (NSAIDs) may delay bone healing. [Therefore, it is important to establish whether NSAID preparations delay bone healing and what correlations, if any, exist between different bone studies—DEXA—scanning, bone markers, roentgenology controls, and histological examination of newly formed bone]. The purpose of this prospective controlled study was to investigate whether ibuprofen affects bone mineral density, turnover biomarkers, and histomorphometric characteristics of the callus after a Colles' fracture. This study was a single‐center, triple‐blinded, randomized clinical trial. Ninety‐five patients (80 females) with displaced Colles' fracture, median age 65 (range 40–85) years were included in the study and operated on by external fixation from June 2012 through to June 2015. Eighty‐nine patients received interventional medicine and 83 completed the 1‐year follow‐up. The 7‐day ibuprofen group received 600 mg of ibuprofen three times a day (N = 29), the 3‐day ibuprofen group received ibuprofen for 3 days (N = 30) and a placebo for the following 4 days, and finally, the placebo group received a placebo for 7 days (N = 30). The primary outcome was the difference in bone mineral density between the ultra‐distal region of the injured and non‐injured radius at 3 months after surgery. The histomorphometric outcomes included the assessment of callus tissue volume and surface fractions at 6 weeks postoperatively. The biomarkers Osteocalcin and CrossLaps were measured at baseline, 1 week, 2 weeks, 6 weeks, 3 months, and 1 year. We included the results of the dropped‐out patients in the intention to treat analysis. There was no difference between treatment groups in bone mineral density, histomorphometric estimations, and changes in bone biomarkers. These findings may offer an indication of ibuprofen as a bone‐safe analgesic treatment in an acute fracture‐phase. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:545–554, 2020
Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
Authors: Barati Boldaji Reza , Akhlaghi Masoumeh , Sagheb Mohammad Mahdi , Esmaeilinezhad Zahra 
Published: October 2019

AbstractBACKGROUNDPomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence.RESULTSBased on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ (P < 0.001) and increased in the control group (P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions.CONCLUSIONSEight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry
Authentication of liquid egg composition using ATR‐FTIR and NIR spectroscopy in combination with PCA
Authors: Uysal Reyhan Selin , Boyaci Ismail Hakki 
Published: October 2019

AbstractBACKGROUNDThe starting point of this work is to propose a qualitative approach for authenticity confirmation of the composition of liquid egg products. To this end, it was aimed to detect the liquid egg authenticity and adulteration (with water) by using attenuated total reflectance Fourier‐transform infrared (ATR‐FTIR), near infrared (NIR) spectroscopy and chemometrics.RESULTSLiquid (n = 50) and dry (n = 50) samples of whole egg, egg yolk, egg white, and whole egg containing extra egg white (BXEW) and water (BXW) were prepared. Principal component analysis (PCA) models were formed using the data obtained from ATR‐FTIR and NIR measurements of liquid and dry samples. A better classification was achieved with PCA model of ATR‐FTIR measurements formed by using dry samples (100%) instead of liquid ones (80%). The best separation was obtained between dry sample groups of BXEW and BXW (adulterated). The presence of water content in liquid samples showed a negative effect on classification of the samples, while a good classification (100%) was obtained for NIR measurements of both liquid and dry sample groups. The developed PCA models achieved classification regardless of the form of egg samples (liquid or dry).CONCLUSIONThe results of the study revealed that adulterated egg samples (with water) could be qualitatively detected using ATR‐FTIR and NIR spectroscopy techniques in combination with PCA. © 2019 Society of Chemical Industry
Response of small sharks to nonlinear internal waves
Authors: Pineda Jesús , Rouse Sally , Starczak Victoria , Helfrich Karl , Wiley David 
Published: October 2019

AbstractPlankton and nekton may respond passively or actively to large‐amplitude, nonlinear internal waves (NLIW), with periods and wavelengths on the order of minutes and hundreds of meters, and the NLIW can cause direct or indirect changes in distribution. NLIW are ubiquitous in the coastal ocean, but understanding the influence of NLIW on organism response and distribution is challenging, because of NLIW unpredictability, short temporal and spatial scales, and the difficulty in resolving the biological response. Measurements of currents, temperature, and shark acoustic traces in Massachusetts Bay were used to evaluate the short‐term response of individuals as well as the mean effects on the distribution of an aggregation of small sharks, Squalus acanthias. In two NLIW events, we detected 527 and 3240 shark traces. Individuals moved up and down in response to the currents associated with the sinking and rising of the thermocline. However, mean distribution deepened during one of the events, suggesting that organisms did not merely move in concert with the thermocline oscillation, but that sharks instead might have responded actively. Measurements of vertical currents and shark's depth change during one of the NLIW events indicate that with downward currents (sinking of the thermocline), the sharks tend to react passively. However, in response to the fastest upward currents, sharks appeared to swim down, supporting an active response in the rising phase of the wave. NLIW and other high‐frequency processes can have a profound influence on the distribution of pelagic organisms, yet their ecological consequences remain largely unaccounted for.
Identification of Potential Inhibitors of Cathepsin‐B using Shape & Pharmacophore‐based Virtual Screening, Molecular Docking and Explicit Water Thermodynamics
Authors: Sharma Tanuj , Harioudh Munesh Kumar , Kuldeep Jitendra , Kumar Sushil , Banerjee Dibyendu , Ghosh Jimut Kanti , Siddiqi Mohammad Imran 
Published: October 2019

AbstractLysosome has been long understood as a vital digestive organelle. Increasing reports indicate that the lysosome also plays a crucial role in the pathogenesis of a variety of neurodegenerative diseases, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition stimulated by lysosomal dysfunction may cause age‐related neurodegeneration. Enormous efforts have been devoted to the development of effective therapeutics against Alzheimer's disease, the most debilitating neurodegenerative disease. Endopeptidase activity of the Cathepsin‐B is associated with the pathological processes. Work presented here focuses on identification of new inhibitors against Cathepsin‐B protein using diverse computational approaches together. The inhibitors identified were further tested for in‐vitro activity using enzyme based assay method. The identified inhibitors provided interesting understanding on how the water thermodynamic properties along with hydrophobic, steric, electronic, and structural requirements contribute to cathepsin‐B inhibitory activity. These water thermodynamic studies, may further be used in computer aided drug discovery pipeline to design and predict more potent derivatives of various scaffolds as cathepsin‐B inhibitors.
A novel microstrip antenna with L‐shaped slots for circularly polarized satellite applications
Authors: AboEl‐Hassan May , Hussein Khalid F. , Awadalla Kamal H. 
Published: October 2019

AbstractA novel compact design of a circularly polarized corner‐slotted microstrip antenna for satellite and Synthetic Aperture Radar applications is presented. A single probe feed is used to excite a single square patch with two L‐shaped slots added at the upper right corner and at the opposite lower left corner (or at the other two corners) to achieve circular polarization (CP) radiation. The proposed antenna has a simple shape, straightforward fabrication, and low cost. The impedance bandwidth (10 dB return loss) is approximately 600 MHz at 8.1 GHz. An axial ratio bandwidth of 170 MHz is realized. The importance of the axial ratio 3 dB bandwidth is emphasized. In addition, an analysis for the direction of rotation of the CP is given. The experimental results have a reasonable agreement with the simulation.
CREB activity is required for epidermal growth factor‐induced mouse cumulus expansion
Authors: Zhang Yu , Yang Jian , Yang Jing , Li Jia , Zhang Meijia 
Published: October 2019

AbstractThe release of a fertilizable oocyte from the ovary is dependent upon the expansion of the cumulus cells. The expansion requires cooperation between epidermal growth factor (EGF) family peptide‐activated mitogen‐activated protein kinase (MAPK)3/1 and oocyte paracrine factor‐activated‐Sma‐ and Mad‐related protein (SMAD)2/3 signaling in cumulus cells. However, the mechanism underlying (MAPK)3/1 signaling is unclear. In the present study, the EGF‐activation of EGF receptor (EGFR) induced cyclic adenosine 3′,5′‐monophosphate (cAMP) response element‐binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS‐E phosphate (KG‐501) completely blocked the EGF‐stimulated expansion‐related gene expression. EGF‐stimulated phosphorylation of CREB was completely inhibited by MAPK3/1 inhibitor U0126, suggesting that EGF‐activated MAPK3/1 results in the activation of CREB for cumulus expansion. Also, the role of EGF‐stimulated calcium signaling was studied. Calcium‐elevating reagents ionomycin and sphingosine‐1‐phosphate mimicked, but calcium chelators bis‐(o'aminophenoxy)‐ethane‐N,N,N,N‐tetraacetic acid, tetra(acetoxymethyl)‐ester, and 8‐(N,N‐diethylamino)‐octyl‐3,4,5‐trimethoxybenzoate abolished the activity of EGF on CREB phosphorylation, cumulus expansion, and expansion‐related gene expression. Furthermore, EGF‐induced cumulus expansion was inhibited by calmodulin (CaM)‐dependent protein kinase II (CaMKII) inhibitors, KN‐93 and autocamtide‐2‐related inhibitory peptide. However, the inhibition of SMAD2/3 activity by removal of oocyte from cumulus–oocyte complexes did not affect the EGF‐induced CREB phosphorylation, indicating that EGF‐activated CREB is independent of oocyte‐activated SMAD2/3 signaling. Therefore, EGF‐induced CREB activity by MAPK3/1 and Ca2+/CaMKII signaling pathways promotes the expansion‐related gene expression and consequent cumulus expansion.
How Sweet Is This? A Review and Evaluation of Preoperative Carbohydrate Loading in the Enhanced Recovery After Surgery Model
Authors: Ackerman Robert S. , Tufts Christopher W. , DePinto David G. , Chen Jeffrey , Altshuler Jaclyn R. , Serdiuk Andrew , Cohen Jonathan B. , Patel Sephalie Y. 
Published: October 2019

AbstractPreoperative carbohydrate loading is a contemporary element of the enhanced recovery after surgery (ERAS) paradigm. In addition to intraoperative surgical and anesthetic modifications and postoperative care practices, preoperative optimization is essential to good postsurgical outcomes. What was long held as dogma, a period of prolonged fasting prior to the administration of anesthesia, was later re‐examined and challenged. Along with the proposed physiologic effects of decreasing the surgical stress response and insulin resistance, preoperative carbohydrate loading was also demonstrated to improve patient satisfaction and well‐being, without an increase in perioperative complications. The benefits are most strongly observed in abdominal and cardiac surgery patients, but there has also been data which support its use in other specialties and surgeries. Barriers to the adoption of perioperative carbohydrate loading are few, but importantly include overcoming the inertia to modify older and more restrictive fasting guidelines and achieving the multidisciplinary consensus necessary to implement such changes. Despite these challenges, and with an existing body of evidence supporting its benefits, preoperative carbohydrate loading presents a significant contribution to the ERAS programs.
Synthesis and Inhibitory Effect of Some Indole‐Pyrimidine Based Hybrid Heterocycles on α‐Glucosidase and α‐Amylase as Potential Hypoglycemic Agents
Authors: Badria Farid A. , Atef Saleh , Al‐Majid Abdullah Mohammed , Ali M. , Elshaier Yaseen A. M. M. , Ghabbour Hazem A. , Islam Mohammad Shahidul , Barakat Assem 
Published: October 2019

AbstractThe Michael addition reaction of barbituric acid with chalcones incorporating the indole scaffold was achieved by using a highly efficient bimetallic Iron–palladium catalyst in the presence of acetylacetone (acac). This catalytic approach produced the desired products in a simple operation and low catalyst loading with acceptable yield of the new hybrids. All tested compounds were subjected for biological activity on α‐glucosidase and α‐amylase. The results revealed that all synthesized compounds exhibited very good activity against both enzymes when compared to positive control (acarbose). Moreover, compound 5o showed the best activity whereas its IC50 (μM) are 13.02+0.01 and 21.71+0.82 for α‐glucosidase and α‐amylase respectively. Both compounds 5o and 5l exhibited high similarity in binding mode and pose with amylase protein (4UAC). The obtained data may be used for developing potential hypoglycemic agents.
Tapered copolymers of styrene and 4‐vinylbenzocyclobutene via carbanionic polymerization for crosslinkable polymer films
Authors: Leibig Daniel , Messerle Margarita , Johann Tobias , Moers Christian , Kaveh Farzaneh , Butt Hans‐Jürgen , Vollmer Doris , Müller Axel H. E. , Frey Holger 
Published: October 2019

ABSTRACTWell‐defined polystyrene homopolymers with surface‐adhesive triethoxysilyl end group were synthesized via living carbanionic polymerization, epoxide end‐functionalization and subsequent hydrosilylation with triethoxysilane. Grafting‐to performance of polymers with various molecular weight (Mn = 3000–14,000 g mol−1) to a silicon surface was examined in dependence of reaction time, polymer concentration, solvent and number of alkoxysilyl end groups. Crosslinkable polymers for surface modification were synthesized by statistical carbanionic copolymerization of 4‐vinylbenzocyclobutene (4‐VBCB) and styrene, followed by epoxide end‐functionalization and triethoxysilane modification (Mn = 4000–14,000 g mol−1). The copolymers were characterized by 1H‐NMR, THF‐SEC, and matrix‐assisted laser desorption and ionization time‐of‐flight mass spectrometry. In situ 1H‐NMR kinetic studies in cyclohexane‐d12 provided information regarding the monomer gradient in the polymer chains, with styrene being the more reactive monomer (rs = 2.75, r4‐VBCB = 0.23). Thin polymer films on silicon wafers were prepared by grafting‐to surface modification under conditions derived for the polystyrene homopolymer. The traceless, thermally induced crosslinking reaction of the benzocyclobutene units was studied by DSC in bulk as well as in 3–6 nm thick polymer films. Crosslinked films were analyzed by atomic force microscopy, ellipsometry, and nanoindentation, showing smooth polymer films with an increased modulus. © 2019 The Authors. Journal of Polymer Science published by Wiley Periodicals, Inc. J. Polym. Sci. 2020, 58, 181–192
A model of unfrozen water content and its transport in icy permafrost soils: Effects on ground ice content and permafrost stability
Authors: Fisher David A. , Lacelle Denis , Pollard Wayne 
Published: October 2019

AbstractKnowledge of the amount of unfrozen water and its migration in permafrost soils is important for understanding physico‐chemical and biological processes. Here, we developed sub‐routines in FREZCHEM and embedded them in the WATEREGO2 soil environmental model to: (a) estimate unfrozen water content under changing soil temperatures and water–ice phase changes; and (b) determine the effects of Van der Waals (VdW) and rheological forces driven by seasonal temperature variations on the transport of residual water and the long‐term evolution of ground ice content over depths of 30 m. Together, the seasonal thermal regime and associated VdW and rheological forces on the transport of residual water lead to the evolution of distinct zones of ice‐enrichment: near the surface of permafrost, at 3–5 m, 11–13 m and 17–19 m depth. The depths of ice enrichment are a function of soil thermal diffusivity, and the time needed to evolve the ground ice content is dependent on soil type, soil water chemistry and permafrost temperature. The model can explain observed variations with depth in ground ice content of icy permafrost soils and indicate that these conditions evolve over time. The findings can be used to assess the stability of permafrost to climate change under different temperature scenarios.