bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIOMEDICINES-CINA AGAINST COVID-19: CONTROLLED PLANT DISEASES ENRICHED SCIENCE AND TECHNOLOGY COMMUNICATION GREEN ECONOMY
Authors: Datta Subhas Chandra 
Published: October 2020

The economic-plant-mulberry is infected by different pathogens causing diseases and significantly reduces silk production. Though pesticides are the most effective means of control, but they are expensive and not environment friendly. On the other hand, the ongoing spread of the novel coronavirus, forming epidemic, affecting human civilizations, because recently, no appropriate antiviral drugs for effective treatments or vaccines against COVID-19. To meet the challenge, it is reported that the therapeutic value of traditional-, complementary- and alternative-biomedicines-Artemisia nilagirica, has been used for centuries, to overcome various medical disorders. So, to concur with the situation, it will require new and more efficient solutions, technologies, and products. Present pretreatment with ultra-high-diluted biomedicines-Cina, prepared from the flowering meristems of Artemisia nilagirica (Clarke) pamp, mixed with water at an extremely low dose, were applied by foliar spray once daily for 15 days @ 10 ml/plant, against naturally occurring, root-knot-, leaf spot-, powdery mildew-, mosaic- and tukra- mulberry diseases, in field trials and silkworms rearing. Pretreatment-investigations have revealed that ultra-high-diluted-Cina, highly effective in ameliorating different mulberry-diseases by inducing their natural defense-response against pathogens-infection and leaving no residual-toxicity in the leaves to affect the growth of silkworms also. It can be concluded that the ultra-high-diluted, eco-friendly easily-available, easily applicable-Cina, at an extremely low dose, not only used as a potential-biomedical-drug against various plant-diseases, by inducing natural-defense- response, but also, it may be effective against COVID-19 for vaccinations and clinical trials by boosting the natural immune system for the improvement of Science and Technology communication cost-effectiveness green-economy and biodiversity conservations as well as bio-applications issues. And the future clinical-scientists develop all aspects of clinical-case-reports by publishing in the appropriate medical research archives, with the sincere hope that this crisis will soon be over and the whole world, may fight against the COVID-19 war, retaining normal forms of human civilizations globally.
Hyperglicemia as Predisposition Factor of Oral Candidiasis on patient with Diabetes Mellitus
Authors: Nurmansyah Dian , Stasya Elma , Ramadhani Dewi , Normaidah Normaidah , Astuti Aldiana 
Published: October 2020

Diabetes mellitus is a disease characterized by hyperglycemia or an increase in blood glucose levels. The state of hyperglycemia is one of the supporting factors for oral candidiasis infection. The purpose of this study was to determine the correlation of hyperglycemia with the incidence of Candida albicans infection in patients with Diabetes mellitus. this study was conducted on 30 respondents. Blood glucose levels and Candida albicans culture were measured using the germ tube test method. Data analysis to see the correlation using the Chi-Square test obtained Sig. (0.015 0.00.050) and it can be stated there is a correlation between variables. From the results of data analysis, it can be concluded that there is a correlation between hyperglycemia and Candida albicans infection which causes oral candidiasis in DM patients.
Metagenomic Diversity of Gut Microbiota of Gestational Diabetes Mellitus of Pregnant Women
Authors: Minarti Minarti , Triananinsi Nurhidayat , Nurqalbi Nurqalbi , Sumarni Sumarni , Kamaruddin Mudyawati 
Published: October 2020

Gestational Diabetes Mellitus (GDM) is defined as a condition in which a woman without diabetes develops abnormal glucose tolerance that is first recognized during pregnancy. GDM is a significant public health problem with an incidence of 1.9 – 3.6% of all pregnancies in Indonesia. Additionally, women with GDM during pregnancy have a high risk of developing diabetes when they are not pregnant, such as type 2 diabetes (T2D). One alternative variable in the management of T2D globally is gut microbiota. Here, to find out the role of gut microbiota in pregnancy, we characterized the stools of 30 pregnant women, each consisting of fifteen GDM-detected pregnant women, and healthy pregnant women using metagenomic approach with genome analysis by directly isolating genomic DNA from the microbiota ecosystem that occupies the digestive tract. DNA sequencing results were analyzed by MEGA 6 software with the BLASTn algorithm in NCBI. Thus fifteen GDM-detected showed high nucleotide sequence homology with the Proteobacteria at phylum level, and Escherichia, Orchobacterium, Cronobacter, Shigella, Salmonella, Enterobacter, Klebsiella, Kosakonia, Vibrio dan Gamma-Proteobacterium at genus level compared to the healthy pregnant women which found by Firmicutes at phylum level and Ruminococcus, Clostridium, Clostridiales, Lachnospiraceae, Roseburia, Weisella, Eubacterium at genus level had a higher abundance in healthy pregnant women. In this result, we found also one of the fifteen healthy pregnant women showed differential abundance with enrichment of Prevotella species. Gut microbiota of GDM-diagnosed pregnant women has more varied composition, and dominated by the phylum Proteobacteria than in normal pregnant women.
Evaluation of adaptivity of herbal peony varieties, depending on ecological and biological conditions of Moscow region
Authors: Artyukhova A. V. , Kelina A. V. 
Published: October 2020

The study, maintenance, and replenishment of the genetic collection of the herbaceous peony in the All-Russian Horticultural Institute for Breeding, Agrotechnology and Nursery is conducted since the 80s of the XX century. The article provides information on the evaluation of reproductive ability: high-productive varieties were revealed – Dawn Pink, Early Scout, Vostok, Yubilej Revolyutsii, Seraphim, Goldich, Ufimskie Zori, Pervaya Radost’, Gloirette, Marry Eddy Jones, Pobeda, Podmoskovnye Vechera, Old Lace, Agidel’, Tomas Waar, Nezhnyj, Martha Bulloch, Mihail Lomonosov, Parkovyj, Pfeiff er’s Red Triumph, Odile et al., their reproductive capacity is estimated of 8-10 points; resistant varieties to Botrytis paeonie Qud were identified – Mamino Serdechko, Varen’ka, Orlenok, El’brus, Moguchij, Polonez, Rossiya, Brat Moguchego, SHkol’nyj Val’s, Valentina Tereshkova, Parkovyj 1, Zhemchuzhina Urala, Zor’ka, Rhapsody, President Wilson, The Fawn, Moon Glow, Yellow King, Waikiki, Белый парус, Sinbad, Gene Wild; varieties strongly aff ected by Cronartium fl accidum (Alb. et Schw.) Wint.) were identified – Lunnaya Doroga, Tajfun, Parkovyj 2, Nahodka, Agidel’, Ufimskie Zori, Kuril’skie Ostrova, Shirley Temple, M-me Calot, M-me Claude Tain, Goldich. The analysis of weather conditions in the years of research is given. Varieties that are resistant to adverse conditions are identified, their significance is determined and in the future the possibility of propagation and use in landscaping, as well as preservation in collection stands. Directions for further study of the collection’s varieties are outlined. Keywords: peony herbaceous, collection, decorative qualities, weather conditions, adaptability
Promising forms of apricot for the conditions of the Orenburg Urals
Authors: Beskopyl’naya V. V. , Mushinskiy A. A. , Aminova E. V. , Saudabayeva A. Zh. 
Published: October 2020

The article describes new forms of apricot revealed in the sharply continental climate of the steppe zone of the southern Urals. The research was carried out in the period 2014-2020 on the basis of the Orenburg experimental station of horticulture and viticulture of the All-Russian Horticultural Institute for Breeding, Agrotechnology and Nursery. The experiment was conducted on annual seedlings in rain-fed conditions on a collection site in 2013, the layout of trees is 6×4 m. The soil of the experimental site and the adjacent massif is southern carbonate Chernozem, low-power, medium-loamy. According to productivity, fruit taste and winter hardiness (damage of 2 points), three forms of apricot SIZV-6-1, NO. 40, and D-36 were identified with the following characteristics: average fl owering period (from April 27 to May 1), the height is from 2 (D-36) to 3.5 (SI-ZV-6-1) meters, the yield is from 9.8 kg (form 40) to 15.7 kg per tree (form D-36). The revealed forms SI-ZV-6-1, No. 40 have a good, harmonious, sweet taste of fruits. The exception is the D-36 form, which has a sourness in the pulp. For all the time of research, the forms SI-SV-6-1, D-36, No. 40 were not aff ected by clasterosporium and moniliosis. The climatic conditions of the Orenburg region during the period of observation of phenological parameters were very diverse, which allowed us to give a comprehensive assessment of new forms of apricot. The information obtained during monitoring is new and can be used in breeding work.
Promising varieties and forms of golden currant (Ribes aureum Pursh.) in the conditions of the steppe zone of the Southern Urals
Authors: Aminova E. V. , Mushinskiy A. A. , Feshchenko E. M. 
Published: October 2020

The article presents the results of many years of work on the study of golden currant (Ribes aureum Pursh.) in the conditions of the steppe zone of the Southern Urals. The study was carried out on the experimental plot of Orenburg Experimental Station of Horticulture and Viticulture in the 2009-2019. The object of research was varieties Samocvet, Uralskaya and forms 1-7, 2-1, 2-9, 2-6, 3-2 of golden currant. The soil cover of the experimental site was represented by ordinary chernozem, the humus content in the arable layer was 2.7-3.0 %, the phosphorus content was 18.4 mg/kg, potassium – 358.6 mg/kg, nitrogen – 96.6 mg/kg. There was shown the development of the scientific foundations of crop breeding in the steppe zone of the Southern Urals, where the gene pool was first created, from which new varieties with a complex of economically valuable traits were developed, and promising forms were identified. As a result of the research, promising varieties and forms were distributed by maturation period into 2 groups: medium (Samotsvet, Uralskaya, 1-7, 2-1, 2-9) and late (2-6, 3-2). Adapted varieties (Samotsvet, Uralskaya) and forms (2-6, 2-1) were revealed, which are distinguished by high productivity from a bush (from 4.8 to 5.6 kg), number of berries in a cluster (from 4.6 to 6 pcs. ), berry weight (from 3.4 to 4.1 g). A brief economic and biological characteristics of selected forms and varieties are given.
Rhizogenesis in clonal apple rootstocks (Malus Mill.) in vitro depending on the influence of abiotic factors
Authors: Bjadovskiy I. A. 
Published: October 2020

In vitro culture at the rooting stage the aft ereff ect of the use of earlier (during proliferation) growth regulators with cytokinin activity (6-benzylaminopurine and thidiazuron) and the eff ect of lamps of diff erent spectral composition on the percentage of rooting and biometric parameters of the development of the roots of clonal apple rootstocks were studied. The following forms of apple clonal rootstocks were taken as objects of research: 54-118, 57-490, 57-545, ММ 106 and М 26. The research methods used at the stages of in vitro culture studies corresponded to those generally accepted for this section of research. Studies were performed on two variants of explants, one part was cultured at the proliferation stage on media with 6-benzylaminopurine and the other on media with tidiazurone. It was found that explants that were cultivated at the stage of proliferation on media with thidiazuron had a tendency to a subsequent increase in the number of roots (at the stage of rooting) by one microscopic cut, in comparison with cultivation on media with 6-benzylaminopurine, by 1.1-1.3 times, and this regularity was observed in all studied clonal rootstocks of the apple tree. It was noted that when explants were illuminated, explants had a greater percentage of rooting when illuminated with phytolamps in comparison with lighting with lamps with a color temperature of 6500K by 1.1-1.4 times in all studied apple rootstocks, and an increase in the number of roots per one microstalk was observed (for excluding rootstock 57-490), by 1.1-1.9 times. During the research, the specificity of rooting of clonal apple rootstocks was observed under the infl uence of the composition of light and the use of 6-benzylaminopurine and thidiazuron at the stage of proliferation, which was expressed in a higher ability to rhizogenesis of some rootstocks compared to others. The rootstocks MM 106 (83.3-93.9 %) and M26 (87.8-92.7 %) had a greater percentage of rooting, according to the average number of roots per one microcut, rootstocks 57-545 (15.4 pcs.), MM 106 (11.2 pcs.), and M 26 along the average root length (27.0 mm).
Surgical management of incidentally discovered low-grade gliomas
Authors: Gogos Andrew J. , Young Jacob S. , Pereira Matheus P. , Morshed Ramin A. , Potts Matthew B. , Hervey-Jumper Shawn L. , Berger Mitchel S. 
Published: October 2020

OBJECTIVE
Although most patients with low-grade glioma (LGG) present after a seizure, a small proportion is diagnosed after neuroimaging is performed for a sign or symptom unrelated to the tumor. While these tumors invariably grow, some surgeons argue for a watchful waiting approach. Here, the authors report on their experience in the surgical treatment of patients with incidental LGG (iLGG) and describe the neurological outcomes, survival, and complications.

METHODS
Relevant cases were identified from a prospective registry of patients undergoing glioma resection at the University of California, San Francisco, between 1997 and 2019. Cases were considered iLGG when the lesion was noted on imaging performed for a reason unrelated to the tumor. Demographic, clinical, pathological, and imaging data were extracted from the electronic medical record. Tumor volumes, growth, and extent of resection were calculated from pre- and postoperative volumetric FLAIR sequences.

RESULTS
One hundred thirteen of 657 (17.2%) first-time resections for LGG were for incidental lesions. The most common reasons for the discovery of an iLGG were headaches (without mass effect, 34.5%) or trauma (16.8%). Incidental tumors were no different from symptomatic lesions in terms of laterality or location, but they were significantly smaller (22.5 vs 57.5 cm3, p < 0.0001). There was no difference in diagnosis between patients with iLGG and those with symptomatic LGG (sLGG), incorporating both molecular and pathological data. The median preoperative observation time for iLGG was 3.1 months (range 1 month–12 years), and there was a median growth rate of 3.9 cm3/year. Complete resection of the FLAIR abnormality was achieved in 57% of patients with incidental lesions but only 23.8% of symptomatic lesions (p < 0.001), and the residual volumes were smaller for iLGGs (2.9 vs 13.5 cm3, p < 0.0001). Overall survival was significantly longer for patients with incidental tumors (median survival not reached for patients with iLGG vs 14.6 years for those with sLGG, p < 0.0001). There was a 4.4% rate of neurological deficits at 6 months.

CONCLUSIONS
The authors present the largest cohort of iLGGs. Patient age, tumor location, and molecular genetics were not different between iLGGs and sLGGs. Incidental tumors were smaller, a greater extent of resection could be achieved, and overall survival was improved compared to those for patients with sLGG. Operative morbidity and rates of neurological deficit were acceptably low; thus, the authors advocate upfront surgical intervention aimed at maximal safe resection for these incidentally discovered lesions.
The value of intraoperative MRI in recurrent intracranial tumor surgery
Authors: Wang Sophie S. , Selge Friederike , Sebök Martina , Scheffler Pierre , Yang Yang , Brandi Giovanna , Winklhofer Sebastian , Bozinov Oliver 
Published: October 2020

OBJECTIVE
Identifying tumor remnants in previously operated tumor lesions remains a challenge. Intraoperative MRI (ioMRI) helps the neurosurgeon to reorient and update image guidance during surgery. The purpose of this study was to analyze whether ioMRI is more efficient in detecting tumor remnants in the surgery of recurrent lesions compared with primary surgery.

METHODS
All consecutive patients undergoing elective intracranial tumor surgery between 2013 and 2018 at the authors’ institution were included in this retrospective cohort study. The cohort was divided into two groups: re-craniotomy and primary craniotomy. In contrast-enhancing tumors, tumor suspicion in ioMRI was defined as contrast enhancement in T1-weighted imaging. In non–contrast-enhancing tumors, tumor suspicion was defined as hypointensity in T1-weighted imaging and hyperintensity in T2-weighted imaging and FLAIR. In cases in which the ioMRI tumor suspicion was a false positive and not confirmed during in situ inspection by the neurosurgeon, the signal was defined as a tumor-imitating ioMRI signal (TIM). Descriptive statistics were performed.

RESULTS
A total of 214 tumor surgeries met the inclusion criteria. The re-craniotomy group included 89 surgeries, and the primary craniotomy group included 123 surgeries. Initial complete resection after ioMRI was less frequent in the re-craniotomy group than in the primary craniotomy group, but this was not a statistically significant difference. Radiological suspicion of tumor remnants in ioMRI was present in 78% of re-craniotomy surgeries and 69% of primary craniotomy surgeries. The incidence of false-positive TIMs was significantly higher in the re-craniotomy group (n = 11, 12%) compared with the primary craniotomy group (n = 5, 4%; p = 0.015), and in contrast-enhancing tumors was related to hemorrhages in situ (n = 9).

CONCLUSIONS
A history of previous surgery in contrast-enhancing tumors made correct identification of tumor remnants in ioMRI more difficult, with a higher rate of false-positive ioMRI signals in the re-craniotomy group. The majority of TIMs were associated with the inability to distinguish contrast enhancement from hyperacute hemorrhage. The addition of a specific sequence in ioMRI to further differentiate both should be investigated in future studies.
PENGARUH Trichoderma asperellum DAN KOMPOS TERHADAP PERTUMBUHAN DAN HASIL TANAMAN BAWANG MERAH VARIETAS LEMBAH PALU (Allium L.x Wakegi Araki)
Authors: Jaya Kasman , Idris Idris , Yuliana  
Published: October 2020

This study aims to determine the effect of giving T. asperellum and compost on the growth and yield of shallots of the Palu Valley variety. This research was conducted on July to September 2019 in Oloboju Village, Sigi Biromaru District, Sigi Regency, Central Sulawesi Province. This research is a kind of experimental research that is designed by using a Randomized Group Design with grouping based on watering time. The treatments tested consisted of: P0 = Control (without treatment), P1 = T. asperellum 48g + 12 liters of water, P2 = T. asperellum 48g + 12kg compost and P3 = 12kg compost. To determine the effect of the treatment being tried, a diversity test was conducted. If the diversity test results show a real influence, then proceed with the Honestly Significant Difference test (BNJ) α = 0.05 to find out the differences between treatments. Treatment of various combinations of T. asperellum and compost significantly affected plant height at ages 15 and 25 HST, but had no significant effect on the number of leaves, leaf fresh weight, root fresh weight, leaf dry weight, root dry weight, number of tubers per clump, fresh tuber weight per clump, fresh tuber weight per plot and fresh tuber weight per hectare. The compost treatment gives a better effect on the height of plants aged 15 HST (average 15.09cm) and 25 HST (average 19.86cm).
PENERAPAN MODEL PEMBELAJARAN QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS VII A MTs. ALKHAIRAAT BIROMARU PADA MATERI ARITMATIKA SOSIAL
Authors: Sultan Lisdayanti , Hajerina Hajerina 
Published: October 2020

The basic problem in this study is the low students learning outcomes in social arithmetic material regarding the profit, loss and percentage and discount in class VII A MTs Alkhairaat Biromaru 2017/2018 school year. There are several causes of the low students learning outcomes including teachers are still learning centers so students still tend to be passive in learning. This makes students become inactive, recultant, afraid and ashamend to ask. Therefore, to improve the learning outcomes of students of class VII A MTs Alkhairaat Biromaru and maximize learning, the researcher applied a quantum learning model, which is a learning model whose entire learning process can sharpen understanding and memory, and make learning a pleasant and useful process, so that learning becomes more motivated. The quantum learning model consists of 6 learning components, namely : 1. grow, 2. natural, 3. name, . demonstrate, 5. repeat, 6. Celebrate This research is a classroom action research using qualitative approachthat aims to improve the learning outcomes of class VII A MTs Alkhairaat Biromaru sudents. The subject of this study were all students of class VII A totaling 21 people. In the research tht has been carried out, the result of his study indicate that learning activities have been going well and have increased in each cycle. This can be seen from the percentage of completeness of classical learning. In the final test of the first cycle reached the average score of students that is 71,43% with the amount of absorption of 15 students. Then in the final test the second cycle increased to 85,71% in good qualifications. With the number of students who get individual absorption of 18 students.
Subcutaneous Administration of AMD3100 into Mice Models of Alzheimer’s Disease Ameliorated Cognitive Impairment, Reduced Neuroinflammation, and Improved Pathophysiological Markers
Authors: Gavriel Yuval , Rabinovich-Nikitin Inna , Ezra Assaf , Barbiro Becki , Solomon Beka 
Published: October 2020

Background: Alzheimer’s disease (AD), the prevalent dementia in the elderly, involves many related and interdependent pathologies that manifest simultaneously, leading to cognitive impairment and death. Amyloid-β (Aβ) accumulation in the brain triggers the onset of AD, accompanied by neuroinflammatory response and pathological changes. The CXCR4/CXCL12 (SDF1) axis is one of the major signal transduction cascades involved in the inflammation process and regulation of homing of hematopoietic stem cells (HSCs) within the bone marrow niche. Inhibition of the axis with AMD3100, a reversible antagonist of CXCR4 mobilizes endogenous HSCs from the bone marrow into the periphery, facilitating the recruitment of bone marrow-derived microglia-like cells into the brain, attenuates the neuroinflammation process that involves release of excitotoxic markers such as TNFα, intracellular Ca2 +, and glutamate and upregulates monocarboxylate transporter 1, the major L-lactate transporter in the brain. Objective: Herein, we investigate if administration of a combination of AMD3100 and L-lactate may have beneficial effects in the treatment of AD. Methods: We tested the feasibility of the combined treatment for short- and long-term efficacy for inducing endogenous stem cells’ mobilization and attenuation of neuroinflammation in two distinct amyloid-β-induced AD mouse models. Results: The combined treatment did not demonstrate any adverse effects on the mice, and resulted in a significant improvement in cognitive/memory functions, attenuated neuroinflammation, and alleviated AD pathologies compared to each treatment alone. Conclusion: This study showed AMD3100’s beneficial effect in ameliorating AD pathogenesis, suggesting an alternative to the multistep procedures of transplantation of stem cells in the treatment of AD.