bluuebunny/crossref_metadata_2025_split huggingface dataset:
KCNQ1OT1 promotes ovarian cancer progression via modulating MIR‐142‐5p/CAPN10 axis
Authors: Liu Hongli , Chen Ruixin , Kang Fenhong , Lai Haiqing , Wang Yanlong 
Published: January 2020

AbstractBackgroundLong non‐coding RNA (lncRNA) has been regarded as crucial regulator for cancer progression. Roles of KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in cancers including osteosarcoma and colon cancer have been previously reported. However, its role in ovarian cancer (OC) remains unclear.MethodsExpression level of KCNQ1OT1 on OC cells and normal cell was analyzed with quantitative real‐time PCR. Gain and loss‐of‐function experiments were performed to analyze the biological roles of KCNQ1OT1 in OC. Moreover, whether KCNQ1OT1 functions its role via mediating MICRORNA‐142‐5p (MIR‐142‐5p)/calpain 10 (CAPN10) axis was analyzed. In addition, effects of KCNQ1OT1, MIR‐142‐5p, and CAPN10 on overall survival of OC patients were analyzed at Kaplan–Meier plotter website.ResultsWe showed KCNQ1OT1 was elevated expression in OC cells and indicated poorer overall survival of OC patients. Besides, we found KCNQ1OT1 could promote OC cell proliferation and migration in vitro. Moreover, MIR‐142‐5p was found reduced expression, while CAPN10 was found elevated expression in OC cells compared with normal cell. Kaplan–Meier curve analysis showed low MIR‐142‐5p or high CAPN10 expression were indicators for poorer overall survival of OC patients. At length, we showed KCNQ1OT1 could regulate OC development via MIR‐142‐5p/CAPN10 axis.ConclusionsTaken together, KCNQ1OT1 upregulates CAPN10 expression via sponging MIR‐142‐5p, thus promoting the proliferation and migration of OC.
A new method for solving the eikonal equation in the spherical computing domain
Authors: Feng Guoxu , Huang Jun 
Published: January 2020

AbstractIn order to overcome the problem of singularities and nonuniform grids arising when solving eikonal equation in spherical coordinate systems, a spherical Cartesian coordinate system is defined and the Hamiltonian form of the eikonal equation according to this coordinate system is given. A modified velocity function that can transform spherical coordinate system–based eikonal equation into ones based on a spherical Cartesian coordinate system is deduced by using a differential geometric method where a layered distribution of the velocity function is assumed. After comparing the results of using this approach with the traditional method of solving eikonal equation based on a spherical coordinate system, the viability of the transformation to a spherical Cartesian coordinate system based on a modified velocity function is proven. Despite the assumption of a layered distribution of the velocity function, it is also proven that the method will hold for a velocity function under any three‐dimensional distribution. The new method overcomes problems present in traditional approaches and opens up a new way of solving eikonal equation in a spherical computational domain.
Does the Feldstein–Horioka puzzle exist among South Asian countries? A regime‐switching approach
Authors: Patra Suresh Kumar , Mohanty Ranjan Kumar 
Published: January 2020

AbstractA plethora of literature has been undertaken to study the validity of the Feldstein–Horioka (FH) puzzle. However, divergent views continue to persist in the FH puzzle literature. This study explores the empirical validity of the FH puzzle in the case of South Asian countries using annual data from 1960 to 2017. Both panel data approach and Markov‐switching regression approach are used to empirically analyze the FH puzzle. The results of the cointegration test confirm the long‐run relationships between saving and investment in the selected South Asian countries. The results of Markov‐switching regression confirm that the saving‐retention coefficient has shifted from high to low values and also from low to high values. Thus, the FH puzzle exists for a particular time period and mostly depends on the regime shifts in the South Asian countries. The results of panel fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) methods also confirm that FH puzzle holds for the South Asian countries. Therefore, the study suggests that any saving promotion policies are desirable for enhancing investment among the South Asian regions.
Melt crystallization and segmental dynamics of poly(ethylene oxide) confined in a solid electrolyte composite
Authors: Huang Yage , Ma Mingchao , Guo Yunlong 
Published: January 2020

ABSTRACTThe isothermal melt crystallization and the corresponding segmental dynamics, of a high molecular weight poly(ethylene oxide) (PEO) confined by Li7La3Zr2O12 (LLZO) particles in solid electrolyte composites, were monitored by differential scanning calorimetry (DSC) and dielectric relaxation spectroscopy (DRS), respectively. Our results show that the overall crystallinity is positively correlated with the surface area of LLZO particles. The primary and secondary crystallization processes are identified by a modified Avrami equation, while two dynamic modes, the
α relaxation and
α′ relaxation, were in the DRS measurements. The results reveal an unambiguous correlation between the primary crystallization and the
α relaxation, while a correlation between the second crystallization and the
α′ relaxation concurrently exist in the electrolyte composites. © 2020 Wiley Periodicals, Inc. J. Polym. Sci. 2020, 58, 466–477
Effect of mechanical insufflation‐exsufflation in children with neuromuscular weakness
Authors: Veldhoen Esther S. , Verweij‐van den Oudenrijn Laura P. , Ros Leandra A. , Hulzebos Erik H. , Papazova Diana A. , van der Ent Cornelis K. , van der Pol Ludo W. , Nijman Joppe , Wösten‐van Asperen Roelie M. 
Published: January 2020

AbstractIntroductionChildren with neuromuscular diseases develop cough impairment. Airway clearance techniques (ACTs) may help to prevent recurrent respiratory tract infections (RTIs). A commonly used ACT is mechanical insufflation‐exsufflation (MI‐E), but evidence for efficacy is limited. We hypothesize that MI‐E has beneficial effect on RTI related hospital admission rate.MethodsIn this single‐center retrospective study, we reviewed all children who used daily MI‐E between 2005 till June 2019. Primary outcome studied was the number of RTIs requiring hospital admission. Patient satisfaction and burden experienced by MI‐E use were explored by questionnaires using a Likert scale. The relative number of RTIs requiring admission and the number of admission days per eligible period before and after the introduction of MI‐E were compared using the Friedman test and the Wilcoxon signed‐rank test.ResultsThirty‐seven children were included.The median number of RTI related hospital admissions per 1000 eligible days after the introduction of MI‐E was 0.9 (interquartile range [IQR] 0.0‐3.1) compared to the 3 preceding years (median 3.7; IQR 1.4‐5.9; P = .006). The median number of RTI related admission days per 1000 eligible days after the introduction of MI‐E was significantly lower with a median of 2.7 (IQR 0.0‐17.4) compared to the 3 preceding years (median 33.6; IQR 15.0‐51.1; P = .001). Patient satisfaction was high with low burden, even in patients who discontinued treatment.ConclusionA significantly lower number of RTIs requiring hospital admission and shorter admission duration after the introduction of MI‐E was found, with high patient satisfaction and low burden.
Primary malignant lung tumors in children: A report from the Australian Childhood Cancer Registry, 1983‐2015
Authors: Youlden Danny R. , Foresto Steven A. , Aitken Joanne F. 
Published: January 2020

AbstractLung cancers in children under the age of 15 are very uncommon, with a scarcity of literature describing patient characteristics and survival. This study assessed first primary malignant cancers occurring in the trachea, bronchus, or lung (International Classification of Diseases for Oncology, 3rd edition [ICD‐O‐3] codes C33‐C34) for the period 1983‐2015, using data from the population‐based Australian Childhood Cancer Registry. Variables of interest included morphology, sex, age group, and metastatic status at diagnosis. Mode of treatment was also assessed where possible. The Kaplan‐Meier method was used to calculate 5‐year observed survival. Of the 53 in‐scope patients, almost half (n = 23, 43%) were diagnosed with pleuropulmonary blastoma and a further 8 (15%) had a carcinoid tumor. Few of the patients with details available on stage at diagnosis (n = 7 of 43, 16%) presented with metastatic disease. Surgical excision was the most common treatment (30 of 37 children, 81%), with two‐thirds (n = 28 of 43, 65%) receiving chemotherapy. Five‐year observed survival was estimated to be 74% (95% CI = 61%‐85%). Our results represent one of the largest and most complete population‐based cohorts of children with primary malignant lung cancers available to date. Detection of childhood lung cancer can be difficult due to the rarity of this disease and symptoms that are typically nonspecific.
Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein–protein interactions
Authors: Allen Mark D. , Bycroft Mark , Zinzalla Giovanna 
Published: January 2020

AbstractBRG1/SMARCA4 and its paralog BRM/SMARCA2 are the ATPase subunits of human SWI/SNF chromatin remodeling complexes. These multisubunit assemblies can act as either tumor suppressors or drivers of cancer, and inhibiting both BRG1 and BRM, is emerging as an effective therapeutic strategy in diverse cancers. BRG1 and BRM contain a BRK domain. The function of this domain is unknown, but it is often found in proteins involved in transcription and developmental signaling in higher eukaryotes, in particular in proteins that remodel chromatin. We report the NMR structure of the BRG1 BRK domain. It shows similarity to the glycine‐tyrosine‐phenylalanine (GYF) domain, an established protein–protein interaction module. Computational peptide‐binding‐site analysis of the BRK domain identifies a binding site that coincides with a highly conserved groove on the surface of the protein. This sets the scene for experiments to elucidate the role of this domain, and evaluate the potential of targeting it for cancer therapy.
Strictly dissipative stabilization of multiple‐memory Markov jump systems with general transition rates: A novel event‐triggered control strategy
Authors: Xie Wenqian , Zhang Ruimei , Zeng Deqiang , Shi Kaibo , Zhong Shouming 
Published: January 2020

SummaryThis paper investigates the strictly dissipative stabilization problem for multiple‐memory Markov jump systems with network communication protocol. Firstly, for reducing data transmission, we put forward a novel mode‐dependent event‐triggered communication scheme based on aperiodically sampled data. Secondly, a Markov jump system with general transition rates is considered to make the result more applicable, where the transition rates of some jumping modes allow to be completely known, or partially known, or even completely unknown. Thirdly, a less restrictive Lyapunov‐Krasovskii functional, which is only required to be positive definite at end points of each subinterval of the holding intervals, is first introduced for event‐triggered control issue. Based on the above methods, a sufficient condition with less conservatism is obtained to ensure the stochastic stability and dissipativity of the resulting closed‐loop system. Meanwhile, an explicit design method of the desired controller is achieved. Finally, two numerical examples are presented to demonstrate the effectiveness and advantage of the proposed method.
A Highly Sensitive and Stable SERS Sensor for Malachite Green Detection Based on Ag Nanoparticles In Situ Generated on 3D MoS2 Nanoflowers
Authors: Jiang Jiayu , Shen Qihui , Xue Peng , Qi Hui , Wu Yunpeng , Teng Yifei , Zhang Yuwan , Liu Yan , Zhao Xudong , Liu Xiaoyang 
Published: January 2020

AbstractThe hybrid plasmon composition based on MoS2 has been extensively studied as a higher disposition surface enhanced Raman scattering (SERS) substrate. In this paper, a novel silver nanoparticle based SERS substrate was developed via in situ microwave synthesis approach on a three dimensional (3D) MoS2 nanoflower (MoS2 NF/ Ag NPs). The prepared SERS sensor has strong SERS activity on malachite green (MG), the Raman enhancement factor (EF) is as high as 1.46×1012. The standard Raman signal peak of MG at 1618 cm−1 has a good linear relationship at 10−12 ‐ 10−2 mol⋅L−1. The limit of detection (LOD) was calculated as approximately 10−14 mol⋅L−1, which shows the good prospects for MG's microtests. In addition, the SERS sensor still shows good SERS performance stability after 112 days, which improves the shelf life of the SERS sensor and can be effectively applied to fishery water monitoring.
A Novel and Efficient Dyes Degradation Using Bentonite Supported Zero‐Valent Iron‐Based Nanocomposites
Authors: Sabouri Mohammad Reza , Sohrabi Mahmood Reza , Moghaddam Ali Zeraatkar 
Published: January 2020

AbstractIn this research, different nanocomposites were synthesized based on bentonite supported with zero‐valent iron in mono‐, bi‐, and tri‐metallic systems and used to degrade two model anionic dyes, methyl orange and Congo red, from wastewaters. The synergic effect between bentonite and the nanoscale zero‐valent iron‐based tri‐metallic system was investigated along with degradation efficiencies. It was found out that bentonite supported with Fe−Cu‐Ag tri‐metallic nanoscale system yields higher degradation efficiency and maximum synergic effect for both of dyes occurs, especially at acidic medium. Therefore, the characterization of this nanocomposites was conducted by BET, FTIR, SEM‐EDX, TEM and XRD which demonstrated successful loading of nanoscale Fe−Cu‐Ag tri‐metallic onto bentonite clay. All involved variables affecting the dye degradation efficiencies were modeled and optimized using central composite design under batch adsorption procedure. The Nelder‐Mead non‐linear optimization algorithm was used and the outcomes showed the optimum conditions regarding the removal of 300 ppm of both dyes, for the nanocomposites dose of 4.0 mg.mL−1, pH of 3 and contact time of 18 min were attained. Furthermore, dyes adsorption kinetics were investigated. In addition, the proposed nanocomposite was successfully applied to reduce the concentration of methyl orange and Congo red as hazardous dyes in the water and wastewater samples.
1H‐NMR, Photophysical, and pH Studies of 4‐(4,5‐Diphenyl‐1H‐imidazol‐2‐yl)benzaldehyde through Experimental and DFT Theoretical Analysis
Authors: Anandhan Karnambaram , Cerón Margarita , Ceballos Paulina , Ramos‐Hernández Rodrigo , Perumal Venkatesan , Pérez‐Gutiérrez Enrique , Sosa‐Rivadeneyra Martha , Thamotharan Subbiah , Percino M. Judith 
Published: January 2020

AbstractIn the present study the molecular structure of compound 4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)benzaldehyde [DPI‐BA] and its optoelectronic properties are reported. The SCXRD analysis revealed that DPI‐BA crystallizes in the Orthorhombic crystal system and Pca21 space group with Z=4. The intermolecular N‐H⋅⋅N interaction generates a one‐dimensional chain. An interesting halochromic behavior was observed for the DPI‐BA in THF:H2O (9:1) by varying the pH analysis. The fluorescence properties of neutral and acid‐base solutions were monitored by UV‐vis and 1D, 2D‐NMR studies. The HCl vapor was bubbled to the DPI‐BA in the DMSO‐d6 solution and the corresponding fluorescence wavelength changed from green (λem 501 nm) to blue (λem 459 nm). In the case of a basic pH solution was made by adding NaOH flakes to the DPI‐BA DMSO‐d6 solution and then the fluorescence wavelength changed from green to orange (λem 595 nm). The λmax of PL emission could be correlated to intermolecular charge transfer (ICT). The optical absorption and cyclic voltammetry measurement were performed to determine the bandgap. Besides, the quantitative analysis of intermolecular interactions through PIXEL, QTAIM, NBO, GIAO‐DFT methods and DFT studies was correlated to the experiments.
Serum 25-hydroxyvitamin D concentration in childhood and risk of islet autoimmunity and type 1 diabetes: the TRIGR nested case–control ancillary study
Authors:   TRIGR Investigators, Miettinen Maija E. , Niinistö Sari , Erlund Iris , Cuthbertson David , Nucci Anita M. , Honkanen Jarno , Vaarala Outi , Hyöty Heikki , Krischer Jeffrey P. , Knip Mikael , Virtanen Suvi M. 
Published: January 2020

Abstract
Aims/hypothesis
Our aim was to study the association between serum 25-hydroxyvitamin D (25OHD) concentration and islet autoimmunity and type 1 diabetes in children with an increased genetic risk of type 1 diabetes.

Methods
Serum samples for 25OHD measurements were obtained in the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) ancillary study (Divia) from children in 15 countries. Case children (n = 244) were defined as having positivity for at least two out of four diabetes-associated autoantibodies measured at any one sample. For each case child, two control children were selected matched for country and date of birth (±1 year) (n = 488). Of the case children, 144 developed type 1 diabetes. Serum 25OHD was measured repeatedly in infancy and childhood and was compared according to age at the first seroconversion (at 6, 12 and 18 months prior to and at seroconversion) and calendar age (0, 6, 12 and 18 months).

Results
In children with islet autoimmunity, mean serum 25OHD concentration was lower 18 months prior to the age of first seroconversion of the case children compared with the control children (57.7 vs 64.8 nmol/l, p = 0.007). In children with type 1 diabetes (n = 144), mean serum 25OHD concentration was lower 18 months prior to the age of the first seroconversion (58.0 vs 65.0 nmol/l, p = 0.018) and at the calendar age of 12 months (70.1 vs 75.9 nmol/l, p = 0.031) than in their control counterparts. Analyses were adjusted for month of sample collection, human leucocyte antigen genotype, maternal type 1 diabetes and sex.

Conclusions/interpretation
The results suggest that early postnatal vitamin D may confer protection against the development of type 1 diabetes.

Trial registration
ClinicalTrials.gov NCT00179777
Technische Umsetzung der Qualitätssicherung bei der intravitrealen operativen Medikamenteneingabe (IVOM)
Authors: Bucher F. , Mussinghoff P. , Kühn T. , Stahl A. , Böhringer D. 
Published: January 2020

Zusammenfassung
Hintergrund
Eine erfolgreiche Qualitätssicherung bei der intravitrealen operativen Medikamenteneingabe (IVOM) setzt eine komplexe informationstechnologische Infrastruktur voraus. Eine ortsungebundene Datenverfügbarkeit, die Standardisierung klinischer Daten sowie die Integration umfangreicher und aktuell nicht standardisierter Bilddokumente aus der Kohärenztomographie sowie die Einhaltung datenschutzrechtlicher Vorgaben stellen wesentliche Herausforderungen dar.

Ziel der Arbeit
In diesem Beitrag werden technische und datenschutzrechtliche Grundsätze bei der technischen Implementierung beleuchtet.

Material und Methoden
Es erfolgt eine systematische Darstellung und Diskussion wesentlicher Teilaspekte bei der Implementierung einer Qualitätssicherung bei IVOM.

Ergebnisse
Im Bereich der Netzwerkstruktur haben Web-basierte Anwendungen ergänzt um lokale virtuelle private Netzwerke (VPN) und/oder andere Softwareinstanzen den früher üblichen Datenträgeraustausch ersetzt. Bei der Erfassung von Behandlungsdaten spielt die Standardisierung der Daten z. B. durch Umwandlung der Visusdaten in „logMAR“ eine wichtige Rolle. Multiple optische Kohärenztomographen mit nicht standardisierten Datenformaten erschweren die Anbindung an eine allgemeine Qualitätssicherungsstruktur sowie die Vergleichbarkeit der Daten.

Diskussion
Internationale Standards werden dies in der näheren Zukunft vermutlich erleichtern. Bis dahin müssen individuelle Lösungen vor Ort gefunden werden.
Interannual and interdecadal impact of Western North Pacific Subtropical High on tropical cyclone activity
Authors: Wu Qiong , Wang Xiaochun , Tao Li 
Published: January 2020

AbstractIn this study, we analyzed the impacts of Western North Pacific Subtropical High (WNPSH) on tropical cyclone (TC) activity on both interannual and interdecadal timescales. Based on a clustering analysis method, we grouped TCs in the Western North Pacific into three clusters according to their track patterns. We mainly focus on Cluster 1 (C1) TCs in this work, which is characterized by forming north of 15° N and moving northward. On interannual timescale, the number of C1 TCs is influenced by the intensity variability of the WNPSH, which is represented by the first Empirical Orthogonal Function (EOF) of 850 hPa geopotential height of the region. The WNPSH itself is modulated by the El Niño–Southern Oscillation at its peak phase in the previous winter, as well as Indian and Atlantic Ocean sea surface temperature anomalies in following seasons. The second EOF mode shows the interdecadal change of WNPSH intensity. The interdecadal variability of WNPSH intensity related to the Pacific climate regime shift could cause anomalies of the steering flow, and lead to the longitudinal shift of C1 TC track. Negative phases of interdecadal Pacific oscillation are associated with easterly anomaly of steering flow, westward shift of C1 TC track, and large TC impact on the East Asia coastal area.
Changes in forward light scatter parameters as a function of refractive error in young adults
Authors: Nagra Manbir , Patel Mansi , Barbur John 
Published: January 2020

Abstract
Background/aims
Some aspects of visual performance worsen with increasing myopia. Whilst the underlying causes are not always clear, reduction in retinal image quality is often attributed to structural changes in the posterior myopic eye. Forward light scatter, originating principally from the cornea and lens, is known to produce veiling glare which subsequently reduces retinal image contrast. It is therefore of interest to investigate whether forward light scatter varies with refractive error.

Methods
Thirteen young-adult subjects (18–25 years), with mean spherical errors (MSE ± sd, D) RE, − 1.69 ± 2.02 (range 0.38 to − 4.75); LE, − 1.91 ± 1.94 (range 0.50 to − 4.63) underwent binocular assessment of forward light scatter using the AVOT light scatter test. Five glare annuli, with effective eccentricities ranging from 2 to 10°, were used to estimate parameters, k and n, which define the light scatter function of the eye. These were then used to calculate the area under the light scatter function (k′) and the total volume of light scatter (k″).

Results
Significant correlation was found between increasing myopia and k′ values (RE, p < 0.05; r = 0.64; LE, p < 0.05, r = 0.66). Neither the ‘volume’ of light scatter (k″), the parameter, n, which controls the angular distribution of light scatter, or the straylight parameter constant, k, were significantly correlated with refractive error (p > 0.05 for both eyes). Axial length was also not correlated with any of the light scatter parameters measured.

Conclusion
The preliminary data from this study provide evidence that some light scatter parameters may be correlated with refractive error. Further studies are needed to characterize how changes in the anterior media of the eye, and inclusion of a wider range of refractive errors, may affect forward light scatter.