bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing Serine as Cardiovascular Disease Biomarker Candidate via Pathway Analysis
Authors: Rezaei Tavirani Mostafa , Zamanian Azodi Mona , Rostami-Nejad Mohammad , Morravej Hamideh , Razzaghi Zahra , Okhovatian Farshad , Rezaei-Tavirani Majid 
Published: March 2020

Background: The rate of death due to cardiovascular disease (CVD) is growing. Investigations about CVD that leading to introduce varieties of metabolites is available. The monitoring of these metabolites to find effective ones in the future of clinic applications is the main aim of this study. Materials and Methods: Numbers of 34 metabolites for the CVD are extracted from literature and designated for interaction determinations by MetScape V 3.1.3. The compound-reaction-enzyme-gene network was constructed and the pathways were analyzed. Based on the presence of metabolites in the pathways the critical compounds were determined. Results: Pathway analysis revealed 18 disturbed pathways related to the CVD. glycerophospholipid metabolism pathway including 27 compounds is related to the 9 queried metabolites. L-Serine which was communed between 5 pathways and also was presented in the largest pathway was identified as the critical compound. Conclusion: It can be concluded that L-Serine is a proper biomarker candidate for CVD diagnosis and also patients follow up approaches. [GMJ.2020;9:e1696]
Desarrollo vs. satisfacción de necesidades básicas
Authors: Pardo Montaño Ana Melisa , Dávila Cervantes Claudio Alberto 
Published: March 2020

*Full article is in SpanishEnglish abstract: This article responds to the following questions: Which sociodemographic characteristics of households influence the reception of remittances in Morelos? What are the differences in household expenditure in basic needs if a household receives internal or international remittances, or if it receives none? Using the National Income and Expenditure Survey of 2016, we employed a logistic regression to examine the factors associated with the reception of remittances, and we analyzed different areas of expenditure by type of household. We present some reflection on a sending community in Morelos (Axochiapan) where we conducted 23 semi-structured interviews with people who receive remittances, who explained the main uses of these resources. We observed household characteristics that favor the reception of remittances, mainly used to satisfy basic needs.Spanish abstract: Este artículo buscó responder: ¿qué características socio-demográficas en hogares influyen en la recepción de remesas en Morelos? y ¿cuáles son las diferencias en el gasto de los hogares respecto a sus necesidades básicas recibiendo o no remesas internas o internacionales? Utilizando la Encuesta Nacional de Ingresos y Gastos de los Hogares 2016, estimamos una regresión logística para examinar los factores asociados a la recepción de remesas y analizamos los rubros del gasto por tipo de hogar. Presentamos opiniones de una comunidad de origen en Morelos (Axochiapan), donde realizamos 23 entrevistas semiestructuradas a personas receptoras de remesas, quienes explicaron los principales usos de estos recursos. Observamos características de los hogares que favorecen la recepción de remesas, mayormente ocupadas en la satisfacción de necesidades básicas.French abstract: Cet article pose la question suivante: quelles caractéristiques sociodémographiques des ménages influencent les transferts de fonds au Morelos? Quelles sont les différences de dépenses des ménages quant à leurs besoins fondamentaux, en fonction des transferts de fonds internes ou internationaux? A partir de l’Enquête nationale sur les revenus et dépenses de 2016, nous avons réalisé une régression logistique afin d’analyser les facteurs associés à la réception de fonds et les types de dépenses selon les ménages. Nous présentons ici les résultats concernant une communauté originaire du Morelos (Axochiapan), où nous avons effectué vingt-trois entretiens semi-structurés avec des destinataires de fonds qui ont expliqué les principales utilisations qu’ils faisaient de ces revenus. Nous en concluons les caractéristiques des ménages qui favorisent la réception des transferts de fonds, destinés principalement à satisfaire des besoins fondamentaux.
Conceptualizing sub-national regional cooperation
Authors: Morales Diana 
Published: March 2020

English abstract:
Regional cooperation is a context-dependent process that is better understood using a geographical approach; this is, accounting for the region as part of the explanation for and not only as the container in which cooperative agreements operate. The case of the Coffee Cultural Landscape of Colombia, a bottom-up regional cooperation process that resulted in a regional trademark, illustrates what roles are played by a diversity of local actors and how local socio-economic conditions influence cooperation agreements. The case highlights the inadequacy of inflexible jurisdictional boundaries and the limitations of preexisting categories (such as inter-municipal cooperation or metropolitan areas). The empirical evidence includes the analysis of 19 semi-structured interviews.Spanish abstract:
La cooperación regional es un proceso que depende del contexto local y regional; y una perspectiva geográfica apoya a considerar la región donde ocurre como parte de la explicación, y no como un contenedor dentro del cual operan los acuerdos. Este artículo aborda el caso del Paisaje Cultural Cafetero Colombiano, un proceso de cooperación regional de abajo hacia arriba que resultó en una marca registrada regional. El caso ilustra participantes y roles en el proceso y cómo las condiciones socioeconómicas locales influyen en los acuerdos de cooperación. Los resultados destacan la inflexibilidad de las divisiones jurisdiccionales y las limitaciones de las categorías preexistentes (como la cooperación intermunicipal o las áreas metropolitanas). La metodología incluyó el análisis de 19 entrevistas semi-estructuradas.French abstract:
Les processus de coopération régionale dépendent de leur contexte et sont mieux appréhendés à travers une approche géographique. En d’autres termes, il est nécessaire de prendre en compte la région comme partie intégrante de l’analyse, et non uniquement en tant que simple structure où les accords de coopérations se déroulent. Le cas du Paysage culturel du café de Colombie, un processus de coopération régionale du bas vers le haut qui a abouti à la création d’une marque, illustre les rôles joués par une diversité d’acteurs locaux et comment les conditions socio-économiques influencent les accords de coopération. Il met en évidence l’inadéquation des frontières juridictionnelles inflexibles et les limites des catégories préexistantes (comme la coopération inter-municipale et les aires métropolitaines). La méthodologie repose sur une étude de cas et dix-neuf entretiens semi-directifs.
Transtemporal approach to hypothalamic hamartomas in children: report of 3 cases
Authors: Silva Adikarige H. D. , Lo William B. , Mundil Nilesh R. , Walsh A. Richard 
Published: March 2020

The surgical approach to hypothalamic hamartomas (HHs) associated with medically refractory epilepsy is challenging because of these lesions’ deep midline or paramedian location. Whether the aim is resection or disconnection, the surgical corridor dictates how complete a procedure can be achieved. Here, the authors report a transtemporal approach suitable for Delalande type I, inferior extraventricular component of type III, and type IV lesions. This approach provides optimal visualization of the plane between the hamartoma and the hypothalamus with no manipulation to the pituitary stalk and brainstem, allowing for extensive disconnection while minimizing injury to adjacent neurovascular structures.Through a 1-cm corticectomy in the middle temporal gyrus, a surgical tract is developed under neuronavigational guidance toward the plane of intended disconnection. On reaching the mesial temporal pia-arachnoid margin, it is opened, providing direct visualization of the hamartoma, which is then disconnected or resected as indicated. Critical neurovascular structures are generally not exposed through this approach and are preserved if encountered.Three patients (mean age 4.9 years) with intractable epilepsy were treated using this technique as part of the national Children’s Epilepsy Surgery Service. Following resection, the patient in case 1 (Delalande type I) is seizure free off medication at 3 years’ follow-up (Engel class IA). The patient in case 2 (Delalande type III) initially underwent partial disconnection through a transcallosal interforniceal approach and at first had significant seizure improvement before the seizures worsened in frequency and type. Complete disconnection of the residual lesion was achieved using the transtemporal approach, rendering this patient seizure free off medication at 14 months postsurgery (Engel class IA). The patient in case 3 (Delalande type IV) underwent incomplete disconnection with a substantial reduction in seizure frequency at 3 years’ follow-up (Engel class IIIC). There were no surgical complications in any of the cases.The transtemporal approach is a safe and effective alternative to more conventional surgical approaches in managing HHs with intractable epilepsy.
Protocol-driven prevention of perioperative hypothermia in the pediatric neurosurgical population
Authors: Mutchnick Ian , Thatikunta Meena , Braun Julianne , Bohn Martha , Polivka Barbara , Daniels Michael W. , Vickers-Smith Rachel , Gump William , Moriarty Thomas 
Published: March 2020

OBJECTIVEPerioperative hypothermia (PH) is a preventable, pathological, and iatrogenic state that has been shown to result in increased surgical blood loss, increased surgical site infections, increased hospital length of stay, and patient discomfort. Maintenance of normothermia is recommended by multiple surgical quality organizations; however, no group yet provides an ergonomic, evidence-based protocol to reduce PH for pediatric neurosurgery patients. The authors’ aim was to evaluate the efficacy of a PH prevention protocol in the pediatric neurosurgery population.METHODSA prospective, nonrandomized study of 120 pediatric neurosurgery patients was performed. Thirty-eight patients received targeted warming interventions throughout their perioperative phases of care (warming group—WG). The remaining 82 patients received no extra warming care during their perioperative period (control group—CG). Patients were well matched for age, sex, and preparation time intraoperatively. Hypothermia was defined as < 36°C. The primary outcome of the study was maintenance of normothermia preoperatively, intraoperatively, and postoperatively.RESULTSWG patients were significantly warmer on arrival to the operating room (OR) and were 60% less likely to develop PH (p < 0.001). Preoperative forced air warmer use both reduced the risk of PH at time 0 intraoperatively and significantly reduced the risk of any PH intraoperatively (p < 0.001). All patients, regardless of group, experienced a drop in core temperature until a nadir occurred at 30 minutes intraoperatively for the WG and 45 minutes for the CG. At every time interval, from preoperatively to 120 minutes intraoperatively, CG patients were between 2 and 3 times more likely to experience PH (p < 0.001). All patients were warm on arrival to the postanesthesia care unit regardless of patient group.CONCLUSIONSPreoperative forced air warmer use significantly increases the average intraoperative time 0 temperature, helping to prevent a fall into PH at the intraoperative nadir. Intraoperatively, a strictly and consistently applied warming protocol made intraoperative hypothermia significantly less likely as well as less severe when it did occur. Implementation of a warming protocol necessitated only limited resources and an OR culture change, and was well tolerated by OR staff.
Assessing the differences in characteristics of patients lost to follow-up at 2 years: results from the Quality Outcomes Database study on outcomes of surgery for grade I spondylolisthesis
Authors: Bisson Erica F. , Mummaneni Praveen V. , Knightly John , Alvi Mohammed Ali , Goyal Anshit , Chan Andrew K. , Guan Jian , Biase Michael , Strauss Andrea , Glassman Steven , Foley Kevin , Slotkin Jonathan R. , Potts Eric , Shaffrey Mark , Shaffrey Christopher I. , Haid Regis W. , Fu Kai-Ming , Wang Michael Y. , Park Paul , Asher Anthony L. , Bydon Mohamad 
Published: March 2020

OBJECTIVELoss to follow-up has been shown to bias outcomes assessment among studies utilizing clinical registries. Here, the authors analyzed patients enrolled in a national surgical registry and compared the baseline characteristics of patients captured with those lost to follow-up at 2 years.METHODSThe authors queried the Quality Outcomes Database for patients with grade I lumbar degenerative spondylolisthesis undergoing a surgical intervention between July 2014 and June 2016. Only those patients enrolled in a multisite study investigating the impact of fusion on clinical and patient-reported outcomes (PROs) among patients with grade I spondylolisthesis were evaluated.RESULTSOf the 608 patients enrolled in the study undergoing 1- or 2-level decompression (23.0%, n = 140) or 1-level fusion (77.0%, n = 468), 14.5% (n = 88) were lost to follow-up at 2 years. Patients who were lost to follow-up were more likely to be younger (59.6 ± 13.5 vs 62.6 ± 11.7 years, p = 0.031), be employed (unemployment rate: 53.3% [n = 277] for successful follow-up vs 40.9% [n = 36] for those lost to follow-up, p = 0.017), have anxiety (26.1% [n = 23] vs 16.3% [n = 85], p = 0.026), have higher back pain scores (7.4 ± 2.9 vs 6.6 ± 2.8, p = 0.010), have higher leg pain scores (7.4 ± 2.5 vs 6.4 ± 2.9, p = 0.003), have higher Oswestry Disability Index scores (50.8 ± 18.7 vs 46 ± 16.8, p = 0.018), and have lower EQ-5D scores (0.481 ± 0.2 vs 0.547 ± 0.2, p = 0.012) at baseline.CONCLUSIONSTo execute future, high-quality studies, it is important to identify patients undergoing surgery for spondylolisthesis who might be lost to follow-up. In a large, prospective registry, the authors found that those lost to follow-up were more likely to be younger, be employed, have anxiety disorder, and have worse PRO scores.
EXPERIMENTAL RESEARCH OF FIRES IN GRASSY ECOSYSTEMS
Authors: Kuzyk A. , Tovaryanskyi V. , Drach K. 
Published: March 2020

Formulation of the problem. The fire hazard of grass ecosystems depends on many factors that determine the proper condition of the combustible material and support the burning process. The most important indicators of danger are the condition and humidity of grass. The main external factors of influence on the occurrence and spread of fires in natural ecosystems are: air temperature and air relative humidity, precipitation, wind speed. The urgent task is to determine the rate of spread of fires in grassy ecosystems.
The purpose of this work is to establish the features of occurrence and spread out of grass fires in the forest-steppe conditions of Ukraine on the basis of fire hazard analysis and experimental studies.
Research methods. The studies were conducted in the forest-steppe zone in the Vinnytsia region on November 1-3, 2019. The plots with 10 m in length and 3 m in width were chosen, taking into account the wind direction along the plot. During the studies, the wind speed was in a range of 0 to 10 meters per second, the air temperature varied from 7 to 14 Celsium degrees during the day and from -3 to 12 Celsium degrees at night. The air humidity varied from 52 to 69 per cent during the day and from 72 to 84 per cent at night. The humidity of the grass was 20-22 per cent in the daytime, and 27-30 per cent at night. The fire load on the sites was 4-5 t/ha.
The main results of the study. Combustion mostly did not happen since 19 p.m. till 10 a.m. because the grass cover during the night increased the moisture content due to the relative humidity increasing and drop of temperature. After 10 a.m. in clear conditions and in the presence of wind, the humidity of the grasses decreased, which facilitated their ignition and spread of fire. However, in the absence of wind, ignition did not happen.
The fire spreading rate depended on wind speed and grass height. For grasses 40 cm high the fire spread rate was from 2.5 m/min (wind speed 1-2 m/s) to 3.5 m/min (wind speed 6-8 m/s). For grasses 60 cm high the fire spread rate was from 3.1 m/min (wind speed 1-2 m/s) to 12.5 m/min (wind speed 6-8 m/s).
Conclusions. The rate of fire spread in grassу ecosystems depend on temperature and relative humidity, wind speed, grass humidity, height and spatial location. At night, the high humidity of grasses, caused by high relative humidity and low air temperature, hinders ignition and burning, but the fire may occur in the presence of wind in the presence of several sources of ignition with sufficient energy.
Soviet Musical Avant-Garde in the Context of Time (in the mid. 1950s – 1980s): Historical and Cultural Studies and Philosophical Aspects
Authors: Andreeva O. V. 
Published: March 2020

Introduction. Interest in the work of avant-garde artists does not wane as they move away from the 20th century. This is due to the fact that the musical avant-garde, becoming a sign of the time, reflected the most important trends of the outgoing era. In the paper, the Soviet musical avant-garde is considered in the historical, cultural and philosophical aspect in the context of the historical era, which determines the novelty of the study. An aspect of novelty is the analysis of music as a sphere of intercultural communication.Methodology and sources. The research methodology is based on the analysis of sources and literature, taking into account interdisciplinary approaches. A special role in the understanding of the theoretical aspects of the problem play the work of musicologists Yu. N. Kholopova, V. N. Kholopova, V. S. Price, R. L. Pospelova, A. I. Demchenko. Among the sources highlighted in cinema, photo- and phonodocuments, which depicts a vivid image of the era. The interviews with composers, which presents a wide canvas of social and musical life (A. Schnittke, A. Ivashkina entry and volkonskii, recording E. Dubinets) are of considerable interest. Historical, comparative, systematic and semiotic methods of analysis were used. Applies a comprehensive approach (formation and civilization methods of research and the Annales school). This allows for a new approach to the historical era of the middle1950s – 1980s.Results and discussion. Postwar culture is examined as a single space, in which a special role was played by the impulses of the “thaw”. They gave cultural phenomena such inertial dynamics, which preserves the spiritual maturity of society and produced changes of the 1990s, the results of the study show that in contrast to the political and socio-economic processes, cultural life in these years continued to feel the pulses of the “thaw”. Retaining the inertial dynamics of development, cultural processes have been far from stagnation, which casts doubt on the overall rating this time as the “era of stagnation”. This allows you to put a discussion question on the revision of the political clichés in relation to the period of the middle 1960s – 1980s in the Soviet Union as the “era of stagnation”.Conclusion. Soviet avant-garde, expressing the spirit of the time, represents the unique phenomenon in which reflected global trends, and the uniqueness of national culture. Experience avant-garde shows that cultural processes of the epoch middle 1950s – 1980s had a high development dynamics. The study of this period, especially in its spiritual sphere, requires interdisciplinary approaches and the use of modern, including foreign methods. Interest methods of the Annales school in its historical retrospect and the “new cultural history”.
Perlakuan Invigorasi Pada Benih Padi Di Kelompok Tani Pelita Desa Noepesu
Authors: Tefa Anna 
Published: March 2020

Abstrak
Penyimpanan benih dapat mengakibatkan turunnya kemampuan benih untuk menjadi bibit yang vigor. Salah satu cara yang dapat dilakukan sebelum tanam untuk memperbaiki performa benih adalah perlakuan invigorasi dengan matriconditioning (conditioning dengan menggunakan media padat lembab) pada benih. Tujuan pengabdian ini adalah petani mitra menguasai vigor dan viabilitas benih yang digunakan untuk pembibitan, mitra dapat mengetahui dan mampu melakukan invigorasi pada benih padi untuk meningkatkan daya berkecambah, kecepatan pertumbuhan, keserempakan tumbuh dan mengurangi benih yang tumbuh abnormal pada saat persemaian. Penelitian ini dilaksanakan di kelompok Tani Pelita Desa Noepesu Kabupaten Timor Tengah Utara dengan metode pelatihan dan praktek langsung di Lahan sawah petani. Hasil yang diperoleh menunjukkan bahwa animo masyarakat untuk mengikuti pelatihan ini sangat besar. Benih padi yang digunakan untuk persemaian tumbuh lebih cepat yaitu 5 hari setelah semai sudah tumbuh normal, pertumbuhannya seragam dan memiliki daya berkecambah yang tinggi.
Penanaman Mangrove Di Perairan Pantai Tanjung Bastian
Authors: Ledheng Ludgardis , Yustiningsih Maria 
Published: March 2020

Hutan mangrove Pantai Tanjung Bastian memiliki luas lebih kurang 37 ha. Jumlah tersebut mengalami penurunan dari tahun ke tahun (Anonimous, 2005). Hal ini disebabkan karena banyaknya pemanfaatan hutan mangrove untuk berbagai keperluan diantaranya areal pertambakan, keperluan pemenuhan kayu bakar dan bahan bangunan untuk kepentingan sendiri dan komersial, infrastruktur pantai termasuk pelabuhan, pembangunan tempat perdagangan dan perumahan, pengembangan pariwisata yaitu wisata alam serta pertanian. Berbagai aktivitas yang terjadi pada hutan mangrove Tanjung Bastian memberikan dampak kurang baik terhadap vegetasi, di antaranya terjadi perubahan komposisi dan struktur vegetasi pada berbagai tingkat pertumbuhan seperti anakan, pancang, tiang, dan pohon. Tujuan kegiatan pengabdian ini adalah: 1) Pemberdayaan masyarakat untuk selayaknya menjaga populasi mangrove yang ada di pesisir pantai tanjung Bastian. 2) Menumbuhkan kesadaran dan motivasi bagi masyarakat pesisir untuk menanam kembali mangrove sebagai bentuk kepedulian terhadap lingkungan pesisir. Metode kegiatan yang digunakan dalam kegiatan ini adalah penyuluhan dan pendampingan penanaman mangrove. Hasil kegiatan yang didapat bahwa setelah dilakukan penyuluhan tentang potensi dan bahaya kerusakan ekosistim mangrove, masyarakat merasa sangat antusias melakukan penanaman bersama. Dampak dari kegiatan ini adalah mulai ditanamnya manggrove khusunya pada areal tambak.
Aplikasi Teknologi Fermentasi Jerami Padi Sebagai Sumber Pakan Alternatif Ternak Sapi Bali Untuk Mengatasi Kekurangan Pakan Di Kelompok Tani Nek’to Noapala Desa Kiuola Kecamatan Noemuti Kabupaten TTU
Authors: Nahak Oktovianus R , Kolo Maria Magdalena , Sikone Hilarius Y 
Published: March 2020

Kelompok Tani Nek’To Noapala terletak di Desa Kiuola Kecamatan Noemuti Kabupaten Timor Tengah Utara. Desa ini memiliki beberapa potensi pertanian dan peternakan yang dapat dikembangkan oleh petani, salah satunya tanaman padi (Oriza sativa L.) dan hasil ikutan dari tanaman padi tersebut dimanfaatkan untuk produktivitas ternak sapi. Jerami padi merupakan limbah dari tanaman padi sebagai pakan ternak memiliki kadar protein rendah, berserat tinggi dan berdaya cerna rendah sehingga diperlukan adanya suatu perlakuan yaitu dengan teknologi fermentasi. Metode yang dipakai dalam kegiatan pengabdian ini berupa FGD( Foccus Discussion Group) dan praktek secara langsung. Proses fermentasi dilakukan dengan dua tahap yaitu tahap fermentasi dan pengeringan. Proses fermentasi berlangsung selama 21 hari secara anaerob. Hasil yang diperoleh yaitu jerami padi hasil fermentasi yang memiliki kualitas fisik cukup baik diantaranya memiliki tekstur yang lembut, warna kuning kecoklatan dan aroma seperti tapeserta hasilnya langsung diaplikasikan ke ternak sapi. Disimpulkan bahwa kegiatan pengabdian ini dapat meningkatkan pengetahuan dan keterampilan masyarakat terkhususnya anggota kelompok tani Nek’To Noapala Desa Kiuola tentang pemanfaatan jerami padi secara fermentasi sebagai pakan alternatif bagi ternak sapi