bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between delivery mode and postpartum depression: a systematic review and meta-analysis
Authors: Chen Yu-Xin , Zhao Pei , Jiesisibieke ZhuLiduzi , Chen Pei-En , Tung Tao-Hsin , Chien Ching-Wen 
Published: May 2020

Abstract
Background: To assess the relationship between delivery mode and postpartum depression and to examine whether cesarean section (CS) has a higher risk of postpartum depression than vaginal delivery (VD). Methods: We searched the Cochrane Library, PubMed, and EMBASE from inception to 30 April 2019 without language limitations. Two authors independently selected studies, assessed the quality of included studies, and extracted data. Any disagreements were resolved by discussion with a third author. We used the Newcastle-Ottawa Scale and GRADE methods to assess the quality of the included studies and evidences. This study had four included cohort studies data and carried out fixed-effect model meta-analysis. Results: The findings demonstrated a significant difference in the risk of postpartum depression between CS and VD. Compared with the control group, the CS group was associated with a higher prevalence of postpartum depression symptoms (Risk Ratio =1.29; 95% CI: 1.11-1.51). Conclusions: The findings supported a relationship between delivery mode and postpartum depression. Particularly, we found that CS is associated with a higher risk of postpartum depression. Therefore, we ought to encourage pregnant women who are without medical indication of CS to select VD.r Trial registration: The protocol of this systematic review was registered in the PROSPERO under the number CRD42019148154.
Acteoside counteracts interleukin-1β-induced catabolic processes through the modulation of mitogen-activated protein kinases and the NFκB cellular signaling pathway
Authors: Lim HyangI , Kim Do Kyung , Kim Tae-Hyeon , Kang Kyeong-Rok , Seo Jeong-Yeon , Cho Sung Sik , Yun Younghee , Choi Ye-yong , Leem Jungtae , Kim Hyoun-Woo , Cho Geon-Ung , Oh Chan-Jin , Oh Deuk-Sil , Chun Hong-Sung , kim jae-sung 
Published: May 2020

Abstract
Objectives

To verify the anti-catabolic effects of acteoside [α-L-rhamnosyl-(1->3)-β-D-glucoside] against osteoarthritis and its anti-catabolic signaling pathway.
Methods

Primary rat chondrocytes were isolated enzymatically from the articular cartilage of rat knee joint. Cytotoxicity of acteoside was assessed by MTT and Cell Live/Dead assay. Proteoglycan content was measured by dimethylmethylene blue assay. The proteoglycan loss was assessed by histological analysis using safranin-O & fast green staining after ex vivo organ culture of articular cartilage. The alteration of catabolic factors such as cartilage degrading enzymes, pro-inflammation cytokines, and inflammatory mediators were assessed by qPCR, qRT-PCR, gelatin zymography, western blot, and cytokine array. Cellular signaling pathways were investigated by western blot and nucleus translocation. Acteoside was orally administrated to osteoarthritic animals generated by the destabilization of medial meniscus at the knee joint of mice for 8 weeks. Thereafter, proteoglycan loss was assessed by safranin-O & fast green staining.
Results

Acteoside did not decrease the viabilities of mouse fibroblast L929 cells used as a normal cells and primary rat chondrocytes. Acteoside counteracted the IL-1β-induced proteoglycan loss in the chondrocytes and articular cartilage through suppressing the expression and activation of cartilage-degrading enzyme such as matrix metalloproteinase (MMP)-13, MMP-1, and MMP-3. Furthermore, acteoside suppressed the expression of inflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, nitric oxide, and prostaglandin E2 in the primary rat chondrocytes treated with IL-1β. Subsequently, the expression of pro-inflammatory cytokines was decreased by acteoside in the primary rat chondrocytes treated with IL-1β. Moreover, acteoside suppressed not only the phosphorylation of mitogen-activated protein kinases in primary rat chondrocytes treated with IL-1β but also the translocation of NFκB from the cytosol to the nucleus through suppression of its phosphorylation. Oral administration of 5 and 10 mg/kg acteoside attenuated the progressive degeneration of articular cartilage in the osteoarthritic mouse model generated by destabilization of the medial meniscus.
Conclusion

Our findings indicate that acteoside is a promising potential anti-catabolic agent or supplement to attenuate or prevent progressive degeneration of articular cartilage.
A decline and age shift in malaria incidence in rural Mali following implementation of seasonal malaria chemoprevention and indoor residual spraying
Authors: Coulibaly Drissa , Guindo Boureima , Niangaly Amadou , Maiga Fayçal , Konate Salimata , Kodio Aly , Diallo Astou , Antar Abdou Tahirou Mohamed , Kone Abdoulaye K , Traore Karim , Travassos Mark , Doumbo Ogobara K , Thera Mahamadou A 
Published: May 2020

Abstract
BackgroundDeclines in malaria incidence attributed to the implementation of control strategies have been reported in many African countries. The declines are often accompanied by a shift in clinical burden to older children. In Mali, artemisinin-based combination therapy (ACT) was introduced in 2004, and Long-lasting insecticide-treated nets (LLINs) have been partially distributed free of charge since 2007. In Bandiagara, a study conducted from 2009 to 2013 showed a stable incidence of malaria compared to 1999 despite the use of ACTs and LLINs. Since 2016, seasonal malaria chemoprevention (SMC) has been scaled up across the country. In addition to these strategies, the population of Bandiagara benefited the universal bed net coverage and indoor residual spray (IRS) implementation in 2017 and 2018.This study aimed to measure the incidence of malaria in the context of recent scaling-up of control strategies.MethodsA cohort of 300 children aged 6 months to 15 years was followed from October 2017 to December 2018 in Mali. Monthly cross-sectional surveys were done to measure the prevalence of malaria infection by microscopy and anaemia. The study outcomes included the monthly prevalence of malaria infection and the incidence of symptomatic malaria.ResultsThe incidence of symptomatic malaria was 0.5 episodes/person-year. The average prevalence of malaria parasitaemia was 6.7%. The incidence was higher in the oldest age group than the youngest one (0.6 episodes/person-year in children above 10 years vs 0.29 in 6 months to 5 years age group).ConclusionsThis study showed a reduction of malaria incidence compared to 1999 and 2009-2013. An age shift in the susceptibility to malaria was also observed; older children experienced more clinical malaria than younger ones. These findings suggest to extend malaria control efforts to older children.
Incidental 18F-FDG PET/CT finding of COVID-1 pneumonia in asymptomatic patient diagnosed with lung abscess metastasis
Authors: Mestre-Fusco Antoni , Velasco-Nuño Mònica , Negre-Busó Montserrat , Ferran Núria , Juanpere Sergi , Rubió Antoni 
Published: May 2020

Abstract
A 66-year-old male patient, with chronic respiratory disease and right colon resection in March 2017 for colon low-grade adenocarcinoma was assessed for recurrence suggested by elevated levels of tumor marker and no evidence of oncological disease by CT scan. 18F-FDG PET/CT showed bilateral multiple peripheral FDG-avid foci that matched with a peripheral predominant ground-glass opacities (GGOs) observed in lower lobes and multiple FDG-positive enlarged lymph nodes were also identified in the mediastinum. Patient was hospitalized in March 14th 2020, one day after PET/CT scan, with cough, wheezing and fever, and was treated with anti-inflammatory drugs. A first SARS-CoV-2 RT-PCR in March 15th resulted as negative and patient was treated with antibiotic therapy lead to an improvement of respiratory symptoms. PET/CT scan was interpreted as a pneumonia foci. A deteriorating patient condition was observed, with respiratory symptomatology progression, fatigue and D-Dimer elevation and a new RT-PCR resulted positive. A week after PET/CT scan, hospitalization in intensive care unit was necessary for rapidly disease progression and severe respiratory distress syndrome and patient died four days later.
How to conduct post-graduate training of general practitioners in performing articular or abarticular corticosteroid injections in the knee and shoulder joints? Analysis of the current training courses, literature review and implementation of a new training program
Authors: Vrignaud Arthur , Dernis Emmanuelle 
Published: May 2020

Abstract
Background: While several studies have shown the usefulness and effectiveness of articular and abarticular corticosteroid injections performed by general practitioners, the main limitation that has been identified in expanding the use of these acts in everyday practice lies in a lack of training. Thus, this study aimed to determine the best settings for training courses concerning this subject.Methods: Our study was composed of two parts: the first one consisted in a survey concerning the improvements induced by training courses in the context of continuing medical education on the participants’ skills and degree of confidence, the second part was a review of the published literature about this topic.Results: As expected, every training program analysed through our survey generated improvements in the participants’ confidence in performing articular or abarticular injections. Furthermore, these findings are reflected in an increase in the proportion of such skills that the trainees complete by themselves. These results were reinforced by similar findings raised by the literature review. Moreover, it highlighted that hands-on training courses seemed to be the most efficient and that the use of synthetic models appeared to be a suitable alternative to human bodies or corpses, surrounded by less ethical and logistic concerns.Conclusion: This study supports the expansion of training courses for general practitioners on articular and abarticular injections. It also suggests that they should be based on a hands-on training design, possibly with the use of manikins.
Magnitude and Performance of Percentage Body Fat and Fat Mass Index in Determining Overweight/Obesity among University Undergraduate Students in the Kumasi Metropolis, Ghana.&nbsp;
Authors: Obirikorang Christian , Acheampong Emmanuel , Anto Enoch Odame , Obirikorang Yaa , Fynn Angela Nana Bosowah , Osei-Somuah George , Amoah Brodrick Yeboah , Busumbru Eunice Adwubi , Appiah Michael , Adu Evans Asamoah , Acheampng Emmanuella Nsenbah , Gyamfi Daniel 
Published: May 2020

Abstract
Background: Anthropometric indices such as body mass index (BMI) is a widely used index of adiposity across clinical settings, yet there are limitations regarding their estimates of body fat. We determined the magnitude and the performance of fat mass index (FMI), and percentage body fat (PBF) for determining obesity among undergraduate students in the Kumasi Metropolis, Ghana. Methods: This University community-based cross-sectional study included 1,552 undergraduate students (700 males and 852 females) aged 15–29 years from the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Anthropometric measurements and bioelectrical impedance analyses were performed. Data on sociodemographic and lifestyle-related characteristics were obtained using a structured questionnaire. Results: Comparing male to female students, the age-standardised prevalence of overweight/obesity was 10.8%/3.5% vs. 19.3%/7.6% (p<0.0001) for BMI criterion, 16.4%/8.5% vs. 21.9%/19.9% (p<0.0001) for PBF criterion and 16.0%/9.2 vs. 21.2%/22.0% for FMI criterion (p<0.0001), respectively. There was a stronger agreement between PBF and FMI in the classification of overweight and obesity in terms of males (kappa=0.855) and females (kappa=0.865) but a weak agreement between BMI and PBF and between BMI and FMI. About 29.3% of males and 61.4% of the females categorized as normal weight by BMI were identified as overweight by PBF. Similarly, 3.0% of male and 1.3% of females defined as normal weight by BMI were obese when examined by PBF. FMI can be predicted from BMI and BMI2 with much accuracy (mean bias = -0.1). Conclusion: The inconsistency observed between BMI and PBF reflects a limitation of BMI. FMI accurately assessed obesity with many conveniences as BMI to the same extent.
A new statistical approach to model the counts of novel coronavirus cases
Authors: El-Morshedy M. , Altun Emrah , Eliwa M. S. 
Published: May 2020

Abstract
This study proposes new statistical tools to analyze the counts of the daily coronavirus cases and deaths. Since the daily new cases and deaths exhibit highly overdispersion, we introduce a new two-parameter discrete distribution, called \textit{discrete generalized Lindley}, which enables us to model all kinds of dispersion such as under, equi and overdispersion. Additionally, we introduce a new count regression model based on the proposed distribution to investigate the effects of the important risk factors on the counts of deaths for OECD countries. Three data sets are analyzed with proposed models and competitive models. Empirical findings show that air pollution, the proportion of obesity, and smokers in a population do not affect the counts of deaths for OECD countries. The interesting empirical result is that the countries with having larger alcohol consumption have lower counts of deaths.
In-situ fixed bed denitrification in sequential biofiltration: laboratory testing of solid substrates
Authors: Filter Josefine , Bosinsky Christin , Kilinc Sefine Oksal , Ruhl Aki Sebastian , Jekel Martin 
Published: May 2020

Abstract
High nitrate concentrations in wastewater treatment plant effluents and aquifers can challenge sequential biofiltration systems in preventing nitrite and gas formation in the sand bed, as well as to achieve the regulated limit value for nitrate in potable water reuse applications. This study investigates the introduction of electron donors in the form of organic fixed bed materials as an in-situ anoxic zone into sequential biofiltration systems. Laboratory batch and column tests with straw, soft wood, peat, polylactic acid (PLA), and polycaprolacton (PCL) revealed incomplete denitrification with a hydraulic retention time below 10 h, high organic carbon leaching, especially during the first three months, and gas accumulation within the filter bed. Therefore, ex-situ denitrification prior to oxic biofilters or in a defined side-stream treatment is recommended. No enhanced transformation of trace organic chemicals was observed under nitrate reducing conditions. Peat revealed a sorption potential for 5-methyl-benzotriazole, carbamazepine, benzotriazole, and metoprolol.
Occurrence of cyanobacteria, actinomycetes, and geosmin in drinking water reservoir in Korea: a case study from an algal bloom in 2012
Authors: Lee Jung Eun , Youn Seok-Jae , Byeon Myeongseop , Yu Soon-Ju 
Published: May 2020

Abstract
In 2012, a large concentration of geosmin was found in the Paldang reservoir, which is the primary source of drinking water in Seoul, Korea. In June and September 2012, we measured the concentrations of cyanobacteria and actinomycetes, and geosmin, to identify the source of geosmin in the Paldang reservoir. A total of 68 water samples were collected from two sampling sites (Sambong, Paldang), and used to analyze the correlation between cyanobacteria, actinomycetes, and geosmin. The cell density attained a maximum of 24,722 cells/mL on August 11, 2012 and geosmin occurred at a high concentration of 3,934 ng/L on August 13 in Sambong. After July 31, 2012 a rapid increase in growth and cell density occurred with a peak value of 11,568 cells/mL on August 6, 2012. At the same time, the geosmin concentration increased to 3,157 ng/L in Paldang. The number of cyanobacteria positively correlated with geosmin concentration (R2 = 0.84, P &lt; 0.0001), while actinomycetes were not significantly correlated with geosmin (R2 = 0.01, P = 0.709). In addition, the number of actinomycetes was associated with increased turbidity (R = 0.507). Among the various water quality constituents, temperature affected cyanobacteria in the Paldang reservoir (R = 0.803). These results suggest that cyanobacteria are the main source of geosmin in the Paldang reservoir, which might be providing useful information for managing the unpleasant taste of its drinking water.
Prediction of nitrate concentration in Danube River water by using artificial neural networks
Authors: Stamenković Lidija J. , Mrazovac Kurilić Sanja , Presburger Ulniković Vladanka 
Published: May 2020

Abstract
This paper describes the development of a model based on artificial neural networks (ANN) which aims to predict the concentration of nitrates in river water. Another 26 water quality parameters were also monitored and used as input parameters. The models were trained and tested with data from ten monitoring stations on the Danube River, located in its course through Serbia, for the period from 2011 to 2016. Multilayer perceptron (MLP), standard three-layer network is used to develop models and two input variable selection techniques are used to reduce the number of input variables. The obtained results have shown the ability of ANN to predict the nitrate concentration in both developed models with a value of mean absolute error of 0.53 and 0.42 mg/L for the test data. Also, the application of IVS has contributed to reduce the number of input variables and to increase the performance of the model, especially in the case of variance inflation factor (VIF) analysis where the estimation of multicollinearity among variables and the elimination of excessive variables significantly influenced the prediction abilities of the ANN model, r – 0.91.
Application of Fe2O3/ZrO2 loaded polyhedron ball on photocatalytic degradation of diesel pollutants in seawater under visible light
Authors: Wang Liping , Yu Xiaocai , Liao Jiaqi , Xue Bining , Tian Siyao , Zhu Wanting 
Published: May 2020

Abstract
Fe2O3/ZrO2 nanocomposite photocatalyst was successfully prepared by coprecipitation method for the degradation of diesel pollutants in seawater under visible light. The effects of doping ratio, calcination temperature, photocatalyst dosage, initial diesel concentration, H2O2 concentration, and reaction time on the photocatalytic removal efficiency were investigated. Moreover, the optimal conditions for Fe2O3/ZrO2 nanocomposite photocatalyst to degrade marine diesel pollution were determined. The removal efficiency of diesel by nanocomposite photocatalyst could reach 97.03%. A photocatalyst-loaded polypropylene polyhedral ball was prepared, and the removal efficiency of diesel by photocatalyst-loaded polypropylene polyhedral ball decreased from 99.35 to 68.84% after four recycling cycles.
Raman and Terahertz Spectroscopic Characterization of Solid-state Cocrystal Formation within Specific Active Pharmaceutical Ingredients
Authors: Du Yong , Xue Jiadan , Hong Zhi 
Published: May 2020

:
Cocrystallization of specific active pharmaceutical ingredients (APIs) in the solid-state phase is becoming
a feasible way to improve their corresponding physicochemical properties and ultimate bioavailability
without making and breaking any covalent bonds within them. Many recent reports deal with the characterization
and analysis topics of pharmaceutical APIs-based cocrystals. In this mini-review, we will focus on the recent
steady-state and time-dependent spectroscopic investigation into the cocrystallization of specific APIs based on
both Raman and emerging terahertz spectroscopy in pharmaceutical fields. Distinctive spectral, structural and
also kinetic information of pharmaceutical APIs-based cocrystals are obtained and discussed, which would
highlight the potential of vibrational spectroscopy as an attractive technique for various drug research and development
during cocrystallization of specific APIs.
Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line
Authors: Mo Fei , Luo Ya , Fan Dian , Zeng Hao , Zhao Yunuo , Luo Meng , Liu Xiaobei , Ma Xuelei 
Published: May 2020

Background:Caffeic Acid Phenethyl Ester (CAPE), an active extract of propolis, has recently been reported to have broad applications in various cancers. However, the effects of CAPE on Small Cell Lung Cancer (SCLC) are largely unknown. Therefore, the aim of this study was to determine the anti-proliferative effect of CAPE and explore the underlying molecular mechanisms in SCLC cells using high-throughput sequencing and bioinformatics analysis.Methods:Small-cell lung cancer H446 cells were treated with CAPE, and cell proliferation and apoptosis were then assessed. Additionally, the regulation mediated by miR-3960 after CAPE treatment was explored and the altered signaling pathways were predicted in a bioinformatics analysis.Results:CAPE significantly inhibited cell proliferation and induced apoptosis. CAPE decreased the expression of Yes-Associated Protein 1 (YAP1) and cellular myelocytomatosis oncogene (c-MYC) protein. Moreover, the upregulation of miR-3960 by CAPE contributed to CAPE-induced apoptosis. The knockdown of miR-3960 decreased the CAPE-induced apoptosis.Conclusion:We demonstrated the anti-cancer effect of CAPE in human SCLC cells and studied the mechanism by acquiring a comprehensive transcriptome profile of CAPE-treated cells.
Novel 2-(5-Aryl)thiophen-2-yl)benzimidazoles; Design, Synthesis and In vitro Evaluation Against Cercarial Phase of Schistosoma mansoni
Authors: El Bialy Serry Atta , Mansour Basem , Bayoumi Waleed Abdelhakeem , Taman Amira , Eissa Hassan Mohammed 
Published: May 2020

Background:
Literature survey has pointed out that Benzimidazoles represent an interesting
class of anthelmintics, of which several potent members were developed.

Objective:
Benzimidazoles hybridized with pharmacophoric moieties possessing anthelmintic activity
were designed, synthesized to be evaluated against cercaria.

Methods:
Structural modification was achieved through 2- and 5-positions. Moreover, an in vitro
cercarial assay was adopted to evaluate target compounds.

Results and Discussion:
Biological screening revealed that compound 3h showed significant activity
with a survival index of 35% at a 100 μg/mL concentration. Whereas, compounds 3a and 3c
showed moderate activity, the rest of the tested compounds exhibited low activity.

Conclusion:
The current study evidenced that the new hybrids "benzimidazole-thiophen-aryl" are
successful as cercacidal agents. Further studies of this novel tri-ring system are suggested on adult
worms of S. mansoni.