bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Resistance Training in the Treatment of Pre-Sarcopenia or Sarcopenia and Pre-Frailty or Frailty in Older People: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
Authors: Talar Karolina , Vetrovsky Tomas , Kalamacka Ewa , Steffl Michal 
Published: October 2019

Abstract
Background: Resistance training (RT) is considered as an effective method to increase muscle strength and physical performance in elderly people. Methods: A search from the earliest record up to and including June 2019 was carried out using the following electronic databases: PubMed, Scopus and Web of Science. The search strategy employed combined the terms related to the population (e.g. ‘sarcopenia’, ‘frailty’) with terms for the intervention (e.g. ‘resistance training’, ‘strength training’). Results: 11 studies including 2691 subjects were included in our meta-analysis (aged 64-98). Training duration ranged from 8 to 48 weeks and intensity up to 80% of 1-RM. According to the meta-analyses, RT had statistically significant effect on all the measures except handgrip strength. In handgrip strength Effect size (ES) was 0.58 (95 % CI: - 0.10 to 1.26) p = 0.076 with the moderate heterogeneity (I 2 = 58.6%). ES in legs strength was 0.52 (95 % CI 0.11 to 0.92) p = 0.022, I 2 = 42.0 %. The biggest ES was in TUG test where ES was 0.90 (95 % CI 0.19 to 1.60) p = 0.022, however, there was a high heterogeneity I 2 = 89.6. The high ES was found also in FFM 0.69 (95 % CI 0.17 to 1.20) p = 0.025, and gait speed 0.41 (95 % CI 0.11 to 0.72) p = 0.017. In both cases, there was small heterogeneity I 2 = 13.2 % respective 38.3 %. The overall ES was estimated 0.67 (95 % CI 0.40 to 0.93) p <0.001. Nevertheless, the heterogeneity was high I 2 = 78.1 %.Conclusion: RT interventions in pre-frail, frail, pre-sarcopenic and sarcopenic older adults, provided evidence that RT has positive effects on most of the outcome measurements included in the current revision except handgrip strength.
Significance of Immune Checkpoint Inhibitors in Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Chemoradiotherapy Prior to the Approval of Durvalumab
Authors: Fukui Tomoya , Hosotani Shinji , Soda Itaru , Ozawa Takahiro , Kusuhara Seiichiro , Kakegawa Mikiko , Kasajima Masashi , Hiyoshi Yasuhiro , Igawa Satoshi , Yokoba Masanori , Mitsufuji Hisashi , Kubota Masaru , Katagiri Masato , Sasaki Jiichiro , Ishiyama Hiromichi , Naoki Katsuhiko 
Published: October 2019

Abstract
Background: The standard treatment for patients with unresectable locally advanced (LA) non-small cell lung cancer (NSCLC) was chemoradiotherapy (CRT). Consolidation therapy with durvalumab, an anti-programmed death ligand-1 antibody, after CRT demonstrated survival benefits and was approved in Japan in July 2018. The use of immune checkpoint inhibitors (ICIs) is entering routine oncological practice, and we investigate the feasibility of concurrent CRT for LA-NSCLC patients based on the PACIFIC criteria.Methods: We performed a retrospective study to evaluate the feasibility and efficacy of concurrent CRT prior to the approval of durvalumab. We assessed consecutive patients with LA-NSCLC treated with CRT between January 2012 and June 2018 in clinical practice, based on the PACIFIC criteria.Results: We analyzed a total of 108 consecutive patients ( 81 males and 27 females) who received radical thoracic radiotherapy and concurrent platinum-based chemotherapy. Of those, 105 patients (97%) completed the planned radiotherapy. Radiation pneumonitis was observed in 93 patients (85%), with a median of 130 days (range: 41–317 days) from the initiation of radiation to the onset of the complication. Among the patients, 74 (69%) were considered eligible for consolidation therapy with durvalumab. The overall response rate was 64%, and the 2-year survival rate was 63%. Of the 82 patients who relapsed after CRT, 18 patients received treatment with an ICI in the course of treatment. Patients who received an ICI after relapse were associated with significantly better survival than those who did not receive an ICI (2-year survival rate: 87% vs. 41%, respectively; p = 0.001).Conclusion: Prior to the approval of durvalumab, the clinical application of ICIs improved the outcome of patients with relapsed NSCLC after CRT for LA-NSCLC. The treatment strategy of ICI consolidation therapy for patients with LA-NSCLC and the management of radiation pneumonitis are challenges following the approval of durvalumab.
Efficacy and safety of dezocine in postoperative pain relief: Systematic review and Meta-analysis
Authors: Hao Fengxi , Fan Zhongyuan , Chen Feng , Yu Yongbo , Ren Yuanzhong , Yang Xuecheng , Wang Yonghua , Chu Haichen , Niu Haitao 
Published: October 2019

Abstract
Objective: To systematically evaluate the efficacy index and adverse reactions of dezocine in postoperative pain relief, provide statistical theoretical support for guiding clinical application.
Methods: We extracted and analyzed multiple data of patients from the PubMed, Embase, The Cochrane Library and China National Knowledge Infrastructure (CNKI) for use in randomized controlled trials of various surgical postoperative pain relief. We used meta-analysis to study several measures of efficacy and safety of dezocine, including visual analogue score (VAS), Ramsay sedation score, mean arterial pressure (MAP), heart rate (HR), Pulse Oxygen Saturation (SpO2) and the incidence of adverse events(AEs). The material data were calculated and analyzed using Review Manager 5.3.
Results: After exclusion of literature that did not meet the inclusion criteria, our analysis included 14 randomized controlled trials. The Mean Difference (MD) of VAS at 1 h/6 h/24h between the dezocine group and the placebo group was -1.37 (95% CI -2.07,-0.67, P=0.0001)，-0.52 (95% CI -1.04,0.01, P=0.05)，-0.10 (95% CI -0.39,0.20, P=0.52), respectively. The MD of Ramsay sedation score at 2h/8h was 1.21 (95% CI 0.67,1.75, P＜0.0001) and -0.17 (95% CI -0.59,0.26, P=0.44). The MD of MAP at T0/T1/T2 was -0.28 (95% CI -2.46,1.89, P=0.80)，-2.66 (95% CI -5.07,-0.25, P=0.03)，-4.53 (95% CI -6.17,-2.89, P＜0.00001). The MD of HR at T0/T1/T2 was -2.26(95% CI -4.32,-0.21, P=0.03)，-3.58(95% CI -5.21,-1.96, P＜0.0001),-3.75 (95% CI -11.55,4.04, P=0.35). The MD of SpO2 at T0/T1 was -0.90(95% CI -1.77,-0.03, P=0.04) and 0.36(95% CI 0.02,0.71, P=0.04).The odds ratio (OR) of AEs was 0.53(95% CI 0.39,0.71, P＜0.0001).
Conclusion: Dezocine shows appropriate anesthetic efficacy and fewer adverse effects, which can reduce postoperative pain effectively.
Comparative transcriptome analysis by Tilletia horrida infection in resistant and susceptible rice (Oryza sativa L.) male sterile lines reveals candidate genes and resistant mechanisms
Authors: Wang Aijun , Yin Desuo , Shu Xinyue , Wang Linxia , Li Ping , Zheng Aiping 
Published: October 2019

Abstract
Background Rice kernel smut (RKS), caused by the basidiomycete fungus Tilletia horrida , is one of the most devastating diseases affecting the production of male sterile lines of rice ( Oryza sativa ) worldwide. However, molecular mechanisms of resistance to T. horrida have not yet been explored.Results In the present study, analysis of the amount of T. horrida biomass in rice kernels and RNA sequencing (RNA-Seq) analysis of rice male sterile lines resistant and susceptible to RKS (Jiangcheng 3A and 9311A, respectively) were conducted after T. horrida infection. Transcriptomic analysis showed that 9, 840 and 7, 902 differentially expressed genes (DEGs) were observed in Jiangcheng3A and 9311A, respectively, after T. horrida inoculation, compared with the control. KEGG analyses of DEGs revealed that cutin, suberine and wax biosynthesis, flavonoid biosynthesis, glutathione metabolism, tyrosine metabolism, and biosynthesis of unsaturated fatty acids were enriched by T. horrida inoculation in Jiangcheng 3A; however, not significantly enriched in 9311A. Furthermore, the DEGs related to plant-pathogen interaction, plant hormone signal transduction, and transcriptional factor genes were identified in both rice male sterile lines.Conclusions This is the first comparative transcriptome analysis of two rice genotypes with different responses to T. horrida infection, revealing DEGs with potentially important roles in defense against T. horrida infection. Ours results will serve as a strong foundation for developing effective strategies for T. horrida -resistance breeding.
The changes of refractive status and anterior segment parameters after strabismus surgery
Authors: Zhou Wenke , Wu Hanyun , Zheng Yumeng , Zhang Li 
Published: October 2019

Abstract
Purpose To investigate the effects of strabismus surgery on the refractive status and anterior segment parameters, meanwhile to conduct a research on the causes of these changes. Methods This was a retrospective study about 65 patients (104 eyes) who underwent strabismus surgery by a single surgeon from February 2017 to May 2018. The patients were divided into 4 groups. Group I: unilateral lateral rectus recession (40 eyes), Group II: unilateral medial rectus recession (16 eyes), Group III: monocular lateral rectus recession and medial rectus resection (30 eyes), Group IV: disinsertion of the inferior oblique (18 eyes). Refractive status and anterior segment parameters were measured at 1 day before operation, 1 week, 1 month and at least 3 month after operation. Results Spherical equivalent significantly showed a myopic shift during postoperative 1 week in horizontal rectus surgery, and it still showed a statistical changes during postoperative at least 3 month unilateral medial rectus recession. J0 displayed a shift in the with-the-rule direction in unilateral medial / lateral rectus recession lasted to the at least 3 month after surgery. J45 had no significant change in all groups as time passed by. Patients manifested statistically significant changes in steepest keratometry at 1 week after operation in horizontal rectus surgery.Flattest keratometry changed significantly only in unilateral medial rectus recession lasted to the at least 3 month after surgery .There was no change in disinsertion of the inferior oblique . Conclusions Refractive changes are a significant side effect of strabismus surgery, therefore, patients should be informed about it prior to surgery and the appropriate time for optometry should be chosen according to the different surgical methods after surgery.
Palliative care quiz for nurses-Indonesian version (PCQN-I): A cross-cultural adaptation, validity, and reliability study
Authors: Herta Nuzul Sri , Wicaksana Anggi Lukman , Effendy Christantie , Kao Chi-Yin 
Published: October 2019

Abstract
Background The palliative care quiz for nurses (PCQN) has been frequently used to assess palliative care knowledge and has been adapted into several languages. The aim of this study was to perform a cross-cultural adaptation of the palliative care quiz for nurses into the Indonesian context (PCQN-I) and evaluate its psychometric properties.Methods A two-stage design was used in this study, including a cross-cultural adaptation and psychometric testing. The PCQN-I was tested on a convenience sample of healthcare providers recruited from 20 primary healthcare (PHC) centers in Yogyakarta, Indonesia, from July to October 2017.Results The cross-cultural adaptation ultimately resulted in a total of 20 items of the PCQN-I. An expert committee revised words in Item 4 “adjuvant therapies” to “adjuvant therapies/additional therapies”; Item 5 “bowel regimen” to “gastrointestinal therapies”; and Item 16 “Demerol” to “Pethidine” according to situation in Indonesia. The experts retained Item 5 “It is crucial for family members to remain at the bedside until death occurs,” although none of the participants (n = 40) involved in the pilot testing could answer it correctly; and Item 19 “The loss of a distant or contentious relationship is easier to resolve than the loss of one that is close or intimate”, although few participants responded correctly. A total of 150 healthcare providers consisting of 100 nurses and 50 physicians were involved in the psychometric testing. The scale-level content validity index/Ave of the PCQN-I was 0.97 and 0.93 in terms of its relevancy and clarity, respectively. The Kuder–Richardson formula 20 score was 0.71.Conclusions The PCQN-I is a valid and reliable instrument for assessing palliative care knowledge among PHC providers. Further research is warranted to examine its reliability in different clinical settings.
Survey of human and bovine tuberculosis infection on dairy farms in southwestern China
Authors: Zhang Shu , Chen Chuang , Rao Zhengyuan , Yang Aiguo , Guo Li , Hou Wei , Zhang Liang , Yang Xiulan , Liu Yan , Wu Yumei 
Published: October 2019

Abstract
Background Tuberculosis is a zoonotic chronic infectious disease that can be transmitted through respiratory secretions, causing simultaneous infection in both people and cattle. The aim of our study was to identify the co-infections of Mycobacterium tuberculosis between human and cattle in dairy farms in Sichuan Province, southwest China.Results We selected 6 large-scale dairy farms and 5 small-scale dairy farms in Sichuan Province, southwest China, as research sites. A total of 378 dairy farm workers (except one pregnant woman)were screened for tuberculosis symptoms and examined by X-ray radiographs. One worker was diagnosed with tuberculosis, but the sputum culture result was negative, and no strain was obtained. The purified protein derivative (PPD) skin tests of 10224 dairy cows showed that 99 cows were positive, with a positive rate of 9.7‰. The Oesophageal-Pharyngeal (OP) secretions of PPD-positive cows were cultured, and 21 strains were obtained. After amplifying and sequencing the 16SrDNA, hsp65 and rpoB genes and the ITS region, sequence alignment in BLAST showed that these strains were nontuberculous mycobacteria (NTM)(18 Mycobacterium nonchromogenicum , 1 Mycobacterium hiberniae , 1 Mycobacterium arupense and 1 Mycobacterium chitae ).Conclusion This study indicated that PPD-positive cows on dairy farms were infected with NTM rather than Mycobacterium bovis . Cross-infection of tuberculosis between humans and cows on dairy farms has been controlled.
Proteomic profiling of canine osteosarcoma patients
Authors: Jaroensong Tassanee , Roytrakul Sittiruk , Thitiyanaporn Chaiyakorn 
Published: October 2019

Abstract
Background Canine osteosarcoma (OSA) is an aggressive primary bone tumor in dogs. Metastasis of canine OSA occurs mainly in the lungs through the hematogenous route. Identification of the proteins that are associated with metastasis using proteomic technologies is important not only for the discovery of OSA targets and signaling pathways associated with metastatic OSA but also to provide novel therapeutic targets. The objective of this study was to conduct a proteomic profiling analysis of canine OSA patients. We used mass spectrometry to examine the protein profiles.Results We found the overexpression of five proteins from OSA tissues—myosin (MYO7a), GTPase IMAP family member 5 isoform 1 (GIMAP5), PR domain 15 (PRDM15), A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), and interleukin receptor type 1 (IL1R1)—and one protein from the serum, rCG38920.Conclusions In this study, we identified numerous proteins in the tissue and serum of patients with malignant and benign OSA or non-OSA through a proteomic approach using mass spectrometry. These proteins may be useful for diagnosis and prognosis, including the prevention of misdiagnosis between malignant OSA and non-OSA as these have similar clinical symptoms in the early stages. In the future, further independent validation of these biomarkers using a greater number of patient samples and different techniques, including Western blot, is necessary to improve diagnostic power for differentiating malignant OSA patients from non-OSA patients.
Resting energy expenditure guided intervention for gestational weight gain in obese and overweight women
Authors: Zhao Xiuling , Ma Wei , Zhang Caixia , Xu Pili , Zhang Chunmei , Jiang Shan , Gaudet Laura , Gao Jie , Wen Shi Wu 
Published: October 2019

Abstract
Background There is sparse in the literature on resting energy expenditure guided intervention to manage gestational weight gain in obese and overweight women.Methods We conducted a prospective cohort study in Beijing, China between May 1, 2017 and April 30, 2018. Obese/overweight women who visited the Department of Obstetrics and Gynecology at LuHe hospital of Capital Medical University, a tertiary care facility in Beijing, China, for their routine prenatal care at 10-13 weeks of gestation during the study period were recruited into the study after written consent was obtained. Women whose pre-pregnant body mass index was < 25Kg/m2 or who took steroid medication or those diagnosed with thyroid disease or affected by pre-pregnant diabetes mellitus or for other reasons could not participate in the study assessments were excluded. Participants who were recruited between May 1, 2017 and December 30, 2017 were the designated control group with diet recommendation based on pre-pregnancy body mass index and ideal weight, without resting energy expenditure monitoring. Those who were recruited between November 1, 2017 and April 30, 2018 were the intervention group, with resting energy expenditure guided diet recommendation to manage gestational weight gain. Gestational weight gain and perinatal outcomes between the two study groups were then compared.Results A total of 53 eligible women (32 in intervention group and 21 in control group) were recruited and included in the final analysis. There was no difference in baseline demographic and clinical characteristics between the two groups. Gestational weight gain in the intervention group (13.45±4.16 Kg) was lower than in the control group (18.20±4.84 Kg). Rate of macrosomia in the intervention group (3.12%) was also lower than in the control group (19.05%). There was no fetal growth restriction observed in either group.
"It Is Just That We Are Alive But We Are Suffering" Experience Of Food Insecurity Among Elderly In Morogoro-tanzania
Authors: KILUME UPENDO , NYAMHANGA TUMAINI 
Published: October 2019

Abstract
Background Studies on food insecurity in Tanzania have been quantitative in nature and have focused on specific population groups such as those of people living with HIV and women. However, there is very little, if any, qualitative research information in Tanzania on experiences of food insecurity among elderly with respect to its magnitude and associated circumstances.Methods Interview guide and focused group discussion guide were used to explore the magnitude of food insecurity among elderly and its associated circumstances. A total of 25 elderly and 3 district officials were involved in in-depth interview and another 25 elderly were involved in focused group discussion.Results The study found that elderly had limited access to food, eat less number of meals as well as insufficient amount. The circumstance associated with food insecurity were found to be limited strength to engage themselves in farm activities or working as casual laborers to earn some money to buy food, limited strength to prepare food, burden of taking care of grandchildren and inadequate food support from children.Conclusion In conclusion, this study has demonstrated that the elderly people experience food insecurity with respect to both quantity and quality. Therefore, it is high time that a strategy was developed to ensure that all elderly in Tanzania are food secure.
Quantifying and interpreting nestedness of bryophytes in the Zhoushan Archipelago, China
Authors: Yu Jing , Li Dandan , Shen Lin , Zhuo Busheng , Guo Shuiliang 
Published: October 2019

Abstract
Background: Detecting nestedness distribution and understanding their origin are important for biological conservation. Although previous studies on nestedness covered a wide range of taxa, discrepancies still exist on the prevalence of nestedness among biotas, and on the mechanisms to form nested distribution. Because bryophytes are poikilohydric, highly sensitive to habitats, and have a long-distance dispersal capacity, together with the fact that continental islands highly varied in area, elevation and habitat types, bryophytes on continental archipelago are thus an ideal system for the settlement of relevant disputes on nested distribution. However, few studies have been conducted on nestedness of bryophytes. To quantify nestedness level of different bryophyte categories on continental islands and possible mechanisms, we complied a presence/absence matrix of 446 species of bryophytes in 66 islands of the Zhoushan Archipelago, China. We also recorded spore sizes of 319 moss species based on available literature. By using the matrix temperature and the NODF metrics, as well as a conservative null model, we evaluated the nestedness levels of 18 bryophyte categories. We further explored possible mechanisms to form nested distribution by using partial Spearman rank correlations based on island area, elevation, habitat types and spore size of moss species.
Results : We found that all 18 categories of bryophytes exhibited a high degree of nestedness. Nestedness level was higher for mosses than liverworts, higher for acrocarpous mosses than pleurocarpous mosses，and varied among different bryophyte 13 families. The nested distribution of bryophytes in the archipelago was not due to passive sampling, but mainly due to nested habitats and selective-extinction. Spore size might be a factor linked to selective-colonization accounting for nestedness of some moss categories.
Conclusions : Nested habitats, selective-extinction, and partial selective-colonization resulted in a high level of nestedness for bryophytes in continental islands. Although the nestedness of bryophyte distribution in the Zhoushan Archipelago was statistically significant, such a nestedness was not perfect. Conservation of bryophytes should not only focus on the species-richest islands.