bluuebunny/crossref_metadata_2025_split huggingface dataset:
A context‐aware recommender method based on text and opinion mining
Authors: Sundermann Camila Vaccari , de Padua Renan , Tonon Vítor Rodrigues , Marcacini Ricardo Marcondes , Domingues Marcos Aurélio , Rezende Solange Oliveira 
Published: August 2020

AbstractA recommender system is an information filtering technology that can be used to recommend items that may be of interest to users. Additionally, there are the context‐aware recommender systems that consider contextual information to generate the recommendations. Reviews can provide relevant information that can be used by recommender systems, including contextual and opinion information. In a previous work, we proposed a context‐aware recommendation method based on text mining (CARM‐TM). The method includes two techniques to extract context from reviews: CIET.5embed, a technique based on word embeddings; and RulesContext, a technique based on association rules. In this work, we have extended our previous method by including CEOM, a new technique which extracts context by using aspect‐based opinions. We call our extension of CARM‐TOM (context‐aware recommendation method based on text and opinion mining). To generate recommendations, our method makes use of the CAMF algorithm, a context‐aware recommender based on matrix factorization. To evaluate CARM‐TOM, we ran an extensive set of experiments in a dataset about restaurants, comparing CARM‐TOM against the MF algorithm, an uncontextual recommender system based on matrix factorization; and against a context extraction method proposed in literature. The empirical results strongly indicate that our method is able to improve a context‐aware recommender system.
A convex hull‐based approach for multiaxial high‐cycle fatigue criteria
Authors: Scalet Giulia 
Published: August 2020

AbstractDesign methods against multiaxial high‐cycle fatigue require the formulation of appropriate criteria that differ in the definition of critical measures introduced to quantify damage, as the amplitude of shear stress. The present paper proposes a novel approach to compute the amplitude of shear stress in multiaxial high‐cycle fatigue. The approach is based on the computation of the convex hull enclosing the stress history under investigation and is validated on proportional and non‐proportional paths in several dimensions and for different materials. High accuracy is achieved when compared with alternative methods from the literature.
Rapid deep ocean deoxygenation and acidification threaten life on Northeast Pacific seamounts
Authors: Ross Tetjana , Du Preez Cherisse , Ianson Debby 
Published: August 2020

AbstractAnthropogenic climate change is causing our oceans to lose oxygen and become more acidic at an unprecedented rate, threatening marine ecosystems and their associated animals. In deep‐sea environments, where conditions have typically changed over geological timescales, the associated animals, adapted to these stable conditions, are expected to be highly vulnerable to any change or direct human impact. Our study coalesces one of the longest deep‐sea observational oceanographic time series, reaching back to the 1960s, with a modern visual survey that characterizes almost two vertical kilometers of benthic seamount ecosystems. Based on our new and rigorous analysis of the Line P oceanographic monitoring data, the upper 3,000 m of the Northeast Pacific (NEP) has lost 15% of its oxygen in the last 60 years. Over that time, the oxygen minimum zone (OMZ), ranging between approximately 480 and 1,700 m, has expanded at a rate of 3.0 ± 0.7 m/year (due to deepening at the bottom). Additionally, carbonate saturation horizons above the OMZ have been shoaling at a rate of 1–2 m/year since the 1980s. Based on our visual surveys of four NEP seamounts, these deep‐sea features support ecologically important taxa typified by long life spans, slow growth rates, and limited mobility, including habitat‐forming cold water corals and sponges, echinoderms, and fish. By examining the changing conditions within the narrow realized bathymetric niches for a subset of vulnerable populations, we resolve chemical trends that are rapid in comparison to the life span of the taxa and detrimental to their survival. If these trends continue as they have over the last three to six decades, they threaten to diminish regional seamount ecosystem diversity and cause local extinctions. This study highlights the importance of mitigating direct human impacts as species continue to suffer environmental changes beyond our immediate control.
Depression screening in adults by pharmacists in the community: a systematic review
Authors: Miller Peter , Newby David , Walkom Emily , Schneider Jennifer , Li Shu Chuen 
Published: August 2020

Abstract

Background
Improving the identification of depression in adults in primary care can produce clinical and economic benefits. Community Pharmacists may play a role in screening for depression.

Objective
To systematically review and evaluate the evidence for the feasibility, impact and cost-effectiveness of community pharmacists screening adults for depression.

Methods
An electronic literature search using the databases EMBASE, PubMed and CINAHL Complete from January 2000 to September 2019 was undertaken to identify studies involving community pharmacists screening for depression. Data relating to sample size, population demographics and medical conditions of adults screened were extracted. Details around the screening model, process-related outcomes, clinical outcomes and economic outcomes were also extracted.

Results
Ten studies using eight unique depression screening tools were identified. Ease of administration was the most common selection criterion (n = 4) while no reason was given in four studies. Seven studies reported that through screening, pharmacists could identify adults with undiagnosed depression. Pharmacists referred adults screening positive for assessment in seven studies and followed up participants in two studies. No study assessed the impact of screening on depressive symptoms or the cost-effectiveness of pharmacists screening for depression.

Conclusion
Community pharmacists are able to use depression screening tools to identify undiagnosed adults having symptoms of depression. However, there is little evidence around the impact of this screening on clinical and economic outcomes. Larger, well-designed studies that use a highly accurate, easily administered screening tool and include patient referral and follow-up and pharmacist training are warranted to provide evidence on the impact of community pharmacists screening adults for depression.
Usefulness of a high‐speed surgical air drill in pubectomy during delayed anastomotic urethroplasty for pelvic fracture urethral injury
Authors: Horiguchi Akio , Ojima Kenichiro , Shinchi Masayuki , Hirano Yusuke , Hamamoto Koetsu , Ito Keiichi , Asano Tomohiko , Azuma Ryuichi 
Published: August 2020

ObjectivesPubectomy is an ancillary technique used to increase exposure of the disrupted urethra and reduce anastomotic tension, which can be difficult for inexperienced surgeons. The objective of the present study was to illustrate the use of an air drill enabling delicate and precise bone resection in pubectomy for delayed anastomotic urethroplasty for pelvic fracture urethral injury.MethodsBetween 2009 and 2019, 88 male patients underwent delayed anastomotic urethroplasty with pubectomy for pelvic fracture urethral injury. A total of 73 procedures used a high‐speed surgical air drill (HiLAN HS; Aesculap, Tuttlingen, Germany) equipped with a short‐hand piece. Operative time and blood loss in the air drill patient group (group 1) were compared with that of patients who underwent pubectomy using a rongeur and/or gouge (group 2, n = 15).ResultsIn 65 group 1 patients, urethroplasty was carried out using the perineal approach, with partial inferior pubectomy. Eight group 1 patients, whose proximal urethral end was displaced upward superior to the upper edge of pubis, underwent urethroplasty using the perineal and abdominal approach, with a superior partial pubectomy and supracrural urethral rerouting. No difficulty was encountered using the air drill in any of the cases. There was no significant difference in median operative time between the groups (group 1 256 min vs group 2 228 min; P = 0.31). The median blood loss in group 1 was significantly lower than group 2 (149 mL vs 453 mL; P < 0.0001).ConclusionsSurgical air drills might facilitate pubectomy in patients undergoing delayed anastomotic urethroplasty for pelvic fracture urethral injury. This tool offers the advantage of a delicate bone resection with reduced blood loss.
The information content of 10‐K file size change
Authors: Gan Quan , Qiu Buhui 
Published: August 2020

AbstractChange in 10‐K file size robustly and negatively predicts future stock returns. The documented return predictability reflects mainly information content of 10‐K file size change on future cash flow news. We examine whether this return predictability derives from managers' risk disclosures or disclosure obfuscation. We find that the return predictability increases in future return horizon. It is driven by positive file size changes and is stronger for firms with high information asymmetry. It is stronger when managers have more “skin in the game.” It persists even when investor attention is high. It derives from the component of file size change that cannot be explained by business fundamentals. Although word count changes in specific 10‐K items can predict future stock returns, word count change in Item 1A, the risk disclosure section, has no return predictability. Our findings are broadly consistent with the managerial disclosure obfuscation explanation and suggest that lengthier 10‐K disclosure, to the extent it is used by managers to obfuscate bad news, does not necessarily benefit shareholders.
Prediction of cardiovascular events using brachial‐ankle pulse wave velocity in hypertensive patients
Authors: Kim Hack‐Lyoung , Lim Woo‐Hyun , Seo Jae‐Bin , Kim Sang‐Hyun , Zo Zoo‐Hee , Kim Myung‐A 
Published: August 2020

AbstractThe prognostic value of arterial stiffness in Korean hypertensive patients has not been specified. This study was performed to evaluate the prognostic value of brachial‐ankle pulse wave velocity (baPWV) in Korean hypertensive patients and to propose a cutoff value of baPWV predicting future cardiovascular events. A total of 2561 hypertensive patients without documented cardiovascular disease (mean age, 63 years; 47% females) who underwent baPWV measurement were retrospectively analyzed. Composite events of cardiac death, non‐fatal myocardial infarction, coronary revascularization, and ischemic stroke were assessed during the clinical follow‐up period. During a median follow‐up period of 4.14 years (interquartile range, 2.18‐5.48 years), there were 69 cases of composite events (2.7%). In receiver operating characteristic curve analysis, the best cutoff value of baPWV predicting composite events was 1630 cm/s (sensitivity, 79.7%; specificity, 49.1%; area under curve, 0.674; 95% confidence interval [CI], 0.613‐0.735; P < .001). In multivariable Cox regression analysis, higher baPWV (≥1630 cm/s) was independently associated with higher risk of the occurrence of composite events even after controlling for potential confounders (hazard ratio, 2.83; 95% confidence interval, 1.49‐5.36; P = .001). In conclusion, increased baPWV in Korean hypertensive patients was associated with an increased risk of future cardiovascular events. In addition, we suggested 1630 cm as a cutoff value of baPWV for predicting cardiovascular events, which will be helpful in guiding the treatment strategy of Korean hypertensive patients.
Curcumin reinforces MSC‐derived exosomes in attenuating osteoarthritis via modulating the miR‐124/NF‐kB and miR‐143/ROCK1/TLR9 signalling pathways
Authors: Qiu Bo , Xu Xiongfeng , Yi Peng , Hao Yarong 
Published: August 2020

AbstractCurcumin treatment was reported to delay the progression of OA, but its underlying mechanism remains unclear. In this study, we aimed to investigate the molecular mechanism underlying the role of curcumin in OA treatment. Accordingly, by conducting MTT and flow cytometry assays, we found that the exosomes derived from curcumin‐treated MSCs helped to maintain the viability while inhibiting the apoptosis of model OA cells. Additionally, quantitative real‐time PCR and Western blot assays showed that the exosomes derived from curcumin‐treated MSCs significantly restored the down‐regulated miR‐143 and miR‐124 expression as well as up‐regulated NF‐kB and ROCK1 expression in OA cells. Mechanistically, curcumin treatment decreased the DNA methylation of miR‐143 and miR‐124 promoters. In addition, the 3’ UTRs of NF‐kB and ROCK1 were proven to contain the binding sites for miR‐143 and miR‐124, respectively. Therefore, the up‐regulation of miR‐143 and miR‐124 in cellular and mouse OA models treated with exosomes remarkably restored the normal expression of NF‐kB and ROCK1. Consequently, the progression of OA was attenuated by the exosomes. Our results clarified the molecular mechanism underlying the therapeutic role of MSC‐derived exosomes in OA treatment.
Viability of Listeria monocytogenes and Salmonella Typhimurium after isochoric freezing
Authors: Bridges David F. , Bilbao‐Sainz Cristina , Powell‐Palm Matthew J. , Williams Tina , Wood Delilah , Sinrod Amanda J. G. , Ukpai Gideon , McHugh Tara H. , Rubinsky Boris , Wu Vivian C. H. 
Published: August 2020

AbstractIsochoric freezing, different from isobaric (conventional) freezing, allows for storage below freezing temperatures without significant damage from ice formation. While several types of tissues have been successfully stored in sub‐zero isochoric conditions, it is unknown how isochoric freezing affects pathogenic microorganisms. Thus, the objective of this study was to investigate the survival of Salmonella Typhimurium and Listeria monocytogenes at below freezing storage (<0°C) in isochoric conditions. Tested conditions included storage at −4, −7, and −15°C for 24 hr and at −15°C for 1, 2, 3, 6, 12, and 24 hr. A comparison of bacterial survival during isobaric freezing was included with every trial. Additionally, bacterial cells were examined for morphological damage using transmission electron and field‐emission scanning electron microscopes. Isochoric freezing at −15°C for 24 hr reduced both species of bacteria down to unrecoverable levels and maximum efficacy achieved after the 6 hr timepoint for L. monocytogenes and the 12 hr timepoint for S. Typhimurium. When viewed using electron microscopy, S. Typhimurium cells were noticeably disfigured with regions of cytosol separated from the cell wall. The results of this study demonstrate that isochoric freezing is capable of substantial levels of pathogen reduction. Unlike conventional nonthermal interventions, isochoric freezing does not require additional devices such as elevated pressure machines or pulsed electric fields and can be achieved with simple, inexpensive, rigid closed volume containers such as household freezers or commercial cold storage facilities.
Evolution of SIVsm in humanized mice towards HIV‐2
Authors: Curlin James , Schmitt Kimberly , Remling‐Mulder Leila , Moriarty Ryan , Goff Kelly , O’Connor Shelby , Stenglein Mark , Marx Preston , Akkina Ramesh 
Published: August 2020

AbstractThrough the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T‐cell decline as the virus was passaged in humanized mice.
Reliability of the Charcot‐Marie‐Tooth functional outcome measure
Authors: Bray Paula , Cornett Kayla M. D. , Estilow Timothy , Pareyson Davide , Zuccarino Riccardo , Skorupinska Mariola , Pipis Menelaos , Sowden Janet E. , Scherer Steven , Reilly Mary M. , Shy Michael E. , Herrmann David N. , Burns Joshua , Eichinger Katy J. 
Published: August 2020

AbstractThe CMT‐FOM is a 13‐item clinical outcome assessment (COA) that measures physical ability in adults with Charcot‐Marie‐Tooth disease (CMT). Test‐retest reliability, internal consistency and convergent validity have been established for the CMT‐FOM. This current study sought to establish inter‐rater reliability. Following an in‐person training of six international clinical evaluators we recruited 10 participants with genetically diagnosed CMT1A, (aged 18‐74 years, 6 female). Participants were evaluated using the CMT‐FOM over 2 days. Participants were given at least a 3 hour rest between evaluations, and were assessed twice each day. Following the provision of training by master trainers, all 13 items of the CMT‐FOM exhibited excellent inter‐rater reliability for raw scores (ICC1,1 0.825‐0.989) and z‐scores (ICC1,1 0.762‐0.969). Reliability of the CMT‐FOM total score was excellent (ICC1,1 0.983, 95% CI 0.958‐0.995). The CMT‐FOM is a reliable COA used by clinical evaluators internationally. The next steps are to establish further validation through psychometric evaluation of the CMT‐FOM in the Accelerate Clinical Trials in CMT (ACT‐CMT) study.
Online and in‐Person Violence, Harassment, Intimidation and Bullying in New Jersey: 2011‐2016
Authors: Simmons Kyle X. , Shah Nimit N. , Fakeh Campbell Maryanne L. , Gonzalez Lauren N. , Jones Laura E. , Shendell Derek G. 
Published: August 2020

ABSTRACTBACKGROUNDNew Jersey (NJ) Safe Schools Program, primarily funded by the NJ Department of Education, has aims concerning safety and health including helping to alleviate harassment, intimidation, and bullying (HIB) in secondary school because HIB can affect learning. We evaluated officially reported adolescent HIB total incidents and estimated rates in NJ public city and county school districts for the 2011‐2016 school years.METHODSA cross‐sectional observational study using population‐based state‐reported public data. We calculated point prevalence and incidence rates for K‐12 students in 22 public city school districts, students in 21 career‐technical‐vocational education (CTE) school districts, and 8 special services school districts during 2011‐2016.RESULTSHIB is prevalent in NJ school classrooms. HIB comprised ≥75% of total officially reported in‐school violence‐related incidents in a given school year. Rates per 100 enrollees of total officially reported incidents for the 5‐year period of 2011‐2016 was highest in special services school districts (5.00; 95% confidence interval [CI]: 4.67, 5.34) followed by CTE districts (1.94; 95% CI: 1.86, 2.01), and lowest in city districts (1.46; 95% CI: 1.44, 1.48). The special services school district also had the highest rates per year and the 5‐year period.CONCLUSIONSData analyses suggested ideas for further research and improvements for school HIB incident reports. Policies and programs could remedy issues observed in state secondary school classrooms. Best practices within districts and schools can help protect students from HIB and promote safety, health, learning, and maturation.
Gingival tissue autophagy pathway gene expression profiles in periodontitis and aging
Authors: Ebersole Jeffrey L. , Kirakodu Sreenatha , Novak Michael J. , Dawson Dolph , Stromberg Arnold J. , Orraca Luis , Gonzalez‐Martinez Janis , Burgos Armando , Gonzalez Octavio A. 
Published: August 2020

AbstractObjectiveWe hypothesized that autophagy‐related genes will be differentially expressed in periodontitis, suggesting an impaired gingival autophagic response associated with disease.BackgroundAutophagy is a cellular physiologic mechanism to maintain tissue homeostasis, while deficient autophagic responses increase inflammation and susceptibility to infection.MethodsRhesus monkeys [<3 years to 23 years of age (n = 34)] were examined for periodontal health and naturally occurring periodontitis. Gingival tissues samples were obtained from healthy or diseased sites, total RNA was isolated, and the Rhesus Gene Chip 1.0 ST (Affymetrix) was used for gene expression analysis of 150 autophagy‐related genes.ResultsComparison of expression levels with adult healthy tissues demonstrated a rather limited number of individual genes that were significantly different across the age‐groups. In contrast, with periodontitis in the adults and aged animals, about 15% of the genes were significantly increased or decreased. The differences were reflected in the mTOR complex (5/12), ULK1/ATG1 complex (5/9), PI3K complex (5/21), ATG9 complex (2/7), ATG12 conjugation/LC3 lipidation (7/22), and lysosome fusion/vesicle degradation [LF/VD (5/10)] activities within the broader autophagic pathway. The genes most greatly altered in gingival tissues of naturally occurring periodontitis were identified in the ATG12 and LF/VD pathways that approximated 50% of the genes in each of those categories. While healthy gingival aging did not appear to reflect altered autophagy gene expression, substantial differences were noted with periodontitis irrespective of the age of the animals. Future studies into the role of autophagy in periodontitis and could offer potential new therapeutic strategies to prevent and/or treat periodontal disease.
Do dreams tell the future? Dream content as a predictor of cognitive deterioration in Parkinson’s disease
Authors: Bugalho Paulo , Ladeira Filipa , Barbosa Raquel , Marto João Pedro , Borbinha Cláudia , Salavisa Manuel , da Conceição Laurete , Saraiva Marlene , Fernandes Marco , Meira Bruna 
Published: August 2020

AbstractCross‐sectional studies suggest a correlation between alterations in dream content reports and executive dysfunction tests in Parkinson’s disease (PD), but this has not been assessed in longitudinal studies. Our objective was to assess the predictive value of dream content for progression of cognitive dysfunction in PD. We prospectively addressed all consecutive, non‐demented patients with PD attending an outpatient clinic during a 1‐year period. Dream reports were collected at baseline by means of a dream diary and analysed according to the Hall and Van de Castle system. Patients were assessed at baseline for rapid eye movement sleep behaviour disorder, motor stage, mood disorder and psychosis. The Montreal Cognitive Assessment (MoCA) was applied at baseline and 4 years later. Linear regression analysis was used to the test the relation between each dream index (predictors), demographic and other motor and non‐motor variables (covariates), and change in MoCA scores (dependent variable). In all, 58 patients were assessed at both time points and 23 reported at least one dream (range 1–27, total 148). Aggression, physical activities, and negatively toned content predominated in dream reports. The MoCA scores decreased significantly from baseline to follow‐up. In the multivariate model, negative emotion index was the strongest predictor of cognitive decline. We found a significant positive association between negative emotions in dreams at baseline and subsequent reduction in MoCA scores. These findings suggest that some dream content in patients with PD could be considered a predictor of cognitive decline, independent of other factors known to influence either dream content or cognitive deterioration.