bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-year outcomes of the MINIject drainage system for uncontrolled glaucoma from the STAR-I first-in-human trial
Authors: Denis Philippe , Hirneiß Christoph , Durr Georges M , Reddy Kasu Prasad , Kamarthy Anita , Calvo Ernesto , Hussain Zubair , Ahmed Iqbal K 
Published: October 2020

Background/AimsThe current study evaluates the efficacy and safety of the stand-alone implantation of the MINIject (iSTAR Medical, Wavre, Belgium) supraciliary, microinvasive glaucoma drainage device in patients with medically uncontrolled open-angle glaucoma.MethodsThis prospective, multicentre, first-in-human, single-arm interventional study evaluated stand-alone, ab interno implantation in 25 patients of a 5 mm long uveoscleral device made of STAR biocompatible material, which is a soft, microporous, flexible silicone. The primary outcome was the reduction of intraocular pressure (IOP) at 6 months compared with baseline, and follow-up continued until 2 years for 21 patients. Secondary outcomes included success defined as diurnal IOP of ≤21 mmHg and >5 mmHg with an IOP reduction of 20% without (complete) or with/without (qualified) glaucoma medication.ResultsMean baseline IOP was 23.2±2.9 mmHg on 2.0±1.1 glaucoma medication ingredients and decreased to 13.8±3.5 mmHg (−40.7% reduction) on 1.0±1.3 medications 2 years after implantation. Complete success was achieved in 47.6% of patients (10/21) and qualified success in 100% of patients (21/21) at the 2-year follow-up. All patients achieved a 20% IOP reduction with 48% of patients medication-free. No serious ocular adverse events or additional glaucoma surgery were reported. Mean central endothelial cell density (ECD) mildly decreased from 2411 cells/mm2 (n=26) to 2341 cells/mm2 (n=21) at 24 months, which represents a 5% decrease for matched eyes. No patient had a ≥30% decrease in central ECD.ConclusionThis first-in-human study on the stand-alone implantation of the MINIject supraciliary drainage system shows promising IOP-lowering results and medication reduction over 24 months with few adverse events.Trial registration numberNCT03193736.
Efficacy and safety of oral valganciclovir in cytomegalovirus anterior uveitis with uncontrolled intraocular pressure
Authors: Wong Mandy O M , Yu Amy H Y , Chan Carmen K M 
Published: October 2020

Background/aimsWhile cytomegalovirus (CMV) anterior uveitis (AU) patients often require glaucoma surgery, the effectiveness of systemic anti-viral in long-term intraocular pressure (IOP) control is not well established. Our study aims to identify the 2-year efficacy and safety of oral valganciclovir in CMV AU with uncontrolled IOP.MethodsIn this retrospective case series, one eye from each of 17 immunocompetent PCR-proven patients with CMV AU who received a single course of oral valganciclovir for 20–148 days for medically uncontrolled IOP during 2008–2018 were identified. They were examined at baseline, week 2, months 1, 2 and 3, then every 3 months up to 2 years after commencement of valganciclovir, or until IOP-lowering procedure.ResultsMedian baseline IOP and IOP-lowering medication were 27.0 mm Hg (IQR: 22.9–31.0 mm Hg), and 4.0, respectively. IOP was significantly lower than baseline from 2 weeks to 12 months and at 21 and 24 months after starting valganciclovir (p=0.001 to 0.041, Wilcoxon sign-rank test), with 16.9–46.0% median IOP reduction. Seven (41.2%) and six (35.3%) patients had IOP≤21 mm Hg with same, or reduced, topical medications by 12 and 24 months, respectively. Median time to IOP-lowering intervention or second course of valganciclovir was 12.4 months. There was no serious medication-related adverse event. Common side effects included reduced monocyte count (9 patients) and deranged renal function/electrolytes (5 patients). IOP spike and wound leak occurred in 35.5% and 29.4% of patients, respectively, after diagnostic aqueous tap.ConclusionIn CMV AU with uncontrolled IOP, >1/3 of the patients avoided glaucoma surgery over 2 years with a course of oral valganciclovir.
Ten-year survival trends of neovascular age-related macular degeneration at first presentation
Authors: Arpa Cristina , Khalid Hagar , Chandra Shruti , Wagner Siegfried , Fasler Katrin , Faes Livia , Pooprasert Pakinee , Chopra Reena , Moraes Gabriella , Balaskas Konstantinos , Keane Pearse A , Sivaprasad Sobha , Fu Dun Jack 
Published: October 2020

BackgroundTo describe 10-year trends in visual outcomes, anatomical outcomes and treatment burden of patients receiving antivascular endothelial growth factor (anti-VEGF) therapy for neovascular age-related macular degeneration (nAMD).MethodsRetrospective cohort study of treatment-naïve, first-affected eyes with nAMD started on ranibizumab before January 1, 2009. The primary outcome was time to best-corrected visual acuity (BCVA) falling ≤35 ETDRS letters after initiating anti-VEGF therapy. Secondary outcomes included time to BCVA reaching ≥70 letters, proportion of eyes with BCVA ≥70 and ≤35 letters in 10 years, mean trend of BCVA and central retinal thickness over 10 years, and mean number of injections.ResultsFor our cohort of 103 patients, Kaplan-Meier analyses demonstrated median time to BCVA reaching ≤35 and ≥70 letters were 37.8 (95% CI 22.2 to 65.1) and 8.3 (95% CI 4.8 to 20.9) months after commencing anti-VEGF therapy, respectively. At the final follow-up, BCVA was ≤35 letters and ≥70 letters in 41.1% and 21%, respectively, in first-affected eyes, while this was the case for 5.4% and 48.2%, respectively, in a patient’s better-seeing eye. Mean injection number was 37.0±24.2 per eye and 53.6±30.1 at patient level (63.1% of patients required injections in both eyes).ConclusionsThe chronicity of nAMD disease and its management highlights the importance of long-term visual prognosis. Our analyses suggest that one in five patients will retain good vision (BCVA ≥70 ETDRS letters) in the first-affected eye at 10 years after starting anti-VEGF treatment; yet, one in two patients will have good vision in their better-seeing eye. Moreover, our data suggest that early treatment of nAMD is associated with better visual outcomes.
Ten-year outcomes of microkeratome-assisted lamellar keratoplasty for keratoconus
Authors: Yu Angeli Christy , Franco Elena , Caruso Lorenzo , Myerscough James , Spena Rossella , Fusco Fiorella , Socea Sergiu , Bovone Cristina , Busin Massimo 
Published: October 2020

Background/AimsTo report the 10-year outcomes of modified microkeratome-assisted lamellar keratoplasty (LK) for keratoconus.MethodsIn this single-centre interventional case series, 151 consecutive eyes with keratoconus underwent modified microkeratome-assisted LK. Eyes with scars extending beyond the posterior half of the corneal stroma and preoperative thinnest-point pachymetry value of less than 300 μm were excluded. Outcome measures were best spectacle-corrected visual acuity (BSCVA), refractive astigmatism (RA), endothelial cell density, immunological rejection, ectasia recurrence and graft failure rates.ResultsBaseline BSCVA (0.89±0.31 logarithm of the minimum angle of resolution (logMAR)) significantly improved to 0.10±0.12 logMAR at year 3 (p<0.001), and remained stable up to 10 years. At 10 years, 94% of eyes saw ≥20/40, 61% saw ≥20/25 and 24% saw ≥20/20 Snellen BSCVA. At final follow-up, RA exceeding 4.5 dioptres was observed in 5 cases (4%). Endothelial cell loss was 25±17% at 1 year with an annual decline of 2% over 10 years. The 10-year cumulative risk for immunological rejection and graft failure was 8.5%, and 2.4%, respectively. No case developed recurrent ectasia at 10 years.ConclusionModified microkeratome-assisted LK results in stable visual and refractive outcomes with low rates of immunological rejection and graft failure in the absence of recurrence of ectasia for at least 10 years.
Do vigorous-intensity and moderate-intensity physical activities reduce mortality to the same extent? A systematic review and meta-analysis
Authors: Rey Lopez Juan Pablo , Sabag Angelo , Martinez Juan Maria , Rezende Leandro F M , Pastor-Valero Maria 
Published: October 2020

ObjectiveTo examine whether vigorous-intensity physical activity confers additional reductions on all-cause and cause-specific mortality compared with moderate-intensity physical activity.DesignA systematic review (registered in PROSPERO CRD42019138995) and meta-analysis.Data sourcesThree electronic databases up to April 14 2020.Eligibility criteriaInclusion criteria were prospective studies that contained information about (1) moderate-intensity (3–5.9 metabolic equivalent tasks (METs)) and vigorous-intensity (≥6 METs) physical activities and (2) all-cause and/or cause-specific mortality. Exclusion criteria were prospective studies that (1) exclusively recruited diseased patients (eg, hypertensive patients and diabetics) or (2) did not account for total physical activity in their multivariable models (3) or did not adjust or exclude individuals with comorbidities at baseline or (4) used physically inactive participants as reference group.ResultsFive studies (seven cohorts using sex-specific results) were pooled into a meta-analysis. For all-cause mortality and controlling by total physical activity, vigorous-intensity physical activity (vs moderate) was not associated with a larger reduction in mortality (HR 0.95, 95% CI 0.83 to 1.09). After the exclusion of one study judged with critical risk of bias (Risk Of Bias in Non randomized Studies, ROBINS tool) from meta-analysis, results remained similar (HR 0.98, 95% CI 0.85 to 1.12). Due to the limited number of studies, meta-analyses for cancer and cardiovascular mortality were not performed.ConclusionsProspective studies suggest that, for the same total physical activity, both vigorous-intensity and moderate-intensity physical activities reduce all-cause mortality to the same extent. However, absence of evidence must not be interpreted as evidence of absence due to the existing methodological flaws in the literature.
Video games and their associations with physical health: a scoping review
Authors: Huard Pelletier Vincent , Lessard Arianne , Piché Florence , Tétreau Charles , Descarreaux Martin 
Published: October 2020

ObjectiveThe objective of this scoping review is to investigate the possible links between the practice of video games and physical health. It seeks to answer the following question: What are the physical health consequences of playing video games in healthy video game player? and How is it currently investigated?.MethodsA scoping review was conducted to identify observational and experimental studies pertaining to our research question. Retrieved papers were screened using a two-phase method first involving a selection based on titles and abstracts. Then, potentially relevant studies were read and triaged. The final set of included studies was analysed, and data were subsequently extracted. Observational studies and experimental studies were assessed using the appropriate Cochrane Risk of Bias Tool and data were synthetised according to specific physical health and related health behaviours.ResultsTwelve peer-reviewed articles were retained for further analyses. Results of this scoping review suggest preliminary evidence that time spent gaming is associated with some health outcomes indicators. Our results indicate preliminary evidence that increased gaming time is associated with higher body mass index and lower self-reported general health status. There is insufficient evidence to conclude on a possible association between gaming time and physical activity or sedentary behaviours, sleep or fatigue, musculoskeletal pain or dietary behaviours.ConclusionThe results of this sopping review suggest an association between increased video game playing time and a deterioration in some physical health indicators but available evidence is scarce, precluding from any strong conclusion.
Impact of COVID-19 on vulnerable patients with rheumatic disease: results of a worldwide survey
Authors: Mehta Bella , Jannat-Khah Deanna , Fontana Mark Alan , Moezinia Carine J , Mancuso Carol A , Bass Anne R , Antao Vinicius C , Gibofsky Allan , Goodman Susan M , Ibrahim Said 
Published: October 2020

ObjectiveThere is emerging evidence that COVID-19 disproportionately affects people from racial/ethnic minority and low socioeconomic status (SES) groups. Many physicians across the globe are changing practice patterns in response to the COVID-19 pandemic. We sought to examine the practice changes among rheumatologists and what they perceive the impact to be on their most vulnerable patients.MethodsWe administered an online survey to a convenience sample of rheumatologists worldwide during the initial height of the pandemic (between 8 April and 4 May 2020) via social media and group emails. We surveyed rheumatologists about their opinions regarding patients from low SES and racial/ethnic minority groups in the context of the COVID-19 pandemic. Mainly, what their specific concerns were, including the challenges of medication access; and about specific social factors (health literacy, poverty, food insecurity, access to telehealth video) that may be complicating the management of rheumatologic conditions during this time.Results548 rheumatologists responded from 64 countries and shared concerns of food insecurity, low health literacy, poverty and factors that preclude social distancing such as working and dense housing conditions among their patients. Although 82% of rheumatologists had switched to telehealth video, 17% of respondents estimated that about a quarter of their patients did not have access to telehealth video, especially those from below the poverty line. The majority of respondents believed these vulnerable patients, from racial/ethnic minorities and from low SES groups, would do worse, in terms of morbidity and mortality, during the pandemic.ConclusionIn this sample of rheumatologists from 64 countries, there is a clear shift in practice to telehealth video consultations and widespread concern for socially and economically vulnerable patients with rheumatic disease.
Differential interferometry using a Bose-Einstein condensate
Authors: Gersemann Matthias , Gebbe Martina , Abend Sven , Schubert Christian , Rasel Ernst M. 
Published: October 2020

Abstract
Out of a single Bose-Einstein condensate (BEC), we create two simultaneous interferometers, as employed for the differentiation between rotations and accelerations. Our method exploits the precise motion control of BECs combined with the precise momentum transfer by double Bragg diffraction for interferometry. In this way, the scheme avoids the complexity of two BEC sources and can be readily extended to a six-axis quantum inertial measurement unit.

Graphical abstract
Reversible elastic phase field approach and application to cell monolayers
Authors: Chojowski Robert , Schwarz Ulrich S. , Ziebert Falko 
Published: October 2020

Abstract.
Motion and generation of forces by single cells and cell collectives are essential elements of many biological processes, including development, wound healing and cancer cell migration. Quantitative wound healing assays have demonstrated that cell monolayers can be both dynamic and elastic at the same time. However, it is very challenging to model this combination with conventional approaches. Here we introduce an elastic phase field approach that allows us to predict the dynamics of elastic sheets under the action of active stresses and localized forces, e.g. from leader cells. Our method ensures elastic reversibility after release of forces. We demonstrate its potential by studying several paradigmatic situations and geometries relevant for single cells and cell monolayers, including elastic bars, contractile discs and expanding monolayers with leader cells.

Graphical abstract
Rudolf Ladenburg and the first quantum interpretation of optical dispersion
Authors: Taltavull Marta Jordi 
Published: October 2020

AbstractIn 1921, the experimental physicist Rudolf Ladenburg put forward the first quantum interpretation of optical dispersion. Theoretical physicists had tried to explain dispersion from the point of view of quantum theory ever since 1913, when Niels Bohr proposed his quantum model of atom. Yet, their theories proved unsuccessful. It was Ladenburg who gave a breakthrough step toward our quantum understanding of dispersion. In order to understand Ladenburg’s step, I analyze Ladenburg’s experimental work on dispersion prior to 1913, the reasons why the first theories of dispersion after 1913 were not satisfactory, and Ladenburg’s 1921 proposal. I argue that Ladenburg’s early experimental work on dispersion is indispensable to understand his 1921 paper. The specific kind of experiments he performed before 1913, the related interpretative problems, and the way he tried to solve them, led him reapproach the dispersion problem in 1921 in a way that was completely different from the way theoretical physicists had done it before.
Theory of supercurrent in superconductors
Authors: Koizumi Hiroyasu , Ishikawa Alto 
Published: October 2020

According to the standard theory of superconductivity, the origin of superconductivity is electron pairing. The induced current by a magnetic field is calculated by the linear response to the vector potential, and the supercurrent is identified as the dissipationless flow of the paired electrons, while single electrons flow with dissipation. This supercurrent description suffers from the following serious problems: (1) it contradicts the reversible superconducting-normal phase transition in a magnetic field observed in type I superconductors; (2) the gauge invariance of the supercurrent induced by a magnetic field requires the breakdown of the global [Formula: see text] gauge invariance, or the nonconservation of the particle number; and (3) the explanation of the ac Josephson effect is based on the boundary condition that is different from the real experimental one. We will show that above problems are resolved if the supercurrent is attributed to the collective mode arising from the Berry connection for many-body wavefunctions. Problem (1) is resolved by attributing the appearance and disappearance of the supercurrent to the abrupt appearance and disappearance of topologically protected loop currents produced by the Berry connection; problem (2) is resolved by assigning the non-conserved number to that for the particle number participating in the collective mode produced by the Berry connection; and problem (3) is resolved by identifying the relevant phase in the Josephson effect is that arising from the Berry connection, and using the modified Bogoliubov transformation that conserves the particle number. We argue that the required Berry connection arises from spin-twisting itinerant motion of electrons. For this motion to happen, the Rashba spin–orbit interaction has to be added to the Hamiltonian for superconducting systems. The collective mode from the Berry connections is stabilized by the pairing interaction that changes the number of particles participating in it; thus, the superconducting transition temperatures for some superconductors is given by the pairing energy gap formation temperature as explained in the BCS theory. The topologically protected loop currents in this case are generated as cyclotron motion of electrons that is quantized by the Berry connection even without an external magnetic field. We also explain a way to obtain the Berry connection from spin-twisting itinerant motion of electrons for a two-dimensional model where the on-site Coulomb repulsion is large and doped holes form small polarons. In this model, the electron pairing is not required for the stabilization of the collective mode, and the supercurrent is given as topologically protected spin-vortex-induced loop currents (SVILCs).
How to Be a Pilgrim: Guidebooks on the Norwegian St. Olav Ways and the Heritagization of Religion
Authors: Johannsen Dirk , Ohrvik Ane 
Published: October 2020

Abstract
The Norwegian St. Olav Ways are currently the largest Northern European project re-institutionalizing pilgrimage as cultural heritage, providing a new framework for vernacular religious practices to a wide audience. In this article we approach the current pilgrimage revival in Northern Europe as part of a trend toward a heritagization of religion that allows new religious self-understandings to emerge. We analyze pilgrim guidebooks to the St. Olav Ways with regard to their narrative scripts, detailing how they can create expectations, inform the pilgrims’ conduct, and direct their attention toward a history that translates into a heritage. Based on a corpus of published pilgrim journals and diaries, we argue that the guidebooks instruct a process of interpretive drift, which influence the pilgrims toward embracing and embodying a new role within the religious field. The guidebooks invite the pilgrims to take on the role of heirs to a medieval European tradition.
Restrictions on Religions due to the covid-19 Pandemic
Authors: Begović Nedim 
Published: October 2020

Abstract
This article explores the restrictions that have been recently placed on religions in Bosnia and Herzegovina on congregating and conducting religious rituals during the covid-19 pandemic, as well as the perceptions and responses of the main religious communities to these restrictions. Our data sources included the state covid-19 regulations, the guidelines of religious communities regarding worship services, congregational prayers, and other activities during the pandemic, and media articles covering religion and the covid-19 issues on a domestic and regional scale. Our research has shown that not all religious communities have been equally supportive of state regulations that restricted the religious freedom of individuals and religious communities. Their responses have ranged from strict harmonization of internal religious guidelines with the state covid-19 regulations to declarative support of public health recommendations while ignoring them in practice.
Commercial-Aircraft-Based Observations for NWP: Global Coverage, Data Impacts, and COVID-19
Authors: James Eric P. , Benjamin Stanley G. , Jamison Brian D. 
Published: October 2020

AbstractWeather observations from commercial aircraft constitute an essential component of the global observing system and have been shown to be the most valuable observation source for short-range numerical weather prediction (NWP) systems over North America. However, the distribution of aircraft observations is highly irregular in space and time. In this study, we summarize the recent state of aircraft observation coverage over the globe and provide an updated quantification of its impact upon short-range NWP forecast skill. Aircraft observation coverage is most dense over the contiguous United States and Europe, with secondary maxima in East Asia and Australia/New Zealand. As of late November 2019, 665 airports around the world had at least one daily ascent or descent profile observation; 400 of these come from North American or European airports. Flight reductions related to the COVID-19 pandemic have led to a 75% reduction in aircraft observations globally as of late April 2020. A set of data denial experiments with the latest version of the Rapid Refresh NWP system for recent winter and summer periods quantifies the statistically significant positive forecast impacts of assimilating aircraft observations. A special additional experiment excluding approximately 80% of aircraft observations reveals a reduction in forecast skill for both summer and winter amounting to 30%–60% of the degradation seen when all aircraft observations are excluded. These results represent an approximate quantification of the NWP impact of COVID-19-related commercial flight reductions, demonstrating that regional NWP guidance is degraded as a result of the decreased number of aircraft observations.