bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains
Authors: Kwapisz Ewa , Garbacz Katarzyna , Kosecka-Strojek Maja , Schubert Justyna , Bania Jacek , Międzobrodzki Jacek 
Published: November 2020

AbstractThe oral cavity may comprise a significant reservoir for Staphylococcus aureus but the data on molecular epidemiology and clonal distribution of oral strains are really scarce. This study aimed to evaluate the clonal relatedness in S. aureus isolated from oral cavity and their relationship with carriage of virulence genes, and antimicrobial resistance profiles. A total of 139 oral S. aureus isolates were obtained from 2327 analysed oral samples of dental patients. Antimicrobial susceptibility testing was performed. Isolates were characterized using protein A gene (spa) typing, spa-CC clonal complexes, toxin genes and SCCmec typing for MRSA. High resistance rates for penicillin, tetracycline and gentamicin were detected, respectively 58.3%, 42.4%, and 35.2%. Twelve (8.6%) S. aureus isolates were identified as MRSA. All of MRSA isolates were mecA-positive and mecC-negative. SCCmec IV was the most common type (66.7%), which was typical for community-acquired MRSA (CA-MRSA). Overall, the enterotoxin gene cluster (egc) was the most frequent detected virulence factor (44.9%), both in MSSA and MRSA isolates. Presence of genes encoding for the enterotoxins (sea, seb, sec, seh, sek), exfoliative toxin A (eta), and toxic shock syndrome toxin-1 (tst) was also observed. Strains carrying lukS-PV/lukF-PV genes belonged to SCCmecV- spa type t437. The most prevalent spa types were t091, t015, t084, t002, t571, and t026 among all 57 identified. Spa types, including 3 new ones, grouped in 6 different spa-CC clonal complexes, with four major dominated; CC45, CC30, CC5, and CC15. This study demonstrated that both methicillin-susceptible and methicillin-resistant major European clones of S. aureus could be isolated from the oral cavity of dental patients, with the emergence of PVL-positive CA-MRSA strains. The oral cavity should be considered as a possible source of toxigenic egc-positive S. aureus strains, in terms of potential risk of cross-infection and dissemination to other body sites.
Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
Authors: Villalba Adrian , Rodriguez-Fernandez Silvia , Perna-Barrull David , Ampudia Rosa-Maria , Gomez-Muñoz Laia , Pujol-Autonell Irma , Aguilera Eva , Risueño Ruth M. , Cano-Sarabia Mary , Maspoch Daniel , Vázquez Federico , Vives-Pi Marta 
Published: November 2020

AbstractType 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. It has been previously demonstrated that liraglutide, a glucagon-like peptide-1 receptor agonist, restores β-cell mass in type 1 diabetes, via α-cell transdifferentiation and neogenesis. We report here that treatment with liraglutide does not prevent type 1 diabetes in the spontaneous non-obese diabetic (NOD) mouse model, but it tends to reduce leukocytic islet infiltration. However, in combination with an immunotherapy based on tolerogenic liposomes, it is effective in ameliorating hyperglycaemia in diabetic NOD mice. Importantly, liraglutide is not detrimental for the tolerogenic effect that liposomes exert on dendritic cells from patients with type 1 diabetes in terms of membrane expression of molecules involved in antigen presentation, immunoregulation and activation. Moreover, the in vivo effect of the combined therapy was tested in mice humanised with peripheral blood mononuclear cells from patients with type 1 diabetes, showing no adverse effects in leukocyte subsets. In conclusion, the combination therapy with liraglutide and a liposome-based immunotherapy is a promising candidate strategy for type 1 diabetes.
Intrinsic brain activity associated with eye gaze during mother–child interaction
Authors: Kuboshita Ryo , Fujisawa Takashi X. , Makita Kai , Kasaba Ryoko , Okazawa Hidehiko , Tomoda Akemi 
Published: November 2020

AbstractMother–child interactions impact child social development and psychological health. This study focused on eye-gaze interactions, especially eye contact as synchronized gaze, which is an important non-verbal communication tool in human interactions. We performed brain-image analysis of mothers and children using resting-state functional magnetic resonance imaging and quantitatively evaluated the quality of mother–child interactions using the Interaction Rating Scale to investigate how it is related to the frequency of mother–child eye contact. As a result, we found a positive correlation between the frequency of eye gaze and the right anterior insula (AI) or middle frontal gyrus in children and a positive correlation with the anterior cingulate cortex (ACC) and precuneus/cuneus in mothers.
Especially, when eye contact was made, the association with the right AI in children and ACC in mothers was retained, suggesting the involvement of the salience network responsible for modulating internal and external cognition. In addition, the frequency of eye contact was positively associated with the quality of mother–child interaction. These results suggest that the salience network is a major candidate for the neural basis involved in maintaining efficient eye contact and that it plays an important role in establishing positive mother–child interactions.
Chirality effects on an electron transport in single-walled carbon nanotube
Authors: Charoenpakdee J. , Suntijitrungruang Ongart , Boonchui S. 
Published: November 2020

AbstractIn our work, we investigate characteristics of conductivity for single-walled carbon nanotubes caused by spin–orbit interaction. In the case study of chirality indexes, we especially research on the three types of single-walled carbon nanotubes which are the zigzag, the chiral, and the armchair. The mathematical analysis employed for our works is the Green-Kubo Method. For the theoretical results of our work, we discover that the chirality of single-walled carbon nanotubes impacts the interaction leading to the spin polarization of conductivity. We acknowledge such asymmetry characteristics by calculating the longitudinal current–current correlation function difference between a positive and negative wave vector in which there is the typical chiral-dependent. We also find out that the temperature and the frequency of electrons affect the function producing the different characteristics of the conductivity. From particular simulations, we obtain that the correlation decrease when the temperature increase for a low frequency of electrons. For high frequency, the correlation is nonmonotonic temperature dependence. The results of the phenomena investigated from our study express different degrees of spin polarization in each chiral of single-walled carbon nanotube and significant effects on temperature-dependent charge transport according to carrier backscattering. By chiral-induced spin selectivity that produces different spin polarization, our work could be applied for intriguing optimization charge transport.
Predictive biomarkers for the progression of ocular complications in chronic Stevens-Johnson syndrome and toxic Eeidermal necrolysis
Authors: Yoshikawa Yamato , Ueta Mayumi , Nishigaki Hiromi , Kinoshita Shigeru , Ikeda Tsunehiko , Sotozono Chie 
Published: November 2020

AbstractThis study aimed to clarify predictive biomarkers of mild and severe ocular complications of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) by examining the cytokines in tears. In 121 chronic-phase SJS/TEN eyes, cytokines in tear samples collected using Schirmer test strips were measured, and ocular sequelae severity was evaluated using an Ocular Surface Grading Score (OSGS) involving 7 components (conjunctivalization, neovascularization, opacification, keratinization, symblepharon, and upper/lower conjunctival-sac shortening), with findings categorized into grades 0–3 (maximum total OSGS: 21). Changes in cytokines between the mild and severe groups (mild: total OSGS of 10 or less, severe: total OSGS of 11 or more), and changes between SJS/TEN cases with and without each of the 7 components, were compared. In the severe group, there was significant upregulation of interleukin (IL)-8 (P < 0.01) and Granzyme B (GrzB) (P < 0.05). IL-8 was significantly upregulated in eyes with conjunctivalization, neovascularization, or opacification, GrzB was upregulated in eyes with keratinization, interferon-γ-inducible protein 10 (IP-10) was downregulated in eyes with conjunctivalization or neovascularization, and IL-1α was upregulated in eyes with opacification (all: P < 0.05). IL-8 and IP-10 was involved in conjunctivalization and neovascularization, while GrzB was involved in keratinization. IL-8 and GrzB in tears may reflect SJS/TEN-related ocular sequelae severity.
Using CHADS2 and CHA2DS2-VASc scores for mortality prediction in patients with chronic kidney disease
Authors: Hsu Po-Chao , Lee Wen-Hsien , Chen Szu-Chia , Tsai Yi-Chun , Chen Ying-Chih , Chu Chun-Yuan , Lin Tsung-Hsien , Voon Wen-Chol , Lai Wen-Ter , Sheu Sheng-Hsiung , Su Ho-Ming 
Published: November 2020

AbstractChronic kidney disease (CKD) is a public health issue and is associated with high morbidity and mortality. How to identify the high-risk CKD patients is very important to improve the long-term outcome. CHADS2 and CHA2DS2-VASc scores are clinically useful scores to evaluate the risk of stroke in patients with atrial fibrillation. However, there was no literature discussing about the usefulness of CHADS2 and CHA2DS2-VASc scores for cardiovascular (CV) and all-cause mortality prediction in CKD patients. This longitudinal study enrolled 437 patients with CKD. CHADS2 and CHA2DS2-VASc scores were calculated for each patient. CV and all-cause mortality data were collected for long-term outcome prediction. The median follow-up to mortality was 91 (25th–75th percentile: 59–101) months. There were 66 CV mortality and 165 all-cause mortality. In addition to age and heart rate, CHADS2 and CHA2DS2-VASc scores (both P value < 0.001) were significant predictors of CV and all-cause mortality in the multivariate analysis. Besides, in direct comparison of multivariate model, basic model + CHA2DS2-VASc score had a better additive predictive value for all-cause mortality than basic model + CHADS2 score (P = 0.031). In conclusion, our study showed both of CHADS2 and CHA2DS2-VASc scores were significant predictors for long-term CV and all-cause mortality in CKD patients and CHA2DS2-VASc score had a better predictive value than CHADS2 score for all-cause mortality in direct comparison of multivariate model. Therefore, using CHADS2 and CHA2DS2-VASc scores to screen CKD patients may be helpful in identifying the high-risk group with increased mortality.
Molecular iodine-catalyzed multicomponent synthesis of α-cyanopyrrolines with ambient air as the oxidant under neat conditions
Authors: Gui Qing-Wen , Teng Fan , Li Zhou-Chao , Jin Xue-Feng , Zhang Mei , Dai Jia-Ni , Lin Ying-Wu , Cao Zhong , He Wei-Min 
Published: November 2020

An eco-friendly and practical method for synthesizing α-cyanopyrrolines via iodine-catalyzed multicomponent tandem reaction of alkenes, TMSCN and N,N-disubstituted formamides with ambient air as the sole oxidant was developed.
ACE2 and gut amino acid transport
Authors: Camargo Simone M.R. , Vuille-dit-Bille Raphael N. , Meier Chantal F. , Verrey François 
Published: November 2020

Abstract
ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a broad tissue distribution with highest expression levels at the brush border membrane (BBM) of small intestine enterocytes and a lower expression in stomach and colon. In small intestinal mucosa, ACE2 mRNA expression appears to increase with age and to display higher levels in patients taking ACE-inhibitors (ACE-I). There, ACE2 protein heterodimerizes with the neutral amino acid transporter Broad neutral Amino acid Transporter 1 (B0AT1) (SLC6A19) or the imino acid transporter Sodium-dependent Imino Transporter 1 (SIT1) (SLC6A20), associations that are required for the surface expression of these transport proteins. These heterodimers can form quaternary structures able to function as binding sites for SARS-CoV-2 spike glycoproteins. The heterodimerization of the carboxypeptidase ACE2 with B0AT1 is suggested to favor the direct supply of substrate amino acids to the transporter, but whether this association impacts the ability of ACE2 to mediate viral infection is not known. B0AT1 mutations cause Hartnup disorder, a condition characterized by neutral aminoaciduria and, in some cases, pellagra-like symptoms, such as photosensitive rash, diarrhea, and cerebellar ataxia. Correspondingly, the lack of ACE2 and the concurrent absence of B0AT1 expression in small intestine causes a decrease in l-tryptophan absorption, niacin deficiency, decreased intestinal antimicrobial peptide production, and increased susceptibility to inflammatory bowel disease (IBD) in mice. Thus, the abundant expression of ACE2 in small intestine and its association with amino acid transporters appears to play a crucial role for the digestion of peptides and the absorption of amino acids and, thereby, for the maintenance of structural and functional gut integrity.
Subcortical Involvement in Formulaic Language: Studies on Bilingual Individuals With Parkinson's Disease
Authors: Lee Binna , Van Lancker Sidtis Diana 
Published: November 2020

Purpose
An impoverished production of routinized expressions, namely, formulaic language, has been reported for monolingual speakers with Parkinson's disease (PD). Little is known regarding how formulaic expressions might be manifested in individuals with neurological damage who speak more than one language. This study investigated the processing of formulaic language across first language (L1) and second language (L2) in bilingual individuals with PD.

Method
Eleven Korean–English bilingual speakers with PD, who acquired Korean as L1 and English as L2, were recruited for this study. Two matched control groups composed of 11 healthy Korean–English bilingual individuals and 11 healthy native English speakers were included for comparison. Their performance on three structured tasks (comprehension, completion, and judgment–correction) and conversational speech was measured and compared across groups for analyses.

Results
The bilingual speakers with PD had significantly impaired comprehension of formulaic language in L1 and had lower proportions of formulaic expressions in their L1 conversational speech compared with the bilingual controls. Regarding L2, both bilingual groups with and without PD were comparable in their English performance across all tasks. Both groups performed significantly poorer in L2 structured tasks than the native English speakers. Spontaneous production of formulaic language in English (L2 for bilingual individuals) was similar across all three groups.

Conclusions
The results of this study contribute to the growing body of literature on impoverishment of formulaic language production following subcortical dysfunction. Additionally, findings here demonstrate a selective impairment of formulaic language performance in L1 but not L2 for bilinguals with PD, further supporting the role of the basal ganglia in native language.
Retraction: Servicing the Senior Swallow: A Family-Centered Private Practice Model of Service Delivery
Authors: McCoy Yvette M. 
Published: November 2020

Notice of Retraction

https://doi.org/10.1044/2020_Dec2020ASHA

Purpose
Person-centered care shifts the focus of treatment away from the traditional medical model and moves toward personal choice and autonomy for people receiving health services. Older adults remain a priority for person-centered care because they are more likely to have complex care needs than younger individuals. Even more specifically, the assessment and treatment of swallowing disorders are often thought of in terms of setting-specific (i.e., acute care, skilled nursing, home health, etc.), but the management of dysphagia in older adults should be considered as a continuum of care from the intensive care unit to the outpatient multidisciplinary clinic. In order to establish a framework for the management of swallowing in older adults, clinicians must work collaboratively with a multidisciplinary team using current evidence to guide clinical practice. Private practitioners must think critically not only about the interplay between the components of the evidence-based practice treatment triad but also about the broader impact of dysphagia on caregivers and families. The physical health and quality of life of both the caregiver and the person receiving care are interdependent.

Conclusion
Effective treatment includes consideration of not only the patient but also others, as caregivers play an important role in the recovery process of the patient with swallowing disorders.
Atomic data for the Gaia-ESO Survey
Authors: Heiter U. , Lind K. , Bergemann M. , Asplund M. , Mikolaitis Š. , Barklem P. S. , Masseron T. , de Laverny P. , Magrini L. , Edvardsson B. , Jönsson H. , Pickering J. C. , Ryde N. , Bayo Arán A. , Bensby T. , Casey A. R. , Feltzing S. , Jofré P. , Korn A. J. , Pancino E. , Damiani F. , Lanzafame A. , Lardo C. , Monaco L. , Morbidelli L. , Smiljanic R. , Worley C. , Zaggia S. , Randich S. , Gilmore G. F. 
Published: November 2020

Context. We describe the atomic and molecular data that were used for the abundance analyses of FGK-type stars carried out within the Gaia-ESO Public Spectroscopic Survey in the years 2012 to 2019. The Gaia-ESO Survey is one among several current and future stellar spectroscopic surveys producing abundances for Milky-Way stars on an industrial scale.
Aims. We present an unprecedented effort to create a homogeneous common line list, which was used by several abundance analysis groups using different radiative transfer codes to calculate synthetic spectra and equivalent widths. The atomic data are accompanied by quality indicators and detailed references to the sources. The atomic and molecular data are made publicly available at the CDS.
Methods. In general, experimental transition probabilities were preferred but theoretical values were also used. Astrophysical gf-values were avoided due to the model-dependence of such a procedure. For elements whose lines are significantly affected by a hyperfine structure or isotopic splitting, a concerted effort has been made to collate the necessary data for the individual line components. Synthetic stellar spectra calculated for the Sun and Arcturus were used to assess the blending properties of the lines. We also performed adetailed investigation of available data for line broadening due to collisions with neutral hydrogen atoms.
Results. Among a subset of over 1300 lines of 35 elements in the wavelength ranges from 475 to 685 nm and from 850 to 895 nm, we identified about 200 lines of 24 species which have accurate gf-values and are free of blends in the spectra of the Sun and Arcturus. For the broadening due to collisions with neutral hydrogen, we recommend data based on Anstee-Barklem-O’Mara theory, where possible. We recommend avoiding lines of neutral species for which these are not available. Theoretical broadening data by R.L. Kurucz should be used for Sc II, Ti II, and Y II lines; additionally, for ionised rare-earth species, the Unsöld approximation with an enhancement factor of 1.5 for the line width can be used.
Conclusions. The line list has proven to be a useful tool for abundance determinations based on the spectra obtained within the Gaia-ESO Survey, as well as other spectroscopic projects. Accuracies below 0.2 dex are regularly achieved, where part of the uncertainties are due to differences in the employed analysis methods. Desirable improvements in atomic data were identified for a number of species, most importantly Al I, S I, and Cr II, but also Na I, Si I, Ca II, and Ni I.
Repeating fast radio bursts caused by small bodies orbiting a pulsar or a magnetar
Authors: Mottez Fabrice , Zarka Philippe , Voisin Guillaume 
Published: November 2020

Context.Asteroids orbiting into the highly magnetized and highly relativistic wind of a pulsar offer a favorable configuration for repeating fast radio bursts (FRB). The body in direct contact with the wind develops a trail formed of a stationary Alfvén wave, called an Alfvén wing. When an element of wind crosses the Alfvén wing, it sees a rotation of the ambient magnetic field that can cause radio-wave instabilities. In the observer’s reference frame, the waves are collimated in a very narrow range of directions, and they have an extremely high intensity. A previous work, published in 2014, showed that planets orbiting a pulsar can cause FRBs when they pass in our line of sight. We predicted periodic FRBs. Since then, random FRB repeaters have been discovered.Aims.We present an upgrade of this theory with which repeaters can be explained by the interaction of smaller bodies with a pulsar wind.Methods.Considering the properties of relativistic Alfvén wings attached to a body in the pulsar wind, and taking thermal consideration into account, we conducted a parametric study.Results.We find that FRBs, including the Lorimer burst (30 Jy), can be explained by small-size pulsar companions (1 to 10 km) between 0.03 and 1 AU from a highly magnetized millisecond pulsar. Some parameter sets are also compatible with a magnetar. Our model is compatible with the high rotation measure of FRB 121102. The bunched timing of the FRBs is the consequence of a moderate wind turbulence. An asteroid belt composed of fewer than 200 bodies would suffice for the FRB occurrence rate measured with FRB 121102.Conclusions.After this upgrade, this model is compatible with the properties discovered since its first publication in 2014, when repeating FRBs were still unknown. It is based on standard physics and on common astrophysical objects that can be found in any type of galaxy. It requires 1010times less power than (common) isotropic-emission FRB models.
Ornstein-Uhlenbeck parameter extraction from light curves of Fermi-LAT observed blazars
Authors: Burd Paul R. , Kohlhepp Luca , Wagner Sarah M. , Mannheim Karl , Buson Sara , Scargle Jeffrey D. 
Published: November 2020

Context. Monthly binned γ-ray light curves of 236 bright γ-ray sources, particularly blazars, selected from a sample of 2278 high-galactic latitude objects observed with Fermi-LAT show flux variability characterized by power spectral densities consisting of a single power-law component, ranging from Brownian to white noise.
Aims. The main goal here is to assess the Ornstein-Uhlenbeck (OU) model by studying the range of its three parameters that reproduces these statistical properties.
Methods. We develop procedures for extracting values of the three OU model parameters (mean flux, correlation length, and random amplitude) from time series data and apply them to compare numerical integrations of the OU process with the Fermi-LAT data.
Results. The OU process fully describes the statistical properties of the flux variations of the 236 blazars. The distributions of the extracted OU parameters are narrowly peaked around well-defined values (σ, μ, θ) = (0.2, −8.4, 0.5) with variances (0.004, 0.07, 0.13). The distributions of rise and the decay time scales of flares in the numerical simulations, meaning major flux variations fulfilling pre-defined criteria, are in agreement with the observed ones. The power spectral densities of the synthetic light curves are statistically indistinguishable from those of the measured light curves.
Conclusions. The long-term γ-ray flux variability of blazars on monthly time scales is well described by a stochastic model that involves only three parameters. The methods described here are powerful tools for studying randomness in light curves and thereby for constraining the physical mechanisms responsible for the observed flux variations.