bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review on the systems biology research of Yin‐deficiency‐heat syndrome in traditional Chinese medicine
Authors: Jiang Ting‐Ting , Li Ji‐Cheng 
Published: January 2020

AbstractTraditional Chinese medicine (TCM) is a systematic medical method that has existed for more than 3,000 years. Unlike Western medicine, the disease diagnosis in TCM is carried out by inspection, auscultation, olfaction, interrogation, and palpation. The patient is then treated according to the disease and corresponding TCM syndrome. However, the development of Chinese medicine is stagnated, partially because it can be influenced by subjective factors, such as the experience and knowledge of TCM practitioners, and there is a lack of relevant biological research on TCM syndromes. Yin‐deficiency‐heat (YDH) syndrome in TCM is characterized by a series of pathological changes caused by the insufficiency of Yin‐fluid, inability to moisturize, and the failure to suppress Yang. In recent years, systems biology research on TCM syndromes has gradually become the focus of TCM research, including syndrome differentiation and functional research using systems biology methodologies such as proteomics, transcriptomics, and metabolomics. This journal aims to publish a series of issues on the systems biology research of TCM syndromes that can provide biological indicators for the syndrome differentiation of YDH syndrome and can provide perspectives on the biological research of YDH syndrome.
Relationship between rectal abdominis muscle position and physiological umbilical herniation and return: A morphological and morphometric study
Authors: Ji Xiang , Ishikawa Aoi , Nagata Akari , Yamada Shigehito , Imai Hirohiko , Matsuda Tetsuya , Takakuwa Tetsuya 
Published: January 2020

AbstractThe herniation of the intestinal loop (IL) in the extraembryonic coelom and its return to abdominal cavity is in parallel with the formation of the rectal abdominis muscle (RAM). Using high‐resolution magnetic resonance imaging data of human fetuses (n = 19, CRL22‐69 mm; stored at Kyoto Collection), this study aimed to analyze the relationship between the development of RAM and phase of IL herniation. The RAM runs at the lateral part of the abdominal wall in the small samples in the herniation phase. The position was shifted to the midline area in the larger samples in the herniation phase. According to fetal growth, the caudal ends of the muscles extended along the umbilical ring towards the pubis, though the caudal part of the RAMs were thin and faint in most of the samples. Length measurements related with the growth of the abdominal wall including RAM and abdominal circumference showed positive correlation with fetal growth. On the contrary, diastasis of RAMs and the width and area of the umbilical ring were almost constant according to fetal growth. Such morphometric value showed no obvious changes regardless of the phases of herniation. The ratio of the width and diastasis of the RAMs to the circumference was decreased, indicating that the closure of the ventral body wall was influenced by growth differences. The present data indicate that the formation of the abdominal wall including RAM is independent of the phase of IL herniation, whether in the extraembryonic coelom or in the abdominal cavity.
Bose‐Einstein condensation and antiparticles in a magnetized neutral vector boson gas at any temperature
Authors: de la Caridad Suárez González Lismary , Angulo Gretel Quintero , Martínez Aurora Pérez , Rojas Hugo Pérez 
Published: January 2020

AbstractWe study the thermodynamic properties of a relativistic magnetized neutral vector boson gas at any temperature. We analyze the effect of temperature as well as antiparticles in Bose‐Einstein condensation. Astrophysical implications are discussed.
Investigating the asymptotic proton‐proton cross section at the Large Hadron Collider using parton saturation models and geometric scaling phenomenon
Authors: Machado Magno V. T. 
Published: January 2020

AbstractIn this contribution, we compute the total cross section for proton‐proton collisions at the Large Hadron Collider in the context of quantum chromo dynamics (QCD) parton saturation models presenting geometric scaling phenomenon. Moreover, prediction for pion‐proton total cross section is also provided for asymptotic energies. The main theoretical uncertainties associated to the calculations are discussed.
Kurt Beyers Beitrag zur Baustatik
Authors: Kurrer Karl‐Eugen 
Published: January 2020

AbstractWährend Heinrich Müller‐Breslau (1851–1925) als Vollender der Klassischen Baustatik im letzten Viertel des 19. Jahrhunderts gilt, nahm Kurt Beyer (1881–1952) mit seiner Monografie „Die Statik im Eisenbetonbau“ in der zweiten Hälfte der Konsolidierungsperiode der Baustatik (1900–1950) die nächste und höhere Stufe im disziplinären Maßstab. Beyers Buchwerk über Baustatik ist eine wissenschaftliche Syntheseleistung ersten Ranges, avancierte zum unübertroffenen Handbuch dieser technikwissenschaftlichen Grundlagendisziplin in ihrer Inventionsphase (1925–1950) und wirkte noch weit in die Innovationsphase (1950–1975) hinein.So kann Kurt Beyer als Vollender der klassischen Moderne der Baustatik bezeichnet werden, die hier als integraler Bestandteil der Klassischen Moderne des Ingenieurbaus begriffen wird. Nachfolgend wird dieser Entwicklungsprozess aus Sicht der Biografik sowie der Wissenschafts‐ und Technikgeschichte auf Basis von Archivalien beschrieben und analysiert.
Regressive models for risk prediction of repeated multinomial outcomes: An illustration using Health and Retirement Study data
Authors: Chowdhury Rafiqul I. , Islam Mohammed Ataharul 
Published: January 2020

AbstractLife expectancy is increasing in many countries and this may lead to a higher frequency of adverse health outcomes. Therefore, there is a growing demand for predicting the risk of a sequence of events based on specified factors from repeated outcomes. We proposed regressive models and a framework to predict the joint probabilities of a sequence of events for multinomial outcomes from longitudinal studies. The Markov chain is used to link marginal and sequence of conditional probabilities to predict the joint probability. Marginal and sequence of conditional probabilities are estimated using marginal and regressive models. An application is shown using the Health and Retirement Study data. The bias of parameter estimates for all models from all bootstrap simulation is less than 1% in most of the cases. The estimated mean squared error is also very low. Results from the simulation study show negligible bias and the usefulness of the proposed model. The proposed model and framework would be useful to solve real‐life problems from various fields and big data analysis.
Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database
Authors: Coulon Nathalie , Godin Ophélia , Bulzacka Ewa , Dubertret Caroline , Mallet Jasmina , Fond Guillaume , Brunel Lore , Andrianarisoa Méja , Anderson George , Chereau Isabelle , Denizot Hélène , Rey Romain , Dorey Jean‐Michel , Lançon Christophe , Faget Catherine , Roux Paul , Passerieux Christine , Dubreucq Julien , Leignier Sylvain , Capdevielle Delphine , André Myrtille , Aouizerate Bruno , Misdrahi David , Berna Fabrice , Vidailhet Pierre , Leboyer Marion , Schürhoff Franck 
Published: January 2020

AbstractObjectiveTo compare the clinical symptomatology in patients with Early‐Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551).MethodIn a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years).ResultsThe importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1 and 8.1 years ± 5.7 vs. 1.0 years ± 2.5), more severe symptomatology (PANSS Positive And Negative Syndrome Scale scores), and lower educational level than the AOS group. In addition, the VEOS subgroup had a more frequent childhood history of learning disabilities and lower prevalence of right‐handedness quotient than the AOS.ConclusionThe study demonstrates the existence of an increased gradient of clinical severity from AOS to VEOS. In order to improve the prognosis of the early forms of schizophrenia and to reduce the DUP, clinicians need to pay attention to the prodromal manifestations of the disease.
Evaluation of the diagnostic value of circulating tumor cells with CytoSorter® CTC capture system in patients with breast cancer
Authors: Jin Lidan , Zhao Wenhe , Zhang Jun , Chen Wenjun , Xie Tan , Wang Linbo , Fan Wanhung , Xie Shuduo , Shen Jianguo , Zheng Heming , Hu Wenxian , Wei Qun , Dong Minjun , Wang Qinchun , Shen Jun , Liu Yongcheng 
Published: January 2020

AbstractPurposeIn this study, we aimed to investigate the viability of utilizing CytoSorter® system to detect circulating tumor cells (CTCs) and to evaluate the diagnostic value of CTCs in breast cancer (BC).MethodsA total of 366 females patients suspected of having BC and 30 healthy female volunteers were enrolled in this study. CTCs were enriched by CytoSorter®, a microfluidic‐based CTCs capturing platform. CTC detection was performed before operation or biopsy. Based on the biopsy results, patients were divided into two groups, namely patients with BC and patients with benign breast diseases (BBD). Patients with BBD and healthy volunteers were serving as controls. The correlation between CTC enumeration and patients' clinicopathological characteristics was evaluated. The receiver operating characteristic (ROC) curve was plotted to assess the diagnostic potency of CytoSorter® system in BC.ResultsBased on the biopsy results, 130 BC patients at different cancer stages and 236 patients with BBD were enrolled in the study. Seven subjects were dropped out from the study. CTCs were detected in 109 of 128 BC patients, in one of 29 healthy volunteers, and in 37 of 232 patients with BBD. Maximum CTC counts detected in BC patients, healthy volunteers, and patients with BBD were 8, 1, and 4, respectively. Statistical analysis showed CTCs could be used to distinguish BC patients from healthy volunteers and patients with BBD (P < .0001). Circulating tumor cells were statistically associated with patients' cancer stage (P = .0126), tumor size (tumor node metastasis [TNM] T stage, P = .0253), cancer type (invasive vs noninvasive, P = .0141), and lymph node metastasis (P = .0436). More CTCs were found in patients at advanced cancer stage or TNM T stage and in patients with invasive tumor or lymph node metastasis. Furthermore, CTC detection rates in BC patients at Tis and T1‐4 stages were 50%, 81.67%, 91.07%, 100%, and 100%, respectively. When the CTC cut‐off value was set to 2, the ROC curve gave an area under the curve (AUC) of 0.86 with a specificity and sensitivity of 95.4% and 76.56%, respectively. Taken together, CTCs could be used as a diagnostic aid in assistance of cancer screening and staging.ConclusionCirculating tumor cells were successfully isolated in BC patients using CytoSorter® system. CTCs can be used to differentiate BC patients from the patients with BBD or healthy volunteers, and as a diagnostic aid for early cancer diagnosis and cancer staging.
Clients with different problems are different and questionnaires are not blood tests: A template analysis of psychiatric and psychotherapy clients' experiences of the CORE‐OM
Authors: Paz Clara , Adana‐Díaz Lila , Evans Chris 
Published: January 2020

AbstractAimTo explore the constructions users of mental health services have of outcome and change measures, contrasting those of hospital psychiatric patients with psychotic experiences versus psychotherapy clients in private practice who have not had psychotic experiences.MethodTwenty‐four participants, 12 from each setting, were interviewed about their experiences when answering the Clinical Outcomes in Routine Evaluation‐Outcome Measure. Template analysis was used to analyse transcripts from a pragmatic and contextualist position.FindingsParticipants from both settings understood all the items of the CORE‐OM and generally saw it as useful to assess the psychological distress and to appreciate the progress within the treatment. However, experience of emotions such as sadness and hopelessness, a focus on functioning and an emphasis on impartiality of the person who offers the questionnaire were themes that emerged only for the hospital participants. This is the first study explicitly comparing the experiences of two types of users of mental health care services when answering the CORE‐OM; with the increasing routine use of change measures, reactions of these groups to such measures need to be explored in more detail qualitatively as well as quantitatively. Clinicians in all settings should think carefully about the explanations for the use of change measures, being sure that they address the primary concerns of participants. Scores are not like blood test results, and they arise in the relational context, a construction that includes both local organisational and cultural location.
Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships
Authors: Sayout Ahlam , Ouarhach Aicha , Rabie Reda , Dilagui Ilham , Soraa Nabila , Romane Abderrahmane 
Published: January 2020

AbstractThe genus Lavandula is known for its different uses in traditional medicine. This study is interested in the chemical composition of Lavandulapedunculata subsp.atlantica (Braun‐Blanq.) Romo as well as evaluating its antibacterial potential against multi‐resistant strains. The analysis of Lavandulaatlantica essential oil (LAEO) allows the identification of 47 components representing 93.6 % of all identified. The main constituent of LAEO was camphor (50.4 %), followed by fenchone (14.1 %) and camphene (5.6 %). The antibacterial assays revealed that LAEO was active against all the studied bacteria. A preliminary study of the relationship between certain terpenoids and antibacterial activity was also carried out in order to note the compound(s) that are responsible for LAEO's antibacterial activity. This study showed that the activity of the essential oil may be due to the presence of certain minor compounds such as carvone, considering the presence of the synergistic effect between the essential oil.
Transient receptor potential vanilloid 1 promotes EGFR ubiquitination and modulates EGFR/MAPK signalling in pancreatic cancer cells
Authors: Huang Jin , Liu Jingxue , Qiu Lei 
Published: January 2020

Transient receptor potential vanilloid‐1 (TRPV1) was first identified in sensory neurons, where it was suggested as a therapeutic target for pain relief. Here, we show that TRPV1 is expressed in the pancreatic cancer cell line, PANC‐1; that epidermal growth factor receptor (EGFR) expression is downregulated by overexpression or agonist‐induced activation of TRPV1; and conversely, that EGFR expression is increased after silencing TRPV1. Furthermore, TRPV1 overexpression inhibits cell proliferation and significantly reduces the mRNA levels of two oncogenes, KRAS and AKT2. More importantly, TRPV1 downregulates EGFR levels by inducing EGFR ubiquitination and degradation, which modulate EGFR/MAPK signalling in pancreatic cancer cells. These results illustrate the regulation and mechanism of TRPV1 on EGFR in pancreatic cancer cells and may provide new ideas for the design of novel antitumor drugs targeting EGFR.Significance of the studyWe investigated the effect and mechanism of TRPV1 on EGFR‐mediated proliferation and transformation of pancreatic cancer cells, with the aim of providing new ideas and experimental evidence for the application of strategies that promote EGFR degradation to treat pancreatic cancer.
Stent selection among patients with chronic kidney disease: Results from the NCDR CathPCI Registry
Authors: Feldman Daniel A. , Shroff Adhir R. , Bao Haikun , Curtis Jeptha P. , Minges Karl E. , Ardati Amer K. 
Published: January 2020

AbstractObjectivesThis study sought to define contemporary rates of drug eluting stent (DES) usage in patients with chronic kidney disease (CKD).BackgroundAmong patients with CKD undergoing percutaneous coronary interventions (PCIs), outcomes are superior for those who receive DES compared to those who receive bare metal stents (BMSs). However, perceived barriers may limit the use of DES in this population.MethodsAll adult PCI cases from the NCDR CathPCI Registry involving coronary stent placement between July 1, 2009 and December 31, 2015 were analyzed. The rate of DES usage was then compared among four groups, stratified by CKD stage (I/II, III, IV, and V). Subgroup analysis was conducted based on PCI status and indication. Cases were linked to Medicare claims data to assess 1‐year mortality.ResultsA total of 3,650,333 PCI cases met criteria for analysis. DES usage significantly declined as renal function worsened (83.0%, 79.9%, 75.6%, and 75.6%, respectively, in the four CKD stages; p < .001). DES usage was universally lower across the four groups in the setting of ST‐Elevation Myocardial Infarction (STEMI) (70.6%, 66.5%, 58.7%, 58.0%; p < .001) and higher in the setting of elective PCI (87.6%, 84.9%, 82.3%, 77.9%; p < .0001). DES was associated with improved 1‐year survival, and usage increased over time across each group.ConclusionsDESs are underutilized in patients with advanced renal dysfunction. Although DES usage has increased over time, variation still exists between patients with normal renal function and those with CKD.
Identification of spinal afferent nerve endings in the colonic mucosa and submucosa that communicate directly with the spinal cord: The gut–brain axis
Authors: Spencer Nick J. , Kyloh Melinda A. , Travis Lee , Dodds Kelsi N. 
Published: January 2020

AbstractThe major sensory nerve pathway between the colon and central nervous system (spinal cord and brain) that underlies the gut–brain axis, is via spinal afferent neurons, with cell bodies in dorsal root ganglia (DRG). Our aim was to identify the sensory nerve endings in the colon that arise from single colorectal‐projecting DRG neurons. C57BL/6 mice were anesthetized and lumbosacral L6‐S1 DRG injected with dextran biotin. Mice recovered for 7 days. The whole colon was then removed and stained to visualize single axons and nerve endings immunoreactive to calcitonin gene‐related peptide (CGRP). Single axons arising from DRG were identified in the distal colon and their morphological features and CGRP immunoreactivity characterized. After entering the colon, single axons ramified rostrally or caudally along many rows of myenteric ganglia with little circumferential displacement, giving off varicose endings in multiple ganglia. Nerve endings arising from two classes of colorectal‐projecting DRG neuron were identified. One class was peptidergic neurons that had nerve endings in circular muscle, myenteric ganglia, and submucosa. Another class of nonpeptidergic neurons innervated mucosal crypts, myenteric ganglia, and submucosa. Different morphological types of nerve endings which innervate different anatomical layers of colon can arise from the same axon and sensory neuron in DRG. These findings suggest single peptidergic and nonpeptidergic sensory neurons in DRG are potentially capable of detecting sensory stimuli from different anatomical layers of the colon, via different types of nerve endings.
3D iris model and reader for iris identification
Authors: Cohen Fernand , Sowmithran Sowrirajan , Li Chenxi 
Published: January 2020

SummaryIn the presence of eyelids and eyelashes movement, pupil dilation, poor lighting, blur due to movement during iris image acquisition, and factors that collectively cause distortion in the iris image, 2D image‐based iris identification techniques become limited and might lead to iris misclassification due to the dependency on the image appearance (texture) on the possibly distorted image. To alleviate this problem, we introduce a new 3D iris model and reader based upon which iris identification is performed. Using a set of at least two 2D images taken from different views, a small set of reliable and corresponding salient fiducial points (corner points taken from crypts, corona, and serpentine rings of iris pattern) in the two images are extracted, from which a set of 3D iris salient points are obtained using triangulation. Corresponding salient points in the 2D images are found using the Random Sampling Consensus (RANSAC) algorithm, which is robust in identifying the inlier points that correspond to each other in different views of the iris. From this small and reliable salient point set, a denser (high‐resolution) set of extra salient feature points is constructed at minimum cost using a loop subdivision method that yields corresponding extra salient points in the two images from which a high‐resolution 3D iris model is obtained. The points associated with the 3D high‐resolution model are tessellated to form a high‐resolution triangular mesh with the appearance of a triangular patch in the image imported onto the iris personalized 3D model rendering it a 3D iris surface with appearance. This 3D model construction method allows for a 3D classification of a test iris to one of many possible irises stored in the database. The classification is based on a geometric 3D point cloud error. For cross‐validation, the geometric‐based classification can be augmented by considering a mean squared error (MSE) based on the appearance of corresponding points on the test and base models to further disambiguate between irises with close geometric error values.
Step‐by‐Step Pipeline for the Ecological Analysis of Endophytic Fungi using ITS nrDNA Data
Authors: Montero‐Vargas Maripaz , Escudero‐Leyva Efraín , Díaz‐Valerio Stefani , Chaverri Priscila 
Published: January 2020

AbstractThe nuclear ribosomal DNA internal transcribed spacer (ITS) is accepted as the genetic marker or barcode of choice for the identification of fungal samples. Here, we present a protocol to analyze fungal ITS data, from quality preprocessing of raw sequences to identification of operational taxonomic units (OTUs), taxonomic classification, and assignment of functional traits. The pipeline relies on well‐established and manually curated data collections, namely the UNITE database and the FUNGuild script. As an example, real ITS data from culturable endophytic fungi were analyzed, providing detailed descriptions for every step, parameter, and downstream analysis, and finishing with a phylogenetic analysis of the sequences and assigned ecological roles. This article constitutes a comprehensive guide for researchers that have little familiarity with bioinformatic analysis of essential steps required in further ecological studies of fungal communities. © 2020 by John Wiley & Sons, Inc.Basic Protocol 1: Raw sequencing data processingSupport Protocol: Building a BLAST databaseBasic Protocol 2: Obtaining information from databasesBasic Protocol 3: Phylogenetic analysis