bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy outcomes of Q fever : Prospective follow-up study on Reunion Island
Authors: Mboussou Yoan , Jaubert Julien , Larrieu Sophie , Atiana Laura , Naze Florence , Folio Christine , Randrianaivo Hanitra , Bertolotti Antoine , Picot Sandrine , Robillard Pierre-Yves , Boukerrou Malik , Gérardin Patrick 
Published: November 2019

Abstract
Background Q fever has been associated with perinatal complications. We conducted a prospective follow-up study to assess both the incidence of adverse pregnancy outcomes (APOs) associated with Coxiella burnetii infection and the contribution of Q fever to APOs.
Methods Between May 1 and October 31, 2013, within the regional perinatal health care centre of Saint Pierre, Reunion island, we investigated unexplained miscarriages, stillbirths, preterm births or small-for-gestational age children. Seropositivity for C. burnetii antibodies was defined using indirect immunofluorescence for a phase 2 IgG titre ≥1:64. Acute Q fever was defined for a high phase 2 IgG titre ≥1:256 (compatible with recent or active infection) or the detection of C. burnetii genome in miscarriage products and placentas. Incidence rate ratios (IRR) for Q fever related APOs (taken as a composite outcome or individually) were assessed using Poisson regression models for dichotomous outcomes controlling major confounders.
Results Over a 6-month period, 179 pregnant women suspected or diagnosed with an APO were investigated for Q fever, of whom 118 met the definition for an APO. Of these, 19 were seropositive and 10 presented a profile indicative of an acute infection. For three women with an acute Q fever, the chronology between the onset of infection, the APO (2 miscarriages, 1 preterm birth) and the seroconversion suggested causality in the pathogenesis. The cumulative incidence of Q fever related APOs was estimated between 2.2‰ and 5.2‰, whether causality was required or not. Both C. burnetii exposure and acute Q fever were independently associated with APOs (IRR 1.55, 95% CI 1.31-1.84; IRR 1.47, 95% CI 1.15-1.89, respectively).
Conclusions In the endemic context of Reunion island, acute Q fever may lead to APOs. To limit the burden of Q fever on reproduction, pregnant women should be kept away from farms and avoid direct contact with ruminants.
Association between Severe Unaddressed Dental Needs and Developmental Health at School Entry in Canada: A Cross-sectional Study
Authors: Janus Magdalena , Reid-Westoby Caroline , Lee Catherine , Brownell Marni , Maguire Jonathon L. 
Published: November 2019

Abstract
Background and Objective Dental problems are the most prevalent chronic disease worldwide, with up to half of all kindergarten children having tooth decay. However, there is a lack of evidence of whether unaddressed dental needs (UDNs) are associated with children’s developmental health, a concept reflecting holistic child development - encompassing physical, emotional, and cognitive development. The objective of the current study was to evaluate the relationship between UDNs and developmental health among kindergarten children using the Early Development Instrument (EDI). Methods We examined associations between teacher reported UDNs and developmental vulnerability on the EDI. Children were included in the study if they were enrolled in kindergarten in publicly-funded schools in Canada between 2010 and 2015, had been in the classroom for at least one month, and had no more than 25% of missing items on the questionnaire. Results Among 576,264 children who met inclusion criteria (95.4% of eligible children), 2,465 (0.4%) were identified as having UDNs by their teachers. Children with UDNs had 4.58 to 8.27 times higher odds of being vulnerable on any of the five developmental domains (physical health and well-being, social competence, emotional maturity, language and cognitive development, communication skills and general knowledge), compared to children without UDNs. Conclusion In this study, teacher-reported UDNs were associated with developmental vulnerability in kindergarten children. Teacher reported unmet dental needs in kindergarten children may be a proxy for poor developmental health at school entry, and thus a marker for supporting both children’s oral health and early developmental needs.
Comparison of dental plaque reduction after use of electric toothbrushes with and without QLF-D-applied plaque visualization: A 1-week randomized controlled trial
Authors: Akifusa Sumio , Isobe Ayaka , Kibata Kanako , Oyama Akinori , Oyama Hiroko , Ariyoshi Wataru , Nishihara Tatsuji 
Published: November 2019

Abstract
Background: To evaluate the efficacy of a newly developed electric toothbrush in reducing dental plaque via a quantitative light-induced fluorescence-digital (QLF-D)-applied visualisation system in the brush head.Methods: Participants included 20 adults aged 19 to 28 years. Participants were randomly assigned either (i) an electric toothbrush with a monitor to visualise red-fluorescent dental plaque via a camera built into the brush head (monitor usage group, n = 10) or (ii) an electric toothbrush without a monitor (monitor-non-use group, n = 10). The amount of dental plaque was assessed by personal hygiene performance (PHP) at baseline and 1 week later.Results: In the monitor-usage group, PHP score was significantly lower at the 1-week follow-up than at baseline (6 vs 16; range, 0–12 vs 13–21; P = 0.029). This change was not observed in the monitor-non-use group (14 vs 13; range, 6-21 vs 2-26; P = 0.778). After 1 week, the change in PHP scores in the monitor usage group was significantly greater than that in the monitor non-use group (−10 vs 0; range, -21 to 9 vs -8 to 16; P = 0.021).Conclusions: Our results clearly demonstrate that brushing teeth while looking at a monitor that depicts red-autofluorescent dental plaque via application of QLF-D improved the efficacy of dental-plaque removal relative to brushing teeth without a monitor.
Bismuth Containing Quadruple Therapy versus Tailored Therapy as first-line treatments for Helicobacter pylori infection in a high clarithromycin resistance area
Authors: Bang Byoung Wook , Shin Jong Beom , Ko Eun Jung , Kwon Kye Sook , Shin Yong Woon , Suh Young Ju , Kim Hyungkil , Ko Weonjin 
Published: November 2019

Abstract
Background Increasing clarithromycin resistance has led to the need for an alternative first-line therapy for the eradication of Helicobacter pylori (H. pylori) in Korea, and bismuth containing quadruple therapy (BQT) and tailored therapy (TT) have been proposed as alternative regimens. The aim of this study was to compare the eradication rates of BQT and TT as first-line H. pylori eradication therapies. Methods H. pylori infection was diagnosed using the rapid urease test or dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) during endoscopy. Patients positive for H. pylori were divided into two groups; those tested using the rapid urease test received empirical BQT (the BQT group) whereas those tested by DPO-PCR received TT (the TT group). Eradication rates, adverse events, and overall medical costs, which included diagnostic test and eradication regimen costs, were compared. Results Three hundred and sixty patients were included in the study (TT group 178, BQT group 182). The modified intention-to-treat eradication rates of BQT and TT were 88.2% (142/161) and 80.3% (118/147), respectively (p=0.055), and corresponding eradication rates in the per-protocol population were 88.8% (142/160) and 81.4% (118/145) (p=0.07). Compliance and adverse event rates were similar in the two groups. Average medical costs were $ 90.3 per patient in the TT group and $ 75.5 in the BQT group (p=0.000). Conclusions Empirical BQT and tailored therapy were similar in terms of H. pylori eradication rate, safety, and tolerability, but BQT was more cost-effective.
Validation and evaluation of a common biomarker in human cancers sera protein detected by a monoclonal antibody UNIVMab
Authors: Dandi Manjunath , Kumaraswamy Sunil B , V Shashidhara A , Appaiah Hitesh N , Thomas Anil , BANERJEE SHIBDAS 
Published: November 2019

Abstract
Abstract
Objective:
Management and diagnosis of multiple human cancers remain a challenge and search for a common biomarker are still debatable. We described a method and evaluated the use of monoclonal antibody UNIVMab, to detect the protein (H11) as a common biomarker for all cancer irrespective of grade and origin . H11 protein identified as a unique Hyaluronan binding protein not detected earlier. We applied this test both with ELISA, Western blot, fractionated in anion exchange, cibacron gel exclusion, b-Hyaluronan interaction and HA-Oligo competition from various grades of Human cancers sera and processed for the detection of hyaluronan binding protein H11, reacted with Monoclonal antibody UNIVMab and with b-HA.
Results:
Studies from ELISA, Western blot and b-Hyaluronan interactions showed a definitive positive over-expression of UNIVMab reacted H11 antigen in all fortyfive cancer sera compared to normal sera and can be used as a common biomarker. We believe, UNIVMab detected H11 antigen, a unique hyaluronan binding protein, is a common biomarker for all cancer sera.
Keywords:
ELISA, Western blot, Hyaluronic acid binding protein, H11 (sera antigen), UNIVMab. Common Biomarker, Cancers Sera
Finite Elements Analysis of the Temporomandibular Joint Disc in Patient with Intra-articular Disorders
Authors: Lai Linfeng , Xiong Guofeng , Huang Chenyao , Zhou Fan , Xia Fujian 
Published: November 2019

Abstract
Abstract
Background：Anterior and/or medial displacement of the articular disc or intra-articular disorders( ID) is the most common form of TMJ dysfunction.In the present study,3D finite elements analysis (FEA) models including the maxilla, disc and mandible were established using 3D data registration technology.Methods：Six healthy volunteers and 20 TMD patients were selected.CT and MRI data were collected to build 3D FEA model of mandibular and TMJ disc.Stress distribution with different friction coefficient was measured.Result:Results showed that maximum stress of the lateral articular disc in the normal and pathological models. In the normal model, stress distribution was 2.21,1.56,1.49 MPa with 0.001 0.3 and 0.4 friction coefficient.In ID model,stress distribution is 3.87,7.23,7.77MPa respectively. Conclusion:When the friction coefficient of the side with anterior displacement increased, stress on the disc, condyle and mandible of the opposite side increased. Simultaneously, stress values of the disc, condyle and mandible were higher than those of the normal lateral joint.
Potent antibacterial activity of Dihydydropyrimidine-1,3,5-triazines via inhibition of DNA gyrase and antifungal activity with favourable metabolic profile
Authors: Masih Anup , Shrivastava Jitendra Kumar , Bhat Hans Raj , Singh Udaya Pratap 
Published: November 2019

Abstract
The compounds were tested against panel of three Gram-positive, viz. Staphylococcus aureus, Bacillus subtilis, Bacillus cereus and three Gram-negative bacterial strains viz. Pseudomonas aeruginosa, Escherichia coli, and Proteus vulgaris for determination of their antibacterial efficacy using cefixime as a standard drug. The antibiofilm activities of the compounds were determined against Staphylococcus aureus, and Bacillus subtilis. The most potent compounds 7l amd 7m found bacteriostatic in time kill assay via inhibition of DNA Gyrase enzyme. The metabolic liability of compound 7m was determined using RS-Predictor and MetaPrint 2D React. The antifungal activity against human fungal pathogens was also estimated, where these compounds showed considerable activity in comparison to standard. The in vivo antibacterial activity of compound 7m was also determined using S. aureus induced murine infection model.
Early same-admission laparoscopic cholecystectomy for acute mild biliary pancreatitis: a retrospective study
Authors: lyu yunxiao , Cheng Yunxiao , Wang Bin 
Published: November 2019

Abstract
Background As the standard procedure for the surgical treatment for gallbladder stones, we investigated the controversy surrounding the optimal time for laparoscopic cholecystectomy (LC) for acute mild biliary pancreatitis.Methods This retrospective study included medical records of all patients who were admitted with a diagnosis of acute mild biliary pancreatitis at Dongyang People’s Hospital from July 2011 to June 2018. Main outcomes included perioperative characteristics, length of hospital stay, complications, morbidity, and mortality.Results A total of 119 patients were divided into an early LC group (Group I; 52 patients) and a control group (Group II; 67 patients). The mean age was 60.5 years (range, 30–79 years). Conversion to open cholecystectomy (COC) was performed in 17 patients (6 patients in Group I and 11 patients in Group II, P=0.62). There were no significant differences in terms of estimated blood loss and duration of surgery (P=0.08 and P=0.64, respectively). Bile duct injury (BDI) occurred in one patient from each group. The overall hospital stays in Group I were significantly less than in Group II (10.86±3.21 vs 13.29±4.51, P=0.001). Compared with postoperative bile leakage (P=0.72) and postoperative morbidity (P=0.97) and mortality, there were no significant differences between the groups.Conclusions Early LC during the same admission is safe for acute mild biliary pancreatitis and has the advantage of shortening overall hospital stay. There was no significant increase in COC, BDI, and complications.
Presbyopia Management with Diffractive Phakic Posterior Chamber IOL.
Authors: Bianchi Germán Roberto 
Published: November 2019

Abstract
Background : To evaluate safety and refractive efficiency after posterior chamber diffractive implantable phakic contact lens (IPCL) surgery was performed.Methods: A prospective n on-randomized observational case-series study was performed in 54 myopic eyes from 27 patients who underwent diffractive IPCL surgery. The corneal endothelial cell density (ECD), central corneal thickness (CCT), intra-ocular pressure (IOP), vault, uncorrected distance (UDVA), spherical equivalent (SE) and defocus curve, were evaluated 12 months after implantation of the diffractive IPCL. By slit-lap, the presence of cataract was evaluated during post-operative follow-up. Results: Mean age was 47 ±2.62 years-old. The mean SE decreased from -5.95 ±2.56 D pre-operatively to -0.25 ± 0.25 D at 12 months after surgery . The UDVA achieved was 20/20 in 24.1%, 20/25 in 74.1%, remaining eyes obtained 20/32, and no eye lost lines of vision. The binocular defocus curve was 0.06 ±0.05 logMAR for -3.0 D of defocus, 0.11 ±0.04 logMAR for -1.5 D of defocus and 0.08 ±0.03 logMAR for 0 D of defocus. The mean ECD decrease 1.43% and the mean CCT increase 0.06% at 12 months post-operative, without a statistically significant difference ( p : 0.28 and p : 0.93 respectively). No difference ( p : 0.86) in vault was observed at 6 months vs. 12 months, as well as between IOP measurements ( p : 0.22). Non intra or post-operative complications occurred, and specifically cataract did not develop.Conclusions: Diffractive IPCL was implanted safely. Corneal endothelial CD, CCT, vault and IOP remained stable 12 months after surgery. Visual acuity for distance, intermediate and near sight could be improved without spectacles in myopic population with presbyopia.
Epidemiology characteristics for non-myopic Chinese children aged 6 to 12 years in Jiangsu Province
Authors: Zhang Xiyan , Zhou Yonglin , Yang Jie , Wang Yan , Yang Wenyi , Gao Liuwei , Xiang Yao , Zhang Fengyun 
Published: November 2019

Abstract
Background: We aimed to present epidemiology characteristics including SE value, age, BMI, sex for non-myopic Chinese children after indicating the prevalence of myopia among children aged six to twelve . Based on these we were trying to develop alert values for predicting the future onset of myopia. Methods: All students took part in the ophthalmic examination filled in a questionnaire to provide basic demographic information. We used an autorefractor applying with cycloplegia to obtain spherical equivalent value, and part of their parents filled in a questionnaire of factors related to myopic among children. Results: We finally had 3900 non-myopic observations from 6362 students, and the prevalence of myopia is 38.0% for boys and 39.5% for girls respectively. The average values for SE were 0.5±0.7 for boys and 0.6±0.8 for girls respectively. The mean SE decreased with age in children, and the value of height and BMI took on a stable trend. Alert values for myopia could be set as follows, for children aged six years of age, 0.4-0.6 D for boys and 0.8-1.0 D for girls respectively. For children aged seven years of age, 0.4-0.6 D for boys and 0.3-0.5 D for girls respectively, for children aged eight years, 0.2-0.4 D for boys and 0.3-0.5D for girls, for children aged nine years, 0.2-0.4 D for boys and 0.3-0.4D for girls, 0.1-0.3 D for boys aged ten and 0.3D for girls aged ten years, 0.10-0.3 D for boys aged eleven and -0.3-0.3 D for girls aged eleven years, and for children aged twelve ,-0.1-0.1 D for boys and -0.3-0.1 D for girls aged twelve years. Father’s myopia ( OR:1.22,95%CI:1.01-1.48 ), near work on weekends (OR:2.56,95%CI:1.17-5.61) and outdoor activities (OR:0.68,95%CI:0.54-0.86) had an impact to non-myopic students with myopic alerting. Conclusion: Our study presented an epidemiology description for non-myopic students in Jiangsu Province, and we proposed a series of alert values to provide early warning reference for Chinese children aged six to twelve years. We draw a nomograph to predict the probability of myopia onset and found that family, near work and outdoor activities, had an impact on non-myopic students with myopic alerting.
A novel approach to sample size determination of clinical trials for rare diseases assuming symmetry
Authors: Wang Emma , North Bernard , Sasieni Peter 
Published: November 2019

Abstract
Abstract Background Rare and uncommon diseases are difficult to study in clinical trials due to limited recruitment. If the incidence of the disease is very low, international collaboration can only solve the problem to a certain extent. A consequence is a disproportionately high number of deaths from rare diseases, due to unclear knowledge of the best way to treat patients suffering from these diseases. Hypothesis testing using the conventional Type I error in conjunction with the number of patients who can realistically be enrolled for a rare disease, would cause the trial to be severely underpowered. Methods Our proposed method recognises these pragmatic limitations and suggests a new testing procedure, wherein conclusion of efficacy of one arm is grounded in robust evidence of non-inferiority in the endpoint of interest, and reasonable evidence of superiority, over the other arm. Results Simulations were conducted to illustrate the gains in statistical power compared with conventional hypothesis testing in several statistical settings as well as the example of clinical trials for Merkel cell carcinoma, a rare skin tumour. Conclusions Our proposed analysis method enables conducting clinical trials for rare diseases, potentially leading to better standard of care for patients suffering from rare diseases
Non-steroidal anti-inflammatory drug-induced enteropathy as a major risk factor for small bowel bleeding
Authors: Lim Doo-Ho , Jung Kyoungwon , Lee Seung Bum , Park In Kyu , Cha Hee Jeong , Park Jae Ho , Kim Byung Gyu , Jung Seok Won , Jeong In Du , Kim Jae Hyun , Kim Sung Eun , Moon Won , Park Moo In , Park Seun Ja 
Published: November 2019

Abstract
Background: Small bowel (SB) bleeding has been known to account for 5% of all gastrointestinal (GI) bleeding cases and 80% of obscure GI bleeding cases. Although angioectasia is the common etiology of SB bleeding, non-steroidal anti-inflammatory drug (NSAID)-induced SB lesion is also reported as a major cause in previous studies from the Eastern countries. Herein, we assessed the frequency of NSAID-induced SB lesion in Korean patients with obscure GI bleeding. Methods: We retrospectively analyzed medical records of all consecutive patients aged ≥18 years who underwent capsule endoscopy from March 2018 to February 2019 at Ulsan University Hospital and Kosin University Gospel Hospital. Results: Of the 83 subjects (age, mean ± standard deviation: 59 ± 18 years; age range: 18–84 years; men, n=52; women, n=31), 55 (66.2%) had a clear bloody stool and 28 (33.8%) had a normal stool, but all had iron deficiency anemia. A significantly higher frequency (40 of 51) of ulcerative/erosive lesions was observed in patients with inactive bleeding but visible SB lesions than other causes, and as a result, NSAID-induced enteropathy accounted for 41.7% (25 of 60) of all SB bleeding cases. Conclusions: Contrary to findings of previous studies from the Western countries, ulcerative/erosive lesions were found to have higher occurrence than angioectasia in this study, with an implication of NSAIDs in the etiology of obscure GI bleeding. Aggressive small intestine examination is required for patients with unexplained GI bleeding.
lncRNA_Mdeep: an alignment-free predictor for long non-coding RNAs identification by multimodal deep learning
Authors: Fan Xiao-Nan , Zhang Shao-Wu , Zhang Song-Yao , Ni Jin-Jie 
Published: November 2019

Abstract
Background: Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming. Results: In this study, we present an alignment-free multimodal deep learning framework (namely lncRNA_Mdeep) to distinguish lncRNAs from protein-coding transcripts. LncRNA_Mdeep incorporates three different input modalities (i.e. OFH modality, k-mer modality, and sequence modality), then a multimodal deep learning framework is built for learning the high-level abstract representations and predicting the probability whether a transcript is lncRNA or not.Conclusions: LncRNA_Mdeep achieves 98.73% prediction accuracy in 10-fold cross-validation test on human. Compared with other eight state-of-the-art methods, lncRNA_Mdeep shows 93.12% prediction accuracy independent test on human, which is 0.94%~15.41% higher than that of other eight methods. In addition, the results on 11 cross-species datasets show that lncRNA_Mdeep is a powerful predictor for identifying lncRNAs. The source code can be downloaded from https://github.com/NWPU-903PR/lncRNA_Mdeep.