bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectivizing pandemics: (how) do epidemic histories criss-cross contexts?
Authors: Birn Anne-Emanuelle 
Published: November 2020

AbstractThis article explores a smattering of thematic questions that criss-cross the articles in this special pandemics issue; it signposts some reverberations, overlapping responses, and problematic comparisons currently (mid 2020) being made between past pandemics and the tense experiences (and projections going forward) of COVID-19 across the world. The historical pandemics covered here offer an entry point to a fruitful set of genealogies, chronologies, epidemiologies, trajectories, and imaginaries linked to a host of issues: what makes a pandemic ‘global’? What does a global history perspective bring to the table? How does examining germs and genomes shed light on imperialism as a/the pandemic driver? Where do animals, the environment, and ecology fit in and why are they so often excluded from pandemic histories? What counts as medical humanitarianism when health knowledge, know-how, and cooperation ‘from below’ are sidelined? And what came/comes first: a pandemic or a changed world?
Psychometric Properties of the Measure of Love for Nature
Authors: Pasca Laura , Paniagua David , Aragonés Juan Ignacio 
Published: November 2020

Abstract
Several instruments have been developed to measure the human beings-nature relationship, one of which is the Love and Care for Nature Scale. Three studies were conducted with the aim of analyzing to what extent the construct of love and care for nature, responds to two empirically different dimensions, as well as conducting a psychometric study of the scale. The analysis of construct components showed a large cluster formed by two others (connectedness and well-being), considered “love for nature”, and one two-items cluster referring to “care” (Study 1, n = 51). Considering the “love” items, it was found that ten of the items present adequate psychometric properties (Study 2, n = 1071), and adequate levels of reliability and validity (Study 3, n = 151). Consequently, an appropriate measure of love of nature is established, while an interesting future research line would be to separately study the scale’s two components.
Synchronizing Geomagnetic Field Intensity Records in the Levant Between the 23rd and 15th Centuries BCE: Chronological and Methodological Implications
Authors: Shaar Ron , Bechar Shlomit , Finkelstein Israel , Gallet Yves , Martin Mario A. S. , Ebert Yael , Keinan Jonathan , Gonen Lilach 
Published: November 2020

AbstractArcheomagnetic records are an important source of information on the past behavior of the geomagnetic field. Frequently, however, coeval archeomagnetic intensity (archeointensity) datasets from nearby locations display significant discrepancies, hampering precise reconstruction of high‐resolution secular variation curve. This is the case for the time interval between the later phase of the Early Bronze and the early phase of the Late Bronze Ages (23rd–15th centuries BCE) in the Levant and Mesopotamia. We address the problem by cross‐correlating archeointensity datasets from four major multilayered archeological sites in the southern Levant (Hazor and Megiddo), northern Levant (Ebla), and western Upper Mesopotamia (Mari). We report new archeointensity data, obtained using the Thellier‐IZZI‐MagIC and the Triaxe methods, from six strata at Hazor and four radiocarbon‐dated strata at Megiddo. From 39 pottery fragments, 199 specimens passed our selection criteria, from which we calculated the mean archeointensity for each stratum. To strengthen the comparison of these data with previously published data from Mari and Ebla, obtained using the Triaxe method, we conducted a blind test of the methods that resulted in indistinguishable results or a difference of less than 1 μT. The synchronized compilation, constrained by radiocarbon data from Megiddo, displays a V‐shaped pattern with a prominent minimum of at least 200 years centered around the 18th century BCE. The study highlights the importance of stacking archeomagnetic data obtained by different archeointensity methods only after cross‐testing the methods and ensuring that archeological samples were dated in a consistent manner.
Uplift Mechanism of the Highest Mountains at Eastern Himalayan Syntaxis Revealed by In Situ Dense Gravimetry
Authors: She Yawen , Fu Guangyu 
Published: November 2020

AbstractDense gravity surveys at 408 stations are built around eastern Himalayan syntaxis (EHS). Free‐air gravity anomalies (FGAs) and Bouguer gravity anomalies (BGAs) are obtained based on the in situ data, while the modeled and observed FGAs are merged to increase the accuracy of the gravity anomalies. The variation ranges of FGAs and BGAs are −350–100 and −520 to −320 mGal, respectively. The density structures inversed by the BGAs represent a low‐density zone below the Namche Barwa‐Gyala Peri metamorphic massif. The Moho below the metamorphic massif is significantly shallower than the surrounding areas, and the variation range is between 45 and 75 km. A gravity admittance method is used to study the uplift mechanism of the highest mountains at the EHS. Our result shows that rapid uplift is primarily attributed to the upwelling of the mantle.
Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances
Authors: Vorspan Florence , Icick Romain , Mekdad Nawel , Courtin Cindie , Bloch Vanessa , Bellivier Frank , Laplanche Jean-Louis , Prince Nathalie , Pishalin Dmitry , Firmo Cyril , Blugeon Corinne , Mégarbane Bruno , Marie-Claire Cynthia , Benturquia Nadia 
Published: November 2020

AbstractMotor disturbances strongly increase the burden of cocaine use disorder (CUDs). The objective of our translational study was to identify the genes and biological pathways underlying the tolerance to cocaine-induced motor effects. In a 5-day protocol measuring motor tolerance to cocaine in rats (N = 40), modeling the motor response to cocaine in patients, whole-genome RNA sequencing was conducted on the ventral and dorsal striatum to prioritize a genetic association study in 225 patients with severe CUD who underwent thorough phenotypic (cocaine-induced hyperlocomotion, CIH; and cocaine-induced stereotypies, CIS) and genotypic [571,000 polymorphisms (SNPs)] characterization. We provide a comprehensive description of the rat striatal transcriptomic response to cocaine in our paradigm. Repeated vs. acute cocaine binge administration elicited 27 differentially expressed genes in the ventral striatum and two in the dorsal striatum. One gene, Lrp1b, was differentially expressed in both regions. In patients, LRP1B was significantly associated with both CIS and CIH. CIH was also associated with VPS13A, a gene involved in a severe neurological disorder characterized by hyperkinetic movements. The LRP1B minor allele rs7568970 had a significant protective effect against CIS (558 SNPs, Bonferroni-corrected p = 0.02) that resisted adjustment for confounding factors, including the amount of cocaine use (adjusted beta = −0.965 and −2.35 for heterozygotes and homozygotes, respectively, p < 0.01). Using hypothesis-free prioritization of candidate genes along with thorough methodology in both the preclinical and human analysis pipelines, we provide reliable evidence that LRP1B and VPS13A are involved in the motor tolerance to cocaine in CUD patients, in line with their known pathophysiology.
Alternative splicing landscape of the neural transcriptome in a cytoplasmic-predominant Pten expression murine model of autism-like Behavior
Authors: Thacker Stetson , Sefyi Marilyn , Eng Charis 
Published: November 2020

AbstractAlternative splicing (AS) is a posttranscriptional mechanism regulating gene expression that complex organisms utilize to expand proteome diversity from a comparatively limited set of genes. Recent research has increasingly associated AS with increased functional complexity in the central nervous systems in higher order mammals. This work has heavily implicated aberrant AS in several neurocognitive and neurodevelopmental disorders, including autism. Due to the strong genetic association between germline PTEN mutations and autism spectrum disorder (ASD), we hypothesized that germline PTEN mutations would alter AS patterns, contributing to the pathophysiology of ASD. In a murine model of constitutional mislocalization of Pten, recapitulating an autism-like phenotype, we found significant changes in AS patterns across the neural transcriptome by analyzing RNA-sequencing data with the program rMATS. A few hundred significant alternative splicing events (ASEs) that differentiate each m3m4 genotype were identified. These ASEs occur in genes enriched in PTEN signaling, inositol metabolism, and several other pathways relevant to the pathophysiology of ASD. In addition, we identified expression changes in several splicing factors known to be enriched in the nervous system. For instance, the master regulator of microexons, Srrm4, has decreased expression, and consequently, we found decreased inclusion of microexons in the Ptenm3m4/m3m4 cortex (~10% decrease). We also demonstrated that the m3m4 mutation disrupts the interaction between Pten and U2af2, a member of the spliceosome. In sum, our observations point to germline Pten disruption changing the landscape of alternative splicing in the brain, and these changes may be relevant to the pathogenesis and/or maintenance of PTEN-ASD phenotypes.
Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia
Authors: Rollins Colleen P. E. , Garrison Jane R. , Arribas Maite , Seyedsalehi Aida , Li Zhi , Chan Raymond C. K. , Yang Junwei , Wang Duo , Liò Pietro , Yan Chao , Yi Zheng-hui , Cachia Arnaud , Upthegrove Rachel , Deakin Bill , Simons Jon S. , Murray Graham K. , Suckling John 
Published: November 2020

AbstractAll perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, China (n = 181 combined) and 63 healthy controls from Shanghai. Participants were stratified into those with (n = 79 UK; n = 22 Shanghai) and without (n = 43 UK; n = 37 Shanghai) hallucinations from the PANSS P3 scores for hallucinatory behaviour. We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed cortical folding covariance matrices organized by large-scale functional networks. In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls. Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks. The discovery of neurodevelopmental alterations contributing to hallucinations establishes testable models for these enigmatic, sometimes highly distressing, perceptions and provides mechanistic insight into the pathological consequences of prenatal origins.
Functional validation of CHMP7 as an ADHD risk gene
Authors: Dark Callum , Williams Caitlin , Bellgrove Mark A. , Hawi Ziarih , Bryson-Richardson Robert J. 
Published: November 2020

AbstractAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder of childhood with a strong genetic component. Despite the success of mapping ADHD risk loci, little work has been done to experimentally verify the contribution of these loci to ADHD phenotypes. Meta-analysis of four genome-wide association studies in ADHD suggested CHMP7 as a predisposing gene for ADHD. A DNA variant (rs2294123) mapped to CHMP7 has been shown (via bioinformatic analysis) to have a high likelihood for functionality and correlate with reduced transcript levels. We used CRISPR-Cas9 genome editing to generate a chmp7 zebrafish model for ADHD. chmp7+/− fish showed comparable reductions in mRNA levels to individuals homozygous for the CHMP7 ADHD risk allele. These fish displayed significant hyperactivity over a 24-h period at 6 days post-fertilisation compared to chmp7+/+, but this effect did not persist into juvenile and adulthood stages. In addition, chmp7+/− fish had significantly smaller total brain volumes than chmp7+/+ fish. Finally, the hyperactivity at 6 days post-fertilisation was significantly reduced through the application of methylphenidate, a mainstay pharmacological treatment for ADHD. Overall, this study highlights an important role for CHMP7 in the neurodevelopment of ADHD, and demonstrates the utility of zebrafish for modelling the functional effects of genes conferring risk to ADHD.
PD-L1 degradation pathway and immunotherapy for cancer
Authors: Gou Qian , Dong Chen , Xu Huihui , Khan Bibimaryam , Jin Jianhua , Liu Qian , Shi Juanjuan , Hou Yongzhong 
Published: November 2020

AbstractProgrammed death ligand 1 (PD-L1, CD274) is an essential immune checkpoint protein that binds to programmed death 1 (PD-1) on T-lymphocytes. T cell plays a critical role in killing cancer cells while the cancer cell exhibits immune escape by the expression of PD-L1. The binding of PD-L1 to PD-1 inhibits T cell proliferation and activity, leading to tumor immunosuppression. Increasing evidence shows that PD-L1 protein undergoes degradation in proteasomes or lysosomes by multiple pathways, leading to enhanced immunotherapy for cancer. Although some specific drugs induce PD-L1 degradation and increase antitumor activity, the combination of these drugs with PD-L1/PD-1 blockade significantly enhances cancer immunotherapy. In this review, we have discussed the interaction of PD-L1 degradation with cancer immunotherapy.
Biodegradable, flexible silicon nanomembrane-based NOx gas sensor system with record-high performance for transient environmental monitors and medical implants
Authors: Ko Gwan-Jin , Han Soo Deok , Kim Jeong-Ki , Zhu Jia , Han Won Bae , Chung Jinmook , Yang Seung Min , Cheng Huanyu , Kim Dong-Hwee , Kang Chong-Yun , Hwang Suk-Won 
Published: November 2020

AbstractA novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period of operation offers unprecedented opportunities for medical implants, environmental sensors, and other applications. Here, we describe a biodegradable, flexible silicon-based electronic system that detects NO species with a record-breaking sensitivity of 136 Rs (5 ppm, NO2) and 100-fold selectivity for NO species over other substances with a fast response (~30 s) and recovery (~60 s). The exceptional features primarily depend on not only materials, dimensions, and design layouts but also temperatures and electrical operations. Large-scale sensor arrays in a mechanically pliable configuration exhibit negligible deterioration in performance under various modes of applied loads, consistent with mechanics modeling. In vitro evaluations demonstrate the capability and stability of integrated NOx devices in severe wet environments for biomedical applications.
Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides
Authors: Lin Tingzhi , Gu Yuanyun , Qian Pengcheng , Guan Haixing , Walsh Patrick J. , Mao Jianyou 
Published: November 2020

AbstractThe catalytic generation of homoenolates and their higher homologues has been a long-standing challenge. Like the generation of transition metal enolates, which have been used to great affect in synthesis and medicinal chemistries, homoenolates and their higher homologues have much potential, albeit largely unrealized. Herein, a nickel-catalyzed generation of homoenolates, and their higher homologues, via decarbonylation of readily available cyclic anhydrides has been developed. The utility of nickel-bound homoenolates and their higher homologues is demonstrated by cross-coupling with unactivated alkyl bromides, generating a diverse array of aliphatic acids. A broad range of functional groups is tolerated. Preliminary mechanistic studies demonstrate that: (1) oxidative addition of anhydrides by the catalyst is faster than oxidative addition of alkyl bromides; (2) nickel bound metallocycles are involved in this transformation and (3) the catalyst undergoes a single electron transfer (SET) process with the alkyl bromide.
Application of an analytical framework for multivariate mediation analysis of environmental data
Authors: Aung Max T. , Song Yanyi , Ferguson Kelly K. , Cantonwine David E. , Zeng Lixia , McElrath Thomas F. , Pennathur Subramaniam , Meeker John D. , Mukherjee Bhramar 
Published: November 2020

AbstractDiverse toxicological mechanisms may mediate the impact of environmental toxicants (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. In this study, we introduce an analytical framework for multivariate mediation analysis to identify mediation pathways (q = 61 mediators) in the relationship between environmental toxicants (p = 38 analytes) and gestational age at delivery. Our analytical framework includes: (1) conducting pairwise mediation for unique exposure-mediator combinations, (2) exposure dimension reduction by estimating environmental risk scores, and (3) multivariate mediator analysis using either Bayesian shrinkage mediation analysis, population value decomposition, or mediation pathway penalization. Dimension reduction demonstrates that a one-unit increase in phthalate risk score is associated with a total effect of 1.07 lower gestational age (in weeks) at delivery (95% confidence interval: 0.48–1.67) and eicosanoids from the cytochrome p450 pathway mediated 26% of this effect (95% confidence interval: 4–63%). Eicosanoid products derived from the cytochrome p450 pathway may be important mediators of phthalate toxicity.
High precision epidermal radio frequency antenna via nanofiber network for wireless stretchable multifunction electronics
Authors: Zhang Yufei , Huo Zhihao , Wang Xiandi , Han Xun , Wu Wenqiang , Wan Bensong , Wang Hui , Zhai Junyi , Tao Juan , Pan Caofeng , Wang Zhong Lin 
Published: November 2020

AbstractRecently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information communication. Inspired by natural systems, various patterned Ag nanofibers electrodes with a net structure are fabricated via using lithography and wet etching. The device design is optimized by analyzing the quality factor and radio frequency properties of the coil, considering the effects of strain. Particularly, the wireless transmission efficiency of a five-turn coil drops by approximately only 50% at 10 MHz with the strain of 100%. Moreover, various complex functional wireless electronics are developed using near-field communication and frequency modulation technology for applications in content recognition and long-distance transmission (>1 m), respectively. In summary, the proposed device has considerable potential for applications in artificial electronic skins, human healthcare monitoring and soft robotics.
Historical and projected future range sizes of the world’s mammals, birds, and amphibians
Authors: Beyer Robert M. , Manica Andrea 
Published: November 2020

AbstractSpecies’ vulnerability to extinction is strongly impacted by their geographical range size. Formulating effective conservation strategies therefore requires a better understanding of how the ranges of the world’s species have changed in the past, and how they will change under alternative future scenarios. Here, we use reconstructions of global land use and biomes since 1700, and 16 possible climatic and socio-economic scenarios until the year 2100, to map the habitat ranges of 16,919 mammal, bird, and amphibian species through time. We estimate that species have lost an average of 18% of their natural habitat range sizes thus far, and may lose up to 23% by 2100. Our data reveal that range losses have been increasing disproportionately in relation to the area of destroyed habitat, driven by a long-term increase of land use in tropical biodiversity hotspots. The outcomes of different future climate and land use trajectories for global habitat ranges vary drastically, providing important quantitative evidence for conservation planners and policy makers of the costs and benefits of alternative pathways for the future of global biodiversity.
Nonreciprocal superconducting NbSe2 antenna
Authors: Zhang Enze , Xu Xian , Zou Yi-Chao , Ai Linfeng , Dong Xiang , Huang Ce , Leng Pengliang , Liu Shanshan , Zhang Yuda , Jia Zehao , Peng Xinyue , Zhao Minhao , Yang Yunkun , Li Zihan , Guo Hangwen , Haigh Sarah J. , Nagaosa Naoto , Shen Jian , Xiu Faxian 
Published: November 2020

AbstractThe rise of two-dimensional (2D) crystalline superconductors has opened a new frontier of investigating unconventional quantum phenomena in low dimensions. However, despite the enormous advances achieved towards understanding the underlying physics, practical device applications like sensors and detectors using 2D superconductors are still lacking. Here, we demonstrate nonreciprocal antenna devices based on atomically thin NbSe2. Reversible nonreciprocal charge transport is unveiled in 2D NbSe2 through multi-reversal antisymmetric second harmonic magnetoresistance isotherms. Based on this nonreciprocity, our NbSe2 antenna devices exhibit a reversible nonreciprocal sensitivity to externally alternating current (AC) electromagnetic waves, which is attributed to the vortex flow in asymmetric pinning potentials driven by the AC driving force. More importantly, a successful control of the nonreciprocal sensitivity of the antenna devices has been achieved by applying electromagnetic waves with different frequencies and amplitudes. The device’s response increases with increasing electromagnetic wave amplitude and exhibits prominent broadband sensing from 5 to 900 MHz.
Enhanced fish production during a period of extreme global warmth
Authors: Britten Gregory L. , Sibert Elizabeth C. 
Published: November 2020

AbstractMarine ecosystem models predict a decline in fish production with anthropogenic ocean warming, but how fish production equilibrates to warming on longer timescales is unclear. We report a positive nonlinear correlation between ocean temperature and pelagic fish production during the extreme global warmth of the Early Paleogene Period (62-46 million years ago [Ma]). Using data-constrained modeling, we find that temperature-driven increases in trophic transfer efficiency (the fraction of production passed up trophic levels) and primary production can account for the observed increase in fish production, while changes in predator-prey interactions cannot. These data provide new insight into upper-trophic-level processes constrained from the geological record, suggesting that long-term warming may support more productive food webs in subtropical pelagic ecosystems.