bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monsters and the pantomime
Authors: Marsden Robert 
Published: March 2020

AbstractMonsters within British pantomime are ubiquitous creatures, from the ogre in the castle ofPuss in Bootsto the Giant at the top of the beanstalk, and as personified in the monstrous acts of Wicked Stepmothers, frightening Barons and diabolical henchmen. The popularity of pantomime means that it is often the first encounter that a child has with a monster in material form, sharing the same physical space: a theatre. Bruno Bettelheim (1991) argues that fairytales, from where many pantomimes are drawn, are our first negotiations with the monstrous. In pantomime, the audience are complicit in the act of finding, chasing and dealing with the monster, and the ethical positioning of this by writers and directors is paramount in guiding us to understand how we may deal with the ‘other’ in our own lives. This paper critically interrogates the threat posed by these monsters when invested with a materiality in performance. In the first instance, I explore the interplay between stage space and the representation of the monster and how this relates to my professional experience of directing over twenty-five professional pantomimes in the United Kingdom since 1999. Tracing this spatial dynamic between monster and audience to the medieval stage and the ludic dimension to the staging of the devils in the mystery play, the paper argues that there is a long-reaching historical antecedent to the staging of evil that informs and inspires spatial practices in modern-day pantomime. Key questions are: to what extent have pantomimes historically presented and rehearsed the threat posed by the monster in order to contain that threat?; What ethical considerations do producers, writers and directors now face in the contemporary pantomime? Finally, to what extent does the popular form of pantomime itself matter as a vehicle for enabling audiences both young and old to confront the monstrous Other?
Possibility for inhibited spontaneous emission in electromagnetically open parity–time-symmetric guiding structures
Authors: Hadad Yakir , Engheta Nader 
Published: March 2020

Significance
Energy conservation implies that in lossless systems with prohibited radiation, spontaneous emission (the process in which an excited atom returns to its ground state while emitting a photon) is inhibited. However, since radiation is forbidden, electromagnetic sensing and far-field manipulation of the quantum emitter are challenging tasks. We suggest to resolve this issue by using a parity–time-symmetric waveguide system with balanced gain and loss. We theoretically show that the power emitted by a classical dipole in this system may be nullified while dipole excitation frequency is well inside the structure’s passband. In light of known relations connecting spontaneous emission of quantum emitters and classical dipole radiation, our results establish a possibility for inhibited spontaneous emission in electromagnetically open systems.
Study on substitution of Ni with Ni3Al on structure and properties of W–6Ni3Al–4Co alloys by two-step sintering process
Authors: Dong Hongfeng , Li Peiyou , Ai Taotao , Li Wenhu 
Published: March 2020

Abstract
Herein, the effect of substitution of Ni with Ni3Al and two-step sintering on the phase transformation, microstructure evolution, and properties of W–6Ni–4Co alloys were evaluated. The results show that the reaction products of Ni3Al and Co include (Ni, Co)3Al4 to Co2Al9 during the two-step sintering process. When Ni was substituted by Ni3Al, the densification temperature was reduced. The distribution of W phase turned from stripes to network, and the grain size increased with an increase in the sintering temperature. The Ni3Al substituted sample sintered at 1500 °C for 20 min displayed a combination of high densification parameter, microhardness, and strength because of denser microstructure of the alloy.
HLPpred-Fuse: improved and robust prediction of hemolytic peptide and its activity by fusing multiple feature representation
Authors: Hasan Md Mehedi , Schaduangrat Nalini , Basith Shaherin , Lee Gwang , Shoombuatong Watshara , Manavalan Balachandran 
Published: March 2020

Abstract

Motivation
Therapeutic peptides failing at clinical trials could be attributed to their toxicity profiles like hemolytic activity, which hamper further progress of peptides as drug candidates. The accurate prediction of hemolytic peptides (HLPs) and its activity from the given peptides is one of the challenging tasks in immunoinformatics, which is essential for drug development and basic research. Although there are a few computational methods that have been proposed for this aspect, none of them are able to identify HLPs and their activities simultaneously.

Results
In this study, we proposed a two-layer prediction framework, called HLPpred-Fuse, that can accurately and automatically predict both hemolytic peptides (HLPs or non-HLPs) as well as HLPs activity (high and low). More specifically, feature representation learning scheme was utilized to generate 54 probabilistic features by integrating six different machine learning classifiers and nine different sequence-based encodings. Consequently, the 54 probabilistic features were fused to provide sufficiently converged sequence information which was used as an input to extremely randomized tree for the development of two final prediction models which independently identify HLP and its activity. Performance comparisons over empirical cross-validation analysis, independent test and case study against state-of-the-art methods demonstrate that HLPpred-Fuse consistently outperformed these methods in the identification of hemolytic activity.

Availability and implementation
For the convenience of experimental scientists, a web-based tool has been established at http://thegleelab.org/HLPpred-Fuse.

Contact
glee@ajou.ac.kr or watshara.sho@mahidol.ac.th or bala@ajou.ac.kr

Supplementary information
Supplementary data are available at Bioinformatics online.
Simultaneous Determination of Eight Components in Leonuri Herba from Different Habitats by HPLC-DAD
Authors: Xu Yang , Yang Huailei , Chi Jihong , Wang Fang , Bao Huiwei 
Published: March 2020

Abstract
A HPLC-DAD method was established for the simultaneous determination of eight components in Leonuri Herba from different habitats, as well as providing methodological reference for quality control of Leonuri Herba. In this study, absolute ethanol extracts of the medicinal material were considered as the sample solutions to be analyzed. Agilent ZORBAX SB-C18 column (250 mm × 4.6 mm, 5 μm) was used for determination maintained at the temperature of 30°C. Gradient elution was performed with a mobile phase of methanol (B)-0.1% phosphoric acid solution (A) at the flow rate of 1.0 mL·min−1. The analysis was carried out at the wavelength of 225, 280 and 320 nm. The measured eight components showed good linear relationships within their own concentration range. Average recoveries ranged from 98.83 to 100.36% with RSDs of 1.14~1.97%. The proposed method was found to be simple, accurate and reproducible, which provided an effective quantitative analytical method for quality control of Leonuri Herba from different habitats.
Perinatal Transmission of 2019 Coronavirus Disease–Associated Severe Acute Respiratory Syndrome Coronavirus 2: Should We Worry?
Authors: Fan Cuifang , Lei Di , Fang Congcong , Li Chunyan , Wang Ming , Liu Yuling , Bao Yan , Sun Yanmei , Huang Jinfa , Guo Yuping , Yu Ying , Wang Suqing 
Published: March 2020

AbstractWe present 2 cases of coronavirus disease 2019 (COVID-19)–associated severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the third trimester of pregnancy. Both mothers and newborns had excellent outcomes. We failed to identify SARS-CoV-2 in all of the products of conception and the newborns. This report provided evidence of low risk of intrauterine infection by vertical transmission of SARS-CoV-2.
Echocardiographic reference ranges for normal left ventricular layer-specific strain: results from the EACVI NORRE study
Authors: Tsugu Toshimitsu , Postolache Adriana , Dulgheru Raluca , Sugimoto Tadafumi , Tridetti Julien , Nguyen Trung Mai-Linh , Piette Caroline , Moonen Marie , Manganaro Roberta , Ilardi Federica , Chitroceanu Alexandra Maria , Sperlongano Simona , Go Yun Yun , Kacharava George , Athanassopoulos George D , Barone Daniele , Baroni Monica , Cardim Nuno , Hagendorff Andreas , Hristova Krasimira , Lopez Teresa , de la Morena Gonzalo , Popescu Bogdan A , Penicka Martin , Ozyigit Tolga , Rodrigo Carbonero Jose David , van de Veire Nico , Von Bardeleben Ralph Stephan , Vinereanu Dragos , Zamorano Jose Luis , Rosca Monica , Calin Andreea , Magne Julien , Cosyns Bernard , Galli Elena , Donal Erwan , Santoro Ciro , Galderisi Maurizio , Badano Luigi P , Lang Roberto M , Lancellotti Patrizio 
Published: March 2020

Abstract

Aims
To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages.

Methods and results
A total of 287 (109 men, mean age: 46 ± 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as ±1.96 standard deviations from the mean were −15.0% in men and −15.6% in women for epicardial strain, −16.8% and −17.7% for mid-myocardial strain, and −18.7% and −19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = −0.20, P = 0.007, mid-myocardial; r = −0.21, P = 0.006, endocardial; r = −0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 ± 0.2, middle; 1.2 ± 0.1, base 1.1 ± 0.1) and women (apex; 1.6 ± 0.1, middle; 1.1 ± 0.1, base 1.2 ± 0.1).

Conclusion
The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.
Ice(berg) Transport Costs
Authors: Bosker Maarten , Buringh Eltjo 
Published: March 2020

Abstract
Iceberg transport costs are a key ingredient of modern trade and economic geography models. Using detailed information on Boston’s nineteenth-century global ice trade, we show that the cost of shipping the only good that truly melts in transit is not well-proxied by this assumption. Additive cost components account for the largest part of per unit ice(berg) transport costs in practice. Moreover, the physics of the melt process and the practice of insulating the ice in transit meant that shipping ice is subject to economies of scale. This finding supports, from an unexpected historical angle, recent efforts to incorporate more realistic features of the transportation sector in trade and economic geography models.
Honesty and Self-Selection into Cheap Talk
Authors: Fehrler Sebastian , Fischbacher Urs , Schneider Maik T 
Published: March 2020

ABSTRACT
In many situations, people can lie strategically, for their own benefit. Since individuals differ with respect to their willingness to lie, the credibility of statements will crucially depend on who self-selects into such cheap-talk situations. We study this process in a two-stage political competition setting. At the entry stage, potential candidates compete in a contest to become their party’s candidate in an election. At the election stage, the nominated candidates campaign by making promises to voters. Confirming the model’s key prediction, we find in our experiment that dishonest people over-proportionally self-select into the political race and thereby lower voters’ welfare.
The Struggle between Nationalist and Jihadist Narratives of Gallipoli, 1915–2015
Authors: Aktar Ayhan 
Published: March 2020

Abstract
There have been a number of milestones in the (re-)writing of the history of the Gallipoli campaign (1915). First, the dominant Turkish nationalist historiography ‘Turkified’ the victory of the Ottoman Imperial Army. Narratives of the 1930s were also constructed in such a way that the presence of Mustafa Kemal (later Atatürk) was used as a bridge to attach the Gallipoli campaign of 1915 to the Turkish War of Independence (1919–1922). In later years, Islamist poets such as Mehmet Akif wrote poems presenting the campaign as a kind of ‘Resistance of Islam against the Infidel’. However, it was not until the mid-1990s that the Gallipoli campaign came to be framed as an ‘Invasion of Crusaders into the House of Islam’. This new narrative reflects a jihadist revision. In this article, these trends will be analysed within the framework of operations of political power in both civil society and the state.
Comparative proteomics analysis of Tibetan hull-less barley under osmotic stress via data-independent acquisition mass spectrometry
Authors: Wang Yulin , Sang Zha , Xu Shaohang , Xu Qijun , Zeng Xingquan , Jabu Dunzhu , Yuan Hongjun 
Published: March 2020

Abstract

Background
Tibetan hull-less barley (Hordeum vulgare L. var. nudum) is one of the primary crops cultivated in the mountains of Tibet and encounters low temperature, high salinity, and drought. Specifically, drought is one of the major abiotic stresses that affect and limit Tibetan barley growth. Osmotic stress is often simultaneously accompanied by drought conditions. Thus, to improve crop yield, it is critical to explore the molecular mechanism governing the responses of hull-less barley to osmotic/drought stress conditions.

Findings
In this study, we used quantitative proteomics by data-independent acquisition mass spectrometry to investigate protein abundance changes in tolerant (XL) and sensitive (DQ) cultivars. A total of 6,921 proteins were identified and quantified in all samples. Two distinct strategies based on pairwise and time-course comparisons were utilized in the comprehensive analysis of differentially abundant proteins. Further functional analysis of differentially abundant proteins revealed that some hormone metabolism–associated and phytohormone abscisic acid–induced genes are primarily affected by osmotic stress. Enhanced regulation of reactive oxygen species (may promote the tolerance of hull-less barley under osmotic stress. Moreover, we found that some regulators, such as GRF, PR10, MAPK, and AMPK, were centrally positioned in the gene regulatory network, suggesting that they may have a dominant role in the osmotic stress response of Tibetan barley.

Conclusions
Our findings highlight a subset of proteins and processes that are involved in the alleviation of osmotic stress. In addition, this study provides a large-scale and multidimensional proteomic data resource for the further investigation and improvement of osmotic/drought stress tolerance in hull-less barley or other plant species.
18 Stop the Burn: A Smoking and Home Oxygen Safety Initiative with Use of Firebreaks
Authors: Mastropieri Cynthia J , Leonard Ginger , Holmes James H 
Published: March 2020

Abstract

Introduction
COPD is a chronic pulmonary disease treated with home oxygen. The single most common cause of COPD is cigarette smoking. Approximately 1.4 million people in the US use long-term oxygen therapy for treatment of hypoxic COPD. Smoking is an addictive risky behavior and smoking on oxygen therapy is responsible for the majority of home oxygen fires and deaths. Up to 52% of patients who use oxygen therapy continue to smoke in spite of these risks. At least 1,000 burn injuries per year occur when oxygen cannula tips ignite after coming in close contact with cigarettes, lighters, or matches. Flames travel externally and internally along the tubing toward the oxygen concentrator, which can explode. Previous prevention efforts have focused on counseling and education of patients and their caregivers; however, the habit continues, causing burn injury admissions and increasing health care costs.

Methods
Our ABA verified burn center admitted 90 burn injuries during July 2015 to September 2019 related to smoking on oxygen. Given the mechanism of injury, further preventive efforts were researched, and firebreak devices were identified as a secondary preventive measure to attempt to reduce negative consequences of smoking on oxygen. A firebreak device is fitted in the oxygen tubing near the patient and also near the oxygen concentrator. The firebreak acts as a thermal fuse by stopping the oxygen supply when triggered, preventing the flames from burning to the oxygen concentrator. Our program goal was to develop a safety initiative using educational information and firebreak devices. Information was shared at the regional Trauma committee and with local EMS, Fire and on Facebook. The program was initiated in 2018. We worked with local EMS and Fire agencies to install the firebreak devices in nursing homes, assisted living facilities and in patients’ homes who use oxygen.

Results
Our program distributed 225 firebreak kits, which included no smoking signs, a home oxygen safety checklist, an educational video link, nasal cannula tubing and 2 firebreak devices. Since the initiation of the program, the number of burn injury admissions from smoking on oxygen decreased from an average of 24/year to an average of 9/year.

Conclusions
Standardizing the use of firebreak kits in the community for those smoking on oxygen or using oxygen stops a fire by halting the oxygen supply thereby potentially decreasing burn admissions. Therefore, we recommend the consideration of firebreak kits for patients who continue to smoke while using oxygen to Stop the Burn.

Applicability of Research to Practice
Future research is recommended to determine the effectiveness of firebreak kits as a safety measure for all individuals who use oxygen.
24 Geospatial Localization of Adult Burn Injuries and Associated Housing Factors in a Major Urban Metropolis
Authors: Chandramouli Mathangi A , Mount Lauren , Winchell Robert , Chang Philip 
Published: March 2020

Abstract

Introduction
According to the National Burn Repository, almost 75% of all burns occur at the burn victim’s home. The modern urban metroplex is a diverse ecosystem made up of varied socioeconomic backgrounds often housed under heterogenous living conditions. We sought to better understand the relationship between location of injury and socioeconomic factors using geospatial mapping for this patient population.

Methods
Injury Zip Code Data was obtained from the electronic medical record of an ABA verified Burn Center serving a major urban metropolis from 2016–2018. Data was also obtained from this city’s OpenData database and included housing vacate list data from the fire department of this city, fire department dispatch data, fire department firehouse listing, fire department active order violation, and housing maintenance code complaints. ArcGIS software was used to create and analyze hotspot maps (p&lt; 0.05).

Results
GIS analysis revealed a statistically significant relationship between number of burns (NB) and firehouse density per zip code in sparsely distributed patches around NYC (Fig. 1) (p&lt; 0.05). Notably, there is a statistically significant relationship between NB and fire dispatch volume as well as a large cluster of statistically significant area with respect to NB and housing active code violations in the two most populous districts (Fig 2 and 3) (p&lt; 0.01).

Conclusions
Certain housing factors such as building code violations relate to burn volume in certain areas. It is also noted that increased firehouse density and fire dispatch volume are associated a larger volume of burn occurrences. Further analysis of different housing and social factors are is anticipated.

Applicability of Research to Practice
Burn outreach efforts are tailored towards our unique population. Having a better understanding of the population and localizing areas with increased burn injuries along with the potential social factors can help direct future outreach and prevention efforts.
62 Impact of the Affordable Care Act on Post-discharge Services After Burn Injury
Authors: Godat Laura N , Higginson Sara , Lee Jeanne , Doucet Jay , Costantini Todd W 
Published: March 2020

Abstract

Introduction
Recovery from burn injury is a prolonged process often requiring post-discharge services such as rehabilitation or skilled nursing care. Affordable Care Act Open Enrollment (ACA-OE) began in January 2014 providing access to medical insurance for millions of previously uninsured Americans. Whether improved insurance coverage has improved access to post-discharge care for patients admitted with burn injury is unknown. We hypothesized that the ACA would improve insurance coverage for patients admitted with burn injury and that medical insurance would be associated with increased access to post-discharge care services.

Methods
The Nationwide Readmission Database was queried to identify patients ages 18–65 with an index admission for cutaneous burn injury using ICD-9 & ICD-10 codes. Patients with Medicare or those that died during the index admission were excluded. Pre-ACA-OE admissions (2013, Q1-Q3) were compared with post-ACA admissions (2016, Q1-Q3) to evaluate the effects the ACA-OE of insurance status, length of stay, discharge disposition, 30- and 90-day readmission rates.

Results
There were 12,932 burn-injured patients included with 5,389 patients in 2013 and 7,543 patients in 2016. Post-ACA, Medicaid insurance increased from 33.0% to 43.9% (p&lt; 0.001) while self-pay decreased from 25.8% to 13.7% (p&lt; 0.001). Private insurance status did not change after implementation of the ACA (41.2% vs. 42.4%). Post-ACA-OE, overall routine discharge home decreased from 79.4% to 77.7% (p=0.02) while discharge to a care facility increased from 7.2% to 8.7% (p=0.002). Length of stay was not different between groups (8.9 ± 15.9 days vs. 9.0 ± 15.5 days). Medicaid patients had the highest readmission rates at 30- and 90-days (see Figure). Medicaid patients had decreased 90-day non-elective readmission rates post-ACA-OE (22.4% to 20.0%, p=0.041). Predictors of non-elective 90-day readmission were Medicaid insurance (OR 2.06, CI 1.76–2.40, p&lt; 0.001) and older age (OR 1.03, CI 1.02–1.03, p&lt; 0.001).

Conclusions
The ACA-OE increased access to insurance for burn patients. Discharges to care facilities after burn injury increased post-ACA-OE and was associated with decreased 90-day readmission. Ongoing advocacy efforts are need to improve access to post-burn care resources to optimize recovery from injury.

Applicability of Research to Practice
Awareness of the impacts of health policy and insurance coverage on access to post-discharge resources and readmission rates after burn injury.