bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study of partial replacement of cement by waste marble powder in a concrete prepared with artificial sand
Authors: Korabu I , Pise C 
Published: June 2020

Abstract
Marble is the most common building material having a huge amount of waste. This waste causes dust pollution also it makes soil infertile etc. Day by day marble waste goes on increasing. Another problem is regarding no availability of natural sand as resources of natural sand exhausting very rapidly also it contains a lot of deleterious materials to overcome this issue we can make partial replacement of cement by waste marble powder and natural sand by artificial sand. The concrete is made with heterogeneous material therefore compressive strength of concrete depends upon various materials with various trials. so the process is simplified in a mathematical technique called the regression method, which gives predicted compressive strength, if we get regression equation, it reduces the trials of concrete mix.
A review on microstructures and properties of high entropy alloys manufactured by selective laser melting
Authors: Zhang Chen , Zhu Junkai , Zheng Huai , Li Hui , Liu Sheng , Cheng Gary J 
Published: June 2020

Abstract
High entropy alloys (HEAs) with multi-component solid solution microstructures have the potential for large-scale industrial applications due to their excellent mechanical and functional properties. However, the mechanical properties of HEAs limit the selection of processing technologies. Additive manufacturing technology possesses strong processing adaptability, making itthe best candidate method to overcome this issue. This comprehensive review examines the current state of selective laser melting (SLM) of HEAs. Introducing SLM to HEAs processing is motivated by its high quality for dimensional accuracy, geometric complexity, surface roughness, and microstructure. This review focuses on analyzing the current developments and challenges in SLM of HEAs, including defects, microstructures, and properties, as well as strengthing prediction models of fabricated HEAs. This review also offers directions for future studies to address existing challenges and promote technological advancement.
Special needs of frail people undergoing emergency laparotomy surgery
Authors: McCarthy Kathryn , Hewitt Jonathan 
Published: June 2020

Abstract
There are now over 30 000 emergency laparotomies under taken in the UK every year, a figure that is increasing year on year. Over half of these people are aged over 70 years old. Frailty is commonly seen in this population and becomes increasingly common with age and is seen in over 50% of elderly emergency laparotomies in people aged over 85 years old. In older people who undergo surgery one third will have died within one year of surgery, a figure which is worse in frail individuals. For those that do survive, post-operative morbidity is worse and 30% of frail older people do not return to their own home. In the UK, the National Emergency Laparotomy Audit (NELA) is leading the way in providing the evidence base in this population group. Beyond collecting data on every Emergency Laparotomy undertaken in the UK, it is also key in driving improvement in care. Their most recent report highlights that only 23% of patients over 70 years received geriatric involvement following surgery. More encouragingly, the degree of multidisciplinary geriatric involvement seems to be increasing. In the research setting, well designed studies focusing on the older frail emergency laparotomy patient are underway. It is anticipated that these studies will better define outcomes following surgery, improving the communication and decision making between patients, relatives, carers and their surgical teams.
Importance of previous hospital stays on the risk of hospital re-admission in older adults: a real-life analysis of the PAERPA study population
Authors: Visade Fabien , Babykina Genia , Lamer Antoine , Defebvre Marguerite-Marie , Verloop David , Ficheur Grégoire , Genin Michael , Puisieux François , Beuscart Jean-Baptiste 
Published: June 2020

Abstract

Background
consideration of the first hospital re-admission only and failure to take account of previous hospital stays, which are the two significant limitations when studying risk factors for hospital re-admission. The objective of the study was to use appropriate statistical models to analyse the impact of previous hospital stays on the risk of hospital re-admission among older patients.

Methods
an exhaustive analysis of hospital discharge and health insurance data for a cohort of patients participating in the PAERPA (‘Care Pathways for Elderly People at Risk of Loss of Personal Independence’) project in the Hauts de France region of France. All patients aged 75 or over were included. All data on hospital re-admissions via the emergency department were extracted. The risk of unplanned hospital re-admission was estimated by applying a semiparametric frailty model, the risk of death by applying a time-dependent semiparametric Cox regression model.

Results
a total of 24,500 patients (median [interquartile range] age: 81 [77–85]) were included between 1 January 2015 and 31 December 2017. In a multivariate analysis, the relative risk (95% confidence interval [CI]) of hospital re-admission rose progressively from 1.8 (1.7–1.9) after one previous hospital stay to 3.0 (2.6–3.5) after five previous hospital stays. The relative risk [95%CI] of death rose slowly from 1.1 (1.07–1.11) after one previous hospital stay to 1.3 (1.1–1.5) after five previous hospital stays.

Conclusion
analyses of the risk of hospital re-admission in older adults must take account of the number of previous hospital stays. The risk of death should also be analysed.
Carbon assimilation through a vertical light gradient in the canopy of invasive herbs grown under different temperature regimes is determined by leaf and whole-plant architecture
Authors: Jorgensen Andreas , Sorrell Brian K , Eller Franziska 
Published: June 2020

AbstractThis study examined the acclimation to temperature of two globally invasive species Iris pseudacorus and Lythrum salicaria, which share the same habitat type but differ in morphology. Iris pseudacorus has long vertical leaves, allowing light penetration through the canopy, while L. salicaria has stems with small horizontal leaves, creating significant self-shading. We aimed to build a physiological understanding of how these two species respond to different growth temperatures with regard to growth and gas exchange-related traits over the canopy. Growth and gas exchange-related traits in response to low (15 °C) and high (25 °C) growth temperature regimes were compared. Plants were grown in growth chambers, and light response curves were measured with infrared gas analysers after 23–33 days at three leaf positions on each plant, following the vertical light gradient through the canopy. After 37 days of growth, above-ground biomass, photosynthetic pigments and leaf N concentration were determined. The maximum photosynthesis rate was lower in lower leaf positions but did not differ significantly between temperatures. Iris pseudacorus photosynthesis decreased with decreasing leaf position, more so than L. salicaria. This was explained by decreasing N and chlorophyll concentrations towards the leaf base in I. pseudacorus, while pigment concentrations increased towards the lower canopy in L. salicaria. Biomass, shoot height and specific leaf area increased with temperature, more so in I. pseudacorus than in L. salicaria. Light response curves revealed that L. salicaria had a higher degree of shade acclimation than I. pseudacorus, probably due to self-shading in L. salicaria. High temperature decreased C assimilation at the bottom of the canopy in L. salicaria, while C assimilation in I. pseudacorus was less affected by temperature. As vegetative growth and flowering was stimulated by temperature, the invasive potential of these species is predicted to increase under global warming.
Morphological characterization of flight feather shafts in four bird species with different flight styles
Authors: Osváth Gergely , Vincze Orsolya , David Dragomir-Cosmin , Nagy László Jácint , Lendvai Ádám Z , Nudds Robert L , Pap Péter L 
Published: June 2020

AbstractVariation in rachis (central shaft) morphology in individual remiges (flight feathers) within and among species reflects adaptations to requirements imposed by aerodynamic forces, but the fine-scale variation of feather morphology across remiges is not well known. Here we describe how the shape of the rachis, expressed by the height/width ratio, changes along the longitudinal and lateral axis of the wing in four bird species with different flight styles: flapping-soaring (white storks), flapping-gliding (common buzzards), passerine-type (house sparrows) and continuous flapping (pygmy cormorants). Overall, in each wing feather, irrespective of species identity, rachis shape changed from circular to rectangular, from the base towards the feather tip. The ratio between the height and width of the calamus was similar across remiges in all species, whereas the ratio at the base, middle and tip of the rachis changed among flight feathers and species. In distal primaries of white storks and common buzzards, the ratio decreased along the feather shaft, indicating a depressed (wider than high) rachis cross section towards the feather tip, whereas the inner primaries and secondaries became compressed (higher than wide). In house sparrows, the rachis was compressed in each of the measurement points, except at the distal segment of the two outermost primary feathers. Finally, in pygmy cormorants, the width exceeds the height at each measurement point, except at the calamus. Our results may reflect the resistance of the rachis to in-plane and out-of-plane aerodynamic forces that vary across remiges and across study species. A link between rachis shape and resistance to bending from aerodynamic forces is further indicated by the change of the second moment of areas along the wing axes.
Jeffreys-prior penalty, finiteness and shrinkage in binomial-response generalized linear models
Authors: Kosmidis Ioannis , Firth David 
Published: June 2020

SummaryPenalization of the likelihood by Jeffreys’ invariant prior, or a positive power thereof, is shown to produce finite-valued maximum penalized likelihood estimates in a broad class of binomial generalized linear models. The class of models includes logistic regression, where the Jeffreys-prior penalty is known additionally to reduce the asymptotic bias of the maximum likelihood estimator, and models with other commonly used link functions, such as probit and log-log. Shrinkage towards equiprobability across observations, relative to the maximum likelihood estimator, is established theoretically and studied through illustrative examples. Some implications of finiteness and shrinkage for inference are discussed, particularly when inference is based on Wald-type procedures. A widely applicable procedure is developed for computation of maximum penalized likelihood estimates, by using repeated maximum likelihood fits with iteratively adjusted binomial responses and totals. These theoretical results and methods underpin the increasingly widespread use of reduced-bias and similarly penalized binomial regression models in many applied fields.
Imperceptible Somatosensory Single Pulse and Pulse Train Stimulation Oppositely Modulate Mu Rhythm Activity and Perceptual Performance
Authors: Iliopoulos Fivos , Taskin Birol , Villringer Arno , Nierhaus Till 
Published: June 2020

Abstract
Subliminal stimulation alters conscious perception – a potential mechanism is the modulation of cortical background rhythms especially in the alpha range. Here, in the human somatosensory domain, we assessed effects of subthreshold (imperceptible) electrical finger nerve stimulation – either presented as single pulses or as brief (1 s) 7 Hz pulse trains—on mu-alpha rhythm and perceptual performance. In electroencephalography, subthreshold single pulses transiently (~150–350 ms poststimulus) increased mu activity (event-related synchronization), while, interestingly, subthreshold trains led to prolonged (&gt;1 s) mu desynchronization. In psychophysics, detection of near-threshold target stimuli was consistently reduced when presented together with subthreshold trains (at three delays), whereas for targets paired with subthreshold single pulses detection remained unaffected (30 and 180 ms) or was even elevated (60 ms). Though both imperceptible, single pulses and pulse trains exerted opposite effects on neural signaling and perception. We suggest that the common neural basis is preferential activation of cortical inhibitory interneurons. While the inhibitory impact of a subthreshold single pulse (reflected by mu synchronization) is not psychophysically detectable—rather perception may be facilitated—repetition of the same subthreshold pulse shifts the excitation-inhibition balance toward an inhibitory cortical state (reflected by perceptual impediment) accompanied by mu desynchronization. These differential findings provide novel insights on the notion of alpha activity mediating functional inhibition.
Assessing the Feasibility of Typhoid Elimination
Authors: Stanaway Jeffrey D , Atuhebwe Phionah L , Luby Stephen P , Crump John A 
Published: June 2020

Abstract
In 1993, the International Task Force on Disease Eradication classified the political will for typhoid eradication as “none.” Here we revisit the Task Force’s assessment in light of developments in typhoid vaccines and increasing antimicrobial resistance in Salmonella Typhi that have served to increase interest in typhoid elimination. Considering the requisite biological and technical factors for elimination, effective interventions exist for typhoid, and humans are the organism’s only known reservoir. Improvements in water supply, sanitation, hygiene, and food safety are critical for robust long-term typhoid control, and the recent Strategic Advisory Group of Experts on Immunization recommendation and World Health Organization prequalification should make typhoid conjugate vaccine more accessible and affordable in low-income countries, which will allow the vaccine to offer a critical bridge to quickly reduce burden. While these developments are encouraging, all current typhoid diagnostics are inadequate, having either poor performance characteristics, limited scalability, or both. No clear solution exists, and this should be viewed as a critical challenge to any elimination effort. Moreover, asymptomatic carriers and limited data and surveillance remain major challenges, and countries considering elimination campaigns will need to develop strategies to identify high-risk populations and to monitor progress over time. Finally, policymakers must be realistic in planning, learn from the planning failures of previous elimination and eradication efforts, and expect unforeseeable shocks and setbacks. In the end, if we assume neither unanticipated breakthroughs in typhoid control nor any chaotic shocks, history suggests that we should expect typhoid elimination to take decades.
Posterior Oropharyngeal Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Authors: Wong Sally Cheuk Ying , Tse Herman , Siu Hon Kei , Kwong Tsz Shan , Chu Man Yee , Yau Felix Yat Sun , Cheung Ingrid Yu Ying , Tse Cindy Wing Sze , Poon Kin Chiu , Cheung Kwok Chi , Wu Tak Chiu , Chan Johnny Wai Man , Cheuk Wah , Lung David Christopher 
Published: June 2020

AbstractBackgroundThe coronavirus disease 2019 (COVID-19) pandemic has put tremendous pressure on the healthcare system worldwide. Diagnostic testing remained one of the limiting factors for early identification and isolation of infected patients. This study aimed to evaluate posterior oropharyngeal saliva (POPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection among patients with confirmed or suspected COVID-19.MethodsThe laboratory information system was searched retrospectively for all respiratory specimens and POPS requested for SARS-CoV-2 RNA detection between 1 February 2020 and 15 April 2020. The agreement and diagnostic performance of POPS against NPsp were evaluated.ResultsA total of 13772 specimens were identified during the study period, including 2130 POPS and 8438 nasopharyngeal specimens (NPsp). Two hundred and twenty-nine same-day POPS-NPsp paired were identified with POPS and NPsp positivity of 61.5% (95% confidence interval [CI] 55.1–67.6%) and 53.3% (95% CI 46.8–59.6%). The overall, negative and positive percent agreement were 76.0% (95% CI 70.2–80.9%), 65.4% (95% CI 55.5–74.2%), 85.2% (95% CI 77.4–90.8%). Better positive percent agreement was observed in POPS-NPsp obtained within 7 days (96.6%, 95% CI 87.3–99.4%) compared with after 7 days of symptom onset (75.0%, 95% CI 61.4–85.2%). Among the 104 positive pairs, the mean difference in Cp value was 0.26 (range: 12.63 to −14.74), with an overall higher Cp value in NPsp (Pearson coefficient 0.579). No significant temporal variation was noted between the 2 specimen types.ConclusionsPOPS is an acceptable alternative specimen to nasopharyngeal specimen for the detection of SARS-CoV-2.
Concordance of Early and Late End Points for Community-acquired Bacterial Pneumonia Trials
Authors: Bart Stephen M , Nambiar Sumathi , Gopinath Ramya , Rubin Daniel , Farley John J 
Published: June 2020

Abstract

Background
While there are ongoing regulatory convergence efforts, differences remain in primary end points recommended for community-acquired bacterial pneumonia (CABP) trials. The US Food and Drug Administration (FDA) recommends assessing CABP symptom resolution at an early time point (3–5 days after randomization). Other regulatory agencies recommend assessing overall clinical response at a later time point (5–10 days after therapy ends).

Methods
We analyzed participant-level data from 6 recent CABP trials submitted to the FDA (n = 4645 participants) to evaluate concordance between early and late end-point outcomes. We used multivariate logistic regression to identify factors associated with discordance.

Results
Early and late end-point outcomes were concordant for 85.6% of participants. The proportions of early end-point responders that ultimately failed and early end-point nonresponders that ultimately succeeded were similar (6.0% vs 8.4%, respectively). Early end-point response was highly predictive of late end-point success (positive predictive value, 92.9%). Multivariate logistic regression identified early end-point responders/late end-point failures as less likely to be obese and more likely to be infected with Chlamydophila pneumoniae or Staphylococcus aureus, have received antibacterial drug therapy prior to randomization, and have severe chest pain at baseline. The most common investigator-provided reasons for failure among early end-point responders/late end-point failures were receipt of nonstudy antibacterial drug therapy and loss to follow-up.

Conclusions
Early and late end-point outcomes were highly concordant. These data may be useful in the continuing efforts to reach international regulatory convergence on CABP clinical trial design recommendations.
Periprocedural anticoagulation in the uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation (ELIMINATE-AF) trial
Authors: Hohnloser Stefan H , Camm A John , Cappato Riccardo , Diener Hans-Christoph , Heidbüchel Hein , Mont Lluís , Morillo Carlos A , Lanz Hans-Joachim , Rauer Heiko , Reimitz Paul-Egbert , Smolnik Rüdiger , Kautzner Josef 
Published: June 2020

Abstract

Aims
This post hoc analysis of ELIMINATE-AF evaluated requirements of unfractionated heparin (UFH) and procedure-related bleeding in atrial fibrillation (AF) patients undergoing ablation with uninterrupted edoxaban or vitamin K antagonist (VKA) therapy.

Methods and results
Patients were randomized 2:1 to once-daily edoxaban 60 mg (or dose-reduced 30 mg) or dose-adjusted VKA (target international normalized ratio: 2.0–3.0). Uninterrupted anticoagulation was mandated for 21–28 days’ pre-ablation and 90 days’ post-ablation. During ablation, UFH administration targeted an activated clotting time (ACT) of 300–400 s. Periprocedural bleeding was differentiated between procedure-related (bleeding at puncture side, cardiac tamponade) and unrelated events. Of 614 randomized patients, 553 received study drug and underwent catheter ablation (edoxaban n = 375; VKA n = 178). The median (Q1–Q3) time from last dose to ablation procedure was 14.8 (13.3–16.5) vs. 16.5 (14.8–19.5) h (edoxaban vs. VKA group, respectively). Mean ACT (SD) ≥300 s was observed in 52% edoxaban- vs. 76% VKA-treated patients, despite a higher mean (SD) UFH dose in the edoxaban vs. VKA group [14 261 (6397) IU vs. 11 473 (4300) IU; exploratory P-value &lt; 0.0001]. In the edoxaban group, 13 patients (3.5%) had procedure-related bleeds of whom 9 had received an UFH dose above the median (13 000 IU). In the VKA arm, 7 patients (3.9%) had procedure-related bleeds of whom 3 had received an UFH dose above the median (10 225 IU).

Conclusion
The rate of procedure-related major/clinically relevant non-major bleeding did not differ between the treatment arms despite higher doses of UFH used with edoxaban vs. VKA to achieve a target ACT during AF ablation.
Divergent biotic and abiotic filtering of root endosphere and rhizosphere soil fungal communities along ecological gradients
Authors: Lumibao Candice Y , Kimbrough Elizabeth R , Day Richard H , Conner William H , Krauss Ken W , Van Bael Sunshine A 
Published: June 2020

ABSTRACT
Plant roots assemble in two distinct microbial compartments: the rhizosphere (microbes in soil surrounding roots) and the endosphere (microbes within roots). Our knowledge of fungal community assembly in these compartments is limited, especially in wetlands. We tested the hypothesis that biotic factors would have direct effects on rhizosphere and endosphere assembly, while abiotic factors would have direct and indirect effects. Using a field study, we examined the influences of salinity, water level and biotic factors on baldcypress (Taxodium distichum) fungal communities. We found that endosphere fungi, unlike rhizosphere fungi, were correlated with host density and canopy cover, suggesting that hosts can impose selective filters on fungi colonizing their roots. Meanwhile, local abiotic conditions strongly influenced both rhizosphere and endosphere diversity in opposite patterns, e.g. highest endosphere diversity (hump-shaped) and lowest rhizosphere diversity (U-shaped) at intermediate salinity levels. These results indicate that the assembly and structure of the root endosphere and rhizosphere within a host can be shaped by different processes. Our results also highlight the importance of assessing how environmental changes affect plant and plant-associated fungal communities in wetland ecosystems where saltwater intrusion and sea level rise are major threats to both plant and fungal communities.