bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of mixed‐gas adsorption equilibria from pure component adsorption isotherms
Authors: Tun Hla , Chen Chau‐Chyun 
Published: April 2020

AbstractUsing only a single binary interaction parameter per adsorbate‐adsorbate pair, the adsorption nonrandom two‐liquid theory successfully correlates binary gas adsorption experimental data and predicts multicomponent gas adsorption equilibria. This work estimates the binary adsorbate–adsorbate interaction parameters from pure component isotherms and shows very promising agreement with the binary interaction parameters identified from regression of binary gas adsorption data. The results support the feasibility to predict binary and multicomponent gas adsorption equilibria from pure component isotherms for various adsorbents including silica gel, activated carbon, zeolites, and metal–organic frameworks.
High rate of profound clonal and renal responses with daratumumab treatment in heavily pre‐treated patients with light chain (AL) amyloidosis and high bone marrow plasma cell infiltrate
Authors: Milani Paolo , Fazio Francesca , Basset Marco , Berno Tamara , Larocca Alessandra , Foli Andrea , Riva Marcello , Benigna Francesca , Oliva Stefania , Nuvolone Mario , Rodigari Lara , Petrucci Maria Teresa , Merlini Giampaolo , Palladini Giovanni 
Published: April 2020

AbstractDaratumumab demonstrated activity in the treatment of AL amyloidosis in two recently concluded phase II clinical trials in relapsed and refractory patients. Its role in upfront therapy is under evaluation in a phase III study. In this report we evaluated the safety and efficacy of 28‐day cycles of daratumumab (single agent or combined with bortezomib or lenalidomide) in 72 previously treated patients with multiple myeloma and AL amyloidosis. Fifty (69%) were refractory to the last line of therapy. After eight infusions of daratumumab, 59 patients (82%) achieved a hematologic response, with 12 (16%) complete responses (CRs) and 30 (42%) very good partial responses (VGPRs). After 16 infusions, the quality of response improved with 22 patients (30%) achieving CR and 21 (29%) attaining VGPR. Cardiac response was observed in 11 of 37 evaluable patients (29%) and renal response in 23 of 38 patients (60%). Daratumumab is highly effective in heavily pretreated patients with relapsed/refractory AL amyloidosis and high bone marrow plasma cell burden. Renal responses, which are usually rare in this setting, were frequently observed.
Cystic fibrosis transmembrane conductance regulator function, not TAS2R38 gene haplotypes, predict sinus surgery in children and young adults with cystic fibrosis
Authors: Dalesio Nicholas M. , Aksit Melis A. , Ahn Kwangmi , Raraigh Karen S. , Collaco Joseph M. , McGrath‐Morrow Sharon , Zeitlin Pamela L. , An Steven S. , Cutting Garry R. 
Published: April 2020

BackgroundChronic rhinosinusitis symptomatology begins in early childhood individuals with cystic fibrosis (CF). Cystic fibrosis transmembrane conductance regulator (CFTR) function contributes to sinus development and disease. Genetic variants of the bitter taste receptor TAS2R38 have been suggested to contribute to sinus disease severity in individuals without CF. Our objective was to explore whether functional TAS2R38 haplotypes and CFTR function are associated with sinus disease or the need for sinus surgery in individuals with CF.MethodsWe conducted a retrospective study using prospectively collected data from the CF Twin‐Sibling Study. The function of CFTR was assessed via chloride conductance. Genotyping of the TAS2R38 gene identified patients who were homozygous for the functional haplotype, heterozygous, or homozygous for nonfunctional haplotypes. Clustered multivariate logistic regression was performed, controlling for sex and family relationship.ResultsA total of 1291 patients were evaluated. Patients with ≤1% CFTR function were 1.56 times more likely to require sinus surgery than those with >1% CFTR function (p = 0.049). CFTR function did not correlate significantly with the presence of sinus disease (p = 0.30). In addition, there were no statistically significant differences in diagnosis of sinus disease or need for sinus surgery between patients with functional and nonfunctional TAS2R38 haplotypes.ConclusionCFTR function correlates with need for sinus surgery, whereas TAS2R38 function does not appear to contribute to sinus disease or the need for sinus surgery in patients with CF.
Olfactory dysfunction from acute upper respiratory infections: relationship to season of onset
Authors: Potter Mark R. , Chen Jonathan H. , Lobban Nina‐Simone , Doty Richard L. 
Published: April 2020

BackgroundAcute viral upper respiratory tract infections are the most common cause of chronic olfactory dysfunction. In light of the seasonality of numerous viruses, the question arises as to whether the frequency and magnitude of postviral olfactory disorders (PVODs) are similarly seasonal. We sought to determine whether olfactory deficits due to influenza and non–influenza‐related viruses (I‐PVODs and NI‐PVODs) vary in frequency or magnitude across seasons in a North American population and whether they are more prevalent or produce more severe olfactory dysfunction during colder months when host susceptibility may be increased.MethodsThis was a retrospective study of 587 patients presenting to an academic smell and taste center with either I‐PVOD–related or NI‐PVOD–related olfactory deficits. Chi‐square and analysis of covariance (age = covariate) compared dysfunction prevalence frequencies and scores on the University of Pennsylvania Smell Identification Test (UPSIT) across calendar months and between months with the coldest and warmest air temperatures.ResultsFor I‐PVOD–related cases, both the prevalence and magnitude of smell dysfunction were highest in the colder months. However, for NI‐PVOD–related cases, prevalence was higher in warmer months but, paradoxically, the magnitude of dysfunction was higher in colder months.ConclusionThis study shows that seasonal variations occur in both the prevalence and magnitude of PVOD‐related olfactory deficits in a North American population, and that such variations differ between NI‐PVOD and I‐PVOD cases. The findings suggest multiple viruses are involved in producing PVOD‐related olfactory deficits.
Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study
Authors: Lopes Alves Isadora , Collij Lyduine E. , Altomare Daniele , Frisoni Giovanni B. , Saint‐Aubert Laure , Payoux Pierre , Kivipelto Miia , Jessen Frank , Drzezga Alexander , Leeuwis Annebet , Wink Alle Meije , Visser Pieter Jelle , van Berckel Bart N.M. , Scheltens Philip , Gray Katherine R. , Wolz Robin , Stephens Andrew , Gismondi Rossella , Buckely Christopher , Gispert Juan Domingo , Schmidt Mark , Ford Lisa , Ritchie Craig , Farrar Gill , Barkhof Frederik , Molinuevo José Luis ,   the AMYPAD Consortium
Published: April 2020

AbstractIntroductionThe Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) Prognostic and Natural History Study (PNHS) aims at understanding the role of amyloid imaging in the earliest stages of Alzheimer's disease (AD). AMYPAD PNHS adds (semi‐)quantitative amyloid PET imaging to several European parent cohorts (PCs) to predict AD‐related progression as well as address methodological challenges in amyloid PET.MethodsAMYPAD PNHS is an open‐label, prospective, multi‐center, cohort study recruiting from multiple PCs. Around 2000 participants will undergo baseline amyloid positron emission tomography (PET), half of whom will be invited for a follow‐up PET 12 at least 12 months later.ResultsPrimary include several amyloid PET measurements (Centiloid, SUVr, BPND, R1), and secondary are their changes from baseline, relationship to other amyloid markers (cerebrospinal fluid and visual assessment), and predictive value of AD‐related decline.Expected ImpactDetermining the role of amyloid PET for the understanding of this complex disease and potentially improving secondary prevention trials.
Associations of urinary 8‐iso‐prostaglandin F2α levels with all‐cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study
Authors: Trares Kira , Gào Xīn , Perna Laura , Rujescu Dan , Stocker Hannah , Möllers Tobias , Beyreuther Konrad , Brenner Hermann , Schöttker Ben 
Published: April 2020

AbstractIntroductionProspective studies on a potential association of 8‐iso‐prostaglandin F2α (8‐iso‐PGF2α) levels, a biomarker of lipid peroxidation, with dementia are limited.MethodsMultivariate Cox regression models were used to assess potential associations of urinary 8‐iso‐PGF2α levels with all‐cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population‐based cohort.ResultsOver 14 years of follow‐up, 365 all‐cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8‐iso‐PGF2α tertile had a 45% increased risk of all‐cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8‐iso‐PGF2α levels were statistically significantly associated with all‐cause dementia and AD incidence.DiscussionOxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8‐iso‐PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
Premortem Chronic Traumatic Encephalopathy Diagnoses in Professional Football
Authors: Grashow Rachel , Weisskopf Marc G. , Baggish Aaron , Speizer Frank E. , Whittington Alicia J. , Nadler Lee , Connor Ann , Keske Robyn , Taylor Herman , Zafonte Ross , Pascual‐Leone Alvaro 
Published: April 2020

ObjectiveAmerican‐style football (ASF) has gained attention because of possible links between repetitive head injury and neurodegenerative diseases. Although postmortem pathologic changes consistent with chronic traumatic encephalopathy (CTE) have been reported in ASF players, there are currently no established premortem diagnostic criteria for CTE. Nevertheless, presented with symptoms of cognitive impairment, clinicians treating former players may be inclined to suggest CTE without a thorough exploration of comorbid factors that demonstrate similar clinical phenotypes to putative CTE.MethodsA survey of 3,913 former ASF players aged 24 to 89 was conducted for those who responded by March 2019.ResultsDespite being a postmortem diagnosis, 108 players (2.8%) self‐reported clinician‐diagnosed CTE. The percentage of players under age 60 years reporting a CTE diagnosis was 2.3% versus 3.7% in participants age 60 or older. Comorbidities in participants self‐reporting CTE were significantly more common, including sleep apnea, hypercholesterolemia, obesity, indicators of past or current depression, hypertension, prescription pain medication use, heart conditions, and low testosterone when compared to non‐CTE respondents. Patterns of reporting for obesity, hypertension, heart conditions, or hypercholesterolemia differed between older and younger participants. Cognitive impairment symptoms were significantly higher in participants self‐reporting CTE.InterpretationSome former professional football players have been clinically diagnosed with CTE, a postmortem condition. Comorbidities that can affect cognition were associated with CTE diagnoses in both older and younger players. Although underlying neuropathology cannot be ruled out, treatable conditions should be explored in former athletes demonstrating CTE‐linked clinical phenotypes or symptoms as a means of improving cognitive health in these patients. ANN NEUROL 2020 ANN NEUROL 2020;88:106–112
Electrocatalytic Reduction of CO2 to Acetic Acid by a Molecular Manganese Corrole Complex
Authors: De Ratnadip , Gonglach Sabrina , Paul Shounik , Haas Michael , Sreejith S. S. , Gerschel Philipp , Apfel Ulf‐Peter , Vuong Thanh Huyen , Rabeah Jabor , Roy Soumyajit , Schöfberger Wolfgang 
Published: April 2020

AbstractThe controlled electrochemical reduction of carbon dioxide to value added chemicals is an important strategy in terms of renewable energy technologies. Therefore, the development of efficient and stable catalysts in an aqueous environment is of great importance. In this context, we focused on synthesizing and studying a molecular MnIII‐corrole complex, which is modified on the three meso‐positions with polyethylene glycol moieties for direct and selective production of acetic acid from CO2. Electrochemical reduction of MnIII leads to an electroactive MnII species, which binds CO2 and stabilizes the reduced intermediates. This catalyst allows to electrochemically reduce CO2 to acetic acid in a moderate acidic aqueous medium (pH 6) with a selectivity of 63 % and a turn over frequency (TOF) of 8.25 h−1, when immobilized on a carbon paper (CP) electrode. In terms of high selectivity towards acetate, we propose the formation and reduction of an oxalate type intermediate, stabilized at the MnIII‐corrole center.
Dinitrosyl Iron Complex [K‐18‐crown‐6‐ether][(NO)2Fe(MePyrCO2)]: Intermediate for Capture and Reduction of Carbon Dioxide
Authors: Tseng Yu‐Ting , Ching Wei‐Min , Liaw Wen‐Feng , Lu Tsai‐Te 
Published: April 2020

AbstractContinued efforts are made for the utilization of CO2 as a C1 feedstock for regeneration of valuable chemicals and fuels. Mechanistic study of molecular (electro‐/photo‐)catalysts disclosed that initial step for CO2 activation involves either nucleophilic insertion or direct reduction of CO2. In this study, nucleophilic activation of CO2 by complex [(NO)2Fe(μ‐MePyr)2Fe(NO)2]2− (2, MePyr=3‐methylpyrazolate) results in the formation of CO2‐captured complex [(NO)2Fe(MePyrCO2)]− (2‐CO2, MePyrCO2=3‐methyl‐pyrazole‐1‐carboxylate). Single‐crystal structure, spectroscopic, reactivity, and computational study unravels 2‐CO2 as a unique intermediate for reductive transformation of CO2 promoted by Ca2+. Moreover, sequential reaction of 2 with CO2, Ca(OTf)2, and KC8 established a synthetic cycle, 2 → 2‐CO2 → [(NO)2Fe(μ‐MePyr)2Fe(NO)2] (1) → 2, for selective conversion of CO2 into oxalate. Presumably, characterization of the unprecedented intermediate 2‐CO2 may open an avenue for systematic evaluation of the effects of alternative Lewis acids on reduction of CO2.
Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers
Authors: Church Derek C. , Pokorski Jonathan K. 
Published: April 2020

AbstractCell‐based therapies are gaining prominence in treating a wide variety of diseases and using synthetic polymers to manipulate these cells provides an opportunity to impart function that could not be achieved using solely genetic means. Herein, we describe the utility of functional block copolymers synthesized by ring‐opening metathesis polymerization (ROMP) that can insert directly into the cell membrane via the incorporation of long alkyl chains into a short polymer block leading to non‐covalent, hydrophobic interactions with the lipid bilayer. Furthermore, we demonstrate that these polymers can be imbued with advanced functionalities. A photosensitizer was incorporated into these polymers to enable spatially controlled cell death by the localized generation of 1O2 at the cell surface in response to red‐light irradiation. In a broader context, we believe our polymer insertion strategy could be used as a general methodology to impart functionality onto cell‐surfaces.
Light‐Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII‐Aryl Complex
Authors: Yang Liu , Lu Huan‐Huan , Lai Chu‐Hui , Li Gang , Zhang Wei , Cao Rui , Liu Fengyi , Wang Chao , Xiao Jianliang , Xue Dong 
Published: April 2020

AbstractA highly effective C−O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcohols is reported. Catalyzed by a NiII‐aryl complex under long‐wave UV (390–395 nm) irradiation in the presence of a soluble amine base without any additional photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcohols, affording synthetically important ethers. Intramolecular C−O coupling is also possible. The reaction appears to proceed via a NiI–NiIII catalytic cycle.
Adsorption Site Regulation to Guide Atomic Design of Ni–Ga Catalysts for Acetylene Semi‐Hydrogenation
Authors: Cao Yueqiang , Zhang Hao , Ji Shufang , Sui Zhijun , Jiang Zheng , Wang Dingsheng , Zaera Francisco , Zhou Xinggui , Duan Xuezhi , Li Yadong 
Published: April 2020

AbstractAtomic regulation of metal catalysts has emerged as an intriguing yet challenging strategy to boost product selectivity. Here, we report a density functional theory‐guided atomic design strategy for the fabrication of a NiGa intermetallic catalyst with completely isolated Ni sites to optimize acetylene semi‐hydrogenation processes. Such Ni sites show not only preferential acetylene π‐adsorption, but also enhanced ethylene desorption. The characteristics of the Ni sites are confirmed by multiple characterization techniques, including aberration‐corrected high‐resolution scanning transmission electron microscopy and X‐ray absorption spectrometry measurements. The superior performance is also confirmed experimentally against a Ni5Ga3 intermetallic catalyst with partially isolated Ni sites and against a Ni catalyst with multi‐atomic ensemble Ni sites. Accordingly, the NiGa intermetallic catalyst with the completely isolated Ni sites shows significantly enhanced selectivity to ethylene and suppressed coke formation.
Analysis of Copenhagen problem with a repulsive quasi‐homogeneous Manev‐type potential within the frame of variable mass
Authors: Suraj Md Sanam , Mittal Amit , Kaur Charanpreet , Aggarwal Rajiv 
Published: April 2020

AbstractThe present problem is devoted to the special case of restricted problem of three bodies, always referred as the Copenhagen problem when we consider the primaries of equal masses. In this manuscript, we have considered the third body of infinitesimal mass as variable and moreover, instead of taking only Newtonian potential and forces, a quasi‐homogeneous potential produced by the main primaries has also been taken into account. This implies that, in order to approximate the phenomena such as the radiation pressure or the primaries' nonsphericity, we insert an inverse cube corrective term to the gravitational law of inverse square. In this model, the impact of the parameters, arise as a result of variable mass on the number and locations of the in‐plane and out‐of‐plane equilibrium points, is discussed. Moreover, their stability is also analyzed and the impact of these parameters on the regions, where motion of the third particle is possible, is unveiled. The basins of convergence associated with these equilibrium points are also illustrated by the Newton–Raphson iterative scheme of two or more variables.
Flexible Solid‐State Asymmetric Supercapacitors with Enhanced Performance Enabled by Free‐Standing MXene−Biopolymer Nanocomposites and Hierarchical Graphene−RuOx Paper Electrodes
Authors: Qin Leiqiang , Tao Quanzheng , Liu Lianlian , Jiang Jianxia , Liu Xianjie , Fahlman Mats , Hou Lintao , Rosen Johanna , Zhang Fengling 
Published: April 2020

AbstractTwo‐dimensional (2D) transition metal carbides and carbonitrides, called MXenes, with metallic conductivity and hydrophilic surfaces, show great promise as electrode materials for supercapacitors. A major drawback of 2D nanomaterials is the re‐stacking of the nanosheets, which prevents full utilization of surface area and blocks the access of the electrolyte. In this study, a free‐standing nanocomposite paper electrode is realized by combining Mo1.33C MXene and positively charged biopolymer lignin (the second most abundant biopolymer in nature, L‐DEA). The self‐assembled layered architecture with alternating polymer and MXene flakes increases the interlayer space to promote ion transport, and with combining charge storage capability of the lignin derivative and MXene in an interpenetrating MXene/L‐DEA nanocomposite, which offers an impressive capacitance of 503.7 F g−1. Moreover, we demonstrate flexible solid‐state asymmetric supercapacitors (ASCs) using Mo1.33C@L‐DEA as the negative electrode and electrochemically exfoliated graphene with ruthenium oxide (EG@RuOx) as the positive electrode. This asymmetric device operates at a voltage window of 1.35 V, which is about two times wider than that of a symmetric Mo1.33C@L‐DEA based supercapacitor. Finally, the ASCs can deliver an energy density of 51.9 Wh kg−1 at a power density of 338.5 W kg−1, with 86 % capacitance retention after 10000 charge‐discharge cycles.
Chemical Production from Methanol Using Natural and Synthetic Methylotrophs
Authors: Chen Arvin Y. , Lan Ethan I. 
Published: April 2020

AbstractMethanol as a chemical feedstock is becoming increasingly important as it is derived from natural gas and is a feasible end‐product for captured carbon dioxide. Biological conversion of methanol through natural and synthetic methylotrophs increases the chemical repertoire and is an important direction for one carbon (C1) based chemical economy. Advances in the metabolic engineering and synthetic biology enable development of microbial cell factories for converting methanol into various platform chemicals. In this review, the current status of methanol utilizing microbial factory development is summarized. Also the development of synthetic methylotrophy and methanol‐augmented bioproductions is discussed.
Can we improve the detection rate of prostate cancer using standard 12‐core TRUS‐guided prostate biopsy? Focused on the location of prostate biopsy
Authors: Yoo Sangjun , Suh Jungyo , Park Juhyun , Cho Min Chul , Son Hwancheol , Jeong Hyeon 
Published: April 2020

AbstractBackgroundWe assessed the effect of biopsy location on the prostate cancer detection and clinically significant prostate cancer.MethodsA total of 2774 patients with 12‐core prostate transrectal ultrasound‐guided prostate biopsy were included for per core analysis. Multivariate Cox regression analysis was performed to evaluate the effect of the location of biopsy on the prostate cancer and clinically significant prostate cancer detection.ResultsProstate cancer was found in 775 patients (27.9%) and 576 prostate cancer patients (20.8%) were found to be clinically significant. The core length (P = .043), tumor length (P < .001), and % tumor length (P < .001) were significantly different according to the biopsy location. The detection rates for prostate cancer and clinically significant prostate cancer differed significantly according to the location of biopsy. Multivariate analysis revealed that the apical core was significantly related with increased detection of prostate cancer and clinically significant prostate cancer. The lateral core, in addition to apical core, was found to be significantly related with increased detection rates of prostate cancer and clinically significant prostate cancer in men with prostate‐specific antigen <10 ng/mL.ConclusionsMore in‐depth discussions on the location of standard 12‐core prostate biopsy are considered necessary. Apical core and lateral core biopsies may be helpful, especially in patients with prostate‐specific antigen ˂10 ng/mL if additional biopsies are planned following findings of no target lesions on imaging studies.