bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a Web App for Cognitive Training (MeMo) Regarding Cognitive and Behavioral Performance in People With Neurocognitive Disorders: Randomized Controlled Trial
Authors: Robert Philippe , Manera Valeria , Derreumaux Alexandre , Ferrandez Y Montesino Marion , Leone Elsa , Fabre Roxane , Bourgeois Jeremy 
Published: February 2020

Background
Cognitive and behavioral symptoms are the clinical hallmarks of neurocognitive disorders. Cognitive training may be offered to reduce the risks of cognitive decline and dementia and to reduce behavioral symptoms, such as apathy. Information and communication technology approaches, including serious games, can be useful in improving the playful aspect of computerized cognitive training and providing motivating solutions in elderly patients.

Objective
The objective of this study was to assess the effectiveness of employing the MeMo (Memory Motivation) Web app with regard to cognitive and behavioral symptoms in patients with neurocognitive disorders.

Methods
MeMo is a Web app that can be used on any Web browser (computer or tablet). The training activities proposed in MeMo are divided into the following two parts: memory and mental flexibility/attention. The study included 46 individuals (mean age 79.4 years) with a diagnosis of neurocognitive disorders at the Institut Claude Pompidou Memory Center in Nice. This randomized controlled study compared the evolution of cognition and behavior between patients not using MeMo (control group) and patients using MeMo (MeMo group) for 12 weeks (four sessions per week). Patients underwent memory and attention tests, as well as an apathy assessment at baseline, week 12 (end of the training period), and week 24 (12 weeks after the end of the training sessions). In addition, to assess the impact of high and low game uses, the MeMo group was divided into patients who used MeMo according to the instructions (about once every 2 days; active MeMo group) and those who used it less (nonactive MeMo group).

Results
When comparing cognitive and behavioral scores among baseline, week 12, and week 24, mixed model analysis for each cognitive and behavioral score indicated no significant interaction between testing time and group. On comparing the active MeMo group (n=9) and nonactive MeMo group (n=13), there were significant differences in two attention tests (Trial Making Test A [P=.045] and correct Digit Symbol Substitution Test items [P=.045]) and in the Apathy Inventory (AI) (P=.02). Mixed analysis (time: baseline, week 12, and week 24 × number of active days) indicated only one significant interaction for the AI score (P=.01), with a significant increase in apathy in the nonactive MeMo group.

Conclusions
This study indicates that the cognitive and behavioral efficacies of MeMo, a Web-based training app, can be observed only with regular use of the app. Improvements were observed in attention and motivation.

Trial Registration
ClinicalTrials.gov NCT04142801; https://clinicaltrials.gov/ct2/show/NCT04142801
FORMULATION AND EVALUATION OF ANTIMICROBIAL OINTMENTS FROM EUPATORIUM GLANDULOSUM HORT. EX KUNTH
Authors: SILPA M  , SURESH JOGHEE  , HAMSALAKSHMI  
Published: February 2020

Objective: The present study was undertaken to evaluate the antimicrobial activity of an ointment prepared from alcohol, ethyl acetate, and chloroform extracts of Eupatorium glandulosum Hort. ex Kunth.
Methods: The dried plant materials of E. glandulosum were individually extracted using alcohol, ethyl acetate, and chloroform by Soxhlet method. These three different types of extracts were used for the preparation of ointment and evaluated for the phytochemicals, pH, homogeneity, spreadability, tube extrudability, stability, and antimicrobial activity. The activity of prepared ointments was evaluated against Escherichia coli and Bacillus subtilis and the in vitro antimicrobial activity of ointments of plant extracts was performed by cup plate methods. The most effective antimicrobial ointment was determined by comparing the results of the zone of inhibition of all the ointments of each solvent extract.
Results: The antimicrobial activity of optimized formulation was showed significant activity against the tested bacterial pathogens.
Conclusion: The present study confirmed the antimicrobial activity of the formulations. Furthermore, it can use as a potential dosage form for clinical utility. The results are the justification for the use of the plant in folk medicine.
STUDY OF DIRECT COMPRESSION METHOD FOR THE PREPARATION OF QUINAPRIL HYDROCHLORIDE TABLETS
Authors: SHWETHA MARGRET JL  , MADHAVI BLR  
Published: February 2020

Objective: Direct compression method is preferable for tablet manufacture. The direct compression method is followed for many formulations but the relevant study is not reported. The present work aims to study the suitability of the direct compression process to prepare tablets of quinapril hydrochloride (QHCl), a low dose drug with a starting dose of 5 mg, indicated in the treatment of hypertension, congestive heart failure, and other conditions.
Methods: QHCl is reported to be unstable in the presence of moisture, heat, and some excipients. The direct compression method was tried instead of a wet granulation technique to prepare the tablets. Initially, drug-excipient compatibility study was carried out. For selected excipients and QHCl preformulation tests were conducted. The stabilizer was employed. Three formulations were tried. The blends were prepared by tumbling and trituration methods. Blend uniformity and precompression parameters were determined. Tablets were directly compressed and evaluated.
Results: Drug-excipient compatibility was studied at 60°C and 40°C with an Relative humidity (RH) of 75% for 4 weeks. It showed discoloration of the pure drug and most of the drug excipient mixtures. Three formulations Q1, Q2, and Q3 were prepared using magnesium oxide (light), magnesium carbonate (light), and Aerosil as stabilizers. Blending was done by trituration and tumbling method for 10 min and 15 min duration for the given batch size. Blend uniformity was determined. Tumbling method for 15 min showed good blending as evident from the percentage coefficient of variation values. The blends had a good flow. Tablet evaluation showed hardness in the range of 2.5–3 kg/cm2 and disintegration time of 1–2 min. Q1 and Q2 passed the friability test. The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics. The stability study of Q1 indicated a single peak in the chromatogram corresponding to the drug. Q2 showed spotted discoloration.
Conclusion: The direct compression technique could be employed for the preparation of QHCl tablets. Q1 showed better stability and release characteristics. Q2 and Q3 are considered for further study.
EFFECT OF SLEEP DEPRIVATION ON REMINISCENCE AND APPREHENSION BEHAVIOR IN WISTAR ALBINO RATS
Authors: PRIYA CS KEERTHI , S MALATHI , RAJAN RAVINDRAN 
Published: February 2020

Objective: The aim of the present study is to investigate the effect of paradoxical sleep deprivation (SD) on learning and memory impairment and anxiety-like behavior in female Wistar albino rats.
Methods: Eight-arm radial maze, open-field test, and light and dark test were used to assess the animals learning and memory and anxiety-like behavior.
Results: SD associated with weaker learning and memory and increased anxiety- and depressive-like behavior in animals.
Conclusion: Animals were exposed to SD showed learning and memory impairment and also exhibited increased anxiety- and depressive-like behavior when compared to control animals.
AMELIORATION OF ACETAMINOPHEN-INDUCED HEPATOTOXICITY USING SOLANUM TORVUM SW. FRUIT EXTRACT IN WISTAR RATS
Authors: UMERA BEGAM AK  , SENTHILKUMAR R  , SIRAJUDEEN J  
Published: February 2020

Objective: Ayurveda and Chinese pharmacopeia have highlighted the traditional medicinal uses of Solanum torvum Sw. The fruits are ethnomedical used in the treatment of liver and spleen enlargement, cough, and also used as a hematopoietic, antimicrobial, and analgesic agent. In the present study, the amelioration of acetaminophen (APAP)-induced hepatotoxicity of the aqueous extract of S. torvum Sw. fruits is evaluated.
Methods: The hepatoprotective activity of the fruit extract against APAP insult was evaluated by assessing it is in vivo antioxidants status, membrane-bound adenosine triphosphatases (ATPases), and tricarboxylic acid (TCA) cycle marker enzymes and also through histopathological studies of the liver.
Results: Administration of the aqueous fruit extract of the plant caused a significant increase in the in vivo antioxidant status as evident from the reduction in lipid peroxidation caused by APAP and improvement in the mitochondrial membrane stability which is proved from the activity of membrane-bound ATPases and TCA cycle marker enzymes. Histological studies also supported the fact that the plant extract proved to revive the architecture of the toxin damaged liver tissues in par with silymarin. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the aqueous extract of S. torvum.
Conclusion: The results showed that the extract of S. torvum Sw. fruits has hepatoprotective potential which may be due to the antioxidant activity of its phytoconstituents, especially flavonoids, alkaloids, phenolics, etc.
SIMPLE BIOANALYTICAL QUANTIFICATION METHOD FOR SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND EZETIMIBE IN HUMAN PLASMA BY REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE
Authors: DYADE GK  , SAWANT RL  
Published: February 2020

Objective: A bioanalytical quantification method was developed for the simultaneous estimation of simvastatin (SIM) and ezetimibe (EZE) from the human plasma.
Methods: The technique was developed and equipped with reverse-phase (RP) high-performance liquid chromatography, using RP-C18 column with an ultraviolet detector. For the estimation of SIM and EZE, the mobile phase (acetonitrile:acetate buffer pH 4.0, pH adjusted with acetic acid) was pumped at a flow rate of 0.8 ml/min in the ratio of 85:15% v/v and the eluents were monitored at 234 nm. A calibration graph to study linearity of the SIM and EZE in biological matrix was carried out in the concentration range of 400–4000 ng/ml for both these drugs SIM and EZE.
Results: The developed method was validated according to the US FDA and European Medicines Agency guidelines for sensitivity, accuracy, precision, and stability. The obtained statistical data of validation were found to be within prescribed limit assures rigidity of the method. Both the drugs in combined form were estimated in human plasma by the proposed method.
Conclusions: The developed method is free from solid-phase extraction so it becomes simple and economical. The method is efficient for precise and accurate quantification of SIM and EZE in plasma and hence applied for bioequivalence, bioavailability study in real clinical samples.
THE INFLUENCE OF PARTICIPATIVE COUNSELING APPROACH ON IMPROVING BREASTFEEDING SELF-EFFICACY TO PREGNANT WOMEN IN INDONESIA
Authors: FAUZIA FAUZIA  , NI WAYAN DIAN EKAYANTHI  , AHMAD FUDHOLI  
Published: February 2020

Objective: The objective of this study was to know the effect of participatory counseling on increasing breastfeeding self-efficacy (BSE) in pregnant women in Bogor city, Indonesia.
Methods: The pre-experimental design method, namely, one group pretest-posttest, with the number of study subjects was 35 third trimester pregnant women with normal reproductive age without complications in the Bogor City. Data analysis was performed by univariable and bivariable by Friedman test and Wilcoxon post hoc test and multivariable using linear regression test.
Results: Participatory counseling has an effect on increasing breastfeeding efficacy in pregnant women (p<0.001), while confounding variables (education, parity, own breastfeeding experience, and other’s experience of breastfeeding) have no significant effect on increasing BSE in pregnant women (p>0.05).
Conclusion: Participatory counseling increases BSE in pregnant women.
IVABRADINE HYDROCHLORIDE DIRECTLY COMPRESSED TABLETS USING NANO-CELLULOSE EXTRACTED FROM ARACHIS HYPOGAEA SHELLS
Authors: JEEVANA JYOTHI B  , APARNA J  
Published: February 2020

Objective: The main objective of this work was the extraction of nanocellulose from Arachis hypogaea shells, characterization of nanocellulose, development, and in vitro evaluation of directly compressed tablets of ivabradine hydrochloride (IVH) using nanocellulose.
Methods: IVH and colloidal silicon dioxide are gift samples from Mylan Laboratory, Hyderabad, and Karnataka Antibiotics and Pharmaceuticals Ltd., Bengaluru, respectively. Nanocellulose was extracted from A. hypogaea shells by alkaline treatment followed by acid hydrolysis and it was characterized by particle size analysis by zeta sizer, melting point determination, differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) analysis. Compatibility between IVH and nanocellulose was confirmed by FTIR and DSC analysis. Then, fast-release tablets of containing 5 mg of IVH were prepared by direct compression using various compositions containing nanocellulose, starch, and colloidal silicon dioxide and evaluated.
Results: Nanocellulose in the size of 273.4 nm was extracted from A. hypogaea shells to possess its ideal characteristics. IVH and nanocellulose were compatible according to FTIR and DSC analysis. Fast-release tablets of IVH were prepared as directly compressed tablets by direct compression. Tablets made with 5 mg of IVH and nanocellulose, starch, and colloidal silicon dioxide evidenced fast release of 96.37% in 5 min.
Conclusion: Nanocellulose from A. hypogaea shells can be produced successfully by alkali treatment followed by acid hydrolysis, ball milling, and lyophilization. This nanocellulose can be exploited successfully for the design of fast-release tablets of IVH.
EVALUATION OF INNOVATED FORMULA OF BISACODYL SUPPOSITORY FOLLOWING THE DISSOLUTION PROFILE AND STABILITY DATA USING DEVELOPED HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD
Authors: J HASSON KAHTAN , G JABAR ESRAA , I ALKHALIFA IHAB 
Published: February 2020

Objective: Bisacodyl is a laxative drug used in the treatment of constipation, it is soluble in mineral acids, but it is practically insoluble in water. Therefore, it is very hard task to dissolve bisacodyl in alkaline medium so the objective of this study was the development of proper dissolution method for a new formulation of bisacodyl suppositories in a medium simulated to rectal region. Obviously, most of the bisacodyl suppositories preparation products will yield low percentages of dissolution in the alkaline medium of phosphate buffer pH 7.2.
Methods: Preparation inclusion complex of bisacodyl with the solubilizing agent beta-cyclodextrin then incorporated in a suppository base. The quantitative analysis of bisacodyl in suppositories was carried by a developed and validated high-performance liquid chromatography method.
Results and Discussion: The dissolution rates for the innovated formulation of bisacodyl complexed with beta-cyclodextrin suppositories were in average of 97.5% and the stored suppositories of this formulation maintained their specified physical and chemical properties along the real stability study.
Conclusion: The application of the inclusion complexation technique of bisacodyl with beta-cyclodextrin in the production of suppositories enhances the dissolution rate and improves the stability of suppositories performance.
Abanico de maternidades. Un estado del arte desde los aportes feministas
Authors: Romero Guzmán María Lizet , Tapia Tovar Evangelina , Meza Márquez Consuelo 
Published: February 2020

El artículo contiene un estado del arte de investigaciones prominentes que han abordado las maternidades desde los estudios feministas de la segunda ola y desde los Estudios de género, cuyas autoras, principalmente del hemisferio occidental, tomaron referentes de la historia, la sociología y la antropología. Abre con un enfoque histórico con el fin de contextualizar la maternidad como una construcción cultural multiforme; posteriormente, presenta investigaciones de maternidades diversas, señaladas por salirse de los parámetros de la maternidad tradicional: madres adolescentes, madres lesbianas, madres filicidas, mujeres que no quieren ser madres, madres feministas. El análisis de las contribuciones posibilita vertientes de debates actuales a nivel nacional e internacional. Asimismo, puntea directrices para la continuación y la profundización en estudios sobre las llamadas “nuevas maternidades”. Abanico
A Cluster-First Route-Second Heuristic Approach to Solve The Multi-Trip Periodic Vehicle Routing Problem
Authors: Garside Annisa Kesy , Laili Nabila Rohmatul 
Published: February 2020

This paper discusses periodic vehicle routing problems that allow vehicles to travel on multiple trips in a single day. It is known as the Multi-Trip Periodic Vehicles (MTPVRP) Problem Route. Cluster-first route-second (CFRS) heuristics to solve MTPVRP was proposed in this study. In phase 1, customers were divided into clusters using the formulation of integer programming. Phase 2 determined the route of the cluster and verified that the total journey time to visit the trips does not exceed the working hours of the vehicle. Implementing the heuristic CFRS to solve the real problem faced by the Liquefied petroleum gas (LPG) distributor shows that the procedure could provide a better routing solution.
REMOÇÃO CIRÚRGICA DE CISTO RADICULAR COM TRATAMENTO ENDODÔNTICO RETRÓGRADO: 2 ANOS DE ACOMPANHAMENTO
Authors: Almeida Costa Yasmin Jeane 
Published: February 2020

RESUMO O cisto inflamatório radicular é uma cavidade patológica verdadeiramente revestida por epitélio geralmente originária de um dente desvitalizado com necrose pulpar. Sua exérese, quando devidamente indicada, é necessária devido a possibilidade de alcançar grandes proporções provocando a destruição do tecido ósseo circundante, além de ser foco para o desenvolvimento de processos infecciosos. A técnica de enucleação cística com tratamento endodôntico retrógrado, permite que a lesão seja removida preservando-se os elementos dentários envolvidos. Este trabalho tem como objetivo relatar e discutir o caso clínico realizado nas clínicas de Cirurgia Oral Menor e Endodontia da Faculdade de Odontologia da Universidade Federal Fluminense (UFF). O exame histopatológico, realizado no Laboratório Associado de Pesquisa Clínica em Odontologia da UFF comprovou a suspeita diagnóstica inicial de cisto radicular. Concluímos que o tratamento do cisto radicular inflamatório é bastante previsível quando precedido de uma minuciosa abordagem clínica pré-operatória. A conduta terapêutica adotada para este caso foi correta e conduziu o paciente à cura, recebendo alta definitiva após dois anos de acompanhamento.Palavras-chave: Cirurgia Paraendodôntica. Cisto Radicular. Apicectomia. Cistos Odontogênicos. Enucleação Cística. Obturação Simultânea. ABSTRACT The radicular inflammatory cyst is a pathological cavity truly lined with epithelium, usually originating from a devitalized tooth with pulp necrosis. Its excision, when properly indicated, is necessary due to the possibility of reaching large proportions destroying the surrounding bone tissue, besides being a focus for the development of infectious processes. The cystic enucleation technique with retrograde endodontic treatment allows the lesion to be removed while preserving the involved dental elements. This paper aims to report and to discuss the case report conducted at the Clinics of Minor Oral Surgery and Endodontics, Faculty of Dentistry, Fluminense Federal University (UFF). The histopathological examination, performed at the Associated Laboratory of Clinical Research in Dentistry of UFF, confirmed the initial diagnostic suspicion of root cyst. We conclude that the treatment of the inflammatory root cyst is quite predictable when preceded by a thorough preoperative clinical approach. The therapeutic approach adopted for this case was correct and led the patient to cure and was discharged after two years of follow-up.Keywords: Paraendodontic Surgery. Radicular Cyst. Apicoectomy. Odontogenic Cyst. Cystic Enucleation. Simultaneous Filling.
Governança Colaborativa em Instituições de Ensino: Uma Quasi- Revisão Sistemática da Literatura
Authors: Ferreira Neves Danilo , Cerqueira Santos Lidiany , Alves Santos Mylena , Colaço Rodrigues Júnior Methanias 
Published: February 2020

Contexto. Tecnologias para estimular a participação eletrônica vem sendo adotadas por governos como forma de legitimar direitos, promover transparência e resolver problemas de forma mais eficiente. Embora validada no cenário político, a governança colaborativa ainda é pouco adotada em centros acadêmicos. Objetivo. Entender e mapear como práticas colaborativas estão sendo adotadas na governança de instituições de ensino. Metodologia. Foi elaborada uma Quasi-revisão sistemática da literatura. Resultado. A busca selecionou 3 estudos entre 526. Após análise, foram identificados nos estudos os recursos pertinentes para viabilização de colaboração, as práticas de participação utilizadas e como a inserção desse modelo administrativo influenciou na qualidade de ensino e no desenvolvimento da comunidade acadêmica. Conclusão. Pelo caráter metodológico aplicado, o trabalho serve como um guia, identificando tendências e sintetizando práticas que podem ser replicadas em novos projetos.
Identificação dos fatores de melhorias no IDEB pelo uso de mineração de dados: Um estudo de caso em escolas municipais de Teotônio Vilela-Alagoas
Authors: Da Silva Pinto Glevson , De Gusmão Freitas Júnior Olival , De Barros Costa Evandro 
Published: February 2020

A Mineração de Dados Educacionais vem auxiliando educadores e gestores no apoio a tomada de decisões, permitindo extração de informações relevantes de bases de dados. O objetivo deste artigo é identificar os fatores que afetam o desempenho escolar dos alunos (IDEB) das escolas de ensino fundamental do município de Teotônio Vilela através dos resultados obtidos na Prova Brasil. Neste artigo explorou-se técnicas de seleção de atributos e mineração de dados, identificando quais fatores impactam no IDEB das escolas municipais de Alagoas para posteriores estudos e reflexões na área da educação. Para tanto, utilizou-se dados do SAEB das escolas públicas municipais de Teotônio Vilela, conduzindo um estudo experimental, produzindo relevantes resultados na tarefa de identificação de atributos relevantes para apoiar os gestores educacionais.
LocalLearn: Um modelo U-Learning para auxílio no aprendizado do vocabulário de Inglês
Authors: Garcia da Silva Letícia , Francisco Rosemary , Barbosa Jorge 
Published: February 2020

Aprendizes de idiomas geralmente enfrentam problemas de comunicação aodesejarem falar algo e não saberem a palavra ideal. Além disso, os contínuos avanços da tecnologia estão criando novas oportunidades para a aquisição de vocabulário de uma segunda língua por meio da tecnologia. Este artigo apresenta um modelo de aprendizado ubíquo para auxiliar os estudantes de inglês a aprender novos vocabulários. O estudo avaliou a viabilidade de apoiar o aprendizado de inglês no contexto do usuário. Os resultados indicam uma resposta favorável ao uso do contexto para auxiliar o usuário em sua aprendizagem. Foi alcançada uma aceitação de 78,66% para a percepção de utilidade e 96% para a percepção de facilidade de uso.