bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
Authors: Papadimitriou Nikos , Muller David , van den Brandt Piet A. , Geybels Milan , Patel Chirag J. , Gunter Marc J. , Lopez David S. , Key Timothy J. , Perez-Cornago Aurora , Ferrari Pietro , Vineis Paolo , Weiderpass Elisabete , Boeing Heiner , Agudo Antonio , Sánchez María-José , Overvad Kim , Kühn Tilman , Fortner Renee T. , Palli Domenico , Drake Isabel , Bjartell Anders , Santiuste Carmen , Bueno-de-Mesquita Bas H. , Krogh Vittorio , Tjønneland Anne , Lauritzen Dorthe Furstrand , Gurrea Aurelio Barricarte , Quirós José Ramón , Stattin Pär , Trichopoulou Antonia , Martimianaki Georgia , Karakatsani Anna , Thysell Elin , Johansson Ingegerd , Ricceri Fulvio , Tumino Rosario , Larrañaga Nerea , Khaw Kay Tee , Riboli Elio , Tzoulaki Ioanna , Tsilidis Konstantinos K. 
Published: November 2019

AbstractPurposeThe evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive.MethodsA nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS).ResultsA total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-correctedP, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS.ConclusionsOur findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.
Cognitive and affective Theory of Mind in adolescence: developmental aspects and associated neuropsychological variables
Authors: Gabriel Edith Theresa , Oberger Raphaela , Schmoeger Michaela , Deckert Matthias , Vockh Stefanie , Auff Eduard , Willinger Ulrike 
Published: November 2019

Abstract
Theory of Mind (ToM) is the ability to represent and attribute mental states to oneself and others. So far, research regarding ToM processing across adolescence is scarce. Existing studies either yield inconsistent results or did not or not thoroughly investigate aspects like higher order ToM and associated neuropsychological variables which the current study tried to address. 643 typically developing early, middle, and late adolescents (age groups 13–14; 15–16; 17–18) performed cognitive and affective ToM tasks as well as neuropsychological tasks tapping the cognitive or affective domain. Regarding both ToM types, 15- to 16-year-olds and 17- to 18-year-olds outperformed 13- to 14-year-olds, whereas females were superior regarding cognitive ToM. Across adolescence, cognitive and affective ToM correlated with attention and affective intelligence, whereas working memory, language comprehension, and figural intelligence additionally correlated with cognitive ToM. In early adolescence, attention correlated with both ToM types, whereas cognitive ToM further correlated with language comprehension and affective ToM with verbal intelligence, verbal fluency, and verbal flexibility. In middle and late adolescence, affective intelligence correlated with both ToM types, whereas cognitive ToM additionally correlated with working memory, language comprehension, and figural intelligence. The current study shows a developmental step regarding cognitive and affective ToM in middle adolescence as well as gender differences in cognitive ToM processing. Associations between neuropsychological variables and ToM processing were shown across adolescence and within age groups. Results give new insights into social cognition in adolescence and are well supported by neuroscientific and neurobiological studies regarding ToM and the integration of cognitive and affective processes.

Graphic abstract
Bestimmung und Abtrennung des Fremdstoffgehaltes von Bioabfällen mittels Siebung und Windsichtung
Authors: Ferreux Julie , do Carmo Precci Lopes Alice , Müller Wolfgang , Robra Sabine , Bockreis Anke 
Published: November 2019

ZusammenfassungKunststofffolien im Bioabfall führen zu Herausforderungen für Bioabfallbehandlungsanlagen, da sie trotz Aufbereitung in den fertigen Kompost gelangen. Anlässlich der neuen Grenzwerte des RAL-Gütezeichens wurde die Anwendung eines Stern- und Trommelsiebs sowie eines Querstrom-Windsichters in der Voraufbereitung von zwei Bioabfallbehandlungsanlagen in Deutschland untersucht.Untersucht wurde die Effizienz der Kunststofffolienabtrennung und die Transferraten der Biogaserträge in die entstehenden Fraktionen. Dafür wurden Proben aus großtechnischen Versuchen gezogen, händisch sortiert und alle Fremdstoffe gewaschen und getrocknet. Anschließend wurde das Biogaspotenzial mit einem automatisierten Batch-Gärtest gemessen.Die Ergebnisse weisen einen Verlust von ca. 30 % an Biogas aus, der durch die Abtrennung der anhaftenden organischen Substanz während der Aufbereitung bedingt ist. Dem gegenüber steht eine Abtrennung von ca. 90 % der Kunststofffolien, was ein Erreichen der Grenzwerte des RAL-Gütezeichens potenziell ermöglicht.
Coding-complete genome sequencing suggests that Newcastle disease virus challenge strain Herts’33 (IVMP) may represent a distinct genotype
Authors: Fehér Enikő , Bálint Ádám , Marton Szilvia , Bali Krisztina , Belák Sándor , Bányai Krisztián 
Published: November 2019

Abstract
We determined the genomic sequence of a Newcastle disease virus (NDV) line obtained directly from the first NDV isolate, named Herts’33. This strain shared ≤ 90% nucleotide sequence identity with the NDV sequences available in the GenBank database, and formed a distinct branch in a phylogenetic tree. This branch may be considered to represent a separate NDV genotype. Our study indicates that investigation of the genomic sequences of old NDV strains that originated from the early outbreaks of Newcastle disease may alter the phylogenetic grouping of the NDV strains and provide data on the evolution of viral genomes over time.
Toddlers’ diurnal cortisol levels affected by out-of-home, center-based childcare and at-home, guardian-supervised childcare: comparison between different caregiving contexts
Authors: Tervahartiala Katja , Karlsson Linnea , Pelto Juho , Kortesluoma Susanna , Hyttinen Sirpa , Ahtola Annarilla , Junttila Niina , Karlsson Hasse 
Published: November 2019

Abstract
Previous research suggests that attending non-parental out-of-home childcare is associated with elevated cortisol levels for some children. We aimed to compare diurnal saliva cortisol levels between children having out-of-home, center-based childcare or those having at-home, guardian-supervised childcare in Finland. A total of 213 children, aged 2.1 years (SD = 0.6), were drawn from the ongoing Finnish birth cohort study. Saliva samples were collected over 2 consecutive days (Sunday and Monday), with four samples drawn during each day: 30 min after waking up in the morning, at 10 am, between 2 and 3 pm, and in the evening before sleep. These results suggest that the shapes of the diurnal cortisol profiles were similar in both childcare groups following a typical circadian rhythm. However, the overall cortisol levels were on average 30% higher (95% CI: [9%, 54%], p = .004) with the at-home childcare in comparison with the out-of-home childcare group. Furthermore, a slight increase in the diurnal cortisol pattern was noticed in both groups and in both measurement days during the afternoon. This increase was 27% higher ([2%, 57%], p = .031) in the out-of-home childcare group during the out-of-home childcare day in comparison with the at-home childcare day. The elevated afternoon cortisol levels were partly explained by the afternoon naps, but there were probably other factors as well producing the cortisol rise during the afternoon hours. Further research is needed to define how a child’s individual characteristic as well as their environmental factors associate with cortisol secretion patterns in different caregiving contexts.
Construction of a new integrating vector from actinophage ϕOZJ and its use in multiplex Streptomyces transformation
Authors: Ko Bryan , D’Alessandro John , Douangkeomany Lee , Stumpf Spencer , deButts Ashby , Blodgett Joshua 
Published: November 2019

Abstract
Streptomyces and other closely-related actinobacteria are important sources of bioactive molecules. Streptomyces synthetic biology and genetics empower therapeutic and agrichemical development through strain improvement and biosynthetic understanding. Such efforts rely on the availability of developed molecular toolsets. Among these tools, vectors that enable combinatorial chromosomal manipulations are particularly desirable. Towards developing tools for facile multiplex engineering, we herein describe the development of new integrating vectors derived from BD1 subgroup actinophage OzzyJ (ϕOZJ). By demonstrating the transformation of several Streptomyces spp. using ϕOZJ-derived vectors, we reveal their potential for strain engineering. We further report the development of new ϕC31 and ϕBT1-based vectors having orthogonal resistance, replication and integration features for concomitant transformation with our ϕOZJ-derived vectors. Importantly, the resulting compatible vector panel enabled us to demonstrate the transfer of up to three plasmids each into Streptomyces venezuelae, Streptomyces roseosporus and Streptomyces pristinaespiralis during a single conjugation experiment. To our knowledge this is the first documentation of conjugation-mediated multiplex plasmid transformation, a useful approach for rapid combinatorial strain development.
A new bi-objective model of the urban public transportation hub network design under uncertainty
Authors: Kaveh Firoozeh , Tavakkoli-Moghaddam Reza , Triki Chefi , Rahimi Yaser , Jamili Amin 
Published: November 2019

AbstractThis paper presents a new bi-objective multi-modal hub location problem with multiple assignment and capacity considerations for the design of an urban public transportation network under uncertainty. Because of the high construction costs of hub links in an urban public transportation network, it is not economic to create a complete hub network. Moreover, the demand is assumed to be dependent on the utility proposed by each hub. Thus, the elasticity of the demand is considered in this paper. The presented model also has the ability to compute the number of each type of transportation vehicles between every two hubs. The objectives of this model are to maximize the benefits of transportation by establishing hub facilities and to minimize the total transportation time. Since exact values of some parameters are not known in advance, a fuzzy multi-objective programming based approach is proposed to optimally solve small-sized problems. For medium and large-sized problems, a meta-heuristic algorithm, namely multi-objective particle swarm optimization is applied and its performance is compared with results from the non-dominated sorting genetic algorithm. Our experimental results demonstrated the validity of our developed model and approaches. Moreover, an intensive sensitivity analyze study is carried out on a real-case application related to the monorail project of the holy city of Qom.
Electrochemical recovery of tellurium from metallurgical industrial waste
Authors: Halli Petteri , Wilson Benjamin P. , Hailemariam Taye , Latostenmaa Petri , Yliniemi Kirsi , Lundström Mari 
Published: November 2019

Abstract
The current study outlines the electrochemical recovery of tellurium from a metallurgical plant waste fraction, namely Doré slag. In the precious metals plant, tellurium is enriched to the TROF (Tilting, Rotating Oxy Fuel) furnace slag and is therefore considered to be a lost resource—although the slag itself still contains a recoverable amount of tellurium. To recover Te, the slag is first leached in aqua regia, to produce multimetal pregnant leach solution (PLS) with 421 ppm of Te and dominating dissolved elements Na, Ba, Bi, Cu, As, B, Fe and Pb (in the range of 1.4–6.4 g dm−3), as well as trace elements at the ppb to ppm scale. The exposure of slag to chloride-rich solution enables the formation of cuprous chloride complex and consequently, a decrease in the reduction potential of elemental copper. This allows improved selectivity in electrochemical recovery of Te. The results suggest that electrowinning (EW) is a preferred Te recovery method at concentrations above 300 ppm, whereas at lower concentrations EDRR is favoured. The purity of recovered tellurium is investigated with SEM–EDS (scanning electron microscope–energy dispersion spectroscopy). Based on the study, a new, combined two-stage electrochemical recovery process of tellurium from Doré slag PLS is proposed: EW followed by EDRR.

Graphic abstract
Patterns of Homotypic and Heterotypic Continuity Between ADHD Symptoms, Externalising and Internalising Problems from Age 7 to 15
Authors: Obsuth Ingrid , Murray Aja Louise , Di Folco Simona , Ribeaud Denis , Eisner Manuel 
Published: November 2019

Abstract
ADHD presents a serious community-health problem through its links to a wide range of negative outcomes. These outcomes are exacerbated when ADHD symptoms co-occur with other mental health problems. Research evidence suggests high rates of co-comorbidity with a range of problems. However, there is a paucity of longitudinal research that examines the predictive links between ADHD symptoms and symptoms of other mental health problems. We examined a cross-lagged autoregressive model in order to assess homotypic and heterotypic continuity between ADHD symptoms, aggressive behavior, non-aggressive behavior problems and anxiety/depression in a community-based sample of 1571 youth (761 female, 810 male) assessed annually from age 7 to 13 and again at age 15. Consistently significant correlations between each pair of problem behaviors provided support for concurrent comorbidity. Furthermore, significant autoregressive pathways provided support for homotypic continuity. Support for heterotypic continuity was limited to ADHD symptoms predicting both aggressive behavior and non-aggressive behavior problems, but not vice versa. Our study highlights the importance of focusing on ADHD symptoms to identify children at risk not only for continued ADHD symptomatology but also a range of externalizing behavior problems including different types of aggression and non-aggressive behavior problems, such as rule-breaking. Identifying these patterns in a community-based sample provides support for the possibility of early identification of risk for a range of problem behaviors.
Understanding Number Line Estimation in Williams Syndrome and Down Syndrome
Authors: Simms V. , Karmiloff-Smith A. , Ranzato E. , Van Herwegen J. 
Published: November 2019

AbstractPrevious studies suggest that tasks dependent on the mental number line may be difficult for Williams Syndrome (WS) and Down Syndrome (DS) groups. However, few have directly assessed number line estimation in these groups. The current study assessed 28 WS, 25 DS and 25 typically developing (TD) participants in non-verbal intelligence, number familiarity, visuo-spatial skills and number line estimation. Group comparisons indicated no differences in number line estimation. However, the WS group displayed difficulties with visuo-spatial skills and the DS group displayed difficulties with number familiarity. Differential relationships between number line estimation and visuo-spatial/number familiarity skills were observed across groups. Data is discussed in the context of assessment of skills in neurodevelopmental disorders.
Continuous respiratory rate monitoring during an acute hypoxic challenge using a depth sensing camera
Authors: Addison Paul S. , Smit Philip , Jacquel Dominique , Borg Ulf R. 
Published: November 2019

Abstract
Respiratory rate is a well-known to be a clinically important parameter with numerous clinical uses including the assessment of disease state and the prediction of deterioration. It is frequently monitored using simple spot checks where reporting is intermittent and often prone to error. We report here on an algorithm to determine respiratory rate continuously and robustly using a non-contact method based on depth sensing camera technology. The respiratory rate of 14 healthy volunteers was studied during an acute hypoxic challenge where blood oxygen saturation was reduced in steps to a target 70% oxygen saturation and which elicited a wide range of respiratory rates. Depth sensing data streams were acquired and processed to generate a respiratory rate (RRdepth). This was compared to a reference respiratory rate determined from a capnograph (RRcap). The bias and root mean squared difference (RMSD) accuracy between RRdepth and the reference RRcap was found to be 0.04 bpm and 0.66 bpm respectively. The least squares fit regression equation was determined to be: RRdepth = 0.99 × RRcap + 0.13 and the resulting Pearson correlation coefficient, R, was 0.99 (p < 0.001). These results were achieved with a 100% reporting uptime. In conclusion, excellent agreement was found between RRdepth and RRcap. Further work should include a larger cohort combined with a protocol to further test algorithmic performance in the face of motion and interference typical of that experienced in the clinical setting.
Working for an entrepreneur: heaven or hell?
Authors: Nyström Kristina 
Published: November 2019

AbstractRecruiting employees to an entrepreneurial venture is a challenging task. From the employee’s perspective, accepting a position in an entrepreneurial venture potentially implies considerable uncertainty. This paper provide a literature review and identifies research gaps related to labor mobility of employees into and out of entrepreneurial firms. Who works for an entrepreneur? What are the conditions under which the employees of entrepreneurial firms work? Additionally, labor mobility after an employee works for an entrepreneurial firm is discussed. In conclusion, the quality of the jobs generated by entrepreneurial firms may be questionable (and still relatively unexplored in empirical research), but they are nevertheless important from a labor dynamic perspective. Better understanding about motives to work for an entrepreneur, issues related to job security beyond survival rates, and job quality may contribute to ease the recruitment problems that many entrepreneurial firms struggle with. Furthermore, the relevance and potential pros and cons of working for an entrepreneurial firm in future career paths (entrepreneur or employee) need to be carefully addressed in future research.
The Public Power of Judgement: Reasonableness Versus Rationality—Setting the Ball Rolling
Authors: Cern Karolina M. , Aroso Linhares José Manuel , Wojciechowski Bartosz 
Published: November 2019

Abstract
The chief concern of the paper is to initiate discussion on the difference between the private and public power of judgement. The inspiration comes from Kant and his conception of the power of judgement, customs, morality and provisional law.
The Leading Role of Peptide Tyrosine Tyrosine in Glycemic Control After Roux-en-Y Gastric Bypass in Rats
Authors: Camacho-Ramírez Alonso , Prada-Oliveira J. Arturo , Ribelles-García Antonio , Almorza-Gomar David , Pérez-Arana Gonzalo M. 
Published: November 2019

Abstract

Aims
Roux-en-Y gastric bypass (RYGB) is one of the most effective surgical therapies for the rapid resolution of type 2 diabetes. However, the mechanisms underlying the entero-hormonal response after surgery and the role of peptide tyrosine tyrosine (PYY) in the restoration of normoglycemia are still not clear.

Methods
We reproduced the RYGB technique in Wistar and Goto–Kakizaki rats and performed serum hormonal, histological, and hormonal-infusion test.

Results
Using the diabetic Goto–Kakizaki (GK) rat model, we demonstrated that PYY plasma levels showed a remarkable peak approximately 30 min earlier than GLP-1 or GIP after mixed-meal administration in RYGB-operated rats with PYY. The GLP-1 and GIP areas under the curve (AUCs) increased after RYGB in GK rats. Additionally, the findings suggested that PYY (3-36) infusion led to increased GLP-1 and GIP plasma levels close to those obtained after a meal. Finally, the number of GLP-1-positive cells appeared to increase in the three segments of the small intestine in GK-RYGB-operated rats beyond the early presence of nutrient stimulation in the ileum. Nevertheless, PYY-positive cell numbers appeared to increase only in the ileum.

Conclusion
At least in rats, these data demonstrate an earlier essential role for PYY in gut hormone regulation after RYGB. We understand that PYY contributes to GLP-1 and GIP release and there must be the existence of enteroendocrine communication routes between the distal and proximal small intestine.
Presupposing, Believing, Having Faith
Authors: Gómez Rincón Carlos Miguel 
Published: November 2019

AbstractThis paper traces the borders between presupposing, believing, and having faith. These three attitudes are often equated and confused in the contemporary image of the historically and culturally situated character of rationality. This confusion is problematic because, on the one hand, it prevents us from fully appreciating the way in which this image of rationality points towards a dissolving of the opposition between faith and reason; on the other hand, it leads to forms of fideism. After bringing this differentiation into sharper focus, a concept of faith in turn will come into view which challenges contemporary forms of fideism, to the extent that it embraces the possibility of examining and evaluating our systems of beliefs and basic presuppositions. This examination has nothing to do with justification or verification but rather with a sort of confrontation and discernment of the trust we have in what we take for granted.