bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Entrepreneurship and Agile Methods—A Hackathon Case Study
Authors: Richter Nancy , Dragoeva Djanina 
Published: November 2020

Abstract“What if, when they ask ‘Alexa, where can I do something here tonight?’, travellers no longer receive the answer ‘I don’t know’? And, could start-ups use all tourist data freely and without restriction to develop innovative applications for travellers at any time?” (“German National Tourist Board”, n.d.). These and similar questions are currently being asked by those responsible for tourism marketing and product development, such as destination management organisations (DMO: “Public or public–private entity whose aim is to foster, plan and coordinate the tourism development of a destination as a whole”.) (“IGI Global”, n.d.) in Germany. In particular, the travel destination Thuringia sees itself as a pioneer on topics such as AI, decentralised data structures and new types of interactions: “We were looking for a way to make the data of Thuringian tourism up-to-date, findable and freely usable and thus provide the path for open innovation and new technologies.” (Detlef Klinge, Thüringer Tourismus GmbH retrieved from “German National Tourist Board”, n.d.). To meet these challenges, the DMO relies on the processing of open data in a tourist content architecture and on entrepreneurial management methods such as the hackathon. This method, in turn, must be embedded in a holistic management approach; otherwise, creative results will be lost even before they come to the market. The question is how these technologies and management methods must be implemented in DMOs so that they generate sustainable competitive advantages and customer benefits for the respective travel destination.
Lebensentwürfe im Spannungsfeld von Ökonomisierung, Selbstverwirklichung und unternehmerischer Nachhaltigkeit
Authors: Thrun Tim , Casper Marc , Schormair Maximilian 
Published: November 2020

ZusammenfassungIm Zentrum des Beitrags steht das dreiteilige Lehrkonzept des titelgebenden Seminars. In einem ersten Reflexionsblock leisten die Teilnehmerinnen und Teilnehmer überwiegend biographisch orientierte Reflexionen. Die dabei subjektiv formulierten Lebensentwürfe werden im zweiten Block durch Filmvorführungen und -diskussionen kontrastiert. Im Rahmen eines dritten Referatsblocks vertiefen die Teilnehmerinnen und Teilnehmer ihre bisherigen Überlegungen vor dem Hintergrund eines aktuell diskutierten Themas der Wirtschaftswissenschaft. Das Seminar zeichnet sich über diese drei Elemente hinweg durch seinen kritisch-emanzipatorischen Modus und eine ausgeprägte Lebensweltorientierung aus.
Lehre im Interesse der Studierenden: Selbstverständnis, Prinzipien und Praktiken einer bildungswirksamen Hochschullehre
Authors: Haarmann Moritz Peter 
Published: November 2020

ZusammenfassungAusgehend von einer Problematisierung der Fremdbestimmung, gegen die die in der Pluralen Ökonomik engagierten Studierenden und Lehrenden der Volkswirtschaftslehre protestieren, widmet sich der Beitrag der Frage, wie Hochschullehre adressatinnen- und adressatenorientiert gestaltet werden kann. Das hochschuldidaktische Fundament einer Lehre im Interesse der Studierenden wird aus der Bildungstheorie und dem Universitätskonzept Wilhelm von Humboldts entwickelt und anhand von Umsetzungsbeispielen konkretisiert. Weitergehende Prinzipien speziell für die sozioökonomische Hochschullehre werden unter Bezugnahme auf etablierte Grundsätze der allgemeinen Didaktik sowie der Didaktik für sozialwissenschaftliche Unterrichtsfächer formuliert. Ein zentrales Ergebnis dabei ist, dass der politische Charakter von Wirtschaft und den mit ihr befassten Sozialwissenschaften nachvollzogen werden muss, um Studierenden eine bildungswirksame Auseinandersetzung mit Ökonomie und Ökonomik zu ermöglichen.
„Warum sagt einem das niemand?“ Pluralität und Reflexivität für die schulische (sozio-)ökonomische Bildung
Authors: Beyer Marcel 
Published: November 2020

ZusammenfassungAnalog zur Bezugswissenschaft Ökonomik stellt sich auch in der universitären (sozio-)ökonomischen Lehrerbildung die Frage einer gelingenden Umsetzung und Etablierung von pluraler Ökonomik und epistemologischer Reflexion. Denn wenn angehende Lehrerinnen und Lehrer im Studium eine maßgeblich einseitige ökonomische Bildung erfahren, ihnen Alternativen im Denken und Handeln über Ökonomie vorenthalten werden, wie können diese dann Schülerinnen und Schüler befähigen, zentrale Probleme (Klimakrise, Ungleichheiten) multiperspektivisch zu befragen und anzugehen? Dieses Problem wird in meinem Beitrag einerseits vertieft, andererseits werden anhand eines fachdidaktischen Seminars in einem Bachelor-Studiengang konkrete Lösungsansätze für die Hochschullehre aufgezeigt. Dieses Seminar verfolgte das Ziel, Pluralität sowie Reflexivität zu den obersten Prämissen der fachwissenschaftlichen sowie fachdidaktischen Auseinandersetzung zu machen.
Teaching Feminist Economics. Conceptual Notes and Practical Advice for Teaching a Subject in the Making
Authors: Saave Anna 
Published: November 2020

AbstractTeaching feminist economics is a relatively new didactical project posing questions of content and methodology for instructors. The article proposes three possible topics with regard to the changing nature of the emergent research field: introducing feminist economics as a mode of questioning, showing its historicity and spectrum, and asking the question of a unifying paradigm. Complementarily, the article identifies teaching methodologies and aspects to consider for teaching according to feminist economics’ theoretical insights. This includes the role of experiences, the need for instructors to change perspectives, and the idea of caring and holding as starting points for a feminist pedagogy.
Einleitung
Authors: Krannich Sascha , Hunger Uwe 
Published: November 2020

ZusammenfassungDer Katholische Akademische Ausländer-Dienst (KAAD) fördert seit nunmehr sechs Jahrzehnten Studien- und Forschungsaufenthalte von jungen, begabten Menschen aus Afrika, Asien, dem Nahen Osten sowie Lateinamerika in Deutschland. Die Idee für dieses Stipendienwerk geht auf Diskussionen auf dem deutschen Katholikentag im Jahr 1954 in Fulda zurück. Hier wurden vor dem Hintergrund der jüngsten Erfahrungen des Zweiten Weltkriegs die ersten Überlegungen angestellt, eine Fördereinrichtung für Studierende aus sog. Entwicklungsländern (damals noch „Länder der Dritten Welt“) zu gründen.
Ergebnisse: Nach dem Studium
Authors: Krannich Sascha , Hunger Uwe 
Published: November 2020

ZusammenfassungSpannend ist es zu sehen, welche Wege die (ehemaligen) Stipendiat*innen nach ihrem Studium gegangen sind. Sind sie nach Beendigung des Studiums in Deutschland in ihr Herkunftsland zurückgegangen oder sind sie in Deutschland geblieben bzw. in ein anderes Land weitergewandert? Die Feldforschungen in den fünf Untersuchungsländern haben vielfältige Antworten auf diese Frage zum Vorschein gebracht. Es ist deutlich geworden, dass (ehemalige) internationale Studierende in ganz vielfältiger Weise und in verschiedenen (Migrations-)Formen zur Entwicklung in ihren Herkunftsländern beitragen.
The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes
Authors: Pichler K. M. , Weinmann D. , Schmidt S. , Kubista B. , Lass R. , Martelanz L. , Alphonsus J. , Windhager R. , Gabius H. -J. , Toegel S. 
Published: November 2020

AbstractThis work aimed to study the dysregulated network of galectins in OA chondrocyte pellets, and to assess whether their recently discovered activity as molecular switches of functional biomarkers results in degradation of extracellular matrix in vitro. Scaffold-free 3D pellet cultures were established of human OA chondrocytes. Expression and secretion of galectin(Gal)-1, -3, and -8 were monitored relative to 2D cultures or clinical tissue sections by RT-qPCR, immunohistochemistry and ELISAs. Exposure of 2D and 3D cultures to an in vivo-like galectin mixture (Gal-1 and Gal-8: 5 µg/ml, Gal-3: 1 µg/ml) was followed by the assessment of pellet size, immunohistochemical matrix staining, and/or quantification of MMP-1, -3, and -13. Application of inhibitors of NF-κB activation probed into the potential of intervening with galectin-induced matrix degradation. Galectin profiling revealed maintained dysregulation of Gal-1, -3, and -8 in pellet cultures, resembling the OA situation in situ. The presence of the galectin mixture promoted marked reduction of pellet size and loss of collagen type II-rich extracellular matrix, accompanied by the upregulation of MMP-1, -3, and -13. Inhibition of p65-phosphorylation by caffeic acid phenethyl ester effectively alleviated the detrimental effects of galectins, resulting in downregulated MMP secretion, reduced matrix breakdown and augmented pellet size. This study suggests that the dysregulated galectin network in OA cartilage leads to extracellular matrix breakdown, and provides encouraging evidence of the feasible inhibition of galectin-triggered activities. OA chondrocyte pellets have the potential to serve as in vitro disease model for further studies on galectins in OA onset and progression.
Software Engineering und Software-Engineering-Forschung im Zeitalter der Digitalisierung
Authors: Felderer Michael , Reussner Ralf , Rumpe Bernhard 
Published: November 2020

ZusammenfassungDie Digitalisierung und der damit verbundene digitale Wandel durchdringen alle Lebensbereiche. Qualitativ hochwertige Software ist der zentrale Baustein und Treiber der Digitalisierung. Damit nimmt auch das ingenieurmäßige Erstellen von Software, das Software Engineering, eine zentrale Rolle im digitalen Wandel ein und ist dabei selbst großen Veränderungen unterworfen. Dieser Artikel versucht deshalb eine Standortbestimmung des Software Engineering und seiner Forschung im Zeitalter der Digitalisierung vorzunehmen.
The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice
Authors: Batool Mehreen , Berghausen Eva M. , Zierden Mario , Vantler Marius , Schermuly Ralph T. , Baldus Stephan , Rosenkranz Stephan , ten Freyhaus Henrik 
Published: November 2020

AbstractSix-transmembrane protein of prostate (Stamp2) protects from diabetes and atherosclerosis in mice via anti-inflammatory mechanisms. As chronic inflammation is a hallmark of pulmonary arterial hypertension (PAH), we investigated the role of Stamp2. Stamp2 expression was substantially reduced in the lung of humans with idiopathic PAH, as well as in experimental PAH. In Stamp2-deficient mice, hypoxia modestly aggravated pulmonary vascular remodeling and right ventricular pressure compared to WT. As endothelial cell (EC) and pulmonary arterial smooth muscle cell (PASMC) phenotypes drive remodeling in PAH, we explored the role of Stamp2. Knock-down of Stamp2 in human EC neither affected apoptosis, viability, nor release of IL-6. Moreover, Stamp2 deficiency in primary PASMC did not alter mitogenic or migratory properties. As Stamp2 deficiency augmented expression of inflammatory cytokines and numbers of CD68-positive cells in the lung, actions of Stamp2 in macrophages may drive vascular remodeling. Thus, PASMC responses were assessed following treatment with conditioned media of primary Stamp2−/− or WT macrophages. Stamp2−/− supernatants induced PASMC proliferation and migration stronger compared to WT. A cytokine array revealed CXCL12, MCP-1 and IL-6 as most relevant candidates. Experiments with neutralizing antibodies confirmed the role of these cytokines in driving Stamp2’s responses. In conclusion, Stamp2 deficiency aggravates pulmonary vascular remodeling via cross-talk between macrophages and PASMC. Despite a substantial pro-inflammatory response, the hemodynamic effect of Stamp2 deficiency is modest suggesting that additional mechanisms apart from inflammation are necessary to induce severe PAH.
Functional investigation of the coronary artery disease gene SVEP1
Authors: Winkler Michael J. , Müller Philipp , Sharifi Amin M. , Wobst Jana , Winter Hanna , Mokry Michal , Ma Lijiang , van der Laan Sander W. , Pang Shichao , Miritsch Benedikt , Hinterdobler Julia , Werner Julia , Stiller Barbara , Güldener Ulrich , Webb Tom R. , Asselbergs Folkert W. , Björkegren Johan L. M. , Maegdefessel Lars , Schunkert Heribert , Sager Hendrik B. , Kessler Thorsten 
Published: November 2020

AbstractA missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) and vascular smooth muscle cells to represent the major cellular source of SVEP1 in plaques. Plaques were larger in atherosclerosis-prone Svep1 haploinsufficient (ApoE−/−Svep1+/−) compared to Svep1 wild-type mice (ApoE−/−Svep1+/+) and ApoE−/−Svep1+/− mice displayed elevated plaque neutrophil, Ly6Chigh monocyte, and macrophage numbers. We assessed how leukocytes accumulated more inside plaques in ApoE−/−Svep1+/− mice and found enhanced leukocyte recruitment from blood into plaques. In vitro, we examined how SVEP1 deficiency promotes leukocyte recruitment and found elevated expression of the leukocyte attractant chemokine (C-X-C motif) ligand 1 (CXCL1) in EC after incubation with missense compared to wild-type SVEP1. Increasing wild-type SVEP1 levels silenced endothelial CXCL1 release. In line, plasma Cxcl1 levels were elevated in ApoE−/−Svep1+/− mice. Our studies reveal an atheroprotective role of SVEP1. Deficiency of wild-type Svep1 increased endothelial CXCL1 expression leading to enhanced recruitment of proinflammatory leukocytes from blood to plaque. Consequently, elevated vascular inflammation resulted in enhanced plaque progression in Svep1 deficiency.
Modelling pyroclastic density currents from a subplinian eruption at La Soufrière de Guadeloupe (West Indies, France)
Authors: Esposti Ongaro Tomaso , Komorowski Jean-Christophe , Legendre Yoann , Neri Augusto 
Published: November 2020

AbstractWe have used a three-dimensional, non-equilibrium multiphase flow numerical model to simulate subplinian eruption scenarios at La Soufrière de Guadeloupe (Lesser Antilles, France). Initial and boundary conditions for computer simulations were set on the basis of independent estimates of eruption source parameters (i.e. mass eruption rate, volatile content, temperature, grain size distribution) from a field reconstruction of the 1530 CE subplinian eruption. This event is here taken as a reference scenario for hazard assessment at La Soufrière de Guadeloupe. A parametric study on eruption source parameters allowed us to quantify their influence on the simulated dynamics and, in particular, the increase of the percentage of column collapse and pyroclastic density current (PDC) intensity, at constant mass eruption rate, with variable vent diameter. Numerical results enabled us to quantify the effects of the proximal morphology on distributing the collapsing mass around the volcano and into deep and long valleys and to estimate the areas invaded by PDCs, their associated temperature and dynamic pressure. Significant impact (temperature > 300 °C and dynamic pressure > 1 kPa) in the inhabited region around the volcano is expected for fully collapsing conditions and mass eruption rates > 2 × 107 kg/s. We thus combine this spatial distribution of temperature and dynamic pressure with an objective consideration of model-related uncertainty to produce preliminary PDC hazard maps for the reference scenario. In such a representation, we identify three areas of varying degree of susceptibility to invasion by PDCs—very likely to be invaded (and highly impacted), susceptible to invasion (and moderately impacted), and unlikely to be invaded (or marginally impacted). The study also raises some key questions about the use of deterministic scenario simulations for hazard assessment, where probability distributions and uncertainties are difficult to estimate. Use of high-performance computing techniques will in part allow us to overcome such difficulties, but the problem remains open in a scientific context where validation of numerical models is still, necessarily, an incomplete and ongoing process. Nevertheless, our findings provide an important contribution to the quantitative assessment of volcanic hazard and risk at La Soufrière de Guadeloupe particularly in the context of the current unrest of the volcano and the need to prepare for a possible future reawakening of the volcano that could culminate in a magmatic explosive eruption.
Hybrid crow search and uniform crossover algorithm-based clustering for top-N recommendation system
Authors: El-Ashmawi Walaa H. , Ali Ahmed F. , Slowik Adam 
Published: November 2020

AbstractRecommender systems (RSs) have gained immense popularity due to their capability of dealing with a huge amount of information available in various domains. They are considered to be information filtering systems that make predictions or recommendations to users based on their interests. One of the most common recommender system techniques is user-based collaborative filtering. In this paper, we follow this technique by proposing a new algorithm which is called hybrid crow search and uniform crossover algorithm (HCSUC) to find a set of feasible clusters of similar users to enhance the recommendation process. Invoking the genetic uniform crossover operator in the standard crow search algorithm can increase the diversity of the search and help the algorithm to escape from trapping in local minima. The top-N recommendations are presented for the corresponding user according to the most feasible cluster’s members. The performance of the HCSUC algorithm is evaluated using the Jester dataset. A set of experiments have been conducted to validate the solution quality and accuracy of the HCSUC algorithm against the standard particle swarm optimization (PSO), African buffalo optimization (ABO), and the crow search algorithm (CSA). In addition, the proposed algorithm and the other meta-heuristic algorithms are compared against the collaborative filtering recommendation technique (CF). The results indicate that the HCSUC algorithm has obtained superior results in terms of mean absolute error, root means square errors and in minimization of the objective function.
Alternative Zuliefersysteme im Brauereisektor – Regionalmodelle des Braugerstenbezugs in Bayern
Authors: Maier Philipp , Klein Oliver , Schumacher Kim Philip 
Published: November 2020

ZusammenfassungSeit Jahrzehnten wird Bier größtenteils in standardisierten Wertschöpfungsketten produziert, wobei die Kontexte der Rohstofferzeugung kaum mehr nachvollziehbar erscheinen. Speziell in Bayern gibt es allerdings noch eine Vielzahl kleinerer Privatbrauereien, die alternative Zuliefersysteme mit direktem Kontakt zu regionalen Braugerstenerzeugern aufrechterhalten haben. Der vorliegende Beitrag widmet sich 5 solcher Brauereien und analysiert die Funktionsweisen, Koordinationsmechanismen und Erfolgsfaktoren der jeweiligen Regionalmodelle, die vorrangig auf reflexiven Sichtweisen der Brauereiverantwortlichen beruhen. Weitere Erfolgsfaktoren sind Transparenz und Authentizität, aber auch die Existenz von regionalen Mälzereien, deren Verarbeitungsstrukturen zum Bedarf der Brauereien passen. Der Regionalbezug von Braugerste kann zudem als Mittel der Produktdifferenzierung in einem umkämpften Biermarkt dienen.
Dear supplier, how sustainable are you?
Authors: Fraser Iain J. , Müller Martin , Schwarzkopf Julia 
Published: November 2020

AbstractThis article analyses one of the most common tools employed by global focal companies in sustainable supply chain management (SSCM) across all industries: supplier sustainability self-assessment questionnaires. Extant research has moved beyond the questions of whether and which suppliers should be assessed. Current research is already focussing on how to share and standardise such assessment data. Despite mounting general research on SSCM, we identified that specific tools such as self-assessment questionnaires have not been empirically analysed in SSCM literature. Thus, this paper addresses the research questions of what differences there are among supplier self-assessment questionnaires and how supplier responses to such questionnaires might be influenced. Our research involves an abductive multiple-case study design and an analysis of over 25,000 responses from globally dispersed suppliers to two types of supplier sustainability self-assessment questionnaires administered and requested by a global automotive focal company.Although the two questionnaires covered similar areas of sustainability practices and were administered to suppliers of the same focal company, the suppliers’ responses demonstrated various observable differences in average sustainability scores.Social desirability bias and supplier assessment fatigue were identified as issues confronting such questionnaires. We find that questionnaire design, how the questionnaire is embedded in the focal company’s processes and institutional settings are factors that potentially influence suppliers’ responses and could counteract social desirability bias and supplier assessment fatigue. Based on these findings we make suggestions for improving these SSCM tools and provide recommendations for further research.
Potential for managed aquifer recharge in southwestern Bangladesh based on social necessity and technical suitability
Authors: Naus Floris Loys , Schot Paul , van Breukelen Boris M. , Ahmed Kazi Matin , Griffioen Jasper 
Published: November 2020

AbstractIn southwestern Bangladesh, clean drinking water is scarce, since rainwater is only available during the monsoon, pond water is often bacteriologically polluted, and groundwater may exhibit high salinity and arsenic levels. Managed aquifer recharge (MAR) might potentially provide safe drinking water by storing abundant freshwater from the wet season in aquifers for year-round use. Regional potential for MAR was determined by combining assessments of (1) social necessity for MAR by mapping areas with insufficient drinking water of acceptable quality; (2) regional technical suitability by determining the (a) impact of density-driven flow on freshwater recovery efficiency, and (b) vulnerability of recovered water to mixing with contaminated groundwater. These assessments were based on the largest groundwater quality dataset compiled to date in southwestern Bangladesh, which contains 3,716 salinity and 827 arsenic measurements. The results show there is some mismatch between social necessity and technical suitability. In some northern areas, necessity is low because good quality groundwater is present and hence, despite the high technical suitability, potential for MAR is reduced. In other northern areas, groundwater with unsafe arsenic levels or brackish groundwater is likely used for drinking. There, MAR is a technically suitable and safer option. In southern areas, where saline groundwater is widespread and people consume bacterially unsafe pond water, the high groundwater salinity calls for careful evaluation of MAR design, for which this study presents practical guidelines. The approach developed may be useful for mapping MAR potential based on social necessity and technical suitability in other saline deltas worldwide.