bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Seafood Import Policy for Nations to Combat Illegal Fishing
Authors: Roberson Leslie , Hosch Gilles , Wilcox Chris , Domiguez‐Martinez Rosa Mar , Sant Glenn , Klein Carissa 
Published: February 2025

ABSTRACTThe environmental and social sustainability of seafood is jeopardized by rampant illegal, unreported, and unregulated fishing. Regulations implemented by fishing countries and Regional Fisheries Management Organizations are insufficient to combat illegal fishing; complementary efforts from the consumer end of the supply chain are essential. Despite the growing reliance on imported seafood globally, only three market states have implemented legislation to regulate the legality of seafood products from other countries. We provide an overview of existing import regulations to address widespread confusion about the structure and scope of these measures. We propose eight key design criteria for more effective seafood import controls, emphasizing the need for a centralized, fully electronic catch documentation scheme with automated fraud checks and a broad scope of species covered. Broad adoption of import controls across more countries can collectively enhance global efforts to curb illegal seafood trade. Countries developing new seafood import policies, such as Australia, have the opportunity to design a world‐leading system that encourages multilateral cooperation to help combat illegal fishing. Through the implementation of import regulations that address key flaws in existing frameworks, consumer countries can foster a more cohesive and effective front against illegally sourced seafood, improving the sustainability of global fisheries.
DEKODE—A cloud‐based performance feedback model improved DKA care across multiple hospitals in the UK
Authors: Rengarajan Lakshmi N. , Cooper Catherine , Malhotra Kashish , Sharma Angelica , Philip Nevil , Abraham Anu Ann , Dhatariya Ketan , Narendran Parth , Kempegowda Punith ,   DEKODE and DEVI Group
Published: February 2025

AbstractAimA current gap in Diabetes‐related ketoacidosis (DKA) research is understanding the factors contributing to variations in care and outcomes between people admitted with DKA. We aimed to create a system to facilitate gathering data on DKA management across multiple centres and identify trends in complications and outcomes associated with DKA.Research Design and MethodsBetween January 2020 and December 2022, we set up a cloud‐based Quality improvement project (QIP) that provided regular feedback to 11 hospitals in the United Kingdom (UK).ResultsOf the 1977 episodes, we observed an increase in adherence in fluid prescription in hospitals C, D, E, F and G (C‐ 23% vs. 75% p = <0.001; D‐ 27% vs. 60%, p = <0.001; E‐ 17 vs. 79% p = <0.001; F‐ 16% vs. 57%, p = <0.001; G‐ 36% vs. 75% p = <0.001). Notable improvements in adherence to glucose monitoring were observed in hospitals B, D, and G (B‐ 11 vs. 38% p = <0.001; D‐ 36% vs. 56%, p = 0.05; G‐ 22% vs. 67% p = <0.001). Although we didn't observe significant changes in complications and outcomes among participating hospitals from the start to the end of the reported period, notable fluctuations were evident across quarters. These variations were relayed to the respective hospitals, underscoring how feedback and interventions could influence the care provided. This initiative also marks the initial move towards establishing and improving data collection practices in acute diabetes.ConclusionsWe demonstrate a sustainable QIP that improves adherence to national guidelines in some indicators for DKA care and serves as an early warning system to identify adverse trends.
The Role of Phytophthora and Water Shortage in the Canker Disease of Corymbia calophylla as Determined by Reflectance Spectroscopy and Biophysical Variables
Authors: Croeser Louise , Admiraal Ryan , Barber Paul , Burgess Treena I. , Hardy Giles E. St. J. 
Published: February 2025

ABSTRACTCorymbia calophylla (marri), an iconic keystone species in the northern jarrah forest of southwestern Australia, is suffering from a stem canker disease caused by an endemic fungus, Quambalaria coyrecup. It is unusual for an endemic pathogen to have such a detrimental effect on a co‐evolved host, unless host defence mechanisms have been compromised. This study investigated the role of Phytophthora cinnamomi root infection and water shortage in predisposing C. calophylla to this canker disease, and whether these two stresses work synergistically to intensify the effect of the canker pathogen on C. calophylla. The roots of two‐year‐old C. calophylla plants were inoculated with P. cinnamomi in pot infestation trials, and 8 weeks later in the stems with the canker pathogen Q. coyrecup. Half of the plants were exposed to a water shortage treatment for the duration of the trial. Biophysical variables related to plant responses to the treatments were measured at harvesting. Reflectance spectroscopy measurements with a portable high‐resolution spectroradiometer were also taken weekly. The normalised difference spectral index (NDSI) was calculated for every combination of reflectance values between 350 nm and 2500 nm for all time points, correlated with treatment effects, and displayed as heat maps. Fifty‐seven vegetation indices (VIs), using wavelengths from different regions in the electromagnetic spectrum, were also calculated from the spectral data. Neither P. cinnamomi nor the water shortage treatments exacerbated the effect of the canker pathogen on the plants. The canker treatment increased plant stem diameter and canker volume significantly (p < 0.001). The NDSI heat maps indicated that wavelengths in the electromagnetic spectrum's visible and shortwave infrared portions displayed the strongest correlations with the P. cinnamomi and water shortage treatments. For the canker treatment, it was the shortwave infrared portion. Six of the VIs responded significantly to the water shortage treatment: Carter index 1 (p < 0.001), renormalised difference vegetation index (p < 0.001), normalised difference water index (p = 0.012), normalised phaeophytinization index (p < 0.001), photochemical reflectance index (p < 0.001) and red‐green ratio index (p = 0.018). The renormalised difference vegetation index was also sensitive to the canker treatment (p < 0.001), and the Carter index 1 to the P. cinnamomi treatment (p < 0.001). Reflectance spectroscopy was able to track biochemical changes in C. calophylla leaves due to inoculation with P. cinnamomi, Q. coyrecup, and the water shortage treatment. However, more work must be done to identify optimum wavelengths specific to C. calophylla and its responses to pathogens.
Carbon‐Based Particles Inhibit Antigen Penetration Into the Skin by Adsorbing the Antigen
Authors: Ichinohe Rin , Segawa Ryosuke , Nakajo Takahisa , Hiratsuka Masahiro , Yoshii Takeharu , Pirabul Kritin , Pan Zhen‐Ze , Nishihara Hirotomo , Hirasawa Noriyasu 
Published: February 2025

ABSTRACTIn most cases, atopic dermatitis (AD) is induced by allergic inflammation, with antigen penetration into the epithelial tissues of the skin being the first step in AD development. Accordingly, inhibiting the skin penetration of antigens is effective in preventing AD. We evaluated the ability of the following four types of particles to adsorb ovalbumin (OVA): titanium dioxide (TiO2), silicon dioxide (SiO2), carbon, and SiO2 coated with one‐layer graphene (1LGCS). We found that metal oxide particles (TiO2 and SiO2) could adsorb OVA at pH 5.0, but their abilities decreased at pH 7.0 and 9.0. In contrast, the carbon‐based particles (carbon and 1LGCS) adsorbed OVA regardless of pH changes. Epicutaneous treatment with OVA resulted in an increase in the proportion of OVA‐positive Langerhans cells and dermal dendritic cells in the lymph nodes, along with elevated interleukin‐4 mRNA expression, indicating that OVA penetrated the epidermis and underlying tissues. When OVA was applied together with the particles, these responses were significantly reduced by the carbon‐based particles but were only partially or not inhibited by metal oxide particles. These findings indicated that antigen penetration was potently inhibited by the carbon‐based particles. Additionally, when mice were epicutaneously sensitised and challenged with OVA in the presence of carbon, the increase in OVA‐specific IgG1 and IgE levels was significantly inhibited. The efficiency of carbon‐based particles may be attributed to their stable adsorption of proteins despite pH changes on the skin surface. These findings may lead to the development of new treatments for AD with fewer side effects.
Dose Modulation Strategies in Psoriatic Patients: Real‐Life Pilot Comparison Between Risankizumab and Guselkumab up to 12 Months After Dose Spacing
Authors: Mastorino Luca , Dapavo Paolo , Ortoncelli Michela , Bongiovanni Eleonora , Liao Yingying , Leo Francesco , Quaglino Pietro , Ribero Simone 
Published: February 2025

ABSTRACTThe possibility of modulating the treatment regimen regarding dose reduction (de‐escalation) or dose augmentation (escalation) in psoriasis biological treatment has been of increasing interest. De‐escalation strategies include reducing the single therapeutic dose, the mg/kg ratio or the number of injections, or dose‐spacing (D‐S), that is, extending the interval between administrations. Data regarding dose de‐escalation, in particular D‐S, on IL‐23, are lacking to date. The present pilot study is a cohort study with a retrospective analysis of the general characteristics and effectiveness outcomes of psoriatic patients undergoing therapeutic biologic D‐S of risankizumab and guselkumab. Ninety‐four patients, 32 (34.04%) treated with guselkumab and 62 (65.96%) treated with risankizumab, underwent dose modulation by D‐S of 50% of the approved range. The mean PASI decreased from 12.15 (5.43 SD) to 0.15 (0.46 SD) at D‐S time. Attainment of PASI100 was rapid: 88.3% at the D‐S date, remaining stable over the following year, reaching 100% of patients observed 12 months after D‐S. Similar is the trend for PASI 90 and PASI <=1 with 91.49% and 97.87% of achievement at D‐S date, and all patients observed at 12 months post‐D‐S. The 12‐month drug survival of the D‐S regimen was 89.4%. Guselkumab showed a D‐S drug survival of 93.3% versus 89.5% of risankizumab. No differences in mean PASIs at each time point were found between guselkumab and risankizumab. To conclude therapeutic modulation of IL‐23 inhibitors in psoriatic patients who have achieved response stability seems a legitimate therapeutic strategy to maintain efficacy and safety.
From pipettes to playdates: establishing a parent support group in a research setting
Authors: Longley Rhea J , Samson Andre L , Atkin‐Smith Georgia , Carey Hulyer Alex R , Ashton Trent , Davidson Nadia M 
Published: February 2025

AbstractIn this article, we discuss our experiences and perspectives in forming a workplace Parents Group. We reflect on the need for these networks, what has worked well, and the challenges we’ve experienced. We also provide some practical advice for those with parenting‐related career disruptions for addressing this topic in grant applications.
The Impact of Higher Education Service Quality on Institutional Image and Student Satisfaction: The Role of Institutional Image as Mediator
Authors: Hossain Md Alamgir , Wu Renhong , Kalam Abul , Al Masud Abdullah , Islam Tarannum , Nur Habib Sadia 
Published: February 2025

ABSTRACTMeasurement of student satisfaction and institutional image was frequently a challenge for stakeholders in higher education. The current study looks into how different institutional services in higher education impact institutional image and student satisfaction. A standardized questionnaire was employed in a self‐administered online survey to gather information, and 302 valid samples were then evaluated using a structural equation model. Empirical results indicate that teachers’ profiles, syllabus and curriculum, research activities, economic value, institutional facilities and management policies are the main influencers of institutional image and student satisfaction. Additionally, the findings indicate that the institutional image has a significant direct and mediating impact on student satisfaction. It is undeniable that contextual service‐driven constituents have a beneficial impact on both students’ perceptions of their academic lives and the institution's reputation. Given this, the current study could aid higher education institutions (HEIs) in offering competitive services pertaining to institutional image and student happiness, enabling them to achieve a sustained competitive edge over their competitors.
DLP 3D‐printing of dual porous YSZ ceramics with high mechanical properties using PMMA microsphere as pore‐forming agent
Authors: Liu Yansong , Liu Yongsheng , Cao Yejie , Zheng Xiang , Sun Xiaokun , Xu Yang 
Published: February 2025

AbstractDual porous yttria‐stabilized zirconia (YSZ) ceramics were fabricated via digital light processing (DLP) additive manufacturing using polymethyl methacrylate (PMMA) microspheres as pore‐forming agent for the first time. The results showed that the introduction of PMMA microspheres effectively reduced the viscosity of the photosensitive YSZ ceramic slurry used in DLP printing, improved the cured depth of the slurry, and did not exert a strong influence on stability. After sintering at 1400°C, pores with dual scales were generated in the ceramics, while exhibiting the optimal physical and mechanical properties. With the increase of PMMA content from 0 to 40 vol%, the open porosity increased from 1.96% to 34.06% and the density decreased from 5.92 to 3.82 g/cm3, respectively. The compressive strength and thermal conductivity of porous ceramics decreased from 350.54 to 99.85 MPa and from 2.80 to 1.46 W/(m⋅K), respectively. This investigation opens up new prospects for the fabrication of porous YSZ ceramics with low thermal conductivity and high mechanical properties.
EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood
Authors: Sacks Dashiell D. , Wang Yiyi , Abron Asja , Mulligan Kaitlin M. , Kelsey Caroline M. , Xie Wanze , Nelson Charles A. , Bosquet Enlow Michelle 
Published: February 2025

BackgroundAnxiety and depression are highly prevalent in youth and can cause significant distress and functional impairment. The presence of maternal anxiety and depression are well‐established risk factors for child internalizing psychopathology, yet the responsible mechanisms linking the two remain unclear.MethodsWe examined the potential mediating and moderating roles of EEG frontal alpha asymmetry (FAA) in the intergenerational transmission of internalizing symptoms in a longitudinal sample of N = 323 mother–child dyads. Self‐report maternal internalizing symptoms were evaluated at child age 3 years and 5 years, child EEG at 5 years, and parent‐report child internalizing symptoms at age 7 years. Mediation was evaluated via bootstrapped (N = 5,000) confidence intervals.ResultsWe found significant associations among maternal internalizing (anxiety, depressive) symptoms when their children were ages 3 and 5 years, child FAA at age 5 years, and child internalizing symptoms at age 7 years. There was a significant mediation effect, whereby greater maternal anxiety and depressive symptoms at age 3 years were significantly associated with FAA (greater relative right cortical activation) in children at age 5 years, which, in turn, was significantly associated with greater child internalizing symptoms at age 7 years (ps < .001). There was no moderating effect of FAA on the association between maternal internalizing symptoms at age 5 years and child internalizing symptoms at age 7 years.ConclusionsGreater right frontal asymmetry may be a neurophysiological mechanism that mediates the intergenerational transmission of internalizing symptoms.
Using Item Parameter Predictions for Reducing Calibration Sample Requirements—A Case Study Based on a High‐Stakes Admission Test
Authors: Ulitzsch Esther , Belov Dmitry , Lüdtke Oliver , Robitzsch Alexander 
Published: February 2025

AbstractIn item difficulty modeling (IDM), item parameters are predicted from the items' linguistic features, aiming to ultimately render item calibration redundant. Current IDM applications, however, commonly do not yield the required prediction accuracy. To immediately exploit even somewhat inaccurate IDM predictions, we blend IDM with established Bayesian estimation techniques. We propose a two‐step approach where (1) IDM predictions are obtained and (2) employed to construct informative prior distributions. We evaluate the approach in a case study on small‐sample calibration of the 3PL in a high‐stakes test. First, concerning implementation, we find computationally efficient penalized maximum likelihood estimation to be comparable to the best‐performing MCMC‐based approach. Second, we investigate sample size reductions achievable with state‐of‐the‐art IDM predictions, finding negligible gains compared to merely considering the historical distribution of parameters. Third, we evaluate the prediction accuracy required for a targeted sample size reduction by gradually increasing simulated IDM prediction accuracies. We find that required accuracies can counterbalance each other, allowing calibration sample size to be reduced when either high‐quality item difficulty predictions or good predictions of item discriminations and pseudo‐guessing parameters are available. We argue that these evaluations provide new, portable IDM benchmarks quantifying performance in terms of achievable sample size reductions.
Capturing Real‐World Rare Disease Patient Journeys: Are Current Methodologies Sufficient for Informed Healthcare Decisions?
Authors: Cribbs Kristen A. , Blackmore Lucas T. A. , Banks Asia R. , Kim Da Sol , Lahue Betsy J. 
Published: February 2025

ABSTRACTRationaleDespite growing emphasis among healthcare decision‐makers on patient perspectives and real‐world outcomes to inform care and access decisions, understanding of patient journey experiences in rare diseases remains limited due to data collection and evaluation challenges.Aims and ObjectivesThis systematic literature review (SLR) assessed study designs, methodologies, and outcomes reported in real‐world investigations of rare disease patient journeys.MethodsSearches in PubMed and Google Scholar targeted English‐language publications and congress proceedings from 1 January 2014, to 30 April 2024, including rare disease patients, caregivers, or healthcare providers. Keywords included ‘Journey’, ‘Path’, or ‘Odyssey’. Two reviewers independently assessed eligibility and abstracted data. Descriptive analyses and quality assessments were conducted.ResultsThirty‐one studies met inclusion criteria, with 296,548 participants spanning over 600 rare diseases. Most studies used prospective observational (61%) and cross‐sectional (26%) designs and were conducted in Europe (45%). Interviews (39%) and surveys (29%) were common methodologies. Patients (87%) were the primary research focus, compared to caregivers (32%) or providers (10%). The most studied journey stages were ‘Pre‐diagnosis/Screening’ (97%) and ‘Diagnosis’ (84%), while ‘Disease Awareness’ (16%) and ‘Treatment Adherence’ (6%) were less common. Across 164 outcomes reported, frequent outcomes included ‘Healthcare Resource Utilization’ (94%), ‘Symptoms’ (74%), and ‘Time‐to‐Diagnosis’ (71%). Fewer studies reported ‘Costs’ (19%), ‘Caregiver/Family Burden’ (16%), and ‘Productivity’ (13%). Time‐to‐diagnosis averaged 11.8 years and a median of 6.1 years. All but one study (97%) was rated low or very low quality due to observational designs.ConclusionMost rare disease patient journey evidence focuses on ‘Pre‐diagnosis/Screening’ and ‘Diagnosis’ stages using qualitative methods and surveys. While symptoms, time‐to‐diagnosis, and resource utilization were commonly reported, evidence gaps included treatment adherence, caregiver burden and productivity. Longitudinal assessments to collect real‐world care and treatment burden outcomes, including caregiver perspectives, can enhance both clinician and policy decision‐making for individuals living with rare diseases.
Borderline Intellectual Functioning: A Scoping Review
Authors: Orío‐Aparicio Cristina , López‐Escribano Carmen , Bel‐Fenellós Cristina 
Published: February 2025

ABSTRACTBackgroundBorderline intellectual functioning (BIF) is a condition that involves limitations in cognitive skills that affect the daily functioning of people who present it. BIF has lost visibility in diagnostic manuals such as the DSM‐5‐TR and ICD‐11, which relegate it to complementary categories of aspects requiring attention, rather than recognising it as a category of its own. This lack of recognition as well as unclear criteria for diagnosis underscores the need for a deeper understanding of BIF.MethodThe study conducted a scoping review to map the available evidence in the field of BIF. Following the PRISMA‐ScR framework, ProQuest, WoS, SCOPUS and EBSCOhost databases were searched. Documents were selected based on inclusion criteria: date of publication (since 2012), study of BIF as a specific group and language (English or Spanish). A total of 138 documents were included, both academic and grey literature.ResultsThe review mapped the literature into key categories: intellectual functioning, adaptive functioning and additions for a comprehensive evaluation. Most research focused on comorbid psychiatric, emotional and behavioural disorders associated with BIF, as well as cognitive aspects. Very few addressed adaptive functioning explicitly, a crucial area for diagnosing and supporting individuals with BIF, though many covered its domains (conceptual, social and practical). Studies predominantly used quantitative methodologies, with only a few incorporating qualitative methods and directly involving people with BIF.ConclusionsThe review emphasises the need for a clearer definition of BIF. Future studies should incorporate the perspectives of individuals with BIF to fully understand their needs and challenges across various life domains.