bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Devonian (415–400 Ma) A-type granitoids and diabases in the Wuyishan, eastern Cathaysia: A signal of crustal extension coeval with the separation of South China from Gondwana
Authors: Xin Yujia , Li Jianhua , Ratschbacher Lothar , Zhao Guochun , Zhang Yueqiao , Dong Shuwen , Xia Xiao-Ping , Yu Yingqi 
Published: March 2020

AbstractThe evolution of the South China continental crust and its linkage to the assembly and rifting of eastern Gondwana are key issues in the understanding of the early Paleozoic evolution of eastern Asia. We report U-Pb zircon ages and geochemical and Lu-Hf isotopic data for the South Fufang and Yingshang granitoids and the Mayuan diabases from the Wuyishan of eastern South China. The zircons yielded U-Pb ages of ca. 414–404 and ca. 409–401 Ma for the granitoids and diabases, respectively. Petrographic and geochemical features indicate that the granitoids are peraluminous A-type granites, expressed by high Ga/Al ratios and high Zr, Nb, Ce, Y, and rare earth element contents. They show negative zircon εHf(t) values (–15.4 to –5.8), consistent with the derivation from a crustal source. The granitoids likely originated from partial melting of dry granulite residues in the lower crust. The diabases show depletion in Ti, and negative correlations between FeOt and Mg#, and SiO2 and TiO2/FeOt, reflecting clinopyroxene, olivine, and Fe-Ti oxide fractionation. Their negative zircon εHf(t) values (–4.5 to –0.4) indicate an ancient enriched-mantle origin. The diabases likely originated from partial melting of a sub-continental lithospheric mantle. We interpret these A-type granitoids and diabases as post-orogenic, formed during extensional collapse of thickened crust. Their generation indicates that South China experienced crustal extension during the Early Devonian. The extension occurred coevally with global rifting that led to the separation of the continental blocks of eastern Asia from eastern Gondwana, which was associated with the Early Devonian opening of the paleo–Tethys Ocean.
The effect of cooling during deformation on recrystallized grain-size piezometry
Authors: Soleymani Hamid , Kidder Steven , Hirth Greg , Garapić Gordana 
Published: March 2020

AbstractMost exposed middle- and lower-crustal shear zones experienced deformation while cooling. We investigated the effect of the strengthening associated with such cooling on differential stress estimates based on recrystallized grain size. Typical geologic ratios of temperature change per strain unit were applied in Griggs Rig (high pressure-temperature deformation apparatus) general shear experiments on quartzite with cooling rates of 2–10 °C/h from 900 °C to 800 °C, and a shear strain rate of ∼2 × 10−5 s−1. Comparisons between these “cooling-ramp” experiments and control experiments at constant temperatures of 800 °C and 900 °C indicated that recrystallized grain size did not keep pace with evolving stress. Mean recrystallized grain sizes of the cooling-ramp experiments were twice as large as expected from the final stresses of the experiments. The traditional approach to piezometry involves a routine assumption of a steady-state microstructure, and this would underestimate the final stress during the cooling-ramp experiments by ∼40%. Recrystallized grain size in the cooling-ramp experiments is a better indicator of the average stress of the experiments (shear strains ≥3). Due to the temperature sensitivity of recrystallization processes and rock strength, the results may underrepresent the effect of cooling in natural samples. Cooling-ramp experiments produced wider and more skewed grain-size distributions than control experiments, suggesting that analyses of grain-size distributions might be used to quantify the degree to which grain size departs from steady-state values due to cooling, and thereby provide more accurate constraints on final stress.
Large-scale stable isotope characterization of a Late Cretaceous dinosaur-dominated ecosystem
Authors: Cullen T.M. , Longstaffe F.J. , Wortmann U.G. , Huang L. , Fanti F. , Goodwin M.B. , Ryan M.J. , Evans D.C. 
Published: March 2020

Abstract
In the Cretaceous of North America, environmental sensitivity and habitat specialization have been hypothesized to explain the surprisingly restricted geographic ranges of many large-bodied dinosaurs. Understanding the drivers behind this are key to determining broader trends of dinosaur species and community response to climate change under greenhouse conditions. However, previous studies of this question have commonly examined only small components of the paleo-ecosystem or operated without comparison to similar modern systems from which to constrain interpretations. Here we perform a high-resolution multi-taxic δ13C and δ18O study of a Cretaceous coastal floodplain ecosystem, focusing on species interactions and paleotemperature estimation, and compare with similar data from extant systems. Bioapatite δ13C preserves predator-prey offsets between tyrannosaurs and ornithischians (large herbivorous dinosaurs), and between aquatic reptiles and fish. Large ornithischians had broadly overlapping stable isotope ranges, contrary to hypothesized niche partitioning driven by specialization on coastal or inland subhabitat use. Comparisons to a modern analogue coastal floodplain show similar patterns of ecological guild structure and aquatic-terrestrial resource interchange. Multi-taxic oxygen isotope temperature estimations yield results for the Campanian of Alberta (Canada) consistent with the few other paleotemperature proxies available, and are validated when applied for extant species from a modern coastal floodplain, suggesting that this approach is a simple and effective avenue for paleoenvironmental reconstruction. Together, these new data suggest that dinosaur niche partitioning was more complex than previously hypothesized, and provide a framework for future research on dinosaur-dominated Mesozoic floodplain communities.
Reduced stereoacuity as a predictor for clinically significant convergence insufficiency
Authors: Leshno Ari , Stolovitch Chaim , Zloto Ofira , Blum Meirovitch Sharon , Mezad-Koursh Daphna 
Published: March 2020

BackgroundStereoacuity relies on accurate binocular alignment. Convergence insufficiency (CI) a binocular motor disorder, interferes with near work.ObjectiveTo investigate the association between convergence amplitude (CA) and stereoacuity in a large paediatric cohort.MethodsRetrospective chart review included patients aged 6–17 years; excluded patients with amblyopia, manifest strabismus or visual acuity <20/30 in either eye. Stereoacuity, measured by Randot test was defined as normal (≤40arcsec), subnormal (50–400arcsec) and poor (>400 arcsec). CA, measured using base out prism bar was defined by fusion break point (BP) and recovery point (RP), as none (BP=0), poor (BP <20 prism diopter (PD)), borderline (BP <30 PD or RP <20 PD), good (BP ≥30 PD and RP ≥20 PD) and excellent (does not break at 40PD).ResultsIn 2200 subjects included, we found an increased prevalence of normal stereoacuity as convergence ability improves (χ2 test, p<0.001) with a negative correlation between stereoacuity and BP (Pearson correlation −0.13, p<0.001).CI was significantly associated with below normal stereopsis OR 1.86 (95% CI 1.3 to 2.7, p<0.001). Conversely, prevalence of CI was similar, whether or not CI-symptoms were reported. Follow-up data of at least 2.5 years from presentation was available for a small subgroup of 21 patients treated for CI. Convergence improved in 14 (66%), rate of normal stereoacuity increased from 29% at baseline to 76% at last follow-up (p=0.006).ConclusionsCA affects stereoacuity function in children. Evaluation of CA is required in all cases with poor stereoacuity, especially when other etiologies are amiss. The role of convergence improvement exercise on stereoacuity warrants further investigation.
Prevalence of myopic macular degeneration worldwide: a systematic review and meta-analysis
Authors: Zou Minjie , Wang Shibin , Chen Aiming , Liu Zhenzhen , Young Charlotte Aimee , Zhang Yichi , Jin Guangming , Zheng Danying 
Published: March 2020

PurposeTo investigate the prevalence of myopic macular degeneration (MMD) in the global population.MethodsAll published literature of population-based studies on MMD prevalence worldwide were searched and only those with clear definitions to diagnose and classify MMD lesions by standardised grading methods were selected. Meta-analysis methods were used to calculate the pooled prevalence of MMD and its 95% CI in a random-effects model. The prevalence of MMD lesions would also be reported, together with the subgroup analysis of age, region and gender. Correlation between MMD prevalence and spherical equivalent levels and axial length were also evaluated.Results12 studies with 58 558 subjects were included in this meta-analysis. The pooled prevalence of MMD in the world population was 2.1% (95% CI: 1.3% to 3.3%). In the subgroup analysis, people with the following characteristics were at higher risk of developing MMD: female, urban life, living in Asia, older age, longer axial length and severer myopia.ConclusionsMMD is a serious public health concern worldwide, particularly in subjects who are women, subjects living in urban areas, subjects living in Asia, and subjects with longer axial lengths and severer myopia. Further studies from other continents/ethnicities are needed for comprehensive estimates of the prevalence of MMD globally.
Indications and prognosis for keratoplasty in eyes with severe visual impairment and blindness due to corneal disease in India
Authors: Das Anthony Vipin , Basu Sayan 
Published: March 2020

PurposeTo describe the indications and prognosis for keratoplasty in eyes with severe visual impairment and blindness due to corneal diseases in India.MethodsThis hospital-based cross-sectional study included 1 057 215 new patients presenting to a multitier ophthalmology network from 2016 to 2018. All patients with a central corneal pathology and best corrected visual acuity of less than 20/200 in the affected eye(s) were identified as cases and grouped according to laterality. The main outcome measure was the prognosis for keratoplasty, based on the surgical indication.ResultsA total of 28 824 (2.73%) patients were identified with severe visual impairment or blindness due to corneal diseases; of which, 22 582 (78.3%) had unilateral and 6242 (21.7%) had bilateral affliction. Overall, 85% of the corneal pathologies were due to avoidable causes, which accounted for 97% and 63% of the unilateral and bilateral cases, respectively (p<0.0001). The most common aetiologies were microbial keratitis (27.2%) and corneal opacification (25.5%) in unilateral cases; and corneal opacification (38.2%) and ectasias (14.5%) in bilateral cases. Overall, 60.1% of affected eyes carried a fair to poor prognosis for keratoplasty. However, while in unilateral cases only 29.9% of eyes carried good to excellent prognosis for keratoplasty, in bilateral cases, 58% of eyes carried good to excellent prognosis for keratoplasty (p<0.0001).ConclusionsThe indications and prognosis for keratoplasty varied greatly based on whether the affliction was unilateral or bilateral. Most of the eyes affected by corneal visual impairment or blindness, however, carried an unfavourable prognosis for keratoplasty.
Prevalence and genetic–phenotypic characteristics of patients with USH2A mutations in a large cohort of Chinese patients with inherited retinal disease
Authors: Gao Feng-Juan , Wang Dan-Dan , Chen Fang , Sun Hao-Xiang , Hu Fang-Yuan , Xu Ping , Li Jiankang , Liu Wei , Qi Yu-He , Li Wei , Wang Ming , Zhang Shenghai , Xu Ge-Zhi , Chang Qing , Wu Ji-Hong 
Published: March 2020

AimsTo investigate the frequency of USH2A mutation and the clinical and genetic differences between Usher syndrome type II (USH2) and retinitis pigmentosa (RP) in a large cohort of Chinese patients.MethodsA total of 1381 patients with inherited retinal disease (IRD) were recruited. The phenotypic and genotypic information of patients with USH2A mutations was evaluated.ResultsThe prevalence of patients with USH2A mutations was 15.75%, which was the most frequently detected gene in this cohort of patients. Hotspot of USH2A mutations was c.8559-2A >G and c.2802T >G. Patients with USH2 had an earlier and more serious decline of visual function and damage to retina structure than did patients with RP in the first 10 years (p<0.05), but there was no difference in the visual prognosis between the two groups when the course of disease exceeded 10 years (p>0.05). Missense variants had less severe consequences and were found more commonly in RP, whereas more deleterious genotypes were associated with an earlier onset of disease and were found more commonly in USH2.ConclusionsThis study provides detailed clinical–genetic assessment of patients with USH2A mutations of Chinese origin, enabling precise genetic diagnoses, better management of these patients and putative therapeutic approaches.
Prevalence and clinical features of systemic diseases in Chinese patients with uveitis
Authors: Yang Peizeng , Zhong Zhenyu , Du Liping , Li Fuzhen , Chen Zhijun , Zhu Ying , Zhang Wanyun , Huang Fanfan , Ye Xingsheng , Su Guannan , Kijlstra Aize 
Published: March 2020

PurposeSystemic diseases are frequently associated with uveitis but are often not recognised by clinicians. An estimate of the prevalence in a large-scale uveitis population is essential for understanding the epidemiological profile and may be helpful for clinical practice.DesignA nationwide survey.MethodsData were obtained from a national database which included the registration of uveitis cases from 23 provinces, 5 autonomous regions and 4 municipalities across mainland China. The primary outcome was identification of a systemic disease associated with uveitis.ResultsFrom April 2008 through August 2018, 15 373 uveitis patients were included in the study. Males accounted for 52.9%, and the mean (SD) age of uveitis onset was 35.4 (15.9) years. After standardisation for age, the prevalence of systemic disease among patients with uveitis was 30.8% (95% CI, 30.1% to 31.6%). Vogt-Koyanagi-Harada disease (VKH; age-standardised prevalence, 12.7%; 95% CI, 12.1% to 13.2%), Behçet’s disease (BD; 8.7%; 95% CI, 8.3% to 9.2%), ankylosing spondylitis (AS; 5.0%; 95% CI, 4.6% to 5.3%) and juvenile idiopathic arthritis (JIA; 1.2%; 95% CI, 1.0% to 1.3%) were the most common entities among 36 different forms of systemic diseases identified. The prevalence was significantly higher in males (37.0%; 95% CI, 36.0% to 38.1%) than in females (23.6%; 95% CI, 22.6% to 24.6%), and also higher in bilateral uveitis patients (41.2%; 95% CI, 40.2% to 42.2%) compared with unilateral cases (14.3%; 95% CI, 13.4% to 15.2%), and was highest in panuveitis (59.5%; 95% CI, 58.2% to 60.8%).ConclusionApproximately one third of uveitis patients in this nationwide survey have an associated systemic disease, whereby VKH, BD, AS and JIA are the most frequent entities seen in China.
Efficacy and effectiveness studies of depression are not well-differentiated in the literature: a systematic review
Authors: Schmaling Karen , Kaplan Robert M , Porzsolt Franz 
Published: March 2020

Background
In the literature on the treatment of depression, efficacy and effectiveness research have different purposes and should apply different research methodologies.

Objective
The purpose of the study was to review characteristics of depression treatment studies identified using efficacy or effectiveness search terms. We considered subject inclusion and exclusion criteria; numbers of subjects enrolled and the proportion in the primary analyses; inclusion of a Consolidated Standards of Reporting Trials (CONSORT) flow diagram; use of random assignment; use of placebo control conditions; lengths of treatment and follow-up; primary outcome variable; trial registration; journal impact factor.

Study selection
Studies indexed as efficacy AND ‘real-world’ AND depression or effectiveness AND ‘real-world’ AND depression in PubMed up to 18 May 2019.

Findings
27 studies met the inclusion criteria: 13 effectiveness studies, 6 efficacy studies and 8 studies indexed as both effectiveness and efficacy. Studies identified as effectiveness, efficacy, or both differed on three outcome measures: the inclusion criteria were lengthier for efficacy than for effectiveness studies; efficacy studies were more likely to have a placebo control condition than effectiveness studies; and the journal impact factor was lower for effectiveness studies than for studies from the efficacy search or studies identified by both searches.

Conclusions
Efficacy and effectiveness research hypothetically use different methodologies, but the efficacy and effectiveness literatures in the treatment of depression were comparable for most of the coded characteristics. The lack of distinguishable characteristics suggests that variably applied terminology may hinder efforts to narrow the gap between research and practice.

PROSPERO registration number
#CRD42019136840.
Strategies to reduce the impact of demand for concurrent endovascular thrombectomy
Authors: Dalsania Ankur K , Kansagra Akash P 
Published: March 2020

BackgroundThe rise in demand for endovascular thrombectomy (EVT) has increased the possibility that multiple patients with acute ischemic stroke may present concurrently and exceed local capacity to provide timely treatment. In this work, we quantitatively compared the efficacy of various strategies to mitigate demand in excess of capacity (DEC).MethodsStrategies evaluated included a backup neurointerventional team for 3 hours, 8 hours, or 24 hours per day; a separate pre-intervention imaging team; and a 30% decrease in procedure duration. For each strategy, empirical distributions were used to probabilistically generate arrival time and case duration for 16 000 independent trials repeated across a range of annual case volumes. DEC was calculated from time series representing the number of concurrent cases at each minute of the year for each trial at each case volume.ResultsAll strategies decreased DEC compared with baseline. At a representative volume of 250 cases per year, availability of a backup team for 3 hours, 8 hours, and 24 hours per day reduced DEC by 27.0%, 60.3%, and 97.2%, respectively, compared with baseline. Similarly, availability of a pre-intervention imaging team and a 30% decrease in procedure duration reduced DEC by 26.6% and 17.7%, respectively, compared with baseline.ConclusionsA backup neurointerventional team, even if available only part time, was an effective strategy for decreasing DEC for EVT. Understanding the actual quantitative benefit of each strategy can facilitate rational cost–benefit analyses underlying the development of efficient and sustainable models of care.
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017
Authors: Shi Peng , Xing Xiaoyue , Xi Shuhua , Jing Hongmei , Yuan Jiamei , Fu Zhushan , Zhao Hanqing 
Published: March 2020

ObjectivesPneumoconiosis remains a major global occupational health hazard and illness. Accurate data on the incidence of pneumoconiosis are critical for health resource planning and development of health policy.MethodsWe collected data for the period between 1990 and 2017 on the annual incident cases and the age-standardised incidence rates (ASIR) of pneumoconiosis aetiology from the Global Burden of Disease Study 2017. We calculated the average annual percentage changes of ASIR by sex, region and aetiology in order to determine the trends of pneumoconiosis.ResultsGlobally, the number of pneumoconiosis cases increased by a measure of 66.0%, from 36 186 in 1990 to 60 055 in 2017. The overall ASIR decreased by an average of 0.6% per year in the same period. The number of pneumoconiosis cases increased across the five sociodemographic index regions, and there was a decrease in the ASIR from 1990 to 2017. The ASIR of silicosis, coal workers’ pneumoconiosis and other pneumoconiosis decreased. In contrast, measures of the ASIR of asbestosis displayed an increasing trend. Patterns of the incidence of pneumoconiosis caused by different aetiologies were found to have been heterogeneous for analyses across regions and among countries.ConclusionIncidence patterns of pneumoconiosis which were caused by different aetiologies varied considerably across regions and countries of the world. The patterns of incidence and temporal trends should facilitate the establishment of more effective and increasingly targeted methods for prevention of pneumoconiosis and reduce associated disease burden.
HIV and other sexually transmitted infections among female sex workers in Moscow (Russia): prevalence and associated risk factors
Authors: Bernier Adeline , Rumyantseva Tatiana , Reques Laura , Volkova Natalia , Kyburz Yan , Maximov Olga , Derrienic Eve , Guschin Alexander , Bouscaillou Julie , Luhmann Niklas , Pataut Dominique 
Published: March 2020

To estimate the prevalence and factors associated with HIV and five other STIs among outdoor female sex workers (OSFW) and indoor FSW (IFSW).MethodsCross-sectional survey using respondent-driven sampling methodology. Participants answered a bio-behavioural questionnaire and were tested forNeisseria gonorrhoeae(NG),Chlamydia trachomatis(CT),Trichomonas vaginalis(TV), syphilis (lifetime contact) andMycoplasma genitalium(MG). Weighted HIV and other STIs prevalence and 95% CIs were calculated. Weighted multivariate logistic regression was performed to identify factors associated with having at least one STI (including HIV).ResultsBetween October 2017 and July 2018, 385 FSW participants were recruited, among whom 206 (53.5%) were IFSW and 179 (46.5%) were OFSW. The mean age was 31.4 years. Weighted HIV prevalence was 3.1% (95% CI 1.5 to 7.0). Weighted prevalence of other STIs was: 4.1% (95% CI 2.2 to 8.0) for NG, 8.8% (95% CI 5.9 to 13.0) for CT, 12.7% (95% CI 8.6 to 18.0) for TV, 13.9% (95% CI 9.9 to 19.0) for syphilis (lifetime contact) and 14.9% (95% CI 10.5 to 21.0) for MG. STI prevalence was significantly higher among OFSW for CT, TV and MG (p<0.001). In total, 43.2% of the participants had at least one HIV/STI. Factors associated with having HIV/STI were being an OFSW (OR 3.29; 95% CI 1.72 to 6.27); being registered in another Russian region (2.61 (95% CI 1.05 to 6.48)); having never been tested for HIV (2.51 (95% CI 0.98 to 6.41)) and having a low level of knowledge regarding HIV transmission (4.88 (95% CI 0.96 to 24.78)).ConclusionPrevalence of HIV and STIs was high among FSW in Moscow. OFSW were more vulnerable to STIs. There is an urgent need to tailor programmes for sexual and reproductive health for FSW in Russia.