bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron oxide nanocatalyst with titanium and silver nanoparticles: Synthesis, characterization and photocatalytic activity on the degradation of Rhodamine B dye
Authors: Muraro Pâmela Cristine Ladwig , Mortari Sérgio Roberto , Vizzotto Bruno Stefanello , Chuy Gabriela , dos Santos Cristiane , Brum Luís Fernando Wentz , da Silva William Leonardo 
Published: February 2020

AbstractNowadays, there is a growing concern about the environmental impacts of colored wastewater. Thus, the present work aims the synthesis, characterization and determination of photocatalytic activity of iron oxide (Fe2O3) nanocatalyst, evaluating the effect of hybridization with titanium (TiNPs-Fe2O3) and silver (AgNPs-Fe2O3) nanoparticles, on the degradation of Rhodamine B dye (RhB). Nanocatalysts were characterized by XRD, SEM, TEM, FTIR, N2 porosimetry (BET/BJH method), zeta potential and DRS. Photocatalytic tests were performed in a slurry reactor, with the nanocatalyst in suspension, using RhB as a target molecule, under ultraviolet (UV) and visible radiation. Therefore, the photocatalytic activity of the nanocatalysts (non-doped and hybridized) was evaluated in these ideal conditions, where the AgNPs-Fe2O3 sample showed the best photocatalytic activity with a degradation of 94.1% (k = 0.0222  min−1, under UV) and 58.36% (k = 0.007  min−1, under visible), while under the same conditions, the TiO2-P25 commercial catalyst showed a degradation of 61.5% (k = 0.0078  min−1) and 44.5% (k = 0.0044  min−1), respectively. According with the ideal conditions determined, reusability of the AgNPs-Fe2O3 nanocatalyst was measured, showing a short reduction (about 8%) of its photocatalytic activity after 5 cycles. Thus, the Fe2O3 nanocatalyst can be considered a promising catalyst in the heterogeneous photocatalysis for application in the degradation of organic dyes in aqueous solution.
Fusionsbildgebung – neue Entwicklungen in der interventionellen Kardiologie
Authors: Weber Marcel , Vogelhuber Johanna 
Published: February 2020

ZusammenfassungMit der Etablierung der kathetergestützten Aortenklappenimplantation rückte die multimodale Bildgebung mittels Fluoroskopie und Computertomografie immer mehr ins Augenmerk der interventionellen Kardiologie. Im Zuge der minimalinvasiven Möglichkeiten zur Therapie der Mitral- und Trikuspidalklappeninsuffizienz hat zusätzlich die interventionelle Echokardiografie an Bedeutung gewonnen. Zur weiteren Optimierung der kathetergestützten Herzklappentherapien können 2 dieser 3 Bildmodalitäten übereinander gelegt bzw. fusioniert werden, um dem Untersucher einen bestmöglichen Blick auf die jeweilige Herzklappe oder -struktur zu ermöglichen. Die unterschiedlichen Fusionslösungen könnten in Zukunft zu einer verbesserten periprozeduralen Sichtbarkeit führen und damit die Prozedurzeit verkürzen bzw. Kontrastmittel einsparen. Die hybride Fusionsbildgebung hat somit das Potenzial, die prozedurale Sicherheit sowie die Effektivität hinsichtlich der Device-Platzierung zu steigern. Diese Techniken sind jedoch derzeit noch im Erprobungsstadium und noch nicht in der klinischen Routine etabliert.
Videosprechstunden im berufsgenossenschaftlichen Heilverfahren – Anwendungsmöglichkeiten und ökonomische Evaluation
Authors: Fahlbusch Lisa , Achenbach Jannis , Hoffmann Felix R. 
Published: February 2020

Zusammenfassung
Ziel Videosprechstunden erlangen eine immer größere Bedeutung im Gesundheitswesen, da sie neue Behandlungskonzepte ermöglichen. Seit 2017 haben Videosprechstunden Einzug in die Regelversorgung der gesetzlichen Krankenversicherung gehalten, für das berufsgenossenschaftliche Heilverfahren fehlen bisher vergleichbare Angebote. Im Rahmen dieses Beitrags werden Anwendungsmöglichkeiten für eine Videosprechstunde im berufsgenossenschaftlichen Heilverfahren erörtert und eine ökonomische Bewertung vorgenommen.
Methodik Auf der Grundlage einer erfahrungsgestützten Analyse werden potentielle Anwendungsmöglichkeiten einer Videosprechstunde im berufsgenossenschaftlichen Heilverfahren erörtert. Die jeweiligen Leistungsinhalte wurden mit existierenden Gebührenordnungsziffern der UV-GOÄ bewertet.
Ergebnisse Videosprechstunden bergen im berufsgenossenschaftlichen Heilverfahren nicht nur als Verlaufskontrolle ein Nutzenpotenzial, sondern auch als Erstkontakt zur Vorbereitung aufwändiger Untersuchungstermine und bei Fallkonferenzen. Wenngleich Videosprechstunden in der UV-GoÄ bisher noch nicht abgebildet werden, existieren doch inhaltlich vergleichbare Abrechnungsziffern für andere Leistungen.
Schlussfolgerung Videosprechstunden bieten das Potenzial, sowohl die Qualität des berufsgenossenschaftlichen Heilverfahrens zu verbessern als auch zu einer Kostensenkung beizutragen. Da mit einer zunehmenden Bedeutung von Videosprechstunden zu rechnen ist, sollten Videosprechstunden als Regelleistung in das berufsgenossenschaftliche Heilverfahren aufgenommen und adäquate Abrechnungsmöglichkeiten erarbeitet werden.
Efficacy assessment of radiosynoviorthesis on the progression of radiological osteoarthritic features of hip and ankle joint in patients with osteoarthritis and rheumatoid arthritis
Authors: Szerb Imre , Gál Tamás , Kiss Dániel , Nagy Viktória , Hangody László 
Published: February 2020

Abstract
Objective The study objective was to evaluate the long-term effect of radiosynoviorthesis (RSO) on the progression of radiological and nuclear-medical osteoarthritic features of hip and ankle joint in patients with osteoarthritis and rheumatoid arthritis.
Patients and Methods The study included 89 hip joints of 81 patients, of which 48 had osteoarthritis (OA) and 33 had rheumatoid arthritis (RA). In terms of ankle joints, 64 patients were included of which 43 suffered from OA and 21 from RA. The mean follow-up time was 9.2 years for OA and 8.9 years for RA patients. Patients with RA were the active control group. Structural alterations of the hip joints were evaluated following Kellgren-Lawrence score and of ankle joint following Takakura score for both disease entities. For the evaluation of synovitis 2-phase bone scintigraphy was performed.
Results RSO could prevent radiologic status deterioration among 70.6 % of hip osteoarthritic patients and 73.7 % among the hip RA patients. No structural progression was observed in 79.1 % of the treated ankle joints in patients with OA and in 85.7 % of the ankle joints in patients with RA.The scintigraphic response rate for the hip joints of OA patients was 68.6 %, 76.3 % for hip joints of RA patients, 83.1 %, ankle joints of OA patients, and 90.4 % ankle joints of RA patients.The radiographic and scintigraphic RSO response rates were not significantly higher for both joints in RA than OA patients.
Conclusion RSO can be a good alternative in the treatment of synovitis and prevention of deterioration of inflammatory and radiographic features even in patients suffering from osteoarthritis and rheumatoid arthritis. RSO may have also a long-term effect to stop or delay progression of both diseases.
In Vivo Evaluation of Carvedilol Cardiac Protection Against Trastuzumab Cardiotoxicity
Authors: Beiranvand Elham , Ostad Seyed Nasser , Ardakani Esmat Mirabzadeh , Torkashvand Fatemeh , Sardari Soroush , Vaziri Behrouz 
Published: February 2020

AbstractCardiac dysfunction is a major side effect of trastuzumab therapy for patients with HER2-positive breast cancer. Beta blockers, such as carvedilol, have been used for protection of trastuzumab cardiotoxicity but there is no definitive conclusive clinical report on their efficacy. In the present study, the preservability effects of carvedilol on trastuzumab-induced left ventricular (LV) dysfunction and the reversibility of trastuzumab-induced cardiotoxicity were evaluated in Wistar rats by echocardiography method. We showed that trastuzumab treatment of rats could induce the LV dysfunction through increasing the LV internal systolic diameter (LVIDs), increasing the end-systolic volume (ESV), decreasing the ejection fraction (EF), and decreasing the fractional shortening (FS). These parameters were not reversed after 14 days of stopping trastuzumab administration. Interestingly, carvedilol improved LVIDs, ESV, EF, and FS. Collectively, the results of this study have verified clinical observations which simultaneously administration of carvedilol may be considered as a possible therapeutic strategy to prevent trastuzumab-mediated LV dysfunction.
Serum Irisin Concentrations in Severely Inflamed Patients
Authors: Buscemi Silvio , Corleo Davide , Vasto Sonya , Buscemi Carola , Barile Anna Maria , Rosafio Giuseppe , Randazzo Cristiana , Currenti Walter , Galvano Fabio 
Published: February 2020

AbstractIrisin is a recently discovered exercise-induced myokine that has been attributed the role of favoring white-to-brown adipose tissue trans-differentiation. We confirmed in a population-based cohort that irisin serum concentrations are independently correlated with the habitual level of physical activity, but we also observed an independent correlation with serum concentrations of high-sensitivity C-reactive protein (hs-CRP), thus suggesting that inflammation may influence irisin production. In order to investigate the association between irisin and inflammation, we measured serum irisin concentrations in a group of inflamed inpatients. We hypothesized that if an association between irisin and inflammation exists, severely inflamed patients, even though physically inactive, might also exhibit high serum irisin levels. We recruited 40 consecutive markedly inflamed inpatients on the basis of serum CRP levels. Their irisin serum concentrations (Phoenix Europe, Germany) were compared with those obtained in the population-based cohort of the ABCD_2 study (Alimentazione, Benessere Cardiovascolare e Diabete) (ISRCTN15840340). The inflamed patients exhibited higher serum irisin concentrations (median: 6.77 ng/ml; 95% CI for the median: 5.97–7.23) than those observed in the ABCD cohort (median: 5.21 ng/ml; 95% CI for the median: 5.08–5.30; p <0.001). Irisin concentrations were significantly correlated with age (r=−0.44; p <0.001), creatinine (r=−0.35; p <0.05), and fibrinogen (r=0.40; p <0.05) concentrations. No association was observed between irisin, interleukine-6 and tumor necrosis factor alpha. This study confirms the association between inflammation and irisin concentrations. Further studies are needed to understand the mechanisms underlying this association and its possible clinical implications.
Mycotic Abdominal Aortic and Iliac Aneurysm Caused by Streptococcus equi Subspecies zooepidemicus Bacteremia
Authors: Madani Anass , Zeebregts Clark J. , Lamprou Alexander , Tielliu Ignace F. J. 
Published: February 2020

AbstractThis report describes a case of a taxidermist who presented with sepsis and excruciating back pain a few weeks after contact with a deceased horse. Streptococcus equi subspecies zooepidemicus (SESZ) was isolated from patient’s blood and two isolated mycotic aneurysms were found. The first was located in the distal abdominal aorta and the second in the right common iliac artery. Treatment consisted of penicillin administration for 6 weeks and surgical debridement of the infected tissue combined with autologous vein reconstruction. The patient was infection-free without complaints 1 year after discharge and the venous reconstruction was patent. Reports in literature of bacteremia with SESZ leading to the development of mycotic aneurysms are very scarce and show that prognosis is generally unfavorable.
Navigation Improves the Survival Rate of Mobile-Bearing Total Knee Arthroplasty by Severe Preoperative Coronal Deformity: A Propensity Matched Case–Control Comparative Study
Authors: Jenny Jean-Yves , Saragaglia Dominique , Bercovy Michel , Cazenave Alain , Gaillard Thierry , Châtain Frédéric , Jolles-Haeberli Brigitte , Rouvillain Jean-Louis 
Published: February 2020

AbstractThe primary hypothesis of this study was that the survival rate over 10 years of total knee arthroplasties (TKAs) implanted with a navigation system was superior to that of TKAs implanted with a conventional technique. The secondary hypothesis was that the severity of the initial coronal deformity had a negative influence on the survival rate. A national, multicentric, retrospective study was performed in France, including eight university or private centers with high volumes in knee surgery. Cases operated on with either a conventional (control group) or a navigated (study group) technique were matched after calculating the propensity score using the logistic regression technique. All patients were contacted after 10 years or more to determine the survival of the TKA. The need for date and cause of revision were noted. The primary end point of the study was the occurrence of a revision for any mechanical reason. Survival curves were calculated using the Kaplan–Meier's technique, with the primary criterion as end point. The influence of the implantation technique was analyzed by a log-rank test at a 5% level of significance. The influence of severity of the preoperative coronal deformity was analyzed using the same technique. A total of 513 cases were included in each group. The survival rates after 13 years were 96.5% in the study group and 92.9% in the control group (not significant). There was no significant difference between both groups for the survival rates after 13 years for small deformity (96.0 vs. 97.0%), but the difference was significant for large deformity (97.0 vs. 89.0%, p = 0.04). The results suggest that the use of a navigation system, allowing a more consistent correction of the preoperative coronal deformity, thus allows a better long-term prosthetic survival in cases with a large initial coronal deformity. A navigation system should be routinely used in cases of initial coronal deformity greater than or equal to 10 degrees, as conventional techniques do not routinely provide satisfactory axial correction in these difficult cases.
Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice
Authors: Sugahara Go , Ishida Yuji , Sun Jeffrey , Tateno Chise , Saito Takeshi 
Published: February 2020

AbstractAdvancement in both bioengineering and cell biology of the liver led to the establishment of the first-generation humanized liver chimeric mouse (HLCM) model in 2001. The HLCM system was initially developed to satisfy the necessity for a convenient and physiologically representative small animal model for studies of hepatitis B virus and hepatitis C virus infection. Over the last two decades, the HLCM system has substantially evolved in quality, production capacity, and utility, thereby growing its versatility beyond the study of viral hepatitis. Hence, it has been increasingly employed for a variety of applications including, but not limited to, the investigation of drug metabolism and pharmacokinetics and stem cell biology. To date, more than a dozen distinctive HLCM systems have been established, and each model system has similarities as well as unique characteristics, which are often perplexing for end-users. Thus, this review aims to summarize the history, evolution, advantages, and pitfalls of each model system with the goal of providing comprehensive information that is necessary for researchers to implement the ideal HLCM system for their purposes. Furthermore, this review article summarizes the contribution of HLCM and its derivatives to our mechanistic understanding of various human liver diseases, its potential for novel applications, and its current limitations.
Association of Lumbar Degenerative Disease and Revision Rate following Total Knee Arthroplasty
Authors: Malahias Michael-Alexander , Gu Alex , Richardson Shawn S. , De Martino Ivan , Mayman David J. , Sculco Thomas P. , Sculco Peter K. 
Published: February 2020

AbstractRecently, a variety of studies have analyzed the potential correlation between lumbar degenerative disease (LDD) and inferior clinical outcomes after total hip arthroplasty. However, there has been limited data concerning the role of LDD as a risk factor for failure after total knee arthroplasty (TKA). The aim of our study was to determine: (1) what is the association of LDDs with TKA failure (all-cause revision) within 2 years of index arthroplasty and (2) if patients with LDD and lumbar fusion are at increased risk of TKA revision within 2 years compared with LDD patients without fusion. Data were collected from the Humana insurance database using the PearlDiver database from 2007 to 2017. To assess aim 1, patients were stratified into two groups based on a prior history of LDD (International Classification of Diseases [ICD]-9 or -10 diagnostic codes). To analyze aim 2, patients within the LDD cohort were stratified based on the presence of lumbar fusion (lumbar fusion Current Procedural Terminology code). All-cause revision rate was 3.4% among LDD patients versus 2.4% of patients with non-LDD (p < 0.001) at 2 years. Following multivariate analysis, LDD patients were at increased risk of all-cause revision surgery at 2 years (odds ratio [OR]: 1.361; 95% confidence interval [CI]: 1.238–1.498; p < 0.001) as well as aseptic loosening (OR: 1.533; 95% CI: 1.328–1.768; p < 0.001), periprosthetic joint infection (OR: 1.245; 95% CI: 1.129–1.373; p < 0.001), and periprosthetic fracture (OR: 1.521; 95% CI: 1.229–1.884; p < 0.001). Among LDD patients, patients who have a lumbar fusion had an all-cause revision rate of 5.0%, compared with 3.2% among LDD with no lumbar fusion patients at 2 years (p = 0.021). Following multivariate analysis, lumbar fusion patients were at increased risk of all-cause revision surgery (OR: 1.402; 95% CI: 1.362–1.445; p = 0.028), aseptic loosening (OR: 1.432; 95% CI: 1.376–1.489; p = 0.042), and periprosthetic fracture (OR: 1.302; 95% CI: 1.218–1.392; p = 0.037). Based on these findings, TKA candidates with preoperative LDD should be counseled that TKA outcome may be impaired by the coexistence of lumbar spine degenerative disease. This is Level III therapeutic study.
Changing Landscape of Dravet Syndrome Management: An Overview
Authors: Samanta Debopam 
Published: February 2020

AbstractDravet syndrome (DS), previously known as severe myoclonic epilepsy of infancy, is a severe developmental and epileptic encephalopathy caused by loss-of-function mutations in one copy of SCN1A (haploinsufficiency), located on chromosome 2q24, with decreased function of Nav1.1 sodium channels in GABAergic inhibitory interneurons. Pharmacoresistant seizures in DS start in the infancy in the form of hemiclonic febrile status epilepticus. Later, other intractable seizure types develop including myoclonic seizures. Early normal development in infancy evolves into moderate to severe intellectual impairment, motor impairment, behavioral abnormalities, and later a characteristic crouching gait. Clobazam, valproate, levetiracetam, topiramate, zonisamide, ketogenic diet, and vagus nerve stimulation had been shown to be effective, but even with polytherapy, only 10% of patients get adequate seizure control. The author provides a narrative review of the current treatment paradigm as well as recent advances in the management of DS based on a comprehensive literature review (MEDLINE using PubMed and OvidSP vendors with appropriate keywords to incorporate recent evidence), personal practice, and experience. In recent years, the treatment paradigm of DS is changing with the approval of pharmaceutical-grade cannabidiol oil and stiripentol. Another novel antiepileptic drug (AED), fenfluramine, had also shown excellent efficacy in phase 3 studies of DS. However, these AEDs primarily control seizures without addressing the underlying pathogenesis and other important common comorbidities such as cognitive impairment, autistic behavior, neuropsychiatric abnormalities, and motor impairment including crouching gait. Several agents targeted for DS are in the developmental stage: TAK935, lorcaserin, clemizole, huperzine analog, ataluren, selective sodium channel modulators and activators, antisense oligonucleotide therapy, and adenoviral vector therapy. As DS is associated with a high risk of sudden unexpected death in epilepsy, seizure detection devices can be used in this population for testing and clinical validation of these devices.
Platelet Inhibition in Acute Coronary Syndrome and Percutaneous Coronary Intervention: Insights from the Past and Present
Authors: Gorog Diana A. , Geisler Tobias 
Published: February 2020

AbstractPlatelet activation and aggregation have a pivotal role in arterial thrombosis and in the pathogenesis of both acute coronary syndromes (ACS) and in the thrombotic complications that occur in patients undergoing percutaneous coronary intervention (PCI). The past 30 years has seen the progress from early trials of clopidogrel and glycoprotein IIb/IIIa inhibitors to the application of more potent P2Y12 inhibitors prasugrel and ticagrelor. Early enthusiasm for newer and more potent antiplatelet agents, which could reduce ischemic events, has led to the understanding of the importance of bleeding and a desire to individualize and optimize treatment. It has increasingly become apparent that the potency and duration of dual antiplatelet therapy (DAPT) has to reflect the balance between ischemic and bleeding risk. Recently, multiple strategies have been proposed to individualize DAPT intensity and duration to reduce the bleeding and ischemic risks. Strategies of de-escalation of DAPT intensity, as well as shorter (less than a year) or more prolonged (beyond a year) treatment have been proposed, as well as platelet function test and genotype guidance of P2Y12 inhibitor therapy. Herein, we provide an overview of the progress in the field of antiplatelet therapy for ACS and PCI over the years, showing the current directions of travel. Ongoing studies focusing on personalized antiplatelet treatment will hopefully yield further insight into ways of optimizing outcomes for the individual.
FINGERPRINT ANALYSIS OF ETHNIC FEMALE KUWAITIS
Authors: Kumar Arunachalam 
Published: February 2020

AbstractFingerprint patterns and palmar dermatoglyphics have, over the decades not only been of significant application in identity establishment in forensics, but also played an adjunct role in diagnosis and confirmation of quite a few medical afflictions and syndromes.Many data banks on fingerprint profiles covering gender and diverse populations, ethnic groups and occupations have been compiled and are readily available for application and analysis. Observations of oddities, peculiarities or exclusiveness in print patterns across peoples have led to the accumulation of reliable markers that aid diagnostics and in specific assignments based on sex, disease, inheritance (both genotype and phenotype) and in classifications.This paper presents observations on fingerprint patterns and their variations found in adult Kuwaiti females from the Middle-east. A total of 360 prints were collected and results were collated for analysis. The results show a distinct difference in pattern in this ethnic populace, an increased frequency in ulnar loops. This undertaking, to my knowledge, is the first ever to cover a native Arab, could form the nucleus for more such and larger scale studies.