bluuebunny/crossref_metadata_2025_split huggingface dataset:
A library at the touch of a finger-tip: an analysis of mobile library services at the University of the West Indies, Mona campus
Authors: Duncan Adrian St. Patrick 
Published: December 2020

Purpose
The purpose of this paper is to assess the state of mobile library services available for students’ information needs at the University of the West Indies, Mona Campus. In addition, this study will determine the extent to which mobile services has helped the Mona libraries to have greater reach to students.

Design/methodology/approach
Surveys and content analysis were used to collect data. A comparative content analysis was used to highlight the strides made in mobile library services in universities across the world vis-à-vis the current reality in the Caribbean, specifically Jamaica.

Findings
The findings identified that there is a proliferation of mobile and internet users among university and college students and they are heavily using their devices for the furtherance of their educational attainment. Additionally, the findings indicated that libraries in the academic realm can benefit greatly from allowing their content to be accessible through these mobile devices, as it would also help with greater usage. Furthermore, this service is guaranteed greater support the distance programmes offered by these universities.

Research limitations/implications
This study will focus on assessing the state of mobile library services offered at the University of the West Indies, Mona Jamaica. This study will also determine the extent to which mobile services can help libraries to have greater reach to students and provide best practices for academic libraries implementing mobile service offerings to clients. This study will not attest to the financial feasibility of academic institutions to start such a programme.

Practical implications
The research excavated that the University of the West Indies, Mona Campus, along with other academic libraries in the Caribbean are all not fully offering mobile library services to all their users. In addition, with the rise of technology and the proliferation of cell phones and other mobile devices, students (distance and onsite) expect a service that allows them greater access to the offerings of the university and their libraries.

Originality/value
This is the premier investigation of its kind into how the University of the West Indies Mona Campus has responded to the mobile library environment. The value of this research is in helping academic and university libraries in the Jamaica to identify the importance of leveraging the benefits of the dynamic technological era, allowing greater and wider reach through mobile library services proliferation and access to services. In addition, this study showed that academic libraries need to enhance services in a bid to provide greater support the teaching component of the university or college they serve.
Primary validation of climate strategy proactivity questionnaire scale measuring relationship of climate strategy proactivity with competitive advantage
Authors: Kant Nikhil 
Published: December 2020

PurposeThis study was conducted with the objective of conducting a primary validation of a newly developed climate strategy proactivity questionnaire (CSPQ) scale for evaluating the relationship of climate strategy proactivity displayed by Indian companies with competitive advantage which it intends to attain and sustain through sources of sustained competitive advantage.Design/methodology/approachResearch design includes an exploratory factor analysis, conducted with a diverse sample of stakeholders of Indian companies, resulting into four internally consistent factors. This was followed by a confirmatory factor analysis with strong model fit estimates which confirmed the initial factor structure and resulted into a new final CSPQ scale. The scale without substituting any existing scale facilitated testing of all but criterion validity.FindingsFindings mainly comprise the primary validation of the CSPQ scale as psychometrically strong confirming acceptability of all major fit indices.Research limitations/implicationsCSPQ scale designed in the context of Indian companies is expected to make corporations and managers more aware in developing countries to help them draw an extensively enhanced scope of proactive climate strategy while making efforts to attain and sustain competitive advantage. However, the self-reported information collected through a common survey questionnaire might be affected by self-bias. Further, cross-sectional data to validate a new non-substituting scale prevented the researcher from conducting criterion validity test.Originality/valueBasing the development and validation of the CSPQ scale on the data collected from diverse stakeholders of Indian companies in as diverse a country as India, the scale can demonstrate significant robustness and implicative potential. The scale, by virtue of possessing significant attributes, can add remarkable value to strategic management applicable under any major theoretical perspective. It can serve the requirements of the empirical research and competitive management practices simultaneously.
Cultivating a learning culture in the US Navy
Authors: Cavallaro Liz , Nault William J. 
Published: December 2020

Purpose
This paper aims to explore the cultivation of a learning culture in the US Navy (USN). The intent of preparing and sharing this research is to reveal the particular challenges of developing learning organization capability in national security organizations. This paper believes this effort will contribute to the evolution and establishment of learning organization models that are replicable across and adaptable to distinct industrial settings.

Design/methodology/approach
Several efforts were explored and assessed by applying relevant research in the learning organization literature to trends in current organizational practice within the USN.

Findings
Recent USN learning culture efforts align with the broader, multi-sector, global trend toward building learning organizations to develop people as a source of competitive advantage. This research reveals the trials of enabling learning organizations across large, hierarchical bureaucracies with substantial structural and cultural barriers. The myriad obstacles currently being addressed by the USN, both at an institutional level and at smaller organization and unit levels, can inform the development of learning cultures. In particular, this research highlights the need to align specific efforts to the appropriate level of the organization.

Originality/value
This paper contributes to the learning organization conversation by examining the associated challenges through a multi-level framework – top, middle and bottom.
Consumer value‐based edible insect market segmentation [edible insect market segmentation]
Authors: Legendre T.S. 
Published: December 2020

AbstractEdible insect food products have been launched and in the market since 2011. Since then the number of companies that produce edible insect food product has increased greatly. However, the guidance of how these firms should effectively target which consumer market is unclear. The goal of this study is to provide information about the US consumer market that could potentially increase edible insect food product sales. This study uses consumer value as a segmenting axle and provides the cluster analysis results. From this analysis, academics and industry practitioners can have better insights about edible insect food product consumer profiles.
Lactobacillus rhamnosus MP108: Toxicological evaluation
Authors: Zhang Bo , Lynch Barry , Zhao Jian , Guo Yu , Mak Alastair 
Published: December 2020

AbstractA lyophilized powder of Lactobacillus rhamnosus MP108, a strain isolated from infant feces, has been developed for potential as a probiotic. To assess safety, three genetic toxicity studies (Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assays) and one 90‐day oral rat toxicity study were conducted. Lactobacillus rhamnosus MP108 had no activity in the Ames assay, with or without metabolic activation, up to the highest dose tested (5000 µg/plate). Also, no evidence of genotoxicity was observed in the two in vivo genotoxicity assays up to the maximum dose tested of 5.6 g/kg body weight. Feeding of L. rhamnosus MP108 to SD rats at doses of 0, 0.25, 0.5, or 1.5 g/kg body weight/day had no statistically or biologically significant effects on any of the parameters measured. An evaluation of Lactobacillus spp. generally, and L. rhamnosus specifically, showed no indication of concern for translocation or pathogenicity. The results of the toxicology studies showed no indications for safety concerns.Practical ApplicationLactobacillus rhamnosus MP108 is a bacterium that shows potential as a probiotic. While this bacterium has been used in food and food production, a series of studies were conducted to provide further assurance that this particular strain of L. rhamnosus is safe.
Pre‐operative epidural analgesia in hip fracture patients ‐ A systematic review and meta‐analysis
Authors: Rubin Monika Afzali , Stark Nikolaj Francis , Hårsmar Simon Julius Chamli , Møller Ann Merete 
Published: December 2020

BackgroundHip fracture is a common, painful injury with increasing global incidence. Patients require optimal acute pain management. Systematic reviews have investigated the postoperative use of epidural analgesia and found that it may have advantages over systemic analgesia. It is of interest to determine whether pre‐operative use of epidural analgesia is also advantageous.We conducted a systematic review and meta‐analyses on the effect of epidural analgesia on pre‐operative pain management in hip fracture patients.MethodsWe included randomized controlled trials comparing pre‐operatively initiated epidural analgesia with any other method of analgesia, in adults aged ≥55 years scheduled for hip fracture surgery. The main outcome was pre‐operative pain at rest. Electronic searches of four medical databases were performed. Two authors independently screened for eligibility, extracted data, and assessed risk of bias. We conducted meta‐analyses and assessed the certainty of the evidence by Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsThree articles were included, with 179 randomized patients. All studies compared epidural analgesia with systemic analgesia, one additionally with 3‐in‐1‐block. Meta‐analyses of pre‐operative pain measurements resulted in a mean difference of −5.85 95% CI [−14.90; 3.19] on a 0‐100 Visual Analogue Scale with a p‐value of 0.17 and a very low certainty of evidence according to the GRADE rating.ConclusionsWe did not find a difference in pre‐operative pain at rest between epidural analgesia and any other method of pre‐operatively initiated analgesia. The studies were few, of low quality and the difference between the two interventions remains unknown.
Neural Perturbations Associated With Recurrent Binge Alcohol in Male and Female Rats
Authors: West Rebecca K. , Rodgers Shaefali P. , Leasure J. Leigh 
Published: December 2020

BackgroundBinge drinking, characterized by brief periods of high intoxication interspersed with periods of abstinence, appears to be particularly damaging to the brain. Binge drinking is increasing among American women, yet few preclinical studies have assessed sex differences in the neurobehavioral effects of binge alcohol.MethodsAdult Long–Evans rats were administered 4 g/kg ethanol (EtOH; or an isocaloric control dose) via intragastric gavage once‐weekly. Brains were collected after 3 or 8 binge doses, and immunohistochemistry for mature neurons (NeuN), microglia (Iba1), neurogenesis (DCX), and reactive astrogliosis (vimentin) performed. Stereology was used to quantify target cell populations in the hippocampus and medial prefrontal cortex (mPFC). In a separate cohort of animals, cognition (spatial navigation and reversal learning), affect (tickling‐evoked ultrasonic vocalizations), and task‐induced c‐fos activation were assessed after 3 or 8 binge doses.ResultsBlood EtOH concentration did not differ significantly between females (175 ± 3.6 mg/dl) and males (180 ± 3.7 mg/dl) and did not change significantly over time, indicating that tolerance did not develop. After 3 or 8 binge doses, the number of granule neurons in the hippocampal dentate gyrus of both sexes was significantly reduced in comparison with controls, although there was no binge effect on newly generated neurons. Moreover, 8 (but not 3) binge doses significantly increased the total number of microglia and the number of partially activated microglia in the hippocampus and mPFC in both sexes. There was no detectable reactive astrogliosis (vimentin) in either region at any timepoint. There was no effect of binge alcohol on behavior outcomes in either sex, but binged rats showed increased cellular activation in the mPFC following reversal learning.ConclusionsOur data indicate that recurrent binge alcohol results in similar neural damage and neuroimmune activation in alcohol‐vulnerable corticolimbic brain regions in males and females.
Epigenetic Clock Analysis in Children With Fetal Alcohol Spectrum Disorder
Authors: Okazaki Satoshi , Otsuka Ikuo , Shinko Yutaka , Horai Tadasu , Hirata Takashi , Yamaki Naruhisa , Sora Ichiro , Hishimoto Akitoyo 
Published: December 2020

BackgroundFetal alcohol spectrum disorder (FASD) is characterized by severe clinical impairment, considerable social burden, and high mortality and morbidity, which are due to various malformations, sepsis, and cancer. As >50% of deaths from FASD occur during the first year of life, we hypothesized that there is the acceleration of biological aging in FASD. Several recent studies have established genome‐wide DNA methylation (DNAm) profiles as “epigenetic clocks” that can estimate biological aging, and FASD has been associated with differential DNAm patterns. Therefore, we tested this hypothesis using epigenetic clocks.MethodsWe investigated 5 DNAm‐based measures of epigenetic age (HorvathAge, HannumAge, SkinBloodAge, PhenoAge, and GrimAge) and telomere length (DNAmTL) using 4 independent publicly available DNAm datasets; 2 datasets were derived from buccal epithelium, and the other 2 datasets were derived from peripheral blood.ResultsCompared with controls, children with FASD exhibited an acceleration of GrimAge in 1 buccal and 2 blood datasets. No significant difference was found in other DNAm ages and DNAmTL. Meta‐analyses showed a significant acceleration of GrimAge in the blood samples but not in the buccal samples.ConclusionsThis study provides novel evidence regarding accelerated epigenetic aging in children with FASD.
Effects of lipopolysaccharide on proliferation, migration and osteogenic differentiation of apical papilla cells from early and late stage of root development
Authors: Aguilar Panuroot , Mahanonda Rangsini , Sa‐Ard‐Iam Noppadol , Lertchirakarn Veera 
Published: December 2020

AbstractThe aim of this study was to investigate the effects of lipopolysaccharide on cell proliferation, migration and osteogenic differentiation of apical papilla cells from early and late stage of root development. After challenging with various lipopolysaccharide concentrations to apical papilla cells from both stages of root development for 168 h, cell proliferation and migration were investigated. Osteogenic differentiation was examined by Alizarin red staining, and gene expressions of bone/cementum or dentin‐related genes were examined by polymerase chain reaction. Lipopolysaccharide did not affect cell proliferation and migration in both groups. Lipopolysaccharide at 1 and 5 µg mL−1 increased Alizarin red staining in apical papilla cells from early‐stage but not the late‐stage cells. Bone sialoprotein (bone/cementum marker) gene expression increased in both early and late stage of root development at 5 µg mL−1. These results might explain bone/cementum generation in regenerative endodontic procedures.
Inferiority of arteriovenous grafts, in comparison to autogenous fistulas, is underestimated by standard survival measures alone
Authors: Thwaites Stephen E. , Holt Stephen G. , Yii Ming K. 
Published: December 2020

AbstractBackgroundIt has been argued that a prosthetic arteriovenous graft (AVG) is a reasonable alternative to an arteriovenous fistula (AVF) for dialysis. We aimed to compare the patency rates and requirements for the intervention of newly formed AVF and AVG.MethodsA retrospective analysis was undertaken of AVF and AVG formed between 1 January 2013 and 31 December 2015 at two tertiary referral centres and followed up until 31 December 2017. Outcome measures included successful use for dialysis, patency rates and the number of interventions required to maintain dialysis access per patient‐year (PPY).ResultsFour hundred and seventy AVF and 92 AVG were constructed. Of 470 AVF, 324 (68.9%) were used compared to 80 of 92 (87%) AVG. One year assisted primary patency of AVF was 75% (confidence interval 71–79%) compared to 47% (confidence interval 36–57%) for AVG. Secondary patency rates for AVF at 1, 2 and 3 years were 77%, 71% and 69%, respectively. At the same time points, secondary patency rates for AVG were 77%, 60% and 46%, respectively (log rank P = 0.034). AVG required 2.4 times the number of interventions PPY than AVF. Surgical thrombectomy of AVG was at a rate of 0.49 PPY compared with 0.042 PPY for AVF.ConclusionAVG have a substantially higher rate of thrombosis than AVF, evident from early in the life of the graft. AVF demonstrate superior patency rates to AVG throughout the life of the access, with far fewer interventions PPY than grafts.
Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
Authors: Feneberg Emily , Charles Philip D. , Finelli Mattéa J. , Scott Connor , Kessler Benedikt M. , Fischer Roman , Ansorge Olaf , Gray Elizabeth , Talbot Kevin , Turner Martin R. 
Published: December 2020

AbstractThe pathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of cytoplasmic inclusions, containing C‐terminal fragments of the protein TDP‐43. Here, we tested the hypothesis that highly sensitive mass spectrometry with parallel reaction monitoring (MS‐PRM) can generate a high‐resolution map of pathological TDP‐43 peptide ratios to form the basis for quantitation of abnormal C‐terminal TDP‐43 fragment enrichment. Human cortex and spinal cord, microscopically staged for the presence of p‐TDP‐43, p‐tau, alpha‐synuclein, and beta‐amyloid pathology, were biochemically fractionated and analyzed by immunoblot and MS for the detection of full‐length and truncated (disease‐specific) TDP‐43 peptides. This informed the synthesis of heavy isotope‐labeled peptides for absolute quantification of TDP‐43 by MS‐PRM across 16 ALS, 8 Parkinson’s, 8 Alzheimer’s disease, and 8 aged control cases. We confirmed by immunoblot the previously described enrichment of pathological C‐terminal fragments in ALS‐TDP urea fractions. Subsequent MS analysis resolved specific TDP‐43 N‐ and C‐terminal peptides, including a novel N‐terminal truncation site‐specific peptide. Absolute quantification of peptides by MS‐PRM showed an increased C:N‐terminal TDP‐43 peptide ratio in ALS‐TDP brain compared to normal and disease controls. A C:N‐terminal ratio >1.5 discriminated ALS from controls with a sensitivity of 100% (CI 79.6–100) and specificity of 100% (CI 68–100), and from Parkinson’s and Alzheimer’s disease with a sensitivity of 93% (CI 70–100) and specificity of 100% (CI 68–100). N‐terminal truncation site‐specific peptides were increased in ALS in line with C‐terminal fragment enrichment, but were also found in a proportion of Alzheimer cases with normal C:N‐terminal ratio but coexistent limbic TDP‐43 neuropathological changes. In conclusion this is a novel, sensitive, and specific method to quantify the enrichment of pathological TDP‐43 fragments in human brain, which could form the basis for an antibody‐free assay. Our methodology has the potential to help clarify if specific pathological TDP‐43 peptide signatures are associated with primary or secondary TDP‐43 proteinopathies.
Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion
Authors: Ishida Akiko , Igarashi Katsushi , Ruike Yutaro , Ishiwata Kazuki , Naito Kumiko , Kono Satomi , Deguchi Hanna , Fujimoto Masanori , Shiga Akina , Suzuki Sawako , Yoshida Tomohiko , Tanaka Tomoaki , Tatsuno Ichiro , Yokote Koutaro , Koide Hisashi 
Published: December 2020

AbstractContextMild autonomous cortisol secretion (ACS) is associated with an increased risk of vertebral fractures (VFx). However, the influence of this condition on bone turnover or its association with mild ACS is still controversial.ObjectiveThis study aimed to evaluate the impact of mild ACS on bone quality among patients living with the disease.Design and settingA retrospective study was conducted using data from 55 mild ACS and 12 nonfunctioning adrenal tumour (NFT) patients who visited Chiba University Hospital, Japan, from 2006 to 2018.Patients and main outcome measuresWe analysed clinical features and bone‐related factors, including bone mineral density (BMD) and VFx, performed blood tests to assess bone metabolism markers in patients with mild ACS and NFT, and assessed the associations between bone‐related markers and endocrinological parameters in patients with mild ACS.ResultsNo significant differences between mild ACS and NFT patients were observed with respect to the presence or absence of VFx and BMD. Urinary free cortisol (UFC) was higher in mild ACS patients with VFx than those without (p = .037). The T‐score and young adult mean (YAM) of the BMD of the femoral neck in mild ACS patients with a body mass index <25 were positively correlated with dehydroepiandrosterone sulphate levels (ρ: 0.42, p = .017; ρ: 0.40, p = .024, respectively). Pearson's correlation analysis showed that bone‐specific alkaline phosphatase was negatively correlated with UFC in the patients with mild ACS (ρ: −0.37, p = .026).ConclusionsThese results suggest that urinary free cortisol may be useful for predicting bone formation in mild ACS patients.