bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic granulomatous hypophysitis presenting with galactorrhea, headache, and nausea in a woman: a case report and review of the literature
Authors: Sharifi Guive , Mohajeri-Tehrani Mohammad Reza , Navabakhsh Behrouz , Larijani Bagher , Valeh Touraj 
Published: November 2019

Abstract
Background
Inflammation of the pituitary gland can occur in a variety of primary or secondary disorders. Idiopathic granulomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can closely mimic a pituitary adenoma clinicoradiologically. Most authorities agree on minimally invasive transsphenoidal surgery as the mainstay in diagnosis and treatment of this disorder. There is still some controversy regarding pure medical management of idiopathic granulomatous hypophysitis in the literature.

Case presentation
A 47-year-old Iranian woman of Azeri ethnicity with a history of benign breast cysts with a chief complaint of galactorrhea presented to our endocrinology clinic. Her past medical history was negative for any menstrual irregularities, hirsutism, visual complaints, diplopia, polyuria and polydipsia or seizures. She was taking 100 mcg of levothyroxine daily. Her familial history and physical examination were unremarkable. Her initial laboratory work-up revealed hyperprolactinemia (82.4 ng/mL) with otherwise normal pituitary axes. Brain magnetic resonance imaging showed a pituitary macroadenoma for which she was treated with 0.5 mg of cabergoline weekly. Although her serum prolactin level dropped to 1.7 ng/mL and her galactorrhea was resolved, she continued to complain of headaches and nausea. Repeated imaging showed no decrease in size of the macroadenoma. Therefore, she underwent transsphenoidal surgery of the macroadenoma which was reported as chronic granulomatous hypophysitis by expert pathologists. Tuberculosis, sarcoidosis, Wegener’s granulomatosis, Langerhans cell histiocytosis, and syphilis were ruled out by appropriate tests and she was diagnosed as having idiopathic granulomatous hypophysitis. Fortunately, her condition was not complicated by hypopituitarism and she was symptom free 9 months after transsphenoidal surgery.

Conclusions
Idiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9 months of follow-up.
Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
Authors: Henderson Michael X. , Sengupta Medha , Trojanowski John Q. , Lee Virginia M. Y. 
Published: November 2019

AbstractMutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). While the clinical presentation of LRRK2 mutation carriers is similar to that of idiopathic PD (iPD) patients, the neuropathology of LRRK2 PD is less clearly defined. Lewy bodies (LBs) composed of α-synuclein are a major feature of iPD, but are not present in all LRRK2 PD cases. There is some evidence that tau may act as a neuropathological substrate in LB-negative LRRK2 PD, but this has not been examined systematically. In the current study, we examined α-synuclein, tau, and amyloid β (Aβ) pathologies in 12 LRRK2 mutation carriers. We find that α-synuclein pathology is present in 63.6% of LRRK2 mutation carriers, but tau pathology can be found in 100% of carriers and is abundant in 91% of carriers. We further use an antibody which selectively binds Alzheimer’s disease (AD)-type tau and use quantitative analysis of tau pathology to demonstrate that AD tau is the prominent type of tau present in LRRK2 mutation carriers. Abundant Aβ pathology can also be found in LRRK2 mutation carriers and is consistent with comorbid AD pathology. Finally, we assessed the association of neuropathology with clinical features in LRRK2 mutation carriers and idiopathic individuals and find that LRRK2 PD shares clinical and pathological features of idiopathic PD. The prevalence of AD-type tau pathology in LRRK2 PD is an important consideration for understanding PD pathogenesis and refining clinical trial inclusion and progression criterion.
Detailed descriptions of the lower-middle Triassic and Permian formations using cores and gamma-rays from the EPS-1 exploration geothermal borehole (Soultz-sous-Forêts, Upper Rhine Graben, France)
Authors: Aichholzer C. , Duringer Ph. , Genter A. 
Published: November 2019

AbstractIn the 1950s, a petroleum well in Soultz-sous-Forêts (no 4589; Upper Rhine Graben, France) reached the Lettenkohle (Triassic) at 830 m depth. During the exploration phase at Soultz-sous-Forêts, the first enhanced geothermal system pilot project in the world, the well was core-deepened up to 2227 m into the granitic basement (then renamed EPS-1). The objectives of this deeper well were (i) to explore the granitic fractured reservoir and (ii) provide a precise geological characterization of the Soultz-sous-Forêts horst. This paper presents the first complete core analysis of the sedimentary formations observed in the EPS-1 cores (from the middle Muschelkalk to the Permian) in conjunction with the gamma-ray log description and field works. The detailed descriptions of the geological formations encountered in the well are presented with photo boards displaying the most characteristic facies of each formation, since the wells are rarely cored, especially in the Muschelkalk. This study also aims to describe the gamma-ray log to provide a strong baseline for future geothermal well exploration in this area (or old well reinterpretations). At this time, it is the only available reference for the complete section: Muschelkalk to Permian sedimentary formations.
Characterizing popularity dynamics of hot topics using micro-blogs spatio-temporal data
Authors: Wu Lianren , Li Jinjie , Qi Jiayin 
Published: November 2019

AbstractIn this paper, a quantitative temporal and spatial analysis of the dynamics of hot topics popularity in Micro-blogging system was provided. Firstly, the popularity time series of 1167 hot topics were counted and calculated by Excel. Secondly, based on MATLAB software,the popularity time series were clustered into six clusters by K-spectral centroid (K-SC) clustering algorithm. Thirdly, we analyzed temporal patterns and spatial patterns of popularity dynamics of topics by statistical methods. The results show that temporal popularity of micro-blogging topics is rapidly dying, and the distribution of popularity is subject to the power law form. In addition, most of the Micro-blogging topics are global topic. Our results can provide a literature reference for studying the influence of online hot topics and the evolution of public opinion.
Risk factor analysis of the decrease in gait speed among Japanese older outpatients with polypharmacy
Authors: Deguchi Masataka , Nishida Keigo , Enokiya Tomoyuki , Ooi Kazuya 
Published: November 2019

Abstract
Background
Both polypharmacy and frailty are critical issues faced by the elderly. The decrease in gait speed is an index of frailty, and it is generally associated with falls and fractures, which are risk factors requiring the need for support or long-term patient care. In this study, we assess the risk factors responsible for the decrease in gait speed in older outpatients with polypharmacy.

Methods
Thirty-one persons (13 men, 18 women) aged 65 years or above and regularly taking 5 or more internal medications participated in this study.

Results
Propensity score-adjusted multivariate logistic analysis showed that only number of medications was associated with the risk of decreasing gait speed (odds ratio: 16.00, 95% confidence interval:1.72–149.00, p value = 0.0149). A negative correlation was found between the number of medications and gait speed. In addition, the gait speed of the calcium channel blocker medication group was significantly slower than that of the non-medication group.

Conclusion
These results suggest that not only the number of medications but also the prescription contents is a risk factor for decrease in gait speed and may serve as indexes to identify patients at high risk of requiring support or long-term care.
A Literature Review of Painful Hashimoto Thyroiditis: 70 Published Cases in the Past 70 Years
Authors: Peng Carol Chiung-Hui , Huai-En Chang Rachel , Pennant Majorie , Huang Huei-Kai , Munir Kashif M 
Published: November 2019

Abstract
Painful Hashimoto thyroiditis (pHT) is a rare diagnosis, and optimal treatment remains unclear. To better characterize pHT, PubMed, Embase, Scopus, and Web of Science indexes were searched for case reports or case series reporting pHT, published between 1951 and February 2019. Seventy cases reported in 24 publications were identified. Female predominance (91.4%) and a median age of 39.00 years (interquartile range, 32.50-49.75 years) were observed. Among reported cases, 50.8% had known thyroid disease (including Hashimoto thyroiditis, Graves disease, and seronegative goiters), 83.3% had positive antithyroid peroxidase antibodies, and 71.2% had antithyroglobulin antibodies. Most cases did not have preceding upper respiratory tract symptoms or leukocytosis. Ultrasound features were consistent with Hashimoto thyroiditis. Thyroid function at initial presentation was hypothyroid (35.9%), euthyroid (28.1%), or thyrotoxic (35.9%). Cases evolved into hypothyroidism (55.3%) and euthyroidism (44.7%), whereas none became hyperthyroid after medical treatment. Thyroid size usually decreased after medical treatment. Most cases were empirically treated as subacute thyroiditis with corticosteroids, levothyroxine, or nonsteroidal anti-inflammatory drugs. However, no therapy provided sustained pain resolution. In subgroup analysis, low-dose oral prednisone (&lt;25 mg/d) and intrathyroidal corticosteroid injection showed more favorable outcomes. Total thyroidectomy yielded 100% sustained pain resolution. Diagnosis of pHT is based on clinical evidence of Hashimoto thyroiditis and recurrent thyroid pain after medical treatment. The reference standard of diagnosis is pathology. Total thyroidectomy or intrathyroidal glucocorticoid injection should be considered if low-dose oral prednisone fails to achieve pain control.
Thyroid diseases detection rate in screenings of the population of the Kherson region
Authors: Yaroshenko V. I. , Golunov A. I. 
Published: November 2019

In many regions of the world, regardless of the presence of iodine endemic, a steady increase in thyroid pathology has been recorded over the past three decades. Given the unfavorable environmental situation that is typical for most countries today, one can think that this trend will continue and problems of the state of the thyroid gland will take place among the most relevant and significant in modern clinical medicine.
A natural consequence of this is the growing interest of scientists and practitioners of endocrinologists in the issues of early diagnosis and monitoring, the etiology and epidemiology of thyroid diseases.
In this study, we assessed the state of the thyroid gland with the aim of epidemiological analysis of the frequency of various forms of goiter in 5423 people living in 18 districts of Kherson region.
Lessicografia e critica del testo:
Authors: Viel Riccardo 
Published: November 2019

Attraverso una serie di tre esempî lessicali tratti dal corpus lirico del trovatore Giraut de Borneil, attestato nella seconda metà del XII secolo, si mostrerà come il modulo lessicale del database TrobVers sia in grado di aiutare il filologo nelle operazioni di sintesi e di valo- rizzazione della varia lectio dei manoscritti. Tali casi esemplari aiuteranno a riflettere circa il rapporto tra l’applicazione dei nuovi strumenti informatici a tradizioni testuali ecdotica- mente complesse e il metodo filologico, cercando di dimostrare che l’interfaccia digitale può aiutare nel difficile compito di coniugare la restitutio textus in termini neo-lachmanniani con la valorizzazione dei rapporti orizzontali e le redazioni lessicalmente significative delle differenti famiglie di manoscritti.
Some lexical examples from Giraut de Borneil’s lyric corpus (2nd half of the twelfth century) will show how textual scholarship may benefit from the database TrobVers, especially in locating and assessing the manuscript variants. Some cases in point will help shed new light on the relationship between the application of humanities computing to complex instances of textual transmission and broad methodological issues in textual scholarship. The essay argues that the digital interface may help bridge the gap between the neo-Lachmannian recensio and the necessary consideration of contamination and other forms of lexical inno- vation in the various groups of MSS.
Digital Editing and Linguistic Analysis:
Authors: Ventura Simone 
Published: November 2019

Attraverso una serie di tre esempî lessicali tratti dal corpus lirico del trovatore Giraut de Borneil, attestato nella seconda metà del XII secolo, si mostrerà come il modulo lessicale del database TrobVers sia in grado di aiutare il filologo nelle operazioni di sintesi e di valo- rizzazione della varia lectio dei manoscritti. Tali casi esemplari aiuteranno a riflettere circa il rapporto tra l’applicazione dei nuovi strumenti informatici a tradizioni testuali ecdotica- mente complesse e il metodo filologico, cercando di dimostrare che l’interfaccia digitale può aiutare nel difficile compito di coniugare la restitutio textus in termini neo-lachmanniani con la valorizzazione dei rapporti orizzontali e le redazioni lessicalmente significative delle differenti famiglie di manoscritti.
Some lexical examples from Giraut de Borneil’s lyric corpus (2nd half of the twelfth century) will show how textual scholarship may benefit from the database TrobVers, especially in locating and assessing the manuscript variants. Some cases in point will help shed new light on the relationship between the application of humanities computing to complex instances of textual transmission and broad methodological issues in textual scholarship. The essay argues that the digital interface may help bridge the gap between the neo-Lachmannian recensio and the necessary consideration of contamination and other forms of lexical inno- vation in the various groups of MSS.
Assessing the Micro-Deval Test for Compacted Dense-Graded Asphalt
Authors: Bazuhair Rabeea W. , Easterling Jonathan , Cox Ben C. , Howard Isaac L. 
Published: November 2019

Abstract
In recent years, the asphalt industry has been increasingly evaluating mixture testing for a variety of purposes. This article assesses the Micro-Deval (MD) test for its ability to evaluate compacted dense-graded asphalt mixtures. Historically, the MD test has been used to evaluate durability characteristics of loose aggregates, so this investigation deviates from the equipment’s intended purpose. MD testing was performed in traditional manners (i.e., submerged in water), as well as absent water. The investigation benchmarked MD testing against Cantabro mass loss and the Illinois Flexibility Index Test with an emphasis on use of the protocols during mixture production. Four evaluation criteria were used for assessment (level of rationality of test results, equipment cost, noise during testing, and time to achieve test results). Results of this investigation were that the MD testing protocol was not optimally suited for assessing compacted dense-graded asphalt. Wet MD tests (traditional test manner) were highly variable and provided no appealing test outputs. Operationally, the MD test was one of the noisier tests evaluated; it required an intermediate amount of time to conduct a test but had the lowest equipment cost. With all factors considered, the other tests considered are believed to be more promising than the MD for assessing dense-graded asphalt.
Stress Concentration Factors for ASTM E8/E8M-16a Standard Round Specimens for Tension Testing
Authors: Kardak A. A. , Sinclair G. B. 
Published: November 2019

Abstract
Occasionally, round specimens for tension testing that comply with ASTM standards fail in one of the transition regions between gage and grip sections. This occurs because of the stress concentration present in transition regions. When this happens, it is possible to seek stress relief by increasing fillet radii in these regions. The objective of this note is to quantify the relief afforded by increasing radii. The approach adopted to this end is finite element analysis that is carefully verified. Stress concentration factors are thus accurately determined to three figures for all of the various types of standard round specimens in ASTM E8/E8M-16a, Standard Test Methods for Tension Testing of Metallic Materials.
Dynamic Recrystallization in Titanium Alloys: A Comprehensive Review
Authors: Chatterjee Ritam , Narayana Murty S. V. S. , Alankar Alankar 
Published: November 2019

Abstract
This article is an attempt at highlighting recent advances made for understanding and modeling the phenomenon of dynamic recrystallization (DRX) prevalent in titanium alloys. Research work in recent years has focused on providing a rigorous description of key factors that influence the DRX process such as the effect of grain size, stacking fault energy, and other microstructural descriptors, thermomechanical processing, etc. The key addition of this work to existing literature is a critical commentary of important experimental as well as modeling efforts in recent years related to observing DRX in hexagonal close-packed (hcp) metals. We have attempted to directly compare, with reference to experiments, the effects of process variables such as strain rate, temperature, and composition on the occurrence of DRX in titanium alloys. A comprehensive review has been made of the experiments that have been carried out specifically to observe DRX in titanium alloys. This can aid modeling and validation efforts to accurately capture different facets of DRX for titanium alloys and other hcp metals. A similar comparison of the drawbacks and insights obtained from applying various modeling strategies, viz., FEM-based, phenomenological, or grid-based numerical methods for various alloys can provide valuable insights to choose appropriate modeling schemes or develop novel techniques to predict aspects of DRX such as preferred nucleation sites and evolution of microstructure, including grain boundaries and primary and secondary phases.
Unraveling the Hexaploid Sweetpotato Inheritance Using Ultra-Dense Multilocus Mapping
Authors: Mollinari Marcelo , Olukolu Bode A , Pereira Guilherme da S , Khan Awais , Gemenet Dorcus , Yencho G Craig , Zeng Zhao-Bang 
Published: November 2019

AbstractThe hexaploid sweetpotato (Ipomoea batatas (L.) Lam., 2n = 6x = 90) is an important staple food crop worldwide and plays a vital role in alleviating famine in developing countries. Due to its high ploidy level, genetic studies in sweetpotato lag behind major diploid crops significantly. We built an ultra-dense multilocus integrated genetic map and characterized the inheritance system in a sweetpotato full-sib family using our newly developed software, MAPpoly. The resulting genetic map revealed 96.5% collinearity between I. batatas and its diploid relative I. trifida. We computed the genotypic probabilities across the whole genome for all individuals in the mapping population and inferred their complete hexaploid haplotypes. We provide evidence that most of the meiotic configurations (73.3%) were resolved in bivalents, although a small portion of multivalent signatures (15.7%), among other inconclusive configurations (11.0%), were also observed. Except for low levels of preferential pairing in linkage group 2, we observed a hexasomic inheritance mechanism in all linkage groups. We propose that the hexasomic-bivalent inheritance promotes stability to the allelic transmission in sweetpotato.
A NovelcisElement Achieves the Same Solution as an AncestralcisElement During Thiamine Starvation inCandida glabrata
Authors: Iosue Christine L , Gulotta Anthony P , Selhorst Kathleen B , Mody Alison C , Barbour Kristin M , Marcotte Meredith J , Bui Lilian N , Leone Sarah G , Lang Emma C , Hughes Genevieve H , Wykoff Dennis D 
Published: November 2019

AbstractRegulatory networks often converge on very similar cis sequences to drive transcriptional programs due to constraints on what transcription factors are present. To determine the role of constraint loss on cis element evolution, we examined the recent appearance of a thiamine starvation regulated promoter in Candida glabrata. This species lacks the ancestral transcription factor Thi2, but still has the transcription factor Pdc2, which regulates thiamine starvation genes, allowing us to determine the effect of constraint change on a new promoter. We identified two different cis elements in C. glabrata - one present in the evolutionarily recent gene called CgPMU3, and the other element present in the other thiamine (THI) regulated genes. Reciprocal swaps of the cis elements and incorporation of the S. cerevisiae Thi2 transcription factor-binding site into these promoters demonstrate that the two elements are functionally different from one another. Thus, this loss of an imposed constraint on promoter function has generated a novel cis sequence, suggesting that loss of trans constraints can generate a non-convergent pathway with the same output.
Використання різних способів розмноження береки лікарської за відновлення у свіжих дібровах Південно-Подільського лісостепу України
Authors: Shpak N. P. 
Published: November 2019

Відтворення лісових насаджень за участю цінних видів деревних порід на сучасному етапі розвитку суспільства є актуальним завданням лісового господарства. Берека лікарська (Sorbus torminalis (L.) Crantz) – аборигенний вид, занесений до Червоної книги України (2009). Природний супутник лісових ценозів Південно-Подільського Лісостепу України, поновлення якого досліджували протягом п'яти років у деревостанах усіх вікових категорій та на зрубах, де залишені репродуктивні особини виду. Для дослідження кількісних та якісних показників поновлення Sorbus torminalis закладено 60 тимчасових та 11 постійних пробних площ. Природне насіннєве розмноження Sorbus torminalis виявлено у свіжих дібровах Південного Поділля. Насіння зберігає життєздатність 1-2 роки. У природних дубово-грабових насадженнях плодоношення настає в 20-річному віці, масове плодоношення спостережено раз у 5 років. Насіннєве розмноження використано для отримання сіянців і саджанців з метою введення Sorbus torminalis у культури дуба звичайного. Кращі результати отримано завдяки осіннім висівам свіжовимитого насіння за умов дотримання відповідних технологій. Осінні висіви здійснено у другій декаді вересня. Такі висіви дають весною дружні сходи і рівень їх ґрунтової схожості знаходиться в межах 78 %, що є досить успішним результатом для виду. Вегетативне порослеве розмноження сприяє її відновленню у разі механічних пошкоджень. Вирішення проблеми розмноження та оздоровлення породи можливе за умови використання сучасних досягнень біотехнології, одним з яких є метод мікроклонального розмноження. Цей метод дає можливість у стислі терміни одержати масовий, генетично однорідний садивний матеріал з високими спадковими властивостями продуктивності та стійкості до збудників хвороб. Для введення в культуру in vitro були верхівкові бруньки, нарізані з однорічних пагонів маточних рослин. Підібрано стерилізатори, а також визначено відповідні концентрації поживного середовища та експозиції. Впровадження різних способів розмноження береки лікарської сприятиме відновленню насаджень з її участю, а також розширення ареалу виду, що зникає.