bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Eating Disorder Topics on Twitter: Machine Learning Approach
Authors: Zhou Sicheng , Zhao Yunpeng , Bian Jiang , Haynos Ann F , Zhang Rui 
Published: September 2020

Background
Eating disorders (EDs) are a group of mental illnesses that have an adverse effect on both mental and physical health. As social media platforms (eg, Twitter) have become an important data source for public health research, some studies have qualitatively explored the ways in which EDs are discussed on these platforms. Initial results suggest that such research offers a promising method for further understanding this group of diseases. Nevertheless, an efficient computational method is needed to further identify and analyze tweets relevant to EDs on a larger scale.

Objective
This study aims to develop and validate a machine learning–based classifier to identify tweets related to EDs and to explore factors (ie, topics) related to EDs using a topic modeling method.

Methods
We collected potential ED-relevant tweets using keywords from previous studies and annotated these tweets into different groups (ie, ED relevant vs irrelevant and then promotional information vs laypeople discussion). Several supervised machine learning methods, such as convolutional neural network (CNN), long short-term memory (LSTM), support vector machine, and naïve Bayes, were developed and evaluated using annotated data. We used the classifier with the best performance to identify ED-relevant tweets and applied a topic modeling method—Correlation Explanation (CorEx)—to analyze the content of the identified tweets. To validate these machine learning results, we also collected a cohort of ED-relevant tweets on the basis of manually curated rules.

Results
A total of 123,977 tweets were collected during the set period. We randomly annotated 2219 tweets for developing the machine learning classifiers. We developed a CNN-LSTM classifier to identify ED-relevant tweets published by laypeople in 2 steps: first relevant versus irrelevant (F1 score=0.89) and then promotional versus published by laypeople (F1 score=0.90). A total of 40,790 ED-relevant tweets were identified using the CNN-LSTM classifier. We also identified another set of tweets (ie, 17,632 ED-relevant and 83,557 ED-irrelevant tweets) posted by laypeople using manually specified rules. Using CorEx on all ED-relevant tweets, the topic model identified 162 topics. Overall, the coherence rate for topic modeling was 77.07% (1264/1640), indicating a high quality of the produced topics. The topics were further reviewed and analyzed by a domain expert.

Conclusions
A developed CNN-LSTM classifier could improve the efficiency of identifying ED-relevant tweets compared with the traditional manual-based method. The CorEx topic model was applied on the tweets identified by the machine learning–based classifier and the traditional manual approach separately. Highly overlapping topics were observed between the 2 cohorts of tweets. The produced topics were further reviewed by a domain expert. Some of the topics identified by the potential ED tweets may provide new avenues for understanding this serious set of disorders.
Factors Associated With Influential Health-Promoting Messages on Social Media: Content Analysis of Sina Weibo
Authors: Rao Qingmao , Zhang Zuyue , Lv Yalan , Zhao Yong , Bai Li , Hou Xiaorong 
Published: September 2020

Background
Social media is a powerful tool for the dissemination of health messages. However, few studies have focused on the factors that improve the influence of health messages on social media.

Objective
To explore the influence of goal-framing effects, information organizing, and the use of pictures or videos in health-promoting messages, we conducted a case study of Sina Weibo, a popular social media platform in China.

Methods
Literature review and expert discussion were used to determine the health themes of childhood obesity, smoking, and cancer. Web crawler technology was employed to capture data on health-promoting messages. We used the number of retweets, comments, and likes to evaluate the influence of a message. Statistical analysis was then conducted after manual coding. Specifically, binary logistic regression was used for the data analyses.

Results
We crawled 20,799 Sina Weibo messages and selected 389 health-promoting messages for this study. Results indicated that the use of gain-framed messages could improve the influence of messages regarding childhood obesity (P<.001), smoking (P=.03), and cancer (P<.001). Statistical expressions could improve the influence of messages about childhood obesity (P=.02), smoking (P=.002), and cancer (P<.001). However, the use of videos significantly improved the influence of health-promoting messages only for the smoking-related messages (P=.009).

Conclusions
The findings suggested that gain-framed messages and statistical expressions can be successful strategies to improve the influence of messages. Moreover, appropriate pictures and videos should be added as much as possible when generating health-promoting messages.
BeyondSilos, a Telehealth-Enhanced Integrated Care Model in the Domiciliary Setting for Older Patients: Observational Prospective Cohort Study for Effectiveness and Cost-Effectiveness Assessments
Authors: Piera-Jiménez Jordi , Daugbjerg Signe , Stafylas Panagiotis , Meyer Ingo , Müller Sonja , Lewis Leo , da Col Paolo , Folkvord Frans , Lupiáñez-Villanueva Francisco 
Published: September 2020

BackgroundInformation and communication technology may provide domiciliary care programs with continuity of care. However, evidence about the effectiveness and cost-effectiveness of information and communication technology in the context of integrated care models is relatively scarce.ObjectiveThe objective of our study was to provide evidence on the clinical effectiveness and cost-effectiveness of the BeyondSilos project for patients enrolled in the Badalona city pilot site in Spain.MethodsA quasi-experimental study was used to assess the cost-effectiveness of information and communication technology–enhanced integration of health and social care, including the third sector (intervention), compared to basic health and social care coordination (comparator). The study was conducted in Badalona between 2015 and 2016. Participants were followed for 8 months.ResultsThe study included 198 patients: 98 in the intervention group and 100 in the comparator group. The mean Barthel index remained unchanged in the intervention group (mean change 0.14, 95% CI –4.51 to 4.78; P=.95) but decreased in the comparator group (mean change –3.23, 95% CI –5.34 to –1.11; P=.003). Instrumental Activities of Daily Living significantly decreased in both groups: mean changes of –0.23 (95% CI –0.44 to –0.02; P=.03) and –0.33 (95% CI –0.46 to –0.20; P<.001) in the intervention and comparator groups, respectively. No differences were found in the Geriatric Depression Scale (intervention: mean change 0.28, 95% CI –0.44 to 1.01, P=.44; comparator: mean change –0.29, 95% CI –0.59 to 0.01, P=.06). The intervention showed cost-effectiveness (incremental cost-effectiveness ratio €6505.52, approximately US $7582).ConclusionsThe information and communication technology–enhanced integrated domiciliary care program was cost-effective. The beneficial effects of this approach strongly rely upon the commitment of the professional staff involved.Trial RegistrationClinicalTrials.gov NCT03111004; http://clinicaltrials.gov/ct2/show/ NCT03111004
Reality and some Factors Related to Treatment Adherence in HIV/AIDS Children at Outpatient Clinic, Vietnam National Children’s Hospital
Authors: Tran Thi Ngoc , Do Thien Hai , Tran Thi Duyen , Nguyen Le Chinh 
Published: September 2020

Purpose: To characterize the prevalence and factors associated with ARV adherence in HIV/AIDS-infected children at outpatient clinics, Vietnam National Children's Hospital.
Methods: A cross-sectional study was conducted at outpatient clinics, Vietnam National Children's Hospital in 2019.
Results: The study results showed that 63% of HIV/AIDS infected children adhered to treatment and 37% of them did not adhere to ARV. The study investigated the relevance of 11 factors and found 5 factors related to pediatric noncompliance, including a short treatment period of less than 1 year (OR: 17.1; 95% CI: 2,26-75,5 and p < 0,01); waiting time for taking drugs is too long (OR: 19.3; 95% CI: 7.9-50.9 and p < 0.01); main caregivers aged ≥ 50 (OR = 42.3; 95% CI from 17.9-120.1 and p < 0.01.
Conclusions: The prevalence of ARV adherence in HIV/AIDS-infected children was 63%. Counseling intervention models to improve drug treatment compliance should be concentrated on newly infected children, treatment duration less than 1 year and their primary caregivers over 50 years old.
Epidemiological and Clinical Features of Patients Suffering from Severe Pneumonia Caused by RSV in the Respiratory Center of the Viet Nam National Children's Hospital
Authors: Le Thi Hong Hanh , Hoang Thi Thu Hang , Nguyen Thi  Le , Hoang Phuong Thanh , Dang Mai Lien 
Published: September 2020

Background/Purpose: Pneumonia is a common respiratory and life-threatening disease in pediatrics. Virus is an important cause of pneumonia in children, of which Respiratory syncytial virus (RSV) is the most common cause. The aim of this research is to access the clinical, epidemiological features and risk factors of patients suffering from RSV severe pneumonia.
Methods: We studied 250 patients suffering from severe pneumonia caused by RSV from June 2019 to December 2019 in the Respiratory Center of the Vietnam National Children’s Hospital.
Results: In Respiratory Center of our hospital, 3472 hospitalizations caused by pneumonia occurred in the last 6 months in 2019; 7.2% of these caused by RSV severe pneumonia. Pneumonia caused by RSV occurred most in male (66,7%), the rate of male/female = 2/1. The mean age was 4,94 ± 6,04 months. The prevalence of RSV in age groups is, respectively, as follows: less than 3 months (21,3%), from 3 months to 6 months (23,4%), from 6 months to 12 months (27%), from 12 months to 24 months (19%), over 2 years (9,3%). The most common symptoms which were accounted for over 80% were rhinorrhea, cough, wheeze, tachypnea and chest recession. The rate of admission increased sharply in December with 25.1% of cases. All hospitalized patients had respiratory distress symptoms with the frequent changes in blood gas, accounting for 59.2% of hypercapnia. The mean of hospitalization was 6,2 ± 7,4 days.
Conclusion: the rate of RSV infection increased in the last 6 months in 2019. Most of patients who less than 1 year of age were admitted to hospital because of severe clinical symptoms and respiratory distress. Risk factors were related to the severity of RSV severe pneumonia were: premature, mal-nutrition, bronchopulmonary dysplasia.
Application of Biotechnology in Detection ATP7B Gene Mutation in Vietnamese Children with Wilson Disease and Screening Target Mutation for Their Family Members
Authors: Nguyen Mai Huong , Nguyen Pham Anh Hoa , Ngo Diem Ngoc 
Published: September 2020

Background/Purpose: Wilson’s disease (WD) is an autosomal recessive disorder of the copper metabolism, which is caused by a mutation in the copper-transporting P-type ATPase (ATP7B). The mechanism of this disease is the failure of hepatic excretion of copper to bile, and leads to copper deposits in the liver and other organs. The ATP7B gene is located on the long arm of chromosome 13 (13q14.3). This study aimed to investigate the gene mutation in the Vietnamese patients with WD, and make a asymptomatic diagnosis for their familial members.
Methods: Forty-three WD patients and their 67 siblings were identified as having ATP7B gene mutations. Genomic DNA was extracted from peripheral blood samples; 21 exons and exon-intron boundaries of the ATP7B gene were analyzed by direct sequencing.
Results: A total of 27 different mutations were detected in this study, which accounted for 96.8%. Of which, S105* was the most prevalent mutation, accounting for 37.1%. Following was the five other mutations, including I1148T (7.3%), IVS14-2A>G (6.6%), L1371P (6.0%), T850I and V176SfsX28 (5.3%). Among 47 genotypes, ratio of compound heterozygote was 62.8%. Most of the mutations in the study occurred in exon 2 (43.0%), exon 16 (9.9%), exon 8 (8.6%), exon 14 and intron 14 (6.6%). A total of 13 affected siblings were identified by target mutation on ATP7B gene which was identified in the proband. Among them, 5 cases were asymptomatic that would be treated soon to prevent clinical feature. This study also discoved 65 carriers in their family members.
Conclusion: The findings’ highest diagnostic importance for patients and their family members is in prognosis and the prevention of morbidity and mortality.
Subclinical Characteristics and Treatment Results of Shigella in Gastroeterology Department, Vietnam National Children’s Hospital 2019
Authors: Nguyen Hong Tu , Dang Thi Thuy Ha , Hoang Bich Ngoc , Nguyen Thi Luong 
Published: September 2020

Purpose: To describe some subclinical characteristics of Shigella dysentery in children of the Gastroenterology Department at the Vietnam National Children’s Hospital in 2019 and review the results of treatment in these patients.
Methods: A cross-sectional descriptive study was conducted on patients under 15 years of age admitted to the Gastroenterology Department at Vietnam National Children's Hospital.
Results: The CRP index increased to 81.8%, of which the increase was mainly in the S.sonnei group. The rate of the most common bacteria strain is S.sonnei accounting for 87.1%, followed by S.fexneri 11.8%, S.dysenteriae encountered a case of 1.1%. No cases of stool culture resulted in S.boydii. The cure rate with Ciprofloxacin is 89.5%. The recovery rate is quite high, 93.3%, the percentage of patients who are also significantly better at 6.7% and there is no case of treatment failure.
Conclusions: The number of leukocytes and CRP in the peripheral blood is increased in most cases. The main antibiotic used is Ciprofloxacin, the treatment effectiveness with Ciprofloxacin antibiotic is 89.5%, the cure rate is high and there is no case of treatment failure.
Current Situation of Treatment and Follow-up Re-examination of Children with Epilepsy at Vietnam National Children’s Hospital
Authors: Tran Thi Huyen , Cao Vu Hung , Tran Van Hoc , Nguyen Danh Ngon 
Published: September 2020

Purpose: To assess treatment compliance and follow-up appointment of children with epilepsy at the Vietnam National Children’s Hospital in 2019.
Method: A cross-sectional descriptive study was conducted on pediatric patients and primary caregivers came for examination and treatment at the Neurology Department, Vietnam National Children’s Hospital from January 2019 to December 2019.
Results: Mean age was 74.3 ± 45.1 (month age). The most common age group was the 2-6 year old group (40.5%), the lower rate was the 6-12 year old group (30.0%), and rest groups was the low rate. The male: female ratio is 1.43:1. Most of the main caregivers are parents (92.5%). Average treatment time was 20.4 ± 15.7 months, the rate of good adherence to treatment 43.5%, 31.5% of children had moderated adhering to treatment and 25.0% had poor adhering to treatment. Within 6 months, 40.5% of children re-examined on time. The reasons for not complying with on-time re-examination were mainly due to the caregiver's busy work or the child was busy at school (37.8%) and the distance from home to hospital (26.1%).
Conclusions: The percentage of patients who complied with treatment and re-examination was not high. Factors that were statistically significant for children's non-compliance were: health insurance level, age of onset, duration of treatment, and frequency of attacks following treatment.
Some Risk Factors for Hospital Infections at the ICU in the Vietnam National Children’s Hospital
Authors: Pham Thi Hue , Le Kien Ngai , Hoang Bich Ngoc 
Published: September 2020

Purpose: To identify some risk factors for hospital infections in the ICU, Vietnam National Children’s Hospital in 2018-2019.
Method: A prospective cohort study was conducted.
Results: Malnutrition grade II or higher, PRISM > 10, ≥ 3 invasive intervention, use of H2-receptor antagonists and intravenous feeding were risk factors for nosocomial infections. Endotracheal intubation, intubation for > 5 days, re-intubation, and aspiration of vomit were risk factors for nosocomial pneumonia. Intravenous exposure, 3 or more IV lines, and central venous catheterization were risk factors for sepsis. Gastrointestinal surgery, surgery time > 2 hours, postoperative drainage, drainage time > 5 days and no prophylactic antibiotics were risk factors for wound infection. Urinary retention and urinary flow > 3 days were risk factors for urinary tract infections.
Conclusion: Nosocomial infections with grade II or higher malnutrition and 3 invasive interventions, the use of H2-receptor resistance and intravenous nutrition associated with nosocomial infections. Pneumonia, urinary tract infections, and sepsis are high risk factors for nosocomial infections.
Oil Price Flux and Macroeconomy of Oil Exporters
Authors: Madiha Riaz  , Saeed-ur-Rahman  , Shahzad Mushtaq  , Aabeera Atta  
Published: September 2020

Oil is an important energy source, embodies the largest commodity market in the world. Global economic performance has been highly correlated with oil price changes. The study considered 10 major oil exporters to measure the effect of oil price changes on their economies considering variables: Oil Prices (OP), Inflation (CPI) , GDP deflator, Lending interest rate (IR), real interest rate (RIR), Official Exchange Rate (EX), and Net domestic credit (LDU). By applying Johansen Co-integration techniques, long run relationship among variables has been analyzed covering the time period from 1970 to 2019. In order to find the short run relationship, Error Correction Model (ECM) technique is used. Study affirmed that there exist a strong relation among economic variables and oil price fluctuations; however the intensity of relationship displays a variation. Oil prices are associated with GDP deflator and RIR significantly as compared to other variables. Moreover, it can be suggested that each country should observe it own economic strategy in response to price change to reflect on economic policy instead of following some other country trends.
EVIDENCE OF HUMAN INTER-TISSUE BIOELECTROMAGNETIC TRANSFER: THE HUMAN BLOOD TISSUE INTRINSIC BIOELECTROMAGNETIC ENERGY TRANSFERRING ONTO A MINIORGAN
Authors: Embi Abraham A. 
Published: September 2020

Basically the human hair consists of a follicle a.k.a root penetrating the skin and an outer skin structure commonly called the shaft. The hair follicle has been classified as a miniorgan having its own cells divisions; aging stages and also demonstrated to emit electromagnetic radiation. The intent of this manuscript is to demonstrate via in vitro experiments evidence of human inter-tissue electromagnetic energy transfer through a glass slide, namely from human blood tissue to the previously described miniorgan or follicle.
The mechanism behind this new finding was possible due to the introduction in 2015 of a tabletop optical microscopy method designed to display plants and animal tissue electromagnetic energy emissions. Essential to present finding is the described property of anisotropic crystals of full absorption of incoming electromagnetic radiation waves. K3Fe is an anisotropic crystal. For example, a single layer human blood smear was sandwiched (SDW) by a second glass slide. On the top slide of the SDW, a freshly plucked in toto human hair was then covered by drops diluted K3Fe. Control experiments had repeatedly shown orderly semicircular periodic crystals of K3Fe triggered by the electromagnetic waves emitted by the hair follicle. Prior experiments by this author, have hinted at a “bioelectromagnetic cross-talk” between the follicle and blood. This was seen when there was physical contact between the follicle and blood drops on a glass slide. In the present experiments there is no direct tissue contact, the energy is transmitted through a 1 mm glass barrier. The data herein presented introduces Bioelectromagnetic Fields (BEMFs) energy from human blood onto a miniorgan. This energy is shown penetrating a 1 mm glass slide barrier. Further research is warranted to assess the physiological implications of the human blood tissue as a molecular and BEMFs energy source.
Actividad de la urticaria crónica espontánea en pacientes eutiroideos versus hipotiroideos
Authors: Herrera-Sánchez Diana Andrea , Álvarez Chávez Fabián Eduardo , O´Farrill-Romanillos Patricia María 
Published: September 2020

Antecedentes: La urticaria crónica afecta a 5 % de la población general y se asocia a enfermedad tiroidea hasta en 54 % de los pacientes. Existe escasa información de la actividad de la urticaria en los pacientes con y sin alteraciones de la función tiroidea.Objetivo: Comparar el índice de actividad de la urticaria con el UAS7 (Urticaria Activity Score 7) en pacientes con y sin hipotiroidismo.Métodos: Estudio descriptivo, transversal y comparativo de pacientes con urticaria crónica espontánea > 18 años, clasificados en dos grupos según su función tiroidea: con hipotiroidismo y eutiroideos. A todos se les aplicó el UAS7.Resultados: Se analizaron 60 pacientes con urticaria crónica espontánea, 30 eutiroideos y 30 hipotiroideos. Predominó el sexo femenino (76 %), la edad promedio fue de 49.1 años; 40 % tenía actividad moderada, 25 % grave, 23 % leve y 12 % estaba controlado. En el grupo con hipotiroidismo, la mediana de hormona estimulante de la tiroides fue de 6.8 μUI/mL. Entre los grupos no se encontraron diferencias estadísticamente significativas para la edad, índice de masa corporal y comorbilidades (hipertensión, diabetes o enfermedad alérgica) ni UAS7.Conclusiones: No encontramos diferencia estadísticamente significativa en el índice de actividad de la urticaria entre ambos grupos. Identificar qué factores permitirían mejorar la calidad de vida de los pacientes.
Reactividad a antígenos del microbioma de vías respiratorias en pacientes con enfermedad alérgica respiratoria
Authors: Trejo-Tapia Daniel , Henández-Ortega Martha Marcela , Valadez-Carmona Lourdes , Ochoa-Juárez Diana Berenice , Suárez-Souto María Antonieta , Trejo Gómez-Orozco Luis 
Published: September 2020

Antecedentes: La prevalencia de enfermedades alérgicas ha aumentado en todo el mundo. En estudios recientes se ha informado que la disbiosis de algunos miembros específicos de la microbiota humana puede potenciar la respuesta alérgica de las vías respiratorias.Objetivo: Explorar retrospectivamente el papel de algunos microorganismos de la microbiota humana en la reactividad cutánea y su efecto sobre la cronicidad de las enfermedades alérgicas respiratorias en el humano.Métodos: Análisis retrospectivo de la base de datos de un periodo de cinco años de pacientes con enfermedad alérgica de las vías respiratorias. Se determinó la frecuencia y magnitud de la reactividad a 38 alérgenos diferentes.Resultados: La mayor frecuencia de reactividad la presentó Dermatophagoides pteronyssinus (93.7 %), al que le siguió una combinación bacteriana de Staphylococcus aureus-Staphylococcus epidermidis (91.82 %) y Candida albicans (79.32 %). La reactividad a alérgenos de polen de malezas nativas de México fue aun menor, aproximadamente de 79 %.Conclusión: Los microorganismos de la microbiota analizados en este estudio parecen tener una influencia en el desarrollo de la inflamación alérgica respiratoria, asociada a la colonización a largo plazo de la faringe, la mucosa nasal y los senos.