bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dengue hemorrhagic fever as a rare cause of chronic immune thrombocytopenic purpura—a pediatric case report
Authors: Thadchanamoorthy V. , Dayasiri Kavinda 
Published: July 2020

AbstractBackgroundDengue is a common mosquito-borne infection in tropical countries. Dengue incidence in Sri Lanka is generally showing a rising trend. Both chronic immune thrombocytopenia purpura (ITP) children and chronic ITP triggered by dengue fever in the pediatric age group are rarely reported. This unusual presentation is a diagnostic challenge to clinicians. The authors have reported a pediatric patient who presented with chronic ITP following recovery from dengue hemorrhagic fever.Case presentationA 14-year-old previously healthy boy was initially managed as for dengue hemorrhagic fever. Following initial detection of persistent thrombocytopenia at 2 weeks post-discharge, his parents defaulted follow-up for 1 year as he remained asymptomatic. However, 1 year after initial admission, the child re-presented with ecchymotic patches and a platelet count of 30 × 103/cumm. Review of serial blood counts performed during previous hospital admission and by his parents themselves revealed persistent thrombocytopenia over preceding 12 months. Subsequently, the child had an in-depth evaluation. The diagnosis of ITP was confirmed by ruling out differential diagnosis and he was managed as for chronic ITP. His platelet counts showed good response to oral corticosteroids and he is currently being followed up at the pediatric hematology clinic.ConclusionWhile reporting, a 14-year-old boy who developed chronic ITP following dengue hemorrhagic fever, this report highlights importance of frequent monitoring of blood counts to accurately detect and manage critical phase of dengue fever. The report also highlights the value of monitoring platelet counts in post-recovery phase to ensure they have normalized.
Outcome measures of risk and recovery in Broadmoor High Secure Forensic Hospital: stratification of care pathways and moves to medium secure hospitals
Authors: McCullough Samantha , Stanley Carolyn , Smith Helen , Scott Molly , Karia Minesh , Ndubuisi Benignus , Ross Callum C. , Bates Rob , Davoren Mary 
Published: July 2020

Background
Placements within high secure forensic hospitals consist of wards providing various different levels of relational security. They should form a coherent pathway through secure care, based on individual patient risks and needs. Moves to less secure wards within high secure forensic hospitals and moves on to lower secure hospital settings have rarely been systematically studied.

Aims
The aim of this study was to ascertain if placements within Broadmoor High Secure Hospital and moves from Broadmoor to medium secure hospitals corresponded to measures of violence risk, programme completion and recovery.

Method
A 13-month prospective cohort study was completed. Patients (n = 142) were rated at baseline for violence risk (Historical, Clinical and Risk – 20), therapeutic programme completion and recovery (DUNDRUM tool) and overall functioning (Global Assessment of Functioning). Placements on the care pathway and moves on to medium secure hospitals were observed.

Results
Placements on the care pathway within the high secure hospital were associated with dynamic violence risk (F = 16.324, P<0.001), therapeutic programme completion (F = 4.167, P = 0.003), recovery (F = 2.440, P = 0.050) with better scores on these measures being found in the rehabilitation wards and the poorest scores on the highest levels of dependency. Moves to medium secure hospitals were associated with better scores on dynamic risk of violence (F = 33.199, P<0.001), therapeutic programme completion (F = 9.237 P<0.001), recovery (F = 6.863, P = 0.001).

Conclusions
Placements within Broadmoor Hospital formed a coherent pathway through high secure care. Moves to less secure places were influenced by more than reduction in violence risk. Therapeutic programme completion and recovery in a broad sense were also important.
Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT): A Phase Ib Dose-Escalation Study of Venetoclax Combined With Modified Intensive Chemotherapy
Authors: Chua Chong Chyn , Roberts Andrew W. , Reynolds John , Fong Chun Yew , Ting Stephen B. , Salmon Jessica M. , MacRaild Sarah , Ivey Adam , Tiong Ing Soo , Fleming Shaun , Brown Fiona C. , Loo Sun , Majewski Ian J. , Bohlander Stefan K. , Wei Andrew H. 
Published: July 2020

PURPOSE The B-cell lymphoma 2 (BCL-2) inhibitor venetoclax has an emerging role in acute myeloid leukemia (AML), with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients. The tolerability and efficacy of venetoclax in combination with intensive chemotherapy in AML is unknown. PATIENTS AND METHODS Patients with AML who were ≥ 65 years (≥ 60 years if monosomal karyotype) and fit for intensive chemotherapy were allocated to venetoclax dose-escalation cohorts (range, 50-600 mg). Venetoclax was administered orally for 14 days each cycle. During induction, a 7-day prephase/dose ramp-up (days −6 to 0) was followed by an additional 7 days of venetoclax combined with infusional cytarabine 100 mg/m2 on days 1-5 and idarubicin 12 mg/m2 intravenously on days 2-3 (ie, 5 + 2). Consolidation (4 cycles) included 14 days of venetoclax (days −6 to 7) combined with cytarabine (days 1-2) and idarubicin (day 1). Maintenance venetoclax was permitted (7 cycles). The primary objective was to assess the optimal dose schedule of venetoclax with 5 + 2. RESULTS Fifty-one patients with a median age of 72 years (range, 63-80 years) were included. The maximum tolerated dose was not reached with venetoclax 600 mg/day. The main grade ≥ 3 nonhematologic toxicities during induction were febrile neutropenia (55%) and sepsis (35%). In contrast to induction, platelet recovery was notably delayed during consolidation cycles. The overall response rate (complete remission [CR]/CR with incomplete count recovery) was 72%; it was 97% in de novo AML and was 43% in secondary AML. During the venetoclax prephase, marrow blast reductions (≥ 50%) were noted in NPM1-, IDH2-, and SRSF2-mutant AML. CONCLUSION Venetoclax combined with 5 + 2 induction chemotherapy was safe and tolerable in fit older patients with AML. Although the optimal postremission therapy remains to be determined, the high remission rate in de novo AML warrants additional investigation (ANZ Clinical Trial Registry No. ACTRN12616000445471).
Non-invasive evaluation for benign and malignant subcentimeter pulmonary ground-glass nodules (≤1 cm) based on CT texture analysis
Authors: Hu Xianghua , Ye Weichuan , Li Zhongxue , Chen Chunmiao , Cheng Shimiao , Lv Xiuling , Weng Wei , Li Jie , Weng Qiaoyou , Pang Peipei , Xu Min , Chen Minjiang , Ji Jiansong 
Published: July 2020

Objectives:
To investigate potential diagnostic model for predicting benign or malignant status of subcentimeter pulmonary ground-glass nodules (SPGGNs) (≤1 cm) based on CT texture analysis.

Methods:
A total of 89 SPGGNs from 89 patients were included; 51 patients were diagnosed with adenocarcinoma, and 38 were diagnosed with inflamed or infected benign SPGGNs. Analysis Kit software was used to manually delineate the volume of interest of lesions and extract a total of 396 quantitative texture parameters. The statistical analysis was performed using R software. The SPGGNs were randomly divided into a training set (n = 59) and a validation set (n = 30). All pre-normalized (Z-score) feature values were subjected to dimension reduction using the LASSO algorithm,and the most useful features in the training set were selected. The selected imaging features were then combined into a Rad-score, which was further assessed by ROC curve analysis in the training and validation sets.

Results:
Four characteristic parameters (ClusterShade_AllDirection_offset4_SD, ShortRunEmphasis_angle45_offset1, Maximum3DDiameter, SurfaceVolumeRatio) were further selected by LASSO (p &lt; 0.05). As a cluster of imaging biomarkers, the above four parameters were used to form the Rad-score. The AUC for differentiating between benign and malignant SPGGNs in the training set was 0.792 (95% CI: 0.671, 0.913), and the sensitivity and specificity were 86.10 and 65.20%, respectively. The AUC in the validation set was 72.9% (95% CI: 0.545, 0.913), and the sensitivity and specificity were 86.70 and 60%, respectively.

Conclusion:
The present diagnostic model based on the cluster of imaging biomarkers can preferably distinguish benign and malignant SPGGNs (≤1 cm).

Advances in knowledge:
Texture analysis based on CT images provide a new and credible technique for accurate identification of subcentimeter pulmonary ground-glass nodules.
Investigating a novel multiplex proteomics technology for detection of changes in serum protein concentrations that may correlate to tumor burden
Authors: Ren Annie He , Prassas Ioannis , Soosaipillai Antoninus , Jarvi Stephanie , Gallinger Steven , Kulasingam Vathany , Diamandis Eleftherios P. 
Published: July 2020

Background: To account for cancer heterogeneity, we previously introduced the concept of “personalized” tumor markers, which are biomarkers that are informative in subsets of patients or even a single patient. Recent developments in various multiplex protein technologies create excitement for the discovery of markers of tumor burden in individual patients, but the reliability of the technologies remains to be tested for this purpose. Here, we sought to explore the potential of a novel proteomics platform, which utilizes a multiplexed antibody microarray, to detect changes in serum protein concentration that may correlate to tumor burden in pancreatic cancer. Methods: We applied the Quantibody® Human Kiloplex Array to simultaneously measure 1,000 proteins in sera obtained pre- and post-surgically from five pancreatic cancer patients. We expected that proteins which decreased post-surgery may correlate to tumor burden. Sera from two healthy individuals, split into two aliquots each, were used as controls. To validate the multiplexed results, we used single-target ELISA assays to measure the proteins with the largest serum concentration changes after surgery in sera collected pre- and post-surgically from the previous five patients and 10 additional patients. Results: The multiplexed array revealed nine proteins with more than two-fold post-surgical decrease in at least two of five patients. However, validation using single ELISAs showed that only two proteins tested displayed more than two-fold post-surgical decrease in one of the five original patients. In the independent cohort, six of the proteins tested showed at least a two-fold decrease post-surgery in at least one patient. Conclusions: Our study found that the Quantibody® Human Kiloplex Array results could not be reliably replicated with individual ELISA assays and most hits would likely represent false positives if applied to biomarker discovery. These findings suggest that data from novel, high-throughput proteomic platforms need stringent validation to avoid false discoveries.
A protocol for the establishment and evaluation of an older adult stakeholder panel for health services research
Authors: Conneely Mairéad , Boland Pauline , O'Neill Aoife , Byrne David , Cronin Sinéad , Quinn Dominic , Trépel Dominic , Leahy Siobhán , Salsberg Jon , Galvin Rose , Robinson Katie 
Published: July 2020

Background: There has been a policy shift towards public and patient involvement (PPI) in population health and health services research in Ireland and internationally. Despite growing evidence that PPI can have positive impacts on the quality and appropriateness of health research, little is known about the involvement and impact of older adults as research partners. The aim of this study is to 1) describe the process of establishing a PPI panel of older adults, family carers and ageing research academics and 2) to evaluate the impact of this research partnership on all research partners. Methods: A partnership-focused framework will guide the recruitment and establishment of a PPI panel of older adults, family carers and academic researchers. Eight to ten older adults and four to six family carers with experience of using health services will be recruited through gatekeepers in a range of non-governmental, voluntary, and community organisations in the Mid-West region of Ireland. Academic researchers will be recruited through the Ageing Research Centre at the University of Limerick. To evaluating the impact of the research partnership on all members of the PPI panel we propose to record an activity log, maintain a record of all meeting, panel discussions and conduct individual interviews with all members of the research team at key time points. The final plan for evaluation will be negotiated and agreed with all members of the PPI panel. Data will be transcribed, managed in NVivo and analysed using an inductive approach to thematic analysis. Dissemination of research findings will be facilitated by the research partnership team of academics and older adults. Discussion: This study will identify learning about the process of establishing a PPI panel guided by a partnership-focused framework and will evaluate the impact of participation in a PPI panel for all members of the research team.
On-chip dispersive phase filters for optical processing of periodic signals
Authors: Kaushal Saket , Azaña José 
Published: July 2020

We develop a dispersive phase filter design framework suitable for compact integration using waveguide Bragg gratings (WBGs) in silicon. Our proposal is to utilize an equivalent “discrete” spectral phase filtering process, in which the original continuous quadratic spectral phase function of a group velocity dispersion (GVD) line is discretized and bounded in a modulo

2
π

basis. Through this strategy, we avoid the phase accumulation of the GVD line, leading to a significant reduction in device footprint (length) as compared to conventional GVD devices (e.g., using a linearly chirped WBG). The proposed design is validated through numerical simulations and proof-of-concept experiments. Specifically, using the proposed methodology, we demonstrate

2
×

pulse repetition-rate multiplication of a 10 GHz picosecond pulse train by dispersion-induced Talbot effect on a silicon chip.
Improving the width of lossy mode resonances in a reflection configuration D-shaped fiber by nanocoating laser ablation
Authors: Fuentes Omar , Vaiano Patrizio , del Villar Ignacio , Quero Giuseppe , Corres Jesús , Consales Marco , Matías Ignacio , Cusano Andrea 
Published: July 2020

The full width at half maximum (FWHM) of lossy mode resonances (LMRs) in the optical spectrum depends on the homogeneity of the thin film deposited. In this Letter, a method for improving the FWHM is applied for an LMR generated by a D-shaped optical fiber in reflection configuration. For this purpose, three samples with different attenuation were deposited with DC sputtering thin films of

S
n
O

2
−
x

, and a further controlled immersion of the samples in water was performed. A laser-cleaner method was used to improve the FWHM characteristics of one of the samples from 106 to 53 nm. This improvement can be applied to thin-film-based sensors where there is a problem with the inhomogeneity of the coating thickness. Moreover, with this technique, it was proved that a coated length of just 3–4 mm permits the generation of an LMR, with implications for the miniaturization of the final device.
Energy Optimization Using a Pump Scheduling Tool in Water Distribution Systems
Authors: Muhammed Karwan A. , Farmani Raziyeh 
Published: July 2020

Water distribution management system is a costly practice and with the growth of population, the needs for creating more cost-effective solutions are vital. This paper presents a tool for optimization of pump operation in water systems. The pump scheduling tool (PST) is a fully dynamic tool that can handle four different types of fixed speed pump schedule representations (on and off, time control, time-length control, and simple control [water levels in tanks]). The PST has been developed using Visual Basic programming language and has a linkage between the EPANET hydraulic solver with the GANetXL optimization algorithm. It has a user-friendly interface which allows the simulation of water systems based on (1) a hydraulic model (EPANET) input file, (2) an interactive interface which can be modified by the user, and (3) a pump operation schedule generated by the optimization algorithm. It also has the interface of dynamic results which automatically visualizes generated solutions. The capabilities of the PST have been demonstrated by application to two real case studies, Anytown water distribution system (WDS) and Richmond WDS as a real one in the United Kingdom. The results show that PST is able to generate high-quality practical solutions.
Bedeutung und Ausgestaltung von Robotic Process Automation (RPA) im Controlling
Authors: Knauer Thorsten , Nikiforow Nicole , Wagener Sebastian 
Published: July 2020

Im Rahmen dieser Studie wird mittels einer Befragung der Status quo des Einsatzes von Robotic Process Automation (RPA) und dessen Ausgestaltung im Controlling deutscher Unternehmen analysiert. Demnach wird RPA auch im Controlling zunehmend relevant, kommt aktuell mit einer Nutzungsrate von 8,31 % jedoch noch selten zum Einsatz. Gemäß der deskriptiven Auswertung zeigen sich bedeutsame Anwendungsfälle u. a. im Reporting und in der Kennzahlenermittlung. Die bestehenden Anwender sind dabei sowohl mit der Funktionserfüllung als auch der Geschwindigkeit der Aufgabenerfüllung sehr zufrieden.
Lipid-lowering therapy in patients with coronary artery disease in primary care practices: what has changed over 7 years?
Authors: Zyryanov S. K. , Fitilev S. B. , Vozzhaev A. V. , Shkrebneva I. I. , Klyuev D. A. , Stepanyan L. N. , Danilova A. A. , Tsai A. T. , Landyshev N. N. , Voronko Ya. G. 
Published: July 2020

Aim. To analyze changes in the pattern of lipid-lowering therapy (LLT) in outpatients with stable coronary artery disease (SCAD) over the 7-year period.Material and methods. This pharmacoepidemiological, retrospective, cross-sectional, two-stage study was conducted on the basis of primary care facility of Moscow. We analyzed 1,834 and 805 medical records of patients with SCAD at the first (2011) and second (2018) stages, respectively. Data on demography, medical history, lipid profile, and administrated LLT were collected. Statistical analysis was performed using SPSS Statistics V16.0 and MS Excel. Differences were considered significant at p<0,05.Results. Overall LLT prescription rate in outpatients with SCAD increased from 48,5 up to 86,4% (p<0,05) over the 7-year period. Statin monotherapy continued to prevail in the structure of LLT: its prescription rate increased from 48,2 up to 82,3% (p<0,05) in total sample. Use of statin/ezetimibe combination was registered only in 2018 (2,4% in LLT structure). Atorvastatin was the most frequently recommended medication at both study stages (51,5 vs 66,3%; p<0,05); prescription rate of simvastatin decreased from 44,5 to 3,9% (p<0,05), rosuvastatin — increased from 1,7 to 29,5% (p<0,05). Over the study period, the proportion of patients receiving high-intensity LLT increased (2,0 vs 41,8%; p<0,05). We also revealed a significant increase of patients who reached target levels of low-density lipoprotein cholesterol (11,1 vs 23,3%; p<0,05) and total cholesterol (17,0 vs 33,0%; p<0,05).Conclusion. The results demonstrated significant improvements in the LLT pattern over the 7-year period in outpatients with SCAD. Number of patients receiving statins doubled, and the cases of prescribing lowintensity LLT have become very rare. However, control of blood lipids in the target group remained inadequate.
KAJIAN ARSITEKTUR BERKELANJUTAN PADA BANGUNAN PUSAT PERBELANJAAN : MAL CILANDAK TOWN SQUARE
Authors: Mu'min Pandu Afdhalul 
Published: July 2020

Abstract: New shopping center facilities in urban areas are competing to be established by managers and investors to benefit from increasing demand for people’s daily needs today. However, the aspects that are applied to the building have not fully paid attention to sustainaible architecture factors, so that instead it has a negative impact on the surrounding environtment. Mall building was chosen because it is one of the examples of shopping facilities that are in demand by the community with quite rapid growth in every city, including the city of Jakarta as predicate metropolitan city and the capita of countryl today. The method used in this research is to use qualitative methods by collecting data, searching for literature, conducting observations in the field and analyzing sustainable architectural principles that have been applied to case studies. This research is expected to increase knowledge related to shopping center building standards and the application of sustainable architectural concepts that are appropriate threre in.Keywords: Sustainaible architecture, shopping center, qualitative method.Abstrak: Fasilitas pusat perbelanjaan baru di wilayah perkotaan berlomba – lomba didirikan oleh para pengelola dan investor untuk meraup keuntungan dari meningkatnya permintaan kebutuhan harian masyarakat nya saat ini. Akan tetapi, aspek – aspek yang diterapkan pada bangunan belum sepenuhnya memperhatikan faktor arsitektur berkelanjutan, sehingga malah menimbulkan dampak negatif pada lingkungan sekitarnya. Bangunan mal dipilih karena merupakan salah satu contoh fasilitas pusat perbelanjaan yang diminati oleh masyarakat dengan pertumbuhan yang cukup pesat di setiap kota, tak terkecuali kota Jakarta sebagai penyandang predikat kota metropolitan dan ibukota negara saat ini. Adapun dalam penelitian ini metode yang digunakan menggunakan metode kualitatif dengan melakukan pengumpulan data, mencari literatur, melakukan obvservasi ke lapangan dan menganalisis prinsip arsitektur berkelanjutan yang sudah diterapkan pada studi kasus. Dengan dilakukan nya penelitian ini diharapkan dapat meningkatkan pengetahuan terkait standar bangunan pusat perbelanjaan serta penerapan konsep arsitektur berkelanjutan yang sesuai didalamnya.Kata Kunci: Arsitektur berkelanjutan, pusat perbelanjaan, metode kualitatif.