bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Non-coding RNA NONSUST006715.1&nbsp;Suppresses Japanese Encephalitis Virus Proliferation in PK-15 Cells
Authors: Zhou Xiaolong , Yuan Qiongyu , Zhang Chen , Dai Zhenglie , Du Chengtao , Wang Han , Li Xiangchen , Yang Songbai , Zhao Ayong 
Published: September 2020

Abstract
Background: Japanese encephalitis virus is a mosquito-borne neurotropic flavivirus that causes acute viral encephalitis in humans. Pigs are crucial amplifier host of JEV. Recently, long non-coding RNAs have received increasing attention for their antiviral function. Methods: LncRNA-NONSUST006715.1 was overexpression or knockdown using western blotting and reverse-transcription polymerase chain reaction (RT-PCR) to detect the effect of lncRNA on JEV proliferation. CCR1 was found to regulate the expression of lncRNA-NONSUST006715.1 by inhibitors screen. Transcription factor SP1 was overexpression or knockdown using RT-PCR to detect the influence of SP1 on the expression of lncRNA. In addition, the enrichments of transcription factor SP1 on the promoter of lncRNA-NONSUST006715.1 were analyzed by Chromatin immunoprecipitation.Results: In this study, we demonstrated a new function of lncRNA-NONSUST006715.1, the inhibition of JEV proliferation in PK-15 cells. We found that C-C chemokine receptor type 1 inhibited the expression of lncRNA-NONSUST006715.1 via the transcription factor SP1. Knockdown of CCR1 could upregulated the expression of SP1 and lncRNA-NONSUST006715.1, resulting in resistance to JEV proliferation. Conclusions: These findings illustrate the importance of lncRNAs in virus proliferation, and reveal how this virus regulates lncRNAs in host cells to promote its proliferation.
Emergence of Unusual Rotavirus G9p[4] and G8p[8] Strains During Post Vaccination Surveillance in Argentina, 2017-2018&nbsp;
Authors: Degiuseppe Juan I , Stupka Juan A 
Published: September 2020

Abstract
Background. In 2015, Argentina included RotarixTM monovalent vaccine for universal administration and it showed a sharp decline in all-cause and rotavirus-confirmed cases as well as an immediate predominance of the G2P[4] genotype. The aim of this study was to analyze the impact of rotavirus vaccination on disease burden and genotype distribution in our country following its introduction. Methods. Prevalence and seasonality of laboratory-confirmed rotavirus cases data were assessed. Analyses of circulating genotypes were performed by conventional binary characterization (G and P typing). Phylogenetic study of VP7 gene was performed from emergent unusual strains. Results. During 2017-2018, 1183 rotavirus cases (13.2%) were detected and prevalence was uniform among different age subgroups. Weekly distribution showed a raise of confirmed cases around late July and early August. In 2017 the most frequently detected genotypes were G2P[4] and G3P[8]. However, in 2018 G12P[8] genotype increased and it was detected at a high rate. Noteworthy, the detection of uncommon G9P[4] and G8P[8] strains (bearing DS-1-like genetic backbones) was observed at moderate rates. Conclusions. Following four years of this strategy, the prevalence of rotavirus remained low in children under 5 years of age with a shift of the seasonal peak in early spring. The emergence of uncommon genotypes was due to introduction of new strains rather than to reassortment of local strains. Continuous monitoring of rotavirus burden of disease and genotype distribution provides useful evidence to evaluate existing immunization strategies and to contribute in the development of new vaccines as well.
Indirect comparison of 48-week efficacy and safety of long-acting cabotegravir and rilpivirine maintenance every 8 weeks with daily oral standard of care antiretroviral therapy in participants with virologically suppressed HIV-1-infection
Authors: Chounta Vasiliki , Snedecor Sonya J , Wu Sterling , Velde Nicolas Van de 
Published: September 2020

Abstract
BackgroundEfficacy and safety of long-acting cabotegravir (CAB) + rilpivirine (RPV) every 8 weeks (Q8W) versus daily oral standard of care (SoC) maintenance in treatment-experienced individuals with virologically suppressed human immunodeficiency virus type 1 (HIV-1) has not been directly compared in randomized clinical trials. This analysis aimed to indirectly compare these regimens. MethodsAn adjusted indirect treatment comparison of CAB + RPV Q8W with daily oral SoC was performed, using Phase 3 data from studies of CAB + RPV every 4 weeks vs SoC (Q4W; ATLAS/FLAIR, n=591 per group) and a Phase 3b trial of CAB + RPV Q8W vs Q4W (ATLAS-2M [excluding participants with prior CAB + RPV exposure]; n=327 per group). Eligible participants were virologically suppressed (viral load <50 HIV-1 ribonucleic acid (RNA) copies/mL), treatment-experienced individuals with HIV-1-infection. Treatment efficacy and safety at Week 48 included virologic suppression and lack of virologic suppression (proportion of participants with plasma HIV-1 RNA <50 copies/mL or ≥50 copies/mL, respectively; both as per FDA snapshot algorithm), CD4-cell count change from baseline, no virologic data, discontinuations due to adverse events (AEs), and overall AEs, serious AEs and Grade 3–5 AEs excluding injection-site reactions. Baseline characteristics between the Q4W arms of ATLAS/FLAIR and ATLAS-2M showed no significant differences or differences were not judged to be clinically relevant, apart from participants switching from a baseline third active drug class; more participants switched from integrase strand inhibitors in ATLAS/FLAIR, and from non-nucleoside reverse transcriptase inhibitors in ATLAS-2M. A subgroup analysis stratified by baseline third active drug class was performed. ResultsInjections of CAB + RPV Q8W showed no significant differences across efficacy and safety outcomes versus daily oral SoC. The subgroup analysis found there were no significant differences on virologic suppression or lack of virologic suppression for any baseline third active drug class subgroups. These results suggest that CAB + RPV Q8W is non-inferior to daily oral SoC.ConclusionsThis analysis supports the therapeutic potential of CAB + RPV Q8W for virologically suppressed people living with HIV-1 infection seeking an alternative maintenance treatment option to daily oral SoC.Trial registrationNCT02938520, NCT02951052, NCT03299049
Predictive Value of Clinical Toxicities to Chemotherapy&nbsp;with Fluoropyrimidines and Oxaliplatin in Colorectal Cancer by&nbsp;DPYD&nbsp;and GSTP1&nbsp;Genes Polymorphisms
Authors: Deng Xunwei , Hou Jingyuan , Deng Qiaoting , Zhong Zhixiong 
Published: September 2020

Abstract
Background: Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to Chemotherapy-related adverse events. The present study was aimed to determine the role of DPYD and GSTP1 variants on patient chemotherapy toxicity risk among the Hakka population, minimize adverse events and in order to maximize therapy outcome for individualized treatment.Methods: Genotyping was examined in 104 patients diagnosed with CRC cases and receiving fluoropyrimidine and platinum drugs based chemotherapy regimen by direct sequencing of DPYD and GSTP1 polymorphisms. Three DPYD variants including *2A, *5A, *9A and GSTP1 c.313A>G were analyzed and clinical outcomes were assessed. Results: The data suggest that the incidence of DPYD*5A, DPYD*9A and GSTP1 c.313A>G variants were 37.5%, 24% and 31.7%, respectively. DPYD*2A variant was not found. A total of 38 patients (36.5%) suffered severe neutropenia and 23 patients (22.1%) suffered severe vomiting. DPYD*5A polymorphism was found significantly associated with grade 3/4 ulceration (p = 0.001). GSTP1 was determined to be an independent risk factor for severe neutropenia and ulceration (p = 0.010 and p = 0.034, respectively). Patients with GSTP1 c.313A>G wild type contributed to higher risk for grade severe toxicity compared with A/G + G/G genotype (p = 0.024). However, there was no significant difference between patients with DPYD*9A T/T and T/C + C/C genotype for chemotherapeutic toxicity.Conclusions: The results demonstrated that DPYD*5A and GSTP1 polymorphisms were useful predictors for severe events. Screening of single nucleotide polymorphisms of DPYD and GSTP1 in colorectal cancer patients prior to chemotherapy may help to realize personalized therapy.
Solar-to-hydrogen peroxide energy conversion on resorcinol-formaldehyde resin photocatalysts prepared by acid-catalysed polycondensation
Authors: Shiraishi Yasuhiro , Hagi Takumi , Matsumoto Masako , Tanaka Shunsuke , Ichikawa Satoshi , Hirai Takayuki 
Published: September 2020

Abstract
The photocatalytic generation of hydrogen peroxide from water and dioxygen (H2O + 1/2O2 → H2O2, ΔG° = +117 kJ mol-1) under sunlight is a promising strategy for the artificial photosynthesis of a liquid fuel. We had previously found that resorcinol-formaldehyde (RF) resin powders prepared by the base-catalysed high-temperature hydrothermal method act as semiconductor photocatalysts for H2O2 generation. Herein, we report that RF resins prepared by the acid-catalysed high-temperature hydrothermal method (~523 K) using common acids at pH < 4 exhibit enhanced photocatalytic activity. The base- and acid-catalysed methods both produce methylene- and methine-bridged resins consisting of π-conjugated and π-stacked benzenoid-quinoid donor-acceptor resorcinol units. The acidic conditions result in the resins with a lower bandgap (1.7 eV) and higher conductivity because the lower degree of crosslinking creates a strongly π-stacked architecture. The irradiation of the RF-acid resins with simulated sunlight in water with atmospheric-pressure O2 generates H2O2 at a solar-to-chemical conversion efficiency of 0.7%, which is the highest efficiency ever reported for powder catalysts used in artificial photosynthesis.
Application of Ultrasound-Guided Intranodal Lymphangiography and Embolization in Cancer Patients With Postoperative Lymphatic Leakage
Authors: Sun Xingwei , Zhou Feng , Bai Xuming , Yuan Qiang , Zhang Mingqing , Ma Liang , Jin Yong 
Published: September 2020

Abstract
Background: Traumatic lymphatic leakage is a rare but potentially life-threatening complication. The purpose of this study was to introduce the technique of ultrasound-guided intranodal lymphangiography and embolization in the postoperative lymphatic leakage in patients with cancer.Methods: During January 2018 and June 2020, seven cancer patients (three males, four females, aged 59-75 years [mean 67.57 ± 6.11 years]) developed lymphatic leakage after abdominal or pelvic surgery, with drainage volume ranging from 550 to 1200 mL per day. The procedure and follow-up of ultrasound-guided intranodal lymphangiography and embolization were recorded. This study retrospectively analysed the technical success rate, operation time, hospital stay, clinical efficacy, and complications.Results：The operation was technically successful in all patients. Angiography revealed leakage and embolization was performed in all the seven patients (7/7, 100%). The operative time of angiography and embolization was 41 to 68 minutes, with an average time of 53.29 ± 10.27 minutes. The mean length of stay was 3.51±1.13 days. Lymph node embolization was finally clinically successful in five patients (5/7, 71.43%), with a significant reduction in or disappearance of chylous ascites. The other two patients received surgical treatment 2 weeks later due to poor results after embolization. All patients were followed-up for 2 weeks. No serious complications or only minor complications were found in all the patients.Conclusions：Ultrasound-guided intranodal lymphangiography and embolization are easy to tolerance, with a low incidence of complications. Early intervention is recommended for cancer patients with postoperative lymphatic leakage.
Application of the ACOSOG Z0011 Criteria to Chinese Patients with Breast Cancer: A Prospective Study
Authors: Peng Yuan , Liu Miao , Tong Fuzhong , Cao Yingming , Liu Peng , Zhou Bo , Liu Hongjun , Cheng Lin , Guo Jiajia , Xie Fei , Yang Houpu , Wang Siyuan , Wang Chaobin , Wang Shu 
Published: September 2020

Abstract
Background: Although the ACOSOG Z0011 study showed axillary lymph node dissection (ALND) could be avoided in a specific population of sentinel lymph node positive patients, it’s not widely accepted by Chinese surgeons. We conducted a prospective single-arm study to confirm whether or not the results of Z0011 are applicable to Chinese patients. Methods: Patients conforming to the Z0011 criteria were prospectively enrolled at the Peking University People’s Hospital Breast Center from November 2014 to June 2019. Clinicopathological features of the study group were compared with the Z0011 study. Lymphedema after surgery, incidence of local-regional recurrence, and survival were analyzed. Results: One hundred forty-two patients who met Z0011 eligibility criteria were enrolled in this study; 115 had sentinel lymph node biopsy (SLNB) alone. When comparing with the Z0011 trial, younger patients were included (median age, 52 [26- 82] years vs 54 [25-90] years; P = 0.03). Among clinical T stage, tumor histology, hormone status, lymphovascular invasion, and the number of positive sentinel lymph nodes (SLNs), no statistically significant differences were observed. More patients received adjuvant chemotherapy and endocrine therapy (90.85% vs 58.0% and 80.99% vs 46.6% respectively, P < .001). A similar percentage of patients received radiotherapy, but more nodal radiotherapy procedures were carried out in our study (54.5% vs 16.9%). After median follow-up of 29 months, only 1 patient (0.9%) had ipsilateral breast tumor recurrence and no regional recurrence occurred. Conclusion: Our study showed that it is achievable to avoid ALND in patients eligible for Z0011 in China. Trial registration: ClinicalTrials Registered Number: NCT03606616. Registered 31 July 2018-Retrospectiverly registered, https://www.clinicaltrials.gov/ct2/show/NCT03606616?term=Wang+shu&draw=4&ra nk=21.
Non-O Blood Group is Associated With a Higher Risk of Dyslipidaemia Amongst French Women
Authors: MacDonald Conor , Madika Anne-Laure , Severi Gianluca , Fournier Agnes , Boutron-Ruault Marie-Christine 
Published: September 2020

Abstract
IntroductionThe non-O blood groups have previously been associated with higher risk of cardiovascular disease in prospective cohort studies. While cross-sectional studies have identified higher serum cholesterol amongst A-group individuals, there is no evidence from prospective studies whether this translates into a higher risk of dyslipidaemia that requires treatment. This study aimed to prospectively determine potential associations between ABO blood groups and risk of incident dyslipidaemia requiring treatment.MethodsWe assessed associations between blood ABO group and dyslipidaemia in women participating in the E3N cohort. We included women who did not have cardiovascular disease at baseline. We used logistic regression to determine associations between ABO group and prevalent dyslipidaemia at baseline. Cox proportional hazard models were used to determine if blood ABO group was associated with an increased risk of incident dyslipidaemia, controlling for potential confounding.ResultsAt baseline, 55,512 women were included, and 10,058 incident cases of dyslipidaemia were identified at a rate of 17.6/1,000 PY. Of these participants, 24,510 reported being of the O-group, and 31,002 of non-O. Non-O blood groups were associated with prevalent dyslipidaemia (OR = 1.17 [1.13: 1.21]). The non-O blood groups were associated with an increased risk of dyslipidaemia (HR non-O = 1.14 [1.10: 1.19]), specifically the A group (HRA = 1.18 [1.13: 1.23]). Interactions with smoking were considered possible (p-interaction = 0.06), with AB smokers showing the highest risk of dyslipidaemia (HRAB smokers = 1.54 [1.12: 2.11]).ConclusionNon-O blood group, specifically the A group were associated with a moderately increased risk of dyslipidaemia.
A social media-based study on the psychological impact of COVID-19 infections in recovered and recovering patients
Authors: Kumar Vikesh , Varshney Mohit , Singh Harmandeep , Singh Amandeep , Baker Julien S. 
Published: September 2020

Abstract
AbstractObjective: The WHO has stressed to regularly monitor the mental health of populations during the COVID-19 pandemic. As a result, we conducted this study to examine anxiety and depression among recovered and recovering COVID-19 patients. Subjects and Methods: An online survey was conducted using a social media platform from 31/05/2020 to 24/06/2020. The study participants were COVID-19 infected individuals who had recovered or still were in the recovery phase from COVID-19. We collected information on demographics, clinical characteristics and physical complications of COVID-19. Anxiety and depressive symptoms were assessed using previously validated tools. Descriptive statistics and logistic regression were applied to analyze the data. Results: 53.4% of respondents reported that they had a fear of getting COVID-19 again. Anxiety and depressive symptoms were present in 71.7% and 97.6% of respondents respectively. Both disorders were present in 71.3% of respondents. The respondents with shorter durations of physical symptoms (< 2 weeks) demonstrated less anxiety (OR = 0.19; 95% CI: 0.05 - 0.67) and depression (OR = 0.03; 95% CI: 0.01 - 0.37). Conclusion: Anxiety and depression appear as common psychological complications in COVID-19 recovering and recovered patients. Longer durations of COVID-19 related physical symptoms were associated with an increased likelihood of anxiety and depression.
The Role Sol-gel Method and Doping Ba in the Drastic Reduction of the Annealing Time and the Improvement of the Coupling Between Grains of Bi1.6Pb0.4 Sr2-xBaxCa2Cu3Oy&nbsp;Superconductor&nbsp;
Authors: Ghahfarokhi seyed ebrahim Mousavi , Zamani Saeedeh 
Published: September 2020

Abstract
In this study, the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy superconductors with x = 0.0, 0.05, 0.1, 0.15, 0.2, 0.25, and 0.3 were synthesized at annealing times of 32, 48, 64 h using a sol-gel method. Then, the effect of Ba doped, the annealing times, ac magnetic fields and frequencies in the improvement of the coupling between grains of the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy (BPSBCC) superconductors were studied. In order to determine annealing temperature, TGA analysis of x = 0.0 was performed. The structural and ac magnetic susceptibility prepared samples were characterized using an X-ray diffraction, an ac susceptometer and scanning electron microscopy (SEM). The results of ac magnetic susceptibility and structural of the samples indicated that the improvement of the coupling between grains and the stability of the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy superconductors with value of x = 0.2 at 845 °C for 48 h have been increased.
Collaborative Involvement of Indigenous Youth in the Design and Evaluation of Digital Mental Health Interventions: A Scoping Review Protocol
Authors: Povey Josie , Raphiphatthana Buaphrao , Torok Michelle , Nagel Tricia , Shand Fiona , Sweet Michelle , Lowell Anne , Dingwall Kylie 
Published: September 2020

Abstract
Background: Indigenous youth worldwide are at greater risk of developing mental health concerns due to ongoing inequity and disadvantage. Digital mental health solutions are identified as a potential approach to improving access to mental health treatment for Indigenous youth, with evidence of acceptability and effectiveness beginning to emerge. Although collaborative design, development and evaluation is widely recognised as necessary to improving the acceptability of these tools, there is limited evidence to guide engagement of Indigenous youth in these processes. The objective of this scoping review is to map evidence regarding the collaborative involvement of Indigenous youth in the design and/or evaluation of digital mental health interventions. Methods: Scoping review methodology includes six stages, 1) identifying research question; 2) identifying relevant studies; 3) developing a study selection and data extraction method; 4) charting the data; 5) collating, summarising and reporting results. Additionally, Step 6) consultation, engages a male and female Indigenous health researcher in reviewing protocols, analysis and findings, enhancing credibility and ensuring findings are informed by Indigenous worldviews. Searches for relevant literature are undertaken in the following databases: EBSCOhost databases (Academic Search Premiere, Computer and Applied Science complete, CINAHL Plus with Full text, MEDLINE with full text, APA PsychArticles, Psychology and Behavioural Sciences collection, APA PsychInfo), PubMed, and Scopus. In addition, Infomit and Google (limited to the first 200 results) are searched for grey literature. All primary studies and grey literature in English that meet eligibility criteria are included. Data, including; study methods, methodologies, digital mental health program details, participant information and engagement and reporting processes are extracted and included for analysis. Data extraction variables are guided by the Consolidated Criteria for Strengthening Reporting of Health Research (CONSIDER statement). This statement provides a best practice checklist for reporting research involving Indigenous peoples. This scoping review protocol has been registered with Open Science Framework (available via osf.io/2nkc6).Discussion: To date, there are no reviews which critically analyse engagement of Indigenous youth in the development and evaluation of youth-specific digital mental health interventions. This review will aim to fill that gap and appraise alignment of current practice with best practice guidelines to inform future research. It will highlight appropriate strategies for the engagement of youth in collaborative processes, providing guidance for health practitioners, policy makers, and researchers working in the field of Indigenous youth and digital mental health.