bluuebunny/crossref_metadata_2025_split huggingface dataset:
Document analysis in health policy research: the READ approach
Authors: Dalglish Sarah L , Khalid Hina , McMahon Shannon A 
Published: May 2020

Abstract
Document analysis is one of the most commonly used and powerful methods in health policy research. While existing qualitative research manuals offer direction for conducting document analysis, there has been little specific discussion about how to use this method to understand and analyse health policy. Drawing on guidance from other disciplines and our own research experience, we present a systematic approach for document analysis in health policy research called the READ approach: (1) ready your materials, (2) extract data, (3) analyse data and (4) distil your findings. We provide practical advice on each step, with consideration of epistemological and theoretical issues such as the socially constructed nature of documents and their role in modern bureaucracies. We provide examples of document analysis from two case studies from our work in Pakistan and Niger in which documents provided critical insight and advanced empirical and theoretical understanding of a health policy issue. Coding tools for each case study are included as Supplementary Files to inspire and guide future research. These case studies illustrate the value of rigorous document analysis to understand policy content and processes and discourse around policy, in ways that are either not possible using other methods, or greatly enrich other methods such as in-depth interviews and observation. Given the central nature of documents to health policy research and importance of reading them critically, the READ approach provides practical guidance on gaining the most out of documents and ensuring rigour in document analysis.
How correlation risk in basket credit derivatives might be priced and managed?
Authors: Zhu Dong-Mei , Gu Jia-wen , Yu Feng-Hui , Ching Wai-Ki , Siu Tak-Kuen 
Published: May 2020

Abstract
In this paper, we construct quantitative models in which the dependence structure of the firms’ default times is incorporated. Such models serve as the underlying frameworks in our proposed approach to price and hedge basket credit derivatives. Through the Gaussian copula-based method, we model the default correlation risk and develop valuation formulas for credit derivatives. Using single-name derivatives in a hedging strategy for basket credit derivatives, the utility of the delta and delta-gamma hedging techniques are examined. This enables the management of risk attributed to the changes in correlation without the need for a large number of hedging instruments. Our research contributions provide insights on how dependent risks in basket credit derivatives could be dealt with effectively.
On BMO and Carleson Measures on Riemannian Manifolds
Authors: Brazke Denis , Schikorra Armin , Sire Yannick 
Published: May 2020

Abstract
Let $\mathcal{M}$ be a Riemannian $n$-manifold with a metric such that the manifold is Ahlfors regular. We also assume either non-negative Ricci curvature or the Ricci curvature is bounded from below together with a bound on the gradient of the heat kernel. We characterize BMO-functions $u: \mathcal{M} \to \mathbb{R}$ by a Carleson measure condition of their $\sigma $-harmonic extension $U: \mathcal{M} \times (0,\infty ) \to \mathbb{R}$. We make crucial use of a $T(b)$ theorem proved by Hofmann, Mitrea, Mitrea, and Morris. As an application, we show that the famous theorem of Coifman–Lions–Meyer–Semmes holds in this class of manifolds: Jacobians of $W^{1,n}$-maps from $\mathcal{M}$ to $\mathbb{R}^n$ can be estimated against BMO-functions, which now follows from the arguments for commutators recently proposed by Lenzmann and the 2nd-named author using only harmonic extensions, integration by parts, and trace space characterizations.
Hereditary and breastfeeding factors are positively associated with the aetiology of mammary gland hyperplasia: a case–control study
Authors: Gao Hanlu , Yang Chao , Fan Jinqing , Lan Li , Pang Da 
Published: May 2020

Abstract

Background
Hyperplasia of mammary gland (HMG) has become a common disorder in women. A family history of breast cancer and female reproductive factors may work together to increase the risk of HMG. However, this specific relationship has not been fully characterized.

Methods
A total of 1881 newly diagnosed HMG cases and 1900 controls were recruited from 2012 to 2017. Demographic characteristics including female reproductive factors and a family history of breast cancer were collected. A multi-analytic strategy combining unconditional logistic regression, multifactor dimensionality reduction (MDR) and crossover approaches were applied to systematically identify the interaction effect of family history of breast cancer and reproductive factors on HMG susceptibility.

Results
In MDR analysis, high-order interactions among higher-level education, shorter breastfeeding duration and family history of breast cancer were identified (odds ratio [OR] 7.07 [95% confidence interval {CI} 6.08 to 8.22]). Similarly, in crossover analysis, HMG risk increased significantly for those with higher-level education (OR 36.39 [95% CI 11.47 to 115.45]), shorter duration of breastfeeding (OR 27.70 [95% CI 3.73 to 205.70]) and a family history of breast cancer.

Conclusion
Higher-level education, shorter breastfeeding duration and a family history of breast cancer may synergistically increase the risk of HMG.
Evaluation of Synthetic Cannabinoid Metabolites in Human Blood in the Absence of Parent Compounds: A Stability Assessment
Authors: Krotulski Alex J , Bishop-Freeman Sandra C , Mohr Amanda L A , Logan Barry K 
Published: May 2020

Abstract
Synthetic cannabinoids represent a chemically diverse class of novel psychoactive substances (NPS) responsible for large analytical and interpretative challenges for forensic toxicologists. Between 2016 and 2019, the three most prevalent synthetic cannabinoids in the United States were MMB-FUBINACA (FUB-AMB), 5F-MDMB-PINACA (5F-ADB) and 5F-MDMB-PICA, based on results from seized drug and toxicology testing. In 2018, accurate determination of synthetic cannabinoid positivity was brought into question as it was determined that the metabolites of these drug species were present in the absence of parent compounds in forensically relevant blood samples. During this study, the stability of MMB-FUBINACA, 5F-MDMB-PINACA and 5F-MDMB-PICA was evaluated, as well as the characterization of breakdown products. A liquid–liquid extraction method was assessed for recovery of basic parent compounds and acidic metabolites and deemed fit for use in this study. Analysis was performed by liquid chromatography–quadrupole time-of-flight mass spectrometry (LC–QTOF-MS) using a SCIEX TripleTOF® 5600+. All three synthetic cannabinoids were found to be unstable when stored in blood at either room temperature or refrigerated; all analytes were considerably more stable when stored in the freezer. All three synthetic cannabinoids degraded to their respective butanoic acid metabolites: MMB-FUBINACA 3-methylbutanoic acid, 5F-MDMB-PINACA 3,3-dimethylbutanoic acid and 5F-MDMB-PICA 3,3-dimethylbutanoic acid. All three of these metabolites were studied and determined to be stable in blood at all storage conditions. Considering these results, our laboratory continued testing for synthetic cannabinoid metabolites in blood samples and found 83 positives (21%) for only a synthetic cannabinoid metabolite. A case report is presented herein where 5F-MDMB-PINACA 3,3-dimethylbutanoic acid was identified in the absence of 5F-MDMB-PINACA. Forensic toxicologists should be aware of the results of this study as they directly impact analytical consideration for test development and implementation, as well as interpretation of findings.
Behind the State: Domestic Mechanisms and Procedures for the Implementation of Human Rights Judgments and Decisions
Authors: Murray Rachel , De Vos Christian 
Published: May 2020

AbstractIt is the state to whom the supranational body directs its decision on a human rights violation, and it is the state who is found in violation and must provide the appropriate remedies. The state, however, is not a single entity: it is composed of the executive (and a web of different ministries and departments), the legislature, and the judiciary, including administrative bodies and tribunals. Depending on the type of reparations ordered, one, several, or all of these actors may be implicated. By tracking the mechanics of what happens in practical terms at the national level after decisions from UN treaty bodies and the regional human rights commissions and courts are adopted, findings from a three-year research project underscore that implementation is a multi-faceted process and whether implementation and ultimately compliance occurs can be explained, in part at least, by the regulatory, practical and technical processes in place to respond to those supranational decisions. By examining the role of these state actors and the procedures by which reparations are implemented and complied with at the national level, this article attempts to dissect the concept of ‘political will’. We conclude by providing some further thoughts on how litigators, states and supranational bodies themselves can adjust their methods accordingly.
Severity of emphysema as a prognosticator of resected early lung cancer: an analysis classified by Goddard score
Authors: Kagimoto Atsushi , Mimura Takeshi , Miyamoto Tatsuya , Nakashima Chika , Yamashita Yoshinori 
Published: May 2020

Abstract

Objectives
This study aimed to investigate whether the severity of emphysema as classified by Goddard score influences the prognosis of patients with early lung cancer, there are few reports about that.

Methods
From April 2009 to December 2016, we recruited 412 consecutive patients with completely resected clinical stage 0/IA/IB non-small cell lung cancer. The Goddard score assessed on preoperative computed tomography scan was retrospectively reviewed. Kaplan–Meier and Cox regression analyses were performed to assess the relationship between the Goddard score and early lung cancer prognosis.

Results
The patients were classified into two groups: Goddard score ≤ 4 points and ≥5 points according to the results of receiver operating characteristic curve analysis for recurrence events. The 3-year relapse-free survival rate of emphysema with Goddard score ≤ 4 points (88.6%) was higher than that of emphysema with Goddard score ≥ 5 points (60.8%) (P &lt; 0.001). There was a higher proportion of cancer-related deaths in the group with Goddard score ≥ 5 points compared with the group with Goddard score ≤ 4 points (50% and 32.1%, respectively) (P = 0.082). A Goddard score ≥ 5 points was a significant prognostic factor for relapse-free survival in the univariate (P &lt; 0.001) and multivariate (P = 0.022) analyses. A Goddard score ≥ 5 points was also a significant prognostic factor for overall survival in the univariate (P &lt; 0.001) and multivariate (P = 0.041) analyses.

Conclusion
Our findings suggest that emphysema with a Goddard score of ≥5 points may be a factor that can influence the prognosis of patients with primary lung cancer.
The ultraviolet colour component enhances the attractiveness of red flowers of a bee-pollinated plant
Authors: Chen Zhe , Liu Chang-Qiu , Sun Hang , Niu Yang 
Published: May 2020

AbstractAimsBee-pollinated flowers are rarely red, presumably because bees (which lack red receptors) have difficulty detecting red targets. Although the response of bees to red colour has been investigated in lab experiments, most stimuli have been pure red, while the subtle diversity of red as perceived by humans (human-red) has received very limited attention. Here we test the hypothesis that ultraviolet (UV) reflected from human-red flowers enhances their attractiveness to bees, through increased chromatic contrast.MethodsUsing Onosma confertum (Boraginaceae), a plant with UV-reflecting red flowers that are pollinated by bumblebees, we investigated the effects of UV reflection on pollinator responses by conducting phenotypic manipulation experiments in the field. Colour preferences of flower-naïve bumblebees were also examined. Colour perception by bumblebees was estimated in terms of chromatic and achromatic contrast, based on two different colour perception models.Important FindingsWe found that both natural and flower-naïve bumblebees strongly preferred visiting UV-reflecting targets compared with UV-absorbing ones. Colour models show that the UV-reflecting flowers exhibit higher spectral purity and higher chromatic contrast against the foliage background, whereas they have similar achromatic contrast in terms of green receptor contrast. These results indicate that the component of UV reflection increases chromatic contrast in O. confertum, enhancing the visual attractiveness of these red flowers to bumblebees. We further infer that the secondary reflectance might be a necessary component in human-red flowers that are primarily pollinated by animals without red receptors, such as bees.
Surgical creation of microphallus for cis-gender female desire for intersex condition
Authors: Salgado Christopher J , Lalama Maria , Navas Genesis 
Published: May 2020

Abstract
As the desire for an intersex phenotypic condition increases, surgeons need to become aware of the surgical possibilities there are realistic expectations and a sound mind. A 43-year-old married cis-gender female, on testosterone desired conversion of her enlarged clitoris into a micropenis or metoidioplasty without scrotoplasty or urethral lengthening to increase the size and accentuate her orgasmic response. Following clearance by mental health, a diamond perineoplasty and metoidioplasty using her labia minora was performed. At 1 year her Arizona Sexual Experience Scale increased and she was happy with the operation. Creation of a micropenis, in a cis-gender patient for an intersex state and heightened orgasmic response is surgically feasible.
CALCIUM-DEPENDENT PROTEIN KINASE 32-mediated phosphorylation is essential for the ammonium transport activity of AMT1;1 in Arabidopsis roots
Authors: Qin De-Bin , Liu Meng-Yuan , Yuan Lixing , Zhu Yun , Li Xi-Dong , Chen Li-Mei , Wang Yi , Chen Yi-Fang , Wu Wei-Hua , Wang Yang 
Published: May 2020

Abstract
Protein kinase-mediated phosphorylation modulates the absorption of many nutrients in plants. CALCIUM-DEPENDENT PROTEIN KINASES (CPKs) are key players in plant signaling to translate calcium signals into diverse physiological responses. However, the regulatory role of CPKs in ammonium uptake remains largely unknown. Here, using methylammonium (MeA) toxicity screening, CPK32 was identified as a positive regulator of ammonium uptake in roots. CPK32 specifically interacted with AMMONIUM TRANSPORTER 1;1 (AMT1;1) and phosphorylated AMT1;1 at the non-conserved serine residue Ser450 in the C-terminal domain. Functional analysis in Xenopus oocytes showed that co-expression of CPK32 and AMT1;1 significantly enhanced the AMT1;1-mediated inward ammonium currents. In transgenic plants, the phosphomimic variant AMT1;1S450E, but not the non-phosphorylatable variant AMT1;1S450A, fully complemented the MeA insensitivity and restored high-affinity 15NH4+ uptake in both amt1;1 and cpk32 mutants. Moreover, in the CPK32 knockout background, AMT1;1 lost its ammonium transport activity entirely. These results indicate that CPK32 is a crucial positive regulator of ammonium uptake in roots and the ammonium transport activity of AMT1;1 is dependent on CPK32-mediated phosphorylation.
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells
Authors: Kumar Janani , Kaur Gundeep , Ren Ren , Lu Yue , Lin Kevin , Li Jia , Huang Yun , Patel Anamika , Barton Michelle C , Macfarlan Todd , Zhang Xing , Cheng Xiaodong 
Published: May 2020

Abstract
Interactions of KRAB (Krüppel-associated box)-associated protein KAP1 [also known as TRIM28 (tripartite motif containing protein 28)] with DNA-binding KRAB zinc finger (KRAB-ZF) proteins silence many transposable elements during embryogenesis. However, in some cancers, TRIM28 is upregulated and interacts with different partners, many of which are transcription regulators such as EZH2 in MCF7 cells, to form abnormal repressive or activating complexes that lead to misregulation of genes. We ask whether a KRAB domain—the TRIM28 interaction domain present in native binding partners of TRIM28 that mediate repression of transposable elements—could be used as a tool molecule to disrupt aberrant TRIM28 complexes. Expression of KRAB domain containing fragments from a KRAB-ZF protein (ZFP568) in MCF7 cells, without the DNA-binding zinc fingers, inhibited TRIM28–EZH2 interactions and caused degradation of both TRIM28 and EZH2 proteins as well as other components of the EZH2-associated polycomb repressor 2 complex. In consequence, the product of EZH2 enzymatic activity, trimethylation of histone H3 lysine 27 level, was significantly reduced. The expression of a synthetic KRAB domain significantly inhibits the growth of breast cancer cells (MCF7) but has no effect on normal (immortalized) human mammary epithelial cells (MCF10a). Further, we found that TRIM28 is a positive regulator of TRIM24 protein levels, as observed previously in prostate cancer cells, and expression of the KRAB domain also lowered TRIM24 protein. Importantly, reduction of TRIM24 levels, by treatment with either the KRAB domain or a small-molecule degrader targeted to TRIM24, is accompanied by an elevated level of tumor suppressor p53. Taken together, this study reveals a novel mechanism for a TRIM28-associated protein stability network and establishes TRIM28 as a potential therapeutic target in cancers where TRIM28 is elevated. Finally, we discuss a potential mechanism of KRAB-ZF gene expression controlled by a regulatory feedback loop of TRIM28–KRAB.
Transition to Radial Approach for Neurovascular Procedures is Safe and Convenient: Characterization of a Learning Experience
Authors: Vergara-Garcia David , Gomez-Paz Santiago , Robinson Timothy M , Moore Justin , Ogilvy Christopher S , Thomas Ajith J 
Published: May 2020

Abstract

BACKGROUND
The transradial access for endovascular procedures has become a popular access point of preference for both patients and for many neuro-endovascular practitioners.

OBJECTIVE
To describe a single-center experience on the transition to a radial-first approach for neurovascular procedures, focused on diagnostic angiographies, and to compare the differences in terms of length of procedure within the first 5 mo of its execution.

METHODS
We performed a retrospective review of a prospective maintained cerebrovascular registry at an academic institution within the United States, to identify the expected adoption curve required to transition to a transradial route first approach focused mainly on diagnostic procedures. The 5 mo of experience were divided into 4 quartiles evenly distributed in time. The primary outcome was the total length of procedure. Secondary outcomes were access failure, radiation dose, the usefulness of ultrasound assistance and complications.

RESULTS
A total of 121 transradial procedures were performed: 113 diagnostic angiographies (93%) and 8 therapeutic interventions (7%). We identified 6 access failures (5%) and 1 complication (1%). The mean length for diagnostic angiographies was 24 ± 10 min, and for therapeutic procedures was 58 ± 19 min. A multivariate regression analysis demonstrated a significant decrease in the total length of procedures after the first quartile.

CONCLUSION
The transradial route shows to be a safe and convenient approach. The total length of procedure starts decreasing as providers gain experience and become more confident with this route, as seen in our 5-mo experience.
Prorogation: Comparative Context and Scope for Reform
Authors: Fleming Thomas G , Schleiter Petra 
Published: May 2020

Abstract
In August 2019, the UK government’s attempt to prorogue parliament for five weeks raised the question whether the UK’s prorogation rules ought to be reformed. We place this discussion in comparative perspective by contrasting the UK’s prorogation rules with (i) equivalent procedures in 26 European democracies and (ii) recent changes in other areas of UK executive–legislative relations. These comparisons suggest that the UK’s current prorogation rules are increasingly anomalous. They give governments significantly more power to suspend parliament than comparable European democracies, and are at variance with recent efforts to counterbalance the executive’s wide ranging discretion in the UK.
Brief Self-Compassion Training Alters Neural Responses to Evoked Pain for Chronic Low Back Pain: A Pilot Study
Authors: Berry Michael P , Lutz Jacqueline , Schuman-Olivier Zev , Germer Christopher , Pollak Susan , Edwards Robert R , Gardiner Paula , Desbordes Gaelle , Napadow Vitaly 
Published: May 2020

Abstract

Objective
Self-compassion meditation, which involves compassion toward the self in moments of suffering, shows promise for improving pain-related functioning, but its underlying mechanisms are unknown. This longitudinal, exploratory pilot study investigated the effects of a brief (eight contact hours, two weeks of home practice) self-compassion training on pain-related brain processing in chronic low back pain (cLBP).

Methods
We evaluated functional magnetic resonance imaging (fMRI) response to evoked pressure pain and its anticipation during a self-compassionate state and compared altered brain responses following training with changes on self-reported measures of self-compassion (Self-Compassion Scale [SCS]), interoceptive awareness (Multidimensional Assessment of Interoceptive Awareness [MAIA]), and clinical pain intensity.

Results
In a sample of participants with cLBP (N = 20 total, N = 14 with complete longitudinal data) who underwent self-compassion training, we observed reduced clinical pain intensity and disability (P &lt; 0.01) and increased trait self-compassion and interoceptive awareness (all P &lt; 0.05) following training. Evoked pressure pain response in the right temporo-parietal junction (TPJ) was reduced following training, and decreases were associated with reduced clinical pain intensity. Further, increased fMRI responses to pain anticipation were observed in the right dorsolateral prefrontal cortex (dlPFC) and ventral posterior cingulate cortex (vPCC), and these increases were associated with mean post-training changes in SCS scores and scores from the body listening subscale of the MAIA.

Discussion
These findings, though exploratory and lacking comparison with a control condition, suggest that self-compassion training supports regulation of pain through the involvement of self-referential (vPCC), salience-processing (TPJ), and emotion regulatory (dlPFC) brain areas. The results also suggest that self-compassion could be an important target in the psychotherapeutic treatment of cLBP, although further studies using controlled experimental designs are needed to determine the specificity of these effects.