bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of the cancer stem cell marker SSEA1 is associated with poor survival in metastatic high-grade serous carcinoma
Authors: Davidson Ben , Holth Arild , Dong Hiep Phuc 
Published: May 2020

AbstractThe objective of the present study was to perform a quantitative analysis of cancer stem cell (CSC) marker expression in ovarian carcinoma effusions. The clinical role of SSEA1 in metastatic high-grade serous carcinoma (HGSC) was additionally analyzed. CD133, Nanog, SOX2, Oct3/4, SSEA1, and SSEA4 protein expressions were quantitatively analyzed using flow cytometry (FCM) in 24 effusions. SSEA1 expression by immunohistochemistry was analyzed in 384 HGSC effusions. Highly variable expression of CSC markers by FCM was observed, ranging from 0 to 78% of Ber-EP4-positive cells in the case of CD133, with the largest number of negative specimens seen for SSEA4. SSEA1 expression by immunohistochemistry was found in HGSC cells in 336/384 (89%) effusions, most commonly focally (< 5% of cells). SSEA1 was overexpressed in post-chemotherapy disease recurrence specimens compared with chemo-naïve HGSC effusions tapped at diagnosis (p = 0.029). In univariate survival analysis, higher SSEA1 expression was significantly associated with poor overall survival (p = 0.047) and progression-free survival (p = 0.018), though it failed to retain its prognostic role in Cox multivariate survival analysis in which it was analyzed with clinical parameters (p = 0.059 andp = 0.111 for overall and progression-free survival, respectively). In conclusion, CSC markers are variably expressed in ovarian carcinoma effusions. SSEA1 expression is associated with disease progression and poor survival in metastatic HGSC. Silencing this molecule may have therapeutic relevance in this cancer.
Neonatal resuscitation guideline adherence: simulation study and framework for improvement
Authors: Binkhorst Mathijs , van de Wiel Irene , Draaisma Jos M. T. , van Heijst Arno F. J. , Antonius Tim , Hogeveen Marije 
Published: May 2020

AbstractWe wanted to assess newborn life support (NLS) knowledge and guideline adherence, and provide strategies to improve (neonatal) resuscitation guideline adherence. Pediatricians completed 17 multiple-choice questions (MCQ). They performed a simulated NLS scenario, using a high-fidelity manikin. The literature was systematically searched for publications regarding guideline adherence. Forty-six pediatricians participated: 45 completed the MCQ, 34 performed the scenario. Seventy-one percent (median, IQR 56–82) of the MCQ were answered correctly. Fifty-six percent performed inflation breaths ≤ 60 s, 24% delivered inflation breaths of 2–3 s, and 85% used adequate inspiratory pressures. Airway patency was ensured 83% (IQR 76–92) of the time. Median events/min, compression rate, and percentage of effective compressions were 138/min (IQR 130–145), 120/min (IQR 114–120), and 38% (IQR 24–48), respectively. Other adherence percentages were temperature management 50%, auscultation of initial heart rate 100%, pulse oximeter use 94%, oxygen increase 74%, and correct epinephrine dose 82%. Ten publications were identified and used for our framework. The framework may inspire clinicians, educators, researchers, and guideline developers in their attempt to improve resuscitation guideline adherence. It contains many feasible strategies to enhance professionals’ knowledge, skills, self-efficacy, and team performance, as well as recommendations regarding equipment, environment, and guideline development/dissemination.Conclusion: NLS guideline adherence among pediatricians needs improvement. Our framework is meant to promote resuscitation guideline adherence.

What is Known:• Inadequate newborn life support (NLS) may contribute to (long-term) pulmonary and cerebral damage.• Video-based assessment of neonatal resuscitations has shown that deviations from the NLS guideline occur frequently; this assessment method has its audiovisual shortcomings.

What is New:• The resuscitation quality metrics provided by our high-fidelity manikin suggest that the adherence of Dutch general pediatricians to the NLS guideline is suboptimal.• We constructed a comprehensive framework, containing multiple strategies to improve (neonatal) resuscitation guideline adherence.
The implications of complexity for humanitarian logistics: a complex adaptive systems perspective
Authors: Schiffling Sarah , Hannibal Claire , Tickle Matthew , Fan Yiyi 
Published: May 2020

AbstractIn this study we argue that recognising humanitarian logistics (HL) as a complex system is a key step in developing supply chain design and management strategies that meet the needs of stakeholders. This study draws on complex adaptive systems theory to examine the characteristics and implications of complexity for HL. Through case-study research of humanitarian responses in Haiti and Pakistan, characteristics of complexity across organisational boundaries are identified. We find that the complexity of the context impacts the outcome of the humanitarian response and conclude that HL must not only react to its environment, it must also create its environment. As HL must work within significantly differing environments to create solutions, the standardised approaches used to manage supply chains are less desirable. While this paper focuses on HL, wider applicability to other complex logistics operations is also discussed, informing the design and management of contextually specific supply chains.
NADES-based fractionation of biomass to produce raw material for the preparation of cellulose acetates
Authors: Soto-Salcido L. A. , Anugwom I. , Ballinas-Casarrubias L. , Mänttäri M. , Kallioinen M. 
Published: May 2020

AbstractWaste biomass (agave bagasse) and native birch wood were used as raw materials for a novel fractionation and derivation process to produce cellulose acetates (CAs). During the first stage of the fractionation process, a significant amount of hemicelluloses and lignin were dissolved from the biomass using a natural deep eutectic solvent (NADES) that consisted of a mixture of choline chloride and lactic acid with the molar ratio of 1:9. Then, the residual solid material was delignified by bleaching it with a mixture of acetic acid and sodium chlorite. The fractionation process generated differently purified pulps (celluloses) which were converted to CAs. The crystallinity index, polymerization degree, chemical composition, and thermal properties of the differently purified pulps and CAs were analyzed to evaluate the efficacy of the acetylation process and to characterize the CAs. The chemical derivation of the differently purified cellulose samples generated CAs with different degrees of substitution (DSs). The more purified the cellulose sample was, the higher its DS was. Moreover, some differences were observed between the acetylation efficiencies of birch and agave bagasse. Typically, cellulose purified from birch by treating it with NADES followed by bleaching was acetylated more completely (DS = 2.94) than that derived from agave bagasse (DS = 2.45). These results revealed that using green solvents, such as NADES, to treat both agave bagasse (waste biomass) and birch wood, allowed pure fractions to be obtained from biomass, and thus, biomass could be valorized into products such as CAs, which present a wide range of applications.
Enhancing packaging board properties using micro- and nanofibers prepared from recycled board
Authors: Laitinen Ossi , Suopajärvi Terhi , Liimatainen Henrikki 
Published: May 2020

AbstractIn this study, cellulose microfibers and cellulose nanofibers (CNF) prepared from recycled boxboard pulp using a mechanical fine friction grinder were used as reinforcements in a board sheet. Micro- and nanofibers manufactured by mechanical grinding have typically broad particle size distribution, and they can contain both micro- and nano-sized fibrils. Deep eutectic solvent of choline chloride and urea was used as a non-hydrolytic pretreatment medium for the CNF, and reference CNF were used without any chemical pretreatment. The CNF were ground using three grinding levels (grinding time) and their dosage in the board varied from 2 to 6 wt%. The results indicate that the board properties could be tailored to obtain a balance between the processability and quality of the products by adjusting the amount of CNF that was added (2–6 wt%). A preliminary cost assessment indicated that the most economical way to enhance the board strength properties was to add around 4% of CNF with a moderate grinding level (i.e., grinding energy of 3–4 kWh/kg). Overall, the strength properties of the manufactured board sheets improved by several dozen percentages when CNF was used as the reinforcement.
Trace metal contamination in sediment in the Mhlathuze Estuary, northern KwaZulu-Natal, South Africa: effects on the macrobenthic community
Authors: Izegaegbe Joshua Idowu , Vivier Leon , Mzimela Hendrick Mduduzi 
Published: May 2020

AbstractMhlathuze Estuary constitutes one of the ecological most important estuaries in southern Africa and is regarded as an estuary of high conservation importance. The ongoing expansion of the adjacent industrialized Richards Bay Harbour increases the risk of metal pollution to the estuary. This study provides insight into the extent and sources of trace metal contamination using pollution indices and sediment quality guidelines and the effect on macrobenthic habitat quality. Sediment samples for sediment metal and macrobenthic analysis were collected quarterly during 2016–2017 at five sites in the estuary using a marine-grade Zabalocki grab. Metal concentrations were determined using an ICP-OES. Sediment metal concentrations were consistently highest in the subtidal mudflats and lowest in marine sand at the mouth of the estuary. Concentrations of all metals displayed significant differences between sites (P < 0.05). Pollution indices indicated moderate enrichment of Cr at all sites, although the mean pollution load index showed the estuary to be unpolluted. Comparison with sediment quality guidelines revealed that concentrations of Ni and Cr were potentially toxic to biota. Using multivariate analysis, metal concentrations appeared not to significantly affect the macrobenthic community. The multi-metric biotic index M-AMBI proved to be a robust tool in the habitat quality assessment of the estuary. The continuing use of M-AMBI as a biomonitoring tool for ecological management of the estuary is advocated.
Parts of Falling Objects: Galileo’s Thought Experiment in Mereological Setting
Authors: Gruszczyński Rafał 
Published: May 2020

AbstractThis paper aims to formalize Galileo’s argument (and its variations) against the Aristotelian view that the weight of free-falling bodies influences their speed. I obtain this via the application of concepts of parthood and of mereological sum, and via recognition of a principle which is not explicitly formulated by the Italian thinker but seems to be natural and helpful in understanding the logical mechanism behind Galileo’s train of thought. I also compare my reconstruction to one of those put forward by Atkinson and Peijnenburg (Stud Hist Philos Sci 35(1):115–136, 2004), and propose a formalization which is based on a principle introduced by them, which I shall call the speed is mediative principle.
Separation and Elevated Residential Mobility: A Cross-Country Comparison
Authors: Kulu Hill , Mikolai Júlia , Thomas Michael J. , Vidal Sergi , Schnor Christine , Willaert Didier , Visser Fieke H. L. , Mulder Clara H. 
Published: May 2020

AbstractThis study investigates the magnitude and persistence of elevated post-separation residential mobility (i.e. residential instability) in five countries (Australia, Belgium, Germany, the Netherlands, and the UK) with similar levels of economic development, but different welfare provisions and housing markets. While many studies examine residential changes related to separation in selected individual countries, only very few have compared patterns across countries. Using longitudinal data and applying Poisson regression models, we study the risk of a move of separated men and women compared with cohabiting and married individuals. We use time since separation to distinguish between moves due to separation and moves of separated individuals. Our analysis shows that separated men and women are significantly more likely to move than cohabiting and married individuals. The risk of a residential change is the highest shortly after separation, and it decreases with duration since separation. However, the magnitude of this decline varies by country. In Belgium, mobility rates remain elevated for a long period after separation, whereas in the Netherlands, post-separation residential instability appears brief, with mobility rates declining rapidly. The results suggest that housing markets are likely to shape the residential mobility of separated individuals. In countries, where mortgages are easy to access and affordable rental properties are widespread, separated individuals can rapidly adjust their housing to new family circumstances; in contrast, in countries with limited access to homeownership and small social rental markets, separated individuals experience a prolonged period of residential instability.
CircUBAP2 promotes SEMA6D expression to enhance the cisplatin resistance in osteosarcoma through sponging miR-506-3p by activating Wnt/β-catenin signaling pathway
Authors: Dong Lin , Qu Fangfei 
Published: May 2020

AbstractThe occurrence of chemo-resistance is an essential reason for the high morbidity of osteosarcoma (OS) patients. Circular RNAs (circRNAs) have been involved in the regulation of chemo-resistance in cancers. Semaphorins 6D (SEMA6D) is abnormally expressed in many cancers. However, the roles of circUBAP2 and SEMA6D in the chemo-resistance of OS are still unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of circUBAP2, SEMA6D and microRNA-506-3p (miR-506-3p). The cisplatin resistance and proliferation of cells were evaluated by 3-(4, 5-dimethyl-2 thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide assay. Western blot analysis was performed to measure the protein levels of Wnt/β-catenin signaling pathway biomarkers and SEMA6D. Also, the apoptosis, migration and invasion of cells were assessed by Flow cytometry and Transwell assays, respectively. Besides, Dual-luciferase reporter assay was used to verify the interaction between miR-506-3p and circUBAP2 or SEMA6D. We found that the expression levels of circUBAP2 and SEMA6D were increased in cisplatin-resistant OS tissues and cells. Knockdown of circUBAP2 inhibited the cisplatin resistance, silenced Wnt/β-catenin signaling pathway, hindered cell proliferation, migration and invasion, and promoted apoptosis in cisplatin-resistant OS cells, all of which could be reversed by overexpression of SEMA6D. MiR-506-3p could be sponged by circUBAP2 and could target SEMA6D. The suppression of miR-506-3p overexpression on the progression of OS cisplatin resistance could be reversed by SEMA6D overexpression, while miR-506-3p inhibitor also could invert the inhibitory effect of circUBAP2 silencing on the progression of OS cisplatin resistance. In conclusion, CircUBAP2 and SEMA6D played active roles in the progression of OS cisplatin resistance through miR-506-3p, which might provide some new ideas for studying the countermeasures of OS resistance.
School-based epidemiology study of myopia in Tianjin, China
Authors: Wang Jiaxing , Li Ying , Zhao Zhenyang , Wei Nan , Qi Xiaoli , Ding Gang , Li Xue , Li Jing , Song Linlin , Zhang Ying , Yi Richard Hyun , Ning Yuxian , Zeng Xiaoyu , Hua Ning , Qian Xuehan 
Published: May 2020

Abstract
Purpose
To study the epidemiology of myopia in school-aged children in Tianjin and the relationship between visual acuity-based screening and refraction-based screening.

Method
This school-based prospective cohort study was performed on children from 42 elementary schools and 17 middle schools in Tianjin, China. Totally 14,551 children, ages ranging from 5 to 16 years, were included in this study. Uncorrected visual acuity (UCVA) was determined by logarithmic tumbling E chart. Non-cycloplegic photorefraction was examined by the Spot (v2.1.4) photoscreener. The relationship between the UCVA and refractive error was investigated for different age groups.

Results
The overall prevalence of myopia at this school based screen is 78.2%, ranged from 10% at age of 5 to 95% at age of 16. The most dramatic increase in prevalence is from age of 6 (14.8%) to age of 7 (38.5%). The overall prevalence of high myopia is 2.5%. UCVA is found corresponding to spherical equivalent refraction (SER) in a manner of normal distribution and is significantly affected by age. When using UCVA to estimate the prevalence of myopia, the overall sensitivity and specificity are 0.824 and 0.820, respectively. Age-dependent optimal cutoff points and 95% confident intervals of such estimation are reported.

Conclusions
Myopia is heavily affecting school-aged children in Tianjin, China. The refraction screening is preferable for myopia screening, whereas the UCVA screening results need to be interpreted in an age-dependent manner for myopia estimation.
Teacher-Reported Prevalence of FASD in Kindergarten in Canada: Association with Child Development and Problems at Home
Authors: Pei Jacqueline , Reid-Westoby Caroline , Siddiqua Ayesha , Elshamy Yomna , Rorem Devyn , Bennett Teresa , Birken Catherine , Coplan Rob , Duku Eric , Ferro Mark A. , Forer Barry , Georgiades Stelios , Gorter Jan Willem , Guhn Martin , Maguire Jonathon , Manson Heather , Santos Rob , Brownell Marni , Janus Magdalena 
Published: May 2020

AbstractThe prevalence of Fetal Alcohol Spectrum Disorder (FASD) may be underestimated as it can be difficult to diagnose in early childhood possibly reflecting unique developmental trajectories relative to other Neurodevelopmental Disabilities (NDDs). Using data collected via the Early Development Instrument (EDI) between 2010 and 2015, we examined the prevalence of kindergarten children with FASD and their concurrent developmental outcomes. We found that the prevalence of FASD ranged from 0.01 to 0.31%. A greater percentage of children with FASD had teacher-reported home problems that interfered with their classroom functioning. Overall children with FASD had higher mean scores on the developmental domains compared to children with NDDs. Results of the current study can inform strategies and policies for early identification and intervention.
Unbounded-Time Safety Verification of Guarded LTI Models with Inputs by Abstract Acceleration
Authors: Cattaruzza Dario , Abate Alessandro , Schrammel Peter , Kroening Daniel 
Published: May 2020

AbstractReachability analysis of dynamical models is a relevant problem that has seen much progress in the last decades, however with clear limitations pertaining to the nature of the dynamics and the soundness of the results. This article focuses on sound safety verification of unbounded-time (infinite-horizon) linear time-invariant (LTI) models with inputs using reachability analysis. We achieve this using counterexample-guided Abstract Acceleration: this approach over-approximates the reachability tube of the LTI model over an unbounded time horizon by using abstraction, possibly finding concrete counterexamples for refinement based on the given safety specification. The technique is applied to a number of LTI models and the results show robust performance when compared to state-of-the-art tools.
Structural Characterization and Magnetic Interactions of La0.7Sr0.25Na0.05Mn1 - xAlxO3
Authors: Zaidi N. , Elabassi Mounira , Selmi Marwa , Hlil E. K. 
Published: May 2020

AbstractThe magnetocaloric properties of manganite oxides La0.7Sr0.25Na0.05Mn1 − xAlxO3 (LSNMAlx) synthesized by sol-gel method were studied in detail. X-ray diffraction analyses showed a single rhombohedral phase with the R3-c space group. The inhomogeneous magnetic compartment coupled with the core-shell behavior was used to explain the magnetic properties and the evolution of the paramagnetic-ferromagnetic transition of the materials. Using a phenomenological model, the maximum values of magnetic entropy change (ΔSmax) decreased from 4.92 J kg−1 K for La0.7Sr0.25Na0.05MnO3 to 3.84 J kg−1 K for La0.7Sr0.25Na0.05Mn0.95Al0.05O3 upon an applied magnetic field of μ0H = 5 T, indicating an excellent quality of our samples as compared to many manganite oxides. The high quality of our samples was also checked by the large relative cooling power (RCP) which provides a good performance for industrial technologies in refrigeration devices.
Well-Posedness for a Whitham–Boussinesq System with Surface Tension
Authors: Dinvay Evgueni 
Published: May 2020

AbstractWe regard the Cauchy problem for a particular Whitham–Boussinesq system modelling surface waves of an inviscid incompressible fluid layer. The system can be seen as a weak nonlocal dispersive perturbation of the shallow water system. The proof of well-posedness relies on energy estimates. However, due to the symmetry lack of the nonlinear part, in order to close the a priori estimates one has to modify the traditional energy norm in use. Hamiltonian conservation provides with global well-posedness at least for small initial data in the one dimensional settings.
Firm size and growth barriers: a data-driven approach
Authors: Karlsson Johan 
Published: May 2020

AbstractThis article aims to capture the relationship between perceived growth barriers and firm size. This aim is pursued by developing a novel data-driven identification strategy that assigns firm size groups based on their statistical relationships to perceived growth barriers. The analysis is undertaken using data for approximately 44,000 Swedish SMEs (0–249 employees) for 2011, 2014, and 2017. The results suggest that small firms typically face constraints on equity financing, whereas larger firms face barriers regarding competition and recruitment. As a benchmark, the performance of the developed method is compared with prevailing strategies that use ad hoc firm size groups. The findings show that ad hoc groups fail to accurately capture size thresholds at which firms incur barriers, and they yield a consistently lower model fit compared with the method proposed here. Consequently, there may be a need for methodological rethink in the field regarding the treatment of firm size.