bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wilm's Tumor-Collaborative Approach is needed to Prevent Tumor Upstaging and Radiotherapy Delays: A Single Institutional Study
Authors: Wani Shaqul Qamar , Khan Talib , Wani Saiful Yammin , Lone Mohammad Maqbool , Afroz Fir 
Published: December 2019

Abstract
Context: Successful management of Wilm's tumor (WT) necessitates meticulous attention for proper staging and collaborative effort for its optimal management. Aims: The aim of the study was to observe the patterns of WT. Settings and Design: This study was a single-institutional retrospective study. Subjects and Methods: Twenty-three WT case records were analyzed over 6 years and the data collected were interpreted as number, percent, mean ± and standard deviation with regard to clinicodemographic aspects, staging, and diagnostic modality and treatment options. Results: Mean age was 3.97 ± 2.67 years with maximum number in the 2–5-year age group. Males slightly dominated the number, and majority cases were from the rural area. The major clinical presentation was abdominal mass followed by abdominal pain, fever, vomiting, hematuria, and urinary retention. Left laterality was common and single bilateral WT was seen. Majority of tumors were >10 cm in their largest dimensions. Most WT presented in Stage III followed by Stage I and IV. One was a recurrent tumor. Conclusion: WT was usually diagnosed at the locally advanced or metastatic stages; hence, the comprehensive collaborative approach will help to manage the patients optimally and avoid tumor upstaging and radiotherapy delays. Besides awareness at community level is needed to pick up the disease at the earlier stage to have a better outcome in the form of disease control and disease-free survival.
Postpartum depression burden and associated factors in mothers of infants at an urban primary health center in Delhi, India
Authors: Basu Saurav , Budh Nidhi , Garg Suneela , Singh Mongjam Meghachandra , Sharma Akashdeep 
Published: December 2019

Objective:
Postpartum depression is a nonpsychotic mental health condition that impairs both the immediate and long-term health of both the mother and her child.

Materials and Methods:
We conducted a cross-sectional study from January to June 2019 at a primary care clinic in Delhi, India, to estimate the burden of postpartum depression in women having an infant child. The Hindi version of the Edinburgh Postnatal Depression Scale was used to screen for the depression in the participants. Data were analyzed with IBM SPSS software version 25. P <0.05 was considered statistically significant.

Results:
A total of 210 women were screened, and 61 (29%) were detected with postpartum depression. On multivariate analysis, women reporting low and medium levels of perceived social support had significantly higher odds of having postpartum depression. However, depressive symptoms were not associated with the sex and age of the infant or even the sex composition of the women's other children.

Conclusion:
Postpartum depression represents a major public health challenge in India. Regular, mandatory screening for postpartum depression is needed at primary health facilities in resource-constrained settings for an extended period postchildbirth.
Modern American Drama: Playwriting in the 1980s
Authors: Shannon Sandra G. 
Published: December 2019

The Decades of Modern American Playwriting series provides a comprehensive survey and study of the theatre produced in each decade from the 1930s to 2009 in eight volumes. Each volume equips readers with a detailed understanding of the context from which work emerged: an introduction considers life in the decade with a focus on domestic life and conditions, social changes, culture, media, technology, industry and political events; while a chapter on the theatre of the decade offers a wide-ranging and thorough survey of theatres, companies, dramatists, new movements and developments in response to the economic and political conditions of the day. The work of the four most prominent playwrights from the decade receives in-depth analysis and re-evaluation by a team of experts, together with commentary on their subsequent work and legacy. A final section brings together original documents such as interviews with the playwrights and with directors, drafts of play scenes, and other previously unpublished material.
The major playwrights and their plays to receive in-depth coverage in this volume include:David Mamet: Edmond (1982), Glengarry Glen Ross (1984), Speed-the-Plow (1988) and Oleanna (1992);David Henry Hwang: Family Devotions (1981), The Sound of a Voice (1983) and M. Butterfly (1988);Maria Irene Fornès: The Danube (1982), Mud (1983) and The Conduct of Life (1985);August Wilson: Ma Rainey’s Black Bottom (1984), Joe Turner’s Come and Gone (1984) and Fences (1987).
La gestion des informations dans le cadre de l’analyse criminelle de la délinquance sexuelle sérielle
Authors: Chopin12 Julien , Aebi Marcelo F. 
Published: December 2019

Cette recherche s’intéresse à la quantité d’information nécessaire aux systèmes de gestion des liens permettant d’identifier les cas sériels de criminalité violente. L’objectif de cette recherche est de tester empiriquement et de discuter de la pertinence de réduire le contenu de ces outils. Les données utilisées proviennent d’une extraction de la base de données du ViCLAS en France. Les analyses portent sur un échantillon de variables les plus utilisées dans le cadre des agressions sexuelles. Des analyses descriptives et factorielles sont utilisées pour déterminer quelles informations sont collectées par les policiers et comment elles pourraient être réduites empiriquement en agrégeant les données corrélées. Les résultats montrent qu’environ 65 % des modalités testées sont utilisées dans moins de 5 % des cas d’agressions sexuelles. Les résultats des analyses factorielles montrent qu’il est possible de réduire drastiquement l’outil. Les implications pratiques de ces résultats sont discutées dans une perspective d’investigation policière.
Processus de changement des adolescents auteurs de violences sexuelles
Authors: Roman1 Pascal , Cuttelod Thérèse , Espeil-Marc Sylvie , Gorry Dorothée , Lavèze Frédérique , Ravit Magali 
Published: December 2019

Cet article présente les principales avancées issues d’une recherche menée conjointement sur deux sites cliniques, en Suisse et en France, et consacrée à l’évaluation des processus de changement des adolescents auteurs de violences sexuelles. L’objectif est de dégager les principaux indicateurs cliniques de ces changements, à partir d’une étude longitudinale portant sur un petit nombre d’adolescents (N =9), engagés dans une démarche psychothérapeutique sous mandat judiciaire en groupe. L’étude s’appuie sur une démarche qualitative, qui associe principalement deux types de recueil de données cliniques : épreuves projectives en test-retest d’une part et enregistrement des verbatims de séances de groupe d’autre part. À partir de l’analyse croisée de ces données, un certain nombre d’indicateurs cliniques peuvent être mis en évidence, qui permettent d’esquisser une modélisation des processus de changement chez les adolescents. Au-delà, les éléments de compréhension qui émergent de la recherche permettent de tracer des perspectives pour le soin psychothérapeutique des adolescents.
L’évolution du réseau social des femmes victimes de violence conjugale
Authors: Nolet1 Anne-Marie , Morselli Carlo , Cousineau Marie-Marthe 
Published: December 2019

Cet article vise à analyser l’évolution du réseau social des femmes victimes de violence conjugale en référence au concept d’autonomie relationnelle, défini comme une liberté de choisir parmi un ensemble diversifié d’options. Des entrevues individuelles ont été réalisées avec 30 femmes victimes de violence conjugale, permettant de dégager quatre étapes à travers lesquelles leur réseau change dans le temps : la relation violente, la rupture, le suivi en maison d’hébergement et le post-suivi. Les données sont analysées à partir des mesures de contrainte et de contrainte dyadique, qui permettent de saisir dans quelle mesure les femmes sont enfermées dans leur réseau social et/ou dans des relations avec certains acteurs en particulier. La contrainte des femmes diminue avec la rupture et le passage en maison d’hébergement, puis augmente pour la période post-suivi. Les relations contraignantes, principalement négatives et mitigées pendant la relation violente et la rupture, deviennent de plus en plus positives avec le passage en maison d’hébergement et le post-suivi. Les implications de ces résultats pour l’intervention et la recherche sont discutées.
Migraine aura, a predictor of near-death experiences in a crowdsourced study
Authors: Kondziella Daniel , Olsen Markus Harboe , Lemale Coline L. , Dreier Jens P. 
Published: December 2019

Background
Near-death experiences (NDE) occur with imminent death and in situations of stress and danger but are poorly understood. Evidence suggests that NDE are associated with rapid eye movement (REM) sleep intrusion, a feature of narcolepsy. Previous studies further found REM abnormalities and an increased frequency of dream-enacting behavior in migraine patients, as well as an association between migraine with aura and narcolepsy. We therefore investigated if NDE are more common in people with migraine aura.

Methods
We recruited 1,037 laypeople from 35 countries and five continents, without any filters except for English language and age ≥18 years, via a crowdsourcing platform. Reports were validated using the Greyson NDE Scale.

Results
Eighty-one of 1,037 participants had NDE (7.8%; CI [6.3–9.7%]). There were no significant associations between NDE and age (p > 0.6, t-test independent samples) or gender (p > 0.9, Chi-square test). The only significant association was between NDE and migraine aura: 48 (6.1%) of 783 subjects without migraine aura and 33 (13.0%) of 254 subjects with migraine aura had NDE (p < 0.001, odds ratio (OR) = 2.29). In multiple logistic regression analysis, migraine aura remained significant after adjustment for age (p < 0.001, OR = 2.31), gender (p < 0.001, OR = 2.33), or both (p < 0.001, OR = 2.33).

Conclusions
In our sample, migraine aura was a predictor of NDE. This indirectly supports the association between NDE and REM intrusion and might have implications for the understanding of NDE, because a variant of spreading depolarization (SD), terminal SD, occurs in humans at the end of life, while a short-lasting variant of SD is considered the pathophysiological correlate of migraine aura.
Comparative Antibacterial Analysis and Synergistic Potency of the Leaf Extracts of Ocimum gratissimum Linn. and Gongronema latifolium Benth. on Some Enteric Bacterial Isolates
Authors: Awomukwu D. A. , Anumudu C. K. , Ogbolosingha A. J. 
Published: December 2019

The research was undertaken to investigate the comparative phytochemical and in-vitro antibacterial activity of the single and combined strengths of the leaf extracts of Ocimum gratissimum Linn and Gongronema latifolium Benth. on some enteric bacterial isolates. The sensitivity test and minimum inhibitory concentration (MIC) were carried out using a modified agar-well diffusion method. The enteric bacterial isolates tested included Escherichia coli, Shigella dysenteriae, Salmonella Typhi and Enterobacter aerogenes. Standard methods were applied to obtain the ethanol and aqueous leaf extracts. The ethanol extracts of O. gratissimum and G. latifolium produced highly significant inhibitory activity against all the enteric bacterial isolates tested. Comparatively, the ethanol plant extracts were more potent than the commercially available drug, Ciprofloxacin and the aqueous plant extracts. The isolates were sensitive at a minimum inhibitory concentration of 1.25 mg/ml for the ethanol extract but varied from 2.5 mg/ml - 5.0mg/ml in the aqueous extract. It was also observed that the synergistic antibacterial effect of the medicinal plant extracts was greater than the singular antibacterial effect of the individual plant extracts in both the ethanol and aqueous extracts. The potency of the individual extracts and the combined effect may be due to the presence of flavonoids, alkaloids, phenols, tannins and saponins in the leaves of the plants. This study partly validates the use of the plant extracts in the treatment of disease caused by the enteric bacterial isolates by multiple traditional medicine practitioners in Nigeria, however, strict adherence to dosage is recommended. The leaf extract is a potential source of the new drug if the components are purified and enhanced for treating infections caused by these enteric pathogens.
Fluorescent Polysaccharide Nanogels for the Detection of Tumor Heterogeneity in Drug‐Surviving Cancer Cells
Authors: Wang Chenglong , Wang Fanchen , Zhang Jinguo , Liu Lingshan , Xu Guoxiong , Dou Hongjing 
Published: December 2019

AbstractTumor metastasis, recurrence, and drug resistance have been associated with tumor heterogeneity, and thus the identification of tumor heterogeneity has great significance in medicine. The approach provides a way to identify and isolate various cell subtypes from drug‐surviving ovarian cancer cells, by synthesizing a series of polysaccharide nanogels and using them in flow cytometry analysis. The results show that the drug‐surviving OVCAR‐3 cells that are subjected to paclitaxel intervention comprise various cell subtypes, including drug‐resistant and non‐drug‐resistant cell subtypes. Besides, there are significant differences between the drug‐resistant cell subtype and non‐drug‐resistant cell subtype in terms of their migration and invasion behavior. In addition, the phenotype switch genes are detected by mRNA sequencing, and it is found that different subtypes show significant genetic differences with regard to their drug resistance, metastasis, and proliferation. In particular, modifying polysaccharide nanogels with lipids can promote the uptake of nanogels by drug‐resistant cells, and thus the lipid modification can enhance the effectiveness of a chemotherapy drug carrier against drug‐resistant cells. These studies reveal the heterogeneity of drug‐surviving tumor cells, as well as the significant differences in drug‐resistance, migration, and invasion capabilities of different subtypes, and demonstrate a way to overcome drug resistance.
Enhanced Thermal Stability of Halide Perovskite CsPbX3 Nanocrystals by a Facile TPU Encapsulation
Authors: Shi Jindou , Ge Wanyin , Gao Wenxing , Xu Meimei , Zhu Jianfeng , Li Yongxiang 
Published: December 2019

AbstractImproving the stability of all‐inorganic halide perovskite nanocrystals has become an urgent task that cannot be ignored in practical applications. Lead halide perovskite CsPbX3 (X = Br, I, Cl) compounds are considered as the potential materials for next‐generation light‐emitting devices due to their superior optical properties. However, they are threatened by thermal degradation and atmospheric moisture. In order to better solve this practical problem, CsPbBr3 quantum dots (QDs) and CsPbBr3@Cs4PbBr6 nanocrystals (NCs) are tested under heating and cooling cycles, and the photoluminescence (PL) intensity loss of different perovskite materials at high temperatures is investigated. In addition, a thermoplastic polyurethane encapsulation strategy is proposed to improve their properties of thermal degradation and moisture resistance. This inexpensive and convenient method not only greatly reduces the PL intensity loss, but also shows excellent PL performance even in water. The encapsulated material has both flexible and elastic properties, which paves the way for the next commercial processing of all inorganic perovskite materials.
Stereoselective Syntheses, Structures, and Properties of Extremely Distorted Chiral Nanographenes Embedding Hextuple Helicenes
Authors: Roy Myriam , Berezhnaia Veronika , Villa Marco , Vanthuyne Nicolas , Giorgi Michel , Naubron Jean‐Valère , Poyer Salomé , Monnier Valérie , Charles Laurence , Carissan Yannick , Hagebaum‐Reignier Denis , Rodriguez Jean , Gingras Marc , Coquerel Yoann 
Published: December 2019

AbstractWe report a molecular design and concept using π‐system elongation and steric effects from helicenes surrounding a triphenylene core toward stable chiral polycyclic aromatic hydrocarbons (PAHs) with a maximal π‐distortion to tackle their aromaticity, supramolecular and molecular properties. The selective syntheses, and the structural, conformational and chiroptical properties of two diastereomeric large multi‐helicenes of formula C90H48having a triphenylene core and embedding three [5]helicene units on their inner edges and three [7]helicene units at their periphery are reported based on diastereoselective and, when applicable, enantiospecific Yamamoto‐type cyclotrimerizations of racemic or enantiopure 9,10‐dibromo[7]helicene. Both molecules have an extremely distorted triphenylene core, and one of them exhibits the largest torsion angle recorded so far for a benzene ring (twist=36.9°).
Atomistic Simulations of COSAN: Amphiphiles without a Head‐and‐Tail Design Display “Head and Tail” Surfactant Behavior
Authors: Malaspina David C. , Viñas Clara , Teixidor Francesc , Faraudo Jordi 
Published: December 2019

AbstractCobaltabisdicarbollide (COSAN) anions have an unexpectedly rich self‐assembly behavior, which can lead to vesicles and micelles without having a classical surfactant molecular architecture. This was rationalized by the introduction of new terminology and novel driving forces. A key aspect in the interpretation of COSAN behavior is the assumption that the most stable form of these ions is the transoid rotamer, which lacks a “hydrophilic head” and a “hydrophobic tail”. Using implicit solvent DFT calculations and MD simulations we show that in water, 1) the cisoid rotamer is the most stable form of COSAN and 2) this cisoid rotamer has a well‐defined hydrophilic polar region (“head”) and a hydrophobic apolar region (“tail”). In addition, our simulations show that the properties of this rotamer in water (interfacial affinity, micellization) match those expected for a classical surfactant. Therefore, we conclude that the experimental results for the COSAN ions can now be understood in terms of its amphiphilic molecular architecture.
Visible‐Light‐Driven Halogen Bond Donor Based Molecular Switches: From Reversible Unwinding to Handedness Inversion in Self‐Organized Soft Helical Superstructures
Authors: Wang Hao , Bisoyi Hari Krishna , Li Bing‐Xiang , McConney Michael E. , Bunning Timothy J. , Li Quan 
Published: December 2019

AbstractVisible‐light‐driven molecular switches endowing reversible modulation of the functionalities of self‐organized soft materials are currently highly sought after for fundamental scientific studies and technological applications. Reported herein are the design and synthesis of two novel halogen bond donor based chiral molecular switches that exhibit reversible photoisomerization upon exposure to visible light of different wavelengths. These chiral molecular switches induce photoresponsive helical superstructures, that is, cholesteric liquid crystals, when doped into the commercially available room‐temperature achiral liquid crystal host 5CB, which also acts as a halogen‐bond acceptor. The induced helical superstructure containing the molecular switch with terminal iodo atoms exhibits visible‐light‐driven reversible unwinding, that is, a cholesteric–nematic phase transition. Interestingly, the molecular switch with terminal bromo atoms confers reversible handedness inversion to the helical superstructure upon irradiation with visible light of different wavelengths. This visible‐light‐driven, reversible handedness inversion, enabled by a halogen bond donor molecular switch, is unprecedented.
Crystal‐to‐Crystal Synthesis of Helically Ordered Polymers of Trehalose by Topochemical Polymerization
Authors: Hema Kuntrapakam , Gonnade Rajesh G. , Sureshan Kana M. 
Published: December 2019

AbstractThe synthesis of crystalline helical polymers of trehalose via topochemical azide–alkyne cycloaddition (TAAC) of a trehalose‐based monomer is presented. An unsymmetrical trehalose derivative having azide and alkyne crystallizes in two different forms having almost similar packing. Upon heating, both the crystals undergo TAAC reaction to form crystalline polymers. Powder X‐ray diffraction (PXRD) studies revealed that the monomers in both the crystals polymerize in a crystal‐to‐crystal fashion; circular dichroism (CD) studies of the product crystals revealed that the formed polymer is helically ordered. This solvent‐free, catalyst‐free polymerization method that eliminates the tedious purification of the polymeric product exemplifies the advantage of topochemical polymerization reaction over traditional solution‐phase polymerization.
Endogenous Nanoparticles Strain Perovskite Host Lattice Providing Oxygen Capacity and Driving Oxygen Exchange and CH4 Conversion to Syngas
Authors: Kousi Kalliopi , Neagu Dragos , Bekris Leonidas , Papaioannou Evangelos I. , Metcalfe Ian S. 
Published: December 2019

AbstractParticles dispersed on the surface of oxide supports have enabled a wealth of applications in electrocatalysis, photocatalysis, and heterogeneous catalysis. Dispersing nanoparticles within the bulk of oxides is, however, synthetically much more challenging and therefore less explored, but could open new dimensions to control material properties analogous to substitutional doping of ions in crystal lattices. Here we demonstrate such a concept allowing extensive, controlled growth of metallic nanoparticles, at nanoscale proximity, within a perovskite oxide lattice as well as on its surface. By employing operando techniques, we show that in the emergent nanostructure, the endogenous nanoparticles and the perovskite lattice become reciprocally strained and seamlessly connected, enabling enhanced oxygen exchange. Additionally, even deeply embedded nanoparticles can reversibly exchange oxygen with a methane stream, driving its redox conversion to syngas with remarkable selectivity and long term cyclability while surface particles are present. These results not only exemplify the means to create extensive, self‐strained nanoarchitectures with enhanced oxygen transport and storage capabilities, but also demonstrate that deeply submerged, redox‐active nanoparticles could be entirely accessible to reaction environments, driving redox transformations and thus offering intriguing new alternatives to design materials underpinning several energy conversion technologies.
Synthesis of Copper‐Substituted CoS2@CuxS Double‐Shelled Nanoboxes by Sequential Ion Exchange for Efficient Sodium Storage
Authors: Fang Yongjin , Luan Deyan , Chen Ye , Gao Shuyan , Lou Xiong Wen (David) 
Published: December 2019

AbstractThe construction of hybrid architectures for electrode materials has been demonstrated as an efficient strategy to boost sodium‐storage properties because of the synergetic effect of each component. However, the fabrication of hybrid nanostructures with a rational structure and desired composition for effective sodium storage is still challenging. In this study, an integrated nanostructure composed of copper‐substituted CoS2@CuxS double‐shelled nanoboxes (denoted as Cu‐CoS2@CuxS DSNBs) was synthesized through a rational metal–organic framework (MOF)‐based templating strategy. The unique shell configuration and complex composition endow the Cu‐CoS2@CuxS DSNBs with enhanced electrochemical performance in terms of superior rate capability and stable cyclability.