bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Planning in Liver Transplant: Patient and Provider Knowledge and Practices
Authors: Ritchie Julia , Seidman Dominika , Srisengfa Yanin , Perito Emily R. , Sarkar Monika 
Published: June 2020

Fertility is often impaired in adolescents and women with cirrhosis, but it is rapidly restored after liver transplantation (LT). Early and unplanned pregnancies confer increased risks to maternal, fetal, and graft health, underscoring the need for reproductive counseling. However, data on reproductive practices or counseling in the LT setting are limited. An anonymous online Qualtrics (Provo, UT) survey was sent to transplant patients and providers to gauge knowledge and practices surrounding contraception and pregnancy. Eligible participants included transplant patients aged 14‐45 years and their transplant providers. Patient response was 50.0% (74/148), 14 of whom were pre‐LT patients and 60 of whom were post‐LT patients. Counseling occurred in 37% of patients prior to transplant and 82% after transplant. Most patients (86%) considered family planning a high priority in their transplant care. Contraception‐ and pregnancy‐specific counseling was provided by LT providers in 60% and 44% of patients, respectively. The most desired mode of counseling by patients was in‐person discussion with an LT provider (89%). Despite most post‐LT patients receiving counseling, only 41% used contraception during the first year after LT, of whom 32% relied on high failure methods. Of the 31/43 (72.1%) provider responses, 96% voiced interest in additional reproductive education. Most providers (90%) correctly advised that patients delay pregnancy during the first year after LT, although misconceptions about safety of estrogen and intrauterine devices were selected by 53% and 42%, respectively. Some favored resources by providers were educational pamphlets in clinic (88%) and automated note templates to prompt family planning inquiry (72%). Transplant patients and providers have key deficiencies in their knowledge of contraception and corresponding practices. Most post‐LT patients receive counseling, yet contraception practices are inadequate for preventing unplanned pregnancy. Discussion with transplant providers was the most favored counseling modality by patients, underscoring our critical role in optimizing post‐LT reproductive care.
In Situ‐Forming Glucose‐Responsive Hydrogel from Hyaluronic Acid Modified with a Boronic Acid Derivative
Authors: Holz Emily , Rajagopal Karthikan 
Published: June 2020

AbstractHydrogels are a promising class of biomaterials for sustained drug release applications. The use of covalently cross‐linked hydrogels for drug delivery applications may be limited due to their manufacturing complexity and the high injection forces required for their administration. Stimulus‐responsive hydrogels, which are engineered to respond to stimuli such as pH, temperature, ionic strength, or chemical potential, may overcome these shortcomings and enable the development of injectable hydrogels. This study presents a strategy for forming hydrogels such that a sol–gel transition occurs in response to physiologically relevant glucose concentrations. A hyaluronic acid (HA) polymer backbone is modified with 3‐aminophenylboronic acid, which is able to reversibly bind glucose with a 2:1 stoichiometry. The boronic acid‐functionalized polymer is demonstrated to be glucose responsive, as indicated by its spontaneous hydrogelation and subsequent increase in stiffness as a function of glucose concentration. Furthermore, the transient nature of the boronic acid‐glucose cross‐linking enables the hydrogel to self‐heal after physical rupture. A proof‐of‐concept gelation in alkaline conditions is demonstrated, but the system may be adapted for gelation at physiological pH using modified boronic acids. These HA–boronic acid conjugates have potential utility as in situ‐forming hydrogels for sustained drug release applications.
Monochorionic diamniotic twins of discordant external genitalia with 45,X/46,XY mosaicism
Authors: Takahashi Ken , Sato Taisuke , Nishiyama Miyuki , Sasaki Aiko , Taniguchi Kosuke , Migita Ohsuke , Wada Seiji , Hata Kenichiro , Sago Haruhiko 
Published: June 2020

AbstractBackgroundMonozygotic twins with 45,X/46,XY mosaicism, discordant for phenotypic sex, are extremely rare.MethodsThis report describes the clinical findings of a rare case of 45,X/46,XY mosaicism in monozygotic twins with different external genitalia. Single nucleotide polymorphism (SNP) array analysis, performed by collecting DNA from each umbilical cord, showed identical SNPs in the autosomal chromosomes of both fetuses.ResultsChorionic villus sampling of a 37‐year‐old primigravida carrying monozygotic twins revealed a 45,X/46,XY karyotype. Autopsy of the aborted fetuses revealed a penis and testes on one fetus and a vagina, uterus, and ovaries in the other fetus––which also had severe cystic hygroma. Cell counting using fluorescence in situ hybridization with XY probes (XY‐FISH) showed 20% and 80% abundance of 45,X cells in the internal genitalia, liver, heart, lung, adrenal gland, bone marrow, and spine of the male and female fetuses, respectively.ConclusionThese results indicated that the fetuses were genetically monozygotic twins and their different degrees of mosaicism may have resulted in different genital phenotypes.
A structurally damped σ‐evolution equation with nonlinear memory
Authors: D'Abbicco Marcello , Girardi Giovanni 
Published: June 2020

In this paper, we investigate the global (in time) existence of small data solutions to the Cauchy problem for the following structurally damped σ‐evolution model with nonlinear memory term:

with σ>0. In particular, for γ∈((n−σ)/n,1), we find the sharp critical exponent, under the assumption of small data in L1. Dropping the L1 smallness assumption of initial data, we show how the critical exponent is consequently modified for the problem. In particular, we obtain a new interplay between the fractional order of integration 1−γ in the nonlinear memory term and the assumption that initial data are small in Lm, for some m>1.
Scavenger Receptor Class B Type I is Required for 25‐Hydroxycholecalciferol Cellular Uptake and Signaling in Myeloid Cells
Authors: Tenesaca Shirley , Vasquez Marcos , Fernandez‐Sendin Myriam , Di Trani Claudia Augusta , Ardaiz Nuria , Gomar Celia , Cuculescu Doina , Alvarez Maite , Otano Itziar , Melero Ignacio , Berraondo Pedro 
Published: June 2020

ScopeVitamin D3 is a critical molecule for the properly controlled activity of the immune system. In myeloid‐derived cells, vitamin D3 induces the production of the antimicrobial and antitumor peptide cathelicidin. In this study, the mechanism of the entry of 25‐hydroxycholecalciferol (25(OH)D) in myeloid‐derived cells is explored.Methods and resultsHere, a novel regulatory pathway of vitamin D3 biology is described. Using a polyclonal antibody, two different chemical inhibitors, and a high‐density lipoprotein as a competing ligand, it is demonstrated here that the 25(OH)D signaling pathway in myeloid cells depends on scavenger receptor class B type I (SR‐B1). This effect is observed in the THP‐1 monocytic cell line and in human primary monocytes. SR‐B1 blockade abrogates the cellular uptake of 25(OH)D leading to a general shut down of the gene transcription program modulated by 25(OH)D. The results obtained at the transcriptional level are confirmed at the protein and functional level for CD14 in the THP‐1 cell line.ConclusionIn conclusion, SR‐B1 plays a critical role in vitamin D3 biology, paving the way for novel therapeutic interventions.
CL‐MIPv6: A cross‐layer approach for fast‐internetwork‐mobility support in 6LoWPAN wireless sensor networks
Authors: Hamidi‐Alaoui Zakaria , Moussa Noureddine , El Belrhiti El Alaoui Abdelbaki 
Published: June 2020

SummaryConsidered as part of the Internet of Things (IoT) concept, Internet‐connected wireless sensor networks (WSNs) are increasingly using sensor nodes with mobility option. The mobility of sensor nodes is not necessarily limited within a single WSN but could also be across several WSNs. From this, efficiency, flexibility, and interoperability with the existing infrastructure are mandatory features. Unfortunately, current mobility management solutions are not optimized sufficiently for WSNs. In this paper, we propose a new solution (named as CL‐MIPv6) that uses detected link‐layer information with an adapted scheme of the standard MIPv6 to provide constrained mobile nodes with fast, reliable, and low‐cost internetwork handoffs. The idea behind our proposal consists of enabling reliable internetwork mobility anticipation, fast foreign‐network detection, and then processing low‐overhead handoff‐related signaling at mobile nodes. The evaluation of the proposed solution has demonstrated remarkable improvements in terms of reliability and energy‐latency costs of internetwork handoffs. The advantage of the contribution over its counterparts becomes more significant as the mobility speed and the overall network traffic load increase.
Routing electric vehicles with a single recharge per route
Authors: Löffler Maximilian , Desaulniers Guy , Irnich Stefan , Schneider Michael 
Published: June 2020

AbstractDriven by environmental considerations, regulations on vehicle emissions, and the offer of major subsidies, electric commercial vehicles (ECVs) are receiving ever stronger attention in logistics companies. Route planning for ECV fleets requires consideration of the special characteristics of ECVs, like limited driving range and the potential need to recharge en route at dedicated recharging stations. From a practical viewpoint, the number of recharge operations of each vehicle can very often be restricted to one recharge per route because (i) typical route distances in the most important application areas of ECVs, like small package shipping and food or beverage distribution, do not require more than one recharge given the current driving range of ECVs, and (ii) operations managers are very reluctant to plan vehicle routes with two or more recharges because recharging operations are perceived as unproductive idle times. We develop a simple hybrid of large neighborhood search and granular tabu search to solve the resulting electric vehicle‐routing problem with time windows and single recharge (EVRPTWS), considering the possibility of both full and partial recharge. The heuristic works on routes represented as customer sequences, and recharge operations are implicitly considered by determining the recharging position in the route, the recharging station to visit, and the amount to be recharged in optimal fashion. We discuss how our algorithm can be extended to handle nonlinear recharging times, different recharging times per station, and time‐dependent waiting times at stations. In numerical studies on EVRPTWS instances from the literature, the method provides optimal or near‐optimal solutions for instances with up to 100 customers within reasonable runtimes. Additional studies investigate the cost savings potential of partial recharges in comparison to full recharges in the presence of time‐window constraints, and examine the factors that influence this cost saving potential.
Meta‐analysis of the risk of autoimmune thyroiditis, Guillain‐Barré syndrome, and inflammatory bowel disease following vaccination with AS04‐adjuvanted human papillomavirus 16/18 vaccine
Authors: Rosillon Dominique , Willame Corinne , Tavares Da Silva Fernanda , Guignard Adrienne , Caterina Sophie , Welby Sarah , Struyf Frank 
Published: June 2020

AbstractPurposeTo assess the risk of three autoimmune diseases ‐ autoimmune thyroiditis (AIT), Guillain‐Barré syndrome (GBS), and inflammatory bowel disease (IBD) ‐ in females following AS04‐HPV‐16/18 vaccination.MethodsThis meta‐analysis included data from 18 randomized controlled trials, one cluster‐randomized trial, two large observational retrospective cohort studies, and one case‐control study. Following vaccination, a risk window of 2 years was defined for AIT and IBD and 42 days for GBS. Odds ratios (ORs) were estimated using three methods: meta‐analysis inverse‐variance with continuity correction (primary analysis), pooled estimate, and beta‐binomial regression.ResultsIn all studies apart from the case‐control study, 154 398 exposed and 1 504 322 non‐exposed subjects were included, among whom there were 141 and 1972 cases of (autoimmune) thyroiditis; 2 and 2 cases of GBS; and 43 and 401 cases of IBD, respectively. In the case‐control study, there were 97 cases of AIT and 13 of GBS; matched with 802 and 130 controls, respectively. The primary analysis OR estimates were 1.46 (95% confidence interval [CI] 1.22‐1.76), 11.14 (2.00‐61.92), and 1.11 (0.75‐1.66) for (autoimmune) thyroiditis, GBS, and IBD, respectively.ConclusionsThis meta‐analysis did not show an increased risk of IBD following vaccination with AS04‐HPV‐16/18. The 1.5‐fold increased risk of (autoimmune) thyroiditis does not allow us to conclude about a causal association. For GBS, the very low number of cases and wide 95% CIs negate any firm conclusion.
Clinical evaluation of cochlear implantation in children younger than 12 months of age
Authors: Yang Yang , Chen Min , Zheng Jun , Hao Jinsheng , Liu Bing , Liu Wei , Li Bei , Shao Jianbo , Liu Haihong , Ni Xin , Zhang Jie 
Published: June 2020

ABSTRACTImportanceCochlear implantation (CI) is an effective therapy for patients with severe to profound sensorineural hearing loss. It remains controversial whether children younger than 12 months of age should undergo CI.ObjectiveTo evaluate the safety and effectiveness of CI in children younger than 12 months of age.MethodsWe performed a retrospective study of clinical data of pediatric patients younger than 12 months of age who underwent CI and were followed up for 1 to 2 years. Patients’ developmental levels were evaluated by the Gesell score before CI. Intraoperative and postoperative complications were recorded to evaluate the safety of CI. Auditory and speech abilities were scored by the LittlEARS® auditory questionnaire (LEAQ), categories of auditory performance (CAP), speech intelligibility rating (SIR), infant‐toddler meaningful auditory integration scale (IT‐MAIS), and meaningful use of speech scale (MUSS) at 1, 2, 3, 6, 9, and 12 months after CI. The associations between clinical characteristics before CI and postoperative scores at 1 year after CI were analyzed by the linear mixed‐effects model.ResultsEighty‐nine children (47 boys and 42 girls) were included in this study (mean age at CI, 9.2 ± 1.6 months). Sixteen patients were diagnosed with cochlear malformation and 16 underwent bilateral CI. No severe complications occurred in any patients. The mean developmental quotient of the Gesell score was 78.00 ± 10.03. The median LEAQ scores were 0, 5, 10, 16, 22, 26 and 30 before and at 1, 2, 3, 6, 9, and 12 months after CI, respectively. These findings implied that the LEAQ score greatly improved in the first year after CI. The overall CAP, SIR, IT‐MAIS, and MUSS scores also increased with increasing duration after CI. No significant associations were detected between clinical characteristics (age, sex, implant number, pre‐CI Gesell score, and inner ear malformation) and LEAQ outcomes at 12 months after CI.InterpretationWith increasing duration after CI, auditory and speech behavior dramatically improve in young children. Our findings indicate that CI is feasible for children younger than 12 months of age.
Characterization of T‐DM1‐resistant breast cancer cells
Authors: Sauveur Juliette , Conilh Louise , Beaumel Sabine , Chettab Kamel , Jordheim Lars‐Petter , Matera Eva‐Laure , Dumontet Charles 
Published: June 2020

AbstractThe development of targeted therapies has drastically improved the outcome of patients with different types of cancer. T‐DM1 (trastuzumab‐emtansine) is an antibody‐drug conjugate used for the treatment of HER2‐positive breast cancer combining the FDA approved mAb (monoclonal antibody) trastuzumab and the microtubule cytotoxic agent DM1 (emtansine). Despite clinical successes achieved by targeted therapies, a large number of patients develop resistance during treatment. To explore mechanisms of resistance to T‐DM1, the MDA‐MB‐361 HER2‐positive breast cancer cell line was exposed in vitro to T‐DM1 in the absence or presence of ciclosporin A. Previously reported mechanisms of resistance such as trastuzumab‐binding alterations, MDR1 upregulation, and SLC46A3 downregulation were not observed in these models. Despite a decrease in HER2 expression at the cell surface, both resistant cell lines remained sensitive to HER2 targeted therapies such as mAbs and tyrosine kinase inhibitors. In addition, sensitivity to DNA damaging agents and topoisomerase inhibitors were unchanged. Conversely resistance to anti‐tubulin agents increased. Resistant cells displayed a decreased content of polymerized tubulin and a decreased content of βIII tubulin although the downregulation of βIII tubulin by siRNA in the parental cell line did not modified the sensitivity to T‐DM1. Both cell lines resistant to T‐DM1 also presented giant aneuploid cells. Several SLC (solute carrier) transporters were found to be differentially expressed in the resistant cells in comparison to parental cells. These results suggest that some characteristics such as increased baseline aneuploidy and altered intracellular drug trafficking might be involved in resistance to T‐DM1.
Low‐energy Sr2MSbO5.5 (M = Ca and Sr) structures show significant distortions near oxygen vacancies
Authors: Patel Megha , Zhong Jiayun , Gomez‐Haibach Konrad S. , Gomez Maria A. , King Graham 
Published: June 2020

AbstractInspired by significant local distortions found near vacancies in a neutron pair distribution function analysis study (G. King et al., Inorg. Chem. 2012, 51, 13060) of Sr2MSbO5.5 (M = Ca and Sr), this computational study finds minimum‐energy structures with these and related distortions using density functional theory (DFT) with the Perdew‐Burke‐Ernzerhof (PBE) functional as implemented in the Vienna Ab Initio Simulations Package (VASP) (G. Kresse and J. Furthmüller, Phys. Rev. B, 1996, 54, 11169; G. Kresse and J. Hafner, Phys. Rev. B, 1993, 47, 558; G. Kresse and J. Furthmüller, Comput. Mater. Sci., 1996, 6, 15). All structures were optimized using the conjugate gradient method. The global minima found for both systems featured trigonal bipyramid SbO5 structures and edge sharing with M‐centered polyhedra. However, while calcium ions occupied full and partial octahedra, the larger strontium ions were more commonly found in full and partial pentagonal bipyramids. Molecular dynamics with velocity rescaling at 1200 K revealed movements of the oxygen vacancy via polyhedral rotations. This work highlights the need to consider both square pyramid to trigonal bipyramid rearrangements around small ions and rotational polyhedral movements in simulating oxygen vacancy conduction in oxygen‐deficient double perovskites.
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
Authors: Chambers Daniel C. , Lutzky Viviana P. , Apte Simon H. , Godbolt David , Feenstra John , Mackintosh John 
Published: June 2020

AbstractWe report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the hair, the peripheral blood monocyte telomere length was measured and was confirmed to be <1st centile, explaining the multiorgan presentation. She was treated with prednisolone, mycophenolate mofetil, and the synthetic androgen danazol with a dramatic improvement in respiratory failure and lung function. After 18 months of danazol treatment, the peripheral blood monocyte telomere length had returned to the normal range.
2D Metal–Organic Frameworks (MOFs) for High‐Performance BatCap Hybrid Devices
Authors: Wang Kuaibing , Li Qingqing , Ren Zhujuan , Li Chao , Chu Yang , Wang Zikai , Zhang Mingdao , Wu Hua , Zhang Qichun 
Published: June 2020

AbstractTwo identical layered metal–organic frameworks (MOFs) (CoFRS and NiFRS) are constructed by using flexible 1,10‐bis(1,2,4‐triazol‐1‐yl)decane as pillars and 1,4‐benzenedicarboxylic acid as rigid linkers. The single‐crystal structure analysis indicates that the as‐synthesized MOFs possess fluctuant 2D networks with large interlayer lattices. Serving as active electrode elements in supercapacitors, both MOFs deliver excellent rate capabilities, high capacities, and longstanding endurances. Moreover, the new intermediates in two electrodes before and after long‐lifespan cycling are also examined, which cannot be identified as metal hydroxides in the peer reports. After assembled into battery‐supercapacitor (BatCap) hybrid devices, the NiFRS//activated carbon (AC) device displays better electrochemical results in terms of gravimetric capacitance and cycling performance than CoFRS//AC devices, and a higher energy‐density value of 28.7 Wh kg−1 compared to other peer references with MOFs‐based electrodes. Furthermore, the possible factors to support the distinct performances are discussed and analyzed.
Passerelle Bahnhof Rotkreuz
Authors: Lüthi Thomas , Dubs Rafael 
Published: June 2020

AbstractDie Personenüberführung Rotkreuz Ost verbindet die Bahnsteige des Bahnhofs Rotkreuz mit den angrenzenden Quartieren und wurde im September 2019 nach neun Monaten Bauzeit eröffnet. Das ausgeführte Stahlbrückenprojekt ging in einem Wettbewerb mit Präqualifikation als Sieger hervor. Die knapp 100 m lange Fußgängerpasserelle mit vier Liften und Treppenabgängen überbrückt das Gleisfeld als Zweifeldträger. Das Tragwerk besteht aus einem Hohlkasten mit auskragender Fahrbahn und ist mittels dreier Stützen im Baugrund eingespannt.Gestalterisch wurde ein schlichtes, modernes Erscheinungsbild angestrebt. Der Stahlhohlkasten auf der Rückseite der Brücke erzeugt eine geschlossene Fläche, während der gegenüberliegende Rand mit einem transparenten Metallgeflecht abgeschlossen ist. Das gestalterische Konzept mit einer geschlossenen Seite und transparenter Gegenseite ist auf den Treppenabgängen am Brückenrand nahtlos fortgeführt und erzeugt so ein einheitliches Gesamtbild.
A Mixture of Modified Starch and Maltodextrin for Spray Drying Encapsulation of Nigella sativa Seeds Oil Containing Thymoquinone
Authors: Abedi Abdol‐Samad , Rismanchi Marjan , Moosavi Motahareh Hashemi , Khaneghah Amin Mousavi , Mohammadi Abdorreza , Mahmoudzadeh Maryam 
Published: June 2020

AbstractThymoquinone (TQ), a monoterpenoid quinone, is a major bioactive component of Nigella sativa L. seeds oil, which has been proven to have therapeutic and bioactive properties. The current study is carried out to investigate the encapsulation of N. sativa seeds oil containing TQ using the mixture of modified starch (MS) and maltodextrin (MD). In this regard, the effect of the different ratios of MS:MD on encapsulation efficiency (EE), TQ retention, and other characteristics of particles is investigated. The highest EE is observed in particles with 80:20 ratio of MS:MD powders achieving more than 90%, while the sample with 50:50 ratio of the wall materials has the maximum value of the retention of TQ (61.12%). The increase of MD ratio in formulations improves the wettability (<3 min) and solubility (>90%) of the particles, decreases the moisture up to 0.08%, and decreases the EE and TQ retention till 80% and 55%, respectively. The particles prepared with 50:50 ratio of MS:MD are the best particles with acceptable EE and better TQ retention is selected to evaluate the stability of TQ during the time. Results show that the encapsulation of N. sativa seeds oil considerably prevents the degradation of TQ during storage.