bluuebunny/crossref_metadata_2025_split huggingface dataset:
(So) Big Data and the transformation of the city
Authors: Andrienko Gennady , Andrienko Natalia , Boldrini Chiara , Caldarelli Guido , Cintia Paolo , Cresci Stefano , Facchini Angelo , Giannotti Fosca , Gionis Aristides , Guidotti Riccardo , Mathioudakis Michael , Muntean Cristina Ioana , Pappalardo Luca , Pedreschi Dino , Pournaras Evangelos , Pratesi Francesca , Tesconi Maurizio , Trasarti Roberto 
Published: March 2020

AbstractThe exponential increase in the availability of large-scale mobility data has fueled the vision of smart cities that will transform our lives. The truth is that we have just scratched the surface of the research challenges that should be tackled in order to make this vision a reality. Consequently, there is an increasing interest among different research communities (ranging from civil engineering to computer science) and industrial stakeholders in building knowledge discovery pipelines over such data sources. At the same time, this widespread data availability also raises privacy issues that must be considered by both industrial and academic stakeholders. In this paper, we provide a wide perspective on the role that big data have in reshaping cities. The paper covers the main aspects of urban data analytics, focusing on privacy issues, algorithms, applications and services, and georeferenced data from social media. In discussing these aspects, we leverage, as concrete examples and case studies of urban data science tools, the results obtained in the “City of Citizens” thematic area of the Horizon 2020 SoBigData initiative, which includes a virtual research environment with mobility datasets and urban analytics methods developed by several institutions around Europe. We conclude the paper outlining the main research challenges that urban data science has yet to address in order to help make the smart city vision a reality.
Monthly Distribution of 1933 Famine Losses in Soviet Ukraine and the Russian Soviet Republic at the Regional Level
Authors: Wolowyna Oleh , Levchuk Nataliia , Kovbasiuk Alla 
Published: March 2020

AbstractOne of the distinct characteristics of the 1932–1933 famine is that between 65 and 80 percent of all famine-related deaths (direct losses) in rural areas of Soviet Ukraine (UkrSSR) and its oblasts and some regions of the Russian Soviet Federative Socialist Republic (RSFSR) occurred during the first six or seven months of 1933, and that in all oblasts of UkrSSR and some regions of RSFSR the number of famine losses increased by a factor of six to 15 between January and June–July of 1933. The historical explanation of this sudden explosion of deaths is critically examined, and a more comprehensive explanation is proposed. We show that the regional variations in these increases in losses are correlated with four factors: extensive household searches for grain with all food taken away in many instances, closing of inter-republic borders and limitation of internal travel by peasants, resistance to collectivization and grain requisitions and repressions, and the “nationality factor.” Analysis of the monthly dynamics of rural losses during the first half of 1933 suggests a possible independent confirmation of the hypothesis that during the searches for “hidden” or “stolen” grain, all food was taken away in many households.
Precision and personalized assessment, diagnosis and treatment in psychiatry
Authors: Fountoulakis Konstantinos N. , Stahl Stephen M. 
Published: March 2020

Abstract“Precision medicine” and “personalized medicine” constitute goals of research since antiquity and this was intensified with the arrival of the “evidence-based medicine.” precision and personalized psychiatry (3P) when achieved will constitute a radical shift in our paradigm and it will be even more transformative than in other fields of medicine. The biggest problems so far are the problematic definition of mental disorder, available treatments seem to concern broad categories rather than specific disorders and finally clinical predictors of treatment response or side effects and biological markers do not exist. Precision and personalized psychiatry like all precision medicine will be a laborious and costly task; thus the partnership of scientists with industry and the commercialization of new methods and technologies will be an important element for success. The development of an appropriate legal framework which will both support development and progress but also will protect the rights and the privacy of patients and their families is essential.
COVID-19 disease emergency operational instructions for Mental Health Departments issued by the Italian Society of Epidemiological Psychiatry
Authors: Starace Fabrizio , Ferrara Maria 
Published: March 2020

Abstract
During the current COVID-19 disease emergency, it is not only an ethical imperative but also a public health responsibility to keep the network of community psychiatry services operational, particularly for the most vulnerable subjects (those with mental illness, disability, and chronic conditions). At the same time, it is necessary to reduce the spread of the COVID-19 disease within the outpatient and inpatient services affiliated with Mental Health Departments. These instructions, first published online on 16 March 2020 in their original Italian version, provide a detailed description of actions, proposed by the Italian Society of Epidemiological Psychiatry, addressed to Italian Mental Health Departments during the current COVID-19 pandemic. The overall goal of the operational instructions is to guarantee, during the current health emergency, the provision of the best health care possible, taking into account both public health necessities and the safety of procedures. These instructions could represent a useful resource to mental health providers, and stakeholders to face the current pandemic for which most of Mental Health Departments worldwide are not prepared to. These instructions could provide guidance and offer practical tools which can enable professionals and decision makers to foresee challenges, like those already experienced in Italy, which in part can be avoided or minimised if timely planned. These strategies can be shared and adopted, with the appropriate adjustments, by Mental Health Departments in other countries.
Strong Variability of Martian Water Ice Clouds During Dust Storms Revealed From ExoMars Trace Gas Orbiter/NOMAD
Authors: Liuzzi Giuliano , Villanueva Geronimo L. , Crismani Matteo M.J. , Smith Michael D. , Mumma Michael J. , Daerden Frank , Aoki Shohei , Vandaele Ann Carine , Clancy R. Todd , Erwin Justin , Thomas Ian , Ristic Bojan , Lopez‐Moreno José‐Juan , Bellucci Giancarlo , Patel Manish R. 
Published: March 2020

AbstractObservations of water ice clouds and aerosols on Mars can provide important insights into the complexity of the water cycle. Recent observations have indicated an important link between dust activity and the water cycle, as intense dust activity can significantly raise the hygropause, and subsequently increase the escape of water after dissociation in the upper atmosphere. Here present observations from Nadir and Occultation for MArs Discovery/Trace Gas Orbiter that investigate the variation of water ice clouds in the perihelion season of Mars year 34 (April 2018–2019), their diurnal and seasonal behavior, and the vertical structure and microphysical properties of water ice and dust. These observations reveal the recurrent presence of a layer of mesospheric water ice clouds subsequent to the 2018 global dust storm. We show that this layer rose from 45 to 80 km in altitude on a time scale of days from heating in the lower atmosphere due to the storm. In addition, we demonstrate that there is a strong dawn‐dusk asymmetry in water ice abundance, related to nighttime nucleation and subsequent daytime sublimation. Water ice particle sizes are retrieved consistently and exhibit sharp vertical gradients (from 0.1 to 4.0 μm), as well as mesospheric differences between the global dust storm (<0.5 μm) and the 2019 regional dust storm (1.0 μm), which suggests differing water ice nucleation efficiencies. These results form the basis to advance our understanding of mesospheric water ice clouds on Mars, and further constrain the interactions between water ice and dust in the middle atmosphere.
Elevated intracellular copper contributes a unique role to kidney fibrosis by lysyl oxidase mediated matrix crosslinking
Authors: Niu Yang-yang , Zhang Ying-ying , Zhu Zhi , Zhang Xiao-qin , Liu Xi , Zhu Sai-ya , Song Ye , Jin Xian , Lindholm Bengt , Yu Chen 
Published: March 2020

AbstractCopper ions play various roles in mammalian cells, presumably due to their involvement in different enzymatic reactions. Some studies indicated that serum copper correlates with fibrosis in organs, such as liver and lung. However, the mechanism is unknown. Here, we explored the role of copper in kidney fibrosis development and possible underlying mechanisms. We found that copper transporter 1 (CTR1) expression was increased in the kidney tissues in two fibrosis models and in patients with kidney fibrosis. Similar results were also found in renal tubular epithelial cells and fibroblast cells treated with transforming growth factor beta (TGF-β). Mechanistically, the upregulation of CTR1 required Smads-dependent TGF-β signaling pathway and Smad3 directly binded to the promoter of CTR1 in renal fibroblast cells using chromatin immunoprecipitation. Elevated CTR1 induced increase of copper intracellular influx. The elevated intracellular copper ions activated lysyl oxidase (LOX) to enhance the crosslinking of collagen and elastin, which then promoted kidney fibrosis. Reducing intracellular copper accumulation by knocking down CTR1 ameliorated kidney fibrosis in unilateral ureteral obstruction induced renal fibrosis model and renal fibroblast cells stimulated by TGF-β. Treatment with copper chelator tetrathiomolybdate (TM) also alleviated renal fibrosis in vivo and in vitro. In conclusion, intracellular copper accumulation plays a unique role to kidney fibrosis by activating LOX mediated collagen and elastin crosslinking. Inhibition of intracellular copper overload may be a potential portal to alleviate kidney fibrosis.
Pelagic fish predation is stronger at temperate latitudes than near the equator
Authors: Roesti Marius , Anstett Daniel N. , Freeman Benjamin G. , Lee-Yaw Julie A. , Schluter Dolph , Chavarie Louise , Rolland Jonathan , Holzman Roi 
Published: March 2020

AbstractSpecies interactions are widely thought to be strongest in the tropics, potentially contributing to the greater number of species at lower latitudes. Yet, empirical tests of this “biotic interactions” hypothesis remain limited and often provide mixed results. Here, we analyze 55 years of catch per unit effort data from pelagic longline fisheries to estimate the strength of predation exerted by large predatory fish in the world’s oceans. We test two central tenets of the biotic interactions hypothesis: that predation is (1) strongest near the equator, and (2) positively correlated with species richness. Counter to these predictions, we find that predation is (1) strongest in or near the temperate zone and (2) negatively correlated with oceanic fish species richness. These patterns suggest that, at least for pelagic fish predation, common assumptions about the latitudinal distribution of species interactions do not apply, thereby challenging a leading explanation for the latitudinal gradient in species diversity.
Synergistic ultraviolet and visible light photo-activation enables intensified low-temperature methanol synthesis over copper/zinc oxide/alumina
Authors: Xie Bingqiao , Wong Roong Jien , Tan Tze Hao , Higham Michael , Gibson Emma K. , Decarolis Donato , Callison June , Aguey-Zinsou Kondo-Francois , Bowker Michael , Catlow C. Richard A. , Scott Jason , Amal Rose 
Published: March 2020

AbstractAlthough photoexcitation has been employed to unlock the low-temperature equilibrium regimes of thermal catalysis, mechanism underlining potential interplay between electron excitations and surface chemical processes remains elusive. Here, we report an associative zinc oxide band-gap excitation and copper plasmonic excitation that can cooperatively promote methanol-production at the copper-zinc oxide interfacial perimeter of copper/zinc oxide/alumina (CZA) catalyst. Conversely, selective excitation of individual components only leads to the promotion of carbon monoxide production. Accompanied by the variation in surface copper oxidation state and local electronic structure of zinc, electrons originating from the zinc oxide excitation and copper plasmonic excitation serve to activate surface adsorbates, catalysing key elementary processes (namely formate conversion and hydrogen molecule activation), thus providing one explanation for the observed photothermal activity. These observations give valuable insights into the key elementary processes occurring on the surface of the CZA catalyst under light-heat dual activation.
Macroscopic conductivity of aqueous electrolyte solutions scales with ultrafast microscopic ion motions
Authors: Balos Vasileios , Imoto Sho , Netz Roland R. , Bonn Mischa , Bonthuis Douwe Jan , Nagata Yuki , Hunger Johannes 
Published: March 2020

AbstractDespite the widespread use of aqueous electrolytes as conductors, the molecular mechanism of ionic conductivity at moderate to high electrolyte concentrations remains largely unresolved. Using a combination of dielectric spectroscopy and molecular dynamics simulations, we show that the absorption of electrolytes at ~0.3 THz sensitively reports on the local environment of ions. The magnitude of these high-frequency ionic motions scales linearly with conductivity for a wide range of ions and concentrations. This scaling is rationalized within a harmonic oscillator model based on the potential of mean force extracted from simulations. Our results thus suggest that long-ranged ionic transport is intimately related to the local energy landscape and to the friction for short-ranged ion dynamics: a high macroscopic electrolyte conductivity is thereby shown to be related to large-amplitude motions at a molecular scale.
Metagenome-wide association of gut microbiome features for schizophrenia
Authors: Zhu Feng , Ju Yanmei , Wang Wei , Wang Qi , Guo Ruijin , Ma Qingyan , Sun Qiang , Fan Yajuan , Xie Yuying , Yang Zai , Jie Zhuye , Zhao Binbin , Xiao Liang , Yang Lin , Zhang Tao , Feng Junqin , Guo Liyang , He Xiaoyan , Chen Yunchun , Chen Ce , Gao Chengge , Xu Xun , Yang Huanming , Wang Jian , Dang Yonghui , Madsen Lise , Brix Susanne , Kristiansen Karsten , Jia Huijue , Ma Xiancang 
Published: March 2020

AbstractEvidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.
Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway
Authors: Iervolino Anna , Prosperi Federica , De La Motte Luigi R. , Petrillo Federica , Spagnuolo Manuela , D’Acierno Mariavittoria , Siccardi Sabrina , Perna Alessandra F. , Christensen Birgitte M. , Frische Sebastian , Capasso Giovambattista , Trepiccione Francesco 
Published: March 2020

AbstractPotassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. The intercalated cells acquired a novel distribution pattern forming rows of cells attached to each other. These morphological changes occur progressively and reverse after 7 days of recovery on normal rat chow diet. The cellular remodeling mainly occurred in the inner stripe of outer medulla similar to the previously seen effect of lithium on the collecting duct cellular profile. The cellular remodeling is associated with the appearance of cells double labelled with both specific markers of principal and type-A intercalated cells. The appearance of this cell type was associated with the downregulation of the Notch signaling via the Hes1 pathways. These results show that the epithelium of the collecting duct has a high degree of plasticity and that Notch signaling likely plays a key role during hypokalemia.
Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney
Authors: Poulaki Elpida , Detsika Maria G. , Fourtziala Eythimia , Lianos Elias A. , Gakiopoulou Hariklia 
Published: March 2020

AbstractAlthough Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms include podocyte (visceral glomerular epithelial cell/GEC) injury. To assess whether HO-1 can attenuate ageing – related lesions, rats with GEC-targeted HO-1 overexpression (GECHO-1 rats) were generated using a Sleeping Beauty (SB) transposon system and extent of lesions over a 12-month period were assessed and compared to those in age-matched wild-type (WT) controls. GECHO-1 rats older than 6 months developed albuminuria that was detectable at 6 months and became significantly higher compared to age-matched WT controls at 12 months. In GECHO-1 rats, lesions of focal segmental and global glomerulosclerosis as well as tubulointerstitial lesions were prominent while podocytes were edematous with areas of foot process effacement and glomerular basement membrane thickening and wrinkling. GECHO-1 rats also developed hemoglobinuria and hemosiderinuria associated with marked tubular hemosiderin deposition and HO-1 induction, while there was depletion of splenic iron stores. Kidney injury was of sufficient magnitude to increase serum lactate dehydrogenase (LDH) and was oxidative in nature as shown by increased expression of 8-hydroxydeoxyguanosine (8-OHdg, a byproduct of oxidative DNA damage) in podocytes and tubular epithelial cells. These observations highlight a detrimental effect of podocyte-targeted HO-1 overexpression on ageing-related renal pathology and point to increased renal iron deposition as a putative underlying mechanism.
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK
Authors: Zieger Hanna L. , Kunde Stella-Amrei , Rademacher Nils , Schmerl Bettina , Shoichet Sarah A. 
Published: March 2020

AbstractScaffold proteins are responsible for structural organisation within cells; they form complexes with other proteins to facilitate signalling pathways and catalytic reactions. The scaffold protein connector enhancer of kinase suppressor of Ras 2 (CNK2) is predominantly expressed in neural tissues and was recently implicated in X-linked intellectual disability (ID). We have investigated the role of CNK2 in neurons in order to contribute to our understanding of how CNK2 alterations might cause developmental defects, and we have elucidated a functional role for CNK2 in the molecular processes that govern morphology of the postsynaptic density (PSD). We have also identified novel CNK2 interaction partners and explored their functional interdependency with CNK2. We focussed on the novel interaction partner TRAF2- and NCK-interacting kinase TNIK, which is also associated with ID. Both CNK2 and TNIK are expressed in neuronal dendrites and concentrated in dendritic spines, and staining with synaptic markers indicates a clear postsynaptic localisation. Importantly, our data highlight that CNK2 plays a role in directing TNIK subcellular localisation, and in neurons, CNK2 participates in ensuring that this multifunctional kinase is present in the correct place at desirable levels. In summary, our data indicate that CNK2 expression is critical for modulating PSD morphology; moreover, our study highlights that CNK2 functions as a scaffold with the potential to direct the localisation of regulatory proteins within the cell. Importantly, we describe a novel link between CNK2 and the regulatory kinase TNIK, and provide evidence supporting the idea that alterations in CNK2 localisation and expression have the potential to influence the behaviour of TNIK and other important regulatory molecules in neurons.
Automatic mandibular canal detection using a deep convolutional neural network
Authors: Kwak Gloria Hyunjung , Kwak Eun-Jung , Song Jae Min , Park Hae Ryoun , Jung Yun-Hoa , Cho Bong-Hae , Hui Pan , Hwang Jae Joon 
Published: March 2020

AbstractThe practicability of deep learning techniques has been demonstrated by their successful implementation in varied fields, including diagnostic imaging for clinicians. In accordance with the increasing demands in the healthcare industry, techniques for automatic prediction and detection are being widely researched. Particularly in dentistry, for various reasons, automated mandibular canal detection has become highly desirable. The positioning of the inferior alveolar nerve (IAN), which is one of the major structures in the mandible, is crucial to prevent nerve injury during surgical procedures. However, automatic segmentation using Cone beam computed tomography (CBCT) poses certain difficulties, such as the complex appearance of the human skull, limited number of datasets, unclear edges, and noisy images. Using work-in-progress automation software, experiments were conducted with models based on 2D SegNet, 2D and 3D U-Nets as preliminary research for a dental segmentation automation tool. The 2D U-Net with adjacent images demonstrates higher global accuracy of 0.82 than naïve U-Net variants. The 2D SegNet showed the second highest global accuracy of 0.96, and the 3D U-Net showed the best global accuracy of 0.99. The automated canal detection system through deep learning will contribute significantly to efficient treatment planning and to reducing patients’ discomfort by a dentist. This study will be a preliminary report and an opportunity to explore the application of deep learning to other dental fields.