bluuebunny/crossref_metadata_2025_split huggingface dataset:
The newly discovered Be/X-ray binary Swift J004516.6–734703 in the SMC: witnessing the emergence of a circumstellar disc
Authors: Kennea J A , Coe M J , Evans P A , Monageng I M , Townsend L J , Siegel M H , Udalski A , Buckley D A H 
Published: September 2020

ABSTRACT
We report on the discovery of Swift J004516.6–734703, a Be/X-ray binary system by the Swift SMC Survey, S-CUBED. Swift J004516.6–734703, or SXP 146.6, was found to be exhibiting a bright (∼1037 erg s−1) X-ray outburst on 2020 June 18. The historical UV and IR light-curves from OGLE and Swift/UVOT showed that after a long period of steady brightness, it experienced a significant brightening beginning around 2019 March. This IR/UV rise is likely the signature of the formation of a circumstellar disc, confirmed by the presence of strong an H α line in SALT spectroscopy, that was not previously present. Periodicity analysis of the OGLE data reveals a plausible 426 d binary period, and in X-ray a pulsation period of 146.6 s is detected. The onset of X-ray emission from Swift J004516.6–734703 is likely the signature of a Type-I outburst from the first periastron passage of the neutron star companion through the newly formed circumstellar disc. We note that the formation of the circumstellar disc began at the predicted time of the previous periastron passage, suggesting its formation was spurred by tidal interaction with the neutron star.
Genome Duplication Increases Meiotic Recombination Frequency: A Saccharomyces cerevisiae Model
Authors: Fang Ou , Wang Lin , Zhang Yuxin , Yang Jixuan , Tao Qin , Zhang Fengjun , Luo Zewei 
Published: September 2020

Abstract
Genetic recombination characterized by reciprocal exchange of genes on paired homologous chromosomes is the most prominent event in meiosis of almost all sexually reproductive organisms. It contributes to genome stability by ensuring the balanced segregation of paired homologs in meiosis, and it is also the major driving factor in generating genetic variation for natural and artificial selection. Meiotic recombination is subjected to the control of a highly stringent and complex regulating process and meiotic recombination frequency (MRF) may be affected by biological and abiotic factors such as sex, gene density, nucleotide content, and chemical/temperature treatments, having motivated tremendous researches for artificially manipulating MRF. Whether genome polyploidization would lead to a significant change in MRF has attracted both historical and recent research interests; however, tackling this fundamental question is methodologically challenging due to the lack of appropriate methods for tetrasomic genetic analysis, thus has led to controversial conclusions in the literature. This article presents a comprehensive and rigorous survey of genome duplication-mediated change in MRF using Saccharomyces cerevisiae as a eukaryotic model. It demonstrates that genome duplication can lead to consistently significant increase in MRF and rate of crossovers across all 16 chromosomes of S. cerevisiae, including both cold and hot spots of MRF. This ploidy-driven change in MRF is associated with weakened recombination interference, enhanced double-strand break density, and loosened chromatin histone occupation. The study illuminates a significant evolutionary feature of genome duplication and opens an opportunity to accelerate response to artificial and natural selection through polyploidization.
Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
Authors: Belorusova Anna Y , Bourguet Maxime , Hessmann Steve , Chalhoub Sandra , Kieffer Bruno , Cianférani Sarah , Rochel Natacha 
Published: September 2020

AbstractThe MED1 subunit of the Mediator complex is an essential coactivator of nuclear receptor-mediated transcriptional activation. While structural requirements for ligand-dependent binding of classical coactivator motifs of MED1 to numerous nuclear receptor ligand-binding domains have been fully elucidated, the recognition of the full-length or truncated coactivator by full nuclear receptor complexes remain unknown. Here we present structural details of the interaction between a large part of MED1 comprising its structured N-terminal and the flexible receptor-interacting domains and the mutual heterodimer of the vitamin D receptor (VDR) and the retinoid X receptor (RXR) bound to their cognate DNA response element. Using a combination of structural and biophysical methods we show that the ligand-dependent interaction between VDR and the second coactivator motif of MED1 is crucial for complex formation and we identify additional, previously unseen, interaction details. In particular, we identified RXR regions involved in the interaction with the structured N-terminal domain of MED1, as well as VDR regions outside the classical coactivator binding cleft affected by coactivator recruitment. These findings highlight important roles of each receptor within the heterodimer in selective recognition of MED1 and contribute to our understanding of the nuclear receptor-coregulator complexes.
A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2019
Authors: Stover Kayla R , Chahine Elias B , Cluck David , Green Sarah , Chastain Daniel B , Childress Darrell , Faulkner-Fennell Carmen , Lusardi Katherine , McGee Edoabasi U , Turner Michelle , Bookstaver P Brandon , Bland Christopher M 
Published: September 2020

Abstract
Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship–related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training and to identify potential intervention opportunities within one’s institution.
Jasmonic Acid- and Ethylene-Induced Mitochondrial Alternative Oxidase Stimulates Marssonina brunnea Defense in Poplar
Authors: Liao Yangwenke , Cui Rongrong , Xu Xin , Cheng Qiang , Li Xiaogang 
Published: September 2020

Abstract
Mitochondrial processes are implicated in plant response to biotic stress caused by viruses, actinomyces, bacteria and pests, but their function in defense against fungal invasion remains unclear. Here, we investigated the role and regulation of mitochondrial alternative oxidase (AOX) in response to black spot disease caused by the hemibiotrophic fungus Marssonina brunnea in poplar. M. brunnea inoculation induced the transcription of the AOX1a gene in the mitochondrial electron transport chain and of jasmonic acid (JA) and ethylene (ET) biosynthetic genes, with the accumulation of these phytohormones in poplar leaf, while inhibiting the transcript amount of the mitochondrial cytochrome c oxidase gene (COX6b) and genes related to salicylic acid (SA). Enhanced AOX reduced poplar susceptibility to M. brunnea with a higher ATP/ADP ratio while the repressed AOX caused the reverse effect. Exogenous JA and 1-aminocyclopropane-1-carboxylic acid (ACC, a biosynthetic precursor of ET) inhibited the transcript amount of COX6b and consequently increased the ratio of AOX pathway to total respiration. Furthermore, the transcription of CYS C1 and CYS D1 genes catalyzing cyanide metabolism was induced, while the cysteine (CYS) substrate levels reduced upon M. brunnea inoculation; exogenous JA and ACC mimicked the effect of M. brunnea infection on cysteine. Exogenous SA enhanced, while JA and ACC reduced, poplar susceptibility to M. brunnea. Moreover, inhibiting AOX completely prohibited JA- and ET-increased tolerance to M. brunnea in poplar. These observations indicate that the JA- and ET-induced mitochondrial AOX pathway triggers defense against M. brunnea in poplar. This effect probably involves cyanide. These findings deepen our understanding of plant–pathogenic fungi interactions.
Size-mediated temperature effect on embryonic development in Eodiaptomus japonicus (Copepoda, Calanoida) in Lake Biwa, Japan
Authors: Liu Xin , Ban Syuhei 
Published: September 2020

Abstract
Egg size has numerous ecological implications for zooplankton, and can influence hatching duration and female fecundity. In this study, temperature functions of embryonic development time (EDT) were determined in the copepod Eodiaptomus japonicus from Lake Biwa, in the cold and warm seasons, to clarify synergistic effects of egg size and temperature on EDT. EDT was longer for cold season eggs than warm ones, but both seasons were well fitted by Bĕlehrádek’s function. Egg size was significantly correlated with female body size within seasons, but the relationship did not differ significantly between seasons. These results suggest that seasonal variation in EDT, which was associated with egg size, may result from temperature-mediated variation of female body size, because larger females produced larger eggs as temperature decreased. Larger eggs may enhance fitness under severe food conditions in winter due to high hatchability and naupliar survival.
Exploring Patient Perceptions of Opioid Treatment Agreements in a Community Health Center Environment
Authors: Irwin Adriane N , Braden-Suchy Natalea , Hartung Daniel M 
Published: September 2020

Abstract

Objective
Describe patient attitudes toward opioid treatment agreements (OTAs) and characterize perceptions of their impact on patient care, behavior, communication with prescribers, and engagement with the health care system.

Design
Qualitative descriptive study.

Setting
Federally qualified health center with six clinic locations serving a rural population.

Subjects
Patients were prescribed long-term opioid therapy and were required to sign an OTA through an in-person office visit with a clinical pharmacist.

Methods
Patients who signed an OTA were recruited to participate in semistructured, in-person, one-on-one interviews. Data were analyzed using immersion-crystallization methods.

Results
Among the 20 patients recruited, 50% were men; 70% were insured by the state’s Medicaid program; and 85% were using opioids for hip, back, and/or neck pain. Four major themes arose from the interviews. First, individuals who use long-term opioids experience a wide variety of opioid-related fears and stigmas. Second, individuals articulated real or potential benefits from implementing OTAs. Third, opinions differed on whether OTAs affected behavior and reduced opioid misuse and diversion. Finally, individuals provided feedback on the health care system’s OTA implementation process.

Conclusions
Patients experienced a wide variety of opioid-related fears and stigmas, including how OTA requirements can perpetuate these issues. Despite these feelings, participants articulated real or potential positive outcomes from the use of OTAs, although they were mixed on whether these agreements translated to any behavior changes. If OTAs are to become standard practice, future research is needed to describe the diversity of patient perspectives and experiences with OTAs and to evaluate their effect on patient outcomes.
Integrating Symptoms Into the Diagnostic Criteria for Breast Cancer–Related Lymphedema: Applying Results From a Prospective Surveillance Program
Authors: Brunelle Cheryl L , Roberts Sacha A , Horick Nora K , Gillespie Tessa C , Jacobs Jamie M , Daniell Kayla M , Naoum George E , Taghian Alphonse G 
Published: September 2020

Abstract

Objective
The objectives of this study were to determine whether patients reporting symptoms are more likely to develop lymphedema and to describe the temporal relationship between symptom onset and lymphedema.

Methods
This was a prospective longitudinal cohort study of 647 women treated for breast cancer and screened for lymphedema using arm volume measurements and subjective questionnaires (n = 647; 2284 questionnaires [median 3.5 per patient, range = 1–24]). Primary study outcome was lymphedema (relative volume change ≥10%). The Kaplan–Meier method was used to estimate cumulative lymphedema incidence. Cox proportional hazards models were used to assess the relationship between symptoms, other risk factors, and lymphedema.

Results
A total of 64 patients (9.9%) developed lymphedema. On multivariable analysis, patients reporting increased arm size (hazard ratio = 3.09, 95% CI = 1.62–5.89) were more likely to progress to lymphedema than those who did not report this symptom. Of those who developed lymphedema, 37 (58%) reported an increased arm size a median of 6.1 months before lymphedema onset (range = 68.6 months before to 50.2 months after lymphedema onset).

Conclusion
Patients at risk of lymphedema who report increased arm size might do so prior to lymphedema onset and are at 3 times the risk of lymphedema as patients not reporting this symptom. Even without objective or observable edema, these patients should be followed vigilantly and considered for early intervention. Symptoms should be incorporated into screening and diagnostic criteria for lymphedema.

Impact
This study shows that patients at risk for breast cancer–related lymphedema who report increased arm size should be considered at high risk for progression to lymphedema—even without edema on measurement or clinical examination—and should be followed vigilantly, with consideration of early intervention.

Lay summary
If you are at risk of lymphedema and you feel as though your arm size has increased, you might develop lymphedema, and you are at 3 times the risk of lymphedema as patients not reporting this symptom. Even without measurable or observable edema, you should be followed vigilantly and consider early intervention.
Heterogeneous impacts of research grant funding
Authors: Bloch Carter 
Published: September 2020

Abstract
This paper seeks to examine whether there is heterogeneity in the impacts of research grant funding, by examining whether before–after differences in citation impact are related to the past performance of grantees. Analysis of the heterogeneity in funding impacts can potentially inform the selection of awardees and the design of funding instruments and application and assessment procedures. We examine the impacts of research project grants awarded over the period from 2005 to 2008 from the Danish Council for Independent Research. For the matched sample of grantees and rejected applicants, mean before–after differences are significantly greater for grantees than rejected applicants. However, results are more mixed when comparing overall distributions instead of mean values, where results are either not significant or weakly significant at the 10% level. This suggests that grants lead to strong results for some but are much less for the majority of grantees. The analysis finds indications that citation impact of research grants is positively related to past research performance, thus providing indications of heterogeneity in grant effects. Additional work could be very useful in further exploring possible systematic relationships between other applicant characteristics, such as years of experience as a researcher and overall publication activity, and subsequent impacts.
A Model of Relative Thinking
Authors: Bushong Benjamin , Rabin Matthew , Schwartzstein Joshua 
Published: September 2020

AbstractFixed differences loom smaller when compared to large differences. We propose a model of relative thinking where a person weighs a given change along a consumption dimension by less when it is compared to bigger changes along that dimension. In deterministic settings, the model predicts context effects such as the attraction effect but predicts meaningful bounds on such effects driven by the intrinsic utility for the choices. In risky environments, a person is less likely to sacrifice utility on one dimension to gain utility on another that is made riskier. For example, a person is less likely to exert effort for a fixed monetary return if there is greater overall income uncertainty. We design and run experiments to test basic model predictions and find support for these predictions.
Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome
Authors: Jimenez-Royo Pilar , Bombardieri Michele , Ciurtin Coziana , Kostapanos Michalis , Tappuni Anwar R , Jordan Natasha , Saleem Azeem , Fuller Teresa , Port Kathleen , Pontarini Elena , Lucchesi Davide , Janiczek Robert , Galette Paul , Searle Graham , Patel Neel , Kershaw Lucy , Gray Calum , Ratia Nirav , van Maurik André , de Groot Marius , Wisniacki Nicolas , Bergstrom Mats , Tarzi Ruth 
Published: September 2020

Abstract

Objectives
To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-fluorodeoxyglucose (18F-FDG; glucose uptake marker), to assess protein synthesis and inflammation, respectively; multiparametric MRI evaluated salivary gland structural and physiological changes.

Methods
In this imaging/clinical/histology comparative study (GSK study 203818; NCT02899377) patients with pSS and age- and sex-matched healthy volunteers underwent MRI of the salivary glands and 11C-MET PET-CT. Patients also underwent 18F-FDG PET-CT and labial salivary gland biopsies. Clinical and biomarker assessments were performed. Primary endpoints were semi-quantitative parameters of 11C-MET and 18F-FDG uptake in submandibular and parotid salivary glands and quantitative MRI measures of structure and inflammation. Clinical and minor salivary gland histological parameter correlations were explored.

Results
Twelve patients with pSS and 13 healthy volunteers were included. Lower 11C-MET uptake in parotid, submandibular and lacrimal glands, lower submandibular gland volume, higher MRI fat fraction, and lower pure diffusion in parotid and submandibular glands were observed in patients vs healthy volunteer, consistent with reduced synthetic function. Disease duration correlated positively with fat fraction and negatively with 11C-MET and 18F-FDG uptake, consistent with impaired function, inflammation and fatty replacement over time. Lacrimal gland 11C-MET uptake positively correlated with tear flow in patients, and parotid gland 18F-FDG uptake positively correlated with salivary gland CD20+ B-cell infiltration.

Conclusion
Molecular imaging and MRI may be useful tools to non-invasively assess loss of glandular function, increased glandular inflammation and fat accumulation in pSS.
BENCHMARKING THE DOSE MAP SOFTWARE FOR CLINICAL IMPLEMENTATION AND ESTABLISHMENT OF A LOCAL FOLLOW-UP PROTOCOL FOR THE MANAGEMENT OF SKIN INJURES FOLLOWING COMPLEX INTERVENTIONAL CARDIOLOGY PROCEDURES
Authors: Rizk Chadia , Sarkis Antoine , Bejjani Alice , Dabin Jérémie , Farah Jad 
Published: September 2020

Abstract
This paper aims to validate the accuracy of the peak skin dose (Dskin,max) computed by the Dose Map software (DMS)—general electric and establish a local follow-up protocol for the management of patient skin injuries following complex interventional cardiology procedures (ICPs). Dskin,max was computed by the DMS and was simultaneously measured by a dense mesh of 72 thermoluminescent dosemeters for 20 ICP. Measured and computed Dskin,max were compared using Lin’s concordance coefficient (${\rho}_c$). The implementation of a local follow-up strategy was based on a computed Dskin,max of 2 Gy. After eliminating 2 outliers, the average deviation between the two methods was 6% (range: −36 to +40%). Concordance between the two methods was moderate with ${\rho}_c$ (confidence interval) of 0.9128 (0.8541–0.9486). DMS computes Dskin,max with an acceptable accuracy and can be used to setup an individual follow-up process for patients with high skin exposure and risks.
Overlapping certification and technical efficiency of ICT convergence companies in South Korea
Authors: Kim Kyunam , Choe Chung , Lee Daeho 
Published: September 2020

AbstractSince the late 1990s, in South Korea, two innovation certification policies—InnoBiz and Venture certifications—have fostered the innovation activities of venture companies and small- to medium-sized enterprises.The two certifications, however, share similar features in their policy goals, targets, and main content. This study aims to evaluate how technical efficiencies of firms differ based on the types of innovation certifications it achieves and examine the result when a firm simultaneously achieves overlapping certifications. We classified information and communication technology convergence firms into four different groups by certification type and evaluated their performance based on technical efficiency (TE) by applying stochastic frontier analysis and meta-frontier analysis. Our results show that the meta-frontier TE of the group with overlapping certifications is lower than that of the group with a single certification, implying that there is no remarkable performance improvement in terms of the efficiency, particularly when certifications sharing similar characteristics are implemented.
Severe Malnutrition and Anemia Are Associated with Severe COVID in Infants
Authors: Kulkarni Rajesh , Rajput Uday , Dawre Rahul , Sonkawade Naresh , Pawar Sameer , Sonteke Somendra , Varvatte Balaji , Aathira K C , Gadekar Kailas , Varma Santosh , Nakate Leena , Kagal Anju , Kinikar Aarti 
Published: September 2020

ABSTRACT

Background
COVID-19 is uncommon and less severe in children than adults. It is thought that infants may be at higher risk for severe disease than older children. There is a paucity of literature on infants with COVID, particularly those with severe disease.

Objective
We describe demographic, epidemiologic, clinical, radiological, laboratory features and outcomes of infants with confirmed SARS-CoV-2 infection admitted to a tertiary care teaching hospital in Pune, India

Methodology
Infants who tested positive for SARS-CoV-2 and were admitted between 1 April 2020 and 7 August 2020 were included in the study.

Results
A total of 13 infants were admitted during the study period. The median age was 8 months (IQR 6) and nine were male. Common presenting features were fever (n = 8, 62%), poor feeding, irritability, and runny nose (n = 3, 23%). Comorbidities noted were severe acute malnutrition (SAM) in three cases (23%) and nutritional megaloblastic anemia, iron deficiency anemia, sickle thalassemia and renal calculi in one case (8%) each. There was a history of low birth weight in two cases (15%). Pallor was noted in three cases (23%), SAM in three cases (23%) and tachypnea and respiratory distress in four cases (30%). Severe anemia, thrombocytopenia, elevated ferritin, abnormal procalcitonin, abnormal C Reactive Protein and deranged D-dimer was noted in three cases (23%) each. Neutrophil–lymphocyte ratio was normal in all cases. Three infants (43%) had evidence of pneumonia on the chest radiograph, of which one had adult respiratory distress syndrome (ARDS) like pattern, one infant had cardiomegaly and perihilar infiltrates. Hydroxychloroquine and azithromycin were given to five patients (38%), Intravenous Immunoglobulin and methylprednisolone were administered to one patient (8%). One infant died of ARDS with multi-organ dysfunction with refractory shock and hemophagocytic lymphohistiocytosis.

Conclusion
SAM and anemia may be associated with severe COVID in infants.