bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOLECULAR DETERMINANTS OF THE ENDOCYTIC PROTEIN EPSIN CONTROLLING ITS LOCALIZATION AND FUNCTION IN CANCER CELL MIGRATION AND INVASION
Authors: Madhivanan Kayalvizhi , Cao Lingyan , Staiger Chris J. , Aguilar R. Claudio 
Published: July 2020

ABSTRACTEpsins are endocytic adaptor proteins with signaling and endocytic functions. The three mammalian epsin paralogs are made of an Epsin N-Terminal Homology (ENTH) domain and an unstructured C-terminal region. The highly conserved ENTH domain plays a role in signaling by blocking RhoGAP activity and is required for cell migration in mammalian cells. However, our lab has previously shown that only epsin full length overexpression can enhance cell migration, but the ENTH domain alone cannot. Among the three Epsin paralogs, epsin 3 followed by epsin 2 were able to substantially enhance cell migration. This study is the first one to systematically and comprehensibly address the contribution of different motifs within the epsin C-terminus to enhance protein localization and cell migration. We show that is not the lipid-binding ENTH domain, but the C-terminus of epsin the one playing a major role in epsin association with sites of endocytosis. Further, we dissected the contribution of individual C-terminal endocytic (clathrin-, AP2-, Ubiquitin- and EH domain-binding) motifs for epsin localization. We found that while all motifs show a degree of synergism, the clathrin-binding motifs are the most important for epsin localization. Our study also showed that, these motifs (particularly the clathrin binding site) play an important role in sustaining endocytic site dynamics and cell migration.
Zinc Metabolic Defect of Aging Alveolar Progenitors in Progressive Pulmonary Fibrosis
Authors: Liang Jiurong , Huang Guanling , Liu Xue , Taghavifar Forough , Liu Ningshan , Wang Yizhou , Deng Nan , Yao Changfu , Burman Ankita , Xie Ting , Rowan Simon , Weigt S. Samuel , Belperio John , Stripp Barry , Parks William C. , Jiang Dianhua , Noble Paul W. 
Published: July 2020

SUMMARYIdiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease and aging has been identified as a risk factor to the disease. Alveolar type II cells (AEC2s) function as progenitor cells in the lung. Growing evidences indicate that IPF results from repeating AEC2 injury and inadequate epithelial repair. We previously reported that there was a significant loss of alveolar progenitors in the lungs of patients with IPF. In our current study, we performed single cell RNA-seq of epithelial cells from lungs of patients with IPF and healthy donors as well as epithelial cells from old and young mouse lungs with bleomycin injury. We identified a defect of zinc metabolism of AEC2s from IPF lungs and bleomycin-injured old mouse lungs. We further discovered that a specific zinc transporter ZIP8 was down regulated in IPF AEC2s and AEC2s from aged mice. Loss of ZIP8 expression is associated with impaired AEC2 renewal through sirtuin signaling in aging and IPF. Targeted deletion of Zip8 in murine AEC2 compartment led to reduced AEC2 renewal capacity, impaired AEC2 recovery, and worsened lung fibrosis after bleomycin injury. In summary, we have identified novel metabolic defects of AEC2s during aging and in IPF which contribute to the pathogenesis of lung fibrosis. Therapeutic strategies to restore critical components of these metabolic programs could improve AEC2 progenitor activity and mitigate ongoing fibrogenesis.In BriefLiang et al. performed single cell RNA-seq (scRNA-seq) of epithelial cells in IPF and in mice and discovered a zinc metabolic defect of alveolar progenitor cells (AEC2) in IPF and injured old mice characterized by down-regulation of a specific zinc transporter ZIP8. Manipulation of ZIP8 and zinc in 3D organoid culture of AEC2 in vitro and targeted deletion of Zip8 in AEC2s in vivo demonsrated a role of ZIP8 in promoting AEC2 progenitor function.HighlightsScRNA-seq revealed dysregulation of zinc metabolism in AEC2s and decreased stem cell signaling in IPFReducedSLC39A8and related gene expression of IPF AEC2s and aged mouse AEC2sZIP8-dependent zinc metabolism is required for AEC2 renewalTargeted deletion ofSlc39a8impaired AEC2 renewal and promoted lung fibrosis
Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments
Authors: Dutta Anik , Hartmann Fanny E. , Francisco Carolina Sardinha , McDonald Bruce A. , Croll Daniel 
Published: July 2020

AbstractThe adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogenZymoseptoria triticifrom four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used multi-trait genome-wide association mapping. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified numerous pleiotropic SNPs with conflicting effects on host colonization and survival in stressful environments. Such genetic constraints are likely limiting the pathogen’s ability to cause host damage and could be exploited for pathogen control. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations.
Subcellular mRNA localization and local translation ofArhgap11ain radial glial cells regulates cortical development
Authors: Pilaz Louis-Jan , Joshi Kaumudi , Liu Jing , Tsunekawa Yuji , Alsina Fernando C. , Sethi Sahil , Suzuki Ikuo K. , Vanderhaeghen Pierre , Polleux Franck , Silver Debra L. 
Published: July 2020

AbstractmRNA localization and local translation enable exquisite spatial and temporal control of gene expression, particularly in highly polarized and elongated cells. These features are especially prominent in radial glial cells (RGCs), which serve as neural and glial precursors of the developing cerebral cortex, and scaffolds for migrating neurons. Yet the mechanisms by which distinct sub-cellular compartments of RGCs accomplish their diverse functions are poorly understood. Here, we demonstrate that subcellular RNA localization and translation of the RhoGAP Arhgap11a controls RGC morphology and mediates cortical cytoarchitecture.Arhgap11amRNA and protein exhibit conserved localization to RGC basal structures in mice and humans, conferred by a 5′UTR cis-element. Proper RGC morphology relies upon activeArhgap11amRNA transport and localization to basal structures, where ARHGAP11A is locally synthesized. Thus, RhoA activity is spatially and acutely activated via local translation in RGCs to promote neuron positioning and cortical cytoarchitecture. Altogether, our study demonstrates that mRNA localization and local translation mediate compartmentalization of neural progenitor functions to control brain development.HighlightsArhgap11a in radial glia non-cell autonomously promotes neuronal migration and laminationArhgap11amRNA localizes to radial glial endfeet via a 5’ UTR cis elementARHGAP11A expression in basal process and endfeet depends upon its localized mRNALocalized mRNA and RhoA-GAP activity in endfeet control radial glial morphology
Thalamic encoding of lexical status is lateralized during reading aloud
Authors: Wang Dengyu , Lipski Witold J. , Bush Alan , Chrabaszcz Anna , Dastolfo-Hromack Christina , Dickey Michael W. , Fiez Julie A. , Richardson R. Mark 
Published: July 2020

AbstractTo explore whether the thalamus participates in lexical status encoding, local field potentials were recorded in patients undergoing deep brain stimulation lead implantation while they read aloud single-syllable words and nonwords. Bilateral decreases in thalamic beta (12-30Hz) activity were preferentially locked to stimulus presentation, and these decreases were greater when nonwords were read. Increased broadband gamma (70-150Hz) activity also was locked preferentially to speech onset bilaterally, but greater nonword-related increases in this activity were observed only on the left, demonstrating lateralization of thalamic gamma selectivity for lexical status. In addition, this lexical status effect was strongest in more anterior thalamic locations, regions which are more likely to receive pallidal than cerebellar afferents. These results provide evidence from intracranial thalamic recordings for the lateralization and topography of subcortical lexical status processing.
Household margin insurance of agricultural sector in Indonesia using a farmer exchange rate index
Authors: Ahdika Atina , Rosadi Dedi , Effendie Adhitya Ronnie , Gunardi  
Published: July 2020

PurposeFarmer exchange rate (FER) is the ratio between a farmer's income and expenditure and is also an indicator of farmers’ welfare. There is little research regarding its use in risk modeling in crop insurance. This study seeks to propose a design for a household margin insurance scheme of the agricultural sector based on FER.Design/methodology/approachThis research employs various risk modeling concepts, i.e. value at risk, loss models and premium calculation, to construct the proposed model. The standard linear, static and time-varying copula models are used to identify the dependency between variables involved in calculating FER.FindingsFirst, FER can be considered as the primary variable for risk modeling in agricultural household margin insurance because it demonstrates farmers’ financial ability. Second, temporal dependence estimated using the time-varying copula can minimize errors, reduce the premium rate and result in a tighter guarantee's level of security.Originality/valueThis research extends the previous similar studies related to the use of index ratio in margin insurance loss modeling. Its authenticity is in the use of FER, which represents the farmers' trading capability. FER determines farmers’ losses by considering two aspects: the farmers’ income rate and their ability to fulfill their life and farming needs. Also, originality exists in the use of the time-varying copulas in identifying the dependence of the indices involved in calculating FER.
Career decisions of Indian female talent: implications for gender-sensitive talent management
Authors: Böhmer Nicole , Schinnenburg Heike 
Published: July 2020

PurposeTalent scarcity in emerging economies such as India poses challenges for companies, and limited labour market participation among well-educated women has been observed. The reasons that professionals decide not to pursue a further corporate career remain unclear. By investigating career decision-making, this article aims to highlight (1) the contextual factors that impact those decisions, (2) individuals' agency to handle them and (3) the implications for talent management (TM).Design/methodology/approachFollowing a qualitative research design, computer-aided analysis was conducted on interviews with 24 internationally experienced Indian business professionals. A novel application of neo-institutionalism in the Indian context was combined with the family-relatedness of work decisions (FRWD) model.FindingsCareer decisions indicate that rebellion against Indian societal and family expectations is essential to following a career path, especially for women. TM as part of the current institutional framework serves as a legitimising façade veiling traditional practices that hinder females' careers.Research limitations/implicationsInterviewees adopted a retrospective perspective when describing their career decisions; therefore, different views might have existed at the moment of decision-making.Practical implicationsDesign and implementation of gender-sensitive TM adjusted to fit the specific Indian context can contribute to retaining female talent in companies and the labour market.Originality/valueThe importance of gender-sensitive TM can be concluded from an empirical study of the context-based career decision-making of experienced business professionals from India. The synthesis of neo-institutionalism, the FRWD model and the research results provides assistance in mapping talent experiences and implications for overcoming the challenges of talent scarcity in India.
Inverse-thermocapillary evaporation in a thin liquid film of self-rewetting fluid
Authors: Lim Elaine , Kueh Tze Cheng , Hung Yew Mun 
Published: July 2020

Purpose
The present study aims to investigate the inverse-thermocapillary effect in an evaporating thin liquid film of self-rewetting fluid, which is a dilute aqueous solution (DAS) of long-chain alcohol.

Design/methodology/approach
A long-wave evolution model modified for self-rewetting fluids is used to study the inverse thermocapillary characteristics of an evaporating thin liquid film. The flow attributed to the inverse thermocapillary action is manifested through the streamline plots and the evaporative heat transfer characteristics are quantified and analyzed.

Findings
The thermocapillary flow induced by the negative surface tension gradient drives the liquid from a low-surface-tension (high temperature) region to a high-surface-tension (low temperature) region, retarding the liquid circulation and the evaporation strength. The positive surface tension gradients of self-rewetting fluids induce inverse-thermocapillary flow. The results of different working fluids, namely, water, heptanol and DAS of heptanol, are examined and compared. The thermocapillary characteristic of a working fluid is significantly affected by the sign of the surface tension gradient and the inverse effect is profound at a high excess temperature. The inverse thermocapillary effect significantly enhances evaporation rates.

Originality/value
The current investigation on the inverse thermocapillary effect in a self-rewetting evaporating thin film liquid has not been attempted previously. This study provides insights on the hydrodynamic and thermal characteristics of thermocapillary evaporation of self-rewetting liquid, which give rise to significant thermal enhancement of the microscale phase-change heat transfer devices.
Onboard activity choice of Chinese cruise tourists
Authors: Li Na 
Published: July 2020

Purpose
The purpose of this study is to explore the onboard activity choice of Chinese cruise tourists on three international cruise ships departing Shanghai, China.

Design/methodology/approach
A qualitative research method was adopted for this study. Data was collected using participant observation, casual conversation and semi-structured in-depth interviews from 76 Chinese cruise respondents. The data was analysed using thematic analysis.

Findings
Chinese cruise tourists were offered various onboard activities, most of which were Western. Booking these activities involved tourists searching information and assessing and choosing what appealed to them. They chose these activities according to the consumption values, and their decision was influenced by both context-dependent variables—the variety and style of the activities and their capacity to appeal, and the personal variable—age. Chinese tourists were satisfied with the array of onboard activity options and viewed them as an opportunity to experience Western culture. However, when they were unfamiliar with or did not understand some activities, they preferred Chinese activities.

Originality/value
This study formulates propositions to underlie a conceptual framework of how cruise tourists choose an onboard activity. The findings derived from the data will be valuable to cruise lines seeking to better manage tourists’ onboard experiences.
On IMF debt and capital control: evidence from Malaysia, Thailand, Indonesia, the Philippines and South Korea
Authors: Mohamad Azhar , Sifat Imtiaz Mohammad , Mohd Thas Thaker Hassanudin , Noor Anwar Muhammad 
Published: July 2020

Purpose
This study aims to investigate the effects of capital control and external debts after the 1997 financial crisis.

Design/methodology/approach
Using system estimation approach, the authors estimate a panel data-based econometric model for data on Malaysia, Thailand, Indonesia, the Philippines and South Korea from 1990 to 2017.

Findings
The authors find that on average, the crisis-hit South East Asian economies choosing external debt perform better in achieving greater economic growth and rebound better compared to economies imposing capital control.

Originality/value
This study attempts to answer whether a crisis-hit country should impose capital control or opt for external debt to recuperate from the crisis.
Public value budgeting: propositions for the future of budgeting
Authors: Douglas Scott , Overmans Tom 
Published: July 2020

PurposeThe principles of public value management (PVM) have greatly inspired public management practitioners and scholars, but the application of these ideas to the everyday practice and research of government has proven to be more difficult. This article formulates propositions for how the principles of PVM could affect one of the core processes of government: budgeting. These propositions can inspire practitioners and be tested by future researchers.Design/methodology/approachThe article identifies the core principles of PVM and applies these to the budgeting functions of the allocation, management and accountability of public money. This exploration leads to a first conceptualization of “public value budgeting” and generates 12 propositions about how budgeting will change and remain unaltered under the influence of PVM.FindingsThe central argument is that “public value budgeting” could promote more coordination and integration between public funds and community resources, more involvement of societal stakeholders in the budgetary process and more continuous tweaks and changes to the budget. At the same time, legislative vetoes, financial controls and debates about the best use of public money will remain an important feature of public budgeting.Originality/valueThe article forwards the first conceptualization of public value budgeting, connects the literatures on public value and public budgeting, and offers both a practical application of PVM to public budgeting as well as a concrete agenda for future research.
Do mergers and acquisitions affect information asymmetry in the banking sector?
Authors: Howe John S. , Morillon Thibaut G. 
Published: July 2020

PurposeThis paper aims to investigate the consequences of mergers and acquisitions (M&As) on information asymmetry in the banking sector. Specifically, the authors look at whether specific firm or deal characteristic influence information asymmetry levels between insiders and investors, as well as the impact of recent regulation such as the Dodd–Frank Act.Design/methodology/approachThe authors decompose the M&A process into three periods (pre-announcement, negotiation and post-completion period) and document changes in the information asymmetry levels between insiders and investors through the M&A process. The authors capture changes in information asymmetry using six different spread-based information asymmetry measures.FindingsThe authors find evidence that information asymmetry increases following M&A announcement and decreases following deal completion. These findings are more pronounced for acquisitions involving a private target, all-cash deals and for mergers, as opposed to acquisition of assets. We find that overall, successful mergers improve the quality of the information environment, while failed deals degrade it. Additionally, the enactment of Dodd–Frank reduced the magnitude of the changes in information asymmetry during the M&A process. The results are important to regulators, policy makers and investors.Originality/valueTo authors’ knowledge, this is the first study that looks at the effect of bank M&As on information asymmetry as well as the effect of regulations on information asymmetry.
The cost of players’ injuries to professional sports leagues and other sports organizations
Authors: Walia Bhavneet , Boudreaux Christopher John 
Published: July 2020

PurposeMost literature studies have focused on direct treatment costs of injuries. This literature is extended to include the foregone playing time of players as an additional injury cost.Design/methodology/approachThe authors have reviewed the literature on the cost of players’ injuries to professional sports leagues and other organizations.FindingsThe authors concluded that players’ injury costs are substantial and sufficiently variable to be a primary source of financial uncertainty for a team.Originality/valueThis study's value has added risk pooling and league-wide revenue sharing as tools to mitigate the risk of injury costs. Previous literature reviews focused predominately on direct treatment costs.
The interactive influence of human and social capital on capability development: the role of managerial diversity and ties in adaptive capability
Authors: Mitchell Rebecca , Boyle Brendan , Nicholas Stephen 
Published: July 2020

PurposeHow top management teams (TMTs) adapt and change to create and sustain competitive advantage is a fundamental challenge for human resource management studies. This paper examines the effects of TMT composition (human capital) and managerial ties (social capital) as factors that interactively explain managerial adaptive capability and organizational performance.Design/methodology/approachA unique survey dataset, derived through privileged access to organizational CEOs and CFOs of 101 Chinese organizations, was used to investigate a path between TMT functional diversity and organizational performance through adaptive managerial capability. Data were analysed using hierarchical multiple regression and Hayes (2012) PROCESS macro for SPSS.FindingsUnexpectedly, the results show that functional diversity has no direct positive effect on firm performance; however when functionally-diverse TMTs are embedded in external networks, there is a significant positive impact on managerial adaptive capability and, through this, competitive advantage.Research limitations/implicationsBy identifying TMT functional diversity as an important driver of adaptive managerial capability, contingent on managerial ties, this study addresses a significant research gap pertaining to how TMT characteristics potentially contribute to the development of a core organizational capability.Practical implicationsThe authors’ results highlight the importance of ensuring that recruitment into TMTs considers the complementarity of member functional background; however, benefit is only achieved when TMT members establish external ties with other organizations.Originality/valueThe authors’ findings provide evidence of the interactive effect of human and social capital on adaptive capability development and, through this, organizational performance.