bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aeromicrobium terrae sp. nov., isolated from a maize field
Authors: Lin Shih-Yao , Tsai Chia-Fang , Hameed Asif , Young Chiu-Chung 
Published: January 2021

A polyphasic taxonomic approach was used to characterize a Gram-stain-positive bacterium, designated strain CC-CFT486T, isolated from soil sampled in a maize field in Taiwan. Cells of strain CC-CFT486T were short rods, motile with polar flagella, catalase-positive and oxidase-positive. Optimal growth occurred at 30 °С, pH 8 and 1 % NaCl. Phylogenetic analyses based on 16S rRNA genes revealed a distinct taxonomic position attained by strain CC-CFT486T associated with

Aeromicrobium panacisoli

(97.0 % sequence identity),

Aeromicrobium lacus

(97.0 %),

Aeromicrobium erythreum

(96.8 %) and

Aeromicrobium alkaliterrae

(96.8 %), and lower sequence similarity values to other species. Average nucleotide identity (ANI) values were 70.6–77.8 % (n=11) compared within the type strains of the genus

Aeromicrobium

. Strain CC-CFT486T contained C16 : 0, C17 : 0, C17 : 1
ω8c and C18 : 1
ω9c as the predominant fatty acids. The polar lipid profile consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, two unidentified aminophospholipids and three unknown phospholipids. The cell wall peptidoglycan of strains CC-CFT486T contained ll-diaminopimelic acid (ll-DAP) and the major polyamine was spermidine. The DNA G+C content was 70.6 mol% and the predominant quinone was menaquinone 9 (MK-9). Based on its distinct phylogenetic, phenotypic and chemotaxonomic traits together with results of comparative 16S rRNA gene sequence and ANI analyses, strain CC-CFT486T is proposed to represent a novel

Aeromicrobium

species, for which the name Aeromicrobium terrae sp. nov. (type strain CC-CFT486T=BCRC 81217T=JCM 33499T).
Newcastle disease virus induced ferroptosis through p53-SLC7A11-GPX4 axis mediated nutrient deprivation in tumor cells
Authors: Kan Xianjin , Yin Yuncong , Song Cuiping , Tan Lei , Qiu Xusheng , Liao Ying , Liu Weiwei , Meng Songshu , Sun Yingjie , Ding Chan 
Published: January 2021

SummaryA number of new cell death processes have been discovered in recent years, including ferroptosis, which is characterized by the accumulation of lipid peroxidation products derived from iron metabolism. The evidence suggests that ferroptosis has a tumor-suppressor function. However, the mechanism by which ferroptosis mediates the response of tumor cells to oncolytic viruses remains poorly understood. Newcastle disease virus can selectively replicate in tumor cells. We show that NDV-induced ferroptosis acts through p53-SLC7A11-GPX4 pathway. The expression of tumor suppressor gene p53 increased after NDV infection, and the expressions of SLC7A11 and SLC3A2 were down-regulated, leading to the inhibition of glutathione synthesis and a decrease in glutathione peroxidase 4 expression. The chemical compound erastin, which induces ferroptosis, also down-regulated glutathione synthase expression and caused lipid peroxide accumulation and cell death. Meanwhile, the levels of intracellular reactive oxygen species and lipid peroxides increased in tumor cells. Ferritinophagy was induced by NDV promotion of ferroptosis through the release of ferrous iron and an enhanced Fenton reaction. Collectively, these observations demonstrated that NDV can kill tumor cells through ferroptosis. Our study provides novel insights into the mechanisms of NDV-induced ferroptosis and highlights the critical role of viruses in treating therapy-resistant cancers.
Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma
Authors: Chakiryan Nicholas H , Kimmel Gregory J , Kim Youngchul , Hajiran Ali , Aydin Ahmet M , Zemp Logan , Katende Esther , Nguyen Jonathan , Lopez-Blanco Neale , Chahoud Jad , Spiess Philippe E , Fournier Michelle , Dhillon Jasreman , Wang Liang , Moran-Segura Carlos , El-Kenawi Asmaa , Mulé James , Altrock Philipp M , Manley Brandon J 
Published: January 2021

ABSTRACTImmune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density metrics. Using multiplex immunohistochemistry and digital pathologic analysis we quantified cellular density and cellular clustering for myeloid cell markers in 129 regions of interest from 55 samples from 35 patients with metastatic ccRCC. CD68+ cells were found to be clustered with tumor cells and dispersed from stromal cells, while CD163+ and CD206+ cells were found to be clustered with stromal cells and dispersed from tumor cells. CD68+ density was not associated with OS, while high tumor/CD68+ cell clustering was associated with significantly worse OS. These novel findings would not have been identified if immune infiltrate was assessed using cellular density alone, highlighting the importance of including spatial analysis in studies of immune cell infiltration of tumors.SIGNIFICANCEIncreased clustering of CD68+ TAMs and tumor cells was associated with worse overall survival for patients with metastatic ccRCC. This effect would not have been identified if immune infiltrate was assessed using cell density alone, highlighting the importance of including spatial analysis in studies of immune cell infiltration of tumors.
The development and neuronal complexity of bipinnaria larvae of the sea starAsterias rubens
Authors: Carter Hugh F. , Thompson Jeffrey R. , Elphick Maurice R. , Oliveri Paola 
Published: January 2021

AbstractFree-swimming planktonic larvae are a key stage in the development of many marine phyla, and studies of these organisms have contributed to our understanding of major genetic and evolutionary processes. Although transitory, these larvae often attain a remarkable degree of tissue complexity, with well-defined musculature and nervous systems. Amongst the best studied are larvae belonging to the phylum Echinodermata, but with work largely focused on the pleuteus larvae of sea urchins (class Echinoidea). The greatest diversity of larval strategies amongst echinoderms is found in the class Asteroidea (sea-stars), organisms that are rapidly emerging as experimental systems for genetic and developmental studies. However, the bipinnaria larvae of sea stars have only been studied in detail in a small number of species and the full complexity of the nervous system is, in particular, poorly understood. Here we have analysed embryonic development and bipinnaria larval anatomy in the common North Atlantic sea-starAsterias rubens, employing use of a variety of staining methods in combination with confocal microscopy. Importantly, the complexity of the nervous system of bipinnaria larvae was revealed in greater detail than ever before, with identification of at least three centres of neuronal complexity: the anterior apical organ, oral region and ciliary bands. Furthermore, the anatomy of the musculature and sites of cell division in bipinnaria larvae were analysed. Comparisons of developmental progression and molecular anatomy across the Echinodermata provided a basis for hypotheses on the shared evolutionary and developmental processes that have shaped this group of animals. We conclude that bipinnaria larvae appear to be remarkably conserved across ~200 million years of evolutionary time and may represent a strong evolutionary and/or developmental constraint for species utilizing this larval strategy.
The “long term” as an instrument for deploying neoliberalism: the case of the myth of long-term compensation
Authors: Chakhovich Terhi 
Published: January 2021

PurposeThis study locates one surprisingly powerful ally of neoliberalism enabling its proliferation in certain contexts, the discursive notion of the “long term” (LT). Earlier literature has shown that neoliberalism is concerned with investors' decision-making that has been claimed to be based on LT forecasts. This research explains this focus on the “long term.”Design/methodology/approachShare-based compensation (SBC) is investigated in one case company. The data consist of interviews with executives, board members, analysts and owners and also of archival data on the executives' performance measurement and compensation.FindingsMuch research equates “share-based compensation” with “long-term compensation,” and the present study terms this relation “the myth of long-term compensation.” It is demonstrated that multiple features of share-based plans, characteristics of the management in question and contextual factors of the company and its governance tie in with the time orientation of such compensation. Multiple contradictions and irregularities in the literature on SBC are analyzed, undermining the claim that SBC is invariably LT oriented. Relying on Barthes' work, the study illustrates how LT SBC is a myth contributing to the ideology of neoliberalism.Research limitations/implicationsIt is proposed that the terms “share-based compensation” and “long term” be distinguished from each other for analytical and practical purposes. SBC, and thus neoliberalism, can sometimes be linked to the short term.Originality/value“Long term” is illustrated as a significant instrument for deploying ideologies.
The impact of board characteristics on corporate investment decisions: an empirical study
Authors: Agyei-Mensah Ben Kwame 
Published: January 2021

Purpose
The purpose of this study is to investigate the influence of board characteristics on firms’ investment decisions.

Design Methodology Approach
The study used data sourced from annual reports of firms listed on the Ghana Stock Exchange from 2014 to 2018. Descriptive analysis was performed to provide the background statistics of the variables examined. This was followed by a regression analysis which forms the main data analysis.

Findings
The multiple regression analysis results indicated that the proportion of independent directors and financial experts on the board are negatively related to firm investment. These findings imply that independent directors and financial experts on the board can help firms reduce overinvestment and improve investment efficiency.

Originality Value
The extant literature shows that the board of directors are an effective mechanism to reduce agency problems in firm decisions and operating performance. However, there has been little research on the role of the board of directors in corporate investment policy.
Increasing production efficiency through the reduction of transportation activities and time using 4D BIM simulations
Authors: Pérez Cristina Toca , Bastos Costa Dayana 
Published: January 2021

PurposeThis paper proposes to apply the lean philosophy principle of minimizing or eliminating non-value adding activities combined with 4D building information modeling (BIM) simulations to reduce transportation waste in construction production processes.Design/methodology/approachThis study adopts design science research (DSR) because of its prescriptive character to produce innovative constructions (artifacts) to solve real-world problems. The artifact proposed is a set of constructs for evaluating the utility of 4D BIM simulations for transportation waste reduction. The authors performed two learning cycles using empirical studies in projects A, B and C. The construction process of cast-in-place (CIP) reinforcement concrete (RC) was selected to demonstrate and evaluate 4D BIM's utility. The empirical studies focused on understanding the current transportation waste, collecting actual performance data during job site visits and demonstrating the usage of 4D BIM.FindingsIn the first cycle, 4D BIM successfully allowed users to understand the CIP-RC process's transportation activities, which were modeled. In the second cycle, 4D BIM enabled better decision-making processes concerning the definitions of strategies for placing reusable formworks for CIP concrete walls by planning transportation activities.Practical implicationsIn Cycle 2, three different scenarios were simulated to identify the most suitable formwork assembly planning, and the results were compared to the real situations identified during the job site visits. The scenario chosen demonstrated that the 4D BIM simulation yielded an 18.75% cycle time reduction. In addition, the simulation contributed to a decrease in transportation waste that was previously identified.Originality/valueThe original contribution of this paper is the use of 4D BIM simulation for managing non-value adding activities to reduce transportation waste. The utility of 4D BIM for the reduction of those conflicts considered three constructs: (1) the capacity to improve transportation activity efficiency, (2) the capacity to improve construction production efficiency and (3) the capacity to reduce transportation waste consequences.
Exploring the use of social media sites for health professionals' engagement and productivity in public sector hospitals
Authors: Naeem Muhammad , Ozuem Wilson 
Published: January 2021

PurposeCompetitive pressure and social influence for technology adoption have increased among developed, developing and emerging countries. The influence of social structure, organizational forces and political forces varies between public sector hospitals in countries where there are more social media restrictions. This study aims to explore how the use of social media can influence employee engagement and productivity in the workplaces of public sector hospitals.Design/methodology/approachThe study follows a social constructivist approach to understand employee attitudes, motivation culture, political forces and the local context. Data were collected from health professionals of five public sector hospitals using a non-directive and semi-structured interview method.FindingsThe results show that the use of social media sites has increased collaboration, coordination and cooperation among health professionals, especially in critical situations. They are more socialized, connected and engaged, thus helping them to exchange useful knowledge using instant messaging apps. Conversely, there are no organizational polices and specific laws and too little support from management and senior doctors to drive the use of social networking sites in public hospitals. The use of social media has enhanced health professionals' engagement and productivity as they are able to share their expertise, knowledge and information with their colleagues and subordinates.Research limitations/implicationsThe results can guide policy-makers, researchers, hospitals, doctors and the Ministry of Health about the positive use of social networking sites in the workplace. The positive use of social networking sites in the workplace can enhance information, knowledge and coordination which may help to enhance employee engagement and productivity.Originality/valueThe present study has provided a social media health organization workplace (SMHOW) model which explains how individual and organizational contexts can influence the actual use of social media in healthcare organizations.
Role of river stage in characterization of phreatic line
Authors: Kumar Vikram , Granthi Srivastava 
Published: January 2021

Purpose
The purpose of this study is to understand the basics of interactions of groundwater and surface water, which is needed for effective management of water resources.

Design/methodology/approach
The experimental setup was framed using curved flume and the straight flume, which simulates the model of river and groundwater storage, respectively. The model set up further consists, downstream, central and upstream sections where 14 observation wells, which are arranged at a measured distance from the canal side.

Findings
Exit gradient is higher at downstream when the average head differences between canal and river are 31.9 cm and 35.7 cm. Free seepage height is more in the downstream wells than upstream and central wells. At the downstream section, there is a greater chance of instability of the riverbank.

Research limitations/implications
Results will be used for better planning of hydraulic structural design.

Practical implications
Results will help in storing the large water and better irrigation planning for the water acute states and locations.

Originality/value
The originality is own developed physical model and its own first type to understand the basic of interaction and effects.
Gender in sustainability research: Inclusion, intersectionality, and patterns of knowledge production
Authors: Khalikova Venera R. , Jin Mushan , Chopra Shauhrat S. 
Published: January 2021

AbstractThis cross‐disciplinary study examines gender inclusion and intersectionality in the knowledge production of sustainability research. Building on studies of gender inclusion as essential for quality research, we develop a three‐step framework that analyzes the socio‐demographic profile of researchers (sustainability by whom?), key research trajectories (sustainability of what?), and beneficiaries of sustainability research (sustainability for whom?). Our methods include a survey and a bibliometric analysis. The survey was administered at the joint conference of the International Society for Industrial Ecology and the International Symposium on Sustainable Systems and Technology in 2017. The survey results show gendered differences in collaboration patterns. The survey results also indicated a good level of gender inclusion among the experts in this field, but the bibliometric analysis showed that gender issues remain marginal in the studies of industrial ecology. In contrast to industrial ecology, we found increasing attention to gender in other areas of sustainability research (climate change, corporate social responsibility, food production, resource management, energy policy, and environmental behavior and education), but even there, “gender” tends to be equated with “women” in traditional gender roles, ignoring the role of intersectionality—the intersection of gender with income, age, and other demographic characteristics. Therefore, this study makes recommendations to approach gender critically, by using theoretical lenses from gender studies scholarship (i.e., gender as a constructed, intersectional, dynamic category). We show how these lenses enable better assessments of the environmental impacts of industrial processes on people of diverse backgrounds in the context of changing patterns of work and consumption.
Dynamic evaluation of an in vivo postinflammatory hyperpigmentation model using reflectance confocal microscopy and spectrophotometry
Authors: Zhao Juemin , Liu Ziqi , Zhang Chengfeng , Wu Jiaqiang , Huang Nan , Du Yaping , Xiang Leihong 
Published: January 2021

AbstractBackgroundPostinflammatory hyperpigmentation (PIH) reflects a dynamic process from primary injury and cutaneous inflammation to subsequent melanogenesis and hyperpigmentation, of which pathogenesis remains unclear, hindering the development of targeted therapies.AimsTo observe the dynamic development of PIH; determine the starting point and peak point of the inflammatory phase and pigmentary phase; and clarify the timing of anti‐inflammatory and anti‐pigmentary treatment.MethodsThirty healthy volunteers with Fitzpatrick skin types III‐IV were enrolled and underwent suction blisters. The noninvasive evaluation of inflammation and hyperpigmentation on suction blister sites were performed via spectrophotometry (CM2600d and SIAscope) and RCM for the following 24 weeks.ResultsWe successfully observed suction blister‐induced PIH lasting over 24 weeks. The inflammatory phase started soon after the procedure and lasted for 8‐12 weeks, manifested by significantly elevated a* values and erythema index detected by spectrophotometry, as well as inflammatory infiltration and angiogenesis shown in RCM images. Meanwhile, melanogenesis was accelerated after week 3 and reached peak on week 8, manifested by significantly accumulated melanin granules and bright pigment rings in different depths under RCM, which was in parallel with elevated melanin index. The darkening skin tone in PIH actually presented a mixture of inflammatory erythema, angiogenesis, and hyperpigmentation. The inflammation and pigmentation phases of PIH were not sequential but partially overlap.ConclusionThe duration of suction blister‐induced PIH is more than 24 weeks. The inflammatory phase partially overlaps with the pigmentary phase, and those drugs with anti‐inflammatory and anti‐pigmentary dual effects are potential choices.
Indication of a reduction in the cover of thin‐leaved plants in Danish grasslands over an eight‐year period
Authors: Damgaard Christian 
Published: January 2021

AbstractQuestionAccording to leaf economics spectrum theory, the historic changes in several environmental factors, e.g. land use and nitrogen deposition, are expected to lead to selection of a change in the relative proportion of thin‐leaved and thick‐leaved plant species. However, it is generally unknown how fast plant communities respond to environmental changes.LocationDenmark.MethodsTime‐series analysis of Danish grassland pin‐point plant cover data from an eight‐year period.ResultsAcross four grassland habitat types, the cover of thin‐leaved plants was found to decrease significantly, but generally only limited trait selection was observed on leaf traits (specific leaf area [SLA] and leaf dry matter content [LDMC]). The mostly negative result may partly be due to the relatively conservative analysis, where the continuous plant trait variables are used for grouping plant species into functional types, which are then treated as dependent variables. This method was chosen in order to account for the sampling process of the vegetation data and is in contrast to most other analyses of trait selection, where it is the community‐weighted mean of the traits that is used as the dependent variable.ConclusionsOnly limited leaf trait selection was observed in semi‐natural grasslands that was not subjected to successional processes.