bluuebunny/crossref_metadata_2025_split huggingface dataset:
SGTA associates with nascent membrane protein precursors
Authors: Leznicki Pawel , High Stephen 
Published: April 2020

AbstractThe endoplasmic reticulum (ER) is a major site for membrane protein synthesis in eukaryotes. The majority of integral membrane proteins are delivered to the ER membrane via the co‐translational, signal recognition particle (SRP)‐dependent route. However, tail‐anchored proteins employ an alternative, post‐translational route(s) that relies on distinct factors such as a cytosolic protein quality control component, SGTA. We now show that SGTA is selectively recruited to ribosomes synthesising a diverse range of membrane proteins, suggesting that its biosynthetic client base also includes precursors on the co‐translational ER delivery pathway. Strikingly, SGTA is recruited to nascent membrane proteins before their transmembrane domain emerges from the ribosome. Hence, SGTA is ideally placed to capture these aggregation prone regions shortly after their synthesis. For nascent membrane proteins on the co‐translational pathway, SGTA complements the role of SRP by reducing the co‐translational ubiquitination of clients with multiple hydrophobic signal sequences. On this basis, we propose that SGTA acts to mask specific transmembrane domains located in complex membrane proteins until they can engage the ER translocon and become membrane inserted.
The Chloraea from Lima, a little-known species but described several times
Authors: Trujillo Delsy , Paredes-Burneo Diego 
Published: April 2020

During the botanical expedition carried out in Peru by Ruiz and Pavón, later by Raimondi’s explorations and finally by Weberbauer’s, specimens of a Chloraea species were collected in localities around Lima and used to describe Chloraea pavonii, C. undulata and C. peruviana. In this study we reviewed original materials, protologues, drawings, additional herbarium specimens and living material to clarify the taxonomic status of C. pavonii. A description, illustration, photographs, and distribution of the species are provided. We also point out the morphological features that distinguish C. pavonii from C. densipapillosa and C. septentrionalis. Lectotypes for C. undulata and C. peruviana are here designated.
Key Words: Chloraea, Lima, Peru, lectotypification, lomas ecosystem
Implementation of Good Governance Business Sharia (GGBS) and Its Implications for Sharia Conformity and Profitability (SCnP) Financial Performance in Sharia Commercial Banks in Indonesia
Authors: Apriani Nindi , Kusnendi Kusnendi , Firmansyah Firmansyah 
Published: April 2020

Abstract. Financial performance is an analysis carried out to see the extent to which a company carries out the rules of implementing finances properly and correctly. The measurement of the financial performance of Islamic banks mostly still uses conventional measurement indicators namely profitability. This is considered less relevant, because the measurement of the performance of Islamic banks should be measured based on the suitability of sharia. Sharia Conformity and Profitability is a tool that measures the integrity of a bank, but still does not ignore the conventional side because the purpose of Islamic banks is to seek profit. This study aims to analyze the influence of Good Governance Business Sharia on Sharia Conformity and Profitability of Islamic Commercial Banks in Indonesia. The population in this study used all Islamic Commercial Banks (BUS) in Indonesia. The sample used was eleven Sharia Commercial Banks in Indonesia in 2012-2016. The method in this study uses explanatory research methods. The data analysis technique used is panel data regression. The results showed that the level of implementation of Good Governance Business Sharia was good enough and tended to increase. The Sharia Conformity and Profitability level of Islamic Commercial Banks in Indonesia has a high level of performance which means that the average performance is above on average. The implementation of Good Governance Business Sharia (GGBS) has a positive effect on Sharia Conformity but has a negative effect on Profitability. The results have important implications for Islamic Commercial Banks and regulator regarding Good Governance Business Sharia that should be modified as it aligns with sharia conformity but does not have impact on profitability. Keywords. Financial performance, Sharia Conformity and Profitability, Good Governance Business Sharia.
The Effect of Spiritual Motivation and Compensation on The Employee Performance of The Bank of Center Sharia Jabar Banten
Authors: Rahmawati Laili 
Published: April 2020

Abstract. Nowadays, the sharia banking industries in Indonesia have increased dramatically because there are many the companies of conventional banking that have redeveloped to be a the sharia banking. According to many, the industries of sharia banking require the systems that can spur them to be a large banking company not only in Indonesia but also in the world. Meanwhile, the sources that they have both of human and natural resources respectively need the increasing to compete in this era. Moreover, to enhance the capacity of employees are indispensable work to create the greate employee and this is quite essential for the sharia banking companies. The aim of this study is to provide a describing regarding the impact of spiritual motivation and compensation on the employee performance. The methodology that be used in this research is a survey method with explanatory likewise the spiritual motivation and the compensation are independent variable meanwhile employee performance is dependent variable. In addition, the location of the survey is in the Bank of Center Sharia Jabar Banten. The result of the study has delivered that both of the spiritual motivation and the compensation have the significant positive impact to incline the employee performance of the Bank of Center Sharia Jabar Banten. Keywords. Sharia Banking, Spiritual Motivation, Compensation and Employee Performance.
Implementation of Aqad Musyarakah Mutanaqisah (MMQ) Take Over Financing on KPR Products in Sharia Banks
Authors: Ashsiddiqqy Muhammad Rafi , Monoarfa Hilda , Cakhyaneu Aneu 
Published: April 2020

Abstract. House Ownership Financing (PKR) there are various types of contracts used, one of which is Musyarakah Mutanaqisah (MMQ). However, financing through the Mushanaqishah Mutanaqishah pattern (MMQ) has some common problem in the banking world faced. This study aims to see how the implementation of Musharaka Mutanaqishah (MMQ) contract. Take Over financing on KPR products is in accordance with Fatwa DSN MUI Number: 73 / DSN-MUI / XI / 2008 concerning Musyarakah Mutanaqisah (MMQ) .This study use descriptive quantitative method. The population in this study were mortgage customers totaling 31 people with census techniques. The instrument in this study used a questionnaire. The results showed the implementation of Musyarakah Mutanaqisah (MMQ) agreement. Take Over financing for KPR products is in a good category, although there are several indicators in the sufficient category. Keywords. Musharakah Mutanaqisah (MMQ), Take Over Financing, Shariah Home Financing.
Clinical and genetic characteristic of patients with Pitt–Hopkins syndrome
Authors: Kondakova Olga B. , Grebenkin Dmitry I. , Lyalina Anastasiya A. , Krustaleva Evgeniya V. , Kanivets Ilya V. , Batysheva Tatiana T. 
Published: April 2020

Background. PittHopkins syndrome (PHS) is the rare inherited disease, caused by a microdeletion on chromosome 18q21 or heterozygous mutation TCF4 gene and characterized by severe mental retardation, abnormal breathing patterns: hyperventilation, apnea, and unusual facial features.
Material and method. We examined 9 children, included 4 boys and 5 girls at the age of 1 year 8 months to 12 years with PHS. All children have clinical symptoms characteristic of this syndrome. The diagnosis was confirmed by Array CGH (deletion of genomic material in chromosomal region 18q21) and new generation sequencing.
Results. Microdeletions chromosome 18 (18q21) were identified in 5 patients. The size of the microdeletions varied from 307 Kb to 11.62 Mb. A point mutation was detected in 4 children: two patients had a mutation in the splicing site, 1 missense and 1 nonsense-mutation. The clinical picture was analyzed in all children: psychomotor retardation, severe intellectual disability, poor speech, autistic behavior, hypotonia, and specific phenotype.
Conclusion. Comparative analysis of the clinical picture in patients with PHS, caused by a microdeletion on chromosome 18q21 and point mutation in the TCF4 gene showed that no significant clinical differences were found. The main clinical criteria for suspecting PHS are gross developmental delay, severe delayed psychomotor development, behavioral disorders, and episodes of hyperventilation with the subsequent apnea.
Protective Effects of Ferulic Acid in Alcohol Withdrawal Induced Anxiety and Depression in Mice
Authors: Kotwal Suraj , Upaganlawar Aman B. , Mahajan Manoj , Upasani Chandrashekhar 
Published: April 2020

Background: Anxiety and depression are the most important troubling symptoms of continuous alcoholism. Objective: The present study was designed to examine the protective effects of ferulic acid in alcohol withdrawal-induced anxiety and depression in experimental mice.
Methods: Male albino mice were divided into different groups. They were received 10% ethanol (2 g/kg; p.o.) twice on the first day and once on successive days for total six days, after 24 hrs. Withdrawal symptoms were observed using the different model for anxiety and depression such as elevated plus maze, open field test, hole board test, marble burying test and tail suspension test. Ferulic acid was tested as 10 and 20 mg/ kg, orally.
Results: Treatment with ferulic acid (10 and 20 mg/kg, p.o) showed significant reduction of alcohol withdrawal syndromes in different models. Taken together our result showed a protective effect in alcohol withdrawal anxiety and depression as tested in well-established animal models.
Conclusion: The present study showed that ferulic acid dose-dependently prevents alcohol withdrawal-induced anxiety and depression in mice.
Assessment of Hypertension Self-Care Behaviors and Self-Efficacy Among Men in Saudi Arabia
Authors: Bahari Ghareeb , Scafide Katherine , Weinstein Ali A. , Krall Jenna , Han Hae-Ra 
Published: April 2020

Background and PurposeHypertension is rapidly increasing in the Kingdom of Saudi Arabia (KSA), particularly among men. Assessment of hypertension self-care behaviors is a critical step to promoting blood pressure control. This study aimed to evaluate the Hypertension Self-Care Profile (HBP-SCP) among Saudi men in KSA.MethodsThe HBP-SCP self-efficacy and behavior scales were translated into Arabic and tested on a convenience sample of 160 Saudi men with hypertension. Cronbach's alpha and factor analysis were conducted using SPSS.ResultsInternal consistency of the Arabic HBP self-care and self-efficacy scales was 0.84 and 0.90, respectively. Factor loading ranged from 0.25 to 0.70 for HBP self-care behaviors and from 0.28 to 0.77 for HBP self-efficacy.ConclusionsThe Arabic HBP-SCP is acceptable in its reliability and validity for measuring HBP self-care behaviors and self-efficacy among Saudi men with hypertension.
La constancia del movimiento. Olga Tokarczuc. Premio Nobel de Literatura 2018
Authors: Vivar Mendoza Aldo 
Published: April 2020

La literatura centroeuropea está llena de sorpresas. Olga Tokarczuk es una de ellas. Casi desconocida para los lectores hispanoamericanos, posee una obra cautivante que combina narrativa y ensayo, realidad y magia, movimiento y constancia.
Sellado de suelos, fragmentación y conectividad ecológica en la conurbación de Madrid (España)
Authors: García Alvarado José María , Pérez González María Eugenia , García Rodríguez María Pilar 
Published: April 2020

La rápida expansión de la ocupación urbana en las últimas décadas está provocando un crecimiento de la impermeabilización del suelo no justificable por el valor del crecimiento de la población, con injustificables agresiones medioambientales. Por ello, se debería optar por una mayor integración de los espacios urbanos con su entorno naturalizado, generando menor huella ecológica, y el mayor valor de resiliencia frente a los fenómenos naturales catastróficos, que se incrementarán según se presentan en los diferentes escenarios de cambio climático. El objetivo del estudio es valorar la intensidad del sellado de suelo como medida de la fragmentación ecológica, y con la finalidad de aportar algunas medidas que pudieran mejorar la conectividad ecológica a diferentes escalas en Madrid (España). Se utiliza una metodología fácilmente actualizable y gratuita, mediante el libre acceso a las imágenes satelitales Sentinel y a diversas fuentes cartográficas. En 2018, la conurbación de Madrid ya consumió de media el 18,5 % del suelo, con grandes variaciones espaciales (13,33 % al N y 41,41 % al S), por lo que las propuestas de mitigación deberán ser también dispares.
Effects of blended versus offline case-centered learning on academic performance and critical thinking ability among undergraduate nursing students：a cluster randomized controlled trial
Authors: Yu Zhenzhen , Shen Ling , Zhuang Jiayuan , Chen Yimin , Chen Meijing , Lin Yazhu , Hu Rong 
Published: April 2020

Abstract
Background: Educational reform, especially methods of teaching, has been a focus among nursing educators. This study explored the impact of blended versus offline case-centered learning on academic performance of Medical Nursing and critical thinking ability among undergraduate nursing students.Methods: A cluster randomized controlled study design was used, with assessments immediately before and one school year after the intervention. All the second-year undergraduate nursing students in two class were enrolled in this study by cluster sampling. The two classes of Medical Nursing were randomly allocated to either the experimental class, which undertook blended case-centered learning, or the control class, which undertook offline case-centered learning. The primary outcomes were academic performance consisting of final exam and process assessment, as well as the critical thinking ability assessed with the Critical Thinking Disposition Inventory-Chinese Version (CTDI-CV). The Mann-Whitney U test and the unpaired t test was subsequently used. ANCOVA analyses were also performed to examine the two teaching methods’ effect on academic performance and critical thinking.Results: Students in the experimental class showed a significantly higher improvement in academic performance of Medical Nursing than the control class. In addition, compared with the control class, the pre-post difference in competency in critical thinking self-confidence in the experimental class was significantly greater (p=0.037). In the experimental class, there was significant improvement compared with baseline in dimension of critical thinking self-confidence (p=0.022). In the control class, there was significant improvement compared with baseline in the total score (p=0.029) and two of the seven dimensions: truth-seeking (p=0.016) and systematicity (p=0.005).Conclusions: Use of the blended case-centered learning showed the promising results in promoting students’ academic performance. Both the blended and offline case-centered learning in this study were a suitable educational approach to improve the critical thinking ability of undergraduate nursing students. In the future, blended and offline case-centered learning could be implemented in other nursing subjects. Moreover, further efforts to improve teaching are warranted.
Prevalence of Pseudoexfoliation among Adults and its Related Ophthalmic Variables in the Community of Kebena Woreda, Gurage Zone, Ethiopia
Authors: SHERIEF SADIK Taju , Kibru Ephrem , Shibeshe Menen Ayalew 
Published: April 2020

Abstract
Background: Clinical studies in the hospital settings using patients having ocular morbidities have shown a high prevalence of pseudoexfoliation (PXF) in Ethiopia. With this information in mind community based study was conducted to determine prevalence and socio demographic factors of pseudoexfoliation syndrome among adults in Southern Ethiopia.Methods: A community based Crosse sectional study was conducted among subjects aged 40 years or older. Subjects underwent standardized examination, including portable slit lamp biomicroscopy before and after pupillary dilatation, and IOP measurement using Tono-Pen. Pseudoexfoliation was diagnosed on slit lamp exam by the presence of white dandruff-like material on the pupillary margin and/or on the anterior lens capsule of one or both eyes. Results: Among 760 participants, the prevalence of Pseudoexfoliation(PXF) was 12.0% (95% confidence interval, 9.7%-14.3%). The mean age was 63.9 years (SD 9.96, age range 40-90 years). The prevalence increased with increasing age, with 26.9% of those 60 or older affected. Slightly higher proportion of males (12.4%) were found to have Pseudoexfoliation in either of the eyes than females (11.6%) which was not statistically significant (p=0.738). Mean IOP in subjects with PXF was found to be 20.65 + 5.15 mmHg, while it was 15.0 + 2.3mmHg for those without PXF. The difference between the two populations was found to be statistically significant (P<0.05).Conclusions: The prevalence of PXF in eyes of people in Southern Ethiopia appears greater than that reported in other places of Africa and Asia. PXF occurs at a relatively younger age in our population. Increasing age is associated with the presence of PXF, and PXF in turn is associated with high IOP.
WITHDRAWN: Why Did They Fail? A Case Study on Undergraduate First Year Medical Students
Authors: Holder Nurul Atira Khairul Anhar , Nazri Nik Nadia Nik , Foong Chan Choong , Pallath Vinod , Sim Joong Hiong , Hong Wei-Han , Vadivelu Jamuna 
Published: April 2020

Abstract
Background: Academic struggle is a concern for students, medical schools and the society. As academic struggle is not idiopathic and instantaneous, qualitative research could provide an in-depth understanding on why it occurs. This qualitative research aimed to explore the reasons for why Year 1 medical students failed in their studies.Methods: This study adopted a single, embedded case design. Six medical students repeating their Year 1 studies performed a written reflection describing their experiences and behaviours during Year 1. Semi-structured interviews were then conducted with each student and data was analysed by two researchers. Independent analysis was compared, and discrepancies were resolved through discussions between the researchers. Results: Each student narrative demonstrated difference in behaviours and experiences. Students engaged less in studies or had ineffective learning methods. Narratives indicated various reasons such as being overconfident or unmotivated to study for these behaviours. However, interpreting based on Theories of Action, the students’ failures could be explained by three types of invalid governing variables found in the data. Students may have performed their actions based on either inadequate knowledge, possessing misbeliefs or have no rationales at all. Invalid governing variables may have led to ineffective actions, and subsequently resulted in unintended consequences. Hence, all students failed the mid-year and/or end-year assessments. Conclusion: Struggling students lacked the valid governing variables in rationalising their actions. One suggestion based on the Theories of Action is the recommendation that students perform double loop learning to deeply assess and alter their governing variables.
Impacts of stigma and discrimination in the workplace on people living with psychosis
Authors: Hampson Margaret E , Watt Bruce D , Hicks Richard Edward 
Published: April 2020

Abstract
Background. Employment holds many benefits for people living with psychosis. However, significant barriers to employment for this cohort appear to exist, notably stigma and discrimination against people living with serious mental health conditions. We asked: Would a qualitative sample including multiple stakeholder groups reveal similar results and if so, what would be the main impacts of such stigma and discrimination? Method. This analysis used data from a qualitative study that had applied focus groups and interviews to investigate the employment barriers and support needs of people living with psychosis, including views of the multiple stakeholders (such as those living with mental health conditions, health professionals, and employers). Results: The analyses confirmed the most frequently referenced barriers to employment were stigma and discrimination. The main impacts of workplace stigma and discrimination on people living with psychosis involved five areas: work avoidance, reluctance to disclose mental health conditions to employers, work-related stress, and reduced longevity of employment. Conclusions. As in earlier studies, the main barriers to employment for those living with psychosis were stigma and discrimination, and significant impacts from such stigma and discrimination were found in this study. The findings indicate a need to provide support mechanisms and to change the culture of workplaces to improve employment opportunities and outcomes for people living with psychosis.
Influence of Time Under Mechanical Ventilation on Bronchopulmonary Dysplasia Severity in Extremely Preterm Infants: A Pilot Study.
Authors: Escobar Victoria , Soares Darllyana , Kreling Jane , Ferrari Ligia , Felcar Josiane M. , Camillo Carlos A. M. , Probst Vanessa Suziane 
Published: April 2020

Abstract
Background: The relation between mechanical ventilation (MV) and bronchopulmonary dysplasia (BPD) - a common disease in extremely premature newborn (PTNB) - is well stabilished, but is unknown, however, how much time under MV influences the severity of the disease. Aim: To define the duration under MV with greater chance to develop moderate to severe BPD in extremely PTNB and to compare clinical outcomes before and during hospitalization among patients with mild and moderate to severe BPD. Methods: 53 PTNB were separated into mild and moderate to severe BPD groups and their data were analyzed. Time under MV with a greater chance of developing moderate to severe BPD was estimated by the ROC curve. Perinatal and hospitalization outcomes were compared between groups. A logistic regression was performed to verify the influence of variables associated to moderate to severe BPD development, such as pulmonary hypertension (PH), gender, gestational age (GA) and weight at birth, as well the time under MV found with ROC curve. The result of ROC curve was validated using an independent sample (n=16) by Chi-square test. Results: Time under MV related to a greater chance of developing moderate to severe BPD was 36 days. Moderate to severe BPD group had more males (14 vs 5, p=0,047), longer time under MV (43 vs 19 days, p<0,001), more individuals with PH (12 vs 3, p=0,016), worse retinopathy of prematurity (grade 3, 2 vs 11, p=0,003), longer hospital length of stay (109 vs 81,5 days, p<0,001), greater PMA (41 vs 38 weeks, p<0,001) and weight (2620 vs 2031 grams, p<0,001) at discharge and the mild BPD group had more CPAP use prior to MV (12 vs 7, p=0,043). Among all variables included in logistic regression, only PH and MV<36 days were significant in the model, explaining 72% of variation in moderate to severe BPD development. In the validation sample, prevalence of preterm infants who needed MV for more than 36 days in the moderate to severe BPD group was 100% (n=6) and 0% in mild BPD group (p=0,0001). Conclusion: Time under MV related to moderate to severe BPD development is 36 days, and worst outcomes are related to disease severity. PH and time under MV for more than 36 days are related to development of moderate to severe BPD.