bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of 10 Pediatric Nephrotic Syndrome Cases With Complications of Cerebral Sinovenous Thrombosis
Authors: Rong Liping , Chen Lizhi , Dong Zhi , Zhuang Hongjie , Lin Zhilang , Mo Ying , Jiang Xiaoyun 
Published: December 2020

Background: To analyze the clinical characteristics of nephrotic syndrome (NS) with complications of cerebral sinovenous thrombosis (CSVT) in children.Method: Clinical, radiographic, laboratory, and treatment data obtained from 10 confirmed cases of NS with complications of CSVT were analyzed. All patients were followed up for at least 18 months. CSVT was diagnosed by cerebral computed tomography (CT) and/or magnetic resonance imaging (MRI) with or without magnetic resonance venography (MRV) of the cerebral vessels.Results: Among 10 cases reported, 4 were steroid-sensitive NS with frequent relapse, 5 were steroid-resistant (three of them had renal biopsies showing two minimal change disease and one IgA nephropathy), and 1 was steroid-sensitive with one relapse. Common clinical manifestations were headache or ophthalmodynia complicated by vomiting, dizziness, convulsion, and coma. Neuropathologic signs were positive in some cases. Papilledema appeared in only one case with winding of vein. Cerebrospinal fluid was examined in three cases with elevated pressure but normal cytological and biochemical results. D dimer and fibrinogen levels were elevated while prothrombin time and activated partial thromboplastin time were shortened. Five out of seven cases who had performed cranial CT were suspicious for cerebral thrombosis. Nine cases had cranial MRI with abnormal signs in seven cases. All of the cases received MRV, confirming the diagnosis of CVST.Conclusion: Clinical manifestations of NS with CSVT are not specific but varied. Therefore, CSVT should be considered once nervous manifestations present. MRV is a better method in the diagnosis of CSVT.
Pharmacokinetics and Pharmacodynamics of the Combination of Rhein and Curcumin in the Treatment of Chronic Kidney Disease in Rats
Authors: He Xiaoying , Li Guowei , Chen Yuanyuan , Xiao Qiming , Yu Xinwei , Yu Xixi , Lu Xiaoyang , Xiang Zheng 
Published: December 2020

Objectives: The interaction between the components of traditional Chinese medicine (TCM) is an important basis for their synergy. Rhein and curcumin exert various pharmacological activities, including anti-tumour, anti-inflammatory, antioxidant, anti-fibrosis and renoprotective effects. However, no investigation has reported the synergistic anti-fibrosis effect yet. This study aims at determine the pharmacokinetics and pharmacodynamics of the combination of rhein and curcumin in the treatment for chronic kidney disease in rats.Design: Fifty two male Sprague-Dawley (SD) rats were randomly divided into rhein group, curcumin group and their combination group for pharmacodynamics studies. HE and Masson staining was conducted to observe the changes of renal morphology. Kits were used to detect the level of urea nitrogen (BUN) and creatinine (Scr). For pharmacokinetic study, 36 SD rats were randomly divided into rhein group, curcumin group and a combination group, the content of rhein and curcumin in plasma and renal tissue was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). In additon, molecular docking method and cell experiments was used to disclose the interaction mechanism between curcumin and rhein.Results: The pharmacodynamic results showed that the degree of renal fibrosis was improved obviously by co-administration rhein and curcumin. Meanwhile, compared to single administration, the Cmax and AUC of rhein and curcumin in plasma and renal tissue were enhanced significantly after co-administration. Moreover, the result of molecular docking and cell experiments showed that both two compounds could interact with P-gp, CYP2C9 and CYP2C19.Conclusion: Together, these findings demonstrated that rhein and curcumin had a synergistic effect in ameliorateing chonic kidney disease, providing an important explanation on the synergistic mechanism of curcumin and rhein from a pharmacokinetic viewpoint.
Oxygen in Red Blood Cell Concentrates: Influence of Donors’ Characteristics and Blood Processing
Authors: Bardyn Manon , Martin Agathe , Dögnitz Nora , Abonnenc Mélanie , Dunham Andrew , Yoshida Tatsuro , Prudent Michel 
Published: December 2020

Objective: Unexpectedly wide distribution (&lt;10 to &gt;90%) of hemoglobin oxygen saturation (sO2) within red cell concentrates (RCCs) has recently been observed. Causes of such variability are not yet completely explained whereas the roles of oxygen and oxidative lesions during the storage of RCCs are known. The objectives of the present study are to characterize sO2 distribution in RCCs produced in a Swiss blood center and to investigate the influence of processing and donors’ characteristics.Methods: The level of sO2 was measured in 1701 leukocyte-depleted RCCs derived from whole blood donations in both top–bottom (TB; component filtered, SAGM) and top–top (TT; whole blood filtration, PAGGSM) RCCs. The sO2 value was measured non-invasively through the PVC bag prior to storage by resonance Raman spectroscopy. Gender, age, blood type, hemoglobin level, and living altitude of donors, as well as process method and time-to-process were recorded.Results: Overall, the sO2 exhibited a wide non-Gaussian distribution with a mean of 51.2 ± 18.5%. Use of top-top kits resulted in a 16% higher sO2 (P &lt; 0.0001) than with top-bottom ones. Waiting time before processing only had a modest impact, but the blood processing itself reduced the sO2 by almost 12% (P &lt; 0.0001). sO2 was also significantly affected by some donors’ characteristics. RCCs from men exhibited 25% higher sO2 (P &lt; 0.0001) than those donated by women. Multivariate analysis revealed that the apparent correlation observed with hemoglobin level and age was actually due to multicollinearity with the sex variable. Finally, we noticed no significant differences across blood type but found that altitude of residence was associated with the sO2 (i.e., higher in higher living place).Conclusion: These data confirm wide sO2 distribution in RCCs reported recently. The sO2 was impacted by the processing and also by donors’ characteristics such as the gender and the living altitude, but not by the hemoglobin level, blood group and donor age. This study provides new hints on the factors influencing red blood cells storage lesions, since they are known to be related to O2 content within the bags, giving clues to better process and to better store RCCs and therefore potentially improve the efficacy of transfusion.
Less Is More—Cyclists-Triathlete’s 30 min Cycling Time-Trial Performance Is Impaired With Multiple Feedback Compared to a Single Feedback
Authors: Bayne Freya , Racinais Sebastien , Mileva Katya , Hunter Steve , Gaoua Nadia 
Published: December 2020

Purpose: The purpose of this article was to (i) compare different modes of feedback (multiple vs. single) on 30 min cycling time-trial performance in non-cyclist’s and cyclists-triathletes, and (ii) investigate cyclists-triathlete’s information acquisition.Methods: 20 participants (10 non-cyclists, 10 cyclists-triathletes) performed two 30 min self-paced cycling time-trials (TT, ∼5–7 days apart) with either a single feedback (elapsed time) or multiple feedback (power output, elapsed distance, elapsed time, cadence, speed, and heart rate). Cyclists-triathlete’s information acquisition was also monitored during the multiple feedback trial via an eye tracker. Perceptual measurements of task motivation, ratings of perceived exertion (RPE) and affect were collected every 5 min. Performance variables (power output, cadence, distance, speed) and heart rate were recorded continuously.Results: Cyclists-triathletes average power output was greater compared to non-cyclists with both multiple feedback (227.99 ± 42.02 W; 137.27 ± 27.63 W; P &lt; 0.05) and single feedback (287.9 ± 60.07 W; 131.13 ± 25.53 W). Non-cyclist’s performance did not differ between multiple and single feedback (p &gt; 0.05). Whereas, cyclists-triathletes 30 min cycling time-trial performance was impaired with multiple feedback (227.99 ± 42.02 W) compared to single feedback (287.9 ± 60.07 W; p &lt; 0.05), despite adopting and reporting a similar pacing strategy and perceptual responses (p &gt; 0.05). Cyclists-triathlete’s primary and secondary objects of regard were power (64.95 s) and elapsed time (64.46 s). However, total glance time during multiple feedback decreased from the first 5 min (75.67 s) to the last 5 min (22.34 s).Conclusion: Cyclists-triathletes indoor 30 min cycling TT performance was impaired with multiple feedback compared to single feedback. Whereas non-cyclist’s performance did not differ between multiple and single feedback. Cyclists-triathletes glanced at power and time which corresponds with the wireless sensor networks they use during training. However, total glance time during multiple feedback decreased over time, and therefore, overloading athletes with feedback may decrease performance in cyclists-triathletes.
The Efficacy of Fecal Microbiota Transplantation for Children With Tourette Syndrome: A Preliminary Study
Authors: Zhao Hui-Jun , Luo Xi , Shi Yi-Chao , Li Jian-Feng , Pan Fei , Ren Rong-Rong , Peng Li-Hua , Shi Xiu-Yu , Yang Guang , Wang Jing , Hu Lin-Yan , Zou Li-Ping , Yang Yun-Sheng 
Published: December 2020

Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a single administration of FMT via endoscopy. Tic symptoms were assessed by Yale Global Tic Severity Scale-Total Tic Score (YGTSS-TTS) and adverse effects were recorded at week 8 following FMT. Lipopolysaccharide (LPS) levels and 14 cytokines levels were measured. The microbiota profile in feces were analyzed by shotgun metagenomics. Four patients (4/5) responded positively to FMT (YGTSS-TTS reduction rate &gt;25%) at week 8 with high safety. The levels of LPS and cytokines varied after FMT. FMT shifted the composition of the gut microbiota in patients close to that of the donor and continuously changed the abundance of Bacteroides coprocola, Dialister succinatiphilus and Bacteroides vulgatus. The restoration of B.coprocola was correlated with the improvement in tic symptoms (Spearman R = −0.900, P = 0.037). In conclusion, FMT was indicated a potential effective and safe alternative for patients with TS. However, larger clinical trials are needed to confirm the influence of microbiota in TS.Trial Registration:chictr.org.cn Identifier: ChiCTR-IIR-17011871, URL: http://www.chictr.org.cn/showproj.aspx?proj=19941.
Are Changes in Personality Traits and Alcohol Use Associated? A Cohort Study Among Young Swiss Men
Authors: Gmel Gerhard , Marmet Simon , Studer Joseph , Wicki Matthias 
Published: December 2020

Objective: It is well known that certain personality traits are associated with alcohol use. Because less is known about it, we wished to investigate whether changes in alcohol use were longitudinally associated with changes in personality and in which direction the influence or causation might flow.Methods: Data came from the self-reported questionnaire answers of 5,125 young men at two time points during the Cohort study on Substance Use Risk Factors (C-SURF). Their average ages were 20.0 and 25.4 years old at the first and second wave assessments, respectively. Four personality traits were measured: (a) aggression–hostility; (b) sociability; (c) neuroticism–anxiety; and (d) sensation seeking. Alcohol use was measured by volume (drinks per week) and binge drinking (about 60+ grams per occasion). Cross-lagged panel models and two-wave latent change score models were used.Results: Aggression–hostility, sensation seeking, and sociability were significantly and positively cross-sectionally associated with both alcohol use variables. Drinking volume and these three personality traits bidirectionally predicted each other. Binge drinking was bidirectionally associated with sensation-seeking only, whereas aggression–hostility and sociability only predicted binge drinking, but not vice versa. Changes in alcohol use were significantly positively associated with changes in aggression–hostility, sensation seeking, and sociability. Associations reached small Cohen's effect sizes for sociability and sensation seeking, but not for aggression–hostility. Associations with neuroticism–anxiety were mostly not significant.Conclusion: The direction of effects confirmed findings from other studies, and the association between changes in personality and alcohol use support the idea that prevention programs should simultaneously target both.
Improved Rehabilitation Outcomes for Persons With and Without Problematic Substance Use After 2 Years With Assertive Community Treatment—A Prospective Study of Patients With Severe Mental Illness in 12 Norwegian ACT Teams
Authors: Clausen Hanne , Ruud Torleif , Odden Sigrun , Benth Jūratė Šaltytė , Heiervang Kristin Sverdvik , Stuen Hanne Kilen , Landheim Anne 
Published: December 2020

Background: Persons with severe mental illness often face difficulties in accessing and receiving adequate services enabling them to live independently. Many have co-occurring substance use problems that increase the risk of adverse outcomes. Community-based service models have been implemented around the world, including assertive community treatment (ACT), but the knowledge of rehabilitation outcomes in different subgroups is limited. We aimed to explore rehabilitation outcomes among patients suffering severe mental illness with and without substance use problems who had received ACT services for at least 2 years. Additionally, we compared differences in changes between the two groups.Methods: A total of 142 patients who received services for 2 years from the first 12 Norwegian ACT teams were included. Eighty-four (59%) had problematic substance use, while 58 (41%) did not. Data regarding housing, activity, symptoms, functioning, and subjective quality of life were collected upon enrollment into ACT and at 2 years of follow-up. Clinician-rated scales and self-report questionnaires were used. Changes within the two groups and differences in change between the groups were assessed using generalized linear mixed models.Results: Both groups were more likely to have good housing, higher level of functioning, and less anxiety and depressive symptoms after 2 years. The odds of good housing among participants with problematic substance use increased only after adjusting for age and gender. Participants with problematic substance use had less severe symptoms, particularly negative and manic symptoms, while participants without problematic substance use reported improved satisfaction with life in general. Neither group experienced a change in having a meaningful daily activity, positive symptoms, practical and social functioning, or subjective quality of life. The reduction of manic symptoms in the substance use group was the only difference between the groups.Conclusion: After 2 years, patients with and without problematic substance use experienced improvements in several important domains. Furthermore, the improvements were similar in both groups for most outcomes. This may suggest that ACT has a place in the continued effort toward integrated and comprehensive community services empowering patients with severe mental illness to achieve and sustain an independent life, including marginalized groups with severe substance use.
Total Intracorporeal Robot Kidney Autotransplantation: Case Report and Description of Surgical Technique
Authors: Van Praet Charles , Lambert Edward , Desender Liesbeth , Van Parys Benjamin , Vanpeteghem Caroline , Decaestecker Karel 
Published: December 2020

Introduction and Objectives: Kidney autotransplantation can be performed in patients with complex renal or ureteral pathology not suitable for in situ reconstruction, such as renal vasculature anomalies, patients with proximal or long complex ureteral strictures, or complex oncological cases. Robot-assisted surgery allows for a high-quality vascular and ureteral anastomosis and faster patient recovery. Robot-assisted kidney autotransplantation (RAKAT) is performed in two phases: nephrectomy and pelvic transplantation. In-between, extraction of the kidney allows for vascular reconstruction or kidney modification on the bench and safe cold ischemia can be established. If no bench reconstruction is needed, total intracorporeal RAKAT (tiRAKAT) is feasible. One case report in Europe has been described; however, to our knowledge no surgical video is available.Methods: A 58 year-old woman suffered from right mid- and distal ureteral stenosis following pelvic radiotherapy 10 years prior for cervical cancer. A JJ stent was placed, but she suffered from recurrent urinary tract infections, and ultimately a nephrostomy was placed. Renogram demonstrated 43% relative right kidney function. As her bladder volume was low following radiotherapy, no Boari flap was possible and the patient refused life-long nephrostomy or nephrectomy. Therefore, tiRAKAT was performed using the DaVinci Xi system.Results: We describe our surgical technique including a video. Surgical time (skin-to-skin) was 5 h and 45 min. Warm ischemia time was 4 min, cold ischemia 55 min, and rewarming ischemia 15 min. The abdominal catheter and bladder catheter were removed on the first and second postoperative day, respectively. The JJ stent was removed after 4 weeks. The patient suffered from pulmonary embolism on the second postoperative day, for which therapeutic low molecular weight heparin was started. No further complications occurred during the first 90 postoperative days. After 7 months, overall kidney function remained stable, right kidney function dropped non-significantly from 27 to 25.2 mL/min (−6.7%) on renal scintigraphy.Conclusion: We demonstrated feasibility and, for the first time, a surgical video of tiRAKAT highlighting patient positioning, trocar placement, and intracorporeal cold ischemia technique.
Effect of Meperidine on Equine Blood Histamine, Tryptase, and Immunoglobulin-E Concentrations
Authors: Trenholme H. Nicole , Sakai Daniel M. , Berghaus Londa J. , Hanafi Amanda L. , Knych Heather K. , Ryan Clare A. , McHale Brittany , Banovic Frane , Quandt Jane E. , Barletta Michele , Reed Rachel A. 
Published: December 2020

Objectives:To evaluate changes in immunological parameters following subcutaneous (SC) and intramuscular (IM) administration of meperidine in horses through quantitative analysis of plasma tryptase, histamine, and IgE levels.Methods:Six adult horses were enrolled in a prospective randomized crossover design. Horses were administered one treatment per day, with a seven day washout period: (a) meperidine 1 mg/kg IM, saline 6 mL SC; (b) saline 6 mL IM, meperidine 1 mg/kg SC; (c) saline 6 mL SC, saline 6 mL IM. Blood samples were obtained for plasmatic histamine (baseline, 5, 10, 15, 30, and 60 min) via LC-MS/MS and plasmatic tryptase (baseline, 15, 30, 60, 120, and 240 min) quantification with enzyme-linked immunoabsorbent assays. Serum immunoglobulin E (IgE) concentrations prior to any meperidine treatment and 7–14 days following the first meperidine treatment were evaluated with enzyme-linked immunoabsorbent assays. Histamine and tryptase concentrations were evaluated with a mixed-effect analysis of variance. The levels of IgE at baseline (before the administration of the first dose of meperidine) were compared with the IgE values at 60 min following the second meperidine administration with the Pairedttest. Biopsies of localized injection site reactions from subcutaneous meperidine administration were collected from two horses.Results:No statistically significant elevations from baseline in histamine (p= 0.595), tryptase (p= 0.836), or IgE (p= 0.844) were found in any of the horses in this study. There were no differences between treatment groups. Administration of SC meperidine caused a localized vasculitis and thrombosis with regional edema and hemorrhage.Conclusion:No evidence of anaphylactoid or anaphylactic type reactions occurred following IM or SC meperidine administration.
Investigating the Chromospheric Footpoints of the Solar Wind
Authors: Bryans Paul , McIntosh Scott W. , Brooks David H. , De Pontieu Bart 
Published: December 2020

Abstract
Coronal holes present the source of the fast solar wind. However, the fast solar wind is not unimodal—there are discrete, but subtle, compositional, velocity, and density structures that differentiate different coronal holes as well as wind streams that originate within one coronal hole. In this Letter we exploit full-disk observational “mosaics” performed by the Interface Region Imaging Spectrograph (IRIS) spacecraft to demonstrate that significant spectral variation exists within the chromospheric plasma of coronal holes. The spectral differences outline the boundaries of some—but not all—coronal holes. In particular, we show that the “peak separation” of the Mg ii h line at 2803 Å illustrates changes in what appear to be open magnetic features within a coronal hole. These observations point to a chromospheric source for the inhomogeneities found in the fast solar wind. These chromospheric signatures can provide additional constraints on magnetic field extrapolations close to the source, potentially on spatial scales smaller than from traditional coronal hole detection methods based on intensity thresholding in the corona. This is of increased importance with the advent of Parker Solar Probe and Solar Orbiter and the ability to accurately establish the connectivity between their in situ measurements and remote sensing observations of the solar atmosphere.
Persistent Emission Properties of SGR J1935+2154 during Its 2020 Active Episode
Authors: Göğüş Ersin , Baring Matthew G. , Kouveliotou Chryssa , Güver Tolga , Lin Lin , Roberts Oliver J. , Younes George , Kaneko Yuki , van der Horst Alexander J. 
Published: December 2020

Abstract
We present detailed spectral and temporal characteristics of the persistent X-ray emission of SGR J1935+2154 based on our XMM-Newton and Chandra observations taken in the aftermath of its 2020 April burst storm, during which hundreds of energetic X-ray bursts were emitted, including one associated with an extraordinary fast radio burst. We clearly detect the pulsed X-ray emission in the XMM-Newton data. An average spin-down rate of 1.6 × 10−11 s s−1 is obtained using our spin period measurement combined with three earlier values reported from the same active episode. Our investigations of the XMM-Newton and Chandra spectra with a variety of phenomenological and physically motivated models concluded that the magnetic field topology of SGR J1935+2154 is most likely highly nondipolar. The spectral models indicate that surface field strengths in somewhat localized regions substantially exceed the polar value of 4.4 × 1014 G inferred from a spin-down torque associated with a rotating magnetic dipole.