bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does maladaptive cardiovagal modulation extend to gastric modulation in women with chronic pelvic pain?
Authors: Williams DeWayne , Muth Eric , Thayer Julian , Chelimsky Thomas , Chelimsky Gisela 
Published: October 2020

AbstractBackgroundWomen with chronic pelvic pain (CPP) have poor cardiovagal modulation. It is unclear whether this finding reflects a broader abnormality across many systems such as gastro‐vagal modulation.AimTo determine if maladaptive cardiovagal activity in females with CPP is accompanied by maladaptive gastric myoelectric activity.MethodsA total of 36 health controls (HC) and 75 CPP underwent supine (10 min), then upright (tilted 70° head up; 30 min), and back to supine (10 min) positions. High‐frequency heart rate variability (HF‐HRV; 0.15‐0.4 Hz) was measured as an index of cardiovagal activity. Cutaneous electrogastrography (EGG) assessed gastric myoelectric activity pre‐ and during‐upright tilt. EGG measures from 16 HC and 31 CPP patients were available for analysis and included relative percentage of gastric activity within the normal (2‐4 cpm) and tachygastria (4–10 cpm) ranges, plus ratio of normal/tachygastria.ResultsHF‐HRV was lower in CPP individuals at all time points (each p < .05). CPP individuals showed lesser decrease in HF‐HRV from supine to upright, and poorer HF‐HRV recovery from upright back to supine (F[1, 106] = 4.62, p = .034). HC showed increase in tachygastria activity (t[15] = −2.09, p = .054) while the CPP group showed no change in tachygastria activity from pre‐upright to upright (t[30] = −0.62, p = .537).ConclusionsIndividuals with CPP going from supine to upright demonstrate an impairment in both tachygastria and the parallel decrement in HRV. These results support the hypothesis of a generalized blunting in the physiological modulation in CPP individuals affecting both cardiovascular and gastric systems.
Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients
Authors: Sagata Noriaki , Kano Shin‐ichi , Ohgidani Masahiro , Inamine Shogo , Sakai Yasunari , Kato Hiroki , Masuda Keiji , Nakahara Takeshi , Nakahara‐Kido Makiko , Ohga Shouichi , Furue Masutaka , Sawa Akira , Kanba Shigenobu , Kato Takahiro A. 
Published: October 2020

AbstractAimNeurofibromatosis type 1 (NF1) is a multifaceted disease, and frequently comorbid with neurodevelopmental disorders such as autism spectrum disorder (ASD) and learning disorder. Dysfunction of adenylyl cyclase (AC) is one of the candidate pathways in abnormal development of neuronal cells in the brain of NF1 patients, while its dynamic abnormalities have not been observed. Direct conversion technology can generate induced‐neuronal (iN) cells directly from human fibroblasts within 2 weeks. Just recently, we have revealed that forskolin, an AC activator, rescues the gene expression pattern of iN cells derived from NF1 patients (NF1‐iN cells). In this microreport, we show the dynamic effect of forskolin on NF1‐iN cells.MethodsiN cells derived from healthy control (HC‐iN cells) and NF1‐iN cells were treated with forskolin (final concentration 10 μM), respectively. Morphological changes of iN cells were captured by inverted microscope with CCD camera every 2 minutes for 90 minutes.ResultsPrior to forskolin treatment, neuron‐like spherical‐form cells were observed in HC‐iN cells, but most NF1‐iN cells were not spherical‐form but flatform. Only 20 minutes after forskolin treatment, the morphology of the iN cells were dramatically changed from flatform to spherical form, especially in NF1‐iN cells.ConclusionThe present pilot data indicate that forskolin or AC activators may have therapeutic effects on the growth of neuronal cells in NF1 patients. Further translational research should be conducted to validate our pilot findings for future drug development of ASD.
High‐Fat and High‐Sucrose Diets Impair Time‐of‐Day Differences in Spatial Working Memory of Male Mice
Authors: Davis Jennifer A. , Paul Jodi R. , McMeekin Laura J. , Nason Shelly R. , Antipenko Jessica P. , Yates Stefani D. , Cowell Rita M. , Habegger Kirk M. , Gamble Karen L. 
Published: October 2020

ObjectiveThis study aimed to investigate both the long‐term and short‐term impacts of high‐fat diets (HFD) or high‐sucrose diets (HSD) on the normal diurnal pattern of cognitive function, protein expression, and the molecular clock in mice.MethodsThis study used both 6‐month and 4‐week feeding strategies by providing male C57BL/6J mice access to either a standard chow, HFD, or HSD. Spatial working memory and synaptic plasticity were assessed both day and night, and hippocampal tissue was measured for changes in NMDA and AMPA receptor subunits (GluN2B, GluA1), as well as molecular clock gene expression.ResultsHFD and HSD both disrupted normal day/night fluctuations in spatial working memory and synaptic plasticity. Mice fed HFD altered their food intake to consume more calories during the day. Both diets disrupted normal hippocampal clock gene expression, and HFD reduced GluN2B levels in hippocampal tissue.ConclusionsTaken together, these results suggest that both HFD and HSD induce a loss of day/night performance in spatial working memory and synaptic plasticity as well as trigger a cascade of changes that include disruption to the hippocampal molecular clock.
SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression
Authors: Shang Wenjing , Wang Yue , Liang Xiuming , Li Tongyu , Shao Wei , Liu Fen , Cui Xiujie , Wang Yuanyuan , Lv Lin , Chai Li , Qu Lingxin , Zheng Lixin , Jia Jihui 
Published: October 2020

AbstractSETDB1 is a histone lysine methyltransferase that has critical roles in cancers. However, its potential role in gastric cancer (GC) remains obscure. Here, we mainly investigate the clinical significance and the possible role of SETDB1 in GC. We find that SETDB1 expression is upregulated in GC tissues and its high‐level expression was a predictor of poor prognosis in patients. Overexpression of SETDB1 promoted cell proliferation and metastasis, while SETDB1 suppression had an opposite effect both in vitro and in vivo. Mechanistically, SETDB1 was shown to interact with ERG to promote the transcription of cyclin D1 (CCND1) and matrix metalloproteinase 9 (MMP9) through binding to their promoter regions. In addition, the expression of SETDB1 was also enhanced by the transcription factor TCF4 at the transcriptional level in GC. Furthermore, SETDB1 expression was found to be induced by Helicobacter pylori (H. pylori) infection in a TCF4‐dependent manner. Taken together, our results indicate that SETDB1 is aberrantly overexpressed in GC and plays key roles in gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9. Our work also suggests that SETDB1 could be a potential oncogenic factor and a therapeutic target for GC. © 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Fabrication, mechanical, and electromagnetic studies of cobalt ferrite based‐epoxy nanocomposites
Authors: Yang Yong , Ali Farman , Said Amir , Ali Nisar , Ahmad Sohrab , Raziq Fazal , Khan Sajid 
Published: October 2020

AbstractControlling the interface, contact of organic‐inorganic materials is necessary for the preparation of high‐performance hybrid nanocomposites. Herein, the cobalt ferrite (CoFe2O4) nanofiller was synthesized via coprecipitation route by the reaction of Fe2 (SO4)3, CoSO4, and triethylene glycol. The obtained CoFe2O4 nanoparticles were thermally treated at 600°C for 5 hours. As prepared, the CoFe2O4 nanoparticles were surface functionalized with 3‐(triethoxysilyl) propylamine (APTES). The modified CoFe2O4 nanoparticles were used as reinforcement during the fabrication of epoxy‐based CoFe2O4 nanocomposite. The synthesized nanofillers and nanocomposites were structurally examined by Fourier transform infrared, X‐ray diffraction analysis, scanning electron microscopy, and thermogravimetric analysis. The effect of nanofiller on surface resistivity, electrical conductivity, and mechanical performance was also investigated. The surface resistivity of EP‐CoFe2O4 nanocomposite decreases with increasing loading concentration of CoFe2O4, while thermal degradation temperatures are improved by 90 K (12.7%) compared to neat EP‐polymer. The mechanical properties, that is, stress‐strain and Young's modulus show an increase of about 60% and 35%, respectively, at 5 wt% CoFe2O4 content. The incredible improvement in the electrical conductivity, mechanical, and thermal stability of EP‐CoFe2O4 up to 5%wt. CoFe2O4 contents are attained due to smaller size and well dispersion of nanofillers in the polymeric matrix. These simultaneous enhancements in properties intend that the EP‐CoFe2O4 nanocomposites can be useful as protective coatings and corrosion‐resistant for a variety of applications
Amphiphilic polymer co‐networks: 32 years old and growing stronger – a perspective
Authors: Patrickios Costas S , Matyjaszewski Krzysztof 
Published: October 2020

AbstractThis brief perspective overviews amphiphilic polymer co‐networks (APCNs), polymeric chemically crosslinked hydrogels also covalently hosting a hydrophobic segment, conferring upon these materials the important property of internal self‐organization in aqueous environments. APCN synthesis is most conveniently accomplished via the random crosslinking copolymerization of a hydrophilic monomer with a hydrophobic macro‐crosslinker, whereas better structures are attained via the end‐linking of amphiphilic linear ABA triblock copolymers or amphiphilic star diblock copolymers. Microphase‐separated morphologies, translucency‐to‐transparency, biocompatibility, low to moderate aqueous swelling, fair mechanical strength and possible stimulus‐responsiveness constitute the main physicochemical properties of APCNs, with their major commercial application being in silicone hydrogel soft contact lenses. Modeling the swelling, morphological and mechanical behavior of these intriguing materials is an area where more progress is necessary in order to improve our understanding of these networks and facilitate the design of next‐generation APCNs. © 2020 Society of Industrial Chemistry
Cancer survivors' experiences with conversations about work‐related issues in the hospital setting
Authors: Zegers Amber D. , Coenen Pieter , van Belzen Mirjam , Engelen Vivian , Richel Carol , Dona Desiree J. S. , van der Beek Allard J. , Duijts Saskia F. A. 
Published: October 2020

AbstractObjectiveEarly access to work‐related psychosocial cancer care can contribute to return to work of cancer survivors. We aimed to explore: (a) the extent to which hospital healthcare professionals conduct conversations about work‐related issues with cancer survivors, (b) whether cancer survivors experience these conversations as helpful, and (c) the possible financial implications for cancer survivors of (not) discussing their work early on.MethodsThe Dutch Federation of Cancer Patient Organizations developed and conducted a cross‐sectional online survey, consisting of 27 items, among cancer survivors in the Netherlands.ResultsIn total, 3500 survivors participated in this study (71% female; mean age (SD) 56 (11) years). Thirty‐two percent reported to have had a conversation about work‐related issues with a healthcare professional in the hospital. Fifty‐four percent indicated that this conversation had been helpful to them. Conversations about work‐related issues took place more frequently with male cancer survivors, those aged 55 years or below, those diagnosed with gynecological, prostate, breast, and hematological or lymphatic cancer, those diagnosed ≤2 years ago, or those who received their last treatment ≤2 years ago. There was no statistically significant association between the occurrence of conversations about work‐related issues and experiencing the financial consequences of cancer and/or its treatment as burdensome.ConclusionsAlthough conversations about work‐related issues are generally experienced as helpful by cancer survivors, early access to work‐related psychosocial cancer care in the hospital setting is not yet systematically offered.
Enhancing the adsorption property of macroporous XAD‐2 resin by nanosecond‐pulsed discharge plasma modification
Authors: Xu Qing‐Nan , Yang De‐Zheng , Wang Hong‐Li , Yuan Hao , Jia Zi‐Xian , Yang Hao , Zhou Xiong‐Feng , Wang Wen‐Chun , Xu Yong , Yan Er‐Yan 
Published: October 2020

AbstractIn this study, a nanosecond‐pulsed discharge plasma is employed to modify the macroporous XAD‐2 resin to improve the adsorption performance of polycyclic aromatic hydrocarbons. After modification, XAD‐2‐20 resin shows great advantage on naphthalene (Nap) adsorption, whose adsorption capacity increased by 80.6% and 43.5% compared with the raw and XAD‐2‐30, respectively. The physiochemical properties of XAD‐2 resin are characterized by scanning electron microscope, N2 adsorption/desorption, X‐ray photoelectron spectroscopy, and Fourier‐transform infrared (FTIR) spectrum. The amount of micro‐mesoporous with a size of 2–3.5 nm are formed and many carbonyl groups (C═O) and ester or carboxylic groups (O–C═O) are introduced on the XAD‐2‐20 surface, and the value of O/C is increased from 14% to 53% compared with the raw resin.
Long‐term nitrogen addition impact on agronomic traits, nitrogen uptake and nitrogen resorption efficiency of wheat in a rainfed region
Authors: Xu Aixia , Li Lingling , Coulter Jeffrey A. , Xie Junhong , Zhang Renzhi , Luo Zhuzhu , Cai Liqun , Liu Chang , Wang Linlin 
Published: October 2020

AbstractNitrogen (N) fertilizer management is one of the most important issues in wheat (Triticum aestivumL.) production. To explore the mechanism of N uptake efficiency (NupE) and N resorption efficiency (NRE) in wheat, this study examined the effects of different N fertilizer application rates (0, 52.5, 105, 157.5, 157.5, and 210 kg N ha−1 yr−1) on crop growth parameters, NupE, NRE, and N use efficiency (NUE). The results of the 2‐yr (2018 and 2019) study showed that the growth of crops was enhanced in high‐N treatments, resulting in higher N concentration in wheat tissues. The 105 kg N ha−1treatment (N105) was the best rate for improving spring wheat yield and NUE, ensuring the highest values of N uptake, evapotranspiration, and leaf NRE. Compared with the non‐N‐fertilized control, N105 increased grain yield and N uptake by 46.90 and 90.54%, respectively; thus, N105 had 16.40% higher NUE, 28.33% higher N utilization efficiency (NutE), and 0.58 kg kg−1greater NupE. Therefore, N uptake and N resorption are of great importance for increasing NUE of wheat, and for improving the sustainability of wheat production in the semi‐arid Loess Plateau of China.
Phytodesalination and chemical and organic conditioners to recover the chemical properties of saline‐sodic soil
Authors: Miranda Márcio Fléquisson Alves , Freire Maria Betânia Galvão dos Santos , Almeida Brivaldo Gomes de , Freire Fernando José , Pessoa Luiz Guilherme Medeiros , Freire Alcione Guimarães 
Published: October 2020

AbstractSemiarid regions’ soils have been degraded by salinization. The use of chemical conditioners makes this management very expensive. As an alternative, organic conditioners can be used with plants adapted to the salts and phytoremediation, such asAtriplex nummulariaLindl. This study aimed to evaluate the use of phytoremediation and chemical and organic conditioners in the recovery of chemical attributes of a saline‐sodic soil in Brazil Northeast. A study was carried out by testingA. nummulariawith the application of chemical (gypsum and anionic polymer) and organic conditioners (bovine and sheep manure), and a control treatment. The experiment was conducted for 18 mo with soil sampling at 6, 12, and 18 mo. The treatments did not modify pH but were effective in reducing the electrical conductivity. All treatments reduced the sodium adsorption ratio and the exchangeable sodium percentage. The use ofA. nummulariaand organic conditioners were as efficient as the use of chemical conditioners to improve soil chemical attributes, suggesting the use of these techniques in the management of soil degradation by salinization. Our study also suggests that local seasonal patterns and physical characteristics of soils influence the effectiveness of Atriplex and conditioners on the extraction and dynamics of salts. Phytoremediation may be complementary to the use of organic conditioners produced on the farm, making management more sustainable.
Diterpenoids: Natural Distribution, Semisynthesis at Room Temperature and Pharmacological Aspects‐A Decade Update
Authors: Majhi Sasadhar 
Published: October 2020

AbstractDiterpenoids are a wide and structurally diverse class of natural products and secondary metabolites obtained from four isoprene units joined in a head‐tail fashion. It has been extensively investigated that a semisynthesis is an essential tool for enhancing the biological activity of starting natural products. Different diterpenoids have been employed as starting materials for the synthesis of bioactive semisynthetic derivatives at room temperature in this review. Energy plays a profound role in chemical transformations. However, according to the sixth principle of green chemistry, the most successful route to save energy is to develop strategies/protocols that are able enough to perform the reactions at ambient temperature. This review is aimed to offer an overview of natural distributions of diterpenoids, design, and semisynthesis of diterpenoids at room temperature, and highlights biological activities of semisynthetic derivatives for the first time from 2010–2019.
Autonomic rejuvenation of cloud applications as a countermeasure to software anomalies
Authors: Di Sanzo Pierangelo , Avresky Dimiter R. , Pellegrini Alessandro 
Published: October 2020

SummaryFailures in computer systems can be often tracked down to software anomalies of various kinds. In many scenarios, it might be difficult, unfeasible, or unprofitable to carry out extensive debugging activity to spot the cause of anomalies and remove them. In other cases, taking corrective actions may led to undesirable service downtime. In this article, we propose an alternative approach to cope with the problem of software anomalies in cloud‐based applications, and we present the design of a distributed autonomic framework that implements our approach. It exploits the elastic capabilities of cloud infrastructures, and relies on machine learning models, proactive rejuvenation techniques, and a new load balancing approach. By putting together all these elements, we show that it is possible to improve both availability and performance of applications deployed to heterogeneous cloud regions and subject to frequent failures. Overall, our study demonstrates the viability of our approach, thus opening the way towards its adoption, and encouraging further studies and practical experiences to evaluate and improve it.
Kakkonto, shosaikoto, Platycodon grandiflorum root, and gypsum (a Japanese original combination drug known as saikatsugekito): Pharmacological review of its activity against viral infections and respiratory inflammatory conditions and a discussion of its applications to COVID‐19
Authors: Arita Ryutaro , Ono Rie , Saito Natsumi , Takayama Shin , Namiki Takao , Ito Takashi , Ishii Tadashi 
Published: October 2020

ABSTRACTAimTraditional Japanese (Kampo) medicine has been used to treat viral infectious diseases. In particular, saikatsugekito (a combination drug of kakkonto, shosaikoto, Platicodon glandiflorum root, and gypsum) has been reported to be useful during the past influenza pandemic. The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has spread worldwide, causing the novel coronavirus disease (COVID‐19) to emerge as a pandemic. In this article, we conducted a literature review on the pharmacological activities of the components present in saikatsugekito against viral infection and respiratory inflammation.MethodsWe searched PubMed and the Cochrane Library for English articles, as well as Ichushi and J‐stage for Japanese articles. Articles published until January 1, 2000 were retrieved using the keywords ‘kakkonto’, ‘shosaikoto’, ‘Platycodon’, and ‘gypsum’. We then extracted articles on basic research investigating viral infections, inflammation, cytokine, the immune response, and lung tissue damage.ResultsWe extracted 28 eligible articles. Kampo medicines have antiviral activities by interfering with the attachment, internalization, replication, progeny virion release, and cell‐to‐cell spreading of single‐strand RNA viruses. They also enhance the immunomodulating activities of the host, including cytokine production, regulation of multiple immune cells, and protection from lung tissue injury. Furthermore, Kampo medicine has been found to regulate body temperature and airway mucin release.ConclusionThe results demonstrated that Kampo medicine has therapeutic activities against single‐strand RNA virus infections and respiratory inflammation, and may also have activities against SARS‐CoV‐2. Further research is required to investigate the activity of Kampo medicines, such as saikatsugekito, against SARS‐CoV‐2.
Higher form symmetries of Argyres-Douglas theories
Authors: Del Zotto Michele , Etxebarria Iñaki García , Hosseini Saghar S. 
Published: October 2020

AbstractWe determine the structure of 1-form symmetries for all 4d$$ \mathcal{N} $$N= 2 theories that have a geometric engineering in terms of type IIB string theory on isolated hypersurface singularities. This is a large class of models, that includes Argyres-Douglas theories and many others. Despite the lack of known gauge theory descriptions for most such theories, we find that the spectrum of 1-form symmetries can be obtained via a careful analysis of the non-commutative behaviour of RR fluxes at infinity in the IIB setup. The final result admits a very compact field theoretical reformulation in terms of the BPS quiver. We illustrate our methods in detail in the case of the ($$ \mathfrak{g},{\mathfrak{g}}^{\prime } $$g,g′) Argyres-Douglas theories found by Cecotti-Neitzke-Vafa. In those cases where$$ \mathcal{N} $$N= 1 gauge theory descriptions have been proposed for theories within this class, we find agreement between the 1-form symmetries of such$$ \mathcal{N} $$N= 1 Lagrangian flows and those of the actual Argyres-Douglas fixed points, thus giving a consistency check for these proposals.
Ohlin-Type Theorem for Convex Set-Valued Maps
Authors: Nikodem Kazimierz , Rajba Teresa 
Published: October 2020

AbstractA counterpart of the Ohlin theorem for convex set-valued maps is proved. An application of this result to obtain some inclusions related to convex set-valued maps in an alternative unified way is presented. In particular counterparts of the Jensen integral and discrete inequalities, the converse Jensen inequality and the Hermite–Hadamard inequalities are obtained.