bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the implementation of PROMs and PREMs in routine clinical care: co-design of tools from the perspective of patients and healthcare professionals
Authors: Amat-Fernandez Clara , Pardo Yolanda , Ferrer Montse , Bosch Guillermo , Lizano-Barrantes Catalina , Briseño-Diaz Renata , Vernet-Tomas Maria , Fumadó Lluís , Beisani Marc , Redondo-Pachón Dolores , Bach-Pascual Anna , Garin Olatz ,   Hospital de Mar Patient-Reported Measures Group, Pont Ángels , Zamora Víctor , Argudo Nuria , Bach Anna , Benaiges David , Castells Xavier , Cecchini Lluis , Chamoun Betty , Hurtado Marta , Hurtado Marta , Noguera Alicia , Pérez-Piñero Maribel , Pérez-Sáez María José , Servitja Sonia , Siles Cristina , Villatoro Montserrat , Chamoun Betty , Valderas Jose Maria 
Published: February 2025

Abstract

Background
Implementation of patient-reported measures (PRMs) is an integral element for patient-centered models; however, there is still hardly any quantitative evidence regarding its impact in routine care settings. The objective of this study was to codesign two concise tools that allow for a standardized and longitudinal assessment of the implementation of PRMs in routine care in terms of acceptability and perceived value from the perspective of both patients and healthcare professionals.

Methods
A list of constructs and items to be presented, separately, to patients and healthcare professionals was created from evidence gathered through a narrative literature review. Focus groups, composed of either patients or healthcare professionals from different chronic conditions, were conducted for the co-design of independent assessments. Once agreement was reached, the content validity was examined in separate consensus meetings.

Results
A total of 10 patients and 10 healthcare professionals participated in the focus groups. After 7 focus groups, the PRMs Implementation Assessment Tool for patients (PRMIAT-P) was developed with 33 items in 9 constructs, and the tool for healthcare professionals (PRMIAT-HP) had 33 items in 16 constructs. Content validity was confirmed for both tools.

Conclusions
The perspective of patients and healthcare professionals regarding the implementation of PRMs in routine care can be evaluated quantitively with the PRMIAT tools. These tools are understandable, concise and comprehensive, and can be used in multiple settings and for different chronic conditions. They have been codesigned as a standard set to facilitate both longitudinal assessments and performing benchmarking among different initiatives.
AZIN1 level is increased in medulloblastoma and correlates with c-Myc activity and tumor phenotype
Authors: Sesen Julie , Martinez Tyra , Busatto Sara , Poluben Larysa , Nassour Hassan , Stone Caroline , Ashok Karthik , Moses Marsha A. , Smith Edward R. , Ghalali Aram 
Published: February 2025

Abstract

Background
AZIN1 is a cell cycle regulator that is upregulated in a variety of cancers. AZIN1 overexpression can induce a more aggressive tumor phenotype via increased binding and resultant inhibition of antizyme. Antizyme is a protein that normally functions as an anti-tumor regulator that facilitates the deactivation of several growth-promoting proteins including c-Myc. MYC plays a critical role in medulloblastoma pathogenesis. Its amplification serves as a defining characteristic of group 3 medulloblastomas, associated with the most aggressive clinical course, greater frequency of metastases, and shorter survival times.

Methods
Medulloblastoma tissues (68 TMA, and 45 fresh tissues, and 31 controls) were stained (fluorescence and immunohistochemical) for AZIN1. Western blotting and ELISA were used to detect the AZIN1 level. Phenotypically aggressive cellular features were measured by increased invasion, colony formation and proliferation. CRISPR-Cas9-mediated AZIN1 knocked-out cells were orthotopically implanted in the cerebellum of nude mice (n = 8/group) with a stereotactic frame. Tumor growth was monitored using the In Vivo Imaging System (IVIS).

Results
Here, we investigated the role of AZIN1 expression in medulloblastoma. We found that overexpression of AZIN1 in medulloblastoma cells induces phenotypically aggressive features. Conducting in vivo studies we found that knocking-out AZIN1 in tumors corresponds with reduced tumor progression and prolonged survival. Clinical specimens are revealing that AZIN1 is highly expressed and directly correlates with MYC amplification status in patients.

Conclusion
These data implicate AZIN1 as a putative regulator of medulloblastoma pathogenesis and suggest that it may have clinical application as both a biomarker and novel therapeutic target.
Mullerian anomalies: revisiting imaging and classification
Authors: Dixit Rashmi , Duggireddy Chitty Suvarna , Pradhan Gaurav Shanker 
Published: February 2025

Abstract
Mullerian duct anomalies (MDA) are a group of uncommon but treatable causes of infertility and pregnancy complications. This review describes the embryology, American Society of Reproductive Medicine (ASRM) classification 2021, and corresponding imaging features of MDA. The three phases of embryological development of Mullerian duct structures are described. The main emphasis is on the ASRM 2021 classification of MDA into nine descriptive categories, while the European Society of Human Reproduction and Embryology and the European Society for Gynecologic Endoscopy (ESHRE/ESGE) classification is also briefly described where necessary. MRI imaging features of MDA along with the acquisition techniques are discussed in detail, as MRI is the ideal imaging modality for MDA diagnosis. In addition, the current role of imaging modalities such as hysterosalpingography and ultrasound including 3D transvaginal ultrasound is also elucidated. The review aims to revisit the MRI imaging features of Mullerian anomalies and reiterates that an accurate description of each anomaly and precise communication with clinicians is the priority rather than rigidly fitting the anomaly into one particular category.

Critical relevance statement
The ASRM 2021 classification of Mullerian anomalies has re-defined the criteria for an arcuate uterus. Radiologists must know of the new classification and imaging features and try to describe each anomaly accurately rather than forcefully fitting an anomaly into a definite category.

Key Points

MDA has an important role in infertility and pregnancy complications.

Knowledge of imaging features helps radiologists aid patient management; MRI is the preferred imaging modality for MDAs.

An accurate MRI-based description of Mullerian anomalies is crucial, avoiding the pitfalls of rigid categorization.

Graphical Abstract
The role of imaging in defining cardiovascular risk to help cancer patient management: a scoping review
Authors: Farì Roberto , Besutti Giulia , Pattacini Pierpaolo , Ligabue Guido , Piroli Francesco , Mantovani Francesca , Navazio Alessandro , Larocca Mario , Pinto Carmine , Giorgi Rossi Paolo , Tarantini Luigi 
Published: February 2025

Abstract

Objective
This scoping review explores the potential role of cancer-staging chest CT scans in assessing cardiovascular (CV) risk in cancer patients. It aims to evaluate: (1) the correlation between non-gated chest CT and the conventional Agatston score from cardiac CT; (2) the association between coronary calcium scores from non-gated chest CT and CV risk in non-oncological patients; (3) the link between coronary calcium assessed by non-gated chest CT and CV events or endothelial damage in cancer patients.

Methods
Three different searches were performed on PubMed, according to the three steps described above. Both original articles and systematic reviews were included.

Results
Many studies in the literature have found a strong correlation between coronary calcium scores from non-gated chest CTs and the conventional Agatston scores from gated cardiac CTs. Various methodologies, including Agatston scoring, ordinal scoring, and the “extent” and “length” methods, have been successfully adapted for use with non-gated chest CTs. Studies show that non-gated scans, even those using iodinated contrast, can accurately assess coronary calcification and predict CV risk, with correlations as high as r = 0.94 when compared to cardiac CTs. In oncological settings, studies demonstrated a significant link between coronary calcium levels on non-gated chest CTs and higher CV risk, including MACE and overall mortality.

Conclusions
Radiological assessment of coronary calcium on non-gated CT scans shows potential for improving CV risk prediction.

Critical relevance statement
Non-gated chest CT scans can detect endothelial damage in cancer patients, highlighting the need for standardized radiological practices to assess CV risks during routine oncological follow-up, thereby enhancing radiology’s role in comprehensive cancer care.

Key Points

Cancer therapies improve outcomes but increase cardiovascular risk, requiring balanced management.

Coronary calcification on non-gated CT correlates with Agatston scores, predicting cardiovascular risk.

Routinely performed CTs predict cardiovascular risk, optimizing the management of cancer patients.

Graphical Abstract
Frequency, phenotypes, and neuroimaging of early post stroke movement disorders: a prospective study
Authors: Samra Eslam , Roushdy Tamer , Zaki Amr S. , Mansour Alia H. , Elbassiouny Ahmed , Shalash Ali 
Published: February 2025

Abstract

Background
A prospective observational study recruited patients with acute stroke. Patients were assessed for the presence of post-stroke movement disorders PSMDs during the first week of stroke. This study aimed to identify the frequency, clinical characteristics, and neuroimaging of early PSMDs (within the first week) and followed for 1 year.

Results
A total of 600 patients were recruited; 21 patients (3.5%) with PSMDs were detected. Thirteen (2.2%) patients presented with intention tremor/ataxia and eight (1.3%) presented with other movement disorders (most commonly, chorea and tremor). One patient presented with periodic left upper limb shaking with right subcortical watershed infarction, and one patient developed palatal myoclonus with right middle cerebral artery infarction. Patients with PSMDs had significantly lower stroke severity (NIHSS) and were more likely to have lacunar strokes (p < 0.001 and < 0.006, respectively) than patients without PSMDs. Early PSMDs were more associated with posterior circulation strokes (84.25%).

Conclusions
Early PSMDs are commonly hyperkinetic, more associated with small vessel disease, and less severe and posterior circulation strokes, implying their clinical importance for the proper management of stroke patients.
Circulant systems can get synchronized with cross-variable coupling
Authors: Shivakumar R. , Shekofteh Yasser , Natiq Hayder , Parastesh Fatemeh , Rajagopal Karthikeyan , Jafari Sajad 
Published: February 2025

Abstract
Diffusive coupling plays a crucial role in numerous applications by facilitating the diffusion of energy or information among systems. Typically, this type of coupling is defined by the same variables in coupled systems. However, this paper demonstrates that in circulant systems, diffusive coupling can be applied to cross variables with cyclical symmetry. This approach results in a unique form of synchronization known as circulant synchronization, occurring among the cross variables. Furthermore, a dynamic analysis reveals that these systems can exhibit various synchronization manifolds, including periodic, quasiperiodic, and chaotic attractors.
Comparative Effects of Carotid Endarterectomy and Stenting on Visual Recovery in Patients With Carotid Artery Stenosis
Authors: Oya Soichi , Yoshida Shinsuke , Saito Akira , Iihoshi Satoshi , Obata Hiroto , Yamasaki Atsushi , Koizumi Takahiro , Shojima Masaaki , Suzuki Kaima , Ooigawa Hidetoshi , Kohyama Shinya , Kikkawa Yuichiro , Kurita Hiroki 
Published: February 2025

BACKGROUND AND OBJECTIVES:
Although carotid endarterectomy (CEA) and carotid artery stenting (CAS) reduce the risk of stroke, their efficacy in improving decreased vision is unclear. This study aims to evaluate the effects of CEA and CAS on ocular blood flow (OBF) and visual acuity (VA) in patients with carotid artery stenosis, while also exploring the possible relevance of postoperative microembolisms to visual recovery.

METHODS:
The results of 78 procedures (CEA, 39; CAS, 39) performed in 76 patients with carotid artery stenosis were prospectively analyzed. OBF was measured using laser speckle flowgraphy to assess the mean blur ratio, which reflects the absolute retinal blood flow. VA was assessed using Contrast Sensitivity Vision-1000, which measures contrast sensitivity, and the area under the log contrast sensitivity function (AULCSF) was calculated as a measure of VA. Microembolisms were evaluated using magnetic resonance imaging immediately after surgery, and their effects on retinal vessels were assessed using optical coherence tomography of the central fovea.

RESULTS:
Both treatments significantly enhanced OBF (MBR: 31.4 to 37.9 [P < .0001] for CEA; 33.9 to 37.8 [P = .007] for CAS). VA improved significantly after CEA (AULCSF: 1.03 to 1.06, P = .02), but not after CAS (1.08 vs 1.06, P = .37). In the analysis of all 78 patients, those with postoperative microembolisms showed poorer visual improvement (AULCSF change 0.01 vs −0.07, P = .01). In addition, among 39 patients assessed with optical coherence tomography, retinal vessel density decreased significantly more after CAS than CEA (−0.5 vs 1.1, P = .04).

CONCLUSION:
Although carotid revascularization can enhance OBF, VA improved only after CEA. Microembolisms appear to impair visual recovery. These findings emphasize the importance of assessing visual function in patients with carotid artery stenosis and the need for personalized treatment approaches based on individual visual profiles and stroke risk.
The Freight Transportation Game: Operational Challenges for Carriers in Online Spot Market Platforms
Authors: Lafkihi Mariam , Pan Shenle , Ballot Eric 
Published: February 2025

In the freight transport spot market, carriers face several challenges, including handling small-sized loads, managing short lead times, and dealing with uncertainties that can disrupt their existing networks and capacity. In this context, auction platforms assist carriers in developing strategies to maintain productivity and service levels. This paper introduces the freight transportation game, an online auction-based platform specifically designed for the freight spot market. The game equips players, acting as carriers, with tools to develop transportation strategies, optimize routes, and propose competitive rates to maximize profits. Players engage in decision making and competition, with key performance indicators evaluating their decisions. The game includes two scenarios; the first helps students understand the operational challenges that carriers face in spot market auctions, whereas the second encourages cooperation to enhance performance and overcome obstacles. Designed for a three-hour session, the game can be integrated into courses on supply chain management or transportation systems. The practical learnings for students from the game include understanding the complexity of constructing transport plans, recognizing the challenges of using online auction-based platforms, and experiencing the difficulties of managing spot market requests despite their benefits. Funding: This work was supported by the Physical Internet Chair at Mines Paris, PSL University funded through an “Appel à Manifestation d’Intérêt” titled “Skills and Jobs of the Future” launched by la Caisse des Dépôts. Supplemental Material: Supplemental materials are available at https://doi.org/10.1287/ited.2024.0091 .
Epithelioid angiosarcoma of the cervical spine: A case report
Authors: Nan Yu-Han , Chiu Cheng-Di , Chen Wei-Liang , Chen Liang-Chi , Chen Chun-Chung , Cho Der-Yang , Guo Jeng-Hung 
Published: February 2025

BACKGROUND
Epithelioid angiosarcoma (EA) is an aggressive, malignant endothelial-cell tumor of vascular or lymphatic origin. EA often arises from deep soft tissues such as pleura, breast, bone and gastrointestinal tract. It usually affects patients aged 60-70 years and is associated with high recurrence and metastasis rates with surgical resection as the primary treatment of choice. Overall survivals are generally poor, ranging from 6 to 16 months. More than 50% of patients died of disease within 2 to 3 years of diagnosis.
CASE SUMMARY
We present a rare case of EA of the cervical spine causing a C6 pathological fracture complicated by severe kyphosis. The patient received C4-7 posterior laminectomy and C2/3/4/7/T1 transpedicular screw fixation, followed by anterior C5-6 corpectomy with allograft bone fusion and cervical plate fixation. Postoperative radiotherapy was administered without delay. However, the patient died of rapidly progressive acute respiratory distress syndrome 3 weeks after the second surgery.
CONCLUSION
EA with spinal involvement is extremely rare. Early detection and cord decompression may prevent neurological deterioration and preserve better quality of life.
A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (X842) and Lansoprazole for the Treatment of Patients With Erosive Esophagitis
Authors: Zhu Siying , Han Muzhou , Zong Ye , Meng Fandong , Liu Qi , Tuo Biguang , Zhang Zhenyu , Wang Qizhi , Liu Xiaowei , He Song , Zhen Yanbo , Shao Dong , Wang Shenglan , Xu Baohong , Li Xing , Tang Haitao , Miu Yangde , Liu Chengxia , Hu Jiuye , Hu Pingsheng , Xiu Jin , Lu Ming , Wu Yongdong , Zhang Shutian 
Published: February 2025

INTRODUCTION:
X842 is a new type of gastric acid-suppressing agent with a rapid onset of action and a long duration of effect. We aim to investigate the efficacy and safety of different doses of X842 vs lansoprazole in the treatment of patients with erosive esophagitis (EE).

METHODS:
This phase 2 study included 90 patients with EE (Los Angeles grades A–D) who were randomized (1:1:1) to receive oral low-dose X842 (50 mg/d, n = 31), high-dose X842 (100 mg/d, n = 31), or lansoprazole (30 mg/d, n = 30) for 4 weeks. The main efficacy end point was the EE healing rate, which was the proportion of patients who achieved endoscopic healing after 4 weeks of treatment.

RESULTS:
For intention-to-treat analysis, the EE healing rates at 4 weeks were 93.6% (29/31), 79.3% (23/29), and 80.0% (24/30) for the X842 50 mg, the X842 100 mg, and the lansoprazole 30 mg groups. For per-protocol analysis, the EE healing rates at 4 weeks were 93.6% (29/31), 80.8% (21/26), and 82.1% (23/28) in the 3 groups, respectively. The EE healing rate did not significantly differ among the 3 groups in either the intention-to-treat (P = 0.2351) or per-protocol (P = 0.3320) analysis. The incidence of drug-related treatment-emergent adverse events did not differ among groups. No severe drug-related treatment-emergent adverse events occurred in the X842 group.

DISCUSSION:
Our findings confirmed that X842 had efficacy and a favorable safety profile similar to those of lansoprazole. Therefore, X842, a novel potassium-competitive acid blocker, is expected to become a promising therapeutic agent for EE.
The first experience with the use of ofatumumab for the treatment of pediatric multiple sclerosis in real-life clinical practice in Russia. A case series
Authors: Kuzminykh E. D. , Lebedev V. M. , Senchenko V. E. , Cherepyansky M. S. , Gonchar V. A. , Korobko D. S. 
Published: February 2025

In recent years, the incidence of multiple sclerosis (MS) has increased in the pediatric population. As there are no separate clinical guidelines for the treatment of pediatric MS and therapeutic options have expanded, it is important to discuss and establish new protocols for the treatment of MS in children and adolescents. This article presents a series of clinical cases of the use of ofatumumab in patients under 18 years of age with a relapsing-remitting MS (RRMS).In the first observation, a 16-year-old female patient with RRMS was switched to ofatumumab therapy due to persistent clinical and radiological activity of the disease during dimethyl fumarate therapy. After the first injection, hyperthermia of up to 38.6 °C and cephalgia were observed, which resolved on the background of symptomatic therapy. No adverse events occurred with subsequent injections, and the patient had clinical and radiological remission during the six-month use of the drug.In the second observation, a 17-year-old female patient with a four-year history of the disease showed resistance to first-line therapy (interferon β1a and glatiramer acetate), so therapy was switched to ofatumumab. After the first injection, persistent hyperthermia of up to 39.3 °C was observed for two days, therefore, premedication with antipyretic and antihistamine medication was performed for the next two injections. No further adverse events were recorded, the therapy was well tolerated, and premedication was not required. The clinical remission of the disease lasted for six months and the results of the control MRI showed no signs of disease activity.In the third observation, ofatumumab therapy was initiated in a 17-year-old patient with rapidly progressive MS. No adverse events were recorded during the 9-month treatment, no signs of the disease activity were detected on the control MRI, and a decrease in the size of some foci was observed. Thus, high short-term efficacy, good tolerability and safety of ofatumumab in the treatment of MS in patients under 18 years of age were demonstrated, which are consistent with the results of the use of the drug in the adult population; no unexpected adverse events were observed. The subcutaneous route of administration contributed to improved patients’ adherence to therapy.
Lipid metabolism in overweight/obese children vs. normal weight children in a north-eastern region of Spain
Authors: Cuenca Alcocel José , Villalba-Heredia Lorena , Martínez Redondo Inés , Gallego Royo Alba , Casajús José A. , Arbonés-Mainar José M. , Calmarza Pilar 
Published: February 2025

Abstract

Objectives
Obesity and overweight have increased in children and adolescents in Europe in the recent years, accounting for a major global public health problem. The objective of this study was the early detection of metabolic abnormalities in overweight/obese children (8–12 years old) that may ultimately induce impaired glucose metabolism and/or cardiovascular diseases.

Methods
Lipid metabolism and metabolic control parameters were measured and monitored in a group of 61 male and female children with overweight/obesity and a group of 45 healthy, normal weight children, comparing the results obtained. Ages ranged from 8 to 12 years.

Results
Higher levels of triglycerides and insulin and lower levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 were observed in overweight/obese children, as compared to normal weight children. Overweight/obese children exhibited higher apolipoprotein B/apolipoprotein A1 ratio, triglyceride-glucose ratio and HOMA index and a lower low-density lipoprotein (LDL) cholesterol/apolipoprotein B ratio.

Conclusions
Obesity at an early age (8–12 years) negatively affects lipid parameters. Hence, overweight/obese children presented a more atherogenic lipid profile, manifested as higher concentrations of remnant particles and small dense LDL particles, higher insulin resistance and a higher risk for developing diabetes mellitus type 2 and cardiovascular disease, as compared to normal weight children.