bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to improve the process of forming biobased R&D collaborations
Authors: Israël‐Hoevelaken Brenda T.P.M. , Wubben Emiel F.M. , Bos Harriëtte L. , Wijffels René H. , Omta Onno S.W.F. 
Published: June 2020

AbstractThe transition towards a biobased economy requires innovations. In addition to the usual challenges of innovation trajectories, the characteristics of biobased innovations cause extra difficulties. To lower the failure rate of innovation trajectories in general, companies tend to form R&D collaborations. Choices made during the formation of such R&D collaborations play a key role in the project's success. Here, one may benefit from the social sciences. This paper presents a perspective on what the social sciences may bring to analyze and improve the formation process of biobased R&D collaborations. The paper also provides an overview of relevant innovation and transition models, and lists the dominant variables in such formation processes (biobased characteristics and general determinants), and the guidelines that seem useful. Although each model has its advantages, none of the innovation and transition models studied addresses both thephases of a formation processof a biobased R&D collaboration and thevariablesinvolved in each phase. Concerning the formation process of biobased R&D collaborations, the literature addresses social, organizational, technological, economic, and environmental variables. The key determinants of multi‐partner R&D collaborations are partner properties, motives to join a consortium, appropriability of a firm, and project properties. The descriptions of their influence on an R&D collaboration presented here can be used as guidelines, as recommendations, in processes for the formation of relatively less complex R&D collaborations. The influence of biobased characteristics – such as type of innovation (drop‐ins versus novel materials), biorefinery, biomass supply and technological challenges – on R&D collaboration have not been studied systematically as yet. © 2020 The Authors. Biofuels, Bioproducts, and Biorefining published by Society of Chemical Industry and John Wiley & Sons, Ltd
Simultaneous determination and determination of sildenafil and its active metabolite in human plasma using LC–MS/MS method
Authors: Li Lin‐ling , Zhang Xiu‐jin , Zheng Chao , Fan Ming‐xia , Xu Hao‐yun , Yi Jin‐ling , Feng Yan , Luo Xi , Li Wei‐hua , Cheng Ze‐neng 
Published: June 2020

AbstractA sensitive and selective high‐performance liquid chromatography–tandam mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous quantification of sildenafil and its metabolite N‐desmethyl sildenafil in human plasma. Sildenafil‐d8 was used as an internal standard. The analytes were extracted by precipitation extraction and chromatographed on a C18 column using mobile phase A of water (containing 0.1% formic acid) and mobile phase B of acetonitrile (containing 0.1% formic acid) with gradient elution. Quantification was done using multiple reaction monitoring mode to monitor the precursor‐to‐product ion transitions of m/z 475.4 → m/z 283.3 for sildenafil, m/z 461.4 → m/z 283.2 for N‐desmethyl sildenafil and m/z 483.3 → m/z 108.1 for IS in positive ionization mode. The calibration curve was established over the range of 2.00–1,000 ng/ml and the correlation coefficient was >0.99. The intra‐day and inter‐day relative standard deviations were <6.5% for sildenafil and 6.3% for N‐desmethyl sildenafil respectively. Accuracy determinaed at four concentrations was 86.50–105.67% for sildenafil and 96.83–114.40% for N‐desmethyl sildenafil. This method was successfully applied to a pharmacokinetic description of sildenafil and the effect of food intake on the pharmacokinetics of sildenafil was also demonstrated in healthy Chinese volunteers.
The role of human sustainability in professional service firms. Evidence from Italy
Authors: Massaro Maurizio , Bagnoli Carlo , Dal Mas Francesca 
Published: June 2020

AbstractSustainability is a central topic for an increasing number of companies, as a part of their business strategies. Human sustainability, that is, preserving and improving the quality of human life, in other words, maintaining and advancing human capital, appears as one relevant issue in that context. Humans and human capital are the foremost resources for professional service firms. Their role in the international economic scenario will most likely depend on how they deal with human sustainability and the wellbeing of their people. In this perspective, the paper investigates the antecedents, and organisational implications, of human sustainability in such firms using a structural equation model (SEM) developed on 4,301 questionnaires filled by Italian Chartered Accountants. Findings shed new lights on some implications of human sustainability. Results show that human sustainability has a direct and significative impact on a firm's ability to innovate, fostering creativity and intellectual capital, thus being significant for corporate performance. As a practical implication, firms should accordingly shape their business strategies towards accounting for human sustainability aspects.
In the LEED: Racing to the Top in Environmental Self‐Regulation
Authors: Flowers Mallory Elise , Matisoff Daniel C. , Noonan Douglas S. 
Published: June 2020

AbstractDoes voluntary participation in eco‐certification become more substantive over time, or less? Although past research on voluntary programs suggests that later participants are more likely to greenwash by only symbolically adopting voluntary standards, theories of regulatory competition suggest a possible “race to the top.” We argue that participation in voluntary programs can facilitate competition that enables a race, and we advance a theory of self‐regulatory competition to explain dynamics of participation in voluntary environmental programs. Under this perspective, environmental self‐regulation may facilitate a race to the top, despite possibilities for purely symbolic adoption. Analyzing data from a voluntary green building certification program in the United States, we introduce a methodology to distinguish propensities for symbolic certification from more substantive environmental performance. Data demonstrate that later adopters invest additional resources to attain higher certification, becoming greener and suggesting a race to the top in a voluntary greenbuilding certification program.
Design science research for learning software engineering and computational thinking: Four cases
Authors: Apiola Mikko , Sutinen Erkki 
Published: June 2020

AbstractThis study proposes design science research (DSR) as a relevant framework for computational thinking, software engineering, and science, technology, engineering, arts and mathematics integration in higher education. We present four concrete case examples, where DSR has been applied in projects that consist of interdisciplinary teams, which learn by designing solutions for pressing real‐world problems. Our results show that DSR is a potent framework for learning to tackle pressing and wicked problems, and connecting technology projects with research methodology and knowledge from other fields. Our results also show multiple learning gains, including creativity, communication, critical thinking and collaboration. Based on our case analysis, we recommend more extensive use of DSR in future technology curricula.
AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer
Authors: Zhou Jiatong , He Zhaowei , Ma Shenfei , Liu Ranlu 
Published: June 2020

AbstractBackgroundTo investigate the effect of serum aspartate transaminase/alanine transaminase (AST/ALT) on the risk of prostate cancer.MethodsA total of 404 patients undergoing prostate biopsy from April 2016 to July 2019 were enrolled. One hundred and ninety‐four patients with prostatic cancer (PCa) were diagnosed by pathology. Two hundred and ten patients were diagnosed with benign prostatic hyperplasia (BPH). Multivariate logistic regression was used to analyze the effect of AST/ALT ratio and other factors on the incidence of PCa.ResultAST/ALT ratio was significantly higher in PCa than in BPH patients (OR 2.313, 95%CI 1.337‐4.003, P = .002). ROC curve indicated that the best cutoff was 1.155 in predicting the incidence risk of PCa. The age of PCa patients is higher than BPH patients (OR 1.054, 95%CI 1.027‐1.082, P < .001). We also found that platelets were lower in PCa than in BPH patients. Multivariate analysis showed that AST/ALT ratio could be used as an independent predictor to assess the incident risk of PCa(OR 1.043, 95%CI 1.014‐1.072, P = .003). However, AST/ALT ratio did not predict the incidence in high‐risk or low‐risk PCa.ConclusionAST/ALT ratio was an independent factor in predicting the incidence of PCa. When the level of AST/ALT ratio in serum raised, the incidence risk of PCa was significantly increased, which was helpful for the clinical diagnosis of PCa. We still needed a multicenter study to verify the role of AST/ALT ratio in the development of PCa.
Recent Advances on Marine Alkaloids from Sponges
Authors: Bian Changhao , Wang Jiangming , Zhou Xinyi , Wu Wenhui , Guo Ruihua 
Published: June 2020

AbstractAlkaloids from marine secondary metabolites have received extensive attention from pharmacists in recent years. Miscellaneous alkaloids derived from marine sponges possessed various pharmacological activities including cytotoxicity, antimicrobial, antioxidant, and so on. Herein, we summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020 and analyzed the production environment of marine sponges with rich alkaloids. Moreover, we discussed biosynthesis routes of pyrrole and guanidine alkaloids from marine sponges Agelas and Monanchora. This article will be beneficial for future research on drugs from marine natural products.
Resting Pd/Pa correlates with fractional flow reserve but not angiographic severity in calcified coronary arteries
Authors: Sattler Megan , Moscona John , Johnson Paul M. , Madamanchi Chaitanya , Rossi Joseph S. , Stouffer George A. 
Published: June 2020

AbstractObjectiveStudy the effect of coronary artery calcium (CAC) on resting coronary physiological indices.BackgroundPrior studies found no correlation between angiographic stenosis and fractional flow reserve (FFR) in heavily calcified arteries.MethodsTwo hundred consecutive patients undergoing whole‐cycle resting Pd/Pa and FFR evaluation of a single lesion of intermediate severity (40–80%) had CAC quantified based upon radiopacities at the site of the stenosis, where 0 = none or mild calcium, 1 = moderate calcium, and 2 = severe calcium.ResultsMean age was 61 ± 11 years and 34% were female. The mean degree of stenosis, FFR, and resting Pd/Pa were 60 ± 12%, 0.83 ± 0.08, and 0.93 ± 0.05, respectively. Resting Pd/Pa correlated with degree of angiographic diameter stenosis (DS) as determined by quantitative coronary angiography (QCA) or visual estimation in arteries with calcium score of 0 or 1, but there was no correlation in severely calcified arteries. The diagnostic accuracy of DS ≥70% by QCA to predict hemodynamic significance was 68% with calcium scores of 0/1, but only 43% with calcium score = 2. Resting Pd/Pa was highly correlated with FFR irrespective of the degree of CAC (R2 = 0.68, p < .001) and the sensitivity of resting Pd/Pa ≤0.91 for predicting an FFR ≤0.80 was 0.67 in arteries with calcium scores of 0 or 1 and 0.69 in arteries with a calcium score of 2.ConclusionsThere was no correlation between angiographic stenosis and either resting Pd/Pa or FFR in heavily calcified coronary artery lesions.
Noninvasive prenatal testing detected acute myeloid leukemia in paucisymptomatic pregnant patient
Authors: Rengifo Laura Yissel , Michaux Lucienne , Maertens Johan , Tousseyn Thomas , Lenaerts Liesbeth , Vermeesch Joris Robert , Vandenberghe Peter , Dewaele Barbara 
Published: June 2020

AbstractTo the authors' best knowledge, this is the first report of acute myeloid leukemia (AML) detected by noninvasive prenatal testing. This was an aggressive case that otherwise would have been difficult to characterize due to disadvantages of "gold‐standard" techniques.
Electrospun Polyacrylonitrile‐Derived Co or Fe Containing Nanofibre Catalysts for Oxygen Reduction Reaction at the Alkaline Membrane Fuel Cell Cathode
Authors: Mooste Marek , Kibena‐Põldsepp Elo , Vassiljeva Viktoria , Kikas Arvo , Käärik Maike , Kozlova Jekaterina , Kisand Vambola , Külaviir Marian , Cavaliere Sara , Leis Jaan , Krumme Andres , Sammelselg Väino , Holdcroft Steven , Tammeveski Kaido 
Published: June 2020

AbstractElectrospun polyacrylonitrile (PAN) based carbon nanofibres (CNF) are employed as cathode catalysts in anion‐exchange membrane fuel cell (AEMFC) for the first time. The catalysts are prepared via pyrolysis of Co or Fe salt‐containing PAN fibre with and without the ionic liquid (IL) additive. The catalyst material preparation is optimised by assessing the oxygen reduction reaction (ORR) activity of different transition metal and nitrogen‐doped CNFs in 0.1 M KOH by rotating disc electrode method followed by testing in real AEMFC configuration. The best performance in the AEMFC is observed in case of Fe and IL containing PAN fibre that was pyrolysed at 1000 °C and additionally treated in an acid solution (Fe/IL‐PAN‐A1000). In the AEMFC, the Fe/IL‐PAN‐A1000 catalyst showed the maximum power density (Pmax) of 289 mW cm−2, which is 82 % of the Pmax obtained with commercial Pt/C cathode catalyst (352 mW cm−2).
3D Printed Palladium Catalyst for Suzuki‐Miyaura Cross‐coupling Reactions
Authors: Bulatov Evgeny , Lahtinen Elmeri , Kivijärvi Lauri , Hey‐Hawkins Evamarie , Haukka Matti 
Published: June 2020

AbstractSelective laser sintering (SLS) 3d printing was utilized to manufacture a solid catalyst for Suzuki‐Miyaura cross‐coupling reactions from polypropylene as a base material and palladium nanoparticles on silica (SilicaCat Pd0 R815‐100 by SiliCycle) as the catalytically active additive. The 3d printed catalyst showed similar activity to that of the pristine powdery commercial catalyst, but with improved practical recoverability and reduced leaching of palladium into solution. Recycling of the printed catalyst led to increase of the induction period of the reactions, attributed to the pseudo‐homogeneous catalysis. The reaction is initiated by oxidative addition of aryl iodide to palladium nanoparticles, resulting in formation of soluble molecular species, which then act as the homogeneous catalyst. SLS 3d printing improves handling, overall practicality and recyclability of the catalyst without altering the chemical behaviour of the active component.
High‐Voltage Nickel‐Rich NMC Cathode Material with Ionic‐Liquid‐Based Polymer Electrolytes for Rechargeable Lithium‐Metal Batteries
Authors: Gupta Himani , Singh Rajendra Kumar 
Published: June 2020

AbstractIn lithium batteries, high‐nickel‐content layered oxide cathode materials are gaining much attention due to their high capacity and energy density. Therefore, in the present study, a LiNi0.8Mn0.1Co0.1O2 (NMC811) cathode material is synthesized successfully. But, these Ni‐rich cathode materials cannot be operated at high voltage with liquid electrolytes, as they give rise to some problems such as structural instability, high reactivity with electrolyte, electrochemical and thermal instability, and so forth. To suppress these problems, the synthesized ionic‐liquid‐based polymer electrolyte is used over liquid electrolyte as it reduces surface reactivity, enhances cyclic stability and, since it is sufficiently mechanically stable, helps to suppress lithium dendrites growth. Owing to the high electrochemical stability of polymer electrolytes, the performance of the Li battery is also tested at high voltage (4.8 V) and the electrochemical performances are compared at higher and lower cut‐off voltages. The Li battery provides a good capacity (164 mAh.g−1 at C/10) and energy density (611 mWh.g−1) at 4.8 V. In addition, the cyclability of the polymer‐based Li battery is higher, as compared to the liquid‐electrolyte‐based battery. Using the optimized polymer electrolyte, an enhanced structural and interfacial stability of the Li anode and the NMC cathode can be achieved.
Cardiovascular manifestations in severe and critical patients with COVID‐19
Authors: Chen Qingxing , Xu Lili , Dai Yongbin , Ling Yunlong , Mao Jiahao , Qian Juying , Zhu Wenqing , Di Wencheng , Ge Junbo 
Published: June 2020

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) could cause virulent infection leading to Corona Virus Disease 2019 (COVID‐19)‐related pneumonia as well as multiple organ injuries.HypothesisCOVID‐19 infection may result in cardiovascular manifestations leading to worse clinical outcome.MethodsFifty four severe and critical patients with confirmed COVID‐19 were enrolled. Risk factors predicting the severity of COVID‐19 were analyzed.ResultsOf the 54 patients (56.1 ± 13.5 years old, 66.7% male) with COVID‐19, 39 were diagnosed as severe and 15 as critical cases. The occurrence of diabetes, the level of D‐dimer, inflammatory and cardiac markers in critical cases were significantly higher. Troponin I (TnI) elevation occurred in 42.6% of all the severe and critical patients. Three patients experienced hypotension at admission and were all diagnosed as critical cases consequently. Hypotension was found in one severe case and seven critical cases during hospitalization. Sinus tachycardia is the most common type of arrythmia and was observed in 23 severe patients and all the critical patients. Atrioventricular block and ventricular tachycardia were observed in critical patients at end stage while bradycardia and atrial fibrillation were less common. Mild pericardial effusion was observed in one severe case and five critical cases. Three critical cases suffered new onset of heart failure. Hypotension during treatment, severe myocardial injury and pericardial effusion were independent risk factors predicting the critical status of COVID‐19 infection.ConclusionThis study has systemically observed the impact of COVID‐19 on cardiovascular system, including myocardial injury, blood pressure, arrythmia and cardiac function in severe and critical cases. Monitoring of vital signs and cardiac function of COVID‐19 patients and applying potential interventions especially for those with hypotension during treatment, severe myocardial injury or pericardial effusion, is of vital importance.
Ethnic differences in quality of life and its association with survival in patients with heart failure
Authors: Stein Gillian , Teng Tiew‐Hwa K. , Tay Wan T. , Richards A. Mark , Doughty Robert , Dong YanHong , Sim David , Yeo Poh S. D. , Jaufeerally Fazlur , Leong Gerard , Soon Dinna , Ling Lieng H. , Lam Carolyn S. P. 
Published: June 2020

AbstractBackgroundOptimizing quality of life (QoL) is a key priority in the management of heart failure (HF).HypothesisTo investigate ethnic differences in QoL and its association with 1‐year survival among patients with HF.MethodsA prospective nationwide cohort (n = 1070, mean age: 62 years, 24.5% women) of Chinese (62.3%), Malay (26.7%) and Indian (10.9%) ethnicities from Singapore, QoL was assessed using the Minnesota Living with HF Questionnaire (MLHFQ) at baseline and 6 months. Patients were followed for all‐cause mortality.ResultsAt baseline, Chinese had a lower (better) mean MLHFQ total score (29.1 ± 21.6) vs Malays (38.5 ± 23.9) and Indians (41.7 ± 24.5); P < .001. NYHA class was the strongest independent predictor of MLHFQ scores (12.7 increment for class III/IV vs I/II; P < .001). After multivariable adjustment (including NT‐proBNP levels, medications), ethnicity remained an independent predictor of QoL (P < .001). Crude 1‐year mortality in the overall cohort was 16.5%. A 10‐point increase of the physical component (of MLHFQ) was associated with a hazard (HR 1.22, 95% 1.03‐1.43) of 1‐year mortality (P = .018) in the overall cohort. An interaction between MLHFQ and ethnicity was found (P = .019), where poor MLHFQ score (per 10‐point increase) predicted higher adjusted mortality only in Chinese (total score: HR 1.18 [95% CI 1.07‐1.30]; physical: HR 1.44 [95% CI 1.17‐1.75]; emotional score: HR 1.45 [95% CI 1.05‐2.00]).ConclusionsEthnicity is an independent determinant of QoL in HF. Despite better baseline QoL in Chinese, QoL was more strongly related to survival in Chinese vs Malays and Indians. These findings have implications for HF trials that use patient‐reported outcomes as endpoints.
Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population
Authors: Lewis Joshua P. , Riaz Moeen , Xie Sophia , Polekhina Galina , Wolfe Rory , Nelson Mark , Tonkin Andrew M. , Reid Christopher M. , Murray Anne M. , McNeil John J. , Shuldiner Alan R. , Lacaze Paul 
Published: June 2020

The platelet endothelial aggregation receptor‐1 (PEAR1) rs12041331 variant has been identified as a genetic determinant of platelet aggregation in response to antiplatelet therapies, including aspirin. However, association with atherothrombotic cardiovascular events is less clear, with limited evidence from large trials. Here, we tested association of rs12041331 with cardiovascular events and aspirin use in a randomized trial population of healthy older individuals. We undertook post hoc analysis of 13,547 participants of the ASPirin in Reducing Events in the Elderly (ASPREE) trial, median age 74 years. Participants had no previous diagnosis of atherothrombotic cardiovascular disease at enrollment, and were randomized to either 100 mg daily low‐dose aspirin or placebo for median 4.7 years follow‐up. We used Cox proportional hazard regression to model the relationship between rs12041331 and the ASPREE primary cardiovascular disease (CVD) end point, and composites of major adverse cardiovascular events (MACE) and ischemic stroke (STROKE); and bleeding events; major hemorrhage (MHEM) and intracranial bleeding (ICB). We performed whole‐population analysis using additive and dominant inheritance models, then stratified by treatment group. Interaction effects between genotypes and treatment group were examined. We observed no statistically significant association (P < 0.05) in the population, or by treatment group, between rs12041331 and cardiovascular or bleeding events in either model. We also found no significant interaction effects between rs12041331‐A and treatment group, for CVD (P = 0.65), MACE (P = 0.32), STROKE (P = 0.56), MHEM (P = 0.59), or ICB (P = 0.56). The genetic variant PEAR1 rs12041331 is not associated with cardiovascular events in response to low‐dose aspirin in a healthy elderly population.
Electrostatic solitary waves associated with relativistic nonextensive electrons in magnetized fusion plasma
Authors: Motevalli S. Mohammad , Dashtban Noushin 
Published: June 2020

AbstractProperties of nonlinear electrostatic solitary waves in a magnetized multicomponent system of plasma containing of warm fluid ions, weakly relativistic warm fluid electrons and q‐nonextensive distributed electrons using reductive perturbation method, have been surveyed. For this purpose, a KdV soliton type solution has been employed. The dependence of solitary wave structure, solitary wave maximum amplitude, and phase velocity of soliton on the plasma parameters is defined numerically.