bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disinfection of corona virus in histopathology laboratories
Authors: Luqman Zubair , Iqbal Nasir , Ali Hafiz Muhammad , Zahid Muhammad , Sikandar Arbab , Kausar Razia 
Published: June 2020

AbstractSevere acute respiratory syndrome (SARS CoV‐2/COVID‐19) is a highly contagious and deadly disease caused by a virus belonging to the coronaviridae family. Researchers working in histopathology laboratories, dealing with morbid samples, are particularly vulnerable to infection unless they have very strong immunity. Hence, a proper precautionary protocol is required for the safety of the laboratory staff. The current review highlights the biological and physical agents that can be used to inactivate the virus and disinfect the surrounding environment in the laboratory.
Optimizing self‐expandable transcatheter heart valve sizing in patients with small sinus of Valsalva
Authors: Sakai Katsuaki , Ohno Yohei , Miyamoto Junichi , Horinouchi Hitomi , Murakami Tsutomu , Okada Kimiaki , Cho Yasunori , Ito Kenji , Nakazawa Gaku , Ikari Yuji 
Published: June 2020

AbstractObjectivesTo evaluate the feasibility and efficacy of transcatheter aortic valve replacement (TAVR) in patients with small sinus of Valsalva (SOV).BackgroundPatients with small SOV are considered unfavorable for TAVR since it carries risk of coronary obstruction after valve implantation. Therefore, these patients with small SOV were excluded from previous clinical trials.MethodsBetween February 2017 and February 2019, a total of 139 consecutive patients with severe aortic stenosis (AS) undergoing TAVR were prospectively enrolled in the Tokai Valve Registry. Patients with small SOV who were treated with smaller size of self‐expandable transcatheter heart valve (THV) than expected by perimeter‐based sizing were included in this study. Eleven patients (7.9%) were included.ResultsMean age was 86.5 ± 3.8 years and median STS Score was 8.5% (interquartile range: 6.3–12.3%). Device success was accomplished in all patients and no coronary obstruction was observed. No moderate/severe paravalvular leakage, new onset conduction disturbance, and new permanent pacemaker implantation were noted. At 30‐day follow‐up, mean aortic valve gradient was 6.9 ± 1.7 mmHg and mean indexed aortic valve area was 0.95 ± 0.16 cm2/m2. Prosthetic valve performance was stable at 12‐month follow‐up. No severe prosthesis patient mismatch was documented at any time point. No in‐hospital, 30‐day, and 12‐month mortality were observed. The median follow‐up was 711 days (IQR: 547–803 days), and no patient was lost to follow‐up.ConclusionsOur preliminary experience suggests favorable safety and efficacy of TAVR utilizing self‐expandable THV with intentional down‐sizing in patients with severe AS and small SOV in a mid‐term follow‐up.
Efficacy of lenalidomide in myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and an extreme platelet count
Authors: Divoux Marion , Plocque Alexia , Sevin Margaux , Voillat Laurent , Feugier Pierre , Guerci‐Bresler Agnès , Girodon Francois , Broséus Julien 
Published: June 2020

AbstractLenalidomide is efficient in reducing red blood cell transfusion dependency and markedly lowering platelet counts in MDS/MPN‐RS‐T in the context of major platelet counts.
Photoredox Organic Synthesis Employing Heterogeneous Photocatalysts with Emphasis on Halide Perovskite
Authors: Lin Yixiong , Guo Jun , San Martin Jovan , Han Chuang , Martinez Ramon , Yan Yong 
Published: June 2020

AbstractLately, heterogeneous semiconductor materials have been explored as an emerging type of efficient photocatalyst for photoredox organic synthesis. Among these semiconductors, lead halide perovskite materials demonstrate unique properties towards excellent charge separation and charge transfer, extremely long charge carrier migration, high efficiency in visible light absorption, and long excited states lifetimes, etc., as proved in ground‐breaking solar cell applications, garnering necessary merits for an efficient catalytic system for photoredox organic reactions. Here, the latest progress in heterogeneous semiconductor materials towards this endeavor is examined, with particular emphasis on lead halide perovskite nanocrystals (NCs) in photocatalytic organic synthesis.
Photoinduced Strain‐Assisted Synthesis of a Stiff‐Stilbene Polymer by Ring‐Opening Metathesis Polymerization
Authors: Krishnan Baiju P. , Xue Lulu , Xiong Xinhong , Cui Jiaxi 
Published: June 2020

AbstractDeveloping a novel strategy to synthesize photoresponsive polymers is of significance owing to their potential applications. We report a photoinduced strain‐assisted synthesis of main‐chain stiff‐stilbene polymers by using ring‐opening metathesis polymerization (ROMP), activating a macrocyclic π‐bond connected to a stiff‐stilbene photoswitch through a linker. Since the linker acts as an external constraint, the photoisomerization to the E‐form leads to the stiff‐stilbene being strained and thus reactive to ROMP. The photoisomerization of Z‐form to E‐form was investigated using time‐dependent NMR studies and UV/Vis spectroscopy. The DFT calculation showed that the E‐form was less stable due to a lack of planarity. By the internal strain developed due to the linker constraint through photoisomerization, the E‐form underwent ROMP by a second generation Grubbs catalyst. In contrast, Z‐form did not undergo polymerization under similar conditions. The MALDI‐TOF spectrum of E‐form after polymerization showed the presence of oligomers of >5.2 kDa.
COVID‐19 and the heart: An update for clinicians
Authors: Goha Ahmed , Mezue Kenechukwu , Edwards Paul , Nunura Felix , Baugh Dainia , Madu Ernest 
Published: June 2020

AbstractSARS‐CoV‐2, the cause of the COVID‐19 pandemic has significantly impacted cardiovascular healthcare. Patients with pre‐existing cardiovascular disease are at higher risk of morbidity and mortality. The virus may affect the heart directly and indirectly with clinical syndromes of acute myocardial injury, myocarditis, acute coronary syndromes, heart failure, arrhythmias, and venous thromboembolism. Some therapeutics under investigation for COVID‐19 may also have adverse cardiac effects. The involvement of the RAAS system in viral entry makes it pertinent to consider the effects of medications that modulate the system. Comprehensive knowledge of peculiar cardiovascular manifestations of COVID‐19 and the role of RAAS in the prognosis of COVID‐19 disease is needed for optimal patient management.
Privacy‐preserving cooperative localization in vehicular edge computing infrastructure
Authors: Chandra Shit Rathin , Sharma Suraj , Watters Paul , Yelamarthi Kumar , Pradhan Biswajeet , Davison Richard , Morgan Graham , Puthal Deepak 
Published: June 2020

SummaryAdvancement of computing and communication techniques transforms the traditional transport system into the intelligent transportation system (ITS). The development of distributed computing in a vehicular network platform also called Vehicular Edge Computing (VEC) promise to address most of the challenges faced by the ITS. Localization is important in these vehicular networks because of its key contribution in autonomous driving, smart traffic monitoring, and collision avoidance services. For localization, current GPS and hybrid methods are in‐efficient because of GPS outage in urban infrastructure and dynamic nature of the vehicular networks. The cooperative localization approaches, on the other hand, use dedicated short range communication to broadcast messages and estimate location. However, these messages are un‐encrypted and periodic which gives a privacy risk for vehicles. This article presents a privacy‐preserving cooperative localization in vehicular network based upon dynamic pseudonym changing strategy. First, the localization delay is addressed with the implementation of dynamic vehicular edge assignment for computational task management. In the next step, the localization is estimated from the neighbor and road side unit ranging measurement followed by a real‐time prediction of the vehicle. The performance of the proposed algorithms is analyzed in terms of localization accuracy and privacy preservation strength. Furthermore, the proposed method is simulated in a real city scenario followed by localization accuracy and privacy analysis. Finally, the localization accuracy and privacy strength of the proposed approach are compared with the state‐of‐the‐art methods.
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells
Authors: Pearson Frances E , Tullett Kirsteen M , Leal‐Rojas Ingrid M , Haigh Oscar L , Masterman Kelly‐Anne , Walpole Carina , Bridgeman John S , McLaren James E , Ladell Kristin , Miners Kelly , Llewellyn‐Lacey Sian , Price David A , Tunger Antje , Schmitz Marc , Miles John J , Lahoud Mireille H , Radford Kristen J 
Published: June 2020

AbstractObjectivesVaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C‐type lectin‐like receptor CLEC9A is expressed exclusively by CD141+ DCs and regulates CD8+ T‐cell responses. We developed a new vaccine comprising a human anti‐CLEC9A antibody fused to WT1 and investigated its capacity to target human CD141+ DCs and activate naïve and memory WT1‐specific CD8+ T cells.MethodsWT1 was genetically fused to antibodies specific for human CLEC9A, DEC‐205 or β‐galactosidase (untargeted control). Activation of WT1‐specific CD8+ T‐cell lines following cross‐presentation by CD141+ DCs was quantified by IFNγ ELISPOT. Humanised mice reconstituted with human immune cell subsets, including a repertoire of naïve WT1‐specific CD8+ T cells, were used to investigate naïve WT1‐specific CD8+ T‐cell priming.ResultsThe CLEC9A‐WT1 vaccine promoted cross‐presentation of WT1 epitopes to CD8+ T cells and mediated priming of naïve CD8+ T cells more effectively than the DEC‐205‐WT1 and untargeted control‐WT1 vaccines.ConclusionsDelivery of WT1 to CD141+ DCs via CLEC9A stimulates CD8+ T cells more potently than either untargeted delivery or widespread delivery to all Ag‐presenting cells via DEC‐205, suggesting that cross‐presentation by CD141+ DCs is sufficient for effective CD8+ T‐cell priming in humans. The CLEC9A‐WT1 vaccine is a promising candidate immunotherapy for malignancies that express WT1.
Family‐based treatment via videoconference: Clinical recommendations for treatment providers during COVID‐19 and beyond
Authors: Matheson Brittany E. , Bohon Cara , Lock James 
Published: June 2020

AbstractThe necessity to employ distance‐based methods to deliver on‐going eating disorder care due to the novel coronavirus (COVID‐19) pandemic represents a dramatic and urgent shift in treatment delivery. Yet, TeleHealth treatments for eating disorders in youth have not been adequately researched or rigorously tested. Based on clinical experience within our clinic and research programs, we aim to highlight the common challenges clinicians may encounter in providing family‐based treatment (FBT) via TeleHealth for children and adolescents with anorexia nervosa and bulimia nervosa. We also discuss possible solutions and offer practical considerations for providers delivering FBT in this format. Additional research in TeleHealth treatment for eating disorders in youth may lead to improved access, efficiency, and effectiveness of FBT delivered via videoconferencing.
The role of B cells in heart failure and implications for future immunomodulatory treatment strategies
Authors: García‐Rivas Gerardo , Castillo Elena Cristina , Gonzalez‐Gil Adrian M. , Maravillas‐Montero José Luis , Brunck Marion , Torres‐Quintanilla Alejandro , Elizondo‐Montemayor Leticia , Torre‐Amione Guillermo 
Published: June 2020

AbstractDespite numerous demonstrations that the immune system is activated in heart failure, negatively affecting patients' outcomes, no definitive treatment strategy exists directed to modulate the immune system. In this review, we present the evidence that B cells contribute to the development of hypertrophy, inflammation, and maladaptive tissue remodelling. B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells. As B cells appear as active players in heart failure, we propose here novel immunomodulatory therapeutic strategies that target B cells and their products.
The response‐time relationship and covariate effects of acupuncture for chronic pain: A systematic review and model‐based longitudinal meta‐analysis
Authors: Li Caixia , Pei Qi , Chen Yaolong , Luo Xufei , Yang Nan , Li Thomas T. , Ding Junjie , Wang Yingwei 
Published: June 2020

AbstractBackground and ObjectiveCritical clinical questions regarding how soon and how long the analgesic effect will be achieved by acupuncture, as well as who will be responsive to acupuncture, need further address. The aim of the study was to investigate the response‐time relationship and covariate effects of acupuncture.Databases and Data TreatmentPubMed and EMBASE were searched up to December 2018 for randomized controlled trials that involved sham acupuncture, true acupuncture and conventional therapy. We used a model‐based longitudinal meta‐analysis to characterize the response‐time profile of these treatments.ResultsSeventy‐seven randomized clinical trials involved chronic shoulder, neck, knee and low back pain were included. The response‐time analysis suggested that the treatment duration of acupuncture will be 5 weeks or more to achieve 80% of maximum analgesic effect. Moreover a lower baseline pain intensity and the location of low back pain resulted in a lower pain relief of acupuncture intervention. The absolute maximum analgesic effects of sham acupuncture and conventional therapy were 22.6 and 15.8 points at a 0–100 NRS scale. The absolute effect of true acupuncture was 26.1 points for low back pain (relative effect of 3.5 and 9.4 points to sham and conventional therapy), 34.9 points for other pain body locations (relative effect of 12.3 and 19.1 points to sham and conventional therapy), in patients with a baseline pain intensity of 60 points.ConclusionThe treatment duration of acupuncture will not be less than 5 weeks to achieve 80% maximum analgesic effect. Higher analgesic effect was related to higher baseline pain intensity and pain location of neck, shoulder and knee.SignificanceOur systematic review and meta‐analysis provides the clear evidence for the treatment duration and significant related covariates of acupuncture intervention for chronic pain. These results provide useful suggestion for acupuncture intervention in clinical pain management.
Sifting the wheat from the chaff? Evidence for the existence of an asymmetric fibromyalgia phenotype
Authors: H. Kaziyama Helena , Barbour Julio , Galhardoni Ricardo , Aparecida da Silva Valquíria , R. D. Tesseroli de Siqueira Silvia , Listik Clarice , dos Santos Gabriel José , Yeng Lin T. , Marcolin Marco Antonio , Raicher Irina , Teixeira Manoel J. , Ciampi de Andrade Daniel 
Published: June 2020

AbstractBackgroundThe different phenotypic presentations of fibromyalgia (FM) have been infrequently studied and may have diagnostic and therapeutic implications. The aim of this study was to explore differences between FM patients with classical symmetric (s‐FM) presentation and FM patients with marked asymmetric (a‐FM) pain.MethodsWe performed two consecutive cross‐sectional studies on FM patients and matched healthy volunteers (HV). FM patients were divided into a‐FM (and s‐FM groups according to their score of pain intensity on each body side; patients with a difference of ≥40 mm in VAS between left and right sides were classified as a‐FM, otherwise classified as s‐FM. Participants (FM = 32; HV = 31) were assessed for clinical, cortical excitability (CE), quantitative sensory testing (QST; study 1), and intraepidermal nerve fibre density (IENFD) determinations (study 2).ResultsWhile pain intensity did not significantly differ between s‐FM and a‐FM patients, pain interference in daily activities was significantly higher in the a‐FM as compared to the s‐FM group (54.7 ± 8.9 and 37.6 ± 13.5; p < .0001). PPT was significantly lower in the more painful side of a‐FM as compared to the HV (27.7 ± 7.9 and 49.9 ± 13.0; p < .0001), while PPT in the less painful side of a‐FM was significantly higher than PPT values in the s‐FM (35.8 ± 8.3 and 27.7 ± 5.5; p = .031). S‐FM and a‐FM had significantly abnormal intracortical inhibition values on CE measurements compared to HV. There were no significant differences in IENFD between groups.ConclusionsWithin the current FM criteria, there exist different phenotypes with clinical, psychophysics, and neurophysiological findings that are not related to peripheral IENFD abnormalities.SignificanceCurrent fibromyalgia criteria may contain different phenotypes of fibromyalgia based on the lateralization of pain.
Debris cover on thaw slumps and its insulative role in a warming climate
Authors: Zwieback S. , Boike J. , Marsh P. , Berg A. 
Published: June 2020

AbstractThaw slumps in ice‐rich permafrost can retreat tens of metres per summer, driven by the melt of subaerially exposed ground ice. However, some slumps retain an ice‐veneering debris cover as they retreat. A quantitative understanding of the thermal regime and geomorphic evolution of debris‐covered slumps in a warming climate is largely lacking. To characterize the thermal regime, we instrumented four debris‐covered slumps in the Canadian Low Arctic and developed a numerical conduction‐based model. The observed surface temperatures >20° C and steep thermal gradients indicate that debris insulates the ice by shifting the energy balance towards radiative and turbulent losses. After the model was calibrated and validated with field observations, it predicted sub‐debris ice melt to decrease four‐fold from 1.9 to 0.5 mas the thickness of the fine‐grained debris quadruples from 0.1 to 0.4 m. With warming temperatures, melt is predicted to increase most rapidly, in relative terms, for thick (∼0.5–1.0 m) debris covers. The morphology and evolution of the debris‐covered slumps were characterized using field and remote sensing observations, which revealed differences in association with morphology and debris composition. Two low‐angle slumps retreated continually despite their persistent fine‐grained debris covers. The observed elevation losses decreased from ∼1.0 m/yr where debris thickness ∼0.2 mto 0.1 m/yr where thickness ∼1.0 m. Conversely, a steep slump with a coarse‐grained debris veneer underwent short‐lived bursts of retreat, hinting at a complex interplay of positive and negative feedback processes. The insulative protection and behaviour of debris vary significantly with factors such as thickness, grain size and climate: debris thus exerts a fundamental, spatially variable influence on slump trajectories in a warming climate. © 2020 John Wiley & Sons, Ltd.
Antioxidant and anti‐inflammatory peptide fraction from oyster soft tissue by enzymatic hydrolysis
Authors: Qian Bingjun , Zhao Xin , Yang Ye , Tian Chongchong 
Published: June 2020

AbstractRecent studies have confirmed that the peptide fractions derived from marine organisms exhibit good antioxidant and anti‐inflammatory activity, and oyster is an excellent nutrient resource with high‐protein content. In this study, the peptide fractions from oyster soft tissue were prepared after hydrolysis by pepsin (pH 2, 37°C), trypsin (pH 8, 37°C), and Maxipro PSP (pH 4.2, 50°C) with the optimized parameters (enzyme‐to‐substrate (E/S) ratio, 1:100 (w/w); hydrolysis time, 4 hr), respectively. Four fractions named as PEP‐1, PEP‐2, TRYP‐2, and MIX‐2 were obtained after separation with elution consisting of 20% or 40% ethanol. The MIX‐2 exhibited the highest hydrophobicity correlated well with its hydrophobic amino acid content, and TRYP‐2 exhibited much better antioxidant activity than other three elution samples. Furthermore, all of the bioactive peptide fractions were noncytotoxic and could selectively repress pro‐inflammatory mediators, TNF‐α, IL‐1β, IL‐6, and i‐NOS, at transcription level in RAW264.7 macrophage cells after LPS stimulation. The result suggests that the peptide fraction TRYP‐2 from oyster soft tissue hydrolysates might be a potential resource for natural anti‐inflammatory components.
A new endoscopic surgical approach to the larynx, hypopharynx, and neck lymphatics: The robotic‐assisted extended “Sistrunk” approach (RESA)
Authors: Simon Christian , Holsinger Floyd Christopher , Rheinwald Markus , Kemper Justin , Lambercy Karma 
Published: June 2020

AbstractBackgroundWe report on the feasibility of a novel robotic‐assisted extended “Sistrunk” approach (RESA) to the larynx, hypopharynx, and lateral neck lymphatics.MethodsStudies were performed using the da Vinci Xi and SP system on three cadavers comprising of three supraglottic laryngectomies, one partial hypopharyngectomy, and four lateral level II to IV neck dissections.ResultsIn all resections at first a central common working space overlying the hyoid bone was created. The da Vinci Xi system was used with two vestibular and two submental ports for laryngeal/hypopharyngeal resections, and an additional port through a facelift incision for level II to IV neck dissections. The da Vinci SP system was used with only one submental port.ConclusionsWe describe herein a novel endoscopic robotic approach to the larynx, hypopharynx, and neck based on the traditional “Sistrunk” procedure. The technique should help improving exposure of the primary lesion and reduce access‐related morbidity to the neck.
Salivary detection of SARS‐CoV‐2 (COVID‐19) and implications for oral health‐care providers
Authors: Bajaj Nimit , Granwehr Bruno P. , Hanna Ehab Y. , Chambers Mark S. 
Published: June 2020

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic has become a major public health crisis. The diagnostic and containment efforts for the disease have presented significant challenges for the global health‐care community. In this brief report, we provide perspective on the potential use of salivary specimens for detection and serial monitoring of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), based on current literature. Oral health‐care providers are at an elevated risk of exposure to COVID‐19 due to their proximity to nasopharynx of patients, and the practice involving the use of aerosol‐generating equipment. Here, we summarize the general guidelines for oral health‐care specialists for prevention of nosocomial transmission of COVID‐19, and provide specific recommendations for clinical care management.