bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiological effects of thiamethoxam on Zea mays and its electrochemical detection using a silver electrode
Authors: Ajermoun Nourddine , Lahrich Sara , Bouarab Lahcen , Bakasse Mina , Saqrane Sana , El Mhammedi Moulay Abderrahim 
Published: December 2019

AbstractBACKGROUNDThe aim of this work is the detection and quantification of bioaccumulated thiamethoxam (THM) in Zea mays at a silver electrode using square‐wave voltammetry. Thiamethoxam bioaccumulation and plant development were followed for 10 days from germination to seedling growth. Germination rate, accumulation rate, root length, and plant length were used as indicators. All experiments were carried out using several concentrations of THM (5.0 × 10−4, 1.0 × 10−3, 5.0 × 10−3, 3.4 × 10−2 and 5.0 × 10−2 mol L−1).RESULTSThe results confirm that Zea mays was sensitive to this insecticide and that germination and growth inhibition were dose dependent. The efficiency and utility of the proposed method were discussed. The current intensity increases linearly with an increase in the THM bioaccumulated in Zea mays. After 10 days,the recovery results of the extraction of THM from zea Mayes samples spiked with different concentrations were encouraging. The detection and quantification limits were found to be 9.58 × 10−6 mol L−1 (3*SD/B) and 3.13 × 10−5 mol L−1 (10*SD/B). The precision was 2.67% for eight repetitions in a solution of 3.5 × 10−4 mol L−1 THM. Histological tests were also performed to confirm the effect of THM on the plant and showed that exposure to THM induced a net histological modification in the primary root tissue of Zea mays.CONCLUSIONThe use of THM can affect the quality of the plant crop yield, and its accumulation in edible plants could pose a potential risk for human and animal health if the insecticide intake were to exceed the recommended tolerable limits. © 2019 Society of Chemical Industry
Use of elicitation in the cultivation of Bimi® for food and ingredients
Authors: Garcia‐Ibañez Paula , Moreno Diego A , Nuñez‐Gomez Vanessa , Agudelo Agatha , Carvajal Micaela 
Published: December 2019

AbstractBACKGROUNDCruciferous foods rich in health‐promoting metabolites are of particular interest to consumers as well as being a good source of bioactives‐enriched ingredients. Several elicitors have been used to stimulate the biosynthesis and accumulation of secondary metabolites in foods; however, little is known about the response of new hybrid varieties, such as Bimi®, under field‐crop production conditions. Therefore, this study was designed to evaluate the effect of salicylic acid (200 μmol L−1, SA), methyl jasmonate (100 μmol L−1, MeJA), and their combination on Bimi plant organs (inflorescences and aerial vegetative tissues – stems and leaves). For this, the composition of the glucosinolates present in the tissues was evaluated. Also, aqueous extracts of the plant material, obtained with different times of extraction with boiling water, were studied.RESULTSThe results indicate that the combined treatment (SA + MeJA) significantly increased the content of glucosinolates in the inflorescences and that MeJA was the most effective elicitor in leaves. Regarding the aqueous extracts, the greatest amount of glucosinolates was extracted at 30 min – except for the leaves elicited with MeJA, for which 15 min was optimal.CONCLUSIONThe elicitation in the field enriched leaves in glucobrassicin (GB), 4‐methoxyglucobrassicin (MGB), and neoglucobrassicin (NGB) and stems and inflorescences in glucoraphanin, 4‐hydroxyglucobrassicin, GB, MGB, and NGB. In this way, this enhanced vegetable material favored the presence of bioactives in the extracts, which is of great interest regarding enriched foods and ingredients with added value obtained from them. © 2019 Society of Chemical Industry
Adsorption and biotransformation of anthocyanin glucosides and quercetin glycosides by Oenococcus oeni and Lactobacillus plantarum in model wine solution
Authors: Devi Apramita , Konerira Aiyappaa Anu‐Appaiah , Waterhouse Andrew L 
Published: December 2019

AbstractBACKGROUNDAnthocyanins and flavonols play a significant role in contributing to wine color and mouthfeel, and the interaction of malolactic fermentation with these compounds is not well known. Here we investigated the adsorption of these compounds by Oenococcus oeni and Lactobacillus plantarum.RESULTSDelphinidin‐3‐glucoside (D3G) was adsorbed the most, followed by malvidin‐3‐glucoside (M3G) and peonidin‐3‐glucoside (P3G) for both the bacterial species, while flavonols were not adsorbed. An increase in β‐glycosidase activity suggested that this enzyme breaks down the anthocyanin glucosides, providing sugars for growth. An average decline of approximately 65% in enzyme activity in the presence of substantial residual sugar was observed. The specific metabolic rates were found to be dependent on the class of anthocyanin and species / strain of the bacteria. Selective adsorption of anthocyanins and not the flavonol glycosides suggest that electrostatic interactions mediate the adsorption. Further, a breakdown of anthocyanins resulted in phloroglucinol aldehyde from the flavonoid A‐ring and corresponding phenolic acids from the B‐ring, i.e., gallic acid for D3G, syringic acid for M3G, and vanillic acid for P3G.CONCLUSIONSThe breakdown and adsorption of the anthocyanin glucosides can help explain the color loss and aroma changes, such as the appearance of syringic and vanillic acid, associated with malolactic fermentation. © 2019 Society of Chemical Industry
Simulation‐Based Structured Education Supports Focused Neonatal Cranial Ultrasound Training
Authors: Mohammad Khorshid , Murthy Prashanth , Aguinaga Fernando , Fajardo Carlos , Eguiguren Luis , Castro Yessi , Guzman Veronica , Scott James N. , Chan Sonny , Soraisham Amuchou , Stritzke Amelie , Al Awad Essa , Kamaluddeen Majeeda , Thomas Sumesh ,   the Sonographic Clinical Assessment of the Newborn Group
Published: December 2019

ObjectivesBrain injury in preterm neonates may cause clinical deterioration and requires timeous bedside diagnosis. Teaching cranial ultrasound (US) skills using fragile preterm neonates is challenging. The purpose of this study was to test the effectiveness and feasibility of using task‐trainer computer‐based simulators and US‐suitable cranial phantoms in combination with teaching sessions in teaching novices to perform focused cranial US evaluations for identifying substantial intraventricular hemorrhage.MethodsThis was a prospective interventional educational study targeting participants with no prior skills in neonatal cranial US. Participants attended a 2‐day training workshop, with didactic and hands‐on interactive sessions using computer‐based and 3‐dimensional printed phantom simulators. Participants then performed a cranial US scan on a healthy neonate to assess the diagnostic quality of the images acquired. Individual precourse and postcourse knowledge tests were compared. To test recall, participants also submitted US images acquired on neonates within 3 and 6 months of attending the course.ResultsForty‐five participants completed the training modules. Mean knowledge scores increased significantly (in brain anatomy, brain physiology, intracranial disorders, and US physics domains). Thirty‐eight cranial US scans were acquired during the course, 22 within 3 months after completion, and 34 within 6 months after completion. Thirty‐two (84%) of the initial 38 case images, 17 (77%) of 22 images submitted within 3 months, and 32 (94%) of 34 images submitted within 6 months after course completion were of diagnostic quality.ConclusionsA structured training module with didactic and hand‐on training sessions using simulators and phantoms is feasible and supports training of clinicians to perform focused cranial US examinations.
The Utility and Feasibility of Extending Beyond Traditional Patient Descriptions in Daily Practice
Authors: Shin Jennifer J. , Carroll Thomas L. , Prince Anthony A. , Landman Adam B. 
Published: December 2019

Objectives/HypothesisInstitutional and national programs have endorsed the use of validated instruments in daily practice, but their utility for frontline clinicians is unknown. Our first objective was thus to determine if routinely obtained patient descriptions accurately predict disease‐specific validated instrument results. Our second objective was to assess the feasibility of deploying an electronic system to obtain and document patient‐reported descriptions of health status.Study DesignProspective assessment of consecutive eligible ambulatory care patients.MethodsFor the first objective, patients presenting with the same chief complaint at consecutive visits provided concurrent routine symptom descriptions and validated instrument responses. To determine whether patients’ routine descriptions predicted scores from disease‐specific instruments, receiver operator characteristic (ROC) curves, sensitivity/specificity, Spearman ρ correlation, and regression models were utilized. For the second objective, feasibility assessment focused on percent with successful response capture, time to questionnaire completion, and impact on physician time needed to obtain and document patient histories.ResultsFor the first objective, among patients with hearing loss, eustachian tube dysfunction, nasal obstruction, and chronic rhinosinusitis, the areas under the ROC curves were 0.38 to 0.83. Spearman ρ coefficients were 0.25 to 0.46. Sensitivity and specificity ranged from 15.9% to 87.8%, with correct classification in 42.3% to 55.2% of cases. For the second objective, there was a 91% completion rate. Completion times were 7:18 to 12:37 for new patients and 3:23 to 6:41 for established patients. Physician time savings were estimated at 11 minutes per patient.ConclusionsUsing validated instruments and electronic data collection systems in daily practice has practical and clinical implications. These topics warrant further study.Level of Evidence2c Laryngoscope, 130:S1–S13, 2020
Relationship of Overall Cardiovascular Health and Hearing Loss in The Jackson Heart Study Population
Authors: Curti Steven A. , DeGruy Joseph A. , Spankovich Christopher , Bishop Charles E. , Su Dan , Valle Karen , O'Brien Emily , Min Yuan‐I , Schweinfurth John M. 
Published: December 2019

ObjectivesTo evaluate the relationships among the overall cardiovascular health scoring tool, Life's Simple 7 (LS7), and hearing in an African‐American cardiovascular study cohort.MethodsUsing the Jackson Heart Study's cohort of African Americans, the relationships between the LS7 scoring metric and hearing of 1314 individuals were assessed. Standard audiometric data was collected and hearing loss was defined as a four‐frequency average of 500, 1000, 2000, and 4000 Hz greater than 25 dBHL (PTA4). Measures of reported tinnitus and dizziness were also collected. The LS7 scoring tool, which consists of seven individual categories (abstinence from smoking, body mass index, physical activity, healthy diet, total cholesterol <200 mg/dL, normotension, and absence of diabetes mellitus), was used as measure of overall cardiovascular health. Each category of the LS7 was broken down into poor, intermediate, and ideal subgroups as in accordance with the American Heart Association Strategic Planning Task Force and Statistics Committee. Unadjusted and adjusted gamma regression and logistic regression models were constructed for determining relationships between LS7 and hearing loss.ResultsHigher total LS7 scores (per 1‐unit increase) were associated with lower PTA4 in gamma regression analyses (RR = 0.942, 95% CI, 0.926–0.958, P < .001). This held true even after adjustments for age, sex, education, and history of noise exposure. Using logistic regression analyses to compare LS7 scores to presence of hearing loss, tinnitus, and vertigo; only hearing loss showed a statically significant relationship after adjustments for age, sex, education, and history of noise exposure.ConclusionsThis study shows a significant, graded association between higher life's simple seven scores and lower incidence of hearing loss.Level of Evidence2b. Laryngoscope, 2019
Gastroesophageal reflux in laryngopharyngeal reflux patients: Clinical features and therapeutic response
Authors: Lechien Jerome R. , Bobin Francois , Muls Vinciane , Eisendrath Pierre , Horoi Mihaela , Thill Marie‐Paule , Dequanter Didier , Durdurez Jean‐Pierre , Rodriguez Alexandra , Saussez Sven 
Published: December 2019

ObjectiveTo investigate the clinical features and the therapeutic response of laryngopharyngeal reflux (LPR) patients with or without gastroesophageal reflux disease (GERD).MethodsPatients with LPR symptoms were enrolled from three European Hospitals. The diagnosis of LPR and GERD was made through impedance‐pH monitoring (MII‐pH). A gastrointestinal endoscopy was realized in patients with digestive complaints or ≥60 years old. The 3‐ to 6‐month treatment was based on the association of diet, pantoprazole, alginate, and magaldrate regarding the MII‐pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used to evaluate the clinical evolution throughout treatment. The gastrointestinal endoscopy findings, clinical features, and therapeutic response were compared between patients with LPR and GERD (LPR/GERD) and patients with LPR.ResultsOne hundred and eleven LPR patients were included, 54 being LPR/GERD. LPR/GERD patients had a higher number of proximal reflux episodes compared with LPR patients. The prevalence of esophagitis, hernia hiatal, and lower esophageal sphincter insufficiency did not differ between groups. The presence of GERD was strongly associated with acid LPR. Patients without GERD had a higher proportion of nonacid and mixed LPR compared with LPR/GERD patients. The pre‐ to posttreatment evolutions of RSS and RSA were quite similar in both groups, with the exception of the 3‐ to 6‐month improvement of digestive symptoms, which was better in LPR/GERD group. The therapeutic success rates were 79.6% and 77.2% in GERD/LPR and LPR group, respectively.ConclusionGERD is predictive of acid LPR. The clinical evolution and the therapeutic response rates were quite similar in both groups.Level of Evidence4 Laryngoscope, 130: E479–E489, 2020
Biochar and manure addition influenced soil microbial community structure and enzymatic activities at eroded and depositional landscape positions
Authors: Sekaran Udayakumar , Sandhu Saroop S. , Qiu Yeyan , Kumar Sandeep , Gonzalez Hernandez Jose L. 
Published: December 2019

AbstractBiochar and manure application can modify soil microbial community structure and enhance biochemical activities. However, the studies about the influence of biochar and manure on the microbial communities on different geomorphological landforms (depositional and eroded landscapes) are scarce. In this study, we investigated the responses of soil biochemical activities and microbial communities to the addition of pinewood biochar, dairy manure (DM), and the dairy manure and pinewood biochar mixture (DMP) at a rate of 10 Mg ha−1, respectively, in comparison with control (CNT) at eroded and depositional landscape positions over 5 years. Data showed that the DMP treatment significantly increased cold‐water‐soluble organic carbon and hot‐water‐soluble organic carbon at the depositional landscape than CNT soils. Application of DMP increased total phospholipid fatty acid (PLFA) and bacterial PLFA by 31% and 20% compared with the CNT at the depositional landscape, respectively. At eroded landscape, total PLFAs and total bacterial PLFAs biomass concentrations were found 39% and 90% higher with DM than CNT soils. The addition of DM and DMP increased the activities of enzymes that are involved in the major nutrient cycling at depositional and eroded landscapes. At the phylum level, the proportion of Bacteroidetes was found lower in DMP, but the proportion of phylum Proteobacteria and Acidobacteria were increased. In conclusion, our study revealed that DMP influenced the labile nutrient pool, altered the microbial community structure, and increased bacterial composition and enzymatic activities at both the landscape positions.
MASS SPECTROMETRY IN VIROLOGICAL SCIENCES
Authors: Milewska Aleksandra , Ner‐Kluza Joanna , Dabrowska Agnieszka , Bodzon‐Kulakowska Anna , Pyrc Krzysztof , Suder Piotr 
Published: December 2019

Virology, as a branch of the life sciences, discovered mass spectrometry (MS) to be the pivotal tool around two decades ago. The technique unveiled the complex network of interactions between the living world of pro‐ and eukaryotes and viruses, which delivered “a piece of bad news wrapped in protein” as defined by Peter Medawar, Nobel Prize Laureate, in 1960. However, MS is constantly evolving, and novel approaches allow for a better understanding of interactions in this micro‐ and nanoworld. Currently, we can investigate the interplay between the virus and the cell by analyzing proteomes, interactomes, virus‐cell interactions, and search for the compounds that build viral structures. In addition, by using MS, it is possible to look at the cell from the broader perspective and determine the role of viral infection on the scale of the organism, for example, monitoring the crosstalk between infected tissues and the immune system. In such a way, MS became one of the major tools for the modern virology, allowing us to see the infection in the context of the whole cell or the organism. © 2019 John Wiley & Sons Ltd. Mass Spec Rev
A triple‐band dual‐polarized CRLH antenna for wireless applications
Authors: Ghosh Kalyanbrata , Das Sushrut 
Published: December 2019

AbstractThis paper presents an asymmetric coplanar waveguide fed triple‐band (1.99, 4.06, and 5.23 GHz) dual polarized antenna based on composite right‐ and left‐handed transmission line (CRLH‐TL) approach. The two lower bands of the antenna are linearly polarized whereas the rest is circularly polarized (CP). 20.49% 3 dB axial ratio bandwidth is achieved for the CP band which is higher than the recently reported triple band CRLH‐TL antennas. It has a compact size of 0.085 × 0.097 × 0.01λ0, where λ0 is the free space wavelength at ZOR frequency (1.99 GHz). The antenna is suitable for UMTS/WCDMA/PCS, WiMAX, and WLAN/Wi‐Fi applications.
Novel crest‐trough shaped spoof surface plasmon polaritons for low pass filtering applications
Authors: Anwar Rana Sadaf , Mao Lingfeng , Ning Huansheng 
Published: December 2019

AbstractIn this letter, a novel periodic crest‐trough (CT) shaped groove structure is proposed to excite and propagate spoof surface plasmon polaritons (SSPPs) at microwave frequency. Such a groove shape solves the problem of high transmission losses found in traditional microstrip transmission lines and presents tighter field confinement. Lower dispersion band is achieved by proposed CT‐SSPPs as compared to traditional structures, with 28% reduced asymptotic frequency than rectangular groove. Influence of some geometrical parameters is also explored. Further, planar low‐pass plasmonic filters with low reflection and high efficiency are investigated with compact transition circuitry for smooth and fast conversion between SSPPs and guided waves. To validate the proposed performance, two plasmonic filter structures are fabricated and measured. Full agreement is observed between the simulated and measured results for which reflection coefficient is lower than −10 dB in passband up to 3.07 and 2.52 GHz, respectively for both filters. The rejection level is higher than −15 dB in the whole stopband.
Inferior vena cava syndrome in neonates: An evidence‐based systematic review of the literature
Authors: Tieu Paul , Paes Bosco , Ahmed Afrah , Matino Davide , Chan Anthony , Bhatt Mihir 
Published: December 2019

AbstractNeonatal inferior vena cava syndrome (IVCS), though uncommon, is associated with significant morbidity and mortality. Information on risk factors, diagnosis, treatment, and outcomes is limited. This review comprised 61 neonates across 33 reports. Thrombosis occurred in 98% and 42% involved a central venous catheter. Diagnosis was mainly established by ultrasound in 82%. Therapeutically, heparin was employed in 36% and thrombolysis in 18% of the cases. The overall mortality was 23%. An algorithm of clinical signs, investigation, and management is presented. Well‐designed prospective studies are needed to establish a concrete investigational approach to neonatal IVCS and institute safe, evidence‐based treatment.
The effect of graft‐versus‐host disease on outcomes after allogeneic stem cell transplantation for refractory lymphoblastic lymphoma in children and young adults
Authors: Mitsui Tetsuo , Fujita Naoto , Koga Yuhki , Fukano Reiji , Osumi Tomoo , Hama Asahito , Koh Katsuyoshi , Kakuda Harumi , Inoue Masami , Fukuda Takahiro , Yabe Hiromasa , Takita Junko , Shimada Akira , Hashii Yoshiko , Sato Atsushi , Atsuta Yoshiko , Kanda Yoshinobu , Suzumiya Junji , Kobayashi Ryoji 
Published: December 2019

AbstractBackgroundPatients with relapsed or refractory lymphoblastic lymphoma (LBL) have a poor prognosis. The efficacy of allogeneic blood stem cell transplantation for treatment of this disease remains unclear in terms of transplantation‐related toxicity. Acute and chronic graft‐versus‐host diseases (GVHD) are both harmful to patients after allogeneic transplantation, but may have some positive effects through a substitute graft‐versus‐lymphoma effect.MethodsTo investigate the effect of GVHD on the survival of patients with refractory LBL, we retrospectively studied the outcomes of 213 patients with LBL who underwent first allogeneic stem cell transplantation before the age of 18 years, between 1990 and 2015 in Japan.ResultsThe five‐year overall survival (OS) and event‐free survival rates after stem cell transplantation were 50.3% (95% confidence interval [CI], 43.2‐56.9) and 47.8% (95% CI, 40.8‐54.4), respectively. In univariate landmark analyses, the probability of OS was significantly better in patients with aGVHD than in those without (P = 0.002, five‐year OS 58.1% vs 39.0%). The probability of OS was also better in patients with cGVHD than in those without (P = 0.036, five‐year OS 72.2% vs 54.7%). Multivariate analysis demonstrated that only aGVHD was associated with better OS (hazard ratio, 0.63; 95% CI, 0.42‐0.94, P = 0.024). Progression and recurrence statuses at SCT were associated with poor prognosis. The patients with grade II aGVHD showed the best prognosis (five‐year OS: 65.6%).ConclusionOur results suggest that the occurrence of aGVHD may be associated with better outcomes in patients with relapsed/refractory LBL who undergo allogeneic transplantation.
Pharmacokinetics and population pharmacokinetics in pediatric oncology
Authors: Sassen Sebastiaan D.T. , Zwaan C. Michel , van der Sluis Inge M. , Mathôt Ron A.A. 
Published: December 2019

AbstractPharmacokinetic research has become increasingly important in pediatric oncology as it can have direct clinical implications and is a crucial component in individualized medicine. Population pharmacokinetics has become a popular method especially in children, due to the potential for sparse sampling, flexible sampling times, computing of heterogeneous data, and identification of variability sources. However, population pharmacokinetic reports can be complex and difficult to interpret. The aim of this article is to provide a basic explanation of population pharmacokinetics, using clinical examples from the field of pediatric oncology, to facilitate the translation of pharmacokinetic research into the daily clinic.