bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating occupational stress of disaster and emergency medical management center 115 and the role of demographic variables
Authors: lebni Javad Yoosefi , Gheshlaghi Parvin Abdi , Toghroli Razie , Garosi Vahid Hatami , Abbas Jaffar , Kalhori Reza Pourmirza , Salahshoor Mohammad Reza , Kianipour Neda , Tharwani Munira , ziapour arash 
Published: June 2020

Abstract
Background: The first and one of the most important chains of providing care to patients is pre-hospital emergency medical services. Personnel employed in this sector are at risk of occupational stress due to the nature of their job which can affect their health and quality of services provided to patients. Therefore, the present study was conducted to investigate the occupational stress of the personnel of disaster and emergency medical management center 115 and the role of demographic variables in 2019.Methods: This is a descriptive-analytical study. 200 medical emergency personnel of Kermanshah province were selected through stratified sampling and according to inclusion criteria. A two-part questionnaire including demographic information and HSE standard questionnaire were used for collecting data. Finally, descriptive and inferential statistics (t-test and one-way ANOVA) were used for data analysis. Significance level was considered P<0.05. Results: The mean score of total occupational stress was 3.41±0.26. The highest and the lowest stress levels related to the role dimensions was calculated (4.34±0.35) and changes (2.72±0.86). There was a significant relationship between stress level with age, marital status, educational level, type of base of work place and hours of work per month, while there was no relationship between type of employment and work experience with stress level. Conclusion: Emergency medical personnel experience a high level of occupational stress. Senior managers can use the results of similar studies to think measures to reduce the experience of employees' stress.
Degenerative knee osteoarthritis animal model and changes in intraosseous pressure during pathological processes
Authors: Wang Shuo , Du Yu-ren , Ma Jian-xiong , Xue Yuan , Liu Wei , Huang Hong-chao , Zhang Lei , Ma Xin-long 
Published: June 2020

Abstract
Background Degenerative knee osteoarthritis (KOA) is a common clinical disease which affecting patients' quality of life. However, there is currently no standard animal model for KOA research. The purpose of this study was to find a reasonable age range of animal model for the studying of KOA pathological process, and to investigate Intraosseous pressure (IOP) in the process during different degeneration stages of KOA. Methods Male Dunkin-Hartley guinea pigs were selected and divided into groups of 3, 6, 9, 12, 18 months old by age, 10 in each group. All knees underwent imaging examination including X-ray, Micro CT and MRI. Observed the imaging findings with the use of Kellgren-Lawrence (K-L) classification and knee osteoarthritis MRI scores. Measured the IOP of distal femur and proximal tibia in each group, and observed the differences of bilateral tibiofemoral articular cartilage in histological and immunohistochemistry, staining results were evaluated by using Mankin’s score. Using one-way ANOVA and T-test were used to compare the differences indicators between groups. Results With the increase of age, changes in X-ray, Micro-CT and MRI imaging findings and pathological staining results of articular cartilage in all stages were consistent with the changing of degenerative KOA process. The IOP of distal femur and proximal tibia increased gradually with age, and reached its peak in 12-month age group, and then gradually decreased, there was a statistically significant difference of IOP between each group (femur side: F=8.261, P=0.000; tibial side: F=8.469, P=0.000). The IOP of the distal femur was slightly higher than that of proximal tibia, but the difference was not statistically significant (P>0.05). Conclusions Dunkin-Hartley guinea pig can be used as an animal model to study different pathological stages of KOA. And there might be a correlation between the changes of IOP and the pathological progress of articular cartilage and subchondral bone in distal femur and proximal tibia.
Involvement of Final year Medical Students in Hospital work during COVID-19 pandemic: A students’ perspective
Authors: Rawat Priya , Joshi Chitra , Joshi Anil Kumar , Sayana Ashutosh , Bisht Yamini , Joshi Shreya 
Published: June 2020

Abstract
Background: The Coronavirus disease (COVID-19) has upended medical education. This pandemic has risen uncertainty over the start of the normal routine of studies in medical universities. Amidst the worldwide shortage of doctors, there is widespread dilemma and disagreement regarding the role of the medical students during this pandemic. Medical education is suspended and the students are barred from being direct medical providers unless there is a critical need for the additional healthcare workforce. Considering these facts we have done a survey amongst medical students of pre-final and final year to know and evaluate their opinion and outlook regarding their involvement in the hospital work at the time of the ongoing COVID 19 pandemic. Materials and Method: This is a cross-sectional study among the clinic going medical students of Government Doon Medical College Dehradun, India. It is used to know their opinion regarding their voluntary initiative to actively participate and usefulness in the hospital works while going through their classes and hospital postings. We have circulated a questionnaire among 385 medical students to know their mindset and formulate a plan to include them in the future clinical hospital works in case the pandemic situation worsens.Statistical analysis is performed using SPSS version 25. Chi-square test was used to evaluate the association between the two variables. A two-tailed p < 0.05 was considered statistically significant. Results: Out of 294 respondents 62.2% had a high motivation to work in the hospital. This was synergized by the worldwide appreciation of doctors according to 88.8% of students. A sense of duty towards the patients was clear by the responses which surpassed the fear of the disease and the belief of being a better doctor (94.2%). Conclusion: The majority of medical students were highly motivated to be a part of the hospital workforce and help to fight this apocalyptic pandemic.
NEB mutation is associated with high mutational burden and worse colorectal-cancer survival
Authors: Xu Mingyue , Yuan Lijun , Wang Yan , Chen Shuo , Zhang Lin , Zhang Xipeng 
Published: June 2020

Abstract
Background: Nebulin (NEB) as a protein-coding gene have been well demonstrated its vital roles in skeletal muscles but no study for association between NEB mutation and cancer.Methods: Here, we systematically analyzed mutation spectrum of colorectal cancer (CRC) samples and associations between NEB somatic mutation and CRC patients' tumor mutation burden (TMB) and prognosis by using TCGA-COAD project mutation dataset.Results: Mutational signatures detected from CRC samples indicated pivotal roles of defective DNA damage repair process and polymerase activity in CRC initiation. NEB somatic mutation was found in about 16% CRC patients. Besides, NEB mutation was identified as an independent factor for high CRC TMB and inferior prognosis. Significantly mutated gene (SMG) analysis identified several genes including RNF43, SETD1B, MBD6 and so on, whose mutation states were profoundly influenced by NEB mutation and might be tumor driver genes in CRC initiation and progression.Conclusions: In conclusion, NEB might be a novel CRC-related genes that could affect patients' prognosis by perturbing genome instability.
Sunlight and vitamin D in the prevention of coronavirus disease (COVID-19) infection and mortality in the United States
Authors: Li Yajia , Li Qiangxiang , Zhang Ning , Liu Zhenhua 
Published: June 2020

Abstract
The coronavirus disease (COVID-19) is an infectious disease caused by the most recently discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aims to investigate associations between sunlight and vitamin D, using latitude as an indicator, with COVID-19 cases and related deaths in the United States. General regression and Chi-square test were used to examine the associations between latitude and COVID-19 cases and deaths. The analyses indicated that latitudes were marginally associated with cases (p = 0.0792) and deaths (p = 0.0599), with an increase of 2491 cases and 189 deaths of the total numbers in the mainland of US for every unit of increase of the latitude. When the states were classified into high latitude (>N 370) and low latitude (<N 370) groups, both the cases (702 vs 255 cases/100k population) and deaths (43 vs 11 deaths/100k population) were significantly different (p < 0.001) between the two categories. The results suggested that sunlight and vitamin D, with latitude as an indicator, might be associated with decreased risks for both COVID-19 cases and deaths. These findings warranted urgent needs of large cohort, clinical and pre-clinical studies to assess the impact of VD on the prevention of COVID-19.
Understanding the COVID19 infection curves -- finding the right numbers
Authors: Anghel Dragos-Victor , Anghel Ioan Tudor Alexandru 
Published: June 2020

Abstract
We analyze the evolution of the COVID19 pandemics and show that the basic compartmental SIR model cannot explain the data, some characteristic time series being by more than an order of magnitude different from the fit function over significant parts of the documented time interval. To correct this large discrepancy, we amend the SIR model by assuming that there is a relatively large population that was infected but was not tested and confirmed. This assumption qualitatively changes the fitting possibilities of the model and, despite its simplicity, in most cases, all the time series can be quite well reproduced. Nevertheless, in some cases (i.e., countries or regions) the estimated susceptible population decreases too fast. In such a case, the observed dynamic is only due to the transitions between the two infected compartments--the confirmed infected and the unconfirmed infected--and the rate of closing the cases (by recovery or death) in the confirmed infected compartment. Our analysis proves that the number of infected people is significantly larger than the one recorded and we provide a method to estimate it. We also discuss some relevant extensions of this model, to improve the interpretation and the fitting of the data.
A web survey to assess the perceived mental healthcare among Medical Imaging Professionals during COVID-19 pandemic
Authors: Kotian Rahul P , Faujdar Disha , D'souza Brayal , Kotian Sneha P , Kunaparaju Sindhura , David Leena R 
Published: June 2020

Abstract
Importance: Medical Imaging Professionals (MIP’s) providing imaging services exposed to coronavirus disease 2019 (COVID-19) could be psychologically stressed.Objective: To assess the magnitude of the perceived mental health outcomes among MIP’s providing imaging services to patients exposed to COVID-19. We examined the psychological stress, depression and anxiety, experienced by MIP’s in the midst of the outbreak. Background: During the first week of March,2020 the surge of coronavirus disease (COVID-19) cases reached all over the globe with more than 150,000 cases. Healthcare national and international authorities have already initiated awareness and lockdown activities. Design, Settings, and Participants: This cross-sectional, web survey-based study collected demographic data and mental health measurements from 250 MIP’s from April 29, 2020, to May 15, 2020. MIP’s working during the pandemic in hospitals for patients with COVID-19 were eligible. An online sample of MIPs was successfully recruited via the authors' networks in India using data collection tool – write google forms. A DASS21 online questionnaire was completed by the participants and then their mental health was assessed.Results: Of 400 invited MIP’s, 314 (78.5%) participated in the study; and 187 (59.5%)were included as per inclusion criteria. Hundred and three (55.08%) participants screened positive for depression, 105 (56.14%) for anxiety, and 80 (42.78%) for stress. However, 25 (13.36%), 18 (9.62%) and 16 (8.55%) screened positive for extremely severe for depression, anxiety and stress respectively.Conclusion and Relevance: In this web survey of MIP’s during COVID-19 pandemic, participants reported experiencing high rates of psychological depression, anxiety and stress, especially frontline MIP’s directly engaged in the imaging procedures for patients with COVID-19.
Engineering mesenchymal stem cells with neutralizing and anti- inflammation dual-capability against SARS-CoV-2 infection
Authors: Zhang Xiaoqing , Han Ping , Wang Haiyong , Xu Yanqin , Li Fanlin , Li Min , Fan Lilv , Zhang Huihui , Dai Qiang , Lin Hao , Qi Xinyue , Liang Jie , Wang Xin , Yang Xuanming 
Published: June 2020

Abstract
The emergence of the novel human coronavirus SARS-CoV-2 has caused a worldwide epidemic of coronavirus disease 2019 (COVID-19), which markedly affected the global health and economy. Both uncontrolled viral replication and proinflammatory cytokine storm can cause severe tissue damage in COVID-19 patients. SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as its entry receptor. In this study, we generated ACE2 extracellular domain-Fc and scFv-IL6R-Fc fusion protein to differentially neutralize virus and temper cytokine storm. The hACE21-740-Fc fusion protein showed potent inhibitory effect on pseudotyped SARS-CoV-2 entry and good safety profile in mice. The scFv-IL6R-Fc showed strong blockade effect on IL-6 signal activation. In addition, we established a mesenchymal stem cells (MSCs)-based hACE21-740-Fc and scFv-IL6R-Fc delivery strategy, which provided a potential rapid option for urgent clinic therapeutic need of COVID-19 patients.
Towards government mechanisms of sponge city construction in China: insights from developed countries
Authors: Yawen Wu , Jun Liu , Haowen Xie , Guangyuan Yu , Hong Zhou , Yichen Yan 
Published: June 2020

Abstract
The sponge city concept is a new strategy for China designed to solve its urban water problems. The tasks involved in sponge city construction (SCC) have brought new challenges regarding the urban construction process for local Chinese governments. However, there is still no comprehensive and systematic study of the government mechanisms for guiding the construction of sponge cities. This paper aims to develop an evaluation index system of government mechanisms at the whole-of-nation scale. This system covers five elements of government mechanisms. This evaluation index system covers the specific content of the government mechanism anticipated before the process of SCC. Since work systems, functions, and capacities differ with each given local government, the work mechanism of local governments can be adapted to local conditions according to the research results of this paper. By doing so it is possible to make full use of the constraint and management function of each indicator, so that all departments can constantly optimize the allocation of resources and clarify responsibilities, so as to effectively promote the construction of a sponge city.
Comparative Effectiveness of Adjustable Lordotic Expandable versus Static Lateral Lumbar Interbody Fusion Devices: One Year Clinical and Radiographic Outcomes
Authors: Li Yan Michael , Frisch Richard F. , Huang Zheng , Towner James , Li Yan Icy , Greeley Samantha , Ledonio Charles 
Published: June 2020

Aims:This study aims to understand the clinical and radiographic outcomes between patients treated with static and expandable interbody spacers with adjustable lordosis for minimally invasive (MIS) lateral lumbar interbody fusion (LLIF).Background:The use of large interbody spacers in MIS LLIF offers favorable clinical and radiographic results. Static interbody spacers may cause iatrogenic endplate damage and implant subsidence due to forceful impaction and excessive trialing. Expandable interbody spacers with adjustable lordosis offerin situexpansion that may optimize endplate contact and maximize and maintain sagittal alignment correction until fusion occurs.Objective:The objective of this study is to compare the clinical and radiographic outcomes between patients treated with static and expandable interbody spacers with adjustable lordosis for MIS LLIF.Methods:This is a multi-surgeon, retrospective, Institutional Review Board-exempt chart review of consecutive patients who underwent MIS LLIF at 1-2 contiguous level(s) using either a polyetheretherketone (PEEK) static (32 patients) or a titanium expandable spacer with adjustable lordosis (57 patients). The mean differences of radiographic and clinical functional outcomes were collected and compared from preoperative up to 12-month postoperative follow-up. Statistical results were significant if P<0.05.Results:The mean improvement of VAS back pain scores from preoperative to 6 and 12 months was significantly higher in the expandable group compared to the static group (P<0.05). Mean improvement of Oswestry Disability Index (ODI) scores from preoperative to 3, 6, and 12 months were significantly higher in the expandable group compared to the static group (P<0.001). The expandable group had a significantly greater mean improvement in segmental lordosis from preoperative to 6 weeks, 3, 6, and 12 months (P<0.001). For disc height, the mean improvement from preoperative to 6 weeks and 3 months was more significant in the expandable group compared to the static group (P<0.05). In the expandable group, the mean improvement from preoperative to 6 weeks, 3, and 6 months was significantly greater compared to the static group for neuroforaminal height (P<0.001). Subsidence was 0% in the expandable group and 32.4% (12/37) in the static group.Conclusion:This study showed significant positive clinical and radiographic outcomes for patients who underwent MIS LLIF using titanium expandable interbody spacers with adjustable lordosis based on significant changes in VAS back pain scores, ODI scores, and radiographic parameters at 12-month follow-up. There was a 0% subsidence rate in the expandable group, compared to a 32% subsidence rate in the static group.
Building Connections: Reducing Social Isolation for Mothers in Culturally and Linguistically Diverse Communities through a Sharing and Learning Group
Authors: Theobald Maryanne , Mc Fadden Amanda , Cox Mandy 
Published: June 2020

Background:
Social isolation is an everyday experience for many mothers and children within culturally and linguistically diverse communities. Engaging in group experiences with others provides authentic opportunities to make social connections, along with sharing common interests.

Aim:
This paper reports on a project that involved working within a transdisciplinary team at a community group in Brisbane, Australia. The Women and Children’s Learning and Sharing Community Group was a targeted program to foster mental health and feelings of well-being for mothers and children who were identified as at risk of social isolation.

Methods:
Semi-structured, audio-recorded interviews were conducted to gain the experiences of being involved in the community group from the perspectives of mothers and support workers. Summative Content Analysis is used to explore the transcribed accounts of the mothers and support workers who came together at the women’s sharing and learning group and, in particular, how the group facilitated growth-fostering connections to reduce the impact of social isolation.

Results:
Using a Relational-Cultural Theory and a Relational Agency Framework lens, thematic Content Analysis of the mothers’ accounts reveal three themes of 1) Freedom, 2) Connection, and 3) Transformation. Exploration of mothers and support workers’ accounts highlighted four interactional elements as foundational to the program: 1) Respecting Group Identity, 2) Building a relaxed, mother-focused, and child-inclusive atmosphere, 3) Respecting diversity and the mutual enhancement of competence and 4) Fostering positives and strengths of the members.

Conclusion:
Recommendations are provided when working with culturally and linguistically diverse communities include: 1) Provide concrete support; 2) Make use of participants’ strengths and partnerships, 3) Provide culturally sensitive and inclusive practice, 4) Build a sense of community, mutual support and connections. Proposed key learnings highlight the importance of transdisciplinary teams and strength-based approaches when working in culturally and linguistically diverse communities.
Analysis of Secretary Job Advertisement Content for Secretarial Skills Needs
Authors: Purwanto Purwanto , Rusdiyanto Wahyu , Respati Yudit Ayu 
Published: June 2020

Abstract: This paper aimed to identify and formulate the labor market demand on works skills for secretary indicated in job advertisements. The study conducted from February to July 2019. The particular research used content analysis with a qualitative approach. Data collection used documentation and focused on group discussion. The object of this research was job vacancy information for secretary in mass media and digital media. There were four stages of data analysis in this study. First, organizing and checking data. Second, rechecking data. Third, describing, summarizing, and organizing the coding containing categories that are more specific and distinguished from other categories. Fourth, conducting final analysis in making interpretation and drawing conclusions the research findings. The research discovered that the most needed of hard skill aspects for secretary are English language skill, Ms. Office and computer skill. Furthermore, the most needed of soft skill aspects are communication, attractive, and honest. Keywords: content analysis, worker skills, secretaryIdentifikasi Kebutuhan Keterampilan Sekretaris melalui Analisis Konten Lowongan PekerjaanAbstrak: Penelitian ini bertujuan mengidentifikasi dan merumuskan permintaan pasar tenaga kerja pada keterampilan kerja bagi calon sekretaris dalam iklan lowongan pekerjaan. Penelitian ini menggunakan analisis konten dengan pendekatan kualitatif. Pengumpulan data menggunakan dokumentasi dan focus grup discussion. Objek penelitian ini adalah informasi lowongan pekerjaan untuk calon sekretaris di media cetak dan digital. Analisis data penelitian ini menggunakan tahap-tahap sebagai berikut: 1) mengorganisasi data dan memeriksa data dengan cermat, 2) melakukan pemeriksaan ulang terhadap data, 3) mendeskripsikan, meringkas, dan mengorganisasi pengodean yang berisi kategori-kategori yang sudah lebih spesifik dan terbedakan dari kategori lain, 4) melakukan analisis terakhir, membuat interpretasi dan kesimpulan akhir berisi hasil temuan penelitian. Hasil penelitian menunjukkan bahwa (1) aspek hard skill yang banyak ditemukan untuk calon sekretaris adalah kemampuan bahasa inggris, kemampuan Ms. Office dan keterampilan komputer. (2) aspek soft skill yang banyak ditemukan untuk calon sekretaris adalah keterampilan komunikasi, berpenampilan menarik dan jujur. Kata kunci: Analisis Konten, Keterampilan Pekerja, Sekretaris