bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-functional benefits from targeted set-aside land in a Danish catchment
Authors: Hashemi Fatemeh , Kronvang Brian 
Published: September 2020

AbstractIn this study, we explored how a targeted land use change in a Danish catchment (River Odense) may provide multi-functional benefits through nitrogen (N)-load reductions to obtain good ecological quality in Odense estuary, protection of N-vulnerable groundwater aquifers, protection of Natura2000 sites and carbon sequestration. An N-load model linked to GIS thematic layers of known protected areas (Natura2000 sites and N-vulnerable groundwater aquifers) was utilised targeting high N-load areas to locate set-aside land. The achieved multi-functional benefits within the catchment and estuary were assessed and cost–benefit assessment was performed by dividing the total welfare costs of the set-aside by the total multi-functional benefits gained from each strategy. The results show that obtaining multi-functional benefits at the lowest cost requires a targeted shift of set-aside from the traditional hot-spot N-load areas to designated protected areas.
Effects of growth conditions and cultivability on the content of cyclitols in Medicago sativa
Authors: Ratiu I. A. , Al-Suod H. , Ligor M. , Monedeiro F. , Buszewski B. 
Published: September 2020

AbstractCyclitols are secondary metabolites with bioactive properties, naturally occurring in plants. Accumulation of such metabolites is directly connected with abiotic stressing factors. This article investigates the influence exercised by a series of abiotic factors including plant treatment with elicitors and cultivability in various regions of Europe, in some cases during two seasons, onto the amounts of cyclitols produced in alfalfa (Medicago sativa L.). The obtained results highlighted that NaCl elicitation acts to increase the quantity of cyclitols, while AgNO3 and Zn(NO3)2 generally decreased the obtained amount of cyclitols. When considering the seasonal impact, samples harvested in August presented a double amount of cyclitols in comparison with those collected in May. Correlation analysis proved that this phenomenon is related mainly to sunshine period versus low humidity. However, our investigation suggests that soil type, salinity level, lack of humidity, the number of sunny days, and plant elicitation play a role on the amount of cyclitols produced in alfalfa plant.
What is the “weight” of body mass index on sexual functioning in women? A mediation model
Authors: Di Nardo Maria , Conti Chiara , Di Francesco Giulia , Nicolardi Giulia , Guagnano Maria Teresa , Porcelli Piero 
Published: September 2020

AbstractPurposeIt is well known that body mass index (BMI) affects how individuals perceive their well-being and that obese individuals tend to report poorer levels of subjective health status. The aim of this study was to compare subjects with and without FSD and to examine the direct and indirect impact of BMI on female sexual dysfunction (FSD) in overweight/obese and normal-weight women.MethodsA cross-sectional study was conducted on 186 overweight/obese and 233 normal-weight women. FSD assessed with the Female Sexual Function Index (FSFI) was investigated in relation to body satisfaction assessed with the Body Uneasiness Test (BUT-A) and self-esteem assessed with the Rosenberg Self-Esteem scale (RSE).ResultsNo difference in the prevalence of FSD was found between overweight/obese (44.4%) and normal-weight women (55.6%), even though significant between-group differences in body image were found. Structural Equation Modelling (SEM) showed that BMI contribute to FSD only through the mediating role of body dissatisfaction and self-esteem.ConclusionsThe present results support the notion that sexual functioning is not related directly to BMI in women but to a more complex interactions of body weight, satisfaction with one’s own body image, and levels of self-esteem. Clinicians should take into account that for women having a good sexual life seems not related to body weight but to the way their body weight is perceived within the context of self-image.Level of evidenceLevel III, case–control analytic study.
The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network
Authors: Caratozzolo Salvatore , Zucchelli Alberto , Turla Marinella , Cotelli Maria Sofia , Fascendini Sara , Zanni Mara , Bianchetti Angelo , Psy Matteo Peli , Rozzini Renzo , Boffelli Stefano , Cappuccio Melania , Psy Federica Gottardi , Psy Chiara Vecchi , Bellandi Daniele , Caminati Claudia , Gentile Simona , Psy Elena Lucchi , Di Fazio Ignazio , Psy Marina Zanetti , Vezzadini Giuliana , Psy Chiara Forlani , Psy Maura Cosseddu , Psy Rosanna Turrone , Psy Silvia Pelizzari , Scalvini Andrea , Di Cesare Marco , Psy Marta Grigolo , Falanga Lina , Medici Nives , Palamini Nives , Psy Elisa Zanacchi , Psy Eleonora Grossi , Bellelli Giuseppe , Marengoni Alessandra , Trabucchi Marco , Padovani Alessandro ,   On behalf of COVIDEM Network
Published: September 2020

Abstract
Background
COVID-19 outbreak has led to severe health burden in the elderly. Age, morbidity and dementia have been associated with adverse outcome.

Aims
To evaluate the impact of COVID-19 on health status in home-dwelling patients.

Methods
848 home-dwelling outpatients with dementia contacted from April 27 to 30 and evaluated by a semi-structured interview to evaluate possible health complication due to COVID-19 from February 21 to April 30. Age, sex, education, clinical characteristics (including diagnosis of dementia) and flu vaccination history were obtained from previous medical records. Items regarding change in health status and outcome since the onset of the outbreak were collected. COVID-19 was diagnosed in patients who developed symptoms according to WHO criteria or tested positive at nasal/throat swab if hospitalized. Unplanned hospitalization, institutionalization and mortality were recorded.

Results
Patients were 79.7 years old (SD 7.1) and 63.1% were females. Ninety-five (11.2%) patients developed COVID-19-like symptoms. Non COVID-19 and COVID-19 patients differed for frequency of diabetes (18.5% vs. 37.9%, p < 0.001), COPD (7.3% vs. 18.9%, p < 0.001), and previous flu vaccination (56.7% vs. 37.9%, p < 0.001). Diabetes and COPD were positively associated with COVID-19, whereas higher dementia severity and flu vaccination showed an inverse association. Among COVID-19 patients, 42 (44.2%) were hospitalized while 32 (33.7%) died. Non COVID-19 patients’ hospitalization and mortality rate were 1.9% and 1.2%, respectively. COVID-19 and COPD were significantly associated with the rate of mortality.

Discussion/conclusions
A high proportion of adverse outcome related to COVID-19 was observed in home-dwelling elderly patients with dementia. Active monitoring though telehealth programs would be useful particularly for those at highest risk of developing COVID-19 and its adverse outcomes.
Multiscale frictional behaviors of sp2 nanocrystallited carbon films with different ion irradiation densities
Authors: Hu Zelong , Fan Xue , Chen Cheng 
Published: September 2020

Abstractsp2 nanocrystallited carbon films with large nanocrystallite sizes, smooth surfaces, and relative high hardness were prepared with different ion irradiation densities regulated with the substrate magnetic coil current in an electron cyclotron resonance plasma sputtering system. Their multiscale frictional behaviors were investigated with macro pin-on-disk tribo-tests and micro nanoscratch tests. The results revealed that, at an ion irradiation density of 16 mA/cm2, sp2 nanocrystallited carbon film exhibits the lowest friction coefficient and good wear resistant properties at both the macroscale and microscale. The film sliding against a Si3N4 ball under a contact pressure of 0.57 GPa exhibited a low friction coefficient of 0.09 and a long wear life at the macroscale. Furthermore, the film sliding against a diamond tip under a contact pressure of 4.9 GPa exhibited a stable low friction coefficient of 0.08 with a shallow scratch depth at the microscale. It is suggested that sp2 nanocrystallites affect the frictional behaviors in the cases described differently. At the macroscale, the contact interface via the small real contact area and the sp2 nanocrystallited transfer layer dominated the frictional behavior, while the sp2 nanocrystallited structure in the film with low shear strength and high plastic resistivity, as well as the smooth surface morphology, decided the steady low nanoscratch properties at the microscale. These findings expand multiscale tribological applications of sp2 nanocrystallited carbon films.
Practice patterns of kidney stone management across European and non-European centers: an in-depth investigation from the European Renal Stone Network (ERSN)
Authors: Ferraro Pietro Manuel , Unwin Robert , Bonny Olivier , Gambaro Giovanni 
Published: September 2020

Abstract
Rationale and objective
Kidney stones are a common condition in the general population, however, high-quality evidence for its management is scarce. We propose the creation of an international network with the aim of sharing practice patterns and patient data towards an improvement of our knowledge of the disease.

Study design
Cross-sectional survey.

Setting and participants
An online survey was circulated through several scientific societies. Items were grouped into six domains. Each center’s overall score (OS) was also calculated.

Analytical approach
Chi square and Mann–Whitney tests were performed for differences across centers.

Results
The countries that contributed most were Italy (8.6%), Turkey (6.6%), France and Spain (6.1%). Some type of nutritional work-up was implemented in 62% of centers. A DEXA scan was performed by 46% of centers, whereas some kind of acidification test was performed by 25% of centers. Most centers (80%) implemented blood investigations at least at baseline. With regard to 24-h urine exams, 7 out of 16 were performed by at least 50% of centers. Information on stone composition was collected by 58% of centers. The OS was significantly higher among higher-volume centers compared with lower-volume centers (p = 0.002). Significant differences between EU and non-EU centers were found.

Limitations
Cross-sectional design; no validation on information.

Conclusions
Our survey highlights the potential for the creation of a network of centers that could share information in a common database for observational research and for enrollment of patients in interventional trials.
Enacting Elementary Geometry: Participatory ‘Haptic’ Sense-Making
Authors: Price Sara , Yiannoutsou Nikoleta , Johnson Rose , Outhwaite Laura 
Published: September 2020

AbstractA central assumption within the embodied cognition paradigm is that particular action experiences are instrumental in providing children with sensorimotor contingencies that form the foundation for conceptualisation of and, later, communication of mathematical ideas. Digital technology designs that foster specific movements offer promising foundations for young children’s mathematical learning, together with haptic technologies that newly bring tactile sensorimotor experiences for children to draw on. This article reports on a qualitative study examining the role of a haptic learning environment supporting 7–8-year-old children’s embodied exploration of 3D shape. It examined the in situ dynamic unfolding of interaction of pairs of children, as they engaged with a haptic device. Multimodal analysis was focused on the process of how the prescribed enaction of the device-mediated interaction, the kinds of action experiences and action schemes it elicited and the strategies children collaboratively developed to complete tasks. Findings show how specific action experiences and, later, communication experiences, were shaped, not only by the prescribed enaction of the design, but also by embodied participatory sense-making, and demonstrate the potential for haptic technology in mediating new learning experiences for mathematics.
Teachers’ Involvement in Designing MERLO Items: Boundary Crossing
Authors: Robutti Ornella , Prodromou Theodosia , Aldon Gilles 
Published: September 2020

AbstractMeaning Equivalence Reusable Learning Objects (MERLO) items are a new kind of didactical tool that can be designed by teachers and used in classes, in tasks aimed at engaging students in deep reasoning, exploring and arguing about mathematical concepts. The interactions across communities of mathematics teachers and educators in on-line professional development were studied with attention to the phenomenon of boundary crossing of MERLO items, viewed as boundary objects in this article. The study analyseda first (international) crossing of the object that passedinstitutional boundaries (between Australian and Italian school systems), and a second crossing of the same object –inside the Australian institutional community – that passed boundaries (from static to dynamic representations) that we interpret in terms of method both for teachers and for researchers. This passage is possible due to the use of dynamic geometry software (GeoGebra) that supported a modification in the design of the item. The analysis shows boundary crossing as a process of transformation that can influence a modification (more or less stable) in the practices of the teachers involved and provides a deep research insight in relation to existing theoretical frameworks.
Consequences of Urban Living: Urbanization and Ground Beetles
Authors: Magura Tibor , Lövei Gábor L. 
Published: September 2020

Abstract
Purpose of Review
Urbanization is increasing worldwide, transforming environmental and habitat parameters, and causing adverse effects on organisms living in urban habitats. Urban studies on ground beetles are exponentially increasing and cover all levels of biological organization. Still, to date, there is no comprehensive paper reviewing the impacts of urbanization on ground beetles at different levels of biological organization.

Recent Findings
At the population level, urbanization induces changes in the morphological characters, including fluctuating asymmetry, physiological condition, behavioral characteristics, seasonal activity, population size, and genetic diversity in ground beetles. Different species groups (habitat specialists vs. generalists, large vs. small-sized species, poor vs. good dispersers, predators vs. herbivores) respond differently to urbanization. Community-level changes associated with urbanization include the abundance, taxonomic as well as functional diversity, community assembly mechanisms, composition, and body size distribution. At the ecosystem level, urbanization influences several ecosystem processes and functions related to ground beetles, but data are only available concerning the edge effect and predation.

Summary
Urbanization has a considerable effect at various levels of the biological organization on ground beetles living in urban habitats. However, results—especially at the population and community levels—show inconsistent patterns. This discrepancy may result from individual responses and different sensitivity of species to urbanization, suggesting the importance of individualistic and functional approach in future urban studies. To preserve a rich carabid diversity in urban areas, multi-scale greenspace planning and management schemes are needed; these will also ensure both the recreational and the diversity-preserving function of urban green spaces.
Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement
Authors: Hudak Justin , Hanley Adam W. , Marchand William R. , Nakamura Yoshio , Yabko Brandon , Garland Eric L. 
Published: September 2020

AbstractVeterans experience chronic pain at greater rates than the rest of society and are more likely to receive long-term opioid therapy (LTOT), which, at high doses, is theorized to induce maladaptive neuroplastic changes that attenuate self-regulatory capacity and exacerbate opioid dose escalation. Mindfulness meditation has been shown to modulate frontal midline theta (FMT) and alpha oscillations that are linked with marked alterations in self-referential processing. These adaptive neural oscillatory changes may promote reduced opioid use and remediate the neural dysfunction occasioned by LTOT. In this study, we used electroencephalography (EEG) to assess the effects of a mindfulness-based, cognitive training intervention for opioid misuse, Mindfulness-Oriented Recovery Enhancement (MORE), on alpha and theta power and FMT coherence during meditation. We then examined whether these neural effects were associated with reduced opioid dosing and changes in self-referential processing. Before and after 8 weeks of MORE or a supportive psychotherapy control, veterans receiving LTOT (N = 62) practiced mindfulness meditation while EEG was recorded. Participants treated with MORE demonstrated significantly increased alpha and theta power (with larger theta power effect sizes) as well as increased FMT coherence relative to those in the control condition—neural changes that were associated with altered self-referential processing. Crucially, MORE significantly reduced opioid dose over time, and this dose reduction was partially statistically mediated by changes in frontal theta power. Study results suggest that mindfulness meditation practice may produce endogenous theta stimulation in the prefrontal cortex, thereby enhancing inhibitory control over opioid dose escalation behaviors.
Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours
Authors: Romero-Garcia Rafa , Hook Roxanne W. , Tiego Jeggan , Bethlehem Richard A. I. , Goodyer Ian M. , Jones Peter B. , Dolan Ray , Grant Jon E. , Bullmore Edward T. , Yücel Murat , Chamberlain Samuel R. 
Published: September 2020

AbstractImpulsive and compulsive symptoms are common, tend to co-occur, and collectively account for a substantive global disease burden. Latent phenotyping offers a promising approach to elucidate common neural mechanisms conferring vulnerability to such symptoms in the general population. We utilised the Neuroscience in Psychiatry Network (NSPN), a cohort of young people (aged 18–29 years) in the United Kingdom, who provided questionnaire data and Magnetic Resonance Imaging scans. Partial Least Squares was used to identify brain regions in which intra-cortical myelination (measured using Magnetisation Transfer, MT) was significantly associated with a disinhibition phenotype, derived from bi-factor modelling of 33 impulsive and compulsive problem behaviours. The neuroimaging sample comprised 126 participants, mean 22.8 (2.7 SD) years old, being 61.1% female. Disinhibition scores were significantly and positively associated with higher MT in the bilateral frontal and parietal lobes. 1279 genes associated with disinhibition-related brain regions were identified, which were significantly enriched for functional biological interactions reflecting receptor signalling pathways. This study indicates common microstructural brain abnormalities contributing to a multitude of related, prevalent, problem behaviours characterised by disinhibition. Such a latent phenotyping approach provides insights into common neurobiological pathways, which may help to improve disease models and treatment approaches. Now that this latent phenotyping model has been validated in a general population sample, it can be extended into patient settings.
Transgenerational modification of dopaminergic dysfunctions induced by maternal immune activation
Authors: Weber-Stadlbauer Ulrike , Richetto Juliet , Zwamborn Ramona A. J. , Slieker Roderick C. , Meyer Urs 
Published: September 2020

AbstractPrenatal exposure to infectious and/or inflammatory insults is increasingly recognized to contribute to the etiology of psychiatric disorders with neurodevelopmental components. Recent research using animal models suggests that maternal immune activation (MIA) can induce transgenerational effects on brain and behavior, possibly through epigenetic mechanisms. Using a mouse model of MIA that is based on gestational treatment with the viral mimeticpoly(I:C) (= polyriboinosinic-polyribocytidilic acid), the present study explored whether the transgenerational effects of MIA are extendable to dopaminergic dysfunctions. We show that the direct descendants born to poly(I:C)-treated mothers display signs of hyperdopaminergia, as manifested by a potentiated sensitivity to the locomotor-stimulating effects of amphetamine (Amph) and increased expression of tyrosine hydroxylase (Th) in the adult ventral midbrain. In stark contrast, second- and third-generation offspring of MIA-exposed ancestors displayed blunted locomotor responses to Amph and reduced expression of Th. Furthermore, we found increased DNA methylation at the promoter region of the dopamine-specifying factor, nuclear receptor-related 1 protein (Nurr1), in the sperm of first-generation MIA offspring and in the ventral midbrain of second-generation offspring of MIA-exposed ancestors. The latter effect was further accompanied by reduced mRNA levels of Nurr1 in this brain region. Together, our results suggest that MIA has the potential to modify dopaminergic functions across multiple generations with opposite effects in the direct descendants and their progeny. The presence of altered DNA methylation in the sperm of MIA-exposed offspring highlights the possibility that epigenetic processes in the male germline play a role in the transgenerational effects of MIA.
Differential and unique patterns of synaptic miRNA expression in dorsolateral prefrontal cortex of depressed subjects
Authors: Yoshino Yuta , Roy Bhaskar , Dwivedi Yogesh 
Published: September 2020

AbstractAltered synaptic plasticity is often associated with major depressive disorder (MDD). Disease-associated changes in synaptic functions are tightly correlated with altered microRNA (miRNA) expression. Here, we examined the role of miRNAs and their functioning at the synapse in MDD by examining miRNA processing machinery at synapse and sequencing miRNAs and analyzing their functions in synaptic and total tissue fractions obtained from dorsolateral prefrontal cortex (dlPFC) of 15 MDD and 15 matched non-psychiatric control subjects. A total of 333 miRNAs were reliably detected in the total tissue fraction. Multiple testing following the Benjamini–Hochberg false discovery rate [FDR] showed that 18 miRNAs were significantly altered (1 downregulated 4 up and 13 downregulated;p < 0.05) in MDD subjects. Out of 351 miRNAs reliably expressed in the synaptic fraction, 24 were uniquely expressed at synapse. In addition, 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected;p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects. In vitro transfection studies and gene ontology revealed involvement of these altered miRNAs in synaptic plasticity, nervous system development, and neurogenesis. A shift in expression ratios (synaptic vs. total fraction) of miR-19b-3p, miR-376c-3p, miR-455-3p, and miR-337-3p were also noted in the MDD group. Moreover, an inverse relationship between the expression of precursor (pre-miR-19b-1, pre-miR-199a-1 and pre-miR-199a-2) and mature (miR-19b-3p, miR-199a-3p) miRNAs was found. Although not significantly, several miRNA processing enzymes (DROSHA [95%], DICER [17%], TARBP2 [38%]) showed increased expression patterns in MDD subjects. Our findings provide new insights into the understanding of the regulation of miRNAs at the synapse and their possible roles in MDD pathogenesis.