bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical study of attached macroalgae from the Madeira Archipelago and beach-cast macroalgae from the Canary Islands: multivariate analysis to determine bioresource potential
Authors: Nunes Nuno , Valente Sofia , Ferraz Sónia , Barreto Maria Carmo , Pinheiro de Carvalho Miguel A.A. 
Published: April 2020

AbstractFifteen attached macroalgae from the Madeira Archipelago, comprising three green, three red and nine brown algal species, as well as two beach-cast macroalgal samples, collected along the north shore of Gran Canaria, were assessed for their biochemical properties. The analysis included the determination of total minerals, total carbohydrates, protein, lipids, chlorophylla, total carotenoids, total phenolic content, fucoxanthin and phycobilins (allophycocyanin, phycocyanin and phycoerythrin). The results showed a high variability of biochemical composition, allowing for the targetting of specific bioresources for particular purposes, including functional foods. This work provides the foundation for a biorefinery strategy implementation plan, for which specific macroalgae may be targeted for valuable and beneficial compounds.
Transparency of digital native and embedded advertising: Opportunities and challenges for regulation and education
Authors: Reijmersdal Eva A. van , Rozendaal Esther 
Published: April 2020

Abstract
This article elaborates on one of the main characteristics of digital native and embedded advertising: its lack of transparency. Challenges and opportunities for disclosing native advertising practices as well as how educational measures concerning this type of advertising should look are discussed. In addition, a future research agenda is presented.
A linguistically-informed way of introducing Japanese verbs to second language learners
Authors: Hayashishita J.-R. , Tanaka Daiki , Ueyama Ayumi 
Published: April 2020

AbstractThis paper describes how the Japanese speakers’ knowledge is organized in regards to verbs, and proposes a linguistically-informed way of introducing it to second language learners. It is maintained by a number of researchers that each verb is stored with the information of its argument structure in the speaker’s mental lexicon. That is, a given verb is stored with the information of how many arguments it takes and what types of arguments they are. In this paper, capitalizing on this assumption, we will maintain that the knowledge of the native speakers of Japanese is organized in such a way that if a verb gives rise ton-number of different meanings, there aren-number of lexical entries, and each such entry is independently stored with the information concerning the meaning of the verb, the verb arguments and their accompanying particles. After the description of the organization of Japanese speakers’ knowledge in regards to verbs, as an effective way of introducing this to Japanese language learners, the paper proposes the format of an innovative approach to Japanese verbs reference book. This proposed format capitalizes onfull sentence definitionsin the sense of the CollinsCobuild Dictionary.
The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population
Authors: Li Jianmin , Wen Ming , Zhang Zhiping , Qiu Zhihua , Sun Yiming 
Published: April 2020

Abstract
Stroke is the major cause of death and disability worldwide. ABCA1 R219K has been suggested as a risk factor for ischemic stroke, but the results remain inconclusive in the Chinese population. This study aimed to assess the association between ABCA1 R219K and ischemic stroke using meta-analysis. A systematic literature search was conducted to select eligible studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Fourteen studies containing 2865 cases and 3227 controls were included in the meta-analysis and the results suggested that there is a strong association between ABCA1 R219K and the ischemic stroke risks (K vs. R: OR = 0.837, 95% CI: 0.735- 0.954, p=0.008; KK vs. RR: OR = 0.689, 95% CI: 0.520-0.912, p=0.009; KK+RK vs. RR: OR = 0.782, 95% CI: 0.691-0.885, p<0.001). Subgroup analysis revealed that significant association was found for the 4 genetic models (p<0.05) in the Southern population, while in the northern population significant association was only found under the dominant model (KK+RK vs. RR: OR = 0.744, 95% CI: 0.583- 0.949, p<0.017). This meta-analysis suggested that ABCA1 R219K polymorphism might be a protective factor against developing IS, indicating this SNP may contribute to the pathogenesis of ischemic stroke and might be potentially used as a biomarker to predict the susceptibility to ischemic stroke.
X-ray imaging and computed tomography for engineering applications
Authors: Zabler Simon , Maisl Michael , Hornberger Peter , Hiller Jochen , Fella Christian , Hanke Randolf 
Published: April 2020

Abstract
After an incremental development which took place over four decades, X-ray imaging has become an important tool for non-destructive testing and evaluation. Computed Tomography (CT) in particular beholds the power of determining the location of flaws and inclusions (e. g. in castings and composites) in three-dimensional object coordinates. Therefore, and thanks to a speed-up of the measurement, CT is now routinely considered for in-line inspection of electronics, castings and composites. When precision and not speed is important, Micro-CT (μCT) can be employed for Dimensional Measurements (DM, e. g. quality assurance and shape verification), as well as for in situ testing, and for characterizing micro-structures in metals and composites. Using appropriate image processing and analysis μCT can determine the local fibre orientation in composites, the granular morphology of battery cathodes or the inter-connectivity of certain phases in casting alloys.
Today, the large variety of X-ray instruments and methods poses an application problem which requires experience and a lot of knowledge for deciding which technique applies best to the task at hand. Application-specific guidelines exist for X-ray radiography testing (RT) only, whereas standardization has been applied to CT, unfortunately leaving out high resolution sub μ CT, and nano-CT. For the latter exist an equally high number of NDT applications, however these instruments still necessitate a profound expertise. The task is to identify key industrial applications and push CT from system standardization to application specific automation.
Work Statistics and Energy Transitions in Driven Quantum Systems
Authors: Engbers Michael , Heerwagen Mattes , Rosmej Sebastian , Engel Andreas 
Published: April 2020

Abstract
Thermodynamic quantities of small systems fluctuate and have to be characterised by their appropriate probability distributions. Within the two-point energy measurement prescription, the distribution of work in a quantum system can be derived from the transition probability from initial to final energy. We consider a simple yet representative model system starting in thermodynamic equilibrium and driven by an external force, and compare two different numerical techniques to determine this transition probability with respect to accuracy and numerical effort. In addition, we perform a semi-classical analysis of the process using the WKB approximation. The results agree well with the numerically exact values if Airy-tails modelling the tunnelling into classically forbidden regions of phase space are properly taken into account.
Adult height prediction by bone age determination in children with isolated growth hormone deficiency
Authors: Reinehr Thomas , Carlsson Martin , Chrysis Dionisios , Camacho-Hübner Cecilia 
Published: April 2020

Background
The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown.

Methods
The near adult height (NAH) of patients with IGHD in the KIGS database was compared retrospectively to adult height prediction calculated by the Bayley–Pinneau (BP) prediction based on bone age by Greulich–Pyle (GP) in 315 children and based on the Tanner-Whitehouse 2 (TW2) method in 121 children. Multiple linear regression analyses adjusted for age at GH start, age at puberty, mean dose and years of of GH treatment, and maximum GH peak in stimulation test were calculated.

Results
The mean underestimation of adult height based on the BP method was at baseline 4.1 ± 0.7 cm in girls and 6.1 ± 0.6 cm in boys, at 1 year of GH treatment 2.5 ± 0.5 cm in girls and 0.9 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 0.4 ± 0.6 cm in girls and 3.8 ± 0.5 cm in boys. The mean underestimation of adult height based on the TW2 method was at baseline 5.3 ± 2.0 cm in girls and 7.9 ± 0.8 cm in boys, at 1 year of GH treatment adult height was overestimated in girls 0.1 ± 0.6 cm in girls and underestimated 4.1 ± 0.4 cm in boys, while at last bone age determination adult height was overestimated in mean by 3.1 ± 1.5 cm in girls and 3.6 ± 0.8 cm in boys.

Conclusions
Height prediction by BP and TW2 at onset of GH treatment underestimates adult height in prepubertal IGHD children, while in mean 6 years after onset of GH treatment these prediction methods overestimated adult height.
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines
Authors: Mueller William F , Jakob Petra , Sun Han , Clauder-Münster Sandra , Ghidelli-Disse Sonja , Ordonez Diana , Boesche Markus , Bantscheff Marcus , Collier Paul , Haase Bettina , Benes Vladimir , Paulsen Malte , Sehr Peter , Lewis Joe , Drewes Gerard , Steinmetz Lars M 
Published: April 2020

Abstract
N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production. NGLY1 is a deglycosylating protein involved in the degradation of misfolded proteins retrotranslocated from the endoplasmic reticulum (ER). NGLY1-deficient cells have been reported to exhibit decreased deglycosylation activity and an increased sensitivity to proteasome inhibitors. We show that the loss of NGLY1 causes substantial changes in the RNA and protein landscape of K562 cells and results in downregulation of proteasomal subunits, consistent with its processing of the transcription factor NFE2L1. We employed the CMap database to predict compounds that can modulate NGLY1 activity. Utilizing our robust K562 screening system, we demonstrate that the compound NVP-BEZ235 (Dactosilib) promotes degradation of NGLY1-dependent substrates, concurrent with increased autophagic flux, suggesting that stimulating autophagy may assist in clearing aberrant substrates during NGLY1 deficiency.
A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination inSaccharomyces cerevisiae
Authors: Novarina Daniele , Desai Ridhdhi , Vaisica Jessica A , Ou Jiongwen , Bellaoui Mohammed , Brown Grant W , Chang Michael 
Published: April 2020

AbstractHomologous recombination is an important mechanism for genome integrity maintenance, and several homologous recombination genes are mutated in various cancers and cancer-prone syndromes. However, since in some cases homologous recombination can lead to mutagenic outcomes, this pathway must be tightly regulated, and mitotic hyper-recombination is a hallmark of genomic instability. We performed two screens in Saccharomyces cerevisiae for genes that, when deleted, cause hyper-recombination between direct repeats. One was performed with the classical patch and replica-plating method. The other was performed with a high-throughput replica-pinning technique that was designed to detect low-frequency events. This approach allowed us to validate the high-throughput replica-pinning methodology independently of the replicative aging context in which it was developed. Furthermore, by combining the two approaches, we were able to identify and validate 35 genes whose deletion causes elevated spontaneous direct-repeat recombination. Among these are mismatch repair genes, the Sgs1-Top3-Rmi1 complex, the RNase H2 complex, genes involved in the oxidative stress response, and a number of other DNA replication, repair and recombination genes. Since several of our hits are evolutionarily conserved, and repeated elements constitute a significant fraction of mammalian genomes, our work might be relevant for understanding genome integrity maintenance in humans.
Perykopa o nawróconym na krzyżu złoczyńcy (Łk 23, 40–43) w świetle Łukaszowej nauki o miłosierdziu
Authors: Hałas Stanisław 
Published: April 2020

Choć wszyscy czterej ewangeliści opowiadają o dwóch złoczyńcach ukrzyżowanych wraz z Jezusem, to jednak tylko Łukasz podaje rozmowę ukrzyżowanego Jezusa z jednym z nich. Obiecuje mu, że jeszcze tego samego dnia („dzisiaj”) znajdzie się z Nim w raju. W ten sposób nawrócony złoczyńca zostaje ukazany jako pierwszy człowiek, który otrzymuje zbawienie od umierającego Jezusa. W kontekście całej Ewangelii Łukaszowej jest on bardzo ważnym przykładem Bożego miłosierdzia, które uwidacznia się w zbawieniu.
How Processing Methodologies Can Distort and Bias Power Spectral Density Estimates of Seismic Background Noise
Authors: Anthony Robert E. , Ringler Adam T. , Wilson David C. , Bahavar Manochehr , Koper Keith D. 
Published: April 2020

AbstractPower spectral density (PSD) estimates are widely used in seismological studies to characterize background noise conditions, assess instrument performance, and study quasi-stationary signals that are difficult to observe in the time domain. However, these studies often utilize different processing techniques, each of which can inherently bias the resulting PSD estimates. The level of smoothing, the size of the data window, and the method used for actually estimating the spectral content can all have strong influences on PSD estimates and background noise statistics. We show that although smoothing reduces the variance of the PSD estimate, the corresponding decrease in frequency resolution can eliminate or distort features of interest. For instance, popular software packages such as Incorporated Research Institutions for Seismology Modular Utility for STAatistical kNowledge Gathering (MUSTANG) and earlier versions of Portable Array Seismic Studies of the Continental Lithosphere Quick Look eXtended (PQLX), which were designed for data quality control and are effective in that regard, are less suitable for scientific studies that require accurate resolution of spectral peaks, even for peaks as broad as the primary (∼14  s period) and secondary (∼7  s period) microseisms. We also demonstrate how the 1 and 3 hr data windows used in MUSTANG and PQLX can be strongly influenced by energy generated from moderate-size (M&gt;∼4.8) teleseismic earthquakes. The ubiquity of these events is likely skewing median ambient-noise estimates by as much as 5 dB upward, for periods of 10–50 s at high-quality broadband stations. Finally, we illustrate that many of the discrepancies between global low-noise models are attributable to processing methodologies rather than fundamental differences in the underlying seismic data.
Earthquake Early Warning ShakeAlert 2.0: Public Rollout
Authors: Kohler Monica D. , Smith Deborah E. , Andrews Jennifer , Chung Angela I. , Hartog Renate , Henson Ivan , Given Douglas D. , de Groot Robert , Guiwits Stephen 
Published: April 2020

AbstractThe ShakeAlert earthquake early warning system is designed to automatically identify and characterize the initiation and rupture evolution of large earthquakes, estimate the intensity of ground shaking that will result, and deliver alerts to people and systems that may experience shaking, prior to the occurrence of shaking at their location. It is configured to issue alerts to locations within the West Coast of the United States. In 2018, ShakeAlert 2.0 went live in a regional public test in the first phase of a general public rollout. The ShakeAlert system is now providing alerts to more than 60 institutional partners in the three states of the western United States where most of the nation’s earthquake risk is concentrated: California, Oregon, and Washington. The ShakeAlert 2.0 product for public alerting is a message containing a polygon enclosing a region predicted to experience modified Mercalli intensity (MMI) threshold levels that depend on the delivery method. Wireless Emergency Alerts are delivered for M 5+ earthquakes with expected shaking of MMI≥IV. For cell phone apps, the thresholds are M 4.5+ and MMI≥III. A polygon format alert is the easiest description for selective rebroadcasting mechanisms (e.g., cell towers) and is a requirement for some mass notification systems such as the Federal Emergency Management Agency’s Integrated Public Alert and Warning System. ShakeAlert 2.0 was tested using historic waveform data consisting of 60 M 3.5+ and 25 M 5.0+ earthquakes, in addition to other anomalous waveforms such as calibration signals. For the historic event test, the average M 5+ false alert and missed event rates for ShakeAlert 2.0 are 8% and 16%. The M 3.5+ false alert and missed event rates are 10% and 36.7%. Real-time performance metrics are also presented to assess how the system behaves in regions that are well-instrumented, sparsely instrumented, and for offshore earthquakes.
Challenges and Opportunities in Turning Large U.S. Archives of Analog Seismograms into a Modern Usable Resource
Authors: Richards Paul G. , Hellweg Margaret 
Published: April 2020

AbstractQuantitative seismology is based firmly on the analysis of actual ground motions, and the transition to digital recording in the 1980s enabled sophisticated new capabilities to extract useful results from waveforms. With some effort, these tools can also be applied to analog records. Focusing on assets available within U.S. institutions, we review the necessary steps and the challenges in enabling “data rescue”—that is, preserving the scientific information latent in large analog seismogram archives and making it usable. They include: determining what assets are available (the analog seismogram archives held by various institutions, with associated metadata on instrument responses, station locations, and timing information); developing a consensus on the top level of a triage process (which analog records most definitely should be rescued?); deciding the level of quality needed in copying original seismograms to media suitable for digitizing; assessing the relative merits of scanning and digitizing; and, the need for a community service in distributing scans and digital records, as they accumulate. The necessary level of effort can benefit from practical experience. For example, specific studies have used digitized versions of analog recordings to model earthquake sources and assess seismic hazard. Other studies have used them to gain experience with nuclear explosion signals recorded at regional distances, noting that regional signals enable explosions to be monitored down to levels much lower than those attainable teleseismically.The opportunities presented by large archives of analog seismograms include the insights they present to current and future seismologists studying earthquakes and explosions, into the practical areas of assessing seismic hazard, monitoring for test ban compliance down to low explosion yields—and prompt characterization of actual explosions should they occur, as well the traditional academic pursuit of a better understanding of earthquake physics.
Bacteriological profile and antibiotic sensitivity pattern in various body fluids –A retrospective study
Authors: Hawaldar Ranjana , Sodani Sadhna 
Published: April 2020

Several bacteria like E.Coli, Klebsiella, Acinetobacter, Pseudomonas etc cause infections in various body fluids. Infections of the body fluids are mostly a medical emergency and may be life threatening if not managed timely. Very limited data are available about the antibiotic susceptibility of bacteria causing infection of body fluids. This retrospective study was undertaken between January to October 2019 in the Microbiology department of our diagnostic centre with the aim of identifying the bacteria causing infection of various body fluids and also to study their antibiotic susceptibility pattern.This was a retrospective study carried out on 216 patients of all ages and both sexes registered for culture and sensitivity of different body fluids in the Microbiology department of our diagnostic centre between January to October 2019. The fluids included in the study were CSF, pleural, peritoneal, amniotic, ascitic, vitreous, synovial, aqueous, BAL fluid, bile fluid, semen, drain fluids from surgical sites, Endotracheal secretions and cystic fluids from breast, ovary and other sites.Male to female ratio was 2.17:1. The most common body fluid was cerebrospinal fluid (CSF) 31.02%, Klebsiella sps (22.9%) was the most frequently isolated bacteria, followed by Pseudomonas (21.3%), Acinetobacter (13.11%), Citrobacter (11.9%), E.Coli (8.19%), Stap. Aureus (8.19%), Enterococcus (4.91%), Stenotrophomonas (3.25), Candida sps (3.21%), Burkholderia and Proteus (1.63%) each. Gram positive bacteria were grown in 13.11% cases and 83.62% showed growth of Gram negative bacilli.Regular monitoring and surveillance of organisms causing infection of body fluids is required for formulating an antibiotic and infection control policy so as to guide the clinicians in choosing appropriate antibiotics before a culture report is available thus preventing the development of antimicrobial resistance.