bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinguishing the Roles of Antibiotic Stewardship and Reductions in Outpatient Visits in Generating a 5-Year Decline in Antibiotic Prescribing
Authors: Kissler Stephen M , Klevens R Monina , Barnett Michael L , Grad Yonatan H 
Published: March 2020

Abstract

Background
The mechanisms driving the recent decline in outpatient antibiotic prescribing are unknown. We estimated the extent to which reductions in the number of antibiotic prescriptions filled per outpatient visit (stewardship) and reductions in the monthly rate of outpatient visits (observed disease) for infectious disease conditions each contributed to the decline in outpatient antibiotic prescribing in Massachusetts between 2011 and 2015.

Methods
Outpatient medical and pharmacy claims from the Massachusetts All-Payer Claims Database were used to estimate rates of antibiotic prescribing and outpatient visits for 20 medical conditions and their contributions to the overall decline in antibiotic prescribing. Trends were compared with those in the National Ambulatory Medical Care Survey (NAMCS).

Results
Between 2011 and 2015, the January and July antibiotic-prescribing rates per 1000 individuals in Massachusetts declined by 18.9% and 13.6%, respectively. The monthly rate of outpatient visits per 1000 individuals in Massachusetts declined (P &lt; .05) for respiratory infections and urinary tract infections. Nationally, outpatient visits for antibiotic-meriting medical conditions also declined between 2010 and 2015. Of the estimated 358 antibiotic prescriptions per 1000 individuals averted over the study period in Massachusetts, 59% (95% CI, 54–63%) were attributable to reduced observed disease and 41% (95% CI, 37–46%) to improved stewardship.

Conclusions
The decline in antibiotic prescribing in Massachusetts was driven both by a decline in observed disease and improved antibiotic stewardship, in agreement with national trends. A focus on infectious disease prevention should be considered alongside antibiotic stewardship as a means to reduce antibiotic prescribing.
Novel Coronavirus Disease 2019 (COVID-19) Pneumonia Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section Computed Tomography Features During Recovery
Authors: Han Xiaoyu , Cao Yukun , Jiang Nanchuan , Chen Yan , Alwalid Osamah , Zhang Xin , Gu Jin , Dai Meng , Liu Jie , Zhu Wanyue , Zheng Chuansheng , Shi Heshui 
Published: March 2020

Abstract

Background
Our objective was to retrospectively analyze the evolution of clinical features and thin-section computed tomography (CT) imaging of novel coronavirus disease 2019 (COVID-19) pneumonia in 17 discharged patients.

Methods
Serial thin-section CT scans of 17 discharged patients with COVID-19 were obtained during recovery. Longitudinal changes of clinical parameters and a CT pattern were documented in all patients during the 4 weeks after admission. A CT score was used to evaluate the extent of the disease.

Results
There were marked improvements of fever, lymphocyte counts, C-reactive proteins, and erythrocyte sedimentation rates within the first 2 weeks after admission. However, the mean CT score rapidly increased from the first to the third week, with a top score of 8.2 obtained in the second week. During the first week, the main CT pattern was ground-glass opacities (GGO; 76.5%). The frequency of GGO (52.9%) decreased in the second week. Consolidation and mixed patterns (47.0%) were noted in the second week. Thereafter, consolidations generally dissipated into GGO, and the frequency of GGO increased in the third week (76.5%) and fourth week (71.4%). Opacities were mainly located in the peripheral (76.5%) and subpleural (47.1%) zones of the lungs; they presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third weeks (58.8%), then showed a reduced extent in fourth week (50%).

Conclusions
The progression course of the CT pattern was later than the progression of the clinical parameters within the first 2 weeks after admission; however, there were synchronized improvements in both the clinical and radiologic features in the fourth week.
Divergent male and female mate preferences do not explain incipient speciation between lizard lineages
Authors: McLean Claire A , Bartle Richard A , Dong Caroline M , Rankin Katrina J , Stuart-Fox Devi 
Published: March 2020

Abstract
Diversification in sexual signals is often taken as evidence for the importance of sexual selection in speciation. However, in order for sexual selection to generate reproductive isolation between populations, both signals and mate preferences must diverge together. Furthermore, assortative mating may result from multiple behavioral mechanisms, including female mate preferences, male mate preferences, and male–male competition; yet their relative contributions are rarely evaluated. Here, we explored the role of mate preferences and male competitive ability as potential barriers to gene flow between 2 divergent lineages of the tawny dragon lizard, Ctenophorus decresii, which differ in male throat coloration. We found stronger behavioral barriers to pairings between southern lineage males and northern lineage females than between northern males and southern females, indicating incomplete and asymmetric behavioral isolating barriers. These results were driven by both male and female mate preferences rather than lineage differences in male competitive ability. Intrasexual selection is therefore unlikely to drive the outcome of secondary contact in C. decresii, despite its widely acknowledged importance in lizards. Our results are consistent with the emerging view that although both male and female mate preferences can diverge alongside sexual signals, speciation is rarely driven by divergent sexual selection alone.
Anomalous origin of coronary arteries from pulmonary artery in adults: a case series
Authors: Vergara-Uzcategui Carlos Eduardo , das Neves Barbara , Salinas Pablo , Fernández-Ortiz Antonio , Núñez-Gil Iván J 
Published: March 2020

Abstract

Background
Anomalous origin of a coronary artery from the pulmonary trunk is a small group of rare congenital anomalies present in up to 1% of the population. These patients, in absence of an adequate collateral supply, may present with congestive heart failure secondary to ischaemia, arrhythmia, or sudden cardiac death in up to 90% of cases within the first months of life.

Case summary
We present four cases diagnosed in adulthood over 10 years in two high-volume centres. The first patient presented with dyspnoea and orthopnoea. The second with chest pain and episodes of non-sustained ventricular tachycardia. The third patient presented during her third pregnancy with chest pain, palpitations, and arrhythmia (non-sustained ventricular tachycardia). The fourth patient presented with sudden cardiac death.

Discussion
In all cases with anomalous origin of coronary arteries, it is recommendable to consider surgical correction to avoid the progression of ischaemia, congestive heart failure, arrhythmia, and sudden death.
Atypical haemolytic uraemic syndrome: a case report of a rare cause of reversible cardiomyopathy
Authors: Campbell Courtney M , Cassol Clarissa , Cataland Spero R , Kahwash Rami 
Published: March 2020

Abstract

Background
Atypical haemolytic uraemic syndrome (aHUS) is a life-threatening, genetic disease of complement-mediated thrombotic microangiopathy that typically presents as anaemia, thrombocytopenia, and renal failure. Cardiomyopathy is seen in up to 10% of aHUS cases, but the aetiology is not well-understood.

Case summary
A 63-year-old man recently was diagnosed with a thrombotic microangiopathy most consistent with aHUS by renal biopsy after presentation with acute renal failure requiring haemodialysis. He was started on therapy with complement inhibitor, eculizumab. Six weeks after diagnosis, he presented with progressive dyspnoea on exertion and chest pain. An echocardiogram demonstrated an acute drop in left ventricular ejection fraction to 20–25% with global hypokinesis. Left heart catheterization showed moderate, non-obstructive coronary artery disease. Cardiac magnetic resonance imaging demonstrated diffuse myocardial oedema. Endomyocardial biopsy revealed an arteriole with obliterative changes and a few possible fragmented red blood cells suggestive of thrombotic microangiopathy. There was no biopsy evidence of immune complex deposition or myocarditis. He was treated for heart failure and was maintained on eculizumab. On repeat echocardiogram 3 months later, the patient had complete recovery of his ejection fraction (60–65%).

Discussion
In this report, we describe complete recovery of aHUS-associated heart failure with eculizumab therapy and demonstrate for the first time that the aetiology of aHUS-associated heart failure is likely an acute thrombotic microangiopathy involving small intramyocardial arterioles, as demonstrated by cardiac biopsy.
Gaps in patient-reported outcome measures in randomized clinical trials of cardiac catheter ablation: a systematic review
Authors: Chen Yang , Nagendran Myura , Gomes Manuel , Wharton Peter V , Raine Rosalind , Lambiase Pier D 
Published: March 2020

Abstract
The aim of this systematic review was to evaluate randomized clinical trials (RCTs) of cardiac catheter ablation (CCA) and to assess the prevalence, characteristics and reporting standards of clinically relevant patient-reported outcome measures (PROMs). Electronic database searches of Medline, Embase, CENTRAL, and the WHO Trial Registry were conducted in March 2019. The study protocol was registered on PROSPERO (CRD42019133086). Of 7125 records identified, 237 RCTs were included for analysis, representing 35 427 patients with a mean age of 59 years. Only 43 RCTs (18%) reported PROMs of which 27 included a generic PROM that measured health-related quality of life (HRQL) necessary to conduct comparative effectiveness research. There was notable under-representation of certain patient groups—only 31% were women and only 8% were of non-Caucasian ethnicity, in trials which reported such data. The reporting standard of PROMs was highly variable with 8–62% adherence against CONSORT PRO-specific items. In summary, PROMs play a crucial role in determining the clinical and cost-effectiveness of treatments which primarily offer symptomatic improvement, such as CCA. Their underuse significantly limits evaluation of the comparative effectiveness of treatments. Using CCA as an exemplar, there are additional issues of infrequent assessment, poor reporting and under-representation of many population groups. Greater use of PROMs, and specifically validated HRQL questionnaires, is paramount in giving patients a voice in studies, generating more meaningful comparisons between treatments and driving better patient-centred clinical and policy-level decision-making.
The mixology of precursory strain partitioning approaching brittle failure in rocks
Authors: McBeck J , Ben-Zion Y , Renard F 
Published: March 2020

SUMMARYWe examine the strain accumulation and localization process throughout 12 triaxial compression experiments on six rock types deformed in an X-ray transparent apparatus. In each experiment, we acquire 50–100 tomograms of rock samples at differential stress steps during loading, revealing the evolving 3-D distribution of X-ray absorption contrasts, indicative of density. Using digital volume correlation (DVC) of pairs of tomograms, we build time-series of 3-D incremental strain tensor fields as the rocks are deformed towards failure. The Pearson correlation coefficients between components of the local incremental strain tensor at each stress step indicate that the correlation strength between pairs of local strain components, including dilation, contraction and shear strain, are moderate-strong in 11 of 12 experiments. In addition, changes in the local strain components from one DVC calculation to the next show differences in the correlations between pairs of strain components. In particular, the correlation of the local changes in dilation and shear strain tends to be stronger than the correlation of changes in dilation-contraction and contraction-shear strain. In 11 of 12 experiments, the most volumetrically frequent mode of strain accommodation includes a synchronized increase in multiple strain components. Early in loading, under lower differential stress, the most frequent strain accumulation mode involves the paired increase in dilation and contraction at neighbouring locations. Under higher differential stress, the most frequent mode is the paired increase in dilation and shear strain. This mode is also the first or second most frequent throughout each complete experiment. Tracking the mean values of the strain components in the sample and the volume of rock that each component occupies reveals fundamental differences in the nature of strain accumulation and localization between the volumetric and shear strain modes. As the dilative strain increases in magnitude throughout loading, it tends to occupy larger volumes within the rock sample and thus delocalizes. In contrast, the increasing shear strain components (left- or right-lateral) do not necessarily occupy larger volumes and so involve localization. Consistent with these evolutions, the correlation length of the dilatational strains tends to increase by the largest amounts of the strain components from lower to higher differential stress. In contrast, the correlation length of the shear strains does not consistently increase or decrease with increasing differential stress.
Reviewing the Potential of Psychedelics for the Treatment of PTSD
Authors: Krediet Erwin , Bostoen Tijmen , Breeksema Joost , van Schagen Annette , Passie Torsten , Vermetten Eric 
Published: March 2020

Abstract
There are few medications with demonstrated efficacy for the treatment of posttraumatic stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy as a first line treatment for PTSD. Yet, even after psychotherapy, PTSD often remains a chronic illness, with high rates of psychiatric and medical comorbidity. Meanwhile, the search for and development of drugs with new mechanisms of action has stalled. Therefore, there is an urgent need to explore not just novel compounds but novel approaches for the treatment of PTSD. A promising new approach involves the use of psychedelic drugs. Within the past few years, 2 psychedelics have received breakthrough designations for psychiatric indications from the US Food and Drug Administration, and several psychedelics are currently being investigated for the treatment of PTSD. This review discusses 4 types of compounds: 3,4-methylenedioxymethamphetamine, ketamine, classical psychedelics (e.g., psilocybin and lysergic acid diethylamide), and cannabinoids. We describe the therapeutic rationale, the setting in which they are being administered, and their current state of evidence in the treatment of PTSD. Each compound provides unique qualities for the treatment of PTSD, from their use to rapidly target symptoms to their use as adjuncts to facilitate psychotherapeutic treatments. Several questions are formulated that outline an agenda for future research.
Strong convergence of a half-explicit Euler scheme for constrained stochastic mechanical systems
Authors: Lindner Felix , Stroot Holger 
Published: March 2020

AbstractThis paper is concerned with the numerical approximation of stochastic mechanical systems with nonlinear holonomic constraints. The considered systems are described by second-order stochastic differential-algebraic equations involving an implicitly given Lagrange multiplier process. The explicit representation of the Lagrange multiplier leads to an underlying stochastic ordinary differential equation, the drift coefficient of which is typically not globally one-sided Lipschitz continuous. We investigate a half-explicit, drift-truncated Euler scheme that fulfills the constraint exactly. Pathwise uniform $L_p$-convergence is established. The proof is based on a suitable decomposition of the discrete Lagrange multipliers and on norm estimates for the single components, enabling the verification of consistency, semistability and moment growth properties of the scheme.
Rapid Kinetic Spectrophotometric Determination of Phosalone (Zolone) in a Commercial Formulation
Authors: Espinosa-Mansilla Anunciación , Cabanillas Agustina Guiberteau , Salinas Francisco , Mora Nielena , Zamoro Angel 
Published: March 2020

Abstract
A kinetic study of the degradation of phosalone in an alkaline medium was undertaken by using a pneumatic stopped-flow system. A rapid semiautomatic method is proposed for determining phosalone. Linear calibration graphs up to 8.0 × 10−5M (detection limit = 1.40 × 10−6M) were obtained, with a measurement period of only 3.5 s per sample and a relative standard deviation of 1.4%. Several pesticides were assayed as interference species, and several did not interfere even at a 6:1, M:M foreign species/phosalone ratio. A strong interference (ratio &lt; 1) was generated by azinphos-methyl and carbaryl. The proposed method was applied to the analysis of a commercial formulation, and the results were validated by comparison with those for a chromatographic method.
Determination of Egg Proteins in Food Products by Enzyme Immunoassay
Authors: Yeung Jupiter M , Newsome W Harvey , Abbott Michael A 
Published: March 2020

Abstract
An enzyme-linked immunosorbent assay (ELISA) was developed to determine the presence of egg proteins in foods. The polyclonal antibodies developed were specific to whole egg proteins and did not cross-react with any of the 38 nuts, legumes, or other common food ingredients tested. The concentrations of egg proteins that will inhibit 50% of antibody–antigen binding, IC50, were 3–7 ng/mL, and the linear range was 0.5–62.5 ng/mL. The detection limit was 0.2 ppm for various foods. Recoveries ranged from 67 to 96%. The intra- and inter-assay coefficients of variation in this procedure were 10–13% for ice cream spiked at 0.8 and 1.6 ppm. The ELISA has been applied to ice creams, noodles, pasta, and breads. Egg proteins were identified in all declared egg products, and no false positives were found.
Determination of Malathion, Coumaphos, and Fluvalinate Residues in Honey by Gas Chromatography with Nitrogen–Phosphorus or Electron Capture Detectors
Authors: Menkissoglu-Spiroudi Urania , Diamantidis Grigorios C , Georgiou Vassiliki E , Thrasyvoulou Andreas T 
Published: March 2020

Abstract
A rapid, reliable, and inexpensive extraction method was developed to determine acaricide residues in honey by gas chromatography (GC) with nitrogen–phosphorus (NP) or electron capture (EC) detectors. Because of the high selectivity of the NP detector, no interfering peaks were present and no cleanup was necessary. A simple cleanup step is proposed for the GC–ECD analysis. Recoveries from spiked honey samples ranged from 79 to 94.4%, with coefficients of variation of 0.3–18.5%. The quantitation limit obtained was 0.015 mg/kg for malathion, 0.020 mg/kg for coumaphos, and 0.005 mg/kg for fluvalinate. The method was used to determine the disappearance of malathion and coumaphos residues from honey samples collected from beehives treated with these acaricides. The disappearance of both acaricides was rapid and followed a first-order model for the duration of the experiment.
Determination of Six Metals in Galician Red Wines (in Northwestern Spain) by Capillary Electrophoresis
Authors: Núñez Mar , Peña Rosa M , Herrero Carlos , García Sagrario 
Published: March 2020

Abstract
A simple technique is described for the routine simultaneous capillary electrophoretic determination of 6 cations in wine. Separation was achieved on a fused silica capillary column with a UV-Cat-1, α-hydroxysobutyric acid and 18-crown-6-ether buffer at pH 4.5 and indirect UV detection at 214 nm. The content of magnesium, sodium, potassium, calcium, manganese, and lithium was determined. The method is quantitative, with recoveries in the 92–102% range, and linear over more than one order of magnitude. The precision is better than 2.5–3.4%. The method is sensible, with detection limits between 0.01 and 0.06 mg/L. Twenty-five red wines with a Certified Brand of Origin from Galicia (northwestern Spain) were analyzed by the proposed method. Various wines showed very similar electrophoretic profiles, but significant quantitative differences were observed.
Determination of 4-Hexylresorcinol in Shrimp by Liquid Chromatography with Fluorescence Detection
Authors: Jonker Klaas M , Dekker Colinda P 
Published: March 2020

Abstract
A method was developed to determine 4-hexylresorcinol in shrimp meat. The procedure is based on extraction of test portions with methanol followed by liquid chromatographic analysis of the extracts, using a reversed-phase column and fluorimetric detection (excitation: 280 nm, and emission: 310 nm). The confidence interval of the recovery in working range of 1.5–2.5 mg/kg was 81.6 ± 0.8%. The relative standard deviation in the working range was 2.1%. Limits of quantitation and detection were 6.59 and 1.98 ng/mL extract, respectively, corresponding to 0.26 and 0.08 mg/kg in shrimp.
New Monitoring System for Ninety Pesticides and Related Compounds in River Water by Solid-Phase Extraction with Determination by Gas Chromatography/Mass Spectrometry
Authors: Tanabe Akiko , Mitobe Hideko , Kawata Kuniaki , Sakai Masaaki , Yasuhara Akio 
Published: March 2020

Abstract
A new monitoring system was established for the determination of 90 pesticides and 10 pesticide degradation products in river water. The pesticides consisted of 18 fungicides, 30 insecticides, and 42 herbicides. The pesticides were extracted with a solid-phase, styrene-divinylbenzene copolymer, eluted with acetone, hexane, and ethyl acetate, and determined by gas chromatography/mass spectrometry. Overall recoveries ranged from 72 to 118%. The limits of detection were 0.01–0.1 μg/L. This system determines most of the pesticides used in Japan and was successfully applied to practical monitoring of water polluted with pesticides and related compounds.
Detection of Pork in Heat-Processed Meat Products by Monoclonal Antibody-Based ELISA
Authors: Chen Fur-Chi , Hsieh Y-H Peggy 
Published: March 2020

Abstract
An enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody to a porcine thermal-stable muscle protein was developed for detection of pork in cooked meat products. The assay specifically detects porcine skeletal muscle, but not cardiac muscle, smooth muscle, blood, and nonmuscle organs. No cross-reactivity was observed with common food proteins. Validity of the assay was evaluated with laboratory formulated and commercial meat samples. The detection limit was determined as 0.5% (w/w) pork in heterologous meat mixtures. Overall, intra- and inter-assay coefficients of variation were 5.8 and 7.9%, respectively. The accuracy in analyzing market samples was 100% as verified by product labeling and confirmed by a commercial polycolonal antibody test kit.