bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation process of a high‐resolution database in a paediatric intensive care unit—Describing the perpetual patient's validation
Authors: Mathieu Audrey , Sauthier Michael , Jouvet Philippe , Emeriaud Guillaume , Brossier David 
Published: May 2020

AbstractRationaleHigh data quality is essential to ensure the validity of clinical and research inferences based on it. However, these data quality assessments are often missing even though these data are used in daily practice and research.Aims and objectivesOur objective was to evaluate the data quality of our high‐resolution electronic database (HRDB) implemented in our paediatric intensive care unit (PICU).MethodsWe conducted a prospective validation study of a HRDB in a 32‐bed paediatric medical, surgical, and cardiac PICU in a tertiary care freestanding maternal‐child health centre in Canada. All patients admitted to the PICU with at least one vital sign monitored using a cardiorespiratory monitor connected to the central monitoring station.ResultsBetween June 2017 and August 2018, data from 295 patient days were recorded from medical devices and 4645 data points were video recorded and compared to the corresponding data collected in the HRDB. Statistical analysis showed an excellent overall correlation (R2 = 1), accuracy (100%), agreement (bias = 0, limits of agreement = 0), completeness (2% missing data), and reliability (ICC = 1) between recorded and collected data within clinically significant pre‐defined limits of agreement. Divergent points could all be explained.ConclusionsThis prospective validation of a representative sample showed an excellent overall data quality.
Erythrosine B (Red Dye No. 3): A potential photosensitizer for the photodynamic inactivation of foodborne pathogens in tomato juice
Authors: Cho Ga‐Lam , Ha Jae‐Won 
Published: May 2020

AbstractThe objectives of this study were to evaluate the efficacy of erythrosine B (ERY, Red No. 3)‐mediated photodynamic therapy (PDT) for inactivating Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes in tomato juice. The inoculated tomato juice was subjected to xenon light (E − L+), ERY (E + L−), or xenon light and ERY combination (E + L+) treatments. Treatment with E + L+ for 15 min decreased the cell counts of E. coli O157:H7, S. Typhimurium, and L. monocytogenes by 6.77, 2.74, and 6.43 log CFU/mL, respectively, without generating sublethally injured cells. The cell count reductions of E. coli O157:H7 and L. monocytogenes in the E + L+ treatment group were higher than the sum of cell count reductions in the E − L+ and E + L− treatment groups, which indicated the synergistic activity of the treatment combination. The T3d and T5d values calculated by the Weibull model indicated that S. Typhimurium exhibited higher resistance to the E + L+ treatment than the other two pathogens. Compared with control group, the E + L+ treatment group exhibited higher lycopene content and a* (red) value, whereas the pH value and sensory attributes were not significantly (p > .05) altered. These results suggest that ERY‐mediated PDT can be potentially applied to control foodborne pathogens in tomato juice products without negatively affecting the product quality.
Transforming Undergraduate Student Perceptions of Dementia through Music and Filmmaking
Authors: Gubner Jennie , Smith Alexander K. , Allison Theresa A. 
Published: May 2020

BACKGROUNDWith nearly 6 million people with dementia (PWD) in the United States, there is a critical need to build an interprofessional dementia workforce. Among the novel approaches to expanding a new workforce, music and the arts show promise for engaging students and trainees. To understand how and why the arts affect attitudes about and engagement with PWD, we examined a service‐learning general education undergraduate course centering on music, filmmaking, and dementia.METHODSThe undergraduate course curriculum brought students to meet with PWD in dementia care settings, build personalized music playlists, coproduce short films about PWD, and write reflective essays. Two researchers independently completed inductive thematic analysis of the films, essays, and course evaluations. Differences were reconciled by consensus.RESULTSA total of 52 students from three classes completed the course; 24 (46%) were majoring in health sciences. Three key themes emerged: (1) Music helps students connect with people living with dementia in meaningful ways; (2) filmmaking offers students the opportunity to share unique, person‐centered stories about dementia and music that empower the voices of PWD; and (3) reflective writing enables students to process new experiences and lessons learned. Unexpectedly, 29 students (56%) reported continued engagement with PWD in their careers, families, and communities after course completion.CONCLUSIONThis study identifies reproducible ways in which undergraduate arts courses thematically focused on dementia not only transform student perceptions about dementia but change the ways in which those students choose to engage with PWD following course completion. Arts and music departments may represent an untapped resource for building a geriatrics workforce. J Am Geriatr Soc 68:1083–1089, 2020
Choosing Inpatient vs Home Treatment: Why Patients Accept or Decline Hospital at Home
Authors: Saenger Pamela , Federman Alex D. , DeCherrie Linda V. , Lubetsky Sara , Catalan Elisse , Leff Bruce , Siu Albert L. 
Published: May 2020

BACKGROUND/OBJECTIVESHospital at home (HaH) provides interdisciplinary acute care in the home as a substitute for inpatient hospitalization. Studies have demonstrated that HaH care is associated with better quality care, fewer complications, and better patient and caregiver experience. Still, some patients decline HaH. The objective of the study was to characterize patients who accept vs decline HaH care and describe reasons for their decisions in the context of a Center for Medicare and Medicaid Innovation demonstration of HaH.DESIGN/SETTING/PARTICIPANTSA total of 442 patients with Medicare or other eligible insurance, 18 years or older, who met study eligibility criteria were offered HaH at Mount Sinai Hospitals in New York, NY, between September 1, 2014, and August 31, 2017.MEASUREMENTSReasons for accepting or declining HaH were recorded. Age, sex, insurance type, and admission diagnoses of HaH acceptors and refusers were compared in univariate analyses.RESULTSOf the 442 patients offered HaH, 66.7% accepted. Main reasons for enrolling in HaH included being more comfortable at home (78.2%) and being near family (40.7%). Specific reasons given for refusing HaH included preferring in‐hospital care (15.0%) and concern that HaH would not meet care needs (12.9%).CONCLUSIONTwo‐thirds of patients offered HaH care opted to receive it. The reasons for declining HaH provided by those who chose not to participate should be considered for quality improvement, and reasons for acceptance may be helpful in marketing and other efforts to promote HaH participation. J Am Geriatr Soc 68:1579‐1583, 2020.
Tumour biomarkers: association with heart failure outcomes
Authors: Shi C. , van der Wal H. H. , Silljé H. H. W. , Dokter M. M. , van den Berg F. , Huizinga L. , Vriesema M. , Post J. , Anker S. D. , Cleland J. G. , Ng L. L. , Samani N. J. , Dickstein K. , Zannad F. , Lang C. C. , van Haelst P. L. , Gietema J. A. , Metra M. , Ameri P. , Canepa M. , van Veldhuisen D. J. , Voors A. A. , de Boer R. A. 
Published: May 2020

AbstractBackgroundThere is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics.ObjectivesTo explore the association between tumour biomarkers and HF outcomes.MethodsIn 2,079 patients of BIOSTAT‐CHF cohort, we measured six established tumour biomarkers: CA125, CA15‐3, CA19‐9, CEA, CYFRA 21‐1 and AFP.ResultsDuring a median follow‐up of 21 months, 555 (27%) patients reached the primary end‐point of all‐cause mortality. CA125, CYFRA 21‐1, CEA and CA19‐9 levels were positively correlated with NT‐proBNP quartiles (all P < 0.001, P for trend < 0.001) and were, respectively, associated with a hazard ratio of 1.17 (95% CI 1.12–1.23; P < 0.0001), 1.45 (95% CI 1.30–1.61; P < 0.0001), 1.19 (95% CI 1.09–1.30; P = 0.006) and 1.10 (95% CI 1.05–1.16; P < 0.001) for all‐cause mortality after correction for BIOSTAT risk model (age, BUN, NT‐proBNP, haemoglobin and beta blocker). All tumour biomarkers (except AFP) had significant associations with secondary end‐points (composite of all‐cause mortality and HF hospitalization, HF hospitalization, cardiovascular (CV) mortality and non‐CV mortality). ROC curves showed the AUC of CYFRA 21‐1 (0.64) had a noninferior AUC compared with NT‐proBNP (0.68) for all‐cause mortality (P = 0.08). A combination of CYFRA 21‐1 and NT‐proBNP (AUC = 0.71) improved the predictive value of the model for all‐cause mortality (P = 0.0002 compared with NT‐proBNP).ConclusionsSeveral established tumour biomarkers showed independent associations with indices of severity of HF and independent prognostic value for HF outcomes. This demonstrates that pathophysiological pathways sensed by these tumour biomarkers are also dysregulated in HF.
Cerebral Perfusion Does Not Increase after Shunt Surgery for Normal Pressure Hydrocephalus
Authors: Virhammar Johan , Ahlgren André , Cesarini Kristina G. , Laurell Katarina , Larsson Elna‐Marie 
Published: May 2020

ABSTRACTBACKGROUND AND PURPOSECerebral blood flow (CBF) has been reported to increase after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). The aims of this study were to investigate if CBF, measured using the noninvasive perfusion MRI method arterial spin labeling (ASL), increased after shunt surgery, if postoperative change in CBF correlated with improvement in symptoms, and if baseline CBF data correlated with postoperative outcome.METHODSTwenty‐three patients with iNPH were prospectively included and examined with MRI of the brain and clinical tests of symptoms at baseline. Eighteen of the patients were treated with shunt implantation and were reexamined with clinical tests and MRI 3 months postoperatively. The MRI protocol included a pseudo‐continuous ASL sequence for perfusion imaging. The perfusion was measured in 12 manually drawn regions of interest (ROIs).RESULTSIn the whole sample, CBF did not increase after shunting in any ROI. Preoperative CBF in medial frontal cortex correlated with an improvement in urinary incontinence after shunt surgery, r = .53, P = .022. There were no correlations between change in CBF and change in clinical symptoms postoperatively.CONCLUSIONSThe clinical value of ASL in the work‐up of patients with iNPH is uncertain. In this study, ASL could not predict outcome after shunt surgery and there were no correlations between change in CBF and change in clinical symptoms after shunt surgery.
Activity of four nematicides against Meloidogyne incognita race 2 on tomato plants
Authors: Yue Xiangguo , Li Fahui , Wang Bingtai 
Published: May 2020

AbstractMeloidogyne incognita is one of the most important causes of disease in protected vegetable cultivation in North China Plain, but chemical control options for it are currently limited. In the present study, we measured activity of four nematicides with M. incognita race 2 in the laboratory and greenhouse pots. Fluensulfone and fluopyram had a greater negative effect on the motility of M. incognita second‐stage juveniles (J2) than avermectin B1a (AV‐B1a) and fosthiazate had, especially at low concentration, with respective EC50 values of 0.29, 0.13, 0.68 and 2.48 mg/L. AV‐B1a significantly and uniquely inhibited egg hatching, which indicated that it was the only nematicide that could readily be transported across the eggshell. In greenhouse pots, fluensulfone (10 mg−1) and fluopyram (1 and 10 mg−1) caused the greatest inhibition of formation of galls in tomato roots, with decreases of 98.6%, 96.2% and 99.2%, respectively. This indicated that some M. incognita J2 lost their root penetration ability without losing their motility.
Patient‐specific finite element models of the human mandible: Lack of consensus on current set‐ups
Authors: Merema Bram Barteld Jan , Kraeima Joep , Glas Haye H. , Spijkervet Fred K. L. , Witjes Max J. H. 
Published: May 2020

AbstractThe use of finite element analysis (FEA) has increased rapidly over the last decennia and has become a popular tool to design implants, osteosynthesis plates and prostheses. With increasing computer capacity and the availability of software applications, it has become easier to employ the FEA. However, there seems to be no consensus on the input variables that should be applied to representative FEA models of the human mandible. This review aims to find a consensus on how to define the representative input factors for a FEA model of the human mandible. A literature search carried out in the PubMed and Embase database resulted in 137 matches. Seven papers were included in this current study. Within the search results, only a few FEA models had been validated. The material properties and FEA approaches varied considerably, and the available validations are not strong enough for a general consensus. Further validations are required, preferably using the same measuring workflow to obtain insight into the broad array of mandibular variations. A lot of work is still required to establish validated FEA settings and to prevent assumptions when it comes to FEA applications.
Simultaneous occurrence of cutaneous mastocytosis and juvenile xanthogranuloma in a child: Random or true association?
Authors: Vergara‐de‐la‐Campa Laura , Torrelo Antonio , Isabel Sánchez‐Moya Ana , Recuero‐Pradillo María , Mollejo Manuela , Matito Almudena 
Published: May 2020

AbstractJuvenile xanthogranuloma (JXG) and cutaneous mastocytosis (CM) are two distinct conditions that have rarely been reported in association. We report a child with CM and disseminated JXG, who showed a significant decrease in serum tryptase levels and regression of JXG lesions over time. Due to the paucity of reports, a true association between these two conditions has not been validated, although a potential induction of histiocytic lesions by mast cell degranulation has been proposed.
Oral hairy leukoplakia in a child using a corticosteroid nasal spray
Authors: Costa Fernanda Herrera , Costa Victor , León Jorge Esquiche , Anbinder Ana Lia , Ribeiro‐Silva Alfredo , Kaminagakura Estela 
Published: May 2020

AbstractWe report a case of atypical oral hairy leukoplakia (OHL) in a 9‐year‐old immunocompetent girl treated with fluticasone propionate nasal spray for allergic rhinitis. The OHL in childhood is uncommon and should be included in a differential diagnosis of white lesions in the oral mucosa.
Novel variants in Turkish patients with glycogen storage disease
Authors: Çakar Nafiye Emel , Gezdirici Alper , Topuz Hanım Şeyma , Önal Hasan 
Published: May 2020

AbstractBackgroundGlycogen storage diseases (GSD) are disorders of autosomal recessive carbohydrate metabolism, characterized by glycogen accumulation. The liver and muscle tissue are commonly affected but patients may present with different clinical manifestations. The presence of glycogen can be demonstrated in biopsies and definitive diagnosis can be made by enzymatic or molecular analysis. The aim of this study was to determine specific gene mutations in our cases with GSD.MethodsThirty‐eight patients with clinical and laboratory diagnoses of GSD were studied. Thirty‐two patients had undergone genetic analysis. In our study, a next‐generation sequencing panel was used.ResultsFive novel variants of uncertain significance (VUS), which were likely to be pathogenic, were detected in seven patients. Two new pathogenic variations of c.927delT (p.Phe309LeufsTer4) homozygous and c.44C>G (p.Ser15Ter) homozygous in the G6PC gene were detected in two GSD type Ia patients. In our two non‐sibling GSD type III patients, c.1439T>G (p.Leu480Arg) homozygous novel‐VUS was detected in the AGL gene. In our GSD type IV patient, c.1054G>C (p.Asp352His) homozygous novel‐VUS was detected in the GBE1 gene. In GSD type VI, two sibling patients had a c.1454A>G (p.Asn485Ser) homozygous novel‐VUS change in the PYGL gene.ConclusionsWe determined the gene mutations specific to cohorts in our cases with GSD. The novel pathogenic, likely pathogenic, and VUS changes identified will contribute to the relationship between the patients’ clinical and laboratory findings.
Possible selves, psychological well‐being, and substance use in young men within 12 months post‐incarceration
Authors: Johnson Amy , Corte Colleen , Culbert Gabriel , Finnegan Lorna , Tarlov Elizabeth , Maskaly Jon , Lusk Brigid 
Published: May 2020

AbstractObjectiveCommunity reentry post‐incarceration is fraught with challenges. The investigators examined the influence of highly personalized goals (possible selves) on psychological well‐being, drug use, and hazardous drinking in recently incarcerated young men returning to the community.Design and SampleIn this cross‐sectional study, 52 young men released from jail or prison within the past 12 months were recruited from community‐based organizations and reentry events.MeasurementsParticipants completed open‐ended possible selves measure and psychological well‐being and substance use questionnaires.ResultsPossible selves accounted for 19%–31% of the variance in sense of purpose, environmental mastery, and personal growth. Having a feared delinquent possible self was associated with lower sense of purpose. Having many feared possible selves was associated with lower environmental mastery. Having an expected possible self related to interpersonal relationships was associated with higher personal growth and environmental mastery. Men having a feared delinquent possible self or an expected possible self related to material/lifestyle were more likely to use marijuana than men who did not.ConclusionThe content and number of possible selves may be an important focus for assessment by public health nurses in correctional and community settings serving young men post‐incarceration. Longitudinal studies with larger samples are needed.
Beyond the Turtle Approach: Women in the Public Sector
Authors: Neal Sue M. , Gherardi Michelle R. , Olejarski Amanda M. 
Published: May 2020

AbstractEquity issues persist in defining public sector women as in need of accommodation, including during times of child‐rearing or caregiving. The authors argue instead that viewing the fullness of a woman's existence should empower others to see broad life experiences as a benefit to be fostered. Public service organizations and the academy should build policies and systems that recognize this value and work to cultivate, rather than accommodate. While women have historically taken the turtle approach—that is, keep your head down—the #MeToo movement has morphed women into strong bison, standing shoulder to shoulder. The authors advocate for more inclusive and supportive mentoring relationships to move into a new era—the pigeon era. In public administration, this manifests as providing holistic support and intentional mentorships throughout the arc of women's careers and institutional policy changes that support the unique value of women in the public sector and the academy.
Seasonal variation in testicular blood flow dynamics and their relation to systemic and testicular oxidant/antioxidant biomarkers and androgens in rams
Authors: Hedia Mohamed G. , El‐Belely Mohamed S. , Ismail Sayed T. , Abo El‐Maaty Amal M. 
Published: May 2020

AbstractThe environmental temperature increased during summer and decreased during winter to the limits that might negatively affect animal and human reproduction. The responses of Egyptian rams to either hot or cold climatic conditions were studied in six mature rams subjected to weekly testicular Doppler ultrasonographic examination, blood sampling, seminal plasma collection and semen evaluation. The maximum environmental temperature and the relative humidity were used to classify the climatic condition according to the heat stress equation of sheep into hot months where temperature–humidity index (THI) was >26 (31.67 ± 0.54), and cold months where THI was <22 (18.39 ± 0.41). Testosterone, estradiol, superoxide dismutase (SOD), glutathione peroxidase (GPX) and lipid peroxide product (malondialdehyde, MDA) were measured in both blood and seminal plasma, while catalase (CAT) and reduced glutathione (GSH) were measured in blood and seminal plasma, respectively. Results revealed that, during the hot months, rams displayed significantly decreased testicular blood flow, increased seminal plasma MDA, decreased seminal plasma (SOD, GPx and GSH) and blood CAT antioxidant enzymes. The present study evidenced two novel findings: (a) the marked decrease in testicular blood flow volume, that is remarkable increase in both resistive index (RI) and pulsatility index (PI) values, during hot months could be negatively affected both seminal plasma enzymatic activities and seminal attributes, and (b) the SOD and GPx activities in seminal plasma of such animals were suitable predictive markers for seminal attribute evaluation.
Unbiased Markov Chain Monte Carlo Methods with Couplings
Authors: Jacob Pierre E. , O’Leary John , Atchadé Yves F. 
Published: May 2020

SummaryMarkov chain Monte Carlo (MCMC) methods provide consistent approximations of integrals as the number of iterations goes to ∞. MCMC estimators are generally biased after any fixed number of iterations. We propose to remove this bias by using couplings of Markov chains together with a telescopic sum argument of Glynn and Rhee. The resulting unbiased estimators can be computed independently in parallel. We discuss practical couplings for popular MCMC algorithms. We establish the theoretical validity of the estimators proposed and study their efficiency relative to the underlying MCMC algorithms. Finally, we illustrate the performance and limitations of the method on toy examples, on an Ising model around its critical temperature, on a high dimensional variable-selection problem, and on an approximation of the cut distribution arising in Bayesian inference for models made of multiple modules.
Mapping Memory and Historical Literacy onto the German Curriculum
Authors: Wagner Susanne M. , Hoecherl‐Alden Gisela 
Published: May 2020

AbstractMore than ever, faculty need to ensure that undergraduate curricula not only provide students with tools to gain linguistic proficiency but also teach them to analyze both written and visual information to attain historical literacy. Developing both intercultural proficiency and insights into various historical memorialization processes ensures that students can identify intertextual references, appreciate how their own culture memorializes its past, and understand how the past relates both to personal identity and collective identity formation. This article outlines how German programs might integrate historical inquiry into all levels of the curriculum and how language students learn to apply a cultural memory framework to the analysis of literature, film, and architecture from German‐speaking countries. Since linguistic and cultural competence are linked, it also examines how to advance both through historic content, how to sequence activities, and how to engage learners more deeply. Ultimately, this article concludes that students develop an interest in history and advance their linguistic and cultural literacy through scaffolded, interdisciplinary, and relevant instruction.