bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression
Authors: Kuo Yen-Shou , Zheng Ming-Yi , Huang Mo-Fan , Miao Chia-Cheng , Yang Li-Hao , Huang Tsai-Wang , Chou Yu-Ting 
Published: February 2020

AbstractChanges in expression patterns of serum carcinoembryonic antigen at initial diagnosis (CEAIn) and disease progression (CEAPd) in lung cancer patients under EGFR-tyrosine kinase inhibitors (TKI) treatment may reflect different tumor progression profiles. Of the 1736 lung cancer patients identified from the cancer registry group between 2011 to 2016, we selected 517 patients with advanced stage adenocarcinoma, data on EGFR mutation status and CEAIn, among whom were 288 patients with data on CEAPd, eligible for inclusion in the correlation analysis of clinical characteristics and survival. Multivariable analysis revealed that CEAIn expression was associated with poor progression-free survival in patients harboring mutant EGFR. Moreover, CEAIn and CEAPd were associated with the good and poor post-progression survival, respectively, in the EGFR-mutant group. Cell line experiments revealed that CEA expression and cancer dissemination can be affected by EGFR-TKI selection. EGFR-mutant patients, exhibiting high CEAIn (≥5 ng/mL) and low CEAPd (<5 ng/mL), showed a potential toward displaying new metastasis. Taken together, these findings support the conclusion that EGFR mutation status is a critical factor in determining prognostic potential of CEAIn and CEAPd in patients under EGFR-TKI treatment, and CEAIn and CEAPd are associated with distinct cancer progression profiles.
A Robust Image Registration Interface for Large Volume Brain Atlas
Authors: Ni Hong , Tan Chaozhen , Feng Zhao , Chen Shangbin , Zhang Zoutao , Li Wenwei , Guan Yue , Gong Hui , Luo Qingming , Li Anan 
Published: February 2020

AbstractAccurately mapping brain structures in three-dimensions is critical for an in-depth understanding of brain functions. Using the brain atlas as a hub, mapping detected datasets into a standard brain space enables efficient use of various datasets. However, because of the heterogeneous and nonuniform brain structure characteristics at the cellular level introduced by recently developed high-resolution whole-brain microscopy techniques, it is difficult to apply a single standard to robust registration of various large-volume datasets. In this study, we propose a robust Brain Spatial Mapping Interface (BrainsMapi) to address the registration of large-volume datasets by introducing extracted anatomically invariant regional features and a large-volume data transformation method. By performing validation on model data and biological images, BrainsMapi achieves accurate registration on intramodal, individual, and multimodality datasets and can also complete the registration of large-volume datasets (approximately 20 TB) within 1 day. In addition, it can register and integrate unregistered vectorized datasets into a common brain space. BrainsMapi will facilitate the comparison, reuse and integration of a variety of brain datasets.
“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells
Authors: Mitwasi Nicola , Feldmann Anja , Arndt Claudia , Koristka Stefanie , Berndt Nicole , Jureczek Justyna , Loureiro Liliana R. , Bergmann Ralf , Máthé Domokos , Hegedüs Nikolett , Kovács Tibor , Zhang Congcong , Oberoi Pranav , Jäger Elke , Seliger Barbara , Rössig Claudia , Temme Achim , Eitler Jiri , Tonn Torsten , Schmitz Marc , Hassel Jessica C. , Jäger Dirk , Wels Winfried S. , Bachmann Michael 
Published: February 2020

AbstractAntigen-specific redirection of immune effector cells with chimeric antigen receptors (CARs) demonstrated high therapeutic potential for targeting cancers of different origins. Beside CAR-T cells, natural killer (NK) cells represent promising alternative effectors that can be combined with CAR technology. Unlike T cells, primary NK cells and the NK cell line NK-92 can be applied as allogeneic off-the-shelf products with a reduced risk of toxicities. We previously established a modular universal CAR (UniCAR) platform which consists of UniCAR-expressing immune cells that cannot recognize target antigens directly but are redirected by a tumour-specific target module (TM). The TM contains an antigen-binding moiety fused to a peptide epitope which is recognized by the UniCAR molecule, thereby allowing an on/off switch of CAR activity, and facilitating flexible targeting of various tumour antigens depending on the presence and specificity of the TM. Here, we provide proof of concept that it is feasible to generate a universal off-the-shelf cellular therapeutic based on UniCAR NK-92 cells targeted to tumours expressing the disialoganglioside GD2 by GD2-specific TMs that are either based on an antibody-derived single-chain fragment variable (scFv) or an IgG4 backbone. Redirected UniCAR NK-92 cells induced specific killing of GD2-expressing cells in vitro and in vivo, associated with enhanced production of interferon-γ. Analysis of radiolabelled proteins demonstrated that the IgG4-based format increased the in vivo half-life of the TM markedly in comparison to the scFv-based molecule. In summary, UniCAR NK-92 cells represent a universal off-the-shelf platform that is highly effective and flexible, allowing the use of different TM formats for specific tumour targeting.
Posture-related ocular cyclotorsion during cataract surgery with an ocular registration system
Authors: Terauchi Ryo , Horiguchi Hiroshi , Ogawa Tomoichiro , Shiba Takuya , Tsuneoka Hiroshi , Nakano Tadashi 
Published: February 2020

AbstractOcular cyclotorsion when a patient changes from seated to supine position in cataract surgery and factors predicting the amount of cyclotorsion were investigated using VERION system. Variables analyzed were age, gender, preoperative visual acuity, axial length, laterality of eyes, operative duration, and the direction and degree of cyclotorsion. The mean cyclotorsion of 107 eyes of 93 cataract patients was 0.98 ± 4.85 degrees (median, 1 degree; range, -11 to 12 degrees), and the median absolute value was 4 degrees (mean, 4.05 ± 2.82 degrees; range, 0 to 12 degrees). Cyclotorsion was ≥3 degrees in 68 (63.6%) eyes. Excyclotorsion occurred more frequently than incyclotorsion (50.5% vs. 43.0%). There was no cyclotorsion in seven (6.5%). Multiple regression analysis showed that gender was a significant predictive factor for the absolute value of cyclotorsion (β = 1.06, P = 0.041); however, the other variables had no effect on cyclotorsion. The absolute value of cyclotorsion was significantly larger in female than in male patients [median, 4 degrees and 3 degrees, respectively; mean, 4.66 ± 3.02 degrees and 3.44 ± 2.52 degrees, respectively (P = 0.039)]. In conclusion, cataract patients had significant posture-related ocular cyclotorsion. The amount of cyclotorsion was larger for female than male patients.
Cataract surgery-related complications in patients with end-stage renal disease- a nationwide population-based study in Taiwan
Authors: Hsiao Ching-Hsing , Liang Fu-Wen , Ho Chung-Han , Chen Yi-Chen , Wang Jhi-Joung , Hsing Chung-Hsi , Wu Chia-Chun 
Published: February 2020

AbstractThis nationwide retrospective case-control study was aimed at elucidating the risk from cataract surgery in end-stage renal disease (ESRD) patients. Cataract surgery patients were identified using the diagnostic and procedural codes for International Classification of Diseases, 9th Revision, Clinical Modification from Taiwan’s National Health Insurance Research Database. ESRD patients were selected as cases, while propensity scores for age, sex, comorbidities and year-of-surgery-matched patients without chronic kidney disease constituted the controls. Patients who had undergone eye surgery within 3 years before cataract surgery were excluded. The main outcome measures were target cataract surgery-related complications within 3 months after surgery. A total of 352 cases and 1,760 controls were analysed. Patients with ESRD had a 5.06-fold (95% CI: 2.36–10.87; p < 0.001) risk of vitreous haemorrhage and a 2.74-fold (95% CI: 1.20–6.27; p = 0.017) risk of re-operation for dropped nucleus or vitreous complications. Non-diabetic ESRD patients had a 3.49-fold (95% CI: 1.36–8.91; p = 0.009) risk of corneal oedema. In conclusion, ESRD patients have a higher risk of vitreous haemorrhage, re-operation for dropped nucleus or vitreous complications and corneal oedema (non-diabetic patients) after cataract surgery. Pre-surgery corneal examination, surgery procedure and medication adjustment, closer and longer post-surgery follow-up may lower the risk and improve the visual outcome.
Genome-wide analysis of the hypoxia-related DNA methylation-driven genes in lung adenocarcinoma progression
Authors: Li Hongxia , Tong Li , Tao Hong , Liu Zhe 
Published: February 2020

Abstract
Lung adenocarcinoma (LUAD) is a common type of lung cancer with high incidence and poor prognosis. Hypoxia and DNA methylation play important regulatory roles in cancer progression. The purpose of the present study was to explore the relationship between hypoxia and DNA methylation, and to identify key genes for hypoxia-regulated LUAD progression. Hypoxia score (HS) was calculated using the GSVA algorithm. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and protein–protein interaction (PPI) analysis were performed using clusterProfile package, STRING database and Cytoscape software. Kaplan–Meier curves of overall survival (OS) and disease-free survival (DFS) were drawn using R software. Smoking status and cancer stages were significantly associated with LUAD hypoxia, and hypoxia is a poor prognostic factor for LUAD. Compared with HS-low group, 1803 aberrantly methylated DEGs were identified in HS-high group. KEGG analysis showed that the 1803 genes were enriched in the metabolic pathways associated with hypoxia stress, angiogenesis and cancer progression. FAM20C, MYLIP and COL7A1 were identified as the hypoxia-related key genes in LUAD progression, which were regulated by DNA methylation. Hypoxia in LUAD tumor cells led to changes in DNA methylation patterns. In-depth study of the relationship between hypoxia and DNA methylation is helpful to elucidate the mechanism of tumorigenesis, and provides new ideas for LUAD treatment.
Evaluating the Efficacy and Trend of Sinus Surgery
Authors: Petrovic Masa , Shamsian Arash , Hopp Martin L. , Vardanyan Narine 
Published: February 2020

Abstract
Introduction From April 2009 to December 2016, 661 consecutive patients undergoing sinus surgery completed a quality of life (QOL) questionnaire (SNOT-22) preoperatively and at 3, 6, and 12 months postoperatively.
Objective (1) To evaluate the long-term efficacy of sinus surgery using QOL instruments. (2) To determine the optimal evaluation time for surgical efficacy. (3) To determine if surgical results improve with yearly experience.
Methods The prospective study patients were split into two groups: Group A, those who completed the initial preoperative evaluation and all postoperative evaluations, and Group B, who completed the preoperative questionnaire and at least one but not all of the postoperative questionnaires. Group A included 93 patients. Group B included 240 patients at 3 months, 180 at 6 months, and 121 at 12 months postoperatively.
Results Group A efficacy reported at 3 months was 82.8%, 80.6% at 6 months, and 84.9% at 12 months postoperatively. Group B efficacy reported at 3 months was 71.3%, 78.3% at 6 months, and 84.3% at 12 months postoperatively. An 8-year trend analysis of year-to-year 12 months postoperative data illustrates a significant improvement with an analysis of variance (ANOVA) linear rate of 1.594 (p ≤0.12).
Conclusion The 8-year trend at 12 months postoperatively shows a positive improvement in surgical results. Patients undergoing sinus surgery at tertiary medical center showed 84.9% improvement in sinus disease symptoms by 12 months postoperatively. Long-term improvement analysis showed no difference between 6 months postoperatively and 12 months, signifying 6 months as an effective evaluation for surgical efficacy.
Objective Quantification of Opioid Usage After Thyroid Surgery
Authors: Agnew Andrew , Carroll Sean , Fornelli Rick , Schell Stephen , Steehler Kirk 
Published: February 2020

AbstractIntroduction It is well established that America is in the midst of an opioid crisis with 46 people dying every day from overdoses involving prescription opioids. In the last 2 years, multiple articles have been published indicating that the amount of opioid pain medication needed after discharge from thyroid and parathyroid surgery is low.Objective To objectively examine the amount of opioid pain medication required by patients in our practice after thyroid surgery.Methods Patients were given a standardized discharge prescription of 30 pills with a combination of 7.5 mg of hydrocodone and 325 mg of acetaminophen after thyroid surgery. They were asked to log the number of pills consumed per day and the level of pain per day using the Wong-Baker faces pain scale. We used in-office pill counts to ensure accuracy of the logs.Results While reaching a similar conclusion, the present study is the first to objectively examine the quantity of opioid pain medication consumed between postoperative discharge and office follow-up. Our study objectively demonstrates that 85% of patients consumed less than 75.0 morphine milligram equivalent (MME) after thyroid surgery using in-office pill counts.Conclusion Recent multimodality anesthesia research appears promising to dramatically reduce or even eliminate the need for opioid prescriptions upon postoperative discharge.
About an Intracranial Aneurysm Rupture During Delivery
Authors: Assoumane Ibrahim , Houari Loucif , Morsli Abdelhalim 
Published: February 2020

AbstractThe rupture of an intracranial aneurysm is rare during pregnancy and exceptional during delivery. When it occurs, the prognosis of two lives is engaged. We are reporting a case of a 41-year-old patient presenting with a subarachnoid hemorrhage during labor. After extraction of healthy baby through cesarian section, radiological investigations permitted to diagnose a ruptured right carotid-ophthalmic aneurysm. The patient benefited from a selective aneurysm’s exclusion by occlusion using Guglielmi detachable coils through an endovascular approach using catheterization. The immediate outcome was favorable.
Opto-chemo-mechanical transduction in photoresponsive gels elicits switchable self-trapped beams with remote interactions
Authors: Morim Derek R. , Meeks Amos , Shastri Ankita , Tran Andy , Shneidman Anna V. , Yashin Victor V. , Mahmood Fariha , Balazs Anna C. , Aizenberg Joanna , Saravanamuttu Kalaichelvi 
Published: February 2020

SignificanceSelf-trapped light beams hold potential for optical interconnects, applications in image transmission, rerouting light, logic gates for computing and, importantly, for the next-generation light-guiding-light signal processing, which envisions a circuitry-free and reconfigurable photonics powered by the dynamic interactions of self-trapped beams. In conventional nonlinear materials, however, self-trapping suffers from either the need for large incident beam powers and loss of beam interactions at large distances, or it is slow and irreversible. We show that rapidly and repeatably switchable self-trapped laser beams with remote communication capabilities can be elicited at exceptionally small intensities in a pliant, processable hydrogel functionalized with a chromophore. The ability to generate self-trapped beams with this unique set of properties offers unprecedented opportunities to develop light-guiding-light technologies.
Mismatches between demographic niches and geographic distributions are strongest in poorly dispersed and highly persistent plant species
Authors: Pagel Jörn , Treurnicht Martina , Bond William J. , Kraaij Tineke , Nottebrock Henning , Schutte-Vlok AnneLise , Tonnabel Jeanne , Esler Karen J. , Schurr Frank M. 
Published: February 2020

SignificanceForecasts of global change impacts on biodiversity often assume that the current geographical distributions of species match their ecological niches. Here we examine this assumption using an extensive dataset of large-scale variation in demographic rates that enables us to quantify demography-based ecological niches of 26 plant species. Contrasting these niches with the species’ geographic distributions reveals that niche–distribution mismatches can be large and depend on key life-history traits: poorly dispersed species are absent from suitable sites, and species with high persistence ability are present in sites that are currently unsuitable for them. Such niche–distribution mismatches need to be accounted for to improve forecasts of biodiversity dynamics under environmental change.
Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy
Authors: Chen Guojun , Chen Zhitong , Wen Di , Wang Zejun , Li Hongjun , Zeng Yi , Dotti Gianpietro , Wirz Richard E. , Gu Zhen 
Published: February 2020

Significance
Strategies to improve efficacy and reduce side effects of immune checkpoint blockade (ICB) therapy are clinically relevant. Here, we described a transdermal cold atmospheric plasma (CAP)-mediated ICB therapy. Local delivery of CAP through hollow-structured microneedles as microchannels promote the release of tumor-associated antigens by CAP. The subsequent T cell-mediated immune response can be augmented by the immune checkpoint inhibitors delivered via microneedles, resulting in enhanced local and systemic anticancer immunity. The synergism between CAP and ICB integrated with microneedles provides a platform technique for cancer treatment and other diseases in a minimally invasive manner.
Spacetimes with all Penrose limits diagonalisable*
Authors: Tod Paul 
Published: February 2020

Abstract
We consider the problem of finding all space-time metrics for which all plane-wave Penrose limits are diagonalisable plane waves. This requirement leads to a conformally invariant differential condition on the Weyl spinor which we analyse for different algebraic types in the Petrov–Pirani–Penrose classification. The only vacuum examples, apart from actual plane waves which are their own Penrose limit, are some of the nonrotating type D metrics, but some nonvacuum solutions are also identified. The condition requires the Weyl spinor, whenever it is nonzero, to be proportional to a valence-4 Killing spinor with a real function of proportionality.
Particle dance: particle physics in the dance studio
Authors: Nikolopoulos K , Pardalaki M 
Published: February 2020

Abstract
A workshop using dance to introduce particle physics concepts to young children is presented. The workshop is realised in the dance studio, the children assume complete ownership of the activity and dance becomes the means to express ideas. The embodiement of the physics concepts facilitates knowledge assimilation, while empowering the students with respect to science. Beyond the scientific and artistic benefits of this workshop, this approach aspires to overcome the barriers between art and science; and open new interdisciplinary horizons for the students.
Cloud shape of a molecular Bose–Einstein condensate in a disordered trap: a case study of the dirty boson problem
Authors: Nagler Benjamin , Radonjić Milan , Barbosa Sian , Koch Jennifer , Pelster Axel , Widera Artur 
Published: February 2020

Abstract
We investigate, both experimentally and theoretically, the static geometric properties of a harmonically trapped Bose–Einstein condensate of 6Li2 molecules in laser speckle potentials. Experimentally, we measure the in situ column density profiles and the corresponding transverse cloud widths over many laser speckle realizations. We compare the measured widths with a theory that is non-perturbative with respect to the disorder and includes quantum fluctuations. Importantly, for small disorder strengths we find quantitative agreement with the perturbative approach of Huang and Meng, which is based on Bogoliubov theory. For strong disorder our theory perfectly reproduces the geometric mean of the measured transverse widths. However, we also observe a systematic deviation of the individual measured widths from the theoretically predicted ones. In fact, the measured cloud aspect ratio monotonously decreases with increasing disorder strength, while the theory yields a constant ratio. We attribute this discrepancy to the utilized local density approximation, whose possible failure for strong disorder suggests a potential future improvement.
Continuous feedback on a quantum gas coupled to an optical cavity
Authors: Kroeger Katrin , Dogra Nishant , Rosa-Medina Rodrigo , Paluch Marcin , Ferri Francesco , Donner Tobias , Esslinger Tilman 
Published: February 2020

Abstract
We present an active feedback scheme acting continuously on the state of a quantum gas dispersively coupled to a high-finesse optical cavity. The quantum gas is subject to a transverse pump laser field inducing a self-organization phase transition, where the gas acquires a density modulation and photons are scattered into the resonator. Photons leaking from the cavity allow for a real-time and non-destructive readout of the system. We stabilize the mean intra-cavity photon number through a micro-processor controlled feedback architecture acting on the intensity of the transverse pump field. The feedback scheme can keep the mean intra-cavity photon number n
ph constant, in a range between n
ph = 0.17(4) and n
ph = 27.6(5), and for up to 4 s. Thus we can engage the stabilization in a regime where the system is very close to criticality as well as deep in the self-organized phase. The presented scheme allows us to approach the self-organization phase transition in a highly controlled manner and is a first step on the path towards the realization of many-body phases driven by tailored feedback mechanisms.
Small Target Recognition Using Dynamic Time Warping and Visual Attention
Authors: Zhang Xinpeng , Wu Jigang , Meng Min 
Published: February 2020

Abstract
Microaneurysm is a kind of small targets in color retinal image, and it is an essential work to recognize the small target for the early diagnosis of diabetic retinopathy. This paper proposes an efficient method to accurately recognize microaneurysm. A symmetric extended curvature Gabor wavelet is presented to generate candidate objects, where some novel features are extracted for classification. A kind of statistic features is generated to distinguish between microaneurysm and thin vessels, in terms of the shape similarity of cross-section profiles. Furthermore, the visual attention-based features are proposed to compute local contrast of small targets in complex background. Random undersampling with AdaBoost (RUSBoost) classifier is employed to discriminate true microaneurysm from an overwhelming amount of candidate objects. Experimental results demonstrate that the proposed method achieves significant sensitivity and accuracy on the public datasets, in comparison to the state-of-the-arts.