bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengetahuan Ibu Tentang Gizi Balita Dengan Status Gizi Balita Di Puskesmas Karangdadap Pekalongan
Authors: Andriyani Lulu Triska , Ersila Wahyu 
Published: December 2024

Balita usia 12-59 bulan rentan terhadap masalah gizi dan kesehatan. Hal ini dapat terjadi karena basal metabolic rate (BMR) lebih tinggi pada balita sehingga kebutuhan energinya lebih banyak dan dapat mempengaruhi status gizi stunting. Selain itu, pola asuh dan cara pemberian yang kurang tepat yang dilakukan oleh orang tua kepada anak salah satu hal yang meningkatkan risiko malnutrisi. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kondisi gizi balita dengan kesadaran ibu terhadap gizi balita. Penelitian yang dilaksanakan pada bulan November dan Desember 2023 di wilayah kerja Puskesmas Karangdadap Kabupaten Pekalongan ini merupakan penelitian deskriptif korelatif cross-sectional. Sampel penelitian berjumlah 139 responden atau balita usia 12-59 tahun. Variabel bebas yang diteliti adalah pengetahuan ibu, sedangkan variabel terikatnya adalah status gizi balita. Metode pengolahan dan analisis data yang digunakan dalam penelitian ini adalah uji peringkat Spearman. Berdasarkan hasil survei 85,7% ibu yang memiliki cukup informasi memiliki anak dengan perkembangan normal. Terdapat hubungan antara pengetahuan ibu tentang gizi balita dengan status gizi balita, dengan nilai koefisien korelasi sebesar 0,287, menunjukkan bahwa kekuatan hubungan cukup. Hasil uji statistik didapatkan nilai p = 0,001, dengan demikian nilai p lebih kecil dari alpha (0,05). Pengetahuan ibu berpengaruh terhadap status gizi balita, oleh karena itu peningkatan pemahaman ibu menjadi hal yang penting. Diharapkan tenaga kesehatan sebaiknya menggiatkan program penyuluhan tentang kebutuhan gizi balita dan memotivasi ibu untuk memberikan asupan nutrisi sesuai dengan kebutuhan balita serta meningkatkan frekuensi, keanekaragaman/memberdayakan nutrisi balita
Kata kunci : Pengetahuan ibu, status gizi, balita
PERANCANGAN SISTEM PAKAR DIAGNOSIS PENYAKIT IKAN AIR TAWAR MENGGUNAKAN METODE FORDWARD CHAINING BERBASIS WEB PADA UPTD BALAI BENIH IKAN DUKUPUNTANG KABUPATEN CIREBON
Authors: Priyatna Adjie , Jaya Suhana Minah , Imam Muhamad 
Published: December 2024

Sistem pakar adalah aplikasi berbasis komputer yang dirancang untuk menyelesaikan masalah layaknya seorang pakar. Penelitian ini bertujuan merancang dan membangun sistem pakar berbasis web untuk mempermudah diagnosis penyakit ikan di UPTD Balai Benih Ikan Dukupuntang, Kabupaten Cirebon. Saat ini, diagnosis penyakit ikan masih dilakukan secara manual, yaitu dengan pengamatan langsung dan uji laboratorium, yang memerlukan waktu lama dan kurang efisien. Hal ini sering menyebabkan kerugian besar, seperti kematian ikan akibat lambatnya deteksi dan penanganan penyakit.
Aplikasi sistem pakar berbasis web ini dirancang menggunakan bahasa pemrograman PHP, dengan Laravel 6 sebagai framework dan MySQL sebagai database. Metode pengembangan yang digunakan adalah Rapid Application Development (RAD), sementara data diperoleh melalui observasi, wawancara, dan studi literatur.
Aplikasi ini menyediakan fitur diagnosis berdasarkan gejala penyakit ikan dan memberikan solusi penanganan yang tepat. Dengan sistem ini, UPTD Balai Benih Ikan dapat mendeteksi penyakit secara lebih cepat dan akurat, sehingga mendukung efisiensi budidaya ikan air tawar.

Kata Kunci: Sistem Pakar, Website, Diagnosis, Penyakit, Ikan
Kinerja Pertumbuhan dan Kelulushidupan Benih Ikan Mas Sinyonya dengan Pakan Hormon Pertumbuhan Rekombinan
Authors: Fadhila Ridwan , Hermawan Dodi , Putra Achmad Noerkhaerin , Saifullah Saifullah 
Published: December 2024

Cyprinus carpio Linnaeus is a leading commodity for cultivation in Pandeglang Regency, Banten Province. One of the hormones that can stimulate fish growth is the recombinant Epinephelus lanceolatus growth hormone (rElGH) in artificial feed. The research aimed to determine the optimal dose of rElGH used in artificial feed on the growth and survival of Sinyonya. The common carp of Sinyonya initial weight of 2 g was reared in an aquarium with volume 72 L. The research design used was completely randomized design with four treatments, namely (A) control, (B) rElGH 3 mg/kg, (C) rElGH 6 mg/kg, and (D) rElGH 9 mg/kg and each treatment consisted of three replications. The results showed that the absolute weight of Sinyonya carp juvenile treated with treatment B produced the best biomass of 3.22±0.06 g, treatment C 3.14±0.05 g, treatment D 3.04±0 .08 g, and treatment A 2.62±0.06 g. The best survival rate in treatment B was 100%, treatment C 97.67%, treatment D 97.67%, and treatment A 93.33%. The feed consumed by treatment A 199.27 g, treatment B was 196.07 g, treatment C was 194.77 g, and treatment D was 195.33 g. The specific growth rate of treatment A 7.49%, treatment B 9.12%, treatment C 8.97%, and treatment D 8.69%. The feed conversion ratio for treatment B is 4,10%, treatment C 4.,16%, treatment D 4,32, and treatment A 5.,24% . The addition of rElGH to feed resulted in better growth and survival compared to the control treatment. Feeding with rElGH 3 mg/kg for 35 days was able to improve growth performance in the common carp Sinyonya.
Implementasi Strategi Coping Stress dalam Upaya Mengatasi Perilaku Bullying di Pondok Pesantren Al-Hikmah Gedanganak Ungaran
Authors: Priarni Rina , Rosidi Ayep , Listya Serani Dara 
Published: December 2024

This research aims to describe in detail how to implement stress coping strategies in an effort to overcome bullying behavior at the Al-Hikmah Gedang Islamic boarding school for children in Ungaran. This research uses a qualitative approach. Data collection was carried out through observation, in-depth interviews and documentation. Data analysis is carried out by giving meaning to the data that has been collected and from that meaning conclusions are drawn. The results of the research show that the implementation of stress coping strategies at the Al-Hikmah Gedanganak Islamic boarding school uses Emotional focused coping, including self-control, seeking social support, positive reinterpretation, acceptance and denial. Implementation activities for stress coping strategies begin with planning, implementation and evaluation using the CIPP evaluation model, namely Context, Input, Process, Product.
Identification of transcription factor-lipid droplet-related gene biomarkers for the prognosis of post-acute myocardial infarction-induced heart failure
Authors: Zhao Jianqiao , Guo Can , Cheng Mengyuan , Li Jie , Liu Yangyang , Wang Huahua , Shen Jianping 
Published: December 2024

IntroductionPatients with acute myocardial infarction (AMI) are at high risk of progressing to heart failure (HF). Recent research has shown that lipid droplet-related genes (LDRGs) play a crucial role in myocardial metabolism following MI, thereby influencing the progression to HF.MethodsWeighted gene co-expression network analysis (WGCNA) and differential expression gene analysis were used to screen a transcriptome dataset of whole blood cells from AMI patients with (AMI HF, n = 16) and without progression (AMI no-HF, n = 16). Functional enrichment analysis were performed to observe the involved function. Machine learning methods were used to screen the genes related to prognosis. Transcriptional factors (TF) were predicted by using relevant databases. ROC curves were drawn to evaluate the TF-LDRG pair in predicting HF in the validation dataset (n = 16) and the clinical trial (n = 13).ResultsThe 235 identified genes were primarily involved in pathways related to fatty acid and energy metabolism. 22 genes were screened out that they were strongly associated with prognosis. 35 corresponding transcription factors were predicted. The TF-LDRG pair, ABHD5-ARID3a, was demonstrated good predictive accuracy.DiscussionOur findings suggest that ABHD5-ARID3a have significant potential as predictive biomarkers for heart failure post-AMI which also provides a foundation for further exploration into the molecular mechanisms underlying the progression from AMI to HF.
Mild autonomous cortisol secretion leads to reduced volumetric BMD at lumbar spine in patients with primary aldosteronism
Authors: Mansour Nabeel , Bruedgam Denise , Heinrich Daniel , Dischinger Ulrich , Reisch Nicole , Völter Friederike , Stüfchen Isabel , Nowak Elisabeth , Zopp Stephanie , Vasileva Victoriya , Öcal Osman , Wildgruber Moritz , Seidensticker Max , Ricke Jens , Bidlingmaier Martin , Reincke Martin , Ribeiro de Oliveira Longo Schweizer Juínia 
Published: December 2024

ObjectivesGlucocorticoid cosecretion is more common in primary aldosteronism (PA) than previously thought. Chronic subtle cortisol excess in patients with mild autonomous cortisol secretion (MACS) negatively affects bone health. This study aimed to evaluate the impact of MACS on bone density and turnover markers in PA patients.MethodsPatients with PA and MACS (n = 50), confirmed by a 1-mg dexamethasone suppression test (DST) with a cortisol cutoff of ≥1.8 µg/dL without symptoms of overt Cushing, were compared to age- and sex-matched patients with PA without MACS (non-MACS, n = 50). Lumbar volumetric bone mineral density (vBMD) was extracted by a novel convolutional neural network (CNN)-based framework (SpineQ software v1.0) applied to routine CT data, incorporated into the diagnostic protocol for PA. Additionally, bone turnover markers—including osteocalcin, bone-specific alkaline phosphatase, N-terminal propeptide of type I collagen, and carboxy-terminal crosslinked telopeptide of type I collagen were evaluated between the groups.ResultsMedian cortisol after DST was 1.1 µg/dL (30.3 nmol/L) [IQR: 0.5 µg/dL (13.8 nmol/L)] in the non-MACS group and 2.5 µg/dL (69.0 nmol/L) [IQR: 1.4 µg/dL (38.5 nmol/L)] in the MACS group (p &lt; 0.001). Patients with MACS had significantly lower vBMD values compared to the non-MACS group (106.4 mg/cm³ vs. 116.6 mg/cm³, p = 0.038). Cortisol after DST negatively correlated with vBMD (Spearman’s r=−0.33, p=0.00042). No significant differences in bone turnover markers were found, and classifications based on visible lesions on CT or PA-lateralization via adrenal venous sampling did not reveal any significant differences in these markers (p &gt; 0.05 for all comparisons).ConclusionDespite non-significant differences in bone turnover markers between patients with PA with or without MACS, CT scans revealed significantly reduced vBMD in PA and MACS patients, indicating compromised bone health and vBMD significantly negatively correlated with cortisol post DST. Thus, opportunistic evaluation of vBMD in routine CT screenings could aid in the early detection of bone alterations in MACS and help mitigate potential long-term adverse effects on bone health.
Willingness of caregivers to have their daughters vaccinated against human papilloma virus and associated factors in Jimma Town, Southwest Ethiopia
Authors: Getachew Anebo , Anand Susan , Wodaynew Tilahun 
Published: December 2024

IntroductionHuman Papillomavirus (HPV) is a widespread sexually transmitted infection and a leading cause of cervical cancer. Although there is a significant HPV prevalence in Ethiopia, yet the uptake of the HPV vaccine remains low. This study aimed to assess the level of caregivers' willingness to vaccinate their daughters against the human papilloma virus and associated factors in Jimma town.MethodsA community-based cross-sectional study was conducted from June 1–30, 2023. A total of 471 study participants were selected using multi-stage sampling techniques. Data was collected using an interviewer-administered questionnaire. Binary and multiple logistic regression analyses were done to identify associated factors, and the adjusted odds ratio and 95% confidence interval were computed. A value p of &lt;0.05 was used to determine statistical significance.ResultsAbout 82.4% (95% CI: 79.0–86.0) of caregivers indicated a willingness to have their daughters vaccinated. Having college education or above (AOR:3.31, 95%CI:1.02–10.8), good knowledge of the HPV vaccine (AOR:2.25, 95%CI:1.05–4.85), good knowledge of sexually transmitted infections (STIs) (AOR:2.04, 95%CI: 1.09–3.82), good knowledge of cervical cancer (AOR:2.50, 95%CI:1.31–4.77) and a positive attitude towards the vaccine (AOR:4.03, 95%CI: 2.26–7.22), were associated with willingness.DiscussionThe majority of caregivers were willing to vaccinate their daughters against HPV. Caregivers who had higher education, good knowledge about the HPV vaccine, cervical cancer, and STIs, as well as positive attitudes towards the vaccine, were more likely to be willing to vaccinate. Efforts should be made to educate caregivers about the vaccine, cervical cancer, and STIs while promoting positive attitudes.
Older women's well-being during the COVID-19 pandemic: individual, community, and contextual factors
Authors: Banda Andrew , Hoffman Jaco , Roos Vera 
Published: December 2024

ObjectiveThis article aims to examine the influence of individual and community-contextual factors on the well-being of older women in Zambia during the COVID-19 pandemic, drawing on Bronfenbrenner's process-person-context-time model.MethodsSecondary data from the nationally representative 2021 SEIA were used, and bivariate and logistic regression analyses were performed to determine factors associated with the well-being of older women during the COVID-19 pandemic.ResultsOverall, 29% (613) of older women reported a decline in their well-being due to COVID-19. Older women in rural areas had lower odds of well-being [Adjusted Odds Ratio (AOR) 0.607, 95% 0455,0.809]. At the individual level, the well-being of older women during COVID-19 was associated with age (AOR O.362, 95% CI: 0.190,0.689) and being in paid work (AOR 0.737, 95% CI: 0.552,0.984). Despite education having a strong relationship with well-being, it had a weak effect on the well-being of older women during COVID-19. Community-level factors significantly associated with the well-being of older women amidst COVID-19 included attendance at public gatherings (e.g., church meetings, funerals) (AOR 1.465, 95% CI: 1.139,1.885) and perceived fear or anxiety due to COVID-19 (AOR 0.522, 95% CI: 0.392,0.696). A significant contextual-level factor was access to transport services during the pandemic (AOR 0.589, 95% CI: 0.390,0.890).ConclusionCOVID-19 has exposed the inadequacy of systems at different levels in meeting the needs of older women and promoting their well-being during emergencies. At the individual level, there is a need to support older women's livelihoods and educational opportunities. Despite limitations on social interactions during COVID-19, access to social gatherings and interactions supported older women's well-being. However, this was hampered by fear of contracting COVID-19 and the limitations in public transport that compromised their mobility to access services and visit people. A more extensive analysis of individual, community, and contextual factors should identify factors that support or compromise the well-being of older women during emergencies or shocks. There is a need for information about what livelihood strategies during and/or post shocks, or critical events such as COVID-19 could sustainably support older women's well-being.
Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome
Authors: de Laat-Kremers Romy , Huang Shengshi , ten Cate Hugo , Ninivaggi Marisa , de Laat Bas , Devreese Katrien 
Published: December 2024

IntroductionUnfolded Von Willebrand Factor (VWF) is increased in thrombotic pathologies such as myocardial infarction. Unfolded VWF mediates the binding of platelets without the need for collagen. β2-glycoprotein I (β2-GPI) is a natural inhibitor of the platelet-VWF interaction. The antiphospholipid syndrome (APS) is associated with thrombosis, with an important pathophysiological role of auto-antibodies directed against β2-GPI.Methods(Unfolded) VWF levels were studied in normal controls (n=93), APS patients (n=64), non-APS thrombosis patients (n=39) and non-APS auto-immune disease (AID) patients (n=49.ResultsUnfolded VWF levels were respectively, 53%, 50% and 36% higher in APS patients, non-APS thrombosis patients and AID patients, compared to normal controls (p&lt;0.0001). Unfolded VWF levels above the 90th percentile in normal controls were associated with an odds of APS (OR: 8.51; CI:3.26 - 22.2; p&lt;0.001), compared to ORs of non-APS thrombosis (OR:5.87; CI:2.07 - 16.7, p=0.001) and AID (OR:3.71; CI:1.40 – 9.87; p=0.009). DiscussionWe found that APS patients have high levels of unfolded VWF in their circulation. In APS, auto-antibodies against-β2-GPI may interfere with the β2-GPI-mediated inhibition of VWF-platelet interaction. Therefore, the higher unfolded VWF levels in APS could in part explain the association of APS and thrombotic complications.
The specific medications for pulmonary arterial hypertension at functional class III to IV: a systematic review and meta-analysis
Authors: Li Qiang , Kuang Hongyu , Yi Qijian , Du Huaan 
Published: December 2024

PurposeTo systematically evaluate the clinical efficacy and safety of targeted drugs in patients with pulmonary arterial hypertension (PAH) with cardiac function grades III–IV, and conduct a meta-analysis.MethodsTwo researchers independently searched the PubMed, EMBASE, and Cochrane Library databases for relevant studies, with the search period extending from the establishment of the databases to March 2024. Meta-analysis was performed using statistical software Review Manager 5.4. Heterogeneity among studies was analyzed using either a random-effects model or a fixed-effects model. When the I2 value was &lt; 50%, indicating good homogeneity, the fixed-effects model was adopted; otherwise, the random-effects model was used. For continuous variables, the 6-minute walk distance (6MWD) was expressed as the mean difference (MD), while hemodynamic parameters were represented by the standard mean difference (SMD). For categorical variables, the odds ratio (OR) was used. The confidence interval (CI) was set at 95%, and a p &lt; 0.05 was considered statistically significant.ResultsTen randomized controlled trials (RCTs) involving 553 patients with PAH and cardiac function grades III-IV were ultimately included. Three RCTs targeted the endothelin pathway, five targeted the prostacyclin pathway, and two assessed the effects of combination therapy. Meta-analysis and subgroup analysis revealed that short-term monotherapy with bosentan significantly improved 6MWD by ~53.67 m (95% CI: [43.57, 63.77] meters, p &lt; 0.0001) in patients with FC III-IV PAH. Additionally, prostacyclin analogs increased 6MWD by approximately 25.02 meters (95% CI: [19.22, 30.81] meters, p &lt; 0.0001) in this patient population. Further hemodynamic assessments demonstrated that both bosentan monotherapy and prostacyclin analog therapy significantly reduced pulmonary vascular resistance, with SMDs of −1.07 (95% CI [-2.08, −0.06], p = 0.04) and −1.26 (95% CI = [−2.21, −0.32], p = 0.009), respectively. Analysis of the clinical efficacy of combination therapy in PAH patients revealed that while it did not significantly improve 6MWD, cardiac function improved in ~59.1% of patients (95% CI=[38.5%, 79.6%]). Safety analysis indicated that combination targeted therapy did not significantly increase the incidence of severe adverse events in PAH patients.ConclusionMonotherapy with targeted drugs is safe and effective for patients with PAH and cardiac function grades III-IV. Combination therapy can significantly improve cardiac dysfunction in these patients without significantly increasing the risk of severe adverse events. Therefore, bosentan and prostacyclin analogs are both safe and effective options for patients with PAH and cardiac function grades III-IV. However, early combination therapy may have added clinical value in improving exercise tolerance, cardiac function, and cardiovascular remodeling in this patient population.
Association between metabolic score for visceral fat and obstructive sleep apnea: a cross-sectional study
Authors: Xu Xue , Xu Jing , Zhang Mengye 
Published: December 2024

BackgroundPrevious studies have established a connection between obesity and obstructive sleep apnea (OSA), novel surrogate markers of adipose accumulation may serve as more critical and reliable factors for consideration. Consequently, this study aims to explore and elucidate the correlation between metabolic score for visceral fat (METS-VF) and OSA.MethodsIn this cross-sectional study, the data from the National Health and Nutrition Examination Survey (NHANES) during the period from 2013 to 2020 were adopted. Through multivariate logistic regression, restricted cubic spline regression (RCS), subgroup analyses and sensitivity analyses, the correlation between METS-VF and OSA was explored.ResultsAmong 8,284 subjects, 4,176 of them were categorized as having OSA. It was observed that the quartile range of METS-VF increased, with a notable rise in the prevalence of OSA (32.8% vs. 49.8% vs. 56.9% vs. 62.1%, p &lt; 0.001). Logistic regression analyses showed a significant positive correlation between METS-VF and the risk of having OSA, even after accounting for potential confounders (OR = 2.436, 95% CI: 2.065, 2.874). Subgroup analyses further revealed a stronger correlation between OSA and METS-VF among subjects who were female, younger, and Mexican Americans. RCS regression identified a positive linear correlation, without threshold effects. Sensitivity analyses with stop breathing (OR = 2.283, 95%CI: 1.169, 3.070) or snoring (OR = 2.716, 95%CI: 2.273, 3.246) as outcomes reaffirmed the positive correlation with METS-VF.ConclusionElevated METS-VF demonstrated a linear correlation with the increased incidence of OSA, suggesting the potential utility as a predictive index for OSA.