bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imatinib overrides taxane resistance by selective inhibition of novel CLIP1 variant obstructing the microtubule pore
Authors: Kita Katsuhiro , Thakkar Prashant V. , Galletti Giuseppe , Madhukar Neel , Navarro Elena Vila , Barasoain Isabel , Goodson Holly V. , Sackett Dan , Díaz José Fernando , Elemento Olivier , Shah Manish A. , Giannakakou Paraskevi 
Published: November 2019

AbstractDespite its widespread use, the majority of patients with gastric cancer (GC) will not respond to taxane chemotherapy due to resistance mechanisms. Here, we report the discovery of a novel truncated variant of the microtubule plus-end binding protein (+TIP) CLIP-170, hereafter CLIP-170S, whose expression is enriched in taxane resistant cell lines and patients with GC. To establish causation, we knocked-down (KD) CLIP-170S which completely reversed taxane resistance. Mass-spec proteomics and 5’-RACE further showed that CLIP-170S lacked the first 150 amino acids, including the Cap-Gly motif required for microtubule (MT) plus-end localization. Mechanistically, we show that CLIP-170S was mislocalized from the MT plus-end to the MT lattice obstructing the MT pore surface site required for taxane entry into the MT lumen. Computational analysis of RNA-seq data from taxane-sensitive and resistant GC cell lines, predicted imatinib as the top candidate drug to overcome drug resistance. Imatinib treatment completely reversed taxane resistance, as predicted, and did so unexpectedly by selective depletion of CLIP-170S. Importantly, CLIP170S was found to be highly prevalent in tumor biopsies from patients with GC. Taken together, these data identify CLIP-170S as a novel, clinically prevalent +TIP variant that obstructs the MT pore and confers taxane resistance. The discovery of this previously unrecognized variant together with the computational discovery of Imatinib as a selective CLIP-170S inhibitor, implicate the MT pore in clinical taxane resistance and provide new therapeutic opportunities for treatment of GC and beyond.
Regulation of nerve growth and patterning by cell surface protein disulphide isomerase
Authors: Cook Geoffrey M.W. , Sousa Catia , Schaeffer Julia , Wiles Katherine , Jareonsettasin Prem , Kalyanasundaram Asanish , Walder Eleanor , Casper Catharina , Patel Serena , Chua Pei Wei , Riboni-Verri Gioia , Raza Mansoor , Swaddiwudhipong Nol , Hui Andrew , Abdullah Ameer , Wajed Saj , Keynes Roger J. 
Published: November 2019

AbstractContact repulsion of growing axons is an essential mechanism for spinal nerve patterning. In birds and mammals the embryonic somites generate a linear series of impenetrable barriers, forcing axon growth cones to traverse one half of each somite as they extend towards their body targets. This study shows that protein disulphide isomerase provides a key component of these barriers, mediating contact repulsion at the cell surface in half-somites. Repulsion is reduced bothin vivoandin vitroby a range of methods that inhibit enzyme activity. The activity is critical in initiating a nitric oxide/S-nitrosylation-dependent signal transduction pathway that regulates the growth cone cytoskeleton. Rat forebrain grey matter extracts contain a similar activity, and the enzyme is expressed at the surface of cultured human astrocytic cells and rat cortical astrocytes. We suggest this system is co-opted in the brain to counteract and regulate aberrant nerve terminal growth.
A big-data approach to understanding metabolic rate and response to obesity in laboratory mice
Authors: Corrigan June K. , Ramachandran Deepti , He Yuchen , Palmer Colin , Jurczak Michael J. , Li Bingshan , Friedline Randall H. , Kim Jason K. , Ramsey Jon J. , Lantier Louise , McGuinness Owen P. , Banks Alexander S. ,   Mouse Metabolic Phenotyping Center Energy Balance Working Group
Published: November 2019

AbstractMaintaining a healthy body weight requires an exquisite balance between energy intake and energy expenditure. In humans and in laboratory mice these factors are experimentally measured by powerful and sensitive indirect calorimetry devices. To understand the genetic and environmental factors that contribute to the regulation of body weight, an important first step is to establish the normal range of metabolic values and primary sources contributing to variability in results. Here we examine indirect calorimetry results from two experimental mouse projects, the Mouse Metabolic Phenotyping Centers and International Mouse Phenotyping Consortium to develop insights into large-scale trends in mammalian metabolism. Analysis of nearly 10,000 wildtype mice revealed that the largest experimental variances are consequences of institutional site. This institutional effect on variation eclipsed those of housing temperature, body mass, locomotor activity, sex, or season. We do not find support for the claim that female mice have greater metabolic variation than male mice. An analysis of these factors shows a normal distribution for energy expenditure in the phenotypic analysis of 2,246 knockout strains and establishes a reference for the magnitude of metabolic changes. Using this framework, we examine knockout strains with known metabolic phenotypes. We compare these effects with common environmental challenges including age, and exercise. We further examine the distribution of metabolic phenotypes exhibited by knockout strains of genes corresponding to GWAS obesity susceptibility loci. Based on these findings, we provide suggestions for how best to design and conduct energy balance experiments in rodents, as well as how to analyze and report data from these studies. These recommendations will move us closer to the goal of a centralized physiological repository to foster transparency, rigor and reproducibility in metabolic physiology experimentation.
Accounting and accountability in the Anthropocene
Authors: Bebbington Jan , Österblom Henrik , Crona Beatrice , Jouffray Jean-Baptiste , Larrinaga Carlos , Russell Shona , Scholtens Bert 
Published: November 2019

Purpose
The purpose of this paper is to interrogate the nature and relevance of debates around the existence of, and ramifications arising from, the Anthropocene for accounting scholarship.

Design/methodology/approach
The paper’s aim is achieved through an in-depth analysis of the Anthropocene, paying attention to cross-disciplinary contributions, interpretations and contestations. Possible points of connection between the Anthropocene and accounting scholarship are then proposed and illuminated through a case study drawn from the seafood sector.

Findings
This paper develops findings in two areas. First, possible pathways for further development of how accounting scholarship might evolve by the provocation that thinking about the Anthropocene is outlined. Second, and through engagement with the case study, the authors highlight that the concept of stewardship may re-emerge in discussions about accountability in the Anthropocene.

Research limitations/implications
The paper argues that accounting scholarship focused on social, environmental and sustainability concerns may be further developed by engagement with Anthropocene debates.

Practical implications
While accounting practice might have to change to deal with Anthropocene induced effects, this paper focuses on implications for accounting scholarship.

Social implications
Human well-being is likely to be impacted if environmental impacts accelerate. In addition, an Anthropocene framing alters the understanding of nature–human interactions and how this affects accounting thought.

Originality/value
This is the first paper in accounting to seek to establish connections between accounting, accountability and the Anthropocene.
Does a “soft” board gender quotas policy work?
Authors: Conde-Ruiz José Ignacio , García Manu , Yáñez Manuel 
Published: November 2019

Purpose
The purpose of this paper is to analyze the functioning of a non-sanction “soft” gender quota policy structure (a simple recommendation), using the case of Spain. In the first part of the paper, the authors have reported the dismal improvement regarding the increase of female percentage presence in the companies’ boards of members.

Design/methodology/approach
The authors provide a detailed sectorial analysis and a classification of board members by type (executive, proprietary, independent and other external). In the second part, the authors exploit the fact that since 2013, the stock-listed companies are legally obliged to respond to a series of questions on gender diversity issues in their annual reports. Using this requirement, the authors perform an analysis using text processing techniques. The authors find that “self-plagiarism” is common in the responses – i.e. they copy responses from previous years – as well as “plagiarism” – i.e. they copy responses from other companies in previous years.

Findings
The insufficient progress in respect to the goals of the Law of Equality of 2007 (enacted by Spanish authorities) and the lack of interest that can be inferred from the companies’ responses included in their annual reports lead the authors to consider the necessity of changing the law on the corporate policies gender quotas in Spain.

Originality/value
It is the first study that realizes this type of analysis for Spain.
Polarization independent bandstop frequency selective surface for X-band application
Authors: D. Kanchana , Sankararajan Radha , B.S. Sreeja , E. Manikandan 
Published: November 2019

Purpose
A novel low profile frequency selective surface (FSS) with a band-stop response at 10 GHz is demonstrated. The purpose of this designed FSS structure is to reject the X-band (8-12 GHz) for the application of shielding. The proposed FSS structure having the unit cell dimension of 8 × 8 mm2, the miniaturization of the FSS unit cell in terms of λ0 is 0.266 λ0 × 0.266 λ0, where λ0 is free space wavelength. The designed FSS provides 4 GHz bandwidth with insertion loss of 15 dB. The transverse electric (TE) and transverse magnetic (TM) modes of the proposed design are same because of polarization independent characteristics and hold the angularly stable frequency response for both TE and TM mode polarization. Both the simulation and measurement results are in good agreement to each other.

Design/methodology/approach
The proposed FSS design contains square-shaped PEC material, which is placed on the substrate and the shape of the circle and rectangle is etched over the PEC material. The PEC material of the patch dimension is 0.0175 mm. The substrate used for the proposed design is FR4 lossy with the thickness of 0.8 mm and permittivity εr = 4.3 having a loss tangent of 0.02.

Findings
To find a new design and miniaturized FSS structure is discussed.

Originality/value
100%
Numerical investigation of passive cavitation control using a slot on a three-dimensional hydrofoil
Authors: Liu Cheng , Yan Qingdong , Wood Houston G. 
Published: November 2019

Purpose
The purpose of this paper is to study the mechanism and suppression of instabilities induced by cavitating flow around a three-dimensional hydrofoil with a particular focus on cavitation control with a slot.

Design/methodology/approach
The transient cavitating flow around a Clark-Y hydrofoil was investigated using a transport-equation-based cavitation model and the stress-blended eddy simulation model was used to capture the flow turbulence. A homogeneous Rayleigh–Plesset cavitation model was used to model the transient cavitation process and the results were validated with test data. A slot was applied to the hydrofoil to suppress cavitation instabilities, and various slot widths and exit locations were applied to the blade and the cavitation behavior, as well as drag/lift forces, were simulated and compared to investigate the effects of slot geometries on cavitation suppression.

Findings
The large eddy simulation based turbulence model was able to capture the interactions between the cavitation and turbulence. Moreover, the simulation revealed that the re-entrant jet was responsible for the periodic shedding of cavities. The results indicated that a slot was able to mitigate or even suppress cavitation-induced instabilities. A jet flow was generated at the slot exit and disturbed the re-entrant jet. If the slot geometry was properly designed, the jet could block the re-entrant jet and suppress the unsteady cavitation behavior.

Originality/value
This study provides unique insights into the complicated transient cavitation flows around a three-dimensional hydrofoil and introduces an effective passive cavitation control technique useful to researchers and engineers in the areas of fluid dynamics and turbomachinery.
Are lesson study participants sharing their professional knowledge?
Authors: Whitney Stephanie R. 
Published: November 2019

PurposeResearch and practice are often seen as separate entities, however, the notion of teacher as researcher situates the act of teaching as research (Watanabe, 2018). Educators in Japan identify as researchers with contributions to make to the field. Lesson study is one vehicle for their research. The purpose of this paper is to understand whether educators outside Japan are sharing their work resulting from lesson study to impact the field beyond their local context.Design/methodology/approachDatabases were searched to find cases (n=45) of lesson study in K-12 mathematics classrooms in the USA. Descriptions of how lesson study was implemented were coded to determine whether sharing of findings was a part of the lesson study cycle and, if so, to identify the mechanisms for sharing.FindingsIn 12 of the 45 cases, there was evidence that the lesson study team shared their findings beyond the team. The modes of sharing included inviting people to the research lesson, distributing the research lesson, presenting at conferences or writing articles.Research limitations/implicationsThe cases are limited to published lesson study projects. The end of the lesson study cycle for teams not sharing was not evaluated.Practical implicationsWays to make sharing results more accessible are discussed.Originality/valueThe originality of this paper is in that it evaluates a large number of documented cases of lesson study to understand if and how teachers are making their professional knowledge gained through lesson study public.
Does inward remittance lead to export performance in South Asian countries?
Authors: Jena Nihar Ranjan , Sethi Narayan 
Published: November 2019

PurposeThe purpose of this paper is to empirically investigate whether inward remittance leads to export performance in selected South Asian economies over the time period of 1993–2017.Design/methodology/approachThe stationarity of the variables is checked by Levin, Lin and Chut, Breitungt-stat., Im, Pesaran and ShinW-stat., ADF–Fisher and Philips–Perron–Fisher panel unit root tests. Panel Granger Causality is used to verify the short-run causality. Pedroni’s, Kao’s and Johansen–Fisher panel cointegration approaches are employed to examine the long-run relationship among the variables. Panel VECM is used to confirm the existence of a long-run relationship among the variables.FindingsPanels FMOLS and DOLS show that remittance inflows have negatively impacted the export performance of the selected South Asian countries during the study period. Granger Causality and VECM test confirm the existence of short-run and long-run relationship among the variables. The authors conclude that inward remittance is affecting export performance negatively during the study period. Furthermore, inward remittances occupy a major source of development finance for selected South Asian countries.Originality/valueThe study uses a dynamic macroeconomic modeling framework to assess the inward remittance on export performance in South Asian countries. Taking into account the diversity of the level of growth experienced by the five countries in the Asian region, the study uses an appropriate regression technique, i.e. panel dynamic OLS whose results are robust. As exports are a proven way to further economic growth, this study fills a vital gap in the literature by ascertaining the degree of impact of remittances in influencing outbound exports from the South Asian region.
Capital structure dynamics of Indian corporates
Authors: Rani Neelam , Yadav Surendra S. , Tripathy Naliniprava 
Published: November 2019

PurposeThe purpose of this paper is to examine the capital structure determinants and speed of adjustment (SOA) toward the target capital structure of firms.Design/methodology/approachThe study has used the generalized method of moments (GMM) model and two-stage least squares (TSLS) to the panel data of 3,310 Indian firms, from January 2000 to March 2018, to determine the adjustment speed toward target capital structure. Further, the study employed a fully modified ordinary least square technique to shed light on the dynamic nature of the adjustment process.FindingsThe results of the GMM estimations indicate that Indian firms are adjusting their capital structure toward the target rate of 10.38 percent per year. Similarly, the findings of TSLS estimate specify a SOA of 15.49 percent per year. The low adjustment speed suggests the prevalence of higher adjustment costs of Indian firms.Research limitations/implicationsFuture research can be undertaken by including certain macroeconomic factors such as GDP, inflation and the interest rate, which also affect the SOA since firms are pretentious by market conditions while designing capital structure for firms.Practical implicationsIn the current financial and regulatory set-up when there are frequent perturbations in the capital market, the study will be valuable for regulators, firms and academicians. The work would enable the concerned stakeholders to manage their scare resources and capital effectively by a better way to make informed decisions. It will facilitate managers of young companies to identify and regulate the factors that are more pertinent for them to make flexible financial decisions concerning the capital structure.Originality/valueThe study amplifies on previous studies and provides new insights on the speed of the adjustment process of Indian firms, helping to modify and refine their capital structures toward the optimum capital structure. This will not only enhance the financial flexibility in the capital structure of Indian corporates but also be of great value to the policymakers and other stakeholders.
The efficiency of wages, profit sharing, and stock
Authors: Weltmann Dan 
Published: November 2019

PurposeThe purpose of this paper is to examine which forms of compensation are more efficient at affecting employee attitudes, thus extending efficiency wage theory from wage-based compensation to profit sharing and stock-based compensation.Design/methodology/approachThree models of efficiency wage theory were tested: shirking, turnover and gift exchange. The effects of those three modes of compensation (wages, profit sharing and stock) were contrasted for the three models of efficiency wage theory.FindingsThe findings were that raising wages is the most efficient form of compensation in the turnover and shirking models, while in the gift exchange model profit sharing and stock-based compensation may function like efficiency wages.Originality/valueThis is the first study of this particular issue.
Turning employees into owners
Authors: Case John , Quarrey Michael 
Published: November 2019

Purpose
The purpose of this paper is to review and analyze policies where employee share ownership might be relevant to the inequality debate in the USA.

Design/methodology/approach
Description and analysis of policy alternatives designed to increase the prevalence of employee ownership in the USA economy.

Findings
Since 1974, Congress has passed many provisions to encourage employee ownership, all with widespread bipartisan support. Additional policies would have an even greater impact. Congress could “level the playing field” for corporate divestitures and sales of companies by private equity firms; create Employee Ownership Investment Corporations, modeled after Small Business Investment Corporations, to provide capital for sales to employees; and create an Employee Equity Loan Program to guarantee loans for employee-ownership transactions. Such measures would have no budgetary impact. It could also create tax incentives to encourage corporate and private-equity sales to employees and establish regulations to ensure that employee-owned companies are eligible for the full benefit of recent opportunity zone legislation. Legislation could also encourage publicly traded companies to offer stock to employees at a discount and require companies that receive various forms of special treatment from the government to establish employee stock-ownership programs.

Originality/value
The academic journal literature has virtually no policy analyses on employee share ownership.
Skin in the game – investor behavior in asset pricing, the Indian context
Authors: Gupta Saurabh , Bhaduri Saumitra N. 
Published: November 2019

Purpose
The purpose of this paper is to investigate investor behavior under two broad categories, market-wide sentiment and herding.

Design/methodology/approach
Using a dynamic factor model, that extracts distinct latent factors representing fluctuations in asset returns due to changes in fundamentals as well as investors’ sentiments, the paper investigates the impact of investor behavior on asset pricing.

Findings
Consistent with the literature, the results suggest that the behavioral factors play a significant role in explaining variation in the asset prices. However, the degree of influence depends on the nature of the stocks or portfolios. The findings conform to the hypothesis that behavioral factors play a more important role in explaining the price movements of high and medium valued stocks than those of smaller valued stocks. Further, the behavioral factors also exhibit high auto-correlation, depicting the pervasive nature of such factors, and proving that information cascades and other behavioral mechanisms propagate over a period of time leading to bubbles and market crashes. Finally, since herding is often associated with market volatility, the authors test the hypothesis using two measures of volatility and the result shows positive significant associations between them as suggested in the literature.

Originality/value
The paper presents a dynamic factor model to study the impact of investor behavior on asset returns using a conventional three factors model with behavioral factors. A factor model is proposed to extract distinct latent factors representing fluctuations in asset returns due to changes in fundamentals as well as investors’ sentiments. The study investigates investor behavior under two broad categories, market-wide sentiment and herding. Consistent with the literature, the results suggest that the behavioral factors play a significant role in explaining variation in the asset prices. However, the degree of influence depends on the nature of the stocks or portfolios. The findings conform to the hypothesis that behavioral factors play a more important role in explaining the price movements of high and medium valued stocks than those of smaller valued stocks. Further, the behavioral factors also exhibit high auto-correlation, depicting the pervasive nature of such factors, and proving that information cascades and other behavioral mechanisms propagate over a period of time leading to bubbles and market crashes.