bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOI-222: a single-transit TESS candidate revealed to be a 34-d eclipsing binary with CORALIE, EulerCam, and NGTS
Authors: Lendl Monika , Bouchy François , Gill Samuel , Nielsen Louise D , Turner Oliver , Stassun Keivan , Acton Jack S , Anderson David R , Armstrong David J , Bayliss Daniel , Belardi Claudia , Bryant Edward M , Burleigh Matthew R , Chaushev Alexander , Casewell Sarah L , Cooke Benjamin F , Eigmüller Philipp , Gillen Edward , Goad Michael R , Günther Maximilian N , Hagelberg Janis , Jenkins James S , Louden Tom , Marmier Maxime , McCormac James , Moyano Maximiliano , Pollacco Don , Raynard Liam , Tilbrook Rosanna H , Udry Stéphane , Vines Jose I , West Richard G , Wheatley Peter J , Ricker George , Vanderspek Roland , Latham David W , Seager Sara , Winn Josh , Jenkins Jon M , Addison Brett , Briceño César , Brahm Rafael , Caldwell Douglas A , Doty John , Espinoza Néstor , Goeke Bob , Henning Thomas , Jordán Andrés , Krishnamurthy Akshata , Law Nicholas , Morris Robert , Okumura Jack , Mann Andrew W , Rodriguez Joseph E , Sarkis Paula , Schlieder Joshua , Twicken Joseph D , Villanueva Steven , Wittenmyer Robert A , Wright Duncan J , Ziegler Carl 
Published: December 2019

ABSTRACT
We report the period, eccentricity, and mass determination for the Transiting Exoplanet Survey Satellite (TESS) single-transit event candidate TOI-222, which displayed a single 3000 ppm transit in the TESS 2-min cadence data from Sector 2. We determine the orbital period via radial velocity measurements (P = 33.9 d), which allowed for ground-based photometric detection of two subsequent transits. Our data show that the companion to TOI-222 is a low-mass star, with a radius of $0.18_{-0.10}^{+0.39}$ R⊙ and a mass of 0.23 ± 0.01 M⊙. This discovery showcases the ability to efficiently discover long-period systems from TESS single-transit events using a combination of radial velocity monitoring coupled with high-precision ground-based photometry.
Long secondary periods in luminous red giant variables
Authors: Takayama Masaki , Ita Yoshifusa 
Published: December 2019

ABSTRACT
The origin of long secondary periods (LSPs) in red giant variables is unknown. We investigate whether stellar pulsations in red giants can explain the properties of the LSP variability. VIJHKs light curves obtained by OGLE and the IRSF/SIRIUS survey in the Small Magellanic Cloud are examined. The sample of oxygen-rich LSP stars shows evidence of a phase lag between the light curves of optical and near-IR band. The change in radius contributes to the bolometric change roughly half as much as the change in temperature, implying that the change in effective temperature plays an important role in the luminosity change associated with the LSPs. We have created numerical models based on the spherical harmonics to calculate the light amplitudes of dipole mode variability and have found that the models can roughly reproduce the amplitude–amplitude relations (e.g. (ΔI, ΔH)). The LSP variability can be reproduced by the dipole mode oscillations with temperature amplitude of ≲100 and ≲150 K for oxygen-rich stars and most carbon stars, respectively. Radial pulsation models are also examined and can reproduce the observed colour change of the LSPs. However, there is still an inconsistency in length between the LSP and periods of radial fundamental mode. On the other hand, theoretical period–luminosity relations of the dipole mode corresponding to so-called oscillatory convective mode were roughly consistent with observation. Hence, our result suggests that the observations can be consistent with stellar pulsations corresponding to oscillatory convective modes.
Local RR Lyrae stars: native and alien
Authors: Zinn R , Chen X , Layden A C , Casetti-Dinescu D I 
Published: December 2019

ABSTRACT
Measurements of [Fe/H] and radial velocity are presented for 89 RR Lyrae (RRL) candidates within 6 kpc of the Sun. After the removal of two suspected non-RRLs, these stars were added to an existing data base, which yielded 464 RRLs with [Fe/H] on a homogeneous scale. Using data from the Gaia satellite (Data Release 2), we calculated the positions and space velocities for this sample. These data confirm the existence of a thin disc of RRL with [α/Fe] ∼ solar. The majority of the halo RRLs with large total energies have near-zero angular momenta about the Z-axis. Kinematically, these stars closely resemble the Gaia-Sausage/Gaia-Enceladus stars that others have proposed are debris from the merger of a large galaxy with the Milky Way. The metallicity and period distributions of the RRLs and their positions in the period–amplitude diagram suggest that this disrupted galaxy was as massive as the Large Magellanic Cloud and possibly greater.
NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae
Authors: Stefanik Natalia , Bizan Jakub , Wilkens Alwine , Tarnawska-Glatt Katarzyna , Goto-Yamada Shino , Strzałka Kazimierz , Nishimura Mikio , Hara-Nishimura Ikuko , Yamada Kenji 
Published: December 2019

Abstract
Brassicaceae and closely related species develop unique endoplasmic reticulum (ER)-derived structures called ER bodies, which accumulate β-glucosidases/myrosinases that are involved in chemical defense. There are two different types of ER bodies: ER bodies constitutively present in seedlings (cER bodies) and ER bodies in rosette leaves induced by treatment with the wounding hormone jasmonate (JA) (iER bodies). Here, we show that At-α whole-genome duplication (WGD) generated the paralogous genes NAI2 and TSA1, which consequently drive differentiation of cER bodies and iER bodies in Brassicaceae plants. In Arabidopsis, NAI2 is expressed in seedlings where cER bodies are formed, whereas TSA1 is expressed in JA-treated leaves where iER bodies are formed. We found that the expression of NAI2 in seedlings and the JA inducibility of TSA1 are conserved across other Brassicaceae plants. The accumulation of NAI2 transcripts in Arabidopsis seedlings is dependent on the transcription factor NAI1, whereas the JA induction of TSA1 in rosette leaves is dependent on MYC2, MYC3 and MYC4. We discovered regions of microsynteny, including the NAI2/TSA1 genes, but the promoter regions are differentiated between TSA1 and NAI2 genes in Brassicaceae. This suggests that the divergence of function between NAI2 and TSA1 occurred immediately after WGD in ancestral Brassicaceae plants to differentiate the formation of iER and cER bodies. Our findings indicate that At-α WGD enabled diversification of defense strategies, which may have contributed to the massive diversification of Brassicaceae plants.
Pathomechanics Underlying Femoroacetabular Impingement Syndrome: Theoretical Framework to Inform Clinical Practice
Authors: Cannon Jordan , Weber Alexander E , Park Seol , Mayer Erik N , Powers Christopher M 
Published: December 2019

Abstract
Over the last decade, there has been a marked increase in attention to, and interest in, femoroacetabular impingement syndrome (FAIS). Despite continued efforts by researchers and clinicians, the development, progression, and appropriate treatment of FAIS remains unclear. While research across various disciplines has provided informative work in various areas related to FAIS, the underlying pathomechanics, time history, and interaction between known risk factors and symptoms remain poorly understood. The purpose of this perspective is to propose a theoretical framework that describes a potential pathway for the development and progression of FAIS. This paper aims to integrate relevant knowledge and understanding from the growing literature related to FAIS to provide a perspective that can inform future research and intervention efforts.
A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin
Authors: McGarry Kevin G , Lalisse Remy F , Moyer Robert A , Johnson Kristyn M , Tallan Alexi M , Winters Tyson P , Taris Joeseph E , McElroy Craig A , Lemmon Erin E , Shafaat Hannah S , Fan Yamin , Deal Aniliese , Marguet Sean C , Harvilchuck Jill A , Hadad Christopher M , Wood David W 
Published: December 2019

Abstract
Chemical warfare nerve agents (CWNAs) present a global threat to both military and civilian populations. The acute toxicity of CWNAs stems from their ability to effectively inhibit acetylcholinesterase (AChE). This inhibition can lead to uncontrolled cholinergic cellular signaling, resulting in cholinergic crisis and, ultimately, death. Although the current FDA-approved standard of care is moderately effective when administered early, development of novel treatment strategies is necessary. Butyrylcholinesterase (BChE) is an enzyme which displays a high degree of structural homology to AChE. Unlike AChE, the roles of BChE are uncertain and possibilities are still being explored. However, BChE appears to primarily serve as a bioscavenger of toxic esters due to its ability to accommodate a wide variety of substrates within its active site. Like AChE, BChE is also readily inhibited by CWNAs. Due to its high affinity for binding CWNAs, and that null-BChE yields no apparent health effects, exogenous BChE has been explored as a candidate therapeutic for CWNA intoxication. Despite years of research, minimal strides have been made to develop a catalytic bioscavenger. Furthermore, BChE is only in early clinical trials as a stoichiometric bioscavenger of CWNAs, and large quantities must be administered to treat CWNA toxicity. Here, we describe previously unidentified mutations to residues within and adjacent to the acyl binding pocket (positions 282–285 were mutagenized from YGTP to NHML) of BChE that confer catalytic degradation of the CWNA, sarin. These mutations, along with corresponding future efforts, may finally lead to a novel therapeutic to combat CWNA intoxication.
Symplasmic phloem unloading and post-phloem transport during bamboo internode elongation
Authors: Deng Lin , Li Pengcheng , Chu Caihua , Ding Yulong , Wang Shuguang 
Published: December 2019

AbstractIn traditional opinions, no radial transportation was considered to occur in the bamboo internodes but was usually considered to occur in the nodes. Few studies have involved the phloem unloading and post-phloem transport pathways in the rapid elongating bamboo shoots. Our observations indicated a symplastic pathway in phloem unloading and post-unloading pathways in the culms of Fargesiayunnanensis Hsueh et Yi, based on a 5,6-carboxyfluorescein diacetate tracing experiment. Significant lignification and suberinization in fiber and parenchyma cell walls in maturing internodes blocked the apoplastic transport. Assimilates were transported out of the vascular bundles in four directions in the inner zones but in two directions in the outer zones via the continuum of parenchyma cells. In transverse sections, assimilates were outward transported from the inner zones to the outer zones. Assimilates transport velocities varied with time, with the highest values at 0):00 h, which were affected by water transport. The assimilate transport from the adult culms to the young shoots also varied with the developmental degree of bamboo shoots, with the highest transport velocities in the rapidly elongating internodes. The localization of sucrose, glucose, starch grains and the related enzymes reconfirmed that the parenchyma cells in and around the vascular bundles constituted a symplastic pathway for the radial transport of sugars and were the main sites for sugar metabolism. The parenchyma cells functioned as the ‘rays’ for the radial transport in and between vascular bundles in bamboo internodes. These results systematically revealed the transport mechanism of assimilate and water in the elongating bamboo shoots.
Treatment of Neuroma-induced Chronic Pain and Management of Nerve Defects with Processed Nerve Allografts
Authors: Ducic Ivica , Yoon Joshua , Eberlin Kyle R. 
Published: December 2019

Background:
Symptomatic neuromas can cause significant chronic pain and negatively impact quality of life. Symptoms often persist despite narcotics and nonoperative interventions, which are largely ineffective. With the opioid crisis, treatments for chronic pain that limit narcotics are needed. Traditional surgical options may result in neuroma recurrence. Autograft reconstruction often results in donor-site morbidity. Processed nerve allografts facilitate axonal growth, nerve regeneration, and eliminate donor-site morbidity.

Methods:
A literature review was performed to identify studies in which chronic neuroma pain was treated with excision and processed nerve allograft reconstruction. PubMed was queried, and data from the studies were grouped into treatment effective and ineffective groups. Statistical analyses were performed on these groups, and further subgroup analysis was performed on overall change of preoperative and postoperative pain scores using a paired t test.

Results:
Seven studies fulfilled inclusion criteria yielding 42 patients. Greater than 90% of patients had improvement of pain postoperatively. The preoperative and postoperative pain scores could be determined for 40 patients. The mean preoperative score was 7.9, and the mean postoperative score was 3.54. These results were statistically significant using a paired t test with a P value of <0.001.

Conclusions:
Chronic pain resulting from symptomatic neuromas can be treated with neuroma excision and nerve stump reconstruction with processed nerve allograft. This obviates autograft-associated donor-site morbidity and provides a platform to potentially restore sensation to the involved nerve whenever a distal nerve end is available. Addressing the root cause is an important paradigm shift for treating symptomatic neuromas.
FOVEAL SPARING INTERNAL LIMITING MEMBRANE PEELING FOR IDIOPATHIC MACULAR HOLES
Authors: Murphy Declan C. , Fostier Will , Rees Jon , Steel David H. 
Published: December 2019

Purpose:
Muller cells seem to be important in maintaining foveal morphology through connections between their foot processes and the internal limiting membrane (ILM). Internal limiting membrane peeling causes Muller cell trauma. We hypothesized that leaving a rim of unpeeled ILM around idiopathic macular holes undergoing vitrectomy surgery would improve postoperative foveal morphology and vision.

Methods:
Prospective pilot study of fovea-sparing ILM peeling in a consecutive cohort of patients with macular holes over a 12-month period. Spectral-domain optical coherence tomography and Early Treatment Diabetic Retinopathy Study letters best-corrected visual acuity were assessed preoperatively and postoperatively, and foveal morphology and metamorphopsia postoperatively. The foveal sparing group was compared with a second consecutive cohort who received standard ILM peeling (control group).

Results:
Thirty-four eyes of 34 patients were included in each group. Groups showed no significant preoperative differences. 34/34 holes were successfully closed with surgery in the foveal sparing group and 32/34 in the control group. The foveal sparing group showed better postoperative best-corrected visual acuity (67.7 vs. 63.8, P = 0.003) and best-corrected visual acuity improvement (25.1 vs. 20.2, P = 0.03). The foveal sparing group demonstrated thicker minimum foveal thickness (211 vs. 173 μm, P = 0.002) and less steep foveal depression (158 vs. 149, P = 0.002).

Conclusion:
Preserving nonpeeled ILM around macular holes resulted in a high closure rate, improved foveal morphology, and better postoperative best-corrected visual acuity. An appropriately powered randomized controlled study is warranted.
Electronic Nose Analysis of Exhaled Breath Volatiles to Identify Lung Cancer Cases: A Systematic Review
Authors: Swanson Barbara , Fogg Louis , Julion Wrenetha , Arrieta Maryan T. 
Published: December 2019

Abstract
The purpose of our review was to analyze evidence of the validity of electronic noses to discriminate persons with lung cancer from healthy control subjects and to advance implications for this technology in the care of people living with HIV. A computerized database search of the literature (published 1946–2018) was conducted to identify studies that used electronic nose-generated smellprints to discriminate persons with lung cancer from healthy control subjects. Fifteen articles met the sampling criteria. In 14 studies, mean sensitivity and specificity values from a single training sample were 84.1% and 80.9%, respectively. Five studies applied the prediction model obtained from the training sample to a separate validation sample; mean sensitivity was 88.2%, and mean specificity was 70.2%. Findings suggest that breath smellprints are valid markers of lung cancer and may be useful screening measures for cancer. No studies included people living with HIV; additional studies are needed to assess generalizability to this population.
Prognosis and Long-Term Outcome of Women With Idiopathic Recurrent Vulvovaginal Candidiasis Caused by Candida albicans
Authors: Collins Laura M. , Moore Rachelle , Sobel Jack D. 
Published: December 2019

Objectives
This study evaluated use of long-term fluconazole beyond an initial 6-month course of weekly fluconazole in premenopausal patients with idiopathic recurrent vulvovaginal candidiasis (RVVC) due to Candida albicans.

Materials and Methods
A retrospective chart review was performed of women seen in Wayne State University Vaginitis Clinic with culture-confirmed idiopathic RVVC due to Candida albicans during a 10-year period (January 2006 to December 2015). Only patients without risk factors for secondary VVC and who initiated a 6-month course of weekly fluconazole therapy were selected. Data included long-term use of fluconazole therapy, treatment efficacy, and development of fluconazole resistance. Questionnaires were mailed to evaluate patient's experience after fluconazole therapy.

Results
Of 883 patients with RVVC based on clinical records, 191 with culture positive idiopathic RVVC due to C. albicans were started on the maintenance fluconazole regimen, and 147 (77.0%) completed 6 months of therapy. Of these, 107 (72.8%) continued or received maintenance past 6 months. The most common reason for additional fluconazole therapy was culture-confirmed VVC recurrence (55.1%), unconfirmed but possible VVC recurrence (16.8%), and patient preference (10.3%). The mean duration of fluconazole maintenance was 35.7 (range = 7–288) months. Fluconazole resistance emerged in 7.5% completing 6-month therapy. Upon questionnaire follow-up, 93.6% of 51 respondents reported benefit during maintenance regimen; however, 80.9% described relapse after discontinuing weekly therapy.

Conclusions
Fluconazole suppression therapy was highly effective in preventing VVC symptoms but was rarely curative and VVC relapse occurred frequently after discontinuation of maintenance therapy. The development of drug resistance in C. albicans isolates after long-term fluconazole maintenance therapy although uncommon is a previously unrecognized complication.
Assessment of Anal Cancer Screening Tools in Detecting High-Grade Anal Squamous Intraepithelial Lesions in Women
Authors: Ramos-Cartagena Jeslie M. , Pérez Cynthia M. , Guiot Humberto M. , Amaya-Ardilla Claudia P. , Tirado-Gómez Maribel , Ortiz Ana P. 
Published: December 2019

Objective
The aim of the study was to evaluate the validity of anal cytology against high-resolution anoscopy in the detection of anal high-grade squamous intraepithelial lesions (HSILs) among women in a clinical setting in Puerto Rico, alone and in combination with high-risk human papillomavirus (HR-HPV) typing.

Materials and Methods
A cross-sectional study was done among 128 eligible women who attended the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Center between 2014 and 2019. Kappa (κ) coefficient, sensitivity, specificity, positive predictive value, and negative predictive value were calculated using high-resolution anoscopy with biopsy as the criterion standard test. Poisson regression was used to estimate the adjusted prevalence ratio of anal HR-HPV infection.

Results
Overall, 71.1% of women were HIV infected and 78.9% had anal HR-HPV infection. Squamous intraepithelial lesions were detected with anal cytology and histology in 70.3% and 81.3% of women, respectively. The κ statistic between the tests (cytology and histology) was 0.32 (p < .05). Measured against the results from histology, the sensitivity of anal cytology alone to detect HSIL was 85.4% (95% CI = 72.2%–93.9%), whereas specificity was 38.8% (95% CI = 28.1%-50.3%). Although the sensitivity of the 2 tests combined (anal cytology and HR-HPV typing) to detect histologically confirmed HSIL increased (100.0%, 95% CI = 92.6%–100.0%), the specificity decreased (16.3%, 95% CI = 9.0%–26.2%). Meanwhile, women with HSIL had a higher prevalence of anal HR-HPV infection than those with no SIL/LSIL (prevalence ratio = 6.23, 95% CI = 1.50–25.83).

Conclusions
Anal cytology in combination with HR-HPV typing for the screening of anal intraepithelial neoplasia improved the detection of HSIL in women.
Early Detection of Anal High-Grade Squamous Intraepithelial Lesion: Do We Have an Impact on Progression to Invasive Anal Carcinoma?
Authors: Maugin Florent , Lesage Anne-Carole , Hoyeau Nadia , Fléjou Jean-François , Zuber Kevin , Atienza Patrick , Etienney Isabelle 
Published: December 2019

Objective
Anal high-grade squamous intraepithelial lesion (HSIL) may precede invasive cancer and can be detected clinically or during high-resolution anoscopy (HRA). The aims of this study were to compare the characteristics of HSIL discovered by HRA or in a surgical specimen without clinically visible lesion when diagnosed versus macroscopic HSIL when first diagnosed and then to compare their progression to invasive cancer.

Patients and Methods
Clinical records of all patients with at least one HSIL lesion confirmed by histology and evaluated by HRA in a single center between September 1, 2009, and April 30, 2017, were retrospectively reviewed. The center's histological anal cancer data base was questioned in December 2017 to identify all cases.

Results
During a median (interquartile range) follow-up of 19.1 (5.6–40.2) months, 12 (2.9%) anal cancers were diagnosed in patients with a diagnosis of HSIL. Period of time between the first diagnosis of anal lesion and the cancer was 28.8 months (interquartile range = 15.4–65.6), and 11 (92%) of 12 were diagnosed as superficially invasive squamous cell carcinoma or T1N0M0. The rate of progression to anal cancer differed significantly between patients with macroscopic HSIL at diagnosis (5.4%) and patients with microscopic HSIL diagnosed during HRA (0.9%) (p = .01).

Conclusions
Patients with macroscopic histologically proven HSIL at first diagnosis of anal intraepithelial lesion have a significantly higher risk of anal cancer compared with patients with microscopic lesions diagnosed during HRA, but the duration between the first diagnosis of HSIL and cancer does not differ between the 2 groups.