bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Dose-response Relationship between BMI and Hypertension in Northeastern China Using Restricted Cubic Spline Functions
Authors: Qu Yangming , Niu HuiKun , Li Lu , Li Meiqi , Yan Shoumeng , Li Meng , Jiang Shan , Ma Xiaoyu , Li Bo , Wu Hui 
Published: December 2019

AbstractHigh body mass index (BMI) was significantly associated with hypertension. The purpose of this study is to investigate the association between BMI and hypertension in people in northeast China. Our study was a cross-sectional study conducted from June to August 2012. According to multistage, stratified cluster sampling, a total of 21435 inhabitants aged between 18 and 79 years in Jilin Province were selected randomly. The prevalence of hypertension was 35.66% overall. After adjusting for potential confounders, the multivariable-adjusted odds ratios for the BMI- hypertension association for overweight and obesity were 2.503 (95% confidence interval = 1.912–2.204) and 4.259 (95% confidence interval = 3.883–4.671). The results of multivariable restricted cubic spline regression analysis showed that there was a non-linear relationship between the continuous change of BMI and hypertension (P < 0.001) after adjusting the confounding factors of different genders and age groups, which indicated that there was an adjusted dose-response association between continuous BMI and hypertension.
Specific binding of Bacillus thuringiensis Cry1Ea toxin, and Cry1Ac and Cry1Fa competition analyses in Anticarsia gemmatalis and Chrysodeixis includens
Authors: Bel Yolanda , Zack Marc , Narva Ken , Escriche Baltasar 
Published: December 2019

AbstractAnticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays performed in first-instar larvae demonstrated potent activity against both soybean pests in terms of mortality or practical mortality. Competition-binding studies carried out with 125Iodine-labelled Cry1Ea, demonstrated the presence of specific binding sites on the midgut brush border membrane vesicles (BBMV) of both insect species. Heterologous competition-binding experiments indicated that Cry1Ea does not share binding sites with Cry1Ac or Cry1Fa in either soybean pest. This study contributes to the knowledge of Cry1Ea toxicity and midgut binding sites in A. gemmatalis and C. includens and sheds light on the cross-resistance potential of Cry1Ea with other Bt proteins aimed at controlling lepidopteran pests in soybeans.
Radon exposure is rising steadily within the modern North American residential environment, and is increasingly uniform across seasons
Authors: Stanley Fintan K. T. , Irvine Jesse L. , Jacques Weston R. , Salgia Shilpa R. , Innes Daniel G. , Winquist Brandy D. , Torr David , Brenner Darren R. , Goodarzi Aaron A. 
Published: December 2019

AbstractHuman-made buildings can artificially concentrate radioactive radon gas of geologic origin, exposing occupants to harmful alpha particle radiation emissions that damage DNA and increase lung cancer risk. We examined how North American residential radon exposure varies by modern environmental design, occupant behaviour and season. 11,727 residential buildings were radon-tested using multiple approaches coupled to geologic, geographic, architectural, seasonal and behavioural data with quality controls. Regional residences contained 108 Bq/m3 geometric mean radon (min < 15 Bq/m3; max 7,199 Bq/m3), with 17.8% ≥ 200 Bq/m3. Pairwise analysis reveals that short term radon tests, despite wide usage, display limited value for establishing dosimetry, with precision being strongly influenced by time of year. Regression analyses indicates that the modern North American Prairie residential environment displays exceptionally high and worsening radon exposure, with more recent construction year, greater square footage, fewer storeys, greater ceiling height, and reduced window opening behaviour all associated with increased radon. Remarkably, multiple test approaches reveal minimal winter-to-summer radon variation in almost half of properties, with the remainder having either higher winter or higher summer radon. This challenges the utility of seasonal correction values for establishing dosimetry in risk estimations, and suggests that radon-attributable cancers are being underestimated.
Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p
Authors: Liu Yan-yan , Zhang Li-ying , Du Wen-zhen 
Published: December 2019

Abstract
Gastric cancer (GC) is the fifth most commonly diagnosed malignancy. Paclitaxel (PTX) is an effective first-line chemotherapy drug in GC treatment, but the resistance of PTX attenuates the therapeutic effect. Circular RNA circ-PVT1 can exert the oncogenic effect in GC. But the function of circ-PVT1 involved in PTX resistance of GC is still unknown. In the present study, the expression levels of circ-PVT1, miR-124-3p and ZEB1 in PTX-resistant GC tissues and cells were detected by quantitative real-time polymerase chain reaction (RT-qPCR). PTX resistance in PTX-resistant cells was assessed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. The protein levels of Zinc finger E-box binding homeobox 1 (ZEB1), P-glycoprotein (P-gp) and glutathione S-transferase (GST-π) were detected by Western blot assay. Cell apoptosis and invasion were measured in PTX-resistant cells by flow cytometry and transwell invasion assays, severally. The interaction between miR-124-3p and circ-PVT1 or ZEB1 was predicted by starBase software, and then verified by the dual-luciferase reporter assay. The role of circ-PVT1 in PTX resistance of GC in vivo was measured by xenograft tumor model. Our results showed that circ-PVT1 expression was up-regulated in PTX-resistant GC tissues and cells. Circ-PVT1 down-regulation enhanced PTX sensitivity in PTX-resistant GC cells by negatively regulating miR-124-3p. ZEB1 served as a direct target of miR-124-3p. Circ-PVT1 enhanced ZEB1 expression by sponging miR-124-3p. Circ-PVT1 knockdown increased PTX sensitivity of GC in vivo. Taken together, our studies disclosed that circ-PVT1 facilitated PTX resistance by up-regulating ZEB1 mediated via miR-124-3p, suggesting an underlying therapeutic strategy for GC.
Medicinal Signaling Cells Metabolite Oral Based as a Potential Biocompatible Biomaterial Accelerating Oral Ulcer Healing (In Vitro Study)
Authors: Nugraha Alexander Patera , Susilowati Helen , Hendrianto Eryk , Karsari Deya , Ertanti Nora , Dinaryanti Aristika , Ihsan Igo Syaiful , Narmada Ida Bagus , Ernawati Diah Savitri , Rantam Fedik Abdul ,   Purwati
Published: December 2019

Abstract
Objective Medicinal signaling cells metabolite (MSCM) is often considered medical waste even though it contains abundant growth factors, and advantageous micro- and macromolecules that can accelerate healing in oral ulcer.The purpose of this experimental laboratory study was to analyze the biocompatibility and potential of MSCM, (oral based) to accelerate healing in oral ulcer (in vitro).
Materials and Methods MSCM (oral based) was obtained by mixing 10 mL of MSCM and 2% of carboxymethyl cellulose sodium. 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (or MTT assay) was obtained using human gingival somatic cell culture to examine cell viability treated with MSCM (oral based). Fourier transform infrared spectroscopy was performed to know the functional structure and composition of MSCM (oral based). To know the elemental composition of MSCM (oral based), energy-dispersive X-ray analysis was performed. Scratch test was performed to know the ability of MSCM (oral based) to increase human somatic cell proliferation.
Results MSCM (oral based) has good cell viability. MSCM (oral based) administration accelerated the proliferation of human somatic cell culture after 12-hours in vitro. MSCM (oral based) has carboxylic acids and derivatives chemical bond. MSCM (oral based) mostly contained carbon and potassium but did not contain heavy metal substances.
Conclusions MSCM (oral based) has a biocompatible and potential ability to accelerate healing in oral ulcer in vitro. It would be useful in daily clinical practice in treating traumatic oral ulcer.
Histomorphometric and Histopathologic Evaluation of the Effects of Systemic Fluoride Intake on Orthodontic Tooth Movement
Authors: Zorlu Fatma Yalcin , Darici Hakan , Turkkahraman Hakan 
Published: December 2019

Abstract
Objectives The aim of this study was to determine the effects of systemic fluoride intake on orthodontic tooth movement with histomorphometric and histopathologic methods.
Materials and Methods Forty-eight Wistar albino rats were randomly divided into four groups of 12 rats each. Group I received fluoridated water and underwent orthodontic tooth movement. Group II received fluoridated water and did not undergo orthodontic tooth movement. Group III received nonfluoridated water and underwent orthodontic tooth movement. Group IV received nonfluoridated water and did not undergo orthodontic tooth movement. At the beginning of the experiment (T1), impressions were taken from the maxilla of the rats in groups I and III under general anesthesia, and a NiTi closed coil spring appliance was ligated between the left maxillary central incisors and maxillary first molar. The orthodontic force applied was approximately 75 g, and the duration of the experimental period was 18 days. During the experimental period, appliances were controlled daily. At the end of the experimental period (T2), the rats were sacrificed with an overdose of a ketamine/xylasine combination, and their impressions were obtained. The upper first molars were subsequently dissected for histological examination. Incisor–molar distance, number of osteoblasts, number of osteoclasts and periodontal ligament (PDL) space widths on the compression and tension sides were measured.
Statistical Analysis All measurements were statistically analyzed with SPSS for Windows version 18.0 (SPSS Inc., Chicago, IL, USA). Repeated measures ANOVA and posthoc Tukey tests were used to compare the groups.
Results No statistically significant difference was found with respect to the amount of tooth movement between the fluoridated and nonfluoridated groups (p > 0.05). Orthodontic force application increased the number of osteoblasts at the tension sides and reduced it at the compression sides (p < 0.001). An increased number of osteoclasts was observed in the nonfluoridated group relative to the fluoridated group (p < 0.01).
Conclusions No difference was observed with respect to the amount of tooth movement between the fluoridated and nonfluoridated groups. Fluoride significantly reduced the number of osteoclasts in the experimental groups.
Assessment of Extrusion and Postoperative Pain of a Bioceramic and Resin-Based Root Canal Sealer
Authors: Fonseca Braúlio , Coelho Marcelo Santos , Bueno Carlos Eduardo da Silveira , Fontana Carlos Eduardo , Martin Alexandre Sigrist De , Rocha Daniel Guimarães Pedro 
Published: December 2019

Abstract
Objectives The objective of this study was to compare a bioceramic and a resin-based endodontic sealer with regard to extrusion and postoperative pain.
Materials and Methods Sixty-four patients requiring endodontic treatment of single-rooted maxillary teeth with necrotic pulps were included in this study. The root canal treatments were performed in a single visit using a size 40.06 single-file reciprocating system under 2.5% NaOCl irrigation. After irrigation with 17% ethylenediaminetetraacetic acid (EDTA) and 2.5% NaOCl, the canals were dried and randomly divided into two different groups (n = 32) depending on the sealer used: resin-based group (RG) in which the canals were filled with the AH Plus, and the bioceramic group (BG) in which the canals were filled with the Sealer Plus BC. Ibuprofen (600 mg) was prescribed every 6 hours if the volunteers experienced pain. The patients registered their pain sensation in a visual analog scale (VAS) card, ranging from 0 to 10 at 24-hour, 48-hour, 72-hour, and 1-week intervals. Statistical analysis  For statistical analysis, the level of significance was set at p < 0.05.
Results Sealer extrusion occurred in nine patients of the RG and in 19 patients of the BG (p < 0.05). The average pain level at 24-hour and 48-hour intervals was, respectively, 1.46 ± 1.96 and 0.44 ± 0.86 for RG, and 1.21 ± 2.09 and 0.09 ± 0.38 for BG. There was no report of pain after 48 hours. The mean number of tablets taken for pain relief was 0.03 ± 0.17 for RG and 0.06 ± 0.24 for BG. No statistically significant difference was found with regard to pain level and intake of pain killer tablets (p > 0.05).
Conclusions The BG sealer presented significantly more extrusion than the RG sealer. Sealer extrusion was not associated with pain. The average pain level and the mean number of tablets taken for pain relief were similar in both groups.
Maxillary Prosthetics, Speech Impairment, and Presidential Politics: How Grover Cleveland Was Able to Speak Normally after His “Secret” Operation
Authors: Murray Margaret , Pappas Theodore N. , Powers David B. 
Published: December 2019

AbstractIn the summer of 1893, President Grover Cleveland discovered a mass on the roof of his mouth. Two physicians examined it, determined that it was a neoplasm, and recommended resection. In an effort to avoid revealing the illness to the public, the President and his doctors boarded a yacht on July 1 1893, where the surgeons resected the affected portion of his maxilla and several teeth under an ether anesthetic. Afterward, Kasson C. Gibson, a New York dentist, created a rubber obturator, which was placed in the surgical defect in the maxilla and restored the President's facial contour and speech. Due to the precise reconstruction with the rubber appliance crafted by Gibson, the President lived the rest of his public life without facial or speech abnormality. This article will review the details of the work of Kasson Gibson and the President's maxillary prosthesis.
Co-designed strategic planning and agile project management in academia: case study of an action research group
Authors: Senabre Hidalgo Enric , Fuster Morell Mayo 
Published: December 2019

AbstractStrategic planning, a standard activity for project management in different areas and types of organisations, can contribute to improving the dynamics of collaboration in academia, and specifically in research processes. This paper joins the still scarce studies on strategic planning within research groups, contributing to the field of both team science and organisational management from a social sciences perspective and “strategy-as-practice” paradigm. Through the case study of an action research group, after the experimental co-creation of its long-term strategy involving different participatory design methodologies, we quantitatively analyze how this process influenced communication and group relations, both internally and in relation to its participation in the ecosystem with other stakeholders. Thus, as a result of a detailed content analysis in the different communication channels and tools of the group, we address its impact on the team’s agile project management (APM), adopted in a novel way by its members. Data compared between periods, once the strategic plan was co-created, suggest that this type of approach to co-created strategic thinking can improve coordination, cohesion and joint vision among participants. In agreement with emerging academic literature in this field, pertaining to the need to understand strategic planning as a process of socialization and dialogue, other relevant results of the study point to the particular suitability of this type of planning in research environments interested not only in its academic, but also social and ecosystemic impact. The results obtained and discussed also provide elements of assessment when considering the applicability of this type of strategic co-creation process in other areas of knowledge and disciplines.
An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death
Authors: Chen Natalie Y. , Yang Ye , Weston Thomas A. , Belling Jason N. , Heizer Patrick , Tu Yiping , Kim Paul , Edillo Lovelyn , Jonas Steven J. , Weiss Paul S. , Fong Loren G. , Young Stephen G. 
Published: December 2019

Significance
Deficiencies in lamin B1 or lamin B2 in mice result in markedly reduced neuronal density in the cerebral cortex, but the mechanism has been unclear. We found that deficiencies of either lamin B1 or lamin B2 cause nuclear membrane (NM) ruptures in migrating neurons, accompanied by DNA damage and cell death. Our studies were informative because they uncovered large differences in the frequency of NM repair in lamin B1- and lamin B2-deficient neurons, implying unique functions for the 2 nuclear lamins in maintaining NM integrity. Also, our studies uncovered an important role for mechanical stresses in eliciting NM ruptures, helping to explain the increased frequency of NM ruptures in migrating neurons.
Carmen Valero-Garcés & Rebecca Tipton (eds.). (2017) Ideology, Ethics and Policy Development in Public
Service Interpreting and Translation
Authors: Liu Jinhui , Wen Jun 
Published: December 2019

Abstract
This collection addresses translation and interpreting in settings of diversity and migration. It brings together
the latest research on public service interpreting and translation (PSIT) in the context of growing rights-based discourses on
language support services, with a particular focus on ideological, ethical and policy issues. Articles in this volume employ new
perspectives and draw insight from the practical field with the aim to explore the social basis and consequences of policy
development, interconnections between intricate concepts of ethics and ideology, and to stimulate debate : more discussion concerning public service
interpreting and translation among academia, the public and the third sectors to deepen the understanding of language support needs
and policy context.
Effects of genistein on lipopolysaccharide-induced injury of mouse alveolar epithelial cells and its mechanism
Authors: Zhu Qi , Zhang Wei , Mu Deguang , Zhou Hongbin , Wu Shengchang , Zou Hai 
Published: December 2019

ABSTRACT
Alveolar and bronchial epithelial cells have critical functions in acute respiratory distress syndrome progress. Genistein could protect the lungs from acute lung injury, however, whether genistein protects the alveolar epithelial cells from LPS-induced injury was less studied. Spectrophotometric method 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and enzyme-linked immunosorbent assay (ELISA) were performed to detect cell viability and levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6. Flow cytometry and western blot assay were performed to detect cells apoptosis and protein levels. In LPS-induced model of mouse lung epithelial (MLE)-12 cells, PBEF (proinflammatory cytokine) expression, and cell apoptosis were increased and cell viability was decreased, whereas NF-κB was activated and expression levels of TNF-α, IL-1β, and IL-6 were increased. However, genistein partly reversed the effect of LPS, and it plays a protective role in lung injury by reducing expression of PBEF, inhibiting the activation of NF-κB and alleviating inflammatory response of cells.
Meristic characters and length-weight relation of climbing perch (Anabas testudineus) from wetlands in Sigi District, Central Sulawesi, Indonesia
Authors: Ndobe S , Rusaini  , Masyahoro A , Serdiati N , Madinawati  , Moore A M 
Published: December 2019

Abstract
The climbing perch, Anabas testudineus Bloch 1972, is a valued freshwater fish with a wide distribution in South and Southeast Asia. This study examined the meristic counts and length-weight relation of climbing perch from Sigi District, Central Sulawesi, Indonesia, close to the eastern extremity of the species distribution. Specimens collected from wetlands in Sigi District were weighed and measured (total length) to derive length–weight relation (n = 265) and meristic counts (n = 140). Length (L, in mm) – weight (W, in g) relation (W = a·Lb) parameter b = 2.98 overall; for females b = 3.06 while for males b = 2.88. Maximum length Lmax was 163 mm. The meristic formula using median values was D, XVII+8; A, X+9; P, 13; V, I+5; C, 16. Mean scale counts for both male and female climbing perch were: longitudinal 31 and vertical 15. There was no significant between-sex difference in meristic characters. Although the average growth pattern was isometric, males exhibited a slight allometric negative tendency. Low maximum size is consonant with other indications of a population under pressure, reinforcing the need for sustainable, holistic wetland management. In the context of domestication, high variability in meristic characters may indicate high genetic diversity and/or plasticity, which could provide scope for selective breeding.
Production of Pacific whiteleg shrimp, Litopenaeus vannamei through implementation of rapid biofloc technology
Authors: Kasan N A , Kamaruzzan A S , Rahim A I A , Ishak A N , Jauhari I , Ikhwanuddin M 
Published: December 2019

Abstract
A green technology known as rapid biofloc was implemented to reduce environmental damage while improving production of Pacific whiteleg shrimp, Litopenaeus vannamei to meet global market demand. Since there was no intensive application of biofloc technology being implemented at an industrial scale, this study aimed to assess the effect of biofloc in order to optimize water quality and maximize overall shrimp production. To speed-up the development of biofloc in L. vannamei cultures, an isolated biofloc boost-up bacteria inoculum was added during a new shrimp post-larvae (PL) stocking program. Samples of water, shrimp and biofloc were collected at ten day intervals from the new stocking of shrimp PL until harvest time (±100 days). Biofloc was observed starting to form as early as 10 days after shrimp the cultivation period began, and biofloc formation was speeded up by the addition of the inoculum. The biofloc effectively enhanced good water quality which resulted in an increase in shrimp biomass. The rapid biofloc formation and aggregation of beneficial microbes in the biofloc were responsible for maintaining good water quality and optimizing shrimp survival and production. Therefore, knowledge on the microbial composition in biofloc is deemed important for the successful design and application of biofloc technology to support a sustainable shrimp aquaculture industry.
The effect of commercial feed enrichment with Piper betle leaf extract on the growth and survival rate of tilapia (Oreochromis niloticus)
Authors: Agustina S S 
Published: December 2019

Abstract
This research aimed to examine effect of commercial feed enrichment with Piper betle leaf extract on the growth and survival rate of tilapia (Oreochromis niloticus). This study used an experimental method with 15-20 g tilapia seed as test organisms at a stocking rate of 150 fish/m2. A Completely Randomized Design was used with five treatments and three replicates. The treatments were: A (pelleted feed/control); B (10% Piper betle leaf extract/kg feed); treatment C (15% Piper betle extract/kg feed); treatment D (20% Piper betle leaf extract/kg feed); and treatment E (25% betel leaf extract/kg of feed). The parameters observed during this study were the net increase in biomass and survival rate of the tilapia seed. All data were tabulated, then analysed using an analysis of variance (ANOVA). Water quality parameters in each treatment remained within acceptable limits for tilapia grow-out throughout the study, with pH 6.0–7.96; temperature 27.1 - 34.8 °C; DO 3.7 - 4.8 ppm and 0 ppm ammonia. The Piper betle leaf extract concentration in treatment D (20%) gave the best results, with 342.33 ± 10.60 g net increase in tilapia seed biomass and 100%± 0% survival rate.