bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA BTBD7_hsa_circ_000563 in human coronary artery
Authors: Chen Jia-Xin , Hua Lei , Zhao Chen-Hui , Jia Qiao-Wei , Zhang Jing , Yuan Jin-Xia , Zhang Yong-Jie , Jin Jian-Liang , Gu Mu-Feng , Mao Zhi-Yuan , Sun Hai-Jian , Wang Lian-Sheng , Ma Wen-Zhu , Jia Enzhi 
Published: March 2020

Abstract
Background: To investigate the association of BTBD7_hsa_circ_000563 expression in coronary artery segments with atherosclerotic stenosis, and to explore the proteome-wide identification of the BTBD7_hsa_circ_000563-regulated proteins in coronary artery Methods: The coronary artery samples were obtained from two autopsy cases. The epicardial coronary artery of every autopsy was divided into 10 segments, and coronary atherosclerosis grade and extent of the coronary artery segments were analysed by Haematoxylin and Eosin (H&E) staining. The BTBD7_hsa_circ_000563 expression of 8 segments from case 2 was quantified using RT-qPCR analysis. Results: The present study demonstrated that coronary artery segments with severe atherosclerotic stenosis showed extremely low expression of the BTBD7_hsa_circ_000563, compared with normal coronary artery segments. Furthermore, it was predicted that hsa-miR-155-5p, and hsa-miR-130a-3p are targets of the BTBD7_hsa_circ_000563. The results from the present study may laid an epigenetic foundation for studying the underlying mechanisms of the development and progression of coronary artery atherosclerosis. Conclusions: BTBD7_hsa_circ_000563 were involved in atherosclerotic changes in coronary artery segments of human being, and the verification study, mechanism study, and function study are necessary in order for CAD patients to benefit from the personalized medicine in the future.
Control of the tomato leaf miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) larvae in laboratory using entomopathogenic nematodes from subtropical environment
Authors: Dlamini Bonginkhosi E. , Dlamini Nelisiwe , Masarirambi Michael T. , A. Nxumalo Kwanele 
Published: March 2020

Abstract
Tomato (Solanum esculentum) is one of the vegetable crops grown by both smallholder and commercial farmers in the Kingdom of Eswatini. Tomato leaf miner, Tuta absoluta M. is a major insect pest of tomatoes resulting in reduced tomato yields throughout the country. The study investigated the virulence of two sub-tropical EPN species on T. absoluta larvae. Steinernema yirgalemense and S. jeffreyense at different concentrations (0, 20, 40, 60 IJs/insect) were screened for efficacy (i.e. mortality rate) against larvae of T. absoluta in laboratory bioassays. Results obtained showed that S. yirgalemense and S. jeffreyense were able to kill T. absoluta larvae without significant differences between the two EPN species in 24-well bioassay trays. Significantly higher (p < 0.05) mortality was observed when 60 IJs/insect was used. The combination of S. yirgalemense at 60 IJs/insect (100%) and S. jeffreyense at 60 IJs/insect (98.3%) resulted in significantly higher (p < 0.05) mortality, compared with the other four combinations of EPN and concentration tested. In the leaf bioassays, S. yirgalemense (58.8%) resulted in significantly higher (p < 0.05) mean mortality compared to S. jeffreyense (46.4%). Steinernema yirgalemense at 60 IJs/insect resulted in significantly higher mean mortality compared to the other EPN and concentration combinations in the leaf bioassay. The results indicated that both EPNs tested were effective against T. absoluta larvae. Steinernema yirgalemense at 60 IJs/insect can effectively find T. absoluta larvae inside leaf mines, but large-scale field trials are recommended to demonstrate the potential use of the biocontrol agent within integrated pest management programs.
Information-analytical assessment systems for perinatal outcomes and children’s health status born by assisted reproductive technologies
Authors: Kovtun O. P. , Plaxina A. N. , Makutina V. A. , Ankudinov N. O. , Zilber N. A. , Limanovskay O. V. , Sinotova S. L. 
Published: March 2020

Purpose: To integrate clinical databases based on the information and analytical systems of medical organizations (MO) and to evaluate outcomes and health of children born by assisted reproductive technologies (ART).Research methods: To form database by integrating information and analytical systems of the medical organizations. To search and unify the data by means of freeware relational database management system (DBMS) – MySQL.Results. A prototype application for the management and support of a unified clinical database to analyze and evaluate the outcomes of ART. To compare information from individual databases of MO one need to match fields in the form of unique personal records, field validation, processing of missing data. Significant (p <0.001) differences in gestational age and anthropometric data in the databases of medical organizations (76% of full-term children from the Automated System “Regional obstetric monitoring” (AS ROM) database compared with 18% according to the IS “Register of Children requiring Early Care”) were determined by the introduction of the conception of ART, along with the presence of perinatal risk factors in children. The created software can be used to create registers of medical organizations, as well as to support clinical decision-making in forecasting, modeling outcomes and children’s health after ART, developing personalized treatment and rehabilitation programs.Conclusion. It is necessary to develop and implement information systems, to create ART registers on the basis of regional and national registers, to analyze the outcomes of the use of reproduction methods.
The state of the digestive system in children with systemic connective tissue diseases
Authors: Chyzhevskaya I. D. , Belyaeva L. M. 
Published: March 2020

Purpose. To study the prevalence of the digestive system pathology in children with systemic connective tissue diseases.Characteristics of children and research methods. We carried out a clinical and instrumental examination of 108 children with systemic connective tissue diseases hospitalized in the rheumatology department of the 4th City Children’s Clinical Hospital in Minsk from 2008 to 2015. 60 patients suffered from juvenile idiopathic arthritis (mean age 12.3 [9.4; 15.6] years), 23 children suffered from juvenile scleroderma (mean age 11.8 [9.7; 14.9] years) and 25 children suffered from systemic lupus erythematosus (mean age 13.1 [12.2; 16.3] years). All patients received long-term immunosuppressive and anti-inflammatory therapy.Results. 75.9% patients had gastroenterological complaints, such as abdominal pains, nausea, heartburn. 69.4% of patients had endoscopic changes in the esophagus, stomach, and/or duodenum. According to the results of the morphological study, 43.5% of patients with systemic connective tissue diseases had mild inflammatory process, 29.6% of patients had average inflammatory process, and 3.7% of patients had severe inflammatory process. Among the children examined, 33 (55%) patients with juvenile idiopathic arthritis, 12 (48%) children with systemic lupus erythematosus and 11 (47.8%) patients with juvenile scleroderma were infected with Helicobacter pylori. Pathological changes of the hepatobiliary system and pancreas were diagnosed in 83.3% of children with systemic connective tissue diseases.Conclusion. The revealed changes indicate a probable connection between the pathology of the digestive organs in children with systemic connective tissue diseases and substantiate the gastroenterological examination of this category of patients.
Clinical and epidemiological characteristics of measles in the Astrakhan region in 2013–2019
Authors: Kharchenko G. A. , Kimirilova O. G, 
Published: March 2020

In the first quarter of 2019, we registered 872 cases of measles in Russia, indicating a tense epidemic situation of this disease.Purpose.To determine clinical and epidemiological features of measles in the Astrakhan region (AR) from January 2013 to April 2019.Material and methods.We analyzed 663 cases of measles confirmed by enzyme immunoassay (293 children + 370 adults) in the AR from January 2013 to April 2019.Results.We found that in the age structure of measles incidence in AO prevail patients aged from 18 to 29 years old, unvaccinated or lacking vaccination information, unvaccinated children of 1-2 years old and children under 1 year old, not subject to measles vaccination. The main reasons for the lack of vaccination in children with measles under 17 years are medical withdrawal; and among adults – insufficient vaccination of people under 35 years and the absence of vaccination in people over 35 years. The main reasons for the incidence of measles among vaccinated children and adults is the violations of vaccination, inaccuracy of official measles vaccination data, which is confirmed by serological monitoring, indicating a decrease in the seropositive individuals among vaccinated persons. The presence of measles foci and the spread of infection can be explained by nosocomial outbreaks, spread of measles in the organized groups as a result of untimely identification and isolation of patients. Measles in children and adults of different age groups, both vaccinated and unvaccinated, occurred typically with a predominance of moderate form. The Filatov – Koplik symptom, despite its detection in only 54% of patients, remains the main sign for the diagnosis of measles in the catarrhal period of the disease, and pigmentation is a sign of the past illness.
Optimization of microalgae harvesting by sedimentation induced by high pH
Authors: Leite Luan de Souza , Daniel Luiz Antonio 
Published: March 2020

Abstract
Microalgae harvesting is a major hurdle for the production of high-value microalgal bioproducts on a large scale. Among harvesting techniques, pH-induced sedimentation stands out as an inexpensive and technically viable method. Nevertheless, there is little information available on the application of this method for microalgae cultivated in wastewater. In this context, the present study investigated the optimization of sedimentation parameters for Chlorella sorokiniana harvesting from wastewater. Parameter optimization was statistically determined by the response surface methodology. The optimal values included a velocity gradient of 250 s−1, mixing time of 10 seconds, and pH of 12, which enabled microalgae harvesting efficiencies of more than 97.8%. These optimal parameters also showed resilience through the physico-chemical variation of the photobioreactor effluent. Furthermore, wastewater quality improved significantly after microalgae harvesting. High removal was found for turbidity (97.9–98.3%), apparent color (92.2–97.2%), total Kjeldhal nitrogen (91.0–94.4%), and total phosphorus (92.8–98.6%). Centrifugation, as the dewatering method, and its operational parameters were also evaluated. Sedimentation followed by centrifugation increased the initial microalgae concentration by about 123 times. This study shows the importance of operational optimization and the results can be used as practical guidelines for microalgae harvesting on a large scale.
Using the Technology Acceptance Model to Explore Adolescents’ Perspectives on Combining Technologies for Physical Activity Promotion Within an Intervention: Usability Study
Authors: Drehlich Mark , Naraine Michael , Rowe Katie , Lai Samuel K , Salmon Jo , Brown Helen , Koorts Harriet , Macfarlane Susie , Ridgers Nicola D 
Published: March 2020

Background
Wearable activity trackers and social media have been identified as having the potential to increase physical activity among adolescents, yet little is known about the perceived ease of use and perceived usefulness of the technology by adolescents.

Objective
The aim of this study was to use the technology acceptance model to explore adolescents’ acceptance of wearable activity trackers used in combination with social media within a physical activity intervention.

Methods
The Raising Awareness of Physical Activity study was a 12-week physical activity intervention that combined a wearable activity tracker (Fitbit Flex) with supporting digital materials that were delivered using social media (Facebook). A total of 124 adolescents aged 13 to 14 years randomized to the intervention group (9 schools) participated in focus groups immediately post intervention. Focus groups explored adolescents’ perspectives of the intervention and were analyzed using pen profiles using a coding framework based on the technology acceptance model.

Results
Adolescents reported that Fitbit Flex was useful as it motivated them to be active and provided feedback about their physical activity levels. However, adolescents typically reported that Fitbit Flex required effort to use, which negatively impacted on their perceived ease of use. Similarly, Facebook was considered to be a useful platform for delivering intervention content. However, adolescents generally noted preferences for using alternative social media websites, which may have impacted on negative perceptions concerning Facebook’s ease of use. Perceptions of technological risks included damage to or loss of the device, integrity of data, and challenges with both Fitbit and Facebook being compatible with daily life.

Conclusions
Wearable activity trackers and social media have the potential to impact adolescents’ physical activity levels. The findings from this study suggest that although the adolescents recognized the potential usefulness of the wearable activity trackers and the social media platform, the effort required to use these technologies, as well as the issues concerning risks and compatibility, may have influenced overall engagement and technology acceptance. As wearable activity trackers and social media platforms can change rapidly, future research is needed to examine the factors that may influence the acceptance of specific forms of technology by using the technology acceptance model.

Trial Registration
Australian and New Zealand Clinical Trials Registry ACTRN12616000899448; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370716
El pluralismo moral de David Hume
Authors: Arrieta Agustín , Vicente Agustín 
Published: March 2020

En este trabajo se propone una interpretación del pensamiento moral de David Hume y se argumenta a favor de un pluralismo objetivista. En una primera aproximación se aborda la distinción pluralismo/relativismo en el ámbito de la estética. A continuación, ya en el ámbito de la moral, se exponen las razones que permiten justificar que Hume sea considerado, en primera instancia, un pluralista normativo y, en última, un pluralista objetivista. Nuestro argumento hace uso de la idea humeana de que hay cuatro fuentes de valor, y del concepto de vida/moral artificial.
Explicar y contrastar
Authors: Ginnobili Santiago , Carman Christián 
Published: March 2020

Usualmente se ha asumido que una única distinción puede dar cuenta del papel que cumplen los conceptos en una teoría respecto de la contrastación y respecto de la explicación. Intentaremos mostrar que esta asunción es incorrecta. Por una parte, no hay razones para considerar que esta coincidencia deba darse y, por otra, como pretenderemos probar a partir de varios ejemplos, de hecho, no se da. La base de contrastación de una teoría no tiene por qué coincidir con el explanandum de la teoría. Para defender este punto asumiremos el estructuralismo metateórico, y se extraerán consecuencias para la concepción metateórica presupuesta.
Capacidades resilientes en docentes ante casos de violencia intrafamiliar
Authors: Oviedo Amalia Daniela , Tarazona Meza Katherine , Lorena Ramírez Angie 
Published: March 2020

La investigación tuvo como objetivo identificar las capacidades resilientes que poseen los docentes de la Escuela General Básica Fiscal 24 de Mayo N°2, ubicada en la ciudad Portoviejo, Ecuador, en el afrontamiento de casos de violencia intrafamiliar. La metodología utilizada fue de tipo cuali-cuantitativo, a través de métodos descriptivos y deductivos. Los instrumentos fueron el test SV-RES (Saavedra & Villalta, 2008) –para medir la resiliencia–, la encuesta y la entrevista semiestructurada. La investigación fue realizada con 47 docentes, cantidad que constituye el 100% de la población, durante los meses de septiembre y octubre del año 2019. Los resultados arrojaron que, en general, los docentes poseen capacidades resilientes promedio y alta, y que en el afrontamiento de estos casos cuentan con rutas y protocolos a seguir para la detección y derivación de estos; sin embargo, utilizan también sus habilidades personales para saber sobrellevar los casos de violencia intrafamiliar.
Pengaruh Strategi Pembelajaran Koperatif Tipe Investigasi Kelompok Terhadap Hasil Belajar Pkn Siswa Kelas VI SD
Authors: Mandriani Ni Nyoman 
Published: March 2020

This study aims to determine the differences in learning outcomes between students who take the Civics with cooperative learning strategies and investigations group of students who take lessons with conventional teaching model in class VI students of SD Negeri 2 Datah, Abang, Karangasem academic year 2016/2017.This research is a quasi experimental study . The study populationwas all students of class XI of SD Negeri 2 Datah Karangasem academic year 2016/2017 , amounting to 115 people . The study sample is a class VI student of SD N 2 Datah which were 25 students of class VI. Data on students' learning outcomes Civics obtained through a written test conducted at the end of the lesson . The data obtained were then collected and analyzed using descriptive statistical analysis and inferential statistics (test ).Based on the analysis of data , obtained thit = 13.20 and ttab ( at significance level of 5 % ) = 2.00. Obtained average (x) count , the experimental group was 26.9 and the control group was 16.73 . This means that the experimental > control , so it can be concluded that the model of learning group investigastion affect learning outcomes Civics class VI students of SD N 2 Datah regency of Karangasem
Pengaruh Model Discovery Learning Berbantuan Media Audio Visual dalam Setting Lesson Study Terhadap Hasil Belajar IPA Mahasiswa PGSD Undiksha UPP Denpasar Tahun 2017
Authors: Lestari Komang Putri 
Published: March 2020

This research is intended to know the influence of NHT model by audio visual media toward the mastery of science competence of fourth grade students of SD Gugus Yos Sudarso in academic year 2016/2017. Type of research conducted in this research is quantitative research with experimental design that is quasi experiment (Experimental Semu). The experimental design used is "Nonequivalent control group design". In the two samples that have been drawn are one group of expreiments and one control group. Class IVB SDN 12 Sanur as experimental group and grade IVC SDN 10 Sanur as control group. The learning in the experimental and control class is equally given 6 times, and is given the last postet to know the improvement of the knowledge competence of science knowledge. To collect data in this research is done by test method. The data obtained were analyzed using the t-test. The results of data analysis obtained thitnung = 6,536 while at the level of significance 5% and dk = 68 obtained t table = 2,000 so thitung = 6,536 > t table = 2,000. Based on the test criteria, Ho is rejected and Ha accepted. The average value of science knowledge competence in the group that was taught with NHT model with audio visual aid was 80.17, while in the group taught by conventional learning was 68,66. So it can be concluded that Model Type NHT Assisted Audio Visual Media influence on the mastery of knowledge competence of science class IV elementary school Gugus Yos Sudarso District South Denpasar Lesson 2016/2017.
PEMBELAJARAN TARI JEPEN DAPAT MENINGKATKAN KECERDASAN KINESTETIK PADA ANAK USIA 5-6 TAHUN DI KELOMPOK BERMAIN DARUSSAKINAH 02 TENGGARONG SEBERANG TAHUN AJARAN 2016 / 2017
Authors: Arbibah Arbibah - , Brantasari Mahkamah - , Khairunnisa Ratna - 
Published: March 2020

This study aims to improve students’ Kinestetik intelegence through basic movement of jepen dance,i.e : Butterfly dance for 5-6 year old in Darussakinah 02 Playgroup Tenggarong Seberang. Therefore, The researcher conducted a classroom actionresearch to improve the quality of achievenment. In each cycle, the researcher applied four stages; planning, implementation, observation, andreflection. In this study, the researcher employed two cycles with four meetings in each eycle. Moreover, the observed aspects in this study were coordination among body movement, eyes, hands, and legs, strength, agility and balance. This research was conducted in Darussakinah 02 Playgroup Tenggarong Seberang on February 2017. The researcher involved ten 5-6 year old students of Darussakinah 02 Playgroup as the research subjects, consisting five males dan five femals. To gather the data, the researcher employed technique, documentation and performance test. Having analyzed the data, it is found that, in cycle 1, 50,7 % students were active in responding the lesson for preparing the basic movementof dance. Meanwhile, at cycle 2, 80,5 % students managed to do the dance movement. Considering the increasing percentage in cycle 2 compared with cycle 1, it can be said that student experienced progress. In brief, students’ kinesthetic intelligence was successfully improved through the implementation of Jepen Dance From Kutai, which has been recreated into Buterfly Jepen Dance and Performed in group.
MENANAMKAN NILAI-NILAI KARAKTER BERPOLA PEMBIASAAN PERILAKU DI TAMAN KANAK- KANAK ROSIHAN ANWAR
Authors: Ashar Ashar - , Sadaruddin Sadaruddin - 
Published: March 2020

The purpose of this study is to inculcate character values based on patterns of habitualizing behavior in early childhood, so that they can contribute actively behaving in positive activities that are fun in raising the character values. This research method is to describe the condition of "what is" in an inculcation of character values, so this research uses a descriptive qualitative approach. Therefore, the data analysis technique used in this research is descriptive analysis, data obtained from interviews, observations, documentation, followed by describing, analyzing and interpreting in depth especially data relating to the inculcation of character values patterned in habitual behavior in kindergartens - Kid. To analyze the data begins data reduction, data display, conclusions and verification. Furthermore the validity of the data to obtain the level of confidence in the truth of the results of research. The results of the study Habit positive behavior based on what is seen, heard and felt by students to be emulated in everyday life, so that habituation is carried out in the family environment and school environment (kindergarten). If positive behavior is ingrained in children from an early age, then the students will find it difficult to change their habits so they can get used to behaving wherever the child goes. Behavior habits are inherent in children of course children have automatic behaviors without thinking too much consideration for positive behavior. Application of character values to the pattern of habitual behavior in kindergarten which is an effort to instill the values of religious character, honest, tolerance, discipline, hard work, creative, independent, democratic, curiosity, national spirit, love of the motherland, respect for achievement friendly, care about the environment, care about social, responsibility. All of these character values require a process and collaboration on the elements that are related between the family, educators and the community to jointly stimulate the child's developmental abilities.Â Â