bluuebunny/crossref_metadata_2025_split huggingface dataset:
Issues beyond resistance: inadequate antibiotic therapy and bacterial hypervirulence
Authors: Goneau Lee W , Delport Johannes , Langlois Luana , Poutanen Susan M , Razvi Hassan , Reid Gregor , Burton Jeremy P 
Published: October 2020

ABSTRACTThe administration of antibiotics while critical for treatment, can be accompanied by potentially severe complications. These include toxicities associated with the drugs themselves, the selection of resistant organisms and depletion of endogenous host microbiota. In addition, antibiotics may be associated with less well-recognized complications arising through changes in the pathogens themselves. Growing evidence suggests that organisms exposed to antibiotics can respond by altering the expression of toxins, invasins and adhesins, as well as biofilm, resistance and persistence factors. The clinical significance of these changes continues to be explored; however, it is possible that treatment with antibiotics may inadvertently precipitate a worsening of the clinical course of disease. Efforts are needed to adjust or augment antibiotic therapy to prevent the transition of pathogens to hypervirulent states. Better understanding the role of antibiotic-microbe interactions and how these can influence disease course is critical given the implications on prescription guidelines and antimicrobial stewardship policies.
Within- and Between-Person Relationships Among Health, Awareness of Aging, and Control Beliefs: A Microlongitudinal Study
Authors: Zhang Shenghao , Neupert Shevaun D 
Published: October 2020

Abstract

Objective
Control beliefs are bidirectionally related to physical and cognitive health, and control beliefs are associated with awareness of aging (subjective age and awareness of age-related change [AARC]), but it is unclear how these processes unfold within persons over time. We examine these relationships from both between- and within-person perspectives.
Methods: Older adults (n = 116) ranging in age from 60 to 90 (M = 64.71) completed a 9-day daily diary study online, resulting in 743 total days. Participants reported their sociodemographic characteristics on Day 1 and physical symptoms, memory failures, felt age, daily AARC gain and loss experiences, and control beliefs on Days 2–9.

Results
Within-person deviations from one’s typical awareness of aging (AARC losses, AARC gains, and subjective age) were associated with fluctuations in control beliefs. Multilevel mediation results showed that between-person AARC losses mediated the relationship between health (both physical symptoms and memory failures) and control beliefs, whereas both within- and between-person control beliefs mediated the relationship between physical health and AARC losses. Model fit comparisons showed that models with control beliefs mediating health and awareness of aging fit better than models with awareness of aging mediating health and control beliefs.

Discussion
Our findings suggest that within-person physical and cognitive health indicators were associated with awareness of aging indirectly through control beliefs. Although between-person differences in AARC losses may link health and control beliefs, our results suggest that a more consistent pattern involves control beliefs linking health and awareness of aging.
Promoting Britain’s fight: Duff Cooper’s 1939–40 lecture tour and American public opinion during the ‘Phoney War’
Authors: Hart Bradley W , Carr Richard 
Published: October 2020

Abstract
From October 1939 to March 1940, Conservative member of parliament Alfred Duff Cooper and his wife Diana toured the United States. Their public appearances drew thousands of audience members and provoked the ire of isolationists, but the true importance of the Coopers’ tour lay in the conversations they undertook with prominent Americans. This article examines the controversy surrounding the Coopers’ wartime tour of the U.S., the significance of the trip and the conclusions both drew from their visit. These would have a demonstrable impact on British public relations efforts, particularly after Duff Cooper’s appointment as minister of information.
The development of a flexible heart model for simulation-based training
Authors: Man Jelle , Maessen Jos , Sardari Nia Peyman 
Published: October 2020

Abstract

OBJECTIVES
Simulation-based training has shown to be effective in training new surgical skills. The objective of this study is to develop a flexible 3-dimensional (3D)-printed heart model that can serve as a foundation for the simulation of multiple cardiovascular procedures.

METHODS
Using a pre-existing digital heart model, 3D transoesophageal echocardiography scans and a thoracic CT scan, a full volume new heart model was developed. The valves were removed from this model, and the internal structures were remodelled to make way for insertable patient-specific structures. Groves at the location of the coronaries were created using extrusion tools in a computer-modelling program. The heart was hollowed to create a more flexible model. A suitable material and thickness was determined using prior test prints. An aortic root and valve was built by segmenting the root from a thoracic CT scan and a valve from a transoesophageal echocardiogram. Segmentations were smoothed, small holes in the valves were filled and surrounding structures were removed to make the objects suitable for 3D printing.

RESULTS
A hollow 3D-printed heart model with the wall thicknesses of 1.5 mm and spaces to insert coronary arteries, valves and aortic roots in various sizes was successfully printed in flexible material.

CONCLUSIONS
A flexible 3D-printed model of the heart was developed onto which patient-specific cardiac structures can be attached to simulate multiple procedures. This model can be used as a platform for surgical simulation of various cardiovascular procedures.
None of the Above: Protest Voting in the World's Largest Democracy
Authors: Ujhelyi Gergely , Chatterjee Somdeep , Szabó Andrea 
Published: October 2020

AbstractWho are “protest voters” and do they affect elections? We study this question using the introduction of a pure protest option (“None Of The Above” (NOTA)) on Indian ballots. Using structural estimation, we find that in elections without NOTA, most protest voters simply abstain. Protest voters who turn out scatter their votes among many candidates and consequently have little impact on election results. From a policy perspective, NOTA may be an effective tool to increase political participation, and can attenuate the electoral impact of compulsory voting.
Intellectuals Debate #MeToo in China: Legitimizing Feminist Activism, Challenging Gendered Myths, and Reclaiming Feminism
Authors: Ling Qi , Liao Sara 
Published: October 2020

AbstractThis study focuses on the intellectual debate over #MeToo in China provoked by an article written by a well-known Chinese scholar and public intellectual Liu Yu. Raising such countervailing issues as women’s supposed complicity in sexual harassment and the drawbacks of digital activism in comparison with legal action, Liu’s article marked a crucial moment in the public awareness and discussion of #MeToo and digital activism in China in 2018. By analyzing the critical responses to Liu’s argumentations, we examined the discursive impact of these critical efforts to destabilize Liu’s hegemonic reading of the sexual harassment culture in China. We show how Liu’s critics offered a compelling defense of #MeToo, deconstructed enduring gendered myths, and had a significant impact in terms of reclaiming feminism in China. We argue further that the critics’ intellectual and deliberative efforts exemplify China’s local struggles in the global #MeToo movement and feminist activism.
Domains of Polarity Items
Authors: Homer Vincent 
Published: October 2020

AbstractThis article offers a unified theory of the licensing of Negative and Positive Polarity Items (PIs), focusing on the acceptability conditions of PPIs of the some-type, and NPIs of the any-type. It argues that licensing has both a syntactic and a semantic component. On the syntactic side, the acceptability of PIs is checked in constituents; in fact, for any given PI, only some constituents, referred to as `domains', are eligible for the evaluation of that PI. The semantic dimension of licensing consists in the sensitivity of PIs to the monotonicity properties of the syntactic environments they find themselves in. Two pieces of evidence support the semantic dimension of what I call the ‘environment-based’ approach defended here: (i.) PIs are subject to flip-flop and (ii.) certain inferences affect their acceptability by modifying the monotonicity of their environment. A third property, called ‘entanglement’ and so far unnoticed, is described: the acceptability of PIs depends on the acceptability of other PIs in the same syntactic environment. The latter property is exploited to determine what semantic property some is sensitive to: it turns out that, contrary to the consensus among researchers, some is acceptable in the complement of the set of environments in which any is acceptable, and vice versa.
Sociodevelopmental Challenges Faced by Young People with Chronic Pain: A Scoping Review
Authors: Jones Abigail , Caes Line , McMurtry C Meghan , Eccleston Christopher , Jordan Abbie 
Published: October 2020

AbstractObjectiveMap the current literature investigating autonomy development, identity development, and peer relationships in young people aged 10–24 years with chronic pain.MethodsA scoping review method was used to systematically search four databases (APA PsycNET, PubMed, Web of Science, and Cinahl) for peer-reviewed articles. Search results were screened against inclusion and exclusion criteria to ensure they met the objective. Eligible papers were assessed for quality, their data relating to the objective were extracted, and results are synthesized.ResultsSearches returned 3,815 papers after the removal of duplicates, with 42 papers included in the full review. The majority of papers investigated peer relationships (86%). Fewer papers investigated autonomy (43%) and identity (21%) development. Included papers were mostly quantitative (64%), with fewer qualitative (34%) and mixed-methods papers (2%). Overall, we found bidirectional relationships between chronic pain in young people, their social development, and a range of functional outcomes. However, the mechanisms underlying these relationships remain relatively unexplored.ConclusionsReview results are mapped onto the model proposed by Palermo et al. (2014). Guided by this model, clinical treatment for young people with chronic pain should consider social development. The model also sets out a future research agenda focused on exploring: (a) identity development, (b) the mechanisms underlying the relationships between social–developmental domains, pain, and outcomes, (c) a variety of participants and populations, and (d) a variety of methods, including longitudinal study designs.
Romantic Relationships in Young People with Long-Term Health Conditions: A Scoping Review
Authors: Jordan Abbie , Carter Bernie , Forgeron Paula , Fournier Karine , Sanders Kate 
Published: October 2020

AbstractObjectiveForming and maintaining romantic relationships is an important developmental task in adolescence and young adulthood. This scoping review seeks to explore how young people with long-term physical health conditions understand and experience romantic relationships.MethodsUsing Arksey and O’Malley’s scoping review framework, a systematic search of five databases was conducted (PsychINFO, Cinahl, MEDLINE, Embase, and Web of Science). Studies were eligible for inclusion in the review if they were published in peer-reviewed journals, used primary data collection methods, and adopted quantitative, qualitative, or mixed-methods approaches to study romantic relationships in 11–25 year olds with long-term physical health conditions. Using a data extraction form, data pertaining to demographic characteristics of young people with long-term physical health conditions and relationship engagement were extracted from eligible papers.ResultsSearches returned 4645 papers after duplicate removal, with a two-stage screening process resulting in 111 full-text papers being reviewed. Thirty-three eligible papers were included across a range of long-term physical health conditions. Findings identified that living with a long-term physical health condition impacted young people’s perceptions and experiences of romantic relationships across the relationship lifespan, from envisaging future relationships, to forming relationships, and sustaining relationships. Issues around body confidence and self-esteem were identified as challenging in terms of perceptions and experiences of romantic relationships.ConclusionsFindings demonstrate that young people wish to engage with romantic relationships, yet many report particular challenges associated with forming and sustaining relationships due to the constraints of their condition and treatment. Future research should consider nonheterosexual relationships.
Secret Codes & Oppressive Histories
Authors: Bliss Jackson 
Published: October 2020

Abstract
In this short story with an oscillating point of view and a secret coded message, an estranged hapa daughter and her Japanese American father are about to meet for the first time in fifteen years as they retell their stories separately of moving from town to town in Michigan as drivers and passengers, a power dynamic that doubles as generational, gender, hierarchical, and positional signifiers in their own relationship.
crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays
Authors: Störtz Florian , Minary Peter 
Published: October 2020

Abstract
With ongoing development of the CRISPR/Cas programmable nuclease system, applications in the area of in vivo therapeutic gene editing are increasingly within reach. However, non-negligible off-target effects remain a major concern for clinical applications. Even though a multitude of off-target cleavage datasets have been published, a comprehensive, transparent overview tool has not yet been established. Here, we present crisprSQL (http://www.crisprsql.com), an interactive and bioinformatically enhanced collection of CRISPR/Cas9 off-target cleavage studies aimed at enriching the fields of cleavage profiling, gene editing safety analysis and transcriptomics. The current version of crisprSQL contains cleavage data from 144 guide RNAs on 25,632 guide-target pairs from human and rodent cell lines, with interaction-specific references to epigenetic markers and gene names. The first curated database of this standard, it promises to enhance safety quantification research, inform experiment design and fuel development of computational off-target prediction algorithms.
Critical couplings in topological-insulator waveguide-resonator systems observed in elastic waves
Authors: Yu Si-Yuan , He Cheng , Sun Xiao-Chen , Wang Hong-Fei , Wang Ji-Qian , Zhang Zi-Dong , Xie Bi-Ye , Tian Yuan , Lu Ming-Hui , Chen Yan-Feng 
Published: October 2020

Abstract
Waveguides and resonators are core components in the large-scale integration of electronics, photonics and phononics, both in existing and future scenarios. In certain situations, there is critical coupling of the two components; i.e. no energy passes through the waveguide after the incoming wave couples into the resonator. The transmission spectral characteristics resulting from this phenomenon are highly advantageous for signal filtering, switching, multiplexing and sensing. In the present study, adopting an elastic-wave platform, we introduce topological insulator (TI), a remarkable achievement in condensed matter physics over the past decade, into a classical waveguide-ring-resonator configuration. Along with basic similarities with classical systems, a TI system has important differences and advantages, mostly owing to the spin-momentum locked transmission states at the TI boundaries. As an example, a two-port TI waveguide resonator can fundamentally eliminate upstream reflections while completely retaining useful transmission spectral characteristics, and maximize the energy in the resonator, with possible applications being novel signal processing, gyro/sensing, lasering, energy harvesting and intense wave–matter interactions, using phonons, photons or even electrons. The present work further enhances confidence in using topological protection for practical device performance and functionalities, especially considering the crucial advantage of introducing (pseudo)spins to existing conventional configurations. More in-depth research on advancing phononics/photonics, especially on-chip, is foreseen.
Evolution of Drug Interactions With Antiretroviral Medication in People With HIV
Authors: El Moussaoui Majdouline , Lambert Iseult , Maes Nathalie , Sauvage Anne-Sophie , Frippiat Frédéric , Meuris Christelle , Uurlings Françoise , Lecomte Marianne , Léonard Philippe , Fombellida Karine , Vaira Dolores , Vercheval Christelle , Moutschen Michel , Darcis Gilles 
Published: October 2020

Abstract

Background
Polypharmacy and drug interactions are important issues for HIV-infected individuals. The number and nature of those interactions are continuously evolving with the use of new antiretroviral drugs and the aging of HIV-infected individuals. We aimed to analyze this evolution over time.

Methods
This retrospective cohort study was conducted in the University Hospital of Liège (Belgium). Treatments of HIV-infected outpatients attending Liège University Hospital were collected and analyzed in 2012 and 2016. The University of Liverpool HIV drug interactions database was used to determine drug interactions.

Results
We included 1038 patients in 2016, of whom 78% had 1 comedication. Polypharmacy was seen in 20% of the cohort. Four percent of the patients presented red flag interactions, and 38% had orange flag interactions. Nonantiretroviral (non-ARV) therapeutic classes involved in drug interactions were mostly cardiovascular and central nervous system drugs. They were followed by hormone drugs and dietary supplements for orange flag interactions. Two factors significantly contributed to both red and orange flag interactions: the number of non-ARV comedications and protease inhibitor–based ARV regimens. The proportion of patients with red or orange flag interactions remained stable from 2012 to 2016.

Conclusions
This study highlights the persistence of an alarming number of contraindicated drug interactions and a high prevalence of potential drug interactions over time. Identification, prevention, and management of drug interactions remain a key priority in HIV care.
Global Seasonality of Human Coronaviruses: A Systematic Review
Authors: Park Sangshin , Lee Yeonjin , Michelow Ian C , Choe Young June 
Published: October 2020

Abstract
In the context of the coronavirus disease 2019 pandemic, we aimed to systematically address the global seasonal patterns of human coronavirus (HCoV) infections. We identified relevant articles from MEDLINE, EMBASE, and CINAHL Plus as of May 11, 2020. The main outcomes were the peak months of HCoV infections each year and the months during which more than 5% of positive respiratory specimen tests were attributable to HCoV. Of 707 articles reviewed, 22 met the inclusion criteria. The annual percentage of HCoV infections reached a peak in February globally. We found a higher HCoV positivity rate among studies that tested only children (median: 5.9%, range: 0.9%–18.4%), compared with other studies of adults alone (median: 5.2%, range: 3.3%–7.1%) or the entire population (median: 1.9%, range: 0.2%–8.1%). We found the largest global peak of HCoV during the winter season, with the highest rate of positivity among children.
Cerebrospinal Analysis in Patients With COVID-19
Authors: Miller Emily Happy , Namale Vivian S , Kim Carla , Dugue Rachelle , Waldrop Greer , Ciryam Prajwal , Chong Alexander M , Zucker Jason , Miller Eliza C , Bain Jennifer M , Willey Joshua Z , Doyle Kevin , Boehme Amelia , Claassen Jan , Uhlemann Anne-Catrin , Thakur Kiran T 
Published: October 2020

Abstract

Background
Assessment of the impact of cerebrospinal fluid (CSF) analysis including investigation for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the optimization of patient care.

Methods
In this case series, we review patients diagnosed with SARS-CoV-2 undergoing lumbar puncture (LP) admitted to Columbia University Irving Medical Center (New York, NY, USA) from March 1 to May 26, 2020. In a subset of patients, CSF SARS-CoV-2 quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) testing is performed.

Results
The average age of 27 patients who underwent LP with definitive SARS-CoV-2 (SD) was 37.5 (28.7) years. CSF profiles showed elevated white blood cell counts and protein in 44% and 52% of patients, respectively. LP results impacted treatment decisions in 10 (37%) patients, either by change of antibiotics, influence in disposition decision, or by providing an alternative diagnosis. CSF SARS-CoV-2 qRT-PCR was performed on 8 (30%) patients, with negative results in all samples.

Conclusions
Among patients diagnosed with SARS-CoV-2, CSF results changed treatment decisions or disposition in over one-third of our patient cohort. CSF was frequently abnormal, though CSF SARS-CoV-2 qRT-PCR was negative in all samples. Further studies are required to define whether CSF SARS-CoV-2 testing is warranted in certain clinical contexts.
Physiological Characteristic Changes and Full-Length Transcriptome of Rose (Rosa chinensis) Roots and Leaves in Response to Drought Stress
Authors: Li Wei , Fu Lufeng , Geng Ziwen , Zhao Xiaojuan , Liu Qinghua , Jiang Xinqiang 
Published: October 2020

Abstract
Rose (Rosa chinensis) is the most important ornamental crops worldwide. However, the physiological and molecular mechanism of rose under drought stress remains elusive. In this study, we analyzed the changes of photosynthetic and phytohormone levels in the leaves and roots of rose seedlings grown under control (no drought), mild drought (MD) and severe drought stress. The total chlorophyll content and water use efficiency were significantly enhanced under MD in rose leaves. In addition, the concentration of ABA was higher in the leaves compared to the roots, whereas the roots accumulated more IAA, methylindole-3-acetic acid and indole-3-propionic acid. We also constructed the first full-length transcriptome for rose, and identified 96,201,862 full-length reads of average length 1,149 bp that included 65,789 novel transcripts. A total of 3,657 and 4,341 differentially expressed genes (DEGs) were identified in rose leaves and roots respectively. KEGG pathway analysis showed enrichment of plant hormone, signal transduction and photosynthesis are among the DEGs. 42,544 alternatively spliced isoforms were also identified, and alternative 3′ splice site was the major alternative splicing (AS) event among the DEGs. Variations in the AS patterns of three genes between leaves and roots indicated the possibility of tissue-specific posttranscriptional regulation in response to drought stress. Furthermore, 2,410 novel long non-coding RNAs were detected that may participate in regulating the drought-induced DEGs. Our findings identified previously unknown splice sites and new genes in the rose transcriptome, and elucidated the drought stress-responsive genes as well as their intricate regulatory networks.