bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic accuracy of perinatal post-mortem ultrasound (PMUS): a systematic review
Authors: Shelmerdine Susan , Langan Dean , Sebire Neil J , Arthurs Owen 
Published: November 2019

ObjectiveUltrasound is ubiquitous in live paediatric imaging; however, its usage in post-mortem setting is less established. This systematic review aims to evaluate the diagnostic accuracy of paediatric post-mortem ultrasound (PMUS).DesignMEDLINE, Embase and Cochrane Library databases were queried for studies published between 1998 and 2018 assessing PMUS diagnostic accuracy rates in children<18 years old, using autopsy as reference standard. Risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies 2. A bivariate random-effects model was used to obtain combined mean estimates of sensitivity and specificity for different body systems.ResultsFour studies were included, all relating to ultrasound for perinatal deaths. The mean diagnostic sensitivity and specificity for neurological abnormalities were 84.3% (95% CI: 70.8% to 92.2%) and 96.7% (95% CI: 86.5% to 99.3%); for cardiothoracic abnormalities 52.1% (95% CI: 27.6% to 75.5%,) and 96.6% (95% CI: 86.8% to 99.2%); and for abdominal abnormalities 78.4% (95% CI: 61.0% to 89.4%) and 97.3% (95% CI: 88.9% to 99.4%). Combining all body systems, the mean sensitivity and specificity were 73.3% (95% CI: 59.9% to 83.5%) and 96.6% (95% CI: 92.6% to 98.4%).ConclusionsPMUS demonstrates a reasonable diagnostic accuracy, particularly for abdominal and neurological abnormalities, although cardiac anomalies were less readily identified.Trial registration numberCRD42018106968.
Inclusion of older patients with cancer in randomised controlled trials with patient-reported outcomes: a systematic review
Authors: Sparano Francesco , Aaronson Neil K , Sprangers Mirjam A G , Fayers Peter , Pusic Andrea , Kieffer Jacobien M , Cottone Francesco , Rees Jonathan , Pezold Mike , Anota Amelie , Charton Emilie , Vignetti Marco , Wan Chonghua , Blazeby Jane , Efficace Fabio 
Published: November 2019

ObjectivesInclusion of patient-reported outcomes (PROs) in cancer randomised controlled trials (RCTs) may be particularly important for older patients. The objectives of this systematic review were to quantify the frequency with which older patients are included in RCTs with PROs and to evaluate the quality of PRO reporting in those trials.MethodsAll RCTs with PRO endpoints, published between January 2004 and February 2019, which included a patient sample with a mean/median age ≥70 years, were considered for this systematic review. The following cancer malignancies were considered: breast, colorectal, lung, prostate, gynaecological and bladder cancer.Quality of PRO reporting was evaluated using the International Society for Quality of Life Research–PRO standards. Studies meeting at least two-thirds of these criteria were considered to have high-quality PRO reporting.ResultsOf 649 RCTs identified with a PRO endpoint, only 72 (11.1%) included older patients. Of these, 35 trials (48.6%) were conducted in patients with metastatic/advanced disease. PROs were primary endpoints in 20 RCTs (27.8%). Overall survival was the most frequently reported clinical outcome in studies of patients with metastatic/advanced cancer (n=28, 80%). One-third of the RCTs (n=24, 33.3%) were considered to have high-quality PRO reporting. Overall, the largest prevalence of RCTs with high-quality PRO reporting was observed in prostate and colorectal cancers.ConclusionsOur review indicates not only that PRO–RCT-based studies in oncology rarely include older patients but also that completeness of PRO reporting of many of them is often suboptimal.
No excess harms from sustained-release morphine: a randomised placebo-controlled trial in chronic breathlessness
Authors: Johnson Miriam J , Sbizzera Illary , Fairhurst Caroline , Fazekas Belinda , Agar Meera , Ekstrom Magnus , Currow David C 
Published: November 2019

ObjectivesWe aimed to identify and evaluate: (1) treatment-emergent adverse events (TEAE (worse or new since baseline)) and the subgroup of severe TEAEs in a placebo-controlled 7-day randomised trial of regular, low-dose, sustained-release oral morphine for chronic breathlessness and (2) clinical characteristics associated with TEAE.MethodsSafety analysis of trial data. Adults with chronic breathlessness (modified Medical Research Council breathlessness score ≥2) due to heart or lung disease, or cancer, not on regular opioids were eligible. Symptoms associated with opioids (TEAE of special interest) were systematically sought using Common Terminology Criteria for Adverse Events (CTCAE) grading. Other harms could be reported at any time. The relationship between characteristics and presence of ≥1 TEAE of special interest was explored using univariable logistic regression analyses.Results1449/5624 (26%) Adverse Events from 279 participants were TEAE of which 150/1449 (10%) were severe (CTCAE grades 3–5). 1086/5624 (75%) were events of special interest of which 41/1086 (4%) were severe. Compared with placebo, morphine was not associated with more TEAE or severe TEAE of special interest (TEAE: OR 0.53, 95% CI 0.21 to 1.38, p=0.20; severe TEAE: OR 0.96, 95% CI 0.27 to 3.41, p=0.95) nor with CTCAE severity grade (χ2=4.39, p=0.50). Among the 26/150 (17%) with severe TEAEs, study withdrawal was more common in the morphine arm (18/26 (69%) morphine arm; 8/26 (30%) placebo arm). None of the severe TEAEs was a respiratory harm.ConclusionsSevere morphine-associated toxicity was uncommon and not associated with study arm. Clinical consequences were minor and self-limiting.Trial registration numberACTRN126000806268.
Factors influencing physician risk estimates for acute cardiac events in emergency patients with suspected acute coronary syndrome
Authors: Greenslade Jaimi H , Sieben Nicolas , Parsonage William A , Knowlman Thomas , Ruane Lorcan , Than Martin , Pickering John W , Hawkins Tracey , Cullen Louise 
Published: November 2019

BackgroundEmergency physicians frequently assess risk of acute cardiac events (ACEs) in patients with undifferentiated chest pain. Such estimates have been shown to have moderate to high sensitivity for ACE but are conservative. Little is known about the factors implicitly used by physicians to determine the pretest probability of risk. This study sought to identify the accuracy of physician risk estimates for ACE in patients presenting to the ED with chest pain and to identify the demographic and clinical information emergency physicians use in their determination of patient risk.MethodsThis study used data from two prospective studies of consenting adult patients presenting to the ED with symptoms of possible acute coronary syndrome. ED physicians estimated the pretest probability of ACE. Multiple linear regression analysis was used to identify predictors of physician risk estimates. Logistic regression was used to determine whether there was a correlation between physicians’ estimated risk and ACE.ResultsIncreasing age, male sex, abnormal ECG features, heavy/crushing chest pain and risk factors were correlated with physician risk estimates. Physician risk estimates were consistently found to be higher than the expected proportion of ACE from the sampled population.ConclusionPhysicians systematically overestimate ACE risk. A range of factors are associated with physician risk estimates. These include factors strongly predictive of ACE, such as age and ECG characteristics. They also include other factors that have been shown to be unreliable predictors of ACE in an ED setting, such as typicality of pain and risk factors.
Formation and tribological properties of MoS2 self-lubricating porous anodic alumina thin flims
Authors: Han Dengquan , Wang Yao , Li Yuanxing , Li Xiaoya , Zhu Zongtao , Shi Xin , Qiu Sifu 
Published: November 2019

MoS2 self-lubricating films were prepared on long-range ordered porous anodic alumina (PAA) by an electrophoretic deposition (EPD) method. The PAA was prepared by two-step anodization of aluminum plates. Oxalic-acid-based electrolytes were used in the first step and phosphoric-acid-based electrolytes were used in the second step. This process offers a new approach to preparing PAA with wide adjustable boundary distances (43.5–21 nm) by increasing the voltage from 80 V to 100 V. The boundary distances were decreased from 78 nm to 42.2 nm by increasing the solution concentration, which increased the interpore distance. The coefficient of friction and hard-wearing of the MoS2 lubrication film on the PAA were studied by a ball-on-disk friction and wear tester. The results showed that the nanotubes stored MoS2 particles, which provided continuous lubrication.
Archaeomagnetic knowledge of the Neolithic in Bulgaria with emphasis on intensity changes
Authors: Kostadinova-Avramova Maria , Kovacheva Mary , Boyadzhiev Yavor , Hervé Gwenaël 
Published: November 2019

Abstract
Several archaeological baked clay structures from Bulgarian Neolithic sites were archaeomagnetically studied. According to the ancient firing conditions, the collected materials are dwelling remains and ovens with different heating histories. The variability of magnetic properties is greater in the burnt dwelling remains compared to the ovens. The prevailing magnetic minerals are magnetite/titanomagnetite and epsilon iron oxide. Less often, the presence of hematite is suggested. For one of the ovens, a well-pronounced evolution in magnetic properties was observed between its successive levels. The collected materials possess stable magnetic mineralogy and the success rate of archaeointensity determination experiment is 84%. The experiment completely failed only for the structure where epsilon iron oxide is not identified and where the lowest median destructive fields are determined.
The obtained archaeomagnetic results are summarized as 10 new reference points. The structures subjected to the same firing event are combined as one feature. Their dating is based on well-established relative Neolithic chronology and stratigraphic constraints. The new data coincide fairly well with the Bulgarian dataset and with the data available for the neighbouring countries, confirming an intensity maximum around 5550 BC and a minimum around 5400 BC. No indications of geomagnetic ‘spikes’ or ‘jerks’ are detected.
Palaeosecular variations of the geomagnetic field in Africa during the Holocene: a review
Authors: Di Chiara Anita 
Published: November 2019

Abstract
The importance of the full understanding of the Holocene geomagnetic field spans from human history and archaeology, to palaeoclimatic changes and engineering, to geomagnetic field modelling and unravelling of the geomagnetic field characteristics and anomalies. Unfortunately, the dearth of data from large under-covered areas such as oceans, the African and South American continents, and the southern hemisphere (only 4–6% of the global datasets) dramatically limits our knowledge of the temporal and spatial evolution of the geomagnetic field and its application. Here, a review of all data from the African continent is presented in order to encourage and motivate a new generation of palaeomagnetic and archaeomagnetic studies. New data will sharpen the palaeomagnetism as a dating tool, improve our knowledge of local/global geomagnetic features, and will help to finally answer some of the fundamental questions in palaeomagnetism, like the temporal and spatial distribution of the palaeointensity peaks described, and the origin and evolution of the South Atlantic Anomaly.
Photodynamic Therapy Is an Effective Adjuvant Therapy for Image-Guided Surgery in Prostate Cancer
Authors: Wang Xinning , Ramamurthy Gopolakrishnan , Shirke Aditi A. , Walker Ethan , Mangadlao Joey , Wang Ziying , Wang Yu , Shan Lingpeng , Schluchter Mark D. , Dong Zhipeng , Brady-Kalnay Susann M. , Walker Natalie K. , Gargesha Madhusudhana , MacLennan Gregory , Luo Dong , Sun Rongcan , Scott Bryan , Roy Debashish , Li Jing , Basilion James P. 
Published: November 2019

Abstract

Local and metastatic relapses of prostate cancer often occur following attempted curative resection of the primary tumor, and up to 66% of local recurrences are associated with positive margins. Therefore, technologies that can improve the visualization of tumor margins and adjuvant therapies to ablate remaining tumor tissues are needed during surgical resection of prostate adenocarcinoma. Photodynamic agents have the potential to combine both fluorescence for image-guided surgery (IGS) and photodynamic therapy (PDT) to resect and ablate cancer cells. The objective of this study was to determine the utility of a targeted PDT agent for IGS and adjuvant PDT. Using a previously developed prostate-specific membrane antigen (PSMA)–targeted PDT agent, PSMA-1-Pc413, we showed that PSMA-1-Pc413 selectively highlighted PSMA-expressing tumors, allowing IGS and more complete tumor resection compared with white light surgery. Subsequent PDT further reduced tumor recurrence and extended animal survival significantly. This approach also enabled identification of tumor cells in lymph nodes. In summary, this study presents a potential new treatment option for patients with prostate cancer undergoing surgery, which improves tumor visualization and discrimination during surgery, including identification of cancer in lymph nodes.

Significance:
These findings present a photodynamic agent that can be used for both photodynamic therapy and image-guided surgery, allowing better visualization of tumor margins and elimination of residual tumor tissues.
Penetrance of Different Cancer Types in Families with Li-Fraumeni Syndrome: A Validation Study Using Multicenter Cohorts
Authors: Shin Seung Jun , Dodd-Eaton Elissa B. , Peng Gang , Bojadzieva Jasmina , Chen Jingxiao , Amos Christopher I. , Frone Megan N. , Khincha Payal P. , Mai Phuong L. , Savage Sharon A. , Ballinger Mandy L. , Thomas David M. , Yuan Ying , Strong Louise C. , Wang Wenyi 
Published: November 2019

Abstract

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal-dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capable of estimating the risk of an individual being a TP53 mutation carrier. However, an accurate estimation of the penetrance of different cancer types in LFS is crucial to improve the clinical characterization and management of high-risk individuals. Here, we developed a competing risk-based statistical model that incorporates the pedigree structure efficiently into the penetrance estimation and corrects for ascertainment bias while also increasing the effective sample size of this rare population. This enabled successful estimation of TP53 penetrance for three LFS cancer types: breast (BR), sarcoma (SA), and others (OT), from 186 pediatric sarcoma families collected at MD Anderson Cancer Center (Houston, TX). Penetrance validation was performed on a combined dataset of two clinically ascertained family cohorts with cancer to overcome internal bias in each (total number of families = 668). The age-dependent onset probability distributions of specific cancer types were different. For breast cancer, the TP53 penetrance went up at an earlier age than the reported BRCA1/2 penetrance. The prediction performance of the penetrance estimates was validated by the combined independent cohorts (BR = 85, SA = 540, and OT = 158). Area under the ROC curves (AUC) were 0.92 (BR), 0.75 (SA), and 0.81 (OT). The new penetrance estimates have been incorporated into the current LFSPRO R package to provide risk estimates for the diagnosis of breast cancer, sarcoma, or other cancers.

Significance:
These findings provide specific penetrance estimates for LFS-associated cancers, which will likely impact the management of families at high risk of LFS.
See related article by Shin et al., p. 347
Changes in CT Radiomic Features Associated with Lymphocyte Distribution Predict Overall Survival and Response to Immunotherapy in Non–Small Cell Lung Cancer
Authors: Khorrami Mohammadhadi , Prasanna Prateek , Gupta Amit , Patil Pradnya , Velu Priya D. , Thawani Rajat , Corredor German , Alilou Mehdi , Bera Kaustav , Fu Pingfu , Feldman Michael , Velcheti Vamsidhar , Madabhushi Anant 
Published: November 2019

Abstract
No predictive biomarkers can robustly identify patients with non–small cell lung cancer (NSCLC) who will benefit from immune checkpoint inhibitor (ICI) therapies. Here, in a machine learning setting, we compared changes (“delta”) in the radiomic texture (DelRADx) of CT patterns both within and outside tumor nodules before and after two to three cycles of ICI therapy. We found that DelRADx patterns could predict response to ICI therapy and overall survival (OS) for patients with NSCLC. We retrospectively analyzed data acquired from 139 patients with NSCLC at two institutions, who were divided into a discovery set (D1 = 50) and two independent validation sets (D2 = 62, D3 = 27). Intranodular and perinodular texture descriptors were extracted, and the relative differences were computed. A linear discriminant analysis (LDA) classifier was trained with 8 DelRADx features to predict RECIST-derived response. Association of delta-radiomic risk score (DRS) with OS was determined. The association of DelRADx features with tumor-infiltrating lymphocyte (TIL) density on the diagnostic biopsies (n = 36) was also evaluated. The LDA classifier yielded an AUC of 0.88 ± 0.08 in distinguishing responders from nonresponders in D1, and 0.85 and 0.81 in D2 and D3. DRS was associated with OS [HR: 1.64; 95% confidence interval (CI), 1.22–2.21; P = 0.0011; C-index = 0.72). Peritumoral Gabor features were associated with the density of TILs on diagnostic biopsy samples. Our results show that DelRADx could be used to identify early functional responses in patients with NSCLC.
<strong>The polychaete community of the Fregene artificial reef (Tyrrhenian Sea, Italy): a 20-year study (1981–2001)</strong>
Authors: Marzialetti Sara , Nicoletti Luisa , Ardizzone Gian Domenico 
Published: November 2019

The artificial reef of Fregene, Italy, was built in 1981 as a multipurpose structure with the intent of protecting the coastal environment from illegal trawling and also improving fishery production. It is located at 10–14 m depth on a sandy-silty seabed in the Tyrrhenian Sea, 5 nmi north of the outlet of the Tevere River (Latium, Italy) and 1.5 nmi offshore the town of Fregene (Latium, Italy). The development of the polychaete community on the reef was studied from May 1981 to December 2001 in order to examine long-term community dynamics and verify to what extent changes in polychaete assemblage could depict the development of the benthic assemblage. At each sampling time, two standard surfaces of 400 cm2 were scraped from the vertical walls of the same block. Temporal changes in the development of the polychaete community were detected by univariate (S, N, ExpH', 1/Simpson, J') and multivariate (CLUSTER, nMDS) analysis of the faunal data. Functional structure of the community was also analyzed. Changes in the community structure were shown by an overall increasing trend in the total number of species and individuals. The 20-year development of the polychaete community was divided into five different phases representing different benthic assemblages on the reef: the first two periods correspond to settlement of pioneer species (1981–82); the third is a phase characterized by Mytilus galloprovincialis dominance and regression (1983–85); the fourth is a phase of mud accumulation between dead balanids, with the presence of laminar bryozoans (1991–92), and the last corresponds to a phase dominated by bryozoan bioconstruction (2001). The increased complexity in the benthic assemblage and substratum on the reef is also shown by an increased differentiation and distribution of polychaete functional groups. Increasing environmental heterogeneity on the reef is the basic factor that affected biodiversity by generating new niches that could be occupied by additional species with different ecology. The similarity of the benthic assemblage observed on the reef in 2001 with natural bioconstructions suggest that after two decades the ecological succession has lead to a settlement at a steady-state of equilibrium with the surrounding environment.
<p class="HeadingRunIn"><strong>Distribution of <em>Magelona</em> species (Polychaeta: Magelonidae) in the German Bight (North Sea): a modeling approach</strong></p>
Authors: Meißner Karin , Darr Alexander 
Published: November 2019

The aim of the present study was the development of species-habitat models for four Magelona species (Polychaeta: Magelonidae) found in the German Bight in the SE North Sea. Analyses were based on field data and data obtained from reexamination of material deposited in museum collections. In addition, data on environmental variables were retrieved from the sediment map by Figge (1981) and from long-term monitoring data sets. The statistical modeling technique applied was multivariate adaptive regression splines (MARS). Predictive accuracy measures were calculated for each model. The candidate model with highest discriminatory power was selected for predictive mapping. Models with excellent predictive performance were developed for Magelona johnstoni, M. filiformis and M. alleni based on the analyzed set of environmental predictors. In each of the developed habitat models the most important predictor was a sediment parameter, either median grain size diameter (M. johnstoni) or mud content (M. alleni, M. filiformis). Salinity and water depth were also of importance. Model predictions were aimed to allow evaluation of habitat suitability for the investigated species in the German Bight. According to our results suitable habitats for M. johnstoni are numerous and a wide distribution of this species could be expected. Habitat suitability for M. filiformis in the German Bight was suggested to be high in areas with mud contents below 10 % at water depths between 25 and 35 m. The M. alleni habitat model indicated the presence of suitable habitats where sands with elevated mud contents are present and where water depths exceed 30 m.
<strong>Trichoptera from the Great Falls and Turkey Run units of the George Washington Memorial Parkway, Fairfax Co., Virginia, USA</strong>
Authors: FLINT JR. OLIVER S. 
Published: November 2019

A 3-year effort to collect and identify caddisflies (Trichoptera) along 2 sections of the Potomac River was undertaken at the request of the National Park Service. A variety of techniques including Malaise traps, light traps, and hand netting resulted in the collection of 105 species belonging to 17 families and 38 genera. Fifty-seven species or 54% were deemed rare, 20 species or 19% were common and 28 species or 27% were abundant. Comments are made on 7 species of special interest. An addendum lists 6 additional species collected during the 4th year’s survey.
Interventions for Attitudes and Empathy Toward People With Dementia and Positive Aspects of Caregiving: A Systematic Review and Meta-Analysis
Authors: Han Areum 
Published: November 2019

Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) examined the effect of interventions on three outcomes among caregivers of people with dementia and health professionals, including positive aspects of caregiving, attitudes toward people with dementia, and empathy. Methods: Three electronic databases were searched to find RCTs published in peer-reviewed journals until January 7, 2019. A total of 13 studies met the eligibility criteria and were included in meta-analysis. Results: The included studies compared psychoeducational interventions, a combination of education, skill-building, and coping strategies, to control group. Meta-analyses of the included studies found that the overall effects of psychoeducational interventions on three outcomes were not statistically significant compared to control groups. Conclusions: The findings indicate that there is no evidence for the positive effect of psychoeducational interventions on these outcomes, warranting further RCT studies designed to target on these outcomes.