bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD4+ T‐cell Transcription Factors in Idiopathic REM Sleep Behavior Disorder and Parkinson's Disease
Authors: De Francesco Erika , Terzaghi Michele , Storelli Elisa , Magistrelli Luca , Comi Cristoforo , Legnaro Massimiliano , Mauri Marco , Marino Franca , Versino Maurizio , Cosentino Marco 
Published: July 2020

AbstractBackgroundCD4+ T‐cell dysregulation occurs in Parkinson's disease (PD); however, it is unknown whether it contributes to PD development. The objective of this study was to investigate transcription factor gene expression in CD4+ T cells in idiopathic rapid eye movement sleep behavior disorder, the strongest risk factor for prodromal PD.MethodsExpression of transcription factors (TBX21, STAT1, STAT3, STAT4, STAT6, RORC, GATA3, FOXP3, and NR4A2) was measured in CD4+ T cells from 33 polysomnographically confirmed idiopathic rapid eye movement sleep behavior disorder subjects and compared with expression in cells from matched healthy subjects and antiparkinson drugs‐naive PD patients.ResultsCompared with healthy subjects, idiopathic rapid eye movement sleep behavior disorder subjects and PD patients had lower TBX21, STAT3, and STAT4, and higher FOXP3 expression. TBX21 expression discriminated healthy subjects from idiopathic rapid eye movement sleep behavior disorder subjects and PD patients, but not idiopathic rapid eye movement sleep behavior disorder subjects with PD.ConclusionsIn idiopathic rapid eye movement sleep behavior disorder subjects CD4+ T cells exhibit a peculiar molecular signature strongly resembling cells from PD patients, suggesting early involvement of peripheral immunity in PD. © 2020 International Parkinson and Movement Disorder Society
CD14/16 monocyte profiling in juvenile myelomonocytic leukemia
Authors: Gadgeel Manisha , Bagla Shruti , Buck Steven , Shamoun Mark , Ravindranath Yaddanapudi 
Published: July 2020

AbstractMonocyte subset analysis by flow cytometry has been shown to be a useful diagnostic tool in chronic myelomonocytic leukemia in adults. An increase in the classical monocyte fraction (CD14++/CD16−) greater than 94.0% of total monocytes is considered highly sensitive and specific in distinguishing chronic myelomonocytic leukemia from other myeloproliferative disorders. In a pilot study of juvenile myelomonocytic leukemia cases, we noted that CD14++/CD16− monocyte fraction was >95% in de novo juvenile myelomonocytic leukemia (JMML) with somatic PTPN11 mutations but normal in those with monosomy 7 or Noonan syndrome. Monocyte subgroup profiling by itself is not diagnostic of JMML but may distinguish molecular subgroups within JMML.
Random poly(ε‐caprolactone‐L‐alanine) by direct melt copolymerization
Authors: Salhi Slim , Mahfoudh Jihen , Abid Souhir , Atanase Leonard‐Ionut , Popa Marcel , Delaite Christelle 
Published: July 2020

AbstractA series of random polyesteramides (PEAs) with a range of molar composition from 90/10 to 50/50 were synthesized by direct melt polycondensation of ε‐caprolactone and l‐alanine. Their structure was fully characterized by Fourier transform IR and NMR spectroscopy. The resulting copolymers are completely amorphous with the exception of PEA‐90/10 which possesses a semicrystalline structure. These PEAs present increasing glass transition temperatures at increasing l‐alanine contents and exhibit fairly good thermal stability with 10% mass loss temperatures reaching 315 °C. © 2020 Society of Industrial Chemistry
Cherry damage and the spatial distribution of European earwigs, (Forficula auricularia L.) in sweet cherry trees
Authors: Quarrell Stephen R , Corkrey Ross , Allen Geoff R 
Published: July 2020

AbstractBACKGROUNDThe European earwig, Forficula auricularia is an invasive insect pest found in many temperate regions of the world. Despite being well known predators, earwigs are considered pests in sweet cherry though this has never been empirically tested. Our aim was to quantify the relationship between damaged cherry fruit and earwig population size, cherry bunch size and earwig distribution in cherry tree canopies in the cherry varieties Ron's Seedling, Lewis, Sweet Georgia, and Lapin.RESULTSSignificant differences in earwig damage type and frequency were observed between varieties with earwig exclusion significantly reducing damage by 21% in Lapin and 34% in Ron's Seedling. Earwigs were strongly aggregated within cherry bunches, with greater numbers and damage observed in larger bunch sizes in all varieties except Ron's Seedling where stem damage was independent of bunch size. In Ron's Seedling, cherry stems were 40× more likely to be damaged than Lewis stems and Lewis fruit two times more likely to be damaged than Ron's Seedling fruit. Sweet Georgia fruit were 4.5 times and stems five times more likely to be damaged than in Lapin. No predictive relationship between cherry damage levels and earwig numbers either within the tree canopies or within monitoring traps could be determined.CONCLUSIONEuropean earwigs may have a significant economic impact to sweet cherry production. The nature of this impact differs between cherry varieties and severity is strongly influenced by factors including bunch size. However, why damage differs between varieties remains unknown and warrants further investigation if the impact of earwigs to sweet cherry production is to be minimized.
Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection
Authors: Keam Synat , Megawati Dewi , Patel Shailesh Kumar , Tiwari Ruchi , Dhama Kuldeep , Harapan Harapan 
Published: July 2020

SummaryThe outbreak of coronavirus disease 2019 (COVID‐19) and pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a major concern globally. As of 14 April 2020, more than 1.9 million COVID‐19 cases have been reported in 185 countries. Some patients with COVID‐19 develop severe clinical manifestations, while others show mild symptoms, suggesting that dysregulation of the host immune response contributes to disease progression and severity. In this review, we have summarized and discussed recent immunological studies focusing on the response of the host immune system and the immunopathology of SARS‐CoV‐2 infection as well as immunotherapeutic strategies for COVID‐19. Immune evasion by SARS‐CoV‐2, functional exhaustion of lymphocytes, and cytokine storm have been discussed as part of immunopathology mechanisms in SARS‐CoV‐2 infection. Some potential immunotherapeutic strategies to control the progression of COVID‐19, such as passive antibody therapy and use of interferon αβ and IL‐6 receptor (IL‐6R) inhibitor, have also been discussed. This may help us to understand the immune status of patients with COVID‐19, particularly those with severe clinical presentation, and form a basis for further immunotherapeutic investigations.
GLOB: A global project management readiness framework
Authors: Niazi Mahmood , Mahmood Sajjad , Alshayeb Mohammad 
Published: July 2020

AbstractIn global software development (GSD), software is developed by a team of geographically dispersed people. Many organizations that develop projects globally do not evaluate their project management readiness to undertake such projects.The objective of this paper is to propose a global project management readiness framework (GLOB) to help organizations in evaluating and assessing their GSD project management readiness to improve their capabilities in managing GSD projects.To develop GLOB, three systematic literature reviews (SLRs) were conducted. For each SLR, an empirical study was conducted with GSD practitioners to validate the SLR results in a real‐world environment.We identified 45 factors that can play a positive or negative role in global project management readiness. In total, 305 best practices were identified for global project management. Based on the findings of the SLRs and empirical studies, GLOB was developed. Two case studies were conducted to evaluate GLOB in a real‐world context. The case study results show that GLOB has the potential to measure an organization's project management readiness for global projects.It is hoped that GLOB will provide GSD practitioners with the ability to understand the strengths and weaknesses of current project management processes and to address weak areas.
Quantitative method for determination of 3,3‐dimethylallyl bromide genotoxic impurity in Tazarotene drug substance by GC‐MS
Authors: Rajana Nagaraju , Ramana D.V , Moses Babu J. , Basavaiah K. , Rama Devi Dharamasoth 
Published: July 2020

AbstractA highly sensitive gas chromatography‐mass spectrometry quantitative method was developed for 3,3‐dimethylallyl bromide genotoxic impurity in the tazarotene drug substance. The method was validated by following the International conference for harmonization Q2 (R1) guideline for the limit test of 3,3‐dimethylallyl bromide genotoxic impurity in the tazarotene drug substance. The 148 m/z, 150 m/z, and 69 m/z ions were selected to get a response in mass spectrometry for 3,3‐dimethylallyl bromide. DB‐1 (30 mm × 0.25 × 1.0 µm) column was used for the separation of 3,3‐dimethylallyl bromide from the sample matrix. The limit of detection and limit of quantitation for 3,3‐dimethylallyl bromide in this method was 0.7 and 2.1 ppm, respectively. The method was precise and accurate at limit of quantitation level, 1.7% RSD was observed at limit of quantitation precision and 100.9% recovery observed at limit of quantitation accuracy, it was linear from the 5 to 20 µg/L, the correlation coefficient (r) was 0.9996.
Microbiological air quality in pharmacies and an antibiotic resistance profile of staphylococci species
Authors: Jankowiak Emilia , Kubera Łukasz , Małecka-Adamowicz Marta , Dembowska Ewa 
Published: July 2020

AbstractThe air in public facilities contains microorganisms which may cause a wide variety of clinical syndromes in humans. This is particularly important in primary healthcare units, where patients with reduced immunity and staff are directly exposed to microbial pathogens. Air samples were collected from dispensing areas (customer areas) of five pharmacies using MAS-100 air sampler. The concentration of particular groups of microorganisms was determined with the use of selective media. The taxonomic analysis of mannitol-positive bacteria was conducted using the BIOLOG® method, based on metabolic characteristics of analyzed strains. The isolated molds were identified based on their macroscopic and microscopic features according to available keys. The antimicrobial susceptibility of identified staphylococci was tested using the disk diffusion method in accordance with The European Committee on Antimicrobial Susceptibility Testing recommendations. The highest average concentrations of heterotrophic bacteria and staphylococci were recorded in two hospital pharmacies. The highest average concentrations of molds were recorded in the pharmacies located in shopping centers. Taxonomic analysis indicated that Cladosporium and Penicillium spp. predominated among the isolated molds while Staphylococcus haemolyticus and Staphylococcus aureus, among mannitol-positive bacteria. Antibiograms showed that the majority of Staphylococcus strains (68.2%) were resistant to erythromycin. There was a statistically significant correlation between the concentration of investigated bacteria and the season of the year as well as the size and location of the pharmacies. The results demonstrate that there is a range of factors affecting air quality in public spaces and emphasize the fact that pharmacies can be a source of potentially pathogenic, drug-resistant bacteria.
Framework for assessing vertebrate invasive species damage: the case of feral swine in the United States
Authors: Shwiff Stephanie , Pelham Alex , Shwiff Steven , Haden-Chomphosy William , Brown Vienna R. , Ernst Karina , Anderson Aaron 
Published: July 2020

AbstractThe aim of this study is to provide a general overview of the economic impacts associated with vertebrate invasive species (VIS) in the United States and suggests a methodology for differentiating types of damage. We identify a general framework for categorizing VIS damage that separates this damage into three main categories: destruction, depredation, and disease. We then examine how this framework fits into current published estimates of damage and management costs. Economic impacts associated with feral swine damage and management are plentiful enough to warrant separate treatment from other VIS and are observed in all three categories. For all VIS examined in this study, damage estimates associated with destruction provide the most evaluations of VIS impacts, especially destruction of crops. Evaluations of the losses associated with depredation are largely absent from the literature. We find that while published studies have estimated substantial economic impact associated with VIS, the current state of the literature focusing on VIS frequently fails to address all of the categories of damage, is difficult to compare or replicate, and is unsuited for extrapolation to nation-wide estimates of damage.
Assessment of uncertainties in projecting future changes to extreme storm surge height depending on future SST and greenhouse gas concentration scenarios
Authors: Yang Jung-A , Kim Sooyoul , Son Sangyoung , Mori Nobuhito , Mase Hajime 
Published: July 2020

AbstractWe assess uncertainties in projecting future changes in extreme storm surge height (SSH) based on typhoon data extracted from ensemble experiment results with four sea surface temperature (SST) conditions and three global warming scenarios using a single atmospheric global climate model. In particular, this study focus on typhoons passing around the Korean Peninsula (KP) defined as the region of 32 to 40° N and 122 to 132° E. It is predicted the number of the typhoons affecting the KP will decrease by 4~73% while their strength will increase by 0.8~1.4% under the given future conditions. The locations of genesis and lysis of the typhoons are expected to be shifted towards the northwest and northeast for all ensemble experiment conditions, respectively. However, the extent of their change varies depending on the future SST and global warming conditions. Storm surge simulations were carried out by using predicted typhoon data as an external force. It is found that future SST patterns and climate warming scenarios affect future typhoon characteristics, which influences values of extreme SSH and locations of the vulnerable area to storm surge under the future climate conditions. In particular, the values of extreme SSH and the locations of the vulnerable area to storm surge appear to be strongly influenced by both pathway and frequency of intense typhoons.
Social Needs and Happiness: A Life Course Perspective
Authors: Buijs Vera L. , Jeronimus Bertus F. , Lodder Gerine M. A. , Steverink Nardi , de Jonge Peter 
Published: July 2020

AbstractBoth the fulfilment of affection, status, and behavioral confirmation needs and their role in happiness may differ along the adult lifespan. We examined age-graded differences in (a) the fulfilment of the need for affection, status, and behavioral confirmation, (b) disharmonious profiles of need fulfillment (e.g., high affection but low status), and (c) the associations between these needs and happiness. Data from 11,406 Dutch respondents (age range 18–87 (M = 44.82, SD = 14.62), 67% female) were collected via hoegekis.nl and categorized over six age groups (early, young, middle-aged and late adults, young-old and oldest-old). Age-graded differences in social need fulfilment and their link to happiness were examined using regression analyses. Need fulfillment profiles were identified with LCA cluster analyses. Age-graded differences in social need fulfilment were virtually absent (Cohen’s d = 0.20 or smaller) and their link with happiness was stable across the age groups. Social need fulfilment profiles were harmonious as people reported either low, middle, or high need fulfilment in general, irrespective of age. The idea that different social needs are more important in different phases of adult life received only weak support in our data. No strategic investment in specific social needs was observed (no substitution-effects).
People typically differed in their capacities to fulfil their affection, status, and behavioral confirmation needs in general, regardless of age. The implications of these results for the social production function theory of wellbeing and socioemotional selectivity theory are outlined in the discussion.
Effects of Language Skills and Strategy Use on Vocabulary Learning Through Lexical Translation and Inferencing
Authors: Alahmadi Alaa , Foltz Anouschka 
Published: July 2020

AbstractThis study explores how vocabulary learning strategy usage and skills in the four language domains relate to participants’ increase in vocabulary size and to the learning of specific vocabulary items over a certain period of time. Sixty-one advanced L1 Arabic L2 learners of English read target words in semi-authentic reading materials and were instructed to either guess the meaning from context or consult a dictionary. Pre- and delayed post-tests assessed vocabulary size and knowledge of the target vocabulary items. Results showed that learning through inferencing, but not learning through dictionary use, depended on learners’ familiarity with the particular learning strategy. Additionally, note taking and reading comprehension influenced lexical knowledge and acquisition in complex ways.
Gonadotropin-Releasing Hormone Agonists Are Effective in Long-term Treatment of Women with Abnormal Uterine Bleeding and Anticoagulant Therapy: Report of 3 Cases and Review of the Literature
Authors: Aljasser Rakia , Vilos Angelos G. , Abu-Rafea Basim , Vilos George A. 
Published: July 2020

Abstract
Purpose of Review
To evaluate the efficacy of gonadotropin-releasing hormone agonist (GnRHa) in women with abnormal uterine bleeding (AUB) on anticoagulant therapy.

Recent Findings
Prospective observational case series (Canadian Task Force Classification II-3) at University-affiliated teaching hospital. From January 2002 through December 2019, three premenopausal women on warfarin therapy were identified from our clinical practice. After clinical assessment, including Papanicolaou smear, endometrial biopsy, and pelvic sonography, a GnRHa was used to treat their AUB. Two women were receiving warfarin therapy (5–7 mg/day) for previous venous thromboembolism and one for mechanical heart valve replacement associated with Marfan’s syndrome. All patients had additional comorbid conditions and were at high risk for traditional medical or surgical therapies. After treatment with GnRHa, all women reported menstrual reduction at 3 months and remained amenorrheic for 2 to 11 years, two of whom reached menopause.

Summary
In properly assessed and selected premenopausal women with AUB receiving anticoagulant therapy and at high risk for traditional therapies, long-term GnRHa was an effective treatment in 3 patients.
Micro/atomic-scale vibration induced superlubricity
Authors: Shi Shuai , Guo Dan , Luo Jianbin 
Published: July 2020

AbstractWith the rapid development of industry, the inconsistency between the rapid increase in energy consumption and the shortage of resources is becoming significant. Friction is one of the main causes of energy consumption; thus, the emergence of superlubricity technology can substantially improve the energy efficiency in motion systems. In this study, an efficient method to control superlubricity at the atomic-scale is proposed. The method employs vibrational excitation, which is called vibration induced superlubricity (VIS). The VIS can be easily and steadily achieved by employing external vibration in three directions. The simple method does not depend on the type of sample and conductivity. Dependence of oscillation amplitude, frequency, scanning speed, and normal force (FN)on friction were investigated. Experimental and simulated explorations verified the practical approach for reducing energy dissipation and achieving superlubricity at the atomic-scale.
The Colonial/Modern [Cis]Gender System and Trans World Traveling
Authors: Leo Brooklyn 
Published: July 2020

AbstractTrans of Color inclusion is not simply a gesture of affectionate commitment to María Lugones's theory of impure communities. Rather, it is required for the enactment of her liberatory theory within and across communities of color. While María Lugones's historico-theoretical analysis of the colonial/modern gender system relies upon anthropological citations of Native gender and sexual diversity, she argues that we must bracket gender for the benefit of [cis]women of color feminisms. However, if this bracketing does not first carefully uncover cisgender histories of violence, then this decolonial feminist praxis reinscribes the invisibility of transphobia, racism, and colonialism's violent intersections, performing another mode of erasure and silence on Trans, Two-Spirit, and Nonbinary Native, Black, and Latinx peoples. In placing Lugones's texts into conversation with the voices of Two-Spirit and Trans of Color theorists, I argue that the mutilation of trans flesh makes possible the integration of [cis]People of Color into the gender–sex binary even if as failures. More important, this essay offers the beginnings of a phenomenological account of Trans World-Traveling, where the unruliness of Two-Spirit and Trans of Color bodies cocoons decolonial worlds from within the spiraling folds of abject flesh—always already in infra-communication with ancestral pasts, presents, and futures.
Probit or Logit? Which is the better model to predict the longevity of seeds?
Authors: de Faria Rute Q. , dos Santos Amanda R. P. , Amorim Deoclecio J. , Cantão Renato F. , da Silva Edvaldo A. A. , Sartori Maria M. P. 
Published: July 2020

AbstractThe prediction of seed longevity (P50) is traditionally performed by the use of the Probit model. However, due to the fact that the survival data are of binary origin (0,1), the fit of the model can be compromised by the non-normality of the residues. Consequently, this leads to prediction losses, despite the data being partially smoothed by Probit and Logit models. A possibility to reduce the effect of non-normality of the data would be to apply the principles of the central limit theorem, which states that non-normal residues tend to be normal as the n sample is increased. The Logit and Probit models differ in their normal and logistic distribution. Therefore, we developed a new estimation procedure by using a small increase of the n sample and tested it in the Probit and Logit functions to improve the prediction of P50. The results showed that the calculation of P50 by increasing the n samples from 4 to 6 replicates improved the index of correctness of the prediction. The Logit model presented better performance when compared with the Probit model, indicating that the estimation of P50 is more adequate when the adjustment of the data is performed by the Logit function.