bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using 360° Video to Enable Affective Learning in Nursing Education
Authors: Donnelly Frank , McLiesh Paul , Bessell Sally-Anne 
Published: June 2020

Background:
The affective domain describes learning associated with feelings, values, and emotions. Although this domain was first described in the late 1960s, a significant emphasis on skills and knowledge still remains. This prominence is evident despite global concerns about standards of practice and the place for empathy and care in nursing education. The emergence of newer technologies, such as 360° video, provides an opportunity to revisit the design and delivery of affective learning.

Method:
Using the taxonomy of the affective domain, a 360° video viewed through a virtual reality headset was developed to give nursing and medical students insight on the patient experience and an orientation to the operating room.

Results:
Careful planning and consideration of how the affective domain can inform design of learning and teaching materials resulted in an engaging and informative learning experience. Being aware of how each level of the domain informs the next is essential to develop effective affective teaching plans.

Conclusion:

Affective learning traditionally has been difficult to deliver and assess. Technology such as 360° video provides an engaging, reproducible, and consistent platform for delivering a domain of education.

[
J Nurs Educ
. 2020;59(7):409–412.]
O MUNDO DO TRABALHO E A PANDEMIA DE COVID-19: UM OLHAR SOBRE O SETOR INFORMAL
Authors: Isaac Silva Pedro Henrique 
Published: June 2020

A pandemia de coronavírus tem trazido enormes desafios para a economia mundial. O mundo do trabalho vem sendo duramente afetado. Seja com a perda de emprego e renda, com a introdução massiva do trabalho remoto ou com a exposição a situações de risco de contágio, trabalhadores de todo o planeta sofrem os efeitos da Covid-19, das políticas restritivas e da retração econômica. O presente artigo busca refletir sobre a relação do mundo do trabalho com a pandemia de Covid-19. Nesse sentido, analisamos os impactos da pandemia sobre os trabalhadores, especialmente aqueles que se encontram na informalidade, e as ações governamentais criadas para diminuir o impacto da crise sobre o trabalho. Por fim, trazemos a discussão sobre a criação de uma renda básica universal como política não apenas de enfrentamento da crise do coronavírus, mas também como alternativa frente à realidade de flexibilização das relações de trabalho e de vulnerabilização massificada da classe trabalhadora.
A Comprehensive Workflow for Applying Single-Cell Clustering and Pseudotime Analysis to Flow Cytometry Data
Authors: Melsen Janine E. , van Ostaijen-ten Dam Monique M. , Lankester Arjan C. , Schilham Marco W. , van den Akker Erik B. 
Published: June 2020

AbstractThe introduction of single-cell platforms inspired the development of high-dimensional single-cell analysis tools to comprehensively characterize the underlying cellular heterogeneity. Flow cytometry data are traditionally analyzed by (subjective) gating of subpopulations on two-dimensional plots. However, the increasing number of parameters measured by conventional and spectral flow cytometry reinforces the need to apply many of the recently developed tools for single-cell analysis on flow cytometry data, as well. However, the myriads of analysis options offered by the continuously released novel packages can be overwhelming to the immunologist with limited computational background. In this article, we explain the main concepts of such analyses and provide a detailed workflow to illustrate their implications and additional prerequisites when applied on flow cytometry data. Moreover, we provide readily applicable R code covering transformation, normalization, dimensionality reduction, clustering, and pseudotime analysis that can serve as a template for future analyses. We demonstrate the merit of our workflow by reanalyzing a public human dataset. Compared with standard gating, the results of our workflow provide new insights in cellular subsets, alternative classifications, and hypothetical trajectories. Taken together, we present a well-documented workflow, which utilizes existing high-dimensional single-cell analysis tools to reveal cellular heterogeneity and intercellular relationships in flow cytometry data.
Validity of International Classification of Functioning, Disability, and Health Core Set in Patients with Parkinson's Disease and the Correlation with other Parkinson Scales
Authors: Acir İbrahim , Erdoğan Hacı Ali , Yayla Vildan 
Published: June 2020

Objectives:
Idiopathic Parkinson's Disease (IPD) is a movement disorder that cause tremor, rigidity, bradykinesia, postural instability and deterioration quality of life. To assess the disease different scales can be used: The Unified Parkinson's Disease Rating Scale (UPDRS) for clinical severity, Parkinson's Disease Questionnaire (PDQ39) to assess quality of life, Beck Depression Scale (BD) for mood assessment and Hoehn Yahr Scale (HY) for clinical staging. The International Classification of Functioning, Disability and Health (ICF) is a classification to develop an international common language for the evaluation of the functionality and disability of patients. We aimed to compare validity and efficacy of ICF classification with other scales.

Materials and Methods:
Thirty-one patients with idiopathic Parkinson's disease were evaluated. PDQ39, UPDRS, Hoehn Yahr, Beck Depression Scale and 'Brief ICF core set for hand condition' which was recommended for Parkinson's disease were applied to patients. The brief ICF core set and other scales were compared and assessed if there was any correlation. For analyzes, the MedCalc Statistical Software version 12.7.7 programme was used.

Results:
The mean age of the IPD patients was 68.3 ± 6.9 years and 71% of them were female (22) and 29% were male (9). According to ICF codes, patients who have eight or more corrupted codes were recorded as 'major code impairment patients', and those with less than eight codes recorded as 'minor code impairment patients'. The total UPDRS score of major code impairment patients was 58.4 ± 29.8, while the mean score of minor code impairment patients was 21.2 ± 14.05. The PDQ39 score of major code impairment patients was 66.4 ± 24.1, while the mean score of minor code impairment patients was 19.3 ± 13.5. According to Hoehn Yahr stage, the ratio of stage 1 were higher in minor ICF patients.

Conclusion:
While assessing the functioning of the Parkinson's disease patients, we need comprehensive scales that include many parameters. The ICF coding system is an international system, which is very important to develop a common language. The significant correlation between ICF coding system and other scales in our Parkinson's patients, shows the validity of the coding system.
Reliability and Validity of the Turkish Version of King'S Parkinson's Disease Pain Scale
Authors: Soyuer Ferhan , Gültekin Murat , Cankurtaran Feyzan , Elmalı Ferhan 
Published: June 2020

Objective:
Pain, a nonmotor symptom in Parkinson's disease (PD), affects approximately 40%–85% of patients and adversely affects their daily activities. Therefore, our aim was to establish the validity and reliability of the Turkish version of King's PD Pain Scale (KPDPS) and to make it available for Turkish patients with PD patients.

Methods:
The first phase of the study involved the translation and adaptation of the KPDPS to Turkish. For the language validity of the scale, a translation back-translation method was applied, and expert's opinion was considered for content validity. In the second stage, the developed Turkish scale was administered to 152 patients with PD. In the study, test-retest was performed in 50 patients for 1 week.

Results:
The internal consistency value was found as 0.856 in the KPDPS. When the test-retest was performed, the internal consistency value of the scale showed excellent reliability. The test-retest-Cronbach's alpha value for the whole scale was 0.827. According to the data analysis results, it showed that 14 items on the scale were sufficient for the evaluation of pain in patients with PD.

Conclusion:
The results from this study show that KPDPS items have adequate internal consistency and test-retest reliability. The Turkish KPDPS can be used as a reliable and valid instrument for assessing the pain symptoms common to patients with PD.
MEIO AMBIENTE, BOTÂNICA E SOLOS: UMA RELAÇÃO FUNCIONAL PARA AULAS DE BIOLOGIA E GEOGRAFIA
Authors: Fonseca Veoso Pedro Henrique , Viana Santana Júlia Maria , Oliveira Miranda D’angelis Flávia Núbia , Araújo Lacerda Guilherme , Venuto Moura Ana Paula 
Published: June 2020

O ensino da biologia costuma ser regular de forma linear e em sala de aula, dificilmente existe a relação de ensino-aprendizagem fora da sala, em um espaço aberto onde a comunicação interpessoal se torna fluida e proveitosa, visando isso, as aulas práticas demonstrativas expositivas são uma excelente forma de trabalhar com diversos conteúdos, como é o caso da educação ambiental aplicada ao bioma da região, botânica onde o conteúdo constantemente é malvisto pela dificuldade de assimilação e a relação dos solos que faz o fechamento da absorção de água do ecossistema. O trabalho de campo auxilia na fixação das questões trabalhadas em sala de aula, estabelecendo uma relação de ensino-aprendizagem favorável ao aluno, que desfruta das atividades de uma forma mais dinâmica.
High expression of hexokinase 2 promotes lung cancer proliferation and metastasis
Authors: Zhao Yongjuan , Li Ning , Zhao Jianjun , Shi Shaomin 
Published: June 2020

IntroductionHigh metabolic plasticity, as one of the hallmarks of multiple cancers, usually promotes cancer growth and metastasis. Therefore, metabolic enzymes could be selective targets in suppressing the growth and invasion of cancer cells. It is generally believed that hexokinase 2 (HK2) catalysing glucose into glucose-6-phosphate is the first step in glucose metabolism. It is unclear, however, if HK2 is involved in lung cancer (LC) proliferation and metastasis.Material and methodsTumours and adjacent tissue from LC patients were used to study the expression of HK2 by RT-PCR and western blot analysis. Several different LC cell lines were used to explore the oncogene function of HK2 via MTS and BrdU assay in vitro, as well as xenografts model and Lung metastasis model in vivo.ResultsHK2 was upregulated in primary LC tissue and metastatic foci. The expression of HK2 can be modulated by multiple mutations of oncogenes or tumour suppressors, including Kras, p53, and Keap1. Functionally, suppression of HK2 expression by shRNA transfection in LC cell lines hindered lactate production and therefore suppressed cell migration and invasion. The depletion of HK2 also sensitised the LC cells to cisplatin-induced apoptosis, suggesting that HK2 also mediated the chemoresistance in LC. Finally, our in vivo data indicated that stable knockdown of HK2 inhibited xenografted tumour growth, sensitized the tumour response to cisplatin treatment, and decreased the incidence of lung metastasis in nude mice after tail vein injection.ConclusionsWe demonstrated that HK2 is required for LC cell growth and metastasis in vitro and in vivo, and for its relationship between multiple mutations in LC. Our results revealed that HK2 promotes LC cell proliferation and metastasis in various mutation backgrounds of LC cells, indicating that HK2 is a high-potential therapy target for LC treatment. Our data provide strong evidence that HK2 plays an important role in promoting LC disease progression, and it may be a promising target for lung cancer therapy.
In the Midst of … Words Inside-Out: Pandemic Rhetorics
Authors: Constable Marianne 
Published: June 2020

ABSTRACTIn the midst of the 2020 pandemic produced by an invisible virus, words bring the world near. Words come in from a threatening outside, even as their use turns those who are inside outward. Speech practices reconfigure work and non-work, while politics, like language, turns inside-out.
Een praktische benadering van executoriale verkoop van onroerende zaken
Authors: Burgers H.Th.M. 
Published: June 2020

Een praktische benadering van executoriale verkoop van onroerende zaken
In dit artikel worden enkele incidenten en gewoonten besproken die zich bij executieveilingen hebben voorgedaan. Het artikel sluit af met twaalf conclusies ter voorkoming van incidenten, ongewenste handelwijzen en risico’s.
Medewerking door ondernemingen aan een strafrechtelijk onderzoek
Authors: Velthuis M. 
Published: June 2020

Medewerking door ondernemingen aan een strafrechtelijk onderzoek – Nopen nieuwe ontwikkelingen tot invoering van Nederlands beleid voor interne onderzoeken?
In Nederland is in 2019 hernieuwde aandacht ontstaan voor de interne onderzoekspraktijk, waaruit blijkt dat zowel de minister als het OM en de FIOD positief staan tegenover de interne onderzoekspraktijk. In het artikel pleit de auteur om Nederlands beleid te ontwikkelen met daarin incentives voor ondernemingen om deze vorm van medewerking te stimuleren. Tevens onderzoekt de auteur de noodzaak om de rechten van betrokkenen in het interne onderzoek vast te leggen. De auteur concludeert dat het aangewezen lijkt aan te sluiten bij de praktijk zoals ontwikkeld in de VS, waarbij in het geval van sturing door de autoriteiten aan het interne onderzoek onder dwang afgelegde verklaringen niet tegen de betrokkene mogen worden gebruikt in een strafrechtelijke procedure.
Het gebruik van een onderzoeksprotocol en de rol van de advocaat bij intern onderzoek nader bezien
Authors: Starmans J.C.G.T. , Liem V.S.Y. 
Published: June 2020

Het gebruik van een onderzoeksprotocol en de rol van de advocaat bij intern onderzoek nader bezien
In deze noot bij de uitspraak van het Hof van Discipline ’s-Hertogenbosch van 4 november 2019 wordt ingegaan op de normering die de tuchtrechter hanteert bij het oordelen over het handelen van een advocaat die feitenonderzoek verricht en werkzaam is voor een kantoor dat een onderzoeksprotocol heeft opgesteld.
Rare jongens die strafrechtelijke beginselen
Authors: Veenbrink J.M. 
Published: June 2020

Rare jongens die strafrechtelijke beginselen – De invloed van het strafrecht op het mededingingsrecht
In het mededingingsrecht is veel discussie over de waarborgen die van toepassing zijn. Zo beargumenteren ondernemingen vaak dat mededingingsautoriteiten hun fundamentele rechten hebben geschonden. Het is dan aan de rechters om te bepalen of dit inderdaad het geval is. In dit artikel wordt gekeken of er bij de ontwikkeling van deze waarborgen inspiratie wordt gehaald uit het strafrecht.
De Wet op het bevolkingsonderzoek op de schop: ‘het spoor helaas een beetje kwijtgeraakt’
Authors: Dondorp W.J. , Ploem M.C. 
Published: June 2020

De Wet op het bevolkingsonderzoek op de schop: ‘het spoor helaas een beetje kwijtgeraakt’
In deze bijdrage staan de plannen van de regering voor wijziging van de Wet op het bevolkingsonderzoek centraal. Doel van die wet – die eenmaal gewijzigd zal voortbestaan onder de titel Wet preventief gezondheidsonderzoek – is burgers te beschermen tegen bevolkingsonderzoeken die een risico opleveren voor hun lichamelijke gezondheid of psychisch welzijn. De auteurs brengen de belangrijkste voorgenomen wetswijzigingen in beeld, en plaatsen daar enkele kritische kanttekeningen bij.
Coronamaatregelen in de ggz: zorgen over rechtmatigheid en rechtsbescherming
Authors: Widdershoven T.P. 
Published: June 2020

Coronamaatregelen in de ggz: zorgen over rechtmatigheid en rechtsbescherming
Met het oog op de coronapandemie zijn in de intramurale ggz beduidende beperkingen doorgevoerd: het ontvangen van bezoek, de vrijheid van bewegen in de kliniek en het verlof om de kliniek te verlaten worden aanmerkelijk begrensd. In deze bijdrage worden vraagtekens geplaatst bij de rechtmatigheid van deze collectieve maatregelen die op instellingsniveau worden vastgesteld. Bedenkingen zijn er tevens ten aanzien van te signaleren beperkingen in het klachtrecht en inspectietoezicht. De rechtsbescherming van opgenomen psychiatrische patiënten lijkt medio april 2020 niet op orde.
Self-Assembly of GeMn Nanocolumns in GeMn Thin Films
Authors: Giang Le Thi 
Published: June 2020

This chapter presents the results of growing GeMn nanocolumns on Ge(001) substrates by means of molecular beam epitaxy (MBE). The samples have been prepared by co-depositing Ge and Mn at growth temperature of 130°C and Mn at concentration of ~6% to ensure the reproduction of GeMn nanocolumns. Based on the observation of changes in reflection high-energy electron diffraction (RHEED) patterns during nanocolumn growth, surface signals of GeMn nanocolumn formation have been identified. Structural analysis using transmission electron microscopy (TEM) show the self-assembled nanocolumns with core-shell structure extend through the whole thickness of the GeMn layer. Most of nanocolumns are oriented perpendicular to the interface along the growth direction. The nanocolumn size has been determined to be about 5–8 nm in diameter and a maximum height of 80 nm. A phenomenological model has been proposed to explain the driving force for self-assembly and growth mechanisms of GeMn nanocolumns. The in-plane or lateral Mn diffusion/segregation is driven by a low solubility of Mn in Ge while the driving force of Mn vertical segregation is induced by the surfactant effect along the [001] direction.
A mountain of millipedes IX: Species of the family Gomphodesmidae from the Udzungwa Mountains, Tanzania (Diplopoda, Polydesmida)
Authors: Olsen Sissel Anna , Rosenmejer Trine , Enghoff Henrik 
Published: June 2020

A new genus and six new species of the family Gomphodesmidae from the Udzungwa Mts are described, including Pogoro alopias Rosenmejer & Enghoff sp. nov., Pogoro siren Rosenmejer & Enghoff sp. nov., Pogoropsis prolixopes Rosenmejer & Enghoff gen. et sp. nov., Emphysemastix frampt Olsen & Enghoff sp. nov., Agrophogonus hamulus Olsen & Enghoff sp. nov., and Agrophogonus pusillokiellandi Olsen & Enghoff sp. nov. Emphysemastix dracarys Olsen & Enghoff sp. nov. from Iringa city is described. Descriptive notes are given for Pogoro scharffi Hoffman, 2005, and Agrophogonus mwanihana Hoffmann, 2005. General gomphodesmid gonopod morphology is described and illustrated. A key to Udzungwa gomphodesmids is presented, as well as revised keys to all species of Emphysemastix and Agrophogonus. All gomphodesmid species from the Udzungwa Mts are mapped.
Preoperative Osteopathic Manipulative Therapy Improves Postoperative Pain and Reduces Opioid Consumption After Total Knee Arthroplasty: A Prospective Comparative Study
Authors: Barral Pierre , Klouche Shahnaz , Barral Nathalie , Lemoulec Yves-Pierre , Thés André , Bauer Thomas 
Published: June 2020

Abstract

Context
Pain is a therapeutic challenge after total knee arthroplasty (TKA), and it could lead to the overuse of opioids. Few methodologically robust clinical studies have been performed to assess the effectiveness of osteopathic manipulative therapy (OMTh; manipulative care performed by non–US-trained osteopaths) for postsurgical pain.

Objective
To evaluate the effectiveness of standardized preoperative OMTh on early postoperative pain and opioid consumption after TKA.

Methods
This comparative, nonrandomized study took place from 2013 to 2015 and included patients who had primary unilateral TKA for osteoarthritis in a knee that had not undergone any previous surgery. Patients were divided into 2 consecutive groups: 1 group received traditional preoperative management, and the other group received associated preoperative OMTh (general OMTh [rhythmic mobilization of all the body joints, from the ankles to the skull, using long-lever manipulation] and myofascial relaxation). The primary evaluation criterion was knee pain at rest 1 month after surgery: 0 (no pain) to 100 (the worst imaginable pain). The secondary evaluation criteria were: (1) knee pain while walking 1 month after surgery, (2) average weekly knee pain during the first month after surgery, (3) the presence of night pain and the consumption of sleeping pills and opioids or morphine at least once per week, (4) the International Knee Society scores and the Western Ontario and McMaster University Osteoarthritis index at postoperative 6 months and 1 year. The number of patients needed for a superiority trial was determined.

Results
No eligible patient refused OMTh when proposed. Seventy patients were evaluated (mean [SD] age, 75 [8] years; 47 women and 23 men). The 2 treatment groups contained 35 patients each. At postoperative month 1, the OMTh group had significantly less pain at rest (mean [SD], 6.8 [6] vs 20.9 [17.3]; P=.00001) and while walking (7.9 [9.4] vs 23.5 [20.6]; P=.0001) compared with the group that received traditional preoperative management. The consumption of opioids during the first postoperative week was significantly lower in the OMTh group (P=.0001). No statistically significant difference was found in the International Knee Society or Western Ontario and McMaster University Osteoarthritis scores between the 2 groups at 6 months and 1 year of follow-up.

Conclusion
Standardized preoperative OMTh was found to be effective in reducing pain in the first month after TKA for osteoarthritis and significantly reduced opioid consumption during the first postoperative week.
Osteopathic Manipulative Treatment and Psychosocial Management of Dysmenorrhea
Authors: Matsushita Starr , Wong Bonnie , Kanumalla Raghu , Goldstein Leonard 
Published: June 2020

AbstractDysmenorrhea, or painful menstruation, is a common cause of acute pelvic pain that affects approximately two-thirds of women who are postmenarchal in the United States. Dysmenorrhea pain is frequently severe enough to disrupt daily activities and often accompanied by other symptoms, such as diarrhea, nausea, vomiting, headache, and dizziness. Primary dysmenorrhea is likely due to an excess of prostaglandins and is traditionally treated with nonsteroidal anti-inflammatory drugs and hormonal therapy. Secondary dysmenorrhea can have multiple origins and requires targeted therapy. Currently, musculoskeletal dysfunction and psychosocial factors are not listed as causes of secondary dysmenorrhea. The authors present a case in which the cause of secondary dysmenorrhea was thought to be related to both musculoskeletal dysfunction and emotional stress. Osteopathic manipulative treatment and lifestyle changes helped resolve secondary dysmenorrhea.