bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Navigated Task-specific fMRI on Direct Cortical Stimulation
Authors: Leote Joao , Loução Ricardo , Viegas Catarina , Lauterbach Martin , Perez-Hick António , Monteiro Joana , Nunes Rita G. , Ferreira Hugo A. 
Published: July 2020

Abstract
Background and Study Aims Cortical mapping (CM) with direct cortical stimulation (DCS) in awake craniotomy is used to preserve cognitive functions such as language. Nevertheless, patient collaboration during this procedure is influenced by previous neurological symptoms and growing discomfort with DCS duration. Our study aimed to evaluate the impact of navigated task-specific functional magnetic resonance imaging (nfMRI) on the practical aspects of DCS.
Material and Methods We recruited glioma patients scheduled for awake craniotomy for prior fMRI-based CM, acquired during motor and language tasks (i.e., verb generation, semantic and syntactic decision tasks). Language data was combined to generate a probabilistic map indicating brain regions activated with more than one paradigm. Presurgical neurophysiological language tests (i.e., verb generation, picture naming, and semantic tasks) were also performed. We considered for subsequent study only the patients with a minimum rate of correct responses of 50% in all tests. These patients were then randomized to perform intraoperative language CM either using the multimodal approach (mCM), using nfMRI and DCS combined, or electrical CM (eCM), with DCS alone. DCS was done while the patient performed picture naming and nonverbal semantic decision tasks. Methodological features such as DCS duration, number of stimuli, total delivered stimulus duration per task, and frequency of seizures were analyzed and compared between groups. The correspondence between positive responses obtained with DCS and nfMRI was also evaluated.
Results Twenty-one surgeries were included, thirteen of which using mCM (i.e., test group). Patients with lower presurgical neuropsychological performance (correct response rate between 50 and 80% in language tests) showed a decreased DCS duration in comparison with the control group. None of the compared methodological features showed differences between groups. Correspondence between DCS and nfMRI was 100/84% in the identification of the precentral gyrus for motor function/opercular frontal inferior gyrus for language function, respectively.
Conclusion Navigated fMRI data did not influence DCS in practice. Presurgical language disturbances limited the applicability of DCS mapping in awake surgery.
Evaluation of Low-Dose Ketamine on Inflammatory Biomarker Profile Following Off-Pump Coronary Artery Bypass Grafting
Authors: Singh Daljeet , Kashav Ramesh , Magoon Rohan , Kohli Jasvinder Kaur , Kaur Mohandeep , Gupta Aastha , Gupta Vijay 
Published: July 2020

AbstractThe role of ketamine in attenuating the postoperative inflammatory response is a subject of recent clinical interest. Despite several studies elucidating the anti-inflammatory potential of ketamine in on-pump coronary artery bypass grafting and noncardiac surgeries, the literature on the role of ketamine in ameliorating systemic inflammatory response syndrome following off-pump coronary artery bypass grafting (OPCAB) is rather scarce. This prospective observational study was designed to compare the postoperative inflammatory milieu with and without the addition of low dose (0.5 mg/kg) of ketamine to the anesthetic regimen in the patients undergoing OPCAB, wherein 60 patients were allocated to group T, receiving ketamine (n = 30) and the group C, not receiving ketamine (n = 30). The estimated biomarkers included C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), troponin T, and creatine kinase-MB (CK-MB) at the following time points: prior to induction (T0), immediate postoperative period (T1), 4 hours postoperatively (T2), 24 hours postoperatively (T3), and 48 hours postoperatively (T4). The major finding of the study was a significant reduction in the postoperative values of CRP and IL-6 at T1, T2, T3, and T4 (p < 0.001) However, postoperative serum levels of TNF-α, CK-MB, and troponin T were comparable in the group T and group C. The average postoperative CRP and IL-6 levels positively correlated with the VISh (the highest postoperative vasopressor inotrope score) with the r values of 0.733 (p < 0.001) and 0.704 (p < 0.001), respectively. The index study substantiates the anti-inflammatory potential of ketamine in preventing immune function alterations attributable to anesthesia and cardiac surgery.
Prevalence of Dental Fear and Anxiety among Russian Children of Different Ages: The Cross-Sectional Study
Authors: Sarapultseva Maria , Yarushina Maria , Kritsky Igor , Ibragimov Roman , Sarapultsev Alexey 
Published: July 2020

Abstract
Objective Children’s dental fear may lead to an avoidance of seeking dental care or disruptive behavior during treatment. The study was aimed to evaluate the prevalence and scores of dental fear and anxiety (DFA) among Russian children of different ages with an experience of dental treatment.
Materials and Methods The cross-sectional study included 371 children aged 2 to 17 years. Study participants were divided into three groups according to their age: 112 “preschool children” aged 2 to 5 years, 137 “school children” aged 6 to 11 years, and 122 “adolescents” aged 12 to 18 years. The questionnaires were distributed at reception areas of the dental clinic to parents of children aged 2 to 5 years and to the older children themselves.
Statistical Analysis Data analysis was performed using SPSS version 15.0. The parametric tests were used (one-way ANOVA, Student’s t-test, and Pearson’s correlation) because of the expected sample of more than 100 observations. The chi-square test was used for categorical variables.
Results The data have shown that 93.8% of the Russian child population visiting dental offices suffer mostly from moderate (11.85) levels of DFA. DFA was more often revealed in girls and among the youngest children aged 2 to 5 years.
Conclusions According to the obtained results, children were more afraid of “tooth drilling” and an “injection of local anesthetic” than other factors mentioned in the questionnaires. Fear of dental treatment is common among Russian children, and the factors associated with it differ with the gender and age of the child.
Skepi Dutch Creole
Authors: Jacobs Bart , Parkvall Mikael 
Published: July 2020

Abstract
In this article we present newly found lexical and grammatical data pertaining to Skepi, the Dutch-lexified creole which
is now extinct but was once widespread in the Essequibo area of what is today the Republic of Guyana. The source of this new material are
the linguistic notes contained in the diary of Reverend Thomas B. Youd, a missionary in service of the Church Missionary Society, who was
active in the area from 1833 to 1842.
“But what about the beginning?”
Authors: Kelly Kimberly R. , Ocular Grace , Zamudio Jennifer , Plascencia Jesus 
Published: July 2020

Abstract
This mixed model study first implemented a quantitative approach to investigate the structural coherence of the narratives
that 3- to 6-year old children construct with and without their mothers. We then employed qualitative analysis to identify and categorize
strategies that mothers used to scaffold their children’s developing sequencing skill during narrative conversations. Analysis of 233
co-constructed and 209 independent past-event narratives from 65 mother-child dyads revealed that the children produced narratives with a
range of structural coherence both independently and with maternal assistance. Chronological narratives were the most common structure
produced with and without assistance, but leapfrog narratives persisted in the dyadic context. Five distinct patterns of maternal strategies
that provided chronological structure to their children’s leapfrogs emerged. We discuss the ways in which the maternal strategies identified
promote early literacy skills through scaffolding and modeling school-like literacy practices in everyday conversations.
Pragmática y simbolización
Authors: Frühbeck Moreno Carlos 
Published: July 2020

Abstract
Firstly, this paper aims to provide new theoretical insights in the study of literary symbolism with the support of
Relevance Theory, Lexical Pragmatics and some contributions of second-generation cognitive sciences. Specifically, it proposes that the
meaning of literary symbol consists on the tension between a “literal” meaning and a not paraphrasable abstract meaning. Furthermore,
literary symbol needs of a specific communicative context: the “symbolic reading”, whose features are defined.
In order to analyze the meaning of literary symbol a perspective close to contextualism has been taken. So, we consider
that meanings are underdeterminated and context is always needed to obtain them. The tension between the literal and the abstract meaning is
explained with the aid of Rayo´s grab bag model of language mastery and Relevance Theory accounts of metaphor comprehension.
Lastly, this framework is applied to the analysis of Juan Eduardo Cirlot’s works, with special attention to his
permutation poetry.
Preliminary Studies on Design of Photovoltaic Thermal (PVT) Solar Collector for Roofing System Application.
Authors: Abdul Manap Zariq Imran , Wahab Hanani Abd , Pauline Ong , Ismail Al-Emran , Ismon Maznan , Mohamad Zaleha 
Published: July 2020

Abstract
This study was conducted to develop and study the performance of a Photovoltaic Thermal (PVT) system technology, a system which combines the Photovoltaic (PV) system with a solar thermal (T) system that produces electricity and hot water simultaneously. The objective of this study is to develop a working prototype of the PVT system for roofing system application with water as the cooling agent. A polycrystalline PV cells was used as the solar collector while a transparent rubber tube was attached at the backside of the PV panel with water flowing directly from a water tap source. Two designs were examined for the heat absorber design which was categorized as the parallel and spiral flow design. The system was run at an open space to simulate real life application. A working PVT system was developed; however an electrical efficiency drops 0.3% and 1.07% on the parallel and spiral design respectively when compared to the standard PV system.
Multi objective optimization of Indoor UHF RFID Network Based on Gradient - Cuckoo search
Authors: Talib Nihad Hasan , Hasnan Khalid Bin , BinNawawi Azli , Elewe Adel , Abdullah Haslina Binti 
Published: July 2020

Abstract
Network design, in general is a critical concept due to its effect on efficiency, cost and other significant factors. In recent years, RFID is widely applied for RNP Network design. The large -area network design process requires a significant number of interrogating antennas based on the reader-tag range communication. RFID technology uses a huge number of tags communicate with a small number of the reader, from thus point of view, the challenges of large scale RNP problems include high computational cost due to the time consumption of RFID readers placement error, as a result, these challenges reduce the effectiveness of the RFID system In this study, a model of multi-objective function for RFID reader placement was conducted on various large -area condition to evaluate the impact of network design expansion. A comparative analysis was performed with (GBCS algorithm) Gradient-Based Cuckoo Search. The dataset was performed for the area of 80m x 80m and 150m x 150m. Simulation results exhibited that the performance of (GBCS) Gradient-Based Cuckoo presented a minimum number of deployed readers with maximum RFID tags coverage and was superior in solving large scale RFID-NP problems. Simulation results not only explained that the present algorithm is strong and workable but also showed excellent approximation abilities even in the high scale-area. Consequently, the authors recommend if the area bigger than (80m2), there is a need to divide the area into separate regions and deal with each region separately to be sure that the objective function can work efficiently.
Damage Initiation and Evolution Analysis of Hot Extruded Recycled Aluminium Alloys (AA6061)
Authors: Ho C. S. , Mohd Nor M. K. , Ma’at N. , Alaric Sim K. Y. , Ibrahim M. N. , Jamian S. , Lajis M. A. , Yusuf N. K. 
Published: July 2020

Abstract
The effects of strain rate on the mechanical behaviour of recycled hot extruded aluminium alloys (AA6061) are investigated using uniaxial tensile tests in this work. The damage characteristics such as micro-cracks and micro-voids are analysed on the microstructure of the material using Scanning Microscope Electron (SEM). It is shown that the mechanical behaviour of the recycled AA6061 is influenced by the loading speed. Besides, the damage parameters such as the micro-cracks and micro-voids in the material are evolved significantly in such materials during finite strain deformation. It can be observed that the evolution speed of the micro-cracks and micro-voids in the materials is increasing with the increase in loading speed. Much work is still required to improve the recycled AA6061 as compared to the primary resources in terms of damage parameters initiation and evolution.
Descriptive statistics analysis of the variable in the data of toothbrushing simulator system modelling
Authors: Salleh Salihatun Md , Mansor Mohamad Norani , Hassan Hadirah , Mohd Yusoff Ainul Husna , Md Zin Badrul Aisham , Yahya Musli Nizam , Wijianto S. T. 
Published: July 2020

Abstract
The controller of a system can be designed by constructing the model from the known the input and output. Modelling the dynamic of the system can help to visualize the real behavior of the system to develop the suitable controller parameter. The measured data from the real system need to be analyzed statistically to support that the current system needs a controller to improve the system performance. This study analyzed the normality and linearity of the variables in the research data of Toothbrushing Simulator System Modelling which are Speed (RPM) as the output(Y) and Voltage (V) as the input (X). There were five different data sets with 1000 observations respectively. All the data had been analyzed by using IBM SPSS Statistics 23 in which it will be explained by graphical method of histogram, scatter plot and descriptive measures of coefficient f determination between variables. The results for this study turn out that all the data sets were not normally distributed and not linear. Hence, the result from this statistical analysis has proven that the controller development is very crucial for the toothbrushing simulator system to improvise the system performance.
Isolation, Identification, and Inhibition of Saponin Isolates from Pineapple (Ananas comosus L.) and Candlenut (Aleurites moluccanus L.) against Xanthine Oxidase by In Vitro Assay
Authors: Amalia Mimma , Alvionita Mieke , Subandi  , Susanti Evi , Nugraheni Dian 
Published: July 2020

Abstract
The exploration of gout treatment agent based on the natural product gains high attention in recent years. Although some current drugs effectively treat gout, fewer unbeneficial effects cannot be avoided. Thus, searching for new alternatives with fewer side effects is needed. This present work was aimed at investigating the potency of saponins in pineapple (Ananas comosus L.) and candlenut (Aleurites moluccanus L.) extract as an inhibitor of xanthine oxidase, an enzyme that responsible for gout disease, by in vitro study. The stage of this work was divided into six stages, including (1) sample preparation, (2) extraction of saponins using 70% ethanol, (3) isolation of saponins by thin-layer chromatography, (4) phytochemical test of saponins, (5) inhibitory activity testing of saponins using in vitro analysis, and (6) determination the types of saponins by UV-Vis, FT-IR and LC-MS/MS spectroscopy. The result from the preparative TLC of pineapple extract, there were three spots with Rf value of 0.95 (pi1), 0.65 (pi2), and 0.38 (pi3), while from candlenut extract there were two saponin isolates with Rf value of 0.95 (ci1) and 0.79 (ci2). The inhibition activity of each isolate against xanthine oxidase was 103.41% (pi1), 269.73% (pi2), 84.16% (pi3), 222.90% (ci1), and 157.05% (ci2) relative to Allopurinol 100 ppm. Based on spectroscopic analysis results, isolate with the greatest inhibition activity was likely a diosgenin type (C27H42O3) of saponin.
Preliminary Phytochemical Screening and Fluorescence Characterization of Several Medicinal Plants Extract from East Java Indonesia
Authors: Fardiyah Q , Suprapto  , Kurniawan F , Ersam T , Slamet A , Suyanta  
Published: July 2020

Abstract
The preliminary phytochemical screening and fluorescence characterization of several medicinal plant extracts from East Java Indonesia have been carried out. Some medicinal plants used in this study are Annona muricata, Strobilanthes crispus, Piper ornatum and Andrographis paniculata. The objective of this research is to find out the result of phytochemical screening and characterization of several medicine plants by fluorescence spectroscopy. The plant part in the form of leaves is extracted using maceration method. The extraction process was carried out for 3 days with ethanol solvent in room temperature. The result of preliminary phytochemical screening showed the existence of secondary metabolite compounds in several medicinal plant extracts, among others, alkaloid, saponin, terpenoid, steroid, tannin and flavonoid. The fluorescence characterization spectra obtained shows that several medicinal plant extracts have optimum absorption at wavelength of excitation of 323 – 342 nm and wavelength of emission of 662 – 685 nm.
The Reduction of Cadmium Concentration by Oscillatoria Microalgae in a Culture Media
Authors: Hentiana  , Setiawan Doni , Mohadi Risfidian , Hermansyah  , Zulkifli Hilda 
Published: July 2020

Abstract
Microalgae has functional group such as carboxylic (-COOH) and hydroxyl (-OH) which play an important role as adsorbent of heavy metal. Reduction of cadmium concentration by Oscillatoria microalgae in a culture medium has been carried out. This research aimed to study the ability of Oscillatoria microalgae as a biological adsorbent agent of cadmium heavy metal using BG-11 media. There were four treatments culture media with six repetitions consisting of P0 = 100 mL medium + 10,000 individual Oscillatoria; P1 = 1 mg/L Cd(II) + 100 mL medium + 10,000 individual Oscillatoria; P2 = 3 mg/L Cd(II) + 100 mL medium + 10,000 individual Oscillatoria; and P3 = 5 mg/L Cd(II) + 100 mL medium + 10,000 individual Oscillatoria. The result has shown the increasing of Oscillatoria in BG-11 culture media starting from day 4 to day 7 day was around 1208-1599 ind/L/day. P3 treatment which consist of 1 mg/L show the highest reduction of cadmium absorption with percentage of 24.05%, compared to the others.
Thiocyanate Doping in Gel-Growth Cobalt Oxalate Crystals
Authors: Khunur Mohammad Misbah , Wahyuni Dini Tri , Kurniawan Gigih Wahyu , Prananto Yuniar Ponco 
Published: July 2020

Abstract
The presence of other anions, as impurities and/or doping agents, may alter crystallization and the properties of the crystal. The objective of this research is to examine the effect of thiocyanate doping in the synthesis of cobalt oxalate crystals grown in silica gel. The synthesis was conducted at room temperature for 12 weeks in a U-tube glass filled with silica gel. The gel was prepared from Na2SiO3 at pH 5 using dilute HNO3 with a gelling time of 5 days. Supernatant solutions of (NH4)2C2O4 and Co(NO3)2/KSCN were added on each side of the tube. The Co(NO3)2 and KSCN were firstly mixed before adding onto the gel to increase the possibility of thiocyanate doping in the crystals. Various molar ratio of Co(II):C2O4
−2:SCN− were used (1:1:0, 1:1:1, 1:1:2, 1:1:3, 1:1:4, and 1:1:5). FT-IR and SEM were used to analyse the crystal. The result shows that red block crystals were formed. FTIR analysis for all molar ratios reveals that they all give considerably identical spectra with an absence of thiocyanate peaks around 2200 cm−1, suggesting that all molar ratios give an identical product of cobalt(II) oxalate hydrate. SEM analysis shows that the size of the crystals was significantly bigger than previously reported crystals. The Co(II) centre binds to the oxalate ligand, and not to the thiocyanate, due to chelating effect. However, inconclusive findings were observed regarding the influence of the molar ratio on the crystals yield. The use of a higher concentration of thiocyanate (fivefold molar ratio) did not affect the composition of the product, and the product remains crystallized as cobalt(II) oxalate hydrate.
Isolation and Optical Properties of Natural Pigments from Purple Mangosteen Peels
Authors: Kurniawan Yehezkiel Steven , Fahmi M. Riza Ghulam , Yuliati Leny 
Published: July 2020

Abstract
Purple mangosteen (Garcinia mangostana) has several biological applications such as anticancer, antitubercular and antioxidant agents. In this work, we isolated and studied the optical properties of the natural pigments from the purple mangosteen peels. To isolate the natural pigments, the mangosteen peels were macerated using distilled water, ethanol, or acetone for 24 h. The extracts were filtrated and characterized using spectrophotometers of Fourier transform infrared (FTIR), ultraviolet-visible (UV-Vis), and spectrofluorometer. The extracts gave the FTIR vibration peaks of O-H, C-H sp3, C=O, C=C, and C-O functional groups, while absorption peaks at 210–374 nm were observed in the UV-Vis spectra of the extracts due to the presence of mangostins, anthocyanins, and phenolic acids. The three-dimensional fluorescence spectra showed that the excitation and emission peaks of the mangosteen peels extracted with ethanol were found at 444 and 498 nm, respectively, while that extracted with distilled water gave no significant fluorescence peaks. On the other hand, the mangosteen peels extracted with acetone gave the strongest emission intensity at 472 and 502 nm due to the most intense color intensity. This study provided useful information about the optical properties of natural pigments extracted from purple mangosteen peels through a simple isolation technique.
Effects of Growth Medium on Extracellular Secretion of Human Epidermal Growth Factor in Escherichia coli by Co-expression with Bacillus cereus Phospholipase C
Authors: Latifah F P U , Indriyani A , Pratiwi R D , Sriwidodo  , Maksum IP 
Published: July 2020

Abstract
Human Epidermal Growth Factor (hEGF) is a small, mitotic growth polypeptide that promotes the proliferation of various cells and is widely applied in clinical practices, especially in therapeutic uses of wound healing. Since it has a lot of benefits, production of recombinant hEGF (rhEGF) in a large scale is needed. Some methods have been used in this protein production, one of them was the production of rhEGF using extracellular secretion in Escherichia coli. Previous research have been done using co-expression method with phospholipase C from Bacillus cereus to increase the amount of rhEGF. Phospholipase C B. cereus have been used in several protein expression and was proved that it could increase the secretion of recombinant protein through hydrolytic mechanism of cell membrane. In addition, growth condition is one of some major factors which can affect the yields of produced protein. Different compositions of bacterial growth medium often lead to different result. This paper studies how rich-nutrient Terrifict Broth (TB) medium and Luria Bertani (LB) medium produced different rhEGF results when it was co-expressed with phospholipase C B. cereus. rhEGF was characterized using SDS-PAGE and confirmed by western blot using anti-mouse EGF, and its concentration was measured using ELISA. rhEGF was successfully characterized after co-expression in TB medium and the concentration was 503.48 μg/mL. rhEGF was better produced in TB medium rather than in LB medium since TB medium has richer composition.