bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Spatial and Functional Interaction of a Heterotetramer Survivin–DNA-PKcs Complex in DNA Damage Response
Authors: Güllülü Ömer , Hehlgans Stephanie , Mayer Benjamin E. , Gößner Ines , Petraki Chrysi , Hoffmann Melanie , Dombrowsky Maximilian J. , Kunzmann Patrick , Hamacher Kay , Strebhardt Klaus , Fokas Emmanouil , Rödel Claus , Münch Christian , Rödel Franz 
Published: January 2021

AbstractSubstantial evidence has shown that overexpression of the inhibitor of apoptosis protein (IAP) survivin in human tumors correlates significantly with treatment resistance and poor patient prognosis. Survivin serves as a radiation resistance factor that impacts the DNA damage response by interacting with DNA-dependent protein kinase (DNA-PKcs). However, the complexity, molecular determinants, and functional consequences of this interrelationship remain largely unknown. By applying coimmunoprecipitation and flow cytometry-based Förster resonance energy transfer assays, we demonstrated a direct involvement of the survivin baculovirus IAP repeat domain in the regulation of radiation survival and DNA repair. This survivin-mediated activity required an interaction of residues S20 and W67 with the phosphoinositide 3-kinase (PI3K) domain of DNA-PKcs. In silico molecular docking and dynamics simulation analyses, in vitro kinase assays, and large-scale mass spectrometry suggested a heterotetrameric survivin–DNA-PKcs complex that results in a conformational change within the DNA-PKcs PI3K domain. Overexpression of survivin resulted in enhanced PI3K enzymatic activity and detection of differentially abundant phosphopeptides and proteins implicated in the DNA damage response. The survivin–DNA-PKcs interaction altered the S/T-hydrophobic motif substrate specificity of DNA-PKcs with a predominant usage of S/T-P phosphorylation sites and an increase of DNA-PKcs substrates including Foxo3. These data demonstrate that survivin differentially regulates DNA-PKcs-dependent radiation survival and DNA double-strand break repair via formation of a survivin–DNA-PKcs heterotetrameric complex.Significance:These findings provide insight into survivin-mediated regulation of DNA-PKcs kinase and broaden our knowledge of the impact of survivin in modulating the cellular radiation response.See related commentary by Iliakis, p. 2270
Smart hand gestures recognition using K-NN based algorithm for video annotation purposes
Authors: Alksasbeh Malek Zakarya , AL-Omari Ahmad H , Alqaralleh Bassam A. Y. , Abukhalil Tamer , Abukarki Anas , Alshalabi Ibrahim Alkore , Alkaseasbeh Amal 
Published: January 2021

<span>Sign languages are the most basic and natural form of languages which were used even before the evolution of spoken languages. These sign languages were developed using various sign "gestures" that are made using hand palm. Such gestures are called "hand gestures". Hand gestures are being widely used as an international assistive communication method for deaf people and many life aspects such as sports, traffic control and religious acts. However, the meanings of hand gestures vary among different civilization cultures. Therefore, because of the importance of understanding the meanings of hand gestures, this study presents a procedure whichcan translate such gestures into an annotated explanation. The proposed system implements image and video processing which are recently conceived as one of the most important technologies. The system initially, analyzes a classroom video as an input, and then extracts the vocabulary of twenty gestures. Various methods have been applied sequentially, namely: motion detection, RGB to HSV conversion, and noise removing using labeling algorithms. The extraction of hand parameters is determined by a K-NN algorithm to eventually determine the hand gesture and, hence showing their meanings. To estimate the performance of the proposed method, an experiment using a hand gesture database is performed. The results showed that the suggested method has an average recognition rate of 97%. </span>
Conventional doped silica/fluoride glass fibers for low loss and minimum dispersion effects
Authors: M. Alatwi Aadel , Zaki Rashed Ahmed Nabih 
Published: January 2021

<p><span>This paper has clarified the conventional silica doped (SiGeO2) and aluminum fluoride (AlF3) fibers for low loss and minimum dispersion effects for upgrading fiber-optic communication systems. The total dispersion with the total losses are modeled for both fibers. Fiber bandwidth and the power received are estimated based on different dopant ratios. The spectral and thermal effects are applied on both fibers. The study assured the negative effects of increasing ambient temperatures and the positive effects of increasing dopant ratios on the performance of the fibers. </span></p>
Significant features for steganography techniques using deoxyribonucleic acid: a review
Authors: Asaad Zebari Nichirvan , Asaad Zebari Dilovan , Qader Zeebaree Diyar , Najeeb Saeed Jwan 
Published: January 2021

<p><span>Information security and confidentiality are the prime concern of any type of communication. Rapidly evolution of technology recently, leads to increase the intruder’s ability and a main challenge to information security. Therefore, utilizing the non-traditional basics for information security is required, such as DNA which is focused as a new aspect to achieve better security. In this paper, a survey of more recent DNA based on data hiding algorithms are covered. With particular emphasis of different parameters several data hiding algorithms based on DNA has been reviewed. To present a more secure an efficient data hiding algorithms based on DNA for future works, this willbe helpful. </span></p>
Fractional order PID controller tuned by bat algorithm for robot trajectory control
Authors: A. Faraj Mohammad , Mohammed Abbood Abdulsalam 
Published: January 2021

<span>This paper deals with implementing the tuning process of the gains of fractional order proportional-integral-derivative (FOPID) controller designed for trajectory tracking control for two-link robotic manipulators by using a Bat algorithm. Two objective functions with weight values assigned has been utilized for achieving the minimization operation of errors in joint positions and torque outputs values of robotic manipulators. To show the effectiveness of using a Bat algorithm in tuning FOPID parameters, a comparison has been made with particle swarm optimization algorithm (PSO). The validity of the proposed controllers has been examined in case of presence of disturbance and friction. The results of simulations have clearly explained the efficiency of FOPID controller tuned by Bat algorithm as compared with FOPID controller tuned by PSO algorithm. </span>
Investigation on the PAPR performance of odd-bit QAM constellations for DFT spread OFDM systems
Authors: M. Sana Ahmed , T. Saeed Amer , Kh. Yaseen Yaseen 
Published: January 2021

<p>Adaptive quadrature amplitude modulation (QAM) is a crucial scheme that enables the modern communication systems to overcome the adverse effects of channel fluctuations and maintain an acceptable spectral efficiency. In order to enhance adaptive modulation even further, adoption of odd-bit QAM constellations alongside even constellations had been suggested to improve the transmission efficiency of adaptive QAM modulation. Hence, odd-bit QAM had been extensively studied, analyzed, and tested by many researchers for various patterns, sizes, and communication systems in terms of bit error rate (BER) and peak to average power ratio (PAPR). However, the PAPR performance of odd-bit QAM constellation with single carrier transmission systems adopted in the uplink of the 4G long term evolution (LTE) standards caught almost no research interest. In this paper, the PAPR performance of both cross and rectangular odd-bit QAM constellations are investigated for DFT-S-OFDM systems. Complementary cumulative distribution functions (CCDFs) and probability density functions (PDFs) curves for PAPR are also obtained. Finally, an equation for PAPR PDF is empirically derived for odd-bit cross QAM based DFT-S-OFDM. The results show that cross odd-bit QAM outperforms the rectangular odd-bit QAM in terms of PAPR by 1.02 dB for 8-QAM and 1.3 dB for 32-QAM. This proves that cross odd-bit QAM is a better choice in terms of PAPR for DFT-S-OFDM systems. </p>
Classification techniques’ performance evaluation for facial expression recognition
Authors: Mahmood Mayyadah R. , Abdulrazaq Maiwan B. , Zeebaree Subhi R. M. , Ibrahim Abbas Kh. , Zebari Rizgar Ramadhan , Dino Hivi Ismat 
Published: January 2021

<p><span>Facial exprestion recognition as a recently developed method in computer vision is founded upon the idea of analazing the facial changes in which are witnessed due to emotional impacts on an individual. This paper provides a performance evaluation of a set of supervised classifiers used for facial expression recognition based on minimum features selected by chi-square. These features are the most iconic and influential ones that have tangible value for result dermination. The highest ranked six features are applied on six classifiers including multi-layer preceptron, support vector machine, decision tree, random forest, radial baised function, and k-nearest neioughbor to figure out the most accurate one when the minum number of features are utilized. This is done via analyzing and appraising the classifiers’ performance. CK+ is used as the research’s dataset. Random forest with the total accuracy ratio of 94.23 % is illustrated as the most accurate classifier amongst the rest. </span></p>
A secure cloud service deployment framework for DevOps
Authors: Ravinder Rao , Sucharita V. 
Published: January 2021

<span>The advancements in cloud computing and leveraging the benefits from cloud computing to the service providers have increased the deployment of traditional applications to the cloud. The applications once deployed on the cloud, due to various reasons, need migration from development infrastructure to operational infrastructure, one operational instance to other operational instances due to load balancing and the cycle continues due to the use of DevOps as development strategies for cloud computing applications. Advocates of hybrid and public clouds observe cloud computing makes it possible for organizations to avert or minimize upfront IT infrastructure expenses. Proponents also assert that cloud computing systems permit businesses to receive their software up and running faster, using improved manageability and less maintenance, so it empowers IT teams to rapidly adapt tools to meet the varying and unpredictable requirements. DevOps is a lot of practices that mechanizes the procedures between programming improvement and IT groups, all together that they can fabricate, test, and discharge programming quicker and even more dependably. The idea of DevOps is established on building a culture of a joint effort between groups that generally worked in relative siloes. The guaranteed advantages incorporate expanded trust, quicker programming discharges, capacity to explain basic issues rapidly and better oversee impromptu work. Thus, this work identifies the need for providing multiple security protocols during the complete life cycle of cloud application development and deployment. This work proposes a novel framework for automatic selection and deployment of the security protocols during cloud service deployments. The framework identifies the need for security aspects and selects the appropriate security algorithms for virtual machines. The proposed framework demonstrates nearly 80% improvement over the security policy deployment time. </span>
High speed pulse generators with electro-optic modulators based on different bit sequence for the digital fiber optic communication links
Authors: M. A. Eid Mahmoud , S. Seliem Ashraf , Zaki Rashed Ahmed Nabih , A. Mohammed Abd El-Naser , Ali Mohamed Yassin , S. Abaza Shaimaa 
Published: January 2021

<p><span>The paper outlines the simulation of various pulse generators for the enhancement of optical fiber access transmission networks within flow rate of 10 Gbps and transmission range of 100 km. The pulse generators are gaussian, hyperbolic secant, triangle, sine, raised cosine in the transmission stage. Proposed pulse generators are mixed with both electro-absorption modulator (EAM) and mach-zehnder modulator (MZM) for efficient transmission. We have compared the max. the quality factor with using proposed pulse generators against nonreturn to zero (NRZ) return to zero (RZ) pulse generators in the previous research works for different bit sequences. The signal power amplitude is tested for both optical fiber and PIN photodetector optical time-domain visualizer and RF spectrum analyzer by using in the optimum cases for different bit sequence. It is observed that proposed pulse generators/EAM have presented an efficient increase in Q-factor value compared with proposed pulse generators/MZM for different bit sequences.</span></p>
The PBY Catalina’s Offensive Utility and Its Transformation into Black Cats and MAD Cats
Authors: Cecil Patrick 
Published: January 2021

Abstract
By the Second World War the US Navy had slated the pby Catalina to function as its long-range patrol seaplane and considered it for a bombing role. The first months of the war, however, revealed the pby to be too antiquated and slow to be a viable offensive weapon and thus minimized its utility. Relegated to conducting patrols and rescue operations, pby crews looked to the aircraft itself and experimented with technical and operational changes in reaction to fighting the Japanese in the South Pacific and the U-boat threat in the Atlantic. With the blessing of Navy’s command structure, crews made physical adjustments, added the latest technologies, incorporated supporting armaments, and designed new operational methods on an ad hoc basis for their respective circumstances and opponent. This experimentation and innovation resulted in the enhancement of the pby’s offensive utility as an attack weapon, and its transformation into the Black Cats and mad Cats.
Ambient Temperature Is an Independent Risk Factor for Acute Tonsillitis Incidence
Authors: Chen Jian , Zhang Yibo , Zhang Xin , Jiang Yingfang , Huang Yibo 
Published: January 2021

Objective: Acute tonsillitis is a common disease in otorhinolaryngology. Meteorological factors can affect the incidence of many infectious diseases. This study aims to analyze the correlation between acute tonsillitis and meteorological conditions. Materials and Methods: We collected the meteorological data, including daily temperature, humidity, and fine particulate matter (PM2.5) of Shanghai, China, from 2014 to 2015. The monthly number of acute tonsillitis cases in our hospital was also calculated and used as the outcome variable. The associations between them were evaluated, respectively. Results: The average number of patients diagnosed with acute tonsillitis in our hospital per month was 68.67 ± 18.67 from 2014 to 2015. The average temperature, humidity, and PM2.5 of Shanghai during the defined period was 16.84 °C ± 7.80 °C, 75.93% ± 5.45%, and 52.38 ± 14.23 μg/m3, respectively. The temperature was significantly positively associated with the acute tonsillitis cases number both in Pearson correlation analysis ( R = 0.423, P = .039) and in multivariate regression analysis (coefficient =2.194, P = .012). However, no correlation between the acute tonsillitis cases number and relative humidity or PM2.5 was found through a multivariate regression model ( P = .225 and P = .243), respectively. Conclusion: The high temperature was associated with an increased incidence of acute tonsillitis.
Mineralogy of volcanic calciocarbonatites from the Trig Point Hill debris flow, Kerimasi volcano, Tanzania: implications for the altered natrocarbonatite hypothesis
Authors: Mitchell Roger H. , Dawson J. Barry 
Published: January 2021

AbstractA major debris flow, the Trig Point Hill flow, originating from Kerimasi volcano (Tanzania) contains numerous blocks of extrusive/pyroclastic carbonatites similar to those exposed at the rim of the currently inactive crater. The blocks of calcite carbonatite consist of: (1) large clasts of corroded and altered coarse grained calcite; (2) primary prismatic inclusion bearing phenocrystal calcite; and (3) a matrix consisting primarily of fine-grained prismatic calcite. The large clasts are inclusion free and exhibit a ‘corduroy-like’ texture resulting from solution along cleavage planes. The resulting voids are filled by brown Fe–Mn hydroxides/oxides and secondary calcite. The prismatic or lath-shaped phenocrystal calcite is not altered and contains melt inclusions consisting principally of primary Na–Ca carbonates which contain earlier-formed crystals of monticellite, periclase, apatite, Mn–Mg-magnetite, Mn–Fe-sphalerite and Nb-perovskite. Individual Na–Ca carbonate inclusions are of uniform composition, and the overall range of all inclusions analysed (wt.%) is from 28.7 to 35.9 CaO; 16.7–23.6 Na2O; 0.5–2.8 K2O, with minor SO3(1.1–2.2) and SrO (0.34–1.0). The Na–Ca carbonate compositions are similar to that of shortite, although this phase is not present. The Na–Ca carbonates are considered to be primary deuteric phases and not secondary minerals formed after nyerereite. Monticellite shows limited compositional variation and contains 2–4 wt.% MnO and 12 wt.% FeO and is Mn-poor relative to monticellite in Oldoinyo Lengai natrocarbonatite. Periclase is Fe-bearing with up to 13 wt.% FeO. Spinels are Cr-free, Mn-poor and belong to the magnetite–magnesioferrite series in contrast to Mn-rich spinels of the magnetite–jacobsite series occurring in Oldoinyo Lengai natrocarbonatite. The matrix in which the ‘corduroy’ clasts and phenocrystal calcite are set consists of closely packed small prisms of calcite lacking melt inclusions, with interstitial fine-grained apatite, baryte, strontianite and minor fluorite. Pore spaces are filled with secondary Mn–Fe hydroxides/oxides, anhydrite and gypsum. The hypothesis that flow-aligned calcite in volcanic calciocarbonatites from Kerimasi, Tinderet, Homa and Catanda is altered nyerereite is discussed and it is considered that these calcite are either primary phases or altered melilite. The nyerereite alteration hypothesis is discussed with respect to the volumetric and compositional aspects of pseudomorphism by dissolution–precipitation replacement mechanisms. This study concludes that none of the volcanic calciocarbonatites containing flow-aligned calcite phenocrysts are altered natrocarbonatite.
The clinical value of cardiopulmonary exercise testing in the modern era
Authors: Laveneziana Pierantonio , Di Paolo Marcello , Palange Paolo 
Published: January 2021

Cardiopulmonary exercise testing (CPET) has long been used as diagnostic tool for cardiac diseases. During recent years CPET has been proven to be additionally useful for 1) distinguishing between normal and abnormal responses to exercise; 2) determining peak oxygen uptake and level of disability; 3) identifying factors contributing to dyspnoea and exercise limitation; 4) differentiating between ventilatory (respiratory mechanics and pulmonary gas exchange), cardiovascular, metabolic and peripheral muscle causes of exercise intolerance; 5) identifying anomalies of ventilatory (respiratory mechanics and pulmonary gas exchange), cardiovascular and metabolic systems, as well as peripheral muscle and psychological disorders; 6) screening for coexistent ischaemic heart disease, peripheral vascular disease and arterial hypoxaemia; 7) assisting in planning individualised exercise training; 8) generating prognostic information; and 9) objectively evaluating the impact of therapeutic interventions.As such, CPET is an essential part of patients' clinical assessment. This article belongs to the special series on the “Ventilatory efficiency and its clinical prognostic value in cardiorespiratory disorders”, addressed to clinicians, physiologists and researchers, and aims at encouraging them to get acquainted with CPET in order to help and orient the clinical decision concerning individual patients.
Feasibility and integration of an intensive emergency pediatric care curriculum in Armenia
Authors: Baghdassarian Aline , Best Al M. , Virabyan Anushavan , Alexanian Claire , Shekherdimian Shant , Santen Sally A. , Simonyan Hambartzum 
Published: January 2021

Abstract
Background
Emergency pediatric care curriculum (EPCC) was developed to address the need for pediatric rapid assessment and resuscitation skills among out-of-hospital emergency providers in Armenia. This study was designed to evaluate the effectiveness of EPCC in increasing physicians’ knowledge when instruction transitioned to local instructors. We hypothesize that (1) EPCC will have a positive impact on post-test knowledge, (2) this effect will be maintained when local trainers teach the course, and (3) curriculum will satisfy participants.

Methods
This is a quasi-experimental, pre-test/post-test study over a 4-year period from October 2014‑November 2017. Train-the-trainer model was used. Primary outcomes are immediate knowledge acquisition each year and comparison of knowledge acquisition between two cohorts based on North American vs local instructors. Descriptive statistics was used to summarize results. Pre-post change and differences across years were analyzed using repeated measures mixed models.

Results
Test scores improved from pretest mean of 51% (95% CI 49.6 to 53.0%) to post-test mean of 78% (95% CI 77.0 to 79.6%, p < 0.001). Average increase from pre- to post-test each year was 27% (95% CI 25.3 to 28.7%). Improvement was sustained when local instructors taught the course (p = 0.74). There was no difference in improvement when experience in critical care, EMS, and other specialties were compared (p = 0.23). Participants reported satisfaction and wanted the course repeated. In 2017, EPCC was integrated within the Emergency Medicine residency program in Armenia.

Discussion
This program was effective at impacting immediate knowledge as well as participant satisfaction and intentions to change practice. This knowledge acquisition and reported satisfaction remained constant even when the instruction was transitioned to the local instructors after 2 years. Through a partnership between the USA and Armenia, we provided OH-EPs in Armenia with an intensive educational experience to attain knowledge and skills necessary to manage acutely ill or injured children in the out-of-hospital setting.

Conclusions
EPCC resulted in significant improvement in knowledge and was well received by participants. This is a viable and sustainable model to train providers who have otherwise not had formal education in this field.