bluuebunny/crossref_metadata_2025_split huggingface dataset:
Situação dos medicamentos biológicos no Brasil
Authors: Mendonça Gabriel Duarte , Passos Márcia Maria Barros dos , Miguel Ângelo Samir Melim , Souza Theo Luiz Ferraz de 
Published: December 2020

Medicamento biológico é aquele que possui princípio ativo de origem biológica com atividade terapêutica conhecida. Esta classe de produtos inclui várias categorias de medicamentos ordenados de acordo com a sua tecnologia de obtenção. São medicamentos largamente utilizados no país e constituem um mercado em potencial expansão. O objetivo deste trabalho foi analisar a situação dos medicamentos biológicos no Brasil, no contexto da Assistência Farmacêutica. Trata-se de um estudo descritivo exploratório a partir da busca de informações na Relação Nacional de Medicamentos Essenciais (RENAME), nas bases de dados: Scielo, Periódico capes, Visalegis e website do Instituto Nacional da Propriedade Intelectual (INPI), para consulta de patentes depositadas, e website da Agência Nacional de Vigilância Sanitária (Anvisa) para as regulamentações pertinentes ao registro de tais medicamentos. Os resultados indicaram a presença de 78 medicamentos biológicos (16%) do total de medicamentos integrantes da RENAME 2017, que integram todos os Componentes da Assistência Farmacêutica: Básico, Estratégico e Especializado. Foi verificado que na sua maioria estes medicamentos são importados ou possuem apenas as etapas de embalagem pelas empresas nacionais. Adicionalmente, a presença ínfima de biossimilares foi observada, mesmo para aqueles medicamentos cuja patente já caiu em caducidade há muito tempo. Por fim, os dados apontam uma grande dependência tecnológica e produtiva do Brasil em relação ao mercado internacional de medicamentos biológicos, gerando um grande impacto financeiro, principalmente nos componentes estratégicos e no financiamento da Assistência Farmacêutica no Brasil.
Improving the Speaking Skill by Vlog As Learning Media for Teaching Long Functional Text For Eighth Grade Students at SMPN 17 Medan
Authors: Br. Batubara Khairunnisa , Helena Natali Christine 
Published: December 2020

This research was aimed to develop Video Blog as media of speaking in teaching long functional text for eighth grade students at SMPN 17 Medan. This research applied Research and Development (R&D) model proposed by Gall, Gall and Borg (2003) through six procedures: gathering data and information, conducting need analysis, designing, expert validating, revising, and producing final product. The subjects of this research were 30 students of eighth grade of SMPN 17 Medan. The instruments of collecting data were the teacher’s lesson plan, teacher’s interview and students’ questionnaires result. The data were analyzed by using descriptive analysis. The product has been validated by two experts. The assessment from the first expert was 4,5 or 91,3% while the assessment from the second expert was 4,6 or 93%. Based on the experts’ judgment result, the research showed that: The Video Blogs were eligible and valid as learning media in teaching and learning speaking long functional text for eighth grade students at SMPN 17 Medan. Furthermore, the video blogs give many benefits for students, such as to improve their speaking, make them enjoy and easier to speak long functional text. It means that the vlog media development was appropriate for the eighth grade students of SMPN 17 Medan.
Editorial
Authors: Sarkhel Sujit 
Published: December 2020

Over the last two decades, Bengal Journal of Psychiatry has been regularly publishing peer-reviewed articles in psychiatry and allied disciplines. Carrying the legacy further, we have undertaken several important steps over the last one-year to increase the presence of the journal in the Indian psychiatry literature scenario. The long awaited first step in this direction was to acquire an ISSN number, which has been accomplished a couple of months back. Development of a website for the journal along with archiving of past issues is also under progress. In the coming years, we hope to extend the indexing process of the journal that will increase the impact even further. I seek active encouragement and co-operation of all the members of West Bengal branch of the Indian Psychiatric Society in making this effort a success.
Paroxetine induced bruxism, treated with Buspirone : An unexplored entity
Authors: Chatterjee Seshadri Sekhar , Maji Arnab , Mallik Nitu 
Published: December 2020

SSRI are the widely prescribed first line drugs for depression and as depression very commonly presents with insomnia SSRI are good at improving the sleep problems also. But though rare the occurrence of sleep related side effects like bruxism,it may cause significant distress and cause of nonadherence which easily may be overlooked. In this case we report a case of Paroxetine induced bruxism and subsequently treated with withdrawing the drug and buspirone. Though the aetiology of such bruxism remained unclear, the imbalances in dopaminergic and serotonergic activities in the central nervous system is mostly implicated.Key Words : Bruxism, Escitalopram, Parafunctional activity, Selective Serotonin Reuptake Inhibitors
Early mortality and mental illness: ‘Fatal’ Discrimination
Authors: Das Anindya , Rao Mohan , Daniel Mercian 
Published: December 2020

Worldwide research has provided evidence of premature death in people with mental illness (as compared to the general population). Moreover, in recent decades, the mortality gap between the preceding two groups has not shown any decline even in countries with the most accessible/responsive health systems. This essay considers mortality to be influenced by a multiplicity of factors, many of which, in addition, influence the rate of occurrence and recovery from mental illnesses. The essay examines these factors and analyses them through the lens of structural discrimination (defined as institutional and social structures that perpetuate norms, practices and behavior that deny opportunities/rights to others, often members of a minority). The implications for India in this regard are also reflected upon.
The Psychology of Terrorism: Understanding and Implication for Policies
Authors: Bhattacharyya Bhargavi Chatterjea 
Published: December 2020

Compared with general public, terrorists do not exhibit unusually high rates of clinical psychopathology, irrationality, or personality disorders. The backgrounds of the terrorists are very diverse and there is no one set profile. In fact, barring lone wolf terrorism, there does not seem to be much link with personality or psychopathology.
Socio-Demographic, Clinical Correlates and Predictors of Adverse Outcome in Substance Use Disorder (Sud) Patients Attending the De-Addiction Clinic of a Tertiary Care Hospital in Eastern India
Authors: Mukhopadhyay Sikha , Biswas Parthasarathy 
Published: December 2020

Substance Use Disorder (SUD) is a serious public health problem in India. The present study was planned to study the socio-demographic, clinical correlates and predictors of adverse outcomes in all new patients attending the De-addiction clinic in a tertiary hospital in Eastern India. All new patients visiting the De-addiction clinic were assessed and interviewed. Four groups were made viz Alcohol, Opioid, Cannabinoid and Other SUDs. A total of 200 patients were included in the study, of whom majority were males. A positive family history of substance use was evident in 44.1% of the patients in the Cannabinoid group. The mean duration of use was 180.87 ± 95.64 for the alcohol group, 78.70 ± 66.41 for the opioid group, 94.0 ± 85.70 for the Cannabinoid group, 104.2 ± 79.37 for other SUDs. The most common substance used was alcohol (n=117). Our findings suggest that the initiation of substance use occurs during late teen age years and early 20s in case of Opioid and Cannabinoid group and in case of Alcohol group in their early 30s. In our study, poor social support correlated with family complications, marital complications and social complications. Motivation clearly and significantly correlated with financial, family, marital and social complications suggesting that motivation to leave alcohol/drugs is influenced by these factors. The motivation level influenced follow-up rates with poor to superficial motivation predicting poorer follow up rates. On the other hand good and fair motivation correlated with increased adherence to attending Group therapy. Motivation to leave drugs/alcohol correlated with drop-out & relapse rates with poorer outcomes in form of relapses and drop out related to poor motivation to leave drugs. Financial security in form of employment is critical for adherence to treatment and follow-up rates which in turn influences recovery and rehabilitation. Motivation is cornerstone to relapses and management of motivation enhancement and adherence to treatment can reduce relapses.
Rethinking a dilemma in psychiatric practice
Authors: Chatterjee Debashis 
Published: December 2020

Psychiatry differs from all other medical disciplines in one aspect. Every psychiatric practitioner has to face a particular ethical dilemma in her/his daily professional work. The ethical issue arises in the context of treatment and care of a person afflicted with some mental illness and it arises because the patient’s view of and choice regarding his/her own condition and the view and opinion of the professional differ and are contrasting. The conflict arises from difference of opinion between the service user and experiencer of suffering on one hand and the clinician as knowledge-powerholder.
Editorial
Authors: Sarkhel Sujit 
Published: December 2020

In this special issue, we have tried to highlight the contributions of the ‘Luminaries of Bengal Psychiatry’ whose efforts over the years has brought Indian Psychiatry to what it is today. The current generation has a tendency to look for all achievers and achievements beyond their own place. With passing time, the contributions of these individuals are likely to be forgotten. Hence, it is our responsibility to highlight the achievements of these great souls whose legacy is being carried on today in various aspects - teaching, academic writing, clinical work or community services. I am really indebted to the contributors who have toiled very hard in such a short period of time to make this special issue see the light of the day!
Impacto da Cirurgia Bariátrica na Imagem Corporal e Saúde Mental
Authors: Simões Gisela , Brandão Isabel 
Published: December 2020

Introdução: A imagem corporal (IC), na sequência do recurso a cirurgia bariátrica (CB) e da experiência rápida e massiva de perda de peso inerente, poderá sofrer alterações como satisfação, insatisfação ou distorção. Esta monografia pretende explorar a concepção da IC do doente obeso e a sua experiência perante o próprio corpo após recurso a CB, bem como o reflexo desta intervenção ao nível da saúde mental. Aditivamente, este estudo esclarece ainda a potencial dissociação entre o tempo de adaptação físico-metabólica e de adaptação psicológica, o recurso a técnicas de correção estética após CB, bem como as motivações na base da opção por estratégias cirúrgicas.
Metodologia: A aquisição da informação bibliográfica foi conduzida através de uma pesquisa realizada nas plataformas PubMed e SCOPUS, partindo da seguinte combinação de termos: body image e bariatric surgery. Estudos obtidos nos últimos 5 anos foram analisados, correspondendo a investigações conduzidas ou tendo por base a população obesa.
Resultados: A maioria dos estudos corrobora o efeito benéfico da CB ao nível da concepção da IC, contudo, a existência de resultados insatisfatórios, melhorias limitadas no tempo ou de repercussões negativas no domínio da saúde mental têm também vindo a ser reportadas. A transformação psicológica implícita pode, inclusive, tomar um ritmo de desenvolvimento discrepante da rápida e simultânea transformação físico-metabólica. A evidência do benefício de recurso a cirurgia estética corretora, como lifting corporal (LC), tem-se apresentado cada vez mais consistente, associado a melhorias psicossociais generalizadas. No entanto, as motivações que servem de base ao recurso a CB e LC subsequente permanecem pouco esclarecidas
Conclusões: As mudanças causadas pela CB poderão expor o doente a tensões nunca antes por si experienciadas ou projectadas antes da cirurgia; assim, o seguimento a longo prazo do doente pós-bariátrico por psicologia e/ou psiquiatria assume-se uma etapa de avaliação imprescindível.
Advance Care Planning for People with Schizophrenia and an End‑of‑Life Situation: A Qualitative Systematic Review
Authors: Góis José 
Published: December 2020

Introdução: As pessoas com esquizofrenia têm um risco acrescido de mortalidade ao mesmo tempo que recebem menos cuidados paliativos, dos quais o planeamento antecipado de cuidados éum componente essencial. O objetivo desta revisão éreunir as provas disponíveis relativamente ao planeamento antecipado de cuidados em contexto paliativo em pessoas com esquizofrenia, os seus obstáculos e as boas práticas a serem seguidas.
Método: Revisão sistemática da literatura qualitativa ao longo dos últimos 20 anos relativamente à utilização de planeamento antecipado de cuidados em cuidados paliativos ou de fim de vida em pessoas com esquizofrenia.
Resultados: Sete artigos foram incluídos na revisão. Por análise temática foram identificados cinco temas, nomeadamente, a capacidade de decisão em doenças mentais graves, as particularidades do planeamento antecipado de cuidados na pessoa com esquizofrenia, as características da esquizofrenia que afetam o planeamento antecipado dos cuidados, comunicação e formação, e a multidisciplinaridade e continuidade de cuidados.
Conclusão: É urgentemente necessária mais investigação nesta área. Os pacientes enfrentam obstáculos relacionados com a sua doença mental, desconforto e dúvida por parte dos profissionais de saúde e falta de figuras de apoio. Uma abordagem multidisciplinar e colaborativa, a formação e o reconhecimento da capacidade inerente dos pacientes para fazerem escolhas e terem discussões eficazes sobre o seu estado de saúde, facilita o processo de planeamento antecipado de cuidados.
ARCH GARCH METHOD OF FORECASTING CONSUMER PRICE INDEX (CPI) IN SEMARANG
Authors: Kustiara Sri , Nur Indah Manfaati , Utami Tiani Wahyu 
Published: December 2020

Indeks Harga Konsumen (IHK) merupakan salah satu indikator ekonomi penting yang dapat memberikan informasi mengenai perkembangan harga barang/jasa yang dibayar oleh konsumen di suatu wilayah. Penghitungan IHK ditujukan untuk mengetahui perubahan harga dari sekelompok tetap barang atau jasa yang umumnya dikonsumsi oleh masyarakat setempat. Dalam metode yang digunakan dalam pemodelan data runtun waktu memiliki syarat khusus yaitu yang teridentifikasi efek heteroskedastisitas. Tujuan dari penelitian ini adalah untuk mengetahui model terbaik peramalan periode berikutnya serta hasil prediksi periode mendatang. Variabel yang digunakan adalah data Indeks Harga Konsumen dalam bulan. Sehingga untuk mengatasi permasalahan pada data penelitian ini digunakan metode Autoregressive Conditional Heteroscedasticity Generalized Autoregressive Conditional Heteroscedasticity (ARCH GARCH). Hasil dari penelitian ini didapatkan metode ARCH GARCH model terbaik yang digunakan adalah ARIMA (1,1,1)~GARCH (1,0). Dengan prediksi dari volatilitas dengan nilai standar deviasi 0.98283514 diperoleh prediksi volatilitas terendah sebesar 0.9632546 dan prediksi volatilitas tertinggi sebesar 0.9980155.
“This Generation”: Reconsidering Mark 13:30 in Light of Eschatological Expectations in Second Temple Judaism
Authors: Winn Adam 
Published: December 2020

Abstract
Mark 13:30 has received significant interpretive attention in the history of NT scholarship. Much of the attention given to this text finds its origin in concern over whether Jesus has erred in his prediction of his parousia and the culmination of the eschaton. As a way forward in resolving this long recognized problem of Jesus making an errant prophecy, this study considers other interpretive difficulties presented by Mark 13:30, including its tension with Mark 13:32 and its reception by the Matthean and Lukan Evangelists. As a means of addressing these difficulties, the study, like many before it, reconsiders the meaning of γενεὰ in Mark 13:30. Unlike previous studies, this study considers the “generation” concept within the eschatological expectations of Second Temple Judaism. The meaning of γενεὰ that emerges from this analysis not only resolves the various interpretive problems of Mark 13:30 but also provides significant coherence to the entirety of Mark 13.
Reseña de Belinda Palacios, Entre la historia y la ficción: estudio y edición de “Historia del Huérfano” de Andrés de León (1621), un texto inédito de la América colonial
Authors: Serés Guillermo 
Published: December 2020

Reseña de Belinda Palacios, Entre la historia y la ficción: estudio y edición de “Historiadel Huérfano” de Andrés de León (1621), un texto inédito de la Américacolonial.
As veredas do ordenamento jurídico da Educação Infantil do Campo: um olhar sobre os jogos e brincadeiras
Authors: Barbosa Elizabete Pereira , Almeida Luciana Freitas de Oliveira 
Published: December 2020

O presente artigo tem como objetivo analisar as contribuições dos jogos e brincadeiras na Educação Infantil do Campo nas escolas municipais dos distritos de Feira de Santana, estado da Bahia. Este trabalho baseia-se em pesquisa empírica e bibliográfica. Os referenciais teóricos estão fundamentados à luz do Coletivo de Autores (1992); Kischimoto(1993, 2007), no ordenamento jurídico (BRASIL, 1988, 1998) e nos documentos oficiais como: Lei de Diretrizes e Bases da Educação nº 9.394/96 (BRASIL 1996). A pesquisa revela que os jogos e brincadeiras são trabalhados prioritariamente como estratégia metodológica nas aulas de Educação Física e os professores compreendem a importância do conteúdo para o desenvolvimento integral das crianças.
Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation
Authors: Zhao Xiaoliang , Kim In‐Kyu , Kallakury Bhaskar , Chahine Joeffrey J. , Iwama Eiji , Pierobon Mariaelena , Petricoin Emanuel , McCutcheon Justine N. , Zhang Yu‐Wen , Umemura Shigeki , Chen Vincent , Wang Changli , Giaccone Giuseppe 
Published: December 2020

Platinum‐based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1) plays a key role in DNA damage response to chemotherapeutic drugs, we explored the mechanisms of acquired drug resistance to the Chk1 inhibitor prexasertib in SCLC. We established prexasertib resistance in two SCLC cell lines and found that DNA copy number, messengerRNA (mRNA) and protein levels of the cell cycle regulator Wee1 significantly correlate with the level of acquired resistance. Wee1 small interfering RNA (siRNA) or Wee1 inhibitor reversed prexasertib resistance, whereas Wee1 transfection induced prexasertib resistance in parental cells. Reverse phase protein microarray identified up‐regulated proteins in the resistant cell lines that are involved in apoptosis, cell proliferation and cell cycle. Down‐regulation of CDK1 and CDC25C kinases promoted acquired resistance in parental cells, whereas down‐regulation of p38MAPK reversed the resistance. High Wee1 expression was significantly correlated with better prognosis of resected SCLC patients. Our results indicate that Wee1 overexpression plays an important role in acquired resistance to Chk1 inhibition. We also show that bypass activation of the p38MAPK signaling pathway may contribute to acquired resistance to Chk1 inhibition. The combination of Chk1 and Wee1 inhibitors may provide a new therapeutic strategy for the treatment of SCLC.
Molecular profiling of long‐term responders to immune checkpoint inhibitors in advanced non‐small cell lung cancer
Authors: Frigola Joan , Navarro Alejandro , Carbonell Caterina , Callejo Ana , Iranzo Patricia , Cedrés Susana , Martinez‐Marti Alex , Pardo Nuria , Saoudi‐Gonzalez Nadia , Martinez Debora , Jimenez Jose , Sansano Irene , Mancuso Francesco M. , Nuciforo Paolo , Montuenga Luis M. , Sánchez‐Cespedes Montse , Prat Aleix , Vivancos Ana , Felip Enriqueta , Amat Ramon 
Published: December 2020

Immunotherapy has transformed advanced non‐small cell lung cancer (NSCLC) treatment strategies and has led to unprecedented long‐lasting responses in some patients. However, the molecular determinants driving these long‐term responses remain elusive. To address this issue, we performed an integrative analysis of genomic and transcriptomic features of long‐term immune checkpoint inhibitors (ICIs)‐associated responders. We assembled a cohort of 47 patients with NSCLC receiving ICIs that was enriched in long‐term responders [>18 months of progression‐free survival (PFS)]. We performed whole‐exome sequencing from tumor samples, estimated the tumor mutational burden (TMB), and inferred the somatic copy number alterations (SCNAs). We also obtained gene transcription data for a subset of patients using Nanostring, which we used to assess the tumor immune infiltration status and PD‐L1 expression. Our results indicate that there is an association between TMB and benefit to ICIs, which is driven by those patients with long‐term response. Additionally, high SCNAs burden is associated with poor response and negatively correlates with the presence of several immune cell types (B cells, natural killers, regulatory T cells or effector CD8 T cells). Also, CD274 (PD‐L1) expression is increased in patients with benefit, mainly in those with long‐term response. In our cohort, combined assessment of TMB and SCNAs burden enabled identification of long‐term responders (considering PFS and overall survival). Notably, the association between TMB, SCNAs burden, and PD‐L1 expression with the outcomes of ICIs treatment was validated in two public datasets of ICI‐treated patients with NSCLC. Thus, our data indicate that TMB is associated with long‐term benefit following ICIs treatment in NSCLC and that TMB, SCNAs burden, and PD‐L1 are complementary determinants of response to ICIs.