bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the fate of natural organic matter at a drinking water treatment plant in South Africa using optical spectroscopy and chemometric analysis
Authors: Welldone Moyo  , Nhamo Chaukura  , Machawe M Motsa  , Titus AM Msagati  , Bhekie B Mamba  , Sebastiaan GJ Heijman  , Thabo TI Nkambule  
Published: January 2020

The removal dynamics of biodegradable dissolved organic carbon (BDOC) and natural organic matter (NOM) polarity fractions at a water treatment plant (WTP) in South Africa was studied using UV-Vis absorbance, fluorescence excitation-emission matrix, and two-dimensional synchronous fluorescence spectroscopy (SFS). This study gave insights into the transformation of NOM due to treatment processes. The objectives of the study were: (i) to use chemometric analysis and two-dimensional SFS correlations to investigate the evolution of NOM arising from treatment processes, and (ii) to access the chemical profile dynamics of polarity and BDOC fractions throughout the treatment train. The UV254 absorbance, which indicates aromaticity, reduced by 45% along the WTP. Gaussian fitting of UV-Vis data showed a decreasing trend in intensity and number of bands along the treatment process. The removal efficiency of NOM components followed the order: humic-like (HL) > tyrosine-like (TYL) > fulvic-like (FL) > tryptophan-like (TPL) > microbial-like (MBL). At the source, the relative distribution of the hydrophobic (HPO), hydrophilic (HPI), and transphilic (TPI) fractions was 45%, 31%, and 24%, respectively. The HPI was recalcitrant to treatment, and the TYL component of the HPI fraction was conjectured to be a disinfection byproduct limiting reagent. The HL and FL components of the BDOC fraction were the major substrates for bacterial growth. According to two-dimensional-SFS correlation, TYL, TPL, and MBL varied concurrently across the treatment stages. Used for the first time in South Africa, the robustness of a multi-dimensional approach of optical methods coupled with chemometric tools for the assessment of the fate of NOM along the treatment processes was revealed by this study.
Lysozyme in the treatment of non-infectious sore throat
Authors: Glamočlija Una , Mehić Meliha , Šukalo Aziz , Tanović Avdić Amna , Džananović Jaganjac Jasna 
Published: January 2020

Sore throat is a common reason for seeking medical help [1]. It can have infectious and non-infectious aetiology [2]. The term “sore throat” is usually associated with an infectious agent (bacteria, viruses, and less commonly fungi) [1,3,4]. The terms “throat discomfort“,“throat irritation“ or “functional dysphonia due to the occupational diseases“ (which represents voice disorder) are often used in the same sense as a non-infectious sore throat [2,3]. It is identified by the exclusion of infectious aetiology symptoms accompanied by persistent sore throat symptoms (tingling and scratching sensation in the throat, hoarseness or muffled voice, foreign body sensation in the throat, coughing, difficulty in swallowing accompanied by pain) [2,5].
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Evaluasi Inverse Kinematics untuk Robot Quadruped Menggunakan Sensor Accelerometer
Authors: Nasrudin Ahmad Iqbal , Anam Khairul , Prawira N M. Agung 
Published: January 2020

Quadruped robot is one of the types of robots that move using legs 4 compiled by some of the servo motor as a driving force on each foot ft the DOF is used. However, problems arise when this robot is confronted on the inclined plane, because the burden is borne out every servo motor on the feet will be different, so can make a fast servo motor damaged. This research was conducted on the design of the quadruped robot system for stability on the inclined plane using the accelerometer sensor and the application of the inverse kinematics method with PID control of Ziegler-Nichols. The results of tests obtained response robots in stabilizing the body when faced with the inclined plane with some degree of slope of the pitch and roll. In this research was conducted some test for quadruped robot: static Testing robot against the angel of the pitch in the standby retrieved response average robot in stabilizing the body is 245 ms, static Testing robot against the angle of roll in standby retrieved response average robot in stabilizing the body is 280 ms, dynamic Testing robot against the roll and pitch in standby retrieved response average robot in stabilizing the body is 8 seconds, Static Testing robot to stabilizing the body against the angel of roll in running the largest robot oscillations obtained 10 degrees, dynamic Testing robot to stabilizing the body against the angle of roll in run retrieved response average robot in stabilizing the body is 490 ms.
Invirtiendo el aula en asignaturas de Gestión de Empresas utilizando diferentes herramientas metodológicas
Authors: Jimenez Rocio Martinez , Ruiz Jiménez Carmen 
Published: January 2020

En los últimos años hemos vivido un cambio importante en el ámbito universitario, que ha provocado que sean necesarias nuevas metodologías docentes en las que el estudiante adquiera un rol mucho más activo y responsable de su propio aprendizaje. En esta línea nos encontramos con un nuevo modelo de enseñanza-aprendizaje como es el aula invertida o flipped classroom (Bergmann y Sams, 2012). Esta metodología supone que el tiempo de clase en el aula se dedica a aplicar, experimentar, indagar, etc.; esto es, a trabajar los niveles más altos de la taxonomía de Bloom. Para ello, el profesorado debe elaborar diferentes prácticas o actividades que sirvan al estudiante para reforzar lo aprendido previamente en casa y que, siguiendo a Santiago y Bergmann (2018) pueden incluirse dentro de, entre otras, las siguientes categorías: enseñanza entre iguales, aprendizaje basado en proyectos, estudios de casos, simulaciones, role-playing, aprendizaje cooperativo y gamificación.
En este trabajo presentamos la valoración realizada por los estudiantes sobre las diferentes herramientas utilizadas al invertir el aula en dos asignaturas relacionadas con la gestión empresarial. Más concretamente, analizamos el grado de interés y diversión que han suscitado en ellos, así como en qué medida cada una de estas técnicas les ha hecho participar más activamente, ha mejorado la comunicación con los compañeros y con el profesorado y ha contribuido a una mayor comprensión de las asignaturas. Los resultados muestran que las tres metodologías mejor valoradas por los estudiantes son: la gamificación, el role-playing y el aprendizaje basado en proyectos.
En este trabajo presentamos la valoración realizada por los estudiantes sobre las diferentes herramientas utilizadas al invertir el aula en dos asignaturas relacionadas con la gestión empresarial. Más concretamente, analizamos el grado de interés y diversión que han suscitado en ellos, así como en qué medida cada una de estas técnicas les ha hecho participar más activamente, ha mejorado la relación con los compañeros y con la profesora y ha contribuido a una mayor comprensión de la asignatura. Los resultados muestran que las tres metodologías mejor valoradas por los estudiantes son: la gamificación, el role-playing y el aprendizaje basado en proyectos.
Dos experiencias de aplicación del nexo investigación-docencia en Ciencias Sociales: la perspectiva del docente universitario
Authors: Cámara Antonio D. , Barros Rodríguez Francisco , Martínez Carrión José Miguel , Candela Martínez Begoña 
Published: January 2020

Hay al menos tres planos desde los que el nexo metodológico investigación-docencia puede contemplarse como factor estratégico en el proceso de aprendizaje universitario: 1) el de la productividad y competitividad científico-académica a nivel institucional; 2) el de la capacitación individual de cara a la integración en mercados laborales crecientemente competitivos y 3) el de la mejora de la eficiencia en el planteamiento de proyectos y gestión de recursos en los sectores público y privado. En los tres planos resulta evidente la contribución potencial de una docencia interactiva y experimental que ceda protagonismo a los estudiantes en la consecución de competencias.
El objetivo de este trabajo es presentar y discutir dos experiencias inspiradas en estas metodologías que se desarrollan en asignaturas de grados de Ciencias Sociales en las Universidades de Jaén y Murcia.
En torno a dichas experiencias se comentan algunos recursos de aprendizaje aplicados en distintas fases del curso y con distintas finalidades: fundamentos de diagnóstico a partir de la resolución de problemas de investigación, asimilación práctica de conceptos, técnicas de generación y de recopilación de información, y elaboración de soportes mediáticos para la presentación y difusión de resultados de investigación. Finalmente se presentan y discuten, desde el punto de vista docente, algunos resultados de aprendizaje obtenidos, las principales dificultades detectadas en la aplicación de la metodología y los avances obtenidos en las competencias establecidas originalmente.
El objetivo de este trabajo es presentar y discutir dos experiencias inspiradas en estas metodologías que se desarrollan en asignaturas de grados de Ciencias Sociales en las Universidades de Jaén y Murcia.
En torno a dichas experiencias se comentan algunos recursos de aprendizaje aplicados en distintas fases del curso y con distintas finalidades: fundamentos de diagnóstico a partir de la resolución de problemas de investigación, asimilación práctica de conceptos, técnicas de generación y de recopilación de información, y elaboración de soportes mediáticos para la presentación y difusión de resultados de investigación. Se comentan asimismo los principales condicionantes a los que se hace frente en el desarrollo de los proyectos. Finalmente se presentan y discuten algunos resultados de aprendizaje obtenidos, las dificultades detectadas en la aplicación de la metodología y los avances obtenidos en las competencias establecidas originalmente.
Contrast-induced nephropathy in patients with acute coronary syndrome with ST-segment elevation: risk factors and prognosis
Authors: Arsenicheva O. V. , Shchapovа N. N. 
Published: January 2020

Objective: to study the risk factors for acute renal injury, the dynamics of renal function and prognosis in patients with acute coronary syndrome with ST-segment elevation (STEACS) with contrast-induced nephropathy (CIN) after primary percutaneous coronary intervention (PCI).Materials and methods. We studied 20 patients with STEACS, who developed СIN after PCI (follow-up group), and 98 patients with STEACS without СIN (comparison group). All patients were measured plasma creatinine level and glomerular filtration rate by the formula CKD-EPI before and 48 hours after PCI. CIN was detected with an increase in creatinine levels in the blood by more than 26.5 µmol / l from the baseline 48 hours after administration of radiopaque drug (RCP). Endpoints were evaluated at the hospital stage and within 12 months after PCI.Results. CIN after PCI occurred in 16.9 % of patients with STEACS. Among patients with СIN, persons aged over 75 years (60 %), with diabetes mellitus (45 %), chronic kidney disease (75 %), postinfarction cardiosclerosis (50 %), chronic heart failure of functional class III–IV (80 %), developed acute heart failure T. Killip III–IV (90 %) were significantly more often observed. The left ventricular ejection fraction was lower in patients with СIN (p <0.05). The average increase in plasma creatinine 48 hours after PCI was higher in the follow-up group (p <0.05). In patients with СIN more often, than without СIN, three-vascular lesions of the coronary bed were detected (65 and 25.5 % respectively, p <0.001). The same trend was observed, when assessing the average number of coronary artery stenoses, the number of implanted stents and the volume of RCP used. Patients with СIN, than without СIN, were longer in hospital (12.1 ± 0.96 and 10.2 ± 1.11 days respectively, p <0.05) and more often needed re-hospitalization within 12 months after PCI (34 and 4.1 % respectively, p <0.05).Summary. CIN in patients with STEACS after primary PCI was more likely to develop, if the following symptoms were present: age over 75 years, diabetes mellitus, chronic heart failure, post-infarction cardiosclerosis, chronic kidney disease, low ejection fraction of the left ventricle, initially high creatinine level, development of acute heart failure, trisovascular coronary lesion and multiple coronary stenting. The duration of hospital stay and the frequency of re-hospitalizations within a year after PCI significantly increased in patients in the CIN group.
Paraneoplastic myelitis in a patient with non-hodgkin lymphoma
Authors: Guseynova M. N. , Zaslavskii L. G. , Skornyakova E. A. 
Published: January 2020

Objective: description of a clinical case of the development of longitudinally spread transverse myelitis in a young woman suffering from nonHodgkin’s lymphoma (follicular, 1 degree, IIIA stage, complete remission from February 2017). This is a rare, significant case in clinical practice for both residents and neurologists, and the case is under discussion. It requires certain scientific studies in the search for specific antionkoneural antibodies or a more detailed study of the already known. It is necessary to introduce these studies into laboratory practice in Russia, which would help to accelerate the diagnosis of paraneoplastic myelitis.Materials and methods. Patient B., 30 years old, has been suffering non-Hodgkin’s lymphoma since February 2016 (follicular, I degree, IIIA stage, complete remission from February 2017), receives infusions of Rituximab with a dose of 600 mg once in 2 months, the subacute developed pronounced lower spastic paraparesis. In November 2018, suddenly, against the background of complete well-being, weakness and numbness of the legs appeared. The patient asked for help at the Center for Multiple Sclerosis on 11.17.2018, then she was hospitalized and examined. Patient B. received a pulse therapy with methylprednisolone 1000 mg intravenously № 5. Discharged with positive dynamics with a diagnosis of Demyelinating CNS disease, unspecified. Acute protracted transverse myelitis (LETM), EDSS = 3.5 points. On December 13, due to the increase in spacity and leg weakness, she was urgently hospitalized in the neurological department of the Clinical Hospital.Results. After the completion of laboratory and instrumental examination, the condition was regardedby us as paraneoplastic myelitis. Relapse of lymphoma was ruled out. The treatment was carried out: pulse therapy with methylprednisolone, Plasmapheresis and intravenous administration of IgG (Privigen) with a distinct positive dynamics.Conclusion. This clinical observation allowed us to become more familiar with paraneoplastic syndromes and, in particular, with paraneoplastic myelitis. In the clinical situation previously described, we encountered a number of features: longitudinally extensive transverse myelitis developed without relapse of lymphoma, progressed rapidly, there was no response to treatment (glucocorticosteroids, plasmapheresis, Rituximab). All these signs and MRI data of the cervical and thoracic spine (a symmetric hyper-intensive signal from level CII to level ThXI, mainly involving the central spinal cord T2 MRI mode) testified in favor of the paraneoplastic etiology of longitudinally extensive transverse myelitis.
Teoría de la felicidad laboral superior para empresarios y directores ejecutivos de América Latina
Authors: Collazos Fajardo Carlos , Blandón Blandón Gloria Nancy 
Published: January 2020

Este artículo de investigación es el resultado del resultado obtenido del trabajo titulado: Hacia una perspectiva teórica de la felicidad ocupacional para la administración universitaria y el lugar de trabajo. Esta propuesta teórica se desarrolla en la ciudad de Armenia Quindío Colombia, con una metodología de enfoque cualitativo que tiene en cuenta la Teoría Fundamentada (Teoria Fundamentada), con respecto a las narrativas experimentales proporcionadas por entrevistas perspicaces de varias personas de la comunidad universitaria, adjuntas con diferentes tipos de compromiso con una institución de naturaleza pública, denominada: Universidad del Quindío. El objetivo de esta pieza consistió en: construir una teoría sobre la Felicidad Ocupacional para las organizaciones y el lugar de trabajo a través de narraciones dadas por profesores y asistentes administrativos de la Universidad del Quindío. Para tal efecto, se tuvo en cuenta las contribuciones teóricas de las ciencias de la felicidad y el seguimiento de autores como: Aranda (2016), Cabral (2015), Guisán, (1992), Muchinsky (2004), Seligman (2017), Russell (2005), Schein (1982), Shahar, Tal, (2017) Tolle (2000) y Varela (2014).
En última instancia, esta investigación presenta la construcción teórica sobre la Felicidad ocupacional y presenta una nueva terminología para nombrar a los actores del proceso ocupacional. Del mismo modo, este análisis muestra numerosas recomendaciones dirigidas a empresarios y CEO de diferentes corporaciones. Además, también cubre a las personas talentosas que prestan sus servicios en una empresa y añaden un plan de estudios para orientar los programas de felicidad en las diferentes empresas, instituciones y corporaciones a una escala global.
Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
Authors: Yu Shufang , Wang Shuang , Xie Yanping , Bao Aina , Li Jing , Ye Tingting , Yang Chu , Lin Bin , Yang Minghua 
Published: January 2020

Abstract
Background: Overexpression of Discoidin domain receptor 1(DDR1) is known to enhance the malignancy of breast cancer considerably. This study reports the identification of a potent DDR1 inhibitor, Nilotinib for the treatment of breast cancer. Methods: MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MCF-7 cell lines with low level DDR1 expression by transfecting with plasmids containing by shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin，Vimentin, Snail1 were detected by western blot and immuno-fluorescent staining . Results: Nilotinib against MCF-7 (IC 50 =0.403 μM) and MDA-MB-231 (IC 50 =0.819 μM) and also indicated induced apoptotic cell death after co-cuturing with Nilotinib (500 nM), apoptosis rate is 29.60 % ± 2.19% and 18.75 % ± 2.30% respective ly. Moreover, Nilotinib effectually blocked cellular migration of MCF-7. Interestingly, Knock-down DDR1 could significantly block the migration of breast cancer, meantime the sensitivity of Nilotinib to MCF-7 was reduced. Conclusion: Targeting DDR1 therapeutically could potentially affect survival and influence metabolism in breast cancer, and Nilotinib could as a candidate for the treatment of breast cancer.
Towards an understanding of the burdens of medication management affecting older people: the MEMORABLE realist synthesis
Authors: Maidment Ian , Lawson Sally , Wong Geoff , Booth Andrew , Watson Anne , Zaman Hadar , Mullan Judy , McKeown Jane , Bailey Sylvia 
Published: February 2020

Abstract

Background: More older people are living in the community with multiple diagnoses and medications. Managing multiple medications produces issues of unrivalled complexity for those involved. Despite increasing literature on the subject, gaps remain in understanding how, why and for whom complex medication management works, and therefore how best to improve practice and outcomes. MEMORABLE, MEdication Management in Older people: Realist Approaches Based on Literature and Evaluation, aimed to address these gaps.
Methods: MEMORABLE used realism to understand causal paths within medication management. Informed by RAMESES (Realist And Meta-narrative Evidence Synthesis: and Evolving Standards) guidelines, MEMORABLE involved three overlapping work packages: 1) Realist Review of the literature (24 articles on medication management exploring causality); 2) Realist Evaluation (50 realist-informed interviews with older people, family carers and health and care practitioners, explaining their experiences); and 3) data synthesis and theorising from 1) and 2).
Results: Medication management was viewed from the perspective of ‘implementation’ and structured into five stages: identifying a problem (Stage 1), getting a diagnosis and/or medications (Stage 2), starting, changing or stopping medications (Stage 3), continuing to take medications (Stage 4), and reviewing/reconciling medications (Stage 5).
Three individual stages (1, 3 and 4) are conducted by the older person sometimes with family carer support when they balance routines, coping and risk. Stages 2 and 5 are interpersonal where the older person works with a practitioner-prescriber-reviewer, perhaps with carer involvement.
Applying Normalisation Process Theory, four steps were identified within each stage: 1) sense making: information, clarification; 2) action: shared-decision-making; 3) reflection/monitoring; and 4) enduring relationships, based on collaboration and mutual trust.
In a detailed analysis of Stage 5: Reviewing/reconciling medications, adopting the lens of ‘burden’, MEMORABLE identified five burdens amenable to mitigation: ambiguity, concealment, unfamiliarity, fragmentation and exclusion. Two initial improvement propositions were identified for further research: a risk screening tool and individualised information.
Conclusions: Older people and family carers often find medication management challenging and burdensome particularly for complex regimens. Practitioners need to be aware of this potential challenge, and work with older people and their carers to minimise the burden associated with medication management.
Myocardial ischemia-reperfusion injury alters inflammation-associated gut microbiota
Authors: Kuang Cuifang , Su Lingqin , Qin Manman , Qiu Liang , Yu Jun 
Published: January 2020

Abstract
Background The gut microbiota plays important roles in the development of cardiovascular diseases. However, whether myocardial ischemia–reperfusion (I/R) alters gut microbiota composition and its significance remains unknown. In this work, Sprague–Dawley rats were subjected to left anterior descending coronary artery ligation and reperfusion. The fecal DNA isolated before myocardial ischemia and after reperfusion were analyzed for microbiota changes by high-throughput 16S rDNA sequencing. Results Results showed that compared with the pre-I/R and pre-sham surgery group, I/R and sham surgery significantly increased the relative abundance of the phyla Proteobacteria , and decreased the relative abundance of the phylum Firmicutes . The I/R surgical procedure increased the proportions of phylum Spirochaetes and genus Enterococcus compared to pre-I/R and sham surgery group. Moreover, I/R surgery significantly worsened the infiltration of macrophages into heart tissue compared with sham surgery. Conclusions Taken together, these findings suggested that myocardial I/R altered the gut microbiota profile, which may promote inflammatory cell infiltration in the injured heart.