bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Does Blood-Retinal Barrier Breakdown Relate to Death and Disability in Pediatric Cerebral Malaria?
Authors: MacCormick Ian J C , Barrera Valentina , Beare Nicholas A V , Czanner Gabriela , Potchen Michael , Kampondeni Samuel , Heyderman Robert S , Craig Alister G , Molyneux Malcolm E , Mallewa Macpherson , White Valerie A , Milner Dan , Hiscott Paul , Taylor Terrie E , Seydel Karl B , Harding Simon P 
Published: August 2020

Abstract

Background
In cerebral malaria, the retina can be used to understand disease pathogenesis. The mechanisms linking sequestration, brain swelling, and death remain poorly understood. We hypothesized that retinal vascular leakage would be associated with brain swelling.

Methods
We used retinal angiography to study blood-retinal barrier integrity. We analyzed retinal leakage, histopathology, brain magnatic resonance imaging (MRI), and associations with death and neurological disability in prospective cohorts of Malawian children with cerebral malaria.

Results
Three types of retinal leakage were seen: large focal leak (LFL), punctate leak (PL), and vessel leak. The LFL and PL were associated with death (odds ratio [OR] = 13.20, 95% confidence interval [CI] = 5.21–33.78 and OR = 8.58, 95% CI = 2.56–29.08, respectively) and brain swelling (P &lt; .05). Vessel leak and macular nonperfusion were associated with neurological disability (OR = 3.71, 95% CI = 1.26–11.02 and OR = 9.06, 95% CI = 1.79–45.90). Large focal leak was observed as an evolving retinal hemorrhage. A core of fibrinogen and monocytes was found in 39 (93%) white-centered hemorrhages.

Conclusions
Blood-retina barrier breakdown occurs in 3 patterns in cerebral malaria. Associations between LFL, brain swelling, and death suggest that the rapid accumulation of cerebral hemorrhages, with accompanying fluid egress, may cause fatal brain swelling. Vessel leak, from barrier dysfunction, and nonperfusion were not associated with severe brain swelling but with neurological deficits, suggesting hypoxic injury in survivors.
Multiple sensory modalities in diurnal geckos is associated with the signalling environment and evolutionary constraints
Authors: Kabir Md Shakilur , Venkatesan Radhika , Thaker Maria 
Published: August 2020

Abstract
To be effective, animal signals need to be detectable in the environment, but their development and expression require resources. For multimodal communication, investment in elaborating traits in one modality could reduce the elaboration of traits in other modalities.
In Cnemaspis geckos, chemical signals for conspecific communication pre-dated the evolution of visual signals, allowing us to examine the potential trade-off in signal elaboration and the current habitat associations with signal use. We studied five species of Cnemaspis and quantified visual (patch size, colour characteristics) and chemical (secretory composition) traits in males, as well as key environmental parameters (temperature, humidity, light) in each of their habitats. Within species, we found some trade-off in the elaboration of signals, as the strength of several components in the visual and chemical modalities were negatively associated. Strength of some signal components in each modality was also independently associated with specific environmental parameters that affect their detection (visual traits) and persistence (chemical traits). Specifically, species with larger, brighter, and more saturated colour patches were found in habitats where the brightness and chroma of light were lower. Furthermore, environments with higher substrate temperature and higher relative humidity harboured species that produced secretions with a higher percentage of saturated and aromatic compounds. Thus, the elaboration of multimodal signals in this group of Cnemaspis geckos seem to increase efficiency of communication in the signalling-environment, but the strength of signals in different modalities are constrained by trade-offs in signal expression.
Evaluation and mitigation of the effects of in utero heat stress on piglet growth performance, postabsorptive metabolism, and stress response following weaning and transport
Authors: Maskal Jacob M , Duttlinger Alan W , Kpodo Kouassi R , McConn Betty R , Byrd Christopher J , Richert Brian T , Marchant-Forde Jeremy N , Lay Donald C , Perry Shelbi D , Lucy Matthew C , Safranski Tim J , Johnson Jay S 
Published: August 2020

Abstract
In utero heat stress (IUHS) increases the energy requirements of pigs during postnatal life, and this may compound weaning and transport stress. The study objective was to evaluate and mitigate the negative effects of IUHS following weaning and transport through the provision of a nutrient-dense (ND) nursery diet formulated to meet the greater energy requirements of IUHS pigs during the first 14 d postweaning and transport. Twenty-four pregnant gilts were exposed to thermoneutral (TN; n = 12; 17.5 ± 2.1 °C) or heat stress (HS; n = 12; cycling 26 to 36 °C) conditions for the first half of gestation (day 6 to 59) and then TN conditions (20.9 ± 2.3 °C) until farrowing. Nine TN gilts and 12 HS gilts produced litters. At weaning (16.2 ± 0.4 d), mixed-sex piglets (N = 160; 4.78 ± 0.15 kg body weight [BW]) were transported (loading + transport + unloading) for 11 h 40 min. Following transport, piglets were blocked into pens (n = 4 pigs/pen) by in utero and dietary treatments: in utero thermoneutral (IUTN) + control (C) diet (n = 10 pens), IUTN + ND (n = 10 pens), IUHS + C (n = 10 pens), and IUHS + ND (n = 10 pens). Treatment diets were fed from day 1 to 14 postweaning and transport (period 1), and the C diet was fed to all pigs from day 14 to 35 postweaning and transport (period 2). Production measures were taken in 7 d intervals to calculate average daily gain (ADG), average daily feed intake (ADFI), average daily net energy intake (ADEI), gain:feed, and gain:net energy intake. Blood samples were collected prior to transport, following transport, and on days 2, 7, 14, 28, and 35 postweaning and transport to analyze cortisol, glucose, insulin, and nonesterified fatty acids. Behavior was assessed through video-recording on days 3, 5, 8, 11, and 13 postweaning and transport. In period 1, ADG was reduced (P = 0.04; 20.0 g/d) in IUHS vs. IUTN pigs. Pigs fed ND diets had reduced ADFI (P = 0.02; 9.3%) compared with C diet-fed pigs during period 1, which resulted in similar ADEI (P = 0.23; 1,115 ± 35 kcal/d). During transport, cortisol was decreased (P = 0.03; 25.8%) in IUHS vs. IUTN pigs. On day 2, glucose was decreased (P = 0.01; 13.8%) in IUHS vs. IUTN pigs. No in utero treatment-related behavior differences were observed but lying was reduced (P = 0.03; 6.5%) and standing was increased (P = 0.04; 14.1%) in ND vs. C pigs overall. In summary, IUHS reduced growth performance in pigs following weaning and transport, and providing an ND diet did not rescue the lost performance.
Evaluating Trends in Novel Psychoactive Substances Using a Sentinel Population of Electronic Dance Music Festival Attendees
Authors: Mohr Amanda L A , Fogarty Melissa F , Krotulski Alex J , Logan Barry K 
Published: August 2020

Abstract
Electronic dance music (EDM) festivals have become a popular venue for recreational drug use, including the use of traditional stimulants like 3,4-methylenendioxymethamphetamine (MDMA) and novel psychoactive substances (NPS). Using this cohort of people who use drugs recreationally, this study sought to collect biological specimens and self-reported drug use data from EDM festival attendees in the United States to monitor regional and temporal trends related to NPS use and turnover between 2014 and 2017. Oral fluid samples were collected at three United States EDM festival locations, including Miami, Florida (2014 to 2017); Tampa, Florida (2017) and Atlanta, Georgia (2017). Samples were screened by liquid chromatography–quadrupole time-of-flight mass spectrometry and confirmed by liquid chromatography–tandem mass spectrometry. Over the 4 years, 1,233 oral fluid samples were collected. With respect to self-reported drug use, 63% of respondents reported medicinal and/or recreational drug use within the last week. When comparing 4 years of data from Miami (2014 to 2017), NPS trends showed the disappearance of alpha-PVP after 2014 followed by a significant increase in ethylone positivity in 2015 and rapid decrease in 2016. Dibutylone was identified for the first time in Miami 2016, and N-ethyl pentylone was identified for the first time in Miami 2017. Additionally, 3,4-methylenendioxymethamphetamine positivity steadily increased from 2014 to 2017. A comparison across study sites (Miami, Tampa and Atlanta) and specific trends with respect to novel simulant use are described within. Using this opportunistic approach of monitoring drug trends, we have found that peak positivity of novel stimulants usually is within a year of their first detection. Understanding the dynamics of NPS drug markets will allow laboratories to plan for resource allocation and scope updates within a timely fashion to assist with the detection and confirmation of these emerging substances in samples submitted for forensic analysis.
Selective Linear Segmentation for Detecting Relevant Parameter Changes
Authors: Dufays Arnaud , Houndetoungan Elysee Aristide , Coën Alain 
Published: August 2020

AbstractChange-point (CP) processes are one flexible approach to model long time series. We propose a method to uncover which model parameters truly vary when a CP is detected. Given a set of breakpoints, we use a penalized likelihood approach to select the best set of parameters that changes over time and we prove that the penalty function leads to a consistent selection of the true model. Estimation is carried out via the deterministic annealing expectation-maximization algorithm. Our method accounts for model selection uncertainty and associates a probability to all the possible time-varying parameter specifications. Monte Carlo simulations highlight that the method works well for many time series models including heteroskedastic processes. For a sample of fourteen hedge fund (HF) strategies, using an asset-based style pricing model, we shed light on the promising ability of our method to detect the time-varying dynamics of risk exposures as well as to forecast HF returns.
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo
Authors: Weitzman Sarah A , Narasimhan Sneha , He Zhuohao , Changolkar Lakshmi , McBride Jennifer D , Zhang Bin , Schellenberg Gerard D , Trojanowski John Q , Lee Virginia M Y 
Published: August 2020

Abstract
One hallmark of neurodegenerative diseases is the intracellular accumulation of hyperphosphorylated tau protein, a neuronal microtubule-associated protein, into structures known as neurofibrillary tangles. Tauopathies are heterogeneous neurodegenerative diseases caused by the misfolding of the tau protein. It has been previously shown that the tau protein can spread from cell to cell in a prion-like manner. Tauopathies can be sporadic or familial, with the identification of pathogenic mutations in the microtubule-associated protein tau gene on chromosome 17 in the familial cases. Different frontotemporal dementia with parkinsonism-17 (FTDP-17) cases are associated with varying clinical presentations and types of neuropathology. We previously demonstrated that insoluble tau extracted from sporadic tauopathy human brains contain distinct tau strains, which underlie the heterogeneity of these diseases. Furthermore, these tau strains seeded tau aggregates that resemble human tau neuropathology in nontransgenic and 6hTau mice in vivo. Here, we show insoluble tau from human brains of FTDP-17 cases transmit different patterns of neuronal and glial tau pathology in vivo, similar to the sporadic tauopathies. This suggests that each of these tau mutations has unique properties that underlie the heterogeneity of FTDP-17 cases.
Contribution of plant traits to the explanation of temporal variations in carbon and water fluxes in semiarid grassland patches
Authors: Wang Mengyu , Lu Nan , Li Qinglin , Fang Weiwei , Fu Bojie 
Published: August 2020

AbstractAimsAccurate prediction of spatiotemporal variations in carbon and water fluxes of heterogeneous landscape is critical to comprehensively address the effects of climate change and vegetation dynamics on landscape and regional carbon and water cycling.MethodsA field study was conducted to characterize the seasonal variations in gas fluxes and explore their relationships with abiotic and biotic factors in a small grassland landscape. Daytime carbon and water fluxes including net ecosystem exchange, gross ecosystem productivity, ecosystem respiration and evapotranspiration (ET) were measured for three types of grassland patches over a growing season using the closed chamber method. The key plant trait variables were measured, based on which community weighted mean (CWM) and functional variance (FDvar) were calculated.Important FindingsThe results showed that the temporal variations in the carbon and water fluxes were regulated by meteorological, soil and community functional variables. Inclusion of the CWM and FDvar of plant trait measures greatly improved the degree of explanation of the predict models. Specific leaf area and leaf δ13C content (Lδ13C) were the most important trait variables in affecting the variations of the gas fluxes. CWMs indices had greater importance than FDvar indices in predicting the variation of the C fluxes but FDvar indices were more important for ET than C fluxes. Our findings demonstrated that mass ratio hypothesis and the complementary effects hypothesis are not mutually exclusive but have different relative importance for different ecosystem processes. Community functional traits played important roles in predicting the spatiotemporal variations of carbon and water fluxes in semiarid grassland.
Leaf turgor loss point at full hydration for 41 native and introduced tree and shrub species from Central Europe
Authors: Kunert Norbert , Tomaskova Ivana 
Published: August 2020

Abstract
The last years, Central European forests have suffered from drought as a direct consequence of climate change. All these forests have a long management history and it lies in the landowner’s responsibility to replant damaged forests. Hence, landowners and the government are searching currently for species suitable to replant in areas affected by tree die-offs. It is a matter of fact that good knowledge of drought resistance of species is a critical measure for the current replanting efforts. We determined a widely recognized trait for leaf drought tolerance (leaf water potential at turgor loss point at full hydration, πtlp) in 41 woody species native or introduced in Central Europe. The osmometric rapid assessment method was used to measure the leaf osmotic potential at full hydration (πosm) of sun-exposed leaves and converted to πtlp. Mean πtlp of the native species was −2.33 ± 0.33 MPa. The less negative πtlp was found in the introduced species Aesculus hypocastania and was at −1.70 ± 0.11 MPa. The most negative πtlp, and thus the potentially highest drought tolerance, were found in the introduced species Pseudotsuga menzesii and was at −3.02 ± 0.14 MPa. High or less negative πtlp is associated with lower drought tolerance, whereas low or more negative πtlp stands for higher resistance to drought stress. For example, the two native species Illex aquifolium and Alnus glustinosa are species naturally associated with moist habitats and are characterized by the least negative πtlp of −1.75 ± 0.02 and −1.76 ± 0.03 MPa, respectively.
Middle segment-preserving pancreatectomy for multifocal pancreatic ductal adenocarcinoma located in the head and tail of the pancreas: a case report
Authors: Nitta Nobuhito , Yamamoto Yusuke , Sugiura Teiichi , Okamura Yukiyasu , Ito Takaaki , Ashida Ryo , Ohgi Katsuhisa , Otsuka Shimpei , Sasaki Keiko , Uesaka Katsuhiko 
Published: August 2020

Abstract
A 77-year-old woman with a solitary existence was referred to our hospital for the treatment of pancreatic tumors. Computed tomography revealed an 18-mm mass in the pancreatic head that had invaded the right side of the superior mesenteric vein (SMV) and a 32-mm mass in the pancreatic tail. We performed middle segment-preserving pancreatectomy (MSPP) with SMV resection and reconstruction. The TNM classifications were T2, N1, M0, stage IIB in the pancreatic head, and T2, N0, M0, stage IB in the pancreatic tail, respectively. Postoperatively, the blood glucose was well controlled using only hypoglycemic drug, and insulin preparation was not necessary. No fatty diarrhea was found using a pancreatic enzyme supplement. After 9 months of follow-up, no recurrence was found. MSPP for pancreatic head and tail carcinomas seemed acceptable for both preserving the postoperative quality of life and ensuring curative resection especially in elderly patient with a solitary existence.
Extending Peer Support Across the Military Health System to Decrease Clinician Burnout
Authors: Keyser Erin A , Weir Larissa F , Valdez Michelle M , Aden James K , Matos Renée I 
Published: August 2020

Abstract

Introduction
Clinician burnout is widespread throughout medicine, affecting professionalism, communication, and increases the risk of medical errors, thus impacting safe quality patient care. Previous studies have shown Peer Support Programs (PSPs) promote workforce wellness by supporting clinicians during times of heightened stress and vulnerability. Although these programs have been implemented in large institutions, they have not been used in military hospitals, which have high staff turnover and added stressors of deployments.

Materials and Methods
In December 2018, 50 physicians received 5 hours of PSP training at a military hospital from a nationally recognized PSP expert, following the programmatic structure described by Shapiro and Galowitz (2016). Utilization of the program was tracked from December 2018 to December 2019, recording only classification of provider type, triggering event, and provider specialty to maintain confidentiality. Qualitative comments from recipients and supporters were saved anonymously for quality improvement purposes.

Results
In the first year of our PSP, 254 clinicians (102 [40.2%] residents/fellows, 91 [35.8%] staff physicians, 4 [1.6%] medical students, 35 [13.8%] nurses, 22 [8.7%] allied health) received 1:1 peer support. Primary specialties utilizing peer support included 135 (52.9%) medical, 59 (23.2%) surgical, 43 (16.9%) obstetric, and 18 (7.1%) pediatric. Patient death (25%), risk management notification (22%), medical error/complication (15%), and poor patient outcome (13%) were the most common events triggering peer support. Peer support was provided at 8 locations across the continental United States with universally positive comments from recipients.

Conclusions
Implementation of a PSP at our institution led to rapid utilization across multiple hospitals in the military health system, a model that could easily expand to deployed settings and remote locations. Access to peer support across the military health system could both mitigate the increased risks of military clinician burnout, and improve patient safety, healthcare worker resilience, and service member readiness.
Antifungal effect of anthraquinones againstCryptococcus neoformans: detection of synergism with amphotericin B
Authors: Brilhante Raimunda Sâmia Nogueira , dos Santos Araújo Géssica , Fonseca Xhaulla Maria Quariguasi Cunha , de Melo Guedes Glaucia Morgana , de Aguiar Lara , de Souza Collares Maia Castelo-Branco Débora , de Aguiar Cordeiro Rossana , Sidrim José Júlio Costa , Pereira Neto Waldemiro Aquino , Rocha Marcos Fábio Gadelha 
Published: August 2020

AbstractThe emergence of tolerant Cryptococcus neoformans strains to antifungals has been described. It has directed researchers to screen for new antimicrobial compounds. In this context, several plant-derived compounds, such as anthraquinones (aloe emodin, barbaloin, and chrysophanol), have been investigated for their antimicrobial properties. This study aimed to evaluate the in vitro effect of aloe emodin, barbaloin and chrysophanol on C. neoformans in vitro growth. In addition, the interaction between these anthraquinones and amphotericin B and itraconazole was evaluated. Initially, the minimum inhibitory concentrations (MIC) of these compounds were determined against 17 strains of C. neoformans by the broth microdilution method and then pharmacological interaction assays were performed with 15 strains by the checkerboard method. Aloe emodin, barbaloin, and chrysophanol showed minimum inhibitory concentrations of 236.82–473.65 μM (64–128 μg/mL), 153–306 μM (64–128 μg/ml) and ≥1007 μM (≥256 μg/ml), respectively. Furthermore, aloe emodin (11/15), barbaloin (13/15), and chrysophanol (12/15) showed pharmacological synergism (FICI &lt; 0.5) with amphotericin B at subinhibitory concentrations (MIC/4). The itraconazole-aloe emodin interaction was additive (1/15) (0.5 &lt; FICI &lt; 1.0). The itraconazole-barbaloin interaction were synergistic (2/15) and additive (5/15); whereas itraconazole-chrysophanol interactions were additive (2/15). Anthraquinones, especially aloe emodin and barbaloin, present in vitro antifungal activity against C. neoformans and potentiate the antifungal activity of amphotericin B.
warpfield population synthesis: the physics of (extra-)Galactic star formation and feedback-driven cloud structure and emission from sub-to-kpc scales
Authors: Pellegrini Eric W , Reissl Stefan , Rahner Daniel , Klessen Ralf S , Glover Simon C O , Pakmor Rüdiger , Herrera-Camus Rodrigo , Grand Robert J J 
Published: August 2020

ABSTRACT
We present a novel method to model galactic-scale star formation and emission of star clusters and a multiphase interstellar medium (ISM). We combine global parameters, including star formation rate and metallicity, with the 1D cloud evolution code warpfield to model the sources of feedback within a star-forming galaxy. Within individual star-forming regions, we include stellar evolution, stellar winds, radiation pressure, and supernovae, all coupled to the dynamical evolution of the 1D parental cloud in a highly non-linear fashion. Heating of the diffuse galactic gas and dust is calculated self-consistently with the age-, mass-, and density-dependent escape fractions of photons from these fully resolved local star-forming regions. We construct the interstellar radiation field, and we employ the multifrequency radiative transfer code polaris to produce synthetic emission maps for a one-to-one comparison with observations. We apply this to a cosmological simulation of a Milky-Way-like galaxy built-up in a high-resolution MHD simulation of cosmic structure formation. From this, we produce the multiscale/phase distribution of ISM density and temperature and present a synthesized all-sky H  α map. We use a multipole expansion to show that the resulting maps reproduce all observed statistical emission characteristics. Next, we predict [S iii] 9530 Å, a key emission line that will be observed in several large forthcoming surveys. It suffers less extinction than other lines and provides information about star formation in very dense environments that are otherwise observationally inaccessible optically. Finally, we explore the effects of differential extinction, and discuss the consequences for the interpretation of H α emission at different viewing angles by an extragalactic observer.