bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypes of Women with and Without Endometriosis and Relationship with Functional Pain Disability
Authors: Evans Subhadra , Mikocka-Walus Antonina , Olive Lisa , Seidman Laura C , Druitt Marilla , Payne Laura A 
Published: September 2020

AbstractObjectivePrimary dysmenorrhea and secondary dysmenorrhea due to endometriosis share overlapping symptoms and likely demonstrate aspects of central sensitization. The present study aimed to identify distinct phenotypes of women who have dysmenorrhea with and without endometriosis to shed light on the unique mechanisms contributing to the pathogenesis of each condition.MethodsAn online survey was used to investigate the relationship between ratings of menstrual pain severity, menstrual symptoms (abdominal cramps, abdominal discomfort, low back pain, headache, body aches, bloating, nausea, diarrhea, increased bowel movements), widespread pain, and functional pain disability in a community sample of 1,354 women (aged 18–50) with menstrual pain in Australia.ResultsCompared with women without endometriosis, those with endometriosis had statistically significant higher menstrual pain severity (P&lt;0.01), symptom severity and fatigue (all symptoms P&lt;0.001, although only cramps and bloating were clinically significant), widespread pain sites (P&lt;0.001), and functional pain disability (P&lt;0.001, although this difference was not clinically significant). When examining symptoms by pain severity, women with severe menstrual pain were more likely to experience symptoms than women with less severe pain, regardless of the presence of endometriosis. Similar predictors of functional pain disability emerged for women with and without endometriosis, such as body aches, nausea, fatigue, and widespread pain, respectively, suggesting the presence of central sensitization in both groups. Logistic regression revealed that after accounting for menstrual pain severity (odds ratio [OR], 1.61) and duration (OR, 1.04), symptoms of bloating (OR, 1.12), nausea (OR, 1.07), and widespread pain sites (OR, 1.06) significantly predicted the presence of endometriosis.ConclusionsThe findings suggest that phenotypes specific to endometriosis can be identified.
Shadow Banking and the Four Pillars of Traditional Financial Intermediation
Authors: Farhi Emmanuel , Tirole Jean 
Published: September 2020

Abstract
Traditional banking is built on four pillars: small and medium enterprise lending, insured deposit taking, access to lender of last resort (LOLR), and prudential supervision. This article unveils the logic of the quadrilogy by showing that it emerges naturally as an equilibrium outcome in a game between banks and the government. A key insight is that regulation and public insurance services (LOLR, deposit insurance) are complementary. The model also shows how prudential regulation must adjust to the emergence of shadow banking and rationalizes structural remedies to counter bogus liquidity hoarding and financial contagion: ring-fencing between regulated and shadow banking and the sharing of liquidity in centralized platforms.
Insomnia with objective short sleep duration is associated with cognitive impairment: a first look at cardiometabolic contributors to brain health
Authors: Fernandez-Mendoza Julio , He Fan , Puzino Kristina , Amatrudo Gregory , Calhoun Susan , Liao Duanping , Vgontzas Alexandros N , Bixler Edward 
Published: September 2020

Abstract

Study Objectives
Insomnia with objective short sleep duration has been previously associated with adverse cardiometabolic health outcomes as well as poorer cognitive performance in otherwise noncognitively impaired adults. However, studies demonstrating an increased prevalence of cognitive impairment (CI) in this insomnia phenotype are lacking.

Methods
We analyzed data from Penn State Adult Cohort (N = 1,524; 48.9 ± 13.4 years; 53.4% women). Self-reported sleep difficulty was defined as normal sleep (n = 899), poor sleep (n = 453), and chronic insomnia (n = 172). Objective short sleep duration was defined as less than 6-h of sleep, based on in-lab, 8-h polysomnography. CI (n = 155) and possible vascular cognitive impairment (pVCI, n = 122) were ascertained using a comprehensive neuropsychological battery. Analyses adjusted for age, sex, race, education, body mass index, apnea/hypopnea index, smoking, alcohol, psychoactive medication, and mental and physical health problems.

Results
Participants who reported poor sleep or chronic insomnia and slept objectively less than 6 hours were associated with a 2-fold increased odds of CI (OR = 2.06, 95% confidence limits [CL] = 1.15–3.66 and OR = 2.18, 95% CL = 1.07–4.47, respectively) and of pVCI (OR = 1.94, 95% CL = 1.01–3.75 and OR = 2.33, 95% CL = 1.07–5.06, respectively). Participants who reported poor sleep or chronic insomnia and slept objectively more than 6 hours were not associated with increased odds of either CI (OR = 0.72, 95% CL = 0.30–1.76 and OR = 0.75, 95% CL = 0.21–2.71, respectively) or pVCI (OR = 1.08, 95% CL = 0.42–2.74 and OR = 0.76, 95% CL = 0.16–3.57, respectively).

Conclusions
Insomnia with objective short sleep duration is associated with an increased prevalence of CI, particularly as it relates to cardiometabolic health (i.e. pVCI). These data further support that this insomnia phenotype may be a more biologically severe form of the disorder associated with cardiovascular, cerebrovascular, and neurocognitive morbidity.
Azithromycin Associated with Increased Risk of Death in Outpatients
Authors: Rosenberg Karen 
Published: September 2020

According to this study:

Outpatients who used azithromycin had an approximately twofold increased risk of cardiovascular death and noncardiovascular death in the five days after the prescription was dispensed, compared with patients who used amoxicillin.No increased risk of death was found in the six to 10 days after prescription dispensing.
Meeting the Rehabilitation and Support Needs of Patients With Breast Cancer During COVID-19: Opening New Frontiers in Models of Care
Authors: Binkley Jill , Mark Mallory , Finley Janae , Brazelton Allison , Pink Marilyn 
Published: September 2020

Background:
COVID-19 presents a significant challenge to providing specialized rehabilitation and exercise for patients with breast cancer.

Objective:
The purpose of this report is to describe the implementation of telerehabilitation for one-on-one patient care and interactive, live, Web-based formats for group patient education, exercise, and support programs during the COVID-19 pandemic.

Design:
This report describes the concept, materials, and methods used in a community-based clinical setting to serve patients' needs during COVID-19.

Results:
Telerehabilitation and interactive Web-based strategies may be useful in meeting the physical and emotional needs of patients with breast cancer. Brief patient cases summarize the process of one-on-one telerehabilitation implementation and provide patient and family perspectives. Challenges and benefits of telerehabilitation are described. Interactive Web-based strategies substantially increased the numbers of patients reached with survivorship education and support groups during the first 2 months of COVID-19.

Limitations:
This report is descriptive and does not include group outcomes. Further research is needed to compare outcomes of telerehabilitation versus in-person delivery of breast cancer rehabilitation care.

Conclusion:
Telerehabilitation and interactive Web-based education formats provide an alternative to in-person breast cancer rehabilitation care during COVID-19 and have potential application for improving delivery of care to underserved populations and in other types of cancer.
Use of Reflectance Confocal Microscopy to Predict Treatment Efficacy in Café Au Lait Macules
Authors: Peng Hao , Shen Lingyue , Yu Wenxin , Lin Xiaoxi , Sun Kai , Zhou Guoyu 
Published: September 2020

BACKGROUND
Multiple lasers have been used for the treatment of café au lait macules (CALMs) with various results. Objective tools to predict therapeutic efficacy of CALMs treatment is lacking.

OBJECTIVE
To determine whether reflectance confocal microscopy (RCM) characteristics correlate with CALMs response to laser treatment.

MATERIALS AND METHODS
All CAMLs underwent RCM examination of length and density of dermal papillae followed by 3 sessions of Q-switched alexandrite laser (QSAL). A visual analog scale was used to assess clinical treatment efficacy.

RESULTS
Forty-three patients were included, 22 had CALMs with irregular borders and 21 with smooth borders. Café au lait macules with irregular border had shorter rete pegs and less papillae (p < .05) on RCM compared with smooth border CAMLs and responded better to QSAL treatment (2.32 vs 1.10).

CONCLUSION
Reflectance confocal microscopy measurement of length and density of papillae were inversely correlated with treatment response. Reflectance confocal microscopy may be a useful tool to predict CALMs response to laser treatment.
Effectiveness and safety of light vegetarian diet and Qingjiang Tiaochang Recipe for functional constipation
Authors: Liu Xinyuan , Liu Yu , Chen Jialiang , Wang Huijing , Wang Qianqian , Niu Zuohu , Yun Zhangjun , Ma Bingzhi , Yao Shunkun 
Published: September 2020

AbstractIntroduction:Functional constipation is a chronic disease that is common in children and adults around the world. The treatments for functional constipation include diet and lifestyle interventions, medications, and surgery. The diet pattern plays an important role in the occurrence of constipation. We found in clinical practice that simple application of drugs cannot achieve long-term relief of constipation, and a large number of patients are not satisfied with the existing treatment. We have concluded that Qingjiang Tiaochang Recipe (QJTCR) and light vegetarian diet (LVD) can effectively improve constipation. However, there is no enough evidence for the description of the effect. This protocol aims at exploratorily investigating effectiveness and safety of LVD and QJTCR following a rigorous clinical trial.Methods and analysis:We will recruit 90 patients to participate in this prospective, placebo-controlled, randomized trial, and exploratory study at the China-Japan Friendship Hospital, including traditional Chinese medicine group, placebo + diet group, traditional Chinese medicine + diet group. Patients in the diet intervention group must strictly abide by LVD, and the study will continue for 28 days. During the intervention period, we need to record a designed diary to assess diet quality and defecation. The primary outcomes for this clinical study were weekly complete spontaneous bowel movements. The secondary outcomes were constipation-related symptom rating scale, traditional Chinese medicine syndrome scale, and 48-hour gastrointestinal transit time, high-resolution anorectal manometry, Bristol stool score, constipation quality of life assessment scale, constipation symptoms self-assessment scale, short-chain fatty acids in feces. In addition, the study will determine the safety of the intervention.
Effect of traditional Chinese medicine injections on severe pneumonia
Authors: Luo Wei , Liu Ya , Zhang Qiang , Zhong Huifang , Deng Jia 
Published: September 2020

Abstract

Background:
Traditional Chinese medicine injections (TCMJ) used in the treatment of severe pneumonia have been widely implemented in clinical practice, but their overall efficacy and safety remain unclear. This paper aims to evaluate the efficacy and safety of TCMJ in the treatment of severe pneumonia.

Methods:
PubMed, EMbase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, WanFang, and the Chongqing VIP Chinese Science and Technology Periodical Database were all searched for randomized controlled trials focusing on the administration of TCMJ for severe pneumonia. Two researchers independently screened titles, abstracts, full texts, and extracted relevant data. The RevMan 5.3 software (The Cochrane Collaboration, Software Update, Oxford, UK) and Stata 14 software (STATA Corporation, College Station, TX) were used for statistical analysis.

Results:
This study summarizes the related randomized controlled trials to assess the effect and safety of TCMJ in the treatment of severe pneumonia.

Conclusion:
This article provides theoretical support for the clinical application of TCMJ in the treatment of severe pneumonia.

PROSPERO Registration number:
CRD42020185072
Arthroscopic capsular release for the treatment of post-stroke frozen shoulder
Authors: Zong Long-ze , Ma Li , Liu Ying-ying 
Published: September 2020

Abstract

Background:
This study will assess the efficacy and safety of arthroscopic capsular release (ACR) for the treatment of post-stroke frozen shoulder (PSFS).

Methods:
We will carry out a systematic study of randomized controlled trials that assess the efficacy and safety of ACR for PSFS. We will search all potential records for any eligible trials from selected electronic databases (MEDLINE, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, WANGFANG, and China National Knowledge Infrastructure) and grey literature sources from inception to the present. Two authors will independently perform study selection, data extraction, and study quality assessment. Any disagreement will be solved by a third author via consultation. Statistical analysis will be carried out by RevMan 5.3 software.

Results:
This study will comprehensively summarize current eligible studies to systematically assess the efficacy and safety of ACR for PSFS.

Conclusion:
This study will provide evidence to determine whether ACR is an effective management for patients with PSFS.
Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis
Authors: Gao Guangyu , Shi Xinya , Yao Zhen , Shen Jiaofeng , Shen Liqin 
Published: September 2020

Abstract

Background:
Lymph node metastasis is a significant problem in breast cancer, and its underlying molecular mechanism is still unclear. The purpose of this study is to research the molecular mechanism and to explore the key RNAs and pathways that mediate lymph node metastasis in breast cancer.

Methods:
GSE100453 and GSE38167 were downloaded from the Gene Expression Omnibus (GEO) database and 569 breast cancer statistics were also downloaded from the TCGA database. Differentially expressed miRNAs were calculated by using R software and GEO2R. Gene ontology and Enriched pathway analysis of target mRNAs were analyzed by using the Database for Database of Annotation Visualization and Integrated Discovery (DAVID) and R software. The protein–protein interaction (PPI) network was performed according to Metascape, String, and Cytoscape software.

Results:
In total, 6 differentially expressed miRNAs were selected, and 499 mRNAs were identified after filtering. The research of the Kyoto Encyclopedia of Genes and Genomes (KEGG) demonstrated that mRNAs enriched in certain tumor pathways. Also, certain hub mRNAs were highlighted after constructed and analyzed the PPI network. A total of 3 out of 6 miRNAs had a significant relationship with the overall survival (P < .05) and showed a good ability of risk prediction model of over survival.

Conclusions:
By utilizing bioinformatics analyses, differently expressed miRNAs were identified and constructed a complete gene network. Several potential mechanisms and therapeutic and prognostic targets of lymph node metastasis were also demonstrated in breast cancer.
Germinal ovarian tumors in reproductive age women
Authors: Dellino Miriam , Silvestris Erica , Loizzi Vera , Paradiso Angelo , Loiacono Rosalia , Minoia Carla , Daniele Antonella , Cormio Gennaro 
Published: September 2020

Abstract
MOGCTs (malignant ovarian germ cell tumors) are rare tumors that mainly affect patients of reproductive age. The aim of this study was to evaluate the fertility and survival outcomes in young women with MOCGTs treated with fertility-sparing surgery (FSS).
From 2000 to 2018, data from 28 patients of reproductive age with a diagnosis of MOGCT at the University of Bari were collected. Most received FSS, and in patients treated conservatively, the reproductive outcome and survival were investigated. Data of patient demographics, clinical presentation, oncology marker dosage, staging, type of surgery, histological examination, survival, and reproductive outcome were collected from hospital and office charts. All informed consent was obtained from all patients. The median age was 24 (range: 9–45 years). The majority of the patients had stage IIIC. Twenty-four woman received FSS consisting of unilateral ovariectomy and omentectomy, whereas only 4 women, based on their stage (IIIC), received a radical surgery (hysterectomy with bilateral adnexectomy, lymphadenectomy, and omentectomy). Our study shows that FSS in MOGCTs can produce good results both on reproductive outcomes and on survival. Indeed, in our group, there was only 1 case of exitus as result of recurrence. Furthermore, patients after FSS maintained normal ovarian function and 5 of 5 women who tried to get pregnant succeeded spontaneously. The median follow-up was 90 months (range 3–159).
Conservative surgery for MOGCTs should be considered for women of reproductive age who wish to preserve fertility.
Identification of osteoporosis markers through bioinformatic functional analysis of serum proteome
Authors: Lv Mengying , Cui Chuanlong , Chen Peng , Li Ziqi 
Published: September 2020

Abstract
Osteoporosis is a severe chronic skeletal disorder that increases the risks of disability and mortality; however, the mechanism of this disease and the protein markers for prognosis of osteoporosis have not been well characterized. This study aims to characterize the imbalanced serum proteostasis, the disturbed pathways, and potential serum markers in osteoporosis by using a set of bioinformatic analyses. In the present study, the large-scale proteomics datasets (PXD006464) were adopted from the Proteome Xchange database and processed with MaxQuant. The differentially expressed serum proteins were identified. The biological process and molecular function were analyzed. The protein–protein interactions and subnetwork modules were constructed. The signaling pathways were enriched. We identified 209 upregulated and 230 downregulated serum proteins. The bioinformatic analyses revealed a highly overlapped functional protein classification and the gene ontology terms between the upregulated and downregulated protein groups. Protein–protein interactions and pathway analyses showed a high enrichment in protein synthesis, inflammation, and immune response in the upregulated proteins, and cell adhesion and cytoskeleton regulation in the downregulated proteins. Our findings greatly expand the current view of the roles of serum proteins in osteoporosis and shed light on the understanding of its underlying mechanisms and the discovery of serum proteins as potential markers for the prognosis of osteoporosis.
Effects of blood flow on the antibacterial efficacy of chlorhexidine and silver sulfadiazine coated central venous catheter
Authors: Cui Yong Huan , Choi Yoon Ji , Kim Eung Hwi , Yu Joon Ho , Seong Hyun Young , Choi Sung-uk , Yoon Seung Zhoo , Huh Hyub 
Published: September 2020

Abstract

Background:
Chlorhexidine and silver sulfadiazine coated central venous catheters (CSS-CVC) may cause loss of antimicrobial efficacy due to friction between the CVC surface and sheer stress caused by the blood flow. Therefore, the aim of this study was to investigate the antibacterial efficacy of CSS-CVC at various flow rates using a bloodstream model.

Methods:
Each CVC was subjected to various flow rates (0.5, 1, 2, and 4 L/min) and wear-out times (0, 24, 48, 72, 96, and 120 hours), and the optical density (OD) 600 after a Staphylococcus aureus incubation test was used to determine the antibacterial effect of CSS-CVC.

Results:
In the 0.5 L/min group, there was no significant change in the OD600 value up to 120 hours compared with the baseline OD600 value for CSS-CVC (P > .467). However, the OD600 values of CSS-CVC in the 1 L/min (P < .001) and 2 L/min (P < .001) groups were significantly reduced up to 72 hours, while that in the 4 L/min (p < 0.001) group decreased rapidly up to 48 hours.

Conclusion:
This study suggests that there is a doubt whether sufficient antibacterial function can be maintained with prolonged duration of catheter placement.
Efficacy and safety of total glucosides of paeony for rheumatoid arthritis
Authors: Tang Ce , Ye Lianghong , Hu Zhipeng , Wang Wenxiang , Kuang Tingting , Fan Gang , Zhang Yi , Liu XiuHua , Yang Maoyi 
Published: September 2020

Abstract

Background:
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by erosion of joints and surrounding tissues. RA not only causes the decline of patients’ physical function and quality of life, but also brings huge economic burden to patients’ families and society. Total glucosides of paeony (TGP) is commonly used in treating RA in China. At present, there are many clinical reports about this medicine, but these reports have their own flaws. Therefore, there is an urgent need for systematic review and meta-analysis of the existing clinical evidence.

Methods and analysis:
Literature search will be carried out in 6 databases, and the literatures will be screened according to the inclusion and exclusion criteria. The clinical effective rate will be taken as primary outcome. Serum rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, Western Ontario and McMaster before and after treatment and adverse effects will be secondary outcomes. The heterogeneity of the study will be examined by χ
2 and I
2 test. To identify the source of heterogeneity, subgroup analysis will be carried out. The sensitivity test will be conducted investigate the stability of results. Funnel plot and Egger test will be used to evaluate publication bias. Finally, the quality of evidence will be summarized.

Results:
The results will be published in peer-reviewed journals.

Conclusions:
This study will systematically evaluate the efficacy of TGP in the treatment of RA. The results of this study can better guide clinical practice.

OSF registration number:
DOI 10.17605/OSF.IO/85QVF.
Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer
Authors: Nakano Shintaro , Komatsu Yoshito , Kawamoto Yasuyuki , Saito Rika , Ito Ken , Nakatsumi Hiroshi , Yuki Satoshi , Sakamoto Naoya 
Published: September 2020

Abstract
It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP.
We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hospital.
Ninety-nine patients were eligible for the study. Thirty-seven used antibiotics (U) and 62 did not use antibiotics (NU) during GnP therapy. In the U group, 15 patients used β-lactam antibiotics, 21 used new quinolones, and 1 used carbapenem. The median progression-free survival was 5.8 and 2.7 months (hazards ratio [HR] .602, 95% confidence interval [CI] .391–.928, P = .022) and the median overall survival was 11.0 and 8.4 months (HR .768, 95% CI .491–1.202, P = .248) in the U and not use antibiotics groups, respectively. Antibiotic use (HR .489, 95% CI .287–.832, P = .008) and locally advanced pancreatic cancer (HR 1.808, 95% CI 1.051–3.112, P = .032) were independent prognostic factors for progression-free survival.
Antibiotic use was associated with a higher efficacy of GnP, and therefore, it may be employed as a novel treatment strategy.