bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Epigenetic Pacemaker: modeling epigenetic states under an evolutionary framework
Authors: Farrell Colin , Snir Sagi , Pellegrini Matteo 
Published: June 2020

Abstract

Summary
Epigenetic rates of change, much as evolutionary mutation rate along a lineage, vary during lifetime. Accurate estimation of the epigenetic state has vast medical and biological implications. To account for these non-linear epigenetic changes with age, we recently developed a formalism inspired by the Pacemaker model of evolution that accounts for varying rates of mutations with time. Here, we present a python implementation of the Epigenetic Pacemaker (EPM), a conditional expectation maximization algorithm that estimates epigenetic landscapes and the state of individuals and may be used to study non-linear epigenetic aging.

Availability and Implementation
The EPM is available at https://pypi.org/project/EpigeneticPacemaker/ under the MIT license. The EPM is compatible with python version 3.6 and above.
Sleep spindles are resilient to extensive white matter deterioration
Authors: Sanchez Erlan , Arbour Caroline , El-Khatib Héjar , Marcotte Karine , Blais Hélène , Baril Andrée-Ann , Bedetti Christophe , Descoteaux Maxime , Lina Jean-Marc , Gilbert Danielle , Carrier Julie , Gosselin Nadia 
Published: June 2020

Abstract
Sleep spindles are an essential part of non-rapid eye movement sleep, notably involved in sleep consolidation, cognition, learning and memory. These oscillatory waves depend on an interaction loop between the thalamus and the cortex, which relies on a structural backbone of thalamo-cortical white matter tracts. It is still largely unknown if the brain can properly produce sleep spindles when it underwent extensive white matter deterioration in these tracts, and we hypothesized that it would affect sleep spindle generation and morphology. We tested this hypothesis with chronic moderate to severe traumatic brain injury (n = 23; 30.5 ± 11.1 years old; 17 m/6f), a unique human model of extensive white matter deterioration, and a healthy control group (n = 27; 30.3 ± 13.4 years old; 21m/6f). Sleep spindles were analysed on a full night of polysomnography over the frontal, central and parietal brain regions, and we measured their density, morphology and sigma-band power. White matter deterioration was quantified using diffusion-weighted MRI, with which we performed both whole-brain voxel-wise analysis (Tract-Based Spatial Statistics) and probabilistic tractography (with High Angular Resolution Diffusion Imaging) to target the thalamo-cortical tracts. Group differences were assessed for all variables and correlations were performed separately in each group, corrected for age and multiple comparisons. Surprisingly, although extensive white matter damage across the brain including all thalamo-cortical tracts was evident in the brain-injured group, sleep spindles remained completely undisrupted when compared to a healthy control group. In addition, almost all sleep spindle characteristics were not associated with the degree of white matter deterioration in the brain-injured group, except that more white matter deterioration correlated with lower spindle frequency over the frontal regions. This study highlights the resilience of sleep spindles to the deterioration of all white matter tracts critical to their existence, as they conserve normal density during non-rapid eye movement sleep with mostly unaltered morphology. We show that even with such a severe traumatic event, the brain has the ability to adapt or to withstand alterations in order to conserve normal sleep spindles.
The Evidence-Based Sexual Abuse Prevention Program: Strong With Sam
Authors: Urbann Katharina , Bienstein Pia , Kaul Thomas 
Published: June 2020

AbstractThe present study was initiated to design and evaluate a sexual abuse prevention program for deaf and hard of hearing (DHH) children. This evidence-based prevention program is the first of its kind for DHH children. A total of 92 DHH children aged 8–12 years participated in the program “STARK mit SAM” (Strong with Sam, SmS), a program conducted in primary schools for DHH children in Germany. The program evaluation consisted of a pretest−posttest design. As per class, the subjects were assigned to either the experimental or the wait list control group. Participants from both groups were pretested for their knowledge about content related to the prevention of sexual abuse. The experimental group received the prevention program and both groups were posttested to examine the effects of the program. Additionally, the experimental group was tested again 6 months after the program. DHH children who participated in the SmS program showed a significant knowledge gain and a nonsignificant change in their anxiety. No significant factor affecting the children’s significant knowledge gain was found. SmS is an effective sexual abuse prevention program for DHH children, which can be offered without incurring anxiety in the children.
External validation of the N descriptor in the proposed tumour–node–metastasis subclassification for lung cancer: the crucial role of histological type, number of resected nodes and adjuvant therapy
Authors: Chiappetta Marco , Lococo Filippo , Leuzzi Giovanni , Sperduti Isabella , Petracca-Ciavarella Leonardo , Bria Emilio , Mucilli Felice , Filosso Pier Luigi , Ratto Giovanni Battista , Spaggiari Lorenzo , Facciolo Francesco , Margaritora Stefano 
Published: June 2020

Abstract

OBJECTIVES

Overlapping survival curves for N1b (multiple N1 stations), N2a2 (single N2 station + N1 involvement) and N2a1 (skip N2 metastasis) limit the current tumour–node–metastasis (TNM) node (N) subclassification for node involvement. We validated externally the proposed subclassification.

METHODS
Clinical records from a multicentric database comprising 1036 patients with pulmonary adenocarcinoma (ADC) or squamous cell carcinoma with N1/N2 involvement who underwent, from January 2002 to December 2014, complete lung resections were retrospectively reviewed. Patients were categorized according to the 8th TNM N subclassification proposal. Histological type, number of resected nodes (#RN) and adjuvant therapy (ADJ) were considered limiting factors.

RESULTS
No difference in the 5-year overall survival (-OS) was noted between N1b and N2a1 (49.6% vs 44.8%, P = 0.72); instead, the 5-year-OS was significantly improved in patients with squamous cell carcinoma (63% in N1b vs 30.7% in N2a1, P = 0.04). In patients with ADC, the 5-year-OS was better in those with N2a1 than with N1b (50.6% vs 37.5%, P = 0.09). When we compared N1b with N2a2, the 5-year-OS was statistically significant (49.6% vs 32.8%, P = 0.02); considering only patients with squamous cell carcinoma (63% vs 25.8%, P = 0.003), #RN &gt;10 (63.2% vs 35.3%, P = 0.05) and without ADJ (56.4% vs 24.5%, P = 0.02), the 5-year-OS was significantly different. Differences were not significant for ADC, #RN &lt;10 and ADJ. Finally, the 5-year-OS was statistically significant when we compared N2a1 with N2a2 of the total cohort (44.8% vs 32.8%, P = 0.04), in ADC (5-year-OS 50.6% vs 36.5%, P = 0.04) and #RN &gt;10 (5-year-OS 49.8% vs 32.1%, P = 0.03) without ADJ.

CONCLUSIONS
Histological type, ADJ and #RN are relevant prognostic factors in N + non-small-cell lung cancer. Considering these results, we may better interpret the prognosis prediction limits of the proposed 8th TNM subclassification for the N descriptor.
Prevention and treatment of pulmonary congestion in patients undergoing venoarterial extracorporeal membrane oxygenation for cardiogenic shock
Authors: Lüsebrink Enzo , Orban Mathias , Kupka Danny , Scherer Clemens , Hagl Christian , Zimmer Sebastian , Luedike Peter , Thiele Holger , Westermann Dirk , Massberg Steffen , Schäfer Andreas , Orban Martin 
Published: June 2020

AbstractCardiogenic shock is still a major driver of mortality on intensive care units and complicates ∼10% of acute coronary syndromes with contemporary mortality rates up to 50%. In the meantime, percutaneous circulatory support devices, in particular venoarterial extracorporeal membrane oxygenation (VA-ECMO), have emerged as an established salvage intervention for patients in cardiogenic shock. Venoarterial extracorporeal membrane oxygenation provides temporary circulatory support until other treatments are effective and enables recovery or serves as a bridge to ventricular assist devices, heart transplantation, or decision-making. In this critical care perspective, we provide a concise overview of VA-ECMO utilization in cardiogenic shock, considering rationale, critical care management, as well as weaning aspects. We supplement previous literature by focusing on therapeutic issues related to the vicious circle of retrograde aortic VA-ECMO flow, increased left ventricular (LV) afterload, insufficient LV unloading, and severe pulmonary congestion limiting prognosis in a relevant proportion of patients receiving VA-ECMO treatment. We will outline different modifications in percutaneous mechanical circulatory support to meet this challenge. Besides a strategy of running ECMO at lowest possible flow rates, novel therapeutic options including the combination of VA-ECMO with percutaneous microaxial pumps or implementation of a venoarteriovenous-ECMO configuration based on an additional venous cannula supplying towards pulmonary circulation are most promising among LV unloading and venting strategies. The latter may even combine the advantages of venovenous and venoarterial ECMO therapy, providing potent respiratory and circulatory support at the same time. However, whether VA-ECMO can reduce mortality has to be evaluated in the urgently needed, ongoing prospective randomized studies EURO-SHOCK (NCT03813134), ANCHOR (NCT04184635), and ECLS-SHOCK (NCT03637205). These studies will provide the opportunity to investigate indication, mode, and effect of LV unloading in dedicated sub-analyses. In future, the Heart Teams should aim at conducting a dedicated randomized trial comparing VA-ECMO support with vs. without LV unloading strategies in patients with cardiogenic shock.
Characterization and bioremediation potential of nickel-resistant endophytic bacteria isolated from the wetland plant Tamarix chinensis
Authors: Chen Jun , Li Na , Han Sheng , Sun Yuankai , Wang Lili , Qu Zhili , Dai Meixue , Zhao Guoyan 
Published: June 2020

Abstract
Wetlands have been proposed as a sink for pollutants such as heavy metals. Wetland plants play a significant role in the phytoremediation of heavy metals. Here, we isolated and characterized three novel nickel (Ni)-resistant endophytic bacteria (NiEB) from the wetland plant Tamarix chinensis. The NiEB were identified as Stenotrophomonas sp. S20, Pseudomonas sp. P21 and Sphingobium sp. S42. All isolates tolerated 50 mg L−1 Ni, with isolates S20 and P21 being more tolerant to Ni at up to 400 mg L−1. Moreover, isolate S42 removed 33.7% of nickel sulfate from the water by forming white precipitates. The three isolates exhibited different plant growth-promoting (PGP) traits related to the production of indole acetic acid (IAA), siderophores and 1-aminocyclopropane-1-carboxylate (ACC) deaminase. Phytotoxicity studies revealed that the growth of the wetland plants in a high Ni concentration (200 mg L−1) recovered after co-incubation with isolate S42. Overall, this study presents the first report of NiEB isolation from wetland plants and provides novel insights into the diverse functions of endophytic bacteria in a plant host with the potential to improve Ni phytoremediation.
The Cultural History of Capitalism in France (With a Chicago touch)
Authors: Sewell William H 
Published: June 2020

Abstract
This is a commentary on articles by Oliver Cussen, Tyson Leuchter, Elizabeth Heath and Thomas Dodman, all of whom were University of Chicago PhD students in the 2000s or the 2010s. The articles partake of the currently rising general interest in the history of capitalism, but all examine capitalism less as an economic system than as a mode of life that generates and must be understood through cultural forms. I argue that all four of these contributions can be interpreted as either arguing directly or implying that behind the overt activities and rhythms of capitalist socio-cultural life one can find deeper and more abstract capitalist processes that usually escape the notice of but help to form the consciousness of the social actors.
Bioentity2vec: Attribute- and behavior-driven representation for predicting multi-type relationships between bioentities
Authors: Guo Zhen-Hao , You Zhu-Hong , Wang Yan-Bin , Huang De-Shuang , Yi Hai-Cheng , Chen Zhan-Heng 
Published: June 2020

Abstract

Background
The explosive growth of genomic, chemical, and pathological data provides new opportunities and challenges for humans to thoroughly understand life activities in cells. However, there exist few computational models that aggregate various bioentities to comprehensively reveal the physical and functional landscape of biological systems.

Results
We constructed a molecular association network, which contains 18 edges (relationships) between 8 nodes (bioentities). Based on this, we propose Bioentity2vec, a new method for representing bioentities, which integrates information about the attributes and behaviors of a bioentity. Applying the random forest classifier, we achieved promising performance on 18 relationships, with an area under the curve of 0.9608 and an area under the precision-recall curve of 0.9572.

Conclusions
Our study shows that constructing a network with rich topological and biological information is important for systematic understanding of the biological landscape at the molecular level. Our results show that Bioentity2vec can effectively represent biological entities and provides easily distinguishable information about classification tasks. Our method is also able to simultaneously predict relationships between single types and multiple types, which will accelerate progress in biological experimental research and industrial product development.
Interferon-β-1a Inhibition of Severe Acute Respiratory Syndrome–Coronavirus 2 In Vitro When Administered After Virus Infection
Authors: Clementi Nicola , Ferrarese Roberto , Criscuolo Elena , Diotti Roberta Antonia , Castelli Matteo , Scagnolari Carolina , Burioni Roberto , Antonelli Guido , Clementi Massimo , Mancini Nicasio 
Published: June 2020

Abstract
The ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2). Under this scenario, interferon (IFN) β-1a, whose antiviral potential is already known, and which is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. In this report, we demonstrate that IFN-β-1a was highly effective in inhibiting in vitro SARS-CoV-2 replication at clinically achievable concentration when administered after virus infection.
Nepantla Environmentalism: Challenging Dominant Frameworks for Green Religion
Authors: Baugh Amanda J 
Published: June 2020

AbstractScholarship on religious environmentalism and green religion in the United States has privileged the actions of progressive white activists who view nature through an Enlightenment framework. In response to a call in the 2015 JAAR’s roundtable on climate destabilization and religion to engage in discourse about “the myriad causes and myriad possible solutions to our environmental crisis,” this article examines religious environmentalism from a nondominant perspective. Based on ethnographic research among Latinx churchgoing Catholics in Los Angeles, I have identified a widespread ethic of living lightly on the earth, which I call nepantla environmentalism. It is grounded in an immanent, relational worldview in which God is present in the material and the human-nature boundary is porous. A focus on nepantla environmentalism calls attention to the raced and classed biases embedded in dominant understandings of green religion in the United States. It demonstrates that there are different ways of being a religious environmentalist.
Stimulant Abuse in Burn Patients Is Associated With an Increased Use of Hospital Resources
Authors: Hulsebos Ian F , Pham Christopher H , Collier Zachary J , Fang Mike , Vrouwe Sebastian Q , Sugiyama Akihiro , Yenikomshian Haig A , Garner Warren L , Gillenwater Justin 
Published: June 2020

Abstract
Stimulant (cocaine, methamphetamine, and amphetamine) abuse compromises the peripheral vasculature through endothelial injury. In combination with the physiologic derangements seen in burn injuries, patients abusing stimulants may have additional impairments in wound healing. A retrospective review from July 1, 2015 to July 1, 2018 was performed at an American Burn Association-verified burn center. Patients with positive urine toxicology results for stimulants (ST(+)), and those without (ST(−)), who sustained burn injuries were identified and matched by age and TBSA. The primary outcome was mortality, and secondary outcomes included total length of stay (LOS), and need-for-surgery (grafting). In total, 130 patients ST(+) and 133 ST(−) patients were identified. There were no significant differences in age (40.9 ± 13.5 vs 39.2 ± 23.7 years, P = 0.46), Inhalation Injury (12.3 vs 9.0%, P = 0.39), or nutritional status (prealbumin: 17.3 ± 6.1 vs 17.1 ± 12.7 mg/dl, P = 0.66; albumin: 3.5 ± 0.6 vs 3.6 ± 0.7 g/dl, P = 0.45). There were no differences in mortality (6.1 vs 4.5%, P = 0.55), intensive care unit LOS (9.3 ± 16.5 vs 10.2 ± 20.9 days, P = 0.81), wound infections (15.4 vs 23.9%, P = 0.07), or wound conversion (6.9 vs 3.0%, P = 0.14). ST(+) patients had a significantly longer LOS (15.0 ± 16.9 vs 10.7 ± 17.3 days, P = 0.04), greater tobacco use (56.9 vs 18.0%, P = 0.00001), and greater need for grafting (54.6 vs 33.1%, P = 0.0004). ST(+) patients require more hospital resources—surgical operations and hospital days—than ST(−) patients. The increased need for surgical intervention may partially explain the increase in hospital days, in addition to the observation that ST(+) patients had more complex disposition issues than ST(−) patients.
The Influence of Disease Cues on Preference for Typical versus Atypical Products
Authors: Huang Yunhui , Sengupta Jaideep 
Published: June 2020

Abstract
This article examines how exposure to disease-related cues influences consumers’ preference for typical (vs. atypical) product options. Merging insights from evolutionary psychology with research on preference for typicality in consumer products, we predict that disease salience decreases relative preference for typical versus atypical options, because typical products are implicitly associated with many people, misaligning them with the people-avoidance motive triggered by disease cues. We further build on this conceptualization to identify situations in which this preference shift might be eliminated. Specifically, we argue that the focal effect will not manifest when the disease in question is explicitly described to be noncontagious, or when an anti-infection intervention is introduced, or when the decision context involves minimum infection. Results from six studies provide support for our predictions, advancing basic knowledge on the evolutionary strategies guiding disease avoidance, while also documenting how such strategies can affect consumer preferences.
Choosing Ethnicity: The Interplay Between Individual and Social Motives
Authors: Jia Ruixue , Persson Torsten 
Published: June 2020

Abstract
This paper studies how material incentives and social norms shape ethnic identity choices in China. Provincial policies give material benefits to minorities, which consequently affect the ethnicity choices for children in ethnically mixed marriages. We formalize the ethnic identity choice in a simple framework, which highlights the interaction of (i) material benefits stemming from ethnic policies, (ii) identity costs associated with breaking the norm of following the father’s ethnicity, and (iii) social reputations altering the importance of identity costs. Consistent with the model, we find that ethnic policies increase the propensity to break the prevailing norm for mixed families with minority mothers. Moreover, the impact of ethnic policies is larger in localities where more such families follow the norm. More broadly, our study shows (1) how government policies can shape identity choices and (2) how one can allow for both complementarity and substitutability between individual and social motives in empirical analyses.
Developmental and functional heterogeneity of thermogenic adipose tissue
Authors: Ruan Hai-Bin 
Published: June 2020

Abstract
The obesity epidemic continues to rise as a global health challenge. Thermogenic brown and beige adipocytes dissipate chemical energy as heat, providing an opportunity for developing new therapeutics for obesity and related metabolic diseases. Anatomically, brown adipose tissue is distributed as discrete depots, while beige adipocytes exist within certain depots of white adipose tissue. Developmentally, brown and beige adipocytes arise from multiple embryonic progenitor populations that are distinct and overlapping. Functionally, they respond to a plethora of stimuli to engage uncoupling protein 1-dependent and independent thermogenic programs, thus improving systemic glucose homeostasis, lipid metabolism, and the clearance of branched-chain amino acids. In this review, we highlight recent advances in our understanding of the molecular and cellular mechanisms that contribute to the developmental and functional heterogeneity of thermogenic adipose tissue.
Spatial-Temporal Analysis ofLutzomyia trapidoiandLutzomyia reburra(Diptera: Phlebotominae), in Rural Tourist Locations, Biosphere Reserve and Leishmaniasis Endemic Area, Ecuador
Authors: Duque Paul L , Arrivillaga-Henríquez Jazzmín , Enríquez Sandra , Ron-Garrido Lenin , Benítez Washington , Navarro Juan-Carlos 
Published: June 2020

AbstractThis research represents the first attempt to assess the spatial and temporal distribution based on micro-meso scales on two species with different host preference habits (anthropophilic vs zoophilic), in the major Leishmaniasis endemic area in Ecuador, tourist locations, and Biosphere reserve. Phlebotomine species, Lutzomyia trapidoi (Fairchild) and Lutzomyia reburra (Fairchild and Hertig), were analyzed by trap/habitat/month/locality/altitude, through the Poisson generalized regression model. Our data reveal a bimodal pattern for both species related with low precipitations and preference for forest habitat. Altitude, proximity to the forest, and the river were the variables that determine the hypervolume of the spatial distribution of relative abundance, where the overlap of these two species increases the risk of translocation and circulation of the etiological agent of leishmaniasis in sylvatic environments to rural–tourist–biosphere reserve areas and vice versa. The ecological characteristics of these two phlebotomines could explain the permanence of the major active and endemic focus of cutaneous leishmaniasis in the North-Western Ecuador a key aspect in tourism health-security in alternative tourism.