bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Cardiovascular Effects of Controlled Exposure to Dilute Petrodiesel and Biodiesel Exhaust in Healthy Volunteers: A Crossover Study
Authors: Unosson Jon , Kabele Mikael , Boman Christoffer , Nyström Robin , Sadiktsis Ioannis , Westerholm Roger , Mudway Ian S , Purdie Esmie , Raftis Jenifer , Miller Mark , Mills Nicholas , Newby David E , Sandstrom Thomas , Blomberg Anders , Bosson Jenny 
Published: June 2020

Abstract
Background
Air pollution derived from combustion is associated with considerable cardiorespiratory morbidity and mortality in addition to environmental effects. Replacing petrodiesel with biodiesel may have ecological benefits, but impacts on human health remain unquantified.
Objectives
To compare acute cardiovascular effects of blended and pure biodiesel exhaust exposure against known adverse effects of petrodiesel exhaust (PDE) exposure in human subjects.
Methods
In two randomized controlled double-blind crossover studies, healthy volunteers were exposed to PDE or biodiesel exhaust for one hour. In study one, 16 subjects were exposed, on separate occasions, to PDE and 30% rapeseed methyl ester biodiesel blend (RME30) exhaust, aiming at PM 10 300 µg/m 3 . In study two, 19 male subjects were separately exposed to PDE and exhaust from a 100% RME fuel (RME100) using similar engine load and exhaust dilution. Generated exhaust was analyzed for physicochemical composition and reactive potential. Following exposure, vascular endothelial function was assessed using forearm venous occlusion plethysmography and ex vivo thrombus formation was assessed using a Badimon chamber technique.
Results
In study 1, PDE and RME30 exposures were at comparable PM levels (314 ±27 µg/m 3 ; (PM 10 ± SD ) and 309 ±30 µg/m 3 respectively), whereas in study 2, the PDE exposure concentrations remained similar (310 ±34 µg/m 3 ) , but RME100 levels were lower in PM (165 ±16 µg/m 3 ) and PAHs, but higher in particle number concentration. Compared to PDE, PM from RME had less oxidative potential.
Forearm infusion of the vasodilators acetylcholine, bradykinin, sodium nitroprusside and verapamil resulted in dose-dependent increases in blood flow after all exposures. V asodilatation to vasoactive infusions and ex vivo thrombus formation were similar following exposure to exhaust from petrodiesel and the two biodiesel formulations (RME30 and RME100).
Conclusions
Cardiovascular impairment did not differ following controlled exposure to biodiesel exhaust as compared to PDE, despite differences in PM composition and particle reactivity. We suggest that the potential adverse health effects of biodiesel fuel emissions should be taken into account when evaluating future fuel policies.
Transcriptome Profile of Hippocampus in Rats Model of Acute Myocardial Ischemia in Response to Electroacupuncture
Authors: Wu Xin , Wang Chenkai , Wang Kun , Cui Shuai , Wu Shengbing , Zhu Guoqi , Zhou Meiqi 
Published: June 2020

Abstract
Background: Electroacupuncture (EA) alleviates acute myocardial ischemia (AMI) by regulating some brain areas, including hippocampus. The locus coeruleus (LC) is the main source of norepinephrine (NE) in the brain, including the hippocampus, and regulates cardiovascular function. The aim of the present work was to assess whether LC mediates the positive effects of EA in AMI by altering gene expression levels in the hippocampus. We addressed this in the present study by hippocampus transcriptome profiling in a rat model of AMI following EA treatment. Results: Myocardial injury markers (ischemia-modified albumin, homocysteine and lipoprotein- associated phospholipase A2) in the serum were downregulated in EA (P<0.05) compared to the M group and upregulated in E+L group (P<0.05) compared to E group. RNA sequencing analysis of the hippocampus revealed that the downregulation of 27 genes in M vs S as well as upregulation of 40 genes in M vs S were reversed by EA. These differentially expressed genes, which were validated by quantitative real-time PCR, were enriched in 20 Kyoto Encyclopedia of Genes and Genomes pathways related to glycerolipid, glycerophospholipid, and arachidonic acid metabolism as well asnervous system function (glutamatergic, cholinergic, serotonergic, GABAergic synapses). Conclusions: LC mediates the beneficial effects of EA on AMI-induced injury may be related to the observed transcriptional regulations in the hippocampus. These results provide molecular-level evidence for the therapeutic efficacy of EA in the treatment of AMI.
Increasing Staff Compliance with Lone Worker Safety Devices
Authors: Barber David 
Published: June 2020

Abstract
BACKGROUND & AIMStaff working for the local community respiratory service were provided with lone worker security badges. Compliance across the service varied with some staff members using in line with the local policy, and others not, however overall compliance was reduced when compared to staff from an equivalent (control) community service. The purpose of this study was to evaluate a method to improve usage of these devices.METHODSA competition was devised whereby staff were randomised into one of four teams, and a scoring system implemented which averaged the number of recorded badge activations. A mystery prize for the end of the "season" was also promised for the winning "team", and monthly updates were provided to all participants. Data on device activation and usage was collected monthly by the author for analysis.RESULTSAverage device use per staff member comparing respiratory and control groups. Mean activations per month for the respiratory group exceeded the control group during the competition. Comparing with pre competition use, device activation's per month almost doubled during the competition for the respiratory service.CONCLUSIONSA small amount of admin (And an active imagination) were required, but resulted in a marked improvement in device compliance across the service.
Enhancing rhamnolipid production and exploring the mechanisms of low-foaming fermentation under weak-acid conditions
Authors: Gong Zhijin , Yang Ge , Che Chengchuan , Liu Jinfeng , Si Meiru , He Qiuhong 
Published: June 2020

Abstract
The commercialized applications of rhamnolipid has seriously impeded by high cost of production caused by severe foaming. Effective low-foaming fermentation and mechanism study have become the most urgent requirement for larger-scale production of rhamnolipid. In this study, the low-foaming fermentation was realized by controlling fermentation at pH 5.5. Further, the production of rhamnolipid was enhanced 0.9-fold by the ultraviolet and ethyl methanesulfonate composite mutagenesis. To the best of our knowledge, this was the first report to enhance production of rhamnolipid by strain improvement at weak-acid conditions. The mechanisms exploration tests indicated that increasing surface tension and decreasing viscosity were conducive to reduce foaming ability of rhamnolipid fermentation. The decrease of negatively charged ions may weaken the electrostatic repulsion between charged substances adsorbed membranes of bubbles such as rhamnolipid and cells, leading to the liquid membranes to rupture easily. In addition, the structure of vesicle or lamellar of rhamnolipid formed at pH5.0-6.0 may also weaken the foaming ability of rhamnolipid fermentation. The work revealed the promising potentiality for genetic modification to enhance the production of rhamnolipid and facilitated the understanding of pH-associated foaming behavior, as well as were conducive to develop a more effective pH-associated control strategies for large-scale production of rhamnolipid.
Programación de mantenimiento preventivo usando algoritmos genéticos
Authors: Montoya Arias Mario Enrique , Arango Marín Jaime Antero , Rosero Otero Silvio León 
Published: June 2020

En un sistema de mantenimiento preventivo programado por tiempo, se plantea la necesidad de optimizar el uso de los recursos del área de mantenimiento, para buscar un equilibrio a lo largo del periodo de planificación. El problema se refiere a la secuenciación de tareas en la que se requiere determinar la semana inicial del programa de mantenimiento para cada una de las actividades en las máquinas. Se propone un algoritmo genético que tiene como función objetivo minimizar el máximo tiempo de mantenimiento semanal, de tal manera que cumpla con las condiciones de la programación establecida en cuanto a duraciones y frecuencias. Se consigue un programa eficiente y equilibrado que mejora significativamente el uso de los recursos. Para futuros trabajos, se sugiere aplicar otras técnicas inteligentes para la solución del problema y formularlo teniendo en cuenta otras condiciones, como los diferentes tipos de mantenimiento o la minimización de las paradas frecuentes de los equipos.
Assessment of the Impact of Media Coverage on COVID-19–Related Google Trends Data: Infodemiology Study
Authors: Sousa-Pinto Bernardo , Anto Aram , Czarlewski Wienia , Anto Josep M , Fonseca João Almeida , Bousquet Jean 
Published: June 2020

Background
The influence of media coverage on web-based searches may hinder the role of Google Trends (GT) in monitoring coronavirus disease (COVID-19).

Objective
The aim of this study was to assess whether COVID-19–related GT data, particularly those related to ageusia and anosmia, were primarily related to media coverage or to epidemic trends.

Methods
We retrieved GT query data for searches on coronavirus, cough, anosmia, and ageusia and plotted them over a period of 5 years. In addition, we analyzed the trends of those queries for 17 countries throughout the year 2020 with a particular focus on the rises and peaks of the searches. For anosmia and ageusia, we assessed whether the respective GT data correlated with COVID-19 cases and deaths both throughout 2020 and specifically before March 16, 2020 (ie, the date when the media started reporting that these symptoms can be associated with COVID-19).

Results
Over the last five years, peaks for coronavirus searches in GT were only observed during the winter of 2020. Rises and peaks in coronavirus searches appeared at similar times in the 17 different assessed countries irrespective of their epidemic situations. In 15 of these countries, rises in anosmia and ageusia searches occurred in the same week or 1 week after they were identified in the media as symptoms of COVID-19. When data prior to March 16, 2020 were analyzed, anosmia and ageusia GT data were found to have variable correlations with COVID-19 cases and deaths in the different countries.

Conclusions
Our results indicate that COVID-19–related GT data are more closely related to media coverage than to epidemic trends.
ANALISIS PERSEPSI MASYARAKAT MUSLIM DAN NON MUSLIM TERHADAP KESIAPAN DESTINASI WISATA SYARIAH DI KOTA PEKANBARU DAN PADANG
Authors: PUTRIANA PUTRIANA PUTRIANA 
Published: June 2020

Penelitian ini betujuan untuk mengetahui persepsi masyarakat muslim dan non muslim terhadap kesiapan destinasi wisata syaraih di kota Pekanbaru dan Padang. Permasalahan dalam penelitian ini adalah bagaimana persepsi masyarakat Kota Pekanbaru dan Padang tentang kesiapan masing-masing destinasi wisata syariah.Populasi adalah masyarakat di Kota Pekanbaru dan Padang dengan jumlah sampel sebanyak 100 orang dengan metode accidental sampling Variabel dalam penelitian ini adalah persepsi maysrakat terhadap kesiapan destinasi wisata syariah. Tekhnik analisa data mengunakan deskriptif dengan mendapatkan hasil kesiapan Pekanbaru menjadi destinasi wisata syariah adalah baik yang dilihat beberapa indikator utama yaitu: daya tarik wisata dan infastruktur dan Pekanbaru berpotensi untuk dikembangkan sebagai destinasi wisata syariah dan persepsi masyarakat Kota Padang Sumatera Barat telah siap menjadi destinasi wisata yang banyak mengandung unsur religi.
DESAIN IN SILICO DNA PROBE PENDETEKSI MUTASI DAERAH RESISTENSI QUINOLON Gen gyrA DAN gyrB Mycobacterium tuberculosis
Authors: Pramiswari Tasya , Tamara Jennifer , Febrianti Ni Made , Chandra Yowani Sagung 
Published: June 2020

Fluoroquinolone (FQ) is the main drug used in MDR-TB therapy resistance to FQ can cause death and increase the risk of treatment failure in MDR-TB patients. Mutations in gyrA gene and gyrB gene from Mycobacterium tuberculosis are responsible for the occurrence of FQ resistance. The highest mutation of gyrA gene in QRDR was found in codon 94, while mutations in gyrB gene was found in codon 500. M. Tuberculosis which resistant to FQ can be detected using the Real Time Polymerase Chain Reaction (RT-PCR) method with DNA probe.
This study will design the nucleotide sequence of the TaqMan type probe using the Clone Manager Suite 9.2 program. The results of the DNA probe design were then analyzed in two stages, which is based on the probe criteria in general and based on the TaqMan probe labeling criteria. The design of the mutant probe DNA using the program produced 1 probe for Asp94Ala specific mutations in the gyrA gene and 33 probes for Asp500Ala specific mutations in the gyrB gene. After being analyzed by the two criteria, it was obtained the A94MA1 probe with the 5 '-TCGATCTACGCCAGCCTGGT-3' sequence and B500MA12 probe with the order of 5 '-TACCACAAGCTCGTGCTGATGGC-3'. The results of these probes meet both criteria and can be used to detect mutations in codon 94 gyrA genes and codons 500 gyrB genes of Mycobacterium tuberculosis.
THE EFFECT OF PEDAL EXERCISE AND STRETCHING CALF MUSCLES MORE EFFECTIVE TO INCREASE THRESHOLD OF CALF MUSCLE PAIN ON THE FABRIC CUTTERS WORKER IN KEDIRI TABANAN
Authors: Sari Ni Putu Ayu Sasmita , Winaya I Made Niko , Griadhi I Putu Adiartha , Adiatmika I Putu Gede 
Published: June 2020

ABSTRACT Stands work attitude in a long time cause muscle complaints on fabric cutters worker. The purpose of this studyis knowing whether effect of pedal exercise and stretching calf muscles more effective to increase threshold of calfmuscle pain on the fabric cutters worker. Measurement of the value of pain was measured using a sphygmomanometerThis study is experimental research using Pre Test and Post Test Control Group Design. These samples included 20people who were divided into group treatment and group control. Group treatment was given pedal exercise andstretching calf muscles, while Group control without treatment. Hypothesis test by paired sample t-test in group treatmentis p=0.000 with a mean difference 30.00±16.99, that mean is it can increase threshold of calf muscle pain, while incontrol group is p=0.758 with a mean difference 1.00±9.94, that mean is it can’t increase threshold of calf muscle pain.At different test between treatment group and control group using independent sample t-test was obtained p=0.000(p<0.05). Based on these results, it can be concluded that pedal exercise and stretching calf muscles more effective toincrease threshold of calf muscle pain.
Keywords: pedal exercise, stretching, calf muscle pain, fabric cutter
THE THE RELATIONSHIP BETWEEN PROLONGED STANDING AND HALLUX VALGUS IN SALESPERSON
Authors: Pratiwi Galuh Aullia , Winaya I Made Niko , Primayanti Dewa Ayu Inten 
Published: June 2020

ABSTRAK
Hallux valgus is a condition if first metatarsal medial deviation and thumb or hallux lateral deviation and rotation. Factor that affected was the prolonged standing use of constrictive footwear such as high-heeled shoes. Prolonged standing was standing with more than 4 hours per day.This study was cross sectional analytic observation and 62 female salesperson who worked in Mall X were selected to be sample. Measuring instruments used to determine the hallux valgus was using the Manchester scale. This study was shown there wes a significant relationship between prolonged standing and hallux valgus in female salesperson p = 0.007 (p <0.05). From 62 female salesperson, the were 46 who had hallux valgus, in which 43 persons worked with longterm standing (93.5%) and 3 persons (6.5%) worked without longterm standing. However, from 16 salesperson who had not hallux valgus, there was 10 persons (62.5%) worked with longterm standing and 6 persons worked without longterm.
Keywords : Hallux valgus, Prolonged standing, salesperson
THE COMPARISON OF MUSCLE ENERGY TECHNIQUE AND INFRARED INTERVENTION WITH CONTRACT-RELAX STRETCHING AND INFRARED IN IMPROVING RANGE OF MOTION NECK JOINT ON ONLINE GAME PLAYERS WITH MYOFASCIAL PAIN SINDROME UPPER TRAPEZIUS MUSCLE IN DENPASAR
Authors: Arthawan Made Aditya Prawira , Wahyuni Nila , Artini I Gusti Ayu 
Published: June 2020

ABSTRACT

Pain is most commonly caused by myofascial pain syndrome, myofascial pain syndrome pain can affect the flexibility of the joints that will cause a decrease range of motion neck joint. The purpose of this study was to determine the comparison between muscle energy technique and infrared with contract relax stretching and infrared in increasing the range of motion neck joint on online game players with myofascial pain syndrome upper trapezius muscle in Denpasar. This research is an experimental research with pre and post test design group control design. The sample is an online game player of 22 people divided into two groups. Group 1 was given intervention of muscle energy technique and infrared, while group 2 was given contract relax stretching and infrared intervention. Result of hypothesis test with paired t-test, group 1 got difference average 6,36 ± 0,62 (p = 0,000) while group 2 got difference mean 5,00 ± 0,357 (p = 0,000). Differential test of improvement after group 1 and group 2 treatment using independent sample t-test showed that group 1 increase was higher than group 2 and this result was significantly different p = 0,019 (p <0,05)
Keywords: Range of motion neck joint, myofascial pain syndrome, contract relax stretching, infrared
THE DIFFERENCES MUSCULOSKELETAL DISORDER BETWEEN WOOD CARVERS AND PAINTERS IN UBUD
Authors: Patmala Ni Kadek Citra , Dewi Anak Ayu Nyoman Trisna Narta , Muliarta I Made 
Published: June 2020

ABSTRACT

Work activity can cause pain, pain, stiffness and other disorders of the muscular system which is one of the musculoskeletal complaints. Wood carvers and painters are workers who still dominant work with the manual system.The purpose of this study was to know the difference of musculoskeletal disorder between woodcarvers and painters and to justify the hypothesis of purpose that has been formulated.This research was observational research, categorical analytics unpaired with cross sectional approach. Sampling technique in this research was simple random sampling. The sample of this study amounted to 96 people divided into 2 groups, namely groups of wood carvers and painters. Data collection was done by filling the Nordic Body Map questionnaire. Statistical test using Chi-Square and Independent T-test. The results showed significant differences in musculoskeletal disorder on wood carver and painter, with woodcarvers mean value of 40,7 ± 5,3 and painters mean value of 43,2 ± 6,2, so p = 0,038 (p <0,05) , then there are differences in musculoskeletal disorder among woodcarvers and painters, where musculoskeletal disorders at greater painter than woodcarver. Analysis of the difference each extremity musculoskeletal disorders in the upper extremities get results with woodcarvers mean value of17.1 ± 0.38 and painters mean value of 17,3 ± 2,5, so p= 0,692 (p> 0,05), on the trunk with woodcarvers mean value of 8,3 ± 1,69 and painters mean value of 10,5 ± 2,50, so p = 0,000 (p <0,05) and in the lower extremities with woodcarvers mean value of 15,1 ± 2,69 and the average value of the painters 15.1 ± 3.33, so p = 0.973 (p> 0.05). The results of the analysis of each extremity musculoskeletal disorders in woodcarvers and painters, it can be concluded that there are significant differences in musculoskeletal disorder among woodcarvers and painters on the trunk and there are no significant differences in musculoskeletal disorder among woodcarvers and painters in the upper extremities and the lower extremities.

Keywords: muskuloskeletal disorder, Nordic body map, wood carver, painter
THE SLEEP QUALITY DIFFERENCES IN ADULTS WHO PARTICIPATE THE AIKIDO MARTIAL ARTS WITH ADULTS WHO NO PARTICIPATE THE AIKIDO MARTIAL ARTS IN BALI
Authors: Imaniyah Fitrotul , Winaya I Made Niko , Sugiritama I Wayan 
Published: June 2020

ABSTRACT

The addition of age and the variation of physical activity of each individual will increase the stress affecting the quality of sleep so that research done to determine the quality of sleep in adults who participateaikido martial arts with adults who noparticipateaikido martial arts as physical activity that can reduce stress level. The cross sectional analytic study with the sample was adults who fulfilled the inclusion and exclusion criteria of 86 people in each group. Samples filling out the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the results were tested with a fisher exact test. The results showed a significant difference between sleep quality in two groups (p <0.05). With the percentage of result that is group A has good sleep quality 82 people (95,3%) and bad 4 people (4,7%), group B have good sleep quality 59 people (68,6%) and bad 27 people (31, 4%). So the conclusion is that groups of adults who participateaikido martial arts have better sleep quality than adults who no participate aikido martial arts.

Keywords: Adult, Stess, Sleep Quality, Aikido Martial Arts.
THE RELATIONS BETWEEN WORKING POSITION WITH NON-SPECIFIC NECK PAIN ON LAUNDRY WORKERS IN DENPASAR CITY
Authors: Dewi Ni Made Wahyuni , Wahyuni Nila , Sundari Luh Putu Ratna 
Published: June 2020

Non-specific neck pain is a neck pain caused by bad posture in the long term. Laundry workers who everyday often perform activities ironing for a long time at risk of non-specific neck pain due to working position that are not ergonomic. The purpose of this research is to determine the relation between working position with non-specific neck pain on laundry worker in Denpasar City. This research is cross sectional analytic research with purposive sampling. The number of sample is 60 workers with the range of age 20-40 years. Independent variable measured is working position with RULA method, while the dependent variable measured is non-specific neck pain with Neck Disability Index Questionnaire. Hypothesis test used is Chi-Square Test. The resulted of Chi-Square Test on working position with non-specific neck pain variable shown the result of p value is 0,00 or p < 0,05. Based on the results of this study it can be concluded that found a significant relationship between working position against non-specific neck pain on laundry worker in Denpasar City.
Keywords: Working Position, Non-Specific Neck Pain, Laundry Worker.
THE RELATION BETWEEN SITTING POSITION AND NON-SPECIFIC LOWER BACK PAIN IN THE ADMINISTRATION AND SERVICE DEPARTMENT OF POLDA BALI
Authors: Melani Inne , Saraswati Putu Ayu Sita , Wahyuni Nila 
Published: June 2020

Occupational disease (PAK) found in office workers is non-specific lower back pain. Non-specific lower back pain is one of the most common disorders of musculoskeletal disorders (MSDs) with the major symptoms of pain or discomfort in the lower spine, where one of the causes is an ergonomic sitting position. The purpose of this study was to determine the relationship of sitting position with non-specific lower back pain in the administration and service department of Polda Bali. This research was analytical research using cross sectional approach. In 71 samples, from the calculation of data by using Spearman's rho, it is found that the significance value p < 0,05 and the correlation coefficient was -0,282 which mean it possess sufficient relation and negative relation direction. Based on the results of this study it can be concluded that there is a significant relation between sitting position and non-specific lower back pain in the administration and service department of Polda Bali.
Keywords: Sitting position, Non-specific lower back pain, Occupational disease