bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Retrospective Review of the Contribution of Rare Diseases to Paediatric Mortality in Ireland
Authors: Gunne Emer Anne , McGarvey Cliona , Hamilton Karina , Treacy Eileen , Lambert Deborah , Lynch Sally Ann 
Published: April 2020

Abstract
Aims: To ascertain the number of paediatric deaths (0-14 years) with an underlying rare disease (RD) in the Irish Republic between the years 2006-2016, and to analyse bed usage by a paediatric cohort of RD inpatients prior to in-hospital death. Background: Rare Diseases are life-threatening or chronically debilitating diseases that affect fewer than 5 per 10,000 people in the EU. Although individually rare, collectively RDs are common, with a prevalence of 3.5-5.9% of the population. Under representation of RDs in hospital healthcare coding systems leads to a paucity of RD epidemiological data required for healthcare planning. Studies have cited variable incidence rates for RD, however the burden of RDs to healthcare services still remains unclear. This study represents a thorough effort to identify the percentage of child mortality and paediatric bed usage attributable to rare diseases in Ireland addressing a major gap in the RD field. Methods: Retrospective analysis of paediatric death registration details for the Irish Republic in the 11-year period 2006-2016 from the National Paediatric Mortality Register. Data was subcategorized as Neonatal (0-28 days), Post Neonatal (29 days < 1 year) and older (1-14 years). Bed usage data (ICD-10 code, narrative and usage) of paediatric inpatients who died during hospitalisation from January 2015 to December 2016 was extracted from the National Quality Assurance Intelligence System of in-patient data. Orphacodes were assigned to RD cases from narrative records of both datasets. Results: There were 4044 deaths registered from 2006-2016, aged <15yrs. 2368 (58.6%) had an underlying RD. Stratifying by age group; 55.6% (1140/2050) of neonatal deaths had an RD, 57.8% (450/778) post-neonatal, and 64% (778/1216) of children >1yr. Mortality coding using ICD-10 codes identified only 42% of RD cases with the remainder identified using death certificate narrative records. RD patients occupied 84% of bed days used by children <15 years discharged deceased in the analysis period January 2015 to December 2016. Conclusion: Additional routine RD coding is necessary to identify RDs within Irish healthcare systems to enable better healthcare planning. RD patients are overrepresented in paediatric mortality statistics and inpatient length of stay during hospital admission prior to death.
Rare musculoskeletal diseases in adults: a research priority setting partnership with The James Lind Alliance
Authors: Mickute Gerda , Staley Kristina , Delaney Heather , Gardiner Oliver , Hunter Amy , Keen Richard , Lockhart Lorraine , Meade Nick , Newman Maria , Ralston Stuart , Rush Elaine , Upadhyaya Sheela , Regan Sandra , Watts Laura , Walsh Jennifer , White Paul , Francis Roger M , Javaid M Kassim 
Published: April 2020

Abstract
Background: Osteogenesis imperfecta, fibrous dysplasia/McCune-Albright syndrome and X-linked hypophosphatemia are three rare musculoskeletal diseases characterised by bone deformities, frequent fractures and pain. Little high-quality research exists on appropriate treatment and long-term management of these conditions in adults. This is further worsened by limited research funding in rare diseases and a general mismatch between the existing research priorities and those of the patients. This partnership adopted the James Lind Alliance approach to identify the top 10 research priorities for rare musculoskeletal diseases in adults through joint patient, carer and healthcare professional collaboration. Results: The initial survey for question collection recruited 198 respondents, submitting a total of 988 questions. 77% of the respondents were patients with a rare musculoskeletal disease. Following out-of-scope question exclusion, repeating query grouping and scientific literature check for answers, 39 questions on treatment and long-term management remained. In the second public survey, 220 respondents, of whom 85% were patients with a rare musculoskeletal disease, their carers, relatives or friends, prioritised these uncertainties, which allowed selection of the top 25. In the last stage, patients, carers and healthcare professionals gathered for a priority setting workshop to reach a consensus on the final top 10 research priorities. These focus on the uncertainties surrounding appropriate treatment and holistic long-term disease management, highlighting several aspects indirect to abnormal bone metabolism, such as extra-skeletal symptoms, psychological care of both patients and their families and disease course through ageing. Conclusions: This James Lind Alliance priority setting partnership is the first to investigate rare bone diseases. The priorities identified here were developed jointly by patients, carers and healthcare professionals. We encourage researchers, funding bodies and other stakeholders to use these priorities in guiding future research for those affected by rare musculoskeletal disorders.
Detection of Coronavirus in Simultaneously Collected Tear and Throat Swab Samples from the Patients with 2019- new Coronavirus Infection Disease: A Single Center Cross-sectional Study
Authors: Yan Ying , Zeng Bo , Zhang Zhang , Hu Cheng , Yan Ming , Li Bixi , Zhang Xiaopeng , Chen Xiao 
Published: April 2020

Abstract
Objecive: This study aimed to evaluate whether the coronavirus can be detected in the tears in the eyes of 2019- novel coronavirus (2019-nCoV) infected patients and compa re the detection consistency of two simultaneously collected samples, from the tears and throat swabs, of these patients.Methods: A total of 35 diagnosis confirmed patients with 2019-nCoV infection disease,from January 26 to February 19, 2020, at central theater Wuhan general hospital of PLA, were included in this cross-sectional case series study. The diagnosis was confirmed by both clinical and laboratory ways. Throat samples from all enrolled patients were collected with sampling swab, and simultaneously ,tear samples were collected w ith sampling swab from 9 patients (No.1-9) and with Schirmer's strip from the remaining patients (No.10-35) (bilateral eyes for all patients). Sample collecting and testing were performed in three separate time points: first from patients No.1-9,second from p atients No.10-29,and third from patients No.30-35. Reverse-transcriptase-polymerase-chai n-reaction (RT-PCR) assay was performed by the same technician(Researcher Zhang), who was blind to the patients profile, within 4 hours after each collection.Results: Among enrolled patients, 29 (No.1-29) had mild or moderate clinical symptoms and 6 (No.30-35) had severe symptoms. The mean time interval from the sample collection day to diagnosis confirmation day was 9.71±6.50 days (ranged from 3 to 29 days). None of the patients had conjunctivitis. Nineteen out of 35 (54.3%) throat samples presented positive Rt-PCR results. Three (no.13,21,31) out of 35 (8.6%) tear samples presented positive RT-PCR results. Two(no.21, 31) of these three patients were throat swab positive and one (No. 13) was negative. The consistency analysis indicated that tears and throat samples showed poor consistency ( Kappa=-0.009, P=0.9 ).The cycle threshold value (Ct-value) of tears samples collected by sampling swab was significantly higher than that by Schirmer's strip(t=2.288, P=0.03).Conclusion: In spite of the low 2019-nCoV positive detection rate of tear samples from 2019-nCoV infected patients, we cannot fully rule out the transmission by ocular surface. Whether tear testing can be used as an aid in judging of 2019-nCoV infection need further investigation.Authors Ying Yan and Bo Zeng contributed equally to this study
System analysis and mathematical modeling of the disease caused by the 2019-nCoV coronavirus strain
Authors: Kostarev S N , Tatarnikova N A , Kochetova O V , Sereda T G 
Published: April 2020

Abstract
A particular problem at the beginning of the second millennium is the epidemic caused by coronaviruses. In 2002-2003, new strains of viruses appeared – SARS-CoV SARS, in 2012, MERS-CoV. In 2019-2020, the epidemic caused by the coronavirus strain 2019-nCoV, which belong to the Beta-CoV group, is a threat. Different types of coronaviruses infect humans, cats, birds, dogs, cattle, pigs and hares, bats, camels and other animals. Coronaviruses have a single-stranded RNA genome, which encodes 4–5 structural proteins, including proteins of the outer membrane, matrix and small membrane. The complete 2019-nCoV genome is stored online at GenBank: MN908947.3. Coronaviruses have some unique features in RNA transcription. The RNA minus chain serves as a matrix for the synthesis of both new genomic and subgenomic RNAs. To develop a model of human resistance to the disease caused by the coronavirus family, elements, connections and ways of protecting the Human-Virus-Environment system were identified. The destructive functions of sixteen non-structural and structural proteins of the strain 2019-nCoV are considered. Deterministic and statistical models of the development of the danger of infection of the cells have been developed. A parameterized system for protecting a person from coronavirus damage has been developed.
Marriage under the age of legal perspective on Sasak tribe in Indonesia
Authors: Ihsan Ihsan 
Published: April 2020

The existing tradition of marriage under age (Merariq Kodeq), this research aims to understand the consciousness of the national law, which prevails in the middle of the community with the existence of the marriage laws related to the age of marriage. This study used a qualitative approach to know the factors causing, the form of offense, impact, and effort of government in marriage underage in the Parampuan village Lombok Barat regency. The study results are as follows. Factors affect the Merariq Kodeq among the others because of the low financial of a family, factors of low public education, personal factors influenced by environment intercommunication, factors parental concern to the intercommunication of his son, cultural factors that still adopted the community. Abuses that are not in accordance with the provisions of the constitution based on Indonesian law system marriage, which the age of children in doing marriage, the validity of marriage did not participate noted in the office of religious affairs—the rights of the child and teenage as the young generation. The impact of that occurs as a result of Merariq Kodeq is premature pregnancy, dropping out of school, domestic violence, divorce, psychological trauma as well as vulnerable to marriage in below the hands. The government commitment to socializing in the village, guidance, the documentary movie about the dangers of marriage on the below age, and the information center for counseling sex education for teenagers.
The implementation of block-system learning on the expertise competence of automotive lightweight vehicle engineering in vocational high school
Authors: Burhan Nurul , Arifin Zainal 
Published: April 2020

The objective of this study was to understand the following: (1) the effectiveness of block system learning to student learning outcomes. (2) the diffrences in student learning outcomes between those who use block and non-blok learning system in public vocational high schools in Batang District. This study includes a type of descriptive quantitative research with a survey approach. Data were collected through observation, interview, and documentation. The population is the whole school vocational high schools in Batang District. This research uses purposive sampling consisting of three vocational high schools. The result showed that: (1) the effectiveness of block system learning in vocational high school in Batang District can be seen of the result students that average value of expertise competency test (UKK) has meet the minimal completeness criteria (KKM) specified by the school at 75.00. In SMK Negeri 1 Warungasem, the average UKK value in the 2017/2018 academic year was 76.83, increasing to 82.32 in the 2018/2019 academic year with an increase of 5.4. Furthermore, in SMKN 1 Blado, UKK value average in the 2017/2018 school year amounted to 77.48, rising to 81.81 in the 2018/2019 school year with an increase of 4.3.(2) the comparison of student learning outcomes between the use of block and non-block system learning in the TKRO major at public vocational high schools in Batang District seen from the average UKK grades for the 2018/2019 school year that the use of block system learning is superior to non-block system learning.
Pengembangan Bahan Ajar Multimedia Interaktif pada Praktikum Titrasi Asam Basa
Authors: Oktiarmi Peri , Rusdi Muhammad , Asrial Asrial 
Published: April 2020

The objective of the research is to develop a class xi chemistry instructional medium the topic of acid-base titration with the orientation of improving the students skill of scientific process in the laboratory. The research is a developmental research and the model used is ADDIE, which stand for Analyze, Design, Develop, Implement and Evaluate. Having been validated by some assessors and teachers, the medium developed proves adequate and can be implemented among class xi high school students. The result of the reaserch show that the student respon well to the implementation of the medium. The medium can be used by student with various capabilities : however, among weak students teacher’s guidance is needed.
Pengembangan Perangkat Pembelajaran Berbasis TPACK pada Materi Sifat Koligatif Larutan untuk Meningkatkan Keterampilan Berpikir Kritis Siswa
Authors: Mairisiska Titin , Sutrisno Sutrisno , Asrial Asrial 
Published: April 2020

TPACK based learning devices development research on the colligative properties is intended to develop Lesson Plan (RPP) and student’s activity sheets (LKS) in the form of a flip page ebook, apply the RPP and LKS and analyze the relationship among components of TPACK compiler. This research done by applying 4D Thiagarajan, Semmel and Semmel Model, that has been modified. The results indicated on learning activities at the meeting I 92%, meeting II dan III 93,4%, meeting IV dan V 86,7%, meeting VI 86,1%, meeting VII 91,4%, all of them belong to the category of “highly optimized”. Students gave positive responses to the learning and products developed. The average percentage of student’s critical thinking skills as a whole is 66.3% which includes the category of “good”.
Pengembangan Kerangka Kerja TPACK pada Materi Koloid untuk Meningkatkan Aktivitas Pembelajaran dalam Mencapai HOTS Siswa
Authors: Hayati Dwi Kurnia , Sutrisno Sutrisno , Lukman Aprizal 
Published: April 2020

Chemistry learning particularly colloid material has a scientific topic that measuring up to abstract and emphasizes the mastery of concepts until the microscopic level (molecular) symbolic. Thus, the implementation of learning need to be completed. Up till now, chemistry learning process is still dominantly conventional in teacher-centered, so that the students tend to be passive and less interested in learning. Therefore, it is necessary to develop an innovative learning to improve student’s learning activities, by integrating Technology, Pedagogy, and Content Knowledge (TPACK). Through the integration of TPACK, abstract material can be concrete with the use of simulation, as well as the learning will be student-centered learning by means of Inquiry Based Learning (IBL) model, so that students are more active in their learning and students’ Higher Order Thinking Skills (HOTS) will be achieved. The results indicating that learning activities at the meeting I 96.25%, meeting II 92.98%, meeting III 95.29%, and meeting IV 91.18% , all of them belong to the category of "highly optimized". Student test scores on average 64.6 which belong to the category of "quite".
Pengembangan Bahan Ajar Kimia SMK Teknologi Kelas X Berbasis Kontekstual
Authors: Asliyani Asliyani , Rusdi Muhammad , Asrial Asrial 
Published: April 2020

This development research is conducted at SMKN 3 Jambi, the purpose is to develop contextual based chemistry learning material for Xth grade Technological Vocational High School (SMK) with content and contex representative enough for SMKN 3 students. The model used in this research development is the type 1 development mode from Richey by adopting the development model of Dick & Carey. This development research is conducted in four important steps, they are analysis, design, development, and evaluation. The data are collected using openended questionaire. The subjects are students from class X TPM1, X TKR2, and X TKR3. These samples are taken randomly but remain to represent each student ability level, high, medium and very low. The research result shows the positif respond towards the developed product. Based on the collected and analyzed data, it can be concluded that the developed product is interesting, simple and easy to understand, can increase student’s positif characters such as interest, participation, responsibility, and relate to student selected skill.
Konstruksi Skala Sikap terhadap Pelajaran Matematika dan Sains
Authors: Periantalo Jelpa , Fadzlul Fadzlul , Saputra Eka 
Published: April 2020

Student attitude toward subject is strong predictor for academic successful. Student with positive attitude shows good academic achievement and attitude poor achievement. Earlier information about student attitude can optimilize academic successful. Education stake holders can change attitude. Therefore, it needs a measurement to know student attitude toward subject. The purpose of research is to construct scale attitude toward Mathematics and Natural Sciences subject. Instrument should be valid, reliable, and discriminative and practice. Research used psychological measurement method. It used 185 high school students for subject. It used semantif differential method in scale (1-7). There were 68 items in scale. Factorial validity confirmed three factor construct a scale. Convergent validity showed there was positive correlation among scale component. Scale had internal consistency reliability 0,84 and test parallel reliability 0,92. All items had discrimination power D > 4,00. Final scale uses 12 items. Instruction and scoring can be done easily. Scale has good psychometric properties. It has good validity, satisfied reliability, high discrimination power for items, and practice in used.
Pengaruh Penerapan Model Pembelajaran Group Investigation dan Motivasi Terhadap Hasil Belajar Siswa Kela VII SMP Dalam Pembelajaran IPA Terpadu Pada Materi Asam, Basa dan Garam
Authors: Pransiska Susy , Asyhar Rayandra , Asrial Asrial 
Published: April 2020

This research aimed to determine the effect of group investigation learning model and motivation on the students' learning result. The research employed a quasi experimental research with nonrandomized control group pretest-posttest design. The research used factorial design of 2x2. The population of this research was the first semester of seventh grade students. The sample used VII A and VII B class, samples were taken by using purposive sampling. The learning result data measured using of the tests and motivation data using of questionnaires. The data are analyzed using two-way(s) ANOVA. Test analysis showed that difference between post-test score of experiment class were higher than the control class. Based on the result, it can be concluded that: 1) the implementation of the group learning model investigation affect the students’ learning result, 2) motivation also influences the student learning result. 3) There is no interaction between the group investigation learning model and motivation on the students' learning achievement. Keywords: Group Investigation, Motivation and Learning Result.
Pengembangan Modul Elektronik Dengan Pendekatan Saintifik Materi Sistem Peredaran Darah Pada Manusia Untuk Siswa Kelas VIII
Authors: Zaharah Zaharah , Yelianti Upik , Asra Revis 
Published: April 2020

Abstrak
Penelitian dan pengembangan ini bertujuan untuk: 1) Menghasilkan modul elektronik yang memenuhi aspek kesesuaian isi dengan kurikulum, penyajian materi dan keterbacaan. 2) Menguji kelayakan modul elektronik dengan pendekatan saintifik yang dibuat dengan memperhatikan prinsip pengembangan module ekronik melalui validasi dan ujicoba pada siswa kelas VIII. 3) Mengetahui respon siswa terhadap module ektronikdengan pendekatan saintifik materi system peredaran darah pada manusia untuk kelas VIII SMP. 4) Mengetahui respon guru terhadap modul elektronik dengan pendekatan saintifik materi system peredaran darah pada manusia untuk kelas VIII SMP. Penelitian ini menggunakan pendekatan R&D (research and development/penelitian dan pengembangan) dengan menggunakan model Lee dan Owen, dengan langkah 1) Analysis, 2) Design, 3) Development, 4) Implementation dan 5) Evaluation (ADDIE). Penelitian pengembangan ini menghasilkan modul elektronik menggunakan 3D PageFlip Professional pada materi sistem peredaran darah pada manusia, berdasarkan hasil validasi dan ujicoba memperoleh kriteria “sangat baik”. Maka dapat dikatakan bahwa modul elektronik yang dikembangkan sudah layak digunakan sebagai bahan ajar untuk siswa kelas VIII SMP.
Pengembangan Multimedia Biologi pada Materi Sistem Pencernaan Manusia Berbasis Macromedia Flash untuk Siswa Kelas VIII SMP
Authors: Anwar Handra , Damris Damris , Yelianti Upik 
Published: April 2020

Abstract
Good multimedia is a simple and easy to understand so it can be a tool to increasing the interest of students especially in subject that required visualization. This research aim to develope the interactive learning multimedia using Macromedia Flash for students grade VIII human digestive system subject. The model used in this research is ADDIE developing model. The ADDIE developing model have some procedure such as Analyze, Design, Development, Implementation and Evaluation.The result of this research is a product of Biology learning Multimedia designed by Macromedia Flash and developed under ADDIE model. Developing proccess have some shortages. From validation step, media expert given the shortage from text, communicative powe, practice test and narrator voice with score 50 and 66,7% (phase I) and in phase II 71 and 94,7%. Content expert found that acontent is not complete, description picture still not clear and leak of practice test with score in phase I, II and III are 33 (60%), 40 (72,7%) and 47 (85,5%). In field test, most of students and teachers response found that product deserves to be used in classroom with score percentage for small group, large group and teachers are 95,2%, 85,6% dan 80%.
Pengembangan Modul Pembelajaran Berbasis Kontekstual pada Materi Ekosistem untuk Siswa Kelas VII SMP Al-Falah Kota Jambi
Authors: Yuliana Yuliana , Anggereini Evita , Hamidah Afreni 
Published: April 2020

Abstrak
Penelitian ini bertujuan mengembangkan modul pembelajaran berbasis kontekstual pada materi ekosistem, untuk mengetahui cara pengembangan modul, serta untuk mengetahui tanggapan guru dan siswa terhadap modul pembelajaran berbasis kontekstual pada materi ekosistem. Pengembangan ini mengikuti model 4D. Validasi desain modul oleh ahli desain sebanyak 2 tahapsementara validasi modul oleh ahli materi sebanyak 3 tahap.Selain itu, diperoleh skor penilaian guru saat uji coba adalah sebesar 82 dengan persentase 82% kategori sangat baik. Di sisi lain respon siswa perorangan terhadap modul diperoleh skor sebesar 50,6 dengan persentase 84,3% dengan kategori sangat baik. Dan respon siswa kelompok kecil terhadap modul diperoleh skor sebesar 52,8 dengan persentase 88% kategori sangat baik. Berdasarkan proses dari validasi ahli hingga uji coba perorangan dan kelompok kecil pada siswa di SMP Al-Falah Kota Jambi, secara keseluruhan modul pembelajaran berbasis kontekstual ini dikategorikan sangat baik untuk digunakan dalam pembelajaran.