bluuebunny/crossref_metadata_2025_split huggingface dataset:
КОНТРФАКТИЧЕСКОЕ МОДЕЛИРОВАНИЕ ПРОШЛОГОВ ОБЫДЕННОМ ПОЗНАНИИ: УРОКИ ДЛЯ УЧЕНОГО
Authors: Нехамкин А.Н. , Нехамкин В.А. 
Published: December 2024

В статье рассматриваются особенности контрфактического моделирования прошлого применительно к обыденному познанию. Выявляются идеи, лежащие в основе выдвижения альтернативных исторических гипотез и создания описаний потенциального прошлого. Намечаются перспективы совершенствования данной методологии.
This article discusses the features of counterfactual modeling of the past in relation to everyday knowledge. The ideas underlying the nomination of alternative historical hypotheses and the creation of descriptions of the potential past are revealed.
НАПОЛЕОНОВСКИЕ ВОЙНЫ И ПЕРВАЯ МИРОВАЯ ВОЙНАВ ПОЛИТИКЕ ПАМЯТИ И ИСТОРИЧЕСКОЙ ПАМЯТИ НАРОДОВразмышления российских и зарубежных историков
Authors: Поршнева О.С. 
Published: December 2024

Статья посвящена анализу проблематики докладов, представленных на международном научном семинаре, рассмотрению ключевых аспектов размышлений участников дискуссии. В центре внимания – оценки и выводы ведущих специалистов, характеризующие механизмы формирования исторической политики и исторической памяти о наполеоновских войнах и Первой мировой войне.
The article is devoted to the analysis of the problems presented at the international seminar, to the consideration of key aspects of the reflections of the participants in the discussion. The focus is on the assessments and conclusions of leading experts, characterizing the mechanisms of formation of historical politics and historical memory of the Napoleonic wars and the First World War.
«МЮНХЕН – 38. НА ПОРОГЕ КАТАСТРОФЫ»
Authors: Экштут С.А. 
Published: December 2024

В статье рассказывается об историко-документальной выставке, которая открылась в Выставочном зале федеральных государственных архивов. Предыстория заключения Мюнхенского соглашения 1938 года предстает под необычным ракурсом – как противостояние разведок СССР, Германии и Польши.
The article evaluates a historical documentary exhibition, which opened in the Exhibition Hall of the Federal State Archives. The preparation for the Munich Agreement of 1938 is shown under an unusual angle: as the opposition of the intelligence services of the USSR, Germany and Poland.
КРАСНОРЕЧИЕ МАКРОКОСМА И ГРАММАТИКА ВЕНЕРЫ
Authors: Иванова Ю.В. 
Published: December 2024

Рец. на кн.: Шартрская школа. Гильом Коншский. Философия. Теодорих Шартрский. Трактат о шести днях творения. Бернард Сильвестр. Космография. Астролог. Комментарий на первые шесть книг «Энеиды». Алан Лилльский. Плач Природы / Изд. подг. О.С. Воскобойников, пер. и комм.: О.С. Воскобойников, Р.Л. Шмараков, П.В. Соколов, Отв. ред. М.Ю. Реутин. М.: Наука, 2018.
This article deals with the first Russian translation of major prosimetric opera and prosaic exegetical texts originated from the so-called “school of Chartres”. A special attention is paid to the place of this edition in Russian and Western historiography of the 12th century philosophy and Medieval Latin exegesis. It has been shown that the way of selecting the texts for the translation and the method of commenting them carried out by the editors of the anthology make it possible to withdraw the Chartres school from the “no man’s land” between the history of ideas and traditional history of philosophy, restoring its appropriate status in the history of the European intellectual culture – at the intersection of theology, Platonic natural philosophy and poetry.
«СТРАННОЕ ОБАЯНИЕ ТРАГЕДИИ» Размышления о книге В.В. Тихонова «Идеологические кампании “позднего сталинизма” и советская историческая наука»
Authors: Метель О.В. 
Published: December 2024

Рецензия посвящена монографии В.В. Тихонова, в которой рассматривается влияние на историографию идеологических кампаний второй половины 1940-х – начала 1950-х гг. Рецензент делает замечания относительно структуры работы, принципов отбора и изложения материала, методологических принципов автора.
The review is devoted to a monograph by V.V. Tikhonov which considered the impact on historiography of the ideological campaigns of the second half of the 1940s – early 1950s. The reviewer comments on the structure of the work, the principles of selection and presentation of the material, the methodological principles of the author.
БИОЭТИЧЕСКОЕ ЗНАНИЕ И ПРОБЛЕМЫ БИОЭТИКИВ КОНТЕКСТЕ СОЦИОКУЛЬТУРНОЙ ДИНАМИКИ ОБЩЕСТВАКРУГЛЫЙ СТОЛ
Authors: Петрова М.С. 
Published: December 2024

В статье анализируются доклады, прочитанные и обсужденные на Круглом столе по проблемам биоэтики 2 октября 2018 г., на кафедре философии и истории медицины Первого МГМУ им. И.М. Сеченова (Сеченовский университет).
The author analyses papers presented and discussed at the Problems of Bioethics Workshop, which took place on 2 October 2018, at the department of philosophy and history of medicine of the First State Medical University (the Sechenov University).
Chitosan: Microsphere Formulation and Characterization for Slow -
Release Prebiotic Activities in Gut Microbiota Remodelling
Authors: Kumar Sunny , Bhatia Zeel , Seshadri Sriram 
Published: December 2024

Introduction:
Chitosan is a biocompatible, mucoadhesive, and biodegradable polymer
widely used for various purposes due to its biological activity and safety. The current study aimed
to formulate Chitosan microspheres and conduct an in-vitro evaluation of their cytotoxicity. The
concept is focused on targeted gut delivery and biological activities in gut microbiota remodelling.

Methods:
The formulations were comprehensively characterized, encompassing SEM for surface
morphology, particle size analysis, and FT-IR for structural understanding. Along with biological
activity and cytotoxicity studies, dissolution efficiency was considered to understand release kinetics
potential and accelerated stability studies to predict formulation shelf-life.

Results:
The formulation showed smooth spherical surface morphology with an average size
range of 30.0 ± 5.0 μm and a charge of 20.35 ± 0.35 mV. Further, functional and thermal properties
were determined using FT-IR and DSC, respectively. The microspheres showed a potent prebiotic
potential in gut flora isolated and processed from a faecal sample of Wistar rats with prolonged
release characteristics in the dissolution study. A cytotoxicity study using rat intestinal
epithelial cells (IEC6) indicated that 40 mg /kg of microspheres could be considered an optimal
dose for an in-vivo study.

Conclusion:
The formulation demonstrated promising pharmaceutical applicability due to its potential
prebiotic nature and slow release into the gut environment. After a thorough in vivo study,
the microspheres can be broadly used to restore gut dysbiosis due to their potential prebiotic activities
in various diseases and disorders, including but not limited to obesity, type-2 diabetes, cardiometabolic
disease, and non-alcoholic fatty liver disease.
The Application of Nanobubble Technology in Hydroponic SWU-01 to Increase Dissolved Oxygen Concentration and Lettuce Plant Growth
Authors: Yusuf Asep , Asdak Chay , Muhaemin Mimin , Fuadah Eza Zahrotul , Dwiratna Sophia , Alam Muhammad Achirul , Sugiarto Anto Tri , Alam Hilman Syaeful 
Published: December 2024

Hydroponic model SWU-01 is a new hydroponic system innovation that regulates watering automatically and independently by utilizing gravity and Archimedes' law. Dissolved oxygen concentration in SWU-01 is only around 3-4.2 mg/L. DO values can be increased by applying nanobubble technology. Ultrafine bubble or nanobubble is a gas bubble in a liquid that has a diameter of <200 nm. The purpose of this study was to determine the effect of nanobubble on dissolved oxygen concentration and growth of lettuce plants cultivated with SWU-01 hydroponics. The experiment used a one-factor randomized complete block design, namely intermittent administration of nanobubble for 15 min every 3 day (P1) and 7 days (P2), and without nanobubble (P0l). The results obtained based on the ANOVA test at the 5% level with the Least Significant Difference (LSD) follow-up test, namely the parameters of fresh weight and number of leaves of lettuce P1 significantly different from P0 and P2, and no significant differences were found in root length, canopy width, and plant height. The P1 treatment is more effective in increasing dissolved oxygen concentration, leaf count, and fresh weight of lettuce produced in lettuce cultivation using the SWU-01 hydroponic system. Keywords: Dissolved oxygen, Hydroponics, Lettuce, Nanobubbles, Plant growth.
Drying Characteristics of Papaya (Carica Papaya L.) Fruit Leather Using Microwave Oven
Authors: Purbasari Dian , Wicaksono Vicky Andhik , Taruna Iwan , Yosika Nur Ida Winni 
Published: December 2024

Fruit leather is a thin sheet of oven-dried fruit flesh. While papaya fruit is a perishable fruit with various types of fruit leather is one of the processed food products that can be preserved and has added value. This study aimed to determine papaya fruit leather’s drying characteristics using a microwave oven, namely changes in water content, drying rate, color, and water activity. The methods used were experimental methods with treatment variables of different microwave power (329 W, 428 W, and 701 W) and material thickness (1 mm, 3 mm, and 5 mm). The research design was selected in complete randomization with 3 replications. The results showed that the moisture content value decreased from 87.10-87.67%bb to 10.21-16.51%bb. The highest drying rate occurred at 701 W power and 1 mm material thickness with a value of 282.79%bb. The highest total color (∆E) value occurred in the treatment of 701 W power and 1 mm material thickness which was 28.78. The highest water activity (aw) value occurred at 329 W power treatment and 5 mm material thickness which was 0.463. Keywords: Drying, Fruit leather, Microwave, Papaya.
FIRST YEAR EXPERIENCE IN TOTAL ENDOSCOPIC MITRAL VALVE REPAIR WITH THREE-DIMENSIONAL VIDEO-ASSISTED TECHNOLOGY
Authors: Fiorentino M. , Mikus E. , Costantino A. , Sangiorgi D. , Tenti E. , Tremoli E. , Savini C. 
Published: December 2024

Background:
The minimally invasive approach is the gold standard for mitral valve surgery. Advancements in technology are crucial for enhancing surgical outcomes and reducing invasiveness. We present our experience with total endoscopic mitral valve repair.

Methods:
From July 2023 to June 2024, 61 patients underwent total endoscopic mitral valve repair with three-dimensional video-assisted technology (EinsteinVision® 3.0, B. Braun, Aesculap AG, Tuttlingen, Germany). Median age was 61 years (53-68) and 62.3% were males. Median EuroSCORE II was 0.76 (0.56-1.14).

Results:
The majority of patients were in NYHA class II and 42.6% had pulmonary hypertension. Seven (11.5%) patients underwent associate procedures. No conversion to full sternotomy was necessary. In six (9.84%) patients with left coronary dominance we used indocyanine green fluorescence for a real-time analysis of the course of the circumflex artery during surgery. No perioperative acute myocardial infarction or stroke was observed. No 30- day mortality was reported, while one patient (1.6%) suffered from sepsis and multi-organ failure leading to in-hospital death. Atrial fibrillation was observed in 14 patients (23%) and 1 patient (1.6%) required Pace-maker implantation. We observed 2 (3.3%) re-thoracotomies for bleeding and 41% of patients required blood transfusions. Median ventilation time was 5 hours (4-6). Median intensive care unit and in-hospital stay were 2 (2-2) and 7 (7-9) days.

Conclusions:
Total endoscopic mitral valve surgery is safe and feasible with good postoperative outcomes. Moreover, the possibility to use indocyanine green fluorescence to detect the course of the circumflex artery assist surgeons, reducing the risk of perioperative myocardial infarction.
IS THE SURGICAL OPTION TOO CHALLENGING IN CASE OF MULTIVALVULAR INFECTIVE ENDOCARDITIS?
Authors: Kushta E. , Seminari E. , Amoroso F. , Laerta S. , Sangaletti G. , De Gregori D. , Villano V. A. , Pucci F. , Pelenghi S. , Totaro P. 
Published: December 2024

Background:
Double-valve infective endocarditis (DVIE) accounts for 15–20% of all endocarditis. The mechanisms of extension of the infection differ as in left-sided DVIE, there is often a primary focus in aortic valve which then involves the mitral valve. On other hands bilateral endocarditis is often the consequence of the infection’s haematogenous spread. Therapeutical strategies and managements of DVIE are still debated being the surgical option somewhat challenging. Here we report our single center experience in managements of DVIE.

Methods and Materials:
Our Endocarditis Registry STEADY, include patients admitted with a diagnosis of IE from 2009 to 2024. Data were retrospectively analyzed focusing on DVIE. All cases were independently evaluated by an infectious disease specialist, a cardiologist and a cardiac surgeon. Variables associated with in-hospital and 1-year mortality were compared between two groups: patients with surgical treatment (STG) and patients with conservative treatment (MTG).

Results:
Out of 398 patients enrolled in STEADY, 63 (15.8%) had a diagnosis of DVIE. 51 (81%) pts had left side endocarditis, 12 (19%) bilateral endocarditis. 39 (62%) were included in STG group; 24(38%) in MTG. Out of 39 patients of the STG, 18(46%) received urgent surgery. The most frequent pathogen was Streptococcus spp. in both groups (38% in MTG and 31% in STG), followed by Staphylococcus spp. (21% and 23%). Overall 1-year mortality was 19% in STG and 46% on MTG (p=0,047).

Conclusions:
Patients with DVIE still carry high risk of poor outcomes. To improve the prognosis, patients at higher risk for complications need to be identified and an aggressive therapeutic approach could probably be beneficial.
TWO DECADES OF MITRAL VALVE REPAIR IN PATIENTS WITH SMALL CALCIFICATIONS: LONG-TERM OUTCOMES AND PROGNOSTIC FACTORS
Authors: Giambuzzi I. , Bonalumi G. , Maccarana A. , Naliato M. , Alamanni F. , Zanobini M. 
Published: December 2024

Introduction:
Mitral valve calcifications increase the complexity of valvular repair. Major calcifications have a known impact on the outcomes, while minor calcifications are less studied. We aim to define the role of minor mitral valve calcification on long term results of valvular repair.

Methods:
Retrospective study on patients who underwent mitral valve repair between 2001 and 2010. Patients who had a degenerative mitral valve disease, minor calcification at pre-operative echocardiogram confirmed at surgical inspection and no employment of decalcification techniques were included. A control group was selected using a 1:2 match using propensity score. Kaplan-Meier curves estimated long term survival and mitral valve events (recurrent mitral regurgitation>2+, mitral valve reintervention, endocarditis and cardiac death. Cox- model estimated the unadjusted and adjusted hazard ratio.

Results:
A total of 1052 patients underwent mitral valve repair and 42(3.99%) met the inclusion criteria. 76 patients were selected to form the Control Group. The only significant preoperative difference among the two groups was the presence of coronaropathy, which was more common in the group with mitral calcification (p-value 0.0283). At follow-up, 30 patients developed the study endpoint (Control Group: n=13, 17.1%; Group with mitral calcification: n=17, 40.5%; p=0.0053). The 19-year survival by Kaplan–Meier analysis showed that mitral valve calcification is associated with a worse survival (HR: 2.538 [1.520-4.238], p=0.0004), even after adjusting for preoperative coronary disease.

Conclusions:
Minor mitral calcifications are associated with a worse outcome, even after adjusting for preoperative coronary disease. Minor calcification should be taken into account when planning surgery and follow up.
FU.T.U.RE. STUDY (FUNCTIONAL TRICUSPID UPDATE STUDY ON RECURRENCE)
Authors: Mazzenga G. , Grandinetti M. , Chiariello G. A. , Nesta M. , Cammertoni F. , Calabrese M. , Testa N. , Montesano M. , Pavone N. , Bruno P. , Massetti M. 
Published: December 2024

Background and Aim:
In current clinical practice, tricuspid valve surgery is often overlooked and lacks adequate standardization. This leads to a considerable risk of tricuspid regurgitation recurrence after mitral-tricuspid surgery, significantly affecting patient outcomes. Our study investigates the predictive role of demographic, clinical, echocardiographic, and surgical factors in tricuspid regurgitation recurrence to help address this critical prognostic challenge.

Methods:
This single-center, ambispective, observational study included 178 patients who underwent mitral-tricuspid surgery at our institution between January 2012 and June 2019. Follow-up data were collected at an average of 6 years post-intervention. We conducted a univariable analysis of major demographic, clinical, echocardiographic, and surgical factors. Significant and suggestive predictors were integrated into a multivariable model, from which we developed a nomogram as a predictive tool.

Results:
Univariable analysis revealed several parameters significantly associated with an increased risk of recurrent tricuspid regurgitation. Following multivariable analysis, suture ring-less repair emerged as an independent predictor of recurrence, linked with a 3.7-fold increased recurrence risk. All factors included in the multivariable model were subsequently incorporated into a scoring system designed to predict 5-year recurrence-free survival before surgery.

Conclusions:
Our innovative scoring system’s aim is to contribute to building in the “real world” a uniform and patient-tailored perspective for functional tricuspid valve regurgitation surgery. This knowledge could help improving patient care as well as contributing to the advancement of surgical strategies in this critical area of surgery.
ENDOCARDITIS TEAM? DESIGNING AN ORIGINAL AND TAILORED CLINICAL PATHWAY
Authors: Pavone N. , Cammertoni F. , Bruno P. , Calabrese M. , Grandinetti M. , D’acierno E. M. , Cutrone G. , Lombardo A. , Scoppettuolo G. , Massetti M. 
Published: December 2024

Background and Aim:
Incidence of infective endocarditis (IE) is worryingly increasing. Clinical care of IE is often fragmented resulting in delayed diagnosis and suboptimal management. According to recent guidelines, in 2023 we created the Endocarditis Team (ET), providing the most appropriate diagnostic tests and treatment options through a dedicated clinical pathway (CP). In this study we compare clinical and management outcomes of patients treated before and after the CP.

Methods:
We prospectively collected data from surgically treated patients, at our institution, after the CP implementation (post-CP group) and compared them with data from the previous 3 years (pre- CP group). We analyzed baseline characteristics such as clinical presentation, disease complexity, in-hospital mortality and management outcomes such as ICU stay and post- operative and total in-hospital length of stay.

Results:
Fifty-six patients underwent surgery for IE during the Post-CP group (2023-2024), compared to 82 patients in the Pre-CP group (2020-2022). Clinical presentation was similar in the two groups even though patients in the Post-CP group had higher numbers of pseudoaneurysms, abscesses and redo procedures. STS-PROMM was higher in the Post-CP group (33.4 ± 7.5 vs 29.3 ± 8.7, p<0.01). No difference for in-hospital mortality was found (7.3% vs 8.9%). Length of ICU (4 vs 6 days) and post-operative in-hospital stay (30.5 vs 32 days) increased in the post-CP group. Total in-hospital stay showed a two-day reduction in the post-CP group (43 vs 41 days).

Conclusions:
Although some controversies still exist, we believe that our ET had a positive impact on healthcare of patients with IE.
MEDICAL THERAPY IN TYPE B AORTIC INTRAMURAL HEMATOMA: A VERY RECENT SINGLE-CENTER EXPERIENCE
Authors: Calanni Macchio C. , Damiano A. , Milione A. , Mileo E. , Lonardo E. , Hamameh S. H. B. , Pisapia G. , Di Tommaso L. 
Published: December 2024

Background and Aim:
Type B intramural hematoma (TBIMH) management is unclear. Recent guidelines recommend optimal medical therapy (OMT) for stable cases without high-risk signs, closely monitoring evolution with regular imaging follow-ups. OMT and elective TEVAR are suggested for high-risk patients and emergent TEVAR for complicated IMH. In this single-center retrospective series, we report our experience of OMT failure.

Methods:
From January to June 2024, 4 patients were admitted at our department diagnosed with TBIMH. All of them, without high-risk features or complications, received OMT until unexpected complications occurred, meeting criteria for endovascular repair.

Results:
One patient underwent surgical treatment after 12 days of OMT due to worsening neurological status and CT evidence of focal contrast enhancements. The remaining patients, initially discharged on medical treatment, developed Type B dissection progression with new symptoms or CT scan worsening after one month. We performed TEVAR for all of them. Post-operative period was uneventful and early follow-up outcomes are good, except for the requiring of rehabilitation for the patient with neurological complications.

Conclusions:
OMT and observation remains the treatment main-stay for patients with TBIMH. Nevertheless, delayed endovascular repair, subsequent to OMT failure, cannot solve the following complications or sequelae or even death. The question remains: is medical approach safe? Which is the ideal frequency of CT scan control? Further studies, long-term follow-up and adequate sample size may answer.
MELD AND MELD-BASED SCORE AS POTENTIAL EARLY MARKER OF VISCERAL MALPERFUSION IN PATIENTS WITH ACUTE AORTIC DISSECTION
Authors: Totaro P. , Kushta E. , Musto M. , Amoroso F. , Pelenghi S. 
Published: December 2024

Introduction:
Acute aortic dissection of the ascending aorta carries a very high early mortality up to 1%-2% /h in untreated symptomatic patients. Immediate surgical treatment, therefore, has been considered so far the gold standard in such conditions. The relevance of preoperative peripheral malperfusion in postoperative outcome, however has been recently pointed out suggesting the option for a primary stabilization of peripheral (especially visceral) malperfusion. The diagnosis of clinically significant visceral malperfusion, however, is still unclear and often underdiagnosed. Here we evaluate the potential of using MELD and MELD- based scores, as marker of significant malperfusion, in preoperative prediction of postoperative in-hospital mortality

Materials and Methods:
160 patients undergoing surgical repair of acute aortic dissection over a 10-year period with a complete preoperative blood analysis recorded in our system were retrospectively enrolled in this study. Preoperative MELD (Model for End stage Liver Disease) a simple preoperative score, calculated from 3 biochemical variable, and MELD-based scores were calculated and a potential correlation with postoperative mortality was analysed.

Results:
Overall In-hospital Mortality was 16,8%. MELD Score ranged between 3 and 26. Overall MELD score was significantly higher in patients who died postoperatively, especially in male patients. Furthermore Meld >8 was predictive risk factor for in-hospital postoperative mortality. MELD-based scores were higher in death patients without statistical significance.

Discussion:
In conclusion MELD score could represent a simple method to predict postoperative mortality in case of acute aortic syndrome, detecting early signs of visceral malperfusion, potentially amenable of an “abdomen first” treatment.