bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical safety of ProMRI implantable cardioverter-defibrillator systems during head and lower lumbar magnetic resonance imaging at 1.5 Tesla
Authors: Bauer Wolfgang Rudolf , Lau Dennis H. , Wollmann Christian , McGavigan Andrew , Mansourati Jacques , Reiter Theresa , Frömer Simone , Ladd Mark E. , Quick Harald H. 
Published: December 2019

AbstractMagnetic resonance imaging (MRI) has long been contraindicated in patients with implanted pacemakers, defibrillators, and cardiac resynchronisation therapy (CRT) devices due to the risk of adverse effects through electromagnetic interference. Since many recipients of these devices will have a lifetime indication for an MRI scan, the implantable systems should be developed as ‘MRI-conditional’ (be safe for the MRI environment under predefined conditions). We evaluated the clinical safety of several Biotronik ProMRI (‘MRI-conditional’) defibrillator and CRT systems during head and lower lumbar MRI scans at 1.5 Tesla. The study enrolled 194 patients at 22 sites in Australia, Canada, and Europe. At ≥9 weeks after device implantation, predefined, non-diagnostic, specific absorption rate (SAR)-intensive head and lower lumbar MRI scans (total ≈30 minutes per patient) were performed in 146 patients that fulfilled pre-procedure criteria. Three primary endpoints were evaluated: freedom from serious adverse device effects (SADEs) related to MRI and defibrillator/CRT (leading to death, hospitalisation, life-threatening condition, or potentially requiring implanted system revision or replacement), pacing threshold increase, and sensing amplitude decrease, all at the 1-month post-MRI clinical visit. No MRI-related SADE occurred. Lead values remained stable, measured in clinic and monitored daily by the manufacturer home monitoring technology.
X-ray magnetic linear dichroism as a probe for non-collinear magnetic state in ferrimagnetic single layer exchange bias systems
Authors: Luo Chen , Ryll Hanjo , Back Christian H. , Radu Florin 
Published: December 2019

AbstractFerrimagnetic alloys are extensively studied for their unique magnetic properties leading to possible applications in perpendicular magnetic recording, due to their deterministic ultrafast switching and heat assisted magnetic recording capabilities. On a prototype ferrimagnetic alloy we demonstrate fascinating properties that occur close to a critical temperature where the magnetization is vanishing, just as in an antiferromagnet. From the X-ray magnetic circular dichroism measurements, an anomalous ‘wing shape’ hysteresis loop is observed slightly above the compensation temperature. This bears the characteristics of an intrinsic exchange bias effect, referred to as atomic exchange bias. We further exploit the X-ray magnetic linear dichroism (XMLD) contrast for probing non-collinear states which allows us to discriminate between two main reversal mechanisms, namely perpendicular domain wall formation versus spin-flop transition. Ultimately, we analyze the elemental magnetic moments for the surface and the bulk parts, separately, which allows to identify in the phase diagram the temperature window where this effect takes place. Moreover, we suggests that this effect is a general phenomenon in ferrimagnetic thin films which may also contribute to the understanding of the mechanism behind the all optical switching effect.
Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study
Authors: Kwon Hyunwook , Kim Jee Yeon , Kim Dong Hyun , Ko Youngmin , Choi Ji Yoon , Shin Sung , Jung Joo Hee , Kim Young Hoon , Han Duck Jong ,   The Korean Organ Transplantation Registry Study Group, Ahn Curie , Chae Dong Wan , Yang Jaeseok , Choi Bum Soon , Jung Cheol Woong , Kim Myung Soo , Kwon Oh Jung , Park Jae Berm , Kim Yeong Hoon , Choi SooJinNa , Han Seung Yeup , Lee Sang Ho , Jeong Kyung Hwan , Kim Seung Jung , Jeon Jin Seok , Park Yeon Ho , Roh Young Nam , Lee Jeong Joon , Lee Kang Wook , Han Seung Yeup , Kim Chan Duck , Park Jong Won , Kim Joong Kyung , Lee Dong Ryeol , Lee Dong Won , Seong Eun Young , Kong Jin Min , Cho Hong Rae , Park Sung Kwang , Lee Sam Yeol , Park Jung Hwan 
Published: December 2019

AbstractABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive KT based on ABO incompatibility. We used data from the Korea Organ Transplantation Registry, a nationwide database, and a single-center registry. A total of 263 patients with positive XM were divided into an ABO compatible (ABOc) & XM positive (ABOc/XM+, n = 176) group and an ABOi & XM positive (ABOi/XM+, n = 87) group. The overall rejection rate one year after KT was significantly higher in the ABOi/XM+ group than in the ABOc/XM+ group (P < 0.01). A total of four mortalities occurred, all in the ABOi/XM+ patients (P < 0.01). There were no differences in surgical complications or the occurrence of infection-related complications, including BK virus nephropathy. Multivariate analysis indicated that female vs. male (odds ratio (OR), 2.27; P = 0.03), DSA class I (MFI/1000) (OR, 1.10; P = 0.03), DSA class II (MFI/1000) (OR, 1.10; P < 0.01), and ABOi & XM+ status (OR, 2.38; P < 0.01) were significant risk factors for acute rejection during the year after transplantation. Overall graft survival was inferior in ABOi/XM+ patients than in ABOc/XM+ patients (P = 0.02). ABO incompatibility in XM-positive KT patients was found to be a significant risk factor for the development of rejection within one year after transplantation as well as for long-term graft survival. The anti-blood group A, B and anti-HLA antibodies may show synergistic activity.
Mn oxide formation by phototrophs: Spatial and temporal patterns, with evidence of an enzymatic superoxide-mediated pathway
Authors: Chaput Dominique L. , Fowler Alexandré J. , Seo Onyou , Duhn Kelly , Hansel Colleen M. , Santelli Cara M. 
Published: December 2019

AbstractManganese (Mn) oxide minerals influence the availability of organic carbon, nutrients and metals in the environment. Oxidation of Mn(II) to Mn(III/IV) oxides is largely promoted by the direct and indirect activity of microorganisms. Studies of biogenic Mn(II) oxidation have focused on bacteria and fungi, with phototrophic organisms (phototrophs) being generally overlooked. Here, we isolated phototrophs from Mn removal beds in Pennsylvania, USA, including fourteen Chlorophyta (green algae), three Bacillariophyta (diatoms) and one cyanobacterium, all of which consistently formed Mn(III/IV) oxides. Isolates produced cell-specific oxides (coating some cells but not others), diffuse biofilm oxides, and internal diatom-specific Mn-rich nodules. Phototrophic Mn(II) oxidation had been previously attributed to abiotic oxidation mediated by photosynthesis-driven pH increases, but we found a decoupling of Mn oxide formation and pH alteration in several cases. Furthermore, cell-free filtrates of some isolates produced Mn oxides at specific time points, but this activity was not induced by Mn(II). Manganese oxide formation in cell-free filtrates occurred via reaction with the oxygen radical superoxide produced by soluble extracellular proteins. Given the known widespread ability of phototrophs to produce superoxide, the contribution of phototrophs to Mn(II) oxidation in the environment may be greater and more nuanced than previously thought.
Simulated evolution assembles more realistic food webs with more functionally similar species than invasion
Authors: Romanuk Tamara N. , Binzer Amrei , Loeuille Nicolas , Carscallen W. Mather A. , Martinez Neo D. 
Published: December 2019

AbstractWhile natural communities are assembled by both ecological and evolutionary processes, ecological assembly processes have been studied much more and are rarely compared with evolutionary assembly processes. We address these disparities here by comparing community food webs assembled by simulating introductions of species from regional pools of species and from speciation events. Compared to introductions of trophically dissimilar species assumed to be more typical of invasions, introducing species trophically similar to native species assumed to be more typical of sympatric or parapatric speciation events caused fewer extinctions and assembled more empirically realistic networks by introducing more persistent species with higher trophic generality, vulnerability, and enduring similarity to native species. Such events also increased niche overlap and the persistence of both native and introduced species. Contrary to much competition theory, these findings suggest that evolutionary and other processes that more tightly pack ecological niches contribute more to ecosystem structure and function than previously thought.
How water-mediated hydrogen bonds affect chlorophyll a/b selectivity in Water-Soluble Chlorophyll Protein
Authors: Agostini Alessandro , Meneghin Elena , Gewehr Lucas , Pedron Danilo , Palm Daniel M. , Carbonera Donatella , Paulsen Harald , Jaenicke Elmar , Collini Elisabetta 
Published: December 2019

AbstractThe Water-Soluble Chlorophyll Protein (WSCP) of Brassicaceae is a remarkably stable tetrapyrrole-binding protein that, by virtue of its simple design, is an exceptional model to investigate the interactions taking place between pigments and their protein scaffold and how they affect the photophysical properties and the functionality of the complexes. We investigated variants of WSCP from Lepidium virginicum (Lv) and Brassica oleracea (Bo), reconstituted with Chlorophyll (Chl) b, to determine the mechanisms by which the different Chl binding sites control their Chl a/b specificities. A combined Raman and crystallographic investigation has been employed, aimed to characterize in detail the hydrogen-bond network involving the formyl group of Chl b. The study revealed a variable degree of conformational freedom of the hydrogen bond networks among the WSCP variants, and an unexpected mixed presence of hydrogen-bonded and not hydrogen-bonded Chls b in the case of the L91P mutant of Lv WSCP. These findings helped to refine the description of the mechanisms underlying the different Chl a/b specificities of WSCP versions, highlighting the importance of the structural rigidity of the Chl binding site in the vicinity of the Chl b formyl group in granting a strong selectivity to binding sites.
Alterations in heart-brain interactions under mild stress during a cognitive task are reflected in entropy of heart rate dynamics
Authors: Blons Estelle , Arsac Laurent M. , Gilfriche Pierre , McLeod Heather , Lespinet-Najib Veronique , Grivel Eric , Deschodt-Arsac Veronique 
Published: December 2019

AbstractMany people experience mild stress in modern society which raises the need for an improved understanding of psychophysiological responses to stressors. Heart rate variability (HRV) may be associated with a flexible network of intricate neural structures which are dynamically organized to cope with diverse challenges. HRV was obtained in thirty-three healthy participants performing a cognitive task both with and without added stressors. Markers of neural autonomic control and neurovisceral complexity (entropy) were computed from HRV time series. Based on individual anxiety responses to the experimental stressors, two subgroups were identified: anxiety responders and non-responders. While both vagal and entropy markers rose during the cognitive task alone in both subgroups, only entropy decreased when stressors were added and exclusively in anxiety responders. We conclude that entropy may be a promising marker of cognitive tasks and acute mild stress. It brings out a new central question: why is entropy the only marker affected by mild stress? Based on the neurovisceral integration model, we hypothesized that neurophysiological complexity may be altered by mild stress, which is reflected in entropy of the cardiac output signal. The putative role of the amygdala during mild stress, in modulating the complexity of a coordinated neural network linking brain to heart, is discussed.
A Non-electric and Affordable Surface Engineered Particle (SEP) based Point-of-Use (POU) Water Disinfection System
Authors: Dixit Deepa , Soppina Virupakshi , Ghoroi Chinmay 
Published: December 2019

AbstractAccess to safe drinking water is still a distant dream to millions of people around the world. Especially, people from the low-income group in the developing countries remain deprived of this fundamental right and causes millions of death. There is an urgent need to develop affordable and easy to handle water filter which can provide desired drinking water quality without any electricity. In the present work, a simple and low-cost surface engineered particle (SEP) based filter is developed via alkali treatment of soda-lime-silica particle. The SEP based filter can be used as a portable, non-electric, gravity-driven Point-of-Use (POU) water disinfection system. The developed SEP-based filter is capable to arrest the 99.48% (~2 to 2.5 log10 reduction) of gram-negative bacteria Escherichia coli (E. coli OP50) on its surface from the water containing 3 × 108 cells/ml. No bacterial regrowth is observed in the purified water for 12 h. The performance of SEP bed filter is implicated to the nano-scale surface roughness, its distribution along with the surface charge and surface hydrophobicity which are favorable to attract and adhere the bacteria in the flowing water. The observation is consistent over multiple filtration cycles indicating the suitability of SEP based bed filter for POU water disinfection. The SEP surface with 0.05 mM Ag+ loading (SEP+) completely inactivated (>99.99999%) bacteria and protects any bacteria recontamination in the purified water for its long term usage. The strong and effective silver binding property of SEP surface enables very minimal silver loading and eliminates any health hazard due to low silver leaching (~50 ppb) which is well below the drinking water equivalent level (DWEL ≤ 100 ppb). In rural and urban slum areas of developing countries where no water purification system exists prior to consumption, the easy-to-implement and affordable SEP-based gravity-driven non-electric point-of-use water purifier (materials cost ~ 0.25 USD) can be used to protect millions of lives from water borne diseases.
Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation
Authors: Vallance Thomas M. , Ravishankar Divyashree , Albadawi Dina A. I. , Layfield Harry , Sheard Jonathan , Vaiyapuri Rajendran , Dash Philip , Patel Ketan , Widera Darius , Vaiyapuri Sakthivel 
Published: December 2019

AbstractPlatelets are small circulating blood cells that play essential roles in the maintenance of haemostasis via blood clotting. However, they also play critical roles in the regulation of innate immune responses. Inflammatory receptors, specifically Toll-like receptor (TLR)-4, have been reported to modify platelet reactivity. A plethora of studies have reported controversial functions of TLR4 in the modulation of platelet function using various chemotypes and preparations of its ligand, lipopolysaccharide (LPS). The method of preparation of LPS may explain these discrepancies however this is not fully understood. Hence, to determine the impact of LPS on platelet activation, we used ultrapure preparations of LPS fromEscherichia coli(LPSEC),Salmonella minnesota(LPSSM), andRhodobacter sphaeroides(LPSRS) and examined their actions under diverse experimental conditions in human platelets. LPSECdid not affect platelet activation markers such as inside-out signalling to integrin αIIbβ3or P-selectin exposure upon agonist-induced activation in platelet-rich plasma or whole blood whereas LPSSMand LPSRSinhibited platelet activation under specific conditions at supraphysiological concentrations. Overall, our data demonstrate that platelet activation is not largely influenced by any of the ultrapure LPS chemotypes used in this study on their own except under certain conditions.
Expanding the parameter space of anodal transcranial direct current stimulation of the primary motor cortex
Authors: Agboada Desmond , Mosayebi Samani Mohsen , Jamil Asif , Kuo Min-Fang , Nitsche Michael A. 
Published: December 2019

AbstractSize and duration of the neuroplastic effects of tDCS depend on stimulation parameters, including stimulation duration and intensity of current. The impact of stimulation parameters on physiological effects is partially non-linear. To improve the utility of this intervention, it is critical to gather information about the impact of stimulation duration and intensity on neuroplasticity, while expanding the parameter space to improve efficacy. Anodal tDCS of 1–3 mA current intensity was applied for 15–30 minutes to study motor cortex plasticity. Sixteen healthy right-handed non-smoking volunteers participated in 10 sessions (intensity-duration pairs) of stimulation in a randomized cross-over design. Transcranial magnetic stimulation (TMS)-induced motor-evoked potentials (MEP) were recorded as outcome measures of tDCS effects until next evening after tDCS. All active stimulation conditions enhanced motor cortex excitability within the first 2 hours after stimulation. We observed no significant differences between the three stimulation intensities and durations on cortical excitability. A trend for larger cortical excitability enhancements was however observed for higher current intensities (1 vs 3 mA). These results add information about intensified tDCS protocols and suggest that the impact of anodal tDCS on neuroplasticity is relatively robust with respect to gradual alterations of stimulation intensity, and duration.
Physiological performance of glyphosate and imazamox mixtures on Amaranthus palmeri sensitive and resistant to glyphosate
Authors: Fernández-Escalada Manuel , Zulet-González Ainhoa , Gil-Monreal Miriam , Royuela Mercedes , Zabalza Ana 
Published: December 2019

AbstractThe herbicides glyphosate and imazamox inhibit the biosynthetic pathway of aromatic amino acids (AAA) and branched-chain amino acids (BCAA), respectively. Both herbicides share several physiological effects in the processes triggered in plants after herbicide application that kills the plant, and mixtures of both herbicides are being used. The aim of this study was to evaluate the physiological effects in the mixture of glyphosate and imazamox in glyphosate-sensitive (GS) and -resistant (GR) populations of the troublesome weed Amaranthus palmeri. The changes detected in the physiological parameters after herbicide mixtures application were similar and even less to the changes detected after individual treatments. This pattern was detected in shikimate, amino acid and carbohydrate content, and it was independent of the EPSPS copy number, as it was detected in both populations. In the case of the transcriptional pattern of the AAA pathway after glyphosate, interesting and contrary interactions with imazamox treatment were detected for both populations; enhancement of the effect in the GS population and alleviation in the GR population. At the transcriptional level, no cross regulation between AAA and BCAA inhibitors was confirmed. This study suggests that mixtures are equally or less toxic than herbicides alone, and would implicate careful considerations when applying the herbicide mixtures.
Analysis of proliferating neuronal progenitors and immature neurons in the human hippocampus surgically removed from control and epileptic patients
Authors: Seki Tatsunori , Hori Tomokatsu , Miyata Hajime , Maehara Michiyo , Namba Takashi 
Published: December 2019

AbstractAdult neurogenesis in the mammalian hippocampus is a well-known phenomenon. However, it remains controversial as to what extent adult neurogenesis actually occurs in the adult human hippocampus, and how brain diseases, such as epilepsy, affect human adult neurogenesis. To address these questions, we analyzed immature neuronal marker-expressing (PSA-NCAM+) cells and proliferating neuronal progenitor (Ki67+/HuB+/DCX+) cells in the surgically removed hippocampus of epileptic patients. In control patients, a substantial number of PSA-NCAM+ cells were distributed densely below the granule cell layer. In epileptic patients with granule cell dispersion, the number of PSA-NCAM+ cells was reduced, and aberrant PSA-NCAM+ cells were found. However, the numbers of Ki67+/HuB+/DCX+ cells were very low in both control and epileptic patients. The large number of PSA-NCAM+ cells and few DCX+/HuB+/Ki-67+ cells observed in the controls suggest that immature-type neurons are not recently generated neurons, and that the level of hippocampal neuronal production in adult humans is low. These results also suggest that PSA-NCAM is a useful marker for analyzing the pathology of epilepsy, but different interpretations of the immunohistochemical results between humans and rodents are required.
The modulation of event-related alpha rhythm during the time course of anticipation
Authors: Simonet Marie , Meziane Hadj Boumediene , Runswick Oliver Richard , North Jamie Stephen , Williams Andrew Mark , Barral Jérôme , Roca André 
Published: December 2019

AbstractAnticipation is the ability to accurately predict future actions or events ahead of the act itself. When attempting to anticipate, researchers have identified that at least two broad sources of information are used: contextual information relating to the situation in question; and biological motion from postural cues. However, the neural correlates associated with the processing of these different sources of information across groups varying in expertise has yet to be examined empirically. We compared anticipation performance and electrophysiological activity in groups of expert (n = 12) and novice (n = 15) performers using a video-based task. Participants made anticipation judgements after being presented information under three conditions: contextual information only; kinematic information only; and both sources of information combined. The experts responded more accurately across all three conditions. Stronger alpha event-related desynchronization over occipital and frontocentral sites occurred in experts compared to the novices when anticipating. The experts relied on stronger preparatory attentional mechanisms when they processed contextual information. When kinematic information was available, the domain specific motor representations built up over many years of practice likely underpinned expertise. Our findings have implications for those interested in identifying and subsequently, enhancing the neural mechanisms involved in anticipation.