bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications
Authors: Scaldaferri Franco , Ianiro Gianluca , Privitera Giuseppe , Lopetuso Loris Riccardo , Vetrone Lorenzo Maria , Petito Valentina , Pugliese Daniela , Neri Matteo , Cammarota Giovanni , Ringel Yehuda , Costamagna Guido , Gasbarrini Antonio , Boskoski Ivo , Armuzzi Alessandro 
Published: July 2020

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a direct impact on the gastrointestinal system, as up to 50% of fecal samples from coronavirus disease 2019 (COVID-19) patients contain detectable viral RNA despite a negative rhino-pharyngeal swab. This finding, together with an intestinal expression of angiotensin conversion enzyme 2 protein, suggests a possible fecal-oral transmission for SARS-CoV-2. Furthermore, gastrointestinal (GI) symptoms are common in COVID-19 patients including watery diarrhea, vomiting—particularly in children—nausea, and abdominal pain.Pathogenesis of SARS-CoV-2 infection presents significant similarities to those of some immune-mediated diseases, such as inflammatory bowel diseases or rheumatoid arthritis, leading to the hypothesis that targeted therapies used for the treatment of immune-mediated disease could be effective to treat (and possibly prevent) the main complications of COVID-19.In this review, we synthesize the present and future impact of SARS-CoV-2 infection on the gastrointestinal system and on gastroenterology practice, hypothesizing a potential role of the “gut-lung axis” and perhaps of the gut and lung microbiota into the interindividual differential susceptibility to COVID-19 19 disease.Finally, we speculate on the reorganization of outpatient gastroenterology services, which need to consider, among other factors, the major psychological impact of strict lockdown measures on the whole population.
Detecting fracture zones in granite with seismic and audio-magnetotelluric methods
Authors: Yao Shancong , Wang Wei , Wang Ju , Su Rui , Gao Xing , Zhang Ruliang , Duan Shuxin , Chen Shuang 
Published: July 2020

Abstract
Geological disposal is a feasible and safe method for dealing with the high-level radioactive waste problem at present. The Beishan area is the key area preselected for high-level radioactive waste geological disposal in Gansu Province, China. The Jijicao rock block is currently the most extensively studied area, where there are several fracture zones in borehole BS15. In 2011, a remarkable conductive anomaly near the BS15 was detected using a 4-km-long audio-magnetotelluric (AMT) profile with 50 m station space crossing the borehole. To study the anomaly, a short seismic survey was shot along the part of the AMT profile. This paper presents an example for detection of the fracture zones in granite using AMT and seismic methods at Beishan. The AMT data inversion model agrees with the borehole well-logging data and weak reflections are related to the fractured zones. The seismic detection may help in interpreting the cause of the conductive anomaly, and the conductive anomaly could determine whether there are fracture zones within the weak reflection areas. The simultaneous surveys can complement each other for detecting fracture zones. Besides this, such joint detection may be used to estimate whether there exist aquiferous fracture zones at depth.
Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic
Authors: D′Agostino Armando , D’Angelo Simone , Giordano Barbara , Cigognini Anna Chiara , Chirico Margherita Lorenza , Redaelli Cristiana , Gambini Orsola 
Published: July 2020

Abstract
The impact of the COVID-19 pandemic on psychosis remains to be established. Here we report 6 cases (3 male and 3 female) of first-episode psychosis (FEP) admitted to our hospital in the second month of national lockdown. All patients underwent routine laboratory tests and a standardized assessment of psychopathology. Hospitalization was required due to the severity of behavioral abnormalities in the context of a full-blown psychosis (the Brief Psychiatric Rating Scale [BPRS] = 75.8 ± 14.6). Blood tests, toxicological urine screening, and brain imaging were unremarkable, with the exception of a mild cortical atrophy in the eldest patient (male, 73 years). All patients were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout their stay, but 3 presented the somatic delusion of being infected. Of note, all 6 cases had religious/spiritual delusions and hallucinatory contents. Despite a generally advanced age (53.3 ± 15.6), all patients had a negative psychiatric history. Rapid discharge (length of stay = 13.8 ± 6.9) with remission of symptoms (BPRS = 27.5 ± 3.1) and satisfactory insight were possible after relatively low-dose antipsychotic treatment (Olanzapine-equivalents = 10.1 ± 5.1 mg). Brief psychotic disorder/acute and transient psychotic disorder diagnoses were confirmed during follow-up visits in all 6 cases. The youngest patient (female, 23 years) also satisfied the available criteria for brief limited intermittent psychotic symptoms. Although research on larger populations is necessary, our preliminary observation suggests that intense psychosocial stress associated with a novel, potentially fatal disease and national lockdown restrictions might be a trigger for FEP.
Molecular Diversity and Pathogenicity of Ralstonia solanacearum Species Complex Associated With Bacterial Wilt of Potato in Rwanda
Authors: Sharma Kalpana , Kreuze Jan , Abdurahman Abdulwahab , Parker Monica , Nduwayezu Anastase , Rukundo Placide 
Published: July 2020

Bacterial wilt (BW), caused by Ralstonia solanacearum species complex (RSSC), leads to substantial potato yield losses in Rwanda. Studies were conducted to (i) determine the molecular diversity of RSSC strains associated with BW of potato, (ii) generate an RSSC distribution map for epidemiological inferences, and (iii) test the pathogenicity of predominant RSSC phylotypes on six commercial potato cultivars. In surveys conducted in 2018 and 2019, tubers from wilting potato plants were collected for pathogen isolation. DNA was extracted from 95 presumptive RSSC strain colonies. The pathogen was phylotyped by multiplex PCR and typed at sequevar level. Phylotype II sequevar 1 strains were then haplotyped using multilocus tandem repeat sequence typing (TRST) schemes. Pathogenicity of one phylotype II strain and two phylotype III strains were tested on cultivars Kinigi, Kirundo, Victoria, Kazeneza, Twihaze, and Cruza. Two RSSC phylotypes were identified, phylotype II (95.79%, n = 91) and phylotype III (4.21%, n = 4). This is the first report of phylotype III strains from Rwanda. Phylotype II strains were identified as sequevar 1 and distributed across potato growing regions in the country. The TRST scheme identified 14 TRST haplotypes within the phylotype II sequevar 1 strains with moderate diversity index (HGDI = 0.55). Mapping of TRST haplotypes revealed that a single TRST ‘8-5-12-7-5’ haplotype plays an important epidemiological role in BW of potato in Rwanda. None of the cultivars had complete resistance to the tested phylotypes; the level of susceptibility varied among cultivars. Cultivar Cruza, which is less susceptible to phylotype II and III strains, is recommended when planting potatoes in the fields with history of BW. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Adoption of Innovation in Herpes Simplex Virus Keratitis
Authors: Chodosh James , Ung Lawson 
Published: July 2020

Abstract:
Herpes simplex keratitis, caused primarily by human herpes simplex virus type 1 (HSV-1), remains the most common infectious cause of unilateral blindness and vision impairment in the industrialized world. Major advances in the care of HSV keratitis have been driven in large part by the landmark Herpetic Eye Disease Study randomized clinical trials, which were among the first in ophthalmology to reflect emerging trial conventions, including multicenter subject enrollment, double-masking, placebo controls, and a priori sample size determinations. The results of these trials now form much of the evidence basis for the management of this disease. However, management patterns in clinical practice often deviate from evidence-based care. These perceived quality gaps have given rise to the evolving field of implementation science, which is concerned with the methods of promoting the application of evidence-based medicine within routine care. To overcome variations in the quality and consistency of care for HSV keratitis, a range of clinical- and technology-based innovations are proposed. The most pressing needs include the following: a rational and tractable disease classification scheme that provides an immediate link between the anatomical localization of disease (corneal epithelial, stromal, or endothelial) and the appropriate treatment, and the actualization of an electronic medical record system capable of providing evidence-based treatment algorithms at relevant points of care. The latter would also input data to population-wide disease registries to identify implementation-rich targets for quality improvement, education, and research. These innovations may allow us to reduce the human and economic burdens of this highly morbid, and often blinding, disease.
Scheimpflug Corneal Densitometry Changes After Trabeculectomy
Authors: Pillunat Karin R. , Orphal Johanna , Haase Maike , Pillunat Lutz E. , Herber Robert 
Published: July 2020

Purpose:
To study the possible changes in Scheimpflug corneal densitometry 6 months after mitomycin C–augmented trabeculectomy and to compare these measurements with healthy controls.

Methods:
Corneal densitometry was monitored with the Pentacam HR3 before and 6 months after first-time uncomplicated mitomycin C–augmented trabeculectomy in 42 eyes of 42 white patients with open-angle glaucoma and in 22 healthy age-matched controls. Preoperative intraocular pressure (IOP), central corneal thickness, known duration of the disease, gender, the type and number of substances, applications and amount of benzalkonium chloride per day, and postoperative topical cortisone use were tested for possible correlations in the trabeculectomy group.

Results:
There was a statistically significant reduction of mean diurnal IOP from 19.0 ± 7.7 to 11.1 ± 7.7 mm Hg (P = 0.003) and the amount of pressure-lowering substances from 3.7 ± 1.0 to 0.1 ± 0.5 (P < 0.001). Densitometry measurements decreased in the entire cornea from 25.5 ± 5.7 to 23.1 ± 5.8 grayscale units (P = 0.001) with emphasis in the anterior layer. They returned close to normal 6 months after trabeculectomy and were not statistically significantly different compared with a healthy control group (22.8 ± 3.4 grayscale unit; P = 0.824). No correlations could be found with these observations and possible causing factors studied.

Conclusions:
Corneal densitometry, an objective and sensitive measure of corneal transparency, returned close to normal 6 months after trabeculectomy. Although the observations cannot be associated with any causing factor in this study, the significant IOP reduction and the nearly complete cessation of topical antiglaucomatous substances including benzalkonium chloride seem to be the most plausible reasons for this finding.
Connecting Classrooms, Clinicians, and Community Clinics Through Technology (C4Tech) for Active and Collaborative Learning
Authors: McDonald Paige L. , Straker Howard O. , Weaver Gregory C. 
Published: July 2020

Purpose
This pilot study investigated the level of cognition that physician assistant (PA) students achieved through adoption of an innovative blended learning model that connects the classroom, clinicians, and community clinics through electronic-learning (e-learning) technologies (C4Tech) used in a PA course. This education intervention aimed to facilitate authentic learning collaborations between PA students and practicing clinicians that would result in higher-order cognition related to the manifestations of social determinants of health and health disparities.

Methods
A case study approach was adopted to assess levels of cognition and changes in those levels resulting from application of an innovative blended learning model. Content analysis using Bloom's taxonomy of cognitive domains facilitated determination levels of cognition and changes in those levels. The sample of 8 groups comprised 70 PA students and 8 clinical instructors from community clinics with underrepresented patient populations.

Results
Analysis of 2 course assignments revealed that application of the C4Tech model yields high levels of cognition. By the course's end, all 8 groups achieved at least the “evaluate” level of cognition and half of the groups achieved the highest level of cognition, the “create” level. A wide variation in the level of cognition was demonstrated between the first and second assignments in each group and among groups.

Conclusion
Our findings suggest that e-learning technologies can be effective in blending classrooms and work environments for authentic and collaborative learning. Adoption of the C4Tech model yielded higher-order cognition related to course content.
The rebirth of the contact pathway: a new therapeutic target
Authors: Srivastava Priyanka , Gailani David 
Published: July 2020

Purpose of review
Anticoagulation with vitamin-K antagonists or direct oral anticoagulants is associated with a significant risk of bleeding. There is a major effort underway to develop antithrombotic drugs that have a smaller impact on hemostasis. The plasma contact proteins factor XI (FXI) and factor XII (FXII) have drawn considerable interest because they contribute to thrombosis but have limited roles in hemostasis. Here, we discuss results of preclinical and clinical trials supporting the hypothesis that the contact system contributes to thromboembolic disease.

Recent findings
Numerous compounds targeting FXI or FXII have shown antithrombotic properties in preclinical studies. In phase 2 studies, drugs-targeting FXI or its protease form FXIa compared favorably with standard care for venous thrombosis prophylaxis in patients undergoing knee replacement. While less work has been done with FXII inhibitors, they may be particularly useful for limiting thrombosis in situations where blood comes into contact with artificial surfaces of medical devices.

Summary
Inhibitors of contact activation, and particularly of FXI, are showing promise for prevention of thromboembolic disease. Larger studies are required to establish their efficacy, and to establish that they are safer than current therapy from a bleeding standpoint.
Toward International Harmonization of Breast Implant Registries: International Collaboration of Breast Registry Activities Global Common Data Set
Authors: Spronk Pauline E. R. , Begum Husna , Vishwanath Swarna , Crosbie Andy , Earnest Arul , Elder Elisabeth , Lumenta David B. , Marinac-Dabic Danica , Moore Colin C. M. , Mureau Marc A. M. , Perks Graeme , Pusic Andrea L. , Stark Birgit , von Fritschen Uwe , Klein Howard , Cooter Rodney D. , Rakhorst Hinne A. , Hopper Ingrid 
Published: July 2020

Background:
The Poly Implant Prothèse incident and breast implant-associated anaplastic large cell lymphoma have pointed to the need for uniform registries for breast implants as key features to monitoring the outcomes of breast implant surgeries internationally. The purpose of this study was to identify and harmonize common data elements collected by breast implant registries across the International Collaboration of Breast Registry Activities (ICOBRA) global consortium.

Methods:
The authors convened an international group of surgeons, consumers, nurses, registry experts, and regulators to review the data points. A modified Delphi approach was applied, to rate the importance of each point on a six-point Likert scale.

Results:
Data points from six national breast implant registries were divided into categories: clinical, implant-related, patient-reported findings; operation details and implanting technique details; patient characteristics; unique device identifiers; unique patient identifiers; and clinical demographics. A total of 52 data points collected by over 33 percent of national registries were identified. After five rounds, 34 data points formed the final set with agreed definitions. The group recognized the critical importance of additional elements that are currently not uniformly collected (e.g., patient-reported outcomes and long-term data) and set out the process for the dynamic global set updates driven by evidence gaps.

Conclusions:
The authors defined internationally agreed on common data elements and definitions used in breast implant registries. This collaboration will allow data sets to be combined, enabling an effective global early warning system of implant-related problems and further work on data sets.
The Efficacy of Surgical Treatment for Headaches in Patients with Prior Head or Neck Trauma
Authors: Amador Ricardo O. , Gfrerer Lisa , Hansdorfer Marek A. , Tsui Jane M. , Nealon Kassandra P. , Austen William G. 
Published: July 2020

Background:
Patients undergoing trigger-site deactivation surgery for headaches report a high prevalence (approximately 37 percent) of prior head or neck injury. Traditional medical treatment often fails to treat these posttraumatic patients. It is unclear whether surgery mirrors these poor outcomes. This study aims to describe the characteristics of posttraumatic headache surgery patients and compare their postoperative results to those of patients without a history of head or neck injury.

Methods:
One hundred forty-two patients undergoing trigger-site deactivation surgery were prospectively enrolled. Patients were requested to complete a preoperative questionnaire on headache history, including the Migraine Headache Index and information on prior head or neck injury. Follow-up surveys were requested at approximately 12 months postoperatively.

Results:
Seventy patients (49 percent) reported a history of head or neck injury, and 41 (29 percent) classified the injury as the precipitating event leading to their headache onset. Patients with a precipitating event were significantly less likely to report a family history of migraine. There was no significant difference in mean preoperative Migraine Headache Index between cohorts. At 12 months postoperatively, there was no significant difference in Migraine Headache Index reduction between groups. The proportion of patients who experienced at least a 50 and 80 percent improvement in Migraine Headache Index per group, respectively, was 83 and 67 percent (atraumatic), 76 and 68 percent (posttraumatic), and 71 and 63 percent (precipitating event).

Conclusions:
This study suggests that surgical outcomes in posttraumatic headache patients are comparable to those without injury. Trigger-site deactivation surgery candidates with a history of injury can therefore expect similar outcomes as reported for patients overall.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, II.
A Human Rights Perspective on Palliative Care
Authors: Mukherjea Arnab , Ali Shabana , Smith Jason A. 
Published: July 2020

Purpose:
Palliative care is regarded as fundamental to human dignity and falls under the definition of basic human rights. One considerable community of color whose needs are poorly understood consists of Asian Americans, including distinct priorities, expectations, and decision-making processes by diverse subgroups. The purpose of this work was to understand whether and to what extent unique considerations are understood among Asian American subgroups.

Method:
A scoping review was conducted among major scientific and academic databases. Broad search terms surrounding end-of-life care were combined with individual racial and ethnic identifiers encompassing Asian American subgroups.

Results:
Twenty-two articles met inclusion criteria and reflected diverse arrays of worldviews surrounding access to, utilization of, and desired outcomes from palliative care. Most articles focused on social orientations prioritizing family in disease disclosure and avenues of interventions sought with distinct patterns among subgroups.

Discussion/Conclusion:
A human rights framework emphasizing palliative and other end-of-life approaches to care may be inadequate to address unique considerations among diverse Asian American subgroups. Theorists and practitioners should incorporate practices of collectivist orientations and family contexts commonly found among these diverse communities.
Estimating Variation of Covid-19 ‘infection’ in the Population: Results from Understanding Society’s (UKHLS) first monthly covid-19 survey
Authors: Breen Richard , Ermisch John 
Published: July 2020

AbstractThe analysis in this paper uses the new Understanding Society COVID-19 survey. The key advantage of these data is that they allow us to examine infection rates for people with particular characteristics. We study how reported symptoms vary in the population and relate reported symptoms to a positive Covid-19 test in the small sample in the survey who were tested. Combining these probabilities we find that the chances of infection increase with a person’s education level, are lower and declining with age among those aged over 55, and were higher in the West Midlands and London and lower in the North East than in the rest of the country, and tended to increase with regional population density. There is also evidence that the infection rate was lower among those of a Caribbean origin. A suitably cautious estimate of the mean infection rate is that, during the period up to the end of April 2020, it was between 2% and 8%, with a central rate of about 5%.
The Mouse Action Recognition System (MARS): a software pipeline for automated analysis of social behaviors in mice
Authors: Segalin Cristina , Williams Jalani , Karigo Tomomi , Hui May , Zelikowsky Moriel , Sun Jennifer J. , Perona Pietro , Anderson David J. , Kennedy Ann 
Published: July 2020

AbstractThe study of naturalistic social behavior requires quantification of animals’ interactions. This is generally done through manual annotation—a highly time consuming and tedious process. Recent advances in computer vision enable tracking the pose (posture) of freely-behaving animals. However, automatically and accurately classifying complex social behaviors remains technically challenging. We introduce the Mouse Action Recognition System (MARS), an automated pipeline for pose estimation and behavior quantification in pairs of freely interacting mice. We compare MARS’s annotations to human annotations and find that MARS’s pose estimation and behavior classification achieve human-level performance. We also release the pose and annotation datasets used to train MARS, to serve as community benchmarks and resources. Finally, we introduce the Behavior Ensemble and Neural Trajectory Observatory (BENTO), a graphical user interface for analysis of multimodal neuroscience datasets. Together, MARS and BENTO provide an end-to-end pipeline for behavior data extraction and analysis, in a package that is user-friendly and easily modifiable.