bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysaccharide Peptide (PSP) Extract from Coriolus Versicolor Decreased Tmax of Tamoxifen and Maintained Biochemical Serum Parameters, with No Change in the Metabolism of Tamoxifen in the Rat
Authors: Naumovski Valentina , Kimble Benjamin , Laurenti Daunia , Nammi Srinivas , Norimoto Hisayoshi , Chan Kelvin 
Published: October 2020

Abstract
BackgroundNatural products such as mushrooms are increasingly used as adjunct therapies in cancer to stimulate the immune system. However, little is known about their interaction with chemotherapy drugs. This study investigated whether a commercial polysaccharide peptide (PSP) extract of the mushroom Coriolus (C.) versicolor interacts with tamoxifen, a common chemotherapy drug used in breast cancer. MethodsThe pharmacokinetic and biochemical parameters of tamoxifen in female Sprague-Dawley rats’ serum were determined after orally administering tamoxifen (20 mg/kg) at a single dose and repeated dosing with and without C. versicolor (340 mg/kg). ResultsAlthough the area-under-curve and maximum concentration showed no significant differences in both the single dose and repeated dosing, time to reach maximum concentration (Tmax) increased by 228% and 93%, respectively, in the rats treated with C. versicolor (p<0.05). The repeated dosing of C. versicolor, when co-administered with repeated dosing of tamoxifen, maintained 19 out of 23 biochemical serum parameters in rats compared to control (p<0.05). Using hepatic female rat microsomes, an in vitro study showed that the extract (10 – 100 µg/mL) did not significantly alter the rate of tamoxifen depletion which is known to be mediated by cytochromes P450 (CYP450). ConclusionsThese results indicate that C. versicolor may delay the intestinal absorption of tamoxifen and maintain biochemical serum parameters, without any change in tamoxifen’s metabolism. If clinical trials confirm this result, the timing of tamoxifen and C. versicolor administration would need to be considered to avoid potential drug interactions resulting from a delay in achieving the systemic level of the anti-cancer medication.
Synergistic activity of colistin combined with PFK-158 against colistin-resistant and colistin-susceptible Gram-negative bacteria
Authors: Chen Liqiong , Yu Kaihang , Chen Lijiang , Zheng Xiangkuo , Huang Na , Lin Yishuai , Jia Huaiyu , Liao Wenli , Cao Jianming , Zhou Tieli 
Published: October 2020

Abstract
Background: The emergence of colistin resistance among Gram-negative bacteria poses a serious public health threat and warrants immediate action. Therefore, it is necessary to enhance the antibacterial activity of colistin through the combination with other drugs. In this study, we demonstrate the synergistic activity of colistin combined with PFK-158 against colistin-susceptible but more importantly against colistin-resistant Gram-negative bacteria, including non-fermenting bacteria (P. aeruginosa, A. baumannii) and Enterobacteriaceae (E. coli and K. pneumoniae).Methods: 18 colistin-resistant and 12 colistin-susceptible Gram-negative bacteria were collected as the experimental strains, and the minimum inhibitory concentrations (MICs) of colistin and PFK-158 against all strains were determined by the broth microdilution method. The MICs of routine antimicrobial agents including aztreonam (ATM), ceftazidime (CAZ), cefepime (FEP), imipenem (IMP), ciprofloxacin (CIP), levofloxacin (LVX), gentamicin (GEN), tobramycin (TOB) for all 30 experimental strains were determined by bioMerieux VITEK-2 (BioMérieux, Marcy-l’Étoile, France). The synergistic activity of colistin combined with PFK-158 in vitro was assessed using the checkerboard assay and the time-kill assays.Results: The results of the checkerboard assay showed that when colistin was used in combination with PFK-158, synergistic activity was observed against the 18 colistin-resistant and the 8 colistin-susceptible Gram-negative bacteria, and the remaining 4 colistin-susceptible strains showed additive activity. No irrelevant activity and antagonistic activity was observed for all strains. The results of the time-killing assays presented that the killing activity against the colistin-resistant Gram-negative bacterium were evident for the combination of colistin and PFK-158, compared with the groups adding colistin or PFK-158 alone. Conclusions: In conclusion, our results strongly exhibited that the combination of colistin and PFK-158 displayed the significant synergistic activity against all tested colistin-resistant and most colistin-susceptible Gram-negative strains. PFK-158 was found to potentiate the antibacterial activity of colistin against a wide panel of colistin-resistant and colistin-susceptible Gram-negative strains no matter what species (including non-fermenting bacteria and Enterobacteriaceae). It may be a potential new choice for the treatment of infections caused by the clinical Gram-negative strains.
Vincosamide inhibits malignant behaviors of hepatocellular carcinoma cells by activating caspase-3 activity and blocking the PI3K/AKT signaling pathway
Authors: Zhu Mingyue , Feng Haipeng , Lin Bo , Zhou Ying , Zheng Yifeng , Liu Kun , Li Mengsen 
Published: October 2020

Abstract
Background: Vincosamide(Vinco) was first identified in the methanolic extract of the leaves of Psychotria leiocarpa, and Vinco has important anti-inflammatory effects and activity against cholinesterase, Vinco also has a trait to ant-tumor. However, whether Vinco is able to inhibit the malignant behaviors of hepatocellular carcinoma(HCC) cells is still unclear. In the present study, we explored the role of Vinco in suppressing the malignant behaviors of HCC cells.Methods: MTT, trypan blue exclusion assay and the Cell Counting Kit(CCK)-8 analysis were applied to detect the proliferation and death of HCC cells; electron microscopy was performed to observe the change of cellular mitochondrial morphology; scratch repair and Transwell assays were used to analyze the migration and invasion of HCC cells; the expression and localization of proteins were detected by laser confocal microscopy and Western blotting; and the growth of the cancer cells in in vivo was assessed in a mouse tumorous model.Results: At a dose of 10-80 mg/ml, Vinco inhibited the proliferation and promoted death of HCC cells in a dose-independent manner, but had low cytotoxcity effect on normal liver cells. Additionally, 80 mg/ml of Vinco could significantly disrupt the morphology of mitochondria, suppress the migration and invasion of HCC cells. The growth of HCC cells in the animal tumorous model was significantly inhibited after treatment with Vinco (10 mg/kg/day) for 3 days. The results of the present study indicated that Vinco (10-80 mg/ml) played a role in activating caspase-3, promoting the expression of PTEN, and inhibiting the phosphorylation of AKT(Ser473) and mTOR(Thr2448), Vinco also has a trait for suppressing the expression of CXCR4, Src, MMP9, EpCAM, Ras and Oct4 in HCC cells.Conclusions: Vinco has a role in inhibiting the malignant behaviors of HCC cells; the role molecular mechanism of Vinco maybe involve in restraining expression of the growth-, metastasis-related factors Src, Ras, MMP9, EpCAM and CXCR4, and activating the activity of caspase-3. Vinco also could block PI3K/AKT signaling pathway. Thus, Vinco is an available chemotherapy for HCC patients.
Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters
Authors: Yuan Shuofeng , Yin Xin , Meng XiangZhi , Chan Jasper , Ye Zi-Wei , Riva Laura , Pache Lars , Chan Chris Chun-Yiu , Lai Pok-Man , Chan Chris , Poon Vincent , Matsunaga Naoko , Pu Yuan , Yuen Chun-Kit , Cao Jianli , Liang Ronghui , Tang Kaiming , Sheng Li , Du Yushen , Xu Wan , Sze Kong-Hung , Zhang Jinxia , Chu Hin , Kok Kin-Hang , To Kelvin , Jin Dong-Yan , Sun Ren , Chanda Sumit , Yuen Kwok-Yung 
Published: October 2020

Abstract
COVID-19 pandemic is the third zoonotic coronavirus (CoV) outbreak of the century after severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) since 2012. Treatment options for CoVs are largely lacking. Here, we show that clofazimine, an anti-leprosy drug with a favorable safety and pharmacokinetics profile, possesses pan-coronaviral inhibitory activity, and can antagonize SARS-CoV-2 replication in multiple in vitro systems, including the human embryonic stem cell-derived cardiomyocytes and ex vivo lung cultures. The FDA-approved molecule was found to inhibit multiple steps of viral replication, suggesting multiple underlying antiviral mechanisms. In a hamster model of SARS-CoV-2 pathogenesis, prophylactic or therapeutic administration of clofazimine significantly reduced viral load in the lung and fecal viral shedding, and also prevented cytokine storm associated with viral infection. Additionally, clofazimine exhibited synergy when administered with remdesivir. Since clofazimine is orally bioavailable and has a comparatively low manufacturing cost, it is an attractive clinical candidate for outpatient treatment and remdesivir-based combinatorial therapy for hospitalized COVID-19 patients, particularly in developing countries. Taken together, our data provide evidence that clofazimine may have a role in the control of the current pandemic SARS-CoV-2, endemic MERS-CoV in the Middle East, and, possibly most importantly, emerging CoVs of the future.
Reusability of P3 facial filter in pandemic emergency: a 3D Analysis of a filter microstructure with X-Ray micro-tomography images after dry heat and UV sterilization procedures.
Authors: Borro Luca , Raponi Massimiliano , Fattore Andrea Del , Zanini Franco , Lillo Francesca Di , Contillo Adriano , Piazza Eleonora Di , Bordonaro Veronica , Tozzi Alberto Eugenio , Secinaro Aurelio 
Published: October 2020

Abstract
Objective: We sought to evaluate the effects of heating and UltraViolet (UV) sterilization on level 3 protection microstructure (P3) used on disposable filtering facepieces.Intervention: P3 facial filter has been exposed to dry heat and UV sterilization procedures.Methods: P3 facial filter samples underwent standardized sterilisation processes based on dry heat and UV irradiation techniques. We analysed key parameters of internal microstructure, such as fibres thickness and porosity, before and after sterilization using 3D data obtained with a synchrotron radiation based X-ray computed microtomography (Micro-CT). The analyzed filter has two inner layers that we called "finer" and "coarser" layers. The "finer" layer consists of a dense fibers network while the "coarser" layer has a less compact fiber network. Results: Analysis on 3D images showed no statistically significant differences between P3 Filter of Controls and dry heat/UV sterilized samples. In particular, averages fibres thickness in the finer layer of Controls, 60° dry heated and UV irradiated samples group was almost identical for each group. Average fibres thickness for coarser layer of Controls, 60° dry heated and UV irradiated samples group was very similar measuring 19.33 µm (±0.47), 18.33 µm (±0.47) and 18.66 µm (±0.47), respectively. Of note, there was no substantial difference in fibres maximum thickness in the finer layers and coarser layers. For Controls group samples maximum thickness was on average of 11.43 µm (±1.24) in the finer layer and 59.33 µm (±6.79) in the coarser layer. Similarly, 60° dry heated group samples were thickened 12.2 µm (±0.21) in the finer layer and 57.33 µm (±1.24) in the coarser layer, while UV irradiated samples group the mean max thickness is 12.23 µm (±0.90) in the finer layer and 58.00 µm (±6.68) in the coarser layer.Theoretical porosity analysis resulted of 74% and 88%, for finer and coarser layer, respectively. Theoretical porosity of finer layers tend to decrease on dry heat and UV irradiated samples when compared with the respective controls samples.Conclusions: Dry heat and UV sterilization processes do not substantially alter morphometry of the internal microstructure of the P3 filter samples studied with Micro-CT. The current study suggests that safe P3 filter facepiece reusability is theoretically feasible and should be further investigated.
Errores en el análisis factorial de escala de ansiedad de Zung en una muestra colombiana
Authors: Cassiani-Miranda Carlos Arturo 
Published: October 2020

El 18-04-2020 apareció publicada en Duazary una carta al editor que evaluó el desempeño psicométrico de Zung Self-Rating Anxiety Scale-15 (SAS-15). En aras de contribuir a promover la discusión constructiva sobre la literatura publicada en su revista hago algunas consideraciones críticas: En primer lugar, hay que recordar que el primer paso en la validación de una escala es la adecuada selección de la misma.
Anti-cancer Immunotoxins, Challenges, and Approaches
Authors: Dashtiahangar Maryam , Rahbarnia Leila , Farajnia Safar , Salmaninejad Arash , Shabgah Arezoo Gowhari , Ghasemali Samaneh 
Published: October 2020

:The development of recombinant immunotoxins (RITs) as a novel therapeutic strategy has made a revolution in the treatment of cancer. RITs result from the fusion of antibodies to toxin proteins for targeting and eliminating cancerous cells by inhibiting protein synthesis. Despite indisputable outcomes of RITs regarding inhibition of multiple cancer types, high immunogenicity has been known as the main obstacle in the clinical use of RITs. Various strategies have been proposed to overcome these limitations, including immunosuppressive therapy, humanization of the antibody fragment moiety, generation of immunotoxins originated from endogenous human cytotoxic enzymes, and modification of the toxin moiety to escape the immune system. This paper is devoted to review recent advances in the design of immunotoxins with lower immunogenicity.
Withdrawal Notice: Therapeutic Options for Treatment of COVID-19: A Review from Repurposed Drugs to New Drug Targets
Authors: Akhtar Bushra , Muhammad Faqir , Sharif Ali , Hannan Abdul 
Published: October 2020

The article has been withdrawn from the journal <b>“Current Drug Targets”</b> due to the English language issues.

Bentham Science apologizes to its readers for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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It is a condition of publishers that manuscripts submitted to this journal should not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and while submitting- ting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers, if and when the article is accepted for publication.
A Comparative Survey on Antioxidant Activity of Iranian Shrimp Waste (Penaeus semisulcatus) and Synthetic Antioxidants
Authors: Saatloo Naiema Vakili , Peivasteh-Roudsari Leila , gharehgheshlaghi Hadi Eghbaljoo , Khaniki Gholamreza Jahed , Nodehi Ramin Nabizadeh , Alimohammadi Mahmood , Sadighara Parisa 
Published: October 2020

Shrimp waste, as an important source of natural carotenoids, is produced in large quantities in seafood processing
industry. One of the important characteristics of carotenoids is their ability to act as antioxidants, thus protecting cells and
tissues from damaging effects of free radicals and singlet oxygen. The aim of this study was to find effective method for carotenoid
extraction [Enzymatic and alkaline treatment] from shrimp waste and compare their antioxidant potential with synthetic
antioxidants butylated hydroxyanisole [BHA] and butylated hydroxytoluene [BHT] using sunflower oil. The sunflower
oil was exposed to three concentration of extracted carotenoid [470, 235 and 118 mg/kg] and synthetic antioxidants. The
inhibition of lipid peroxidation was evaluated for Malondialdehyde and peroxide value.
The mean values of carotenoid extract were 243 and 170 mg/kg for enzymatic and alkaline treatment, respectively. So the
highest efficacy of carotenoid extraction was obtained from enzymatic extraction. The oil samples containing 470 ppm carotenoid,
which extracted by alcalase as the default treatment, exhibited the less peroxide value and higher antioxidant potential
than the oil samples containing synthetic antioxidants. According to the results, the synthetic antioxidants can be replaced
by extracted carotenoids from shrimp waste as a natural antioxidant to inhibit oxidation.
MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice
Authors: He Ning , Zheng Xiaohe , He Teng , Shen Gerong , Wang Kunyu , Hu Jue , Zheng Mingzhi , Ding Yueming , Song Xinghui , Zhong Jinjie , Chen Ying-Yung , Wang Lin-Lin , Yueliang Shen 
Published: October 2020

Background:
Traumatic Spinal Cord Injury (SCI) is a severe condition usually accompanied
by an inflammatory process that gives rise to uncontrolled local apoptosis and a subsequent
unfavorable prognosis. One reason for this unfavorable outcome could be the activation of the NLRP3
inflammasome.

Objective:
MCC950 is a specific inhibitor of NLRP3 that further inhibits the formation of the NLRP3
inflammasome. The purpose of this study was to determine whether the NLRP3 inflammasome
was associated with the severity of local apoptosis and whether MCC950 could prevent neuronal
apoptosis following SCI.

Methods:
In this study, primary cortical neurons were cultured in vitro. With or without pretreatment/
posttreatment with MCC950, neurons were subjected to Oxygen-Glucose Deprivation (OGD)
for 2 h and then reperfusion for 20 h. Immunofluorescence was used to determine the expression of
NLRP3, ASC, and cleaved caspase-1 in neurons. In vivo, SCI model mice were established with a
5 g weight-drop method. MCC950 was intraperitoneally injected at 0, 2, 4, 6, 8, 10, and 12 days after
SCI. Basso Mouse Scale (BMS) scores and footprint assays were used to assess motor function.
Paw withdrawal threshold and tail-flick latency were used to assess somatosensory function. H&E,
Nissl, and TUNEL staining were used to measure histological changes and apoptosis at 3 days after
SCI, and scar formation was observed by Masson staining and GFAP immunohistochemical analysis
at 28 days after SCI.

Results:
Immunofluorescence analysis confirmed that MCC950 inhibited OGD-induced activation
of the NLRP3 inflammasome in neurons. Behavioral tests, Masson staining, and GFAP immunohistochemical
analysis showed that MCC950-treated mice had improved neuronal functional recovery
and reduced scar formation at 28 days after SCI. H&E, Nissl, and TUNEL staining confirmed that
there were more living neurons and fewer apoptotic neurons in MCC950-treated mice than control
mice at 3 days after SCI.

Conclusion:
These results reveal that MCC950 exerts neuroprotective effects by reducing neuronal
apoptosis, preserving the survival of the remaining neurons, attenuating the severity of the damage,
and promoting the recovery of motor function after SCI.
Withdrawal Notice: COVID-19: Outbreak to Global
Authors: Paliwal Deepika , Khan Shoaib , Chaki Anindita 
Published: October 2020

The article for the journal Anti-Infective Agents; has been removed by the Publisher due to acute language inconsistencies and
grammatical errors.

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:
It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Development and Realization of a Computer Monitoring System Based on a Power Network
Authors: Qin Qin 
Published: October 2020

Background:
To solve an electric power enterprise for a safe operation of power systems.

Methods:
A data acquisition technology based on multi-thread mechanism of data collection technology
is proposed; its application may provide a data acquisition rate of 1832/min and an update cycle of
approximately 30 s to ensure efficient and reliable performance on a large-scale electric power realtime
data acquisition.

Results:
A power state index diagnosis algorithm is designed.

Conclusion:
The on-line real-time diagnosis of the current operating state for the power system is realized,
and its importance is given.
QSAR to Design an Effective Eco-friendly Inhibitor Model from Chitosan Derivatives Sea-food Waste based on DFT Calculations and Experimental Study
Authors: El Sayed Doaa S. , Makhyoun Mohamed A. 
Published: October 2020

Background:A density functional theory (DFT) study of some selected eco-friendly chitosan derivatives was performed, recently used as corrosion inhibitors for steel in 0.1M and 0.5M HCl. Correlation between observed and predicted inhibition efficiencies is based on QSAR by some statistical calculations.Methods:We extracted the optimum molecular descriptors for the chitosan derivatives group under study and it was found that these descriptors have a proper effect on increasing the inhibition efficiency that was proved by applying the theoretical calculations (non-linear regression) on two models of chitosan derivatives (ChI and ChII). The quantum chemical descriptors most relevant to the corrosion inhibitors potential effect have been calculated in the aqueous phase. They include: EHOMO, ELUMO, dipole moment (D), molecular area (MA), molecular volume (MV), the charge on common oxygen (O Charge), the charge on common nitrogen (N Charge), nuclear repulsion energy (NRE), final single point energy (E) and total positive charge (TPC).Results:The optimum parameters resulted using multiple linear regression are EHOMO, CCO, CCN, and D. Using these optimum parameters, the models designed show good results in their inhibition effect on steel at the same environment of the chitosan derivatives group under study.Conclusion:Experimental explanation showed good results from modelling prediction, where the corrosion rate decreases markedly with increasing the concentration of the designed inhibitors till the optimum concentration where the rate becomes constant. SEM on the optimum inhibitor concentration proved the high inhibition efficiency obtained.