bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental study on seepage characteristics of microfracture with different aperture
Authors: Zhang Shuai , Qiao Weiguo , Wu Yue , Fan Zhenwang , Zhang Lei 
Published: March 2020

AbstractExploring the flow mechanism of fluid in rock mass is important in solving the water inrush problems during tunnel excavation. However, it is difficult to obtain an undisturbed rock mass from the actual site conditions and study the flow mechanism of fluid through a fracture network composed of multiple single fractures. Therefore, a solution to simulate rock seepage using rock-like samples with single microfracture was presented in this paper. Water flow through microfracture was tested and the deformation of microfracture was recorded by quasi-distributed fiber Bragg grating (FBG) technology. Experimental data showed that Forchheimer’s law and Izbash’s law could well describe the nonlinear relationship between flow velocity and hydraulic gradient. The coefficientbin Forchheimer’s equation decreased with the increase of microfracture aperture. A critical value of E = 0.8 was proposed to classify the nonlinear flow regime: weak turbulence (E < 0.8) and fully developed turbulence (E > 0.8).
Recovery of Yam Soluble Protein from Yam Starch Processing Wastewater
Authors: Xue Heng-Yue , Zhao Yue , Liu Zi-Heng , Wang Xiao-Wen , Zhang Jun-Wei , Peng Xue , Tanokura Masaru , Xue You-Lin 
Published: March 2020

AbstractOver the past two decades, many studies have shown that the yam storage protein dioscorin, which is abundant in the wastewater of starch processing, exhibits many biological activities both in vitro and in vivo. In the present study, the acid-precipitation method was optimized using Box-Behnken design (BBD) combined with response surface methodology (RSM) for the recovery of yam soluble protein (YSP) from wastewater. The experimental yield of YSP reached 57.7%. According to relative quantitative proteomics (LC-MS/MS), the crude YSP was mainly composed of 15 dioscorin isoforms, which was further verified by anion-exchange and size-exclusion chromatography. YSP was found to be rich in glutamic acid and aspartic acid, and the eight essential acids made up approximately 33.7% of the YSP. Moreover, the YSP demonstrated antioxidant activity, including scavenging DPPH, hydroxyl and superoxide anion radicals, and the possible structure-activity relationships were discussed. These results indicated that YSP produced by acid precipitation may be used as a protein source with antioxidant properties.
Subgrouping Poor Sleep Quality in Community-Dwelling Older Adults with Latent Class Analysis - The Yilan Study, Taiwan
Authors: Chen Hsi-Chung , Hsu Nai-Wei , Chou Pesus 
Published: March 2020

AbstractThe manifestation of older adults with poor sleep quality is heterogeneous. Using data-driven classifying methods, the study aims to subgroup community-dwelling older adults with poor sleep quality. Adults aged 65 and older participated in the Yilan study. Poor sleep quality was defined using the Pittsburgh Sleep Quality Index. Latent class analysis with the 7 subscores of the Pittsburgh Sleep Quality Index as the indicators was used to generate empirical subgroups. Differences in comorbidity patterns between subgroups were compared. A total of 2622 individuals, of which 1011 (38.6%) had Pittsburgh Sleep Quality Index -defined poor sleep quality, participated. Three groups for poor sleep quality were specified in the latent class analysis: High Insomnia (n = 191, 7.3%), Mild Insomnia (n = 574, 21.9%), and High Hypnotics (n = 246, 9.4%). The High Insomnia and Mild Insomnia groups shared similar profiles but different severities in the 7 domains of the Pittsburgh Sleep Quality Index. In contrast, the High Hypnotics group had the lowest Pittsburgh Sleep Quality Index total scores and insomnia severity but had similar mental and physical comorbid patterns as the High Insomnia group. This finding suggests that poor sleep quality in community-dwelling older adults had various feature-based subgroups. It also implicates the development of group-centered interventions.
Alzheimer’s disease, mild cognitive impairment, and normal aging distinguished by multi-modal parcellation and machine learning
Authors: Sheng Jinhua , Shao Meiling , Zhang Qiao , Zhou Rougang , Wang Luyun , Xin Yu 
Published: March 2020

AbstractA 360-area surface-based cortical parcellation is extended to study mild cognitive impairment (MCI) and Alzheimer’s disease (AD) from healthy control (HC) using the joint human connectome project multi-modal parcellation (JHCPMMP) proposed by us. We propose a novel classification method named as JMMP-LRR to accurately identify different stages toward AD by integrating the JHCPMMP with the logistic regression-recursive feature elimination (LR-RFE). In three-group classification, the average accuracy is 89.0% for HC, MCI, and AD compared to previous studies using other cortical separation with the best classification accuracy of 81.5%. By counting the number of brain regions whose feature is in the feature subset selected with JMMP-LRR, we find that five brain areas often appear in the selected features. The five core brain areas are Fusiform Face Complex (L-FFC), Area 10d (L-10d), Orbital Frontal Complex (R-OFC), Perirhinal Ectorhinal (L-PeEc) and Area TG dorsal (L-TGd, R-TGd). The features corresponding to the five core brain areas are used to form a new feature subset for three classifications with the average accuracy of 80.0%. Results demonstrate the importance of the five core brain regions in identifying different stages toward AD. Experiment results show that the proposed method has better accuracy for the classification of HC, MCI, AD, and it also proves that the division of brain regions using JHCPMMP is more scientific and effective than other methods.
Visual appearance of the virtual hand affects embodiment in the virtual hand illusion
Authors: Pyasik Maria , Tieri Gaetano , Pia Lorenzo 
Published: March 2020

AbstractBody ownership (the feeling that one’s body belongs to oneself) is commonly studied with Rubber hand illusion (RHI) paradigm that allows inducing a temporary illusory feeling of ownership of a life-sized rubber hand. However, it remains unclear whether illusory ownership of the fake hand relies on the same mechanisms as ownership of one’s own real hand. Here, we directly compared ownership of the own hand (OH) and fake hand (FH) in the same set of conditions within immersive virtual reality. We obtained behavioral (proprioceptive drift) and subjective (questionnaire) measures of ownership and disownership for virtual OH, FH and object (Obj) that were located congruently or incongruently with the participant’s real hand and were stimulated synchronously or asynchronously with the real hand. Both OH and FH (but not Obj) were embodied after synchronous stimulation in both locations. Crucially, subjective ownership of the OH was stronger than of the FH in congruent location after synchronous stimulation. It was also present after asynchronous stimulation, being stronger when the virtual OH was subjectively more similar to the real hand. The results suggest that the detailed appearance of the body might act as an additional component in the construction of body ownership.
Infrared Spectroscopic Imaging Visualizes a Prognostic Extracellular Matrix-Related Signature in Breast Cancer
Authors: Tiwari Saumya , Triulzi Tiziana , Holton Sarah , Regondi Viola , Paolini Biagio , Tagliabue Elda , Bhargava Rohit 
Published: March 2020

AbstractMolecular analysis techniques such as gene expression analysis and proteomics have contributed greatly to our understanding of cancer heterogeneity. In prior studies, gene expression analysis was shown to stratify patient outcome on the basis of tumor-microenvironment associated genes. A specific gene expression profile, referred to as ECM3 (Extracellular Matrix Cluster 3), indicated poorer survival in patients with grade III tumors. In this work, we aimed to visualize the downstream effects of this gene expression profile onto the tissue, thus providing a spatial context to altered gene expression profiles. Using infrared spectroscopic imaging, we identified spectral patterns specific to the ECM3 gene expression profile, achieving a high spectral classification performance of 0.87 as measured by the area under the curve of the receiver operating characteristic curve. On a patient level, we correctly identified 20 out of 22 ECM3 group patients and 19 out of 20 non-ECM3 group patients by using this spectroscopic imaging-based classifier. By comparing pixels that were identified as ECM3 or non-ECM3 with H&E and IHC images, we were also able to observe an association between tissue morphology and the gene expression clusters, showing the ability of our method to capture broad outcome associated features from infrared images.
Spatially resolved determination of the electronic density and temperature by a visible spectro-tomography diagnostic in a linear magnetized plasma
Authors: Gonzalez-Fernandez V.  , David P. , Baude R. , Escarguel A. , Camenen Y. 
Published: March 2020

AbstractIn this work, a non-intrusive, spatially resolved, spectro-tomographic optical diagnostic of the electronic density and temperature on the linear plasma column Mistral is presented. Coupling of spectroscopy and tomography technique gives access to the local plasma light emission at different wavelengths (visible and near IR) in an argon plasma. Taking advantage of the symmetry of the Mistral experiment, the diagnostic results are validated and the plasma is found to correspond to a corona equilibrium state. With the use of another spectrometer and a Langmuir probe, we propose a non-intrusive method to determine the electronic density and temperature of each pixel of the tomographic images of the plasma. The obtained results are in good agreement with the Langmuir probe ones.
Thyroid autoantibodies in adults with acquired binocular diplopia of unknown origin
Authors: Lee Haeng-Jin , Kim Seong-Joon 
Published: March 2020

AbstractPatients with acquired adult-onset strabismus mainly present with binocular diplopia. Although cranial nerve palsies are reportedly the most common cause of binocular diplopia in adults, thyroid disease can also cause diplopia. In patients with thyroid-associated ophthalmopathy, upper lid retraction and proptosis are the most common initial findings, but diplopia could be the first manifestation. So far, there has been little information on the diagnostic value of thyroid autoantibodies in patients with strabismus. Therefore, we examined adults with acquired binocular diplopia from 2008 to 2016 and evaluated the presence of thyroid autoantibodies and the relationship between thyroid autoantibody status and clinical characteristics in adults with acquired binocular diplopia. Thyroid autoantibody tests were performed for all patients, unless other causes of diplopia were identified. Fifty one (39%) of 132 patients were positive for thyroid autoantibodies. In the thyroid autoantibody-positive (TAb+) group, microsomal autoantibodies, thyroid-stimulating hormone receptor antibodies, thyroglobulin antibodies, and thyroid-stimulating antibodies were observed in 30, 27, 12, and 7 patients, respectively. The vertical deviation and grade of duction limitation were greater in the TAb+ group. The presence of ocular torsion was 15.5% and 39.5% in the TAb− and TAb+ groups, respectively. Thyroid autoantibody evaluation may be helpful in adults with idiopathic acquired binocular diplopia.
Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms
Authors: Velentzas Athanassios D. , Katarachia Stamatia A. , Sagioglou Niki E. , Tsioka Maria M. , Anagnostopoulos Athanasios K. , Mpakou Vassiliki E. , Theotoki Eleni I. , Giannopoulou Aikaterini F. , Keramaris Konstantinos E. , Papassideri Issidora S. , Tsangaris George Th. , Stravopodis Dimitrios J. 
Published: March 2020

AbstractDrosophilabrain has emerged as a powerful model system for the investigation of genes being related to neurological pathologies. To map the proteomic landscape of fly brain, in a high-resolution scale, we herein employed a nano liquid chromatography-tandem mass spectrometry technology, and high-content catalogues of 7,663 unique peptides and 2,335 single proteins were generated. Protein-data processing, through UniProt, DAVID, KEGG and PANTHER bioinformatics subroutines, led to fly brain-protein classification, according to sub-cellular topology, molecular function, implication in signaling and contribution to neuronal diseases. Given the importance of Ubiquitin Proteasome System (UPS) in neuropathologies and by using the almost completely reassembled UPS, we genetically targeted genes encoding components of the ubiquitination-dependent protein-degradation machinery. This analysis showed that driving RNAi toward proteasome components and regulators, using the GAL4-elav.L driver, resulted in changes to longevity and climbing-activity patterns during aging. Our proteomic map is expected to advance the existing knowledge regarding brain biology in animal species of major translational-research value and economical interest.
Universal flux patterns and their interchange in superconductors between types I and II
Authors: Vagov A. , Wolf S. , Croitoru M. D. , Shanenko A. A. 
Published: March 2020

AbstractExperiments with the crossover superconductors between standard types I and II revealed exotic magnetic flux patterns where Meissner domains coexist with islands of the vortex lattice as well as with vortex clusters and chains. Until now a comprehensive theory for such configurations has not been presented. We solve this old-standing fundamental problem by developing an approach which combines the perturbation expansion of the microscopic theory with statistical simulations and which requires no prior assumption on the vortex distribution. Our study offers the most complete picture of the interchange of the superconductivity types available so far. The mixed state in this regime reveals a rich manifold of exotic configurations, which reproduce available experimental results. Our work introduces a pattern formation mechanism that originates from the self-duality of the theory that is universal and not sensitive to the microscopic details.
Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine
Authors: Didier Pascal , Kuchlyan Jagannath , Martinez-Fernandez Lara , Gosset Pauline , Léonard Jérémie , Tor Yitzhak , Improta Roberto , Mély Yves 
Published: March 2020

Proposed photophysics of thGb under acidic conditions.
Factors Influencing Presence or Absence of Laterality During Pharyngeal Bolus Clearance
Authors: Garand Kendrea L. , Thomas Taylor , Dey Rajarshi 
Published: March 2020

Purpose
The aim of this study was to identify factors influencing pharyngeal laterality of bolus clearance through the pharyngoesophageal segment.

Method
Two swallowing trials (5-ml nectar-thickened liquid and 5-ml pudding) administered in the anteroposterior viewing plane during videofluoroscopy were extracted from a normative database of 195 healthy adult participants. Each swallow was determined as either having no laterality, right dominance/right side only, or left dominance/left side only. Descriptive measures were performed on all data variables. Chi-square tests were performed to determine the relationship between laterality and several factors, including age category, sex, race, and swallow task.

Results
The majority of swallows demonstrated no laterality. No significant associations were observed between laterality and the following factors: age category, race, or swallow task. Significant differences in laterality were observed between males and females, with females more likely to demonstrate no laterality.

Conclusions
Majority of swallows in the current healthy sample demonstrated no laterality preference. If present, males were more likely to demonstrate laterality compared to females. Laterality observed during videofluoroscopy does not imply impairment if there are no other factors present influencing bolus flow into the esophagus (e.g., mass). Study findings further define typical swallowing behaviors, allowing clinicians to better delineate normal variations from true impairment. Further research should include a larger sample of individuals aged 80 years and older, as well as additional swallowing tasks, to further investigate patient- and bolus-related factors on laterality.
Compact dual‐band balanced SIW bandpass filter with two adjustable closed‐passbands
Authors: Liu Yijie , Zhang Gang , Zheng Jian 
Published: March 2020

A new compact multilayer dual‐band‐balanced bandpass filter (BPF) with two flexibly adjustable closed‐passbands based on substrate‐integrated waveguide (SIW) resonator is proposed in this letter. Both TE102‐mode and TE201‐mode of the resonator are utilised to achieve desired differential mode (DM) transmission and high common mode suppression. Two SIW cavities are properly coupled in the back‐to‐back form to realise a closed dual‐passband‐balanced response by virtue of singly one cruciform coupling aperture etched on the ground. Additionally, two pairs of perturbed slotlines are elaborately introduced on the top and bottom layers to perturb the resonant frequencies of TE102‐mode and TE201‐mode, realising both adjustable upper‐ and lower‐DM passbands. For demonstration, a prototype dual‐band‐balanced SIW BPF operating at 12.7 and 15.5 GHz is designed, fabricated and tested. Measured and simulated results are in good agreement, verifying the feasibility of the design concept.
Model exploration of near-IR ro-vibrational CO emission as a tracer of inner cavities in protoplanetary disks
Authors: Antonellini S. , Banzatti A. , Kamp I. , Thi W.-F. , Woitke P. 
Published: March 2020

Context. Near-IR observations of protoplanetary disks provide information about the properties of the inner disk. High-resolution spectra of abundant molecules such as CO can be used to determine the disk structure in the warm inner parts. The v2∕v1 ro-vibrational ratio of v1−0 and v2−1 transitions has recently been observed to follow distinct trends with the CO emitting radius in a sample of TTauri and Herbig disks; these trends have empirically been interpreted as due to depletion of the inner disk from gas and dust.
Aims. We use thermochemical disk models to explore the to interpret the trends of these CO ro-vibrational CO emission.
Methods. We used the radiation thermochemical code ProDiMo to explore a set of previously published models with different disk properties and varying one parameter at a time: the inner radius, the dust-to-gas mass ratio, and the gas mass. In addition, we used models in which we changed the surface density power-law index, and employed a larger set of CO ro-vibrational levels that also include fluorescence from the first electronic state. We investigated these models for TTauri and Herbig star disks. Finally, we included a set of DIANA models for individual TTauri and Herbig disks that were constructed to reproduce a large set of multiwavelength observations.
Results. This modeling exploration highlights promising parameters that may explain the observed trends in ro-vibrational CO emission. Our models with an increasing inner radius match the observed trend for TTauri disks, in which we were also able to account for the vertical spread in the data by different values for the dust-to-gas mass ratio and for the disk gas mass in different disks. Our models instead match the CO vibrational ratio observed in Herbig disks only in the case of large inner holes and cannot produce the low ratios that are measured in many disks. The models do produce an inversion in the trend, where v2−1∕v1−0 increases and does not decrease for CO radii larger than a few au. The reason for this is that the P(4) v2−1 line becomes optically thin and superthermally excited. In our models, this does not require invoking UV fluorescence pumping.
Conclusions. Our modeling explorations suggest that the observed decrease in v2−1∕v1−0 with CO radius in TTauri disks might be a consequence of inside-out disk depletion. For the Herbig disks, a more complex inner disk structure may instead be needed to explain the observed trends in the excitation of CO emission as a function of emitting radius: disk gaps emptied of dust, partially depleted in gas, and/or possibly a disk structure with an inverted surface density profile. These structures need to be further investigated in future work.
Tidal and general relativistic effects in rocky planet formation at the substellar mass limit using N-body simulations
Authors: Sánchez Mariana B. , de Elía Gonzalo C. , José Downes Juan 
Published: March 2020

Context. Recent observational results show that very low mass stars and brown dwarfs are able to host close-in rocky planets. Low-mass stars are the most abundant stars in the Galaxy, and the formation efficiency of their planetary systems is relevant in the computation of a global probability of finding Earth-like planets inside habitable zones. Tidal forces and relativistic effects are relevant in the latest dynamical evolution of planets around low-mass stars, and their effect on the planetary formation efficiency still needs to be addressed.
Aims. Our goal is to evaluate the impact of tidal forces and relativistic effects on the formation of rocky planets around a star close to the substellar mass limit in terms of the resulting planetary architectures and its distribution according to the corresponding evolving habitable zone.
Methods. We performed a set of N-body simulations spanning the first 100 Myr of the evolution of two systems composed of 224 embryos with a total mass 0.25 M⊕ and 74 embryos with a total mass 3 M⊕ around a central object of 0.08 M⊙. For these two scenarios we compared the planetary architectures that result from simulations that are purely gravitational with those from simulations that include the early contraction and spin-up of the central object, the distortions and dissipation tidal terms, and general relativistic effects.
Results. We found that including these effects allows the formation and survival of a close-in (r < 0.07 au) population of rocky planets with masses in the range 0.001 < m∕M⊕ < 0.02 in all the simulations of the less massive scenario, and a close-in population with masses m ~ 0.35 M⊕ in just a few of the simulations of the more massive scenario. The surviving close-in bodies suffered more collisions during the integration time of the simulations. These collisions play an important role in their final masses. However, all of these bodies conserved their initial amount of water in mass throughout the integration time.
Conclusions. The incorporation of tidal and general relativistic effects allows the formation of an in situ close-in population located in the habitable zone of the system. This means that both effects are relevant during the formation of rocky planets and their early evolution around stars close to the substellar mass limit, in particular when low-mass planetary embryos are involved.
La constellation transférentielle au sein de l’équipe de La Velotte
Authors: Pointurier Amélie , Descourty Annie , Joedicke Christophe 
Published: March 2020

Cet article présente le travail en équipe au sein du Centre psychothérapiquee de La Velotte. À travers une présentation clinique nous montrons comment la constellation transférentielle se déploie au cœur de notre équipe, et comment elle nous permet de restituer au patient les différentes parties clivées qu’il a pu projeter à l’extérieur de lui-même. Nous soulignons la notion de « solution délirante », ou de respect de l’espace délirant, qu’il est indispensable de préserver au cours d’un cheminement psychique comme celui qu’Alban effectue à l’Hôpital de Jour de La Velotte. Nous montrons également comment nous tentons de le rejoindre afin d’installer un espace psychique partagé, de co-thérapie, qui va lui permettre d’avancer dans le travail d’autonomie psychique et pragmatique qu’il a à faire pour construire sa vie.