bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulated CARD11 signaling in the development of diffuse large B cell lymphoma
Authors: Jones Tyler A. , Hutcherson Shelby M. , Bedsaul Jacquelyn R. , Pomerantz Joel L. 
Published: August 2020

CARD11 is a crucial scaffold protein that controls antigen-induced activation of lymphocytes. Upon antigen receptor signaling, CARD11 engages several signaling pathways, leading to the activation of NF-κB, mTOR, and JNK. CARD11 mutations are frequently found in patients with non-Hodgkin lymphoma and their ability to induce aberrant lymphocyte proliferation may be enhanced by mutations in regulators of CARD11 signal transduction. Here we describe how dysregulated CARD11 activity can promote lymphomagenesis through branched signaling pathways whose components and intermediates provide targets for novel diagnostic and therapeutic approaches. Statement of novelty: This review discusses how gain-of-function CARD11 mutations promote lymphomagenesis by engaging branching signaling pathways and how these different pathways provide multiple targets for therapies.
Test-Retest Reliability of Static and Countermovement Power Push-Up Tests in Young Male Athletes
Authors: Bohannon Nicholas A. , Gillen Zachary M. , Shoemaker Marni E. , McKay Brianna D. , Gibson Sydney M. , Cramer Joel T. 
Published: August 2020

Abstract
Bohannon, NA, Gillen, ZM, Shoemaker, ME, McKay, BD, Gibson, SM, Cramer, JT. Test-Retest Reliability of Static and Counter-Movement Power Push-Up Tests in Young Male Athletes. J Strength Cond Res 34(9): 2456–2464, 2020—The primary purpose of this study was to evaluate test-retest reliability of the static (SP) and countermovement (CMP) power push-up test in young male athletes. The secondary purpose was to compare the reliability of vertical ground reaction forces versus torque measurements during the power push-up tests. Twenty boys (age = 11.60 ± 1.15 years) performed SPs and CMPs on force plates with the knees as the fulcrum on 2 laboratory visits separated by 2–7 days. Performance measurements included peak force (PF), peak rate of force development (pRFD), peak torque (PT), peak rate of torque development (pRTD), peak power (PP), average power (AP), eccentric impulse (ECC), and concentric impulse (CON) for both power push-up techniques. Age, maturity offset, height, body mass, fat-free mass, and estimated arm cross sectional area were obtained as measurements of growth. Intraclass correlation coefficients (ICC), SEM, coefficients of variation, and minimum detectable changes (MDC) were reported. Only PF (ICC = 0.87–0.88, SEM = 59–84 N) and PT (ICC = 0.89–0.90, SEM = 60–88 N·m) showed acceptable reliability. Neither pRFD, pRTD, PP, AP, ECC, or CON were reliable outcomes. There were no meaningful differences between force-time and torque-time curve measurements. The SP showed slightly lower CVs (33–34%) than the CMP (CVs = 39–40%). Coaches and practitioners would need to see 58–71% increases in upper-body strength measurements evaluated via power push-up on force plates to be 95% confident that the improvements exceeded the measurement variability.
Peak Torque Explains More Unique Variability in Growth Measurements than Rate of Torque Development in Young Boys and Girls
Authors: Gillen Zachary M. , Shoemaker Marni E. , McKay Brianna D. , Bohannon Nicholas A. , Gibson Sydney M. , Cramer Joel T. 
Published: August 2020

Abstract
Gillen, ZM, Shoemaker, ME, McKay, BD, Bohannon, NA, Gibson, SM, and Cramer, JT. Peak torque explains more unique variability in growth measurements than rate of torque development in young boys and girls. J Strength Cond Res 34(9): 2507–2514, 2020—This study reported test-retest reliability and evaluated collinearity for isometric leg extension and flexion peak torque (PT) and rate of torque development (RTD) in young boys and girls. Measurements of growth included height, body mass, fat-free mass, maturity offset, and leg extensor and flexor muscle cross-sectional area. Maximal isometric contractions quantified PT and RTD. Intraclass correlation coefficients (ICCs), SEM, coefficients of variation, and minimum detectable changes quantified test-retest reliability. Zero-order correlations and first-order partial correlations evaluated collinearity. Peak torque from leg extension and flexion exhibited ICCs ≥ 0.90, RTD from leg extension and flexion exhibited ICCs ≥ 0.38. Partialing out leg flexion PT reduced the relationships between leg extension PT and growth (rPText, growth.PTflex = 0.392–0.605). Partialing out leg extension PT eliminated the relationships between leg flexion PT and growth (rPTflex, growth.PText = 0.098–0.263). Partialing out leg extension RTD reduced the relationships between PT and growth (rPText, growth.RTDext = 0.516–0.775). Partialing out leg extension PT eliminated the relationships between RTD and growth (|rRTDext, growth.PText| = 0.001–0.148). Leg extension PT was more reliable and explained the most unique variability in growth among young boys and girls. In contrast, RTD was less reliable and was fully accounted for by PT, indicating that RTD may be an unnecessary measurement in studies of young boys and girls.
Repeated Application of a Novel Creatine Cream Improves Muscular Peak and Average Power in Male Subjects
Authors: Whinton Alanna K. , Donahoe Katelynn , Gao Ruirui , Thompson Kyle M.A. , Aubry Rachel , Saunders Travis J. , Johnston Adam , Chilibeck Philip D. , Burr Jamie F. 
Published: August 2020

Abstract
Whinton, AK, Donahoe, K, Gao, R, Thompson, KMA, Aubry, R, Saunders, TJ, Johnston, A, Chilibeck, PD, and Burr, JF. Repeated application of a novel creatine cream improves muscular peak and average power in male subjects. J Strength Cond Res 34(9): 2482–2491, 2020—Using a multicenter, randomized controlled trial, (N = 123, age 23 ± 4 years) we sought to determine whether administration of a novel, topical creatine supplement could improve muscular performance after acute and repeated (7-day) exposure. To study the acute performance enhancing effects of the supplement, subjects completed 5 sets of 15 maximal concentric single-leg knee extensions with and without the application of a low- (low dose [LD]-3.5 ml) or high-dose (high dose [HD]-7 ml) topical creatine cream. After a wash-out period, subjects had one leg randomized to receive either the creatine or placebo cream, with further randomization into an oral creatine or placebo supplement group. Subjects completed 5 sets of 15 maximal concentric single leg knee extensions before and after the supplementation protocol. After acute application, no significant differences in peak power (LD: 252 ± 93 W, HD: 261 ± 100 W, p = 0.21), average power (LD: 172 ± 65 W, HD: 177 ± 69 W, p = 0.78), or fatigue index (LD: 13.4 ± 10.6%, HD: 14 ± 11.9%, p = 0.79) were observed between experimental and placebo creams (peak power: LD: 244 ± 76 W, HD: 267 ± 109 W; average power: LD: 168 ± 57 W, HD: 177 ± 67 W; fatigue index: LD: 12.4 ± 9.6%, HD: 12.8 ± 10.6%) or when controlling for sex. After the 7-day supplementation protocol, a significant increase in average power (creatine: 203 ± 61–220 ± 65 W, placebo: 224 ± 61–214 ± 61 W) and peak power (creatine: 264 ± 73–281 ± 80 W, placebo: 286 ± 79–271 ± 73 W) in the leg receiving creatine cream was observed in male subjects. No differences were observed in female subjects. The topical creatine cream did not enhance measures of muscle performance after acute application, but was able to improve peak and average power in male subjects after 7 consecutive days of application.
Retraction
Authors: International ASTM 
Published: August 2020

Abstract
Original Article Title: Comparison of the Dwell Effect of Titanium 6242 Alloy at Room Temperature and 120°C
Authors: Lanzhou Liu,1 Yifei Gao,2 Biao Zhang,3 Tong Niu,3 Peifeng Luan,3 Yanjiang Wang,3 and Xin Chen3
This article has been retracted due to copyright concerns.
ASTM International
September 2020
Distinct Age-Dependent C Fiber-Driven Oscillatory Activity in the Rat Somatosensory Cortex
Authors: Chang Pishan , Fabrizi Lorenzo , Fitzgerald Maria 
Published: August 2020

AbstractWhen skin afferents are activated, the sensory signals are transmitted to the spinal cord and eventually reach the primary somatosensory cortex (S1), initiating the encoding of the sensory percept in the brain. While subsets of primary afferents mediate specific somatosensory information from an early age, the subcortical pathways that transmit this information undergo striking changes over the first weeks of life, reflected in the gradual emergence of specific sensory behaviors. We therefore hypothesized that this period is associated with differential changes in the encoding of incoming afferent volleys in S1. To test this, we compared S1 responses to A fiber skin afferent stimulation and A + C skin afferent fiber stimulation in lightly anaesthetized male rats at postnatal day (P)7, P14, P21, and P30. Differences in S1 activity following A and A + C fiber stimulation changed dramatically over this period. At P30, A + C fiber stimulation evoked significantly larger γ, β, and α energy increases compared with A fiber stimulation alone. At younger ages, the changes in S1 oscillatory activity evoked by the two afferent volleys were not significantly different. Silencing TRPV1+ C fibers with QX-314 significantly reduced the γ and β S1 oscillatory energy increases evoked by A + C fibers, at P30 and P21, but not at younger ages. Thus, C fibers differentially modulate S1 oscillatory activity only from the third postnatal week, well after the functional maturation of the somatosensory cortex. This age-related change in afferent evoked S1 oscillatory activity may underpin the maturation of sensory discrimination in the developing brain.
Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study
Authors: Roumeau Sylvain , Thevenon Joannice , Ouchchane Lemlih , Maqdasy Salwan , Batisse-Lignier Marie , Duale Christian , Pham Dang Nathalie , Caron Philippe , Tauveron Igor , Devoize Laurent 
Published: August 2020

Objective:
The dental and periodontal impact of GH/IGF-1 hypersecretion has been poorly investigated until now. Our aim is to precisely describe the oro-dental state of acromegalic patients and to study the impact of GH/IGF-1 hypersecretion on patients’ reported oral health-related quality of life (OHRQoL).

Methods:
After collecting characteristics of their disease, acromegalic patients answered the GOHAI questionnaire assessing their OHRQoL, the AcroQoL questionnaire and then benefited from a complete stomatological and radiological examination (orthopantomogram systematically, retro-alveolar radiography or Cone Beam CT if necessary).

Results:
In total, 29 patients aged 59.1 ± 16.0 years were included. The average DMFT index (sum of Decayed, Missing and Filled Teeth per patient) was 19.0 ± 7.8. 16/29 patients had a gingivitis and 18/29 a mild to moderate chronic periodontitis, but no case of severe chronic periodontitis was found, probably because the frequency of a protective thick gingival biotype was increased (9/29). No case of generalized gingival hypertrophy or diffuse hypercementosis was observed. According to the Add-GOHAI score, only 8/26 patients had a satisfactory OHRQoL. This parameter was correlated to the acromegaly-specific quality of life according to the AcroQoL score. Interestingly, 11/29 patients had bulky oral bony outgrowths (OBO), such as large maxillary or mandibular tori and multiple vestibular exostosis.

Conclusions:
The unsatisfactory OHRQoL reported by acromegalic patients contrasts with a rather good objective oro-dental state and annual oral examination seems relevant in this population. Finally, we report that huge OBO could be helpful signposts for the diagnosis of acromegaly.
Management of adrenal insufficiency during Ramadan fasting: a survey of physicians
Authors: Beshyah Salem A , Ali Khawla F , Saadi Hussein F 
Published: August 2020

Introduction:
Appropriate dose adjustments of glucocorticoids replacement therapy for adrenal insufficiency (AI) is vital.

Objective:
We sought to scope physicians’ perceptions, and practices regarding Ramadan fasting (RF) impact on the management of AI.

Methods:
A web-based survey of a convenience sample of endocrinologists.

Results:
Nearly two-thirds of 145 respondents (64.1%) were adult endocrinologists and almost half (49%) saw more than 10 hypoadrenal patients per year. Most respondents (78.6%) prescribed hydrocortisone, while the minority prescribed other preparations. The glucocorticoid doses were reportedly divided twice daily by 70.8% and thrice daily by 22.2% of respondents. Respondents recognized RF as having potential consequences in adrenal insufficiency patients included causing hypoglycaemia, undue tiredness, and fatigue, hypotension, feeling dizzy, and light-headedness. Symptoms of under-replacement were thought to happen in the late afternoon by 59.3% of respondents. Almost half (45.5%) of respondents thought that RF has some probable or definite impact on glucocorticoid therapy that certainly warrants specific concern and possible action. Three quarters (76.4%) of respondents confirmed providing specific management recommendations during RF. The most frequently reported recommendation was taking in the usual morning dose of hydrocortisone just before pre-dawn meal (Suhor) (57.8%). A third switch patients from hydrocortisone to prednisolone/prednisone. Half reported providing patients with specific recommendations regarding breaking their fast and/or seeking help if hypoadrenal symptoms occur.

Conclusions:
There is a remarkable variation in the physicians’ perceptions and practices regarding the management of AI during Ramadan. This warrants professional effort to increase the awareness and dissemination of evidence-based guidelines.
Organismal Protein Homeostasis Mechanisms
Authors: Hoppe Thorsten , Cohen Ehud 
Published: August 2020

Abstract
Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is achieved via a conserved network of quality control pathways that orchestrate the biogenesis of correctly folded proteins, prevent proteins from misfolding, and remove potentially harmful proteins by selective degradation. Nevertheless, the proteostasis network has a limited capacity and its collapse deteriorates cellular functionality and organismal viability, causing metabolic, oncological, or neurodegenerative disorders. While cell-autonomous quality control mechanisms have been described intensely, recent work on Caenorhabditis elegans has demonstrated the systemic coordination of proteostasis between distinct tissues of an organism. These findings indicate the existence of intricately balanced proteostasis networks important for integration and maintenance of the organismal proteome, opening a new door to define novel therapeutic targets for protein aggregation diseases. Here, we provide an overview of individual protein quality control pathways and the systemic coordination between central proteostatic nodes. We further provide insights into the dynamic regulation of cellular and organismal proteostasis mechanisms that integrate environmental and metabolic changes. The use of C. elegans as a model has pioneered our understanding of conserved quality control mechanisms important to safeguard the organismal proteome in health and disease.
Toma de decisiones en el sistema de salud: aportes interdisciplinarios desde la Economía de la Salud y la Ingeniería de Sistemas de Procesos
Authors: Arnaudo María Florencia , Lago Fernando Pablo , Bandoni José Alberto 
Published: August 2020

Los administradores de los sistemas de salud constantemente deben tomar decisiones referidas a su diseño y planificación, su gestión, y la evaluación de sus operaciones, entre otras. En este contexto, es necesario contar con una visión integral de los problemas, lo cual se puede lograr a partir de la conjunción de los métodos e instrumentos de la Economía de la Salud con la Ingeniería de Sistemas. El objetivo de este trabajo es reflexionar sobre las posibilidades de lograr mejoras en los sistemas de salud a partir del desarrollo del trabajo interdisciplinario entre dichas ciencias. Para ello, se exponen los objetivos de la Economía de la Salud y la Ingeniería de Sistemas de Procesos como disciplinas científicas, y se revisan algunas aplicaciones de este enfoque, que permite el diseño de herramientas para asistir en la toma de decisiones referidas a la asignación de los recursos en el sector salud. Se concluye que el modelamiento matemático, propio de la ingeniería puede ser utilizado para asesorar a los tomadores de decisiones, proporcionando información útil sobre las estrategias óptimas, teniendo en cuenta las restricciones de carácter político, presupuestarias, técnicas y de equidad propuestas por los economistas de la salud.
Identificación del grado de aislamiento en territorios insulares: caso de estudio en la provincia de Chiloé (Chile)
Authors: Rojas Zamorano Francisca , Szlafsztein Claudio Fabian 
Published: August 2020

La identificación del grado de aislamiento de un territorio insular se vuelve relevante para la gestión y planificación de un espacio geográfico. Este estudio identifica y compara el grado de aislamiento en territorios insulares. Para ello se trabajó con 10 comunas de la provincia de Chiloé (Chile), siendo estas las unidades espaciales de análisis. Se aplicó una metodología basada en la propuesta de la subdere en el 2012, cuyas variables utilizadas son la presencia de servicios públicos (educación y salud) y de conectividad (transportes y comunicación virtual). Esta metodología puede ser aplicada en otras regiones isleñas, considerando la posibilidad de requerir la incorporación de otras variables asociadas a la dimensión económica y de percepción de la población a estudiar. Como resultado, la investigación muestra que, entre las comunas analizadas, las más aisladas son Puqueldón, Curaco de Vélez, Dalcahue y Quemchi, siendo la principal variable el acceso a la conectividad. Finalmente, se determina que el aislamiento desempeña un rol importante en el desenvolvimiento de las actividades socioterritoriales de la población.Ideas destacadas: artículo de investigación que determina el grado de aislamiento de territorios insulares a una escala comunal. Compara variables relacionadas con la existencia y el acceso a los servicios de comunicación virtual, el transporte, la salud y la educación. Se identifican alrededor de 10 comunas en la provincia de Chiloé (Chile), las más aisladas son: Puqueldón, Curaco de Vélez, Dalcahue y Quemchi.
Fatores que influenciam o uso do Quadro Interativo Multimédia (QIM): Um estudo no norte de Portugal
Authors: Lopes Natália , Escola Joaquim , Raposo-Rivas Manuela 
Published: August 2020

Por força do tempo em que vivemos, é imperativo que a escola apanhe o “TGV” das Novas Tecnologias da Informação e da Comunicação, pois com elas são promovidos novos métodos e estratégias de ensino e a adaptar-se aos novos interesses/necessidades dos alunos. O Ministério da Educação português, sensível a esta nova realidade de adaptação constante aos desafios de uma sociedade tecnológica, tem feito um esforço para dotar as escolas de tecnologias adequadas aos tempos em que vivemos, nomeadamente instalando Quadros Interativos Multimédia (QIM) nas salas de aula. Neste artigo apresentam-se alguns resultados do estudo realizado sobre “o cosmos” do QIM nas escolas do ensino básico do Norte de Portugal. Seguindo uma metodologia mista, com finalidade exploratória e descritiva, o objetivo foi mostrar os fatores que estão a condicionar a integração e o uso do QIM nas salas de aula. Para isso, aplicaram-se dois questionários, um a 45 diretores e outro a 1471 professores, pertencentes a 117 agrupamentos escolares (52,94% da população). Os resultados mostram que nem a idade dos professores, nem o ano de escolaridade influenciam o uso do QIM, mas pelo contrário a disciplina que se leciona condiciona o seu uso. Conclui-se que, na perspectiva dos diretores e professores, a Matemática (75,4%), o Português (39,4%) e Estudo do Meio (28,8%) são as áreas curriculares mais adequadas para a integração curricular do QIM. Resumen: Por exigencia del momento en que vivimos, se impone que la escuela tome el “tren de alta velocidad” de las Nuevas Tecnologías de Información y Comunicación, pues con ellas se potencian nuevos métodos y estrategias de enseñanza, y a adaptarse a los nuevos intereses y necesidades del alumnado. El Ministerio de Educación portugués, sensible a esta nueva realidad de adaptación constante a los desafíos de una sociedad tecnológica, ha realizado un esfuerzo por dotar a las escuelas de tecnologías adecuadas a los tiempos en que vivimos, particularmente instalando Pizarras Digitales Interactivas (PDI) en las aulas. En este artículo, se presentan algunos resultados del estudio realizado sobre “el universo” de las PDI en las escuelas de enseñanza básica del Norte de Portugal. Con una metodología mixta y finalidad explotatoria y descriptiva, su objetivo es averiguar qué factores están condicionando la integración y uso de las PDI en las aulas. Para ello, se aplicaron dos cuestionarios a 45 directores y 1471 docentes pertenecientes a 117 agrupamientos escolares (52,94% de la población). Los resultados muestran que ni la edad de los docentes, ni el año de escolaridad influyen en el uso de la PDI; sin embargo, la materia que se imparte condiciona su uso. Se concluye que, desde la óptica de directores y dicentes, Matemáticas (75,4%), Portugués (39,4%) y Conocimiento del Medio (28,8%) son las áreas curriculares más apropiadas para la integración curricular de la PDI.
Variations in Eight Manuscript Versions of al-Kisâ'ï's Depiction of Seven Heavens
Authors: Lacináková Mária 
Published: August 2020

AbstractThis contribution presents the concept of 'seven heavens' as preserved by eight manuscripts of Muhammad ibn 'Abdallah al-Kisâ'ï's collections of Islamic religious tales Kitab A’ğāi’b al-MalakUt and Qisas al-Anbiyā It focuses on and compares the contents and composition of the chapter devoted to the topic and analyses the variations in the mss., which shed light on the way the tales are transmitted. Some of them represent variability in the original information, whereas others (including significant semantic shifts) may easily have emerged as a result of even minor scribal lapses.
Khoshut Ablai Taiji and his Fortified Monastery on the Upper Irtysh
Authors: Tsyrempilov Nikolay 
Published: August 2020

AbstractThis paper argues that until 1680s, the Oirat political culture in the upper Irtysh area was based on the leadership of Khoshut clan rather than Jungars, as it is believed nowadays. Ablai Taiji of the Khoshut nobility, the founder of the Buddhist monastery Ablai-kit, inherited and pursued a policy of cooperation with Muscovy in an attempt to profit from its trade with China. Over the course of 1670s, under pressure from his brother, Ablai lost his domains and was defeated by his enemies. To construct this narrative, this paper engages in critical analysis of diverse archival sources and existing historiography.