bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of intravenous tranexamic acid on patients undergoing shoulder arthroplasty surgery
Authors: Kissin E , Al-Tawil K , Tavakkolizadeh A , Sinha J , Colegate-Stone T 
Published: November 2020

Background Shoulder arthroplasty surgery carries the risk of blood loss. The antifibrinolytic tranexamic acid (TXA) is effective in reducing blood loss in lower limb arthroplasty. The purpose of this study was to assess blood loss and associated complications following shoulder arthroplasty performed with and without TXA for both elective and trauma indications. Methods A cohort study was performed to assess blood loss, transfusion requirements and post-operative venous thromboembolic events (VTE) following shoulder arthroplasty undertaken with and without the use of intravenous TXA. Results The study consisted of 67 patients ( n = 36 with TXA; n = 31 without TXA). Type of arthroplasty included reverse-shoulder arthroplasty, total-shoulder arthroplasty and hemiarthroplasty. There was no significant difference between TXA and non-TXA groups regarding blood loss (TXA group haemoglobin drop 20.6 mg/dL; non-TXA group haemoglobin drop 20.5 mg/dL; p = 0.978). There was no significant difference in measured outcomes with or without TXA use for elective or trauma indications, nor regarding type of arthroplasty. Discussion The use of intravenous TXA in shoulder arthroplasty was not associated with a significant reduction in blood loss or post-operative transfusion rates, nor did it impact on VTE. This result was not affected by the indication being elective or trauma nor the type of arthroplasty surgery performed.
Feasibility and Acceptability of a Community-Based Modified Mindfulness-Based Stress Reduction Program for the Under- and Unemployed
Authors: Wasson Rachel S. , Luberto Christina M. , Murthi Meera , McDonald Susan Blocksom , Pallerla Harini , Novak Brenna K. , Cotton Sian 
Published: November 2020

Background Mindfulness-Based Stress Reduction (MBSR) often improves health outcomes, though literature primarily focuses on middle-class, employed individuals. With an estimated average of six million unemployed over the past year, and the recent uptick in unemployment due to the COVID-19 pandemic, it is important to identify methods to mitigate and reduce the negative health outcomes often associated with under- and unemployment. Objectives We aimed to 1) outline the process of partnering with a community organization to implement a modified MBSR program for under- and unemployed individuals, and 2) present pilot data on preliminary results. Methods The modified MBSR program was implemented in two phases within a job training program for under- and unemployed individuals. In Phase I, group one received an eight-week program. Based on feedback, the MBSR program was reduced to six weeks and implemented for groups two and three (Phase II). Feasibility and acceptability were evaluated utilizing a mixed-methods approach. Changes in mindfulness, perceived stress, pain interference, anxiety, depression, and sleep disturbance were assessed pre-post the modified MBSR program. Results Thirty-three participants completed the program with twenty-nine post-survey responses. The modified MBSR program was feasible and acceptable as evidenced by the enrollment rate (96%), retention rate (72%), and qualitative feedback. Fifty-percent of participants self-reported weekly home practice compliance. Perceived stress and mindfulness demonstrated significant moderate improvements ( d =  .69, p =  .005; d =  .46, p =  .001). Depression, anxiety, and pain interference results suggested small non-significant effect size improvements ( d =  .27, p =  .19; d =  .23, p =  .31; d =  .25, p =  .07). Effects on fatigue and sleep disturbance were negligible. Conclusion The modified MBSR program was feasible and acceptable to the organization and participants. Small to moderate improvements in mental health and pain interference outcomes were observed. Research using larger sample sizes and randomized designs is warranted.
Contextual Support and Career Aspirations of Working Women
Authors: Kang Lakhwinder Singh , Kaur Gurpreet 
Published: November 2020

The purpose of this article was to investigate the impact of career-related support in work and non-work domains on the aspirations of women for progression in career. Using multistage sampling technique, the data were collected from 438 female employees working in private sector banks and insurance companies in Punjab, a state in north India. AMOS-based structural equation modelling was performed, and the results revealed that family/spousal support in non-work domain and supervisory and organisational support in work domain significantly predicted the career aspirations of working women, whereas the impact of collegial support was not observed. Supervisor support was found to be the most significant source of support followed by family/spousal support and then organisational support. The present study is a pioneer work, which has empirically examined the role of various forms of contextual supports in work and non-work domains in determining the desired aspirations of working women in India. The study proposes that collective efforts on the part of women themselves, their families, supervisors, colleagues and organisations are required to enhance working women’s propensity to aspire and realise their aspirations for advancement in career.
Nepheline solid solution compositions: stoichiometry revisited, reviewed, clarified and rationalised
Authors: Henderson C. Michael B. 
Published: November 2020

AbstractMolecular formulae used to recalculate nepheline analyses generally have different numbers of oxygens (e.g. NaAlSiO4(Ne), KAlSiO4,(Ks), CaAl2Si2O8(An) and SiO2(Q)). A 32 oxygen cell has 16 T cations and 8 cavity sites, but ideal nepheline stoichiometry is not necessarily followed. Ca end-member □CaCaAl2Si2O4(CaNe) and excess silica end-member □SiSi2O4(Q’) calculation requires inclusion of both vacancy species as cavity cation values. Q’ parameter calculations can involve different assumptions and four parameters are described: Qxs; QSi; Q(Si–Al); and Qcavity; these should have closely similar values for high-quality, stoichiometric analyses.Representative published compositions are recalculated to assess whether authors followed ideal nepheline stoichiometry. Phenocrysts from peralkaline rocks and nephelinites typically exhibit Al deficiencies reflected in negative Δ(Al – cavity cation) parameters (ΔAlcc), negative ‘normative’ corundum (Al2O3,Cn), and anomalously low or negative Qxsparameters; for such rock types Q(Si–Al)provides a better estimate of excess silica contents. A ΔT-site (cation charge) parameter (ΔTcharge), is closely coupled to ΔAlccand end-member NaAlSiO4has a ΔAlcc/ΔTchargeratio of 1.4296; the derivation of this value is controlled by strict stuffed-tridymite, unit-cell constraints. Natural nephelines all contain excess silica with a mean ΔAlcc/ΔTchargeof ~1.134 reflecting their Si/Al ratio being > 1.Nepheline analyses with relatively low Al and Si and high Na (also Ca) contents are common; this might reflect the presence of small amounts (up to ~5%) of cancrinite as an alteration phase or perhaps even in solid solution. The compositions of alteration lamellae of Ca-rich cancrinite in altered nepheline phenocrysts in phonolites from the Marangudzi alkaline complex, Zimbabwe, are used to define diagnostic parameters for recognising such non-stoichiometry. These alteration lamellae formed hydrothermally from Ca-rich and K-poor fluids.An EXCEL file is provided to help researchers to standardise calculation of nepheline end-member molecular proportions.
FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia
Authors: Govindarajah Vinothini , Lee Jung-Mi , Solomon Michael , Goddard Bryan , Nayak Ramesh , Nattamai Kalpana , Geiger Hartmut , Salomonis Nathan , Cancelas Jose A. , Reynaud Damien 
Published: November 2020

Abstract
Hematopoietic stem cell (HSC) activity is tightly controlled to ensure the integrity of the hematopoietic system during the organism’s lifetime. How the HSC compartment maintains its long-term fitness in conditions of chronic stresses associated with systemic metabolic disorders is poorly understood. In this study, we show that obesity functionally affects the long-term function of the most immature engrafting HSC subpopulation. We link this altered regenerative activity to the oxidative stress and the aberrant constitutive activation of the AKT signaling pathway that characterized the obese environment. In contrast, we found minor disruptions of the HSC function in obese mice at steady state, suggesting that active mechanisms could protect the HSC compartment from its disturbed environment. Consistent with this idea, we found that FOXO proteins in HSCs isolated from obese mice become insensitive to their normal upstream regulators such as AKT, even during intense oxidative stress. We established that hyperglycemia, a key condition associated with obesity, is directly responsible for the alteration of the AKT-FOXO axis in HSCs and their abnormal oxidative stress response. As a consequence, we observed that HSCs isolated from a hyperglycemic environment display enhanced resistance to oxidative stress and DNA damage. Altogether, these results indicate that chronic metabolic stresses associated with obesity and/or hyperglycemia affect the wiring of the HSCs and modify their oxidative stress response. These data suggest that the uncoupling of FOXO from its environmental regulators could be a key adaptive strategy that promotes the survival of the HSC compartment in obesity.
Efficacy and safety of carfilzomib-based regimens in frail patients with relapsed and/or refractory multiple myeloma
Authors: Facon Thierry , Niesvizky Ruben , Mateos Maria-Victoria , Siegel David , Rosenbaum Cara , Bringhen Sara , Weisel Katja , Ho P. Joy , Ludwig Heinz , Kumar Shaji , Wang Kenneth , Obreja Mihaela , Yang Zhao , Klippel Zandra , Mezzi Khalid , Goldrick Amanda , Tekle Christina , Dimopoulos Meletios A. 
Published: November 2020

Abstract
Frailty is most prevalent among elderly multiple myeloma (MM) patients, and frail patients have a higher risk of poor outcomes due to reduced performance status or comorbidities. This post hoc analysis assessed efficacy and safety of carfilzomib combinations in frail patients with relapsed and/or refractory MM from the phase 3 ASPIRE (carfilzomib [27 mg/m2]-lenalidomide-dexamethasone [KRd27] vs lenalidomide-dexamethasone [Rd]), ENDEAVOR (carfilzomib [56 mg/m2]-dexamethasone [Kd56] vs bortezomib-dexamethasone [Vd]), and ARROW (once-weekly carfilzomib [70 mg/m2]-dexamethasone [Kd70] vs carfilzomib [27 mg/m2]-dexamethasone [Kd27]) studies. A frailty algorithm incorporating age, Charlson comorbidity index, and performance status classified patients as fit, intermediate, or frail. Results are presented for frail patients (ASPIRE, n = 196; ENDEAVOR, n = 330; ARROW, n = 141). In ASPIRE, median progression-free survival (PFS) (hazard ratio; 95% confidence interval) was 24.1 (KRd27) vs 15.9 months (Rd) (0.78; 0.54-1.12); median overall survival (OS) was 36.4 vs 26.2 months (0.79; 0.57-1.08). In ENDEAVOR, median PFS was 18.7 (Kd56) vs 6.6 months (Vd) (0.50; 0.36-0.68); median OS was 33.6 vs 21.8 months (0.75; 0.56-1.00). In ARROW, median PFS was 10.3 (once-weekly Kd70) vs 6.6 months (twice-weekly Kd27) (0.76; 0.49-1.16). In all 3 studies, rates of grade ≥3 treatment-emergent adverse events were consistent with those observed in the primary studies. The ASPIRE, ENDEAVOR, and ARROW primary analyses demonstrated favorable benefit-risk profiles with carfilzomib-containing regimens compared with controls. Across clinically relevant subgroups, including those by frailty status, consistent efficacy and safety were observed with KRd27, Kd56, and weekly Kd70, and treatment with these regimens should not be restricted by frailty status.
Gender differences in question-asking at the 2019 American Society of Hematology Annual Meeting
Authors: Moazzam Saira , Onstad Lynn , O’Leary Heather , Marshall Ariela , Osunkwo Ifeyinwa , Du Emily , Dunn Tamara , Dunlap Julianne , Reed Bill , Luger Selina , Lee Stephanie J. 
Published: November 2020

Abstract
Attendance at professional conferences is an important component of career development, because conferences are a major forum for presenting new research, interacting with colleagues and networking. An extensive literature documents differences in the professional experiences of women and men, including experiences at professional conferences. We hypothesized that women are less likely than men to ask questions at conferences, thus forgoing opportunities for professional development. To address this issue, we analyzed the question-asking behavior of women and men at the 2019 Annual Meeting and Exposition of the American Society of Hematology. In all, 112 sessions (55% of those eligible) were randomly chosen for coding, yielding data on 577 presentations. Although approximately 50% of moderators and speakers were women, the proportion of questions asked by women was significantly lower compared with the estimated proportion of women attending the conference (23% vs 39%; P &lt; .0001). Women were more likely to ask questions if another woman asked the first question or if the session topic was red cells. These results suggest that although women are represented equally as moderators and speakers, they are less likely to engage in the postpresentation discourse by asking questions. Encouraging women to speak up in professional situations and providing training on question-asking skills can help address this gender gap that potentially contributes to disparities in professional visibility and career advancement for women in hematology.
Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome
Authors: Pecze Laszlo , Randi Elisa B. , Szabo Csaba 
Published: November 2020

AbstractClinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not yet been systematically reviewed. The aim of the current study was to conduct a meta-analysis of metabolites involved in bioenergetics pathways in DS to conclusively determine the difference between DS and control subjects. We discuss these findings and their potential relevance in the context of pathogenesis and experimental therapy of DS. Articles published before July 1, 2020, were identified by using the search terms “Down syndrome” and “metabolite name” or “trisomy 21” and “metabolite name”. Moreover, DS-related metabolomics studies and bioenergetics literature were also reviewed. 41 published reports and associated databases were identified, from which the descriptive information and the relevant metabolomic parameters were extracted and analyzed. Mixed effect model revealed the following changes in DS: significantly decreased ATP, CoQ10, homocysteine, serine, arginine and tyrosine; slightly decreased ADP; significantly increased uric acid, succinate, lactate and cysteine; slightly increased phosphate, pyruvate and citrate. However, the concentrations of AMP, 2,3-diphosphoglycerate, glucose, and glutamine were comparable in the DS vs. control populations. We conclude that cells of subjects with DS are in a pseudo-hypoxic state: the cellular metabolic and bio-energetic mechanisms exhibit pathophysiological alterations that resemble the cellular responses associated with hypoxia, even though the supply of the cells with oxygen is not disrupted. This fundamental alteration may be, at least in part, responsible for a variety of functional deficits associated with DS, including reduced exercise difference, impaired neurocognitive status and neurodegeneration.
Research on feeder network design: a case study of feeder service for the port of Kotka
Authors: Lin Yisong , Wang Xuefeng , Hu Hao , Zhao Hui 
Published: November 2020

Abstract
By exemplifying the feeder service for the port of Kotka, this study proposed a multi-objective optimization model for feeder network design. Innovative for difference from the single-objective evaluation system, the objective of feeder network design was proposed to include single allocation cost, intra-Europe cargo revenue, equipment balance, sailing cycle, allocation utilization, service route competitiveness, and stability. A three-stage control system was presented, and numerical experiment based on container liner’s real life data was conducted to verify the mathematical model and the control system. The numerical experiment revealed that the three-stage control system is effective and practical, and the research ideas had been applicable with satisfactory effect.
Gene flow between diploid and tetraploid junipers - two contrasting evolutionary pathways in two Juniperus populations
Authors: Farhat Perla , Siljak-Yakovlev Sonja , Valentin Nicolas , Fabregat Carlos , Lopez-Udias Silvia , Salazar-Mendias Carlos , Altarejos Joaquín , Adams Robert P. 
Published: November 2020

AbstractBackgroundGene flow and polyploidy have been found to be important inJuniperusevolution. However, little evidence has been published elucidating the association of both phenomena in juniper taxa in the wild. Two main areas were studied in Spain (Eastern Iberian Range and Sierra de Baza) with both diploid and tetraploid taxa present in sympatry. Gene flow and ploidy level were assessed for these taxa and the resulted offspring.ResultsTwenty-two allo-triploid hybrids betweenJ. sabinavar.sabinaandJ. thuriferawere found in the Eastern Iberian Range population. However, in the Sierra de Baza population no triploids were found. Instead, 18 allo-tetraploid hybrids between two tetraploid taxa:J. sabinavar.balkanensisandJ. thuriferawere discovered. High genetic diversity was exhibited among the tetraploid hybrids at Sierra de Baza, in contrast to the genetically identical triploid hybrids at the Eastern Iberian Range; this suggests meiotic difficulties within the triploid hybrids. In addition, unidirectional gene flow was observed in both studied areas.ConclusionPolyploidy and hybridization can be complementary partners in the evolution ofJuniperustaxa in sympatric occurrences.Juniperuswas shown to be an ideal coniferous model to study these two phenomena, independently or in concert.
Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age
Authors: Kok Car Reen , Brabec Bradford , Chichlowski Maciej , Harris Cheryl L. , Moore Nancy , Wampler Jennifer L. , Vanderhoof Jon , Rose Devin , Hutkins Robert 
Published: November 2020

AbstractBackgroundEarly infant feeding with intact or extensively hydrolyzed (EH) proteins or free amino acids (AA) may differentially affect intestinal microbiota composition and immune reactivity. This multicenter, double-blind, controlled, parallel-group, pilot study compared stool microbiota from Baseline (1–7 days of age) up to 60 days of age in healthy term infants who received mother’s own milk (assigned to human milk [HM] reference group) (n = 25) or were randomized to receive one of two infant formulas: AA-based (AAF;n = 25) or EH cow’s milk protein (EHF;n = 28). Stool samples were collected (Baseline, Day 30, Day 60) and 16S rRNA genes were sequenced. Alpha (Shannon, Simpson, Chao1) and beta diversity (Bray Curtis) were analyzed. Relative taxonomic enrichment and fold changes were analyzed (Wilcoxon, DESEq2). Short/branched chain fatty acids (S/BCFA) were quantified by gas chromatography. Mean S/BCFA and pH were analyzed (repeated measures ANOVA).ResultsAt baseline, alpha diversity measures were similar among all groups; however, both study formula groups were significantly higher versus the HM group by Day 60. Significant group differences in beta diversity at Day 60 were also detected, and study formula groups were compositionally more similar compared to HM. The relative abundance ofBifidobacteriumincreased over time and was significantly enriched at Day 60 in the HM group. In contrast, a significant increase in members of Firmicutes for study formula groups were detected at Day 60 along with butyrate-producing species in the EHF group. Stool pH was significantly higher in the AAF group at Days 30 and 60. Butyrate increased significantly from Baseline to Day 60 in the EHF group and was significantly higher in study formula groups vs HM at Day 60. Propionate was also significantly higher for EHF and AAF at Day 30 and AAF at Day 60 vs HM. Total and individual BCFA were higher for AAF and EHF groups vs HM through Day 60.ConclusionsDistinct patterns of early neonatal microbiome, pH, and microbial metabolites were demonstrated for infants receiving mother’s own milk compared to AA-based or extensively hydrolyzed protein formula. Providing different sources of dietary protein early in life may influence gut microbiota and metabolites.Trial registrationClinicalTrials.gov Identifier:NCT02500563. Registered July 28, 2015.
ZBTB7A functioned as an oncogene in colorectal cancer
Authors: Wang Li , Zhang Meng-Xia , Zhang Mei-Fang , Tu Zi-Wei 
Published: November 2020

AbstractBackgroundDespite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evaluate the functional roles and the clinical value of ZBTB7A in CRC progression.MethodsThe level of ZBTB7A was detected in a large cohort of CRC patients (n = 189) by immunohistochemistry (IHC), and we analyzed the diagnostic and prognostic value of the protein. In addition, the functional roles of ZBTB7A on CRC were explored in vitro and in vivo.ResultsSurvival analyses indicated that patients with high ZBTB7A expression made the prognosis worse (P = 0.024). Functionally, knockdown of ZBTB7A could markedly inhibit tumor proliferation in vitro and in vivo, whereas ZBTB7A overexpression displayed the opposite results.ConclusionsZBTB7A was associated with poor survival outcomes and functioned as an oncogene in CRC patients, indicating that it is a potential prognostic biomarker and therapeutic target for CRC patients.
Education interventions for health professionals on falls prevention in health care settings: a 10-year scoping review
Authors: Shaw L. , Kiegaldie D. , Farlie M. K. 
Published: November 2020

Abstract

Background
Falls in hospitals are a major risk to patient safety. Health professional education has the potential to be an important aspect of falls prevention interventions. This scoping review was designed to investigate the extent of falls prevention education interventions available for health professionals, and to determine the quality of reporting.

Method
A five stage scoping review process was followed based on Arksey and O’Malley’s framework and refined by the Joanna Briggs Institute Methodology for JBI Scoping Reviews. Five online databases identified papers published from January 2008 until May 2019. Papers were independently screened by two reviewers, and data extracted and analysed using a quality reporting framework.

Results
Thirty-nine publications were included. Interventions included formal methods of educational delivery (for example, didactic lectures, video presentations), interactive learning activities, experiential learning, supported learning such as coaching, and written learning material. Few studies employed comprehensive education design principles. None used a reporting framework to plan, evaluate, and document the outcomes of educational interventions.

Conclusions
Although health professional education is recognised as important for falls prevention, no uniform education design principles have been utilised in research published to date, despite commonly reported program objectives. Standardised reporting of education programs has the potential to improve the quality of clinical practice and allow studies to be compared and evaluated for effectiveness across healthcare settings.