bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional and visual responses to trypophobic images with object, animal, or human body backgrounds: an eye-tracking study
Authors: Yu Pengfei , Yu Li , Li Yuting , Qian Cheng , Hu Jia , Zhu Weiyi , Liu Fang , Wang Qi 
Published: December 2024

BackgroundTrypophobia refers to the visual discomfort (e.g., disgust or anxiety) experienced by some people when viewing clusters of bumps or holes. The spectral profile framework suggests that the spectral components of clustered patterns induces trypophobia. In contrast, the cognitive framework speculates that cognitive appraisal of dangerous objects (e.g., ectoparasites) causes trypophobia. A background effect (e.g., more disgust toward trypophobic patterns on the skin than on a desk) seems to support the cognitive framework. However, there is no study providing objective evidence for that effect and verifying these frameworks at the same time. This study aims to address that limitation by psychometric and eye-tracking experiments.MethodsWe recruited 183 participants from colleges. Initially, participants finished a personality questionnaire. The cohort then completed an eye-tracking experiment which showed the trypophobic pattern of lotus seed on three categories of background images (objects, animals and human bodies). Finally, participants rated the image’s disgust and arousal levels using a self-assessment rating scale. Meanwhile, we compared all images’ luminosity and power spectra.ResultsTrypophobic images with the human body or animal backgrounds induced a higher level of disgust and arousal than those with the object backgrounds. Participants gazed faster and dwelled longer at the trypophobic patterns on human body images than on object or animal images. Furthermore, trypophobic images with human body or animal backgrounds induced more substantial pupil dilation than those upon object backgrounds. No significant difference was detected between the power of trypophobic images with human body backgrounds and objects backgrounds. As the trypophobic images with human body backgrounds induced significant emotional or visual responses compared to those with inanimate object backgrounds. Such inconsistent results imply that the differential emotional or visual responses to trypophobic images are probably not induced by the difference in power spectra. Finally, the disgust/arousal level toward trypophobic images did not correlate with personality traits.ConclusionThese results supported the background effect of trypophobia, namely, trypophobic images with animal or human body backgrounds induce more severe disgust and cause more arousal than those with object backgrounds. Our results support the cognitive, but not spectral profile, framework of trypophobia.
Why do students drop out of regular sport in late adolescent? The experience of a systematic review
Authors: Zhang Yuancai , Wang Feng , Szakál Zsolt , Bíró Zsolt , Kovács Mátyás , Őrsi Balázs , Kovács Karolina Eszter 
Published: December 2024

IntroductionThe positive impact of youth sport on physical, mental and social health has been highlighted in several research which reinforces further investigations concerning the reasons for dropout of athletes. As one of the most emergent difficulties in youth sports is to prevent athletes from dropping out, it is important to explore what factors play important part in this process. The purpose of this study was to identify barriers and challenges related to sport persistence and dropout.MethodsWe conducted a systematic literature review using the EBSCO Discovery Service Search Engine. Our method followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsOut of the initially examined 512 publications, 11 papers were included in our final sample. Original empirical research published in a peer-reviewed journal, papers focusing on participants age below 25 years and exploring factors influencing dropout determined by any levels of Bronfenbrenner’s model were analyzed. Results showed that gender differences were extensively examined and did, in fact, contribute to dropout ratios, while socio-cultural and ethnic backgrounds were largely disregarded in most studies. From presented individual psychological factors perception of ability and success, enjoyment, sports satisfaction and life satisfaction all protected against dropout.DiscussionAchievement, goal, social and win orientation emerged as positive predictors of sport persistence in many studies, along with motivation and commitment. Many non-psychological factors were also mentioned. Sports requiring more training may lead to increased dropout rates, just as well as the lack of knowledge acquisition and competitiveness. Lastly, social environment and status also often play a significant role in dropout. Individuals with more resourceful socio-economical background find it easier to keep up the pace and have the opportunity to participate in more wealth-consuming sports. Social support received from the family and peers is a very strong preventive factor against dropout and both the personality and leadership of the coach were mentioned in multiple studies. A lack of methodological diversity, paired with the presence of only cross-sectional studies fulfilling the inclusivity criteria raises attention to the importance of examining underrepresented factors and the need for longitudinal research on the topic.Systematic review registrationhttps://inplasy.com/inplasy-2024-11-0015/, INPLASY2024110015.
Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping
Authors: Lacoste Sandrine A. , Gagnon Vanessa , Béliveau François , Lavallée Sylvie , Collin Vanessa , Hébert Josée 
Published: December 2024

Background: KMT2A rearrangements are major genetic entities in the classification of acute myeloid leukemias (AMLs), but their diverse and frequently cryptic nature makes their detection and characterization challenging. Karyotypic anomalies at the KMT2A locus and/or abnormal KMT2A Fluorescence in situ hybridization (FISH) results strongly indicate a KMT2A fusion, but the identification of the translocation partner gene often requires further investigation. KMT2A partial tandem duplications (PTDs), on the other hand, are undetectable by standard cytogenetics methods. Methods: We herein report the optical genome mapping (OGM) analysis of 38 AML samples: 12 cryptic/hard-to-characterize KMT2A fusions, 20 KMT2A-PTDs and 6 cases with no KMT2A anomaly. Results: In all the fusion cases, the rearrangement between 5’KMT2A and the 3’partner gene was identified as a translocation t(v;11q23.3)(v;118479068), and the analysis of co-occurring variants elucidated the formation of the rearrangement. The KMT2A variants detected in the KMT2A-PTD cases were surprisingly diverse. Combined with RNAseq data, OGM analysis identified 9 distinct in-frame KMT2A-PTD variants among the 20 cases analyzed. Conclusions: With the clinical development of menin inhibitors for the treatment of patients with KMT2A-rearranged acute leukemias, the characterization of these rearrangements is of utmost importance. Our results suggest that OGM is a promising tool for accurate genetic diagnosis in this context.
Chromosome-Level Genome Assembly of Discogobio brachyphysallidos (Teleostei, Cyprinidae) and Population Genomics of the D. brachyphysallidos Complex: Impacts of Geological and Climate Changes on Species Evolution in Southwest China
Authors: Zheng Lan-Ping , Wu Li-Li , Sun Hua-Ying 
Published: December 2024

The genus Discogobio is distributed in the eastern three rivers on the Yunnan–Guizhou Plateau and its adjacent regions, located to the southeast of the Qinghai–Tibet Plateau. Its origin and evolution are likely influenced by the uplift of the Qinghai-Tibet Plateau. However, the historical impact of geological events on the divergence and distribution of this fish group has not been fully elucidated. In this study, we successfully assembled a chromosome-level genome for Discogobio brachyphysallidos, which is approximately 1.21 Gb in length with a contig N50 of 8.63 Mb. The completeness of the genome assembly was assessed with a BUSCO score of 94.78%. A total of 30,597 protein-coding genes were predicted, with 93.92% functionally annotated. Phylogenetic analysis indicated that D. brachyphysallidos was closely related to Labeo rohita, and the divergence of the subfamily Labeoninae coincided with the significant uplift events of the Qinghai–Tibet Plateau. Additionally, we analyzed 75 samples of D. brachyphysallidos and D. yunnanensis from five populations, yielding 1.82 Tb of clean data and identifying 891,303,336 high-quality SNP sites. Population structure analyses indicated that the populations were clustered into five distinct groups, demonstrating significant genetic differentiation among them and the presence of cryptic species within this genus. Analyses of linkage disequilibrium decay and selective sweep indicated that the Pearl River population exhibited relatively higher genetic diversity compared with the populations from other drainages, and none of the populations showed evidence of expansion. Notably, the two population declines coincided with the early Pleistocene and Quaternary glaciation. It can be assumed that the geological movements of the Qinghai–Tibet Plateau and the Quaternary glaciation contributed to the decline in Discogobio populations and shaped their current size. The population genomics results showed that the present distribution pattern of Discogobio was the outcome of a series of geological events following the uplift of the Qinghai–Tibet Plateau. This study reconstructed the geological evolutionary history of the region from the perspective of species evolution. Furthermore, our study presents the first genome-wide analysis of the genetic divergence of Discogobio.
Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care
Authors: Gonçalves Sara , Fernandes Lisete , Caramelo Ana , Martins Maria , Rodrigues Tânia , Matos Rita S. 
Published: December 2024

Chronic pruritus, or persistent itching, is a debilitating condition that severely impacts quality of life, especially in palliative care settings. Traditional treatments often fail to provide adequate relief or are associated with significant side effects, prompting interest in alternative therapies. This review investigates the antipruritic potential of eight medicinal plants: chamomile (Matricaria chamomilla), aloe vera (Aloe barbadensis), calendula (Calendula officinalis), curcumin (Curcuma longa), lavender (Lavandula angustifolia), licorice (Glycyrrhiza glabra), peppermint (Mentha piperita), and evening primrose (Oenothera biennis). These plants are analyzed for their traditional applications, active bioactive compounds, mechanisms of action, clinical evidence, usage, dosage, and safety profiles. Comprehensive searches were conducted in databases including PubMed, Web of Science, Scopus, and b-on, focusing on in vitro, animal, and clinical studies using keywords like “plant”, “extract”, and “pruritus”. Studies were included regardless of publication date and limited to English-language articles. Findings indicate that active compounds such as polysaccharides in aloe vera, curcuminoids in turmeric, and menthol in peppermint exhibit significant anti-inflammatory, antioxidant, and immune-modulating properties. Chamomile and calendula alleviate itching through anti-inflammatory and skin-soothing effects, while lavender and licorice offer antimicrobial benefits alongside antipruritic relief. Evening primrose, rich in gamma-linolenic acid, is effective in atopic dermatitis-related itching. Despite promising preclinical and clinical results, challenges remain in standardizing dosages and formulations. The review highlights the necessity of further clinical trials to ensure efficacy and safety, advocating for integrating these botanical therapies into complementary palliative care practices. Such approaches emphasize holistic treatment, addressing chronic pruritus’s physical and emotional burden, thereby enhancing patient well-being.
Indonesia Consumer Protection Law: responding to the responsibility of automotive business actors for hidden defective products
Authors: Zakiran Asep Hakim 
Published: December 2024

The impact of globalization on the automotive industry, especially motorcycles in Indonesia, as well as the challenges faced by consumers related to defective products. With the rapid growth of the number of motorcycles, from 5 million units in 2022 to reach 6.2 million units by the end of 2023, the industry shows a significant increase in people's purchasing power. However, an accident related to a broken motorcycle frame revealed a hidden defect in the product, which triggered an investigation by the National Transportation Safety Committee (KNKT) and the Ministry of Transportation. This study uses a literature study method and applicable laws and regulations, using an analytical descriptive methodology to evaluate Aspects that can give rise to legal responsibility for business actors regarding products with hidden defects Legal Responsibility Of Business Actors For Broken ESAF Framework Which Causes Losses To Consumers according to Law Number 8 of 1999 concerning Consumer Protection (UUPK). The results show there are 2 aspects that can give legal responsibilities to producer are: Duty of care and Providing Warning and Instructure Information as consumer rights fulfilment. Furthermore, consumer protection is specifically regulated in UUPK does not specifically regulate hidden defects. In general, at Article 19 by using strict liability principle, by providing instructions and warnings, it is hoped that business actors can provide concern to consumers so that they can take better care of their goods and be free from product liability as intended in Article 27 UUPK.
Influência do consumo de cafeína no desempenho esportivo de alta performance
Authors: Sousa Camila Oliveira de , Aguiar Guilherme Rodrigues , Holanda Gustavo Moura , Honorato Filho Maurício Pereira , Marques Rossana Vanessa Dantas de Almeida 
Published: December 2024

Introdução: Os esportes de alta performance são modalidades esportivas que demandam um alto nível de habilidade e esforço dos atletas. Objetivo: Mapear os impactos do consumo exclusivo de cafeína no desempenho físico e cognitivo de atletas de elite e analisar os efeitos colaterais associados. Metodologia: Estudo de revisão integrativa realizado no segundo semestre de 2024, no qual buscou-se responder a seguinte questão-problema: “Quais as principais mudanças cognitivas e físicas induzidas pela suplementação com cafeína em atletas de elite?”. Resultados: Dentre os positivos, no desempenho físico, pode-se citar melhora na resistência e na agilidade, entre os negativos, o não melhoramento e o impacto no aspecto físico, de acordo com artigos contrários. Em relação ao desempenho cognitivo, têm-se, dentre os pontos positivos, melhora da coordenação de membros do corpo e aumento de velocidade de reação, contudo, dentre os negativos, encontra-se o aumento da insônia, ansiedade e suas crises, e nervosismo. Discussão: Entre as principais modificações após a ingestão da cafeína destacam-se alterações no desempenho de resistência, na potência e no desempenho cognitivo. Conclusão: A suplementação com cafeína aumenta efetivamente vários aspectos do desempenho esportivo de alta performance. Contudo, pode produzir diversos efeitos colaterais.
Оценка адаптивности и стрессоустойчивости сортов ярового ячменя для Волгоградской области
Authors: Питоня В.Н. , Питоня А.А. 
Published: December 2024

Валовые сборы зерна ячменя в Волгоградской области не постоянны по годам и зависят в основном от складывающихся погодных условий, которые не стабильны. Присутствуют годы как острозасушливые с повышенными температурами, так и с достаточным увлажнением. Относительно стабилизировать валовые сборы возможно за счёт создания и внедрения в производство пластичных сортов. Цель исследований: на основе анализа урожайности сортов конкурсного сортоиспытания селекции ячменя ФНЦ агроэкологии РАН за 2017 – 2021гг. по показателям вариации урожая, коэффициентам корреляции урожая с ГТК, экологической пластичности, уровню стабильности и стрессоустойчивости отобрать сорта максимально приспособленные к местным погодным условиям. Объектом исследования явились районированные и перспективные сорта ярового ячменя селекции ФНЦ агроэкологии РАН. В результате комплексной оценки выделены сорта Медикум 885, Нутанс 982, Медикум 1059 и Медикум 200, которые являются наиболее адаптивными к местным контрастным погодным условиям. Возделывание их в хозяйствах Волгоградской области позволит относительно стабилизировать валовые сборы зерна ячменя по годам.
Gross harvest of barley grain in the Volgograd region are not constant over the years and depend mainly on the prevailing weather conditions, which are not stable. There are years both acutely arid with high temperatures and with sufficient moisture. Relatively, it is possible to stabilize gross harvest by creating and introducing plastical varieties into production. The purpose of the research: select varieties that are maximally adapted to local weather conditions, based on the analysis of the yield of varieties of the competitive variety testing of barley breeding of the FSC of Agroecology RAS for 2017- 2021 according to the crop variation indicators, the coefficients of the correlation of the crop with the HTC, environmental plasticity, stability and stress resistance. The object of the study was zoned and promising varieties of spring barley selected by the FSC of Agroecology RAS. As a result of a comprehensive assessment, the varieties Medicum 885, Nutans 982, Medicum 1059 and Medicum 200 were marked, which are the most adaptive to local contrasting weather conditions. Their cultivation in the farms of the Volgograd region will make it possible to relatively stabilize the gross harvest of barley grain by years.
Оценка отобранного генофонда Pinus sylvestris L. по росту полусибсов
Authors: Иозус А.П. , Завьялов А.А. , Крючков С.Н. 
Published: December 2024

В Волгоградской области устойчивость, производительность и сохранность сосновых насаждений остается невысокой. Территория области относится к зоне сухой степи Нижнего Поволжья и располагается вне ареала естественного распространения этой породы. Основным направлением повышения устойчивости и производительности насаждений является полный перевод семеноводства сосны на селекционно-генетическую основу. Основной задачей исследования является выделение в тяжелых почвенно- климатических условиях региона комплекса наиболее эффективных приемов и методов оценки плюсовых деревьев по потомству. Впервые в сухой степи было применено разделение полусибсового потомства плюсовых деревьев сосны обыкновенной на группы по успешности роста в высоту. Исследования проводились на базе ранее созданного в регионе комплекса лесосеменных плантаций и позволили выделить наиболее эффективные селекционные приемы и особенности. Выделение среди полусибсов разных групп по успешности роста позволило определить возраст, в котором в условиях сухой степи происходит стабилизация рангов полусибсовых семей, позволяющая оценивать генетические свойства плюсовых деревьев по семенному потомству, он составил 6-10 лет. Для повышения эффективности селекционных мероприятий и биоразнообразия, необходимо вводить в селекционные программы региона отобранный и проверенный генофонд прилегающих к Волгоградской области естественных популяций сосны, в соответствии с требованиями лесосеменного районирования.
Продуктивность сортов абрикоса в условиях Волгоградской области
Authors: Никольская О.А. , Солонкин А.В. , Касьянова Г.В. 
Published: December 2024

Формирование и рост плодов проходит в постоянно изменяющихся погодных условиях, что не редко при- водит к снижению эффективности проведения агротехнологических мероприятий, направленных на по- лучение стабильных и устойчивых урожаев плодовых культур. За последние десятилетия климатические условия Волгоградской области сильно изменились, что привело к сокращению в плодовых насаждениях такой ценной культуры, как абрикос. Из-за участившихся возвратных заморозков, резких перепадов тем- пературы в дневное и ночное время, а также продолжительных оттепелей в зимний период у некоторых сортов абрикоса наблюдается гибель надземной части до 70%, а зачастую и полная гибель дерева. С целью изучения влияния метеорологических условий нашей области на плодоношение сортов абрикоса различ- ного происхождения на опытно-исследовательской территории лаборатории селекции, семеноводства и питомниководства ФНЦ агроэкологии РАН в 2015 году были высажены следующие сорта: Выносливый, Преусадебный, Полесский крупноплодный, Нью-Джерси и Мелитопольский ранний. Каждый сорт показал различный процент повреждения в результате перезимовки 2018-2022 гг. Более высокую зимостойкость и урожайность показал сорт Полесский крупноплодный, давший урожай даже в самый неурожайный год (2021 г.) – 9,3 кг плодов с одного дерева.
Как попасть в столицу царства гуннов – великолепный Варачан
Authors: Федченко О.Д. 
Published: December 2024

В статье на основе исторических свидетельств изучается расположение гуннских городов Варачан, Таргу, Чунгар, Мсндр. Комплексное изучение географических объектов, указанных в старинных документах, позволяет определить их локализацию. Исследованы свидетельства армянских, персидских и арабских историков, хронистов. Изучен маршрут миссии епископа Мец-Когманца Исраэля, который совершил переход из Барда в Варачан. Анализ упоминаемых ориентиров позволил выяснить локализацию рассматриваемых городов. Локализация городов позволяет утверждать, что «гуннское царство», о котором ведется речь в «Армянском географе», занимало территорию, которая затем называлась Кайтаг. Предложенная статья дает новый импульс для изучения археологических данных Дагестана.
Based on historical evidence, the article studies the location of the Hun cities Varachan, Targu, Chungar, Msndr. A comprehensive study of geographical objects indicated in ancient documents makes it possible to determine their localization. The testimonies of Armenian, Persian and Arab historians, chroniclers have been studied. The route of the mission of Bishop Mets-Kogmanz Israel, who made the transition from Bard to Varachan, was studied. The analysis of the mentioned landmarks made it possible to find out the localization of the cities under consideration. The localization of cities allows us to assert that the "Hunnic kingdom", which is discussed in the "Armenian Geographer", occupied the territory, which was then called Kaitag. The proposed article gives a new impetus to the study of the archaeological data of Dagestan.