bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Reconstruction of Indonesia's Mangrove Diplomacy
Authors: Robertua Verdinand 
Published: April 2020

Indonesia has the largest area of mangrove forest in the world and Indonesia has the responsibility to protect mangrove forest as part of global community in combatting greenhouse gas. However, it is still confusing the strategy in protecting Indonesia’s mangrove forest. Mangrove forest in Indonesia has been degraded rapidly due to government’s plan changing the status of mangrove forest into commercial areas. Mangrove forest has significant economic value for government and local community due to its location and woods. This research aimed to criticize government’s strategy in protecting mangrove by reconstructing Indonesia’s mangrove diplomacy. The research method is case studies of mangrove rehabilitation in Jakarta and Bali. Primary data is obtained using direct observation in Pulau Tidung Kecil, Jakarta and Bali’s mangrove forest park. This research finds that the reconstruction of Indonesia’s mangrove diplomacy need more voice from local governments, eco-business and civil society. Keywords: Mangrove forest, diplomacy, foreign policy, Indonesia ABSTRAKIndonesia memiliki hutan mangrove terluas di dunia dan Indonesia memiliki tanggung jawab untuk melindungi hutan mangrove sebagai bagian dari masyarakat dunia dalam mengatasi masalah gas rumah kaca. Permasalahan yang dihadapi adalah strategi perlindungan hutan mangrove Indonesia tidak jelas. Hutan mangrove Indonesia mengalami kerusakan sangat cepat akibat dari kebijakan Pemerintah Indonesia mengubah status hutan mangrove menjadi area komersial. Hutan mangrove memiliki nilai ekonomi yang strategis bagi masyarakat lokal dan pemerintah. Penelitian ini berusaha mengkritisi strategi pemerintah dalam melindungi hutan mangrove melalui rekonstruksi diplomasi mangrove Indonesia. Metode penelitian ini adalah metode studi kasus dengan mengambil studi rehabilitasi mangrove di Jakarta dan Bali. Data primer diperoleh dari observasi langsung di Pulau Tidung Kecil di Jakarta dan hutan mangrove di Bali. Penelitian ini berkesimpulan bahwa rekonstruksi diplomasi mangrove Indonesia perlu memerlukan peran lebih besar bagi pemerintahan lokal, bisnis hijau dan masyarakat sipil.Kata-kata kunci: Hutan mangrove, diplomasi, kebijakan luar negeri, Indonesia
Different tamponade effects of intraocular silicone oil and sterilized air after single pars plana vitrectomy for rhegmatogenous retinal detachment
Authors: Zhou Yifan , Zhang Siqi , Gao Min , Zhou Hao , Liu Haiyun , Sun Xiaodong 
Published: April 2020

Abstract
Purpose: To investigate different fundus vasculature and structure changes after single pars plana vitrectomy (PPV) following silicone oil (SO) or sterilized air in macular-off rhegmatogenous retinal detachment (RRD) patients. Method: 39 eyes (39 patients) with macular-off RRD underwent standard three-port 23-gauge PPV and intraocular SO or gas tamponade. Optical Coherence Tomography (OCT) and angiography were used to evaluate fundus structure and vasculature including retinal layers thicknesses and vessel density (VD) changes throughout observation for 12 weeks. Retinal layers were segmented into: NFL, GCL+IPL, INL, OPL, ONL+IS, OS+RPE and BRM. Fundus vasculature was segmented into superficial and deep capillary plexus (SCP, DCP), and choriocapillaris plexus (CCP). Result: For fundus vasculature, SO tamponade led to significant decrease in both SCPVD and DCPVD, while only SCPVD was found significantly decreased in gas tamponade eyes. For specific retinal layer, SO led to significant decrease in NFL and INL thicknesses. OPL, ONL+IS and OS+RPE thicknesses had significant increase in both SO tamponade and gas tamponade eyes. Conclusion: Different intraocular tamponades could have various impacts on retinal vasculature and structure. Compared to sterilized air, silicone oil tamponade could have relatively more negative effects on retinal vasculature and specific retinal layer thickness change.
Therapeutic Potential of Pluripotent Stem Cell-derived Dopaminergic Progenitors in Parkinson's Disease: A Systematic Review Protocol
Authors: Karimi Aliasghar , Elmi Mitra , Shiri Zahra , Baharvand Hossein 
Published: April 2020

Abstract
Background: Parkinson's disease (PD) is the second most common age-dependent neurodegenerative disease that causes motor and cognitive disabilities. This disease is associated with a loss of dopamine content within the putamen, which stems from the degeneration of dopaminergic (DA) neurons in the Substantia Nigra pars Compacta (SNc). Several approved drugs are available that can effectively treat symptoms of PD. However, long-term medical management is often complicated and does not delay or halt disease progression. Alternatively, cell replacement strategies can address these shortcomings and provide dopamine where it is needed. Although using human pluripotent stem cells (hPSCs) for treatment of PD is a promising alternative, no consensus in the literature pertains to efficacy concerns of hPSC-based therapy for PD. This systematic review aims to investigate the efficacy of hPSC-derived DA progenitor transplantation to treat PD in preclinical animal models.Methods: This is a systematic review of preclinical studies in animal models of PD. We intend to use the following databases as article sources: MEDLINE (via PubMed), Web of Science, and SCOPUS without any restrictions on language or publication status for all related articles published until the end of 2019. Rescue of motor deficits is defined as the primary outcome, while histological and imaging data comprise the secondary outcomes. Two independent reviewers will select the titles and abstracts, extract data from qualifying studies, and assess the risk of bias by using the SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool and the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist. The standardized mean difference (SMD) will be calculated to determine the efficacy of the treatment, with 95% confidence intervals (95% CI). The heterogeneity between studies will be calculated by "I2 inconsistency of values and Cochran's Q statistical test", where I2 > 50% and/or p < 0.10 suggest high heterogeneity. Meta-analyses of random effects will be run when appropriate.Discussion: This study will present an overview of preclinical research on hPSCs and their therapeutic effects in PD animal models. This systematic review will point out the strengths and limitations of studies in the current literature while encouraging the funding of new studies by public health managers and governmental bodies.
Serum cyfra21-1 associated with biological aggressiveness and poor prognosis in male patients with urothelial carcinoma of bladder.
Authors: Liang Haitao , Ye Yunlin , Lin Zhu , Ma Zikun , Tan Lei , Xiao Kanghua , Qin Zike 
Published: April 2020

Abstract
Background : To assess the prognostic value of preoperative serum cyfra21-1 in male patients with urothelial carcinoma of bladder treated with radical cystectomy.Methods: Patients underwent radical cystectomy from 2009-2018 at our center were retrospectively analyzed and 267 male patients met our criterions. The median follow-up was 34 months. The serum level of cyfra21-1 was measured using enzyme linked immunosorbent assay. Patients were divided into two groups (cyfra21-1≤3.30ng/ml and cyfra21-1>3.30 ng/ml). Clinical significance of cyfra21-1 level was assessed.Results: Of the 267 patients, 110 (41.2%) had normal cyfra21-1, while 157 (58.8%) had elevated serum cyfra21-1. The prevalence of lymph node involvement, locally advanced stage (≥ pT3), tumor stages, tumor size and papillary were significantly higher in patients with elevated cyfra21-1 than in those with normal cyfra21-1. Patients with high cyfra21-1 showed worse Disease free survival and Overall survival than those with low cyfra21-1 ( P = 0.001 and 0.007, respectively). In multivariate analysis, High cyfra21-1, lymph node involvement, lymphovascular invasion and papillary were independent predictors of worse Disease free survival ( P = 0.036, <0.001, 0.002, 0.014 respectively). High cyfra21-1, lymph node involvement and lymphovascular invasion were also confirmed as independent predictors of worse Overall survival ( P = 0.038, 0.010, 0.005, respectively.)Conclusions: Elevated cyfra21-1 was associated with greater biological aggressiveness and worse prognosis than normal cyfra21-1.
Repurposing naproxen as a potential antiviral agent against SARS-CoV-2
Authors: Lagzian Milad , Valadan Reza , Saeedi Majid , Roozbeh Fatemeh , Hedayatizadeh-Omran Akbar , Amanlou Massoud , Alizadeh-Navaei Reza 
Published: April 2020

Abstract
The Outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in late 2019 in China and many other countries around the world necessitate immediate action to develop new drugs against the virus. Repurposing of existing drugs for new targets is a fast, safe and unexpansive approach for this goal. Studies have shown that naproxen could specifically interact with the RNA binding domain of nueclporteins of RNA viruses such as the influenza virus. Therefore, this study aimed to evaluate the binding properties of naproxen to the nucleocapsid protein of SARS-CoV-2. 3D structure of N and C terminal domains of SARS-CoV- 2 nucleocapsid were constructed and each were docked with naproxen and analyzed during 100 ns of molecular dynamics. The results showed that naproxen interacts with the N terminal domain of the nucleocapsid via two salt bridges with Arg 88 and 92 and a network of h-bonds. Molecular dynamics analysis was also revealed that all the coordinations of naproxen with N terminal domain were kept during 100 ns of simulation time. The results of this study provide insights how naproxen can specifically interact with the conserved RNA binding module of the nucleocapsid of SARS-CoV-2 that would inhibit the packaging of viral genome into capsid and virus assembly. Therefore we recommend evaluating the antiviral effects of naproxen against SARS-CoV-2 in in vitro studies and clinical trials.
Are You Stress On Academic? Kajian Academic Workload Pada Mahasiswa yang Berperan Ganda
Authors: Faizah Faizah , Oktawiranto Randi 
Published: April 2020

Mahasiswa banyak yang mengalami stress, Sebuah penelitian yang dilakukan oleh Rahim et.al (2016) mendapatkan hasil bahwa lebih dari 80% mahasiswa mengalami stres. Hal ini dapat disebabkan beban kerja yang tinggi, seperti halnya yang disampaikan oleh Kausar (2010) & Aam et.al (2017) menunjukkan bahwa ada hubungan positif antara beban kerja dan stres akademik dengan mahasiswa. Penelitian ini bertujuan untuk mengetahui peran academic workload terhadap academic stress pada mahasiswa yang berperan ganda. Subjek merupakan mahasiswa aktif di universitas yang memiliki aktifitas lain berupa bekerja part time, subjek sebanyak 130 partisipan dengan teknik accidental sampling. Pada penelitian ini menggunakan dua instrumen penelitian yaitu Scale of academic workload (a 0.859) dan scale of academic stress (a 0.888). Analisis data menggunakan analisis data regresi linier. Hasil penelitian menunjukan terdapat pengaruh positif academic workload terhadap academic stress pada mahasiswa yang berperan ganda (R = 0.237, p<0.05).
Penyesuaian Diri Ditinjau dari Religiusitas Pada Pengguna Narkoba Di BRSKP (Balai Rehabilitasi Sosial Korban Penyalahgunaan) Napza “Insyaf” Sumatera Utara
Authors: Pangaribuan Jessica Nissi , Hartini Sri , Marpaung Winida 
Published: April 2020

ABSTRACT This study aims to find out relationship between religiosity and self adjustment. The Hypothesis of this study states that there is a positive correlation between religiosity and self adjustment, assuming that the higher religiosity, the higher will self adjustment and conversely the lower religiosity, the lower will self adjustment. The subjects of this study were 180 drug users in the BRSKP Insyaf. The data analyze used is product moment Correlation with SPSS 17 for Windows. The results of data analyze showed that the correlation coefficient was 0.390 with p 0.000 (p < 0.05). It shows that there is a positive relationship between religiosity and self adjustment. These results indicate that the contribution of a given variable of religiosity to self adjustment is at 15.2 percent, while the remaining 84.8 percent is influenced by othe factors not examined. From these results, it is concluded that the hypothesis stating that there is a positive correlation between religiosity and self adjustment is acceptable. Keywords: Self Adjustment, Religiosity, Drug Users ABSTRAK Penelitian ini bertujuan untuk mengetahui hubungan antara religiusitas dengan penyesuaian diri. Hipotesis yang diajukan dalam penelitian ini adalah ada hubungan positif antara religiusitas dengan penyesuaian diri dengan asumsi semakin tinggi religiusitas, maka semakin tinggi penyesuaian diri dan sebaliknya. Subjek penelitian yang digunakan dalam penelitian ini adalah korban penyalahgunaan narkoba di BRSKP (Balai Rehabilitasi Sosial Korban Penyalahgunaan) Napza “Insyaf” Sumatera Utara sebanyak 180 orang. Analisis data yang digunakan adalah menggunakan korelasi Product Moment melalui bantuan SPSS 17 for Windows. Hasil analisis data menunjukkan koefisien korelasi sebesar 0.390 dan nilai signifikansi sebesar 0.000 (p < 0.05). Ini menunjukkan ada hubungan positif antara religiusitas dengan penyesuaian diri. Hasil penelitian ini menunjukkan bahwa sumbangan yang diberikan variabel religiusitas terhadap penyesuaian diri sebesar 15.2 persen, selebihnya 84.8 persen dipengaruhi oleh faktor lain yang tidak diteliti. Dari hasil penelitian ini dapat disimpulkan bahwa hipotesis penelitian ada hubungan positif antara religiusitas dengan penyesuaian diri dapat diterima. Kata kunci: Penyesuaian Diri, Religiusitas , Pengguna Narkoba[1] Jessica Nissi Pangaribuan, Universitas Prima Indonesia, Email: jessicanissi31@gmail.com
Kein Digital Twin ohne digitale Durchgängigkeit
Authors: Wagner Lars 
Published: April 2020

Kurzfassung
Digital Twins bieten die Möglichkeit, das Verhalten von physischen Assets – seien es Schiffe, Autos oder Fabrikanlagen – zu simulieren, sie im laufenden Betrieb zu überwachen und durch die Rückkopplung der Betriebsdaten kontinuierlich zu verbessern. Die Daten und Modelle aus der Entwicklung bilden den Kontext, in dem die Betriebsdaten korrekt interpretiert werden können. Ihre Twin-gerechte Aufbereitung und Bereitstellung ist deshalb eine wesentliche Voraussetzung für den Einsatz von Digital-Twin-Anwendungen.
Penggunaan Metode Picture and Picture untuk Meningkatkan Keterampilan Berbicara (Materi Dongeng) pada Anak Sekolah Dasar
Authors: Rosmaya Elin 
Published: April 2020

Abstrak.Â Urutan keterampilan berbahasa yang diperoleh anak secara berurutan dimulai dari keterampilan menyimak, keterampilan berbicara, keterampilan membaca dan keterampilan menulis. Â Pada keterampilan berbicara ini, anak yang menggunakan bahasa daerah sebagai bahasa ibu merasa kesulitan berbicara menggunakan bahasa indonesia sebagai bahasa nasional dan bahasa negaranya. Kecanggungan dan rasa tidak percaya diri merupakan faktor utama anak daerah kesulitan berbicara di depan umum menggunakan bahasa Indonesia dengan memperhatikan faktor kebahasaan yang tepat. Hal ini juga menjadi permasalahan yang dikeluhkan guru SDN I dan SDN II Ciparay Kecamatan Leuwimunding kabupaten Majalengka. Untuk itu, penulis melakukan penelitian dengan judul â€œPenggunaan Metode Picture and picture untuk Meningkatkan Keterampilan Berbicara (Materi Dongeng) Pada Anak sekolah Dasar.â€ Tujuan penelitian ini adalah untuk mengetahui penggunaan metode picture and picture dalam meningkatkan keterampilan berbicara anak di kelas III dan untuk mengetahui keefektifan metode picture and picture dalam meningkatkan keterampilan berbicara anak.Â Berdasarkan penelitian, diperoleh hasil bahwa siswa yang menggunakan metode picture and picture dapat dengan mudah menceritakan kembali dan mengungkapkan pesan dongeng dibandingkan dengan yang menggunakan metode snowball throwing.Â Hal ini menunjukan bahwa metode picture and picture dapat meningkatkan kemampuan keterampilan berbicara anak SD terutama materi mengungkapkan pesan dongeng menggunakan kosakata baru dan kalimat efektif.Â Kata Kunci : Picture and picture, Keterampilan BerbicaraÂ
Impact of emergency hospital admissions on patterns of primary care prescribing: a retrospective cohort analysis of electronic records in England
Authors: Denholm Rachel , Morris Richard , Purdy Sarah , Payne Rupert 
Published: April 2020

BackgroundLittle is known about the impact of hospitalisation on prescribing in UK clinical practice.AimTo investigate whether an emergency hospital admission drives increases in polypharmacy and potentially inappropriate prescriptions (PIPs).Design and settingA retrospective cohort analysis set in primary and secondary care in England.MethodChanges in number of prescriptions and PIPs following an emergency hospital admission in 2014 (at admission and 4 weeks post-discharge), and 6 months post-discharge were calculated among 37 761 adult patients. Regression models were used to investigate changes in prescribing following an admission.ResultsEmergency attendees surviving 6 months (N= 32 657) had a mean of 4.4 (standard deviation [SD] = 4.6) prescriptions before admission, and a mean of 4.7 (SD = 4.7;P<0.001) 4 weeks after discharge. Small increases (<0.5) in the number of prescriptions at 4 weeks were observed across most hospital specialties, except for surgery (−0.02; SD = 0.65) and cardiology (2.1; SD = 2.6). The amount of PIPs increased after hospitalisation; 4.0% of patients had ≥1 PIP immediately before pre-admission, increasing to 8.0% 4 weeks post-discharge. Across hospital specialties, increases in the proportion of patients with a PIP ranged from 2.1% in obstetrics and gynaecology to 8.0% in cardiology. Patients were, on average, prescribed fewer medicines at 6 months compared with 4 weeks post-discharge (mean = 4.1; SD = 4.6;P<0.001). PIPs decreased to 5.4% (n= 1751) of patients.ConclusionPerceptions that hospitalisation is a consistent factor driving rises in polypharmacy are unfounded. Increases in prescribing post-hospitalisation reflect appropriate clinical response to acute illness, whereas decreases are more likely in patients who are multimorbid, reflecting a focus on deprescribing and medicines optimisation in these individuals. Increases in PIPs remain a concern.
Milk yield and somatic cells in dairy ewes with respect to their mutual relations
Authors: Oravcová Marta , Tvarožková Kristí­na , Tančin Vladimí­r , Uhrinčať Michal , Mačuhová Lucia 
Published: April 2020

The objective of this study was to analyze milk yield and somatic cell count (SCC) expressed as somatic cell sore (SCS) in Lacaune dairy breed. Data from milk performance testing recorded between 2016 and 2018 (farm in West Slovakia) were used. A total, 377 individual milk yield and SCC records of 61 ewes (first, second and third lacation, respectively) were analysed. Mixed model for milk yield included fixed factors: SCC class (lowest, low, middle, high and highest), year of measurement, lactation number, month in milk and interaction between month in milk and SCC class, and random factors of ewe and error. Mixed model for SCS included milk yield class (lowest, low, middle, high, highest), year of measurement, lactation number, month in milk and interaction between month in milk and milk yield class. Random factors of ewe and error were considered as well. Milk yield was significantly affected ( p <0.05 or p <0.01) by all investigated factors. Except for interaction between month in milk and milk yield class, the remaining factors significantly affected (p <0.05 or p <0.01) also SCS. The analyses confirmed that SCC may be used as a useful indicator of udder health. It may help in identifying infected ewes, and thus, avoiding mammary infections to be spread throughout the whole flock.
Comparison of settlement-era vegetation reconstructions for STEPPS and REVEALS pollen–vegetation models in the northeastern United States
Authors: Trachsel Mathias , Dawson Andria , Paciorek Christopher J. , Williams John W. , McLachlan Jason S. , Cogbill Charles V. , Foster David R. , Goring Simon J. , Jackson Stephen T. , Oswald W. Wyatt , Shuman Bryan N. 
Published: April 2020

AbstractReconstructions of prehistoric vegetation composition help establish natural baselines, variability, and trajectories of forest dynamics before and during the emergence of intensive anthropogenic land use. Pollen–vegetation models (PVMs) enable such reconstructions from fossil pollen assemblages using process-based representations of taxon-specific pollen production and dispersal. However, several PVMs and variants now exist, and the sensitivity of vegetation inferences to PVM selection, variant, and calibration domain is poorly understood. Here, we compare the reconstructions, parameter estimates, and structure of a Bayesian hierarchical PVM, STEPPS, both to observations and to REVEALS, a widely used PVM, for the pre–Euro-American settlement-era vegetation in the northeastern United States (NEUS). We also compare NEUS-based STEPPS parameter estimates to those for the upper midwestern United States (UMW). Both PVMs predict the observed macroscale patterns of vegetation composition in the NEUS; however, reconstructions of minor taxa are less accurate and predictions for some taxa differ between PVMs. These differences can be attributed to intermodel differences in structure and parameter estimates. Estimates of pollen productivity from STEPPS broadly agree with estimates produced for use in REVEALS, while comparison between pollen dispersal parameter estimates shows no significant relationship. STEPPS parameter estimates are similar between the UMW and NEUS, suggesting that STEPPS parameter estimates are transferable between floristically similar regions and scales.
Body mass index of women in Bangladesh: comparing Multiple Linear Regression and Quantile Regression
Authors: Hossain Sorif , Biswas Raaj Kishore , Hossain Md Amir 
Published: April 2020

AbstractThis study explored the association between socio-demographic factors and the body mass index (BMI) of women of reproductive age (15–49 years) in Bangladesh. Data from the 2014 Bangladesh Demographic and Health Survey (BDHS-14) were analysed using Multiple Linear Regression (MLR) and Quantile Regression (QR) analyses. The study sample comprised 15,636 non-pregnant women aged 15–49. The mean BMI of the women was 22.35±4.12 kg/m2. Over half (56.75%) had a BMI in the normal range (18<BMI<25 kg/m2), and 18.50%, 20.00% and 4.75% were underweight (BMI≤18 kg/m2), overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2), respectively. The results of the MLR found that age, wealth index, urban/rural place of residence, geographical division, womenʼs educational status, husbandʼs educational status, womenʼs working status and total number of children ever born were significantly (p<0.001) associated with respondents’ mean BMI. The QR results showed different associations between socio-demographic factors and mean BMI, as well as a different conditional distribution of mean BMI. Overall, the results indicated that women with uneducated husbands, with little or no education and from less-affluent households from rural areas tended to be more underweight compared with women in other groups. The inter-relationship between the study womenʼs mean BMI and associated socio-demographic factors was assessed using QR analysis to identify the most vulnerable cohorts of women in Bangladesh.
QUOTIENTS OF ÉTALE GROUPOIDS AND THE ABELIANIZATIONS OF GROUPOID C*-ALGEBRAS
Authors: KOMURA FUYUTA 
Published: April 2020

AbstractIn this paper, we introduce quotients of étale groupoids. Using the notion of quotients, we describe the abelianizations of groupoid C*-algebras. As another application, we obtain a simple proof that effectiveness of an étale groupoid is implied by a Cuntz–Krieger uniqueness theorem for a universal groupoid C*-algebra.