bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory Investigation on Oil Increment and Water Cut Control of CO2, N2, and Gas Mixture Huff-n-Puff in Edge-Water Fault-Block Reservoirs
Authors: Wang Peng , Zhao Fenglan , Huang Shijun , Zhang Meng , Feng Hairu , Li Yan , Song Liguang 
Published: October 2020

Abstract
Excessive water production is a common matter that seriously affects production efficiency during the development of edge-water fault-block reservoirs. Gas huff-n-puff is an effective water shutoff technology that has the characteristics of small injection volume, no interwell connectivity impact, and minor gas channeling. However, gas injection can destroy the stability of the asphaltene to induce asphaltene deposition. In this article, the laboratory experiment had been conducted to investigate the effect of injection ratio and injection sequence on oil increment and water cut control for gas mixture huff-n-puff. Experimental results indicated that the effect of N2 huff-n-puff on water cut control was the most obvious, while CO2 huff-n-puff had the best performance on oil increment. Oil increment and water cut control of gas mixture huff-n-puff with CO2 injected in advance were obviously better than that of N2 injection preferentially. Subsequently, PVTsim Nova was utilized to investigate whether reducing CO2 injection volume can inhibit asphaltene deposition and predict the possibility of asphaltene deposition at reservoir conditions. Simulation results demonstrated that the asphaltenes were easily deposited with CO2 injection while N2 injection will be unlikely to induce asphaltene deposition. Asphaltene deposition pressure envelope can qualitatively analyze the possibility of asphaltene deposition and provide a reference for screening the appropriate gas injection ratio based on giving full play to the synergistic effect of CO2 and N2. In this study, 7:3 is selected as the optimum injection ratio considering the synergistic effect and the possibility of asphaltene deposition.
Large Eddy Simulation on the Effects of Coal Particles Size on Turbulent Combustion Characteristics and NOx Formation Inside a Corner-Fired Furnace
Authors: Sun Wenjing , Zhong Wenqi , Zhang Jingzhou , Echekki Tarek 
Published: October 2020

Abstract
The effects of pulverized coal particles’ sizes on the coal combustion characteristics are numerically studied in a laboratory-scale tangentially fired furnace. The turbulent gas flow and the coal particle motion are solved by employing the large eddy simulation (LES) and the discrete phase model (DPM). The mixture fraction probability density function (MF-PDF) is coupled to simulate the non-premixed pulverized coal combustion. It is found that the coal combustion efficiency is positively affected by the dispersion of coal powders. The particle dispersion and the coal combustion are augmented by the intensive impingement caused by the corner-injected flow. Large coal particles, with their greater inertia, enhance particle agglomerations, which limit the combustion of volatile and char. Accordingly, the average flame temperature decreases with the growing particle sizes. Also, the O2 concentration increases slightly because of the incomplete coal combustion, and the CO2 concentration decreases gradually. In contrast, the CO concentration increases markedly in the furnace center due to the presence of a reducing atmosphere. The NO concentration exhibits an exponential decline with the increased particle size. A relatively stable combustion and a relatively low NOx formation are acquired inside such a corner-fired furnace when the particle Stokes number is a little greater than 1.
Optimized Pneumatic Drives Through Combined Downstream and Adaptive Upstream Throttling
Authors: Reinertz Olivier , Schmitz Katharina 
Published: October 2020

Abstract
Compressed air production is responsible for approximately 10% of the industrial electricity consumption within the European Union. Meanwhile, inefficient downstream throttling is mostly used for speed control of pneumatic drives. Thus, in the past, more efficient control strategies have been in focus of multiple research projects. Nevertheless, negative impacts of the resulting systems on simplicity in implementation and commissioning as well as on procurement costs are hindering a broader application. Therefore, the focus of this paper lies on a novel compressed air saving switching scheme, looking not for the utmost efficiency, but for simple and cheap implementation.
The solution bases on simple to implement state of the art circuits, the up- and downstream throttling. The novel system aims to combine the benefits of the two before mentioned circuits in a compact, simple to implement component. The paper presents the three before-mentioned systems and compares these by means of analytical equations and lumped parameter simulations. The study reveals a broad applicability of the novel switching scheme and significant efficiency improvements.
The integrated stress response: From mechanism to disease
Authors: Costa-Mattioli Mauro , Walter Peter 
Published: October 2020

Proteostasis dISRupted
Despite their importance, many crucial networks for protein quality control within cells diminish with age. The resulting loss of proteostasis, the process by which the health of a cell's proteins is monitored and maintained, is associated with a wide range of age-related human diseases. Costa-Mattioli and Walter review the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis. The ISR is activated in a wide range of pathological conditions, so a mechanistic understanding of its pathway may help in the development of therapeutic tools through which it can be modulated.

Science
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eaat5314
Withholding or withdrawing life-sustaining treatment in extremely low gestational age neonates
Authors: Dworetz April R , Natarajan Girija , Langer John , Kinlaw Kathy , James Jennifer R , Bidegain Margarita , Das Abhik , Poindexter Brenda , Bell Edward F , Cotten C M , Kirpalani Haresh , Shankaran Seetha , Stoll Barbara J ,   the Eunice Kennedy Shriver National Institute of Child Health
Published: October 2020

ObjectiveTo identify sociodemographic and clinical factors associated with withholding or withdrawing life-sustaining treatment (WWLST) for extremely low gestational age neonates.DesignObservational study of prospectively collected registry data from 19 National Institute of Child Health and Human Development Neonatal Research Network centres on neonates born at 22–28 weeks gestation who died >12 hours through 120 days of age during 2011–2016. Sociodemographic and clinical factors were compared between infants who died following WWLST and without WWLST.ResultsOf 1168 deaths, 67.1% occurred following WWLST. Withdrawal of assisted ventilation (97.4%) was the primary modality. WWLST rates were inversely proportional to gestational age. Life-sustaining treatment was withheld or withdrawn more often for non-Hispanic white infants than for non-Hispanic black infants (72.7% vs 60.4%; 95% CI 1.00 to 1.92) or Hispanic infants (72.7% vs 67.2%; 95% CI 1.32 to 3.72). WWLST rates varied across centres (38.6–92.6%; p<0.001). The centre with the highest rate had adjusted odds 4.89 times greater than the average (95% CI 1.18 to 20.18). The adjusted odds of WWLST were higher for infants with necrotiing enterocolitis (OR 1.77, 95% CI 1.21 to 2.59) and severe brain injury (OR 1.98, 95% CI 1.44 to 2.74).ConclusionsAmong infants who died, WWLST rates varied widely across centres and were associated with gestational age, race, ethnicity, necrotiing enterocolitis, and severe brain injury. Further exploration is needed into how race, centre, and approaches to care of infants with necrotiing enterocolitis and severe brain injury influence WWLST.
Risk of non-infectious uveitis or myasthenia gravis in patients on checkpoint inhibitors in a large healthcare claims database
Authors: Xia Tian , Brucker Alexander J , McGeehan Brendan , VanderBeek Brian L 
Published: October 2020

AimTo determine if checkpoint inhibitors (CPIs) confer an increased risk of non-infectious uveitis or myasthenia gravis (MG) compared to patients on non-checkpoint inhibitor (N-CPI) chemotherapy.MethodsA retrospective cohort study was performed comparing patients in a large commercial and Medicare advantage database exposed to CPI compared to N-CPI. All patients who initiated a CPI (ipilimumab, pembrolizumab, nivolumab, atezolizumab, avelumab, cemiplimab and durvalumab) were eligible. Date of earliest CPI in the exposure group and N-CPI chemotherapy in the comparator group was considered the index date. Exclusion occurred in both cohorts for any history of uveitis or MG diagnosis and having <1 year in the insurance plan prior to the index date, and <6 months in plan following the index date. Every exposed patient was matched up to 1:10 based on demographics and index year to patients on N-CPI chemotherapy. Multivariate Cox proportional hazards regression modelling was performed.ResultsFor evaluation of incidence of non-infectious uveitis, 26 (0.3%) of 8678 patients on CPI and 123 (0.2%) of 76 153 N-CPI comparators were found to have non-infectious uveitis. After multivariate analysis, CPIs showed an increased hazard for uveitis compared to N-CPI (HR=2.09; 95% CI 1.36 to 3.22, p=0.001). For the MG analysis, 11 (0.1%) of 9210 patients developed MG in the CPI group and 36 (0.04%) of 80 620 comparators. The CPI cohort had a higher hazard of developing MG (HR=2.60; 95% CI 1.34 to 5.07, p=0.005) compared to controls in multivariate analysis.ConclusionsExposure to CPI confers a higher risk for non-infectious uveitis and MG compared to N-CPI chemotherapy.
Outcomes of intravitreal methotrexate to salvage eyes with relapsed primary intraocular lymphoma
Authors: Mohammad Mona , Andrews Richard M , Plowman P Nicholas , Hay Gordon , Arora Amit K , Cohen Victoria M L , Sagoo Mandeep S 
Published: October 2020

PurposeTo report the outcomes of intravitreal methotrexate (MTX) injections to rescue eyes with relapsed primary intraocular lymphoma (PIOL).MethodsRetrospective case series of patients with ocular relapse of PIOL who had initially received systemic chemotherapy (all five cases) and external beam radiotherapy (EBRT) to brain and orbits (two cases). Injections of MTX (400 µg/0.1 mL) were given one time per week for 1 month, every other week for 4 months, followed by a maintenance phase of one injection one time per month for 8 months (total of 20 injections in a year).ResultsFrom April 2008 to February 2016, there were nine eyes of five patients (three men; average age at first presentation 62 years) treated with our rescue protocol of intravitreal MTX injections. Ocular relapse occurred at a mean interval of 15 months (range 5–34 months) after the completion of initial systemic treatment. At mean follow-up of 31 months (range 5–104 months), tumour control was achieved in eight out of nine eyes (89%); one eye failed, with persistent retinal infiltrates despite increasing the frequency of injections, resulting in severe keratopathy. The only other complication occurred in one eye, developing cystoid macular oedema from MTX injections that resolved with topical anti-inflammatory medications and reduced frequency of MTX. There were no cases of reduced vision or ocular relapse, but two patients died (one of central nervous system lymphoma).ConclusionsIntravitreal MTX was a safe and effective treatment modality for relapsed PIOL after systemic chemotherapy and radiotherapy, achieving local tumour control in 89%, and hence represents an optimal choice. However, given the rare nature of PIOL, larger collaborative studies with longer follow-up are needed to corroborate this.
Ten-year time trends in preterm birth during a sociodemographic transition period: a retrospective cohort study in Shenzhen, China
Authors: Ma Rui , Luo Yali , Wang Jun , Zhou Yanxia , Sun Haiyang , Ren Xi , Xu Quan , Zhang Lian , Zou Lingyun 
Published: October 2020

ObjectivesTo investigate time trends of preterm birth and estimate the contributions of risk factors to the changes in preterm birth rates over a decade (2009–2018) of transitional period in Shenzhen, China.DesignRetrospective cohort study between 2009 and 2018.SettingAll births in Baoan during January 2009 and December 2018 registered in the Shenzhen Birth Registry Database.Participants478 044 live births were included with sociodemographic and medical records for both women and infants.Outcome measuresThe incidence rate of preterm birth stratified by different maternal and infant characteristics. Multiple logistic regression was used to identify significant risk factors associated with preterm birth. The population attributable risk fraction of each factor was calculated to estimate its contribution to variations of preterm birth rate over the 10 years.ResultsA total of 27 829 preterm births from 478 044 (5.8%) live births were recorded and the preterm birth rate increased from 5.5% in 2009 to 6.2% in 2018. Medically induced preterm birth rate increased from 2.0% in 2009 to 3.4% in 2018 while spontaneous preterm labour rate decreased from 3.3% to 2.7% over the decade years. Risk factors including multiple pregnancy (0.28% increase) drove the rise of preterm birth rate, whereas changes in maternal educational attainment (0.22% reduction) and prenatal care utilisation (0.45% reduction) had contributed to the decline in preterm birth rate.ConclusionsAn uptrend of preterm birth rate was observed in an area under rapid sociodemographic transitions during 2009–2018 and the changes were associated with these sociodemographic transitions. Continued investments in girls’ education and prenatal care have the potential of reducing preterm birth rate.
(Rad 8)Caffeine prophylaxis to improve intermittent hypoxaemia in infants born late preterm: a randomised controlled dosage trial (Latte Dosage Trial)
Authors: Oliphant Elizabeth Anne , McKinlay Christopher J D , McNamara David G , Alsweiler Jane Marie 
Published: October 2020

IntroductionInfants born late preterm (34+0 to 36+6 weeks’ gestational age) have frequent episodes of intermittent hypoxaemia compared with term infants. Caffeine citrate reduces apnoea and intermittent hypoxaemia and improves long-term neurodevelopmental outcomes in infants born very preterm and may have similar effects in late preterm infants. Clearance of caffeine citrate increases with gestational age and late preterm infants are likely to need a higher dose than very preterm infants. Our aim is to determine the most effective and best-tolerated dose of caffeine citrate to reduce transient intermittent hypoxaemia events in late preterm infants.Methods and analysisA phase IIB, double-blind, five-arm, parallel, randomised controlled trial to compare the effect of four doses of oral caffeine citrate versus placebo on the frequency of intermittent hypoxaemia. Late preterm infants will be enrolled within 72 hours of birth and randomised to receive 5, 10, 15 or 20 mg/kg/day caffeine citrate or matching placebo daily until term corrected age. The frequency of intermittent hypoxaemia (events/hour where oxygen saturation concentration is ≥10% below baseline for ≤2 min) will be assessed with overnight oximetry at baseline, 2 weeks after randomisation (primary outcome) and at term corrected age. Growth will be measured at these timepoints, and effects on feeding and sleeping will be assessed by parental report. Data will be analysed using generalised linear mixed models.Ethics and disseminationThis trial has been approved by the Health and Disability Ethics Committees of New Zealand (reference 18/NTA/129) and the local institutional research review committees. Findings will be disseminated to peer-reviewed journals to clinicians and researchers at local and international conferences and to the public. The findings of the trial will inform the design of a large multicentre trial of prophylactic caffeine in late preterm infants, by indicating the most appropriate dose to use and providing information on feasibility.Trial registration numberACTRN12618001745235; Pre-results.
Osseointegrated reconstruction and rehabilitation of transtibial amputees: the Osseointegration Group of Australia surgical technique and protocol for a prospective cohort study
Authors: Haque Russel , Al-Jawazneh Shakib , Hoellwarth Jason , Akhtar Muhammad Adeel , Doshi Karan , Tan Yao Chang , Lu William Yenn-Ru , Roberts Claudia , Al Muderis Munjed 
Published: October 2020

IntroductionLower extremity amputation uniformly impairs a person’s vocational, social and recreational capacity. Rehabilitation in traditional socket prostheses (TSP) is associated with a spectrum of complications involving the socket-residuum interface which lead to reduced prosthetic use and quality of life. Osseointegration has recently emerged as a novel concept to overcome these complications by eliminating this interface and anchoring the prosthesis directly to bone. Though the complications of TSPs affect both transfemoral and transtibial amputees, Osseointegration has been predominantly performed in transfemoral ones assuming a greater benefit/risk ratio. However, as the safety of the procedure has been established, we intend to extend the concept to transtibial amputees and document the outcomes.Methods and analysisThis is protocol for a prospective cohort study, with patient enrolment started in 2014 and expected to be completed by 2022. The inclusion criteria are age over 18 years, unilateral, bilateral and mixed transtibial amputation and experiencing socket-related problems. All patients receive osseointegrated implants, the type of which depend on the length of the residuum and quality of bone, which are press-fitted into the residual bone. Objective functional outcomes comprising 6-Minute Walk Test, Timed Up-and-Go test and K-level, subjective patient-reported-quality-of-life outcomes (Short Form Health Survey 36, daily prosthetic wear hours, prosthetic wear satisfaction) and adverse events are recorded preoperatively and at postoperative follow-up intervals of 3, 6, 12 months and yearly, and compared with the preoperative values using appropriate statistical tests. Multivariable multilevel logistic regression will be performed with a focus to identify factors associated with outcomes and adverse events, specifically infection, periprosthetic fracture, implant fracture and aseptic loosening.Ethics and disseminationThe Ethics approval for the study has been received from the University of Notre Dame, Sydney, Australia (014153S). The outcomes of this study will be disseminated by publications in peer-reviewed academic journals and scientific presentations at relevant orthopaedic conferences.
Maternal age at delivery and risk of allergy and asthma in the offspring: a systematic review and meta-analysis protocol
Authors: Amera Yohannes Tesfaye , Baldeh Abdoulie K , Ali Mohamed Mustafa , Goksör Emma , Wennergren Göran , Nwaru Bright I 
Published: October 2020

IntroductionWhile several perinatal factors have been linked to the risk of developing asthma and allergy in childhood, the role of maternal age at delivery remains uncertain. Some studies suggest that young maternal age at delivery may increase the risk, while other studies suggested a reduced risk. To provide a clearer appreciation of the underlying evidence, we plan to undertake a systematic review to synthesise previous studies that have investigated the association between maternal age at delivery and the risk of asthma and allergy in the offspring.Methods and analysisWe will search PubMed, EMBASE, ISI Web of Science, Scopus and Google Scholar to identify relevant studies on the topic published in the databases from inception until October 2020. We will search databases of proceedings of international conferences, contact authors who have published on the topic and search the reference lists of the included studies in order to identify additional studies. Two investigators will independently screen the identified studies, perform data extraction and examine the risk of bias in the studies; a third investigator will arbitrate throughout these processes. We will use the Effective Public Health Practice Project tool for assessment of the risk of bias in included studies. We will perform random-effects meta-analysis to combine effect estimates from included studies judged to be homogeneous.Ethics and disseminationOnly data from the published literature will be included in this study, therefore no ethics approval is required. Our findings will be published in a peer-reviewed journal.Protocol registrationThe protocol has been submitted for registration on PROSPERO, University of York, and Centre for Review and Dissemination, now awaiting the assignment of a registration number.
External validation of the DIVA and DIVA3 clinical predictive rules to identify difficult intravenous access in paediatric patients
Authors: Girotto Cristian , Arpone Marta , Frigo Anna Chiara , Micheletto Matteo , Mazza Alessandro , Da Dalt Liviana , Bressan Silvia 
Published: October 2020

BackgroundIntravenous (IV) peripheral access is often a difficult procedure in the paediatric ED, causing pain and significant distress. Clinical prediction tools including reproducible variables have been developed to help clinicians identify children at risk of difficult IV access, likely to need additional resources/interventions to maximise success at first attempt. We aimed to externally validate the Difficult IntraVenous Access (DIVA) and DIVA3 scores developed for this purpose.MethodsCross-sectional study of children undergoing IV cannulation by nurses in a tertiary-care paediatric ED. Data were collected at the time of the procedure in a clinical report form.ResultsOf 440 children included (56.8% males; median age 4.7 years (IQR 1.5–9.5)), 23.4% had a difficult IV access (defined as requiring >1 attempt). Diagnostic accuracy measures for a DIVA cut-off ≥4 and their 95% CIs were sensitivity 24.3% (16.4% to 33.7%), specificity 92.6% (89.2% to 95.1%), positive and negative predictive value 50.0% (35.3% to 64.5%) and 80.0% (75.7% to 83.9%), respectively. The same measures for the DIVA3 were 22.3% (14.7% to 31.6%), 93.5% (90.3% to 95.9%), 51.1% (35.8% to 66.3%) and 79.8% (75.4% to 83.6%). The area under the receiver operating characteristic curve was 0.652 (95% CI 0.591 to 0.712) for the DIVA and 0.649 (95% CI 0.589 to 0.709) for the DIVA3 score. In patients with DIVA and DIVA3 <4, nurses’ prediction of greater difficulty in IV placement and moderate/severe dehydration were common independent predictors of difficult IV at multivariate analysis. Only nurses’ prediction of greater difficulty in IV placement were associated with higher odds of difficult cannulation for both DIVA/DIVA3 scores ≥4.ConclusionWe externally validated the DIVA and DIVA3 showing a similar accuracy compared with the DIVA derivation cohort and between DIVA and DIVA3. We identified factors that can help refine further the risk of difficult IV access and support decision making on the best strategy to maximise the chances of cannulation success on first attempt.