bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prompt $${J/\psi }$$-pair production at the LHC: impact of loop-induced contributions and of the colour-octet mechanism
Authors: Lansberg Jean-Philippe , Shao Hua-Sheng , Yamanaka Nodoka , Zhang Yu-Jie 
Published: December 2019

AbstractPrompt double-$$J/\psi $$J/ψ production at high-energy hadron colliders can be considered as a golden channel to probe double parton scatterings (DPS)—in particular to study gluon–gluon correlations inside the proton—and, at the same time, to measure the distribution of linearly-polarised gluons inside the proton. Such studies, however, require a good control of both single parton scatterings (SPS) and DPS in the respective regions where they are carried out. In this context, we have critically examined two mechanisms of SPS that may be kinematically enhanced where DPS are thought to be dominant, even though they are either at higher orders in the strong-coupling or velocity expansion. First, we have considered a gauge-invariant and infrared-safe subset of the loop-induced contribution via colour-singlet (CS) transitions. We have found it to become the leading CS SPS contributions at large rapidity separation, yet too small to account for the data without invoking the presence of DPS yields. Second, we have surveyed the possible colour-octet (CO) contributions using both old and up-to-date non-perturbative long-distance matrix elements (LDMEs). We have found that the pure CO yields crucially depend on the LDMEs. Among all the LDMEs we used, only two result into a visible modification of the NRQCD (CS+CO) yield, but only in two kinematical distributions measured by ATLAS, those of the rapidity separation and of the pair invariant mass. These modifications, however, do not impact the control region used for their DPS study.
Following the footsteps of giants: modeling the mobility of historically notable individuals using Wikipedia
Authors: Lucchini Lorenzo , Tonelli Sara , Lepri Bruno 
Published: December 2019

AbstractThe steady growth of digitized historical information is continuously stimulating new different approaches to the fields of Digital Humanities and Computational Social Science. In this work we use Natural Language Processing techniques to retrieve large amounts of historical information from Wikipedia. In particular, the pages of a set of historically notable individuals are processed to catch the locations and the date of people’s movements. This information is then structured in a geographical network of mobility patterns.We analyze the mobility of historically notable individuals from different perspectives to better understand the role of migrations and international collaborations in the context of innovation and cultural development. In this work, we first present some general characteristics of the dataset from a social and geographical perspective. Then, we build a spatial network of cities, and we model and quantify the tendency to explore of a set of people that can be considered as historically and culturally notable. In this framework, we show that by using a multilevel radiation model for human mobility, we are able to catch important features of migration’s behavior. Results show that the choice of the target migration place for historically and culturally relevant people is limited to a small number of locations and that it depends on the discipline a notable is interested in and on the number of opportunities she/he can find there.
Targeting Mitochondrial Fission to Trigger Cancer Cell Death
Authors: Rao V. Ashutosh 
Published: December 2019

Abstract
Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leveraged for anticancer cell killing in a heterogeneous population of cells within a tumor also remains a promising but unfulfilled premise. Toward this goal, in this issue of Cancer Research, Seo and colleagues have identified the protein complex between mitochondrial fission factor (MFF1 and MFF2) and voltage-dependent anion channel (VDAC1) as a novel regulator of mitochondrial cell death and a potential target for selective cancer cell killing.
See related article by Seo et al., p. 6215
RadioGx: A New Preclinical Tool to Model Intrinsic Radiosensitivity
Authors: Spratt Daniel E. , Speers Corey 
Published: December 2019

Abstract
Radiotherapy is perhaps the most ubiquitous single treatment modality for patients with cancer. Despite its routine use, biomarkers of treatment response are critically lacking, and the biology underlying the heterogeneity in clinical response to radiation treatment remain largely unknown. In this issue of Cancer Research, Manem and colleagues seek to change this paradigm and detail the development of a radiation response computational platform (RadioGx) that allows for the integrative analysis of radiation response using radiogenomic data derived from preclinical, in vitro sources (1). This platform holds promise for novel hypothesis generation and may allow for the discovery of novel mediators of radiation response that may improve the therapeutic efficacy of radiation. Importantly, it also moves us closer to uncovering and validating radiation response biomarkers that may prove clinically useful.
See related article by Manem et al., p. 6227
Proliferation and AKT Activity Biomarker Analyses after Capivasertib (AZD5363) Treatment of Patients with ER+ Invasive Breast Cancer (STAKT)
Authors: Robertson John F.R. , Coleman Robert E. , Cheung Kwok-Leung , Evans Abigail , Holcombe Chris , Skene Anthony , Rea Daniel , Ahmed Samreen , Jahan Ali , Horgan Kieran , Rauchhaus Petra , Littleford Roberta , Cheung S.Y. Amy , Cullberg Marie , de Bruin Elza C. , Koulai Loumpiana , Lindemann Justin P.O. , Pass Martin , Rugman Paul , Schiavon Gaia , Deb Rahul , Finlay Pauline , Foxley Andrew , Gee Julia M.W. 
Published: December 2019

Abstract

Purpose:
The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly modulate key biomarkers of the AKT pathway and tumor proliferation.

Patients and Methods:
STAKT was a two-stage, double-blind, randomized, placebo-controlled, “window-of-opportunity” study in patients with newly diagnosed ER+ invasive breast cancer. Stage 1 assessed capivasertib 480 mg b.i.d. (recommended monotherapy dose) and placebo, and stage 2 assessed capivasertib 360 and 240 mg b.i.d. Primary endpoints were changes from baseline in AKT pathway markers pPRAS40, pGSK3β, and proliferation protein Ki67. Pharmacologic and pharmacodynamic properties were analyzed from blood sampling, and tolerability by adverse-event monitoring.

Results:
After 4.5 days' exposure, capivasertib 480 mg b.i.d. (n = 17) produced significant decreases from baseline versus placebo (n = 11) in pGSK3β (H-score absolute change: −55.3, P = 0.006) and pPRAS40 (−83.8, P &lt; 0.0001), and a decrease in Ki67 (absolute change in percentage positive nuclei: −9.6%, P = 0.031). Significant changes also occurred in secondary signaling biomarker pS6 (−42.3, P = 0.004), while pAKT (and nuclear FOXO3a) also increased in accordance with capivasertib's mechanism (pAKT: 81.3, P = 0.005). At doses of 360 mg b.i.d. (n = 5) and 240 mg b.i.d. (n = 6), changes in primary and secondary biomarkers were also observed, albeit of smaller magnitude. Biomarker modulation was dose and concentration dependent, and no new safety signals were evident.

Conclusions:
Capivasertib 480 mg b.i.d. rapidly modulates key biomarkers of the AKT pathway and decreases proliferation marker Ki67, suggesting future potential as an effective therapy in AKT-dependent breast cancers.
The Quality of Pap Smears from the Brazilian Cervical Cancer Screening Program According to the Human Development Index
Authors: Costa Ricardo Filipe Alves , Longatto-Filho Adhemar , de Lima Vazquez Fabiana , Pinheiro Céline , Zeferino Luiz Carlos , Fregnani José Humberto Tavares Guerreiro 
Published: December 2019

Abstract

Brazil is a country with strong socioeconomic disparities, which may explain the different rates of cervical cancer incidence and mortality and influence the quality of cervical cancer screening tests. The aim of this study was to perform a trend analysis of some quality indicators of Pap smears according to the Municipal Human Development Index (MHDI). Information about cytopathological exams (approximately 65,000,000) performed from 2006 to 2014 in women ages 25 to 64 years was obtained from the Cervical Cancer Information System (SISCOLO). The average annual percentage change (AAPC) for each indicator was calculated using the Joinpoint Regression Program, according to MHDI levels. Very low frequencies of unsatisfactory cases (&lt;5%) were observed at different MHDI levels. Although the positivity index in the low- and medium-MHDI groups has increased, the values remained below international recommendations (3%–10%). The HSIL (high-grade squamous intraepithelial lesion) percentage remained stationary at all levels of the MHDI. In the low- and medium-MHDI groups, most quality indicators were below the recommendations by Brazilian National Cancer Institute INCA, with no improvement trend; in the high-MHDI group, the majority of the indicators also presented no improvement, although they show slightly better quality indicators. The MHDI should be considered in the definition of the policies of the screening program for cervical cancer in Brazil, and the current program may require adjustments to achieve improved efficiency.
МІЖДИСЦИПЛІНАРНА ІНТЕГРАЦІЯ ЯК КЛЮЧОВИЙ АТРИБУТ ПРОВЕДЕННЯ БІНАРНОГО ЗАНЯТТЯ
Authors: Starova Y. S. , Protsenko L. M. 
Published: December 2019

У статті запропоновано приклад проведення комплексного бінарного теоретичного заняття викладачами дисциплін «Медсестринство в анестезіології та реаніматології», «Медсестринство в хірургії» та «Основи охорони праці та охорона праці в галузі» для студентів, які навчаються за спеціальністю 223 «Медсестринство».
Trends in Outcomes of Patients With Ischemic Stroke Treated Between 2002 and 2016
Authors: Liu Junfeng , Zheng Lukai , Cheng Yajun , Zhang Shuting , Wu Bo , Wang Deren , Zhang Shihong , Tao Wendan , Wu Simiao , Liu Ming 
Published: December 2019

Background:
Little is known about long-term trends in outcomes of patients with ischemic stroke in China. We aimed to assess longitudinal trends in these outcomes over the past 15 years in China and explore possible factors behind the trends.

Methods and Results:

Patients with ischemic stroke admitted to the Department of Neurology at West China Hospital were prospectively and consecutively enrolled in a central registry since 2002, and the present study analyzed data from those admitted to hospital within 7 days of stroke during the period 2002 to 2016. Patients were binned into three 5-year intervals for temporal analysis. Death, disability, and death/disability at 3 and 12 months after stroke were compared among the time intervals across the entire sample and in subsets stratified by age (<65 or ≥65 years). To explore the possible factors related to the trends in outcomes, interaction between the factors and time on outcomes was entered separately into the multivariable logistic regression model. Of 6462 patients with ischemic stroke in the final analysis, 3837 (59.4%) were men, and mean age was 64.2 years (SD, 13.7). Mean age at stroke onset and National Institutes of Health Stroke Scale score at admission decreased significantly during the 15-year period (
P
<0.001). Between 2002 to 2006 and 2012 to 2016, cumulative incidences declined significantly for death at 3 months (from 9.6% to 6.4%), disability at 3 months (from 36.8% to 28.7%), and death/disability at 3 months (from 42.9% to 33.3%), as well as for death at 12 months (from 15.9% to 10.7%), disability at 12 months (from 23.2% to 17.6%), and death/disability at 12 months (from 35.4% to 26.4%; all
P
<0.001). The decreases in disability and death/disability at 3 and 12 months between 2002 to 2006 and 2012 to 2016 remained significant after adjusting for confounders, and the results were similar for the entire cohort and for subgroups of patients <65 or ≥65 years. Only interactions of National Institutes of Health Stroke Scale score on admission and time period (2012–2016) were found to significantly correlate with disability and death/disability at 3 and 12 months (all
P
≤0.03).

Conclusions:
Our study from a large medical center in southwest China suggests that since 2002, risks of disability and death/disability at 3 and 12 months after ischemic stroke have declined. This appears to be due, at least in part, to a significant decline in National Institutes of Health Stroke Scale score on admission, which may reflect greater public awareness of stroke detection, willingness to seek medical attention, and ease of access to healthcare infrastructure. The factors behind this apparent improvement require further study.
Episode Payments for Transcatheter and Surgical Aortic Valve Replacement
Authors: Modi Parth K. , Sukul Devraj , Oerline Mary , Thompson Michael P. , Nallamothu Brahmajee K. , Ellimoottil Chad , Shahinian Vahakn B. , Hollenbeck Brent K. 
Published: December 2019

Background:
Aortic stenosis is the most common valvular heart disease in the United States. Transcatheter aortic valve replacement (TAVR) is increasingly being adopted as an alternative to surgical aortic valve replacement (SAVR). In an era of value-based payment reform, our objective was to better understand the economic impact of the use of TAVR and SAVR in the United States.

Methods and Results:

We performed a retrospective cohort study of Medicare beneficiaries who underwent TAVR or SAVR between 2012 and 2015. Using claims from a 20% sample of national fee-for-service Medicare beneficiaries, we calculated episode payments for patients who underwent aortic valve replacement from 90 days before aortic valve replacement through 90 days after hospital discharge. Among 18 804 eligible patients, 6455 underwent TAVR (34.3%), and 12 349 underwent SAVR (65.7%). After adjustment for patient characteristics, episode payments for TAVR were ≈7% lower than for SAVR (TAVR, $55 545 [95% CI, $54 643–56 446] versus $59 467 [95% CI, $58 723–60 211];
P
<0.001). Patients with TAVR had higher preprocedural payments, but lower payments during and after the index hospitalization for the procedure. Episode payments increased with increasing comorbidity score for patients undergoing TAVR or SAVR (rate ratio, 1.16 [95% CI, 1.15–1.17];
P
<0.001); however, this association was stronger for SAVR (rate ratio, 1.18 [95% CI, 1.17–1.19]) than for TAVR (rate ratio, 1.11 [95% CI, 1.11–1.12];
P
<0.001 for interaction). Thus, differences in episode payments between TAVR and SAVR were greatest for the sickest patients but much less in healthier patients.

Conclusions:
TAVR is associated with lower episode payments than SAVR. However, episode payments for TAVR are less influenced by patient comorbidity. Therefore, as TAVR is increasingly used in patients with better baseline health status, the economic advantages of TAVR relative to SAVR may diminish.
Sensitivity of Wind Turbine Array Downstream Effects to the Parameterization Used in WRF
Authors: Shepherd T. J. , Barthelmie R. J. , Pryor S. C. 
Published: December 2019

AbstractThe Weather Research and Forecasting (WRF) Model has been extensively used for wind energy applications, and current releases include a scheme that can be applied to examine the effects of wind turbine arrays on the atmospheric flow and electricity generation from wind turbines. Herein we present a high-resolution simulation using two different wind farm parameterizations: 1) the “Fitch” parameterization that is included in WRF releases and 2) the recently developed Explicit Wake Parameterization (EWP) scheme. We compare the schemes using a single yearlong simulation for a domain centered on the highest density of current turbine deployments in the contiguous United States (Iowa). Pairwise analyses are applied to diagnose the downstream wake effects and impact of wind turbine arrays on near-surface climate conditions. On average, use of the EWP scheme results in small-magnitude wake effects within wind farm arrays and faster recovery of full WT array wakes. This in turn leads to smaller impacts on near-surface climate variables and reduced array–array interactions, which at a systemwide scale lead to summertime capacity factors (i.e., the electrical power produced relative to nameplate installed capacity) that are 2%–3% higher than those from the more commonly applied Fitch parameterization. It is currently not possible to make recommendations with regard to which wind farm parameterization exhibits higher fidelity or to draw inferences with regard to whether the relative performance may vary with prevailing climate conditions and/or wind turbine deployment configuration. However, the sensitivities documented herein to the wind farm parameterization are of sufficient magnitude to potentially influence wind turbine array siting decisions. Thus, our research findings imply high value in undertaking combined long-term high-fidelity observational studies in support of model validation and verification.
Subseasonal Forecast Skill of Snow Water Equivalent and Its Link with Temperature in Selected SubX Models
Authors: Diro G. T. , Lin H. 
Published: December 2019

AbstractAccurate and skillful subseasonal forecasts have tremendous potential for sectors that are sensitive to hazardous weather and climate events. Analysis of prediction skill for snow water equivalent (SWE) and near-surface air temperature (T2m) is carried out for three (GEPS, GEFS, and FIM) global models from the subseasonal experiment (SubX) project for the 2000–14 period. The prediction skill of SWE is higher than the skill of T2m at week-3 and week-4 lead times in all models. The GEPS forecast tends to yield higher (lower) prediction skill of SWE (T2m) compared to the other two systems in terms of correlation skill score. The snow–temperature relationship in reanalysis is characterized by a strong negative correlation over most of the midlatitude regions and a weak positive correlation over high-latitude Arctic regions. All forecast systems reproduced well these observed features; however, the snow–temperature relationship is slightly weaker in the GEPS model. Despite the apparent lack of skill in temperature forecasts at week 4, all three models are able to predict the sign of temperature anomalies associated with extreme SWE conditions albeit with reduced intensity. The strength of the predicted temperature anomaly associated with extreme snow conditions is slightly weaker in the GEPS forecast compared to reanalysis and the other two models, despite having better skill in predicting SWE. These apparent disparities suggest that weak snow–temperature coupling strength in the model is one of the contributing factors for the lower temperature skill.
Awareness of “The Real Cost” Campaign Among US Middle and High School Students: National Youth Tobacco Survey, 2017
Authors: Delahanty Janine , Ganz Ollie , Bernat Jennifer K. , Trigger Sarah , Smith Alexandria , Lavinghouze René , Rao Pamela 
Published: December 2019

Objectives: Monitoring awareness of a public education campaign can help to better understand the extent of sustained population-level exposure to the campaign. We examined unaided awareness (awareness that does not include a visual image to remind the respondent of the campaign or advertisement) and correlates of unaided awareness of “The Real Cost,” a national youth tobacco education campaign developed by the US Food and Drug Administration and implemented in 2014. Methods: This secondary analysis examined unaided campaign awareness by using data from the 2017 National Youth Tobacco Survey, a nationally representative school-based sample of young persons aged 9-19 years (n = 17 269) surveyed approximately 3 years after campaign launch. We compared unaided campaign awareness among various cigarette user groups (experimenters, susceptible nonsmokers, current or former smokers, and nonsusceptible nonsmokers). We examined associations between unaided campaign awareness and demographic and tobacco-related correlates, overall and by cigarette user group. Results: Three years after “The Real Cost” campaign was launched, most middle and high school students (58.5%) still reported unaided campaign awareness. Of 17 269 middle and high school students in the sample, 62.0% of susceptible nonsmokers and 64.5% of experimenters reported unaided campaign awareness. Among susceptible nonsmokers, unaided campaign awareness differed by age and race/ethnicity and was higher among students with greater tobacco-related harm perceptions (vs lower harm perceptions) and exposure to pro-tobacco marketing (vs no exposure). Conclusions: Future surveillance and research could examine awareness of “The Real Cost” campaign and effects of the campaign on young persons’ knowledge, attitudes, and beliefs to further assess the public health impact of tobacco prevention campaigns.
Resilience in Caregivers: A Systematic Review
Authors: Palacio G Carolina , Krikorian Alicia , Gómez-Romero María José , Limonero Joaquín T. 
Published: December 2019

Background: Resilience is a multidimensional construct that explains why people facing the consequences of adversity and stress can have a positive outcome, emphasizing adjustment to experiences that are perceived as threatening. Objective: The aim of this study is to review the construct of resilience and associated variables in caregivers of patients with chronic, advanced illness and at the end of life. Methods: The review included studies published between January 2009 and January 2019, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide reporting. The Medline, ScienceDirect, HINARI, PsychINFO, and SciELO databases were used for bibliographic exploration to identify research studies that examined the impact of resilience on adaptation and overall well-being in caregivers of patients with chronic and advanced illness. Results: A total of 23 quantitative and qualitative studies were identified whose aim was to describe the role of resilience in adaptation and coping in caregivers. In these studies, resilience was associated with a positive impact on the quality of life and emotional distress. Communication and social support increase resilient coping strategies. In most selected articles, the sampling strategy used was convenience sampling. Data collection used evaluation scales related to resilience and associated variables for quantitative studies, and semistructured interviews were used for qualitative studies. Conclusion: Promoting a resilient coping style in caregivers reduces the distress that normally results from illness-related changes in the biopsychosocial and spiritual dimensions. A resilient coping style can diminish the risk of stress and burden, and promote adaptation in the caregiver.
Negative-Pressure Wound Therapy in Foot and Ankle Surgery
Authors: Kunze Kyle N. , Hamid Kamran S. , Lee Simon , Halvorson Jason J. , Earhart Jeffrey S. , Bohl Daniel D. 
Published: December 2019

Negative Pressure Wound Therapy (NPWT) is frequently utilized to manage complex wounds, however its mechanisms of healing remain poorly understood. Changes in growth factor expression, micro- and macro-deformation, blood flow, exudate removal, and bacterial concentration within the wound bed are thought to play a role. NPWT is gaining widespread usage in foot and ankle surgery, including the management of traumatic wounds; diabetic and neuropathic ulcers; wounds left open after debridement for infection or dehiscence; high-risk, closed incisions; tissue grafts and free flaps. This article reviews the rationale for NPWT, its proposed mechanisms of action, and the evidence regarding its clinical applications within the field of foot and ankle surgery. Level of Evidence: Level V, expert opinion.