bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Antineuroinflamasi Ekstrak Etanol 96% Daun Marsilea crenata Presl. Budidaya Papda Sel Mikroglia HMC3
Authors: Maarif Burhan 
Published: December 2020

ABSTRACT
Neuroinflamation is a neurodegenerative disease caused by estrogen deficiency. Marsilea crenata Presl. is a plant that contains phytoestrogens, which are compounds that can replace the function of estrogen in maintaining cell homeostasis in the brain. The purpose of this study was to predict the antineuroinflammatory effect of 96% ethanol extract of cultivated Marsilea crenata Presl. leaves in HMC3 microglia cells through activated ER measurements, and observed using the immunocytochemistry method. IFN? is induced into cells 24 hours before treatment to cause an inflammatory condition. 96% ethanol extract of cultivated Marsilea crenata Presl. leaves is given at a dose of 62.5; 125; and 250 ?g/ml. Genistein 50 ?m was used as a positive control. The results showed that 96% ethanol extract of cultivated Marsilea crenata Presl. leaves at doses of 125 and 250 ?g/ml can decrease free ER? expression with values ??of 814,216 and 573,190 AU at p <0.05, and shows an increase in the amount of activated ER?. From these results it can be concluded that the 96% ethanol extract of cultivated Marsilea crenata Presl. leaves provides a potential antineuroinflammatory effect shown by the decreasing of free ER? expression on HMC3 microglia cells with 250 ?g/ml as the best dose.
Keywords: antineuroinflammation; ER?; phytoestrogens; Marsilea crenata Presl.; HMC3 microglia cells
ABSTRAK
Neuroinflamasi merupakan penyakit neurodegeneratif yang disebabkan defisiensi estrogen. Marsilea crenata Presl. merupakan tumbuhan yang mengandung fitoestrogen, yaitu senyawa yang dapat menggantikan fungsi estrogen dalam menjaga homeostasis sel di dalam otak. Tujuan penelitian ini adalah untuk memprediksi efek antineuroinflamasi dari ekstrak etanol 96% daun Marsilea crenata Presl. budidaya pada sel mikroglia HMC3 melalui pengukuran ER teraktivasi, dan diamati menggunakan metode immunocytochemistry. IFN? diinduksikan ke dalam sel 24 jam sebelum perlakuan untuk menimbulkan kondisi inflamasi. Ekstrak etanol 96% daun Marsilea crenata Presl. budidaya diberikan dengan dosis 62.5; 125; dan 250 ?g/ml. Genistein 50 ?m digunakan sebagai kontrol positif. Hasil menunjukkan bahwa ekstrak etanol 96% daun Marsilea crenata Presl. budidaya dengan dosis 125 dan 250 ?g/ml dapat menurunkan ekspresi ER? bebas dengan nilai 814.216 dan 573.190 AU pada p<0.05, serta menunjukkan peningkatan jumlah ER? teraktivasi. Dari hasil ini dapat disimpulkan bahwa ekstrak etanol 96% daun Marsilea crenata Presl. budidaya memberikan efek antineuroinflamasi yang potensial ditunjukkan dengan penurunan ekspresi ER? bebas pada sel mikroglia HMC3 dengan 250 ?g/ml sebagai dosis terbaik.
Kata kunci: antineuroinflamasi, ER?, fitoestrogen, Marsilea crenata Presl., sel mikroglia HMC3
ANALISIS KOMPETENSI PEDAGOGIK MAHASISWA FKIP PGSD UNIVERSITAS WIDYAGAMA MAHAKAM SAMARINDA 2018
Authors: Hermawati Desi , Handayani Eka Selvi 
Published: December 2020

Tujuan penelitian ini adalah untuk mendeskripsikan penguasaan kompetensi pedagogic mahasiswa PGSD UWGM yang di Sekolah Dasar. PenelitianÂ Â iniÂ Â merupakanÂ penelitianÂ kualitatif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara mendalam, dan dokumentasi. Sesuai dengan metode kualitatif, teknik analisis data yang digunakan adalah teknik analisis Model Miles and Huberman. Aktivitas dalam analisis ini meliputi reduksi data (data reduction), penyajian data (data display) serta Penarikan kesimpulan dan verifikasi (conclusion drawingÂ / verification). Hasil penelitian menunjukkan bahwa kompetensi pedagogik mahasiswa PGSD angkatan 2015 Universitas Widya Gama Mahakam Samarinda sangat baik yaitu sebesar 92%.
Categories of Vendian catchments – sources of fine-grained aluminosiliciclastic materials for the Serebryanka and Sylvitsa group deposits (Middle Urals)
Authors: Maslov A. V. 
Published: December 2020

Research subject. The article discusses a number of geochemical features (distribution of lanthanides and Th, values of (La/Yb)N and Eu/Eu*) of fine-grained clastic/clay rocks of various Vendian regional stages of the western slope of the Middle Urals. The results were interpreted in the context of data on the composition of the catchment areas of a number of modern rivers and information on the distribution of the same characteristics in suspended matter and modern bottom sediments of the “downstream North Dvina River–White Sea”.Methods and materials. The content of La, Sm, Eu, Gd, Yb, and Th in as many as 200 samples of shales and mudstones of the Serebryanka and Sylvitsa groups served as a research material. The research method was an analysis of the localization of individual and average data points of clayey rocks of the Laplandian, Redkinian, Belomorian and Kotlinian regional stages on paired diagrams (La/Yb)N–Eu/Eu* and (La/Yb)N–Th developed on the basis of analytical data on the composition of bottom sediments of estuarine parts of different categories/classes of modern rivers. Results. It was shown that the sedimentary sequences of the western slope of the Middle Urals are mainly composed of fine-grained clastic material belonging to categories 1 (sediments of world major rivers) and 2 (sediments of rivers draining sedimentary/mixed sedimentary formations). This material is likely to have entered the sedimentation area from the east, from the growing Kadomian Varanger-Kanin-Timan folded-thrust belt/Timan orogen, or/and from the west (Riphean sedimentary sequences of Kama-Belsk aulacogen). In addition, the igneous and metamorphic rocks of the East European Platform basement composing the structures, which could be classified as “igneous/metamorphic terranes” under modern classification, were likely to have made a certain contribution. Conclusions. The obtained results agree well with the conclusions obtained earlier as a result of mineralogical and petrographic studies of the conglomerates and sandstones of the Serebryanka and Sylvitsa groups, as well as with the data from a previous geochemical analysis of clay rocks.
The structures of the Alai and Kichi-Karakol depressions and the latest deformations in their mountainous surroundings (Southern Tien Shan)
Authors: Przhiyalgovskii E. S. , Lavrushina E. V. 
Published: December 2020

Research subject. A series of research studies was conducted in the Alai Range area, at the junction of the folded Tien Shan and Pamir provinces with the purpose of investigating the morphological structure of alpine deformations in the Paleozoic basement and Mesozoic–Cenozoic sediment cover.Materials and Methods. Structural and geological observations were carried out in the Alai and Kichi-Karakol inter-mountain depressions and their mountainous surroundings. These investigations included an analysis of the morphology and orientation of the deformation structures of the sedimentary cover and structural inconsistencies based on detailed geological mapping; measurements of the orientations of tectonic slickenlines and slickensides in the zones of active faults; processing the entire complex of data in terms of kinematic strain indicators using proven methods and calculation programs in order to determine the main parameters of the stress-strain state of the upper crustal rock complexes.Results. The age intervals and kinematic conditions of the main phases of structural transformation of the Southern Tien Shan at the Alpine stage of tectogenesis were determined based new structural and geological data, as well as materials published in previous works. It was demonstrated that, in the territory of Alai, the most significant deformations and activation of the Paleozoic basement faults occurred at the Neogene-Quarter boundary. Conclusions. At the present stage, the area under study constitutes a relatively stable block, which does not experience significant deformations associated with the encroachment of the upper crustal rock complexes of the Northern Pamir from the south.
Latitudes of the Eastern Ural microcontinent and Magnitogorsk island arc in the Paleozoic Ural Ocean
Authors: Burtman V. S. , Dvorova A. V. , Samygin S. G. 
Published: December 2020

Research subject. Rocks of the Paleozoic Eastern Ural microcontinent and Magnitogorsk island arc occupy a significant part of the Southern Urals and some part of the Middle Urals. The Western Urals are composed of rocks of the ancient Baltic continent and overthrust oceanic rocks. In the Eastern Urals and Trans-Urals rocks of the accretion complexes, oceanic crust, island arcs, the Eastern Ural microcontinent and the Kazakhstan Paleozoic continent are widespread. Rocks are exposed in the Denisov tectonic zone. The Magnitogorsk simatic Island Arc originated in the Ural Ocean, near the Baltic continent, in the early Devonian, developing from the Emsian to the Famennian. A collision between the Magnitogorsk arc and the Baltic continent occurred in the Famennian century. In the pre-Carboniferous age, the Eastern Ural microcontinent was located in the Ural Ocean. In the Tournaisian period, the Eastern Ural microcontinent accreted with the Baltic continent. The Kazakhstan continental massif was located on the other side of the Ural Ocean. The volcanic belt above the subduction zone was active on the edge of the Kazakhstan continent in the Early–Middle Devonian and in the Early Carboniferous. A subduction under the Baltic and Kazakhstan continents consumed most of the crust of the Ural Ocean by the middle of the Bashkir century. As a result, the Baltic continent (together with the Eastern Ural microcontinent) came into contact with the Kazakhstan continent. The formation of folded orogen began in the Moscow century following the collision of sialic terrains.Materials and methods. The research was based on the relevant data obtained by several researchers in 2000–2018 on rock paleomagnetism. Results. The paleolatitudinal positions of the Eastern Ural microcontinent were determined, comprising 5.3 ± 7.4°) in the Middle Ordovician and 8.2 ± 7.2° in the Early–Middle Silurian. The respective paleolatitudinal positions for the Early–Middle Devonian comprised: the Ural margin of the Baltic paleocontinent (7.7 ± 3.7°), the Magnitogorsk island arc (3.2 ± 3.1°) and the Ural margin of the Kazakhstan paleocontinent (20.6 ± 3.8°).Conclusion. According to the analysed paleomagnetic data, in the Early–Middle Devonian, the distance between the latitudes of the margins of the Baltic and Kazakhstan continents was not less than 600 km provided they were in the same hemisphere, and more than 2,300 km provided they were in different hemispheres. The convergence of the terrains was associated with the subduction of the Ural Ocean crust before its closure, which occurred in the Tournaisian century.
Deformation of the Earth’s crust: measurement methods, regularities, nature
Authors: Zubkov A. V. , Sentyabov S. V. 
Published: December 2020

Research subject. This paper investigates rock deformations and stress states in mineral excavation sites.Materials and research methods. On the basis of a 20-year geodeformational monitoring of natural stresses and deformations in the rock mass at mining sites in the Urals, carried out by the Laboratory of Geodynamics and Rock Pressure at the Institute of Geology and Geology of the Ural Branch of the Russian Academy of Sciences, we propose a novel structure of natural stress fields with reference to their change over time. Measuring instruments should be calibrated using standards of length and weight, including surveying tape measures, tapes, wires of various chemical composition, light and radio-range finders.Results. For the mining sites under study, the parameters of the variable component of stress fields with a chronological reference were determined, along with a forecast of loads both during preparatory and mining stages up to 2022. The experiments showed that, along with lithostatic (gravitational) and tectonic stresses, it is necessary to distinguish variable “astrophysical” rock stresses due to the cyclic expansion and contraction of the Earth.Conclusions. Using available measurements obtained during the most recent 11-year nanocycle of solar activity, regularities in the formation of rock deformations and stresses were revealed. A forecast of natural stresses with an increase in variable “astrophysical” stresses in the upcoming solar activity cycle was made. Measurements of rock deformations are currently performed using methods based on various physical principles. The results obtained thus far are relative, not permitting to judge about absolute values. The numerical values of dozens of fundamental physical constants are also variable. The international community of scientists should develop a mechanism to track changes in their magnitude over time.
KIRIKKALE ÜNİVERSİTESİ VETERİNER FAKÜLTESİ İKİNCİ SINIF ÖĞRENCİLERİNİN FİZYOLOJİ DERSİNE BAKIŞI VE DERSİ ANLAMA YETENEKLERİNE İLİŞKİN BİR ANKET ÇALIŞMASI
Authors: KABAKÇI Ruhi , YİĞİT Ayşe Arzu 
Published: December 2020

Amaç: Veteriner Fizyoloji dersi evcil hayvanların vücudundaki tüm yaşamsal olayların neden ve nasıl işlediğini anlatmayı konu edinmektedir. Bu çalışmada Kırıkkale Üniversitesi Veteriner Fakültesi 2. sınıf öğrencilerinin fizyoloji teorik ve uygulama derslerinin içeriğini, anlaşılma güçlüğünü ve bu güçlüklerin olası nedenlerini nasıl değerlendirdiklerini tespit etmek amaçlandı. Gereç ve Yöntemler: Toplam 129 öğrenciyle gerçekleştirilen anket altı bölümden oluşmakta olup, sorular demografik bilgiler hariç 5’li Likert tipi ölçeğe göre hazırlandı. Cronbach alfa değeri 0.83-0.94 olan anketin sonuçları tanımlayıcı ve karşılaştırmalı istatistik yöntemleriyle analiz edildi.Bulgular: Anket sonuçları, öğrencilerin fizyoloji teorik (%62.8) ve uygulama (%65.9) derslerinden memnun oldukları, teorik ders anlatımında görselliğin önemli olduğunu (%92.2), uygulamaların ise teorik konuları açıklayıcı ve tamamlayıcı nitelikte olduğunu (%62) düşündükleri gösterdi. Her ne kadar %50.4’ü fizyoloji dersini anlamakta güçlük çekmediğini belirtse de, öğrencilerin teorik derslerde sinir fizyolojisi (%39.5), uygulama derslerinde elektrokardiyografi (%26.4) konularında zorlandıkları tespit edildi. Öğrencilerin katılım oranlarına göre fizyolojinin güç anlaşılma nedenleri ise öğrenci kaynaklı, dersin kendisinden kaynaklı ve öğretim yöntemi/öğretici kaynaklı nedenler olarak sıralandığı belirlendi.Sonuç: Öğrencilerin başta zorlandıkları konular olmak üzere fizyoloji dersini daha iyi öğrenmeleri için güncel/modern eğitim tekniklerinin de eğitim-öğretim sürecine dahil edilmesi önerilebilir. Ayrıca klasik laboratuvar uygulamalarına ilaveten öğrencilerin merak, ilgi ve sorumluk bilinçlerini artırmak için vaka-temelli veya yönlendirilmiş uygulama yöntemleri de sürece dahil edilebilir.
COVİD-19’ UN NADİR PREZENTASYONU: KONJONKTİVİT VE OKÜLER TUTULUM İLE GİDEN VAKA SERİSİ
Authors: ADEMOĞLU Enis , İSLAM Mehmet Muzaffer , AKSEL Gökhan , EROĞLU Serkan Emre 
Published: December 2020

2019 yılında Çin’in Wuhan bölgesinde ortaya çıkan ve yeni tip koronavirus olarak tanımlanan Covid-19 enfeksiyonu, hızla farklı ülkelere yayılmış ve Dünya Sağlık Örgütü tarafından pandemi ilan edilmiştir. Ateş, öksürük, nefes darlığı gibi solunumsal semptomlar gösteren viral Covid-19 enfeksiyonunun oküler prezentasyonu olabileceği akla gelmektedir. Pandemi boyunca acil servisimize konjonktivit semptomları ile başvuran hastalarda Covid-19 hikayesi veya semptomlarının olması dikkatimizi çekmiştir. Bu olgu serisinde Covid-19 ilişkili akut viral konjonktivit olarak değerlendirilen 7 hasta bildirilmiştir. TC. Sağlık Bakanlığı’nın Covid-19 yönetim rehberine uygun olarak Real-time polymerase chain reaction (PCR) yöntemi ve toraks bilgisayarlı tomografisi ile tanısı doğrulanan hastalar Covid-19 ilişkili akut viral konjonktivit olarak değerlendirilmiş olup, hidroksiklorokin ve oküler antibiyoterapi tedavisi verilmiştir. Klinik olarak iyileşme sağlayan ve kontrol PCR sonucu negatif olan 7 hastanın takibi tamamlanmıştır.Özellikle pandemi döneminde bulaşın önlenmesi, doğru tanı ve tedavinin sağlanması adına Covid-19’un oküler tutulumu olup olmadığı anlaşılana kadar, konjonktivit ile başvuran hastalarda Covid-19 enfeksiyonu olabileceği akılda bulundurulmalıdır.
FROM THE WITCH TO THE FAIRY: EDNA ST. VINCENT MILLAY’S EXPLORATION OF WOMEN IN POETRY
Authors: Abril Hernández Ana 
Published: December 2020

The first decades of the twentieth century in America witnessed the emergence of one of the most famous feminist writers of that time and whose fame disappeared as rapidly as it came: Edna St. Vincent Millay (1892-1959). Her light and transgressive verse soon placed her as one of the poets that best represented the Roaring Twenties transgressing sexual and social taboos in an America dominated by the figure of the flapper that this writer perfectly embodied. This study delves into Edna St. Vincent Millay’s poetry and the representation of women in her works. Las primeras décadas del siglo veinte en Estados Unidos fueron testigos del surgimiento de una de las escritoras feministas más célebres de la época y cuya fama desapareció tan abrumadoramente como llegó: Edna St. Vincent Millay (1892-1959). Su verso ligero y transgresor pronto la situó como una de las poetas que mejor representaba los “felices años veinte” transgrediendo tabúes sexuales y sociales de una América dominada por la figura de la flapper que esta escritora encarnaba a la perfección. Este estudio profundiza en la poesía de Edna St. Vincent Millay y la representación de la mujer en sus obras.
МЕТОДОЛОГІЧНІ ПІДХОДИ ОДЕРЖАННЯ ФАКТОРА VIII ЗСІДАННЯ КРОВІ
Authors: Shurko N. O. , Novak V. L. 
Published: December 2020

The article deals with basic methods used by modern technology to obtain coagulation factor VIII (FVIII).
The blood plasma fractionation remains the only biotechnological approach to make life-saving protein therapy to treat human diseases. The biological medicines from human plasma play a vital role in the treatment of patients with different diseases. These products include a range of coagulation factors (FVIII, FIX, the prothrombin complex, Von Willebrand factor, fibrinogen etc.), immunoglobulins, protease inhibitors, anticoagulants and albumin.
Four plasma proteins are commercially important for production: albumin, IgG, factor VIII, and factor IX. VIII is a coagulation factor in the blood, which is missing or defective in patients with Hemophilia A. Replacement therapy with FVIII concentrates constitutes the basis for hemophilia care.
Cryoprecipitate was described in the mid 60's of the XX century as a first concentrate of antihemophilic FVIII.The main indications for the clinical use of cryoprecipitate were hypofibrinogenemia or disfibrinogenemia. Previously, cryoprecipitate was used for treatment of hemophilia A and von Willebrand’s disease.
Traditional FVIII production methods included deposition steps, which were aimed at elimination of protein impurities such as fibrinogen, fibronectin and immunoglobulins. These technologies could use the combination of methods at low temperatures or the addition of protein precipitating substances (PEG, polyvinylpyrrolidone, dextran, ficol, percol etc.). Using chromatographic methods in FVIII production technology allowed receiving high purity and specific activity concentrate of FVIII. Ion exchange chromatography techniques are often used in order to isolate coagulation FVIII. These techniques include methods of affinity chromatography as well as the use of monoclonal antibodies to bind of FVIII.
Nowadays, production of plasma concentrate of FVIII is used in combination with different chromatographic techniques.
НАУКОВИЙ ВНЕСОК ПРОФЕСОРА СТЕПАНА МИХАЙЛОВИЧА СТОЙКА В ПРИРОДООХОРОННУ СПРАВУ В УКРАЇНІ ТА ЄВРОПІ (ДО 100- РІЧЧЯ ВІД ДНЯ НАРОДЖЕННЯ)
Authors: Barna M. M. , Barna L. S. 
Published: December 2020

Belonging to the pleiad of eminent scientists, professor Stepan Mykhailovych Stoiko was a famous scholar with European-level reputation, a doctor of biological sciences, an honoured worker of science and technology of Ukraine, a laureate of state prize of Ukraine in science and technology, a full member of the Ukrainian Academy of Ecological Sciences, a full member of the Forest Academy of Sciences of Ukraine, an Honorary Member of the Ukrainian Botanical Society, a full member of the Shevchenko Scientific Society, Dr. Honoris Causa of Agricultural and Forestry Sciences at the Technical University in Zvolen, a Laureate of the European Peter Josef Lenne Prize for services in the field of nature protection.
The article analyzes the life’s journey and key milestones in the scientific activity of the scientist, his scientific contribution, and presents the list of biographical works.
СИСТЕМАТИЧНА, ЕКОБІОМОРФОЛОГІЧНА СТРУКТУРА ТА СОЗОЛОГІЧНА ЦІННІСТЬ ФЛОРИ ВОДНИХ І ПРИБЕРЕЖНОВОДНИХ ЕКОСИСТЕМ РІЧКИ ЗОЛОТИНКА (ЧЕРНІГІВСЬКА ОБЛАСТЬ)
Authors: Ivus Т. I. 
Published: December 2020

The results of the study of the species composition of higher aquatic and coastal-aquatic plants of the Zolotynka River within the Chernihiv region are presented. The surveyed parts of the river revealed an increase in 42 species from 33 genus and 24 families.
Small rivers serve as water storage for big rivers, they are of high ecological status which calls for improvement. One indicator of the status of small rivers is higher water and coastal-water plants, which react first to changes in the quality of the water body. By their species composition, projective cover, indicative properties and other characteristics it is possible to assess the ecological status of the river.
The study was conducted in the course of 2017–2019. The material was collected during expeditionary studies of the valley of Zolotynka river (Chernihiv district, Chernihiv region).
Zolotynka river belongs to Desna river basin and is its left tributary of the first order, its length is 13 km, the slope is 0.23 m/km, the area of the basin is 31.8 km². The river originates in the west of the village of Ivanivka, Chernihiv district of Chernihiv region. It flows southwest through the village of Zolotynka and joins Desna river.
According to the results of expeditionary field research into the flora of Zolotynka river there are 42 species of higher water and coastal-water plants belonging to 33 genus, 24 families, 3 classes (Equisetopsida, Liliopsida and Magnoliopsida) and 2 divisions (Equisetophyta and Magnoliophyta).
According to the classification of V.H. Papchenkova higher water and coastal- water flora of Zolotynka river belongs to 5 ecotypes, the largest of which is represented by a group of coastal- water plants – 27 species belonging to two ecotypes - gelophytes, or air-aquatic plants - 6 species and hygrogelophytes - 21 species.
Analysis of the areological structure showed that species with a wide range of distribution make up almost 85%, according to the structure of life forms perennial herbaceous plants make up 90%, according to K. Raunkier’s classification hemicryptophytes predominate.
According to the research findings there are 2 species that are subject to regional protection in Chernihiv region and a species recorded in the Red Data Book of Ukraine.