bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Clinical and Demographic Features of FMF with
Sacroiliitis Patients with FMF and Axial Spondyloarthritis Patients
Authors: Bayrak Esra Dilşat , Erten Sukran , Kucuksahin Orhan , Ersoy Osman 
Published: October 2020

Abstract
Objectives Familial Mediterranean fever (FMF) is the most common
autoinflammatory disease, characterised by recurrent fever and serositis
attacks lasting 1–3 days. Musculoskeletal involvement is the second
most common manifestation in FMF patients. Sacroiliitis is another
musculoskeletal involvement; as there is no spinal involvement, this is
called FMF with sacroiliitis. This study was designed to investigate the
clinical, demographic and genetic features of FMF in sacroiliitis patients
and to compare them with axial SpA and FMF patients.
Materials and Methods Forty-two FMF with sacroiliitis patients, 100
axial SpA patients and 100 FMF patients were recruited, and their
demographic characteristics were recorded. Evidence of sacroiliitis was
confirmed by sacroiliac joint MRI, and patients were examined for arthritis
and enthesitis. MEFV gene mutations, HLA B27 positivity and ESR and CRP
results were compared.
Results In the FMF with sacroiliitis group, the M694V mutation was
detected in 59.5% of patients. FMF with sacroiliitis patients were
largely (83.3%) negative for HLA B27. The frequency of enthesitis
was similar between FMF with sacroiliitis and axial SpA, and the frequency
of arthritis was higher in axial SpA patients. Inflammatory markers (ESR and
CRP) were statistically higher in FMF with sacroiliitis patients compared
with axial SpA and FMF patients.
Conclusion When all three groups were compared, the M694V mutation
was more common, HLA B27 was largely negative and inflammatory markers were
higher in the FMF with sacroiliitis group. FMF should be included in the
differential diagnosis of sacroiliitis for managing treatment correctly and
preventing complications.
An in silico study on the effect of the radionuclide half-life on PET/CT imaging with PSMA-targeting radioligands
Authors: Begum Nusrat Jihan , Glatting Gerhard , Eiber Matthias , Beer Ambros J. , Kletting Peter 
Published: October 2020

Abstract
Aim The aim of this work was to systematically investigate the influence of the radionuclide half-life and affinity of prostate-specific membrane antigen (PSMA)-targeting ligands on the activity concentration for PET/CT imaging.
Methods A whole-body physiologically-based pharmacokinetic (PBPK) model with individually estimated parameters of 13 patients with metastatic castration-resistant prostate cancer (mCRPC) was used to simulate the pharmacokinetics of PSMA-targeting radioligands. The simulations were performed with 68Ga (T1/2 = 1.13 h), 18F (T1/2 = 1.83 h), 64Cu (T1/2 = 12.7 h) and for different affinities (dissociation constants KD
of 1–0.01 nM) and a commonly used ligand amount of 3 nmol. The activity concentrations were calculated at 1, 2, 3, 4, 8, 12, and 16 h after injection.
Results The highest tumor uptake was achieved 1 h p. i. for 68Ga-PSMA. For 18F-PSMA, the highest tumor uptake was at 1 h p. i. and 2 h p.i for dissociation constants KD
= 1 nM and KD
= 0.1–0.01 nM, respectively. For 64Cu-PSMA, the highest tumor uptake was at 4 h p. i. for dissociation constant KD
= 1 nM and at 4 h p. i. (9 patients) and 8 h p. i. (4 patients) for higher affinities. Compared to 68Ga-PSMA (1 h p. i.), the activity concentrations in the tumor for 18F-PSMA (2 h p. i.) increased maximum 1.3-fold with minor differences for all affinities. For 64Cu-PSMA (4 h p. i.), the improvements were in the range of 2.8 to 3.2-fold for all affinities.
Conclusions The simulations indicate that the highest tumor-to-background ratio can be achieved after 4 hours in PET/CT using high-affinity 64Cu-PSMA.
A Palladium-Free Sonogashira Coupling Protocol Employing an In Situ Prepared Copper/Chelating 1,2,3-Triazolylidene System
Authors: Sarkar Biprajit , Vougioukalakis Georgios C. , Tonis Efstathios , Stein Felix , Stamatopoulos Ioannis K. , Stubbe Jessica , Zarkadoulas Athanasios 
Published: October 2020

AbstractA new, palladium-free Sonogashira coupling reaction protocol using a catalytic system that comprises a simple, cheap, widely available copper salt and a chelating 1,2,3-triazolylidene ligand precursor is reported. This protocol provides the desired coupling products in moderate to very good yields.
Total Synthesis of Surinamensinols A and B
Authors: Al-Harrasi Ahmed , Avula Satya Kumar , Das Biswanath , Csuk Rene , Al-Rawahi Ahmed 
Published: October 2020

AbstractAn efficient total synthesis of the naturally occurring anti-inflammatory and antitumour 8-O-4′-neolignans, surinamensinols A and B, has been accomplished from commercially available allyl alcohol and (S)-ethyl lactate. The synthetic sequence involves a palladium-catalysed Suzuki–Miyaura cross-coupling reaction followed by a chiral Mitsunobu­ reaction as the key steps. This is the first report of the simultaneous stereoselective total synthesis of surinamensinols A and B through a single approach involving only six steps.
Clinical Profile of Episodic Wheezing and Multiple Trigger Wheezing in Preschool Children: A Cross-Sectional Study
Authors: Tualzik Lalsiama , Chandrasekaran Venkatesh 
Published: October 2020

AbstractThe objectives of our study were to identify the relative frequency of episodic viral wheeze (EVW) and multiple trigger wheeze (MTW) in preschool children of 1 to 5 years of age with recurrent wheezing and to compare the relevant clinical and sociodemographic parameters in the above phenotypes. This cross-sectional study included 165 children aged 1 to 5 years with recurrent wheeze. Participants were categorized into EVW and MTW based on history according to European Respiratory Society Task Force recommendations 2008. Symptom control was assessed by Global Initiative for Asthma guidelines 2015. Of the total participants, EVW was seen in 55% and MTW in 45%. Children with MTW were significantly older than those with EVW, more atopic, and had higher eosinophil counts. The dominant phenotype seen in our study was EVW. The absence of ocular/nasal allergy and exclusive breastfeeding predicted well-controlled symptoms in EVW and in all preschool wheezers, respectively.
Effect of the Extent of Resection on Survival Outcome in Glioblastoma: Propensity Score Approach
Authors: Tunthanathip Thara , Madteng Suphavadee 
Published: October 2020

AbstractObjective To evaluate the effectiveness of the extent of resection (EOR) on survival outcome using propensity score-based approaches.Materials and Methods A retrospective cohort study was performed in patients with newly diagnosed glioblastoma. Propensity score matching (PSM) and propensity score regression adjustment were used in the matched and unmatched dataset, respectively. Therefore, the Kaplan-Meier survival curve and Cox's regression analyses were performed to determine the effect of the EOR on survival outcomes.Results One hundred and sixty-eight patients were included for analyzes. The total tumor resection in the unmatched dataset was 22.6% of all cases. Using PSM, incomplete tumor resection had an unfavorable survival outcome when compared with total tumor resection (hazard ratio (HR) 2.92, 95% confidence interval [CI] 1.72–4.94). Additionally, biopsy and partial tumor resection were significantly associated with poor prognosis when compared with total tumor resection using propensity score regression adjustment (HR of biopsy 1.89, 95%CI 1.13–3.16 and HR of partial resection 1.89, 95%CI 1.28–2.80).Conclusions Patients with total tumor resection tend to have a more favorable prognosis than patients with partial tumor resection. The propensity score-based analysis is an alternative approach to evaluate the effect of an intervention that has limitations to perform a randomized controlled trial.
Remarkable Clinical Improvement Following Microsurgical Resection of Left Lingual Gyrus Cerebral Cavernous Malformation: A Case Report
Authors: Hoz Samer S. , Al-Sharshahi Zahraa F. , Altaweel Mustafa M. , Albanaa Saja A. 
Published: October 2020

Abstract
Introduction Cerebral cavernous malformations (CCMs) are collections of dilated and irregular capillaries in the brain. Cerebral cavernous malformations are predominantly supratentorial; occipital CCMs are rare. Surgical removal is indicated for CCMs with recurrent hemorrhage, refractory seizures, and expanding lesions.
Case Description We describe a case of a 15-year-old male who presented with repeated tonic-clonic seizures and right homonymous hemianopia of 3-week duration. Magnetic resonance imaging (MRI) showed a mass located on the left medial occipital lobe, specifically in the left lingual gyrus. The T2-weighted and T2-gradient echo images confirmed the diagnosis of a CCM. Total microscopic resection was achieved. There were no surgical complications. The visual deficit improved, and the patient was seizure-free on subsequent follow-up visits.
Conclusion Surgical resection of an occipital CCM resulted in a remarkable improvement in terms of seizures and visual field deficits.
Nonketotic Hyperglycemic Chorea in a 10-Year-Old Asian Boy with Diabetes Mellitus
Authors: Marian Julia , Rizvi Firdous , Lew Lily Q. 
Published: October 2020

AbstractNonketotic hyperglycemic chorea-ballism (NKHCB), also known as diabetic striato-pathy (DS) by some, is a rare complication of diabetes mellitus and uncommon in children. We reported a case of a 10 11/12-year-old male child of Asian descent with uncontrolled type 1 diabetes mellitus (T1DM), Hashimoto's thyroiditis, and multiple food allergies presenting with bilateral chorea-ballism. His brain magnetic resonance imaging revealed developmental venous anomaly in right parietal lobe and right cerebellum, no focal lesions or abnormal enhancements. Choreiform movements resolved with correction of hyperglycemia. Children and adolescents with a movement disorder should be evaluated for diabetes mellitus, especially with increasing prevalence and insidious nature of T2DM associated with obesity.
Association between Childhood Allergic Diseases and Headache
Authors: Charoensanti Sudarat , Uthaisangsook Suwannee , Padsee Nadda , Srisingh Klaita 
Published: October 2020

AbstractAllergic disorders and headache are both common in pediatric populations. Chronic allergic disorders may affect sleep leading to chronic daily headaches. Poor controlled allergies may cause neurogenic inflammation that may be a predisposing factor to migraine headaches. We hypothesized that a higher prevalence of headaches may be found in children with allergy compared with those without allergy. Patients with either multiple allergic disorders or with poorly controlled allergic symptoms may be associated with headaches, especially migraine headaches. This study aimed to examine (1) the prevalence of headache in allergic children and (2) the association between allergic diseases and headache. Patients with allergic diseases and nonallergic children as control were recruited in the pediatric outpatient clinic of Naresuan University Hospital between January 2017 and January 2018. A neurological examination was performed by a pediatric neurologist. The questionnaire consisted of the pediatric headache symptom checklist and the items for evaluation of allergy control status. The diagnosis and classification of headache were based on the International Classification of Headache Disorders-3 criteria. The results were analyzed using the Student's t-test, chi-squared tests, odds ratios, and 95% confidence interval. One hundred fifty-five subjects were enrolled in our study, of which 85 subjects (54.8%) were diagnosed with allergic diseases. The allergic group had a significantly higher prevalence of headache than the control group (37 [43.5%] vs. 19 [27.1%], p = 0.035). The allergic group also had a significantly higher prevalence of migraine and probable migraine headache than the control group (23 [27.06%] vs. 7 [10%], p = 0.007). The prevalence of headache did not increase in subjects who had more than one allergic disease. There was no association between the control of allergy and headache. The present study showed that allergic diseases were associated with increased prevalence of headache and migraine in children. However, the control of allergic symptoms and the number of allergic diseases were not associated with headache. The physicians should be aware of headache in allergic patients and give appropriate treatment. Further study would be to identify specific biomarkers for the development of better treatment in these comorbid diseases.
Comorbidities in Patients with COVID-19 and Their Impact on the Severity of the Disease
Authors: Bashir Shahid , Moneeba Sadaf , Alghamdi Alaa , Alghamdi Fouad , Niaz Asim , Anan Hadeel , Kaleem Imdad 
Published: October 2020

AbstractInfection with COVID-19 is associated with significant morbidity, especially in patients with chronic medical conditions. At least one-fifth of cases require supportive care in intensive care units, which have limited availability in most developing countries. A literature search was conducted on PubMed, Medline, Scopus, Embase, and Google Scholar to find articles published by May 7, 2020 on the role of comorbidities in patients with COVID-19 and the impact of comorbidities on the disease. This review highlighted that patients with comorbidities are more likely to experience severe disease than those with no other conditions; that is, comorbidities correlated with greater disease severity in patients with COVID-19. Proper screening of COVID-19 patients should include careful inquiries into their medical history; this will help healthcare providers identify patients who are more likely to develop serious disease or experience adverse outcomes. Better protection should also be given to patients with COVID-19 and comorbidities upon confirmation of the diagnosis. This literature review showed that the comorbidities most often associated with more severe cases of COVID-19 are hypertension, cardiovascular disease, and diabetes. Individuals with these comorbidities should adopt restrictive measures to prevent exposure to COVID-19, given their higher risk of severe disease.
Needs and Satisfiers: A Tool for Dealing with Perspectivity in Policy Analysis
Authors: Mahlert Bettina 
Published: October 2020

AbstractThe concept of basic human needs can be employed for avoiding a danger that arises from the perspectivity of development knowledge, namely, the use of overly narrowing cognitive and evaluative frameworks that obscure relevant contextual realities. Drawing on existing literatures, the paper proposes to use three features of needs satisfiers as a tool for discovering such narrowing effects: (a) satisfiers for the same needs vary across groups and over time; (b) a candidate satisfier can enable or hamper the fulfillment of a need, depending on which other potential satisfiers it connects with; (c) a satisfier can simultaneously fulfill some needs and fail to fulfill other needs, and this holds both for the needs of one person and of different groups. In order to illustrate, the paper analyses three development reports, addressing needs for food and physical security as well as identity and recognition, and taking African land-tenure regimes as empirical example.
Study of the effect of super-atom dephasing on Rydberg blockade in thermal vapor
Authors: Kara Dushmanta , Mohapatra Ashok K 
Published: October 2020

Abstract
We present a theoretical model with a large number of interacting atoms that can be used to study the Rydberg blockade in thermal vapor. Exact calculations for two, three and four interacting atoms are extrapolated to formulate the model for N interacting atoms using the method of induction. The effect of the decay mechanisms such as the laser frequency noise and the super-atom dephasing arising due to the relative motion of the atoms on the blockade processes are discussed. We show that with large laser frequency noise the blockade effect vanishes. However, in the presence of large super-atom dephasing, the blockade effect does not vanish completely which suggests that the blockade can be observed in the thermal vapor system.
Non-destructive evaluation of pipes by microwave techniques and artificial neural networks
Authors: Xie Yi , Yang Xiaoqing , Yuan Jianping , Zhu Zhanxia 
Published: October 2020

Abstract
Near-field imaging based on an electromagnetic sensor has been widely used for nondestructive detection. An approach to detect the near-surface defects in pipeline coatings and dielectric pipelines is proposed. Based on the characteristics of resonant frequency shifts, a novel method using artificial neural network (ANN) is established to quantitatively evaluate circular-section shape defects in pipes, such as air bubbles in pipeline coating layers or qualitative characterize non-circular section-shape defects. The proposed method has three important modules: a new resonator for data acquisition, a signal-processing algorithm for data preprocessing, and an ANN for quantitative imaging. In the designed sensor, we extend the tip of the sensing ring and introduce an appending in the ring gap for high sensitivity. Simulations show that the sensor can detect a defect with a radius as small as 0.7 mm. The raw resonant frequency shifts obtained by the sensor scanning at an angle interval around the specimen first are preprocessed by curve fitting, sampling, and adaptive data interpolation or truncation. Then, using an ANN, the relationships among resonant frequency shifts, external radius of the specimen, and defect size are modeled for imaging of circular-section shape defects. Preliminary simulations and measurements illustrate the efficacy of the method. Consequently, a contactless, high-resolution, near-field imaging measurement based on sensor scanning for inspecting pipe structures is obtained.
Mott barrier behavior of metal–TlGaSe2 layered semiconductor junction
Authors: Kandemir Buket Bilgen , Gören Serdar , Erdem Mehmet , Cengiz Asuman , Şale Yasin , Fedotov Aleksander K , Mammadov Tofig G , Seyidov MirHasan Yu 
Published: October 2020

Abstract
We report on the characteristics of metal-p-type high resistance TlGaSe2 semiconductor junction barrier fabricated by deposition of indium and gold metals. The electrical properties of /TlGaSe2/ semiconductor contacts were monitored as a function of temperature in the range of ∼80–300 K using current–voltage (

I
−
V

) and capacitance–voltage (

C
−
V

) measurements. Device characteristics of

I
n

/TlGaSe2/

A
u

showed rectification properties. From forward bias

I
−
V

characteristics it was revealed that the increase of current is slower than the predictions by Schottky barrier theory. The rectification properties of

I
n

/TlGaSe2/

A
u

semiconductor device were simulated by the Mott barrier model where the presence of an undoped layer on the semiconductor surface is assumed, and measurements and computational simulation agreed on the validity of this model.

C
−
V

measurements showed that at higher temperatures

I
n

/TlGaSe2/

A
u

barrier showed a capacitance from accumulation toward depletion mode, whereas at low temperatures the barrier capacitance degradation was found. The observed

C
−
V

of

I
n

/TlGaSe2/

A
u

does not significantly change over the entire bias range

±

30 V, confirming that the

I
n

/TlGaSe2/

A
u

is fully depleted, thus the structures are Mott barrier.
First-principles electronic band diagram calculations showed that introduction of

S
e

-atom vacancies in the various sites of TlGaSe2 unit cell greatly affects the electronic band structure of this semiconductor in an increasing manner in band gaps with respect to stoichiometric compound. Consequently, the

S
e

- vacancies localized inside the thin surface layer of TlGaSe2 are responsible for high average surface electrical resistivity of the material and could be proposed as a physical basis for the existence of native insulator layer on TlGaSe2 surface. Thus we propose a model for TlGaSe2 crystal which is comprised from an electrically conducting bulk semiconductor sandwiched between two high resistivity thin surface sheets. We suggest that the selenium vacancy defects on the surface of TlGaSe2 layered semiconductor are also responsible for the memristive behavior of this compound.
Low-temperature processed high-performance visible–transparent Ga2O3 solar blind ultraviolet photodetectors with the indium–tin–oxide electrode
Authors: Li Zhe , Xu Yu , Cheng Yaolin , Zhang Jiaqi , Chen Dazheng , Yao Danyang , Feng Qian , Xu Shengrui , Zhang Jincheng , Zhang Chunfu , Hao Yue 
Published: October 2020

Abstract
High-performance visible–transparent electronics are being used as emerging technologies in next-generation ‘see-through’ devices. In this work, the high-performance fully visible–transparent metal–semiconductor-metal (MSM) interdigitated Ga2O3 solar blind ultraviolet (UV) photodetector (PD) was successfully fabricated by using the ITO electrode. The Ga2O3 film and the ITO electrode were grown on the sapphire substrate by the radio frequency magnetron sputtering method at a low temperature. It is demonstrated that the Ga2O3 film is the single crystal film with the (−201) crystal plane orientation, and its bandgap can be obtained around 4.8 eV. Compared with the control tradsitional opaque PD with the Ti/Au metal electrode, the fully visible–transparent solar blind UV PD with the ITO electrode showed a larger photocurrent of 1.8 µA and responsivity of 181.03 A W−1 at the bias voltage of 20 V. The external quantum efficiency (EQE) even reached 88 198%, and photo-to-dark current ratio achieved 4.8 × 105. Besides, the PD with the ITO electrode also had a shorter response time and good electrical stability after multiple light cycles. The fabricated fully visible–transparent Ga2O3 solar blind UV PD is among the best reported Ga2O3 UV PDs and shows the great potential for the next generation of ‘see-through’ functional devices.
Investigation of heavy-ion strikes on a fin field-effect transistor-based low-noise amplifier
Authors: Rajendiran P , Nagarajan K K , Srinivasan R 
Published: October 2020

Abstract
The consequences of heavy-ion strikes on a fin field-effect transistor-based low-noise amplifier (LNA) are analyzed in this paper. A popular LNA topology, cascoded LNA, is selected to study the single-event effect using numerical device simulation. A heavy-ion strike resulting in a current pulse (known as a single-event transient) disturbs the LNA output. These disturbances are analyzed in the time and frequency domains. The collected charge (Q
C) is used as a metric in the time domain, and the spurious frequencies generated are investigated in the frequency domain. This study is performed using four different LNA operating frequencies, 10 GHz, 30 GHz, 60 GHz, and 77 GHz. It is found that for a given dose of radiation, the performance of the LNA operating at the lowest frequency, i.e. 10 GHz, suffers the most from the radiation strike.
Flat limit of the de Sitter QFT in the rest frame vacuum
Authors: Cotăescu Ion I. 
Published: October 2020

Abstract
The problem of the flat limits of the scalar and spinor fields on the de Sitter expanding universe is considered in the traditional adiabatic vacuum and in the new rest frame vacuum we proposed recently, in which the frequencies are separated in the rest frames as in special relativity. It is shown that only in the rest frame vacuum can the Minkowskian flat limit be reached naturally for any momentum, whereas in the adiabatic vacuum, this limit remains undefined in rest frames in which the momentum vanishes. An important role is played by the phases of the fundamental solutions in the rest frame vacuum, which must be regularized to obtain the desired Minkowskian flat limits. This procedure fixes the phases of the scalar mode functions and Dirac spinors, resulting in their definitive expressions derived here. The physical consequence is that, in the rest frame vacuum, the flat limits of the one-particle operators are simply the corresponding operators of special relativity.