bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mock juror's perceptions of a child witness passing or failing a truth and lies discussion or promising to tell the truth
Authors: O'Connell Felicity , Cherryman Julie , Warmelink Lara 
Published: October 2019

SummaryThis study examined the effect of a child passing or failing the UK truth and lies discussion (TLD) compared with the Canadian promise to tell the truth on mock jurors' decisions regarding witness credibility and truthfulness and defendant guilt. Ninety‐two participants read a vignette that described a child witnessing his father physically attacking his mother. The vignette was manipulated for witness age (age 4 years and age 8 years) and TLD performance/promise. Supporting the hypotheses, participants rated the witness's credibility and truthfulness significantly higher after a witness passed a TLD and after promising to tell the truth. The age of the child witness did not significantly affect jurors' decision making. The results are discussed in relation to arguments regarding the abolition of the UK's TLD in favour of introducing a promise to tell the truth.
Iterative distributed fault detection and isolation for linear systems based on moving horizon estimation
Authors: Lauricella M. , Farina M. , Schneider R. , Scattolini R. 
Published: October 2019

SummaryIn modern engineering systems, reliability and safety can be conferred by efficient automatic monitoring and fault detection algorithms, allowing for the early identification and isolation of incipient faults. In case of large‐scale and complex systems, scalability issues and computational limitations make centralized monitoring and fault detection methods unapplicable. Research is therefore currently focusing on the development of distributed methods, where the computational complexity is divided among different units. In this paper, we propose a partition‐based model‐based fault detection and isolation scheme based on moving horizon estimation, able to estimate both the state variables and the possible faults, modeled as additive signals on the state and/or output equations. Its theoretical properties are analyzed, and numerical simulations are performed to witness its potentialities in a benchmark case study.
NIR/ROS‐Responsive Black Phosphorus QD Vesicles as Immunoadjuvant Carrier for Specific Cancer Photodynamic Immunotherapy
Authors: Li Zhi , Hu Yuehua , Fu Qinrui , Liu Yang , Wang Jie , Song Jibin , Yang Huanghao 
Published: October 2019

Abstract2D black phosphorus (BP) nanosheets and BP quantum dots (BPQD), as two main material styles of BP, are widely used in the biomedical filed. However, few stimuli‐responsive BP nanocarriers are reported to meet the need of nanomedicine. Herein, near‐infrared region/reactive oxygen species (NIR/ROS) sensitive BPQD vesicles (BPNVs) are prepared by self‐assembly of amphiphilic BPQDs grafted with polyethylene glycol and ROS sensitive poly(propylene sulfide) (PPS). BPNVs exhibit enhanced photo‐absorption in the NIR region, and have high loading efficiency of immunoadjuvant CpG oligodeoxynucleotides (CpG ODNs) in the cavity of the BPNVs. Upon NIR laser irradiation, high levels of ROS are generated from BPNVs to trigger the change of hydrophobic PPS to hydrophilic polymers, leading to disassembly of the vesicles to BPQDs. In this manner, the BPNVs show synergistic photodynamic therapy combined with immunotherapy, due to simultaneous release of small BPQDs with deep tumor penetration and CpG with enhanced immunotherapy. The BPNVs‐CpG achieves potent photodynamic immunotherapy in vivo, in addition to block distant tumor growth and metastasis.
Green Biocomposites for Thermoelectric Wearable Applications
Authors: Cataldi Pietro , Cassinelli Marco , Heredia‐Guerrero José A. , Guzman‐Puyol Susana , Naderizadeh Sara , Athanassiou Athanassia , Caironi Mario 
Published: October 2019

AbstractThe materials commonly used to fabricate thermoelectric devices are tellurium, lead, and germanium. These materials ensure the best thermoelectric performance, but exhibit drawbacks in terms of availability, sustainability, cost, and manufacturing complexity. Moreover, they do not guarantee a safe and cheap implementation in wearable thermoelectric applications. Here, p‐Type and n‐type flexible thermoelectric textiles are produced with sustainable and low‐cost materials through green and scalable processes. Cotton is functionalized with inks made with biopolyester and carbon nanomaterials. Depending on the nanofiller, i.e., graphene nanoplatelets, carbon nanotubes, or carbon nanofibers, positive or negative Seebeck coefficient values are obtained, resulting in a remarkable electrical conductivity value of 55 S cm−1 using carbon nanotubes. The best bending and washing stability are registered for the carbon nanofiber‐based biocomposites, which increase their electrical resistance by 5 times after repeated bending cycles and only by 30% after washing. Finally, in‐plane flexible thermoelectric generators coupling the best p‐ and n‐type materials are fabricated and analysed, resulting in an output voltage of ≈1.65 mV and a maximum output power of ≈1.0 nW by connecting only 2 p/n thermocouples at a temperature difference of 70 °C.
Quantum‐Dot Light‐Emitting Diodes for Outdoor Displays with High Stability at High Brightness
Authors: Li Xinyu , Lin Qingli , Song Jiaojiao , Shen Huaibin , Zhang Huimin , Li Lin Song , Li Xiaoguang , Du Zuliang 
Published: October 2019

AbstractQuantum dot light‐emitting diodes (QLEDs) are considered to be the candidate light sources with the most potential for applications in displays. Recent advances in luminance, external quantum efficiency (EQE), and even the operation lifetime of QLEDs have already satisfied the requirements for low‐light‐level displays. However, the short operation lifetime under high brightness limits the application of QLEDs for outdoor displays and lightings. Here, demonstrated are green QLEDs with a T95 operation lifetime reaching up to 2500 h at high brightness (1000 cd m−2) with a high peak EQE of 23.9%, current efficiency of 100.5 cd A−1, and low efficiency roll‐off at high current. Both the EQE and lifetime of the QLEDs are superior to those reported to date for all solution‐processed green QLEDs. These major advances are qualitatively attributed to the use of a shell‐tailoring strategy for producing compositional graded CdZnSe/ZnSe/ZnSeS/ZnS quantum dots with a high photoluminescence quantum yield, suppressed nonradiative Förster resonant energy transfer and Auger recombination, and favorable valence band alignment for enhanced hole injection. Collectively, this work represents a huge step forward in eventually realizing QLEDs for high‐brightness display and lighting applications.
Quantitatively Correlated Amplitude Holography Based on Photon Sieves
Authors: Xu Zhentao , Huang Lingling , Li Xiaowei , Tang Chengchun , Wei Qunshuo , Wang Yongtian 
Published: October 2019

AbstractAs an excellent holographic information carrier, metasurface holograms possess the advantages of subwavelength footprint, leading to large field of view and high resolution. Meanwhile, intelligent algorithms should be developed to fully exploit the flexible modulation properties provided by metasurfaces. Here, two amplitude holograms with quantitatively correlation are realized using the photon sieve as the amplitude modulation device. A new iterative algorithm is developed to obtain the amplitude profiles of the two holograms with correlation, which can make the two profiles mutually connect by simply adding/erasing dynamic pixels. Two photon sieves composed of nanoholes arrays are fabricated to demonstrate the feasibility of the scheme. This amplitude holography method can operate throughout the entire visible and near‐infrared wavelength regions with polarization independence, and it is expected to achieve switchable metasurface holography with the development of materials science. Such scheme promises to be applied in compact data storage, dual pattern recognition, optical encryption, and so on.
Transition‐Metal‐Free Three‐Component Synthesis of Tertiary Aryl Amines from Nitro Compounds, Boronic Acids, and Trialkyl Phosphites
Authors: Roscales Silvia , Csáky Aurelio G. 
Published: October 2019

AbstractThe synthesis of aromatic amines is of continuous interest in chemistry. An exceptionally versatile three‐component reaction that directly transforms inexpensive nitro compounds, boronic acids, and trialkyl phosphites into tertiary aromatic amines has been realized. The reaction tolerates alkyl and aryl substituents on the nitro and boronic acid moieties, as well as functionalized phosphites. No transition‐metal catalysis is required. The method is orthogonal to other classical metal‐catalyzed syntheses since it tolerates the presence of halogens, and also permits the synthesis of functionalized compounds such as α‐amino ester derivatives.magnified image
Maximizing Efficiency of Artificial Intelligence‐Driven Drug Combination Optimization through Minimal Resolution Experimental Design
Authors: Lim Jhin Jieh , Goh Jasmine , Rashid Masturah Bte Mohd Abdul , Chow Edward Kai‐Hua 
Published: October 2019

AbstractCombination therapy is critical to treating complex diseases, such as cancer. Optimizing drug combinations can be challenging when dealing with limited resources, such as patient tumor biopsies. This is due to the difficulty in screening large numbers of drug‐dose combinations as well as heterogenous patient responses. Developing a data‐driven approach that can efficiently and accurately determine the best drug combinations with the smallest number of experiments will have broad applications in both drug development as well as precision medicine. Quadratic Phenotypic Optimization Platform (QPOP) is an artificial intelligence (AI) approach that utilizes small experimental drug response datasets to accurately identify globally optimal drug combinations. QPOP exploits orthogonal array composite design (OACD), a combination of two‐level fractional factorial and three‐level orthogonal array components, to generate a minimal set of drug combinations sufficient for second‐order model fitting that is necessary to derive optimal drug combinations. In this study, a more efficient resolution IV OACD is able to derive optimal drug combinations and parabolic response surface maps, despite requiring fewer experimental runs than resolution V. As such, this study provides the framework for a more efficient OACD that can be applied toward AI‐driven drug combination design in patient‐based drug development and precision medicine.
Operando Observations of SEI Film Evolution by Mass‐Sensitive Scanning Transmission Electron Microscopy
Authors: Hou Chen , Han Jiuhui , Liu Pan , Yang Chuchu , Huang Gang , Fujita Takeshi , Hirata Akihiko , Chen Mingwei 
Published: October 2019

AbstractThe solid electrolyte interphase (SEI) spontaneously formed on anode surfaces as a passivation layer plays a critical role in the lithium dissolution and deposition upon discharge/charge in lithium ion batteries and lithium‐metal batteries. The formation kinetics and failure of the SEI films are the key factors determining the safety, power capability, and cycle life of lithium ion and lithium‐metal batteries. Since SEI films evolve with the volumetric and interfacial changes of anodes, it is technically challenging in experimental study of SEI kinetics. Here operando observations are reported of SEI formation, growth, and failure at a high current density by utilizing a mass‐sensitive Cs‐corrected scanning transmission electron microscopy. The sub‐nano‐scale observations reveal a bilayer hybrid structure of SEI films and demonstrate the radical assisted SEI growth after the SEI thickness beyond the electron tunneling regime. The failure of SEI films is associated with rapid dissolution of inorganic layers when they directly contact with the electrolyte in broken SEI films. The initiation of cracks in SEI films is caused by heterogeneous volume changes of the electrodes during delithiation. These microscopic insights have important implications in understanding SEI kinetics and in developing high‐performance anodes with the formation of robust SEI films.
A Comprehensive Analysis of the Interphasial and Structural Evolution over Long‐Term Cycling of Ultrahigh‐Nickel Cathodes in Lithium‐Ion Batteries
Authors: Li Jianyu , Manthiram Arumugam 
Published: October 2019

AbstractUltrahigh‐Ni layered oxides hold great promise as high‐energy‐density cathodes at an affordable cost for lithium‐ion batteries, yet their practical application is greatly hampered by the poor cyclability. Herein, by employing LiNi0.94Co0.06O2 as a model cathode in a full‐cell configuration, the interphasial and structural evolution processes of ultrahigh‐Ni layered oxides are systematically investigated over the course of their service life (1500 cycles). By applying advanced analytic techniques (e.g., Li‐isotope labeling, region‐of‐interest method), the dynamic chemical evolution on the cathode surface is revealed with spatial resolution, and the correlation between lattice distortion and cathode surface reactivity is established. Benefiting from in situ X‐ray diffraction (XRD) analysis, the ultrahigh‐Ni layered oxide is demonstrated to undergo dual‐phase reaction mechanisms with huge lattice variation, which leads to a decrease in crystallinity and secondary particle pulverization. Furthermore, the critical impact of cathode surface reaction on the graphite anode–electrolyte interphase (AEI) is revealed at nanometer scale, and a universal chemical/physical evolution process of the AEI is illustrated, for the first time. Finally, the practical viability of ultrahigh‐Ni layered oxides is demonstrated through Al‐doping strategy. This work presents a comprehensive understanding of the structural and interphasial degradation of ultrahigh‐Ni layered oxide cathodes for developing high‐energy‐density lithium‐ion batteries.
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies
Authors: Krohn Lynne , Öztürk Tuğba Nur , Vanderperre Benoît , Ouled Amar Bencheikh Bouchra , Ruskey Jennifer A. , Laurent Sandra B. , Spiegelman Dan , Postuma Ronald B. , Arnulf Isabelle , Hu Michele T. M. , Dauvilliers Yves , Högl Birgit , Stefani Ambra , Monaca Christelle Charley , Plazzi Giuseppe , Antelmi Elena , Ferini‐Strambi Luigi , Heidbreder Anna , Rudakou Uladzislau , Cochen De Cock Valérie , Young Peter , Wolf Pavlina , Oliva Petra , Zhang Xiaokui Kate , Greenbaum Lior , Liong Christopher , Gagnon Jean‐François , Desautels Alex , Hassin‐Baer Sharon , Montplaisir Jacques Y. , Dupré Nicolas , Rouleau Guy A. , Fon Edward A. , Trempe Jean‐François , Lamoureux Guillaume , Alcalay Roy N. , Gan‐Or Ziv 
Published: October 2019

ObjectiveThe TMEM175/GAK/DGKQ locus is the 3rd strongest risk locus in genome‐wide association studies of Parkinson disease (PD). We aimed to identify the specific disease‐associated variants in this locus, and their potential implications.MethodsFull sequencing of TMEM175/GAK/DGKQ followed by genotyping of specific associated variants was performed in PD (n = 1,575) and rapid eye movement sleep behavior disorder (RBD) patients (n = 533) and in controls (n = 1,583). Adjusted regression models and a meta‐analysis were performed. Association between variants and glucocerebrosidase (GCase) activity was analyzed in 715 individuals with available data. Homology modeling, molecular dynamics simulations, and lysosomal localization experiments were performed on TMEM175 variants to determine their potential effects on structure and function.ResultsTwo coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001). TMEM175 p.M393T was associated with reduced GCase activity. Homology modeling and normal mode analysis demonstrated that TMEM175 p.M393T creates a polar side‐chain in the hydrophobic core of the transmembrane, which could destabilize the domain and thus impair either its assembly, maturation, or trafficking. Molecular dynamics simulations demonstrated that the p.Q65P variant may increase stability and ion conductance of the transmembrane protein, and lysosomal localization was not affected by these variants.InterpretationCoding variants in TMEM175 are likely to be responsible for the association in the TMEM175/GAK/DGKQ locus, which could be mediated by affecting GCase activity. ANN NEUROL 2020;87:139–153
Distributions of Polycyclic Aromatic Hydrocarbons and Phthalic Acid Esters in Gums and Soapstocks Obtained from Soybean Oil Refinery
Authors: Chen Dongsheng , Shi Longkai , Song Gaoxiang 
Published: October 2019

AbstractSoybean oil gums and soapstocks are important by‐products that may potentially be contaminated by persistent organic pollutants (POP) such as polycyclic aromatic hydrocarbons (PAH) and phthalic acid esters (PAE), thus lowering the value when using them as starting materials to produce animal feed additives, food industry ingredients, and pharmaceutical products. In the present work, PAH and PAE distributions in these two types of by‐products were detected using solvent extraction–solid phase extraction purification coupled with gas chromatography–mass spectrometry. Total PAH and PAE amounts in the soapstocks were significantly higher than those in the gums, thus indicating that neutralization showed much higher removal efficiency than degumming in terms of PAH and PAE eliminations. Meanwhile, the results proved that the concentrations of these two kinds of contaminants in the soybean oil gums and soapstocks were much higher than those in the soybean oils, suggesting that further investigations were needed and that the contents of PAH and PAE in soybean oil refining by‐products should be carefully monitored and regulated.
Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome–Associated Arthritis
Authors: Foley C. , Floudas A. , Canavan M. , Biniecka M. , MacDermott E. J. , Veale D. J. , Mullan R. H. , Killeen O. G. , Fearon U. 
Published: October 2019

ObjectiveJuvenile idiopathic arthritis (JIA) is the most common inflammatory arthritis in children; however, an aggressive, erosive arthritis of little‐known immunologic mechanism occurs 20 times more frequently in children with Down syndrome. This study was undertaken to characterize T cell and B cell polyreactivity, follicular helper T (Tfh) cell, peripheral helper T (Tph) cell, and Treg cell responses, and synovial inflammation in Down syndrome–associated arthritis (DA).MethodsMultiparametric flow cytometric analysis and Simplified Presentation of Incredibly Complex Evaluations (SPICE) software were used to examine peripheral blood B cell populations and T cell cytokine responses in patients with DA, JIA, Down syndrome (trisomy 21 [T21]), and in healthy controls. Tfh and Tph cell frequency and origin, in addition to Treg cell frequency, were also evaluated. Synovial inflammation was assessed by immunohistology.ResultsExpansion of IgM‐only memory B cells was demonstrated in DA compared to JIA (mean ± SEM 22.48 ± 3.278 versus 9.011 ± 1.317; P = 0.005), paralleled by decreased frequency of transitional B cells. T cell responses in DA were characterized by marked functional plasticity, as was evident from the increased frequency of polyfunctional CD8+ Th cells (P < 0.05), CD161+ Th cells (P < 0.05), and CD8− Th cells (P < 0.001), and positivity for tumor necrosis factor, interferon‐γ, interleukin‐17A, or granulocyte–macrophage colony‐stimulating factor, compared to all other groups. Significant expansion of CXCR3+CCR6+ (Th1/Th17) Tfh cells (P = 0.003) and CXCR3+CCR6+ Tph cells (P = 0.01), paralleled by a decrease in CXCR3−CCR6− (Th2) Tfh cells was observed in DA compared to T21. Treg cells were significantly reduced in DA compared to T21 (mean ± SEM 7.111 ± 0.9518 versus 11.96 ± 1.055 versus; P = 0.0028), with a specific reduction in the naive:memory Treg cell ratio. Marked synovial tissue inflammation and increased T cell and B cell infiltrations were demonstrated in DA compared to JIA.ConclusionDA is more common and more aggressive than JIA. It is characterized by increased polyreactive Th, Tfh, and Tph cell responses, reduced Treg cell frequency, and evidence of increased synovial inflammation, all of which are potentially distinct from JIA and T21.
Simple Aggregation‐Induced Emission‐Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro
Authors: Lin Xueran , Zhao Junhao , Huang Wei , Liu Hongxing , Feng Pengju , Yang Fang , Chen Tianfeng 
Published: October 2019

AbstractMultifunctional nanoparticles were simply synthesized by mixing a TICT+AIE featured molecule (TPAPP‐CHO) with PBS solution. The fluorescent (FL) dots entered the cells via energy‐related endocytosis and were located in lysosome emitting green FL. This indicated that the nanoparticles were dissociated in the lysosome. Moreover, the synthesized nanoparticles (NPs) demonstrate potent cytotoxicity against human U87 glioblastoma cells by inducing cell apoptosis via triggering intracellular ROS overproduction.
Investigating the factor structure of the child behavior checklist dysregulation profile in children and adolescents with autism spectrum disorder
Authors: Keefer Amy , Singh Vini , Kalb Luther G. , Mazefsky Carla A. , Vasa Roma A. 
Published: October 2019

Dysregulation has been identified as an important risk factor for the development of psychiatric disorders in individuals with autism spectrum disorder (ASD). Therefore, it is necessary to empirically characterize dysregulation and identify psychometrically sound and readily available assessment methods in the ASD population. We sought to evaluate the factor structure of the Child Behavior Checklist‐Dysregulation Profile (CBCL‐DP), an established dysregulation measure in neurotypical children that is derived from the CBCL, in a large, clinically referred sample of children, ages 6–18 years, with ASD (n = 727). Confirmatory factor analysis was used to characterize dysregulation and assess the validity of the CBCL‐DP in children with ASD. Our findings support a bi‐factor model of dysregulation in which dysregulation is a broad and distinct syndrome that is associated with the three subdomains of the CBCL‐DP, anxiety/depression (AD), attention problems (AP), and aggressive behavior (AGG). Dysregulation was associated with most items in the AD and AGG domains and few items in the AP domain. This association with AD and AGG indicates that dysregulation in ASD may be conceptualized as the combined experience of internalized, negative mood states and externalized, reactive behaviors. These findings provide support as well as important caveats for the use of the CBCL‐DP as a measure of dysregulation in the ASD population. Autism Res 2020, 13: 436–443. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryDysregulation is a risk factor for psychiatric disorders in ASD. This study examined if the CBCL‐DP, an established measure of dysregulation in neurotypical children, can be used to assess dysregulation in children with ASD. Findings provide evidence that in ASD, dysregulation is a broad construct that exists alongside anxiety/depression, attention problems, and aggression. These findings indicate that the CBCL‐DP can be considered a valid measure of dysregulation in the ASD population and could be used in clinical settings.