bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain
Authors: Peyton Philip J. , Braat Sabine , De Silva Anurika , Story David , Evered Lisbeth , Myles Paul S. , Chan Matthew , Schug Stephan , Hogg Malcolm , Holmes Alex , Sidiropoulos Sofia , Leslie Kate 
Published: December 2024

Abstract
Background
Chronic post-surgical pain (CPSP) is recognised as one of the most common and debilitating complications of major surgery. Progression from acute to chronic pain after surgery involves sensitisation of central nervous system pathways with the N-methyl-D-aspartate (NMDA) receptor having a central role. Ketamine is a potent, non-selective NMDA antagonist commonly used for management of acute postoperative pain. Inconsistent but largely supportive evidence from small trials of a preventative effect of perioperative ketamine on CPSP risk suggests that a confirmative large trial is needed.

Methods
The ROCKet (Reduction Of Chronic Post-surgical Pain with Ketamine) Trial is a multicentre, double-blind, placebo-controlled, individually randomised superiority trial conducted in 36 hospitals across Australia, New Zealand, and Hong Kong. The trial aims to recruit 4884 patients undergoing abdominal, thoracic, or major orthopaedic surgery. Eligible participants are randomised equally to perioperative intravenous ketamine or placebo for up to 72 h. Incidence of pain in the area of the index surgery is measured by structured telephone interview at 3 months (primary trial endpoint) and 12 months. Pain severity, nature, and associated psychological and quality of life indices are measured using the modified Brief Pain Inventory short form, Neuropathic Pain Questionnaire, Kessler K-10 Psychological Distress Scale, Pain Catastrophising Scale, EQ-5D-3L, and measures of healthcare utilisation and costs. The trial is being conducted by the Department of Critical Care, University of Melbourne, and the Australian and New Zealand College of Anaesthetists Clinical Trials Network. The trial is funded by the Australian National Health and Medical Research Council.

Discussion
The ROCKet trial will clarify the effectiveness of ketamine in primary prevention of CPSP. In addition, it will provide high-quality, prospective data on the epidemiology of CPSP which will better inform further research into prevention and management of CPSP.

Trial registration
Australian New Zealand Clinical Trials Registry (ACTRN12617001619336) on the date of 12/11/2017.
Process-based therapy vs. routine-CBT for difficult-to-treat mood and anxiety disorders: study protocol for a randomized controlled trial
Authors: Stangier Ulrich , Kohl Viktoria , Görg Nora , Sendig Lucie , Hufschmidt Bettina , Bonarius Desiree , Nemani Arwin , Ebert Mareike , Hofmann Stefan G. 
Published: December 2024

Abstract
Background
Process-based therapy (PBT) is a new framework to intervention planning, based on the use of ecological momentary assessment (EMA) data and dynamic and idiographic network analyses. Support for its applicability has been reported from a single-case studies. Here, we examine the feasibility and effectiveness of PBT in a larger clinical sample. We have translated a training manual of PBT and modified for delivery of CBT in mental health service. The aim of this study is to test the relative efficacy of PBT compared to traditional CBT delivered in routine practice (r-CBT) for difficult-to-treat mood and anxiety disorders.

Methods
The study is a randomized controlled trial (RCT) of PBT vs r-CBT for difficult-to-treat unipolar depression and anxiety disorders. In total, 80 patients are recruited at an outpatient clinic and included in two intervention arms.
Primary outcome is emotional distress; secondary outcomes include psychological well-being and quality of life, adaptive behavior, psychological flexibility, and reflective functioning. Assessments of outcome variables are conducted before and after therapy and at 6 months follow-up. Weekly patient-rated outcomes are collected for every session to investigate process of change. Outcome assessors, blind to treatment allocation, will perform the observer-based symptom ratings, and adherence with manual will be monitored using self-report.

Discussion
The current study will be the first RCT of PBT in a health care setting. The planned moderator and mediator analyses will clarify the mechanisms of change in psychotherapy and the association between personalized assessment based on dynamic network analysis and treatment effect.

Trial registration
ClinicalTrials.gov NCT06517589. Registered 24 July 2024.
Cave-dwelling phlebotomine sand flies (Diptera: Psychodidae: Phlebotominae) in Thailand: population composition and pathogen detection of Bartonella and Trypanosoma
Authors: Sunantaraporn Sakone , Somwang Puckavadee , Khositharattanakool Pathamet , Unchanam Isaraporn , Saenchaiban Nattiya , Wongkhut Wilai , Sanum Pinpinat , Pataradool Thanapat , Boonserm Rungfar , Depaquit Jérôme , Siriyasatien Padet 
Published: December 2024

Abstract
Background
Leishmaniasis is an emerging vector-borne disease that occurs in Thailand. Although Leishmania (Mundinia) parasites, the causative agents of the disease have been identified, the vectors of the disease remain unidentified. In the present study, we collected sand flies from three caves located in endemic areas of leishmaniasis, including Lampang and Chiang Rai in northern Thailand, and Songkhla in southern Thailand.

Methods
Female sand flies were identified on the basis of morphological characteristics and confirmed by cytochrome c oxidase subunit I (COI) sequencing. Sand fly DNA samples were screened for Leishmania, Trypanosoma, and Bartonella DNA by polymerase chain reaction (PCR) on the basis of the ITS1 region of the ribosomal RNA (rRNA), SSU rRNA, and gltA genes, followed by phylogenetic relationships and haplotype diversity analysis.

Results
A total of 557 sand flies were identified, comprising four genera (Sergentomyia, Phlebotomus, Grassomyia, and Idiophlebotomus) and 11 species. Molecular detection of pathogens demonstrated that Leishmania DNA was not detected. However, Trypanosoma DNA was detected in 11 samples of Phlebotomus mascomai from Lampang (7 for T. noyesi), Se. anodontis from Chiang Rai (1 each for T. noyesi and Trypanosoma sp.), and Se. khawi from Songkhla (2 for Trypanosoma sp.). Bartonella DNA was detected in 16 samples of Se. anodontis and Se. barraudi s.l. from Chiang Rai, Se. anodontis from Lampang, and Se. khawi from Songkhla. The novel Bartonella sp. detected in Thai sand flies was phylogenetically related to Bartonella sp. from bats. Genetic diversity analysis showed high haplotype diversity in both Trypanosoma parasites and Bartonella bacteria.

Conclusions
The data from the present study indicate that phlebotomine sand flies could be potential vectors of zoonotic diseases caused by Trypanosoma sp. and Bartonella sp. To our knowledge, this is the first report of the natural infection of Bartonella associated with bats in Thailand, and the presence of T. noyesi and amphibian trypanosomes. However, further investigation is required to elucidate and enhance the understanding of potential vectors and transmission dynamics of pathogens in Thailand, particularly with regard to different seasonality, habitats, and host ranges.

Graphical abstract
The effects of message framing on US police chiefs’ support for interventions for opioid use disorder: a randomized survey experiment
Authors: del Pozo Brandon , Rouhani Saba , Bailey Amelia , Clark M. H. , Martins Kaitlin F. , Ahmed Fatema Z. , Atkins Danielle , Andraka-Christou Barbara 
Published: December 2024

Abstract
Background
US chiefs of police hold significant influence over the perceived acceptability and appropriateness of interventions for opioid use disorder (OUD) among the public, elected officials, and subordinate officers. This study assessed whether police chiefs’ support for such interventions was sensitive to framing an intervention’s benefits in terms that emphasize public health and harm reduction outcomes, versus terms typically indicative of public safety outcomes.

Methods
A two-armed survey utilizing a randomized, between-subjects design tested framing-based variance in support among US chiefs of police for overdose prevention centers, syringe service programs (SSPs), Good Samaritan laws, police naloxone distribution, trustworthiness of officers in recovery from OUD, and related propositions. Of 1,200 invitations, 276 chiefs participated (23%). The two experimental arms (n = 133, n = 143) were demographically balanced between both each other and non-respondents.

Results
Chiefs were more likely to agree that their mission was protecting public safety than protecting public health, even when both were defined using public health outcomes. Chiefs expressed significantly greater support for “overdose prevention sites” than “safe injection sites” (p = .018), low levels of support for SSPs regardless of framing (18% safety; 19% health), and comparably more support for Good Samaritan laws based on framing (62% safety vs. 54% health). Respondents voiced low levels of trust in officers recovering from OUD generally (31%), and significantly lower levels of trust when recovery involved the medication buprenorphine (10%; p < .001). Senior chiefs were significantly more likely to support SSPs (aOR 1.05; CI 1.01, 1.09) and overdose prevention sites (aOR 2.45; CI 1.13, 5.28) than less senior chiefs.

Conclusions
In this cross-sectional survey experiment, support for some interventions for OUD was greater among US chiefs of police when framed to emphasize positive public safety outcomes. Research is required to better understand low support for SSPs, mistrust of officers in recovery for OUD, and greater support for OUD interventions among senior chiefs.
Personality associations with online vs. offline social capital and life satisfaction
Authors: Chao Miao , Rozgonjuk Dmitri , Elhai Jon D. , Yang Haibo , Montag Christian 
Published: December 2024

Abstract
Social capital is an important construct in diverse scientific disciplines for understanding health promotion, entrepreneurship, and economic growth. In an increasingly digitalized world, social capital can be established and used in both online and offline contexts. Previous research suggests that personality might be relevant to an understanding of individual differences in social capital. For instance, the literature suggests that extraversion is associated with more social capital. Against this background, the present study aimed to revisit social capital research, but with a broader focus on studying all Big Five Personality traits (assessed with the BFI-45) and their association with bonding (similarity-based relationships), bridging (diversity-based relationships) social capital dimensions, and well-being. Insights in social capital variables in offline and online areas were obtained via the Internet Social Capital Scale and well-being was assessed with Diener’s Satisfaction with Life scale. In particular, the study aimed to understand if personality-well-being associations would emerge with online/offline social capital being a mediator. The questionnaires were filled in by n = 289 German speaking participants (73 males and 216 females). The results revealed that offline social capital in the form of bridging and bonding played a significant role in mediating the relationship between both agreeableness and extraversion with life satisfaction. Online social capital was not associated with life satisfaction and was only very weakly linked to some Big Five Personality traits. In conclusion, the present study demonstrates that offline social capital is very relevant for well-being, while online social capital shows no association with self-reported well-being levels and seems to be negligible for an understanding of well-being.
Harnessing large language models to develop research-based learning assistants for formative feedback
Authors: Steinert Steffen , Avila Karina E. , Ruzika Stefan , Kuhn Jochen , Küchemann Stefan 
Published: December 2024

AbstractEffectively supporting students in mastering all facets of self-regulated learning is a central aim of teachers and educational researchers. Prior research could demonstrate that formative feedback is an effective way to support students during self-regulated learning. In this light, we propose the application of Large Language Models (LLMs) to guide students towards problem-solving through formative feedback. We present LEAP, a novel platform that utilizes advanced LLMs, such as GPT-4o. LEAP empowers teachers with the ability to effectively pre-prompt and assign tasks to the LLM, resulting in formative feedback that stimulates students’ cognitive and metacognitive processes, thereby enhancing self-regulated learning. We demonstrate that a systematic prompt design can provide a wide range of types of scaffolds to students. These scaffolds, which are rooted in educational research, include sense-making, elaboration, self-explanation, partial task-solution scaffolds, as well as metacognitive and motivational scaffolds. Through this approach, we emphasize the critical importance of synchronizing educational technological advances with empirical research and theoretical frameworks. This alignment could potentially ensures the positive and effective application of LLMs in the educational landscape.
Optimized production of bacterioruberin from “Haloferax marinum” using one-factor-at-a-time and central composite design approaches
Authors: Cho Eui-Sang , Hwang Chi Young , Seo Myung-Ji 
Published: December 2024

AbstractHaloarchaea represents a unique group of microorganisms that have adapted to thrive in high-salt environments. These microbes produce distinctive biomolecules, some of which exhibit extraordinary properties. One such biomolecule is bacterioruberin, a prominent red-pigmented C50 carotenoid commonly found in halophilic archaea, renowned for its antioxidant properties and potential as a functional resource. This study aimed to enhance the culture conditions for optimal production of C50 carotenoids, primarily bacterioruberin, using “Haloferax marinum” MBLA0078. The optimization process involved a combination of one-factor-at-a-time (OFAT) and statistical methodology. Under OFAT-optimized conditions, fed-batch fermentation, and response surface methodology (RSM) optimization, carotenoid production reached 0.954 mg/L, 2.80 mg/L, and 2.16 mg/L, respectively, in a 7-L laboratory-scale fermenter. Notably, RSM-optimized conditions led to a 12-fold increase in productivity (0.72 mg/L/day) compared to the basal DBCM2 medium (0.06 mg/L/day). These findings suggest that strain MBLA0078 holds significant promise for commercial-scale production of bacterioruberin.
Graphical Abstract
Effect of the use of dapagliflozin in diuresis, natriuriesis, and in ultrafiltration and peritoneal elimination of sodium in patients with refractory heart failure: DAPA-DP study
Authors: Montomoli Marco , Solano Rivera Camila , Rico Miguel Gonzalez , De la Espriella Juan Rafael , Nuñez Marín Gonzalo , Puchades Montesa Maria Jesús , Gorriz Teruel Jose Luis 
Published: December 2024

Abstract
Background
Peritoneal dialysis (PD) has emerged as an effective technique for managing refractory heart failure (HF) in patients unresponsive to diuretics. Previous meta-analyses have demonstrated significant reductions in hospitalization days and improvements in cardiac function among patients with HF treated with PD compared with those receiving standard therapies. However, sodium retention remains a challenge in HF management, as patients often exhibit poor compliance with dietary sodium restrictions. In patients on PD, sodium retention exacerbates fluid overload and cardiovascular complications, highlighting the need for effective sodium elimination strategies.

Methods
This study will investigate the effects of PD on sodium excretion and its impact on mortality and heart failure exacerbations. We will enroll 31 patients with refractory HF in a continuous ambulatory peritoneal dialysis program. The study design includes randomization, a washout period, and an open-label approach to evaluate the impact of dapagliflozin, a sodium-glucose cotransporter-2(SGLT2) inhibitor, on sodium balance and clinical outcomes. Statistical analysis will be performed to assess changes in sodium excretion and the association between sodium removal levels and clinical outcomes.

Expected results
We hypothesize that dapagliflozin in patients undergoing PD will enhance net sodium loss by combining its known natriuretic efficacy with the hypothesis of increased sodium elimination in the peritoneal effluent. This effect is expected to be observed independently of the patients’ baseline renal function. Additionally, the study will investigate the safety profile of dapagliflozin in PD patients, monitoring for potential adverse effects and overall tolerability.

Conclusions
The study aims to provide valuable insights into optimizing HF management in PD patients through innovative therapeutic approaches. The anticipated findings could significantly impact clinical practice by improving sodium and fluid balance, potentially leading to reduced hospitalizations and better overall health outcomes for HF patients on PD.
Trial Registration: This study was approved and authorized by both the Spanish Agency of Drugs and Health Products (AEMPS) and the Hospital Clínico Universitario de Valencia Ethical Committee (CEIM). The investigated drug, dapagliflozin, has received approval from the European Medicines Agency (EMA) and has been authorized for commercialization in Spain (CEIM FILE: 148/23, CODE: DAPA-DP, EUDRACT no.: 2023-505571-78-00).
A systematic review of condition-specific preference-based measures used in young people and their valuation methods
Authors: King William , Hockley Lauren , Robinson Tomos , Bate Angela , Ternent Laura 
Published: December 2024

Abstract
Background
Condition-specific health-related quality-of-life (HRQoL) instruments can be more responsive and sensitive to specific conditions and diseases than generic HRQoL instruments. This systematic review aims to identify the condition-specific preference-based instruments that have been used with young people and identify how preference values have been obtained for these instruments. This review will inform future researchers about the methods used to elicit utilities for condition-specific HRQoL instruments.

Methods
A comprehensive search strategy was used to identify condition-specific HRQoL instruments used in young people and the methods used to value these instruments. Published medical and health economic databases were searched from January 1990–March 2022. Articles were deemed eligible for inclusion if a condition-specific preference-based instrument was used in young people (age < 18). Screening, data extraction and quality assessment were conducted independently by at least two reviewers.

Results
After deduplication, a total of 4273 articles were eligible for title and abstract screening. Of these, 98 articles were eligible for full-text screening. After full-text screening, 18 articles were included in the review. Valuation studies were the most prevalent study design in the review (44%), followed by mapping studies (38%) and then other designs (18%). Among the valuation studies, the choice of HRQoL instrument, preference elicitation method, anchoring method and perspective varied considerably.

Conclusion
To our knowledge, this review is the first to explore what condition-specific HRQoL instruments have been used in young people. Findings from this review could inform researchers in their choice of methods for measuring and valuing HRQoL. This review illustrates that to date there does not appear to be clear consensus of how to measure and value HRQoL in young people when using condition-specific instruments. The lack of consensus could be influenced by challenges identified in prior research such as limited guidance, ethical issues, and uncertain normative decisions regarding the choice of preference elicitation method. Ordinal methods such as discrete choice experiment and best-worst scaling appear to be preferable for use in this population.
Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia
Authors: Ranganathan Yeswanth , Nazar Saayaa , Krishnan Ravi Shankar , Dinakarkumar Yuvaraj , Varadarajan Vijayalakshmi , Sebastian Lenita , Rethinam Brindha 
Published: December 2024

Abstract

Background
Myocardial ischemia is a significant problem in cardiovascular health caused by the obstruction or constriction of coronary arteries, resulting in diminished blood supply to the heart muscle. Translational bioinformatics bridges the gap between biological discoveries and clinical applications, enabling early disease identification, therapy response confirmation, and prognosis prediction. It facilitates the integration and analysis of vast amounts of clinical data, hence advancing clinical research and enhancing therapeutic approaches.

Main body
This review explores the role of translational bioinformatics in understanding and treating cardiovascular disease, specifically Myocardial Ischemia. It covers the discovery of novel biomarkers (miRNA, lncRNA, and tsRNA), analysis of genes and proteins, and integrated bioinformatics to identify differentially expressed genes. The study highlights the impact of personalized medicine, drug discovery, and repurposing through bioinformatics. Additionally, it examines the application of systems biology and network analysis to understand biological networks, and the use of clinical decision support systems to enhance patient care. This integrative approach demonstrates the potential of bioinformatics to improve cardiovascular health outcomes.

Conclusions
Combining clinical and omics data using translational bioinformatics is critical for refining treatment regimens and speeding up medication repurposing. This comprehensive study emphasizes the necessity of combining interdisciplinary data to enhance patient outcomes in myocardial ischemia, minimize the global burden of cardiovascular-related deaths, and improve cardiovascular disease management.

Graphical abstract