bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arginine‐Loaded Nano‐Calcium‐Phosphate‐Stabilized Lipiodol Pickering Emulsions Potentiates Transarterial Embolization‐Immunotherapy
Authors: Wang Duo , Zhang Lei , Yang Wei‐Hao , Zhang Lin‐Zhu , Yu Chao , Qin Juan , Feng Liang‐Zhu , Liu Zhuang , Teng Gao‐Jun 
Published: December 2024

AbstractTransarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water‐in‐oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L‐arginine (L‐Arg), which is known for its ability to modulate T‐cell metabolism. The obtained L‐Arg‐loaded CaP‐stabilized lipiodol Pickering emulsion (L‐Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also enable the release of L‐Arg, thereby synergistically promoting the reinvigoration of exhausted CD8+ T cells and effectively reversing tumor immunosuppression. As a result, TACE therapy with L‐Arg@CaPL shows greatly improved therapeutic responses as demonstrated in an orthotopic liver tumor model in rats. This study highlights an effective yet simple nanoparticle‐stabilized Pickering emulsion strategy to promote TACE therapy via modulation of the immunosuppressive TME, presenting great potential for clinical translation.
Constructing Quasi‐Localized High‐Concentration Solvation Structures to Stabilize Battery Interfaces in Nonflammable Phosphate‐Based Electrolyte
Authors: Shi Chenyang , Wang Mengran , Tehrani Zari , Hong Bo , Wang Mengnan , Tan Rui , Margadonna Serena , Lai Yanqing , Titirici Maria Magdalena 
Published: December 2024

AbstractFlame‐retardant phosphate‐based electrolytes effectively enhance lithium‐ion battery safety but suffer from poor compatibility with graphite anodes and high‐voltage cathodes, hindering scalability. Fluorinated phosphates, though widely used, increase interfacial resistance at the anode, degrading performance. In this work, carbonate solvents with strong polarity are introduced to prevent tris(2,2,2‐trifluoroethyl) phosphate (TFEP) from participating in the solvation structure of lithium ions. This strategy forms a quasi‐localized high‐concentration solvation structure, thereby restricting the reduction of TFEP and its impact on the graphite anode. The LiNi0.8Mn0.1Co0.1O2 (NCM811) | Graphite (Gr) pouch cell with optimized electrolyte exhibits a capacity retention rate of 80.1% after 370 cycles at 0.5C, which is much more stable than the electrolyte with TFEP‐involved solvation structure (capacity retention rate: 47.1% after 300 cycles). The corresponding pouch cell with cut‐off voltage to 4.5 V exhibits a capacity retention rate of 82.8% after 125 cycles, significantly outperforming cells employing commercial carbonate electrolytes (capacity retention rate: 56.9% after 125 cycles). Thus, the developed quasi‐localized high‐concentration solvation structure can effectively stabilize the electrode interface, greatly enhancing the cycling performance of phosphate‐based flame‐retardant electrolytes.
Hypoxia Microenvironment Preconditioning Attenuated Myocardial Ischemia‐Reperfusion Injury via Stc1‐Mediating Cardiomyocyte Self‐Protection and Neutrophil Polarization
Authors: Huang Haoxiang , Ruan Yifei , Li Chuling , Zheng Hao , Tang Yating , Chen Yijin , He Fengling , Liu Yu , Wu Guangkai , Li Zhenhua , Wang Yuegang , Liao Yulin , Bin Jianping , Chen Yanmei 
Published: December 2024

AbstractIschemic preconditioning (IPC) therapy application to attenuate myocardial ischemia‐reperfusion (MI/R) injury in clinical practice remains challenging. The secretome, derived from hypoxia‐preconditioned cardiomyocytes (SHPC), potentially mimics the IPC microenvironment and facilitates IPC clinical translation. This study aims to determine whether SHPC can be a feasible alternative to IPC for attenuating MI/R injury, and to identify the functional factor of SHPC. The ultrafiltration technique is applied to generate an SHPC formulation that is intramyocardially injected before reperfusion in a murine MI/R model. The effects of SHPC on cardiomyocyte apoptosis, pyroptosis, and neutrophil polarization are evaluated. Secretomics, neutralizing antibodies, and recombinant proteins are employed to identify the functional factor in SHPC. Co‐immunoprecipitation assays, RNA sequencing, and site‐directed mutagenesis are conducted to investigate the underlying mechanism. Additionally, a recombinant functional factor‐encapsulated hydrogel is developed for intrapericardial injections (iPC). An intramyocardial SHPC injection in MI/R‐injured mice strikingly reduces infarct size and the expression of cardiac injury biomarker while improving cardiac function. SHPC eliminated mitochondrial reactive oxygen species and triggered neutrophil polarization to reduce cardiomyocyte apoptosis/pyroptosis upon hypoxia/reoxygenation injury. Stanniocalcin 1 (Stc1) is identified as the functional factor in SHPC, mediating hypoxic microenvironment. Mechanistically, hypoxia‐preconditioned cardiomyocytes secrete Stc1 into the microenvironment and activate calcium‐sensing receptor (CaSR) that increases Stat3 phosphorylation at Ser727 via nitric oxide synthase 2 (NOS2)‐mediated S‐nitrosylation, thereby decreasing cardiomyocyte apoptosis/pyroptosis in an autocrine mechanism. Simultaneously, Stc1 facilitates cardiomyocyte‐neutrophil crosstalk, thereby triggering neutrophil polarization to reduce inflammatory damage via the CaSR/NOS2/Stat3 axis in a paracrine mechanism. Pericardial delivery of a recombinant rStc1‐encapsulated hydrogel has extended the therapeutic time window of rStc1, improving long‐term cardiac function. The hypoxia microenvironment preconditioning, which mimicked by SHPC, attenuated MI/R injury via Stc1‐mediated cardiomyocyte self‐protection and neutrophil polarization. This study suggests that SHPC, with hypoxia preconditioning factor Stc1, represents a clinically feasible alternative to IPC for attenuating MI/R injury.
Diverse N‐Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual‐Functional Small Molecule
Authors: Chen Jie , Yao Fuquan , Jiang Yiping , Qin Xiangquan , Xian Mo , Feng Yingang , Cong Zhiqi 
Published: December 2024

AbstractAmine oxidation is an important organic reaction for the production of high‐value N‐containing compounds. However, it is still challenging to control the reactivity of active N‐centered radicals to selectively access N‐oxidation products. Herein, this study reports the engineering of cytochrome P450BM3 into multifunctional N‐oxidizing enzymes with the assistance of dual‐functional small molecules (DFSM) to selectively produce N‐oxygenation (i.e., p‐nitrosobenzene, p‐nitrobenzene, and azoxybenzene) and one‐electron oxidation products (i.e., oligomeric quinones and azobenzene) from aromatic amines. The best mutant, F87A/T268V/V78T/A82T, exclusively gives p‐nitrosobenzene (up to 98% selectivity), whereas the selectivity for p‐nitrobenzene is >99% using the mutant F87A/T268V/A82T/I263L. Crystal structure analysis reveals that key mutations and DFSM exert synergistic effects on catalytic promiscuity by controlling the substrate orientation in active center. This study highlights the potential of DFSM‐facilitated P450 peroxygenase and peroxidase for the synthesis of N‐containing compounds via the controllable oxidation of aromatic amines, substantially expanding the chemical space of P450 enzymes.
SREBP1c‐Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells
Authors: Xin Wang , Zhou Jie , Peng Yuzhu , Gong Shuiqin , Liao Wenhao , Wang Yaqin , Huang Xixin , Mao Yang , Yao Mengying , Qin Shaozong , Xiong Jiachuan , Li Yan , Lan Qigang , Huang Yinghui , Zhao Jinghong 
Published: December 2024

AbstractAcute kidney injury (AKI) is a prevalent clinical syndrome with high morbidity and mortality. Accumulating studies suggest mitochondrial dysfunction as the typical characteristics and key process of AKI, but the underlying mechanism remains elusive. The YME1‐like 1 (YME1L1) ATPase, an inner mitochondrial membrane protein, is screened and identified to be downregulated in renal tubular epithelial cells of various mouse models and patients of AKI. Dramatically, restoration of YME1L1 expression significantly alleviates cisplatin‐induced AKI and subsequent chronic kidney disease (CKD) through attenuating mitochondrial dysfunction via maintaining optic atrophy 1 (OPA1)‐mediated mitochondrial energy metabolism homeostasis. Mechanistically, the upregulated expression of sterol regulatory element binding transcription factor 1c (SREBP1c) is demonstrated to be responsible for cisplatin‐mediated transcriptional inhibition of YME1L1 via directly binding to its promoter region. Moreover, cisplatin‐induced methyltransferase‐like 3 (METTL3)‐mediated m6A modification enhances SREBP1c mRNA stability, thereby upregulating its expression. Notably, both depletion of SREBP1c and renal tubule‐specific overexpression of YME1L1 markedly ameliorate cisplatin‐induced AKI and its transition to CKD. Taken together, these findings suggest that METTL3‐mediated SREBP1c upregulation contributes to AKI and its progression to CKD through disrupting mitochondrial energy metabolism via transcriptionally suppressing YME1L1. Targeting the SREBP1c/YME1L1 signaling may serve as a novel therapeutic strategy against AKI.
Engineered Sodium Metal Anodes: Tackling Sulfur‐Derivative Challenges for Advanced Sodium–Sulfur Batteries
Authors: Zhao Qing , Mei Tiehan , Li Yi , Lin Xitao , Niu Yubin , Jiang Jian , Xu Maowen , Qi Yuruo 
Published: December 2024

AbstractThe development of room temperature sodium–sulfur (RT Na─S) batteries has been significantly constrained by the dissolution/shuttle of sulfur‐derivatives and the instability of sodium anode. This study presents an engineered sodium metal anode (NBS), featuring sodium bromide (NaBr) along with sodiophilic components like tin metal (Sn) and sodium‐tin (Na─Sn) alloy. This configuration exhibits high plating/stripping reversibility with minimal nucleation/growth barriers in an ester‐based electrolyte, allowing stable cycling of symmetric cells at 2 mA cm⁻2/2 mA h cm⁻2 for over 2000 h at a low overpotential of 30 mV. Importantly, the weak adsorption and reduced electron transfer towards sulfur‐derivatives, along with the facile dissociation of Na2S2/Na2S, effectively minimize the accumulation of sulfur‐derivatives, thereby improving the interfacial stability of the NBS electrode in sulfur‐derivatives‐involved conditions. As a result, the NBS anode endows the Na─S full cells paired with either a Co‐NMCN@S or SPAN cathode superior electrochemical performance, with the SPAN//NBS system delivering an outstanding reversible capacity of 1639.5 mA h g⁻¹ and a low degradation rate of 0.06% per cycle at 0.5C. This study elucidates the complex deposition/dissolution kinetics and interface chemistry associated with sulfur species, providing valuable insights for enhancing sodium anodes in practical RT Na─S systems.
Fluctuation of tissue eosinophils in chronic rhinosinusitis with nasal polyp
Authors: Sombutpiboonphon Kunjira , Snidvongs Kornkiat , Lawpoolsri Saranath , Chotikawichean Nutpacha , Kowatanamongkon Patlada , Mongkolkul Kittichai , Chitsuthipakorn Wirach 
Published: December 2024

AbstractIntroductionTissue eosinophil count (TEC) is recommended for defining Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). TEC is usually assessed by a one‐time polyp biopsy. Because TEC may change over time, its reliability for diagnosing type 2 CRSwNP has not been previously assessed. This study aims to explore whether TEC fluctuates across different time points.MethodsAdult patients with CRSwNP were prospectively recruited at Rajavithi Hospital, Thailand. Participants who had used any form of steroids within 4 weeks were excluded. Polyps were taken for TEC evaluation upon recruitment and repeated at 3 and 6 months. Participants were assessed using the 22‐items Sinonasal Outcome Test (SNOT‐22), Lund–Kennedy endoscopic score (LKES), blood eosinophil count, and its percentage at each time point.ResultsThirty‐seven participants were enrolled. The medians (Quartiles 1–3) of TEC were 17 (4–53.5), 19 (5–47.5), and 21 (4.5–51) cells/high‐powered field at 0, 3, and 6 months, respectively. Friedman's two‐way analysis of variance showed no statistical differences across the three time points for TEC (p = 0.53), blood eosinophil counts (p = 0.61), blood eosinophil percentages (p = 0.23), SNOT‐22 (p = 0.21), or LKES (p = 0.23). TEC significantly correlated with blood eosinophil counts at 0 and 3 months and with blood eosinophil percentages at 0, 3, and 6 months (all p < 0.05).ConclusionThe study showed that TEC did not significantly fluctuate over time, aligning with blood eosinophil levels, SNOT‐22, and LKES. This stability within the 6‐month period supports the reliability of TEC from a single biopsy for clinical use in managing CRSwNP.
Novel Mononuclear Cu(II), Ni(II), and Co(II) Complexes of Coumarinyl‐Pyrazolyl‐Thiazole Thiosemicarbazone: Synthesis, Characterization, and Biological Evaluation
Authors: Shebl Magdy , Ali Tarik E. , Assiri Mohammed A. 
Published: December 2024

ABSTRACTCu(II), Ni(II), and Co(II) acetates reacted with a thiosemicarbazone ligand (CPPTSC; HL) to produce novel solid complexes with the general formula [M(L)(H2O)m]·nH2O, m = 2 or nil, n = 1 or nil, M = Cu(II), Ni(II), and Co(II). Several analytical and spectroscopic techniques have been efficiently used to characterize the synthesized chelates. The investigated CPPTSC ligand functions as a monoanionic tridentate in all chelates. Measurements of molar conductivity showed that all chelates behaved in a non‐electrolytic manner. In contrast to nickel‐CPPTSC and cobalt‐CPPTSC complexes, which showed tetrahedral geometries, the copper‐CPPTSC complex showed a distorted octahedral geometry. The thermal decomposition behaviors of CPPTSC complexes were examined using TG. To assess the molecular structural characteristics of CPPTSC and its complexes, density functional theory (DFT) was applied at the B3LYP/6‐311G(d,p) and LanL2dz levels. The antiproliferative properties of CPPTSC and its chelates against two human cancer cell lines, HepG‐2 (hepatic) and MCF‐7 (breast), were evaluated. The Cu‐CPPTSC and Ni‐CPPTSC complexes displayed the superior IC50 values compared with doxorubicin, suggesting a potentially improved therapeutic index. The bioactive Cu‐CPPTSC and Ni‐CPPTSC complexes markedly increased the late apoptosis of all studied tumor cells. The Cu‐CPPTSC and Ni‐CPPTSC complexes showed great cell cycle arrest in the G2 phase and moderate cell cycle arrest in the S phase. The discovered Cu‐CPPTSC and Ni‐CPPTSC complexes were then subjected to a molecular docking experiment and displayed good interactions with CDK‐2 receptor.
Frontal Polymerization of Phytic Acid Containing Hexaacrylate, Triacrylate, and Fillers
Authors: Martinez Maria , Bansal Karan , Pojman John A. , Quadir Mohiuddin 
Published: December 2024

ABSTRACTFrontal polymerization (FP) has been used in the application of coatings, adhesive, and composites. In this work, a new bio‐based phytic acid monomer, known as phyto‐urethane acrylate (PUA) with demonstrated flame retardant abilities, has been incorporated and frontally polymerized into a base formulation composed of trimethylolpropane triacrylate (TMPTA), a peroxide thermal radical initiator and fumed silica. This is the first report of a hexaacrylate monomer cured via FP. Four different fillers (magnesium hydroxide, nano zinc oxide, milled carbon fiber, and melamine), known for their flame‐retardant properties were also incorporated into the base formulation along with PUA resin. The front velocity, front temperature and viscosity were studied for all formulations in detail. Thermal analysis of the composites showed that composites prepared in this research have high glass transition temperature above 200°C and degradation temperature above 300°C. Surface properties before and after burning events were captured via SEM, and it was found that formulation containing PUA resin showed bubble morphology, which indicates char formation. Microcomputed tomography (μ‐CT) showed that quantity and morphology of the pores in the composites can be altered with the incorporation of PUA resin and fillers.
Preparation of Highly Aminated Polystyrene Resin Beads for CO2 Adsorption
Authors: Meng Qi , Niu Hao , Liu Penghao , Cao Yiwen , Wang Meiling , Jia Ninghong , Teng Qiaoqiao , Chen Shengbin 
Published: December 2024

ABSTRACTA methodology of using chloroacetylated polystyrene resin (PS‐COCH2‐Cl) to initiate the ring‐opening polymerization of oxazolines was established to prepare highly amininated polystyrene (PS) resin beads for CO2 adsorption. The structure of the resulting material was fully characterized by FTIR, BET, TGA, and XPS, and the results suggested that the chloroacetyl group was more reactive in initiating the ring‐opening polymerization of oxazolines than the known chloromethyl groups, which eliminated the use of iodide salts that are costly. The resulting material could adsorb CO2 at an equilibrium adsorption capacity of 3.15 mmol/g at 25°C and 1 atm, and the adsorption isotherms conformed to the Freundlich isothermal model, indicating a multi‐layer adsorption type. Kinetic study suggested that the adsorption was predominantly governed by chemical interactions with physical adsorption playing a supportive role. For a simulated flue gas of 15% CO2/N2, 50°C, relative humidity of 80%, SO2 concentration of 50 ppm, the adsorption performance of PS‐COCH2‐LPEI was even improved and the capacity can be well retained for at least 20 adsorption–desorption cycles, demonstrating a promising application prospect of this solid polyamine material in removing CO2 from flue gas.
Evolution of the “long‐tail” concept for scientific data
Authors: Stahlman Gretchen R. , Kouper Inna 
Published: December 2024

AbstractThis review paper explores the evolution of discussions about “long‐tail” scientific data in the scholarly literature. The “long‐tail” concept, originally used to explain trends in digital consumer goods, was first applied to scientific data in 2007 to refer to a vast array of smaller, heterogeneous data collections that cumulatively represent a substantial portion of scientific knowledge. However, these datasets, often referred to as “long‐tail data,” are frequently mismanaged or overlooked due to inadequate data management practices and institutional support. This paper examines the changing landscape of discussions about long‐tail data over time, situated within broader ecosystems of research data management and the natural interplay between “big” and “small” data. The review also bridges discussions on data curation in Library & Information Science (LIS) and domain‐specific contexts, contributing to a more comprehensive understanding of the long‐tail concept's utility for effective data management outcomes. The review aims to provide a more comprehensive understanding of this concept, its terminological diversity in the literature, and its utility for guiding data management, overall informing current and future information science research and practice.
Principle Design of C−C Coupling Pathway Towards Highly Selective C2 Products Using Photocatalytic CO2 Reduction:A Review
Authors: Liu Qian , Yang Guang , Li Ruru , Yang Xiaowen , Duan Yingnan , Chen Fangyuan , Shen Zhurui 
Published: December 2024

AbstractPhotocatalytic conversion of environmental CO2 into valuable fuels is expected to alleviate fossil fuel and pollution problems. However, intricate product‐reaction pathways complicate the regulation of product selectivity. Most studies in this field have focused on increasing productivity rather than on controlling product formation. To date, the major products of photocatalytic CO2 reduction reactions (CO2RRs) are C1 compounds, as opposed to the higher‐value C2 compounds, because of the low C2 selectivity of this process. The design of C−C coupled pathways is paramount to facilitate selective access to C2 products in the photocatalytic CO2RR. In this review, we discuss the mechanisms and pathways of CO2RR product generation based on recent research results and summarise the work on CO2RR to C2 products. This review aims to modulate the product‐generation pathway to improve the yield and selectivity of C2 products by facilitating C−C coupling reactions. Finally, some of the current challenges in the field of the CO2RR to C2 are outlined, including possible mechanistic interpretations, cost of catalyst use, reactor design, and potential solutions.
LOIN für Elemente des geologisch‐geotechnischen Baugrundmodells
Authors: Massimo‐Kaiser Ines M. , Fröch Georg , Salzgeber Hannah , Flora Matthias 
Published: December 2024

AbstractDie ÖNORM EN 17412‐1 definiert die Informationsbedarfstiefe bzw. den Level of Information Need (LOIN) durch klare Vorgaben zu Anforderungen und Verantwortlichkeiten, die Einbindung von geometrischen und alphanumerischen Informationen sowie Dokumentationsvorgaben. Für geologisch‐geotechnische Baugrundmodelle wurde der LOIN mit dem Ziel einer Definition für Baugrundelemente noch nicht näher beschrieben. Bisherige Arbeiten fokussierten sich auf die geometrische Umsetzung von Baugrundmodellen, hier erfolgt nun die erweiterte Beschreibung des LOIN um alphanumerische Informationen. Es wird erläutert, wie geologische Informationen der vier Planungsphasen Grundlagenerhebung, Erkundungsplanung, Erkundung und Interpretation strukturiert und vollständig in digitale Modelle zu implementieren sind, um eine verlustfreie Übergabe an die geotechnische Planung zu gewährleisten. Eine projektbezogene Definition des LOIN für spezifische Baugrundelemente, sowie beispielhaft für das Element Bohrung, ermöglicht eine präzise und strukturierte Bereitstellung von Daten, vermeidet Informationsüberschuss und unterstützt fundierte Entscheidungen sowie eine effiziente Planung über den gesamten Lebenszyklus eines Bauwerks. Betont werden die Notwendigkeit eines klar definierten LOIN sowie die frühzeitige Einbindung und Abstimmung mit den Projektbeteiligten für eine effektive geotechnische Planung und die fortlaufende Modellierung geologischer Daten.
Wiederverwendung im Tragwerk
Authors: Nowak Jana , Kummert Clea , Oppe Matthias 
Published: December 2024

AbstractWiederverwendung (engl. Re‐Use) von Bauprodukten ist eine der wichtigsten Strategien, um eine klimagerechte und regenerative Bauwirtschaft zu etablieren. Dennoch stehen v. a. dem Bauen mit gebrauchten tragenden Bauteilen bislang sowohl regulatorische Hürden als auch der übliche lineare Planungsprozess im Weg. Die Wiederverwendung gebrauchter Stahlträger aus dem Treppenturm eines Parkhauses in Stuttgart zeigt als Pilotprojekt das große Potenzial von Re‐Use tragender Bauteile auf. Die damit einhergehende Emissionseinsparung konnte mithilfe der Ökobilanzierung quantifiziert werden. Eine Betrachtung der zukünftigen Kreislauffähigkeit zeigt die Grenzen dieser Methode für eine umfassende Betrachtung der ökologischen Mehrwerte auf. Um diese einheitlich messbar zu machen und damit die Umsetzung einer Kreislaufwirtschaft im Bauwesen zu begünstigen, muss die Methode der Ökobilanzierung um eine Zirkularitätsbewertung ergänzt werden.