bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analysis of domestic homicide review recommendations for adult safeguarding in England
Authors: Chantler Khatidja , Baker Victoria , Gunby Clare , Heyes Kim 
Published: December 2024

Purpose
The purpose of this paper is to analyse recommendations made in domestic homicide reviews (DHRs) in England relating to adult safeguarding – largely focussing on those aged 66+ − to identify key areas for learning and how equality, diversity and inclusion issues (EDI) are considered in DHRs.

Design/methodology/approach
A mixed methods approach was used to analyse 24 DHRs spanning 2015–2018. A qualitative template was created to extract information, followed by a critical thematic analysis. A quantitative matrix was then developed, enabling a descriptive quantitative analysis, identifying the most prevalent types of recommendations. An additional descriptive quantitative analysis of the 24 DHRs was undertaken for context.

Findings
Intimate partner homicide comprised half the homicides (12); adult family homicide comprised 11; and one homicide was an amicicide. DHRs recommended improvements in: information management/multi-agency working (83%); targeted domestic abuse training (67%); developing/abiding by policies (67%); enhancing professional practice (54%); improved domestic abuse risk and carers assessments (50%). EDI was seldom considered.

Originality/value
New analysis is provided on the different types and contexts of domestic homicides involving older adults, the need for strengthened guidance regarding DA and adult safeguarding, tailored DA training and challenging “blind spots” relating to ageist assumptions, the invisibility of familial abuse, a lack of service oversight where care is self-funded and limited consideration of EDI.
What factors mediate the relationship between principal leadership and teacher professional learning? Evidence from meta-analytic structural equation modelling (MASEM)
Authors: Karakose Turgut , Tulubaş Tijen , Kanadli Sedat , Gurr David 
Published: December 2024

PurposeThis study was conducted to investigate the effect of principal leadership (PL) on teacher professional learning (TPL) with the possible mediation of teacher trust (TT) and teacher agency (TA) using a broader set of data collected from published research.Design/methodology/approachThe study uses meta-analytic structural equation modelling to compare weighted effect sizes between variables produced by research across different periods and contexts. The bilateral relations of PL with study variables were first examined, and then the model-data fit was tested for both the proposed and the two alternative models.FindingsThe results showed that PL had a significant and “very large” effect on TPL, TT and agency; PL affected TPL mostly indirectly over TT and agency. TT and agency collectively predicted nearly half of the variance in TPL.Originality/valueThe study uses a novel and advanced methodology to investigate the relationships among the study variables using data from 59 studies with a sample size of 67,035 participants from around the world. The results contribute to the literature, offering a more global understanding of the interaction of PL, TPL, trust and agency.
Design simulation and process realization of a flexible MEMS vector hydrophone
Authors: Wu Jiaxing , Renxin Wang , Zhang Xiangkai , Li Haoxuan , Liu Guochang , Dong Xuejing , Zhang Wendong , Zhang Guojun 
Published: December 2024

Purpose
This study aims to design a small-size conformable flexible micro-electro-mechanical system (MEMS) vector hydrophone to meet the miniaturization requirements of unmanned underwater vehicle.

Design/methodology/approach
The cilia receive the acoustic signal to oscillate to cause changes in the stress on the beam, which in turn causes changes in the piezoresistive resistance on the beam, and changes in the resistance cause changes in the output voltage.

Findings
The results show that the flexible hydrophone in the paper has a sensitivity of −182 dB@1 kHz (re 1V/µPa) at 1 Pa sound pressure, can detect low-frequency hydroacoustic signals from 20 to 550 Hz and has good spatial directivity, and the flexible substrate permits the hydrophone to realize bending deformation, which can be well attached to the surface of the object.

Originality/value
In this study, a finite element simulation model of the hydrophone microstructure is constructed and its performance is verified by simulation. The success rate of the proposed MEMS transfer process is as high as 94%, and the prepared piezoresistors exhibit excellent resistance characteristics and high consistency. These results provide innovative ideas to enhance the performance and stability and achieve miniaturization of hydrophones.
Moderated-mediation of competitive aggressiveness and green supply chain learning in the relationship between green entrepreneurial orientation and cleaner production practices
Authors: Farooq Muhammad Shoaib , Salam Maimoona 
Published: December 2024

Purpose
The relationship between corporate-level green entrepreneurial orientation (GEO) and the implementation of cleaner production practices (CPPs) is to a great extent unexplored in previous literature. This study aims to connect them with the corporate-level green supply chain learning and organizational competitive aggressiveness, presenting a novel interpretation of social ethics and morality in CPPs.

Design/methodology/approach
To thoroughly explore this novel relationship, this study has used PLS-SEM for examining the moderated-mediation of competitive aggressiveness and green supply chain learning.

Findings
Findings based on the data collected from 176 German firms have largely confirmed our propositions. Suggesting that there is a strong positive relationship between corporate level GEO and CPPs. Furthermore, our findings have confirmed that green supply chain learning mediates the macro-level relationship between GEO and CPPs. Moreover, it is also confirmed that the mediation of green supply chain learning in the macro-level relationship between GEO and CPPs is negatively moderated by competitive aggressiveness.

Originality/value
This study offers a first-hand view of negatively moderated-mediation of competitive aggressiveness. Therefore, its findings are extremely relevant for policymakers in the domain of morality, social ethics, corporate-level GEO, sustainability, corporate-level green supply chain learning and CPPs.
Large‐scale forest disturbance and associated management shape bird communities in Central European spruce forests
Authors: Graser Anne , Georg Malte , Kallmayer Josef , Marten Andreas , Pertl Caren , Rumpf Hendrik , Senf Cornelius , Kamp Johannes 
Published: December 2024

Abstract

In Central Europe, natural forest disturbance is increasing due to climate change and the legacies of past forest management. The resulting early successional forest stages shape habitat conditions and availability for forest‐dwelling species. How disturbance, pre‐disturbance forest management such as beech underplanting in conifer stands and post‐disturbance management, such as salvage logging, shape biodiversity is poorly understood.

In a large field study, we quantified how the large‐scale loss of mature spruce plantations after natural disturbance affects bird diversity and abundance in Central Europe and how this is moderated by pre‐ and post‐ disturbance management. In a Bayesian community distance sampling approach, we conducted field surveys on 182 plots in a stratified design, comparing bark beetle and windthrow disturbances as well as two management treatments, (i) underplanting with beech before the disturbance occurred versus no underplanting and (ii) salvage logging versus no post‐disturbance logging. We used undisturbed mature spruce plantations as a control.

Bird diversity was higher in disturbed forests than in undisturbed spruce plantations and was affected little by management. Bayesian community distance sampling models revealed that responses were highly species‐specific: shrub‐associated birds profited from disturbance in general and reached highest densities where beech had been planted under the spruce canopy before the disturbance occurred, whereas open‐habitat and farmland birds reached higher densities on salvage‐logged sites. Only few typical species of coniferous forests persisted at disturbed sites.

Synthesis and applications. With increasing forest disturbance, pre‐ and post‐disturbance management can promote target bird species. Shrub‐associated species can be promoted by underplanting, open habitat‐adapted species by salvage logging and species depending on vertical structures by no intervention. For maximising biodiversity benefits at a landscape scale, underrepresented management practices (no intervention) should be promoted to ensure a balanced forest management and to maintain diverse post‐disturbance bird communities.
Technological innovations in margarine production: Current trends and future perspectives on trans‐fat removal and saturated fat replacement
Authors: Bihola Ankit , Chaudhary M. B. , Bumbadiya M. R. , Suvera Priyanka , Adil Shaikh 
Published: December 2024

AbstractThe margarine market is growing globally due to its lower cost, ease of availability, large‐scale commercialization, and expanding market in the bakery and confectionary industries. Butter contains greater amounts of saturated fat and has been associated with cardiovascular diseases. The trans fats generated through the hydrogenation process have several adverse impacts on human health, such as the risk of atherosclerosis, coronary heart disease, postmenopausal breast cancer, vision and neurological system impairment, type II diabetes, and obesity. Therefore, it is important to formulate margarine, low in saturated and trans fats using innovative technologies such as novel hydrogenation, interesterification techniques, and oleogel technology. By utilizing these technologies and oils with a healthy lipid profile, margarine manufacturers are able to produce healthier margarine. This review covers recent technological advancements in margarine, which include various hydrogenation techniques such as high‐voltage atmospheric cold plasma hydrogenation, microwave plasma hydrogenation, dielectric‐barrier discharge plasma hydrogenation, and interesterification based on supercritical CO2 systems. In addition, the application of interesterified oil and oleogel (structured vegetable oils) in the production of margarine low in saturated fat is comprehensively discussed, with emphasis on the utilization of unconventional sources of oils such as tiger nut oil, Moringa oleifera seed oil, Irvingia gabonensis seed fat, winged bean oil, and hemp seed oil. The novel hydrogenation techniques can hydrogenate oils without formation of trans fats, and such hydrogenated oils could be employed in the formulation of trans‐fat‐free margarine. Interesterified oil treated with supercritical CO2 was employed in healthy margarine development. Using the oleogel technique, various unconventional oil sources can be used in margarine formulations. The incorporation of oleogel in margarine makes it possible to improve the lipid profile of margarine due to a reduction in saturated fat content. All of these novel techniques have the potential to revolutionize the margarine industry by enabling the production of high‐quality, healthy margarine.
Simple assay quantifying sediment resuspension effects on marine carbon storage
Authors: Bartl Ines , Evans Tegan , Hillman Jenny , Thrush Simon 
Published: December 2024

Abstract

The seafloor plays a vital role in Earth's climate by storing carbon. However, human activities that disturb the seafloor undermine this function and receive little regulatory attention. This oversight is often due to a lack of empirical data linked to low sampling resolution of the heterogeneous seafloor, highlighting the need for a simple, fast, reproducible quantification approach.

We address this gap by presenting a simple sediment resuspension assay that allows highly replicated sampling of heterogeneous sediments, quantifying the immediate impact on organic carbon mineralization. It is based on biochemical oxygen demand and compares sediment oxygen demand between undisturbed sediment cores and those subjected to resuspension, estimating resuspension‐induced CO₂ production.

Oxygen demand in the resuspension treatment was 2.4–13.4 times higher than in the undisturbed cores, resulting in resuspension‐induced CO₂ production of 210–2064 μmol CO₂ m−2 h−1. This immediate resuspension effect on organic carbon mineralization suggests a substantial impact on organic C stocks that could otherwise contribute to carbon sequestration.

Our assay is notable for its simplicity and accessibility. It offers a critical step towards a more accurate large‐scale assessment of sediment resuspension impacts across the heterogeneous seafloor, evaluating its vulnerability to disturbance and the role of demersal fishing in exacerbating climate change.
A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation‐mediated premature senescence
Authors: Fotopoulou Asimina , Angelopoulou Maria T. , Pratsinis Harris , Mavrogonatou Eleni , Kletsas Dimitris 
Published: December 2024

AbstractUltraviolet B (UVB) radiation is a major contributor to skin photoaging. Although mainly absorbed by the epidermis, UVB photons managing to penetrate the upper dermis affect human dermal fibroblasts (HDFs), leading, among others, to the accumulation of senescent cells. In vitro studies have shown that repeated exposures to subcytotoxic UVB radiation doses provoke HDFs' premature senescence shortly after the end of the treatment period. Here, we found that repetitive exposures to non‐cytotoxic UVB radiation doses after several days lead to mixed cultures, containing both senescent cells and fibroblasts resisting senescence. “Resistant” fibroblasts were more resilient to a novel intense UVB radiation stimulus. RNA‐seq analysis revealed that ERCC6, encoding Cockayne syndrome group B (CSB) protein, is up‐regulated in resistant HDFs compared to young and senescent cells. CSB was found to be a key molecule conferring protection toward UVB‐induced cytotoxicity and senescence, as siRNA‐mediated CSB loss‐of‐expression rendered HDFs significantly more susceptible to a high UVB radiation dose, while cells from a CSB‐deficient patient were found to be more sensitive to UVB‐mediated toxicity, as well as senescence. UVB‐resistant HDFs remained normal (able to undergo replicative senescence) and non‐tumorigenic. Even though they formed a distinct population in‐between young and senescent cells, resistant HDFs retained numerous tissue‐impairing characteristics of the senescence‐associated secretory phenotype, including increased matrix metalloprotease activity and promotion of epidermoid tumor xenografts in immunodeficient mice. Collectively, here we describe a novel subpopulation of HDFs showing increased resistance to UVB‐mediated premature senescence while retaining undesirable traits that may negatively affect skin homeostasis.
Intermittent Short Atrioventricular Delay in a Dual Chamber Pacemaker During Acute Pulmonary Edema
Authors: Vazirani Ravi , García Cocera Miriam , Calvo David 
Published: December 2024

ABSTRACTWe present the case of an 80‐year‐old female with acute pulmonary edema and a dual chamber pacemaker with intermittent short AV delays in the surface ECG after blocked premature atrial contractions (PACs). The behavior was consistent with the programmed Window of Atrial Rate Acceleration Detection (WARAD) and did not require further parameter modifications. As most cardiologists and emergency department physicians are not familiar with brand‐specific algorithms, we believe that this case report will make these noncompetitive atrial pacing algorithms more accessible to non‐cardiologists.
The hidden impact of GLP‐1 receptor agonists on endometrial receptivity and implantation
Authors: Sola‐Leyva Alberto , Pathare Amruta D. S. , Apostolov Apostol , Aleksejeva Elina , Kask Keiu , Tammiste Triin , Ruiz‐Durán Susana , Risal Sanjiv , Acharya Ganesh , Salumets Andres 
Published: December 2024

AbstractIncreasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the rise in infertility. Among several medications used for treating obesity and type 2 diabetes, glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) show promising improvement in female fertility most likely by stimulating ovulation. However, the effects of GLP‐1RAs on the endometrium remain unclear. Further studies are needed to investigate the impact of GLP‐1RAs on endometrial receptivity and embryo implantation and early development. The aim of this study is to address the knowledge gap regarding the effects of GLP‐1RAs on human reproduction, with special focus on the endometrium. Understanding these mechanisms may help to develop new strategies for improving fertility treatment, reduce implantation failure and address potential safety concerns regarding teratogenicity and adverse developmental outcomes for children born to women conceiving during or soon after GLP‐1RA treatment.
Treating asymptomatic follicular lymphoma: What is the score?
Authors: Zammar Ghassan , Cheah Chan Y. 
Published: December 2024

Health‐related quality of life measures are underemphasised in clinical trials and particularly valuable in follicular lymphoma as some interventions can result in substantial toxicity with uncertain impact on overall survival. The report by Marzolini and colleagues provides a nuanced discussion on the merits of rituximab monotherapy versus observation in asymptomatic follicular lymphoma patients.Commentary on: Marzolini et al. Quality of life in advanced‐stage, asymptomatic, non‐bulky follicular lymphoma treated with rituximab shows significant improvement compared with watchful‐waiting. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19918.
STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions
Authors: Liu Zhiruo , Qin Qin , Wang Shisi , Kang Xinmei , Liu Yuxin , Wei Lei , Lu Zhengqi , Cai Wei , Hu Mengyan 
Published: December 2024

ABSTRACTBackgroundMonocyte‐derived macrophages and microglia initially adopt an anti‐inflammatory phenotype following stroke but later transition to a pro‐inflammatory state. The mechanisms underlying this phenotypic shift remain unclear. This study investigates the activation dynamics of molecular signaling pathways in macrophages and microglia after stroke.MethodsWe utilized publicly available single‐cell RNA sequencing datasets to examine the activation dynamics of molecular signaling pathways alongside the pro‐inflammatory phenotype of macrophages and microglia. Male C57BL/6 mice underwent transient middle cerebral artery occlusion (tMCAO), with the STING inhibitor H151 administered to tMCAO mice. Neurobehavioral performance was assessed using rotarod, foot fault, novel object recognition, and water maze tests at 5‐, 7‐, 10‐, and 14‐days post‐stroke. Primary microglia and bone marrow‐derived macrophages were cultured for in vitro experiments.ResultsSingle‐cell sequencing data indicated that the activation of STING and subsequent type I interferon signaling drove the phenotypic shift of microglia and macrophages toward a pro‐inflammatory state in the stroke lesion. Immunostaining demonstrated that the emergence of pro‐inflammatory microglia and macrophages aligned with the activation time course of STING and type I interferon signaling. Continuous phagocytosis by macrophages and microglia led to STING activation, which triggered type I interferon signaling and promoted the phenotypic shift. Inhibition of STING signaling prevented this transition, reduced neuroinflammation, and conferred protection against ischemic stroke.ConclusionThese findings elucidated the critical role of STING‐mediated type I interferon signaling in driving post‐stroke neuroinflammation and underscored the potential of STING inhibition as a therapeutic strategy for alleviating neuroinflammatory responses following stroke.
STING Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis‐Associated Encephalopathy in Mice
Authors: Lv Xin , Jia Min , Feng Xiao , Jian Jia‐xiong , Yang Jian‐jun , Ma Da‐qing , Ji Mu‐huo , Diao Yu‐gang , Shen Jin‐chun 
Published: December 2024

ABSTRACTBackgroundSepsis‐associated encephalopathy (SAE) is a serious neurologic complication in septic patients with poor prognoses. There is increasing evidence that stimulator of interferon genes (STING) plays a crucial role in neuroinflammation and cognitive impairment. However, whether sepsis associated with STING changes contributes to cognitive impairment is unknown.MethodsMale adult mice received lipopolysaccharide (LPS) injection (a single dose of 4 mg/kg; i.p. injection) and 30 min later, they were injected with STING inhibitor C‐176 (a single dose of 30 mg/kg, i.p. injection). Behavioral assessments, biochemical measurements, in vivo and ex vivo electrophysiology techniques were conducted to investigate the association between LPS‐induced STING overexpression and cognitive function.ResultsCognitive impairment was associated with STING overexpression and activation of microglia/macrophages. Phagocytosis of microglia/macrophages as well as complement C1q release were increased after LPS injection, leading to abnormal pruning synapses, synaptic transmission reduction, long‐term potentiation (LTP) impairment, as well as abnormal theta oscillation in the hippocampus. Notably, STING inhibitor C‐176 significantly reversed these changes.ConclusionsSepsis‐induced STING overexpression in microglia/macrophages may lead to synaptic loss, abnormal theta oscillation and LTP impairment through microglia/macrophages activation and complement C1q modulation, ultimately resulting in cognitive impairment.