bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress-strain state of metal in deformation zone during production of steel section billets on the unit of combined continuous casting and deformation. Report 2
Authors: Lekhov O. S. , Mikhalev A. V. 
Published: November 2020

Stress state of metal in deformation zone during introduction of the separating collars of the grooved die into continuously casted steel slab was calculated for production of section billets on the unit of combined continuous casting and deformation. Calculation of axial, tangential and equivalent stresses arising in deformation zone of metal was made in four sections of deformation zone and its results are presented in specific points and lines. View of the section of deformation zone and location of specific points are provided. The stress state of metal in zone of cyclic deformation at formation of three steel section billets from continuously cast slab by separating collars of grooved die on the unit of combined continuous casting and deformation was determined by solving extensive problem of elasticity with the finite element method using the ANSYS package. The results of calculation of axial, tangential and equivalent stresses according to Mises in deformation zone are given in form of graphs and tables for working surfaces in four cross sections. The values and regularities of distribution of these stresses along the length and width of deformation zone were determined. The character of axial stresses distribution by characteristic lines located along the length of deformation zone is shown. Values of the highest compressive and tensile axial stresses arising in deformation zone during introduction of separating collars of grooved were obtained for the unit of combined continuous casting and deformation.
PEMBELAJARAN MATEMATIKA DI LINGKUNGAN NYATA
Authors: Norhidayah Siti 
Published: November 2020

Di latar belakangi oleh permasalahan bahwa pengajaran matematika cenderung membosankan karena pelajaran matematika dianggap hanya mempelajari hal-hal abstrak dengan sederet angka-angka yang dipelajari monoton hanya di dalam kelas. Sudah saatnya pembelajaran matematika dikondisikan dengan lebih menyenangkan, tanpa keterpaksaan dan tentunya tanpa mengabaikan kebermaknaannya. Pemanfaatan lingkungan sebagai media nyata dalam proses pembelajaran matematika tentulah sangat menarik. Hal ini akan lebih efektif jika dimulai dengan membiasakan mahasiswa sebagai calon guru agar berpikir lebih kreatif untuk mengkondisikan lingkungan sekitar baik sebagai sarana, media, bahkan sebagai sumber masalah yang menarik untuk dipecahkan bersama. Banyak obyek nyata di lingkungan sekitar yang bisa diamati secara langsung dan bisa dimanfaatkan untuk meningkatkan pemahaman mahasiswa tentang konsep-konsep matematika.Dengan memanfaatkan lingkungan, mahasiswa akan terbiasa belajar untuk lebih aktif dalam mengembangkan keterampilan berinteraksi dengan lingkungan, mengeksplorasi kemampuan matematisnya, berdiskusi dan menentukan solusi dari permasalahan nyata yang ada di lingkungan sekitarnya.
POLYPHASIC CHARACTERIZATION OF Bacillus STRAINS ISOLATED FROM MAIZE
Authors: GOMES ELIANE APARECIDA , PAULA LANA UBIRACI GOMES DE , RODRIGUES MARINA ELEUTÉRIO GÓI DE MORAES , DE SOUSA SYLVIA MORAIS , OLIVEIRA CHRISTIANE ABREU DE , GUIMARÃES TAVARES AMANDA NAYÊ 
Published: November 2020

The use of bioinoculants with plant growth-promoting bacteria (PGPB) is a sustainable agricultural practice that has been expanding worldwide. Thus, it is fundamental to characterize these bacteria molecularly to provide better security and traceability for bioinoculants production. This work aimed to identify, characterize and develop specific molecular markers for Bacillus strains related to plant-growing promotion. Five strains were identified as B. pumillus (B32), B. thuringiensis (B116), B. megaterium (B119) and B. subitilis (B2082 and B2084) using 16S rRNA gene sequencing and MALDI-TOF mass spectrometry. Repetitive element palindromic (Rep-PCR) and amplified ribosomal DNA restriction analysis (ARDRA) techniques allowed the discrimination of the strains, except B2082 and B2084 that presented identical genetic profiles, indicating that they are same or genetically close isolates. Moreover, specific molecular markers were developed for B116 and B119 strains and may be used for microbial inoculants production quality control, strains traceability and to detail PGPB colonization.
The Potency of Dry-Cooked Rice Waste and Tofu Dregs on Weight Gain and Feed Conversion in Beef Cattle
Authors: Rachma Fianti Nufinda , Hidanah Sri , Sofyan Miyayu Soneta , Setiawan Boedi 
Published: November 2020

Background: Animal feed is one of the main determinants of livestock production costs. Tofu dregs and dry-cooked rice waste is favoured by farmers as an additional feed for cattle because it is readily available and inexpensive. Tofu dregs and dry-cooked rice waste is considered to be able to provide adequate nutrition for cattle and is believed to be able to be a factor in increasing cattle daily body weight. The efficiency of feed use can be determined from feed conversion, namely the amount of feed consumed to achieve an increase of one kilogram of body weight. Purpose: To find out the average increase in daily body weight of beef cattle given tofu dregs and dry-cooked rice waste and how much feed conversion is produced at CV. Tunas Muda Tuban. Method: Using ten beef cattle to be weighed in the first week and the fourth week of observation. Result: Feeding tofu and karak dregs, had an average daily weight gain of 1.34 Kg/day. Conclusion: Provision of tofu and dry-cooked rice waste has a significant influence on the increase in body weight of beef cattle at CV.Tunas Muda, seen from the average daily body weight of 1.34 kg/day.
Aktivitas Antibakteri Ekstrak Metanol Bunga Teratai (Nymphaea pubescens Willd)
Authors: Khairunnisa Amalia , Wathan Nashrul , Fitriana Mia , Fadlilaturrahmah Fadlilaturrahmah , Fiddina Nisriyati 
Published: November 2020

Nymphaea pubescens Willd telah diketahui mempunyai efek antibakteri, terutama pada biji dan daunnya. Tetapi sampai saat ini bagian bunga dari tanaman tersebut belum dilakukan pengujian aktivitas antibakteri. Tujuan dari penelitian ini untuk melakukan skrining fitokimia, uji aktivitas antibakteri dan penentuan konsentrasi hambat minimum (KHM) dari ekstrak metanol bunga N. pubescens terhadap S. aureus dan E. coli. Proses ekstraksi bunga N. pubescens dimaserasi menggunakan pelarut metanol dengan perbandingan 1: 4 b/v. Metode pengujian yang digunakan ada dua yaitu metode difusi untuk pengujian aktivitas antibakteri dan metode dilusi untuk pengukuran konsentrasi hambat minimum (KHM). Hasil skrining fitokimia didapatkan bahwa ekstrak metanol bunga N. pubescens mengandung senyawa golongan fenolik, saponin dan flavonoid. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak metanol bunga N.pubescens mampu menghambat S. aureus (diameter hambat 10 ± 0,29 mm) dan E.coli (diameter hambat 10,2 ± 0,50 mm). Konsentrasi hambat minimum dari ekstrak metanol bunga N. pubescens terhadap S.aureus sebesar 12,5% dan terhadap E.coli sebesar 25%. Dapat disimpulkan bahwa ekstrak metanol bunga N. pubescens memiliki aktivitas sebagai antibakteri. Nymphaea pubescens Willd has known to have antibacterial effects, especially on the seeds and leaves. However, until now the flower of the plant has not been tested for antibacterial activity. The purpose of this study was to perform phytochemical screening, antibacterial activity test and determine the minimum inhibitory concentration (MIC) of the methanol extract of N. pubescens flowers against S. aureus and E. coli. The process of extracting N. pubescens flowers is macerated using methanol as a solvent with a ratio of 1: 4 w / v. There are two test methods used, namely the diffusion method for testing antibacterial activity and the dilution method for measuring the minimum inhibitory concentration (MIC). The results of phytochemical screening showed that the methanol extract of N. pubescens flowers contained phenolic compounds, saponins, and flavonoids. The results of the antibacterial activity test showed that the methanol extract of N.pubescens flowers was able to inhibit S. aureus (inhibition diameter 10 ± 0.29 mm) and E. coli (inhibitory diameter 10.2 ± 0.50 mm). The minimum inhibitory concentration of the methanol extract of N. pubescens flowers against S.aureus was 12.5% and against E. coli was 25%. It can be concluded that the methanol extract of N. pubescens flowers has antibacterial activityKeywords: Nymphaea pubescens, lotus flower, methanol extract, antibacterial
Pemanfaatan Penawar Sampai (Tinospora crispa L.) sebagai Tanaman Obat Tradisional oleh Suku Dayak Ngaju
Authors: Martani Natalia Sri , Fatmaria Fatmaria 
Published: November 2020

Kehidupan sub rumpun Suku Dayak Ngaju di Kalimantan Tengah sangat bergantung pada hutan dan alam. Masyarakatnya menggunakan berbagai obat-obatan tradisional yang bermanfaat, salah satunya adalah tanaman penawar sampai (Tinospora crispa L.). Penelitian ini bertujuan mengeksplorasi tanaman T. crispa sebagai obat tradisional Suku Dayak Ngaju. Metode yang digunakan ialah penelitian eksploratif dari Basir, para ahli pengobatan tradisional Suku Dayak Ngaju. Pemilihan Basir menggunakan metode snowball sampling. Hasil penelitian ini menunjukkan bahwa T. crispa yang digunakan oleh masyarakat Suku Dayak Ngaju secara empiris digunakan sebagai antihipertensi; menunjang diabetes agar terkontrol; pengobatan penyakit kulit; melawan alergi; meningkatkan selera makan; penyembuhan luka; sakit kuning (hepatitis); penyembuhan rematik; antimalaria; menstimulasi saraf; dan antidiare. Kesimpulan penelitian ini bahwa T. crispa merupakan tanaman obat tradisional yang memiliki banyak manfaat. The life of the sub ethnic of Dayak Ngaju Tribe in Central Kalimantan is very dependent on the forest and nature. People use a variety of traditional medicines are beneficial, one of which is the penawar sampai (Tinospora crispa L.). The research objective to explore the utilization of the T. crispa as a medicinal plant traditional Dayak Ngaju Tribe. The method used is exploratory research of Basir, the traditional healers from Dayak Ngaju Tribe. The selection of Basir using the method of snowball sampling. The results of this study indicate that the antidote to that used by the people of Dayak Ngaju Tribe empirically used as an antihypertensive; support to controlled diabetes; a skin disease that can be treated; fight allergies; improves appetite; wound healing; yellow fever (hepatitis); the healing of rheumatism; antimalaria; stimulates the nerves and anti diarrhea. The conclusion of this study that the antidote to is a traditional medicinal plant that has many benefits.Keywords: Penawar Sampai, Tinospora crispa L., Medicinal Plants, Dayak Ngaju Tribe
A construção do conhecimento histórico escolar nos anos iniciais do ensino fundamental: algumas implicações metodológicas
Authors: Malverdes Clara Zandomenico , Salim Maria Alayde Alcântara 
Published: November 2020

Este artigo propõe uma reflexão a respeito de questões sobre a construção do conhecimento histórico escolar nos anos iniciais do ensino fundamental. Neste trabalho abordamos o ensino de História nesta etapa da aprendizagem considerando sua relevância para a formação de uma consciência crítica e descoberta de si como agente de transformação social. Para tanto analisamos a aplicabilidade, em uma escola da rede pública de ensino do município da Serra-ES, de uma metodologia de ensino chamada “Imaginando” que consiste na utilização de imagens produzidas por alunos para representar conceitos trabalhados em sala de aula, com intuito de produzir um conhecimento individual e compreensão do conteúdo proposto. Tendo como metodologia do trabalho a pesquisa participante, abordamos o conceito de tempo, reconhecido como objeto de estudo da história e de importância fundamental na construção do conhecimento histórico. No contexto investigado constata-se a possibilidade do uso da imagem fotográfica como fonte histórica para o trabalho pedagógica, focalizando suas possibilidades para a organização dos conceitos e a compreensão dos conteúdos.
A Didática Reconstrutivista da História: uma proposta teórica e metodológica para o Ensino de História
Authors: Pina Max Lanio Martins , Silva Maria Da Conceição 
Published: November 2020

A resenha apresenta o livro a Didática Reconstrutivista da História publicado em 2020 pela editora CRV, Curitiba, da historiadora e pesquisadora Maria Auxiliadora Moreria dos Santos Schmidt. A presente obra é uma proposta teorica e metodologica para o Ensino de História que está pautado na ciência de referência e buscou influências no pensamento intelectual germânico, anglo-saxônico, ibérico e americano.
Mix of Destinations and Sedentary Behavior Among Brazilian Adults: A Cross Sectional Study
Authors: Florindo Alex Antonio , Turrel Gavin , Garcia Leandro Martin Totaro , Barbosa Joao Paulo dos Anjos Souza , Cruz Michele Santos , Failla Marcelo Antunes , Aguiar Breno Souza , Barrozo Ligia Vizeu , Goldbaum Moises 
Published: November 2020

Abstract
Background: Sedentary behavior is influenced by contextual, social and individual factors, including the built environment. However, associations between the built environment and sitting time have not been extensively investigated in countries with economies in transition such as Brazil. The objective of this study is to examine the relationship between sitting-time and access to a mix of destinations for adults from Sao Paulo city, Brazil. Methods: This study uses data from the Sao Paulo Health Survey. Sedentary behavior was assessed by questionnaire using two questions: total sitting time in minutes on a usual weekday; and on a usual weekend day. Mix of destinations was measured by summing the number of facilities (comprising bus stops, train/subway stations, parks, squares, public recreation centres, bike paths, primary health care units, supermarkets, food stores, bakeries, and coffee-shops) within 500m of each participant’s residence. Minutes of sitting time in a typical weekday and weekend day were the outcomes and mix of destinations score in 500m buffers was the exposure variable. Associations between mix of destinations and sitting time were examined using multilevel linear regression: these models accounted for clustering within census tracts and households and adjusted for environmental, sociodemographic, and health-related factors. Results: After adjustment for covariates, mix of destinations was inversely associated with minutes of sitting time on a weekday (β=-8.8, p=0.001) and weekend day (β=-6.1, p=0.022). People who lived in areas with a greater mix of destinations had shorter average sitting times. Conclusion: Greater mix of destinations within 500m of peoples’ residences were inversely associated with sitting time on a typical weekday and weekend day. In Latin American cities like Sao Paulo built environments more favorable for walking may contribute to reducing sedentary behavior and prevent associated chronic disease.
A Simple, Affordable, Rapid, Stabilized, Colorimetric, Versatile RT-LAMP assay to detect SARS-CoV-2
Authors: Diego Juan García-Bernalt , Fernández-Soto Pedro , Domínghez-Gil Marta , Belhassen-García Moncef , Bellido Juan Luis Muñoz , Muro Antonio 
Published: November 2020

Abstract
The SARS-Cov-2 pandemic has forced all countries worldwide to rapidly develop and implement widespread testing to control and manage the Coronavirus Disease 2019 (COVID-19). RT-qPCR is the gold standard molecular diagnostic method for COVID-19, mostly in automated testing platforms. These systems are accurate and effective, but also costly, time-consuming, high technological, infrastructure dependent and currently suffer from commercial reagent supply shortages. The reverse-transcription loop-mediated isothermal amplification (RT-LAMP) can be used as alternative testing method. Here, we present a novel versatile (real-time and colorimetric) RT-LAMP for the simple (one-step) and rapid (as soon as 9 min) detection of SARS-CoV-2 and demonstrate the assay on RT-qPCR-positive clinical samples. We further transformed the RT-LAMP into a dry format for room-temperature storage suitable for potentially ready-to-use COVID-19 diagnosis. After further testing and validation, the Dry-RT-LAMP could be easily applied both in developed and in low-income countries yielding rapid and reliable results.
Aligning Oxygen Vacancies Oriently: Electric-Field Inducing Conductive Channels in TiO2 Film to boost Photocatalytic Conversion of CO2 into CO
Authors: Li Junming , Su Wenxia , Li Jun , Wang Lu , Ren Jun , Zhang Sheng , Cheng Pengtao , Hong Hong , wang Dunhui , Zhou Yong , Mi Wenbo , Du Youwei 
Published: November 2020

Abstract
Oxide semiconductors are widely used in the photocatalytic fields and introducing oxygen vacancies is an effective strategy to reduce the band gap, and consequently, improve their photocatalytic efficiency. However, oxygen vacancies in bulk often act as the recombination centers of electron-hole pairs, which would accelerate the recombination of electron-hole pairs and reduce carrier migration rate. Therefore, for achieving excellent photocatalytic performance in oxide photocatalysts, taking good advantage of oxide vacancies is very crucial. In this paper, we propose a strategy of electric field treatment and apply it in the TiO2 film with oxygen vacancies to promote the photocatalytic efficiency. After treated by an electric field, conductive channels consisting of oxygen vacancies are formed in TiO2 film, which makes the resistance greatly decreased by almost 6×103 times. In the photocatalytic CO2 reduction reaction, the yield of CO in the electric-field-treated TiO2 film can reach up to 1.729 mmol·gcat-1·h-1, which is one of the best performance among the reported TiO2-based catalysts. This work provides an effective and feasible way for enhancing photocatalytic activity through electric field and this method is promising to be widely used in the field of catalysis.
Anxiety increases the willingness to be exposed to COVID-19 risk among young adults in France
Authors: Etilé Fabrice , Geoffard Pierre-Yves 
Published: November 2020

Abstract
The COVID-19 outbreak has generated significant uncertainty about the future, especially for young adults. Health and economic threats, as well as more diffuse concerns about the consequences of COVID-19, can trigger feelings of anxiety, leading individuals to adopt uncertainty-reducing behaviours. We tested whether anxiety was associated with an increase in willingness to be exposed to the risk of COVID-19 infection (WiRE) using an online survey administered to 3,110 French individuals aged between 18 and 35 years old during the lockdown period (April 2020). Overall, 56.5% of the sample declared a positive WiRE. Unemployment was associated with a higher WiRE (+8.2 percentage points (pp); 95% CI +0.9-15.4 pp). One standard deviation increases in income (+1160€) and psychological state anxiety raised the WiRE by +2.7 pp (95% CI: +1.1-4.4 pp) and +3.9 pp (95% CI: +1.6-6.2 pp),respectively. A one standard deviation increase in perceived hospitalisation risk was associated with a -4.1 pp (95% CI: -6.2-2.1 pp) decrease in the WiRE. Overall, our results suggest that both the prospect of economic losses and psychological anxiety can undermine young adults’ adherence to physical distancing recommendations. Public policies targeting young adults must consider both their economic situation and their mental health, and they must use uncertaintyreducing communication strategies.
Enhanced Anticancer Potency of Hydroxytyrosol and Curcumin by PLGA-PAA Nano-Encapsulation on PANC-1 Pancreatic Cancer Cell Line
Authors: Farhoudi Mahdieh , Shadman Behrouz , Chavoshi Reza , Seyyedsani Nasrin , Aghaei Elnaz , Taheri Elham , Goleij Pouya , Hajazimian Saba , Karamad Vahidreza , Isazadeh Alireza , Baradaran Behzad 
Published: November 2020

Abstract
Background: Pancreatic cancer (PC) is a highly aggressive malignancy associated with low survival rates. Many chemotherapeutic regimens have been investigated for advanced unresectable and metastatic PC, but with only minimal improvement in survival and prognosis. The present study aimed to investigate the anti-cancer function of free and nano-encapsulated hydroxytyrosol (Hyd) and curcumin (Cur), and its combinations (Hyd-Cur) on the PANC-1 cell line.Methods: The poly lactide-co-glycolide-co-polyacrylic acid (PLGA-co-PAA) nano-encapsulated Hyd and Cur were synthesized, and MTT assay was performed to evaluate cytotoxic effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur. Moreover, effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur were evaluated on viability, migration, morphological alterations, colony formation, and apoptosis on PANC-1 cell line. The mRNA expression levels of MMP2, MMP9, BAX, BCL-2, and Cas9 genes were assessed after treated PANC-1 cells with free and nano-encapsulated Hyd, Cur, and Hyd-Cur.Results: The obtained results showed that free and nano-encapsulated Hyd, Cur, and Hyd-Cur treatments significantly decreased the viability, migration, and colony formation in the PANC-1 cells. Furthermore, apoptosis rates in PANC-1 cells were increased in a concentration and time dependent manner in all of the treatment groups. Moreover, anti-proliferative activity of nano-encapsulated Hyd-Cur was significantly more than other treatments.Conclusions: According to our results, Hyd-Cur combination and nano-encapsulation therapy exerts more profound apoptotic and anti-proliferative effects on PANC-1 cell line than free Hyd or Hyd monotherapy.
Analysis of prognostic immune and stromal- related genes in melanoma microenvironment
Authors: Chen Chen , Zhang Chao , Yang Jun-Mei , Guo Jia-Hui , Yin Shan-Shan , Liu Feng , Liu Hua , Gao Feng-Hou 
Published: November 2020

Abstract
Increasing evidence has showed the immune response is an important indicator for predicting therapeutic efficacy, and the prognosis value of the infiltration degree of immune and stromal cells within the tumor microenvironment has been extensively explored. It is necessary to better understand the prognosis value of genes concerning the immune and stromal cells in melanoma patients. A total of 714 up-regulated genes in the high immune and stromal score groups compared with low immune and stromal score groups. Then, a total of 104 hub genes of these differential genes were screened by protein-protein interaction network, and their functional enrichment and signal pathway enrichment analysis showed that they mainly affected tumor microenvironment by cytokine and cytokine receptors interaction, chemokine signaling pathway and T cell receptor signaling pathway involved in regulating Th1, Th2, Th17 differentiation. a single factor risk analysis of survival was performed and found 59 low-risk genes. On this basis, multi-factor risk analysis was carried out, and 10 genes risk model was constructed in TCGA-SKCM. Compared with clinically relevant parameters, the risk models established by these 10 genes showed that these 10 genes could be used as independent factors to predict the prognosis of SKCM patients. The CIBERSORT algorithm was used to calculate immune cell subtypes. In the high-risk group, the infiltration of B cells naïve, monocytes and Macrophages M2 was significantly higher than that in the low-risk group. Finally, we validated these 10 gene in a different melanoma cohort extracted from the GEO database. we identified a list of melanoma immune-related genes that might predict outcomes of melanoma patients. These findings indicated that monitoring and manipulating the melanoma microenvironment could be a promising strategy for precision immunotherapy.