bluuebunny/crossref_metadata_2025_split huggingface dataset:
Realizing doubles: a conjugation zoo
Authors: Pitsch Wolfgang , Scherer Jérôme 
Published: April 2020

AbstractConjugation spaces are topological spaces equipped with an involution such that their fixed points have the same mod 2 cohomology (as a graded vector space, a ring and even an unstable algebra) but with all degrees divided by two, generalizing the classical examples of complex projective spaces under complex conjugation. Spaces which are constructed from unit balls in complex Euclidean spaces are called spherical and are very well understood. Our aim is twofold. We construct ‘exotic’ conjugation spaces and study the realization question: which spaces can be realized as real loci, i.e., fixed points of conjugation spaces. We identify obstructions and provide examples of spaces and manifolds which cannot be realized as such.
Compensation for the Decoherence Effect in Heterodyne Detection of Rough Targets and a Target Vibration Characteristic Measurement System
Authors: Cao Changqing , Su Xiyuan , Liu Yutao , Zeng Xiaodong , Feng Zhejun , Shen Jingshi , Wang Ting , Yan Xu 
Published: April 2020

AbstractIn practical applications of signal detection, the roughness of a target surface significantly affects detection efficiency. In this paper, we propose a signal processing method that improves the sensitivity of a detection system by up to 100 times. In experiments, the target vibration measurement system successfully captured an automotive vibration power spectrum using the proposed signal processing method. This technology opens a new avenue for development in the field of rough surface target detection and recognition.
Predicting Clinical Success in Speech-Language Pathology Graduate Students
Authors: Richardson Lydia , Roberts Elizabeth , Victor Shelley 
Published: April 2020

Purpose
Admissions committees rely heavily on quantitative academic variables such as undergraduate grade point average (UGPA) and scores on the Graduate Record Examination (GRE). However, the ability of these factors to predict the clinical success of speech-language pathology (SLP) graduate students has not been substantiated. The purpose of the current study was to examine the relationship between academic variables (i.e., UGPA, major grade point average, GRE scores) and nonacademic variables (i.e., age, personality type, prior work experience in the field) and determine the degree to which each of these variables predicts clinical success.

Method
Data were extracted from academic records of 45 students enrolled in a graduate SLP program at a public institution of higher learning between 2014 and 2016. Descriptive statistics and correlation coefficients were used to identify the relationships between academic and nonacademic variables with clinical success.

Results
Correlation results did not identify a significant relationship between academic variables and clinical success as well as between nonacademic variables and clinical success. However, relationships between the academic variables and nonacademic variables were discovered. Predictive power of clinical success was not identified due to lack of correlations between the variables.

Conclusions
Academic variables (GRE, UGPA, major grade point average) nor nonacademic variables (age, personality type, previous work experience) were found to have a significant correlation to clinical success in SLP graduate students. There continues to be a lack of evidence in identifying individual variables as sole predictors for success in SLP graduate programs.
Tranexamsäure in den ersten Stunden der Traumaversorgung
Authors: Hofer Stefan , Wolber Martin , Brenner Thorsten 
Published: April 2020

ZusammenfassungIn der klinischen Betrachtung wird die Tranexamsäure (TXA) von vielen Therapeuten als eine Art „Magic Bullet“ bei der präklinischen Behandlung von schwer blutenden Patienten gesehen. Obwohl durch Leitlinien angeraten, wird die generelle Verwendung der TXA im Rahmen des zeitlichen Aspekts der Applikation als auch im Zusammenhang mit speziellen traumaassoziierten Krankheitsbildern wie der traumainduzierten Koagulopathie (TIK) zunehmend kritisch diskutiert.
The ‘Mere Civility’ of Equality Law and Compelled-Speech Quandaries
Authors: Oleske James M 
Published: April 2020

Abstract
When, if ever, do business owners have a right to be exempted from laws prohibiting discrimination in the commercial marketplace? Although public debate over this question often focuses on the issue of religious liberty, litigants seeking exemptions in court have placed equal or greater reliance on arguments about compelled speech. This article examines how such arguments have been employed in recent high-profile cases in both the UK and the USA. The article also addresses a new variation on the exemption argument inspired by Teresa Bejan’s book, Mere Civility, and the allegedly ‘minimal’ conception of civility Roger Williams advocated in the 17th century. After explaining why reliance on Bejan and Williams is misplaced, the article turns to the key questions that arise under modern compelled-speech doctrine when a business owner seeks to resist an equal-service mandate. The US Supreme Court ultimately sidestepped those questions in Masterpiece Cakeshop, Ltd v Colorado Civil Rights Commission, while the UK Supreme Court (UKSC) offered cursory and unsatisfactory answers in Lee v Ashers Baking Co. This article fills the gap with a more thorough analysis.
Registration requirements according to the TVTG (aka the Token Act/Blockchain Act)
Authors: Nägele Thomas 
Published: April 2020

Abstract
The examination of the economic use of blockchain technology and the impact of the so-called token-based economy have enjoyed great popularity in Liechtenstein in recent years. The legal aspect of tokenized structures and assets was a major challenge for the legislator. In order to ensure a solid legal framework and legal certainty for entrepreneurs and users, the Liechtenstein parliament passed the Tokens and Trusted Technology Service Providers Act (“TVTG”). For the first time, a nation has regulated this emerging future market through comprehensive legislation and offers companies optimal framework conditions. The TVTG has been in force since 1 January 2020. This article seeks to outline the legal background for the registration requirements for Trustworthy Technology Service Providers.
Gonadal sex and animal experimentation: Perfection vs. 3R principle?
Authors: Bie Peter , Debrabant Birgit 
Published: April 2020

AbstractReplicability of experimental results and optimal use of experimental animals are everybody's concern. Current efforts towards increased replicability include guidelines and checklists as tools for experimenters, referees, editors and publishers. Guidelines are also provided for appropriate use of animals. To ensure the quality of experimental results, the number of animals must be adequate, that is, sufficiently large, for the purpose of the given experiment. To comply with current ethical recommendations, the use of animals should be reduced as much as possible. Therefore, determination of the number of animals for a given scientific objective includes contrasting considerations. Current guidelines for animal experimentation, notably from the National Institute of Health, mandate (with very few exceptions) inclusion of animals of both sexes in experimental designs statistically powered to address the difference between the two groups. Notably, absence of evidence for sex differences between the organ or system functions under study does not qualify as an exception. Mandatory, equal representation of both sexes raises several questions including ethical ones. Other guidelines, by public regulators and major publishers, do not seem to have a similar selective focus on sex differences. In summary, current concerns about replicability of scientific results are justified. Concomitantly, the knowledge of sex differences also between non‐reproductive, non‐endocrine organ functions is increasing. In principle, sex matters in any experimental context. However, an indiscriminate demand for inclusion of both sexes in all experimental protocols seems a waste of animals, money and time, violating traditional principles of animal experimentation, particularly that of reduction.
Novel implantable pressure and acceleration sensor for bladder monitoring
Authors: Soebadi Mohammad Ayodhia , Weydts Tristan , Brancato Luigi , Hakim Lukman , Puers Robert , De Ridder Dirk 
Published: April 2020

ObjectivesTo test the hypothesis that an implantable sensing system containing accelerometers can detect small‐scale autonomous movements, also termed micromotions, which might be relevant to bladder physiology.MethodsWe developed a 6‐mm submucosal implant containing a pressure sensor (MS5637) and a triaxial accelerometer (BMA280). Sensor prototypes were tested by implantation in the bladders of Gottingen minipigs. Repeated awake voiding cystometry was carried out with air‐charged catheters in a standard urodynamic set‐up as comparators. We identified four phases of voiding similar to cystometry in other animal models based on submucosal pressure. Acceleration signals were separated by frequency characteristics to isolate linear acceleration from the baseline acceleration. The total linear acceleration was calculated by the root mean square of the three measurement axes. Acceleration activity during voiding was investigated to adjacent 1‐s windows and was compared with the registered pressure.ResultsWe observed a total of 19 consecutive voids in five measurement sessions. A good correlation (r > 0.75) was observed between submucosal and catheter pressure in 14 of 19 premicturition traces. The peak‐to‐peak interval between maximum total linear acceleration was correlated with the interval between submucosal voiding pressure peaks (r = 0.760, P < 0.001). The total linear acceleration was higher during voiding compared with pre‐ and postmicturition periods (start of voiding/phase 1).ConclusionsTo the best of our knowledge, this is the first report of bladder wall acceleration, a novel metric that reflects bladder wall movement. Submucosal sensors containing accelerometers can measure bladder pressure and acceleration.
N-acetylcysteine resists high-glucose-induced injury of human umbilical vein endothelial cells by inhibiting the leptin/leptin receptor
Authors: Wang Zhenhua , Chen Jun , Lian Shuping , Liao Kaibin , Huang Lizhi , Li Chaosheng 
Published: April 2020

Abstract
Background The present study aimed to investigate whether N- acetylcysteine (NAC) protects human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced injury by inhibiting leptin/leptin receptor (LEPR). Methods HUVECs were treated with 40 mmol/L glucose for 24 h to establish a model of HG-induced endothelial cell injury; The cell viability was examined by cell counter kit-8 (CCK-8) assay; The expression levels of leptin, LEPR, cleaved caspase-3 and endothelial nitric oxide synthase (eNOS) were detected by western blot. The intracellular levels of reactive oxygen species (ROS) were tested by DCFH-DA staining followed by photofluorography. Tumor necrosis factor-α (TNF-α)、nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) were detected by enzyme-linked immunosorbent assay (ELISA). The number of apoptotic cells was observed by photofluorograph with Hoechst 33258 nuclear staining. Mitochondrial membrane potential (MMP) was obtained using JC-1.Results The expression of leptin and LEPR began to significantly increase after exposure to 40 mmol/L HG for 24 h. Pretreatment of HUVECs with 7 mmol/L NAC or 50 ng/mL leptin antagonists (LA) for 30min inhibited the increased expression of leptin and LEPR induced by HG in HUVECs. Furthermore, pretreatment with 7 mmol/L NAC or 50 ng/mL LA for 30 min also inhibited HG-induced injury, by increasing the cell viability and eNOS expression, and decreasing the inflammatory response and cleaved caspase-3 expression, the apoptotic cells and generation of intracellular ROS and a loss of MMP. Conclusions NAC protects the HUVECs against HG-induced injury by inhibiting leptin/LEPR.
Multi-center investigation on personnel training and scientific research status of pharmacy intravenous admixture services (PIVAS) in mainland China based on the perspectives of PIVAS leaders
Authors: Yang Chunsong , Lin Yunzhu , Zhao Li , Zhang Lingli 
Published: April 2020

Abstract
Background: We sought to analyze the current situation of personnel training and scientific research regarding pharmacy intravenous admixture services (PIVAS), to provide evidence-based medical knowledge to inform personnel training for PIVAS in mainland China.Methods: A cross-sectional survey was used to examine the current status of PIVAS personnel training, research capabilities, needs, and research output of PIVAS personnel based from the perspective of leaders in PIVAS in China. The survey period was from March to April 2019.Results: A total of 137 hospitals in China participated in this survey. The main training content areas of PIVAS staff in each hospital were professional theoretical knowledge (100.00%, 137/137) and practical operation ability (98.54%, 135/137). The frequency of training was typically 1–2 times/month (56.9%, 78/137). The average duration of a single training session was typically 1 hour or less (68.6%, 94/137). The most common forms of PIVAS training were lectures (94.89%, 130/137) and practical operations (79.56%, 109/137). A total of 51.8% (71/137) of PIVAS leaders believed that PIVAS personnel had a high degree of scientific research needs, but 61.3% (84/137) believed that few personnel had mastered scientific research methodology, and 41.6% (57/137) believed that the scientific research ability of personnel was relatively poor. Among PIVAS personnel, only 38.7% (53/137) had specialized scientific training. The annual SCI output was 0–18 articles (median 0 articles) and the number of national-level funding grants was 0–2 (median 0). There were no significant differences in the training of PIVAS personnel and scientific research between different provinces and hospital levels.Conclusions: The training content of PIVAS personnel in China was found to be relatively rich, but management tools, career development, and training in scientific research were found to be relatively weak, and the scientific research output was very low. It is necessary to build a comprehensive training system for career development among PIVAS personnel.
Characterization of Tn7-like transposons and its related antibiotic resistance among Enterobacteriaceae from livestock and poultry in China
Authors: He Juan , Li Cui , Cui Pengfei , Wang Hongning 
Published: April 2020

Abstract
Background: This study was aimed to investigate the prevalence and structure of Tn7-like in Enterobacteriaceae from livestock and poultry as well as their possible role as reservoir of antibiotic resistance genes (ARGs).Methods: Polymerase chain reaction (PCR) and DNA sequencing analyses were used for the characterization of Tn7-like, associated integrons and ARGs. The antimicrobial resistance profile of the isolates was examined by using disc diffusion test.Results: Three hundred and seventy-eight Tn7-like-positive strains of Enterobacteriaceae were isolated, and included E. coli (128), Proteus(150), K. pneumonia(17), Salmonella(13), M. morganii (21) and A. baumannii(1), wherein high resistance was observed for Trimethoprim/Sulfamethoxazole and Streptomycin, and fifty percent of the strains were multidrug-resistant. Integrons class 2 were detected in all of the isolates and there are high frequency mutation sites especially in 535, a stop mutation. Variable region of class 2 integrons carried same gene cassettes, namely aadA1-sat2-dfrA1. From the 378 isolated strains, we found a new type of Tn7-like on a plasmid, named Tn6765.Conclusions: These findings proved that the Tn7-like can contribute to the horizontal transmission of antibiotic resistant genes in livestock and poultry. As potential vessels for antibiotic resistance genes (ARGs), Tn7-like could not be ignored due to their efficient transfer ability in environments.
Effect of surface charge of nanohybrids on the intracellular bacterial killing efficiency
Authors: Bose Rajendran JC , Tharmalingam Nagendran , Choi Yonghyun , Madheswaran Thiagarajan , Paulmurugan Ramasamy , McCarthy Jason , Lee Soo-Hong , Park Hansoo 
Published: April 2020

Abstract
Background : Lipid polymer hybrid nanoparticles (LPHNPs) are widely investigated nanohybrid system in drug and gene delivery and also medical imaging. A knowledge of lipids-based surface engineering and its effects on the physicochemical properties of LPHNPs affect the cell – NPs interaction, consequently, influence the cytological response is in high demand.Methods and Results : Herein, we developed a cationic and zwitterionic lipids-based surface engineering approach with antibiotics (Doxycycline or Vancomycin) loaded LPHNPs and examined the surface charge influence on the physiochemical characteristics, antibiotic entrapment, and intracellular release behaviors. Importantly, we examined the intracellular antibacterial activity of drug-loaded LPHNPs against Mycobacterium smegmatis or Staphylococcus aureus infected macrophages. Furthermore, cationic or zwitterionic lipids in LPHNP formulations improved the antibiotic loading efficiency and extended the duration of antibiotic release. In vitro particle uptake studies indicated that the cationic LPHNPs and bare nanoparticles (BNPs) were more efficiently internalized into macrophages than zwitterionic LPHNPs.Conclusion : A play in surface charge in the formulation of the macrophage uptake and intracellular bacterial killing efficiency of LPHNPs loaded with clinical antibiotics on macrophages infected with bacteria, provided a basis for optimizing their use in biomedical applications.
Obras de Maurice Merleau-Ponty
Authors: Arias García Benito 
Published: April 2020

RESUMENInforme bibliográfico de las obras de Maurice Merleau-Ponty hasta 1996, que revisa y actualiza repertorios anteriores. El informe incluye también trabajos inéditos y documentos de su legado personal.PALABRAS CLAVEMERLEAU-PONTY-FILOSOFIA FRANCESA-FENOMENOLOGIAABSTRACTBibliographical report of Maurice Merleau-Ponry's works up to 1996, wich revises and updates previous bibliographies. The report also includes unpublished papers and documents from his personal legacy. KEYWORDSMERLEAU-PONTY- FRENCH PHILOSOPHY-PHENOMENOLOGY
Analisis Faktor-faktor yang Berpengaruh Terhadap Pencegahan Fraud di Dalam Proses Pengadaan Barang dan Jasa (Riset Empiris pada Direktorat Jenderal Pengelolaan Ruang Laut KEMENTRIAN KELAUTAN dan PERIKANAN)
Authors: Larasati Yarry Septia , Surtikanti Surtikanti 
Published: April 2020

Semakin pesatnya perkembangan perekonomian di dunia memberikan banyak manfaat bagi masyarakat tetapi juga diiringi dengan semakin berkembangnya fraud atau biasa dikenal dengan istilah kecurangan Kasus korupsi yang ditangani Komisi Pemberantasan Korupsi (KPK), 70 persen diantaranya merupakan kasus pengadaan barang dan jasa. Penelitian ini bertujuan untuk mendapatkan data empiric tentang seberapa besar pengaruh Peran Pengendalian Internal, Whistleblowing System, dan Good Governance baik secara parsial maupun simultan terhadap Pencegahan Fraud. Penelitian ini melibatkan 53 responden lingkup Direktorat Jenderal Pengelolaan Ruang Laut Kementerian Kelautan dan Perikanan. Penelitian ini menggunakan metode survey dengan kuesioner sebagai instrument penelitian. Hasil penelitian ini menunjukan bahwa terdapat pengaruh positif dan signifikan Peran Pengendallian Internal, Whistleblowing System dan Good Governance baik secara parsial maupun simultan terhadap Pencegahan Fraud.
Kata Kunci : Pengendalian Internal, Whistleblowing System, Good Corporate Governance, dan Pencegahan Fraud
Implementasi Model Pembelajaran Berbasis Multimedia Interaktif Untuk Meningkatkan Hasil Belajar Dan Keterampilan Berfikir Kritis Siswa SMK
Authors: Ismail Ali , Gumilar Surya 
Published: April 2020

Abstract— Pada saat ini kita juga sedang memasuki era informasi. Teknologi dan komunikasi (TIK) yang terus berkembang dan cenderung akan terus mempengaruhi segenap kehidupan manusia. Perkembangan TIK ini memungkinkan dihasilkannnya berbagai multimedia dalam pembelajaran yang dapat memudahkan dan membangkitkan motivasi belajar siswa dalam mempelajari konsep Fisika. Penelitian ini menggunakan metode kuasi eksperimen (eksperimen semu). Desain eksperimen yang digunakan adalah The randomized Pretest-Posttest control group design. hasil penelitian menunjukan bahwa penggunaan model pembelajaran berbasis multimedia interaktif dapat lebih meningkatkan Hasil belajar siswa dibandingkan pembelajaran dengan pembelajaran konvensional. Sedangkan data keterampilan berfikir kritis menunjukan rata-rata gain yang dinormalisasi untuk kelas eksperimen ialah 0,66 dan nilai rata-rata gain yang dinormalisasi untuk kelas kontrol ialah 0,44 dengan kategori sedang. Perbandingan nilai ini secara langsung menunjukkan bahwa penggunaan model pembelajaran berbasis multimedia interaktif dapat lebih efektif meningkatkan keterampilan kritis siswa dibandingkan dengan pembelajaran konvensional. Keywords— Hasil Belajar, Keterampilan berfikir kritis, multimedia interaktif
Структурно-логическая модель управления чрезвычайной ситуацией террористического характера и ее особенности, обусловленные скрытым электромагнитным воздействием на оперативный состав охраняемого объекта критической инфраструктуры
Authors: Azarenko Elena , Honcharenko Yulia , Divizinyuk Mykhailo , Mirnenko Volodymyr , Syrytsia Iuliia 
Published: April 2020

Главная цель управления чрезвычайной ситуацией – это недопущение катастрофического события, вокруг которого она развивается, а в случае его (катастрофического события) наступления – минимизация ущерба и возможных последствий. Структурно-логическая модель управления чрезвычайной ситуацией состоит из шести блоков. Это мониторинг ситуации (сбор повседневных факторов), выявление риска возникновения чрезвычайной ситуации (обнаружение экстремального фактора), анализ риска (прогноз и моделирование чрезвычайной ситуации), подготовка вариантов управленческих решений, принятие решения и доведение его исполнителям, воздействие на ситуацию, которое через структуру исполнителей влияет на объект управления и замыкает контур управления. Этим обеспечивается непрерывность процесса управления чрезвычайной ситуацией террористического характера в интересах ее недопущения и предотвращения.
Особенностью электромагнитного воздействия на персонал охраняемых объектов критической инфраструктуры является его скрытность и долгосрочное сохранение результатов воздействия. Это в свою очередь может привести к ошибкам персонала, который обеспечивает главный технологический процесс охраняемого объекта, и привести к техногенному катастрофическому событию.
Для противодействия подобным террористическим действиям необходимо разработать и внедрить определенные мероприятия, которые будем называть особенностями структурно-логической модели управления чрезвычайной ситуацией террористического характера на охраняемом объекте критической инфраструктуры.В работе на основе анализа обобщенной структурно-логической модели управления чрезвычайной ситуацией террористического характера на охраняемом объекте критической инфраструктуры и характеристик скрытого электромагнитного воздействие на персонал охраняемого объекта, определяются факторы, обуславливающие особенности структурно-логической модели управления чрезвычайной ситуацией террористического характера на охраняемом объекте критической инфраструктуры, вызванные скрытым электромагнитным воздействием на оперативный (управленческий) состав объекта.