bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary arterial hypertension associated with interferon therapy: a population-based study
Authors: Papani Ravikanth , Duarte Alexander G. , Lin Yu-li , Kuo Yong-Fang , Sharma Gulshan 
Published: January 2020

Background: Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are available. The aim of this study was to determine the incidence of PAH after initiation of interferon therapy, using a large commercial insurance database.
Methods: Using National Drug Codes (NDCs) and Healthcare Common Procedure Coding System (HCPCS) codes, we utilized the Clinformatics™ Data Mart (CDM) database to identify subjects between 20 and 65 years old who received α or β interferon therapy between April 2001 and December 2012. Patients were followed from one year prior to the first medication claim for interferon to the first diagnosis of pulmonary hypertension using ICD-9-CM codes 416.0 and 416.8, or disenrollment. In those subjects diagnosed with pulmonary hypertension, a prescription for PAH-specific medications was used as a surrogate endpoint.
Results: We identified 20,113 subjects who received interferon therapy during the study period. The median follow-up was 20 months. Pulmonary hypertension occurred in 71 subjects, and PAH-specific medications were prescribed to 7 of these subjects.
Conclusion: Although our analysis showed that the development of PAH is a rare event with
Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice
Authors: Stellari Franco Fabio , Ruscitti Francesca , Ravanetti Francesca , Essers Jeroen , Ridwan Yanto , Belenkov Sasha , Vos Wim , Ferreira Francisca , KleinJan Alex , Van Heijningen Paula , Van Holsbeke Cedric , Cacchioli Antonio , Villetti Gino 
Published: January 2020

Background: The intratracheal instillation of bleomycin in mice induces early damage to alveolar epithelial cells and development of inflammation followed by fibrotic tissue changes and represents the most widely used model of pulmonary fibrosis to investigate human IPF. Histopathology is the gold standard for assessing lung fibrosis in rodents, however it precludes repeated and longitudinal measurements of disease progression and does not provide information on spatial and temporal distribution of tissue damage. Here we investigated the use of the Micro-CT technique to allow the evaluation of disease onset and progression at different time-points in the mouse bleomycin model of lung fibrosis. Micro-CT was throughout coupled with histological analysis for the validation of the imaging results.
Methods: In bleomycin-instilled and control mice, airways and lung morphology changes were assessed and reconstructed at baseline, 7, 14 and 21 days post-treatment based on Micro-CT images. Ashcroft score, percentage of collagen content and percentage of alveolar air area were detected on lung slides processed by histology and subsequently compared with Micro-CT parameters.
Results: Extent (%) of fibrosis measured by Micro-CT correlated with Ashcroft score, the percentage of collagen content and the percentage of alveolar air area (r2 = 0.91; 0.77; 0.94, respectively). Distal airway radius also correlated with the Ashcroft score, the collagen content and alveolar air area percentage (r2 = 0.89; 0.78; 0.98, respectively).
Conclusions: Micro-CT data were in good agreement with histological read-outs as micro-CT was able to quantify effectively and non-invasively disease progression longitudinally and to reduce the variability and number of animals used to assess the damage. This suggests that this technique is a powerful tool for understanding experimental pulmonary fibrosis and that its use could translate into a more efficient drug discovery process, also helping to fill the gap between preclinical setting and clinical practice.
Erratum to: The evidence on tiotropium bromide in asthma: from the rationale to the bedside
Authors: Radovanovic Dejan , Santus Pierachille , Blasi Francesco , Mantero Marco 
Published: January 2020

After publication of the Review article it was brought to our attention that the sentence at the bottom of the
section entitled Tiotropium bromide must be corrected as follows:
“Following positive large efficacy and safety trials in asthma, in 2014 the European Medicines Agency has extended the indication of tiotropium Respimat®....
Non-typeable Haemophilus Influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease
Authors: Sriram Krishna B. 
Published: January 2020

Background: Chronic airway inflammation and hypersensitivity to bacterial infection may contribute to lung cancer pathogenesis. Previous studies have demonstrated that nontypeable Haemophilus influenzae (NTHi) is the most common colonizing bacteria in the lower airways of patients with COPD. The objective of this study was to determine the presence of NTHi and immunoglobulin concentrations in patients with lung cancer, COPD and controls. Methods: Serum and bronchial wash samples were collected from patients undergoing diagnostic bronchoscopy. Total IgE, IgG and specific NTHi IgG were measured by enzyme linked immunosorbent assay. Bronchial wash samples were examined for the presence of NTHi via PCR. Results: Out of the 60 patients: 20 had confirmed Lung Cancer, 27 had COPD only and 13 were used as Controls. NTHi was detected in the lower airways of all three groups (Lung Cancer 20%; COPD 22% and Controls 15%). Total IgE was highest in Lung Cancer subjects followed by COPD and control subjects (mean ± SD: 870 ± 944, 381 ± 442, 159 ± 115). Likewise total IgG was higher in Lung cancer (Mean ± SD: 6.99 ± 1.8) patients compared to COPD (Mean ± SD: 5.43 ± 2). Conclusions: The lack of difference in NTHi and specific antibodies between the three groups makes it less likely that NTHi has an important pathogenetic role in subjects with Lung Cancer. However the detection of higher IgE antibody in Lung Cancer subjects identifies a possible mechanism for carcinogenesis in these subjects and warrants further study.
Delay and inequalities in the treatment of idiopathic pulmonary fibrosis: the case of two Nordic countries
Authors: Pesonen Ida , Carlson Lisa , Murgia Nicola , Kaarteenaho Riitta , Sköld Carl Magnus , Myllärniemi Marjukka , Murgia Giovanni 
Published: January 2020

Background: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive loss of lung function with high mortality within the first 5 years from diagnosis. In 2011–2014, two drugs, pirfenidone and nintedanib, have been approved worldwide for prevention of IPF progression. National IPF-registries have been established in both Finland and Sweden. Our study explored potential differences in the care of IPF in these two countries.
Methods: Patients included consecutively in the Finnish and Swedish IPF-registries from January 1, 2014 through December 31, 2016 were included in the study. Data on demographics and lung function at the time of inclusion were collected. Access to antifibrotic drugs and data on disease outcomes, mortality and the proportion of patients who underwent lung transplantation, was collected during a 3-year follow up.
Results: One-hundred and fifty-two patients from the Finnish and 160 patients from the Swedish IPF-cohorts were included in the study. At inclusion, Finnish patients were significantly older than the Swedish patients (74.6 years vs 72.5 years, p = 0.017). The proportion of non-smokers was significantly higher in the Finnish cohort (41.7% vs 26.9%, p = 0.007). Forced vital capacity (FVC), % of predicted (78.2 vs 71.7 for Finnish and Swedish patients, respectively, p = 0.01) and diffusion capacity for carbon monoxide (DLCO), % of predicted (53.3 vs 48.2 for Finnish and Swedish patients, respectively, p = 0.002) were significantly higher in the Finnish cohort compared to the Swedish cohort at the time of inclusion. During the 3-year follow up period, 45 (29.6%) Finnish and 111 (69.4%) Swedish patients, respectively, were initiated on treatment with an antifibrotic drug (pirfenidone or nintedanib) (p < 0.001). When comparing possible determinants of treatment, patients with higher FVC % were less likely to start antifibrotic drugs (OR 0.96, 95%CI 0.93–1.00, p < 0.024). To be resident in Sweden was the main determinant for receiving antifibrotic drugs (OR 5.48, 95%CI 2.65–11.33, p < 0.0001). No significant difference in number of deaths and lung transplantation during the follow up period was found.
Conclusions: This study highlights differences concerning how IPF patients are treated in Finland and Sweden. How these differences will influence the long-term outcome of these patients is unknown.
Correction to: Fluticasone furoate/Vilanterol 92/22 μg once-a-day vs Beclomethasone dipropionate/Formoterol 100/6 μg b.I.D.: a 12-month comparison of outcomes in mild-to-moderate asthma
Authors: Dal Negro Roberto W. , Bonadiman Luca , Turco Paola 
Published: January 2020

Correction to: Multidisciplinary Respiratory Medicine (2018) 13:18 DOI: 10.1186/s40248-018-0131-x
After publication of the Original research article [1] it was brought to our attention that the sentence at pag 6 (between Fig. 3 and Fig. 4)) must be corrected as follows: “The mean duration of inactivity was 2.88 (0.63) at baseline; 1.53 (0.27) after 3; 1.40 (0.27) after 6, and 1.45 days (0.58) after twelve months (Anova: p = 0.11) in group A, while the corresponding duration in group B was 3.35 (0.63) at baseline; 0.60 (0.19) after 3; 1.10 (0.21) after 6, and 0.83 days (0.39) after 12 months (Anova; p <0.001), respectively.” In addition at pag. 7 Fig. 5 entitled “Changes in mean duration of inactivity/p. over 12 months” must be substituted with the new Fig. 5 because there is a mistake regarding anova p = 0.11 and consequently in the whole image. This Correction shows the revised Fig. 5. The original article has been updated.
Effect of Low Velocity Impact at Pre-Stressed Condition on Curved Glass-Carbon Composites Laminate
Authors: Asokan R. , Balaji H. , Rubanrajasekar B. , Dinesh M. 
Published: January 2020

A curved composite panel is used in aircraft parts such as wings and engine cowling in order to improve their impact resistance to different types of impact loads. The effect of size reduction in the tensile pre-stress behaviour of low velocity impact on different materials such as glass and glass/carbon hybrid is examined in this paper. The effects of low velocity impact behaviour of two different pre-stressed curved laminates are taken for consideration and examined under impact loading. The objective of this research is to improve the efficiency of curved laminate by changing the hybrid composition such as glass/carbon with varied stacking sequence.	The present studies using hybrid composition have shown that the load carrying capacity is higher in convex laminates while the damaged surface area in convex laminates is very less.
Platelet reactivity expressed as a novel platelet reactivity score is associated with higher inflammatory state after coronary artery bypass grafting
Authors: Wilczyński Mirosław , Krejca Michał , Stepinski Piotr , Rozalski Marcin , Golanski Jacek 
Published: January 2020

IntroductionDespite therapy, patients operated using a cardiopulmonary bypass demonstrate increased platelet aggregation, which rebounds to above preoperative levels. The aim of the study was to test the interaction between platelet reactivity/activation and selected inflammatory markers in the post-operative period.Material and methodsIn total, 103 patients with non-ST elevation acute coronary syndrome (NSTE-ACS) who were not eligible for percutaneous coro­nary interventions (PCI), and required urgent revascularization, were included. Platelet reactivity was measured using the PFA-100 platelet analyser, multiple electrode aggregometry, and was expressed as a novel platelet reactivity score (PRS). Patients were divided using their PRS scores into high platelet relativity or low platelet reactivity subgroups (HPR or LPR). Platelet basal activation was measured using immunoassays for soluble P-selectin and soluble CD40L. We measured high-sensitivity C-reactive protein (CRP), and used immunoassays for tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) as inflammation markers.ResultsSignificant differences between HPR and LPR groups were found for CRP (mg/l): 81.5 vs. 44.6, p < 0.02; and TNF-α (pg/l): 3.51 vs. 2.37, p < 0.02. A significant association was found between CRP, TNF-α, IL-6 and platelet reactivity (platelet reactivity score). Cohen’s  showed: CRP = 0.49, p < 0.0001, TNF-α = 0.37, p < 0.002. Perioperative myocardial infarction and rhythm disturbances occurred more frequently in the high platelet reactivity group: 7 (16.3%) vs. 2 (3.3%), p < 0.04, and 9 (20.9%) vs. 4 (6.7%), p < 0.04, respectively.ConclusionsInflammatory parameters CRP and TNF-α are strongly associated with platelet reactivity (expressed as PRS) in cardiopulmonary bypass graft patients. Platelet hyperreactivity in the early post-operative period combined with a systemic inflammatory state correlates with a higher risk of post-operative rhythm disturbances and myocardial infarction.
Histopathological changes in myocardial tissue due to coronary venous hypertension
Authors: Akşit Ercan , Büyük Başak , Oğuz Sonay 
Published: January 2020

IntroductionIn chronic venous insufficiency (CVI), an increase in venous pressure causes the passage of intravascular blood cells and molecules into the surrounding tissues and induces histopathological changes in the lower extremities, leading to increased pigmentation in the legs, ulceration, and tissue loss to various degrees. This study aimed to investigate whether an increase in venous pressure in the coronary veins can lead to the aforementioned histopathological changes.Material and methodsTwenty-four New Zealand rabbits were divided into the following three groups: experimental model of coronary venous hypertension (CVH) (n = 8), sham group (n = 8), and control group (n = 8). After 21 days postoperatively, tissue samples from each group were compared for perivascular inflammation, erythrocyte extravasation, macrophage infiltration, and hemosiderin deposits by histopathological scoring under a light microscope. Matrix metalloproteinase-2 (MMP-2) activation was evaluated using immunohistochemical staining.ResultsIn the CVH group, hemosiderin accumulation was significantly higher than in the sham and control groups (1.0 (1.0–3.0), 0.0 (0.0–1.0), 0.0 (0.0–0.0); p < 0.001). Immunohistochemically, in the CVH group, MMP-2 levels were significantly higher than in the sham and control groups (2.0 (1.0–3.0), 0.0 (0.0–1.0), 0.0 (0.0–0.0); p < 0.001).ConclusionsThis experimental study showed for the first time the histopathological and immunohistochemical changes in myocardial tissue, similar to those observed in CVI, as a result of increased coronary venous pressure due to coronary vein ligation. Further studies are needed to understand the clinical implications of these results.
Left atrial volume index predicts response to cardiac resynchronisation therapy: a systematic review and meta-analysis
Authors: Bytyçi Ibadete , Bajraktari Gani , Henein Michael 
Published: January 2020

IntroductionIn responders, cardiac resynchronisation therapy (CRT) results in improved left ventricular (LV) function and reduced atrial arrhythmia. The aim of this meta-analysis was to assess the potential relationship between the left atrium (LA) volume and CRT response.Material and methodsWe systematically searched all electronic databases up to August 2018 in order to select clinical trials and observational studies that assessed the predictive value of LA volume index (LAVI) of CRT response. Left ventricular end-systolic volume (LVESV) reduction ≥ 15 ml and/or LV ejection fraction (EF) increase ≥ 10% were the documented criteria for positive CRT response.ResultsA total of 2191 patients recruited in 10 studies with mean follow-up duration of 10.5 months were included in this meta-analysis. The pooled analysis showed that CRT responders had lower baseline LAVI compared to non-responders, with a weighted mean difference (WMD) of –5.89% (95% CI: –9.47 to –3.22, p < 0.001). At follow-up, LAVI fell in the CRT responders (WMD –4.36%, 95% CI: –3.54 to –5.17, p < 0.001) compared to non-responders (WMD 1.45 %, 95% CI: –0.75 to 3.65, p = 0.20). The mean change of LAVI in the CRT responders was related to the fall in LVESV,  = –1.02 (–1.46 to –0.58), p < 0.001 and the increase in LVEF,  = 2.02 (1.86 to 4.58), p = 0.001. A baseline LAVI < 34 ml/m2 predicted CRT response with summary sensitivity 0.80% (0.53–0.95), specificity 0.74% (0.53–0.89), and odds ratio > 11.ConclusionsBaseline LAVI predicts CRT response, and its reduction reflects devise-related LA remodelling. These results emphasis the role of LAVI assessment as an integral part of cardiac function response to CRT.
Locus of control in situations of successes and failures and personality traits in young athletes practicing team sports
Authors: Filipiak Sara , Łubianka Beata 
Published: January 2020

BackgroundThe aim of this study was to analyze locus of control in situations of successes and failures and personality traits in young people attending sport and non-sport classes. Based on a review of studies, it was presumed that young people who practice team sports have a higher internal locus of control, higher openness to experi-ence, higher conscientiousness, and higher emotional stability than their peers who do not practice sport.Participants and procedureYoung people who took part in the study were both those who attended schools with sport education programs and those who attended non-sport schools. 63 students of the sixth grade of primary school and the first grade of junior high school were surveyed (M = 12.60). Two groups were distinguished: students who followed an extended sports curriculum practicing football and basketball (n = 31), and those who followed a standard cur-riculum (n = 32). The Questionnaire for Locus of Control and the Picture Based Personality Survey for Children, based on the Big Five model, were used in the analyses.ResultsThe results of the studies partially confirmed the assumed hypotheses and showed connections between locus of control in situations of failure and openness to experience in the group of athletes.ConclusionsThis study constitutes a summary of the first stage of a three-year longitudinal project. Conclusions from the study will allow characterization of developmental changes of locus of control and personality traits in young athletes. Assessment of personality profile constitutes help for sport psychology practitioners in preparing train-ing that uses accurate reinforcement systems corresponding with the traits of players that are members of a team.
Bebidas e comidas em celebrações de nascimento e morte: um estudo em comunidades rurais de Sergipe e Bahia
Authors: Menezes Sônia Souza , Bertoni Luci Mara , Santos Rosangela Vasconcelos Raimundo 
Published: January 2020

Em algumas comunidades rurais do Brasil, encontramos traços culturais que estão enraizadas no modo de vida de determinadas populações, as quais perpetuam tradições e identificam particularidades vivenciadas em momentos relevantes da sua história. Esses acontecimentos são celebrados e compartilhados entre a família, vizinhos e amigos. Estes sujeitos sociais constroem suas memórias, representações e histórias a partir da relação com as atividades e heranças compartilhadas no encontro entre os tempos curtos e os tempos longos no espaço rural. Ancorado nessa compreensão, o propósito desse estudo consiste em analisar a dimensão simbólica das comidas e bebidas nas celebrações de nascimento e morte em comunidades rurais dos estados de Sergipe e Bahia. Além da revisão teórica, foram realizadas entrevistas em comunidades rurais do estado de Sergipe e Bahia no período de maio de 2016 a janeiro de 2017. Embora não haja relação explícita entre essas comunidades, pudemos perceber muitas semelhanças entre elas na forma de celebrar, no preparo das bebidas e comidas que fazem parte destes rituais que se perpetuam por gerações.
Palavras-chave: Comunidades rurais; bebidas e comidas; celebrações nascimento e morte.
Negacionismos e Histórias Públicas Reacionárias: Os usos abusivos do passado em tempos de pós-verdade
Authors: Meneses Sônia 
Published: January 2020

Resumo: Este artigo problematiza a emergência de histórias públicas reacionárias e novos negacionismo influenciados pela profusão de narrativas históricas vinculadas aos meios de comunicação e às ideias de pós-verdade. Assim, destacam-se as relações entre história e abusos do passado, difusão de narrativas históricas e consumo. Ao final, aponta para os desafios colocados ao próprio lugar da produção histórica e dos historiadores frente a essa produção.
Palavras-chave: História Pública, Pós-Verdade, Negacionismo, Consumo.
Relação do índice de gastos com pessoal e a crise fiscal do estado do Rio de Janeiroum estudo comparativo interestadual
Authors: Gerônimo-Santos Rogelio , Carvalho Renato Rugene de , Nascimento Sidnei Pereira do 
Published: January 2020

Este estudo tem como objetivo avaliar o índice de gastos com pessoal dos estados e do Distrito Federal no período de 2000 a 2015 a partir do Estado do Rio de Janeiro, após o início da crise subprime, em 2008. A metodologia empregada foi o modelo econométrico de Diferença em Diferença com Ajuste de Poligonais. Os resultados demonstraram que todos estados aumentaram seus índices de gastos com pessoal após o ano de 2008. Todavia, o índice do Estado do Rio de Janeiro superou, comparativamente, aos demais estados da Confederação, após o início da crise subprime, em 2008. ABSTRACT The objective of this study is to evaluate the personnel expenditure of the states and the Federal District between 2000 to 2015 from the State of Rio de Janeiro after the start of the subprime crisis in 2008. The methodology used was the econometric model of Difference in Difference with Polygonal Adjustment. The results showed that all states increased their personnel expenses after 2008. However, the Rio de Janeiro state index surpassed compared to the other states of the Confederation e o Federal District, after the start of the subprime crisis in 2008. Keywords: Subprime Crisis; State Finances; Index of Personnel Expenses; Rio de Janeiro;
Nursing Care for Patients Submitted to Coronary Transluminal Angioplasty: An Integrative Review
Authors: Costa Gabriel Fazzi , Sardinha Daniele Melo , Oliveira Virgínia Mercês Lara Pessoa , Barata Faena Santos , Silva Paulo Henrique Viana da , Mafra Ingrid Naiana Pinto , Oliveira Larysse Caldas de , Lima Tatiana Fabíola da Silva , Nunes Maria Catarina Anselmo 
Published: January 2020

Aims: To verify the scientific evidence in the literature about nursing care after coronary transluminal angioplasty, from 2005 to 2019.
Methodology: This is an Integrative Review, performed in the LILACS, MEDLINE and Google Scholar databases, including original and review articles, theses, dissertations and monographs published in Portuguese or English in the last 15 years (2005-2019). Data were collected using the Ursi’s instrument and data analysis was carried out by the use Bardin’s Content Analysis.
Results: 06 articles were found and two categories emerged: Nursing diagnoses after coronary transluminal angioplasty and Nursing interventions after coronary transluminal angioplasty. The nursing process should be carried out in its entirety so that the results of nursing care are effective and the improvement of the quality of the services provided is continuous.
Conclusion: it is concluded that nursing actions are beyond bedside care, as they also include management services of inputs and human resources.