bluuebunny/crossref_metadata_2025_split huggingface dataset:
“All Parties Treat Silesians Instrumentally”: On Political Representation at the Regional Level
Authors: Turska-Kawa Agnieszka , Glajcar Rafał 
Published: October 2020

AbstractThe turn of the 20th century experienced an intensification of processes that strengthened Silesian identity, which became an important element of political debate in the region. This was reflected in the emergence of a growing number of entities that placed Silesian issues among their priority objectives and defined themselves as representatives of the interests of Silesia and Silesians. The aim of the study was to verify the political representative potential of groups in Upper Silesia. We accepted the hypothesis that the stronger the identity of a particular group (regional or national) the greater the probability that entities placing fundamental objectives strictly within the scope of regional issues should enjoy broad support in the region, and such entities consequently should be perceived as political representatives of the group. A study conducted using the categorized interview method (N=54) proves quite clearly that Silesians are unable to identify entities on the regional political scene that could represent them sufficiently. The determinants of this state of affairs are found not only in the negative actions of political entities but also in the absence of a clear vision of representation, which could constitute a basis for the formulated expectations of Silesians.
Personnes âgées à domicile avec limitations fonctionnelles : étude préliminaire d’une intervention centrée sur le bien-être et l’autonomie
Authors: Meynet Stéphanie , Beaudoin Marine , Smeding Annique 
Published: October 2020

ABSTRACTIn the context of demographic aging, preventing autonomy loss is a major issue. Adapting care systems to help keep seniors at home is a daily challenge. “La Mutualité Française”, a national mutual insurance company, has implemented in one of its healthcare services an innovative program to strengthen well-being: “The Well-Being Autonomy Pole.” This program comprises five Prevention and Support Care components and hypothesizes that strengthening the well-being of elderly people already suffering from physical limitations would prevent their autonomy decline. The originality of this program is its focus on elderly people who have rarely been studied in terms of preventing autonomy loss, given their existing functional limitations. A first evaluation was carried out over three months to verify the methodological feasibility of an impact assessment and to provide preliminary results on the effectiveness of the program. Key findings suggest improved levels of self-esteem, physical well-being, psychological autonomy and decreased anxiety. Methodological limitations of this first feasibility assessment and perspectives for future research are discussed.
Safety and effect of sildenafil on treating paediatric pulmonary arterial hypertension: a meta-analysis on the randomised controlled trials
Authors: Zhang Qingyou , Xu Bowen , Lv Jichen , Wang Zhijian , Du Junbao 
Published: October 2020

AbstractBackground:Efficacy of sildenafil in treating paediatric pulmonary arterial hypertension is controversial. This systematic review aimed to explore the safety and effect of sildenafil on treating paediatric pulmonary arterial hypertension (PAH) through meta-analysis.Methods and results:In this study, the electronic databases, including the Cochran Library database, EMBASE, and MEDLINE were systemically retrieved to identify the related randomised controlled trials (RCTs). Two reviewers had independently completed study selection, data collection, and assessment of the bias risk. Amongst 938 articles researched according to our retrieval strategy, 15 papers that involved 673 cases had been screened. Relative to control group, the sildenafil group had markedly reduced mortality (RR = 0.25, 95% CI: 0.12–0.51; p < 0.0001), but difference within the mortality was not statistically significant between high- and low-dose sildenafil groups (p = 0.152). Nonetheless, difference of the mean pulmonary arterial pressure between sildenafil as well as control group was of no statistical significance. Differences in the length of hospital stay and the incidences of pulmonary hypertensive crisis between children with PAH and controls were of no statistical significance. However, the summary estimate favoured that sildenafil reduced the duration of mechanical ventilation time, as well as the length of ICU stay and inotropic support.Conclusions:Sildenafil therapy reduces the mortality of PAH patients, but its effects on the haemodynamic outcomes and other clinical outcomes are still unclear.
Safety and effectiveness of lurasidone in adolescents with schizophrenia: results of a 2-year, open-label extension study
Authors: Correll Christoph U. , Findling Robert L. , Tocco Michael , Pikalov Andrei , Deng Ling , Goldman Robert 
Published: October 2020

AbstractBackgroundMinimal long-term benefit: Risk data are available regarding antipsychotic treatments for schizophrenia in pediatric populations. This study evaluated the long-term safety, tolerability, and effectiveness of lurasidone in adolescents with schizophrenia.MethodsPatients aged from 13 to 17 who completed 6 weeks of double-blind (DB), placebo-controlled treatment with lurasidone were enrolled in a 2-year, open-label (OL), flexible dose (20-80 mg/day) lurasidone treatment study. Safety was assessed via spontaneous reporting, rating scales, body weight measurement, metabolic, and prolactin testing. Effectiveness measures included the Positive and Negative Syndrome Scale (PANSS) total score.ResultsAbout 271 patients completed 6 weeks of DB treatment and entered the 2-year OL extension study. Altogether, 42.4% discontinued prematurely, 10.7% due to adverse events. During OL treatment, the most common adverse events were headache (24.0%); anxiety (12.9%), schizophrenia, and nausea (12.5%); sedation/somnolence (12.2%); and nasopharyngitis (8.9%). Minimal changes were observed on metabolic parameters and prolactin. Mean change from DB baseline in weight at week 52 and week 104 was +3.3 kg and + 4.9 kg, respectively, compared to an expected weight gain of +3.4 kg and + 5.7 kg, respectively, based on the sex- and age-matched US Center for Disease Control normative data. Continued improvement was observed in PANSS total score, with mean change from OL baseline of −15.6 at week 52 and −18.4 at week 104.ConclusionIn adolescents with schizophrenia, long-term lurasidone treatment was associated with minimal effects on body weight, lipids, glycemic indices, and prolactin. Continued improvement in symptoms of schizophrenia was observed over 2 years of lurasidone treatment.
A compact band-notched antenna with high isolation for UWB MIMO applications
Authors: Masoodi Issmat Shah , Ishteyaq Insha , Muzaffar Khalid , Magray M. Idrees 
Published: October 2020

AbstractA compact antenna module with a single band notch at wireless local area network (WLAN) (5.725–5.825 GHz) for ultra-wideband (UWB) multiple input multiple output (MIMO) applications is proposed. Proposed antenna which acquires size of 0.299 λ × 0.413 λ × 0.005 λ mm3 at 3.1 GHz consists of two symmetrical radiators placed side by side on global merchandise link (GML) 1000 substrate (εr = 3.2, tan δ = 0.004). Isolation between the antenna elements is >18 dB in the whole UWB band, which is achieved by introducing the vertical stub and H-slot between the monopole radiators in the ground plane. The simulated and measured results of the antenna system are in good agreement. The proposed antenna covers entire UWB with impedance bandwidth (|S11| < −15 dB) from 3.1 to 11 GHz except at WLAN notched band. The designed antenna module bears low envelope correlation coefficient and minimal multiplexing efficiency hence fulfilling criteria suitable for various wireless MIMO applications.
OMPS LP Observations of PSC Variability During the NH 2019–2020 Season
Authors: DeLand Matthew T. , Bhartia Pawan K. , Kramarova Natalya , Chen Zhong 
Published: October 2020

AbstractSeasonal ozone depletion in the polar regions (during late winter and early spring) depends on the presence and distribution of polar stratospheric clouds (PSCs). In this paper, we present new satellite observations of PSCs by the Ozone Mapping and Profiler Suite (OMPS) Limb Profiler (LP) instrument. LP cloud detections are identified as PSCs based on location, altitude, and background atmosphere temperature. The hyperspectral capabilities of OMPS LP enable PSC detection to occur concurrent with stratospheric ozone measurements from the same instrument. We present PSC results from the Northern Hemisphere 2019–2010 winter/spring season to illustrate the exceptional nature of this season. Future OMPS LP instruments flying on Joint Polar Satellite System (JPSS) satellites will continue PSC observations into the 2030s.
Prima Facie Evidence of the Fast Impact of a Lightning Stroke on the Lower Ionosphere
Authors: Qin Zilong , Chen Mingli , Lyu Fanchao , Cummer Steven A. , Gao Yan , Liu Feifan , Zhu Baoyou , Du Ya‐ping , Usmani Asif , Qiu Zongxu 
Published: October 2020

AbstractStudies show that intense lightning discharges can perturb nighttime lower ionosphere through induced electromagnetic fields. We report here new evidence that every lightning stroke, regardless of intensity, has an impact on both daytime and nighttime lower ionosphere. Through analysis of thousands of negative cloud‐to‐ground lightning strokes in southern China, we find that skywave features of a lightning sferic are closely related to its source intensity. Variations with increasing lightning intensity show a higher reflectivity from nighttime ionosphere but a larger time delay from daytime ionosphere. It also shows that the ionosphere recovers from the lightning impact in a time shorter than tens of milliseconds. This suggests that there exists a direct and fast nonlinear coupling between lightning‐generated electromagnetic fields and lower ionosphere, making the ionospheric response to a lightning stroke dependent of the lightning intensity. A candidate mechanism for this is the Joule heating effect, but it needs future studies.
A Double Hemispherical Probe for Characterizing and Minimizing the Self‐Wake Effects on Probe Measurements
Authors: Samaniego Joseph I. , Yeo Li Hsia , Wang Xu 
Published: October 2020

AbstractSpace‐borne Langmuir probes generally have a self‐wake behind themselves due to supersonic relative velocities (Mach number M > 1) between the spacecraft and ambient plasma ions. Such a wake may create difficulties for correctly measuring plasma characteristics. Here we present a new technique—the Double Hemispherical Probe (DHP) to characterize and minimize the self‐wake effects on probe measurements. The DHP consists of two hemispheres that are simultaneously swept with a bias voltage to obtain two independent current‐voltage (I‐V) curves, which are used to identify the wake effects of the probe. A laboratory DHP model is inserted in plasma flows (M > 10) created in the Colorado Solar Wind Experiment (CSWE) chamber. In this case, the ion current is the ram current collected by the upstream hemisphere of the DHP, leaving an ion wake behind the downstream hemisphere. A wide range of the Debye ratio RD (ratio of the probe radius to electron Debye length) is tested, and it is found that (1) when RD < 1, the electron currents collected by the two hemispheres are similar, indicating a uniform electron density around the probe, and (2) when RD > 1, the electron current collected by the downstream hemisphere becomes lower than the upstream, indicating a reduced electron density in the probe's wake due to the ambipolar electric field effect. In this case, the electron density measured by traditional single Langmuir probes will be underestimated. With the DHP, we can use the upstream hemisphere measurements to minimize the self‐wake effects.
An Assessment of the Temporal Variability in the Annual Cycle of Daily Antarctic Sea Ice in the NCAR Community Earth System Model, Version 2: A Comparison of the Historical Runs With Observations
Authors: Raphael Marilyn N. , Handcock Mark S. , Holland Marika M. , Landrum Laura L. 
Published: October 2020

AbstractUnderstanding the variability of Antarctic sea ice is an ongoing challenge given the limitations of observed data. Coupled climate model simulations present the opportunity to examine this variability in Antarctic sea ice. Here, the daily sea ice extent simulated by the newly released National Center for Atmospheric Research (NCAR) Community Eart h System Model Version 2 (CESM2) for the historical period (1979–2014) is compared to the satellite‐observed daily sea ice extent for the same period. The comparisons are made using a newly developed suite of statistical metrics that estimates the variability of the sea ice extent on timescales ranging from the long‐term decadal to the short term, intraday scales. Assessed are the annual cycle, trend, day‐to‐day change, and the volatility, a new statistic that estimates the variability at the daily scale. Results show that the trend in observed daily sea ice is dominated by subdecadal variability with a weak positive linear trend superimposed. The CESM2 simulates comparable subdecadal variability but with a strong negative linear trend superimposed. The CESM2's annual cycle is similar in amplitude to the observed, key differences being the timing of ice advance and retreat. The sea ice begins its advance later, reaches its maximum later and begins retreat later in the CESM2. This is confirmed by the day‐to‐day change. Apparent in all of the sea ice regions, this behavior suggests the influence of the semiannual oscillation of the circumpolar trough. The volatility, which is associated with smaller scale dynamics such as storms, is smaller in the CESM2 than observed.
Stable Oxygen Isotope Composition Is Biased by Shell Calcification Intensity in Planktonic Foraminifera
Authors: Weinkauf M. F. G. , Groeneveld J. , Waniek J. J. , Vennemann T. , Martini R. 
Published: October 2020

AbstractPlanktonic Foraminifera are widely used for environmental reconstructions through measurements of their shell's geochemical characteristics, including its stable oxygen and carbon isotope composition. Using these parameters as unbiased proxies requires a firm knowledge of all potential confounding factors influencing foraminiferal shell geochemistry. One such parameter is the shell calcification intensity (shell weight normalized for shell size) that may influence the shell δ18O value either bioenergetically (by reducing energy available and required for equilibrium isotope fractionation during faster calcification) or kinetically (by influencing calcification depth through the shell's density contrast with seawater). Specimens from the Globigerinoides ruber/elongatus complex from a sediment trap in the North Atlantic have been used to quantify the influence of shell calcification intensity on shell δ18O values. Shell calcification intensity was found to have a significant effect on the shell stable oxygen isotope composition in all species. Through model fitting, it is suggested that the effect size may be in a range of 1‰ to 2‰ (depending on species, depth migration, and local oceanographic conditions). We show that the confounding effect of shell calcification intensity on stable oxygen isotope composition can be of importance, depending on the anticipated precision of the derived reconstructions. A framework is provided to quantify this effect in future studies.
Local Storage Dynamics of Individual Wetlands Predict Wetlandscape Discharge
Authors: Klammler Harald , Quintero Carlos J. , Jawitz James W. , McLaughlin Daniel L. , Cohen Matthew J. 
Published: October 2020

AbstractWetlands provide valuable hydrological, ecological, and biogeochemical functions, both alone and in combination with other elements comprising the wetlandscape. Understanding the processes and mechanisms that drive wetlandscape functions, as well as their sensitivity to natural and man‐made alterations, requires a sound physical understanding of wetland hydrodynamics. Here, we develop and apply a single reservoir hydrologic model to a low‐relief karst wetlandscape in southwest Florida (≈103 km2 of Big Cypress National Preserve) using precipitation P and potential evapotranspiration PET as climatic drivers. This simple approach captures the dynamics of storage for individual wetlands across the entire wetlandscape and accurately predicts landscape discharge. Key model insights are the importance of depth‐dependent extinction of evapotranspiration ET and the negligible effects of depth‐dependent specific yield, the effects of which are diluted by landscape relief. We identify three phases of the wetlandscape hydrological regime: dry, wet‐stagnant, and wet‐flowing. The model allowed a simple steady‐state analysis, which demonstrated the sudden seasonal shift between wet‐stagnant and wet‐flowing states, indicating a consistent threshold at P ≈ PET. Notably, stage data from any single wetland appears sufficient for accurate whole‐landscape discharge prediction because of the relative homogeneity in timing and duration of local wetland hydrologic connectivity in this landscape. We also show that this method will be transferable to other wetlandscapes, where individual storage elements respond hydrologically synchronously, whereas model performance is expected to deteriorate for hydrologically more heterogeneous wetlandscapes.
Rainforest-to-pasture conversion stimulates soil methanogenesis across the Brazilian Amazon
Authors: Kroeger Marie E , Meredith Laura K , Meyer Kyle M , Webster Kevin D , de Camargo Plinio Barbosa , de Souza Leandro Fonseca , Tsai Siu Mui , van Haren Joost , Saleska Scott , Bohannan Brendan J M , Rodrigues Jorge L Mazza , Berenguer Erika , Barlow Jos , Nüsslein Klaus 
Published: October 2020

AbstractThe Amazon rainforest is a biodiversity hotspot and large terrestrial carbon sink threatened by agricultural conversion. Rainforest-to-pasture conversion stimulates the release of methane, a potent greenhouse gas. The biotic methane cycle is driven by microorganisms; therefore, this study focused on active methane-cycling microorganisms and their functions across land-use types. We collected intact soil cores from three land use types (primary rainforest, pasture, and secondary rainforest) of two geographically distinct areas of the Brazilian Amazon (Santarém, Pará and Ariquemes, Rondônia) and performed DNA stable-isotope probing coupled with metagenomics to identify the active methanotrophs and methanogens. At both locations, we observed a significant change in the composition of the isotope-labeled methane-cycling microbial community across land use types, specifically an increase in the abundance and diversity of active methanogens in pastures. We conclude that a significant increase in the abundance and activity of methanogens in pasture soils could drive increased soil methane emissions. Furthermore, we found that secondary rainforests had decreased methanogenic activity similar to primary rainforests, and thus a potential to recover as methane sinks, making it conceivable for forest restoration to offset greenhouse gas emissions in the tropics. These findings are critical for informing land management practices and global tropical rainforest conservation.
Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping
Authors: Lawson Christopher E , Nuijten Guylaine H L , de Graaf Rob M , Jacobson Tyler B , Pabst Martin , Stevenson David M , Jetten Mike S M , Noguera Daniel R , McMahon Katherine D , Amador-Noguez Daniel , Lücker Sebastian 
Published: October 2020

Abstract
Anaerobic ammonium-oxidizing (anammox) bacteria mediate a key step in the biogeochemical nitrogen cycle and have been applied worldwide for the energy-efficient removal of nitrogen from wastewater. However, outside their core energy metabolism, little is known about the metabolic networks driving anammox bacterial anabolism and use of different carbon and energy substrates beyond genome-based predictions. Here, we experimentally resolved the central carbon metabolism of the anammox bacterium Candidatus ‘Kuenenia stuttgartiensis’ using time-series 13C and 2H isotope tracing, metabolomics, and isotopically nonstationary metabolic flux analysis. Our findings confirm predicted metabolic pathways used for CO2 fixation, central metabolism, and amino acid biosynthesis in K. stuttgartiensis, and reveal several instances where genomic predictions are not supported by in vivo metabolic fluxes. This includes the use of the oxidative branch of an incomplete tricarboxylic acid cycle for alpha-ketoglutarate biosynthesis, despite the genome not having an annotated citrate synthase. We also demonstrate that K. stuttgartiensis is able to directly assimilate extracellular formate via the Wood–Ljungdahl pathway instead of oxidizing it completely to CO2 followed by reassimilation. In contrast, our data suggest that K. stuttgartiensis is not capable of using acetate as a carbon or energy source in situ and that acetate oxidation occurred via the metabolic activity of a low-abundance microorganism in the bioreactor’s side population. Together, these findings provide a foundation for understanding the carbon metabolism of anammox bacteria at a systems-level and will inform future studies aimed at elucidating factors governing their function and niche differentiation in natural and engineered ecosystems.
Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells
Authors: Kwon Yoonjung , Bang Yeojin , Moon Soung-Hee , Kim Aeri , Choi Hyun Jin 
Published: October 2020

AbstractAmitriptyline is a tricyclic antidepressant commonly prescribed for major depressive disorders, as well as depressive symptoms associated with various neurological disorders. A possible correlation between the use of tricyclic antidepressants and the occurrence of Parkinson’s disease has been reported, but its underlying mechanism remains unknown. The accumulation of misfolded protein aggregates has been suggested to cause cellular toxicity and has been implicated in the common pathogenesis of neurodegenerative diseases. Here, we examined the effect of amitriptyline on protein clearance and its relevant mechanisms in neuronal cells. Amitriptyline exacerbated the accumulation of abnormal aggregates in both in vitro neuronal cells and in vivo mice brain by interfering with the (1) formation of aggresome-like aggregates and (2) autophagy-mediated clearance of aggregates. Amitriptyline upregulated LC3B-II, but LC3B-II levels did not increase further in the presence of NH4Cl, which suggests that amitriptyline inhibited autophagic flux rather than autophagy induction. Amitriptyline interfered with the fusion of autophagosome and lysosome through the activation of PI3K/Akt/mTOR pathway and Beclin 1 acetylation, and regulated lysosome positioning by increasing the interaction between proteins Arl8, SKIP, and kinesin. To the best of our knowledge, we are the first to demonstrate that amitriptyline interferes with autophagic flux by regulating the autophagosome maturation during autophagy in neuronal cells. The present study could provide neurobiological clue for the possible correlation between the amitriptyline use and the risk of developing neurodegenerative diseases.