bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception
Authors: Ayumi Rasyidah Ryta , Shaik Mossadeq Wan Mastura , Zakaria Zainul Amiruddin , Bakhtiar Muhammad Taher , Kamarudin Nadhirah , Hisamuddin Nadia , Talib Madihah , Sabar Aina Mardhiah 
Published: April 2020

AbstractThe antinociceptive property of Centella asiatica extracts is known but the analgesic activity of its bioactive constituent asiaticoside has not been reported. We evaluated the antinociceptive activity of orally (p. o.) administered asiaticoside (1, 3, 5, and 10 mg/kg) in mice using the 0.6% acetic acid-induced writhing test, the 2.5% formalin-induced paw licking test, and the hot plate test. The capsaicin- and glutamate-induced paw licking tests were employed to evaluate the involvement of the vanilloid and glutamatergic systems, respectively. Asiaticoside (3, 5, and 10 mg/kg, p. o.) reduced the rate of writhing (p < 0.0001) by 25.3, 47.8, and 53.9%, respectively, and increased the latency period (p < 0.05) on the hot plate at 60 min post-treatment until the end of the experiment. Moreover, asiaticoside (3, 5, and 10 mg/kg, p. o.) shortened the time spent in licking/biting the injected paw (p < 0.0001) in the early phase of the formalin test by 45.7, 51.4, and 52.7%, respectively, and in the late phase (p < 0.01) by 23.6, 40.5, and 50.6%, respectively. Antinociception induced by asiaticoside (10 mg/kg) was not antagonized by naloxone in both the 2.5% formalin-induced nociception and the hot plate test, indicating a nonparticipation of the opioidergic system. Asiaticoside (1, 3, 5, and 10 mg/kg, p. o.) reduced the duration of biting/licking the capsaicin-injected paw (p < 0.0001) by 40.5, 48.2, 59.5, and 63.5%, respectively. Moreover, asiaticoside (5 and 10 mg/kg) shortened the time spent in biting/licking the glutamate-injected paw (p < 0.01) by 29.9 and 48.6%, respectively. Therefore, asiaticoside (5 and 10 mg/kg, p. o.) induces antinociception possibly through the vanilloid and glutamatergic systems.
Network Pharmacological Screening of the Active Ingredients and Hypoglycemic Effect of Isodon rubescens in the Treatment of Diabetes
Authors: Jintao Xue , Shasha Yu , Jincai Wang , Chunyan Li , Mengya Yang , Yongli Shi 
Published: April 2020

AbstractThis study was firstly to study the relationship of “ingredient-target-pathway” and the pharmacological effects of Isodon rubescens for the treatment of diabetes. Based on a network pharmacology method, 138 active ingredients of Isodon rubescens were screened from the relative literatures, and their targets were confirmed by comparing these with the hypoglycemic targets in the DrugBank database. Results showed that Isodon rubescens contained 25 hypoglycemic ingredients, such as rabdoternin A, rabdoternin B, and epinodosinol. These ingredients could activate 6 hypoglycemic targets, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), integrin α-L (ITGAL), integrin β-2 (ITGB2), progesterone receptor (PGR), glucocorticoid receptor (NR3C1), and nuclear receptor subfamily 1 group I member 2 (NR1I2). These targets were involved in 94 signaling pathways, such as the Rap1, PI3K-Akt, and HIF-1 signaling pathways. The cell viability showed that the human umbilical vein endothelial cells (HUVECs) treated with alcohol extract (1.00 g/L) and the water extract (0.13 – 0.50 g/L) exhibited high viability compared to the model group (p < 0.05), respectively. 0In animal experiments, the rats treated with water extract of Isodon rubescens showed significant hypoglycemic effects compared to rats in the model group (p < 0.05). Overall, this approach provides an efficient strategy to explore hypoglycemic ingredients of Isodon rubescens and other traditional Chinese medicine.
Design, Construction, and Early Results of a Formal Local Revision Knee Arthroplasty Registry
Authors: Visvanathan Aravinthan , Wilson Christopher , Jackman Emma , Wong Geraldine , Krishnan Jegan 
Published: April 2020

AbstractNational registries for primary and revision knee arthroplasty in Australia, New Zealand, and Europe have been successful in ensuring quality control and providing information to drive crucial research. However, they face challenges in delivering the granularity of data useful at a local hospital level. Our aim was to address these challenges by designing and initiating a local revision knee arthroplasty registry and combining the data with national figures to better evaluate the types of revisions undertaken, and improve patient outcomes and care. All revision knee arthroplasty cases in our center were analyzed from April 2014 to December 2015 using our standardized diagnostic algorithm. Information such as reason and type of revision was collected. Results were compared with Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) data. Primary outcome was comparison against our center's historical data between January 1999 and December 2013 and secondary outcome was comparison against national data prior to and after our intervention. Between April 2014 and December 2015, our center performed 35 revision knee arthroplasties. When compared with our center's historical data, we observed lower rates of revision knee arthroplasties due to “pain” (14.2 vs. 36.7%) with corresponding lower rates of patella button only revision (8.6 vs. 39.2%). Compared with national data before our intervention, we had lower revision rates from infection (14.2 vs. 22.3%) and loosening/lysis (11.4 vs. 29.2%). We undertook more minor revisions (45.7 vs. 30.5%) and similar total revisions (25.7 vs. 25.3%). Similar trends were seen in comparison to national data after our intervention. Our study shows that a local registry can be designed and successfully implemented for revision knee arthroplasty surgery. Data can be easily compared with historic and current hospital and national registry data trends to assess quality and robustness of revision arthroplasty programs. Our early results suggest our center has succeeded in reducing incidences of major revisions, complications, and the risk of re-revision surgery. This will improve the quality of our service with a significant cost reduction for our local health care budget.
Preventing Diagnostic Errors in Ambulatory Care: An Electronic Notification Tool for Incomplete Radiology Tests
Authors: Weingart Saul N. , Yaghi Omar , Barnhart Liz , Kher Sucharita , Mazzullo John , Roberts Kari , Lominac Eric , Gittelson Nancy , Argyris Philip , Harvey William 
Published: April 2020

Abstract
Background Failure to complete recommended diagnostic tests may increase the risk of diagnostic errors.
Objectives The aim of this study is to develop and evaluate an electronic monitoring tool that notifies the responsible clinician of incomplete imaging tests for their ambulatory patients.
Methods A results notification workflow engine was created at an academic medical center. It identified future appointments for imaging studies and notified the ordering physician of incomplete tests by secure email. To assess the impact of the intervention, the project team surveyed participating physicians and measured test completion rates within 90 days of the scheduled appointment. Analyses compared test completion rates among patients of intervention and usual care clinicians at baseline and follow-up. A multivariate logistic regression model was used to control for secular trends and differences between cohorts.
Results A total of 725 patients of 16 intervention physicians had 1,016 delayed imaging studies; 2,023 patients of 42 usual care clinicians had 2,697 delayed studies. In the first month, physicians indicated in 23/30 cases that they were unaware of the missed test prior to notification. The 90-day test completion rate was lower in the usual care than intervention group in the 6-month baseline period (18.8 vs. 22.1%, p = 0.119). During the 12-month follow-up period, there was a significant improvement favoring the intervention group (20.9 vs. 25.5%, p = 0.027). The change was driven by improved completion rates among patients referred for mammography (21.0 vs. 30.1%, p = 0.003). Multivariate analyses showed no significant impact of the intervention.
Conclusion There was a temporal association between email alerts to physicians about missed imaging tests and improved test completion at 90 days, although baseline differences in intervention and usual care groups limited the ability to draw definitive conclusions. Research is needed to understand the potential benefits and limitations of missed test notifications to reduce the risk of delayed diagnoses, particularly in vulnerable patient populations.
Antibiotic Prophylaxis Trials in Obstetrics: A Call for Pediatric Collaboration
Authors: McLaren Rodney A. , Atallah Fouad , Minkoff Howard 
Published: April 2020

AbstractSurgical site infections are common complications of cesarean delivery. Many recent studies, including meta-analyses, have assessed the efficacy of antibiotic prophylaxis. Those articles have demonstrated that preincision antibiotic prophylaxis reduces the incidence of surgical site infections postcesarean, and that the use of adjunctive azithromycin further reduces infection after nonelective cesarean deliveries. However, long-term effects of fetal exposure to antibiotic prophylaxis—including asthma, obesity, and alterations in microbiota—have also been demonstrated. We suggest that while studies of optimal antibiotic regimens proceed, considerations of the potential risks to the neonate should be factored into discussions of benefits and burdens.
Comparison of Rocuronium and Vecuronium in Patients Undergoing Elective Ultrafast-Track Off-Pump Coronary Artery Bypass Surgery
Authors: Shah Kalpana S. , Kulshrestha Aayush 
Published: April 2020

Abstract
Background Neuromuscular blocking drugs are necessary in cardiac surgery to facilitate smooth intubation and ventilation conditions, avoid patient movement, reduce oxygen consumption, and prevent shivering. Hemodynamic stability is very essential in cardiac surgery because the coronary reserve is below normal in such patients.
Aims This study was conducted with the objective of comparing rocuronium, the “near-ideal” muscle relaxant with vecuronium, an already established neuromuscular blocking agent in patients undergoing elective ultrafast-track off-pump coronary artery bypass surgery (CABG).
Settings and Design This prospective, randomized comparative study included 60 patients scheduled for elective off-pump CABG procedures under general anesthesia in the period between May 2015 and March 2016.
Materials and Methods Patients were randomized in equal numbers to either the rocuronium group or the vecuronium group, and intubating conditions and various hemodynamic parameters were observed at different time points.
Statistical Analysis Used Categorical variables were evaluated using the chi-square test, whereas the Student t-test or Mann–Whitney test were used for continuous variables.
Results Pulse rate in the rocuronium group was lesser (79.97 ± 7.42) (p < 0.05) at the time of intubation as compared with the vecuronium group (92.33 ± 8.93). Systolic blood pressure was higher in the vecuronium group (150.70 ± 14.05) at the time of intubation as compared with the rocuronium group (130.27 ± 9.95) (p < 0.05). Intubating conditions, mean arterial pressure, and diastolic blood pressure changes were similar in both groups.
Conclusions Rocuronium provides good-to-excellent intubating conditions and is devoid of any significant cardiovascular changes causing hemodynamic instability when compared with vecuronium in patients undergoing elective ultrafast-track off-pump CABG.
The Common European Framework of Reference (CEFR) in French immersion teacher education
Authors: Arnott Stephanie , Vignola Marie-Josée 
Published: April 2020

Abstract
Over 11% of Canadian students are currently enrolled in French immersion (FI) – a program where French is a subject of study and is
the language of instruction in at least two content areas. Research shows that stakeholders in FI initial teacher education (ITE)
programs identify French language proficiency development as an area of high priority; however, Canadian ITE programs do not
typically provide linguistic support. This chapter reports on an adaptation and implementation of the Common European
Framework of Reference (CEFR) (specifically, the European Language Portfolio [ELP]) as part of a
remedial 24-week French writing course in an FSL ITE program focused on developing French proficiency. Student-teachers
(n = 25) and the course instructor identified strengths and challenges associated with this initiative via
surveys and interviews. Findings show participant convergence and divergence on the portfolio experience, raising implications for
decision-making related to its use in ITE programs targeting FI teachers.
Becoming a “language-aware” content teacher
Authors: He Peichang , Lin Angel M.Y. 
Published: April 2020

Abstract
Building on and extending the frameworks of Teacher Language Awareness (TLA) in
second/foreign language education and content-based/CLIL education (Andrews, 2007; Andrews & Lin, 2017; Lindahl & Watkins, 2015), this chapter argues that
effective teaching of academic content in an L2 requires a special kind of
teacher knowledge that goes beyond simple addition of content knowledge and
Knowledge About Language (KAL). Through an ethnographic case study, the
researchers investigated the development of a science teacher’s TLA and teacher
identity through her participation in a school-university collaborative project.
Based on analysis of data from classroom observations, interviews, and lesson
video stimulated commentaries, the researchers have developed a model focusing
on CLIL teacher professional development as a collaborative, dynamic and
dialogic process, where both teachers and teacher educators (TEs) are
co-developing their knowledge and expertise in CLIL.
Teacher adaptations to support students with special education needs in French immersion
Authors: Mady Callie 
Published: April 2020

Abstract
As of late, French immersion (FI) teachers have been encouraged to adapt their instruction to support the inclusion and success of
students with learning difficulties. In particular, pedagogical concepts such as Universal Design for Learning (UDL) (National
Center on Universal Design for Learning, 2014) and differentiated instruction (Tomlinson,
2004) have been promoted as means to do so. This study used observations of nine FI teachers’ classes with the view to
exploring their adaptations for students with learning difficulties in hopes of identifying future professional development
directions. The observations revealed that the FI teachers were aptly adapting their instruction for the class as a whole whereas
they were less apt to modify for individual students. In order to further their inclusive practices, the FI teachers in this study
would benefit from future professional development opportunities that focus on differentiating instruction for individuals and
conversations about if and how teacher language choices can provide additional means of differentiation.
Bulleyaconitine A inhibits the lung inflammation and airway remodeling through restoring Th1/Th2 balance in asthmatic model mice
Authors: Liu Liping , Wang Shuyun , Xing Haiyan , Sun Yuemei , Ding Juan , He Ning 
Published: April 2020

AbstractThe current study aimed to study the effects of Bulleyaconitine A (BLA) on asthma. Asthmatic mice model was established by ovalbumin (OVA) stimulation, and the model mice were treated by BLA. After BLA treatment, the changes in lung and airway resistances, total and differential leukocytes in the bronchoalveolar lavage fluid (BALF) were detected, and the changes in lung inflammation and airway remodeling were observed. Moreover, the secretion of IgE, Th1/Th2-type and IL-17A cytokines in BALF and serum of the asthmatic mice were determined. The resuts showed that BLA attenuated OVA-induced lung and airway resistances, inhibited the inflammatory cell recruitment in BALF and the inflammation and airway remodeling of the asthmatic mice. In addition, BLA suppressed the secretion of IgE, Th2-type cytokines, and IL-17A, but enhanced secretions of Th1-type cytokines in BALF and serum. The current study discovered that BLA inhibited the lung inflammation and airway remodeling via restoring the Th1/Th2 balance in asthmatic mice.
Phytic acid exerts protective effects in cerebral ischemia-reperfusion injury by activating the anti-oxidative protein sestrin2
Authors: Liu Jing , Li Ying , Mei Chunli , Ning Xianbin , Pang Jinfeng , Gu Lei , Wu Liang 
Published: April 2020

Abstract
Cerebral ischemia reperfusion (I/R) is a therapeutic strategy for ischemia; however, it usually causes injury by the aspect of inflammation and neuron apoptosis. This investigation aims to investigate the protective effects of phytic acid (IP6) for cerebral I/R injury in vitro. PC-12 cells under Oxygen and glucose deprivation/reperfusion (OGD/R) were performed to mimic cerebral I/R. IP6 was pretreated before PC-12 cells under OGD/R treatment. The data showed that IP6 activated the expression of sestrin2 in OGD/R injured PC-12 cells. IP6 inhibited OGD/R induced inflammation, oxidative stress, and apoptosis by activating sestrin2. Besides, p38 MAPK may mediate the effects of sestrin2 activated by IP6. Therefore, IP6 can be a potential drug to prevent neurological damage in cerebral I/R injury.
Google forms utilization for student satisfaction survey towards quality of service at Universitas Muhammadiyah Tasikmalaya
Authors: Nurmahmudah Endah , Nuryuniarti Rissa 
Published: April 2020

Abstract
Research on the survey of student satisfaction with service quality at Universitas Muhammadiyah Tasikmalaya (UMTAS) was conducted in July 2019. This study aims to determine the level of student satisfaction with the quality of services at UMTAS. With multiple linear regression methods and using total sampling technique, the entire population is the object of research. The population in this study were all semester 4 UMTAS students. In this case the distribution and filling out the questionnaire as a data collection tool using Google Forms. The researcher only informs the address of the shortlink that has been made, namely bit.ly/2WZtLr7 to the respondent, and the respondent can access the link from their respective Android phones. The results of this study indicate that the level of student satisfaction with 5 variables has a simultaneous and partial influence of 86.6%. Based on the partial t count, the most influential is the tangible variable but all indicators have the same effect on student satisfaction significantly. While the rest (13.2%) is influenced by other variables not examined in this study.
Sample Identification Approach by K-Means Clustering In Thinner Retail Market Segmentation
Authors: Listiyoko Langgeng , Purno Marhaendro 
Published: April 2020

Abstract
Ingredients identification of thinner sample in retail market is very easy to do by a special machine, and then the product would be copied. Then the problem is how to set the sample of competitor product into the segmentation based on many consideration aspects. Data mining helps user to identify whether the sample is a member of one segmentation or not based on the closest characteristic value that observed. K-means clustering calculate a numeric value of each sample product’s characteristic then classify into a number desired cluster. Data history has 21 existing products and classified into 4 cluster at the beginning, then two data tests (competitor products) put into the data set to identify what is the nearest cluster. The result of K-means clustering shows the first competitor as cluster_1 while the second one is cluster_3.
Learning Mathematics “Asyik” with Youtube Educative Media
Authors: Sari W N , Samosir B S , Sahara N , Agustina L , Anita Y 
Published: April 2020

Abstract
The research aims to find out how the use of YouTube Educative as education media by students, parents, and teachers in improving knowledge, skills, and creativity generally in education and especially in mathematics studies. Besides that research also recommend YouTube Educative to help students so that learning mathematics becomes fun. This study applied descriptive qualitative research.This study applied descriptive qualitative research. The subjects of this study were the principal (headmaster), students and mathematics teachers. The object of this research was YouTube. The results of the study found that principal (headmaster), teachers, and students had not taken the advantages of YouTube as educative media in mathematics learning activities. Youtube is mostly used for playing games, watching cartoons, funny videos, arts and cooking recipes. Recommendation related to the use of YouTube Educative help students more easily understand concepts and learn mathematics becomes more fun.
Candidate Selection of Athletes Sparring for Boy Category Pencak Silat Using TOPSIS: Case Study in PSHT Pencak Silat
Authors: Putro Sigit Susanto , Santoso Wildan Romadhoni , Husni  , Rachmad Aeri 
Published: April 2020

Abstract
Pencak silat is one of the original cultures of the Indonesian people. But the general champion of the pencak silat branch is no longer dominated by Indonesia. Therefore, to be able to compete with other universities or overseas athletes, there needs to be a strict selection from each region. There are 22 criteria used for the selection of prospective sparring athletes. Therefore it is necessary to have a system that can facilitate the trainer to choose students to be sent to compete on behalf of the branches of each class. This study uses the TOPSIS (Technique For Order Preference By Similarity To Ideal Solution) method for student ranking and is selected as needed. Testing is done by the system and comparing the results of the competition from 12 sessions consisting of class A, class B, class C and class D with 42 athlete candidates. The suitability level of this application is 66.67%.
The Application of Genetic Algorithms as an Optimization Step in The Case of Nurse Scheduling at the Bringkoning Community Health Center
Authors: Mala Sari Rochman Eka , Rachmad Aeri , Imamah  , Santosa Iwan , Husni  
Published: April 2020

Abstract
Scheduling is an important activity that must be done in every job. In scheduling, there must be some rules that can minimize the occurrence of conflicts or gaps between schedules. In this study, applied a genetic algorithm to solve the problem of scheduling nurses in Bringkoning community health center. In the process of genetic algorithm, there are several processes that must exist until the creation of a result is a schedule. The number of nurses, population length, Cr and Mr values, and also number of iterations along with the number of days determined by input. The crossover method used is one cut-point crossover, Random mutation method and selected with elitism selection. Thereby, the analysis gained, is the value of the parameter genetic algorithm affects the optimization results. The small parameter size will cause the search area of the genetic algorithm to be narrower, whereas if the parameter size is too large it will require longer computing time and does not guarantee it will result in an optimal value for some of those variables. So, it depends on number of days in the input to get optimal result of the schedule for nursing care in the room of the emergency unit.

A post-publication change was made to this article on 20 Apr 2020 as the previously published article was a duplicate.