bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Activity of Some [(5-oxazolyl)-phenyl]-thiourea Derivatives
Authors: Zhong Zhaojin , Xing Guoling , Liu Jun , Zuo Limin , Zheng Zhihui , Li Yuhuan , Huo Ziwei , Gao Rongmei , Li Zhuorong 
Published: March 2020

Aims:Synthesis and biological evaluation of some [(5-oxazolyl)-phenyl]-thiourea derivatives as potential antiviral agents.Background:(5-Oxazolyl)-phenyl derivatives were derived from the design of mycophenolic acid structurally related analogues. The (5-oxazolyl)-phenyl fragment is an excellent composition for many novel structure compounds having good pharmaceutical properties, such as immunosuppressive, antiviral and anticancer. In the present study, we present combinations of thiourea group and (5-oxazolyl)-phenyl fragment. The antiviral activity, cytotoxicity and IMPDH activity of the title compounds were evaluated in vitro bioassay.Objective:[(5-Oxazolyl)-phenyl]-thiourea derivatives containing different substituted benzene rings were synthesized by introducing thiourea linker. All the synthesized derivatives were screened for their in vitro antiviral evaluation and inosine monophosphate dehydrogenase activity.Methods:A series of [(5-oxazolyl)-phenyl]-thiourea derivatives were synthesized by the reaction of thiocarbonyldiimidazole with amines. This was an effective method for introducing the thiourea group in the (5-oxazolyl)-phenyl structure. All of the synthesized derivatives were screened for their in vitro antiviral activity against influenza A virus, coxsackievirus B3, herpes simplex virus type 1 and inosine monophosphate dehydrogenase activity.Result:The results of the screening revealed that compounds 4i, 4j, 4k, 7m, 7n and 7o showed comparable activity towards IMPDH as compared to the control drug. Compounds 4k, 4l, 7m and 7n exhibited potent activity towards both RNA virus influenza A virus, coxsackievirus B3 and DNA virus HSV-1 at low micromolar concentrations. The activities of most compounds directly linked to the substituted benzene ring by the thiourea group were superior to those of the compounds which had the methylene linkage.Conclusion:The in vitro biological assays indicated that most of target molecules having combinations of thiourea group and (5-oxazolyl)-phenyl fragment exhibited antiviral activity and IMPDH activity compared the control drugs.
Bioprocess Optimization for Exopolysaccharides Production by Ganoderma lucidum in Semi-industrial Scale
Authors: Alsaheb Ramzy Abd , Zjeh Koh Zwin , Malek Roslinda Abd , Abdullah Jaafar Kamil , El Baz Ashraf , El Deeb Nehal , Dailin Daniel , Hanapi Siti Zulaiha , Sukmawati Dalia , El Enshasy Hesham 
Published: March 2020

Background:
For many years, Ganoderma was highly considered as biofactory for the
production of different types of bioactive metabolites. Of these bioactive compounds, polysaccharides
gained much attention based on their high biotherapeutic properties. Therefore, special attention
has been paid during the last years for the production of mushrooms bioactive compounds in a
closed cultivation system to shorten the cultivation time and increase the product yield.

Objective:
This work focuses on the development of a simple cultivation strategy for exopolysaccharides
(EPS) production using Ganoderma lucidum and submerged cultivation system.

Results and Discussion:
Therefore, this work is focused on the development of simple cultivation system for exopolysaccharides (EPS) production using Ganoderman lucidum. At first, the best medium supporting EPS production was chosen experimentally from the current published data. Second, like many EPS production process, carbon and nitrogen concentrations were optimized to support the highest production of polysaccharides in shake flask level. Furthermore, the process was scaled up in 16-L stirred tank bioreactor. The results clearly demonstrated that the best cultivation strategy was cultivation under controlled pH condition (pH 5.5). Under this condition the maximal volumetric and specific yield of EPS production were, 5.0 g/L and 0.42 g/g, respectively.

Methods:
For many years, Ganoderma was highly considered as biofactory for the
production of different types of bioactive metabolites. Of these bioactive compounds, polysaccharides
gained much attention based on their high biotherapeutic properties. Therefore, special attention
has been paid during the last years for the production of mushrooms bioactive compounds in a
closed cultivation system to shorten the cultivation time and increase the product yield.

Conclusion:
The current results clearly demonstrates the high potential use of submerged cultivation system as alternative to conventional solid state fermentation for EPS production by G. lucidum. Furthermore, optimization of both carbon and nitrogen sources concentration and scaling up of the process showed significant increase in both volumetric and specific EPS production.
Cross layer security solution for secure communication of sensors in Wireless Sensor Networks
Authors: Saini Rakesh , Kumar Naveen 
Published: March 2020

:
Safe direction-finding is extremely necessary for multihop wireless systems such as Wireless Sensor Networks. Multihop wireless systems are more defenseless to safety outbreaks as associated to single stage wireless networks. Cross layer design production a precise significant character for wireless sensor network submissions. Advanced security is actual significant for the achievement of announcement among sensor nodes in wireless sensor network because the numbers composed is regularly slight and the network is mostly susceptible. Numerous Security methods have been suggested to deliver safety resolutions beside numerous extortions to the Cross-layer modification techniques in Wireless sensor network. In this paper we overview the existing schemes for the security of cross-layer design in wireless sensor network. Proposed Security model will provide more security between sensor nodes and base station in wireless sensor network. Security is important for the success of the wireless sensor network because the data collected are often sensitive and the network is particularly vulnerable. In the cross-layer design, constraints are substituted between changed layers to protection well-organized use of energy. In this paper, we propose a secure security model that is based on cross layer design. It uses a cross layer optimization Mechanism. Reproduction consequences confirmation that our proposed safety model can achieve better in many situations and in unfriendly violence-disposed to situation.
EFFECT OF POTASH ADMINISTRATION ON THE BODY WEIGHT OF PREGNANT WISTAR RATS
Authors: VIDONA WB  , ADUEMA WADIONI  , AKUNNEH-WARISO C  , AMAH AK  
Published: March 2020

Objective: Potash known as potassium carbonate (K2CO3) is a mixture of salt with other components, including impurities which coexist in mineral and salt is highly consumed in various forms by pregnant women. The aim of this research is to determine the effect of potash on the weight index of pregnant Wistar rats.
Methods: A total of 25 albino Wistar rat with weights ranging from 180 to 300 g were used and allocated into five groups of five animals each (four females and one male) designated as Groups A, B, C, D, and E. The experimental Groups B, C, D, and E were administered through oral route different doses of potash of 300 mg/kg, 600 mg/kg, 900 mg/kg, and 1200 mg/kg, respectively, after pregnancy was detected by checking for mucus plug in the vagina. Group A served as the control group and was administered distilled water only. The animals were allowed for 1 week for acclimatization under normal temperature (270–300°C), which they were being fed with normal feed (grower’s mash) and water ad libitum for 1 week.
Results: The result showed a significant (p˂0.05) reduction in weight with the highest level seen with the 1200 mg/kg group when compared to the control.
Conclusion: Therefore, the effect of potash alters the physical activity and decreases weight, by implication may induce growth retardation of the Wistar rats which is not healthy for a pregnant animal.
ATIVIDADES PARA O ENSINO DE ONDAS SONORAS AOS ALUNOS SURDOS: UMA PROPOSTA INCLUSIVA. ACTIVITIES FOR THE EDUCATION OF SOUND WAVES TO DEAF STUDENTS: AN INCLUSIVE PROPOSAL
Authors: Braz Ruth Maria Mariani 
Published: March 2020

O projeto “Atividades para o Ensino de Ondas Sonoras” é uma proposta inclusiva que tem como objetivo possibilitar que os alunos surdos e ouvintes tenham as mesmas condições de assimilar o referido conteúdo, incluso no Currículo Mínimo de Física para o Ensino Médio. A metodologia utilizada foi o simulador PhET. Foram explorados os sentidos de tato e visão dos surdos. Esteve ainda disponível na sala de aula o apoio de uma intérprete da Língua Brasileira de Sinais. Foi neste contexto que os alunos puderam aprender através da exploração e da descoberta. A proposta foi aplicada com êxito entre alunos de uma escola pública, inseridos em diferentes séries dos Ensinos Fundamental e Médio. Tivemos como resultado o sucesso dos alunos surdos nesta aprendizagem, bem como o neologismo de dois sinais em LIBRAS: um para ultrassom e o outro para infrassom.
FORMAÇÃO ONLINE SOBRE DROGAS PARA DOCENTES NA PERSPECTIVA DA REDUÇÃO DE DANOS: O PONTO DE VISTA DOS CURSISTAS. ONLINE EDUCATION ON DRUGS FOR TEACHERS IN THE PERSPECTIVE OF DAMAGE REDUCTION: THE VIEW OF CURSISTS
Authors: Figueiredo Francisco José , Monteiro Simone Souza 
Published: March 2020

Pesquisas revelam que drogas circulam entre os jovens, mas diante do despreparo dos professores, o tema não é abordado nas escolas. Este estudo descreve um curso de formação online sobre drogas para docentes - informada pela perspectiva da Redução de Danos como modelo crítico e emancipatório - e as atividades educativas desenvolvidas na etapa final da formação. Apesar de ainda haver dúvidas sobre a concepção de redução de danos, os cursistas entrevistados promoveram espaços de diálogo e aprendizagem sobre drogas com suas turmas. Os resultados sugerem que o curso pode contribuir para a abordagem do tema entre estudantes.
JOGOS PEDAGÓGICOS E A INTERAÇÃO ENTRE ESTUDANTES DEFICIENTES VISUAIS E VIDENTES. PEDAGOGICAL GAMES AND THE INTERACTION BETWEEN SEERS AND VISUAL DISABLED STUDENTS.
Authors: Pimentel Andréa Guerra , Aragon Glauca Torres 
Published: March 2020

A obra de Vigotski discute os limites à participação social e cultural das pessoas com deficiências e propõe a criação de oportunidades educacionais que promovam a apropriação cultural por parte do educando com deficiência através da compensação social. Jogos pedagógicos podem favorecer a aprendizagem colaborativa e, se adaptados, podem estimular a troca de conhecimentos entre alunos com e sem deficiência visual. Um levantamento bibliográfico relativo a jogos pedagógicos acessíveis a deficientes visuais, no período de 2012 à 2016, com foco na área de Ciências Naturais revelou poucos artigos. Diante desta escassez, concluímos que o desenvolvimento e o uso de tais ferramentas ainda constitui um campo que requer atenção com o objetivo de promover uma efetiva inclusão escolar desses sujeitos.
NOTAS SOBRE CINEMA E EXPERIÊNCIA DE FORMAÇÃO ESTÉTICA NUMA PERSPECTIVA EMANCIPATÓRIA. NOTES ON CINEMA AND AESTHETIC TRAINING EXPERIENCE FROM AN EMANCIPATORY PERSPECTIVE
Authors: Pereira Márcia Ferreira Torres 
Published: March 2020

O artigo enfatiza estudos sobre estética, educação e imagens da arte, considera a reflexão filosófica acerca da realidade histórico-cultural contemporânea, do conceito e do sentido da formação estética como possibilidade de emancipação humana, na trajetória dos teóricos: Aumont; Badiou; Haroche e Aubert; Kracauer; Schiller; Wulf; Adorno; Horkheimer e Benjamin. A estética como conhecimento histórico exige reflexão, considera as percepções sensíveis, propõe uma educação crítica e a busca pelo conhecimento capaz de oportunizar o movimento do pensamento ético e político na condução de outros conhecimentos. O estudo sobre o cinema, como manifestação artística, abarca aspectos filosóficos e estéticos no contexto de suas relações com o saber e sua contribuição para o processo de formação.
PRECONCEITO ÉTNICO E RELIGIOSO NA ESCOLA: (DES)HUMANIZAÇÃO E BARBÁRIE ETHINIC OR RELIGIOUS PREJUDICE IN SCHOOL: BARBARISM OR (DE)HUMANIZATION
Authors: Quintana Eduardo 
Published: March 2020

Os resultados apresentados fazem parte de um estudo mais abrangente sobre a relação das religiões de matrizes africanas e a escola. Os dados aqui apresentados apontam para situações de intolerância religiosa na escola, em especial, ao enfocar a implementação Lei nº10.639/03 e da Resolução CNE/CP nº 1/2004. São dados que trazem a realidade do “chão da escola” e apontam para a relação tensionada entre pares no que diz respeito à orientação reli giosa, onde a escola não coíbe práticas e manifestações de intolerância às religiões de matrizes africanas. The results presented are part of a broader study on the relationship of african-based religions and school. The data presented here point to religious intolerance situations at school, in particular by focusing on the implementation of Lei nº10.639/03 and Resolution CNE/CP Nº 1/2004. Is data that bring the reality of "ground school" and point to the strained relationship between peers with regard to religious orientation, where the school does not shy away practices and manifestations of intolerance religions of african-based religions.
DIMENSÃO ESTÉTICA E PROCESSOS IDENTITÁRIOS NO PERCURSO DE SE FAZER PROFESSOR. AESTHETIC DIMENSION AND IDENTITY PROCESSES IN THE TEACHER'S ROUTE.
Authors: Ogêda Adrianne , Herig Daniela , Mazzi Iasmine , Camillo Keila , Sabóia Lia 
Published: March 2020

Apresentamos aspectos da dinâmica metodológica de uma experiência formativa desenvolvida como parte do projeto de pesquisa e extensão “Corpo, arte e natureza: investigando metodologia de formação de professores”. Fundamenta-se numa concepção de formação em que se integram sensibilidade, corporeidade e experiências estéticas. O público alvo foram os estudantes de graduação, em sua maioria do curso de Pedagogia da universidade em que atuamos. Nosso interesse nesse artigo é anunciar suas bases com vistas a refletir sobre as estratégias que têm sido mobilizadas, seus limites e possibilidades. Consideramos que essa ação se constitui como uma estratégia biopolítica voltada para formação docente, uma vez que em sua configuração metodológica rompe com os ditames referentes à lida com o espaço e o tempo que costumam organizar e direcionar as práticas instituídas nos modelos usuais de “aula”.We present aspects of the methodological dynamics of a formative experience developed as part of the research project and extension "Body, art and nature: investigating teacher training methodology". It is based on a conception of formation in which sensibility, corporeity and aesthetic experiences are integrated. The target audience were undergraduate students, mostly from the Pedagogy course of the university in which we operate. Our interest in this article is to announce its foundations in order to reflect on the strategies that have been mobilized, their limits and possibilities. We consider that this action constitutes a biopolitical strategy aimed at teacher training, since in its methodological configuration it breaks with the dictates referring to the space and time that usually organize and direct the practices instituted in the usual models of "class”.
DA EDUCAÇÃO INFANTIL AO ENSINO FUNDAMENTAL – APONTAMENTOS SOBRE A FORMAÇÃO DOCENTE AOS ACONTECIMENTOS COMO POTENCIALIDADE PARA OS ENCONTROS E SENTIDOS FROM CHILDREN EDUCATION TO FUNDAMENTAL TEACHING - PRESENTATIONS ON TEACHER TRAINING TO EVENTS AS POTENTIALITY FOR MEETINGS AND MEANINGS
Authors: Da Cruz Letícia Santos 
Published: March 2020

O texto apresentado toma como ponto de partida o processo transitório da Educação Infantil para o Ensino Fundamental a fim de compreender como a formação pode contribuir para o estabelecimento de diálogos. Baseia-se nas contribuições de Cruz (2012) e Saviani (2007) para abordar o caráter da pedagogia em sua dimensão teórica e prática e, Nóvoa (2017), no sentido de olharmos para a prática docente comoposições entre os sujeitos e seus conhecimentos, assim como em demais autores relevantes. Propõe que a prática docente, no processo de transição da Educação Infantil para o Ensino Fundamental, instaure possibilidades significativas , configurando-se como acontecimentos em transição e nestes, estabeleça potencialidades da prática nos encontros em espaços de enunciações. The text presented takes as a starting point the transitional process from Early Childhood Education to Elementary Education in order to understand how training cancontribute to the establishment of dialogues. It is based on the contributions of Cruz (2012) and Saviani (2007) to approach the character of pedagogy in its theoretical andpractical dimension, in Nóvoa (2017) in order to look at teaching practice as positions between subjects and their knowledge, as well as in other relevant authors. It proposes that the teaching practice in the process of transition from Early Childhood Education to Elementary Education establishes significant possibilities as events in transition, in these, the potentiality of practice lies in the meetings in spaces of enunciations.
PROCESSOS FORMATIVOS E POLÍTICAS EDUCACIONAIS NA PERSPECTIVA DA INCLUSÃO: ELEMENTOS PARA REFLEXÃO EDUCATIONAL PROCESSES AND POLICIES IN THE PERSPECTIVE OF INCLUSION: ELEMENTS FOR REFLECTION
Authors: Castro Luciana , Santiago Mylene Cristina 
Published: March 2020

Este ensaio discute a relação entre formação, valorização do magistério e o processo de inclusão em educação. O Atendimento Educacional Especializado e as políticassubjacentes à sua implementação são abordados, considerando a fragilidade decorrente da formação e a excessiva responsabilização docente. Com o intuito deapresentar proposições às barreiras identificadas, apoiamo-nos em documentos oficiais e em experiências nacionais e internacionais, tais como o ensino colaborativo. Por fim, tecemos breves considerações no sentido de pensar uma política de formação que considere a escola e seu cotidiano como lócus privilegiado para a construção de culturas, políticas e práticas de inclusão, que busque romper com asbarreiras de aprendizagem e participação dos estudantes com e sem deficiência. This essay discusses the relationship between training, valorization of the teaching profession and the process of inclusion in education. The Specialized EducationalAssistance and the policies underlying its implementation are addressed, considering the fragility of training and excessive teacher accountability. In order to present propositions to the identified barriers, we rely on official documents and national and international experiences, such as collaborative teaching. Finally, we make brief considerations in the sense of thinking about a training policy that considers the school and its daily life as a privileged locus for the construction of cultures, policies and practices of inclusion, that seeks to break the barriers of learning and participation of students with and without disabilities.
CULTURAS, EDUCAÇÃO E CORPO EM MOVIMENTO – POTENCIALIDADES DA ESCOLA CULTURES, EDUCATION AND BODY IN MOVEMENT - POTENTIALITIES FROM SCHOOL
Authors: Fernandes Andrea Da Paixão , Sanfilippo Lucio Bernard 
Published: March 2020

O presente artigo propõe refletir e dialogar sobre as temáticas educação, culturas e corpo a partir do lugar da escola como espaço privilegiado para o desenvolvimentodessa inter-relação. Entendemos as culturas como relevantes para a valorização e preservação de diferentes costumes, bem como para que percebamos, em sua dinâmica, potencialidades e possibilidades outras de produção de conhecimentos. Consideramos os movimentos e processos educativos e culturais – sobretudo nas culturas populares – que envolvam corpos, saberes, redes, na constituição de umaescola outra que se abra às diversidades que transbordam pelos diferentes espaços, dentro e fora de seus muros. This article proposes to reflect on and to dialogue with the theme of education, cultures and body taking into consideration the school as a privileged space a privileged space for the development of this interrelation. We understand cultures as being relevant to the valuation and preservation of different habits, as well as perceiving their dynamics, other potentialities and possibilities of knowledgeproduction. We consider the educational and cultural movements and processes – especially in popular cultures – that involve bodies, knowledge, and networks in themaking up of a school that opens itself up to the diversities that overflow the different spaces, inside and outside its walls.
Evaluation of Factors Related to Glycemic Management in Professional Cyclists With Type 1 Diabetes Over a 7-Day Stage Race
Authors: Scott Sam N. , Christiansen Mark P. , Fontana Federico Y. , Stettler Christoph , Bracken Richard M. , Hayes Charlotte A. , Fisher Miles , Bode Bruce , Lagrou Peter H. , Southerland Phil , Riddell Michael C. 
Published: March 2020

OBJECTIVE
To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race.

RESEARCH DESIGN AND METHODS
An observational evaluation of possible factors related to glycemic management and performance in six male professional cyclists with type 1 diabetes (HbA1c 6.4 ± 0.6%) during the 2019 Tour of California.

RESULTS
In-ride time spent in euglycemia (3.9–10.0 mmol/L glucose) was 63 ± 11%, with a low percentage of time spent in level 1 (3.0–3.9 mmol/L; 0 ± 1% of time) and level 2 (&lt;3.0 mmol/L; 0 ± 0% of time) hypoglycemia over the 7-day race. Riders spent 25 ± 9% of time in level 1 (10.1–13.9 mmol/L) and 11 ± 9% in level 2 (&gt;13.9 mmol/L) hyperglycemia during races. Bolus insulin use was uncommon during races, despite high carbohydrate intake (76 ± 23 g ⋅ h−1). Overnight, the riders spent progressively more time in hypoglycemia from day 1 (6 ± 12% in level 1 and 0 ± 0% in level 2) to day 7 (12 ± 12% in level 1 and 2 ± 4% in level 2) (χ2[1] &gt; 4.78, P &lt; 0.05).

CONCLUSIONS
Professional cyclists with type 1 diabetes have excellent in-race glycemia, but significant hypoglycemia during recovery overnight, throughout a 7-day stage race.
Nesnelerin İnterneti (IoT) ve Kablosuz Algılayıcı Ağların Güvenliğine Yapılan Saldırıların Tespit Edilmesi ve Önlenmesi
Authors: TAŞ Oğuzhan , KİANİ Farzad 
Published: March 2020

IoT (Internet of Things) ya da diğer adıyla Nesnelerin İnterneti kavramı,
internete bağlanan ve diğer cihazlarla iletişimde olan her nesneyi
kapsamaktadır. Artık hayatımızın bir parçası haline gelecek otonom araçlar,
akıllı buzdolabılar, akıllı çamaşır makineleri, akıllı tost makineleri, akıllı
saatler gibi birçok IoT cihazı birbiriyle farklı kablosuz ağ teknolojilerini kullanarak
haberleşebilirler. IoT cihazların birçok kritik alanda kullanılmasıyla
birlikte IoT güveniğine karşı yapılan saldırılar artmıştır. Bu saldırılar IoT katmanlarına yapılarak veri gizliliği,
veri bütünlüğü, veri tazeliği, veri erişilebilirliği, kimlik doğrulama gibi
kriterler ihlal edilebilmektedir. Bu saldırıları önlemek amacıyla birçok
güvenlik çözümü önerilmiştir, fakat sınırlı enerji, kısıtlı batarya süresi, zayıf işlemci gücü ve
sınırlı hafıza gibi sınırlamalardan dolayı düşük güçlü IoT cihazlar üzerinde geleneksel
güvenlik yöntemlerinin uygulanması mümkün değildir. Bu çalışmada, IoT
cihazların güvenliğini tehdit eden saldırılar incelenerek, ağ katmanlarına göre
detaylı şekilde sınıflandırılmış ve savunma
teknikleri önerilmiştir.