bluuebunny/crossref_metadata_2025_split huggingface dataset:
The awareness rate of mental health knowledge Among Chinese adolescent
Authors: Guo Shengyu , Yang Yan , Liu Feiyue , Li Fuying 
Published: February 2020

Abstract

Background:
Mental health knowledge is an important part of mental health literacy, which is related to one's attitude and coping style when facing mental illness. The awareness rate of mental health knowledge among adolescents is an effective index to evaluate the effect of school mental health education, and the awareness rate of mental health knowledge among Chinese adolescents has not been effectively evaluated.

Methods:
Two electronic databases for English language and 3 electronic databases for Chinese language were searched for relevant studies. Meta-analysis was conducted to analyze the awareness rate among Chinese adolescents. The normal distribution test was conducted using 5 methods. Homogeneity test was conducted, and I
2 > 50% indicates existence of heterogeneity and in this case, the random model was adopted; otherwise, we adopt the fixed model. Funnel plot and Egger test was used to confirm whether publication bias existed.

Results:
Seventeen studies were included in this study, comprising 22,164 students from different stages of education (10,437 senior middle-school students, 5589 junior middle-school students, and 6138 college students). The awareness rate of mental health knowledge among Chinese adolescents was only 66%; for university students and middle-school students, their awareness rate was 73% and 61%, respectively. The awareness rate among senior middle-school students was as low as that of junior middle-school students. The awareness rate among college students in developed regions was higher than that in developing regions.

Conclusions:
The awareness rate of mental health knowledge among Chinese adolescents was lower than the goal set in the national mental health work plan. There are gaps in mental health education in different developed areas. The mental health education among adolescent in Chinese mainland needs to be further strengthened.
Impact of 68Ga-DOTATOC PET/CT in comparison to 111In-Octreotide SPECT/CT in management of neuro-endocrine tumors
Authors: Tolomeo Anna , Lopopolo Gaetano , Dimiccoli Vincenzo , Perioli Luana , Modoni Sergio , Scilimati Antonio 
Published: February 2020

Abstract

Rationale:
In the diagnostics of neuroendocrine tumors (NETs), scintigraphy and Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) with 111Indium-Octreotide occupy a prominent place.
The introduction in clinical practice of 68Gallium-labelled somatostatin analogues (DOTA-TOC, DOTA-TATE, DOTA-NOC) for Positron Emission Tomography/Computed Tomography (PET/CT), significantly improved NETs diagnostics due to greater sensitivity and improved lesion detection in addition to better patient convenience and decreased radiation dose.

Patient concerns:
We report a case of a patient who was diagnosed with a neuroendocrine tumor of the ileocecal valve.

Diagnoses:
Diagnosis was made by ultrasonography, CT, and colonoscopy. Hystology after surgery was G2 NET of ileo-cecal valve. Restaging was carried out by 111In-Octreotide SPECT/CT and, 1 month later, by 68Ga-DOTATOC PET/CT. 18F-FDG PET/C was also carried out.

Interventions:

68Ga-DOTATOC PET/CT showed larger disease that modified disease management from surgery to medical treatment.

Outcomes:
After an initial improvement in the patient clinical condition, the tumor caused a worsening with the appearance of ascites.

Lessons:

68Ga-DOTA-conjugate PET/CT is appropriate in low and intermediate NET (Ki67 index respectively ≤3% and 3%–20%) characterized by better survival and better response after Peptide Receptor Radionuclide Therapy.

18F-FDG is mostly useful in high grade (G3) of disease, so that 68Ga-DOTA-conjugate SUV and 18F-FDG SUV have an opposite trend in relation to the tumor grade. 68Ga-DOTATOC PET/CT changes, as in our case, therapeutic management in about 40% of cases.
Primary retroperitoneal germ cell tumor in an adult female
Authors: Lou Qitian , Wang Weigen , Liang Wenjie 
Published: February 2020

Abstract

Rationale:
Primary retroperitoneal germ cell tumors are uncommon and especially rare in female patients. However, this type should be included in the differential diagnosis of retroperitoneal tumors that may metastasize from the gonads and be a primary tumor.

Patient concerns:
An abdominal mass was detected in a 38-year-old woman during physical examination, which was accompanied by left renal obstructive hydrops. She was admitted to our institution for further investigation. The patient had no obvious clinical symptoms, and the levels of serum tumor markers did not signifificantly increase. Abdominal noncontrast enhanced and contrast-enhanced computed tomography revealed a retroperitoneal neoplasm that invaded the left ureter, thereby causing left hydronephrosis.

Diagnoses:
Imaging examination characterized the tumor as malignant based on its invasion in the left ureter. Histopathology and immunohistochemistry confifirmed the resected tumor as a dysgerminoma. The primary gonad-derived germ cell tumor was not found in the pelvis; therefore, the patient was fifinally diagnosed with primary retroperitoneal germ cell tumor.

Interventions:
Preoperative examination was completed, and the retroperitoneal mass was resected.

Outcomes:
During the short-term follow-up, no tumor recurrence was detected.

Lessons:
Primary retroperitoneal seminoma should be included in the differential diagnosis of primary retroperitoneal tumors in female patients. The primary retroperitoneal seminoma/anaplastic tumor has an obvious occupying effect and can easily invade the surrounding structures. However, surgical resection of such tumors is an optional treatment strategy.
Breakage and migration of a high-speed dental hand-piece bur during mandibular third molar extraction
Authors: Matsuda Shinpei , Yoshimura Hitoshi , Yoshida Hisato , Sano Kazuo 
Published: February 2020

Abstract

Rationale:
Tooth extraction is a common dental surgical procedure. There is a possibility that various complications often occur during third molar tooth extractions.

Patient concerns:
The authors report herein 2 cases of migration of a high-speed dental hand-piece bur during mandibular third molar extraction—one case with the iatrogenic foreign body migrating into the mandibular body and another case with the iatrogenic foreign body migrating into the floor of mouth are reported.

Diagnosis:
The patient was diagnosed with the iatrogenic foreign body associated with mandibular third molar extraction by imaging examinations.

Interventions:
The authors performed elective surgery to remove the foreign body under general anesthesia in Case 1, and performed emergency surgery to remove the foreign body under local anesthesia in Case 2.

Outcomes:
The foreign bodies were removed, and complete removal of the foreign bodies was confirmed by postoperative x-ray examination. The patients’ postoperative courses were uneventful.

Lessons:
The selection of adequate surgical procedures and instruments will prevent the occurrence of iatrogenic foreign bodies. If migration accidents occur, their positions should first be confirmed by imaging examinations. Dentists and/or oral surgeons should perform removal operations considering the degree of emergency based on the results of imaging examinations.
Treatment of conjunctival papilloma with topical interferon alpha-2b - case report
Authors: Bolek Bartłomiej , Wylęgała Adam , Teper Sławomir , Kokot Joanna , Wylęgała Edward 
Published: February 2020

Abstract

Rationale:
Conjunctival papilloma is a benign neoplastic lesion of epithelial origin, with a minimal tendency toward malignancy and an exophytic growth type. Etiological factors that contribute to the appearance of papilloma are UV exposure, HPV infection, smoking, and immunodeficiency. A case report of limbal conjunctival papilloma treatment with topical interferon alpha-2b eye drops applied to the conjunctival sac.

Patient concerns:
A 49-year-old female patient treated in the Clinical Department of Ophthalmology for conjunctival lesion located in the temporal quadrant near the limbus of the right eye. Ocular examination of the patient's eye did not show any abnormalities: visual acuity—20/20, intraocular pressure—16 mmHg.

Diagnoses:
During physical examination, a broad-based pink lesion of size 4 mm × 6 mm was found in interpalpebral bulbar conjunctiva with prominent feeder vessels and soft consistency. Lesion in the biomicroscopic examination did not show any sign of malignancy. In Swept Source Optical Coherence Tomography (SS-OCT) there was no sign of infiltration into sclera or cornea. In vivo confocal microscopy (IVCM) examination, revealed loss of the normal conjunctival epithelium - hyper-reflective cells, variation of cell size. A clinical diagnosis of limbal conjunctival papilloma was made.

Interventions:
Interferon alpha-2b 1 million IU/ml eye drops were applied 4 times a day for 5 months. The treatment lasted 5 months without changing the dosing regimen. Three months after the start of the interferon treatment, a complete regression of the lesion was achieved. Treatment was continued for the following 2 months. Controlled IVCM after 6 months showed only few hyper-reflective cells and fibrotic tissue.

Outcomes:
Treatment of conjunctival papilloma with topical interferon alpha-2b led to the complete regression of the lesion. Although after the therapy the conjunctiva appears normal both in slit lamp and in the OCT examination, there is a noticeable fibrosis of the tissue in confocal microscopy. During the 14-month follow-up period, there were no recurrent lesions.

Lessons:
In this study, topical interferon alpha-2b has been shown to be an effective and safe therapy for small-to-medium-size conjunctival papilloma without any sign of malignancy.
Relationship between plasma levels of 25-hydroxyvitamin D and arterial stiffness in elderly Chinese with non-dipper hypertension
Authors: Gu Jian-Wei , Liu Ju-Hua , Xiao Hui-Neng , Yang Yun-Feng , Dong Wen-Ju , Zhang Quan-Bo , Liu Li , He Cheng-Shi , Wu Bi-Hua 
Published: February 2020

Abstract
Elderly individuals with non-dipper hypertension are at high risk of cardiovascular disease because of increased stiffness of peripheral arteries. Since, vitamin D deficiency is prevalent in elderly Chinese. We examined whether reduced plasma levels of 25-hydroxyvitamin D [25(OH)D] may help promote this stiffness.
Hypertensive patients at least 60 years old without history of peripheral arterial disease at our hospital were retrospectively divided into dipper and non-dipper groups according to the results of 24-hour ambulatory blood pressure monitoring. Plasma levels of 25(OH)D were measured by enzyme immunoassay. Peripheral arterial stiffness was measured based on the cardio-ankle vascular index (CAVI).
Of the 155 patients enrolled, 95 (61.3%) were diagnosed with non-dipper hypertension and these patients had significantly lower plasma levels of 25(OH)D than the 60 patients with dipper hypertension (19.58 ± 5.97 vs 24.36 ± 6.95 nmol/L, P < .01) as well as significantly higher CAVI (8.46 ± 1.65 vs 7.56 ± 1.08 m/s, P < .01). Vitamin D deficiency was significantly more common among non-dipper patients (57.9% vs 31.7%, P < .01). Multivariate regression showed that age and 25(OH)D were independently related to CAVI, with each 1-ng/ml decrease in 25(OH)D associated with a CAVI increase of +0.04 m/s.
Non-dipper hypertension is associated with vitamin D deficiency and reduced plasma levels of 25(OH)D. The latter may contribute to stiffening of peripheral arteries, increasing the risk of cardiovascular disease.
Intrauterine double-balloon tamponade vs gauze packing in the management of placenta previa
Authors: Wei Jing , Dai Yimin , Wang Zhiqun , Gu Ning , Ju Hongfang , Xu Youdi , Xu Biyun , Hu Yali 
Published: February 2020

Abstract

Background:
To evaluate the effectiveness and safety of a newly designed intrauterine double-balloon catheter to arrest postpartum hemorrhage (PPH) following cesarean delivery (CD) for placenta previa.

Methods:
We conducted an open-label, multicenter randomized controlled trial in two referral centers and one general hospital. Women with continuous bleeding after placental delivery following CD for placenta previa, who failed to respond to uterotonics, suturing and uterine devascularization, and in the absence of suspected deeply invasive accreta were eligible subjects. Eligible subjects were randomized to receive intrauterine double-balloon catheter (n = 102) or gauze packing (n = 102). The main outcome was the rate of successful hemostasis without the need for additional surgical interventions. The secondary outcomes included the volume of blood loss during and after CD, the rate of PPH, incidence and amount of blood transfusion, hysterectomy, surgical complications, intensive care unit admission, need for re-laparotomy, length of hospital stay, and readmission.

Results:
The 224 participants were recruited before delivery, with 20 excluded (14 cases bleeding stopped after uterotonics and/or local myometrium sutures and 6 patients with placental increta). Finally, 102 women were assigned in catheter group and 102 others in gauze group. There was no difference in the rate of successful hemostasis in the catheter and gauze groups (93.1% vs 91.2%, P = .80). Compared with those in the gauze group, women in the catheter group showed significantly less blood loss within 24 hours postpartum (895 [612.3–1297.8] vs 1156 [882.5–1453.3] ml, P < .01), lower rate of PPH ≥1000 ml (42.2% vs 63.7%, P < .01). Accordingly, women in the catheter group had significantly less maternal adverse events such as postpartum anemia, puerperal morbidity, and postpartum pain.

Conclusion:
Uterine tamponade using a double-balloon catheter was as effective as gauze packing in hemostasis, and appeared to be superior in reducing postpartum blood loss and pain following CD for placenta previa. Using double-balloon catheter in managing PPH in this situation may be a preferable alternative to minimize maternal morbidity.
Payment for Contraceptive Services in Safety Net Clinics
Authors: Darney Blair G. , Biel Frances M. , Rodriguez Maria I. , Jacob R. Lorie , Cottrell Erika K. , DeVoe Jennifer E. 
Published: February 2020

Objectives:
We describe payor for contraceptive visits 2013–2014, before and after Medicaid expansion under the Affordable Care Act (ACA), in a large network of safety-net clinics. We estimate changes in the proportion of uninsured contraceptive visits and the independent associations of the ACA, Title X, and state family planning programs.

Methods:
Our sample included 237 safety net clinics in 11 states with a common electronic health record. We identified contraception-related visits among women aged 10–49 years using diagnosis and procedure codes. Our primary outcome was an indicator of an uninsured visit. We also assessed payor type (public/private). We included encounter, clinic, county, and state-level covariates. We used interrupted time series and logistic regression, and calculated multivariable absolute predicted probabilities.

Results:
We identified 162,666 contraceptive visits in 219 clinics. There was a significant decline in uninsured contraception-related visits in both Medicaid expansion and nonexpansion states, with a slightly greater decline in expansion states (difference-in-difference: −1.29 percentage points; confidence interval: −1.39 to −1.19). The gap in uninsured visits between expansion and nonexpansion states widened after ACA implementation (from 2.17 to 4.1 percentage points). The Title X program continues to fill gaps in insurance in Medicaid expansion states.

Conclusions:
Uninsured contraceptive visits at safety net clinics decreased following Medicaid expansion under the ACA in both expansion and nonexpansion states. Overall, levels of uninsured visits are lower in expansion states. Title X continues to play an important role in access to care and coverage. In addition to protecting insurance gains under the ACA, Title X and state programs should continue to be a focus of research and advocacy.
Risk Factors Influencing Tolerance and Clinical Features of Food Protein–induced Allergic Proctocolitis
Authors: Buyuktiryaki Betul , Kulhas Celik Ilknur , Erdem Semiha B. , Capanoglu Murat , Civelek Ersoy , Guc Belgin Usta , Guvenir Hakan , Cakir Murat , Dibek Misirlioglu Emine , Akcal Omer , Volkan Burcu , Toyran Muge , Sag Elif , Kertel Alev C. , Ginis Tayfur , Kocabas Can N. , Orhan Fazıl , Can Demet 
Published: February 2020

ABSTRACTObjective:Continued progress in our understanding of the food protein–induced allergic proctocolitis (FPIAP) will provide the development of diagnostic tests and treatments. We aimed to identify precisely the clinical features and natural course of the disease in a large group of patients. Also, we investigated the predicting risk factors for persistent course since influencing parameters has not yet been established.Methods:Infants who were admitted with rectal bleeding and had a diagnosis of food protein–induced allergic proctocolitis in 5 different allergy or gastroenterology outpatient clinics were enrolled. Clinical features, laboratory tests, and prognosis were evaluated. Risk factors for persistent course were determined by logistic regression analyses.Results:Among the 257 infants, 50.2% (n = 129) were girls and cow's milk (99.2%) was the most common trigger. Twenty‐four percent of the patients had multiple food allergies and had more common antibiotic use (41.9% vs 11.8%), atopic dermatitis (21% vs 10.2%), wheezing (11.3% vs 1.5%), colic (33.8% vs 11.2%), and IgE sensitization (50% vs 13.5%) compared to the single‐food allergic group (P < 0.001, P = 0.025, P = 0.003, P < 0.001, respectively). In multivariate logistic regression analysis, presence of colic (odds ratio [OR]: 5.128, 95% confidence interval [CI]: 1.926–13.655, P = 0.001), IgE sensitization (OR: 3.964, 95% CI: 1.424–11.034, P = 0.008), and having allergy to multiple foods (OR: 3.679, 95% CI: 1.278–10.593, P = 0.001] were found to be risk factors for continuing disease after 1 year of age.Conclusion:Although most children achieve tolerance at 1 year of age, IgE sensitization, allergy to multiple foods, and presence of colic were risk factors for persistent course and late tolerance. In this context, these children may require more close and extended follow‐up.
Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Infliximab in Pediatric Inflammatory Bowel Disease
Authors: Winter Dwight A. , Joosse Maria E. , de Wildt Saskia N. , Taminiau Jan , de Ridder Lissy , Escher Johanna C. 
Published: February 2020

ABSTRACTObjectives:Infliximab (IFX), a monoclonal antibody directed against tumor necrosis factor alpha is a potent treatment option for inflammatory bowel disease (IBD). Dosing regimens in children are extrapolated from adult data using a fixed, weight‐based dose, which is often not adequate. While clinical trials have focused on safety and efficacy, there is limited data on pharmacokinetic characteristics and immunogenicity of IFX in children. The objective was to provide a systematic overview of current literature on pharmacokinetic and immunogenicity of IFX in children with IBD, to assess the validity of current adult to pediatric dosing extrapolation.Methods:A literature search identified publications up to October 2018. Eligibility criteria were study population consisting of children and/or adolescents with IBD, report of IFX trough levels and/or antibodies‐to IFX, full text article or abstract, article in English, and original data.Results:Initial electronic search yielded 2360 potentially relevant articles, with 1831 remaining after removal of duplicates. An additional search yielded another 202 potentially relevant articles. Of the 2033 retrieved articles, 2000 articles were excluded based on title, abstract, or eligibility criteria. Clearance of IFX was increased in young children and children with extensive disease, leading to lower trough levels after extrapolated dosing of 5 mg/kg, antibodies‐to IFX emergence, and subsequent reduced efficacy.Conclusions:Adult to pediatric weight–based dosing extrapolation is often inadequate. We provide several considerations for optimal dosing of IFX in children and adolescents with IBD.
Influence of the 2012 European Guidelines in Diagnosis and Follow‐up of Coeliac Children With Selective IgA Deficiency
Authors: López Raquel Vecino , Cid Carmen Miranda , García Gloria Rodrigo , Romero Ruth García , Cilleruelo Maria Luz , Riechmann Enriqueta Román ,   Spanish Working Group on Coeliac Disease (Spanish Society of Paediatric Gastroenterology, Hepatology, Nutrition, SEGHNP)
Published: February 2020

ABSTRACTObjectives:The aim of the study was to describe diagnostic criteria used in children with coeliac disease (CD) and selective IgA deficiency; to determine if the publication of the 2012 ESPGHAN criteria prompted any changes; to evaluate the evolution of serological markers.Methods:Multicenter, retrospective, descriptive study of a cohort of children under 15 years with selective IgA deficiency diagnosed with CD (January 2006 to December 2016). Demographic, clinical, genetic, histological and IgG‐based antibodies were collected at diagnosis and follow‐up.Results:Eighty‐six children were included, 60 diagnosed after the guide. Two groups were established: G1 (n = 63) and G2 (n = 23) with or without diagnostic biopsy respectively. In G1: 87.3% were symptomatic, 87.3% had human leukocyte antigan (HLA) DQ2/DQ8 typing (all positive), all had IgG serology positive (71.5% ATG, 35% EMA, 19% DPG, 9.5% AGA), and all had villous atrophy (Marsh‐Oberhuber 2–3). Follow‐up data were available in 58 children, 34 after 2 years on a gluten‐free diet. Fifty‐two percentage remained ATG IgG‐positive despite good dietary adherence and symptom remission. Regarding G2: all were diagnosed post‐2012, had typical symptoms, HLA DQ2/DQ8 positive and ATG IgG × 10 ULN. Additionally, EMA IgG was performed in 14 (60%), all positive.Conclusions:In our cohort of children with selective IgA deficiency and diagnosed with CD, children without a diagnostic biopsy suggests that IgG serology was considered the equivalent as IgA isotype, even when this is not addressed in the aforementioned guidelines. Great heterogeneity was observed in the IgG serology used at diagnosis. After 2 years of a gluten‐free diet, half of children remained with a positive serology.