bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Monoclonal Antibodies targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with Bortezomib/Immunomodulators plus Dexamethasone/Prednisone for the treatment of Multiple Myeloma: An Indirect-Comparison Meta-Analysis of Randomized Controlled Trials
Authors: Ye Wu , Wu Xia , Liu Xiaoyan , Zheng Xue , Deng Jili , Gong Yuping 
Published: December 2020

Abstract
Background

In recent years, there were many clinical trials assessed the efficacy and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisoneare for the treatment of multiple myeloma (MM). The treatment outcomes of comparing different MAbs in combination with above-mentioned agents remain unknown. We conducted this meta-analysis to compare indirectly the efficacy and safety of MAbs targeting CD38, SLAMF7 and PD-1/PD-L1 in combination with bortezomib/immunomodulators plus dexamethasone/ prednisone in patients with MM.
Methods

We electronically searched for randomized controlled trials (RCTs) in which at least one of the three MAbs was included among multiple arms. We included eleven eligible RCTs with 5367 patients in the meta-analysis. Statistical analysis used StataMP14 and Indirect Treatment Comparisons software.
Results

We synthesized hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS), relative risk (RR) for overall response rate, complete response (CR) or better, very good partial response (VGPR) or better, VGPR, partial response, stable disease and grade 3 or higher adverse events among the three groups. The HR for PFS of the CD38 group vs SLAMF7 group, CD38 group vs PD-1/PD-L1 group and SLAMF7 group vs PD-1/PD-L1 group were 0.662(95CI0.543-0.806), 0.317(95CI 0.221–0.454) and 0.479(95CI0.328-0.699) respectively. The HR for OS of the CD38 group vs SLAMF7 group was 0.812(0.584–1.127). The RR for CR or better in the CD38 group versus SLAMF7 group was 2.253(95CI1.284-3.955). The RR for neutropenia of the CD38 group versus SLAMF7 group was 1.818(95CI1.41-2.344).
Conclusions

Treatment with the CD38 group resulted in longer PFS and better treatment response than the SLAMF7 and PD-1/PD-L1 group. In addition, the SLAMF7 group prolonged PFS compared with the PD-1/PD-L1 group, and had a lower incidence of grade 3 or higher neutropenia than the CD38 and PD-1/PD-L1 group. In
Immune Prognostic Implications of PSMD14 and its Associated Genes Signatures in Hepatocellular Carcinoma
Authors: chuan tian , Mubalake Abudoureyimu , xinrong Lin , hao Zhou , Xiaoyuan Chu , Rui Wang 
Published: December 2020

Abstract
Background: PSMD14 played a vital roles initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Therefore, we aimed to explore gene signatures and immune prognostic values of PSMD14 and its-related genes in HCC.Methods: Analyzed the expression of PSMD14 in multiple databases, and clinicopathologic characteristics associated with PSMD14 overall survival using Wilcoxon signed-ranktest, logistic and Cox regression, Kaplan-Meier method. An immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) was constructed and validated using the co-expression and cox regression analyses in TCGA, ICGC and TIMER datasets and CIBERSORT computational methods. Gene Set Enrichment Analysis (GSEA) was performed using TCGA data set. RT-PCR further validates the expression of seven immune genes in Hepatocellular carcinoma cells.Results: Increased PSMD14 expression in HCC was significantly associated with poor prognosis and clinicopathologic characteristics (grade, histologic stage, surgical approach and T stage, all p-values < 0.05 ). A total of six PSMD14-related genes were detected, which markedly related to overall survival and immune infiltrating levels in HCC patients. Using cox regression analysis, the PSMD14 and its-related genes were found to be an independent prognostic factor for HCC survival. Calibration curves confirmed good consistency between clinical nomogram prediction and actual observation. Immune prognostic model suggests that patients in the high‐risk group shown significantly poorer survival than patients in the low‐risk group.Conclusion: We screened potential immune prognostic genes and constructed and verified a novel PSMD14-based prognostic model of HCC, which provides new potential prognostic biomarkers and therapeutic targets and lays a theoretical foundation for immunotherapy of HCC.
Can Intersectionality Help with Understanding and Tackling Health Inequalities? Perspectives of Professional Stakeholders
Authors: Holman Daniel , Salway Sarah , Bell Andrew , Beach Brian , Adebajo Adewale , Ali Nuzhat , Butt Jabeer 
Published: December 2020

Abstract
Background: The concept of ‘intersectionality’ is increasingly employed within public health arenas, particularly in North America, and is often heralded as offering great potential to advance health inequalities research and action. Given persistently poor progress towards tackling health inequalities, and recent calls to reframe this agenda in the UK and Europe, the possible contribution of intersectionality deserves attention. Yet, no existing research has examined professional stakeholder understandings and perspectives on applying intersectionality to this field. In this paper we seek to address that gap. Methods: drawing upon a consultation survey and workshop undertaken in the UK. The survey included both researchers (n=53) and practitioners (n=20) with varied roles and levels of engagement in research and evaluation. Topics included: familiarity with the term and concept ‘intersectionality’, relevance to health inequalities work, and issues shaping its uptake. Respondents were also asked to comment on two specific policy suggestions; targeting and tailoring interventions to intersectional sub-groups, and evaluating the intersectional effects of policies. 23 people attended the face-to-face workshop. The aims of the workshop were to: share examples of applying intersectionality within health inequalities research and practice; understand the views of research and practice colleagues on potential contributions and challenges; and identify potential ways to promote intersectional approaches Results: Findings indicated a generally positive response to the concept and a cautiously optimistic assessment that intersectional approaches could be valuable. However, opinions were mixed and various challenges were raised, especially around whether intersectionality research is necessarily critical and transformative and, accordingly, how it should be operationalised methodologically. Nonetheless, there was general agreement that intersectionality is concerned with diverse inequalities and the systems of power that shape them. Conclusions: In the UK health inequalities policy and practice context there are a number of potential ways forward for intersectionality in helping to understand and tackle such inequalities.
Environmental Drivers of Algal Metacommunity Structure in in River-Connected Lakes
Authors: Kim Min Sung , Ahn Seok Hyun , Jung In Jae , Lee Tae Kwon 
Published: December 2020

Abstract
The metacommunity approach provide insights into how the biological communities are assembled along the environmental variations. The current study presents the importance of water quality on the metacommunity structure of algal communities in six, river-connected lakes using long-term (8 years) monitoring datasets. Elements of metacommunity structure were analyzed to evaluate whether water quality structured the metacommunity across biogeographic regions in the riverine ecosystem. The algal community in all lakes was found to exhibit Clementsian or quasi-Clementsian properties, indicating that the communities responded to the environmental gradient. Reciprocal averaging clearly classified the lakes into three clusters according to the geographical region in river flow (upstream, midstream, and downstream). The dispersal patterns of algal species, including Aulacoseira, Cyclotella, Stephanodiscus, and Chlamydomonas across the regions also supported the spatial-based classification results. Although conductivity, chemical oxygen demand, and biological oxygen demand were found to be important variables (loading > |0.5|) of the entire algal community assembly, temperature was a critical factor in water quality associated with community assembly in each geographical area. These results support the notion that the structure of algal communities is strongly associated with water quality, but the relative importance of variables in structuring algal communities differed by geological regions.
Biologically effective doses of 60-70Gy vs. &gt;70Gy of stereotactic body radiotherapy (SBRT) combined with chemotherapy in locally advanced pancreatic cancer: protocol of a phase III study
Authors: Ye Yusheng , Zhu Xiaofei , Zhao Xianzhi , Jiang Lingong , Cao Yangsen , Zhang Huojun 
Published: December 2020

Abstract
Background: There is controversial on the correlation between biologically effective dose (BED, α/β=10) of stereotactic body radiation therapy (SBRT) and clinical outcomes of patients with locally advanced pancreatic cancer (LAPC). Therefore, the aim of the study is to compare the survival benefits of BED10 of 60-70Gy with those of BED10＞70Gy.Methods: This study is a multicenter study. Patients with LAPC are randomly allocated into two groups. Arm1: SBRT with BED10 of 60-70Gy in 5-6 fractions combined with gemcitabine plus albumin-bound paclitaxel; Arm2: SBRT with BED10＞70Gy in 5-6 fractions combined with gemcitabine plus albumin-bound paclitaxel. The primary outcome is progression-free survival (PFS). The secondary outcomes are radiation-induced gastrointestinal (GI) toxicity, local control (LC) and overall survival (OS).Discussion: The pilot phase Ⅲ study could provide evidence for further decision making of prescription doses of SBRT for LAPC, which may improve survival outcomes without compromise of quality of life. The trial protocol has been approved by the Ethics committee of Shanghai Changhai hospital. The ethics number is CHEC2020-100.Trial registration: Clinical trials number: NCT04603586. Date of registration: 10/27/2020.
Effects of the Timing of Labour Induction on Maternal and Neonatal Outcomes in Low-risk Nulliparous Chinese Women
Authors: WEI Qiang , CAO Qin-yan , ZHANG Li , XU Yi , DUAN Mei-fan 
Published: December 2020

Abstract
Backgroud: When labour induction should be offered to women at or beyond term is unclear. This work aimed to investigate the effects of the timing of labour induction on maternal and neonatal outcomes in low-risk pregnancies. Methods: This retrospective case-control study involved low-risk primigravid pregnant mothers in whom labour was induced at 40-41+6 weeks at our two hospitals between January and December 2017. According to the gestational age at labour induction, participants were categorized into the study group (40-40+6 weeks, n=284) or to the control group (41-41+6 weeks, n=172), and maternal and neonatal outcomes were compared.Results: The study group showed significantly shorter labour in the first stage (391.8±225.7 vs. 472.0±268.9 min, P=0.006), second stage (65.41±38.66 vs. 53.73±31.58 min, P= 0.008) and total stage (453.0±235.8 vs. 535.7±259.8 min, P=0.005). The two groups showed no significant differences in the methods of labour induction or in the rates of failure of labour induction, of caesarean delivery, of postpartum haemorrhage, or of admission to the neonatal intensive care unit.Conclusions: Our retrospective study suggests that inducing labour at 40-40+6 weeks does not increase the risk of adverse maternal or foetal outcomes, and that it shortens labour. These results suggest that labor induction at 40-40+6 weeks was feasible for low-risk primiparas.Trial registration: The research has been approved by the Ethics Committee of West China Second Hospital of Sichuan University and Chengdu Women and Children's Central Hospital, China. Patients gave written informed consent for their anonymized medical data to be analyzed and published for research purposes.
Subacute Thyroiditis Presenting as Fever of Unknown Origin
Authors: Khalil Abir Bou , Alam Walid , Bizri Abdul Rahman 
Published: December 2020

Abstract
Background: Subacute thyroiditis (SAT) is a rare but well-established cause of fever of unknown origin (FUO) and should be considered in the differential of patients presenting with fever of unknown origin. Few reports in the English literature where published about Subacute thyroiditis manifesting as fever of unknown origin. Subacute thyroiditis may be hard to detect by physicians based on history and physical exam if the systemic manifestations are absent. Methods: An observational retrospective review of 375 charts of patients presenting with thyroiditis to the American University of Beirut Medical Center between January 1995 and June 2015. Inclusion criteria included patients who have subacute thyroiditis based on the American Thyroid Association and American Association of Clinical Endocrinologists guidelines and fever of unknown origin based on Durak and Street’s definition. All patients that do not fit both inclusion criteria were excluded. The patients’ demographics, clinical presentation, laboratory and diagnostic findings, and treatments used were analyzed. Results: 375 charts were reviewed. 31 patients had SAT of which 13 patients had fever of unknown origin before diagnosing subacute thyroiditis. 13 charts were not available for screening. Symptoms of hyperthyroidism including palpitations, neck tenderness and weight loss were not present in all patients. Elevated markers of inflammation mainly ESR and CRP were raised when screened for.Conclusions: The diagnosis of subacute thyroiditis should be considered in patients presenting with fever of unknown origin and elevated inflammatory markers, even in the absence of suggestive clinical symptoms.
Methicillin and Vancomycin Resistant Staphylococcus aureus and Associated Factors from Surgical Ward Inpatients at Debre Markos Referral Hospital, Northwest Ethiopia
Authors: Demsie Samrawit Tefera , Awoke Tewachew , Mekonnen Daniel 
Published: December 2020

Abstract
Background: Staphylococcus aureus is one of the leading wound infections. It is considered as a super bug. The epidemiology of Methicillin Resistant S. aureus (MRSA) and Vancomycin Resistant S. aureus (VRSA) is not well studied in Ethiopia particularly in Debre Markos Referral Hospital (DMRH). The objective of the study was to determine the prevalence of MRSA and VRSA and associated factors from wound cases admitted to surgical ward in DMRH, Northwest Ethiopia.Methods: A cross-sectional study was conducted from February-April 2020 at DMRH. A structured questionnaire was used to collect demographic and clinical characteristics. Wound swabs were collected using sterile cotton swab followed by culturing on Blood agar and Mannitol Salt agar. Then isolates were characterized by gram stain and biochemical tests. The presence of MRSA and VRSA was determined using the cefoxitin (30μg) antibiotic disc diffusion and vancomycin E-test, respectively. The data was analyzed using Statistical Package for Social Sciences, version 20 software. P-value <0.05 was considered statistically significant.Results: A total of 242 wound cases were enrolled and a majority of them were males (172, 71.1%). Among the total wound cases, the isolation rate of S. aureus was 29.3%. The proportion of MRSA was 13.22% and that of VRSA was 4.1%. The proportion of vancomycin intermediate S. aureus (VISA) was gauged at 4.5%. Hospital stay >72h (p=0.014), wound depth (p=0.043), antibiotic use (p=0.017) and previous history of wound infection (p=0.001) showed statistical significant association with MRSA. No variables showed significant association with VRSA.Conclusion: High proportions of S. aureus isolates are resistant to methicillin and vancomycin. Moreover, multiple variables demonstrated associations with drug resistance. Hence, hospital infection control and antibiotic stewardship program shall be strengthened.
α-Synuclein Responses: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease
Authors: Santos Altair B. Dos , Skanning Line K , Mikkelsen Eyd , Romero-Leguizamón Cesar R , Kristensen Morten P , Klein Anders Bue , Langkilde Annette , Kohlmeier Kristi A. 
Published: December 2020

Abstract
Sleep Disorders (SDs) precede motor symptoms of Parkinson’s disease (PD), suggesting an early effect of disease processes on sleep control neurons. PD processes involve rises in the protein, α-synuclein, which presents early on in a simple, monomeric form, but later in disease progression, a more complex fibril form appears. We hypothesize that monomeric α-synuclein has deleterious cellular actions on sleep control nuclei. We monitored cellular responses to identified monomeric and fibril α-synuclein in two sleep controlling nuclei, the laterodorsal tegmentum, and the pedunculopontine tegmentum, as well as the substantia nigra, a motor control nucleus which degenerates as a hallmark PD feature. We monitored differential cell death using a fluorescent-based assay following exposure to the simpler form of α-synuclein. In sleep control nuclei, both forms of intrinsic α-synuclein induced excitation, and increased intracellular calcium and the monomeric form heightened putatively excitotoxic, neuronal death, whereas, in the substantia nigra we saw inhibition, decreased intracellular calcium and monomeric α-synuclein was not associated with heightened cell death. These nucleus-specific differential effects suggest previously unappreciated, mechanistic underpinnings of SDs’ prodromal PD appearance in PD, and we hypothesize that in the prodromal phase of PD, the early form of α-synuclein compromises sleep-control neurons.
Detection and Visualization of Manufacturing Errors of Internal Cavity Structural Parts
Authors: Duan Li-Ming , Si Lei , Luo Xue-Qing , Wu Jia-Hang , Fang Cheng 
Published: December 2020

Abstract
Aiming at the difficulty of manufacturing error detection of internal cavity structural parts, a detection method of common manufacturing error based on industrial CT images was proposed. Firstly, the image sequence of part scanned by an industrial CT machine is converted into a three-dimensional measurement model; Then, the registration of the three-dimensional measurement model with the original design model is completed; The surface information of the part is obtained by segmenting surfaces of the three-dimensional measurement model; Next, the datum surface is selected, the error value of the test surface is calculated after selecting datum surface; Finally, the detection result is obtained by comparing the error value with the tolerance value, analyzing the result and the areas that do not meet the tolerance requirements is visualized in the developed software system. The common manufacturing errors of complex inner cavity parts can be detected by the method, such as dimension error of length, planeness error, cylindricity error, parallelism and perpendicularity error of face-to-face, at the same time, it can intuitively show the area whose manufacturing errors in the cavity structure of the parts are not satisfied, which provides a basis for judging the quality of manufacturing and processing of parts.
Criteria prioritization for sustainable development of second-generation bioethanol in Thailand with an application of Delphi-AHP technique
Authors: Jusakulvijit Piradee , Bezama Alberto , Thrän Daniela 
Published: December 2020

Abstract
Background:

The availability of underexploited agricultural residues in Thailand opens up the opportunity to supply second-generation bioethanol production. The national implementation of residues-to-biofuel can potentially initiate the bioeconomy and greenhouse gas mitigation, requiring engagement from the multi-stakeholders to develop effective policy recommendations. Thus, the study aims to optimize the implementation of the national strategy from a multi-criteria approach to evaluate the concerned aspects and important indicators for second-generation bioethanol development through a participatory prioritization by the actual stakeholders
Methods:

To analyze the relevance of the different dimensions regarding important levels of criteria, a Delphi-AHP technique was applied. The evaluation process was conducted with different stakeholders and elaborated by using a pairwise comparison of 4 dimensions (main-criteria) and 12 indicators (sub-criteria). The evaluation was applied to the participants to share their preferences evaluating the most important factors from the aspect of technical feasibility, environmental impacts, economic feasibility and social impacts.
Results:

Bioethanol stakeholders in Thailand from 5 different branches (industry/ business sectors, NPO/NGO, governmental sectors, academic/research institute and financial institution/bank) participated in the Delphi survey. The 20 expert’s evaluation of four dimensions reveals the highest score from the economic feasibility (32.3%), followed by environmental impacts (25.6%), technical feasibility (24.0%) and social impacts (18.1%). From the sub-criteria assessment, the participants selected ‘final price per liter’, ‘added value of input materials’ and ‘net energy balance’ for the top three important indicators among 12 sub-criteria. From the identification of connection between preferable criteria and participants’ expertise, the results encouraged the process of employing different associated backgrounds into account at the step of policy planning in addition to the consideration of affiliations.
Conclusions:

The stakeholder’s participatory evaluation indicated the importance of economic aspects, highlighting the necessity of the governmental driven policy that needs to be considered. However, implementation scenarios have to be embedded in a broader range of aspects because all the dimension were rated with high impacts. For the future sustainable bioenergy, involvement from stakeholders’ opinions can imply multifaceted scenarios that may interconnect to the social acceptance and benefits for all relevant players when considering the development of advanced bioenergy as a policy recommendation.