bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the ω-multiple Meixner polynomials of the first kind
Authors: Zorlu Oğurlu Sonuç , Elidemir İlkay 
Published: June 2020

AbstractIn this study, we introduce a new family of discrete multiple orthogonal polynomials, namely ω-multiple Meixner polynomials of the first kind, where ω is a positive real number. Some structural properties of this family, such as the raising operator, Rodrigue’s type formula and an explicit representation are derived. The generating function for ω-multiple Meixner polynomials of the first kind is obtained and by use of this generating function we find several consequences for these polynomials. One of them is a lowering operator which will be helpful for obtaining a difference equation. We give the proof of the lowering operator by use of new technique which is a more elementary proof than the proof of Lee in (J. Approx. Theory 150:132–152, 2008). By combining the lowering operator with the raising operator we obtain the difference equation which has the ω-multiple Meixner polynomials of the first kind as a solution. As a corollary we give a third order difference equation for the ω-multiple Meixner polynomials of the first kind. Also it is shown that, for the special case $\omega = 1$ω=1, the obtained results coincide with the existing results for multiple Meixner polynomials of the first kind. In the last section as an illustrative example we consider the special case when $\omega =1/2$ω=1/2 and, for the $1/2$1/2-multiple Meixner polynomials of the first kind, we state the corresponding result for the main theorems.
Trajectory tracking control with preview action for a class of continuous-time Lur’e-type nonlinear systems
Authors: Yu Xiao , Li Li 
Published: June 2020

AbstractA novel preview control scheme is developed for the trajectory tracking problem of continuous-time Lur’e-type nonlinear systems. With the aid of the translation approach, the state augmentation technique along with some special mathematical manipulations, an augmented error system including preview information is constructed. The tracking control problem is thereby reduced to a standard $H_{\infty }$

H
∞

controller design problem. Meanwhile, the integrator is introduced to eliminate the steady-state tracking error. The controller design condition is established in terms of a linear matrix inequality (LMI). As for the original system, the tracking controller is a state feedback controller with tracking error integral plus preview action. Finally, an example is given to illustrate the tracking performance of the proposed method.
Existence results of nonlocal Robin mixed Hahn and q-difference boundary value problems
Authors: Dumrongpokaphan Thongchai , Patanarapeelert Nichaphat , Sitthiwirattham Thanin 
Published: June 2020

AbstractIn this paper, we aim to study a nonlocal Robin boundary value problem for fractional sequential fractional Hahn-q-equation. The existence and uniqueness results for this problem are revealed by using the Banach fixed point theorem. In addition, the existence of at least one solution is studied by using Schauder’s fixed point theorem. The theorems for existence results are obtained.
Image data model optimization method based on cloud computing
Authors: Liu Jingyu , Wu Jing , Sun Linan , Zhu Hailong 
Published: June 2020

AbstractIn the current age of data explosion, the amount of data has reached incredible proportions. Digital image data constitute most of these data. With the development of science and technology, the demand for networked work and life continues to grow. Cloud computing technology plays an increasingly important role in life and work. This paper studies the optimization methods for cloud computing image data recognition models. The parallelization and task scheduling of the remote-sensing image classification model SCSRC based on spatial correlation regularization and sparse representation are studied in a cloud computing platform. First, cloud detection technology, combined with the dynamic features of the edge overlap region, is implemented in cloud computing mode. For image edge overlap region detection, the SCSRC method is implemented on a single machine, and the time performance of the method is analysed experimentally, which provides a basis for parallelization research under the cloud computing platform. Finally, the speedup and expansion ratio of the SK-SCSRC algorithm are determined by experiment, and MR-SCSRC and SK-SCSRC are compared. The simulation results show that, compared to previous methods, the method of image edge overlap detection is more accurate and the image fusion is better, which improves the image recognition ability in the overlap region and demonstrates the performance improvement of the MR-SCSRC algorithm under scheduling. This method addresses the shortcomings of Hadoop’s existing scheduler and can be integrated into remote-sensing cloud computing systems in the future.
Innovative use of data sources: a cross-sectional study of data linkage and artificial intelligence practices across European countries
Authors: Haneef Romana , Delnord Marie , Vernay Michel , Bauchet Emmanuelle , Gaidelyte Rita , Van Oyen Herman , Or Zeynep , Pérez-Gómez Beatriz , Palmieri Luigi , Achterberg Peter , Tijhuis Mariken , Zaletel Metka , Mathis-Edenhofer Stefan , Májek Ondřej , Haaheim Håkon , Tolonen Hanna , Gallay Anne 
Published: June 2020

AbstractBackgroundThe availability of data generated from different sources is increasing with the possibility to link these data sources with each other. However, linked administrative data can be complex to use and may require advanced expertise and skills in statistical analysis. The main objectives of this study were to describe the current use of data linkage at the individual level and artificial intelligence (AI) in routine public health activities, to identify the related estimated health indicators (i.e., outcome and intervention indicators) and health determinants of non-communicable diseases and the obstacles to linking different data sources.MethodWe performed a survey across European countries to explore the current practices applied by national institutes of public health, health information and statistics for innovative use of data sources (i.e., the use of data linkage and/or AI).ResultsThe use of data linkage and AI at national institutes of public health, health information and statistics in Europe varies. The majority of European countries use data linkage in routine by applying a deterministic method or a combination of two types of linkages (i.e., deterministic & probabilistic) for public health surveillance and research purposes. The use of AI to estimate health indicators is not frequent at national institutes of public health, health information and statistics. Using linked data, 46 health outcome indicators, 34 health determinants and 23 health intervention indicators were estimated in routine. The complex data regulation laws, lack of human resources, skills and problems with data governance, were reported by European countries as obstacles to routine data linkage for public health surveillance and research.ConclusionsOur results highlight that the majority of European countries have integrated data linkage in their routine public health activities but only a few use AI. A sustainable national health information system and a robust data governance framework allowing to link different data sources are essential to support evidence-informed health policy development. Building analytical capacity and raising awareness of the added value of data linkage in national institutes is necessary for improving the use of linked data in order to improve the quality of public health surveillance and monitoring activities.
Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: results of a multicenter randomized placebo-controlled clinical trial
Authors: Mulder Tessa , Kluytmans-van den Bergh Marjolein , Vlaminckx Bart , Roos Daphne , de Smet Anne Marie , de Vos tot Nederveen Cappel Robert , Verheijen Paul , Brandt Alexandra , Smits Anke , van der Vorm Eric , Bathoorn Erik , van Etten Boudewijn , Veenemans Jacobien , Weersink Annemarie , Vos Margreet , van ’t Veer Nils , Nikolakopoulos Stavros , Bonten Marc , Kluytmans Jan 
Published: June 2020

Abstract
Background
Surgical site infections (SSIs) are common complications after colorectal surgery. Oral non-absorbable antibiotic prophylaxis (OAP) can be administered preoperatively to reduce the risk of SSIs. Its efficacy without simultaneous mechanical cleaning is unknown.

Methods
The Precaution trial was a double-blind, placebo-controlled randomized clinical trial conducted in six Dutch hospitals. Adult patients who underwent elective colorectal surgery were randomized to receive either a three-day course of preoperative OAP with tobramycin and colistin or placebo. The primary composite endpoint was the incidence of deep SSI or mortality within 30 days after surgery. Secondary endpoints included both infectious and non-infectious complications at 30 days and six months after surgery.

Results
The study was prematurely ended due to the loss of clinical equipoise. At that time, 39 patients had been randomized to active OAP and 39 to placebo, which reflected 8.1% of the initially pursued sample size. Nine (11.5%) patients developed the primary outcome, of whom four had been randomized to OAP (4/39; 10.3%) and five to placebo (5/39; 12.8%). This corresponds to a risk ratio in the intention-to-treat analysis of 0.80 (95% confidence interval (CI) 0.23–2.78). In the per-protocol analysis, the relative risk was 0.64 (95% CI 0.12–3.46).

Conclusions
Observational data emerging during the study provided new evidence for the effectiveness of OAP that changed both the clinical and medical ethical landscape for infection prevention in colorectal surgery. We therefore consider it unethical to continue randomizing patients to placebo. We recommend the implementation of OAP in clinical practice and continuing monitoring of infection rates and antibiotic susceptibilities.

Trial registration
The PreCaution trial is registered in the Netherlands Trial Register under NL5932 (previously: NTR6113) as well as in the EudraCT register under 2015–005736-17.
RDGN-based predictive model for the prognosis of breast cancer
Authors: Dong Bing , Yi Ming , Luo Suxia , Li Anping , Wu Kongming 
Published: June 2020

Abstract
Background
Breast cancer is the most diagnosed malignancy in females in the United States. The members of retinal determination gene network (RDGN) including DACH, EYA, as well as SIX families participate in the proliferation, apoptosis, and metastasis of multiple tumors including breast cancer. A comprehensive predictive model of RDGN might be helpful to herald the prognosis of breast cancer patients.

Methods
In this study, the Gene Expression Ominibus (GEO) and Gene Set Expression Analysis (GSEA) algorithm were used to investigate the effect of RDGN members on downstream signaling pathways. Besides, based on The Cancer Genome Atlas (TCGA) database, we explored the expression patterns of RDGN members in tumors, normal tissues, and different breast cancer subtypes. Moreover, we estimated the relationship between RDGN members and the outcomes of breast cancer patients. Lastly, we constructed a RDGN-based predictive model by Cox proportional hazard regression and verified the model in two separate GEO datasets.

Results
The results of GSEA showed that the expression of DACH1 was negatively correlated with cell cycle and DNA replication pathways. On the contrary, the levels of EYA2 and SIX1 were significantly positively correlated with DNA replication, mTOR, and Wnt pathways. Further investigation in TCGA database indicated that DACH1 expression was lower in breast cancers especially basal-like subtype. In the meanwhile, SIX1 was remarkably upregulated in breast cancers while EYA2 level was increased in Basal-like and Her-2 enriched subtypes. Survival analyses demonstrated that DACH1 was a favorable factor while EYA2 and SIX1 were risk factors for breast cancer patients. Given the results of Cox proportional hazard regression analysis, two members of RDGN were involved in the present predictive model and patients with high model index had poorer outcomes.

Conclusion
This study showed that aberrant RDGN expression was an unfavorable factor for breast cancer. This RDGN-based comprehensively framework was meaningful for predicting the prognosis of breast cancer patients.
Evaluation of morbidity in Schistosoma mansoni-positive primary and secondary school children after four years of mass drug administration of praziquantel in western Kenya
Authors: Abudho Bernard O. , Guyah Bernard , Ondigo Bartholomew N. , Ndombi Eric M. , Ireri Edmund , Carter Jennifer M. , Riner Diana K. , Kittur Nupur , Karanja Diana M. S. , Colley Daniel G. 
Published: June 2020

Abstract
Background
World Health Organization guidelines recommend preventive chemotherapy with praziquantel to control morbidity due to schistosomiasis. The primary aim of this cross-sectional study was to determine if 4 years of annual mass drug administration (MDA) in primary and secondary schools lowered potential markers of morbidity in infected children 1 year after the final MDA compared to infected children prior to initial MDA intervention.

Methods
Between 2012 and 2016 all students in two primary and three secondary schools within three kilometers of Lake Victoria in western Kenya received annual mass praziquantel administration. To evaluate potential changes in morbidity we measured height, weight, mid-upper arm circumference, hemoglobin levels, abdominal ultrasound, and quality of life in children in these schools. This study compared two cross-sectional samples of Schistosoma mansoni egg-positive children: one at baseline and one at year five, 1 year after the fourth annual MDA. Data were analyzed for all ages (6–18 years old) and stratified by primary (6–12 years old) and secondary (12–18 years old) school groups.

Results
The prevalence of multiple potential morbidity markers did not differ significantly between the egg-positive participants at baseline and those at 5 years by Mann Whitney nonparametric analysis and Fisher’s exact test for continuous and categorical data, respectively. There was a small but significantly higher score in school-related quality of life assessment by year five compared to baseline by Mann Whitney analysis (P = 0.048) in 13–18 year olds where malaria-negative. However, anemia was not positively impacted by four annual rounds of MDA, but registered a significant negative outcome.

Conclusions
We did not detect differences in morbidity markers measured in a population of those infected or re-infected after multiple MDA. This could have been due to their relative insensitivity or a failure of MDA to prevent morbidity among those who remain infected. High malaria transmission in this area and/or a lack of suitable methods to measure the more subtle functional morbidities caused by schistosomiasis could be a factor. Further research is needed to identify and develop well-defined, easily quantifiable S. mansoni morbidity markers for this age group.
Soil releasing as key to rethink water spaces in urban planning
Authors: Adobati Fulvio , Garda Emanuele 
Published: June 2020

AbstractSoil sealing processes that involved European cities in the twentieth century have reduced the quantity and quality of permeable soils (open land for agricultural and leisure resources). These processes have also weakened the ability of urban areas to manage natural events, of all evidence regarding the water cycle. This intense phase was supported by a cycle of growth that showed signs of an irreversible crisis only in the last decade, starting a new and unprecedented season. However, soil sealing development constitutes the most intense form of land degradation and affects all ecosystem services (Tobias et al. in Land Degrad 29:2015–2024, 2018). This is particularly true for spaces and territories along main rivers where the presence of sealed areas and concrete channels (riverbed and riverbanks) represents a problem regarding hydrogeological, ecological, and landscaping aspects. To safeguard urban systems, by restoring “landscape river” (and its surroundings), increasing green areas and more efficient management of the rainwater, it is fundamental to enhance the “removing sealing layers” (EU 2012) according to a holistic approach. This paper explores the de-sealing concept and highlights some international and Italian cases, in particular the River Contracts experience promoted in the Lombardy Region, including actions proposed by public policies and urban planning tools. All these experiences have proposed de-sealing processes of river environments and urban systems ensuring a new integration between urban areas and “water landscapes”. To underline some characteristics this exploration allowed: to highlight different de-sealing approaches, between direct or indirect conditioning; to recognize river elements and “environments” in which these initiatives are activated; to recognize in these initiatives a multi-scale attitude both the expected effects and the type of involved institutional subject involved; to identify the main subjects, with specific roles and responsibilities, in this type of process; to recognize limits and critical issues. River restoration, combined with de-sealing actions inside the urban structures, shall be performed by answering to several needs: increasing the green open space quantity and ecosystem services recovery; contributing to biodiversity by restoring ecosystems and ecological processes; balancing the soil-sealing negative externalities; improving the flood-risk mitigation and management in urban areas. In particular, the voluntary instrument of the River Contract includes a territorial area that is adequate for the treatment of the phenomenon but is struggling to be codified in the local planning instruments with cogency. The assumption of different spaces and the recognition of the same in the spatial devices of urban planning instruments could define more clearly the need to face the water-city relationship effectively, for the benefit of urban security and the quality of the inhabitants’ living environment.
How do the digital competences of students in vocational schools differ from those of students in cooperative higher education institutions in Germany?
Authors: Wild Steffen , Schulze Heuling Lydia 
Published: June 2020

AbstractDigital skills are thought to be a key competence of the twenty-first century. With the rapid growth of internet and communication tool (ICT) usage among both students and teachers, cooperative (co-op) education programmes, like other educational institutions, face the challenge of integrating and supporting digital skill development. However, little is known about how these skills are developed prior to entering cooperative education programmes. Against this background, a sample of 893 freshers, ranging from vocational students to co-op students, were tested according to their digital skills. The analysis shows that co-op students have a higher level of competence than vocational students. In addition, we found that in our sample social background has no impact on digital competences. The results are discussed and classified in the context of the current state of research.
Variations of rhizospheric soil microbial communities in response to continuous Andrographis paniculata cropping practices
Authors: Li Junren , Chen Xiuzhen , Li Simin , Zuo Zimei , Zhan Ruoting , He Rui 
Published: June 2020

Abstract
Background
Changes of soil microbial communities are one of the main factors of continuous cropping problem. Andrographis paniculata has been reported to have replant problem in cultivation. However, little is known about the variations of rhizosphere soil microbial communities of A. paniculata under a continuous cropping system. Here, Illumina MiSeq was used to investigate the shifts of rhizospheric bacterial and fungal communities after continuous cropping of A. paniculata.

Results
The bacterial diversity increased whereas the fungal diversity decreased in rhizosphere soil after consecutive A. paniculata monoculture; and the soil microbial community structure differed between newly plant soil and continuous cropped soil. Taxonomic analyses further revealed that the bacterial phyla Proteobacteria, Acidobacteria and Bacteroidetes and the fungal phyla Zygomycota, Ascomycota and Cercozoa were the dominant phyla across all soil samples. The relative abundance of phyla Acidobacteria and Zygomycota were significantly increased after continuous cropping. Additionally, the most abundant bacterial genus Pseudolabrys significantly decreased, while the predominant fungal genus Mortierella increased considerably in abundance after continuous cropping.

Conclusions
Our results revealed the changes on diversity and composition of bacterial and fungal communities in rhizospheric soil under continuous cropping of A. paniculata. These data contributed to the understanding of soil micro-ecological environments in the rhizosphere of A. paniculata.
Save the ICU and save lives during the COVID-19 pandemic
Authors:   Japan ECMOnet for COVID-19, Abe Ryuzo , Bunya Naofumi , Endo Tomoyuki , Fujino Yuji , Fujita Kensuke , Fujizuka Kenji , Hagiwara Yoshihiro , Hamaguchi Jun , Hara Yoshitaka , Hashiba Eiji , Hashimoto Satoru , Hattori Noriyuki , Hoshino Kota , Ijuin Shinichi , Ikeyama Takanari , Ichiba Shingo , Iwanaga Wataru , Iwashita Yoshiaki , Kanamoto Masafumi , Kaneko Hitoshi , Kawamae Kaneyuki , Kotani Toru , Koyama Yasuaki , Liu Keibun , Masuno Tomohiko , Morimura Naoto , Nakamura Tomoyuki , Nakane Masaki , Nasu Michitaka , Nishida Osamu , Nishimura Masaji , Ochiai Kanae , Ogura Takayuki , Ohshimo Shinichiro , Oyama Keisuke , Sasaki Junichi , Seo Ryutaro , Shimazu Takeshi , Shime Nobuaki , Shimizu Keiki , Suzuki Hiroyuki , Takauji Shuhei , Takeda Shinhiro , Takeuchi Ichiro , Takita Mumon , Taniguchi Hayato , Shime Nobuaki 
Published: June 2020

AbstractAppropriate critical care delivery for Coronavirus disease 2019 (COVID-19) is a cornerstone in saving lives. Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical ventilation in intensive care units during “surges” in the number of cases. In contrast, lower mortality outcomes are evident in Japan using CRISIS [CRoss Icu Searchable Information System] data by the national registry, Japan ECMOnet for COVID-19. This highlights the need for scientific analysis of the medical factors contributing to high survival rates and social factors associated with low case “surges,” to gain insight into protective strategies for possible coming waves in the COVID-19 pandemic.