bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fermented Soy Beverage Q-CAN® Plus Induces Beneficial Changes in the Oral and Intestinal Microbiome
Authors: Dioletis Evangelos , Paiva Ricardo , Kaffe Eleanna , Secor Eric R. , Weiss Theresa R. , Fields Maxine R. , Ouyang Xinshou , Ali Ather 
Published: April 2020

Abstract
Background
Q-CAN® Plus is a pasteurized soy fermented product rich in isoflavones that has been used for over 30 years to aid in recovery from a wide range of conditions.
Objectives
To identify the changes in the oral and fecal microbiome in lean and obese subjects due to consumption of Q-CAN®, and to assess the expected consequences of these changes based on the published literature.
Methods
Prospective study of lean (10) and obese (9) subjects consuming Q-CAN® twice daily for 4 weeks with 8 weeks follow-up. Microbial DNA was extracted from saliva and stool samples, amplified against the V4 region of the 16S ribosomal RNA gene and data analyzed using QIIME 1.9.1 bioinformatics. 440 samples were collected in total, 424 of which were productive and yielded good quality data.
Results
STOOL. In the lean population Bifidobacteria and Blautia show a significant increase while taking Q-CAN®, and there was a trend for this in the obese population. ORAL. There were relatively fewer major changes in the oral microbiome with an increase in the family Veillonellaceae in the lean population while on Q-CAN®.
Conclusion
Q-CAN® consumption induced a number of significant changes in the fecal and oral microbiome. Most notably an increase in the stool microbiome of Bifidobacteria and Blautia, both of which are associated with positive health benefits, and in the saliva an increase in Veillonellaceae.
Biomechanical evaluation of type p condylar head osteosynthesis using conventional small-fragment screws reinforced by a patient specific two-component plate
Authors: Pavlychuk Tetiana , Chernogorskyi Denis , Chepurnyi Yurii , Neff Andreas , Kopchak Andrii 
Published: April 2020

Abstract
Background. The aim of this study was to evaluate via finite element analysis (FEA) the biomechanical behavior of conventional small-fragment screws reinforced by a patient-specific plate in type p condylar head.Methods. A finite element model of the mandible was created using Mimics 12.1 software. A type p condylar head fracture was simulated in the right condyle, and the left condyle was used as a control. Two patterns of fixation were investigated: conventional two-screw fixation and the same fixation system reinforced with a small, patient-specific plate. Surface models were imported into the software Ansys 5.7 for further volume mesh generation.Results. The highest stress gradients were observed in the cortical layer of the lateral fragment, located near the screw. The conventional fixation method resulted in equivalent stresses 2 to 10 times greater than the reinforced method. Rigidity of fixation in the reinforced method increased up to 1.25–3 times compared to the conventional two-screw technique.Conclusion. This study’s findings suggest significant benefits in unfavourable biomechanical conditions from reinforcement of the standard two-screw fixation of condylar head fractures with a small, patient-specific plate acting as a washer.
Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: A retrospective study
Authors: Kondo Masahiro , Hotta Yuji , Yamauchi Karen , Sanagawa Akimasa , Komatsu Hirokazu , Iida Shinsuke , Kimura Kazunori 
Published: April 2020

Abstract
Background
Many novel medicines such as proteasome inhibitors have been developed during the last decade to treat multiple myeloma. Although multiple myeloma is defined as a low-risk disease for developing tumor lysis syndrome (TLS), treatment with these novel therapies might increase TLS risk. In fact, there have been some prior reports of bortezomib-induced TLS in patients with multiple myeloma. However, almost all of them have been case reports or case series. Thus, we investigated the risk factors for TLS in multiple myeloma patients.
Methods
We retrospectively investigated incidences of laboratory and clinical TLS (LTLS and CTLS, respectively) in patients who received primary therapy for treatment-naive, symptomatic multiple myeloma between May 2007 and January 2018. We used multivariate logistic regression analyses to evaluate the associations between LTLS and several parameters previously reported to be associated with increased risk.
Results
This study included 210 patients, seventeen (8.1%) and seven (3.3%) patients with LTLS and CTLS, respectively. The characteristics of the administered anticancer or prophylactic antihyperuricemic agents were similar between the patients with and without LTLS. Multivariate analyses revealed that LTLS was most strongly associated with bortezomib-containing therapy (odds ratio = 3.40, P = 0.069), followed by male sex (odds ratio = 2.29, P = 0.153). In a subgroup analysis focused on men, treatment with bortezomib-containing therapy was significantly associated with increased risk of LTLS (odds ratio = 8.51, P = 0.046).
Conclusion
In the present study, we investigated the risk factors for developing TLS in 210 multiple myeloma patients, which, to the best of our knowledge, is the largest number of patients reported to date. Furthermore, this study is the first to evaluate TLS risk factors in MM by adjusting for the effects of potential confounding factors in patients’ backgrounds. Consequently, we found that bortezomib-containing therapy increases the risk of TLS in male multiple myeloma patients. TLS risk should be evaluated further in low-risk diseases such as multiple myeloma, as an increasing number of novel therapies can achieve high antitumor responses.
Simulation Training Program of Pediatric Appropriate Technology Improves Knowledge for doctors and nurses in Zanzibar: A Quasi-experimental Study
Authors: WANG Li , SONG Qing-qing , ZHU Li-hui , DING Xiang , QIU Jun , LIU Shi-ying , WEI Xuan-dong , LIANG You-you 
Published: April 2020

Abstract
Background: Due to the limited human resource and medical materials, the mortality of children under-5 was high in Tanzania. Systematic and effective training programs for pediatric medical staffs are required. Thus, aim of this study was to describe and test a simulation training program of pediatric technology for doctors and nurses in Zanzibar.Methods: A simulation training program of pediatric appropriated technology was designed and performed in this quasi-experimental study, in which pre-post self-reported of pediatric knowledge (scoring 0-100) of participants were calculated to analysis the effectiveness of this simulation training in Apr, 2018 and Oct, 2018. Correctly answering of items≥80% was considered to be a pass. Data were entered and analyzed in SPSS 22.0 software to test the hypothesis. Results: 56 participants were finally included in this study with 27 doctors and 29nurses. Pre and post test scores of pediatric knowledge were at mean 44.32 (SD 9.53) versus mean 82.11 (SD 11.06) respectively, p<0.0001. The most effective training domain was (pediatric life support) at 44(78.57). Passing rate of pediatric knowledge increased dramatically after training with p value less than 0.0001. Although there was a mild difference between doctors and nurses at scoring of pre-test (p=0.048), the training effect between them had no statistical differences (p>0.05).Conclusion: The scenario simulation training course of pediatric appropriated technology could significantly improve pediatric knowledge for doctors and nurses in Zanzibar. It might be further promoted as one effective module of training in health foreign aid.
Does the Expensive IOFix implant Improve Union Rates?
Authors: Segal David , Ohana Nissim , Nyska Meir , Palmanovich Ezequiel 
Published: April 2020

Abstract
BACKGROUND
First metatarso-phalangeal joint fusion is the current gold standard for severe hallux rigidus. Data regarding the union rate and the re-operation rate when IOFix (an Intra-osseous fixation device, Extremity medical, New Jersey, USA) is used for hallux rigidus fusion is limited but promising. The aim of this study was to review our outcomes with the IOFix implant.
METHODS
We have conducted a retrospective chart review, following the approval of the hospital IRB committee. Exclusion criteria included bilateral operations on the same patient, multiple surgeries, charcot foot or other structural foot abnormalities (except hallux valgus), rheumatoid arthritis and a recent foot trauma. We collected demographic data, physical examination documentation, functional score evaluations (AOFAS), and X-ray radiographic studies.
RESULTS
Thirty patients were included in the study. The mean age was 60.36 ± 9.12 (range 36 to 77) years, 18 (60%) female patients and 12 (40%) male. Fourteen (53.33%) were left side pathologies. The average follow up period was 36.2 ± 12.31 (range 12 to 54) months. Union was obtained in 28 (93.33%) patients, of whom none had requested a hardware removal due to a prominent hardware during a minimum of 2 year follow up period. The mean postoperative AOFAS score was 80.5 ± 10.87 (range 35 to 90). A more stringent inclusion criteria and fusion definitions would have led to an exclusion of two more patients and a dropout of two patients from the “fused” group, which would have led to a fusion rate of 85.71%.
CONCLUSIONS
This is the largest series of hallux rigidus patients that were operated with an IOFix device. The rates of fusion and hardware removal in MTPJ1 arthrodesis performed with an IOFix implant were found to be similar at most when compared to previously described rates that were obtained with other cheaper and more simple fixation devices.
Prediction of Volume Responsiveness by Stroke Volume Variation vs. Central Venous Pressure in Children Undergoing Fontan Operation
Authors: Song Yun'an , Hou Huiyan , Bai Jie , Gu Hongbin 
Published: April 2020

Abstract
Background: Fontan operation is a palliative medical procedure performed on children with single-ventricle defects. As postoperative success of the procedure largely depends on the preload volume, it is necessary to ensure the effective volume of systemic circulation by maintaining an appropriate pressure gradient between the systemic vein and the left atrium. However, there is a lack of effective indexes to evaluate volume responsiveness in Fontan patients. Stroke volume variation (SVV) is a dynamic hemodynamic parameter based on cardiopulmonary interaction in mechanical ventilation. This study is to validate the sensitivity and specificity of SVV vs. central venous pressure (CVP) in assessing volume responsiveness of Fontan patients.Method: 64 children were included in this prospective study with single-ventricle who underwent modified Fontan operation between May 2018 and January 2020. Patients were given 10ml·kg− 1 albumin for volume challenge within 10 min after CPB. Before and after volume challenge, the invasive arterial pressure module was connected to Mostcare™ equipment to collect SBP, MBP, DBP, SVV, CI and SVRI dynamically in a time window of 30 s at a frequency of 1000 Hz. According to the range of CI change, patients with ΔCI ≥ 15% were classified into response (R) group and patients with ΔCI < 15% into non-response (NR) group. Using SVV and CVP as indicators, the ROC of the patients was established, and the AUC, diagnostic threshold, sensitivity and specificity were calculated.Results: The 64 pediatric patients included with a mean age of 4.85 ± 1.20 years, a mean height of 98.00 ± 16.74 cm and a mean weight of 15.65 ± 5.37 kg. The SVV value was 17.15 ± 3.97% and 13.45 ± 2.45% before and after fluid challenge treatment vs. 18.60 ± 1.83 mmHg and 20.20 ± 2.39 mmHg for CVP in responders. The AUC of SVV was 0.74 (95% confidence interval [CI] 0.54–0.94, P < 0.05) and the cutoff value was 16%, offering a sensitivity of 50% and a specificity of 91.7% vs.0.70 (95% CI 0.50–0.92, P > 0.05), 19.5 mmHg, 58% and 76% for CVP.Conclusion: SVV exhibited a good predictive value for volume responsiveness in pediatric Fontan patients. Appropriate volume therapy according to SVV could improve the cardiac function of such patients.Trial registration: This research was registered in Chinese Clinical Trail Registry on Jan 26, 2018. Registration number is ChiCTR1800014654.Registry URL is http://www.chictr.org.cn/showproj.aspx?proj=25019. This observational prospective study was approved by the Local Ethics Committee of Shanghai Children’s Medical Center affiliated to Shanghai Jiao Tong University (SCMCIRB-K2017035)
Development and Initial Validation of a Scale for Assessing Affecting Factors on Preventive Behaviors of COVID-19 (AFPB-CO): Using the Protection Motivation Theory
Authors: Khazaee-Pool Maryam , Naghibi Seyed Abolhassan , Pashaei Tahereh , Jahangiry Leila , Daneshnia Mahbobeh , Ponnet Koen 
Published: April 2020

Abstract
Background

The protection motivation theory (PMT) is a practical theory for defining how people are interested in responding in a self-protective way concerning a perceived health threat. At present, there is no comprehensive, validated scale for measuring factors affecting on people’ participation on preventive behaviors about COVID-19 in the world. A current study accomplished to develop and evaluate the validity and reliability of the theory-based scale using the protection motivation theory (PMT) constructs as a theoretical structure for measuring factors affecting on preventive behaviors of COVID-19.
Design and methods:

A multi-phase scale developmental method was applied to develop a scale for assessing affecting factors on preventive behaviors about COVID-19 (AFPB-CO) in 2020. The items for the AFPB-CO scale were made using three methods: literature review, interview with laypeople, and expert panel. To prepare a draft form of the AFPB-CO scale, we accomplished content and face validity analyses. The AFPB-CO scale validation was accompanied by a sample of laypeople, recruited from cyberspace and social networks. Finally, the construct validity of the AFPB-CO scale was assessed by applying both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Internal consistency and test-retest methods were used for assessing the reliability of the AFPB-CO scale. Data were analyzed using SPSS and AMOS.
Results

Results obtained from factor analysis showed that the data were fit to the model (χ2 = 5276.468, P < 0.001), and MPT consisted of 36 items assessing five domains, which describing 58.64% of the common variance. The CFA showed a model with suitable fitness for the data. Cronbach’s alpha coefficient for the domains of the scale ranged from .62 to .84, and the ICC value ranged from .73 to .87, which is within satisfactory ranges.
Conclusions

The results from this study show that the Iranian version of the AFPB-CO has excellent psychometric properties and is appropriate for assessing the affecting factors on preventive behaviors among Iranian people toward COVID-19.
Design and evaluation of an intelligent physical examination system in improving the satisfaction of patients with chronic disease
Authors: Chen Xin , Duan Ruxin , Shen Yao , Jiang Hua 
Published: April 2020

Abstract
Background: The doctor-patient relationship is very important for healthcare quality. Improving the patients satisfaction is important for doctor-patient relationship. The relationship between patients with chronic disease and doctors often established in the process of physical examination in outpatient clinics. The use of artificial intelligence (AI) in the Internet of Health Thing (loHT) introduce the possibility of developing an intelligent system in hospital to establish a good doctor-patient relationship through improving the satisfaction of patients. We aimed to establish an intelligent physical examination system and preliminarily investigate its effect on improving the satisfaction of patients with chronic disease. Methods: An intelligent chronic disease management system based on the AI in the internet of health things was established. This system was combined with traditional Chinese medicine and western medicine. A total of 115 patients with chronic disease, who underwent physical examination in our hospital from August, 2019 to November, 2019 were enrolled in this study. Among them, 55 patients were in the intelligent system (intelligent group) and 60 patients were in the traditional system (control group). We collected the satisfaction questionnaire of patients who took physical examination in these two systems. Satisfaction score between intelligent group and control group was compared. Results: A total of 106 patients were finally taken into analyzed . There was no statistical difference in age, gender , education or income level between intelligent group and control group. We found significant differences in the five aspects of satisfaction (1 . the physical examination environment; 2.the attitude and responsiveness of doctors; 3.the attitude and responsiveness of nurses ； 4.the effectiveness of getting results; 5.the information of physical examination and medical advices) (p ＜ 0.05). Moreover, in the logistic regression, the differences were still statistically significant after adjusting age, gender, education and income level. Conclusions: The intelligent physical examination system might be an effective tool in improving the satisfaction of patients with chronic disease. This could play an important role in establishing a good doctor-patient relationship .
Socio-Demographic Characteristics Associated With Emotional and Social Loneliness Among Older Adults in Five European Countries
Authors: Fierloos Irene Noëlla , Tan Siok Swan , Williams Greg , Alhambra-Borrás Tamara , Koppelaar Elin , Bilajac Lovorka , Verma Arpana , Markaki Athina , Raso Francesco Mattace , Vasiljev Vanja , Franse Carmen Betsy , Raat Hein 
Published: April 2020

Abstract
Background International studies provide an overview of socio-demographic characteristics associated with loneliness among older adults, but few studies distinguished between emotional and social loneliness. This study examined socio-demographic characteristics associated with emotional and social loneliness.Methods Data of 2251 community-dwelling older adults, included at the baseline measure of the Urban Health Centers Europe (UHCE) project, were analysed. Loneliness was measured with the 6-item De Jong-Gierveld Loneliness Scale. Multivariable logistic regression models were used to evaluate associations between age, sex, living situation, educational level, migration background, and loneliness.Results The mean age of participants was 79.7 years (SD = 5.6 years); 60.4% women. Emotional and social loneliness were reported by 29.2% and 26.7% of the participants. Older age (OR: 1.16, 95% CI: 1.06–1.28), living without a partner (2.16, 95% CI: 1.73–2.70), and having a low educational level (OR: 1.82, 95% CI: 1.21–2.73), were associated with increased emotional loneliness. Women living with a partner were more prone to emotional loneliness than men living with a partner (OR: 1.78, 95% CI: 1.31–2.40). Older age (OR: 1.11, 95% CI: 1.00-1.22) and having a low educational level (OR: 1.77, 95% CI: 1.14–2.74) were associated with increased social loneliness. Men living without a partner were more prone to social loneliness than men living with a partner (OR: 1.94, 95% CI: 1.35–2.78).Conclusions Socio-demographic characteristics associated with emotional and social loneliness differed regarding sex and living situation. Researchers, policy makers, and healthcare professionals should be aware that emotional and social loneliness may affect older adults with different socio-demographic characteristics.
The impact of equity factors on receipt of timely appropriate care for children with suspected malaria in eastern Uganda
Authors: Humphreys David , Kalyango Joan Nakayaga , Alfven Tobias 
Published: April 2020

Abstract
IntroductionMalaria accounts for more than one-tenth of sub-Saharan Africa’s 2.8 million annual childhood deaths, and remains a leading cause of post-neonatal child mortality in Uganda. Despite increased community-based treatment in Uganda, children continue to die because services fail to reach those most at risk. This study explores the influence of two key equity factors, socioeconomic position and rurality, on whether children with fever in eastern Uganda receive timely access to appropriate treatment for suspected malaria.MethodsData were collected from 1,094 caregivers of children aged 6-59 months on: illness and care-seeking during the previous two weeks, treatment received, and treatment dosing schedule. Additional data on rurality and household socioeconomic position were extracted from the Iganga-Mayuge Health and Demographic Surveillance Site (HDSS) database. A child was considered to have received prompt and appropriate care for symptoms of malaria if they received the recommended drug in the recommended dosing schedule on the day of symptom onset or the next day. Unadjusted and adjusted logistic regression models were developed to explore associations of the two equity factors with the outcome.ResultsSeventy-four percent of children had symptoms of illness in the preceding two weeks, of which fever was the most common. Children from rural households were statistically more likely to receive prompt and appropriate treatment with artemisinin-combination therapy than their semi-urban counterparts (OR 2.32, CI 1.17-4.59, p=0.016). This association remained significant following application of an adjusted regression model that included the age of the child, caregiver relationship, and household wealth index (OR 2.4, p = 0.036). Wealth index in its own right did not exert a significant effect for children with reported fever (OR for wealthiest quintile = 1.02, CI 0.48-2.15, p=0.958).ConclusionsThe findings from this study help to identify the role and importance of two key equity determinants on care seeking and treatment receipt for fever in children. Whilst results should be interpreted within the limitations of data and context, further studies have the potential to assist policy makers to target inequitable social and spatial variations in health outcomes as a key strategy in ending preventable child morbidity and mortality.
Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression
Authors: Liu Shudong , Li Wenyan , Yang Ling , Shi Hui , Zhang Jiangwei , yang zhao 
Published: April 2020

Abstract
Introduction: TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transduced with TIPE-2 has not been well studied. Methods: In this study, DCs were transduced with TIPE-2 recombinant adenovirus, and then were cocultured with allogeneic CD4 + or CD8 + T cells. The proliferation, cytokine production and activation marker levels of CD4 + or CD8 + T cell were detected. Results: The data demonstrated that T cell proliferation, cytokine production and activation marker levels were attenuated after treated with TIPE-2 transduced DCs. Conclusions: These results suggested that TIPE-2 transduced DCs are capable of inducing allogeneic CD4 + or CD8 + T cell immune suppression, which provide a promising way for the therapeutical strategies of transplantation or autoimmune diseases.