bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Myofascial Release Intervention and Mobile App in Patients With Hemophilic Ankle Arthropathy: Protocol for a Randomized Controlled Trial
Authors: Meroño-Gallut Antonio Javier , Cuesta-Barriuso Rubén , Pérez-Llanes Raúl , Donoso-Úbeda Elena , López-Pina José-Antonio 
Published: April 2020

Background
Hemophilic ankle arthropathy is manifested by degenerative functional alterations and chronic pain. Myofascial release techniques are used to treat soft tissue adhesions, relieve pain, and reduce tissue sensitivity.

Objective
This study aims to evaluate the safety and efficacy of a protocol using self-myofascial release with a foam roller to be applied in patients with hemophilic ankle arthropathy.

Methods
Patients with ankle arthropathy (N=70) will be recruited, enrolled, and assigned to one of two groups—experimental or control—in a 1:1 allocation ratio. Patients will be recruited from 5 centers in different regions of Spain. Patient data will be collected at baseline, posttreatment, and follow-up. The primary outcome will be frequency of ankle joint bleeding (self-reported). The secondary outcomes will be ankle range of motion (measured with a digital goniometer); joint pain (measured with a visual analog scale and an algometer); joint status (measured using the Hemophilia Joint Health Score); muscle strength (measured with a dynamometer); functionality of lower limbs (measured using the 6-minute walking test); activity (self-reported); and muscle flexibility (measured using the fingertip-to-floor test). The treatment program includes 11 exercises that must be administered bilaterally. A mobile app will be developed where each patient will be able to observe the exercises to be carried out. Each session will last 15 minutes with 5 physiotherapy sessions per week for a period of 3 months. It is expected that patients with hemophilia who receive the foam roller intervention will show improvement in mobility, pain, and status of the ankle joint; muscle strength; and function in the lower extremities.

Results
The study has been approved by the institutional review board of the University of Murcia. Patient recruitment will begin in September 2020, and the intervention period will last until June 2021. Data collection will take place between September 2020 and October 2021.

Conclusions
This protocol describes a randomized clinical trial to examine the safety and efficacy of a self-myofascial release intervention using a foam roller in patients with hemophilic ankle arthropathy.

Trial Registration
ClinicalTrials.gov NCT03914287; http://clinicaltrials.gov/ct2/show/NCT03914287.

International Registered Report Identifier (IRRID)
PRR1-10.2196/15612
High School Students’ Preferences and Design Recommendations for a Mobile Phone–Based Intervention to Improve Psychological Well-Being: Mixed Methods Study
Authors: Müssener Ulrika , Thomas Kristin , Bendtsen Preben , Bendtsen Marcus 
Published: April 2020

Background
Young adults’ mental health is characterized by relatively high rates of stress and anxiety and low levels of help-seeking behavior. Mobile health (mHealth) interventions could offer a cost-effective and readily available avenue to provide personalized support to young adults. More research needs to be directed at the development of mHealth interventions targeting youths specifically, as well as at determining how to reach young people and how to effectively intervene to improve psychological well-being.

Objective
The objective was to gather perceptions from high school students to inform the development of a prototype mHealth intervention aiming to promote psychological well-being.

Methods
A mixed methods design was used to (1) investigate high school students’ perceptions about stress and its consequences in daily life, as well as their ability to cope with stress, and (2) explore their preferences and design recommendations for an mHealth intervention to improve psychological well-being. Students from two high schools in the southeast of Sweden were invited to take part in the study. Recruitment of high school students was completed over a 6-week period, between October 25 and December 7, 2018. Recruitment entailed inviting students to complete a stress test (ie, screening and feedback) on their mobile phones. After completing the stress test, all participants were invited to complete a follow-up questionnaire and take part in telephone interviews.

Results
A total of 149 high school students completed the stress test, of which 68 completed the questionnaire. There were 67 free-text comments distributed across the items. The majority of participants (55/68, 81%) stated that they coped with stress better or in the same way after engaging in the stress test, due to time management, dialogue with others, and self-refection. A total of 4 out of 68 participants (6%)—3 female students (75%) and 1 male student (25%)—took part in telephone interviews. Three main themes were identified from the interview data: perceptions about stress, design features, and intervention features.

Conclusions
Stress was described by the students as a condition caused by high demands set by oneself and the social environment that impacted their physical health, personal relationships, school performance, and emotional well-being. Participants claimed that mHealth interventions need to be clearly tailored to a young age group, be evidence based, and offer varied types of support, such as information about stress, exercises to help organize tasks, self-assessment, coping tools, and recommendations of other useful websites, literature, blogs, self-help books, or role models. Mobile phones seemed to be a feasible and acceptable platform for the delivery of an intervention.
Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD
Authors: Srivastava Anand , Cai Xuan , Lee Jungwha , Li Wei , Larive Brett , Kendrick Cynthia , Gassman Jennifer J. , Middleton John P. , Carr James , Raphael Kalani L. , Cheung Alfred K. , Raj Dominic S. , Chonchol Michel B. , Fried Linda F. , Block Geoffrey A. , Sprague Stuart M. , Wolf Myles , Ix Joachim H. , Prasad Pottumarthi V. , Isakova Tamara 
Published: April 2020

Background and objectives
Kidney functional magnetic resonance imaging (MRI) requires further investigation to enhance the noninvasive identification of patients at high risk of CKD progression.

Design, setting, participants, & measurements
In this exploratory study, we obtained baseline diffusion-weighted and blood oxygen level–dependent MRI in 122 participants of the CKD Optimal Management with Binders and Nicotinamide trial, which was a multicenter, randomized, double-blinded, 12-month, four-group parallel trial of nicotinamide and lanthanum carbonate versus placebo conducted in individuals with eGFR 20–45 ml/min per 1.73 m2. Lower values of apparent diffusion coefficient (ADC) on diffusion-weighted MRI may indicate increased fibrosis, and higher values of relaxation rate (R2*) on blood oxygen level–dependent MRI may represent decreased oxygenation. Because there was no effect of active treatment on eGFR over 12 months, we tested whether baseline kidney functional MRI biomarkers were associated with eGFR decline in all 122 participants. In a subset of 87 participants with 12-month follow-up MRI data, we evaluated whether kidney functional MRI biomarkers change over time.

Results
Mean baseline eGFR was 32±9 ml/min per 1.73 m2, and mean annual eGFR slope was −2.3 (95% confidence interval [95% CI], −3.4 to −1.1) ml/min per 1.73 m2 per year. After adjustment for baseline covariates, baseline ADC was associated with change in eGFR over time (difference in annual eGFR slope per 1 SD increase in ADC: 1.3 [95% CI, 0.1 to 2.5] ml/min per 1.73 m2 per year, ADC×time interaction P=0.04). This association was no longer significant after further adjustment for albuminuria (difference in annual eGFR slope per 1 SD increase in ADC: 1.0 (95% CI, −0.1 to 2.2) ml/min per 1.73 m2 per year, ADC×time interaction P=0.08). There was no significant association between baseline R2* and change in eGFR over time. In 87 participants with follow-up functional MRI, ADC and R2* values remained stable over 12 months (intraclass correlation: 0.71 and 0.68, respectively).

Conclusions
Baseline cortical ADC was associated with change in eGFR over time, but this association was not independent of albuminuria. Kidney functional MRI biomarkers remained stable over 1 year.

Clinical Trial registry name and registration number
CKD Optimal Management with Binders and Nicotinamide (COMBINE), NCT02258074.
Benefits and challenges of assessing real-world genomics data with Bogi Eliasen
Authors: Eliasen Bogi 
Published: April 2020

In this video Bogi Eliasen, Copenhagen Institute for Futures Studies, discusses various issues relating to studying population genomics as well as the applications and management of person centric data. As co-initiator of the FarGen project, the first nationwide genome sequencing and implementation project, as well as author of a recently published white paper, the Nordic Way, Bogi provides his thoughts on the wider implications of these projects from European and global healthcare perspectives. Bogi also outlines the aim of the Futureproofing Healthcare Sustainability Index as a platform to help healthcare decision makers use data from a range of healthcare issues to understand the challenges of healthcare provision across Europe.
Antibacterial Activity of Ethanolic Extract of Kitolod (Hippobromalongiflora) Leaf Against Staphylococcus aureus and Salmonella typhi
Authors: Anjelina Simanjuntak Helen 
Published: April 2020

Objective: The purpose of this study was to determine at what concentration of ethanol extract of kitolod leaves is active against Staphylococcus aureus and Salmonella typhi.
Methods: Ethanolic extract of Kitolod leaves was tested for phytochemical screening by using standard protocol. Antibacterial testing was using the diffusion disc method to measure the inhibition zone against the Staphylococcus aureus and Salmonella typhi with various concentration of Kitolod leaves extract (6.25%, 12.5%, 25%, 50%, and 75%).
Results: Phytochemical screening showed that ethanolic extract of Kitolod leaves contain alkaloids, flavonoids and saponins. The antibacterial inhibition of ethanol extract of kitolod leaves against Staphylococcus aureus and Salmonella typhi bacteria at a concentration of 75% had a diameter of 11.3 mm and 12.16 mm with a strong category.
Conclusions: Kitolod leaf could be use as a novel antibacterial agent.
Distribution of Vascular Bundles and Physical Properties Analysis of Variety DxP Oil Palm Trunk Based on Various Zones and Trunk Heights
Authors: Wulandari Ayu , Erwinsyah Erwinsyah 
Published: April 2020

In an attempt to obtain a homogenous board density from the palm trunk, this research was carried out to analyze the distribution of vascular bundles and the physical properties of the oil palm trunk (moisture content, density, and specific gravity) in various zones and trunk heights. Oil palm trunk samples were used from 29 years old palm (Planted on 1991) which acquired from Aek Pancur Experimental plantation, Indonesian Oil Palm Research Institute (IOPRI). The oil palm trunk sample was cut based on the trunk zones (peripheral, central, and inner), and trunk heights (1, 2, 3, 4, 5, 6, 7 m). The observed parameters were vascular bundles, moisture content, density, and specific gravity. The results showed that the highest number of vascular bundles in the peripheral zone (73.66 vb/cm2). In addition that, the highest density and specific gravity also found in peripheral zone with an average 0,73 gram/cm3 and 0.53, whereas the highest moisture content was found in the inner zone with an average value 141%(w/w). Furthermore, the statistical analysis ((ANOVA and regression test (R2)) in this study showed that the trunk zone factor was more significant than the trunk height for all observed parameters (distribution of vascular bundles, moisture content, density and specific gravity).
Pengaruh Waktu Paparan Zat Pengatur Tumbuh Terhadap Tingkat Abnormalitas Klon Kelapa Sawit
Authors: Pratiwi Dian Rahma , Wening Sri , Nazri Erwin 
Published: April 2020

Salah satu komponen yang sering terdapat dalam media kultur jaringan tanaman adalah Zat Pengatur Tumbuh (ZPT), yang diperlukan untuk merangsang pertumbuhan kultur tanaman. Pemberian ZPT yang berlebihan dapat memberikan dampak abnormalitas pada tanaman klon hasil kultur jaringan. Diperlukan kajian untuk mengetahui pengaruh waktu paparan ZPT terhadap tingkat abnormalitas klon secara komprehensif. Penelitian ini bertujuan untuk mengetahui pengaruh total waktu paparan ZPT serta waktu paparan beberapa media dengan kandungan ZPT yang berbeda terhadap tingkat abnormalitas tanaman klon kelapa sawit di lapangan. Empat galur tanaman hasil kultur jaringan (klon) kelapa sawit yakni P, Q, R, dan S yang berumur 4 tahun digunakan untuk penelusuran waktu inkubasi kultur di laboratorium dan pengamatan tingkat abnormalitas di lapangan. Hubungan antara peubah dianalisis menggunakan analisis korelasi dan analisis regresi linier berganda serta analisis regresi linier sederhana. Hasil menunjukkan bahwa total waktu paparan kultur pada media yang mengandung ZPT berpengaruh secara nyata pada tingkat abnormalitas klon di lapangan. Semakin lama waktu paparan (lebih dari 171 hari), semakin tinggi tingkat abnormalitas klon. Dari ketiga jenis media kultur yang mengandung ZPT, media yang mengandung 2,4-D dan 2,4,5-TCPP memiliki pengaruh yang signifikan dan hubungan positif yang sangat erat terhadap kejadian abnormalitas klon dibandingkan media yang mengandung 2,4-D dan BAP. Lama waktu paparan dengan NAA tidak berpengaruh nyata terhadap tingkat abnormalitas klon di lapangan. Sebaliknya, total waktu inkubasi media kultur yang tidak mengandung ZPT tidak mempengaruhi tingkat abnormalitas klon di lapangan dan hubungannya negatif. Model linier dapat digunakan untuk memperkirakan tingkat abnormalitas klon yang dihasilkan berdasarkan waktu paparan ZPT pada proses in vitro.
Determination the Effectiveness of a selected formulations of Iranian Traditional Medicine â€œUshaq poulticeâ€ (ammoniacum gum ointment) on Wound Healing: an experimental study
Authors: Zaheri Abdevand Zeinab , Siahpoosh Amir , Malayeri Alireza , Salami Anayatollah , Khorsandi Layasadat 
Published: April 2020

Objective: The purpose of this study was to evaluate the therapeutic effects of ammonium gum ointment on wound healing in the animal model.
Method: 32 male Wistar rats were selected; then in non-infectious condition, two full-thickness wounds with 8 mm in diameter were created bilaterally on shaved skin in 1.5 cm from the dorsal midline and randomly divided into four groups, untreated group, phenytoin cream treated group, base ointment (sesame oil and wax) treated group and Ammonicuma Gum Ointment (AGO) treated group. The animals received these medicines once daily. On days 5, 7, 10, 12 and 14 wound area was measured. On days 7 and 14, blood samples were taken, and serum level of growth factors (EGF, PDGF, VEGF, and TGF-B) were measured. Skin samples used for hematoxylin-eosin and trichrome staining. Skin tensile strength and hydroxyproline content of skin tissues also measured.
Results: The percentage of wound healing after 14 days of treatment was significantly increased in the group receiving AGO (PË‚0.05). Hydroxyproline content of repaired tissue and tensile strength increased considerably in this group (PË‚0.001). Growth factors were significantly increased in animals treated with AGO compared to control groups (EGF PË‚0.05; PDGF PË‚0.001; VEGF PË‚0.001; TGF-B PË‚0.05). Histological data showed that the topical application of AGO compared to other groups resulted in positive effects on enhance neovascularization and granulation, increased wound healing rate, and decreased wound size.
Conclusion: The topical application of an ointment containing ammoniacum gum can help speed up the process of wound healing.
Administration of Thymoquinone Offer a Protective Effect through the Apoptogenic and Antioxidant Pathway in Acute Liver Failure induced by Taxol
Authors: Salahshoor Mohammad Reza , Roshankhah Shiva , Jalili Cyrus , Farmandeh Amir 
Published: April 2020

Objectives Due to the increasing use of chemotherapy drug and herbs in medicine, this study was designed to assess the effects of Thymoquinone and Taxol on apoptogenic, oxidative and histomorphometric changes in liver.
Methods Sixty-four male rats were assigned to 8 groups including control groups (normal group and Taxol (20 mg/kg group), Thymoquinone groups (4.5, 9, 18 mg/kg) and Taxol + Thymoquinone (TT) treated groups. All experimental groups were treated intraperitoneally daily for two weeks. The relative expression level of apoptotic genes and hepatocyte apoptotic index were analyses. Also, Nitrite oxide (NO), lipid peroxidation (LP), total antioxidant capacity (TAC), hepatic enzymes and histomorphometric parameters were evaluated.
Results In the Taxol control group (TCG) all parameters investigated in this study significantly increase except TAC level, which was decreased in compared to the normal control group (NCG) (P < 0.01). Additionally, all evaluated parameters were reduced in Thymoquinone and TT groups, except TAC level (which was increased) as compared to the TCG (P < 0.01).
Conclusion Our results discovered that Thymoquinone successfully moderate liver injury induced by Taxol through the activation of antioxidant pathways, reduce the apoptogenic and the regeneration of histopathological alterations.
EXAMINING THE USE BEHAVIOUR OF AUGMENTED REALITY TECHNOLOGY THROUGH MARLCARDIO: ADAPTING THE UTAUT MODEL
Authors: Mohd Nizar Nur Nabihah , Rahmat Mohd Khairezan , Maaruf Siti Zuraida , Damio Siti Maftuhah 
Published: April 2020

Augmented reality (AR) is one type of learning process that can be applied through mobile learning known as mobile augmented reality. AR offers an innovative learning space through an active interaction of superimposing digital contents into the real context to enhance learning experiences. Previous studies have found that AR in education is able to lead students to achieve higher levels of engagement in the learning process. In contrast, the potential of AR in education has not been explored intensively. Therefore, this article is to look into factors that might influence pre-service teachers' use behaviour of Mobile Augmented Reality Learning Cardiovascular (MARLCardio). A self-designed MARLCardio app has been used as an experimental instrument in collecting data. The influencing factors towards use behaviour of MARLCardio are performance expectancy, effort expectancy, social influence and facilitating conditions. This study is a part of an on-going research. In this study, a total of 75 respondents used MARLCardio app before answering a survey questionnaire. The respondents were pre-service teachers at one public university in Malaysia. All data from the questionnaire were analysed using multiple regression analysis. As a result of this investigation, findings showed that effort expectancy is the dominant factor in determining the use behaviour of MARLCardio. Interestingly, performance expectancy did not show any significant relationship.
KEYWORDS: Augmented Reality, Mobile Augmented Reality, UTAUT Model, Technology Adoption Model, Use Behaviour
English Informal Language Learning through Social Networking Sites Among Malaysian University Students
Authors: Ismail Izaham Shah , Shafie Nurul Hidayu 
Published: April 2020

The use of ICT in education has benefitted both students and educators in the education field. Currently, social networking sites are being used widely by university students in their daily lives for various purposes such as entertainment, networking, as well as educational purposes. There are many studies conducted to figure out whether the social networking sites benefit the students in formal education but there are not many studies done to investigate whether they are beneficial to students’ informal learning, especially in English language. Therefore, this study aims to investigate the contribution of social networking sites to the university students' English informal language learning. This quantitative study was conducted on Malaysian public university students in Selangor and Negeri Sembilan. A descriptive quantitative survey research was conducted in order to answer the research questions of this study. The results of this study revealed that most of the respondents learned English informally by saving interesting English quotes or images posted on social networking sites as well as by paying attention to the sentence patterns and accent while watching videos on those sites. The respondents of this study also perceived that they informally learned listening skills and vocabulary the most from the social networking sites. To conclude, social networking sites are not only useful for entertaining purposes, but they could also be used to informally learn and improve one’s English language skills.

KEYWORDS: Language Learning, English Informal Learning, Social Networking Sites, Millennials, English In Social Networking Sites, ICT In Education
Digital Storytelling for 21st Century Learning: A Study on Pre-Service Teachers’ Perception
Authors: Dalim Siti Fairuz , Muhamad Azliza Nurul Zakiah , Ibrahim Norezah , Zulkipli Zulinda Ayu , Mohd Yusof Mohammad Mubarrak 
Published: April 2020

Digital Storytelling is one of the new pedagogical tools that call upon students’ creativity and helps them to “learn by doing”. It is one of the important steps towards creating the 21st-century learning environment as it promotes the integration of student-centred and technology-enriched learning environment for learners. Despite the many benefits that this learning tool has to offer, many educators are still reluctant to integrate this kind of technology in their classes which resulted in low implementation of this technology among the educators. Therefore, this study is intended to determine pre-service teachers’ experience and perceptions of digital storytelling for 21st-century skills in a learning environment. A set of questionnaire was distributed to 150 trainee teachers from the Faculty of Education in one of the public universities in Malaysia. The result of this study reveals that pre-service teachers’ have moderately experienced the use of digital storytelling in their learning (M=2.98; SD=1.332). The finding also showed that the pre-service teachers responded positively towards the use of digital storytelling in the classroom (M=3.94; SD=0.713). The correlation analysis further showed that the pre-service teachers’ experience with digital storytelling has significantly given the impact on their perception towards the implementation of this tool in the teaching and learning process. Considering the many advantages of the digital storytelling towards the enhancement of 21st-century skills among the younger generations, therefore more aggressive steps need to be done to strengthen the teaching preparation programme in higher educational institutions. This is very important to ensure that the future teachers produced are well-equipped with all the teaching skills and technologies to educate the next millennial generations.
KEYWORDS: 21st-century learning, Millennial, Digital storytelling, Pre-service teachers, Student-centered