bluuebunny/crossref_metadata_2025_split huggingface dataset:
The economic essence of innovative susceptibility of the organization
Authors: Lapitskaya Larisa , Yemelyanchenko Yanina 
Published: December 2019

Currently, the relevance of the country's innovative development is justified not only by external challenges in the world economy, but also by the internal need for an economically balanced development of the subjects of the real sector of the economy. At the same time, the activation of innovative activity of economic entities is impossible without increasing the level of their innovative susceptibility. It should be noted that despite the general interest of the scientific community in the innovative development of the economy and the large publication of works on this topic, the interpretation of the concept of «innovative susceptibility» is still freely interpreted and not enshrined in any legislative act. The purpose of the article is the author's study of the economic essence of innovative susceptibility of the organization. The study of this problem is based on general scientific methods of knowledge of economic phenomena and processes (analysis and synthesis, system approach, dialectical method, etc.). The article presents the author's rethinking of the concept of innovative receptivity of the organization. Based on the analysis of existing concepts on the issue under consideration, the authors formulate a refined interpretation of the concept of «innovative susceptibility» at the level of the organization and consider the main categories associated with this concept. It is established that the innovative activity of the organization is not possible without its innovational susceptibility. In turn, innovative susceptibility is not possible without motivated staff and the mood of the business entity to use its innovative potential to increase competitiveness. Conclusions and results of the article can be used in the educational and scientific process of economic faculties of higher educational institutions. During the writing of the article, the lack of a unified approach to the interpretation of the concept of innovative susceptibility of the organization was revealed, despite the great interest in the problems of innovative development of organizations in the modern post-industrial world. Therefore, the author's interpretation of the economic essence of innovative susceptibility of the organization was formulated. The subject, object, reasons and conditions of innovative susceptibility of the organization are defined.
SELENIUM WEB DRIVER NA EVOLUÇÃO DOS TESTES MANUAIS
Authors: Romanini Isabela Ziviani , Sotto Eder Carlos Salazar 
Published: December 2019

Com a evolução dos modelos de gerenciamento de projetos, as práticas de métodos ágeis (Scrum) com seus ciclos curtos de desenvolvimento e seus times enxutos, impactam significativamente no modo como os testes de software hoje são feitos, por exemplo, executar um teste de regressão após uma mudança no código de maneira manual acaba sendo oneroso gastando muito tempo do analista de teste e gerando um custo a mais para a empresa. Com isso surgiram novas maneiras de se fazer testes de software, são eles os testes automatizados. Encontramos inúmeras ferramentas para a aplicação desses testes. Este artigo aborda por meio de vivências e pesquisas uma introdução para aplicação de automação de testes utilizando o framework Selenium WebDriver e o TestNG. No final, os profissionais interessados na área de teste terá uma base sobre como aplicar as ferramentas para aumentar a confiabilidade e a agilidade na execução de casos de teste.
UMA FERRAMENTA COMPUTACIONAL PARA APOIO À GESTÃO DE ATIVIDADES NO CONTROLE DE QUALIDADE DE EMBALAGENS
Authors: Barbosa Rodolfo Emanoel , Campos Ronaldo Ribeiro de 
Published: December 2019

Este artigo apresenta um estudo sobre o desenvolvimento de uma ferramenta computacional para auxiliar na gestão de um departamento de Controle de Qualidade de Embalagens, no ramo farmacêutico veterinário. Tendo em vista a grande quantidade de informações e documentos pertinentes ao setor, a ferramenta propõe um modelo de organização destes dados, automatizando processos de emissão de documento e evitando dados redundantes. Para tal, realizou-se uma pesquisa bibliográfica e análise da aplicação, visualizando seus métodos de organização e disponibilização de informações, resultando em impactos positivos no lead time dos processos.
IMPORTÂNCIA DO CICLO PDCA APLICADO À PRODUTIVIDADE DA INDÚSTRIA NO BRASIL
Authors: Gomes Filho Valdeci , Gasparotto Angelita Moutin Segoria 
Published: December 2019

O Clico PDCA tem sido usado atualmente pelas empresas na execução e seu planejamento estratégico de forma eficiente e dinâmica. A qualidade dos serviços oferecidos pelas empresas é um diferencial necessário para a sua sobrevivência no mercado, sendo assim, a determinação de processos se mostra como fator determinante no desenvolvimento dos negócios, já que o Brasil conta com um contingente de milhares de indústrias, as quais têm grande importância no cenário econômico do país, e uma participação significativa no Produto Interno Bruto (PIB). A utilização do ciclo PDCA no ambiente organizacional é um caminho para melhorar os resultados e alavancar o desempenho das empresas. O Ciclo de Qualidade, como uma metodologia que visa auxiliar no diagnóstico e no prognóstico de problemas nas organizações e possui como foco na melhoria contínua de processos de qualquer natureza. Para sua implementação, é necessário um estudo de todas as suas etapas.
TATA KELOLA ANGGARAN DESA YANG BERSUMBER APBN DALAM RANGKA MEWUJUDKAN PEMBANGUNAN MASYARAKAT PINGGIRAN BERBASIS PEMERATAAN PEMBANGUNAN PEDESAAN DALAM PERSPEKTIF NAWA CITA (STUDI KASUS DI WILAYAH CIAYUMAJAKUNING)
Authors: Sugianto Sugianto , Leliya Leliya , Ubaidillah Ubaidillah 
Published: December 2019

Rural development in an integral part of regional development and national development as an effort to improve the quality of community’s life. The implementation of this rural development program is very important in the context of national development because rural areas occupy the largest portion in the entire country. The purpose of this study was to find out the village budget management sourced from the state budget in order to realize rural community development based on rural development in the perspective of Nawa Cita and the role of the village government in running the Nawa Cita program on peripheral community development on village government budget management based on people’s interest in order to realize equitable development.
This study used a qualitative approach in order to investigate and understand the phenomena such as what happens, why it happens, and how it happens while understanding a social situation, events, and interaction roles. Data collection was carried out by conducting interview with the Head of BPMPD Department of Cirebon Regency, the Head of BPMPD Department of Kuningan Regency, the Head of BPMPD Department of Majalengka Regency and the Head of BPMPD Department of Indramayu Regency and all village heads in Cirebon, Indramayu, Majalengka, and Kuningan Regions. As well as the data were obtained from the documents in regency, disctrict, and village.
The result of this study showed that village as the frontline of the development has strategic role in the success of the Nawa Cita Program. The village budget management is based on the principle of transparency, accountability, participatory, efficient, effective, orderly and budgetary discipline by paying attention to the justice principles, propriety and benefits for the village community. The implementation of activities in the APBD is carried out by the implementing team consisting of the elements from village apparatus and community institutions and supervised by the BPD, at the end of each fiscal year the Village Head has the obligation to submit a village government management report (LPPD) to the regional head through sub-district head and submit information to the LPPD to the BPD.
PERLINDUNGAN HAK ATAS KEKAYAAN INTELEKTUAL BATIK TRADISIONAL PAOMAN DALAM MENINGKATKAN EKONOMI MASYARAKAT INDRAMAYU
Authors: Suratno Ujang 
Published: December 2019

Indonesia has some varieties of ethnic groups that are rich in diversity of intellectual property, there are so many products produced by society. The society creations especially created by the community are assorted, one of them is Paoman Batik. Thre are two kinds of Paoman Batik, those are contemporary and traditional, which is distinguished by its motives, processes, creators. The Paoman Traditional Batik is well-known to the public than contemporary. This research has supported the creators or copyright holders to get higher benefits, both the benefits of moral and economic rights. The main problem is, first, is the current intellectual property rights regime able to provide the foundation for the protection of Paoman Traditional Batik? Second, is the UNESCO's determination that stated if batik is a world heritage, non-object from Indonesia, can be used as the foundation to charge the economic rights of Paoman Traditional Batik? Third, is it possible for Traditional Batik, including Paoman Traditional Batik, to be carried out through other regimes, in addition to the intellectual property regime? Fourth, how is the effect of Paoman Traditional Batik Registered at the Directorate General of Intellectual Property of Indonesia on the Progress of Indramayu society?
The research method used is descriptive specification, by using juridical empirical approach, which focus on secondary research consisting of legal materials, both primary, secondary and tertiary. However it is supported by primary data generated from field research through in-depth interview and survey techniques. The analysis used is descriptive analysis.
The results of the study show that intellectual property rights that is copyright cannot be made as the foundation of protection against the creation of society that have traditional and communal motives, including the Paoman Tradsional Batik. The establishment of Batik by UNESCO as a non-object world heritage from Indonesia has increased the moral rights of Indonesia, but it also cannot be established as the foundation for restoring economic rights when there is a misappropriation. Another alternative to intellectual property is through the Sui Generis regime, which specifically addresses the protection of community rights, including intellectual property rights.
KEWENANGAN PELAKSANA TUGAS MENTERI DALAM MENGAMBIL KEPUTUSAN DAN TINDAKAN YANG BERSIFAT STRATEGIS BERDASARKAN UNDANG - UNDANG NOMOR 30 TAHUN 2014 TENTANG ADMINISTRASI PEMERINTAHAN
Authors: Egi Dwitama Sigit 
Published: December 2019

One form of decree that is included in the scope of state administration is a Ministerial Decree, which is a decision determined and issued by a minister who is always concrete-individual in the form of administrative stipulations (beschikking). However, not all departments and/or government officials such as the Minister have the authority to form these decisions, because in forming decisions can be seen from the status of government officials as an example of the Ad Interim Minister who does not have the authority to issue strategic decisions. But different problems arise when there is Ad Interim of Energy and Mineral Resources Minister Luhut Binsar Pandjaitan issued Decree Number 6752 K / 70 / MEM / 2016 concerning Dissolution of Ad Hoc Organizational Units in the Ministry of Energy and Mineral Resources, which basically was a strategic decision.
This study is a legal research using a normative juridical approach and descriptive analytical research specifications. The data used in this study are secondary data consisting of primary, secondary and tertiary legal materials. Data obtained through library studies and field research in the form of legislation, books, journals, and electronic media.
The results of this study consist of 2 (two) analyzes, namely First, the position of the Acting Decree of the Minister of ESDM does not have legal validity because there is a disability when viewed from the aspect of authority, formation process, and the purpose of its establishment with legislation and AUPB and Second, towards legal validity which is not possessed by the Minister's decree executor, the decree becomes invalid and a mechanism is needed to cancel the decree.
The Topological Connectivity of the Independence Complex of Circular-Arc Graphs
Authors: ABD ALGANİ Yousef 
Published: December 2019

Let us denoted the topological connectivity of a simplicial complex $C$ plus 2 by $\eta(C)$. Let $\psi$ be a function from class of graphs to the set of positive integers together with $\infty$. Suppose $\psi$ satisfies the following properties: \newline $\psi{(K_{0})}$=0. \newline For every graph G there exists an edge $e=(x,y)$ of $G$ such that $$\psi{(G-e)}\geq{\psi{(G)}}$$ (where $G-e$ is obtained from $G$ by the removal of the edge $e$), and $$\psi{(G-N(\lbrace x,y \rbrace))}\geq{\psi{(G)}}-1$$ then $$\eta{(\mathcal{I}{(G)})}\geq\psi{(G)}$$ (where $(G-N(\lbrace x,y \rbrace))$ is obtained from $G$ by the removal of all neighbors of $x$ and $y$ (including, of course, $x$ and $y$ themselves). Let us denoted the maximal function satisfying the conditions above by $\psi_0$. Berger [3] prove the following conjecture: $$\eta{(\mathcal{I}{(G)})}=\psi_{0}{(G)}$$ for trees and completements of chordal graphs. Kawamura [2] proved conjecture, for chordal graphs. Berger [3] proved Conjecture for trees and completements of chordal graphs. In this article I proved the following theorem: Let $G$ be a circular-arc graph $G$ if $\psi_0(G)\leq 2$ then $\eta(\mathcal{I}(G))\leq 2$. Prior the attempt to verify the previously mentioned cases, we need a few preparations which will be discussed in the introduction.
Solutions of a System of Two Higher-Order Difference Equations in Terms of Lucas Sequence
Authors: HALİM Yacine , KHELİFA Amira , BERKAL Massaoud 
Published: December 2019

In this paper we give some theoretical explanations related to the representation for the general solution of the system of the higher-order rational difference equations $$ x_{n+1} = \frac{5 y_{n-k}-5}{y_{n-k}}, \qquad y_{n+1} = \frac{5 x_{n-k}-5}{x_{n-k}} ,\qquad n, k\in \mathbb{N}_0, $$ where $\mathbb{N}_{0}=\mathbb{N}\cup \left\{0\right\}$, and the initial conditions $x_{-k}$, $x_{-k+1},\ldots$, $x_{0}$, $y_{-k}$, $y_{-k+1},\ldots$, $y_{0}$ are non zero real numbers such that their solutions are associated to Lucas numbers. We also study the stability character and asymptotic behavior of this system.
Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research
Authors: Fischer Corinne E. , Ismail Zahinoor , Youakim James M. , Creese Byron , Kumar Sanjeev , Nuñez Nicolas , Ryan Darby R. , Di Vita Antonella , D’Antonio Fabrizia , de Lena Carlo , McGeown William J. , Ramit Ravona , Rasmussen Jill , Bell Joanne , Wang Huali , Bruneau Marie-Andrée , Panegyres Peter K. , Lanctôt Krista L. , Agüera-Ortiz Luis , Lyketsos Constantine , Cummings Jeffrey , Jeste Dilip V. , Sano Mary , Devanand D.P. , Sweet Robert A. , Ballard Clive 
Published: December 2019

Background: Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice. Objective: To establish research criteria for the diagnosis of psychosis in AD. Methods: The International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria. Results: Consensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers. Conclusion: We propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.
An Exploratory Phase IIa Study of the PPAR delta/gamma Agonist T3D-959 Assessing Metabolic and Cognitive Function in Subjects with Mild to Moderate Alzheimer’s Disease
Authors: Chamberlain Stanley , Gabriel Hoda , Strittmatter Warren , Didsbury John 
Published: December 2019

Background: T3D-959 is a chemically unique, brain penetrant, dual PPAR delta/gamma agonist with 15-fold higher PPAR delta selectivity. Ubiquitous brain expression of PPAR delta, its critical role in regulating glucose and lipid metabolism, and the Alzheimer’s disease (AD)-like phenotype of PPAR delta null mice motivated this study. Objective: To determine safety and tolerability of multiple doses of T3D-959 in subjects with mild to moderate AD, examine systemic and central drug pharmacology and in an exploratory manner, perform cognitive assessments. Methods: Thirty-four subjects with mild-to-moderate AD were orally administered 3, 10, 30, or 90 mg of T3D-959 daily for 14 days. There was no inclusion of a placebo arm. Safety and tolerability were monitored. Systemic drug pharmacology was examined via plasma metabolomics LC-MS-MS analysis, cerebral drug pharmacology via FDG-PET measures of changes in Relative CMRgl (R CMRgl, AD-effected regions relative to brain reference regions), and cognitive function assessed before and after drug treatment and again one week after completion of drug treatment, by ADAS-cog11 and the Digit Symbol Substitution Test (DSST). Results: T3D-959 was in general safe and well tolerated. Single point pharmacokinetics at the Tmax showed dose dependent exposure. Plasma metabolome profile changes showed dose-dependent systemic effects on lipid metabolism and metabolism related to insulin sensitization. Relative FDG-PET imaging demonstrated dose-dependent, regional, effects of T3D-959 on R CMRgl based on the use of multiple reference regions. ADAS-cog11 and DSST cognitive assessments showed improvements with possible ApoE genotype association and pharmacodynamics related to the mechanism of drug action. Conclusions: Exploratory data from this Phase IIa clinical trial supports further clinical investigation of T3D-959 in a larger placebo-controlled clinical study.
Global Vascular Risk Score and CAIDE Dementia Risk Score Predict Cognitive Function in the Northern Manhattan Study
Authors: Rundek Tatjana , Gardener Hannah , Dias Saporta Anita Seixas , Loewenstein David A. , Duara Ranjan , Wright Clinton B. , Dong Chuanhui , Levin Bonnie , Elkind Mitchell S.V. , Sacco Ralph L. 
Published: December 2019

Background: Modifiable vascular risk factors (VRF) have been implicated in cognitive impairment. Objective: We compared the prediction of cognitive performance between the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score, a validated tool to estimate dementia risk using VRF, and the Northern Manhattan Study (NOMAS) global vascular risk score (GVRS), created to predict vascular events. Methods: The CAIDE and GVRS scores were calculated based on baseline VRF among 1,290 stroke-free participants in the prospective population-based NOMAS MRI cohort (mean age 64±8 years, 60% women; 66% Hispanic, 17% Black, 15% White; 46% completed high school). Domain-specific Z-scores were derived for episodic and semantic memory, executive function, and processing speed, and averaged to calculate global cognition. Results: The CAIDE score was associated with worse global cognition at initial assessment (Beta per SD = –0.347, p < 0.0001), and with greater decline over time (Beta per SD = –0.033, p = 0.02). These associations were largely due to age and education, and the association with cognitive decline was not significant after adjusting for age, sex, and education. The GVRS was inversely associated with global cognition at initial testing (Beta per SD = –0.247, p < 0.0001) and greater decline over time (Beta per SD = –0.127, p < 0.0001), which persisted after adjusting for sociodemographics. The associations for both scores with initial cognitive performance were driven by executive function and processing speed, and the GVRS was associated with decline in episodic memory and processing speed. Conclusions: The GVRS was a stronger predictor of cognitive decline than the CAIDE in a multi-ethnic urban cohort. The inclusion of glucose and smoking in the GVRS, which are absent in CAIDE, likely explains the better performance of the GVRS.
Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer’s Disease and Vascular Dementia
Authors: Liu Hanxiang , Reynolds Gavin P. , Wei Xianwen 
Published: December 2019

Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and is thought to have protective effects against neurodegenerative processes. However, UA is also implicated as a risk factor in vascular, including cerebrovascular, disease. Its association with, and role in, dementia and its component diseases including Alzheimer’s disease (AD) and vascular dementia (VaD) remains unclear and inconsistently studied. Changes in blood lipids, particularly cholesterol measures, have also been implicated in dementias although the relationship or interactions with UA have been little studied. We have measured plasma UA and lipids taken from 187 subjects first attending a general hospital neurology department for symptoms associated with dementia, and from a series of 79 healthy control subjects. Diagnoses of AD and VaD were made following neuroimaging; laboratory measures were compared between dementia and control groups and between AD and VaD subgroups. No overall change in UA was seen in dementia, although a substantial and highly significant reduction was found in the AD patients. Reduced values in total cholesterol, HDL, and LDL were found in dementia, independent of statin treatment. Further investigation found a significant reduction of HDL only in the VaD group, while total cholesterol was significantly reduced in both AD and VaD subjects. These findings indicate that in our Chinese sample, UA deficits are specifically associated with AD, while deficits in HDL cholesterol found in dementia tend to be greater in VaD.
Macrophages — a perspective target for antineoplastic immunotherapy
Authors: Karaman О.М. , Ivanchenko A.V. , Chekhun V.F. 
Published: December 2019

Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity.