bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGN AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN PRODUCED USING DETARIUM MICROCARPUM GUM
Authors: OKAFO SINODUKOO EZIUZO , ALALOR CHRISTIAN ARERUSUOGHENE , ORDU JOHN IKECHI 
Published: September 2020

Objective: The objective of this study was to evaluate sustained release matrix tablets of metformin formulated using Detarium microcarpum gum (DMG) as the matrix polymer.
Methods: DMG was produced by acetone desolvation of the filtrate obtained by maceration of powdered seeds of Detarium microcarpum in distilled water. Metformin matrix tablets were prepared by direct compression technique using DMG or sodium carboxymethylcellulose (NaCMC) alone, or their combinations as the polymer matrix. The tablets were evaluated for hardness, friability, weight uniformity, drug content, swelling behaviour and in vitro dissolution. They were compared to a marketed product.
Results: The results of the evaluation showed that the tablets had physical characteristics that were within the acceptable limits and were comparable to the marketed product. They include hardness (7.13±1.99 to 13.17±1.59 Kgf), friability (0.40 to 0.80%), and drug content (95.11 to 104.17%). Formulations MTF2 (30% DMG) and MTF6 (20% DMG and 10% NaCMC) showed good sustained release behaviour, as they released 75% of the drug within 7 to 9 h and 100% release in more than 12 h.
Conclusion: DMG alone or with NaCMC was successfully used to formulate sustained release metformin matrix tablets that were comparable to the marketed product.
Cenaprov y el crecimiento urbano de Pereira 1973-1987. Una mirada a la construcción barrial de Pereira desde sus márgenes
Authors: Arias Quiceno Otoniel , Restrepo Botero Julián Andrés 
Published: September 2020

El crecimiento exponencial de la población en Colombia y el éxodo masivo de personas del campo a la ciudad a mediados del siglo XX a causa principalmente del fenómeno de la violencia, derivó en carencias habitacionales y en la conformación de invasiones en las ciudades. En ese contexto, la organización social de izquierda Central Nacional Provivienda (CENAPROV), promovió la construcción de diez planes de vivienda en la ciudad de Pereira. La presente investigación es un intento por reconstruir el accionar de CENAPROV desde su aparición en la ciudad en 1973 hasta el inicio de su declive en el año de 1987. Así, de la mano de la Metodología de Reconstrucción Colectiva de la Historia RCH y del análisis crítico de fuentes, se aporta a la comprensión de la historia urbana de Pereira desde sus márgenes.

The exponential growth of the population in Colombia and the massive exodus of people from the countryside to the city in the mid-twentieth century mainly due to the phenomenon of violence, led to housing shortages and the formation of slums in the cities. In this context, the left social organization Central Nacional Provivienda (CENAPROV), promoted the construction of ten housing plans in Pereira city. The present investigation is an attempt to reconstruct the CENAPROV actions since its appearance in the city in 1973 until the beginning of its decline in 1987. Thus, together with the Methodology of Collective Reconstruction of the History RCH and the critical analysis of sources, contributes to the understanding of the urban history of Pereira from its margins.
A Signal Theory Model for Continuous Monitoring and Intelligence Systems
Authors: O'Leary Daniel E. 
Published: September 2020

ABSTRACT
Continuous monitoring and intelligence systems analyze data and text from various sources and use that information to monitor risk, controls, reputations, companies, people, opportunities, competition, and other concerns. We summarize some of the previous literature for such systems and the capabilities of existing continuous monitoring systems. Unfortunately, there has been limited theoretical development for such systems. We view the monitored information sources as providing information signals relating to events, activities, issues, etc. Systems must choose what information sources to monitor and gather information from. Unfortunately, choice of such source systems is not a straightforward problem, but must account for time, cost, redundancy, reliability, relevance, information asymmetries, weak signals, and other issues. Further, analytics must be generated to monitor signals created from the information sources to gather the information needed for the system. Accordingly, this paper generates and applies a signal theory model to address these issues.
Sepsis y shock séptico por Staphylococcus Aureus metilrresistente de la comunidad (SARM- AC) hospital de niños Dr. Roberto Gilbert Elizalde, unidad de cuidados intensivos pediátricos, 2016, reporte de caso
Authors: Paez Pesantes Xavier Ulpiano , Ordóñez Ximena , Sarango Irina , Arboleda Inés , Guayalema Marisol 
Published: September 2020

Los procesos infecciosos constituyen una causa muy importante de morbi-mortalidad a nivel mundial, por lo que se espera que el tratamiento adecuado en el momento oportuno genere un impacto positivo en la Salud Pública. Sin embargo, el tratamiento convencional puede no ser el adecuado cuando se deben combatir microorganismos que han desarrollado mecanismos de resistencia a los antibióticos de primera línea de elección.El presente caso es de interés medico debido a la agresividad con la que se presentó la infección por S. áureos de la comunidad en un paciente de 8 años 11 meses de edad hospitalizado en la Unidad de Cuidados intensivos Pediátricos del Hospital Roberto Gilbert, con cuadro clínico de 4 días de evolución sin antecedentes previos , que se inició con alza térmica no cuantificada , además de dolor e incapacidad funcional de rodilla izquierda, acompañado de dolor abdominal difuso, ictericia en piel y mucosas, además de signos de dificultad respiratoria, que ingreso con datos de respuesta inflamatoria sistémica, con evolución rápida hacia shock séptico con resultados positivos para S. Aureus en Hemocultivos y MARSA, dicho cuadro fue refractario a líquidos y drogas con evolución rápida y signos de falla multiorgánica con SOFA de 13, llegando a fallecer en sus primeras 48 horas de hospitalización en la Unidad. El S. Aureus resistente a meticilina (SARM) ha sido considerado como un patógeno exclusivamente nosocomial asociado en muchas ocasiones a brotes hospitalarios, actualmente es conocido que el SARM está asociado a infecciones adquiridas en la comunidad con alto porcentaje de mortalidad. El objetivo básico de este reporte de caso el dar a conocer la agresividad de este germen para crear estrategias de manejo y sobre todo de prevención de su transmisión en la comunidad.
ASSESSMENT OF PHYTOPLANKTON AS FOOD RESERVE IN MIDDLE CASPIAN
Authors: Zimina T atyana Nikolaevna , Ardabyeva Alevtina Georgievna , Kotelnikov Andrey Vyacheslavovich 
Published: September 2020

The paper considers the specific features of development of the qualitative composition and ecological groups of plankton algae in the Middle Caspian in the summer of 2019. The yearly dynamics of biomass and the number of algae in the sections of Makhachkala - Cape Sagyn-dyk, Derbent - Cape Peschanny, Divichi - Kenderly Bay has been examined. During the study period 109 samples were collected and examined and 110 taxonomic units of algae were found, with diatoms always prevailing. The structure-forming role belonged to freshwater algae (37 %), which became characteristic of this part of the sea. The biomass and number of phytoplankton in the Middle Caspian made 12.9 million copies/m3 and 166.56 mg/m3, respectively. The layer-by-layer distribution of biomass was determined by the intensity of development of the diatomaceous alga Pseudosolenia calcar-avis. The most favorable conditions for vegetation of dinophytic feed organisms were formed in the western (sections of Makhachkala - Cape Sagyndyk, Derbent - Cape Peschanny) and central (Divichi - Kenderly Bay) parts of the section in a layer of 0-25 m, which presumably has a positive effect on the development of planktonic organisms. Small-cell forms
of algae dominated, which is an important aspect in the formation of the fish food reserve.
Can oocytes repair fragmented DNA of spermatozoa?
Authors: Ješeta Michal , Myšková Markéta , Žáková Jana , Crha Igor , Crha Karel , Chmelikova Eva , Kistanova Elena , Ventruba Pavel 
Published: September 2020

Abstract
Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Running title: Oocyte and DNA repair
Cryptocurrencies as an asset class in portfolio optimisation
Authors: Holovatiuk Olha 
Published: September 2020

Abstract
In this paper, cryptocurrencies are analysed as investment instruments. The study aims to verify whether they can be classified as an asset class and what kind of benefits they may bring to the investor's portfolio. We used 6 indices as proxies for the major asset classes, including the cryptocurrency index CRIX, for all cryptographic assets.
Cryptocurrencies relatively fully satisfied 7 asset class requirements, namely stable aggregation, investability, internal homogeneity, external heterogeneity, expected utility, selection skill and cost-effective access. It was found that crypto assets have diversification properties. Portfolio optimisation with the Modern Portfolio Theory showed an increase in the Sharpe ratio of tangency portfolios with the inclusion of CRIX. However, the Post-Modern Portfolio Theory identified significant deterioration of the downside risk and the Sortino ratio.
Radar reflectivity signatures and possible lead times of warnings for very large hail in Poland based on data from 2007-2015
Authors: Pilorz Wojciech , Łupikasza Ewa 
Published: September 2020

Abstract
Hail involving very large hailstones (maximum diameter ≥ 5 cm), is a rare but very hazardous phenomenon in Poland, and can be forecast using reflectivity signatures. Every year, Poland experiences from one to over a dozen storms with such large hailstones. Despite the current recommendations regarding polarimetric techniques used in hail risk monitoring, Poland does not have a fully polarimetric radar network. Therefore it is essential to check hail detection capabilities using only reflectivity techniques based on individual radar systems involving hail detection algorithms such as Waldvogel et al. (1979) or Vertically Integrated Liquid thresholds connected with manual signature analysis to get better warning decisions. This study is aimed to determine the reflectivity features, thresholds and lead times for nowcasting of severe storms with very large hailstones in Poland, using data from the Polish radar system and from the European Severe Weather Database for the period 2007–2015. Most incidents involving very large hailstones were linked to supercell storms with distinctive reflectivity signatures, however, some storms with extremely large hailstones presented very poorly developed signatures. These signatures enabled the prediction of hail involving very large hailstones approximately 29 minutes before it fell. The Lemon (1980) criterion and WER were found to be the best hail predictors for Polish radar system conditions.
Functional traits of okra cultivars (Chinese green and Chinese red) under salt stress
Authors: Azeem Ahmad , Javed Qaiser , Sun Jianfan , Nawaz Muhammad I. , Ullah Ikram , Kama Rakhwe , Du Daolin 
Published: September 2020

Abstract
Two okra cultivars (Chinese green and Chinese red) were subjected to salt stress for 12 weeks. Salt stress treatments T1 (20.8 mM), T2 (103.3 mM), T3 (180.0 mM) and T4 (257.0 mM) were applied with equal proportions of NaCl and CaCl2 in Hoagland nutrient solution. Salt stress significantly affects photosynthesis, transpiration, stomatal conductance, water use efficiency, water potential, plant height, root length, fresh weight and dry weight of both okra cultivars in every salt stress treatment. At T2, T3 and T4, Chinese red plants maintained their physiological and growth traits up to Weeks 9, 6 and 3, respectively; beyond these salt-stress durations, growth reductions were found. Similarly, Chinese green plants maintained their growth up to Weeks 9, 5 and 3, respectively, at T2, T3 and T4 treatments. In comparison, Chinese red showed more tolerance than Chinese green. According to the results, the third and ninth weeks are the tolerance threshold limits for both cultivars to sustain their physiological traits and growth under T4 and T2 salinity treatments. Similarly, Chinese red has the threshold limit to bear T3 treatment up to the eighth week and Chinese green, up to the fifth week. Thus, this study provides a new method to determine the threshold value of crops with respect to duration under salt stress. This finding would be useful in the field of water saving and utilisation of saline water resources.
Intensity of heat stress in 2015 and 2018 summer seasons in the region of the Lower Silesia (Poland)
Authors: Miszuk Bartłomiej 
Published: September 2020

Abstract
The main goal of this paper was to assess the intensity of heat stress in Lower Silesia, Poland, during selected weather events characterized by high air temperatures. The complex impact of weather on the thermal load of the human organism is presented using the Universal Thermal Climate Index (UTCI). The analysis was carried out for the 2015 and 2018 summer seasons and compared with the multiannual period of 1971–2018. It was based on meteorological data from the IMGW-PIB stations of Wrocław, Jelenia Góra and Śnieżka. In order to examine how heat conditions affect UTCI in different geographical regions, stations located at different altitudes and representing the lowlands, the lower mountain zone and the summit zone of the Sudetes Mountains were considered. The research showed that during the most extreme thermal events, UTCI values in the lowlands and the lower mountain zones can be among the highest heat stress classes. In the summit zone, the maximum UTCI values are usually classed as ‘no thermal stress’.
Effects of abiotic factors on co-occurring Carabus (Coleoptera: Carabidae) species
Authors: Fülöp Dávid , Bérces Sándor , Szabó Péter , Samu Ferenc 
Published: September 2020

AbstractThe members of the genus Carabus are among the most intensively studied beetle taxa, but many aspects of their autecology are still unexplored. We aimed to study the relationship between measured abiotic parameters and the spatial and temporal distribution of signature carabid species. Carabus assemblages were sampled by pitfalls at six sites belonging to two nearby locations, both forest habitats: in valley and in hill-top position. The sites showed variation in microclimatic and soil characteristics, to which the seven species caught showed specific spatial associations. Carabus scheidleri and C. coriaceus were ubiquitists, occurring at all sites. The habitat specialist C. violaceus germari indicated valley sites with high humidity, lower temperature, limy soil and higher pH, whereas the other specialists, C. nemoralis and C. convexus were strongly associated with the dry, warm, more acidic hill habitat. Remaining species were associated with specific sites and environmental features. The species also exhibited specific phenological patterns corresponding with their habitat preference. Hill habitat species exhibited peak activity density during the hottest summer period, whereas most other species had an activity depression during that period. The results suggest that although Carabus activity density patterns are species specific, they are largely affected by temperature both spatially and temporally.
PSICOLOGIA ORGANIZACIONAL: ANÁLISE DOS VALORES ORGANIZACIONAIS DE UMA ACADEMIA
Authors: BARBOSA Jordâna Parreira , OLIVEIRA Karem Sabrina da Cruz , FORESTO-DEL COL Denise Rossi 
Published: September 2020

A identidade organizacional de uma empresa é composta de visão, missão e valores e é por meio deste conjunto que a organização apresenta para seus colaboradores o motivo de existir e onde pretende chegar. Os valores organizacionais são formas de conhecer a realidade organizacional e podem ser escolhidos na formação da empresa ou ao longo de sua história, recebendo influência dos fundadores e colaboradores. A partir do exposto, o objetivo deste trabalho foi identificar os valores organizacionais na concepção dos colaboradores e dos gestores dentro de uma academia. Este trabalho caracterizou-se por uma pesquisa quantitativa exploratória e os instrumentos utilizados foram: o Questionário Sociodemográfico, o Inventário de Perfil de Valores Organizacionais (IPVO) e a Escala de Clima Organizacional (ECO). Após análise de dados, foram identificados os valores organizacionais de colaboradores e gestores em duas percepções distintas, o que sugere que há fatores divergentes na concepção desses valores. Com efeito, é relevante ressaltar a necessidade de alinhar tais concepções para fortalecimento da cultura organizacional.

ORGANIZATIONAL PSYCHOLOGY: ORGANIZATIONAL CULTURE REVIEW AT A GYM

ABSTRACT
The organizational identity of a company comprises vision, mission, and values, through that set of principles the company provides its employees the reason to exist and where they aim to go. Organizational values are approaches the organizational reality and may be chosen during the creation of the company or even along its trajectory, being influenced either by founders and employees. Hence we see, this paper aims to identify organizational values from the administrators and employees’ views at a gym. This paper describes exploratory quantitative research using a Sociodemographic Questionnaire, Organizational Culture Profile Inventory (OCPI), and Organizational Climate Scale (OCS) as tools. After data analysis, administrators and employees’ values were identified in two different views, which suggest divergent factors in the conceptions of those values. Consequently, it is important to note the necessity to align such conceptions in order to strengthen the organizational culture.

Keywords: Organizational Culture. Organizational Psychology. Organizational Values.
LITERASI VISUAL DALAM PROSES BERKARYA MAHASISWA DESAIN
Authors: Khamadi Khamadi , Setiawan Agus 
Published: September 2020

Abstrak: Kemampuan literasi visual mahasiswa desain yang kurang menjadikan karya yang dihasilkan kurang komunikatif. Mahasiswa cenderung mengejar sisi teknis dan estetis dalam proses kreasi visualnya dan cenderung kurang menguasai konsep komunikasi pesan yang ingin disampaikan. Hal ini terjadi akibat karena kurangnya pemahaman terhadap proses literasi visual. Melalui model literasi visual oleh Hattwigg, dkk yang membagi literasi visual dalam tujuh komponen kemampuan literasi, fenomena literasi visual mahasiswa desain saat ini akan dianalisis untuk mendapatkan gambaran dan strategi penguatan kemampuan literasi visual selanjutnya. Sebagai hasilnya, mahasiswa desain masih kesulitan dalam menelusuri informasi visual dan menggunakan image visual yang ada dalam menghasilkan karya visual yang bermakna.
Kata Kunci: Desain, Kreasi Visual, Literasi Visual

Abstract: The lack of visual literacy skills of design students makes the resulting work less communicative. Students tend to pursue the technical and aesthetic side in the process of visual creation and tend to lack the mastery of the concept of communication of the message to be conveyed. This happens due to a lack of understanding of the visual literacy process. Through the visual literacy model by Hattwigg, et al., Who shares visual literacy in seven components of literacy ability, the phenomenon of visual literacy of current design students will be analyzed to obtain an overview and strategy for strengthening visual literacy skills further. As a result, design students still have difficulties in tracing visual information and using existing visual images in producing meaningful visual works.
Keywords: Design, Visual Creation, Visual Literacy
Analysis of morbidity and mortality of cervical cancer in Zabaikalskii krai
Authors: Bogomazova Tatyana V. , Chimitdorzhieva Tatyana N. 
Published: September 2020

Relevance. Currently, noncommunicable diseases are responsible for the majority of deaths worldwide. Cervical cancer (СС) is actual medical and social problem. Comparative analysis of morbidity, mortality and state of oncological care in Zabaikalskii krai and Russian Federation was purpose of this study.
Aim. Estimation of morbidity and mortality from cervical cancer in the Zabaikalskii krai in dynamics over 10 years.
Materials and methods. The assessment was carried out on the basis of an analysis of statistical data concerning the burden of morbidity and mortality from cancer in the territory of the Zabaikalskii krai and the Russian Federation. Statistical analysis was performed using the Statistica 10 software. Standardized indicators were used to analyze morbidity and mortality. Differences were considered statistically significant at an error level of p0.05.
Results. Analysis cervical cancer incidence of the Zabaikalskii krai and the Russian Federation in dynamics from 20072017 (100 000 female population) demonstrates a significant increase in the incidence of cervical cancer. On the territory of the Russian Federation, there is a steady increase on average by 2.26% annually, the growth dynamics over this period amounted to 25.81%, and in 2017 amounted to 15.76. In the Zabaikalskii krai in 2017, the incidence of cervical cancer was 41.54. In dynamics over the past 10 years, this indicator increased by 46.42%, which is significantly higher than in the Russian Federation (p0.01). The analysis of standardized indicators of mortality from cervical cancer in the structure of mortality from cancer in Russia in 2017 amounted to 5.18%, which corresponds to 10th place. Mortality in the first year since diagnosis was 14.6%. In the group of women of reproductive age 3039 years, mortality from cervical cancer was also maximum (23.6%) compared with other age groups. Mortality from cervical cancer in the Zabaikalskii krai was 7.17 in 2017. This indicator is higher than the all-Russian values by 38.41% (p0.01). In dynamics over 10 years, a decrease in mortality in the Zabaikalskii krai by 6.39% is noted.
Conclusion. It should be noted that a significant increase in the incidence of cervical cancer, and a decrease in mortality from this pathology, may indicate some success in the diagnosis and treatment of this pathology. In this regard, the search for new diagnostic, prognostic and predictive markers at this stage is relevant in solving this all-Russian medical and social problem.