bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Socratic Irony and Romantic Irony in Khayyam, Abol-ala and Schopenhauer’s Quatrains
Authors: Khalilollahi Shahla , Mousavi Maryam 
Published: March 2020

In this article we are determined to review Socratic irony, romantic and ironic structures of Khayyam's quatrains and the ones attributed to him and explain the place of Khayyam as an ironist among other thinkers of the world, according to the meaning of romantic irony and Socratic irony in his quatrains. Irony is the recognition of the fact that the world itself is sick and only an ambivalent attitude can understand its paradoxical totality. Ashleh Goal believes that irony in this sense, according to its nature, is not moderating, but it means that it is endless and self-looking like Socratic wisdom. Irony is related to an aspect of speech in which the meaning of the word is placed in contrast to the literal meaning of the word. In fact, an individual mentions something which is not what he or she actually meant, or is not all of what he or she meant. Examples of these meanings can be seen in Socrates' dialogues, which one type of irony is called Socratic irony and the other type is romantic irony. This term was used in a more complicated meaning, which was our purpose in this article, by the German romantic theorists in the late eighteenth century A.D. In romantic irony, the offended artist of the events of life portrays an excerpt from reality, from the perspective of his knowledge as Khayyam created a school and after him a number of Iran's poets continued it. He constantly reminds the human suffering by offering images of the world inversion.
IUBMB/PSBMB 2019 Conference/Plenary: National Program Accreditation. Does it help drive change and support faculty and student or does it limit our creativity?
Authors: Provost Joseph J. 
Published: March 2020

AbstractAccreditation of academic programs and recognition of student degrees provide academic institutions a measure of a set of community agreed upon standards. These can aid pedagogical change, support faculty to successfully engage students in their discipline and to provide a mechanism to maintain standards. Several professional scientific societies from engineering, chemistry, and biochemistry and molecular biology have developed standards by which departments can be recognized for accreditation. As one of the members of the American Society for Biochemistry and Molecular Biology who helped develop the accreditation and standardized exams and a committee member of the American Chemical Society's Committee on Professional Training I will present the evolution of the accreditation process, discuss the benefits and challenges with being an accreditation. How these programs serve their communities and at times can hinder or be used to support potential creativity and teaching pedagogies will also be discussed.
Circular economy to enhance sustainability of small and medium‐sized enterprises
Authors: Dey Prasanta Kumar , Malesios Chrisovaladis , De Debashree , Budhwar Pawan , Chowdhury Soumyadeb , Cheffi Walid 
Published: March 2020

AbstractThe circular economy (CE) represents a major paradigm shift of moving from the concepts of linear to circular supply chains across multiple industries. Although some aspects of CE adoption within industrial supply chains have been researched extensively (particularly addressing challenges of design, implementation, and operations), the research that relates CE practices with sustainability performance to reveal the current state of CE practices within small and medium‐sized enterprises (SMEs) is scant. The aim of this research was to facilitate SMEs to achieve greater sustainability through CE implementation. This research addresses three research questions—How are CE fields of action related to sustainability performance? What are the issues, challenges, and opportunities of adopting CE in SMEs? And what key strategies, resources, and competences facilitate effective implementation of CE in SMEs? This study adopts a mixed method approach (qualitative and quantitative) using survey research, focus group, and case studies; 130 randomly selected SMEs within the Midlands of the United Kingdom have been surveyed, and the responses are analysed using statistical tools along with findings from focus groups and case studies. The study reveals that all CE fields of action (take, make, distribute, use, and recover) of SMEs are correlated to economic performance, but only make and use are related to environmental and social performance. The study further derives strategies, resources, and competences for achieving sustainability across all the CE field of actions. Additionally, this research reveals the issues and challenges, strategies, resources, and competences required for implementing CE in SMEs.
TSPAN31 suppresses cell proliferation in human cervical cancer through down‐regulation of its antisense pairing with CDK4
Authors: Xia Yingjie , Deng Yuanfei , Zhou Yuting , Li Dan , Sun Xuemeng , Gu Lei , Chen Zipeng , Zhao Qing 
Published: March 2020

Natural antisense transcripts (NAT) are prevalent phenomena in the mammalian genome and play significant regulatory roles in gene expression. While new insights into NAT continue to be revealed, their exact function and their underlying mechanisms in human cancer remain largely unclear. We identified a NAT of CDK4, referred to TSPAN31, which inhibits CDK4 mRNA and protein expression in human cervical cancer by targeting the 3′‐untranslated region (3′‐UTR) of the CDK4 mRNA. Furthermore, silencing the expression of the TSPAN31 mRNA rescued the TSPAN31 3′‐UTR‐ or the TSPAN31 full‐length‐induced decrease in CDK4 expression. Noteworthy, we discovered that TSPAN31, as a member of the tetraspanin family, suppressed cell proliferation by down‐regulating its antisense pairing with CDK4 and decreasing retinoblastoma protein phosphorylation in human cervical cancer. Therefore, the results of the present study suggest that TSPAN31 may serve as a potential molecular target for the development of novel anti‐cancer agents.Significance of the studyNatural antisense transcripts are widely found in the genome and play an important role in the growth and development of cells. TSPAN31 is natural antisense transcript, and CDK4 is an important gene in the regulation of the cell cycle. Therefore, TSPAN31 and CDK4 have great significance in the study of tumour therapeutic targets.
Efficient Separation of Photogenerated Charges in Sandwiched Bi2S3−BiOCl Nanoarrays/BiVO4 Nanosheets Composites for Enhanced Photocatalytic Activity
Authors: Li Huali , Chen Yajie , Li Li , Liu He , Jiang Haiyu , Du Lizhi , Tian Guohui 
Published: March 2020

AbstractThe development of cost‐efficient and feasible strategies for producing efficient photocatalysts is crucial to advance photocatalytic pollutants degradation. Herein, we report a high photocatalytic active hierarchical sandwiched Bi2S3−BiOCl nanoarrays/BiVO4 nanosheets composites fabricated using biomass‐derived BiVO4 porous nanosheets as starting substrate material. BiVO4 porous nanosheets were first prepared via an impregnation‐calcination process using biomass template method. Subsequently, the ion exchange reactions during solvothermal reaction realized the in situ nucleation and growth of Bi2S3 nanorods and BiOCl nanoflakes nanoarrays from both sides of BiVO4 porous nanosheets, resulting in the formation of hierarchical sandwiched Bi2S3−BiOCl nanoarrays/BiVO4 nanosheets composites. Specifically, well‐defined Bi2S3 nanorods and BiOCl nanoflakes nanoarrays are vertically grown on the surface of BiVO4 nanosheets to provide plenty of accessible active sites and enable visible light harvesting. The tight contact between different components promises fast electron transfer and excellent durability. Consequently, optimized sandwiched Bi2S3−BiOCl/BiVO4 composite exhibits superior photocatalytic activity for pollutants degradation.
Electronic Modulation between Tungsten Nitride and Cobalt Dopants for Enhanced Hydrogen Evolution Reaction at a Wide Range of pH
Authors: Liu Zhizhong , Zhang Xuming , Song Hao , Yang Yixuan , Zheng Yang , Gao Biao , Fu Jijiang , Chu Paul K. , Huo Kaifu 
Published: March 2020

AbstractTransition metal nitrides with Pt‐like chemical properties are important electrocatalysts and tungsten nitride (WN) is a good hydrodenitrogenation and hydrodesulfurization catalyst but its catalytic activity for hydrogen evolution reaction (HER) is poor because of the unfavourable d‐band electronic structure resulting in strong interactions with adsorbed hydrogen. Herein, Co doped WN nanowire arrays grown on carbon cloth are reported and the result shows that Co dopants not only act as active sites, but also increase activity of W sites by downshifting the position of d‐band centre of W sites as a result of the electron transfer from W to Co. Density‐functional theory (DFT) and density of states (DOS) calculations confirm that the enhanced HER performance is attributed to the modulation of the d‐band center of W and introduced Co dopants both consequently facilitating the HER process. The results on electronic modulation provide insights into the design of electrocatalysts with high activity.
Infigratinib in upper tract urothelial carcinoma versus urothelial carcinoma of the bladder and its association with comprehensive genomic profiling and/or cell‐free DNA results
Authors: Pal Sumanta K. , Bajorin Dean , Dizman Nazli , Hoffman‐Censits Jean , Quinn David I. , Petrylak Daniel P. , Galsky Matthew D. , Vaishampayan Ulka , De Giorgi Ugo , Gupta Sumati , Burris Howard A. , Soifer Harris S. , Li Gary , Wang Hao , Dambkowski Carl L. , Moran Susan , Daneshmand Siamak , Rosenberg Jonathan E. 
Published: March 2020

BackgroundInfigratinib (BGJ398) is a potent and selective fibroblast grown factor receptor 1 to 3 (FGFR1‐3) inhibitor with significant activity in patients with advanced or metastatic urothelial carcinoma bearing FGFR3 alterations. Given the distinct biologic characteristics of upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB), the authors examined whether infigratinib had varying activity in these settings.MethodsEligible patients had metastatic urothelial carcinoma with activating FGFR3 mutations and/or fusions. Comprehensive genomic profiling was performed on formalin‐fixed, paraffin‐embedded tissues. Blood was collected for cell‐free DNA analysis using a 600‐gene panel. Patients received infigratinib at a dose of 125 mg orally daily (3 weeks on/1 week off) until disease progression or intolerable toxicity occurred. The overall response rate (ORR; partial response [PR] plus complete response [CR]) and disease control rate (DCR; CR plus PR plus stable disease [SD]) were characterized.ResultsA total of 67 patients were enrolled; the majority (70.1%) had received ≥2 prior antineoplastic therapies. In 8 patients with UTUC, 1 CR and 3 PRs were observed (ORR, 50%); the remaining patients achieved a best response of SD (DCR, 100%). In patients with UCB, 13 PRs were observed (ORR, 22%), and 22 patients had a best response of SD (DCR, 59.3%). Notable differences in genomic alterations between patients with UTUC and those with UCB included higher frequencies of FGFR3‐TACC3 fusions (12.5% vs 6.8%) and FGFR3 R248C mutations (50% vs 11.9%), and a lower frequency of FGFR3 S249C mutations (37.5% vs 59.3%).ConclusionsDifferences in the cumulative genomic profile were observed between patients with UTUC and those with UCB in the current FGFR3‐restricted experience, underscoring the distinct biology of these diseases. These results support a planned phase 3 adjuvant study predominantly performed in this population.
A malware detection method using satisfiability modulo theory model checking for the programmable logic controller system
Authors: Xie Yaobin , Chang Rui , Jiang Liehui 
Published: March 2020

SummaryNowadays programmable logic controllers (PLCs) are suffering increasing cyberattacks. Attackers could reprogram PLCs to inject malware that would cause physical damages and economic losses. These PLC malwares are highly customized for the target which makes it difficult to extract a general pattern to detect them. In this article, we propose a PLC malware detection method based on model checking. Firstly, we improve the existing modeling method for PLC system by using the Satisfiability Modulo Theory (SMT) constraints to model the PLC system. We also present an algorithm that can transform the PLC program to the model. Our SMT‐based model can deal with the features of the PLC system such as undetermined input signals, edge detection and so on. Secondly, we focus on malware detection and propose two methods, invariant extraction and rule design pattern, to generate detection rules. The former can extract the invariants from an original program, and the latter can lower the bar for user to design detection rules. Finally, we implement a prototype and evaluate it on three representative ICS scenarios. The evaluation result shows that our proposed method can successfully detect the malwares using four attack patterns.
All‐Solid‐State Lithium–Organic Batteries Comprising Single‐Ion Polymer Nanoparticle Electrolytes
Authors: Kim Boram , Kang Haneol , Kim Kyoungwook , Wang Rui‐Yang , Park Moon Jeong 
Published: March 2020

AbstractAdvances in lithium battery technologies necessitate improved energy densities, long cycle lives, fast charging, safe operation, and environmentally friendly components. This study concerns lithium–organic batteries comprising bioinspired poly(4‐vinyl catechol) (P4VC) cathode materials and single‐ion conducting polymer nanoparticle electrolytes. The controlled synthesis of P4VC results in a two‐step redox reaction with voltage plateaus at around 3.1 and 3.5 V, as well as a high initial specific capacity of 352 mAh g−1. The use of single‐ion nanoparticle electrolytes enables high electrochemical stabilities up to 5.5 V, a high lithium transference number of 0.99, high ionic conductivities, ranging from 0.2×10−3 to 10−3 S cm−1, and stable storage moduli of >10 MPa at 25–90 °C. Lithium cells can deliver 165 mAh g−1 at 39.7 mA g−1 for 100 cycles and stable specific capacities of >100 mAh g−1 at a high current density of 794 mA g−1 for 500 cycles. As the first successful demonstration of solid‐state single‐ion polymer electrolytes in environmentally benign and cost‐effective lithium–organic batteries, this work establishes a future research avenue for advancing lithium battery technologies.
Medication management through pharmacist‐provided home‐based services
Authors: Pherson Emily , Swarthout Meghan , Fu Denise , Barbour Lauren , Green Robert , Ross Patricia , Nesbit Todd 
Published: March 2020

AbstractIntroductionPharmacists play an important role in helping patients manage their medications across the continuum of care. Pharmacist home visits support continuity of care and provide a unique opportunity to identify medication‐related problems.ObjectiveThe primary objective of this study was to describe a cohort of patients who received home visits and the subsequent actions taken by the pharmacist towards the goal of optimizing medication regimens. The evolution of the service is also described.MethodsA retrospective chart review was used to gather demographic information. Clinical documentation was reviewed to gather information on medication problems identified by the pharmacist and recommendations made to prescribers. Institutional and city databases were used to collect data on readmissions and socioeconomic status, respectively. Descriptive statistics were used to analyze data.ResultsBetween February 2012 and December 2018, 485 home visits were conducted. Patients were taking a mean of 13 (SD ±5.5) medications; 1890 medication discrepancies were identified and 862 recommendations were made to prescribers. The relative risk reduction in readmissions for those patients who received a home visit was 6.6%. The average yearly income for citizens who live in neighborhoods where many of the home visits took place was $37 000. Details regarding the evolution of the home visit service were described.ConclusionsA large cohort of 485 home visits demonstrated that medications are often not being taken as prescribed, and that the pharmacist is in a unique position to educate patients and work with providers toward the goal of optimizing medication regimens and behaviors. This model of care, focused on high‐risk patients, has been sustained over 7 years. Ongoing efforts are underway to improve communication with prescribers, increase the referral to home visit conversion rate, and enhance longitudinal outcome tracking. Opportunity exists to further expand the service through partnerships with regional payers.
Exploring anomalous behaviour detection and classification for insider threat identification
Authors: Le Duc C. , Zincir‐Heywood Nur 
Published: March 2020

SummaryRecently, malicious insider threats represent one of the most damaging threats to companies and government agencies. Insider threat detection is a highly skewed data analysis problem, where the huge class imbalance makes the adaptation of learning algorithms to the real‐world context very difficult. This study proposes a new system for user‐centred machine learning‐based anomaly behaviour and insider threat detection on multiple data granularity levels. System evaluations and analysis are performed not only on individual data instances but also on normal and malicious users. Our results show that the proposed system, which is a combination of unsupervised anomaly detection and supervised machine learning methods, can learn from unlabelled data and a very small amount of labelled data. Furthermore, it can generalize to bigger datasets for detecting anomalous behaviours and unseen malicious insiders with a high detection and a low false‐positive rate.
Interfacial Synthesis of a Monolayered Fluorescent Two‐Dimensional Polymer through Dynamic Imine Chemistry
Authors: Zhang Zhaohui , Liu Hui , Sun Qingzhu , Shao Feng , Pan Qingyan , Zhuang Tao , Zhao Yingjie 
Published: March 2020

AbstractA fluorescent monolayered two‐dimensional polymer (2DP) containing both tetraphenylethylene (TPE) and imine linkages is synthesized at air‐water interface using the Langmuir‐Blodgett method. We designed TPE‐based monomers with long distances between the TPE and the imine linkages to avoid the charge transfer and therefore keep the fluorescence. A monolayered 2DP provided with more than 104 μm2 in domain size and around 0.8 nm thickness was obtained through a successive Schiff base reaction at air‐water interface. The nanostructures and fluorescent property of 2DP films were characterized by optical microscopy, SEM, TEM, AFM and fluorescence spectrum. Most importantly, the tip‐enhanced Raman spectroscopy (TERS) was utilized here to confirm the success of the polycondensation of monolayered 2DP.
Identifying the tacit entrepreneurial opportunity of latent customer needs in an emerging economy: The effects of experiential market learning versus vicarious market learning
Authors: Bao Yongchuan , Wei Zelong , Di Benedetto Anthony 
Published: March 2020

AbstractResearch SummaryFocusing on latent customer needs as the essential substance of entrepreneurial opportunities, this study examines the determinants of the identification of such opportunities. Based on organizational learning theory, we explore the effects of experiential market learning (EML) and vicarious market learning (VML), and the contingency of such effects on different dimensions of environmental uncertainty in an emerging economy: demand uncertainty of the task environment and legal inefficiency of the institutional environment. The model was tested through survey among 238 firms in China. We find that both EML and VML facilitate the identification of latent customer needs, while they interact with environmental uncertainty in different ways. This study makes substantial contributions to the extant literature on opportunity identification, strategic entrepreneurship, and the origin of entrepreneurial opportunities.Managerial SummaryLatent customer needs, which customers are not aware of or unable to articulate, serve as a catalyst for firm growth and are integral to the business model design. How can firms identify such essential entrepreneurial opportunities? We investigate this question in an emerging economy in which latent needs are more frequently encountered and find that both learning from direct market experience (EML) and learning from other firms' market experience (VML) increase the likelihood of identifying latent needs, while VML is more influential than EML. Facing high demand uncertainty, firms should rely more on VML than EML to identify latent needs, whereas in an uncertain institutional environment with a weak legal system, firms should place less emphasis on VML and more on EML in the identification of latent needs.
Dynamic and Kinetic Parameters and Energy Exchanges of Particles in Reaction of NH + OH and Deuterated Analogues on an Interpolated Potential Energy Surface
Authors: Sharafdini Raziyeh , Ramazani Shapour 
Published: March 2020

AbstractIn this research, we reported an interpolated potential energy surface (PES) from ab initio electronic energy of molecular fragments for NH + OH reaction and isotopic substitution. Classical trajectory simulations were performed on this surface to determine reaction probabilities and reaction cross sections in various channels. Also, reaction probability and reaction cross section as a function of the translation energy of fragments were shown. For inelastic collision, the conversion of kinetic energy of particles into internal energy or kinetic energy of another particle was studied. The effect of the impact parameter and relative translational energy of particles on the deflection angle was also investigated. Nonlinear least squares fitting was applied to compute rate constants expressions and these were computed as a function of the cross section. Deuterium was used instead of the hydrogen atom to investigate the effect of the mass of the target molecule and incident molecule on the cross section, reaction probability, scattering angle, and reaction rate.
Efficient and Uncatalyzed Synthesis of Highly Functionalized New Symmetrical Indeno[1,2‐b]pyrroles via a One‐Pot Four‐Component Reaction
Authors: Rezvanian Atieh , Mahmoodi Fahame , Zadsirjan Vahideh , Salimi Mehri , Heravi Majid M. 
Published: March 2020

AbstractA facile, efficient and un‐catalyzed approach for the synthesis of new symmetrical highly‐ substituted indeno [1,2‐b]pyrrole derivatives through four‐component reaction, involving, primary amines, diamine, diketene, and ninhydrin in CH2Cl2 at ambient temperature is reported. This approach enjoys merits such as being done in the absence of catalyst at ambient temperature, giving good to excellent yields, completed in short reaction times, and showing a wide functional group tolerance.