bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic Prediction of Complex Traits with Iterative Screen Regression Models
Authors: Luo Meng , Gu Shiliang 
Published: November 2020

AbstractAlthough genome-wide association studies have successfully identified thousands of markers associated with various complex traits and diseases, our ability to predict such phenotypes remains limited. A perhaps ignored explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. However, using genotype data for individuals to perform accurate genetic prediction of complex traits can promote genomic selection in animal and plant breeding and can lead to the development of personalized medicine in humans. Because most complex traits have a polygenic architecture, accurate genetic prediction often requires modeling genetic variants together via polygenic methods. Here, we also utilize our proposed polygenic methods, which refer to as the iterative screen regression model (ISR) for genome prediction. We compared ISR with several commonly used prediction methods with simulations. We further applied ISR to predicting 15 traits, including the five species of cattle, rice, wheat, maize, and mice. The results of the study indicate that the ISR method performs well than several commonly used polygenic methods and stability.
Complete Genome Sequences of Nine Cluster A Mycobacteriophages: AgentM, Ajay, Aragog, Archetta, ForGetIt, Koko, Ph8s, Phlorence, and Wilkins
Authors: Lipman Rachel M. , Freise Amanda C. , Kapinos Andrew , Torres Canela , Reddi Krisanavane , Parker Jordan Moberg 
Published: November 2020

AbstractBackgroundBacteriophages are ubiquitous, highly diverse, and relatively understudied. Growing interest in phage therapy has underscored the importance of isolating and characterizing novel bacteriophages. The Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) program aims to address this need by involving undergraduates around the world in authentic research.Materials and MethodsNine novel mycobacteriophages - AgentM, Ajay, Aragog, Archetta, ForGetIt, Koko, Ph8s, Phlorence, and Wilkins - were isolated from soil samples in southern California using hostMycobacterium smegmatismc2155. Each purified phage was characterized using transmission electron microscopy and genome sequencing and annotation.ResultsAll nine bacteriophages were placed into mycobacteriophage Cluster A based on nucleotide similarity with other phages. The average genome length of all nine phages was 50,706 bp. On average, each phage had 87 total coding genes and GC content between 60-63%, consistent with that of other Cluster A phages. Transmission electron microscopy of phage particles revealed they had icosahedral heads and long, flexible tails, consistent with that of theSiphoviridaefamily. Plaque morphology and genome analysis confirms the nine novel phages are temperate as expected of Cluster A phages.ConclusionsAgentM, Ajay, Aragog, Archetta, ForGetIt, Koko, Ph8s, Phlorence, and Wilkins are all mycobacteriophages that belong to theSiphoviridaefamily. Comparative genomic analyses revealed genetic mosaicism and diversity among these Cluster A phages. The discovery of these novel phages expands on the existing library of mycobacteriophage genomes.
Discovering a less-is-more effect to select transcription factor binding sites informative for motif inference
Authors: Xu Jinrui , Gao Jiahao , Gerstein Mark 
Published: November 2020

ABSTRACTMany statistical methods have been developed to infer the binding motifs of a transcription factor (TF) from a subset of its numerous binding regions in the genome. We refer to such regions, e.g. detected by ChIP-seq, as binding sites. The sites with strong binding signals are selected for motif inference. However, binding signals do not necessarily indicate the existence of target motifs. Moreover, even strong binding signals can be spurious due to experimental artifacts. Here, we observe that such uninformative sites without target motifs tend to be “crowded” -- i.e. have many other TF binding sites present nearby. In addition, we find that even if a crowded site contains recognizable target motifs, it can still be uninformative for motif inference due to the presence of interfering motifs from other TFs. We propose using less crowded and shorter binding sites in motif interference and develop specific recommendations for carrying this out. We find our recommendations substantially improve the resulting motifs in various contexts by 30%-70%, implying a “less-is-more” effect.
Augmenter of Liver Regeneration Regulates Cellular Iron Homeostasis by Modulating Mitochondrial Transport of ATP-Binding Cassette B8
Authors: Chang Hsiang-Chun , Shapiro Jason S. , Jiang Xinghang , Senyei Grant , Sato Teruki , Sawicki Konrad T. , Ardehali Hossein 
Published: November 2020

AbstractChronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts, however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S cluster biogenesis in mammalian cells. Mechanistically, MIA40/ALR facilitates the mitochondrial import of ATP binding cassette (ABC)-B8, an inner mitochondrial membrane protein required for cytoplasmic Fe/S cluster maturation, through physical interaction with ABCB8. Downregulation of ALR impairs mitochondrial ABCB8 import, reduces cytoplasmic Fe/S cluster maturation, and increases cellular iron through the iron regulatory protein-iron response element system. Our finding provides a mechanistic link between MIA40/ALR import machinery and cytosolic Fe/S cluster maturation through the mitochondrial import of ABCB8, and offers a potential explanation for the pathology seen in patients with ALR mutations.
Propeller locations study of a generic delta wing UAV model
Authors: Kasim Khushairi Amri , Mat Shabudin , Ishak Iskandar Shah , Mansor Shuhaimi 
Published: November 2020

Purpose
This study aims to investigate the effects of propeller locations on the aerodynamic characteristics of a generic 55° swept angle sharp-edged delta wing unmanned aerial vehicle (UAV) model.

Design/methodology/approach
A generic delta-winged UAV model has been designed and fabricated to investigate the aerodynamic properties of the model when the propeller is placed at three different locations. In this research, the propeller has been placed at three different positions on the wing, namely, front, middle and rear. The experiments were conducted in a closed-circuit low-speed wind tunnel at speeds of 20 and 25 m/s corresponding to 0.6 × 106 and 0.8 × 106 Reynolds numbers, respectively. The propeller speed was set at constant 6,000 RPM and the angles of attack were varied from 0° to 20° for all cases. During the experiment, two measurement techniques were used on the wing, which were the steady balance measurement and surface pressure measurement.

Findings
The results show that the locations of the propeller have significant influence on the lift, drag and pitching moment of the UAV. Another important observation obtained from this study is that the location of the propeller can affect the development of the vortex and vortex breakdown. The results also show that the propeller advance ratio can also influence the characteristics of the primary vortex developed on the wing. Another main observation was that the size of the primary vortex decreases if the propeller advance ratio is increased.

Practical implications
There are various forms of UAVs, one of them is in the delta-shaped planform. The data obtained from this experiment can be used to understand the aerodynamic properties and best propeller locations for the similar UAV aircrafts.

Originality/value
To the best of the author’s knowledge, the surface pressure data available for a non-slender delta-shaped UAV model is limited. The data presented in this paper would provide a better insight into the flow characteristics of generic delta winged UAV at three different propeller locations.
Personalized coupons for lower-calorie fast-food choices among young German adults and the influence of consumers' nutritional attitudes on promotion effectiveness
Authors: Nguyen Minh Thi Thuy , Emberger-Klein Agnes , Menrad Klaus 
Published: November 2020

PurposePersonalized price promotion (PPP) is a marketing instrument that addresses the limitations of untargeted promotions by tailoring the offers to individual customers based on their purchase histories. Current evidence on PPP is limited to its immediate effects on buying behaviors at grocery stores and food companies' economic benefits. Moreover, little is known about the role of consumer characteristics in determining how effectively this promotional tool works. Hence, we aim to assess the effectiveness of PPP in promoting healthy fast food and which consumer-specific factors affect its performance.Design/methodology/approachThe authors conduct a laboratory experiment to examine the effects of personalized and non-personalized coupons for lower-calorie fast food menus on food and calorie selection. The coupon personalization is based on participants' menu choices, calorie needs and deal proneness. The authors additionally investigate how post-intervention changes are influenced by consumers' estimation of their selected calories, and their attitudes toward nutrition.FindingsRecipients of personalized incentives are more likely than participants in the control group to redeem the offered coupons, select more healthy items and reduce their selected calories. Such changes are less likely among participants underestimating the calorie content of their menu choices and perceiving higher barriers to healthy eating. Personalized coupons perform better even among subjects receiving lower discounting levels than the control treatment.Originality/valueAs the first to evaluate the effectiveness of PPP in encouraging healthy food choices, this study highlights the potential of this cutting-edge price intervention and provides valuable implications for future research.
An integrated ANP–QFD approach for prioritization of customer and design requirements for digitalization in an electronic supply chain
Authors: TS Deepu , V Ravi 
Published: November 2020

PurposeSupply chain efficiency can be enhanced by integrating the activities in supply chain through digitalization. Advancements in digital technologies has facilitated in designing robust and dynamic supply chain by bringing in efficiency, transparency and reduction in lead times. This research tries to identify and prioritize the customer requirements and design requirements for effective integration of supply chain through digitalization.Design/methodology/approachThe key nine customer requirements and 16 design requirements applicable for an electronics company were shortlisted in consultation with the experts from the company and academia. An integrated analytic network process (ANP) and quality function deployment (QFD) methodology has been applied for prioritizing the customer and design requirements. The relative importance and interdependence of these requirements were identified and a House of Quality (HOQ) is constructed.FindingsThe HOQ constructed has prioritized and identified interrelationships among customer requirements and design requirements for effective supply chain digitalization. These findings could be effectively used by managers for planning the objectives on long-term, medium-term and short-term basis.Originality/valueThis study tries to bridge the gap of identifying and prioritizing the design and customer requirements for effective supply chain integration through digitalization. The results could aid practicing managers and academicians in decision-making on supply chain digitalization process.
Exploring potential implications of Belt and Road Initiative for supply chain resilience: a comparative study of five South Asian countries
Authors: Butt Atif Saleem , Shah Syed Hamad Hassan 
Published: November 2020

PurposeThis paper explores the potential opportunities and challenges that Belt and Road Initiative (BRI) may bring for resilient supply chains.Design/methodology/approachThis study employs multiple case study methodology by considering five south Asian countries. Overall, 36 semi-structured interviews with supply chain managers from three supplying firms, two transportation centers and four buying firms are undertaken. Three supplying firms were based in Pakistan, providing cement and steel products. Simultaneously, two transportation centers were located in Sri Lanka and Bangladesh, mainly engaged in cargo and freight handling. Finally, the buying firms were located in Mainland China and India, mainly constructing road and rail networks.FindingsOur findings reveal both challenges and opportunities for supply chain resilience within the context of BRI. In particular, findings suggest that BRI can improve quality infrastructure, greater connectivity for logistics firms and enhance consumer markets. Conversely, BRI also poses challenges to supply chain resilience in managing large-scale logistics infrastructure and the potential conflicts between countries participating in BRI.Research limitations/implicationsAs this study attempts to build a theory, its result should not be generalized to a broader population. Second, this study only explores BRI's implications for resilient supply chains within five South Asian countries.Practical implicationsFirms can use our study results to understand BRI’s implications for resilient supply chains. Particularly, it presents firms with the potential opportunities and challenges that BRI brings for resilient supply chains.Originality/valueBRI has been the subject of much research in domains like political science, economics and law but its application to the supply chain resilience is rather scant. Our study, therefore, contributes to the emergent literature on supply chain resilience within the context of BRI by exploring its potential opportunities and challenges.
Uncovering the dimensions of servicescape using mixed method approach – A study of beauty salons
Authors: Kampani Nidhi , Jhamb Deepika 
Published: November 2020

PurposeThe purpose of this study aims to explore the dimensions assessing the servicescape of beauty salons and provides suggestions to improve the salon's servicescape.Design/methodology/approachA mixed-method design is used in the sequence of thematic analysis through focus group technique followed by exploratory factor analysis and confirmatory factor analysis were used to assess the beauty salon's servicescape.FindingsThe exploration of factors in beauty salons is determined with three dimensions: the substantive staging of servicescape, the communicative staging of servicescape and the social staging of servicescape. These dimensions are mentioned in the order of importance perceived by the customers. The substantive staging of servicescape was identified with five factors: ambient conditions, facility aesthetics, artifacts, provisions and spatial layout. Communicative staging of servicescape explored four factors: employee duties, employee commitment, employee–customer interactions and employee image. Social staging derived two factors: customer characteristics, customer-to-customer interactions.Research limitations/implicationsThe findings enrich the previous literature with the addition of new factors while assessing servicescape in beauty salons and the development of new items through qualitative research in the domain of servicescape.Practical implicationsThe study offers the managers to understand the importance of various factors affecting the servicescape in beauty salons. The salon managers can beautify the service environment through the implementation of the factors identified, thus resulting in enhancing the experience of customers at the salons.Originality/valueConsidering no research has been conducted on beauty salons scale development, this study serves as the first empirical research effort.
Embedding entrepreneurship in doctoral students: the impact of a T-shaped educational approach
Authors: Rippa Pierluigi , Landi Giovanni , Cosimato Silvia , Turriziani Lorenzo , Gheith Mohamed 
Published: November 2020

PurposeOver the last decades, the importance of entrepreneurial education (EE) for the personal development of young generations has gained momentum among policymakers, practitioners and scholars. This paper offers some insights into the way T-shaped PhD programs can trigger transdisciplinary abilities of STEM students, making them even more ready toward venturing activities.Design/methodology/approachTo achieve the purpose of the study, the effectiveness of a new T-shaped doctoral model was explored, testing it on a sample of STEM PhD students at Polytechnic School of University of Naples Federico II, using a qualitative-quantitative approach.FindingsThe results prove the positive influence that the T-shaped PhD program has on students in terms of vertical skills and horizontal capabilities attainment for entrepreneurial readiness.Practical implicationsThis study advances interesting managerial and policy implications for activating virtuous collaborations to better respond to the need of current socioeconomic scenarios through academic knowledge.Originality/valueDespite the growing relevance of EE, research about its influence at PhD level and the effect of different pedagogical methods remains scarce and controversial. Thus, this research explores if EE can support PhD students in science and technology transdisciplinarity terms of innovation management.
Authentic leadership and organizational citizenship behaviour: the role of psychological capital
Authors: Sri Ramalu Subramaniam , Janadari Nadira 
Published: November 2020

PurposeThe purpose of this paper is to examine the direct and indirect effects of authentic leadership on organizational citizenship behaviour (OCB) with the presence of psychological capital as a mediating factor.Design/methodology/approachThis quantitative research was conducted among 396 front-line employees in six public sector organizations in Sri Lanka. A survey method was employed to collect the data.FindingsIt was found that psychological capital partially mediates the relationship between authentic leadership and OCB. In other words, the relationship between authentic leadership and OCB is both direct and indirect, mediated though psychological capital.Research limitations/implicationsThe authenticity of leaders' conduct, psychological capabilities and the outcomes of the performance, are rooted in and reinforced by the culture of the particular organization; hence, the findings should be interpreted cautiously.Practical implicationsThe framework of the present study provides a guideline to the top management of the public sector in Sri Lanka to design leadership programs that can develop authentic leaders.Originality/valueThe direct and indirect relationships established between authentic leadership and psychological capital and OCB signifies the critical importance of authentic leadership in the development of psychological capital and OCB among employees.
Decent work and work–family enrichment: role of meaning at work and work engagement
Authors: Kashyap Vaneet , Arora Ridhi 
Published: November 2020

PurposeThe purpose of the current study is to examine decent work (DW) as a critical antecedent of work–family enrichment (WFE). Further, it also focuses on understanding the underlying mechanisms that facilitate the linkage of employees' perceptions of DW and WFE by investigating about the mediating role of knowledge workers' experience of meaning at work and their work engagement levels.Design/methodology/approachThis study adopts a quantitative cross-sectional research design using survey administration among faculty members employed in public and private universities of North India.FindingsResults depicted that in addition to direct relationship between DW and WFE, both meaning at work and work engagement partially mediate the relationship between access to DW and WFE indirectly. These findings showed that the provision of access to DW by organizations will help facilitate WFE via employees' experience of meaning at work and their levels of engagement with their work.Practical implicationsThe study findings would be useful for organizational practitioners and policymakers to design sustainable human resource development (HRD) policies and practices for enriching the WFE of employees as well as in driving talent retention and engagement.Originality/valueIt is one of the few studies that captures perceptions of employees about access to DW policies and practices and its role in enhancing WFE in the South Asian context. Further, it also advances our knowledge on antecedents and consequences of WFE.
Student experiences studying accounting in English as an additional language
Authors: Smith Sonnette , Carstens Adelia , Stainbank Lesley 
Published: November 2020

Purpose
This paper aims to explore the individual and social learning experiences of first-year accounting students studying in English as an additional language. The challenges of these students relating to listening, reading, speaking and writing in English, and the impact of these on their academic outcomes, are examined.

Design/methodology/approach
A qualitative case study design was used. Face-to-face semi-structured interviews were conducted with 14 students, both academically successful and unsuccessful, who had completed the first year. A thematic analysis of the data was conducted and a hybrid approach of deductive and inductive coding was used to interpret the data. This entailed the application of a language skills-based framework of teaching and learning to the first-order process of coding. An iterative and reflective process allowed themes to emerge from the data. These themes, in turn, triggered second-order codes that resonated with aspects of the interactionist approach to second language acquisition (SLA).

Findings
The themes that emerged indicated that students’ ability to interact with their study material, and their exposure to positive verbal interaction opportunities in both formal and informal contexts, may have contributed to their academic success.

Practical implications
It is recommended that an interactionist perspective be considered when designing curriculum resources and accounting language learning activities for first-year accounting students.

Originality/value
It is anticipated that the results will contribute towards building a bridge between accounting education and SLA research and provide a more informed linguistic foundation for incorporating language skills into the accounting curriculum.