bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Thermal Expansion on the Bond Strength of Nanozirconia and Veneering Ceramics
Authors: Almoualimy Ahlam , Yew Hsu Zenn , Zaman Jasmina Qamaruz , Yahaya Norziha , Muchtar Andanastuti 
Published: June 2020

Abstract
This study was aimed to determine the coefficient thermal expansion (CTE) of colloidal-processed slip-casted novel nanozirconia (Zir) and to elucidate the effect of the differences in CTE values between zirconia cores and veneering porcelains on core–veneer shear bond strength (SBS). CTE measurement was performed on core materials (CMs; Zir and Cercon® [Cer]) and veneering ceramics (VCs; Ceram Kiss® [CK], VITA VM9® [VM9], and IPS e.max Ceram® [e.max]). The SBS test was conducted on six groups of core–veneer samples (Zir–CK, Zir–e.max, Zir–VM9, Cer–CK, Cer–e.max, and Cer–VM9). The mean CTE values (× 10− 6/°C ± standard deviation) of Zir and Cer were 7.86 ± 0.47 and 7.82 ± 0.49, respectively. CK, VM9, and e.max recorded mean CTE values of 7.20 ± 0.62, 7.20 ± 0.29, and 7.10 ± 0.46, respectively. No statistically significant differences were found among the CTE values of CMs and between those of VCs. Zir–VM9 recorded the highest mean SBS value (MPa) of 149.48 ± 67.64, whereas Cer–e.max produced the lowest SBS value of 44.07 ± 16.49. Combinations with high CTE disparities produced low SBS values. CTE discrepancies affected the SBS of veneered zirconia restorations. The novel zirconia showed similar performance and can be used as an alternative to commercial zirconia.
A comparative study of cyclophosphamide, thalidomide and dexamethasone (CTD) versus bortezomib and dexamethasone (BDex) in light-chain amyloidosis
Authors: Liu Baojian , Wang Yan , Ning Xiaoxuan , Bai Ming , Wang Di , Zhao Jin , Zhou Meilan , Sun Shiren 
Published: June 2020

Abstract
Background: Cyclophosphamide, thalidomide and dexamethasone (CTD) or bortezomib and dexamethasone (BDex) show substantial efficacy in patients with amyloid light-chain (AL) amyloidosis, especially in Chinese patients. Currently, both regimens are recommended as primary treatment options for AL amyloidosis, but no comparative study has been reported. Results: We retrospectively evaluated the outcomes of 81 AL patients who received CTD (n=42) or BDex (n=39) and used Mayo stage 2012 to match 26 pairs of patients. In the whole cohort, the overall hematologic responses were 86% vs 91% in the CTD and BDex groups, including a complete response of 56% vs 71% based on an intention-to-treat (ITT) analysis. One- and two-year overall survival (OS) was 90.2% and 81.7% with CTD, and 87.6% and 82.7% with BDex. After matching, BDex regimen induced a significantly deeper and more rapid hematologic response over CTD, but no statistically significant difference in OS (ITT analysis, P =0.24; 6-month landmark analysis, P =0.48). Cardiac response rates were similar, while there was a trend for higher renal responses in patients treated with BDex (68% vs 44%, P =0.09). Additionally, BDex was associated with significantly improved survival in patients with advanced disease (Mayo stage III or worse) ( P =0.009). Patients treated with BDex reported more episodes of severe hematologic toxicity and diarrhea. Conclusions: CTD and BDex are effective treatments for Chinese patients with AL amyloidosis, but BDex regimen appears superior to CTD in achieving a more rapid and deeper clonal response, and in improving OS in patients with advanced disease.
Machine Learning Analysis of Virus based on Transmission Electron Microscopy Images: Application to SARS-CoV-2
Authors: Dabiri Y , Kassab GS 
Published: June 2020

Abstract
The goal of this paper was to develop a machine learning (ML) platform for categorization of viruses using transmission electron microscopy (TEM) images. More efficient pathogenesis, treatment and vaccine development strategies become possible once the virus family is identified. We used three deep learning (DL) pretrained models namely AlexNet, VGG16 and SquezzeNet. The classifier portion of the models was modified and trained for the available virus dataset. We used 20% of the images (320) for testing the DL models. The dataset included TEM images from 16 virus families including novel corona virus (SARS-CoV-2). We also used two unsupervised methods to analyze image clusters: principal component analysis (PCA) and t- distributed stochastic neighbor embedding (t-SNE). The results from PCA and t-SNE were visualized based on two components. The AlexNet, VGG16 and SqueezeNet models were able to predict the categorization of test images with accuracy 77.8±4.5%, 75.3±4.7% and 77.8±4.5%, respectively. The receiver operating characteristic (ROC) curves had area under curve (AUC) greater than 0.9. Our PCA and t-STE results suggested SARS-CoV-2 is closest to Influenza family of viruses. Using DL models, TEM images can be classified into virus families. This ML approach may lead to more accurate and faster virus TEM image classification tools, which is particularly important for pandemic situations such as with the current SARS-CoV-2 crisis.
Bifunctional Inhibitors from Capsicum chinense Seeds with Antimicrobial Activity and Specific Mechanism of Action Against Phytopathogenic Fungi
Authors: da Silva Marciele Souza , Gomes Valdirene Moreira , Taveira Gabriel Bonan , de Azevedo dos Santos Layrana , Maracahipes Álan C. , Rodrigues Rosana , de Oliveira Carvalho André , Fernandes Katia Valevski S. , Oliveira Antonia Elenir A. 
Published: June 2020

Background:
Antimicrobial peptides (AMPs) are found in the defense system in virtually
all life forms, being present in many, if not all, plant species.

Objective:
The present work evaluated the antimicrobial, enzymatic activity and mechanism of action
of the PEF2 fraction from Capsicum chinense Jack. seeds against phytopathogenic fungi.

Methods:
Peptides were extracted from C. chinense seeds and subjected to reverse-phase chromatography
on an HPLC system using a C18 column coupled to a C8 guard column, then the obtained
PEF2 fraction was rechromatographed using a C2/C18 column. Two fractions, named PEF2A
and PEF2B, were obtained. The fractions were tested for antimicrobial activity on Colletotrichum
gloeosporioides, Colletotrichum lindemuthianum, Fusarium oxysporum and Fusarium
solani. Trypsin inhibition assays, reverse zymographic detection of protease inhibition and α-amylase
activity assays were also performed. The mechanism of action by which PEF2 acts on filamentous
fungi was studied through analysis of membrane permeability and production of reactive oxygen
species (ROS). Additionally, we investigated mitochondrial functionality and caspase activation
in fungal cells.

Results:
It is possible to observe that PEF2 significantly inhibited trypsin activity and T. molitor
larval α-amylase activity. The PEF2 fraction was able to inhibit the growth of C. gloeosporioides,
C. lindemuthianum and F. oxysporum. PEF2A inhibited the growth of C. lindemuthianum (75%)
and F. solani (43%). PEF2B inhibited C. lindemuthianum growth (66%) and F. solani (94%). PEF2
permeabilized F. solani cell membranes and induced ROS in F. oxysporum and F. solani. PEF2
could dissipate mitochondrial membrane potential but did not cause the activation of caspases in
all studied fungi.

Conclusion:
The results may contribute to the biotechnological application of these AMPs in the
control of pathogenic microorganisms in plants of agronomic importance.
Cubosome: A Potential Liquid Crystalline Carrier System
Authors: Sharma Pragya , Dhawan Surbhi , Nanda Sanju 
Published: June 2020

:
Cubosome is a biocompatible, thermodynamically stable and bioadhesive drug carrier that is prepared
from certain amphiphilic lipids and surfactants when mixed in a definite ratio. Structurally, they are selfassembled
nano-constructed liquid crystalline particles comprising three-dimensionally arranged bicontinuous as
well as nonintersecting lipid bilayers that give them a honeycomb-like appearance. Morphological characterization
through SAXS (small-angle X-ray scattering) and cryo-TEM (cryo-transmission electron microscopy) revealed
that they are square and round shaped particles in the nanometer range. These carriers have two separate
aqueous regions and a large interfacial area that allow them to carry a variety of bioactive molecules having hydrophobic,
hydrophilic or amphiphilic behavior.

:
One of either two strategies i.e., top-down or bottom-up methods can be adopted to prepare these cubic structures.
A number of dispersion techniques like sonication, spray drying, high-pressure homogenization or spontaneous
emulsification can be adopted to prepare cubosomes. Their characteristics and benefits like multicompartmental
structure, high drug loading, simple and convenient method of preparation, use of biodegradable lipids such as
glycerol monooleate, encapsulation of hydrophilic, hydrophobic and amphiphilic moieties, targeted and controlled
release make them versatile bioactive carriers that can be administered through multiple biological routes
like topical, transdermal, parenteral, and oral. Cubosomes have appreciable applications in various fields especially
in the pharmaceutical industry where they are used as potential bioactive carriers. Molecules like paclitaxel,
oligonucleotide, δ-amino-levulinic acid, bovine serum albumin, etc. can be easily delivered through this system.

:
This article provides a detailed note on the structure of cubosomes, ingredients and techniques used for their
preparation, mechanism of drug release, applications and routes of drug administration, their formulations, patent
review and market scenario.
Learning from Machine Learning in Accounting and Assurance
Authors: Cho Soohyun , Vasarhelyi Miklos A. , Sun Ting (Sophia) , Zhang Chanyuan (Abigail) 
Published: June 2020

ABSTRACT
Machine learning is a subset of artificial intelligence, and it is a computational method that learns patterns from large and complex data. The learning processes enable us to make predictions for future events. In the accounting and assurance profession, machine learning is gradually being applied to various tasks like reviewing source documents, analyzing business transactions or activities, and assessing risks. In academic research, machine learning has been used to make predictions of fraud, bankruptcy, material misstatements, and accounting estimates. More importantly, machine learning is generating awareness about the inductive reasoning methodology, which has long been undervalued in the mainstream of academic research in accounting and auditing. The use of machine learning in accounting/auditing research and practice is also raising concerns about its potential bias and ethical implications. Therefore, this editorial aims to call the readers' attention to these issues and encourage scholars to perform research in this domain.
WHAT WOMEN STUDENTS WANT THEIR INSTITUTIONS TO DO TO MAKE ENGINEERING EDUCATION MORE INCLUSIVE AND LESS “CHILLY”
Authors: Hanson Cori 
Published: June 2020

It has been over 30 years since science and engineering classrooms were first described as “chilly” environments for women. Since then many engineering programs in Ontario have worked to diversify their student populations with a particular focus on recruiting more women into engineering education. Despite the increase in the number of women enrolled in engineering education, incidents of sexism and microaggressions based on sexual orientation and race continue to be experienced by women in these programs. In many engineering faculties in Ontario work on equity, diversity and inclusion is still fairly new. Members of the community who are marginalized need to be consulted in order for this work to be impactful on their experience. This paper uses an intersectional framework to present preliminary results on what women studying in undergraduate engineering programs believe their universities could do to make engineering education more inclusive. This paper argues that women students in engineering are still in search of a community. Our women students want more representation of women in engineering, further education and awareness of equity issues, acknowledgement of their experiences and opportunities to connect with other women in engineering.
A Snapshot of Entrepreneurship Education at Canadian Engineering Schools – A Representative Overview from EETI SIG Members
Authors: Cao Tate N. , Bubbar Kush , Chang Wayne H. , Meister Darren , Laguë Claude , Fisher Andrew , Bailetti Tony , Hurwitz Marc , Villaume Florian 
Published: June 2020

With the rise of an innovation-based, technology-centric economy over the past two decades, there has been a shift in the market, enabling technological entrepreneurs to build business ventures that have realized accelerated growth and reached considerable scale. This “new economy” has created a need for individuals with a balanced skill set accompanying both business acumen, and technological innovation of complex systems. In esponse to this need, post-secondary engineering education institutions are teaching more business and entrepreneurship content. In Canada, most of the major post-secondary engineering education institutions offer some form of entrepreneurial education. However, approaches and programs offered by respective institutions vary in their approach to teaching engineering entrepreneurship, yielding a variety of different program implementations. There is, thus, a strong need to develop a Community of Practice focusing on engineering entrepreneurship education in Canada to foster a more rigorous and collaborative effort to evolve entrepreneurial teaching and learning. This paper is a first attempt to document and interpret the current state of a select number of Canadian Engineering Entrepreneurship Education programs. The founding members of the Canadian Engineering Education Association’s (CEEA) Engineering Entrepreneurship and technology innovation (EETI) Special Interest Group (SIG) have collaboratively collected information regarding the current practice of Engineering Entrepreneurship education within their affiliated institutions. This paper examines the Institutional Context, Strategy, Business Infrastructure, as well as the programs employed for Teaching and Learning at both the Undergraduate and Graduate levels. Our goal is to present a snapshot of the current practice for which entrepreneurship education is delivered at the institutions for which the founding members of the EETI SIG reside, as well as, discuss how entrepreneurship intersects with the other areas of engineering education, for example, design, the maker space movement, and professionalism, as well as, many of the Canadian Engineering Accreditation Board’s twelve graduate attributes.
Student & Faculty as Pedagogical Co-designers: An experience of partnership between a graduate student and a faculty member
Authors: Kao E. , McKean A. , Orjuela-Laverde M. 
Published: June 2020

• Students as Partners (SaP) is a pedagogical approach that challenges the traditional learner roles in higher education by promoting collaboration between students and faculty to enhance teaching and learning [1]• This work consists of the partnership between a new faculty member and graduate student partner (GSP) (not the course TA) to design assessment materials for a year 3 core Mech. Eng. course with ~40 students• Deliverables from the collaboration include adaptation of course rubrics (see below) and the implementation of the CATME rubric [2] for team evaluation• Rubric adaptation was in part guided from Brookhart’s book [3]
REPRESENTATION PROBLEMS OF TRANSACTIONAL COSTS IN ENTERPRISE ACCOUNTING
Authors: Pohorelov Yurii , Kozachenko Hanna , Bilousova Anastasiia 
Published: June 2020

UDC 658.012

Yurii Pohorelov, D. Sc. (Economics), assistant professor. Hanna Kozachenko, D.Sc. (Economics), professor. Anastasiia Bilousova, PhD (Economics), assistant professor. Poltava National Technical Yurii Kondratiuk University. Representation Problems of Transactional Costs in Enterprise Accounting. There is notion of “transactional costs” considered basing on the positions of epistemological contextualism. There is built in the article classification of transactional costs. There is managerial collision found about fact that not all kinds of transactional costs that are considered in cost management can be shown in accounting according to existing methodology of accounting. Taking into account regulatory framework of accounting there are three approaches suggested about accumulation of information about enterprise transactional costs. The authors analyzed advantages and limitations of suggested approaches about accounting transactional costs.

Keywords: enterprise, costs management, transactional costs, classification, accounting, representation criteria, approach for information accumulation.
SATELLITE NAVIGATION SYSTEM MARKETING
Authors: Чичкало-Кондрацька Ірина Борисівна , Добрянська Вікторія Вікторівна , Мірошниченко Володимир Тарасович 
Published: June 2020

UDC 69.003:658.8
Chychkalo-Kondratska, D.Sc. (Economics),Professor. V. Dobryanskaya, PhD (Technical),Associate Professor. V. Miroshnichenko, Senior Lecturer. Poltava National Technical Yurii Kondratyuk University. Satellite navigation system marketing. Satellite navigation system was developed as a defense project, but in recent decades, has formed a global market of users of satellite navigation systems, and manufacturers of navigational equipment. The article is devoted to analysis of market prospects by the European satellite navigation system Galileo. Conducted SWOT-analysis, allowed to conclude that the project «Galileo» has advantages and problems.
The main problem is the complexity of creating a satellite constellation, because Europe does not have its own reliable and cheap launch vehicles. The solution may be the inclusion in the draft of Ukraine, who has processed technology of rocketry.

Keywords: marketing, the global market, investment project, satellite navigation systems, launch vehicles, SWOT-analysis, marketing of the project.
INFORMATION DISCLOSURE ABOUT INVESTMENT PROPERTY IN THE FINANCIAL STATEMENTS ACCORDING TO INTERNATIONAL STANDARDS
Authors: Dubovaya Valentyna , Davydova Iryna 
Published: June 2020

UDC 657

Valentyna Dubovaya, PhD (Economics), Associate Professor. Iryna Davydova, student. Poltava National Technical Yurii Kondratiuk University. Information Disclosure about Investment Property in the Financial Statements According to International Standards. The purpose of the research is elaboration of a structured form for information disclosure of investment property in the financial statements in accordance with international standards. According to the results of research it was elucidated, that as opposed to global trends of excessive information disclosure, the financial statements of Ukrainian enterprises in accordance with IFRS has insufficient, and sometimes non-significant, financial information disclosure, at least concerning investment property. For the structured information disclosure about the investment property in the Notes to the financial statements in accordance with IFRS it was proposed an ordered presentation of descriptive and financial information with using the tabular forms of reconciliation of the carrying value of investment property at the beginning and end of the reporting period according to the alternative models of evaluation. It was defined the prospects of subsequent research of application of international accounting approach to the investment property evaluation at fair value with taking into account her best and more profitable using.
Keywords: IFRS, information disclosure, investment property, notes to the financial statements.
Qadın çanağı formalarından və yaşdan asılı olaraq uşaqlığın və yumurtalıqların morfometrik xarakteristikası
Authors: Khidirov E.A.  , Ganbaeva Sh.Ph.  
Published: June 2020

Tədqiqatın məqsədi kiçik çanaq boşluğu orqanlarından olan yumurtalıqların və uşaqlığın morfomerik göstəricilərinin öyrənilməsi olmuşdur.
Çanaq ölçülərinin öyrənilməsində olduğu kimi burada da yaş kateqoriyaları tərəfimizdən üç qrupa bölünübdür: gənclik yaşı dövrü, birinci və ikinci yetkinlik yaşı dövrləri. Əldə olunan nəticələrə əsasən demək olar ki, gənclik yaşı qrupunda çanağın normal formalarında uşaqlığın və yumurtalıqların morfometrik parametrlərinin variabelliyi dar çanaq formaları ilə müqayisədə daha yüksək olur.
Birinci yetkin yaş dövründə normal və dar çanaq formalarında daxili cinsiyyət orqanlarının ölçüləri arasında ən çox disbalans yumurtalıqların orta göstəricilərində aşkar şəkildə özünü büruzə verir. Əgər əvvəlki yaş qruplarında yüksək dispersiya keyfiyyəti normal çanaq formalarında müşahidə olunurdusa, ikinci yetkin yaş qrupunda maksimal dispersiya keyfiyyəti dar çanaq formalarının bütün parametrlərində müəyyən olunubdur.
Yekun. Aparılan tədqiqatlar zamanı əldə olunan nəticələr normal və dar çanaq formalarında kiçik çanaq boşluğu orqanlarının ölçüləri arasında meydana çıxan fərqləndirici əlamətlərin olduğunu təsdiq edir və bunun yaş aspekti baxımından artması müşahidə olunur.
Топографические особенности верхней глазничной щели новорожденных и подростков
Authors: Abdullayeva Q.M.  , Mamedova A.J.  
Published: June 2020

Цель исследования: Целью настоящего исследования является изучение морфометрических показателей верхней глазничной щели новорожденных и подростков.
Материал и методы исследования. Материалом послужили 70 черепов (30 новорожденных, 40 подростков) людей обоего пола, хранящиеся в музейной коллекции кафедры анатомии человека и медицинской терминологии Азербайджанского Медицинского Университета. В работе использовались краниометрические, краниоскопические, рентгенологические методы и метод распилов по Пирогову.
Результаты: Как показывают полученные данные у новорожденных верхняя глазничная щель бывает шире, смещена медиально и назад, у подростков ширина уменьшается, и занимает более высокое положение над ушно-глазничной горизонталью.
Заключение: Таким образом можно прийти к выводу, что верхние глазничные щели на протяжении детского возраста не растут в ширину, но высота щелей существенно увеличивается и достигает окончательных значений только в 13-16 лет.
Динамика возрастных изменений строения органов хромаффинной системы
Authors: Bashirova D.B.  , Rzayeva A.M.  
Published: June 2020

Цель исследования. Изучать динамику возрастных изменений брюшного аортального параганглия (БАП) и межсонного параганглия (МП) у человека.
Материал и методы исследования. Мы изучали строение и кровоснабжение БАП у плодов, новорожденных и детей различных возрастов (116 препаратов) и МП у плодов, новорожденных, детей и взрослых до 80 лет (по 76 препаратов-правых левых). Анатомия и топография БАП и МП изучены методом тонкой препаровки по В.П. Воробьеву. Строение и сосуды органов изучались после инъекции сосудистого русла взвесью парижской синей в хлороформе и ртутной киновари в бензине, после чего проводилась окраска срезов гемотоксилином- эозином и по Ван-Гизон.
Результаты. БАП и МП достигают полного развития во внутриутробном периоде и одинаково интенсивно функционируют в раннем детском возрасте. БАП имеет различные формы. Наиболее интенсивное увеличение размеров органа отмечается во второй половине внутриутробного развития, у новорожденных и в раннем детском возрасте. С ранних этапов развития для МП характерно дольчатое строение. Внутриорганное кровеносное русло органа содержит все сосудистые компоненты, относящиеся к микроциркуляторной системе.
Инволюция БАП начинается с 3-х лет и к 12-14 годам завершается. Структура МП у плодов, новорожденных и детей до 12-ти лет почти не изменяется. Перестройка в МП, выражающаяся в разрастании соединительной ткани, нарушении дольчатости строения органа и прогрессивном уменьшении паренхимы, начинается с 12- ти лет. Однако паренхиматозные клетки в параганглии частично сохраняются до глубокой старости.
Заключение. БАП и МП достигают полного развития во внутриутробном периоде. Оба параганглия имеют хорошо развитую паренхиматозную ткань и, судя по морфологии, одинаково интенсивно функционируют в раннем детском возрасте.