bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Resolved High-Resolution Angiography Combining Arterial Spin Labeling and Time-of-Flight Imaging
Authors: Lindner Thomas , Jansen Olav , Helle Michael 
Published: September 2020

AbstractA strategy to combine two non-contrast-enhanced magnetic resonance angiography techniques is presented. It is based on arterial spin-labeled magnetic resonance imaging to visualize the arterial system at different time points to obtain information about hemodynamic properties in conjunction with a high-resolution time-of-flight angiography acquisition. The temporal information obtained by arterial spin labeling (ASL) is combined with the highly spatial resolved time-of-flight image to obtain information about blood flow. Extracting the information of ASL and time-of-flight-imaging leads to images with high spatial resolution which also give information about the temporal course of blood through the intracerebral vasculature. Furthermore, owing to the properties of ASL, visible venous flow in the time-of-flight images can be suppressed. The behavior of vascular filling (i.e. signal changes in the ASL) is investigated and used for further interpretation of the data. Furthermore, the ASL data were down-sampled to find a minimally needed spatial resolution to combine both image types. Up to 1.6 mm isotropic resolution still showed satisfying results rated by two independent readers. In conclusion, a combination of these two different vascular imaging modalities allows to obtain highly spatial and time-resolved images.
Use of healthcare resources in a cohort of rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs or tofacitinib
Authors: Machado-Alba Jorge Enrique , Machado-Duque Manuel E. , Gaviria-Mendoza Andres , Reyes Juan Manuel , Gamboa Natalia Castaño 
Published: September 2020

AbstractIntroduction/objectivesThe objective of this study is to describe the treatment patterns and use of healthcare resources in a cohort of Colombian patients with rheumatoid arthritis (RA) treated with biological disease-modifying antirheumatic drugs (bDMARDs) or tofacitinib.MethodThis is a descriptive study from a retrospective cohort of patients diagnosed with RA who were treated with bDMARDs or tofacitinib after failure of conventional DMARDs (cDMARDs) or first bDMARD. Patients who were receiving pharmacological treatment between 01 January 2014 and 30 June 2018 were included. The analysis is through the revision of claim database and electronical medical records. Demographic and clinical data were collected. The costs of healthcare resources were estimated from the billing expense of healthcare service provider.ResultsWe evaluated 588 RA patients on treatment with bDMARDs (n= 505) or tofacitinib (n= 83), most of them were in combination with cDMARDs (85.4%). The 88.1% were females and mean age was 57.3 ± 12.5 years. The median evolution of RA since diagnosis was 9 years (IQR:4–17.2). The mean duration of use during follow-up of the bDMARDs or tofacitinib was similar, with a mean of 9.8 ± 1.9 months. It was identified that 394 (67.0%) discontinued therapy. The average annual direct cost of care per patient was USD 8997 ± 2172, where 97.2% was due to drug costs. The average annual cost of treatment per patient with bDMARDs was USD 8604 and tofacitinib was USD 6377.ConclusionsIn the face of a first failure of cDMARD, bDMARDs are frequently added. A high frequency of patients do not persist treatment during the first year of follow-up. The pharmacological treatment is the most representative cause of healthcare costs.Key Points• Rheumatoid arthritis is a disease with a high burden of comorbidities, complications, and worse health-related quality of life and is associated with elevated healthcare costs.• The biological disease-modifying antirheumatic drugs or tofacitinib medications are indicated for those with significant progression of the disease and when there is a need for alternatives to achieve low levels of activity and remission.• Patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs or tofacitinib represent a significant economic burden to the health system, especially in the costs derived from pharmacological treatment.
Resources and benchmark corpora for hate speech detection: a systematic review
Authors: Poletto Fabio , Basile Valerio , Sanguinetti Manuela , Bosco Cristina , Patti Viviana 
Published: September 2020

AbstractHate Speech in social media is a complex phenomenon, whose detection has recently gained significant traction in the Natural Language Processing community, as attested by several recent review works. Annotated corpora and benchmarks are key resources, considering the vast number of supervised approaches that have been proposed. Lexica play an important role as well for the development of hate speech detection systems. In this review, we systematically analyze the resources made available by the community at large, including their development methodology, topical focus, language coverage, and other factors. The results of our analysis highlight a heterogeneous, growing landscape, marked by several issues and venues for improvement.
Unannounced Evacuation Experiment in a High-Rise Hotel Building with Evacuation Elevators: A Study of Evacuation Behaviour Using Eye-Tracking
Authors: Mossberg Axel , Nilsson Daniel , Andrée Kristin 
Published: September 2020

AbstractPast studies suggest that people are often reluctant to use occupant evacuation elevators in case of fire. However, existing research is scarce and current knowledge is based on questionnaire studies and laboratory experiments. An unannounced evacuation experiment was therefore performed on the 16th floor of a 35-floor high-rise hotel building. Sixty-seven participants took part and eye-tracking glasses were used to collect data on exit choice and eye fixations. Three different scenarios were studied, including two different hotel room locations on the floor and a variation of guidance system for one of these locations, i.e., flashing green lights next to the evacuation sign at the elevators. Results suggest that people typically choose the elevator for evacuation, even if their hotel room was located closer to the evacuation stair. Flashing green lights next to an evacuation sign made people look more at this sign. However, in spite of looking more at the sign, the flashing light was not shown to significantly improve compliance with the sign. Also, the results suggest that a detector activated self-closing fire door without vision panels to the elevator lobby made it more difficult to find the evacuation elevators in an emergency.
“The Ones that Care Make all the Difference”: Perspectives on Student-Faculty Relationships
Authors: Guzzardo Mariana T. , Khosla Nidhi , Adams Annis Lee , Bussmann Jeffra D. , Engelman Alina , Ingraham Natalie , Gamba Ryan , Jones-Bey Ali , Moore Matthew D. , Toosi Negin R. , Taylor Sarah 
Published: September 2020

AbstractStudent-faculty (S-F) interactions that are conducive to students’ learning can help reduce the retention and graduation gaps in higher education, especially for college students from underrepresented and underprivileged backgrounds. The aim of the study was to explore students’ perceptions of their interactions with faculty, and the subjective impact of these interactions on students’ academic and personal life. We analyzed qualitative data from a larger study with the goal of providing best practice models to support students experiencing displacement and food insecurity. Through purposive sampling techniques, 53 students from a diverse public university were recruited. Recruitment strategies focused on students who were likely to be facing academic, personal, and/or financial challenges that may affect their academic performance. Students were interviewed three to four times over a four to six-month period, using semi-structured interview guides. Our multidisciplinary team analyzed data thematically in team-based coding sessions using an online software. We identified four themes for faculty practices: (1) Creating Pedagogical Space, (2) Being Inclusive and Aware, (3) Being Engaged and Engaging Students, (4) Doing More Than Teaching. Based on students’ perspectives, these practices lead to supportive and responsive S-F relationships that facilitate learning and success. The findings have implications related to how faculty can encourage caring S-F relationships and create conducive learning environments where students can thrive, especially during times of crisis.
Depression, anxiety, and loneliness among adolescents and young adults with IBD in the UK: the role of disease severity, age of onset, and embarrassment of the condition
Authors: Qualter Pamela , Rouncefield-Swales Alison , Bray Lucy , Blake Lucy , Allen Steven , Probert Chris , Crook Kay , Carter Bernie 
Published: September 2020

Abstract
Purpose
Adolescents and young adults (AYA) with Inflammatory Bowel Disease (IBD) report higher depressive symptoms and anxiety compared to healthy controls, with disease severity and abdominal pain being important factors. In the current study, building on what young people had told us in our previous work, we examined whether embarrassment of the condition, social self-efficacy, and friendship quality mediated the relationship between abdominal pain and disease severity, and mental health/well-being. We also included loneliness as a component of well-being.

Methods
Data on depression, anxiety, loneliness, friendship quality, social self-efficacy, and disease embarrassment were collected from 130 AYA with IBD ages 14–25 years; data on disease severity and abdominal pain were taken from their medical records. Structural Equation Modeling (SEM) was used to test the relationships between the variables.

Results
Using SEM, we established that higher IBD disease activity negatively impacted how AYA felt about their friendships and how embarrassed they were about their condition; embarrassment then influenced reports of mental health, including loneliness. Abdominal pain, disease onset, and social self-efficacy directly predicted internalising problems.

Conclusion
In this sample of 14–25-year-old patients with IBD, specifics about the disease (severity and pain) predicted poorer mental health, suggesting discussion of mental health should be part of the clinical dialogue between patient and consultant. In addition, embarrassment about their condition increased depression, anxiety, and loneliness, mediating the relationship between disease severity and well-being. Thus, it is important to consider how perceived stigma affects those with chronic illness, and those issues should be explored in clinic.
4D deep learning for real-time volumetric optical coherence elastography
Authors: Neidhardt M. , Bengs M. , Latus S. , Schlüter M. , Saathoff T. , Schlaefer A. 
Published: September 2020

Abstract
Purpose
Elasticity of soft tissue provides valuable information to physicians during treatment and diagnosis of diseases. A number of approaches have been proposed to estimate tissue stiffness from the shear wave velocity. Optical coherence elastography offers a particularly high spatial and temporal resolution. However, current approaches typically acquire data at different positions sequentially, making it slow and less practical for clinical application.

Methods
We propose a new approach for elastography estimations using a fast imaging device to acquire small image volumes at rates of 831 Hz. The resulting sequence of phase image volumes is fed into a 4D convolutional neural network which handles both spatial and temporal data processing. We evaluate the approach on a set of image data acquired for gelatin phantoms of known elasticity.

Results
Using the neural network, the gelatin concentration of unseen samples was predicted with a mean error of 0.65 ± 0.81 percentage points from 90 subsequent volumes of phase data only. We achieve a data acquisition and data processing time of under 12 ms and 22 ms, respectively.

Conclusions
We demonstrate direct volumetric optical coherence elastography from phase image data. The approach does not rely on particular stimulation or sampling sequences and allows the estimation of elastic tissue properties of up to 40 Hz.
Evaluating Wrongness Constraints on Criminalisation
Authors: Pearce Adam R. 
Published: September 2020

AbstractSome claim that criminalisation is morally permissible only when the conduct criminalised is morally wrong. This claim can be disambiguated into at least three principles which differ according to whether, and how, wrongness is dependent on details of the law: the strong constraint, the moderate constraint, and the weak constraint. In this paper I argue that the weak wrongness constraint is preferable to the strong and moderate constraints. That is, we should prefer the view that conduct criminalised must be morally wrong, but qualifying wrongness can depend on criminalising the conduct first. Further, I will show that my arguments in support of the weak wrongness constraint have wider implications. Favouring the weak wrongness constraint implies that condemning wrongs cannot be the only legitimate reason in favour of criminalisation. Those who think condemnation can justify criminalisation should be pluralists.
Ethylenediurea (EDU) effects on Japanese larch: an one growing season experiment with simulated regenerating communities and a four growing season application to individual saplings
Authors: Agathokleous Evgenios , Kitao Mitsutoshi , Wang Xiaona , Mao Qiaozhi , Harayama Hisanori , Manning William J. , Koike Takayoshi 
Published: September 2020

AbstractJapanese larch (Larix kaempferi (Lamb.) Carr.) and its hybrid are economically important coniferous trees widely grown in the Northern Hemisphere. Ground-level ozone (O3) concentrations have increased since the pre-industrial era, and research projects showed that Japanese larch is susceptible to elevated O3 exposures. Therefore, methodologies are needed to (1) protect Japanese larch against O3 damage and (2) conduct biomonitoring of O3 in Japanese larch forests and, thus, monitor O3 risks to Japanese larch. For the first time, this study evaluates whether the synthetic chemical ethylenediurea (EDU) can protect Japanese larch against O3 damage, in two independent experiments. In the first experiment, seedling communities, simulating natural regeneration, were treated with EDU (0, 100, 200, and 400 mg L−1) and exposed to either ambient or elevated O3 in a growing season. In the second experiment, individually-grown saplings were treated with EDU (0, 200 and 400 mg L−1) and exposed to ambient O3 in two growing seasons and to elevated O3 in the succeeding two growing seasons. The two experiments revealed that EDU concentrations of 200–400 mg L−1 could protect Japanese larch seedling communities and individual saplings against O3-induced inhibition of growth and productivity. However, EDU concentrations ≤ 200 mg L−1 did offer only partial protection when seedling communities were coping with higher level of O3-induced stress, and only 400 mg EDU L−1 fully protected communities under higher stress. Therefore, we conclude that among the concentrations tested the concentration offering maximum protection to Japanese larch plants under high competition and O3-induced stress is that of 400 mg EDU L−1. The results of this study can provide a valuable resource of information for applied forestry in an O3-polluted world.
Follow-up Study of Microflora Changes in Crevicular Gingival Fluid in Obese Subjects After Bariatric Surgery
Authors: Balogh Bettina , Somodi Sándor , Tanyi Miklós , Miszti Cecília , Márton Ildikó , Kelentey Barna 
Published: September 2020

AbstractThe objective of our study was to investigate the effect of weight loss on the crevicular microflora following bariatric surgery. Crevicular fluid samples were taken from 57 subjects: 22 were in the normal control group; 18 in the obese control group; and 17 patients had had bariatric surgery, who underwent a repeat sampling 6 to 12 months after the operation. Crevicular fluid samples were analyzed by MALDI-TOF MS analysis. After surgery and weight loss, the mean germ count increased, albeit not significantly. Also, Candida albicans and non-albicans Candida species: C. dubliniensis, C. kefyr, and C. lusitaniae appeared after surgery (p < 0.05) in subjects where Neisseria was either absent throughout or eliminated after surgery. However, periodontitis did not develop during this time in our subjects.
The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients
Authors: Ayerbe Luis , Risco-Risco Carlos , Ayis Salma 
Published: September 2020

AbstractThis study investigates the association between the treatment with hydroxychloroquine and mortality in patients admitted with COVID-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with COVID-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used. The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with hydroxychloroquine, azithromycin, heparin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. Multivariable logistic regression models were used to investigate the associations. At the time of collecting the data, 301 patients had died, 1449 had been discharged home from the hospitals, 240 were still admitted, and 85 had been transferred to hospitals not included in the study. Median follow-up time was 8 (IQR 5–12) days. Hydroxychloroquine had been used in 1857 patients. Hydroxychloroquine was associated with lower mortality when the model was adjusted for age and gender, with OR (95% CI): 0.44 (0.29–0.67). This association remained significant when saturation of oxygen < 90% and temperature > 37 °C were added to de model with OR 0.45 (0.30–0.68)p < 0.001, and also when all the other drugs, and time of admission, were included as covariates. The association between hydroxychloroquine and lower mortality observed in this study can be acknowledged by clinicians in hospitals and in the community. Randomized-controlled trials to assess the causal effects of hydroxychloroquine in different therapeutic regimes are required.
Macbeth in der Forensik
Authors: Triebenecker Franz , Orlob Stefan 
Published: September 2020

ZusammenfassungDer psychiatrische Raum kennt viele unterschiedliche Zimmer und Korridore. Es gibt erhebliche Unterschiede zwischen den verschiedensten Kliniken und Institutionen. Eine offene Tagesklinik ist nicht vergleichbar mit dem geschlossenen Maßregelvollzug. Beide nutzen aber bisweilen Methoden, die das Theater bereitstellt. Dabei reicht die Spannbreite von einfachen, improvisierten Rollenspielen bis hin zu professionellen, technisch aufwendigen Inszenierungen vor einem kritisch interessierten Publikum. Zentrale Fragen sind dabei, wie wirkt Theaterspielen, kann es tatsächlich heilen, und wie verhält sich der künstlerische Anspruch zur Therapie? Diese will der nachfolgende Beitrag anhand mehrjähriger praktischer Erfahrungen in einer Maßregelvollzugsklinik aufgreifen.
A New Synuclein-Transgenic Mouse Model for Early Parkinson’s Reveals Molecular Features of Preclinical Disease
Authors: Hendrickx Diana M. , Garcia Pierre , Ashrafi Amer , Sciortino Alessia , Schmit Kristopher J. , Kollmus Heike , Nicot Nathalie , Kaoma Tony , Vallar Laurent , Buttini Manuel , Glaab Enrico 
Published: September 2020

AbstractUnderstanding Parkinson’s disease (PD), in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post-mortem, reflecting mainly end-stage disease. Because brain samples of mouse models can be collected at any stage of the disease process, they are useful in investigating PD progression. Here, we compare ventral midbrain transcriptomics profiles fromα-synuclein transgenic mice with a progressive, early PD-like striatal neurodegeneration across different ages using pathway, gene set, and network analysis methods. Our study uncovers statistically significant altered genes across ages and between genotypes with known, suspected, or unknown function in PD pathogenesis and key pathways associated with disease progression. Among those are genotype-dependent alterations associated with synaptic plasticity and neurotransmission, as well as mitochondria-related genes and dysregulation of lipid metabolism. Age-dependent changes were among others observed in neuronal and synaptic activity, calcium homeostasis, and membrane receptor signaling pathways, many of which linked to G-protein coupled receptors. Most importantly, most changes occurred before neurodegeneration was detected in this model, which points to a sequence of gene expression events that may be relevant for disease initiation and progression. It is tempting to speculate that molecular changes similar to those changes observed in our model happen in midbrain dopaminergic neurons before they start to degenerate. In other words, we believe we have uncovered molecular changes that accompany the progression from preclinical to early PD.
Outcome of CentriMag™ extracorporeal mechanical circulatory support use in critical cardiogenic shock (INTERMACS 1) patients
Authors: Mehta Vipin , Venkateswaran Rajamiyer V. 
Published: September 2020

Abstract
Purpose
Prognosis of patients presenting with INTERMACS 1 critical cardiogenic shock is generally poor. The aim of our study was to investigate the results of CentriMag™ extracorporeal short-term mechanical circulatory support as a bridge to decision in patients presenting with critical cardiogenic shock in our unit.

Methods
We retrospectively analysed 63 consecutive patients from January 2005 to June 2017, who were treated with a CentriMag™ device at our institution as a bridge to decision. Patients requiring extracorporeal support for post-cardiotomy shock and for primary graft dysfunction after heart transplantation were excluded.

Results
Patients’ median age was 44 years (IQR 31–52, range 15.4–62.0) and 42 (67%) were male. Primary diagnosis at presentation was ischaemic cardiomyopathy (n = 24; 38.1%), viral myocarditis (n = 19; 30.2%), idiopathic dilated cardiomyopathy (n = 8; 12.7%), and others (n = 12; 19%). The median duration of support was 25 (IQR 9.5–56) days. A total of 7 (11%) patients were supported with peripheral veno-arterial (VA) extra corporeal membrane oxygenation (ECMO), 6 (9%) with central VA ECMO, 8 (13%) with left ventricular assist device (LVAD), 17 (27%) with biventricular assist device (BiVAD), and 25 (40%) with ECMO and then converted to BiVAD. Overall, 22 (34.9%) patients died while on CentriMag™ mechanical circulatory support. Complications included bleeding requiring reoperation/intervention in 24 (38%), renal failure requiring dialysis in 29 (46%), bacterial infections in 23 (37%), fungal infections in 15 (24%), critical limb ischaemia in 6 (10%), and stroke in 8 (13%). The overall survival to successful explant from CentriMag™ was 65.1% (n = 41) and survival to hospital discharge was 58.7% (n = 37). Of these, 10 (16%) had cardiac recovery and were successfully explanted, 20 (32%) were bridged to heart transplantation, 11 (17%) were bridged to long-term left ventricular assist device, 3 (4.7%) were later on transplanted, and 1 (1.6%) recovered to decommissioning. The 1-, 5-, and 10-year survival rates were 55%, 46%, and 23% respectively.

Conclusion
Our results demonstrate an excellent outcome with the use of the CentriMag™ device in this seriously ill population. Despite requiring multiple procedures, over 58% of patients were discharged from hospital with 5-year survival of 46%.