bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co occurrence of two 16S rRNA methyltrasferases along with NDM and OXA 48 like carbapenamases on a single plasmid in Klebsiella pneumoniae
Authors: L. Aishwarya K. V. , Geetha P. V. , Shanthi M. , Uma S. 
Published: December 2019

Abstract
BACKGROUND: The carbapenemase-encoding genes, bla

NDM-
and bla

OXA-48

-

like
, confer resistance to all the known beta-lactams and are encountered along with other beta-lactamase-encoding genes and/or 16S ribosomal RNA (rRNA)-methylating genes. The co-occurrence of bla

NDM
and bla

OXA-48

-

like
on a single plasmid is a rare occurrence.
AIM AND OBJECTIVE: The purpose of the study was to characterize the plasmids in Klebsiella pneumoniae isolates producing 16S rRNA methyltransferase along with bla

NDM
, bla

OXA-48-like
, and other resistance encoding genes.
MATERIALS AND METHODS: One-hundred and seventeen K. pneumoniae clinical isolates which were resistant to aminoglycosides were collected. Polymerase chain reaction-based screening for 16S rRNA methyltransferase genes armA, rmtB, and rmtC; carbapenamase genes bla

NDM
, bla

OXA-48-like
, bla

IMP,

bla

VIM,
and bla

KPC
; and other resistance genes such as bla

TEM,

bla

SHV,

bla

CTX-M
, and qnr (A, B, and S) determinants acc (6') Ib-cr was performed. Conjugation experiment was carried out for seven isolates that anchored bla

NDM
and bla

OXA-48-like
along with any one of the 16S rRNA methyltransferases. The plasmid-based replicon typing for different plasmid-incompatible (Inc) group was performed on the conjugatively transferable plasmids.
RESULTS: Among the 16S rRNA methyltransferases, armA was more predominant. bla

NDM
and bla

OXA-48

-like
were present in 56 (47.86%) and 22 (18.80%) isolates, respectively. Out of seven isolates which were conjugatively transferable, only four had bla

NDM
and bla

OXA-48

-

like
on the same plasmid and they belonged to Inc N and A/C replicon. Three isolates co-harbored 16S rRNA methyltransferases armA, rmtB, and rmtC, and out of the them, one isolate harbored two 16S rRNA methyltransferases armA and rmtB, on the single-plasmid replicon A/C.
CONCLUSION: This is the first report revealing the coexistence of bla

NDM
and bla

OXA-48

-

like
co-harboring two 16S rRNA methylases on a single conjugative plasmid replicon belonging to incompatibility group A/C.
Evaluation of prognostic utility of Ki-67, P53, and O-6-methylguanine-DNA methyltransferase expression in pituitary tumors
Authors: Das Chhanda , Mondal Pratap , Mukhopadhyay Madhumita , Mukhopadhyay Satinath , Ghosh Ipsita , Handral Anusha 
Published: December 2019

Abstract
BACKGROUND OR CONTEXT: Pituitary adenoma (PA) is the most common pathology of the pituitary gland. Pituitary tumors were historically considered benign, however, from recent advances in pathological and molecular analyses, numerous prognostic markers have been identified, allowing a better characterization of tumor behavior and prediction of response to treatment and recurrences.
AIMS AND OBJECTIVES: Evaluation of the epidemiological occurrence of pituitary tumors in our center and prediction of the benign, aggressive, or malignant nature of the tumor with the help of immunohistochemical markers (IHC) Ki-67, P53, and O-6-methylguanine-DNA methyltransferase (MGMT) along with radiology.
MATERIALS AND METHODS: A prospective study was done in 33 cases. Patients with clinically suspected pituitary tumors and related symptoms and signs are referred from the endocrine outpatient department and subsequently operated at the neurosurgery department were selected. We have studied the clinical features, radiology, histopathology, and IHC with the help of Ki-67, P53, and MGMT of PA over 2 years.
RESULTS: We have 94% (31/33) cases of PA among them 94% (29/31) cases are macroadenoma. The IHC was conducted on 30 cases (excluding 1 case of pituitary apoplexy) where Ki-67, p53, and MGMT have been used for IHC in order to analyze the prognosis of the PA, irrespective of the immunological subtype of the PA. In our study, only 13% (4 patients) had MGMT score 0 and 2 patients, among these 4 patients having above cutoff level of Ki-67 and p53 value, considered as aggressive (in case of Ki-67 >3% and >50% in case of p53). When comparing MGMT expression with recurrence, a high degree of significance was found (Mann–Whitney U-test, P = 0.0038). Most of the recurrent tumors (6/9) had MGMT score 1 or below and most of the nonrecurring tumor had MGMT score 2 or above. When comparing MGMT expression with aggressiveness, a high degree of significance was found (Mann–Whitney U-test, P < 0.0001). Finally, combining the radiological Ki-67, p53, and MGMT values, two cases of aggressive adenoma have been seen in our study, the remaining being benign adenomas (WHO classification 2004). We did not encounter any case of pituitary carcinoma. MGMT did not show any significant correlation with radiological grading and histology.
CONCLUSION: The benign, aggressive, or malignant nature of PA can be effectively predicted with the help of IHC, such as Ki-67, p53, and MGMT. This helps in better patient management and predicts recurrences and prognosis.
Sobre a Lenha, Labareda Sou: Poética da Memória em um Canto Ritual Krahô
Authors: Packer Ian 
Published: December 2019

Apresento aqui a transcrição e a tradução da letra de um canto krahô, povo ameríndio falante de uma língua Jê e que vive no norte do estado do Tocantins. Este canto é um exemplar de um dos diversos gêneros de arte verbal encontrados entre os Krahô e que constituem formasexpressivas centrais em seu vasto e complexo sistema ritual. Proponho aqui um exercício cruzado em que o comentário etnográfico enriquece a tradução e o comentário sobre a tradução enriquece a etnografia, ambos movimentos contribuindo para uma compreensão mais detalhada do texto e de seu contexto. A partir disso, interpreto esse canto como uma reflexãosobre seu próprio processo de transmissão e como local de elaboração de uma poética da memória.
Technical note: PaleoDataView – a software toolbox for the collection, homogenization and visualization of marine proxy data
Authors: Langner Michael , Mulitza Stefan 
Published: December 2019

Abstract. We present a software toolbox that allows the efficient collection, management and maintenance of larger paleoceanographic data sets. The program combines a graphical user interface (GUI) with a simple document-based database and functionality for visualization, stratigraphy (visual alignment and radiocarbon calibration), age modelling and efficient ensemble time-series generation to create larger homogenous data compilations. Data can be imported from Excel or text files, are stored locally in netCDF format and can be easily exchanged between collaborating scientists. Within a data collection, data can be imported either to proxy-specific sub-collections or to a multi-proxy (“miscellaneous”) sub-collection that allows the import and management of any downcore data. A single
age model is shared among all proxies of a core within a collection. The
stand-alone software can be used with Windows and macOS and does not require
web access. Installers of the current version for both Windows 10 and macOS including the C++ code can be downloaded from https://www.marum.de/Stefan-Mulitza/PaleoDataView.html (last access: 5 December 2019) along with a detailed user guide.
Negative Utopianism and Catastrophe in Margaret Atwood's MaddAddam Trilogy
Authors: Jergenson Casey 
Published: December 2019

ABSTRACT
This article considers Margaret Atwood's MaddAddam Trilogy as an exemplar of the principle that dystopian and postapocalyptic narratives often serve as vehicles for utopian hopes in anti-utopian historical moments. The trilogy expresses utopian possibilities through the procedures of negative utopianism: a set of discursive practices oriented toward utopian horizons but informed by the principle that utopia cannot be represented from a position within ideology. The Crakers and the God's Gardeners are the two utopian entities in the trilogy, and the social content attributed to them is generated through two qualitatively distinct approaches to utopian representation that Fredric Jameson has theorized using the Greimasian semiotic rectangle. Both entities fail, but the trilogy places utopian hope in the possibility for their combination, facilitated by an apocalyptic catastrophe that creates space in the world of the trilogy for alternative configurations of the social. These alternatives, however, are deferred beyond the trilogy's conclusion.
The Awakenings of Charlotte Perkins Gilman
Authors: Paravantes Andrew James 
Published: December 2019

ABSTRACT
“The sleeper awakes” is a convention of many literary utopias from the late nineteenth and early twentieth centuries. Novels by Wells, Morris, and Bellamy famously feature a sleeping modern everyman who awakens to a future where the contradictions of the burgeoning capitalist society have (fitfully or finally) been resolved. Charlotte Perkins Gilman (1860–1935) dutifully employed this trope in her first full-length utopia, Moving the Mountain (1911). More important, a general invocation to “Awaken!” runs throughout the entirety of her work. To “awaken” meant for Gilman to waken from: to throw off the inherited habits of thought that mentally hobbled her generation and to rouse oneself from the debilitating fatigue that was a consequence of domestic drudgery. Gilman also called upon women to waken to: to grasp their productive capacity as world workers; to seize their reproductive power as “mothers of the race”; and, finally, to acknowledge their capacity for telesis, that is, for the deliberate improvement of human society. Gilman's failure to critically challenge the myopia of her own thinking, however, particularly around matters of race, meant that she remained “half-asleep,” or perhaps better, “half-woke.”
Diretrizes políticas Globais e Relações Políticas Locais: possíveis indícios da “gestão-vagalume"
Authors: Araujo Arthur Medrado Soares 
Published: December 2019

Esses escritos pretendem analisar os conceitos apresentando por BALL (2001) no texto Diretrizes Políticas Globais e Relações Políticas Locais em Educação em relação ao relato de experiência de três professoras/gestoras da educação publica de Minas Gerais no que tange a relação dessas “atrizes sociais” com ações educativas e suas práticas no campo da gestão educacional. A tentativa, então, é encontrar os atravessamentos entre a literatura e a prática no testemunho dos sujeitos que estão no “chão da escola”. Para isso foram utilizadas entrevistas com as professoras para a Série Educacional Mosaico, produzida pela Escola de Gestores do CEAD/UFOP na intenção de buscar conexões e afastamentos do texto de BALL e as possíveis “causas” para denominar essas mulheres como “vagalumes” (HUBERMAN,2011).
Bibliometric analysis about Economics approach to Bitcoins
Authors: Sokulski Carla Cristiane , Moura Rafael Vignoli de , Waldmann Gustavo Tadra , Francisco Antonio Carlos de , Carvalho Gustavo Dambiski Gomes de 
Published: December 2019

The objective of this article is to identify the main characteristics of scientific research regarding the approach economic about bitcoins. This study is based on bibliometric research and network analysis, with the use of descriptive statistics in 84 articles found on the Web of Science database. The analysis used the programs VOSviewer and Excel. The main results show that Bouri, Bouoiyour, Dyhrberg and Selmi are the authors who published most articles and that the Université de Pau (France) and the University College Dublin (Ireland) are the institutions with most publications. The journal with most publications is Plos One, which presented a 3.057 impact factor. There are only three co-authoring networks with greater expressiveness, however, there are no links between them and the others. Despite the growing number of publications on the subject, the researchs is beginning, showing a wide field of exploration.
O Esporte nas Constituições dos Países da América Latina: Pesquisa Descritiva Sob o Olhar do Direito
Authors: Malanovicz Aline Vieira , Malanovicz Ana Paula Vieira 
Published: December 2019

Objetivo do estudo: Esta pesquisa tem como objetivo identificar menções ao tema do esporte nas Constituições dos países da América Latina.Metodologia/abordagem: O corpus da pesquisa incluiu os textos das Constituições de 32 países, e os dados foram coletados com base em palavras-chave referentes ao tema esporte, em quatro idiomas (sport, deporte, esporte). A análise dos dados coletados utilizou o método comparativo.Originalidade/Relevância: Esta pesquisa tem certa originalidade no sentido de que é pautada em uma discussão sob o olhar do Direito, e realizou a coleta de dados sobre o tema do Esporte em textos constitucionais.Principais resultados: Para resumir os resultados, pode-se dizer que as seções em que os artigos que tratam do esporte aparecem abordam três temas principais: os direitos e garantias fundamentais ou sociais, o dever ou atribuição do Estado de promover o esporte, e a organização das competências do Estado – o que evidencia perfeito sentido lógico (declaração do direito, atribuição do dever ao Estado, organização da competência para realizá-lo). Entretanto, uma discussão da efetividade da declaração do direito ao esporte – ainda que na Constituição do país, na norma hierarquicamente superior a todas as outras e fundante de toda a estrutura do estado de direito – mostra que, em algumas realidades investigadas em pesquisas, a efetividade ainda parece distante de uma plenitude em termos de eficácia. Conclui-se que, sendo o esporte reconhecido como tendo um valor social tão relevante, de modo a estar elencado na ordem social na lei máxima do ordenamento jurídico, nas Constituições de alguns países, espera-se que a efetividade das normas programáticas seja instrumentalizada o suficiente para tornar tais direitos efetivos, não apenas simples declarações de intenções.Contribuições teóricas/metodológicas: apresenta-se uma base para coleta de dados não usual na área dos Esportes, e adequada para pesquisas cujo objetivo esteja vinculado à identificação da valorização do tema em diferentes países. O olhar do Direito também configura uma contribuição metodológica relevante, pela diferença no ponto de vista de análise dos dados.
Distinguer les risques sanitaire et nutritionnel perçus pour améliorer les comportements alimentaires
Authors: Laporte Marie-Ève 
Published: December 2019

L’alimentation est étroitement liée au bien-être et à la santé. De ce fait, elle suscite aussi des inquiétudes. La présente recherche étudie la perception du risque alimentaire à travers ses deux dimensions théoriques : (1) la perception de risque sanitaire à court terme et (2) la perception de risque nutritionnel à long terme. Elle vérifie par deux études quantitatives en France que les consommateurs distinguent ces deux dimensions et que la seconde est désormais prépondérante. Le renforcement des normes pour lutter contre le risque sanitaire a paradoxalement créé une distance entre le consommateur et son assiette, accroissant la perception de risque nutritionnel. Il apparaît nécessaire de prendre celle-ci en compte pour rassurer les consommateurs, sans pour autant négliger le risque sanitaire. L’article analyse différentes solutions de le faire en pratique.
Effect of music listening on hypertonia in neurologically impaired patients—systematic review
Authors: Van Criekinge Tamaya , D’Août Kristiaan , O’Brien Jonathon , Coutinho Eduardo 
Published: December 2019

BackgroundAs music listening is able to induce self-perceived and physiological signs of relaxation, it might be an interesting tool to induce muscle relaxation in patients with hypertonia. To this date effective non-pharmacological rehabilitation strategies to treat hypertonia in neurologically impaired patients are lacking. Therefore the aim is to investigate the effectiveness of music listening on muscle activity and relaxation.MethodologyThe search strategy was performed by the PRISMA guidelines and registered in the PROSPERO database (no. 42019128511). Seven databases were systematically searched until March 2019. Six of the 1,684 studies met the eligibility criteria and were included in this review. Risk of bias was assessed by the PEDro scale. In total 171 patients with a variety of neurological conditions were included assessing hypertonia with both clinicall and biomechanical measures.ResultsThe analysis showed that there was a large treatment effect of music listening on muscle performance (SMD 0.96, 95% CI [0.29–1.63],I2 = 10%,Z = 2.82,p = 0.005). Music can be used as either background music during rehabilitation (dual-task) or during rest (single-task) and musical preferences seem to play a major role in the observed treatment effect.ConclusionsAlthough music listening is able to induce muscle relaxation, several gaps in the available literature were acknowledged. Future research is in need of an accurate and objective assessment of hypertonia.
The complete mitochondrial genome of stag beetle Lucanus cervus (Coleoptera: Lucanidae) and phylogenetic analysis
Authors: Chen Dan , Liu Jing , Bartolozzi Luca , Wan Xia 
Published: December 2019

Background
The stag beetle Lucanus cervus (Coleoptera: Lucanidae) is widely distributed in Europe. Habitat loss and fragmentation has led to significant reductions in numbers of this species. In this study, we sequenced the complete mitochondrial genome of L. cervus and reconstructed phylogenetic relationships among Lucanidae using complete mitochondrial genome sequences.

Methods
Raw data sequences were generated by the next generation sequencing using Illumina platform from genomic DNA of L. cervus. The mitochondrial genome was assembled by IDBA and annotated by MITOS. The aligned sequences of mitochondrial genes were partitioned using PartitionFinder 2. Phylogenetic relationships among 19 stag beetle species were constructed using Maximum Likelihood (ML) method implemented in IQ-TREE web server and Bayesian method implemented in PhyloBayes MPI 1.5a. Three scarab beetles were used as outgroups.

Results
The complete mitochondrial genome of L. cervus is 20,109 bp in length, comprising 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNAs and a control region. The A + T content is 69.93% for the majority strand. All protein-coding genes start with the typical ATN initiation codons except for cox1, which uses AAT. Phylogenetic analyses based on ML and Bayesian methods shown consistent topologies among Lucanidae.
Evaluation of Acute and Sub-acute Toxicity of the Aqueous Extract from the Fruit of Solanum indicum Linn. (Solanaceae) in Rats
Authors: Epoh Nadine Joissy , Dongmo Olivette Laure Matafack , Tadjoua Herve Tchoumbou , Tchouanguep Félicité Mbiapo , Telefo Phelix Bruno 
Published: December 2019

Aim: The fruit of Solanum indicum Linn have been reported traditionally to have anti-hypertensive and diuretic properties. This study was undertaken to evaluate the toxicological potential of S. indicum fruits aqueous extract through the acute and sub-acute toxicity tests in rats.
Methodology: For acute toxicity evaluation, a single oral dose of 5000 mg/kg of the plant extract was administrated in 60 days old female albino Wistar rats. Then, the animals were observed for 14 days. Sub-acute toxicity studies were conducted with 50 adult rats of both gender that orally received during 28 days, increasing doses of the plant extract. Their body weight and food intake were weekly collected. At the end of the experiment, biochemical and hematological parameters as well as histological analysis of organs (liver, kidneys and spleen) were undertaken.
Results: Single oral administration of 5000 mg/kg dose of the fruit plant aqueous extract produced no mortality or signs of toxicity. During sub-acute test, no variations in body weight and food intake of both animals gender were observed. An important decrease in male’s rat liver weight were obtained at the dose 25 mg/kg; serum urea, total cholesterol, TAG, ALP and AST levels were signiﬁcantly lowered in male especially at the dose 50 mg/kg, but this decrease was noticed only in serum urea, ALP and ALT in female rats. Furthermore, a significant decrease in platelets number, serum PCT, MPV and PDW levels were recorded in all treated male rats except those receiving the highest extract dose. No structural changes in treated animal organs section histology were observed when compared to controls.
Conclusion: The fruits aqueous extracts of S. indicum is safe when administered acutely and for 28 days in rats. However, alterations on their hematological and biochemical parameters were not closely related with the dose, implying caution on its use.
TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas
Authors: Wang Huizhi , Chen Zihang , Wang Shaobo , Gao Xiao , Qian Mingyu , Qiu Wei , Zhang Zongpu , Zhang Shouji , Qi Yanhua , Sun Xiaopeng , Xue Hao , Guo Xing , Zhao Rongrong , Li Gang 
Published: December 2019

Gliomas are the most common primary malignant tumours of the central nervous system, and new molecular biomarkers are urgently needed for diagnosis and targeted therapy. Here, we report that increased beta‐site APP‐cleaving enzyme 2 (BACE2) expression is associated with increases in the grade of human glioma, the incidence of the mesenchymal molecular glioblastoma multiforme subtype and the likelihood of poor prognoses for patients. BACE2 knockdown suppressed cell invasion, cell migration and tumour growth both in vitro and in vivo, while BACE2 overexpression promoted the mesenchymal transition and cell proliferation. Furthermore, TGFβ1 stimulated BACE2 expression through Smad‐dependent signalling, which modulated TNF‐α‐induced NF‐κB activity through the PP1A/IKK pathway to promote tumorigenesis in both U87MG and U251 cells. Our study indicated that BACE2 plays a significant role in glioma development. Therefore, BACE2 is a potential therapeutic target for human gliomas due to its function and ability to be regulated.
Facile Fabrication of Porous Si Microspheres from Low‐Cost Precursors for High‐Capacity Electrode
Authors: Geng Liyuan , Yang Dandan , Gao Shilun , Zhang Zhaoxiang , Sun Feiyuan , Pan Yiyang , Li Shaoqi , Li Xiaohua , Cao Peng‐Fei , Yang Huabin 
Published: December 2019

AbstractComparing with nanometer‐sized Si (nano‐Si), the micrometer‐sized Si (micro‐Si) is more promising for the practical applications due to its low cost and scalable production method. Fabrication of micro‐Si with porous architecture can efficiently alleviate the high mechanical stress and severe mechanical fracture. Till now, it is still a challenge to achieve porous micro‐Si with controlled morphology, such as microsphere, from a cost‐efficient and environmentally friendly approach. Herein, a facile approach on fabricating Si microsphere with porous architecture via a low‐temperature aluminothermic reduction (LTAR) method using the low‐cost fumed silica (FS) as raw material is introduced. After compositing with graphite and then coating with amorphous carbon, the SiFS/graphite@carbon (SiFS/G@C) electrode displays superior reversible capacity (730 mAh g−1 after 100 cycles) and excellent rate capability (729.1 mAh g−1 at 1 A g−1). The electrochemical performance is much better than that of Si‐microparticles/G@C (Mic‐Si/G@C, 368 mAh g−1 at 100 mA g−1 after 100 cycles). These results show the great potential of SiFS/G@C electrode as an alternative high‐performance electrode material for lithium ion batteries. Moreover, the LTAR adopted in the current study significantly reduces the energy consumption for preparation of Si microspheres from low‐cost raw materials.