bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Samples Cannot Be Used for Fluorescence Immunoassay for detection of myocardial infarction triple
Authors: Xu Wanju , Gong Zhonghua , Yan Yan , Lv Shiyu , Wang Jiazheng 
Published: July 2020

Abstract
Background: Whole blood or plasma samples are recommended for use in triple-marker testing of myocardial infarction. Whether serum sample can be used for the diagnosis of myocardial infarction has not been compared and validated.Methods: Whole blood samples and serum samples were detected with CTnI, Mb and CK-MB simultaneously by using immunofluorescence assay method.Results: Both CK-MB and TNI detection results were highly consistent for whole blood samples vs. serum samples. However, when Mb is tested, the positive rate of serum samples is relatively low, and there will be more false negative results, resulting in missed diagnosis.Conlusion: Serum samples cannot be used in replace of whole blood samples for triple-marker testing and diagnosis of myocardial infarction.
Parabolic Trough Collector with Internal Fractal Fins in Receiver to Increase Thermal Performance in Working Fluid
Authors: Palacios Angelica , Amaya Dario , Ramos Olga 
Published: July 2020

Abstract
Concentrated solar power technologies have been studied in recent years as a potential solution for energy production industry , however this kind of systems face different challenges in order to increase thermal performance and efficiency. This paper presents the results of a thermal analysis on a parabolic trough collector with different receivers internal fins configurations, systems were studied in CFD Solidworks® flow simulation software and compared with a traditional parabolic collector with cylindrical receiver. Results shows that the lowest thermal performance was achieved with a cylindrical pipe, instead fractal fins receiver with 5 internal fins achieves a temperature increase of 27% and the best pipe configuration was fractal Descartes with 12 internal pipes which e the cylindrical temperature in 29%.
A prognostic five immune-related long noncoding RNA signature for patients with colon cancer
Authors: Zhao Kankan , Wang Mengchuan , Kang Houlong , Wu Aiguo 
Published: July 2020

Abstract
Background: Our study aimed to identify immune related long non-coding RNAs (LncRNAs) to serve as potential prognostic indicators and immune therapeutic targets in patients with colon cancer.Methods: The Cancer Genome Atlas (TCGA) and Molecular Signatures Databases (MSigDB) database were used to identify immune related lncRNAs in patients with colon cancer. The least absolute shrinkage and selection operator (LASSO) analysis, and multivariate Cox proportional hazards regression analysis were employed to screen prognostic lncRNAs and construct immune-related multi-lncRNA signature. We used time-dependent receiver operating characteristic curve to assess the performance of this signature in colon cancer by calculating the area under the curve (AUC). Univariate and multivariate Cox regression analysis were performed to verify the independence of the prognostic value of this signature in colon cancer.Results: Five immune related lncRNAs (AC025575.2, AL161729.4, ELFN1-AS1, LINC00513, MIR210HG) were found to be significantly associated with overall survival (OS) of patients with colon cancer. Then, we developed a five immune-related lncRNA signature. According to this signature, patients were ranked into a high risk group (n = 208) and a low risk group (n = 209). Kaplan-Meier curve and log-rank method showed that patients in high risk group had worse OS than patients in low risk group (P = 5.5644e-05). AUC for predicting 3 year survival and 5 year survival was 0.776 and 0.762 respectively, which indicated good performance of this signature. Finally, this five immune-related lncRNA signature was demonstrated to be independently associated with prognosis of patients with colon cancer.Conclusion: We developed a five immune-related lncRNA signature as a prognostic biomarker for patients with colon cancer.
Risk factors of pulmonary arterial hypertension in patients with systemic lupus erythematosus
Authors: Lei Yunxia , Zhang Xiao , Feng Yuan , Wang Jieying , Luo Riqiang 
Published: July 2020

Abstract
Introduction
: Pulmonary arterial hypertension (PAH) symptoms in systemic lupus erythematosus (SLE) patients are non-specific and early diagnosis and intervention are challenging. It remains essential to explore risk factors for PAH in SLE patients to identify high risk patients and allow intensive monitoring.
Methods
From January 2010 to December 2018, 84 patients with SLE and PAH and 160 patients with SLE but without PAH were enrolled. Clinical manifestations and laboratory test results were compared between the two groups to identify predictors of PAH. Candidate PAH risk factors were further compared among SLE-PAH patients with different characteristics.
Results
Among collected patient characteristics, Raynaud's phenomenon (OR 2.32, 95% CI: 1.17–4.61), digital vasculitis (OR 4.12, 95% CI: 1.48–11.49), pericardial effusion, pulmonary interstitial lesions, positive anti-U1RNP antibodies, and positive ACA-IgG were associated with significantly higher risk of PAH in SLE patients. Among these candidate risk factors, positive anti-U1RNP antibody was independently associated with severe PAH and more active disease. Digital vasculitis was independently associated with SLE alleviation, while pericardial effusion was associated with SLE deterioration. Pericardial effusion was associated with longer PAH duration.
Discussion
The significant association between studied clinical and laboratory indicators and risk of PAH, PAH and SLE characteristics suggested that these factors can be used to identify patients at higher risk of PAH and adverse outcomes. Close monitoring may be indicated in patients with these risk factors, especially with more than one risk factor.
Poly(ADP-Ribose) Polymerase Inhibitors (PARPi) for Patients With Advanced Breast Cancer: a Meta-analysis of Randomized Controlled Trials
Authors: Su YongCheng , Zheng XiaoGang 
Published: July 2020

Abstract
BACKGROUND: Poly(ADP–ribose) polymerase (PARP) inhibitors are new class of drugs that are currently being studied in several malignancies. However, datas about the efficacy and safety of the PARP inhibitors are limited. Therefore, we conducted a meta-analysis of randomized controlled trials (RCT) in patients with breast cancer.METHODS: Pubmed/Medline, Embase, Cochrane Library, and abstracts presented at the annual meeting of the American Society of Clinical Oncology (ASCO) were searched for articles published from 2000 to June 2018.Summary incidences and the RR, HR with 95% confidence intervals, were calculated by using a random-effects or fixed-effects model.RESULTS: The summary HR indicated PARPi was not associated with OS (HR=0.83, 95%CI 0.66–1.06, Z=1.49, P=0.14), while it could significantly improve PFS ande time to deterioration (TTD) of global health status/quality of life(GHS/QoL) as compared with traditional standard therapy, the HR was 0.60(95%CI 0.50-0.72; Z=5.52, P＜0.00001) and 0.4 (95%CI 0.29–0.54,z=5.80 ,p=0.000),respectively.The RR of grade 3 or more anemia ,fatigue and headache was 3.02 (95% CI, 0.69–13.17;p = 0.14,,I2=90%),0.77 (95%CI, 0.34–1.73;p=0.52,I2=7%) and 1.13 (95% CI,0.30–4.18;p=0.86,I2=0%),respectively.CONCLUSION: The findings of this meta-analysis showed that PARPi has no significant effect on OS, while it could significantly improve in PFS and TTD of GHS/QoL for patients with advanced or metastatic breast cancer.Furthermore,our findings also demonstrated that the PARPi treatment is connected with an increased risk of grade 3 or more anemia adverse events.
The Role of Body Mass Index in High and Low Velocity Trauma Causing Knee Injury Associated to Popliteal Artery Lesions.
Authors: Marchetti Andrea Ascoli , Naldi Valerio , Potenza Vito , Oddi Fabio Massimo , De Maio Ferdinando , Ciattaglia Riccardo , Farsetti Pasquale , Ippoliti Arnaldo 
Published: July 2020

Abstract

Background: Osteoarticular traumas are particularly dangerous among arterial traumas, those associated with the popliteal artery are associated with a high amputation rate. Despite representing a minority of arterial traumas, with an incidence that considerably varies by population and geographic location, traumatic lesions of the popliteal artery are a challenge. This study aimed to verify the impact of Body Mass Index (BMI) on arterial trauma damage and outcome. Methods: Data were retrospectively collected from the emergency and operating rooms’ electronic medical reports at our Institution between 1 January 2005 and 1 May 2018 of all osteoarticular and vascular associated lesion. 41 pts presented with lower limb arterial trauma (43.2%), and popliteal artery lesions occurred in 11 (26.8%). 11 patients were eligible for inclusion in the study. In addition, the lesion mechanism was dislocation by high-velocity trauma in 9 cases and by low-velocity trauma in 3. All 7 males (63.6%) were affected by high-velocity trauma, and 2 of the 3 females by low-velocity trauma. Only one patient had an isolated popliteal artery lesion associated with fractures in the leg or in contralateral limb. Patients with low-velocity traumas were older than 54 years while those with high-velocity were aged from 22 to 71 years. Results: The lesion mechanism was dislocation due to high-velocity trauma in eight patients and due to low-velocity trauma in three. In 10/11 patients (90.9%). revascularization was performed after osteoarticular stabilization. after reduction of the dislocation or fracture. Intraoperative angiography was selectively used. Two patients required above-knee amputation after the procedure: one due to infection of the surgical access and the other due to severe soft tissue injury. One patient died during hospitalization due to trauma-related complications and comorbidities. Conclusions: High-velocity traumas, and low-velocity traumas with a body mass index >35kg/m2 with knee lesions are associated with popliteal artery lesion. Revascularization success is not associated with high or low velocity traumas.
French hepatitis C care cascade: substantial impact of direct-acting antivirals, but the road to elimination is still long
Authors: Brouard Cécile , Pillonel Josiane , Boussac Marjorie , de Lédinghen Victor , Rachas Antoine , Silvain Christine , Lydié Nathalie , Chevaliez Stéphane , Pioche Corinne , Durand Julien , Lot Florence , Delarocque-Astagneau Elisabeth 
Published: July 2020

Abstract
Background: Hepatitis C virus (HCV) elimination by 2030, as targeted by the World Health Organization (WHO), requires that 90% of people with chronic infection be diagnosed and 80% treated. We estimated the cascade of care (CoC) for chronic HCV infection in mainland France in 2011 and 2016, before and after the introduction of direct-acting antivirals (DAAs).Methods: The numbers of people (1) with chronic HCV infection, (2) aware of their infection, (3) receiving care for HCV and (4) on antiviral treatment, were estimated for 2011 and 2016. Estimates for 1) and 2) were based on modelling studies for 2011 and on a virological sub-study nested in a national cross-sectional survey among the general population for 2016. Estimates for 3) and 4) were made using the National Health Data System.Results: Between 2011 and 2016, the number of people with chronic HCV infection decreased by 31%, from 192,700 (95% Credibility interval: 150,900-246,100) to 133,500 (95% Confidence interval: 56,900-312,600). The proportion of people aware of their infection rose from 57.7% to 80.6%. The number of people receiving care for HCV increased by 22.5% (representing 25.7% of those infected in 2016), while the number of people on treatment increased by 24.6% (representing 12.1% of those infected in 2016).Conclusions: This study suggests that DAAs substantially impact CoC. However, access to care and treatment for infected people remained insufficient in 2016. Updating CoC estimates will help to assess the impact of new measures implemented since 2016 as part of the goal to eliminate HCV.
Fetal sex and maternal postpartum depressive symptoms: findings from two prospective pregnancy cohorts
Authors: Cowell Whitney , Colicino Elena , Askowitz Talia , Nenton Farida , Wright Rosalind 
Published: July 2020

Abstract
Background: Fetal sex is known to modify the course and complications of pregnancy, with recent evidence of sex-differential fetal influences on the maternal immune and endocrine systems. In turn, heightened inflammation and surges in reproductive hormone levels associated with pregnancy and parturition have been linked with the development of perinatal depression. Here, we examined whether there is an association between fetal sex and maternal depression assessed during the prenatal and postnatal periods.Methods: The study included two multi-ethnic, prospective pregnancy cohorts that enrolled women from prenatal clinics in the Northeastern United States between 2001 and 2018. Maternal depressive symptoms were measured during the prenatal and postnatal periods using the Edinburgh Postpartum Depression Scale (EPDS) and newborn sex was reported by the mother following delivery. We used logistic regression to examine associations between fetal sex and maternal depressive symptoms (EPDS>10) during the prenatal period only, postnatal period only, or both periods versus no depressive symptoms during either period. We considered both unadjusted models and models adjusted for a core set of sociodemographic and lifestyle variables. Results: In adjusted models conducted using PRISM data (N=528), women pregnant with a male versus female fetus had significantly greater odds of depressive symptoms during the postnatal period compared to women without depressive symptoms during either period (odds ratio [OR] = 5.24, 95% confidence interval [CI] = 1.93, 14.21). The direction of results was consistent in the ACCESS cohort, although the findings did not reach statistical significance (OR = 2.05, 95% CI = 0.86, 4.93). Significant associations were not observed in either cohort among women with prenatal symptoms only or women with prenatal and postnatal symptoms. Conclusions: Male fetal sex was associated with the onset of depressive symptoms during the postnatal period.
An Observational Study of the Impact of COVID-19 and the Transition to Telehealth on Community Mental Health Center Providers
Authors: Sklar Marisa , Reeder Kendal , Carandang Kristine , Ehrhart Mark G , Aarons Gregory A 
Published: July 2020

Abstract
Background: The COVID-19 pandemic has swiftly and remarkably altered community mental health service delivery and evidence-based practice (EBP) implementation. This study reports provider perspectives on the impact that COVID-19 had on their work and EBP implementation. Methods: Providers (n = 93) completed online surveys with quantitative measures and open-ended items targeting their responses and/or reactions to COVID-19, and to the transition to providing services via telehealth.Results: Perceptions of personal risk and rumination around COVID-19 were low, while telehealth was viewed positively by providers. Three major themes emerged regarding the major impacts of COVID-19 on work: 1) the altered nature of interactions between patient/client and provider, 2) changes in provider expectations regarding productivity, and 3) challenges maintaining work-life balance. In regard to the major impacts of COVID-19 on EBP implementation, three themes emerged: 1) increased difficulty delivering certain therapies via telehealth, 2) potential limitations to session confidentiality, and 3) challenge of engaging children in telehealth. Conclusions: In the context of the COVID-19 pandemic, community mental health providers continued to engage with clients and implement EBPs while navigating a number of changes related to the transition to telehealth. This study highlights the need for further work on what supports providers need to effectively engage with clients and deliver EBPs via telehealth and has implications for how telehealth is sustained or de-implemented in response to COVID-19.
Improved performances of lithium disilicate glass-ceramics by seeds induced crystallization
Authors: Zhao Ting , Lian Mei-Mei , Qin Yi , Zhu Jian-Feng , Kong Xin-Gang , Yang Jian-Feng 
Published: July 2020

Abstract
Self-reinforced lithium disilicate (Li 2 Si 2 O 5 ) glass-ceramics were hot pressing sintered by introducing 5 wt% Li 2 Si 2 O 5 crystal seeds into two different glass systems. The results show that the seeds play an important role in the crystallization inducement, microstructural and properties improvement of the glass, especially for the glass powder without the nucleating agent of P 2 O 5 . The microstructure features a wider bimodal grain size distribution with large rod-like crystals epitaxially grown along the seeds and small crystals nucleated from the glass powder itself, contributes to the improvement of the performance especially the fracture toughness. The 4C5S specimen exhibited the best comprehensive properties with a good flexural strength (396 ± 7 MPa), improved fracture toughness (3.31 ± 0.19 MPa·m 1/2 ) and comparable translucency as IPS e.max. This research will provide a new idea and method for the perfect matching of the fracture toughness and the aesthetic appearance of lithium disilicate glass-ceramics, and lay the foundation for its clinical applications.
The Asymptomatic Infection of COVID-19 Risen in Imported Population in Shenzhen, China
Authors: Chen Mu-Xin , Ai Lin , Huang Da-Na , Feng Tie-Jian , Chen Jia-Xu , Mei Shu-Jiang , Huang Ya-Lan , Sun Ying , Meng Jun , Yang Gai-Ge , Xiong Ling-Hong , Zhang Xiao-Min , Peng Bo , Fang Shi-Song , Zhang Shun-Xian , Zhang Ren-Li 
Published: July 2020

Abstract
Background

As of July 24 2020, the global reported number of COVID-19 cases was > 15.4 millions, with over 640,000 deaths. The present study aimed to carry out an epidemiological analysis of confirmed cases and asymptomatic infections in Shenzhen City to provide scientific reference for the prevention and control of COVID-19.
Methods

The epidemiological information of the 462 confirmed cases and 45 asymptomatic infections from January 19th to June 30th was collected in Shenzhen City, Southern China, and a descriptive analysis was performed.
Results

A total of 462 confirmed COVID-19 cases from January 19 to April 30, 2020 were reported in Shenzhen City, including 423 domestic cases (91.56%) and 39 imported cases (8.44%) who came back from other countries. Among domestic cases, the majority were cases imported from Hubei Province (n = 312, 67.53%), followed by local ones (n = 69, 14.94%). During the same period, a total of 45 asymptomatic infections were reported in Shenzhen City, including 31 local ones (68.89%) and 14 imported from abroad (31.11%). The proportion of asymptomatic infections in Shenzhen City was increasing over time (Z = 13.1888, P < 0.0001). The total number of local asymptomatic infections in Shenzhen City exceeded as the same pattern as that in other provinces (χ2 = 118.830, P < 0.0001). The proportion of asymptomatic infections among cases imported from abroad was higher than that of the same in domestic cases (χ2 = 22.5121, P < 0.0001, OR = 4.8983, 95%: 2.4052, 9.9756). No statistical significance was noted in the proportions of asymptomatic infections among imported cases from different countries (χ2 = 7.7202, P = 0.6561).
Conclusions

The majority of COVID-19 cases in Shenzhen City were imported cases who came back from Hubei Province in the early stage (before 1st March, 2020) and from abroad in the later stage (after 1st April, 2020). Scientific and effective prevention and control measures have resulted in only a few local infections in Shenzhen City. Asymptomatic infections accounted for an increasing proportion among cases imported from abroad, indicating that the prevention measures carried out in Shenzhen City did avoid the import of infected cases. Improving the detection capability to identify asymptomatic infections as early as possible will be of significance for the control outbreak of COVID-19.
Effects Of Orally Administered Recombinant Lactobacillus Casei Expressing HN Protein On Early Growth Performance, Intestinal Health And Protection Against NDV Challenge In Chickens
Authors: Ju Anqi , Duan Aoyi , Zhang Yingnan , Qin Yanjun , Xue Ligang , Ma Xin , Luan Weimin , Yang Shubao 
Published: July 2020

Abstract
Backgroud: Newcastle disease virus (NDV) is considered one of the most important diseases among chickens. In this study, we generated recombinant surface-displayed Lactobacillus casei (L.casei) expressing the hemagglutinin-neuraminidase (HN) of NDV and a live vector pPG alone (named Lc-pPG-HN and Lc-pPG), and evaluated their effects on early growth development, intestinal health and protection against NDV challenge in chickens. 270 chickens were randomly divided into three groups: Lc-pPG-HN, Lc-pPG and physiological saline (control) group, and chickens from each group were respectively immunized with Lc-pPG-HN, Lc-pPG and physiological saline on 1 and 10 days. Results: Recombinant L.casei expressing the HN protein of NDV (Lc-pPG-HN) was successfully constructed. Orally immunized with Lc-pPG-HN could significantly increase body weight (BW) and immune organs index. Moreover, Lc-pPG-HN improved secretory immunoglobulin A (SIgA) in jejunum, the relative abundance of flora in cecum, histomorphological development of small intestine. In addition, the similar enhancement effects were also observed with hemaggluti-nation inhibition (HI) antibody titer and the expression of cytokines in the serum. The oral administration of Lc-pPG-HN also provided effective protection and alleviated the symptoms of NDV challenge.Conclusions: Thus, a recombinant L.casei vaccine expressing HN may be a potential therapeutic candidate against NDV and improve chickens growth and development.