bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence, Machine Learning and Calculation of Intraocular Lens Power
Authors: Langenbucher Achim , Szentmáry Nóra , Wendelstein Jascha , Hoffmann Peter 
Published: November 2020

Abstract
Background and Purpose In the last decade, artificial intelligence and machine learning algorithms have been more and more established for the screening and detection of diseases and pathologies, as well as for describing interactions between measures where classical methods are too complex or fail. The purpose of this paper is to model the measured postoperative position of an intraocular lens implant after cataract surgery, based on preoperatively assessed biometric effect sizes using techniques of machine learning.
Patients and Methods In this study, we enrolled 249 eyes of patients who underwent elective cataract surgery at Augenklinik Castrop-Rauxel. Eyes were measured preoperatively with the IOLMaster 700 (Carl Zeiss Meditec), as well as preoperatively and postoperatively with the Casia 2 OCT (Tomey). Based on preoperative effect sizes axial length, corneal thickness, internal anterior chamber depth, thickness of the crystalline lens, mean corneal radius and corneal diameter a selection of 17 machine learning algorithms were tested for prediction performance for calculation of internal anterior chamber depth (AQD_post) and axial position of equatorial plane of the lens in the pseudophakic eye (LEQ_post).
Results The 17 machine learning algorithms (out of 4 families) varied in root mean squared/mean absolute prediction error between 0.187/0.139 mm and 0.255/0.204 mm (AQD_post) and 0.183/0.135 mm and 0.253/0.206 mm (LEQ_post), using 5-fold cross validation techniques. The Gaussian Process Regression Model using an exponential kernel showed the best performance in terms of root mean squared error for prediction of AQDpost and LEQpost. If the entire dataset is used (without splitting for training and validation data), comparison of a simple multivariate linear regression model vs. the algorithm with the best performance showed a root mean squared prediction error for AQD_post/LEQ_post with 0.188/0.187 mm vs. the best performance Gaussian Process Regression Model with 0.166/0.159 mm.
Conclusion In this paper we wanted to show the principles of supervised machine learning applied to prediction of the measured physical postoperative axial position of the intraocular lenses. Based on our limited data pool and the algorithms used in our setting, the benefit of machine learning algorithms seems to be limited compared to a standard multivariate regression model.
Resection of Foramen Magnum Meningioma through Modified Far Lateral Approach: Surgical Principles and Technical Nuances
Authors: Narayan Vinayak , Jumah Fareed , Nanda Anil 
Published: November 2020

Abstract
Objectives Safe maximal resection is the basic principle of cranial base surgery and the grade of resection is an important factor influencing the prognostic outcome. This operative video highlights the surgical principles and technical nuances in the microsurgical resection of foramen magnum meningioma (FMM).
Case Description The surgery was performed in a 45-year-old lady who presented with hoarseness of voice and spastic quadriparesis (grade 4/5). On imaging, FMM with mass effect on brainstem and spinal cord was identified. The tumor was gross totally resected through modified far lateral approach with minimal occipital condyle drilling. This video demonstrates the surgical techniques of tumor resection including early devascularization, operating in the arachnoid plane to dissect the neurovascular structures, piecemeal decompression, sharp dissection to separate tumor from lower cranial nerves (LCN), identifying the brainstem veins, and resecting the lesion from tumor–brainstem interface. Postoperatively, she had significant neurological improvement and the magnetic resonance imaging revealed excellent radiological outcome (Figs. 1 and 2).
Conclusion The surgery of FMM is challenging due to the deep surgical corridor, critical location, close proximity with various neurovascular structures, firm consistency, and high vascularity of the tumor. The modified far lateral approach by preserving the occipital condyle may prevent the postoperative incidence of craniovertebral junction instability. The key operative principles to achieve the best surgical outcome include careful dissection along the arachnoid plane, gentle handling of cranial nerves, veins, and perforator vessels, avoidance of traction on brainstem and spinal cord, intraoperative neurophysiological monitoring, proper hemostasis, and meticulous dural closure.The link to the video can be found at: https://youtu.be/1qvAeUmNIUw.
Thiamine Pyrophosphokinase Deficiency due to Mutations in the TPK1 Gene: A Rare, Treatable Neurodegenerative Disorder
Authors: Rüsch Christina T. , Wortmann Saskia B. , Kovacs-Nagy Reka , Grehten Patrice , Häberle Johannes , Latal Beatrice , Stettner Georg M. 
Published: November 2020

AbstractTPK deficiency due to TPK1 mutations is a rare neurodegenerative disorder, also known as thiamine metabolism dysfunction syndrome 5 (OMIM no.: 614458). Here, we report a new patient with compound heterozygous TPK1 mutations, of which one has not been described so far. The individual reported here suffered from acute onset encephalopathy, ataxia, muscle hypotonia, and regression of developmental milestones in early infancy, repeatedly triggered by febrile infections. Initiation of high-dose thiamine and magnesium supplementation led to a marked and sustained improvement of alertness, ataxia, and muscle tone within days. Contrary to the described natural history of patients with TPK deficiency, the disease course was favorable under thiamine treatment without deterioration or developmental regression during the follow-up period. TPK deficiency is a severe neurodegenerative disease. This case report demonstrates that this condition is potentially treatable. High-dose thiamine treatment should therefore be initiated immediately after diagnosis or even upon suspicion.
Reconstruction of the Distal Oblique Bundle of the Interosseous Membrane with Extensor Carpi Radialis Hemitendon: A New Minimally-Invasive Technique
Authors: Martínez-Martínez Francisco , Giménez-Ros Alberto , León-Muñoz Vicente J. , Santonja-Medina Fernando 
Published: November 2020

AbstractThe main stabilizing element of the distal radioulnar joint (DRUJ) is the triangular fibrocartilage complex (TFCC). Secondary stabilizers include the distal oblique band (DOB), which is inconsistently found. When TFCC repair has failed or cannot be performed, DOB reconstruction is a therapeutic option. Even though distal radioulnar ligamentoplasty remains the technique of choice, recent papers show similar outcomes from both methods. We present two cases of successful DOB repair with the extensor carpi radialis longus (ECRL) hemitendon.
An Exploratory Study of Cognitive Functioning and Psychological Well-Being in Middle-Aged Adults with Diabetes Mellitus
Authors: Halder Susmita , Samajdar Shinjini , Mahato Akash Kumar 
Published: November 2020

Abstract
Background Diabetes mellitus is a chronic metabolic disorder characterized by increased level of blood sugar for a prolonged period of time. Apart from its impact on the bodily functions, the disorder has its own psychological consequences, commonly in terms of stress reaction, anxiety, and depression. Diabetes is also known to affect cognitive functions, but it is less studied in the Indian population and relatively ignored in the management plan. Discerning the cognitive functions in middle-aged adults diagnosed with diabetes can give valuable insight into comprehensive management of the disorder. With this background, the study attempted to explore the cognitive functioning and psychological well-being of middle-aged adults with diabetes and compared with healthy individuals.
Methods A total of 30 middle-aged adults of both sexes diagnosed with diabetes type 2 were undertaken for the study and compared with 30 healthy adults regarding measures of cognitive functioning and psychological well-being. The measures were also explored for relationship if any with illness duration.
Results Middle-aged adults with diabetes differed significantly in terms of response inhibition and processing speed compared with healthy controls. The groups significantly differed on subjective Psychological well-being in terms of self-control, anxiety and depression, and vitality. Duration of illness was found to be related to anxiety symptoms.
Conclusion Diabetes affects response inhibition and processing speed in middle-aged adults. Assessing and addressing impairment in cognitive functions is recommended for a comprehensive management of diabetes in middle-aged adults.
In Vitro activity of a Novel Benzoquinolizine Antibiotic, Levonadifloxacin (WCK 771) against Blood Stream Gram-Positive Isolates from a Tertiary Care Hospital
Authors: Mamtora Dhruv , Saseedharan Sanjith , Rampal Ritika , Joshi Prashant , Bhalekar Pallavi , Ahdal Jaishid , Jain Rishi 
Published: November 2020

AbstractBackground Blood stream infections (BSIs) due to Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are associated with high mortality ranging from 10 to 60%. The current anti-MRSA agents have limitations with regards to safety and tolerability profile which limits their prolonged usage. Levonadifloxacin and its oral prodrug alalevonadifloxacin, a novel benzoquinolizine antibiotic, have recently been approved for acute bacterial skin and skin structure infections including diabetic foot infections and concurrent bacteremia in India.Methods The present study assessed the potency of levonadifloxacin, a novel benzoquinolizine antibiotic, against Gram-positive blood stream clinical isolates (n = 31) collected from January to June 2019 at a tertiary care hospital in Mumbai, India. The susceptibility of isolates to antibacterial agents was defined following the Clinical and Laboratory Standard Institute interpretive criteria (M100 E29).Results High prevalence of MRSA (62.5%), quinolone-resistant Staphylococcus aureus (QRSA) (87.5%), and methicillin-resistant coagulase-negative staphylococci (MR-CoNS) (82.35%) were observed among bacteremic isolates. Levonadifloxacin demonstrated potent activity against MRSA, QRSA, and MR-CoNS strains with significantly lower minimum inhibitory concentration MIC50/90 values of 0.5/1 mg/L as compared with levofloxacin (8/32 mg/L) and moxifloxacin (2/8 mg/L).Conclusion Potent bactericidal activity coupled with low MICs support usage of levonadifloxacin for the management of BSIs caused by multidrug resistant Gram-positive bacteria.
Update on the Use of Arthroscopy in Kienböck's Disease Management
Authors: Aguilera René Jorquera , Sanhueza Camila Azócar 
Published: November 2020

AbstractKienböck's disease is a clinical-radiological condition that can permanently affect wrist functionality and the patient's quality of life. Proper, pertinent diagnosis and treatment are required to avoid salvage procedures. Arthroscopic techniques have emerged as an important tool for the treatment of certain stages of the disease.We present a review of the literature and propose a treatment algorithm according to the stage of the disease, including arthroscopic techniques. We detail the surgical technique of arthroscopic scaphocapitate arthrodesis, and the functional outcomes obtained by our group.
High Tibial Osteotomy with a Modern Polyetheretherketone (PEEK) System: Mid-Term Results at a Mean of 6 Years Follow-Up
Authors: Keyt Lucas K. , Hevesi Mario , Levy Bruce A. , Krych Aaron J. , Camp Christopher L. , Stuart Michael J. 
Published: November 2020

AbstractThe purpose of this study was to determine patient-reported outcomes, hardware removal rates, as well as conversion to arthroplasty at mid-term follow-up following high tibial osteotomy (HTO) with a modern polyetheretherketone (PEEK) system. All PEEK system-based HTOs performed at a single institution between January 2010 and January 2016 with a minimum of 2 years follow-up were reviewed. Rates of postoperative complications, hardware removal and conversion to arthroplasty were calculated. Patient-reported outcomes including visual analog pain scale (VAS), Tegner activity scale, Lysholm, Knee Injury and Osteoarthritis Outcome Score (KOOS), and 36-Item Short Form Survey (SF-36) were obtained. Forty-seven HTOs in 43 patients (mean age: 37.6 ± 10.8 years; 30 M, 13 F) were followed for a mean of 6.0 ± 1.5 years. A total of four postoperative complications occurred in three patients, resulting in an overall complication rate of 6.4%. Hardware removal occurred in three patients at a mean of 0.73 ± 0.53 years after surgery, with overall survival free of hardware removal of 96% (95% confidence interval [CI]: 85–99) at 1 year, 94% (95% CI: 82–98) at 2 years, and 94% (95% CI: 82–98) at 8 years. Conversion to arthroplasty occurred in three patients at a mean of 3.2 ± 1.0 years after surgery, with mean survival of 100% (95% CI: 94–100) at 1 year, 100% (95% CI: 94–100) at 2 years, and 93% (95% CI: 81–98) at 8 years. VAS at rest improved, from 3.1 ± 2.5 preoperatively to 1.1 ± 1.6 postoperatively (p < 0.001). Patients remained active, with a mean Tegner activity scale of 4.4 ± 1.4 at final follow-up and satisfactory Lysholm, KOOS, and SF-36 scores. At mid-term follow-up, medial opening-wedge HTO using a modern PEEK-based system was found to be safe, efficacious, and durable, with satisfactory outcome scores and a low rate of conversion to arthroplasty. PEEK-based implants were found to have low hardware removal rates of 6% at 5 years, which compares favorably to historic metal fixation. This is a Level III study.
Isolated Liner Revision for Total Knee Arthroplasty Instability: A Road That Should Remain Less Taken
Authors: Tegethoff Jason D. , Walker-Santiago Rafael , Ralston William M. , Keeney James A. 
Published: November 2020

AbstractIsolated polyethylene liner exchange (IPLE) is infrequently selected as a treatment approach for patients with primary total knee arthroplasty (TKA) prosthetic joint instability. Potential advantages of less immediate surgical morbidity, faster recovery, and lower procedural cost need to be measured against reoperation and re-revision risk. Few published studies have directly compared IPLE with combined tibial and femoral component revision to treat patients with primary TKA instability. After obtaining institutional review board (IRB) approval, we performed a retrospective comparison of 20 patients treated with IPLE and 126 patients treated with tibial and femoral component revisions at a single institution between 2011 and 2018. Patient demographic characteristics, medical comorbidities, time to initial revision TKA, and reoperation (90 days, <2 years, and >2 years) were assessed using paired Student's t-test or Fisher's exact test with a p-value <0.01 used to determine significance. Patients undergoing IPLE were more likely to undergo reoperation (60.0 vs. 17.5%, p = 0.001), component revision surgery (45.0 vs. 8.7%, p = 0.002), and component revision within 2 years (30.0 vs. 1.6%, p < 0.0001). Differences in 90-day reoperation (p = 0.14) and revision >2 years (p = 0.19) were not significant. Reoperation for instability (30.0 vs. 4.0%, p < 0.001) and infection (20.0 vs. 1.6%, p < 0.01) were both higher in the IPLE group. IPLE does not provide consistent benefits for patients undergoing TKA revision for instability. Considerations for lower immediate postoperative morbidity and cost need to be carefully measured against long-term consequences of reoperation, delayed component revision, and increased long-term costs of multiple surgical procedures. This is a level III, case–control study.
Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report
Authors: Ekwere Timothy Amos , Eziagu Uchechukwu Brian 
Published: November 2020

AbstractCastleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.
The Role of Oocyte Quality in Explaining “Unexplained” Infertility
Authors: Homer Hayden Anthony 
Published: November 2020

AbstractInfertility is described as unexplained when pregnancy does not occur despite ovulation, patent Fallopian tubes, and normal semen parameters. Oocyte developmental competence (or quality) is rate-limiting for pregnancy success as oocytes provide virtually all the cellular building blocks including mitochondria required during embryogenesis. However, available tests estimate oocyte numbers (anti-Müllerian hormone, follicle-stimulating hormone and antral follicle count) and ovulation (luteal phase serum progesterone) but not the third, and most pivotal, oocyte-specific parameter, quality. Severe depletion of the follicular reserve manifests as premature ovarian insufficiency and is an obvious cause of anovulation with overt symptoms and clear diagnostic criteria. In contrast, there are no biomarkers of poor oocyte quality other than through in vitro fertilization when readouts of oocyte quality such as preimplantation embryo development can be assessed. The most common cause of poor oocyte quality is natural aging, which is strongly tied to reduced oocyte mitochondrial efficiency and increased oxidative stress. In younger women, quality may also be impaired due to accelerated aging or sporadic genetic mutations which cause severe defects during oocyte and embryo development. Thus, poor oocyte quality often provides an explanation for infertility, but because it cannot be measured using conventional tests, many cases of infertility are often incorrectly labeled “unexplained.” Since female age remains the best predictor of oocyte quality, age over 37 years should be considered an independent diagnostic criterion.
The ironies of autonomy
Authors: Ganesh Maya Indira 
Published: November 2020

AbstractCurrent research on autonomous vehicles tends to focus on making them safer through policies to manage innovation, and integration into existing urban and mobility systems. This article takes social, cultural and philosophical approaches instead, critically appraising how human subjectivity, and human-machine relations, are shifting and changing through the application of big data and algorithmic techniques to the automation of driving. 20th century approaches to safety engineering and automation—be it in an airplane or automobile-have sought to either erase the human because she is error-prone and inefficient; have design compensate for the limits of the human; or at least mould human into machine through an assessment of the complementary competencies of each. The ‘irony of automation’ is an observation of the tensions emerging therein; for example, that the computationally superior and efficient machine actually needs human operators to ensure that it is working effectively; and that the human is inevitably held accountable for errors, even if the machine is more efficient or accurate. With the emergence of the autonomous vehicle (AV) as simultaneously AI/ ‘robot’, and automobile, and distributed, big data infrastructural platform, these beliefs about human and machine are dissolving into what I refer to as the ironies of autonomy. For example, recent AV crashes suggest that human operators cannot intervene in the statistical operations underlying automated decision-making in machine learning, but are expected to. And that while AVs promise ‘freedom’, human time, work, and bodies are threaded into, and surveilled by, data infrastructures, and re-shaped by its information flows. The shift that occurs is that human subjectivity has socio-economic and legal implications and is not about fixed attributes of human and machine fitting into each other. Drawing on Postphenomenological concepts of embodiment and instrumentation, and excerpts from fieldwork, this article argues that the emergence of AVs in society prompts a rethinking of the multiple relationalities that constitute humanity through machines.
Human–dog relationships during the COVID-19 pandemic: booming dog adoption during social isolation
Authors: Morgan Liat , Protopopova Alexandra , Birkler Rune Isak Dupont , Itin-Shwartz Beata , Sutton Gila Abells , Gamliel Alexandra , Yakobson Boris , Raz Tal 
Published: November 2020

AbstractThe recent COVID-19 pandemic led to uncertainty and severe health and economic concerns. Previous studies indicated that owning a companion animal, such as a dog or a cat, has benefits for good mental health. Interactions with animals may help with depression and anxiety, particularly under stress-prone conditions. Human–animal interactions may even improve peer-to-peer social relationships, as well as enhance feelings of respect, trust, and empathy between people. Interestingly, it has also been shown that stress and poor well-being of dog owners negatively affect the well-being of their companion animals. However, a dramatic increase in dog abandonment could potentially occur due to COVID-19 related health, economic and social stresses, as well as due to the inconclusive reports of companion animals being potential COVID-19 carriers. Such a scenario may lead to high costs and considerable public health risks. Accordingly, we hypothesized that the COVID-19 pandemic, and the related social isolation, might lead to dramatic changes in human–dog bidirectional relationships. Using unique prospective and retrospective datasets, our objectives were to investigate how people perceived and acted during the COVID-19 pandemic social isolation, in regards to dog adoption and abandonment; and to examine the bidirectional relationship between the well-being of dog owners and that of their dogs. Overall, according to our analysis, as the social isolation became more stringent during the pandemic, the interest in dog adoption and the adoption rate increased significantly, while abandonment did not change. Moreover, there was a clear association between an individual’s impaired quality of life and their perceptions of a parallel deterioration in the quality of life of their dogs and reports of new behavioral problems. As humans and dogs are both social animals, these findings suggest potential benefits of the human–dog relationships during the COVID-19 pandemic, in accordance with the One Welfare approach that implies that there is a bidirectional connection between the welfare and health of humans and non-human animals. As our climate continues to change, more disasters including pandemics will likely occur, highlighting the importance of research into crisis-driven changes in human–animal relationships.