bluuebunny/crossref_metadata_2025_split huggingface dataset:
When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia
Authors: Bertoux Maxime , Duclos Harmony , Caillaud Marie , Segobin Shailendra , Merck Catherine , de La Sayette Vincent , Belliard Serge , Desgranges Béatrice , Eustache Francis , Laisney Mickaël 
Published: August 2020

Abstract
The most recent theories of emotions have postulated that their expression and recognition depend on acquired conceptual knowledge. In other words, the conceptual knowledge derived from prior experiences guide our ability to make sense of such emotions. However, clear evidence is still lacking to contradict more traditional theories, considering emotions as innate, distinct and universal physiological states. In addition, whether valence processing (i.e. recognition of the pleasant/unpleasant character of emotions) also relies on semantic knowledge is yet to be determined. To investigate the contribution of semantic knowledge to facial emotion recognition and valence processing, we conducted a behavioural and neuroimaging study in 20 controls and 16 patients with the semantic variant of primary progressive aphasia, a neurodegenerative disease that is prototypical of semantic memory impairment, and in which an emotion recognition deficit has already been described. We assessed participants’ knowledge of emotion concepts and recognition of 10 basic (e.g. anger) or self-conscious (e.g. embarrassment) facial emotional expressions presented both statically (images) and dynamically (videos). All participants also underwent a brain MRI. Group comparisons revealed deficits in both emotion concept knowledge and emotion recognition in patients, independently of type of emotion and presentation. These measures were significantly correlated with each other in patients and with semantic fluency in patients and controls. Neuroimaging analyses showed that both emotion recognition and emotion conceptual knowledge were correlated with reduced grey matter density in similar areas within frontal ventral, temporal, insular and striatal regions, together with white fibre degeneration in tracts connecting frontal regions with each other as well as with temporal regions. We then performed a qualitative analysis of responses made during the facial emotion recognition task, by delineating valence errors (when one emotion was mistaken for another of a different valence), from other errors made during the emotion recognition test. We found that patients made more valence errors. The number of valence errors correlated with emotion conceptual knowledge as well as with reduced grey matter volume in brain regions already retrieved to correlate with this score. Specificity analyses allowed us to conclude that this cognitive relationship and anatomical overlap were not mediated by a general effect of disease severity. Our findings suggest that semantic knowledge guides the recognition of emotions and is also involved in valence processing. Our study supports a constructionist view of emotion recognition and valence processing, and could help to refine current theories on the interweaving of semantic knowledge and emotion processing.
Neoliberalism From Above and Cosmopolitanism From Below: A Korean-English Meetup Group in the United States
Authors: Curran Nathaniel Ming 
Published: August 2020

Abstract
This article applies theories of cosmopolitanism-from-below A. Appadurai (2011), F. Kurasawa (2004) to an empirical case. Drawing on participant-observation and interviews conducted over the course of 20 months at a Korean-English Meetup group in the United States, this article explores the practices of an explicitly “cosmopolitan” group. Specifically, it focuses on U.S. Americans and Korean interns, and considers their experiences and motivations within the broader structures of neoliberalism. The group is identified as alternately exemplifying and challenging neoliberal logic and the article considers the relationship between neoliberalism and different forms of cosmopolitanism. The cosmopolitan ethos fostered by the group’s founder and reinforced through members’ practice offers preliminary but hopeful evidence of a cosmopolitanism that challenges neoliberalism and the uneven distribution of cultural/economic capital.
Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex
Authors: Bird A D , Deters L H , Cuntz H 
Published: August 2020

Abstract
The connectivity of cortical microcircuits is a major determinant of brain function; defining how activity propagates between different cell types is key to scaling our understanding of individual neuronal behavior to encompass functional networks. Furthermore, the integration of synaptic currents within a dendrite depends on the spatial organization of inputs, both excitatory and inhibitory. We identify a simple equation to estimate the number of potential anatomical contacts between neurons; finding a linear increase in potential connectivity with cable length and maximum spine length, and a decrease with overlapping volume. This enables us to predict the mean number of candidate synapses for reconstructed cells, including those realistically arranged. We identify an excess of potential local connections in mature cortical data, with densities of neurite higher than is necessary to reliably ensure the possible implementation of any given axo-dendritic connection. We show that the number of local potential contacts allows specific innervation of distinct dendritic compartments.
Results From 2 Cohort Studies in Central Africa Show That Clearance of Wuchereria bancrofti Infection After Repeated Rounds of Mass Drug Administration With Albendazole Alone Is Closely Linked to Individual Adherence
Authors: Campillo Jérémy T , Awaca-Uvon Naomi P , Missamou Francois , Tambwe Jean-Paul , Kuyangisa-Simuna Godefroy , Weil Gary J , Louya Frédéric , Boussinesq Michel , Pion Sébastien D S , Chesnais Cédric B 
Published: August 2020

Abstract

Background
Two community trials conducted from 2012 to 2018 in the Republic of Congo and the Democratic Republic of the Congo demonstrated the efficacy of semiannual mass drug administration (MDA) with albendazole (ALB) alone on lymphatic filariasis (LF). However, a high interindividual heterogeneity in the clearance of infection was observed.

Methods
We analyzed trial data to assess the effect of individual adherence to ALB MDA on clearance of circulating filarial antigenemia (CFA) and microfilaremia. Community residents were offered a single dose of ALB every 6 months and tested for LF with a rapid test for CFA at baseline and then annually. CFA test results were scored on a semiquantitative scale. At each round, microfilaremia was assessed in CFA-positive individuals. All CFA-positive individuals for whom at least 1 follow-up measure was available were included in the analyses. Parametric survival models were used to assess the influence of treatment adherence on LF infection indicators.

Results
Of 2658 individuals enrolled in the trials, 394 and 129 were eligible for analysis of CFA and microfilaremia clearance, respectively. After adjusting for age, sex, and initial CFA score, the predicted mean time for clearing CFA was shorter in persons who had taken 2 doses of ALB per year (3.9 years) than in persons who had taken 1 or 0 dose (4.4 and 5.3 years; P &lt; .001 for both). A similar pattern was observed for microfilaremia clearance.

Conclusions
These results demonstrate a clear dose-response relationship for the effect of ALB on clearance of CFA and microfilaremia.
ARRHYTHMIAS, PACING, ABLATIONC1 A DEPENDENT SYNCOPE
Authors: Pitruzzella V , Sidoti P , Frenda A , Catalano C , Geraci S , Caramanno G 
Published: August 2020

Abstract
A 33-year-old man, ex drug addict on methadone therapy. He arrives to emergency department for syncope, reported by his wife reversion of the eyeballs and fine tremors with subsequent recovery of consciousness. A similar episode had happened a year ago. It was performed ECG: sinus bradycardia , 45 bpm, QT 600 msec, QTc 554 msec . Neurological examination performed: no motor deficits, negative Romberg. At brain CT no parenchymal tomodensitometric changes. Median line structures in axis. At the EEG: slight diffuse slow intercritical changes. Prescribed therapy with levetiracetam 500 mg. Cardiological examination and echocardiogram performed within the limits. Laboratory tests showed Trop HS 80 pg / ml. On the basis of the ECG and the slight increase of the troponin he was hospitalized in Cardiology and monitored. The following day, cardiac arrest due to torsade de pointes degenerated into ventricular fibrillation, DC shock was performed with the restoration of electrical and mechanical activity. Urgent coronary angiography was performed with evidence of coronary artery free from angiographically significant stenosis. SERT has been contacted: the patient had not been treated by them for some time and was using excessive doses of self-procuring methadone. In consideration of cardiac arrest from methadone long QT ventricular arrhythmia, ICD implantation was proposed, refused by the patient because he wanted to start detoxification therapy. During the hospitalization, progressive reduction of QT up to normalization in discharge. After a month new access to emergency department for presynopal episode, ECG showed sinus bradycardia with QTC 552 msec; the patient reports continuing to take excessive methadone doses and refuses treatment at a recovery center; considering that the ICD can be life-saving in this typ77e of patient (intractable addiction), we have re-proposed the ICD implant, rejected by the patient.
ANMCO POSITION PAPER: Network Organization for the Treatment of Acute Coronary Syndrome Patients during the Emergency COVID-19 Pandemic
Authors: Scotto di Uccio Fortunato , Valente Serafina , Colivicchi Furio , Murrone Adriano , Caldarola Pasquale , Di Lenarda Andrea , Roncon Loris , Amodeo Enzo , Aspromonte Nadia , Cipriani Manlio Gianni , Domenicucci Stefano , Francese Giuseppina Maura , Imazio Massimo , Urbinati Stefano , Gulizia Michele Massimo , Gabrielli Domenico 
Published: August 2020

AbstractThe COVID-19 pandemic has become a global health emergency. In Italy, the number of people infected by SARS-COVID-2 is rapidly increasing and what emerges from the current data is that the majority do not present any symptoms or only minor flu-like symptoms. In about 20% of the patients, the disease progresses towards more complex forms (interstitial pneumonia to acute respiratory distress and multiple organ failure) with the need of hospitalization in CICU and advanced ventilator assistance. The transmission of the virus occurs very easily from the symptomatic patient s droplets from coughing and sneezing and from direct contact with persons or surfaces.In a patient presenting with ST elevation (STEMI) myocardial infarction or STEMI-like, if positive to COVID-19, the reperfusion therapeutic strategy depends on the local organization and on the possibility to access without delay a PCI COVID Center, on the basis, obviously, of the risk/benefit assessment of the individual case. However, we advise to try pursuing, in the first instance, the mechanical revascularization strategy, according to the available local possibilities.
Three-dimensional gravity anomaly data inversion in the Pyrenees using compressional seismic velocity model as structural similarity constraints
Authors: Martin Roland , Giraud Jérémie , Ogarko Vitaliy , Chevrot Sébastien , Beller Stephen , Gégout Pascal , Jessell Mark 
Published: August 2020

SUMMARY
We explore here the benefits of using constraints from seismic tomography in gravity data inversion and how inverted density distributions can be improved by doing so. The methodology is applied to a real field case in which we reconstruct the density structure of the Pyrenees along a southwest–northeast transect going from the Ebro basin in Spain to the Arzacq basin in France. We recover the distribution of densities by inverting gravity anomalies under constraints coming from seismic tomography. We initiate the inversion from a prior density model obtained by scaling a pre-existing compressional seismic velocity Vp model using a Nafe–Drake relationship: the Vp model resulting from a full-waveform inversion of teleseismic data. Gravity data inversions enforce structural similarities between Vp and density by minimizing the norm of the cross-gradient between the density and Vp models. We also compare models obtained from 2.5-D and 3-D inversions. Our results demonstrate that structural constraints allow us to better recover the density contrasts close to the surface and at depth, without degrading the gravity data misfit. The final density model provides valuable information on the geological structures and on the thermal state and composition of the western region of the Pyrenean lithosphere.
Clinical summary guide: reproduction in women with previous abdominopelvic radiotherapy or total body irradiation
Authors: Rozen G , Rogers P , Chander S , Anderson R , McNally O , Umstad M , Winship A , Hutt K , Teh W T , Dobrotwir A , Hart R , Ledger W , Stern K 
Published: August 2020

AbstractSTUDY QUESTIONWhat is the evidence to guide the management of women who wish to conceive following abdominopelvic radiotherapy (AP RT) or total body irradiation (TBI)?SUMMARY ANSWERPregnancy is possible, even following higher doses of post-pubertal uterine radiation exposure; however, it is associated with adverse reproductive sequelae and pregnancies must be managed in a high-risk obstetric unit.WHAT IS KNOWN ALREADYIn addition to primary ovarian insufficiency, female survivors who are treated with AP RT and TBI are at risk of damage to the uterus. This may impact on its function and manifest as adverse reproductive sequelae.STUDY DESIGN, SIZE, DURATIONA review of the literature was carried out and a multidisciplinary working group provided expert opinion regarding assessment of the uterus and obstetric management.PARTICIPANTS/MATERIALS, SETTING, METHODSReproductive outcomes for postpubertal women with uterine radiation exposure in the form of AP RT or TBI were reviewed. This included Pubmed listed peer-reviewed publications from 1990 to 2019, and limited to English language..MAIN RESULTS AND THE ROLE OF CHANCEThe prepubertal uterus is much more vulnerable to the effects of radiation than after puberty. Almost all available information about the impact of radiation on the uterus comes from studies of radiation exposure during childhood or adolescence.An uncomplicated pregnancy is possible, even with doses as high as 54 Gy. Therefore, tumour treatment doses alone cannot at present be used to accurately predict uterine damage.LIMITATIONS, REASONS FOR CAUTIONMuch of the data cannot be readily extrapolated to adult women who have had uterine radiation and the publications concerning adult women treated with AP RT are largely limited to case reports.WIDER IMPLICATIONS OF THE FINDINGSThis analysis offers clinical guidance and assists with patient counselling. It is important to include patients who have undergone AP RT or TBI in prospective studies to provide further evidence regarding uterine function, pregnancy outcomes and correlation of imaging with clinical outcomes.STUDY FUNDING/COMPETING INTEREST(S)This study received no funding and there are no conflicts of interest.TRIAL REGISTRATION NUMBERN/A.
Geriatric Social Workers in Adult Day Care Facilities: Meditation, Worker Resilience, and Job Satisfaction
Authors: Pandya Samta P 
Published: August 2020

Abstract
This article reports a wait list control design study on the influence of an online meditation training program for geriatric social workers (GSWs) in a range of adult day care facilities across eight Asian and African cities. Results indicated that the online program was effective in building resilience and promoting job satisfaction among the intervention group. The program was more effective for participants from Asian cities, women, Hindus, and Buddhists working in transitional day care facilities and regularly logging into the self-practice sessions. Self-practice was an important mediator determining the relationship between demographic predictors and outcomes. This synchronous and asynchronous online program can be used by GSWs with some modifications for participants from African cities; men; Muslims and Christians; and those working in active adult, palliative, and memory care facilities. Refinements may entail adding familiar spiritual ideologies, some activities for men involving greater verbalization of feelings and emotions linked to the work, and intensive exercises addressing specific challenges of workers in palliative and memory care facilities.
On the Structure of Affine Flat Group Schemes Over Discrete Valuation Rings, II
Authors: Hai Phùng Hô , dos Santos João Pedro 
Published: August 2020

Abstract
In the first part of this work [ 12], we studied affine group schemes over a discrete valuation ring (DVR) by means of Neron blowups. We also showed how to apply these findings to throw light on the group schemes coming from Tannakian categories of $\mathcal{D}$-modules. In the present work, we follow up this theme. We show that a certain class of affine group schemes of “infinite type,” Neron blowups of formal subgroups, are quite typical. We also explain how these group schemes appear naturally in Tannakian categories of $\mathcal{D}$-modules. To conclude, we isolate a Tannakian property of affine group schemes, named prudence, which allows one to verify if the underlying ring of functions is a free module over the base ring. This is then successfully applied to obtain a general result on the structure of differential Galois groups over complete DVRs.
The Design of Ecological Momentary Assessment Technologies
Authors: Doherty Kevin , Balaskas Andreas , Doherty Gavin 
Published: August 2020

AbstractEcological Momentary Assessment (EMA) methods and technologies, designed to support the self-report of experience in the moment of daily life, have long been considered poised to revolutionize human-centred research, the practice of design and mental healthcare. The history of EMA is inextricably linked to technology, and mobile devices embody many of the characteristics required to support these methods. However, significant barriers to the design and adoption of these systems remain, including challenges of user engagement, reporting burden, data validity and honest disclosure. While prior research has examined the feasibility of a variety of EMA systems, few reviews have attended to their design. Through inter-disciplinary narrative literature review (n = 342), this paper presents a characterization of the EMA technology design space, drawing upon a diverse set of literatures, contexts, applications and demographic groups. This paper describes the options and strategies available to the EMA systems designer, with an eye towards supporting the design and deployment of EMA technologies for research and clinical practice.
Time-series modelling for the quantification of seasonality and forecasting antibiotic-resistant episodes: application to carbapenemase-producing Enterobacteriaceae episodes in France over 2010–20
Authors: Roux Jonathan , Nekkab Narimane , Colomb-Cotinat Mélanie , Astagneau Pascal , Crépey Pascal 
Published: August 2020

Abstract

Background
Carbapenemase-producing Enterobacteriaceae (CPE) cause resistant healthcare-associated infections that jeopardize healthcare systems and patient safety worldwide. The number of CPE episodes has been increasing in France since 2009, but the dynamics are still poorly understood.

Objectives
To use time-series modelling to describe the dynamics of CPE episodes from August 2010 to December 2016 and to forecast the evolution of CPE episodes for the 2017–20 period.

Methods
We used time series to analyse CPE episodes from August 2010 to November 2016 reported to the French national surveillance system. The impact of seasonality was quantified using seasonal-to-irregular ratios. Seven time-series models and three ensemble stacking models (average, convex and linear stacking) were assessed and compared with forecast CPE episodes during 2017–20.

Results
During 2010–16, 3559 CPE episodes were observed in France. Compared with the average yearly trend, we observed a 30% increase in the number of CPE episodes in the autumn. We noticed a 1 month lagged seasonality of non-imported episodes compared with imported episodes. Average stacking gave the best forecasts and predicted an increase during 2017–20 with a peak up to 345 CPE episodes (95% prediction interval = 124–1158, 80% prediction interval = 171–742) in September 2020.

Conclusions
The observed seasonality of CPE episodes sheds light on potential factors associated with the increased frequency of episodes, which need further investigation. Our model predicts that the number of CPE episodes will continue to rise in the coming years in France, mainly due to local dissemination, associated with bacterial carriage by patients in the community, which is becoming an immediate challenge with regard to outbreak control.
An updated phylogeny of the metallo-β-lactamases
Authors: Berglund Fanny , Johnning Anna , Larsson D G Joakim , Kristiansson Erik 
Published: August 2020

Abstract

Background
Metallo-β-lactamases (MBLs) are enzymes that use zinc-dependent hydrolysis to confer resistance to almost all available β-lactam antibiotics. They are hypothesized to originate from commensal and environmental bacteria, from where some have mobilized and transferred horizontally to pathogens. The current phylogeny of MBLs, however, is biased as it is founded largely on genes encountered in pathogenic bacteria. This incompleteness is emphasized by recent findings of environmental MBLs with new forms of zinc binding sites and atypical functional profiles.

Objectives
To expand the phylogeny of MBLs to provide a more accurate view of their evolutionary history.

Methods
We searched more than 16 terabases of genomic and metagenomic data for MBLs of the three subclasses B1, B2 and B3 using the validated fARGene method. Predicted genes, together with the previously known ones, were used to infer phylogenetic trees.

Results
We identified 2290 unique MBL genes forming 817 gene families, of which 741 were previously uncharacterized. MBLs from subclasses B1 and B3 separated into distinct monophyletic groups, in agreement with their taxonomic and functional properties. We present evidence that clinically associated MBLs were mobilized from Proteobacteria. Additionally, we identified three new variants of the zinc binding sites, indicating that the functional repertoire is broader than previously reported.

Conclusions
Based on our results, we recommend that the nomenclature of MBLs is refined into the phylogenetic groups B1.1–B1.5 and B3.1–B3.4 that more accurately describe their molecular and functional characteristics. Our results will also facilitate the annotation of novel MBLs, reflecting their taxonomic organization and evolutionary origin.