bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol And Pterostilbene Potently Inhibit SARS-CoV-2 Replication In Vitro
Authors: ter Ellen Bram M. , Kumar Nilima Dinesh , Bouma Ellen M. , Troost Berit , van de Pol Denise P.I. , van der Ende-Metselaar Heidi H. , Apperloo Leonie , van Gosliga Djoke , van den Berge Maarten , Nawijn Martijn C. , van der Voort Peter H.J. , Moser Jill , Rodenhuis-Zybert Izabela A. , Smit Jolanda M. 
Published: September 2020

AbstractThe current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. In search for therapeutic options, researchers have proposed resveratrol, a food supplement with known antiviral, anti-inflammatory and anti-oxidant properties as an advantageous antiviral therapy for SARS-CoV-2 infection. Here, we provide evidence that both resveratrol and its metabolically more stable structural analog, pterostilbene, exhibit potent antiviral properties against SARS-CoV-2in vitro. Resveratrol and pterostilbene showed antiviral activity in African green monkey kidney cells and in human primary bronchial epithelial cells cultured in an air-liquid interface system. Both compounds actively inhibit virus replication within infected cells as reduced virus progeny production was observed when the compound was added at post-inoculation conditions. Without replenishment of the compound, antiviral activity was observed up to roughly 5 rounds of replication, demonstrating the long-lasting effect of these compounds. Collectively, our data indicate that resveratrol and pterostilbene are promising antiviral compounds to treat SARS-CoV-2 infection. Because these results represent laboratory findings in cells, we advocate evaluation of these compounds in clinical trials before statements are made whether or not these drugs are advantageous for COVID-19 treatment.
ADPriboDB v2.0: An Updated Database of ADP-ribosylated Proteins
Authors: Ayyappan Vinay , Wat Ricky , Barber Calvin , Vivelo Christina A. , Gauch Kathryn , Visanpattanasin Pat , Cook Garth , Sazeides Christos , Leung Anthony K. L. 
Published: September 2020

AbstractADP-ribosylation is a protein modification responsible for biological processes such as DNA repair, RNA regulation, cell cycle, and biomolecular condensate formation. Dysregulation of ADP-ribosylation is implicated in cancer, neurodegeneration, and viral infection. We developed ADPriboDB (adpribodb.leunglab.org) to facilitate studies in uncovering insights into the mechanisms and biological significance of ADP-ribosylation. ADPriboDB 2.0 serves as a one-stop repository comprising 48,346 entries and 9,097 ADP-ribosylated proteins, of which 6,708 were newly identified since the original database release. In this updated version, we provide information regarding the sites of ADP-ribosylation in 32,946 entries. The wealth of information allows us to interrogate existing databases or newly available data. For example, we found that ADP-ribosylated substrates are significantly associated with the recently identified human protein interaction networks associated with SARS-CoV-2, which encodes a conserved protein domain called macrodomain that binds and removes ADP-ribosylation. In addition, we create a new interactive tool to visualize the local context of ADP-ribosylation, such as structural and functional features as well as other post-translational modifications (e.g., phosphorylation, methylation and ubiquitination). This information provides opportunities to explore the biology of ADP-ribosylation and generate new hypotheses for experimental testing.
Transcriptome analysis of resistant and susceptible pepper (Capsicum annuumL.) in response toXanthomonas campestrispv.Vesicatoria
Authors: Gao Shenghua , Wang Fei , Niran Juntawong , Li Ning , Yin Yanxu , Yu Chuying , Jiao Chunhai , Yao Minghua 
Published: September 2020

AbstractBacterial spot (BS) disease of pepper, incited byXanthomonas campestrispv.Vesicatoria(Xcv), is one of the most serious diseases. For a comparative analysis of defense response toXcvinfection, we performed a transcriptome analysis of BS -susceptible cultivar ECW and -resistant cultivar VI037601 using the HiSeq™ 2500 sequencing platform. Approximately 140.15 G clean data were generated from eighteen libraries. From the libraries generated, we identified 52,041 genes including 35,336 reference genes, 16,705 novel transcripts, and 4,794 differentially expressed genes (DEGs). There were 1,291, 2,956, 1,795 and 2,448 DEGs in ECW-24h-vs-ECW-0h, ECW-48h-vs-ECW-0h, VI037601-24h-vs-VI037601-0h and VI037601-48h-vs-VI037601-0h groups, respectively. Interestingly, DEGs involved in disease response in the resistant variety were induced at an earlier stage and at higher levels compared with the susceptible variety. Key enriched categories included amino sugar and nucleotide sugar metabolism, sesquiterpenoid and triterpenoid biosynthesis and MAPK signaling pathway. Moreover, 273 DEGs only differentially expressed in VI037601 and 436 overlapping DEGs in ECW and VI037601 postXcvinoculation, including NBS-LRR genes, oxidoreductase gene, WRKY and NAC transcription factors were identified, which were mainly involved in metabolic process, response to stimulus and biological regulation pathways. Quantitative RT-PCR of sixteen selected DEGs further validated the RNA-seq differential gene expression analysis. Our results will provide a valuable resource for understanding the molecular mechanisms of pepper resistance toXcvinfection and improving pepper resistance cultivars againstXcv.
Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
Authors: Bouvier Déborah , Ferrand Juliette , Chevallier Odile , Paulsen Michelle T. , Ljungman Mats , Polo Sophie E. 
Published: September 2020

ABSTRACTTranscription restart after a genotoxic challenge is a fundamental yet poorly understood process. Here, we dissect the interplay between transcription and chromatin restoration after DNA damage by focusing on the human histone chaperone complex HIRA, which is required for transcription recovery post UV. We demonstrate that HIRA is recruited to UV-damaged chromatin via the ubiquitin-dependent segregase VCP to deposit new H3.3 histones. However, this local activity of HIRA is dispensable for transcription recovery. Instead, we reveal a genome-wide function of HIRA in transcription restart that is independent of new H3.3 and not restricted to UV-damaged loci. HIRA coordinates with ASF1B to control transcription restart by two independent pathways: by stabilizing the associated subunit UBN2 and by reducing the expression of the transcription repressor ATF3. Thus, HIRA primes UV-damaged chromatin for transcription restart at least in part by relieving transcription inhibition rather than by depositing new H3.3 as an activating bookmark.
“You make me miss Pune so much”: memory making and documenting in a Virtual Zenana
Authors: Kizhakkethil Priya 
Published: September 2020

PurposeThe purpose of the study is to look at memory making and the documenting of memories, as a part of the document and information experience of women belonging to the Indian diaspora in a leisure context.Design/methodology/approachA qualitative research approach was inspired by institutional ethnography, and data are collected through semi-structured interviews and by collecting comments posted on five fan fiction blogs.FindingsEarly observations show that memory making and documenting of those memories is a part of the document experience of the research participants. It also points to the role of social interactions in that experience as well as the recording of one's document experience in the making or deriving of document meaning.Originality/valueThis study aims to contribute toward conceptual growth in the area of information and document experience. It also aims to address a gap in the literature that looks at cultural memory evocation and how it is documented, as well as looking at the interplay between affordances of new media, memory making and documentary practices especially with respect to virtual communities. And when looked at through the prism of migration and leisure, it can be even more interesting.
Systematically reviewing servant leadership
Authors: Mcquade Katie Elizabeth , Harrison Christian , Tarbert Heather 
Published: September 2020

Purpose
The purpose of this paper is to provide a comprehensive overview of the literature concerning servant leadership. The paper identifies the existing themes present within the servant leadership literature. This allows it to determine where the research concerning servant leadership lies at present and make recommendations as to further potential areas for research. It further identifies the skills necessary for servant leadership.

Design/methodology/approach
The paper follows a rigorous three-step systematic literature review (SLR) process to identify the relevant evidence to answer the research questions. The paper disseminates the results and presents them by way of a descriptive analysis. It also conducts a thematic analysis to further determine answers to the research questions.

Findings
The paper found that the most prominent themes in the servant leadership literature are values, literature reviews, behaviour, assessments, performance, characteristics and antecedents. Additionally, the paper finds that the skills necessary for servant leadership are empathy, listening, communication and trust. The review also identified gaps in the research both methodologically and empirically. It showed that more qualitative research is needed with regard to servant leadership. Furthermore, the development of empirically tested frameworks is necessary within the phenomenon.

Originality/value
Servant leadership is a phenomenon which is lacking in a reliable, validated SLR, which this paper presents. Additionally the originality of this paper lies in its recommendations for further research which are based upon the findings of a thematic analysis. As of yet, such recommendations have not yet been made within the field of servant leadership.
Unsteady stagnation-point flow and heat transfer of fractional Maxwell fluid towards a time dependent stretching plate with generalized Fourier’s law
Authors: Bai Yu , Huo Lamei , Zhang Yan 
Published: September 2020

PurposeThe purpose of this study is to investigate the unsteady stagnation-point flow and heat transfer of fractional Maxwell fluid towards a time power-law-dependent stretching plate. Based on the characteristics of pressure in the boundary layer, the momentum equation with the fractional Maxwell model is firstly formulated to analyze unsteady stagnation-point flow. Furthermore, generalized Fourier’s law is considered in the energy equation and boundary condition of convective heat transfer.Design/methodology/approachThe nonlinear fractional differential equations are solved by the newly developed finite difference scheme combined with L1-algorithm, whose convergence is verified by constructing a numerical example.FindingsSome interesting results can be revealed. The larger fractional derivative parameter of velocity promotes the flow, while the smaller fractional derivative parameter of temperature accelerates the heat transfer. The temperature boundary layer is thicker than the velocity boundary layer, and the velocity enlarges as the stagnation parameter raises. This is because when Prandtl number < 1, the capacity of heat diffusion is greater than that of momentum diffusion. It is to be observed that all the temperature profiles first enhance a little and then reduce rapidly, which indicates the thermal retardation of Maxwell fluid.Originality/valueThe unsteady stagnation-point flow model of Maxwell fluid is extended from integral derivative to fractional derivative, which has more flexibility to describe viscoelastic fluid’s complex dynamic process and provide a theoretical basis for industrial processing.
Identifying the criteria for corporate real estate decisions through the laddering technique: an analysis of care organisations in The Netherlands
Authors: Huisman Emelieke , Appel-Meulenbroek Rianne , Kort Helianthe , Arentze Theo 
Published: September 2020

PurposeBoard members and real estate managers (decision makers) play an important role in the decision-making process in nursing home organisations. This study aims to provide an understanding of underlying attributes and benefits sought by decision makers when making nursing home real estate decisions.Design/methodology/approachDecision makers from seven different nursing home organisations in The Netherlands were interviewed using the laddering technique to determine the individual requirements, the considerations of the decision alternatives, the relevant attributes and benefits and their mutual relationships.FindingsThis study details the motivations behind real estate management decisions in nursing home organisations. The findings show that apart from financial considerations, decision makers strive to enhance the quality of life and satisfaction of users with their real estate decisions and seek to include residents and employees in the process. These benefits are connected to the goals of well-being and innovation in health care. Furthermore, functionality, physical and functional flexibility and technology are key considerations when undertaking corporate real estate (CRE) decisions, to ensure that real estate management aligns with the strategic goals of the nursing home organisation.Practical implicationsThe insights of this study can support decision makers in healthcare facilities to create strategic value with their real estate. Understanding how to obtain certain benefits from nursing home real estate may result in a better realisation of organisational objectives and user needs.Originality/valueThis study reveals the decision-making process in a nursing home context. Moreover, the laddering technique is used as a new method to explore and gain a deep understanding of CRE decision-making processes.
Explaining the informal economy in Western Europe: beyond a rational economic actor perspective
Authors: Williams Colin , Oz-Yalaman Gamze 
Published: September 2020

PurposeThe dominant theorisation of the informal economy views participants as rational economic actors operating in the informal economy when the expected benefits exceed the perceived costs of being caught and punished. Recently, an alternative theory has emerged which views participants as social actors operating in the informal economy due to their lack of vertical trust (in governments) and horizontal trust (in others). The aim of this paper is to evaluate these competing theorisations.Design/methodology/approachTo do so, data are reported from special Eurobarometer surveys conducted in 2007, 2013 and 2019 in eight West European countries (Austria, Belgium, France, Germany, Ireland, Luxembourg, the Netherlands and the United Kingdom).FindingsUsing probit regression analysis, the finding is that increasing the expected likelihood of being caught and level of punishment had a weak significant impact on the likelihood of participating in the informal economy in 2007, and there was no significant impact in 2013 and 2019. However, greater vertical and horizontal trust is significantly associated with a lower level of participation in the informal economy in all three time periods.Practical implicationsThe outcome is a call for a policy to shift away from increasing the expected level of punishment and likelihood of being caught, and towards improving vertical and horizontal trust. How this can be achieved is explored.Originality/valueEvidence is provided in a Western European context to support a shift away from a rational economic actor to a social actor approach when explaining and tackling the informal economy.
When does an online brand community backfire? An empirical study
Authors: Liao Junyun , Wang Dianwen 
Published: September 2020

Purpose
Although online brand communities (OBCs) are extensively demonstrated to be an important social media tool in building brand equity, they may have backfire effects under certain conditions. Drawing from the self–brand connection theory, the purpose of this study is to investigate the effect of group heterogeneity on brand commitment. The mediation effect of self–brand connection and moderation effect of brand symbolism has also been examined.

Design/methodology/approach
Data were collected using a survey of 498 users from a range of OBCs. Hierarchical regression and bootstrapping method were used to test the research model.

Findings
The findings indicate that group heterogeneity negatively affects brand commitment in which self–brand connection plays a role of mediation. Further, the negative effect is more pronounced for high-symbolic brands than low-symbolic ones.

Practical implications
Brand managers are advised to note the dark side of OBCs in general and alleviate the adverse effects of group heterogeneity in particular, especially for high-symbolic brands.

Originality/value
Previous research pays little attention to the adverse effect of OBCs. This study enriches the literature by revealing that the backfire effect of OBCs arises when users become heterogeneous and uncovering in what situations the negative effect is stronger.
Supply chain collaboration for sustainability: a qualitative investigation of food supply chains in Brazil
Authors: do Canto Natália Rohenkohl , Bossle Marilia Bonzanini , Vieira Luciana Marques , De Barcellos Marcia Dutra 
Published: September 2020

PurposeThis paper investigates how chain members collaborate to ensure the sustainability of supply chains through the social capital perspective.Design/methodology/approachFollowing a case study design, three social capital mechanisms – reach, richness and receptivity – were used as a lens with two eco-innovative food companies and their respective supply chains in Southern Brazil. Data consisted of interviews and other sources of evidence obtained from multiple stakeholders.FindingsResults highlight the importance of a managerial orientation for sustainability and that sustainable chains presuppose a network that is closely linked and with great affinity. Not only does the management of operations improve the green performance of companies for environmental benchmarking but it also expands to include the supply chain. Social capital mechanisms can encourage partners to develop strategic initiatives for sustainability, especially if managers share key drivers for adopting eco-innovations and overall chain sustainability.Originality/valueThe paper contributes to research on collaboration within sustainable supply chain management. Empirical data were gathered from different stakeholders in two food chains in a developing country. Through the lens of social capital mechanisms, the paper shows how different types of companies collaborate in their supply chain for sustainability.
The Risk and Potentiality of Engaging with Sustainability Problems in Education—A Pragmatist Teaching Approach
Authors: Van Poeck Katrien , Östman Leif 
Published: September 2020

Abstract
This article engages in the discussion about education's role in relation to sustainability problems, a debate characterised by a tension between two legitimate concerns: a concern about the instrumentalisation of education, and a concern for the urgent need of widespread engagement and mobilisation for coping with the consequences of severe socio-ecological problems. The authors argue for an approach that takes both concerns seriously. Drawing on transactional didactic theory—underpinned by a pragmatist perspective on the interplay of continuity and change through the phases of habit, crisis and creativity—they illustrate that engagement with real-world societal problems does not inevitably result in the instrumentalisation of education. It can, on the contrary, open up a space for newness, creativity, freedom and pluralism. Yet, realising this unique educative potential does not happen automatically. It requires specific didactical work, specific forms of teaching. Through a practical example, the authors illustrate how teachers can stage problematic situations and inquiries in such a way that sustainability problems are brought to the table, turned into a common matter of concern and made free by giving the students possibilities to renew the world. Thus, they turn the question whether or not to engage with real-world problems into the question how to do so.
Rethinking Environmental Education with the Help of Indigenous Ways of Knowing and Traditional Ecological Knowledge
Authors: Nesterova Yulia 
Published: September 2020

Abstract
In recent years, Indigenous ecological knowledge has been receiving increased attention due to its potential to help address the devastating impacts of climate change and environmental degradation. Indigenous peoples in various contexts have become engaged in collaborative research projects with scientists and other experts to build environmentally sustainable societies. Environmental education has been another site for incorporation of Indigenous knowledge systems and ways of knowing. This paper presents one such programme designed by the Bunun Indigenous group in Taiwan to support environmental learning and reconnection with the natural world of their group as well as other Indigenous and non-Indigenous individuals willing to participate. While the programme's objective is learning with and from the natural environment (the lessons that can be adopted by non-Indigenous groups), its other objectives include re-building and strengthening Indigenous identities, cultures and ways of life, and potentially contributing to decolonisation of settler societies and reconciliation between groups.
Painted Bullet Holes and Broken Promises: Understanding and Challenging Municipal Dispossession in London's Public Housing ‘Decanting’
Authors: Ferreri Mara 
Published: September 2020

AbstractLow‐income municipal housing and its inhabitants have increasingly been construed as disposable within wider global dynamics of real estate speculation, leading to heightened housing insecurity, displacement and forced evictions. In Western cities urban regeneration programmes have long provided the framework for partial or wholesale demolition of public housing, drawing new frontiers of gentrification and accumulation by dispossession. Before and beyond the material loss of home, the dispossession of low‐income housing involves a deeper unmaking of the relations that constitute residents’ emplacement and political legitimacy. In this article, I present a thick ethnographic account of multiple registers of dispossession and their implications for resistance through a situated reflection on the process of ‘decanting’—as resident rehousing is colloquially known—in a South London council estate, The Heygate. Drawing on participation in an anti‐gentrification archive as a scholar‐activist, I move beyond issues of displacement and grief to analyse three key mechanisms that make becoming dispossessed possible: disowning, disavowal and the administration of differential disposability. Within a resurgent interest in municipal solutions to housing crises, there is an urgent need for understanding municipal dispossession and the role of residents and engaged scholarship in resisting and expanding imaginaries of housing justice.