bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism
Authors: Mansfield Patricia , Constantino John N. , Baldridge Dustin 
Published: April 2020

AbstractVariations in MYT1L, a gene encoding a transcription factor expressed in the brain, have been associated with autism, intellectual disability, and schizophrenia. Here we provide an updated review of published reports of neuropsychiatric correlates of loss of function and duplication of MYT1L. Of 27 duplications all were partial; 33% were associated exclusively with schizophrenia, and the chromosomal locations of schizophrenia‐associated duplications exhibited a distinct difference in pattern‐of‐location from those associated with autism and/or intellectual disability. Of 51 published heterozygous loss of function variants, all but one were associated with intellectual disability, autism, or both, and one resulted in no neuropsychiatric diagnosis. There were no reports of schizophrenia associated with loss of function variants of MYT1L (Fisher's exact p < .00001, for contrast with all reported duplications). Although the precise function of the various mutations remains unspecified, these data collectively establish the candidacy of MYT1L as a reciprocal mutation, in which schizophrenia may be engendered by partial duplications, typically involving the 3′ end of the gene, while developmental disability—notably autism—is associated with both loss of function and partial duplication. Future research on the specific effects of contrasting mutations in MYT1L may provide insight into the causal origins of autism and schizophrenia.
Enhanced removal of heavy metal ions from aqueous solution using manganese dioxide-loaded biochar: Behavior and mechanism
Authors: Zhang Haipeng , Xu Fangfang , Xue Jinyuan , Chen Shiyong , Wang Juanjuan , Yang Yanju 
Published: April 2020

AbstractIn this study, a redox precipitation method was used to load manganese dioxide (MnO2) nanoparticles on biochar (BC) (BC@MnO2) pyrolyzed from the invasive water hyacinth, and the adsorption of Cd(II),Cu(II), Zn(II), and Pb(II) was investigated. Several techniques were used to characterize the adsorbents. The results revealed that the BC surface was covered by many intertwined thin amorphous MnO2 nanosheets, which significantly increased its specific surface area and pore volume. The adsorption of heavy metal ions by BC was negligible, whereas the MnO2-containing adsorbents exhibited a high capacity for adsorbing heavy metal ions. However, the MnO2-normalized adsorption amount decreased with increasing MnO2 load and was largely unchanged at MnO2 loads of 26.6% to 30.2%. The capacity for adsorbing heavy metal ions of BC@MnO2 was pH-dependent, but the adsorption affinity was unaffected by coexisting ions. Column tests revealed that BC@MnO2 with a load of 26.6% had a high capacity for removing heavy metal ions from simulated and real electroplating wastewater. Therefore, BC@MnO2 with a load of 26.6% shows promise as a regenerable adsorbent for removing heavy metal ions from water/wastewater. This study could lay an essential foundation to develop a win-win strategy for heavy metal ions removal from wastewater using biochar derived from water hyacinth.
Reduziert die Anwendung der Kryotherapie den erlebten Schmerz bei der Shuntpunktion nativer AV-Fisteln?
Authors: Sperling Rebecca 
Published: April 2020

ZUSAMMENFASSUNGDie Auseinandersetzung mit dem Thema Schmerz ist für eine nephrologische Pflegefachkraft unvermeidlich. Ziel dieser Arbeit ist es, herauszufinden, ob die Anwendung der lokalen Kryotherapie vor der Shuntpunktion den erlebten Punktionsschmerz einer nativen AV-Fistel reduzieren kann. Da mehrere Studien und Arbeiten bereits einen schmerzlindernden Effekt der Kryotherapie feststellten, zielte die Untersuchung darauf ab, diesen Effekt auch zur Schmerzreduktion bei der Shuntpunktion zu nutzen. Die Untersuchung wurde in einer Vorher-Nachher-Studie an 6 Hämodialysepatienten durchgeführt. Die Ermittlung der individuellen Schmerzwerte erfolgte anonym über die numerische Rating-Skala (NRS; 0–10). In den ersten 2 Wochen erfolgten die Messungen ohne Intervention, anschließend folgten 2 Wochen mit 5-minütiger Anwendung der lokalen Kryotherapie. Die Auswertung der Ergebnisse zeigte, dass es zu einer Reduktion des empfundenen Schmerzes bei der Anwendung von lokaler Kryotherapie kommt. Aus der vorliegenden Arbeit leitet sich die Wichtigkeit eines adäquaten Punktionsschmerzmanagements für Dialysepatienten ab. In der heutigen Zeit, in der immer größere medizinische Fortschritte gemacht werden, sollte der Umgang mit den „einfachen“ Methoden wie der Kälteanwendung nicht in Vergessenheit geraten.
Der Querulantenwahn in der 1. Hälfte des 20. Jahrhunderts: Der Fall Elsa Asenijeff (1867–1941) und die deutschsprachige psychiatrische Literatur der Zeit
Authors: Kommol Philipp , Steinberg Holger 
Published: April 2020

Zusammenfassung
Anliegen Die Schriftstellerin Elsa Asenijeff wurde 1921 unter der Diagnose Querulantenwahn entmündigt. An diesen Fall soll erinnert und hinterfragt werden, was unter dem Krankheitsbild zu dieser Zeit verstanden wurde. Damit wird ein Beitrag zur Konzeptgeschichte dieser wenig historisch aufgearbeiteten wahnhaften Störung geleistet.
Methode Das Wesentliche der ärztlichen Gutachten über Elsa Asenijeff sowie der Konzepte zum Querulantenwahn in psychiatrischen Lehrbüchern des beginnenden 20. Jahrhunderts wird dargestellt.
Ergebnisse Es wird eine wahnhafte Störung beschrieben, deren Auslöser ein juristischer Streitfall war. Die Lehrbuchautoren unterscheiden sich in ihren Theorien zur Genese und Klassifikation.
Schlussfolgerungen Die in den Gutachten geschilderte Symptomatik stimmt im Kern mit der Lehrmeinung der Zeit überein. Gleichzeitig wird die Schwierigkeit einer klaren Differenzierung zwischen Gesundheit und Krankheit deutlich.
Determining the next step: how organizations and aging employees determine whether to stay or to go
Authors: Wilson Tom 
Published: April 2020

Purpose
This paper aims to discuss the guiding principles for how to find solutions to a complex problem facing HR professionals: What to do with those who could or should retire and move on to the next stage of their lives?

Design/methodology/approach
The author offers five guiding principles that may help you find a solution suited to your organization. These principles should help you assess where to focus your efforts and how to build a plan for moving forward. He then provides several potential solutions for HR professionals and their aging workforce to consider.

Findings
The challenge to the human resource professional and the organization’s executives is to understand these guiding principles and develop solutions that work for the organization, business conditions and people.

Originality/value
With these guiding questions and considerations in mind, HR professionals can better help their aging workforce stay, go or find a solution in between.
Correlation between clinical risk factors and tracheal intubation difficulty in infants with Pierre-Robin syndrome: a retrospective study
Authors: Liu Yanli , Wang Jiashuo , Zhong Shan 
Published: April 2020

Abstract
Background
Difficult tracheal intubation is a common problem encountered by anesthesiologists in the clinic. This study was conducted to assess the difficulty of tracheal intubation in infants with Pierre Robin syndrome (PRS) by incorporating computed tomography (CT) to guide airway management for anesthesia.

Methods
In this retrospective study, we analyzed case-level clinical data and CT images of 96 infants with PRS. First, a clinically experienced physician labeled CT images, after which the color space conversion, binarization, contour acquisition, and area calculation processing were performed on the annotated files. Finally, the correlation coefficient between the seven clinical factors and tracheal intubation difficulty, as well as the differences in each risk factor under tracheal intubation difficulty were calculated.

Results
The absolute value of the correlation coefficient between the throat area and tracheal intubation difficulty was 0.54; the observed difference was statistically significant. Body surface area, weight, and gender also showed significant difference under tracheal intubation difficulty.

Conclusions
There is a significant correlation between throat area and tracheal intubation difficulty in infants with PRS. Body surface area, weight and gender may have an impact on tracheal intubation difficulty in infants with PRS.
Methodology for Estimation and Calculation of the Level of Development of Urban Agglomerations (on Materials of Barnaul Agglomeration)
Authors: Garnov Andrey , Himochka V. , Goloschapova I. , Robec D. 
Published: April 2020

Purpose: Development of a methodology for assessing the development of urban agglomerations and calculating the level of their development.
Discussion: The article presents the theoretical, methodological and practical aspects of the diagnosis of the regional economic area, explores the existing methodological and methodological approaches to assess the development of urban agglomerations. The development of the territory is assessed by indicators of the population settlement system and transport accessibility of the satellite zone to the core of the agglomeration. But since the object of our study is agglomeration formed in a territory with a diverse economic structure and a complex spatial and demographic characteristic, the above set of indicators for assessing the level of development is not enough.
Results: A technique is proposed that determines the sequence of actions in the formation of urban agglomerations. The level of development of the urban agglomeration is analyzed. Indicators are proposed for assessing the level of agglomeration development, which were applied on the materials of the Barnaul agglomeration. In the subregion we are considering, the urbanized type of territorial and economic structure dominates. However, the inclusion of rural municipalities in the agglomeration changes the type of urban agglomeration to industrial-agriculture agglomeration.
Activity of Vip3Aa1 against Periplaneta americana
Authors: Liu Wenbin , Wu Lirong , Wang Jie , Li Xiaobo , Jin Xiaobao , Zhu Jiayong 
Published: April 2020

AbstractBacillus thuringiensis(Bt) is a well-known entomopathogen. In this study, we cloned thevip3Aa1gene fromBtstrain GIM1.147 and investigated the insecticidal activity ofBtVip3Aa1 protein produced byEscherichia coliagainstPeriplaneta americanaandBlattella germanica. The results showed that purified Vip3Aa1 exhibited an LC50at 24 h againstP. americanaandB. germanicaof 0.182 mg·ml-1and 0.276 mg·ml-1, respectively. Investigations of its mode of action showed that Vip3Aa1 could be proteolyzed into a 62-kDa toxic protein byP. americanagut-soluble proteases. In addition, Vip3Aa1 caused severe damage to the columnar colon and the midgut, as observed through hematoxylin-eosin staining and scanning electron microscopy. The 62-kDa activated Vip3Aa1 protein could form ion channels in the colon and the midgut in vitro. Based on protease activity analysis, Vip3Aa1 at concentrations of 0.125 mg·ml-1and 0.031 mg·ml-1could downregulate the activities of glutathione S-transferase, α-NA esterase, trypsin, and chymotrypsin. This report provides the first description of the activity of Vip3Aa1 toxins towardP. americanaandB. germanicaand demonstrates that the mechanism through which Vip3Aa1 killsP. americanaandB. germanicadiffers from that involved in the killing of lepidopteran insects.
Molecular detection and evaluation of resistance of Mycoplasma Pneumoniae to macrolide (Erythromycin) due to mutation in the 23S rRNA gene among Iranian Patients with respiratory infections
Authors: Niakan Mohammad , Rostampur Susan , Mirnejad Reza , Halaji Mehrdad , Pouladi Iman 
Published: April 2020

Abstract
Objective: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. The global increased resistance of M. pneumoniae strains to macrolide (ML) has become a worrisome health problem. The widespread use of these drugs has led to increased rate of reported ML-resistant M. pneumoniae (MRMP) throughout the world. Therefore, this study was aimed to evaluate the resistance of M. pneumoniae against erythromycin due to mutations in the 23S rRNA gene of patients with respiratory infections in Iran.Results: According to the findings of the present study, employing specific primers showed that 17 cases (17%) were positive for mycoplasma genus and 6 cases (6%) positive for M. pneumoniae species. Also, analysis of the sequence of 23S rRNA gene, revealed that one of the samples had mutations at positions A2431G and G2491A. Measuring the minimum inhibitory concentration (MIC), revealed that all samples positive for M. pneumoniae with 23S rRNA gene were sensitive to erythromycin, and no ML resistance was reported.
Harmonizing Formula Prescription Patterns for Chronic Kidney Disease: A Population-Based Cross-Sectional Study
Authors: Lin Hung-Lung , Lin Ming-Yen , Tasi Cheng-Hsun , Wang Yi-Hsiu , Chen Chung-Jen , Hwang Shang-Jyh , Chiu Yi-Wen 
Published: April 2020

Abstract
Background Harmonizing formulas have been demonstrated to be associated with reduced risk of end-stage renal disease in patients with chronic kidney disease (CKD). However, the target population and indications of harmonizing formulas in CKD remain unknown. Methods We conducted a population-based cross-sectional study to explore factors associated with harmonizing formulas prescription. Patients who had been prescribed harmonizing formulas after CKD diagnosis were defined as the using harmonizing formulas group. Disease diagnoses for harmonizing formula prescriptions and patient characteristics related to the prescriptions were collected. Results In total, 24,971 patients were enrolled in this analysis, and 5,237 (21%) patients were prescribed harmonizing formulas after CKD diagnosis. The three most frequent systematic diseases and related health problems for which harmonizing formula prescriptions were issued in CKD were symptoms, signs, and ill-defined conditions (24.5%), diseases of the digestive system, (20.67%), and diseases of the musculoskeletal system (12.9%). Higher likelihoods of harmonizing formula prescriptions were associated with young age (adjusted odds ratio: 0.98, 95% confidence interval: 0.97–0.98), female sex (1.79, 1.68–1.91), no diabetes (1.20, 1.06–1.35), no hypertension (1.38, 1.26–1.50), no cerebrovascular disease (1.34, 1.14–1.56), less disease severity (0.86, 0.83–0.89), using nonsteroidal anti-inflammatory drugs (NSAIDs) (1.65, 1.54–1.78), and using analgesic drugs other than NSAIDs (1.46, 1.35–1.59). Conclusions Harmonizing formulas are commonly used for treating symptoms of the digestive and musculoskeletal systems in CKD cases. Further research on harmonizing formula effectiveness with regard to particular characteristics of CKD patients is warranted.
Diabetes in Patients with Ataxia telangiectasia: A National Cohort Study
Authors: Donath Helena , Hess Ursula , Kieslich Matthias , Theis Marius , Ohlenschläger Ute , Schubert Ralf , Wölke Sandra , Zielen Stefan 
Published: April 2020

Abstract
Background: Ataxia telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder characterized by pronounced cerebellar ataxia, telangiectasia, cancer predisposition and altered body composition. In addition, evidence is rising for endocrine dysfunction. Objectives: To determine the evolution of diabetes and its prevalence in a larger A-T cohort. Methods: A retrospective analysis of the patient charts of 39 subjects from the Frankfurt A-T cohort was performed between August 2002 and 2018 concerning HbA1c and oral glucose tolerance (OGTT). The median follow-up period was 4 years (1-16 years). In addition, in 31 A-T patients aged 1 to 38 years HbA1c and fasting glucose were studied prospectively from 2018-2019. Results: In the retrospective analysis, we could demonstrate a longitudinal increase of HbA1c. The prospective analysis showed a significant increase of HbA1c and fasting glucose with age (r = 0.79, p <0.0001). OGTT has a good sensitivity for IR screening, whereas HbA1c can be used to evaluate individual courses and therapy response. Seven out of 39 (17.9%) patients suffered from diabetes. Metformin did not always lead to sufficient diabetes control; one patient was treated successfully with repaglinide. Conclusion: Diabetes is a common finding in older A-T patients and often starts in puberty. Our data clearly demonstrate the need for an annual diabetes screening in patients > 12 years.
Risk factors for Accidental Foreign Body Aspiration and Ingestion in Dental Practice: A Seven-Year Retrospective Study
Authors: Huh Jisun , Kim Ki-Yeol , Jung Seoyeon , Cha Jungyul , Kim Kee-Deog , Park Wonse 
Published: April 2020

Abstract
Objective: This retrospective study investigated the incidence rate of accidental foreign body aspiration and ingestion according to patient sex and age and the dental department. This study was aimed to verify the risk factors for accidental foreign body aspiration and ingestion in dental practice. Methods: Accidental foreign body aspiration and ingestion cases were collected by searching the electronic health records and the Safety Report System of Yonsei University Dental Hospital from January 2011 to December 2017. The collected data comprised the patient age, sex, and medical condition, treatment procedure, and foreign objects that were accidentally aspirated or ingested. The incidence rate was calculated as the number of accidental foreign body aspirations and ingestions relative to the total number of patient visits, and differences according to the patient sex and age and the dental department were identified statistically. Results: There were 2 aspiration and 37 ingestion cases during the 7-year analysis period. The male-to-female incidence ratio was 22.7:8.1. The incidence rate trended upward with age and increased rapidly among those aged 80 or older. Seven of the 39 patients had intellectual disability, Lou Gehrig’s disease, dystonia, or oral and maxillofacial cancer. The incidence rate was the highest in the Predoctoral Student Clinic and the Department of Prosthodontics. The most frequently swallowed objects were fixed dental prostheses and dental implant components. Conclusion: The incidence rate of accidental foreign body aspiration and ingestion is higher in men than in women and the highest in patients aged 80 or older. The most frequently aspirated or ingested objects are fixed dental prostheses and dental implant components. Dental practitioners need to identify high-risk patients and apply various methods to prevent accidental foreign body aspiration and ingestion in dental clinics. Inexperienced dentists should be especially careful. Keywords: accidental foreign body aspiration and ingestion, incidence rate, dental treatment
La obra de H.-G. Gadamer
Authors: De Santiago Guervós Luis E. 
Published: April 2020

RESUMENInforme bibliográfico actualizado de las obras de Hans-Georg Gadamer. Incluye sus obras en alemán desde 1922 hasta 1997 y las traducciones al español hasta 1997. Se añade un pequeño repertorio sobre fuentes bibliográficas. PALABRAS CLAVEGADAMER-HERMENEUTICA.FILOSOFIA CONTEMPORANEAABSTRACTBibliographical report on the work of Hans-georg Gadamer. it covers his German works as from 1922 to 1997, as well as the Spanish translations until 1997. A small list of "bibliographical Sources" is also enclosedKEYWORDSGADAMER-HERMENEUTICS-CONTEMPORARY PHILOSOPHY
Pengaruh Pengetahuan Peraturan Perpajakan Dan Kualitas Pelayanan Terhadap Kepatuhan Wajib Pajak Pada Kantor Pelayanan Pajak Pratama Bandung Karees
Authors: Saputri Dwi Anggraeni , Sulistia Ela 
Published: April 2020

Kepatuhan wajib pajak salah satunya dapat dilihat dari jumlah wajib pajak dalam menyampaikan Surat Pemberitahuan (SPT), beberapa faktor yang mempengaruhi kepatuhan wajib pajak yaitu pengetahuan peraturan perpajakan yang dimiliki oleh wajib pajak serta kualitas pelayanan yang diberikan oleh aparat pajak. Tujuan dilakukannya penelitian ini adalah untuk mengetahui seberapa besar pengaruh pengetahuan peraturan perpajakan dan kualitas pelayanan terhadap kepatuhan wajib pajak baik secara parsial maupun secara simultan.Penelitian ini merupakan penelitian deskriptif verifikatif bersifat kausalitas. Penelitian ini dilakukan di KPP Pratama Bandung Karees. Teknik sampel dilakukan adalah conveniance sampling dengan total sampel terdiri dari 100 orang wajib pajak orang pribadi, 22 orang dari Account Representative (AR), dan 11 orang dari pemeriksa pajak. Pengujian statistik yang digunakan adalah perhitungan korelasi pearson, uji asumsi klasik, koefisien determinasi, analisis regresi berganda, uji hipotesis dengan menggunakan aplikasi SPSS 17,0.Hasil dari penelitian ini menunjukkan bahwa pengetahuan peraturan perpajakan dan kualitas pelayanan secara simultan berpengaruh signifikan terhadap kepatuhan wajib pajak dengan tingkat koefisien determinasi 19,3%. Secara parsial pengetahuan peraturan perpajakan berpengaruh signifikan dengan arah negatif, sedangkan kualitas pelayanan tidak berpengaruh signifikan dengan arah negatif terhadap kepatuhan wajib pajak.
Kata kunci: Pengetahuan Peraturan Perpajakan, Kualitas Pelayanan, Kepatuhan Wajib Pajak.
Nueva alternativa para el tratamiento para Covid 19 en Ecuador
Authors: Ojeda Crespo Alexander Oswaldo , Ojeda Cedillo Alexander Javier , Ojeda Cedillo Peter Oswaldo , Ojeda Cedillo Andres Eduardo , León Anaximenes 
Published: April 2020

En Ecuador hay más de 4000 casos confirmados de coronavirus, y Guayaquil reporta el mayor número de contagiados y 450 muertos en todo el país. Y según los expertos médicos estiman que los fallecidos en los siguientes meses llegarán a entre 2500 y 3500 por covid 19 solo en la provincia del Guayas. La epidemia comenzó en Wuhan, China, y se extendió rápidamente por todo el país y posteriormente en todo el mundo. La OMS advierte que COVID-19 es el "enemigo público número 1" y potencialmente más poderoso que el terrorismo por lo que declaro la pandemia. El objetivo de la presente investigación es determinar el beneficio de la utilización por vía oral de claritomicina,viusid,N-acetilcisteina y Te caliente. Material y métodos: Los pacientes fueron cuatro médicos, dos enfermeras y seis pacientes particulares en edades comprendidas entre 35 a 65 años de edad y todos residentes en Machala-Ecuador. Los seis primeros por contagio hospitalario y los seis restantes por contagio comunitario. Se administró claritromicina 500mg cada 12 horas, N-acetilcisteina 600mg, Viusid tres sobres diarios y Té caliente cuatro veces en los pacientes contagiados con COVID 19 y la mitad de la dosis en los contactos. Existen tratamientos utilizados en varios países del mundo con diferentes resultados, y, ante la situación gravísima del Ecuador, comparto mi experiencia personal con benéficos excelentes y evolución favorable de los pacientes.
Palabras claves
COVID-1, Coronavirus, pandemia, tratamiento