bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hedonic Price Functions and Wine Price Determinants: A Review of Empirical Research
Authors: Outreville Jean-François , Le Fur Eric 
Published: January 2020

Abstract
The objective of this paper is to present a descriptive review of all the studies published on wine price determinants. The selection process has been carefully designed to assure that we cover the complete literature of hedonic price functions and wine price determinants. Because of the heterogeneity among these studies, the objective was to classify all the determinants in clusters related to geographical and agricultural factors, time horizon, public information and, supply factors (production costs and volume of production).
For this review, we have identified a list of 117 papers published on price determinants over the period 1993 to 2018.
In vitro equivalence of generic and branded amoxicillin tablet by microbiological assay method
Authors: Avianto Primadi , Mahfudz  , Suharjono  , Isnaeni  , Alderman Christopher Paul 
Published: January 2020

Abstract

Background
Indonesian Ministry of Health advocate doctors, especially in government-owned healthcare facility, to prescribe generic drugs including amoxicillin. Although BPOM (the National Agency of Drug and Food Control) already guarantees that the generic amoxicillin and the branded one were interchangeable, lack of confidence in generic drugs still remains among patients, pharmacists, and doctors. This issue supported by lack of publication confirmed the therapeutic equivalence of branded and generic drugs. This study aims to evaluate and compare the in vitro microbiological assay of different generic and branded amoxicillin that are available in Indonesian market, especially those used in government-owned healthcare facilities.

Methods
Microbiological assays for five samples of amoxicillin tablet containing 500 mg amoxicillin available in Indonesia were determined using a method from Indonesia Pharmacopeia. Samples were coded as Products A to E. The assay was carried out by measuring the diameter of the inhibition zones in the plate agar incubated with Escherichia coli and Staphylococcus aureus. The obtained data were evaluated to determine the sample potency and compared with the amoxicillin reference standard.

Results
Minor and insignificant differences (p > 0.05) were found in the diameters of the inhibition zones. Potency ratio measured both in E. coli and S. aureus were all between 95% and 105%. The lowest of the tested samples were from Product C, which resulted to ratio potencies of 96.3% and 95.5% in E. coli and S. aureus, respectively.

Conclusions
All five samples were in the range of the acceptance criteria. Therefore, from the view of the microbiological assay, these products are in equivalence in quality and are interchangeable.
Cinacalcet treatment experience in hereditary vitamin D resistant rickets
Authors: Lucas Jesús , Badia Jose Luis , Lucas Elena , Remon Ana 
Published: January 2020

Abstract

Background
Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR). Mutations in the DNA-binding domain of the VDR of the vitamin D receptor have been characterized by a lack of response to traditional treatment with calcium and calcitriol. Secondary hyperparathyroidism and hypophosphatemia are the main factors in its pathogenesis. Cinacalcet is a calciomimetic drug that reproduces the action of calcium by increasing the sensitivity of the calcium-sensitive receptors (CASR) of the parathyroid glands that regulate the secretion of the parathyroid hormone (PTH).

Case presentation
We describe its effectiveness and safety in a patient with HVDRR and review other published report cases in the literature. According to published experience, cinacalcet could be used as an adjunctive treatment for the HVDRR with mutations in the DNA-binding domain of the VDR refractory to traditional treatment. Due to lack of knowledge of possible effects of cinacalcet on CASR in the skeleton, long-term use should be avoided.

Conclusions
The optimal dose of cinacalcet for treatment of HVDRR ranges between 0.25 and 0.5 mg/kg/day. Serious side effects of cinacalcet have not been published in this type of patient, although we considered that a close monitoring is necessary in order to detect hypocalcemia.
Predictors of non-alcoholic fatty liver disease (NAFLD) among children with obesity
Authors: Mohamed Rashdan Zaki , Jalaludin Muhammad Yazid , Anuar Zaini Azriyanti 
Published: January 2020

Abstract

Background
The prevalence of childhood obesity and its related comorbidities in Malaysia are alarming. Malaysia ranked second in childhood obesity among South-east Asian countries with a prevalence of 12.7%. This study was conducted to investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) among obese children and to ascertain the predictors associated with NAFLD.

Methods
NAFLD was diagnosed via ultrasonographic evidence of fatty liver in obese and overweight children who presented to the Paediatric Obesity Clinic of University Malaya Medical Centre (UMMC), Malaysia. Demographic, anthropometric, clinical and biochemical parameters were analysed and compared between the NAFLD and non-NAFLD groups. Statistical analyses were carried out.

Results
Twenty-one out of 33 obese and overweight children (63.6%) were found to have NAFLD. We found that 62% of our study population in the NAFLD group had metabolic syndrome based on the definition by the International Diabetes Federation (IDF). Mean body mass index (BMI), waist circumference (WC), triglyceride (TG) and alanine aminotransferase (ALT) were found to be significantly greater in the NAFLD group compared to the non-NAFLD group (35.2 [6.1] vs. 29.3 [4.7] kg/m2 [p-value 0.007]; 104.1 [11.4] vs. 94.1 [12] cm [p-value 0.034]; 1.5 [0.9] vs. 0.9 [0.3] mmol/L [p-value 0.002]; 60.7 [53.8] vs. 27.3 [13] U/L [p-value 0.007]). Multivariate regression analysis revealed TG as the independent predictor for NAFLD, with an odds ratio of 41.7 (95% confidence interval [CI] 0.001, 0.819) (p-value 0.04).

Conclusions
Prevalence of NAFLD among children who are obese and overweight is alarming with 62% having metabolic syndrome. TG was found to be a strong predictor for NAFLD.
Variations in long-term outcome reporting among offspring followed up after lifestyle interventions in pregnancy: a systematic review
Authors: Olmedo-Requena Rocío , Amezcua-Prieto Carmen , Al Wattar Bassel H. , Rogozinska Ewelina , Bueno-Cavanillas Aurora , Juan Jiménez-Moleón José , Thangaratinam Shakila , Khan Khalid S. 
Published: January 2020

Abstract

Background
Mothers and their offspring may benefit from lifestyle interventions during pregnancy. We systematically reviewed the literature to map and evaluate the quality of long-term offspring outcomes in follow-up cohorts of randomised controlled trials (RCTs).

Methods
We searched MEDLINE, EMBASE, CINAHL, Database of Abstracts of Reviews of Effects and Cochrane Central (until March 2019) for all RCTs evaluating any lifestyle (diet or exercise) intervention during pregnancy and their follow-up cohorts. Two reviews evaluated the extracted outcomes using two standardised assessment tools, one for quality of reporting (score range 0–6) and another for the variation in outcome selection. We extracted data in duplicate and reported using natural frequencies, medians, ranges, means and standard deviation (SD).

Results
We captured 30 long-term offspring outcomes reported in six articles (four studies). Offspring anthropometric measurements were the most commonly reported outcomes. There was a large variation in the measurement tools used. The mean overall quality score for outcome reporting was 3.33 (SD 1.24), with poor reporting of secondary outcomes and limited justification for the choice of the reported outcomes. Most studies showed selective reporting for both their primary and secondary outcomes.

Conclusion
The quality of reporting for long-term offspring outcomes following lifestyle interventions in pregnancy is varied with evidence of selective outcome reporting. Developing a core outcome set will help to reduce the variations in outcome reporting to optimise future research.
An overview on the concentration of radioactive elements and physiochemical analysis of soil and water in Iraq
Authors: Alam Iftikhar , Rehman Jalil ur , Ahmad Nisar , Nazir Alia , Hameed Aslam , Hussain Altaf 
Published: January 2020

AbstractIn the last decade, radiation physics brought about a revolution in health science by improving scientific equipment and useful methodologies for measurement. Human beings are affected by ionizing radiations that radiate from radioactive elements. The quantity of radioactive elements is different inside and outside the earth’s surface. Soil and water are exigencies of human lives which are contaminated by radioactive elements. These radioactive elements enter into the human body through drinking, eating and breathing. On reaching hazardous limits in the human body, these radioactive elements cause stomach cancer, lung cancer and leukemia. Measurement of radioactive elements in soil and water is helpful in monitoring the health issues caused by exposure to these elements. In Iraq, numerous studies about natural radioactivity, radon concentration and physiochemical parameters have been conducted by different researchers, of which most of the studies were conducted in Barsa, Nasirya, Najaf, Karbala, Baghdad, Balad, Kirkuk, Erbil, Mosul and Dohuk cities. This article aims to review and compile the studies conducted in these cities of Iraq from 2011 to 2019. In most articles, high-purity germanium (HPGe), RAD7 and CR-39 detectors are used for radioactivity and radon measurement. These cities are located in the low-high folded and Mesopotamian zones. From this study, it can be concluded that radon concentration in soil and water was greater in the Mesopotamian and lower in the low-high folded zones. Higher concentrations of natural radioactivity in water and soil were found in the low-high folded zone in Iraq. However, most of the conducted studies show that concentrations of radon and natural radioactivity are above the permissible limits recommended by the International Commission on Radiological Protection (ICRP) and World Health Organization (WHO). The values of physiochemical parameters were found to be greater in the Mesopotamian zone, but overall they are not above the permissible limits.
Assessment of the efficacy of passive cellular immunotherapy for glioma patients
Authors: Cao Jun-Xia , Gao Wei-Jian , You Jia , Wu Li-Hua , Wang Zheng-Xu 
Published: January 2020

Abstract
To evaluate the therapeutic efficacy of passive cellular immunotherapy for glioma, a total of 979 patients were assigned to the meta-analysis. PubMed and the Cochrane Central Register of Controlled Trials were searched initially from February 2018 and updated in April 2019. The overall survival (OS) rates and Karnofsky performance status (KPS) values of patients who underwent passive cellular immunotherapy were compared to those of patients who did not undergo immunotherapy. The proportion of survival rates was also evaluated in one group of clinical trials. Pooled analysis was performed with random- or fixed-effects models. Clinical trials of lymphokine-activated killer cells, cytotoxic T lymphocytes, autologous tumor-specific T lymphocytes, chimeric antigen receptor T cells, cytokine-induced killer cells, cytomegalovirus-specific T cells, and natural killer cell therapies were selected. Results showed that treatment of glioma with passive cellular immunotherapy was associated with a significantly improved 0.5-year OS (p = 0.003) as well as improved 1-, 1.5-, and 3-year OS (p ≤ 0.05). A meta-analysis of 206 patients in one group of clinical trials with 12-month follow-up showed that the overall pooled survival rate was 37.9% (p = 0.003). Analysis of KPS values demonstrated favorable results for the immunotherapy arm (p < 0.001). Thus, the present meta-analysis showed that passive cellular immunotherapy prolongs survival and improves quality of life for glioma patients, suggesting that it has some clinical benefits.
Germaine de Staël’s Réflexions sur le procès de la reine: An act of compassion?
Authors: Cabak Rédei Anna 
Published: January 2020

Abstract
In the foreword to the Mercure de France edition of de Staël. (1996 [1793]. Réflexions sur le procès de la reine. Paris: Mercure de France), Chantal Thomas, French historian and writer, writes that this apology in favor of Marie-Antoinette did not help the queen nor the author herself; on the contrary it only made the latter more unpopular. So why did Germaine de Staël write it? Mme de Staël and Marie-Antoinette did not share many interests; however, at the moment of The Women’s March on Versailles in October 1789, the situation had changed. It was at this moment, when Mme de Staël witnessed people’s hatred for the Queen, that she for the first time felt that she was on her side. She had the feeling that the Queen would be a victim to a public opinion that had been “manipulated” (Thomas. 1996. Preface. In Réflexions sur le procès de la reine, 7–14. Paris: Mercure de France: 12) in a systematic way, and to which she herself had been a victim. Pursuing some ideas formulated by Reddy (2000, 2001) and (Nussbaum, Martha C. 2001. Upheavals of thought: The intelligence of emotions. Cambridge: Cambridge University Press.) in their work on emotion and empathy in history and philosophy respectively, I hope to offer some suggestions, with the aid of cultural semiotics. More specifically I hope to be able to provide some answers to the question whether Mme de Staël’s apology might be regarded as an act of compassion.
Early body ornamentation as Ego-culture: Tracing the co-evolution of aesthetic ideals and cultural identity
Authors: Iliopoulos Antonis 
Published: January 2020

AbstractWhile the “symbolic” meaning of early body ornamentation has received the lion’s share of attention in the debate on human origins, this paper sets out to explore their aesthetic and agentive dimensions, for the purpose of explaining how various ornamental forms would have led interacting groups to form a cultural identity of their own. To this end, semiotics is integrated with a new paradigm in the archaeology of mind, known as the theory of material engagement. Bridging specifically Peirce’s pragmatic theory and Malafouris’ enactive take on aesthetics allows us to appreciate the formation of aesthetic ideals through the agentive effects of material signs. It is thus proposed that, by attending to the interrelation between form, effect, and affect, members of social groups would have come to appreciate the ways in which their ornamental culture resembles and differs from that of neighbouring groups. Following the Lund conception of cultural semiotics, I argue that models of Ego-culture would have come to evolve along Alter-cultures that also employ ornaments, and against Alius-cultures that have yet to develop or adopt personal decoration. The aesthetic ideals associated with early body ornaments must have therefore played a catalytic role in the formation and communication of group membership. I thus close by proposing that the origins of new cultural identities can be explained by tracing the co-development of ideas and ideals.
Careless crime: state, dynamics, measures of general and special counteraction
Authors: Avdeev Vadim A. , Avdeeva Olga A. 
Published: January 2020

The subject of the study is careless crime, taking into account the implemented national criminal law policy. The aim of the study is to investigate the scientific understanding, content and types of careless crime. Attention is focused on the state, dynamics of careless crime, measures of General and special counteraction to the specified social and legal phenomenon. The methodological basis of counteraction measures is formed by a set of General scientific and private scientific methods, which allowed to investigate the process of novelization of criminal legislation and its implementation at the law enforcement level.
The main results of the study reflect the problems of prevention, prevention, General and special counteraction to careless crime, affecting the effectiveness of the implementation of the mechanism of criminal law regulation of social relations associated with crimes committed by carelessness or negligence. Conclusions concerning types of careless crime, its specific weight, the personality of the careless criminal, including scientific substantiation of the General and special counteraction measures are formulated.
The scientific and practical validity of legislative processes is noted as the defining problem. The problems of implementation of the criminal law in the context of increasing rates of careless crime, actualizing the practice-oriented measures of counteraction, based on the state, structure, dynamics of the development of this social and legal phenomenon. Attention is focused on strengthening the sanctions of criminal law norms regulating increased responsibility for certain types of careless crimes, which in fact do not affect the reduction of criminal tension in the sphere of careless crime. The problematic issues of improving the quality of the criminal law and other normative legal acts providing prevention, prevention and counteraction to careless crimes are revealed. The focus is on improving the quality of activities of state authorities, self-government bodies and civil society institutions, increasing the level of control.
TÜKETİCİLERIN GELİŞİME AÇIKLIK KİŞİLİK ÖZELLİĞİ İLE ONLINE ALIŞVERIŞLERDEKİ KARAR VERME TARZLARI ARASINDAKİ İLİŞKİ
Authors: Bilginer Fatma gül , Saltan Onur Fatih 
Published: January 2020

Gün geçtikçe türlü online işlerle vakit
geçiren bireylerin sayısı artmaktadır.Birçok ürün ve hizmete ilişkin internet
üzerinden satın alım kararının verilmesi günümüzün önemli tüketim tarzları
arasında yer almaktadır. Bundan dolayı, pazarlama biliminin en önemli araştırma konuları arasında online
tüketici davranışı da yer almıştır.Ancak online ortamın kendine has bazı
özellikler taşıması, tüketicinin bu ortamda karar verme tarzına da yeni bakış
açıları kazandırmıştır. Bu araştırmanın amacı, tüketicilerin gelişime açıklık
kişilik özelliği göz önünde bulundurarak, online alışveriş ortamında karar
verme tarzları arasındaki ilişkiye yönelik uygulamalı bir araştırma
gerçekleştirilmiştir. Kilis ilinde yaşayan 330 kişi araştırmanın örneklemini
oluşturmuş olup veri toplama aracı olarak anketten faydalanılmıştır.Analiz
kapsamında değişkenler arasında belirli kolerasyon ve regresyon analizleri
yapılmış olup elde edilen sonuçlara göre
tüketicilerin online karar verme tarzlarının her boyutunda gelişime açıklık
ölçeğinin yeniliklere açıklık boyutuyla ilişki olduğu ve buradan yola çıkarak
yeniliğe açık kişilerin online karar verme tarzları arasında pozitif ve anlamlı
bir ilişki olduğu söylenebilir. Bunun yanında kültürel gelişime açık
tüketicilerin sadece web sitesi içeriği ve ara yüze duyarlılık boyutları
ile arasında pozitif ve anlamlı ilişki
olduğu görülmüştür.
İÇGİRİŞİMCİ DAVRANIŞI: ÖLÇEK GELİŞTİRME, GÜVENİLİRLİK VE GEÇERLİLİK ÇALIŞMASI
Authors: SEZGİN Oytun 
Published: January 2020

Bağlı bulundukları kurumlardaki bireylerin teşvikler ya da kendi
inisiyatifleri doğrultusunda, bulundukları kurumdan ayrılmadan
gerçekleştirdikleri girişimsel faaliyetler bütünü şeklinde tanımlanan
içgirişimci davranışı, işletmelerin rekabet avantajı elde etmesine katkıda
bulunmaktadır. İlgili yazında işletmeler açısından önem arz eden içgirişimci
davranışı olgusunun, bütüncül değerlendirilerek geliştirilen bir ölçek
eksikliği dikkat çekmektedir. Bu çalışmanın amacı, içgirişimci olgusunun bütün
boyutları ile değerlendirerek içgirişimci davranışı için bir ölçme aracı
geliştirmektir. Bu bağlamda çalışma;
kapsam geçerliliği, yapı geçerliliği ve ölçek güvenilirliği aşamalarını
içermektedir.

Çalışmada oluşturulan 23 maddelik soru formu İzmir’deki özel sektörde
çalışan 207 kişi üzerinde test edilmiştir. Gerçekleştirilen açımlayıcı ve
doğrulayıcı faktör analizleri sonucunda içgirişimci davranışı ölçeği; yenilikçilik,
rekabetçilik, destekleyicilik, inisiyatif alma, bilgi edinimi ve proaktiflik
olmak üzere 6 boyuttan oluşmaktadır. Geliştirilen ölçeğin ilgili yazına ve
olgunun algılanmasına dönük yapılacak açıklayıcı çalışmalara katkı sağlayacağı
düşünülmektedir. Ayrıca, özgün bir ölçek ile gerçekleştirilen çalışmaların da
politika yapıcılara ve uygulamacılara destek olması beklenmektedir.
MOBİL REKLAMLARA YÖNELİK TUTUM VE DAVRANIŞLAR: ÜNİVERSİTE ÖĞRENCİLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: KAHRAMAN Aysun , GÜVEN Esra 
Published: January 2020

Yüksek hızlı
internet teknolojilerinin ortaya çıkması ve akıllı telefon kullanımının artması
reklam endüstrisini etkilemiş, mobil reklamlar medya kanalları arasında yerini
almıştır. Mobil reklam kampanyalarına
yönelik yatırımlar arttıkça bu alanda araştırma yapma ihtiyacı da artmaktadır.
Akıllı telefon ve mobil teknolojilere olan ilgilerinin yüksek olması nedeniyle özellikle
genç tüketicilerin aynı ilgiyi mobil reklamlara gösterip göstermediği merak
konusudur. Bu noktadan hareketle bu çalışmada üniversite öğrencilerinin mobil
reklamlara yönelik tutumları ve mobil reklamları benimseme davranışları
incelenmiştir. Mobil reklamları benimsemeyi etkileyeceği düşünülen
değişkenlerden yola çıkarak bir model oluşturulmuştur. 360 üniversite
öğrencisinden anket yöntemiyle toplanan veriler SPSS 23.0 ve LISREL 9.30
programlarında analiz edilmiştir. Analiz sonuçlarına göre akıllı telefonlar en
çok müzik dinlemek, sosyal ağları takip etmek ve video izlemek amacıyla
kullanılmaktadır. Mobil reklamlara yönelik tutum olumsuzdur. Mobil reklamların
benimsenmesinde reklamların eğlenceli bulunmasının ve reklamlardan hoşlanmanın
doğrudan etkisi vardır. Mobil reklamları eğlenceli bulmak, mobil reklamların
faydalı olduğunu düşünmek mobil reklamlardan hoşlanmayı olumlu yönde
etkilerken, mobil reklamlardan rahatsızlık duymak hoşlanmayı olumsuz yönde
etkilemektedir.
Temel Duygusal Yüz İfadelerinin Zaman Algısı Üzerindeki Etkisi
Authors: ERDOĞAN Şengül , BARAN Zeynel 
Published: January 2020

Amaç: Bu çalışmanın amacı, evrensel olarak kabul edilen 6
temel duyguya ait yüz ifadelerinin sunum süresi değişimlenmesinin zaman algısı
üzerindeki etkisini, zaman aralığı yeniden oluşturma ve süreyi sözel tahmin
etme yöntemleri aracılığıyla incelemektir.Yöntem: Araştırma, dört farklı sunum süresinde (500, 1000, 1500
ve 2000 ms) sunulan yüz ifadelerinin (kızgınlık, korku, üzüntü, tiksinme,
şaşkınlık, mutluluk ve nötr) sözel olarak tahmin edilmesi ve yeniden
üretilmesini içeren iki farklı yöntemle 75 gönüllü öğrenci (47 Kadın ve 28
Erkek) ile yürütülmüştür.

Bulgular: Her bir sunum süresinde, tüm duygusal yüz ifadeleri
hedef süreye göre kısa algılanmakta ve sunum süresi artıkça zamansal bozulmalar
artmaktadır. Öte yandan, tüm duygusal yüz ifadeleri, üzüntü yüz ifadesi hariç,
nötr yüz ifadesinden daha uzun algılanmaktadır. Bununla birlikte, tüm uyarıcı
süreleri, zaman aralığı yeniden oluşturma görevinde, süreyi sözel tahmin etme
görevine göre daha uzun algılanmaktadır.Sonuç: İçsel saat modeli ile dikkat ve genel uyarılmışlık düzeyi bağlamında, yüz
ifadelerinin hedef süreye göre kısa algılanması dikkat kaynaklı modelle; nötre
göre daha uzun algılanması ise genel uyarılmışlık düzeyi kaynaklı modelle daha
uyumlu görünmektedir. Duygusal yüz ifadelerinin zaman algısı üzerindeki
etkisinde, genel uyarılmışlık düzeyi ve dikkat kaynaklı ortak etkilerin yanı
sıra, zamansal yöntem türlerindeki farklılıklardan kaynaklanan bellek ve karar
verme süreçleri de etkili olabilmektedir.