bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normalization of a conversation tool to promote shared decision making about anticoagulation in patients with atrial fibrillation within a practical randomized trial of its effectiveness: a cross-sectional study
Authors:   Shared Decision Making for Atrial Fibrillation (SDM4AFib) Trial Investigators, Spencer-Bonilla Gabriela , Thota Anjali , Organick Paige , Ponce Oscar J. , Kunneman Marleen , Giblon Rachel , Branda Megan E. , Sivly Angela L. , Behnken Emma , May Carl R. , Montori Victor M. 
Published: May 2020

Abstract
Background
Shared decision making (SDM) implementation remains challenging. The factors that promote or hinder implementation of SDM tools for use during the consultation, including contextual factors such as clinician burnout and organizational support, remain unclear. We explored these factors in the context of a practical multicenter randomized trial evaluating the effectiveness of an SDM conversation tool for patients with atrial fibrillation considering anticoagulation therapy.

Methods
In this cross-sectional study, we recruited clinicians who were regularly involved in conversations with patients regarding anticoagulation for atrial fibrillation. Clinicians reported their characteristics and burnout symptoms using the two-item Maslach Burnout Inventory. Clinicians were trained in using the SDM tool, and they recorded their perceptions of the tool’s normalization potential using the Normalization MeAsure Development (NoMAD) survey instrument and verbally reflected on their answers to these survey questions. When possible, the training sessions and clinicians’ verbal responses to the conversation tool were recorded.

Results
Our study comprised 183 clinicians recruited into the trial (168 with survey responses and 112 with recordings). Overall, clinicians gave high scores to the normalization potential of the intervention; they endorsed all domains of normalization to the same extent, regardless of site, clinician characteristics, or burnout ratings. In interviews, clinicians paid significant attention to making sense of the tool. Tool buy-in seemed to depend heavily on their ability to see the tool as accurate and “evidence-based” and their perceptions of having time in the consultation to use it.

Conclusions
While time in the consultation remains a barrier, we did not find a significant association between burnout symptoms and normalization of an SDM conversation tool. Possible areas for improving the normalization of SDM conversation tools in clinical practice include enabling collaboration among clinicians to implement the tool and reporting how clinicians elsewhere use the tool. Direct measures of normalization (i.e., observing how often clinicians access the tool in practice outside of the clinical trial) may further elucidate the role that contextual factors, such as clinician burnout, play in the implementation of SDM.

Trial registration
ClinicalTrials.gov, NCT02905032. Registered on 9 September 2016.
Access to routinely collected health data for clinical trials – review of successful data requests to UK registries
Authors: Lensen Sarah , Macnair Archie , Love Sharon B. , Yorke-Edwards Victoria , Noor Nurulamin M. , Martyn Meredith , Blenkinsop Alexandra , Diaz-Montana Carlos , Powell Graham , Williamson Elizabeth , Carpenter James , Sydes Matthew R. 
Published: May 2020

Abstract
Background
Clinical trials generally each collect their own data despite routinely collected health data (RCHD) increasing in quality and breadth. Our aim is to quantify UK-based randomised controlled trials (RCTs) accessing RCHD for participant data, characterise how these data are used and thereby recommend how more trials could use RCHD.

Methods
We conducted a systematic review of RCTs accessing RCHD from at least one registry in the UK between 2013 and 2018 for the purposes of informing or supplementing participant data. A list of all registries holding RCHD in the UK was compiled. In cases where registries published release registers, these were searched for RCTs accessing RCHD. Where no release register was available, registries were contacted to request a list of RCTs. For each identified RCT, information was collected from all publicly available sources (release registers, websites, protocol etc.). The search and data extraction were undertaken between January and May 2019.

Results
We identified 160 RCTs accessing RCHD between 2013 and 2018 from a total of 22 registries; this corresponds to only a very small proportion of all UK RCTs (about 3%). RCTs accessing RCHD were generally large (median sample size 1590), commonly evaluating treatments for cancer or cardiovascular disease. Most of the included RCTs accessed RCHD from NHS Digital (68%), and the most frequently accessed datasets were mortality (76%) and hospital visits (55%). RCHD was used to inform the primary trial (82%) and long-term follow-up (57%). There was substantial variation in how RCTs used RCHD to inform participant outcome measures. A limitation was the lack of information and transparency from registries and RCTs with respect to which datasets have been accessed and for what purposes.

Conclusions
In the last five years, only a small minority of UK-based RCTs have accessed RCHD to inform participant data. We ask for improved accessibility, confirmed data quality and joined-up thinking between the registries and the regulatory authorities.

Trial registration
PROSPERO CRD42019123088.
Individualized treatment for acute Achilles tendon rupture based on the Copenhagen Achilles Rupture Treatment Algorithm (CARTA): a study protocol for a multicenter randomized controlled trial
Authors: Hansen Maria Swennergren , Vestermark Marianne Toft , Hölmich Per , Kristensen Morten Tange , Barfod Kristoffer Weisskirchner 
Published: May 2020

AbstractBackgroundAn individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm (CARTA)) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to investigate if this individualized treatment algorithm gives a better functional outcome than treating all patients either operatively or non-operatively per default.Methods/designThis study is conducted as a multicenter, three-armed randomized controlled trial. Participants are included from four hospitals in Denmark and randomized 1:1:1 to one of three parallel groups: 1) Intervention group—participants are treated according to an individualized treatment algorithm; 2) Control group A—participants are treated non-operatively; 3) Control group B—participants are treated operatively. The individualized treatment algorithm for the intervention group is based on an ultrasonographic examination; tendon overlap and elongation below 7% is to be treated non-operatively, while no tendon overlap and/or elongation above 7% will be treated operatively. Over a period of 3 years, 300 participants will be included. The primary outcome is the heel-rise work test at 12 months post-injury. Secondary outcomes are tendon elongation, the Achilles tendon Total Rupture Score (ATRS), the rate of re-ruptures, and other complications. The primary analysis will be conducted as an intention-to-treat analysis.DiscussionThis trial will indicate if treatment of acute Achilles tendon rupture can be individualized based on elongation and tendon overlap. It is hypothesized that different patients will benefit from different treatments instead of offering all the same treatment.Trial registrationClinicalTrials.gov,NCT03525964. Registered 16 May 2018.
Study on a susceptible–exposed–infected–recovered model with nonlinear incidence rate
Authors: Chen Lijun , Wei Fengying 
Published: May 2020

AbstractA stochastic susceptible–exposed–infected–recovered (SEIR) model with nonlinear incidence rate is investigated. Under suitable conditions, existence and uniqueness of a global solution, stationary distribution with ergodicity, persistence in the mean, and extinction of the disease are obtained. Numerical simulations and conclusions are separately carried out at the end of this paper.
The association between FTO rs9939609 gene polymorphism and anthropometric indices in adults
Authors: Mehrdad Mahsa , Fardaei Majid , Fararouei Mohammad , Eftekhari Mohammad Hassan 
Published: May 2020

Abstract
Background
Fat mass and obesity-associated gene (FTO) is the most studied obesity-related gene up to date. We aimed to assess anthropometric indices in carriers of FTO rs9939609 polymorphism with overweight across Iranian population (Shiraz) to find out the associations of this polymorphism with obesity indices.

Methods
This was a cross-sectional study conducted on 198 overweight healthy adults aged 20-45 years old. We assessed the body composition of the participants using bioelectrical impedance analyzer. In addition, we measured the waist circumference (WC) and hip circumference (HC). Waist to hip ratio (WHR) and waist to height ratio (WHtR) were also calculated by equations. The participants’ genotype was determined by ARMS-PCR. Also, data analysis was performed using SPSS software version 20 and R software version 3.6.2.

Results
The mean values of body mass index (BMI) and age of the participants were 26.93 ± 1.13 kg/m2 and 33.33 ± 6.35 years old, respectively. Homozygous carriers of A-allele had significantly higher values for BMI (0.60 kg/m2, p = 0.026), WHR (0.04 unit, p = 0.003), and WHtR (0.02 unit, p = 0.030) than the homozygous carriers of T-allele. Individuals with AA genotype had greater WC (2.66 cm, p = 0.042, and 4.03 cm, p = 0.002), fat mass (2.24 kg, p = 0.004, and 3.02 kg, p = 0.001), and trunk fat (1.53 kg, p = 0.001, and 2.08 kg, p = 0.001) compared to those with AT and TT genotypes, respectively. Interestingly, after adjustment of the confounders, significant associations were observed among rs9939609 polymorphism and BMI, Wt, WC, trunk fat percentage, WHR, and WHtR.

Conclusions
A-allele of the FTO rs9939609 polymorphism was indicated to be associated with greater general and central obesity in adult population of Shiraz, Iran.
Further rejection of the cybercrime hypothesis
Authors: Farrell Graham , Birks Daniel 
Published: May 2020

AbstractWe recently rejected the hypothesis that increases in cybercrime may have caused the international crime drop. Critics subsequently argued that offenders switched from physical crime to cybercrime in recent years, and that lifestyle changes due to ‘leisure IT’ may have caused the international crime drop. Here we explain how the critics misrepresented our argument and do not appear to introduce anything new.
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model
Authors: Abe Yoichiro , Ikegawa Natsumi , Yoshida Keitaro , Muramatsu Kyosuke , Hattori Satoko , Kawai Kenji , Murakami Minetaka , Tanaka Takumi , Goda Wakami , Goto Motohito , Yamamoto Taichi , Hashimoto Tadafumi , Yamada Kaoru , Shibata Terumasa , Misawa Hidemi , Mimura Masaru , Tanaka Kenji F. , Miyakawa Tsuyoshi , Iwatsubo Takeshi , Hata Jun-ichi , Niikura Takako , Yasui Masato 
Published: May 2020

AbstractAquaporin-4 (AQP4) has been suggested to be involved in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD), which may be due to the modulation of neuroinflammation or the impairment of interstitial fluid bulk flow system in the central nervous system. Here, we show an age-dependent impairment of several behavioral outcomes in 5xFAD AQP4 null mice. Twenty-four-hour video recordings and computational analyses of their movement revealed that the nighttime motion of AQP4-deficient 5xFAD mice was progressively reduced between 20 and 36 weeks of age, with a sharp deterioration occurring between 30 and 32 weeks. This reduction in nighttime motion was accompanied by motor dysfunction and epileptiform neuronal activities, demonstrated by increased abnormal spikes by electroencephalography. In addition, all AQP4-deficient 5xFAD mice exhibited convulsions at least once during the period of the analysis. Interestingly, despite such obvious phenotypes, parenchymal amyloid β (Aβ) deposition, reactive astrocytosis, and activated microgliosis surrounding amyloid plaques were unchanged in the AQP4-deficient 5xFAD mice relative to 5xFAD mice. Taken together, our data indicate that AQP4 deficiency greatly accelerates an age-dependent deterioration of neuronal function in 5xFAD mice associated with epileptiform neuronal activity without significantly altering Aβ deposition or neuroinflammation in this mouse model. We therefore propose that there exists another pathophysiological phase in AD which follows amyloid plaque deposition and neuroinflammation and is sensitive to AQP4 deficiency.
Causal relations on a cline of explicitness: an SFL perspective
Authors: Othman Waleed 
Published: May 2020

AbstractThis paper is an attempt to categorize cause-effect relations in English in terms of explicitness on the basis of realisation and choice. Specifically, making use of SFL’s concept of grammatical metaphor and the dimension of delicacy, I suggest that cause-effect relations can be placed on a cline with respect to how explicitly they encode logico-semantic meaning.
Bioethanol from hydrolyzed Spirulina (Arthrospira platensis) biomass using ethanologenic bacteria
Authors: Werlang Eliana B. , Julich Jennifer , Muller Maria V. G. , de Farias Neves Fabio , Sierra-Ibarra Estefanía , Martinez Alfredo , Schneider Rosana de C. de S. 
Published: May 2020

AbstractPhotosynthetic microorganisms are considered excellent feedstock for biofuel production in developing biomass production technologies. A study was conducted to evaluate ethanol production with the sequential enzymatic saccharification and fermentation of Arthrospira platensis (Spirulina) biomass with the metabolically engineered Escherichia coli strain MS04. A. platensis was cultivated semicontinuously in an open raceway pond, and the carbohydrate content was determined to be as high as 40%. The enzymatic saccharification was designed to release the maximum amount of glucose. After 40 h of enzymatic saccharification, 27 g L−1 of monosaccharides was obtained. These slurries were fermented with ethanologenic bacteria, achieving 12.7 g L−1 ethanol after 9 h of fermentation, which corresponds to 92% conversion yield of the glucose content in the hydrolysate, 0.13 g of ethanol per 1 g of Spirulina biomass and a volumetric productivity of 1.4 g of ethanol L−1 h−1. Therefore, we conclude that it is possible, in a short time, to obtain a high ethanol yield corresponding to 160 L per ton of dry biomass with a high productivity.
True cicadas (Cicadidae) as prey for the birds of the Western Palearctic: a review
Authors: Pons Pere 
Published: May 2020

Abstract
Background
True cicadas (Cicadidae) are large and temporarily abundant insects. Their availability may produce demographic and behavioural effects on bird populations, as happens with forest avifauna feeding on periodical cicadas in North America. In Europe, the Near East and North Africa, knowledge of cicada predation by birds is sparse.

Methods
To help fill this gap, I consulted Cramp’s Birds of the Western Palearctic, conducted a search of online databases and used search engines to generate a database of Western Palearctic birds known to eat cicadas.

Results
A total of 105 species (16% of those occurring in the region) belonging to 13 orders, and comprising 20 of the 33 passerine families, were found to consume cicadas. I estimated that 69 of these bird species are known to consume cicadas within the limits of the Western Palearctic. Many terrestrial birds predate on cicadas, preferably on adults. Avian predators include cuckoos, owls, bee-eaters, woodpeckers, falcons, reed-warblers, larks, crows and jays, buntings, shrikes, pipits and wagtails, flycatchers and chats, tits, sparrows, leaf-warblers, starlings, warblers and thrushes, but also terns and gulls. Nymphs are consumed by some passerines, owls and herons. Cicadas can make up as much as 70% of food items delivered to nestlings. Analysis of stomach contents and neck collar samples are the most common methods used in diet studies.

Conclusions
Available knowledge is biased towards species that have been more intensively studied, and often lack proper quantification of prey items. More studies about the relative importance of cicadas as prey for birds in the Western Palearctic are needed. I suggest using non-invasive studies based on pellets and droppings and prioritizing declining bird species.
Optimization of [18F]PSMA-1007 PET-CT using regularized reconstruction in patients with prostate cancer
Authors: Trägårdh Elin , Minarik David , Brolin Gustav , Bitzén Ulrika , Olsson Berit , Oddstig Jenny 
Published: May 2020

Abstract
Background
Prostate-specific membrane antigen (PSMA) radiotracers such as [18F]PSMA-1007 used with positron emission tomography-computed tomography (PET-CT) is promising for initial staging and detection of recurrent disease in prostate cancer patients. The block-sequential regularization expectation maximization algorithm (BSREM) is a new PET reconstruction algorithm, which provides higher image contrast while also reducing noise. The aim of the present study was to evaluate the influence of different acquisition times and different noise-suppressing factors in BSREM (β values) in [18F]PSMA-1007 PET-CT regarding quantitative data as well as a visual image quality assessment.
We included 35 patients referred for clinical [18F]PSMA-1007 PET-CT. Four megabecquerels per kilogramme were administered and imaging was performed after 120 min. Eighty-four image series per patient were created with combinations of acquisition times of 1–4 min/bed position and β values of 300–1400. The noise level in normal tissue and the contrast-to-noise ratio (CNR) of pathological uptakes versus the local background were calculated. Image quality was assessed by experienced nuclear medicine physicians.

Results
The noise level in the liver, spleen, and muscle was higher for low β values and low acquisition times (written as activity time products (ATs = administered activity × acquisition time)) and was minimized at maximum AT (16 MBq/kg min) and maximum β (1400). There was only a small decrease above AT 10. The median CNR increased slowly with AT from approximately 6 to 12 and was substantially lower at AT 4 and higher at AT 14–16. At AT 4–6, many images were regarded as being of unacceptable quality. For AT 8, β values of 700–900 were considered of acceptable quality.

Conclusions
An AT of 8 (for example as in our study, 4 MB/kg with an acquisition time of 2 min) with a β value of 700 performs well regarding noise level, CNR, and visual image quality assessment.
Impact of the Bayesian penalized likelihood algorithm (Q.Clear®) in comparison with the OSEM reconstruction on low contrast PET hypoxic images
Authors: Texte Edgar , Gouel Pierrick , Thureau Sébastien , Lequesne Justine , Barres Bertrand , Edet-Sanson Agathe , Decazes Pierre , Vera Pierre , Hapdey Sébastien 
Published: May 2020

Abstract
Purpose
To determine the impact of the Bayesian penalized likelihood (BPL) reconstruction algorithm in comparison to OSEM on hypoxia PET/CT images of NSCLC using 18F-MIZO and 18F-FAZA.

Materials and methods
Images of low-contrasted (SBR = 3) micro-spheres of Jaszczak phantom were acquired. Twenty patients with lung neoplasia were included. Each patient benefitted from 18F-MISO and/or 18F-FAZA PET/CT exams, reconstructed with OSEM and BPL. Lesion was considered as hypoxic if the lesion SUVmax > 1.4. A blind evaluation of lesion detectability and image quality was performed on a set of 78 randomized BPL and OSEM images by 10 nuclear physicians. SUVmax, SUVmean, and hypoxic volumes using 3 thresholding approaches were measured and compared for each reconstruction.

Results
The phantom and patient datasets showed a significant increase of quantitative parameters using BPL compared to OSEM but had no impact on detectability. The optimal beta parameter determined by the phantom analysis was β350. Regarding patient data, there was no clear trend of image quality improvement using BPL. There was no correlation between SUVmax increase with BPL and either SUV or hypoxic volume from the initial OSEM reconstruction. Hypoxic volume obtained by a SUV > 1.4 thresholding was not impacted by the BPL reconstruction parameter.

Conclusion
BPL allows a significant increase in quantitative parameters and contrast without significantly improving the lesion detectability or image quality. The variation in hypoxic volume by BPL depends on the method used but SUV > 1.4 thresholding seems to be the more robust method, not impacted by the reconstruction method (BPL or OSEM).

Trial registration
ClinicalTrials.gov, NCT02490696. Registered 1 June 2015
The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial
Authors: O’Dowd Hazel , Beasant Lucy , Ingram Jenny , Montgomery Alan , Hollingworth Will , Gaunt Daisy , Collin Simon M. , Horne Sarah , Jones Beth , Crawley Esther 
Published: May 2020

Abstract
Background
Chronic fatigue syndrome (CFS, also known as myalgic encephalomyelitis (ME)) is defined as fatigue that is disabling, is accompanied by additional symptoms and persists for ≥ 4 months. Treatment of CFS/ME aims to help patients manage their symptoms and make lifestyle adjustments. We do not know whether intervening early in primary care (< 4 months after onset of fatigue) can prevent the development of CFS/ME.

Methods
This was a feasibility randomised controlled trial with adults (age ≥ 18 years) comparing usual care with usual care plus an early intervention (EI; a combination of psycho-education and cognitive behavioural therapy, CBT). This study took place in fourteen primary care practices in Bristol, England and aimed to identify issues around recruitment and retention for a full-scale trial. It was not powered to support statistical analysis of differences in outcomes. Integrated qualitative methodology was used to explore the feasibility and acceptability of recruitment and randomisation to the intervention.

Results
Forty-four patients were recruited (1 August 2012–November 28, 2013), falling short of our predicted recruitment rate of 100 patients in 8 months. Qualitative data from GPs showed recruitment was not feasible because it was difficult to identify potential participants within 4 months of symptom onset. Some referring GPs felt screening investigations recommended by NICE were unnecessary, and they had difficulty finding patients who met the eligibility criteria. Qualitative data from some participant interviews suggested that the intervention was not acceptable in its current format. Although the majority of participants found parts of the intervention acceptable, many reported one or more problems with acceptability. Participants who discontinued the intervention or found it problematic did not relate to the therapeutic model, disliked telephone consultations or found self-reflection challenging.

Conclusions
A randomised controlled trial to test an early intervention for fatigue in adults in primary care is not feasible using this intervention and recruitment strategy.

Trial registration
International Standard Randomised Controlled Trials, ISRCTN72645894. Retrospectively registered on 17 May 2013