bluuebunny/crossref_metadata_2025_split huggingface dataset:
The extracellular volume status predicts body fluid response to SGLT2 inhibitor dapagliflozin in diabetic kidney disease
Authors: Ohara Ken , Masuda Takahiro , Morinari Masato , Okada Mari , Miki Atsushi , Nakagawa Saki , Murakami Takuya , Oka Kentaro , Asakura Maki , Miyazawa Yasuharu , Maeshima Akito , Akimoto Tetsu , Saito Osamu , Nagata Daisuke 
Published: May 2020

AbstractBackgroundSodium–glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic action. We recently reported that the SGLT2 inhibitor dapagliflozin ameliorates extracellular volume expansion with a mild increase in urine volume. However, the impact of the pretreatment extracellular volume status on the body fluid response to SGLT2 inhibitors remains unclear.MethodsThirty-six diabetic kidney disease (DKD) patients were treated with dapagliflozin. The body fluid volume, including intracellular water (ICW), extracellular water (ECW) and total body water (TBW), were measured on baseline and day 7 using a bioimpedance analysis (BIA) device. The ECW/TBW and ECW were used as markers of the extracellular volume status. For a comparison, the extracellular volume status responses to loop diuretic furosemide (n = 16) and vasopressin V2 receptor antagonist tolvaptan (n = 13) were analyzed.ResultsThe body weight, brain natriuretic peptide and body fluid parameters measured by a BIA (ICW, ECW, TBW, and ECW/TBW) were significantly decreased for 1 week after dapagliflozin administration. The change in the ECW/TBW in the high-ECW/TBW group (over the median value of 0.413) was significantly higher than in the low-ECW/TBW group (− 2.1 ± 0.4 vs. − 0.5 ± 0.4%,p = 0.006). Only with dapagliflozin treatment (not furosemide or tolvaptan treatment) was the baseline ECW/TBW significantly correlated with the changes in the ECW/TBW (r = − 0.590,p < 0.001) and ECW (r = − 0.374,p = 0.025).ConclusionsThe pretreatment extracellular volume status predicts the body fluid response to the SGLT2 inhibitor dapagliflozin in DKD patients. The diminished extracellular fluid reduction effect of dapagliflozin in patients without severe extracellular fluid retention may contribute to maintaining a suitable body fluid status.
A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients
Authors: Sosuan George Michael N. , Ranche Felice Katrina T. , Lagunzad John Kenneth D. 
Published: May 2020

Abstract
Objectives
The study aimed to determine the effect of oxymetazoline nasal spray on the patency of the fistula created after dacryocystorhinostomy, specifically: to compare the success of fistula formation with oxymetazoline versus placebo, and to compare the incidence of post-operative congestion, pain and bleeding with oxymetazoline versus placebo.

Results
The study was a single-center, randomized controlled, triple-masked study involving the patients of the Plastic-Lacrimal service of a national university hospital. Block randomization was done. Dacryocystorhinostomy was performed by a single-masked surgeon. The intervention group used oxymetazoline. The placebo group used sodium chloride. The data were collected by another masked investigator. The study showed no significant difference in terms of congestion, pain and epistaxis between the two groups at day 2 post-operation. The patency, presence of silicone tube, granuloma formation, and presence of bleeding on both day 2 and day 16 post-operation had no difference between the two groups. This study doesn’t support the use of oxymetazoline nasal spray after DCR, since it does not decrease the symptoms of congestion, pain and epistaxis after DCR. Aside from being an additional expense for patients, it also does not affect fistula formation and success rate of the surgery.
Trial registration Australian New Zealand Clinical Trial Registry: ACTRN12619001394134, Date registered 10/11/2019, Retrospectively Registered.
Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma
Authors: Aguiar Fabio S. , Melo André S. , Araújo Ana Maria S. , Cardoso Alexandre P. , de Souza Sergio Augusto L. , Lopes-Pacheco Miquéias , Cruz Fernanda F. , Xisto Debora G. , Asensi Karina D. , Faccioli Lanuza , Salgado Anna Beatriz S. , Landesmann Maria Carolina P. P. , Goldenberg Regina C. S. , Gutfilen Bianca , Morales Marcelo M. , Rocco Patricia R. M. , Lapa e Silva Jose R. 
Published: May 2020

Abstract
Background
Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting β2-adrenoceptor agonists results in disease control for many patients, but those who exhibit severe asthma are often unresponsive to conventional treatment, experiencing worse quality of life, frequent exacerbations, and increasing healthcare costs. Bone marrow-derived mononuclear cell (BMMC) transplantation has been shown to reduce airway inflammation and remodeling and improve lung function in experimental models of allergic asthma.

Methods
This is a case series of three patients who presented severe asthma, unresponsive to conventional therapy and omalizumab. They received a single intravenous dose of autologous BMMCs (2 × 107) and were periodically evaluated for 1 year after the procedure. Endpoint assessments included physical examination, quality of life questionnaires, imaging (computed tomography, single-photon emission computed tomography, and ventilation/perfusion scan), lung function tests, and a 6-min walk test.

Results
All patients completed the follow-up protocol. No serious adverse events attributable to BMMC transplantation were observed during or after the procedure. Lung function remained stable throughout. A slight increase in ventilation of the right lung was observed on day 120 after BMMC transplantation in one patient. All three patients reported improvement in quality of life in the early post-procedure course.

Conclusions
This paper described for the first time the effects of BMMC therapy in patients with severe asthma, providing a basis for subsequent trials to assess the efficacy of this therapy.
MFsim—an open Java all-in-one rich-client simulation environment for mesoscopic simulation
Authors: van den Broek Karina , Daniel Mirco , Epple Matthias , Hein Jan-Mathis , Kuhn Hubert , Neumann Stefan , Truszkowski Andreas , Zielesny Achim 
Published: May 2020

AbstractMFsim is an open Java all-in-one rich-client computing environment for mesoscopic simulation with Jdpd as its default simulation kernel for Molecular Fragment (Dissipative Particle) Dynamics. The new environment comprises the complete preparation-simulation–evaluation triad of a mesoscopic simulation task and especially enables biomolecular simulation tasks with peptides and proteins. Productive highlights are a SPICES molecular structure editor, a PDB-to-SPICES parser for particle-based peptide/protein representations, a support of polymer definitions, a compartment editor for complex simulation box start configurations, interactive and flexible simulation box views including analytics, simulation movie generation or animated diagrams. As an open project, MFsim allows for customized extensions for different fields of research.
Disclosing Main authors and Organisations collaborations in bioprinting through network maps analysis
Authors: García-García Leonardo Azael , Rodríguez-Salvador Marisela 
Published: May 2020

Abstract
Background
Scientific activity for 3D bioprinting has increased over the past years focusing mainly on fully functional biological constructs to overcome issues related to organ transplants. This research performs a scientometric analysis on bioprinting based on a competitive technology intelligence (CTI) cycle, which assesses scientific documents to establish the publication rate of science and technology in terms of institutions, patents or journals. Although analyses of publications can be observed in the literature, the identification of the most influential authors and affiliations has not been addressed. This study involves the analysis of authors and affiliations, and their interactions in a global framework. We use network collaboration maps and Betweenness Centrality (BC) to identify of the most prominent actors in bioprinting, enhancing the CTI analysis.

Results
2088 documents were retrieved from Scopus database from 2007 to 2017, disclosing an exponential growth with an average publication increase of 17.5% per year. A threshold of five articles with ten or more cites was established for authors, while the same number of articles but cited five or more times was set for affiliations. The author with more publications was Atala A. (36 papers and a BC = 370.9), followed by Khademhosseini A. (30 documents and a BC = 2104.7), and Mironov (30 documents and BC = 2754.9). In addition, a small correlation was observed between the number of collaborations and the number of publications. Furthermore, 1760 institutions with a median of 10 publications were found, but only 20 within the established threshold. 30% of the 20 institutions had an external collaboration, and institutions located in and close to the life science cluster in Massachusetts showed a strong cooperation. The institution with more publications was the Harvard Medical School, 61 publications, followed by the Brigham and Women’s hospital, 46 papers, and the Massachusetts Institute of Technology with 37 documents.

Conclusions
Network map analysis and BC allowed the identification of the most influential authors working on bioprinting and the collaboration between institutions was found limited. This analysis of authors and affiliations and their collaborations offer valuable information for the identification of potential associations for bioprinting researches and stakeholders.
Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies
Authors: Cubillos-Zapata Carolina , Angulo Iván , Almanza Horacio , Borrego Belén , Zamora-Ceballos María , Castón José R. , Mena Ignacio , Blanco Esther , Bárcena Juan 
Published: May 2020

AbstractWe report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5′HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recognized by non-neutralizing MAbs; and a second epitope spanning amino acids 445-451 (ITTANQY), highly variable and recognized by neutralizing MAbs. These antibodies might be valuable for diagnostic applications, as well as for further research in different aspects of the biology of FCV.
Target tracking algorithm combined part-based and redetection for UAV
Authors: He Qiusheng , Zhang Weifeng , Chen Wei , Xie Gang , Yao Yanxin 
Published: May 2020

AbstractIn the process of target tracking for UAV video images, the performance of the tracking algorithm declines or even the tracking fails due to target occlusion and scale variation. This paper proposes an improved target tracking algorithm based on the analysis of the tracking framework of the kernel correlation filter. First, four subblocks around the center of the target center are divided. A correlation filter fusing Histogram of Oriented Gradient (HOG) feature and Color Name (CN) feature tracks separately each target subblocks. According to the spatial structure characteristics in the subblocks, the center location and scale of the target are estimated. Secondly, the correct center location of target is determined by the global filter. Then, a tracking fault detection method is proposed. When tracking fails, the target redetection module which uses the normalized cross-correlation algorithm (NCC) to obtain the candidate target set in the re-detection area is started. Besides, this algorithm uses the global filter to obtain real target from the candidate set. In the meanwhile, this algorithm adjusts sectionally the learning rate of the classifiers according to detection results. Lastly, the performance of this algorithm is verified on the UAV123 dataset. The results show that compared with several mainstream methods, that of this algorithm is significantly improved when dealing with target scale variation and occlusion.
Stability result of a viscoelastic plate equation with past history and a logarithmic nonlinearity
Authors: Al-Mahdi Adel M. 
Published: May 2020

AbstractIn this paper, we are concerned with the decay rate of the solution of a viscoelastic plate equation with infinite memory and logarithmic nonlinearity. We establish an explicit and general decay rate results with imposing a minimal condition on the relaxation function. In fact, we assume that the relaxation function h satisfies $$ h^{\prime}(t)\le-\xi(t) H\bigl(h(t)\bigr),\quad t\geq0, $$h′(t)≤−ξ(t)H(h(t)),t≥0, where the functions ξ and H satisfy some conditions. Our proof is based on the multiplier method, convex properties, logarithmic inequalities, and some properties of integro-differential equations. Moreover, we drop the boundedness assumption on the history data, usually made in the literature. In fact, our results generalize, extend, and improve earlier results in the literature.
A security event description of intelligent applications in edge-cloud environment
Authors: Li Qianmu , Yin Xiaochun , Meng Shunmei , Liu Yaozong , Ying Zijian 
Published: May 2020

AbstractIn traditional network environment, the attack topology of the network is usually obtained based on a graph traversal algorithm. It uses connection relationships to describe the process of the attack, thus completing the description of network security event. However, in the edge-cloud environment, the control logic and data forwarding of network devices are separated from each other. The control layer is responsible for the centralized management of network edge nodes. After acquiring the entire network topology, it can automatically generate a visualized network structure. This architecture extends traditional cloud computing architecture to the edge of the network, helping to handle some latency-sensitive service requirements, especially for most IoT applications. Therefore, security analysts can grasp the connection status of the devices on the entire network in the control domain. This network topology generation method based on the control layer information is directly and efficiently, which can greatly simplify the description of security events in the edge-cloud environment. At the same time, the separate structure also hides specific details of the underlying network device. Petri-net, as a formal description tool, can be used to describe such structure. Among existing security event description methods, the CORAS modeling tool has the advantages of graphical description, reusability and refinement description. And it also provides analysis guides to guide the operation steps. Based on the edge-cloud environment, this paper combines the advantages of CORAS modeling and analysis with Object-oriented Petri-net theory, and proposes a COP (CORAS-based Object-oriented Petri-net)-based Intelligent Applications security event description method. Experiments verify that this method is suitable for describing the complexity and dynamics of security events in edge cloud environment.
Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report
Authors: Miyatani Kozo , Miyauchi Wataru , Kono Yusuke , Shishido Yuji , Watanabe Joji , Hanaki Takehiko , Kihara Kyoichi , Matsunaga Tomoyuki , Yamamoto Manabu , Fukumoto Yoji , Tokuyasu Naruo , Takano Shuichi , Sakamoto Teruhisa , Honjo Soichiro , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: May 2020

Abstract
Background
Despite recent advances in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer still remains poor. Nonetheless, several efficacious intraperitoneal chemotherapy regimens have recently been developed for patients with peritoneal metastases. However, no study has investigated the effectiveness of intraperitoneal chemotherapy for metachronous peritoneal metastases from gastric cancer after curative surgery.

Case presentation
We herein report a case of a 65-year-old man who had metachronous peritoneal metastases from gastric cancer after curative total gastrectomy who had been successfully treated with intraperitoneal chemotherapy. One month after surgery, adjuvant chemotherapy with S-1 was initiated given a final pathological stage of IIIB (pT4aN2M0). However, during adjuvant chemotherapy 12 months after surgery, tumor marker levels, which had been within normal range before surgery, increased with abdominal contrast-enhanced computed tomography (CT) revealing pelvic ascites. Thereafter, staging laparoscopy was performed, and the patient was diagnosed with peritoneal recurrence of gastric cancer. Following staging laparoscopy, an intraperitoneal access port was subcutaneously implanted for subsequent intraperitoneal chemotherapy. Combined chemotherapy with intraperitoneal and intravenous administration of paclitaxel and oral S-1 was then provided. After one course of combined chemotherapy, peritoneal lavage cytology was negative for malignancy. CT showed gradually decreasing ascites, whereas tumor marker levels returned to normal. The patient continued chemotherapy without major side effects and remained progression-free for 33 months with 36 chemotherapy cycles.

Conclusions
A combination regimen including intraperitoneal chemotherapy could be a promising option for patients with peritoneal recurrence after gastric cancer surgery.
Highlights of the 2018 Chinese hypertension guidelines
Authors: Liu Jing 
Published: May 2020

Abstract
Background
Blood pressure (BP) are uncontrolled in over 80% hypertensive population in China, indicating a compelling need for a pragmatic hypertension management strategy. The 2018 Chinese hypertension guidelines issued in 2019, after 3 years revision. During the periods, the latest United States (US) and European guidelines successively published, bringing new thoughts, wisdoms and schemes on hypertension management. This review aims to summarize the highlights of the new Chinese guidelines.

Main text
Despite the fact that the 2017 US hypertension guidelines changed hypertension definition from ≥140/90 mmHg to 130/80 mmHg, the Chinese hypertension guidelines did not follow suit, and maintained 140/90 mmHg as the cut-point of for diagnosis of hypertension. A combined, cardiovascular risks and BP levels-based antihypertensive treatment algorithm was introduced. Five classes of antihypertensive drugs, including β-blockers were recommended as initiation and maintenance of BP-lowering therapy. Initiating combination therapy, including single pill combination (SPC) was indicated in high-risk patients or those with grade 2 or 3 hypertension. For those with grade 1 hypertension (BP ≥ 140/90 mmHg), an initial low-dose antihypertensive drugs combination treatment could be considered.

Conclusions
China has never stopped exploring the best strategy for improving hypertension control. Based on clinical evidence and expertise, the newest Chinese guidelines and expert consensus will be of help in guiding physicians and practitioners to provide better management of hypertension in China.
Interactions between Bacillus thuringiensis and entomophagous insects
Authors: Abbas Mohamed Samir Tawfik 
Published: May 2020

AbstractThe interactions between insect pathogens, parasitoids, and predators have been proposed as “intraguild predation (IGP).” It occurs when two species share a host or prey (and therefore may compete) or when they engage in a trophic interaction with each other (parasitism or predation). Laboratory studies revealed that many predacious species attack and consume Bacillus thuringiensis (Bt)-infected prey with no detrimental effects on the biological parameters of the predators. However, some studies indicated adverse impact of Bt on development and biology of the predators. As for parasitoids, some studies showed no detrimental effects on the biology of the parasitoids when reared on Bt-infected hosts and others revealed negative effects on their biological aspects. Such negative effects were found to be related to Bt concentration and timing of treatment (parasitism or infection). The biological parameters of the offspring of the adult parasitoids that had emerged from infected parasitized larvae were not affected. Also, ingestion of Bt by adult parasitoids did not affect the longevity or fecundity of such parasitoids. Concerning Bt crops, a recent published report in 2019 stated that over the past 20+ years, extensive experience and insight have been gained through laboratory and field studies of non-target effects of crops producing Cry proteins. Overall, the vast majority of the studies demonstrated that the insecticidal proteins developed today do not cause adverse effects on natural enemies (parasitoids and predators) of target pests.
Relapsed Wilms’ tumor in pediatric patients: challenges in low- to middle-income countries—a single-center experience
Authors: Zekri Wael , Yacoub Dalia M. , Ibrahim Asmaa , Madney Youssef 
Published: May 2020

Abstract
Background
Wilms’ tumor (WT) affects one in 10,000 children and accounts for 5% of all childhood cancers. Although the overall relapse rate for children with WT has decreased to less than 15 %, the overall survival for patients with recurrent disease remains poor at approximately 50 %. The aim of the study to evaluate the outcome of relapsed Wilms’ tumor pediatric patients treated at the National Cancer Institute (NCI), Egypt, between January 2008 and December 2015.

Results
One hundred thirty (130) patients diagnosed with WT during the study period, thirty (23%) patients had relapsed. The median follow up period was 22.3 months (range 3.6–140 months). The Overall Survival (OS) was 30.9% while the event-free survival (EFS) was 29.8% at a 5-year follow up period. Median time from diagnosis to relapse was 14.4 months. A second complete remission was attained in 18/30 patients (60%). The outcome of the 30 patients; 11 are alive and 19 had died. Three factors in our univariate analysis were prognostically significant for survival after relapse. The first was radiotherapy given after relapse (p = 0.012). The 5-year EFS and OS for the group that received radiotherapy were 41.9% versus 16.7% and 11.1% respectively for those that did not. The second was the state of lymph nodes among patients with local stage III (p = 0.004). Lastly, when risk stratification has been applied retrospectively on our study group, it proved to be statistically significant (p = 0.029).

Conclusion
Among relapsed pediatric WT, radiotherapy improved survival at the time of relapse and local stage III with positive lymph nodes had the worst survival among other stage III patients.