bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maestros de obras sin obras: talento perdido en la arquitectura española de finales del siglo XIX (ejemplos de profesionales titulados en Valladolid)
Authors: Domínguez Burrieza Francisco Javier 
Published: March 2020

<p>Tras la supresión de la enseñanza oficial de Maestro de Obras, el 30 de junio de 1869, surgieron las escuelas libres donde se titularon los últimos maestros de obras de España. Algunos no ejercieron, directamente, la arquitectura, obviando así el desarrollo de diseños arquitectónicos de nueva planta. Nos preguntamos por qué y si la hipotética falta de talento pudo ser la causa principal de la existencia de “maestros de obras sin obras”. Para ello, estudiamos los exámenes de reválida realizados por alumnos tanto de la Escuela Libre de Maestros de Obras de Valladolid como de la enseñanza oficial en la Academia de Bellas Artes de la Purísima (Valladolid) en sus últimos años. De sus aulas salieron muchos de los maestros de obras que trabajaron en parte del norte de España hasta, aproximadamente, los años treinta del siglo xx. En algunos autores apreciamos un talento que fue desaprovechado por diversas circunstancias.</p>
Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold
Authors: Al-Sanea Mohammad M. 
Published: March 2020

Background
CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and gastric cancers, were produced as a result of overexpression of CDK8/CycC in the mediator complex. Therefore, CDK8/CycC complex represents as a cancer oncogene and it has become a potential target for developing CDK8/CycC modulators.

Methods
A series of nine 4-phenylaminoquinoline scaffold-based compounds 5a-i was synthesized, and biologically evaluated as potential CDK8/CycC complex inhibitors.

Results
The scaffold substituent effects on the intrinsic inhibitory activity toward CDK8/CycC complex are addressed trying to present a novel outlook of CDK8/CycC Complex inhibitors with 4-phenylaminoquinoline scaffold in cancer therapy. The secondary benzenesulfonamide analogues proved to be the most potent compounds in suppressing CDK8/CycC enzyme, whereas, their primary benzenesulfonamide analogues showed inferior activity. Moreover, the benzene reversed sulfonamide analogues were totally inactive.

Discussion
The titled scaffold showed promising inhibitory activity data and there is a crucial role of un/substituted sulfonamido group for CDK8/CycC complex inhibitory activity. Compound 5d showed submicromolar potency against CDK8/CycC (IC50 = 0.639 µM) and it can be used for further investigations and to design another larger library of phenylaminoquinoline scaffold-based analogues in order to establish detailed SARs.
Nucleation and Growth of Colloidal Semiconductor Nanoparticles
Authors: Enright Michael J. , Ritchhart Andrew , Cossairt Brandi M. 
Published: March 2020

Abstract
Solution‐phase syntheses of semiconductor nanoparticles provide a versatile and scalable approach to obtain nanomaterials with desirable structure and function. The most common mechanism invoked to explain the nucleation and growth of colloidal semiconductor nanocrystals is the LaMer model, an extension of classical nucleation theory. This model is widely used to conceptualize the conversion of molecular precursors into nanoparticles, and is characterized by three stages: monomer buildup, nucleation, and particle growth. Each of these stages represents a fundamental aspect of nanoparticle synthesis, and each has been widely studied over the past several decades. One of the core successes of this model has been the prediction of the “burst nucleation” method, which has enabled the synthesis of monodisperse nanoparticles in many material systems. Increasingly, however, it has become apparent that many chemical systems do not follow classical nucleation theory, but rather grow via nonclassical cluster‐mediated or aggregative growth processes. Regardless of the nucleation mechanism, highly monodisperse semiconductor nanoparticles can be obtained through kinetic size focusing or digestive ripening. Kinetic size focusing occurs during the nanoparticle growth phase when monomer concentration is high and smaller particles grow faster than their larger counterparts, enabling the smaller particles to “catch up” in size to give a more monodisperse ensemble. Digestive ripening, on the other hand, is a postsynthetic strategy where additional ligand is provided to the system to etch larger particles and redistribute monomer to smaller particles to get a more uniform sample. Beyond the synthesis of spherical colloidal nanoparticles, procedures can be modified to achieve a range of anisotropic structures including 1D nanorods and 2D nanosheets. Seeded and templated growth strategies can lend additional synthetic flexibility to more easily access a range of complex architectures. Continued innovation in synthetic methods and mechanistic understanding will pave the way for technological translation and lasting impact across applications from biological imaging to catalysis and many other next‐generation technologies.
Dose deviations induced by respiratory motion for radiotherapy of lung tumors: Impact of CT reconstruction, plan complexity, and fraction size
Authors: Sande Erlend P. S. , Acosta Roa Ana M. , Hellebust Taran P. 
Published: March 2020

AbstractA thorax phantom was used to assess radiotherapy dose deviations induced by respiratory motion of the target volume. Both intensity modulated and static, non‐modulated treatment plans were planned on CT scans of the phantom. The plans were optimized using various CT reconstructions, to investigate whether they had an impact on robustness to target motion during delivery. During irradiation, the target was programmed to simulate respiration‐induced motion of a lung tumor, using both patient‐specific and sinusoidal motion patterns in three dimensions. Dose was measured in the center of the target using an ion chamber. Differences between reference measurements with a stationary target and dynamic measurements were assessed. Possible correlations between plan complexity metrics and measured dose deviations were investigated. The maximum observed motion‐induced dose differences were 7.8% and 4.5% for single 2 Gy and 15 Gy fractions, respectively. The measurements performed with the largest target motion amplitude in the superior–inferior direction yielded the largest dosimetric deviations. For 2 Gy fractionation schemes, the summed dose deviation after 33 fractions is likely to be less than 2%. Measured motion‐induced dose deviations were significantly larger for one CT reconstruction compared to all the others. Static, non‐modulated plans showed superior robustness to target motion during delivery. Moderate correlations between the modulation complexity score applied to VMAT (MCSv) and measured dose deviations were found for 15 Gy SBRT treatment plans. Correlations between other plan complexity metrics and measured dose deviations were not found.
Armoring LiNi1/3Co1/3Mn1/3O2 Cathode with Reliable Fluorinated Organic–Inorganic Hybrid Interphase Layer toward Durable High Rate Battery
Authors: Chen Yu , Zhao Weimin , Zhang Quanhai , Yang Guangzhi , Zheng Jianming , Tang Wei , Xu Qunjie , Lai Chunyan , Yang Junhe , Peng Chengxin 
Published: March 2020

AbstractTernary layered oxide materials have attracted extensive attention as a promising cathode candidate for high‐energy‐density lithium‐ion batteries. However, the undesirable electrochemical degradation at the electrode–electrolyte interface definitively shortens the battery service life. An effective and viable approach is proposed for improving the cycling stability of the LiNi1/3Co1/3Mn1/3O2 cathode using lithium difluorophosphate (LiPO2F2) paired with fuoroethylene carbonate (FEC) as co‐additives into conventional electrolytes. It is found that the co‐additives can greatly reduce the interface charge transfer impedance and significantly extend the life span of LiNi1/3Co1/3Mn1/3O2//Li (NMC//Li) batteries. The developed cathode demonstrates exceptional capacity retention of 88.7% and remains structural integrity at a high current of 5C after 500 cycles. Fundamental mechanism study indicates a dense, stable fluorinated organic–inorganic hybrid cathode‐electrolyte interphase (CEI) film derived from LiPO2F2 in conjunction with FEC additives on the surface of NMC cathode material, which significantly suppresses the decomposition of electrolyte and mitigates the dissolution of transition metal ions. The interfacial engineering of the electrode materials stabilized by the additives manipulation provides valuable guidance for the development of advanced cathode materials.
Controllable Growth of High‐Quality Inorganic Perovskite Microplate Arrays for Functional Optoelectronics
Authors: Gu Zhenkun , Zhou Zhonghao , Huang Zhandong , Wang Kang , Cai Zheren , Hu Xiaotian , Li Lihong , Li Mingzhu , Zhao Yong Sheng , Song Yanlin 
Published: March 2020

AbstractInorganic perovskite single crystals have emerged as promising vapor‐phase processable structures for optoelectronic devices. However, because of material lattice mismatch and uncontrolled nucleation, vapor‐phase methods have been restricted to random distribution of single crystals that are difficult to perform for integrated device arrays. Herein, an effective strategy to control the vapor‐phase growth of high‐quality cesium lead bromide perovskite (CsPbBr3) microplate arrays with uniform morphology as well as controlled location and size is reported. By introducing perovskite seeds on substrates, intractable lattice mismatches and random nucleation barriers are surpassed, and the epitaxial growth of perovskite crystals is accurately controlled. It is further demonstrated that CsPbBr3 microplate arrays can be monolithically integrated on substrates for the fabrication of high‐performance lasers and photodetectors. This strategy provides a facile approach to fabricate high‐quality CsPbBr3 microplates with controllable size and location, which offers new opportunities for the scalable production of integrated optoelectronic devices.
Nanoparticle‐Mediated Intracellular Protection of Natural Killer Cells Avoids Cryoinjury and Retains Potent Antitumor Functions
Authors: Yao Xue , Jovevski Joshua J. , Todd Michaela F. , Xu Rui , Li Yining , Wang Jiao , Matosevic Sandro 
Published: March 2020

AbstractThe ability of natural killer (NK) cells to mediate potent antitumor immunity in clinical adoptive transfer settings relies, in large part, on their ability to retain cytotoxic function following cryopreservation. To avoid potential systemic toxicities associated with infusions of NK cells into patients in the presence of dimethylsulfoxide (DMSO), interest in alternative cryoprotective agents (CPAs) with improved safety profiles has grown. Despite the development of various sugars, amino acids, polyols, and polyampholytes as cryoprotectants, their ability to promote protection from intracellular cryodamage is limited because they mostly act outside of the cell. Though ways to shuttle cryoprotectants intracellularly exist, NK cells' high aversity to manipulation and freezing has meant they are highly understudied as targets for the development of new cryopreservation approaches. Here, the first example of a safe and efficient platform for the intracellular delivery of non‐DMSO CPAs to NK cells is presented. Biocompatible chitosan‐based nanoparticles are engineered to mediate the efficient DMSO‐free cryopreservation of NK cells. NK cells cryopreserved in this way retain potent cytotoxic, degranulation, and cytokine production functions against tumor targets. This not only represents the first example of delivering nanoparticles to NK cells, but illustrates the clinical potential in manufacturing safer allogeneic adoptive immunotherapies “off the shelf.”
Factors associated with physical injury or police involvement during incidents of workplace violence in hospitals: Findings from the first year of California's new standard
Authors: Odes Rachel , Hong OiSaeng , Harrison Robert , Chapman Susan 
Published: March 2020

AbstractBackgroundWorkplace violence in healthcare settings is known to be a costly and often underreported problem. In California, hospitals are required to report incidents of violence towards workers to the California Occupational Safety and Health Administration (CalOSHA) using an online reporting system that went into effect in 2017.MethodsReports submitted to CalOSHA from July 2017 to September 2018 pursuant to this new requirement were analyzed using descriptive methods and logistic regression.ResultsFour hundred eight hospitals submitted reports using the new incident reporting system. Behavioral health units had 1.82 times the odds of the reported incident resulting in physical injury compared to inpatient medical units, and investor‐owned facilities had 2.43 times the odds of the reported incident resulting in physical injury compared to city or county‐owned facilities. Inpatient and behavioral health units had significantly reduced odds of a reported incident resulting in police involvement when compared to other locations within the hospital.ConclusionsThese findings indicate that protections for healthcare workers deserve ongoing attention from stakeholders and legislators and provide insight into how healthcare facilities report incidents of violence towards workers.
Mandibular symphyseal fusion in fossil primates: Insights from correlated patterns of jaw shape and masticatory function in living primates
Authors: Knigge Ryan P. , Vinyard Christopher J. , McNulty Kieran P. 
Published: March 2020

AbstractObjectivesVariation in primate masticatory form and function has been extensively researched through both morphological and experimental studies. As a result, symphyseal fusion in different primate clades has been linked to either the recruitment of vertically directed balancing‐side muscle force, the timing and recruitment of transversely directed forces, or both. This study investigates the relationship between jaw muscle activity patterns and morphology in extant primates to make inferences about masticatory function in extinct primates, with implications for understanding the evolution of symphyseal fusion.Materials and methodsThree‐dimensional mandibular landmark data were collected for 31 extant primates and nine fossil anthropoids and subfossil lemur species. Published electromyography (EMG) data were available for nine of the extant primate species. Partial least squares analysis and phylogenetic partial least squares analysis were used to identify relationships between EMG and jaw shape data and evaluate variation in jaw morphology.ResultsPrimates with partial and complete symphyseal fusion exhibit shape‐function patterns associated with the wishboning motor pattern and loading regime, in contrast to shape‐function patterns of primates with unfused jaws. All fossil primates examined (except Apidium) exhibit jaw morphologies suggestive of the wishboning motor pattern demonstrated in living anthropoids and indriids.DiscussionPartial fusion in Catopithecus, similar to indriids and some subfossil lemurs, may be sufficient to resist, or transfer, some amounts of transversely directed balancing‐side muscle force at the symphysis, representing a transition to greater reliance on transverse jaw movement during mastication. Furthermore, possible functional convergences in physiological patterns during chewing (i.e., Archaeolemur) are identified.
Diffuse midline glioma in the spinal cord with rapid respiratory deterioration
Authors: Kamidani Ryo , Okada Hideshi , Yasuda Ryu , Yoshida Takahiro , Kusuzawa Keigo , Ichihashi Masahiro , Kakino Yoshinori , Oiwa Hideaki , Kitagawa Yuichiro , Fukuta Tetsuya , Suzuki Kodai , Okamoto Haruka , Miyake Takahito , Tachi Masahito , Kanda Norihide , Iwai Chizuo , Shiba Masato , Yamada Noriaki , Nozawa Satoshi , Nakayama Noriyuki , Doi Tomoaki , Fushimi Kazunari , Yano Hirohito , Tomita Hiroyuki , Yoshida Shozo , Iwama Toru , Ogura Shinji 
Published: March 2020

BackgroundNeurogenic acute respiratory failure is usually caused by either infection or vascular insufficiency. We report the case of a patient who developed acute respiratory failure secondary to a spinal tumor.Case PresentationA 32‐year‐old man, presenting with numbness and muscle weakness in his legs for 2 weeks, was transferred to our hospital with worsening quadriplegia and development of respiratory symptoms. We carried out emergent spinal decompression and initiated steroid pulse therapy, with no resolution of symptoms; a tumor incision biopsy after contrast cervical magnetic resonance imaging revealed an intraspinal tumor with a pathological diagnosis of World Health Organization grade IV glioma. The patient developed bradycardia, severe sepsis, status epilepticus, and cardiopulmonary arrest due to hypoxemia and was treated with chemoradiotherapy under mechanical ventilation. He was later transferred to another hospital for subacute care.ConclusionAcute respiratory failure caused by spinal tumors is uncommon. However, acute care practitioners should be mindful of neoplastic lesions as a potential cause.
Forming and stripping of the wall film and the influence on gas–liquid separation
Authors: Yuan Shuxia , Fan Yuguang , Chen Bing , Li Jingming , Gao Lin , Zhang Shuo 
Published: March 2020

AbstractThe paper aims to investigate re‐entrainment mechanisms of wall films. The computational fluid dynamics method was adopted to study the gas–liquid separation process considering the wall film model. The interaction between the droplets and gas was solved by Euler–Lagrange method, whereas the forming and stripping of the wall film was studied by Eulerian wall film model. The results reveal that superficial velocity affects the re‐entrainment significantly, and there is a critical superficial velocity determining the occurrence of wall film stripping. According to this work, the critical velocity for air continuous phase is 11.2 m/s. It is found that the discrete phase content and droplet size have no effect on film thickness but affect the separation efficiency. The molecular viscosity and the density of continuous phase affect the Eulerian wall film on two aspects. First, the critical stripping velocity decreases with the increase in molecular viscosity. Second, the film average thickness and separation efficiency decrease with the increase in the product of viscosity and density of the continuous phase. Because the high velocity causes some unsteady of the results, the bulk velocities lower than 20 m/s are recommended. The development of re‐entrainment mechanism provides a good understanding of inertia separation.
Surface modification of nanocrystalline cellulose and its application in natural rubber composites
Authors: Jiang Weihui , Shen Peiyao , Yi Jinglin , Li Lin , Wu Chaojia , Gu Ju 
Published: March 2020

AbstractAs a biopolymer with high mechanical strength, nanocellulose was generally considered as a green filler for reinforcing polymer. In this study, nanocrystalline cellulose (NCC) isolated from softwood pulp was successfully modified by cetyltrimethyl ammonium bromide (CTMAB), a cationic surfactant, and the modified nanocrystalline cellulose (m‐NCC) was used to reinforce natural rubber (NR). In this composite architecture, it was found that when the filler content was 5 or 10 phr, the surface modification of NCC improved the dispersion state of NCC in NR matrix and the interfacial interaction between NR and NCC. Therefore, the NR/m‐NCC composites exhibited outstanding mechanical properties, and its tensile strength, elongation at break and tear strength was increased by 132.8, 20, and 66.1%, respectively, compared to pristine NR composites. Besides, the modified NCC could accelerate the vulcanization and improve wet‐skid resistance and aging resistance of NR composites. It is envisioned that the modified NCC has the potential to be generalized to manufacturing other polymer matrix composites strengthened with nanocellulose.
Determination of tylosin in milk samples by poly(ethylene terephthalate)‐based molecularly imprinted polymer
Authors: Garza Montelongo Elisa , Sánchez Anguiano María G. , Blanco Jerez Leonor M. , Pereira Ulloa Eduardo D. , Rivas Quiroz Bernabé L. , Elizondo Martínez Perla 
Published: March 2020

AbstractPoly(ethylene terephthalate)‐based molecularly imprinted polymers (MIPs) were synthesized, and their recognition capability was evaluated. Adsorption isotherm was described by the Langmuir model and the maximum adsorption capacity of MIPTy reached 172.4 mg g−1 in water at pH 6.2. A recognition coefficient of 1.17 was obtained. A solid‐phase extraction cartridge was manufactured and its behavior was evaluated for tylosin extraction from aqueous and milk samples. An off‐line SPE‐UV method was applied. An acceptable linearity was obtained in the range of 1–20 μg ml−1 and the average recovery at three spike levels in milk samples was higher than 92%. The limit of quantification was 2.6 × 10−2 μg ml−1. The manufactured SPE cartridge has a great potential for clean‐up processes in complex media. The cartridge offers a fast and sensitive option to the existing sorbents for extracting this drug from milk samples.
Curing behavior of a UV‐curable inkjet ink: Distinction between surface‐cure and deep‐cure performance
Authors: Simon Jonas , Langenscheidt Andreas 
Published: March 2020

AbstractSafety requirements and the need of low‐migration UV inks have received increasing attention in the packaging industry. Crucial for the development and design of low‐migration UV inkjet inks for migration‐sensitive applications is the polymerization degree. In this study, curing‐behavior of a black, high purity packaging ink (HPP‐ink) was monitored using ATR‐FTIR spectroscopy. UV irradiation of HPP‐ink led to changes in specific absorption bands of the FTIR spectra due to crosslinking reaction of double bonds. Changes in absorptions bands at 1,408 and 1,321 cm−1 permitted the determination of CC conversion of acrylic and vinyl double bond, independently of one another. In addition, a method was developed which allows the investigation of surface‐cure and deep‐cure behavior, separately.
Using viscoelastic modeling and molecular dynamics based simulations to characterize polymer natural fiber composites
Authors: Prasad Krishnamurthy , Nikzad Mostafa , Sbarski Igor 
Published: March 2020

AbstractThe potential for polymer natural fiber composites for manufacturing storage units for products with high ethanol content is explored. The influence of ethanol diffusion into the microstructure of the storage unit on its long‐term mechanical (specifically creep compliance) and viscoelastic properties are measured. Burger's model for polymer viscoelasticity is used to predict durability and other fundamental properties of the composite based on the creep compliance trends. Properties such as the Maxwell moduli and Maxwell viscosities are then modeled as a function of net ethanol uptake and the concentration of natural fiber dispersed phase. Later, a combination of classical molecular dynamics (MD) and semi empirical modeling is used to predict the trends in ethanol diffusion coefficient as a function of temperature and natural fiber concentration. The most efficacious models for this purpose and the ways and means of further improving the simulation accuracy are discussed.