bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shear Stress–Induced miR-143-3p in Collateral Arteries Contributes to Outward Vessel Growth by Targeting Collagen V-α2
Authors: Troidl Kerstin , Hammerschick Thomas , Albarran-Juarez Julian , Jung Georg , Schierling Wilma , Tonack Sarah , Krüger Marcus , Matuschke Benjamin , Troidl Christian , Schaper Wolfgang , Schmitz-Rixen Thomas , Preissner Klaus T. , Fischer Silvia 
Published: March 2020

Objective:
Arteriogenesis, describing the process of collateral artery growth, is activated by fluid shear stress (FSS). Since this vascular mechanotransduction may involve microRNAs (miRNAs), we investigated the FSS-induced expression of vascular cell miRNAs and their functional impact on collateral artery growth during arteriogenesis.

Approach and Results:
To this end, rats underwent femoral artery ligation and arteriovenous anastomosis to increase collateral blood flow to maximize FSS and trigger collateral vessel remodeling. Five days after surgery, a miRNA expression profile was obtained from collateral tissue, and upregulation of 4 miRNAs (miR-24-3p, miR-143-3p, miR-146a-5p, and miR-195-5p) was verified by quantitative polymerase chain reaction. Knockdown of miRNAs at the same time of the surgery in an in vivo mouse ligation and recovery model demonstrated that inhibition of miR-143-3p only severely impaired blood flow recovery due to decreased arteriogenesis. In situ hybridization revealed distinct localization of miR-143-3p in the vessel wall of growing collateral arteries predominantly in smooth muscle cells. To investigate the mechanotransduction of FSS leading to the increased miR-143-3p expression, cultured endothelial cells were exposed to FSS. This provoked the expression and release of TGF-β (transforming growth factor-β), which increased the expression of miR-143-3p in smooth muscle cells in the presence of SRF (serum response factor) and myocardin. COL5A2 (collagen type V-α2)—a target gene of miR-143-3p predicted by in silico analysis—was found to be downregulated in growing collaterals.

Conclusions:
These results indicate that the increased miR-143-3p expression in response to FSS might contribute to the reorganization of the extracellular matrix, which is important for vascular remodeling processes, by inhibiting collagen V-α2 biosynthesis.
Accurate Conduction Velocity Maps and Their Association With Scar Distribution on Magnetic Resonance Imaging in Patients With Postinfarction Ventricular Tachycardias
Authors: Aronis Konstantinos N. , Ali Rheeda L. , Prakosa Adityo , Ashikaga Hiroshi , Berger Ronald D. , Hakim Joe B. , Liang Jialiu , Tandri Harikrishna , Teng Fei , Chrispin Jonathan , Trayanova Natalia A. 
Published: March 2020

Background:
Characterizing myocardial conduction velocity (CV) in patients with ischemic cardiomyopathy (ICM) and ventricular tachycardia (VT) is important for understanding the patient-specific proarrhythmic substrate of VTs and therapeutic planning. The objective of this study is to accurately assess the relation between CV and myocardial fibrosis density on late gadolinium–enhanced cardiac magnetic resonance imaging (LGE-CMR) in patients with ICM.

Methods:
We enrolled 6 patients with ICM undergoing VT ablation and 5 with structurally normal left ventricles (controls) undergoing premature ventricular contraction or VT ablation. All patients underwent LGE-CMR and electroanatomic mapping (EAM) in sinus rhythm (2960 electroanatomic mapping points analyzed). We estimated CV from electroanatomic mapping local activation time using the triangulation method that provides an accurate estimate of CV as it accounts for the direction of wavefront propagation. We evaluated the association between LGE-CMR intensity and CV with multilevel linear mixed models.

Results:
Median CV in patients with ICM and controls was 0.41 m/s and 0.65 m/s, respectively. In patients with ICM, CV in areas with no visible fibrosis was 0.81 m/s (95% CI, 0.59–1.12 m/s). For each 25% increase in normalized LGE intensity, CV decreased by 1.34-fold (95% CI, 1.25–1.43). Dense scar areas have, on average, 1.97- to 2.66-fold slower CV compared with areas without dense scar. Ablation lesions that terminated VTs were localized in areas of slow conduction on CV maps.

Conclusions:
CV is inversely associated with LGE-CMR fibrosis density in patients with ICM. Noninvasive derivation of CV maps from LGE-CMR is feasible. Integration of noninvasive CV maps with electroanatomic mapping during substrate mapping has the potential to improve procedural planning and outcomes.

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Brain Atrophy and the Risk of Futile Endovascular Reperfusion in Acute Ischemic Stroke
Authors: Pedraza María I. , de Lera Mercedes , Bos Daniel , Calleja Ana I. , Cortijo Elisa , Gómez-Vicente Beatriz , Reyes Javier , Coco-Martín María Begoña , Calonge Teodoro , Agulla Jesús , Martínez-Pías Enrique , Talavera Blanca , Pérez-Fernández Santiago , Schüller Miguel , Galván Jorge , Castaño Miguel , Martínez-Galdámez Mario , Arenillas Juan F. 
Published: March 2020

Background and Purpose—
We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.

Methods—
We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.

Results—

From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004],
P
<0.001) and between global cortical atrophy score and age (odds ratio, 1.001 [95% CI, 1.001–1.002],
P
<0.001) in determining the risk of futile reperfusion.

Conclusions—
A higher degree of cortical and subcortical brain atrophy is associated with futile endovascular reperfusion in anterior circulation acute ischemic stroke. The impact of brain atrophy on insufficient clinical recovery after endovascular reperfusion appears to be independently amplified by age and by infarct volume.
Abundance and size of European lobsters (Homarus gammarus) and brown crabs (Cancer pagurus) inside and outside the Kåvra lobster reserve (west coast of Sweden)
Authors: Øresland Vidar , Oxby Gert , Oxby Fredrik 
Published: March 2020

Abstract
The common method of using lobster-pot catch data for investigating relative abundance, sex and size distribution has serious disadvantages. This study estimates relative abundance and size of the European lobster Homarus gammarus and the brown crab Cancer pagurus using scuba diving techniques. The study areas were the Kåvra lobster reserve (Kåvra) on the Swedish west coast and three very different nearby areas where fishing for crustaceans is allowed: Gullmarsfjorden; the archipelago; and the offshore area. A total of 167 lobsters and 337 brown crabs were observed during 33 scuba dives (each 30 minutes long) in 2018-2019. The estimated mean abundance of lobsters was three to fifteen times as high at Kåvra in comparison with the other three areas (all exact showing that the statistical populations were distinct in comparison with Kåvra; Wilcoxon-Mann-Whitney Test). Dive sites in the outer part of the offshore area had the lowest abundance of lobsters although they had seemingly good lobster habitats and low fishing intensity. Large lobsters with a carapace length of ⩾15 cm were found only at Kåvra where they made up 24% of the lobsters. The proportion of large lobsters inside Kåvra continues to increase after 30 years of protection. Together, this emphasizes the impact of fishing on lobster abundance and size distribution, and indicates that limited recruitment and migration might possibly affect offshore lobster “sub populations”. Kåvra was the only area where the abundance of lobsters exceeded the abundance of brown crabs (). However, the abundance of brown crabs at Kåvra was as low as in Gullmarsfjorden () where fishing for crabs is allowed. Possible complex lobster/brown crab interactions together with other factors that might explain the low abundance of the protected brown crab at Kåvra, need to be investigated further.
Increased Drought Risk in South Asia under Warming Climate: Implications of Uncertainty in Potential Evapotranspiration Estimates
Authors: Aadhar Saran , Mishra Vimal 
Published: March 2020

AbstractObserved and projected changes in potential evapotranspiration (PET) and drought are not well constrained in South Asia. Using five PET estimates [Thornthwaite (PET-TH), Hargreaves–Samani (PET-HS), Penman–Monteith (PET-PM), modified Penman–Monteith (PET-MPM), and energy (PET-EN)] for the observed (1979–2018, from ERA5) and future warming climate, we show that significant warming has occurred in South Asia during 1979–2018. PET changes show considerable uncertainty depending on the method used. For instance, PET-TH has increased significantly while all the other four methods show a decline in PET in the majority of South Asia during the observed period of 1979–2018. The increase in PET-TH is substantially higher than PET-HS, PET-PM, and PET-MPM due to a higher (3–4 times) sensitivity of PET-TH to warming during the observed period. Under the 1.5°, 2.0°, and 2.5°C warming worlds, global climate models from phase 5 of the Coupled Model Intercomparison Project (CMIP5 GCMs) project increases in PET and drought frequency over the majority of the regions. Drought estimates based on PET-EN and PET-MPM are consistent with soil moisture–based drought estimates and project a substantial increase in the frequency of severe droughts under warming climate in South Asia. In addition, the projected frequency of severe drought based on PET-TH, which is an outlier, is about 5 times higher than PET-EN and PET-MPM. Methods to estimate PET contribute the most in the overall uncertainty of PET and drought projections in South Asia, primarily due to PET-TH. Drought estimates based on PET-TH are not reliable for the observed and projected future climate. Therefore, future drought projections should be either based on PET-EN/PET-MPM or soil moisture.
Surface Expression of a Wall Fountain: Application to Subglacial Discharge Plumes
Authors: McConnochie Craig D. , Cenedese Claudia , McElwaine Jim N. 
Published: March 2020

AbstractWe use laboratory experiments and theoretical modeling to investigate the surface expression of a subglacial discharge plume, as occurs at many fjords around Greenland. The experiments consider a fountain that is released vertically into a homogeneous fluid, adjacent either to a vertical or a sloping wall, that then spreads horizontally at the free surface before sinking back to the bottom. We present a model that separates the fountain into two separate regions: a vertical fountain and a horizontal, negatively buoyant jet. The model is compared to laboratory experiments that are conducted over a range of volume fluxes, density differences, and ambient fluid depths. It is shown that the nondimensionalized length, width, and aspect ratio of the surface expression are dependent on the Froude number, calculated at the start of the negatively buoyant jet. The model is applied to observations of the surface expression from a Greenland subglacial discharge plume. In the case where the discharge plume reaches the surface with negative buoyancy the model can be used to estimate the discharge properties at the base of the glacier.
Gastrointestinal vasculitis due to systemic lupus erythematosus treated with rituximab: a case report
Authors: Kenar Gökçe , Atay Kadri , Yüksek Gül Emek , Öz Burak , Koca Süleyman Serdar 
Published: March 2020

Background Patients with systemic lupus erythematosus may present with variable gastrointestinal manifestations including peritonitis, pancreatitis, enteritis, and vasculitis. Gastrointestinal vasculitis is one of the most devastating complications of systemic lupus erythematosus, with a mortality rate of 50% when it progresses to bowel ischemia and is complicated by hemorrhage or perforation. Case report A young female patient known to have systemic lupus erythematosus, lupus nephritis, and antiphospholipid antibody syndrome, on immunosuppressive treatment presented to the emergency department with acute abdominal pain and nausea. The clinical findings were first associated with an acute flare of lupus nephritis according to the assessments with active laboratory parameters. However, over a short time the abdominal pain worsened and was accompanied by peritonitis and gastrointestinal hemorrhage. The computed tomography scans demonstrated a dilated bowel and thickening of the bowel compatible with gastrointestinal vasculitis. The upper and lower gastrointestinal endoscopy supported the diagnosis of vasculitis by showing multiple ulcerative lesions along the gastrointestinal tract. The patient was successfully treated with pulse corticosteroids urgently, with a fast response to subsequent rituximab therapy without any relapses. Treatment with cyclophosphamide was not preferred because the patient had a high cumulative dose. Conclusion Gastrointestinal vasculitis should be a primary differential diagnosis in patients with systemic lupus erythematosus presenting with abdominal pain because of its rapid progression and high mortality. The treatment choice has been suggested as cyclophosphamide for severe cases in the literature. In this case report, a patient successfully treated with rituximab without any relapses was documented.
Relationship between remission, disease activity and patient-reported outcome measures in patients with recent-onset systemic lupus erythematosus
Authors: Heijke Rebecca , Björk Mathilda , Frodlund Martina , McDonald Laura , Alemao Evo , Sjöwall Christopher 
Published: March 2020

Objective Definitions of remission in systemic lupus erythematosus (SLE; DORIS (1A/1B/2A/2B)), disease activity assessments and patient-reported outcome measures (PROMs) are useful in shared decision making between patients with SLE and physicians. We used longitudinal registry data from well-characterized Swedish patients with recent-onset SLE to explore potential correlations between DORIS status or disease activity, and PROMs. Methods Patients from the Clinical Lupus Register in North-Eastern Gothia, Sweden, who fulfilled the 1982 American College of Rheumatology and/or the 2012 Systemic Lupus International Collaborating Clinics classification criteria without prior organ damage, were enrolled at diagnosis. Data on treatments, serology, remission status (DORIS), disease activity (SLE Disease Activity Index-2000 (SLEDAI-2K)) and PROMs (quality of life: EuroQoL-5 Dimensions (EQ-5D); pain intensity, fatigue and well-being: visual analog scale (VAS) 0–100 mm) were collected during rheumatology clinic visits at months 0 (diagnosis), 6, 12, 24, 36, 48 and 60. Correlations were assessed using Pearson correlation and/or beta regression coefficients. Results A total of 41 patients were enrolled (median age = 39 years, 80% female, 85% white). Achievement of DORIS 1A and 2A (neither of which includes serology) significantly correlated with all PROMs (EQ-5D: p ≤ 0.02; pain: p = 0.0001; fatigue: p = 0.0051; well-being: p < 0.0001). Disease activity measures were correlated with VAS pain intensity ( p < 0.03) and VAS well-being ( p < 0.04). Conclusions Our findings illustrate the importance of the interplay between remission, disease activity assessments and PROMs. PROMs may be a useful tool in clinical practice, being administered prior to patient visits to streamline clinical care.
Is Energy Delivery Guided by Indirect Calorimetry Associated With Improved Clinical Outcomes in Critically Ill Patients? A Systematic Review and Meta-analysis
Authors: Tatucu-Babet Oana A , Fetterplace Kate , Lambell Kate , Miller Eliza , Deane Adam M , Ridley Emma J 
Published: March 2020

Background: Indirect calorimetry (IC) is recommended to guide energy delivery over predictive equations in critical illness due to its precision. However, the impact of using IC to measure energy expenditure on clinical outcomes is uncertain. Objective: To evaluate whether using IC to measure energy expenditure to inform energy delivery reduced hospital mortality and improved other important outcomes compared to using predictive equations in critically ill adults. Methods: A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline. Medline, Embase, CINAHL, and the Cochrane Library were searched for studies using IC to guide energy delivery compared to a predictive equation in adult critically ill patients with the primary outcome (hospital mortality) or any of the secondary outcomes reported (including but not limited to hospital and intensive care unit (ICU) length of stay (LOS) and duration mechanical ventilation (MV). Risk of bias within studies was assessed using the Cochrane “Risk of Bias” 1 tool. Random-effect meta-analyses were used when heterogeneity between studies existed (I2 > 50%). Data are reported as median (interquartile range [IQR]), binomial outcomes as odds ratio (OR), 95% confidence interval (CI), and continuous outcomes as mean difference (MD). Results: Of 4060 articles, 4 randomized controlled trials were identified with 396 patients included in analysis. Three studies were considered low risk of bias and 1 as high risk. Two studies reported hospital mortality (n = 130 and 40 participants, respectively). When combined, no association between IC-guided energy delivery and hospital mortality was found (OR = 0.81, 95% CI = [0.25, 2.67], P = 0.73, I2 = 52). No differences were reported with ICU mortality and hospital LOS between groups, but ICU LOS and duration of MV varied across all studies. According to the meta-analysis, no differences were observed in ICU LOS (MD = 1.39, 95% CI = [–5.01, 7.79], P = 0.67, I2 = 81%), although the duration of MV was increased when energy delivery was guided by IC (MD = 2.01, 95% CI = [0.45, 3.57], P = 0.01, I2 = 26%). In all 4 studies, prescribed energy targets were more closely met when energy delivery was informed by IC compared to a predictive equation. Three studies reported the percentage delivered versus the prescribed energy target, with the median (IQR) delta between the IC and predictive equation arms 19% (10%-32%). Conclusion: Limited data exist to assess the impact of using IC to inform energy delivery in comparison to predictive equations on hospital mortality. The association of IC use with other important outcomes, including duration of MV, needs to be further explored before definitive conclusions can be made.
Searching for contact with birth relatives: Search angels and search facilitators
Authors: Baden Amanda L , Harrington Elliotte Sue , White Ebony 
Published: March 2020

Summary Reunification or post-adoption contact between adoptees, birth families, and other adoption stakeholders has become a normalized developmental trajectory, yet the process of seeking contact after adoption placement varies greatly depending on numerous factors including access to original birth certificates, openness of the adoption, and systemic and institutional challenges that may aid or hinder contact. In this study, 101 post-adoption search facilitators responded to an online survey comprised of scale items and open-ended responses. Findings Respondents reported that most had no formal education or training to prepare them to assist with searches, they were primarily self-taught and utilized workshops and conferences as a secondary source of preparation, and only about one-quarter required counseling as part of the search process. Findings also indicated that formal education was rated as not helpful and office training (for those who had it) as neutral in its helpfulness. The primary theme identified in the data was that search facilitators must recognize emotions, particularly the grief and loss, associated with the search process to be effective. Applications Social work educators can prepare social work practitioners to effectively assist with post-adoption searches and reunions for adoptees and first/birth parents. Best practice will include training social workers to anticipate both the logistical and emotional needs of searchers.
Why Do People Trust Their State Government?
Authors: Wolak Jennifer 
Published: March 2020

AbstractAre the origins of trust in state government different from the reasons why people trust the national government? I argue that trust in state government has distinctive origins, tied to differences in how states operate within a federal system of government. Leveraging variations in the character of the states, I consider whether trust in state government is a function of its proximity to citizens, people's relative preferences for smaller government, and the homogeneity of state electorates. Using responses to the 2017 Cooperative Congressional Election Study, I show feelings of trust in state government follow not only from state political conditions and economic performance but also from the distinctive character of the states. These findings challenge prior accounts that argue that diffuse trust in state government reflects only how people feel about the national government, and highlight how large states and small states face different challenges in cultivating trust in state government.