bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defense Response in Brazilian Honey Bees (Apis mellifera scutellata × spp.) Is Underpinned by Complex Patterns of Admixture
Authors: Harpur Brock A , Kadri Samir M , Orsi Ricardo O , Whitfield Charles W , Zayed Amro 
Published: June 2020

AbstractIn 1957, an invasive and highly defensive honey bee began to spread across Brazil. In the previous year, Brazilian researchers hoped to produce a subtropical-adapted honey bee by crossing local commercial honey bees (of European origin) with a South African honey bee subspecies (Apis mellifera scutellata; an A-lineage honey bee subspecies). The resulting cross—African hybrid honey bees (AHBs)—escaped from their enclosure and spread through the Americas. Today, AHB is the most common honey bee from Northern Argentina to the Southern United States. AHBs are much more likely to sting nest intruders than managed European-derived honey bee colonies. Previous studies have explored how genetic variation contributes to differences in defense response between European-derived honey bee and AHB. Although this work demonstrated very strong genetic effects on defense response, they have yet to pinpoint which genes influence variation in defense response within AHBs, specifically. We quantified defense response for 116 colonies in Brazil and performed pooled sequencing on the most phenotypically divergent samples. We identified 65 loci containing 322 genes that were significantly associated with defense response. Loci were strongly associated with metabolic function, consistent with previous functional genomic analyses of this phenotype. Additionally, defense-associated loci had nonrandom and unexpected patterns of admixture. Defense response was not simply the product of more A-lineage honey bee ancestry as previously assumed, but rather an interaction between A-lineage and European alleles. Our results suggest that a combination of A-lineage and European alleles play roles in defensive behavior in AHBs.
Diverse plant mixtures sustain a greater arbuscular mycorrhizal fungi spore viability than monocultures after 12 years
Authors: Dietrich Peter , Roscher Christiane , Clark Adam Thomas , Eisenhauer Nico , Schmid Bernhard , Wagg Cameron 
Published: June 2020

Abstract

Aims
Intensive land management practices can compromise soil biodiversity, thus jeopardizing long-term soil productivity. Arbuscular mycorrhizal fungi (AMF) play a pivotal role in promoting soil productivity through obligate symbiotic associations with plants. However, it is not clear how properties of plant communities, especially species richness and composition influence the viability of AMF populations in soils.

Methods
Here we test whether monocultures of eight plant species from different plant functional groups, or a diverse mixture of plant species, maintain more viable AMF propagules. To address this question, we extracted AMF spores from 12-year old plant monocultures and mixtures and paired single AMF spores with single plants in a factorial design crossing AMF spore origin with plant species identity.

Important Findings
AMF spores from diverse plant mixtures were more successful at colonizing multiple plant species and plant individuals than AMF spores from plant monocultures. Furthermore, we found evidence that AMF spores originating from diverse mixtures more strongly increased biomass than AMF from monocultures in the legume Trifolium repens L. AMF viability and ability to interact with many plant species were greater when AMF spores originated from 12-year old mixtures than monocultures. Our results show for the first time that diverse plant communities can sustain AMF viability in soils and demonstrate the potential of diverse plant communities to maintain viable AMF propagules that are a key component to soil health and productivity.
Attitude and Information from Health Professionals Were Associated with Decision to Donate Organs among Arabic-Speaking Refugees: Exploring Opportunities for Intervention
Authors: Maneze Della , Ramjan Lucie , Rowhani-Farid Naysan , Kovai Vilas , Gadalla Amin , Barham Yousef , Salamonson Yenna 
Published: June 2020

Abstract
This cross-sectional survey study conducted between May and August 2017 on Arabic-speaking refugees resettled in Australia examined factors associated with willingness to donate organs. Of the 239 respondents, those who expressed greater willingness to donate organs and tissues were more likely to: (a) be Christians; (b) have obtained information from healthcare professionals (HCPs); (c) have higher organ and tissue donation (OTD) knowledge; (d) have a positive attitude towards OTD; and (e) have high English language acculturation levels. Nevertheless, after controlling for English language usage and religion, having a positive attitude towards OTD and receiving information from HCPs emerged as independent predictors of willingness to donate, underscoring the importance of educational interventions by HCPs
Forecasting seeing for the Maunakea Observatories
Authors: Lyman Ryan , Cherubini Tiziana , Businger Steven 
Published: June 2020

ABSTRACT
Optical turbulence greatly impacts the range and quality of astronomical observations. Advanced knowledge of the expected atmospheric optical turbulence provides important guidance that helps astronomers decide which instrument to schedule and enables them to optimize the adaptive optics technology that improves image resolution. Along with forecasts of weather conditions, prediction of the optical observing quality on the Maunakea summit has been a goal for the Maunakea Weather Center (MKWC) since its inception more than 20 yr ago. Forecasting optical turbulence, and its derivative, ‘seeing’, has proven to be quite challenging because optical turbulence is too small and complex to directly capture with a regional weather model. Fortunately, the permanent installation of a Differential Image Motion Monitor (DIMM) and Multi-Aperture Scintillation Sensor (MASS) at the summit of Maunakea has made seeing observations available during the last decade, providing valuable feedback to the MKWC. This paper summarizes the experience at MKWC in anticipating optical turbulence for the summit of Maunakea accrued through years of daily operational forecasting, and continuous comparison between MKWC official forecasts, model guidance, and observational measures of seeing. Access to a decade seeing observations has allowed quantification the factors that impact seeing, including wind shear, atmospheric stability patterns, and optical turbulence, and to document the seasonal and intra-seasonal variations in seeing. Consequently, the combination of experience gained, and custom model guidance has led to more accurate seeing forecasts (rms errors averaging &lt;0.25 arcsec since 2012) for the Maunakea astronomical observatories.
Blind deconvolution in astronomy with adaptive optics: the parametric marginal approach
Authors: Fétick R J-L , Mugnier L M , Fusco T , Neichel B 
Published: June 2020

ABSTRACT
One of the major limitations of using adaptive optics (AO) to correct image post-processing is the lack of knowledge about the system’s point spread function (PSF). The PSF is not always available as direct imaging on isolated point-like objects, such as stars. The use of AO telemetry to predict the PSF also suffers from serious limitations and requires complex and yet not fully operational algorithms. A very attractive solution is to estimate the PSF directly from the scientific images themselves, using blind or myopic post-processing approaches. We demonstrate that such approaches suffer from severe limitations when a joint restitution of object and PSF parameters is performed. As an alternative, here we propose a marginalized PSF identification that overcomes this limitation. In this case, the PSF is used for image post-processing. Here we focus on deconvolution, a post-processing technique to restore the object, given the image and the PSF. We show that the PSF estimated by marginalization provides good-quality deconvolution. The full process of marginalized PSF estimation and deconvolution constitutes a successful blind deconvolution technique. It is tested on simulated data to measure its performance. It is also tested on experimental AO images of the asteroid 4-Vesta taken by the Spectro-Polarimetric High-contrast Exoplanet Research (SPHERE)/Zurich Imaging Polarimeter (Zimpol) on the Very Large Telescope to demonstrate application to on-sky data.
Validation of PSF models for HST and other space-based observations
Authors: Gillis Bryan R , Schrabback Tim , Marggraf Ole , Mandelbaum Rachel , Massey Richard , Rhodes Jason , Taylor Andy 
Published: June 2020

ABSTRACT
Forthcoming space-based observations will require high-quality point spread function (PSF) models for weak gravitational lensing measurements. One approach to generating these models is using a wavefront model based on the known telescope optics. We present an empirical framework for validating such models to confirm that they match the actual PSF to within requirements by comparing the models to the observed light distributions of isolated stars. We apply this framework to Tiny Tim, the standard tool for generating model PSFs for the Hubble Space Telescope (HST), testing its models against images taken by HST’s Advanced Camera for Surveys in the Wide Field Channel. We show that Tiny Tim’s models, in the default configuration, differ significantly from the observed PSFs, most notably in their sizes. We find that the quality of Tiny Tim PSFs can be improved through fitting the full set of Zernike polynomial coefficients that characterize the optics, to the point where the practical significance of the difference between model and observed PSFs is negligible for most use cases, resulting in additive and multiplicative biases both of order ∼4 × 10−4. We also show that most of this improvement can be retained through using an updated set of Zernike coefficients, which we provide.
The XMM Cluster Survey: new evidence for the 3.5-keV feature in clusters is inconsistent with a dark matter origin
Authors: Bhargava S , Giles P A , Romer A K , Jeltema T , Mayers J , Bermeo A , Hilton M , Wilkinson R , Vergara C , Collins C A , Manolopoulou M , Rooney P J , Rosborough S , Sabirli K , Stott J P , Swann E , Viana P T P 
Published: June 2020

ABSTRACT
There have been several reports of a detection of an unexplained excess of X-ray emission at $\simeq$3.5 keV in astrophysical systems. One interpretation of this excess is the decay of sterile neutrino dark matter. The most influential study to date analysed 73 clusters observed by the XMM–Newton satellite. We explore evidence for a ≃3.5-keV excess in the XMM-PN spectra of 117 redMaPPer galaxy clusters (0.1 &lt; z &lt; 0.6). In our analysis of individual spectra, we identify three systems with an excess of flux at $\simeq$3.5 keV. In one case (XCS J0003.3+0204), this excess may result from a discrete emission line. None of these systems are the most dark matter dominated in our sample. We group the remaining 114 clusters into four temperature (TX) bins to search for an increase in ≃3.5-keV flux excess with TX – a reliable tracer of halo mass. However, we do not find evidence of a significant excess in flux at ≃3.5 keV in any TX bins. To maximize sensitivity to a potentially weak dark matter decay feature at ≃3.5 keV, we jointly fit 114 clusters. Again, no significant excess is found at ≃3.5 keV. We estimate the upper limit of an undetected emission line at ≃3.5 keV to be 2.41 × 10−6 photons cm−2 s−1, corresponding to a mixing angle of sin 2(2θ) = 4.4 × 10−11, lower than previous estimates from cluster studies. We conclude that a flux excess at ≃3.5 keV is not a ubiquitous feature in clusters and therefore unlikely to originate from sterile neutrino dark matter decay.
Relationships Between Race, Gender, and Spot Urine Levels of Biomarkers of Tobacco Exposure Vary Based on How Creatinine Is Handled in Analyses
Authors: Carroll Dana M , Cigan Shannon , Ikuemonisan Joshua , Hammonds Taylor , Stepanov Irina , St. Helen Gideon , Benowitz Neal , Hatsukami Dorothy K 
Published: June 2020

Abstract

Introduction
We illustrate the differential impact of common analysis approaches to handling urinary creatinine, a measure for urine dilution, on relationships between race, gender, and biomarkers of exposure measured in spot urine.

Methods
In smokers, spot urine levels of total nicotine equivalents (TNE, sum of total nicotine, total cotinine, and total 3′-hydroxycotinine) and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) overall and per cigarette were examined. Relationships between race (African Americans [AA] n = 373, Whites n = 758) or gender (males n = 629, females n = 502) and TNE or NNAL were examined using the following approaches to handling creatinine: (1) unadjusted/unstandardized; (2) standardization; (3) adjustment as a covariate. Significance was considered at p &lt; .05

Results
Creatinine was higher in AA versus Whites (1.19 vs. 0.96 mg/mL; p &lt; .0001) and in males versus females (1.21 vs. 0.84 mg/mL; p &lt; .0001). Independent of how creatinine was handled, TNE was lower among AA than Whites (TNE ratios AA vs. Whites: 0.67–0.84; p’s &lt; .05). Unadjusted TNE per cigarette was higher among AA versus Whites (ratio 1.12; p = .0411); however, the relationship flipped with standardization (ratio 0.90; p = .0360) and adjustment (ratio 0.95; p = .3165). Regarding gender, unadjusted TNE was higher among males versus females (ratio 1.13; p = .0063), but the relationship flipped with standardization (ratio 0.79; p &lt; .0001) or adjustment (ratio 0.89; p = .0018). Unadjusted TNE per cigarette did not differ across gender (ratio 0.98; p = .6591), but lower levels were found in males versus females with standardization (ratio 0.68; p &lt; .0001) and adjustment (ratio 0.74; p &lt; .0001). NNAL displayed similar patterns.

Conclusions
Relationships between race, gender, and spot urine levels of biomarkers of exposure can vary greatly based on how creatinine is handled in analyses.

Implications
Lack of appropriate methods can lead to discrepancies across reports on variability of urinary biomarkers by race and gender. We recommend that for any analyses of biomarkers of exposure measure in spot urine samples across race, gender, or other population subgroups that differ in urinary creatinine levels, sensitivity analyses comparing the different methods for handling urinary creatinine should be conducted. If methods result in discrepant findings, this should be clearly noted and discussed.
Optimal Treatment Duration of Pseudomonas aeruginosa Infections in Allogeneic Hematopoietic Cell Transplant Recipients
Authors: Olearo Flaminia , Kronig Ilona , Masouridi-Levrat Stavroula , Chalandon Yves , Khanna Nina , Passweg Jakob , Medinger Michael , Mueller Nicolas J , Schanz Urs , Van Delden Christian , Neofytos Dionysios 
Published: June 2020

Abstract
In a large, multicenter, contemporary, 8-year, cohort study, one third of allogeneic-hematopoietic cell transplant (HCT) recipients with Pseudomonas aeruginosa (PSA) infection developed a recurrent infection within 3 months. Antibiotic treatment duration of ≥14 days was the only significantly associated variable with reduced recurrence rates of PSA infections in allogeneic-HCT recipients.
A Randomized Comparative Trial of Targeted Steroid Injection via Epidural Catheter vs Standard Transforaminal Epidural Injection for the Treatment of Unilateral Cervical Radicular Pain: Six-Month Results
Authors: McCormick Zachary L , Conger Aaron , Sperry Beau P , Teramoto Masaru , Petersen Russell , Salazar Fabio , Cunningham Shellie , Michael Henrie A , Bisson Erica , Kendall Richard 
Published: June 2020

Abstract

Objectives
Compare the effectiveness of catheter-directed cervical interlaminar epidural steroid injection (C-CIESI) with triamcinolone to cervical transforaminal steroid injection (CTFESI) with dexamethasone for the treatment of refractory unilateral radicular pain.

Design
Prospective, randomized, comparative trial.

Methods
Primary outcome: proportion of participants with ≥50% numeric rating scale pain score reduction from baseline “dominant pain” (the greater of arm vs neck) at one month postinjection. Secondary outcomes: ≥30% Neck Disability Index (NDI-5) reduction and Patient Global Impression of Change (PGIC) response indicating “much improved” or “very much improved.”

Results
One hundred twenty participants (55.6% females, 52.3 ± 12.5 years of age, BMI 28.2 ± 6.5 kg/m2), were enrolled. The proportions of participants who experienced ≥50% pain reduction at one, three, and six months were 68.5% (95% CI = 54.9–79.5%), 59.3% (95% CI = 45.7–71.6%), and 60.8% (95% CI = 46.7–73.2%), respectively, in the C-CIESI group compared with 49.1% (95% CI = 36.4–62.0%), 46.4% (95% CI = 33.8–59.6%), and 51.9% (95% CI = 38.4–65.2%), respectively, in the CTFESI group. The between-group difference at one month was significant (P = 0.038). The proportions of participants who experienced a ≥30% NDI-5 score improvement were 64.0% (95% CI = 49.8–76.1%) and 54.9% (95% CI = 41.1–68.0%) in the C-CIESI and CTFESI groups (P = 0.352). Participants reported similar PGIC improvement in both groups: At six months, 53.2% (95% CI 38.9–67.1%) and 54.5% (95% CI = 39.7–68.7%) of the C-CIESI and CTFESI groups reported being “much improved” or “very much improved,” respectively (P = 0.897).

Conclusions
Both C-CIESI with triamcinolone and CTFESI with dexamethasone are effective in reducing pain and disability associated with refractory unilateral cervical radiculopathy in a substantial proportion of participants for at least six months.
Accurate Determination of the Cold Detection Threshold with High-Speed Cooling of the Skin
Authors: Lithfous Segolene , Després Olivier , Pebayle Thierry , Casadio Claudia , Dufour Andre 
Published: June 2020

AbstractObjectiveThis study used high-speed cooling of the skin and exact control of stimulus duration to measure the cold detection threshold in healthy participants. The objective was to compare the method of limits, in which the temperature is slowly and gradually increased/decreased until the subject perceives the stimulation, and the method of levels, in which the subject must detect brief thermal stimulations close to the threshold of perception.MethodsTwenty healthy volunteers (nine women, 11 men) aged 20–30 years participated in the study. The method of limits and method of levels were performed in all subjects in a counterbalanced order. Four cold detection thresholds were measured with the method of levels, with a temperature ramp of 300°C/sec and stimulus durations of 50 ms, 100 ms, 300 ms, and 500 ms. Three thresholds were measured with the method of limits, with temperature ramps of 1°C/sec, 2°C/sec, and 4°C/sec.ResultsOn average, the cold detection thresholds were −0.47°C below skin temperature with the method of levels and −1.67°C the method of limits. Interindividual variability was significantly lower with the method of levels than with the method of limits.ConclusionsThese results suggest that the method of levels is more accurate than the method of limits for measuring cold detection threshold. The improvement of cold detection threshold measurement may provide new perspectives to more precisely assess the function of A-delta fibers and the spino-thalamic pathway.
Frontline Innovation in Times of Crisis: Learning from the Corona Virus Pandemic
Authors: Hartmann Mia R K , Hartmann Rasmus Koss 
Published: June 2020

AbstractThe current COVID-19 pandemic brings about dramatic challenges for frontline police officers and their organizations. This will, we argue, likely have two implications for frontline learning and innovation. First, the pandemic will surely occasion a surge of frontline improvisation and innovation in police organizations responding to the crisis as the experienced needs for new solutions dramatically increase. Secondly, but equally importantly, this wave of frontline innovation is likely to be more transparent than is typically the case for innovations developed in frontline police work, because of changes in formal mandates and informal tolerance for procedural deviance. At this moment of unusually widespread and transparent frontline innovation, we propose an approach to capturing and diffusing this frontline innovation. By taking seriously the unique dynamics of frontline innovation, such an approach is likely to capture valuable innovations that might otherwise rapidly dissipate and be lost.
NICE public health guidance update
Authors: Ali Fizzah , Gabbay Mark , Baillie Nick 
Published: June 2020

AbstractThis article highlights recent guidance from the National Institute for Health and Care Excellence (NICE). It highlights the organization’s response to the COVID-19 pandemic and then provides a spotlight on workplace health in the context of long-term sickness absence and capability to work. It discusses some of the actions that need to be taken by a range of stakeholders in order to implement NICE guidance in this area and aid employees in ensuring good workplace health. The NICE guidance on workplace health, discussed in this article, predates the current pandemic. Comment is made specifically on fitness for work assessments, where the COVID-19 pandemic has posed a range of unique clinical challenges.
Prolonged persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals
Authors: Saurabh S , Kumar R , Gupta M K , Bhardwaj P , Nag V L , Garg M K , Misra S 
Published: June 2020

Summary

Background
Duration of persistence of SARS-CoV-2 in the upper respiratory tract of infected individuals has important clinical and epidemiological implications.

Aim
We aimed to establish the duration and risk factors for persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals.

Methods
Data of repeat rRT-PCR (real-time reverse transcription-polymerase chain reaction) test done for SARS-CoV-2 infected individuals at our institute at Jodhpur, India were analysed from 19 March to 21 May 2020. Duration of virus persistence was estimated with parametric regression models based on weibull, log-normal, log-logistic, gamma and generalized gamma distributions. Factors associated with prolonged viral persistence were analysed with the best-fitting model.

Results
Fifty-one SARS-CoV-2 infected individuals with repeat rRT-PCR test were identified with 44 asymptomatics. The asymptomatic individuals had median virus persistence duration of 8.87 days (95% CI: 7.65–10.27) and 95 percentile duration of 20.70 days (95% CI: 16.08–28.20). The overall median virus persistence including both symptomatic and asymptomatic individuals was found to be 9.18 days (95% CI: 8.04–10.48). Around one-fourth asymptomatics (10/44) demonstrated SARS-CoV-2 persistence beyond 2 weeks. Age &lt;60 years and local transmission were found to be significantly associated with longer virus persistence among asymptomatic individuals on univariate regression but not in multivariate analysis.

Conclusion
Recommended home isolation duration for SARS-CoV-2 infected individuals in India should be extended from 17 days to at least 3 weeks. Prolonged persistence of SARS-CoV-2 in a considerable proportion of asymptomatic individuals merits attention with regard to ensuring universal infection prevention precautions irrespective of symptomatic status.