bluuebunny/crossref_metadata_2025_split huggingface dataset:
First clinical experiences with an anatomical meniscus prosthesis
Authors: van Tienen Tony , Defoort Koen , Emans Pieter , van der Groes Sebastiaan , van der Zanden Maarten 
Published: September 2020

Introduction: Meniscus loss is a known cause for medial compartment joint pain related to knee osteoarthritis (KOA). The cartilage in knee joints of KOA patients degenerates over time, resulting in accumulative complaints and reduced quality of life. When the osteoarthritis progresses knee arthroplasty is often the eventual treatment once they have reached the eligible age. In case of low grade KOA and an absent meniscus, the orthopedic surgeon currently has no established surgical procedure at hand to restore the knee mechanics and provide pain relief. Methods: A durable medial meniscus prosthesis has been developed to overcome this treatment gap. This anatomically shaped polymer prosthesis is based on a decade of pre-clinical work at the Radboudumc. The Trammpolin meniscus prosthesis is currently being evaluated in a First in Human clinical trial in three orthopedic centers in the Netherlands. The first results and next steps will be shared in this presentation.
Clinical Effect of Open-wedge High Tibial Osteotomy in Treatment of Kellgren-lawrence IV Knee Osteoarthritis Associated with Varus Tibial Deformity
Authors: Sha Yu , Yan Lei 
Published: September 2020

Objectives: The purpose of this study is to evaluate the clinical efficacy of open-wedge high tibial osteotomy (HTO) in treatment of kellgren- lawrence IV anterior medial knee osteoarthritis with varus tibia. Methods: Between 2016 and 2018, 56 patients with kellgren -lawrence IV knee osteoarthritis associated with varus tibial deformity who underwent a medial open-wedge high tibial osteotomy at a tertiary hospital were prospectively followed up. The surgical effect and postoperative complications were observed and analyzed. Meanwhile, the hospital for special surgery (HSS) scores of knee function before operation and at the last follow-up after operation was compared. Results: The median follow up was 19.8 months (range, 18 to 24 months). At the last follow-up, there was 40 excellent cases, 14 good cases, 2 fair case and 0 poor case. There were no complications such as vascular and nerve injury, internal fixation fracture and infection. The HSS score of knee function (89.6±3.9) at the last follow-up after operation was higher than (63.2±6.4) points before operation, and the difference was statistically significant ( P ＜0.05). Conclusion: Medial opening high tibial osteotomy shows remarkable therapeutic effect for patients with knee osteoarthritis associated with varus tibial deformity, and it can effectively relief the pain of knee joint with less postoperative complications.
The application of Patient specific Instrument （PSI ）in total knee arthroplasty with valgus knee
Authors: Yuehui Wang , Shiping Zou , Liangliang Cao , Wenzhong Chen 
Published: September 2020

Introduction: To invest the auxiliary role of Patient specific Instrument(PSI) used as osteotomy guide plate in total knee arthroplasty(TKA) with valgus knee. Hypotheses: PSI osteotomy guide plate is applicable for total knee arthroplasty with valgus knee. Methods: A retrospective analysis was performed on 21 patients with valgus knee, including 5 males and 16 females, who underwent TKA in joint surgery department I of ZhengZhou Orthopaedic Hospital from March 2016 to February 2018. All the operations were performed with the assistance of PSI, and the radiographic and clinical evaluations including femoral tibial joint ectropion angle(FTA) before and after operation, range of motion(ROM) and the Hospital for Special Surgery (HSS) knee score were reviewed, and surgical complications were recorded. Results: All the 21 patients werefollowed up for 10 ˜ 26 months (mean 16 months).All the incisions healed by first intention. The FTA was reduced significantly to 6.3 °±1.2° after operation from 17.6 ° + 5.7 °(P < 0.05), the ROM was improved significantly from preoperative 71.3° ±5.8° to postoperative 102.4°±7.5° (P < 0.05), the HSS score at the last follow-up was improved from 38.2±5.7 to 87.5-3.5(P < 0.05). During the follow-up, no complications such as infection, loosening, sinking and valgus were observed. Conclusion: Providing accurate osteotomy, effective correction of the force line, simple operation and satisfactory clinical effect, the PSI osteotomy guide plate is applicable for total knee arthroplasty with valgus knee.
Clinical and functional outcomes of ACL reconstruction with tibial attachment preserving quadrupled hamstring graft
Authors: Dalal Shaival , Aminake Ghislain , Guro Randy , Chandratreya Amit , Kotwal Rahul 
Published: September 2020

Introduction: Recent literature supports the preservation of tibial attachment of hamstring grafts to enhance ‘‘ligamentization’’ process and prevent the potential problems of free graft such as pull-out or rupture in the early post-operative period. Another factor that has gained attention in recent days is graft diameter, which can be variable and is thought to be a factor contributing to graft failure in biomechanical and clinical studies. Numerous studies have shown conflicting evidence of graft diameter directly influencing the graft failure. Hypotheses: The aim of this study is to present our results of ACL reconstruction with preservation of the tibial attachment of the hamstring grafts along with loop-stitched quadrupled hamstring grafts fixed with Endobutton on the femoral side and an interference screw and staple on the tibial side. Methods: Prospective single-surgeon case-series evaluating patients undergoing surgery by this technique. Patients were followed up clinically and using PROMS from NLR with EQ-5D, KOOS, IKDC and Tegner scores. Paired two-tailed student t-tests were used to assess significance. Results: 45 patients had associated meniscal tear with 73.3 % undergoing repair. 3 cases (4.6 %) returned to theatre including, MUA for arthrofibrosis (n=1) and meniscal repair for recurrent medial meniscus tear (n=2). Incidence of graft re-rupture was seen in 1 patient. At a mean follow-up of 2.3 years, 80% (n=51) had complete peri-operative PROMS scores. Mean peri-operative EQ-5D VAS, EQ-5D Index, KOOS, IKDC and Tegner activity scores showed significant improvement (p<0.001). Multiple regression analysis does not find any correlation between PROMS and graft diameter. Conclusion: ACL reconstruction using tibial attachment preserving hamstring graft is a simple and , reproducible, and cost-effective technique that gives consistent clinical and functional outcomes, irrespective of the graft diameter . The natural tibial side insertion provides secure fixation and adds biology to the anatomic reconstruction, possibly reducing the re-rupture and failure rate.
A Qualitative Study of Health Care Providers’ Views on Integrating Oral Health into Prenatal Care
Authors: Adeniyi A. , Donnelly L. , Janssen P. , Jevitt C. , von Bergman H. , Brondani M. 
Published: September 2020

Objective: Providing preventive oral health during prenatal care is a recognized strategy for improving pregnant women’s access to oral health care. This study sought to qualitatively explore the views of health care providers in British Columbia (BC), Canada, on strategies for integrating preventive oral health into prenatal care. Methods: Twenty-four purposefully selected health care providers (13 oral health and 11 prenatal care providers) in Vancouver and Surrey BC participated in audio-recorded semistructured interviews. Interviews lasted from 31 to 61 min, were transcribed verbatim, and were analyzed using an inductive thematic analysis with N-Vivo software. Study validity was ensured via memoing, fieldnotes, member checking, and external audit. Results: Thematic analysis revealed 5 major themes: perception of integrated care, relevance of integrated prenatal oral health, strategies for achieving integrated prenatal oral health, drivers of the integration process, and barriers to integrating oral health during pregnancy. Interprofessional collaboration based on information sharing and communication was identified as a critical factor for integrated care. Oral health checks should be a component of prenatal assessments for achieving integrated prenatal oral health. Participants recommended that prenatal providers should offer oral health education and use screening questions to identify the pregnant woman’s oral health needs. The establishment of referral systems was advocated, while dental assessments and oral prophylaxis via the medical services plan were proposed. The inclusion of dental providers in prenatal teams and educating health care providers on interprofessional collaboration were also supported. Conclusion: Oral health and prenatal providers in BC are positively disposed to adopting integrated preventive prenatal oral health care based on interprofessional collaborative practices. The inclusion of oral health providers in prenatal teams was suggested. Knowledge Transfer Statement: The results of this study can be used by policymakers for advocacy and decision making when planning care delivery programs for women during pregnancy. Including the suggested strategies could lead to increased access to, and utilization of, oral health services among pregnant women.
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma
Authors: Ghione Paola , Faruque Promie , Mehta-Shah Neha , Seshan Venkatraman , Ozkaya Neval , Bhaskar Shakthi , Yeung James , Spinner Michael A. , Lunning Matthew , Inghirami Giorgio , Moskowitz Alison , Galasso Natasha , Ganesan Nivetha , van der Weyden Carrie , Ruan Jia , Prince H. Miles , Trotman Judith , Advani Ranjana , Dogan Ahmet , Horwitz Steven 
Published: September 2020

Abstract
Histone deacetylase inhibitors (HDACi) are active agents for peripheral T-cell lymphoma (PTCL). Anecdotally angioimmunoblastic T-cell lymphoma (AITL) appears to respond better than PTCL–not otherwise specified (NOS) to HDACi. The new World Health Organization classification shows that a subgroup of PTCL carries similarities in phenotype and gene expression profiling to AITL, comparable to T follicular helper (TFH) cells. The disease might behave similarly to AITL when treated with HDACi. We analyzed 127 patients with AITL or PTCL-NOS treated with HDACi at relapse as a single agent or in combination. We re-reviewed the pathology of all PTCL-NOS to identify the TFH phenotype. Patients received HDACi at relapse as a single agent in 97 cases (76%, 59 TFH, 38 non-TFH) or in combination in 30 cases (24%, 18 TFH, 12 non-TFH) including duvelisib, lenalidomide, lenalidomide plus carfilzomib, and pralatrexate. Seven PTCL-NOS had TFH phenotype; 2 PTCL-NOS were reclassified as AITL. Overall response rate (ORR) was 56.5% (28.9% complete response [CR]) in TFH and 29.4% (19.6% CR) in non-TFH phenotype patients (P = .0035), with TFH phenotype being an independent predictor of ORR (P = .009). Sixteen patients sufficiently responded to HDACi or HDACi in combination with another agent to proceed directly to allogeneic transplantation; 1 of 16 responded to donor lymphocyte infusion (12 TFH, 4 non-TFH). Our results, although retrospective, support that HDACi, as a single agent or in combination, may have superior activity in TFH-PTCL compared with non-TFH PTCL. This differential efficacy could help inform subtype-specific therapy and guide interpretation of HDACi trials.
Major adverse cardiovascular and limb events in patients with diabetes and concomitant peripheral artery disease treated with sodium glucose cotransporter 2 inhibitor versus dipeptidyl peptidase-4 inhibitor
Authors: Lee Hsin-Fu , Chen Shao-Wei , Liu Jia-Rou , Li Pei-Ru , Wu Lung-Sheng , Chang Shang-Hung , Yeh Yung-Hsin , Kuo Chi-Tai , Chan Yi-Hsin , See Lai-Chu 
Published: September 2020

Abstract
Background
Whether sodium glucose co-transporter 2 inhibitors (SGLT2i) are associated with a lower risk of cardiovascular as well as adverse lower limb events in patients with type-2 diabetes mellitus (T2DM) and concomitant peripheral artery disease (PAD) is unclear.
We aimed to evaluate the risk of cardiovascular and limb events, and death associated with the use of SGLT2i compared with dipeptidyl peptidase-4 inhibitors (DPP4i) among a longitudinal and national cohort of patients with T2DM.

Methods
In this nationwide retrospective cohort study based on the Taiwan National Health Insurance Research Database, we identified a total of 11,431 and 93,972 consecutive T2DM patients with PAD taking SGLT2i and DPP4i, respectively, from May 1, 2016, to December 31, 2017. We used 1:1 propensity score matching (PSM) to balance covariates across study groups. Patients were followed from the drug index date until the occurrence of clinical outcomes, death, discontinuation of the index drug, or the end of the study period, whichever occurred first.

Results
Overall, 56% and 44% of the patients were treated with dapagliflozin and empagliflozin, respectively. The use of SGLT2i had comparable risks of ischemic stroke and acute myocardial infarction, and was associated with lower risks of congestive heart failure (CHF) [hazard ratio (HR): 0.66; 95% confidence interval (CI) 0.49–0.89; p = 0.0062], lower limb ischemia requiring revascularization (HR: 0.73; 95% CI 0.54–0.98; p = 0.0367) or amputation (HR: 0.43; 95% CI 0.30–0.62; p < 0.0001), and cardiovascular death (HR: 0.67; 95% CI 0.49–0.90; p = 0.0089) when compared with the DDP4i group after PSM. The subgroup analysis revealed consistent results for CHF and major adverse limb outcomes for SGLT2i versus DPP4i among patients aged ≥ 75 years, the presence of chronic kidney disease and established cardiovascular disease was consistent with the main analysis.

Conclusions
SGLT2i were associated with lower risks of CHF and adverse lower limb events compared with DPP4i among patients with T2DM and PAD in real-world practice.
Early mechanical ventilation in patients with Guillain-Barré syndrome at high risk of respiratory failure: a randomized trial
Authors: Melone Marie-Anne , Heming Nicholas , Meng Paris , Mompoint Dominique , Aboab Jerôme , Clair Bernard , Salomon Jerôme , Sharshar Tarek , Orlikowski David , Chevret Sylvie , Annane Djillali 
Published: September 2020

Abstract
Introduction
About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumonia occurrence in GBS patients. We hypothesize that EMV will reduce the incidence of pneumonia.

Methods
This was a single centre, open-label, randomized controlled trial performed on two parallel groups. 50 intensive care unit adults admitted for Guillain-Barré syndrome and at risk for acute respiratory failure. Patients were randomized to early mechanical ventilation via face-mask or endotracheal intubation owing to the presence or absence of impaired swallowing (experimental arm), or to conventional care (control arm). The primary outcome was the incidence of pneumonia up to intensive care unit discharge (or 90 days, pending of which occurred first).

Findings
Twenty-five patients were randomized in each group. There was no significant difference between groups for the incidence of pneumonia (10/25 (40%) vs 9/25 (36%), P = 1). There was no significant difference between groups for the time to onset of pneumonia (P = 0.50, Gray test). During follow-up, there were 16/25 (64%) mechanically ventilated patients in the control group, and 25/25 (100%) in the experimental arm (P < 000·1). The time on ventilator was non-significantly shorter in the experimental arm (14 [7; 29] versus 21.5 [17.3; 35.5], P = 0.10). There were no significant differences between groups for length of hospital stay, neurological scores, the proportion of patients who needed tracheostomy, in-hospital death, or any serious adverse events.

Conclusions
In the present study including adults with Guillain-Barré syndrome at high risk of respiratory failure, we did not observe a prevention of pneumonia with early mechanical ventilation. Trial registration: ClinicalTrials.gov under the number NCT00167622. Registered 9 September 2005, https://clinicaltrials.gov/ct2/show/NCT00167622?cond=Guillain-Barre+Syndrome&cntry=FR&draw=2&rank=1
Deep learning-based estimation of PV power plant potential under climate change: a case study of El Akarit, Tunisia
Authors: Ben Othman Afef , Ouni Ayoub , Besbes Mongi 
Published: September 2020

Abstract
Background
Several climatologists and experts in the renewable energy field agree that GHI and DNI calculation models must be revised because of the increasingly unpredictable and powerful climatic disturbances. The construction of analytical mathematical models for the prediction of these disturbances is almost impossible because the physical phenomena relating to the climate are often complex. We raise the question over the current and future PV system’s sustainable energy production and whether climate disturbances will be affecting this sustainability and resulting in supply decline.

Methods
In this paper, we tried to use deep learning as a tool to predict the evolution of the future production of any geographic site. This approach can allow for improvements in decision-making concerning the implantation of solar PV or CSP plants. To reach this aim, we have deployed the databases of NASA and the Tunisian National Institute of Meteorology relating to the climatic parameters of the case study region of El Akarit, Gabes, Tunisia. In spite of the colossal amount of processed data that dates back to 1985, the use of deep learning algorithms allowed for the validation of the previously made estimates of the energy potential in the studied region.

Results
The calculation results suggested an increase in production as it was confirmed by the 2019 measures. The findings obtained from the case study region were reliable and seemed to be very promising. The results obtained using deep learning algorithms were similar to those produced by conventional calculation methods. However, while conventional approaches based on measurements obtained using hardware solutions (ground sensors) are expensive and very difficult to implement, the suggested new approach is cheaper and more convenient.

Conclusions
In the existence of a protracted controversy over the hypothetical effects of climate change, making advances in artificial intelligence and using new deep learning algorithms are critical procedures to strengthening conventional assessment tools of the production sites of photovoltaic energy and CSP plants.
Impaired memory for cooperative interaction partners in borderline personality disorder
Authors: Niedtfeld Inga , Kroneisen Meike 
Published: September 2020

Abstract
Background
Interpersonal disturbances in Borderline Personality Disorder (BPD) have been attributed to a negativity bias in social cognition. Adding to this literature, we experimentally tested whether those with BPD show altered memory for cooperative versus non-cooperative interaction partners.

Methods
In a source memory paradigm, 51 female BPD patients and 50 healthy controls (HC) played a trust game with 40 different female target characters (trustworthy vs untrustworthy). In a subsequent surprise memory test, participants had to recognize those target individuals (vs distractor pictures), and had to recall whether they had shown cooperative behavior during the trust game. We hypothesized that BPD patients have better memory for uncooperative interaction partners as compared to cooperative interaction partners, and that a-priori expectations of untrustworthiness would influence recall.

Results
During the trust game, BPD individuals invested lower amounts of money than HC for trustworthy targets, but no differences were found for untrustworthy targets. During the memory test, BPD patients had significant difficulties to remember cooperative targets, as compared to HC. More specifically, those with BPD indicated more often than HC that they had not previously interacted with cooperative targets of the previous trust game. We did not detect any differences between BPD and HC in source memory, or with regard to the effects of trustworthiness expectations.

Conclusions
The observed tendency to forget cooperative interaction partners in BPD is possibly caused by dysfunctional cognitive schemas. At the same time, it might also corroborate patients’ assumptions that others are untrustworthy, thereby fuelling interpersonal disturbances in BPD.
The reconfiguration of biobanks in Europe under the BBMRI-ERIC framework: towards global sharing nodes?
Authors: Argudo-Portal Violeta , Domènech Miquel 
Published: September 2020

AbstractFreezers with biospecimen deposits became biobanks and later were networked at the pan-European level in 2013 under the Biobanking and BioMolecular Resources Research Infrastructure—European Research Infrastructure Consortium (BBMRI-ERIC). Drawing on document analysis about the BBMRI-ERIC and multi-sited fieldwork with biobankers in Spain from a science and technology studies approach, we explore what biobanks are expected to do and become under the BBMRI-ERIC framework, and how infrastructural transitions promote particular transformations in biobanking practices. The primary purpose of biobanks in Europe is presented as being to become mediators in contemporary biomedical research (global sharing nodes) distribution, and distributed nodes of samples and their associated data. We argue that infrastructural transitions are complicated and heterogeneous, giving rise to unattended local concerns on adjusting their practices to fit into the BBMRI-ERIC framework, even for non-members, as the case of Spain illustrates, where “old practices” of collection and storage are questioned. In this article, we aim to encourage qualitative studies to explore the lags between pan-European policies and prospects, different contextual interpretations, and biobanking reconfigurations as an opportunity to explore what that lag is made of (e.g. tensions with “old practices,” unresolved conflicts with the national agendas, reservations on a possible centralization of the biobanking practices by regional biobanks, lack of funding, etc.). Such research could enrich not only policy guidance, but also the understanding of technoscientific infrastructures’ scalability.