bluuebunny/crossref_metadata_2025_split huggingface dataset:
IgG seroprevalence against SARS-CoV-2 in a cohort of 449 non-hospitalized, high-risk exposure individuals.
Authors: Martínez Patricia Torres , García Paula Diaque , Salas María Rubio , Sánchez Raquel Rodríguez , García Felipe , Llamas Miguel Ángel , Saz-Leal Paula , Fresno CArlos del 
Published: August 2020

Abstract
COVID-19 pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection. Mobility restrictions but also the requirement of a medical prescription to gain access to serological testing for COVID-19 were included among the measures. Under this scenario, between April 15th to June 15th, 2020, we performed a seroprevalence observational study including 449 individuals that fulfill prescription requirements: manifesting COVID-19 compatible symptoms, being in contact with a COVID-19 confirmed case or belonging to essential occupations including healthcare workers, firefighters or public safety personnel such as police. Importantly, none of the participants was hospitalized. Altogether, we studied this specific, non-commonly addressed cohort for SARS-CoV-2 seroprevalence, uncovering intrinsic features of great demographic interest. The overall rate of IgG seropositivity was 33.69% (95% CI: 29.27 – 38.21). This seroprevalence was comparable between different occupations performed by the participants. However, contacts with confirmed cases associated positively with IgG+ results, with stronger correlation if being a household member. The number of symptoms also correlated positively with IgG+ prevalence. Ageusia/anosmia, pneumonia and cutaneous manifestations were the top-three symptoms that most strongly associated with IgG+ seroprevalence. However, while pneumonia and cutaneous manifestations were barely present in our cohort, fever, ageusia/anosmia and asthenia were the most frequently symptoms described within IgG+ subjects. Therefore, our data illustrate how specific cohorts display heterogeneous characteristics that should be taken into account when identifying population seroprevalence against SARS-CoV-2 and key defining symptoms for COVID-19.
The Influence of Parental Feeding Knowledge and Practices on Chinese Children and Adolescents’ Weight Status
Authors: Zhang Li , Zhang Yaorong , Qiu Liya , Yang Guangxing 
Published: August 2020

Abstract
Background: Child and adolescent overweight is becoming more prevalent in recent decades. It is imperative to investigate the determinants of children and adolescents’ weight outcomes. Methods: Through analyzing the 2004, 2006, 2009 and 2011 waves of survey data released by China Health and Nutrition Survey (CHNS), this paper investigated the gender and rural-urban differences in terms of the ways in which parental feeding knowledge and practices affected the weight status of Chinese children and adolescents aged 6 to 17. Data were collected through random sampling strategy and logistic regression models were built to conduct analyses.Results: The results showed that feeding knowledge and practices varied by parental residence and were different among mothers and fathers. In addition, parental feeding knowledge, parental eating habits and styles, mother’s intervention on children’s food intakes and physical exercise, and the number of meals parents sharing with children showed significant effects on children and adolescents' weight status. Conclusions: As compared to fathers, mothers’ feeding practices showed more significant effects on children and adolescents’ weight status. The manner in which parental feeding practices influenced children and adolescents’ weight status also differed in rural and urban settings. These findings suggested that mothers were still “gatekeepers” of children and adolescents’ food choices and selection; their feeding practices played a more decisive role on Chinese youth’s weight status. The urban-rural differentials highlighted in this research also reminded us that the “one-fits-all” solutions to prevent youth’s obesity should be avoided.
The relationship between hormone receptor status, tumor size and clinical stage and the efficacy of neoadjuvant chemotherapy for locally advanced breast cancer, predictors of survival, and the establishment of Cox-Based risk prediction model and nomogram
Authors: Fengjiao Gan , Mengxi Xu , Xiaomei Li , Lian Wang , Mingyue Zhang , Lin Xu , Qiaoyuan Wu , Ni Jiang , Kang Hu , Yi Li , Suhong Sun , Qing Luo 
Published: August 2020

Abstract
Background: Neoadjuvant chemotherapy is currently mainly used for locally advanced breast cancer. However, there is currently no effective way to predict the prognosis of neoadjuvant chemotherapy patients. Methods: All relevant data before and after chemotherapy were collected and evaluate the efficacy of chemotherapy through RECIST1.1 and pathology. Survival curves were generated by the Kaplan-Meier method and compared using the log-rank test. A nomogram was developed using a binary logisti regression model with a cross validation. Results: A total of 158 patients were included in our study. The ORR was 64.6% (cCR, 3.8%; cPR, 60.8%). The pCR rates wer 12.0% for breast tumor and axillary nodes. The pCR rates were 17.1% for breast tumor and 30.4% for axillary nodes. Our study found that only differences in HER-2 status could predict different clinical efficacy, and clinical remission (CR+PR) was more likely to be achieved if HER-2 positive than negative (16.7% vs 7.5%, p=0.05). There was no significant difference in the clinical efficacy of neoadjuvant chemotherapy in age, clinical stage, and molecular classification of patients. In a single factor COX proportional hazard model study, it was found that ER positive relative to HR negative(HR 0.479,CI 95% 0.272-0.844, p=0.011), PR positive relative to PR negative (HR 0.423,CI 95% 0.235-0.763, p=0.004), HER-2 positive relative to HER-2 negative (HR 2.011, CI 95% 1.000-4.042, p=0.050), TNBC (HR 2.229, CI 95% 1.189-4.178, p=0.012), and HER-2 (HR 2.808, CI 95% 1.301-6.062, p=0.009) type are more effective than patients with Luminal type breast cancer 0btain a longer survival time, which is considered a protective factor. A nomogram was developed based on the clinical and statistically significant predictors. ROC curve for 3-year survial with area under the curve = 0.731 (95% confidence interval, 0.663-0.828); ROC curve for 5-year survial with area under the curve = 0.743 (95% confidence interval, 0.652-0.834); ROC curve for 10-year survial with area under the curve = 0.726 (95% confidence interval, 0.639-0.812). Conclusion: In conclusion, the hormone receptor status before chemotherapy can predict the prognosis of patients in advance, and we successfully constructed nomogram, which can help us predict the OS of patients with NAC.
A Cross-sectional Study Exploring Sex Differences in the Relationship Between Sex Partner Attitudes and Current Quit Attempt Among a Sample of Smokers in Baltimore, MD, USA.
Authors: A. Davey-Rothwell Melissa , Crossnohere Norah , Hammond Paige , Tseng Tuo-Yen , Whittington Marlesha , Tobin Karin , Latkin Carl , Knowlton Amy 
Published: August 2020

Abstract
Background: Limited research has explored sex differences in the relationship between partner behavior and attitudes and smoking cessation. Methods: The study examined sex partner attitudes about smoking among men and women who are currently trying to quit smoking cigarettes. Data were collected as part of the Tobacco Use in Drug Environment (TIDE) study, a cross-sectional study conducted in Baltimore, MD, USA from September 2013-May 2015. Interviews were administered with current smokers. The sample size for the current analysis was 134 men and 86 women. Results: Approximately thirty-three percent of male participants (n=45) reported currently trying to quit smoking cigarettes. Twenty-nine percent of women were currently trying to quit. Having a sex partner who did not mind the participant’s smoking was associated with decreased odds of trying to quit among men (AOR=0.35, p=0.03, 95% CI: 0.13, 0.91). Having a sex partner who expressed concern about the participant’s smoking (AOR=12.9, p<0.01, 95% CI: 3.49, 47.0) and having a sex partner who encouraged the participant to quit smoking was significantly associated current quit attempt. Conclusions: The relationship between partner support for cessation and current quit attempt was stronger for women than men in this population. Understanding sex-partner attitudes regarding smoking and their relationship to smoking cessation activities may provide insights for future tailored cessation interventions.
Relationship Between Physical Activity and the Availability of Exercise Facilities in an Urban Elderly Population: Cross-sectional Results from China
Authors: Wang Houlei , Wang Zhu ying , Kang Douye , Zhang xuhui , WU Zhi-jian 
Published: August 2020

Abstract
BACKGROUND: Sports facilities have great potential in promoting physical activity. Few studies have explored this relationship in the elderly. Therefore, this study explored the relationship between the community availability of sports facilities and physical activity levels in the elderly. METHODS: Overall, 569 elderly individuals (56.9% female) were randomly selected from 32 communities in Nanjing City. Participants were given accelerometers to wear for 4 consecutive days. A global positioning system and ActiGraph GT3+ device ware used to track, measure duration, and determine spatial details of outdoor activities. It was used to measure the availability of sports facilities within a 500-m buffer zone around the residence of the elderly. Sociodemographic variables and community types were included as covariates. RESULTS: Elderly individuals having 6–7 sports facilities in their buffer zone spent 9.19 minutes (95% confidence interval: 0.05–18.33) longer exercising than did individuals without facilities. Sex, age, and community type significantly influenced the duration of physical activity. After controlling for confounding factors, the physical activity standard reaching rate of the elderly with access to 6–7 sports facilities was 118% higher than that of elderly individuals without access. Further, the compliance rate of the elderly aged 60–65 years and the marginal community was relatively higher. The availability of sports facilities was associated with the probability of achieving the recommended amount of physical activity and moderate to high outdoor physical activity levels of the elderly. CONCLUSIONS: We show that the promotion of physical activity and the improvement of health status are based on facility availability, which in turn affects the physical activity levels of the elderly.
Role of Temporal Discounting in a Conditional Cash Transfer (CCT) Intervention to Improve Engagement in the Prevention of Mother-to-child Transmission (PMTCT) Cheaascade
Authors: Saleska Jessica Londeree , Turner Abigail Norris , Gallo Maria F. , Shoben Abigail , Kawende Bienvenu , Ravelomanana Noro Lantoniaina Rosa , Thirumurthy Harsha , Yotebieng Marcel 
Published: August 2020

Abstract
Background: Temporal discounting (TD), the tendency of individuals to discount future costs and benefits relative to the present, is often associated with greater engagement in risky behaviors. Incentives such as conditional cash transfers (CCTs) have the potential to counter the effects of TD on health behaviors. We hypothesized that CCTs work by mitigating the effects of high TD, measured using a delay-discounting task. Methods: We conducted an interaction analysis using data from a randomized trial of a CCT intervention among 434 HIV-positive pregnant women in the Democratic Republic of Congo. The analysis focused on two outcomes: 1) retention in HIV care, and 2) uptake of prevention of mother-to-child transmission (PMTCT) services. Results: The effect of TD on retention was small, and we did not observe evidence of interaction between TD and CCT on retention. However, our findings suggest that CCT may mitigate the negative effect of high TD on uptake of PMTCT services (interaction contrast (IC): 0.18, 95% CI: -0.09, 0.44). Conclusions: Our findings support the continued use of small, frequent incentives, to motivate improved uptake of PMTCT services, especially among women exhibiting high TD.
Assessment of Serum Vitamin D3 Level in One Year Old Children Using D3 Supplement
Authors: Alebouyeh Danial , Khalessi Nasrin , Saboute Maryam , Chamkhaleh Maryam Alizadeh , Kashaki Mandana 
Published: August 2020

Abstract
Introduction. Vitamin D status is a key determinant of bone health and growth during childhood and adolescence. Therefore, we design a study to find out the association between the levels of serum vitamin D and need to consumption of vitamin D supplement.Method and materials. In this cross sectional study infants under 20 months referred to Ali Asghar Children's Hospital were included. Infants with maternal diseases and congenital malformations were excluded. All infants used vitamin D3 supplementation 400 IU per day from day fifth of birth. The level of 25-hydroxy vitamin D at the age of 1 years (month 12) were measured. Level of 25-hydroxy vitamin D in mothers were checked, too. Furthermore, we defined sufficient level of 25-hydroxy vitamin D ≥30ng/ml.Results. In this study, 68 infants under 20 months were examined. Half of them were boy. Mean age of infants was 16±3 months and mothers was 33±3 years old. In addition, the mean level of serum 25-hydroxy vitamin D in the infants were 40.99±13.86 ng/ml and in mothers were 31.39±13.14 ng/ml. 62.1% of mothers were in sufficient group and also 83% of infants had sufficient vitamin D level (25-hydroxy vitamin D ≥ 30ng/ml). There was not any significant correlation between vitamin D level in infants and mothers (P value=0.965). The mean level of serum vitamin D3 in boys was 39.55±3.79 ng/ml (12-51) and girls was 35.32±3.67 ng/ml (13.4-50). Similarly, significant relationship was not shown between gender and vitamin D of infants (P value = 0.437). Level of vitamin D in second children was significantly higher than first children (P value=0.011). The correlation between gestational age and vitamin D3 deficiency was also insignificant (P value=0.087). Head circumference (r= -0.404, P value=0.014) and age of mothers (r= 0.344, P value=0.04) correlated with vitamin D.Conclusion. In summary, we demonstrated most of the infants had sufficient vitamin D level at the age of 1 year. So it is recommended to continue vitamin D3 supplementation consumption.
Effects of Task-Specific Virtual Reality Training Using a Leap Motion Controller on Hemiparetic Upper Extremity in Patients with Stroke
Authors: Fong Kenneth N. K. , TANG Y. M. , SIE Karen , YU Andy K. H. , LO Cherry C. W. , MA Yuko W. T. 
Published: August 2020

Abstract
Background: Task-specific training has been proven to be effective in promoting recovery of the hemiparetic upper extremities after a stroke. This study was to develop a new and innovative task-specific VR (TS-VR) program using a Leap Motion Controller VR device and the Unity3D program for distal hand function training, and to investigate whether a two-week program of TS-VR training would promote recovery of the hemiparetic upper extremity in patients with chronic stroke.Methods: We designed the TS-VR program based on seven general hand function tasks used in the activities of daily living that require upper limb movement, such as pushing open a door and pouring water. Then, we examined the content validity of the TS-VR according to the views of an expert panel and through field testing on patients with stroke. The final version of the TS-VR was tested on 20 patients suffering from chronic stroke with upper extremity hemiparesis over 2 weeks, 5 sessions per week, 30 minutes per session. Outcomes were assessed using the Fugl-Meyer Assessment-Upper Extremity score (FMA-UE), the Wolf Motor Function Test (WMFT), and the Motor Activity Log (MAL). Data were collected at the first session (week 0), last session (week 2), and follow-up session (week 5). Patients’ arm impairments were stratified into lower- and higher-functioning groups according to the Functional Test for the Hemiplegic Upper Extremity (FTHUE).Results: Significant improvements in upper extremity functions were found after TS-VR training in FMA-UE Total score (χ2=34.219, p=0.000), FMA-UL subscore (χ2=31.2, p=0.000), FMA-Hand subscore (χ2=22.6, p=0.000), and WFMT score (χ2=27.8, p=0.000) among the three time occasions, but no significant effect on grip strength was found. Moreover, the higher-functioning group (levels 5-7 in FTHUE) benefited more from the TS-VR, as indicated in outcome measures of FMA-UL, FMA-Hand, FMA-UE Total, and WMFT respectively, as well as amount of use score in MAL, but this was not the case for those in the lower-functioning group (levels 1-4 in FTHUE).Conclusions: Our findings suggest that our new TS-VR training system was useful for upper extremity recovery in patients with chronic stroke. It has potential to be applied in clinical settings in future.
Technology-Based Interventions for Nursing Home Residents: Implications for Nursing Home Practice Amid and Beyond the Influence of COVID-19: A Systematic Review Protocol
Authors: Su Zhaohui , Meyer Kylie , Li Yue , McDonnell Dean , Joseph Nitha Mathew , Li Xiaoshan , Du Yan , Advani Shailesh , Cheshmehzangi Ali , Ahmad Junaid , Veiga Claudimar Pereira da , Chung Roger Yat-Nork , Wang Jing 
Published: August 2020

Abstract
Background: A growing number of technology-based interventions are used to support the health and quality of life of nursing home residents. The onset of COVID-19 and recommended social distancing policies that followed led to an increased interest in technology-based solutions to provide healthcare and promote health. Yet, there are no comprehensive resources on technology-based healthcare solutions that describe their efficacy for nursing home residents. This systematic review will identify technology-based interventions designed for nursing home residents and describe the characteristics and effects of these interventions concerning the distinctive traits of nursing home residents and nursing facilities. Additionally, this paper will present practical insights into the varying intervention approaches that can assist in the delivery of broad digital health solutions for nursing home residents amid and beyond the impact of COVID-19.Methods: Databases including PubMed, PsycINFO, CINAHL, and Scopus will be used to identify articles related to technology-based interventions for nursing home residents published between January 1st, 2020 to July 7th, 2020. Titles, abstracts, and full-texts papers will be reviewed against the eligibility criteria. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses procedures will be followed for the reporting process, and implications for existing interventions and research evaluated by a multidisciplinary research team.Results: NA—protocol studyConclusions: Our study will fill critical gaps in the literature by providing a review of technology-based interventions tested in the nursing home setting. As the older adult population grows, there is an urgent need to identify effective technology-based interventions that can address the distinctive characteristics and preferences of nursing home residents. Clear and comprehensive understanding of how available technology-based health solutions facilitate healthcare for nursing home residents will shed light on the approaches open to residents to fend off the negative health consequences amid and beyond the influence of COVID-19.Systematic Review Registrations: PROSPERO CRD 42020191880
Construction of a protein-based model for prognosis prediction of kidney renal clear cell carcinoma: an investigation based on functional proteomics data
Authors: Jiang Huiming , Chen Haibin , Wan Pei , Chen NanHui 
Published: August 2020

Abstract
Background

Several studies have shown prognostic value of gene-based models at mRNA level in kidney renal clear cell carcinoma (KIRC). However, protein-based models for prognosis prediction of KIRC are rarely reported, then we conduct this study.
Methods

Proteomics and clinical data of KIRC were acquired from The Cancer Proteome Atlas (TCPA) and The Cancer Genome Atlas (TCGA), respectively. Prognosis-associated proteins were screened by univariate Cox regression analysis and log-rank test. Patients were grouped into training set and testing set. The protein-based prognostic model was constructed by lasso Cox regression analysis in training set and validated in test set and whole set.
Results

A five-protein model (ACC1, IGFBP2, MIG6, PEA15 and RAD51) was constructed for KIRC prognosis prediction. It could well classify KIRC patients into high-risk and low-risk group with significantly different survival. The results was validated in the testing set and whole set. Age, AJCC stage and risk score based on the five-protein model were identified as independent prognostic parameters and they were used to construct a nomogram. The calibration plot showed the nomogram had good agreement between predicted and actual outcomes. Time-dependent ROC curves revealed the nomogram performed best in predicting the 1-year, 3-year and 5-year overall survival (OS) compared with other independent prognostic parameters. DCA demonstrated the nomogram had obviously clinical net benefit. Furthermore, several cancer-related biological signaling pathways were enriched in the functional enrichment analysis.
Conclusion

Our study developed an effective protein-based model to predict the OS of KIRC, which may help clinicians to offer individual treatment.
Salvia miltiorrhiza alleviates hypoxia-induced nerve injury associated with Ngb/Akt intracellular signaling pathway
Authors: Zhang Xianxie , Qiu Haiying , Kong Jian , Wu Yan , Yuan Hailong 
Published: August 2020

Abstract
Background: Salvia miltiorrhiza (Danshen), a traditional Chinese herbal medicine, can effectively improve the high-altitude adverse reactions of high-altitude patients. While, the mechanism of how they exert neuroprotective effect to intervene the hypoxic at high altitudes is still not well understood.Methods: The study established high altitude hypoxia mouse model and CoCl2 -induced PC12 cell hypoxia model , the protective effects of S. miltiorrhiza radix extract (SE), Tanshinone IIA (Tan IIA) and salvianic acid A sodium (SAS) on hypoxia model were studied in vitro and in vivo.Results: The results showed that SE, TanⅡA, and SAS are able to improve biochemical level in high altitude hypoxia mouse model, increase in Ca2+ concentration, and decrease in MMP, inhibit apoptosis in CoCl2 -induced PC12 cell hypoxia model by activating Akt signaling pathway, protecting neurons, thus improving the oxygen carrying capacity of brain tissue.Conclusion: This study confirms the efficacy of SE, Tan Ⅱ A, and SAS with respect to therapeutic treatment of hypoxia, shown that S. miltiorrhiza and its active monomers can protect neurons by activating Ngb/Akt intracellular signaling pathway, and attenuate cerebral anoxia and neuronal damage, subsequently nerve injury caused by hypoxia at high altitude. Providing important information for the clinical treatment of nerve injury caused by hypoxia at high altitude.