bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of home delivery and associated factors in Ethiopia: A systematic review and meta-analysis
Authors: Ayenew Asteray Assmie , Nigussie Azezu , Zewdu Biruk 
Published: June 2020

Abstract
BackgroundGlobally, maternal morbidity and mortality remained a major public health challenge. Delivering at home is associated with a higher risk of maternal deaths. Findings on the prevalence and associated factors of home delivery are highly variable and inconsistent across Ethiopia. Therefore, the aim of this systematic review and meta-analysis was to estimate the pooled prevalence of home delivery and its associated factors in Ethiopia.MethodPreferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. The databases used were; PubMed, Google Scholar, Cochrane Library, African Journals Online, Ethiopian's university research repository online library, and manual searching. The search was further limited to studies conducted in Ethiopia and reported in English. Two authors independently extracted all necessary data using a standardized data extraction format. STATA 11 software was used to analyze the data. The Cochrane Q and I2 test were used to assess the heterogeneity of studies. The pooled estimate prevalence and the odds ratios with 95% confidence intervals were computed by a random effect model.ResultA total of 13 studies were included in this meta-analysis with a sample size of 13,535. The national pooled prevalence of home delivery was 48.53 % (95% CI:35, 62). The pooled adjusted odds ratio (AOR) of home delivery for Place of rural residence was 4.3(AOR = 4.3; 95% CI 2.7, 6.8), husband preference was 5(AOR=5.1 95%CI:1.1, 22), not having ANC follows up was 3.3(AOR= 3.3,95%CI:2,6), Women who cannot read & write was 4(AOR=4.36,95% CI:3.1, 6.12), Primary level was 4(AOR=4.21, 95%CI:1.5, 11.6) ,and secondary & above was 1.9(AOR=1.9,95%CI:1.1, 3.45), distance from the health facility was 7(AOR= 7.33, 95%CI:5.75, 9.35), age of mothers 15-24 was 4(AOR =3.7,95%CI:2, 6.6), knowledge of danger sign of pregnancy was 4(AOR=4.60 95%CI:3, 6.8), and no media access was 3.4(AOR=3.495%CI: 1.5, 7.5).ConclusionThis systematic review and meta-analysis showed that home delivery was high in Ethiopia. Place of residence, husband preference, no having ANC follows up, educational status of mothers, distance from health facility, age of mothers, knowledge of danger sign of pregnancy, and no media access increased the risk of home delivery.
Self-esteem instability and affective instability in everyday life after remission from borderline personality disorder
Authors: Santangelo Philip Samuel , Kokler Tobias D. , Zeitler Marie-Luise , Knies Rebekka , Kleindienst Nikolaus , Bohus Martin , Ebner-Priemer Ulrich W. 
Published: June 2020

Abstract
Background: Borderline personality disorder (BPD) is defined by a pervasive pattern of instability. According to prior findings and clinical theories, self-esteem instability and affective instability are key features of BPD. Previous e-diary studies showed that instability in self-esteem is heightened and that it is highly intertwined with affective instability in BPD in comparison to healthy controls (HC). The present study sought to extend these findings by adding symptomatologically remitted BPD patients (BPD-REM), i.e. former patients with BPD who met four or fewer BPD criteria within the past year, as a comparison group.Methods: To examine differences regarding self-esteem instability and affective instability, we used e-diaries for repeatedly collecting data on self-esteem, valence, and tense arousal 12 times a day for four consecutive days while participants underwent their daily life activities. Determining three different state-of-the-art instability indices and applying multilevel analyses, we compared 35 BPD-REM participants with previously reported 60 acute BPD patients (BPD-ACU) and 60 HC.Results: Our results revealed that self-esteem instability was significantly lower in the BPD-REM compared to the BPD-ACU group, irrespective of the instability index. In contrast, there were no significant differences regarding affective instability between the BPD-REM participants and those in the BPD-ACU group. The comparison between the BPD-REM with the HC indicated both a significantly higher instability in self-esteem as well as significantly heightened affective instability in the BPD-REM participants. Moreover, even though the associations were not significant, we found tentative support for the assumption that affective changes that are accompanied by changes in self-esteem are experienced as more burdensome and negatively impact the quality of life of remitted BPD participants.Conclusions: This study builds on growing evidence for the importance of self-esteem instability in BPD. Whereas affective instability has been reported in various psychiatric disorders and might indeed constitute a transdiagnostic marker of affective dysregulation, our results indicate that self-esteem instability might be a specific symptom that construes the unique pathology in BPD.
Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer.
Authors: sun dantong , Tian Lu , Zhu Yan , Wo Yang , Liu Qiaoling , Liu Shihai , Li Hong , Hou Helei 
Published: June 2020

Abstract
IntroductionPatients with advanced non-small cell lung cancer (NSCLC) benefit from treatment with immune checkpoint inhibitors (ICIs). Biomarkers such as programmed death-ligand 1 (PD-L1), the tumor mutational burden (TMB) and the mismatch repair (MMR) status are used to predict the prognosis of ICI therapy. Nevertheless, novel biomarkers need to be further investigated, and a systematic prognostic model is needed for the evaluation of the survival risks of ICIs.MethodsA cohort of 240 patients who received ICIs from the cBioPortal for Cancer Genomics was evaluated in this research. Clinical information and targeted sequencing data were acquired for analyses. The Kaplan-Meier plot method was used to perform survival analyses, and selected variables were then confirmed by a novel nomogram constructed by the “rms” package of R software.ResultsSeven percent of the NSCLC patients harbored ARID1A mutations, while 4% of the NSCLC patients harbored ARID1B mutations. Mutations in ARID1A or ARID1B were confirmed to be associated with sensitivity to ICIs. Patients harboring these mutations were found to have a better response to treatment (ARID1A: P=0.045; ARID1B: P=0.034) and prolonged progression-free survival (ARID1B: P=0.032). Here, a novel nomogram was constructed to predict the prognosis of ICIs. Elevation of the TMB, enhanced expression of PD-L1 and activation of the antigen presentation process and cellular immunity were found to be correlated with ARID1A or ARID1B mutations.ConclusionARID1A and ARID1B could serve as novel biomarkers for the prognosis and sensitivity to ICIs of advanced NSCLC.
Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens – the ECM receptor interaction signaling pathway
Authors: Du Yanting , San Jishuang , Wu Gaofeng , Xu Rifeng , Yang Jiancheng , Hu Jianmin 
Published: June 2020

Abstract
Background Meat quality characteristics, including juiciness, flavor, and tenderness, can be mostly attributed to the total muscle fat content, intramuscular fat (IMF), and the composition of its fatty acids (FAs), which are regulated by the balance between lipid uptake, transport, synthesis, and subsequent metabolism, involving many genes and pathways. However, the detailed molecular mechanisms remain unclear. Results The present study reports the RNA-sequencing (RNA-seq) analysis of chest muscle and leg muscle tissue of the Zhuanghe dagu chicken (ZD chicken) and the Arbor Acres Broiler chicken (AA chicken). We identified certain differentially expressed genes that affect IMF deposition , such as EHHADH , TECRL , NDUFAB1 , PCCB , and HIBCH , which were upregulated in ZD chickens, and GCDH , TPI1 , ABHD13 , PSMC1 , MYST2 , and FBXO11 , which were upregulated in AA chickens. Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes indicated that the extracellular matrix (ECM)–­receptor interaction pathway is co-enriched in both tissues, and forms a sub-pathway of other enriched pathways. Intriguingly, the ECM–receptor interaction pathway genes are regulated differently in different gene pools. Collagens, which are main ECM constituents, and laminin and integrinβ1 transmembrane receptors were significantly downregulated in both tissues of the AA chicken. Conclusions RNA-seq analysis of two tissues from two breeds of chicken hinted that interactions between transmembrane receptors and ECM components of fat cells affect breed-specific adipogenesis, which would affect quality and flavor of chicken meat. These findings will contribute to improving the quality attributes of chicken meat.
Extracorporeal Membrane Oxygenation and Prone Position Ventilation on Critically ill COVID-19: A Case Report and Literature Review
Authors: Zhang Jingchen , He Xujian , Hu Jia , Chen Chenkan , Ye Xuesheng , Li Tong 
Published: June 2020

Abstract
Background: COVID-19 broke out all over the world, and the mortality rate is extremely high. We report the successful experience of a critically ill COVID-19 patient who underwent long-term extracorporeal membrane oxygenation (ECMO) and multiple prone position ventilation (PPV) treatments.Case presentation: A 53-year-old male patient was sent to our hospital after 11 days of cough and 9 days of fever. According to his CT scan and real-time reverse transcription–polymerase chain reaction assay to throat swap, his nucleic acid was positive, confirming that he was infected with COVID-19. Subsequently, he was sent to ICU for respiratory failure. Afterwards, the patient received antiviral drug, tiny amount of glucocorticoid, and respiratory support, including mechanical ventilation, but the affect was poor. In the 28th day of his admission, veno-venous ECMO and PPV were used, combining with awake ECMO and other comprehensive rehabilitation. In the 17th day of ECMO, the patient started getting better and his chest CT and lung compliance improved. The ECMO was removed in the 27th days, after which the mechanical ventilation was gotten rid of in the 9th day. Then he was transferred to rehabilitation department.Conclusions: COVID-19 can damage lung tissues and cause evident inflammatory exudation, affecting oxygenation function. It is effective to use PPV, awake ECMO, and comprehensive rehabilitation to cure patients with critical COVID-19 and respiratory failure. Our experience hopes to be promoted to play a positive role.
Nanocomposites-Based Targeted Oral Drug Delivery Systems with Infliximab in a Murine Colitis Model
Authors: Kim Jung Min , Kim Da Hye , Park Hyo Jeong , Ma Hyun Woo , Park I Seul , Son Mi jeong , Ro So Youn , Hong SeokMann , Han Hyo Kyung , Lim Soo Jeong , Kim Seung Won , Cheon Jae Hee 
Published: June 2020

Abstract
Infliximab (IFX), a TNF-α blocking chimeric monoclonal antibody, induces clinical response and mucosal healing in patients with inflammatory bowel disease (IBD). However, systemic administration of this agent causes unwanted side effects. Oral delivery of antibody therapeutics might be an effective treatment strategy for IBD compared to intravenous administration. We developed a colon-specific drug delivery system for the oral administration of IFX using ternary nanocomposite carriers. Nanocomposite carriers consisting of liposomes, aminoclay-coated liposomes (AC-L), Eudragit S100 AC-L (EAC-L) or those carrying IFX (IFX-L, AC-IFX-L, and EAC-IFX-L) were orally administered to mice with dextran sulfate sodium-induced colitis. We evaluated the effects of nanocomposite carriers on lymphocytes and monocytes in peripheral blood mononuclear cells (PBMC) of IBD patients. We studied the therapeutic effects of the nanocomposites themselves and nanocomposites with IFX at target sites in vivo and in vitro . All three carriers had a high encapsulation efficiency, narrow size distribution, and minimal systemic exposure. There was a higher interaction between nanocomposite carriers and monocytes compared to lymphocytes in the PBMC of IBD patients. Orally administered nanocomposite carriers targeted to inflamed colitis minimized systemic exposure. All IFX delivery formulations with nanocomposite carriers had a significantly less colitis-induced body weight loss, colon shortening and histomorphological score, compared to the DSS-treated group. AC-IFX-L and EAC-IFX-L groups showed significantly higher improvement of the disease activity index, compared to the DSS-treated group. In addition, AC-IFX-L and EAC-IFX-L alleviated pro-inflammatory cytokine expressions ( Tnfa , Il1b , and Il17 ). We present orally administered antibody delivery systems which improved efficacy in murine colitis while reducing systemic exposure. These oral delivery systems suggest a promising therapeutic approach for treating IBD.
Struvite stones causing recurrent pain in a child with cerebral palsy: a lesson for a pragmatic approach to pain in children with cerebral palsy and cognitive impairment.
Authors: Trombetta Andrea , Benvenuto Simone , Peri Francesca , Grasso Antonio Giacomo , Magnolato Andrea , Barbi Egidio , Cozzi Giorgio 
Published: June 2020

Abstract
Background

Children with severe cognitive impairments (CI) from any cause, such as cerebral palsy (CP), dysmorphic or chromosomal syndromes, traumatic brain injury, neurodegenerative disorders, and epileptic syndromes, experience pain more frequently than healthy peers. Although it is a common problem, pain is many times unrecognized because these patients are often unable to self- verbalize it or exhibit uncommon behaviors when they experience it, leading to a delay in the recognition and management of pain by the physicians. Untreated chronic or recurrent pain profoundly affects the quality of life of these children and interferes with their performance and adaptive function. Recognition, measurement, and treatment of pain in this population is challenging, and a clinical diagnosis of urinary tract infection or lithiasis may not be immediate.
Case presentation:

We report the case of an eight-year-old child with cerebral palsy who was admitted for recurrent abdominal pain lasting for one month. While blood laboratory tests were all in the normal range, the diaper examination revealed multiple stones. Urine culture tested positive for Providencia stuartii, a Gram-negative bacteria, and an antibiotic treatment with ceftibuten was started for two weeks. The patient fully recovered in three days without any recurrence.
Conclusions

urine analysis, to detect an infection, and renal and bladder US, to rule out stones, should be systematically considered in patients with cognitive impairment with unexplained pain. In a pragmatic, concise approach, the basic principles of diagnosis and treatment of pain in children with cognitive impairment are reviewed.
Four-year Follow up of Atherogenicity in Rheumatoid Arthritis Patients: From Nationwide Korean College of Rheumatology Biologics Registry
Authors: Min Hong Ki , Kim Hae-Rim , Lee Sang-Heon , Shin Kichul , Kim Hyoun-Ah , Park Sung-Hwan , Kwok Seung-Ki 
Published: June 2020

Abstract
Background: To evaluate the impact of biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) on lipid profile and atherogenic index of plasma (AIP) in rheumatoid arthritis (RA) patients, and to compare the occurrence of dyslipidaemia between patients using bDMARDs, tsDMARDs, or conventional DMARDs (cDMARDs).Methods: Data for lipid profile, AIP, and occurrence of dyslipidaemia were collected from the Korean College of Rheumatology BIOlogics registry. A comparison was conducted between patients using bDMARDs (tumour necrosis factor (TNF)-α inhibitor, tocilizumab, abatacept), janus kinase inhibitors (JAKis), and cDMARDs. The Kaplan-Meier method was used to compare the occurrence of dyslipidaemia between groups, and hazard ratios (HR) were calculated using the cox proportional hazard method.Results: Data of a total of 917, 826, 789, 691, and 520 RA patients were eligible for analysis at the baseline, 1-year, 2-year, 3-year, and 4-year follow ups, respectively. Baseline total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and triglyceride (TG) were higher in the cDMARDs group, whereas AIP was comparable. During the 4-year follow up, AIP was comparable between the groups. Occurrence of dyslipidaemia did not show a significant difference when comparing the bDMARDs/tsDMARDs and cDMARDs groups (P=0.06), or the TNF-α inhibitor, tocilizumab, abatacept, JAKi, and cDMARD user groups (P=0.3). In the multivariate cox proportional hazard model, older age (HR=1.03, P=0.005) and concomitant hypertension (HR=2.21, P=0.013) were significantly associated with dyslipidaemia occurrence.Conclusion: Long term use of bDMARDs and tsDMARDs is relatively safe with regards to lipid profile, AIP, and the occurrence of dyslipidaemia in RA patients.
A novel peptide analogue of spike glycoprotein shows antiviral properties against SARS-CoV-2
Authors: Dutta Kunal 
Published: June 2020

Abstract
At the very beginning of the new decade, the COVID-19 pandemic has badly hit the globe. SARS-CoV-2, the causative agent of COVID-19 carries dozens of new mutations in its genome. Multiple countries are now in the race to find a defined treatment and vaccine against COVID-19. Herein, we made an effort to find antiviral peptides against SARS-CoV-2. Gladly, with the help of Machine Learning algorithms and Supported Vector Machine, we have found three potential antiviral peptides against SARS-CoV-2. Antiviral peptides namely, Seq12 and Seq12m showed very low cytotoxicity. All antiviral peptides were able to block the RBD of the spike glycoprotein. Besides, antiviral peptides retain their properties even in case of in silico multi-point mutant models (Rosetta and FoldX based) of RBD. Moreover, Seq12, Seq12m, and Seq13m can bind with the viral membrane protein (M) and eventually interfere with viral re-packaging. In conclusion, this study suggests Seq12, Seq12m, and Seq13m holds the potential for possible therapeutics use after formal clinical trials. Besides, these antiviral peptides could aid a new diagnostic tool.
Cotton N rate could be reduced further under the planting model of late sowing and high-density in Yangtze River Valley
Authors: song xinghu , Huang Ying , Yuan Yuan , Tung Shahbaz Atta , Souliyanonh Biangkham , Yang Guozheng 
Published: June 2020

Abstract
Background
An optimal N rate is one of the basic determinants for high cotton yield. The purpose of this study was to determine the optimal N rate on a new cotton cropping pattern with late-sowing, high density and one-time fertilization at first flower in Yangtze River Valley China. A 2-year experiment was conducted in 2015 and 2016 with a randomized complete blocks design, and cotton growth process, yield and biomass accumulation were examined.
Results
The results showed that N rate had no effect on cotton growing progress or periods. Cotton yield was increased with N rate increasing from 120–180 kg ha− 1, while the yield was not increased when N was beyond 180 kg ha− 1, or even decreased (9–29%). Cotton had the highest biomass at N180 due to its highest accumulation speed during the fast accumulation period (FAP).
Conclusions
The result suggests that cotton N rate could be reduced further to be 180 kg ha− 1 under the new cropping pattern in Yangtze River Valley China.
Green Synthesis of Nano-Liposomes Containing Bunium Persicum and Trachyspermum Ammi Essential Oils Against Trichomonas Vaginalis
Authors: Mirzaei Farzaneh , Norouzi Roghayeh , Siyadatpanah Abolghasem , Haghirosadat Bibi Fatemeh , Rezaei Fatemeh , Nissapatorn Veeranoot , Mitsuwan Watcharapong , Nawaz Muhammad , Pereira Maria L. , Hosseini Seyed Abdollah , Montazeri Mahbobeh , Majdizadeh Mohammad 
Published: June 2020

Abstract
Background: Trichomonas vaginalis, a parasitic flagellated protozoan, is one of the main non-viral sexually-transmitted diseases worldwide. Treatment options for trichomoniasis are limited to nitroimidazole compounds. However, resistance to these drugs has been reported, which requires the development of new anti-Trichomonas agents that confer suitable efficacy and less toxicity.Methods: In the present work, we assessed the effectiveness of the liposomal system containing essential oils of Bunium persicum and Trachyspermum ammi against T. vaginalis in vitro. Liposomal vesicles were prepared with phosphatidylcholine (70%) and cholesterol (30%) using the thin-film method. The essential oils of B. persicum and T. ammi were loaded into the liposomes using the inactive loading method. Liposomal vesicles were made for two plants separately. Their physicochemical features were tested using Zeta-Sizer, AFM and SEM. The anti-Trichomonas activity was determined after 12 and 24 hours of parasite cultures in TYI-S-33 medium.Results: After 12 and 24 hours of administration, the IC50 of the B. persicum essential oil nano-liposomes induced 14.41 µg/mL and 45.19 µg/mL, respectively. The IC50 of T. ammi essential oil nano-liposomes induced 8.08 µg/mL and 25.81 µg/mL, respectively.Conclusions: These data suggested that nano-liposomes of the essential oils of B. persicum and T. ammi may be a promising alternative to current treatments for Trichomonas infection.
The emergence of SARS-CoV-2 by an unusual genome reconstitution
Authors: Hong Seong-Tshool , Hassan Md. Mehedi , Sharmin Shirina , Hong Jinny , Lee Hoi-Seon , Kim Hyeon Jin 
Published: June 2020

Abstract
SARS-CoV-2 has been spreading remarkedly fast around the world since its emergence while the origin of the virus remains ambiguous. Here, we constructed all of the original prototype genome sequences of SARS-CoV-2 by selecting the common nucleotide among the different virus strains with species. Phylogenetic analysis on the prototype sequences showed that SARS-CoV-2 was a direct descendant of Bat-CoV and was closely related to Pan-CoV, Bat-SL-CoV, and SARS-CoV. The pairwise comparison of SARS-CoV-2 with Bat-CoV showed an unusual replacement of the motif consisting of 7 amino acids within the spike protein of SARS-CoV-2. Database searches showed that the motif originated from a surface protein of Plasmodium malariae, suggesting that the SARS-CoV-2 was emerged after acquiring the motif of the malaria surface protein.