bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares
Authors: Chau Alice S , Cole Bonnie L , Debley Jason S , Nanda Kabita , Rosen Aaron BI , Bamshad Michael J , Nickerson Deborah A , Torgerson Troy R , Allenspach Eric J 
Published: March 2020

Abstract
Background: Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal recessive disorder with hallmark features of direct antibody negative hemolytic anemia with normal bilirubin, hyperinflammation and features similar to macrophage activation syndrome. Clinical findings have included asplenia, nephritis, hepatitis, and vasculitis. Pulmonary features and evaluation of the immune response have been limited.Case presentation: We present a young boy who presented with chronic respiratory failure due to nonspecific interstitial pneumonia following a chronic history of infection-triggered recurrent hyperinflammatory flares. Episodes included hemolysis without hyperbilirubinemia, immunodeficiency, hepatomegaly with mild transaminitis, asplenia, leukocytosis, thrombocytosis, joint pain and features of macrophage activation with negative autoimmune serologies. Lung biopsy revealed cholesterol granulomas. He was found post-mortem by whole exome sequencing to have a compound heterozygous paternal frame shift a paternal frame shift HMOX1 c.264delCTGG (p.L89Sfs*24) and maternal splice donor HMOX1 (c.636+2 T>A) consistent with HMOX1 deficiency. Western blot analysis confirmed lack of HMOX1 protein upon oxidant stimulation of the patient cells. Conclusions: Here, we describe a phenotype expansion for HMOX1-deficiency to include not only asplenia and hepatomegaly, but also interstitial lung disease with cholesterol granulomas and inflammatory flares with hemophagocytosis present in the bone marrow that can mimic systemic-onset juvenile arthritis.
Modeling and optimizing electro-persulfate processes using Fe and Al electrodes for paper industry wastewater treatment
Authors: Varank Gamze , Yazici Guvenc Senem , Demir Ahmet , Kavan Nihal , Donmez Nurten , Onen Zeynep Tugce 
Published: March 2020

Abstract
In this study, the treatment of paper industry wastewaters by the electrocoagulation (EC) process with a strong oxidant, persulfate addition, was investigated. Persulfate was activated by dissolution of Fe and Al from electrodes during the process. Central composite design method, being one of the response surface methods, was applied for the optimization of process parameters and the development of a mathematical model for chemical oxygen demand (COD) removal from paper industry wastewaters. The effects of S2O8−2/COD ratio, current, pH, and reaction time, being the variables of process, were assessed on the efficiency of contaminant removal. For COD removal in EC processes in which Fe and Al electrodes were used, the model's correlation coefficients (R2) were determined as 90.14% and 87.46%, respectively. As the result of experimental study actualized under optimum conditions determined by the model in order to obtain maximum contaminant removal, COD removal efficiencies were determined as 63.5% and 72.8% respectively for the Fe electrode (S2O8−2/COD ratio: 1.25, current: 4.14 A, pH: 6, and reaction time: 5 minutes), and the Al electrode (S2O8−2/COD ratio: 0.5, current: 4.25 A, pH: 7.25, and reaction time: 25 minutes). Electro-activated persulfate process is an appropriate treatment alternative for COD removal from paper industry wastewaters.
Application of surface response method (RSM) to optimize ammonia nitrogen removal from fresh leachate using combination of ultrasound and ultraviolet
Authors: Zarghi Mohammad Hasan , Jaafarzadeh Neamat , Roudbari Aliakbar , Zahedi Amir 
Published: March 2020

Abstract
Ammonia nitrogen levels are very high in leachate. This study was conducted to optimize the removal of ammonia nitrogen from fresh landfill leachate using a combination of ultrasound waves and ultraviolet irradiation. A sample of fresh landfill leachate was obtained from a municipal landfill site, located in Shahroud (Semnan, Iran) and its ammonia nitrogen was measured by spectrophotometric method. Ultrasound and ultraviolet irradiation were simultaneously used to remove ammonia nitrogen. Box–Behnken design (BBD) based on response surface method (RSM) was applied to analyze and optimize ammonia nitrogen removal by different variables, including pH, contact time, ultrasound frequency and UV intensity. Based on this method, 29 samples with three replications were tested. The analysis of variance indicated quadratic model was significant for removal of ammonia nitrogen from leachate. According to the model, 99.7% removal efficiency (%) of ammonia nitrogen was obtained in the optimal conditions (pH at 9.7, contact time of 59.1 min, ultrasound frequency of 54 kHz and UV intensity of 40 W). The removal efficiency of ammonia nitrogen was obtained 98.6% from the laboratory experiment in these conditions, which agrees well with the predicted response value.
A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies
Authors: Li Ying , Liu Chen-Fu , Rao Guo-Wu 
Published: March 2020

Abstract::
Poly (ADP-ribose) polymerase (PARP) acts as an essential DNA repair enzyme.
PARP inhibitors are novel small molecule targeted drugs based on the principle of "Synthetic
Lethality", which affect DNA repair process by competitively inhibiting the activity of PARP
enzyme and thereby kill cancer cells. Currently, four PARP inhibitors including olaparib, rucaparib,
niraparib, and talazoparib have been approved by FDA for cancer treatment and have
achieved great success in the treatment of ovarian cancer, breast cancer, and pancreatic cancer,
etc. This paper provides a general overview of the research progress of PARP inhibitors
including the major structure types, structure-activity relationship (SAR), and synthetic
routes, with the aim of providing ideas for the discovery and synthesis of novel PARP inhibitors.
Effects of Succinic Acid Supplementation on Stable Cell Line Growth, Aggregation, and IgG and IgA Production
Authors: Argentova Victoria , Aliev Teimur , Dolgikh Dmitry , Kirpichnikov Mikhail 
Published: March 2020

Background:
Immunoglobulin (Ig) G is the most commonly used therapeutic antibodies.
Recently, the interest in IgA antibodies to treat respiratory infectious diseases has been
increasing. The reason for the inefficient use of IgA is recombinant antibody aggregation in cell culture,
affecting the longevity and productivity of cell lines. Lactate is an important metabolite that affects
the cultivation of stable cell lines producing monoclonal antibodies.

Methods:
In the present study, we investigated whether different combinations of succinic acid and
micro-additives affect lactate production, which correlates with productivity. The effect of succinic acid
substitution on productivity of cells producing IgG/IgA was analyzed using the static culture method
in a six-well plate. Lactate was measured in supernatant of cell culture indirectly by using the activity
of Lactate Dehydrogenase (LDH).A low lactate level was observed in cultivation medium supplemented
with succinic acid or asparagine combined with some inorganic salts.

Result:
The results also demonstrated the effect of component supplementation on homogeneity, longevity,
and productivity of cell culture. Supplementation of succinic acid eliminated cell aggregation
and improved homogeneity of stable cell lines producing IgG and, especially, IgA.

Conclusion:
Overall, succinic acid supplementation to the culture medium has potential biotechnological
applications in the production IgG and IgA.
A Review on the Current Methods of Chinese Hamster Ovary (CHO) Cells Cultivation for the Production of Therapeutic Protein
Authors: Sharker Shazid Md. , Rahman Atiqur 
Published: March 2020

:
Most of the clinical approved protein-based drugs or under clinical trials have a profound
impact on the treatment of critical diseases. The mammalian eukaryotic cells culture approaches,
particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical
industry for the mass-production of the therapeutic protein. Recent advances in CHO cell
bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression
of quality protein. The developments of cell lines are possible to enhance specific productivity.
As a result, it holds an interesting area for academic as well as industrial researchers around the
world. This review will focus on the recent progress of the mammalian CHO cells culture technology
and the future scope of further development for the mass-production of protein therapeutics.
Concurrent Methicillin-Resistant Staphylococcus aureus Septicemia and Thyroid Abscess in a Young Male with Dengue
Authors: Meena Durga Shankar , Kumar Deepak , Bohra Gopal Krishana , Garg Mahendra kumar , Midha Naresh , Yadav Taruna , Yadav Prakrati 
Published: March 2020

Background:Dengue fever is an arthropod-borne viral infection with a very high incidence rate in Southeast Asia. Most patients present with self-limiting febrile illness, while some patients may develop complications like acute kidney injury, acute liver failure, myocarditis or Guillain– Barre syndrome. The coexistence of Dengue and MRSA (Methicillin-resistant Staphylococcus aureus ) is rarely reported in the literature.Case:A 28-year-old male is presented with high-grade fever, polyserositis and thrombocytopenia. The patient was treated symptomatically for dengue infection. During the course of hospitalization, patient developed neck swelling (thyroid abscess) and left forearm abscess. MRSA was isolated from blood culture and pus, and successfully treated with iv antibiotics (Vancomycin).Conclusion:High anticipation and vigilance are required to detect concurrent bacteremia in dengue patients. Early recognition of warning signs with readily antibiotic therapy is important to prevent mortality and morbidity in these patients. Our report also highlights the MRSA as a rare cause of thyroid abscess, with only 5 cases reported in the literature so far.
Rare Itemsets Selector with Association Rules for Revenue Analysis by Association Rare Itemset Rule Mining Approach
Authors: Selvarani S. , Jeyakarthic M. 
Published: March 2020

Background:
Knowledge discovering rare itemsets mining, and association rules are
significant in a transactional dataset. Be that as it may, rare association rules are now and again
more intriguing than frequent association rules since rare rules indicate an unforeseen or obscure
association. The utilization of rare itemsets mining with item selector is unavoidable and has
turned into an emerging field of research; therefore, this subject has numerous challenges.

Objective:
To perform the revenue examination of the marketing sector by rare itemsets selector by
threshold and time series-based prediction technique.

Methods:
This paper gives the revenue examination of marketing sector by rare itemsets selector by threshold and time series-based prediction technique. A new algorithm for locating the rare itemsets by Association Rare itemset Rule Mining (ARIRM) to produced rules then utility itemsets discover by the threshold. When the rare patterns are analyzed, the ARIMA model used to anticipate the revenue. Based on the investigation of rare showcasing data with rules of the mining space, this methodology uses a tree structure to learn the rare items.

Results:
The test results in the "K" transactions with high revenues discovered utilizing the proposed
model contrasted with other existing procedures; this forecast procedure is helpful for upcoming
transactions.

Conclusion:
Based on the investigation of rare showcasing data with rules of the mining space, this methodology uses a tree structure to learn the rare items.
Cost-Effective Cluster-Based Energy Efficient Routing for Green Wireless Sensor Network
Authors: Verma Sandeep , Sood Neetu , Sharma Ajay K. 
Published: March 2020

Background:
The green Information and Communications Technologies (ICTs) have brought a revolution in uplifting the technology efficiently to facilitate human sector in the best possible way. Green Wireless Sensor Network (WSN) tactically focuses on improving the survival period of deployed nodes (as they have limited battery) in any target area.

Objectives:
To address this concern, the main objective is to improve the routing in WSN. The cluster-
based routing helps in acquiring the same with the appropriate Cluster Head (CH) selection.
The use of energy heterogeneous nodes that normally comprise of high energy nodes, puts a lot of
financial burden on the users as they incur a huge cost, thus becoming a bottleneck for the growth
of green WSN. Therefore , another objective of the study is to reduce this cost involved in the network.

Method:
A cost-effective routing protocol is proposed that introduces energy-efficient CH selection
by incorporating parameters namely, node density, residual energy, the total energy of network
and distance factor. Thus, the proposed protocol is termed as Cost-Effective Cluster-based
Routing Protocol (CECRP) as it performs remarkably better with only two energy level nodes as
compared to state-of-the-art protocols with three levels nodes.

Results:
It can be encapsulated from the simulation results that CECRP outperforms state-of-theprotocols
on different performance metrics.

Conclusion:
Furthermore, it is comprehended from the simulation results that CECRP proves to be
33.33% more cost-effective as compared to the competent protocols, hence CECRP favors the
green WSN.
PECULIARITIES OF COMPLEX REHABILITATION OF PATIENTS WITH MOTOR AND COGNITIVE IMPAIRMENTS AFTER A HEMISPHERIC ISCHEMIC STROKE
Authors: Pulyk O. R. , Hyryavets M. V. 
Published: March 2020

Purpose: Improve the recovery of the motor function of the hand in patients with cognitive impairment after a hemispheric ischemic stroke by using unilateral mirror therapy.
Materials and Methods: The study was conducted at the department of vascular neurology Uzhgorod central city hospital for six months of 2018. All patients underwent general clinical examination, neuroimaging examination, neuropsychological examination using a battery of tests, functional examination using Scandinavian Stroke Study Group Scale and The Modified Ashworth Scale, Scale for assessing muscle strength (Peak L. M. and Braddom R.), Hospital anxiety and depression scale, Modified Rankin Scale. Unilateral mirror therapy was carried out 3 times a week twice a day for 15 minutes, initially on the basis of the department further outpatient for 2 months.
Results: The study involved 56 patients, residents of Uzhgorod, have suffered hemispheric ischemic stroke. At the end of the treatment, the Scandinavian Scale of Stroke Scale Improvement Therapy and the muscle strength score were observed in patients in both groups; in the main group, the median score was significantly higher. The muscle strength score also showed improvement in both groups, but the arm function was probably better recovered in the group of patients using mirror therapy. After rehabilitation, muscle tone diminished in both groups, no significant differences were observed. The probable improvement of cognitive function in the main group, vizual-spatial, peripheral-visual perception and the speed of mental reactions was revealed. At the same time, reduction of depression in patients of both groups was established.
Conclusions: the involvement of unilateral mirror therapy in the rehabilitation of patients with motor and cognitive impairment after a hemispheric ischemic stroke improves the motor function of the arm
Integrating Health Technologies in Health Services for Syrian Refugees in Lebanon: Qualitative Study
Authors: Talhouk Reem , Akik Chaza , Araujo-Soares Vera , Ahmad Balsam , Mesmar Sandra , Olivier Patrick , Balaam Madeline , Montague Kyle , Garbett Andrew , Ghattas Hala 
Published: March 2020

Background
Lebanon currently hosts around one million Syrian refugees. There has been an increasing interest in integrating eHealth and mHealth technologies into the provision of primary health care to refugees and Lebanese citizens.

Objective
We aimed to gain a deeper understanding of the potential for technology integration in primary health care provision in the context of the protracted Syrian refugee crisis in Lebanon.

Methods
A total of 17 face-to-face semistructured interviews were conducted with key informants (n=8) and health care providers (n=9) involved in the provision of health care to the Syrian refugee population in Lebanon. Interviews were audio recorded and directly translated and transcribed from Arabic to English. Thematic analysis was conducted.

Results
Study participants indicated that varying resources, primarily time and the availability of technologies at primary health care centers, were the main challenges for integrating technologies for the provision of health care services for refugees. This challenge is compounded by refugees being viewed by participants as a mobile population thus making primary health care centers less willing to invest in refugee health technologies. Lastly, participant views regarding the health and technology literacies of refugees varied and that was considered to be a challenge that needs to be addressed for the successful integration of refugee health technologies.

Conclusions
Our findings indicate that in the context of integrating technology into the provision of health care for refugees in a low or middle income country such as Lebanon, some barriers for technology integration related to the availability of resources are similar to those found elsewhere. However, we identified participant views of refugees’ health and technology literacies to be a challenge specific to the context of this refugee crisis. These challenges need to be addressed when considering refugee health technologies. This could be done by increasing the visibility of refugee capabilities and configuring refugee health technologies so that they may create spaces in which refugees are empowered within the health care system and can work toward debunking the views discovered in this study.
Information Loss in Harmonizing Granular Race and Ethnicity Data: Descriptive Study of Standards
Authors: Wang Karen , Grossetta Nardini Holly , Post Lori , Edwards Todd , Nunez-Smith Marcella , Brandt Cynthia 
Published: March 2020

Background
Data standards for race and ethnicity have significant implications for health equity research.

Objective
We aim to describe a challenge encountered when working with a multiple–race and ethnicity assessment in the Eastern Caribbean Health Outcomes Research Network (ECHORN), a research collaborative of Barbados, Puerto Rico, Trinidad and Tobago, and the US Virgin Islands.

Methods
We examined the data standards guiding harmonization of race and ethnicity data for multiracial and multiethnic populations, using the Office of Management and Budget (OMB) Statistical Policy Directive No. 15.

Results
Of 1211 participants in the ECHORN cohort study, 901 (74.40%) selected 1 racial category. Of those that selected 1 category, 13.0% (117/901) selected Caribbean; 6.4% (58/901), Puerto Rican or Boricua; and 13.5% (122/901), the mixed or multiracial category. A total of 17.84% (216/1211) of participants selected 2 or more categories, with 15.19% (184/1211) selecting 2 categories and 2.64% (32/1211) selecting 3 or more categories. With aggregation of ECHORN data into OMB categories, 27.91% (338/1211) of the participants can be placed in the “more than one race” category.

Conclusions
This analysis exposes the fundamental informatics challenges that current race and ethnicity data standards present to meaningful collection, organization, and dissemination of granular data about subgroup populations in diverse and marginalized communities. Current standards should reflect the science of measuring race and ethnicity and the need for multidisciplinary teams to improve evolving standards throughout the data life cycle.
...de mitos y cuentos de hadas
Authors: Steenbock Mónica 
Published: March 2020

La magia inherente a ogros, duendes y princesas ha fascinado al hombre desde tiempos inmemoriales. De ella se nutren tanto los cuentos de hadas como las narraciones míticas. Entre la ficción y la realidad, tanto mitos como cuentos forman parte de un ámbito imaginario, paralelo al mundo de lo cotidiano, en el que la condición de lo primigenio se reinstaura a través del relato y define en gran medida nuestra vida afectiva. Sin embargo, a diferencia del mito que se vincula a una religiosidad sujeta a las dinámicas de poder, el cuento de hadas pertenece a la esfera de lo secular y puede, por lo tanto, sustraerse al rigor impuesto por la autoridad. Cabe decir que, durante el siglo XVI, los cuentos coloquiales fueron rescatados de la tradición oral y se convirtieron en un fenómeno literario que se erige como antecedente de los Contes de Feés de la aristocracia francesa del siglo XVII y de los Märchen alemanes de los siglos XVIII y XIX.
Identidad, tiempo y espacio en El tornavoz de Jesús Gardea
Authors: Tornero Salinas Angélica 
Published: March 2020

En este artículo se explora la relación entre tiempo, espacio e identidad en El tornavoz de Jesús Gardea. El objetivo es observar cómo se entrecruzan el espacio y el tiempo y cómo esta relación se resuelve en la configuración de la identidad de los personajes. La reflexión se realiza en dos dimensiones, a partir del análisis de las estructuras del texto y de la hermenéutica.
De la nostalgia a la invención: Seva. Invasión de Estados Unidos a Puerto Rico
Authors: Berecochea Ximena 
Published: March 2020

En el ensayo titulado “De la nostalgia a la invención: Seva”, se aborda Seva. Historia de la primera invasión norteamericana de la isla de Puerto Rico ocurrida en mayo de 1898, del autor puertorriqueño Luis López Nieves, desde dos perspectivas. La primera se relaciona con el impulso nostálgico que la hace posible, y la segunda con la forma en la que el autor refuerza el contenido, que al parecer funciona como un paliativo a su añoranza. La respuesta del público, se explica, muestra la continuación del sentimiento nostálgico del autor en los lectores. Ciertamente, el efecto de la primera publicación fue definido por la historia común entre autor y lector. Sin embargo, se hace una exposición crítica de los distintos modos de significar que el autor utilizó para configurar el carácter verdadero de su propio y compartido mundo idílico.
Cuando calla Sherezada: elogio del cliffhanger y los "finales" femeninos
Authors: González Treviño Ana Elena 
Published: March 2020

En este artículo se explora el significado del silencio como estrategia narrativa con referencia especial a Las mil y una noches. Según Foucault, en el contexto académico patriarcal, el discurso es la norma, aunque sea violento y excluyente, mientras que guardar silencio resulta antiético y débil. Por el contrario, el silencio femenino es una especie de norma implícita en diversos contextos culturales. Sin embargo, Sherezada utiliza el silencio estratégicamente y lo convierte en un poder a través de la suspensión deliberada de la narración. Si esta acción se extrapola al ámbito literario y cultural en general, se observa que, como ejemplo típico, novelas y telenovelas posponen los finales de un modo análogo en una especie de seducci´ón que se ha explotado e interpretado repetidamente.