bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disease Characteristics and Severity in Patients With Inflammatory Bowel Disease With Coexistent Diabetes Mellitus
Authors: Din Hassieb , Anderson Alyce J , Ramos Rivers Claudia , Proksell Siobhan , Koutroumpakis Filippos , Salim Tariq , Babichenko Dmitriy , Tang Gong , Koutroubakis Ioannis E , Schwartz Marc , Johnston Elyse , Barrie Arthur , Harrison Janet , Hashash Jana , Dunn Michael A , Hartman Douglas J , Binion David G 
Published: January 2020

Abstract

Background
Given the rising prevalence of diabetes mellitus (DM) and the limited data on its effect on the course of inflammatory bowel disease (IBD), we characterized multiyear patterns of disease severity in a cohort of IBD patients with coexistent DM.

Methods
Data of consented IBD patients followed prospectively in a natural history registry at a tertiary center between 2009 and 2017 were analyzed. Patients with ≥3 years of clinical follow-up were included. Patients identified with a diagnosis of DM were compared with 400 consecutive IBD controls without a diagnosis of DM, no laboratory evidence of hyperglycemia, and no history of antihyperglycemic treatment.

Results
Out of 2810 IBD patients, 141 (5%) had DM (IBD DM; 44% ulcerative colitis, 56% Crohn’s disease, 48.2% female). IBD DM had higher use of 5-aminosalicylic acid (5ASA) agents (P = 0.04), narcotics (P &lt; 0.001), and antibiotics (P = 0.007) but not immunomodulators and/or biologics compared with IBD controls. When analyzing biomarkers of severity, IBD DM demonstrated higher frequencies of elevated C-reactive protein (CRP; P = 0.006), elevated erythrocyte sedimentation rate (ESR; P = 0.001), eosinophilia (P = 0.004), monocytosis (P = 0.02), and hypoalbuminemia (P = 0.001). IBD DM had worse quality of life (mean Short Inflammatory Bowel Disease Questionnaire; P &lt; 0.001). IBD DM had increased health care utilization compared with controls (emergency room usage P = 0.008, hospitalizations P &lt; 0.001, gastroenterology clinic visits P &lt; 0.001, and median annual charges P &lt; 0.001). Among IBD DM patients, the use of immunomodulators and/or biologics was not associated with further complications as measured by antibiotic use or hospitalizations.

Conclusions
This study of a large IBD cohort suggests that DM in IBD may be associated with increased disease severity and that there may be room for increasing use of highly effective immunomodulator and/or biologic agents in this group.
Anthropogenic Change Alters Ecological Relationships via Interactive Changes in Stress Physiology and Behavior within and among Organisms
Authors: Hammond Talisin T , Ortiz-Jimenez Chelsea A , Smith Jennifer E 
Published: January 2020

Synopsis
Anthropogenic change has well-documented impacts on stress physiology and behavior across diverse taxonomic groups. Within individual organisms, physiological and behavioral traits often covary at proximate and ultimate timescales. In the context of global change, this means that impacts on physiology can have downstream impacts on behavior, and vice versa. Because all organisms interact with members of their own species and other species within their communities, the effects of humans on one organism can impose indirect effects on one or more other organisms, resulting in cascading effects across interaction networks. Human-induced changes in the stress physiology of one species and the downstream impacts on behavior can therefore interact with the physiological and behavioral responses of other organisms to alter emergent ecological phenomena. Here, we highlight three scenarios in which the stress physiology and behavior of individuals on different sides of an ecological relationship are interactively impacted by anthropogenic change. We discuss host–parasite/pathogen dynamics, predator–prey relationships, and beneficial partnerships (mutualisms and cooperation) in this framework, considering cases in which the effect of stressors on each type of network may be attenuated or enhanced by interactive changes in behavior and physiology. These examples shed light on the ways that stressors imposed at the level of one individual can impact ecological relationships to trigger downstream consequences for behavioral and ecological dynamics. Ultimately, changes in stress physiology on one or both sides of an ecological interaction can mediate higher-level population and community changes due in part to their cascading impacts on behavior. This framework may prove useful for anticipating and potentially mitigating previously underappreciated ecological responses to anthropogenic perturbations in a rapidly changing world.
Del Nido cardioplegia in coronary surgery: a propensity-matched analysis
Authors: Schutz Alexander , Zhang Qianzi , Bertapelle Kimberly , Beecher Nicholas , Long William , Lee Vei-Vei , Pan Wei , Arcaro Michael , Ghanta Ravi , Jimenez Ernesto , Ott David A , Loor Gabriel 
Published: January 2020

AbstractOBJECTIVESDel Nido cardioplegia (DNC) has been shown to be safe in adults with normal coronary arteries who are undergoing valve surgery. This study compared the effects of DNC versus traditional blood-based cardioplegia on postoperative complications in patients who underwent coronary artery bypass grafting (CABG).METHODSA retrospective analysis was performed on 863 patients who underwent CABG with DNC (n = 420) or control cardioplegia (CC) (n = 443) between 2014 and 2017. The full cohort of DNC and CC recipients, as well as propensity score-matched pairs, was compared regarding preoperative risk variables and outcomes.RESULTSThe DNC and CC groups showed no significant differences in mean cardiopulmonary bypass time (53.09 vs 52.10 min, P = 0.206) or aortic cross-clamp time (32.82 vs 33.28 min, P = 0.967). The groups also showed no difference in operative mortality (2.1% vs 2.5%, P = 0.734); however, DNC use resulted in lower rates of overall infections (1.7% vs 4.3%, P = 0.024), total sternal infections (0.9% vs 3.2%, P = 0.023), postoperative atrial fibrillation (23.8% vs 30.7%, P = 0.023) and postoperative ventricular tachycardia (0.5% vs 3.4%, P = 0.002). A propensity-matching analysis (n = 335 pairs) showed similar statistically significant decreases with DNC.CONCLUSIONSIn this large cohort of CABG patients, DNC was shown as a safe alternative to CC and was associated with lower postoperative dysrhythmia and infection rates. These findings show that DNC is safe and effective in patients whose operative interventions may require only single-dosing cardioplegia; its use in longer cases should be further explored given its low complication rate.
Human Immunodeficiency Virus and Hepatitis C Virus Infection Testing Among Commercially Insured Persons Who Inject Drugs, United States, 2010–2017
Authors: Bull-Otterson Lara , Huang Ya-Lin A , Zhu Weiming , King Hope , Edlin Brian R , Hoover Karen W 
Published: January 2020

AbstractBackgroundWe assessed prevalence of testing for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection among persons who inject drugs (PWID).MethodsUsing a nationwide health insurance database for claims paid during 2010–2017, we identified PWID by using codes from the International Classification of Diseases, Current Procedural Terminology, and National Drug Codes directory. We then estimated the percentage of PWIDs tested for HIV or HCV within 1 year of an index encounter, and we used multivariate logistic regression models to assess demographic and clinical factors associated with testing.ResultsOf 844 242 PWIDs, 71 938 (8.5%) were tested for HIV and 65 188 (7.7%) were tested for HCV infections. Missed opportunities were independently associated with being male (odds ratios [ORs]: HIV, 0.50 [95% confidence interval {CI}, 0.49–0.50], P &lt; .001; HCV, 0.66 [95% CI, 0.65–0.72], P &lt; .001), rural residence (ORs: HIV, 0.67 [95% CI, 0.65–0.69], P &lt; .001; HCV, 0.75 [95% CI, 0.73–0.77], P &lt; .001), and receiving services for skin infections or endocarditis (adjusted ORs: HIV, 0.91 [95% CI, 0.87–0.95], P &lt; .001; HCV, 0.90 [95% CI, 0.86–0.95], P &lt; .001).ConclusionsApproximately 90% of presumed PWIDs missed opportunities for HIV or HCV testing, especially male rural residents with claims for skin infections or endocarditis, commonly associated with injection drug use.
Humoral and Mucosal Immune Responses to Human Norovirus in the Elderly
Authors: Costantini Veronica P , Cooper Emilie M , Hardaker Hope L , Lee Lore E , DeBess Emilio E , Cieslak Paul R , Hall Aron J , Vinjé Jan 
Published: January 2020

Abstract

Background
Most information on mucosal and systemic immune response to norovirus infection is derived from human challenge studies, birth cohort studies, or vaccine trials in healthy adults. However, few data are available on immune responses to norovirus in the elderly.

Methods
To study the mucosal and systemic immune response against norovirus, 43 long-term care facilities were enrolled prospectively in 2010–2014. Baseline saliva samples from 17 facilities, cases and controls up to day 84 from 10 outbreaks, as well as acute and convalescent sera were collected.

Results
Norovirus-specific immunoglobulin A (IgA) levels in baseline saliva samples were low and increased in both symptomatic patients and asymptomatic shedders at day 5 after onset during outbreaks. Receiver operating characteristics analysis correctly assigned prior norovirus infection in 23 (92%) of 25 participants. Cases and asymptomatic shedders showed seroconversion for IgG (80%), IgA (78%), and blockade antibodies (87%). Salivary IgA levels strongly correlated with increased convalescent serum IgA titers and blockade antibodies.

Conclusions
Salivary IgA levels strongly correlated with serum IgA titers and blockade antibodies and remained elevated 3 months after a norovirus outbreak. A single salivary sample collected on day 14 could be used to identify recent infection in a suspected outbreak or to monitor population salivary IgA.
Systematic Review: Patient Perceptions of Monitoring Tools in Inflammatory Bowel Disease
Authors: Goodsall Thomas M , Noy Richard , Nguyen Tran M , Costello Samuel P , Jairath Vipul , Bryant Robert V 
Published: January 2020

Abstract

Background and Aims
Inflammatory bowel disease (IBD) is a lifelong disease requiring frequent assessment to guide treatment and prevent flares or progression. Multiple tools are available for clinicians to monitor disease activity; however, there are a paucity of data to inform which monitoring tools are most acceptable to patients. The review aims to describe the available evidence for patient preference, satisfaction, tolerance and/or acceptability of the available monitoring tools in adults with IBD.

Methods
Embase, Medline, Cochrane Central and Clinical Trials.gov were searched from January 1980 to April 2019 for all study types reporting on the perspectives of adults with confirmed IBD on monitoring tools, where two or more tools were compared. Outcome measures with summary and descriptive data were presented.

Results
In 10 studies evaluating 1846 participants, monitoring tools included venipuncture, stool collection, gastrointestinal ultrasound, computed tomography, magnetic resonance imaging, wireless capsule endoscopy, barium follow-through and endoscopy. Outcome domains were patient satisfaction, acceptability of monitoring tool and patient preference. Noninvasive investigations were preferable to endoscopy in nine studies. When assessed, gastrointestinal ultrasound was consistently associated with greater acceptability and satisfaction compared with endoscopy or other imaging modalities.

Conclusions
Adults with IBD preferred noninvasive investigations, in particular gastrointestinal ultrasound, as compared to endoscopy for monitoring disease activity. When assessing disease activity, patient perceptions should be considered in the selection of monitoring tools. Further research should address whether adpoting monitoring approaches considered more acceptable to patients results in greater satisfaction, adherence and ultimately more beneficial clinical outcomes.
Burial and Compaction of Sandy Soils to Prevent Emergence of Adult Stable Fly (Diptera: Muscidae) at the Soil Surface
Authors: Cook David Francis , Deyl Robert A , Lindsey Jeremy B , D’Antuono Mario F , Telfer Donald V , McPharlin Ian R 
Published: January 2020

Abstract
Stable fly (Stomoxys calcitrans L.) remain a significant pest affecting livestock and rural communities on the Swan Coastal Plain around Perth, Western Australia. Vegetable crop residues remaining after harvest enable stable fly development. Left untreated they can produce from several hundred to &gt;1,000 stable fly/m2 of post-harvest residues. We studied the effect of burial and compaction of sandy soils on adult emergence of stable fly and house fly (Musca domestica L.) (Diptera: Muscidae). Adults of both fly species can move up through 50 cm of loose, dry sand, however at depths greater than 60 cm, emergence rapidly declines with &lt;5% of adults surviving under 100 cm of soil. Burial of stable fly larvae and pupae under 15 cm of soil followed by compaction using a static weight dramatically reduced adult emergence. Moist soil compacted at ≥3 t/m2 completely prevented stable fly emergence whereas house fly emergence was not affected. One t/m2 of compaction resulted in &lt;5% emergence of stable fly buried as pupae. Soil that was easily compactible (i.e., high silt, fine sand and clay content) reduced stable fly emergence more than soil with more coarse sand and low clay content. This study demonstrates the potential for a novel and chemical-free option for controlling stable fly development from vegetable crop post-harvest residue. Field trials are needed to confirm that burial and compaction of vegetable post-harvest residues using agricultural machinery can dramatically reduce the subsequent emergence of adult stable fly on a large scale.
Calcium channel CNGC19 mediates basal defense signaling to regulate colonization by Piriformospora indica in Arabidopsis roots
Authors: Jogawat Abhimanyu , Meena Mukesh Kumar , Kundu Anish , Varma Mahendra , Vadassery Jyothilakshmi 
Published: January 2020

Abstract
The activation of calcium signaling is a crucial event for perceiving environmental stress. Colonization by Piriformospora indica, a growth-promoting root endosymbiont, activates cytosolic Ca2+ in Arabidopsis roots. In this study, we examined the role and functional relevance of calcium channels responsible for Ca2+ fluxes. Expression profiling revealed that CYCLIC NUCLEOTIDE GATED CHANNEL 19 (CNGC19) is an early-activated gene, induced by unidentified components in P. indica cell-wall extract. Functional analysis showed that loss-of-function of CNGC19 resulted in growth inhibition by P.indica, due to increased colonization and loss of controlled fungal growth. The cngc19 mutant showed reduced elevation of cytosolic Ca2+ in response to P. indica cell-wall extract in comparison to the wild-type. Microbe-associated molecular pattern-triggered immunity was compromised in the cngc19 lines, as evidenced by unaltered callose deposition, reduced cis-(+)-12-oxo-phytodienoic acid, jasmonate, and jasmonoyl isoleucine levels, and down-regulation of jasmonate and other defense-related genes, which contributed to a shift towards a pathogenic response. Loss-of-function of CNGC19 resulted in an inability to modulate indole glucosinolate content during P. indica colonization. CNGC19-mediated basal immunity was dependent on the AtPep receptor, PEPR. CNGC19 was also crucial for P. indica-mediated suppression of AtPep-induced immunity. Our results thus demonstrate that Arabidopsis CNGC19 is an important Ca2+ channel that maintains a robust innate immunity and is crucial for growth-promotion signaling upon colonization by P. indica.
Simulation of the loss-cone instability in spherical systems – II. Dominating Keplerian potential
Authors: Polyachenko E V , Berczik P , Just A , Shukhman I G 
Published: January 2020

ABSTRACT
According to our previous theoretical findings, physical processes in centres of galaxies, star clusters, and the Oort comet cloud can be significantly altered by a new so-called ‘gravitational loss-cone instability’. Using N-body simulations of a spherical stellar model in the dominating Keplerian potential, we confirm the possibility of the instability and go beyond the linear theory. Unlike most other instabilities, the new one shows no notable change in spherical geometry of the cluster, but it significantly accelerates the speed of diffusion of particles in phase space leading to a repopulation of the loss cone and early instability saturation.
Ethics in Music Therapy Education: Four Points to Consider
Authors: DiMaio Lauren , Engen Becky 
Published: January 2020

Abstract
Ethical thinking in music therapy is a vital aspect of the profession. However, little is published on the subject of ethics in the music therapy academic setting. Therefore, this article explores the complex issues of ethics and ethical thinking in music therapy education from the perspective of two music therapists who have held various positions within academics in music therapy. The purpose of this article is to encourage integrity within music therapy education and to draw attention to the complex ethical issues within music therapy academics. Four points are described for music therapy educators: (1) Assess positions of power, (2) Explore your adaptability, (3) Assess possible infringement of rights, and (4) Consider cultural bias in your responses. These points are offered as recommendations inserted into the Dileo Model of Ethical Thinking for Music Therapists for people in academia when faced with ethical dilemmas.
An overview of frailty in kidney transplantation: measurement, management and future considerations
Authors: Harhay Meera N , Rao Maya K , Woodside Kenneth J , Johansen Kirsten L , Lentine Krista L , Tullius Stefan G , Parsons Ronald F , Alhamad Tarek , Berger Joseph , Cheng XingXing S , Lappin Jaqueline , Lynch Raymond , Parajuli Sandesh , Tan Jane C , Segev Dorry L , Kaplan Bruce , Kobashigawa Jon , Dadhania Darshana M , McAdams-DeMarco Mara A 
Published: January 2020

AbstractThe construct of frailty was first developed in gerontology to help identify older adults with increased vulnerability when confronted with a health stressor. This article is a review of studies in which frailty has been applied to pre- and post-kidney transplantation (KT) populations. Although KT is the optimal treatment for end-stage kidney disease (ESKD), KT candidates often must overcome numerous health challenges associated with ESKD before receiving KT. After KT, the impacts of surgery and immunosuppression represent additional health stressors that disproportionately impact individuals with frailty. Frailty metrics could improve the ability to identify KT candidates and recipients at risk for adverse health outcomes and those who could potentially benefit from interventions to improve their frail status. The Physical Frailty Phenotype (PFP) is the most commonly used frailty metric in ESKD research, and KT recipients who are frail at KT (~20% of recipients) are twice as likely to die as nonfrail recipients. In addition to the PFP, many other metrics are currently used to assess pre- and post-KT vulnerability in research and clinical practice, underscoring the need for a disease-specific frailty metric that can be used to monitor KT candidates and recipients. Although frailty is an independent risk factor for post-transplant adverse outcomes, it is not factored into the current transplant program risk-adjustment equations. Future studies are needed to explore pre- and post-KT interventions to improve or prevent frailty.
Extreme Lateral Transodontoid Approach for Resection of Clival Chordoma: 2-Dimensional Operative Video
Authors: Joyce Evan J , Cohen Michael A , Ho Winson , Brockmeyer Douglas L , Couldwell William T 
Published: January 2020

Abstract
This 15-yr-old girl presented with nasal obstruction and dysphagia of duration 3 mo and 8 to 10 pounds of weight loss. On examination, she had a hoarse voice and left tongue deviation without weakness or myelopathy. Computed tomography (CT) demonstrated an erosive lesion arising from the clivus and left occipital condyle. Magnetic resonance imaging (MRI) demonstrated a T1-isointense, T2-hyperintense, enhancing mass centered at the occipital condyle and extending into the craniovertebral junction (CVJ), causing severe brainstem compression and extending inferiorly to C2 and anteriorly into the retropharyngeal space. The patient underwent transoral biopsy to confirm the diagnosis of chordoma and complete tumor resection via a left extreme lateral transodontoid (ELTO) approach. This approach was chosen because it provides bilateral exposure to the ventral CVJ and retropharyngeal space and allows for complete tumor removal using a single approach, although it requires an experienced surgeon. The ELTO incision should provide adequate exposure for occipitocervical fusion (OCF) after the destabilization of the CVJ. Transposition of the vertebral artery and odontoidectomy are key maneuvers that provide exposure to the ventral CVJ bilaterally. Dural closure is performed primarily and augmented with fat, fibrin glue, and temporary cerebrospinal fluid diversion. Postoperative MRI showed a gross-total resection and decompression of the brainstem at the CVJ. The patient remained in a cervical collar until OCF. Postoperatively, she had left vocal cord paralysis and moderate weakness with left arm abduction at the deltoid. At 2-mo follow-up, she had improved lower cranial neuropathies, tolerated oral intake, and was scheduled to begin proton beam therapy. The patient provided consent for publication.
Constructing Allyship and the Persistence of Inequality
Authors: Sumerau J E , Forbes TehQuin D , Denise Eric Joy , Mathers Lain A B 
Published: January 2020

AbstractWe examine how people construct what it means to be an ally to marginalized groups. Based on 70 in-depth interviews with college students who identify as allies to one or more marginalized groups, we analyze how they construct allyship in ways that ultimately reproduce patterns of social inequality by (1) assigning responsibility for inequalities to minorities, and (2) suggesting individualized, rather than structural, remedies for combatting unequal systems. We find that the combination of these strategies allows them to claim identities as allies without having to engage in concrete efforts that could challenge systems of oppression. We argue that systematically examining processes through which people construct and perform what it means to be an ally may provide insights into mechanisms whereby inequality is maintained and justified. Such systematic examination may also point to potential avenues for combating social inequalities.