bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of PM2.5 on macrosomia in China: A nationwide prospective cohort study
Authors: Chen Shi , Wang Shirui , Li Tiantian , Zhu Huijuan , Liang Siyu , Xu Ke , Zhang Yuelun , Yuan Xianxian , Yang Yingying , Pan Hui , Shi Xiaoming 
Published: November 2019

SummaryBackgroundMacrosomia is associated with both neonatal complications and adult diseases (obesity, diabetes mellitus, etc.). Previous studies have reported maternal exposure to PM2.5 might influence metabolism and fetal development and cause adverse pregnancy outcomes. Studies conducted in areas with low PM2.5 concentration have found relationship between gestational PM2.5 exposure and birth weight. However, the impact of air pollution on macrosomia has not been studied, especially in highly polluted areas.ObjectiveTo evaluate the association between fine particulate matter (PM2.5) exposure during pregnancy and the risk of macrosomia.MethodsData from preconception health examination and prenatal and postnatal records were collected from 1 January 2010 to 31 December 2012 in the National Free Preconception Health Examination Project. Monthly mean of PM2.5 concentration during pregnancy was estimated from satellite data using an ensemble machine learning model. A newborn with birth weight above 4000 g was defined as macrosomia. Logistic regression models were used to examine the association between maternal exposure to PM2.5 and the risk of macrosomia, after adjusting for maternal age, pre‐pregnancy body mass index, parity, neonatal sex, duration of gestation, seasonality, educational level, smoking and drinking habits, past history of diabetes mellitus and hypertension, and family history of diabetes mellitus. Restricted cubic spline models were used to evaluate the dose‐response relationship between the risk of macrosomia and PM2.5 concentration.ResultsOf 177 841 singleton nonlow birth weight newborns included, 14 598 (8.2%) had macrosomia. The mean PM2.5 concentrations were 70.7, 71.5, and 80.9 μg/m3 in the first, second, and third trimesters. In full‐adjusted logistic regression models, significant associations were found between increased risk of macrosomia and every 10 μg/m3 increase of PM2.5 concentration over the first (odds ratio [OR]: 1.045; 95% CI, 1.037‐1.052), second (OR: 1.035; 95% CI, 1.028‐1.043), and third (OR: 1.033; 95% CI, 1.026‐1.039) trimesters. There was a nonlinear does‐response association between PM2.5 concentration and the risk of macrosomia.ConclusionsMaternal exposure to PM2.5 during pregnancy was associated with an increased risk of macrosomia in China.
Childhood hair cortisol concentration and early teen cardiometabolic outcomes
Authors: Petimar Joshua , Rifas‐Shiman Sheryl L. , Hivert Marie‐France , Fleisch Abby F. , Tiemeier Henning , Oken Emily 
Published: November 2019

SummaryObjectiveTo examine associations of hair cortisol concentration (HCC) in mid‐childhood and change in HCC from mid‐childhood to early adolescence (ΔHCC) with early adolescent adiposity and cardiometabolic biomarker measures.MethodsIn Project Viva, a pre‐birth cohort of mothers and children, we measured HCC in 599 white children in mid‐childhood and in 426 of these participants in early adolescence. We used multivariable linear regression to examine associations of mid‐childhood HCC and ΔHCC with BMI‐for‐age‐and‐sex z score, waist circumference, waist‐height ratio, dual X‐ray absorptiometry total and trunk fat mass, a metabolic risk z score, adiponectin, HOMA‐IR, high‐density lipoprotein, C‐reactive protein, interleukin‐6, leptin, and systolic blood pressure.ResultsOver a mean (SD) follow‐up of 5.2 (0.8) years, we did not find associations of mid‐childhood HCC with BMI‐for‐age‐and‐sex z score (β = 0.00 per 1‐interquartile range of HCC, 95% confidence interval [CI], −0.08 to 0.07), waist circumference (β = −0.04 cm, 95% CI, −0.83 to 0.74), metabolic risk z score (β = 0.04, 95% CI, −0.03 to 0.11), or other cardiometabolic measures except for an increase in log‐transformed HOMA‐IR (β = 0.10, 95% CI, 0.04‐0.17). ΔHCC was not associated with any outcome measures.ConclusionsWe found that mid‐childhood HCC was not associated with early adolescent adiposity or cardiometabolic biomarkers except for a slight increase in HOMA‐IR.
Smart energy pricing for demand‐side management in renewable energy smart grids
Authors: Borges Yulle G. F. , Schouery Rafael C. S. , Miyazawa Flávio K. , Granelli Fabrizio , da Fonseca Nelson L. S. , Melo Lucas P. 
Published: November 2019

AbstractSmart grids are expected to provide various benefits to society by integrating advances in power engineering with recent developments in the field of information and communications technology. One of the advantages is the support to efficient demand‐side management (DSM), for example, changes in consumer demands for energy based on using incentives. Indeed, DSM is expected to help grid operators balance time‐varying generation by wind and solar units, and the optimization of their usage. This paper focuses on DSM considering renewable energy generation and proposes an auction, in which consumers submit bids to renewable energy usage plans. An additional model is introduced to allow consumers to compute their bid for a given usage plan. Both models have been extended to include energy storage devices. The proposed model is compared to a system with time‐varying pricing for energy, where it is shown to allow consumers to use more appliances, to lead to a larger profit, and to reduce the peak‐to‐average ratio of energy consumption. Finally, the impact of the use of energy storage in households and in the energy provider is also considered.
Assessing the fertility of two mares cloned from the same founder animal
Authors: Dordas‐Perpinyà Marta , Pintart Cécile , Terris Hubert , Normandin Laure , Bruyas Jean‐François 
Published: November 2019

AbstractTwo cloned mares, produced from the same sample of skin fibroblasts, were bred during four breeding seasons from their second year of age, as embryo donors, in exactly the same conditions, using the same stallions for both cloned mares. The aim of this study was to test the embryo donor potential of cloned mares and to compare the results obtained from two cloned mares of the same mare with other embryo donor mares (n = 31–39 per breeding season) at the same stud. For both cloned mares, 19 embryos were recovered by 43 collection attempts (44%) (7/22 for one; 12/21 for the other), 16 (84%) pregnancies (5/7 for one, 11/12 for the other) were obtained at day 14 post‐ovulation (D14), and 12 (3/7 for one; 9/12 for the other) foals were born. One cloned mare was a less efficient donor mare than the other (p < .05), In control donor mares, 623 embryo collections were performed, with a recovery rate (80%—496/623) significantly higher than for cloned mares. The recovery rate in the subpopulation of 2–5‐year‐old control donor mares (same age of cloned mares) (89%—127/143) and The recovery rate in the subpopulation of 12 control mares bred with the seven same stallions as clones (55%—17/31), were both higher than for cloned mare (p < .05). The success rate of transfer was not different between embryos produced by cloned mares (84%—16/19) and those produced by control donor mares (79%—392/496). However, the foaling rate per embryo collection was significantly lower for cloned mares (28%—12/43) than for control donor mares (52% ‐ 325/623) (p < .05).
A laser ablation technique maps differences in elemental composition in roots of two barley cultivars subjected to salinity stress
Authors: Shelden Megan C. , Gilbert Sarah E. , Tyerman Stephen D. 
Published: November 2019

SummaryIn saline soils, high levels of sodium (Na+) and chloride (Cl−) ions reduce root growth by inhibiting cell division and elongation, thereby impacting on crop yield. Soil salinity can lead to Na+toxicity of plant cells, influencing the uptake and retention of other important ions [i.e. potassium (K+)] required for growth. However, measuring and quantifying soluble ions in their native, cellular environment is inherently difficult. Technologies that allowin situprofiling of plant tissues are fundamental for our understanding of abiotic stress responses and the development of tolerant crops. Here, we employ laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) to quantify Na, K and other elements [calcium (Ca), magnesium (Mg), sulphur (S), phosphorus (P), iron (Fe)] at high spatial resolution in the root growth zone of two genotypes of barley (Hordeum vulgare) that differ in salt‐tolerance, cv. Clipper (tolerant) and Sahara (sensitive). The data show that Na+was excluded from the meristem and cell division zone, indicating that Na+toxicity is not directly reducing cell division in the salt‐sensitive genotype, Sahara. Interestingly, in both genotypes, K+was strongly correlated with Na+concentration, in response to salt stress. In addition, we also show important genetic differences and salt‐specific changes in elemental composition in the root growth zone. These results show that LA‐ICP‐MS can be used for fine mapping of soluble ions (i.e. Na+and K+) in plant tissues, providing insight into the link between Na+toxicity and root growth responses to salt stress.
Lysosomal size matters
Authors: de Araujo Mariana E. G. , Liebscher Gudrun , Hess Michael W. , Huber Lukas A. 
Published: November 2019

AbstractLysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra‐ and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.
Working Fluid Dependence on Source Temperature for Organic Rankine Cycles
Authors: Pasinato Hugo Darío 
Published: November 2019

Abstract
This paper presents the results of numerical simulations of organic Rankine cycles (ORCs) for low-grade heat source temperature in the range of 373–653 K for 20 working fluids. The goal of the study is to determine the importance of the level of the source temperature in the selection of working fluids and operation conditions. As a performance indicator, a function of the net power, the internal and external exergy efficiencies, and the exergy efficiency of the evaporator is used. The results show that there is a strong correlation between the level of the source temperature and the critical temperature, between the expander inlet temperature and the source temperature, and between the expander inlet pressure and the critical pressure of the working fluids tested. The study shows that once the source temperature level is known, it is possible to select the working fluid and the conditions at the expander entrance.
The Mesoproterozoic Baoban Complex, South China: A missing fragment of western Laurentian lithosphere
Authors: Xu Ya-Jun , Cawood Peter A. , Zhang Hang-Chuan , Zi Jian-Wei , Zhou Jin-Bo , Li Li-Xing , Du Yuan-Sheng 
Published: November 2019

Abstract
New age data for the Baoban Complex, South China establishes that it lay outboard of western Laurentia in the early Mesoproterozoic but was not part of the Cathaysia Block, with which it is traditional linked, until the mid-Paleozoic. Our geochronology data for detrital zircon and authigenic monazite grains from metasedimentary rocks indicate accumulation between ca. 1.55 Ga and 1.45 Ga for the Gezhencun succession of the Baoban Complex and ca. 1.45 Ga and 1.30 Ga for the Ewenling succession. The former unit is dominated by detrital zircon populations between 1900 Ma and 1500 Ma with two peaks at 1780 Ma and 1580 Ma. The Ewenling succession has detrital zircon peaks at 1720 Ma and 1450 Ma. Newly discovered gneissic granites were emplaced at 1550 Ma and intruded by 1450 Ma leucogranite dykes that are coeval with 1460–1430 Ma bimodal magmatism. The whole Baoban Complex was metamorphosed over the range of 1.3–0.9 Ga based on ages of authigenic zircon and monazite.
Depositional ages of metasedimentary rocks are coeval with successions of the Belt-Purcell Basin, western Laurentia. Detrital zircon from the two regions have similar age populations and Lu-Hf compositions, and display a synchronous provenance shift at ca. 1.45 Ga. Basement lithologies on Hainan Island range in age from ca. 1.55–1.43 Ga and underwent metamorphism during 1.3–0.9 Ga. This is younger than basement rocks on the mainland of the Cathaysia Block in South China, suggesting the two regions are spatially unrelated at this time and hence the Mesoproterozoic record of the island cannot constrain the location of the Cathaysia Block in the Nuna and Rodinia supercontinents.
Internet based vestibular rehabilitation with and without physiotherapy support for adults aged 50 and older with a chronic vestibular syndrome in general practice: three armed randomised controlled trial
Authors: van Vugt Vincent A , van der Wouden Johannes C , Essery Rosie , Yardley Lucy , Twisk Jos W R , van der Horst Henriëtte E , Maarsingh Otto R 
Published: November 2019

AbstractObjectiveTo investigate the clinical effectiveness and safety of stand alone and blended internet based vestibular rehabilitation (VR) in the management of chronic vestibular syndromes in general practice.DesignPragmatic, three armed, parallel group, individually randomised controlled trial.Setting59 general practices in the Netherlands.Participants322 adults aged 50 and older with a chronic vestibular syndrome.InterventionsStand alone VR comprising a six week, internet based intervention with weekly online sessions and daily exercises (10-20 minutes a day). In the blended VR group, the same internet based intervention was supplemented by face-to-face physiotherapy support (home visits in weeks 1 and 3). Participants in the usual care group received standard care from a general practitioner, without any restrictions.Main outcome measuresThe primary outcome was vestibular symptoms after six months as measured by the vertigo symptom scale-short form (VSS-SF range 0-60, clinically relevant difference ≥3 points). Secondary outcomes were dizziness related impairment, anxiety, depressive symptoms, subjective improvement of vestibular symptoms after three and six months, and adverse events.ResultsIn the intention-to-treat analysis, participants in the stand alone and blended VR groups had lower VSS-SF scores at six months than participants in the usual care group (adjusted mean difference −4.1 points, 95% confidence interval −5.8 to −2.5; and −3.5 points, −5.1 to −1.9, respectively). Similar differences in VSS-SF scores were seen at three months follow-up. Participants in the stand alone and blended VR groups also experienced less dizziness related impairment, less anxiety, and more subjective improvement of vestibular symptoms at three and six months. No serious adverse events related to online VR occurred during the trial.ConclusionStand alone and blended internet based VR are clinically effective and safe interventions to treat adults aged 50 and older with a chronic vestibular syndrome. Online VR is an easily accessible form of treatment, with the potential to improve care for an undertreated group of patients in general practice.Trial registrationNetherlands Trial Register NTR5712.
Equality of opportunity is linked to lower mortality in Europe
Authors: Gugushvili Alexi , Kaiser Caspar 
Published: November 2019

BackgroundThis study investigates if intergenerational equality of opportunity is linked to mortality in 30 European countries. Equality of opportunity may lead to greater returns on health investments and, consequently, improved health outcomes. In turn, a perceived lack of fairness in the distribution of life chances and limited possibilities for upward intergenerational mobility can cause anxiety among individuals and gradually compromise their health.MethodsWe used information on 163 467 individuals’ and their parents’ Socio-Economic Index of Occupational Status from a large survey data set—the European Social Survey—to generate three complementary measures of equality of opportunity. We then linked these to administrative data on total, gender-specific and cause-specific mortality rates assembled by Eurostat from the national statistical offices.ResultsWe found that lower equality of opportunity, measured by the attainment of individuals from the lowest and highest quartiles of socioeconomic status and by the overall intergenerational correlation in socioeconomic status, was related to higher mortality rates, particularly in relation to diseases of the nervous system and the sense organs, diseases of the respiratory system and external causes of mortality. Our measures of equality of opportunity were more consistently linked with mortality of men than women.ConclusionEquality of opportunity may be an important explanation of mortality that warrants further research. Measures that aim at facilitating intergenerational social mobility can be justified not only via normative considerations of equality of opportunity but also in terms of individuals’ chances to enjoy healthy lives.
Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice
Authors: McCann Emily P , Fifita Jennifer A , Grima Natalie , Galper Jasmin , Mehta Prachi , Freckleton Sarah E , Zhang Katharine Y , Henden Lyndal , Hogan Alison L , Chan Moi Fat Sandrine , Wu Sharlynn SL , Jagaraj Cyril J , Berning Britt A , Williams Kelly Louise , Twine Natalie A , Bauer Denis , Piguet Olivier , Hodges John , Kwok John B J , Halliday Glenda M , Kiernan Matthew C , Atkin Julie , Rowe Dominic B , Nicholson Garth A , Walker Adam K , Blair Ian P , Yang Shu 
Published: November 2019

ObjectiveSince the first report ofCHCHD10gene mutations in amyotrophiclateral sclerosis (ALS)/frontotemporaldementia (FTD) patients, genetic variation inCHCHD10has been inconsistently linked to disease. A pathological assessment of the CHCHD10 protein in patient neuronal tissue also remains to be reported. We sought to characterise the genetic and pathological contribution of CHCHD10 to ALS/FTD in Australia.MethodsWhole-exome and whole-genome sequencing data from 81 familial and 635 sporadic ALS, and 108 sporadic FTD cases, were assessed for genetic variation inCHCHD10. CHCHD10 protein expression was characterised by immunohistochemistry, immunofluorescence and western blotting in control, ALS and/or FTD postmortem tissues and further in a transgenic mouse model of TAR DNA-binding protein 43 (TDP-43) pathology.ResultsNo causal, novel or disease-associated variants inCHCHD10were identified in Australian ALS and/or FTD patients. In human brain and spinal cord tissues, CHCHD10 was specifically expressed in neurons. A significant decrease in CHCHD10 protein level was observed in ALS patient spinal cord and FTD patient frontal cortex. In a TDP-43 mouse model with a regulatable nuclear localisation signal (rNLS TDP-43 mouse), CHCHD10 protein levels were unaltered at disease onset and early in disease, but were significantly decreased in cortex in mid-stage disease.ConclusionsGenetic variation inCHCHD10is not a common cause of ALS/FTD in Australia. However, we showed that in humans, CHCHD10 may play a neuron-specific role and a loss of CHCHD10 function may be linked to ALS and/or FTD. Our data from the rNLS TDP-43 transgenic mice suggest that a decrease in CHCHD10 levels is a late event in aberrant TDP-43-induced ALS/FTD pathogenesis.
Presumptive antibiotics in tube thoracostomy for traumatic hemopneumothorax: a prospective, Multicenter American Association for the Surgery of Trauma Study
Authors: Cook Alan , Hu Chengcheng , Ward Jeanette , Schultz Susan , Moore III Forrest O"Dell , Funk Geoffrey , Juern Jeremy , Turay David , Ahmad Salman , Pieri Paola , Allen Steven , Berne John 
Published: November 2019

BackgroundThoracic injuries are common in trauma. Approximately one-third will develop a pneumothorax, hemothorax, or hemopneumothorax (HPTX), usually with concomitant rib fractures. Tube thoracostomy (TT) is the standard of care for these conditions, though TTs expose the patient to the risk of infectious complications. The controversy regarding antibiotic prophylaxis at the time of TT placement remains unresolved. This multicenter study sought to reconcile divergent evidence regarding the effectiveness of antibiotics given as prophylaxis with TT placement.MethodsThe primary outcome measures of in-hospital empyema and pneumonia were evaluated in this prospective, observational, and American Association for the Surgery of Trauma multicenter study. Patients were grouped according to treatment status (ABX and NoABX). A 1:1 nearest neighbor method matched the ABX patients with NoABX controls. Multilevel models with random effects for matched pairs and trauma centers were fit for binary and count outcomes using logistic and negative binomial regression models, respectively.ResultsTTs for HPTX were placed in 1887 patients among 23 trauma centers. The ABX and NoABX groups accounted for 14% and 86% of the patients, respectively. Cefazolin was the most frequent of 14 antibiotics prescribed. No difference in the incidence of pneumonia and empyema was observed between groups (2.2% vs 1.5%, p=0.75). Antibiotic treatment demonstrated a positive but non-significant association with risk of pneumonia (OR 1.61; 95% CI: 0.86~3.03; p=0.14) or empyema (OR 1.51; 95% CI: 0.42~5.42; p=0.53).ConclusionThere is no evidence to support the routine use of presumptive antibiotics for post-traumatic TT to decrease the incidence of pneumonia or empyema. More investigation is necessary to balance optimal patient outcomes and antibiotic stewardship.Level of evidenceII Prospective comparative study
Constraints on barotropic dark energy models by a new phenomenological q(z) parameterization
Authors: Román-Garza Jaime , Verdugo Tomás , Magaña Juan , Motta Verónica 
Published: November 2019

Abstract
In this paper, we propose a new phenomenological two parameter parameterization of q(z) to constrain barotropic dark energy models by considering a spatially flat Universe, neglecting the radiation component, and reconstructing the effective equation of state (EoS). This two free-parameter EoS reconstruction shows a non-monotonic behavior, pointing to a more general fitting for the scalar field models, like thawing and freezing models. We constrain the q(z) free parameters using the observational data of the Hubble parameter obtained from cosmic chronometers, the joint-light-analysis Type Ia Supernovae (SNIa) sample, the Pantheon (SNIa) sample, and a joint analysis from these data. We obtain, for the joint analysis with the Pantheon (SNIa) sample a value of q(z) today, $$q_0=-0.51\begin{array}{c} +0.09 \\ -0.10 \end{array}$$q0=-0.51+0.09-0.10, and a transition redshift, $$z_t=0.65\begin{array}{c} +0.19 \\ -0.17 \end{array}$$zt=0.65+0.19-0.17 (when the Universe change from an decelerated phase to an accelerated one). The effective EoS reconstruction and the $$\omega '$$ω′–$$\omega $$ω plane analysis point towards a transition over the phantom divide, i.e. $$\omega =-1$$ω=-1, which is consistent with a non parametric EoS reconstruction reported by other authors.