bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical diagnostic criteria of efficiency for combined etiopathogenetic therapy in patients with chronic Epstein–Barr virus infection
Authors: Zurochka V. A. , Zabkov O. I. , Dobrynina M. A. , Gritsenko V. F. , Davydova E. V. , Chukichev A. V. , Zabokritskii N. A. , Sarapultsev A. P. , Zurochka A. V. 
Published: April 2020

Treatment of chronic viral infections accompanied by permanent virus persistence in the target epitopes of the oral cavity, skin, urogenital tract is complicated by virtual lack of available drugs exerting combined systemic virulicidal and immunomodulatory effects. Here we demonstrate clinical and immunological efficacy of combined therapy in treatment of Epstein–Barr virus (EBV)-associated chronic infections. The aim of the study was to evaluate the clinical and immunological efficacy of combined etiopathogenetic therapy using the Acegram cosmetic product in patients with EBV-associated chronic infections. Materials and methods. There were enrolled 40 patients monitored before treatment as well as 20 patients followed up after combination therapy (cycle therapy consisted of oral valaciclovir (Valtrex) applied at dose of 500 μg twice a day for 10 days, glucosaminylmuramyldipeptide (Licopid) — 10 mg 2 twice a day for 10 days, topical irrigation for mucous membranes with granulocyte-macrophage colony-stimulating factor active center-derived peptide (Acegram-spray) 3 times a day for 10 days. If necessary, treatment courses were repeated 20 days after the onset. All patients were examined for the presence of EBV genomes in the oral fluid and blood using the qualitative and quantitative polymerase chain reaction (PCR) using the DNA technology test system (Russia) on a DT-Lite device prior treatment and 30, 60 days post-therapy time points. In addition, serum samples were analyzed for level of class G immunoglobulins specific to the EBV nuclear and capsid antigens by using enzyme immunoassay (test systems manufactured by CJSC Vector Best, Russia) as well as immune status (clinical methods, enu flow cytometry evaluation of the phagocytic activity of neutrophils, ELISA method). Results. Use of single or two course combination therapy in subjects with fully eradicated EBV carriage associated with reversed clinical symptoms was accompanied by recovered immune system status (T and B cells, T-helper cells, CD3+ CD25+ cells, phagocytosis parameters). A non-invasive approach proposed for controlling virus elimination in the oral fluid by using polymerase chain reaction method may serve as to objectively monitor therapeutic efficacy.
Metabolic changes in peripheral blood lymphocytes from children with recurrent respiratory infections
Authors: Kurtasova L. M. , Shakina N. A. , Lubnina T. V. 
Published: April 2020

Objective: to examine activity and correlative relations for peripheral blood lymphocyte NAD (P)-dependent dehydrogenases in young children with recurrent respiratory infections with hypertrophy of the pharyngeal tonsils and bronchial obstructive syndrome. Methods. 89 children, aged 1–3 years, with recurrent respiratory infections were examined, including 35 children with hypertrophy of pharyngeal tonsils (HPT) and 54 children — with bronchial obstructive syndrome (BOS). Control group contained 20 age-matched healthy children. Activity and relations for peripheral blood lymphocyte for NAD(P)-dependent dehydrogenases were assessed by using bioluminescent method proposed by А.А. Savchenko and L.N. Suntsova (1989). Results. It was found that children with recurrent respiratory infections displayed altered enzyme status in peripheral blood lymphocytes. In particular, activity ribose-5-phosphate- and NAD(P)-dependent metabolic events as well as substrate flux via the tricarboxylic acid cycle were elevated that was paralleled with decreased lactate dehydrogenase anaerobic reaction, thereby implicating a role for malate-aspartate shunt in the energy turnover, substrate efflux from the tricarboxylic acid cycle into amino acid metabolic pathways as well as activity of glutathione reductase. Moreover, features of altered enzymatic profile in peripheral blood lymphocytes were uncovered, which depended on type of complication related to respiratory infection. In addition, children with hypertrophy of pharyngeal tonsils were featured with increased influx of lipid catabolism products into glycolysis, elevated level of malic enzyme activity and decreased pyruvate production. However, children with bronchial obstructive syndrome were found to have decreased glycerol-3-phosphate dehydrogenase activity resulting in lowered shunting activity of slow reactions in Krebs cycle and increased influx of amino acid metabolism intermediates into the tricarboxylic acid cycle. Reshaping of enzymatic profile in peripheral blood lymphocytes depended on type of complications coupled to respiratory infections (ENT-pathology or BOS syndrome). A correlation analysis revealed features of relationship between parameters of NAD(P)-dependent dehydrogenase activity in peripheral blood lymphocytes found in children with hypertrophy of pharyngeal tonsils and bronchial obstructive syndrome marked by quantity, modality and power of correlative links. Conclusion. Children with the recurrent respiratory infections require metabolic therapy aimed at restoring intracellular pathology-driven metabolic processes in immune cells.
UPAYA MENINGKATKAN KETERAMPILAN KOMUNIKASI SISWA DALAM PEMBELAJARAN SEJARAH MELALUI STRATEGI GIVING QUESTION GETTING ANSWER
Authors: Indriyani Ulfi , Supriatna Nana , Sumantri Yeni Kurniawati 
Published: April 2020

Penelitian ini bertujuan untuk meningkatkan keterampilan komunikasi siswa dalam pembelajaran sejarah dengan menerapkan strategi pembelajaran Giving Question Getting Answer. Berdasarkan hasil observasi pra-penelitian yang dilakukan di kelas XI MIPA 2 SMA Negeri 15 Bandung menunjukkan rendahnya keterampilan komunikasi siswa dalam pembelajaran sejarah. Permasalahan tersebut muncul karena pada proses pembelajaran, komunikasi terjadi hanya satu arah yaitu guru hanya menyampaikan materi tanpa respon yang cukup dari siswa dengan mengajukan pertanyaan atau berpendapat sehingga siswa cenderung pasif. Oleh karena itu peneliti mencoba melakukan penelitian dengan menggunakan metode Penelitian Tindakan Kelas dengan desain Kemmis-Taggart yang meliputi empat kegiatan yang akan dilakukan dalam setiap siklus, yaitu perencanaan, tindakan, observasi dan refleksi. Teknik pengumpulan data yang digunakan adalah observasi, catatan lapangan, wawancara dan studi dokumentasi. Indikator-indikator dalam penelitian ini terdiri dari mengajukan pertanyaan, menyampaikan informasi, menarik kesimpulan, kejelasan penyampaian, penguasaan materi, interaksi dalam kelompok dan pemberian respon yang dikembangkan menjadi tiga sub indikator. Seluruh aspek tersebut mengalami peningkatan yang baik pada setiap siklusnya. Presentase rata-rata perolehan skor keseluruhan indikator pada Siklus I sebanyak 47,2%, kemudian mengalami peningkatan pada Siklus II menjadi 68,3%, pada Siklus III kembali terjadi peningkatan menjadi 82%, dan pada Siklus IV mencapai 92,8%. Dengan demikian, dapat disimpulkan bahwa keterampilan komunikasi siswa dalam pembelajaran sejarah dapat ditingkatkan setelah penerapan strategi pembelajaran Giving Question Getting Answer dalam empat siklus.
Nursing Practice guidelines for needling of A.V Fistula/grafts: Beni-Suef City, Egypt.
Authors: Bayoumi Magda , Khonji Leena 
Published: April 2020

Introduction: Vascular access is considering to the patient undergoing hemodialysis (HD) as his/her soul which indicating patient survival, moreover, vascular access can controlling, directing the dialysis regimen effectiveness. Cannulation techniques are a crucial skill for nurses to minimize arteriovenous fistula (AVF) or graft (AVG) complications.
Methods: A cross-sectional study was applied to assess vascular complication and related factors. The participants were 65 patients on maintenance HD therapy enrolled at the dialysis unit, central Ehnasa’ government hospital, Beni Suef City. Data were collected using developed questionnaires regard patients’ demographic data, clinical, and HD session characteristics, designed Nursing Practice guidelines for needling of AVF/AVG booklet.
Results: Statistically, the results show the most common cannulation technique which was demonstrated is an area method (65%) and needle direction is retrograde with bevel up (66.2%). whereas, the significant positive correlation shows between the cannulation techniques and vascular access complication, duration of dialysis and complication during the dialysis session. Furthermore, the most common complication related to needling practice is aneurysm (44.6%).
Conclusion: Following cannulation, technique guidelines will prevent potential complication, increase vascular access durability, and improve patients’ quality of life.
Complex Temporal Patterns of Large Earthquakes: Devil’s Staircases
Authors: Chen Yuxuan , Liu Mian , Luo Gang 
Published: April 2020

ABSTRACTPeriodic or quasiperiodic earthquake recurrence on individual faults, as predicted by the elastic rebound model, is not common in nature. Instead, most earthquake sequences are complex and variable, and often show clusters of events separated by long but irregular intervals of quiescence. Such temporal patterns are especially common for large earthquakes in complex fault zones or regional and global fault networks. Mathematically described as the Devil’s Staircase, such temporal patterns are a fractal property of nonlinear complex systems, in which a change of any part (e.g., rupture of a fault or fault segment) could affect the behavior of the whole system. We found that the lengths of the quiescent intervals between clusters are inversely related to tectonic-loading rates, whereas earthquake clustering can be attributed to many factors, including earthquake-induced viscoelastic relaxation and fault interaction. Whereas the underlying causes of the characteristics of earthquake sequences are not fully known, we attempted to statistically characterize these sequences. We found that most earthquake sequences are burstier than the Poisson model commonly used in probabilistic seismic hazard analysis, implying a higher probability of repeating events soon after a large earthquake.
Colonización y los cuerpos-territorio: protagonismo de las mujeres indígenas en el conflicto por el TIPNIS, Bolivia
Authors: Makaran Gaya 
Published: April 2020

<p>El presente artículo tiene como objetivo mostrar el papel de las mujeres indígenas en la defensa del Territorio Indígena y Parque Nacional Isiboro Secure (TIPNIS) en la Amazonía boliviana, frente al proyecto carretero y la colonización cocalera promovidas por el gobierno de Evo Morales Ayma. El estudio de la resistencia en el TIPNIS nos servirá para ilustrar la relación actual entre el colonialismo, el capitalismo y el patriarcado, por una parte, y la (auto)identificación de los cuerpos femeninos con el territorio en disputa. Estamos partiendo de un contexto global y nacional más amplio, donde el Estado boliviano bajo los gobiernos “progresistas” del Movimiento al Socialismo (MAS) se caracteriza por un nacionalismo unificador y “modernizante” basado en el extractivismo acelerado y una proyección desarrollista que contradice los principios plurinacionales y proindígenas declarados, y asevera el despojo de los territorios y recursos por el capital, sobre todo transnacional.</p>
El desarrollo de la actividad turística en el municipio de Paderne
Authors: Rico Rico Beatriz 
Published: April 2020

En el presente articulo se hace un análisis del sector turístico en el municpio de Paderne, una vez realizado el marco teórico centrado en la planificación, el desarrollo local y la sostenibilidad en zonas rurales, se estudia los principales atractivos del lugar así como la oferta turística existente; tras la realización de una serie de entrevistas a empresarios y administración local así como el posterior establecimiento de unas lineas estratégicas de desarrollo, las conclusiones finales nos permiten tener una imagen global de la actividad turística en el municipio cuyo potencial de desarrollo vendrá determinado por la cohesión entre comunidad local, sector privado y sector público.
Nuevas tecnologías y difusión del turismo cultural: descubriendo a Goya con realidad aumentada
Authors: Bernad Conde María 
Published: April 2020

La introducción de la realidad aumentada permite agregar información de interés para un destino turístico. Además, contribuye a aumentar la atracción e incrementar el mercado de visitantes. En la actualidad la adopción de tecnologías de realidad virtual aplicadas al patrimonio cultural está en un estadio de desarrollo. En este artículo se analizan esas tecnologías y, en particular, la app de Fuendetodos. Los resultados concluyen que el uso de la app permite aumentar la información y la experiencia vivida del visitante sobre Goya y la localidad de Fuendetodos.
Targeted therapy for gastrointestinal and pancreatic neuroendocrine tumors
Authors: Isyangulova A.  Z. , Khasanov R.  Sh. , Enikeev R.  F. 
Published: April 2020

Extensive investigation of neuroendocrine tumors (NETs) has only started in recent years. The increased attention to this issue is due to the more frequent detection of NETs as a result of diagnostic methods improvement.The limited effectiveness of chemotherapy for well-differentiated advanced metastatic NETs of gastrointestinal tract (GIT) and pancreas demonstrates the need for development of the new and more effective treatment options.Recent studies on specific biological features of NETs have led to the development of the new targeted therapies which take into account high vascularization and overexpression of specific growth factors and related tyrosine kinase receptors. Thus, studying the mTOR TSC2, PTEN and PIK3CA signaling pathways opens up the new opportunities in the treatment of gastrointestinal or pancreatic NETs, especially in case of inoperable or metastatic tumors. Targeted therapy, which specifically inhibits growth factor receptors and related signaling pathways, is a promising approach to drug therapy for patients with gastrointestinal or pancreatic NETs.This review summarizes the state of the art and prospects for using targeted therapy, and describes clinical studies in the treatment of gastrointestinal and pancreatic NETs.
TAX AVOIDANCE IN INDONESIA: CONTEXT OF GOOD CORPORATE GOVERNANCE AND CORPORATE SOCIAL RESPONSIBILITY
Authors: Kiswanto  , Harjanto Atta Putra , Suryarini Trisni , Apriliyana Nining , Kadir Abdul 
Published: April 2020

Purpose of the study: The objective of the study is to analyze the impact of Corporate Governance and Corporate Social Responsibility Quality on Tax Avoidance.
Methodology: The population of this research is the audit report of the Audit Board of the Republic of Indonesia (BPK) in the Regency/City of West Indonesia with a total of 263 financial statements. Purposive sampling method is used, resulting 186 financial statements as samples. Hypotheses are tested using multiple linear regression using SPSS V.21.
Main Findings: This study population is a manufacturing company in Indonesia. Data are then analyzed by descriptive statistics and multiple linear regression. It is a quantitative study with 150 companies as the population of the study. They are all manufacturing companies listed on Indonesia Stock Exchange (IDX) from 2013 up to 2015.
Applications of this study: This study can be useful for good corporate governance dan corporasi social responsibility
Novelty/Originality of this study: Tax avoidance, good corporate governance and good social responsibility are included in this study. There are only a few studies that use these variables. This study uses a different proxy from the previous one with the aim of getting more accurate results.
INVESTIGATING EXPERIENCED AND NOVICE ENGLISH LANGUAGE LEARNERS` PERCEPTIONS of MOST USEFUL VOCABULARY LEARNING STRATEGIES (VLS)
Authors: Zariholhosseini Elnaz , Namaziandost Ehsan , Nasri Mehdi 
Published: April 2020

Purpose of the study: This article report’s findings from a study on the differences and similarities between experienced and novice English language learners with regards to their personal use of VLS.
Methodology: Closed questionnaire and semi-structure interviews were applied to collect the data. The questionnaire was distributed among 60 (30 experienced learners and 30 novice learners). In addition, 20 learners (10 experienced learners and 10 novice learners) were asked to answer the questions in the interview. Therefore, descriptive statistics, U Mann Whitney test, and independent-sample t-test were run to compare and analyzed the data.
Main Findings: The finding showed that there were significant differences between experienced and novice learners’ thoughts towards vocabulary learning strategies and experienced learners used vocabulary learning strategies while learning new words in English language learning.
Applications of this study: If the learners are taught how to use each strategy correctly, their understanding of the language can naturally be improved. Moreover, VLS is beneficial throughout the process of vocabulary learning which makes learners more independent and allows teachers to focus on other things as well.
Novelty/Originality of this study: To the best of researchers’ knowledge, no study has been done on investigating Iranian experienced and novice English language learners` perceptions towards most useful vocabulary learning strategies (VLS).
BACHELORS’ INDEPENDENT WORK: STAGES OF ORGANIZATION THROUGH THE APPLICATION OF SIMULATION TECHNOLOGY
Authors: Raptanova I. N. , Streneva N. V. , Strizhkova O. V. , Fomichenko A. S. , Yankina N. V. 
Published: April 2020

Purpose of the study: The article analyses the problem of the students’ independent work organization within the framework of simulation technology. We placed the main emphasis on the stages of the organization of University students’ self-study of a foreign language. Moreover, we assess how the application of simulation technology raises the efficiency of students’ independent work.
Methodology: We wrote the article on data collected from surveys in 2018. Students from the Orenburg State University participated in this research. This study used the quantitative approach of experimental research by dividing students into two groups, experimental and control ones. We collected the data through questionnaires, interviews, and documentation. We used statistical methods of survey data processing for analysis, among them descriptive analysis, correlation, and factor analyses.
Main Findings: Simulation technology is an active and innovative tool in education. The organization of students’ independent work within the frame of the simulation technology promotes the development of initiative and self-sufficient students. It contributes to the improvement of the subjective bachelors’ qualities such as strength of linguistic knowledge, linguistic and reflexive skills. Besides, students understood the importance of independent work in the educational process.
Applications of this study: The material of the study can be useful for university teachers and students and a wide range of readers interested in a new developing and innovative way of learning in the education of students.
Novelty/Originality of this study: In this article, we described the organization of students’ independent work within the frame of the simulation technology. The results can be used by university teachers as an innovative tool for students learning. This method of intensification of learning activity can lead to the creation of an own model of teaching the students.
APPLYING ITEM RESPONSES THEORY FOR MEASURING STUDENT’S ABILITY IN ACADEMIC SPEAKING
Authors: Sudaryanto Memet , Saddhono Kundharu , Lina  
Published: April 2020

Purpose of the study: Every human being is required to be skilled at communicating, skilled at expressing thoughts, ideas, and feelings. This research aims to explain student’s ability in academic speaking based on the framework of item responses theory. Methodology: This research uses a mix method research approach; qualitative and quantitative approaches are used together to answer the formulated problems. A qualitative approach is used for digging up information about the needs to develop the speaking test. The try out subjects was 25 university student taking Bahasa Indonesia subject; while 125 students were used as the measurement subject. The data were students’ responses to the speaking test which was scored by two people (rater). The reliability of the instrument was estimated by the Generalizability theory. Rasch model analysis was used to estimate the item parameter; while the Maximum Likelihood was used to estimate the students’ ability. Main Findings: The value of 𝜎 ̂(𝑜) s influenced by the similarity to the average mean score observed in academic speaking. The value of 𝜎 ̂(𝑝) and 𝜎 ̂(𝑜) suggests that the distribution of variability in person and item is the same and high. A sufficiently large value of 𝜎 ̂(𝑝i) implies the fact that the value involves all residual sources for a variance. Balance alternatives, weigh consequently and decide rationally. Applications of this study: Based on the design proposed for the Indonesian Language Proficiency assessment, other generalizability design (G-Design) used is a cross design because each student (p) becomes the object of observation of two observers (r) who both assess four aspects of observation/indicator. It is used to determine the reliability (i.e., reproducibility) of measurements under specific conditions in academic speaking. Novelty/Originality of this study: Some rater qualifications that must be met include the process of gathering and using the appropriateness of background information before assessing. Measuring the ability of students in academic speaking by applying G theory and conducting an IRT analysis approach needs.
THE IMPLEMENTATION OF SPIRITUAL QUOTIENT-BASED BEHAVIORAL GROUP COUNSELING IN STRENGTHENING CREATIVE AND INNOVATIVE TRAITS TO OPTIMIZE STUDENTS’ HARD SKILLS
Authors: Heru Sri Suryanti Hera 
Published: April 2020

Purpose of the study: The research aims at finding how spiritual quotient-based behavioral group counseling is implemented to strengthen the creative and innovative aspects aimed at improving students’ hard skills.
Methodology: The research is a qualitative method. The subject of the study is the students of the Guidance and Counseling Program at Private University in Solo Raya. The focus of the study is the implementation of spiritual quotient-based behavioral group counseling. The data are collected through interviews, observation, documentation, and test. They are validated through triangulation. They are analyzed through qualitative analysis.
Main Findings: Research findings shows that the implementation of spiritual quotient-based behavioral group counseling can strengthen the creative and innovative aspects aimed at improving students’ hard skill at Guidance and Counseling Programmed at Private University in Solo Raya. It can be seen from the students’ behavior change, i.e. from uncreative and less innovative to be creative and innovative.
Applications of this study: Findings of the research are useful as a reference enrichment conducting learning in guidance counseling courses especially for counseling theory. This study is also useful as a guideline for implementing group counseling practices for students and lecturers of counseling guidance at the national level because of the results of the study in terms of the implementation of the counseling technique.
Novelty/Originality of this study: This research contains novelty in counseling i.e. the implementation of spiritual intelligence-based counseling to improve student hard skills, which still rarely has never been done by other researchers. This research is beneficial to advance the field of guidance and counseling, namely to increase the implementation of group counseling in building soft skills and the hard skill of students.