bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial
Authors: Järvelä-Reijonen Elina , Puttonen Sampsa , Karhunen Leila , Sairanen Essi , Laitinen Jaana , Kolehmainen Mikko , Pihlajamäki Jussi , Kujala Urho M , Korpela Riitta , Ermes Miikka , Lappalainen Raimo , Kolehmainen Marjukka 
Published: May 2020

AbstractBackgroundPsychological processes can be manifested in physiological health. We investigated whether acceptance and commitment therapy (ACT), targeted on psychological flexibility (PF), influences inflammation and stress biomarkers among working-age adults with psychological distress and overweight/obesity.MethodParticipants were randomized into three parallel groups: (1) ACT-based face-to-face (n = 65; six group sessions led by a psychologist), (2) ACT-based mobile (n = 73; one group session and mobile app), and (3) control (n = 66; only the measurements). Systemic inflammation and stress markers were analyzed at baseline, at 10 weeks after the baseline (post-intervention), and at 36 weeks after the baseline (follow-up). General PF and weight-related PF were measured with questionnaires (Acceptance and Action Questionnaire, Acceptance and Action Questionnaire for Weight-Related Difficulties).ResultsA group × time interaction (p = .012) was detected in the high-sensitivity C-reactive protein (hsCRP) level but not in other inflammation and stress biomarkers. hsCRP decreased significantly in the face-to-face group from week 0 to week 36, and at week 36, hsCRP was lower among the participants in the face-to-face group than in the mobile group (p = .035, post hoc test). Age and sex were stronger predictors of biomarker levels at follow-up than the post-intervention PF.ConclusionThe results suggest that ACT delivered in group sessions may exert beneficial effects on low-grade systemic inflammation. More research is needed on how to best apply psychological interventions for the health of both mind and body among people with overweight/obesity and psychological distress.Trial RegistrationClinicalTrials.govIdentifier: NCT01738256, Registered 17 August, 2012
An ETA Prediction Model for Intermodal Transport Networks Based on Machine Learning
Authors: Balster Andreas , Hansen Ole , Friedrich Hanno , Ludwig André 
Published: May 2020

AbstractTransparency in transport processes is becoming increasingly important for transport companies to improve internal processes and to be able to compete for customers. One important element to increase transparency is reliable, up-to-date and accurate arrival time prediction, commonly referred to as estimated time of arrival (ETA). ETAs are not easy to determine, especially for intermodal freight transports, in which freight is transported in an intermodal container, using multiple modes of transportation. This computational study describes the structure of an ETA prediction model for intermodal freight transport networks (IFTN), in which schedule-based and non-schedule-based transports are combined, based on machine learning (ML). For each leg of the intermodal freight transport, an individual ML prediction model is developed and trained using the corresponding historical transport data and external data. The research presented in this study shows that the ML approach produces reliable ETA predictions for intermodal freight transport. These predictions comprise processing times at logistics nodes such as inland terminals and transport times on road and rail. Consequently, the outcome of this research allows decision makers to proactively communicate disruption effects to actors along the intermodal transportation chain. These actors can then initiate measures to counteract potential critical delays at subsequent stages of transport. This approach leads to increased process efficiency for all actors in the realization of complex transport operations and thus has a positive effect on the resilience and profitability of IFTNs.
Feasibility study and numerical simulation to design the steam flooding pilot test patterns
Authors: Elbaloula Husham A. , Jin’e Chen , Zichang Tang , Yu Wang , Abdelmajeed Mohammed , Hamd Mosab F. 
Published: May 2020

AbstractSteam flooding is a method of injecting steam to heat the oil and decrease its viscosity so that it will be easy to flow from injector to producer. Fula North East oil field is a massive edge and bottom water reservoir with good properties and high viscosity of crude oil. As of March 2018, the oil field has been fully commissioned in steam stimulation for 3 years and the water cut rises rapidly and the oil rate declines seriously. In this paper, through comprehensive analysis of the geological properties of reservoir, production dynamics of single well and cement quality of wellbore, the steam flooding pilot test area under different well groups is screened out. Advanced thermal enhanced oil recovery simulator has been used to build the model of 279, 888 cells to design and optimize steam flooding pilot area for this field. The best well space and development program are optimized; this paper supplies a theoretical foundation for the next step of steam flooding in the whole field. The results show that the optimum steam flooding parameters for this area are steam injection temperature of 270 °C, with 5–7 MPa injection pressure, steam injection quality of more than 0.6 and steam injection rate of 1.6 m3/day/ha/m, and the final recovery ratio will reach 32.3%.
A practical guide to amplicon and metagenomic analysis of microbiome data
Authors: Liu Yong-Xin , Qin Yuan , Chen Tong , Lu Meiping , Qian Xubo , Guo Xiaoxuan , Bai Yang 
Published: May 2020

AbstractAdvances in high-throughput sequencing (HTS) have fostered rapid developments in the field of microbiome research, and massive microbiome datasets are now being generated. However, the diversity of software tools and the complexity of analysis pipelines make it difficult to access this field. Here, we systematically summarize the advantages and limitations of microbiome methods. Then, we recommend specific pipelines for amplicon and metagenomic analyses, and describe commonly-used software and databases, to help researchers select the appropriate tools. Furthermore, we introduce statistical and visualization methods suitable for microbiome analysis, including alpha- and beta-diversity, taxonomic composition, difference comparisons, correlation, networks, machine learning, evolution, source tracing, and common visualization styles to help researchers make informed choices. Finally, a step-by-step reproducible analysis guide is introduced. We hope this review will allow researchers to carry out data analysis more effectively and to quickly select the appropriate tools in order to efficiently mine the biological significance behind the data.
Genome-wide characterization of coding and non-coding RNAs in the ovary of honeybee workers and queens
Authors: Chen Xiao , Shi Wei 
Published: May 2020

AbstractAdult honeybee queens and workers drastically differ in ovary state and ovary size. However, this reproductive bias is only partially understood from the view of a single RNA type. In this study, we predicted 10,271 mRNAs, 7235 lncRNAs, 11,794 circRNAs, and 164 miRNAs in the ovary of honeybee workers through bioinformatics. Combining RNA sequencing data of honeybee virgin queens, 4385 mRNAs, 2390 lncRNAs, 5602 circRNAs, and 75 miRNAs were differentially expressed in workers compared with virgins. Compared with egg-laying queens, 6536 mRNAs, 3130 lncRNAs, 5751 circRNAs, and 81 miRNAs were differentially expressed in workers. Further, functional annotation revealed that neural regulation was closely related to ovary state. Moreover, the potential interactions among circRNAs, miRNAs, lncRNAs, and mRNAs revealed that vitellogenin, ecdysone-induced protein 74, ame_circ_0001176, and ame_circ_0001243 might play critical roles in the competing endogenous RNA network. These findings suggest that the integrative RNA networks have potential effects in ovarian phenotype differences in honeybees.
Development of an Ultra-Sensitive and Flexible Piezoresistive Flow Sensor Using Vertical Graphene Nanosheets
Authors: Abolpour Moshizi Sajad , Azadi Shohreh , Belford Andrew , Razmjou Amir , Wu Shuying , Han Zhao Jun , Asadnia Mohsen 
Published: May 2020

AbstractThis paper suggests development of a flexible, lightweight, and ultra-sensitive piezoresistive flow sensor based on vertical graphene nanosheets (VGNs) with a mazelike structure. The sensor was thoroughly characterized for steady-state and oscillatory water flow monitoring applications. The results demonstrated a high sensitivity (103.91 mV (mm/s)−1) and a very low-velocity detection threshold (1.127 mm s−1) in steady-state flow monitoring. As one of many potential applications, we demonstrated that the proposed VGNs/PDMS flow sensor can closely mimic the vestibular hair cell sensors housed inside the semicircular canals (SCCs). As a proof of concept, magnetic resonance imaging of the human inner ear was conducted to measure the dimensions of the SCCs and to develop a 3D printed lateral semicircular canal (LSCC). The sensor was embedded into the artificial LSCC and tested for various physiological movements. The obtained results indicate that the flow sensor is able to distinguish minute changes in the rotational axis physical geometry, frequency, and amplitude. The success of this study paves the way for extending this technology not only to vestibular organ prosthesis but also to other applications such as blood/urine flow monitoring, intravenous therapy (IV), water leakage monitoring, and unmanned underwater robots through incorporation of the appropriate packaging of devices.
In steady search for optimization: the role of public and private actors in Switzerland’s political economy of adult education
Authors: Geiss Michael 
Published: May 2020

AbstractThis article reconstructs the changes in the political economy of adult education in Switzerland since the middle of the 20th century. Methodologically, the analysis is based on historical institutionalism and concentrates on path dependencies and critical junctures. It is shown that the Swiss adult education system is neither exclusively a marked-led nor a stakeholder-led regime. Instead, it is demonstrated that the current situation cannot be understood without considering the several government initiatives in the context of digital change since the 1970s as well as the efforts of the private national continuing education association SVEB. The article concludes with reflections on the expected impact of the first national law on continuing education which has been enacted in 2017.
Development of a rapid test kit for SARS-CoV-2: an example of product design
Authors: Cui Zhanfeng , Chang Hong , Wang Hui , Lim Boon , Hsu Chia-Chen , Yu Yejiong , Jia Huidong , Wang Yun , Zeng Yida , Ji Mengmeng , Liu Weizhi , Inverarity Catriona , Huang Wei E. 
Published: May 2020

AbstractWe present an example of applying ‘need-driven’ product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.
Sexual attraction and experiences in the primary care setting: Examining disparities in satisfaction with provider and health self‐efficacy
Authors: Luk Jeremy W. , Parker Elizabeth O. , Richardson Laura P. , McCarty Carolyn A. 
Published: May 2020

ABSTRACTIntroductionTo test whether sexual minority males and females report lower satisfaction with primary care providers and lower health self‐efficacy relative to heterosexual males and females.MethodsData from 535 adolescents who participated in one of two randomized clinical trials conducted in a primary care setting were analyzed. Multiple linear regressions controlling for demographic characteristics and treatment condition were used to examine sexual attraction differences in indicators of satisfaction with provider and health self‐efficacy.ResultsSexual minority and heterosexual youth both endorsed high satisfaction with providers. Relative to heterosexual males, sexual minority males reported lower self‐efficacy in reaching their health goals. Relative to heterosexual females, sexual minority females reported lower confidence in positively impacting their own health, and lower self‐efficacy in setting goals and working actively to improve their health.ConclusionsSexual minority youth may benefit from additional support from health care providers to enhance their health self‐efficacy and reach their health goals.
Efficacy and Acceptance of a Lombard-response Device for Hypophonia in Parkinson’s Disease
Authors: Adams Scott , Kumar Niraj , Rizek Philippe , Hong Angeline , Zhang Jenny , Senthinathan Anita , Mancinelli Cynthia , Knowles Thea , Jog Mandar 
Published: May 2020

ABSTRACT:Objective:The purpose of this study was to examine the effectiveness, satisfaction, and acceptance of a low-cost Lombard-response (LR) device in a group of individuals with Parkinson’s disease (IWPD) and their communication partners (CPs).Method:Sixteen IWPD and hypophonia and their CPs participated in the study. The IWPD wore a LR device that included a small MP3 player (Sony Walkman) and headphones playing a multi-talker noise audio file at 80 dB during lab-based speech tasks and during their daily conversational speech over a 2-week device trial period. Outcome measures included average conversational speech intensity and scores on a questionnaire related to speech impairment, communication effectiveness, and device satisfaction.Results:Conversational speech intensity of the IWPD is increased by 7 to 10 dB with the LR device. Following a 2-week trial period, eight of the IWPD (50%) gave the LR device moderate-to-high satisfaction and effectiveness ratings and decided to purchase the device for long-term daily use. At the 4-month follow-up, none of the IWPDs were still using the LR device. Device rejection was related to discomfort (loudness), headaches, interference with cognition, and difficulty controlling device.Conclusion:Short-term acceptance and satisfaction with the LR device was moderate, but long-term acceptance, beyond 4 months, was absent. Future studies are required to determine if other types of low-cost LR devices can be developed that improve long-term efficacy and device acceptance in IWPD and hypophonia.
Emergency and Disaster Preparedness at a Tertiary Medical City
Authors: AlHarastani Housam Adin M. , Alawad Yousef Ibrahim , Devi Bandana , Mosqueda Benly G. , Tamayo Vanessa , Kyoung Freiha , Abu Shaheen Amani , Sierra Shirley 
Published: May 2020

ABSTRACTObjective:The aim of this study was to evaluate the readiness of a tertiary medical cityʼs response to a disaster by assessing the hospital resources and knowledge, attitudes, practices, and familiarity of health care providers toward disaster and emergency preparedness.Methods:All KFMC (King Fahad Medical City) staff with > 1 year of clinical experience were eligible to participate in a cross-sectional study. Participants responded to the Emergency Preparedness Information Questionnaire (EPIQ), knowledge and practice questionnaires, and a disaster planning attitude checklist. Data about resources were collected using the hospital disaster preparedness self-assessment tool.Results:The overall mean knowledge score for disaster and emergency preparedness was 4.4 ± 1.1, and the mean overall familiarity score was 3.43 ± 0.97. Most participants knew that disaster drills (90.2%) and training (74.6%) are ongoing. Sixty-six (21.0%) agreed that KFMC is unlikely to experience a disaster. The highest and lowest EPIQ familiarity scores were for decontamination (83.0%) and accessing critical resources and reporting (64.3%), respectively. Most participants (99.4%) have access to work computers; however, only 53.0% used the Internet to access information on bioterrorism and/or emergency preparedness. The hospital is ready to respond in case of a disaster according to the used tool.Conclusions:The participants’ levels of knowledge, practices, and overall familiarity toward emergency and disaster preparedness were satisfactory; however, participant attitudes and familiarity with where and how to access critical resources in the event of an emergency or disaster situations require reinforcement.
Association between change in self-reported sugar intake and a sugar biomarker (δ13C) in children at increased risk for type 1 diabetes
Authors: Henze Martha M. , Bemis Elizabeth A. , Seifert Jennifer A. , Johnson Randi K. , Dong Fran , Rewers Marian , Norris Jill M. 
Published: May 2020

Abstract
We examined whether change in added sugar intake is associated with change in δ13C, a novel sugar biomarker, in thirty-nine children aged 5–10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δ13C in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake was associated with change in the δ13C biomarker, where for every 1-g increase in added sugar intake between the two time points, there was an increase in δ13C of 0⋅0082 (P = 0⋅0053), independent of change in HbA1c and δ15N. The δ13C biomarker may be used as a measure of compliance in an intervention study of children under the age of 10 years who are at increased risk for type 1 diabetes, in which the goal was to reduce dietary sugar intake.
Lichens and associated fungi from Glacier Bay National Park, Alaska
Authors: Spribille Toby , Fryday Alan M. , Pérez-Ortega Sergio , Svensson Måns , Tønsberg Tor , Ekman Stefan , Holien Håkon , Resl Philipp , Schneider Kevin , Stabentheiner Edith , Thüs Holger , Vondrák Jan , Sharman Lewis 
Published: May 2020

AbstractLichens are widely acknowledged to be a key component of high latitude ecosystems. However, the time investment needed for full inventories and the lack of taxonomic identification resources for crustose lichen and lichenicolous fungal diversity have hampered efforts to fully gauge the depth of species richness in these ecosystems. Using a combination of classical field inventory and extensive deployment of chemical and molecular analysis, we assessed the diversity of lichens and associated fungi in Glacier Bay National Park, Alaska (USA), a mixed landscape of coastal boreal rainforest and early successional low elevation habitats deglaciated after the Little Ice Age. We collected nearly 5000 specimens and found a total of 947 taxa, including 831 taxa of lichen-forming and 96 taxa of lichenicolous fungi together with 20 taxa of saprotrophic fungi typically included in lichen studies. A total of 98 species (10.3% of those detected) could not be assigned to known species and of those, two genera and 27 species are described here as new to science:Atrophysma cyanomelanosgen. et sp. nov.,Bacidina circumpulla,Biatora marmorea,Carneothele sphagnicolagen. et sp. nov.,Cirrenalia lichenicola,Corticifraga nephromatis,Fuscidea muskeg,Fuscopannaria dillmaniae,Halecania athallina,Hydropunctaria alaskana,Lambiella aliphatica,Lecania hydrophobica,Lecanora viridipruinosa,Lecidea griseomarginata,L. streveleri,Miriquidica gyrizans,Niesslia peltigerae,Ochrolechia cooperi,Placynthium glaciale,Porpidia seakensis,Rhizocarpon haidense,Sagiolechia phaeospora,Sclerococcum fissurinae,Spilonema maritimum,Thelocarpon immersum,Toensbergia blastidiataandXenonectriella nephromatis. An additional 71 ‘known unknown’ species are cursorily described. Four new combinations are made:Lepra subvelata(G. K. Merr.) T. Sprib.,Ochrolechia minuta(Degel.) T. Sprib.,Steineropsis laceratula(Hue) T. Sprib. & Ekman andToensbergia geminipara(Th. Fr.) T. Sprib. & Resl. Thirty-eight taxa are new to North America and 93 additional taxa new to Alaska. We use four to eight DNA loci to validate the placement of ten of the new species in the ordersBaeomycetales,Ostropales,Lecanorales,Peltigerales,Pertusarialesand the broader class Lecanoromycetes with maximum likelihood analyses. We present a total of 280 new fungal DNA sequences. The lichen inventory from Glacier Bay National Park represents the second largest number of lichens and associated fungi documented from an area of comparable size and the largest to date in North America. Coming from almost 60°N, these results again underline the potential for high lichen diversity in high latitude ecosystems.
Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort
Authors: Goldstein Laura H. , Robinson Emily J. , Mellers John D. C. , Stone Jon , Carson Alan , Chalder Trudie , Reuber Markus , Eastwood Carole , Landau Sabine , McCrone Paul , Moore Michele , Mosweu Iris , Murray Joanna , Perdue Iain , Pilecka Izabela , Richardson Mark P. , Medford Nick ,   on behalf of the CODES Study Group
Published: May 2020

AbstractBackgroundWe examined demographic, clinical, and psychological characteristics of a large cohort (n = 368) of adults with dissociative seizures (DS) recruited to the CODES randomised controlled trial (RCT) and explored differences associated with age at onset of DS, gender, and DS semiology.MethodsPrior to randomisation within the CODES RCT, we collected demographic and clinical data on 368 participants. We assessed psychiatric comorbidity using the Mini-International Neuropsychiatric Interview (M.I.N.I.) and a screening measure of personality disorder and measured anxiety, depression, psychological distress, somatic symptom burden, emotional expression, functional impact of DS, avoidance behaviour, and quality of life. We undertook comparisons based on reported age at DS onset (<40 v. ⩾40), gender (male v. female), and DS semiology (predominantly hyperkinetic v. hypokinetic).ResultsOur cohort was predominantly female (72%) and characterised by high levels of socio-economic deprivation. Two-thirds had predominantly hyperkinetic DS. Of the total, 69% had ⩾1 comorbid M.I.N.I. diagnosis (median number = 2), with agoraphobia being the most common concurrent diagnosis. Clinical levels of distress were reported by 86% and characteristics associated with maladaptive personality traits by 60%. Moderate-to-severe functional impairment, high levels of somatic symptoms, and impaired quality of life were also reported. Women had a younger age at DS onset than men.ConclusionsOur study highlights the burden of psychopathology and socio-economic deprivation in a large, heterogeneous cohort of patients with DS. The lack of clear differences based on gender, DS semiology and age at onset suggests these factors do not add substantially to the heterogeneity of the cohort.
Benefit of vessel closure with the Azur CX Peripheral Coil System in small children with complex CHD
Authors: Loureiro Petra , Ewert Peter , Eicken Andreas 
Published: May 2020

AbstractVessel occlusion is a frequently used procedure to close congenital or acquired collaterals or communications. We report two cases of successful vessel closure, in small infants with CHD, using the Azur CX Peripheral Coil System. The low profile of the device, the controlled delivery of the coils, and the delivery through a microcatheter make it particularly interesting for the occlusion of highly tortuous vessels in children.