bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Spine Involvement among Patients with Rheumatoid Arthritis Treated Actively with Treat-to-target Strategy: 10-year Results of the NEO-RACo Study
Authors: Sandström Tia , Rantalaiho Vappu , Yli-Kerttula Timo , Kautiainen Hannu , Malmi Timo , Karjalainen Anna , Uusitalo Tea , Julkunen Heikki , Kaipiainen-Seppänen Oili , Paimela Leena , Puolakka Kari , Uutela Toini , Möttönen Timo , Hannonen Pekka , Leirisalo-Repo Marjatta , Laasonen Leena , Kauppi Markku ,   for the NEO-RACo Study Group
Published: November 2019

Objective.To evaluate the development of radiological changes of the cervical spine in patients with rheumatoid arthritis (RA) in the NEO-RACo trial treated with an intensive, remission-targeted combination of conventional synthetic disease-modifying antirheumatic drugs (csDMARD) and additional infliximab (IFX) or placebo (PLA) for the first 6 months.Methods.Ninety-nine patients with early, DMARD-naive RA were treated with a triple combination of csDMARD and prednisolone, and randomized to double-blindly receive either IFX (FIN-RACo+IFX) or PLA (FIN-RACo+PLA) infusions during the first 6 months. After 2 years the treatment strategies became unrestricted, but the treatment goal was strict NEO-RACo remission. At the 10-year visit, radiographs of the cervical spine were taken of 85 patients (38 in the FIN-RACo+IFX group and 47 in the FIN-RACo+PLA group). The study was registered atClinicalTrials.gov(NCT 00908089).Results.There were 4/85 patients (4.7%) with cervical spine involvement (CSI) by 10 years. Atlantoaxial subluxation was found in 2/85 patients (2.4%), both in the FIN-RACo+IFX group, and none in the FIN-RACo+PLA group. Atlantoaxial impaction was found in 1/85 patients (1.2%) in the FIN-RACo+IFX group. Subaxial subluxation was found in 1/85 patients (1.2%).Conclusion.Early and intensive remission-targeted treatment has reduced the incidence of CSI and our results show that intensive treatment also prevents its development in the long run.
Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms
Authors: Tritsch Sarah R. , Encinales Liliana , Pacheco Nelly , Cadena Andres , Cure Carlos , McMahon Elizabeth , Watson Hugh , Porras Ramirez Alexandra , Mendoza Alejandro Rico , Li Guangzhao , Khurana Kunal , Jaller-Raad Juan Jose , Castillo Stella Mejia , Barrios Taborda Onaldo , Jaller-Char Alejandro , Echavez Lil Avendaño , Jiménez Dennys , Gonzalez Coba Andres , Alarcon Gomez Magda , Ariza Orozco Dores , Bravo Eyda , Martinez Victor , Guerra Brenda , Simon Gary , Firestein Gary S. , Chang Aileen Y. 
Published: November 2019

Objective.To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus (CHIKV) in a Latin American cohort.Methods.A cross-sectional followup of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having CHIKV during the 2014–2015 epidemic, and baseline and followup symptoms at 40 months were evaluated in serologically confirmed cases.Results.Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for CHIKV infection had persistent joint pain 3 years after infection. Participants who followed up in person were predominantly adult (mean ± SD age 51 ± 14 yrs) and female (86%). The most common type of pain reported in these patients at 40 months post-infection was pain with periods of relief and subsequent reoccurrence, and over 75% reported stiffness after immobility, with 39% experiencing morning stiffness.Conclusion.To our knowledge, this is the first report to describe persistent joint pain and stiffness 40 months after viral infection. The high frequency of chronic disease highlights the need to develop prevention and treatment methods. Further studies should be conducted to understand the similarities between post-chikungunya joint pain and rheumatoid arthritis.
Choisir le risque : l’autonomie du malade en situation d’échec thérapeutique
Authors: Besle Sylvain , Sarradon-Eck Aline 
Published: November 2019

L’article porte sur les situations de patients atteints de cancers avancés qui utilisent pour se soigner des traitements expérimentaux dont la balance bénéfice-risque est incertaine. Il s’appuie sur une étude de cas d’un patient qui a eu recours, à de nombreuses reprises, à des médicaments hors AMM et à des essais cliniques. En retraçant son parcours pour obtenir ces traitements innovants, l’article analyse son engagement volontaire dans des démarches expérimentales risquées que l’on peut comparer à un pari de Pascal fondé sur l’espoir. Cette comparaison nous permet de mieux comprendre comment cette détermination à lutter contre la maladie a été reçue par les professionnels de santé dans le contexte de la cancérologie moderne. Ce travail donne une lecture du recours à des traitements « risqués » en le considérant en tant que source d’une forme d’autonomie des patients au moment où les connaissances médicales standard ne suffisent plus à prolonger la vie.
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor–Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes
Authors: Hedl Matija , Sun Rui , Huang Chen , Abraham Clara 
Published: November 2019

Abstract
Genetic variants in the STAT3/STAT5A/STAT5B region are associated with immune-mediated diseases, including inflammatory bowel disease (IBD). However, how STAT3 and STAT5 regulate the critical balance between pro- and anti-inflammatory cytokines and how common disease-associated genetic variants (e.g., rs12942547) in the region modulate this balance are incompletely understood. We found that upon pattern-recognition receptor (PRR) stimulation of human monocyte-derived macrophages (MDMs), decreasing STAT3, STAT5a, and STAT5b expression led to a progressive decrease in anti-inflammatory cytokines, whereas proinflammatory cytokines initially decreased but then increased when STAT3 or STAT5 expression fell below a critical threshold. Mechanisms regulating STAT3- and STAT5-dependent inflammatory cytokine outcomes included negative feedback from autocrine/paracrine IL-10, TGF-β, IL-4, IL-13, IL-22, and TSLP secretion and SOCS1/SOCS2/SOCS3 induction. MDMs from rs12942547 AA disease-risk carriers demonstrated increased STAT3, STAT5a, and STAT5b expression and increased PRR-induced STAT3 and STAT5 phosphorylation relative to GG MDMs. Both pro- and anti-inflammatory cytokine secretion was decreased in MDMs from GG carriers, as STAT3, STAT5a, and STAT5b expression was above the threshold for reciprocal regulation of these cytokines. Taken together, we identify that the threshold of STAT3, STAT5a, and STAT5b expression determines if PRR-induced proinflammatory cytokines are increased or decreased, define mechanisms for this reciprocal regulation, and elucidate consequences for disease variants in the STAT3/STAT5A/STAT5B region, indicating that considering signaling thresholds and targeting specific cell types might be beneficial when evaluating therapeutic interventions in this pathway.
Targeting the Immune Complex–Bound Complement C3d Ligand as a Novel Therapy for Lupus
Authors: Kulik Liudmila , Laskowski Jennifer , Renner Brandon , Woolaver Rachel , Zhang Lian , Lyubchenko Taras , You Zhiying , Thurman Joshua M. , Holers V. Michael 
Published: November 2019

Abstract
Humoral autoimmunity is central to the development of systemic lupus erythematosus (SLE). Complement receptor type 2 (CR2)/CD21 plays a key role in the development of high-affinity Abs and long-lasting memory to foreign Ags. When CR2 is bound by its primary C3 activation fragment–derived ligand, designated C3d, it coassociates with CD19 on B cells to amplify BCR signaling. C3d and CR2 also mediate immune complex binding to follicular dendritic cells. As the development of SLE involves subversion of normal B cell tolerance checkpoints, one might expect that CR2 ligation by C3d-bound immune complexes would promote development of SLE. However, prior studies in murine models of SLE using gene-targeted Cr2−/− mice, which lack both CR2 and complement receptor 1 (CR1), have demonstrated contradictory results. As a new approach, we developed a highly specific mouse anti-mouse C3d mAb that blocks its interaction with CR2. With this novel tool, we show that disruption of the critical C3d–CR2 ligand-receptor binding step alone substantially ameliorates autoimmunity and renal disease in the MRL/lpr model of SLE.
Products of Involutions of an Infinite-dimensional Vector Space
Authors: de Seguins Pazzis Clément 
Published: November 2019

AbstractWe prove that every automorphism of an infinite-dimensional vector space over a field is the product of four involutions, a result that is optimal in the general case. We also characterize the automorphisms that are the product of three involutions. More generally, we study decompositions of automorphisms into three or four factors with prescribed split annihilating polynomials of degree $2$.
Dosage in Preventative OT Interventions With Community-Dwelling Older Adults
Authors: Schelly David , Nadres Ramona , Ohl Alisha 
Published: November 2019

Abstract
Date Presented 04/05/19
This research considered attendance in the Well Elderly II intervention to determine the dosage effect on depression scores. In particular, how many hours of OT sessions are necessary to produce meaningful reductions in depressive symptoms? Our analysis suggests that the small improvements in depression scores do not appear to be associated with the dosage of the intervention received; therefore, any preventative effects of the intervention need to be reconsidered.
Primary Author and Speaker: David Schelly
Additional Authors and Speakers: Ramona Nadres, Alisha Ohl
A Follow-Up Study of Injury Prevention for Computer Workers Through Ergonomic Education: A Descriptive Study
Authors: Maxwell Jessica , Howell Dana , Causey-Upton Renee 
Published: November 2019

Abstract
Date Presented 04/05/19
As an ergonomic intervention follow-up, this study will be important as it shows that ergonomic assessments are substantial in producing prolonged health and wellness, increased knowledge of ergonomics, and workstation safety in order to further reduce risk for injury for computer workers. It also demonstrates OT’s ability to sustain ergonomic programs over a period of time to improve worker safety.
Primary Author and Speaker: Jessica Maxwell
Additional Authors and Speakers: Dana Howell, Renee Causey-Upton
Preventing Aspiration Complications: Implementing a Swallow Screening Tool
Authors: Pifer Gina , Hatlevig Janelle , Wangen Tina , Vitale Kirsten 
Published: November 2019

Abstract
Date Presented 04/05/19
There is a clear need for improved clinical identification of all acutely ill hospitalized patients at risk for aspiration. In 2016, a 1,100-bed quaternary-care facility found an upward trend in mortality rates with diagnoses of aspiration from years 2013 to 2015. An aspiration risk screening process was implemented to increase timely involvement of a dysphagia therapist. Current mortality data indicates that this change increases patient safety by timely involvement of dysphagia therapists.
Primary Author and Speaker: Gina Pifer
Additional Authors and Speakers: Janelle Hatlevig
Contributing Authors: Tina Wangen, Kirsten Vitale
Feasibility of a Community-Based OT-Led Life-Management Intervention for Individuals With Stroke
Authors: Hill Valerie , Miller Valerie , Towfighi Amytis 
Published: November 2019

Abstract
Date Presented 04/05/19
The purpose of the study was to develop and evaluate the feasibility of a culturally tailored, community-based life management intervention to improve quality of life and mitigate stroke risk factors in 10 individuals after experiencing a stroke. The intervention was feasible in this sample with positive outcomes for participant retention and attendance; engagement in meaningful activities; stroke-related quality of life; reintegration to normal living; and healthy behavior changes.
Primary Author and Speaker: Valerie Hill
Additional Authors and Speakers: Valerie Miller
Contributing Authors: Amytis Towfighi
Social Participation Among Adults With Disability
Authors: Liu John 
Published: November 2019

Abstract
Date Presented 04/05/19
The aim of this study is to determine the correlates of social participation among older adults with disability. Participation in social activities is associated with improved health. Initial findings show that social participation is associated with mobility. This can be used as evidence to advocate for clients to receive necessary services to improve their social participation. Such evidence can be used in practice and possible policy formulation.
Primary Author and Speaker: John Liu
Interventions Addressing Injury Among Agricultural Workers: A Systematic Review
Authors: Volkmer Katrin , Molitor Whitney Lucas 
Published: November 2019

Abstract
Date Presented 04/05/19
Agricultural injuries lead to loss of work time and resultant negative effects for physical and mental health. Limited published research exists regarding the efficacy of OT intervention to mitigate or prevent such injuries. A systematic review exploring such interventions for management or prevention of agriculture-related injuries reveals that musculoskeletal interventions along with environmental modifications and client education are supported by evidence.
Primary Author and Speaker: Katrin Volkmer
Additional Authors and Speakers: Whitney Lucas Molitor
Quality of Life in Families With a Young Child With Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection (PANDAS)
Authors: Demchick Barbara , Ehler Julia , Marramar Shelly , Mills Alison , Nuneviller Amanda 
Published: November 2019

Abstract
Date Presented 04/05/19
PANDAS is the abrupt onset of OCD or tics after streptococcal infection in a formerly healthy child. We used qualitative phenomenology to explore family quality of life (FQOL) in six families with a child who developed PANDAS in early childhood. Data were collected through interviews, which were transcribed and analyzed through a rigorous inductive process. Results indicate that PANDAS severely impacts FQOL, and OT's awareness of PANDAS may be key to supporting the child and family.
Primary Author and Speaker: Barbara Demchick
Additional Authors and Speakers: Julia Ehler, Shelly Marramar, Alison Mills, Amanda Nuneviller
Perspectives of OTs Regarding Use of Standardized Assessments To Distinguish Levels of Evaluation in a Skilled-Nursing Facility
Authors: Victor Callie , Krutis Susan , Chandler Erica , Chang Beth , Cherry Whitney , Doughty Paige , Hubka Danielle , Murphy Kaitlin , Zepf Zach 
Published: November 2019

Abstract
Date Presented 04/05/19
This study explored perspectives of OTs at a skilled-nursing facility regarding the use of standardized assessments during patient evaluation. Study results revealed that clinical observations are the chosen method of evaluation to support billing procedures using new CPT codes. Participants indicated that despite the value of objective measurements, they cannot ignore the pressures of time and productivity.
Primary Author and Speaker: Callie Victor
Additional Authors and Speakers: Susan Krutis
Contributing Authors: Erica Chandler, Beth Chang, Whitney Cherry, Paige Doughty, Danielle Hubka, Kaitlin Murphy, Zach Zepf
Systematic Overview of Neuroanatomical Differences in ADHD: Definitive Evidence
Authors: Vieira de Melo Bruno , Trigueiro Maria João , Rodrigues Pedro 
Published: November 2019

Abstract
Date Presented 04/05/19
Neuroanatomical differences in ADHD is one of the most investigated topics. Therefore, we aimed to identify these differences through the first published Systematic Overview of Systematic Reviews, using Cochrane guidelines and PRISMA to criteria. We propose a hypothesis of an unbalanced multinetwork neurofunctioning and the scientific evidence that OT must be integrated in primary-care teams to assess how a multiskill involvement impacts functional and occupational performance.
Primary Author and Speaker: Bruno Vieira de Melo
Contributing Authors: Maria João Trigueiro, Pedro Rodrigues
The Lived Experiences of Equine-Assisted Activities and Therapies (EAAT) on Veterans With Posttraumatic Stress Disorder (PTSD)
Authors: Bloch Elise , Franklin Ashni , Kramer Zoey , Padua Gianina 
Published: November 2019

Abstract
Date Presented 04/05/19
This presentation will review findings from a phenomenological study conducted by graduate MOT students to explore the lived experiences of veterans with PTSD participating in equine-assisted activities and therapies (EAAT). Veterans found that this nontraditional treatment provided safety, healing, and meaning to their lives, along with establishing new routines and skills, without the stigma associated with mainstream treatment. Study limitations and future research recommendations will be discussed.
Primary Author and Speaker: Elise Bloch
Additional Authors and Speakers: Zoey Kramer
Contributing Authors: Ashni Franklin, Gianina Padua
OT in an Equine Environment for Children With Autism: A Multiple Baseline Single-Case Experimental Design
Authors: Peters B. Caitlin , Wood Wendy 
Published: November 2019

Abstract
Date Presented 04/05/19
Results of this single-case experimental design indicate that children with autism who participated in OT in an equine environment demonstrated improvement in individual occupational performance goals, social motivation, and social communication. Some, but not all, participants demonstrated decreased irritability and hyperactivity. Results suggest that horses and the equine environment can be effectively integrated into OT for children with autism.
Primary Author and Speaker: B. Caitlin Peters
Contributing Authors: Wendy Wood
Self-Determination and Employment Supports: Enabling Career Development and Integrated Employment
Authors: Dean Evan 
Published: November 2019

Abstract
Date Presented 04/05/19
For transition-age young adults with autism spectrum disorder (ASD), employment represents a key component of participation. This presentation will report preliminary outcomes of a study using the SDCDM. We found that the SDCDM can have a positive impact on the career development of young adults with ASD. Specifically, participants saw gains in goal attainment, which moved them closer to their long-term employment goals.
Primary Author and Speaker: Evan Dean
Promote Sleep: An Environmental Sleep Tool Kit for Elderly Veterans
Authors: Dusek Siri , Hynes Alissa , Frie Brenda , Benz Janet , Graham Cynthia , Campbell Katherine , Bonsell Laura , Heinen Lecia , Mehelich Mary , Kelvie Mary 
Published: November 2019

Abstract
Date Presented 04/05/19
Primary Author and Speaker: Siri Dusek
Additional Authors and Speakers: Alissa Hynes, Brenda Frie
Contributing Authors: Janet Benz, Cynthia Graham, Katherine Campbell, Laura Bonsell, Lecia Heinen, Mary Mehelich, Mary Kelvie
Activity and Participation Levels During and After Cardiac Rehabilitation Program in People With Cardiac Conditions: Prospective Observational Study
Authors: Kim Young Joo , Crane Patricia , Houmard Joseph , Swift Damon , Reeve Jonathan , Walters Deena , Young Molly 
Published: November 2019

Abstract
Date Presented 04/06/19
This prospective observational study investigates the changes people with chronic cardiac conditions may experience after discharged from cardiac rehabilitation. The findings advance OT practitioners’ knowledge on short-term and long-term changes in physical activity and participation level, cognition, motivation, and fatigue and understanding of OT roles for people with chronic cardiac conditions who are postacute and postcardiac rehabilitation.
Primary Author and Speaker: Young Joo Kim
Additional Authors and Speakers: Jonathan Reeve, Deena Walters, Molly Young
Contributing Authors: Patricia Crane, Joseph Houmard, Damon Swift
Influence of Environmental Factors on Social Participation Poststroke
Authors: Foley Erin , Connor Lisa , Nicholas Marjorie , Baum Carolyn 
Published: November 2019

Abstract
Date Presented 04/06/19
This poster describes a study that examined the extent to which environmental factors affected participation in social activities for individuals at least six months poststroke. Results of the study provide OTs with a better understanding of important environmental factors to consider when addressing social participation after stroke and help to expand the focus of the rehabilitation literature beyond body functions and structures to participation in meaningful activities.
Primary Author and Speaker: Erin Foley
Additional Authors and Speakers: Lisa Connor
Contributing Authors: Marjorie Nicholas, Carolyn Baum
Sensory Processing and Internalizing Behaviors in Children: A Scoping Review
Authors: Kotsiris Kasey , Little Lauren 
Published: November 2019

Abstract
Date Presented 04/06/19
This scoping review examined research on the association between sensory processing and internalizing behavior among individuals ages 1-22 years. Findings suggest that sensory processing sensitivity was positively associated with various conditions, personality characteristics, aspects of family life, anxiety, and mental health difficulties. Findings from this scoping review may inform intervention approaches that target the sensory processing underpinnings of internalizing behaviors.
Primary Author and Speaker: Kasey Kotsiris
Additional Authors and Speakers: Lauren Little
Emergence of Self-Efficacy (SE) During Psychoeducational Group Meetings and Discussions for Undergraduates With Learning and Attention Disorders
Authors: Kreider Consuelo , Apostol Jianne , Lan Mei-Fang , Wu Chang-Yu , Percival Susan , Byrd Charles 
Published: November 2019

Abstract
Date Presented 04/06/19
Self-efficacy (SE) is critical to the success of students with learning and attention disorders (L/AD). Research describes processes for development of SE in undergraduates for identifying and obtaining the information, resources, and skills needed to bolster college-role success. Fifty-two undergraduates with L/AD engaged in psychoeducational groups; data were 30 transcripts from group discussions. A process model of SE development was developed from the data.
Primary Author and Speaker: Consuelo Kreider
Additional Authors and Speakers: Jianne Apostol
Contributing Authors: Mei-Fang Lan, Chang-Yu Wu, Susan Percival, Charles Byrd
The Effectiveness of Routine OT Interventions on Motor Skills for Children With Developmental Coordination Disorder (DCD)
Authors: Piller Aimee , Kohnert Lindsey 
Published: November 2019

Abstract
Date Presented 04/06/19
This study provides a retrospective pre- and posttest study examining the routine practice of OT in the treatment of developmental coordination disorder (DCD). The study provides an example of practice-based evidence in examining medical records of children with DCD who received OT services. The study presents the effectiveness of OT services on improving motor skills of children with DCD.
Primary Author and Speaker: Aimee Piller
Additional Authors and Speakers: Lindsey Kohnert, Lindsey Kohnert, Lindsey Kohnert