bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal regional homogeneity and its relationship with symptom severity in cervical dystonia: A rest state fMRI study
Authors: Wei Shubao , Lu Chunhui , Chen Xiuqiong , Yang Lu , Wei Jing , Jiang Wenyan , Liu Yang , Li Huihui , Qin Yuhong , Lei Yiwu , Qin Chao , Hu Caiyou , Luo Shuguang 
Published: December 2020

Abstract
Background: Although several brain networks play important roles in cervical dystonia (CD) patients, regional homogeneity (ReHo) changes in CD patients have not been clarified. We investigated to explore ReHo in CD patients at rest and analyzed its correlations with symptom severity as measured by Tsui scale.Methods: A total of 19 CD patients and 21 gender-, age-, and education-matched healthy controls underwent fMRI scans at rest state. Data were analyzed by ReHo method.Results: Patients showed increased ReHo in the right cerebellum crus I and decreased ReHo in the right superior medial prefrontal cortex (MPFC). Moreover, the right precentral gyrus, right insula, and bilateral middle cingulate gyrus also showed increased ReHo values. A significantly positive correlation was observed between ReHo value in the right cerebellum crus I and symptom severity (p < 0.05).Conclusions: Our investigation suggested abnormal ReHo existed in brain regions of the "pain matrix" and salience network (the right insula and bilateral middle cingulate gyrus), the motor network (the right precentral gyrus), the cerebellum and MPFC and further highlighted the significance of these networks in the pathology of CD.
Statistical analysis of ionospheric total electron content (TEC): Long-term estimation of extreme TEC in Japan
Authors: Nishioka Michi , Saito Susumu , Tao Chihiro , Shiota Daikou , Tsugawa Takuya , Ishii Mamoru 
Published: December 2020

Abstract
Ionospheric total electron content (TEC) is one of the key parameters for users of radio-based systems, such as the Global Navigation Satellite System, high-frequency communication systems, and space-based remote sensing systems, since total ionospheric delay is proportional to TEC through the propagation path. It is important to know extreme TEC values in readiness for hazardous ionospheric conditions. The purpose of this study is to estimate extreme TEC values with occurrences of once per year, ten years, and hundred years in Japan. In order to estimate the extreme values of TEC, a cumulative distribution function of daily TEC is derived using 22 years of TEC data from 1997 to 2018. The extreme values corresponding to once per year and ten years are 90 and 110 TECU, respectively, in Tokyo, Japan. On the other hand, the 22-year data set is not sufficient to estimate the once-per-hundred-year value. Thus, we use the 62-year data set of manually scaled ionosonde data for the critical frequency of the F-layer (foF2) at Kokubunji in Tokyo. First, we study the relationship between TEC and foF2 for 22 years and investigate the slab thickness. Then the result is applied to the statistical distribution of foF2 data for 62 years. The result shows that the once-per-100-year TEC is about 130-190 TECU at Tokyo. The value is also estimated to be 160-230 TECU in Kagoshima and 100-150 TECU in Hokkaido, in the southern and northern parts of Japan, respectively.
Geomagnetic secular variation forecast using the NASA GEMS ensemble Kalman filter: A candidate SV model for IGRF-13
Authors: Tangborn Andrew , Kuang Weijia , Sabaka Terence , Ye Ce 
Published: December 2020

Abstract
We have produced a 5-year mean secular variation (SV) of the geomagnetic field for the period 2020-2025. We use the NASA Geomagnetic Ensemble Modeling System (GEMS), which consists of the NASA Goddard geodynamo model and ensemble Kalman filter (EnKF) with 400 ensemble members. Geomagnetic field models are used as observations for the assimilation, including gufm1 (1590-1960), CM4 (1961-2000) and CM6 (2001-2019). The forecast involves a bias correction scheme that assumes that the model bias changes on timescales much longer than the forecast period, so that they can be removed by successive forecast series. The algorithm was validated on the time period 2010-2015 by comparing with CM6 before being applied to the 2020-2025 time period. This forecast has been submitted as a candidate predictive model of IGRF-13 for the period 2020-2025.
Increased Frequency of β Cells with Abnormal NKX6.1 Expression in Type 2 Diabetes but not in Subjects with Higher Risk for Type 2 Diabetes
Authors: Liu Tengli , Sun Peng , Zou Jiaqi , Wang Le , Wang Guanqiao , Liu Na , Liu Yaojuan , Ding Xuejie , Zhang Boya , Liang Rui , Wang Shusen , Shen Zhongyang 
Published: December 2020

Abstract
Background: NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6.1 expression in β cells, such as translocation from the nucleus to cytoplasm or lost expression, has been shown as a marker for β cell dedifferentiation. Methods: Here, we obtained pancreata sections from organ donors, and aim to characterize NKX6.1 expression in subjects with or without type 2 diabetes mellitus (T2DM), and NKX6.1 and insulin immunofluorescence staining was performed. Results: Our results showed that cells with insulin expression but no nucleic NKX6.1 expression (NKX6.1Nuc-Ins+), and cells with cytoplasmic NKX6.1 expression but no insulin expression (NKX6.1cytIns-) were significantly increased in T2DM subjects and positively correlated with glycated hemoglobin (HbA1c), indicating the elevated β cell dedifferentiation with NKX6.1 inactivation in T2DM. To investigate whether β cell dedifferentiation has initiated in subjects with higher risks for T2DM, we next analyzed the association between β-cell dedifferentiation level in ND subjects with different ages, body mass index, and HbA1c. The results showed the absolute number and percentage of dedifferentiated β cells with NKX6.1 inactivation did not significantly change in subjects with advanced aging, obesity, or modest hyperglycemia, indicating that the β cell dedifferentiation may mainly occur after T2DM was diagnosed. Conclusion: In sum, our results suggested that NKX6.1 expression in β cells is changed in type 2 diabetic subjects, evidenced by significantly increased NKX6.1Nuc-Ins+ and NKX6.1cytIns- cells. This abnormality does not occur more frequently in subjects with a higher risk for T2DM, suggesting that β cell dedifferentiation might be secondary to the pathological changes in T2DM.
Evaluation of 18F-FDG PET/CT Images Acquired with a Reduced Scan Time Duration in Lymphoma Patients using the Digital Biograph Vision
Authors: Weber Manuel , Jentzen Walter , Hofferber Regina , Herrmann Ken , Fendler Wolfgang Peter , Rischpler Christoph , Umutlu Lale , Conti Maurizio , Costa Pedro Fragoso , Sra Miriam , Kersting David 
Published: December 2020

Abstract
Background

The superior accuracy and sensitivity of 18 F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce administered tracer activity or scan time duration while maintaining diagnostic performance; this might allow for a higher patient throughput or a reduced radiation exposure, respectively. In particular, the radiation exposure reduction is of interest due to the often young age and high remission rate of lymphoma patients.

Methods

Twenty patients with (suspected) lymphoma (6 for initial staging, 12 after systemic treatment, 2 in suspicion of recurrence) sequentially underwent 18 F-FDG-PET/CT examinations on a digital PET/CT (Siemens Biograph Vision) with a total scan time duration of 15 minutes (reference acquisition protocol) and 5 minutes (reduced acquisition protocol) using continuous-bed-motion. Both data sets were reconstructed using either standalone time of flight (TOF) or in combination with point spread function (PSF), each with 2 and 4 iterations. Lesion detectability by blinded assessment (separately for supra- and infradiaphragmal nodal lesions and for extranodal lesions), lesion image quantification, and image noise were used as metrics to assess diagnostic performance. Additionally, Deauville Score was compared for all patients after systemic treatment.

Results

All defined regions were correctly classified in the images acquired with reduced emission time, and therefore, no changes in staging were observed. Lesion quantification was acceptable, that is, mean absolute percentage deviation of maximum and peak standardized uptake values were 6.8% and 6.4% (derived from 30 lesions). A threefold reduction of scan time duration led to an increase in image noise from 7.1% to 11.0% (images reconstructed with 4 iterations) and from 4.7% to 7.2% (images reconstructed with 2 iterations). No deviations in Deauville Score were observed.

Conclusion

These results suggest that scan time duration or administered tracer activity can be reduced threefold without compromising diagnostic performance. Especially a reduction of administered activity might allow for a lower radiation exposure and better health economics. Larger trials are warranted to confirm our results.
Breast Cancer in Togolese Women: Immunohistochemistry Subtypes
Authors: ADANI-IFE Ablavi , AMEGBOR Koffi , DOH Kwamé , DARRE Tchin 
Published: December 2020

Abstract
Background: Molecular classification of breast cancer is an important factor for prognostic and clinical outcomes. There are no data regarding molecular breast cancer subtypes among Togolese women. The objective of this study was to evaluate the expression of ER, PR, HER2, and molecular subtypes of breast cancer receptors in Togolese patients and to establish the correlation between clinical and histological data and molecular types. Methods: Clinicopathologic data of patients were collected from clinical records. Immunohistochemistry biomarkers (ER, PR, and HER2) were assessed in patients who have been diagnosed with invasive breast cancer from March 2016 to March 2020 in the department of oncology. The analysis of variance and the Chi-square Test was used to analyze the data. Results: A total of 117 cases were collected. The mean age of patients was 52.05±12.38 with an age range of 30 to 85 years. Half of the patients were over 50 years old and the majority (70.9%) was postmenopausal. More than half of patients (52.1%) presented with T3-T4tumors.The most common histologic subtype of breast cancer was invasive ductal carcinoma of no special type (95.7%). Tumors grade 2 were predominant (51.3%) followed by grade 3 (42.7%). Advanced carcinomas were found in 69 patients (59%). The percentage of ER+, PR+, and HER2 positive tumors was 54.7%, 41%, and 15.4% respectively. The predominant molecular subtype was Triple negative (37.6%), followed by Luminal A (30.8.7%), Luminal B subtype (23.9%), and HER2 enriched (7.7%). There was a significant association between stage and breast cancer subtypes (p 0.025), histologic grade, and subtype (p<0.0001) but no correlation was found with age, menopausal status, and tumor size. Conclusion: Breast carcinoma in our patients are high grade tumors and are diagnosed at an advanced stage. Triple negative and Luminal A are the two predominant breast cancer subtypes in Togolese women. Consequently, Receptor testing availability should be a priority to offer the best breast cancer treatment.
Subcutaneous ticks: first report in a golden jackal and their absence in non-canid carnivores
Authors: Mechouk Noureddine , Deak Georgiana , Ionica Angela Monica , Ionescu Dan Traian , Chisamera Gabriel Bogdan , Gherman Calin Mircea , Mihalca Andrei Daniel 
Published: December 2020

Abstract
Background: Ticks are hematophagous arthropods which normally attach to the surface of the skin of the host. Their aberrant presence in the subcutaneous tissue of a few carnivores, predominantly foxes has been reported. However, there are no reports in other carnivores such as mustelids or golden jackals. Our aim was to investigate and broaden the host spectrum for this aberrant localization of ticks.Methods: Between 2015 and 2020, 198 carnivore carcasses from 12 species were examined by parasitological necropsy. When subcutaneous ticks were found, the nodules were removed, carefully dissected, and stored in ethanol. The morphological identification of the subcutaneous ticks was carried out to the species level.Results: A single subcutaneous tick was found in one carcass, a golden jackal. The tick was identified as a female Ixodes ricinus. All the other carcasses were negative for the presence of subcutaneous ticks.Conclusion: The present paper represents the first report of a subcutaneous tick in a golden jackal (Canis aureus), extends the host spectrum for this unusual phenomenon and reinforces its presence only in canids among carnivores.
Validation of Computed Extreme Ultraviolet Emission Spectra During Solar Flares
Authors: Nishimoto Shohei , Watanabe Kyoko , Kawai Toshiki , Imada Shinsuke , Kawate Tomoko 
Published: December 2020

Abstract
X-rays and extreme ultraviolet (EUV) emissions from solar flares rapidly change the physical composition of the Earth’s thermosphere and ionosphere, thereby causing space weather phenomena such as communication failures. To predict the effects of flare emissions on the Earth’s upper atmosphere, numerous empirical and physical models have been developed. We verify the extent of reproducing the flare emission spectra using a one-dimensional hydrodynamic calculation and the CHIANTI atomic database. To verify the proposed model, we use the observed EUV spectra obtained by the extreme ultraviolet variability (EVE) on board the Solar Dynamics Observatory (SDO). We examined the “EUV flare time-integrated irradiance” and “EUV flare line rise time” of the EUV emissions for 21 events by comparing the calculation results of the proposed model and observed EUV spectral data. The proposed model succeeded in reproducing the EUV flare time-integrated irradiance of the Fe VIII 131 Å , Fe XVIII 94 Å, and Fe XX 133 Å, as well as the 55 to 355 Å and 55 to 135 Å bands. For the EUV flare line rise time, there was acceptable correlation between the proposed model estimations and observations for all Fe flare emission lines. These results demonstrate that the proposed model can reproduce the EUV flare emission spectra from the emitting plasma with relatively high formation temperature. This indicates that the physics-based model is effective for the accurate reproduction of EUV spectral flux.
Energy-Efficient Time and Energy Resource Allocation in Non-selfish Symbiotic Cognitive Relaying Sensor Network with Privacy Preserving for Smart City
Authors: Li Ping , Liu Yu , Gao Xiang , Li Huibo , Gong Peng 
Published: December 2020

Abstract
Energy efficiency and privacy preserving have become essential for the wireless sensor networks. In this paper, a joint energy and time resource allocation problem for the cognitive users (CUs) in a non-selfish symbiotic cognitive relaying scheme (NSCRS) is considered. We aim to maximize the total energy efficiency (EE) of the primary user and cognitive users with the consideration of information privacy under the total energy constraints of cognitive users. With full channel state information (CSI), an optimal energy and time resource allocation algorithm is proposed based on the exhaustive searching. Besides, in order to reduce the overhead of CSI feedback, a suboptimal algorithm, in which only the partial instantaneous CSI is required, is additionally proposed. Simulation results demonstrate the energy efficiency of primary and cognitive users in the NSCRS with consideration of information privacy can be greatly improved by the proposed algorithms.
Tuberculosis (TB) in the refugee camps in Ethiopia: Trends of case notification, profile, and treatment outcomes, 2014 to 2017
Authors: Legesse Tsegay , Admenur Goitom , Gebregzabher Selemawit , Woldegebriel Eyob , Fantahun Bexabeh , Tsegay Yemane , Bayssa Abeyot , Darge Berihu , Denbu Yidnekachew , Michalel Hayelom , Abera Kibebew , Alemayeh Abraham , Kebede Dejene , Kassa Desta 
Published: December 2020

Abstract
Background: Severity of TB increases in refugee populations. Monitoring TB case notification and treatment outcomes are essential to improve the effectiveness of TB programs. This study aimed to investigate trends in TB case notification and treatment outcomes and explore factors associated with unsuccessful treatment outcome in refugee camps in Ethiopia. Methods: In this retrospective cohort study, demographic and clinical data of all TB cases registered in 25 refugee camps in Ethiopia from January 2014 to December 2017 were extracted. Multivariate logistic regression was fitted to estimate odds ratios and corresponding 95% confidence intervals for the measure of association linked with factors significantly associated with unsuccessful treatment outcomes. Results: A total of 1553 TB cases, mean age 27.7 years, were registered from 2014 to 2017. Of these notified cases 54.7% were men, 27.7% children (< 15 years), 71.2% pulmonary TB (PTB), 27.8% Extra-PTB (EPTB) and 98.3% new and relapse. From 2014 to 2017: there was consistent increase in number of notified TB cases (138 to 588 cases), in percentage of EPTB (23.2% to 32.7%), in contribution of children to total TB cases (18.8% to 30.1%) and to EPTB (40.6% to 65.1%), and in proportion of bacteriologically confirmed new and relapse pulmonary cases (43.8% to 64.8%). Treatment success rates for all TB cases remained lower at 72.7%-79.4%. On average 24.8% had unfavorable treatment outcome, including 11.5% not evaluated, 8.0% LTFU, 4.8% died and 0.5% treatment failed. Unsuccessful treatment was significantly associated with pretreatment weight below 40 Kg, age over 45 years, and being HIV positive. Conclusions: There was continuous increase in notified TB cases and in percentage of childhood TB. Proportion of bacteriologically confirmed new and relapse pulmonary cases increased overtime. TB treatment success remained lower than the national achievement in 2017 (96%) and global target (>=90%), which needs improvement. The higher LTFU, not evaluated, and death suggests the need to strengthen adherence education and supervision. Special socio-economic support and monitoring is required for patients with pretreatment weight below 40 Kg, age over 45 years and HIV positives.
A retrospective quantitative implementation evaluation of Safer Opioid Prescribing, a Canadian continuing education program
Authors: Sud Abhimanyu , Doukas Kathleen , Hodgson Katherine , Hsu Justin , Miatello Amber , Moineddin Rahim , Paton Morag 
Published: December 2020

Abstract
BackgroundContinuing health professions education (CHPE) is an important policy intervention for the opioid epidemic. Besides effectiveness or impact, health policy implementation should be studied to understand how an intervention was delivered within complex environments. Implementation outcomes can be used to help interpret CHPE effects and impacts, help answer questions of “how” and “why” programs work, and inform transferability. We evaluated Safer Opioid Prescribing (SOP), a national CHPE program, along the implementation outcomes of reach, dose, fidelity, and participant responsiveness.MethodsWe conducted a retrospective quantitative implementation evaluation of the 2014-2017 cohorts of SOP. To measure reach and dose, we examined participation and completion data. We used Ontario physician demographic data, including regulatory status with respect to controlled substances, to examine relevant trends. To measure fidelity and participant responsiveness, we analyzed participant-provided evaluations of bias, active learning, and relevance to practice. We used descriptive statistics and measures of association for both continuous and categorical variables. We used logistic regression to determine predictors of workshop participation and analysis of covariance to examine variation in satisfaction across different-sized sessions.ResultsIn total, there were 472 unique participants, 84.0% of whom were family physicians. Among Ontario physician participants, 90.0% were family physicians with characteristics representative of province-wide demographics. Webinar completion rate was 86.2% with no differences in completion based on rurality, gender, or controlled substance prescribing status with medical regulatory authorities. Nearly all participants rated the three webinars and workshop as balanced, and each element of SOP was also rated as highly relevant to clinical practice.ConclusionsThis evaluation demonstrates that Safer Opioid Prescribing was implemented as intended. Over a short period and without any external funding, the program reached more than 1% of the Ontario physician workforce. This suggests that the program may be a good model for using virtual CHPE to reach a critical mass of prescribers to drive population-level opioid utilization changes. This study represents a methodological advance of adapting evaluation methods from health policy and complex interventions for continuing health professions education. Future studies will assess effectiveness and impact on opioid prescribing and utilization within evaluation models of complex interventions.
A practice facilitation-guided intervention in primary care settings to reduce cardiovascular disease risk: A cost analysis
Authors: Gold Heather T , Siman Nina , Cuthel Allison M , Nguyen Ann M , Pham-Singer Hang , Berry Carolyn A , Shelley Donna R 
Published: December 2020

Abstract
Background A stepped-wedge, cluster randomized controlled trial assessed the effectiveness of practice facilitation (PF) for adoption of guidelines for prevention and treatment of cardiovascular disease risk factors. This study estimated the associated cost of PF for guideline adoption in small, private primary care practices.Methods The cost analysis included categories for start-up costs, intervention costs, and practice staff costs for the implemented PF-guided intervention. We estimated the total one-year costs to operate the program, and calculated the mean and range of the cost-per-practice by quarter of the intervention. We estimated the lower and upper bounds for all salary expenses, rounding to the nearest $100. Results Total one-year intervention costs for all 261 practices ranged from $7,900,000-$10,200,000, with program and practice salaries comprising $6,600,000-$8,400,000 of the total. Start-up costs were a small proportion (3%) of total one-year costs. Excluding start-up costs, quarter 1 cost-per-practice was the most expensive at $20,400-$26,700, and quarter 4 was least expensive at about $10,000. Practice staff time (compared with program staff time) was the majority of the staffing costs at 75-84%. Conclusions The PF strategy cost approximately $10,000 per practice per quarter for program and practice costs, once implemented and running at highest efficiency. Whether this program is “worth it” to the decision-maker depends on the relative costs and effectiveness of their other options for improving cardiovascular risk reduction. Trial Registration This study is retrospectively registered on January 5, 2016 at www.clinicaltrials.gov as NCT02646488. https://clinicaltrials.gov/ct2/show/NCT02646488