bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life analysis of 280 patients with surgically treated acromegaly: a single-center experience from 2008 to 2015
Authors: Rotermund Roman , Mader Marius M. , Burkhardt Till , Matschke Jakob , Aberle Jens , Krajewski Kara , Flitsch Jörg , Rahvar Amir-Hossein 
Published: June 2020

OBJECTIVEThe purpose of this study was to analyze the clinical and biochemical outcome of consecutive patients with acromegaly after microscopic transsphenoidal surgery (MTS) at a single center over an 8-year period.METHODSA retrospective analysis of patients with acromegaly treated via MTS between 2008 and 2015 at the authors’ center was performed. The mean follow-up was 29 months (range 1–120 months). Parameters investigated included tumor size, pre- and postoperative insulin-like growth factor–I, growth hormone levels, pretreatment, perioperative complications, and clinical outcome.RESULTSA total of 280 patients with acromegaly were treated surgically at the authors’ center over the abovementioned time frame and were included in analyses. For 231 of these patients, complete follow-up data were available for evaluation. One hundred eighty-eight patients (81%) showed remission initially according to current criteria. So far, 23 of these patients relapsed in the further course, so that on follow-up 165 patients (71%) demonstrated full remission by surgery alone. Most patients in whom remission after surgery failed were treated with somatostatin receptor ligands and/or dopamine agonists as second-line treatment. The main postoperative complications included transient hyponatremia and diabetes insipidus (13/280; 4.6%). CSF leakage only occurred in 2 cases (2/280; 0.7%). No surgery-related death occurred.CONCLUSIONSThe data underline the effectiveness of MTS in acromegaly. Many patients with recurrent disease or incomplete tumor resection can be successfully managed pharmacologically.
Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly
Authors: Cardinal Tyler , Rutkowski Martin J. , Micko Alexander , Shiroishi Mark , Jason Liu Chia-Shang , Wrobel Bozena , Carmichael John , Zada Gabriel 
Published: June 2020

OBJECTIVEAcromegaly is a disease of acral enlargement and elevated serum levels of insulin-like growth factor–1 (IGF-1) and growth hormone (GH), usually caused by a pituitary adenoma. A lack of consensus on factors that reliably predict outcomes in acromegalic patients following endoscopic endonasal transsphenoidal surgery (EETS) warrants additional investigation.METHODSThe authors identified 52 patients with acromegaly who underwent an endoscopic endonasal approach (EEA) for resection of a GH-secreting pituitary adenoma. Preoperative and postoperative tumor and endocrinological characteristics such as tumor size, invasiveness, and GH/IGF-1 levels were evaluated as potential indicators of postoperative hormonal remission. Endocrinological remission was defined as postoperative IGF-1 levels at or below the age- and sex-normalized values.RESULTSThe 52 patients had a mean age of 50.7 ± 13.4 years and a mean follow-up duration of 24.4 ± 19.1 months. Ten patients (19%) had microadenomas and 42 (81%) had macroadenomas. Five patients (9.6%) had giant adenomas. Forty-four tumors (85%) had extrasellar extension, with 40 (77%) exhibiting infrasellar invasion, 18 (35%) extending above the sella, and 7 (13%) invading the cavernous sinuses. Thirty-six patients (69%) underwent gross-total resection (GTR; mean maximal tumor diameter 1.47 cm), and 16 (31%) underwent subtotal resection (STR; mean maximal tumor diameter 2.74 cm). Invasive tumors were significantly larger, and Knosp scores were negatively correlated with GTR. Thirty-eight patients (73%) achieved hormonal remission after EEA resection alone, which increased to 87% with adjunctive medical therapy. Ninety percent of patients with microadenomas and 86% of patients with macroadenomas achieved hormonal remission. Preoperative IGF-1 and postoperative day 1 (POD1) GH levels were inversely correlated with hormonal remission. Postoperative CSF leakage occurred in 2 patients (4%), and none experienced vision loss, death, or injury to internal carotid arteries or cranial nerves.CONCLUSIONSEndoscopic transsphenoidal resection of GH-secreting pituitary adenomas is a safe and highly effective treatment for achieving hormonal remission and tumor control in up to 87% of patients with acromegaly when combined with postoperative medical therapy. Patients with lower preoperative IGF-1 and POD1 GH levels, with less invasive pituitary adenomas, and who undergo GTR are more likely to achieve postoperative biochemical remission.
Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing’s disease? A single-institution experience
Authors: Himes Benjamin T. , Bhargav Adip G. , Brown Desmond A. , Kaufmann Timothy J. , Bancos Irina , Van Gompel Jamie J. 
Published: June 2020

OBJECTIVECushing’s disease arises from functioning adrenocorticotropic hormone (ACTH)–secreting pituitary adenomas. These tumors can be very small and evade detection by MRI. Empty sella syndrome is a phenomenon by which an arachnoid outpouching of CSF into the sella leads to compression of the pituitary, likely due to intracranial hypertension (a common issue in Cushing’s disease), further leading to difficulty in visualizing the pituitary gland that may contribute to difficulty in finding a tumor on MRI, so-called MRI-negative Cushing’s disease. The authors sought to examine the association between empty sella syndrome and MRI-negative Cushing’s disease.METHODSA single-institution database of Cushing’s disease cases from 2000 to 2017 was reviewed, and 197 cases were included in the analysis. One hundred eighty patients had a tissue diagnosis of Cushing’s disease and 17 had remission with surgery, but no definitive tissue diagnosis was obtained. Macroadenomas (tumors > 1 cm) were excluded. The degree of empty sella syndrome was graded on the degree of CSF visualized in the sella on midline sagittal T1-weighted MRI.RESULTSOf the 197 cases identified, 40 (20%) presented with MRI-negative disease, and empty sella syndrome was present in 49 cases (25%). MRI-negative disease was found in 18 (37%) of 49 empty sella cases versus 22 (15%) of 148 cases without empty sella syndrome present. Empty sella syndrome was significantly associated with MRI-negative disease (OR 3.32, 95% CI 1.61–6.74, p = 0.0018). Decreased thickness of the pituitary gland was also associated with MRI-negative disease (mean thickness 5.6 vs 6.8 mm, p = 0.0002).CONCLUSIONSEmpty sella syndrome is associated with an increased rate of MRI-negative Cushing’s disease. Pituitary compression causing a relative reduction in the volume of the pituitary for imaging is a plausible cause for not detecting the tumor mass with MRI.
The Effect of Endorphin Massage towards Decreasing Low Back Pain In Third Trimester Pregnant Women
Authors: Cahyani Ivana Argo , Winarsih Sri , Arfiana Arfiana 
Published: June 2020

Background: Pregnancy becomes a meaningful experience with all the changes both physically and psychologically. One of the changes is discomfort that occurs in the third trimester is lower back pain. Lower back pain can cause disruption of daily physical activity. Endorphin massage can be one of the measures to reduce pain in third trimester pregnant women because it releases endorphins from light massage and positive affirmations from the husband.Methods: This research was conducted in the working area of Pare Public Health Center Temanggung District. The methods used Quasi Experimental with Non-Equivalent Control Group Design. The population of this study were all third-trimester pregnant women with a gestational age of 36 weeks, its about 46 people. The tool used the data collection an observation sheet on the scale of Mankoski pain. Data analysis used Wilcoxon test.Result: The results of the study used Wilcoxon test items, namely p value of endorphin massage group of 0,000 with a value of Z 3.787 and the control group p value of 0.025 with a value of Z 2.235. This showed that both groups were equally influential, but the endorphins group had a stronger influence compared to the control group.Conclusion: Endorphin massage had an effect on reduced lower back pain in the third trimester of pregnant women. Endorphin massage contain mild massage and positive affirmations from husband that stimulated the emergence of endorphin so reduce pain sensation roomates. It was expected that endorphin massage can be applied by pregnant women and husband or families as one method of decreasing low back pain because it helped empower husband / families to improve the welfare of pregnant woman.
Heavy cement materials
Authors: Orlovskyi V. M. 
Published: June 2020

Emphasis is placed on the urgency of the problem of creating cementitious materials and solutions of high density.
The analysis of scientific sources in the field of development and research of modified cement materials with high density is carried out. The application of different types of weighting impurities to well cements is considered. The advantages and disadvantages of the weighting impurities that are used in the modification of well cements are shown. The technological schemes of the most widespread ways of creation of the weighted cement materials are resulted.
The assortment of weighted cement materials manufactured by the Ukrainian industry is analyzed.
It is noted that improving the quality of the delineation of rocks and oil and gas horizons in exploration areas and industrial fields during the cementing of high-pressure layers and zones with abnormally high reservoir pressures is possible by the development possible and application of weighted heat-resistant cements with high technological properties on the basis of ash mixtures, as well as mixtures of standard well Portland cement PTSTI-100 and acidic ash removal of thermal power plants and barite weighing agent.
Weighted and heat-resistant grouting materials with high performance properties with the use of industrial anthropogenic products have been developed and investigated.
The selection of optimal recipes of new weighted cement materials was carried out.
The results of the work have practical application in cementing oil and gas wells in complex mining and geological conditions in exploration areas and industrial hydrocarbon deposits.
OPTIMALISASI RETRIBUSI PASAR DALAM MENINGKATKAN PENDAPATAN ASLI DAERAH KABUPATEN DOMPU PROVINSI NUSA TENGGARA BARAT
Authors: Siregar Kodir 
Published: June 2020

ABSTRACT
Below Market is one of the main economic’s activator of Dompu’s society. Below Market is located at the urban area in Dompu city so it needs to be manage and arrange in order to keep the society’s Economics consist well. Based on that thing, the writer interest to do a research by a tittle “optimization the levies of below Market in order to increase the local revenue of Dompu regency West Nusa Tenggara province. The purpose of this Research was to determine optimization of a levy Market to increase the local revenue, to know the obstruction factor of managing a levy Market and also to know the efforts that the government do to manage a levy Market. A method that the writer use is descriptive qualitative method using inductive approach. The resource of the data that use is secondary and primary data. To collecting the data the writer do the interview and documentation also use the reduction of data analysis. Presentation and Verification. The Research located at BAPPENDA at Dompu Regency. The result of this research showed that optimization of the levies below Market can not give such a high contribution of the local revenue in Dompu Regency, because the result does not maksimum yet. Besides, the realization of the local revenue still can not reach the target, and the less awareness of the levy payer, and also less of the Supervision in the Regency, less of socialization, less of tool and infrastructure. That it is why we hope that government and the society can support in order to decrease the problem and Gide the Solutions to solven the levies of below Market problems.
Keywords: optimization, retribution, local revenue
Bullying Behavior and Social Interaction Ability of School-age Children in Tambangan Public Elementary School 02 Mijen Semarang
Authors: Widyaningsih Tri Sakti , Amalia Rizki , Tamrin Tamrin 
Published: June 2020

Background: Bullying is an aggressive and negative behavior of a person or a group which abuse imbalance power and it is done repeatedly. It aims to hurt the victim by mentally or physically. This action can affect social interaction of children’s life. The number of bullying action showed that 50% occurred in elementary school. Aim: This research aims to analyze the correlation between bullying behavior and social interaction ability in Tambangan Public Elementary School 02 Mijen Semarang. Methods: This study was conducted using cross-sectional approach. Sample size was 122 students, selected using proportional random sampling. The data were collected using questionnaire, then analyzed using Spearman rank test. Results: The results showed that bullying case in elementary school showed in the medium level with the percentage of 54.1% (66 students), medium social interaction with the percentage of 63.1% (77 students). The p-value was 0,000; with the rho of -0.407. Conclusion: There was a correlation between bullying behavior and the social interaction ability of school-age children in Tambangan Public Elementary School 02 Mijen Semarang. Suggestion: Giving stimulus to the school-age children by using assertive communication is expected to prevent bullying action around them.
Keywords: bullying; social interaction; school-age children
Advanced Oxidation Protein Products Contribute to Renal Tubulopathy via Perturbation of Renal Fatty Acids
Authors: Imafuku Tadashi , Watanabe Hiroshi , Satoh Takao , Matsuzaka Takashi , Inazumi Tomoaki , Kato Hiromasa , Tanaka Shoma , Nakamura Yuka , Nakano Takehiro , Tokumaru Kai , Maeda Hitoshi , Mukunoki Ayumi , Takeo Toru , Nakagata Naomi , Tanaka Motoko , Matsushita Kazutaka , Tsuchiya Soken , Sugimoto Yukihiko , Shimano Hitoshi , Fukagawa Masafumi , Maruyama Toru 
Published: June 2020

Background
Renal proximal tubulopathy plays a crucial role in kidney disease, but its molecular mechanism is incompletely understood. Because proximal tubular cells consume a lot of energy during reabsorption, the relationship between fatty acids (FAs) and proximal tubulopathy has been attracting attention. The purpose of this study is to investigate the association between change in renal FA composition and tubulopathy.

Methods
Mice with cisplatin-induced nephrotoxicity were used as a model of AKI and 5/6-nephrectomized mice were used as a model of CKD. Renal FA composition in mice was measured by GC-MS. Human tubular epithelial cells (HK-2 cells) were used for in vitro studies.

Results
In kidneys of AKI mice, increased stearic acid (C18:0) and decreased palmitic acid (C16:0) were observed, accompanied by increased expression of the long-chain FA elongase Elovl6. Similar results were also obtained in CKD mice. We show that C18:0 has higher tubular toxicity than C16:0 via induction of ER stress. Using adenovirus-expressing Elovl6 or siRNA for Elovl6 in HK-2 cells, we demonstrated that increased Elovl6 expression contributes to tubulopathy via increasing C18:0. Elovl6 knockout suppressed the increased serum creatinine levels, renal ER stress, and inflammation that would usually result after 5/6 nephrectomy. Advanced oxidation protein products (AOPPs), specifically an oxidized albumin, was found to induce Elovl6 via the mTORC1/SREBP1 pathway.

Conclusions
AOPPs may contribute to renal tubulopathy via perturbation of renal FAs through induction of Elovl6. The perturbation of renal FAs induced by the AOPPs-Elovl6 system could be a potential target for the treatment of tubulopathy.
Evre IB-III Serviks Kanserinde Definitif ve Adjuvan Radyoterapi Sonuçlarının Karşılaştırmalı Değerlendirilmesi
Authors: KAYMAK ÇERKEŞLİ Zümrüt Arda , ÖZKAN Emine Elif 
Published: June 2020

Amaç: Evre IB-IIA Serviks kanseri tanılı hastaların yarıdan fazlası primer
cerrahi sonrası adjuvan radyoterapiye ihtiyaç duymaktadır. Özellikle büyük tümör
boyutu varlığında tedavide definitif radyoterapi önerilir. Evre III hastalarda ise definitif
kemoradyoterapi standart yaklaşım olarak önerilmekte iken klinik uygulamada
primer modalite olarak cerrahi halen kullanılmaktadır. Bu çalışmada
kliniğimizde FIGO 2018’e göre Evre IB-III serviks kanseri tanısı ile definitif
veya adjuvan radyoterapi uygulanmış hastaların tedavi sonuçlarının
karşılaştırmalı değerlendirilmesi amaçlanmıştır. Materyal ve Metod: 2011-2019 yıllarında kliniğimizde serviks kanseri tanısı ile definitif
radyoterapi (DRT) uygulanan 28 hasta ve adjuvan radyoterapi (ART) uygulanan 20 hasta çalışmaya dahil edildi. DRT
ve ART hasta gruplarının özellikleri Ki-Kare testi ile, genel sağkalım (GS) ve
progresyonsuz sağkalım (PSK) değerlendirmeleri Kaplan-Meier analizi ve log-rank
testi ile, çok değişkenli analizler ise Cox regresyon analizi ile yapıldı. Bulgular: Medyan 39,6 ay(0,5-90,5) takip süresi sonunda 33 hasta hayattaydı. DRT ve
ART gruplarında GS sırasıyla 39,65 ay ve 42,46 ay; PSK sırasıyla 26,10 ay ve
22,93 ay ve 3 yıllık sağkalım oranları sırasıyla %79,6 ve %72,2 idi. İki grup
arasında GS ve PSK açısından istatistiksel olarak anlamlı fark tespit edilmedi
(p=0.936, p=0,756). Çok değişkenli analiz sonuçlarında ECOG durumunun GS
üzerinde, tümör boyutunun ise PSK üzerinde istatistiksel anlamlı etkisi bulundu
(sırasıyla p=0,009, p=0,044). Tedavi modalitesinin ise PSK (p=0,724) veya GS (p=0,908)
üzerinde istatistiksel olarak anlamlı bir etkisi gösterilmedi. Sonuç: Hastaların GS, PSK ve 3 yıllık sağkalım sonuçları literatür ile uyumludur.
Evre IB-III serviks kanserinde definitif radyoterapi ve postoperatif adjuvan
radyoterapi benzer sağkalım sonuçlarına sahiptir. Adjuvan radyoterapiye ihtiyaç
duyacak hastalarda definitif radyoterapi tercih edilmesi düşünülmelidir.
ANALISIS PERNYATAAN STANDAR AKUNTANSI KEUANGAN (PSAK) NOMOR 16 TAHUN 2011 TERHADAP AKUNTANSI AKTIVA TETAP BERWUJUD PADA BADAN PENYELENGGARA JAMINAN SOSIAL (BPJS) KESEHATAN CABANG WATAMPONE
Authors: Nurkurniana Nurkurniana 
Published: June 2020

This research is motivated by the fact that BPJS Health has business activities implementing social security. Each part of this organization takes an important part in presenting services to clients, so that many use fixed assets in their operations. The acquisition of fixed assets requires significant investment, good asset management, and reliable procedural implementation in accordance with the provisions of PSAK Number 16 of 2011 which regulates the accounting treatment of fixed assets. For this reason, it is necessary to know how the accounting treatment for tangible fixed assets at the BPJS Health Branch of Watampone.
This research is a qualitative research through a descriptive approach that will provide clear and accurate information and answers on how the presentation of tangible fixed assets in financial statements and analysis of PSAK No. 16 of 2011 on the accounting treatment of tangible fixed assets at the BPJS Health Branch Watampone.
The location of this study is the Watampone Branch BPJS Health Office. This study lasted for approximately 3 months, namely January - March 2019. Methods of data collection in this study were interviews, observation, document review and literature study.
The results of this study indicate that the Accounting treatment for Tangible Fixed Assets at Branch Health BPJS has not fully complied with the provisions of PSAK Number 16 of 2011.
АВТОНОМІЯ ВЧИТЕЛЯ ІНОЗЕМНОЇ МОВИ: ПРОБЛЕМИ ВИЗНАЧЕННЯ
Authors: Вєтрова Ірина , Вєрьовкіна Олена 
Published: June 2020

Анотація. Стаття присвячена актуальній проблемі визначення автономії вчителя іноземної мови. Автор на основі ретроспективного аналізу зарубіжних праць аналізує й узагальнює наукові погляди на визначення поняття. У статті зазначено поетапний шлях розгляду зарубіжними авторами поняття автономії вчителя. Простежено зміни тлумачення з урахуванням взаємозв’язку автономії учня та автономії вчителя, висвітлено узагальнені погляди на поняття автономії вчителя залежно від характеристик, включених у дефініцію. Автором здійснена спроба розглядати трактування терміну відповідно до фаз становлення вчителя іноземної мови. У роботі означені певні суперечності, які перешкоджають вітчизняному майбутньому вчителеві іноземної мови розвивати автономію упродовж фахової підготовки. Наголошується на важливості розвитку автономії ще впродовж педагогічної підготовки майбутнього вчителя у вищому навчальному закладі, створивши відповідні умови та оновлюючи методичну програму. Відзначено, що підготовці майбутніх вчителів до впровадження навчальної автономії значно сприяла програма з методики навчання англійської мови в рамках спільного проекту Міністерства освіти та науки України й Британської Ради „Шкільний учитель нового покоління”.
Ключові слова: автономія вчителя, автономія учня, професійний розвиток учителя іноземної мови, методична підготовка вчителя.
СУТНІСТЬ ТА ОСОБЛИВОСТІ УКРАЇНСЬКИХ ПЛАТФОРМ МАСОВИХ ВІДКРИТИХ ОНЛАЙН-КУРСІВ (МВОК)
Authors: Петренко Сергій Вікторович 
Published: June 2020

Проаналізовано роль українських масових відкритих онлайн-курсів в організації системи дистанційної освіти в умовах карантину. Схарактеризовано найбільш популярні українські освітні платформи онлайн-освіти: Університет онлайн, Prometheus, EdEra, Освіта-онлайн, EDUGET, ВУМ online, LINGVA SKILLS, Освітній Хаб міста Києва, Brainbasket й ін.
На основі аналізу найбільш популярних вітчизняних платформ масових відкритих онлайн-курсів визначені сутнісні характеристики, особливості МВОК, їх переваги та недоліки.
Особливостями українських освітніх платформ для масових відкритих онлайн-курсів визначено: мультимедійний зміст, що покращує якість засвоєння навчального матеріалу через використання слухових та зорових рецепторів учасників освітнього процесу; контроль доступу до ресурсів, що значно спрощує роботу викладача за рахунок автоматичної реєстрації, формування електронних журналів тощо, що передбачає автоматичну перевірку великої кількості тестових завдань. Такі платформи забезпечують спрощення управління навчанням, можливість адміністративного моніторингу у відповідних документах й т. п.
Переваги МВОК: величезна різноманітність програм і курсів, лояльні витрати на освіту, комфортні умови навчання, гнучкість, використання в курсах різноманітного освітнього контенту, спілкування у відкритих дискусіях на сайті й широкі можливості зосередитися, прояв співробітництва, додаткова освіта, підвищення кваліфікації, відсутність будь-яких обмежень, розширення можливостей здобуття освіти для людей з особливими потребами, орієнтація на інноваційні футуристичні напрями.
Недоліки МВОК: система виключає індивідуальний підхід до студента, проблеми з мотивацією, надлишок та хаотичність навчальної інформації, проблема плагіату, академічної доброчесності, ідентифікації здобувача, якості системи оцінювання, нестача кваліфікованих людських ресурсів, проблема визнання сертифікату успішного закінчення онлайн-курсу університетами і роботодавцями.