bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Benefit with Palliative Local Radiotherapy in Metastatic Nasopharyngeal Carcinoma
Authors: Wen Wen , Yao Ji-Jin , Tang Qing-Nan , Hua Xin , Jin Ya-Nan , Long Zhi-Qing , Xie Shuang-Yan , Huang Han-Ying , Guo Ling , He Zhen-Yu , Zhang Wen-Wen , Mai Hai-Qiang , Lin Huan-Xin 
Published: September 2020

Abstract
Background: The purpose of this study was to evaluate the benefit to be gained from the addition of local radiotherapy to systemic chemotherapy in patients with newly diagnosed metastatic nasopharyngeal carcinoma in endemic areas of Southern China.Methods: The data of patients with metastatic nasopharyngeal carcinoma (n = 649) were retrospectively analyzed: 313 patients received only chemotherapy and 336 received chemotherapy plus radiotherapy. The characteristics of the radiotherapy and chemoradiotherapy groups were compared using the chi-square test or Fisher exact test. Survival was analyzed using the Kaplan–Meier method. A Cox proportional hazard model was used to identify the factors independently associated with survival.Results: Median follow-up was for 36 months. In univariate analysis, radiotherapy was significantly associated with improved survival (median OS 27 vs. 18 months; 5-year OS 36.4% vs. 20.1%; P < 0.001). In multivariate analysis, radiotherapy was an independent predictor of survival (HR, 0.65; CI, 0.53-0.79; P < 0.001). Other independent prognostic factors included number of metastatic organs, smoking, body mass index, hemoglobin, and N stage. In subgroup analysis, chemoradiotherapy was associated with improved survival in both the single-organ metastasis group (5-year OS, 38.5% vs. 25.1%; P < 0.001) and the multiorgan metastases group (5-year OS, 25.0% vs. 9.7%; P = 0.003）.Conclusion: The addition of local radiotherapy to chemotherapy appears to improve survival in patients with metastatic nasopharyngeal carcinoma. Even patients with multiorgan metastases may benefit from radiotherapy.
High capacity manganese layered-perovskite cathode for fluoride ion batteries involving cationic and anionic redox reaction
Authors: Miki Hidenori , Yamamoto Kentaro , Nakaki Hiroyuki , Yoshinari Takahiro , Nakanishi Koji , Nakanishi Shinji , Iba Hideki , Miyawaki Jun , Harada Yoshihisa , Ochi Masayuki , Kuroki Kazuhiko , Uchiyama Tomoki , Watanabe Toshiki , Matsunaga Toshiyuki , Kageyama Hiroshi , Uchimoto Yoshiharu 
Published: September 2020

Abstract
Developing electrochemical high-energy storage systems is of crucial importance towards a green and sustainable energy supply. A promising candidate is fluoride ion batteries (FIBs), which can deliver a higher energy density than is possible with lithium ion batteries1,2. However, conversion-type reactions with metal fluorides causes a poor electrochemical reversibility1,3,4. Recently, layered perovskite oxides such as LaSrMnO4 have been shown to undergo topotactic electrochemical (de)fluorination, but they have low reversible discharge capacities (25 ~ 100 mAh/g) and poor rate capabilities. Here we show that a double-layered perovskite oxyfluoride La1.2Sr1.8Mn2O7–δF2 exhibits topotactic (de)intercalation reaction inside the rock-salt slabs, achieving a large reversible capacity of 535 mAh/cm3 (0 ≤ x ≤ 2 in La1.2Sr1.8Mn2O7–δFx), with excellent cycle stability and rate capability. Surprisingly, despite the close-packed perovskite-based structure, two extra fluoride ions are (de)intercalated beyond x = 2, leading to a reversible capacity of 1168 mAh/cm3 (0 ≤ x ≤ 4). During the further intercalation, oxygen molecules are formed in the perovskite layer, as in Na0.75[ Li0.25Mn0.75 ]O25, which is responsible for the charge compensation (i.e. anion redox)5,6 and the concomitant formation of oxygen vacancies that allow the incorporation of the excess fluoride ions. These results highlight the layered perovskite oxide/oxyfluorides as a new class of active materials for the construction of high-performance FIBs. More generally, the concept of anion-intercalation through O2 formation in the mixed-anion perovskite materials can be used to develop new functionalities.
Assessment Of Knowledge, Attitude And Practice Of Mothers On The Effects Of Sunlight Exposure And Its Associated Factors Among Infants Found In Debre Tabor Town, North Central Ethiopia, 2018
Authors: Feleke Dejen Getaneh , Mesfin Endalkachew , Mekete Gashew 
Published: September 2020

Abstract
Background: Early morning sunlight exposure for infants was a good practice to prevent rickets and alleviate the problem of vitamin D efficiency. Rickets is a major public health problem in many countries of the world. In many rich industrialized countries, the prevalence of rickets in the general population diminished after the introduction of dietary supplementation. But the most cost-effective way of getting vitamin D is simply from sunlight exposure rather than vitamin-D supplementation and advanced treatment. The main objective of this study is to assess the knowledge, attitude and practice of mothers on the effects of sunlight exposure and its associated factors among infants found in Debre Tabor town, North central Ethiopia, 2018. Methods: community-based cross-sectional study had been conducted among 105 mothers with infants in Debre Tabor city, South Gondar Zone, Amhara, Northcentral Ethiopia, 2018 from October 30 -/2018-January 1/2019. To select study participants simple random sampling techniques was employed. Data was entered into Epi info version 7.2.0.1, and exported to SPSS window version 20 for analysis. Binary and Multivariable logistic regression was used to see the association between dependent and independent variables. Odds ratio with 95% confidence interval was computed. P-value < 0.05 was used to declare association. Results: The overall knowledge, practice and attitude of the mothers about sunlight exposure were 61.14%, 59.44%, and 61% respectively, regarding factors associated with knowledge, practice and attitude of mothers about sunlight exposure were highly influenced by good time exposure for sunlight exposure ,mother who exposed their infants to sunlight exposure sometimes were 3.2 times less for acquiring knowledge than mothers who expose their infants who warm daily [AOR: *3.2(1.02-6.4)], mothers who had an occupation of daily laborer were 3.4 times less likely to practice sunlight exposure to their infants governmental workers [AOR: *3.4(0.8 2.8)] and. mothers who do not believe about the good effect of sunlight exposure had 3.3 times negative attitude towards about sunlight exposure than who thinks well [AOR; **3.3(1.5-8.9)] were significantly associated with knowledge ,practice and attitude of mothers about sunlight exposure and the total attitude of the mother’s sunlight exposure was lower than knowledge and practice .Hence; Based on the result the concerned body and health care providers should create awareness about the effect of sunlight exposure through health education.
Anticoagulant in Patients with&nbsp;Pulmonary Embolism and Fatty Liver: A Case Report
Authors: Li Sha-Sha , Lin Wei-Xian , Huang Kun-Yu , Chen Sheng-Yang , Chen Juan , Wang Yu-Ping , Xue Lian-Fang , Liu Hui , Wang Jing-Hao , Zhang Qing 
Published: September 2020

Abstract
AIMS: Patients with liver disease are more prone to thrombosis and bleeding events than healthy people. The decision to use anticoagulation in patients with pulmonary embolism and liver disease requires a cautious evaluation of the risks of bleeding and the beneﬁts of anticoagulation. In order to make a recommendation for patient with fatty liver that developed pulmonary embolism, we reported this case. METHODS: In this paper, we reported a case of a patient with fatty liver that developed pulmonary embolism. The low molecular weight heparin sodium injection and different anticoagulants were evaluated for this patient.RESULTS: After evaluating the efficacy and safety of different anticoagulants in patients with pulmonary embolism and liver dysfunction, rivaroxaban is more suitable for this patient to be treated by sequential therapy. After three weeks of treatment with rivaroxaban, the patient’s blood routine test results were normal, and no side effect was found. CONCLUSIONS: For patients with pulmonary embolism and fatty liver, maybe NOAC is more suitable.
Systemic Inflammation Causes Microglial Dysfunction With a Mixed Ad-like Pathology
Authors: Bathini Praveen , Dupanloup Isabel , Zennaro Elena , Terrabuio Eleonora , Fisher Amrei , Babaliani Edona , Doucey Marie-Agnes , Alberi lavinia 
Published: September 2020

Abstract
BackgroundAlzheimer's disease (AD) is the primary cause of cognitive deficit in elderly humans. Late-onset AD (LOAD) is sporadic, multifactorial, non-Mendelian accounting at present for 95% of the cases in contrast to the genetic form. Risk factors for sporadic AD include Gene: Environment interactions. There is increasing evidence that lifestyle and environmental stress such as infection and chronic inflammation are underlying culprits of neurodegenerative dementia. Dementias that share or mimic pathological processes of AD include cerebrovascular diseases, Lewy body disease, TDP-43 proteinopathy. To date, very few mouse models reproduce the pathophysiological progression of mixed-vascular-AD, while the majority of studies have employed transgenic animals reproducing the familial form. MethodsWe have re-engineered the Polyinosinic:polycytidylic acid (PolyI:C) sterile infection model in wildtype C57Bl6 mice to obtain chronic low-grade systemic inflammation. We have conducted a cross-sectional analysis of aging PolyI:C and Saline control mice (3 months, 6 months, 9 months and 16 months), taking the hippocampus as a reference brain region, based on its vulnerability, and compared the brain aging phenotype to AD progression in humans with mild AD, severe AD and Controls (CTL), parallely in Vascular dementia (VaD) patient specimens.ResultsWe found that PolyI:C mice display both peripheral and central inflammation with a peak at 6 months, associated with memory deficits. The hippocampus is characterized by a pronounced and progressive tauopathy. In PolyI:C brains, microglia undergo aging-dependent morphological rearrangements progressively adopting a phagocytic phenotype. Transcriptomic analysis reveals a profound change in gene expression over the course of aging, with a peak in differential expression at 9 months. We confirm that the proinflammatory marker Lcn2 is one of the genes with the strongest upregulation in PolyI:C mice upon aging. Validation in brains from patients with increasing severity of AD and VaD shows a reproducibility of some gene targets in vascular dementia specimens rather than AD ones, in which only GFAP is strongly increased at the severe stages.ConclusionsThe PolyI:C model of sterile infection demonstrates that peripheral chronic inflammation is sufficient to cause neuropathological processes resembling a mixed-VaD-AD phenotype, with progressive tau hyperphosphorylation, changes in microglia morphology, astrogliosis and gene reprogramming reflecting increased neuroinflammation, vascular remodeling and the loss of neuronal functionality seen to some extent in humans.
Clubfeet and Constriction Band Syndrome - Case Report
Authors: Shabani Bujar , Bytyqi Dafina , Bytyqi Cen 
Published: September 2020

Abstract
Background: Clubfeet and constriction band syndrome is very rare nonidiopathic condition. Treatment is often difficult and the recurrence deformity rate is high. The purpose of this study was to assess the effectiveness of Ponseti method in treatment of congenital constriction band syndrome accompanied clubfoot deformity and lymphedema.Case presentation: We are presenting an interesting case of bilateral clubfeet and congenital circumferential constriction band syndrome in lower limb. Ponseti method of correcting the congenital clubfoot deformity was applied. Constriction band release is accomplished by two stage completely excising the ﬁbrous band and multiple two stage Z-plasties on the right calf.Conclusion: The results of this study indicate that the Ponseti method of gentle, systematic manipulation and weekly cast changes is effective treatment of nonidiopathic clubfoot distal to congenital amniotic constriction band.
Up Regulation of LINC00473 Promotes Cervical Cancer Progression and Predicts Poor Prognosis
Authors: Zhou Xi , Zhao Xia , Wu Zhouyi , Ma Yan , Li Heng 
Published: September 2020

Abstract
Objective Long noncoding RNAs imbalance exert momentous effect in cancer. LINC00473 can accelerate the extensive tumors proceeding. Nevertheless, LINC00473 effects in cervical cancer has less reported. This study focused on estimate the LINC00473 effects in the developing process of cervical cancer and its unknown molecular biological regulation mechanism.Methods qRT-PCR was applied for not only measuring LINC00473 expression but also c-myc, cyclinD1 and β-catenin mRNA expression. Both cell count and transwell methods were utilized for determining cell proliferation and invasion. Western blot was employed to estimate c-myc, cyclinD1 and β-catenin protein expression.Results LINC00473 high-expressed was showed in organizations and cells. The LINC00473 gene knockout muffled the cells development, while LINC00473 overexpressed occured opposite trend. Besides, its knockout dramatically inhibited c-myc, cyclinD1 and β-catenin expression. β-catenin overexpression could rescue restrain effect of LINC00473 low-expression on cells progress. Conclusion The LINC00473 high-expression may promote cervical cells progress through adjusting Wnt/β-catenin pathway.
Risk Factors for Antibiotic Treatment of Pigs Between Birth and Slaughter – A Longitudinal Study
Authors: Burow Elke , Rostalski Anja , Harlizius Jürgen , Simoneit Céline , Tenhagen Bernd-Alois , Käsbohrer Annemarie 
Published: September 2020

Abstract
Background: Recently, we found an association between antibiotic treatment and antibiotic resistance in fecal Escherichia coli from rearing pigs during their life. In this study, our aim was to investigate potential risk factors for antibiotic treatment at different production stages of these pigs.Results: In a longitudinal study, antibiotic use was recorded in commercial pig production chains, starting in 29 breeding herds. Information on housing system and management, management of animals and feeding, animal health and performance was surveyed in the herds. In total 55, 57 and 66 variables were evaluated for the production stages suckling, weaning and fattening. In descriptive and univariable analyses seven to eight variables per production stage were associated with antibiotic use. In multivariable analyses, rodent control carried out by a company was associated with an increased risk of antibiotic treatment (odds ratio (OR), 6.86, confidence limits, CL, 1.12 – 41.83, p = 0.023) at suckling. At weaning, production type (farrow-to-finish vs. movement of pigs to another farm after suckling or weaning; OR 0.15, CL 0.02 – 0.89, p = 0.023) was associated with the risk of antibiotic treatment. During the fattening stage, animals were treated more often when the number of weaned piglets per sow and year increased (additional piglet: OR 2.5, CL 0.6 – 29.6, p = 0.0172).Conclusions: Different risk factors were associated with an increased risk of antibiotic treatment in the individual production stages. Therefore, focus on specific measures, especially at suckling and weaning, when most antibiotics are used, is needed. Further research on key factors driving antibiotic use and the causative pathogens that require treatment is necessary in pig production.
A Comparison of the Analysis of Methods for Feature Extraction and Classification by Wavelet Transform in SSVEP BCIs
Authors: Heidari Hoda , Einalou Zahra , Dadgostar Mehrdad , Hosseinzadeh Hamidreza 
Published: September 2020

Abstract
Most of the studies in the field of Brain-Computer Interface (BCI) based on electroencephalography have a wide range of applications. Extracting Steady State Visual Evoked Potential (SSVEP) is regarded as one of the most useful tools in BCI systems. In this study, different methods such as feature extraction with different spectral methods (Shannon entropy, skewness, kurtosis, mean, variance) (bank of filters, narrow-bank IIR filters, and wavelet transform magnitude), feature selection performed by various methods (decision tree, principle component analysis (PCA), t-test, Wilcoxon, Receiver operating characteristic (ROC)), and classification step applying k nearest neighbor (k-NN), perceptron, support vector machines (SVM), Bayesian, multiple layer perceptron (MLP) were compared from the whole stream of signal processing. Through combining such methods, the effective overview of the study indicated the accuracy of classical methods. In addition, the present study relied on a rather new feature selection described by decision tree and PCA, which is used for the BCI-SSVEP systems. Finally, the obtained accuracies were calculated based on the four recorded frequencies representing four directions including right, left, up, and down.
Updated evaluation of clinicopathologic landscape in histopathologic subtypes of endometrial carcinoma with MMR gene mutation
Authors: Wang Aifen , Hu Weidong , Zhang Qingfu , Ren Hongjiu , Zhang Ziyue , Zhao Zihan , Chen Youguo 
Published: September 2020

Abstract
Objective: This study aimed to identify an optimal screening strategy to detect mismatch repair (MMR) mutation for each histologic subtype of endometrial carcinoma. Material and methods: We performed a comparative analysis of the demographic, clinical, pathologic, and molecular data for 562 patients from The Cancer Genome Atlas database, stratified by tumor histologic subtype.Results: Molecular data, including MLH1, MLH3, PMS1, PMS2, MSH2, MSH3, MSH6, and EPCAM, was available for 562 patients, of which 162 (28.8%) had tumors that were positive for MMR gene mutations. Of these tumors, the penetrate rate of grade 3 endometrioid endometrial carcinoma (84/184, 45.7%) was significantly higher than that of uterine serous carcinoma (35/156, 22.4%) (p < 0.001), grade 2 endometrioid endometrial carcinoma (26/129, 20.2%) (p < 0.001), and grade 1 endometrioid endometrial carcinoma (17/93, 18.3%) (p < 0.001). Of 562 endometrial carcinomas, alterations in MSH2 (n = 55), MSH6 (n = 54), and MSH3 (n = 50) were the most frequent mutations. There were no differences in overall survival and progression-free interval (PFI) between MMR mutation carriers and nonmutation carriers (p >0.05) except that PFI with MMR gene mutation was higher than with MMR proficiency in grade 3 endometrioid endometrial carcinoma (p = 0.014). Conclusions: Grade 3 endometrioid endometrial carcinoma harbored more MMR mutations than grade 1 endometrioid endometrial carcinoma, grade 2 endometrioid endometrial carcinoma, and uterine serous carcinoma. Besides MLH1, MSH2, MSH6, PMS2, and EPCAM mutation, MLH3, MSH3, and PMS1 mutation may be necessary to be screened in patients with newly diagnosed endometrial carcinoma.
Foreign Technologies and Indigenous Innovation Performance: Evidence from Selected African Countries
Authors: Asunka Benjamin Azembila , Ma Zhiqiang , Li Mingxing , Anaba Oswin Aganda , Amowine Nelson 
Published: September 2020

Abstract
This study analyzes the impact of imports and foreign direct investment inflows (FDI) on indigenous innovation in some selected African countries. Panel data of five African countries for the period between 1994 and 2018 is analyzed using trademark applications by residents as proxy for indigenous innovation. A vector error correction model is employed to analyze the short-run causality between variables, and fully modified ordinary least squares to analyze the long-run dynamics among variables. The results show that, on the whole, imported inputs have significant and positive effect on indigenous innovation output, while FDI has negative effects. Policy formulation in the region should encourage imports aimed at creating novel products.
Analysis of schemes of skidding of timber to ensure the resumption of pines on scorched forest
Authors: Ширнин Ю.А. , Ширнин А.Ю. 
Published: September 2020

Подобраны конкурирующие системы машин для обеспечения условий естественного возобновления сосны в пораженных низовым пожаром древостоях. Разработаны рациональные схемы заготовки древесины на обширных территориях. Проведена оценка каждой системы машин. Описаны операции технологических процессов заготовки древесины системами машин, отвечающие требованиям естественного возобновления сосны. Произведено сравнение техно-логических схем и систем машин при проведении рубок в пораженных пожаром древостоях. Разработан математический аппарат, позволяющий оценить экологичность предложенных вариантов планировки площадей, ограниченных квартальными просеками или дорогами. Произведен расчет коэффициента экологичности, который показал процентное соотношение площади волоков к общей площади квартала. Для минимизации площади разрабатываемых территории от воздействия техники предложена технология комбинированной трелевки, которая без прокладки пасечных волоков обеспечит заготовку древесины и сохранение значительной площади для естественного возобновления сосны. В отличие от машинной заготовки деревьев валка и обрезка сучьев на лесосеке бензопилами обеспечивает равномерное распределение обрезанных крон и, следовательно, их жизнеспособных семян по обрабатываемой территории. Для вывозки, заготовленной на пораженной пожаром территории, древесины целесообразно использовать существующие дороги и просеки.
Matched competing machines system to ensure conditions of natural regeneration of pine trees in the affected ground firevostoyah nucleus. Elaborated rational scheme on timbertion of vast territories. The evaluation of each of the machine system. Described radio-operator processes timber machine systems that meet the requirements of natural regeneration of pine. Make-but the comparison of technological schemes and systems of machines during harvesting in the affected fire stands. A mathematical tool for assessing the sustainability of the proposed areas of planning options, restricted quarterly cuttings or roads. Random den environmental factor calculation, which showed the percentage ratio of the co-trails to the total area of the quarter. To minimize the area of the developed area of the impact of technology the technology of the combined logging, which without laying skid trails provide logging and preservation of large ASW-show mercy for natural regeneration of pine. Unlike machine-cooking for felling and limbing saws in the cutting area secu Chivauniform distribution of the circumcision crowns and, consequently, their viable seeds on the treated area. For removal, Zago-tovlennoy on the affected fire areas, wood is advisable to use existing roads and clearings.