bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered hypothalamus functional connectivity with limbic system in fibromyalgia and the modulation effect of intervention
Authors: Kong Jian , Huang Yiting , Liu Jiao , Yu Siyi , Cheng Ming , Chen Helen , Wilson Georgia , Harvey William , Li Wen , Wang Chenchen 
Published: January 2020

Abstract
Background: This study aims to investigate the resting state functional connectivity (rsFC) changes of the hypothalamus in Fibromyalgia patients and the modulation effect of effective treatments. Methods: Fibromyalgia patients and matched healthy controls (HC’s) were recruited. Resting state fMRI data were collected from fibromyalgia patients before and after a 12-week Tai Chi intervention and once from HC’s. Results: Data analysis showed that fibromyalgia patients displayed significantly decreased medial hypothalamus (MH) rsFC with the thalamus and amygdala when compared to HC’s at baseline. After the intervention, fibromyalgia patients showed increased (normalized) MH rsFC in the thalamus and amygdala. Effective connectivity analysis showed disrupted MH and thalamus interaction in fibromyalgia, which nonetheless could be partially restored by Tai Chi. Conclusions: Elucidating the role of the diencephalon and limbic system in the pathophysiology and development of fibromyalgia may facilitate the development of new treatment methods for this prevalent disorder. Trial registration: Trial registration ClinicalTrials.gov Identifier: NCT02407665. Registered 3 April 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02407665
Cholesterol reducer and Thrombolytic therapy in acute ischemic stroke
Authors: Poupore Nicolas , Strat Dan , Mackey Tristan , Brown Katherine , Snell Ashley , Nathaniel Thomas 
Published: January 2020

Abstract
Background Specific clinical risk factors may contribute to worsening or improving neurological functions in an acute ischemic stroke (AIS) patient pre-treated with a cholesterol reducer with a subsequent recombinant tissue plasminogen activator (rtPA) treatment. We investigated clinical risk factors associated with good or poor presenting neurological symptoms in ischemic stroke patients with prior cholesterol reducer use, specifically a statin and rtPA therapy.Methods We retrospectively analyzed baseline clinical and demographic data of 630 patients with AIS taking cholesterol reducers prior to rtPA treatment from January 2010 to June 2016 in a regional stroke center. Progressing (NIHSS ≤ 7) or worsening (NIHSS > 7) scores for neurologic improvement determined measures for treatment outcome. Multivariate logistic regression models identified demographic and clinical factors associated with worsening or progressing neurologic functions.Results Adjusted multivariate analysis showed that in an ischemic stroke population with a combined rtPA and cholesterol reducer medication history, increasing age (OR = 1.032, 95% CI, 1.015-1.048, P < 0.001) and atrial fibrillation (OR = 1.859, 95% CI, 1.098-3.149, P = 0.021) demonstrated a likely association with worsening neurologic functions, while direct admission (OR = 0.411, 95% CI, 0.246-0.686, P = 0.001) and being Caucasian (OR = 0.496, 95% CI, 0.297-0.827, P = 0.007) showed an association with improving or progressing neurologic functions.Conclusion A prior cholesterol reducer, namely a statin, plus rtPA combination may be associated with worsening neurological function for elderly AIS patients with atrial fibrillation, while Caucasians directly admitted to a neurology unit are more likely to show an association with progress or improvements in neurologic functions.
Augmentation Strategies for Clozapine-Resistant Patients with Schizophrenia
Authors: Chiu Yi-Hang , Hsu Chia-Yueh , Lu Mong-Liang , Chen Chun-Hsin 
Published: January 2020

Background:
Clozapine has been used in treatment-resistant patients with schizophrenia. However,
only 40% of patients with treatment-resistant schizophrenia have response to clozapine. Many augmentation
strategies have been proposed to treat those clozapine-resistant patients, but the results are inconclusive. In this
review, we intended to review papers dealing with the augmentation strategies in the treatment of clozapineresistant
patients with schizophrenia.

Method:
We reviewed randomized, double-blind, placebo- or sham-controlled trials (RCT) for clozapine-resistant
patients with schizophrenia in Embase, PsycINFO, Cochrane, and PubMed database from January 1990 to June
2019.

Results:
Antipsychotics, antidepressants, mood stabilizers, brain stimulation, such as electroconvulsive therapy
(ECT) and repetitive transcranial magnetic stimulation, and other strategies, were used as an augmentation in
clozapine-resistant patients with schizophrenia. Except for better evidence in memantine with 2 RCTs and cognitive
behavior therapy in 2 studies to support its effectiveness, we found that all the other effective augmentations,
including sulpiride, ziprasidone, duloxetine, mirtazapine, ECT, sodium benzoate, ginkgo biloba, and minocycline,
had only one RCT with limited sample size.

Conclusion:
In this review, no definite effective augmentation strategy was found for clozapine-resistant patients.
Some potential strategies with beneficial effects on psychopathology need further studies with a larger sample
size to support their efficacy.
AIE Luminogens as Versatile Bioprobes
Authors: Gabr Moustafa T. , Pigge F. Christopher 
Published: January 2020

Background:
Luminogens that feature aggregation induced emission (AIE) are typically
non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid
state.

Discussion:
Unlike conventional fluorophores that exhibit aggregation-caused quenching (ACQ),
utilization of AIE luminogens as bioprobes has featured superior photostability, low background signal,
large Stokes’ shifts, high sensitivity and turn-on luminescent response.

Conclusion:
The versatility of AIE-based luminogens as bioprobes has been demonstrated through
various applications in cell organelle imaging, ion sensing and sensitive detection of biomacromolecules.
Examples of AIE-based luminogens and their applications as luminescent sensors for biosensing
and optical imaging are discussed herein.
A New Generation Nanotherapeutic: pHEMA-Chitosan Nanocomposites in siRNA Delivery
Authors: Eroğlu Erdal , Portakal Hüseyin Saygın , Pamukçu Ayşenur 
Published: January 2020

Background:
Despite great hopes for small interfering RNA (siRNA)-based gene therapies,
restrictions, including the presence of nucleases, reticuloendothelial system and undesired electrostatic
interactions between nucleic acids and the cell membrane, limit the success of these approaches.
In the last few decades, non-viral nucleic acid delivery vectors in nanosize with high biocompatibility,
low toxicity and proton sponge effect have emerged as magic bullets to overcome
these drawbacks.

Objective:
This study aimed to develop poly(2-hydroxyethyl methacrylate) (pHEMA)-chitosan
nanoparticles (PCNp), and to transfect green fluorescent protein (GFP)-silencing siRNA (GsiR) in
vitro.

Methods:
Firstly, PCNp displaying core-shell structure were synthesized and thereafter GsiR was
encapsulated into the core of PCNp. The synthesized PCNp with/without GsiR were characterized
using ultraviolet-visible (UV-vis)-spectroscopy, Fourier-transform infrared (FTIR) spectroscopy,
thermal decomposition, atomic force microscopy (AFM), scanning electron microscopy (SEM), zeta
potential and dynamic light scattering (DLS) measurements. Encapsulation of siRNA into the
pHEMA core coated with chitosan shell was demonstrated using fluorescence and FTIR spectroscopy.

Results:
The surface charges of PCNp and PCNp-GsiR were found to be +39.5 and +40.2, respectively.
In DLS analysis, an insignificant shift in the Z-average diameter of PCNp was observed from
109 nm to 133 nm using the encapsulation of GsiR. In comparison to other studied nanomaterials and
a commercial transfection reagent, our findings suggest a promising GFP-silencing effect of 45%.

Conclusion:
To our knowledge, we have obtained comparable silencing activity with the other studied
equivalents despite using the lowest concentration of siRNA in existing literature.
Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers
Authors: Anlamlert Wirin , Sermsappasuk Pakawadee 
Published: January 2020

Background:
It is still controversial whether pomegranate causes drug interactions.
Pomegranate juice has been shown to inhibit CYP3A in-vitro and animal studies. The coadministration
of pomegranate juice with cyclosporine, a narrow therapeutic drug that is the substrate
of CYP3A, might lead to drug toxicity. The objective of this study is to investigate the effect
of pomegranate juice on the pharmacokinetics of cyclosporine in healthy Thai volunteers.

Methods:
The study design was an open-label, randomized, single dose, crossover study with a 2-
week washout period. Each fasting subject received 2 microemulsion tablets of 100 mg of cyclosporine
with 500 ml of pomegranate juice (test) or 500 ml of water (control). Serial blood samples
were collected up to 24 h after dosing, and blood samples were analyzed for cyclosporine concentrations
by using chemiluminescent microparticle immunoassay. Fourteen healthy volunteers
completed the study.

Results:
The 90% confidence intervals for the test/control ratio using logarithmically transformed
data of area under the concentration-time curve (AUC) from time zero until the last measured concentration
(AUC0-t), AUC from time zero to infinity (AUC0-∞), and maximum concentration (Cmax)
were 91.6-105.6, 92.0-105.2 and 82.3-102.5, respectively. The results were within the accepted
bioequivalence range for narrow therapeutic index drugs (90-111% for AUC and 80-125% for
Cmax). There were no differences in adverse event between the groups.

Conclusion:
Single dose administration of pomegranate juice with cyclosporine did not significantly
affect the oral bioavailability of cyclosporine. However, further work is needed to thoroughly
evaluate the effect of pomegranate on narrow therapeutic drugs.
Aplikasi Hydrogen Rich Water Pada Modifikasi Tepung Kentang Dengan Pengering Gelombang Mikro Sebagai Alternatif Substitusi Gandum
Authors: Budiarti Gita Indah , Sulistiawati Endah 
Published: January 2020

Kentang merupakan umbi tinggi mineral dapat digunakan sebagai bahan alternatif substitusi gandum. Namun, kentang memiliki daya kembang yang rendah dibandingkan gandum. Sehingga dilakukan modifikasi menggunakan hydrogen rich water yang aman untuk makanan dibantu dengan pengering gelombang mikro. Penelitian ini bertujuan untuk mengetahui pengaruh hydrogen rich water terhadap sifat fisikokimia tepung kentang yaitu swelling power, kelarutan, viskositas dan morfologi tepung kentang. Variasi waktu perendaman modifikasi pati dan pH yang digunakan adalah 10, 20, 30, dan 40 menit dan 9, 5. Dari hasil yang diperoleh, perlakuan yang direkomendasikan adalah waktu perendaman 30 menit dan pH 5 dengan nilai swelling power, kelarutan dan viskositas masing-masing 12,51 g/g, 2,28%, dan 1,14 cP. Analisis Scanning Electron Microsopy (SEM) menunjukkan morfologi pati yang telah dimodifikasi kasar dan menyatu. Hasil yang diperoleh lebih tinggi daripada nilai dari tepung terigu. Sehingga kentang dapat dipertimbangkan sebagai bahan alternatif substitusi terigu.
Theological Comments Mentioned in Jamiâ€™ al-Tirmidzi and Its Application in Achieving Acceptance and Understanding Within Muslim Community
Authors: Fouly Nabil 
Published: January 2020

This is a study of the theological comments ofÂ Imam TirmidziÂ and those of which he mentioned in his book â€œal-Jamiâ€™ al-Kabirâ€.Â These comments provide us a picture of how the early generations ofÂ IslamÂ dealt with the issues related to Creed andÂ Aqeda,Furthermore the issue of scarcity of views and comments associated to the earlygenerations ofÂ IslamÂ in dealing the issues of Creed andÂ AqedaÂ is also dealt with in this study.Â Most of the comments ofÂ at-TirmidziÂ in the study are mentioned as exact quotations and then they are classified according to the topics they are related to, and after classification analysis of the content along with the methodology and inclination ofthe holder of the opinion regarding these issues ofÂ AqedaÂ is studied. The study shows that the issue which overwhelmed and kept the early generation of Islam occupied was the issue ofÂ amal(Actions) related to those issues of creed or in other words theywere more interested in the actions which has to exist as a result of thatÂ aqedahÂ hence those whose thoughts and emotions are attached to these early generations ofÂ IslamÂ have to follow them in their pursuit of actions more than any other thing. Moreover regarding the conception of anthropomorphistic attributes the study yields that the more accurate and sound opinion associated to the early generations in this regard in the opinion ofÂ Tafwedhi.e to depute the knowledge of its meaning to Godalone and that on extremely rare occasions they use to incline towards theirÂ taweeli.e metaphorical interpretation. And this last issue in particular must and should be discussed within scholarly circles only and the general public should refrain from indulging themselves in such technical issues.Â
The Role of Sufism in Spreading Islam and Fighting Atonement
Authors: Ali Isa Abdullah 
Published: January 2020

This paper delivered the need for Islamic thought to confront the Takfiri thought, through the return of Sufi thought. Sufism does not have fatwa to kill others, SufismÂ talks about tolerance, the love of the Prophet, and the non-compulsion of others tojoin either Islam or the way the murid belongs to. Sufism represents the spiritual andÂ faithful state of Islam, the core of Islam.Â This paper find out the role of Sufism in the spread of Islam; in the past, and the contemporary in the fight against atonement. The aim of this paper is to describe the culture of Sufism, this paper studies the intellectual of Sufism, Sufim cultural, and politics as well. This paper studied about three main axis of Sufism; the culture and history of Sufism, the role of Sufism in spreading Islam, and the role of Sufism in addressing the Takfiri thought. Based on this study, the Islamic institution and government should adopt and adapt the Sufi thought, and to address the Takfiri culture, to prevent Muslim from joining the Takfiri groups
Cultural Symbol dan Politik Identitas dalam Pembangunan Kota Sampit
Authors: Ma'rufah Thau'am 
Published: January 2020

This study aims to trace the cultural symbols and identity politics that occur in the city of Sampit. This is based on several important things that happened in Sampit. Sampit is a heterogeneous and multicultural city and at the same time there were riots between the Dayak and Madura tribes around 2000, which resulted in the emptying and rejection of Madurese residents. At least in the past two decades, Sampit has turned into a city that displays an identity as a Muslim city with the emergence of urban icons built by local elite leaders. It is interesting to track what exactly is behind the elite officials in the city of Sampit in building these identity symbols and how political symbol culture plays a role in the development of the city of Sampit. The analytical tool used in this study is functional sociology where the emphasis of this study is on actors who provide change in society. The results of this study indicate that several valuesÂ obsess over Cultural Symbol actions in Sampit, including;Â First, religious values, one of which orientates the cultural symbol policy is that the Sampit community is moved to worship their Lord and minimize criminal acts that used to occur frequently, such as wild speeding, theft and obscene acts.Â Secondly, art values, symbols used such as the dome and calligraphy ofÂ Asmaul Husnaand calligraphy of Allah and Muhammad's writings are expressions of the architectural art valuesÂ possessed by the Sampit regent which used to beautify the city of Sampit.Â Third, Political Interest, every policy carried out by an elite certainly cannot be separated from political interests, the Sampit regent is no exception, which in this case is to perpetuate his power, bearing in mind that the regent is in power for two periods untill 2020
مفهوم دار الحرب في فقه الإسلامي
Authors: Ahmad Abdullah Abu Bakr 
Published: January 2020

This research aims to give the reader a comprehensive view of the concept of Daral-Harbaccording tosharia Islamic Law. The first and foremost is to explain some of its terminologies, it defines the concept of Dar al-Harb (state of war) literally and technically. Then it combines the concept of the House of the Covenant and the raising of forms from the terms Dar al-Harb(state of war) and Dar al-Islam(Islamic state). It concludes by mentioning what the house becomes as the house of Islam and vice versa. The research concludedthat - The House of Islam does not turn in any case from the whole situation to the house of Kufr unless proven and verify that most of the inhabitants are infidels or apostates, and showed the provisions of the infidels and went from the country and all the features and rituals of the Islamic religion as occurred in Andalus.At the end,the conclusiondrawn from variant views of the scholarsand the main findings and recommendations have been given
Muslimah Beauty: Negotiating Veiling, Piety and Commodity in the New Indonesian Public Sphere
Authors: Sunesti Yuyun 
Published: January 2020

This paper explores the veiling issues and the negotiation of piety among women in Komunitas Muslimah Beauty of Detik Forum. This paper examines to what extent this online community discusses hijab as fashion and piety? what the basis of the arguments for negotiating them? and how is piety constructed through commodity by women in that forum? The answers to this question are important to understand because they examine the assumption considering the lack of connection between piety and veiling when both are more materialized in such of commodity fetishism. To do this, I analyze the online discussion within the Komunitas Muslimah Beautiful in detik.com website. The findings of the paper inform both sociological understanding of the rise democracy in terms of the public sphere as well as the negotiation of women in their effort to connect veiling and piety within their online discussion.Â Keywords: agency, piety, commodity, public sphere, beauty
Perseteruan Memori Kolektif: Kontestasi Islam dan Politik di Tasikmalaya Pasca-Orde Baru
Authors: Mudzakkir Amin 
Published: January 2020

Tulisan ini bertujuan memahami Islam politik pasca-Orde Baru, dengan mengambil kasus di Tasikmalaya, dari perspektif sejarah dan reaktualisasinya. Maurice Halbwachs dan Pierre Nora menyebut hal terakhir itu sebagai memori, yang dianggap antitesis sejarah. Dalam praktiknya, batas antara sejarah dan memori memang kabur atau dikaburkan. Untuk analisis di tulisan ini, dua hal tersebut diposisikan berbeda. Fokus tulisan adalah memahami sejauh mana demokrasi bekerja dalam nilai-nilai kultural setempat yang mungkin bertentangan dengan pandangan HAM liberal. Kasus Tasikmalaya ini menarik untuk diletakkan dalam konteks â€œkomunitarianisme demokratisâ€ dan secara lebih luas dapat digunakan untuk melihat toleransi di Indonesia dengan kacamata kerjasama antara prinsip universal HAM dan interpretasi-interpretasi agama yang berpijak pada pengalaman komunal.Â Kata kunci: Tasikmalaya, Islam politik, Orde Baru, Memori Kolektif
Design of a Human Knee Reeducation Mechanism
Authors: Brahmia Allaoua , Kelaiaia Ridha 
Published: January 2020

Abstract
To establish an exercise in open muscular chain rehabilitation (OMC), it is necessary to choose the type of kinematic chain of the mechanical / biomechanical system that constitutes the lower limbs in interaction with the robotic device. Indeed, it’s accepted in biomechanics that a rehabilitation exercise in OMC of the lower limb is performed with a fixed hip and a free foot. Based on these findings, a kinematic structure of a new machine, named Reeduc-Knee, is proposed, and a mechanical design is carried out. The contribution of this work is not limited to the mechanical design of the Reeduc-Knee system. Indeed, to define the minimum parameterizing defining the configuration of the device relative to an absolute reference, a geometric and kinematic study is presented.
A Four-Node Tetrahedral Finite Element Based on Space Fiber Rotation Concept
Authors: Meftah Kamel , Sedira Lakhdar 
Published: January 2020

Abstract
The paper presents a four-node tetrahedral solid finite element SFR4 with rotational degrees of freedom (DOFs) based on the Space Fiber Rotation (SFR) concept for modeling three-dimensional solid structures. This SFR concept is based on the idea that a 3D virtual fiber, after a spatial rotation, introduces an enhancement of the strain field tensor approximation. Full numerical integration is used to evaluate the element stiffness matrix. To demonstrate the efficiency and accuracy of the developed four-node tetrahedron solid element and to compare its performance with the classical four-node tetrahedral element, extensive numerical studies are presented.
Femina oeconomica. Fighting against Landflucht in the Program of Agrarian Women’s Movement in Prussia before the Outbreak of World War I
Authors: Szudarek Agnieszka 
Published: January 2020

Abstract
In February 1914, the Agricultural Associations of Housewives, operating in the Eastern provinces of Prussia since the 1890s, were subordinated to organisations responsible for the development of agriculture in Prussia, which were dominated by conservatives and noble landowners. This came about on the initiative of some influential agrarians, who, in this way, wanted to strengthen their influence in rural areas, as well as to include the women’s agrarian movement in combating the outflow of labour from agriculture. The women’s organizations, having been politicized in this way and adopted by agrarian leaders after 1908, were to implement a new strategy for preventing the migration of rural population to cities. This is as a resulted of the partial support for Heinrich Sohnrey’s programme and his concept of improving the quality of life in rural areas. Elisabet Boehm, the founder of the associations, from the very beginning of their existence, sought to cooperate with agricultural organizations. She believed that this would be the only way for members to gain access to the expertise for implementing the main point of the association’s agenda, i.e. the professionalization of women’s work in rural areas. The article focuses on explaining the circumstances that led to the interest of the agrarians in the women’s agrarian movement and its inclusion in the reform programme for rural prosperity launched just before the war and showing that the cooperation was primarily aimed at using the associations to strengthen their influence in rural areas.
ANALIZA I OBRADA TEKSTA POMOĆU RAZLIČITIH MODELA TEMA
Authors: Hrnjaković Olivera 
Published: January 2020

Ovaj rad opisuje trenutne mogućnosti i ograničenja postojećih algoritama za izdvajanju tema iz teksta. Dat je teorijski prikaz popularnih modela tema uz sve neophodne korake analize i obrade teksta koji se izvršavaju pre slanja podataka na ulaz modela. Praktičan deo rada je izdvajanje tema iz pitanja sa sajta Stack overflow. Upoređeni su LSA, PLSA i LDA pristup, a evaluacija modela je izvršena određivanjem koherent­nosti tema odgovarajućim merama, imenovanjem tema i analizom njihove vizuelizacije u prostoru. Kako modeli tema unapred zahtevaju navođenje broja tema koje će biti izdvojene iz teksta, deo rada posećen je optimizaciji hiperparametara. Izabrani model za modelovanje tema jeste LDA sa 6 tema. Da bi se dobila numerička procena performansi modela 30 pitanja je ručno označeno imenima dobijenih tema i simuliran je klasifikacioni model. Ova pitanja su korišćena kao test skup podataka u kreiranom LDA klasifikacionom modelu. Postignuta je uspešnost od 77% tačnosti.