bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discussion of ‘Estimating time-varying causal excursion effects in mobile health with binary outcomes’
Authors: Kim S , Cho H , Bang D , De Marchi D , El-Zaatari H , Shah K S , Valancius M , Zikry T M , Kosorok M R 
Published: October 2020

SummaryIn this discussion, we examine the contributions of Qian et al. (2021) and potential applications of the newly developed estimator for the causal excursion effect in binary outcome data. Specifically, we consider extension of their method to count outcomes and observational data, propose an alternative use of their method for analysing excursion effect trajectories and discuss ways of improving estimator efficiency.
Do Contact Precautions Reduce the Incidence of Intensive Care Unit–Acquired Pseudomonas aeruginosa Infections? The DPCPYO (Detection and Contact Precautions for Patients With P. aeruginosa) Cluster-Randomized Crossover Trial
Authors: Slekovec Céline , Robert Jérôme , Berthelot Philippe , van der Mee-Marquet Nathalie , Rogues Anne-Marie , Derouin Véronique , Cholley Pascal , Bertrand Xavier , Gbaguidi-Haore Houssein ,   DPCPYO Trial Group, Capellier Gilles , Samain Emmanuel , Boyer Alexandre , Dubois Véronique , Gruson Didier , Dumenil Anne-Sylvie , Guillet-Caruba Christelle , Jacobs Fréderic , Arbelot Charlotte , Benmansour Hanaa , Drieux-Rouzet Laurence , Monsel Antoine , Carricajo Anne , Diconne Eric , Grattard Florence , Maillard Nicolas , Morel Jérôme , Pozzetto Bruno , Dos Santos Sandra , Ferrandière Martine , Quentin Roland , Tellier Anne-Charlotte 
Published: October 2020

Abstract

Background
The issue of contact precautions as contributory factors for reducing Pseudomonas aeruginosa (Pa) infections in intensive care units (ICUs) remains questioned. We evaluated the impact of the addition of contact precautions to standard precautions for Pa-positive patients on incidence of ICU-acquired Pa infections.

Methods
In this multicenter, cluster-randomized crossover trial, 10 French ICUs were randomly assigned (1:1) to sequence 0–1 (6-month control period [CP]/3-month washout period/6-month intervention period [IP]) or sequence 1–0 (6-month IP/3-month washout period/6-month CP). A surveillance screening program for Pa was implemented. Competing-risks regression models were built with death and discharge without the occurrence of ICU-acquired Pa infection (the primary outcome) as competing events. Models were adjusted for within-ICU correlation and patient- and ICU-level covariates. The Simpson diversity index (SDI) and transmission index (TI) of Pa isolates were derived from pulsed-field gel electrophoresis typing.

Results
Within recruited ICUs, the cumulative incidence and incidence rate of ICU-acquired Pa infections were 3.38% (55/1625) versus 3.44% (57/1658) and 3.31 versus 3.52 per 1000 patient-days at risk during the CP and IP, respectively. Multivariable models indicated that the intervention did not significantly change the cumulative incidence (subdistribution hazard ratio, .91; 95% confidence interval [CI], .49–1.67; P = .76) or rate (cause-specific hazard ratio, 1.36; 95% CI, .71–2.63; P = .36) of the primary outcome. SDI and TI did not significantly differ between CP and IP.

Conclusions
The addition of contact precautions to standard precautions for Pa-positive patients with a surveillance screening program does not significantly reduce ICU-acquired Pa infections in non-outbreak situations.
Clinical Trials Registration. ISRCTN92710225.
From Limits to Ecocentric Rights and Responsibility: Communication, Globalization, and the Politics of Environmental Transition
Authors: Murphy Patrick D , Castro-Sotomayor José 
Published: October 2020

AbstractThis article provides a comparative map of the outstanding discursive features and shared underpinnings of the Limits and Transition discourses (TDs) by examining how they have been communicated to reshape the public sphere. Though both are deeply implicated in globalization, the formation of these environmental discourses responds to distinct sets of social agents and interests and to different but complementary ontological and epistemological grounds. In the Global North, the Limits discourse challenged the assumption of unmitigated growth yet has remained anthropocentric. Environmental TDs associated with the Global South present more contestatory positions on the notion of growth by problematizing human-centeredness and embracing a radical ethics of care. Limits and TDs represent paradigmatic shifts in the history of environmentalism. Accordingly, communication scholars should consider the lessons that can be taken from these discursive fields to foster regenerative ecocultural identities and animate progressive thinking on environmental governance and its communication practices that serve both human and non-human wellbeing.
An update of KAIKObase, the silkworm genome database
Authors: Yang Ching-chia , Yokoi Kakeru , Yamamoto Kimiko , Jouraku Akiya 
Published: October 2020

Abstract
KAIKObase was established in 2009 as the genome database of the domesticated silkworm Bombyx mori. It provides several gene sets and genetic maps as well as genome annotation obtained from the sequencing project of the International Silkworm Genome Consortium in 2008. KAIKObase has been used widely for silkworm and insect studies even though there are some erroneous predicted genes due to misassembly and gaps in the genome. In 2019, we released a new silkworm genome assembly, showing improvements in gap closure and covering more and longer gene models. Therefore, there is a need to include new genome and new gene models to KAIKObase. In this article, we present the updated contents of KAIKObase and the methods to generate, integrate and analyze the data sets.
Database URL: https://kaikobase.dna.affrc.go.jp
Landscape Composition and Fungicide Exposure Influence Host–Pathogen Dynamics in a Solitary Bee
Authors: Krichilsky Erin , Centrella Mary , Eitzer Brian , Danforth Bryan , Poveda Katja , Grab Heather 
Published: October 2020

AbstractBoth ecosystem function and agricultural productivity depend on services provided by bees; these services are at risk from bee declines which have been linked to land use change, pesticide exposure, and pathogens. Although these stressors often co-occur in agroecosystems, a majority of pollinator health studies have focused on these factors in isolation, therefore limiting our ability to make informed policy and management decisions. Here, we investigate the combined impact of altered landscape composition and fungicide exposure on the prevalence of chalkbrood disease, caused by fungi in the genus Ascosphaera Olive and Spiltoir 1955 (Ascosphaeraceae: Onygenales), in the introduced solitary bee, Osmia cornifrons (Radoszkowski 1887) (Megachilidae: Hymenoptera). We used both field studies and laboratory assays to evaluate the potential for interactions between altered landscape composition, fungicide exposure, and Ascosphaera on O. cornifrons mortality. Chalkbrood incidence in larval O. cornifrons decreased with high open natural habitat cover, whereas Ascosphaera prevalence in adults decreased with high urban habitat cover. Conversely, high fungicide concentration and high forest cover increased chalkbrood incidence in larval O. cornifrons and decreased Ascosphaera incidence in adults. Our laboratory assay revealed an additive effect of fungicides and fungal pathogen exposure on the mortality of a common solitary bee. Additionally, we utilized phylogenetic methods and identified four species of Ascosphaera with O. cornifrons, both confirming previous reports and shedding light on new associates. Our findings highlight the impact of fungicides on bee health and underscore the importance of studying interactions among factors associated with bee decline.
Repeated transcatheter aortic valve implantation for the treatment of a degenerated transcatheter aortic valve implantation valve (valve-in-valve technique): a case report
Authors: Voudris Vassileios , Iakovou Ioannis , Kosmas Ilias , Sbarouni Eftychia 
Published: October 2020

Abstract

Background
Valve-in-valve transcatheter aortic valve implantation (TAVI) has emerged as a competent alternative for the treatment of degenerated bioprosthetic valves after surgical aortic valve replacement, or during TAVI procedure as a bailout option. Herein, we report a rare case of a self-expandable Medtronic Evolut R valve into a failing Medtronic CoreValve, with the use of modern pre-TAVI imaging screening, suggesting the proper procedural design steps for so complicated implantations.

Case summary
A frail 78-year-old woman with a degenerated Medtronic Core Valve 26 mm bioprosthesis, implanted in 2011 due to severe aortic stenosis, was referred to our hospital due to worsening dyspnoea New York Heart Association III. The screening echocardiography documented severe aortic stenosis, while the classical risk scores were in favour of repeated TAVI (EuroSCORE II 5.67%). Computed tomography measurements and three-dimensional (3D) printing model were of great help for the proper valve selection (Medtronic Evolut R 26 mm), while the use of cerebral protection device (Claret Sentinel) was considered as a necessary part of the procedure. The simultaneous use of fluoroscopy and transoesophageal echocardiogram led to optimal haemodynamic result, confirmed by the discharge echocardiogram, with a significant clinical improvement during the first month follow-up.

Discussion
The main periprocedural concerns remain valve malpositioning, coronary artery obstruction, and high remaining transvalvular gradients. The multimodality pre-TAVI imaging screening may be helpful for precise procedural design. Despite the limited use of 3D models, it is necessary to adopt such tissue-mimicking phantoms to increase the possibility of optimal procedural result.
‘There But For The Grace of God Go I’: Middle-Class Catholic Responses to Ireland’s Great Famine
Authors: Delaney Enda 
Published: October 2020

Abstract
Over the course of the nineteenth century, the Irish Catholic middle class became more powerful in both political and economic terms. It was this group that became the backbone of Irish nationalism as it emerged in the 1870s and 1880s. But how did the Catholic middle classes respond to what was the greatest disaster in Irish history, Ireland’s Great Famine of the 1840s? This article offers an account, based on a wide range of evidence, of the responses to the events of the Famine years, focusing especially on the role of the rural middle classes and the Catholic clergy, two of the most powerful elements within Irish political and social life. The overall argument is that, while it suited later nationalists to underline the universal nature of the catastrophe, suffering during the Great Irish Famine was concentrated in the ranks of the Catholic rural underclass, which was decimated by death and emigration.
Frailty Changes Predict Mortality in 4 Longitudinal Studies of Aging
Authors: Stolz Erwin , Hoogendijk Emiel O , Mayerl Hannes , Freidl Wolfgang 
Published: October 2020

Abstract

Background
Baseline frailty index (FI) values have been shown to predict mortality among older adults, but little is known about the effects of changes in FI on mortality.

Methods
In a coordinated approach, we analyzed data from 4 population-based cohorts: the Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), the English Longitudinal Survey of Ageing (ELSA), and the Longitudinal Aging Study Amsterdam (LASA), comprising a total of 24 961 respondents (65+), 95 897 observations, up to 9 repeated FI assessments, and up to 23 years of mortality follow-up. The effect of time-varying FI on mortality was modeled with joint regression models for longitudinal and time-to-event data.

Results
Differences (of 0.01) in current FI levels (hazard ratio [HR] = 1.04, 95% credible interval [CI] = 1.03–1.05) and baseline FI levels (HR = 1.03, 95% CI = 1.03–1.05) were consistently associated with mortality across studies. Importantly, individuals with steeper FI growth also had a higher mortality risk: An increase in annual FI growth by 0.01 was associated with an increased mortality risk of HR = 1.56 (95% CI = 1.49–1.63) in HRS, HR = 1.24 (95% CI = 1.13–1.35) in SHARE, HR = 1.40 (95% CI = 1.25–1.52) in ELSA, and HR = 1.71 (95% CI = 1.46–2.01) in LASA.

Conclusions
FI changes predicted mortality independently of baseline FI differences. Repeated assessment of frailty and individual’s frailty trajectory could provide a means to anticipate further health deterioration and mortality and could thus support clinical decision making.
Lessons in Resilience: Initial Coping Among Older Adults During the COVID-19 Pandemic
Authors: Fuller Heather R , Huseth-Zosel Andrea 
Published: October 2020

AbstractBackground and ObjectivesIn addition to increased physical health risks, older adults may also experience risks to their mental health and social well-being due to coronavirus disease 2019 (COVID-19). Yet, older adults may be uniquely able to cope given their life experiences and coping mechanisms. This study explores older adults’ coping experiences and strategies during the initial weeks of the COVID-19 pandemic.Research Design and MethodsA Midwestern sample of 76 older adults aged 70–97 years completed a phone interview about their experiences with social distancing due to COVID-19. Interviews were conducted during the early weeks of regional social distancing (March 28–April 20, 2020). Participants rated their level of perceived coping and responded to open-ended questions about their daily life and coping.ResultsMean perceived coping level (on a scale from 1 to 10) was 7.9, with 87% of participants rating their coping positively. Primary themes that emerged included (a) staying busy, (b) seeking social support, and (c) having a positive mindset. These emotion-focused coping strategies appeared adaptive in the early weeks of the pandemic for most older adults.Discussion and ImplicationsContrary to predominant messaging about the vulnerability of older adults, these findings highlight the resilient nature of older adults in terms of their psychological coping and adaptability during COVID-19. Future research should build upon these findings to better understand and promote late-life coping during crises. Practitioners should seek to support older adults’ engagement in such proactive coping, and social policies should be developed to acknowledge the variable needs of older adults.
On the distribution of Verwey transition temperatures in natural magnetites
Authors: Jackson Mike J , Moskowitz Bruce 
Published: October 2020

SUMMARYThe Verwey transition in magnetite is a crystallographic phase transition occurring in the temperature range 80–125 K and depends on stoichiometry and cation substitution, which may in turn serve as an indicator of the conditions under which magnetite was formed or altered in nature. We have analysed the distribution of Verwey transition temperatures (TV) in a large set of samples (N = 1110) from a wide variety of rocks, sediments, and other natural and synthetic materials containing magnetite, mined from the database of the Institute for Rock Magnetism and from published studies. The analysis is restricted to measurements of remanence while warming through the transition from which TV was determined by the derivative method. Our analysis showed that the TV distribution exhibited a generally bimodal distribution of Verwey transition temperatures, both for the entire data set and for almost all of the lithological subsets. There is a sharp peak for values in the range 118–120 K, and a broad, relatively flat or polymodal distribution from about 98 to 118 K. The upper end of the distribution was sharp, with only a few values exceeding 124 K, and the tail on the lower end extended down to about 80 K. Virtually all of the sample types exhibited polymodal distributions, almost always with one peak near 120 K, and with one or more additional peaks at lower temperatures. Biogenic magnetites produced by magnetotactic bacteria had the lowest modal value of TV (100 K). Loesses (103.5 K) and igneous extrusives (102.5 K) also had low modal transition temperatures and distributions with dominant low-TV peaks. Lithological groups with the highest modal transition temperatures were modern soils (119.5 K), silicate minerals with exsolved magnetite (119 K) and sedimentary rocks (119 K). Numerical experiments confirmed that the derivative method for the determination of TV was reasonably robust and that the observed distributions cannot be explained as an artefact related to the determination of TV from individual thermomagnetic runs but rather is a general characteristic of natural magnetites. The results provide context for studies that interpret TV in particular samples in terms of natural processes or conditions during formation or alteration of magnetite.
A new transdisciplinary research model to investigate and improve the health of the public
Authors: Pineo Helen , Turnbull Eleanor R , Davies Michael , Rowson Mike , Hayward Andrew C , Hart Graham , Johnson Anne M , Aldridge Robert W 
Published: October 2020

Summary
Transdisciplinary research approaches are being applied to today’s complex health problems, including the climate crisis and widening inequalities. Diverse forms of disciplinary and experiential knowledge are required to understand these challenges and develop workable solutions. We aimed to create an updated model reflective of the strengths and challenges of current transdisciplinary health research that can be a guide for future studies. We searched Medline using terms related to transdisciplinary, health and research. We coded data deductively and inductively using thematic analysis to develop a preliminary model of transdisciplinary research. The model was tested and improved through: (i) a workshop with 27 participants at an international conference in Xiamen, China and (ii) online questionnaire feedback from included study authors. Our revised model recommends the following approach: (i) co-learning, an ongoing phase that recognizes the distributed nature of knowledge generation and learning across partners; (ii) (pre-)development, activities that occur before and during project initiation to establish a shared mission and ways of working; (iii) reflection and refinement to evaluate and improve processes and results, responding to emergent information and priorities as an ongoing phase; (iv) conceptualization to develop goals and the study approach by combining diverse knowledge; (v) investigation to conduct the research; (vi) implementation to use new knowledge to solve societal problems. The model includes linear and cyclical processes that may cycle back to project development. Our new model will support transdisciplinary research teams and their partners by detailing the necessary ingredients to conduct such research and achieve health impact.
‘It’s basically everywhere’: young adults’ perceptions of gambling advertising in the UK
Authors: Torrance Jamie , Roderique-Davies Gareth , Thomas Samantha L , Davies Nyle , John Bev 
Published: October 2020

Summary
In comparison to jurisdictions, such as Australia, limited research has focused upon the perceptions and reported effects of gambling advertising within the unique gambling environment of the UK. An online qualitative survey was conducted with 62 young adult gamblers in the UK. The survey investigated the place, meaning and influence of gambling advertising within the lives of the participants. Demographic data were analyzed using descriptive statistics, with qualitative data interpreted using inductive thematic analysis techniques. Three themes were identified. Firstly, young adults were highly cognizant of UK gambling advertising strategies. Second, young adults were able to describe the influence of gambling advertising including its normalizing effect and proliferation of misleading messages. Finally, young adults perceived that current harm minimization strategies, including responsible gambling messages, were ineffective. Many were supportive of increased regulation of gambling advertising. The findings indicate that young adults are aware of the potential risks associated with gambling advertising and are supportive of regulatory reform. It is important that the views and perspectives of young adults are fully considered by regulators and policy makers in the UK, particularly as they are a potential target demographic for the industry.
Iodine and fertility: do we know enough?
Authors: Mathews Divya M , Johnson Neil P , Sim Robert G , O'Sullivan Susannah , Peart Jane M , Hofman Paul L 
Published: October 2020

Abstract
Iodine is a vital micronutrient and its importance in thyroid function is well established. However, abnormalities in iodine intake may also have other effects. In particular, iodine is taken up avidly by the ovary and endometrium. Iodine deficiency is associated with reduced fertility. The use of high iodine concentration contrast media has recently been shown to improve conception rates in couples with unexplained infertility (UI). We hypothesize that this improvement could be related to the iodine excess and mechanisms independent of its action on thyroid. In this article, the metabolism of iodine and its potential role in fertility will be discussed, including the impact of both iodine deficiency and excess states and the importance of iodine in normal fetal development. This will include insights from animal studies on the effect of iodine in the uterine and ovarian structural environment, hormonal milieu and immunological factors affecting implantation. We speculate that iodine may well have a role as a potential therapy for UI.
Comparison of approaches for incorporating depredation on fisheries catches into Ecopath
Authors: Clavareau Lyndsay , Marzloff Martin P , Trenkel Verena M , Bulman Catherine M , Gourguet Sophie , Le Gallic Bertrand , Hernvann Pierre-Yves , Péron Clara , Gasco Nicolas , Faure Johanna , Tixier Paul 
Published: October 2020

AbstractEcosystem-based approaches are increasingly used in fisheries management to account for the direct trophic impacts of fish population harvesting. However, fisheries can also indirectly alter ecosystem structure and functioning, for instance via the provision of new feeding opportunities to marine predators. For instance, marine depredation, where predators feed on fishery catches on fishing gear, is a behaviour developed by many marine species globally. This behaviour can modify both the ecological role of predators and fisheries performance. Yet, these ecosystem-wide effects of depredation are rarely considered holistically. In this study, we explored different ways of incorporating depredation into an Ecopath trophic model. We assessed, through a subantarctic case study, how three alternative model structures can account for depredation effects on fishery catches, predator and non-commercial prey populations, as well as target fish stocks. While none adequately addresses all facets of depredation, the alternative models can to some extent capture how depredation can lead to increased fishing pressure on stocks. As structural specificities of Ecopath prevented us from representing other depredation effects such as provisioning effects for predator populations, we conclude this study with a set of guidance to effectively capture the complex effects of depredation in marine ecosystems and fisheries models.