bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer treatment decisions for people living with dementia: experiences of family carers
Authors: Hynes Catherine , Mitchell Caroline , Wyld Lynda 
Published: June 2020

BackgroundDementia and cancer are both diseases associated with older age. The National Cancer Data Audit in England found that 4.4% of people diagnosed with cancer also had cognitive impairment. Decisions about cancer treatment can be very complex when someone already has dementia. Often someone’s closest relative may be asked to make decisions on their behalf. Little is known about the psychosocial impact that this has on carers, or what their support needs are during this time.AimTo explore the experiences of family carers who have been involved in making cancer treatment decisions on behalf of a relative with dementia, in particular identifying challenges and support needs.MethodThe authors are conducting semi-structured interviews with carers of people with dementia who have been involved in making decisions about cancer treatment on their behalf. Data is being thematically analysed using an inductive approach. Two researchers will independently verify themes.ResultsThe authors expect to have completed 14–18 interviews and will report their preliminary findings. Family carers experience many difficulties in the context of cancer and dementia, including lack of support when coping with the aftereffects of cancer treatment, lack of awareness among healthcare professionals regarding the authority granted by a lasting power of attorney and the anxiety created by feeling responsible for identifying cancer recurrence.ConclusionThis study will highlight that supporting someone with dementia through cancer treatment, and having to make decisions about it on their behalf, creates unique challenges for carers. Currently there is a significant lack of support for those facing this distressing experience.
Donor-Derived Cell Free DNA: Is It All the Same?
Authors: Melancon Joseph K. , Khalil Ali , Lerman Mark J. 
Published: June 2020

Background
Clinical utility of donor-derived, cellfree DNA (dd-cfDNA) in transplantation has been extensively reviewed, supporting its use as a surveillance tool for the early and accurate detection of allograft injury. Yet studies comparing different assay methods have been lacking.

Methods
Paired sampling of commercially available dd-cfDNA (AlloSure and Prospera) was compared and examined against histology and manufacturer guidance. A total of 76 patients were prospectively assessed, with 11 biopsy sample–proven rejections (antibody-mediated rejection, n=2; T cell–mediated rejection, n=9).

Results
Prospera demonstrated larger measurements of dd-cfDNA in comparison with AlloSure, but this was NS (P=0.12). At current manufacturer recommended diagnostic cutoffs, there was no significant difference in sensitivity, specificity, negative predictive value, or positive predictive value of AlloSure versus Prospera in detecting rejection. AlloSure demonstrated a significantly shorter turnaround time (P=0.01) from blood draw to patient result.

Conclusions
Although dd-cfDNAs are similar, they are not the same. Extensive evidence for dd-cfDNA interpretation remains the key to building clinical utility when considering clinical implementation, and remaining consistent to a single platform is important when creating data comparisons.
Греки, болгары и латиняне: противостояние раннего XIII века во Фракии и Малой Азии
Authors: Kanellopoulos N. 
Published: June 2020

Abstract
The article describes and analyzes the armed conflicts in Thrace and Asia Minor between the Byzantines, the Bulgarians and the Latin Empire of Constantinople during the first decades following the Fourth Crusade. The conflicts took the form of pitched battles, “indirect” warfare and sieges while was common practice between the opponents to form and broke alliances in an attempt to exploit each other’s difficulties. Finally the role of ideology and religion during these wars is briefly investigated.
Аннотация
В статье рассматриваются и анализируются вооруженные конфликты во Фракии и Малой Азии между ромеями, болгарами и Латинской империей Константинополя в первые десятилетия, последовавшие за Четвертым крестовым походом.
Конфликты эти принимали форму открытых сражений, рейдов и осад, причем все эти формы сопровождались заключением и разрывом союзов, призванных эксплуатировать слабость другой стороны. В заключении кратко рассматриваются роли идеологии и религии в указанных конфликтах.
Named for Lewon the Young. The Medieval Name and the Date of Construction of Yilankale
Authors: Григорян С. 
Published: June 2020

Аннотация
Неясность средневекового названия Йиланкале – что по-турецки означает «Змеиная крепость» – являет собой лакуну в исторической географии Армянского королевства Киликии. Величественная крепость, возвышающаяся над драконовидным известняковым обнажением, расположена в сердце Киликийской Равнины, приблизительно в 15 километрах к северо-востоку от места средневекового Мсиса (Eski Misis), ныне поселения Йакапинар.
Автор публикуемого исследования показывает, что в Армянском королевстве Киликии было по меньшей две крепости, названные в честь двух монархов с именем «Левон». Хронологически первая была построена в 1272 году и названа в честь короля Левона II (1270-1289). В первоисточниках она известна как Левонклай, Левонберд, берд Леони и Ламберд. Ее современное название Маран Калеси. Вторая крепость, ныне известная как Йиланкале, по мнению автора, была построена между 19 июня 1320 г. и 26 января 1329 г. и названа в честь Левона IV (1320-1342). Средневековые авторы именовали ее Tłay Lewonin (подразумевая Klay Tłay Lewonin, то есть «Крепость Левона Отрока»), и очевидно также – Тагаворашеном, что означает «Построенная королем». Автор также предлагает именовать указанные крепости Левонклай I и Левонклай II соответственно, в хронологической последовательности их возникновения.
Abstract
The obscurity of the medieval name of Yilankale, which means “Snake Castle” in Turkish, is one of the blind spots of the historical geography of the Armenian kingdom of Cilicia. This magnificent fortress rises above a limestone outcrop located in the heart of the Cilician Plains, about 15 km north-east of the site of medieval Msis (Eski Misis), presently Yakapinar.
The published study clearly shows that there were two fortresses named after two Lewons in the Armenian Kingdom of Cilicia. The first one was built in 1272 and was named after the king Lewon II (1270–1289). It is mentioned as Lewonklay, Lewonberd, berd Lēōni and Lamberd in primary sources. Its modern name is Maran kalesi. The second fortress, now called Yilankale, was constructed between June 19, 1320 and January 26, 1329 and was named after the king Lewon IV (1320–1342). the medieval authors called it Tłay Lewonin (with Klay Tłay Lewonin in mind), apparently also Tʽagaworašen. In addition to these names, the the study’s author proposes to designate the fortresses by the conditional names Lewonklay I and Lewonklay II respectively, in chronological sequence.
EFFECT OF ION PAIRS ON DECREASE THE RISK OF USING SALINE WATER FOR IRRIGATION
Authors: & Esmail Rajab 
Published: June 2020

This investigation was conducted during January, 2018 to April, 2019 to investigate the role of correcting ion pairs and activity in decreasing the risk of saline water for irrigation. The groundwater of (31) wells in Makhmur district were depended in this study .The results indicated that amount of ions contributing in ion pairing was ranged between (0.77 -15.42 mmole l-1) with the mean of 6.56 mmole l-1.and the dominate ion pairs were (CaSO4)0, (MgSO4)0,(MgHCO3)+ and (CaHCO3)+,with the values of 5.00, 4.50, 2.37 and 1.33 mmolc l-1 respectively. The studied saline water in Makhmur district did not suitable for irrigation the soils having low, medium and high permeability, while after correcting ion pairs and activity 14 of the studied saline waters were suitable for irrigation (3 of them for soil having medium permeability and 11 of them for soils having high permeability). It means correcting ion pairs and activity caused removal the risk of 14 saline waters for irrigation or caused decrease the risk of 45% of the studied saline water. Correcting ion pairs and activity caused shifting water class from no suitable for irrigation to suitable for irrigation depending on salinity potential values and Doneen classification.
RESEARCH EFFICIENCY ELEMENT PELTIER
Authors: Бышов Д.Н. , Каширин Д.Е. , Гобелев С.Н. , Бочков П.Э. , Павлов В.В. 
Published: June 2020

В процессе сушки продуктов сельского хозяйства, в частности, продуктов пчеловодства, часто возникает необходимость удаления влаги из теплоносителя (воздушного потока). Эффективное решение этой задачи может быть достигнуто путём использования элементов Пельтье. Элементы Пельтье – это полупроводниковые тепловые насосы, то есть устройства, позволяющие получать отрицательные температуры при протекании через них электрического тока. Для создания эффективных сушильных установок нами были определены рациональные условия электрического питания этих устройств, в частности, род тока и величина потребляемой мощности, обеспечивающие наилучшие значения КПД устройства. Лабораторные исследования проводили в два этапа: исследование мощностных характеристик элемента Пельтье при подключении его к блоку питания, генерирующему постоянный электрический ток; исследование мощностных характеристик элемента Пельтье при подключении к специализированному блоку питания. В качестве опытного образца был исследован элемент Пельтье марки «TEC1-12705». В статье описана методика проведения исследований, структурная и электрическая схемы лабораторной установки, а также её общий вид. По результатам исследования были получены математические модели и графические зависимости разницы температур Dt от потребляемой мощности Р. Полученные результаты позволили установить количественные характеристики исследуемых процессов.
In the process of drying agricultural products, in particular bee products, it is often necessary to remove moisture from the coolant (air flow). An effective solution to this problem can be achieved by using Peltier elements. Peltier elements are semiconductor heat pumps, that is, devices that allow to obtain negative temperatures when an electric current flows through them.
To create efficient drying plants, we have determined the rational conditions for the electrical supply of these devices. In particular: current sort; the amount of power consumption, providing the best values of the efficiency of the device. Laboratory studies were carried out in two stages: the study of the power characteristics of the Peltier element when connected from a power supply generating a direct electric current; the study of the power characteristics of the Peltier element when connected from a specialized power supply. The Peltier element of the brand "TEC1-12705" was studied as a prototype. The article describes the methodology of research, structural and electrical circuits of the laboratory installation, as well as its General appearance. According to the results of the study, graphical dependences and mathematical models of the temperature difference ∆t from the power consumption were obtained. The Obtained results allowed to establish the quantitative characteristics of the studied processes.
RELATIONSHIP OF HOW PARENTS EDUCATE CHILDREN WITH THE ABILITY TO TAKE THE DECISION OF NURSING STUDENTS
Authors: Huda Nurul , Cahyono Bagus Dwi , Toha Mukhammad 
Published: June 2020

Background: The family is the most basic social institution to print human qualities, even the good and bad development of children determining by the formation of a person in the family. One of the tasks of child development is achieving decision-making abilities. But the fact is that teenagers who are represented by students often do the wrong thing because of their inability to make the right decision. The action can be non-academic or academic. The phenomenon of how to educate children at this time is also getting worse, and this can seek from the increasing number of cases of violence against children.Objectives: The purpose of this study was to determine the relationship between parents' educational patterns and decision-making abilities in nursing students at the Nursing Academy of Pasuruan.Methods: This research used observational analytic study with a cross-sectional design. The population was the student of Nursing Academy Pasuruan as many as 200 students. A sample of 80 students were selected by simple random sampling. Data were collected using two questionnaires that have been tested for validity and reliability, with item-total correlations > 0.20 and Cronbach alpha > 0.60 and analyzed by Spearman ranks.Results: The results of the study found that there is a relationship between parents' educational patterns and decision-making abilities in nursing students (p > 0.05). Positive experiences will encourage children to continue to look for better decision-making strategies in the future.Conclusion: Further research on parents' educational patterns needs to be done with more holistic measurements, namely relating to efforts to meet biological, psychological, social, and spiritual needs.Â Keywords: Parentsâ€™ Educational Patterns, Decision-Making Abilities, Nursing Students
Implementasi Jenjang Karir Perawat Klinik terhadap Kepuasan Pasien: studi rumah sakit Pertamina Cirebon
Authors: Lesmana Nevi Kuspiana , Setiawan Asep , Murtiningsih Murtiningsih 
Published: June 2020

Pelaksanaan jenjang karir perawat dimulai sejak adanya regulasi yang mengatur sistem jenjang karir perawat di Indonesia. Penelitian ini bertujuan untuk mengetahui pengaruh faktor individu pasien dan implementasi jenjang karir perawat klinik terhadap kepuasan di Rumah Sakit Pertamina Cirebon. Desain penelitian cross-sectional dengan jenis korelasional. Jumlah sampel sebanyak 96 responden sebagai pasien rawat inap. Pengumpulan data penelitian menggunakan intrumen kuesioner dan wawancara. Analisis data menggunakan uji Spearman’s dan t-Independent. Hasil penelitian membuktikan bahwa implementasi jenjang karir perawat klinik memberikan pengaruh terhadap dimensi kepuasan pasien dengan p value 0.000. Oleh sebab itu direkomendasikan kepada manajemen Rumah Sakit dalam menerapkan jenjang karir perawat klinik perlu adanya komitmen pimpinan, alokasi biaya, sumber daya perawat yang memadai, peningkatan kesejahteraan perawat dan melengkapi sarana serta pra sarana.
Catatan PenerbitPolekkes Kemenkes Kendari menyatakan tetap netral sehubungan dengan klaim dari perspektif atau buah pikiran yang diterbitkan dan dari afiliasi institusional manapun.
PendanaanPenulis tidak menerima pendanaan yang sifatnya spesifik untuk kajian ini.
Konflik KepentinganPenulis tidak memiliki konflik kepentingan.
Berbagi DataKuesoioner penelitian dan hasil uji validitas-reliabilitasnya tersedia secara umum di https://doi.org/10.6084/m9.figshare.12442910
FORMULATION AND EVALUATION OF HARD GELATIN CAPSULES CONTAINING Bacopa Monnieri
Authors: Kaur Darshan 
Published: June 2020

Introduction: The present work deals the formulation of hard gelatin capsules containing granules of Brahmi (Bacopa monnieri). Bacopa monnieri is used in Ayurvedic traditional medicine to improve memory and to treat various ailments. The aim of the project is to achieve immediate release of drug from dosage form to achieve therapeutic efficacy and patient compliance. Hard gelatin capsules offer rapid drug release and protection from atmospheric oxygen. Materials and methods: In this work we have prepared the granules of Brahmi and filled into the empty hard gelatin capsule shells. The hard gelatin capsules were then evaluated for dissolution studies, disintegration study, drug content and weight variation. Results and Discussion: After dissolution study it was found that 93.46% of Brahmi was released within 90 min. The kinetics of drug release was also studied and it was found to follow Korsmeyer Peppas model.
The Synthesis, Characterization and Evaluation of Anti-microbial activity of some novel 1,2,4- trizaoles
Authors: Martin Alex 
Published: June 2020

Some novel 4-(aryliidineamino)-5-(1-(4-isobutylphenyl) ethyl)-4-yl-4H-1,2,4-triazole-3-thiols were prepared from the reaction of carbon-di-sulphide and hydrazine hydrate in water to produce thiocarbohydrazides. The thiocarbohydrazides is then refluxed with ibuprofen for 2 hour, followed by cooling to room temperature and washing with sodium bicarbonate solution to produce 5-(1-(4-isobutylphenyl) ethyl)-4H-1,2,4- triazole-3-thiole. It is then refluxed with different aldehydes in the presence of ethanol and HCl to produce the title compounds. The synthesized compounds are recrystallized from ethanol and are analyzed for their physical and spectral data. They are screened for their anti-microbial activity and it was found that the title compounds are found to have moderate to good antimicrobial activity.
A GREEN LIGHT FOR MARINE BIOTECHNOLOGY IN FISHERIES
Authors: Kuznetsov Yuriy 
Published: June 2020

Bionic principles of technologies invention copying the organization of living
systems on different levels give a good example of cognitive science application
for nature management to achieve the synergistic effect. The fisheries still
uses the mechanistic approach and extensive principles to problem solving
what is leading to the deep technological crisis. To change the existing catches
methodology a modern hydrobionics means are proposed. They allow to
explain relations between biotic and abiotic factors in catches dynamics, the
nature of problems and stacks in numerous prospective themes in fisheries.
METODE VARIABEL COSTING GUNA PENENTUAN HARGA JUAL PADA UD. SEJAHTERA DESA SERUT PANTI
Authors: Prabawati Achadyah , Hasbiyallah Abdul Ghovur 
Published: June 2020

Penetapan harga jual yang dilakukan oleh manajer merupakan keputusan yang harus mempertimbangkan tidak hanya keuntungan saja, namun juga kelangsungan hidup perusahaan, berpedoman dengan pengeluaran biaya, dan tetap menjaga kesejahteraan karyawan. Dengan banyaknya hal yang harus diperhitungkan perlu adanya metode untuk membantu manajer mengambil keputusan menentukan harga jual. Metode variable costing membuat manajer mampu untuk memperbaiki penelusuran biaya dengan cara memfokuskan pada biaya yang berperilaku variabel terhadap pembentukan produk dan jasa.Penelitian ini memiliki tujuan untuk mengetahui bagaimana metode variable costing apabila diterapkan pada UD. Sejahtera dalam menetukan harga jual. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan studi kasus. Metode pengumpulan data yang digunakan adalah dokumentasi, wawancara dan observasi. Jenis data yang digunakan adalah data primer dan data sekunder, sedangkan metode analisanya menggunakan analisa kualitatif.Hasil penelitian ditemukan bahwa UD. Sejahtera terlalu tinggi dalam menetukan harga jual sehingga menyebabkan melemahnya pemasaran, akibatnya jumlah tenaga kerja ikut berkurang yang mengakibatkan produktivitas tempat usaha menurun. Setelah penulis melakukan analisa diketahui metode variabel costing lebih tepat digunakan pada UD. Sejahtera hal ini dibuktikan berdasarkan HPP dan harga jual antara metode variable costing dapat dijadikan tolok ukur atau batas minimal perolehan laba, selain itu presentase mark up-nya lebih tinggi jika dibndingkan metode lain yaitu metode full costing.
Audit Delay, Faktor Auditee, Komisaris Independen, dan Faktor Auditor
Authors: Imanniar Hartika , Majidah  
Published: June 2020

Aturan telah disusun dalam aturan OJK No.29/PJOK.04/2016 mengenai batas waktu penyampaian laporan audited, bertujuan untuk menjaga ketepatan penyampaian laporan audited, sehingga dapat menjadi informasi yang berguna. Penelitian ini bertujuan untuk mengetahui pengaruh faktor auditee (good news, financial distress, kompleksitas perusahaan), komisaris independen, dan faktor auditor (fee audit reputasi auditor) terhadap audit delay. Populasi penelitian ini adalah sektor properti, real estat, dan konstruksi bangunan pada BEI periode 2015-2018. Terdapat 160 sampel menggunakan purposive sampling, 66 diantaranya merupakan data outlier, sehingga diperoleh 94 sampel akhir. Data penelitian dianalisis dengan statistik deskriptif dan regresi data panel.
Hasil penelitian menunjukkan bahwa good news, financial distress, komisaris independen, kompleksitas perusahaan, fee audit, dan reputasi auditor berpengaruh simultan terhadap audit delay. Secara parsial, kompleksitas perusahaan berpengaruh positif terhadap audit delay, fee audit berpengaruh negatif terhadap audit delay, sedangkan good news, financial distress, komisaris independen, dan reputasi auditor tidak berpengaruh terhadap audit delay.
Pattern of Self-Medication with Prescription Medicines Among Residents of Ilorin in North Central Nigeria
Authors: Jamiu Muslim Olakunle , Iyabode Fatima AbdulAzeez , Onozare Aliyu Fullaila 
Published: June 2020

Background: The challenge posed by inappropriate use of medicine is of global concern. It is associated with patient using his discretion to choose the type of medication to self-treat a perceived ailment and the choice of medication usually devoid of health care professional input.
Objective: The significance of this study was to assess the pattern of self-medication with selected prescription medicines among residents of Agbo-Oba area of Ilorin, Kwara State.
Method: The method was a descriptive cross-sectional study of residents of Agbo Oba area of Ilorin between January to May 2019 with self-designed validated questionnaire. Convenient sampling method was used to select the participant who met the criteria for selection.
Results: The mean age of the respondents was 38.5±11.8 with minimum age of 19 and maximum age of 70 years. The most occurring age group was 26-35 years and primary school level of education, and artisan/trader were the most predominant in self-medication. Among the prescription medicines, antibiotics were the most self-used followed by steroids and cyproheptadine. Females were shown to practice self-medication more than their male counterpart. Marital status and level of education were factors that influenced awareness of risk factors associated with self-medication among the study participants, p-value = 0.017 and 0.039, respectively.
Conclusion: The prevalence of self-medication with prescription medicines was high and appeared to be more among female than male. Specifically, female misuse oral corticosteroids and cyproheptadine more and marital status and occupation type are strong predictors of their awareness of potential risks associated with self-use of prescription medicines.