bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Women’s Exposure to Mass Media for Health Care Information in Ethiopia. A Case-control Study
Authors: Gashu Kassahun Dessie , Yismaw Ayenew Engida , Gessesse Dereje Nibret 
Published: October 2020

Abstract
Introduction: Mass media are often essential to communicate health messages. Women’s exposure to mass media remained low in Ethiopia. Evidence was scarce on underlined factors for enhancing women’s exposure to mass media. Objective: This study aimed to assess factors associated with women’s exposure to mass media in Ethiopia. Methods: The study was a secondary data analysis of the Ethiopian demographic and health survey 2016. A case-control study applied with frequency matching by place of residence and women’s educational levels using a 1:1 ratio. A total of 9885 participants (4824 cases and 5061 controls) were involved in the study. Cases were women who had exposure and controls were who did not have exposure to mass media. Women’s exposure to mass media is defined as the total number of women aged 15-49 who report exposure to either radio, television, newspapers, or magazines at least once a week. Logistic regressions analysis was conducted and the level of statistical significance was determined by a p-value of less than 0.05to identify factors associated with women’s exposure to mass media.Result: Being in Women’s age group 30-34 years (AOR=1.19,95% C.I:1.04-1.35), having own mobile phones (AOR=1.92,95% C.I:1.71-2.15), women ever used internet (AOR=1.56,95% C.I:1.13-2.13), Women in the female-headed household (AOR=0.76,95%C.I:0.68-0.86),Women in middle (AOR=1.48,95%C.I:1.25-1.76), richer (AOR=2.13,95%C.I:1.82-2.49) and richest (AOR=2.67,95% C.I:2.22-3.21) wealth index, and women visited by health care provider (AOR=1.41,95% C.I:1.17-1.71) were factors affecting women’s exposure to mass media.Conclusion: Women’s access to mobile phones, internet, and care provider counseling were facilitating factors for exposure to mass media. Younger age women, lower wealth quantile, and female headship in the household were risk factors for the non-exposure of women to mass media. Empowering household wealth and improving access to ICT could improve women’s exposure to mass media.
WITHDRAWN: The Prevalence of Insomnia Symptoms and Its Association With Quality of Life Among Clinically Stable Older Patients With Psychiatric Disorders in China During the COVID-19 Outbreak
Authors: Xu Xiuying , Li Wen , Zou Siyun , Li Yulong , Wang Huan , Yan Xiaona , Du Xiang-Dong , Zhang Lan , Zhang Qinge , Cheung Teris , Ungvari Gabor S. , Xiang Yu-Tao 
Published: October 2020

Abstract
Aims: The negative impact of the COVID-19 outbreak on sleep quality of clinically stable psychiatric patients is unknown. This study examined the prevalence of insomnia symptoms and its association with quality of life (QOL) in clinically stable older psychiatric patients during the COVID-19 outbreak. Methods: This multicenter, cross-sectional study involved older patients attending maintenance-treatment at the outpatient departments of four major psychiatric hospitals in China. Patients’ basic socio-demographic and clinical characteristics were collected. Insomnia symptoms, depressive symptoms, and QOL were assessed with the Insomnia Severity Index (ISI), Patient Health Questionnaire (PHQ-9), and two items of the World Health Organization Quality of Life-brief version (WHOQOL-BREF), respectively. Binary logistic regression analysis was conducted to examine the independent associations of socio-demographic and clinical variables with insomnia symptoms, while the association between insomnia symptoms and QOL was examined with analysis of covariance.Results: A total of 941 patients were recruited. The prevalence of insomnia symptoms was 57.1% (95% CI: 53.9-60.2%). Analysis of covariance revealed that QOL was significantly lower in patients with insomnia symptoms compared to those without them (P<0.01). Multivariate logistic regression analysis showed that insomnia symptoms were positively and independently associated with more severe depressive symptoms (P<0.01, OR=1.31, 95%CI: 1.26-1.37). Compared to patients with major depressive disorder, those with other psychiatric diagnoses had significantly higher prevalence of insomnia symptoms (P=0.03, OR=1.47, 95%CI: 1.02-2.12).Conclusions: Insomnia symptoms were common among clinically stable older psychiatric patients during the COVID-19 outbreak. Considering their negative impact on QOL, regular assessment and treatment of insomnia symptoms need to be addressed in this population.
In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infection
Authors: Ahmadi Amirhossein , Moradi Sharif 
Published: October 2020

Abstract
COVID-19 has currently become the biggest challenge in the world. There is still no specific medicine for COVID-19, which leaves a critical gap for the identification of new drug candidates for the disease. Recent studies have reported that the small-molecule enoxacin exerts an antiviral activity by enhancing the RNAi pathway. The aim of this study is to analyze if enoxacin can exert anti-SARS-CoV-2 effects. We exploit multiple computational tools and databases to examine (i) whether the RNAi mechanism, as the target pathway of enoxacin, could act on the SARS-CoV-2 genome, and (ii) microRNAs induced by enoxacin might directly silence viral components as well as the host cell proteins mediating the viral entry and replication. We find that the RNA genome of SARS-CoV-2 is a suitable substrate for DICER activity. We also highlight several enoxacin-enhanced microRNAs which could target SARS-CoV-2 components, pro-inflammatory cytokines, host cell components facilitating viral replication, and transcription factors enriched in lung stem cells, thereby promoting their differentiation and lung regeneration. Finally, our analyses identify several enoxacin-targeted regulatory modules that were critically associated with exacerbation of the SARS-CoV-2 infection. Overall, our analysis suggests that enoxacin could be a promising candidate for COVID-19 treatment through enhancing the RNAi pathway.
Development and Preliminary Evaluation of Chinese School-aged Children’s Eating Behavior Scale
Authors: Zhang Hao , Jiang Xun , Zhang Yu-Hai , Yuan Jing , Tan Zhi-Jun , Xu Tong , Shang Lei 
Published: October 2020

Abstract
Background: The objective of this study was to develop a scale to assess eating behaviors of school-aged children (6-12 years old) in China. Methods: To develop the scale, we reviewed the literature and conducted qualitative interviews. The draft scale contained 115 items and went through three evaluations among three groups of caregivers (n = 140, 400, 700) selected from suburban and urban kindergartens in Xi’an, Hanzhong, and Yanan, China, from March 2017 to October 2018. The psychometric properties of the score were assessed using exploratory, confirmatory factor analysis, and variability analysis. Results: The final scale consisted of 46 items across 8 dimensions including food fussiness, satiety responsiveness, food responsiveness, bad eating habits, susceptible diet, restrained eating, enjoyment of food, and junk food addiction. The total cumulative variance contribution rate was 52.16%. The scale dimensions and Cronbach’s α coefficients, Guttman split-half reliability, and test- retest reliability were all above 0.65. The fitting indices for the confirmatory factor analysis were all close to 1. The scores for education of caregiver, family structure, and the body mass index of children were different among dimensions and groups, thus suggesting good discriminative utility. Conclusions: All the results indicated that the scale has good reliability and construct validity for evaluating the eating behaviors of school-aged children in China.
Socioeconomic Disparities of Low Birth Weight in Rural Indonesia
Authors: Laksono Agung Dwi , Wulandari Ratna Dwi , Matahari Ratu 
Published: October 2020

Abstract
Background: Poverty is estimated to increase a mother's chances of giving birth to a low birth weight baby (LBW). Objective: This study aimed to analyze the socioeconomic disparities of LBW in rural Indonesia.Methods: Mother aged 15-49 years old who had given birth in the last 5 years in rural Indonesia was used as the unit of analysis. With stratification and multistage random sampling found 19,283 mothers were sampled. The variables analyzed included LBW, socioeconomic, age, marital, education, employment, and antenatal care (ANC). The binary logistic regression test was used at the final stage to determine the existence of disparities.Results: The results show that the mother with the poorer wealth status was 0.686 times more likely than the poorest mother to give birth to an LBW baby. Mothers with middle wealth status were 0.688 times more likely than the poorest mothers to give birth to LBW babies. Mothers with richer wealth status were 0.621 times more likely than the poorest mothers to give birth to LBW babies. Finally, the richest mothers were 0.452 times more likely than the poorest mothers to give birth to LBW babies. The results of this analysis inform that the better the socioeconomic of mothers, the lower the likelihood of giving birth to LBW babies. Apart from socioeconomics, the analysis also found two other predictors of LBW in rural Indonesia, namely education level and ANC visits.Conclusion: It was concluded that there were socioeconomic disparities of LBW in rural Indonesia.
Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability
Authors: Wilkinson Carol , Nelson Charles A 
Published: October 2020

Abstract
Background: The lack of identified clinical biomarkers in Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, has limited the successful translation of bench-to-bedside therapeutics. While numerous drugs have shown promise in reversing synaptic and behavioral phenotypes in mouse models of FXS, none have demonstrated clinical efficacy in humans. Electroencephalographic (EEG) measures have been identified as candidate biomarkers as EEG recordings of both adults with FXS and mouse models of FXS consistently exhibit increased resting-state gamma power. However, the developmental timing of these EEG differences is not known as thus far EEG studies have not focused on young children with FXS. Further, understanding how EEG differences are associated to core symptoms of FXS is crucial to successful use of EEG as a biomarker, and may improve our understanding of the disorder. Methods: Resting-state EEG was collected from FXS boys with full mutation of Fmr1 (32-84 months old, n=11) and compared with both age-matched (n=12) and cognitive-matched (n=12) typically developing boys. Power spectra (including aperiodic and periodic components) were compared using non-parametric cluster-based permutation testing. Associations between 30-50Hz gamma power and cognitive, language, and behavioral measures were evaluated using Pearson correlation and linear regression with age as a covariate. Results: FXS participants showed increased power in the beta/gamma range (~25-50Hz) across multiple brain regions. Both a reduction in the aperiodic (1/f) slope and increase in beta/gamma periodic activity contributed to the significant increase in high-frequency power. Increased gamma power, driven by the aperiodic component, was associated with better language ability in the FXS group. No association was observed between gamma power and parent report measures of behavioral challenges, sensory hypersensitivities, or adaptive behaviors. Limitations: The study sample size was small, although comparable to other human studies in rare-genetic disorders. Findings are also limited to males in the age range studied. Conclusions: Resting-state EEG measures from this study in young boys with FXS identified similar increases in gamma power previously reported in adults and mouse models. The observed positive association between aperiodic gamma power and language supports hypotheses that alterations in some EEG measures may reflect ongoing compensation.
Contributions of traffic and industrial emission reductions to the air quality improvement after the lockdown of Wuhan and neighboring cities due to COVID-19
Authors: Feng Xiaoxiao , Zhang Xiaole , He Cenlin , Wang Jing 
Published: October 2020

Abstract
Wuhan was locked down from January 23rd to April 8th, 2020 to prevent the spread of the novel coronavirus disease 2019 (COVID-19). Both the public and private transportations in Wuhan and its neighboring cities in Hubei Province were suspended or restricted, and the manufacturing industry was partially shut down. This study collected and investigated the ground monitoring data to prove that the lockdowns of the cities had significant influences on the air quality in Wuhan. The combined Weather Research and Forecasting Model (WRF) and Community Multiscale Air Quality Modeling System model (CMAQ) was used to evaluate the emission reduction from transportation and industry sectors and associated air quality impact. The results show that the emission from the transportation and industry sector reduced after the lockdown, while the emission from the industry sector reduced further after February 9th. The reduction rate of pollutant concentration was 9.7%, 9.0%, 2.2%,18.4% and 13.4% from transportation, and was 48.5%, 50.0%, 63.8%, 65.6% and 40.8% from industry for PM2.5, PM10, SO2, NO2 and CO, respectively, compared to the ‘business as usual’ case during January and February in Wuhan. The industry shut down contributed significantly more to the pollutant reduction than the restricted transportation.
SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo
Authors: FUKUDA Hiroshi , SEYAMA Kuniaki , ITO Kanami , HORI Satoshi , WAKITA Mitsuru , SAITO Kaori , SHIDA Yuka , NAGURA Rie , HASEGAWA Mayu , KANEMOTO Chiaki , TOKUHARA Mayumi , OKAJIMA Katsunobu , YOSHIKAWA Yukio , KATSUTA Narimasa , YAMAMOTO Takamasa , AI Tomohiko , IDEI Mayumi , MISAWA Shigeki , NAITO Toshio , MIIDA Takashi , SATO Hiroyuki , HATTORI Nobutaka , TABE Yoko , TAKAHASHI Kazuhisa 
Published: October 2020

Abstract
Healthcare workers (HCWs) are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to assess the seroprevalence of SARS-CoV-2 in HCWs working in a frontline hospital in Tokyo, Japan. In this observational cohort study, screening was offered to agreed HCWs, including medical, nursing, and others, as part of a mandatory health checkup. The screening test results and clinical characteristics of the participants were recorded. The antibody seroprevalence among the 4,147 participants screened from July 6 to August 21 2020, was 0.34 % (14/4,147). There was no significant difference in seroprevalence between frontline HCWs with a high exposure risk and HCWs in other settings with a low exposure risk. Of those seropositive for SARS-CoV-2, 64% (9/14) were not aware of any symptoms and had not previously been diagnosed with COVID-19. In conclusion, this study provides insights into the extent of infection and immune status in HCWs in Japan, which has a relatively low prevalence of COVID-19.
Intestine motility, secretion, and constipation treatment principles
Authors: Shulpekova Yu. O. , Rusyaev V. Yu. , Sheptulin D. A. , Shulpekova N. V. 
Published: October 2020

Introduction. Constipation is a derangement of the motor, secretory and/or evacuation function of the colon. The same symptoms are recorded in at least 20% of the population in the developed countries – as those occurring sporadically or for a long period.Basic content. The secretory function of the colon significantly affects stool consistency and its free movement. The secretion increases by 8–10 times in the presence of local mechanical irritation. Intestinal mucus is produced by colonic goblet cells. The frequency, time of defecation and stool consistency is in large part determined by the motor function of the colon. The relation of various types of contraction varies depending on the main function – propulsion or mixing. Rhythmic phasic contractions in the colon generate a pendular movement with slow propulsion of the contents and absorption of water. The tonic contractions enhance the mixing effect of weak rhythmic contractions. The propulsive contractions are specifically attributed to the lower gastrointestinal tract and occur spontaneously. They occur quite regularly, from 2 to 10 times a day, and ensure the propulsion of intestinal contents over great distances in the colon. When reaching the sphincter area, such wave causes its relaxation by mechanisms of descending inhibition. The dietary regime and adequate intake of carbohydrates with various chain lengths, including dietary fiber, as well as flavonoids and other components that modify peristaltic activity and secretion, play an important role in the regulation of intestinal secretion and peristalsis. The drugs enhancing intestinal secretion and peristalsis, such as bisacodyl and sodium picosulfate, are also used to treat constipation. These substances hydrolyse into bis-(p-hydroxyphenyl)-pyridyl-2-methane in the intestine, which, upon contact with the receptors in colonic mucosa, stimulates propulsive activity and increases intestinal secretion. The selective action of sodium picosulfate is confined to the colon.Conclusion. Pharmacological and non-pharmacological treatments for constipation are aimed at maintaining and enhancing the natural propulsive contractions of the colon and intestinal secretion.
Ustekinumab in patients with Crohn’s disease with extraintestinal manifestations (psoriasis)
Authors: Makarchuk P. A. , Lomakina E. Yu. , Belousova E. A. 
Published: October 2020

Ulcerative colitis and Crohn’s disease are severe immune-mediated diseases. Extraintestinal manifestations of inflammatory bowel disease (IBD) significantly increase the burden to the patient. The most common extraintestinal manifestations include erythema nodosum, ankylosing spondylitis, and primary sclerosing cholangitis. Some of the extraintestinal manifestations depend on the activity of the inflammatory process in the intestine and can be reversed during treatment of IBD, while the others require specific therapy, since it does not depend on the degree of inflammation in the intestine. Patients with IBD are at increased risk of developing complications caused by other organ systems, such as osteoporosis, venous thromboembolism, and cardiovascular diseases. Immunemediated diseases such as multiple sclerosis and psoriasis have been associated with inflammatory bowel disease, but these conditions can also be complications of IBD therapy. In this regard, patients and healthcare providers should exercise vigilance in identifying extraintestinal manifestations and complications of IBD, and the therapy should be aimed both at treating the underlying disease and reversing extraintestinal manifestations as much as possible. Interleukin-12/23 is an important cytokine in the inflammatory process development in the immune-mediated diseases. Ustekinumab is effective in treating not only IBD, but also psoriasis by blocking interleukin 12/23. The drug shows a higher survival index of the therapy as compared to tumour necrosis factor-α inhibitors. The article describes the experience of using ustekinumab in severe concomitant pathology – Crohn’s disease in the form of ileocolitis and psoriasis vulgaris with initial manifestations of psoriatic arthritis against ineffectiveness of tumour necrosis factor-α inhibitors.
Adalimumab and azathioprine in the prevention of postoperative crohn’s disease recurrence
Authors: Poletova A. V. , Shapina M. V. 
Published: October 2020

Introduction. Despite improvements in earlier diagnosis and the development of conservative therapy for Crohn’s disease (CD), approximately 70%–80% of patients undergo surgical treatment for complications. Surgical treatment is not a cure for this disease. The question of choosing therapy as a prevention of postoperative relapse of CD is still open. AIM. To compare the effectiveness of immunosuppressive and biological therapy as a postoperative preventive therapy.Materials and methods. The retrospective study included 125 patients with CD who underwent surgery in terms from 2010 to 2017. After the operation, patients were divided into 3 groups. Patients from the first group received azathioprine, from the second - adalimumab, and patients from the third group were prescribed combined therapy with azathioprine and adalimumab. Clinical, endoscopic, and laboratory data for analysis of disease activity was collected 3, 6, and 12 months after surgery.Results. During the year of therapy in all three groups relapses occurred in only 22 patients (22/125 17.6%). There were no statistically significant differences between the groups at any of the assessment stages. There was also no statistically significant correlation between the presence of risk factors and relapses.Conclusion. Our research has shown that the choice of anti-relapse therapy depending on risk factors is controversial. However, active endoscopic monitoring is important regardless of the treatment strategy. Also, our data allow us to conclude that the frequency of relapses of CD during the postoperative preventive therapy does not depend on the specific drug chosen, as well as on demographic and anamnestic parameters.
Water-resource stress on the Spanish Costa del Sol: policy requirements to improve supply security
Authors: Argamasilla-Ruiz Manuel , Foster Stephen , Andreo-Navarro Bartolome 
Published: October 2020

Abstract
The Costa del Sol, in common with many Mediterranean (and similar) coastal areas, is having to face increasing water-resource stress as a result of global warming and land-use change, coupled with extremely high peak water demand resulting from large tourist numbers and summer climatic factors. An assessment is presented of current water-supply provision, possible measures to enhance the resilience of the water-supply system (focusing on improved use of groundwater storage), and the institutional challenges confronting their implementation.
ANCESTRALIDADE AFROSERGIPANA: EXPLORANDO AFETO E MEMÓRIA ATRAVÉS DE UM ENSAIO “META-FOTOGRÁFICO”
Authors: Freitas Luciano 
Published: October 2020

O presente artigo apresenta, de forma resumida, o processo de produção de um ensaio fotográfico, explorando metalinguagem, ancestralidade e oralidade, a partir de um recorte de gênero articulado à realidade da comunidade afrodescendente em Sergipe. O referido ensaio, produzido de forma colaborativa com homens e mulheres engajadas nas artes na cultura e na luta antirracista, da capital de Sergipe, Aracaju, foi planejado para ser exposto em forma de varal fotográfico itinerante.
(Ensaio fotográfico anexo)