bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ATUALIDADE HISTÓRICA DA CATEGORIA POLÍTICA NA ONTOLOGIA DE LUKÁCS
Authors: Triginelli Daniel Handan , Jesus Sara Tatiane de 
Published: June 2020

O presente trabalho surge como resultado do projeto de pesquisa “A Categoria Política em ‘Para uma Ontologia do Ser Social’, de György Lukács”, financiado pelo Programa Institucional de Apoio à Pesquisa (PAPq-UEMG), no qual se analisou a obra do filósofo húngaro György Lukács, sendo Para uma Ontologia do Ser Social, em especial, o capítulo dedicado ao estudo sobre “O ideal e a ideologia”, além do suporte de outras fontes. Não obstante, pretendeu-se compreender a importância da categoria política no que diz respeito ao desenvolvimento histórico humano, ou seja, o esforço em contribuir para a atualização da compreensão e influência que ela apresenta no desenvolvimento do ser social em seu processo contínuo de reprodução. Na mesma direção, almejou-se apreender os efeitos que os desdobramentos que esta categoria, a política, promove no momento histórico atual em que estamos inseridos, pois, através dessa análise, verificaremos que a humanidade se encontra diante da hegemonia da ordem do capital.
Mucin producing carcinomas of the breast. Cytological diagnostics
Authors: Grigoruk O. G. , Moskvina T. A. , Bazulina L. M. , Sigitova E. S. , Stepanova A. S. , Ilinskiy V. K. , Ponomarev T. V. , Bakharev S. Yu. 
Published: June 2020

The aimof the study is to estimate potentiality of the cytological diagnostics of different types of mucin producing carcinomas of the breast.Materials and methods. Cytological evidences of the investigation of 35 patients with mucinous mass in cytological specimens were studied. Different types of mucinous carcinomas which had been diagnosed by cytological method were identified retrospectively.Results. “Pure” mucous carcinomas were divided into two types: hypocellular (A) and hypercellular (B) (n = 9 (25.7 %) and 14 (40 %), respectively). Mixed carcinomas (mucous carcinoma with invasive no special type carcinoma) were noticed of 12 women (34.3 %). 24 cell characteristics of mucin producing carcinomas were identified. Some cytological characteristics were estimated due to multiple factor analysis and discriminant analysis.Conclusions. Investigation results indicated that cytological technique is a high-quality diagnostic method. The fraction of correct classification of mucous carcinoma types based on discriminant analysis was 92–99 %.The study protocol was approved by the biomedical ethics committee of The Altai State Medical University, Ministry of Health of Russia.
The place of CDK4/6 inhibitors in real clinical practice for patients with hormone-positive HER2-negative advanced breast cancer: opinion of Moscow’s oncologists
Authors: Zhukova L. G. , Mukhina M. A. 
Published: June 2020

The use of CDK4/6 inhibitors in combination with endocrine therapy (aromatase inhibitors and fulvestrant) allowed us to radically change our understanding of opportunities in the treatment of hormone-positive HER2-negative advanced breast cancer and determine optimal therapy sequencing. The results of randomized clinical trials and over 5-years accumulated international experience in the use of CDK4/6 inhibitors in real clinical practice prove that the use of combinations with CDK4/6 inhibitors can achieve significant efficacy results and increase the survival rates when prescribed in 1 and 2 lines of treatment.In this paper, we present the results of a survey conducted in July–October 2019 among 48 oncologists in Moscow, that were asked to choose, in their opinion, the most preferable patient’s profile and molecular and biological features of hormone-positive HER2-negative advanced breast cancer, in which the use of combination therapy with CDK4/6 inhibitors will provide the greatest benefit.Conflict of interest. MD M.A. Mukhina is the medical director of oncology in the Eurasia and Baltic region of Pfizer Innovations Company
On the old archive of the Lăpușna County Court and on its 2345 documents from the 15th–19th centuries
Authors: Zahariuc Petronel 
Published: June 2020

On July 10, 1926, the First-President of the Lăpușna Court, judge Eugen Ionescu-Dârzeu and the regional manager of the Romanian Archives, L. T. Boga, signed the acceptance protocol for the old archive of the Lăpușna Court, which comprised around 2,345 documents. During the inventorying process, L. T. Boga and the archivists in Kishinev typed several copies of an opis, of which one (copy No. 3)—which I feature here—ended up in the collections of the Romanian Academy Library, probably from the archive of judge E. Ionescu-Dârzeu. Currently, this collection was integrated to Fund 220 within the Kishinev Archives. Following a global appraisal of the documents published from this archive, I may state that around a quarter of them (approximately 500) were edited, mainly by L. T. Boga and by the editors of the collection Moldova în epoca feudalismului. It is the responsibility of present or future researchers to edit integrally or as abstracts, on a theme-based or chronology-based approach, other documents within this collection.
Until the fulfilment of this desideratum, the critical editing of this opis introduces in the scientific circuit around 2,000 documents, as abstracts. This important archival work tool comprises unpublished information about the history of Moldova, mostly of the regions left from the Pruth River, before and after 1812, concerning both the political and social history and the local history, the toponymy or the genealogy.
¿LA ESPECTROSCOPIA DE INFRARROJO CERCANO (NIRS) PODRÍA SER ÚTIL EN EL MONITOREO HEMODINÁMICO DEL PACIENTE CRITICO PEDIÁTRICO?
Authors: Puentes López Sindy Paola , Zárate Vergara Andrea Carolina , Tirado Pérez Irina Suley , Garcia Orozco Yorladis , Ariza Álvarez Yamid 
Published: June 2020

Introducción: La oximetría cerebral no invasiva utiliza la tecnología NIRS (“near infrared spectroscopy”) para medir la saturación de oxígeno en una pequeña región de los vasos cerebrales corticales. Refleja el 75% volumen de oxigenación cerebral venosa y el 25% volumen de oxigenación cerebral arterial. Objetivo: Hacer una descripción breve sobre oximetría cerebral no invasiva mediante la tecnología NIRS (“near infrared spectroscopy”). Aunque esta técnica se describió hace más de 25 años, su uso es cada vez más frecuente siendo un fenómeno reciente. Comentarios: La saturación regional cerebral de oxígeno (rSO2c), al igual que la saturación pulsátil arterial periférica de oxígeno, se mide por espectrometría. Se basa en el hecho de que la hemoglobina oxigenada absorbe menos luz roja y más luz infrarroja que la hemoglobina. Es un método sencillo para identificar el límite inferior de la autorregulación, el punto por debajo del cual el flujo sanguíneo cerebral y la oxigenación tisular se hacen dependientes de la presión. Conclusiones: Los valores obtenidos de rSO2c representan el estado de oxigenación de los cromóforos del lecho vascular cerebral del compartimento venoso. Los cambios en la oximetría cerebral dependen del balance entre aporte y consumo de oxígeno.
MALFORMACIONES CONGÉNITAS DEL TRACTO DIGESTIVO: REPORTE DE CASO DE MALROTACIÓN INTESTINAL, BANDAS DE LADD Y ATRESIA ILEAL EN EL NEONATO
Authors: Manjarres Gil Zulay , Mastrodomenico Vargas Maleivy , Del Valle Jassan Edgardo 
Published: June 2020

Introducción: Las malformaciones congénitas del tracto digestivo constituyen un espectro variado de patologías, que incluyen: la aparición de atresias o estenosis del tubo digestivo, duplicaciones del tracto intestinal, mal posicionamiento de estructuras o deformidades anatómicas que pueden provocar alteraciones, tanto en el periodo neonatal como a lo largo de la infancia. La mayoría de las malformaciones digestivas se presentan únicas, aunque muchas de ellas asocian alteraciones en otros órganos o sistemas, o bien síndromes o alteraciones genéticas, que condicionan el pronóstico de la enfermedad del niño con malformación. Caso: Se trata de una paciente nacida a termino con diagnóstico de obstrucción intestinal, malrotación intestinal, bandas congénitas de ladd, atresia íleo terminal. Discusión: La morbilidad y mortalidad de los casos de obstrucción intestinal reportados en las series actuales generalmente es extremadamente baja y está determinada principalmente por la coexistencia de otras anomalías congénitas importantes (p. ej., cardíacas), retrasos en el diagnóstico y tratamiento o condiciones médicas coexistentes. Los tratamientos más nuevos y los desarrollos futuros pueden reducir la mortalidad residual en casos como el síndrome de intestino ultracorto. Conclusiones: las imágenes diagnósticas son de gran utilidad para su aproximación y manejo oportuno y la resección quirúrgica tanto endoscópica como abierta son el pilar fundamental en el tratamiento.
PHENOMENOLOGICAL ANALYSIS OF THE USING OF THE LOCAL WISDOM BASED ON THEMATIC LEARNING FILM IN STUDENTS OF PRIMARY EDUCATION AT UNIVERSITAS MURIA KUDUS
Authors: Oktavianti Ika , Ratnasari Yuni , Zuliana Eka , Agustian Murniati , Hasianna Tampubolon Lamtiur 
Published: June 2020

Purpose of Study: This study aims to examine, analyze, and describe the use of the local wisdom based on learning film in the students of primary education at Universitas Muria Kudus comprising the messages, perspectives of students, and the effects of local wisdom based learning film.
Methodology: This research used a qualitative research approach with a research participation pattern and phenomenological strategy. The main informant in this research was the students of the Primary Education Department at Universitas Muria Kudus who took the ethno-learning class. The data collection techniques used were observation, focus group discussion, interview, and documentation. The analysis of research data used the interactive-analysis model.
Main Findings: This study shows that students’ obtained knowledge regarding the process of local wisdom based on the thematic learning, which is implemented in the learning process, by using local wisdom and natural resources as a learning media, learning evaluation process, and the implementation of character education in the learning activity.
Implications: The local wisdom based learning film could be used as the material to develop the pedagogical and professional competence, to motivate students in developing local wisdom based learning as the theme of the thesis.
Novelty/Originality of this study: The effect of local wisdom based learning film was that students were able to design learning devices and implemented local wisdom based thematic learning in the class, causing the optimal result of ethno-learning lecturing, and improved the thesis of students which was concerned on local wisdom based learning.
MEASURING STUDENTS’ PROBLEM-SOLVING SKILLS ON DIRECT CURRENT CIRCUITS WITH MULTIPLE REPRESENTATIONS
Authors: Dewati Maria , Suparmi A. , Sunarno Widha , Sukarmin  , Cari C. 
Published: June 2020

Purpose of study: This study aims to measure the level of students' problem-solving skills, using assessment instruments in the form of multiple-choice tests based on the multiple representation approach on DC electrical circuits.
Methodology: This research is a quantitative descriptive involving 46 students of physics education. Students are asked to solve the problem of DC electrical circuits on 12 multiple choice questions with open reasons, involving verbal, mathematical, and picture representations. Data were analyzed by determining means and standard deviations.
Main findings: The results of the study showed that there were 3 levels of students' problem-solving skills, namely 7 (15%) students in the high category, 22 (48%) students in the medium category and 17 (37%) students in the low category.
Applications of this study: The implication of this research is to continuously develop assessment instruments based on multiple representations in the form of various types of tests, to help students improve their conceptual understanding, so students can solve physics problems correctly.
The novelty of this study: Researchers explain the right way to solve physics problems, 1) students are trained to focus on identifying problems, 2) students are accustomed to planning solutions using a clear approach, to build an understanding of concepts, 3) students are directed to solve problems accordingly with understanding the concepts they have built.
MULTIPLE DICTIONARY FOR SPARSE MODELING
Authors: Correia Rachel , D’mello Shonal , Dmonti Primeya , Figer Jerina 
Published: June 2020

Much of the progress made in image processing in the past decades can be attributed to better modeling of image content, and a wise deployment of these models in relevant applications. In this paper, we review the role of this recent model in image processing, its rationale, and models related to it. As it turns out, the field of image processing is one of the main beneficiaries from the recent progress made in the theory and practice of sparse and redundant representations. Sparse coding is a key principle that underlies wavelet representation of images. Sparse representation based classification has led to interesting image recognition results, while the dictionary used for sparse coding plays a key role in it. In general, the choice of a proper dictionary can be done using one of two ways: i) building asparsifying dictionary based on a mathematical model of the data, or ii) learning a dictionary to perform best on a training set.
Pathogenèse des Encéphalopathies Spongiformes Transmissibles : apports du modèle ovin
Authors: SCHELCHER F. , ANDREOLETTI O. , TABOURET G. , LACROUX C. , FOUCRAS G. , EYCHENNE F. , BERTHON P. , SARRADIN P. , LANTIER F. , ELSEN J.M. 
Published: June 2020

Parmi les Encéphalopathies Spongiformes Transmissibles (EST), la tremblante du mouton est un modèle d’infection naturelle, caractérisé par la diversité des souches d’agent de transmission, par un rôle majeur des facteurs génétiques de réceptivité/sensibilité et par une transmission interindividuelle fréquente. La voie de contamination naturelle semble être orale. Chez des ovins génétiquement sensibles (PrPVRQ/VRQ) (premiers symptômes observés vers 20 à 24 mois), la PrPsc a été détectée dans les plaques de Peyer iléales dès l’âge de 21 jours. L’ensemble des formations lymphoïdes secondaires est envahi entre l’âge de 3 et 6 mois. Dans les tissus lymphoïdes, la PrPsc s’accumule d’abord dans les cellules CD 68+ (cellules dendritiques ou macrophages) puis dans les cellules folliculaires dendritiques. A partir des plexus nerveux myentériques, la PrPsc gagnerait le système nerveux central par les nerfs sympathiques et parasympathiques. Les cellules de Schwann pourraient jouer un rôle majeur dans ce transfert. L’envahissement du névraxe débute vers 9 à 10 mois d’âge, dans le noyau dorsal du nerf vague et dans les segments médullaires T4–T9. A partir des organes lymphoïdes et/ou nerveux, la PrPsc contamine d’autres tissus en particulier placentaire et musculaire. Les modalités de contamination, sanguine versus nerveuse, restent hypothétiques. L’accumulation de PrPsc dans le trophoblaste placentaire de brebis infectées, est déterminée par le génotype PrP du foetus. Dans les muscles d’ovins en phase d’incubation ou en phase clinique, la PrPsc est détectable dans des structures particulières, les fuseaux neuromusculaires, mais à des concentrations environ 5000 fois inférieures à celles détectées dans l’obex d’ovins en phase clinique. Chez les ovins, ces résultats (nature des tissus atteints, cinétique) sont étroitement dépendants du génotype PrP de l’hôte et probablement de la souche d’EST. L’extension à d’autres modèles animaux ou humains doit donc être réalisée avec prudence.
Transferência de Tecnologia para Monitoramento Ambiental por Drone em Aterros Sanitários Regulados e Recursos Hídricos no Vale do Itajaí – SC
Authors: Silva Péricles Rocha , Ribeiro Eduardo , Serpe Bernadete , Matallana Gloria , Meira Eduardo , Mattedi Marcos , Gaia Cintia , Spiess Maiko , Ludwing Leandro , Castro Cloves , Guimarães Philippe , Martins Amarildo 
Published: June 2020

O relato de experiência é sobre uma ação de inovação e transferência de tecnologia para o municipio de Pomerode (Secretaria Municipal de Educação) e algumas escolas de Blumenau. A ação foi uma atividade de inovaçãp pedagógica a partir da apropriação da tecnologia desenvolvida por uma patente registrrada entre o Instituto Federal Catarinense e a Fundação Universidade Regional de Blumenau. A experiência a ser relatada pode ser exemplificada como um exemplo de ação que deve ser desenvolvida em uma política institucional de inovação, gestão de propriedade intelectual .
Do the human gut metagenomic species possess the minimal set of core functionalities necessary for life?
Authors: Soverini Matteo , Rampelli Simone , Turroni Silvia , Brigidi Patrizia , Biagi Elena , Candela Marco 
Published: June 2020

Abstract
Background: Advances in bioinformatics recently allowed for the recovery of ‘metagenomes assembled genomes’ from human microbiome studies carried on with shotgun sequencing techniques. Such approach is used as a mean to discover new unclassified metagenomic species, putative biological entities having distinct metabolic traits. Results: In the present analysis we compare 400 genomes from isolates available on NCBI database and 10,000 human gut metagenomic species, screening all of them for the presence of a minimal set of core functionalities necessary, but not sufficient, for life. As a result, the metagenome-assembled genomes resulted systematically depleted in genes encoding for essential functions apparently needed to support autonomous bacterial life.Conclusions: The relevant degree of lacking core functionalities that we observed in metagenome-assembled genomes raises some concerns about the effective completeness of metagenome-assembled genomes, suggesting caution in extrapolating biological information about their metabolic propensity and ecology in a complex environment like the human gastrointestinal tract.
Capturing the complexity of healthcare for people with Down syndrome in quality indicators - a Delphi study involving healthcare professionals and patient organisations
Authors: Mareeuw Francine A. van den Driessen , Coppus Antonia M.W. , Delnoij Diana M.J. , de Vries Esther 
Published: June 2020

Abstract
Background: Insight into quality of healthcare for people with Down Syndrome (DS) is limited. Quality indicators (QIs) can provide this insight. This study aims to find consensus among participants regarding QIs for healthcare for people with DS.Methods: We conducted a four-round Delphi study, in which 33 healthcare professionals involved in healthcare for people with DS and two patient organisations’ representatives in the Netherlands participated. Median and 75-percentiles were used to determine consensus among the answers on 5-point Likert-scales. In each round, participants received an overview of participants’ answers from the previous round.Results: Participants agreed (consensus was achieved) that a QI-set should provide insight into available healthcare, enable healthcare improvements, and cover a large diversity of quality domains and healthcare disciplines. However, the number of QIs in the set should be limited in order to prevent registration burden. Participants were concerned that QIs would make quality information about individual healthcare professionals publicly available, which would induce judgement of healthcare professionals and harm quality, instead of improving it. Conclusions: We unravelled the complexity of capturing healthcare for people with DS in a QI-set. Patients’ rights to relevant information have to be carefully balanced against providers’ entitlement to a safe environment in which they can learn and improve. A QI-set should be tailored to different healthcare disciplines and information systems, and measurement instruments should be suitable for collecting information from people with DS. Results from this study and two preceding studies, will form the basis for the further development of a QI-set.
Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: A retrospective cohort study
Authors: Choi Hayoung , Ko Yousang , Lee Chang Youl 
Published: June 2020

Abstract
Background: Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a challenge for clinicians. The aim of this study was to determine whether pro-cathepsin D can serve as a novel biomarker to discriminate between MPE and benign pleural effusion (BPE).Methods: This study included 81 consecutive patients with exudative pleural effusions who had underwent thoracentesis or pleural biopsy. Pleural fluid and serum were collected as a standard procedure for all individuals at the same time. The level of pro-cathepsin D was measured by the sandwich enzyme-linked immunosorbent assay method.Results: Though there were no significant differences in plasma pro-cathepsin D between the two groups, the level of pleural fluid pro-cathepsin D was signiﬁcantly higher in the MPE group than the BPE group (0.651 versus 0.590 pg/mL, P = 0.034). The discriminative power of pleural fluid pro-cathepsin D for diagnosing MPE was moderate, with 71% sensitivity and 73% specificity at a pro-cathepsin D cut-off ≥ 0.651 pg/mL (area under the curve: 0.698). Positive and negative predictive values for MPE were 39% and 92%, respectively, with pro-cathepsin D cut-off value (> 0.651 pg/mL). Conclusions: The level of pleural fluid pro-cathepsin D was found to be significantly higher in MPE than in BPE. Although results of this study could not support the sole use of pleural fluid pro-cathepsin D to diagnose MPE, pleural fluid pro-cathepsin D can be added to pre-existing diagnostic methods for ruling-in or ruling-out MPE.