bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart rate variability predicts 8-year risk of cardiovascular disease: The Taiwan Bus Driver Cohort Study (TBDCS)
Authors: Wang Ying-Chuan , Wang Chung-Ching , Chen Bae-Ling , Wu Wei-Te 
Published: June 2020

Abstract
Background: Characteristics of professional drivers like irregular work shifts, long hours of driving, sedentary restricted postures, long-term sleep deficiency, increase the probability of developing cardiovascular disease (CVD). Therefore, early monitoring CVD risk is important to device preventive measures in the workplace.Objective: This cohort study used to evaluate the effectiveness of noninvasive heart rate variability (HRV) analysis to assess the 8-year risk of CVD events.Methods: Personal and working characteristics were collected before biochemistry examinations and 5-min HRV tests from Taiwan Bus Driver Cohort Study (TBDCS) in 2005. Then, this cohort was linked to Taiwan’s National Health Insurance Research Database (NHIRD) to obtain subjects’ medical information. This study eventually identified 161 drivers with CVD and 627 without from 2005 to 2012. Cox proportional hazards model were performed to estimate the hazard ratio for CVD.Results: Subjects with overall CVD had lower the standard deviation of NN intervals (SDNN) than their counterparts. Even after adjusting for risk factors, SDNN index have a strong association with overall CVD. Using median split for SDNN, hazard ratio of overall CVD was 1.83 (95% CI 1.10–3.04) in model 1 and 1.87 (95% CI 1.11–3.13) in model 2. Furthermore, Low frequency (LF) index associated with risk of overall CVD in the continuous approach. For hypertensive disease, the SDNN index was associated with increased risks in both the continuous and dichotomized approaches. When Root Mean Square of the Successive Differences (RMSSD), high frequency (HF), and LF as a continuous variable, the significant association with hypertensive disease were observed.Conclusions: This cohort study suggests that SDNN and LF levels are useful for predicting 8-year CVD risk, especially for hypertensive disease. Further research is required to determine preventive measures for modifying HRV dysfunction as well as to investigate whether these interventions could reduce CVD risk in professional drivers.
Infra-Acetabular Screw Exited Between Ischial Tuberosity and Ischial Spine is more Suitable for Asian Population: A 3D Morphometric Study
Authors: Liu Fei , Feng Xiaoreng , Xiao Yang , Xiang Jie , Chen Keyu , Deng Yihang , Lyu Jiaxin , Chen Bin 
Published: June 2020

Abstract
Background Recently, the infra-acetabular screw was proposed for acetabular fractures as a part of a periacetabular fixation frame. Biomechanical studies showed that an additional infra-acetabular screw placement can enhance the fixation strength of acetabular fracture internal fixation. At present, the reported exit point of the infra-acetabular screw was all located at the ischial tuberosity. However, through great experience in placing the infra-acetabular screw, we realized that when the exit point was located between the ischial tuberosity and the ischial spine, the placement of a 3.5 mm infra-acetabular screw is easier in some patients. Methods This study used axial perspective based on 3D models to study the anatomical parameters of the two different infra-acetabular screw corridors. Placed the largest diameter virtual screw in the two different screw corridors. The data obtained in this study present the maximum diameters, length, directions, and distances between the entry point and the center of IPE. Results In 65.31% males and 40.54% females, a Screw I corridor with a diameter of at least 5 mm was found, while in Screw II it was 77.55% in males and 62.16% in females. Compared with screw I, the length of screw II is reduced, the angle with the coronal plane is significantly reduced, and the angle with the transverse plane is significantly increased.Conclusions For East Asians, changing the exit point of the infra-acetabular screw can increase the scope of use of the infra-acetabular screw, especially for females.
Ceramic Bricks Containing Ni Ions From Contaminated Biomass Used As Adsorbent
Authors: Simón Daiana , Quaranta Nancy , Gass Sebastián , Procaccini Raúl , Cristóbal Adrián 
Published: June 2020

Abstract
This article shows how pine sawdust residues can be used to adsorb nickel ions from synthetic solutions and then to produce porous bricks for civil construction using a mixture of natural clay and biomass containing the adsorbed metals. The adsorption process was carried out with NiCl2 solutions in contact with pine sawdust for a fixed stirring time of 24 hours. The mixture was filtered and the filtrate was analysed. The highest efficiency adsorbate / adsorbent ratio was 1 mol L− 1 of NiCl2 solution and 20 g L− 1 of pine sawdust. This was the contaminated biomass sample used in the manufacture of the bricks. This paper analyses the properties of the bricks achieved and compares them with bricks without added biomass, porous bricks containing zinc and commercial bricks. The obtained values ​​of apD: bulk density, aspW: apparent specific weight, apP: apparent porosity, H2O Abs: water absorption, apV: apparent volume, LOI: weight loss on ignition, σstr: compression fracture stress, MOR: flexural modulus of rupture and RE: retention efficiency, indicate that the bricks obtained are suitable for use in civil construction.
A survey of psychological responses during the Coronavirus Disease 2019 (COVID-19) epidemic among Chinese police officers in Wuhu
Authors: Yuan Lili , Zhu Lele , Chen Fangfang , Cheng Qian , Yang Qian , Zhou Zhiming , Zhu Yujuan , Wu Yigao , Zhou Yong , Zha Xiaojuan 
Published: June 2020

Abstract
Background

The outbreak of Coronavirus Disease 2019 (COVID-19) has caused serious threats to people’s health and lives. The police officers are bravely fighting on the front lines of the epidemic. Our study is the first survey of psychological response in the police officers of China during the tumultuous time of the COVID − 19 outbreak.
Methods

A cross-sectional online questionnaire was conducted to the police officers from 5 districts (Yijiang, Sanshan, Jiujiang, jinghu and Jingkai) and 4 counties (Wuhu, Nanling,Fanchang and Wuwei) of Wuhu City through Wechat, and the data were collected between 10 and 26 March 2020. A total of 3561 questionnaires were received in the study, of which 3517 were considered valid. The questionnaires included the demographic information and psychological survey. The depression scale of the patient health questionnaire (PHQ-9) and generalized anxiety disorder 7-item scale (GAD-7) were employed to assess depression and anxiety, respectively.
Results

The mean depression score of the participants was 4.10 ± 4.87 (0 ~ 27). 12.17% of the police officers had moderate to severe depression. The mean anxiety score of the participants was 3.59 ± 4.228 (0 ~ 21). 8.79% the police officers had moderate to severe anxiety. The participants of senior high school or below and academy had lower depression and anxiety scores than these of bachelor or above, respectively. The police officers Unmarried had lower anxiety scores than married. The different location and police classification were associated with the different degree of depression and anxiety. The participants who did not take sleeping pills had lower depression and anxiety scores than those who took sleeping pills. The depression scores of the police officers were strongly correlated with their anxiety scores of the police officers.
Conclusion

The police officers have different levels of anxiety and depression during the COVID-19 epidemic in Wuhu. We should call for attention to the psychological response of police officers during the epidemic, and provide them with corresponding help and follow-up.
Evaluating the TubridgeTM Flow Diverter for Large Cavernous Carotid Artery Aneurysms
Authors: Jia Luqiong , Wang Jiejun , Zhang Longhui , Zhang Yunfeng , You Wei , Yang xinjian , Lv Ming 
Published: June 2020

Abstract
Background: The TubridgeTM flow diverter (TFD) was recently developed in China; however, its safety and efficacy in treating large cavernous carotid artery aneurysms (LCCAs) are unclear.Objective: To evaluate the safety and efficacy of the TFD in patients receiving TFDs to treat LCCAs (10–25 mm). Methods: Between June 2013 and May 2014, seven patients with LCCAs were enrolled in our study, and all seven patients underwent TFD implantation combined with coils.Results: Angiographic follow-up images were available for all seven patients at a median of 57.5 ± 16.7 (range, 6–69) months. Seven patients obtained favorable angiographic results defined as O’Kelly–Marotta Scale C and D. Clinical follow-up data were available for all seven patients at a median of 73.32 ± 3.6 (range, 66–78) months. No patients developed new neurological deficits. Six patients achieved a modified Rankin scale score of 0, and diplopia improved in the remaining patient.Conclusions: Results were excellent for the aneurysms treated with TFDs in our patients with LCCAs. TFDs are feasible for the treatment of LCCAs, but a multicenter, controlled clinical trial is needed to evaluate the long term safety and efficacy of the TFD to treat LCCAs.
Icariin Combined with Adipose-Derived Stem Cells Ameliorated Osteoporosis in Postmenopausal Rats
Authors: Sun Ying , Wang Dongbo , Tang Dao , Liu Yanjie , Xu Fei , Wang Zhengguang , Liu Ziqi 
Published: June 2020

Abstract
Purpose: Osteoporosis is a chronic metabolic disease, it has caused the high incidence of related fractures, which seriously affects the life quality of the patients, especially in early postmenopausal women. Methods: Rat osteoporosis model was induced by bilateral ovarian ablation. Sprague Dawley (SD) rats were randomly divided into five groups (n=9): sham group, model group, the icariin group, ADSCs group, icariin combined with ADSCs group. H&E staining was used to observe the pathological changes of femur. The expression of calcitonin receptor (CALCR) and cathepsin K (CTSK) were investigated by immunohistochemistry. The expression of osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) were measured by qRT-PCR, immunohistochemistry and western blot.Results: The results showed that icariin combined with ADSCs ameliorated osteoblast morphology and bone density. Icariin combined with ADSCs significantly attenuated the protein expression of CALCR and CTSK after ovariectomy. Moreover, the expressions of OPG mRNA and protein were increased (p < 0.05), while the expressions of RANKL mRNA and protein were decreased (p < 0.05) in osteoblasts.Conclusions: Icariin combined with ADSCs can effectively inhibit PMOP in rats. The mechanism may be achieved by up-regulated the ratio of OPG / RANKL.
Socially Connected during COVID-19: Online social connections mediate the relationship between loneliness and positive coping strategies
Authors: Moore Kathleen Anne , March Evita 
Published: June 2020

Abstract
The novel coronavirus, COVID-19, spend across the world in early 2020. Many countries imposed social isolation restrictions where people were confined to their homes unless their work was deemed an essential service or for short outings to obtain necessary food and household supplies. We hypothesised that a lack of face-to-face social interactions would contribute to feelings of loneliness and reductions in healthy coping behaviours, and predicted that use of media connections to liaise with others would mediate this negative relationship. Two hundred and ten participants responded to an online survey with useable data available from 181 persons (127 females) (age M = 37.82 years, SD = 13.24). Data from a series of scales designed for this study revealed moderate levels of loneliness that directly predicted reduced engagement in healthy coping behaviours. This direct relationship was mediated by the use of media connections to liaise with others during the period of social isolation. Exploratory Factor Analyses indicated media connections included two factors: Communication (e.g., phoning, texting) and social media (e.g., Facebook, Instagram). While the data were not representative of the wider population in terms of education and gender spread, the diversity of ages is a compensating factor. Suggestions for maintaining health and the importance of support during times of trauma, to wit, the COVID-19 pandemic, are discussed.
Treatment Intensity Stratification in COVID-19 by Fully Automated Analysis of Pulmonary and Cardiovascular Metrics on Initial Chest CT using Deep Learning
Authors: Weikert Thomas , Rapaka Saikiran , Grbic Sasa , Re Thomas , Chaganti Shikha , Winkel David , Anastasopoulos Constantinos , Bremerich Jens , Twerenbold Raphael , Sommer Gregor , Comaniciu Dorin , Sauter Alexander W. 
Published: June 2020

Abstract
ObjectivesTo predict ultimate treatment intensity of COVID-19 patients using pulmonary and cardiovascular metrics fully automatically extracted from initial chest CTs.Methods All patients tested positive for SARS-CoV-2 by RT-PCR at our emergency department between March 25 and April 14, 2020 were identified (n=391). For those patients, all initial chest CTs were analyzed (n=85). Multiple pulmonary and cardiovascular metrics were extracted using deep convolutional neural networks. Three clinical treatment intensity groups were defined according to the most intensive treatment of a patient, determined six weeks later: Group 1 (outpatient), group 2 (general ward), and group 3 (intensive care unit; ICU). Univariate analyses were performed to analyze differences between groups. Subsequently, multiple metrics were combined in two binary logistic regression analyses and resulting prediction probabilities used to classify whether a patient needed hospitalization or ICU care. For analysis of discriminatory power, ROC curves were plotted and areas-under-the-curves (AUCs) calculated.ResultsThe mean interval between presentation at the emergency department and the chest CT was 1.4 days. Among others, mean percentage of lung volume affected by opacities (PO) and mean total pericardial volume (TPV) increased statistically significantly with higher treatment intensity [from group 1 to 3, standard deviation in brackets: PO: 0.8%(1.5)–11.6%(13.1)–31.6%(20.1); TPV: 733.4ml(231.7)–866.2ml(211.2)–925.7ml(125.5); both: p<0.001]. AUCs were 0.85 (ICU vs. no ICU) and 0.94 (hospitalization vs. no hospitalization).Conclusions Metrics fully automatically extracted from initial chest CTs increase with treatment intensity of COVID-19 patients. This information can be exploited to prospectively manage allocation of healthcare resources.
Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study
Authors: Zhou Li , Mo Xiaoxing , Wang Qiang , Liu Hongjie , Liu Yang , Luo Qinchun , Yin Jiawei , Peng Xiaobo , Huang Yue , Li Xiaoqin , Shan Zhilei , Liu Guohong , Xia Chao , Cheng Jinquan , Yang Wei , Sun Taoping , Liu Liegang 
Published: June 2020

Abstract
Background: Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated the association between whole-grain intake and MetS risk when using objective biomarkers of whole-grain intake. The aim of this study was to examine the association between plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population.Methods: A case-control study of 667 MetS cases and 667 matched controls was conducted based on baseline data of the Tongji-Ezhou Cohort study. Plasma DHPPA concentrations were assessed by high-performance liquid chromatography-tandem mass spectrometry. MetS was determined using definition of the Joint Interim Statement.Results: Plasma DHPPA was inversely associated with MetS risk. After adjustment for age, sex, body mass index, smoking status, alcohol drinking status, physical activity and education level, the odds ratios (ORs) for MetS across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.86 (0.58-1.26), 0.77 (0.52-1.15), and 0.59 (0.39-0.89), respectively. The inverse relation between plasma DHPPA and MetS persisted in stratified analyses according to confounding factors. In addition, the cubic spline analysis revealed a potential nonlinear association between plasma DHPPA and MetS, with a steep reduction in the risk at the lower range of plasma DHPPA concentration.Conclusions: Our study revealed that higher plasma DHPPA concentrations were associated with lower odds of MetS. Our findings provided further evidence to support health benefits of whole grain consumption.
Effect of Educational Progressive Web Application on Patient’s Oral and Denture Knowledge and Hygiene: A Randomised Controlled Trial
Authors: Ng Jade Yi Ming , Lim Tong Wah , Tarib Natasya , Ho Ting Khee 
Published: June 2020

Abstract
Background: Patient dental education is crucial for the prevention of oral diseases. Effective conveyance of post-denture delivery instructions is beneficial for promoting good oral and denture hygiene. This study aimed to evaluate the effect of a novel progressive web application (PWA) on the patient’s oral and denture knowledge and hygiene. The patient’s acceptance of this new educational approach was also assessed.Methods: A parallel randomised controlled trial was conducted at the Faculty of Dentistry, Universiti Kebangsaan Malaysia. A total of 52 cobalt–chromium removable partial denture wearers aged 25–75 years were randomised into two groups. The participants in the PWA group were educated using PWA, whereas those in the control group were educated verbally, accompanied by a practical demonstration of hygienic procedures. A questionnaire was provided to evaluate the changes in the participants’ knowledge score at baseline, immediately after education and at 3 months after education. A blinded single examiner conducted the clinical assessment of plaque index (PI), gingival index (GI) and denture plaque (DP) scores at baseline (D0) and at 1 month (D30) and 3 months after education (D90). The patients’ acceptance of PWA was explored through usage logs and a feedback form. Data were analysed using two-way mixed ANOVA, Mann–Whitney U test and Friedman test.Results: A total of 49 participants were analysed. The PWA and control groups showed significant improvement in knowledge scores and oral and denture hygiene indices (p < 0.001) after education. The PWA group demonstrated lower PI, GI and DP scores than the control group at D30 and D90. However, only the GI was significantly lower (p = 0.008) at D90. In addition, 92% of the participants used PWA at least once after being introduced to it.Conclusions: PWA was effective in improving the patients’ oral and denture knowledge and hygiene. The participants also found it as a useful reference material for denture care. Thus, PWA is a viable option for providing post-denture delivery instructions.Trial registration: ClinicalTrials NCT04358172. Retrospectively registered on 21/04/2020. https://clinicaltrials.gov/ct2/show/NCT04358172
Vitamin D Variants Levels Exposed and Association With the Disease Severity in Bronchial Asthma
Authors: Al-Thagfan Sultan S , Ahmed Sameh , Emara Magdy M , Awadallah Mohamed Fawzi 
Published: June 2020

Abstract
Background: Several vitamin D variants may be involved in immunity modulation including; vitamin D2 (D2), vitamin D3 (D3), 25-hydroxyvitamin D3 (25(OH) D3) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). The objective of this study is to assess serum levels of vitamin D variants in bronchial asthma patients and their correlations with disease activity markers.Methods: 113 persons divided into two groups were enrolled in this study. The first group included 73 asthmatic patients (57 males and 16 females) and the second included 40 healthy adult (31 male and 9 female) as a control group. Vitamin D variants serum levels were assessed using ultra performance liquid chromatography (UPLC) with tandem mass system. Different disease activity markers were assessed and correlated with serum levels of vitamin D variants. These markers included forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC% , peak expiratory flow (PEF), forced expiratory flow25–75% (FEF25-75%), eosinophilic blood count, and total immunoglobulin E (IgE), Results: The study showed that asthmatic patients had significant lower serum levels of vitamin D variants in comparison with the healthy control group (p ≤ 0.001). Also, serum vitamin D variants levels were significantly decreased in uncontrolled asthmatic patients as compared with the partially controlled and controlled patients. The correlation values were higher for 25(OH) D3 and 1,25-(OH) 2D3 compared to D2 and D3. Negative correlations were seen for eosinophilic blood count, total IgE and ACT.Conclusion: Serum levels of all vitamin D variants were reduced in asthmatic patients with moderate to strong correlations to the disease severity. These results suggest that vitamin D deficiency or even insufficiency may play a role in disease severity.
Recognizing the Hidden: Strengthening the HIV Surveillance System among Key and Priority Populations in Mozambique
Authors: Baltazar Cynthia Semá , Boothe Makini , Langa Denise Chitsondzo , Sathane Isabel , Horth Roberta , Young Peter , Schaad Nick , Raymond Henry F 
Published: June 2020

Abstract
High quality, representative data from HIV surveillance systems that have country ownership and commitment are critical for guiding national HIV responses. This is especially true for key and priority populations given their disproportionate role in the transmission of the virus. Since 2011, the Mozambique Ministry of Health has conducted five Biobehavioral Surveillance Surveys among key and priority populations as part of the national HIV surveillance system. We describe the experience of strengthening the HIV surveillance system among those populations through the implementation of these surveys in Mozambique. We document the lessons learned and the impact on coordination and collaboration; workforce development and institutional capacity building; data use and dissemination; advocacy and policy impact; financial sustainability and community impact. Given that traditional surveillance methodologies from routine data often do not capture these hidden populations, it will be important to ensure that BBS surveys are an integral part of ongoing HIV surveillance activities in Mozambique.