bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timing of delivery in women with pre-pregnancy diabetes mellitus: a population-based study
Authors: Brown Meghan , Melamed Nir , Murray-Davis Beth , Hassan Haroon , Mawjee Karizma , Barrett Jon , McDonald Sarah D , Ray Joel G , Geary Michael , Berger Howard 
Published: December 2019

ObjectivesControversy exists about the timing of delivery of women with pre-pregnancy type 1 and 2 diabetes mellitus (PDM). This study aims to compare maternal and neonatal outcomes after induction of labor (IOL) at 38 weeks’ gestation versus expectant management from 39 weeks onward.Research design and methodsThis was a retrospective population-based cohort study using data from the Better Outcomes Registry and Network in Ontario Canada. Included were all women with PDM, who had a singleton hospital birth at ≥380/7weeks’ gestation from 2012 to 2017. Maternal and perinatal outcomes were compared between 937 pregnancies that underwent IOL at 380/7–386/7weeks (‘38-IOL group’) versus 1276 pregnancies expectantly managed resulting in a birth at ≥390/7weeks (‘39-Exp group’). The primary outcome was all-cause cesarean delivery. Multivariable modified Poisson regression was performed to generate adjusted relative risks (aRR) and 95% CIs, adjusted for parity, maternal age, pre-pregnancy body mass index and PDM type. Other outcomes included instrumental delivery, neonatal intensive care unit (NICU) admission, and newborn metabolic disturbances.ResultsCesarean delivery occurred in 269 women (28.7%) in the 38-IOL group versus 333 women (26.1%) in the 39-Exp group—aRR 1.07 (95% CI 0.94 to 1.22). The respective rates of instrumental delivery were 11.2% and 10.2% (aRR 1.25, 95% CI 0.98 to 1.61). NICU admission was more common in the 38-IOL group (27.6%) than in the 39-Exp group (16.8%) (aRR 1.61, 95% CI 1.36 to 1.90), as were jaundice requiring phototherapy (12.4% vs 6.2%) (aRR 1.93, 95% CI 1.46 to 2.57) and newborn hypoglycemia (27.3% vs 14.7%) (aRR 1.74, 95% CI 1.46 to 2.07).ConclusionIn pregnant women with PDM, IOL at 380/7–386/7weeks was not associated with a higher risk of cesarean delivery, compared with expectant management, but was associated with a higher risk of certain adverse neonatal outcomes.
Advancing child nutrition science in the scaling up nutrition era: a systematic scoping review of stunting research in Guatemala
Authors: Cordon Ana , Asturias Gabriela , De Vries Thomas , Rohloff Peter 
Published: December 2019

IntroductionEver since the 1960s, Guatemala has been a principle site for global academic research on child growth and nutrition. Nevertheless, Guatemala still has one of the highest rates of child stunting in the world. Since 2012, Guatemala has had a comprehensive national policy on stunting, calling for a renewed investment in innovative, multilevel nutrition interventions and implementation science. Our objective was to perform a systematic search and scoping review of the literature on stunting in Guatemala to identify gaps in research and opportunities for responding to this unique policy opportunity.MethodsWe conducted a systematic search and scoping review on stunting in Guatemala, searching the PubMed, Web of Science and PsycINFO databases. Eligible articles were of any design or format, published in English and Spanish from 2000 to 2018. Articles were thematically grouped by those published before (2000–2011) and after (2012–2018) the new national policy initiatives.ResultsWe identified a total of 1934 articles through database searches. After full-text review, 104 were included in the synthesis. The volume of published articles on stunting increased from a mean of 3.2 to 9.4 articles/year before and after 2012. There was a shift toward articles generating new data on priority populations, including rural indigenous Maya populations (34% vs 61%, χ2 test, p=0.01). However, the proportion of studies conducting implementation evaluations or testing new interventions was low and did not change significantly (34% vs 18%, χ2 test, p=0.07). Among 17 identified intervention studies, only 4 tested multilevel interventions, and there were no published interventions incorporating nutrition-sensitive interventions.ConclusionsA systematic search and scoping review of the literature on child stunting in Guatemala identified critical opportunities for new research in multilevel interventions, nutrition-sensitive interventions and implementation science.
“In that One the Ālif is Missing”: Eunuchs and the Politics of Masculinity in Early Colonial North India
Authors: Abbott Nicholas 
Published: December 2019

AbstractAlthough ostensibly gendered as men and frequently maintaining independent, patriarchal households, enslaved eunuchs (khwājasarās) in pre- and early colonial regimes in South Asia were often mocked for their supposed effeminacy, bodily difference, and pretensions to normative masculinity. In the Mughal successor state of Awadh (1722-1856), such mockery grew more pronounced in the wake of growing financial demands from the British East India Company and attempts by eunuchs to alienate property with wills and testamentary bequests. Through examples of verbal derision directed at eunuchs, this essay shows that not only did ideas of normative masculinity serve as a vehicle for Awadh’s rulers to defend their sovereign authority from colonial encroachment, but that notions of normative manhood continued to inform eunuchs’ own self-perception into the nineteenth century.
Decoding Telegram: Iranian Users and ‘Produsaging’ Discourses in Iran’s 2017 Presidential Election
Authors: Kermani Hossein 
Published: December 2019

Abstract
This paper investigates the most-viewed posts in Persian Telegram channels during the period surrounding Iran’s 2017 presidential election. Telegram has become the most popular social medium in Iran, and its channels have played a significant role in recent social and political events. Based on the produsage theory and user-generated content concept, this research identifies the popular content and produsagers on Persian Telegram channels. Moreover, this paper evaluates the potential of these most-viewed posts to support or challenge the dominant discourses in Iran. Using a combination of content and discourse analyses, results show that user-generated content on Telegram supports and reinforces dominant discourses relatively strongly, rather than challenging them. They also show that politics and entertainment were the most popular content on Telegram and confirm that Telegram is usually considered a good tool for receiving information and news.
Loan Waivers and Bank Credit: Reflections on the Evidence and the Way Forward
Authors: Narayanan Sudha , Mehrotra Nirupam 
Published: December 2019

Executive Summary In the past decade, farm loan waivers have become a policy instrument to alleviate the financial distress of farmers. Despite agreement on the theoretical rationale for such debt forgiveness and its deep contextual relevance, many fear that in the long run, loan waivers might vitiate the repayment culture in the farm sector and undermine the financial status of banks. At present, critiques of large-scale loan waivers rest on limited evidence. This article reviews and synthesizes existing research and available data on the implications of loan waivers, especially for the flow of credit to farmers from banks. On most of the issues, such as farmer well-being and repayment culture, there seems to be mixed evidence on the consequences of debt waivers. Credible evidence on macroeconomic implications is limited, mainly on account of methodological challenges. This article concludes that even if loan waivers are an inappropriate strategy to support farm incomes in sustainable ways, the wide-ranging negative impacts on the formal banking sector are perhaps overstated. A more fruitful approach would be to focus on whether loan waivers can be designed to reduce the possible negative consequences for the formal banking system as well as for macroeconomic system. The article identifies three possible instruments—loan insurance products that will help banks cope with the consequences of large-scale defaults. Second, to explore the creation of a distress fund that will cushion state finances, should there be a need for debt waivers. Third, it would be useful to consider the operation of debt relief commissions to have an ongoing process for debt waivers.
Assessment of health-related quality of life among adults hospitalized with sickle cell disease vaso-occlusive crisis
Authors: Esham Kimberly S. , Rodday Angie Mae , Smith Hedy P. , Noubary Farzad , Weidner Ruth Ann , Buchsbaum Rachel J. , Parsons Susan K. 
Published: December 2019

AbstractSickle cell disease (SCD) is characterized by painful vaso-occlusive crises (VOCs). Self-reported pain intensity is often assessed with the Numeric Rating Scale (NRS), whereas newer patient-reported outcome measures (PROMs) assess multidimensional pain in SCD. We describe pain experiences among hospitalized adults with VOCs, using 2 PROMs: the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health and the Adult Sickle Cell Quality of Life Measurement System (ASCQ-Me). Adults with SCD hospitalized with VOCs at 2 academic centers in Boston, Massachusetts, from April 2016 to October 2017 were eligible. Participants completed the NRS and PROMs at admission and 7 days postdischarge. PROM scores were described and compared with population norms. Length of stay (LOS) and 30-day readmission rates were assessed. Forty-two (96%) of 44 eligible patients consented and completed admission assessments. Mean age was 30.2 years (standard deviation, 9.1), 60% were women, 76% were non-Hispanic black, and 64% had hemoglobin SS. Twenty-seven participants (64%) completed postdischarge assessments. Sixty percent had ≥4 VOCs in the last year. Nearly all PROMIS Global Health and ASCQ-Me scores were worse than population norms. NRS and PROMIS Global Physical Health scores improved after discharge, the latter driven principally by improvements in pain. Overall median LOS was 7 days, and 30-day readmission rate was 40.5%. Administration of PROMs among adults with SCD hospitalized for VOCs is feasible and demonstrates participants experienced recurrent, prolonged, and severe VOCs. PROMIS Global and ASCQ-Me scores indicated substantial suffering, and the striking 30-day readmission rate highlights the vulnerability of these patients.
Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria
Authors: Darling Thayer K. , Schenk Michael P. , Zhou Chengjing C. , Maloba Franklin M. , Mimche Patrice N. , Gibbins Jonathan M. , Jobe Shawn M. , Lamb Tracey J. 
Published: December 2019

Key PointsNbeal2 deficiency leads to significantly reduced lung and brain pathology and enhanced survival in a mouse model of malaria. Both antibody-dependent and antibody-independent platelet depletion in mice recapitulate the findings observed in Nbeal2−/− mice.
Obstacles open the door — Negative shocks can motivate individuals to focus on opportunities
Authors: Feng Jin , Zhou Wenxia , Li Shuoyu , Li Mengyi 
Published: December 2019

AbstractBy responding to the call for research on negative career shocks and future time perspective, this study regarded internal social capital as a tool of resource retention which shifts attention to negative career shocks’ positive effects. We test a moderated mediation model which illustrates the effect of negative career shocks on focus on opportunities—positive dimension of occupational future time perspective. Results revealed that internal social capital acts as the mediator between negative career shocks and focus on opportunities, and organizational embeddedness moderats the mediation effect. The relationship is stronger when individuals are highly embedded in organizations.
A multilevel and dynamic model of intragroup conflict and decision making: application of agent-based modeling
Authors: Wu Jiunyan , Sekiguchi Tomoki 
Published: December 2019

AbstractAlthough intragroup conflict has both multilevel and dynamic natures, less attention has been paid to establishing a holistic model of intragroup conflict that emerges across levels and unfolds over time. To address this research gap, we extend the multilevel view of intragroup conflict (Korsgaard et al. 2008) to develop a multilevel and dynamic model of intragroup conflict that explicitly includes (1) the role of time and (2) the feedback loop to encompass the dynamic aspect of intragroup conflict. We further instantiate the extended model in the context of team decision-making. To achieve this and systematically examine the complex relationships, we use agent-based modeling and simulation (ABMS). We directly investigate how two types of intragroup conflict—task and relationship conflict—interplay with cross-level antecedences, interrelate and develop over time, and affect team outcomes. This study adds to the intragroup conflict research by extending the field with multilevel and dynamic views.
Modelling travelers’ appraisal of ridepooling service characteristics with a discrete choice experiment
Authors: König Alexandra , Grippenkoven Jan 
Published: December 2019

Abstract
Background
Ridepooling services have been predicted a bright future since they promise a flexible and user-centered mobility service. However, there is a research gap in examining the travelers’ perception of ridepooling service characteristics since findings concerning fixed-scheduled public transport are hardly transferable.

Methods
In order to shed some light on the human factors of ridepooling services a Discrete Choice Experiment (N = 410) was performed to identify travelers’ preferences concerning ridepooling’s service features. The study thereby focusses on the effect of trip purpose on the appraisal of the service attributes. Based on a literature review and a focus group six attributes of the operational concept were determined: fare, walking distance to the pick-up point, time of booking in advance, shift of departure time, travel time and information.

Results
The results underline that all of the six attributes significantly affected choice behavior. The appraisal of the service characteristics differed depending on the presented trip purpose. The willingness to pay was calculated for each service characteristics. The results give guidance for the user-centered design and operation of ridepooling systems that meet the requirements of the prospective passengers and thus facilitate behavioral shifts towards more sustainable mobility systems.
Clinical risk prediction with random forests for survival, longitudinal, and multivariate (RF-SLAM) data analysis
Authors: Wongvibulsin Shannon , Wu Katherine C. , Zeger Scott L. 
Published: December 2019

Abstract
Background
Clinical research and medical practice can be advanced through the prediction of an individual’s health state, trajectory, and responses to treatments. However, the majority of current clinical risk prediction models are based on regression approaches or machine learning algorithms that are static, rather than dynamic. To benefit from the increasing emergence of large, heterogeneous data sets, such as electronic health records (EHRs), novel tools to support improved clinical decision making through methods for individual-level risk prediction that can handle multiple variables, their interactions, and time-varying values are necessary.

Methods
We introduce a novel dynamic approach to clinical risk prediction for survival, longitudinal, and multivariate (SLAM) outcomes, called random forest for SLAM data analysis (RF-SLAM). RF-SLAM is a continuous-time, random forest method for survival analysis that combines the strengths of existing statistical and machine learning methods to produce individualized Bayes estimates of piecewise-constant hazard rates. We also present a method-agnostic approach for time-varying evaluation of model performance.

Results
We derive and illustrate the method by predicting sudden cardiac arrest (SCA) in the Left Ventricular Structural (LV) Predictors of Sudden Cardiac Death (SCD) Registry. We demonstrate superior performance relative to standard random forest methods for survival data. We illustrate the importance of the number of preceding heart failure hospitalizations as a time-dependent predictor in SCA risk assessment.

Conclusions
RF-SLAM is a novel statistical and machine learning method that improves risk prediction by incorporating time-varying information and accommodating a large number of predictors, their interactions, and missing values. RF-SLAM is designed to easily extend to simultaneous predictions of multiple, possibly competing, events and/or repeated measurements of discrete or continuous variables over time.Trial registration: LV Structural Predictors of SCD Registry (clinicaltrials.gov, NCT01076660), retrospectively registered 25 February 2010
Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study
Authors: Godfrey Mary , Green John , Smith Jane , Cheater Francine , Inouye Sharon K. , Hurst Keith , Young John 
Published: December 2019

Abstract
Background
Delirium is a frequent complication of hospital admission among older people. Multicomponent interventions which can reduce incident delirium by ≈one-third are recommended by the National Institute of Health and Care Excellence. Currently, a standardised delirium prevention system of care suitable for adoption in the UK National Health Service does not exist. The Prevention of Delirium (POD) system of care is a theory informed, multicomponent intervention and systematic implementation process which includes a role for hospital volunteers. We report POD implementation and delivery processes in NHS hospital wards, as part of a feasibility study.

Methods
A comparative case study design and participatory, multi-method evaluation was performed with sequential six month preparatory and six month delivery stages. Six wards in five hospitals in Northern England were recruited. Methods included: facilitated workshops; observation of POD preparatory activities; qualitative interviews with staff; collection of ward organisational and patient profiles; and structured observation of staff workload.

Results
POD implementation and delivery was fully accomplished in four wards. On these wards, implementation strategies informed by Normalization Process Theory operated synergistically and cumulatively. An interactive staff training programme on delirium and practices that might prevent it among those at risk, facilitated purposeful POD engagement. Observation of practice juxtaposed to action on delirium preventive interventions created tension for change, legitimating new ways of organising work around it. Establishing systems, processes and documentation to make POD workable in the ward setting, enhanced staff ownership. ‘Negotiated experimentation’ to involve staff in creating, appraising and modifying systems and practices, helped integrate the POD care system in ward routines. Activating these change mechanisms required a particular form of leadership: pro-active ‘steer’, and senior ward ‘facilitator’ to extend ‘reach’ to the staff group. Organisational discontinuity (i.e. ward re-location and re-modelling) disrupted and extended POD implementation; staff shortages adversely affected staff capacity to invest in POD. Findings resulted in the development of ‘site readiness’ criteria without which implementation of this complex intervention was unlikely to occur.

Conclusions
POD implementation and delivery is feasible in NHS wards, but a necessary context for success is ‘site readiness.’
Supercapsular percutaneously-assisted total hip (SuperPath) versus posterolateral total hip arthroplasty in bilateral osteonecrosis of the femoral head: a pilot clinical trial
Authors: Meng Weikun , Huang Zhong , Wang Haoyang , Wang Duan , Luo Zeyu , Bai Yang , Gao Liang , Wang Guanglin , Zhou Zongke 
Published: December 2019

Abstract
Background
The supercapsular percutaneously-assisted total hip arthroplasty (SuperPath) was proposed to be minimally invasive and tissue sparing with possible superior postoperative outcomes to traditional approaches of total hip arthroplasty (THA). Here, we compared the short-term outcomes of staged THA with the SuperPath or through posterolateral approach (PLA) for bilateral osteonecrosis of the femoral head (ONFH).

Methods
Patients with bilateral late-stage ONFH were prospectively recruited from our department from March 2017 to March 2018. Staged bilateral THAs with one side SuperPath and the other side PLA were performed consecutively in the same patients with right and left hips alternating within approaches. The average time interval between the staged THAs was 3 months. Perioperative status (operation time, incision length, intraoperative blood loss, soft tissue damage, and length of hospital stay) and postoperative function (range of motion, pain, and hip function) were recorded and compared between the SuperPath and PLA approaches within 12-month postoperatively.

Results
Four male patients (age, 51.00 ± 4.54; BMI, 21.49 ± 1.73) with bilateral alcohol-induced ONFH (Ficat III/IV) were followed up over 12 months postoperatively. Compared with the PLA, the SuperPath yielded shorter incision length (7.62 vs. 11.12 cm), longer operation time (103.25 vs. 66.50 min), more blood loss (1108.50 vs. 843.50 ml), deficient abduction angle of the acetabular cup (38.75° vs. 44.50°), and inferior early-term hip function (Harris hip score, 72.50 vs. 83.25) at 12-month postoperatively. Soft tissue damage, length of hospital stay, postoperative pain, postoperative range of motion, and 12-month patient satisfaction were comparable between both approaches.

Conclusion
The SuperPath may be a minimally invasive technique but the present study shows less favorable short-term outcomes than PLA for total hip arthroplasty in osteonecrosis of the femoral head. More investigations are required to provide convincing favorable evidences of the SuperPath over other traditional THA approaches.

Trial registration information
The trial was retrospectively registered in https://www.researchregistry.com (No. Researchregistry4993) on July 04, 2019. The first participant was enrolled on March 13, 2017.
Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism
Authors: Hejlesen Jane , Underbjerg Line , Gjørup Hans , Sikjaer Tanja , Rejnmark Lars , Haubek Dorte 
Published: December 2019

AbstractBackgroundPseudohypoparathyroidism (PHP) is a rare and inherited disease caused by mutations in theGNAS-gene or upstream of the GNAS complex locus. It is characterized by end-organ resistance to PTH, resulting in hypocalcemia and hyperphosphatemia. We aimed to investigate the dental anomalies according to tooth types and the orthodontic characteristics of patients with PHP.MethodsUsing a cross-sectional design, 29 patients (23 females) with PHP, living in Denmark, were included, and their clinical intraoral photos and radiographs were examined.ResultsPulp calcification was found in 76% of the patients. Blunting of root apex was present in 55% and shortening of root in 48% of the examined patients. Blunting and shortening of roots were seen more often in premolars than in other tooth types (pboth < 0.01). Crowding of lower anterior teeth was frequently observed (36%) as well as diastema in the upper arch (25%), midline diastema (18%), and Class III malocclusion (11%).ConclusionIn the present study population, the teeth were frequently affected by pulp calcification and/or deviation of the root morphology. Blunting and shortening of root(s) were more often seen in premolars than in other tooth types. Class III malocclusion was relatively prevalent. It is important to pay attention to dental anomalies and occlusion in order to provide adequate care for patients with PHP.