bluuebunny/crossref_metadata_2025_split huggingface dataset:
Logical Predictivism
Authors: Martin Ben , Hjortland Ole 
Published: August 2020

AbstractMotivated by weaknesses with traditional accounts of logical epistemology, considerable attention has been paid recently to the view, known as anti-exceptionalism about logic (AEL), that the subject matter and epistemology of logic may not be so different from that of the recognised sciences. One of the most prevalent claims made by advocates of AEL is that theory choice within logic is significantly similar to that within the sciences. This connection with scientific methodology highlights a considerable challenge for the anti-exceptionalist, as two uncontentious claims about scientific theories are that they attempt toexplaina target phenomenon and (at least partially) prove their worth through successfulpredictions. Thus, if this methodological AEL is to be viable, the anti-exceptionalist will need a reasonable account of what phenomena logics are attempting to explain, how they can explain, and in what sense they can be said to issue predictions. This paper makes sense of the anti-exceptionalist proposal with a new account of logical theory choice,logical predictivism, according to which logics are engaged in both a process of prediction and explanation.
Perturbed Markov Chains with Damping Component
Authors: Silvestrov Dmitrii , Silvestrov Sergei , Abola Benard , Biganda Pitos Seleka , Engström Christopher , Mango John Magero , Kakuba Godwin 
Published: August 2020

AbstractThe paper is devoted to studies of regularly and singularly perturbed Markov chains with damping component. In such models, a matrix of transition probabilities is regularised by adding a special damping matrix multiplied by a small damping (perturbation) parameterε. We perform a detailed perturbation analysis for such Markov chains, particularly, give effective upper bounds for the rate of approximation for stationary distributions of unperturbed Markov chains by stationary distributions of perturbed Markov chains with regularised matrices of transition probabilities, asymptotic expansions for approximating stationary distributions with respect to damping parameter, explicit coupling type upper bounds for the rate of convergence in ergodic theorems forn-step transition probabilities, as well as ergodic theorems in triangular array mode.
Association between extreme heat and hospital admissions for cataract patients in Hefei, China
Authors: Xie Jingui , Zhu Yongjian , Fan Yiming , Xie Linbo , Xie Ruijin , Huang Fengming , Cao Liqing 
Published: August 2020

AbstractCataract is the first cause of blindness and the major cause of visual impairment worldwide. Under conditions of global warming, researchers have begun to give attention to the influence of increasing temperature on cataract patients. Our paper aimed to investigate the association between extreme heat and hospital admissions for cataract in Hefei, China. Based on data from the New Rural Cooperative Medical System and National Meteorological Information Center, we used a generalized additive model and a distributed lag nonlinear model to examine the relationship between extreme heat and hospitalizations for cataract, with consideration of cumulative and lagged effects. When current mean temperature was above 28 °C, each 1 °C rise was associated with a 4% decrease in the number of cataract admissions (RR = 0.96, 95% CI = 0.94–0.98). The cumulative relative risk over 11 days of lag was the lowest, which indicated that every 1 °C increase in mean temperature above 28 °C was associated with a 19% decrease in the number of hospital admissions for cataract (RR = 0.81, 95% CI = 0.75–0.88). In subgroup analyses, the negative association between extreme heat and hospital admissions for cataract was stronger among patients who were not admitted to provincial-level hospitals. In conclusion, this paper found that extreme heat was negatively associated with cataract hospitalizations in Hefei, providing useful information for hospitals and policymakers.
Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system
Authors: Wang Xiaohui , Wu Zhiqiang , Qiu Wei , Chen Ping , Xu Xiang , Han Weidong 
Published: August 2020

AbstractChimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.
Microfiltration results in the loss of analytes and affects the in vitro genotoxicity of a complex mixture of Alternaria toxins
Authors: Aichinger Georg , Živná Natálie , Varga Elisabeth , Crudo Francesco , Warth Benedikt , Marko Doris 
Published: August 2020

AbstractAlternaria molds produce a variety of chemically diverse secondary metabolites with potentially adverse effects on human health. However, data on occurrence in food and human exposure is inconsistent for some of these mycotoxins. Membrane filtration is a frequent step in many sample preparation procedures for LC-MS-based methods analyzing food contaminants. Yet, little is known about the possibility of adsorptive phenomena that might result in analyte losses. Thus, we treated a complex extract of Alternaria toxins with several types of syringe filters and unraveled the impact on its chemical composition by LC-MS/MS. We observed significant, and in some cases complete, losses of compounds due to filtration. Particularly, two key Alternaria toxins, alternariol (AOH) and its monomethyl ether (AME), were heavily affected. As a comparison with published food surveys indicating a correlation of the type of filtration used with lower incidence reports in food, our results point at a possible underestimation of AME in past exposure assessment. Also, perylene quinones were greatly affected by filtration, underlining the importance to take this into consideration during analytical method development. Furthermore, we applied the comet assay in HT-29 cells to elucidate the impact of filtration on the genotoxicity of the extract. We observed strong coincidences with the loss of epoxide-carrying metabolites and also an intriguing induction of oxidative DNA damage by yet toxicologically uncharacterized Alternaria toxins. In conclusion, we highlight potential issues with sample filtration and call for a critical re-evaluation of previous food occurrence data in the light of the results at hand.
Vibration analysis of simultaneous drilling and reaming BHA
Authors: Al Dushaishi Mohammed F. , Stutts Daniel S. 
Published: August 2020

AbstractThe drillstring used in the oil and gas exploration is a complex structure due to the different forces acting on it. One of the primary sources of drillstring vibrations is the cutting forces caused by the drill bit contact with the rock formation. In some drilling applications, such as hole enlargement and underreaming, the source of the cutting action originates from the drill bit as well as the reamer which increases the dynamic complexity of the drillstring. This paper’s objective is to investigate the torsional vibration behaviors of the bottom hole assembly (BHA) under simultaneous drilling and reaming. More specifically, it addresses the effect of the reamer interaction with the wellbore during drilling operations on the overall torsional vibrations of the BHA. The BHA was modeled as a torsional shaft subjected to a localized external force due to the reamer cutting action, and a point load external force due to the drill bit interaction with the formation. The equation of motion was obtained using Hamilton’s principle, and modal expansion was used to solve the equation of motion. The results showed that the location of the reamer within the BHA plays an important role in vibrations response. It was found that vibration modes that exhibit symmetry within the reamer location show a negligible effect on the overall BHA torsional response. Reamers with aggressive cutters cause higher vibration response when compared with a drill bit with the same cutter aggressiveness. The simplified model reveals the significance of properly matching the drill bit and the reamer to reduce the overall BHA torsional vibrations.
The Nomination of International Judges by ‘the Enlightened Few’: A Comment on the Royal Decree of 23 January 2020 Concerning the Establishment of a Dutch National Group at the Permanent Court of Arbitration
Authors: Jorritsma Remy 
Published: August 2020

AbstractOn 23 January 2020, the Government of the Netherlands adopted a Royal Decree concerning the Establishment of a Dutch National Group at the Permanent Court of Arbitration. The Decree aims to provide fairness, transparency and consistency in terms of the composition of the national group and its function of nominating candidates for election to international courts. This contribution puts the Dutch national group in context in the relevant international legal framework, analyses the specifics of the Decree and critically evaluates its strengths and weaknesses. It will be argued that while the Decree offers a number of welcome procedural specifications and innovations, it contains elements that deserve refinement and improvement in order to prevent that the Dutch national group acts (or is perceived to act) as a rubber stamp institution that simply carries out the will of the Government when making nominations for the international judiciary.
Aircraft sequencing and scheduling in TMAs under wind direction uncertainties
Authors: Cecen R.K. , Cetek C. , Kaya O. 
Published: August 2020

ABSTRACTAircraft sequencing and scheduling within terminal airspaces has become more complicated due to increased air traffic demand and airspace complexity. A stochastic mixed-integer linear programming model is proposed to handle aircraft sequencing and scheduling problems using the simulated annealing algorithm. The proposed model allows for proper aircraft sequencing considering wind direction uncertainties, which are critical in the decision-making process. The proposed model aims to minimise total aircraft delay for a runway airport serving mixed operations. To test the stochastic model, an appropriate number of scenarios were generated for different air traffic demand rates. The results indicate that the stochastic model reduces the total aircraft delay considerably when compared with the deterministic approach.
Analyses of criticality for multiple-site delaminations in the flap spar of Finnish F/A-18 aircraft
Authors: Jokinen J. , Kanerva M. , Wallin M. , Saarela O. 
Published: August 2020

AbstractMetal-composite airframes will suffer various defects during their lifetime. One category of defects is composite laminate delamination. This study evaluates the criticality of delaminations existing around adjacent fastener holes in the carbon-fibre-reinforced plastic spar web of the F/A-18 aircraft’s trailing-edge flap. The evaluation is based on experiments and analyses. First, an intensive experimental program for determining necessary material values of F/A-18 is described. Multiple delaminations of the flap spar web are then modelled by varying the set of delaminated hole edges and the interface of delamination. The interaction of defects at the start of delamination propagation is studied via the developed interaction parameter. The results suggest that the interaction parameter can show significant differences in the interaction per delamination case and that the interface of delamination is an important variable. Finally, operator-dependent control parameters are studied, and it is found that the criticality of a delamination case is merely dependent on true material parameters.
Optimisation of interval management – speed planning using SMPSO
Authors: Riedel T. , Takahashi M. , Itoh E. 
Published: August 2020

ABSTRACTRecent research on Flight-deck Interval Management (FIM), a modern technology for increasing safety and improving airspace and runway utilisation through self-spacing, has led to the development of a new rule-based logic for FIM, namely Interval Management – Speed Planning (IM-SP). In an initial benchmark study, IM-SP showed good spacing performance with a significant reduction in speed commands, a major area of concern with previous FIM logics, resulting in a lower burden on the flight crew during FIM operation. Nevertheless, there remains scope for improvement in other aspects, such as fuel burn. In this study, the internal cost function of IM-SP is further analysed and optimised using speed-constrained multi-objective particle swarm optimisation to improve the performance of IM-SP under the multiple objectives of FIM. The optimisation renders new settings that address the problem areas, improve the speed commands and enhance the overall quality of IM-SP. Two distinctive solutions, viz. a spacing performance optimised setting and a fuel burn optimised setting, are further analysed and discussed, and directions for follow-up research are explored.
The Problem of Unwelcome Epistemic Company
Authors: Blanchard Joshua 
Published: August 2020

AbstractMany of us are unmoved when it is objected that some morally or intellectually suspect source agrees with our belief. While we may tend to find this kind of guilt by epistemic association unproblematic, I argue that this tendency is a mistake. We sometimes face what I call the problem of unwelcome epistemic company. This is the problem of encountering agreement about the content of your belief from a source whose faults give you reason to worry about the belief's truth, normative status, etiology, or implications. On the basis of an array of cases, I elaborate four distinct kinds of problems that unwelcome epistemic company poses. Two of these are distinctly epistemic, and two are moral. I canvass possible responses, ranging from stubbornness to an epistemic prudishness that avoids unwelcome company at all costs. Finally, I offer preliminary lessons of the problem and distinguish it from the problem of peer disagreement.
Antimicrobial use for asymptomatic bacteriuria—First, do no harm
Authors: Shpunt Yana , Estrin Inna , Levi Yossef , Saadon Hodaya , Ben-Yossef Galit , Goldshtein Lili , Klafter Dan , Zilberman-Itskovich Shani , Ben-David Debby , Katz David E. , Lazarovitch Tsillia , Zaidenstein Ronit , Marchaim Dror 
Published: August 2020

AbstractObjective:Administration of antimicrobials to patients with asymptomatic bacteriuria (ASB) is a common error that can lead to worse outcomes. However, controlled analyses quantifying the commonality and impact of this practice are lacking. We analyzed the independent predictors for antimicrobials misuse in ASB and quantified the impact of this practice on clinical outcomes.Design:Retrospective case-control and cohort analyses for calendar year 2017.Setting:Tertiary-care, university-affiliated medical center.Patients:The study included adult (>18 years) patients with positive urine culture. Pregnant women, renal transplant recipients, and patients who underwent urologic procedures were excluded.Methods:ASB was determined according to US Centers for Disease Control and Prevention (CDC) criteria. Multivariable logistic regression models were constructed to analyze predictors and outcomes associated with antimicrobial use for patients with ASB.Results:The study included 1,530 patient-unique positive urine cultures. Among these patients, 610 patients (40%) were determined to have ASB. Of the 696 isolates, 219 (36%) were multidrug-resistant organisms (MDROs). Also, 178 (29%) patients received antimicrobials specifically due to the ASB. Independent predictors for improper administration of antimicrobials were dependent functional status (adjusted odds ratio [aOR], 2.3; 95% CI, 1.4–3.6) and male sex (aOR, 2; 95% CI, 1.25–2.6). Use of antimicrobials was independently associated with re-hospitalizations (aOR, 1.7; 95% CI, 1.1–2.6) and later, acute Clostridioides difficile infections (CDI) in the following 90 days (aOR, 4.5; 95% CI, 2–10.6).Conclusions:ASB is a common condition, frequently resulting from an MDRO. Male sex and poor functional status were independent predictors for mistreatment, and this practice was independently associated with rehospitalizations and CDI in the following 90 days.
Active deformation and Plio-Pleistocene fluvial reorganization of the western Kura fold–thrust belt, Georgia: implications for the evolution of the Greater Caucasus Mountains
Authors: Sukhishvili Lasha , Forte Adam M. , Merebashvili Giorgi , Leonard Joel , Whipple Kelin X. , Javakhishvili Zurab , Heimsath Arjun , Godoladze Tea 
Published: August 2020

AbstractSince Plio-Pleistocene time, southward migration of shortening in the eastern part of the Greater Caucasus into the Kura foreland basin has progressively formed the Kura fold–thrust belt and Alazani piggyback basin, which separates the Kura fold–thrust belt from the Greater Caucasus. Previous work argued for an eastward propagation of the Kura fold–thrust belt, but this hypothesis was based on coarse geological maps and speculative ages for units within the Kura fold–thrust belt. Here we investigate the initiation of deformation within the Gombori range in the western Kura fold–thrust belt and evaluate this eastward propagation hypothesis. Sediments exposed in the Gombori range have a Greater Caucasus source, despite the modern drainage network in the NE Gombori range, which is dominated by NE-flowing rivers. Palaeocurrent analyses of the oldest and youngest syntectonic units indicate a switch happened between ~2.7 Ma and 1 Ma from dominantly SW-directed flow to palaeocurrents more similar to the modern drainage network. A single successful26Al–10Be burial date indicates the youngest syntectonic sediments are 1.0 ± 1.0 Ma, which, while not a precise age, is consistent with original mapping suggesting these sediments are of Akchagylian–Apsheronian (2.7–0.88 Ma) age. These results, along with recent updated dating of thrust initiation in the eastern Kura fold–thrust belt, suggest that deformation within the Kura fold–thrust belt initiated synchronously or nearly synchronously along-strike. We additionally use topographic analyses to show that the Gombori range continues to be a zone of active deformation.
A NOTE ON p-ADIC SIMPLICIAL VOLUMES
Authors: KIONKE STEFFEN , LÖH CLARA 
Published: August 2020

AbstractWe define and study generalizations of simplicial volume over arbitrary seminormed rings with a focus on p-adic simplicial volumes. We investigate the dependence on the prime and establish homology bounds in terms of p-adic simplicial volumes. As the main examples, we compute the weightless and p-adic simplicial volumes of surfaces. This is based on an alternative way to calculate classical simplicial volume of surfaces without hyperbolic straightening and shows that surfaces satisfy mod p and p-adic approximation of simplicial volume.
Do costs and benefits of children matter for religious people? Perceived consequences of parenthood and fertility intentions in Poland
Authors: Bein Christoph , Mynarska Monika , Gauthier Anne H. 
Published: August 2020

AbstractThe aim of this study was to examine the positive relationship between religiosity and fertility from the perspective of perceived consequences of parenthood. Previous studies in Germany have found that highly religious people ascribe higher benefits and lower costs to having children. Furthermore, the impact of costs and benefits on fertility is less pronounced among the highly religious. This study tested these mechanisms for fertility intentions and in the context of Poland – a country with a low fertility rate and high religiosity in comparison to other European countries. A sample of 4892 men and women of childbearing age from the second wave of the Polish version of the Generations and Gender Survey conducted in 2014/2015 was used. First, the extent to which perceived costs and benefits mediate the impact of religiosity on fertility intentions was analysed. Second, whether religiosity moderates the impact of perceived costs and benefits on fertility intentions was investigated. The results show that part of the positive effect of religiosity on fertility intentions can be explained by more-religious people seeing higher benefits of having children. Furthermore, but only in the case of women, religiosity moderates the impact of perceived costs on fertility intentions, suggesting that the effect of perceived costs decreases with increasing religiosity.
Lameness in dairy cows: farmer perceptions and automated detection technology
Authors: Dutton-Regester Kate J. , Barnes Tamsin S. , Wright John D. , Rabiee Ahmad R. 
Published: August 2020

AbstractThis Research Reflection provides an overview of three interrelated topics: (i) lameness in dairy cows, demonstrating the underpinning importance of the condition, (ii) dairy farmer detection, diagnosis and treatment of lameness and associated foot lesions as well as dairy farmer perceptions towards the condition and (iii) lameness detection technologies, and their potential application on farm to automate the detection of lameness in commercial dairy herds. The presented literature clearly demonstrates that lameness is a major health issue in dairy herds, compromising dairy cow welfare and productivity, and resulting in significant economic implications for dairy farmers. Despite this, dairy farmers fail to perceive lameness as a serious threat to their dairy business. This restricted perception of the importance of lameness may be a product of limited ability to detect lame cows. Many automated lameness detection technologies have been proposed to assist dairy farmers in managing their herds. However, limitations such as cost, performance and dairy farmer perception of the usefulness of these technologies, has lead to poor uptake. It can, therefore, be concluded that there is a need to more thoroughly evaluate the effectiveness of these technologies under on-farm conditions, potentially in the form of a demonstration farm network. This will allow generation of the necessary data required to show dairy farmers that these technologies are reliable and are economically rational for their dairy business.