bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of factors for decreased lung function in elderly patients with type 2 diabetes
Authors: Ishii Masaki , Yamaguchi Yasuhiro , Hamaya Hironobu , Ogawa Sumito , Imura Mitsuo , Akishita Masahiro 
Published: December 2019

AbstractChronic obstructive pulmonary disease (COPD) often accompanies type 2 diabetes mellitus (T2DM). However, background factors affecting these diseases in the elderly remain unclear. Eligible patients with T2DM were divided into two age groups—non-elderly (<65 years) and elderly (≥65 years); COPD, ratio of forced expiratory volume in one second to forced expiratory volume (FEV1/FVC ratio), and percent predicted forced expiratory volume in one second (FEV1% predicted) were examined, and factors related to reduced respiratory function according to age group were evaluated. In total, 371 patients with T2DM were analysed. COPD was found in 9 patients (5.3%) in the non-elderly group and 45 (22.5%) in the elderly group. In the elderly, male sex, low body mass index (BMI), insulin therapy, and high C-peptide immunoreactivity levels were factors related to COPD. In the non-elderly, age, female sex, high BMI were factors related to decreased FEV1% predicted. Female sex was factor related to decreased FEV1% predicted in both age groups. Low BMI was a factor related to reduced respiratory function in elderly patients and high BMI was a factor related to reduced respiratory function in non-elderly patients. Thus, BMI needs to be managed according to the age and general condition of T2DM patients.
Full three-dimensional Poynting vector flow analysis of great field-intensity enhancement in specifically sized spherical-particles
Authors: Yue Liyang , Yan Bing , Monks James N. , Dhama Rakesh , Jiang Chunlei , Minin Oleg V. , Minin Igor V. , Wang Zengbo 
Published: December 2019

AbstractThe Poynting vector plays a key role in electrodynamics as it is directly related to the power and the momentum carried by an electromagnetic wave. Based on the Lorenz-Mie theory, we report on the focusing effect of a spherical particle-lens by properly analysing the Poynting vector maps. Conventional two-dimensional (2D) maps showing Poynting vector magnitude and direction in a given plane cannot deliver information on three-dimensional (3D) directivity and vectorisation in key regions of singularities, such as vortexes and saddle points, due to poor expressiveness. In this article, an analytical 3D mapping technology is utilised to track the field-features passing through the singularities of the distribution of the Poynting vector in a spherically dielectric mesoscale particle-lens. We discovered that the spheres with the certain size parameters can stimulate extremely large field-intensity at singularities and then form two circular hotspots around the sphere poles. An astonishing large ‘heart-shape’ 3D Poynting vector circulation, which cannot be predicted by conventional 2D mapping analysis, is found to provide a great angular variation within an enormous range in these spheres. We anticipate that this effect will contribute to the field-enhancement phenomena, such as surface enhances Raman scattering, surface enhances absorption, super-resolution imaging and others.
Unique Luminescence of Hexagonal Dominant Colloidal Copper Indium Sulphide Quantum Dots in Dispersed Solutions
Authors: Shin Samuel Jaeho , Koo Ja-Jung , Lee Jin-Kyu , Chung Taek Dong 
Published: December 2019

AbstractLuminescent hexagonal dominant copper indium sulphide (h-dominant CIS) quantum dots (QDs) by precursor-injection of mixed metal-dialkyldithiocarbamate precursors. Owing to the different reactivity of the precursors, this method allowed the CIS QDs to grow while retaining the crystallinity of the hexagonal nucleus. The photoluminescence (PL) spectra exhibited dual emission (600–700 nm red emission and 700–800 nm NIR emission) resulting from the combined contributions of the hexagonal (wurtzite) h-CIS and tetragonal (chalcopyrite) t-CIS QDs, i.e. the NIR and red emissions were due to the h-CIS QDs and coexisting t-CIS QDs (weight ratio of h-CIS/t-CIS ~ 10), respectively. The PL intensities of the h-CIS as well as t-CIS QDs were enhanced by post-synthetic heat treatment; the t-CIS QDs were particularly sensitive to the heat treatment. By separating h-CIS and t-CIS successfully, it was demonstrated that this phenomenon was not affected by size and composition but by the donor-acceptor pair states and defect concentration originating from their crystal structure. The h-dominant CIS QDs in this work provide a new technique to control the optical property of Cu-In-S ternary NCs.
Transferred monolayer MoS2 onto GaN for heterostructure photoanode: Toward stable and efficient photoelectrochemical water splitting
Authors: Hassan Mostafa Afifi , Kim Min-Woo , Johar Muhammad Ali , Waseem Aadil , Kwon Min-Ki , Ryu Sang-Wan 
Published: December 2019

AbstractSolar-driven photoelectrochemical water splitting (PEC-WS) using semiconductor photoelectrodes is considered a promising solution for sustainable, renewable, clean, safe and alternative energy sources such as hydrogen. Here, we report the synthesis and characterization of a novel heterostructure MoS2/GaN to be used as a photoanode for PEC-WS. The heterostructure was synthesized by metal-organic chemical vapor deposition of single crystalline GaN onto a c-plane sapphire substrate, followed by the deposition of a visible light responding MoS2 monolayer (Eg = 1.9 eV) formed by a Mo-sulfurization technique. Our experimental results reveal that MoS2/GaN photoanode achieved efficient light harvesting with photocurrent density of 5.2 mA cm−2 at 0 V vs Ag/AgCl, which is 2.6 times higher than pristine GaN. Interestingly, MoS2/GaN exhibited a significantly enhanced applied-bias-photon-to-current conversion efficiency of 0.91%, whereas reference GaN yielded an efficiency of 0.32%. The superior PEC performance of the MoS2/GaN photoelectrode is mainly related to the enhanced light absorption due to excellent photocatalytic behavior of MoS2, which reduces charge transfer resistance between the semiconductor and electrolyte interface, and the improvement of charge separation and transport. This result gives a new perspective on the importance of MoS2 as a cocatalyst coated onto GaN to synthesize photoelectrodes for efficient solar energy conversion devices.
Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering
Authors: Haka Jaana , Niemi Merja H. , Mattila Pekka , Jänis Janne , Takkinen Kristiina , Rouvinen Juha 
Published: December 2019

AbstractThe use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and capacity to induce protective IgG antibodies binding effectively to the native allergen upon sensitization would be beneficial for safer AIT. In this study, hypoallergen variants of the major horse allergen Equ c 1 were designed by introducing one point mutation on the putative IgE epitope region and two mutations on the monomer-monomer interface of Equ c 1 dimer. The recombinant Equ c 1 wild type and the variants were produced and purified to homogeneity, characterized by size-exclusion ultra-high performance liquid chromatography and ultra-high resolution mass spectrometry. The IgE-binding profiles were analyzed by a competitive immunoassay and the biological activity by a histamine release assay using sera from horse allergic individuals. Two Equ c 1 variants, Triple 2 (V47K + V110E + F112K) and Triple 3 (E21Y + V110E + F112K) showed lower allergen-specific IgE-binding capacity and decreased capability to release histamine from basophils in vitro when using sera from six allergic individuals. Triple 3 showed higher reduction than Triple 2 in IgE-binding (5.5 fold) and in histamine release (15.7 fold) compared to wild type Equ c 1. Mutations designed on the putative IgE epitope region and monomer-monomer interface of Equ c 1 resulted in decreased dimerization, a lower IgE-binding capacity and a reduced triggering of an allergic response in vitro.
Mandibular advancement impairs swallowing ability more than head extension but less than mouth opening in the supine position
Authors: Hanamoto Hiroshi , Togawa Eriko , Maegawa Hiroharu , Yokoe Chizuko , Inoue Mika , Oyamaguchi Aiko , Kudo Chiho , Niwa Hitoshi 
Published: December 2019

AbstractMandibular advancement in the supine position may influence swallowing during dental treatment under intravenous sedation. This study investigated the influence of mandibular advancement in the supine position on swallowing ability, compared with head extension and mouth opening. The water swallowing test was performed in 13 healthy, awake, supine, adult subjects under four head and mandibular positions. An electromyogram of the suprahyoid muscles was recorded; the duration and peak amplitude were examined. A greater volume of water remained in the mouth during mouth opening and mandibular advancement relative to the neutral position; the volume in the mandibular advancement position was larger and smaller than that in the head extension position and during mouth opening, respectively. The duration of the electromyogram in the head extension position was longer than that in the mandibular advancement position, without differences in the amplitude. Thus, swallowing ability in the supine position was more impaired with mandibular advancement, relative to neutral and head extension positions, but less than that observed with mouth opening. Although unconfirmed by electromyogram, our findings suggest that head extension might improve airway patency by reducing the impairment of swallowing ability compared with mandibular advancement.
Mesolimbic dopamine D2 receptors and neural representations of subjective value
Authors: Castrellon Jaime J. , Young Jacob S. , Dang Linh C. , Cowan Ronald L. , Zald David H. , Samanez-Larkin Gregory R. 
Published: December 2019

AbstractThe process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18 F]fallypride. Region-of-interest analyses revealed that D2R availability in the ventral striatum was positively correlated with subjective value-related activity in the ventromedial prefrontal cortex and midbrain but not with choice behavior. Whole-brain analyses revealed a positive correlation between ventral striatum D2R availability and subjective value-related activity in the left inferior frontal gyrus and superior insula. These findings identify a link between a direct measure of mesolimbic dopamine function and subjective value representation in humans and suggest a mechanism by which individuals vary in neural representation of discounted subjective value.
Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers
Authors: Sroor Hoda M. , Hassan Ahmed M. , Zenz Geraldine , Valadez-Cosmes Paulina , Farzi Aitak , Holzer Peter , El-Sharif Amany , Gomaa Fatma Al-Zahraa M. , Kargl Julia , Reichmann Florian 
Published: December 2019

AbstractInflammatory bowel disease (IBD) patients frequently suffer from anxiety disorders and depression, indicating that altered gut-brain axis signalling during gastrointestinal inflammation is a risk factor for psychiatric disease. Microglia, immune cells of the brain, is thought to be involved in a number of mental disorders, but their role in IBD is largely unknown. In the current work, we investigated whether colitis induced by dextran sulphate sodium (DSS), a murine model of IBD, alters microglial phenotypes in the brain. We found that colitis caused a reduction of Iba-1 and CD68 immunoreactivity, microglial activation markers, in specific brain regions of the limbic system such as the medial prefrontal cortex (mPFC), while other areas remained unaffected. Flow cytometry showed an increase of monocyte-derived macrophages during colitis and gene expression analysis in the mPFC showed pronounced changes of microglial markers including cluster of differentiation 86 (CD86), tumour necrosis factor-α, nitric oxide synthase 2, CD206 and chitinase-like protein 3 consistent with both M1 and M2 activation. Taken together, these findings suggest that experimental colitis-induced inflammation is propagated to the brain altering microglial function.
Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice
Authors: Gil Carla Igual , Ost Mario , Kasch Juliane , Schumann Sara , Heider Sarah , Klaus Susanne 
Published: December 2019

AbstractPhysical activity is an important contributor to muscle adaptation and metabolic health. Growth differentiation factor 15 (GDF15) is established as cellular and nutritional stress-induced cytokine but its physiological role in response to active lifestyle or acute exercise is unknown. Here, we investigated the metabolic phenotype and circulating GDF15 levels in lean and obese male C57Bl/6J mice with long-term voluntary wheel running (VWR) intervention. Additionally, treadmill running capacity and exercise-induced muscle gene expression was examined in GDF15-ablated mice. Active lifestyle mimic via VWR improved treadmill running performance and, in obese mice, also metabolic phenotype. The post-exercise induction of skeletal muscle transcriptional stress markers was reduced by VWR. Skeletal muscle GDF15 gene expression was very low and only transiently increased post-exercise in sedentary but not in active mice. Plasma GDF15 levels were only marginally affected by chronic or acute exercise. In obese mice, VWR reduced GDF15 gene expression in different tissues but did not reverse elevated plasma GDF15. Genetic ablation of GDF15 had no effect on exercise performance but augmented the post exercise expression of transcriptional exercise stress markers (Atf3, Atf6, and Xbp1s) in skeletal muscle. We conclude that skeletal muscle does not contribute to circulating GDF15 in mice, but muscle GDF15 might play a protective role in the exercise stress response.
Mirror, mirror on the outflow cavity wall
Authors: Fedriani R. , Caratti o Garatti A. , Koutoulaki M. , Garcia-Lopez R. , Natta A. , Cesaroni R. , Oudmaijer R. , Coffey D. , Ray T. , Stecklum B. 
Published: December 2019

Aims. The inner regions of high-mass protostars are often invisible in the near-infrared, obscured by thick envelopes and discs. We aim to investigate the inner gaseous disc of IRAS 11101-5829 through scattered light from the outflow cavity walls.
Methods. We observed the immediate environment of the high-mass young stellar object IRAS 11101-5829 and the closest knots of its jet, HH135-136, with the integral field unit VLT/SINFONI. We also retrieved archival data from the high-resolution long-slit spectrograph VLT/X-shooter. We analysed imaging and spectroscopic observations to discern the nature of the near-infrared CO emission.
Results. We detect the first three bandheads of the υ = 2−0 CO vibrational emission for the first time in this object. It is coincident with continuum and Brγ emission and extends up to ~10 000 au to the north-east and ~10 000 au to the south-west. The line profiles have been modelled as a Keplerian rotating disc assuming a single ring in local thermodynamic equilibrium. The model output gives a temperature of ~3000 K, a CO column density of ~1 × 1022 cm−2, and a projected Keplerian velocity vK sin idisc ~ 25 km s−1, which is consistent with previous modelling in other high-mass protostars. In particular, the low value of vK sin idisc suggests that the disc is observed almost face-on, whereas the well-constrained geometry of the jet imposes that the disc must be close to edge-on. This apparent discrepancy is interpreted as the CO seen reflected in the mirror of the outflow cavity wall.
Conclusions. From both jet geometry and disc modelling, we conclude that all the CO emission is seen through reflection by the cavity walls and not directly. This result implies that in the case of highly embedded objects, as for many high-mass protostars, line profile modelling alone might be deceptive and the observed emission could affect the derived physical and geometrical properties; in particular the inclination of the system can be incorrectly interpreted.
Another view of the maximum principle for infinite-horizon optimal control problems in economics
Authors: Aseev S. M. , Veliov V. M. 
Published: December 2019

Abstract
The authors present their recently developed complete version of the Pontryagin maximum principle for a class of infinite-horizon optimal control problems arising in economics. The main distinguishing feature of the result is that the adjoint variable is explicitly specified by a formula analogous to the Cauchy formula for solutions of linear differential systems. In certain situations this formula implies the ‘standard’ transversality conditions at infinity. Moreover, it can serve as an alternative to them. Examples demonstrate the advantages of the proposed version of the maximum principle. In particular, its applications are considered to Halkin’s example, to Ramsey’s optimal economic growth model, and to a basic model for optimal extraction of a non-renewable resource. Also presented is an economic interpretation of the characterization obtained for the adjoint variable.
Bibliography: 62 titles.
Deterministic actin waves as generators of cell polarization cues
Authors: Stankevicins Luiza , Ecker Nicolas , Terriac Emmanuel , Maiuri Paolo , Schoppmeyer Rouven , Vargas Pablo , Lennon-Duménil Ana-Maria , Piel Matthieu , Qu Bin , Hoth Markus , Kruse Karsten , Lautenschläger Franziska 
Published: December 2019

Significance
Dendritic cells are immune cells that migrate within the human body in search of pathogens. This search is performed by a random walk, which combines persistent and diffuse movements. The mechanism underlying this random walk is currently not known. We analyzed very long trajectories of dendritic cells ex vivo, and we describe here their characteristic persistent and diffusive patterns. Together with theoretical analysis, we provide evidence that the random walk of dendritic cells could be a consequence of the intrinsic actin dynamics without need for molecular noise or external polarization cues. Our results hint at the possibility that these cells can adapt their random search strategies by changing the spontaneous dynamics of their actin cytoskeleton.
Study on microstructure of NiAl matrix high temperature lubricating composites containing BaO/TiO2 metallic oxide
Authors: Li Bo , Gao Yimin , Li Cong , Kang Yunchuan , Zheng Qiaoling , Zhao Siyong 
Published: December 2019

Abstract
The microstructure of NiAl matrix high temperature lubricating composites containing BaO/TiO2 metallic oxides were investigated. The NiAl-BaO/TiO2 composites were fabricated by vacuum hot-pressing sintering. The diffraction peaks of NiAl slightly shifted to the left with the addition of BaO/TiO2 metallic oxide. The crystal plane distance of NiAl phase in the composite was bigger than that in NiAl material according to the Bragg equation. Meanwhile, the lattice distortion and dislocation occurred in the composite structure, which is probably due to the Ti element dissolve in the NiAl matrix during sintering. The cohesive energy and formation enthalpy of NiAl were improved with the incremental of Ti solution contents through density functional theory calculations, which was indicated that the Ti element could dissolve in the NiAl and was in good accordance with the results of XRD and TEM.
High wear resistance hypoeutectic Fe–C–B alloy by hot rolling
Authors: Li Feng , Li Zhenhua 
Published: December 2019

Abstract
A novel high wear resistance hypoeutectic Fe–C–B alloy by hot rolling with isolated hard lumps distributed in matrix is reported. The effect of deformation on microstructure and properties of the alloy during hot rolling process was systematically investigated. The results showed that with the increase of deformation, the continuous hard phase network in the alloy was crushed into isolated hard lumps, and the properties of the alloy were improved significantly. The alloy with 66.7% deformation displayed excellent mechanical properties with the impact value of 12.6 J while its hardness was still kept at 58.6 HRC. And the wear resistance of the alloy with 66.7% deformation was 1.21 times as that of the commercial Cr20Mo high chromium cast iron.
Changes in physical activity of adolescent girls in the context of their perception of the Healthy Me programme
Authors: Mazur Joanna , Dzielska Anna , Kleszczewska Dorota , Oblacińska Anna , Fijałkowska Anna 
Published: December 2019

Abstract

Background
An assumption was made that results of programme evaluation lead to better understanding for whom this intervention may work. The aim of the article is to compare the changes in physical activity of the intervention programme participants depending on subjective assessment of its impact.

Methods
The data were obtained from 14- to15-year-old Polish girls (N = 1120) from 48 random selected secondary schools participating in the 1-year Healthy Me programme in the 2017/2018. Schools were randomly assigned to one of two types of intervention or to a control (null) group. Satisfaction with the programme according to 21 criteria was measured retrospectively just after the intervention. Change in MVPA (moderate-to-vigorous physical activity) during the programme implementation was assessed in relation to satisfaction level, and adjusted for initial MVPA.

Results
In total, the MVPA did not change significantly comparing pre- and post-intervention surveys (3.94 ± 1.94 vs. 3.87 ± 1.93)—P = 0.093. However, the perceived notable improvement of functioning in 10 out of 21 areas was related to the unquestionable increase in MVPA (P ≤ 0.001). With respect to the four impact areas, an interaction was demonstrated between an intervention group and an improvement in the domain-specific functioning. The beneficial impact of the programme on these areas was associated with the improvement of physical activity only in case of full and null intervention.

Conclusions
Indicators related to the implementation process and the results obtained during the Healthy Me programme evaluation could represent a change in motivational and environmental factors that indirectly affects adolescent girl’s physical activity.