bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dichloromethane Fraction of Vernonia cinerea Impart Pro-Apoptotic, Genotoxic, Cell Cycle Arrest, and Drug Efflux Inhibitory Effects on Human Adenocarcinoma Cells
Authors: Beeran Asmy Appadath , Udupa Nayanabhirama , Maliyakkal Naseer 
Published: August 2020

Background:
Vernonia cinerea (VC) is an important medicinal plant used in the indigenous
system of therapy. In ethnomedicine, VC has demonstrated anticancer properties. However,
the mechanisms of action VC is not known.

Objective:
To establish the anticancer mechanisms of ‘bioactive fractions of VC’ on human adenocarcinoma
cells.

Methods:
The IC50 values of characterized VC extract and fractions in human adenocarcinoma and
normal epithelial cells were determined using Sulforhodamine B (SRB) assay. Acridine Orange-
Ethidium Bromide (AO-EB) assay/Hoechst 33342 assay, Comet assay, and Cell cycle analysis
were used to determine apoptosis, genotoxicity, and cell cycle-specific changes in cancer cells, respectively.
Rhodamine 123 (Rho-123) efflux assay and Mitoxantrone (MX) efflux assay were used
to assess the inhibition of Multidrug Resistance (MDR) transporters.

Results:
The dichloromethane fraction of VC (VC-DM) imparted dose-dependent cytotoxicity in
human adenocarcinoma cells with fewer effects in human normal epithelial cells. This ‘sesquiterpenoids’
enriched fraction (VC-DM) induced apoptosis, DNA damage, genotoxicity, and G2/M
phase arrest in human adenocarcinoma cells. Interestingly, VC-DM significantly inhibited the functional
activity of MDR transporters (ABCB1 and ABCG2) and caused ‘synergistic cytotoxic effects’
with anticancer drugs in human adenocarcinoma cells.

Conclusion:
The bioactivity guided fractionation of VC revealed that the specific ‘sesquiterpenoids
enriched fraction’ (VC-DM) imparted cytotoxicity in human adenocarcinoma cells with
fewer effects on normal cells. Mechanistic studies have shown that VC-DM induced apoptosis,
DNA damage, genotoxicity, cell cycle arrest (G2/M), inhibited the functional activity of MDR transporters
(ABCB1 and ABCG2), and produced ‘synergistic cytotoxic effects’ (combinatorial treatments
with anticancer drugs) in human adenocarcinoma cells. Taken together, the findings of this
study emphasize and validates VC-DM as a promising ‘anticancer agent’ against human adenocarcinomas,
including those with a multi-drug resistant phenotype.
In Vitro Anticancer Evaluation of Some Synthesized 2H-Quinolinone and Halogenated 2H-Quinolinone Derivatives as Therapeutic Agents
Authors: El-Aziz Rahma M. Abd , Zaki Islam , El-Deen Ibrahim M. , Abd-Rahman Marwa S. , Mohammed Faten Z. 
Published: August 2020

Background:
Searching for new cytotoxic agents with apoptosis induction may represent a viable
strategy for cancer treatment to overcome the increased resistance to available anticancer agents.

Objective:
The purpose of the current study was aimed at preparation and anticancer evaluation of two new
series of 2H-quinolinone and halogenated 2H-quinolinone derivatives against two cancer cell lines.

Methods:
Two new series of 2H-quinolinone and halogenated 2H-quinolinone derivatives were prepared and
screened for their cytotoxicity against breast MCF-7 and liver HepG-2 cancer cell lines as well as normal breast
MCF-10a.

Results:
The tested molecules revealed good cytotoxicity and selectivity toward cancer cell lines relative to
normal cells. These compounds were analyzed by DNA flow cytometry on MCF-7 cells. They were found to
cause G2/M phase arrest and induced apoptosis at the pre-G1 phase. In addition, increased caspase 3/7 activity
and decreased osteopontin expression verified the apoptotic activity.

Conclusion:
The potent compounds discovered in this study can be a hit for the discovery of new cytotoxic
agents and are worthy of further investigation.
Cyclotron Production of PET Radiometals in Liquid Targets: Aspects and Prospects
Authors: Pandey Mukesh K. , DeGrado Timothy R. 
Published: August 2020

:
The present review describes the methodological aspects and prospects of the production
of Positron Emission Tomography (PET) radiometals in a liquid target using low-medium energy
medical cyclotrons. The main objective of this review is to delineate and discuss the critical factors
involved in the liquid target production of radiometals, including type of salt solution, solution
composition, beam energy, beam current, the effect of irradiation duration (length of irradiation)
and challenges posed by in-target chemistry in relation with irradiation parameters. We also summarize
the optimal parameters for the production of various radiometals in liquid targets.

:
Additionally, we discuss the future prospects of PET radiometals production in the liquid targets
for academic research and clinical applications. Significant emphasis has been given to the production
of 68Ga using liquid targets due to the growing demand for 68Ga labeled PSMA vectors, [68Ga]-
Ga-DOTATATE, [68Ga]Ga-DOTANOC and some upcoming 68Ga labeled radiopharmaceuticals.
Other PET radiometals included in the discussion are 86Y, 63Zn and 89Zr.
Natural Resources for Sustainable Water Treatment - A Review
Authors: Karnena Manoj Kumar , Saritha Vara 
Published: August 2020

Background:
Purification and remediation of water remain to be a mammoth
challenge for environmental engineers, continuously mounting pressure on providing safe
water for consumers. Nevertheless, care has to be taken to avoid chemicals in treatment,
which could prove to be toxic. One of the most prominent stages in treating water for human
consumption is clarification through coagulation and flocculation to remove colloidal
particles including silt, clay, precipitated iron or manganese oxides along with bacteria and
algae.

Objective:
In order to achieve sustainability, the only possible way is to use innate materials
in combination with inherent technologies. Considering this, the present review will appraise
the efficiency of natural coagulants in treating surface water. Several researchers
have tested numerous natural coagulants for clarification of water. Nevertheless, information
on various natural coagulants and their efficiency has not yet been presented.

Methods:
Hence, an attempt is made to bring about a comprehensive account of various
natural coagulants and also to understand their properties and efficiencies in treating water.

Results:
Cumulative information regarding natural coagulants presented in this review will
add to the database of natural coagulants and can be adopted at various temporal and spatial
levels according to the availability of these coagulants to treat water. Nevertheless, precise
research on coagulation parameters and shelf life of treated water will enhance the opportunities
for point of use water treatment technologies.

Conclusion:
The current review presents natural coagulants having the potential to treat
surface water as sustainable alternatives to point of use treatment.
Quantization Algorithms in Healthcare Information Telematics Using
Wireless Interactive Services of Digital Video Broadcasting
Authors: Kardaras Konstantinos , Lambrou George I. , Koutsouris Dimitrios 
Published: August 2020

Background:
In the new era of wireless communications new challenges emerge including the
provision of various services over the digital television network. In particular, such services become more important when
referring to the tele-medical applications through terrestrial Digital Video Broadcasting (DVB).

Objective:
One of the most significant aspects of video broadcasting is the quality and information content of data.
Towards that end several algorithms have been proposed for image processing in order to achieve the most convenient
data compression.

Methods:
Given that medical video and data are highly demanding in terms of resources it is imperative to find methods
and algorithms that will facilitate medical data transmission with ordinary infrastructure such as DVB.

Results:
In the present work we have utilized a quantization algorithm for data compression and we have attempted to
transform video signal in such a way that would transmit information and data with a minimum loss in quality and
succeed a near maximum End-user approval.

Conclusions:
Such approaches are proven to be of great significance in emergency handling situations, which also include
health care and emergency care applications.
Association of Socioeconomic Changes due to the COVID-19 Pandemic With Health Outcomes in Patients With Skin Diseases: Cross-Sectional Survey Study
Authors: Guo Yeye , Shen Minxue , Zhang Xu , Xiao Yi , Zhao Shuang , Yin Mingzhu , Bu Wenbo , Wang Yan , Chen Xiang , Su Juan 
Published: August 2020

Background
The outbreak of COVID-19 has profoundly influenced people’s lifestyles; these impacts have varied across subgroups of people. The pandemic-related impacts on the health outcomes of people with dermatological conditions are unknown.

Objective
The aim of this paper was to study the association of COVID-19 pandemic–related impacts with health-related quality of life in patients with skin diseases.

Methods
This was a cross-sectional study among Chinese patients with skin diseases. A self-administered web-based questionnaire was distributed through social media. Demographic and clinical data and pandemic-related impacts (isolation status, income changes, and employment status) were collected. The main outcomes included perceived stress (Visual Analog Scale), symptoms of anxiety (Generalized Anxiety Disorder-7) and depression (9-Item Patient Health Questionnaire), quality of life (Dermatology Life Quality Index), and health utility mapping based on the EQ-5D-3L descriptive system. Multivariable logistic regression was used to investigate the associations.

Results
A total of 506 patients with skin diseases completed the survey. The mean age of the patients was 33.5 years (SD 14.0), and 217/506 patients (42.9%) were male. Among the 506 respondents, 128 (25.3%) were quarantined, 102 (20.2%) reported unemployment, and 317 (62.6%) reported decrease or loss of income since the pandemic. The pandemic-related impacts were significantly associated with impaired mental well-being and quality of life with different effects. Unemployment and complete loss of income were associated with the highest risks of adverse outcomes, with increases of 110% to 162% in the prevalence of anxiety, depression, and impaired quality of life.

Conclusions
Isolation, income loss, and unemployment are associated with impaired health-related quality of life in patients with skin diseases during the COVID-19 pandemic.
O aspecto contextual da textualidade via LSF numa intervenção pedagógica sobre a atividade tradutória
Authors: Vieira Teresinha Penaforte , Praxedes Filho Pedro Henrique Lima 
Published: August 2020

Neste artigo, buscamos relatar parte de uma pesquisa cujo objetivo foi investigar o desenvolvimento da subcompetência bilíngue e metarreflexão de tradutores em formação (HURTADO ALBIR, 2005; PACTE, 2003; VASCONCELLOS; PAGANO, 2005; entre outros) sobre aspectos relativos à textualidade/tessitura (HALLIDAY; MATTHIESSEN, 2014), no par linguístico português-inglês. A parte relatada trata apenas do aspecto ‘relação textos-contexto’. A pesquisa, orientada pela LSF e estudos da tradução, foi desenvolvida via intervenção pedagógica aplicada a bacharelandos em Língua Inglesa/Tradução da Universidade Estadual do Ceará. O corpus foi constituído pelas respostas a questões em cinco atividades pedagógicas e pelos comentários feitos em entrevistas inicial e final. Os resultados relativos à Atividade 1, sobre a relação textos-contexto, e a comentários na entrevista final demonstraram uma elevação no nível de subcompetência bilíngue dos participantes e de sua capacidade metarreflexiva sobre esse aspecto, tendo levado ao incremento de suas habilidades de leitura (no sentido amplo), o que, consequentemente, influencia suas escolhas tradutórias.
Processos mentais em experienciação de desejos e construção de identidades em moradores de um distrito de Pernambuco
Authors: Da Silva Junior Valmir Joaquim , Souza Maria Medianeira De 
Published: August 2020

O presente trabalho tem por objetivo investigar como se dá a experienciação do desejo em moradores do distrito de Tejucupapo, localizado no município de Goiana, no Estado de Pernambuco. O intuito foi perceber quais e como os desejos são construídos no discurso dessas pessoas, por meio do Processo Mental querer, e como aspectos identitários são revelados. Esta pesquisa é parte de uma dissertação de mestrado defendida na Universidade Federal de Pernambuco, em 2017. Para realizar este recorte, tomamos por base os pressupostos de Halliday & Matthiessen (2014) e Figueiredo (2011) sobre os Processos Mentais, especialmente os chamados Desiderativos, responsáveis por materializar os desejos, bem como Bucholtz e Hall (2005), entre outros, para discutir a noção de identidade. Após transcrição das entrevistas, foi realizado um mapeamento das ocorrências do Processo querer. A análise dos usos desse Processo mostrou que os desejos experienciados apontam para uma forte religiosidade, tendo em vista o expressivo número de ocorrências nas quais Deus e Jesus foram os Experienciadores. Também fomos capazes de ver como os participantes da pesquisa marcam suas identidades por meio da diferença, quando apontam que outros tejucupapenses têm anseios diferentes dos seus. Por fim, a análise revelou o otimismo e a esperança como traços particulares desses indivíduos.
Un nuevo paradigma de la responsabilidad social corporativa. El aumento de enfermedades crónico-degenerativas en la fuerza laboral
Authors: Leiner de la Cabada Marie , Ortiz Díaz Jesús Rodolfo , Ávila Maese Carmen 
Published: August 2020

<p>El aumento exponencial de las enfermedades crónico-degenerativas, que se han observado en<br />México en los últimos veinte años, amenaza reducir considerablemente en el futuro el número de años productivos de los empleados de todos los niveles jerárquicos. Ante la amenaza de que su fuerza laboral se vea afectada por el aumento en la prevalencia de enfermedades crónico-degenerativas, las corporaciones necesitan considerar la posibilidad de intervención. No se vislumbra detener la epidemia con medicinas o vacunas, sino con inéditas intervenciones y actores sin experiencia en el campo de la salud. Si las empresas deciden intervenir, podrían considerar estas actividades como un nuevo paradigma de la responsabilidad social corporativa.</p><p>Es por esto que en este trabajo se plantea la necesidad de que las empresas puedan contribuir a prevenir las enfermedades crónico-degenerativas de sus empleados con actividades dentro de sus programas de responsabilidad social. Se discute también el perfi l del profesional que<br />podría ser el encargado de estos programas, así como la importancia de revisar y replicar estrategias de éxito y no repetir los mismos errores y la importancia de considerar el costo beneficio de las actividades programadas.</p>
Perilaku-Perilaku Sosial Penyebab Peningkatan Risiko Penularan Malaria di Pangandaran
Authors: Ruliansyah Andri , Pradani Firda Yanuar 
Published: August 2020

Malaria is still a public health problem in Pangandaran Regency. Increasing imported malaria cases from year to year become the main problem since Pangandaran is a tourist destination and is currently doing development in the tourism sector. This study aimed to look at socio-cultural factors in the community that contribute to the increased risk of malaria transmission. This research was conducted with interviews and environmental observations. Respondents were randomly selected from the population living in the District of Pangandaran. The results showed that the habit of going out at night, traveling to endemic areas, and choosing potential breeding places around settlements or tourist attractions would increase the risk of malaria transmission in Pangandaran. In this context, health workers need to discuss and provide understanding to the community about the dangers of malaria transmission so that people become more concerned and make independent prevention eﬀ orts. The development of tourist destinations must also consider environmental factors sMalaria merupakan masalah kesehatan masyarakat yang ditemukan di wilayah Kabupaten Pangandaran. Peningkatan kasus malaria impor dari tahun ke tahun menjadi masalah terutama karena Pangandaran merupakan daerah tujuan wisata dan sedang melakukan pengembangan di sektor pariwisata. Penelitian ini bertujuan untuk melihat faktor sosial budaya di masyarakat yang memiliki potensi meningkatkan risiko penularan malaria. Penelitian ini dilakukan dengan wawancara dan pengamatan lingkungan. Responden dipilih secara acak dari penduduk yang tinggal di wilayah Kecamatan Pangandaran. Hasil penelitian menunjukkan bahwa kebiasaan keluar malam, kebiasaan bepergian/merantau ke luar kota termasuk ke daerah endemis dan keberadaan tempat perindukan potensial di sekitar pemukiman atau objek wisata akan meningkatkan risiko penularan malaria di Pangandaran. Dalam konteks ini, para petugas kesehatan perlu melakukan pendekatan menyeluruh dan memberikan pengertian kepada masyarakat tentang bahaya penularan malaria sehingga masyarakat menjadi lebih peduli dan melakukan upaya pencegahan secara mandiri. Pengembangan daerah wisata pun harus memperhatikan faktor-faktor lingkungan seperti letak tempat perindukan potensial Anopheles spp. uch as potential places for Anopheles spp brood.
Abstrak
Desarrollo Productivo Apícola como fuente de mejoramiento socioeconómico Vereda Corralejas Sotará Cauca
Authors: Velasco Hurtado Dora Silvana , Barreda Ramírez Concepción , Ordoñez Ortega Danny Astrid 
Published: August 2020

La presente investigación tuvo como objetivo general determinar el impacto del desarrollo productivo apícola en el mejoramiento socioeconómico de los apicultores, y así mismo, diseñar estrategias y plan de acción que logren incentivar la asociatividad y la participación en circuitos cortos de comercialización. Se presenta el diagnóstico abordado desde una metodología de enfoque mixto, aplicando análisis cuantitativo y cualitativo y un enfoque tipo explorativo, descriptivo y de observación. La metodología utilizada incluyó consulta a los habitantes y apicultores de la vereda Corralejas. Los instrumentos empleados fueron encuesta y entrevista. La población fue de 374 habitantes, una muestra de 190 personas a quienes se aplicó la encuesta y posteriormente, se aplicó entrevista a los apicultores, realizando notas de campo y registro fotográfico. De acuerdo con la información analizada, se evidencia incidencia e impacto de la apicultura en el sector económico, social y ambiental, teniendo en cuenta que aporta al mejoramiento de la calidad de vida de quienes trabajan en este subsector. Por otra parte, se ratifican beneficios de la apicultura y se determina como una actividad económica que genera ingresos adicionales, fortaleciendo la economía campesina, familiar y comunitaria, las sinergias entre actores del territorio, y la dinamización de la diversificación productiva.
Sistema de información de los indicadores de seguridad alimentaria y nutricional del Departamento de Caldas
Authors: Soto Alzate Derly Patricia 
Published: August 2020

El artículo presenta el desarrollo del Sistema de Información de los Indicadores de Seguridad Alimentaria y Nutricional del Departamento de Caldas, realizado con los expertos de la Red SAN del Departamento de Caldas y estudiantes de la asignatura Ingeniería de Software de octavo semestre del año 2013, del Programa de Ingeniería y Computación de la Universidad de Caldas, práctica académica en la que se aplican los procesos de desarrollo, Proceso Personal de Software –PSP e Introducción al Proceso de Software de Equipos TSPi.
Research Initiatives in Accounting Education: Transforming Today's Students into Accounting Professionals
Authors: Madsen Paul E. 
Published: August 2020

ABSTRACT
Accounting education is part of the causal chains that produce every accounting outcome of interest to researchers and practitioners because of its power to determine which people become accountants and to shape their traits through training. In this essay, I characterize the trait-shaping power of accounting education using a framework I call the “selection/transformation framework.” I then show how this framework can facilitate the generation of important, novel accounting education research questions using the examples of materialistic values among accounting students, the underrepresentation of Black people in audit firms, and the communication skills of accounting graduates. The research program I advocate would require the use of a variety of methods, but my examples focus on archival methods because of my familiarity with them and their relatively infrequent use in the accounting education literature.
Do We Matter? Attention the General Public, Policymakers, and Academics Give to Accounting Research
Authors: Burton F. Greg , Summers Scott L. , Wilks T. Jeffrey , Wood David A. 
Published: August 2020

ABSTRACT
Many question the value of accounting scholarship to society. We compare the attention the general public, policymakers, and academics give to academic accounting research relative to other business disciplines and other more general disciplines (economics, psychology, and other sciences). The results indicate that accounting research receives significantly less attention from the general public than all other disciplines and also performs relatively poorly in receiving policymakers' attention compared to both economics and finance. Within accounting subtopics, tax research receives more attention from the general public and policymakers than other topic areas. We also find that articles in other disciplines' elite journals cite relatively few of accounting's elite-level publications, but non-elite journal articles cite accounting research in similar numbers to other disciplines. Finally, we rank scholars, institutions, and journals by the attention they receive. We discuss how these findings could impact accounting education.
Data Availability: Requests for data may be made to the authors.
JENIS DAN PROSES PEMBENTUKAN ADJEKTIVA DALAM BAHASA MINANGKABAU DI KENAGARIAN SUNGAI ABANG KECAMATAN LUBUK ALUNG KABUPATEN PADANG PARIAMAN
Authors: Rahman Milna , Agustina Agustina , Manaf Ngusman Abdul 
Published: August 2020

This study aimed to describe (1) type adjectives in Minangkabau language in kenagarian Sungai Abang subdistrict Lubuk Alung district Padang Pariaman, and (2) the process of forming adjective in Minangkabau language in kenagarian Sungai Abang subdistric Lubuk Alung district Padang Pariaman. This type of research is qualitative research with descriptive method. The method of data collection was using the method of referring and recording technique. Analyzing the data was done in the form of activities as follows: (1) describes the recording data into written language, (2) identify the data in accordance with the format provided, (3) classify the data into the type and process of the formation of the adjective, and (4) do data deduction based on research result. The data of this research are sentence containing the adjectives expressed by the community in kenagarian Sungai Abang subdistrict Lubuk Alung district Padang Pariaman. The source of this research is Minangkabau language especially oral language of society in kenagarian Sungai Abang subdistrict Lubuk Alung district Padang Pariaman. Based on the results of the research obtained the following results, first adjectives in Minangkabau language in kenagarian Sungai Abang subdistrict Lubuk Alung district Padang Pariaman is as follows: (1) characteristic adjective (character or temperament), (2) color adjectives, (3) shape adjectives, (4) size adjectives, (5) sensory adjectives, (6) time adjectives, (7) distance adjectives, (8) speed adjectives, (9) power adjunctive adjectives, (10) adjectiva adjectives. Secondly, there are two adjunctive adjunctive processes in the Minangkabau language, which are basic adjectives and derivate adjectives that can be sorted on beraffixed adjectives, duplicated adjectives and compounded adjective adjectives. Keywords: Adjectives, Word-forming, Minangkabau Language