bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Creativity: Upgrading Creativity in Digital Business
Authors: Smailhodžić Edin , Berberović Denis 
Published: November 2020

AbstractCreativity has become one of the most important driving factors of today’s digital business environments. Businesses are increasingly looking for creative employees who can offer new and out-of-the-box solutions to existing problems. Companies go through the process of digital transformation by increasingly changing the ways in which they employ digital technologies and develop new digital business models that help to create and to capture value. Combined with a creative approach, companies have experienced a surge in creative digital solutions. However, the creative process is not a self-perpetuating mechanism. It must be initiated and supported by organizations. This is done by understanding the creative process itself and by making small but fruitful adjustments to the work environment and the overall management of the workforce. As three chosen real-life examples will illustrate, such approach results in unleashing powerful creative energy that offers new services to the market, new approaches to solving existing problems, or as seen in the case of Uber—bringing in a completely new business model based on creative solutions and innovative approaches to different aspects of business operations.
Was ist Ökonomie? Das Interdisziplinäre Studentische Kolloquium (ISK) an der Humboldt-Universität zu Berlin
Authors: Breljak Anja , Kersting Felix , Miersch Klaas , Stieglitz Timo , Wohnsiedler Iris 
Published: November 2020

ZusammenfassungDas Interdisziplinäre Studentische Kolloquium (ISK) ist ein seit 2013 an der Humboldt-Universität zu Berlin stattfindendes wöchentliches Format zur kritischen Diskussion von Ökonomietheorien und anderen wissenschaftlichen Ansätzen, die sich mit ökonomischen Fragen auseinandersetzen. Das ISK verfolgt dabei drei Ziele: 1) VWL stärker als politische Ökonomie zu verstehen, 2) interdisziplinäre Zugänge zu fördern und 3) die Teilnehmerinnen und Teilnehmer zu empowern. Für die Umsetzung dieser Ziele haben sich eine offene und inklusive Atmosphäre als ebenso förderlich erwiesen wie der Ansatz des selbstbestimmten und autodidaktischen Lernens. Die dauerhafte Schaffung eines Diskussions- und Reflexionsraums nach geisteswissenschaftlichem Vorbild führte unter anderem zu weiteren studentischen Seminaren und einigen veröffentlichten Texten.
Poetry-Slams als Impuls für eine subjektiv begründete Reflexion wirtschaftswissenschaftlicher Denk- und Sprachkulturen
Authors: Hahn Gabriela , Hantke Harald , Fischer Andreas 
Published: November 2020

ZusammenfassungPoetry Slams sind nicht nur unterhaltsam, auch machen sie Lyrik – und damit unterschiedliche sprachliche Ebenen – einem breiteren Publikum zugänglich. Doch birgt ihre Erarbeitung und Präsentation im Rahmen des wissenschaftlichen Hochschulstudiums auch das Potenzial, Bildungsprozesse anzustoßen, die Studierenden die Möglichkeit bieten, drängende gesellschaftliche Probleme zu reflektieren, einzuordnen, wissenschaftlich zu erörtern oder gar zu lösen? Oder anders gefragt: Bieten Poetry-Slams Studierenden die Möglichkeit, (sozio-)ökonomische Themen orientierend, reflektierend und verantwortungsvoll in ihrer eigenen Sprache zu erschließen und sich gemeinsam mit anderen intersubjektiv darüber auszutauschen? Einblicke in die Beantwortung dieser Fragen bietet der vorliegende Beitrag, der ein konkretes Lehr-Lern-Arrangement skizziert, durch das Studierende des Masterstudiengangs „Lehramt an berufsbildenden Schulen – Fachrichtung Wirtschaftswissenschaften“ dazu herausgefordert wurden, eigene Poetry-Slam-Texte zu erarbeiten, präsentieren und reflektieren.
AdS3 wormholes from a modular bootstrap
Authors: Cotler Jordan , Jensen Kristan 
Published: November 2020

Abstract
In recent work we computed the path integral of three-dimensional gravity with negative cosmological constant on spaces which are topologically a torus times an interval. Here we employ a modular bootstrap to show that the amplitude is completely fixed by consistency conditions and a few basic inputs from gravity. This bootstrap is notably for an ensemble of CFTs, rather than for a single instance. We also compare the 3d gravity result with the Narain ensemble. The former is well-approximated at low temperature by a random matrix theory ansatz, and we conjecture that this behavior is generic for an ensemble of CFTs at large central charge with a chaotic spectrum of heavy operators.
Model-dependence of minimal-twist OPEs in d > 2 holographic CFTs
Authors: Fitzpatrick A. Liam , Huang Kuo-Wei , Meltzer David , Perlmutter Eric , Simmons-Duffin David 
Published: November 2020

Abstract
Following recent work on heavy-light correlators in higher-dimensional conformal field theories (CFTs) with a large central charge CT, we clarify the properties of stress tensor composite primary operators of minimal twist, [Tm], using arguments in both CFT and gravity. We provide an efficient proof that the three-point coupling $$ \left\langle {\mathcal{O}}_L{\mathcal{O}}_L\left[{T}^m\right]\right\rangle $$

O
L

O
L

T
m

, where $$ {\mathcal{O}}_L $$

O
L

is any light primary operator, is independent of the purely gravitational action. Next, we consider corrections to this coupling due to additional interactions in AdS effective field theory and the corresponding dual CFT. When the CFT contains a non-zero three-point coupling $$ \left\langle TT{\mathcal{O}}_L\right\rangle $$

TT

O
L

, the three-point coupling $$ \left\langle {\mathcal{O}}_L{\mathcal{O}}_L\left[{T}^2\right]\right\rangle $$

O
L

O
L

T
2

is modified at large CT if $$ \left\langle TT{\mathcal{O}}_L\right\rangle \sim \sqrt{C_T} $$

TT

O
L

∼

C
T

. This scaling is obeyed by the dilaton, by Kaluza-Klein modes of prototypical supergravity compactifications, and by scalars in stress tensor multiplets of supersymmetric CFTs. Quartic derivative interactions involving the graviton and the light probe field dual to $$ {\mathcal{O}}_L $$

O
L

can also modify the minimal-twist couplings; these local interactions may be generated by integrating out a spin-ℓ ≥ 2 bulk field at tree level, or any spin ℓ at loop level. These results show how the minimal-twist OPE coefficients can depend on the higher-spin gap scale, even perturbatively.
Reduktion der Tinnituslautstärke
Authors: Schilling A. , Krauss P. , Hannemann R. , Schulze H. , Tziridis K. 
Published: November 2020

Zusammenfassung
Hintergrund
Tinnitus betrifft ca. 15 % der Bevölkerung, jedoch existiert noch immer kein echtes Heilverfahren. Ein von uns entwickeltes neuartiges Erklärungsmodell erlaubt nun die Erprobung einer gezielten, an den Ursachen der Tinnitusentstehung ansetzenden Behandlung. Diese basiert auf stochastischen Resonanzphänomenen an bestimmten synaptischen Verbindungen im Hörsystem, welche gezielt durch extern zugeführtes schwellennahes Rauschen induziert werden sollen.

Fragestellung
Die vorliegende Pilotstudie soll zeigen, ob ein spektral individuell angepasstes Rauschen erfolgreich chronischen tonalen/schmalbandigen Tinnitus während der Stimulation abschwächen kann.

Material und Methoden
Bei 22 volljährigen Tinnituspatienten (46.6±16.3 Jahre; 4 Frauen) wurden Hörverlust (HV) sowie Tinnitusfrequenzen (TF) und -lautstärken (TL) audiometrisch bestimmt. Darauf basierend wurden bis zu 8 verschiedene Rauschstimuli (RS) mit je 5 Lautstärken (−20 bis +20 dB SL) erzeugt. Diese wurden über audiologische Kopfhörer in einer Schallkammer für jeweils 40 s präsentiert. Nach jeder Präsentation wurde mithilfe einer 5‑stufigen Bewertungsskala (−2 bis +2) ermittelt, ob sich die TL verändert hat.

Ergebnisse
Es fanden sich Patienten ohne Verbesserung der TL (n = 6) und solche mit Verbesserung (n = 16), wobei hier RS um die TF besonders effektiv waren. Die Gruppen zeigten post hoc deutliche Unterschiede in den Audiogrammen: Offenbar ist das hier getestete Verfahren insbesondere bei normalhörenden Tinnituspatienten und solchen mit geringgradigem HV effektiv.

Schlussfolgerung
Die subjektiv wahrgenommene TL war bei 16 von 22 Probanden für die Dauer der Stimulation reduziert. Für den möglichen Erfolg einer zukünftigen Therapie scheint der HV relevant zu sein.
On the Complexity of the Smallest Grammar Problem over Fixed Alphabets
Authors: Casel Katrin , Fernau Henning , Gaspers Serge , Gras Benjamin , Schmid Markus L. 
Published: November 2020

AbstractIn the smallest grammar problem, we are given a word w and we want to compute a preferably small context-free grammar G for the singleton language {w} (where the size of a grammar is the sum of the sizes of its rules, and the size of a rule is measured by the length of its right side). It is known that, for unbounded alphabets, the decision variant of this problem is NP-hard and the optimisation variant does not allow a polynomial-time approximation scheme, unless P = NP. We settle the long-standing open problem whether these hardness results also hold for the more realistic case of a constant-size alphabet. More precisely, it is shown that the smallest grammar problem remains NP-complete (and its optimisation version is APX-hard), even if the alphabet is fixed and has size of at least 17. The corresponding reduction is robust in the sense that it also works for an alternative size-measure of grammars that is commonly used in the literature (i. e., a size measure also taking the number of rules into account), and it also allows to conclude that even computing the number of rules required by a smallest grammar is a hard problem. On the other hand, if the number of nonterminals (or, equivalently, the number of rules) is bounded by a constant, then the smallest grammar problem can be solved in polynomial time, which is shown by encoding it as a problem on graphs with interval structure. However, treating the number of rules as a parameter (in terms of parameterised complexity) yields W[1]-hardness. Furthermore, we present an $\mathcal {O}(3^{\mid {w}\mid })$
O
(

3

∣
w
∣

)
exact exponential-time algorithm, based on dynamic programming. These three main questions are also investigated for 1-level grammars, i. e., grammars for which only the start rule contains nonterminals on the right side; thus, investigating the impact of the “hierarchical depth” of grammars on the complexity of the smallest grammar problem. In this regard, we obtain for 1-level grammars similar, but slightly stronger results.
The diagnostic value of magnetic resonance imaging in differentiating benign and malignant pediatric ovarian tumors
Authors: Janssen Carlijn L. , Littooij Annemieke S. , Fiocco Marta , Huige Josephine C. B. , de Krijger Ronald R. , Hulsker Caroline C. C. , Goverde Angelique J. , Zsiros József , Mavinkurve-Groothuis Annelies M. C. 
Published: November 2020

Abstract
Background
The diagnostic workup of ovarian tumors in children and adolescents is challenging because preserving fertility, in addition to oncological safety, is of particular importance in this population. Therefore, a thorough preoperative assessment of ovarian tumors is required.

Objective
To investigate the diagnostic value of MR imaging in differentiating benign from malignant ovarian tumors in children and adolescents.

Materials and methods
We conducted a retrospective study of all children and adolescents age <18 years who underwent MR imaging of ovarian tumors during 2014–2019 at a pediatric specialty center. Two radiologists reviewed all MR imaging. We used pathology reports to define the histological diagnosis.

Results
We included 30 girls who underwent MR imaging for an ovarian tumor. Signs indicative for malignancy were tumors with a diameter ≥8 cm, with areas of contrast enhancement, irregular margins, extracapsular tumor growth, and ascites. All benign and malignant ovarian tumors were correctly identified by the radiologists.

Conclusion
The diagnostic utility of MR imaging in classifying ovarian tumors in children and adolescents as benign or malignant is promising and might aid in defining the indication for ovarian-sparing versus non-ovarian-sparing surgery. We recommend evaluating these tumors with MR imaging prior to deciding on surgical treatment.
Probing the effect of aroma compounds on the hydrodynamic properties of mucin glycoproteins
Authors: Dinu Vlad , MacCalman Thomas , Yang Ni , Adams Gary G. , Yakubov Gleb E. , Harding Stephen E. , Fisk Ian D. 
Published: November 2020

AbstractAroma compounds are diverse low molecular weight organic molecules responsible for the flavour of food, medicines or cosmetics. Natural and artificial aroma compounds are manufactured and used by the industry to enhance the flavour and fragrance of products. While the low concentrations of aroma compounds present in food may leave no effect on the structural integrity of the mucosa, the effect of concentrated aroma volatiles is not well understood. At high concentrations, like those found in some flavoured products such as e-cigarettes, some aroma compounds are suggested to elicit a certain degree of change in the mucin glycoprotein network, depending on their functional group. These effects are particularly associated with carbonyl compounds such as aldehydes and ketones, but also phenols which may interact with mucin and other glycoproteins through other interaction mechanisms. This study demonstrates the formation of such interactions in vitro through the use of molecular hydrodynamics. Sedimentation velocity studies reveal that the strength of the carbonyl compound interaction is influenced by compound hydrophobicity, in which the more reactive short chain compounds show the largest increase in mucin-aroma sedimentation coefficients. By contrast, the presence of groups that increases the steric hindrance of the carbonyl group, such as ketones, produced a milder effect. The interaction effects were further demonstrated for hexanal using size exclusion chromatography light scattering (SEC-MALS) and intrinsic viscosity. In addition, phenolic aroma compounds were identified to reduce the sedimentation coefficient of mucin, which is consistent with interactions in the non-glycosylated mucin region.
Precipitation response to extreme soil moisture conditions over the Mediterranean
Authors: Ardilouze Constantin , Materia Stefano , Batté Lauriane , Benassi Marianna , Prodhomme Chloé 
Published: November 2020

AbstractThe intimate link between soil moisture and precipitation makes it a “chicken-and-egg situation” that challenges climate studies of the continental water cycle. This association is particularly acute over the Mediterranean, increasingly exposed to droughts with climate change. This study aims at deciphering the impact of spring soil moisture state in the Mediterranean on subsequent warm season precipitation. In an idealized setup, two distinct climate models are used to generate extreme dry or wet soil conditions, and run climate simulations initialized and/or forced by these conditions. Changes in precipitation distribution and persistence are analyzed and where applicable compared to composites from a reanalysis. Spring soil moisture anomalies are found to be very persistent, but the precipitation response is largely model dependent. Overall, dry soils lead to a reduction of precipitation for early summer months and conversely for wet soils although with a fainter and less robust signal. On the other hand, wet soils tend to favor the persistence of precipitation throughout summer over several sub-regions. Our results highlight the stringent need to reduce the wide array of uncertainties associated to soil moisture, land-atmosphere coupling and convection in climate models, before ascertaining that soil moisture initialization could provide more skillful sub-seasonal to seasonal precipitation prediction.
Comparison of mechanical circulatory support with venoarterial extracorporeal membrane oxygenation or Impella for patients with cardiogenic shock: a propensity-matched analysis
Authors: Karatolios Konstantinos , Chatzis Georgios , Markus Birgit , Luesebrink Ulrich , Ahrens Holger , Divchev Dimitar , Syntila Styliani , Jerrentrup Andreas , Schieffer Bernhard 
Published: November 2020

Abstract
Background
Percutaneous mechanical circulatory devices are increasingly used in patients with cardiogenic shock (CS). As evidence from randomized studies comparing these devices are lacking, optimal choice of the device type is unclear. Here we aim to compare outcomes of patients with CS supported with either Impella or vaECMO.

Methods
Retrospective single-center analysis of patients with CS, from September 2014 to September 2019. Patients were assisted with either Impella 2.5/CP or vaECMO. Patients supported ultimately with both devices were analyzed according to the first device implanted. Primary outcomes were hospital and 6-month survival. Secondary endpoints were complications. Survival outcomes were compared using propensity-matched analysis to account for differences in baseline characteristics between both groups.

Results
A total of 423 patients were included (Impella, n = 300 and vaECMO, n = 123). Survival rates were similar in both groups (hospital survival: Impella 47.7% and vaECMO 37.3%, p = 0.07; 6-month survival Impella 45.7% and vaECMO 35.8%, p = 0.07). There was no significant difference in survival rates, even after adjustment for baseline differences (hospital survival: Impella 50.6% and vaECMO 38.6%, p = 0.16; 6-month survival Impella 45.8% and vaECMO 38.6%, p = 0.43). Access-site bleeding and leg ischemia occurred more frequently in patients with vaECMO (17% versus 7.3%, p = 0.004; 17% versus 7.7%, p = 0.008).

Conclusions
In this retrospective analysis of patients with CS, treatment with Impella 2.5/CP or vaECMO was associated with similar hospital and 6-month survival rates. Device-related access-site vascular complications occurred more frequently in the vaECMO group. A randomized trial is warranted to examine the effects of these devices on outcomes and to determine the optimal device choice in patients with CS.
The 3rd Level – Entwicklung der Feinstzerkleinerung und Ausbau der Flotation am Lehrstuhl für Aufbereitung und Veredlung
Authors: Böhm Andreas , Mayer Michael , Ressel Gerald 
Published: November 2020

ZusammenfassungIm Februar dieses Jahres konnte der Lehrstuhl für Aufbereitung und Veredlung auf Basis von lehrstuhlinternen Forschungsarbeiten zur Zerkleinerungstechnik in Kooperation mit dem „Materials Center Leoben Forschung GmbH“ (MCL) die Laboratorien in den 3. Stock des Impulszentrums für Rohstoffe und damit um eine Gesamtfläche von ca. 175 m2 ausdehnen. Mit finanzkräftiger Unterstützung durch die Montanuniversität Leoben, die zwei Anträge der Lehrstuhlleitung (hausinterne Impulsprogramme) positiv bewertete, konnte die apparative Ausrüstung aufgebaut werden, um die Forschungsziele Energieoptimierte Feinstzerkleinerung <5 µm, Smart processing und Integrale Prozessführung „mill as reactor“ in Angriff zu nehmen. Daneben werden ein zusätzliches Flotationslabor und Räumlichkeiten für Analytik mit Ende des Jahres einsatzbereit sein.Eine mobile Pilotanlage zur Rührwerkskugelmühlenmahlung und eine Labormühle für kryogene Mahlung sowie Mahlung bei erhöhtem Gasdruck sind die Anlagen, die in unterschiedlichen Forschungsprojekten erprobt, genutzt und zur Prozessreife geführt werden sollen.Die technische Erweiterung erschließt dem Lehrstuhl die Feinstzerkleinerung, Anlagenauslegung, Automatisierung von Zerkleinerungsabläufen und Prozessentwicklung jenseits des herkömmlichen Einsatzes von Mühlen in der Primär- und Sekundärrohstoffaufbereitung.
The effects of art therapy on anxiety, depression, and quality of life in adults with cancer: a systematic literature review
Authors: Bosman J. T. , Bood Z. M. , Scherer-Rath M. , Dörr H. , Christophe N. , Sprangers M. A. G. , van Laarhoven H. W. M. 
Published: November 2020

Abstract
Purpose
While there is increasing evidence for the effectiveness of psychosocial support programs for cancer patients, little attention has been paid to creativity or art as a way of addressing their psychological problems and improving quality of life. This review provides an overview of interventional studies that investigate the effects of art therapy interventions on anxiety, depression, and quality of life in adults with cancer.

Methods
We conducted a literature review with a systematic search. The databases PubMed/MEDLINE, PsycINFO, and EMBASE were searched for articles on art therapy among adult (18 years and above) cancer patients, published between September 2009 up to September 2019. Search terms were established for each database specifically. A total of 731 publications was assessed for relevance by title and abstract. The remaining 496 articles were examined using three inclusion criteria: interventions were guided by an artist or art therapist, participants were actively involved in the creative process, and anxiety, depression, and/or quality of life were included as outcome measures. Methodological quality of the included studies was appraised using specific checklists.

Results
Seven papers met the inclusion criteria. Data was extracted from three non-randomized intervention studies and four randomized controlled trials. All studies used a quantitative design with validated outcome measures. Four articles described positive effects of art therapy on anxiety, depression, or quality of life in adults with cancer.

Conclusion
Art therapy could possibly help decrease symptoms of anxiety and depression, and improve quality of life in adult cancer patients. However, because of the heterogeneity of the interventions and limited methodological quality of the studies, further research using stringent methods is needed.
Tetraparesis and sensorimotor axonal polyneuropathy due to co-occurrence of Pompe disease and hereditary ATTR amyloidosis
Authors: Zimmermann Milan , Deininger Natalie , Willikens Sophia , Haack Tobias B. , Grundmann-Hauser Kathrin , Streubel Berthold , Schreiber Melanie , Lerche Holger , Grimm Alexander 
Published: November 2020

Abstract
Introduction/aims
Hereditary transthyretin amyloidosis with polyneuropathy (hATTRPN) is an autosomal dominant multi-organ disorder manifesting in the third to fifth decade with the key clinical features of distal and painful sensory loss of the lower limbs and autonomic dysregulation. Motor neuropathy and cardiomyopathy evolve in the course of the disease. Pompe disease is an autosomal recessive disease leading to decreased levels of lysosomal enzyme acid α-glucosidase and proximal muscle weakness. We report the clinical features and diagnostic workup in the rare case of a patient with ATTR amyloidosis and late-onset Pompe disease, both genetically confirmed.

Methods
We performed a detailed clinical assessment, exome sequencing, and biochemical measurements.

Results
The patient presented with a distal, painful hypaesthesia of both legs, a cardiomyopathy, and a muscle weakness in the form of a girdle-type pattern of the arms and legs at the beginning and a spreading to distal muscle groups in the course of disease.

Discussion
This study highlights the importance of searching for co-occurrence of rare monogenetic neuromuscular diseases, especially in cases in which all clinical features can be readily explained by a single gene defect.