bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bar and Hinge Model for Simulating Bistability in Origami Structures With Compliant Creases
Authors: Zhu Yi , Filipov Evgueni T. 
Published: January 2020

Abstract
Active origami structures usually have creases made with soft and compliant plates because it is difficult to fabricate real hinges and actuate them. However, most conventional origami modeling techniques fail to capture these compliant creases and simplify them as concentrated rotational springs, which neglects torsional and extensional deformations of the creases. In this paper, an improved formulation of a bar and hinge model is proposed to explicitly capture the geometry and the flexibility of compliant creases with nonnegligible width in an origami, and the model is verified against finite element simulations. The verification shows that the model performs relatively well despite being simple and computationally inexpensive. Moreover, simulation examples demonstrate that the proposed model can capture the bistable behavior of the compliant crease origami with nonnegligible crease width because it explicitly includes the extensional stretching energy into the simulation framework and allows torsional crease deformations.
Machine Learning-Based Reverse Modeling Approach for Rapid Tool Shape Optimization in Die-Sinking Micro Electro Discharge Machining
Authors: Surleraux Anthony , Lepert Romain , Pernot Jean-Philippe , Kerfriden Pierre , Bigot Samuel 
Published: January 2020

Abstract
This paper focuses on efficient computational optimization algorithms for the generation of micro electro discharge machining (µEDM) tool shapes. In a previous paper, the authors presented a reliable reverse modeling approach to perform such tasks based on a crater-by-crater simulation model and an outer optimization loop. Two-dimensional results were obtained but 3D tool shapes proved difficult to generate due to the high numerical cost of the simulation strategy. In this paper, a new reduced modeling optimization framework is proposed, whereby the computational optimizer is replaced by an inexpensive surrogate that is trained by examples. More precisely, an artificial neural network (ANN) is trained using a small number of full reverse simulations and subsequently used to directly generate optimal tool shapes, given the geometry of the desired workpiece cavity. In order to train the ANN efficiently, a method of data augmentation is developed, whereby multiple features from fully simulated EDM cavities are used as separate instances. The performances of two ANN are evaluated, one trained without modification of process parameters (gap size and crater shape) and the second trained with a range of process parameter instances. It is shown that in both cases, the ANN can produce unseen tool shape geometries with less than 6% deviation compared to the full computational optimization process and at virtually no cost. Our results demonstrate that optimized tool shapes can be generated almost instantaneously, opening the door to the rapid virtual design and manufacturability assessment of µEDM die-sinking operations.
Cross-sectional study using primary care and cancer registration data to investigate patients with cancer presenting with non-specific symptoms
Authors: Pearson Clare , Poirier Veronique , Fitzgerald Karen , Rubin Greg , Hamilton Willie 
Published: January 2020

IntroductionPatients presenting to primary care with site-specific alarm symptoms can be referred onto urgent suspected cancer pathways, whereas those with non-specific symptoms currently have no dedicated referral routes leading to delays in cancer diagnosis and poorer outcomes. Pilot Multidisciplinary Diagnostic Centres (MDCs) provide a referral route for such patients in England.ObjectivesThis work aimed to use linked primary care and cancer registration data to describe diagnostic pathways for patients similar to those being referred into MDCs and compare them to patients presenting with more specific symptoms.MethodsThis cross-sectional study linked primary care data from the National Cancer Diagnosis Audit (NCDA) to national cancer registration and Route to Diagnosis records. Patient symptoms recorded in the NCDA were used to allocate patients to one of two groups - those presenting with symptoms mirroring referral criteria of MDCs (non-specific but concerning symptoms (NSCS)) and those with at least one site-specific alarm symptom (non-NSCS). Descriptive analyses compared the two groups and regression analysis by group investigated associations with long primary care intervals (PCIs).ResultsPatients with NSCS were more likely to be diagnosed at later stage (32% stage 4, compared with 21% in non-NSCS) and via an emergency presentation (34% vs 16%). These patients also had more multiple pre-referral general practitioner consultations (59% vs 43%) and primary care-led diagnostics (blood tests: 57% vs 35%). Patients with NSCS had higher odds of having longer PCIs (adjusted OR: 1.24 (1.11 to 1.36)). Patients with lung and urological cancers also had higher odds of longer PCIs overall and in both groups.ConclusionsDifferences in the diagnostic pathway show that patients with symptoms mirroring the MDC referral criteria could benefit from a new referral pathway.
Modified cosmology models from thermodynamical approach
Authors: Geng Chao-Qiang , Hsu Yan-Ting , Lu Jhih-Rong , Yin Lu 
Published: January 2020

AbstractWe apply the first law of thermodynamics to the apparent horizon of the universe with the power-law corrected and non-extensive Tsallis entropies rather than the Bekenstein–Hawking one. We examine the cosmological properties in the two entropy models by using the CosmoMC package. In particular, the first numerical study for the cosmological observables with the power-law corrected entropy is performed. We also show that the neutrino mass sum has a non-zero central value with a relaxed upper bound in the Tsallis entropy model comparing with that in the $$\Lambda $$ΛCDM one.
A class of solitons in Maxwell-scalar and Einstein–Maxwell-scalar models
Authors: Herdeiro Carlos A. R. , Oliveira João M. S. , Radu Eugen 
Published: January 2020

AbstractRecently, no-go theorems for the existence of solitonic solutions in Einstein–Maxwell-scalar (EMS) models have been established (Herdeiro and Oliveira in Class Quantum Gravity 36(10):105015, 2019). Here we discuss how these theorems can be circumvented by a specific class of non-minimal coupling functions between a real, canonical scalar field and the electromagnetic field. When the non-minimal coupling function diverges in a specific way near the location of a point charge, it regularises all physical quantities yielding an everywhere regular, localised lump of energy. Such solutions are possible even in flat spacetime Maxwell-scalar models, wherein the model is fully integrable in the spherical sector, and exact solutions can be obtained, yielding an explicit mechanism to de-singularise the Coulomb field. Considering their gravitational backreaction, the corresponding (numerical) EMS solitons provide a simple example of self-gravitating, localised energy lumps.
New explanation for accelerated expansion and flat galactic rotation curves
Authors: Sheykhi Ahmad 
Published: January 2020

AbstractEmploying the non-additive Tsallis entropy, $$S\sim A^{\beta }$$S∼Aβ, for the large-scale gravitational systems, we disclose that in the cosmological scales both the Friedmann equation and the equation of motion for Newtonian cosmology get modified, respectively. We then derive the modified Newton’s law of gravitation which is valid on large scales. We show that, in the relativistic regime, the modified Friedmann equation admits an accelerated expansion, for a universe filled with ordinary matter, without invoking any kind of dark energy, provided the non-extensive parameter is chosen $$\beta <1/2$$β<1/2. In the non-relativistic regime, however, the modified Newton’s law of gravitation can explain the flat galactic rotation curves without invoking particle dark matter provided $$\beta \lesssim 1/2$$β≲1/2. Our study may be regarded as an alternative explanation for the “dark side of the universe”, through modification of the gravitational field equations.
Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry
Authors: Smyth Lillian M. , Zhou Qin , Nguyen Bastien , Yu Celeste , Lepisto Eva M. , Arnedos Monica , Hasset Michael J. , Lenoue-Newton Michele L. , Blauvelt Natalie , Dogan Semih , Micheel Christine M. , Wathoo Chetna , Horlings Hugo , Hudecek Jan , Gross Benjamin E. , Kundra Ritika , Sweeney Shawn M. , Gao JianJiong , Schultz Nikolaus , Zarski Andrew , Gardos Stuart M. , Lee Jocelyn , Sheffler-Collins Seth , Park Ben H. , Sawyers Charles L. , André Fabrice , Levy Mia , Meric-Bernstam Funda , Bedard Philippe L. , Iasonos Alexia , Schrag Deborah , Hyman David M. 
Published: January 2020

Abstract

AKT inhibitors have promising activity in AKT1E17K-mutant estrogen receptor (ER)–positive metastatic breast cancer, but the natural history of this rare genomic subtype remains unknown. Utilizing AACR Project GENIE, an international clinicogenomic data-sharing consortium, we conducted a comparative analysis of clinical outcomes of patients with matched AKT1E17K-mutant (n = 153) and AKT1–wild-type (n = 302) metastatic breast cancer. AKT1-mutant cases had similar adjusted overall survival (OS) compared with AKT1–wild-type controls (median OS, 24.1 vs. 29.9, respectively; P = 0.98). AKT1-mutant cases enjoyed longer durations on mTOR inhibitor therapy, an observation previously unrecognized in pivotal clinical trials due to the rarity of this alteration. Other baseline clinicopathologic features, as well as durations on other classes of therapy, were broadly similar. In summary, we demonstrate the feasibility of using a novel and publicly accessible clincogenomic registry to define outcomes in a rare genomically defined cancer subtype, an approach with broad applicability to precision oncology.

Significance:
We delineate the natural history of a rare genomically distinct cancer, AKT1E17K-mutant ER-positive breast cancer, using a publicly accessible registry of real-world patient data, thereby illustrating the potential to inform drug registration through synthetic control data.
See related commentary by Castellanos and Baxi, p. 490.
Design and implementation speed control system of DC Motor based on PID control and matlab simulink
Authors: Hammoodi Salman Jasim , Flayyih Kareem Sayegh , Hamad Ahmed Refaat 
Published: January 2020

<span>In this paper, we first write a description of the operation of DC motors taking into account which parameters the speed depends on thereof. The PID (Proportional-Integral-Derivative) controllers are then briefly described, and then applied to the motor speed control already described , that is, as an electronic controller (PID), which is often referred to as a DC motor. The closed loop speed control of a Brush DC motor is developed applying the well-known PID control algorithm. The objective of this work is to designed and simulate a new control system to keep the speed of the DC motor constant before variations of the load (disturbances), automatically depending to the PID controller. The system was designed and implementation by using MATLAB/SIMULINK and DC motor.</span>
A smart energy consumption manager based on protues simulation
Authors: Mohammed Mohammed Abdulhussein , Farhood Alaa Desher , Abid Ahmed Jabbar 
Published: January 2020

<p>In the proposed system, a strategy for the control of energy consumption by home appliances is provided. The statistics of previous energy production and consumption of a case study city are used in providing the strategy. In the design of the proposed system, home appliances are categorized into three levels of priority, even though it can be more than three. In this article the control of energy consumption is achieved using a real time energy consumption manager (ECM) based on stored data without the need for real time communication. The system which is proposed here is affordable and simple. Also, it does not require grid upgrade or power line communication through the grid. </p>
Design a nine-level modular multilevel converter for DC railway electrification system
Authors: Toh Chuen Ling , Ooi P. C. 
Published: January 2020

<p>A recuperating converter is highly demanded in traction power substation to deliver the braking energy generated by a traction vehicle. Conventional voltage source inverter had been implemented in the traction power station. However, large ac line filters must be installed to improve the quality of ac voltages and currents. This paper proposes to install a nine-level Modular Multilevel Converter (MMC) as a recuperating converter. The main aim is to eliminate the need of ac line filters while producing good quality of ac voltage and current waveforms. The MMC is designed and modelled using MATLAB/Simulink Simulation tool. A centralized control of balancing all the sub-module capacitor voltage level is proposed with Third Harmonic Voltage Injection Level Shifted Pulse Width Modulation (THVI-LSPWM) technique. The simulation results prove that with the application of MMC, good quality of ac voltages and currents are being produced. The Total Harmonic Distortion indexes are found less than 3.5 % without using any ac line filters in the system. In addition, the classic DC link capacitance has also being eliminated. </p>
Design and implementation of high frequency induction heating with LLC resonant load matching using ELTA
Authors: Karuppusamy Suganthi , V Sunandhitha , R Suraj , S Roja T , K Sundararaman 
Published: January 2020

Induction heating is a non-contact method of producing heat which can be used to perform various processes like hardening, annealing, tempering, welding, brazing, melting, forging, etc. This paper discusses the design and implementation of induction heating on a given work-piece, using an LLC resonant circuit and a transformer for impedance matching, so as to transfer a maximum power of 5KW to the load. The load parameters are found out using ELTA software which calculates the values based on the dimensions of the work piece, operating frequency and temperature. The inverter used is based on SiC MOSFETs which minimizes the losses at high frequencies and high temperatures. The theoretical and simulated results from MATLAB are analysed and verified. The hardware is implemented for the LLC circuit with transformer and the results are presented.
Electrical profile of ultra violet (UV) curable renewable polymer graphite (PG) composites
Authors: Abdullah Nur Munirah , Rus A. Z. M. , Abdullah M. F. L. , Wahab Hanani Abd 
Published: January 2020

<span>The electrical profiles of the renewable polymer graphite (PG) composites upon ultra violet (UV) curing were investigated. Renewable PG films were prepared by mixing with varying weight percent of graphite (with an increment of 5 wt. % of prepared graphite) up to 30 wt.% and crosslinker. Then, the composites solution was slip casted and cured upon stimulated UV irradiation (UV accelerated weathering tester) at different time exposure (up to 1000 hours) was applied. Small changes on the functional groups of the composites were observed due to UV exposure time by Fourier Transform Infrared Spectroscopy (FTIR). Suggesting that chemical crosslink and chain scissions occurred within renewable polymer graphite composites. Further electrical profile through two point probe and four point probe method recorded visibly fluctuating values for both resistivity and conductivity within its composites range. Proposed here that the removal of organic contaminants and weak materials form both renewable polymer and graphite particles through the UV curing may have an effect on the formation of conductive network stability. </span>
Varieties of Developmentalism: A Critical Assessment of the PT Governments
Authors: Prates Daniela Magalhães , Fritz Barbara , de Paula Luiz Fernando 
Published: January 2020

To what extent did the PT governments follow developmentalist policies? A critical assessment reveals that they combined two varieties of developmentalism in different ways over time, with a surprisingly high frequency of policy changes, and that orthodox policies played a prominent role in part of this time span. Até que ponto os governos do PT seguiram políticas desenvolvimentistas? Uma avaliação crítica revela que eles combinaram duas variedades de desenvolvimentismo de maneiras diferentes ao longo do tempo, com uma frequência surpreendentemente alta de mudanças de políticas, e que as políticas ortodoxas tiveram um papel de destaque em parte desse período.
In vivo carbon dioxide clearance of a low-flow extracorporeal carbon dioxide removal circuit in patients with acute exacerbations of chronic obstructive pulmonary disease
Authors: Barrett Nicholas A , Hart Nicholas , Camporota Luigi 
Published: January 2020

Background: Veno-venous extracorporeal carbon dioxide removal allows clearance of CO2 from the blood and is becoming popular to enhance protective mechanical ventilation and assist in the management of acute exacerbations of chronic obstructive pulmonary disease, including the prevention of intubation. The main factor determining CO2 transfer across a membrane lung for any given blood flow rate and venous CO2 content is the sweep gas flow rate. The in vivo characteristics of CO2 clearance using ultra-low blood flow devices in patients with acute exacerbations of chronic obstructive pulmonary disease has not been previously described. Methods: Patients commenced on extracorporeal carbon dioxide removal for acute exacerbations of chronic obstructive pulmonary disease recruited to a randomized controlled trial of non-invasive ventilation versus extracorporeal carbon dioxide removal had pre- and post-membrane circuit gases measured after each increment of sweep gas flow to allow calculation of the transmembrane CO2 clearance. This was compared with the clearance reported by the device and also corrected to inlet PCO2 to allow characterization of the CO2 clearance of the device at different sweep gas flow rates. Results: CO2 clearance was calculated using both the transmembrane CO2 whole-blood content difference and CO2 clearance reported by the device. The two methods demonstrated a linear relationship and agreement with a bias of 14 mL/minute (SD = ±10) and an R2 of 0.92. The membrane CO2 clearance was non-linear with nearly two thirds of total clearance achieved with sweep gas flow below 2 L/minute (VCO2 of 40 ± 16.7 mL/minute) and a plateau above 5 L/minute sweep gas flow (VCO2 64 ± 1 2.4 mL/minute). Conclusion: The extracorporeal carbon dioxide removal device used in the study provides efficient clearance of CO2 at low sweep flow rates which then plateaus. This has implications for how the device may be used in clinical practice, particularly during the weaning phase where the final discontinuation of the device may take longer than anticipated. (ClinicalTrials.gov: NCT02086084, registered 13 March 2014, https://clinicaltrials.gov/ct2/show/NCT02086084 )
A better inferior vena cava filter retrieval rate: A retrospective study in a single-center institution
Authors: Cao Pengkai , Li Yunsong , Liu Xiangdong , Li Liang , Li Haitao , Zhang Xianchao , Hao Qingchun , Zhang Yanrong 
Published: January 2020

Purpose To determine practice patterns of inferior vena cava filters (IVCFs), retrieval rates, and reasons why retrievable-IVCFs (R-IVCFs) are kept permanent. Methods A total of 399 patients who received IVCFs at Third Hospital of Hebei Medical University from January 2017 to December 2017 were registered and retrospectively studied. Date of demographics, baseline medical history, dwell time, reasons why R-IVCFs were kept permanent, and R-IVCFs thrombus were collected. Results A total of 399 IVCFs were placed during the study period including 27 permanent IVCFs and 372 R-IVCFs. Among all patients who received R-IVCFs, the mean dwell time was 18.25 ± 16.60 days, follow-up rate was 96.24% (358/372), and 337 R-IVCFs were attempted to be removed. Except one, 336 R-IVCFs were retrieved successfully (336/372, 90.32%). Sixty-four R-IVCFs thrombi were found during retrieval including 53 small-size thrombi (< 1 cm × 1 cm) and 13 large-size thrombi (>1 cm × 1 cm). Fifty-three R-IVCFs with small-size thrombi were removed successfully with no additional treatments. Twelve large-size thrombi were retrieved successfully after catheter-directed thrombolysis. Conclusions With good follow-up, the retrieval rate could be improved to 90.32%. The main reasons why R-IVCFs were kept permanent were to avoid losing follow-up and overcome inappropriate selections of indications or IVCF types. And R-IVCFs with thrombus could be removed safely.
Endomyocardial biopsies in the diagnosis of myocardial involvement in systemic lupus erythematosus
Authors: Gartshteyn Y , Tamargo M , Fleischer S , Kapoor T , Li J , Askanase A , Winchester R , Geraldino-Pardilla L 
Published: January 2020

Background Endomyocardial biopsy (EMB) is considered the gold standard for diagnosing myocardial involvement in most inflammatory conditions, including systemic lupus erythematosus (SLE). However, EMBs are rarely performed, and most of the myocardial histopathology reports in SLE consist of postmortem data. We therefore sought to describe the histopathologic findings of contemporary EMBs in SLE performed in clinical practice. Methods A retrospective review of histopathology reports from SLE patients who underwent EMB from 1994 to 2017 was performed. A total of 41 SLE patients had cardiac pathology reports. Of these, 11 histopathology reports were EMBs, and the remaining were valvular specimens. Results A total of 11 SLE EMBs were reviewed. It was found that 45% of the patients had hypertension, 27% had coronary artery disease, 9% had hyperlipidemia, and 36% had end-stage renal disease. None had diabetes or smoked. The mean left ventricular ejection fraction was 37%. On histopathology, 10 had mild interstitial fibrosis, 9 had myocyte hypertrophy, 3 had organized blood clots, and 3 had a mild infiltration of lymphocytes and macrophages without clear evidence of myocarditis. None had vasculitis, endocarditis, ischemia, amyloid deposition, or lamellar or curvilinear inclusions. Conclusion EMBs are rarely performed in SLE. In this case series, nonspecific interstitial fibrosis and myocyte hypertrophy were the most common findings, suggesting EMBs have limited value in the diagnosis of cardiac involvement in SLE and rather rule out competing conditions. These data support the need for diagnostic methods with high sensitivity and specificity for SLE heart disease.