bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated serum levels of checkpoint molecules in patients with adult Still’s disease
Authors: Fujita Yuya , Asano Tomoyuki , Matsumoto Haruki , Matsuoka Naoki , Temmoku Jumpei , Sato Shuzo , Furuya Makiko Yashiro , Suzuki Eiji , Watanabe Hiroshi , Koga Tomohiro , Kawakami Atsushi , Migita Kiyoshi 
Published: July 2020

Abstract
Background
The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin, and mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce the inhibitory signaling to regulate immune responses. The dysregulated expression of checkpoint molecules has been reported under various inflammatory or autoimmune conditions. The aim of this study is to investigate the levels of these checkpoint molecules and their associations between proinflammatory markers in patients with adult Still’s disease (ASD).

Methods
Serum samples were collected from 47 patients with active ASD, 116 patients with rheumatoid arthritis (RA), and 37 healthy controls (HCs). Serum levels of Gal-9, soluble TIM-3 (sTIM-3), and IL-18 were determined using enzyme-linked immunosorbent assay (ELISA). Results were compared with the clinical features of ASD.

Results
Serum Gal-9 levels in patients with ASD (median: 21.57 ng/ml, interquartile range IQR [11.41–39.72]) were significantly higher compared to those in patients with RA (7.58 ng/ml, IQR [5.57–10.20] p < 0.001) as well as those in HCs (4.51 ng/ml, [IQR; 3.58–5.45], p < 0.001). Similarly, serum sTIM-3 levels in patients with ASD were significantly higher than those in patients with RA and HCs. Serum levels of Gal-9 or sTIM-3 showed positive correlations with IL-18 levels (Gal-9; r = 0.90, p < 0.001, sTIM-3; r = 0.78, p < 0.001) in patients with ASD. Serum levels of Gal-9 or sTIM-3 correlated with serum ferritin (Gal-9; r = 0.77, p < 0.001, sTIM-3; r = 0.71, p < 0.001) and ASD disease activity score (Pouchot’s score, Gal-9; r = 0.66, p < 0.001, sTIM-3; r = 0.59, p < 0.001), whereas there was no significant correlation between serum Gal-9 or sTIM-3 and CRP. ASD patients with chronic arthritis phenotype had a significantly higher Gal-9/ferritin and sTIM-3/ferritin ratio than those without this phenotype. After immunosuppressive treatment, Gal-9 and sTIM-3 levels showed a significant decline in parallel to the disease activity scores.

Conclusions
Serum levels of the coinhibitory checkpoint molecules were elevated and correlated with disease activity in patients with ASD. These coinhibitory checkpoint molecules may be implicated in the autoinflammatory process seen in ASD.
Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort
Authors: Ichinose Kunihiro , Kitamura Mineaki , Sato Shuntaro , Fujikawa Keita , Horai Yoshiro , Matsuoka Naoki , Tsuboi Masahiko , Nonaka Fumiaki , Shimizu Toshimasa , Sumiyoshi Remi , Koga Tomohiro , Kawashiri Shin-ya , Iwamoto Naoki , Igawa Takashi , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Nishino Tomoya , Kawakami Atsushi 
Published: July 2020

Abstract
Background
Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5 years of their SLE diagnosis, although it is not uncommon for LN to develop at later time points. Here we evaluated the clinical features of early- and late-onset LN.

Patients and methods
We retrospectively analyzed the cases of 184 of the 201 patients who underwent a renal biopsy at Nagasaki University Hospital and associated community hospitals between 1990 and 2016 and were diagnosed as having LN. Early onset was defined as the development of LN within the first 5 years after the patient’s SLE diagnosis, and late onset was defined as LN development > 5 years post-diagnosis. We analyzed the complete renal response (CR) at 6 and 12 months after induction therapy, the classification of renal pathology, and the mortality of the early- and late-onset LN groups.

Results
The mean follow-up duration after the renal biopsy was 123 ± 85 months. There were 113 (61.4%) early-onset patients and 71 (38.6%) late-onset patients. A multivariate analysis revealed that the following factors were predictive of CR: at 6 months: female sex (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.31–11.77, p = 0.010), proteinuria (OR 0.83, 95% CI 0.71–0.97, p = 0.009), index of activity (0–24) (OR 0.83, 95% CI 0.70–0.99, p = 0.030), and early-onset LN (OR 2.39, 95% CI 1.15–4.98, p = 0.018); at 12 months: female sex (OR 3.60, 95% CI 1.32–9.83, p = 0.013), mixed LN (OR 0.18, 95% CI 0.04–0.80, p = 0.024), index of activity (0–24) (OR 0.80, 95% CI 0.68–0.94, p = 0.007), and early-onset LN (OR 2.10, 95% CI 1.05–4.23, p = 0.035). In a Cox proportional hazards and Fine-Gray regression model, the early-onset LN group had a significantly better mortality rate than the late-onset LN group (p = 0.038 and p = 0.043, respectively).

Conclusions
In our cohort, early-onset LN was a better predictor of CR at 6 and 12 months than late-onset LN. Our results suggest that early-onset LN patients had lower mortality than late-onset LN patients.
The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
Authors: Winarno G. N. A. , Hidayat Y. M. , Soetopo S. , Krisnadi S. R. , Tobing M. D. L. , Rauf S. 
Published: July 2020

Abstract
Objective
Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery for epithelial ovarian cancer (EOC).

Results
The average values of serum CA-125, FASN, and GLS in the suboptimal cytoreduction group were higher than those in optimal cytoreduction group. The cut off point (COP) was 248.55 (p = 0.0001) with 73.2% sensitivity and 73.6% specificity for CA-125, 0.445 (p = 0.017) with 62.5% sensitivity and 60.4% specificity for FASN, and 22.895 (p = 0.0001) with 73.2% sensitivity and 75.5% specificity for GLS. The COP of CA-125 and GLS combined was 29.16 (p = 0.0001) with sensitivity 82.1% and specificity 73.6%, while the COP of CA-125, GLS, and FASN combined was 0.83 (p = 0.0001) with 87.5% sensitivity and 73.6% specificity.
Adaptive control realization for canonic Caputo fractional-order systems with actuator nonlinearity: application to mechatronic devices
Authors: Aghababa Mohammad Pourmahmood , Saif Mehrdad 
Published: July 2020

AbstractNonlinearities, such as dead-zone, backlash, hysteresis, and saturation, are common in the mechanical and mechatronic systems’ components and actuators. Hence, an effective control strategy should take into account such nonlinearities which, if unaccounted for, may cause serious response problems and might even result in system failure. Input saturation is one of the most common nonlinearities in practical control systems. So, this article introduces a novel adaptive variable structure control strategy for nonlinear Caputo fractional-order systems despite the saturating inputs. Owing to the complex nature of the fractional-order systems and lack of proper identification strategies for such systems, this research focuses on the canonic systems with complete unknown dynamics and even those with model uncertainties and external noise. Using mathematical stability theory and adaptive control strategy, a simple stable integral sliding mode control is proposed. The controller will be shown to be effective against actuator saturation as well as unknown characteristics and system uncertainties. Finally, two case studies, including a mechatronic device, are considered to illustrate the effectiveness and practicality of the proposed controller in the applications.
A mathematical model of COVID-19 using fractional derivative: outbreak in India with dynamics of transmission and control
Authors: Shaikh Amjad Salim , Shaikh Iqbal Najiroddin , Nisar Kottakkaran Sooppy 
Published: July 2020

AbstractSince the first case of 2019 novel coronavirus disease (COVID-19) detected on 30 January, 2020, in India, the number of cases rapidly increased to 3819 cases including 106 deaths as of 5 April, 2020. Taking this into account, in the present work, we have analysed a Bats–Hosts–Reservoir–People transmission fractional-order COVID-19 model for simulating the potential transmission with the thought of individual response and control measures by the government. The real data available about number of infected cases from 14 March, 2000 to 26 March, 2020 is analysed and, accordingly, various parameters of the model are estimated or fitted. The Picard successive approximation technique and Banach’s fixed point theory have been used for verification of the existence and stability criteria of the model. Further, we conduct stability analysis for both disease-free and endemic equilibrium states. On the basis of sensitivity analysis and dynamics of the threshold parameter, we estimate the effectiveness of preventive measures, predicting future outbreaks and potential control strategies of the disease using the proposed model. Numerical computations are carried out utilising the iterative Laplace transform method and comparative study of different fractional differential operators is done. The impacts of various biological parameters on transmission dynamics of COVID-19 is investigated. Finally, we illustrate the obtained results graphically.
Some modifications in conformable fractional integral inequalities
Authors: Baleanu Dumitru , Mohammed Pshtiwan Othman , Vivas-Cortez Miguel , Rangel-Oliveros Yenny 
Published: July 2020

AbstractThe prevalence of the use of integral inequalities has dramatically influenced the evolution of mathematical analysis. The use of these useful tools leads to faster advances in the presentation of fractional calculus. This article investigates the Hermite–Hadamard integral inequalities via the notion of Ϝ-convexity. After that, we introduce the notion of $\digamma _{\mu}$

Ϝ
μ

-convexity in the context of conformable operators. In view of this, we establish some Hermite–Hadamard integral inequalities (both trapezoidal and midpoint types) and some special case of those inequalities as well. Finally, we present some examples on special means of real numbers. Furthermore, we offer three plot illustrations to clarify the results.
Laplace decomposition for solving nonlinear system of fractional order partial differential equations
Authors: Khan Hassan , Shah Rasool , Kumam Poom , Baleanu Dumitru , Arif Muhammad 
Published: July 2020

AbstractIn the present article a modified decomposition method is implemented to solve systems of partial differential equations of fractional-order derivatives. The derivatives of fractional-order are expressed in terms of Caputo operator. The validity of the proposed method is analyzed through illustrative examples. The solution graphs have shown a close contact between the exact and LADM solutions. It is observed that the solutions of fractional-order problems converge towards the solution of an integer-order problem, which confirmed the reliability of the suggested technique. Due to better accuracy and straightforward implementation, the extension of the present method can be made to solve other fractional-order problems.
Comparative efficacy of hospital disinfectants against nosocomial infection pathogens
Authors: Amini Tapouk Fahim , Nabizadeh Ramin , Mirzaei Nezam , Hosseini Jazani Nima , Yousefi Mahmood , Valizade Hasanloei Mohamad Amin 
Published: July 2020

AbstractBackgroundDue to the increasing rate of hospital-acquired infections, it is essential to select appropriate disinfectant agents. In this study, the efficacy of hospital disinfectants against nosocomial infection pathogens was compared.MethodsHigh level disinfectants (Steranios 2%, Deconex HLDPA, and Microzed Quatenol) were tested for their antibacterial effects by determining their minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) againstEnterococcus faecalisATCC 29212 andBurkholderia cepaciaATCC 10673.ResultsE. faecalis, as gram-positive bacterium, was more susceptible to high level disinfectants compared to gram-negativeB.cepacia.The MIC = MBC values of 2% Steranios, Deconex HLDPA and Microzed Quatenol againstE. faecalisandB.cepaciawere 0.31, 9.77, 2.2 mg/L and 9.8, 78.13, 70.31 mg/L, respectively.ConclusionsAccording to the findings of this study, the most effective disinfectants against bothE. faecalisandB.cepaciawere Steranios 2%, Microzed Quatenol, and Deconex HLDPA in order. Considering the importance of these bacterial strains in healthcare-associated infections, the use of these effective disinfectants is recommended in the hospitals.
Family-related non-abuse adverse life experiences occurring for adults diagnosed with eating disorders: a systematic review
Authors: Grogan Katie , MacGarry Diarmuid , Bramham Jessica , Scriven Mary , Maher Caroline , Fitzgerald Amanda 
Published: July 2020

Abstract
Background
Although previous reviews suggest a strong association between abuse and eating disorders, less is known about non-abuse adverse life experiences, such as parental mental illness or family discord, which occur frequently for this population. The aim of the current study was to identify family-related non-abuse adverse life experiences occurring for adults with eating disorders, and to establish whether they occur for people with anorexia nervosa, bulimia nervosa or binge-eating disorder more than the general population and other psychiatric populations.

Method
A systematic review of studies focusing on family-related non-abuse adverse life experiences and eating disorders was conducted in accordance with PRISMA guidelines. The search string was applied to four electronic databases including Psycinfo, PubMed/Medline, CINAHL Plus and EMBASE.

Results
Of the 26 studies selected for inclusion, six types of family-related non-abuse adverse life experiences were identified: adverse parenting style; family disharmony; loss of a family member, relative or close person; familial mental health issues; family comments about eating, or shape, weight and appearance; and family disruptions. Findings provided tentative evidence for eating disorder specific (i.e. parental demands and criticism) and non-specific (i.e. familial loss and family disruptions) non-abuse adversities, with findings also suggesting that those with bulimia nervosa and binge-eating disorder were more impacted by loss, family separations and negative parent-child interactions compared to those with anorexia nervosa.

Conclusions
This review provides a clear synthesis of previous findings relating to family-related non-abuse adverse life experiences and eating disorders in adults. Implications for trauma-informed care in clinical practice were discussed (e.g. considering the impact of past life events, understanding the function of ED behaviours, reducing the risk of potential re-traumatisation).
Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874
Authors: Lin Yongtao , Zhong Lili , Li Hailun , Xu Yong , Li Xiang , Zheng Donghui 
Published: July 2020

AbstractBackgroundDiabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient ofPsoralea corylifolia Linn.(PCL), which was used to treat a number of diseases. In this study, we aimed to investigate whether psoralen could alleviate DN using in vitro model.MethodsCell viability assay and immunofluorescence were used to evaluate the effect of psoralen on high glucose (HG)-stimulated human kidney HK-2 cells (48 h). RT-qPCR was used to detect the expressions of miRNA in cells. Cell transfection, apoptosis assay, inflammatory cytokines detection and Western blot were further performed to explore the underlying molecular mechanisms.ResultsHG-induced toxicity of HK-2 cells was alleviated by psoralen. Meanwhile, the secretion of inflammatory cytokines and extracellular matrix (ECM) accumulation induced by HG in HK-2 cells were also decreased by psoralen. In addition, the expression of miR-874 in HK-2 cells was significantly upregulated by psoralen. Western blot assays indicated that psoralen could reverse HG-induced increase of TLR-4/NF-κB and Smad2 via upregulation of miR-874.ConclusionThis study demonstrated that psoralen could significantly alleviate HG-induced HK-2 cell injury via upregulation of miR-874. In addition, HG-induced increase of TLR-4/NF-κB and Smad2 was revered by psoralen. Therefore, psoralen might serve as an agent for the treatment of DN.
Analysis of liquid-type proof mass under oscillating conditions
Authors: Won Dong-Joon , Lee Sangmin , Kim Joonwon 
Published: July 2020

AbstractIn this study, the spring constant of an accelerometer with a liquid-type proof mass was analyzed. Unlike a general solid-type microelectromechanical system accelerometer, the Laplace pressure is considered a restoring force in the analyzed accelerometer. Using a base excitation mathematical model, the sensor output could be estimated for a specific spring constant. Although the estimated sensor output data fit well with the experimental results, the spring constant of the device could also be determined dynamically (for oscillations below 5 Hz). Moreover, the damping constants could be inferred depending on whether sandblasting treatment was performed. Finally, the effects of the oscillation, surface condition, and volume of liquid metal droplets on the spring constant were analyzed.
The association between low pH value and unfavorable neurological outcome among the out-of-hospital cardiac arrest patient treated by extra-corporeal CPR: sensitivity analysis
Authors: Okada Yohei , Kiguchi Takeyuki , Kitamura Tetsuhisa , Iwami Taku 
Published: July 2020

AbstractThis is the response to the comment from Dr. Romain Jouffroy and his colleague, on the manuscript “Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan”. We performed sensitivity analysis based on the comment from them. It indicated that the results of primary analysis were robust even in considering their criticism.
Monte Carlo-based scatter correction for the SMARTZOOM collimator
Authors: Dietze Martijn M. A. , Kunnen Britt , Stella Martina , de Jong Hugo W. A. M. 
Published: July 2020

Abstract
Background
Myocardial perfusion imaging is a commonly performed SPECT protocol and hence it would be beneficial if its scan duration could be shortened. For traditional gamma cameras, two developments have separately shown to allow for a shortened scan duration: (i) reconstructing with Monte Carlo-based scatter correction instead of dual-energy window scatter correction and (ii) acquiring projections with the SMARTZOOM collimator instead of a parallel-hole collimator. This study investigates which reduction in scan duration can be achieved when both methods are combined in a single system.

Results
The SMARTZOOM collimator was implemented in a Monte Carlo-based reconstruction package and the implementation was validated through image quality phantom experiments. The potential for scan duration reduction was evaluated with a phantom configuration that is realistic for myocardial perfusion imaging. The original reconstruction quality was achieved in 76 ± 8% of the original scan duration when switching from dual-energy window scatter correction to Monte Carlo-based scatter correction. The original reconstruction quality was achieved in 56 ± 13% of the original scan duration when switching from the parallel-hole to the SMARTZOOM collimator. After combining both methods in a single system, the original reconstruction quality was achieved in 34 ± 7% of the original scan duration.

Conclusions
Monte Carlo-based scatter correction combined with the SMARTZOOM collimator can further decrease the scan duration in myocardial perfusion imaging.
Engaging indigenous patient partners in patient-oriented research: lessons from a one-year initiative
Authors: Tremblay Marie-Claude , Bradette-Laplante Maude , Bérubé Danielle , Brière Élaine , Moisan Nicole , Niquay Daniel , Dogba Maman-Joyce , Légaré France , McComber Alex , McGavock Jonathan , Witteman Holly O. 
Published: July 2020

Abstract
Background
Patient-oriented research (POR) is a specific application of participatory research that promotes active patient engagement in health research. There is a growing concern that people involved in POR do not reflect the diversity of the population such research aims to serve, but are rather those more ‘easily’ engaged with institutions, organizations and society. Indigenous peoples are among such groups generally underrepresented in POR. The “Indigenous patient partners platform project” was a small-scale initiative aimed to address the issue of the underrepresentation of Indigenous people in patient-oriented research by recruiting, orienting and supporting Indigenous patient partners in Québec (Canada). This article reports on the findings of an evaluation conducted at the end of the project to garner lessons and identify strategies for engaging Indigenous patient partners in patient-oriented research.

Methods
The evaluation of this initiative used a case study design hinging on documentary analysis and committee member interviews. Project documents (n = 29) included agendas and meeting minutes, support documents from the orientation workshop and workshop evaluations, and tools the committee developed as part of the project. Interview participants (n = 6) were patients and organizational partners. Thematic analysis was performed by two members of the research team. Patient partners actively contributed to validating the interpretation of result and knowledge translation.

Results
Results point to four key components of Indigenous patient partner engagement in POR: initiation of partnership, interest development, capacity building and involvement in research. Specific lessons emphasize the importance of community connections in recruiting, sustaining and motivating patient partners, the need to be flexible in the engagement process, and the importance of consistently valuing patient partner contributions and involvement.

Conclusions
There is a need to engage Indigenous patient partners in POR to ensure that healthcare practices, policies and research take their particular needs, stories and culture into account. While results of this evaluation are generally consistent with the existing literature on patient engagement, they offer additional insight into how to effectively engage Indigenous patient partners in research, which might also be relevant to the involvement of other marginalized populations who have been historically and systemically disempowered.