bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression
Authors: Zhu Jialei , Tang Jing 
Published: July 2020

Abstract
Postpartum depression (PPD) is a kind of mental disorder characterized by persistent low emotions in puerperium. The most significant physiological change in postpartum is lactation which is regulated by oxytocin receptor (OXTR). However, whether OXTR is related to pathological process of PPD and the potential mechanism still remain unclear. In the present study, we prepared hormone-simulated pregnancy (HSP)-induced PPD mouse model and found that the protein level of OXTR in hippocampus of PPD model mice was down-regulated and Nod-like receptor protein 3 (NLRP3) inflammasome was activated. We identified five long non-coding RNAs (lncRNAs) related to PPD by transcriptome sequencing, including three up-regulated and two down-regulated. The five lncRNAs were associated with the signaling pathway of OXTR according to the bioinformatics analysis. Furthermore, we focused on one of the five lncRNAs, Gm14205, and found that it targeted OXTR which inhibited astrocytic NLRP3 inflammasome activation in hippocampal primary astrocytes. These findings illustrate that OXTR has protective effects in PPD by inhibiting NLRP3 inflammasome activation and provides a new strategy for targeting lncRNA Gm14205 in the pathogenesis of PPD.
Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function
Authors: Zou Zhi-Guo , Rios Francisco J. , Neves Karla B. , Alves-Lopes Rheure , Ling Jiayue , Baillie George S. , Gao Xing , Fuller William , Camargo Livia L. , Gudermann Thomas , Chubanov Vladimir , Montezano Augusto C. , Touyz Rhian M. 
Published: July 2020

Abstract
Objective: Transient receptor potential (TRP) melastatin 7 (TRPM7) cation channel, a dual-function ion channel/protein kinase, regulates vascular smooth muscle cell (VSMC) Mg2+ homeostasis and mitogenic signaling. Mechanisms regulating vascular growth effects of TRPM7 are unclear, but epidermal growth factor (EGF) may be important because it is a magnesiotropic hormone involved in cellular Mg2+ regulation and VSMC proliferation. Here we sought to determine whether TRPM7 is a downstream target of EGF in VSMCs and if EGF receptor (EGFR) through TRPM7 influences VSMC function.
Approach and results: Studies were performed in primary culture VSMCs from rats and humans and vascular tissue from mice deficient in TRPM7 (TRPM7+/Δkinase and TRPM7R/R). EGF increased expression and phosphorylation of TRPM7 and stimulated Mg2+ influx in VSMCs, responses that were attenuated by gefitinib (EGFR inhibitor) and NS8593 (TRPM7 inhibitor). Co-immunoprecipitation (IP) studies, proximity ligation assay (PLA) and live-cell imaging demonstrated interaction of EGFR and TRPM7, which was enhanced by EGF. PP2 (c-Src inhibitor) decreased EGF-induced TRPM7 activation and prevented EGFR–TRPM7 association. EGF-stimulated migration and proliferation of VSMCs were inhibited by gefitinib, PP2, NS8593 and PD98059 (ERK1/2 inhibitor). Phosphorylation of EGFR and ERK1/2 was reduced in VSMCs from TRPM7+/Δkinase mice, which exhibited reduced aortic wall thickness and decreased expression of PCNA and Notch 3, findings recapitulated in TRPM7R/R mice.
Conclusions: We show that EGFR directly interacts with TRPM7 through c-Src-dependent processes. Functionally these phenomena regulate [Mg2+]i homeostasis, ERK1/2 signaling and VSMC function. Our findings define a novel signaling cascade linking EGF/EGFR and TRPM7, important in vascular homeostasis.
LeNet‐5 improvement based on FPGA acceleration
Authors: Hou Yong , Chen Zhang Bao 
Published: July 2020

Deep learning is a branch of traditional machine learning. Thanks to the leap in computer hardware computing power in recent years, deep learning has become one of the hot topics. In view of the inefficiency of the traditional LeNet‐5, here, LeNet‐5 is improved by using the FPGA to accelerate the LeNet‐5. Finally, by training the handwritten digit recognition model experiment, it is verified that the improved LeNet‐5 model has a great improvement in terms of efficiency and accuracy.
Dynamical signatures of Rossby vortices in cavity-hosting disks
Authors: Robert C. M. T. , Méheut H. , Ménard F. 
Published: July 2020

Context. Planets are formed amidst young circumstellar disks of gas and dust. The latter is traced by thermal radiation, where strong asymmetric clumps have been observed in a handful of cases. These dust traps could be key to understanding the early stages of planet formation, when solids grow from micron-size to planetesimals.
Aims. Vortices are among the few known asymmetric dust trapping scenarios. The present work aims to predict their characteristics in a complementary observable. Namely, line-of-sight velocities are well suited to trace the presence of a vortex. Moreover, the dynamics of disks is subject to recent developments.
Methods. Two-dimensional hydro simulations were performed in which a vortex forms at the edge of a gas-depleted region. We derived idealized line-of-sight velocity maps, varying disk temperature and orientation relative to the observer. The signal of interest, as a small perturbation to the dominant axisymmetric component in velocity, may be isolated in observational data using a proxy for the dominant quasi-Keplerian velocity. We propose that the velocity curve on the observational major axis be such a proxy.
Results. Applying our method to the disk around HD 142527 as a study case, we predict that line-of-sight velocities are barely detectable by currently available facilities, depending on disk temperature. We show that corresponding spirals patterns can also be detected with similar spectral resolutions, which will help to test against alternative explanations.
Studying star-forming processes at core and clump scales: the case of the young stellar object G29.862−0.0044
Authors: Areal M. B. , Paron S. , Fariña C. , Ortega M. E. , Celis Peña M. , Rubio M. 
Published: July 2020

Aims. To advance our knowledge of star formation, in addition to statistical studies and large surveys of young stellar objects (YSOs), it is important to carry out detailed studies towards particular objects. Given that massive molecular clumps fragment into cores where star formation takes place, these kinds of studies should be done on different spatial scales. The aim of this work is to investigate the star-forming processes at core and clump scales.
Methods. Using near-infrared (NIR) data obtained with NIRI at the Gemini-North telescope, data of the complex molecular species CH3OCHO and CH3CN obtained from the Atacama Large Millimeter Array (ALMA) database, observations of HCN, HNC, HCO+, and C2H carried out with the Atacama Submillimeter Telescope Experiment (ASTE), and CO data from public surveys observed with the James Clerck Maxwell Telescope (JCMT), we perform a deep study of the YSO G29.862−0.0044 (YSO-G29) at core and clump spatial scales.
Results. The NIR emission shows that YSO-G29 is composed of two nebulosities separated by a dark lane, suggesting a scenario consistent with a typical disc plus jets system, albeit in this case highly asymmetric. The northern nebulosity is open, diffuse, and is divided into two branches, while the southern one is smaller and sharper. They are likely produced by the scattered light in cavities carved out by jets or winds on an infalling envelope of material, which also presents line emission of H2 S(1) 1–0 and 2–1, and [FeII]. The presence of the complex molecular species observed with ALMA confirms that we are mapping a hot molecular core. The CH3CN emission concentrates at the position of the dark lane and appears slightly elongated from southwest to northeast in agreement with the inclination of the system as observed in the NIR. The morphology of the CH3OCHO emission is more complex and extends along some filaments and concentrates in knots and clumps, mainly southwards of the dark lane, suggesting that the southern jet is encountering a dense region. The northern jet is able to flow more freely, generating the more extended features as seen in the NIR. This is in agreement with the redshifted molecular outflow traced by the 12CO J = 3–2 line extending towards the northwest and the lack of a blueshifted outflow. This configuration can be explained by considering that G29-YSO is located at the furthest edge of the molecular clump along the line of sight, which is consistent with the position of the source in the cloud mapped in the C18O J = 3–2 line. The detection of HCN, HNC, HCO+, and C2H allowed us to characterise the dense gas at clump scales, yielding results that are in agreement with the presence of a high-mass protostellar object.
Cardiac Echocardiography in COVID-19 Infection
Authors: Kapur Rohan , Garg Naveen , Kapur K. K. , Kapoor Pranav , Kapoor Poonam Malhotra 
Published: July 2020

AbstractThe novel COVID-19 disease mainly affects respiratory organs; however, involvement of cardiovascular system is also not uncommon. Cardiac involvement can manifest as myocarditis, heart failure, myocardial infarction, pulmonary embolism, or arrhythmias in COVID-19 patients. This novel Coronavirus enters into the cells of the human body by binding to ACE-2 receptors which are predominantly present on pneumocytes and cardiomyocytes. The damage to myocardium is manifested by the increase in cardiac enzymes such as troponin-I, CK-MB, and NT pro-BNP. Although echocardiogram is an important tool in the cardiac evaluation of COVID-19 patients, its indiscriminate use is discouraged, owing to the risk of transmission to echocardiography service providers, as well as possible risk of contaminating echocardiography equipment. In this article, we discuss the different mechanisms and cardiac manifestations of COVID-19. We also review the current guidelines for echocardiography evaluation of COVID-19 patients as well as current recommendations on safety of echocardiography personnel and equipment against contamination. We also include our experience of two cases in which COVID-19 affliction of heart was strongly suspected, and echocardiography clinched the diagnosis.
Antithrombotic Therapy in Myocardial Infarction: Historic Perils and Current Challenges—A 70-Year Journey
Authors: Stub Dion , Fernando Himawan , McFadyen James D. , Palasubramaniam Jathushan , Shaw James , Wang Xiaowei , Peter Karlheinz 
Published: July 2020

AbstractThere have been numerous and intriguing advancements in antithrombotic therapy for myocardial infarction since it was described in the earliest issues of Thrombosis and Haemostasis. In this article, we revisit historical breakthroughs and describe the four most challenging contemporary themes relating to antithrombotic therapy in myocardial infarction. In all four, the challenge is to find the best balance of reducing specific levels of ischaemic risks without increasing bleeding risk. The first is the question of the optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). This includes discussion of monotherapy after a period of DAPT. The second relates to the role of genotype and phenotype-guided individualisation of antiplatelet therapy. There is emerging evidence for a role of pheno/genotyping in identifying individuals at high risk for recurrent ischaemic events or in guiding the timing of cardiac surgery for patients on DAPT. The third addresses the increasing evidence for dual pathway inhibition, for example, with rivaroxaban in addition to aspirin in patients where high ischaemic and low bleeding risk is demonstrated. Finally the fourth highlights the challenge of the most appropriate combination of antiplatelet and anticoagulation therapy for patients with known atrial fibrillation after PCI. In most individuals, oral P2Y12 inhibitor therapy combined with a direct acting oral anticoagulant appears to be the best strategy based on the available evidence. Overall, the progress in antithrombotic therapy achieved over the last seven decades is remarkable, however, there are important issues to address and progress still to be made.
Evaluation of Angiogenesis in Multiple Myeloma by VEGF Immunoexpression and Microvessel Density
Authors: Palta Anshu , Kaur Manveen , Tahlan Anita , Dimri Kislay 
Published: July 2020

Abstract
Background Multiple myeloma (MM) is a plasma cell disorder characterized by monoclonal proliferation of plasma cells in bone marrow. Plasmablastic MM is a morphologic subset of MM, containing ≥2% plasmablasts of all plasma cells.
Methods The study included 30 consecutively diagnosed patients of MM (6 plasmablastic, 24 nonplasmablastic) over a span of 2 years. Angiogenesis in MM was assessed by analysis of vascular endothelial growth factor (VEGF) immunoexpression by plasma cells and microvessel density (MVD) using anti-CD34 antibody. CD34 and VEGF immunohistochemical staining was performed in all the 30 cases. Angiogenesis was studied in relation to plasmablastic morphology and clinical profile to determine if any correlation exists between these.
Results The mean VEGF expression of 80.83 ± 7.36 in plasmablastic myeloma cases was significantly higher compared with a mean VEGF of 53.54 ±17.09 in nonplasmablastic cases. Most of the cases (66.6%) of plasmablastic myeloma exhibited strong (3+) VEGF expression. The difference in mean VEGF expression between plasmablastic and nonplasmablastic cases was found to be statistically significant (p = 0.001). The mean MVD in plasmablastic cases was 44.8 ± 3.69, while in the nonplasmablastic category, the mean MVD was 23.7 ± 5.14, difference being statistically significant (p < 0.05). Also, a positive correlation was found between VEGF expression and MVD.
Conclusion A moderate/strong VEGF intensity and higher MVD were found in cases of plasmablastic MM, suggesting that a more aggressive histological disease may be associated with increased production of VEGF. This finding might be helpful to identify a subset of patients with adverse prognosis and to provide antiangiogenic therapy to improve their survival. However, studies comprising larger number of patients are required to bring out a statistical significance to further substantiate these findings.
Optomechanical interaction in fibre lasers with micro-optomechanical resonance structures
Authors: Egorov F.A. , Potapov V.T. 
Published: July 2020

Abstract
We report the results of studies of fibre lasers with passive modulators based on light-excited micro-optomechanical resonance structures (micro-oscillators). It is shown that in fibre lasers based on active fibres doped with rare-earth elements (Er, Er/Yb, Yb, Nd), the optomechanical interaction of laser radiation with micro-oscillators of various types (fibre-optic, microvolume) leads to self-oscillations of the characteristics of laser radiation at frequencies of relaxation oscillations and intermode beats synchronised with the frequencies of elastic eigenoscillations of micro-oscillators. It is found that in an ultra-long erbium – ytterbium fibre laser with a nonlinear mirror based on a microcantilever, laser photothermal excitation of the second mode of elastic transverse oscillations of the microcantilever makes it possible to perform passive mode locking exclusively due to Q-switching of the laser cavity. Pulsed lasing with a controlled repetition rate (∼76 kHz), a pulse duration of 2 – 5 μs and an output energy of 0.1 μJ per pulse is implemented. Based on a simplified physical model of the indicated fibre lasers with micro-oscillators, we have developed an approximate mathematical model describing the regimes of passive mode locking of fibre lasers with micro-oscillators that play the role of mirrors with a nonlinear reflection coefficient in the laser cavity. The prospects for the development and application of the considered laser systems are discussed.
Effect of focused nanosecond laser pulse irradiation on microtribological properties of diamond-like films
Authors: Frolov V.D. , Pivovarov P.A. , Zavedeev E.V. , Shupegin M.L. , Pimenov S.M. 
Published: July 2020

Abstract
We have examined the effect of focused nanosecond laser pulses on the formation and tribological properties of microstructures in the form of a matrix of craters produced in a – C : H : Si : O diamond-like films (DLFs), both undoped and doped with tungsten. The studies are performed by scanning probe microscopy (SPM) using SPM probes of standard design with a tip and probes without a tip (tipless-type probes). A special procedure is developed for assessing the wettability (contact angle) of individual sections of the laser-induced microstructure by the local adhesion force. According to estimates, the material inside the crater becomes softer and more hydrophobic as a result of laser irradiation. This is manifested to the greatest extent in tungsten-doped DLFs, where the crater walls are arranged like terraces formed by ‘nanoflakes’, i.e. grains of the substance. Scanning of microstructures with a tipless probe in the regime of lateral force microscopy demonstrates a decrease in friction in the crater area.
Influence of growth temperature of KTiOAsO4 single crystals on their physicochemical parameters and formation of domain structures
Authors: Isaenko L.I. , Eliseev A.P. , Kolker D.B. , Vedenyapin V.N. , Zhurkov S.A. , Erushin E.Yu. , Kostyukova N.Yu. , Boiko A.A. , Shur V.Ya. , Akhmatkhanov A.R. , Chuvakova M.A. 
Published: July 2020

Abstract
A potassium titanyl arsenate (KTiOAsO4, KTA) crystal 50 × 80 × 60 mm in size has been grown by upgraded Czochralski method from flux (TGGS) with a decrease in temperature from 900 to 770 °C during pulling. It is shown that the spectroscopic properties of the parts of KTA crystals grown at 900 and 770 °C are close, whereas the electrical conductivity of the low-temperature (770 °C) KTA part turned out to be an order of magnitude lower than that of the high-temperature part. Visualisation of the domain structure by second-harmonic generation microscopy revealed a more efficient domain intergrowth (throughout the sample) in the low-temperature KTA, which is important for forming a regular domain structure (RDS) in a KTA-based nonlinear optical element. It is established that the quantum efficiency of parametric generation of light in the RDS formed in low-temperature KTA is several times higher than in the case of high-temperature KTA. The results obtained are important for optimising RDS parameters.
Experimental investigation of laser ablation of stone polycrystalline targets
Authors: Burdonskii I.N. , Leonov A.G. , Makarov K.N. , Yufa V.N. 
Published: July 2020

Abstract
We report the results of an experimental investigation of ablation of stone polycrystalline targets of complex multicomponent composition, which imitate the substance of asteroids. The targets were irradiated by nanosecond pulses of a neodymium laser at an energy density Φ
L of up to 5 × 104 J cm−2. The experiments demonstrated the existence of two ablation regimes, with the boundary between them lying at Φ
L ≈ 4000 J cm−2. The regime change is characterised by a change in the form of the dependence of the surface mass density of removed target material on the laser energy density and by the appearance of a minimum in the dependence of specific energy of destruction on Φ
L. This is supposedly related to the passage from a one-dimensional plasma plume expansion to the three-dimensional one and the corresponding decrease in the efficiency of energy transfer from the laser beam to the target due to a lowering of laser-produced plasma density. Our experiments also showed the existence of a maximum in impulse coupling coefficient C
m as a function of laser energy density (C
m ≈ 6.3 × 10−5 N W−1 for Φ
L = Φ
opt ≈ 25 J cm−2). Maxima were also recorded in the dependences of the ablation efficiency and average ablation flow velocity on Φ
L. For Φ
L > Φ
opt, the decrease in the function C
m(Φ
L) turns out to be much steeper than for metals and polymer materials. The difference is supposedly due to the lower strength and lower plasticity of the polycrystalline stone targets.
Leaky wave in high-power AlGaAs/InGaAs/GaAs semiconductor lasers
Authors: Bobretsova Yu.K. , Veselov D.A. , Klimov A.A. , Kryuchkov V.A. , Shashkin I.S. , Slipchenko S.O. , Pikhtin N.A. 
Published: July 2020

Abstract
Lasers based on AlGaAs/InGaAs/GaAs heterostructures operating in the spectral range of 1.0 − 1.1 μm are investigated in order to optimise cladding layers. The effect of the thickness and composition of the cladding layers on the leakage of radiation from the laser waveguide is analysed. It is shown that for cladding thicknesses of 0.86 − 1.24 μm, it almost does not affect the output optical power. The effect of the crystal length and reflectivity of the laser mirrors on the leaky wave is demonstrated.
Lasing characteristics of ZrO2 − Y2O3 − Ho2O3 crystals pumped by a Tm : LiYF4 laser
Authors: Ryabochkina P.A. , Artemov S.A. , Zakharov N.G. , Saltykov E.V. , Vorontsov K.V. , Chabushkin A.N. , Lomonova E.E. 
Published: July 2020

Abstract
Two-micron lasing is obtained on the 5I7 → 5I8 transition of Ho3+ ions in ZrO2 − Y2O3 −Ho2O3 crystals upon resonance pumping into the 5I7 level of these ions by a pulsed laser based on a Tm : LiYF4 crystal. The efficiency of conversion of pump radiation incident on the crystal to laser radiation and the slope lasing efficiency at a pulse duration of 8 ms and a pulse repetition rate of 10 Hz were 25% and 28%, respectively.
Effect of finite ion mass on relativistic self-induced transparency of plasma layers with a sharp boundary
Authors: Mikheitsev N.A. , Korzhimanov A.V. 
Published: July 2020

Abstract
We consider the effect of ion mobility on the threshold of relativistic self-induced transparency under irradiation of thin plasma layers by circularly polarised laser radiation. An analytical model of the motion of ions during the removal of electrons from the layer surface by the ponderomotive force of laser radiation is constructed. The model is used to analyse the motion of probe electrons in the resulting electromagnetic field. It is shown that the higher the ion mobility and the longer the laser pulse, the more stable the plasma layer to longitudinal perturbations of a finite value and the higher the threshold of self-induced transparency. These conclusions are verified by one-dimensional numerical simulation of a complete system of kinetic equations for plasma and Maxwell’s equations.
Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells
Authors: Alexander Helen K. , MacLean R. Craig 
Published: July 2020

SignificanceThe emergence of antibiotic resistance poses a critical threat to the efficacy of antibiotic treatments. A resistant bacterial population must originally arise from a single cell that mutates or acquires a resistance gene. This single cell may, by chance, fail to successfully reproduce before it dies, leading to loss of the nascent resistant lineage. Here, we show that antibiotic concentrations that selectively favor resistance are nonetheless sufficient to reduce the chance of outgrowth from a single cell to a very low probability. Our findings suggest that lower antibiotic concentrations than those required to clear a large resistant population may be sufficient to prevent, with high probability, outgrowth of initially rare resistant mutants.