bluuebunny/crossref_metadata_2025_split huggingface dataset:
Over 15.7% Efficiency of Ternary Organic Solar Cells by Employing Two Compatible Acceptors with Similar LUMO Levels
Authors: Hu Zhenghao , Yang Linqiang , Gao Wei , Gao Jinhua , Xu Chunyu , Zhang Xiaoli , Wang Zhi , Tang Weihua , Yang Chuluo , Zhang Fujun 
Published: April 2020

AbstractEfficient organic solar cells (OSCs) are fabricated using polymer PM6 as donor, and IPTBO‐4Cl and MF1 as acceptors. The power conversion efficiency (PCE) of IPTBO‐4Cl based and MF1 based binary OSCs individually arrive to 14.94% and 12.07%, exhibiting markedly different short circuit current density (JSC) of 23.18 mA cm−2 versus 17.01 mA cm−2, fill factor (FF) of 72.17% versus 78.18% and similar open circuit voltage (VOC) of 0.893 V versus 0.908 V. The two acceptors, IPTBO‐4Cl and MF1, have similar lowest unoccupied molecular orbital levels, which is beneficial for efficient electron transport in the ternary active layer. The PCE of optimized ternary OSCs arrives to 15.74% by incorporating 30 wt% MF1 in acceptors, resulting from the simultaneously increased JSC of 23.20 mA cm−2, VOC of 0.897 V, and FF of 75.64% in comparison with IPTBO‐4Cl based binary OSCs. The gradually increased FFs of ternary OSCs indicate the well‐optimized phase separation and molecular arrangement with MF1 as morphology regulator. This work may provide a new viewpoint for selecting an appropriate third component to achieve efficient ternary OSCs from materials and photovoltaic parameters of two binary OSCs.
A semantic and social‐based collaborative recommendation of friends in social networks
Authors: Berkani Lamia 
Published: April 2020

SummaryThe development of social media technologies has greatly enhanced social interactions. The proliferation of social platforms has generated massive amounts of data and a considerable number of persons join these platforms every day. Therefore, one of the current issues is to facilitate the search for the most appropriate friends for a given user. We focus in this article on the recommendation of users in social networks. We propose a novel approach which combines a user‐based collaborative filtering (CF) algorithm with semantic and social recommendations. The semantic dimension suggests the close friends based on the calculation of the similarity between the active user and his friends. The social dimension is based on some social‐behavior metrics such as friendship and credibility degree. The novelty of our approach concerns the modeling of the credibility of the user, through his/her trust and commitment in the social network. A social recommender system based on this approach is developed and experiments have been conducted using the Yelp social network. The evaluation results demonstrated that the proposed hybrid approach improves the accuracy of the recommendation compared with the user‐based CF algorithm and solves the sparsity and cold start problems.
Probabilistic structural analysis of São João Bridge based on the on‐site study of the time‐dependent behavior of concrete
Authors: Santos Luis O. , Xu Min , Virtuoso Francisco 
Published: April 2020

AbstractThis article aims to present a procedure to take into account the variability of the time‐dependent behavior of concrete on its structural effects, evaluated from the study of creep and shrinkage based on experimental data obtained on‐site. For this purpose, the São João Bridge, a railway bridge built in Porto, Portugal in 1991, is presented as a case study. São João Bridge is a railway bridge crossing the river Douro. It is a prestressed concrete structure, with a total length of 1,028 m, including the main span of 250 m, two side spans of 125 m, six approaching spans on the left river bank, and three approaching spans on the right river bank (Porto). During bridge construction, a comprehensive structural health monitoring (SHM) system was set up, as well as an on‐site study of time‐dependent behavior of concrete. This study was based on creep 15 specimens and 15 shrinkage specimens, prepared simultaneously with some segments of the deck, using the same material, and it was kept running during almost 20 years. The results of this study were treated statistically and used as random variables in a probabilistic analysis of the time‐dependent behavior of the bridge. After a brief description of the mentioned on‐site study and the bridge SHM system, the paper presents the procedure followed on the bridge numerical probabilistic analysis. Finally, the values computed by the numerical model are presented and compared with the experimental values provided by the SHM.
Sulfuric acid resistance of alkali/slag activated silico‐manganese fume‐based mortars
Authors: Nasir Muhammad , Megat Johari Megat Azmi , Maslehuddin Mohammed , Yusuf Moruf Olalekan 
Published: April 2020

AbstractThe resistance of alkaline‐activated silico‐manganese fume (SMF) and blast furnace slag (BSF)‐based mortar, prepared by varying BFS and NaOHaq composition, during 20 weeks of exposure to 5% sulfuric acid (H2SO4aq) of initial pH = 0.24 and pure water (controlled) was studied. The deterioration was monitored by visual, alkalinity, mass, compressive strength and microstructural tests. The set of specimens synthesized included: (a) BFS‐free high alkaline, (b) SMF‐BFS blended high alkaline, and (c) SMF‐BFS blended mild alkaline system. Their residual strengths after 20 weeks of acid exposure were 20.1, 18.6, and 16%, respectively. BFS‐free specimens exhibited high resistance to acid attack due to the dearth of Ca in SMF. BFS‐admixed mild alkali system resulted formation of more gypsum and dealumination attributed to incomplete dissolution of Ca grains leading to severe spalling. BFS‐admixed high alkaline system underwent moderate resistance due to dense microstructure formed by additional C‐S‐H, K‐A‐S‐H, and C‐Mn‐H gel which enhanced retention of the polymerized framework.
The paradox of opposite directions of gene expressions in MCI and AD suggests possible therapy to prevent progression of MCI to AD
Authors: Fessel Jeffrey 
Published: April 2020

AbstractOne of the puzzling observations concerning mild cognitive impairment (MCI) and Alzheimer's disease (AD), is that many gene expressions in MCI may be in the opposite direction of those seen in AD. Several examples of this paradox are provided. The likely explanation lies in in the control mechanisms of gene transcription. These mechanisms include (1) modification of DNA and histones by methylation or acetylation, affecting the balance between the Compass group of proteins that enhances mRNA formation, and the Polycomb group that suppresses it; (2) compensation for the loss of one gene's function by another gene with overlapping functions; (3) reduced control of the entire neural RNA production; and (4) response to microRNAs (miRNA). Although data are inadequate to exclude with certainty any one of the indicated mechanisms, the available evidence favors overall reduced control of neural mRNA production, including the effect of miRNA. The switch occurs at a specific stage, somewhere between Braak 0‐1 and Braak 2‐3, in the progression from MCI to AD, which reduces the number of its likely causes. Two strong but related candidates are the repressor element‐1 silencing transcription factor (REST), which in adult neurons impairs plasticity; and a miRNA, for example, miRNA124, that represses REST. Another possible explanation is that only those patients with MCI who will not progress to AD are the ones that have gene expressions in the opposite direction as in AD. The solution to the paradox may have pragmatic value.
In silico toxicology: From structure–activity relationships towards deep learning and adverse outcome pathways
Authors: Hemmerich Jennifer , Ecker Gerhard F. 
Published: April 2020

AbstractIn silico toxicology is an emerging field. It gains increasing importance as research is aiming to decrease the use of animal experiments as suggested in the 3R principles by Russell and Burch. In silico toxicology is a means to identify hazards of compounds before synthesis, and thus in very early stages of drug development. For chemical industries, as well as regulatory agencies it can aid in gap‐filling and guide risk minimization strategies. Techniques such as structural alerts, read‐across, quantitative structure–activity relationship, machine learning, and deep learning allow to use in silico toxicology in many cases, some even when data is scarce. Especially the concept of adverse outcome pathways puts all techniques into a broader context and can elucidate predictions by mechanistic insights.This article is categorized under:
Structure and Mechanism > Computational Biochemistry and Biophysics
Data Science > Chemoinformatics
Effects of inflow turbulence intensity and turbine arrangements on the power generation efficiency of large wind farms
Authors: Wu Yu‐Ting , Lin Chuan‐Yao , Chang Tsang‐Jung 
Published: April 2020

AbstractIn this study, we conduct a series of large‐eddy simulations (LESs) to study the impact of different incoming turbulent boundary layer flows over large wind farms, with a particular focus on the overall efficiency of electricity production and the evolution of the turbine wake structure. Five representative turbine placements in the large wind farm are considered, including an aligned layout and four staggered layouts with lateral or vertical offset arrangements. Four incoming flow conditions are used and arranged from the LESs of the ABL flow over homogeneous flat surfaces with four different aerodynamic roughness lengths (i.e., z0 = 0.5, 0.1, 0.01, and 0.0001 m), where the hub‐height turbulence intensity levels are about 11.1%, 8.9%, 6.8%, and 4.9%, respectively. The simulation results indicate that an enhancement in the inflow turbulence level can effectively increase the power generation efficiency in the large wind farms, with about 23.3% increment on the overall farm power production and up to about 32.0% increment on the downstream turbine power production. Under the same inflow condition, the change of the turbine‐array layouts can increase power outputs within the first 10 turbine rows, which has a maximum increment of about 26.5% under the inflow condition with low turbulence. By comparison, the increase of the inflow turbulence intensity facilitates faster wake recovery that raises the power generation efficiency of large wind farms than the adjustment of the turbine placing layouts.
Homöopathie: Heilslehre „ohne Substanz“
Authors: Schmacke Norbert 
Published: April 2020

ZusammenfassungDie Homöopathie gehört in Deutschland zu den häufig angewendeten alternativen Heilmethoden. In diesem Diskussionsbeitrag soll erörtert und analysiert werden, warum die Homöopathie nicht zur Medizin gehören sollte und vielmehr als Glaubenskonzept zu verstehen ist, das außerhalb wissenschaftlicher Methoden angesiedelt ist. Erläutert werden die klinischen, rechtlichen und politischen Dimensionen der Homöopathiedebatte. Schließlich wird die Frage der Legitimität von Placeboanwendungen im Lichte der Forderung nach patientenzentrierter Medizin diskutiert.
Termite resistance of pine wood treated with nano metal fluorides
Authors: Usmani Shirin M. , Plarre Rudy , Hübert Thomas , Kemnitz Erhard 
Published: April 2020

AbstractFluorides are well-known as wood preservatives. One of the limitations of fluoride-based wood preservatives is their high leachability. Alternative to current fluoride salts such as NaF used in wood protection are low water-soluble fluorides. However, impregnation of low water-soluble fluorides into wood poses a challenge. To address this challenge, low water-soluble fluorides like calcium fluoride (CaF2) and magnesium fluoride (MgF2) were synthesized as nanoparticles via the fluorolytic sol−gel synthesis and then impregnated into wood specimens. In this study, the toxicity of nano metal fluorides was assessed by termite mortality, mass loss and visual analysis of treated specimens after eight weeks of exposure to termites, Coptotermes formosanus. Nano metal fluorides with sol concentrations of 0.5 M and higher were found to be effective against termites resulting in 100% termite mortality and significantly inhibited termite feeding. Among the formulations tested, the least damage was found for specimens treated with combinations of CaF2 and MgF2 with an average mass loss less than 1% and visual rating of “1”. These results demonstrate the efficacy of low water-soluble nano metal fluorides to protect wood from termite attack.
Influence of malt modification and the corresponding macromolecular profile on palate fullness in cereal-based beverages
Authors: Krebs Georg , Becker Thomas , Gastl Martina 
Published: April 2020

AbstractThe sensory attribute palate fullness of cereal-based beverages was shown to be affected by polymeric compounds and their macromolecular profile. During malting, the enzymatic degradation of polymers is technologically controlled by the malting parameters, namely the degree of steeping, germination time, and germination temperature. The macromolecular profile of a fermented cereal-based beverage consists of non-fermentable substance classes. Therefore, the macromolecular composition of a final beverage is originally dominated by the raw material, if conventional production methods are used. We investigated the influence of different cytolytic and proteolytic malt modifications on the macromolecular profile of lactic acid-fermented cereal-based beverages (a strain was selected that did not produce exopolysaccharides) and their resultant effect on the sensory perception of the attributes of palate fullness and mouthfeel. Asymmetrical-flow field-flow fractionation coupled with multi-angle light-scattering detection and refractive index detection is an analytical tool for macromolecular characterization to indicate differences in the macromolecular profile, molar mass, and molar mass distribution. The beverages produced using different modified malts demonstrated a considerable variation in their final composition, particularly in the composition of their macromolecular compounds. A higher level of malt modification led to a decrease in the high-molar-mass fraction and a consequent shift toward fractions with a lower molar mass. Malts produced from barley with increased crude protein contents resulted in a greater range within the macromolecular profile. The variation of germination time significantly influenced the number average molar mass, the total refractive index detection (dRI) peak area, and the high-molar-mass fraction, which contained cell wall polysaccharides (60–1200 kDa). The perception of the intensity of palate fullness was significantly correlated with specific macromolecular fractions, which were influenced by the malting parameter degree of steeping and the resultant modification. The perception of the mouthfeel descriptor watery varied significantly for different crude protein contents. Our results are beneficial for a targeted design of beverage composition based on the macromolecular profile by an improved selection of raw materials and malting technology.
The Role of the Depressor Nasi Septi Muscle in Nasal Air Flow
Authors: Seyed Resuli Ali , Oktem Fatih , Ataus Sureyya 
Published: April 2020

Abstract
Background
Musculus depressor septi nasi and its tendon, the dermocartilaginous ligament, play an important role in external nasal valve and nasal respiration. If the ligament is cut during septorhinoplasty operations, nasal functions of the nose and facial expressions are affected. Therefore, the aim of this study was to investigate the role of M. depressor septi nasi in nasal respiration at open rhinoplasty operations using rhinomanometry and electromyography.

Methods
The study included 29 patients who had only external nasal deformity (nasal hump deformity). All patients underwent open rhinoplasty. The dermocartilaginous ligament of the patients in the study group (DCL + group) was repaired but not in the control group (DCL − group). Rhinomanometry and electromyography were applied to all patients preoperatively and postoperatively.

Results
In the DCL − group, right and left nasal airflow values were significantly lower in post-op (562.92 cm3/s and 548.57 cm3/s), whereas right, left, and total nasal resistances were significantly lower in pre-op (0.28 Pa/cm3/s, 0.22 Pa/cm3/s, and 0.11 Pa/cm3/s). Statistically significant differences were not found between rhinomanometric measurements in pre-op and post-op values of the DCL + group. Post-op right, left and mean values of M. depressor septi nasi amplitude in the DCL + group (2.05 mV, 2.0 mV, 2.02 mV) were significantly higher than those in the DCL − group (1.52 mV, 1.61 mV, 1.57 mV).

Conclusion
Repair of the dermocartilaginous ligament during open rhinoplasty operations enhances nasal respiratory functions by expanding the external nasal valve through M. depressor septi nasi and allows the nose to participate in mimic movements.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
An Update on Foley Catheter Balloon Tamponade for Penetrating Neck Injuries
Authors: Scriba Matthias , McPherson Deidre , Edu Sorin , Nicol Andrew , Navsaria Pradeep 
Published: April 2020

AbstractBackgroundFoley catheter balloon tamponade (FCBT) for bleeding penetrating neck injuries (PNIs) is effective. This study aims to audit the technique and outcomes of FCBT.MethodsAdult patients with PNIs requiring FCBT presenting to Groote Schuur Hospital (GSH) within a 22‐month study period were prospectively captured on an approved electronic registry. Retrospective analysis included demographics, major injuries, investigations, management and outcomes.ResultsDuring the study period, 628 patients with PNI were treated at GSH. In 95 patients (15.2%), FCBT was utilised. The majority were men (98%) with an average age of 27.9 years. Most injuries were caused by stab wounds (90.5%). The majority of catheters (81.1%) were inserted prior to arrival at GSH. Computerised tomographic angiography (CTA) was done in 92.6% of patients, while eight patients (8.4%) required catheter‐directed angiography. Six were performed for interventional endovascular management. Thirty‐four arterial injuries were identified in 29 patients. Ongoing bleeding was noted in three patients, equating to a 97% success rate for haemorrhage control. Thirteen (13.7%) patients required neck exploration. Seventy‐two (75.8%) patients without major arterial injury had removal of the catheter at 48–72 h. Two of these bled on catheter removal. A total of 36 complications were documented in 28 patients (29.5%). There was one death due to uncontrolled haemorrhage from the neck wound.ConclusionThis large series highlights the ease of use of FCBT with high rates of success at haemorrhage control (97%). Venous injuries and minor arterial injuries are definitively managed with this technique.
Simultaneous optical measurement of temperature and velocity fields in solidifying liquids
Authors: Anders S. , Noto D. , Tasaka Y. , Eckert S. 
Published: April 2020

Abstract
We introduce a complex image processing scheme for the simultaneous application of liquid crystal thermometry (LCT), in addition to the previously established method in Anders et al. (Exp Fluids 60(4):68, 2019. 10.1007/s00348-019-2703-8) for particle tracking velocimetry and particle image velocimetry. This scheme was developed for an experimental study on the double-diffusive convection in an aqueous ammonium chloride solution NH4Cl(aq) during crystallization. The use of thermochromic liquid crystals (TLC) enables to visualize the flow and temperature field simultaneously. We present a color interpolation method that enhances the accuracy of the LCT by yielding RGB images only representative of the TLC’s coloration. An artificial neural network (ANN) which processes RGB triplets and spatial color dependencies transforms these images into temperature fields. The combination of the ANN system and a corresponding calibration procedure enhances the accuracy and measurable temperature range of the LCT compared to state-of-the-art procedures. By using the here established measurement scheme, quantitative global studies of the mutual influence between solidification and convection are enabled and exemplary results are presented.

Graphic abstract
Caffeine content in newborn hair correlates with maternal dietary intake
Authors: Lehtonen Anni , Uusitalo Lauri , Auriola Seppo , Backman Katri , Heinonen Seppo , Keski-Nisula Leea , Pasanen Markku , Pekkanen Juha , Tuomainen Tomi-Pekka , Voutilainen Raimo , Hantunen Sari , Lehtonen Marko 
Published: April 2020

Abstract
Purpose
High-maternal caffeine intake during pregnancy may be harmful for perinatal outcomes and future child health, but the level of fetal cumulative exposure has been difficult to measure thus far. Here, we present maternal dietary caffeine intake during the last trimester and its correlation to caffeine content in newborn hair after birth.

Methods
Maternal third trimester diets and dietary caffeine intake were prospectively collected in Kuopio Birth Cohort (KuBiCo) using a 160-item food frequency questionnaire (n = 2840). Newborn hair was collected within 48 h after birth and analyzed by high-resolution mass spectrometry (HRMS) for caffeine (n = 316). Correlation between dietary caffeine intake and neonatal hair caffeine content was evaluated from 203 mother–child pairs.

Results
Mean dietary caffeine intake was 167 mg/days (95% CI 162–172 mg/days), of which coffee comprised 81%. Caffeine in the maternal diet and caffeine content in newborn hair correlated significantly (r = 0.50; p < 0.001). Older, multiparous, overweight women, and smokers had the highest caffeine levels in the maternal diet, as well as in their newborn babies’ hair.

Conclusion
Caffeine exposure, estimated from newborn hair samples, reflects maternal third trimester dietary caffeine intake and introduces a new method to assess fetal cumulative caffeine exposure. Further studies to evaluate the effects of caffeine exposure on both perinatal and postnatal outcomes are warranted, since over 40% of pregnant women consume caffeine more than the current suggested recommendations (European Food Safety Association, EFSA recommendations).