bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual orientation disparities in food insecurity and food assistance resource use in U.S. adult women: National Health and Nutrition Examination Survey, 2005-2014
Authors: Patterson Joanne G , Russomanno Jennifer , Tree Jennifer M Jabson 
Published: June 2020

Abstract

Background. Nearly 40 million American adults report past year food insecurity. This is concerning, as food insecurity is associated with chronic disease morbidity and premature mortality. Women disproportionately experience food insecurity, and sexual minority women (i.e., lesbian, bisexual, and heterosexual women reporting same-sex behavior; SMW) may be at greater risk for experiencing food insecurity disparities. The purpose of this study was to investigate patterns and prevalence of food insecurity and food assistance use in sexual minority and exclusively heterosexual women using population-level health surveillance data. Methods. Using pooled 2004-2014 National Health and Nutrition Examination Survey data (N = 7379), we estimated weighted point prevalence of past 12-month food insecurity, severe food insecurity, Supplemental Nutrition Assistance Program (SNAP) use, and emergency food assistance use. We then used Poisson regression with robust variance to estimate prevalence ratios comparing SMW to exclusively heterosexual women on all outcomes. Women were classified by sexual identity and lifetime same-sex behavior as lesbian (n =88), bisexual (n = 251), heterosexual and reporting same-sex behavior (heterosexual WSW; n = 366), or exclusively heterosexual women (referent; n = 6674). Results. Between 20.6-25.5% of lesbian, bisexual, and heterosexual WSW reported past 12-month food insecurity (versus 13.1% of exclusively heterosexual women). All SMW reported greater prevalence of past 12-month food insecurity and severe food insecurity than exclusively heterosexual women: prevalence ratios (PR) ranged from 1.34 (95% confidence interval [CI], 1.05-1.70) to 1.84 (95% CI, 1.13-3.01). No differences were found in SNAP participation by sexual orientation, but more lesbians and heterosexual WSW reported using emergency food assistance in the past 12-months (PR = 1.89; 95% CI, 1.29-2.79 and PR = 1.43; 95% CI, 1.03-2.00 respectively). Conclusions. All SMW reported higher prevalence of food insecurity than exclusively heterosexual women. Lesbians and heterosexual WSW were also more likely to rely on emergency food assistance. This is problematic as SNAP use may reduce food insecurity over time, but emergency food resources (e.g., food pantries) do not. More evidence is needed to understand the multilevel factors driving food insecurity in this population to develop policy and community-based efforts to increase SNAP participation and decrease food insecurity.
Factors influencing happiness in the elderly based on the Anderson model
Authors: Zhang Xueying , Huang Shuang , Jing Lijia , Liu Zongzhuang , Wang Xin , Li Li 
Published: June 2020

Abstract
Background: The happiness of elderly people is an important indicator of successful aging. Research shows that happiness among the elderly is not only affected by physical conditions, social relations and other factors, but is also used as a measure of other aspects of happiness. This study examined the relationship between happiness and social relationships, contextual characteristics, and the medical outcomes of the elderly in China.Methods: Using multistage sampling method, a cross-sectional survey was conducted in Heilongjiang Province, China. 1003 elderly people participated in this study. We used the Life Satisfaction Scale, social isolation scale and EQ-5D to measure the happiness, social participation and health status of the elderly. In this study, structural equation modeling and descriptive analysis were used for analysis.Results: The main factors for happiness in the elderly were social relationships (γ = 0.507, P<0.001), contextual characteristics (γ= 0.256, P<0.001), and medical outcomes (γ= 0.232, P=0.015). Among these, the most important factor in the dimension of social relationships was social isolation (γ = -0.757 P<0.001), the most important factor in the dimension of contextual characteristics was monthly income (γ = 0.955 P<0.001), and the most important factor in the dimension of medical outcomes was physical health (γ = 0.600 P<0.001). There were also some relationships among three other dimensions.Conclusions：For the elderly, we must pay attention to social relations and reduce the sense of social isolation. At the same time, we should provide more medical resources for the elderly and maintain their health.
Detection of a novel gene mutation, ERBB2 exon 20 insertion, in bronchial adenoma using next-generation sequencing and a review of the literature
Authors: Wu Qian , Li Lin , Zheng Ke , Tang Yuan , Jiang Lili 
Published: June 2020

Abstract
Objectives: Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor and is a subtype of bronchial adenoma (BA). Although recent studies have suggested that BA is a neoplastic disease, the complete histogenesis of BA is not fully understood and molecular data are limited. Methods: We examined the clinicopathological features of four patients with BA and performed immunohistochemical analysis and next-generation sequencing to characterize the molecular features of BA. A review of the previous literature was also undertaken to comprehensively conclude the molecular characteristics of this disease. Results: From previous studies and the present study, 99 BA /CMPT cases have been reported to date, with most of the patients from East Asia (77/99, 77.8%). The median age was 64 years old and the ages ranged from 19 to 84 years. The proportion of males and females was close, being approximately 1:1.3. From the computed tomography images, the BA /CMPT tumor usually presented as a peripheral solid mass, part-solid nodules, or ground-glass opaque with an irregular border and occasional central cavities. ERBB2, EGFR, BRAF, and AKT1 mutations were found on the computed tomography images of the BAs. To the best of our knowledge, this is the first study to report about ERBB2 exon 20 insertion in BA. Conclusion: BA /CMPT is a rare pulmonary disease that mainly affects elderly Asian patients. Many abnormal molecular changes were found, which confirmed the neoplastic nature of BA /CMPT. However, it also added to the debate regarding the biological behavior of BA /CMPT.
1 Selenium Supply Alters Subcellular Distribution and Chemical Forms of Cadmium and Expression of Transporter Genes Involved in Cadmium Uptake and Translocation in Winter Wheat (Triticum Aestivum)
Authors: Zhu Jiaojiao , Zhao Peng , Nie Zhaojun , Shi Huazhong , Li Chang , Wang Yi , Qin Shiyu , Qin Xiaoming , Liu Hongen 
Published: June 2020

Abstract
Background

Cadmium (Cd) accumulation in crops will affect the yield and quality of crops, and also harm human health. The application of selenium (Se) can reduce the absorption and transport of Cd in winter wheat.
Results

The result showed that increasing Se supply significantly decreased Cd concentration and accumulation in shoots and roots of winter wheat, and the root to shoot translocation of Cd. The Se supply increased the root length, surface area and root volume, but decreased the root average diameter. Increasing Se supply significantly decreased Cd concentration in cell wall, soluble fraction and cell organelle in roots and shoots. An increase of Se supply inhibited Cd distribution in the organelle of shoot and root, but enhanced Cd distribution in the soluble fraction of shoot and the cell wall of root. The Se supply also decreased the proportion of active Cd (ethanol-extractable (FE) Cd and deionized water-extractable (FW) Cd) in roots. In addition, the expression of TaNramp5-a, TaNramp5-b, TaHMA3-a, TaHMA3-b and TaHMA2 were significantly increased with the increase of Cd concentration in roots, and the expression of TaNramp5-a, TaNramp5-b and TaHMA2 in roots were down-regulated by increasing Se supply, regardless of Se supply or Cd stress, respectively. The expression of TaHMA3-b in root was significantly down-regulated by Se10 treatment at both Cd5 and Cd25 but up-regulated by Se5 treatment at Cd25. The expression of TaNramp5-a, TaNramp5-b, TaHMA3-a, TaHMA3-b and TaHMA2 in shoot were down-regulated by increasing Se supply at Cd5, and Se5 treatment up-regulated the expression of those genes in shoot at Cd25.
Conclusions

The results confirm that Se application limit Cd accumulation in wheat via regulating subcellular distribution and the chemical forms of Cd in tissues of winter wheat, as well as the expression of TaNramp5-a, TaNramp5-b and TaHMA2 in root.
The Binding Behaviors between Cyclopentanocucurbit[6]uril and Three Amino Acids in the Solid and the Solution Phases
Authors: Cheng Si Yuan , Zhao Wei Wei , Yang Xi Nan , Wei Lian Tong , Tao Zhu , Ma Peihua 
Published: June 2020

Abstract
Binding behaviors between CyP 6 Q[6] and three have been investigated by means of X-ray crystallography, 1 H NMR spectroscopy,amino acids and isothermal titration calorimetry (ITC). The results showed that CyP 6 Q[6] forms a 1:2 inclusion complex with glycine, but 1:1 complexes with both leucine and lysine. Whereas the carboxyl group of glycine can enter the interior of the cavity of CyP6Q[6], only the alkyl chains of leucine and lysine can enter this cavity. Interestingly, leucine can adopt two different self-assembly modes upon its interaction with cucurbituril, depending on the external conditions, whereas glycine and lysine do not exhibit such behavior.
Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome before and after long-term continuous positive airway pressure treatment
Authors: Kotsiou Ourania S , Siachpazidou Dimitra I. , Pastaka Chaido , Gogou Eudoxia , Kechagia Maria , Varsamas Charalampos , Hatzoglou Chrissi , Gourgoulianis Konstantinos I. 
Published: June 2020

Abstract
Background: Hypoxia induces the production of adipocyte-derived mediators such as IL-6 in obstructive sleep apnea syndrome (OSAS). Low serum 25-hydroxyvitamin D (25(OH)D) levels have been linked to OSAS susceptibility. No data exist to assess whether there has been a correlation between vitamin D and IL-6 serum levels. The effect of CPAP therapy on IL-6 or 25(OH)D levels has yet to be investigated sufficiently in OSAS. We aimed at determining the serum levels of 25(OH)D and IL-6 in OSAS patients compared to non-apneic controls, investigating a possible correlation between 25(OH)D and IL-6 levels and evaluating the changes in IL-6 and 25(OH)D concentrations after twelve months of CPAP therapy in OSAS patients.Methods: 15 OSAS patients diagnosed by polysomnography and 15 non-apneic controls were included in the study. Serum IL-6 and 25(OH)D levels were measured before and after twelve-month CPAP therapy in the whole population and OSAS group, respectively.Results: IL-6 levels were significantly elevated in the OSAS group than the controls. IL-6 levels were positively correlated with OSAS severity, nocturnal hypoxemia, and body mass index (BMI). No difference was detected in 25(OH)D serum levels between groups. We found no correlation between IL-6 and 25(OH)D serum levels in two groups. No effect on IL-6 or 25(OH)D levels was detect after one year of effective CPAP therapy in OSAS patients.Conclusions: IL-6 levels were correlated with OSAS severity, hypoxemia, and BMI. No correlation between 25(OH)D and IL-6 levels and no effect of long-term CPAP on biomarkers were found in OSAS patients.
LINC00899 Promotes Osteogenic Differentiation and Alleviates Osteoporosis via Targeting miR-374a to Regulate RUNX2
Authors: Gao Xiaoya , Xue Yun , Yang Kechun 
Published: June 2020

Abstract
Objective: This study aims to illustrate the underlying molecular mechanisms of long noncoding RNAs (LncRNAs) LINC00899 in osteoporosis.Methods: Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) used to examine the levels of LINC00899, miR-374a and RUNX2 in clinical tissues or human bone mesenchymal stem cells (hBMSCs). The interaction between miR-374a and LINC00899 or RUNX2 was predicted by starBase and verified by luciferase reporter assay and RNA binding protein immunoprecipitation (RIP) assay. Results: The expression of LINC00899 was lowly expressed in osteoporotic patients’ bone tissues and knockdown of LINC00899 decreased the expression of osteogenesis-related genes. Moreover, LINC00899 was confirmed to inhibit miR-374a expression by direct interaction. the expression levels of LINC00899 were gradually increased, but miR-374a expression was decreased with the prolongation of osteogenic induction. Finally, we demonstrated that RUNX2 was a target of miR-374a, and the silencing of miR-374a partially abolished the inhibitory effect of LINC00899 knockdown on the expression of RUNX2, OPN and OCN.Conclusions: We demonstrated that LINC00899 facilitated osteogenic differentiation of hBMSCs and prevent osteoporosis by sponging miR-374a and enhancing RUNX2 expression, which might provide a useful therapeutic strategy for osteoporosis patients.
Incidence and clinical profiles of COVID-19 in patients with gynecological surgery: A single center descriptive study from Spain.
Authors: Oliver Reyes , Lopez-Gonzalez Gregorio , Galindo Alberto , Alvarez-Conejo Carmen , Aragon-Sanchez Sofia , Sanz-Ferrandez Maria Consuelo , Tejerizo-Garcia Alvaro 
Published: June 2020

Abstract
Background: The inflammatory reaction after a surgical intervention could exacerbate the course of the COVID-19. We aim to determine the rate of COVID-19 and its complications among gynecological surgeries in the context of different measures taken during the pandemic period in our department. Methods: A retrospective longitudinal observational study was conducted. Clinical records of patients who underwent gynecological surgery from March 1 st to April 10 th , 2020 were reviewed. During this period, three different approachs were made: first phase, without any screening or surgical restrictions; second phase, with presurgical epidemiological screening using a specific questionnaire; and third phase, also with presurgical SARS-COV-19 RT-PCR. During the second and third phases the surgical activity and complexity were restricted, and different workflows were established for patient with suspected/confirmed infection. After hospital discharge, telephone follow-up was performed and screening for COVID-19 was carried out. Complications from the disease were analyzed. Results : Of the 118 patients that underwent gynecological surgeries, 10 (8.5%) were perioperatively diagnosed with COVID-19. Of these patients, 8 (80%) were not pre-surgical screened for SARS-CoV-2 infection, neither clinical nor with RT-PCR. The other 2 (20%) were preoperative screened with RT-PCR, one of them with a positive test result. Screening false negative rate was 0.8%. No postoperative complications derived from COVID-19 were observed. Conclusions: The establishment of different surgical workflows, the reduction of surgical complexity, and the use of a pre-surgical screening to detect patient at SARS-CoV-2 infection risk, could reduce the postoperative complications derived from that infection and improve surgical outcomes.
A Baseline Survey on the Treatment Workflow and Pediatric IGRT Practice Among European Members of the Project-Based Consortium and the Pediatric Radiation Oncology Society (PROS).
Authors: Windmeijer Coen A.A. , Bel Arjan , Jong Rianne de , Balgobind Brian V. , Aznar Marianne C. , Beek Karen van , Beldjoudi Guillaume , Boterberg Tom , Cernea Dana M. , Daniels Laurien , Dieckmann Karin , Filippi Andrea R. , Haasbeek Cornelis J.A. , Hoeben Bianca , Janssens Geert O.R. , Josipovic Mirjana , Jürgens Hannes , Kouvelis Adam , Lassen Yasmin , Loginova Anna , Maduro John H. , Ondrová Barbora , Rombi Barbara , Steinmann Diana , Stokkevag Camilla , Theodorou Marilena , Timmermann Beate , Vasileva-Kodeyh Vaska , Zaletel Lorna Zadravec , Dijk Irma W.E.M. van 
Published: June 2020

Abstract
Background Image-guided radiotherapy (IGRT) enables high precision tumor treatment with potential for sparing healthy tissues. The value of pediatric IGRT is widely acknowledged, but there is no consensus on ‘best practice’. We aimed to assess clinical pediatric IGRT practice among European members of the Pediatric Radiation Oncology Society (PROS) and members of our project-based consortium.Methods A survey addressing radiotherapy preparation, planning and delivery in seven treatment sites was sent to European PROS members and/or our IGRT project-based consortium (70 institutes). Responses were collected from June-September 2018.Results Of the 42 responding institutes (response rate 60%), 33 indicated to treat children. 28/33 are photon-only institutes, 3/33 are dedicated proton (‘proton-only’) institutes and 2/33 use both. Immobilization includes facial masks (in 100% of brain, craniospinal axis (CSA) and head-and-neck (H&N) treatments), and vacuum cushions (all sites, except brain and H&N). Intensity-modulated radiotherapy and volumetric-modulated arc therapy are most frequently applied ranging from 71%-81% in respectively CSA (20/28), and extremities (21/26), followed by 3D conformal radiotherapy ranging from 36%-69% in respectively H&N (10/28), and extremities (18/26). Isotropic planning target volume (PTV) margins varied widely in brain and abdomen (range, 1-10mm). The use of in-room kilovolt cone-beam computed tomography ranges from 57%-86% in respectively CSA (16/28), and thorax (24/28). Daily online imaging is used by the majority of institutes, ranging from 85%-90% in respectively extremities (22/26) and pelvis (27/30). Offline imaging protocols are used by 14%-21% in respectively H&N (4/28) and thorax (6/28).Conclusions Our survey shows comparable practice in pre-treatment imaging, planning and treatment techniques, and IGRT application among the participating European institutes. However, wide ranges in PTV margin sizes exist, supporting the need to define international ‘best practice’ guidelines for pediatric IGRT, and to aim for consensus on optimal margin definitions in view of available IGRT facilities and workflows among institutes.
Myofascial trigger-point compression therapy as an adjunct to exercise program is superior in alleviating chronic low back pain compared to exercise program alone
Authors: Masarwa Rawan , Uri Ofir , Peled Givon , Laufer Gil , Gutman Gabriel , Behrbalk Eyal 
Published: June 2020

Abstract
Background

Current guidelines for the treatment of low back pain (LBP) endorse physical exercise programs and a range of non-pharmacological complementary therapies. Myofascial trigger points (MTrPs) compression therapy is a well-established form of manual therapy, which aims to induce temporary ischemia and over-stimulation of mechanoreceptors over a desired area in order to restore tissue normal functional conditions required for healing response. The purpose of the current study was to evaluate the effect of MTrPs compression therapy as an adjunct to active exercise program in alleviating chronic non-specific low back pain.
Methods

One-hundred and three patients with chronic non-specific LBP were retrospectively reviewed, 45 of them were treated with MTrPs compression therapy as an adjunct to physical exercise program (MTrPs group) and 58 were treated with exercise program alone (control group). Pain and functional scores were compared before initiating treatment and at 3-month follow-up.
Results

Pain reduction at 3-month follow-up was 5.6 points (0–10 numerical scale) in the MTrPs group compared to 3.6 points in the control group (p < 0.001). Oswestry Disability Index and SF-12 life quality scores also improved significantly more in the MTrPs group compared to the control group at 3-month follow-up (p < 0.001).
Conclusions

Myofascial trigger points compression therapy as an adjunct to active exercise program provides superior pain and disability relief to patients with chronic LBP compared to active exercise program alone.
Evaluation of skin-surface interleukin 1 alpha, interleukin-1 Receptor Antagonist, CXCL-1/2 and beta-defensin-1 as non-invasive biomarkers for monitoring psoriasis vulgaris
Authors: Orro Kadri , Salk Kristiina , Abram Kristi , Arshavskaja Jelena , Meikas Anne , Karelson Maire , Neuman Toomas , Kingo Külli , Spee Pieter 
Published: June 2020

Abstract
Background:

Psoriatic skin is typically evaluated through visual assessment of its clinical hallmarks: thickness, redness and scaling of skin lesions. Sonography is used to physically monitor disease severity through physical assessment of the skin outer layers. Both methods assess consequences of inflammation rather than the molecular basis of disease. The aim of the current study was to assess 1) whether expression patterns of IL-1α, IL-1RA, CXCL-1, CXCL-2, and hBD-1, examples of proteins known to drive psoriasis pathology, can be measured non-invasively from the skin surface, 2) whether expression patterns of these proteins correlate with disease severity, and 3) whether skin surface expression of these proteins can be used to measure pharmacodynamic effects of psoriasis treatment.
Results:

Using non-invasive FibroTx TAP technology for sampling and measurements of proteins from the skin of psoriasis patients revealed clear differences of IL-1α, IL-1RA, CXCL-1/2 on lesional skin when compared to non-lesional skin or skin from healthy volunteers. Comparing these expression patterns with visual assessment of thickness, redness and scaling of skin lesions revealed no significant quantitative correlations, with the exception of a weak correlation between CXCL-1/2 and thickness of lesions. Similarly, there were no significant correlations between FibroTx TAP measurements and ultrasound measurements, with the exception of a weak correlation between CXCL-1/2 and SLEB thickness. The potential of these skin-surface biomarkers were studied by monitoring skin lesions of psoriasis patients undergoing narrow-band UVB (311 nm) phototherapy. During the course of UVB treatment, clear patterns towards normalisation of IL-1RA and CXCL-1/2 were observed on lesions measured.
Conclusions:

Skin surface measurements of proteins involved in psoriasis skin pathology, in this study exemplified by IL-1α, IL-1RA, CXCL-1/2 and hBD-1, have potential as biomarkers for monitoring severity of disease, as well as for monitoring pharmacodynamic changes. Skin surface measurements of IL-1RA and CXCL-1/2 displayed a different profile than achieved by visual scoring of local inflammation or sonography, thus confirming that measuring the ‘molecular root’ of inflammation appears to have value as an objective, non-invasive biomarker measurement for scoring disease severity in its own right.
Results of postoperative anti-rotation on the intracapsular femoral neck fracture fixed with cannulated screws
Authors: ren bu-fang , ma quan-ping , lv xin , yin yunsheng , gao yaozhu 
Published: June 2020

Abstract
Background: To investigate effect of postoperative anti-rotation on the union of intracapsular displaced femoral neck fracture treated with three cannulated screws. Methods: A retrospective analysis was performed on all the intracapsular femoral neck fractures treated in the department of orthopedics of the second Hospital of Shanxi Medical University from July 2015 to December 2018. Fractures of femoral neck were reduced and fixed with three cannulated screws. The patients who wore anti-rotation shoes in the affected side were kept at bed rest for 10-12 weeks after surgery. The results were analyzed.Results: A total of 135 patients were included in the analysis. Six patients (4.4%) were not united. There were 12 cases of avascular necrosis (9.3%). No wound infections, screw breakages was found.Conclusion: Anti-rotation after surgery can significantly reduce the rate of femoral neck fracture nonunion, but not significantly improve the femoral head necrosis