bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photonic-Plasmonic Mode Coupling in Nanopillar Ge-On-Si Pin Photodiodes
Authors: Augel Lion , Schlipf Jon , Bullert Sergej , Bürzele Sebastian , Schulze Jörg , Fischer Inga 
Published: November 2020

Abstract
Incorporating group IV photonic nanostructures within active top-illuminated photonic devices often requires light-transmissive contact schemes. In this context, plasmonic nanoapertures in metallic films can not only be realized using CMOS compatible metals and processes, they can also serve to influence the wavelength-dependent device responsivities. Here, we investigate crescent-shaped nanoapertures in close proximity to Ge-on-Si PIN nanopillar photodetectors both in simulation and experiment. In our geometries, the absorption within the devices is mainly shaped by the absorption characteristics of the vertical semiconductor nanopillar structures (leaky waveguide modes). The plasmonic resonances can be used to influence how incident light couples into the leaky modes within the nanopillars. Our results can serve as a starting point to selectively tune our device geometries for applications in spectroscopy or refractive index sensing.
Quantitative Determination of Spin-Orbit-Induced Magnetic Field in GaMnAs by Field-Scan Planar Hall Measurements
Authors: Park Seongjoon , Lee Shinwoo , Lee Kyung Jae , park SeongJin , Chongthanaphisut Phunvira , Jang Jiyeong , Liu Xinyu , Dobrowolska M. , Furdyna Jacek , Lee Sanghoon 
Published: November 2020

Abstract
Spin-orbit-induced (SOI) effective magnetic field in GaMnAs film with in-plane magnetic anisotropy has been investigated by planar Hall effect measurements. The presence of SOI field was identified by a shift between planar Hall resistance (PHR) hystereses observed with positive and negative currents. The difference of switching fields occurring between the two current polarities, which is determined by the strength of the SOI field, is shown to depend on the external field direction. In this paper we have developed a method for obtaining the magnitude of the SOI fields based on magnetic free energy that includes the effects of magnetic anisotropy and the SOI field. Using this approach, the SOI field for a given current density was accurately obtained by fitting to the observed dependence of the switching fields on the applied field directions. Values of the SOI field obtained with field scan PHR measurements give results that are consistent with those obtained by analyzing the angular dependence of PHR, indicating the reliability of the field scan PHR method for quantifying the SOI-field in GaMnAs films. The magnitude of the SOI field systematically increases with increasing current density, demonstrating the usefulness of SOI fields for manipulation of magnetization by current in GaMnAs films.
Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial
Authors: Niaee Morteza Shakhsi , Gheibi Nematollah , Namdar Peyman , Allami Abbas , Zolghadr Leila , Javadi Amir , Karampour Amin , Varnaseri Mehran , Bizhani Behzad , Cheraghi Fatemeh , Naderi Yazdan , Amini Fatemeh , Karamyan Masoumeh , Yadyad Mohammad Jafar , Jamshidian Ramin 
Published: November 2020

Abstract

Background: It appears that ivermectin can potentially act against COVID-19 infection. Today, it is an urgent need to evaluate the efficacy and safety of ivermectin. The effect of ivermectin therapy on mild to severe COVID-19 patients was investigated.Methods: A 45-days randomized, double-blind, placebo-controlled, multicenter, phase 2 clinical trial was designed at five hospitals. A total number of 180 mild to severe hospitalized patients with confirmed PCR and chest image tests were enrolled. The radiographic findings, hospitalization and low O2 saturation duration, and clinical outcomes such as mortality and variables of blood samples were analyzed using standard statistical analyses in SPSS (V20).Results: Average age of the participants was 56 years (45-67) and 50% were women. The primary and secondary results showed significant changes between day zero and day five of admission (∆ 0/5) in terms of ΔALC5/0, ΔPLT5/0, ΔESR5/0, ΔCRP5/0, duration of low O2 saturation, and duration of hospitalization (CI = 95% ). Risk of mortality was also decreased significantly in the study groups.Conclusion: Ivermectin as an adjunct reduced the rate of mortality, low O2 duration, and duration of hospitalization in adult COVID 19 patients. The improvement of other clinical parameters showed that the ivermectin, with a wide margin of safety, had a high therapeutic effect on COVID-19.Trial Registration: This trial was registered with the Iranian Registry of Clinical Trials website (registration ID IRCT20200408046987N1).
Coal and Gas Outbursts Prediction Based on DWT+FICA-LDA Feature Extraction and QPSO-DELM Classifier
Authors: Liu Xuning , Li Zhixiang , Zhang Zixian , Zhang Guoying 
Published: November 2020

Abstract
Due to the severity and great harm of coal and gas outbursts accidents, outbursts prediction becomes very necessary, the paper presents a hybrid prediction model of feature extraction and pattern classification for coal and gas outbursts. First, Discrete wavelet transform (DWT) is utilized as a processing technique to decompose subseries and extract the features with different frequency, and the optimal feature components are retained; Second, in order to eliminate the redundancy between the features and uncorrelation between feature and outbursts, we use the fast independent component analysis(FICA) feature extraction method based on high-order statistics to obtain each independent feature, obtaining the global information in the feature; then the obtained features are input into linear discriminant analysis(LDA) , under the guidance of class label, then the local information in features are obtained; Finally, the projected features are input into the deep extreme learning machine(DELM) classifier based on the optimal parameters by quantum particle swarm optimization(QPSO) for training and classification. The experimental results on the data set of coal and gas outbursts show that compared with other models in the current prediction of coal and gas outbursts, this method has significant effect on various indicators such as speed and recognition effect.
RNF216 Promotes Occurrence and Progression of Cholangiocarcinoma via Regulation of the DIAPH3 Ubiquitination
Authors: Tu Jianfei , Chen Weiqian , Meng Miaomiao , Zhao Siyu , Wu Fazong , Fang Shiji , Shen Lin , Kong Chunli , Ying Xihui , Chen Li , Liu Lu , Hu Xianghua , Zhao Zhongwei , Fan Xiaoxi , Ji Jiansong 
Published: November 2020

Abstract
BackgroundCholangiocarcinoma is a relatively uncommon malignant tumor with high mortality. However, the molecular underpinnings behind malignant progression of cholangiocarcinoma are incompletely understood. Here we demonstrate that RNF216 plays a suppressive role in cholangiocarcinoma occurrence and metastasis.MethodsIHC and Western blot analysis were performed to examine the expression pattern of RNF216 and DIAPH3 in the clinical CRC cholangiocarcinoma. The relationship between RNF216 and DIAPH3 was then validated using in western blot analysis. The mechanism of RNF216-mediated ubiquitination modification of DIAPH3 was analyzed via Co-IP analysis. Gain- or loss-of-function approaches were manipulated to evaluate the modulatory effects of RNF216 and DIAPH3 on cell growth and metastasis. The mediatory effects of RNF216 and DIAPH3 on cancerogenesis were validated in vivo.ResultsClinical data indicated that expression levels of RNF216 were associated with favorable clinical outcomes. RNF216 was downregulated in cholangiocarcinoma and inhibited cell proliferation and colony formation in vitro and xenograft tumorigenicity in vivo. Moreover, RNF216 suppressed Invasion and migration of cholangiocarcinoma. Mechanistic investigations further showed that RNF216 was involved in the ubiquitination of DIAPH3, a member of formin family related to assembly of actin cytoskeleton. RNF216 elicits tumor suppressor role by promoting degradation of DIAPH3. Importantly, expression of DIAPH3 rescued RNF216-mediated suppression of proliferation, cell migration, and invasion. Conclusion﻿Our findings uncover a suppressive role for RNF216 in cholangiocarcinoma proliferation and metastatic progression and provide novel insight into that RNF216 is a potential biomarker or serves as a therapeutic target for cholangiocarcinoma.
Sarcopenia and Coronary Heart Disease Synergistically Increase the Risk of New Onset Depressive Symptoms in Older Adults
Authors: Chen Xiaoyu , Han Peipei , Yu Xing , Zhang Yuanyuan , Song Peiyu , Liu Yuewen , Liu Jinghuan , Tang Jiawei , Zhang Yisong , Zhao Yong , Zheng Jiejiao , Chu Lixi , Guo Qi 
Published: November 2020

Abstract
Background: It is well known that psychological and physical are very common among the elderly. This study aimed to investigate the additive effects of coronary heart disease (CHD) and sarcopenia on the risk of new onset depressive symptoms in older adults. Methods: The prospective cohort study comprised 897 Chinese community-dwelling participants who were aged 60 years and older (386 men; mean age 66.9±5.9 years) without depressive symptoms at baseline, recruited from Chadian of Tianjin, China. Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) criteria. CHD was identified via medical records or new diagnosed by at least two physicians. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) ≥11. Longitudinal data on new onset depressive symptoms were collected up to 12 months after baseline.Results: We found that 103 (11.5%) of the 897 participants without depressive symptoms at baseline had developed depressive symptoms. Participants were classified into mutually exclusive groups based on sarcopenia status and CHD: normal, CHD alone, sarcopenia alone, and co-occurring groups. A logistic regression showed that the CHD alone [odd ratios (OR) = 1.81, 95% confidence interval (CI) = 1.07-3.07]], sarcopenia alone (OR = 2.77, 95% CI = 1.24-6.16), and co-occurring (OR = 7.12, 95% CI = 2.73-18.61) had higher risk of depressive symptoms than the normal group after adjusting for the covariates.Conclusions: CHD and sarcopenia synergistically increase the risk of new onset depressive symptoms in older adults. Thus, older adults may require early detection, and appropriate interventions should be implemented.
Clinical impact and imaging results after a modified procedure of ACDF: a prospective case-controlled study based on ninety cases with two-year follow-up
Authors: Wang Shunmin , Zhu Jian , Sun Kaiqiang , Chen Rongzi , Cao Jie , Guo Yongfei , Liu Aigang , Zhao Feng , Shi Jiangang 
Published: November 2020

Abstract
Study design This is a prospective case-controlled studyPurpose: To analyze the postoperative axial pain and cage subsidence of patients presenting with cervical spondylotic myelopathy (CSM) after a modified procedure of ACDF (mACDF). Methods: 90 patients with CSM were prospectively collected from 2014 to 2018. The patients were divided into spread group and non-spread group (48:42 ratio) according to the cage placement with or without releasing the Caspar cervical retractor after decompression. Spread group received conventional ACDF and non-spread group received mACDF. Patients were followed-up for at least 24 months after surgery. Radiologic data, including height of intervertebral space and Cobb Angle, were collected. Nervous system function was obtained using JOA scores, and level of pain was assessed using VAS scores.Results: A total of 90 patients were enrolled and the patients were divided into spread group (n=48) and none-spread group(n=42). Cage subsidence of (spread group vs none-spread group) was (0.82±0.68 vs 0.58±0.81) mm, (0.64±0.77 vs 0.34±0.46) mm, (0.48±0.43 vs 0.25±0.28) mm, and (0.45±0.47 vs 0.17±0.32) mm at 3months, 6months, 12months and 24 months, respectively. The period exhibiting the most decrease of the height of intervertebral space was 3 months postoperatively. However, there was no statistical difference in the height of intervertebral space, JOA or VAS scores at the final follow-up between the two groups. Conclusion: The mACDF can avoid excessive distraction by releasing the Caspar Cervical retractor, restore the "natural height" of cervical vertebra, reduce the occurrence of axial pain in patients with CSM involving single-level, and prevent rapid Cage subsidence and the loss of cervical curvatur
A matrix for the evaluation of COVID-19 contact risk in healthcare workers: Technical note
Authors: Durmaz Seyfi , Durusoy Raika 
Published: November 2020

Abstract
Detecting risky contacts and early isolation of healthcare workers who have been in contact with COVID-19 cases will increase the likelihood of limiting the spread of the infection. The aim of this technical note is to propose a reliable, fast-adaptable and easy-to-use matrix that accurately classifies risk for contact tracing of healthcare workers with COVID-19 patients. The researchers have created a matrix with the support of the literature and their experience within the university hospital surveillance team. This matrix enables a detailed High / Medium / Low Risk classification of contacts of healthcare workers with COVID-19 cases, covering many different contact situations encountered in a university hospital. The distinction between different contact risk categories implies different preventive measures: High-risk contacts are isolated at home for 7 days and return to work if they test PCR-negative on day 7; while medium and low risk contacts continue to work using masks, with medium-risk contacts tested on day 7, so it is important to standardize the classification among different interviewers. Three main headings have come to the fore in health worker contact risk classification: 1. Differences caused by the ventilation of the environment: Indoors, well ventilated indoors, outdoors. 2. Direct contact or material sharing. 3. Aerosol generating procedure (AGP). The matrix has been used effectively in 1169 risky contact interviews over a two-month period (24 August - 23 October 2020). It has been evaluated by two groups: the surveillance team using it routinely for contact tracing and by experts. The matrix is quickly adapted by new surveillance team members and is easy to use.
Focal Segmental Glomerulosclerosis with a Mutation in the Mitochondrially Encoded NADH Dehydrogenase 5 Gene: A Case Report
Authors: Naganuma Tsukasa , Imasawa Toshiyuki , Nukui Ikuo , Wakasugi Masakiyo , Kitamura Hiroshi , Yatsuka Yukiko , Kishita Yoshihito , Okazaki Yasushi , Murayama Kei , Jinguji Yoshimi 
Published: November 2020

Abstract

Background: NADH dehydrogenase 5 (ND5) is one of 44 subunits forming Complex I in the mitochondrial respiratory chain. Therefore, a mitochondrially encoded ND5 (MT-ND5) gene mutation causes mitochondrial oxidative phosphorylation (OXPHOS) disorder, resulting in the development of mitochondrial diseases, such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. Although focal segmental glomerulosclerosis (FSGS) is induced by several mitochondrial diseases, no reports have yet confirmed that an MT-ND5 mutation causes FSGS. Case presentation: A Japanese woman at 29 years old was found to have proteinuria and renal dysfunction in an annual health check-up for the first time. Because her proteinuria and renal dysfunction were persistent, she was admitted for a kidney biopsy to investigate the reason at 33 years of age. Although there were no abnormal neurological findings, she was diagnosed with sensorineural hearing loss by an otolaryngologist. Renal histology showed perihilar variant-type FSGS with podocytes filled with abnormal mitochondria. In addition, the renal pathological findings showed granular swollen epithelial cells (GSECs) in tubular cells, age-inappropriately disarranged and irregularly sized vascular smooth muscle cells (AiDIVs), and red-colored podocytes (ReCPos) by acidic dye, which are assumed to be characteristic changes of mitochondrial nephropathy. Genetic analysis using peripheral mononuclear blood cells and urine sediment cells detected the m.13513 G>A variant, which has already been confirmed as a pathogenic variant of the MT-ND5 gene. The heteroplasmy rates of the blood cells and urine sediments were 10.3% and 62.2%, respectively. Therefore, this patient was diagnosed with FSGS due to an MT-ND5 mutation. Conclusion: This is the first case report to show that a gene mutation encoding subunits of Complex I causes FSGS with podocytes filled with abnormal mitochondria. The routine evaluation of GSECs, AiDIVs, and ReCPos is expected to be useful for detecting mitochondrial nephropathies, which could be latent in etiology-unknown FSGS or glomerulosclerosis cases.
Carcinosarcoma of the Gallbladder with Two Heterologous Components: A Case Report and Review of the Literature
Authors: TIABI EL MEHDI , MIRY ACHRAF , HALOUI ANASS , NAJIOUI YOUNESSE , BOUDOU MOHAMED , KARICH NASSIRA , BOUZIANE MOHAMMED , BENNANI AMAL 
Published: November 2020

Abstract
IntroductionGallbladder carcinosarcoma [CSGB] is a rare malignant tumor characterized by malignant epithelial and mesenchymal components. Its pathogenesis is unknown and most CSGBs are associated with poor survival because the disease normally presents at an advanced stage and, therefore, curative resection is rare. Case report This report describes the case of a 66-year-old man with pain in the upper right quadrant. The preoperative diagnosis was cancer of the gallbladder [GB], and therefore, a curative radical cholecystectomy was performed. However, pathological examination of the surgical sample revealed that the tumor was made up of two histological components. The first one is the carcinomatous component and the second one corresponds to the sarcomatous component, which was compatible with a diagnosis of carcinosarcoma. ConclusionThe prognosis for CSGB remains poor despite curative resection, and therefore, the authors recommend that efforts be made to improve surgical outcomes.
Optical trapping by petal-like circular Airy beam
Authors: Shahabadi Vahid , Abdollahpour Daryoush 
Published: November 2020

Abstract
Superposition of two circular Airy vortex beams (CAVB), with opposite sign topological charges (l), produces a new type of petal beams called petal-like circular Airy beam (PCAB) with a transverse field distribution in the form of azimuthally modulated concentric rings that follow Airy function over the radial distance on a transverse plane. In this paper, tight focusing of truncated PCAB and its application in optical trapping is numerically investigated. It is shown that by adjusting the beam parameters four different trapping configurations can be achieved: a single transverse trap at a single axial position, a multi-trap geometry at a single axial position, two single transverse traps at two positions along the axial direction, and two multi-trap geometries at two different axial positions. It is also shown that the number of trapped particles in the multi-trap configurations is 2l per focal plane, while the number of axial trap positions is determined by the truncation aperture size. Finally, trap stiffnesses and corresponding potential energies for the trapping configurations are presented and discussed.
Prevalence of Malnutrition Inflammation Complex Syndrome among Patients on Maintenance Haemodialysis at Muhimbili National Hospital in Tanzania: A Cross-Sectional Study
Authors: Bramania Puneet Kishore , Ruggajo Paschal , Bramania Rimal , Mahmoud Muhiddin , Furia Francis Fredrick 
Published: November 2020

Abstract
Background: Malnutrition, inflammation, and the combination thereof are predictors of poor outcomes in haemodialysis patients. Malnutrition Inflammation Complex Syndrome (MICS) is an accelerator of atherosclerosis and portends high mortality. Early recognition and treatment of MICS may help to improve the clinical outlook of such patients. This study investigated the prevalence of MICS and its associated factors among patients on maintenance haemodialysis at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.
Methods: This was a prospective cross-sectional observational study done among 160 adult patients on maintenance haemodialysis at MNH in 2019. All participants provided written informed consent. Questionnaires were used to collect data and patients’ blood was tested for complete blood count (CBC), C-reactive protein (CRP), ferritin, transferrin, creatinine, urea, total cholesterol, and albumin. The Malnutrition Inflammation Score was used to assess MICS and its severity. Data analysis was done using the SPSS 20 software.
Results: Of the 160 patients included in the study, 111 (69.4%) were male. The mean age (±SD) of patients and mean duration (±SD) on haemodialysis were 52.2(13.3) years and 22(18) months respectively. MICS was prevalent in 46.3% (mild in 24.4% and moderate to severe in 21.9%).
Long-term haemodialysis (>4years) was an independent predictor of MICS [Adjusted Odds Ratio, AOR 5.04 (95% CI: 1.33–19.2), p<0.05]. Hypercholesterolaemia was a negative predictor of MICS [AOR 0.11 (95% CI: 0.01-0.97), p<0.05]. Patients with MICS had significantly lower mean body mass index, serum albumin, total cholesterol, transferrin, haemoglobin, and creatinine levels. The presence of MICS was higher in underweight patients and those who had inflammation. Haemodialysis adequacy did not correlate with MICS.
Conclusion: Malnutrition Inflammation Complex Syndrome is relatively common among patients on haemodialysis in Dar es Salaam, Tanzania. Our study has shown a longer duration on haemodialysis to be associated with the occurrence of MICS; on the contrary, having hypercholesterolaemia seems to be protective against MICS consistent with the concept of reverse epidemiology. Patients on haemodialysis should be assessed regularly for malnutrition and inflammation and should receive appropriate and timely treatment to reduce the burden of associated morbidity, and mortality to these patients.