bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer’s disease mice
Authors: Jew Katrina , Herr Denise , Wong Candace , Kennell Andrea , Morris-Schaffer Keith , Oberdörster Günter , O’Banion M. Kerry , Cory-Slechta Deborah A. , Elder Alison 
Published: November 2019

Abstract
Background
A growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated Alzheimer’s disease (AD) risk and may exacerbate AD-related cognitive decline. Of concern is exposure to the ultrafine PM (UFP) fraction (≤100 nm), which deposits efficiently throughout the respiratory tract, has higher rates of translocation to secondary organs, like brain, and may induce inflammatory changes. We, therefore, hypothesize that exposure to UFPs will exacerbate cognitive deficits in a mouse model of AD. The present study assessed alterations in learning and memory behaviors in aged (12.5 months) male 3xTgAD and non-transgenic mice following a 2-week exposure (4-h/day, 4 days/week) to concentrated ambient UFPs using the Harvard ultrafine concentrated ambient particle system (HUCAPS) or filtered air. Beginning one month following exposure, locomotor activity, spatial learning and memory, short-term recognition memory, appetitive motivation, and olfactory discrimination were assessed.

Results
No effects on locomotor activity were found following HUCAPS exposure (number concentration, 1 × 104–4.7 × 105 particles/cm3; mass concentration, 29–132 μg/m3). HUCAPS-exposed mice, independent of AD background, showed a significantly decreased spatial learning, mediated through reference memory deficits, as well as short-term memory deficits in novel object recognition testing. AD mice displayed diminished spatial working memory, potentially a result of olfactory deficits, and short-term memory. AD background modulated HUCAPS-induced changes on appetitive motivation and olfactory discrimination, specifically enhancing olfactory discrimination in NTg mice. Modeling variation in appetitive motivation as a covariate in spatial learning and memory, however, did not support the conclusion that differences in motivation significantly underlie changes in spatial learning and memory.

Conclusions
A short-term inhalation exposure of aged mice to ambient UFPs at human-relevant concentrations resulted in protracted (testing spanning 1–6.5 months post-exposure) adverse effects on multiple memory domains (reference and short-term memory) independent of AD background. Impairments in learning and memory were present when accounting for potential covariates like motivational changes and locomotor activity. These results highlight the need for further research into the potential mechanisms underlying the cognitive effects of UFP exposure in adulthood.
Sweden’s engagement in global health: a historical review
Authors: Irwin Rachel 
Published: November 2019

Abstract
Background
Sweden is a long-standing and significant contributor to overseas development aid. This commitment to global health and development is part of Sverigebilden, or the view of Sweden in the world that is formally promoted by the Swedish government. Sweden is seen by many in the global health community as leader on human rights and health and has traditionally been one of the most engaged countries in multilateral affairs more broadly.

Results
This article places Sweden’s engagement in global health within the wider context of domestic changes, as well as transitions within the broader global health landscape in the post-World War Two (WWII)- era. In doing so, it reviews the globalization of health from a Swedish perspective. It also addresses broader questions about what it means for a country to be ‘active’ or ‘engaged’ in global health and responds to recent suggestions that Swedish influence in health has waned. The article finds that in Sweden there is wide political consensus that international development and global health engagement are important, and both are part of the maintenance of Sverigebilen. While there is a not one single Swedish approach to global health, there are norms and values that underpin global health engagement such as human rights, solidarity, equity and gender equality. A sustained focus on key issues, such as sexual and reproductive rights and health (SRHR), creates a tradition which feeds back into Sverigebilden.

Conclusions
The Swedish experience demonstrates the linkages between foreign and domestic policies with regard to international health and development, and to the globalization of public health practice and diplomacy. In global health Sverigebilden is tied to credibility. Sweden is able to exercise influence because of a successful welfare model and strong research traditions; conversely, long-standing and new threats to this credibility and to Sverigebilden pose challenges to Sweden’s future engagement in global health.
A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation
Authors: Khumalo Mandlenkosi Robert , Maddila Surya Narayana , Maddila Suresh , Jonnalagadda Sreekantha B. 
Published: November 2019

AbstractEleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup.
Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis
Authors: Grotto Denise , Camargo Isabella Ferreira , Kodaira Katia , Mazzei Lauren Giustti , Castro Juliana , Vieira Raquel Andrade Leite , Bergamaschi Cristiane de Cásia , Lopes Luciane Cruz 
Published: November 2019

Abstract
Background
Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body weight are uncertain. The aim of this systematic review is to determine the efficacy of mushrooms in weight loss in animal preclinical models.

Method
This is a systematic review of preclinical studies of animal models of obesity (any type of non-aquatic mammal), which were exposed to edible and medicinal mushrooms orally in comparison with the control. The following databases will be used: MEDLINE (PubMed), Web of Science, BIOSIS, SCOPUS, and gray literature. There will be no restriction of language, date, or publication status. The primary outcome will be body weight loss. And the secondary outcomes include the total amount of food consumed by the animals, analysis of metabolic parameters, inflammatory mediators, mortality for any causes, and any adverse effect reported. A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias risk (using SYstematic Review Centre for Laboratory animal Experimentation SYRCLE’s risk of bias tool and the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist). The standardized mean difference (SMD) will be calculated to measure treatment effect, with 95% confidence intervals (95% CI). The heterogeneity between-study will be calculated by I2 inconsistency values and Cochran’s Q statistical test, where I2 > 50% and/or p < 0.10 suggest high heterogeneity meta-analyses of random effects will be conducted as possible.

Discussion
Although many experimental studies about the effects of mushrooms on obesity have already been published, there is still no consensus in the literature. This study will provide evidences of preclinical research on mushrooms and their relation to body weight loss in animal models of obesity, being non-aquatic mammals. Also, this systematic review will show the limitations and strengths of the studies available in the literature, as well as it will to encourage the financing of new studies by public health managers and governmental entities.

Systematic review registration
PROSPERO (CRD42019125299).
Measuring informal STEM learning supports across contexts and time
Authors: Morris Bradley J. , Owens Whitney , Ellenbogen Kirsten , Erduran Sibel , Dunlosky John 
Published: November 2019

Abstract
Background
Informal science activities are critical for supporting long-term learning in STEM fields. However, little is known about the kinds of activities children and their families engage in outside of formal settings and how such activities foster long-term STEM engagement. One gap in the literature is the lack of data that document self-designated STEM activities and measure their impact on later engagement with learning opportunities that are distributed over time and contexts (i.e., the informal learning ecology). One reason for this gap is that there has been little measurement during the events, because using only a few measures (which can be completed briefly) may reduce psychometric validity. We developed an instrument, the STEMwhere app, to measure four informal science learning supports (interest, engagement, identity, and goal setting), across the informal learning ecology. For a period of 2 months, 26 children ages 7–14 used the app to check-in during STEM activities and answer eight questions about each activity.

Results
The results demonstrated that most STEM activities occurred in the home, often consisted of hands-on activities, suggesting that the family home provides more opportunity for engagement than other locations. Child interest and engagement ratings were high in all settings and activities suggesting that high situational interest was relatively common during these activities. Further, user ratings suggested relations between different learning supports. For example, increases in interest were related to increases in subsequent engagement and “fun” goals, while increases in engagement were related to increases in learning goals. By collecting participant-generated check-ins, we identified periods of increasing activity and their likely triggers, which is a novel measure we refer to as topical runs. We operationally defined a run as a pattern of check-ins that were unlikely to occur by chance and shared a topic or location.

Conclusions
Our results serve as both a proof-of-concept for a novel tool for measuring informal STEM activity in the wild that provides data consistent with existing measures and provide novel findings that contribute to our understanding of where and how informal science activity occurs.
Travel medicine, coca and cocaine: demystifying and rehabilitating Erythroxylum – a comprehensive review
Authors: Bauer Irmgard 
Published: November 2019

AbstractFew travel health measures are as controversial as the use of coca leaves at high altitude; yet, there appears widespread ignorance among health professionals and the general public about coca, its origins as well as its interesting and often flamboyant history. Equally, the cultural and traditional significance to Andean people is not recognised. The coca leaves contain many alkaloids, one of which, cocaine, has gained notoriety as a narcotic, leading to the mistaken idea that coca equals cocaine. This article contrasts coca with cocaine in an attempt to explain the differences but also the reasons for this widespread misconception. By its very nature, there may never be scientific ‘proof’ that coca leaves do or do not work for travellers at altitude, but at least a solid knowledge of coca, and how it differs from cocaine, provides a platform for informed opinions and appropriate critical views on the current confusing and contradictory legal situation.
Change of the upper airway after mandibular setback surgery in patients with mandibular prognathism and anterior open bite
Authors: Lee Kyungjin , Hwang Soon Jung 
Published: November 2019

Abstract
Purpose
It has been reported before that the amount of pharyngeal airway space (PAS) significantly decreases following mandibular setback (MS) surgery in patients with mandibular prognathism (MP). Further, MP patients with an anterior open-bite (AOB) presentation may show a larger decrease in PAS compared with those without AOB. However, studies on postoperative PAS changes in MP patients with AOB remain rare. This study sought to evaluate changes in PAS and hyoid bone positioning following MS surgery in MP patients with and without AOB.

Patients and methods
Twenty patients who underwent two jaw surgery involving MS movement were included. Patients were divided into a non-AOB group (n = 10; overbite > 2 mm) and an AOB group (n = 10; overbite < − 4 mm). Three-dimensional changes in PAS and hyoid bone positioning were compared and statistically evaluated pre- and postoperatively using computed tomography (CT).

Results
The mean magnitude of MS was 6.0 ± 2.8 mm and 5.6 ± 3.2 mm in the non-AOB group and AOB group, respectively. The oropharyngeal volume and upper hypopharyngeal volume were significantly reduced after surgery in both the groups (p = 0.006 and p = 0.003), while the retroglossal cross-sectional area was significantly reduced only in the AOB group (p = 0.028). Although the AOB group showed a larger decrease in PAS, the difference was not statistically significant between the groups. The position of the hyoid bone showed significant posterior and inferior displacement only in the AOB group, while the vertical displacement of the hyoid bone showed a statistically significant difference between the two groups.

Conclusion
PAS was significantly decreased after MS in both the groups, while only the AOB group presented a statistically significant reduction in the retroglossal cross-sectional area. Vertical displacement of the hyoid bone showed a statistically significant difference between the groups, while the PAS change was not. Surgeons should be aware of potential postoperative airway problems that may arise when performing MS surgeries.
Six-year epidemiological analysis of post traumatic endophthalmitis in a Brazilian hospital
Authors: Nakayama Luis Filipe , Bergamo Vinicius Campos , de Moraes Nilva Simeren Bueno 
Published: November 2019

Abstract
Background
To evaluate the epidemiology of endophthalmitis cases related to ocular trauma, including visual acuity during and 1 year after trauma, source of trauma and method of treatment.

Methods
A retrospective study analyzed the epidemiological data of patients with a clinical presentation of endophthalmitis after ocular penetrating trauma between January 2012 and January 2017 at Escola Paulista de Medicina/UNIFESP, a hospital in São Paulo, SP, Brazil.

Results
A total of 453 patients with antecedent open globe trauma were evaluated, among these, 30 patients with suspected endophthalmitis. All patients were male. The time interval between trauma and ophthalmological evaluation and collection of vitreous and aqueous material was 1 day in 36.66%, 2–7 days in 43.44%, 7–14 days in 10% and more than 15 days in 10% of patients; 66.66% had positive cultures. 11 patients had intraocular foreign body. One year after trauma, visual acuity was classified as no light perception (NLP) in 33.33%, light perception in 6.66%, hand motion in 13.33%, counting fingers in 13.33%, and better than 20/400 in 20% of patients. Considering presence of intraocular foreign body, initial visual acuity and symptoms onset time, only initial visual acuity showed as better prognostic factor in final visual acuity.

Conclusion
Endophthalmitis is a severe ocular inflammatory condition that may lead to irreversible vision loss. Initially only one patient had visual acuity of NLP, but after 1 year, 33% showed visual acuity of NLP, and only 20% had visual acuity better than 20/400, what is consistent with a severe infection with a guarded prognosis. The high incidence of endophthalmitis after ocular penetrant trauma justifies distinct treatment and greater attention.
Anodal tDCS over left parietal cortex expedites recovery from stroke-induced apraxic imitation deficits: a pilot study
Authors: Ant Jana M. , Niessen Eva , Achilles Elisabeth I. S. , Saliger Jochen , Karbe Hans , Weiss Peter H. , Fink Gereon R. 
Published: November 2019

Abstract
Background
To date, specific therapeutic approaches to expedite recovery from apraxic deficits after left hemisphere (LH) stroke remain sparse. Thus, in this pilot study we evaluated the effect of anodal transcranial direct current stimulation (tDCS) in addition to a standardized motor training on apraxic imitation deficits.

Methods
In a rehabilitation hospital, we assessed apraxic, aphasic, and motor deficits in 30 LH stroke patients before and after a five-day standard programme of motor training combined with either anodal (10 min, 2 mA; n = 14) or sham (10 min, 0 mA, n = 16) tDCS applied in a double-blind fashion over left posterior parietal cortex (PPC). Where appropriate, data were analyzed with either t-test, Fisher’s exact test, or univariate/ repeated measures ANOVA.

Results
Compared to sham tDCS, five sessions of anodal tDCS expedited recovery from apraxic imitation deficits (p < 0.05): Already after 5 days, the anodal tDCS group showed levels of imitation performance that were achieved in the sham tDCS group after 3 months. However, the primary outcome of the study (i.e., anodal tDCS induced improvement of the total apraxia score) failed significance, and there was no significant tDCS effect on apraxia after 3 months. Anodal tDCS improved grip force (of the contra-lesional, i.e., right hand), but had no effect on aphasia.

Conclusions
Data from this pilot study show that repetitive, anodal tDCS over left PPC combined with a standardized motor training expedites recovery from imitation deficits in LH stroke patients with apraxia (relative to sham stimulation). Results suggest that in patients suffering from apraxic imitation deficits a randomized controlled trial (RCT) is warranted that investigates the effects of tDCS applied over PPC in addition to a standardized motor training.
Indoor versus outdoor scene recognition for navigation of a micro aerial vehicle using spatial color gist wavelet descriptors
Authors: Ganesan Anitha , Balasubramanian Anbarasu 
Published: November 2019

AbstractIn the context of improved navigation for micro aerial vehicles, a new scene recognition visual descriptor, called spatial color gist wavelet descriptor (SCGWD), is proposed. SCGWD was developed by combining proposed Ohta color-GIST wavelet descriptors with census transform histogram (CENTRIST) spatial pyramid representation descriptors for categorizing indoor versus outdoor scenes. A binary and multiclass support vector machine (SVM) classifier with linear and non-linear kernels was used to classify indoor versus outdoor scenes and indoor scenes, respectively. In this paper, we have also discussed the feature extraction methodology of several, state-of-the-art visual descriptors, and four proposed visual descriptors (Ohta color-GIST descriptors, Ohta color-GIST wavelet descriptors, enhanced Ohta color histogram descriptors, and SCGWDs), in terms of experimental perspectives. The proposed enhanced Ohta color histogram descriptors, Ohta color-GIST descriptors, Ohta color-GIST wavelet descriptors, SCGWD, and state-of-the-art visual descriptors were evaluated, using the Indian Institute of Technology Madras Scene Classification Image Database two, an Indoor-Outdoor Dataset, and the Massachusetts Institute of Technology indoor scene classification dataset [(MIT)-67]. Experimental results showed that the indoor versus outdoor scene recognition algorithm, employing SVM with SCGWDs, produced the highest classification rates (CRs)—95.48% and 99.82% using radial basis function kernel (RBF) kernel and 95.29% and 99.45% using linear kernel for the IITM SCID2 and Indoor-Outdoor datasets, respectively. The lowest CRs—2.08% and 4.92%, respectively—were obtained when RBF and linear kernels were used with the MIT-67 dataset. In addition, higher CRs, precision, recall, and area under the receiver operating characteristic curve values were obtained for the proposed SCGWDs, in comparison with state-of-the-art visual descriptors.
Incidental findings in lumbar spine MRI: their prevalence and potential impact on patient management
Authors: Ibrahim Heba , Elsadawy Momena Essam Ibrahim 
Published: November 2019

Abstract
Background
To document the prevalence of extra spinal findings in lumbar MRI

Results
Among the scanned 400 patients, 90 cases had incidental non-spinal findings, and in 30 out of these 90 patients, the finding was the only reason for their complaint.

Conclusions
Radiologists should give attention to the non-spinal findings in lumbar spine MRI, as the detected pathology could be the source of pain or could potential life-threatening conditions.
Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma
Authors: Paiva Bruno , Puig Noemi , Cedena Maria-Teresa , Rosiñol Laura , Cordón Lourdes , Vidriales María-Belén , Burgos Leire , Flores-Montero Juan , Sanoja-Flores Luzalba , Lopez-Anglada Lucia , Maldonado Roberto , de la Cruz Javier , Gutierrez Norma C. , Calasanz Maria-Jose , Martin-Ramos Maria-Luisa , Garcia-Sanz Ramón , Martinez-Lopez Joaquin , Oriol Albert , Blanchard María-Jesús , Rios Rafael , Martin Jesus , Martinez-Martinez Rafael , Sureda Anna , Hernandez Miguel-Teodoro , de la Rubia Javier , Krsnik Isabel , Moraleda Jose-Maria , Palomera Luis , Bargay Joan , Van Dongen Jacques J.M. , Orfao Alberto , Mateos Maria-Victoria , Blade Joan , San-Miguel Jesús F. , Lahuerta Juan-José ,   on behalf of the GEM (Grupo Español de Mieloma)/PETHEMA (Programa Para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Group
Published: November 2019

PURPOSE Assessing measurable residual disease (MRD) has become standard with many tumors, but the clinical meaning of MRD in multiple myeloma (MM) remains uncertain, particularly when assessed by next-generation flow (NGF) cytometry. Thus, we aimed to determine the applicability and sensitivity of the flow MRD-negative criterion defined by the International Myeloma Working Group (IMWG). PATIENTS AND METHODS In the PETHEMA/GEM2012MENOS65 trial, 458 patients with newly diagnosed MM had longitudinal assessment of MRD after six induction cycles with bortezomib, lenalidomide, and dexamethasone (VRD), autologous transplantation, and two consolidation courses with VRD. MRD was assessed in 1,100 bone marrow samples from 397 patients; the 61 patients without MRD data discontinued treatment during induction and were considered MRD positive for intent-to-treat analysis. The median limit of detection achieved by NGF was 2.9 × 10−6. Patients received maintenance (lenalidomide ± ixazomib) according to the companion PETHEMA/GEM2014MAIN trial. RESULTS Overall, 205 (45%) of 458 patients had undetectable MRD after consolidation, and only 14 of them (7%) have experienced progression thus far; seven of these 14 displayed extraosseous plasmacytomas at diagnosis and/or relapse. Using time-dependent analysis, patients with undetectable MRD had an 82% reduction in the risk of progression or death (hazard ratio, 0.18; 95% CI, 0.11 to 0.30; P < .001) and an 88% reduction in the risk of death (hazard ratio, 0.12; 95% CI, 0.05 to 0.29; P < .001). Timing of undetectable MRD (after induction v intensification) had no impact on patient survival. Attaining undetectable MRD overcame poor prognostic features at diagnosis, including high-risk cytogenetics. By contrast, patients with Revised International Staging System III status and positive MRD had dismal progression-free and overall survivals (median, 14 and 17 months, respectively). Maintenance increased the rate of undetectable MRD by 17%. CONCLUSION The IMWG flow MRD-negative response criterion is highly applicable and sensitive to evaluate treatment efficacy in MM.