bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Continuous-Flow H–D Exchange Reaction of Aromatic Nuclei in D2O/2-PrOH Mixed Solvent in a Catalyst Cartridge Packed with Platinum on Carbon Beads
Authors: Park Kwihwan , Ito Naoya , Yamada Tsuyoshi , Sajiki Hironao 
Published: November 2020

Abstract
Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60 s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.
Could anaesthesia be a key factor for the good outcome of bone ablation procedures? A retrospective analysis of a musculoskeletal interventional centre
Authors: Arrigoni Francesco , Izzo Antonio , Bruno Federico , Zugaro Luigi , Arrigoni Giovanni , Vacca Francesco , Barile Antonio , Masciocchi Carlo 
Published: November 2020

Objective:
To choose the best anaesthetic approach through the retrospective review of different bone ablation procedures.

Methods and materials:
We retrospectively evaluated 118 ablation procedures carried out in our institute over the last 30 months. Three different anaesthetic approaches were used: general anaesthesia, i.v. sedation/analgesia and loco-regional anaesthesia (brachial plexus block, spinal anaesthesia). The outcomes were evaluated based on three parameters: technical success, patient comfort (Scale 1–5) and operator comfort (Scale 1–5).

Results:
The 118 interventional procedures were carried out on 62 benign and 56 malignant bone lesions. The overall procedural success rate was 100%. Three cases were treated under general anaesthesia: patient comfort was 5/5 in all cases; operator comfort was 5/5 in one case, and 4/5 in two cases. Twenty-one patients underwent sedation/analgesia: in three patients with benign bone lesions, patient comfort was 1/5 and operator comfort 3/5; in two patients with malignant bone lesions, patient comfort was 3/5 and operator comfort 4/5. Ninety-four patients underwent loco-regional anaesthesia: patient and operator comfort was 5/5 in all cases.

Conclusion:
Based on our experience, loco-regional anaesthesia is probably the best anaesthetic approach during bone ablation procedures. Benign bone lesions ablation are the more painful procedures.

Advances in knowledge:
This is the first paper that systematically investigates about the best anaesthesiological support for IR procedures.
Continuous research monitoring improves the quality of research conduct and compliance among research trainees: internal evaluation of a monitoring programme
Authors: Akello Mirriam , Coutinho Sarah , N-Mboowa Mary Gorrethy , Bukirwa Victoria D , Natukunda Agnes , Lubyayi Lawrence , Nabakooza Grace , Cose Stephen , Elliott Alison M. 
Published: November 2020

Background: Research site monitoring (RSM) is an effective way to ensure compliance with Good Clinical Practice (GCP). However, RSM is not offered to trainees (investigators) at African Institutions routinely. The Makerere University/Uganda Virus Research Institute Centre of Excellence in Infection and Immunity Research and Training (MUII-Plus) introduced internal monitoring to promote the quality of trainees’ research projects. Here, we share our monitoring model, experiences and achievements, and challenges encountered. Methods: We analysed investigators’ project reports from monitoring visits undertaken from April 2017 to December 2019. Monitors followed a standard checklist to review investigator site files and record forms, and toured site facilities. We planned four monitoring visits for each trainee: one at site initiation, two interim, and a closeout monitoring visit. A team of two monitors conducted the visits. Results: We monitored 25 out of the 26 research projects in progress between April 2017 and December 2019. Compliance with protocols, standard operating procedures, GCP, and GCLP improved with each monitoring visit. Median (IQR) compliance rate was 43% (31%, 44%) at site initiation visit for different monitoring items, 70% (54%, 90%) at the 1st interim monitoring visit, 100% (92%, 100%) at 2nd interim monitoring visit and all projects achieved 100% compliance at site closeout. All investigators had good work ethics and practice, and appropriate facilities. Initially, some investigators’ files lacked essential documents, and informed consent processes needed to be improved. We realized that non-compliant investigators had not received prior training in GCP/GCLP, so we offered them this training. Conclusions: Routine monitoring helps identify non-compliance early and improves the quality of research. We recommend continuous internal monitoring for all research studies. Investigators conducting research involving human subjects should receive GCP/GCLP training before commencing their projects. Institutional higher degrees and research ethics committees should enforce this as a requirement for project approvals.
ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol
Authors: O'Neill Linda , Guinan Emer , Doyle Suzanne L. , O'Connor Louise , Sheill Grainne , Smyth Emily , Fairman Ciaran M. , Segurado Ricardo , Connolly Deirdre , O'Sullivan Jacintha , Reynolds John V. , Hussey Juliette 
Published: November 2020

Background: Exercise rehabilitation programmes, traditionally involving supervised exercise sessions, have had to rapidly adapt to virtual delivery in response to the coronavirus disease 2019 (COVID-19) pandemic to minimise patient contacts. In the absence of an effective vaccine, the pandemic is likely to persist in the medium term and during this time it is important that the feasibility and effectiveness of remote solutions is considered. We have previously established the feasibility of the Rehabilitation Strategies following Oesophago-gastric Cancer (ReStOre) intervention - a face to face multidisciplinary rehabilitation programme for upper gastrointestinal (UGI) cancer survivors. This study will examine the feasibility of a virtually delivered 12-week multi-component ReStOre@Home programme. Methods: This single arm feasibility study will recruit 12 patients who have completed curative treatment for oesophago-gastric cancer. Participants will complete the 12-week ReStOre@Home programme consisting of exercise (aerobic and resistance training), 1:1 dietary counselling and group education sessions through virtual delivery. Underpinned by the Medical Research Council (MRC) Framework, feasibility will be determined by recruitment rates, adherence, retention, incidents, and acceptability. Acceptability will be assessed qualitatively through post-intervention interview and the Telehealth Usability Questionnaire. Secondary outcomes will be assessed pre and post-intervention and will include measures of physical performance (cardiopulmonary exercise test, short physical performance battery, hand grip strength, Godin Leisure Time Questionnaire, and body composition), health related quality of life (European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC-QLQ-C30) and oesophago-gastric cancer specific subscale (EORTC-QLQ-OG25), fatigue (Multidimensional Fatigue Inventory (MFI-20), and venous blood samples will be collected for the UGI Cancer Survivorship Biobank. Discussion: The ReStOre@Home feasibility study will provide important data regarding the amenability of a multidisciplinary programme designed for UGI cancer survivors to virtual delivery. Trial registration: ClinicalTrials.gov NCT04603339 (26/10/2020)
Impact of the first COVID-19 pandemic wave on the Scottish Multiple Sclerosis Register population
Authors: Fernandes Peter M. , O'Neill Martin , Kearns Patrick K.A. , Pizzo Sinforosa , Watters Chrissie , Baird Stuart , MacDougall Niall J.J. , Hunt David P.J. 
Published: November 2020

Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on people with multiple sclerosis (MS) is a major current concern, in particular the risk of death. Here we describe the impact of the first wave of COVID-19 infections (Mar 2020-July 2020) on the Scottish MS Register (SMSR) population, a cohort of 4702 individuals with MS, all newly diagnosed in the past decade. Methods: We established a clinician alert system, linking the SMSR with the Electronic Communication of Surveillance in Scotland (ECOSS). This allows identification of patients within this cohort who had a positive SARS-CoV-2 PCR test. The SMSR was also linked to death records from National Records Scotland. Results: Of 4702 people with MS, 246 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR tests were performed, of which 17 were positive. The proportion of positive tests were similar to the general Scotland population (Observed PCR confirmed cases = 17, expected = 17.5, O/E = 0.97, 95% CI: 0.60 – 1.56, p=.90). Between 1st March – 31st July 2020 12 individuals on the SMSR died, 5 of which were linked to COVID-19 (1 PCR confirmed, 4 clinical diagnoses without PCR confirmation). This number of COVID-19-related deaths was higher than expected (observed deaths = 5, expected deaths = 1.2, O/E = 4.03, 95% CI = 1.48 – 8.94, p=.01). All COVID-19-related deaths in the SMSR occurred in individuals with advanced disability (Expanded Disability Status Scale ≥7), and no deaths occurred in patients receiving disease modifying therapy (DMT) therapies. Conclusion: In this nationally comprehensive cohort of MS patients diagnosed in Scotland within the past 10 years, we observed similar rates of PCR-confirmed SARS-CoV-2 infection compared to the general Scottish population, but a small number of excess COVID-19 related deaths. These deaths occurred in individuals with advanced disability who were not receiving DMTs.
„Przekład jako doświadczenie obcego” w kontekście przekładów literatury fantasy
Authors: Pamięta‑Borkowska Joanna 
Published: November 2020

„The translation as the experience of the foreign” in the context of translations of fantasy literature
Translation as the experience of the foreign is understood either as the relation of what is domestic to the foreign or as an experience for the foreign itself. According to a thesis of Anton Popovič, the readers expect and want the translation to be a foreign product when viewed against the native works. On the ground of theoretical reflections of Popovič and Bergmann an attempt was made to show the propriety of occurrences of the foreign elements in Polish and Russian fantasy literature, and above all, the fulfillment of the intentions of the authors of original works in translation. Words and phrases that are connected with the occultism and folklore were analyzed, as well as elements of local dialects that contributed to specific vocabulary that create the flavor of characters. These are the elements of the presented world: names of nations, phenomena and objects, monsters and mythical beings. The mentioned elements were extracted from both the original and translated texts and examined for maintenance of the tone of the original. Afterwards a division was made into the elements preserved, dropped or changed in translation. The final conclusions relate to the intertextual tradition of the fantasy literature.
Hadżi Dimityr Christo Botewa – obce elementy kulturowe w polskich przekładach
Authors: Gołek‑Sepetliewa Dorota 
Published: November 2020

Hadzhi Dimitar by Hristo Botev – the foreign cultural elements in Polish translations
The famous poetic work by Bulgarian artist Christo Botev – the romantic ballad Hadzhi Dimitar is full of foreign cultural elements that are recognized by Polish readers. This poem is an important center in the Bulgarian national discourse, inspired by southslavic folklore, strongly influenced by the hajduk‑legend, it mythologizes important Bulgarian historical event (the death of Hadzhi Dimitar and Stefan Karadzha on Mount Buzludzha). The analysis and interpretation of the original text and two polish translations by Z. Wolnikówna and W. Broniewski, allow to answer the following questions: if translators are intermediaries and interpreters of the elements of a foreign culture? Which strategies are used by translators to effective communication between the Bulgarian and Polish cultures? Do translations give a fair and accurate representation of the original poem?
FLEXIBLE FORM OF EMPLOYMENT: PROSPECTS OF DEVELOPMENT
Authors: Barhatov Viktor , Kapkaev Yuner , Isaeva Anna 
Published: November 2020

The need for the study is justified by the development of flexible forms of employment in the economy with new job opportunities for the international division of labor. The paper analyzed new job opportunities and risks associated with flexible form of employment for the workers, employers and the state individually as well as in relation to each other. The study investigated the future prospects of flexible forms of employment along with its impact on the economic opportunities for the enterprises and workers and conclusion has been drawn. The impact of flexible employment was also investigated on the welfare of the population and the development of national economies in the context of globalization. Three forms of flexible employment: temporal flexibility, spatial flexibility and functional flexibility have been identified to achieve the research goal.
The prospects of flexible form of employment for the enterprise and employee were assessed based on the subjective approach. The rapid assessment and empirical analysis method were used to track the population dynamics and their interest in flexible forms of employment. The results show that the increase in the share of flexible employment in the economy is justified by the increased importance of creative labor in the labor market. Flexible workers represent a diverse population group in terms of the socio-economic structure. The active development of flexible forms of employment has been considered as a manifestation of the self-regulating economy and as a form of adaptation of the population to the changing socio-economic situation. The new agile business integration can reduce the costs of hiring a full-time employee and increases employees’ motivation level. The state needs to institutionalize new forms of employment in order to ensure the competitiveness of the national economy and to ensure budget revenues.
THE IMPACT FACTORS ON PROJECT MANAGEMENT SUCCESS IN GLOBAL TEAMS: THE CASE OF COMPANY “X” PROJECTS
Authors: Sluka Inese , Brence Sintija 
Published: November 2020

Nowadays, with globalization and the development of information technology, global teams are one of the fastest growing types of teams. Communication technology capabilities have significantly reduced the cost of team management and remote collaboration. Current management science has a broad theoretical basis for managing teams that are physically located in one place, but there is much less understanding of how leaders can effectively manage global teams.
Company X is a global management consulting, technology services and outsourcing company. All company projects have virtual teams and participants from different countries
The goal of this research is to identify and study the factors that influence the success of global project team management and operations in Company X.
The research provides answers to the following questions: 1) Which factors impact the project management success at global company X?; 2) What is the impact of a team member’s role and experience on project management success at company X?; 3) What are the cultural differences within the project teams?
The data was collected from a survey of two global teams (n=31) at global company X. Team members represent three cultures: Finnish, Indian and Latvian. The analyzed factors were communication, remote communication tools, roles and rules, and trust and cooperation in a multicultural environment. Communication, remote communication tools, and roles and rules showed a statistically significant impact on project management success in global teams. The current role of team members has a negative effect on project management success.
No statistically significant differences between cultures were found which supports Cultural Convergence Theory which suggests that two cultures will be more and more like each other as their interactions increase.
POOL WATER OVERCHLORINATION IN TIMIS COUNTY, ROMANIA: CASE-STUDY
Authors: Petrescu Cristina , Muntean Calin 
Published: November 2020

OBJECTIVE: The aim of the study conducted was to investigate residual chlorine concentrations in pool water from Timis County, Romania over two years (2016-2017).
MATERIAL OF STUDY consisted of a sample of 50 pools from Timis County from which were collected and analyzed 154 water tests.
THE METHOD was an observational inquiry (case-study) of the residual chlorine concentrations considering spatial and temporal distribution and comparing with actual standards (4 groups of residual chlorine concentrations were considered).
RESULTS: Average concentrations of residual chlorine exceeded 0,5mg/l in 30 investigated pools. Monthly mean concentrations of residual chlorine exceeded 0.5mg/l 20 of the 24 months of the investigation period. The maximum value of residual chlorine monthly mean concentration was recorded in July, 2017 and the highest average concentration at the pool I3. An Anova Oneway analysis indicated a statistically significant difference (F=30.312, Sig.0.000) between the 4 groups of residual chlorine concentrations: over 1.5 mg/l / (0-0.5mg/l, Sig.000; 0.5-1mg/l, Sig.0.001, 1-1.5mg/l, Sig.0.009).
CONCLUSION: There is an over-chlorination of pool water of Timis County, Romania, with spatial and temporal variation and statistically significant differences between groups of residual chlorine concentrations.
DIAGNOSTIC POSSIBILITIES OF ANALYSIS OF THE MAP OF LINEAR BIREFRINGENCE OF THE CRYSTAL FRACTION OF VITREOUS BODY FOR ACCURATE DETERMINATION OF THE TIME SINCE DEATH
Authors: Sarkisova Yuliia , Bachynskіy Viktor , Palamar Alina , Palibroda Nadya , Patratii Maryna 
Published: November 2020

Introduction: This paper discusses the possibility of polarization microscopic tomography of polycrystalline structure of vitreous body (VB) for use in forensics and in determining the time since death (TSD).
Objectives: The purpose of this study was to develop a new set of forensic criteria to enhance the functionality of the high-precision definition of TSD over a long period of time according to polarization microscopic tomography of the polycrystalline structure of the VB of the human eye by statistical and wavelet analysis.
Results: We obtained the numerical values of the change in the magnitude of the statistical moments of the 1-4 orders, which characterize the coordinate distributions of the magnitude of the linear birefringence (LB) of the polycrystalline component of the VB by the magnitude of the TSD. The results from our research illustrate the differences between the optical anisotropy of fibrillar collagen networks of VB layers with different TSD. The sensitivity range (36 hours) and accuracy (15 minutes) of the method of polarization tomography of the LB distributions of the polycrystalline component of the VB layers in the determined TSD were established.
Conclusion: These results confirm the experimental processes outlined accurately determine the time of death. In turn, will provide scientific evidence, specifications thereof, and objective expert opinion.
IMPACT OF ANXIETY AND TERROR OF DEATH ON QUALITY OF LIFE IN PATIENTS ON CHRONIC HEMODIALYSIS
Authors: Shevchuk-Kravchenko Olha , Penderetska Oksana , Garazdiuk Ivan , Garazdiuk Oleksandr , Bachynskiy Viktor 
Published: November 2020

The aim of the study was to identify the terror of death and anxiety level in patients with end-stage renal disease receiving renal replacement therapy using chronic hemodialysis (HD) and to evaluate the impact of patients' psychological status on medical staff, selection of basic methods of psychotherapeutic care for patients in this category. We involved 37 patients, aged 33-72 years (mean, 45.6 ± 3.8 years). The duration of chronic HD ranged from 8 months to 10 years, with an average of 4.6 years. All the patients had a stable nutritional status, HD regimen and drug therapy for at least 3 months. To diagnose the psychological state of patients we used: the scale of self-assessment of the level of situational and personal anxiety (Spielberger-Hanin’s Scale), personal questionnaire for changes at the onset of HD therapy, elements of a clinical interview, image apperception test (simplified version of Thematic apperception test., Bechterev’s Institute Personal Questionnaire for Diagnosis of Type of Illness (LOBI), Locus of control and personal changes after initiation of HD therapy.
We found that the: adaptation of the patient to HD therapy is complicated due to the high degree of anxiety and maladaptive terror of death, which reduce the patient’s quality of life. The HD procedure increases the level of situational anxiety and requires psycho-correction. HD therapy requires activation of the patient's psychological protection mechanisms, since the dominant protective mechanisms of the psyche in this type of substitution treatment are displacement and negation. The inflexible and rigid use of the latter provokes maladaptive reactions when interacting with healthcare providers, a non-constructive approach to lifestyle choices, work-rest regime, and diet. Patients with a maladaptive mode of adjustment to HD therapy require psychotherapy assistance. There is a need to monitor the psychological status of not only patients, but also medical staff, which due to the specificity of the contingent increases the level of contingent own terror of death. Doctors of HD units require participation in mutual support groups.