bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole genome sequence analysis of Cupriavidus campinensis S14E4C, a heavy metal resistant bacterium
Authors: Abbaszade Gorkhmaz , Szabó Attila , Vajna Balázs , Farkas Rózsa , Szabó Csaba , Tóth Erika 
Published: May 2020

AbstractCupriavidus sp. are model organisms for heavy metal(loid) resistance and aromatic compound’s degradation studies and these characteristics make them a perfect candidate for biotechnological purposes. Bacterial strain S14E4C (identified as Cupriavidus campinensis) was isolated from a playground by enrichment method in a 0.25 mM containing medium. The analysis revealed that this bacterium is able to tolerate high concentrations of heavy metal(loid)s: Cd up to 19.5 mM, Pb to 9 mM, Hg to 5.5 mM and As to 2 mM in heavy metal(loid) salt containing nutrient medium. The whole genome data and analysis of the type strain of C. campinensis CCUG:44526T have not been available so far, thus here we present the genome sequencing results of strain S14E4C of the same species. Analysis was carried out to identify possible mechanisms for the heavy metal resistance and to map the genetic data of C. campinensis. The annotation pipelines revealed that the total genome of strain S14E4C is 6,375,175 bp length with a GC content of 66.3% and contains 2 plasmids with 295,460 bp (GC content 59.9%) and 50,483 bp (GC content 63%). In total 4460 coding sequences were assigned to known functions and 1508 to hypothetical proteins. Analysis proved that strain S14E4C is having gene clusters such as czc, mer, cus, chr, ars to encode various heavy metal resistance mechanisms that play an important role to survive in extreme environments.
A Mineralogical Investigation of Sintering in Cu-Rich Polymetallic Concentrates During Roasting in Inert Atmosphere
Authors: Prasad Pande Nishant , Lennartsson Andreas , Samuelsson Caisa 
Published: May 2020

Abstract
Four different Cu-rich polymetallic concentrates (additionally comprising Zn, Pb and impurity elements As, Sb) from various deposits in Sweden are examined, in particular for the sintering tendency during roasting in inert atmosphere. Experiments performed in a laboratory-scale roasting setup between 200 °C and 700 °C in intervals of 100 °C revealed that significant sintering initiates from 500 °C for all four concentrates. Two sintering mechanisms are determined from the examination of the sintered calcines: (1) solid-state assimilation of Cu-, Zn- and Fe-bearing main sulphide minerals to form a high-temperature solid solution, the iss phase belonging to the Cu-Fe-Zn-S system; (2) low-melting liquid phase formation due to partial melting of galena facilitated by the presence of impurity-bearing minerals, mainly the arsenopyrite and Sb sulphosalts such as tetrahedrite. Galena also forms a melt below 700 °C with the iss phase. Therefore, the presence of galena in polymetallic concentrates generally increases the susceptibility to early sintering. These experiments in inert atmosphere facilitate a fundamental study with practical relevance to the roasting in low oxidation potential environments, favourable for volatilization of impurity elements such as As and Sb.
A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs)
Authors: Adamiak Mateusz , Cymer Monika , Anusz Krzysztof , Tracz Michał , Ratajczak Mariusz Z. 
Published: May 2020

AbstractDelayed homing and engraftment of hematopoietic stem progenitor cells (HSPCs) or even failure to engraft at all is significant clinical problem after hematopoietic transplant. Therefore, in order to develop more efficient homing and engraftment facilitating strategies it is important to learn more about this process. Our team has postulated that myeloablative conditioning for transplantation induces in bone marrow (BM) microenvironment a state of sterile inflammation in which elements of innate immunity activated by radio- or chemotherapy conditioning for transplant play an important role. In frame with this claim we reported that a significant role in this process plays activation of complement cascade (ComC). Accordingly, mice that that lack a fifth component (C5) of ComC turned out to engraft poorly with normal syngeneic BM cells as compared to normal control animals. In extension of our previous studies we provide for first time evidence that mannan binding lectin (MBL) pathway is involved in activation of ComC in myeloablated transplant recipient BM and thus plays an important role in homing and engraftment of HSPCs. To support this MBL-KO mice show significant defect in hematopoietic reconstitution after hematopoietic transplantation. This correlates with a decrease in expression of stromal derived factor-1 (SDF-1) and impaired activation of Nlrp3 inflammasome in irradiated BM of these mice.
Long-term Effects of a Mindfulness-Based Childbirth and Parenting Program—a Randomized Controlled Trial
Authors: Lönnberg Gunilla , Jonas Wibke , Bränström Richard , Nissen Eva , Niemi Maria 
Published: May 2020

Abstract
Objectives
The aim of the present study was to investigate long-term effects of Mindfulness-Based Childbirth and Parenting (MBCP) during pregnancy on women’s perceived stress and depressive symptoms during the first year postpartum.

Methods
Women (n = 193) who were pregnant with their first child and at risk for perinatal depression were randomized to MBCP or an active control condition, which consisted of a Lamaze childbirth class. The women provided self-reported data on perceived stress, depressive symptoms, positive states of mind, and the Five Facets of Mindfulness Questionnaire at baseline, postintervention, and at 3, 9, and 12 months postpartum.

Results
Linear mixed model analysis showed that the intervention group had a larger decrease in stress (p = 0.04) and depression scores (p = 0.004) and larger increase in positive states of mind (p < 0.001) and mindfulness scores (p < 0.001) from baseline to postintervention (10–12 weeks later), compared with the active control group. These initial effects were not sustained during the follow-up period. However, analyses restricted to mothers in the MBCP condition showed that those who reported continued mindfulness practice during the follow-up period (n = 50) had a greater initial effect of the intervention and sustained the effects to a larger degree, compared with mothers who did not continue practicing mindfulness (n = 21).

Conclusions
This study gives partial support for providing MBCP for pregnant women. Although the initial beneficial effects from MBCP were not sustained during the postpartum period, the findings warrant further investigations since the improvements take place in a time that is crucial for the mother–infant dyad.

Trial Registration
ClinicalTrials.gov ID: NCT02441595.
Carotenoids: Potent to Prevent Diseases Review
Authors: Bhatt Takshma , Patel Kirtan 
Published: May 2020

AbstractCarotenoids are the phytochemicals known for their biological activities. They are found in nature in the form of plants, algae, fungi and in microorganisms. This is the major group having two different structure one with oxygen and without oxygen. The Present article aims to present these molecules as a new therapeutic agent, as it has unrealized efficiency to prevent and reduce the symptoms of many diseases like cancer, neurodegenerative diseases such as Alzheimer, cerebral ischemia, diabetes associated with obesity and hypertension, ophthalmic diseases and many more. It can be utilized in the form of dietary supplement as nutraceutical and pharmaceutical compounds. Yet more research and developing test knowledge is needed to make it available to the humans. In this article its sources, biosynthesis, properties, applicability and commercialization of pigments from naturally produced sources are discussed.
Graphic Abstract
Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry
Authors: Mörkl Sabrina , Butler Mary I , Holl Anna , Cryan John F , Dinan Timothy G 
Published: May 2020

Abstract
Purpose of Review
Probiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gut microbes are suggested to play a role in many psychiatric disorders and could be a potential therapeutic target. Between the gut and the brain, there is a bi-directional communication pathway called the microbiota-gut-brain axis. The purpose of this review is to examine data from recent interventional studies focusing on probiotics and the gut-brain axis for the treatment of depression, anxiety and schizophrenia.

Recent Findings
Probiotics are likely to improve depression but not schizophrenia. Regarding anxiety, there is only one trial which showed an effect of a multispecies probiotic. However, determinants like the duration of treatment, dosage and interactions have not been thoroughly investigated and deserve more scientific attention.

Summary
Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis.
Laser transmission welding of absorber-free semi-crystalline polypropylene by using a quasi-simultaneous irradiation strategy
Authors: Nguyen Nam-Phong , Behrens Stefan , Brosda Maximilian , Olowinsky Alexander , Gillner Arnold 
Published: May 2020

AbstractUnlike other joining techniques, laser transmission welding offers unique advantages such as selective and contactless energy deposition. This enables the fabrication of flexible seam geometries at low mechanical and thermal stresses. However, the use of absorbing additives for the lower joining partner such as carbon black is crucial as most polymers are transparent in the spectral range of typical beam sources (800–1100 nm). A novel approach is the application of beam sources emitting radiation within the polymeric intrinsic absorption bands between 1500 and 2000 nm. This enables absorber-free laser welding of transparent polymers for medical or microfluidic applications such as Lab-on-a-Chip devices. The main drawback on the other hand is the large heat affected zone (HAZ) due to the volume absorption which is extending over the entire cross section. A possible way to overcome this disadvantage is a quasi-simultaneous irradiation strategy. It could be proved in the past that the HAZ of polycarbonate (PC) can be reduced in the vertical direction by up to 30% compared with contour welding. Since the effects of light scattering on the absorber-free quasi-simultaneous irradiation strategy are still unknown, the beam propagation was simulated in polypropylene (PP). Based on the results, a thermal simulation of the welding process was carried out using the finite element method (FEM). The simulation model was then evaluated by comparing the results with experimental trials.
Effect of increased yield strength, R-ratio, and plate thickness on the fatigue resistance of high-frequency mechanical impact (HFMI)–treated steel joints
Authors: Leitner M. , Barsoum Z. 
Published: May 2020

AbstractIn 2016, the International Institute of Welding (IIW) published a recommendation for high-frequency mechanical impact (HFMI) treatment for improving the fatigue strength of welded joints. Since the publication of the HFMI recommendations, numerous of studies have been published with a considerable amount of new fatigue test data focusing on various aspects of the improvement; influence of base material yield strength, and loading and thickness effects. Since the data was scarce covering some of the aspects when the recommendation was published, re-evaluating the recommendation with these new test data, presented within this work, will further validate and extend the recommendations. The analysis reveals that the recommended improvement of fatigue classes based on the base material yield strength is well applicable. In addition, the reduction of fatigue classes for higher R-ratios up to the defined value of R = 0.52 is well considered. Finally, the practicability of the thickness correction factor is also confirmed by leading to a conservative fatigue assessment. The ratio of the statistically evaluated FAT class to the recommended value is shown to be conservative with a value of above one for almost every data set; however, even the ratio is below one in some minor cases, every single test data point in this study is assessed conservatively validating the applicability of the recommendation.
Kinetic separation of CO2/CH4 mixtures with Ni-MOF-74@Al2O3 core–shell composites
Authors: Otter D. , Ernst S.-J. , Krätz L. , Bart H.-J. 
Published: May 2020

AbstractA novel core–shell species for the adsorption-based separation of carbon dioxide (CO2) from methane (CH4) is introduced by hydrothermal synthesis of Ni-MOF-74 on mesoporous spherical Al2O3 carrier substrate. The material was characterized and the shell thickness determined by means of optical and scanning electron microscopy as well as volumetric adsorption and fluid displacement experiments. Kinetic experiments with Ni-MOF-74@Al2O3 core–shell composites carried out at 303.15 K and at pressures up to 10 bar expose remarkably dominating uptake rates for CO2 over CH4. In the contrary Ni-MOF-74@Al2O3 appears to be unselective according to equilibrium data at the same conditions. Dynamic breakthrough experiments of binary CH4/CO2-mixtures (at 303.15 K and 5 bar) prove the prevailing effect of adsorption kinetics and the storage function of the mesoporous core. This statement is supported by a considerable boost in CO2-selectivity and capacity compared to adsorption equilibria measured on pure Ni-MOF-74 by the factor of 55.02 and up to 2.42, respectively.
The longitudinal associations among perceived discrimination, social initiative, and depressive symptoms in Chinese rural left‐behind adolescents☆
Authors: Zhao Jingxin , Wang Qian , Xue Xiangjuan 
Published: May 2020

ABSTRACTIntroductionPerceived discrimination is a significant stressor in the lives of Chinese rural left‐behind adolescents. Although some research has examined the effects of perceived discrimination on left‐behind adolescents’ psychosocial functioning, the majority of existing research is cross‐sectional, which limits the understanding of the underlying mechanism of these effects. The current study used a longitudinal design to explore how perceived discrimination is associated with psychosocial functioning (i.e., depressive symptoms and social initiative) over time in Chinese rural left‐behind adolescents.MethodsA total of 1011 rural left‐behind adolescents (54% boys) were involved in an ongoing longitudinal study. At Time 1 (Mage = 12.93, SD = 0.86), adolescents completed measures of perceived discrimination, depressive symptoms, and social initiative. At Time 2 (one year later), adolescents again reported on their depressive symptoms and social initiative.ResultsPerceived discrimination was concurrently and longitudinally associated with left‐behind adolescents’ depressive symptoms and social initiative. The effect of perceived discrimination on depressive symptoms was partially mediated by social initiative, while the effect of perceived discrimination on social initiative was fully mediated by depressive symptoms. The associations applied equally to adolescents with two migrant parents and adolescents with only a migrant father.ConclusionsThese findings suggest the harmful impact of perceived discrimination on rural left‐behind adolescents' social initiative and depressive symptoms and underscore the importance of eliminating discrimination in the rural left‐behind adolescents’ intervention program.
Synthetic photometric landmarks used for absolute navigation near an asteroid
Authors: Knuuttila O. , Kestilä A. , Kallio E. 
Published: May 2020

AbstractThe need for autonomous location estimation in the form of optical navigation is an essential requirement for forthcoming deep space missions. While crater-based navigation might work well with larger bodies littered with craters, small sub-kilometer bodies do not necessarily have them. We have developed a new pose estimation method for absolute navigation based on photometric local feature extraction techniques thus making it suitable for missions that cannot rely on craters. The algorithm can be used by a navigation filter in conjunction with relative pose estimation such as visual odometry for additional robustness and accuracy. To estimate the position and orientation of the spacecraft in the asteroid-fixed coordinate frame, it uses navigation camera images in combination with other readily available information, such as orientation relative to the stars and the current time for an initial estimate of the asteroid rotation state. Evaluation of the algorithm when using different feature extractors is performed, on one hand, using Monte Carlo simulations and, on the other hand, using actual images taken by the Rosetta spacecraft orbiting the comet 67P/Churyumov–Gerasimenko. Our analysis, where four different feature extraction methods (AKAZE, ORB, SIFT, SURF) were compared, showed that AKAZE is most promising in terms of stability and accuracy.
LO46: Prognostic value of single serum progesterone in the evaluation of symptomatic pregnant patients: a systematic review and meta-analysis
Authors: Ghaedi B. , Ameri S. , Abdulkarim K. , Thiruganasambandamoorthy V. 
Published: May 2020

Introduction: Pain and bleeding complicate 30% of pregnancies threatening viability. The objective of this systematic review is to evaluate the role of a single progesterone level in predicting viability. Methods: We comprehensively searched MEDLINE, Embase (OVID), CINAHL and Cochrane databases from inception to July 2019. We included English language studies that enrolled symptomatic first trimester pregnant patients, measured progesterone and reported viability (miscarriage, ectopic or viable). We excluded studies with patients who had progesterone treatment, or conception after induced ovulation/invitro fertilization. We extracted patient characteristics, study setting, mean progesterone, the cut off value and outcome (viability). The quality of the included studies was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. We extracted data for 2X2 tables and report mean, standard deviation (SD), sensitivity, specificity, positive and negative predictive values (PPV, NPV). Results: Of the 689 studies screened, 51 studies with 15783 patients were included (1 randomized control trial, 36 prospective, 9 retrospective, 5 prospective case control studies) and 7553 were viable pregnancies. Of the 31 studies (n = 10998) that reported ectopic, 1661 patients were diagnosed with ectopic pregnancy. In 35 studies (n = 6003) that reported mean and SD, the levels were higher in viable (26.7 ± 11.2ng/ml) than non-viable (9.5 ± 5.9ng/ml; p < 0.001) or ectopic pregnancy 9.5 ± 6.8ng/ml (p < 0.001). The pooled diagnostic characteristics at different cut-off values were: <6.3ng/mL (9 studies; N = 6033) sensitivity 65.0% (95%CI 63.5,66.5), specificity 97.3% (95%CI 95.5, 98.5), PPV 99.4% (95%CI 99.1,99.7) and NPV 27.4 (95%CI 26.6,28.4); <10 ng/mL (12 studies with 5743 participants) sensitivity 65.0% (95% CI 63.5, 66.5), specificity of 97.3% (95%CI 95.5, 98.5), PPV 99.4% (95% CI 99.1, 99.7) and NPV 27.4% [95% CI 26.5, 29.4); 11-20 ng/mL (24 studies with 7141 participants) sensitivity 77.3% (95% CI 76.2,78.4), specificity 64.6% (95% CI 63.2, 65.9), PPV 73.2% [95% CI 72.3, 73.9) and NPV 69.5% (95% CI 70.7, 72.5). There was low risk of bias for patient selection, index test and low concern regarding applicability. The highest risk (82% of studies) was due to outcome ascertainment bias due to non-blinding of index and additional tests. Conclusion: A single progesterone value is useful in predicting viability of pregnancy among symptomatic patients.
LO52: Distraction in the ED using Virtual reality for Intravenous Needs in Children to Improve comfort- DEVINCI - a pilot RCT
Authors: Trottier E. D. , Osmanlliu E. , Bailey B. , Lagacé M. , Certain M. , Khadra C. , Sanchez M. , Thériault C. , Paquin D. , Cotes-Turpin C. , Le May S. 
Published: May 2020

Introduction: Venipuncture is a frequent cause of pain and distress in the pediatric emergency department (ED). Distraction, which can improve patient experience, remains the most studied psychological intervention. Virtual reality (VR) is a method of immersive distraction that can contribute to the multi-modal management of procedural pain and distress. Methods: The main objectives of this study were to determine the feasibility and acceptability of Virtual Reality (VR) distraction for pain management associated with venipunctures and to examine its preliminary effects on pain and distress in the pediatric ED. Children 7-17 years requiring a venipuncture in the pediatric ED were recruited. Participants were randomized to either a control group (standard care) or intervention group (standard of care + VR). Principal clinical outcome was the mean level of procedural pain, measured by the verbal numerical rating scale (VNRS). Distress was also measured using the Child Fear Scale (CFS) and the Procedure Behavior Check List (PBCL) and memory of pain using the VNRS. Side effects were documented. Results: A total of 63 patients were recruited. Results showed feasibility and acceptability of VR in the PED and overall high satisfaction levels (79% recruitment rate of eligible families, 90% rate of VR game completion, and overall high mean satisfaction levels). There was a significantly higher level of satisfaction among healthcare providers in the intervention group, and 93% of those were willing to use this technology again for the same procedure. Regarding clinical outcomes, no significant difference was observed between groups on procedural pain. Distress evaluated by proxy (10/40 vs 13.2/40, p = 0.007) and memory of pain at 24 hours (2.4 vs 4.2, p = 0.027) were significantly lower in the VR group. Venipuncture was successful on first attempt in 23/31 patients (74%) in the VR group and 15/30 (50%) patients in the control group (p = 0.039). Five of the 31 patients (16%) in the VR group reported side effects Conclusion: The addition of VR to standard care is feasible and acceptable for pain and distress management during venipunctures in the pediatric ED. There was no difference in self-reported procedural pain between groups. Levels of procedural distress and memory of pain at 24 hours were lower in the VR group.