bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Practice and Associated Factor of Trachoma Transmission and Prevention Among Primary School Students in Addis Zemen Town, South Gondar, Northwest Ethiopia
Authors: Yirdaw Getasew , Tegegne Eniyew 
Published: December 2024

Background: Trachoma is the leading infectious cause of blindness worldwide, particularly impacting the poorest nations, including Ethiopia. Objective: To assess knowledge, practice, and associated factors of trachoma transmission and prevention among primary school students in Addis Zemen town, South Gondar, Northwest Ethiopia, 2022. Methods: An institution-based cross-sectional study was conducted on 407 randomly selected primary school students (grades 5-8), aged 10 to 24 years. Data collection included face-to-face interviews using structured questionnaires and an observation checklist. Epi-data version 4.2.0.0 and SPSS version 20 were used to enter and analyze the collected data, respectively. The data were analyzed using the descriptive statistical method and using bivariable and multivariable logistic regression models. Variables with a P-value <.05 with a 95% CI were considered to have statistical significance. Result: The study has a response rate of 98.25%, with a total of 400 respondents. 74.00% of the respondents knew about trachoma transmission and prevention, and 71.50% practiced preventive measures, such as face washing. Respondents in Grades 7 and 8, aged 12 to 24 years (AOR: 2.67, 95% CI: 1.93, 4.64), information about trachoma (AOR: 2.30, 95% CI: 1.56, 4.21), and urban residence (AOR: 3.42, 95% CI: 2.56, 5.23) were determinants of knowledge regarding trachoma transmission and prevention. Meanwhile, the mother’s occupation (government employee) (AOR: 2.50, 95% CI: 1.83, 6.91) and overall knowledge about trachoma (AOR: 4.87, 95% CI: 2.95, 8.53) were significant predictors of the practice of trachoma transmission prevention. Conclusion: While the level of knowledge and practice regarding trachoma transmission and prevention was relatively high, 26.00% of respondents still lacked adequate knowledge, and 28.50% did not practice prevention measures. To reduce the spread of trachoma and enhance public health outcomes, targeted interventions focusing on education about transmission and prevention strategies such as promoting face washing and proper sanitation should be prioritized in this area.
Characteristics of Intravenous Fluid Infiltration and Factors Associated With Adverse Events: A Multicenter Retrospective Study
Authors: Duggan Jessica L. , Lechtig Aron , Watkins Ian T. , Lans Jonathan , von Keudell Arvind , Zhang Dafang 
Published: December 2024

Background: Peripheral intravenous (PIV) infiltration and extravasation are common complications of intravenous fluid administration. Here, we aim to investigate risk factors associated with major adverse events following PIV infiltration, which may help risk stratify those who require early surgical consultation. Methods: Retrospectively, patients were identified who had a documented PIV infiltration or extravasation event at 3 academic hospitals between 2015 and 2022. A major adverse advent was defined as a full-thickness injury requiring operative management (deep infection, compartment syndrome). A minor adverse event was defined as superficial injury (cellulitis, superficial thrombosis). Results: In total, 160 patients with PIV infiltration events were included (37.5% men), with an average age of 64.1 years. A surgical consult for a hand specialist was placed 35% of the time: orthopedic surgery in 46.4% of cases and plastic surgery in 42.9%. Among these consults, 87.5% recommended supportive treatment (elevation, warm/cold compresses, serial examinations). Major adverse events occurred in 4.4% (n = 7) of patients, and minor adverse events occurred in 11.3% (n = 18). Both intensive care unit (ICU) admission and current intubation status (ie, intubated, sedated, and nonexaminable) at the time of infiltration were significantly associated with adverse events ( P = .02 and P = .03, respectively). Current intubation status was significantly associated with operative management ( P = .001). Conclusion: Robust characterization of PIV infiltration events may facilitate early identification of patients at risk of serious complications. We found ICU admission and current intubation both to be associated with adverse events following PIV infiltration. Further work should be done to evaluate the risk of infiltration with different fluid types (vesicant, nonvesicant).
Random forest algorithm identifies miRNA signatures for breast cancer detection and classification from patient urine samples
Authors: Maurer Jochen , Rübner Matthias , Kuo Chao-Chung , Klein Birgit , Franzen Julia , Wittenborn Julia , Kupec Tomas , Najjari Laila , Fasching Peter , Stickeler Elmar 
Published: December 2024

Background and objectives: Breast cancer is the most common cancer in women, with one in eight women suffering from this disease in her lifetime. The implementation of centrally organized mammography screening for women between 50 and 69 years of age was a major step in the direction of early detection. However, the participation rate reaches approximately 50% of the eligible women, one reason being the painful compression of the breast, cited as a major issue for not participating in this very important program. Therefore, focusing current research on less painful and less invasive techniques for the detection of breast cancer is highly clinically relevant. Liquid biopsies offer this option by detection of distinct molecules such as microRNAs (miRNAs) or circulating tumor DNA (ctDNA) or disseminated tumor cells. Design and methods: Here, we present the first proof-of-concept approach for sequencing miRNAs in female urine to detect breast cancer and, subsequently, intrinsic subtype-specific miRNA patterns and implement in this regard a novel random forest algorithm. To this end, we performed miRNA sequencing on 82 urine samples, 32 samples from breast cancer patients (9× luminal A, 8× luminal B, 9× triple-negative, and 6× HER2) and 50 healthy control samples. Results and conclusion: Using a random forest algorithm, we identified a signature of 275 miRNAs that allows the detection of invasive breast cancer in urine. Furthermore, we identified distinct miRNA expression patterns for the major intrinsic subtypes of breast cancer, specifically luminal A, luminal B, HER2-enriched, and triple-negative breast cancer. This experimental approach specifically validates miRNA sequencing as a technique for breast cancer detection in urine samples and opens the door to a new, easy, and painless procedure for different breast cancer-related medical procedures such as screening but also treatment monitoring.
Physico-Chemical Characterization, Biological Attributes and Sensory Evaluation of Commercial Ketchup
Authors: Hassan Qamar Ul , Sarfraz Raja Adil , Mohsin Muhammad , Iqbal Munawar , Ahmad Naveed , Al-Mijalli Samiah H. , Mnif Wissem , Nazir Arif , Iqbal Shahid 
Published: December 2024

Objectives/methodology The present study focuses on the evaluation of antioxidant potential (AP), total phenolic (TP) and total flavonoid (TF), antimicrobial activity (AA), antidiabetic capacity (AC), heavy metals contents (HMC) and sensory evaluation of commercial ketchup samples. Results The AP, TP and TF were found to be in the range of 35.51 to 77.92%, 2.66 to 14.98 mg GAE/100 g and 1.69 to 4.23 mg QE/g, respectively. The results of AA showed that commercial ketchup (CK) samples showed inhibition of microbial growth ranged from 18.96 to 30.67 mm against Staphylococcus aureus (S. aureus) and 19.00 to 31.14 mm against Escherichia coli (E. coli). The AC (involving alpha-amylase assay) was determined and represented as IC50 value of 23.12 to 62.76 µg/mL. According to the sensory evolution, all the samples were acceptable for use with overall acceptability <50. Conclusions The current study concluded that ketchup exhibited good antioxidant, antimicrobial and antidiabetic potential, however, the level of heavy metals in tested ketchup were required to be controlled.
Primary Care Providers Barriers, Comfort and Awareness in Follow-up Care of Acute Kidney Injury Patients: A Comprehensive Survey on Current Practices
Authors: Côté Jean-Maxime , Beaubien-Souligny William , Hamel Lauriane , Bouchard Josée 
Published: December 2024

Background: Patients who experienced acute kidney injury (AKI) may benefit from dedicated care following hospital discharge. Most of these patients will be followed by primary care providers. There is a lack of data on current practices and comfort for these care providers when offering post-AKI care. Objective: We surveyed nurse practitioners and family physicians to assess their awareness, perceptions, practice patterns and comfort regarding post-AKI care. Design/Setting: We distributed a web-based self-administered survey among clinicians from the Province of Quebec. We asked about their awareness and perceptions on how AKI should be disclosed and followed, the barriers encountered regarding the process of care following hospital discharge, and their level of comfort and expertise in offering dedicated post-AKI care. The survey integrated direct and scenario-based questions and was conducted from December 2022 to April 2023. Participants: We distributed the survey to practicing family physicians and nurse practitioners through the mailing list of the Fédération des Médecins Omnipraticiens du Québec, and the Association des infirmières praticiennes spécialisées du Québec, respectively. No incentives were provided. Methods: We conducted descriptive analyses and used chi-squared analysis to compare responses between family physicians and nurse practitioners and between hospital-based and cabinet-based practice. Results: The survey was opened by 779 potential participants. Of these, the response rate was 9% (70/779). Most participants were family physicians (79%) and dedicated 70% (±32) of their time in community outpatient clinics. Participants reported that 59% (±20) of all patients seen daily had at least 1 risk factor for AKI, whereas they estimated that 21% (±12) of recently discharged patients suffered from an AKI episode. The lack of awareness by the patient and lack of details on the discharge summary were the barriers most frequently reported impacting the overall process of care at follow-up. Most nurse practitioners (60%) and 33% of family physicians reported at least some levels of discomfort and lack of expertise when offering post-AKI. Limitations: The generalizability of our study is limited by its response rate. However, this is comparable with typical response rates seen in electronic surveys. The distribution was limited to a single province of Canada. Conclusions: We reported significant barriers regarding the hospital-to-community transition of care in patients who experienced AKI and the suboptimal comfort and expertise of primary care providers when offering dedicated post-AKI care. This reflects the need to improve communication, collaboration, and AKI training with primary care providers.
TikTok as a potential patient educational tool for thyroid-associated ophthalmopathy: A cross-sectional study
Authors: Wang Yue , Yang Shuo , Shu Xingyi , Chen Yuqing , Wei Ruili 
Published: December 2024

Objective Thyroid-associated ophthalmopathy (TAO) is a prevalent orbital disease significantly affecting patients’ daily lives. Nowadays, TikTok acts as a novel tool for healthcare but involved videos need to be further assessed. Many individuals search for disease information on TikTok before professional consultation. This study aimed to assess the quality of TAO-related TikTok videos and correlations between video variables and quality. Methods The top 150 TikTok videos were collected using the keyword TAO. Duplicate, too-short, irrelevant videos and similar videos from the same source were excluded. Two raters evaluated the included videos’ overall quality, reliability, understandability, and actionability on different sources and content focuses. Results Ninety videos had received nearly 15,000 likes and 2000 shares. Ophthalmologists and treatment focus were two primary parts among categorized groups, whose quality scores were much higher than others. The average Patient Education Materials Assessment Tool for Audiovisual Materials scores, Global Quality Scores, and DISCERN scores indicated that these videos were easy to understand (87.6%), actionable (74.5%), and fair in quality (44.97). The number of added hashtags was an essential variable positively correlated with video understandability. Additionally, popularity showed negative correlations with the overall quality, while video length positively correlated with its reliability and negatively correlated with the uploaded days. Conclusion Certified healthcare professionals uploaded most TAO videos, resulting in acceptable quality with minimal misinformation. To serve as a qualified source of patient educational materials, TikTok is supposed to promote longer disease-related videos and enhance reliability and understandability simultaneously.
A comparative study of patient–physician empathy in telehealth and traditional in-person visits
Authors: Jabour Abdulrahman M 
Published: December 2024

Background The rise of telemedicine has brought significant changes to patient care, especially regarding the experience of empathy and connection during consultations. Understanding how telemedicine compares to in-person visits in terms of patient–physician interactions and the perception of empathy is crucial for optimizing telehealth services. Objectives This study aims to compare patient–physician interaction ratings between telemedicine and in-person visits across the 10 items of the Consultation and Relational Empathy (CARE) measure. Additionally, it seeks to identify any significant differences in interaction ratings between male and female patients within these contexts. Methods A cross-sectional study was conducted involving 320 participants who had either telemedicine or in-person consultations. Participants were assigned to the telehealth or in-person group based on the type of consultation they experienced. The CARE measure was utilized to capture patient's perspective of the quality of the interaction. Statistical analyses were performed to compare the ratings between the two groups. Results The study found no significant differences in overall CARE measure ratings between telemedicine and in-person visits. However, male patients reported higher satisfaction with telemedicine on several items compared to in-person visits, whereas female patients showed no significant differences in their ratings. Conclusions Telemedicine is as effective as in-person visits in maintaining high-quality patient–physician interactions. The findings also suggest gender-specific preferences that could inform the optimization of telemedicine practices. Further research is recommended to explore these differences in more diverse populations.
Application of Management Accounting Tools and Enterprise Value Creation Based on the Value Chain
Authors: Sha XiuJuan 
Published: December 2024

Management accounting is an important technical and methodological system embedded in organizations for predicting variability and making business decisions, and it plays a positive role in promoting enterprise value creation. This study examined the influence of the application of management accounting tools on enterprise value creation from a value chain perspective. Data were obtained from a questionnaire survey, and hypothesis testing was conducted using structural equations. The research results show that the application of different management accounting tools in different links of the value chain have different impact on the value creation of the company’s internal operations and the enterprise customers. There is a significant positive correlation between value creation in Internal operation, value creation in customers, and value creation in finance. JEL Classification Numbers: J31, J41, J71.
Does Intra-Operative Methylprednisolone Improve Outcomes of Surgery for Degenerative Cervical Myelopathy? - A Prospective Randomized Study
Authors: Basu Saumyajit , Gohil Kushal , Singh Sanjit , Biswas Amitava , Sarangi Trinanjan , Palit Mainak 
Published: December 2024

Study design Randomized controlled trial. Objectives In this study, we hypothesize administering fixed-dose intravenous steroid (Methylprednisolone) intraoperatively would reduce neuroinflammation and enhance functional and radiological outcomes in decompressive surgeries for DCM. Primary objectives were to assess effect of intraoperative MP on modified Japanese Orthopedic Association (mJOA) score, Nurick grade, and MRI signal changes. Methods This prospective triple-blinded randomized controlled trial included 65 patients allocated into MP (n = 33) and control (n = 32) groups. MP (dose-1g) was administered intraoperatively at the beginning of decompression. Clinical outcome measures included mJOA score, Nurick grading, mJOA recovery rate (mJOA RR), Nurick recovery rate (NRR), and complication rates in both groups at 1-, 3-and 24-month follow-up. Radiological outcome was assessed by analyzing regression of T2W and T1W SI changes on MRI scans as per Chen’s grading at 24-months follow-up. Results MP group exhibited greater improvement in mJOA scores at 24-months (mean improvement: +6.69 vs +6.42; difference: +0.27, 95% CI: −0.37 to +0.91) but was statistically insignificant ( P = .107). Similarly, mJOA-RR showed a moderate effect size of 0.42 (95% CI: 0.04 to 0.80) and 0.37 (95% CI: −0.01 to 0.75) at 1-and 3-months follow-up respectively. NRR improvements were observed, with effect sizes of 0.40 (95% CI: 0.02 to 0.78) and 0.49 (95% CI: 0.11 to 0.87) at 1- and 3-months respectively, but not statistically significant ( P = .28). At 24-months, MP group had significantly better MRI outcome (Chen grading: mean change +1.15 vs +0.83; effect size: −0.71, 95% CI: −1.09 to −0.33; P = .038).Complication rates were comparable between both groups, emphasizing safety of MP administration. Conclusion Although null hypothesis was not proven, intraoperative MP administration in DCM surgery demonstrated safety and suggested potential neuroprotective benefits to enhance clinical recovery and reduce spinal cord signal changes. However, further large-scale, multicentric studies are needed to validate these findings and optimize its dose.
Overview of ICU Nurses’ Knowledge and Need Assessment for Instrument to Detect Sick Building Syndrome
Authors: Kurniawati Ninuk Dian , Dewi Yulis Setiya , Wahyuni Erna Dwi , Arifin Hidayat , Poddar Sandeep , AlFaruq Muhammad Fikri , Febriyanti Rofiqa Dwi 
Published: December 2024

Introduction Nurses in intensive care units (ICUs) are vulnerable to sick building syndrome (SBS), which can affect their health, performance, and patient safety. Understanding SBS is crucial in healthcare to protect both staff and patients. However, many ICU nurses lack knowledge about this condition and the necessary detection tools. Objectives This study aimed to describe ICU nurses’ knowledge about SBS and the need of an instrument to detect the signs and symptoms of SBS. Methods A cross-sectional study was conducted with a sample of 100 ICU nurses, recruited through simple random sampling from the Critical Care Indonesia Nurse Association. The study focused on nurses’ knowledge of SBS and the need for an instrument to detect it. Research instruments included basic respondent characteristics, nurses’ knowledge, and the need for an SBS detection tool. Data were analyzed using descriptive statistics. Results The majority of respondents exhibited a good level of knowledge (66%), yet many answered questions incorrectly regarding SBS etiology, symptoms, and effects. This was exemplified by incorrect responses attributing noise and chemicals as causes of SBS, overlooking fatigue as a symptom, and inaccurately assessing the physical effects of SBS. Notably, nurses demonstrated strong knowledge regarding SBS prevention (71%) and treatment (94%). Respondents unanimously supported the necessity of an instrument capable of detecting SBS among ICU nurses (71%), with an electronic instrument being the preferred option over other forms. Conclusion ICU nurses possess a good level of knowledge about SBS. It is recommended to develop and investigate an electronic-based instrument for detecting SBS. Additionally, implementing an e-learning educational program could further enhance the knowledge and management of SBS among healthcare professionals.
The Role of Pregnancy Intentions in U.S. Women's Contraceptive and Alcohol Use Behaviors
Authors: Shreffler Karina M. , Roland Alysa , Joachims Christine N. , Croff Julie M. 
Published: December 2024

Background Alcohol use in early pregnancy increases the risk for Fetal Alcohol Spectrum Disorders. Women who engage in heavy drinking and become pregnant when they are not actively trying to conceive are at heightened risk for alcohol-exposed pregnancies. Identifying factors associated with greater risk for alcohol-exposed pregnancies is critical for prevention. Objective This study explored the odds of contraceptive nonuse and heavy drinking for women trying to conceive or ambivalent about pregnancy as compared to those trying to avoid pregnancy. Methods Logistic regression analysis was used to examine the role of pregnancy intentions, including ambivalence, on contraceptive nonuse and heavy drinking among a national sample of 583 sexually active heterosexual women of childbearing age conducted online in 2024. Results Results showed that women who are trying to conceive or are ambivalent about pregnancy have higher odds of contraceptive nonuse than women trying to avoid pregnancy (OR = 13.19, p < .01 and OR = 3.56, p < .001, respectively), but no significant differences in heavy alcohol use by pregnancy intention. Conclusion Pregnancy intentions are associated with contraceptive nonuse but not heavy alcohol use. Delayed pregnancy recognition among those not actively trying to conceive but also not consistently using an effective form of contraception might place women who are avoiding or ambivalent about pregnancy at heightened risk for an alcohol-exposed pregnancy.