bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redeployment of Dental Core Trainees in the United Kingdom due to Coronavirus Disease 2019
Authors: Patel Misha , Menhadji Payvand , Mayor Serena 
Published: December 2020

Abstract
Objective The coronavirus disease 2019 (COVID-19) pandemic has affected professionals in all fields; none more so than medical and dental professionals. As dental core trainees (DCT) working in hospitals, we have been at the forefront of the crisis and one of the first in line for redeployment. Therefore, we decided to investigate the impact of COVID-19 on the redeployment of DCTs across the UK.
Materials and Methods  Data for this study was collected and shared between three project researchers. All researchers were undergoing dental core training in Oral Surgery and Restorative dentistry at Guy’s Hospital, London. An online survey was sent out via email and online social media platforms to reach as many DCTs as possible in the United Kingdom. Implied consent was obtained by respondents on submission of the survey.The survey consisted of five sections and was branched, with respondents answering different sections depending on their redeployment status. No qualitative data was collected, as all questions included in the survey were dichotomous or multiple-choice questions. The last two questions were in the form of a 5-point Likert scale, inviting respondents to rate five statements from strongly agree to strongly disagree.
Results A total of 150 participants responded, of which 34% had been redeployed due to the pandemic. The majority of DCTs were redeployed to an intensive care unit or similar setting, and over 75% of those redeployed were working with either COVID-19 positive/suspect patients. Additionally, 23.8% of respondents had stopped patient contact due to their medical status.
Conclusion Many DCTs have been deployed to departments outside of their specialty and expressed some anxiety as a result. Inevitably, this has resulted in disruption to their training program and education over the last few months. The response across the United Kingdom has been understandably variable due to the differing demands of the hospital trusts within which the DCTs work.
Role of Epidural Steroid Injection in Lumbar Spinal Stenosis—A Randomized Controlled Trial
Authors: Srivastava Mohit Kishore , Gupta Anil Kumar , Mishra Sudhir R. , Kumar Dileep , Ojha Bal Krishna , Yadav Ganesh 
Published: December 2020

Abstract
Background Degenerative lumbar spinal stenosis (DLSS) is an important cause of pain and disability among the elderly and common indication for spinal surgery. However, due to age-related comorbidities, it becomes difficult for elderly patients of DLSS to immediately go for operative treatment. Caudal epidural steroid injection (CESI) can be an effective procedure for a selected group of patients who have chronic function-limiting lower back and lower extremity pain secondary to DLSS. The aim of this study was to compare the effects of CESI with physical therapy in patients afflicted with DLSS.
Materials and Methods It is a single center, open-label randomized controlled trial conducted in department of Physical Medicine and Rehabilitation at a tertiary care center of northern India from January 2016 to August 2017 among DLSS patients. Trial was registered under the clinical trial registry of India. Patients were randomized in two groups–32 in intervention group A (CESI with local anesthetic and physical therapy) and 32 in control group B (physical therapy alone). Outcome measures were numerical pain rating scale (NPRS), Oswestry disability index (ODI), and mean claudication distance (MCD) at 3, 6, 12, and 24 weeks.
Results NPRS and ODI showed significant improvement at 3, 6, 12, and 24 weeks (group A >> group B). Improvement in MCD was seen at each follow-up from baseline (group A >> group B).
Conclusion Caudal epidural steroid administration can ameliorate pain, disability and claudication distance in DLSS patients, which provides them a window period for further definitive management.
Sinus Bradycardia after Extensive Neck Dissection and Total Thyroidectomy in a Pediatric Patient: A Case Report
Authors: Malli Antonia , Skondras Ioannis , Vakaki Maria , Passalides Alexander 
Published: December 2020

AbstractPostoperative complications after total thyroidectomy with extensive neck dissection in thyroid malignancies are well documented in the current literature. However, sinus bradycardia as a postthyroidectomy complication is a rare phenomenon and, to the best of our knowledge, few studies have identified it as a perioperative condition. In our study, we report a case of 9-year-old boy with papillary thyroid carcinoma, who underwent total thyroidectomy and bilateral neck dissection. Postoperatively, the surgery was complicated by initial vocal cord paresis and chyle leak. The patient also suffered from asymptomatic sinus bradycardia which self-resolved. Although causative factors cannot be determined by a single case, hypothyroidism, carotid sinus hypersensitivity, and bilateral damage to the middle cervical sympathetic ganglion could play a significant role in this uncommon pathophysiological condition.
A Single Layer Synthetic Dural Substitute Inlay is an Effective Sellar Reconstruction Technique in Endoscopic Transsphenoidal Pituitary Surgery
Authors: Chaskes Mark B. , Khoury Tawfiq , Chitguppi Chandala , Lavergne Pascal , Nyquist Gurston G. , Rabinowitz Mindy R. , Rosen Marc R. , Evans James J. 
Published: December 2020

Abstract
Objectives A variety of endonasal sellar repair techniques have been described; many are complex, multilayered, and carry potential morbidity. We propose an effective, technically simple single-layer repair for select sellar defects, including those with an intraoperative cerebrospinal fluid (CSF) leak. Our technique utilizes only a synthetic dural substitute inlay and dural sealant glue without packing or lumbar drainage.
Design This is a retrospective review-based study.
Setting This study was conducted at tertiary care center.
Participants Patients who underwent endoscopic transsphenoidal surgery for pituitary adenoma and sellar reconstruction with the aforementioned inlay technique. Patients were selected for this technique if they had an identified intraoperative CSF leak, a patulous diaphragm (expanded and thinned diaphragma sella), or a comorbidity excluding them from a simpler onlay only reconstruction.
Outcome Measures Postoperative CSF leak and sinonasal morbidity included in the study.
Results A total of 409 subjects were identified; 368 were initial resections. Gross total resection of the pituitary adenoma was achieved in 356 (87.0%) cases. Average tumor size was 2.6 ± 1.1 cm. Average tumor volume was 10.8 ± 12.1 cm3. There were 135 intraoperative CSF leaks and 196 patulous diaphragms. There were five postoperative CSF leaks (1.2%), all of which occurred in the first half of our series. Pre- and postoperative sino-nasal outcomes test-22 scores were 19.2 ± 18.2 and 18.8 ± 21.3 (p = 0.492), respectively.
Conclusion A synthetic dural substitute inlay and dural sealant glue is an excellent single-layer repair for sellar defects, even those with an intraoperative CSF leak. This technique is highly effective in preventing postoperative CSF leaks and does not utilize packing or lumbar drainage. It also avoids the potential cost and morbidity associated with more complex and multilayered closures.
Ethylene responses in non-climacteric horticultural crops
Authors: Ayub Ricardo Antonio , Pessenti Isabela Letícia , Pereira André Belmont 
Published: December 2020

Abstract

Ethylene regulates a number of metabolic

routes throughout the crop growing season at different environmental conditions. The most known process dealing with the action of such a hormone turns out to be ripening of climacteric fruits, which as opposed to non-climacteric fruits, reveals that ripening is accompanied by a respiration peak in conjunction with a concomitant outburst of ethylene production. Ethylene has been the target of scientific investigations carried out by researchers linked to fruit and horticulture sciences owing to physiological responsiveness of non-climacteric fruits regarding quality issues, since consumption has been plummeting whereas production costs soar more and more. Molecular techniques have been largely and globally scrutinized in order to provide a better understanding of ripening physiology of fruits and horticultural species. Physiological responses come to being enigmatic and quite complex because variability inherent to different horticultural species, maturation process per se, and cultivar factors impair the possibility of garnering knowledge in light of clear evidence on processes encrusted in ethylene production from non-climacteric fruits.
Identifying Naloxone Administrations in Electronic Health Record Data using a Text-Mining Tool
Authors: Derington Catherine G. , Mueller Shane R. , Glanz Jason M. , Binswanger Ingrid A. 
Published: December 2020

Background Effective and efficient methods are needed to identify naloxone administrations within electronic health record (EHR) data to conduct overdose surveillance and research. The objective of this study was to develop and validate a text-mining tool to identify naloxone administrations in EHR data. Methods Clinical notes stored in databases between January 2017 and March 2018 were used to iteratively develop a text-mining tool to identify naloxone administrations. The first iteration of the tool used broad search terms. Then, after reviewing clinical notes of overdose encounters, we developed a list of phrases that described naloxone administrations to inform iteration two. While validating iteration two, additional phrases were found, which were then added to inform the final iteration. The comparator was an administrative code query extracted from the EHR. Medical record review was used to identify true positives. The primary outcome was the positive predictive values (PPV) of the second iteration, final iteration, and administrative code query. Results Iteration two, the final iteration, and the administrative code had PPVs of 84.3% (95% confidence interval [CI] 78.6–89.0%), 83.8% (95% CI 78.6–88.2%), and 57.1% (95% CI 47.1–66.8%), respectively. Both iterations of the tool had a significantly higher PPV than the administrative code ( p < 0.001). Conclusions A text-mining tool improved the identification of naloxone administrations in EHR data from less than 60% with the administrative code to greater than 80% with both versions of the tool. Text-mining tools can inform the use of more sophisticated informatics methods, which often require significant time, resource, and expertise investment.
Predicting toxicity by quantum machine learning
Authors: Suzuki Teppei , Katouda Michio 
Published: December 2020

Abstract
In recent years, parameterized quantum circuits have been regarded as machine learning models within the framework of the hybrid quantum–classical approach. Quantum machine learning (QML) has been applied to binary classification problems and unsupervised learning. However, practical quantum application to nonlinear regression tasks has received considerably less attention. Here, we develop QML models designed for predicting the toxicity of 221 phenols on the basis of quantitative structure activity relationship. The results suggest that our data encoding enhanced by quantum entanglement provided more expressive power than the previous ones, implying that quantum correlation could be beneficial for the feature map representation of classical data. Our QML models performed significantly better than the multiple linear regression method. Furthermore, our simulations indicate that the QML models were comparable to those obtained using radial basis function networks, while improving the generalization performance. The present study implies that QML could be an alternative approach for nonlinear regression tasks such as cheminformatics.
An improved parasitic resistance extraction strategy alongside the effect of Cds at low gate bias voltages for AlGaN/GaN HEMTs
Authors: Kaushik Pragyey Kumar , Singh Sankalp Kumar , Gupta Ankur , Basu Ananjan 
Published: December 2020

Abstract
An improved parasitic resistance extraction from small-signal equivalent-circuit and effect of C

ds
in GaN HEMTs is presented. Parasitic capacitances are evaluated at ‘cold pinch off’ condition. More accurate extraction method of parasitic resistance is presented at low gate bias voltages compared to earlier published work. The impact of drain to source capacitance (C

ds
) at low gate bias voltage is also reported in this manuscript. The validity of proposed parasitic resistance extraction procedure and effect of drain to source capacitance (C

ds
) has been verified through error analysis with the measured S-parameters data of 0.8-μm of AlGaN/GaN high electron mobility transistor consisting 2 × 200-μm gate width. Proposed method shows good harmony between simulated and measured data up to 40 GHz frequency.
PROSS 2: a new server for the design of stable and highly expressed protein variants
Authors: Weinstein Jonathan Jacob , Goldenzweig Adi , Hoch ShlomoYakir , Fleishman Sarel Jacob 
Published: December 2020

ABSTRACT

Summary
Many natural and designed proteins are only marginally stable limiting their usefulness in research and applications. Recently, we described an automated structure and sequence-based design method, called PROSS, for optimizing protein stability and heterologous expression levels that has since been validated on dozens of proteins. Here, we introduce improvements to the method, workflow and presentation, including more accurate sequence analysis, error handling and automated analysis of the quality of the sequence alignment that is used in design calculations.

Availability and implementation
PROSS2 is freely available for academic use at https://pross.weizmann.ac.il.
Cryptic genetic diversity and cytonuclear discordance characterize contact among Canada jay (Perisoreus canadensis) morphotypes in western North America
Authors: Graham Brendan A , Cicero Carla , Strickland Dan , Woods John G , Coneybeare Howard , Dohms Kimberly M , Szabo Ildiko , Burg Theresa M 
Published: December 2020

AbstractThree distinct Canada jay (Perisoreus canadensis) morphotypes with easily recognizable plumage traits come into contact in western North America. Recent work demonstrated high genetic structure across the species’ range; however, patterns of genetic variation in these contact zones remain unknown. We categorized 605 individuals into one of three morphotypes (Pacific, Rocky Mountain, and Boreal) based on plumage, and genotyped individuals at the mtDNA control region and 12 microsatellite loci to assess the extent of hybridization between morphotypes. Our data showed cryptic genetic diversity and high cytonuclear discordance among morphotypes within contact zones, which is likely the result of recent and historical admixture. The distributions of the Boreal and Pacific morphotypes each showed a strong association with a single, distinct genetic group, whereas the Rocky Mountain morphotype exhibited higher genetic diversity and was associated with multiple genotypes. Our analyses show the importance of considering both plumage and genetic traits when examining contact zones between closely related taxa. Finally the data presented in this study reaffirm that the Pacific morphotype is distinct from the Boreal and Rocky Mountain morphotypes based on genetic, phenotypic and ecological data, indicating that the Pacific morphotype should be re-elevated to a full species.
Trabecular complexity as an early marker of cardiac involvement in Fabry disease
Authors: Camporeale Antonia , Moroni Francesco , Lazzeroni Davide , Garibaldi Silvia , Pieroni Maurizio , Pieruzzi Federico , Lusardi Paola , Spada Marco , Mignani Renzo , Burlina Alessandro , Carubbi Francesca , Econimo Laura , Battaglia Yuri , Graziani Francesca , Pica Silvia , Chow Kelvin , Camici Paolo G , Lombardi Massimo 
Published: December 2020

Abstract

Aims
Fabry cardiomyopathy is characterized by glycosphingolipid storage and increased myocardial trabeculation has also been demonstrated. This study aimed to explore by cardiac magnetic resonance whether myocardial trabecular complexity, quantified by endocardial border fractal analysis, tracks phenotype evolution in Fabry cardiomyopathy.

Methods and results
Study population included 20 healthy controls (12 males, age 32±9) and 45 Fabry patients divided into three groups: 15 left ventricular hypertrophy (LVH)-negative patients with normal T1 (5 males, age 28±13; Group 1); 15 LVH-negative patients with low T1 (9 males, age 33±9.6; Group 2); 15 LVH-positive patients (11 males, age 53.5±9.6; Group 3). Trabecular fractal dimensions (Dfs) (total, basal, mid-ventricular, and apical) were evaluated on cine images. Total Df was higher in all Fabry groups compared to controls, gradually increasing from controls to Group 3 (1.27±0.02 controls vs. 1.29±0.02 Group 1 vs. 1.30±0.02 Group 2 vs. 1.34±0.02 Group 3; P&lt;0.001). Group 3 showed significantly higher values of all Dfs compared to the other Groups. Both basal and total Dfs were significantly higher in Group 1 compared with controls (basal: 1.30±0.03 vs. 1.26±0.04, P =0.010; total: 1.29±0.02 vs. 1.27±0.02, P=0.044). Total Df showed significant correlations with: (i) T1 value (r=−0.569; P&lt;0.001); (ii) LV mass (r=0.664, P&lt;0.001); (iii) trabecular mass (r=0.676; P &lt;0.001); (iv) Mainz Severity Score Index (r=0.638; P&lt;0.001).

Conclusion
Fabry cardiomyopathy is characterized by a progressive increase in Df of endocardial trabeculae together with shortening of T1 values. Myocardial trabeculation is increased before the presence of detectable sphingolipid storage, thus representing an early sign of cardiac involvement.
Incidental detection of myocardial clefts in a patient with acute inferior ST-segment elevation myocardial infarction: a very unusual and potentially ominous association—a case-report
Authors: Garau Giovanni , Bataille Yoann , Larose Eric , Hoffer Etienne 
Published: December 2020

Abstract

Background
The crescent availability of high-resolution cardiac imaging allows detection of myocardial structural variations. Differentiate these entities from others with different clinical significance can be challenging. Clinicians should be familiar with myocardial clefts to avoid erroneous diagnosis.

Case summary
A 63-year-old smoker man alerted the emergency medical system for sudden chest pain. The electrocardiogram showed Pardee wave in inferior leads. Coronary angiography evidenced a 100% occlusion of right coronary artery that was treated by angioplasty and drug-eluting stent implantation with optimal angiographic result. At ventriculography, two fissure-like protrusion were observed in the inferior wall. Urgent transthoracic echocardiogram (TTE) demonstrated two deep fissures on the mid-inferior wall, contained by a thin sub-epicardial layer, with sub-total obliteration during systole. A diagnosis of myocardial clefts was suspected and after Heart Team discussion, a conservative strategy was proposed. Early cardiac magnetic resonance (CMR) confirmed two myocardial crypts on the mid-inferior wall. Stability of myocardial fissures and absence of left ventricular remodelling was confirmed by TTE, in a 2 years of follow-up period.

Discussion
Myocardial cleft should always be considered in the differential diagnosis of myocardial wall defects. In a patient presenting with an acute myocardial infarction, the main differential diagnosis is pseudoaneurysm. In this setting modified TTE views and meticulous analysis of CMR sequences are recommended to confirm the diagnosis and estimate the risk of myocardial rupture.
Investigating the culturable atmospheric fungal and bacterial microbiome in West Texas: implication of dust storms and origins of the air parcels
Authors: Elmassry Moamen M , Ray Nandini , Sorge Sara , Webster Jennifer , Merry Kyle , Caserio Angelica , Vecellio Daniel J , Kruczek Cassandra , Dowd Scot , Ardon-Dryer Karin , Vanos Jennifer , San Francisco Michael J 
Published: December 2020

ABSTRACTIndividuals often experience ailments such as allergies, asthma and respiratory tract infections throughout the year. Weather reports often include estimations of common allergens that can affect these individuals. To describe the local ‘atmospheric microbiome’ in Lubbock, Texas, USA, we examined the culturable fungal and bacterial microbiome present in the air on calm and dust storm days using internal transcribed spacer (ITS)-1 and 16S rRNA amplicon sequencing, respectively. While some types of airborne fungi were frequently present throughout the year, distinct differences were also observed between calm and dust storm days. We also observed the influence of the origin of air parcels and wind elevation of the air trajectory. The most abundant genera of fungi identified during the study period were Cryptococcus, Aureobasidium, Alternaria, Cladosporium and Filobasidium. This observation was not surprising considering the agricultural intensive environment of West Texas. Interestingly, Cladosporium, a common allergenic mold, was increased during days with dust storm events. The predominant bacterial genera observed were Bacillus, Pseudomonas, Psychrobacter, Massilia and Exiguobacterium. The relative abundance of the psychrophiles, Psychrobacter and Exiguobacterium, was surprising, given the semi-aridity of West Texas. Coupling our observations with back trajectories of the wind (Hybrid Single-Particle Lagrangian Integrated Trajectory models) demonstrated that dust storms, regional anthropogenic activity and origin of air parcels are important influences on the diversity and temporal presence of the atmospheric microbiome.
Comparison of the two up-to-date sequencing technologies for genome assembly: HiFi reads of Pacific Biosciences Sequel II system and ultralong reads of Oxford Nanopore
Authors: Lang Dandan , Zhang Shilai , Ren Pingping , Liang Fan , Sun Zongyi , Meng Guanliang , Tan Yuntao , Li Xiaokang , Lai Qihua , Han Lingling , Wang Depeng , Hu Fengyi , Wang Wen , Liu Shanlin 
Published: December 2020

Abstract

Background
The availability of reference genomes has revolutionized the study of biology. Multiple competing technologies have been developed to improve the quality and robustness of genome assemblies during the past decade. The 2 widely used long-read sequencing providers—Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT)—have recently updated their platforms: PacBio enables high-throughput HiFi reads with base-level resolution of &gt;99%, and ONT generated reads as long as 2 Mb. We applied the 2 up-to-date platforms to a single rice individual and then compared the 2 assemblies to investigate the advantages and limitations of each.

Results
The results showed that ONT ultralong reads delivered higher contiguity, producing a total of 18 contigs of which 10 were assembled into a single chromosome compared to 394 contigs and 3 chromosome-level contigs for the PacBio assembly. The ONT ultralong reads also prevented assembly errors caused by long repetitive regions, for which we observed a total of 44 genes of false redundancies and 10 genes of false losses in the PacBio assembly, leading to over- or underestimation of the gene families in those long repetitive regions. We also noted that the PacBio HiFi reads generated assemblies with considerably fewer errors at the level of single nucleotides and small insertions and deletions than those of the ONT assembly, which generated an average 1.06 errors per kb and finally engendered 1,475 incorrect gene annotations via altered or truncated protein predictions.

Conclusions
It shows that both PacBio HiFi reads and ONT ultralong reads had their own merits. Further genome reference constructions could leverage both techniques to lessen the impact of assembly errors and subsequent annotation mistakes rooted in each.