bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of adverse pregnancy outcomes of late‐ and postterm pregnancies in advanced maternal age: A national cohort study
Authors: Kortekaas Joep C. , Kazemier Brenda M. , Keulen Judit K. J. , Bruinsma Aafke , Mol Ben W. , Vandenbussche Frank , Van Dillen Jeroen , De Miranda Esteriek 
Published: February 2020

AbstractIntroductionThere is an increase in women delivering ≥35 years of age. We analyzed the association between advanced maternal age and pregnancy outcomes in late‐ and postterm pregnancies.Material and methodsA national cohort study was performed on obstetrical low‐risk women using data from the Netherlands Perinatal Registry from 1999 to 2010. We included women ≥18 years of age with a singleton pregnancy at term. Women with a pregnancy complicated by congenital anomalies, hypertensive disorders or diabetes mellitus were excluded. Composite adverse perinatal outcome was defined as stillbirth, neonatal death, meconium aspiration syndrome, 5‐minute Apgar score <7, neonatal intensive care unit admittance and sepsis. Composite adverse maternal outcome was defined as maternal death, placental abruption and postpartum hemorrhage of >1000 mL.ResultsWe stratified the women into three age groups: 18‐34 (n = 1 321 366 [reference]); 35‐39 (n = 286 717) and ≥40 (n = 40 909). Composite adverse perinatal outcome occurred in 1.6% in women aged 18‐34, 1.7% in women aged 35‐39 (relative risk [RR] 1.06, 95% confidence interval [95% CI] 1.03‐1.08) and 2.2% in women aged ≥40 (RR 1.38, 95% CI 1.29‐1.47), with 5‐minute Apgar score <7 as the factor contributing most to the outcome. Composite adverse maternal outcome occurred in 4.6% in women aged 18‐34, 5.0% in women aged 35‐39 (RR 1.08, 95% CI 1.06‐1.10) and 5.2% in women aged ≥40 (RR 1.14, 95% CI 1.09‐1.19), with postpartum hemorrhage >1000 mL as the factor contributing most to the outcome. In all age categories, the risk of adverse pregnancy outcomes was higher for nulliparous than for multiparous women. The risk of adverse outcomes increased in both nulliparous and parous women with advancing gestational age. When adjusted for parity, onset of labor and gestational age, advanced maternal age is associated with an increase in both composite adverse perinatal and maternal outcomes.ConclusionsThe risk of adverse pregnancy outcome increases with advancing maternal age. Women aged ≥40 have an increased risk of adverse perinatal and maternal outcome when pregnancy goes beyond 41 weeks.
Risk of molecular recurrence after tyrosine kinase inhibitor discontinuation in chronic myeloid leukaemia patients: a systematic review of literature with a meta‐analysis of studies over the last ten years
Authors: Dulucq Stéphanie , Astrugue Cyril , Etienne Gabriel , Mahon François‐Xavier , Benard Antoine 
Published: February 2020

SummaryMore than 10 years ago, the first pilot observational study of imatinib discontinuation was reported in chronic myeloid leukaemia (CML) patients in deep molecular response (DMR). Several studies have been published since then, in patients treated with frontline imatinib, or second‐generation tyrosine kinase inhibitors (TKI) in first or second line but also on second attempt of TKI discontinuation. Our objective was to estimate, through meta‐analyses of the literature data, the probability of molecular recurrence (MolRec) in the time periods of 0–6, 6–12, 12–18 and 18–24 months after a first and second TKI discontinuation and the probability of re‐acquisition of DMR after MolRec. The Medline and Scopus databases were searched up to April 2019. The studies were selected by three independent reviewers. Random‐effect meta‐analyses were conducted using the MetaXL software. The probability of MolRec in the time periods 0–6, 6–12, 12–18 and 18–24 months after the first attempt was respectively 35%, 8%, 3% and 3%, whereas the probability of MolRec in the time periods 0‐6, 6‐12 and 12‐18 after the second attempt was 48%, 27% and 12% respectively. Re‐acquisition of a DMR was observed in 90% of patients. Most of the MolRec occur during the first six months in case of a first attempt, whereas the second MolRec occurs over a larger window of time.
Satisfaction with life and depressive symptoms in living organ donors and non‐donors: New insights from the National Living Donor Assistance Center
Authors: Mathur Amit K. , Hong Barry A. , Goodrich Nathan P. , Xing Jiawei , Warren Patricia H. , Gifford Kimberly A. , Merion Robert M. , Ojo Akinlolu O. 
Published: February 2020

AbstractBackgroundPrevious studies indicate there may be psychological consequences of being unable to serve as a living donor, but these have not been explored in a large national cohort of low‐income individuals who initiated living donor evaluation in US transplant centers.MethodsUsing data from 6574 National Living Donor Assistance Center (NLDAC) participants (November 1, 2007‐December 31, 2018), we utilized a cross‐sectional study design to evaluate short‐term depressive symptoms and satisfaction with life in living donors and non‐donors (those who were declined or withdrew from evaluation) using the Satisfaction with Life Scale (SWLS) and the PHQ‐8, with and without risk adjustment using linear regression.ResultsNational Living Donor Assistance Center participants originated from 207 US transplant centers. 52% of NLDAC participants responded to the survey (n = 3423; donors = 2848 (58.6% of all donors), non‐donors = 575 (33.5% of all non‐donors); ncenters = 201)). Respondents were significantly older, more likely to be female, white, non‐Hispanic, married, more educated, more full‐time employed, and more likely to be unrelated to the recipient vs non‐respondents (all, P < .001). Among survey respondents, donors were significantly younger, more likely to be non‐Hispanic, employed, and related to the recipient compared to non‐donors (all, P < .05). Higher PHQ‐8 scores were correlated with lower SWL scores (r = −.32, P < .001). Both groups displayed high SWLS (donors vs non‐donors: 27.1 vs 26.3, P = .002). Both groups had low levels of depressive symptoms overall, but donors had more symptoms than non‐donors (3.5 vs 2.4, P < .001). After risk adjustment, non‐donors had significantly less depressive symptoms by PHQ‐8 (28% lower, P < .001), but had lower life satisfaction (1.2 points lower, P < .001).ConclusionsDonors and non‐donors have high global levels of overall life satisfaction and low levels of depressive symptoms at 8 weeks after donation or denial. While small effect sizes were observed between groups in these outcomes, being a non‐donor was an independent risk factor for lower life satisfaction, which warrants further evaluation.
The ‘Populist’ Right Challenge to Neoliberalism: Social Policy between a Rock and a Hard Place
Authors: Putzel James 
Published: February 2020

ABSTRACTThis article looks at the rise of right populist politics in both developed and developing countries, and its implications for social policy. The author locates the cause for the right populist surge in the legacies of neoliberalism, paying particular attention to the way neoliberal reforms have affected popular attitudes towards politics. The commodification of politics and social services has stoked mass cynicism towards reigning neoliberal elites, creating receptive audiences for populist slogans to ‘drain the swamp’ at the heart of governments. More controversially, the author argues that popular resentments toward neoliberal social policies based on the recognition of the rights of women, minorities, migrants and the poor have made communities susceptible to the racist and misogynist messages of the right populists. Through case studies looking at the United States, Brazil and the Philippines the author argues that the biggest impact of right populists on social policies can be found in their discourses and authoritarian practices of social exclusion.
Cover Image, Volume 22, Issue 3
Authors: Toth Peter P. , Fazio Sergio , Wong Nathan D. , Hull Michael , Nichols Gregory A. 
Published: February 2020

The outside front cover image is based on the Review Article Risk of Cardiovascular Events in Patients with Hypertriglyceridemia: A Review of Real‐World Evidence by Peter Paul Toth, NATHAN D. WONG, GREGORY, A. NICHOLS et al., https://doi.org/10.1111/dom.13921.
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Cover Image, Volume 22, Issue 3
Authors: Matza Louis S. , Boye Kristina S. , Stewart Katie D. , Coyne Karin S. , Wullenweber Paula K. , Cutts Katelyn N. , Jordan Jessica B. , Wang Qianqian , Yu Maria , Currie Brooke M. , Malley Karen G. , Ishak K. Jack , Hietpas Ryan T. , García‐Pérez Luis‐Emilio 
Published: February 2020

The outside back cover image is based on the Original Article Crossover Clinical Trial Assessing Patient PREFERence between the Dulaglutide Pen and the Semaglutide Pen (PREFER) by Louis S. Matza, Katie Stewart, KARIN S. COYNE et al., https://doi.org/10.1111/dom.13902.
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Efficacy and safety of insulin glargine/lixisenatide fixed‐ratio combination (iGlarLixi) in Japanese patients with type 2 diabetes mellitus inadequately controlled on basal insulin and oral antidiabetic drugs: The LixiLan JP‐L randomized clinical trial
Authors: Kaneto Hideaki , Takami Akane , Spranger Robert , Amano Atsushi , Watanabe Daisuke , Niemoeller Elisabeth 
Published: February 2020

AbstractAimsTo assess efficacy and safety of fixed‐ratio (1:1) combination insulin glargine and lixisenatide (iGlarLixi) compared to insulin glargine U100 (iGlar), with metformin, in Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on basal insulin and oral antidiabetic drugs (OADs).Materials and methodsThis 26‐week, randomized, open‐label study compared iGlarLixi to iGlar, both with metformin in adult Japanese patients with T2DM and hemoglobin (Hb) A1c ≥7.5% to ≤9.5%, treated with basal insulin and 1 or 2 OADs. Five hundred and twelve patients were randomized after a 12‐week run‐in, when iGlar was introduced and/or further titrated and OADs other than metformin were stopped. The primary endpoint was change in HbA1c from baseline to week 26.ResultsiGlarLixi (n = 255) demonstrated significantly greater reductions in HbA1c (−1.27%) than iGlar (n = 257, −0.53%) (LS mean difference: –0.74%, P < .0001) at week 26, confirming the superiority of iGlarLixi. Significantly, more iGlarLixi patients reached target HbA1c <7% at week 26 (51.8% vs 16.0% for iGlar). iGlarLixi patients lost weight in contrast to iGlar patients (−0.51 kg vs +0.55 kg). Documented symptomatic hypoglycemia (plasma glucose ≤ 3.9 mmol/L) was observed in 18.8% of iGlarLixi patients vs 16.7% of iGlar patients. iGlarLixi patients had more gastrointestinal‐related adverse events than iGlar patients (33.3% vs 8.6%), primarily nausea (16.9% vs 0.8%). However, the treatment was generally well‐tolerated.ConclusionsA once‐daily injection of iGlarLixi with metformin is an effective, well‐tolerated, and simple therapeutic intervention providing significant improvement in glycemic control in Japanese patients with T2DM inadequately controlled on basal insulin and up to two OADs.Clinical Trial Number: NCT02752412.
Heliovaccination: Solar mediated immunity against cancer
Authors: Uzoigwe Chika Edward 
Published: February 2020

AbstractThe protective effect of ultraviolet (UV) light against a host of malignancies is well characterised. It was recognised by WHO in their 2006 publication on the global burden of UV‐mediated disease. The mechanism by which this oncoprotective effect occurs remains unclear. Vitamin D has been mooted as a potential mediator. However, the evidence does not support this. I suggest that UV irradiation of the skin produces nascent malignant and premalignant cells with associated generic tumor‐specific antigens. These are eliminated by immunosurveillance resulting in adaptive immunity. The clonal expansion of these immune cells protects against tumors in other viscera, effectively immunising the host. The evidence for this “heliovaccination” is very strong. Childhood UV exposure protects against cancer in adulthood. Tumor naïve individuals possess anti‐tumor antibodies. Antigen‐presenting cells mobilise to the skin following specifically UVB skin irradiation. It is time to rethink the link between UV light and cancer.
The neoliberal logic of state seals of biliteracy
Authors: Schwedhelm Maria C. , King Kendall A. 
Published: February 2020

AbstractState‐issued seals and certificates of biliteracy are increasingly common nationwide. Nevertheless, limited research to date has examined how this state legislation functions as language in education policy and the ideological foundations of these policies. Addressing this gap, the present paper examines state seals as an instance of neoliberal language education policy and addresses how the policy has been constructed in public discourse and interview narratives and how it has been implemented to date. Focusing on one state, Minnesota, we demonstrate the neoliberal logic that undergirds state seals of biliteracy. Data revealed uneven availability of assessments and access to seals across the state. Access was largely determined by market‐oriented, rational choice ideologies, and dependent upon the language and district in question. Analysis also suggested that while Minnesota seals have been constructed in public discourse as a financial asset, their value is unclear in a potentially inflated marketplace of academic credentials within the state.
Credentialing heritage: The role of community heritage language schools in implementing the Seal of Biliteracy
Authors: Borowczyk Margaret 
Published: February 2020

AbstractThe introduction of the Seal of Biliteracy (SoBL) has presented a potent opportunity for community heritage language schools to credential the heritage language proficiency of their students in a U.S. context. This study explores the involvement of community heritage language schools in the SoBL initiative. It investigates how seven heritage language school administrators view the SoBL, what they see as its potential benefits, and what barriers they see to its full implementation. Results show that despite many potential benefits for community‐based schools, factors such as the status of the language in the wider community, a lack of articulation with local high schools, uneven parental power, and a lack of appropriate assessments, present barriers to full implementation. The paper concludes with suggestions for how to address these barriers and hopes to provide a roadmap for future collaboration between SoBL administrators and heritage language schools.
Woody plant encroachment intensifies under climate change across tundra and savanna biomes
Authors: García Criado Mariana , Myers‐Smith Isla H. , Bjorkman Anne D. , Lehmann Caroline E. R. , Stevens Nicola 
Published: February 2020

AbstractAimBiomes worldwide are shifting with global change. Biomes whose extents are limited by temperature or precipitation, such as the tundra and savanna, may be particularly strongly affected by climate change. While woody plant encroachment is prevalent across both biomes, its relationship to temperature and precipitation change remains unknown. Here, we quantify the degree to which woody encroachment is related to climate change and identify its main associated drivers.LocationTundra and savanna biomes.Time period1992 ± 20.27–2010 ± 5.62 (mean ± SD). 1876–2016 (range).Major taxa studiedWoody plants (shrubs and trees).MethodsWe compiled a dataset comprising 1,089 records from 899 sites of woody plant cover over time and attributed drivers of woody cover change across these two biomes. We calculated cover change in each biome and assessed the degree to which cover change corresponds to concurrent temperature and precipitation changes using multiple climate metrics. Finally, we conducted a quantitative literature review of the relative importance of attributed drivers of woody cover change.ResultsWoody encroachment was widespread geographically and across climate gradients. Rates of woody cover change (positive or negative) were 1.8 times lower in the tundra than in the savanna (1.8 vs. 3.2%), while rates of woody cover increase (i.e., encroachment) were c. 1.7 times lower in the tundra compared with the savanna (3.7 vs. 6.3% per decade). In the tundra, magnitudes of woody cover change did not correspond to climate, while in the savanna, greater cover change corresponded with increases in precipitation. We found higher rates of woody cover change in wetter versus drier sites with warming in the tundra biome, and higher rates of woody cover change in drier versus wetter sites with increasing precipitation in the savanna. However, faster rates of woody cover change were not associated with more rapid rates of climate change across sites, except for maximum precipitation in the savanna.Main conclusionsWoody encroachment was positively related to warming in the tundra and increased rainfall in the savanna. However, cover change rates were not predicted by rates of climate change, which can be partially explained by climate interactions in both biomes. Additional likely influences include site‐level factors, time‐lags, plant‐specific responses, and land use and other non‐climate drivers. Our findings highlight the complex nature of climate change impacts in biomes limited by seasonality, which should be accounted for to realistically estimate future responses across open biomes under global change scenarios.
Effects of Pediococcus pentosaceus on fermentation, aerobic stability and microbial communities during ensiling and aerobic spoilage of total mixed ration silage containing alfalfa (Medicago sativa L.)
Authors: Jiang Di , Li Bingnan , Zheng Mingli , Niu Dongze , Zuo Sasa , Xu Chuncheng 
Published: February 2020

AbstractThe objective of this study was to evaluate the effect of Pediococcus pentosaceus inoculation on the fermentation quality and the dynamics of microbial communities during ensiling and aerobic exposure in total mixed ration (TMR) silage. The TMR were prepared using alfalfa (Medicago sativa L.), maize meal, soybean curd residue, soybean meal, calcium carbonate, vitamin‐mineral supplement and salt (60.0:21.4:15.0:2.0:1.0:0.5:0.1, dry matter basis) with or without P. pentosaceus inoculation (105 cfu/g fresh matter) followed by 14 or 28 days of ensiling and exposed to air. Microbial communities were detected by high‐throughput sequencing. After ensiling, P. pentosaceus inoculation benefited silage fermentation as indicated by increased lactic acid content and decreased pH, whereas had no effect on aerobic stability. Taxonomic bacterial community was dominated by Lactobacillales after ensiling, with a notable increase in spoilage microorganisms as a result of aerobic exposure. Aerobically exposed TMR was characterized by an increase of operational taxonomic units belonging to the Hypocreales and with yeast genus Cryptococcus, whereas Monascus was the major mold genus in the aerobically exposed silages. Candida was detected with higher relative abundance only in 28 days aerobically exposed sample inoculated with P. pentosaceus. P. pentosaceus inoculation has good effects on improving the fermentation quality and shows a potential to inhibit the proliferation of Monascus at 28 days of ensiling.
The views and experiences of patients and health‐care professionals on the disclosure of adverse events: A systematic review and qualitative meta‐ethnographic synthesis
Authors: Sattar Raabia , Johnson Judith , Lawton Rebecca 
Published: February 2020

AbstractObjectiveTo synthesize the literature on the views and experiences of patients/family members and health‐care professionals (HCPs) on the disclosure of adverse events.MethodsSystematic review of qualitative studies. Searches were conducted in MEDLINE, Embase, PubMed, CINAHL and PsycINFO. Study quality was evaluated using the Critical Appraisal Skills Programme tool. Qualitative data were analysed using a meta‐ethnographic approach, comprising reciprocal syntheses of ‘patient’ and ‘health‐care professional’ studies, combined to form a lines‐of‐argument synthesis embodying both perspectives.ResultsFifteen studies were included in the final syntheses. The results highlighted that there is a difference in attitudes and expectations between patients and HCPs regarding the disclosure conversation. Patients/family members expressed a need for information, the importance of sincere regret and a promise of improvement. However, HCPs faced several barriers, which hindered appropriate disclosure practices. These included difficulty of disclosure in a blame culture, avoidance of litigation, lack of skills on how to conduct disclosure and inconsistent guidance. A lines‐of‐argument synthesis is presented that identified both the key elements of an ideal disclosure desired by patients and the facilitators for HCPs, which can increase the likelihood of this taking place.ConclusionsAlthough patients/family members and HCPs both advocate disclosure, several barriers prevent HCPs from conducting disclosure effectively. Both groups have different needs for disclosure. To meet patients’ requirements, training on disclosure for HCPs and the development of an open, transparent culture within organizations are potential areas for intervention.
A randomized controlled trial examining an exam room poster to prompt communication about weight
Authors: Brown Callie L. , Howard Janna B. , Perrin Eliana M. 
Published: February 2020

SummaryBackgroundRecognition of childhood weight status is important to the adoption of healthy lifestyle behaviours.ObjectivesWe assessed whether an exam room educational poster addressing weight and healthy lifestyle behaviours was acceptable to parents, prompted parent‐provider communication or improved parental weight perception accuracy.MethodsIn this multi‐site randomized controlled trial, exam rooms were randomized to display the posters (English and Spanish) or not. Children ages 3 to 8 years (N = 965) attending well visits were weighed and roomed per usual clinic protocol. After the visit, parents completed a questionnaire assessing demographics, child weight status perceptions and whether they discussed weight status with provider or were shown growth charts. We used separate logistic regression analyses to examine associations between intervention status and: asking provider about child weight, being shown growth charts, and accuracy of weight perception, adjusting for covariates and clustering by exam room.ResultsOf the parents who saw the poster, 97% liked seeing it and reported greater understanding of weight status visualization (96%) and healthy lifestyle behaviours (94%). Parents who saw the poster were more likely to report being shown a growth chart (OR 1.87, 95% 1.06, 3.30) but were not more likely to ask about their child's weight status nor accurately report their child's weight status.ConclusionsAn educational exam room poster about healthy weight was well‐received by parents and prompted providers to show the child's growth chart but did not prompt parent‐initiated conversations about weight status nor improve parental weight perception accuracy.
Awl‐like HfC nanowires grown on carbon cloth via Fe‐catalyzed in a polymer pyrolysis route
Authors: Fu Yanqin , Zhang Yulei , Yin Xuemin , Li Tao , Zhang Jian 
Published: February 2020

AbstractAwl‐like hafnium carbide (HfC) nanowires were successfully synthesized on carbon cloth in a polymer pyrolysis route via Fe‐catalyzed for the first time. A detailed study of the HfC nanowire morphology was performed. X‐ray diffraction, scanning electron microscopy and transmission electron microscopy were used to investigate the morphology and microstructure of the obtained awl‐like HfC nanowires and the growth mechanism was also discussed in detail. Results show that HfC nanowires wrapped by amorphous HfO2 layer with ~10 nm in thickness display awl‐like structure and the nanowire's surface exhibit prismatic geometry. The diameter of the nanowire decreases from the bottom (~500 nm) to the top (~100 nm). The growth mechanism of the awl‐like HfC nanowires was mainly affected by the combination of bottom‐type vapor‐liquid‐solid (VLS) and solid‐liquid‐solid.