bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibin B in stromal-cell ovarian tumors
Authors: Lyubimova N. V. , Beishembaev A. M. , Timofeev Yu. S. , Kushlinskii N. E. 
Published: March 2020

Background. Tumors of stroma of the sex cord include a family of tumors that are diverse in structure and biological characteristics, including hormone-active ovarian tumors, such as granulosa cell tumor (GCT) of the ovary and a tumor from Sertoli–Leydig cells. For these types of tumors, of particular importance is the analysis of biochemical markers, among which the most promising is inhibin B.The objective of the study. Comparative analysis of inhibin B levels in the blood serum of patients with stromal cell tumors and other types malignancies.Materials and methods. 64 patients with primary ovarian tumors were examined: 31 – GCT of the ovary, 16 – tumors from Sertoli–Leydig cells, 17 – adenocarcinomas. Comparison group – 20 patients with malignant tumors of other localizations, control – 74 healthy women and 37 patients with benign ovarian tumors. Inhibin B was determined in blood serum using the standardized Inhibin B Gen II ELISA (Beckman Coulter, USA) immunoassay.Results. The analysis of inhibin B levels in last days of the luteal phase, show an increase of marker level in patients with GCT and tumors from Sertoli–Leydig cells, while in ovarian adenocarcinomas and malignant tumors of other locations inhibin B secretion doesn’t differ from the control. The sensitivity of inhibin B in diagnostics of GCT was 93.5 %, in tumor from Sertoli–Leydig cells – 81.3 % with specificity – 100 %.Conclusion. Inhibin B is an effective biomarker of GCT and ovarian tumors from Sertoli–Leydig cells, which results must be interpreted according the functional state of the ovaries.
Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma
Authors: Khakimova G. G. , Zabotina T. N. , Tryakin A. A. , Borunova A. A. , Davidova T. V. , Kalinin A. E. , Vakhabova Yu. V. , Zakharova E. N. , Tabakov D. V. 
Published: March 2020

Objective: to study the state of cellular immunity in patients with gastric adenocarcinoma.Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical / combined treatment or independent chemotherapy, respectively, at the N. N. Blokhin National Medical ResearchCenter of Oncology. Peripheral blood sampling was carried out before starting treatment. We studied the cellular composition of peripheral blood, as well as systemic immunity parameters determined by flow cytometry (CD3+CD4+; CD3+CD8+; CD4+CD8+; CD4+/CD8+; CD3–CD16+CD56+; CD3–CD19+), and their prognostic significance in relation to overall survival and progression-free survival.Results. The prognostic value of the relative indicator of platelet lymphocytic index was determined: progression-free survival in patients with a high level of platelet-lymphocytic index (>208.7) was higher: 8.1 months versus 4.5 months (p = 0.0027). A favorable prognosis for overall survival was an increase in the number of CD3–CD19+ lymphocytes (hazard ratio (HR) 0.91; 95 % confidence interval (CI) 0.85–0.97; p = 0.007), and an unfavorable prognosis was an increase in the number of neutrophils (HR 1.26; 95 % CI 1.05–1.50; p = 0.012), platelet count (HR 1.01; 95 % CI 1.0–1.01; p = 0.043), as well as an increase in the number of NK cells (HR 1.04, 95 % CI 1.0–1.09; p = 0.029).Conclusion. Indicators of the cellular composition of peripheral blood, characterizing a systemic inflammatory reaction, as well as indicators of systemic immunity, can serve as additional prognostic factors for gastric cancer.
Functional Aspect of a Protocol on Administrative Offense as a Jurisdictional Act
Authors: Tymoshenko I. V. 
Published: March 2020

In June 2019, the official website of the Government of the Russian Federation published the Concept of the New Code of Administrative Offences, the enactment of which is planned for 1 January 2021. This Concept indicates that the factors that reduce the effectiveness of the existing Administrative Code of the Russian Federation include, among other things, problems in law enforcement at the stages of initiation and consideration of cases of administrative offenses, contains general guidelines for reforming the Administrative Code of the Russian Federation and highlights certain challenging issues that need to be resolved in its forthcoming modernization. At the same time, it does not seem to address all the issues that need to be addressed. Thus, the analysis of administrative-jurisdictional practice of the first instance shows that the protocol on administrative offense is considered by subjects of administrative jurisdiction ( extrajudicial, quasi-judicial, and judicial) as one of the types of evidence in the case of an administrative offence. Moreover, it is not uncommon that such a record is the only evidence on the basis of which an administrative penalty is imposed. And the analysis of administrative and jurisdictional practice of the second and subsequent instances (up to the Supreme Court of the Russian Federation) allows us to conclude that this approach is justified and quite legitimate. But is it really true? And to what extent is it lawful and legitimate to consider the protocol on an administrative offense as evidence in the case of an administrative offense? This paper is devoted to searching for answers to these questions through the prism of understanding of the functional purpose and juridical (lawful) nature of this type of administrativejurisdictional acts.
CALCULATION OF CROSS SECTIONS AND ASTROPHYSICAL S-FACTORS AT 0-5 MeV ENERGY RANGE FOR 8Li (α, n)11B REACTION
Authors: YILDIZ Ercan , SARPÜN İsmail Hakkı 
Published: March 2020

Explaining the origin and evolution of elements is one of the most important problems in astrophysics. The r-process in the current nucleosynthesis scenario; roughly responsible for the production of half of the nuclei heavier than iron. 8Li(α,n)11B reaction plays an important role in the r-process of this scenario because of being a cosmic radiation induced reaction. In particular, it is important to know the change with energy in the low energy zone for testing the accuracy of the model calculations. In this study, the astrophysical S-factors of the 8Li(α,n)11B reaction and the probability of reaction at low energies were calculated in the 0-5 MeV energy range. TALYS 1.8 code was used for the theoretical calculations. The obtained theoretical values were compared with experimental data obtained from the EXFOR database.
Modifying Two-Parameter Ridge Liu Estimator Based on Ridge Estimation
Authors: Omara Tarek Mahmoud 
Published: March 2020

In this paper, we introduce the new biased estimator to deal with the problem of multicollinearity. This estimator is considered a modification of Two-Parameter Ridge-Liu estimator based on ridge estimation. Furthermore, the superiority of the new estimator than Ridge, Liu and Two-Parameter Ridge-Liu estimator were discussed. We used the mean squared error matrix (MSEM) criterion to verify the superiority of the new estimate. In addition to, we illustrated the performance of the new estimator at several factors through the simulation study.
Analisis Motor Ability Terhadap Keterampilan Teknik Pada Permainan Futsal Murid SD Rama Sejahtera Kecamatan Panakukang Kota Makassar
Authors: Sutirta Habibi , Abdul Karim Abdurrauf 
Published: March 2020

The research is correlational and inferential, so it is necessary to design and examine the contribution of strength, speed, agility, and explosive power toward technical skill in futsal. The results of the research reveal that (1) there is significant contribution of strength towards students' Technical Skillin futsal at SD Rama Sejahtera Kecamatan Panakukang Kota Makassar by 50,8% proved from the result of analysis which obtained observation regression value (Ro) = 28,903 (p<0,05) with determination coeffiecient by 0,508. (2) there is significant contribution of speed towards students' technical skill in futsal at SD Rama Sejahtera Kecamatan Panakukang Kota Makassar by 38,8% proved from the result of analysis which obtained observation regression value (Ro) = 17,730 (p<0,05) with determination coeffiecient by 0,388. (3) there is significant contribution of agility towards students' technical skill in futsal at SD Rama Sejahtera Kecamatan Panakukang Kota Makassar by 28,0% proved from the result of analysis which obtained observation regression value (Ro) = 10,914 (p<0,05) with determination coeffiecient by 0,280. (4) there is significant contribution of explosive power towards students' technical skill in futsal at SD Rama Sejahtera Kecamatan Panakukang Kota Makassar by 62,3% proved from the result of analysis which obtained observation regression value (Ro) = 46,194 (p<0,05) with determination coeffiecient by 0,623. (5) there are strength, speed, agility, and explosive power contribution towards students' technical skill in futsal at SD Rama Sejahtera Kecamatan Panakukang Kota Makassar by 66,9% proved from the result of analysis which obtained observation regression value (Ro) = 12,619 (p<0,05) with determination coeffiecient by 0,699.
Key words: Motor ability, technique skill, futsal
Effect of Dopant Concentration on the Structural, Optical and Sensing Properties of (SnO2)1-x(TiO2:CuO)x Sprayed Films
Authors: Et al. Mahmood 
Published: March 2020

Spray pyrolysis technique was subjected to synthesized (SnO2)1-x (TiO2: CuO) x Thin films on different substrates like glass and single crystal silicon using. The structure of the deposited films was studied using x-ray diffraction. A more pronounced diffraction peaks of SnO2 while no peaks of (CuO , TiO2 ) phase appear in the X-ray profiles by increasing of the content of (TiO2 , CuO) in the sprayed films. Mixing concentration (TiO2 , CuO) influences on the size of the crystallites of the SnO2 films ,the size of crystallites of the spray paralyzed oxide films change in regular manner by increasing of (TiO2 , CuO) amount. The effect of mixing concentration on the optical properties of the films was also investigated. The reflectance and transmittance spectra in the wavelength range (300-1100) nm were employed to determine the optical properties such as energy band gap (Eg) and refractive index (n), extinction coefficient (k) , real and imaginary parts of dielectric constants (ε1, ε2) for (SnO2)1-x(TiO2:CuO)x films. The energy band gap omit of which showed reduction from (3.65 to 2.2) eV by reducing of SnO2 amount from (100 to 70) % .The reduction of energy band gap was ascribed to the new tail states introduced in the band gap of tin oxide. The sensitivity of the prepared sensor film was determined resistance difference of the films when exposed to oxidizing gas. The data declared that the mixed SnO2 films have better sensitivity in comparison with unmixed films.
Properties of a Complete Fuzzy Normed Algebra
Authors: Et al. Kider 
Published: March 2020

The aim of this paper is to translate the basic properties of the classical complete normed algebra to the complete fuzzy normed algebra at this end a proof of multiplication fuzzy continuous is given. Also a proof of every fuzzy normed algebra without identity can be embedded into fuzzy normed algebra with identity and is an ideal in is given. Moreover the proof of the resolvent set of a non zero element in complete fuzzy normed space is equal to the set of complex numbers is given. Finally basic properties of the resolvent space of a complete fuzzy normed algebra is given.
Effects of Educational Interventions on Oral Hygiene: A Systematic Review and Meta-Analysis
Authors: Dadipoor Sakineh , Ghaffari Mohtasham , New Mahsa Mortazavi , Alipour Abbas , Safari-Moradabadi Ali 
Published: March 2020

AbstractBackground: The objective of this study is to evaluate the effects of school based oral health interventions programs on students’ oral hygiene, in developing countries through systematic review and meta-analysis. Methods: Our investigation was conducted in electronic databases including MEDLINE Ovid), Embase Ovid, Scopus), Web of Science from 2000 to march 2018.The data were extracted based on a standard data collection form specific to observational studies, and entered into RevMan 2014. Inclusion criteria included individually randomized controlled trials (RCTs) or cluster-RCTs including quasi- experimental studies that were related to oral health interventions. Software RevMan 2014was used for meta-analysis. A meta-analysis was carried out using random-effects models. Results: Twelve studies of students in this review finally entered the study including five individual RCTs, four cluster-RCTs, and three quasi-experimental studies. The intervention study period ranged from 1 month to 9 month. Interventions described in the studies briefly included oral health education with activities such as lectures, albums, slides, pamphlets, posters, and role playing. Meta-analyses showed a significant difference in knowledge (SMD 3.31, 95% CI 2.52 to 4.11; I 2 = 98; P < 0.001), attitude (SMD 1.99, 95% CI 0. 43 to 3.54; I 2 = 99; P < 0.001), behavior (SMD 4.74, 95% CI 3.70 to 5.77; I 2 = 99; P < 0.001), plaque index (SMD -1.01, 95% CI -1.50 to -0. 51; I 2 = 97; P < 0.001) and Gingival index (SMD 0. 33, 95% CI -0. 36 to 1. 02; I 2 = 98; P = 0.34) for students receiving educational interventions compared to those receiving usual care . Discussion: The systematic review concludes that educational interventions are effective for improving oral health knowledge, attitudes, behaviors, etc., which could potentially lead to improved oral health, reduced oral diseases, and reduced costs from treating oral diseases.
How does neighborhood psychosocial interventions affect the link between living alone and psychological disorders in later life?
Authors: Gyasi Razak M , Abass Kabila , Adu-Gyamfi Samuel 
Published: March 2020

Abstract
Background: Social isolation is widespread and strongly associated with deleterious health-related outcomes across the life course in low- and middle-income settings. Despite this broad base of knowledge, there is little reported research on the pathways linking living alone to later life psychological state. Thus, the aim of this study was to examine the influence of living alone on psychological disorder in middle- aged and older people and to explore the protective role of potential psychosocial strategies such as social participation and physical activity. Methods: We used cross-sectional data from a 2016/2017 Aging, Health, Psychological Wellbeing and Health-seeking Behavior Survey involving nationally representative sample of 1200 adults aged 50+ years in Ghana. The study focused on a latent measure of Kessler Psychological Distress Scale (K10) and on the General Practice Physical Activity Scale (GPPAS). Ordinary Least Squares (OLS) regression models evaluated the effect of living alone interactively with neighborhood engagement measures on the indicator of mental disorder. Results: The results showed that living alone was independent predictor of psychological distress in the overall sample, among females, urban dwellers and all age groups. However, physical activity and social participation significantly buffered against these associations. In the stratified analysis, physical activity moderated the association for males, rural-dwellers and those 65+ years whilst social participation modified the association for females, urban-dwellers and those 50-64 years. Conclusions: Psychosocial mechanisms strongly attenuate the positive association of living alone with the risk of psychological distress in older age. These findings may inform intervention initiatives targeted at improving mental health of chronically detached and isolated older people.
Preparation of uniformly labelled 13C- and 15N-plants using customised growth chambers
Authors: Ceranic Asja , Doppler Maria , Büschl Christoph , Parich Alexandra , Xu Kangkang , Koutnik Andrea , Bürstmayr Hermann , Lemmens Marc , Schuhmacher Rainer 
Published: March 2020

Abstract
Background Stable isotopically labelled organisms found wide application in life science research including plant physiology, plant stress and defense as well as metabolism related sciences. Therefore, the reproducible production of plant material enriched with stable isotopes such as 13 C and 15 N is of considerable interest. A high degree of enrichment (>96 atom%) with a uniformly distributed isotope (global labelling) is accomplished by a continuous substrate supply during plant growth/cultivation. In the case of plants, 13 C-labelling can be achieved by growth in 13 CO 2(g) atmosphere while global 15 N labelling needs 15 N- containing salts in the watering/nutrient solution. Here, we present a method for the preparation of 13 C and 15 N labelled plants by the use of closed growth chambers and hydroponic nutrient supply. The method is exemplified with durum wheat. Results In total, 330 g of globally 13 C- and 295 g of 15 N labelled T. durum wheat was produced during 87 cultivation days. For this, a total of 3.88 mol of 13 CO 2(g) and 58 mmol of 15 N were consumed. The degree of enrichment was determined by LC-HRMS and ranged between 96-98 atom% for 13 C and 95-99 atom% for 15 N, respectively. Additionally, the isotopically labelled plant extracts were successfully used for metabolome-wide internal standardisation of native T.durum plants. Application of an isotope-assisted LC-HRMS workflow enabled the detection of 652 truly wheat-derived metabolites out of which 143 contain N. Conclusion A reproducible cultivation which makes use of climate chambers and hydroponics was successfully adapted to produce highly enriched, uniformly 13 C- and 15 N-labelled wheat. The obtained plant material is suitable to be used in all kinds of isotope-assisted research. The described technical equipment and protocol can easily be applied to other plants to produce 13 C-enriched biological samples when the necessary specific adaptations e.g. temperature and light regime, as well as nutrient supply are considered. Additionally, the 15 N-labelling method can also be carried out under regular glasshouse conditions without the need for customised atmosphere.
Definition of the perceived self-care ability in stroke survivors living at home in the Middle East : a protocol for a Systematic Literature Review
Authors: Jafari-golestan Nasrin , dalvandi asghar , Hosseini Mohammadali , Fallahi-Khoshknab Masoud , Ebadi Abbas , Rahgozar Mahdi , Sidani Souraya , Keshtkar Abbas 
Published: March 2020

Abstract
Background : A stroke brings about several adverse outcomes so that a stroke patient faces numerous physical, and sensory together with cognitive, and psychological disorders. These disorders influence patients’ perceived self-care ability. There is no agreement on what the perceived self- care ability in stroke patients living at home is. Because of various cultures and medical systems, such an ambiguity may be more serious when it comes to the Middle East countries compared to advanced ones. This Systematic Literature Review aims to summarize the literature on this concept and propose a definition which might help similar research on the stroke in the future.
Methods : The databases PubMed, Scopus, CINAHL, PsycINFO, PEDro, Web of Science, ProQuest, ScienceDirect, Index Medicus, EMRO, Google Scholar, Magiran, SID, IranDoc, and the stroke-related literature will individually be queried to retrieve related literature on the perceived self-care ability in stroke patients, using subject headings and appropriate MeSH terms. The inclusion and exclusion criteria will be developed and refined by the research team. Two independent reviewers will participate in each search stage including abstract/title and full-text screening, study selection, data collection, or quality assessment steps. We will restrict our search to articles published in the English language in biomedical journals since 1970 to 2018. The result will be tabuled, and meta-synthesis will be performed.
Discussion: The results of this systematic literature review can present a more accurate definition of perceived self-care ability in stroke patients living at home in Middle East countries.
Systematic review registration: CRD42018100520
Keywords: Perceived Self-care Ability, Stroke, Home, Systematic Literature Review, Definition, Middle East
Development and evaluation of an indirect ELISA for the detection of Mycoplasma hyopneumoniae natural infection but not inactivated bacterin vaccination
Authors: Ding Honglei , Wen Yukang , Xu Zuobo , Tlili Chaker , Tian Yaqin , Wang Zhaodi , Ning Yaru , Xin Jiuqing 
Published: March 2020

Abstract
Background: Mycoplasma hyopneumoniae is the primary pathogen of enzootic pneumonia (EP). Vaccination with inactivated bacterin is the most popular and practical measure to control EP. However, these commercial vaccines have a limited effect on the transmission of microorganism and cannot prevent colonization. Therefore, after immunization with inactivated bacterin, M. hyopneumoniae colonized on the respiratory tract and lungs stimulates the humoral immune responses and produce IgG and IgA antibodies. ELISA is a widely used serological method to detect M. hyopneumoniae antibodies. However, commercial IgG ELISA kit cannot distinguish between inactivated bacterin-induced hyperimmune sera and convalescent sera stimulated by natural infection. SIgA ELISA method is laborious for nasal swab collection, and the amount of each swab sample obtained from the nasal cavity is less compared to the serum sample. Establishment of a discriminative ELISA detecting humoral IgG from convalescent sera but not hyperimmune sera facilitates to evaluate the natural infection of M. hyopneumoniae after inactivated bacterin vaccination. Result: We expressed and purified a recombinant protein named Mhp366-N which contains an epitope recognized by the convalescent sera but not hyperimmune sera. The developed discriminative IgG-ELISA could discriminate between inactivated bacterin-induced hyperimmune sera and convalescent sera, and was reproducible, sensitive, and specific to M. hyopneumoniae antibody produced by natural infection. Compared to sIgA-ELISA method, discriminative IgG-ELISA was more convenient to detect IgG antibody from sera than IgA from nasal swabs, although it has limited sensitivity in the early stages of infection. Additionally, to some extent, it has a potential to avoid the interference of maternally derived IgG antibodies. Conclusions: The established discriminative IgG-ELISA was efficient to judge the serological IgG antibodies induced from natural infection or inactivated vaccine stimulation and provided a useful method to investigate and evaluate the live organism infection after the application of inactivated bacterin.