bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Foot Intrinsic Associated Factors of Ankle Sprains among a Random Sample of Tunisian Athletes: Across-Sectional Study
Authors: Taghouti Emna , Gallas Meriam , Maatoug Hana , Khachnaoui Faycel 
Published: December 2020

Abstract
Objective To determine the prevalence of ankle sprains and its associated factors in athletes. Methods This was a cross sectional descriptive study conducted among a random sample of 107 athletes. The subjects were recruited from 6 different associations in Sousse, Tunisia. Demographic, medical and foot characteristics were collected using a medical file completed by a validated, self administered questionnaire to verify ankle instability. All components of this study were approved by a research ethic committee, and all participants gave informed consent at every stage. Data entry and analysis were performed using SPSS 20 Software. The level of significance was set at p <0.05. ResultsThe prevalence of ankle sprain was 71%. The associated factors were; the weight (p=0.033), the type of sport (p=0.038), the profile of the athlete (p=0.006), the unipodal static balance (p= 0.006), the limitation of the joint mobility (p=10-6), the ligament laxity (p<0.05), the muscular force especially the eversor muscle (the long fibular) (p<0.05) and the inversor muscle (the posterior tibial) (p<0.05) and the ankle instability (p<0.05). Conclusion Ankle sprains remain a frequent trauma in Tunisia. This injury must be taken into consideration and treated with a multidisciplinary approach (physicians, podiatrists, physiotherapists and physical trainers...) in order to lower its occurrence.
Linking Neuroinflammation and Extracellular Free Water in HIV Infection: A Longitudinal Study
Authors: Uddin Md Nasir , Faiyaz Abrar , Wang Lu , Zhuang Yuchuan , Murray Kyle D , Descoteaux Maxime , Tivarus Madalina E. , Weber Miriam T. , Zhong Jianhui , Qiu Xing , Schifitto Giovanni 
Published: December 2020

Abstract
Background

Initiation of combination antiretroviral therapy (cART) reduces inflammation in HIV-infected (HIV+) individuals. Recent studies demonstrated that diffusion MRI based extracellular free water (FW) modeling can be sensitive to neuroinflammation. However, no studies to date have investigated the FW in HIV infection, its temporal evolution, nor its association with brain-derived blood markers.
Methods

Ninety-six age-matched participants underwent brain MRI and clinical and neuropsychological assessments at baseline. HIV- participants underwent follow-up evaluation annually for two years while HIV + participants were seen 12 weeks after initiating cART and annually thereafter. Whole brain grey and white matter FW measures were compared between groups and correlated with clinical characteristics and cognitive scores. In addition, several pre-specified subcortical grey and white matter regions-of-interest (ROIs) were explored.
Results

At baseline, FW was significantly elevated in grey and white matter in cART-naïve HIV + participants compared to HIV- participants. Similarly, at baseline, HIV + participants had increased neurofilament light chain (NfL) values that correlated with FW and CD4 count, and decreased cognitive performance compared to HIV- participants. FW decreased in grey and white matter in HIV + participants after 12 weeks of cART treatment. 12-week cART treatment was also associated with a decrease in NfL and improvement in cognitive performance. Linear mixed effects regression models also revealed that FW was significantly reduced in most ROIs after 12 weeks of cART treatment. No significant FW differences were noted between the HIV + and HIV- participants at 1 and 2-year follow-up.
Conclusions

FW elevation in cART-naïve HIV + participants is likely due to neuroinflammation. The correlation between FW and NfL and the improvement in both FW and NfL after 12 weeks of cART treatment further reinforces this conclusion. The longer follow-up at 1 and 2 years suggests that cART helped control neuroinflammation as inferred by FW. Therefore, FW could be used as a biomarker to monitor HIV-associated neuroinflammation.
The Psychological Processes of Classic Psychedelics in the Treatment of Depression: A Systematic Review Protocol
Authors: Johansen Lauren , Liknaitzky Paul , Nedeljkovic Maja , Mastin-Purcell Lisa , Murray Greg 
Published: December 2020

Abstract
BackgroundThere is currently renewed interest in the use of psychedelic therapy in the treatment of psychiatric disorders, including depression. The proposed systematic review will aim to identify, evaluate and summarise the psychological processes of change underlying psychedelic therapy for depression in the current literature and consider the implications these processes may have on the psychotherapy component of treatment. MethodsScopus, PsycINFO, PubMed and Web of Science databases will be searched using relevant terms. Studies will be included if they discuss the use of a classic psychedelic to treat depression symptomology in an adult population and report or propose psychological processes responsible for depression symptom change. Two authors will independently screen articles, complete quality assessment tools and conduct data extraction. Empirical and non-empirical research will be extracted and synthesised separately. A narrative synthesis approach will be used to report psychological processes identified in the literature. DiscussionThis systematic review will be the first to collate available evidence on the psychological processes associated with psychedelic therapy for depression. The preliminary nature of this research field is expected to result in the review having several limitations, namely heterogeneity between studies and a lack of empirical research. We intend for this review to present the current state of the literature, identify gaps and generate candidate variables that warrant further investigation. Systematic Review Registration﻿PROSPERO CRD42020197202
Prostate Cancer Awareness Among Women: A Mixed-methods Systematic Review
Authors: Wiafe Ebenezer , Mensah Kofi Boamah , Mensah Adwoa Bemah Boamah , Bangalee Varsha , Oosthuizen Frasia 
Published: December 2020

Abstract
Background: With the burden of prostate cancer, it has become imperative to exploit cost-effective ways to tackle this menace. Women have demonstrated their ability to recognize early cancer signs and it is therefore relevant to include women in strategies to improve the early detection of prostate cancer. This systematic review seeks to gather evidence from studies that investigated women’s knowledge about; (1) the signs and symptoms, (2) causes and risk factors, and (3) the screening modalities of prostate cancer. Findings from the review will better position women in the fight against the late detection of prostate cancer.Methods: The convergent segregated approach to the conduct of mixed-methods systematic reviews was employed. Five databases namely; MEDLINE (EBSCOhost), CINAHL (EBSCOhost), PsycINFO (EBSCOhost), Web of Science, and EMBASE (Ovid) were searched from January 1999 to December 2019 for studies conducted with a focus on the knowledge of women on the signs and symptoms; the causes and risk factors; and the screening modalities of prostate cancer.Results: Of 2201 titles and abstracts screened, 22 full-text papers were retrieved and reviewed, and 7 were included: 3 quantitative, 1 qualitative, and 3 mixed-methods studies. Both quantitative and qualitative findings indicate that women have moderate knowledge of the signs and symptoms; and the causes and risk factors of prostate cancer. However, women recorded poor knowledge about prostate cancer screening modalities or tools.Conclusions: Moderate knowledge of women on the signs and symptoms, and the causes and risk factors of prostate cancer were associated with education. These findings provide vital information for the prevention and control of prostate cancer and encourage policy-makers to incorporate health promotion and awareness campaigns in health policies to improve knowledge and awareness of prostate cancer globally.Systematic Review registration number: Open Science Framework (OSF) registration DOI: https://doi.org/10.17605/OSF.IO/BR456
The Conflict with non-HRM Department: Reason, Mediation, Result
Authors: Chen Zhisheng 
Published: December 2020

Abstract
Background: When the human resources department implements human resources policies and systems, there will be various obstacles from other departments. Because human and non-human departments are different in departmental goals and division of tasks, conflicts in human resource management are likely to occur, which affects the realization of organizational goals.Methods: This article constructs a conflict model between the two parties and studies the origin of the conflict between the HRM and non-HRM sectors, including personnel, policies, and systems. It also proposes ways to resolve conflicts, such as communication, role exchange, business process consensus, focus on organizational goals, and political skills.Results: The research started by investigating the origin of conflicts between human resources and non-human resources departments within the organization and analyzed the sources and important effects of conflicts. In response to the source of these problems, corresponding arbitration measures have been proposed. After the conflict between the two parties is resolved, it is beneficial to achieve a win-win result for employees, departments, and organizations.Conclusions: Lack of inter-departmental understanding and negative conflicts will only cause the human resources department to fail to achieve the expected goals. The purpose of these measures is to improve the relationship between departments and reduce unnecessary conflicts. Once this type of conflict is resolved reasonably and properly, it will also have a positive impact on the performance of different levels.
Narrow Substrate Requirements Alongside Rapid Substrate Turnover for Wood-Inhabiting Fungi: A Case Study of Pleurotus Calyptratus (Agaricales, Basidiomycota) in Ukraine
Authors: Prylutskyi Oleh , Yatsiuk Iryna , Savchenko Anton , Kit Maryna , Solodiankin Oleksii , Schigel Dmitry 
Published: December 2020

Abstract
BackgroundPleurotus calyptratus is a wood-inhabiting oyster mushroom which produces fruiting bodies on logs, stumps and branches of both dead and living Populus tremula and P. alba. Easily recognisable in the field fruit bodies and strict and steady fruiting period make this species an attractive model object for investigations of ecology of wood-inhabiting fungi. This fungus is rather common in Ukraine, but considered rare in many other European countries.To explore species biology in relation to its rarity issues, we analyzed substrate requirements and habitat supply for P. calyptratus in two sites in Eastern Ukraine, as well as monitored patterns of fruit body production in three large aspen stands over 6 years. In addition, patterns of mycelial presence of P. calyptratus mycelia were studied in living aspen trees using custom species-specific primers.ResultsStudy demonstrates potential suitability of a wide range of life / decomposition stages of aspen or white poplar tree trunks for P. calyptratus. This window of suitability, however, is rather short: dying of freshly dead trees, rarely exceeding two years) regardless of tree age, volume, position or other parameters. Moreover, mycelium presence of P. calyptratus was detected in the living tissues of host trees. These findings supported hypotheses of early substrate colonization and latent mycelial development of P. calyptratus before the substrate reached a stage suitable for fructification.ConclusionsConfirmed by a combination of fruit body survey and detection of mycelial DNA, P. calyptratus demonstrates an ecological strategy which combines both strict substrate requirements and rapid substrate turnover. We suppose that such a strategy may be widely distributed among wood-inhabiting agarics.
3D Printing of a Bio-Based Ink Made of Cross-Linked Cellulose Nanoﬁbrils With Various Metal Cations
Authors: Mietner Jakob , Jiang Xuehe , Edlund Ulrica , Saake Bodo , Navarro Julien 
Published: December 2020

Abstract
In this work, we present an approach to cross-link cellulose nanofibrils (CNFs) with various metallic cations (Fe3+, Al3+, Ca2+, and Mg2+) to produce inks suitable for three-dimensional (3D) printing application. The printability of each hydrogel ink was evaluated, and several parameters such as the optimal ratio of Mn+:TOCNF:H2O were discussed. CNF suspensions were produced by mechanical disintegration of cellulose pulp with a microfluidizer and then oxidized with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO). Finally, metal cations were introduced to the deprotonated TEMPO-oxidized CNF (TOCNF) suspension to cross-link the nanofibrils and form the corresponding hydrogels. The performances of each gel-ink were evaluated by rheological measurements and 3D printing. Only the gels incorporated with divalent cations Ca2+ and Mg2+ were suitable for 3D printing. The 3D printed structures were freeze-dried and characterized with Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The better interaction of the TOCNFs with the divalent metallic cations in terms of printability, the viscoelastic properties of the inks, and the variation trends owing to various metal cations and ratios are discussed.
GMP-compliant Manufacturing Process of an Advanced Therapy Medicinal Product Based on Conjunctival Epithelial Cells
Authors: Bertolin Marina , Ferrari Stefano , Breda Claudia , Ferrari Barbara , Ponzin Diego , Barbaro Vanessa 
Published: December 2020

Abstract
Background. Conjunctival epithelial stem cell therapy represents a potential and valuable therapeutic option for people suffering from conjunctival disorders. We recently developed a research protocol for the ex vivo cultivation of conjunctival epithelial cells. However, manufacturing and release of any Advanced Therapy Medicinal Product (ATMP) must be designed and planned according to the Good Manufacturing Practices (GMPs) guidelines. GMPs require the development and validation of properly defined manufacturing processes, analysis methods and process validations. Our previous experience with GMP-cultured corneal epithelial stem cells for clinical application on patients with limbal stem cell deficiency led us to set up a protocol for cultivation of conjunctival cells with standards complying with the requests for clinical studies. The major challenge for cell-based products is to develop manufacturing processes while maintaining the critical quality parameters in terms of safety, identity, purity and potency.Results. The manufacturing process was re-designed in order to include all the quality control assays needed for the release of any ATMP, i.e., sterility, morphology, cell viability, dose, cell identity and impurities, potency, lack of pyrogens, mycoplasma and viral detection. Methods and acceptance values were set for all the assays. Quality control assays to evaluate safety and efficacy were also investigated.Conclusion. Here, we describe the main phases of the manufacturing process of a conjunctival stem cell-based product to use in clinical applications. Such characterization is crucial for the preparation of documents and dossiers needed by the competent authorities to start a phase I clinical study on patients with conjunctival disorders. The procedure necessary to reach the marketing authorization of such a new cell-based product is still long, but, if reliable and validated, we believe that, in the near future, patients with conjunctival disorders might have a new treatment based on transplantation of autologous cultured conjunctival epithelial stem cells.
Organophosphorus Pesticide Malathion and Immunotoxicity: A More Sensitive Toxicological Target and Current Recommendations
Authors: Lou Minhan , Yong Ling , Mao Weifeng , Xiao Xiao , Liang Chunlai , Wang Wei , Yang Hui , Jia Xudong , Liu Zhaoping , Wang Yin , Li Ning , Song Yan 
Published: December 2020

Abstract
Background Malathion has been wildly used in agriculture and household pest control for years and can affect human health through drinking water and dietary exposure. This study was to investigate the immunotoxicity of malathion (MLT）on BALA/c mice for the purpose of providing a scientific basis for pesticides registration management of MLT and other pesticides. Methods Female mice were randomly divided into five groups. Both the negative control and the positive control groups of mice were daily gavage with corn oil, and those in the positive control group were intraperitoneal injected with 200 mg/kg bw of cyclophosphamide (CY) 24 h before the end of the study. In the dosage groups, MLT were daily gavage at doses of 16, 65 and 258 mg/kg bw for 30 days, respectively. After exposure, the body weight, the absolute and relative weight of organs, the hematology and clinical chemistry parameters, the splenocyte number, the bone marrow cell classification, histopathology, as well as the cellular immunity, humoral immunity, and non-specific immunity functions of mice were studied. Comparisons between multiple groups were carried out by using one-way ANOVA followed by Bonferroni post hoc comparisons tests when equal variances assumed and Dunnett’s T3 post hoc tests when equal variances assumption was not met.ResultsCompared with the negative control group, the low dose of MLT significantly reduced the levels of IL-10, neutrophil, polychromatic erythroblast and monocyte series (P<0.05)，induced atrophy in white pulp of spleen (1/10), which showed an immunosuppression in mice，and increased the absolute and relative weight of thymus (P<0.05). Inhibition of the PFC response, liver injury and thymus atrophy were observed in the high-dose group. What’s more, the IgG level was abnormally elevated with the increase of dose and presented a dose-response relation (P<0.05). ConclusionsThe immunotoxicity of low-dose of MLT is clear from the evidence and the LOAEL of MLT is preliminarily considered to be 16 mg/kg bw. It is much lower than that of the NOAEL (29 mg/kg bw) based on a 2-year chronic toxicity test and carcinogenicity test in rats, which was used to derive the ADI by Joint WHO/FAO Meeting on Pesticide Residues (0.3 mg/kg bw). It indicates that the immune system is a more sensitive target of MLT toxicity.
Using a Screening Toolkit to Determine the Prevalence of Non-Communicable Diseases in an Urban Slum of Mumbai, India: A Cross-Sectional Study
Authors: Rungta Ria , DeWan Andrew T. , Gawali Vijaykumar , Witte Luc de , Hassan Saria 
Published: December 2020

Abstract
Background: Higher than national rates of non-communicable diseases have been found in some urban slums of India. This has been attributed to potentially lower levels of education and decreased access to preventative care. We sought to assess the prevalence of NCDs in a Mumbai slum compared to national averages and understand the association with social determinants of health.Methods: We used a screening toolkit called THULSI (Toolkit for Healthy Urban Life in Slums Initiative) in a community health-camp setting to screen 266 slum dwellers for obesity (BMI above 25 kg/m2), elevated blood pressure (SBP > 120 mm of Hg and DBP > 80 mm of Hg), and elevated blood glucose (RPG > 200 mg/dL). A health survey was administered to understand the demographic data and information about health-seeking behavior of the slum dwellers. The collected data was analyzed to determine the prevalence of each condition and associations with different social determinants of health such as literacy and education level, diagnosis and marital status, age, gender, place of care, employment, availability of toilet, and languages spoken. Results: Of the screened population, 72.6% had elevated blood pressure, 9.0% had elevated blood glucose, 63.2% were obese, and 12.4% were overweight. These rates were 2.81, 1.04, and 3.84 times higher than the national averages, respectively. Of the study population, 26.7% had one condition, 53.4% had two conditions, and 7.9% had all the three conditions we screened for. Male gender (OR: 3.33, 95% CI: 1.37, 8.07) and older age (35-49 years OR: 3.03, 95% CI: 1.52, 6.05, 49-63 years OR: 7.22, 95% CI: 3.06, 17.05, >= 63 years OR: 6.82, 95% CI: 2.12, 22.00) were associated with increased odds of elevated blood pressure, not being previous diagnosed (OR: 0.04, 95% CI: 0.01, 0.13) was associated with lower odds of elevated blood glucose, and older age (35-49 years OR: 2.51, 95% CI: 1.21, 5.21, 49-63 years OR: 4.95, 95% CI: 2.06, 11.92) was associated with increased odds of obesity.Conclusion: We found higher than national rates of the NCDs and high comorbidity in the screened slum population of Mumbai. This signifies the need for screening services and the importance of awareness and education in this population.
Association Between Happiness and Objective/Subjective Economic Status Among Older Adults in Myanmar
Authors: Sasaki Yuri , Shobugawa Yugo , Nozaki Ikuma , Takagi Daisuke , Nagamine Yuiko , Funato Masafumi , Chihara Yuki , Shirakura Yuki , Lwin Kay Thi , Zin Poe Ei , Bo Thae Zarchi , Sone Tomofumi , Win Hla Hla 
Published: December 2020

Abstract
BackgroundFew studies have examined whether objective or subjective economic status (ES) has a greater effect on the happiness of older adults in developing countries with ageing populations. This study examined whether objective/subjective economic status (ES) is associated with happiness in older adults in Myanmar.MethodA multistage, random sampling procedure and face-to-face interviews were conducted in urban and rural areas in Myanmar. The happiness of 1,200 participants aged 60+ was evaluated using a single happiness score of 0 (very unhappy) to 10 (very happy). The wealth index, used as an objective economic indicator, was calculated from household asset items. Subjective economic status was assessed by asking “Which of the following best describes your current financial situation in light of general economic conditions?” The possible responses ranged from (1) very difficult to (5) very comfortable. ResultsThe mean happiness score was lower among participants with low objective and subjective ES than among those with medium or high objective ES (6.24 versus 6.80 points, p < 0.001) and average or higher subjective ES (5.62 versus 6.83 points, p < 0.001), respectively. Both low objective and subjective ES were negatively associated with happiness after adjusting for confounding variables (B: -0.41, 95% confidence interval [CI]: -0.69, -0.13 and B: -0.71, 95% CI: -1.00, -0.42, respectively) and stratification by region (low objective ES, urban: B: -0.52, 95% CI: -1.03, -0.02; low subjective ES, urban: B: -0.50, 95% CI: -0.96, -0.03; low objective ES, rural: B: -0.37, 95% CI: -0.73, -0.02; and low subjective ES, rural: B: -0.80, 95% CI: -1.18, -0.41). ConclusionsIn Myanmar, both objective and subjective ES might influence happiness among older adults. Although they had a similar impact on happiness in urban areas, subjective ES had a stronger impact in rural areas. Interventions for promoting happiness in older adults should consider differences in how objective/subjective ES impacts happiness in different regions, and focus should be placed not only on improving objective ES but also subjective ES in society.