bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribuição de uma controvérsia sobre transgenia para a formação crítica de alunos do ensino médio
Authors: Ferreira Spolidoro Marcello Miranda , Chrispino Alvaro 
Published: September 2020

Este artigo apresenta um estudo de caso cujo objetivo foi investigar o impacto de uma controvérsia no entendimento do tema transgenia em estudantes de ensino médio de um colégio público. A prática foi pensada com intenção de explorar cinco dimensões de um campo conhecido como Pensamento Crítico. O tema transgenia foi escolhido de forma estratégica, pois serviu de base para tratar de questões tecnocientíficas relativas ao campo CTS de ensino. A metodologia utilizada para coleta de dados contou com a aplicação de questionários (PIEARCTS e HCTA) pré e pós controvérsia, além do registro das falas dos participantes durante e após a prática. Foram aplicados os mesmos questionários em uma turma controle, porém, sem a realização da controvérsia. Os resultados mostraram não haver diferenças significativas entre os índices gerados pelo PIEARCTS, mas sim para certas dimensões do Pensamento medidas pelo HCTA. Neste caso, para identificar as diferenças, foram realizadas análises globais dos questionários, seguido de análises específicas por categorias e, finalmente, análises específicas pelo tipo de pergunta. Quanto ao registro das falas dos estudantes, consideramos que estas foram fundamentais para identificar criticidade na maneira de encarar uma temática tão polêmica quanto à dos transgênicos, favorecendo reflexões complementares a respeito da metodologia aplicada.
Current data on early diagnosis of West syndrome. Electroencephalographic evolution of hypsarrhythmia
Authors: Aysina Victoriya A. , Kuzenkova Lyudmila M. , Kozhevnikova Olga V. 
Published: September 2020

The review of current ideas about the early diagnosis of West syndrome is presented in terms of electroencephalography data based on a characterization of the period of prehypsarrhythmia preceding the appearance of the pattern of hypsarrhythmia. There are considered examples of our observations. Also, our data from a study of a group of children with hypsarrhythmia are described. A lot of studies of clinical manifestations and neurophysiological aspects of West syndrome have been conducted after the onset of clinical manifestations in the form of spasms, and variants of the transformation of West syndrome have been reported. On the other hand, very few studies of its clinical and electroencephalographic evolution have been conducted since the prehypsarrhythmic stage. The opportunity to reliably identify this precursor period would be the first step towards early diagnosis of West syndrome. Early prediction and subsequent intervention in West syndrome will have significant predictive value. A retrospective analysis of 68 electroencephalographic studies was conducted at the
National Medical Research Center for childrens health. Based on the preliminary data of our study, we can distinguish a period of 1 to 3 months, during which in most children, the EEG pattern from prehypsarrhythmic in the form of multi-regional epileptiform activity with an average representation index or regional epileptiform activity in the parietal-occipital-posterior parts with a low representation index transforms to a pattern of hypsarrhythmia. It seems appropriate to recommend that newborns with structural brain disorders, premature infants, children with multi-regional epileptiform activity, with regional epileptiform activity in the parietal-occipital-posterior parts (even low index) to be observed with regular video EEG monitoring at least once every 1-2 months, to early detect the pattern of hypsarrhythmia and West syndrome.
Method of the Cyclotorsion Error Compensation for Myopic Astigmatism during SMILE Surgery
Authors: Gamidov G. A. , Mushkova I. A. , Kostenev S. V. , Gamidov A. A. 
Published: September 2020

Purpose: to develop an effective and safe method of cyclotorsion compensation, to improve the clinical and functional results of the of myopic astigmatism correction with SMILE surgery.Patients and methods: Two equivalent groups of 30 people (30 eyes) were formed with cyclotorsion from ±5 degrees («Standard» and «Verion»). The correction for cyclotorsion was carried out only in the «Verion» group. Before the laser-refraction surgery, all eyes were examined using «Verion» image guided system (Alcon, USA) to determine cyclotorsion. In the «Verion» group, the obtained cyclotorsion data was used to aligement the astigmatism axis by Introducing into the «Visumax» femtolaser system. Further, the operation was carried out according to the standard protocol. At 3 months after SMILE surgery, all patients were examined by a UDVA, CDVA, objective refraction. Furthermore, efficiency and safety, as well as vector analysis of corneal astigmatism according to Alpins were calculated indices at 3 months after surgery.Results: The mean and standard deviation of cyclotorsion of the «Standard» and «Verion» groups was 6.16 ± 1.31 D and 6.30 ± 1.36 degrees, respectively (p > 0.05). The increasement of 1 or more UDVA lines was noted at 20 % and 7 %, respectively after 3 months in the «Standard» and «Verion» groups. The safety index (postoperative UDVA / preoperative UDVA) in both groups was not statistically significantly different (p > 0.05). The predictability of the spherical equivalent within ±0.5 D relative to the target refraction (emmetropia) in the «Standard» and «Verion» groups was 70 % and 100 %, respectively. The predictability of the cylindrical component of refraction within ±0.5 D relative to the target refraction (emmetropia) was 40 % and 90 % for the «Standard» and «Verion» groups, respectively (p < 0.05). Difference vector was 1.01 ± 0.59 D in the group «Standard» and 0.64 ± 0.33 D in the «Verion» group (p < 0.05). Correction index was 0.80 ± 0.43 in the «Standard» group and 0.99 ± 0.04 in the «Verion» group (p < 0.05).Conclusions: Сyclotorsion compensation using the «Verion» image guided system is a safe method. It improves the efficiency and predictability of correction myopic astigmatism in patient undergoing to SMILE surgery. This method recommended for patients with cyclotorsion from ±5 degrees and myopic astigmatism from –0.75 D.
Role of Gestational Hypertension and Preeclampsia as Risk Factors for Formation of Vascular Disorders of Retina in Remote Period after Delivery
Authors: Kolenko O. V. , Sorokin E. L. , Khodzhaev N. S. , Pomytkina N. V. , Chizhova G. V. , Pashentsev Ya. E. , Kolenko L. E. 
Published: September 2020

Purpose. To study the correlation between pregnancy, complicated by preeclampsia and gestational hypertension (GH), and formation of retinal vascular and optic nerve disorders in the late postpartum period.Patients and methods. 231 women with different previous pregnancy variants of pathology. Exclusion criteria — presence of systemic endocrine, autoimmune, rheumatic pathology before pregnancy; bad habits. Four groups were formed. 1st main group: pregnancy with GH. 2nd main group: pregnancy with preeclampsia. 1st comparison group: pregnancy on the background of pre-existing hypertension, without proteinuria. 2nd comparison group: edema and/or proteinuria during pregnancy, without hypertension. The control group — physiological process of pregnancy. Period of ophthalmological examination after pregnancy is 6–12 years.Results. Development of various vascular and ischemic disorders of posterior eye segment occurred in 70 women (30.3 %). The periods of their formation after previous pregnancy varied from 3 to 11 years. Their frequency in the 1st and 2nd main groups was statistically significantly higher. The most common were retinal vein occlusion and post-thrombotic retinopathy. The negative outcomes of transferred GH and preeclampsia are no eliminated with delivery and can manifest next years and even decades after it.Conclusion. Нigh risk factors for development of vascular and ischemic disorders of posterior eye segment are transferred preeclampsia, especially with its early onset (20–24 weeks), or premature birth (26–28 weeks); pregnancy, complicated by GH. The risk of developing this eye pathology is highest in women aged 38–40 years and over.
Application of the Modified Вagolini Test in the Diagnosis of Binocular Vision Disorders
Authors: Rychkova S. I. , Likhvantseva V. G. 
Published: September 2020

The work is devoted to one of the most actual problems of current strabismology — the development of effective ways to study binocular vision.The purpose — to study the effectiveness of the developed modification of the Bagolini test in the diagnostics of binocular disorders.Patients and methods. 240 patients with non-paralytic strabismus aged from 6 to 17 (on average 10.8 ± 0.24) years were observed. There were 190 patients with converging strabismus and 50 patients with diverging strabismus. The control group consisted of 180 children aged also from 6 to 17 (on average 10.9 ± 0.3) years without ophthalmopathology. All children were examined for the character of vision using a Worth-test, the classic Bagolini test (CTB), and the developed modified Bagolini test (MTB). If the patient has a strabismus angle, the study was performed in two variants: without prismatic deviation compensation (under the subjective angle of strabismus — SU) and under full prismatic compensation (under the objective angle of strabismus — OU). For qualitative assessment of binocular vision with MTB, static presentation of the test image was used, for quantitative assessment — alternating (alternate presentation of details corresponding to the right and left eyes).Results. The qualitative evaluation data obtained with the help of MTB made it possible to differentiate patients with non-permanent regional functional scotoma of suppression (FSP) and patients with stable bifoveal fusion among children with binocular vision by color test, and to distinguish patients with regional stable FSP and total FSP among children with monocular vision by color test. In the study under SU, the sensitivity of the method was 97.8 % and specificity 96.2 %, under OU — 96.6 % and 92.7 %, correspondingly. Using quantitative evaluation, it was found that the minimum duration of monocular phases required to eliminate functional inhibition in children with total FSP is twice as long as in children with regional FSP (z = 6,303, df 52, p < 0.001 according to the Mann — Whitney criterion).Conclusion. Thus, the modified Bagolini test developed by us is an effective way of qualitative and quantitative assessment of the state of binocular vision. The method has a high sensitivity and specificity, combines the capabilities of anaglyphic and phase haploscopy, and can be used for a personalized approach to the selection of conditions and modes of functional correction of binocular disorders, as well as for monitoring binocular vision during treatment.
Using of Hypercorrection in Diagnostics and Functional Treatment of Children with Strabismus
Authors: Rychkova S. I. , Likhvantseva V. G. 
Published: September 2020

Conjunctival lymphomas are predominantly extranodal B-cell non-Hodgkin’s lymphomas (NHL), most of them are MALT-lymphomas originating from the mucosa-associated lymphoid tissue. The paper is devoted to the study of the feasibility of using hypercorrection in the functional treatment of children with non-paralytic strabismus.The purpose of this work is evaluation of the effectiveness of hypercorrection in the diagnosis and functional treatment of children with non-paralytic strabismus. Patients and methods. We observed 166 school-age children with friendly strabismus: 140 children with esotropia (134 children with hypermetropic refraction and 6 children with myopic refraction) and 26 children with exotropia (17 children with myopic refraction and 9 children with hypermetropic refraction). The control group of children included 151 school-age children with ametropia without strabismus: 110 children with hypermetropia and 41 children with myopia. Optimal optical correction, accommodation and visual acuity were studied under monocular observation conditions and then under bifixation control using a binarimeter at different distances from the eyes (0.5, 1, and 5 m).Results. In children with esotropia and hypermetropic refraction, the most favorable conditions for the formation of a binocular visual image (BVI) were created using hypercorrection (average values from 2.4 ± 0.06 to 2.8 ± 0.06 D for different distances from the eyes). Children with exotropia and myopic refraction also needed hypercorrection to form BVI (Me = 2.5 [Q1 = 2.0; Q3 = 3.0] D at all distances from the eyes). At the same time, a strong positive correlation was found between the deviation value and the hypercorrection value necessary for the formation of BVI in children with both esotropia and exotropua (r = 0.85, p < 0.001 and r = 0.8, p < 0.001, respectively). In children with “inappropriate” refraction (myopic with esotropia and hypermetropic — with exotropia), BVI was easier to occur and better maintained under hypocorrection by an average of 1.75 ± 0.06 d. In the control group of children, the maximum visual acuity under the control of BVI was observed with the strength of correcting lenses 0.5 D less compared to monocular conditions of the study.Conclusion. The effectiveness of using hypercorrection in children with non-paralytic strabismus and “appropriate” refraction for the formation of BVI on a binarimeter is shown. In this case, the value of hypercorrection has a direct dependence on the value of deviation, which is consistent with the principles of accommodation-convergent synkinesia. In children with non-paralytic strabismus and “inappropriate” refraction, more favorable conditions for the formation of BVI are created when using hypocorrection. The result of functional treatment on a binarimeter with an individual selection of optimal optics for performing exercises is an improvement of accommodation, binocular and stereo vision, an increase of fusion reserves and visual acuity.
Experimental in vitro Comparative Study of Chromovitectomy Agents Cyto- and Phototoxicity
Authors: Kislitsyna N. M. , Novikov S. V. , Perova N. V. , Kolesnik S. V. , Kolesnik A. I. , Veselkova M. P. 
Published: September 2020

Intravitreal use of vital dyes in combination with the action of endoillumination can induce a cyto- and phototoxic effect on posterior eye segment structures. The search for a staining agent with a maximum safety profile to retinal structures, intensively and selectively coloring vitreous body and vitreoretinal interface structure, remains relevant.Objective: to determine comparative viability of NIH / 3T3 mouse fibroblast cell culture with traditional agents for chromovitrectomy and “Vitreocontrast” suspension with and without endovitreal illumination.Materials and methods. NIH / 3T3 mouse fibroblast cultures contacted with agents for chromovitrectomy (MembraneBlue® Dual, Triamcinolone acetonide, “Vitreocontrast” suspension) and the corresponding controls in a volume of 50 μl / well. The test plate was irradiated with a Photon II illuminator (Synergetics, USA), working distance of 5 mm. The control tablet with the introduced preparations was not exposed to light. Next, the cells were washed and incubated, after which the morphology and lysis of the cells, as well as the number of proliferating relatively negative control of fibroblasts, were evaluated using the vital dye PrestoBlue Cell Viability Reagent. Negative control was the complete growth medium for the cultivation of mouse fibroblasts of the NIH / 3T3 line. The results of the cytotoxic reaction of a culture of mouse fibroblasts of the NIH / 3T3 line were interpreted using the table “The degree of cell response”.Results. Studies have shown that exposure to a source of endovitual illumination does not affect the cytotoxic effect of TA suspension and MembraneBlue® Dual dye. The TA suspension, both after light source and without it, has a moderate cytotoxic effect, and MembraneBlue® Dual has no cytotoxic effect on the culture of mouse fibroblasts of the NIH / 3T3 strain. Without light, “Vitreocontrast” suspension does not have cytotoxic effect on mouse fibroblasts culture NIH / 3T3 line. Light irradiation for 1 h increases the cytotoxicity of “Vitreocontrast” suspension to the level of unsharp cytotoxicity allowed by ISO Standard 10993-5-2011.Conclusion. The safety profile of MembraneBlue® Dual and “Vitreocontrast” suspension allows them to be recommended for use in endovitreal surgery. The cyto- and phototoxicity demonstrated in the experiment with TA suspension can reduce the functional outcomes of retinal surgery.
Experience with laparoscopic common bile duct exploration in failed endoscopic retrograde cholangiopancreatography cases at a tertiary care hospital
Authors: Panwar Pradeep , Reddy Hetish M. , Bagree Rajendra , Jalendra Gaurav 
Published: September 2020

Background: Minimally invasive techniques for stone removal in common bile duct (CBD) are endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy (LC) or laparoscopic CBD exploration with LC (laparoscopic common bile duct exploration (LCBDE) and LC). Failed, multiple attempted or complications of ERCP leads to other surgical approaches where LCBDE is a preferable option by experts due to its added benefits.Methods: We did LCBDE and LC in 40 cases of failed ERCP. Standard investigation protocol was followed in all cases and CBD were explored laparoscopically and stones were retrieved. Post retrieval choledochoscopy was done and sphincter of oddi was dilated by the dilators.Results: With careful selection of cases, stone calculi were retrieved successfully in 38 cases by laparoscopically and 2 cases by open method after conversion. Postoperative choledochoscopy were found normal. Bile leak seen in 3 cases, which were managed conservatively. Standard regime of postoperative care was taken followed by T-tube removal after cholangiogram on day 10-14. All patients survived the operation.Conclusion: We advocate that LCBDE is the most viable alternative for open surgery in failed ERCP cases for retrieval of CBD stones. This results in early recovery, better cosmetic scar, least complications with early resumption of routine life. Needs cautious patient selection and expertise in laparoscopic surgery.
The noninvasive assessment of maxillary sinus
Authors: Munjal Manish , Gupta Ritu , Rishi Porshia , Goyal Ajay , Munjal Shubham , Garg Shubham , Singh Archit Pal 
Published: September 2020

<p class="abstract">The maxillary sinus with its antigravity drainage affected by pathology at the osteomeatal unit, necessitates an intervention, medical or surgical. Role of basic imaging in pretreatment evaluation is elaborated upon. </p><p class="abstract"> </p>
Actividad Antioxidante y Antiproliferativa de Seis Plantas Medicinales del Noroeste de México
Authors: Vidal Gutiérrez Max , Torres Moreno Heriberto , Velázquez Contreras Carlos Arturo , Rascón Valenzuela Luisa Alondra , Robles Zepeda Ramón Enrique 
Published: September 2020

Las especies reactivas de oxígeno, que inducen estrés oxidativo en el organismo, son uno de los factores de riesgo para padecer de algún tipo de cáncer. En México los tipos de cáncer con mayor mortalidad son el de próstata, mama, cervicouterino, pulmón e hígado. Los productos naturales representan la forma más antigua de remedios medicinales, para el cáncer esta fuente no es una excepción. En esta investigación, se estudió la actividad antioxidante por ABTS y DPPH, y la actividad antiproliferativa de seis plantas medicinales del noroeste de México. Las cáscaras del fruto de Jacquinia macrocarpa ssp pungens mostraron la mejor actividad antiproliferativa del estudio con una IC50 de 9.2 mg/mL en A549, seguido por B microphylla con IC50 de 13.8 mg/mL en HeLa. Bursera laxiflora obtuvo la mejor actividad antioxidante de las seis plantas frente a los radicales ABTS y DPPH, así como también presentó actividad antiproliferativa en HeLa. La corteza de B. laxiflora contiene compuestos con actividad antioxidante, que probablemente, también sean los mismos que inducen la actividad antiproliferativa en células cancerosas. Por otro lado, J. macrocarpa y B. microphylla no presentan actividad antioxidante, sin embargo, las tres especies vegetales representan una fuente potencial de moléculas con actividad antiproliferativa.
Efectos de heterosis en poblaciones nativas de maíz y sus cruzas F1
Authors: Cervantes Adame Yessica Flor , Rebolloza Hernádez Hermes , Broa Rojas Elizabeth , Olvera Velona Angeluz , Bahena Delgado Gregorio 
Published: September 2020

RESUMEN
Con el objetivo de cuantificar la Heterosis Panmíctica (Hp) y determinar los efectos de Heterosis Varietal (Vj) y Heterosis especifica (sjj´), se utilizaron siete poblaciones de maíz nativo y sus 21 cruzas directas. Los 28 genotipos de maíz se evaluaron en tres ambientes del estado de Morelos (Ayala-O/I-2012/2013, Ayala-P/V-2013 y Tepalcingo-P/V-2013). El diseño experimental fue bloques completos al azar con tres repeticiones. Se midieron cuatro variables y se sometieron a un análisis de varianza combinado, comparación de medias (DMS0.01), la Hp se calculo de manera porcentual, la Heterosis varietal y Heterosis específica se determinaron por el método de Gardner y Eberhart. En la expresión porcentual la Cruza-17 presentó valores positivos en Hp en las variables de GM (19.16), HM (11.81), P100G (7.77) y RG (5.36). En la (Vj´) los progenitores con mayor efecto fueron BCP1 (5) y CB029 (6), ambos impactaron en la formación de cruzas con los valores más altos de (sjj´) como la Cruza-26 y Cruza-56 esto para RG y GM. Lo anterior permite la selección de poblaciones nativas de maíz para mejorar características relacionadas al rendimiento de grano mediante el cruzamiento inter-poblacional.
Palabras clave:efecto varietal, cruzas, rendimiento
La junta central de higiene de Colombia, otra de las víctimas de la pandemia de gripa de 1918-1919
Authors: Martínez Martín Abel Fernando , Meléndez Álvarez Bernando Francisco , Manrique Corredor Edwar Javier 
Published: September 2020

Objetivo: El presente artículo, a través de las fuentes primarias, busca establecer el papel del Estado y las medidas tomadas ante la aparición de la pandemia de gripa de 1918 en Bogotá. Materiales y métodos: Se consultaron como fuentes primarias los periódicos que circulaban en Bogotá y Colombia durante 1918, los informes oficiales de la Junta Central de Higiene y de la Junta de Socorros y las tesis de medicina de la Universidad Nacional de Colombia, además de hacer una revisión de las fuentes secundarias sobre el tema. Conclusión: La Higiene Pública, en manos del Estado, se mostró incapaz de hacer frente a la pandemia, siendo la Junta de Socorros, un organismo privado constituido por los notables de la capital, la única institución que realizó acciones efectivas con los afectados. Esta institución aparece recordada y alabada porlos medios escritos, en contraposición a la Dirección Nacional y Municipal de Higiene, que fueron fuertemente criticadas por su escasa intervención ante la pandemia y representadas como víctimas en las caricaturas.
Dunia dan Dīn (Agama) di Tengah Arus Globalisasi
Authors: Hidayat Rahmat 
Published: September 2020

Globalisasi sebagai sebuah proses atau keharusan sejarahmampu mempengaruhi segala lini kehidupan manusia. Perkembangannya yang begitu pesat mesti disikapi secara proporsional, terlebih bagi umat Islam yang memiliki tatanan ajaran global, yang tetap relevan seiring dengan berkembangnya zaman. Globalisasi yang berlangsung dewasa ini cenderung kapada urusan duniawi yang sarat dengan unsur-unsur modernitas, yang dampaknya dapat dirasakan tidak hanya dilihatdari aspek ekonomi, sains dan teknologi sajamelainkan aspek-aspek lainnya seperti budaya, fun, fashion, sosial, gaya hidup (life style), pendidikan, politik, pemikiran dan Agama.Tulisan ini bertujuan untuk memetakan di mana wilayah globalisasi, apakah ke ranah dunia atau Agama dan bagaimana dampak globalisasi Agama?

Kata Kunci: globalisasi, dunia, agama