bluuebunny/crossref_metadata_2025_split huggingface dataset:
An analysis of infections incidence of multiple human papillomavirus (HPV) rising in cervical and genital samples
Authors: Hu Wen , Liu Xin-mei , Guan Meng-meng , Zhang De-zhi , Kang Xiao-jing 
Published: December 2019

Abstract
Background : Human papillomavirus (HPV) is associated with cervical cancer and genital condyloma, which is mainly transmitted through sexual contact.Cervical HPV infection in females and genital HPV infection in males can induce epithelial proliferation on both mucosal and cutaneous surfaces. HPV is divided into high-risk (HR) and low-risk (LR) types according to their oncogenic potential. The HR geneotypes are considered as etiological factors for invasive cervical cancer in females, and the LR geneotypes are correlated with hyperplastic lesions, including external genital warts, condyloma acuminata, and so on. The aim of this study was to investigate the prevalence of HPV infection and geneotype distribution among individuals in Xinjiang Province.Methods A total of 1094 patients the etiology and species with characteristic of cervical and genital warty surface which mainly come from CA in dermatology and STD outpatient service of People's Hospital of Xinjiang Uygur Autonomous Region.Using a method of real-time fluorescence quantitative PCR for the detection of human papilloma virus HPV 23 typing.Results The prevalence of HPV infection was 67.46%, the most common LR-HPV subtypes were HPV-6 (16.27%), HPV-11 (4.57%), HPV-42(1.19%) and HPV-43(1.19%), and HR-HPV subtypes were HPV-16 (1.65%) and HPV-58(0.91%). The prevalence of HPV infection with single subtype and multiple subtypes was 32.91% and 34.55%, respectively. Among the females infected with a single HPV subtype, 26.11% were infected with a HR-HPV subtype. Among the females infected with multiple HPV subtypes, 18.52% were infected with multiple HR-HR HPV subtypes. The prevalence and subtype distribution of HPV infection showedage differences ( P =0.012), and the prevalence peak of HPV infection was observed in females aged 20-29 years (292/404, 72.28%).Conclusion The prevalence of multiple infection was higher than singleinfection, and the prevalence varied significantly with age while had little association with race and gender.
Midbrain/pons area ratio and clinical features predict the prognosis of Progressive Supranuclear Palsy
Authors: cui shishuang , ling huawei , du juanjuan , lin yiqi , pan jing , zhou haiyan , wang gang , wang ying , xiao qin , liu jun , tan yuyan , chen shengdi 
Published: December 2019

Abstract
Introduction: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. The natural history of PSP has been described in a few studies. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living.Method: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, gender, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. K-M method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization.Results: 59 patients fulfilled MDS-PSP criteria were enrolled in our study. 19 patients (32.2%) had died and 31 patients (52.5%) had institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio.Conclusion: Older AAO and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.
Study on the purification effect of a pediatric isolation bed on the air in general hospital wards
Authors: Liu Tiantian , Wang Mei , Hao Xiaotang , Guo Yubing , Zhou Rong 
Published: December 2019

Abstract
Background: Patients with acute infectious respiratory illness may emit bio-aerosols containing pathogens capable of infecting susceptible hosts, including other patients and healthcare workers. This study aimed to evaluate the purification effect of a pediatric isolation bed on aerosols and microorganisms in the air in experiment rooms and verify the purification efficiency in general wards. Methods: Experiments were carried out in two settings: one with isolation bed and the other with regular bed. Using a dust particle counter to discriminate particles sizes in the air and using Anderson’s six levels to discriminate S. albicans, the purification rate in the two rooms was evaluated. The concentration of cigarette particles(size 0.3–0.5 μm,0.5-1.0μm ) and S. albicans in the air was significantly decreased in the experimental room, indicating that the air was purified. Then detection the aerosol in the room to vilidaty the purification rate.Finally detection of aerosol and sedimentation bacteria in the air of general wards. Results: Isolation beds in demonstration ward have a purifying effect on both aerosols and sedimentation bacteria. Conclusions:Isolation bed can therefore be used in hospitals to reduce the risk of nosocomial infection and protect the health of doctors, patients, and visiting relatives.
Umbilical cord blood vitamin A levels in relation to the outcome of late-preterm infant: A prospective study
Authors: Tao En-Fu , Chen Cai-E , Chen Yun-Qin , Cai Lin-Yan , Yuan Tian-Ming 
Published: December 2019

Abstract
Background: Low Vitamin A levels of plasma increase the risk of neonates’ morbidity. However, whether umbilical cord blood (UCB) vitamin A levels have an association with the outcomes of late-preterm infants (LPI) is not well established. This study aimed to determine umbilical cord blood vitamin A levels and their correlation with outcomes of late-preterm infants. Methods: We prospectively studied 208 LPI between January 1, 2014，and June 30, 2015. The specimens of UCB were collected shortly after birth, and vitamin A levels were determined by Enzyme-Linked Immunosorbent Assay. All singleton newborns, with 34+0 weeks to 36+6 weeks’ gestational age, were eligible for study inclusion in the studied time intervals. Exclusion criteria included significant congenital malformations or chromosomal abnormality or congenital metabolic disease, or life-threatening disease. All subjects were implemented to follow up, and jaundice, sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, death, etc. were recorded. Results: The prevalence of low UCB vitamin A level <0.7 μmol/L was 37.5% in LPI. UCB vitamin A levels of LPI with cesarean section was lower than that with vaginal delivery (0.734 (0.634-0.796) μmol/L VS 0.904 (0.666-1.100) μmol/L P = 0.001). Additionally, binary logistic regression analysis revealed that the cesarean section was an independent risk factor for UCB vitamin A level < 0.7 μmol/L. However, UCB vitamin A levels did not correlate with gestational age, birth weight, and sex. Neonates with hospitalization or oxygen supplementation or RDS group had significantly lower UCB vitamin A levels than their counterparties ( P < 0.05), other than with hyperbilirubinemia or sepsis ( P > 0.05). However, univariate binary logistics regression analysis suggested that UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen therapy, hyperbilirubinemia, sepsis and RDS. Conclusions: Low umbilical cord blood vitamin A levels are common among late-preterm infants. Delivery with cesarean section is an independent risk factor for low umbilical cord blood vitamin A level. However, there is no evidence that low vitamin A level is associated with morbidity of late-preterm infants, including hyperbilirubinemia, sepsis and respiratory distress syndrome.
Health-related quality of life (FACT-GP) in Sweden
Authors: Bagge Ann-Sophie Lindqvist , Carlander Anders , Fahlke Claudia , Bagge Roger Olofsson 
Published: December 2019

Abstract
Background: Though many studies have used disease-specific instruments, such as the Functional Assessment of Cancer Therapy (FACT), when studying health-related quality of life (HRQOL) in patients, few studies have described normative HRQOL values in the general population using FACT - General Population (FACT-GP). The general aim of the present study is to describe the normative HRQOL values in the general Swedish population by using the FACT-GP instrument and investigate to what degree sociodemographic factors and status of self-rated health (SRH) correlates with HRQOL. Methods: The participants consisted of a pre-stratified (gender, age and education) sample of Swedish citizens that previously had enrolled to be a part of a web panel hosted by a research institute (SOM Institute) at the University of Gothenburg in Sweden. The HRQOL was assessed by using the FACT-GP and self-rated health status (SRH). Results: A higher FACT-GP score was mainly associated with males, higher age, higher income and better SRH. The results showed that the Swedish sample scored lower on FACT-GP than previous studies. Conclusions: Since HRQOL is frequently used as an important endpoint in healthcare research, there is an increasing need for normative data. The results from this study serve as a general population standard to which other studied HRQOL-data could be given meaning.
Interpretation and content validity of the items of the numeric rating version Short-WORC to evaluate outcomes in management of rotator cuff pathology: A cognitive interview approach.
Authors: Furtado Rochelle , MacDermid Joy C , Bryant Dianne , Faber Kenneth J , Athwal George S 
Published: December 2019

Abstract
Background: The shortened version of the Western Ontario Rotator Cuff Index (Short-WORC) is a patient reported outcome measure that evaluates quality of life (QoL) of patients with rotator cuff pathology. However, formal content validation of the full or Short-WORC has not been reported. This study aims to understand how 1) people interpret and calibrate responses to items on the Short-WORC and 2) compensatory strategies that might enhance function and thereby affect responses.

Methods: This study uses cognitive interviewing, a qualitative methodology that focuses on the interpretation of questionnaire items. Patients with rotator cuff disorders (n=10), clinicians (n=6) and measurement researchers (n=10) were interviewed using a talk aloud structured interview that evaluated each of the 7 items of the Short-WORC. All interviews were recorded and transcribed verbatim by one researcher (R.F). Analysis was done through an open coding scheme using a previously established framework.

Results: Overall, the items on the Short-WORC were well received by participants. Through the interviews, the 6 themes of: Comprehension, Inadequate response definition, Reference Point, Relevance, Perspective Modifiers and Calibration Across Items emerged. The items of working above the shoulder (90%), compensating with the unaffected arm (88%) and lifting heavy objects (92%) were the most relevant to participants. Participants calibrated their scores on the items of sleeping and styling (19%) the most. Perspective modifiers of gender, influenced the calibrations of items of styling your hair (30%) and dressing or undressing (19%). Compensatory strategies of task-re allocation and using assistive devices/resources were frequently mentioned by participants. Overall, participants had minor comprehension issues, but found the 7- items of the Short-WORC to be relevant to QoL.

Conclusions: Therefore, the findings demonstrate that the Short-WORC is not cognitively complex, but varies with patient perspectives. Overall, the Short-WORC provides evidence of demonstrating strong content validity when used for rotator cuff disorder patients.
Measurement properties of the Musculoskeletal Health Questionnaire (MSK-HQ): a between country comparison
Authors: Christiansen David Høyrup , McCray Gareth , Winding Trine Nøhr , Andersen Johan Hviid , Nielsen Kent Jacob , Karstens Sven , Hill Jonathan C 
Published: December 2019

Abstract
Background The Musculoskeletal Health Questionnaire (MSK-HQ) has been developed to measure musculoskeletal health status across musculoskeletal conditions and settings. However, the MSK-HQ needs to be further evaluated across settings and different languages. Objective The objective of the study was to evaluate and compare measurement properties of the MSK-HQ across Danish (DK) and English (UK) cohorts of patients from primary care physiotherapy services with musculoskeletal pain. Methods MSK-HQ was translated into Danish according to international guidelines. Measurement invariance was assessed by differential item functioning (DIF) analyses. Test-retest reliability, measurement error, responsiveness and minimal clinically important change (MCIC) were evaluated and compared between DK (n=153) and UK (n=166) cohorts. Results The Danish version demonstrated acceptable face and construct validity. Out of the 14 MSK-HQ items, three items showed DIF for language (pain/stiffness at night, understanding condition and confidence in managing symptoms) and three items showed DIF for pain location (walking, washing/dressing and physical activity levels). Intraclass Correlation Coefficients for test-retest were 0.86 (95% CI 0.81 to 0.91) for DK cohort and 0.77 (95% CI 0.49 to 0.90) for the UK cohort. The systematic measurement error was 1.6 and 3.9 points for the DK and UK cohorts respectively, with random measurement error being 8.6 and 9.9 points. Receiver operating characteristic (ROC) curves of the change scores against patients’ own judgment at 3 months exceeded 0.70 in both cohorts. Absolute and relative MCIC estimates were 8-10 points and 26% for the DK cohort and 6-8 points and 29% for the UK cohort. Conclusions The measurement properties of MSK-HQ were acceptable across countries, but seem more suited for group than individual level evaluation. Researchers and clinicians should be aware that some discrepancy exits and should take the observed measurement error into account when evaluating change in scores over time.
Impact of Surgeon Handedness in Manual and Robot-assisted Total Hip Arthroplasty
Authors: Kong Xiangpeng , Yang Minzhi , Li Xiang , Ni Ming , Zhang Guoqiang , Chen Jiying , Wei Chai 
Published: December 2019

Abstract
Background The purpose of this study was to examine whether surgeon handedness could affect cup positioning in manual total hip arthroplasty (THA), and whether robot could diminish or eliminate the impact of surgeon handedness on cup positioning in robot-assisted THA.Methods Fifty-three patients who underwent bilateral robot-assisted THA and sixty-two patients who underwent bilateral manual THA between August 2018 and July 2019 in our institute were respectively analyzed in this study. When the difference between the bilateral anteversion or inclination was greater than 5°, the patient was regarded as having different cup positioning between bilateral THA. Their demographics, orientation of acetabular cup and postoperative 3 month Harris hip score (HHS) were recorded for analysis.Results There were no significant difference in the gender, age, BMI, diagnosis's composition, preoperative and postoperative HHS between the robotic and manual group. Two left hips dislocated in the manual group. The anteversion of left hip was significantly larger than that of right hip (24.77±10.44 vs 22.44±8.67, p=0.043) in the manual group. There were no significant difference of cup positioning between bilateral robot-assisted THA. The patients in manual group were significantly more likely to have different cup positioning between bilateral hips than those in robotic group (77% vs 45%, p=0.000).Conclusions Surgeon's handedness had adverse impact on anteversion of the non-dominant side in manual THA and right-handed surgeons were more likely to place the left cup in larger anteversion. Robot could help surgeon eliminate the adverse impact caused by personal innate handedness.
The impact of ultrasonography on quality of cardiopulmonary resuscitation: a retrospective observational study
Authors: Lien Wan-Ching , Chong Kah-Meng , Chang Herman Chih-Heng , Cheng Su-Fen , Chang Wei-Tien , Huei-Ming Matthew , Chen Wen-Jone 
Published: December 2019

Abstract
Background: This study aims to evaluate the effect of ultrasonography (US) on quality of cardiopulmonary resuscitation (CPR), and US-related pause duration of pulse-checks.Methods: This retrospective observational study was conducted at the emergency department of National Taiwan University Hospital between April 2017 and May 2018. Video recordings for adult patients with non-traumatic cardiac arrest in designated resuscitation rooms were collected. The primary outcome was chest compression fraction (CCF) in the CPR with US group. The secondary outcome was pause duration of pulse checks with introduction of US or not. US-related pulse-checks were stratified into US during hands-off periods only (hands-off US), and US performing from hands-off to hands-on periods (continuous US). Results: A total of 153 patients were enrolled. Continuous US was performed in 116 patients. CCF was similar (92%) between the CPR with and without US groups. In the CPR with US group, pause duration was significantly longer in US-related pulse-checks than that without US (9.3±8.0 v.s. 7.3±4.7s, p<0.0001). Notably, longer pause was noted in the hands-off US, as comparing with that in the continuous US (18.3±16.4 v.s. 7.7±3.5s, p<0.0001). Conclusions: The introduction of US during CPR did not impact on CCF. Individual pause would not be lengthened if continuous US was performed while allowing chest compressions to be resumed. In addition, structured training, adequate facilities and manpower, and a timer reminding resumption of chest compressions would help sophisticated integration of US into CPR process.
Capturing the complexity of healthcare for people with Down syndrome in quality indicators - a Delphi study involving healthcare professionals and patient organisations
Authors: Mareeuw Francine A. van den Driessen , Coppus Antonia M.W. , Delnoij Diana M.J. , de Vries Esther 
Published: December 2019

Abstract
Background Insight into quality of healthcare for people with Down Syndrome (DS) is limited. Quality indicators (QIs) can provide this insight. This study aims to find consensus among participants regarding QIs for healthcare for people with DS.Methods We conducted a four-round Delphi study, in which 33 healthcare professionals involved in healthcare for people with DS and two patient organisations’ representatives in the Netherlands participated. Median and 75-percentiles were used to determine consensus among the answers on 5-point Likert-scales. In each round, participants received an overview of participants’ answers from the previous round.Results Participants agreed (consensus was achieved) that a QI-set should provide insight into available healthcare, enable healthcare improvements, and cover a large diversity of quality domains and healthcare disciplines. However, the number of QIs in the set should be limited in order to prevent registration burden. Participants were concerned that QIs would make quality information about individual healthcare professionals publicly available, which would induce judgement of healthcare professionals and harm quality, instead of improving it.Conclusions We unravelled the complexity of capturing healthcare for people with DS in a QI-set. Patients’ rights to relevant information have to be carefully balanced against providers’ entitlement to a safe environment in which they can learn and improve. A QI-set should be tailored to different healthcare disciplines and information systems, and measurement instruments should be suitable for collecting information from people with DS. Results from this study and two preceding studies, will form the basis for the further development of a QI-set.
Oligotrophic bacterium Hymenobacter latericoloratus CGMCC 16346 degrades the neonicotinoid imidacloprid in surface water
Authors: Guo Leilei , Dai Zhiling , Guo Jingjing , Yang Wenlong , Ge Feng , Dai Yijun 
Published: December 2019

Abstract
The intensive and extensive application of imidacloprid in agriculture has resulted in water pollution and risks to aquatic invertebrates. However, pure bacteria remediation of imidacloprid in surface water environments has not been studied. Here, we isolated an imidacloprid-degrading bacterium from a water environment, examined its imidacloprid degradation in pure culture and surface water, sequenced its genome, and compared its Clusters of Orthologous Groups (COG) protein categorization with that for another imidacloprid-degrading bacterium. The isolate was an obligate oligotrophic bacterium, Hymenobacter latericoloratus CGMCC 16346, which degraded imidacloprid via hydroxylation by co-metabolism in pure culture. Resting cells degraded 64.4% of 100 mg/L imidacloprid in 6 d in the presence of co-substrate maltose, and growing culture degraded 40.8% of imidacloprid in 10 d. H. latericoloratus CGMCC 16346 degraded imidacloprid in surface water without co-substrate supplementation and retained imidacloprid-degrading activity after 30 d. The half-life of imidacloprid in surface water was decreased from 173.3 d in the control to 57.8 d by CGMCC 16346 inoculation. Genome sequencing and COG analysis indicated that carbohydrate metabolism and transport, cell wall/membrane biogenesis, and defense mechanisms are enriched in H. latericoloratus CGMCC 16346 compared with the copiotrophic imidacloprid-degrading Pseudoxanthomonas indica CGMCC 6648, indicating that H. latericoloratus CGMCC 16346 is adapted to live in oligotrophic water environments and biofilms. H. latericoloratus CGMCC 16346 is a promising bioremediation agent for elimination of imidacloprid contamination from surface water.