bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese biomedical preparation (Huaier Granule) for breast cancer: a PRISMA-compliant meta-analysis
Authors: Yao Xialei , Wu Wenwen , Qu Kai , Xi Wei 
Published: August 2020

AbstractHuaier Granule, a type of traditional Chinese biomedical preparation (TCBP), is considered to be a promising adjuvant therapy for breast cancer. Although an analysis of the published literature has been performed, the exact effects and safety of Huaier Granule remains controversial. Therefore, a wide-ranging systematic search of electronic databases from which to draw conclusions was performed. Data from 27 trials, including 2562 patients with breast cancer were analyzed. The results indicated that, compared with conventional treatment alone, the combination of conventional treatment and Huaier Granule markedly improved patients’ overall response (P=0.02) and quality of life (P&lt;0.00001), and significantly prolonged 2-year (P=0.02), 3-year (P&lt;0.0001) and 5-year (P=0.004) overall survival rates, and 1-year (P=0.003), 2-year (P&lt;0.00001), 3-year (P&lt;0.00001) and 5-year (P=0.03) disease-free survival. The immune function of patients was also significantly enhanced after combined intervention treatment, indicated by clearly increased percentages of CD3+ (P=0.05), CD4+ (P&lt;0.00001) and natural killer cells (P&lt;0.0001), and CD4+/CD8+ ratio (P&lt;0.00001). The incidence of myelosuppression (P=0.001) and hepatotoxicity (P=0.05) was lower in breast cancer patients treated with Huaier Granule, whereas other adverse events did not differ significantly between the two groups (P&gt;0.05). In summary, results of this meta-analysis suggest that the combination of conventional treatment and Huaier Granule is more effective for the treatment of breast cancer than conventional treatment alone.
Governing games Adaptive game selection in the Math Garden
Authors: Brinkhuis Matthieu , Cordes Wessel , Hofman Abe 
Published: August 2020

Utilizing online digital educational content has become the norm when teaching young students. A variety of adaptive educational practice sys- tems is readily available and allows students to practice various domains, on a preferred difficulty and pace. However, due to the intensification of the teaching profession and the possibilities of practicing from home, students might be left unsupervised, and as a result do not practice domains that are most important. This study proposes a solution to govern these students, i.e., provide comput- erized data driven supervision that guides students in practicing domains most important with no intervention of a teacher.
Through an experiment involving 13 578 participants, a new governing method was tested and found to have positive effects on both engagement and learning, with almost no changes to the visual interface needed. Governing seems a promising technique in general, and was effectively tested and introduced in Math Garden.
Aktuelle Übersicht: multifokale Linsen und Extended-Depth-of-Focus-Intraokularlinsen
Authors: Breyer Detlev R. H. , Beckers Lena , Ax Timon , Kaymak Hakan , Klabe Karsten , Kretz Florian Tobias Alwin 
Published: August 2020

ZusammenfassungDas Bedürfnis von Presbyopie- und Kataraktpatienten nach einer erhöhten postoperativen Brillenunabhängigkeit ist einer der Hauptgründe für die Entwicklung multifokaler Intraokularlinsen (MIOL) und erweiterter Tiefenschärfe (EDOF) bei intraokularen Linsen (IOL). Da sich in den letzten 10 Jahren die Bereiche Ausbildung, Biometrie, Diagnostik, chirurgische Techniken und MIOL-/EDOF-IOL-Designs verbessert haben, sind immer mehr Kataraktchirurgen zu Katarakt- und Refraktivchirurgen geworden, um diesen Anforderungen gerecht zu werden. Es gibt jedoch keine einzige MIOL/EDOF-IOL, die für alle Patienten geeignet ist. Die große Vielfalt an MIOL und EDOF-IOL, ihrer Optiken und ihr jeweiliger Einfluss auf die Sehqualität unserer Patienten müssen verstanden werden, um die geeignete IOL für jedes Individuum passend auszuwählen. MIOL-/EDOF-IOL-Chirurgie muss individuell geplant werden. Dieser Review untersucht die verschiedenen optischen Aspekte und klinischen Konsequenzen von
MIOL/EDOF-IOL, um Chirurgen bei der Suche nach geeigneten Lösungen für jeden einzelnen Patienten zu unterstützen.
US-Guided Percutaneous Radiofrequency Ablation of Locally Advanced Pancreatic Adenocarcinoma: A 5-Year High-Volume Center Experience
Authors: D’Onofrio Mirko , Beleù Alessandro , Sarno Alessandro , De Robertis Riccardo , Paiella Salvatore , Viviani Elena , Frigerio Isabella , Girelli Roberto , Salvia Roberto , Bassi Claudio 
Published: August 2020

Abstract
Purpose The aim of this study was to investigate the safety and effectiveness of percutaneous radiofrequency ablation (RFA) in locally advanced pancreatic cancer (LAPC) of the pancreatic body by assessing the overall survival of patients and evaluating the effects of the procedure in the clinical and radiological follow-up.
Materials and Methods Patients with unresectable LAPC after failed chemoradiotherapy for at least six months were retrospectively included. Percutaneous RFA was performed after a preliminary ultrasound (US) feasibility evaluation. Contrast-enhanced computed tomography (CT) and CA 19.9 sampling were performed before and 24 hours and 30 days after the procedure to evaluate the effects of the ablation. Patients were followed-up after discharge considering the two main endpoints: procedure-related complications and death.
Results 35 patients were included, 5 were excluded. All patients underwent RFA with no procedure-related complications reported. The mean size of tumors was 49 mm before treatment. The mean dimension of the ablated necrotic zone was 32 mm, with a mean extension of 65 % compared to the whole tumor size. Tumor density was statistically reduced one day after the procedure (p < 0.001). The mean CA 19.9 levels before and 24 hours and 30 days after the procedure were 285.8 U/mL, 635.2 U/mL, and 336.0 U/mL, respectively, with a decrease or stability at the 30-day evaluation in 80 % of cases. The mean survival was 310 (65–718) days.
Conclusion Percutaneous RFA of LAPC is a feasible technique in patients who cannot undergo surgery, with great debulking effects and a very low complication rate.
Konsenserfahrung von International Uveitis Study Group, Intraocular Inflammation Society und Foster Ocular Inflammation Society zur Uveitis in der Zeit der COVID-19-Infektion
Authors: Zierhut Manfred , de Marc D.Smet , Gupta Vishali , Pavesio Carlos , Nguyen Quan Dong , Chee Soon-Phaik , Agarwal Rupesh 
Published: August 2020

ZusammenfassungDieses Dokument fasst die Erfahrungen der International Uveitis Study Group (IUSG), der Intraocular Inflammation Society (IOIS) und der Foster Ocular Inflammation Society (FOIS) zusammen und kann als Leitfaden für die Behandlung von Uveitispatienten im Zeitalter der COVID-19-Pandemie dienen.
Pregnancy Outcomes Following Letrozole Use in Frozen-thawed Embryo Transfer Cycles: A Systematic Review and Meta-analysis
Authors: Chen Dongjia , Shen Xiaoting , Fu Yu , Ding Chenhui , Zhong Yiping , Zhou Canquan 
Published: August 2020

AbstractWhile widely used for ovulation induction in assisted reproductive technology, the clinical efficacy of letrozole for endometrial preparation prior to frozen-thawed embryo transfer (FET) cycles remains yet to be elucidated. We performed a meta-analysis to compare pregnancy outcomes after letrozole use with those of other endometrial preparation protocols in patients undergoing FET. PubMed, Scopus, Embase and the Cochrane Library were searched for eligible studies. Clinical pregnancy rate (CPR), live birth rate (LBR) and birth defect rate (BDR) were analysed using odds ratio (OR) and 95% confidence interval (CI). A total of 10 studies representing 75 968 FET cycles were included. Comparable CPR and LBR were observed when comparing letrozole administration with natural cycle (OR 1.24, 95% CI: 0.69 – 2.24; OR 1.18, 95% CI: 0.60 – 2.32), artificial cycle (OR 1.46, 95% CI: 0.87 – 2.44; OR 1.39, 95% CI: 0.77 – 2.52), and artificial cycle with gonadotropin-releasing hormone agonist suppression (OR 1.11, 95% CI: 0.78 – 1.59; OR 1.18, 95% CI: 0.82 – 1.68). Pooled results of the limited studies comparing letrozole with human menopausal gonadotropin demonstrated a similar CPR between groups (OR 1.46, 95% CI: 0.29 – 7.21, two studies), but the letrozole group had a statistically lower LBR (OR 0.67, 95% CI: 0.52 – 0.86, one study). No increased BDR was observed in the letrozole group compared to natural cycles or artificial cycles (OR 0.98, 95% CI: 0.60 – 1.61; OR 1.39, 95% CI; 0.84 – 2.28). This pooled analysis supports the use of letrozole as an efficacious and safe alternative to mainstream regimens for endometrial preparation in FET cycles.
Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women
Authors: Kühle Anna-Maria , Wacker Jürgen 
Published: August 2020

AbstractObjective The aim of this study was to determine the present oral health status of pregnant women depending on selected sociodemographic differences and deduce any resulting consequences for health prevention.Methods The participantsʼ data of relevance to the study such as age, school leaving qualification, migration background, smoking habits or last dentist visit were recorded using a questionnaire. The subsequent dental check-up concentrated on open carious lesions, any initiated root canal treatments and missing teeth. Finally, the Periodontal Screening Index was recorded to diagnose the presence of any gingivitis or periodontitis. The subsequent biometric evaluation comprised descriptive data analysis, χ2 test and logistical regression.Results The higher the school leaving qualification, the lower the probability that a pregnant woman smoked prior to pregnancy (OR 0.291; 95% CI 0.114 – 0.743) and that tartar was diagnosed (OR 0.424; 95% CI 0.185 – 0.973). Regular dentist visits (OR 4.026; 95% CI 1.613 – 10.049) increase with the attained school leaving qualification. There is a greater chance that women born in Germany taking part in the study were aware of dental risks in pregnancy (OR 2.652; 95% CI 1.285 – 5.472) and attended the dentist during pregnancy (OR 2.507; 95% CI 1.281 – 4.907).Conclusion The rate of awareness of the risks and consequences of pregnancy for oral health must be increased. The main aim for primary prophylaxis should be a reduction in the periodontal bacteria and caries of the mother and father.
COVID-19 During Pregnancy and Puerperium – A Review by the Austrian Society of Gynaecology and Obstetrics (OEGGG)
Authors: Klaritsch Philipp , Ciresa-König Alexandra , Pristauz-Telsnigg Gunda ,   on behalf of the board of the OEGGG
Published: August 2020

AbstractAfter the first case of COVID-19 pneumonia was reported in Wuhan, Hubei Province, China, in December 2019, the infection quickly spread to the rest of China and then to the wider world. The available information on pregnant women infected with COVID-19 is now significantly greater. There are now several case series and systematic reviews of cohorts, some of which include more than 100 cases. This review evaluates the scientific literature available until May 1, 2020 and discusses common questions about COVID-19 in the context of pregnancy and the postpartum period.
Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement – Update 2020
Authors: Paspatis Gregorios A. , Arvanitakis Marianna , Dumonceau Jean-Marc , Barthet Marc , Saunders Brian , Turino Stine Ydegaard , Dhillon Angad , Fragaki Maria , Gonzalez Jean-Michel , Repici Alessandro , van Wanrooij Roy L.J. , van Hooft Jeanin E. 
Published: August 2020

Summary of Recommendations1 ESGE recommends that each center implements a written policy regarding the management of iatrogenic perforations, including the definition of procedures that carry a higher risk of this complication. This policy should be shared with the radiologists and surgeons at each center.2 ESGE recommends that in the case of an endoscopically identified perforation, the endoscopist reports its size and location, with an image, and statement of the endoscopic treatment that has been applied.3 ESGE recommends that symptoms or signs suggestive of iatrogenic perforation after an endoscopic procedure should be rapidly and carefully evaluated and documented with a computed tomography (CT) scan.4 ESGE recommends that endoscopic closure should be considered depending on the type of the iatrogenic perforation, its size, and the endoscopist expertise available at the center. Switch to carbon dioxide (CO2) endoscopic insufflation, diversion of digestive luminal content, and decompression of tension pneumoperitoneum or pneumothorax should also be performed.5 ESGE recommends that after endoscopic closure of an iatrogenic perforation, further management should be based on the estimated success of the endoscopic closure and on the general clinical condition of the patient. In the case of no or failed endoscopic closure of an iatrogenic perforation, and in patients whose clinical condition is deteriorating, hospitalization and surgical consultation are recommended.
Endovascular Management of Pancreatitis-Related Hemorrhage: Single-Center Experience
Authors: Kumar Sunil , Singh Jagadeesh R. , Kumar Mahesh T. , Nagbhushan K.N. , Reddy Nageshwar D. , Rao G.V. 
Published: August 2020

Abstract
Purpose The main purpose of this article is to assess the outcomes of endovascular management of pancreatitis-related hemorrhage.
Materials and Methods Retrospective analysis of patients referred for endovascular management of pancreatitis-related bleeding from January 2010 to December 2017 was performed. Patients’ demographics, clinical presentation, etiology, laboratory findings, angiography findings, details of the endovascular procedure, technical outcome, clinical outcome, and complications were assessed.
Results One hundred and five patients with a mean age of 37 years were included in this study. Splenic artery (41.7%) was the most commonly involved vessel. Middle colic, left colic, superior mesenteric, jejunal, left inferior phrenic, and left renal subcapsular arteries were the less commonly involved vessels. Embolization was performed using coils in 72 (68.5%) patients, n-butyl cyanoacrylate (n-BCA) in 21 (20%) patients, both coil and n-BCA in 8 (7.6%) patients, and 4 (3.8%) patients underwent stent graft placement. Technical success was achieved in 98% (n = 103) and clinical success in 93.2% (n = 96) of patients. Rebleeding was seen in 6.8% (n = 7) of patients. Six patients with rebleeding were managed by reintervention. Four patients had rebleeding from the same vessel, and two patients had rebleeding from a different vessel. One patient died due to massive rebleeding. Minor complications were seen in 14.2% (n = 15), major complications were seen in 3.8% (n = 4), and mortality rate was 0.9% (n = 1).
Conclusion Endovascular treatment is effective in the management of pancreatitis-related bleeding and is associated with low rebleeding rate and low mortality rate.
Evaluation of Predictive Models for Complications following Spinal Surgery
Authors: Dietz Nicholas , Sharma Mayur , Alhourani Ahmad , Ugiliweneza Beatrice , Wang Dengzhi , Drazin Doniel , Boakye Max 
Published: August 2020

Abstract
Background Complications rates vary across spinal surgery procedures and are difficult to predict due to heterogeneity in patient characteristics, surgical methods, and hospital volume. Incorporation of predictive models for complications may guide surgeon decision making and improve outcomes.
Methods We evaluate current independently validated predictive models for complications in spinal surgery with respect to study design and model generation, accuracy, reliability, and utility. We conducted our search using Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and the Participants, Intervention, Comparison, Outcomes, Study Design model through the PubMed and Ovid Medline databases.
Results A total of 18 articles met inclusion criteria including 30 validated predictive models of complications after adult spinal surgery. National registry databases were used in 12 studies. Validation cohorts were used in seven studies for verification; three studies used other methods including random sample bootstrapping techniques or cross-validation. Reported area under the curve (AUC) values ranged from 0.37 to 1.0. Studies described treatment for deformity, degenerative conditions, inclusive spinal surgery (neoplasm, trauma, infection, deformity, degenerative), and miscellaneous (disk herniation, spinal epidural abscess). The most commonly cited risk factors for complications included in predictive models included age, body mass index, diabetes, sex, and smoking. Those models in the deformity subset that included radiographic and anatomical grading features reported higher AUC values than those that included patient demographics or medical comorbidities alone.
Conclusions We identified a cohort of 30 validated predictive models of complications following spinal surgery for degenerative conditions, deformity, infection, and trauma. Accurate evidence-based predictive models may enhance shared decision making, improve rehabilitation, reduce adverse events, and inform best practices.
Anterior Clinoid Metastasis as First Presentation of a Signet Ring Cell Carcinoma: An Intriguing Diagnosis
Authors: d'Avella Elena , Guadagno Elia , Ugga Lorenzo , Solari Domenico , Cavallo Luigi Maria 
Published: August 2020

Abstract
Background We report an extremely unusual case of anterior clinoid process (ACP) metastasis as the first presentation of a signet ring cell carcinoma.
Case Description A 54-year-old female patient presented with right-sided visual disturbances due to optic nerve compression from a computed tomography (CT)-identified right anterior clinoid bone lesion. Contrast-enhanced magnetic resonance imaging showed an extra-axial, well-bordered enhancing mass extending from the right ACP toward the inner lumen of the optic canal. Pterional approach was adopted to remove the lesion and decompress the optic canal. Histological examination demonstrated a metastasis from a signet ring cell carcinoma. Postoperative CT showed near-total resection of the tumor and decompression of the optic canal. Visual defect remained unchanged.
Conclusion Metastasis should be considered in the differential diagnosis of the ACP lesions. The early suspicion and identification of this extremely rare pathological entity can be helpful for the prompt management of patients, especially in the absence of any other signs of oncological diseases.
Endoscopic Endonasal Approach for Intra- and Extraconal Orbital Pathologies
Authors: Melder Katie , Zwagerman Nathan , Gardner Paul A. , Wang Eric W. 
Published: August 2020

AbstractEndoscopic endonasal approaches offer an important alternative in the management of posterior inferomedial orbital pathology. Beginning with endoscopic orbital decompressions for Graves' disease, the endonasal corridor for the management of intra- and extraconal pathologies has continued to evolve. Endonasal removal of orbital cavernous hemangiomas is well described in the literature; however, many other benign and malignant pathologies of the medial orbit can be accessed through this approach. Advantages of the endonasal approach include improved visualization and decreased manipulation of orbital contents in the medial and posterior orbit. Additionally, for tumors that extend from the paranasal sinuses into the orbit, this corridor may be ideal for concurrent management. The current literature for this approach will be reviewed including the oncologic results, complications, limitations, and reconstructive needs along with pertinent anatomy. In addition, data from our own institution will be reviewed.
Clinical and Imaging Response to Trigeminal Schwannoma Radiosurgery: A Retrospective Analysis of a 28-Year Experience
Authors: Niranjan Ajay , Raju Sudesh S. , Kano Hideyuki , Flickinger John C. , Lunsford Lawrence Dade 
Published: August 2020

Abstract
Objective The purpose of this study was to evaluate long-term clinical outcomes and tumor control after stereotactic radiosurgery (SRS) for trigeminal schwannoma (TS).
Methods During a 28-year period (1989–2017), 50 patients underwent SRS for TS. The median patient age was 51 years (range: 15–87 years). A total of 17 patients had a previous tumor resection: 10 had a single procedure, 5 had two procedures, and 2 had three procedures. The median and mean times between tumor resection and SRS were 12 and 24 months (range: 1–90 months), respectively. Four patients had neurofibromatosis II (NF2). Based on location, tumors were classified as root type (7), ganglion type (22), or dumbbell type (21). The median radiosurgery target volume was 3.4 cm3 (range: 0.10–18 cm3), median target dose was 14 Gy (range: 12–20 Gy), and the median number of isocenters was 6 (range: 1–15). The median and mean times to last follow-up was 36.9 and 55.2 months (range: 4–205 months), respectively. Eighteen patients (36%) had longer than 5-year follow-up, and seven patients (14%) had longer than 10-year follow-up.
Results The tumor control rate was 92% and the clinical improvement or stabilization rate was 94%. After SRS, the rates of progression free survival (PFS) at 1, 5, and 10 years were 98, 84, and 84%, respectively. Factors associated with improved PFS were female sex (p = 0.014) and smaller tumor volume (p = 0.022). In this series, we did not find that tumor type (root, ganglion, and dumbbell) had a statistically significant correlation to PFS. Forty-seven patients had neurological signs or symptoms at presentation. At last follow-up, neurological signs or symptoms improved in 22/47 (47%), remained unchanged in 24/50 (48%), and worsened due to tumor progression in 3/50 (6%). One patient (2%) developed temporary symptomatic adverse radiation effect (ARE) and three additional patients (6%) had transient imaging evidence of peritumoral reactive edema but no new symptoms.
Conclusion As a single outpatient procedure, SRS was associated with long-term freedom from additional management in 84% of patients. Nearly half the treated patients experienced improvement in neurological symptoms or signs.
An Overview of Anxiety Disorders and Depression in Children with Epilepsy: A Literature Review
Authors: Gökçen Onur , Turgut Mehmet 
Published: August 2020

AbstractComorbid psychiatric disorders in children with epilepsy have long been a subject of medical literature. Many studies conducted by pediatric neurologists, neurosurgeons, psychiatrists, and psychologists have revealed that psychiatric disorders, including anxiety disorders and depression, are frequently seen in children and adolescents with epilepsy. Due to various etiologies behind epilepsy, causes, manifestation, and treatment of anxiety and depression all have unique aspects. We think there are multiple reasons behind anxiety disorders and depression in children with epilepsy, varying from the physiological nature of the epilepsy itself to the environmental factors such as family, parenting, and social status. In this article, we aim to review the causes, risk factors, and management of anxiety disorders and depression in children with epilepsy.