bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of renal support therapy on 5-year survival in patients discharged from the intensive care unit
Authors: Oliveros Henry , Buitrago Giancarlo 
Published: August 2020

Abstract
Background
Between 30 and 70% of patients admitted to the intensive care unit (ICU) have acute kidney injury (AKI), and 10% of these patients will require renal replacement therapy (RRT). A significant number of studies have compared the mortality of patients who require RRT versus those who do not require it, finding an increase in mortality rates in the short and medium term; however, few studies have evaluated the long-term survival in a mixture of patients admitted to the ICU.

Objective
To evaluate the impact of RRT on 5-year survival in patients with AKI admitted to the ICU

Methods
Using administrative databases of insurers of the Colombian health system, a cohort of patients admitted to the ICU between 1 January 2012 and 31 December 2013 was followed until 31 December 2018. ICD-10 diagnoses, procedure codes, and prescribed medications were used to establish the frequencies of the comorbidities included in the Charlson index. Patients were followed for at least 5 years to evaluate survival and establish the adjusted risks by propensity score matching.

Results
Of the 150,230 patients admitted to the ICU, 4366 (2.9%) required RRT in the ICU. Mortality rates for patients with RRT vs no RRT evaluated at ICU discharge, 1 year, and 5 years were 35%, 57.4%, and 67.9% vs 7.4%, 17.6%, and 30.1%, respectively. After propensity score matching, the hazard ratio was calculated for patients who received RRT and those who did not (HR, 2.46; 95% CI 2.37 to 2.56; p < 0.001), with a lower difference in years of survival for patients with RRT (mean effect in the treated) of − 1.86 (95% CI − 2.01 to to1.65; p < 0.001).

Conclusions
The impact of acute renal failure with the consequent need for RRT in patients admitted to the ICU is reflected in a decrease of approximately one quarter in 5-year survival, regardless of the different comorbidities.
Interreader reproducibility of the Neck Imaging Reporting and Data system (NI-RADS) lexicon for the detection of residual/recurrent disease in treated head and neck squamous cell carcinoma (HNSCC)
Authors: Abdelaziz Tougan Taha , Abdel Razk Ahmed Abdel Khalek , Ashour Manar Maamoun Mohamed , Abdelrahman Ahmed S. 
Published: August 2020

Abstract
Background
To evaluate the inter- and intrareader agreement and reproducibility of the NI-RADS scoring system and lexicon with contrast-enhanced computed tomography (CECT) and contrast-enhanced magnetic resonance imaging (CEMRI).

Methods
This retrospective study included 97 CECT and CEMRI scans from 58 treated cases of head and neck squamous cell carcinoma (HNSCC) after the exclusion of head and neck cancers (HNCs) other than SCC and noncontrast and poor quality CT and MRI scans, with a total of 111 primary targets and 124 lymph node (LN) targets. Two experienced readers independently scored the likelihood of residual/recurrence for these targets based on the NI-RADS criteria and filled in report templates for NI-RADS lexicon diagnostic features. Inter- and intraobserver reproducibility was assessed with Cohen’s kappa, and the percent agreement was calculated.

Results
Almost perfect interreader agreement was found for the final NI-RADS category of the primary lesions and LNs, with K = 0.808 and 0.806, respectively. Better agreement was found for CT than for MRI (K = 0.843 and 0.77, respectively, P value 0.001). There was almost perfect agreement for excluding tissue enhancement (K = 0.826, 95% CI = 0.658–0.993, P value 0.001), with a percent agreement of 96.4%, and substantial agreement for discrete nodular and diffuse mucosal enhancement (K = 0.826, 95% CI = 0.658–0.993, P value 0.001), with a percent agreement of 96.4%. There was fair agreement for focal mucosal nonmass and deep ill-defined enhancement. The intrareader agreement was almost perfect for most of the rated features (K ranging from 0.802 to 1), with the exception of enlarging discrete nodule/mass and focal mucosal nonmass-like enhancement, which had substantial intraobserver agreement (K ranging from 0.768 to 0.786).

Conclusion
The individual features of NI-RADS show variable degrees of confidence; however, the overall NI-RADS category was not significantly affected.
Exploring community perceptions in preparation for a randomised controlled trial of biofortified flour in Pakistan
Authors: Mahboob Usman , Ohly Heather , Joy Edward J. M. , Moran Victoria , Zaman Mukhtiar , Lowe Nicola M. 
Published: August 2020

Abstract
Background
Biofortification of staple food crops may be a cost-effective and sustainable approach to reducing micronutrient deficiencies in resource-poor settings with low dietary diversity. However, its success depends on uptake by the local population. This paper presents formative research conducted in a remote, rural community in North West Pakistan, prior to commencing a randomised controlled trial to test the effectiveness of consuming zinc-biofortified wheat flour for alleviating zinc deficiency. It explored local community members’ knowledge, understanding and attitudes towards biofortification and views on members of their community taking part in the trial.

Methods
Four focus group discussions were conducted with male and female community members (separately for cultural reasons) and four in-depth interviews were conducted with Jirga members—respected male elders. Participation was limited to households that were ineligible for the trial so that we could explore the perspectives of community members who were not influenced by the incentives of the trial. Focus group participants were selected at community events for transparency. Data collection took place at the local school and homes of Jirga members. Thematic analysis was undertaken, using a combination of deductive and inductive approaches to identify key themes.

Results
A total of 47 men and women participated in this study. Participants reported clear motivation to access and consume more nutritious flour, believing this would bring health benefits, particularly to women and children. Trusted members of the local community, including Jirga members and female health workers, should be involved in providing information on biofortified flour (and the trial) to increase levels of awareness and acceptance. Without their involvement, there is a risk that biofortified flour would be mistrusted. The cost of flour is the main factor affecting purchasing decisions, and biofortified flour will need to be cost-competitive to achieve widespread uptake in marginalised, rural communities.

Conclusion
This formative study generated rich, qualitative data from a range of community stakeholders to improve the understanding of important barriers and facilitators to the widespread acceptability and adoption of biofortified wheat. Implementation research such as this will inform future decision-making in relation to scaling up biofortified wheat in Pakistan.
Regional innovation system research trends: toward knowledge management and entrepreneurial ecosystems
Authors: López-Rubio Pedro , Roig-Tierno Norat , Mas-Tur Alicia 
Published: August 2020

AbstractThe regional innovation system (RIS) is a popular way of explaining a region’s development and competitiveness based on innovation activities and processes. In this paper, bibliometric techniques are used to analyze all RIS studies indexed in the Web of Science Core Collection (WoS CC) database as of December 2017. The goal of the analysis is to identify the main trends in RIS research. The evolution of the total number of publications and citations per year indicates that this research field has garnered considerable attention from the scientific community, public administrations, and international organizations. Analysis of the most common keywords and their co-occurrence sheds light on the conceptual framework of RIS research, where knowledge, innovation, clusters, policy, networks, systems, R&D, firms, and industry are key concepts. The 17 most influential RIS articles indexed in WoS CC are identified according to the total number of citations and the ratio of number of citations per year. Reviewing these 17 articles reveals 3 groups of underlying research trends: (1) research on innovation systems, which was mainly conducted in the 1990s, (2) research on knowledge management since the beginning of the 2000s, and (3) research on entrepreneurial ecosystems in recent years. Finally, analysis of citations to these 17 most influential RIS articles reveals strong interconnections according to the number of times they are cited together.
Treatment of dorsally dislocated distal radius fractures with individualized 3D printed bracing: an exploratory study
Authors: Janzing H. M. J. , Bessems S. A. M. , Ligthart M. A. P. , Van Lieshout E. M. M. , Theeuwes H. P. , Barten D. G. , Verhofstad M. H. J. 
Published: August 2020

Abstract
Background
The aim of this work was to develop a three-dimensionally (3D) printed brace for the acute treatment of dorsally dislocated and correctly reduced distal radius fractures (DRF). The hypothesis was that a brace shaped to the mirror image of the contralateral (non-fractured) wrist will have an optimal anatomical fit, resulting in improved comfort and lower rates of secondary fracture displacement.

Method
Validation: the circumference of both wrists and comfort of the brace were studied in healthy volunteers and effectiveness of the brace was evaluated in an ex vivo fracture model.
Clinical study: the brace was tested for comfort and effectiveness in patients with a well reduced unstable DRF.

Results
Validation: the circumference of both wrists may be different, the brace retained the reduction in the ex vivo fracture model and was well tolerated in the volunteers.
Clinical study: in DRF patients comfort scores were lower and pain scores higher compared to the healthy volunteers. After 3 and 5 weeks all patients were independent in ADL according to the Katz-index. Posttraumatic swelling subsided in the first week. In two of the five patients secondary fracture dislocation occurred.

Conclusions
Treatment of a dislocated DRF in the acute setting (day one) with a custom-made 3D printed brace, anatomically modelled from a 3D scan of the contralateral wrist, is possible. Difference between both wrists and posttraumatic swelling must be adapted for. The high rate of secondary fracture displacement led to early discontinuation of the study and a small sample size.

Trial registration
Name of the registry: ClinicalTrials.Gov
Trial registration number: NCT03848702
Date of registration: 02/21/2019, retrospectively registered
Population size, group and age structure of geladas (Theropithecus gelada) in escarpments of Eastern Tigray, Ethiopia: implication for conservation
Authors: Girmay Teklay , Dati Deribe 
Published: August 2020

AbstractBackgroundGeladas (Theropithecus gelada), endemic to Ethiopia, are distributed closely related to the escarpments and gorge systems of the country, and large populations are found in the Simien Mountain National Park. This study was conducted in Eastern Tigray, Northern Ethiopia, from February 2018 to August 2019 in order to determine population size and composition of geladas. Total count method was used to estimate the population structure of geladas. Observations of the group of geladas based on body size and morphological characteristics were used to classify age and sex categories of the population. SPSS Version 20 was used to analyze the data. Chi-square test was used to compare sex ratio of geladas and population size among the counting sites between wet and dry seasons.ResultsA total of 112 and 99 individual of geladas were counted during wet and dry seasons, respectively. Of the average gelada population recorded in this study, 11.4% were adult males, 30.3% were adult females, 12.8% were sub-adult males, 25.6% were sub-adult females, and 19.9% were unidentified juveniles. However, there was no statistically significant difference among the various age and sex groups of geladas counted during wet and dry season (χ2= 2.6, DF = 4,P> 0.05). Variations of group size along seasons were observed in this study. Sex ratio of adult male to adult female was 1:2.6 and 1:2.7 during the dry and wet seasons, respectively.ConclusionVery small gelada population size was recorded in the current study. An average of 105.5 geladas was recorded during the study period. As this is the first report of gelada population in escarpments of Eastern Tigray, population trend of the geladas cannot decide based on the current study.
Unemployment in Switzerland in the wake of the Covid-19 pandemic: an intertemporal perspective
Authors: Sheldon George 
Published: August 2020

AbstractThe following contribution compares the unemployment situation arising from the lockdown induced by the Covid-19 pandemic with previous employment crises in Switzerland. In addition, it forecasts the future trajectory of unemployment based on ongoing changes in hazard rates. From a historical perspective, current unemployment as well as that expected by the federal authorities in the medium term do not seem that dramatic. Current hazard rates present a different picture, however, predicting increases in both the unemployment rate and long-term unemployment to record levels.
Hop-induced formation of ethyl esters in dry-hopped beer
Authors: Brendel Sabrina , Hofmann Thomas , Granvogl Michael 
Published: August 2020

Abstract
Fruity smelling esters play an important role for the aroma of hops and beer and they have been characterized as key aroma compounds in different hop varieties. Studies on the transfer of hop-derived compounds into beer during dry-hopping showed calculated transfer rates of different ethyl esters far above 100%, leading to the assumption that these esters must be newly formed. To investigate this formation, dry-hopping was imitated in water to eliminate the influence of the beer matrix on the formation of these odorants. Thereby, the formation of ethyl esters of 2-methylbutanoic acid, 3-methylbutanoic acid, and methylpropanoic acid, induced by the addition of hops, was shown. Different approaches inhibiting enzyme activities and experiments with different hop extracts might lead to the assumption that enzymes are involved in the formation of these esters, beside possible transesterification.

Graphical abstract
Serum level of transforming growth factor-beta1 in major idiopathic interstitial pneumonia
Authors: Zakaria Mohamed W. , El-Korashy Reem I. , Selim Samah , Badawy Ingy , Amum Kwashi J. 
Published: August 2020

Abstract
Background
Different inflammatory cytokines play a role in the mechanism and pathogenesis of fibrosis in idiopathic interstitial pneumonia (IIP). Transforming growth factor-beta1 (TGF-β1) has become a subject of interest. The aim of the work is to measure the serum level of TGF-β1 in different forms of major IIP and to find out its relation to the patients’ clinical and arterial blood gases’ parameters.

Results
The patients’ group showed significant elevation of serum level of TGF-β1 in comparison with the control group (P value < 0.001). In patients with IPF, the serum level of TGF-β1 was not significantly increased compared to patients with other forms of major IIP (mean ± SD = 300 ± 84.52 versus 340 ± 131.20 pg/ml, P value = 0.32). There was an inverse negative correlation between the age and serum level of TGF-β1 (r = − 0.39; P = 0.03). An inverse non-significant correlation was found between the serum level of TGF-β1 and the dyspnoea score (r = − 0.30, P = 0.11). However, there was a significant positive correlation between the serum level of TGF-β1 and the distance of 6-MWT (r = 0.44; P = 0.02). It was also found that there was a positive correlation between the serum level of TGF-β1 and both arterial oxygen pressure (PaO2) (r = 0.39, P = 0.03) and arterial oxygen saturation (r = 0.33, P = 0.07).

Conclusion
Serum level of TGF-β1 is elevated in patients with IIP and it positively correlated to both 6-MWD and PaO2. Further larger studies are needed to evaluate its prognostic value.
A single cell RNA sequencing resource for early sea urchin development
Authors: Foster Stephany , Oulhen Nathalie , Wessel Gary 
Published: August 2020

ABSTRACT
Identifying cell states during development from their mRNA profiles provides insight into their gene regulatory network. Here, we leverage the sea urchin embryo for its well-established gene regulatory network to interrogate the embryo using single cell RNA sequencing. We tested eight developmental stages in Strongylocentrotus purpuratus, from the eight-cell stage to late in gastrulation. We used these datasets to parse out 22 major cell states of the embryo, focusing on key transition stages for cell type specification of each germ layer. Subclustering of these major embryonic domains revealed over 50 cell states with distinct transcript profiles. Furthermore, we identified the transcript profile of two cell states expressing germ cell factors, one we conclude represents the primordial germ cells and the other state is transiently present during gastrulation. We hypothesize that these cells of the Veg2 tier of the early embryo represent a lineage that converts to the germ line when the primordial germ cells are deleted. This broad resource will hopefully enable the community to identify other cell states and genes of interest to expose the underpinning of developmental mechanisms.
Historical series of cases of COVID-19 in brazilian regions in the year of 2020
Authors: Gouveia Guilherme Pertinni de Morais , Gouveia Samara Sousa Vasconcelos , Vasconcelos Samila Sousa , Silva Elisson de Sousa Mesquita , Medeiros Rebeca Galdino , Da Silva Rosangela Lago 
Published: August 2020

Aim: To analyze the incidence and lethality of COVID-19 in Brazil, through a historical series. Methods: Retrospective ecological study carried out by analyzing biweekly time series with secondary data from Brazilian regions and states, was on the state and integral health sites of the State of Health and IntegraSUS, related to SARS-CoV disease, from March to May 2020. Results: All states showed an increasing incidence trend, except Ceará. The highest lethality found was from Piauí. However, in the last analyzed period, the states of Rio de Janeiro, Pernambuco, São Paulo and Ceará stood out. The North had an increased incidence in relation to the others and the Southeast had the highest lethality rate. Conclusion: There was an increasing trend in incidence in all states, except Ceará. Piauí had the highest lethality coefficient. Considering the regions, the North showed an increasing trend in incidence and lethality was higher in the Southeast.
Last-Place Aversion in Queues
Authors: Buell Ryan W. 
Published: August 2020

This paper documents the effects of last-place aversion in queues and its implications for customer experiences and behaviors, as well as for operating performance. An observational analysis of customers queuing at a grocery store, and four online studies in which participants waited in virtual queues, revealed that waiting in last place diminishes wait satisfaction while increasing the probabilities of switching and abandoning queues, with detrimental implications for queuing systems. The research suggests that last-place aversion can lead to maladaptive customer behaviors—switching behaviors that increase wait times and abandoning when the benefits of waiting are most pronounced. The results indicate that this behavior is partially explained by the inability to make a downward social comparison; namely, when no one is behind a queuing individual, that person is less certain that continuing to wait is worthwhile. Furthermore, this paper provides evidence that queue transparency is an effective service design lever that managers can use to reduce the deleterious effects of last-place aversion in queues. When people cannot see that they are in last place, the behavioral effects of last-place aversion are nullified; and when they can see that they are not in last place, the tendency to renege is greatly diminished. Finally, a system-level experiment, in which pairs of queues were created and analyzed, reveals that when the effects of last-place aversion are addressed, overall abandonment decreases, such that with equivalent arrival and service rates, total service provision can be increased. This paper was accepted by Vishal Gaur, operations management.
Effect of COVID-19 on a rural orthopaedic hip fracture service
Authors: Cheruvu Manikandar Srinivas , Bhachu Davinder Singh , Mulrain Jill , Resool Shko , Cool Paul , Ford David James , Singh Rohit Amol 
Published: August 2020

Aims Our rural orthopaedic service has undergone service restructure during the COVID-19 pandemic in order to sustain hip fracture care. All adult trauma care has been centralised to the Royal Shrewsbury Hospital for assessment and medical input, before transferring those requiring operative intervention to the Robert Jones and Agnes Hunt Orthopaedic Hospital. We aim to review the impact of COVID-19 on hip fracture workload and service changes upon management of hip fractures. Methods We reviewed our prospectively maintained trust database and National Hip Fracture Database records for the months of March and April between the years 2016 and 2020. Our assessment included fracture pattern (intrascapular vs extracapsular hip fracture), treatment intervention, length of stay and mortality. Results We treated 288 patients during March and April between 2016 and 2020, with a breakdown of 55, 58, 53, 68, and 54 from 2016 to 2020 respectively. Fracture pattern distribution in the pre-COVID-19 years of 2016 to 2019 was 58% intracapsular and 42% extracapsular. In 2020 (COVID-19 period) the fracture patterns were 65% intracapsular and 35% extracapsular. Our mean length of stay was 13.1 days (SD 8.2) between 2016 to 2019, and 5.0 days (6.3) days in 2020 (p < 0.001). Between 2016 and 2019 we had three deaths in hip fracture patients, and one death in 2020. Hemiarthroplasty and dynamic hip screw fixation have been the mainstay of operative intervention across the five years and this has continued in the COVID-19 period. We have experienced a rise in conservatively managed patients; ten in 2020 compared to 14 over the previous four years. Conclusion There has not been a reduction in the number of hip fractures during COVID-19 period compared to the same time period over previous years. In our experience, there has been an increase in conservative treatment and decreased length of stay during the COVID -19 period. Cite this article: Bone Joint Open 2020;1-8:500–507.
Theoretical investigation of an enhanced Goos–Hänchen shift sensor based on a BlueP/TMDC/graphene hybrid
Authors: Ji Qizheng , Yan Bin , Han Lei , Wang Jin , Yang Ming , Wu Chuan 
Published: August 2020

The Goos–Hänchen (GH) shift caused by blue phosphorene/transition metal dichalcogenides (BlueP/TMDCs) and graphene surface plasma resonance (SPR) in Kretschmann configuration are studied theoretically. In this structure, graphene and BlueP/TMDCs coated on Cu thin film are optimized to improve the GH shift. The highest GH shift of sensor

Cu

-

BlueP

/

WS
2

–graphene is

1004

λ

with three layers

BlueP

/

WS
2

and a graphene monolayer. For the sensing application, the sensitivity corresponding to the optimal GH shift is

3.199

×

10

6

λ

/

RIU

, which is 210.8 times higher than the traditional Cu film, 181.4 times higher than the

Cu

-

BlueP

/

WS
2

(monolayer) structure, and 56.6 times higher than the Cu–graphene structure. Therefore, the SPR sensor with high GH shift can be extensively used in the fields of chemical, biomedical, and environmental monitoring.