bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chondroblastoma of the Patella with Secondary Aneurysmal Bone Cyst, an Easily Misdiagnosed Bone Tumor: A Case Report with Literature Review
Authors: Zheng Jianping , Niu Ningkui , Shi Jiandang , Zhang Xu , Zhu Xi , Wang Jiali , Liu Changhao 
Published: September 2020

Abstract
Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that common affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. However, CB is extremely rare in the patella, especially in combination with secondary aneurysmal bone cyst (ABC). In fact, this complicated condition can be easily confused with other common bone tumors of the patella. Case presentation: We have presented here the case of a 30-year-old man who was suffering from the anterior knee pain for the past 6 months that got aggravated since the past 2 weeks. Osteolytic bone destruction in the patella could be detected in both his X-ray and computed tomography (CT) examinations, while the magnetic resonance imaging (MRI) detected a fluid level. Accordingly, secondary ABC was presumed. We diagnosed the condition as giant cell tumor (GCT) with secondary ABC and accordingly performed curettage inside the focus region by autogenous bone grafting in accordance with the patient's medical history, physical manifestations, results of physical and ancillary examinations, and the disease characteristics. However, the in- and postsurgical outcomes indicated that the patient’s histopathology was consistent with that of typical CB, suggesting a definitive error in diagnosis. Accordingly, the patient was finally diagnosed with patella CB along with secondary ABC.Conclusions: Past studies have demonstrated that the 3 commonest bone tumors affecting the patella are GCT, CB, and ABC. We believe that the condition of patella GCT and CB accompanied with secondary ABC can be easily misdiagnosed. Performing incision biopsy or excision biopsy and conducting histological examination may be the most effective approach to identify and distinguish among these diseases.
Developing Strategy of Clinical Practice Guidelines for Post-intensive Care Syndrome: A Systematic Review of 14 Practice Guidelines and 10 Consensus Statements
Authors: He Min , Wang Ying , Zhang Xi-Ying , Wang Chen-Qiong , Zheng Xiao-Tian , Yang Ya-Hui , Xiang Qian-Ling , Zhang Fang , Fu Bao , Hu Ru-Jun , Luo Lan , Jiang Zhixia 
Published: September 2020

Abstract
BackgroundPost-intensive care syndrome (PICS) seriously affects the quality of life of patients and their caregivers. This study systematically evaluates PICS related guidelines and consensuses to provide methodological and strategic guidance for the development and improvement of these guidelines and consensus.MethodsAn Internet search of PICS specific or related guidelines and consensus statements was conducted among academic databases and the websites. The AGREE II was used to evaluate their methodological quality. The themes and contents were evaluated based on the definition of PICS and the “patient-clinical problem-intervention-target” framework.ResultsWe included fourteen guidelines and 10 expert consensuses. The mean AGREE II score for scope and purpose was 86.89% ± 16.12%/ 79.47% ± 11.80%, 55.86% ± 29.17%/16.72% ± 16.39% for stakeholder involvement, 76.35% ± 15.82% /36.09% ±26.05% for rigor of development, 88.03% ± 15.55%/58.84% ± 28.94% for clarity of presentation, 61.79% ± 23.16/32.95% ± 20.91% for applicability, and 66.67% ± 37.96% /28.79% ± 36.54% for editorial independence in Guidelines/Consensus. Most only described a single or series of clinical related issues of PICS; only applicable for critically ill patients with clinical problems of ICUAW, pain, sleep disruption, agitation, and delirium. The interventions included risk assessment, monitoring/diagnosis, prevention, treatment, safety criteria, and home care of one or more symptoms of PICS.ConclusionsOur results suggested that development and improvement of guidelines/consensus should focus on refining the methodology, strengthening quality control, and improving presentation clarity, editorial independence, and applicability. The results may provide new idea for a future guidelines and consensus statements.
High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana
Authors: Brown Charles , Pappoe-Ashong Prince , Duah Nancy , Ghansah Anita , Asmah Harry , Afari Edwin , Koram Kwadwo 
Published: September 2020

Abstract
Background
The Duffy-negative phenotype is a condition which is thought to confer complete resistance against blood infection with Plasmodium vivax. However, recent studies from different malaria-endemic regions including western Africa have now shown that P. vivax can infect red blood cells (RBCs) and cause clinical disease in Duffy-negative people. The actual prevalence of P. vivax in local populations in Ghana is unknown. In addition, little information is available about the distribution of Duffy genotypes in Ghana. We determined the prevalence of P. vivax and the distribution of Duffy genotypes in Ghana.
Methods
DNA was extracted from dried blood spots (DBS) collected from 952 subjects (845 malaria patients and 107 asymptomatic persons) from nine locations in Ghana. Plasmodium species identification was carried out by nested polymerase chain reaction (PCR) amplification of the small-subunit rRNA genes; P. vivax was further characterized by PCR analysis of the central region of the Pvcsp gene. Duffy blood group genotyping was performed by PCR with sequence-specific primers (PCR-SSP) to detect the presence of the FYES allele.
Results
No cases of P. vivax were detected in any of the samples by both PCR methods used. Majority of infections (542, 94.8%) in the malaria patient samples were due to P. falciparum with only 1 infection (0.0017%) and 2 infections (0.0034%) due to P. malariae and P. ovale, respectively. No case of mixed infection was identified. Of the samples tested for the FYES allele from all the sites, 90.5% (862/952) had the FYES allele. All positive samples were genotyped as FY*B-33/FY*B-33 (Duffy-negative homozygous) and therefore classified as Fy(a-b-).
Conclusions
No cases of P. vivax were detected by both PCRs and 90.5% of the subjects tested carried the FYES allele. The lack of P. vivax infections observed can be attributed to the high frequency of the FYES allele that silences erythroid expression of the Duffy. These results provide insights on the host susceptibility for P. vivax infections that has before not been investigated in Ghana.
Serum apolipoprotein A-1 is related to inflammatory factors in the acute phase of gout
Authors: Zhang Baoyu , Wang Yuan , Jia Xiaoxia , Mu Lin , Wang Xiaobo 
Published: September 2020

Abstract
BACKGROUNDTo observe the correlation between serum apolipoprotein A-1(apoA-1) and inflammatory factors in patients with gouty arthritis. METHODSFrom February to September 2020, 97 patients with gout (gout group) and 70 healthy controls (control group) were selected as the study subjects，who were admitted to the outpatient department of Beijing lu he hospital affiliated to capital medical university.97 patients in the gout group were in the acute phase. Serum concentrations of apoA-1, NLRP3 inflammasome （NACHT-LRR-PYD protein 3,NLRP3), interleukin-1 (IL-1) and interleukin-9 (IL-9) were detected. The correlation of serum apoA-1 concentration, gout related inflammatory factors (NLRP3, IL-1 beta, IL-9) and other clinical and laboratory indicators was analyzed. RESULTSThe serum apoA-1 concentration in the gout group was lower than that in the control group (P<0.05). With the increase of serum uric acid level, serum apoA-1 concentration decreased（R2=-0.3160，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc, and the correlation remained（OR=-3.36，P<0.05）. With the increase of serum IL-1 beta concentration, serum apoA-1 concentration decreased（R2=-0.3993，P<0.05）. Multiple linear analyses were performed to increase blood glucose, blood lipid, liver and kidney, etc., and the correlation remained（OR=-2.95，P<0.05）. CONCLUSIONSIn the acute stage of gout, as the serum uric acid level increases, the serum IL-1β concentration increases and the apoA-1 concentration gradually decreases, which may indicate that apoA-1 participates in the inflammatory response of gout to a certain extent.
Fleeing lockdown and its impact on the size of epidemic outbreaks in the source and target regions - a COVID-19 lesson
Authors: Barbarossa Maria Vittoria , Bogya Norbert , Dénes Attila , Röst Gergely , Varma Hridya Vinod , Vizi Zsolt 
Published: September 2020

Abstract
The COVID-19 pandemic forced authorities worldwide to implement moderate to severe restrictions in order to slow down or suppress the spread of the disease. It has been observed in several countries that a significant number of people fled a city or a region just before strict lockdown measures were implemented. This behavior carries the risk of seeding a large number of infections all at once in regions with otherwise small number of cases. In this work, we investigate the effect of fleeing on the size of an epidemic outbreak in the region under lockdown, and also in the region of destination. We propose a mathematical model that is suitable to describe the spread of an infectious disease over multiple geographic regions. Our approach is flexible to characterize the transmission of different viruses. As an example, we consider the COVID-19 outbreak in Italy. Projection of different scenarios shows that (i) timely and stricter intervention could have significantly lowered the number of cumulative cases in Italy, and (ii) fleeing at the time of lockdown possibly played a minor role in the spread of the disease in the country.
Precise determination of the effect of temperature on the density of solid and liquid iron, nickel, and tin
Authors: Kamiya Asaka , Terasaki Hidenori , Kondo Tadashi 
Published: September 2020

Abstract
Density and thermal expansion coefficient of metals are fundamental characteristics to describe the equation of state. Especially for liquid metals, the reported data for density and thermal expansion coefficient vary in the literature, even at ambient pressure. To determine the density of solid and liquid metals precisely at high temperatures and ambient pressure, we have developed a high-temperature furnace. The densities of solid Sn, Ni, and Fe were determined from the sample image with an uncertainty of 0.11–0.7% in the temperature range of 285–1803 K with increments of 1–10 K. The density of solid Sn decreased linearly with increasing temperature up to 493 K, and then the decrease became drastic until the melting temperature (Tm) was reached. By contrast, for solid Ni and Fe, the densities decreased linearly with increasing temperature up to the Tm (1728 and 1813 K) without any drastic density drop near Tm. This suggests that Ni and Fe do not exhibit the “premelting effect.”
The density of liquid Fe was determined with an uncertainty of 0.4–0.7% in the range of 1818–1998 K with temperature increments of 5 K. The obtained thermal expansion coefficient (α) of liquid Fe was well approximated as either a constant value of α = 2.42(1) × 10–4 K–1 or a linear function of temperature (T); α = 1.37(10) × 10–3 – [6.0(6) × 10–7]T [K–1] up to at least 2000 K.
Aging Protocols and Their Effects on Bond Strength of Total-Etch and Self-Etch Adhesive Systems to Dentin
Authors: Gomes Isabella A. , N. Gomes Mário G. , Amaral Flávia L. B. , G. França Fabiana M. , Basting Roberta T. , Bandeca Matheus C. , Diniz Rafael S. , Gonçalves Letícia M. , de J. Tavarez Rudys R. , Turssi Cecilia P. 
Published: September 2020

Objective:
This study investigated whether different aging protocols have effects on the bond strength of total-etch and self-etch adhesive systems to dentin substrate.

Methods:
Molars were sectioned exposing the dentin, which was submitted to restorative procedures using two-step total-etch (ASB, Adper SingleBond2), two-step self-etch (CLF, Clearfil SEBond), or one-step self-etch (OPT, Optibond All-in-One) system and resin composite. The obtained blocks were sectioned to result in sticks to be submitted to bond strength and failure mode tests after 24h storage in distilled water (DW), or 180-day aging protocols in DW, artificial saliva (AS), citric acid (CA), or thermal cycling (TC). The types of failures were classified as adhesive, cohesive in dentin, cohesive in composite resin, and mixed. Data were analyzed using ANOVA followed by Tukey’s test (α=5%). The failure modes were descriptive under the relative frequencies form.

Results:
It was observed that ASB presented the higher bond strength(p<0.05), while CLF and OPT did not demonstrate differences between them(p>0.05) after 24h. The bond strength obtained with ASB significantly overcame that of OPT when stored in DW or AS for 180 days (p<0.001). In these storing mediums, ASB did not differ from CLF(p>0.05), while in CA or TC the values of CLF were significantly lower (p<0.001). In TC aging, the values presented by OPT did not differ from ASB(p>0.05), both of which had higher values than CLF(p<0.05). The predominant failure mode was adhesive.

Conclusion:
For the two-step total-etch and two-step self-etch adhesives, the influence of aging in AS and TC was equivalent to that of storage in DW. The most deleterious effects occurred in CA, a situation in which self-etch adhesives displayed worse performance than the conventional type.
Potential Antibacterial Flavonoid from Buah Merah (Pandanus conodieus Lam.) Against Pathogenic Oral Bacteria of Enterococcus faecalis ATCC 29212
Authors: Herdiyati Yetty , Atmaja Harold Eka , Satari Mieke Hemiawati , Kurnia Dikdik 
Published: September 2020

Background:
Dental caries is an oral disease generated by pathogenic bacteria, Enterococcus faecalis, which is most frequently found in teeth with pulp necrosis. On the other hand, the use of the medicinal plant to treat pathogenic disease, including caries is an alternative option, which consumes synthetic drug having a side effect.

Objective:
The purpose of this study is to isolate antibacterial agents from Buah Merah (Pandanus conoideus Lam) and to test the antibacterial activity of those compounds against Enterococcus faecalis ATCC 29212.

Methods:
Isolation of the antibacterial constituents from Buah Merah used a combinational column chromatography technique which include a normal and reversed-phase. The chosen fraction of each separation is based on the most active fraction. The compounds at various concentrations, 1000 - 20000 μg/mL, were assessed against E. faecalis ATCC 29212 by agar disc diffusion method, and chlorhexidine 2000 μg/mL was used as a positive control.

Results:
Four compounds isolated from Buah Merah were determined as flavonoid 1, diterpenoid 2, and two fatty acid derivatives 3 and 4. The compounds were then tested against E. faecalis cultured to find inhibition zones, and the study found that only compound 1 identified as Quercetin-3-O-glucose showed an inhibited zone 88 mm at 20000 ppm.

Conclusion:
This study demonstrated that ethyl acetate fraction of Buah Merah contains an antibacterial flavonoid active against E. faecalis. This research gives information for the use of this plant in herbal medicine and contributes to the necessity of a new antibacterial agent for oral infectious disease. Moreover, this data can be based on information to find the substituted antiseptic applied in the dentistry field.
High Titer of Antibody Against Pneumococcal IgA1 Protease in Healthy Individuals
Authors: Gholami Mina , Afshar Davoud , Kheirandish Mozhgan , Rafiee Farzaneh , Ranjbar Reza , Hasanzadeh Amir 
Published: September 2020

Background and Objectives:
Considering rising antibiotic resistance in various strains of Streptococcus pneumoniae, there is a need to find new immunogenic candidates for developing pneumococcal vaccines. Immunoglobulin A1 (IgA1) protease is one of the virulence factors playing an important role in the pathogenesis of S. pneumoniae infections. In the present study, we aimed to evaluate the titer of antibody against pneumococcal recombinant IgA1 protease in the serum of healthy humans.

Materials and Methods:
A part of the IgA1 protease gene (705 bp) from S. pneumonia ATCC 49619 was amplified by PCR and then digested using restriction enzymes and ligated by the pET28a expression vector. The recombinant protein was expressed in E. coli BL21 strain. Affinity chromatography was used to purify the protein. The titer of antibody against the recombinant protease was determined in healthy individuals in three age groups of <2, 2-40, and > 40 years using indirect Enzyme-Linked Immunosorbent Assay (ELISA).

Results:
The expression and purification of the IgA1 recombinant protease were successful. The concentration of the purified protein was determined as 1.013 mg/ml using the NanoDrop method. The titer of anti-recombinant IgA1 protease antibody (20, 40, 80 and 160) showed a significant correlation with age (p-value<0.05). According to our results, the antibody titer was desirable, especially in individuals over two years old.

Conclusion:

In the present study, desirable antibody titers against the pneumococcal recombinant IgA1 protease were seen in the three groups’ serum of healthy individuals. However, a significant correlation was not totally observed among groups.
Pengelolaan edu-wisata mangrove berbasis masyarakat : studi kasus di Desa Gedangan, Purwodadi, Purworejo, Jawa Tengah, Indonesia
Authors: Setiyaningrum Ika Feni , Harini Rika , Wirasanti Niken 
Published: September 2020

Ekosistem mangrove memiliki manfaat fisik, biologis, maupun ekonomis. Pengelolaan mangrove menjadi ekowisata adalah model pemanfaatan mangrove yang bernilai ekonomis dan berkelanjutan. Penelitian ini bertujuan untuk mengetahui kondisi mangrove eksisting dan model pengelolaan wisata mangrove yang dilakukan oleh masyarakat Gedangan. Penelitian dilakukan dengan menggunakan metode transect line plot, wawancara key informan, dan membagikan kuisioner kepada masyarakat. Berdasarkan hasil penelitian dapat diketahui bahwa kondisi mangrove eksisting didominasi oleh R.mucronata yang merupakan hasil program tanam mangrove pemerintah setempat sejak tahun 2011. Kondisi vegetasi kategori pancang tergolong rapat, sedangkan pada tingkat pohon tergolong jarang. Mangrove Gedangan dikelola menjadi wisata edukasi atas inisiatif masyarakat setempat dengan modal swadaya. Terdapat dukungan dari komunitas eksternal maupun pemerintah setempat dalam pengelolaannya. Penanaman mangrove masih terus dilakukan oleh pemerintah maupun lembaga pendidikan setempat. Peraturan pelarangan perusakan mangrove telah diterapkan. Dampak ekonomi yang dirasakan masyarakat antara lain menjadi sumber penghasilan pokok maupun tambahan dengan mengambil berbagai sumber daya ekosistem mangrove. Mangrove ecosystems have physical, biological and economic benefits. Mangrove management into ecotourism is a model of the use of mangroves that have economic and sustainable value. This study aims to determine the existing mangrove conditions and mangrove tourism management models carried out by the local community. The study was conducted using the transect line plot method, key informant interviews, and distributing questionnaires to the community. Based on the results of the study, it can be seen that the existing mangrove conditions are dominated by R. mucronata which is the result of the local government's mangrove planting program since 2011. The condition of the sapling category is classified as dense, while at the tree category is classified as rare. Mangrove in Gedangan is managed as an educational tourism at the initiative of the local community with self-help capital. There is support from external communities and the local government in its management. Mangrove planting is still being carried out by the government and local education institutions. Regulations prohibiting mangrove destruction have been implemented. The economic impacts felt by the community include being a source of basic and additional income by taking various mangrove ecosystem resources.
The efficacy of 3D printing-assisted surgery in treating distal radius fractures: systematic review and meta-analysis
Authors: Zhu Dongming , Zhang Zhen , Zhang Jie , Chen Duoyun , Shan Yuzhou , Xie Bin , Liu Pengran , Yan Lianqi 
Published: September 2020

Aim:
To compare the efficacy of 3D printing-assisted surgery with routine surgery in the treatment of distal radius fractures to evaluate whether 3D printing technology has more advantages.
Materials & methods:
To retrieve all published studies that compared the efficacy of 3D printing-assisted surgery with routine surgery for distal radius fractures. Operation time, frequency of intraoperative fluoroscopy, blood loss and other outcomes were assessed.
Results:
The results suggested that 3D printing-assisted surgery was better than routine surgery in the fields of operation time, frequency of intraoperative fluoroscopy, and blood loss.
Conclusion:
In the treatment of distal radius fractures, 3D printing-assisted surgery may be superior to routine surgery.
A língua/linguagem e o jogo de xadrez: perspectivas teóricas em Saussure e Wittgenstein
Authors: Pilotto Figueiredo Camila 
Published: September 2020

O presente artigo possui como objetivo abordar a noção de língua/linguagem em Saussure e em Wittgenstein através de suas analogias com o jogo de xadrez. Iniciaremos apresentando a metáfora do jogo de xadrez em cada um dos pensadores, evidenciando como as analogias por eles realizadas se inserem em suas teorias e, em consequência, elucidam seus pontos de vista acerca da noção de língua/linguagem; por fim, faremos uma análise comparativa das analogias de ambos os pensadores, avaliando em que medida elas se aproximam e se distanciam umas das outras, além de observarmos os limites de aproximação entre língua e jogo de xadrez em cada analogia.
Differences in Learning Outcomes of Chemistry through Cooperative Learning Model Type Make a Match and Numbered Head Together on the Material of Electrolyte and Nonelectrolyte Solution of Students Class X in SMA Negeri 9 Palu
Authors: Qamariya Nur , Jura Minarni R. , Afadil Afadil 
Published: September 2020

Application of learning model is expected to build good communication between students with teachers and students with students in an effort to improve understanding of a concept. This study aimed to determine the differences in the learning outcomes of chemistry through cooperative learning model type make a match and numbered head together in the material of electrolyte and nonelectrolyte solution of students class X SMA Negeri 9 Palu. This type of research was pre-experimental with the static group pretest-posttest design. The sample used in this research was the students of class Xa (n = 23) as the first experiment 1 and students of class Xb (n = 23) as the second experiment 2 with. The result of data analysis obtained, the mean value of the experiment class 1 was 74.24 and in the experiment class 2 was 67.28. The result of hypothesis testing with t-test statistic on two side was obtained - ttable ≤ tcount ³ + ttable that was (-1.68 <3.27> +1.68 with significant level (α = 0.05) and degrees of freedom = 44. This indicates that H0 was rejected and Ha was accepted so that it can be concluded that there are differences in the students’ learning outcomes of chemistry through cooperative learning model type make a match and numbered head together in the material of electrolyte and nonelectrolyte solution of class X SMA Negeri 9 Palu.