bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Multicomponent Exercise Interventions in Older Adults With Dementia: A Meta-Analysis
Authors: Borges-Machado Flávia , Silva Nádia , Farinatti Paulo , Poton Roberto , Ribeiro Óscar , Carvalho Joana 
Published: July 2020

Abstract

Background and Objectives
Multicomponent training (MT) combines aerobic, strength, postural, and balance exercises and may be a promising intervention strategy for dementia. This meta-analysis study aims to systematize evidence concerning the effectiveness of MT in physical fitness, cognition, and functionality on activities of daily living (ADL) in older adults with dementia and to identify moderation patterns regarding training variables.

Research Design and Methods
4 databases were systematically searched to locate potential trials through March 2019. A total of 2,312 records were identified and a final set of 17 manuscripts reviewed; of these, 6 satisfied all eligibility criteria.

Results
Samples sizes ranged from 27 to 170 participants; MT programs lasted between 4 weeks and 12 months, took place from a daily basis to twice a week, and sessions ranged from 30 to 60 min. The TESTEX scale was used to analyze the methodological quality, and the funnel plots to assess the risk of bias. This meta-analysis revealed that MT interventions benefit older adults with dementia regarding ADL performance (effect size = 0.313 [0.16–0.46]; p &lt; .01), but the evidence was not sufficiently robust to determine the effectiveness of MT on cognitive function and physical fitness, particularly, on agility.

Discussion and Implications
MT may be an important nonpharmacological strategy to enhance ADL functionality on older adults with dementia. Findings suggest that long-term interventions are more prevalent than high-frequency and longer duration exercise sessions. Further evidence is needed for acknowledging its benefits in specific cognitive abilities and physical fitness. This meta-analysis is registered in PROSPERO (no. CRD42020141545).
Structural and related studies on Mevo lectin from Methanococcus voltae A3: the first thorough characterization of an archeal lectin and its interactions
Authors: Sivaji Nukathoti , Suguna Kaza , Surolia Avadhesha , Vijayan Mamannamana 
Published: July 2020

Abstract
Crystallographic and solution studies of Mevo lectin and its complexes, the first effort of its kind on an archeal lectin, reveal a structure similar to β-prism I fold lectins from plant and animal sources, but with a quaternary association involving a ring structure with seven-fold symmetry. Each subunit in the heptamer carries one sugar binding site on the first Greek key motif. The oligomeric interface is primarily made up of a parallel β-sheet involving a strand of Greek key I of one subunit and Greek key ΙΙΙ from a neighboring subunit. The crystal structures of the complexes of the lectin with mannose, αMan(1,2)αMan, αMan(1,3)αMan, a mannotriose and a mannopentose revealed a primary binding site similar to that found in other mannose specific β-prism I fold lectins. The complex with αMan(1,3)αMan provides an interesting case in which a few subunits have the reducing end at the primary binding site, while the majority have the nonreducing end at the primary binding site. The structures of complexes involving the trisaccharide and the pentasaccharide exhibit cross-linking among heptameric molecules. The observed arrangements may be relevant to the multivalency of the lectin. Phylogenetic analysis of amino acid sequences indicates that Mevo lectin is closer to β-prism I fold animal lectins than with those of plant origin. The results presented here reinforce the conclusion regarding the existence of lectins in all three domains of life. It would also appear that lectins evolved to the present form before the three domains diverged.
Inequality of opportunities in health and death: an investigation from birth to middle age in Great Britain
Authors: Bricard Damien , Jusot Florence , Trannoy Alain , Tubeuf Sandy 
Published: July 2020

Abstract

Objective
We assess the existence of unfair inequalities in health and death using the normative framework of inequality of opportunities, from birth to middle age in Great Britain.

Methods
We use data from the 1958 National Child Development Study, which provides a unique opportunity to observe individual health from birth to the age of 54, including the occurrence of mortality. We measure health status combining self-assessed health and mortality. We compare and statistically test the differences between the cumulative distribution functions of health status at each age according to one childhood circumstance beyond people’s control: the father’s occupation.

Results
At all ages, individuals born to a ‘professional’, ‘senior manager or technician’ father report a better health status and have a lower mortality rate than individuals born to ‘skilled’, ‘partly skilled’ or ‘unskilled’ manual workers and individuals without a father at birth. The gap in the probability to report good health between individuals born into high social backgrounds compared with low, increases from 12 percentage points at age 23 to 26 at age 54. Health gaps are even more marked in health states at the bottom of the health distribution when mortality is combined with self-assessed health.

Conclusions
There is increasing inequality of opportunities in health over the lifespan in Great Britain. The tag of social background intensifies as individuals get older. Finally, there is added analytical value to combining mortality with self-assessed health when measuring health inequalities.
Productive Pacifists: The Rise of Production-Oriented States and Decline of Profit-Motivated Conquest
Authors: Markowitz Jonathan N , Mulesky Suzie , Graham Benjamin A T , Fariss Christopher J 
Published: July 2020

Abstract
Scholarship suggests the profits from conquest have decreased over time. Given this, why were some states faster to abandon profit-motivated conquest, and why are some still seeking wealth from territorial control? We argue that land-rent dependence influences a regime's economic preference for territory. The more a state depends on rents extracted from land (i.e., the more land-oriented the economy), the greater its willingness to invest in securing control of territory. We develop a novel measure of land orientation, with 200 years of data, to evaluate the linkages between land orientation and military competition over territory. Across 160 regression models, we find robust evidence that land orientation predicts territorial competition. These results hold in both democracies and autocracies. The global reduction in land-oriented states offers a plausible explanation for the decline in the number of large-scale territorial conquests. Our findings also explain why some states retain strong economic motivations for conquest.
Simultaneous Quantification of 38 Psychotropic Drugs and Relevant Metabolites in Blood using LC–MS-MS
Authors: Zhu Rongzhe , Dong Xiaoru , Zhang Dingang , Liu Xiaochen , Ye Yonghong , Jiang Yan 
Published: July 2020

Abstract
The trend for the concomitant prescription of antidepressants and antipsychotics is increasing. This calls for a veracious screening and quantifying method for forensic and clinical use. In this study, a liquid chromatography–tandem mass spectrometry (LC–MS-MS) method was developed and validated for the simultaneous determination and quantification of 38 antidepressants, antipsychotics and relevant metabolites in small volumes (200 μL) of human whole blood. Analytes and deuterated internal standards were extracted using liquid–liquid extraction. The separation, determination and quantification of the analytes were performed using an LC–MS-MS system equipped with an ACQUITY UPLC® BEH Phenyl Column under a positive electrospray ionization mode. After validation, the analytical procedure was proved to be highly sensitive, with a limit of detection ranging from 0.0005 to 1 ng/mL and a lower limit of quantification ranging from 0.002 to 2 ng/mL. Bias and within- and between-run precision were within 14.7% for all analytes. Recoveries were reproducible and those of 35 analytes were &gt;50%. Dilution integrity was evaluated to ensure that the therapeutic and toxic blood concentration ranges of target compounds were fully covered. Finally, this method was applied to authentic whole blood samples collected from two forensic cases, which demonstrated its practical usefulness of providing accurate and comprehensive information concerning the previous medication of the deceased.
Modified Glasgow prognostic score is a pre-surgical prognostic marker of disease mortality in upper urinary tract urothelial carcinoma
Authors: Tsuzuki Shunsuke , Kimura Shoji , Fukuokaya Wataru , Yanagisawa Takafumi , Hata Kenichi , Miki Jun , Kimura Takahiro , Abe Hirokazu , Egawa Shin 
Published: July 2020

AbstractBackgroundTo investigate the prognostic value of pre-surgical modified Glasgow prognostic score in upper urinary tract urothelial carcinoma patients treated with radical nephroureterectomy.MethodsWe retrospectively reviewed the clinical records of 273 urinary tract urothelial carcinoma patients treated with radical nephroureterectomy. The modified Glasgow prognostic score was evaluated based on pre-surgical serum C-reactive protein and albumin. Association of modified Glasgow prognostic score with recurrence-free survival, cancer-specific survival and overall survival rates was estimated using Kaplan−Meier method and log-rank test was used to compare survival outcome. Cox regression analyses were performed for the assessment of the modified Glasgow prognostic score with recurrence-free survival, cancer-specific survival and overall survival.ResultsOf total 273 patients, the modified Glasgow prognostic score 0, 1 and 2 were assigned in 216 (79%), 45 (17%) and 12 (4%), respectively. The recurrence-free survival, cancer-specific survival and overall survival of urinary tract urothelial carcinoma patients with modified Glasgow prognostic score 2 were significantly worse than those with modified Glasgow prognostic score 0. On univariate analysis, modified Glasgow prognostic score 2 was associated with worse recurrence-free survival, cancer-specific survival and overall survival (all P value &lt;0.01). On multivariate analyses, modified Glasgow prognostic score 2 was independently associated with worse cancer-specific survival and overall survival (hazard ratio: 4.73, 95% confidence interval: 1.31–17.2 and hazard ratio: 3.66, 95% confidence interval: 1.08–12.4, respectively). In the subgroup analyses of advanced urinary tract urothelial carcinoma patients, modified Glasgow prognostic score 2 was independently associated with worse recurrence-free survival (hazard ratio 4.31, 95% confidence interval: 1.69–11.1).ConclusionsPre-surgical modified Glasgow prognostic score independently predicts cancer-specific survival and overall survival of urinary tract urothelial carcinoma patients. Assessment of pre-surgical modified Glasgow prognostic score status could help identifying the worse survivor of urinary tract urothelial carcinoma patients.
Oxidative stress induced by piperine leads to apoptosis in Candida albicans
Authors: Thakre Archana , Jadhav Vyankatesh , Kazi Rubina , Shelar Amruta , Patil Rajendra , Kharat Kiran , Zore Gajanan , Karuppayil S Mohan 
Published: July 2020

Abstract

Candida albicans is a member of pathogens with potential drug resistance threat that needs novel chemotherapeutic strategies. Considering the multifarious biological activities including bioenhancer activity, anti-Candida potential of piperine was evaluated against planktonic/biofilm and hyphal growth of C. albicans alone or in combination as a synergistic agent with fluconazole. Piperine inhibits planktonic growth at or less than 15 μg/ml, hyphae induction at 5 μg/ml concentration, and exhibits stage-dependent activity against biofilm growth of a fluconazole-resistant strain of C. albicans (ATCC10231). Though piperine couldn't kill inoculum completely at minimum inhibitory concentration (MIC), it is fungicidal at higher concentrations, as shown in apoptosis assay. FIC index values indicate that piperine exhibits excellent synergistic activity with fluconazole against planktonic (0.123) and biofilm (0.215) growth of an FLC resistant strain. Mode of anti-Candida activity was studied by identifying piperine responsive proteins wherein the abundance of 25 proteins involved in stress response, signal transduction and cell cycle were modulated (22 up and 3 down-regulated) significantly in response to piperine (MIC50). Modulation of the proteins involved suggests that piperine affects membrane integrity leading to oxidative stress followed by cell cycle arrest and apoptosis in C. albicans. Flow cytometry-based mitochondrial membrane potential (MMP), cell cycle and apoptosis assay, as well as real-time quantitative polymerase chain reaction analysis of selected genes, confirms piperine induced oxidative stress (TRR1), cell cycle arrest and apoptosis (CaMCA1). Based on our results, we conclude that piperine inhibits planktonic and difficult-to treat-biofilm growth of C. albicans by affecting membrane integrity thereby inducing oxidative stress and apoptosis.

Lay Abstract
Piperine inhibit Candida albicans growth (planktonic and biofilm) significantly in our study. Piperine exhibits excellent synergistic potential with fluconazole The proteome analysis suggests that piperine induced membrane damage leads to oxidative stress followed by cell cycle arrest and apoptosis.
Inhibition of apoptosis signal-regulating kinase 1 mitigates the pathogenesis of human immunodeficiency virus-associated nephropathy
Authors: Chen Anqun , Xu Jin , Lai Han , D’Agati Vivette D , Guan Tian-Jun , Badal Shawn , Liles John , He John C , Lee Kyung 
Published: July 2020

AbstractBackgroundChronic kidney disease (CKD) is a common cause of morbidity and mortality in human immunodeficiency virus (HIV)-positive individuals. Among the HIV-related kidney diseases, HIV-associated nephropathy (HIVAN) is a rapidly progressive renal disease characterized by collapsing focal glomerulosclerosis (GS), microcystic tubular dilation, interstitial inflammation and fibrosis. Although the incidence of end-stage renal disease due to HIVAN has dramatically decreased with the widespread use of antiretroviral therapy, the prevalence of CKD continues to increase in HIV-positive individuals. Recent studies have highlighted the role of apoptosis signal-regulating kinase 1 (ASK1) in driving kidney disease progression through the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase and selective ASK-1 inhibitor GS-444217 was recently shown to reduce kidney injury and disease progression in various experimental models. Therefore we examined the efficacy of ASK1 antagonism by GS-444217 in the attenuation of HIVAN in Tg26 mice.MethodsGS-444217-supplemented rodent chow was administered in Tg26 mice at 4 weeks of age when mild GS and proteinuria were already established. After 6 weeks of treatment, the kidney function assessment and histological analyses were performed and compared between age- and gender-matched control Tg26 and GS-444217-treated Tg26 mice.ResultsGS-444217 attenuated the development of GS, podocyte loss, tubular injury, interstitial inflammation and renal fibrosis in Tg26 mice. These improvements were accompanied by a marked reduction in albuminuria and improved renal function. Taken together, GS-4442217 attenuated the full spectrum of HIVAN pathology in Tg26 mice.ConclusionsASK1 signaling cascade is central to the development of HIVAN in Tg26 mice. Our results suggest that the select inhibition of ASK1 could be a potential adjunctive therapy for the treatment of HIVAN.
A short review of undergraduate occupational medicine training
Authors: Eu E , Soo M P J , Gan W H 
Published: July 2020

AbstractBackgroundMedical schools worldwide allocate little time and utilize varying formats in the teaching of occupational medicine (OM) to undergraduate medical students.AimsTo identify undergraduate OM teaching formats and highlight key findings in these different methods.MethodsA limited literature search conducted on PubMed and Scopus identified relevant articles published in English and between the years 2009 and 2018. Our inclusion criteria were papers containing the key words (‘occupational medicine’ AND (‘medical students’ OR ‘undergraduate medical’)) OR (‘occupational medicine’ AND (‘training’ OR ‘education’ OR ‘teaching’)) in the title or abstract and those that specifically discussed OM education.ResultsThe literature search yielded 1479 papers. Seven of them fulfilled the inclusion criteria and were reviewed in full. Formats in OM education of undergraduate medical students include, either singly or in combination, the use of case studies, didactic sessions, workplace visits, text-based readings and pro forma.ConclusionsOM education has a very small footprint in most undergraduate medical curricula. The studies show that different teaching formats are utilized, often in combination. Case-based discussions and workplace visits are frequently used with good qualitative results. Text-based readings will serve well to build good foundational knowledge, though there is no conclusive evidence that students will perform better.
Patient Isolation during Infectious Disease Outbreaks: Arguments for Physical Family Presence
Authors: Voo Teck Chuan , Lederman Zohar , Kaur Sharon 
Published: July 2020

Abstract
This article argues that outbreak preparedness and response should implement a ‘family presence’ policy for infected patients in isolation that includes the option of physical visits and care within the isolation facility under some conditions. While such a ‘physical family presence’ (PFP) policy could increase infections during an outbreak and may raise moral dilemmas, we argue that it is ethically justified based on the least infringement principle and the need to minimize the harms and burdens of isolation as a restrictive measure. Categorical prohibition of PFP during the course of an outbreak or epidemic is likely to result in unnecessary harms to patients and families, and violate values such as the moral commitments of families to care for each other. Supporting the option of PFP under particular circumstances, on the other hand, will least infringe these moral considerations. An additional reason for a family presence policy is that it may facilitate voluntary cooperation with isolation and other restrictive measures. We provide an analysis of these considerations for supporting modes of family presence during an outbreak emergency, before defending the riskier option of PFP in the isolation facility from plausible objections and concerns.
An independent search for annual modulation and its significance in ANAIS-112 data
Authors: Krishak Aditi , Desai Shantanu 
Published: July 2020

Abstract
We perform an independent search for sinusoidal-based modulation in the recently released ANAIS-112 data, which could be induced by dark matter scatterings. We then evaluate this hypothesis against the null hypothesis that the data contain only background, using four different model comparison techniques. These include frequentist, Bayesian, and two information theory-based criteria (Akaike and Bayesian information criteria). This analysis was done on both the residual data (by subtracting the exponential fit obtained from the ANAIS-112 Collaboration) as well as the total (non-background subtracted) data. We find that according to the Bayesian model comparison test, the null hypothesis of no modulation is decisively favored over a cosine-based annual modulation for the non-background subtracted dataset in the 2–6 keV energy range. None of the other model comparison tests decisively favor any one hypothesis over another. This is the first application of Bayesian and information theory techniques to test the annual modulation hypothesis in ANAIS-112 data, extending our previous work on the DAMA/LIBRA and COSINE-100 data. Our analysis codes have also been made publicly available.
Parametrized test of parity-violating gravity using GWTC-1 events
Authors: Yamada Kei , Tanaka Takahiro 
Published: July 2020

Abstract
Parity-violating (PV) gravity has recently attracted interest in several aspects. One of them is the axion–graviton coupling to test the axion–dark matter model. Moreover, by extending Chern–Simons (CS) gravity to include derivatives of a scalar field up to the second order, a more general class of PV gravity theory, which we call the CNCL model, has been proposed [M. Crisostomi et al., Phys. Rev. D, 97, 044034 (2018)]. The model can be further extended by including even higher derivatives of the scalar field and/or higher curvature terms.
In this paper, we discuss the effect of parity violation in the gravitational sector on the propagation of gravitational waves from binary coalescence by introducing a model-independent parametrization of modification. Our parametrization includes the CNCL model as well as CS gravity. The effect of parity violation on the gravitational waveform is maximum when the source binary orientation to our line of sight is edge-on, while the modified waveform reduces to the parity-symmetric one when the source is face-on. We perform a search for the signature of such modification by using the LIGO/Virgo O1/O2 catalog. We find that the catalog data is consistent with general relativity and obtain constraints on parity violation in gravity for various post-Newtonian order modifications for the first time. The obtained constraint on CS gravity is consistent with the results in previous works. On the other hand, the constraint on the CNCL model that we obtain is tighter than the previous results by roughly 7 orders of magnitude.
Lessons from mixed-method evaluations—An example from labor market research
Authors: Osiander Christopher 
Published: July 2020

AbstractThis article deals with the following questions: which approaches are suitable for program evaluations in the context of labor market research and why are mixed-method designs often most promising? The strengths and weaknesses of different approaches suggest that summative and formative as well as quantitative and qualitative elements should be combined with each other. We use the case of active labor market policies—an evaluation of qualification measures for the unemployed—as an example to illustrate mixed-method evaluations in research practice. The results of the evaluation show that the scientific gain of the formative part often depends heavily on the careful selection of the ‘right’ persons for expert interviews. The findings can even lead to further research projects that deal with some of the questions raised in the formative part in more detail. The summative part of the evaluation—a quantitative impact analysis—is based on extensive quantitative data sets. It is a methodological innovation to combine survey and administrative micro-data in this particular context. We use propensity score matching to analyze program effects on the participants that are positive and substantial.
Non-radiographic versus radiographic axSpA: what’s in a name?
Authors: Michelena Xabier , López-Medina Clementina , Marzo-Ortega Helena 
Published: July 2020

Abstract
Axial spondyloarthritis is a heterogeneous inflammatory condition with variable clinical presentations and outcomes. The complexity of its diagnosis and absence of biomarkers hamper the development of diagnostic criteria with the risk of misuse of the available classification criteria in clinical practice and its consequences. Axial spondyloarthritis should be regarded as a continuum in which some patients, but not all, will have a more severe phenotype characterized by progression into new bone formation and joint fusion. Growing understanding of the factors that might drive disease progression and treatment response will allow for better characterization of treatment options and outcome for each affected individual. The aim of this review is to update the current evidence of what is axial spondyloarthritis and to highlight the need to focus on the concept rather than its classification.