bluuebunny/crossref_metadata_2025_split huggingface dataset:
IoTScal‐H : Hybrid monitoring solution based on cloud computing for autonomic middleware‐level scalability management within IoT systems and different SLA traffic requirements
Authors: Zyane Abdellah , Bahiri Mohamed Nabil , Ghammaz Abdelilah 
Published: June 2020

SummaryWireless sensor network (WSN) technologies have enabled ubiquitous sensing to intersect many areas of modern day living. The creation of these devices offers the ability to get, gather, exchange, and consume environmental measurement from the physical world in a communicating‐actuating network, called the Internet of Things (IoT). As the number of physical world objects from heterogeneous network environments grows, the data produced by these objects raise uncontrollably, bringing a delicate challenge into scalability management in the IoT networks. Cloud computing is a much more mature technology, offering unlimited virtual capabilities in terms of storage capacity and processing power. Ostensibly, it seems that cloud computing and IoT are evolving independently on their own paths, but in reality, the integration of clouds with IoT will lead to deal with the inability to scale automatically depending on the overload caused by the drastic growth of the number of connected devices and/or by the huge amount of exchanged data in the IoT networks. In this paper, our objective is to promote the scalability management, using hybrid mechanism that will combine traffic‐oriented mechanism and resources‐oriented mechanism, with adaption actions. By the use of autonomic middleware within IoT systems, we seek to improve the monitoring components's architectural design, based on cloud computing‐oriented scalability solution. The intention is to maximize the number of satisfied requests, while maintaining at an acceptable QoS level of the system performances (RTT of the system, RAM, and CPU of the middleware). In order to evaluate our solution performance, we have performed different scenarios testbed experiments. Generally, our proposed results are better than those mentioned as reference.
Genotyping‐free parentage assignment using RAD‐seq reads
Authors: Chen Shi‐Yi , Li Cao , Luo Zhihao , Li Xiaowei , Gan Jia , Jia Xianbo , Lai Song‐Jia , Wang Wei 
Published: June 2020

AbstractParentage assignment is defined as the identification of the true parents of one focal offspring among a list of candidates and has been commonly used in zoological, ecological, and agricultural studies. Although likelihood‐based parentage assignment is the preferred method in most cases, it requires genotyping a predefined set of DNA markers and providing their population allele frequencies. In the present study, we proposed an alternative method of parentage assignment that does not depend on genotype data and prior information of allele frequencies. Our method employs the restriction site‐associated DNA sequencing (RAD‐seq) reads for clustering into the overlapped RAD loci among the compared individuals, following which the likelihood ratio of parentage assignment could be directly calculated using two parameters—the genome heterozygosity and error rate of sequencing reads. This method was validated on one simulated and two real data sets with the accurate assignment of true parents to focal offspring. However, our method could not provide a statistical confidence to conclude that the first ranked candidate is a true parent.
Anaemia, iron deficiency and heart failure in 2020: facts and numbers
Authors: Chopra Vijay K. , Anker Stefan D. 
Published: June 2020

AbstractAnaemia is defined by WHO as Hb < 13.0 g/dL in male adults and <12.0 g/dL in female adults. It is a common comorbidity in patients of heart failure with both HFrEF and HFpEF. The incidence ranges between 30% and 50%, though in certain communities, it is likely to be higher still. Elderly age, severe heart failure, poor nutrition, and elevation of inflammatory markers are associated with a higher incidence of anaemia. However, the commonest contributing factor to anaemia in HF is iron deficiency. In a Canadian study of 12 065 patients, the incidence of absolute ID was 21% in anaemic patients. Many other western studies have also quoted incidences varying between 35% and 43%.The earlier attempts to improve outcomes by supplementation with Erythropoietic‐stimulating factors were unsuccessful and resulted in a higher incidence of thrombotic events. Iron deficiency (ID) has emerged as an important factor in patients of HF, even in those without anaemia and worsens outcomes. It is defined as Ferritin levels below 100 mcg/L or 100–299 μg/L with transferrin saturation of <20%. Attempts to correct ID by oral supplementation have been unsuccessful as seen in IRON‐HF and IRONOUT‐HF trials. FAIR‐HF and CONFIRM‐HF conclusively established the role of IV Iron in improving exercise capacity and quality of life in patients with HFrEF. ESC guidelines have given a class IC indication for testing all heart failure patients for ID, and an IIaA recommendation for its correction by IV ferric carboxymaltose was found to be deficient. Ongoing trials will establish the role of IV iron in improving mortality and in HFpEF patients and in patients with acute heart failure.
Left ventricular midwall fibrosis as a predictor of sudden cardiac death in non‐ischaemic dilated cardiomyopathy: a meta‐analysis
Authors: Wang Jie , Yang Fuyao , Wan Ke , Mui David , Han Yuchi , Chen Yucheng 
Published: June 2020

AbstractIdentification of patients with non‐ischaemic dilated cardiomyopathy (NICM) who are at risk of sudden cardiac death (SCD) and could benefit from an implantable cardioverter defibrillator (ICD) is challenging. The study aims to systematically assess the prognostic value of left ventricular (LV) midwall late gadolinium enhancement (LGE) pattern in patients with NICM and further explore its value on predicting SCD events. The study was prospectively registered in PROPSERO (CRD42019138468). We systematically searched PubMed, Ovid Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov to identify studies that evaluated the association between LV midwall LGE and clinical outcomes (all‐cause mortality, cardiovascular mortality, and SCD or aborted SCD endpoint) in NICM patients. A meta‐analysis was performed to determine pooled odds ratio (OR) for these adverse events. Seven studies including 1827 NICM patients over a mean follow‐up duration of 36.1 ± 19.3 months were included. The presence of LV midwall LGE pattern was observed in 562 (30.8%) patients. The pooled OR was 3.37 [95% confidence intervals (CIs): 1.35–8.42] for all‐cause mortality, 5.56 (95% CI: 1.23–25.22) for cardiovascular mortality, and 2.25 (95% CI: 1.16–3.16) for SCD or aborted SCD. In a subgroup analysis with mean ejection fraction cut‐off point of 35%, the pooled OR for SCD or aborted SCD was 2.06 (95% CI: 1.32–3.22) for LV ejection fraction (LVEF) > 35% and 2.49 (95% CI: 1.48–4.20) for LVEF ≤ 35%. In addition, our study indicated that LV midwall LGE showed an excellent negative predictive value in identifying high‐risk NICM patients and that the number needed to treat with ICD implantation in NICM patients with midwall LGE is 7. The presence of LV midwall on LGE is a significant prognosticator of adverse events in NICM patients. Additionally, patients with LV midwall LGE may be considered for ICD therapy irrespective of LVEF.
The effects of longitudinal variations in valley geometry and wood load on flood response
Authors: Hinshaw Sarah , Wohl Ellen , Davis Dany 
Published: June 2020

AbstractWe use field measurements and airborne LiDAR data to quantify the potential effects of valley geometry and large wood on channel erosional and depositional response to a large flood (estimated 150‐year recurrence interval) in 2011 along a mountain stream. Topographic data along 3 km of Biscuit Brook in the Catskill Mountains, New York, USA reveal repeated downstream alternations between steep, narrow bedrock reaches and alluvial reaches that retain large wood, with wood loads as high as 1261 m3 ha−1. We hypothesized that, within alluvial reaches, geomorphic response to the flood, in the form of changes in bed elevation, net volume of sediment eroded or aggraded, and grain size, correlates with wood load. We hypothesized that greater wood load corresponds to lower modelled average velocity and less channel‐bed erosion during the flood, and finer median bed grain size and a lower gradation coefficient of bed sediment. The results partly support this hypothesis. Wood results in lower reach‐average modelled velocity for the 2011 flood, but the magnitude of change in channel‐bed elevation after the 2011 flood among alluvial and bedrock reaches does not correlate with wood load. Wood load does correlate with changes in sediment volume and bed substrate, with finer grain size and smaller sediment gradation in reaches with more wood. The proportion of wood in jams is a stronger predictor of bed grain‐size characteristics than is total wood load. We also see evidence of a threshold: greater wood load correlates with channel aggradation at wood loads exceeding approximately 200 m3 ha−1. In this mountain stream, abundant large wood in channel reaches with alluvial substrate creates lower velocity that results in finer bed material and, when wood load exceeds a threshold, reach scale increases in aggradation. This suggests that reintroducing small amounts of wood or one logjam for river restoration will have limited geomorphic effects. © 2020 John Wiley & Sons, Ltd.
Attenuating the Epidermal Growth Factor Receptor–Extracellular Signal‐Regulated Kinase–Sex‐Determining Region Y‐Box 9 Axis Promotes Liver Progenitor Cell‐Mediated Liver Regeneration in Zebrafish
Authors: So Juhoon , Kim Minwook , Lee Seung‐Hoon , Ko Sungjin , Lee Daniel A. , Park Hyewon , Azuma Mizuki , Parsons Michael J. , Prober David , Shin Donghun 
Published: June 2020

Background and Aims
The liver is a highly regenerative organ, but its regenerative capacity is compromised in severe liver injury settings. In chronic liver diseases, the number of liver progenitor cells (LPCs) correlates proportionally to disease severity, implying that their inefficient differentiation into hepatocytes exacerbates the disease. Moreover, LPCs secrete proinflammatory cytokines; thus, their prolonged presence worsens inflammation and induces fibrosis. Promoting LPC‐to‐hepatocyte differentiation in patients with advanced liver disease, for whom liver transplantation is currently the only therapeutic option, may be a feasible clinical approach because such promotion generates more functional hepatocytes and concomitantly reduces inflammation and fibrosis.

Approach and Results
Here, using zebrafish models of LPC‐mediated liver regeneration, we present a proof of principle of such therapeutics by demonstrating a role for the epidermal growth factor receptor (EGFR) signaling pathway in differentiation of LPCs into hepatocytes. We found that suppression of EGFR signaling promoted LPC‐to‐hepatocyte differentiation through the mitogen‐activated ERK kinase (MEK)‐extracellular signal‐regulated kinase (ERK)–sex‐determining region Y‐box 9 (SOX9) cascade. Pharmacological inhibition of EGFR or MEK/ERK promoted LPC‐to‐hepatocyte differentiation as well as genetic suppression of the EGFR‐ERK‐SOX9 axis. Moreover, Sox9b overexpression in LPCs blocked their differentiation into hepatocytes. In the zebrafish liver injury model, both hepatocytes and biliary epithelial cells contributed to LPCs. EGFR inhibition promoted the differentiation of LPCs regardless of their origin. Notably, short‐term treatment with EGFR inhibitors resulted in better liver recovery over the long term.

Conclusions
The EGFR‐ERK‐SOX9 axis suppresses LPC‐to‐hepatocyte differentiation during LPC‐mediated liver regeneration. We suggest EGFR inhibitors as a proregenerative therapeutic drug for patients with advanced liver disease.
Type 2 Diabetes: A Risk Factor for Hospital Readmissions and Mortality in Australian Patients With Cirrhosis
Authors: Ahn Sang Bong , Powell Elizabeth E. , Russell Anthony , Hartel Gunter , Irvine Katharine M. , Moser Chris , Valery Patricia C. 
Published: June 2020

Although there is evidence that type 2 diabetes mellitus (T2D) impacts adversely on liver‐related mortality, its influence on hospital readmissions and development of complications in patients with cirrhosis, particularly in alcohol‐related cirrhosis (the most common etiological factor among Australian hospital admissions for cirrhosis) has not been well studied. This study aimed to investigate the association between T2D and liver cirrhosis in a population‐based cohort of patients admitted for cirrhosis in the state of Queensland, Australia. A retrospective cohort analysis was conducted using data from the Queensland Hospital Admitted Patient Data Collection, which contains information on all hospital episodes of care for patients with liver cirrhosis, and the Death Registry during 2008‐2017. We used demographic, clinical data, and socioeconomic characteristics. A total of 8,631 patients were analyzed. A higher proportion of patients with T2D had cryptogenic cirrhosis (42.4% vs. 27.3%, respectively; P < 0.001) or nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (13.8% vs. 3.4%, respectively; P < 0.001) and an admission for hepatocellular carcinoma (18.0% vs. 12.2%, respectively; P < 0.001) compared to patients without T2D. Patients with liver cirrhosis with T2D compared to those without T2D had a significantly increased median length of hospital stay (6 [range, 1‐11] vs. 5 [range, 1‐11] days, respectively; P < 0.001), double the rate of noncirrhosis‐related admissions (incidence rate ratios [IRR], 2.03; 95% confidence interval [CI], 1.98‐2.07), a 1.35‐fold increased rate of cirrhosis‐related admissions (IRR, 1.35; 95% CI, 1.30‐1.41), and significantly lower survival (P < 0.001). Conclusion: Among hospitalized patients with cirrhosis, the cohort with T2D is at higher risk and may benefit from attention to comorbidities and additional support to reduce readmissions.
The impact of COVID‐19 lockdown on admission to gynecological emergency departments: Results from a multicenter Italian study
Authors: Grandi Giovanni , Del Savio Maria C. , Caroli Martina , Capobianco Giampiero , Dessole Francesco , Tupponi Giulio , Petrillo Marco , Succu Claudia , Paoletti Anna M. , Facchinetti Fabio 
Published: June 2020

AbstractObjectiveTo evaluate the impact of the COVID‐19 lockdown on admissions to gynecological emergency departments (ED) of three Italian university hospitals with different rates of COVID‐19 incidence.MethodsA retrospective study was conducted in the gynecological EDs of Modena (Emilia‐Romagna), Sassari and Cagliari (Sardinia) regarding all admissions to gynecological EDs during November 1 to 30, 2019, and March 11 to April 9, 2020 (lockdown period).ResultsA total of 691 women (mean age 38.3 ± 14.3 years) who were admitted to the gynecological EDs were included. The relative decrease in women evaluated from March 11 to April 9, 2020, was −56.6% (95% confidence interval [CI] 52.2–61.1). Time spent in the ED was also significantly shorter during this period (P=0.02) in comparison to November 1 to 30, 2019. The most evident decrease was observed for pelvic pain (−68.9% [95% CI 60.3–76.7]; −91 cases). The management of women suggests a more effective use of the ED, with higher rates of hospitalization (P=0.001) and recourse to emergent surgeries (P=0.005) and lower rates of discharge to home (P=0.03).ConclusionThe COVID‐19 lockdown greatly reduced the rate of admission to gynecological EDs, but the real emergencies were filtered from the more deferrable ones.
The prenatal maternal representations of mothers at risk of recurrent care proceedings in the Family Drug and Alcohol Court: A thematic analysis
Authors: Meier Jasmin , Edginton Elizabeth 
Published: June 2020

AbstractBackgroundA substantial number of birth mothers experience repeat removals of their infants and children due to child protection concerns. The perspectives of mothers going through repeat removals and their experiences of pregnancy are insufficiently researched.Aims and methodsThe current qualitative study aimed to explore the maternal representations of five pregnant mothers at risk of recurrent care proceedings. A thematic analysis of these mothers’ responses to the Pregnancy Interview focused on their representations of themselves as mothers, of their babies, and of the mother–baby relationship.ResultsSeven key themes were identified: (1a) “Uncertainty and fear of losing the baby,” (1b) “Uncertainty but hope of becoming a mother,” (2) “Not wanting to be like their own mother,” (3) “Experiencing recovery and pregnancy as two interdependent processes,” (4) “Struggling to imagine the baby,” (5) “The omnipresence of previous children,” (6) “Pleasure at starting to have a connection with the baby,” and (7) “Noting the baby's dependency.”ConclusionThe results are clinically relevant as they highlight grief, maternal self‐identity, recovery from substance abuse, and ability to manage uncertainty as critical areas of intervention for these mothers.
Cognitive evolutionary therapy versus standard cognitive therapy for depression: A single‐blinded randomized clinical trial
Authors: Giosan Cezar , Cobeanu Oana , Wyka Katarzyna , Muresan Vlad , Mogoase Cristina , Szentagotai Aurora , Malta Loretta S. , Moldovan Ramona 
Published: June 2020

AbstractObjectiveTo compare the efficacy of cognitive evolutionary therapy (CET) with cognitive therapy (CT) for depression.MethodsNinety‐seven participants (78 females/19 males) were randomized to a single‐blinded controlled trial (CET:n = 51 vs. CT:n = 46). Assessments were conducted at baseline, Sessions 4 and 8, posttreatment, and 3‐month follow‐up. Clinical diagnoses were made with Structured Clinical Interview for DSM‐IV (SCID) and self‐reports for depression and secondary outcomes.ResultsAlthough both groups showed significant reductions in depressive symptomatology, the overall Time × Treatment group interaction in the intent to treat analysis was not significant (p = .770, posttreatment:d = 0.39). However, CET was superior to CT at increasing engagement in social and enjoyable activities (p = .040, posttreatment:d = 0.83,p = .040) and showed greater reductions than the CT group in behavioral inhibition/avoidance (p = .047,d = 0.62). The between‐group differences generally diminished at the 3‐month follow‐up.ConclusionsCET is a novel therapy for depression that may add therapeutic benefits beyond those of CT.
Clinical features of scrupulosity: Associated symptoms and comorbidity
Authors: Siev Jedidiah , Rasmussen Jessica , Sullivan Alexandra D. W. , Wilhelm Sabine 
Published: June 2020

AbstractObjectiveScrupulosity is a manifestation of obsessive‐compulsive disorder (OCD) characterized by religious or moral core fears. Clinicians often struggle to treat scrupulosity, which may be associated with several features known to predict poor treatment outcome. The purpose of this study was to examine these features in participants with scrupulous OCD, contamination OCD, and healthy controls.MethodA total of 68 participants (57.4% women, agemean = 34.01) completed diagnostic interviews, and measures of symptoms and quality‐of‐life.ResultsRelative to comparison groups, scrupulous participants had higher rates of obsessive‐compulsive personality disorder, more severe schizotypal symptoms, and more severe symptoms of depression. In addition, OCD severity was strongly associated with poor insight in the scrupulous group. Both OCD groups reported poorer quality of life than did healthy controls.ConclusionsClinicians working with scrupulous individuals may enhance the efficacy of treatment in this challenging population by assessing carefully for these features, and incorporating treatment elements that address them.
MiRNA‐145‐5p prevents differentiation of oligodendrocyte progenitor cells by regulating expression of myelin gene regulatory factor
Authors: Kornfeld Samantha F. , Cummings Sarah E. , Fathi Samaneh , Bonin Sawyer R. , Kothary Rashmi 
Published: June 2020

AbstractThe roles of specific microRNAs (miRNA) in oligodendrocyte (OL) differentiation have been studied in depth. However, miRNAs in OL precursors and oligodendrocyte progenitor cells (OPCs) have been less extensively investigated. MiR‐145‐5p is highly expressed in OPCs relative to differentiating OLs, suggesting this miRNA may serve a function specifically in OPCs. Knockdown of miR‐145‐5p in primary OPCs led to spontaneous differentiation, as evidenced by an increased proportion of MAG+ cells, increased cell ramification, and upregulation of multiple myelin genes including MYRF, TPPP, and MAG, and OL cell cycle exit marker Cdkn1c. Supporting this transition to a differentiating state, proliferation was reduced in miR‐145‐5p knockdown OPCs. Further, knockdown of miR‐145‐5p in differentiating OLs showed enhanced differentiation, with increased branching, myelin membrane production, and myelin gene expression. We identified several OL‐specific genes targeted by miR‐145‐5p that exhibited upregulation with miR‐145‐5p knockdown, including myelin gene regulatory factor (MYRF), that could be regulating the prodifferentiation phenotype in both miR‐145 knockdown OPCs and OLs. Indeed, spontaneous differentiation with knockdown of miR‐145‐5p was fully rescued by concurrent knockdown of MYRF. However, proliferation rate was only partially rescued with MYRF knockdown, and overexpression of miR‐145‐5p in OPCs increased proliferation rate without affecting expression of already lowly expressed differentiation genes. Taken together, these data suggest that in OPCs miR‐145‐5p both prevents differentiation at least in part by preventing expression of MYRF and promotes proliferation via as‐yet‐unidentified mechanisms. These findings clarify the need for differential regulation of miR‐145‐5p between OPCs and OLs and may have further implications in demyelinating diseases such as multiple sclerosis where miR‐145‐5p is dysregulated.
Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension
Authors: Chen Jingyuan , Luo Jun , Yang Xiaojie , Ouyang Minzhi , Zhu Tengteng , Li Yuanchang , Luo Peng , Chen Yusi , Li Zilu , Li Jiang 
Published: June 2020

AbstractRight heart failure and right ventricular (RV) remodeling were the main reason for mortality of pulmonary hypertension (PH) patients. Apolipoprotein AV (ApoA5) is a key regulator of plasma triglyceride and have multifunction in several target organs. We detected decreased ApoA5 in serum of patients with PH and both in serum and RV of monocrotaline‐induced PH model. Exogenously, overexpression ApoA5 by adenovirus showed protective effects on RV failure and RV fibrosis secondary to PH. In addition, in vitro experiments showed ApoA5 attenuated the activation of fibroblast induced by transforming growth factor β1 and synthesis and secretion of extracellular matrix by inhibiting focal adhesion kinase‐c‐Jun N‐terminal kinase‐Smad3 pathway. Finally, we suggest that ApoA5 may potentially be a pivotal target for RV failure and fibrosis secondary of PH.