bluuebunny/crossref_metadata_2025_split huggingface dataset:
[18F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer
Authors: Dietlein Felix , Mueller Peter , Kobe Carsten , Endepols Heike , Hohberg Melanie , Zlatopolskiy Boris D. , Krapf Philipp , Heidenreich Axel , Neumaier Bernd , Drzezga Alexander , Dietlein Markus 
Published: October 2020

Abstract
Purpose
PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [18F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemical recurrence. In this retrospective study, we evaluated the performance of [18F]-JK-PSMA-7 under ADT.

Procedures
We examined the performance of [18F]-JK-PSMA-7 in 70 patients (first cohort) with increasing or detectable PSA values under ADT (PSA < 2 ng/ml for 21/70 patients). We further analyzed 58 independent patients with PSA levels < 2 ng/ml under ADT, who were imaged with [68Ga]PSMA-11 or [18F]DCFPyL (second cohort). Finally, we compared detection rates between [18F]-JK-PSMA-7, [68Ga]PSMA-11, and [18F]DCFPyL.

Results
In the first cohort, we detected [18F]-JK-PSMA-7-positive lesions in 63/70 patients. In patients with PSA levels ≥ 2 ng/ml, the detection rate was 100 % (49/49). In patients with PSA < 2 ng/ml, the detection rate was significantly lower (66.7 %, 14/21, p = 9.7 × 10−5) and dropped from 85.7 % (12/14, PSA levels between 0.3 and 2.0 ng/ml) to 28.6 % (2/7) for PSA levels < 0.3 ng/ml (p = 1.73 × 10−2). In the second cohort (PSA < 2 ng/ml), the detection rate was 79.3 % (46/58) for [68Ga]PSMA-11 or [18F]DCFPyL. Again, the detection rate was significantly higher (p = 1.1 × 10−2) for patients with PSA levels between 0.3 and 2.0 ng/ml (87.0 %, 40/46) relative to those with PSA levels < 0.3 ng/ml (50 %, 6/12). No significant difference was found between [18F]-JK-PSMA-7 and [68Ga]PSMA-11 or [18F]DCFPyL in patients with PSA levels < 2 ng/ml (p = 0.4295).

Conclusion
[18F]-JK-PSMA-7 PET showed a high detection rate in patients with PSA levels ≥ 0.3 ng/ml under ADT. The lower PSA threshold of 0.3 ng/ml for high detection rates was consistent across the three PSMA ligands. Thus, PSMA imaging is suitable for clinical follow-up of patients with increasing PSA levels under ADT.
Disruptive Innovation and Moral Uncertainty
Authors: Nickel Philip J. 
Published: October 2020

AbstractThis paper develops a philosophical account of moral disruption. According to Robert Baker, moral disruption is a process in which technological innovations undermine established moral norms without clearly leading to a new set of norms. Here I analyze this process in terms of moral uncertainty, formulating a philosophical account with two variants. On the harm account, such uncertainty is always harmful because it blocks our knowledge of our own and others’ moral obligations. On the qualified harm account, there is no harm in cases where moral uncertainty is related to innovation that is “for the best” in historical perspective or where uncertainty is the expression of a deliberative virtue. The two accounts are compared by applying them to Baker’s historical case of the introduction of mechanical ventilation and organ transplantation technologies, as well as the present-day case of mass data practices in the health domain.
Estimation of Selected Minerals in Aortic Aneurysms—Impaired Ratio of Zinc to Lead May Predispose?
Authors: Socha Katarzyna , Karwowska Alicja , Kurianiuk Adam , Markiewicz-Żukowska Renata , Guzowski Andrzej , Gacko Marek , Hirnle Tomasz , Borawska Maria H. 
Published: October 2020

AbstractThe objective of this study was to estimate the content of copper, zinc, selenium, cadmium, and lead in the tissue of patients with aortic aneurysms. Molar ratio of Cu/Zn and antioxidant micronutrients to toxic elements was also calculated. A total of 108 patients: 47 with abdominal aortic aneurysm (AAA), 61 patients with thoracic aortic aneurysm (TAA), and a control group of 20 abdominal aortic (AA) and 20 thoracic aortic (TA) wall samples from the deceased were studied. The concentrations of mineral components in the tissue samples were determined by the AAS method. The average concentration of Cu in the aortic wall of patients with TAA was significantly lower than in the aortic wall samples of healthy people. The mean concentration of Zn in the aortic wall of patients with AAA and TAA was significantly lower than in the control group samples. Cu/Zn ratio was significantly higher in AAA patients than in control group which indicates a greater role of oxidative stress and inflammatory process in this type of aneurysm. The concentration of Se was significantly decreased in TAA patients compared with the control group; in turn, the concentration of Pb was increased in this group of patients. We observed significantly lower Cu/Pb ratio in TAA patients than in control group, whereas Zn/Pb ratio was significantly lower comparing with control samples in both types of aneurysms. In the examined aneurysms, we have shown the differences in concentrations of mineral components compared with the control tissues. The Zn concentration was decreased in both AAA and TAA samples. Impaired ratio of Zn to Pb may predispose to aortic aneurysms.
Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder
Authors: Li Qianqian , Yan Jun , Liao Jinmin , Zhang Xiao , Liu Lijun , Fu Xiaoyu , Tan Hao Yang , Zhang Dai , Yan Hao 
Published: October 2020

AbstractStress might exaggerate the compulsion and impair the working memory of patients with obsessive-compulsive disorder (OCD). This study evaluated the effect of stress on the cognitive neural processing of working memory in OCD and its clinical significance using a “number calculation working memory” task. Thirty-eight patients and 55 gender- and education-matched healthy controls were examined. Stress impaired the performance of the manipulation task in patients. Healthy controls showed less engagement of the medial prefrontal cortex and striatum during the task under stress versus less stress, which was absent in the patients with OCD. The diagnosis × stress interaction effect was significant in the right fusiform, supplementary motor area, precentral cortex and caudate. The failure of suppression of the medial prefrontal cortex and striatum and stress-related hyperactivation in the right fusiform, supplementary motor area, precentral cortex, and caudate might be an OCD-related psychopathological and neural response to stress.
The Glycocalyx and Pressure-Dependent Transcellular Albumin Transport
Authors: Dull Randal O. , Chignalia Andreia Z. 
Published: October 2020

Abstract
Purpose
Acute increases in hydrostatic pressure activate endothelial signaling pathways that modulate barrier function and vascular permeability. We investigated the role the glycocalyx and established mechanotransduction pathways in pressure-induced albumin transport across rat lung microvascular endothelial cells.

Methods
Rat lung microvascular endothelial cells (RLMEC) were cultured on Costar Snapwell chambers. Cell morphology was assessed using silver nitrate staining. RLMEC were exposed to zero pressure (Control) or 30 cmH2O (Pressure) for 30 or 60 min. Intracellular albumin uptake and transcellular albumin transport was quantified. Transcellular transport was reported as solute flux (Js) and an effective permeability coefficient (Pe). The removal of cell surface heparan sulfates (heparinase), inhibition of NOS (L-NAME) and reactive oxygen species (apocynin, Apo) was investigated.

Results
Acute increase in hydrostatic pressure augmented albumin uptake by 30–40% at 60 min and Js and Pe both increased significantly. Heparinase increased albumin uptake but attenuated transcellular transport while L-NAME attenuated both pressure-dependent albumin uptake and transport. Apo interrupted albumin uptake under both control and pressure conditions, leading to a near total lack of transcellular transport, suggesting a different mechanism and/or site of action.

Conclusion
Pressure-dependent albumin uptake and transcellular transport is another component of endothelial mechanotransduction and associated regulation of solute flux. This novel albumin uptake and transport pathway is regulated by heparan sulfates and eNOS. Albumin uptake is sensitive to ROS. The physiological and clinical implications of this albumin transport are discussed.
First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”
Authors: Jakob Carolin E. M. , Borgmann Stefan , Duygu Fazilet , Behrends Uta , Hower Martin , Merle Uta , Friedrichs Anette , Tometten Lukas , Hanses Frank , Jung Norma , Rieg Siegbert , Wille Kai , Grüner Beate , Klinker Hartwig , Gersbacher-Runge Nicole , Hellwig Kerstin , Eberwein Lukas , Dolff Sebastian , Rauschning Dominic , von Bergwelt-Baildon Michael , Lanznaster Julia , Strauß Richard , Trauth Janina , de With Katja , Ruethrich Maria , Lueck Catherina , Nattermann Jacob , Tscharntke Lene , Pilgram Lisa , Fuhrmann Sandra , Classen Annika , Stecher Melanie , Schons Maximilian , Spinner Christoph , Vehreschild Jörg Janne 
Published: October 2020

Abstract
Purpose
Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19.

Methods
Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models.

Results
We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66–85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46–65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25–2.42, p = 0.001; 66–85 years: aOR 1.93, 95% CI 1.36–2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49–3.81, p < 0.001 vs. individuals aged 26–45 years], male sex (aOR 1.23, 95% CI 1.01–1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09–1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04–1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis.

Conclusion
The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.
Coronavirus disease 2019 and sudden sensorineural hearing loss
Authors: Lang B , Hintze J , Conlon B 
Published: October 2020

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 emerged in December 2019 in Wuhan, China, and was declared a global health emergency of international concern by the World Health Organization on 30th January 2020. It has resulted in almost 600 000 deaths to date worldwide. Sudden sensorineural hearing loss is a known complication of a number of viral infections, but there is little in the literature to date on its association with coronavirus disease 2019.Case reportThis paper presents the case of a 30-year-old female staff nurse who contracted coronavirus disease 2019 and presented to our department with a significant unilateral sensorineural hearing loss confirmed on audiogram. She was treated with a course of oral steroids, but unfortunately there was no improvement in her hearing.ConclusionThis case report is important as it highlights the importance of having a low index of suspicion when patients present with a variety of symptoms not previously associated with coronavirus disease 2019. The paper also discusses the controversy surrounding the use of steroids in the management of this disease.
Human Rights in the Seventy-Fifth Year of the UN
Authors: Ramcharan Bertrand 
Published: October 2020

AbstractAs part of the special issue on “The United Nations at Seventy-Five: Looking Back to Look Forward,” this essay looks at the UN's human rights efforts through the lens of the ethics of survival, normative ethics, the ethics of protection, institutional ethics, and the ethics of the human predicament in the face of the Sustainable Development Goals (SDGs). The essay finds that while the consecration of the right to life has made a contribution to the ethics of human survival, the overall impact of the human rights program has been marginal. Normative ethics shows the UN performing magisterially in drafting and adopting a body of international norms for the universal protection of human rights. However, when it comes to the ethics of protection, the UN performs poorly because of the numerous oppressive governments that control the world body. On the ethics of the human predicament, this essay finds that SDG 16, which is devoted to development, peace, justice, and strong institutions, has so far had little practical impact. Gross violations of human rights continue to take place in numerous parts of the world.
Determinants of dietary and physical activity behaviours among women of reproductive age in urban Uganda, a qualitative study
Authors: Yiga Peter , Ogwok Patrick , Achieng Julian , Auma Mary Devota , Seghers Jan , Matthys Christophe 
Published: October 2020

AbstractObjective:To explore determinants of dietary and physical activity behaviours among women of reproductive age.Design:Data were collected through focus group discussions (FGD). The FGD guide was based on a modified theoretical framework; theory of planned behaviour was incorporated with constructs of health belief model, precaution adoption process model, social cognitive and social support theory. Discussions were audio recorded, transcribed verbatim and analysed thematically.Setting:Kampala, Uganda.Participants:Women were categorised into young adults; 18–34 years and adults; 35–45 yearsResults:Separate FGD with independent participants were conducted for dietary and physical activity behaviours until data saturation was achieved. Six FGD were conducted per behaviour. Determinants of dietary behaviours at intra-individual level included gaps in food skills, knowledge and self-efficacy, food safety concerns, convenience, finances and physiological satisfaction. The social-cultural norms were relationship between vegetable consumption and low social status, consideration of fruits as a snack for children and not food and habitual orientation towards carbohydrate foods. At environment level, social networks and increased availability of energy-dense, nutrient poor, street and processed foods influence dietary behaviour. For physical activity, intra-individual determinants were knowledge gaps and self-efficacy, while socio-cultural norms included gender stereotypes. Home (limited space and sedentary entertainment like social media and TV) and physical environment (cheap motorised transportation) influence physical activity.Conclusion:The existing cultural beliefs promote dietary and physical activity behaviours which are divergent from healthy recommendations. Therefore, a comprehensive intervention is needed to address socio-cultural misconceptions, financial and time limitations in urban Uganda.
The Great (Toilet) Paper Chase: Our Study of the 1979 San Francisco Bay Sewage Spill (As Motivated by Walter Cronkite and the CBS Evening News)
Authors: Oremland Ronald S. , Cloern James E. 
Published: October 2020

AbstractEarth system science is boundless. There are no limits to the kinds of questions, problems, mysteries, or paradoxes that motivate our research and shape its direction. So how do we decide which directions to take, which questions to answer, what problems to solve? Sometimes our research is motivated by an unanticipated event requiring a degree of stochastic interpretive crystal ball gazing. Last year we ended our careers of more than four decades as life scientists at the USGS in Menlo Park, CA. We find ourselves in a state of reflection and want to share a story about a stochastic event that brought us together as collaborators, taught us essential lessons of life as research scientists, and seeded a friendship that endures.
Photonuclear Reactions in Lightning: 1. Verification and Modeling of Reaction and Propagation Processes
Authors: Wada Y. , Enoto T. , Nakazawa K. , Odaka H. , Furuta Y. , Tsuchiya H. 
Published: October 2020

AbstractWe report simulation results of photonuclear reactions in the atmosphere triggered by a downward terrestrial gamma ray flash in lightning. Possible channels of reactions in the atmosphere and their cross‐sections are verified with the ENDF/B‐VII.1 library. Monte Carlo simulations with two stages are then performed with the Geant4 framework. In the first stage, electrons following the relativistic runaway electron avalanche spectrum are produced in a mass model of the atmosphere, and production of photoneutrons and β+‐decay nuclei is calculated based on the nuclear data library. In total 1 × 1013 neutrons and 4 × 1012 β+‐decay nuclei are produced by 1018 energetic electrons above 1 MeV. In the second stage, propagation of the photoneutrons and positrons from the β+‐decay nuclei in the previous stage is calculated. As a result, we model on‐ground distributions of fluxes and energy spectra for neutrons, neutron‐related gamma rays, and annihilation ones. The simulation model is to be compared with photonuclear events detected in low‐charge‐center winter thunderstorms.
Resolving the Latitudinal Short‐Scale Gravity Field of Jupiter Using Slepian Functions
Authors: Parisi Marzia , Galanti Eli , Folkner William M. , Kaspi Yohai , Buccino Dustin R. 
Published: October 2020

AbstractEarly gravity measurements performed by the Juno spacecraft determined Jupiter's low‐degree gravity harmonics, including the first estimate of the planet's north‐south asymmetric field. The retrieved information was used to infer that the strong zonal winds visible at the cloud tops must extend down a few thousand kilometers, where they are suppressed in the deep interior. The next frontier for the Juno gravity experiment includes, among other goals, the determination of Jupiter's small‐scale gravity field with high accuracy, and its relation to atmospheric circulation at shorter length scales. The geometry of the Juno closest approaches to the planet poses a challenge to this task, as they span latitudes between 4°N and 29°N over the course of the nominal mission. Since Doppler measurements are the most sensitive to gravity anomalies when the spacecraft is close to the body, observations of Jupiter's gravity field are mostly concentrated in the northern hemisphere, while the traditional spherical harmonic functions are not orthonormal over a latitudinal subdomain. Here we define customized Slepian functions, which are orthogonal in a specific latitude range and are optimized to represent Jupiter's local surface gravity at north latitudes. We show that with the new functions, the short‐scale latitudinal variability of the gravity field is resolved with high accuracy between 15°S and 45°N latitude. Furthermore, preliminary results show that the estimated values for the Slepian coefficients from the Juno data match the predictions obtained using thermal wind balance to relate the dynamical density anomalies and the winds with an optimized scale height.
Secondary research use of personal medical data: attitudes from patient and population surveys in The Netherlands and Germany
Authors: Richter Gesine , Borzikowsky Christoph , Lesch Wiebke , Semler Sebastian C. , Bunnik Eline M. , Buyx Alena , Krawczak Michael 
Published: October 2020

AbstractMaking routine clinical-care-data available for medical research requires adequate consent to legitimize use and exchange. While, public interest in supporting medical research is increasing, individuals often find it difficult to actively enable researchers to access their data. In addition to broad consent, the idea of (consent-free) data donation has been brought into play as another way to legitimize secondary research use of medial data. However, flanking the implementation of broad consent policies or data donation, the attitude of patients, and the general public toward different aspects of these approaches needs to be assessed. We conducted two empirical studies to this end among Dutch patients (n = 7430) and representative German citizens (n = 1006). Wide acceptance of broad consent was observed among Dutch patients (92.3%), corroborating previous findings among German patients (93.0%). Moreover, 28.8% of the Dutch patients generally approved secondary data-use for non-academic research, 42.3% would make their decision dependent upon the type of institution in question. In the German survey addressing the general population, 78.8% approved data donation without explicit consent as an alternative model of legitimization, the majority of those who approved (96.7%) would allow donated data to be used by universities and public research institutions. This willingness to support contrasted sharply with the fact that only 16.6% would allow access to the data by industry. Our findings thus not only add empirical evidence to the debate about broad consent and data donation, but also suggest that widespread public discussion and education about the role of industry in medical research is necessary in that context.
Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers
Authors: Ozdas Mehmet S. , Shah Aagam S. , Johnson Paul M. , Patel Nisheet , Marks Markus , Yasar Tansel Baran , Stalder Urs , Bigler Laurent , von der Behrens Wolfger , Sirsi Shashank R. , Yanik Mehmet Fatih 
Published: October 2020

AbstractNon-invasive, molecularly-specific, focal modulation of brain circuits with low off-target effects can lead to breakthroughs in treatments of brain disorders. We systemically inject engineered ultrasound-controllable drug carriers and subsequently apply a novel two-component Aggregation and Uncaging Focused Ultrasound Sequence (AU-FUS) at the desired targets inside the brain. The first sequence aggregates drug carriers with millimeter-precision by orders of magnitude. The second sequence uncages the carrier’s cargo locally to achieve high target specificity without compromising the blood-brain barrier (BBB). Upon release from the carriers, drugs locally cross the intact BBB. We show circuit-specific manipulation of sensory signaling in motor cortex in rats by locally concentrating and releasing a GABAA receptor agonist from ultrasound-controlled carriers. Our approach uses orders of magnitude (1300x) less drug than is otherwise required by systemic injection and requires very low ultrasound pressures (20-fold below FDA safety limits for diagnostic imaging). We show that the BBB remains intact using passive cavitation detection (PCD), MRI-contrast agents and, importantly, also by sensitive fluorescent dye extravasation and immunohistochemistry.