bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent progress on biomass‐derived ecomaterials toward advanced rechargeable lithium batteries
Authors: Liu Jia , Yuan Hong , Tao Xinyong , Liang Yeru , Yang Seung Jae , Huang Jia‐Qi , Yuan Tong‐Qi , Titirici Maria‐Magdalena , Zhang Qiang 
Published: February 2020

AbstractBiomass materials are of great interest in high‐energy rechargeable batteries due to their appealing merits of sustainability, environmental benefits, and more importantly, structural/compositional versatilities, abundant functional groups and many other unique physicochemical properties. In this perspective, we provide both overview and prospect on the contributions of biomass‐derived ecomaterials to battery component engineering including binders, separators, polymer electrolytes, electrode hosts, and functional interlayers, and so forth toward high‐stable lithium–ion batteries, lithium–sulfur batteries, lithium–oxygen batteries, and solid state lithium metal batteries. Furthermore, based on the multifunctionalities of bio‐based materials, the design protocols for battery components with desired properties are highlighted. This perspective affords fresh inspiration on the rational designs of biomass‐based materials for advanced lithium‐based batteries, as well as the sustainable development of advanced energy storage devices.image
Synthesis and odour evaluation of double‐bond isomers of DAMASCENOLIDE, 4‐(4‐methylpent‐3‐en‐1‐yl)‐2(5H)‐furanone, which has a citrus‐like odour
Authors: Miyazawa Yamato , Ohashi Teruhisa , Kawaguchi Kenji , Tanaka Naoko , Katsuta Ryo , Yajima Arata , Nukada Tomoo , Ishigami Ken 
Published: February 2020

AbstractOur group recently isolated 4‐(4‐methylpent‐3‐en‐1‐yl)‐2(5H)‐furanone (DAMASCENOLIDE or MPF), which has a citrus‐like odour, from damask rose (Rosa damascena). DAMASCENOLIDE has two double bonds, and we were interested in how the position and the geometric isomerism of these double bonds change the odour. Therefore, we synthesized eleven novel double‐bond isomers of DAMASCENOLIDE and evaluated their odours. Some of them have similar odours to DAMASCENOLIDE, while many others have different odours such as metallic, tropical and fishy. Especially, a Z‐form double‐bond moiety changed the odour significantly. Regarding the odour intensity, compounds with 2(3H)‐furanone skeleton tend to be stronger than compounds with 2(5H)‐furanone skeleton. From these results, it was found that the position and the geometric isomerism of the double bond greatly affected the odour.
Advantages and detection of phase coding in the absence of rhythmicity
Authors: Bush Daniel , Burgess Neil 
Published: February 2020

AbstractThe encoding of information in spike phase relative to local field potential (LFP) oscillations offers several theoretical advantages over equivalent firing rate codes. One notable example is provided by place and grid cells in the rodent hippocampal formation, which exhibit phase precession—firing at progressively earlier phases of the 6–12 Hz movement‐related theta rhythm as their spatial firing fields are traversed. It is often assumed that such phase coding relies on a high amplitude baseline oscillation with relatively constant frequency. However, sustained oscillations with fixed frequency are generally absent in LFP and spike train recordings from the human brain. Hence, we examine phase coding relative to LFP signals with broadband low‐frequency (2–20 Hz) power but without regular rhythmicity. We simulate a population of grid cells that exhibit phase precession against a baseline oscillation recorded from depth electrodes in human hippocampus. We show that this allows grid cell firing patterns to multiplex information about location, running speed and movement direction, alongside an arbitrary fourth variable encoded in LFP frequency. This is of particular importance given recent demonstrations that movement direction, which is essential for path integration, cannot be recovered from head direction cell firing rates. In addition, we investigate how firing phase might reduce errors in decoded location, including those arising from differences in firing rate across grid fields. Finally, we describe analytical methods that can identify phase coding in the absence of high amplitude LFP oscillations with approximately constant frequency, as in single unit recordings from the human brain and consistent with recent data from the flying bat. We note that these methods could also be used to detect phase coding outside of the spatial domain, and that multi‐unit activity can substitute for the LFP signal. In summary, we demonstrate that the computational advantages offered by phase coding are not contingent on, and can be detected without, regular rhythmicity in neural activity.
Examining Moments of Possibility Toward College Readiness in a Literacy‐and‐Songwriting Initiative
Authors: Marciano Joanne E. , Watson Vaughn W.M. , Beymer Alecia , Deroo Matthew R. 
Published: February 2020

AbstractThe authors examined how middle and high school students participating in a literacy‐and‐songwriting initiative in Detroit, Michigan, experienced moments of possibility that supported the youth in envisioning themselves as college bound. The authors explain how they drew from culturally relevant and sustaining educational approaches to design literacy instruction for youth of color that built from students’ interests as strengths, challenging educational disparities related to college readiness and access. The authors describe three workshops that they facilitated with youth participants, examine and share examples of multimodal artifacts generated by youth participants during the workshops, and provide recommendations for adolescent and adult literacy educators seeking to enact similar approaches for supporting students’ college readiness in their own work.
A feasibility study of OCT for anatomical and vascular phenotyping of mouse embryo
Authors: Choi Woo J. , Maga A. M. , Kim Eun S. , Wang Ruikang K. 
Published: February 2020

AbstractThe embryo phenotyping of genetic murine model is invaluable when investigating functions of genes underlying embryonic development and birth defect. Although traditional imaging technologies such as ultrasound are very useful for evaluating phenotype of murine embryos, the use of advanced techniques for phenotyping is desirable to obtain more information from genetic research. This letter tests the feasibility of optical coherence tomography (OCT) as a high‐throughput phenotyping tool for murine embryos. Three‐dimensional OCT imaging is performed for live and cleared mouse embryos in the late developmental stage (embryonic day 17.5). By using a dynamic focusing method and OCT angiography (OCTA) approach, our OCT imaging of the embryo exhibits rapid and clean visualization of organ structures deeper than 5 mm and complex microvasculature of perfused blood vessels in the murine embryonic body. This demonstration suggests that OCT imaging can be useful for comprehensively assessing embryo anatomy and angiography of genetically engineered mice.
Circular RNA (circ‐0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3
Authors: Zhao Wenbo , Wang Shuai , Qin Tingyu , Wang Wenzhan 
Published: February 2020

AbstractIt is growingly recognized that messenger RNAs (mRNAs) are important regulators of various cancers. However, there are few reporters about the function of E2F3 in retinoblastoma (RB), which needs more exploration. In addition, the circRNA circ‐0075804 was derived from the E2F3 host gene. The purpose of the study is to figure out the role and molecular regulation mechanism of E2F3 and circ‐0075804 in RB. The role of E2F3 in RB was determined through E2F3 silencing and loss of expression was evaluated by real‐time quantitative polymerase chain reaction (RT‐qPCR), Western blot, CCK‐8, colony formation, and 5‐ethynyl‐2′‐deoxyuridine assays. The interactions between E2F3 and circ‐0075804 were validated through loss and gain function of circ‐0075804. Besides, the role of circ‐0075804 in RB was determined by several functional assays. And the binding ability between heterogeneous nuclear ribonucleoprotein K and circ‐0075804 was verified by RNA pull‐down, Western blot, and RT‐qPCR assays. The expression of E2F3 was upregulated in RB cell lines. Furthermore, knockdown of E2F3 inhibited cell proliferation and induced cell apoptosis in RB. And circ‐0075804 positively regulated the expression of E2F3. Moreover, circ‐0075804 facilitated cell proliferation and suppressed cell apoptosis. Besides, HNRNPK could bind with circ‐0075804 in RB. Finally, knockdown of E2F3 partly rescued the promoting role of circ‐0075804 overexpression in RB. Overall, circ‐0075804 promotes the proliferation of RB via combining HNRNPK to improve the stability of E2F3, which brings new light for treating RB.
STAT1‐induced upregulation of lncRNA RHPN1‐AS1 predicts a poor prognosis of hepatocellular carcinoma and contributes to tumor progression via the miR‐485/CDCA5 axis
Authors: Zhang Xiaozhan , Yan Zhenzhen , Wang Lei , Zhang Shijie , Gao Ming 
Published: February 2020

AbstractLong noncoding RNAs (lncRNAs) act as a critical regulator in tumor progression, but few lncRNAs have been functionally characterized in hepatocellular carcinoma (HCC). Using The Cancer Genome Atlas datasets and bioinformatic technology, we screened and identified a novel HCC‐related lncRNA, RHPN1 antisense RNA 1 (RHPN1‐AS1). We found that the levels of RHPN1‐AS1 were distinctly upregulated in both HCC tissues and cell lines. RHPN1‐AS1 was activated by the transcription factor STAT1. Clinical investigations suggested that higher levels of RHPN1‐AS1 were distinctly correlated with histologic grade, advanced tumor, node, metastasis stage, and poorer clinical prognosis. Multivariate assays identified high RHPN1‐AS1 expression as an unfavorable prognostic biomarker for patients with HCC. Functional study revealed that knockdown of RHPN1‐AS1 was able to suppress cells proliferation and metastasis, and promote cell apoptosis. Further mechanistic investigation suggested that RHPN1‐AS1 could promote CDCA5 expressions by functioning as a competing endogenous RNA for miR‐485. This interaction resulted in consequentially suppression of HCC cells proliferation, migration, and invasion. Our findings for the first time illustrate how RHPN1‐AS1 displayed its tumor‐promotive roles in HCC and may offer a new biomarker and a potential therapeutic target for patients with HCC.
Prevalence of liver disease in Colombia between 2009 and 2016
Authors: Bejarano Ramírez Diana Fernanda , Carrasquilla Gutiérrez Gabriel , Porras Ramírez Alexandra , Vera Torres Alonso 
Published: February 2020

AbstractBackground and AimLiver disease refers to a set of pathologies resulting from the interruption of liver function or the poor functioning of the liver. The estimation of morbidity and mortality due to liver disease and the context in which the disease develops are determining factors for public policies related to liver disease and its causes. The primary etiologies are cirrhosis and hepatocellular carcinoma, which are directly related to hepatitis B and C virus and alcohol consumption. Followed by hepatotoxic drug use, autoimmune hepatitis, cholestatic diseases, genetic abnormalities, and nonalcoholic steatohepatitis.MethodsA descriptive cross‐sectional study was conducted to estimate the prevalence of liver disease in Colombia between 2009 and 2016. Using the Data Warehouse–Cube of SISPRO as the primary source of the data, prevalence proportions were calculated and adjusted according to the Bennett Horiuchi method. The relationship with alcohol consumption and the index of unsatisfied basic needs based on estimates from 2005 were considered as sociodemographic variables.ResultsThe prevalence of liver disease differs with regard to the type of illness, sex and age of the patient, access to medical attention, and geographical location.ConclusionsAs liver disease is a public health problem, it requires early intervention such as raising awareness and prevention strategies, along with postdiagnosis care channels for treatment, rehabilitation, and palliation. By implementing these strategies, public health will be positively impacted, health care resources will be optimized, and more productive years of life are available for the citizens of the country.
Synthesis of amide‐linked benzazolyl isoxazoles adopting green methods and evaluation as antimicrobials
Authors: Sowdari Jyothi , Thata Sreenivasulu , Gudi Yamini , Venkatapuram Padmavathi , Adivireddy Padmaja 
Published: February 2020

AbstractSome new benzoxazolyl isoxazoles, benzothiazolyl isoxazoles and benzimidazolyl isoxazoles connected by amide bonds (7‐9) were prepared from N‐benzazolylcarbamoylmethylcinnamamides (1‐3) adopting eco‐friendly synthetic methodologies. In fact, cycloaddition of nitrile oxide generated from araldoxime using iodosobenzene and cetyltrimethylammonium bromide to 1‐3 followed by treatment with iodine in dimethyl sulfoxide led to the formation of title compounds with good yields and in shorter reaction times. The structures of all the synthesized compounds were confirmed by spectral parameters, viz, IR, NMR, and mass spectra and were assayed for antimicrobial activity. Among all the tested compounds, 8a and 8c displayed excellent antibacterial activity, whereas 9a and 9c showed promising antifungal activity.
HIV pre‐exposure prophylaxis for female sex workers: ensuring women’s family planning needs are not left behind
Authors: Bowring Anna L , Ampt Frances H , Schwartz Sheree , Stoové Mark A , Luchters Stanley , Baral Stefan , Hellard Margaret 
Published: February 2020

AbstractIntroductionFemale sex workers (FSWs) experience overlapping burdens of HIV, sexually transmitted infections and unintended pregnancy. Pre‐exposure prophylaxis (PrEP) is highly efficacious for HIV prevention. It represents a promising strategy to reduce HIV acquisition risks among FSWs specifically given complex social and structural factors that challenge consistent condom use. However, the potential impact on unintended pregnancy has garnered little attention. We discuss the potential concerns and opportunities for PrEP to positively or negatively impact the sexual and reproductive health and rights (SRHR) of FSWs.DiscussionFSWs have high unmet need for effective contraception and unintended pregnancy is common in low‐ and middle‐income countries. Unintended pregnancy can have enduring health and social effects for FSWs, including consequences of unsafe abortion and financial impacts affecting subsequent risk‐taking. It is possible that PrEP could negatively impact condom and other contraceptive use among FSWs due to condom substitution, normalization, external pressures or PrEP provision by single‐focus services. There are limited empirical data available to assess the impact of PrEP on pregnancy rates in real‐life settings. However, pregnancy rates are relatively high in PrEP trials and modelling suggests a potential two‐fold increase in condomless sex among FSWs on PrEP, which, given low use of non‐barrier contraceptive methods, would increase rates of unintended pregnancy. Opportunities for integrating family planning with PrEP and HIV services may circumvent these concerns and support improved SRHR. Synergies between PrEP and family planning could promote uptake and maintenance for both interventions. Integrating family planning into FSW‐focused community‐based HIV services is likely to be the most effective model for improving access to non‐barrier contraception among FSWs. However, barriers to integration, such as provider skills and training and funding mechanisms, need to be addressed.ConclusionsAs PrEP is scaled up among FSWs, there is growing impetus to consider integrating family planning services with PrEP delivery in order to better meet the diverse SRHR needs of FSWs and to prevent unintended consequences. Programme monitoring combined with research can close data gaps and mobilize adequate resources to deliver comprehensive SRHR services respectful of all women’s rights.
Multiparametric Magnetic Resonance Imaging for the Diagnosis and Differential Diagnosis of Parotid Gland Tumors
Authors: Gökçe Erkan 
Published: February 2020

The majority of salivary gland tumors occur in the parotid glands. Characterization (ie, benign or malignant, and histological type), location (deep or superficial), and invasion into the neighboring tissues of parotid tumors determine preoperative treatment planning. MRI gives more information than other imaging methods about the internal structure, localization, and relationship with other tissues of parotid tumors. Functional MRI methods (diffusion‐weighted imaging, dynamic contrast‐enhanced MRI, perfusion‐weighted MRI, MR spectroscopy, etc.) have been increasingly used recently to increase the power of radiologists to characterize the tumors. Although they increase the workload of radiologists, the combined use of functional MRI methods improves accuracy in the differentiation of the tumors. There are a wide range of studies in the literature dealing with the combined use of different functional imaging methods in combination with conventional sequences. The aim of the present review is to evaluate conventional and functional/advanced MR methods, as well as multiparametric MRI applications combining them in the diagnosis of parotid gland tumors.Evidence Level: 5Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2020;52:11–32.
Intensification of historical drought over China based on a multi‐model drought index
Authors: Han Xinyi , Wu Jianjun , Zhou Hongkui , Liu Leizhen , Yang Jianhua , Shen Qiu , Wu Junbin 
Published: February 2020

AbstractObservations show that in recent decades, a large area of China has been affected by drought and that frequent droughts have caused damage to the ecological environment and the economy. Because of the differences in data and methods, assessing regional droughts often leads to contradictory conclusions of trending. The self‐calibrated Palmer drought severity index (scPDSI) is based on multiple parameters, and it is considered regionally applicable and is widely used. However, some divergence has been observed in the results of drought in China using different scPDSI_PM (scPDSI based on the Penman–Monteith model) datasets. We establish an integrated scPDSI dataset (scPDSI_PM_INT) by averaging three scPDSI products and analyse the temporal change and spatial characteristics of drought in China from 1950 to 2009. The annual and seasonal drought intensities have increased slightly in the past 60 years, while the disturbed area has broadened significantly, especially in eastern China which has become much drier than before. The drought intensity of most drought‐prone regions is slight and moderate, while severe and extreme droughts occur mostly in the Agro‐Pastoral Transitional Zone and the Beijing–Tianjin–Hebei Region.
Improved in‐solution trypsin digestion method for methanol–chloroform precipitated cellular proteomics sample
Authors: Shahinuzzaman A. D. A. , Chakrabarty Jayanta K. , Fang Zixiang , Smith David , Kamal Abu Hena Mostafa , Chowdhury Saiful M. 
Published: February 2020

AbstractMethanol–chloroform based protein precipitation is an essential step in many liquid chromatography–tandem mass spectrometry‐based cellular proteomics applications. However, re‐solubilization of the total protein precipitate is difficult using regular in‐solution digestion protocol. Sodium deoxycholate is reported as an efficient surfactant for re‐solubilization of membrane fractions. In this study, we demonstrated an application combining methanol–chloroform based protein precipitations and deoxycholic acid assisted re‐solubilization of pellets to evaluate the improvement of protein identifications in mass spectrometry‐based bottom‐up proteomics. We evaluated the modified method using an equal amount of Raw 264.7 mouse macrophage cell lysate. Detailed in‐solution trypsin digestion studies were presented on methanol–chloroform precipitated samples with or without deoxycholic acid treatments and compared with popular sample digestion methods. A mass spectrometric analysis confirmed an 82% increase in protein identification in deoxycholic acid‐treated samples compared to other established methods. Furthermore, liquid chromatography–tandem mass spectrometry analysis of an equal amount of proteins from methanol–chloroform precipitated, and methanol–chloroform/deoxycholic acid‐treated macrophage cell lysate showed a 14% increase and 27% unique protein identifications. We believe this improved digestion method could be a complementary or alternative method for mammalian cell sample preparations where sodium dodecyl sulfate based lysis buffer is frequently used.
Posttraumatic Growth After MDMA‐Assisted Psychotherapy for Posttraumatic Stress Disorder
Authors: Gorman Ingmar , Belser Alexander B. , Jerome Lisa , Hennigan Colin , Shechet Ben , Hamilton Scott , Yazar‐Klosinski Berra , Emerson Amy , Feduccia Allison A. 
Published: February 2020

Abstract3,4‐Methylenedioxymethamphetamine (MDMA)–assisted psychotherapy for posttraumatic stress disorder (PTSD) has been shown to significantly reduce clinical symptomatology, but posttraumatic growth (PTG), which consists of positive changes in self‐perception, interpersonal relationships, or philosophy of life, has not been studied with this treatment. Participant data (n = 60) were pooled from three Phase 2 clinical studies employing triple‐blind crossover designs. Participants were required to meet DSM‐IV‐R criteria for PTSD with a score higher than 50 on the Clinician‐Administered PTSD Scale (CAPS‐IV) as well as previous inadequate response to pharmacological and/or psychotherapeutic treatment. Data were aggregated into two groups: an active MDMA dose group (75–125 mg of MDMA; n = 45) or placebo/active control (0–40 mg of MDMA; n = 15). Measures included the Posttraumatic Growth Inventory (PTGI) and the CAPS‐IV, which were administered at baseline, primary endpoint, treatment exit, and 12‐month follow‐up. At primary endpoint, the MDMA group demonstrated more PTG, Hedges’ g = 1.14, 95% CI [0.49, 1.78], p < .001; and a larger reduction in PTSD symptom severity, Hedges’ g = 0.88, 95% CI [−0.28, 1.50], p < .001, relative to the control group. Relative to baseline, at the 12‐month follow‐up, within‐subject PTG was higher, p < .001; PTSD symptom severity scores were lower, p < .001; and two‐thirds of participants (67.2%) no longer met criteria for PTSD. MDMA‐assisted psychotherapy for PTSD resulted in PTG and clinical symptom reductions of large‐magnitude effect sizes. Results suggest that PTG may provide a new mechanism of action warranting further study.
Reasons Why Pregnant Women Participate in Ultrasound Research Involving Transvaginal Scans
Authors: Meagher Barbara T. , Campos Marissa R. , Thornton Patrick , Klima Carrie , Peters Tara A. , Hallberg Josefin , Ulfhager Emma , O'Brien William D. , McFarlin Barbara L. 
Published: February 2020

ObjectivesThe aim of this study was to explore the motivations of pregnant women in participating in an ultrasound study and the acceptability of vaginal ultrasound examinations.MethodsA prospective sample of 270 women were asked one question: “Can you tell me what motivated you to participate in the study?” The data were then analyzed through a qualitative thematic analysis with an inductive approach. In addition to the thematic analysis, quantification of the data was performed to enhance the qualitative result.ResultsThrough the thematic analysis, 5 themes emerged from the responses of the participants: altruism, research, personal experience, personal benefit, and finding out. All responses were relatively short, and some responses included more than one theme.ConclusionsVaginal ultrasound examinations were acceptable to the participants, and pregnant women had many motivations to participate. Regardless of race, ethnicity, or insurance status, the women in our study were altruistic and curious about our research.