bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of massage on the quality of life in patients recovering from COVID-19
Authors: Wu Liu , Dong Yuting , Li Jin , Huang Ju , Wen Dengpeng , Peng Tao , Luo Jian 
Published: June 2020

Abstract

Background:
There is a worldwide outbreak of covid-19, and as the number of patients increases, more and more patients are recovering. Massage is used as an alternative therapy. Currently, there are no relevant articles for systematic review.

Methods:
We will search the randomized controlled trials related to acupuncture therapy and postoperative anorectal diseases from inception to January 2020. The following database is our focus area: the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wan-Fang Database. All published randomized controlled trials in English or Chinese related to massage for COVID-19 will be included. Primary outcome asthe influence of massage on the quality of life of convalescent patients. Secondary outcomes were accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, clinical curative effect, and improved quality of life.

Results:
The results will provide a high-quality synthesis of current evidence for researchers in this subject area.

Conclusion:
The conclusion of our study will provide evidence to judge whether massage is an effective intervention on the quality of life in patients recovering.

PROSPERO registration number:
CRD42020181398
Association of the interaction between the rs9619311 and rs402007 polymorphisms and smoking with essential hypertension in Chinese Han population
Authors: Chen Chao , Yang Ming , Dou Li-Ping , Ling Dong-Ming , Huang Shuwei 
Published: June 2020

Abstract

Background:
To assess the association of the interaction between the rs9619311 and rs402007 polymorphisms and smoking with essential hypertension (EH) in a Chinese Han population.

Method:
Peripheral blood samples were extracted from 422 EH patients and 280 normotensive (NT) patients in a Chinese Han population. A whole blood genomic DNA extraction kit was used to extract genomic DNA from the blood samples. Polymerase chain reaction restriction fragment length polymorphism was used to detect the rs402007 polymorphism of a disintegrin and metalloproteinase with thrombospondin type motifs 1 gene and the rs9619311 polymorphism of the tissue inhibitor of metalloproteinase-3 gene. The distributions of the genotypes and alleles between the 2 study groups (EH and NT) were compared. The main risk factors for EH were determined by using logistic regression analysis. The effects of gene-gene and gene-smoking interactions on EH were analyzed using multifactor dimensional reduction.

Results:
The frequencies of the rs402007 GC + CC genotype and the C allele were significantly different between the EH and NT groups (0.68 vs 0.57, χ
2 = 8.99a, P = .003, odds ratio [OR] = 1.19; 0.45 vs 0.32, χ
2 = 22.16a, P < .001, OR = 1.38). The frequencies of the rs9619311 TC + CC genotype and the C allele were also significantly different between the 2 groups (0.33 vs 0.25, χ
2 = 4.51a, P = .04, OR = 1.44; 0.18 vs 0.13, χ
2 = 7.03a, P = .01, OR = 1.50). Logistic regression analysis suggests that the rs402007 and rs9619311 polymorphisms are independent risk factors for EH (OR = 2.37, 1.86; P < .001, respectively). The multifactor dimensionality redundant analysis results showed that the interaction among rs402007, rs9619311, and smoking was statistically significant (P = .001).

Conclusions:
A disintegrin and metalloproteinase with thrombospondin type motifs 1 rs402007 and tissue inhibitor of metalloproteinase-3 rs9619311 polymorphisms are associated with EH in a Chinese Han population, and there was a positive interaction among rs402007, rs9619311, and smoking.
Metabolic syndrome, depression, and fibromyalgia syndrome prevalence in patients with irritable bowel syndrome
Authors: Bayrak Muharrem 
Published: June 2020

Abstract
Although both metabolic syndrome (MetS) and irritable bowel syndrome (IBS) have been linked with altered gut microbiota, only a few studies investigated the association between them. Hence, we aimed to evaluate the prevalence of MetS along with depression and fibromyalgia syndrome (FMS) in IBS patients.
This was a case-control study in which 3808 consecutive patients who attended outpatient clinics of Erzurum Regional Training and Research Hospital between May 2019 and August 2019 were evaluated in terms of IBS with Rome-IV criteria. Out of 486 patients who were diagnosed as IBS, 176 patients were excluded for various reasons. Control subjects were randomly selected from IBS-negative subjects. MetS was diagnosed based on International Diabetes Federation criteria. Depression, anxiety disorder, and FMS were assessed via Hamilton Depression Scale, Beck Anxiety Inventory, and American College of Rheumatology criteria, respectively. Blood samples were obtained to measure biochemical parameters.
Study group included 310 IBS patients, and control group included 304 subjects. The prevalence of the MetS was significantly higher among IBS patients compared with controls (36.8% vs 21.7%, respectively, P = .006). The rate of obesity was 18.1% among IBS subjects, and 10.2% in the controls. The prevalence of fibromyalgia (30% vs 3%, respectively, P < .001), anxiety-disorder (39.7% vs 10.2%, P < .001) and depression (8.1% vs 4.9%, P < .001) were significantly higher in IBS group than controls.
Metabolic syndrome and obesity were significantly more frequent in IBS patients compared with controls. FMS, anxiety disorder, and depression were also more common among IBS patients.
The epidemiological characteristics of 2019 novel coronavirus diseases (COVID-19) in Jingmen, Hubei, China
Authors: Gao Qijun , Hu Yingfu , Dai Zhiguo , Xiao Feng , Wang Jing , Wu Jing 
Published: June 2020

Abstract
There is currently a global outbreak of coronavirus disease 2019 (COVID-19), and its epidemic characteristics in the areas where the outbreak has been successfully controlled are rarely reported.
Describe the epidemic characteristics of COVID-19 in Jingmen, Hubei, introduce the local prevention and control experience, and observe the impact of various prevention and control measures on the number of new cases.
All the COVID-19 patients diagnosed in the municipal districts of Jingmen from January 12 to February 29, 2020 were enrolled in this study. We described epidemiological data and observed the impact of control measures on the epidemic.
Of the 219 cases (110 men and 109 women), 88 (40%) had exposure to Wuhan. The median age was 48 years (range, 2–88 years; IQR, 35–60). Thirty-three severe patients with a median age of 66 years (range, 33–82 years, IQR, 57–76) were treated in intensive care units; out of these patients, 66.7% (22) were men and 19 (57.5%) had chronic diseases, including hypertension, diabetes, heart failure, stroke, and renal insufficiency. Under the control measures, the number of new patients gradually decreased and nearly disappeared after 18 days. Wearing masks in all kinds of situations prevents most infections and is one of the most effective prevention and control measures.
In conclusion, all people are susceptible to COVID-19, and older males and those with comorbid conditions are more likely to become severe cases. Even though COVID-19 is highly contagious, control measures have proven to be very effective, particularly wearing masks, which could prevent most infections.
Characteristics and long-term outcomes of perineal endometriosis
Authors: Liu Yu , Pi Ruyu , Luo Hong , Wang Wei , Zhao Xia , Qi Xiaorong 
Published: June 2020

Abstract
To summarize the clinical features, diagnosis, and treatments of perineal endometriosis (PEM).
We retrospectively studied the clinical data of 35 patients with PEM between April 2012 and December 2018 in West China Second Hospital. Patients were divided into the gonadotropins releasing hormone (GnRH) agonist group and non-GnRH agonist group.
The main clinical symptom was vulvar painful swellings related to menstrual cycles. Thirty-three patients’ lesions (94.29%) were on the episiotomy scar while 1 case was at the opposite side of the scar. We even found 1 nullipara was diagnosed as PEM. Ten patients (28.57%) were found with anal sphincter involvement. All patients received complete excision of PEM. The recurrence rate of GnRH agonist group was 7.69% (1/13), while the rate of non-GnRH agonist group was 18.75% (3/16).
Most PEM was associated with episiotomy history, but PEM could also exist in nullipara. Complete excision of PEM was inevitable. The effect of GnRH agonist on recurrence of PEM needs further studies.
The effect of age distribution on the prognosis of retroperitoneal neuroblastoma
Authors: Liu Xiaoyan , Zhao Jichun , Zhang Lin , Huang Jing , Ma Yukui 
Published: June 2020

Abstract
Retroperitoneal neuroblastoma is a rare subtype of neuroblastoma and the role of age in its clinical prognosis is still unknown.
To describe the age distribution and investigate the association between age and survival outcomes in patients diagnosed with retroperitoneal neuroblastoma.
We retrospectively analyzed patients registered for retroperitoneal neuroblastoma in the Surveillance, Epidemiology, and End Results (SEER) national database from 1973 to 2015. Age distribution was described and Cox proportional hazard regression was used to evaluate the measured effect of age on overall survival and disease-specific survival.
A total of 399 retroperitoneal neuroblastoma patients with a median follow-up of 53.0 (interquartile range 17.0–133.5) months were included. We found a unimodal distribution of age with a median age of diagnosis to be 1.0 (interquartile range 0.0–4.0) years. Univariate analysis suggested that transformed age was associated with an increased risk of total death and disease-specific death (OR = 4.2, 95% CI 3.0–5.9; OR = 4.7, 95% CI 3.2–6.8). Adjusted smoothed plots showed a nonlinear correlation between age and disease-specific death. The risk of disease-specific death did not increase sharply as the age increased until reaching the inflection point (age < 3 years, OR = 0.4, 95% CI 0.2–1.0; age ≥ 3 years, OR = 1.2, 95% CI 0.9–1.5). There was, however, a linear relationship between age and total deaths (OR = 1.0, 95% CI 0.7–1.2). Adjusted multivariate Cox regression analysis showed that ages ≥ 3 years were associated with a significant increased risks of disease-specific death and total death (OR = 2.5, 95% CI 1.7–3.8; OR = 2.3, 95% CI 1.6–3.3, respectively).
There was a unimodal age distribution of retroperitoneal neuroblastoma usually presented in infants or younger child. Older age was associated with a lower chance of overall survival and the risk of disease-specific death increased sharply after 3 years of age.
Effect of video-guided educational intervention on school engagement of adolescent students with hearing impairment
Authors: Asogwa Uche D. , Ofoegbu Theresa Onyema , Ogbonna Chimaobi Samuel , Eskay Michael , Obiyo Ngozi O. , Nji Godfrey C. , Ngwoke Oliver Rotachukwu , Eseadi Chiedu , Agboti Christian Iheanacho , Uwakwe Chinedozie , Eze Benedict C. 
Published: June 2020

Abstract

Background/objective:
Hearing impaired students still face stigmatization and marginalization especially in inclusive classrooms in developing regions. This negatively impacts their school engagement. The present study aimed at ascertaining the effect of video-guided educational intervention on school engagement of hearing impaired students.

Method:
Randomized controlled trial design was adopted for the present study. A total of 46 junior secondary school students with hearing impairment and low school engagement symptoms participated in this study. The students were randomly assigned to groups – intervention group and care-as-usual control group. A video-guided educational intervention package which consists of 13-minutes captioned video clips with school engagement themes served as the treatment intervention. Data were collected at 3 different times (pre-test, post-test and follow up) using School Engagement Scale created by Fredericks, Blumenfeld, Friedel and Paris (2005). Data were analyzed using independent sample t-test, paired sample t-test, Cohen d and Chi-square.

Results:
Results showed that the video-guided educational intervention significantly improved school engagement level among hearing impaired adolescent students in the intervention group in comparison with the students in the care-as-usual control group as measured by the Student Engagement Scale [Behavioral: t(24) = −9.305, P
< .001; Emotional: t(24) = −7.772, P < .001; Cognitive: t(24) = −7.330 P
< .001) as well as total student engagement (t(24) = 12.022, P < .001, Δ = 5.362). Also, the students who took part in the video-guided educational intervention maintained improved school engagement at follow-up.

Conclusion:
Video-guided educational intervention is an effective intervention for improving school engagement of hearing impaired adolescent students. Since acquiring relevant education is essential for leading a quality life especially among the special needs population, it was recommended that students with hearing impairment should be helped to acquire life skills through education by fostering their school engagement.
The Warburg Effect Promotes Mitochondrial Injury Regulated by Uncoupling Protein-2 in Septic Acute Kidney Injury
Authors: Ji Ran , Chen Weiwei , Wang Yuming , Gong Fangchen , Huang Shunwei , Zhong Ming , Liu Zhaojun , Chen Ying , Ma Li , Yang Zhitao , Qu Hongping , Mao Enqiang , Chen Erzhen 
Published: June 2020

ABSTRACT

Background:
Evidence implying that metabolism reprogramming plays an important role in the regulation of sepsis is increasing; however, whether it has a similar role in septic organ dysfunction remains unclear. Here, we provide evidence to support a new role of uncoupling protein-2 (UCP2)-regulated Warburg effect, i.e., aerobic glycolysis, in promoting mitochondrial injury in the kidney.

Methods:
To imitate sepsis condition, male C57BL/6 mice were operated by the cecal ligation puncture in vivo, whereas a normal human kidney cell line (HK-2) was treated with lipopolysaccharide in vitro. UCP2 small interfering RNA pretreatment was performed to knock down UCP2 expression in vitro. The glycolysis metabolite was detected by liquid chromatography/tandem mass spectrometry in vivo and detected by commercial kits in vitro. Oxidative phosphorylation level and glycolysis level were monitored by measuring the oxygen consumption rate (indicative of respiration) and extracellular acidification rate (indicative of glycolysis) in vitro. Exogenous lactate was supplied to stimulate HK-2 cells and indicators of mitochondrial dysfunction were also assessed.

Results:
Aerobic glycolysis is enhanced in septic tubular epithelial cells, and the glycolysis inhibitor 2-deoxyglucose can partially restore mitochondrial membrane potential and decrease the reactive oxygen species production. With the knockdown of UCP2, the aerobic glycolysis level upregulates, and mitochondrial injury increases.

Conclusions:
These results provide insights on a new mechanism of metabolic regulation of mitochondrial injury and the importance of targeting aerobic glycolysis for the treatment of septic acute kidney injury.
Hypnagogic Frontal EEG Bursts in Children: Epileptic or Not?
Authors: Datta Anita N. 
Published: June 2020

Purpose:
Various EEG patterns emerge in drowsiness. Intermittent bilateral midfrontal slowing (BFS) and hypnogogic frontal predominant sharply contoured waveforms (HFSC), maximal at (Fz, F3-4, and Fp1-2), are often encountered. These do not meet the criteria for epileptiform discharges. The study objective was to determine the clinical significance of BFS and HFSC.

Methods:
Clinical information of children with BFS (n = 49) and HFSC (n = 99) was compared with control subjects with generalized spike-wave (GSW) discharges (n = 102) and normal EEGs (n = 100).

Results:
HFSC was present in younger children (mean age was 3.5 ± 3.6 years), whereas BFS was present in older children (mean 12.9 ± 4.8 years). Seizures occurred in the normal EEG, BFS, HFSC, and GSW groups, respectively, as follows: 22 (22%), 15 (31%), 42 (43%), and 100 (98%) patients, whereas epilepsy occurred in 17 (17%), 10 (20%), 35 (35%), and 95 (93%) patients. The GSW group had more seizures and epilepsy than the other groups (P < 0.001), but the HFSC group also had more seizures (P < 0.001) and epilepsy (P < 0.003) than the normal EEG group. Seizures and neurodevelopmental and psychiatric comorbidities were similar between the BFS and normal EEG groups. Notably, the HFSC group had more developmental delay than the normal EEG group [33 (33%) versus 18 (18%), P < 0.009] but were similar to the GSW group 22 (22%).

Conclusions:
Bilateral midfrontal slowing and HFSC have had unclear significance. Our results suggest that HFSC may be a marker of increased risk of seizure, epilepsy, and developmental delay as compared to children with normal EEGs and has similar risk of developmental delay to those with GSW.
Calibrating an Epidemic Compartment Model to Seroprevalence Survey Data
Authors: Halem Michael 
Published: June 2020

AbstractTo date, the Covid-19 epidemic has produced tremendous cost and harm. However, to date, many epidemic models are not calibrated to seroprevalence survey(s). This paper calibrates a relatively simple, SIR plus confirmed cases (“SIRX”) model against seroprevalence survey data released by the State of New York. The intention of this paper is to demonstrate a potentially new technique of calibration for epidemic models used by scientists, public health officials and governments. The technique can then be incorporated in other more complex models. Open source code is included to assist model developers.
Smoking behaviour in Swiss schoolchildren: the LuftiBus in the school survey
Authors: Mozun Rebeca , Ardura-Garcia Cristina , de Jong Carmen C. M. , Goutaki Myrofora , Usemann Jakob , Singer Florian , Latzin Philipp , Kuehni Claudia E. , Moeller Alexander 
Published: June 2020

AbstractBackgroundSmoking is a major preventable cause of morbidity and mortality. We assessed smoking behaviour in 6-17-year-olds. In 13-17-year-olds, we studied risk factors for smoking and compared the frequency of respiratory problems between those who smoked and those who did not.MethodsWe used data from LuftiBus in the school, a school-based survey of the respiratory health of children carried out 2013-2016 in the canton of Zurich, Switzerland. Participants were asked about cigarette, shisha, and electronic smoking device (ESD) smoking, and respiratory symptoms and diseases. We studied the association between smoking and risk factors using logistic regression.ResultsWe included 3488 schoolchildren with data on active smoking. Five percent of the 6-12-year-olds (90 of 1905) had smoked occasionally (<once/week). Among 13-17-year-olds (N=1583), 563 (36%) had smoked occasionally of whom 414 smoked ESDs, 409 shishas, and 276 cigarettes. Among 54 (3%) 13-17-year-olds who smoked frequently (≥once/week), 41 (76%) smoked cigarettes, and 22% of 15-17-year-olds (104/477) had smoked all three products. Smoking was more common in adolescents who were male, lived in rural areas, and whose mother (adjusted OR 1.7, 95% CI 1.3 - 2.3) or father (aOR 1.5, 95% CI 1.2 – 1.9) smoked. Respiratory symptoms in the past year such as rhinitis, dyspnoea, and wheeze were more common in adolescents who smoked frequently or occasionally than in never smokers.ConclusionSmoking of shishas and ESDs is popular among Swiss adolescents and often combined with smoking cigarettes. Structural smoking prevention strategies should include all forms of smoking including shishas and ESDs.
Modelling oral adrenal cortisol support
Authors: Smith David J. , Prete Alessandro , Taylor Angela E. , Karavitaki Niki , Arlt Wiebke 
Published: June 2020

AbstractA simplified mathematical model of oral hydrocortisone delivery in adrenal insufficiency is described; the model is based on three components (gastric hydrocortisone, free serum cortisol and bound serum cortisol) and is formulated in terms of linear kinetics, taking into account the dynamics of glucocorticoid–protein binding. Motivated by the need to optimise cortisol replacement in the situations of COVID-19 infection, the model is fitted to recently-published data on 50 mg dosing and earlier data on 10 mg dosing. The fitted model is used to predict typical responses to standard dosing regimes, which involve a larger dose in the morning and 1 or 2 smaller doses later in the day, and the same regimes with doses doubled. In all cases there is a circadian-like response, with early morning nadir. The model is also used to consider an alternative dosing strategy based on four equal and equally-spaced doses of 10, 20 or 30 mg per 24 h, resulting in a more even response resembling a response to sustained inflammatory stress.
SIR-PID: A Proportional-Integral-Derivative Controller for COVID-19 Outbreak Containment
Authors: Ianni Aldo , Rossi Nicola 
Published: June 2020

AbstractOngoing social restrictions, as distancing and lockdown, adopted by many countries for contrasting the COVID-19 epidemic spread, try to find a trade-off between induced economic crisis, healthcare system collapse and costs in terms of human lives. Applying and removing restrictions on a system with uncontrollable inertia, as represented by an epidemic outbreak, may create critical instabilities, overshoots and strong oscillations of infected people around the desirable set-point, defined as the maximum number of hospitalizations acceptable by a given healthcare system. A good understanding of the system reaction to a change of the input control variable can be reasonably achieved using a proportional-integral-derivative controller, widely used in technological applications. In this paper we make use of this basic control theory for understanding the reaction of COVID-19 propagation to social restrictions and for exploiting a very known technology to reduce the epidemic damages through the correct tuning of the containment policy.
Application of a novel analytical pipeline for high-dimensional multivariate mediation analysis of environmental data
Authors: Aung Max T. , Song Yanyi , Ferguson Kelly K. , Cantonwine David E. , Zeng Lixia , McElrath Thomas F. , Pennathur Subramaniam , Meeker John D. , Mukherjee Bhramar 
Published: June 2020

ABSTRACTDiverse toxicological mechanisms may mediate the impact of environmental toxicants (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. In this study we introduce an analytical pipeline for high-dimensional mediation analysis to identify mediation pathways (q = 63 mediators) in the relationship between environmental toxicants (p = 38 analytes) and gestational age at delivery. Our analytical pipeline included: (1) conducting pairwise mediation for unique exposure-mediator combinations, (2) subjecting mediators to Bayesian shrinkage mediation analysis and population value decomposition, and (3) exposure dimension reduction by estimating environmental risk scores. Dimension reduction demonstrated that a one unit increase in phthalate risk score was associated with a total effect of 1.09 lower gestational age (in weeks) at delivery (95% confidence interval: 1.78 – 0.36) and eicosanoids from the cytochrome p450 pathway mediated 24.5% of this effect (95% confidence interval: 4%-66%). Eicosanoid products derived from the cytochrome p450 pathway may be important mediators of phthalate toxicity.