bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population pharmacokinetics and dosing of dispersible moxifloxacin formulation in children with rifampicin‐resistant tuberculosis
Authors: Palmer Megan , Zou Yuanxi , Hesseling Anneke C. , van der Laan Louvina , Courtney Ingrid , Kinikar Aarti A. , Sonkawade Naresh , Paradkar Mandar , Kulkarni Vandana , Casalme Dessa Jean O. , Frias Melchor V. G. , Draper Heather , Wiesner Lubbe , Karlsson Mats O. , Denti Paolo , Svensson Elin M. , Garcia‐Prats Anthony J. 
Published: February 2025

AimsMoxifloxacin is a priority drug for treating rifampicin‐resistant tuberculosis (RR‐TB). We assessed the pharmacokinetics of a child‐friendly, dispersible 100 mg tablet moxifloxacin formulation (dispersed in water) compared to the standard 400 mg non‐dispersible formulation (crushed and suspended in water) in children and evaluated current dosing recommendations.MethodsThe CATALYST trial investigated the pharmacokinetics of moxifloxacin in children with RR‐TB. Children were enrolled in South Africa, India and the Philippines. Intensive pharmacokinetic sampling was undertaken while children were taking the standard non‐dispersible 400 mg moxifloxacin tablet formulation and repeated after switching to the novel dispersible formulation. Pharmacokinetic data were analysed using population pharmacokinetic modelling. Simulations were performed to evaluate moxifloxacin exposures in children compared to consensus adult reference exposures using current World Health Organization (WHO)‐recommended doses and more recent model‐based doses.ResultsThirty‐six children were enrolled [median age 4.8 (range 0.4–15) years and weight 15.6 (range 6.9–42.1) kg]. A two‐compartment disposition model with first‐order elimination and delayed absorption was developed. The bioavailability of dispersible versus standard formulations fulfilled standard bioequivalence criterion (ratio 1.05 with 90% confidence interval 0.95–1.15). Simulations showed WHO‐recommended doses achieved exposures similar to those in adults in children >10 kg, while children <10 kg may require 33%–56% higher doses to reach adult reference exposures.ConclusionsDosing recommendations for children can be the same for the dispersible paediatric and standard non‐dispersible adult moxifloxacin formulation. The current WHO dosing recommendation risks underdosing moxifloxacin in children <10 kg. We propose optimized moxifloxacin doses for both formulations.
Investigation of Listening Effort in Tinnitus Patients by Providing Similar Peripheral Auditory Function With Control Group
Authors: Sendesen Eser , Turkyilmaz Meral Didem 
Published: February 2025

ABSTRACTIntroductionPrevious studies have investigated listening effort in tinnitus patients compared to healthy individuals. These studies reported similar pure tone hearing thresholds between groups but did not investigate possible peripheral auditory dysfunction, which could affect the central auditory system and increase listening effort even when hearing thresholds are within the normal hearing range. This study aimed to investigate the presence of listening effort in tinnitus patients by controlling for peripheral auditory function (PAF).MethodsThis study included 16 chronic tinnitus patients and 23 matched healthy controls, both with normal hearing thresholds. The subjects were assessed using 0.125–20 kHz pure‐tone audiometry, a visual analogue scale (VAS), the Montreal Cognitive Assessment (MoCA), the Tinnitus Handicap Inventory (THI), the matrix test, auditory brainstem response (ABR), and electroencephalography (EEG). EEG alpha band activity was recorded from parietal electrodes (P3, P4, Pz).ResultsThe increase in alpha band power during the encoding phase of sentence presentation in tinnitus patients was less than that in the control group. We found higher VAS scores in tinnitus participants. We did not find significant differences in matrix test scores, ABR amplitude, or absolute latency values between groups. The EEG alpha power change and THI did not show a significant correlation.ConclusionTo the best of our knowledge, this is the first study to investigate the listening effort of tinnitus patients and healthy controls using EEG alpha band power while controlling for hearing and PAF. Tinnitus patients may expend more listening‐related effort despite having similar PAF to the control group.
How Are TBI Symptoms Interconnected? A Network Analysis Approach
Authors: Bindels Helen , Sommer Sascha , Ohmann Tobias , Seddigh Susann , Schuler Michael 
Published: February 2025

ABSTRACTBackgroundMany patients with traumatic brain injury (TBI) across all levels of severity experience persistent psycho‐emotional, cognitive, and somatic symptoms. Psychological network theory views disorders as intricate systems rather than discrete diseases. This study employs an exploratory network analysis method to uncover potential causal links among long‐term TBI symptoms.MethodsWe examined persistent symptoms using secondary data from 250 TBI patients undergoing an inpatient “brain check” procedure. We constructed two partial correlation networks: one for the entire sample and another for a mild TBI subgroup, each consisting of 14 symptoms and three covariates. The symptoms and their connections were visualized in network graphs to identify potential causal, and structural indicators and centrality indices were calculated.ResultsThe analysis revealed two dense networks characterized by multiple complex connections. In the overall network, symptoms are clustered into psycho‐emotional and cognitive communities, with attention deficits serving as a crucial link between them. One finding was that self‐reported cognitive impairments do not align with objectively measured deficits. Within the mild TBI subgroup, PTSD emerges as a central node in the network.ConclusionNetwork analysis reveals the multidimensional and reciprocal nature of long‐term TBI symptoms. Attention deficits bridge cognitive and psycho‐emotional areas, whereas psycho‐emotional symptoms influence self‐perceived performance. Self‐reported cognitive impairments should be emphasized in therapy as they are linked rather to sleep, visual disturbances, and anxiety than to objective deficits. Network analysis is valuable for understanding TBI symptom complexity and exploring treatment options. Future research should utilize longitudinal designs to validate our findings.
The Synthesis Effects on the Performance of P2‐Na0.6Li0.27Mn0.73O2 Cathode Material for Sodium‐Ion Batteries
Authors: Zeng Cuihong , Zhang Ziqin , Peng Jiming , Qiao Jia , Pan Qichang , Zheng Fenghua , Huang Youguo , Wang Hongqiang , Li Qingyu , Hu Sijiang 
Published: February 2025

ABSTRACTSodium‐layered oxides are a promising category of cathodes for sodium‐ion batteries with high energy densities. The solid‐state method is the typical approach to synthesizing these oxides because of its simple procedure and low cost. Although the reaction conditions have usually been understated, the effect of reagents has often been overlooked. Thus, fundamental insight into the chemical reagents is required to perform well. Here we report in situ structural and electrochemical methods of studying the effect of using different reagents. The materials have a composite structure containing layered NaMnO2 and Li2MnO3 components, where oxygen anionic redox can be triggered at high voltage by forming Na–O–Li configurations. The samples synthesized via MnCO3‐based precursors form the Li2MnO3 phase at evaluated temperature and perform better than those through MnO2‐based precursors. This work demonstrates that the reagents also impact the structure and performance of sodium‐layered oxides, which provides new insight into developing high‐energy cathode material.
Thriving: The Positive Experiences of Tenured Faculty Mothers in Counselor Education
Authors: Appling Brandee M. , Crumb Loni , Stubbs‐Brown Breanna V. , Crawford Carey C. 
Published: February 2025

ABSTRACTIn this feminist phenomenological study, experiences of tenured faculty mothers in counselor education were explored. The researchers developed five themes: (a) linking motherhood to counselor education, (b) creating work–life harmony, (c) establishing multiple layers of support, (d) celebrating the wins, and (e) pushing back and moving forward. These findings suggest that mothers in counselor education have a range of experiences that shape their personal and professional identities and buttress career success. Research, practice, and advocacy implications are addressed.
Implementation of beaker CP for flow cytometry: Workflow optimization and integration at Stanford Health Care
Authors: Oak Jean , Gitana Gary , Wei Sibing , Parry Melissa , Tan Brent 
Published: February 2025

AbstractImplementing a new laboratory information system (LIS) presents an opportunity to improve operational efficiency and streamline reporting by refining workflows by utilizing LIS functionality. Flow cytometry laboratories face unique challenges because the specimen and test results may be categorized under clinical pathology (CP), anatomic pathology (AP), or both. We describe the design and implementation of reporting flow cytometry results within the Epic Beaker CP module, its interface with the Epic Beaker AP module, and integrated reporting for AP/CP cases at an academic institution. This manuscript emphasizes the challenges and steps needed to integrate anatomic and clinical pathology workflows by leveraging LIS functionality to implement electronic and predominantly paperless workflows within a flow cytometry laboratory.
Adults With Dyslexia Use Internalised Beat Cues Less Than Controls When Estimating Interval Length
Authors: Torres Nathércia Lima , Batista Ana Rita , Sousa José , Folia Vasiliki , Baltos Dimitris , Mesquita Ana , Silva Susana 
Published: February 2025

ABSTRACTDifficulties in both duration and beat‐based time perception are common in individuals with dyslexia (DD). It is also known that internalised beat cues may aid in duration processing. This study investigated whether the difficulties in duration processing among DD stem from their inability to utilise internal beat cues. Participants with and without dyslexia estimated intervals ranging from 500 ms to 10 s. In the beat cue condition, participants listened to a sequence of 500 ms beats before the interval, and in the no beat cue condition, they were exposed to silence while EEG was recorded. Interestingly, the two groups did not differ in duration estimation performance, but they did differ in their utilisation of beat cues, with DD showing less sensitivity to these, whether the impact was negative (cues before shorter intervals) or positive (before longer intervals). Brainwave entrainment to the target frequency was significantly higher compared with entrainment to a non‐target frequency, and cross‐group differences were null. Our findings suggest that DD may have difficulties either in retaining the beat when it is no longer audible, or in using the internalised beat for duration estimation. Nevertheless, they can achieve comparable accuracy to neurotypical adults, possibly through compensatory strategies.
Chirality Communication and Transmission within Palladium(II) Quadruple‐stranded Helicates
Authors: Ma Zhao , Gan Quan 
Published: February 2025

Over the past few decades, supramolecular chirality in discrete metallosupramolecular architectures has garnered significant attention. This concept offers a comprehensive overview of chiral metal‐organic coordination‐driven structures, particularly those of the M₂L₄ type. The focus is on recent advancements in quadruple‐stranded metallosupramolecular complexes, where chirality emerges not from a specific arrangement of ligands around metal centers, but rather from ligand twisting and inter‐ligand interactions. Special emphasis is placed on homochiral metallo‐assemblies, exploring chiral intra‐ and inter‐molecular transmission and chirality induction via guest encapsulation. We hope this concept will be of interest to researchers aiming to design novel, intricate homochiral metallosupramolecular structures with increased complexity and enhanced functional potential.
The Effect of Proximity‐To‐Failure on Perceptual Responses to Resistance Training
Authors: Refalo Martin C. , Helms Eric R. , Hamilton D. Lee , Fyfe Jackson J. 
Published: February 2025

ABSTRACTPerceptual responses may influence how much pleasure or displeasure an individual experiences during or following resistance training (RT). Resistance‐trained males (n = 12) and females (n = 6) completed an 8‐week intervention involving two RT sessions per week. The lower limbs of each participant were randomised to perform the leg press and leg extension exercises either to (i) momentary muscular failure (FAIL) or (ii) a perceived 2‐RIR and 1‐RIR, respectively, for the entire intervention. In weeks one, four, and eight, post‐set ratings of perceived discomfort (RPD), and post‐session ratings of perceived exertion (RPE) and general feelings via feeling scale (FS) were measured. Data were analysed with Bayesian mixed‐effect models. When averaged over all time points measured, results showed slightly greater RPD for FAIL [5.1 (HDI: 4.2–6.0); pd = 100%] versus RIR [4.1 (HDI: 3.2–5.1); pd = 100%], greater RPE for FAIL [5.4 (HDI: 4.6–6.3); pd = 100%] versus RIR [4.3 (HDI: 3.5–5.1); pd = 100%], and more positive general feelings for RIR [1.2 (HDI: 0.7–1.8); pd = 100%] versus FAIL [0.3 (HDI: −0.3 to 0.8); pd = 86%]. Overall, assessing perceptual responses may help inform RIR prescription to promote desired outcomes whilst limiting negative feelings that may compromise long‐term adherence.
Early PCOS Detection: A Comparative Analysis of Traditional and Ensemble Machine Learning Models With Advanced Feature Selection
Authors: Mohi Uddin Khandaker Mohammad , Bhuiyan Md. Tofael Ahmed , Rahman Md. Mahbubur , Islam Md. Manowarul , Uddin Md Ashraf 
Published: February 2025

ABSTRACTPCOS (polycystic ovary syndrome) is a common hormonal disorder that affects many women during their reproductive years. It is marked by hormonal imbalances, leading to ovarian cysts, and can result in health issues such as infertility, diabetes, and even heart problems. Diagnosing PCOS accurately and early can be challenging, as it requires specific medical expertise. However, spotting PCOS promptly allows individuals to follow medical recommendations, which can lead to healthier lifestyles. In this study, we examined a dataset consisting of 541 patient records to enhance the detection of PCOS using advanced machine learning techniques. We established a data preprocessing pipeline that rigorously addressed missing values and identified outliers, while also normalizing the data to ensure it was ready for input. For feature selection, we applied advanced techniques such as SelectKBest, Chi‐Square, and XGBoost. These methods helped us pinpoint the most predictive attributes, which improved the interpretability and efficiency of our models. Hyperparameter tuning was carefully performed through grid search and cross‐validation, ensuring that each model was optimized for the best prediction accuracy. Importantly, our research highlights how effective machine learning can be in predicting PCOS. The logistic regression and support vector machine model stood out with its remarkable accuracy of 99.7753%. Furthermore, we created a user‐friendly web application to facilitate smooth deployment and real‐time analysis. This provides healthcare professionals with a handy tool for identifying early risks related to PCOS. The web application features an intuitive interface where users can easily input clinical information and receive immediate risk assessments.
A 3D SEM‐FEM Multiscale Framework for Seismic Analysis of Hydraulic Tunnels Considering Source‐to‐Structure Simulation
Authors: Sun Benbo , Deng Mingjiang , Xu Yan , Xu Jia 
Published: February 2025

ABSTRACTThe realistic prediction or simulation of the seismic behaviour of critical structures is highly sensitive to many aspects, including the earthquake source, propagation path, region topography, geological conditions and local complex structural dynamic analysis system. However, integrating the above key factors in a framework for generating realistic ground motions (GMs) and conducting dynamic analyses at specific engineering sites remains challenging. This task necessitates assessing the crucial elements involved in the seismic design of hydraulic tunnels (HTs), with the ultimate objective of safeguarding human lives in areas prone to seismic activity. To achieve this objective, a multiscale framework leveraging the spectral element method (SEM) and finite element method (FEM) is proposed. This framework involves establishing a coupling strategy between the SEM and FEM to address geological media–structure interaction problems. The SEM is utilised to generate and propagate elastic waves within the soil, while the FEM allows the studied structure to be comprehensively represented. The coupling technique is implemented using the weak‐coupling strategy in conjunction with the time domain reduction method (DRM). Then, a series of dynamic analyses and seismic performance assessments of the HT with the coupling SEM‐FEM method are conducted. The results indicate that (1) the nonlinear dynamic responses of the HT induced by the physical‐based GM align with the recorded GMs, verifying the practicability of the proposed framework for source‐to‐HT simulation; (2) physical‐based GMs of the hanging wall and foot wall, rupture fault distances and mountain locations can significantly impact the seismic performance of HTs.
Model Parameter Estimation for Hysteretic Behavior Simulation of FRP‐Jacketed Reinforced Concrete Columns
Authors: Kim Yoon Jae , Lee Chang Seok , Jeon Jong‐Su 
Published: February 2025

ABSTRACTFiber‐reinforced polymer (FRP) composite jackets have been widely used to retrofit reinforced concrete (RC) columns within structural systems. This study proposes a lumped plasticity model to simulate the nonlinear load‐deformation response of FRP‐jacketed RC columns under seismic loading. An experimental database of 98 FRP‐jacketed RC columns was assembled, including those with partial‐ or full‐height jackets, circular or rectangular cross‐sections, continuous or lap‐spliced longitudinal reinforcement, and various FRP materials. The database is used to calibrate parameters of the hysteretic material model. Regression analysis was conducted to develop model predictive equations. Each predictive equation was established using leave‐one‐out cross‐validation from 10 candidate design variables. Among the candidate FRP‐related design variables, the FRP quantitative ratio and its ultimate strength were selected for inclusion in the empirical model parameter equations. The proposed model demonstrates better accuracy than the existing model in reproducing experimental load‐deformation responses. Finally, the proposed model was applied to an FRP‐retrofitted RC building frame with lap‐spliced rebars to examine the seismic performance of the FRP retrofit compared with existing approaches. Overall, the proposed lumped plasticity approach for FRP‐jacketed RC columns offers improved versatility, accommodating a broad spectrum of column geometries, and computational efficiency with reasonable accuracy in predicting load‐deformation response.
Västlänken E02‐Centralen – Large excavation pit in Gothenburg's soft clay retained by diaphragm walls
Authors: Sawitzki Holger , Bürger Olaf , Scholz Christian 
Published: February 2025

AbstractCurrently, comprehensive construction works are ongoing within the West Link Project in Gothenburg, whereby a railway tunnel is built below central Gothenburg, consisting of five construction lots including three underground stations. The purpose of the Centralen lot is to connect the commuter traffic to Nils Ericson terminal and to Gothenburg's Central Station by a new four‐track underground station with two platforms. Designed as an underground structure, the new station was built by NCC Infrastructure (NCC) as a cut‐and‐cover tunnel. As the ground consists only of very soft clay down to great depth, the design and construction of the underground station was particularly challenging. Additionally, the complexity of the site conditions is enhanced by limited space, adjacent buildings and existing infrastructure crossing the site. Swedish Transport Administration, Trafikverket (TrV) decided for an early contractor involvement (ECI) contract to overcome the challenges of the Centralen lot. In the first phase, a multidisciplinary project team defined the construction methods, logistical constraints, general design and set a target price. Wayss & Freytag Ingenieurbau AG (W&F) was appointed as a subcontractor for heavy special foundation works. The team developed a solution using diaphragm walls (D‐Walls) to create the excavation pit for the new station, which is up to 18 m deep and 50 m wide. S&C Consult GmbH (S&C) served as a consultant during the planning and construction phase and in the quality assurance of the D‐Walls. It should be emphasised that this was only the fifth D‐Wall project in Sweden. Thanks to the constructive and open cooperation of all parties, the work was successfully completed on schedule in July 2023.
Assessing UVA and Laser‐Induced Crosslinking via Brillouin Microscopy
Authors: Iriarte‐Valdez Christian A. , Wenzel Johannes , Baron Emilie , Claus Alexandra Y. , Kalies Stefan , Sperlich Karsten , Stachs Oliver , Torres‐Mapa Maria Leilani , Heisterkamp Alexander 
Published: February 2025

ABSTRACTKeratoconus and other corneal ectatic disorders involve the degradation of collagen fibers, which compromises the corneal biomechanical properties. Ultraviolet‐A (UVA) crosslinking has emerged as the primary treatment to slow down collagen degradation. This treatment is limited in both penetration depth and spatial precision, potentially leading to unwanted side effects. This study compares the changes in biomechanical properties of corneas crosslinked with UVA irradiation and a near‐infrared femtosecond laser, using Brillouin microscopy. The biomechanical properties of the crosslinked regions were mapped in terms of Brillouin frequency shift in three dimensions. UVA crosslinking showed an average increase in Brillouin frequency shift of ~100 MHz. We demonstrate targeted spatial and axial corneal femtosecond crosslinking, with similar Brillouin frequency shift values to UVA in crosslinked regions.
Photobiomodulation of Blue Light Enhance Melanoma Cellular Recovery Following Viral Infection via Mitochondrial Pathways
Authors: Qin Haokuan , Jiang Hui , Huang Shijie , Yang Jiali , Fu Qiqi , Zhang Ruixiao , Chen Zeqing , Liu Muqing 
Published: February 2025

ABSTRACTThis study aimed to elucidate the response of B16F10 cells to blue light following infection with an empty adenoviral vector (Adv). Twenty‐four hours post‐infection, the B16F10 cells underwent phototherapy, and a range of cellular parameters were assessed, including cell viability, melanin content, cell cycle progression, reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP), apoptosis, necrosis, lactate dehydrogenase (LDH) release, and autophagy. The findings indicated that Adv infection elevated melanin content and autophagy, resulting in G1 phase cell cycle arrest. In comparison to the control group, light‐treated, Adv‐infected cells exhibited reduced inhibition rates, LDH release, apoptosis, and necrosis, while MMP and ROS levels were elevated. The study concluded that although Adv, as a gene delivery vector in conjunction with light therapy, significantly modulated melanin content and autophagy. Moreover, while melanin's light absorption capacity mitigated MMP reduction, the resultant excitation molecules generated ROS, enhancing oxidative stress.