bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective study to explore the relationship between MTHFR C677T genotype, physiological folate levels, and postpartum psychopathology in at-risk women
Authors: Morris Emily , Hippman Catriona , Albert Arianne , Slomp Caitlin , Inglis Angela , Carrion Prescilla , Batallones Rolan , Andrighetti Heather , Ross Colin , Dyer Roger , Honer William , Austin Jehannine 
Published: December 2020

Background
The etiology of postpartum psychopathologies are not well understood, but folate metabolism pathways are of potential interest. Demands for folate increase dramatically during pregnancy, low folate level has been associated with psychiatric disorders, and supplementation may improve symptomatology. The MTHFR C677T variant influences folate metabolism and has been implicated in depression during pregnancy.

Objective
To conduct a prospective longitudinal study to explore the relationship between MTHFR C677T genotype, folate levels, and postpartum psychopathology in at-risk women.

Hypothesis
In the first three months postpartum, folate will moderate a relationship between MTHFR genotype and depression, with TT homozygous women having more symptoms than CC homozygous women.

Methods
We recruited 365 pregnant women with a history of mood or psychotic disorder, and at 3 postpartum timepoints, administered the Edinburgh Postnatal Depression Scale (EPDS); Clinician-Administered Rating Scale for Mania (CARS-M) and the Positive and Negative Symptom Scale (PANSS) and drew blood for genotype/folate level analysis. We used robust linear regression to investigate interactions between genotype and folate level on the highest EPDS and CARS-M scores, and logistic regression to explore interactions with PANSS psychosis scores above/below cut-off.

Results
There was no significant interaction effect between MTHFR genotype and folate level on highest EPDS (p = 0.36), but there was a significant interaction between genotype, folate level and log(CARS-M) (p = 0.02); post-hoc analyses revealed differences in the effect of folate level between CC/CT, and TT genotypes, with folate level in CC and CT having an inverse relationship with symptoms of mania, while there was no relationship in participants with TT genotype. There was no significant interaction between MTHFR genotype and folate level on the likelihood of meeting positive symptom criteria for psychosis on the PANSS (p = 0.86).

Discussion
These data suggest that perhaps there is a relationship between MTHFR C677T, folate level and some symptoms of postpartum psychopathology.
Epidemiology and the diagnostic challenge of extra-pulmonary tuberculosis in a teaching hospital in Ethiopia
Authors: Arega Balew , Mersha Amdemeskel , Minda Abraham , Getachew Yitagesu , Sitotaw Alazar , Gebeyehu Tefera , Agunie Asnake 
Published: December 2020

BackgroundEthiopia reported a high rate of extra-pulmonary tuberculosis (EPTB) and the cases are increasing since the last three decades. However, diagnostic evidence to initiate TB treatment among EPTB cases is not well known. Therefore, we described the epidemiology and assessed how EPTB is diagnosed in a teaching hospital in Ethiopia.MethodsWe conducted a retrospective review among all adult EPTB cases diagnosed in Yekatit 12 Hospital Medical College from 2015 to 2019. Using a standardized data abstraction sheet, we collected data from patients’ medical records on sociodemographic, sites, and laboratory diagnosis of EPTB cases.ResultsOf the 965 total TB cases, 49.8%(481) had a recorded diagnosis of EPTB during the study period. The mean age of EPTB patients was 32.9 years (SD±13.9) and 50.7% were males. Tubercular lymphadenitis (40.3%), abdominal (23.4%), and pleural TB(13.5%) were the most common sites of EPTB involvement, followed in descending order by the genitourinary, skeletal, central nervous system, abscess, breast, and laryngeal TB. We found a histopathology finding consistent with EPTB in 59.1% of cases, Acid-fast bacilli positive in 1.5%, and the rest diagnosed on radiological grounds. In the majority of cases, more than one diagnostic method was used to diagnose EPTB cases.ConclusionsNearly half of TB patients had a recorded diagnosis of EPTB that comprise heterogeneous anatomical sites. All EPTB patients were started anti-TB therapy without definitive microbiology results. This indicates the diagnostic challenge of EPTB faced in our setting and proves to be significant for TB control in Ethiopia.
Associations between legal performance-enhancing substance use and future cardiovascular disease risk factors in young adults: A prospective cohort study
Authors: Nagata Jason M. , Ganson Kyle T. , Cunningham Mitchell L. , Mitchison Deborah , Lavender Jason M. , Blashill Aaron J. , Gooding Holly C. , Murray Stuart B. 
Published: December 2020

Background
Legal performance-enhancing substances (PES), such as creatine, are commonly used by adolescents and young adults. As PES are mostly unregulated by the US Food and Drug Administration, there has been limited empirical attention devoted to examining their long-term safety and health outcomes. Preliminary studies have demonstrated associations between PES use and severe medical events, including hospitalizations and death. PES could be linked to cardiovascular disease (CVD), the most common cause of mortality in the US, by altering the myocardium, vasculature, or metabolism. The objective of this study was to examine prospective associations between the use of legal PES in young adulthood and CVD risk factors at seven-year follow-up.

Materials and methods
Nationally representative longitudinal cohort data from the National Longitudinal Study of Adolescent to Adult Health, Waves III (2001–2002) and IV (2008), were analyzed. Regression models determined the prospective association between the use of legal PES (e.g. creatine monohydrate) and CVD risk factors (e.g. body mass index, diabetes, hypertension, hyperlipidemia), adjusting for relevant covariates.

Results
Among the diverse sample of 11,996 male and female participants, no significant differences by PES use in body mass index, diabetes, hypertension, or hyperlipidemia were noted at Wave III. In unadjusted comparisons, legal PES users (versus non-users) were more likely to be White, be male, be college educated, drink alcohol, and engage in weightlifting, exercise, individual sports, team sports, and other strength training. There were no significant prospective associations between legal PES use at Wave III and body mass index, hemoglobin A1c, systolic and diastolic blood pressure, and cholesterol (total, HDL, LDL, triglycerides) deciles at seven-year follow-up (Wave IV), adjusting for demographics, health behaviors, and Wave III CVD risk factors. Similarly, there were no significant prospective associations between legal PES use and diabetes, hypertension, or hyperlipidemia based on objective measures or self-reported medications and diagnoses, adjusting for demographics, health behaviors, and Wave III CVD risk.

Conclusions
We do not find evidence for a prospective association between legal PES use and CVD risk factors in young adults over seven years of follow-up, including BMI, diabetes, hypertension, or hyperlipidemia. It should be noted that legal PES use was operationalized dichotomously and as one broad category, which did not account for frequency, amount, or duration of use. Given the lack of regulation and clinical trials data, observational studies can provide much needed data to inform the safety and long-term health associations of legal PES use and, in turn, inform clinical guidance and policy.
Factors affecting mental health of health care workers during coronavirus disease outbreaks (SARS, MERS & COVID-19): A rapid systematic review
Authors: De Brier Niels , Stroobants Stijn , Vandekerckhove Philippe , De Buck Emmy 
Published: December 2020

Introduction
The novel Coronavirus Disease (COVID-19) outbreak currently puts health care workers at high risk of both physical and mental health problems. This study aimed to identify the risk and protective factors for mental health outcomes in health care workers during coronavirus epidemics.

Methods
A rapid systematic review was performed in three databases (March 24, 2020) and a current COVID-19 resource (May 28, 2020). Following study selection, study characteristics and effect measures were tabulated, and data were synthesized by using vote counting. Meta-analysis was not possible because of high variation in risk factors, outcomes and effect measures. Risk of bias of each study was assessed and the certainty of evidence was appraised according to the GRADE methodology.

Results
Out of 2605 references, 33 observational studies were selected and the identified risk and protective factors were categorized in ten thematic categories. Most of these studies (n = 23) were performed during the SARS outbreak, seven during the current COVID-19 pandemic and three during the MERS outbreak. The level of disease exposure and health fear were significantly associated with worse mental health outcomes. There was evidence that clear communication and support from the organization, social support and personal sense of control are protective factors. The evidence was of very low certainty, because of risk of bias and imprecision.

Conclusion
Safeguarding mental health of health care workers during infectious disease outbreaks should not be treated as a separate mental health intervention strategy, but could benefit from a protective approach. This study suggests that embedding mental health support in a safe and efficient working environment which promotes collegial social support and personal sense of control could help to maximize resilience of health care workers. Low quality cross-sectional studies currently provide the best possible evidence, and further research is warranted to confirm causality.
Nurses' compliance to patient and environmental safety guidelines in critical care units
Authors: Aly Abd Elhamid Eman , Ezz Eldin Abdallah Nehad , Mohamed Abd Elrahman Safaa 
Published: December 2020

The ability to provide safe and high-quality care to patients is the primary goal and the focus for many health care providers. Guidelines can be used to reduce adverse event in practice and to promote the delivery of high quality and evidence-based health care. The aim of the study to investigate nurses' compliance to patient and environmental safety guidelines in critical care units. Descriptive research design was utilized to achieve the aim of this study. The study was carried out at three of Minia University Hospitals in Minia city. All available nurses (n= 88) who were working in critical care units at time of data collection in the selected hospitals. An environmental and patient safety guidelines questionnaire was used to achieve the aim of this study. Results: less than two third of studied subject were not compliance to patient safety nurses', while nurses complied to environmental safety with 62.5% in critical care units; also, there is highly statistical significance between departments and nurses' compliance to patient safety. Thus, it was concluded that less than two third of studied subject were not compliance to patient safety. As well as environmental safety in critical care units was appropriate with 62.5% in critical care units. Recommendations: Staff development programs for nurses working in critical care units related to patient and environmental safety as well as ensuring that the organizationâ€™s annual budget includes adequate resources to implement and evaluate health and safety activities.Â Â
Relationship of fear and fatalism with breast cancer screening among women using health belief model
Authors: Amin Hassan Fahmy Elsaba Howaida , Samir Ahmed Abd El-Maksoud Amal 
Published: December 2020

Despite the potential benefits of screening in discovering breast cancer, many women still do not follow recommended screening regimens. Fear of cancer detection and fatalistic beliefs were identified by previous studies as the main reasons given by women for noncompliance with breast cancer screening. The aim of this descriptive study is to explore relationship of fear and fatalism with breast cancer screening among a convenience sample of 136 women recruited during their visit to the Gynecology Clinic at the Maternity University Hospital in Alexandria, Egypt. The study tool consists of four parts: (1) Bio-sociodemographic information; (2) Champion Breast Cancer Fear Scale (CBCFS); (3) Powe Fatalism Inventory (PFI); (4) abridged version of the Champion Health Belief Model Scale (CHBMS). The findings revealed that only 3.7% and 14.7% of women practiced regular breast self-examination and had previously had mammography, respectively. Negative correlations were found between fatalism and health beliefs; and between fear and health belief. A positive correlation was found between fatalism and fear. The findings of this study add some experimental support for the relationships between fear, fatalism, and breast cancer screening behavior.Â Â
Seismic Inversion for the Calculation of Velocities Using the Generalized Inverse Linear Matrix, the Wave Equation, and a Non-Reflective-Boundaries Condition
Authors: Duitama Leal Alejandro , González Veloza José John Fredy , Castillo López Luis Antonio , Gil Gómez Javier Hernán , Esquivel Rodrigo Elías 
Published: December 2020

Objective: this work presents the results obtained in the development of a seismic velocity inversion mo­del. The reference times recorded on the surface are taken and using the inversion model to obtain the initial reference model (hypocenters and velocities), starting from an unknown model.
Methodology: A hypothetical reference model is pro­posed containing 64 blocks with interval velocity, 16 recording stations on the surface, and 64 earth­quakes in the center of each block. With this model, the reference arrival times are generated for each ear­thquake registered in each station. The inversion mo­del is made up of two parts: the direct model, which allows calculating the arrival times of the signal regis­tered on the surface according to the hypo-central lo­cation of the earthquake and the velocity of the P and S wave of the medium; and the inverse model, which estimates a model of the velocity of the environment and hypo-central locations of the earthquakes that are the input variables of the direct model. The direct model was developed with the wave equation, while the inverse model was developed by modifying the generalized inverse matrix by introducing a factor called “damping.”
Results: The discretization model is based on the finite difference method.. When estimating the values of velocity and hypo-central location with the inverse algorithm, the propagation of the wave is simulated with the direct model, and they are compared with the data of reference times measured on the surface. Depending on the value of the mean square error, we proceed to modify the mean velocities and hypo­centers of the earthquakes. This process is repeated iteratively until the calculated error is less than a to­lerance of 2x10-3s2.
Conclusions: It was found that the estimated values of velocity and hypo central locations coincide well for regions closer to the surface, while for deep regions the error is greater compared to the hypothetical re­ference model.
Matching Accounting Curricula with Market Demands: A Study on the University of Rajshahi in Bangladesh
Authors: Hossain S. Z. , Haque M. A. , Rahman M. T. 
Published: December 2020

The study strived to explore whether the accounting curricula of the University of Rajshahi fit the needs of both domestic and foreign job markets. To accomplish this purpose, we prepared five sets of Likert-type structured questionnaires and administered them to stakeholders viz faculties, students, alumni, non-academic staff, and employers. The Higher Education Quality Enhancement Program (HEQEP) of the University Grants Commission of Bangladesh provided the questionnaires. The study found a notable gap between the courses and content covered in the accounting curricula and the skills acquired by the graduates as well their skills and needs of the job market. The Department of Accounting and Information Systems of the University developed the accounting curricula without any participation of its stakeholders and professional body members. Faculties designed curricula, but it was just routine work. Recently it has mandatory to include a member from alumni, employers, and professionals in the curriculum committee. But they have very little freedom to exercise their rights and give inputs to a curriculum to meet the needs of the job market. Moreover, the prevailing lecture-based teaching-learning pedagogy and exam-based assessment practiced by universities expand the gap. The study recommends proper representation of stakeholders in the curricula Committee and designing market-led forward-looking curricula for accounting programs giving emphasis on information technology and taking into account the demands of the prevailing and prospective job markets.
Regulation of “Classic” Community-Based Charitable Organizations
Authors: Barber Putnam , Smith Steven Rathgeb 
Published: December 2020

Abstract
Tax-exempt organizations in the United States are, in general, required to file regular reports on their operations with the Internal Revenue Service (IRS). These filings represent a significant burden for the filing organizations, are a critical source of information for many observers, and are relied upon by regulators and donors as indicators of the organizations’ commitment to achieving the wide variety of purposes for which the exemptions are granted. This paper recommends that the resources of the IRS be refocused so that greater attention can be paid to complex organizations, while the burden of preparing annual filings by simpler organization is also reduced. More generally, this paper also recommends that new attention be paid to the information collected and to its publication. It argues that the needs of the public and other regulatory agencies are not well-served by the current information and that the limitations on currently available information contribute to misunderstanding of and cynicism about the role of charitable nonprofits in American life.
Analysis of Long-Term Performance and Snowmelt Capacity of Anti-Freezing Asphalt Pavement
Authors: Wu Shujuan , Zheng Mulian , Liu Qing , Zhou Wen , Li Yifeng , Ma Zonghui 
Published: December 2020

Abstract
Anti-Freezing Asphalt Pavement (AFAP) has good snow-melting performance and is used widely in many countries around the world. The objective of this study was to analyze AFAP’s long-term performance and predict its snow-melting ability. Two types of anti-freezing stone matrix asphalt (SMA) mixtures (SMA-13 with Iceguard and SMA-13 with Mafilon) were prepared with the Marshall method. Water stability, high-temperature stability, low-temperature crack resistance, and freeze-thaw split tests were conducted to evaluate mixtures’ performance. Meanwhile, the effect of anti-freezing filler, asphalt content, and soaking temperature on the salt dissolution of anti-freezing asphalt mixtures was analyzed, and the snow-melting ability of AFAP was predicted based on the Back Propagation (BP) neural network. The results illustrated that water stability of anti-icing asphalt mixture reduced, and the dynamic stability after short-term aging was improved. The tensile strain and tensile strength ratio of the anti-icing asphalt mixture reduced after long-term aging and soaking in water. In addition, the salt dissolution rate increased with the increase of anti-freezing filler content and the decrease of asphalt content. The research conducted suggests that the BP Neural Network can be utilized to predict the snow-melting ability of the anti-freezing asphalt mixture, and the regression coefficient of the predicted and measured salt dissolution was higher.
Total Volume Change Measurement of Unsaturated Soil in Triaxial Tests: A New Approach
Authors: de Campos Tácio M. P. , de O. Carvalho Taíse M. , Viana Ana Carolina de C. 
Published: December 2020

Abstract
In the evaluation of unsaturated soil behavior in the laboratory, it is required to measure the total volume change of triaxial soil specimens. This, however, is not an easy task, with setups proposed in the literature being quite expensive or presenting variable setbacks. In this context, this article presents a new, reliable, cheap system to estimate the total volume change of the soil in unsaturated conditions in triaxial tests. To do so, a double-chamber triaxial cell was developed, with the inner cell connected to an air-tight container subjected to the same cell pressure and positioned on a precision analytical scale. The measure of the total volume change is given by the mass of water entering or leaving the air-tight container. After calibration, the system was tested under consolidation using saturated soil samples. Comparing the conventional change in water volume of the saturated specimen with the variation of the total volume obtained through the developed system, a maximum difference of 0.01 cm3 is obtained, which equals only 0.01 % of the specimen volume. The effects of temperature and of cell pressure variation, which might occur during the saturation of unsaturated specimens in conventional triaxial tests, are also presented and discussed.
An Experimental Study on Physical, Mechanical, and CO2 Permeability Behavior of Sandstone after High-Temperature Treatment
Authors: Yang Sheng-Qi , Dong Zhi-Jin , Huang Yan-Hua , Teng Shang-Yong 
Published: December 2020

Abstract
In order to investigate the influence of temperature and complex stress state on the physical, mechanical, and CO2 permeability behavior of sandstone, the Brazilian splitting test, uniaxial compression test, and permeability test were carried out under different cooling modes after high-temperature heat treatment (100°C, 200°C, 300°C, 400°C, 500°C, 600°C, 700°C, 800°C, and 900°C). The changes of the physical parameters of the specimens before and after high-temperature treatment were compared. The variation law of mechanical behavior under different temperatures and cooling modes was investigated. The variation law of CO2 permeability in two cooling modes under different confining pressure and osmotic pressure was analyzed. The experimental results show that the sandstone specimen increases in volume while the mass and density decrease with the increase of temperature. The specimens show brittle failure after peak stress in the range of all the tested temperature, and with the increase of temperature, the tensile strength, compressive strength, and elastic modulus decrease in the range of 200°C and below, then increase from 200°C to 400°C, and finally decrease after 400°C. At a certain temperature, the permeability decreases as the confining pressure increases. In two different cooling modes, it was found that after rapid cooling, the specimens had higher CO2 permeability than those that underwent normal cooling. Moreover, these findings are further discussed in the scanning electron microscopy analysis. The physical, mechanical, and CO2 permeability behavior are closely related to the development of internal cracks in sandstone as the temperature increases.