bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Precise and Cost-Effective Technique to Measure Deliquescent Relative Humidity of Particulate Contaminants and Determination of the Operating Relative Humidity of a Data Center Utilizing Airside Economization
Authors: Shah Jimil M. , Anand Roshan , Singh Prabjit , Saini Satyam , Cyriac Rawhan , Agonafer Dereje , Kaler Mike 
Published: June 2020

Abstract
A remarkable amount of energy in data centers is consumed in eliminating the heat generated by the information technology (IT) equipment to maintain and ensure safe operating conditions and optimum performance. The installation of airside economizers (ASEs), while very energy efficient, bears the risk of particulate contamination in data centers, hence, deteriorating the reliability of IT equipment. When relative humidity (RH) in data centers exceeds the deliquescent relative humidity (DRH) of salts or accumulated particulate matter, it absorbs moisture, becomes wet, and subsequently leads to electrical short-circuiting because of degraded surface insulation resistance (SIR) between the closely spaced features on printed circuit boards (PCBs). Another concern with this type of failure is the absence of evidence that hinders the process of evaluation and rectification. Therefore, it is imperative to develop a practical test method to determine the DRH value of the accumulated particulate matter found on PCBs. This research is a first attempt to develop an experimental technique to measure the DRH of dust particles by logging the leakage current versus RH% for the particulate matter dispensed on an interdigitated comb coupon. To validate this methodology, the DRH of pure salts like MgCl2, NH4NO3, and NaCl is determined, and their results are then compared with their published values. This methodology was therefore implemented to help lay a modus operandi of establishing the limiting value or an effective relative humidity envelope to be maintained at a real-world data center facility situated in Dallas industrial area for its continuous and reliable operation.
Community health workers for pandemic response: a rapid evidence synthesis
Authors: Bhaumik Soumyadeep , Moola Sandeep , Tyagi Jyoti , Nambiar Devaki , Kakoti Misimi 
Published: June 2020

IntroductionCoronavirus disease (COVID-19), affects 213 countries or territories globally. We received a request from National Health Systems Resource Centre, a public agency in India, to conduct rapid evidence synthesis (RES) on community health workers (CHWs) for COVID-19 prevention and control in 3 days.MethodsWe searched PubMed, websites of ministries (n=3), public agencies (n=6), multilateral institutions (n=3), COVID-19 resource aggregators (n=5) and preprints (n=1) (without language restrictions) for articles on CHWs in pandemics. Two reviewers screened the records independently with a third reviewer resolving disagreements. One reviewer extracted data with another reviewer cross-checking it. A framework on CHW performance in primary healthcare not specific to pandemic was used to guide data extraction and narrative analysis.ResultsWe retrieved 211 records and finally included 36 articles. Most of the evidence was from low-and middle-income countries with well-established CHW programmes. Evidence from CHW programmes initiated during pandemics and for CHW involvement in pandemic response in high-income countries was scant. CHW roles and tasks change substantially during pandemics. Clear guidance, training for changed roles and definition of what constitutes essential activities (ie, those that must to be sustained) is required. Most common additional activities during pandemics were community awareness, engagement and sensitisation (including for countering stigma) and contact tracing. CHWs were reported to be involved in all aspects of contact tracing - this was reported to affect routine service delivery. CHWs have often been stigmatised or been socially ostracised during pandemics. Providing PPE, housing allowance, equal training opportunities, transportation allowance, improving salaries (paid on time and for a broad range of services) and awards in high-profile public events contributed to better recruitment and retention. We also created inventories of resources with guiding notes on guidelines for health workers (n=24), self-isolation in the community (n=10) and information, education and counselling materials on COVID-19 (n=16).ConclusionsCHWs play a critical role in pandemics. It is important to ensure role clarity, training, supportive supervision, as well as their work satisfaction, health and well-being. More implementation research on CHWs in pandemics is required.
Characteristics and attitudes of first round invitees in the Irish National Colorectal Cancer Screening Programme
Authors: O'Reilly Susanne M , Hughes Katie N , Mooney Therese , Fitzpatrick Patricia , O'Donoghue Diarmuid , McNally Sara , Codd Mary , Ryan Elizabeth , Doherty Glen , Mason Olivia , Mulcahy Hugh E , Cullen Garret 
Published: June 2020

Background/objectiveColorectal cancer (CRC) screening is proven to reduce CRC-related mortality. Faecal immunochemical testing (FIT)-positive clients in the Irish National CRC Screening Programme underwent colonoscopy. Round 1 uptake was 40.2%. We sought to identify barriers to participation by assessing knowledge of CRC screening and examining attitudes towards FIT test and colonoscopy.MethodsQuestionnaires based on a modified Champion’s Health Belief Model were mailed to 3500 invitees: 1000 FIT-positive, 1000 FIT-negative and 1500 non-participants. 44% responded: 550 (46%) FIT-positive, 577 (48%) FIT-negative and 69 (6%) non-responders (NR).Results25% of respondents (n=286) did not perceive a personal risk of cancer, did not perceive CRC to be a serious disease and did not perceive benefits to screening. These opinions were more likely to be expressed by men (p=0.035). One-fifth (n=251) found screening stressful. Fear of cancer diagnosis and test results were associated with stress. FIT-positive clients, women and those with social medical insurance were more likely to experience stress.ConclusionsThe CRC screening process causes stress to one-fifth of participants. Greater use of media and involvement of healthcare professionals in disseminating information on the benefits of screening may lead to higher uptake in round 2.
Intracranial aneurysms in microcephalic primordial dwarfism: a systematic review
Authors: Monteiro Andre , Cortez Gustavo M , Granja Manuel F , Agnoletto Guilherme J , Kranich Julia , Padilha Marcus Vinicius R , Aldana Philipp , Hanel Ricardo 
Published: June 2020

BackgroundMicrocephalic primordial dwarfism (MPD) is a heterogeneous group of rare disorders. Recent studies have reported a significant percentage of patients with MPD suffering from a spectrum of cerebrovascular abnormalities, including intracranial aneurysms (IAs) and moyamoya syndrome. The neurological literature has not as yet specifically assessed IAs in this population. This systematic review aimed to assess the clinical behavior, characteristics, treatment modalities and outcomes of IAs in patients with MPD.MethodsWe performed a systematic search in PubMed, Ovid MEDLINE and Ovid EMBASE for cases of MPD with IAs. We included three illustrative cases from our institution.ResultsTwenty-four patients with 71 aneurysms were included in this study. Twelve patients (50%) presented with subarachnoid hemorrhage. The majority of patients were aged ≤18 years (70.8%), with a mean age of 16.2 years at presentation. Median aneurysm size was 3 (IQR 1.8–6) mm, and the most frequent locations were the internal carotid (37.3%) and middle cerebral arteries (23.8%). Concomitant moyamoya disease was reported in nine (37.5%) patients. Median age of aneurysm detection in screened patients was significantly lower than in non-screened patients (P=0.02). Microsurgical clipping (55.3%) and endovascular coiling (26.3%) were the most used modalities. Twenty-two cases were managed conservatively. Overall, mortality occurred in 45.8% of cases.ConclusionsScreening for cerebrovascular disease seems reasonable and effective to detect aneurysms at an earlier age in this population. Efforts in the literature to emphasize early and regular screening for these patients can positively impact outcomes in this population, however more evidence is needed.
A network of superconducting gravimeters as a detector of matter with feeble nongravitational coupling
Authors: Hu Wenxiang , Lawson Matthew M. , Budker Dmitry , Figueroa Nataniel L. , Kimball Derek F. Jackson , Mills Allen P. , Voigt Christian 
Published: June 2020

Abstract

Hidden matter that interacts only gravitationally would oscillate at characteristic frequencies when trapped inside of Earth. For small oscillations near the center of the Earth, these frequencies are around 300 μHz. Additionally, signatures at higher harmonics would appear because of the non-uniformity of Earth’s density. In this work, we use data from a global network of gravimeters of the International Geodynamics and Earth Tide Service (IGETS) to look for these hypothetical trapped objects. We find no evidence for such objects with masses on the order of 1014 kg or greater with an oscillation amplitude of 0.1 re. It may be possible to improve the sensitivity of the search by several orders of magnitude via better understanding of the terrestrial noise sources and more advanced data analysis.

Graphical abstract
Atomic hydrogen interactions with small polycyclic aromatic hydrocarbons cations
Authors: Schlathölter Thomas , Mostafa Yahia , Kamman Amber , Dongelmans Arnold , Arribard Yann , Cazaux Stephanie , Hoekstra Ronnie 
Published: June 2020

Abstract

When exposed to a thermal beam of hydrogen atoms, gas-phase coronene cations C24H12+ can be sequentially hydrogenated. This process is accompanied by a gradual transition of the electronic structure from aromatic to aliphatic. The planar very stable coronene structure transforms into the significantly weaker corrugated structure, typical for aliphatic molecules. In this study, we have investigated the hydrogenation of 5 smaller polycyclic aromatic hydrocarbon cations using a combination of radiofrequency ion trapping with time-of-flight mass spectrometry. Anthracene (C14H10+), pyrene (C16H10+), triphenylene (C18H12+), tetracene (C18H12+) and 8-9-benzofluoranthene (C20H12+) only cover a small mass range, but differ in carbon/hydrogen ratio, number of outer-edge sites and overall structure. We have observed qualitatively similar initial hydrogenation patterns for all 5 molecular ions, with odd hydrogenation states being dominant. Strong quantitative differences in hydrogenation and in attachment-induced fragmentation were found. For the case of pyrene cations, we have also investigated exposure to atomic D. Clear lines of evidence for HD/D2 abstraction reactions of Eley–Rideal type were found, as previously observed for coronene cations.

Graphical abstract
p300-Mediated Acetylation of Histone Demethylase JMJD1A Prevents Its Degradation by Ubiquitin Ligase STUB1 and Enhances Its Activity in Prostate Cancer
Authors: Xu Songhui , Fan Lingling , Jeon Hee-Young , Zhang Fengbo , Cui Xiaolu , Mickle McKayla B. , Peng Guihong , Hussain Arif , Fazli Ladan , Gleave Martin E. , Dong Xuesen , Qi Jianfei 
Published: June 2020

Abstract

The androgen receptor (AR) pathway plays a central role in the development of castration-resistant prostate cancer (CRPC). The histone demethylase JMJD1A has been shown to regulate activities of AR and c-Myc transcription factors and promote prostate cancer progression. Here, we report that JMJD1A protein stability is controlled by the ubiquitin ligase STUB1. High levels of JMJD1A were strongly correlated with low STUB1 levels in human CRPC specimens. STUB1 inhibited AR activity, AR-V7 levels, and prostate cancer cell growth partly through degradation of JMJD1A. Furthermore, the acetyltransferase p300 acetylated JMJD1A at lysine (K) 421, a modification that recruits the BET family member BRD4 to block JMJD1A degradation and promote JMJD1A recruitment to AR targets. Increased levels of both total and K421-acetylated JMJD1A were observed in prostate cancer cells as they developed resistance to the AR antagonist enzalutamide. Treatment of prostate cancer cells with either p300 or BET inhibitors destabilized JMJD1A, and enzalutamide-resistant prostate cancer cells were more sensitive than parental cells to these inhibitors. Together, our findings identify a critical role for acetylation of JMJD1A in regulating JMJD1A stability and AR activity in CRPC. These newly identified mechanisms controlling JMJD1A protein stability provide potential druggable targets to encourage the development of additional therapies for advanced prostate cancer.

Significance:
Identification of mechanisms regulating JMJD1A protein stability reveals new strategies to destabilize JMJD1A and concomitantly inhibit AR activities as potential prostate cancer therapy.
Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery
Authors: Douville Nicholas J. , Surakka Ida , Leis Aleda , Douville Christopher B. , Hornsby Whitney E. , Brummett Chad M. , Kheterpal Sachin , Willer Cristen J. , Engoren Milo , Mathis Michael R. 
Published: June 2020

Background:
While postoperative myocardial injury remains a major driver of morbidity and mortality, the ability to accurately identify patients at risk remains limited despite decades of clinical research. The role of genetic information in predicting myocardial injury after noncardiac surgery (MINS) remains unknown and requires large scale electronic health record and genomic data sets.

Methods:
In this retrospective observational study of adult patients undergoing noncardiac surgery, we defined MINS as new troponin elevation within 30 days following surgery. To determine the incremental value of polygenic risk score (PRS) for coronary artery disease, we added the score to 3 models of MINS risk: revised cardiac risk index, a model comprised entirely of preoperative variables, and a model with combined preoperative plus intraoperative variables. We assessed performance without and with PRSs via area under the receiver operating characteristic curve and net reclassification index.

Results:

Among 90 053 procedures across 40 498 genotyped individuals, we observed 429 cases with MINS (0.5%). PRS for coronary artery disease was independently associated with MINS for each multivariable model created (odds ratio=1.12 [95% CI, 1.02–1.24],
P
=0.023 in the revised cardiac risk index-based model; odds ratio, 1.19 [95% CI, 1.07–1.31],
P
=0.001 in the preoperative model; and odds ratio, 1.17 [95% CI, 1.06–1.30],
P
=0.003 in the preoperative plus intraoperative model). The addition of clinical risk factors improved model discrimination. When PRS was included with preoperative and preoperative plus intraoperative models, up to 3.6% of procedures were shifted into a new outcome classification.

Conclusions:
The addition of a PRS does not significantly improve discrimination but remains independently associated with MINS and improves goodness of fit. As genetic analysis becomes more common, clinicians will have an opportunity to use polygenic risk to predict perioperative complications. Further studies are necessary to determine if PRSs can inform MINS surveillance.
Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study
Authors: Oshunbade Adebamike A. , Yimer Wondwosen K. , Valle Karen A. , Clark Donald , Kamimura Daisuke , White Wendy B. , DeFilippis Andrew P. , Blaha Michael J. , Benjamin Emelia J. , O'Brien Emily C. , Mentz Robert J. , Fox Ervin R. , O'Mara Charles S. , Butler Javed , Correa Adolfo , Hall Michael E. 
Published: June 2020

Background
Blacks are disproportionately affected by stroke compared with whites; however, less is known about the relationship between stroke and cigarette smoking in blacks. Therefore, we evaluated the relationship between cigarette smoking and all incident stroke in the JHS (Jackson Heart Study).

Methods and Results
JHS participants without a history of stroke (n=4410) were classified by self‐reported baseline smoking status into current, past (smoked at least 400 cigarettes/life), or never smokers at baseline (2000–2004). Current smokers were further classified by smoking intensity (number of cigarettes smoked per day [1–19 and ≥20]) and followed up for incident stroke (through 2015). Hazard ratios (HRs) for incident stroke for current and past smoking compared with never smoking were estimated with adjusted Cox proportional hazard regression models. After adjusting for cardiovascular risk factors, the risk for stroke in current smokers was significantly higher compared with never smokers (HR, 2.48; 95% CI, 1.60–3.83) but there was no significant difference between past smokers and never smokers (HR, 1.10; 95% CI, 0.74–1.64). There was a dose‐dependent increased risk of stroke with smoking intensity (HR, 2.28 [95% CI, 1.38–3.86] and HR, 2.78 [95% CI, 1.47–5.28] for current smokers smoking 1–19 and ≥20 cigarettes/day, respectively).

Conclusions
In a large cohort of blacks, current cigarette smoking was associated with a dose‐dependent higher risk of all stroke. In addition, past smokers did not have a significantly increased risk of all stroke compared with never smokers, which suggests that smoking cessation may have potential benefits in reducing the incidence of stroke in blacks.
The WIPO-WTO Relationship
Authors: Gagliani Gabriele 
Published: June 2020

Abstract
The current, prevailing narrative on the WIPO-WTO relationship refers to “forum-shifting”. The idea is that developed countries moved from WIPO to WTO in order to obtain stronger IP protection at the international level by joining trade talks with IP negotiations. As a result, WTO would have become the main international forum for trade-related IP issues. This paper argues that the forum-shifting narrative, despite its merits, may fail to catch the complexity of WIPO-WTO relationship. Moreover, long-standing issues, as well as recent developments in trade and IP, demonstrate that the two Organizations have been characterized by continuity and constitute in reality interdependent, complementary fora. This is not to deny the differences existing between WIPO and WTO nor to discard the merits of the forum-shifting theory. Nonetheless, it is argued, it is time to move beyond it in order to grasp the implications of the WIPO-WTO relationship towards future international economic governance.
A 250-item list of Old Chinese vocabulary in the Baxter-Sagart reconstruction
Authors: SAGART Laurent , MA Kun 
Published: June 2020

Abstract
A 250-concept list was established for the purposes of an ongoing lexically-based study of Sino-Tibetan. This paper supplies the Old Chinese version of the list, in the Old Chinese reconstruction of Baxter and Sagart 2014. Chinese words attested in pre-Han times were selected based on their meaning as given in major lexica such as the Hànyǔ Dà Zìdiǎn. At times more than one OC item was found to match a concept in the list without it being clear which of the terms was the oldest. In such cases all the candidates were retained. As a result, the Old Chinese version of the list contains 301 words.
Here’s a Good Book: Hints on Writing a Book Review for Academic Journals
Authors: Lewis Marilyn Nesta 
Published: June 2020

Book reviews appear in journals for language teachers, alongside research-based articles and state-of-the art reviews. Interestingly, however, although editorial guidelines are usually provided for writers of articles, suggestions to book reviewers on how to write are harder to find. Similarly, in advice about academic writing for publishing, the genre of book reviews has received very little attention. This short article addresses a number of questions on the topic of writing book reviews.
Clinical outcomes associated with retrograde arterial perfusion in minimally invasive mitral valve surgery: a systematic review
Authors: Burns Daniel JP , Birla Rashmi , Vohra Hunaid A 
Published: June 2020

Introduction: Given several reports of an increased neurologic risk with retrograde arterial perfusion in minimally invasive mitral valve surgery, we sought to identify and synthesize the best available evidence on the influence of perfusion strategy on post-operative clinical outcomes in this population. Methods: A systematic search of PubMed, EMBASE, MEDLINE, and Cochrane library databases was performed to identify publications comparing clinical outcomes associated with antegrade and retrograde arterial perfusion in minimally invasive mitral valve surgery. Pre-specified outcomes of interest were neurologic events, mortality, and renal failure. The search was performed by two independent reviewers, with data abstraction following. Results: Seven observational studies were included in this review, with a total patient population of 5,385. Six were retrospective cohort in design, with a single small prospective cohort study identified. When available, adjusted publication-specific risk estimates were abstracted and included preferentially over unadjusted or reviewer-derived risk estimates. Meta-analysis was felt to be heavily flawed in the context of few small studies identified and was not performed. In adjusted estimates, there appeared to be an increased risk of neurologic complications with retrograde arterial perfusion. There was a null pattern apparent between arterial perfusion strategy and each of 30-day mortality and renal failure. Conclusion: Retrograde arterial perfusion in minimally invasive mitral valve surgery may be associated with an increased risk of neurologic events, without affecting the risk of 30-day mortality or renal failure. Although these patterns were identified, an overall paucity of evidence justifies further study.
Comparison of efficacy of a supervised versus non-supervised physical therapy exercise program on the pain, functionality and quality of life of patients with non-specific chronic low-back pain: a randomized controlled trial
Authors: Matarán-Peñarrocha Guillermo A , Lara Palomo Inmaculada Carmen , Antequera Soler Eduardo , Gil-Martínez Esther , Fernández-Sánchez Manuel , Aguilar-Ferrándiz María Encarnación , Castro-Sánchez Adelaida María 
Published: June 2020

Objective: To compare the effectiveness of supervised physical therapy program versus non-supervised on pain, functionality, fear of movement and quality of life in patients with non-specific chronic low back pain. Design: A randomized double-blind clinical trial. Setting: Clinical outpatient unit; home. Subjects: A total of 64 participants with non-specific chronic low back pain were randomized into either supervised exercise group ( n = 32) or non-supervised home exercise group ( n = 32). Interventions: The supervised group was treated with therapy exercises (strengthen lumbopelvic musculature), while the non-supervised received an informative session of the exercises, which were performed un-supervised at home. Both groups received three weekly sessions for eight weeks. Main Measures: Pain, disability, fear of movement, quality of life, trunk muscle endurance and trunk anteflexion motion were assessed at baseline, two, and six months of follow-up. Results: Although analysis of variance (ANOVA) test showed statistically significant differences between groups for pain ( P = 0.028; supervised: 2.5 ± 2.1; non-supervised: 3.5 ± 1.5) and disability for Roland–Morris Disability Questionnaire ( P = 0.004; supervised: 3.1 ± 2.2; non-supervised: 5.1 ± 3.0) and for Oswestry Disability Index ( P = 0.034; supervised: 14.5 ± 7.1; non-supervised: 19.2 ± 10.0) at 8 weeks immediately posttreatment, there were no differences between the groups in patient-rated pain, functionality, fear of movement and quality of life at six months of follow-up. Conclusion: Patients with chronic low back pain who received supervised exercise showed more improvement in both the short and long term in all patient-rated outcomes over the non-supervised group, but the differences were small and not clinically significant.