bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact De Lâ€™anthropisation Sur Les Variations SpatioTemporelles Et Du Peuplement Zooplanctonique: Exemple Des Retenues Dâ€™eau De Bongouanou (Afrique De Lâ€™ouest, CoteDâ€™ivoire)
Authors: Mamadou Fofana Nahon , Nâ€™doua Etile Raphael , Yao Konan Aristide , Silvain Yao Stanislas , Goore Bi Gouli 
Published: November 2020

Cette Ã©tude vise Ã dÃ©terminer lâ€™impact de lâ€™anthropisation sur les variations spatiotemporelles et du peuplement zooplanctonique des lacs Ehuikro et SocotÃ¨ situÃ©s au Centre-Est de la CÃ´te d'Ivoire dans la rÃ©gion du Moronou. Le zooplancton a Ã©tÃ© Ã©chantillonnÃ© mensuellement dâ€™avril 2017 Ã Mars 2018 Ã lâ€™aide dâ€™un filet Ã plancton de 60 Âµm de vide de maille. Au total 37 taxons ont Ã©tÃ© observÃ©s (24 RotifÃ¨res, 6 CopÃ©podes, 3 CladocÃ¨res et 4 autres organismes). Les RotifÃ¨res constituent le groupe dominant et constituent 46 % de lâ€™abondance totale. En termes de densitÃ©, les RotifÃ¨res sont largement dominÃ©s par les Brachionidae (51 %). Globalement, la richesse taxonomique et lâ€™abondance les plus fortes ont Ã©tÃ© enregistrÃ©es pendant les saisons de pluies (54 %) contre 46 % en saisons sÃ¨ches. La station Ehui 2 a eu la plus grande richesse taxonomique (26 taxons en saisons sÃ¨ches et 25 taxons en saisons des pluies) et la station Soco 1 a donnÃ© 17 taxons en saisons sÃ¨ches et pluvieuses. Les variables qui influencent fortement la diversitÃ© taxonomique et lâ€™abondance sont: la conductivitÃ©, la tempÃ©rature, le potentiel dâ€™hydrogÃ¨ne, la teneur en solide dissout, la teneur en phosphore, la teneur en nitrate et la profondeur.
Objectives: This study aims to determine the impact of anthropization on Spatio-temporal variations and zooplankton population of lakes Ehuikro and SocotÃ¨ located in the center-east of CÃ´te d'Ivoire in the region of Moronou. Method and results: Zooplankton was sampled monthly from April 2017 to March 2018 using a 60 Âµm mesh void plankton net. A total of 37 taxa were observed (24 Rotifers, 6 Copepods, 3 Cladocerans and 4 other organisms). Rotifers are the dominant group with (46%) of the total abundance. In terms of density, Rotifers are largely dominated by Brachionidae (51%). Globally, the highest taxonomic richness and abundance were recorded during the rainy seasons at 54% against 46% in the dry seasons. Ehui 2 station had the greatest taxonomic richness (26 taxa in dry seasons and 25 taxa in rainy seasons) and Soco 1 station gave 17 taxa in dry and rainy seasons. The variables strongly influencing taxonomic diversity and abundance are: conductivity, temperature, hydrogen potential, rate of dissolved solids, rate of phosphorus, rate of nitrate and depth.
Evaluation de lâ€™effet de la poudre des feuilles de Moringa oleifera sur les parasites gastrointestinaux du lapin domestique (Oryctolagus cuniculus) au BÃ©nin
Authors: Boni Saka Konmy Basile , Abiodoun OlounladÃ© Pascal , Doko-Allou Sanni-yo , Bertrand Azando Erick Virgile 
Published: November 2020

En Afrique subsaharienne et au BÃ©nin, peu de travaux ont Ã©tÃ© consacrÃ©s au traitement des maladies du lapin. Dans le but dâ€™amÃ©liorer le schÃ©ma thÃ©rapeutique des lapins dont lâ€™importance est considÃ©rable dans cette zone, une attention particuliÃ¨re est accordÃ©e Ã Moringa oleifera pour ses vertus nutritionnelles et pharmacologiques. Une Ã©tude phytochimique et antiparasitaire a donc Ã©tÃ© entreprise Ã cet effet. Le criblage phytochimique et lâ€™analyse quantitative ont rÃ©vÃ©lÃ© la prÃ©sence et la haute teneur de grands groupes de composÃ©s chimiques Ã activitÃ© antiparasitaire comme les phÃ©nols totaux (384.09mgGAE/50g), flavonoÃ¯des (0,019mgRE/50g), tanins (9,60.10- 6mgCE/50g) saponosides, dÃ©rivÃ©s quinoniques. Trois rations alimentaires granulÃ©es Ã base de feuilles de Moringa oleifera (0, 5, 10 et 15% dâ€™incorporation) ont Ã©tÃ© testÃ©es sur les parasites gastrointestinaux des lapins. Lâ€™Ã©tude parasitologique effectuÃ©e par coproscopie quantitative a permis de montrer que les rations alimentaires de 5%, 10% et 15% dâ€™incorporation ont Ã©tÃ© efficaces Ã hauteur de 97,58 % et 97,57% sur les oocystes de coccidies ; 97,74 et 99,04 sur les Å“ufs dâ€™helminthes de lapins selon les mÃ©thodes de POWER et de COLES. Cette Ã©tude justifie donc lâ€™utilisation traditionnelle des feuilles de Moringa oleifera pour le traitement des parasitoses gastrointestinales des lapins.
In sub-Saharan Africa and Benin, little work has been devoted to the treatment of rabbit diseases. For improving the rabbitâ€™s treatment whose importance is considerable in this region, special attention is given to Moringa oleifera for its nutritional and pharmacological properties. Phytochemical and anthelmintic studies were therefore undertaken to this effect. Phytochemical screening and quantitative analysis revealed the presence and the high content of large groups of chemical compounds with anthelmintic activity such as total phenols (384.09mgGAE/50g), flavonoids (0.019mgRE/50g), tannins (9.60.10-6 mgCE/50g), saponins, and quinone derivatives. The formulation of three granulated rations containing incorporation 5, 10 and 15% of powdered leaves of Moringa oleifera has been tested on gastrointestinal nematodes of rabbits. The parasitological study by quantitative coproscopy has shown that the granulated food ration with incorporation of 15% leaf powder of Moringa oleifera is effective on gastrointestinal parasites up to 97.58 % and 97.57% on oocysts of coccidia, 97.74 and 99.04 on helminth eggs of rabbits calculated by the POWER and COLES methods. This study has justified the traditional use of Moringa oleifera leaves for the treatment of gastrointestinal parasite of rabbits.
Induced pluripotent stem cells derived brain endothelial cells from patients suffering from familial form of Alzheimer’s disease display impaired barrier function and cell metabolism
Authors: Raut Snehal , Patel Ronak , Al-Ahmad Abraham 
Published: November 2020

Abstract
Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disease. It is an irreversible condition marked by irreversible cognitive loss, commonly attributed to the loss of hippocampal neurons due to the formation of senile plaques and neurofibrillary tangles. Although the sporadic form is the most prevalent, the presence of familial form (involving several genes such as APP, PSEN1 and PSEN2) of the disease is commonly used as a model for understanding the pathophysiology of the disease. The aim of this study is to investigate the effect of mutation on PSEN1 and PSEN2 genes on the BBB function using induced pluripotent stem cells (iPSCs).Methods: iPSC lines from patients suffering from familial form of Alzheimer’s disease and harboring mutations in PSEN1 or PSEN2 were used in this study and compared to a control iPSC line. Cells were differentiated into brain microvascular endothelial cells (BMECs) following established differentiation protocols. Barrier function was assessed by measuring TEER and fluorescein permeability, drug transporters activity was assessed by uptake assay, glucose uptake and metabolism assessed by cell flux analyzer, mitochondrial potential by JC-1 and lysosomal acidification by acridine orange. Results: iPSC derived BMECs from the FAD patient presenting a mutation in PSEN1 gene showed impaired barrier function compared to the FAD patient harboring a mutation in PSEN2 and to control group. Such impaired barrier function correlated with poor tight junction complexes and reduced drug efflux pump activity. In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production. Finally, PSEN1- and PSEN2-BMECs showed an elevated secretion of Ab1-40 peptides compared to control-BMECs.Conclusion: Our study reports that iPSC-derived BMECs obtained from FAD patients showed impaired barrier properties and BMECs metabolism. In particular, PSEN1 mutation was associated with a more detrimental phenotype than the PSEN2 mutation, as noted by a reduced barrier function, reduced drug efflux pump activity and diminished glucose metabolism. Therefore, assessing the contribution of genetic mutations associated with Alzheimer’s disease will allow us to better understand the contribution of the BBB in dementia, but also other neurodegenerative diseases.
Vaccination Dropout Rates Among Children Aged 12-23 Months in the Urban-Rural Health District of Mont Ngafula II, Democratic Republic of the Congo: A Cross-sectional Study
Authors: Kayembe-Ntumba Harry-César , Vangola Felly , Ansobi Papy , Bokabo Eric , Mandja Bien-Aimé , Bompangue Didier 
Published: November 2020

Abstract
Background: Globally, 1.8 million children failed to receive the 3-dose diphtheria, tetanus and pertussis (DTP) series every year in the Democratic Republic of the Congo (DRC). Currently, an emergency plan targeting 9 provinces, including the capital of Kinshasa, is launched to reinforce routine immunization. The Mont Ngafula II health district (HD) was the only one to report high vaccination dropout rates over almost five consecutive years. This study aimed to assess issues within the local dynamic system of vaccination services and identify associated risk factors among children aged 12-23 months. Methods: A cross-sectional household survey was conducted among 418 children in June-July 2019 using a two-stage sampling design. Socio-demographic and perception data were collected through a structured interviewer-administered questionnaire. The distribution of 2017-2018 immunization coverage and dropout rate was extracted from local authority of HD and mapped. Chi-square test and multivariate logistic regression were used to identify predictors of high vaccination dropout. Statistical significance was defined as p < 0.05. Results: Of 14 health areas included in the Mont Ngafula II HD, four reported high vaccine coverage, only one recorded low vaccine coverage and three registered both low vaccine coverage and high dropout rate. Multivariate logistic regression showed the predictors of immunization dropout as follows: no possession of immunization card (aOR = 2.49; 95% CI = 1.25-4.93; p = 0.010), living in rural areas (aOR = 1.53; 95% CI = 1.02-2.32; p = 0.042), unavailability of seating places (aOR = 7.10; 95% CI = 1.39-36.27; p = 0.019), no respect of the order of arrival (aOR = 3.88; 95% CI = 1.48-10.16; p = 0.006) during vaccination in health facilities, and the lack of a reminder system on days before the scheduled vaccination (aOR = 2.17; 95% CI = 1.43-3.32; p < 0.001). Conclusion: The poor utilization of immunization services seemed as the main health concern followed by the poor access. Residing in rural areas, no immunization card possession, absence of seating places, no respect of the order of arrival, and the lack of a reminder system were the predictors of vaccination dropout rates. These results advocate for prioritizing targeted interventions and programs that will strengthen interpersonal communication between vaccination service providers and users during vaccination in health facilities as well as implement and extend a reminder system using SMS reminders on days before the scheduled vaccination.
Electric Scooter - An Alternative Mode of Transportation for Malaysian Youth
Authors: Mamun Abdullah Al , Zainol Noor Raihani , Hayat Naeem 
Published: November 2020

Abstract
Background: This study examined the effect of environmental concern, knowledge, attitude, subjective norms, perceived behavioural control, attributes of interest, and monetary benefit on the willingness to purchase and actual purchase of electric scooter (ES) among Malaysian youth. This study adopted a cross-sectional design and collected quantitative data from 1,306 youth by sharing a Google form link through social media. Results: The findings reveal that environmental concern and environmental knowledge have a significant positive effect on attitude towards ES. Findings also show that attitude towards ES, subjective norms, perceived behavioural control, attributes of interest, and monetary benefit have a significant positive effect on the willingness to purchase and actual purchase of ES. Findings reveal the positive and significant mediating effect of attitude towards ES and the willingness to purchase ES. The multi-group analysis revealed that the effect of attitude towards willingness was significantly higher among the urban respondents. Moreover, the effect of environmental concern on attitude towards ES among rural respondents was significantly higher than urban respondents. In contrast, the effect of environmental knowledge on attitude towards ES among urban respondents was significantly higher than rural respondents. Conclusions: The environmental and transportation policymakers should focus on highlighting the attributes of ESs and their environmental and monetary benefits to promote the mass adoption of ESs among Malaysian youth. Offering subsidies like no road tax and zero import duty and reducing the production of combustion-based two-wheelers are among the options to facilitate the adoption of ES among Malaysian youth. The adoption of ES is socially promoted to reduce the use of conventional two-wheelers. Another relevant area that needs attention is the charging outlet or fuel stations for ES. The adoption of ES remains low if there is a lack of charging or fuel stations.
Identification and Validation of an RNA Binding Proteins-Associated Prognostic Signature for Non-Small Cell Lung Cancer
Authors: Miao Ti-wei , Chen Fang-ying , Xiao Wei , Du Long-yi , Mao Bing , Wang Yan , Fu Juan-juan 
Published: November 2020

Abstract
Background: Non-small cell lung cancer (NSCLC) is a malignancy with relatively high incidence and poor prognosis. RNA-binding proteins (RBPs) were reported to be dysregulated in multiple cancers and were closely associated with tumor initiation and progression. However, the functions of RBPs in NSCLC remain unclear. Method: The RNA sequencing data and corresponding clinical information of NSCLC was downloaded from The Cancer Genome Atlas (TCGA) database. We identified aberrantly expressed RBPs between tumor and control tissue, and systemically investigated the expression and prognostic value of these RBPs by a series of bioinformatics analysis.Results: A total of 459 aberrantly expressed RBPs (291 up-regulated and 168 down-regulated RBPs) were identified. Functional enrichment analysis indicated that the differentially expressed RBPs were mainly associated with RNA splicing, ncRNA metabolic process, regulation of translation, mRNA surveillance pathway, RNA degradation, and RNA transport. Thirteen RBPs (ZC3H12C, ZC3H12D, BOP1, CASC3, DDX24, IGF2BP1, KHDC1, FASTKD3, TARBP1, INTS7, NOL12, SNRPB, PABPC1L) were identified as prognostic RBPs by multivariate Cox regression analysis, and were used to construct a prognostic signature. Further analysis demonstrated that high-risk group were significantly related to poor overall survival in training and testing cohort. The area under receiver operator characteristic curve of the prognostic signature was 0.703 in training cohort and 0.636 in testing cohort. In addition, the prognostic signature was further validated in differently clinical subgroup (>=65, <65, female, male, stage I-II, III- IV, T1-2, T3-4, N0, N1-3, M0 and M1). The risk score was an independent prognostic factor of NSCLC. A nomogram based on thirteen RBPs was constructed to predict the survival of patients.Conclusion: Our results provide novel insights into the pathogenesis of NSCLC. The RBPs-associated prognostic signature showed predictive value for NSCLC prognosis, with potential applications in clinical decision-making and individualized treatment.
Human Epididymis Protein 4 expression in the renal cortex tissue is an independent prognostic factor in patients with renal cell carcinoma
Authors: Noguchi Go , Jikuya Ryosuke , Miyagi Yohei , Nakamura Yoshiyasu , Ohtake Shinji , Shibata Yosuke , Suzuki Takahisa , Osaka Kimito , Umemoto Susumu , Nagashima Yoji , Yokose Tomoyuki , Kishida Takeshi , Yao Masahiro , Nakaigawa Noboru 
Published: November 2020

Abstract
Background: Human epididymis protein 4 (HE4) has been indicated as a novel tumor marker for ovarian cancer diagnosis/monitoring and as a mediator of renal fibrosis. In this study, we investigated the potential role of HE4 in the pathogenesis of patients with renal cell carcinoma (RCC). Methods: We retrospectively enrolled 249 patients with RCC who underwent nephrectomies at a single center between 1997 and 2010. HE4 expression was evaluated by immunohistochemistry and RNA in situ hybridization staining in both tumor and renal cortex tissue microarrays. The expression of HE4 was evaluated in line with the clinicopathologic features of each patient. Results: HE4-positive staining was confirmed in 37 (15.0%) tumor tissue microarrays and in 88 (38.3%) cortex tissue microarrays. High expression of HE4 in the tumor was not associated with overall survival (OS), cancer-specific survival (CSS), or recurrence free survival (RFS). However, high expression of HE4 in the renal cortex was strongly associated with an increased risk of OS, CSS, and RFS (HR 3.608 (95% confidence interval (CI) 2.127-6.118); p<0.001, HR 5.759 (95% CI 2.801-11.841); p<0.001 and HR 3.309 (95% CI 1.751-6.252); p<0.001, respectively). Multivariate analysis revealed that the Eastern Cooperative Oncology Scale of Performance Status (ECOG-PS), stage, pathological subtype, and high expression of HE4 in the renal cortex were independent risk factors for poor OS and that ECOG-PS, tumor size, stage, and high expression of HE4 in the renal cortex were independent risk factors for poor CSS. Conclusions: High expression of HE4 in the renal cortex is an independent risk factor of OS and CSS in RCC. Further investigations are needed to elucidate the underlying mechanisms of HE4 in the renal cortex in the progression of renal cell carcinoma.
Quantum Go Machine
Authors: Qiao Lu-Feng , Gao Jun , Jiao Zhi-Qiang , Zhang Zhe-Yong , Cao Zhu , Ren Ruo-Jing , Zhang Chao-Ni , Hu Cheng-Qiu , Xu Xiao-Yun , Tang Hao , Ma Zhi-Hao , Jin Xian-Min 
Published: November 2020

Abstract
Go has long been considered as a testbed for artificial intelligence. By introducing certain quantum features, such as superposition and collapse of wavefunction, we experimentally demonstrate a quantum version of Go by using correlated photon pairs entangled in polarization degree of freedom. The total dimension of Hilbert space of the generated states grows exponentially as two players take turns to place the stones in time series. As nondeterministic and imperfect information games are more difficult to solve using nowadays technology, we excitedly find that the inherent randomness in quantum physics can bring the game nondeterministic trait, which does not exist in the classical counterpart. Some quantum resources, like coherence or entanglement, can also be encoded to represent the state of quantum stones. Adjusting the quantum resource may vary the average imperfect information (as comparison classical Go is a perfect information game) of a single game. We further verify its non-deterministic feature by showing the unpredictability of the time series data obtained from different classes of quantum state. Finally, by comparing quantum Go with a few typical games that are widely studied in artificial intelligence, we find that quantum Go can cover a wide range of game difficulties rather than a single point. Our results establish a paradigm of inventing new games with quantum-enabled difficulties by harnessing inherent quantum features and resources, and provide a versatile platform for the test of new algorithms to both classical and quantum machine learning.
Assessment of Level of HIV/AIDS Preventive Self-Efficacy and Associated Factors Among Regular Undergraduate Students of Madda Walabu University, Southeast Ethiopia, 2020. A Cross-Sectional Study
Authors: Kene Chala , Adugna Haweni , Lemessa Kalkidan , Deribe Leul 
Published: November 2020

Abstract
Background: Self-efficacy for HIV prevention is described as a person’s belief in his/her capacity to carry out necessary actions to perform a specific behavior for HIV prevention. This study aimed to assess level of HIV/AIDS preventive self-efficacy and associated factors among regular undergraduate students of Madda Walabu University, Southeast Ethiopia, 2020. Methods: Cross-sectional study was conducted from February 15 to 20, 2020. Four hundred forty-two study participants were selected using simple random sampling technique. Data was entered to Epi Data version 4.6.0.2 and analyzed using SPSS version 26 software. Bivariate and multivariable logistic regression model was fitted to identify factors associated with HIV/AIDS preventive self-efficacy. Odds ratio with 95% confidence interval was computed and p value less than 0.05 was used to determine the level of significance. Result: The mean level of HIV/AIDS preventive self-efficacy among regular undergraduate students of Madda Walabu University was found to be 74.58+19.98. Being female [AOR=1.76(1.04-2.81)], in field of health science [AOR= 1.92(1.10-3.36)], second year of study [AOR=2.77(1.55-4.94)] and drinking alcohol [AOR=2.9(1.61- 5.23)] were found to be factors associated with higher HIV/AIDS preventive self-efficacy. Whereas, exposed to pornography [AOR=0.53(0.33-0.85)] was found to be factor associated with lower HIV/AIDS preventive self-efficacy.Conclusion: The mean HIV /AIDS preventive self-efficacy of the participants in this study area were found to be low. Sex, field and year of study, drinking alcohol and ever had watched pornography were factors found to be significantly associated with HIV/AIDS preventive self-efficacy. Staffs should be cooperative in educating their students to boost their self-efficacy.
Quantitative determination of the shock stage of L6 ordinary chondrites using X-ray diffraction
Authors: Imae Naoya , Kimura Makoto 
Published: November 2020

Abstract
The shock stages of 14 L6 ordinary chondrites are estimated using the random X-ray diffraction patterns of polished thin section samples and the in-plane rotation method. The mean lattice strains and grain size factors for olivine and orthopyroxene are determined from the analyses based on the Williamson–Hall plots, which depict the tangent Bragg angle and integral breadth β. The lattice strain in olivine, eOl, is distributed from ~0.05% to ~0.25%, while that in orthopyroxene, eOpx, is distributed from ~0.1 to ~0.4%, where we selected the isolated peaks of olivine and orthopyroxene. The olivine peaks have Miller indices of (130), (211), (222), and (322), while the orthopyroxene peaks have Miller indices of (610), (511), (421), (631), and (12.1.2). The intercept for integral breadth β0O1 and β0Opx for the Williamson–Hall plots correlates with the grain size of the constituent minerals. The grain size is proportional to the inverse of β0 since the β intercept increases with the shock stage. Introducing a new parameter, –ε/log β0 for olivine (0.04–0.16) and orthopyroxene (0.07–0.32) reveals a clear relationship between them: –εOpx/log β0Opx = –0.01+ 2.0 (–εOl/log β0O1) (R &gt; 0.9). In addition, the isolated peak of plagioclase (201) systematically changes as the shock stage increases, suggesting the progress of amorphization (maskelynitization). Another parameter, (I/FWHM)Pl(201) reveals additional relationships: –εOl/log β0O1 = 0.14(±0.01) − 5.2 × 10−5 (±5.7 × 10−6) × (I/FWHM)Pl(201), and –εOpx/log β0Opx = 0.25(±0.04) − 8.9 × 10−5 (±2.6 × 10−5) × 10–5 × (I/FWHM)Pl(201). These three parameters systematically change with the shock stage, suggesting that they are suitable shock barometers. The present method is useful to evaluate the shock stage of L6 chondrites and potentially enables quantitative shock stage classification for stony meteorites.