bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Tingkat Kerusakan Jalan Menggunakan Metode Bina Marga (Studi Kasus Jalan Ujung Beurasok STA 0+^000 S/D STA 0+^700)
Authors: Agusmaniza Roni , Fadilla Ferhan Dimas 
Published: April 2020

Abstrak: Pemanfaatan prasarana jalan sesuai dengan rencana pembangunan jalan, maka perlu dilakukan usaha-usaha pemeliharaan dan penanganan yang harus direncanakan dengan baik terhadap jalan yang rusak. Kerusakan jalan disebabkan antara lain oleh lalu lintas berulang, muatan berlebih, suhu udara, air serta mutu awal produk jalan yang jelek. Tujuan penilitian ini untuk mengetahui jenis kerusakan dan tingkat kerusakan jalan pada jalan Ujong Beurasok. Metode yang digunakan dalam penelitian ini adalah metode bina marga. Langkah awal penelitian ini menghitung lalu lintas harian rata-rata dan mengelompokkan data hasil survei sesuai dengan jenis kerusakan jalan. Selanjutnya menilai dan menjumlahkan setiap jenis kerusakan jalan. Lalu menetapkan nilai kondisi jalan dan menghitung nilai prioritas kondisi jalan. Hasil penelitian kerusakan jalan didapatkan jenis kerusakan jalan yaitu pelempasan butir sebanyak 11 buah dengan luas 4.185.924 cm2 (13,29%), retak kulit buaya sebanyak 13 buah dengan luas 353.185,5 cm2 (1,121%), retak pinggir sebanyak 3 buah dengan luas 104.400 cm2 (0,331%), retak memanjang sebanyak 1 buah dengan luas 2000 cm2 (0,006%), tambalan sebanyak 12 buah dengan luas 244.221 cm2 (0,775%) dan lubang sebanyak 14 buah dengan luas 193.293,74 cm2 (0,613%) dan volume 1.082.898,56 cm3. Dari hasil perhitungan Urutan Prioritas didapat nilai sebesar 8 menanda bahwa jalan Ujung Beurasok Kecamatan Johan Pahlawan STA 0+000 s/d 0+700 dapat dimasukan kedalam program pemeliharaan rutin. Kata kunci : Kerusakan Jalan, Metode Bina Marga Abstract : The utilization of road infrastructures in accordance with road development plans requires maintenance and handling efforts that must be planned well against the damaged roads. Road damage is caused by the repeated traffic, overload, air temperature, water, and the initial quality of the poor road product. This research aims to determine the type of damage and damage level of road on Ujong Beurasok Road. The method used in this research is the method of Bina Marga. The initial step of the study calculated average daily traffic and grouped the survey result data according to the type of road damage. Type of road damage are graded and summed. The road condition value is set, and the priority value of the road condition is calculated. The damagaes found are 11 sections of loose grain with an area 4.185.924 cm2 (13.29%), 13 sections of alligator cracking with an area of 353.185,5 cm2 (1.121%), 3 sections of cracked edges with an area of 104.400 cm2 (0.331%), 1 elongated crack with an area of 2000 cm2 (0.006%), 12 sections of patch with an area of 244,221 cm2 (0.775%) and 14 pieces of holes with an area of 193.293,74 cm2 (0.613%) and the volume of 1.082.898,56 cm3. The calculation of priority order obtained the value of 8 indicating that Beurasok Road of Johan Pahlawan district STA 0 + 000 S/D 0 + 700 should be considered in the routine maintenance program.Keywords: Road damage, Bina Marga method
Distribution of arbuscular mycorrhizal fungi (AMF) in Terceira and São Miguel Islands (Azores)
Authors: Melo Catarina , Walker Christopher , Freitas Helena , Machado Artur , Borges Paulo 
Published: April 2020

The data, presented here, come from samples collected during three research projects which aimed to assess the impact of land-use type on Arbuscular Mycorrhizal Fungi (AMF) diversity and community composition in pastures of Terceira Island (Azores, Macaronesia, Portugal) and also in the native forest of two Azorean Islands (Terceira and São Miguel; Azores, Macaronesia, Portugal). Both projects contributed to improving the knowledge of AMF community structure at both local and regional scales.
Little is known on the AMF communities from Azores islands and this study reports the first survey in two Azorean Islands (Terceira and São Miguel). A total of 18,733 glomeromycotan spores were classified at the species level from 244 field soil samples collected in three different habitat types – native forests (dominated by Juniperus brevifolia and Picconia azorica), semi-natural and intensively-managed pastures. Thirty-seven distinct spore morphotypes, representing ten glomeromycotan families, were detected. Species of the family Acaulosporaceae dominated the samples, with 13 species (38% of the taxa), followed by Glomeraceae (6 spp.), Diversisporaceae (4 spp.), Archaeosporaceae (3 spp.), Claroideoglomeraceae (3 spp.), Gigasporaceae (3 spp.), Ambisporaceae and Paraglomeraceae, both with the same number of AMF species (2 spp.), Sacculosporaceae (1 sp.) and Entrophospora (family insertae sedis). Members of the family Acaulosporaceae occurred almost exclusively in the native forests especially associated with the Picconia azorica rhizosphere, while members of Gigasporaceae family showed a high tendency to occupy the semi-natural pastures and the native forests of Picconia azorica. Members of Glomeraceae family were broadly distributed by all types of habitat which confirm the high ecological plasticity of this AMF family to occupy the more diverse habitats.
A database of the global distribution of alien macrofungi
Authors: Monteiro Miguel , Reino Luís , Schertler Anna , Essl Franz , Figueira Rui , Ferreira Maria , Capinha César 
Published: April 2020

Human activities are allowing the ever-increasing dispersal of taxa to beyond their native ranges. Understanding the patterns and implications of these distributional changes requires comprehensive information on the geography of introduced species. Current knowledge about the alien distribution of macrofungi is limited taxonomically and temporally, which severely hinders the study of human-mediated distribution changes for this taxonomic group.
Here, we present a database on the global alien distribution of macrofungi species. Data on the distribution of alien macrofungi were searched in a large number of data sources, including scientific publications, grey literature and online databases. The database compiled includes 1966 records (i.e. species x region combinations) representing 2 phyla, 7 classes, 22 orders, 82 families, 207 genera, 648 species and 31 varieties, forms or subspecies. Dates of introduction records range from 1753 to 2018. Each record includes the location where the alien taxon was identified and, when available, the date of first observation, the host taxa or other important information. This database is a major step forward to the understanding of human-mediated changes in the distribution of macrofungal taxa.
Diagnostic Value of Optical Spectral Transmission in Rheumatoid Arthritis: Associations with Clinical Characteristics and Comparison with Joint Ultrasonography
Authors: Triantafyllias Konstantinos , Heller Caroline , de Blasi Michele , Galle Peter Robert , Schwarting Andreas 
Published: April 2020

Objective.To examine the value of optical spectral transmission (OST) in detecting joint inflammation in patients with rheumatoid arthritis (RA) and to evaluate whether OST correlates with certain patient characteristics.Methods.OST measurements were performed in the metacarpophalangeal, proximal intraphalangeal, and wrist joints of 168 patients with RA and 114 controls. OST difference between the 2 groups was statistically examined and subsequently controlled for the effect of possible confounding factors. Diagnostic OST performance was tested by receiver-operating characteristics. Moreover, associations of OST with clinical and serological activity markers (patient group), joint ultrasound (US; patient subgroup) and various anthropometric and epidemiologic parameters (patient and control group) were evaluated by Spearman correlation coefficient and a generalized linear statistical adjustment model.Results.OST was significantly higher in the RA group than in the control group, even after adjustment for confounding factors (1.89; 95% CI 0.709–3.070, padj = 0.002). Taking US as a reference, area under the curve for all 1251 joints simultaneously was 0.67 (95% CI 0.631–0.709). In the patient group, correlation and adjustment analyses showed associations of OST with various disease activity markers [28-joint count Disease Activity Score (rho 0.313), swollen joint counts (rho 0.361), C-reactive protein (rho 0.389); all, padj = 0.001], age (rho 0.276, p < 0.001), and osteoarthritis (p = 0.022). Moreover, OST associated with a power Doppler US score (rho 0.442; p = 0.001) and a greyscale US score (rho 0.591; p < 0.001). In both groups males had significantly higher OST values than females and OST associated moderately weakly with body mass index (rho patients 0.316, rho controls 0.24; all, p < 0.001).Conclusion.Patients with RA showed higher OST values in comparison to controls. Moreover, OST associated with clinical, US, and laboratory disease activity markers.
Long-term Safety and Effectiveness of Tacrolimus in Patients With Lupus Nephritis: 5-year Interim Postmarketing Surveillance Study in Japan (TRUST)
Authors: Takeuchi Tsutomu , Wakasugi Naoko , Uno Satoshi , Makino Hirofumi 
Published: April 2020

Objective.To assess the long-term safety and effectiveness of tacrolimus for treating lupus nephritis (LN) in the real-world clinical setting.Methods.This is an ongoing, open-label, noncomparative, observational, postmarketing surveillance study conducted across 275 sites in Japan. Registered patients with LN were followed for 10 years. Here we report data relating to 5 years of tacrolimus maintenance therapy at the interim data cutoff in August 2016.Results.Of 1395 registered patients, 1355 received tacrolimus maintenance therapy for LN and provided safety data. The most common serious adverse drug reactions (ADR) included pneumonia (1.1%), herpes zoster (1.0%), cellulitis (1.0%), and diabetes mellitus (1.0%). ADR occurred mainly within the first 28 weeks of tacrolimus treatment, and no marked increase was observed during the follow-up period. Subgroup analyses suggested that risk factors for commonly observed ADR associated with tacrolimus included inpatient management, LN disease severity, increasing age, abnormal renal or hepatic function, and comorbid or previous disease. The cumulative rate of progression to renal failure (based on the attending physician’s assessment) was 0.8% at Year 1 and 6.6% at Year 5. Cumulative relapse rates were 7.8% and 30.6%, respectively. Urine protein:creatinine ratio, serum anti-dsDNA antibody levels, complement C3 levels, and steroid-sparing effects were all significantly improved from 4 weeks after tacrolimus treatment initiation (P < 0.001) and were sustained over 5 years.Conclusion.Long-term tacrolimus maintenance treatment over 5 years in the real-world clinical setting was well tolerated and effective in a large population of patients with LN (www.ClinicalTrials.gov: NCT01410747).
Advanced Chronic Kidney Disease in Lupus Nephritis: Is Dialysis Inevitable?
Authors: Tselios Konstantinos , Gladman Dafna D. , Su Jiandong , Urowitz Murray B. 
Published: April 2020

Objective.Advanced chronic kidney disease (CKD) carries an increased risk for progression to endstage renal disease (ESRD). We aimed to determine the rate of progression and the factors that drive the decline of renal function in lupus nephritis (LN).Methods.Patients with advanced LN-related CKD were identified from our longterm longitudinal cohort. Advanced CKD was defined as stage 3b [estimated glomerular filtration rate (eGFR) = 30–44 ml/min/1.73 m2] and stage 4 (eGFR = 15–29 ml/min/1.73 m2). All individuals were followed until progression to ESRD or the last visit and were divided into “progressors” and “non- progressors.” Demographic, clinical, immunological, and therapeutic variables were compared at baseline. Multivariable Cox regression analysis (both time-dependent and independent) was performed to identify predictors for progression.Results.One hundred eighteen patients (74 CKD 3b and 44 CKD 4) were included. Forty-five patients progressed (29 to ESRD and 16 from CKD 3b to CKD 4) after 6 years on average. No significant decline in the renal function was observed in 73 patients (“non-progressors”) after 10 years on average. Active serology (high anti-dsDNA titers and low complements C3/C4) at the time of CKD diagnosis and any increase of the daily prednisone dose after baseline were strongly associated with progression. Treatment with renin angiotensin system (RAS) blockers was associated with less risk for progression.Conclusion.Dialysis is not inevitable in LN-related advanced CKD because 62% of our patients did not progress over 10 years of followup on average. Certain predictors were identified to affect progression to ESRD.
The Renal Resistive Index: A New Biomarker for the Follow-up of Vascular Modifications in Systemic Sclerosis
Authors: Gigante Antonietta , Bruni Cosimo , Lepri Gemma , Tesei Giulia , Maestripieri Vanessa , Guiducci Serena , Moggi-Pignone Alberto , Melchiorre Daniela , Boddi Maria , Bellando-Randone Silvia , Rosato Edoardo , Matucci-Cerinic Marco 
Published: April 2020

Objective.The aim of the present retrospective observational study was to evaluate the change of Renal Resistive Index (RRI) over time (ΔRRI) and under treatment in patients with systemic sclerosis (SSc) as well as to correlate these changes with disease complications.Methods.Two hundred thirty patients [29 male, median age 57 (IQR 48–67) yrs] were enrolled. At baseline and follow-up (3.43, IQR 2.81–4.45 yrs), we collected the following data: disease variables, nailfold videocapillaroscopy (NVC) pattern, forced vital capacity (FVC), diffusing lung capacity for carbon monoxide (DLCO), systolic pulmonary arterial pressure (sPAP), presence of interstitial lung disease, RRI, evaluation of glomerular filtration rate, and new onset of pulmonary arterial hypertension (PAH).Results.RRI value is high in SSc patients with digital ulcers and anticentromere antibodies, active and late NVC patterns, and limited cutaneous SSc. A significant correlation was observed between ΔRRI and ΔsPAP (R = 0.17, P = 0.02), with statistically higher ΔRRI (0.08 ± 0.02 vs 0.03 ± 0.05, P = 0.04) in patients complicated by PAH onset. No other new-onset complication was associated with ΔRRI. The receiver-operating characteristic curve analysis confirmed the predictive role of ΔRRI in development of new PAH (area under the curve 0.84, 95% CI 0.75–0.93, P = 0.02). In patients with SSc never exposed to sildenafil, ΔRRI was higher (0.04 ± 0.05) compared to both patients exposed to sildenafil during the study period (0.01 ± 0.05, P = 0.03) or in those exposed at the time of baseline evaluation (0.00 ± 0.05, P = 0.01).Conclusion.RRI and its variation in time are a reliable marker of SSc-related vasculopathy, both in renal and extrarenal compartments.
Secretome-Mediated Interactions with Intestinal Epithelial Cells: A Role for Secretome Components from Lactobacillus rhamnosus R0011 in the Attenuation of Salmonella enterica Serovar Typhimurium Secretome and TNF-α–Induced Proinflammatory Responses
Authors: Jeffrey Michael P. , MacPherson Chad W. , Mathieu Olivier , Tompkins Thomas A. , Green-Johnson Julia M. 
Published: April 2020

Abstract
Recent evidence suggests that lactic acid bacteria communicate with host cells via secretome components to influence immune responses but less is known about gut-pathogen secretomes, impact of lactic acid bacteria secretomes on host–pathogen interactions, and the mechanisms underlying these interactions. Genome-wide microarrays and cytokine profiling were used to interrogate the impact of the Lactobacillus rhamnosus R0011 secretome (LrS) on TNF-α and Salmonella enterica subsp. enterica serovar Typhimurium secretome (STS)–induced outcomes in human intestinal epithelial cells. The LrS attenuated both TNF-α– and STS-induced gene expression involved in NF-κB and MAPK activation, as well as expression of genes involved in other immune-related signaling pathways. Specifically, the LrS induced the expression of dual specificity phosphatase 1 (DUSP1), activating transcription factor 3 (ATF3), and tribbles pseudokinase 3 (TRIB3), negative regulators of innate immune signaling, in HT-29 intestinal epithelial cells challenged with TNF-α or STS. TNF-α– and STS-induced acetylation of H3 and H4 histones was attenuated by the LrS, as was the production of TNF-α– and STS-induced proinflammatory cytokines and chemokines. Interestingly, the LrS induced production of macrophage migration inhibitory factor (MIF), a cytokine involved in host–microbe interactions at the gut interface. We propose that the LrS attenuates proinflammatory mediator expression through increased transcription of negative regulators of innate immune activity and changes in global H3 and H4 histone acetylation. To our knowledge, these findings provide novel insights into the complex multifaceted mechanisms of action behind secretome-mediated interdomain communication at the gut-mucosal interface.
Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury
Authors: Skopelja-Gardner Sladjana , Colonna Lucrezia , Hermanson Payton , Sun Xizhang , Tanaka Lena , Tai Joyce , Nguyen Yenly , Snyder Jessica M. , Alpers Charles E. , Hudkins Kelly L. , Salant David J. , Peng YuFeng , Elkon Keith B. 
Published: April 2020

Abstract
Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic nature of human lupus by embodying three key genetic alterations: the Sle1 interval leading to anti-chromatin autoantibodies; Mfge8−/−, leading to defective clearance of apoptotic cells; and either C1q−/− or C3−/−, leading to low complement levels. We report that proliferative glomerulonephritis arose only in the presence of all three abnormalities (i.e., in Sle1.Mfge8−/−C1q−/− and Sle1.Mfge8−/−C3−/− triple-mutant [TM] strains [C1q−/−TM and C3−/−TM, respectively]), with structural kidney changes resembling those in LN patients. Unexpectedly, both TM strains had significant increases in autoantibody titers, Ag spread, and IgG deposition in the kidneys. Despite the early complement component deficiencies, we observed assembly of the pathogenic terminal complement membrane attack complex in both TM strains. In C1q−/−TM mice, colocalization of MASP-2 and C3 in both the glomeruli and tubules indicated that the lectin pathway likely contributed to complement activation and tissue injury in this strain. Interestingly, enhanced thrombin activation in C3−/−TM mice and reduction of kidney injury following attenuation of thrombin generation by argatroban in a serum-transfer nephrotoxic model identified thrombin as a surrogate pathway for complement activation in C3-deficient mice. These novel mouse models of human lupus inform the requirements for nephritis and provide targets for intervention.
Vertical characteristics of aerosol hygroscopicity and impacts on optical properties over the North China Plain during winter
Authors: Liu Quan , Liu Dantong , Gao Qian , Tian Ping , Wang Fei , Zhao Delong , Bi Kai , Wu Yangzhou , Ding Shuo , Hu Kang , Zhang Jiale , Ding Deping , Zhao Chunsheng 
Published: April 2020

Abstract. The water uptake of aerosol influences its optical depth and capacity for
cloud formation, depending on the vertical profile of aerosol hygroscopicity
because of different solar radiation received and supersaturation (SS) conditions
at different atmospheric levels. Such information is lacking over the polluted
East Asian region. This study presents aircraft-based in situ measured aerosol
size distributions and chemical compositions by a series of flights over
the Beijing area in wintertime. Under high relative humidity (hRH) conditions (surface
RH > 60 %), a significant enhancement of aerosol
hygroscopicity parameter (κ) in the planetary boundary layer (PBL)
was observed to increase by 50 % from 0.20 up to 0.34 from the surface to
the top of the PBL (vertical gradient of ∼0.13 km−1), along
with the dry particle effective diameter (Deff) being increased by
71 % and activation ratio up to 0.23 (0.64) at SS =0.05 % (0.1 %).
However, a lower vertical gradient of κ (0.05 km−1) and smaller
Deff was exhibited under low RH (lRH, surface RH < 60 %). This
suggests that the aqueous processes played an important role in promoting the
enhancement of particle hygroscopicity in the PBL. The κ in the
lower free troposphere (LFT) was relatively stable at 0.24±0.03 with
a slight increase during regional transport. The enhancement of aerosol
optical depth (AOD) due to water uptake ranged 1.0–1.22 for the PBL under lRH
and LFT, but it reached as high as 6.4 in the PBL under hRH. About 80 % and
18 % of the AOD were contributed to by aerosol hygroscopic growth under hRH
and lRH, respectively. These results emphasize the important evolution of
aerosol water-uptake capacity in the PBL, especially under the high RH
condition.
Development of a new nanoparticle sizer equipped with a 12-channel multi-port differential mobility analyzer and multi-condensation particle counters
Authors: Lee Hong Ku , Lee Handol , Ahn Kang-Ho 
Published: April 2020

Abstract. Measuring particle size distributions precisely is an important concern in addressing environmental and human health-related issues. To measure
particle size distributions, a scanning mobility particle sizer (SMPS) is often used. However, it is difficult to analyze particle size
distributions under fast-changing concentration conditions because the SMPS cannot respond fast enough to reflect current conditions due to the
time necessary for voltage scanning. In this research, we developed a new nanoparticle sizer (NPS), which consists of a multi-port differential
mobility analyzer (MP-DMA) with 12 sampling ports and multi-condensation particle counters (M-CPCs) that simultaneously measure concentrations of
particles classified by the sampling ports. The M-CPC can completely condense particles larger than 10 nm, and the total particle concentrations
measured by each CPC in the M-CPCs and an electrometer were in agreement up to 20 000 no.cm-3. We conducted size
distribution measurements under steady-state conditions using an aerosol generator and under unsteady conditions by switching the aerosol supply
on or off. The data obtained by the NPS corresponded closely to the SMPS measurement data for the steady-state particle concentration case. In
addition, the NPS could successfully capture the changes in particle size distribution under fast-changing particle concentration
conditions. Finally, we present NPS measurement results of size distributions in a common situation (cooking) as an exemplary real-world application.