bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and verification of a model for predicting fall risk in patients with maintenance hemodialysis†
Authors: Liu Yue , Zeng Yan-Li , Zhang Shan , Meng Li , He Xiao-Hua , Tang Qing 
Published: December 2024

Abstract

Objective
To construct a risk prediction model for fall in patients with maintenance hemodialysis (MHD) and to verify the prediction effect of the model.

Methods
From June 2020 to December 2020, 307 patients who underwent MHD in a tertiary hospital in Chengdu were divided into a fall group (32 cases) and a non-fall group (275 cases). Logistic regression analysis model was used to establish the influencing factors of the subjects. Hosmer–Lemeshow and receiver operating characteristic (ROC) curve were used to test the goodness of fit and predictive effect of the model, and 104 patients were again included in the application research of the model.

Results
The risk factors for fall were history of falls in the past year (OR = 3.951), dialysis-related hypotension (OR = 6.949), time up and go (TUG) test (OR = 4.630), serum albumin (OR = 0.661), frailty (OR = 7.770), and fasting blood glucose (OR = 1.141). Hosmer–Lemeshow test was P = 0.475; the area under the ROC curve was 0.907; the Youden index was 0.642; the sensitivity was 0.843; and the specificity was 0.799.

Conclusions
The risk prediction model constructed in this study has a good effect and can provide references for clinical screening of fall risks in patients with MHD.
Nonspecialists providing perinatal depression services in China: a qualitative study†
Authors: Zhu Yuan , Xuan Zhi-Yi , Xu Min , Tang Xiao-Mei , Li Qian , Xu Gui-Hua 
Published: December 2024

Abstract

Objective
To involve stakeholders in Jiangsu Province, China, to identify barriers for nonspecialist-delivered perinatal depression (PND) management to guide management in maternity and child health care institutions.

Methods
In this qualitative study, semi-structured face-to-face individual interviews were used, guided by the Consolidated Framework for Implementation Research (CFIR). Thematic analysis was done to categorize data using the CFIR framework’s domains.

Results
There were a total of 20 interviewees. Barriers coded under the CFIR framework included: needs and resources of those served by the organization, cosmopolitanism, available resources, structural characteristics, access to knowledge and information, and knowledge and beliefs.

Conclusions
Implementing nonspecialist-delivered PND management poses varying obstacles in different situations. Overcoming these barriers can be accomplished by simplifying interventions based on local conditions, changing women’s and families’ attitudes and help-seeking behaviors toward PND, establishing linkages with psychiatry, strengthening policymakers’ capacity and improving mental health care systems, developing detailed intervention manuals, enhancing clinicians’ mental health literacy, and improving the operation of psychologically appropriate approaches to build self-efficacy.
Enablers and barriers of implementing shared governance in nursing departments: a case study from the United Arab Emirates
Authors: Kurup Siboj , Manalastas Anne Paula , Ciruelas Jayzafer 
Published: December 2024

Abstract

Objective
The literature provides evidence about the positive impact of shared governance implementation in nursing departments and units, as well as on several aspects of nursing practice, including nurse empowerment, engagement, well-being, job satisfaction, retention, and positive outcomes in direct patient care. Accordingly, many nursing departments of United Arab Emirates (UAE) hospitals have implemented shared governance in their units. However, the success of implementation varies among these hospitals. Therefore, the study aimed to explore the progress of shared governance implementation in hospitals, identify the enablers and inhibitors of implementing the model, and produce a recommendation to help the nursing departments of hospitals to overcome challenges and accelerate the implementation process.

Methods
The study used an inductive, qualitative case-study research method and semi-structured in-depth interviews with a purposive sample of 15 nurses working in various units in a tertiary hospital in UAE. The authors used a thematic data analysis approach to find the results.

Results
The results identified immediate manager understanding and support as a significant enabler and lack of senior management support, nurses’ attitudes and behaviors, and time as the main barriers. The study highlights that nurses are positive and enthusiastic about improving the current situation of shared governance by providing several suggestions and strategies.

Conclusions
The study highlights that senior nursing managers should re-evaluate shared governance implementation and modify the strategies accordingly.
Effect of peer education on knowledge, attitude, and practice of HPV infection prevention among college students
Authors: Zhang Rong-Rong , Xu Yan 
Published: December 2024

Abstract

Objective
To explore the effect of peer education on improving the knowledge, attitude, practice level (KAP) to prevent human papilloma virus (HPV) infection among college students.

Methods
The knowledge, attitude/belief, and practice level of 536 grade I college students from a university in Shanghai were surveyed and analyzed using a self-designed questionnaire—the HPV Infection and Prevention KAP Questionnaire.

Results
Many college students heard about HPV vaccine (49.70% before peer education and 100% after peer education); however, few of them were vaccinated (2.82% before peer education and 5.23% after peer education). Knowledge, attitude/belied, and practice of HPV infection prevention were positively related (P < 0.05). Peer education was effective in improving college students’ KAP level of HPV infection prevention (P < 0.05).

Conclusions
Peer education could be used as a strategy in colleges to improve student’s KAP level of HPV infection prevention. College students may also be encouraged to spread their influence to society.
Relationship of sociodemographic factors and low birth weight in toddlers
Authors: Rohmah Nikmatur , Wulandari Indah , Firdaus Agil Khoironi , Auliya Nabilah , Imanda Novannisa , Anggraini Dwi Ningtyas 
Published: December 2024

Abstract

Objective
This study analyzes the relationship between sociodemographic factors and low birth weight (LBW) in toddlers.

Methods
The research design uses a correlational method. The population is 303 mothers with toddlers aged 12–60 months in Lojejer Wuluhan Jember Village, East Java, Indonesia. The cluster sampling took 172 samples in total. The sociodemographic variables measured included the father’s and the mother’s age, the father’s and mother’s education, family income, the father’s occupation, the mother’s occupation, and the child’s gender. Data collection techniques used questionnaires and document studies in the Maternal Child Health (MCH) handbook. Data were analyzed using logistic regression.

Results
The results showed that the variable age of the father and mother ≥20 years was a protective factor for the incidence of LBW. Family income <IDR 3,000,000 per month, fathers with farm workers and fishermen as occupation, male sex, and low father’s education were predictor factors for LBW.

Conclusions
This study concluded that the variable sociodemographic factors related to LBW in toddlers in Lojejer Wuluhan Village, Jember district, East Java Province, Indonesia. Therefore, the government needs to establish stricter policies in terms of maturing the age of marriage to reduce the incidence of LBW.
Bioweathering of Egyptian Nubian sandstone and Theban limestone: three months insight by experimental incubation
Authors: Potysz Anna , Osman Amr , Bartz Wojciech 
Published: December 2024

Abstract
This study undertook laboratory incubation approach to examine abiotic and biotic factors potentially influencing the bioweathering of Egyptian dimension stones, namely Nubian sandstone and Theban limestone. The dynamic and efficiency of metal release were assessed by means of bioleaching experiments (quantification by inductively coupled plasma mass spectrometry), whereas potential element donor phases were identified by scanning electron microscopy (SEM-EDS). Overall, biotic weathering plays more of an important role for initiation of limestone dissolution, whereas its contribution to sandstone dissolution is more specific to host minerals accommodating individual elements. Kaolinite and Fe-bearing cement minerals (ilmenite and magnetite) in sandstones were found to be particularly attractive to bacteria that enhanced Al and Fe leaching by factors up to 7.0 and 5.7, respectively. Leaching of Al and Fe from limestone was enhanced by a factor up to 13 in the presence of bacteria. Siderophore concentration in biotic incubation reached 45.2-75.5 μmol L−1 and 90.6 μmol L−1 for sandstones and limestone, respectively. Regardless of immersed solid, higher Ca and Mg leaching from calcite and dolomite under chemical instead of biotic conditions was observed indicating either preferential mineral colonization by bacteria or surface passivation by biofilm. At the end of chemical incubation, up to 34.1% of Ca and up to 27.0% of Mg were leached from sandstones, whereas leaching observed for limestone was up to 0.6% (Ca) and 16.3% (Mg). Limestone dissolution was assessed at up to 1.2% (Si). This study has implications for understanding the dissolution of dimension stone used as construction and building materials and cultural heritage objects such as monuments and ornaments.
Loss of Chance in Labor Relations: a Civil Liability Perspective
Authors: Carneiro Evellyn Ferreira Cedraz , Feitosa Sofia Santos , Mariz Laíse , Coelho Isadora Moura Fé Cavalcanti 
Published: December 2024

Objective: This article aims to analyze the applicability of this theory in the context of labor relations.

Theoretical Framework: The loss of chance is a theory of civil liability understood as the deprivation of an opportunity to obtain an advantage or avoid a loss, resulting from the conduct of a third party. We used the theoretical foundations of Civil Law, based on authors such as Maria Helena Diniz, Gustavo Tepedino and Flávio Tartuce to verify the relevance of the applicability of the loss of chance based on actions or omissions, even if superficially considered lawful, but which reveal abuse of rights by the employer.

Method: The research follows the monographic procedure, with application of the deductive method and, in relation to the results, is classified as qualitative. According to the objectives, this research is classified as exploratory, aiming at the deepening of the content, based on a bibliographic survey on the subject, using books, magazines, newspapers and legislation.

Results and Discussion: We conclude that the theory of loss of chance is particularly relevant in the labor field, considering the opportunities for professional advancement and economic benefits that may be affected. We analyzed decisions of the Regional Labor Courts to establish the criteria for configuring the loss of chance and quantifying compensation.

Research Implications: We believe that this research can help identify situations of abuse of rights by the employer and the applicability of the thesis studied here, in addition to serving as a parameter for the Judiciary, without prejudice to the discretion in relation to each case, in view of a fairer and more individualized assessment of damages, taking into account the specific context of each worker and the circumstances surrounding the lost opportunity.

Originality/Value: This study contributes to the literature on the theory of loss of opportunity, which is vast in the civil field, but still little explored in Labor Law. The research can help establish the criteria for configuring the loss of chance and quantifying compensation.
Potential of Nisin and Newly Discovered Bacteriocins as Preservatives for Pasteurised Milk
Authors: Okiko Getrude , Sugrue Ivan , Ogutu Fredrick O. , Ross Paul 
Published: December 2024

Spoilage of pasteurized milk is mainly caused by the presence of organisms that either survive pasteurization (psychrotolerant spore-formers) or re-contaminate milk in the processing environment (post-pasteurisation contaminants). Pasteurization of bovine milk by heat treating at 72°C for 15-30 seconds ensures milk quality without impairing its organoleptic and nutritional status and extends shelf life to 12-14 days at refrigeration temperatures. Nisin A is a class I bacteriocin known to inhibit gram positive bacteria and approved by the European Food and Safety Authority as a food preservative. It is commercially available as Nisaplin®, which contains a concentration of 2.5% w/w of nisin. This study examined the effect of Nisaplin® at different concentrations on spoilage of refrigerated commercial whole pasteurized milk over a period of 59 days. At a high concentration of 4 mgml-1, Nisaplin® reduced the total bacterial count below the limit of detection in the milk, and inhibition was visible for at least 14 days at 4°C. Previously isolated milk spoilage bacteria were identified using 16s rRNA gene sequencing and utilised as target indicators for bacteriocin production. Lactobacillus delbrueckii ssp. bulgaricus LMG6901, Microbacterium lacticum, and Pseudomonas aeruginosa were utilised as indicator strains in a screen of milk spoilage organisms for bacteriocin production. This resulted in identifying the putative bacteriocin producer Carnobacterium divergens, a lactic acid bacterium active against L. bulgaricus. The study concludes that Nisaplin® is effective in the reduction of microbial load and its effectiveness could be increased when combined with other preservative methods thus forming an extra hurdle in the milk.
Domates ve Hıyar Örneklerinde Element İçeriğinin ve Pestisit Kalıntılarının Araştırılması: Tekirdağ (Türkiye) ve Mamuşa (Kosova) Örneği
Authors: Duraklı Velioğlu Serap , Güner Kadir Gürbüz , Sahiti Mehmeti Zana , Sağlam Özgür , Velioğlu Hasan Murat 
Published: December 2024

Bu çalışmanın amacı, Mamuşa (Kosova) ve Tekirdağ’da yetiştirilen domates ve hıyarlarda yaygın olarak kullanılan bazı pestisitlerin kalıntılarının ve bazı toksik metallerin varlığının araştırılmasıdır. Çalışma kapsamında Tekirdağ ve Mamuşa’dan toplanan 21 domates ve 17 hıyar numunesinde pestisit kalıntı ve element analizleri gerçekleştirilmiştir. Pestisit etken maddeleri olarak abamectin, acetamiprid, carbendazim, chlorpyrifos methyl, imidacloprid, metaflumizone, propineb ve indoxacarb seçilmiştir. Elemental analizde ise bazı toksik metaller dahil 26 elementin taraması yapılmıştır. İncelenen örneklerin hiçbirisinde maksimum kalıntı limiti (MRL) üzerinde pestisit kalıntısı saptanmamıştır. Acetamiprid domateste 16 örnekte (0,25-267 µg kg-1), hıyarda 10 örnekte (0,30-202 µg kg-1), imidacloprid sadece domateste 5 örnekte (4,38-8,83 µg kg-1), indoxocarb domateste bir örnekte (21,80 µg kg-1), propineb Mamuşa’dan toplanan tüm hıyar örneklerinde (187-1090 µg kg-1) tespit edilmiştir. Elemental analiz sonuçları incelendiğinde kalay domateste 9 örnekte (10,3-12,8 mg kg-1), hıyarda 2 örnekte (10,9-13,4 mg kg-1), nikel sadece Tekirdağ’dan toplanan birer domates (14,7 mg kg-1) ve hıyar (11,3 mg kg-1) örneğinde tespit edilmiştir. Alüminyum ise analizi yapılan 3 hıyar örneğinde (10,0-36,1 mg.kg-1) tespit edilmiştir. Örneklerin hiçbirinde kurşun, kadmiyum ve civaya rastlanmaması olumlu bir durumdur. İncelenen örneklerde tespit edilen kalıntıların insan sağlığı için risk oluşturacak düzeyde olmadığı ifade edilebilir. Ancak tarımsal üretimde kullanılan su, gübre ve pestisitlerin son üründe kalıntı bırakma potansiyeline sahip olduğunu gösteren örnekler olması, üreticileri iyi tarım uygulamalarını sürdürmeye teşvik etmelidir.
Public opinion on Indonesia's capital relocation policy: a netnographic analysis
Authors: Priyowidodo Gatut , Angela Wijayanti Chory 
Published: December 2024

The pros and cons of relocating the National Capital City have remained an unresolved issue across different regimes. When President Joko Widodo took concrete action to relocate IKN legally, the DPR approved through Law (UU) Number 3 of 2022 concerning the National Capital City (IKN), which was passed on January 18, 2022; the public immediately responded with acceptance and rejection. The dynamics of public conversations and comments through social media are intense. This research aims to answer public responses regarding the new relationship between the centre and the areas after passing the IKN Law. Using the netnography method, data were downloaded from the comment section of eight (8) YouTube accounts– CNBC Channel, detik.com, Narasi, TV One, Metro, RH Channel, RG Channel, and ILC Channel. This study employed thematic analysis and data processing with NVIVO 14 application. The research findings show that the eight YouTube accounts with more than 25,000 comments were categorised into two major themes. The first is an optimistic theme that expresses approval for the relocation of IKN. The reason is to improve welfare (Java-outside Java), long-term development planning, pro to the people, and show strong leadership to bridge the centre and regions. The two pessimistic themes expressed rejection, citing concerns about natural damage, potential corruption due to limited government finances, social inequality, and not being pro-people. This research recommends that the IKN relocation policy be understood optimistically and holistically, especially in central-regional relations and equitable distribution of economic access for a more prosperous Indonesia.
Unlocking the antiviral arsenal: Computational exploration of Langya virus (L, C, V, W) through phylogenetic analysis and molecular modeling
Authors: Paritala Venu , Kalva Sukesh , Shagamreddy Rajashekhar Reddy 
Published: December 2024

Objectives:
In response to the ongoing COVID-19 pandemic and the resurgence of the Langya virus (LayV) in Eastern China, there is an urgent need for novel antiviral treatments. Given the limited research available on LayV, this study aimed to explore its evolutionary relationships and construct accurate three-dimensional (3D) models of key viral proteins, which are essential for understanding the virus’s mechanisms and vulnerabilities.

Materials and Methods:
Computational approaches were employed to examine the evolutionary relationships of LayV using Molecular Evolutionary Genetics Analysis (MEGA). To build reliable 3D protein structures of the viral proteins C, L, W, and V, SwissModel and Faster AlphaFold (AF) were utilised. Model validation was conducted in PROCHECK, PROSA, Errat, Verify 3D, and Prove. Additionally, binding site analysis was carried out using various platforms such as Computed Atlas of Surface Topography of Proteins (CASTp), PHYRE2, PrankWeb, and SCFBio to ensure the robust identification of key interaction sites.

Results:
The phylogenetic analysis revealed that LayV is closely related to the Henipavirus genus. The structural models generated through SwissModel for the C, L, and W proteins showed high accuracy, with 93.2%, 89.4%, and 87.5% of residues residing in favoured regions, respectively. The AF model of the V protein exhibited optimal structural validation, with 82.0% of residues in favoured regions. Binding site analysis identified key interaction regions essential for targeted drug design.

Conclusion:
This comprehensive study highlighted the close evolutionary relationship between LayV and Henipaviruses and validated the structural models of key LayV proteins, offering a foundation for future antiviral drug design. The robust computational analysis and structural modelling provide a critical framework for selective drug development, contributing to the strategic fight against LayV.
Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm
Authors: Yong Jun , Tang Shanshan , Yu Lin , Li Meng , Zhang Fang , Fan Xiujie 
Published: December 2024

Objective:
Abdominal aortic aneurysm (AAA) is a complex and fatal vascular disease for which specific treatments are still lacking. This study explored the effect and possible mechanisms of prenyl diphosphate synthase subunit 2 (PDSS2) on angiotensin II (Ang II)-induced AAA in human vascular smooth muscle cells (VSMCs).

Material and Methods:
The AAA cell model was established by treating VSMCs with 1 μM Ang II for 24 h. The effect of Ang II on VSMC viability was detected by cell counting kit-8 assay. The role of PDSS2 on VSMC proliferation was examined using the 5-ethynyl-2'-deoxyuridine method. The influence of Ang II and PDSS2 on VSMC apoptosis was analyzed by flow cytometry. The expression changes of PDSS2, apoptosis-related proteins, and phosphatidylinositol 3 kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) pathway-related proteins were detected by Western blot analysis.

Results:
After treatment with Ang II, the VSMCs showed decreased viability and increased apoptosis (P < 0.01). PDSS2 expression was low in the AAA tissues and Ang II-treated VSMCs (P < 0.01). PDSS2 promoted the proliferation and blocked the apoptosis of Ang II-treated VSMCs, and si-PDSS2 showed the opposite effect (P < 0.01). PDSS2 also decreased the levels of p-mTOR, p-AKT, and p-PI3K, which, in turn, were increased by si-PDSS2 (P < 0.01).

Conclusion:
PDSS2 was downregulated in AAA and retarded the progression of VSMCs partially through the PI3K/AKT/mTOR pathway. This work explored the molecular mechanism of PDSS2 in the prevention, diagnosis, and treatment of AAA.
Evaluation of simplified carbapenem inactivation method (sCIM) as a phenotypic method for rapid detection of carbapenemase-producing Enterobacterales: Study from a tertiary care hospital in North India
Authors: Archana Archana , Kokkayil Prathyusha , DebBarma Pramurtajyoti , Priyadarshi Ketan , Thakuria Bhaskar 
Published: December 2024

Objectives:
This study aims to assess the feasibility of using the simplified carbapenem inactivation method (sCIM) for detecting carbapenemase production, specifically comparing its efficacy with the modified carbapenem inactivation method (mCIM), emphasizing methods applicable in low-resource settings and a minimal learning curve.

Materials and Methods:
To evaluate the performance of sCIM, 102 clinical isolates of carbapenem-resistant Enterobacterales (CREs) (detected by Kirby–Bauer disk diffusion technique) were selected, which had previously undergone both mCIM testing and genotyping detection of common carbapenemase-encoding genes. Polymerase chain reaction analysis of the isolates was done with specific primers targeting carbapenemase genes (blaNDM, blaIMP, blaVIM, blaSPM, blaKPC, and blaOXA48).

Statistical analysis:
Data were analyzed using the Statistical Package for the Social Sciences v.23. Quantitative variables were described using mean ± standard deviation or median (interquartile range). Categorical variables were described using proportions.

Results:
The sensitivity of sCIM was 90.43%, with a specificity of 87.5% when compared to the mCIM. The organism-wise analysis revealed notable sensitivity rates for Escherichia coli (93.44%) and Klebsiella pneumoniae (84.38%). Highlighting the efficacy of sCIM in identifying carbapenemase production in them. The specificity for sCIM remained high across all species, with 100% specificity for E. coli and 80% specificity for K. pneumoniae.

Conclusions:
The findings of our study support the efficacy of sCIM as a sensitive and specific method for the rapid detection of carbapenemase-producing CRE. The simplification of procedures and improved detection capabilities make sCIM a promising tool for timely and accurate identification, offering advantages over the traditional mCIM.