bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine
Authors: Hasheminasab Fatemeh Sadat , Sharififar Fariba , Hashemi Seyed Mehdi , Setayesh Mohammad 
Published: February 2020

Background:Cancer is one of the most prevalent diseases associated with heavy complications in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences, mucositis also affects patients' quality of life. In Traditional Persian Medicine (TPM) manuscripts, several medicaments have been suggested for the treatment of mucositis.Objective:Considering the public welcome for herbal medicine, the current evidence-based review study is conducted to investigate the herbal remedies which have been proposed for oral mucositis in TPM.Methods:At first, a comprehensive survey was done on Qanon fi al-Teb, which is the most important textbook of TPM; then the scientific name of the herbs was authenticated according to the botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science direct were investigated for possible relevant properties of each medicinal plant in the literature.Results:In total, 30 herbs are introduced in this study. According to the registered documents, 18 herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated against oral mucositis on the literature.Conclusion:Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments.
Chemical Analysis, Phenolic Content, and Antioxidant Activities of Aqueous and Organic Moroccan Juglans regia L. Bark Extracts
Authors: Boulfia Mohamed , Lamchouri Fatima , Toufik Hamid 
Published: February 2020

Background:The present study was conducted on the Moroccan Juglans regia L. bark, in comparison with other Juglans regia collected in other countries, to study the effects of the use of different extraction solvents (water, ethanol, acetone, and diethyl ether), aqueous and organic extraction method, hot and cold extraction by maceration modalities on the presence and content of the different phytochemicals, and on the antioxidant activity.Methods:Various solvents of increasing polarity were used for the preparation of aqueous and organic extracts. Afterwards, a phytochemical screening, an estimation of phenolic compounds, flavonoids, and tannins contents was conducted. The in vitro antioxidant activity was carried out by five tests: H2O2, ABTS, FRAP, DPPH, and reducing power. Subsequently, Principal Component Analysis (PCA) was used to establish the correlation between phenol content and antioxidant activity.Results:Phytochemical analysis showed that the 9 extracts prepared are characterized by the presence of flavonoids, catechic tannins, saponins, anthraquinones, and quinones, and that the macerated acetone extract contains the highest content of phenolic compounds (327.972±0.06 μgEAG/mgE), flavonoids (1267.981±2.911 μgEQ/mgE), and tannins (38.056±1.886 μgEC/gE). The best antioxidant activity was obtained with the macerated acetone which was found to be the most active via the five different tests, with a percentage of scavenging of H2O2 equal at 24.13±1.81, a higher value of ABTS equal to 602.29±0.34 μgET/mgE. PCA allowed us to deduce that phenolic compounds, flavonoids, and tannins are strongly correlated with antioxidant activity.Conclusion:Moroccan Juglans regia may be one of the potential sources of antioxidant compounds.
Predicting Thermophilic Proteins by Machine Learning
Authors: Wang Xian-Fang , Gao Peng , Liu Yi-Feng , Li Hong-Fei , Lu Fan 
Published: February 2020

Background:
Thermophilic proteins can maintain good activity under high temperature,
therefore, it is important to study thermophilic proteins for the thermal stability of proteins.

Objective:
In order to solve the problem of low precision and low efficiency in predicting
thermophilic proteins, a prediction method based on feature fusion and machine learning was
proposed in this paper.

Methods:
For the selected thermophilic data sets, firstly, the thermophilic protein sequence was
characterized based on feature fusion by the combination of g-gap dipeptide, entropy density and
autocorrelation coefficient. Then, Kernel Principal Component Analysis (KPCA) was used to reduce
the dimension of the expressed protein sequence features in order to reduce the training time and
improve efficiency. Finally, the classification model was designed by using the classification
algorithm.

Results:
A variety of classification algorithms was used to train and test on the selected thermophilic
dataset. By comparison, the accuracy of the Support Vector Machine (SVM) under the jackknife
method was over 92%. The combination of other evaluation indicators also proved that the SVM
performance was the best.

Conclusion:
Because of choosing an effectively feature representation method and a robust
classifier, the proposed method is suitable for predicting thermophilic proteins and is superior to
most reported methods.
Omalizumab in the Treatment of Chronic Urticaria: The Effect of Drug Co-Administration and Co-Morbidities
Authors: Tagka Anna , Lambrou George I. , Nicolaidou Electra , Nakou Evangelia , Makris Michael , Stratigos Alexandros , Katsarou Alexandra 
Published: February 2020

Background:Chronic Spontaneous Urticaria (CSU) is a disease presenting typical wheals characterized by itching, angioedema or both. Although CU is, by appearance, a relatively “simple” disease, yet it has a devastating effect on those suffering due to its immense social implications.Aims:The aim of the present study was to investigate the effect of omalizumab in the treatment of CSU. In particular, gender, co-administration of drugs and comorbidities were taken into account.Materials and Method:108 patients (25 Males/83 Females) admitted to our department were diagnosed with CSU and were treated for 30 months. CSU was estimated on a score basis, which was used in order to define disease severity. The mean total CSU score and the mean CSU score of the first trimester, as well as the first semester, were calculated. Patients were treated with omalizumab, and in several cases, with co-administration of dapsone, cyclosporine and anti-histamines.Results:Females manifested significantly higher scores as compared to males. Further on, patients who relapsed manifested significantly higher scores during the whole time course, as well as at the end of the first semester.Conclusions:Females are more prone to CSU. Although CSU scores in patients with remission, relapse and poor response manifested no significant difference at diagnosis, relapsed patients manifested higher CSU scores in the first semester. Therefore, the first semester of treatment is probably critical for the final patient outcome. Further studies are necessary in order to understand the mechanisms of CSU for better treatment and prognosis.
Next-Generation Sequencing–Based Cancer Panel Data Conversion Using International Standards to Implement a Clinical Next-Generation Sequencing Research System: Single-Institution Study
Authors: Park Phillip , Shin Soo-Yong , Park Seog Yun , Yun Jeonghee , Shin Chulmin , Jung Jipmin , Choi Kui Son , Cha Hyo Soung 
Published: February 2020

Background
The analytical capacity and speed of next-generation sequencing (NGS) technology have been improved. Many genetic variants associated with various diseases have been discovered using NGS. Therefore, applying NGS to clinical practice results in precision or personalized medicine. However, as clinical sequencing reports in electronic health records (EHRs) are not structured according to recommended standards, clinical decision support systems have not been fully utilized. In addition, integrating genomic data with clinical data for translational research remains a great challenge.

Objective
To apply international standards to clinical sequencing reports and to develop a clinical research information system to integrate standardized genomic data with clinical data.

Methods
We applied the recently published ISO/TS 20428 standard to 367 clinical sequencing reports generated by panel (91 genes) sequencing in EHRs and implemented a clinical NGS research system by extending the clinical data warehouse to integrate the necessary clinical data for each patient. We also developed a user interface with a clinical research portal and an NGS result viewer.

Results
A single clinical sequencing report with 28 items was restructured into four database tables and 49 entities. As a result, 367 patients’ clinical sequencing data were connected with clinical data in EHRs, such as diagnosis, surgery, and death information. This system can support the development of cohort or case-control datasets as well.

Conclusions
The standardized clinical sequencing data are not only for clinical practice and could be further applied to translational research.
Свободные прямоугольные n-кратные полугруппы
Authors: Жучок Анатолий Владимирович 
Published: February 2020

n-кратной полугруппой называется непустое множество G, снабженное n бинарными операциями $$\fbox{1}\,, \fbox{2}\,, ..., \fbox{n}\,,$$ удовлетворяющими аксиомам $$(x\fbox{r} \, y) \fbox{s}\, z=x\fbox{r}\,(y\fbox{s}\,z)$$ для всех $$x,y,z \in G$$ и $$r,s\in \{1,2,...,n\}.$$ Это понятие рассматривал Н.А.Корешков в контексте теории n-кратных алгебр ассоциативного типа. Доппельполугруппы являются 2-кратными полугруппами. n-кратные полугруппы имеют связи с интерассоциативными полугруппами, димоноидами, триоидами, доппельалгебрами, дуплексами, G-димоноидами и рестриктивными биполугруппами. Если операции n-кратной полугруппы совпадают, то она превращается в полугруппу. Таким образом, n-кратные полугруппы являются обобщением полугрупп. Класс всех n-кратных полугрупп образует многообразие. Недавно были построены свободная n-кратная полугруппа, свободная коммутативная n-кратная полугруппа, свободная k-нильпотентная n-кратная полугруппа и свободное произведение произвольных n-кратных полугрупп. Класс всех прямоугольных n-кратных полугрупп, то есть n-кратных полугрупп с n прямоугольными полугруппами, образует подмногообразие многообразия n-кратных полугрупп. В этой статье мы строим свободную прямоугольную n-кратную полугруппу и характеризуем наименьшую прямоугольную конгруэнцию на свободной n-кратной полугруппе.
RANCANG BANGUN SISTEM MONITORING RUANGAN LABORATORIUM RADIOGRAFI BERBASIS ARDUINO DAN ANDROID
Authors: Suhendro Budi , Witanto Pranowo Adi , Budianto Anwar 
Published: February 2020

Sistem monitoring menggunakan Internet Protocol Camera (IPcam) sebagai pemantau akhir-akhir ini semakin marak dipergunakan digedung-gedung perkantoran, universitas, pasar swalayan dan Automated Teller Machine (ATM) center. Closed Circuit TeleVision (CCTV) sendiri kini juga dipasang dan digunakan pada tempat-tempat yang memang memerlukan tingkat pengamanan cukup tinggi, seperti ruangan laboratorium radiografi yang menyimpan pesawat sinar-X. Pembuatan sistem monitoring ruangan laboratorium radiografi menggunanakan sensor ultrasonik untuk mendeteksi orang yang masuk ruangan. Setelah sensor ultrasonik dan servo aktif, Arduino menginterupsi wavecom untuk mengirimkan pesan ke telepon seluler operator radiografi. IPcam merekam kejadian diruangan dan video dapat diakses menggunakan Android oleh operator radiografi yang terkoneksi dengan jaringan internet. Sistem monitoring ruangan ini dapat mendeteksi orang ketika bergerak di suatu ruangan dengan jarak maksimal 3,5 m dari sensor ultrasonik.Kata kunci: Sensor ultrasonik, Arduino, Motor servo, IP kamera, SMS, Android.
Epigenetic Link Between Statin Therapy and Type 2 Diabetes
Authors: Ochoa-Rosales Carolina , Portilla-Fernandez Eliana , Nano Jana , Wilson Rory , Lehne Benjamin , Mishra Pashupati P. , Gao Xu , Ghanbari Mohsen , Rueda-Ochoa Oscar L. , Juvinao-Quintero Diana , Loh Marie , Zhang Weihua , Kooner Jaspal S. , Grabe Hans J. , Felix Stephan B. , Schöttker Ben , Zhang Yan , Gieger Christian , Müller-Nurasyid Martina , Heier Margit , Peters Annette , Lehtimäki Terho , Teumer Alexander , Brenner Hermann , Waldenberger Melanie , Ikram M. Arfan , van Meurs Joyce B.J. , Franco Oscar H. , Voortman Trudy , Chambers John , Stricker Bruno H. , Muka Taulant 
Published: February 2020

OBJECTIVE
To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood.

RESEARCH DESIGN AND METHODS
Five cohort studies’ participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated.

RESULTS
Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 × 10−25 [DHCR24]), cg10177197 (3.94 × 10−08 [DHCR24]), cg06500161 (2.67 × 10−23 [ABCG1]), cg27243685 (6.01 × 10−09 [ABCG1]), and cg05119988 (7.26 × 10−12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95% CI 1.22, 1.47]). Mediation analyses suggested that ABCG1 methylation partially mediates the effect of statins on high insulin and HOMA-IR. Gene expression analyses showed that statin exposure and ABCG1 methylation were associated with ABCG1 downregulation, suggesting epigenetic regulation of ABCG1 expression. Further, outcomes insulin and HOMA-IR were significantly associated with ABCG1 expression.

CONCLUSIONS
This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins’ effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to ABCG1 epigenetic regulation.
Ocorrência de febre maculosa brasileira no estado de minas gerais no período de 2013 a 2017
Authors: Lamas Luciano Gonçalves , Castro Jonathan Mendes de , Oliveira Talles Vinícius de Castro , Proti Enaile de Souza , Martins Ranyelli Estefany da Costa , Azevedo Marcela Alves , Araújo Diego Azevedo , Arruda Jacqueline Souza Dutra , Guerra Carlos Henrique Wernersbach , Costa Wendel Jose Teixeira 
Published: February 2020

Esse trabalho tem por objetivo descrever a ocorrência da Febre Maculosa Brasileira nas macrorregiões do estado de Minas Gerais no período de 2013 a 2017. Trata-se de estudo transversal, descritivo, com delineamento de série temporal e utilização de dados de natureza secundária referentes à ocorrência de casos de Febre Maculosa, da população residente no Estado de Minas Gerais. Observou-se maior incidência de casos de Febre Maculosa Brasileira em homens, com menos de 8 anos de estudos, idade entre 20 e 59 anos, raça parda e negra, residentes nas macrorregiões Jequitinhonha, Leste do Sul e Sudeste, com alta mortalidade no período analisado. Estes dados evidenciam necessidade de atenção do poder público nas áreas mais incidentes, com foco na Atenção Básica, a fim de modificar essa realidade através de campanhas de conscientização, abordando a identificação de sinais e sintomas da doença, medidas de controle de vetores e prevenção da contaminação, a fim de reduzir a ocorrência de casos e principalmente de óbitos.
Effect of dual task exercise to develop body balance, movement co-ordination and walking speed among post cervical injury clients
Authors: Dayanidhi Hota  , Sasmita Das  , Neethu Maria Joseph  
Published: February 2020

To determine the effect of level of body balance, movement coordination and walking speed among patients with a cervical injury. A true experimental design (pre-test and post-test control group) was set up in the physiotherapy unit of Regional Spinal Injury Centre (RSIC), Cuttack, Odisha. A total of 40 post cervical injury patients were selected who were undergoing single task exercises in the setting. Patients were divided randomly with 20 in experimental and 20 in the control group. The experimental group performed dual-task exercises (for hands and legs) for 6 days a week, continuing for 4 weeks. Body balance was measured using ‘berg balance scale’, movement coordination and walking speed assessed with ‘motor assessment scale’. There was a significant improvement in the scores of body balance and movement coordination among the experimental group. The control group showed no significant difference between the pre and post-test scores. There was no significant change in the pre and post-intervention scores of movement coordination and walking speed among the experimental and control group except in body balance. Dual-task exercises were helpful in developing the body balance, movement coordination and walking speed among post cervical injury patients.
Fighting on the Ocean Blue: New Zealand's Extra-Territorial Jurisdiction and Maritime Protest
Authors: Smith Timothy 
Published: February 2020

In this article the author discusses New Zealand's extraÂ­territorial jurisdiction over criminal acts which occur in the course of protest on the high seas. In particular, the jurisdictional provisions of the Crimes Act 1961 and the Maritime Crimes Act 1999 are analysed for consistency with international norms and for their value in deterring incidents of violence. The author concludes that, while imperfect, the current structure for asserting extraÂ­territorial jurisdiction is perhaps the most convenient given the uncertainty inherent in jurisdictional assertions.
KEBERADAAN HEWAN PENGOTOR TERITIP DI INFRASTRUKTUR TELUK KUNYIT, PANTAI SARIRINGGUNG DAN PANTAI MUTUN, LAMPUNG
Authors: Wijayanti Hendry , Herbowo Dhani Gathot , Darmawan Andy 
Published: February 2020

Abstrak: Teritip merupakan salah satu hewan pengotor yang umum hidup menempel pada infrastruktur buatan manusia yang teredam di dalam perairan laut. Fenomena penempelan teritip mengakibatkan kerusakan struktur bangunan pada infrastruktur di perairan laut. Tujuan penelitian ini menginventarisasi ÃÂ keberadaan jenis teritip yang menempel pada infrastruktur yang ada di area pantai yang berada di Teluk kunyit, Pantai Sariringgung dan Pantai Mutun sebagai langkah awal dalam pengendalian hewan pengotor. Penelitian dilakukan dengan metode survei selama bulan April and November 2018. Pada kedua Pantai Sariringgung dan Pantai Mutun ditemukan dua spesies teritip, Amphibalanus amphitrite dan Microeuraphia withersii. Namun, jenis teritip yang ditemukan di Teluk Kunyit hanya satu spesies Cthtamalus malayensis..Kata kunci: introduksi, biofouling, zona intertidal, Teluk Lampung.Abstract: Barnacle is the most common biofouling in the manmade ÃÂ submerged structures. Barnacles are a serious problem which leading the detriment of coastal structures. The aim of the study was to ÃÂ investigate the dataset of barnacale communities in Lampung shores, in order to monitor developing of biofouling. Three ÃÂ coastal areas of Teluk Kunyit, Sariringgung and Mutun were investigated between April and November 2018. It was found that two species, Amphibalanus amphitrite and Microeuraphia withersii, are found in both costal areas. In contrast, only colonial species of Cthtamalus malayensis has been found abundance in Teluk kunyit area.Keywords: introduction, biofouling, intertidal zone, Lampung Bay
Outcome of Endoscopic third Ventriculostomy for Obstructive Hydrocephalus due to Posterior Fossa Lesions
Authors: Sapkota Suresh , Shrestha Shikher , Bishokarma Suresh , Thulung Suraj , Kalu Bibhusan , Gongal Dinesh Nath 
Published: February 2020

Background and purpose: Obstructive hydrocephalus can be treated with External ventricular Drainage (ETV), Ventriculo peritoneal shunt insertion, upfront tumor removal without cerebrospinal fluid diversion procedures or more recently ETV. Aim of our study was to study the outcome of ETV in treating such patients.
Material and method: Descriptive observational study conducted at Upendra Devkota Memorial Institute Of Neurological and Allied Sciences from Sep 2015 to may 2017.
Result: Twenty-three patients met the inclusion criteria. Among which, 14 (39%) patients were male with male to female ratio of 1.55. We included wide age range from 3 years to 68 years. Seven patients (30.4%) were less than 10 years while 6 patients (23%) were above 60 years old. Patients with Posterior fossa presented with varied symptoms. Ten patients (43.4%) presented with decreased level of consciousness, 14 (60.8%) presented with visual symptoms, 17 (73.9%) presented with vomiting and 23 (100%) presented with headache (Figure. 3). Visual acuity was normal among 3 (13%), decreased among 11 (48%) and with no perception of light among 3 (13%). However, acuity was not assessed among 6 (26%) patients (Figure 4).Funduscopic evaluation revealed papilledema among 20 (87%) patients while secondary optic atrophy among 3 (13%) patients. Patients were evaluated in follow up for symptomatic improvement. Consciousness were improved among 8 (80%) patients, visual symptoms improved among 10 (71.4%) patients, vomiting subsided among 15 (88.2%) patients while headache improved among 100%. Following ETV, 5 (21.7%) patients developed complications, 3 (13%) patients had intraventricular bleeding while 2 (8.6%) patients had CSF leakage from the wound.
Conclusion: Endoscopic third ventriculostomy is a relatively safe and valid option for treatment obstructive hydrocephalus due to posterior fossa lesions.
Hermippos, Aspasia, and the Fates
Authors: Storey Ian 
Published: February 2020

In this paper I first survey briefly the career of Hermippos, unfairly dismissed by G. Norwood for being “unimportant as a comic poet.” He wrote parody ( parōidia) and iambics as well as comedy, producing about ten comedies over the years 435 to 415 with five victories. D. Gilula argued that “none of his comedies can be securely dated,” but I can place at least five of these plays to within a year or two of production. My principal interest lies in Fates, a comedy that can reasonably be dated to 430 and that contains a well-known lyric fragment (F 47) denouncing Perikles’ policy of Sitzkrieg in the first years of the War and a poignant description (F 48) of how Peace has yielded to War. I argue also that the “prosecution” of Aspasia by Hermippos for asebeia (Plutarch Perikles 32) belongs not to the law-courts but to a comedy and that that comedy is very likely to have been Fates.