bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1
Authors: Li Yinhui , Yan Guiling , Zhang Jie , Chen Wei , Ding Tao , Yin Yupeng , Li Minghan , Zhu Yiqing , Sun Shuhan , Yuan Ji Hang , Guo Zhiyong 
Published: November 2019

AbstractLong noncoding RNA (lncRNA) has been suggested to play an important role in a variety of diseases over the past decade. In a previous study, we identified a novel lncRNA, termed HOXA11‐AS, which was significantly up‐regulated in calcium oxalate (CaOx) nephrolithiasis. However, the biological function of HOXA11‐AS in CaOx nephrolithiasis remains poorly defined. Here, we demonstrated that HOXA11‐AS was significantly up‐regulated in CaOx nephrolithiasis both in vivo and in vitro. Gain‐/loss‐of‐function studies revealed that HOXA11‐AS inhibited proliferation, promoted apoptosis and aggravated cellular damage in HK‐2 cells exposed to calcium oxalate monohydrate (COM). Further investigations showed that HOXA11‐AS regulated monocyte chemotactic protein 1 (MCP‐1) expression in HK‐2 cell model of CaOx nephrolithiasis. In addition, online bioinformatics analysis and dual‐luciferase reporter assay results showed that miR‐124‐3p directly bound to HOXA11‐AS and the 3'UTR of MCP‐1. Furthermore, rescue experiment results revealed that HOXA11‐AS functioned as a competing endogenous RNA to regulate MCP‐1 expression through sponging miR‐124‐3p and that overexpression of miR‐124‐3p restored the inhibitory effect of proliferation, promotion effects of apoptosis and cell damage induced by HOXA11‐AS overexpression. Taken together, HOXA11‐AS mediated CaOx crystal–induced renal inflammation via the miR‐124‐3p/MCP‐1 axis, and this outcome may provide a good potential therapeutic target for nephrolithiasis.
MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
Authors: He Jianya , Ye Wen , Kou Ni , Chen Kang , Cui Bai , Zhang Xiaohong , Hu Shuhai , Liu Tingjiao , Kang Lan , Li Xiaojie 
Published: November 2019

AbstractOral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR‐29b‐3p as a guarder that suppressed migration and invasion of OSCC cells and was down‐regulated in the most invasive cells. Besides that, the invasion suppression role of miR‐29b‐3p was achieved through the IL32/AKT pathway. Thus, miR‐29b‐3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC.
EU Narratives of Regionalism Promotion to ASEAN: A Modest Turn?
Authors: Allison‐Reumann Laura 
Published: November 2019

AbstractThe promotion of regionalism is a long‐standing aim of EU foreign policy. This article argues that this aim also constitutes a strategic narrative of the EU, although it has not been framed as such thus far. The article assesses the EU's Asia policy using a strategic narrative framework, and relates this to the EU's relations with the Association of Southeast Asian Nations (ASEAN). It finds that the EU's promotion of regionalism narrative has changed over time, and that this change has primarily been triggered by the EU's reactions to ASEAN and the context of southeast Asian regionalism, and events closer to home, such as internal crises. However, it also finds that while the EU's narrative may have changed in response to the its own experiences, Brexit and other crises associated with the EU have not had a significant impact on how the EU's narrative is received, or on perceptions of the EU in ASEAN. This is primarily because ASEAN's perceptions of the EU have not always been aligned with the EU's promotion of regionalism narrative.
Ability of S100 proteins and matrix metalloproteinase‐9 to identify periodontitis in a ligature‐induced periodontitis dog model
Authors: Liu Mengmeng , Won Lee Jae , Jung Soyoung , Ji Suk , Choi Youngnim 
Published: November 2019

AbstractAimsThe present study aimed to monitor the levels of selected salivary biomarkers during the development and treatment of periodontitis and to evaluate their ability to identify periodontitis in dogs.Materials and methodsA total of 15 beagle dogs were divided into a control group (no ligature), group 1 (ligature on six teeth), and group 2 (ligature on 12 teeth). The experimental periods consisted of 8 weeks of periodontitis induction and 4 weeks of treatment. Clinical measurements and the sampling of saliva were performed every 4 weeks. The levels of S100A8, S100A9, S100A8/A9, and matrix metalloproteinase (MMP)‐9 were measured by enzyme‐linked immunosorbent assay.ResultsAll experimental animals and two control animals developed periodontitis, which was successfully treated. All salivary biomarkers were significantly increased in periodontitis with high diagnostic power (c‐index ≥ 0.944) and were able to identify animals with periodontitis on a single tooth. Whereas the levels of salivary S100A8/A9 recovered to levels in health, those of S100A8, S100A9, and MMP‐9 in periodontitis stability remained significantly higher than in health.ConclusionSalivary S100A8, S100A9, S100A8/A9, and MMP‐9 may be used for the screening of periodontitis in dogs, but with caution of other conditions that can affect their levels in saliva.
The Relationship Between Chronic Kidney Disease, Symptoms and Health‐Related Quality of Life: A Systematic Review
Authors: Yapa Harith Eranga , Purtell Louise , Chambers Shirley , Bonner Ann 
Published: November 2019

SUMMARYBackgroundPeople with chronic kidney disease (CKD) experience a wide range of symptoms due to reduced kidney function. As the disease progresses these symptoms become more burdensome and often negatively affect a person's health‐related quality of life (HRQoL).ObjectiveTo examine the evidence of symptoms and HRQoL in CKD stages 1–5 and the relationships between these.MethodsStudies published in English from January 2008 to July 2018 using six databases (PubMed, MEDLINE, CINAHL, PsycINFO, Cochrane Library and JBI Library) were searched.ResultsThirteen studies were included in this review although only three had interventional designs. By considering symptom experience and HRQoL together, four studies found that HRQoL decreased when symptoms increased. Feeling washed out, fatigue and drowsiness were found to be the most common symptoms reported. Only two studies reported follow‐up measurements although six studied how symptoms change over time. None of the studies examined the change of symptoms over time across the different CKD stages. The majority of studies showed a decline in physical HRQoL and improvement in mental HRQoL over time. Nutritional and exercise interventions showed some improvements in symptom experience and HRQoL.ConclusionsOnly four studies were found that reported the relationship between symptoms and HRQoL of those with CKD. Of these, in view of symptom experience and HRQoL together, HRQoL decreased when symptoms increased. However, more research is warranted to establish a clear understanding of the relationship between symptoms and HRQoL in CKD to enable the design of appropriate interventions.
Effect of background color and shelters on female pigmentation in the ornamental red cherry shrimp Neocaridina davidi (Caridea, Atyidae)
Authors: Tomas Ana Laura , Sganga Daniela Eliana , López Greco Laura Susana 
Published: November 2019

AbstractNeocaridina davidi, the “red cherry” shrimp, is becoming popular in trade markets because of the reddish coloration of females. The aim of this study was to analyze the impact of background substrate color, and the presence of shelters on N. davidi female pigmentation and astaxanthin content. In the first experiment juveniles were assigned to one of three treatments: white, red, or black background substrate. After 90 days, females exposed to the black background showed higher astaxanthin content and relative carapace colored area than those exposed to white and red backgrounds. The second experiment evaluated the presence of shelters with white or black backgrounds. Juveniles were assigned to one of four treatments: white background with shelters (WS), white background without shelters (WWS), black background with shelters (BS), and black background without shelters (BWS). After 90 days the presence of shelters did not influence either the color nor total astaxanthin content. Females exposed to BWS and BS had higher astaxanthin content and relative carapace colored area than those exposed to WWS and WS. Growing N. davidi with black substrates could be a low cost and easy method to improve its economic value. Furthermore, this species could be cultivated as a pigment‐enriched food source for other aquatic species.
A statistical analysis of the H/L ratio of ordinary chondrite finds and falls: A comparison of Oman finds with other populations
Authors: Kouvatsis Ioannis , Hofmann Beda A. 
Published: November 2019

AbstractHot and cold deserts have been thoroughly searched for meteorites in the past decades, which has led to a large inventory of classified meteorites. H‐ and L‐chondrites are the most abundant meteorites in all collections, and many authors used the H/L ratio as a characteristic parameter in comparing meteorite populations. H/L ratios (after pairing) vary from 0.90 in observed falls up to 1.74 in El Médano (Atacama Desert). In this study, we investigate the H/L ratio of 965 unpaired H‐ and L‐chondrites collected in Oman and compare this population with observed falls and other hot desert collections. We find a mass dependence of the H/L ratio among hot desert finds and identify mechanisms such as fragmentation during weathering and fall that have an impact on the H/L ratio. We employ the Kolmogorov–Smirnov and Mann–Whitney U statistical tests to compare the mass distributions of H‐ and L‐chondrites and to test the relationship between the similarity of mass distributions and the H/L ratio. We conclude that the variations of the H/L ratios observed in various populations are a sampling artifact resulting from secondary effects and observational bias, expressed in differences of the H and L mass distributions which are not observed in falls, and not due to variations in H/L of the meteorite flux. The H/L ratio of 0.90 observed among recent falls is considered as most representative for the overall meteorite flux, at least since the Late Pleistocene.
Maternal folic acid supplementation and infant birthweight in low‐ and middle‐income countries: A systematic review
Authors: Jonker Hannah , Capelle Noa , Lanes Andrea , Wen Shi Wu , Walker Mark , Corsi Daniel J. 
Published: November 2019

AbstractThe relationship between maternal folic acid supplementation in pregnancy and infant birthweight has not been well described in low‐ and middle‐income countries. We conducted a systematic review and meta‐analysis of the current evidence of the association between folic acid supplementation in pregnancy on three primary outcomes: the incidence of low birthweight, small for gestational age, and mean birthweight. Seventeen studies were identified, which satisfied the inclusion criteria, covering a total of 275,421 women from 13 cohort studies and four randomized controlled trials. For the primary outcome of mean birthweight (n = 9), the pooled mean difference between folic acid and control groups was 0.37 kg (95% confidence interval [CI]: 0.24 to 0.50), and this effect was larger in the randomized controlled trials (0.56, 95% CI: 0.15 to 0.97, n = 3). The pooled odds ratio was 0.59 for low birthweight (95% CI: 0.47 to 0.74, n = 10) among folic acid supplementation versus control. The pooled odds ratio for the association with small for gestational age was 0.63 (95% CI: 0.39 to 1.01, n = 5). Maternal folic acid supplementation in low‐ and middle‐income countries was associated with an increased mean birthweight of infants and decreases in the incidence of low birthweight and small for gestational age.
LGI1 antibody‐associated limbic encephalitis started from unilateral basal ganglia to medial temporal lobe and insula
Authors: Liu Xia , Omote Yoshio , Osakada Yosuke , Tadokoro Koh , Takemoto Mami , Hishikawa Nozomi , Yamashita Toru , Ohta Yasuyuki , Abe Koji 
Published: November 2019

AbstractLeucine‐rich glioma‐inactivated 1 (LGI1) antibody‐associated limbic encephalitis is a rare autoimmune encephalitis. Here, we report a 39‐year‐old woman presented with generalized tonic‐clonic seizures, night delirium, bilateral upper limb tremor, and hyponatremia. Her symptoms did not improve with initial steroid therapy, and brain magnetic resonance imaging (MRI) showed a progression of abnormalities from right basal ganglia to medial temporal lobe and insula. The presence of LGI1 antibodies in the patient's serum confirmed the clinical diagnosis. After the combined treatments of methylprednisolone, plasma exchange, and intravenous immunoglobulin, her clinical symptoms resolved completely.
Genome‐wide association study for frost tolerance in rapeseed/canola (Brassica napus) under simulating freezing conditions
Authors: Wrucke Danielle F. , Talukder Zahirul I. , Rahman Mukhlesur 
Published: November 2019

AbstractRapeseed/canola seedlings can be easily damaged by spring frost, which can rupture the cells and kill the plant. Genetic variations for frost tolerance have known to exist within rapeseed/canola gene pool. A genome‐wide association study (GWAS) was conducted using 231 diverged rapeseed/canola germplasm to find the significant markers of the freezing tolerance traits. The genotypes were obtained from 21 countries and comprised of spring, winter and semi‐winter growth types. The genotypes were evaluated in plant growth chamber under simulated freezing conditions. Highly significant genotypic variation was observed for the freezing tolerance. The best three freezing tolerant germplasms (Rubin, KSU‐10, and AR91004) were winter type, while the four most freezing susceptible germplasms (Polo Canada, Prota, Drakkar, and BO‐63) were all spring type. No geographical or growth habit type clusters were identified by structure analysis in this mixed population. One QTL was identified that was located on chromosome A02. Six freezing/abiotic stress tolerance genes have been identified in this study.
Introgression of resistance toAlternarialeaf spot from wild species into susceptible cultivated safflower
Authors: Kammili Anjani , Mandalapu Pallavi , Ponukumatla Bhavana , Ruvulapalli Durga Prasad , Sarada Chunduri 
Published: November 2019

AbstractAlternarialeaf spot (ALS) caused byAlternaria carthamiChowdhury can cause yield loss up to 90% in safflower (Carthamus tinctoriusL.) under severe conditions. Even though a definite source of ALS resistance is not available in cultivated species, a few of the wild species,viz. C. palaestinusandC. lantaus,are known to be tolerant to ALS. Therefore, an attempt was made to introgressAlternariaresistance from these species into cultivated species. F1‐F8generations of crosses (PI537632 × C. palaestinus), (C. palaestinus × PI537632), (“Nira” × C. palaestinus) and ([MS 6(O) × C. lanatus] × C. palaestinus) were screened against ALS. ALS infection (%) was recorded in field and quantified using Windias Leaf Image Analysis system. Detached leaf technique was used in laboratory to confirm resistance in interspecific selections. Six resistant and 29 moderately resistant interspecific lines resembling mostly cultivated species were developed. Inheritance of ALS resistance indicated involvement of multiple minor alleles having small effects on resistance. The identified resistant lines could provide potential source of resistance to ALS for safflower breeding programmes.
Control of graft‐versus‐host disease with rabbit anti‐thymocyte globulin, rituximab, and bortezomib in TCRαβ/CD19‐depleted graft transplantation for leukemia in children: a single‐center retrospective analysis of two GVHD‐prophylaxis regimens
Authors: Shekhovtsova Zhanna , Shelikhova Larisa , Balashov Dmitry , Zakharova Viktoria , Ilushina Maria , Voronin Kirill , Kurnikova Elena , Muzalevskii Yakov , Kazachenok Alexey , Pershin Dmitry , Novichkova Galina , Maschan Alexey , Maschan Michael 
Published: November 2019

AbstractBoth acute GVHD and chronic GVHD remain the leading cause of morbidity and death after allogeneic HSCT. We conducted a retrospective analysis comparing two GVHD‐prophylaxis regimens: 35 patients received “Regimen 1” (horse ATG, tacrolimus, and methotrexate) and 46 “Regimen 2” (rabbit ATG, rituximab, and peritransplant bortezomib). All 81 patients with a median age of 9 (0.6‐23) years with ALL (n = 31) or AML (n = 50) in complete remission received TCRαβ/CD19‐depleted transplants between May 2012 and October 2016, from 40 HLA‐matched unrelated and 41 haploidentical donors. After a median follow‐up of 3.9 years, the CI of acute GVHD II‐IV was 15% (95% CI: 7‐30) in the “Regimen 2” group and 34% (95% CI: −54) in the “Regimen 1” group, P = .05. “Regimen 2” was also more effective in the prevention of chronic GVHD; the CI at 1 year after HSCT was 7% (95% CI: 2‐19) vs 31% (95% CI: 19‐51), P = .005. The CI of relapse at 3 years adjusted for the GVHD‐prophylaxis regimen groups 31% (95% CI: 19‐51) for the “Regimen 1” vs 21% (95% CI: 11‐37) for the “Regimen 2”, P = .3. The retrospective observation suggests that the use of the rATG, rituximab, and bortezomib was associated with significantly lower rate of GVHD without the loss of anti‐leukemic activity.
Association between frailty and life satisfaction among older people in Shandong, China: the differences in age and general self‐efficacy
Authors: Qin Wenzhe , Xu Lingzhong , Sun Long , Li Jiajia , Ding Gan , Wang Qian , Zhang Jiao , Shao Hui 
Published: November 2019

BackgroundFrailty and other functional declines may be related to life satisfaction (LS) in the general elderly population. This study aims to investigate the association between frailty and LS among older individuals (age ≥60) and the impacts of age and general self‐efficacy on the relationships.MethodsUsing data from the 2017 Survey of the Shandong elderly Family Health Service, a cross‐sectional study was conducted and 7070 older people aged 60+ were analysed. LS was measured using the Satisfaction with Life Scale. A Frailty Index (ranged 0~1) was determined as a proportion of accumulated deficits over 51 categories. General self‐efficacy was measured using the Chinese version of the General Self‐Efficacy Scale. Multiple weighted linear regression was used to examine possible relationships between the research variables.ResultsThere was a negative association between frailty and LS. A dose–response‐type relationship between net income and LS was observed. The interaction between frailty and age was found to be significantly associated with LS. Frailty has a stronger negative impact on LS among the young‐old (60–69 years) than among the middle‐old (70–79 years) and old‐old (80+ years), which suggests a protective effect of ageing on LS reduction due to frailty. However, this protective effect was observed among individuals with low and medium level self‐efficacy.ConclusionsThe relationship between frailty and LS generally weaken with age. The higher level of general self‐efficacy may provide a partial buffer against the negative impact of frailty on LS. Interventions that target to prevent and manage frailty should consider being prioritised among the young‐old population. Development of self‐efficacy could serve as an important strategy to buffer the negative effect of frailty on LS among older people.
Autonomy and relatedness in early adolescent friendships as predictors of short‐ and long‐term academic success
Authors: Loeb Emily L. , Davis Alida A. , Costello Meghan A. , Allen Joseph P. 
Published: November 2019

AbstractThis study examined early adolescent autonomy and relatedness during disagreements with friends as key social competencies likely to predict academic achievement during the transition to high school and academic attainment into early adulthood. A sample of 184 adolescents was followed through age 29 to assess predictions to academic success from observed autonomy and relatedness during a disagreement task with a close friend. Observed autonomy and relatedness at age 13 predicted relative increases in grade point average (GPA) from 13 to 15, and greater academic attainment by age 29, after accounting for baseline GPA. Findings remained after accounting for peer acceptance, social competence, scholastic competence, externalizing and depressive symptoms, suggesting a key role for autonomy, and relatedness during disagreements in helping adolescents navigate challenges in the transition to high school and beyond.
Hyperspectral imaging combined with machine learning as a tool to obtain high‐throughput plant salt‐stress phenotyping
Authors: Feng Xuping , Zhan Yihua , Wang Qi , Yang Xufeng , Yu Chenliang , Wang Haoyu , Tang ZhiYu , Jiang Dean , Peng Cheng , He Yong 
Published: November 2019

SummaryThe rapid selection of salinity‐tolerant crops to increase food production in salinized lands is important for sustainable agriculture. Recently, high‐throughput plant phenotyping technologies have been adopted that use plant morphological and physiological measurements in a non‐destructive manner to accelerate plant breeding processes. Here, a hyperspectral imaging (HSI) technique was implemented to monitor the plant phenotypes of 13 okra (Abelmoschus esculentus L.) genotypes after 2 and 7 days of salt treatment. Physiological and biochemical traits, such as fresh weight, SPAD, elemental contents and photosynthesis‐related parameters, which require laborious, time‐consuming measurements, were also investigated. Traditional laboratory‐based methods indicated the diverse performance levels of different okra genotypes in response to salinity stress. We introduced improved plant and leaf segmentation approaches to RGB images extracted from HSI imaging based on deep learning. The state‐of‐the‐art performance of the deep‐learning approach for segmentation resulted in an intersection over union score of 0.94 for plant segmentation and a symmetric best dice score of 85.4 for leaf segmentation. Moreover, deleterious effects of salinity affected the physiological and biochemical processes of okra, which resulted in substantial changes in the spectral information. Four sample predictions were constructed based on the spectral data, with correlation coefficients of 0.835, 0.704, 0.609 and 0.588 for SPAD, sodium concentration, photosynthetic rate and transpiration rate, respectively. The results confirmed the usefulness of high‐throughput phenotyping for studying plant salinity stress using a combination of HSI and deep‐learning approaches.