bluuebunny/crossref_metadata_2025_split huggingface dataset:
The link between social interactions and trust recovery in customer–business relationships
Authors: da Rosa Pulga Andréia Alcântara , Basso Kenny , Viacava Keitiline Ramos , Pacheco Natália Araújo , Ladeira Wagner Junior , Dalla Corte Vitor Francisco 
Published: December 2019

AbstractTrust plays a crucial role in interpersonal relationships, including customer–company relationships, where the customer expects that a company will behave predictably in any particular situation. Companies do not always fulfill customers' expectations and thereby breach the trust relationship. To avoid negative consequences of this trust violation, companies may issue a formal apology as one possible path to regaining customer trust. In the same way, a previous social interaction, which can increase the customer's levels of oxytocin, can help to recover trust after service failures. In this study, three experiments were conducted as follows: the first manipulating a simulated social interaction with images; the second manipulating a physical social interaction, (i.e., a hug); and the third with exogenous oxytocin administration. The results showed that both physical interaction, (i.e., a hug) and simulated social interaction, (i.e., images of people interacting with each other) had a positive effect on customer trust recovery and provided support for oxytocin release as the underlying mechanism in this process. This research contributes to understanding of the link between social interactions and trust by elucidating the effects of both simulated and physical interactions on trust recovery.
Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress
Authors: Hirose Naoto , Okamoto Yuki , Yanoshita Makoto , Asakawa Yuki , Sumi Chikako , Takano Mami , Nishiyama Sayuri , Su Shao‐Ching , Mitsuyoshi Tomomi , Kunimatsu Ryo , Tanne Kazuo , Tanimoto Kotaro 
Published: December 2019

AbstractChondrocytes constantly receive external stimuli, which regulates remodeling. An optimal level of mechanical stress is essential for maintaining chondrocyte homeostasis, however, excessive mechanical stress induces inflammatory cytokines and protease, such as matrix metalloproteinases (MMPs). Therefore, excessive mechanical stress is considered to be one of the main causes to cartilage destruction leading to osteoarthritis (OA). Integrins are well‐known as cell adhesion molecules and act as receptors for extracellular matrix (ECM), and are believed to control intracellular signaling pathways both physically and chemically as a mechanoreceptor. However, few studies have focused on the roles and functions of integrins in inflammation caused by excessive mechanical stress. In this study, we examined the relationship between integrins (αVβ3 and αVβ5) and the expression of inflammatory factors under mechanical loading in chondrocytes by using an integrin receptor antagonist (cilengitide). Cilengitide suppressed the gene expression of interleukin‐1β (IL‐1β), tumor necrosis factor‐α (TNF‐α), matrix metalloproteinase‐3 (MMP‐3), and MMP‐13 induced by excessive mechanical stress. In addition, the protein expression of IL1‐β and MMP‐13 was also inhibited by the addition of cilengitide. Next, we investigated the involvement of intracellular signaling pathways in stress‐induced integrin signaling in chondrocytes by using western blotting. The levels of p‐FAK, p‐ERK, p‐JNK, and p‐p38 were enhanced by excessive mechanical stress and the enhancement was suppressed by treatment with cilengitide. In conclusion, this study revealed that excessive mechanical stress may activate integrins αVβ3 and αVβ5 on the surface of chondrocytes and thereby induce an inflammatory reaction by upregulating the expression of IL‐1β, TNF‐α, MMP‐3, and MMP‐13 through phosphorylation of FAK and MAPKs.
Ozone alleviates ischemia/reperfusion injury by inhibiting mitochondrion‐mediated apoptosis pathway in SH‐SY5Y cells
Authors: Cai Hua‐An , Tao Xi , Zheng Li‐Jun , Huang Liang , Peng Yan , Liao Ruo‐Yi , Zhu Yi‐Min 
Published: December 2019

AbstractCerebral ischemia/reperfusion (I/R) injuries are common and often cause severe complications. Ozone has been applied for protecting I/R injury in animal models of several organs including cerebra, but the detailed mechanism remains unclear. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and lactate dehydrogenase measurement were used to determine the influence of ozone on cell activity and damage of SH‐SY5Y cells. Some redox items such as catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH‐Px), and superoxide dismutase (SOD) were measured by enzyme‐linked immunosorbent assay. The mitochondrial membrane potential (ΔΨm) was determined by JC‐1 assay. Cytochrome‐c (cyt‐c) level in the cytoplasm and mitochondrion was measured by western blotting. Apoptosis was determined by flow cytometry, and some apoptosis‐related molecules were detected by quantitative real‐time polymerase chain reaction and western blotting. Ozone alleviated oxidative damage by increasing GSH‐Px, SOD, CAT, and decreasing MDA. Ozone decreased mitochondrial damage caused by I/R injury and inhibited the release of cyt‐c from mitochondrion to cytoplasm in SH‐SY5Y cells. The cell apoptosis caused by I/R was inhibited by ozone, and ozone could decrease apoptosis by increasing the ratio of Bcl‐2/Bax and inhibiting caspase signaling pathway in SH‐SY5Y cells. Ozone has the ability of maintaining redox homeostasis, decreasing mitochondrion damage, and inhibiting neurocytes apoptosis induced by I/R. Therefore, ozone may be a promising protective strategy against cerebral I/R injury.
Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
Authors: Assing Kristian , Nielsen Kaspar René , Tenstad Helene Broch , Jakobsen Marianne Antonius , Nielsen Christian , Grosen Dorthe , Hartling Ulla Birgitte 
Published: December 2019

AbstractThis case suggests a mechanistic rationale for the clinical efficacy of intravenous immunoglobulins (IVIG) in treating CD40 ligand (CD40L) deficiency associated neutropenia as it is the first reported instance of free and cell‐bound antineutrophil antibodies in a case of CD40L deficiency, accompanied by a prolonged and clinically severe neutropenia.
Molybdenum Sulfide Nanosheets Coupled with Ni2P Hollow Microspheres as an Efficient Electrocatalyst for Hydrogen Generation over a Wide pH Range Mediated by a 3D/2D Interface
Authors: Gao Caiyan , Li Zhuoqian , Wang Haiyang , Yang Yaqi , Li Baojun , Peng Zhikun , Li Jun , Liu Zhongyi 
Published: December 2019

AbstractDeveloping high activity, strong durability, and cost‐efficient electrocatalysts for the hydrogen evolution reaction (HER) is critical for the sustainable production of hydrogen energy. Herein, we have rationally designed three‐dimensional (3D) heterogeneous catalyst of hollow nickel phosphide spheres coupled with molybdenum sulfide nanosheets (Ni2P@MoS2). Benefiting from the hollow spherical structure and the coupling effects between MoS2 and Ni2P, Ni2P@MoS2 shows superior activity for hydrogen generation over a wide pH range. It displays overpotentials of 181, 269 and 535 mV in 1.0 M KOH, 0.5 M H2SO4 and 1.0 M PBS, respectively, at a current density of 10 mA cm−2. A series of characterization techniques demonstrate that the strong coupling interaction between Ni2P and MoS2 effectively optimizes the electronic structure of the Ni2P‐MoS2 3D/2D interfaces, beneficial for regulating H* adsorption energy. This work offers a novel strategy for enhancing the HER performance of metal phosphide/sulfide catalysts by constructing heterostructured materials with abundant 3D/2D interfaces.
Towards a Stronger Halogen Bond Involving Astatine: Unexpected Adduct with Bu3PO Stabilized by Hydrogen Bonding
Authors: Liu Lu , Guo Ning , Champion Julie , Graton Jérôme , Montavon Gilles , Galland Nicolas , Maurice Rémi 
Published: December 2019

AbstractThe halogen bond is a powerful tool for the molecular design and pushing the limits of its strength is of major interest. Bearing the most potent halogen‐bond donor atom, astatine monoiodide (AtI) was recently successfully probed [Nat. Chem. 2018, 10, 428–434]. In this work, we continue the exploration of adducts between AtI and Lewis bases with the tributylphosphine oxide (Bu3PO) ligand, revealing the unexpected experimental occurrence of two distinct chemical species with 1:1 and 2:1 stoichiometries. The 1:1 Bu3PO⋅⋅⋅AtI complex is found to exhibit the strongest astatine‐mediated halogen bond so far (with a formation constant of 10(4.24±0.35)). Quantum chemical calculations unveil the intriguing nature of the 2:1 2Bu3PO⋅⋅⋅AtI adduct, involving a halogen bond between AtI and one Bu3PO molecular unit plus CH⋅⋅⋅O hydrogen bonds chelating the second Bu3PO unit.
High‐Content Screening for Protein‐Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons
Authors: Mendes Tiago , Herledan Adrien , Leroux Florence , Deprez Benoit , Lambert Jean‐Charles , Kilinc Devrim 
Published: December 2019

AbstractThe proximity ligation assay (PLA) allows the detection and subcellular localization of protein‐protein interactions with high specificity. We recently developed a high‐content screening model based on primary hippocampal neurons cultured in 384‐well plates and screened a library of ∼1100 compounds using a PLA between tau and bridging integrator 1, a genetic risk factor for Alzheimer's disease. We developed image‐segmentation and spot‐detection algorithms to delineate PLA signals in the axonal network, but not in cell bodies, from confocal images acquired via a high‐throughput microscope. To compare data generated from different plates and through different experiments, we developed a computational routine to optimize the image analysis parameters for each plate and devised a range of quality‐control measures to ultimately identify compounds that consistently increase or decrease our read‐out. We provide the following protocols. © 2019 by John Wiley & Sons, Inc.Basic Protocol 1: Routine culture of rat postnatal hippocampal neurons in 384‐well platesBasic Protocol 2: Compound incubation using the high‐content screening platformSupport Protocol 1: Preparation of intermediate plates for compound screeningSupport Protocol 2: Preparation of intermediate plates for hit validation (dose‐response curves)Basic Protocol 3: Proximity ligation assay in 384‐well platesBasic Protocol 4: Image acquisition and analysisSupport Protocol 3: Optimization of analysis parametersBasic Protocol 5: Identification of hitsBasic Protocol 6: Validation of hits based on dose‐response curves
A Sensitive and Quantitative mKeima Assay for Mitophagy via FACS
Authors: Wang Chunxin 
Published: December 2019

AbstractMitophagy is a selective autophagy process that specifically removes damaged mitochondria via general autophagy. The two major recessive Parkinson's disease genes PINK1 and Parkin play essential roles in mitophagy initiation, increasing the interest in mitophagy in both basic and translational research over the past 10 years. Initially, mitophagy was measured by the loss of mitochondria either through confocal imaging or immunoblot of mitochondrial proteins such as Tom20 or COXII. Confocal imaging of mitochondria DNA loss via anti‐DNA staining is another option. All of these methods, which take considerable effort and labor, are not sensitive enough to detect early stages of mitophagy with unambiguous objectivity. The mKeima assay can be used for both confocal imaging and FACS analysis to provide a thorough picture of mitophagy with a wide dynamic range. The Keima fluorophore has bimodal excitation under neutral and acidic pH conditions. Thus, when Keima is targeted to mitochondria it can accurately reveal the formation of mitolysosomes. Here the author briefly describes the origin and history of mKeima and how it is adapted to measure mitophagy. The author presents detailed protocols for making stable cell lines for optimized mitophagy detection and discuss many parameters that might affect the assay. A troubleshooting section is also provided to discuss possible pitfalls to improve reproducibility and sensitivity of the assay. © 2019 The Authors.This article was corrected on 20 August 2022. See the end of the full text for details.Basic Protocol 1: Making stable lines expressing mito‐mKeima and YFP‐ParkinSupport Protocol: Retrovirus/lentivirus infectionBasic Protocol 2: FACS analysis of mitophagy
Population Pharmacokinetics of Paliperidone Palmitate (Once‐Monthly Formulation) in Japanese, Korean, and Taiwanese Patients With Schizophrenia
Authors: Shimizu Hiroko , Neyens Martine , De Meulder Marc , Gopal Srihari , Tsukamoto Yuko , Samtani Mahesh N. , Remmerie Bart 
Published: December 2019

AbstractThe paliperidone pharmacokinetics after intramuscular administration of once‐monthly paliperidone palmitate in Japanese patients were studied in 3 phase 1 studies and in 2 phase 3 studies performed in Japan, Korea, and Taiwan. These data (Japanese, n = 509; Korean, n = 31; Taiwanese, n = 47) were used to describe the paliperidone palmitate pharmacokinetics in Japanese, to compare with non‐Japanese, and to validate the historical population pharmacokinetic (Pop‐PK) model for paliperidone palmitate, developed using data from studies in patients with schizophrenia outside Japan. The final historical Pop‐PK model, including all significant patient covariates of Japanese studies, was used to simulate paliperidone plasma concentration–time data using nonlinear mixed effects, followed by comparison with actual data. Visual predictive checks displayed considerable overlap between predicted and actual plasma concentrations; the majority of observations were within the 90% prediction interval. Japanese, Korean, and Taiwanese patients had comparable plasma concentrations. Covariate distributions demonstrated comparatively lower median body mass index in Japanese, Korean, and Taiwanese patients versus rest‐of‐world population. Prediction errors for the data set used for external validation were within cutoff values, confirming accuracy/precision of the model. Paliperidone pharmacokinetics were adequately predicted for Japanese studies using the historical Pop‐PK model, confirming its robustness. Pharmacokinetics in Japanese, Korean, and Taiwanese patients with schizophrenia were comparable with rest‐of‐world population.
Efficacy of cognitive behavioural therapy for internet gaming disorder
Authors: Han Jiwon , Seo Yesul , Hwang Hyunchan , Kim Sun Mi , Han Doug Hyun 
Published: December 2019

AbstractCognitive behavioural therapy (CBT) is considered to be an effective treatment for internet gaming disorder (IGD). This study examined the effectiveness of CBT in treating impulsivity, anxiety, avoidance, and family and environmental problems in patients. A total of 101 patients completed the CBT programme, and 104 completed the supportive therapy. The CBT programme consisted of fourteen 90‐min sessions with one therapist and four to five patients, once or twice a week. The supportive therapy group visited a psychiatric outpatient department once or twice a week until they completed 14 visits. Outcomes were measured in terms of improvement in IGD, psychological symptoms, and social interaction. The CBT group (improvement: 67 [66.3%] versus non‐improvement: 34 [33.7%]) showed more improvement in IGD compared with the supportive therapy group. The CBT group also showed a greater decrease in internet addiction, anxiety, impulsivity, and social avoidance. In the CBT group, among patients who improved, the greatest improvements were in internet addiction, attention, depression, anxiety, impulsivity, social avoidance, and family cohesion. Our CBT programme may be more effective than supportive therapy with regard to improvement in IGD symptoms by controlling anxiety, impulsivity, and social avoidance. In addition, CBT‐related improvements in patients with IGD could be enhanced by controlling anxiety, social avoidance, and family cohesion.
Reporting as a booster of the corporate social performance effect on corporate reputation
Authors: Pérez‐Cornejo Clara , de Quevedo‐Puente Esther , Delgado‐García Juan Bautista 
Published: December 2019

AbstractCorporate social performance (CSP) is one of the main drivers of corporate reputation. The main aim of this study is to analyze the moderating effect of corporate social responsibility (CSR) reporting quality on the relation of CSP and corporate reputation through two effects. First, it may enhance the firm's credibility because CSR reporting favors CSP consistency by reducing managers' CSR discretion and easing CSP comparability along the time. Second, it may increase the visibility of CSR actions beyond direct stakeholders involved in them. Analyzing an international sample of 132 companies from nine countries for the period 2011–2016, we show that all of the CSP dimensions (social, environmental, and economic) positively affect corporate reputation. We also find that good CSR reporting quality increases the intensity of the environmental and social performance effects on corporate reputation. Results provide a new perspective of the role CSR reporting quality that managers have to deal to get better impacts of CSP on corporate reputation.
Voltammetric Determination of Arsenic with Modified Glassy Carbon Electrode
Authors: Stanković Anamarija , Kajinić Žana , Turkalj Jelena Vešligaj , Romić Željka , Sikirić Maja Dutour , Asserghine Abdelilah , Nagy Geza , Medvidović‐Kosanović Martina 
Published: December 2019

AbstractIn this study, glassy carbon electrode modified with nano gold‐crystal violet film has been used to detect arsenite (As (III)) in a model system and in groundwater samples. The modified electrode was characterized by scanning electrochemical microscopy (SECM) and electrochemical impedance spectroscopy (EIS). Using voltammetric measuring technique, linear response was obtained in a concentration range of 2.0–22.0 μM. The arsenite concentrations in groundwater samples varied between 2.4 μM to 4.8 μM. The sensitivity of the modified electrode for As (III) detection was 5.6 μA/μM cm2 and 0.8 μM concentration was found as lower limit of detection (LOD). The accuracy of the method was checked with standard method anodic stripping voltammetry (ASV). Groundwater samples were characterized with dynamic (DLS) and electrophoretic (ELS) light scattering measurements which have shown that particles present in different samples differ in size distribution and zeta potential which did not interfere with As (III) detection.
Hidden Markov random field models applied to color homogeneity evaluation in dyed textile images
Authors: Freguglia Victor , Garcia Nancy L. , Bicas Juliano L. 
Published: December 2019

AbstractColor is one of the most important features in any textile material. Due to its competitive price, most of the colorants currently used for textile dyeing are synthetic, originated from nonrenewable sources, and highly pollutant. There is an increasing interest for natural processes to dye fabrics. When new textile dyeing technologies are developed, evaluating the quality of these techniques involves measuring the resulting color homogeneity using digital images. The presence of a texture effect, caused by the interlacing of warp and weft yarns, as well as small displacement of the fabric, creates a sophisticated dependence structure in pixels coloring. A random effects model is employed in order to separate the signal from the dyeing effect (fixed effect described by smooth functions) and warp and weft texture effect (Gaussian mixture driven by a hidden Markov random field), allowing an evaluation of color homogeneity in dyed textiles regardless of the effect of the texture.
Resource allocation in 5G heterogeneous networks with downlink‐uplink decoupled access
Authors: Khan Humayun Zubair , Ali Mudassar , Naeem Muhammad , Rashid Imran , Imran Muhammad 
Published: December 2019

AbstractFifth‐generation (5G) heterogeneous network (HetNet) with downlink (DL) and uplink (UL) decoupled cell association strategy is a promising solution to challenges faced in fourth‐generation (4G) HetNet, ie, mitigating interference, addressing traffic imbalances, and enhanced sum‐rate. This work carries out performance analysis of 4G HetNet with DL and uplink coupled (DUCo) access scheme vs 5G HetNet with DL and UL decoupled (DUDe) access scheme employing outer approximation and heuristic algorithms. First, a mathematical model, mixed integer nonlinear programming (MINLP) problem, is formulated for DUCo access and DUDe access schemes considering cell association, addressing user traffic imbalances, mitigating interference, and sum‐rate maximization in HetNet. Then, the formulated problem is solved, employing outer approximation algorithm (OAA) to find near optimal solution. Similarly, heuristic algorithms are developed for DUCo access and DUDe access schemes considering cell association, addressing user traffic imbalances, mitigating interference, and sum‐rate maximization in HetNet. Detailed performance analysis of DUCo access and DUDe access schemes is done by comparing results employing OAA and heuristic algorithms. Simulation results have shown that proposed DUDe access scheme outperforms DUCo access scheme in HetNet in term of cell association, addressing user traffic imbalances, mitigating interference, and sum‐rate maximization.
Flame‐retardant compounds for polymeric materials from an abundantly available, renewable biosource, castor oil
Authors: Howell Bob A. , Ostrander Eric A. 
Published: December 2019

SummaryCastor oil is a triglyceride extracted from the seed (castor bean) of the castor plant. This plant will thrive on relatively poor soil and in an arid climate. The oil is nonedible but is produced annually in large volume to be converted to biodiesel (largely for the European market). The oil contains both unsaturation and hydroxyl functionality that may be utilized for conversion to flame retarding materials. A series of phosphorus esters has been generated from castor oil. All display good flame retardancy in the diglycidyl ether of bisphenol A (DGEBA) epoxy resin. Introduction of bromine at the double bond generally enhances the flame retardancy of these esters.
Prediction of bruise volume propagation of pear during the storage using soft computing methods
Authors: Razavi Mahsa Sadat , Golmohammadi Abdollah , Sedghi Reza , Asghari Ali 
Published: December 2019

AbstractBruises occur under both static and dynamic loadings when the imposed stress on fruit goes over the failure stress of the fruit tissue. Bruise damage is the main reason for fruit quality loss. In this study, the potential of artificial neural network (ANN), adaptive neuro‐fuzzy inference system (ANFIS), and multiple regression (MR) techniques to predict bruise volume propagation of pears during the storage time was evaluated. For this purpose, at first, the radius of curvature at loading region was obtained. Samples were divided into five groups and subjected to five force levels. Then, they were kept under storage conditions and at 7‐time intervals after loading tests, bruise volume was calculated using magnetic resonance imaging (MRI) and image processing techniques. Force, storage time, and radius of curvature at loading region were employed as input variables, and bruise volume (BV) was considered as output in the developed models. Multilayer perceptron (MLP) artificial neural network with three layers that includes an input layer (three neurons), two hidden layers (two and nine neurons), and one output layer was used. For the evaluation of models, three criteria (RMSE, VAF, and R2) were calculated. ANN and MR gave the highest and lowest correlation between predicted and actual values, respectively. These results indicate that the ANN techniques can be used to predict pear bruising propagation in storage time.