bluuebunny/crossref_metadata_2025_split huggingface dataset:
Headache at the Chronic Stage of Ischemic Stroke
Authors: Carvalho Dias Mariana , Martins Teresa , Basílio Gonçalo , Lucas Neto Lia , Caeiro Lara , Ferro José M. , Verdelho Ana 
Published: February 2020

BackgroundHeadache in ischemic stroke survivors after the acute stage is incompletely described.ObjectiveWe aimed to prospectively describe the characteristics of headache and the predictors of headache at the chronic stage after ischemic stroke.MethodsWe conducted a prospective observational cohort study including 102 acute ischemic stroke patients admitted to a Stroke Unit. Patients were interviewed at the acute and the chronic stage (12 months after stroke). Characteristics of those headaches were collected using a previously validated headache questionnaire enabling headache classification following the International Headache Society criteria. Pre‐stroke headache history was registered using the same instrument.ResultsForty‐five patients out of 89 with completed follow‐up (51%) reported headache at the chronic stage. In most of the patients, headache was sporadic, mild, pressure‐like, with a duration of minutes to hours, with characteristics of tension‐type headache in 51% (n = 23/45). Headache was a reactivation of pre‐stroke headache in 33% (n = 15/45), different from pre‐stroke headache in 44% (n = 20/45), and of new‐onset in 22% (n = 10/45). Only 1 patient had a new‐onset headache at the acute stage that persisted with the same characteristics at the chronic stage.Pre‐stroke headache (OR = 5.3; 95% CI [2.01‐13.98] P = .001) and female sex (OR = 3.5; 95% CI [1.3‐9.4] P = .013) predicted headache at the chronic stage after stroke, controlling for age, severity, and location of stroke.ConclusionsHeadache in ischemic stroke survivors at the chronic stage is more frequent in women and in patients with pre‐stroke headache. It is most frequently a headache with different characteristics of the pre‐stroke headache and only rarely a new‐onset headache starting at the acute stage and persisting at the chronic stage.
The earliest stage of Izu rear‐arc volcanism revealed by drilling at Site U1437, International Ocean Discovery Program Expedition 350
Authors: Sato Tomoki , Miyazaki Takashi , Tamura Yoshihiko , Gill James B. , Jutzeler Martin , Senda Ryoko , Kimura Jun‐Ichi 
Published: February 2020

AbstractThe International Ocean Discovery Program Expedition 350 drilled between two Izu rear‐arc seamount chains at Site U1437 and recovered the first complete succession of rear‐arc rocks. The drilling reached 1806.5 m below seafloor. In situ hyaloclastites, which had erupted before the rear‐arc seamounts came into existence at this site, were recovered in the deepest part of the hole (∼15–16 Ma). Here it is found that the composition of the oldest rocks recovered does not have rear‐arc seamount chain geochemical signatures, but instead shows affinities with volcanic front or some of the extensional zone basalts between the present volcanic front and the rear‐arc seamount chains. It is suggested that following the opening of the Shikoku back‐arc Basin, Site U1437 was a volcanic front or a rifting zone just behind the volcanic front, and was followed at ~ 9 Ma by the start of rear‐arc seamount chains volcanism. This geochemical change records variations in the subduction components with time, which might have followed eastward moving of hot fingers in the mantle wedge and deepening of the subducting slab below Site U1437 after the cessation of Shikoku back‐arc Basin opening.
A review of applicant faking in selection interviews
Authors: Melchers Klaus G. , Roulin Nicolas , Buehl Anne‐Kathrin 
Published: February 2020

AbstractInterviews are commonly used for selection but research on interview faking only gained momentum relatively recently. We review both theoretical and empirical work on prevalence, antecedents, processes, and effects of interview faking. Most applicants fake at least to some degree. Personality (e.g., Conscientiousness, Honesty‐humility, the Dark Triad) and attitudes toward faking substantially correlate with faking behaviors. Research concerning applicants' ability, interview structure components, or contextual factors is limited. Furthermore, the impact of faking on interview ratings is mixed and effects on criterion‐related validity are not consistently negative. Finally, the detection of faking seems hardly possible and there are limited options available to reduce interview faking. Throughout our review, we describe important gaps and derive suggestions and propositions for future research.
Robotics for catheter ablation of cardiac arrhythmias: Current technologies and practical approaches
Authors: Bassil Guillaume , Markowitz Steven M. , Liu Christopher F. , Thomas George , Ip James E. , Lerman Bruce B. , Cheung Jim W. 
Published: February 2020

AbstractRobotic technology has emerged as an important tool to facilitate catheter ablation of arrhythmias. Robotic cardiac electrophysiology technology includes remote magnetic navigation and manual robotic navigation. Robotics can confer advantages with respect to ease of catheter manipulation in anatomically challenging spaces, minimization of fluoroscopic exposure to both patients and operators, and reduction in operator fatigue. This review provides a comprehensive summary of robotic electrophysiology technology, its practical applications and its safety and efficacy for targeting cardiac arrhythmias.
IL‐22 produced by Th22 cells aggravates atherosclerosis development in ApoE−/− mice by enhancing DC‐induced Th17 cell proliferation
Authors: Shi Lei , Ji Qingwei , Liu Ling , Shi Ying , Lu Zhengde , Ye Jing , Zeng Tao , Xue Yan , Yang Zicong , Liu Yu , Lu Jianyong , Huang Xinshun , Qin Qiuwen , Li Tianzhu , Lin Ying‐zhong 
Published: February 2020

AbstractTh22 cells are a novel subset of CD4+ T cells that primarily mediate biological effects through IL‐22, with both Th22 cells and IL‐22 being closely associated with multiple autoimmune and chronic inflammatory diseases. In this study, we investigated whether and how Th22 cells affect atherosclerosis. ApoE−/− mice and age‐matched C57BL/6J mice were fed a Western diet for 0, 4, 8 or 12 weeks. The results of dynamic analyses showed that Th22 cells, which secrete the majority of IL‐22 among the known CD4+ cells, play a major role in atherosclerosis. ApoE−/− mice fed a Western diet for 12 weeks and administered recombinant mouse IL‐22 (rIL‐22) developed substantially larger plaques in both the aorta and aortic root and higher levels of CD3+ T cells, CD68+ macrophages, collagen, IL‐6, Th17 cells, dendritic cells (DCs) and pSTAT3 but lower smooth muscle cell (SMC) α‐actin expression than the control mice. Treatment with a neutralizing anti–IL‐22 monoclonal antibody (IL‐22 mAb) reversed the above effects. Bone marrow‐derived DCs exhibited increased differentiation into mature DCs following rIL‐22 and ox‐LDL stimulation. IL‐17 and pSTAT3 were up‐regulated after stimulation with IL‐22 and ox‐LDL in cells cocultured with CD4+ T cells and mature DC supernatant, but this up‐regulation was significantly inhibited by IL‐6mAb or the cell‐permeable STAT3 inhibitor S31‐201. Thus, Th22 cell‐derived IL‐22 aggravates atherosclerosis development through a mechanism that is associated with IL‐6/STAT3 activation, DC‐induced Th17 cell proliferation and IL‐22–stimulated SMC dedifferentiation into a synthetic phenotype.
KRT8 phosphorylation regulates the epithelial‐mesenchymal transition in retinal pigment epithelial cells through autophagy modulation
Authors: Miao Qi , Xu Yufeng , Yin Houfa , Zhang Huina , Ye Juan 
Published: February 2020

AbstractProliferative vitreoretinopathy (PVR) is a severe ocular disease which results in complex retinal detachment and irreversible vision loss. The epithelial‐mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is considered to be critical in the pathogenesis of PVR. In this study, we focused on the potential impact of keratin 8 (KRT8) phosphorylation and autophagy on TGF‐β2–induced EMT of RPE cells and explored the relationship between them. Using immunofluorescence and Western blot analysis, the co‐localization of KRT8 and autophagy marker, as well as the abundance of phosphorylated KRT8 (p‐KRT8) expression, was observed within subretinal and epiretinal membranes from PVR patients. Moreover, during TGF‐β2–induced EMT process, we found that p‐KRT8 was enhanced in RPE cells, which accompanied by an increase in autophagic flux. Inhibition of autophagy with pharmacological inhibitors or specific siRNAs was associated with a reduction in cell migration and the synthesis of several EMT markers. In the meantime, we demonstrated that p‐KRT8 was correlated with the autophagy progression during the EMT of RPE cells. Knockdown the expression or mutagenesis of the critical phosphorylated site of KRT8 would induce autophagy impairment, through affecting the fusion of autophagosomes and lysosomes. Therefore, this study may provide a new insight into the pathogenesis of PVR and suggests the potential therapeutic value of p‐KRT8 in the prevention and treatment of PVR.
Habitat use, movement and activity of two large‐bodied native riverine fishes in a regulated lowland weir pool
Authors: Koster Wayne M. , Dawson David R. , Kitchingman Adrian , Moloney Paul D. , Hale Robin 
Published: February 2020

AbstractThe construction of dams and weirs, and associated changes to hydrological and hydraulic (e.g., water level and velocity) characteristics of rivers is a key environmental threat for fish. These multiple stressors potentially can affect fish in a variety of ways, including by causing changes in their movement, habitat use and activity. Understanding how and why these changes occur can inform management efforts to ameliorate these threats. In this context, we used acoustic telemetry to examine habitat use, longitudinal movement and activity of two lowland river fishes, Murray cod Maccullochella peelii and golden perch Macquaria ambigua, in a weir pool environment in south‐eastern Australia. We compared our results to published studies on riverine populations to determine if their behaviours are similar (or not). We show that M. peelii and M. ambigua in a weir pool exhibited some similar behaviours to conspecific riverine populations, such as strong site fidelity and use of woody habitat for M. ambigua. However, some behaviours, such as large‐scale (tens–hundreds of kilometres) movements documented for riverine populations, were rarely observed. These differences potentially reflect flow regulation (e.g., stable water levels, loss of hydraulic cues) in the weir pool. The two species also exhibited contrasting responses to dissolved oxygen conditions in the weir pool, which may reflect differences in their life history. Overall, this study shows that although some aspects of these two native fishes' life history can continue despite flow regulation, other aspects may change in weir pools, potentially impacting on long‐term population persistence.
Sex Differences in Dementia Primary Care Performance and Health Service Use: A Population‐Based Study
Authors: Sourial Nadia , Vedel Isabelle , Godard‐Sebillotte Claire , Etches Jacob , Arsenault‐Lapierre Genevieve , Bronskill Susan E. 
Published: February 2020

OBJECTIVESGrowing evidence points to underlying sex differences in the risk factors and clinical presentation of dementia. It is unclear, however, whether sex differences also exist in the management and healthcare utilization of persons with dementia. We compared primary care performance and health service use indicators for newly identified men and women with dementia in Ontario, Canada, over a 12‐year period.DESIGNPopulation‐based, repeated cohort study between 2002 and 2014.SETTINGOntario, Canada.PARTICIPANTSA total of 318 350 community‐dwelling adults, aged 65 years and older, newly identified with dementia, followed for up to 1 year.MEASUREMENTSEighteen indicators of primary care performance and health service use were assessed.RESULTSApproximately 60% of the study population were women. Few differences in the indicators were observed between sexes, although men had fewer diagnoses first recorded by the family physician, more visits to noncognition specialists, less use of home care, more hospitalizations and readmissions, and longer discharge delays. Most indicators remained relatively stable over time for both men (median relative change = 13.7%; interquartile range [IQR] = 4.5%‐29.7%) and women (median relative change = 15.7%; IQR = 5.9%‐31.5%). Notable improvements over time for both sexes included access to an interprofessional primary care team, use of home care, and decreased use of long‐term care. Areas of worsening included a higher occurrence of emergency department visits, lower continuity of care, and longer discharge delays.CONCLUSIONThese findings raise awareness on the similarities and differences in management and health system use for men and women newly diagnosed with dementia, particularly the imbalance in hospital and home care use. As health systems continue to adapt to meet the needs of the growing dementia population, policy makers and clinicians should be mindful to develop care plans and interventions that consider the influence of sex on the need for services. J Am Geriatr Soc 68:1056–1063, 2020
The Brassica napus GATA transcription factor BnA5.ZML1 is a stigma compatibility factor
Authors: Duan Zhiqiang , Zhang Yatao , Tu Jinxing , Shen Jinxiong , Yi Bin , Fu Tingdong , Dai Cheng , Ma Chaozhi 
Published: February 2020

AbstractSelf‐incompatibility (SI) is a genetic mechanism that rejects self‐pollen and thus prevents inbreeding in some hermaphroditic angiosperms. In the Brassicaceae, SI involves a pollen‐stigma recognition system controlled by a single locus known as the S locus, which consists of two highly polymorphic genes that encode S‐locus cysteine‐rich protein (SCR) and S‐receptor kinase (SRK). When self‐pollen lands on the stigma, the S‐haplotype‐specific interaction between SCR and SRK triggers SI. Here, we show that the GATA transcription factor BnA5.ZML1 suppresses SI responses in Brassica napus and is induced after compatible pollination. The loss‐of‐function mutant bna5.zml1 displays reduced self‐compatibility. In contrast, overexpression of BnA5.ZML1 in self‐incompatible stigmas leads to a partial breakdown of SI responses, suggesting that BnA5.ZML1 is a stigmatic compatibility factor. Furthermore, the expression levels of SRK and ARC1 are up‐regulated in bna5.zml1 mutants, and they are down‐regulated in BnA5.ZML1 overexpressing lines. SRK affects the cellular localization of BnA5.ZML1 through direct protein–protein interaction. Overall, our findings highlight the fundamental role of BnA5.ZML1 in SI responses in B. napus, establishing a direct interaction between BnA5.ZML1 and SRK in this process.
The effect of duration of pressure on bruising and pain in the subcutaneous heparin injection site
Authors: Yılmaz Dilek , Düzgün Fatma , Durmaz Havva , Çinar Hava Gökdere , Dikmen Yurdanur , Kara Habibe 
Published: February 2020

AbstractAimThe aim of this study was to determine the effect on pain and bruising of pressure applied for different durations after subcutaneous heparin injection.MethodsThis research was a quasi‐experimental study. The research was performed with 60 patients. Two different injection techniques were applied at an interval of 24 hr to each patient taking part in the study. Method A: after the low molecular weight heparin (LMWH) injection, pressure was applied with dry cotton for 10 s directly after the needle was withdrawn. Method B: after the LMWH injection, pressure was applied with dry cotton for 60 s directly after the needle was withdrawn. After the injection process was completed, the dimension of the bruising formed were evaluated. Also, after the injection process was completed, the patients were asked to show on a visual analog scale the severity of pain felt during the injection. Statistical analysis of the research data was performed with the statistics package IBM SPSS 22.0. The Wilcoxon signed rank test and the Mann–Whitney U test were used in the analysis of the data.ResultsThe results of the statistical analysis showed no statistically significant difference between the mean size of bruising and pain level according to the duration of pressure applied to the injection area (p > .05).ConclusionsIt was concluded in this study that the duration of pressure applied to the injection site after subcutaneous LMWH injection did not affect the size of bruising or the severity of pain, and, unlike in the literature, that 60 s of applied pressure did not have a positive effect. Also, it was found that gender had an effect on the formation of bruising and the severity of pain, and body mass index had an effect on pain severity. Ten seconds of pressure applied to the injection site after subcutaneous LMWH injection may be enough to reduce complications.
Towards an agrarian question of circulation: Walmart's expansion in Chile and the agrarian political economy of supply chain capitalism
Authors: Arboleda Martín 
Published: February 2020

AbstractThe central role that infrastructures of circulation and connectivity—logistical, financial, and digital—have come to perform in the reproduction of agro‐food systems calls for an expanded conception of agriculture that integrates dialectically the production of economic value and its subsequent realization in the sphere of exchange. Through the case of Walmart's expansion in Chile, and on the basis of a critical theorization of the circulation of capital, this paper proposes an agrarian question of circulation in which the apparently distinct realms of food production, transport, storage, and consumption are brought together into a contradictory and yet unitary whole. The case of Walmart Chile is illustrative of how the reconfiguration of spaces of urban mass consumption and the organizational restructuring of agro‐industrial hinterlands constitute each other in intricate ways. An agrarian question of circulation, the paper concludes, bears important political implications for rethinking the scope and extent of contemporary discussions on agrarian reform being put forward by transnational rural organizations.
Thriving in the New Normal: The HR Microfoundations of Capabilities for Business Model Innovation. An Integrated Literature Review
Authors: Loon Mark , Otaye‐Ebede Lilian , Stewart Jim 
Published: February 2020

AbstractFirms need to respond to the increasing competition and change of the current New Normal environment by being more innovative, and especially in developing new business models. This paper seeks to explore how microfoundations, particularly with respect to human resource management, play a key role in facilitating innovation in business models through the development of key needed capabilities. Four themes are identified with respect to business model innovation (BMI) in the New Normal: BMI as an enabler to create and operate across industries and product‐markets; BMI as a mechanism for firms to better navigate changing institutional landscapes; BMI as giving rise to business model portfolios; and concurrent and cumulative innovations that can lead to BMI. This paper also develops a conceptual framework that presents a synoptic view of the five essential capabilities for BMI, which include analogical reasoning, sensemaking, dynamic capabilities, organisational ambidexterity, and organisational learning. Finally, it is shown how the microfoundations of a bespoke, development‐oriented BMI HR architecture can support the advancement of these capabilities and thus contribute to the strategic HR literature.
Contribution analysis of sensory cues to oil/fat perception
Authors: Glumac Miodrag , Chen Jianshe 
Published: February 2020

AbstractOil/fat perception is an important subject of food science research. Various scientific theories have risen over the years about the mechanisms of oil/fat perception, but fundamental knowledge is still lacking. In particular, the dominating sensory cue(s) eliciting oil/fat perception is still up to debate in literature. In this study, 30 participants were recruited to test six samples (three natural oil/fats and three constituted) using three senses (smell, taste, and tactile). Responses showed that natural oil/fats were perceived as such with multimodal way of sensing. Texture and aroma cues played a bigger role compared to taste. Our findings suggest that aroma and texture and multimodal sensation are the mechanisms of oil/fat detection, while taste alone did not illicit sensations of oil/fat.Practical ApplicationsInformation provided here deals with contribution of different senses to six model compounds, giving new insight for human oil/fat perception. We consider these findings important for food scientists working in academia and industry alike. In order to keep consumer sensory satisfaction, food containing oil/fat must be designed to elicit preferable sensory responses. Our experiments were on model compounds, but when dealing with other food types either emulsions or liquid food matrices containing fat will be perceived in a similar manner.
Breaking Surface Feature Continuity of Previewed Mask Reinstates Object Substitution Masking12
Authors: Hirose Nobuyuki , Hattori Shota , Mori Shuji 
Published: February 2020

AbstractPerception of a briefly presented target is impaired when a sparse surrounding mask (e.g., four‐dot) persists after target offset compared to when the target and mask offset together (i.e., object substitution masking [OSM]). Previous studies have reported a mask preview effect in which OSM is largely attenuated by prior presentation of the mask. Here, we investigated how breaking object continuity of the previewed mask affects the mask preview effect. Introducing an abrupt surface color change of the previewed mask at target onset disrupted the beneficial effect of mask preview, that is, OSM was reinstated (Experiment 1). The masking induced by mask color change exhibited the same two characteristics as conventional OSM: target location specificity and non‐necessity of voluntary attention to the mask (Experiment 2). These results suggest that a sudden change in surface color breaks object continuity of the previewed mask and causes the mask to be represented as a new one, which triggers OSM anew.
The Meteoritical Bulletin, No. 107
Authors: Gattacceca Jérôme , Mccubbin Francis M. , Bouvier Audrey , Grossman Jeffrey 
Published: February 2020

AbstractMeteoritical Bulletin 107 contains 2714 meteorites including 16 falls (Aba Panu, Ablaketka, Andila, Gueltat Zemmour, Hamburg, Karimati, Mahbas Arraid, Mangui, Mazichuan, Mukundpura, Ozerki, Parauapebas, Renchen, San Pedro de Urabá, Sokoto, Tintigny), with 2226 ordinary chondrites, 168 HED achondrites, 132 carbonaceous chondrites (including 41 CM, 34 CV, 26 CO, 21 CK, 4 CR, 5 ungrouped), 43 ureilites, 30 iron meteorites (including 2 ungrouped), 29 lunar meteorites, 22 Martian meteorites, 16 primitive achondrites (including 3 brachinites), 12 Rumuruti chondrites, 9 enstatite chondrites, 7 ungrouped achondrites, 6 pallasites, 5 mesosiderites, 3 enstatite achondrites, 3 ungrouped chondrites, and 2 angrites. 1569 meteorites are from Antarctica, 835 from Africa, 206 from South America, 62 from Asia, 21 from North America, 11 from unknown locations, 8 from Europe (including one from Russia), and 1 from Oceania.