bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Aging-Related Tumor Microenvironment Changes Could Worsen The Prognosis of GBM Patients
Authors: Song Hongwang , Fu Xiaojun , Wu Chenxing , Li Shouwei 
Published: July 2020

Abstract

Background: Glioblastoma multiforme (GBM) is the most malignant tumor in human brain, with highly heterogeneity among different patients. Age could function as an incidence and prognosis risk factor for many tumors.Method: A series of bioinformatic experiments were conducted to evaluate the differences of incidence, differential expressed genes, enriched pathways with the data from Surveillance, Epidemiology, and End Results (SEER) program, the cancer genome atlas (TCGA) and Chinese glioma genome atlas (CGGA) project.Results: We discovered in our present study that distinct difference of incidence and prognosis of different aged GBM patients. By a series of bioinformatic method, we found that the tumor associated fibroblasts (TAFs) was the most crucial tumor microenvironment (TME) component that led to this phenomenon. Epithelial-mesenchymal transition (EMT) could be the mechanism by which TAFs regulate the progression of GBM. Conclusion: We have proposed a close correlation between age and GBM incidence and prognosis, and propose the underlying mechanism behind this correlation by mining different databases, which laid the foundation for future research.
Optimizing replenishment base on order structure in crane &amp; shuttle based storage and retrieval system
Authors: MA Wenkai , WANG Yanyan , HU Jinchang , WU Yaohua 
Published: July 2020

Abstract
A new automatic warehouse sorting system, the crane & shuttle based storage and retrieval system (C&SBS/RS), is proposed in this paper. In C&SBS/RS, the crane-based storage and retrieval system (CBS/RS) in the pallet storage area provides the pallets picking, the shuttle-based storage and retrieval system (SBS/RS) in the tote storage area handles the cases and items picking. When the inventory in SBS/RS is lower than safety stock, SBS/RS initiates replenishment transaction. Besides, the order matrix is proposed to study order structure parameters, such as the order density, the order strength, the wave size and so on. Moreover, this paper analyzes the influence of order structure on the replenishment with four evaluation parameters, e.g., the workload of CBS/RS and SBS/RS, the number of used storage position in SBS/RS, the replenishment time. Numerical experiments are carried out to analysis the impact of the wave size and the proportion of high turnover SKU on those four evaluation parameters under multiple order structure, which is to help warehouse operation manager decide replenishment strategy parameters.
Guidance of antibiotic treatment for urinary tract infections in the early postoperative phase after Kidney Transplantation
Authors: Strohäker Jens Karl Hugo , Nadalin Silvio , Königsrainer Alfred , Bachmann Robert 
Published: July 2020

Abstract
Purpose: Urinary tract infections are the most common infections early after kidney transplantation. The goals of this study were to evaluate our perioperative antibiotic protocol and risk factors for the occurrence of urinary tract and its effect on the early graft function. We evaluated laboratory alterations during episodes of UTI regarding their potential to guide treatment.Methods: Retrospective single-center analysis of all kidney transplant recipients of an academic transplant center between 2015 and 2017.Results: 96 patients were included in the study. Overall, in 22 patients a asymptomatic bacteriuria (ASB) was detected and 33 patients developed a urinary tract infection (UTI). Gram-negative UTIs appeared earlier than gram-positive UTIs. The most common lab findings during UTI were leukocytosis and CRP increase, both more common in gram-negative UTI (p .00 & .03). All complicated UTIs were caused by gram-negative bacteria (p .00). No difference in UTIs was seen between perioperative antibiotic regimens. Patients that suffered from UTIs showed less favorable graft function at discharge (GFR 43 vs 52 ml / min, p .03).Conclusion: UTIs are associated with worse graft functions while ASBs are not. Whether UTIs are caused by or lead to decreased graft function is still unclear. Proper gram-negative coverage is needed in cases of complicated UTIs or severe laboratory findings. Perioperative antibiotic regimens appear to have no beneficial influence on the incidence of UTIs.
A Cas-Embedding Strategy for Minimizing Off-Target Effects of DNA Base Editors
Authors: Liu Yajing , Zhou Changyang , Huang Shisheng , Dang Lu , Wei Yu , He Jun , Zhou Yin’s , Mao shaoshuai , Tao Wanyu , Zhang Yu , Yang Hui , Huang Xingxu , chi tian 
Published: July 2020

Abstract
DNA base editors, typically comprising editing enzymes fused to the N-terminus of nCas9, display off-target effects on DNA and/or RNA, which have remained a obstacle to their clinical applications. Off-target edits are typically countered via rationally designed point mutations, but the approach is tedious and not always effective. Here, we report that the off-target effects of both A>G and C>T editors can be dramatically reduced without compromising the on-target editing simply by inserting the editing enzyme into the middle of nCas9 at tolerant sites identified using a transposon-based genetic screen. Furthermore, employing this Cas-embedding method, we have created a highly specific editor capable of efficient C>T editing at methylated and GC-rich sequences.
A Novel Prognostic Model In Oral Squamous Carcinoma: The Functions And Prognostic Values Of Rna Binding Proteins
Authors: Lu Yingjuan , Yan Yongcong , Liu Mo , Liang Yancan , Ye Yushan , Cheng Weiqi , Li Jinsong , Jiao Jiuyang , Chang Shaohai 
Published: July 2020

Abstract
Background: The biological roles and clinical significance of RNA-binding proteins (RBPs) in oral squamous cell carcinoma (OSCC) are not fully understood. We investigated the prognostic value of RBPs in OSCC by several bioinformatic strategies.Methods: OSCC data were obtained from a public online database, the Limma R package was used to identify differentially expressed RBPs, and functional enrichment analysis was performed to elucidate the biological functions of the above RBPs in OSCC. We performed protein-protein interaction (PPI) network and Cox regression analyses to extract prognosis-related hub RBPs. Next, we established and validated a prognostic model based on the hub RBPs by Cox regression and risk score analyses.Results: We found that the differentially expressed RBPs were closely related to the defence response to virus and multiple RNA processes. We obtained ten prognosis-related hub RBPs (ZC3H12D, OAS2, INTS10, ACO1, PCBP4, RNASE3, PTGES3L-AARSD1, RNASE13, DDX4, and PCF11) and effectively predicted the overall survival of OSCC patients. The area under the ROC curve (AUC) of the risk score model was 0.781, suggesting that our model had good prognostic performance. Finally, we built a nomogram integrating the ten RBPs. The internal validation cohort results showed a reliable predictive capability of the nomogram for OSCC.Conclusions: We established a novel ten-RBP-based model for OSCC that could enable precise therapeutic targets in the future.
EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses
Authors: Yan Yang , Du Xiaohui , Xia Shaoyou , Li Songyan , Teng Da , Hu Shidong , Wang Yufeng , Li Rong 
Published: July 2020

Abstract
Background

Eyes absent 4 (EYA4) is involved in various biological processes. The aim of this study was to investigate the expression of EYA4 and its prognostic value in colorectal cancer (CRC).
Methods

The mRNA level of EYA4 in diseased tissues and adjacent normal tissues of CRC patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The association between EYA4 expression and clinicopathological characteristics was analyzed by χ2 test. Kaplan-Meier analysis with log rank test was performed to evaluate the effects of EYA4 expression on overall survival of CRC patients. Cox regression model was applied for prognosis analysis in CRC.
Results

The mRNA level of EYA4 was significantly decreased in CRC tissues compared with that in the adjacent normal tissue (P < 0.01). And its expression was affected by DUKE stage (P = 0.034), differentiation (P = 0.027) and vascular invasion (P = 0.037). Survival curve showed that patients with low expression of EYA4 had a significantly shorter overall survival than those with high expression (log rank test, P = 0.008). Low expression of EYA4 (HR = 1.989, 95%CI = 1.090-3.62902, P = 0.025) was an independent biomarker for poor prognosis in CRC patients.
Conclusion

EYA4 expression is decreased in CRC patients and negatively correlated with aggressive tumor progression. EYA4 may be a potential prognostic biomarker for CRC.
Enhanced recovery after surgery nursing, a risk factor for stoma-related complications in patients with low rectal cancer
Authors: Shao Weiling , Wang Honggang , Chen Qun , Zhao Wen , Gu Yulian , Feng Guoqin 
Published: July 2020

Abstract
Background: This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy.Methods: LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing.Results: A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing was the only independent risk factor for SRCs in LRC patients (OR: 2.04, 95%CI: 1.31-3.12, P=0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life.Conclusions: ERAS nursing was a risk factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.
Thrombocytopenia in Pediatric Congenital Heart Diseases Patient with the Transcatheter Closure
Authors: Yang Lei , Guo Ying , Huang Meirong , Zhang Xu , Xu Xinyi , Gao Wei , Liu Tingliang 
Published: July 2020

Abstract
Background: Postoperative thrombocytopenia with congenital heart disease (CHD) after percutaneous transcatheter closure (PTC) has seldom been reported. We sought to investigate the treatments, severity and causes of postoperative thrombocytopenia among patients with CHD undergoing PTC.Methods: Six PTC patients undergoing postoperative thrombocytopenia in our department were included. Platelet count was measured at admission and daily after PTC at least for day 9.Results: Three patients had platelet counts below 30×10^9 /L while in the other two patients the counts were below 50×10^9 /L. All patients achieved a stable platelet count, ranging from 99×10^9 /L to 241×10^9 /L after day 9. The platelet counts recovered after being given intravenously the methylprednisolone (two patients), immunoglobulin (one patient) and platelet transfusions (two patients). During the whole course, the face and limbs of one patients were visible ecchymosis but no major bleeding events were recorded.Conclusion: In this report, the clinical outcome of our patients were satisfactory; they complaints regressed after above treatment.
The Effect of Distal Tibial Tuberosity High Tibial Osteotomy on Postoperative Patellar Height and Patellofemoral Joint Degeneration
Authors: Han Changxiao , Li Xia , Tian Xiangdong , Zhao Jiping , Zhou Liqun , Tan Yetong , Ma Sheng , Hu Yuanyi , Chen Handong , Huang Ye 
Published: July 2020

Abstract
Background: Distal tibial tuberosity high tibial osteotomy (DTT-HTO) can prevent distalization of the tibial tuberosity and thus patella infra. However, no studies on the clinical and radiological effects of DTT-HTO on the patellofemoral joint have been conducted. The purpose of the study was to evaluate the effect of DTT-HTO on patella height and patellofemoral joint congruity based on the severity of patellofemoral joint OA.Methods: Twenty-nine patients (33 knees) who underwent DTT-HTO and second-look arthroscopy when implant removal between January 2018 and May 2020 were eligible for the study. Among them, 6 were males, and 23 were females, with ages from 51-78 years old. The Caton-Deschamps index (CDI), congruence angle (CA) and lateral patellar tilt (LPT) were measured to evaluate the effect of surgery on patellar height and patellofemoral joint congruity. The weightbearing line ratio (WBLR) was measured to assess lower limb alignment. The cartilage lesion in the patellofemoral joint was assessed arthroscopically during surgery and implant removal by the International Cartilage Repair Society (ICRS) grading system at 18-24 months after surgery. The Hospital for Special Surgery scale (HSS) was used to evaluate knee joint function.Results: Twenty-nine patients were followed up for 18-28 months. The preoperative CDI, CA and LPT changed from 0.92±0.16 to 0.89±0.14, from 5.52±2.19 to 5.44±2.27 and from 6.95±2.88 to 6.54±2.42, respectively, and the differences were not statistically significant (p＞0.05). The preoperative WBLR significantly increased from 16.72±6.77% to 58.77±7.69% (p < 0.001). The cartilage lesions in the patella and femoral trochlea did not progress significantly from the first- to the second-look arthroscopy, according to the ICRS grades (p＞0.05). The HSS score significantly improved from 50.64±19.18 preoperatively to 67.33±14.72, 81.63±11.92 and 82.73±8.05 at the 3-month, 12-month, and last follow-up after surgery (p < 0.001).Conclusion: DTT-HTO can effectively prevent patellar infra, and its effects on postoperative patellofemoral joint congruity and patellofemoral joint OA progression are inconspicuous. It can be recommended as a treatment of varus knee combined with patella infra or patellofemoral joint OA.
A Predictive Formula for Difficult Endotracheal Intubation in the Emergency Department
Authors: Liao En-Chih , Chang Wen-Han , Yu Ching-Hsiang , Shen Cheng-Ying , Sun Fang-Ju , Lai Wen-Jyun , Chien Ding-Kuo 
Published: July 2020

Abstract
Background Current predictors for evaluating difficult endotracheal intubation had poor accessibility or sensitivity at the emergency department, so we evaluated the incidence and predictive factors, then built an easy-to-use predictive formula.Methods For the 110 patients, difficult airway was defined as Cormack & Lehane classification grade III and IV at first attempt of intubation. The univariate associations between patient characteristics and difficult endotracheal intubation were then analyzed, and the significantly associated factors were included in a multivariate binary logistic regression model then a predictive formula was generated. Generalized association plot (GAP) was used to show the relationship between each variables.Results The incidence of difficult intubation in our study was 35.5%. In the difficult airway group, significantly higher rates (p<0.05) of high body mass index (BMI); double chin; thick, short neck; Mallampati difficulty; smaller inter-incisors distance; smaller thyromental distance; and upper airway obstruction were noted. Finally, a predictive formula for difficult intubation was successfully established by the combination of four predictors: BMI (odds ratio [OR]=1.270), thyromental distance (OR=0.614), upper airway obstruction (OR=4.038), and Mallampati difficulty (OR=5.163). A cut-off score of 4 provided the best sensitivity (79.5%) and specificity (81.7%)(95% CI: 0.794 to 0.938).Conclusions Our predictive formula could be used by emergency physicians to quickly identify and carefully manage patients with potentially difficult intubation. Early expert consultation could be sought when necessary.Trial registration This 17-month (2011/11/1-2013/3/31) prospective observational study was approved by the Institutional Review Board of MacKay Memorial Hospital (11MMHISO64).
Keine «Rationierung» im geltenden KVG
Authors: Gächter Thomas 
Published: July 2020

Spätestens seit der viel diskutierten «Erwägung 7» des Myozyme-Entscheids von 2010 (BGE 136 V 395) stellte sich die Frage, ob im Rahmen des krankenversicherungsrechtlichen Wirtschaftlichkeitsgebots eine Obergrenze für die Kostenübernahme bestehe. Im Fall eines 71-jährigen Patienten, der aufgrund verschiedener Komplikationen Spitalkosten von über zwei Millionen Franken verursacht hatte, hat das Bundesgericht dies nun mit aller wünschbaren Klarheit verneint.
Influence mechanism of climate change over crop growth and water demands for wheat-rice system of Punjab, Pakistan
Authors: Ahmad Mirza Junaid , Cho Gun-Ho , Kim Sang-Hyun , Lee Seulgi , Adelodun Bashir , Choi Kyung-Sook 
Published: July 2020

Abstract
Conceptualizing the climate change perspective of crop growth and evapotranspiration (ETc) rates and subsequent irrigation water requirements (IWR) is necessary for sustaining the agriculture sector and tackling food security issues in Pakistan. This article projects the future growth periods and water demands for the wheat-rice system of Punjab. Intense and hotter transitions in the future thermal regimes and erratic monsoon rainfall increments were envisaged. The crop growth rates were accelerated by the probable temperature rise resulting in shortened growth periods. The temperature rise increased the reference evapotranspiration rates; however, the future ETc declined due to reduced growth period and net radiation. Highly unpredictable, but mostly increasing, cumulative seasonal and annual rainfalls were indicative of more effective rainfalls during the future crop seasons. Reduced ETc and increments in seasonal effective rainfalls gave rise to the declining IWR for both crops. The study findings seemingly undermined the harmful climate change influences on the water requirements of the wheat-rice system of Punjab but alarmingly shortening of growth periods indicates a higher crop failure tendency under the projected future thermal regime.
Assessing the contribution of biofilm to bacterial growth during stagnation in shower hoses
Authors: Peng Hongxi , Zhang Ya , Wang Ruowei , Liu Jingqing , Liu Wen-Tso 
Published: July 2020

Abstract
Stagnation occurs in building water supplies when there is little or no water usage. As a result, the number of bacteria increase, and this often leads to the deterioration of water quality. Still, the role of biofilm in stagnation remains unclear. This study used shower hoses as the model system and investigated the contribution of biofilm and microbes in fresh water to the bacterial growth in water under different stagnation times from 6 to 24 h. Bacterial counts in water were observed to increase significantly after 12 h stagnation but longer stagnation did not lead to further increase, indicating different mechanisms contributing to bacterial growth during stagnation. 16S rRNA gene sequencing and Sourcetracker2 further confirmed that the contribution of fresh water to the microbial core community did not increase significantly with stagnation time, whereas the contribution of biofilm increased significantly after 24 h stagnation (53.5%) compared with 6 h stagnation (11.2%) (p &lt; 0.05). The present results differentiated the contribution between planktonic and biofilm phase to the bacterial growth during stagnation, and provided insights into its mechanism. These findings serve as a framework for future development of strategies to manage biological water quality at the distal end of the building water supplies.
Instruments of Cognizing the Social and Economic Field of Society: Objectives, Challenges and Prospects
Authors: Tishkina N. P. , Rybina G. A. 
Published: July 2020

Today’s concepts, theories and methodology of classical political economy, economics in general, state and economic governance clearly demonstrate their unsoundness in resolving issues of rational organization of public reproduction by levels of economic management. They are characterized by the subjective-contract and dogmatic tool and the relevant theory of cognition, which are aimed at retaining the discriminative-degrading, religiouspolitical initial model of man and society vital functions in nature, i. e. ‘Tyrant – Victim’. Their alternative is the system-integrated inter-disciplinary methodology providing the development of scientific, objective economic theory, rational practice of state and economic governance of public production, which excludes political mongering, subjectivism and voluntarism. The current internal and external situation in Russia shows that neither traditional public sciences and their leading academics, nor state bodies and their advisers-scientists, nor politicians can produce a variant of further positive development of society and production for the near future. An additional set of notions, categories and tools of cognition supplementary to the traditional one was designed on the basis of approaches put forward by supporters of classical political-economic, biosphere, noosphere and fundamental sciences. It does not reject the accumulated experience, which can be adapted, concretize and correct to improve the quality of research in accordance with the extended totality of objective general, social and economic laws of man and society development in nature.
The Structure of Russian Large Business Demand for Innovation in the Contex of Corporate Accelerators
Authors: Popov A. N. 
Published: July 2020

The article studies the dynamics of the corporate accelerator model development in Russia from 2013 to 2020, the existing model of corporate acceleration and subsequent introduction of the start-up product in the corporation, as well as the structure of Russian corporations’ demand for innovation solutions of start-ups. The low level of Russian business digitalization in comparison with EU countries, dropping dynamics since 2013 of the specific weigh of innovation products and services in the total volume of sold products and services and the growing activity of corporations in the field of innovation in 2016–2019 stipulate a high potential of corporate innovation development in Russia. By studying 54 programs of corporate acceleration the author identified the key models of corporate accelerators’ organization in Russia and showed the growing dynamics of their development since 2018. For deeper investigation of the mechanism of start-ups and corporations interaction in the context of corporate accelerator through system analysis the article provides the model of organizing corporate accelerator and pilot launch of joint work of start-up and corporation on the basis of reports by spokesmen of Russian corporations at conferences and webinars. Based on open information about 72 innovation projects and experience of interaction of Russian corporations from telecommunications and finance fields the structure of corporations’ demand for highlytechnological solutions of start-ups was identified. Through classification methods the author described the demand in view of methods of technology introduction, the sphere of using technology in the corporation and key technologies applied in innovation solution of start-ups.