bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Impact of an Epidemic/Pandemic on the Mental Health of Healthcare Professionals: A Rapid Review
Authors: Stuijfzand Suzannah , Deforges Camille , Sandoz Vania , Sajin Consuela-Thais Consuela-Thais , Jaques Cécile , Elmers Jolanda , Horsch Antje 
Published: June 2020

Abstract
Background: Epidemics or pandemics, such as the current Coronavirus Disease 2019 (COVID-19) crisis, pose unique challenges to healthcare professionals (HCPs). Caring for patients during an epidemic/pandemic may impact negatively on the mental health of HCPs. There is a lack of evidence-based advice on what would be effective in mitigating this impact. Objectives: This rapid review synthesizes the evidence on the psychological impact of pandemics/epidemics on the mental health of HCPs, what factors predict this impact, and the evidence of prevention/intervention strategies to reduce this impact. Method: According to rapid review guidelines, systematic searches were carried out in Embase.com, PubMed, APA PsycINFO-Ovid SP, and Web of Science (core collection). Searches were restricted to the years 2003 or later to ensure inclusion of the most recent epidemic/pandemics, such as Severe Acute Respiratory Syndrome (SARS). Papers written in French or English, published in peer-reviewed journals, and of quantitative design using validated measures of mental health outcomes were included. Of 1308 papers found, 48 were included. The full protocol for this rapid review was registered with Prospero (reg.no.CRD42020175985). Results: Results show that exposed HCPs working with patients during an epidemic/pandemic are at heightened risk of mental health problems in the short and longer term, particularly: psychological distress, insomnia, alcohol/drug misuse, and symptoms of posttraumatic stress disorder (PTSD), depression, anxiety, burnout, anger, and higher perceived stress. These mental health problems are predicted by organizational, social, personal, and psychological factors and may interfere with the quality of patient care. Few evidence-based early interventions exist so far. Discussion: Several recommendations relevant during and after an epidemic/pandemic, such as COVID-19, and in preparation for a future outbreak, are proposed.
A Novel Technique of ECG Denoising based on Lifting Wavelet Transform and Total Variation Minimization
Authors: Mourad Talbi , Riadh Baazaoui 
Published: June 2020

Abstract
Buckground:The signal of Electrocardiogram (•) is one of the most popular diagnostic means providing an electrical picture of the heart and also information about different pathological conditions. Due to the path deformities and external electrical disturbances, the signal of becomes noisy. Hence, in literature, many ECG denoising algorithms have been proposed and among them we can mention the techniques based on wavelet coefficient shrinkage. The purpose of this paper is to denoise ECG signals applying a new ECG Denoising technique and proving its performance compared to some denoising approaches existing in literature. This new proposed technique of B Denoising consists at the first step in applying the Lifting Wavelet Transform (u) to the noisy c Signal (where 2 is the decomposition level) in order to obtain three noisy wavelet sub-bands, k, g and r. The two coefficients, o, u are details ones and they are denoised by soft or hard thresholding in order to obtain denoised coefficients, n1 and d2. The coefficient : is an approximation one and is denoised by Total Variation Minimization in order to obtain a denoised one, T2. Finally, the inverse of his applied to e, and s in order to obtain the denoised i signal. The evaluation of this proposed technique is performed by comparing it to three other denoising approaches existing in literature. The first one of these approaches is based on g, the second one is n double-density complex a denoising method and the third one is based on non local means.Results:All These techniques are applied on a number of lsignals taken from database and corrupted by an additive White Gaussian noise at different values of Signal to Noise Ratio (o). The obtained results from the computation of the f and the Mean Square Error ( ), show that the proposed technique outperforms the other three mentioned techniques.Conclusion:In this paper, the proposed ECG denoising technique based on E and l, outperforms the other previously mentioned denoising approaches and this based on the computation of the SNR and MSE.
Metallic Stent Placement Versus Catheter Drainage for Malignant Bilioenteric Anastomotic Stricture
Authors: Zhou Wei-zhong , Wu Jun-zheng , Liu Sheng , Wan Wei , Zhou Chun-gao , Shi Hai-Bin 
Published: June 2020

Abstract
Background
Currently, the percutaneous approach is the mainstream of treatment for malignant bilioenteric anastomotic stricture (BAS). However, there is no consensus on the optimal bile drainage method since previous studies on malignant BAS related jaundice are very limited. The purpose of the study is to compare self-expandable metallic stent placement with catheter drainage for malignant bilioenteric anastomotic stricture in terms of efficacy and safety.
Materials and Methods
This study included 54 patients with malignant bilioenteric anastomotic stricture treated from March 2016 to February 2020. Twenty-seven patients underwent insertion of self-expandable metallic stent (Stent group); the remaining twenty-seven patients underwent internal-external catheter drainage (Catheter group). Technical success was defined as successful placement of stent or drainage catheter in the appropriate position; clinical success was defined as a 20% reduction in serum bilirubin within 1 week after the procedure, compared with baseline. Complications, duration to stent/catheter malfunction, and overall survival were evaluated.
Results
Technical success was achieved in all patients in both groups. In the Stent group, 21 patients received one stent and the other 6 patients required two stents. Clinical success rates were similar between the groups (Stent group, 92.6% [25/27]; Control group, 88.9% [24/27]). There were no major complications. The median duration to stent/catheter malfunction was significantly longer in the Stent group (130 days) than in the Control group (82 days; P = 0.010). The median overall survival was also significantly longer in the Stent group (187 days) than in the Catheter group (118 days; P = 0.038).
Conclusion
Self-expandable metallic stent placement may be better than internal-external catheter drainage for malignant bilioenteric anastomotic stricture in terms of the duration before stent/catheter malfunction and patient survival.
Actin Reorganization in Hippocampal Neurons May Play Roles in Early Impairment of Learning and Memory in Rats After Propofol Anesthesia
Authors: Zhang Xuena , Li Jie , WU ANSHI 
Published: June 2020

Abstract
Background Perioperative neurocognitive disorder (PND) is a kind of neuronal complication especially observed in elderly patients. The present study was conducted to observe the changes of actin in hippocampus after propofol anesthesia, and to evaluate their roles in consequent learning impairment in both young (3-month-old) and aged (20-month-old) male rats.Methods Double-shuttle box was used to learning evaluation since1, 3, 7 or 14d after anesthesia. Hippocampi were removed after evaluations. F-actin content and the spines were observed through immunofluorescence and laser scanning confocal microscope (LSCM).Results In young rats, latency of escape response (LER) was prolonged within 3 days after anesthesia. However, LER was significantly prolonged until 7days after anesthesia in elderly rats. Moreover, the learning curves were also shift in old rats. Dendritic spines became smaller in anesthesia groups of aged rats within 3 days, where the F-actin contents were significantly increased until 14d post anesthesia.Conclusion Our results indicate that learning ability could be inhibited until after propofol anesthesia especially in old rats. The over-polymerization of actin and the consequent reorganization of dendrite spines in hippocampus may be responsible, which provides fresh evidence in aspect of synaptic plasticity for PND mechanism.
Predictions of Current and Future Episodic Memory Using Grey Matter Volume and Functional Connectome: A Longitudinal Study in Amnestic Mild Cognitive Impairment Patients
Authors: Wang Zan , Shu Hao , Liu Duan , Su Fan , Xie Chunming , Cui Zaixu , Zhang Zhijun 
Published: June 2020

Abstract
Background: Amnestic mild cognitive impairment (aMCI) patients are considered an at-risk group for progression to Alzheimer’s dementia and accurate prediction of aMCI progression could facilitate the optimal decision-making for both clinicians and patients. Based on the baseline whole-brain grey-matter volume (GMV) and resting-state functional connectivity (FC), we used relevance vector regression to predict the baseline and longitudinal Rey’s Auditory Verbal Learning Test Delayed Recall (AVLT-DR) scores of individual aMCI patients.Methods: Fifty aMCI patients completed baseline and 3-year follow-up visits. All patients underwent comprehensive neuropsychological assessments and multimodal brain MRI scans.Results: We found that the GMV pattern predicted the baseline AVLT-DR score, while the pattern of FC predicted the longitudinal AVLT-DR score. In particular, GMV predicted the baseline AVLT-DR score with an accuracy of r = 0.54 (P < 0.001); the regions that contributed the most were within the default mode (e.g., the posterior cingulate gyrus, angular gyrus and middle temporal gyrus) and limbic systems (e.g., the hippocampus and parahippocampal gyrus). The FC predicted the longitudinal AVLT-DR score with an accuracy of r = 0.50 (P < 0.001), and the connections that contributed the most were the within- and between-system connectivity of the default mode and limbic systems. As a complement, we demonstrated that the GMV and FC patterns could also effectively predict the baseline and longitudinal composite episodic memory scores (calculated by averaging three well-known episodic memory test scores).Conclusions: Our results demonstrated the multimodal brain features in the individualized prediction of aMCI patients’ current and future episodic memory performance. These “neural fingerprints” have the potential to be biomarkers for aMCI patients and can help medical professionals optimize individual patient management and longitudinal evaluation.
Modelling Health Belief Predictors of Oral Health and Dental Anxiety Among Adolescents Based on the Health Belief Model: A Cross-Sectional Study
Authors: Xiang Bilu , Wong Hai Ming , Perfecto Antonio P. , McGrath Colman P.J. 
Published: June 2020

Abstract
Background: A vicious cycle exists between dental anxiety, oral health behaviors and oral health status. Based on previous research, psychological factors of the Health Belief Model (HBM) are associated with oral health behaviors and oral health, and are likely involved in this cycle. However, little is known about the relationship between HBM factors and dental anxiety of adolescents. The purpose of this cross-sectional study was to investigate the relationship between health belief factors, oral health and dental anxiety based on the constructs of the HBM.Methods: 1207 Grade 2 students from 12 secondary schools in Hong Kong were randomly selected and measured for the decayed, missing and filled permanent teeth (DMFT) index. Data for oral health behaviors, HBM constructs and dental anxiety were collected using questionnaires. The hierarchical entry of explanatory variables into logistic regression models estimating prevalence odds ratios (POR) were analyzed and 95% confidence intervals (95% CI) for DMFT and dental anxiety were generated. Path analysis was used to evaluate the appropriateness of the HBM as predictors for oral health behaviors, DMFT and dental anxiety.Results: Based on the full model analysis, individuals with higher perceived susceptibility of oral diseases (POR: 1.33, 95% CI: 1.14-1.56) or girls or whose mother received higher education level were likelier to have a DMFT≥1, while those with higher perceived severity (POR: 1.31, 95%CI: 1.09-1.57), flossing weekly, DMFT≥1 or higher general anxiety level statistically increases the possibility of dental anxiety. The results from path analysis indicated that stronger perceived susceptibility, greater severity of oral diseases, less performing of oral health behaviors and a higher score of DMFT were directly related to increased dental anxiety level. Other HBM variables, such as perceived susceptibility, self-efficacy beliefs, cues to action and perceived barriers, might influence dental anxiety through oral health behaviors and caries status.Conclusions: Clarifying the propositional structures of the HBM can help the future design of cognitive-behavioral therapy in reducing dental anxiety and preventing dental caries.
Application of Data Mining Technology in Risk Prediction of Metabolic Syndrome in Oil Workers
Authors: Wang Jie , Li Chao , Li Jing , Qin Sheng , Liu Chunlei , Wang Jiaojiao , Chen Zhe , Wu Jianhui , Wang Guoli 
Published: June 2020

Abstract
Background. The prevalence of metabolic syndrome continues to rise sharply worldwide, seriously threatening people's health.In this paper, three kinds of risk prediction models applicable to the metabolic syndrome of oil workers were established, and the optimal models were found through comparison. The optimal model can be used to identify people at high risk of metabolic syndrome as early as possible, to predict their risk, and to persuade them to change their adverse lifestyle so as to slow down and reduce the incidence of metabolic syndrome.Methods. A total of 1,468 workers from an oil company who participated in occupational health physical examination from April 2017 to October 2018 were included in this study. We established the Logistic regression model, the random forest model and the convolutional neural network model, and compared the prediction performance of the models according to the F1 score, sensitivity, accuracy and other indicators of the three models.Results. The results showed that the accuracy of the three models in the training set was 83.45%, 94.21% and 86.34%, the sensitivity was 78.47%, 94.62% and 81.30%, the F1 score was 0.79, 0.93 and 0.83, and the area under the ROC curve was 0.894, 0.987 and 0.935, respectively. In the test set, the accuracy was 76.72%, 80.66% and 78.69%, the sensitivity was 70.00%, 77.50% and 68.33%, the F1 score was 0.70, 0.76 and 0.71, and the area under the ROC curve was 0.797, 0.861 and 0.855, respectively.Conclusions. The study showed that the prediction performance of random forest model is better than other models, and the model has higher application value, which can better predict the risk of metabolic syndrome in oil workers, and provide corresponding theoretical basis for the health management of oil workers.
Correlation of Adrenaline Doses With the Outcome of Paediatric Out-of-hospital Cardiac Arrest: Secondary Analysis of the SOS-KANTO 2012 Study
Authors: Ishihara Tadashi , Kondo Yutaka , Sueyoshi Koichiro , Matsuda Shigeru , Okamoto Ken , Tanaka Hiroshi 
Published: June 2020

Abstract
Background Out-of-hospital cardiac arrest (OHCA) is very rare in the paediatric population, with an annual incidence of 2-9 cases per 1,000,000 children. The predictive factors for survival included a shorter interval between the time of arrest and hospital arrival, a palpable pulse on presentation in the emergency department (ED), a shorter duration of resuscitation in the ED, and the administration of fewer doses of adrenaline in the ED. This study was conducted to evaluated the interrelationship between the paediatric OHCA outcome and the number of adrenaline doses administered during resuscitation. Methods The SOS-KANTO 2012 study had enrolled all OHCA patients who were transported to the participant hospitals by emergency medical service personnel. After screening the available data, we included paediatric OHCA patients (aged ≤ 18 years) in this study. The primary outcome was the return of spontaneous circulation (ROSC) and the number of adrenaline doses that were administered, and the secondary outcome was the neurological outcome at 1 month after the OHCA in relation to the number of adrenaline doses. Results Two hundred sixty-seven patients were included in the final analyses. During CPR, 62 and 205 paediatric patients did and did not achieve ROSC, respectively. Patients who survived to one month after the OHCA received fewer adrenaline doses than patients who died, although there was no significant intergroup difference (3 [1.75-5.25], vs. 4 [2.5-6], p=0.319). Patients with a good neurological outcome (PCPC 1-2) received fewer doses of adrenaline than those with an unfavourable neurological outcome (PCPC 3-6), but intergroup difference was not significant. Fewer doses of adrenaline were associated with an improved rate of successful ROSC (odds ration = 0.80,95% confidence interval = 0.69-0.92, p<0.01). Conclusion The present study reports associations of the neurological outcomes with adrenaline doses in paediatric patients with OHCA. More than three adrenaline doses were associated with poor neurological outcome, and a favourable outcome occurred infrequently. By using information that was only available up to 1 month after the OHCA, we found that a higher number of adrenaline doses was associated with poor neurological outcome.
Early Detection of Steroid-Induced Femoral Head Necrosis using 99mTc-Cys-Annexin V-based Apoptosis Imaging in a Rabbit Model
Authors: Wang Xiaolong , Li Jianbo , Man Da , Liu Rui , Zhao Jianmin 
Published: June 2020

Abstract
Background At present, the early diagnosis of femoral head necrosis mainly relies on MRI, and most early patients are difficult to make an accurate diagnosis. Therefore, to investigate the early diagnostic value of 99mTc-Cys-Annexin V SPECT imaging were compared with MRI in rabbit models of steroid-induced femoral head necrosis. Methods The rabbit models of steroid-induced femoral head necrosis were established by intravenous injection of horse serum and gluteal muscle injection of methylprednisolone in of 5-month-old healthy New Zealand white rabbits. 99mTc-Cys-Annexin V SPECT imaging and MRI were performed at 2nd week, 4th week, and 6th week after modeling. After that, histopathology was used to verify the success of modeling. Apoptosis was detected by transmission electron microscopy and TUNEL. Results At 2 weeks after the injection of hormone, 99mTc-Cys-Annexin V SPECT image showed abnormal radioactive uptake in the bilateral femoral head. And over time, the radioactivity concentration was more obvious, and the ratio of T/NT (target tissue/non-target tissues) was gradually increased. In the SPECT imaging at each time point, T/NT ratio of the model group was significantly higher than that of the control group (P < 0.01); at 4 weeks after the injection of hormone, MRI showed an abnormal signal of osteonecrosis. At 2, 4, and 6 weeks after hormone injection, apoptosis was observed by TUNEL and transmission electron microscopy. Conclusions 99mTc-Cys-Annexin V SPECT imaging can diagnose steroid-induced femoral head necrosis earlier than MRI, and has potential application value for non-invasively detecting early and even ultra-early stage of femoral head necrosis.
Differential genes and microbiota revealed by serum metabolomics of obese rats after intervention by Rhizoma Coptidis
Authors: zeng zhijun , Luo Kexing , Zhang Jiri Mutu , Ni Peng , Xiong Wangping , Luo Xiaoquan , Xu Guoliang , Liu Hongning , Ji Yanhua 
Published: June 2020

Abstract
Background

Integrating systems biology is an approach for investigating metabolic diseases in humans. However, few studies use this approach to investigate the mechanism by which Rhizoma Coptidis (RC) reduces the effect of glucose on high-fat induced obesity in rats.
Methods

Twenty-four specific pathogen-free (SPF) male Sprague-Dawley rats (80 ± 10 g) were used in this study. Serum metabolomics were detected by ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Liver tissue and cecum feces were used for RNA-Seq technology and 16S rRNA gene sequencing, respectively.
Results

We identified nine potential biomarkers, which are differential metabolites in the Control, Model and RC groups, including linoleic acid, eicosapentaenoic acid, arachidonic acid, stearic acid, and L-Alloisoleucine (p < 0.01). The liver tissue gene expression profile indicated the circadian rhythm pathway was significantly affected by RC (Q ≤ 0.05). A total of 149 and 39 operational taxonomic units (OTUs), which were highly associated with biochemical indicators and potential biomarkers in the cecum samples (FDR ≤ 0.05), respectively, were identified.
Conclusions

This work provides information to better understand the mechanism of the effect of RC intervention on the hypoglycemic effect in obese rats. The present study demonstrates that integrating systems biology may be a powerful tool to reveal the complexity of metabolic diseases in rats intervened by traditional Chinese medicine.
Changes of the F-Wave in the Acute Phase of Permanent Spinal Cord Ischaemic Injury Predict Spinal Cord Function in Animal Models of Rabbits
Authors: Zhou Yunfei , Liu Xingming , Heng Xueyuan , Zhang Jian , Song Qimin , Chen Chunmei 
Published: June 2020

Abstract
Background: To explore the changes of the F-wave in the posterior tibial nerve of rabbits after different levels of lumbar spinal cord ischaemic injury and its correlation with motor function and the extent of lumbar spinal cord pathological damage. Methods: Thirty New Zealand rabbits were randomly divided into 6 groups. The control group (n=5) was used to exclude the influence of anaesthesia and surgery on the F-wave. Different levels of lumbar arteries were ligated in the five experimental groups (n=5). The F-wave was recorded to observe the changes in the acute phase of spinal cord ischaemia.The correlation between the changes of the F-wave in the acute reversible phase and the motor function of the spinal cord was analysed. Results: The results for the control group indicated that anaesthesia and surgery did not affect the F-wave results.There was no statistically significant difference in the F-wave amplitudes and latency before and after ligation in the 1 and 2 level ligation groups. The F-wave changed immediately after ligation in the 3, 4 and 5 ligation groups. The latency of the F-wave gradually extended, the amplitude of the F-wave gradually reduced.The amplitude variations of the F-wave were positively correlated with the motor function 2 days after ligation, there was a statistically significant difference. Conclusion: The F-waves in the posterior tibial nerve of rabbits were found to be sensitive to the lumbar spinal cord ischaemic injury and specific to predict motor function.
High miR-93 Expression Predicts Good Prognosis in Acute Myeloid Leukemia
Authors: Liu Yan , Cheng Zhiheng , Cui Longzhen , Pang Yifan , Dai Yifeng , Fu Lin 
Published: June 2020

Abstract
Background: Overexpression of microRNA-93 (miR-93) predicted worse outcome in non-small cell lung cancer (NSCLC) and gastric cancer patients, yet the prognostic role of miR-93 in AML is still unclear.Methods: To further verify the prognostic significance of miR-93, the Cancer Genome Atlas database (TCGA) was screened and 161 AML patients with miR-93 expression information were included in our study.Results: Compared with the patients who received chemotherapy alone with lower miR-93 expression, those with higher miR-93 expression had significantly longer event-free survival (EFS) and overall survival (OS) (all P < 0.05). Moreover, the expression levels of miR-93 was no association with either EFS or OS in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Multivariate analysis confirmed that high miR-93 expression was an independent favorable factor for EFS and OS in AML patients only receiving chemotherapy (all P < 0.05).Conclusion: our study proved that high miR-93 expression could predict favorable prognosis in AML, but its prognostic effect could be overcome by allo-HSCT.