bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep model simulation of polar vortices in gas giant atmospheres
Authors: Garcia Ferran , Chambers Frank R N , Watts Anna L 
Published: September 2020

ABSTRACTThe Cassini and Juno probes have revealed large coherent cyclonic vortices in the polar regions of Saturn and Jupiter, a dramatic contrast from the east–west banded jet structure seen at lower latitudes. Debate has centred on whether the jets are shallow, or extend to greater depths in the planetary envelope. Recent experiments and observations have demonstrated the relevance of deep convection models to a successful explanation of jet structure, and cyclonic coherent vortices away from the polar regions have been simulated recently including an additional stratified shallow layer. Here we present new convective models able to produce long-lived polar vortices. Using simulation parameters relevant for giant planet atmospheres we find flow regimes of geostrophic turbulence (GT) in agreement with rotating convection theory. The formation of large-scale coherent structures occurs via 3D upscale energy transfers. Our simulations generate polar characteristics qualitatively similar to those seen by Juno and Cassini: They match the structure of cyclonic vortices seen on Jupiter; or can account for the existence of a strong polar vortex extending downwards to lower latitudes with a marked spiral morphology, and the hexagonal pattern seen on Saturn. Our findings indicate that these vortices can be generated deep in the planetary interior. A transition differentiating these two polar flows regimes is described, interpreted in terms of force balances and compared with shallow atmospheric models characterizing polar vortex dynamics in giant planets. In addition, heat transport properties are investigated, confirming recent scaling laws obtained with reduced models of GT.
The globular cluster M10: reassessment of stellar membership, distance, and age using its variable and HB stars
Authors: Arellano Ferro A , Yepez M A , Muneer S , Bustos Fierro I H , Schröder K P , Giridhar Sunetra , Calderón J H 
Published: September 2020

ABSTRACT
Time-series VI CCD photometry of the globular cluster M10 (NGC 6254) is employed to perform a detailed identification, inspection of their light curves, their classification, and their cluster membership, of all the known variables reported up to 2018. The membership analysis is based on the $Gaia$-DR2 positions and proper motions. The metallicity of the cluster is estimated based on the sole RRc star known in the cluster. The Fourier decomposition of its light curve leads to [Fe/H]$_{\rm ZW}$ = $-1.59 \pm 0.23$ dex. The mean cluster distance, estimated by several independent methods, is $5.0 \pm 0.3$ kpc. A multiapproach search in a region of about 10$\times$10 arcmin$^2$ around the cluster revealed three new variables, one SX Phe (V35) and two sinusoidal variables on the red giant branch (RGB) of unclear classification (V36 and V37). Modelling the HB stars is very sensitive to the stellar hydrogen shell mass, which surrounds the 0.50 $\mathrm{ M}_{\odot }$ helium core. To match the full stretch of the HB population, a range of total mass of 0.56–0.62 $\mathrm{ M}_{\odot }$ is required. These models support a distance of 5.35 kpc and an age of about 13 Gyr, and hint to some individual variation of the mass-loss on the upper RGB, perhaps caused by the presence of closed magnetic field in red giants.
Long tidal tails in merging galaxies and their implications
Authors: Ren Jian , Zheng X Z , Valls-Gabaud David , Duc Pierre-Alain , Bell Eric F , Pan Zhizheng , Qin Jianbo , Shi D D , Qiao Man , He Yongqiang , Wen Run 
Published: September 2020

ABSTRACT
We investigate the properties of long tidal tails using the largest to date sample of 461 merging galaxies with $\log (M_\ast /\rm M_\odot)\ge 9.5$ within 0.2 ≤ z ≤ 1 from the COSMOS survey in combination with Hubble Space Telescope imaging data. Long tidal tails can be briefly divided into three shape types: straight (41 per cent), curved (47 per cent), and plume (12 per cent). Their host galaxies are mostly at late stages of merging, although 31 per cent are galaxy pairs with projected separations d &gt; 20 kpc. The high formation rate of straight tidal tails needs to be understood as the projection of curved tidal tails accounts for only a small fraction of the straight tails. We identify 165 tidal dwarf galaxies (TDGs), yielding a TDG production rate of 0.36 per merger. Combined with a galaxy merger fraction and a TDG survival rate from the literature, we estimate that ∼5 per cent of local dwarf galaxies (DGs) are of tidal origin, suggesting the tidal formation is not an important formation channel for the DGs. About half of TDGs are located at the tip of their host tails. These TDGs have stellar masses in the range of $7.5\le \log (M_\ast /\rm M_\odot)\le 9.5$ and appear compact with half-light radii following the M*–Re relation of low-mass elliptical galaxies. However, their surface brightness profiles are generally flatter than those of local disc galaxies. Only 10 out of 165 TDGs have effective radii larger than 1.5 kpc and would qualify as unusually bright ultradiffuse galaxies.
Gene-Level, but Not Chromosome-Wide, Divergence between a Very Young House Fly Proto-Y Chromosome and Its Homologous Proto-X Chromosome
Authors: Son Jae Hak , Meisel Richard P 
Published: September 2020

AbstractX and Y chromosomes are usually derived from a pair of homologous autosomes, which then diverge from each other over time. Although Y-specific features have been characterized in sex chromosomes of various ages, the earliest stages of Y chromosome evolution remain elusive. In particular, we do not know whether early stages of Y chromosome evolution consist of changes to individual genes or happen via chromosome-scale divergence from the X. To address this question, we quantified divergence between young proto-X and proto-Y chromosomes in the house fly, Musca domestica. We compared proto-sex chromosome sequence and gene expression between genotypic (XY) and sex-reversed (XX) males. We find evidence for sequence divergence between genes on the proto-X and proto-Y, including five genes with mitochondrial functions. There is also an excess of genes with divergent expression between the proto-X and proto-Y, but the number of genes is small. This suggests that individual proto-Y genes, but not the entire proto-Y chromosome, have diverged from the proto-X. We identified one gene, encoding an axonemal dynein assembly factor (which functions in sperm motility), that has higher expression in XY males than XX males because of a disproportionate contribution of the proto-Y allele to gene expression. The upregulation of the proto-Y allele may be favored in males because of this gene’s function in spermatogenesis. The evolutionary divergence between proto-X and proto-Y copies of this gene, as well as the mitochondrial genes, is consistent with selection in males affecting the evolution of individual genes during early Y chromosome evolution.
Microchromosomes Exhibit Distinct Features of Vertebrate Chromosome Structure and Function with Underappreciated Ramifications for Genome Evolution
Authors: Perry Blair W , Schield Drew R , Adams Richard H , Castoe Todd A 
Published: September 2020

AbstractMicrochromosomes are common yet poorly understood components of many vertebrate genomes. Recent studies have revealed that microchromosomes contain a high density of genes and possess other distinct characteristics compared with macrochromosomes. Whether distinctive characteristics of microchromosomes extend to features of genome structure and organization, however, remains an open question. Here, we analyze Hi-C sequencing data from multiple vertebrate lineages and show that microchromosomes exhibit consistently high degrees of interchromosomal interaction (particularly with other microchromosomes), appear to be colocalized to a common central nuclear territory, and are comprised of a higher proportion of open chromatin than macrochromosomes. These findings highlight an unappreciated level of diversity in vertebrate genome structure and function, and raise important questions regarding the evolutionary origins and ramifications of microchromosomes and the genes that they house.
FACT and Ash1 promote long-range and bidirectional nucleosome eviction at the HO promoter
Authors: Yu Yaxin , Yarrington Robert M , Stillman David J 
Published: September 2020

AbstractThe Saccharomyces cerevisiae HO gene is a model regulatory system with complex transcriptional regulation. Budding yeast divide asymmetrically and HO is expressed only in mother cells where a nucleosome eviction cascade along the promoter during the cell cycle enables activation. HO expression in daughter cells is inhibited by high concentration of Ash1 in daughters. To understand how Ash1 represses transcription, we used a myo4 mutation which boosts Ash1 accumulation in both mothers and daughters and show that Ash1 inhibits promoter recruitment of SWI/SNF and Gcn5. We show Ash1 is also required for the efficient nucleosome repopulation that occurs after eviction, and the strongest effects of Ash1 are seen when Ash1 has been degraded and at promoter locations distant from where Ash1 bound. Additionally, we defined a specific nucleosome/nucleosome-depleted region structure that restricts HO activation to one of two paralogous DNA-binding factors. We also show that nucleosome eviction occurs bidirectionally over a large distance. Significantly, eviction of the more distant nucleosomes is dependent upon the FACT histone chaperone, and FACT is recruited to these regions when eviction is beginning. These last observations, along with ChIP experiments involving the SBF factor, suggest a long-distance loop transiently forms at the HO promoter.
Low-Profile Visualized Intraluminal Support Jr Braided Stent Versus Atlas Self-Expandable Stent for Treatment of Intracranial Aneurysms: A Single Center Experience
Authors: Monteiro Andre , Cortez Gustavo M , Aghaebrahim Amin , Sauvageau Eric , Hanel Ricardo A 
Published: September 2020

Abstract

BACKGROUND
The Neuroform Atlas Stent and Low-profile Visualized Intraluminal Support (LVIS) and LVIS Jr stents are used to treat intracranial aneurysms (IAs), but their safety, performance, and outcomes have not been directly compared.

OBJECTIVE
To compare the technical performance and outcomes of Atlas and LVIS Jr stents for treatment of IAs.

METHODS
IAs treated by stent-assisted coiling using an Atlas (Stryker, Kalamazoo, Michigan) or LVIS Jr (MicroVention, Aliso Viejo, California) device between January 2014 to November 2019 were retrospectively evaluated. Patient demographics, aneurysm size and location, technical difficulties, and clinical and angiographic follow-up were analyzed.

RESULTS
A total of 116 patients, (mean age 64.2 ± 11.8 yr, 72.7% female) with 121 aneurysms underwent stent-assisted coiling with deployment of Atlas (n = 64) or LVIS Jr (n = 57) stents. Mean aneurysm size was 6.2 ± 2.7 mm. Immediate rates of Raymond-Roy (RR) 1/2 were 89.0% (57/64) and 80.7% (46/57) for the Atlas and LVIS Jr groups, respectively. Neither group had major postoperative thromboembolic complications; however, 15.8% (9/57) of the LVIS Jr procedures had technical issues. Additionally, 88.5% (46/52) and 91.2% (33/36) of patients in the Atlas and LVIS Jr groups had RR 1/2 at a mean follow-up of 13.6 and 18.7 mo, respectively.

CONCLUSION
Treatment of IAs with Atlas and LVIS Jr stents results in favorable clinical outcomes and angiographic results at follow-up, with low rates of recurrence and retreatment, suggesting both devices are safe and effective. Notably, LVIS Jr had more technical problems than Atlas.
Predicting the Extent of Resection in Low-Grade Glioma by Using Intratumoral Tractography to Detect Eloquent Fascicles Within the Tumor
Authors: Mato David , Velasquez Carlos , Gómez Elsa , Marco de Lucas Enrique , Martino Juan 
Published: September 2020

Abstract

BACKGROUND
An early maximal safe surgical resection is the current treatment paradigm for low-grade glioma (LGG). Nevertheless, there are no reliable methods to accurately predict the axonal intratumoral eloquent areas and, consequently, to predict the extent of resection.

OBJECTIVE
To describe the functional predictive value of eloquent white matter tracts within the tumor by using a pre- and postoperative intratumoral diffusion tensor imaging (DTI) tractography protocol in patients with LGG.

METHODS
A preoperative intratumoral DTI-based tractography protocol, using the tumor segmented volume as the only seed region, was used to assess the tracts within the tumor boundaries in 22 consecutive patients with LGG. The reconstructed tracts were correlated with intraoperative electrical stimulation (IES)-based language and motor subcortical mapping findings and the extent of resection was assessed by tumor volumetrics.

RESULTS
Identification of intratumoral language and motor tracts significantly predicted eloquent areas within the tumor during the IES mapping: the positive predictive value for the pyramidal tract, the inferior fronto-occipital fasciculus, the arcuate fasciculus and the inferior longitudinal fasciculus positive was 100%, 100%, 33%, and 80%, respectively, whereas negative predictive value was 100% for all of them. The reconstruction of at least one of these tracts within the tumor was significantly associated with a lower extent of resection (67%) as opposed to the extent of resection in the cases with a negative intratumoral tractography (100%) (P < .0001).

CONCLUSION
Intratumoral DTI-based tractography is a simple and reliable method, useful in assessing glioma resectability based on the analysis of intratumoral eloquent areas associated with motor and language tracts within the tumor.
Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015
Authors: Kotkansalo Anna , Leinonen Ville , Korajoki Merja , Korhonen Katariina , Rinne Jaakko , Malmivaara Antti 
Published: September 2020

Abstract

BACKGROUND
Surgery for degenerative cervical spine disease has escalated since the 1990s. Fusion has become the mainstay of surgery despite concerns regarding adjacent segment degeneration. The patient-specific trends in reoperations have not been studied previously.

OBJECTIVE
To analyze the occurrence, risk factors, and trends in reoperations in a long-term follow-up of all the patients operated for degenerative cervical spine disease in Finland between 1999 and 2015.

METHODS
The patients were retrospectively identified from the Hospital Discharge Registry. Reoperations were traced individually; only reoperations occurring >365 d after the primary operation were included. Time trends in reoperations and the risk factors were analyzed by regression analysis.

RESULTS
Of the 19 377 identified patients, 9.2% underwent a late reoperation at a median of 3.6 yr after the primary operation. The annual risk of reoperation was 2.4% at 2 yr, 6.6% at 5 yr, 11.1% at 10 yr, and 14.2% at 15 yr. Seventy-five percent of the late reoperations occurred within 6.5 yr of the primary operation. Foraminal stenosis, the anterior cervical decompression and fusion (ACDF) technique, male gender, weak opiate use, and young age were the most important risk factors for reoperation. There was no increase in the risk of reoperations over the follow-up period.

CONCLUSION
The risk of reoperation was stable between 1999 and 2015. The reoperation risk was highest during the first 6 postoperative years and then declined. Patients with foraminal stenosis had the highest risk of reoperation, especially when ACDF was performed.
Impact of Frailty on Outcomes Following Spine Surgery: A Prospective Cohort Analysis of 668 Patients
Authors: Agarwal Nitin , Goldschmidt Ezequiel , Taylor Tavis , Roy Souvik , Dunn Stefanie C Altieri , Bilderback Andrew , Friedlander Robert M , Kanter Adam S , Okonkwo David O , Gerszten Peter C , Hamilton D Kojo , Hall Daniel E 
Published: September 2020

Abstract

BACKGROUND
With an aging population, elderly patients with multiple comorbidities are more frequently undergoing spine surgery and may be at increased risk for complications. Objective measurement of frailty may predict the incidence of postoperative adverse events.

OBJECTIVE
To investigate the associations between preoperative frailty and postoperative spine surgery outcomes including mortality, length of stay, readmission, surgical site infection, and venous thromboembolic disease.

METHODS
As part of a system-wide quality improvement initiative, frailty assessment was added to the routine assessment of patients considering spine surgery beginning in July 2016. Frailty was assessed with the Risk Analysis Index (RAI), and patients were categorized as nonfrail (RAI 0-29) or prefrail/frail (RAI ≥ 30). Comparisons between nonfrail and prefrail/frail patients were analyzed using Fisher's exact test for categorical data or by Wilcoxon rank sum tests for continuous data.

RESULTS
From August 2016 through September 2018, 668 patients (age of 59.5 ± 13.3 yr) had a preoperative RAI score recorded and underwent scheduled spine surgery. Prefrail and frail patients suffered comparatively higher rates of mortality at 90 d (1.9% vs 0.2%, P < .05) and 1 yr (5.1% vs 1.2%, P < .01) from the procedure date. They also had longer in-hospital length of stay (LOS) (3.9 d ± 3.6 vs 3.1 d ± 2.8, P < .001) and higher rates of 60 d (14.6% vs 8.2%, P < .05) and 90 d (15.8% vs 9.8%, P < .05) readmissions.

CONCLUSION
Preoperative frailty, as measured by the RAI, was associated with an increased risk of readmission and 90-d and 1-yr mortality following spine surgery. The RAI can be used to stratify spine patients and inform preoperative surgical decision making.
Acute Hepatitis B Infection After a Switch to Long-Acting Cabotegravir and Rilpivirine
Authors: Pintado Claire , Delaugerre Constance , Molina Jean-Michel 
Published: September 2020

Abstract
Maintenance antiretroviral therapy with combination of two injectable long-acting drugs, cabotegravir and rilpivirine, is a new strategy addressing the challenges of daily adherence to oral pills that has shown non-inferior efficacy to standard of care therapy in patients with suppressed HIV-infection. Patients co-infected with hepatitis B virus (HBV) are not eligible for this dual therapy since it has no activity against HBV, but this strategy should also be restricted to patients with anti-HBs antibodies since people with HIV are still at risk of HBV acquisition due to high risk behavior and since HBV vaccination does not always elicit anti-HBs antibodies, as highlighted in the case report below.
Political Cycles in Bank Lending to the Government
Authors: Koetter Michael , Popov Alexander 
Published: September 2020

AbstractWe study how political party turnover after German state elections affects banks’ lending to the regional government. We find that between 1992 and 2018, party turnover at the state level leads to a sharp and substantial increase in lending by local savings banks to their home-state government. This effect is accompanied by an equivalent reduction in private lending. A statistical association between political party turnover and government lending is absent for comparable cooperative banks that exhibit a similar regional organization and business model. Our results suggest that political frictions may interfere with government-owned banks’ local development objectives.
Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings From the Northern Finland Birth Cohort 1986
Authors: Ramsay Hugh , Surcel Heljä-Marja , Björnholm Lassi , Kerkelä Martta , Khandaker Golam M , Veijola Juha 
Published: September 2020

Abstract
Prenatal infection is associated with brain structural and functional abnormalities and may increase the risk for psychosis through a direct effect on neurodevelopment. Various infections may exert their effect through a proinflammatory immune response but studies of prenatal maternal inflammatory markers and offspring neurodevelopment are scarce. Using the longitudinal Northern Finland Birth Cohort 1986 study, we examined the associations of maternal prenatal C-reactive protein (CRP) levels with psychosis risk factors in adolescent offspring. CRP was measured in maternal sera collected in pregnancy. In offspring, school performance was measured at age 7 years, while school performance, psychotic experiences, and cannabis use were measured at age 16 years. We tested associations of CRP with offspring measures using regression analysis controlling for offspring sex, maternal education level, and prenatal maternal body mass index, smoking and alcohol use in pregnancy, place of birth, maternal psychiatric admission, paternal psychiatric admission, mothers age at birth, and gestational week of CRP sample. We also tested if adolescent cannabis use mediated the associations between maternal CRP and offspring outcomes. Controlling for covariates, maternal CRP was associated with academic performance at age 16 years (beta = .062, 95% CI = 0.036–0.088), but not with possible psychotic experiences at 16 years (odds ratio [OR] = 1.09, 95% CI = 0.96–1.24). Maternal CRP was also associated with adolescent cannabis use (OR = 1.24, 95% CI = 1.07–1.43). These findings suggest that prenatal inflammation may influence later mental illness risk by affecting neurodevelopment and also indirectly by increasing the risk of exposure to cannabis.
Distinguishing Oneself From Others: Spontaneous Perspective-Taking in First-Episode Schizophrenia and its relation to Mentalizing and Psychotic Symptoms
Authors: Simonsen Arndis , Mahnkeke Mia Ilsø , Fusaroli Riccardo , Wolf Thomas , Roepstorff Andreas , Michael John , Frith Chris D , Bliksted Vibeke 
Published: September 2020

AbstractCharacteristic symptoms of schizophrenia, such as thought broadcasting, verbal hallucinations, and delusions of being controlled, suggest a failure in distinguishing between oneself and others. In addition, patients frequently experience mentalizing deficits, which could be related to such a failure. Here we investigated the tendency to distinguish self and other with a visual perspective-taking task that measures to what extent individuals spontaneously take another’s perspective when having to process their own (altercentric intrusion) or vice versa (egocentric intrusion). This was done in 22 patients with first-episode schizophrenia and 23 matched healthy controls. We assessed whether patients displayed altered altercentric or egocentric intrusion and whether such alterations are related to mentalizing deficits—as measured with the Animated Triangles Task (ATT) and The Awareness of Social Inference Task (TASIT) —and/or specific psychotic symptoms, suggestive of problems with self-other distinction. The results showed that patients display similar egocentric intrusion and increased altercentric intrusion compared to controls. Degree of altercentric intrusion was associated with severity of delusions and hallucinations that have been tied to problems with self-other distinction but not with unrelated delusions and hallucinations or negative symptom severity. Higher altercentric intrusion was also associated with better TASIT performance in both patients and controls; suggesting that it may also be beneficial. In conclusion, patients display difficulties inhibiting representations of the other when having to process self-relevant information. A failure to control or distinguish the 2 representations could give rise to the experience that others have access to and control of your thoughts and actions.