bluuebunny/crossref_metadata_2025_split huggingface dataset:
DATE PALM AND DATE PALM INFLORESCENCES IN THE LATE URUK PERIOD (C.3300 B.C.): BOTANY AND ARCHAIC SCRIPT
Authors: Paszke Marcin Z. 
Published: December 2019

The earliest evidence suggesting the human utilisation of wild date palm fruits in the Near East is dated to the sixth and fifth millennia B.C. Despite the lack of archaeological data, it is commonly believed that at the end of the Late Uruk period (c.3300–3100 B.C.) the Sumerians established the first date palm plantations. Nevertheless, this belief has never been well-proven by any scientific data, which makes this issue open to debate. This article points to the images of the date palm known from the pictographic script from Uruk as an important source of botanical data—a concept which has never been discussed in the literature—and elaborates on the phenotypic traits of thePhoenix dactylifera L.discernible there. It aims to establish the level and condition of horticultural knowledge of the cultivators of the date palm tree in the late fourth millennium B.C.Many of the botanical traits found on the date palm pictographs are noteworthy, especially where the morphology of the crown, trunk, and root zone are concerned. Most importantly, the identification of pictographs representing date palm inflorescences prompts us to the conclusion that the Sumerians discovered the dioecious nature of thePhoenix dactylifera L., selecting the staminate inflorescences to pollinate female trees by at least c. 3300 B.C. The discovery of this method of artificial fertilization was a turning point in Mesopotamian agriculture since it enabled farmers to obtain a better crop while economizing on space and labour, constituting the beginning of the date palm plantations that are still such a feature of present-day Iraq.
Torturing science
Authors: O’Mara Shane , Schiemann John 
Published: December 2019

AbstractContrary to the claims of the Central Intelligence Agency (CIA) that its torture program was scientific, the program was not based on biology or any other science. Instead, the George W. Bush administration veneered the program’s justification with a patina of pseudoscience, ignoring the actual biology of torturing human brains. We reconstruct the Bush administration’s decision-making process to establish that the policy decision to use torture took place in the immediate aftermath of the 9/11 attacks without any investigation into its efficacy. We then present the pseudoscientific model of torture sold to the CIA, show why this ad hoc model amounted to pseudoscience, and then catalog what the actual science of torturing human brains—available in 2001—reveals about the practice. We conclude with a discussion of how a process incorporating countervailing evidence might prevent a policy going forward that is contrary to law, ethics, and evidence.
“Holy Ghost Tribe:” The Needles Revival and the Origins of Pentecostalism
Authors: Reidy Skyler 
Published: December 2019

AbstractIn 1899, a religious revival in Needles, California, included the first recorded instance of tongues-speech in California. The revival was begun by a white Holiness preacher and included a predominantly Native American, but ethnically mixed, congregation. The Mohave Indians at the heart of the Needles Revival had survived in the Southern California borderlands by crossing boundaries and building new communities in the shadow of the modernizing state. As they participated in the Needles Revival, Mohave believers and others combined this pattern of boundary crossing with the theology and praxis of the Holiness movement to develop a local manifestation of the emerging Pentecostal movement. During the early twentieth century, a series of revivals around the world and a network of Holiness groups and missionaries developed into modern Pentecostalism. The most prominent of these revivals took place on Azusa Street in Los Angeles and emphasized speaking in tongues and multiracial community, not unlike the earlier revival in Needles. Taken together, these two revivals show the influence of Southern California on early Pentecostalism. Speaking in tongues enabled early Pentecostals to cross boundaries imposed by California's racial hierarchy, and the multiethnic communities they formed were a testament to the cultural dynamism of the region. As Mohave converts embraced Pentecostalism and eventually assumed leadership of the Needles congregation, they brought their legacy of survival and adaptation to the movement. In the process, they helped to shape modern Pentecostalism.
Public Opinion and Decisions About Military Force in Democracies
Authors: Tomz Michael , Weeks Jessica L.P. , Yarhi-Milo Keren 
Published: December 2019

AbstractMany theories of international relations assume that public opinion exerts a powerful effect on foreign policy in democracies. Previous research, based on observational data, has reached conflicting conclusions about this foundational assumption. We use experiments to examine two mechanisms—responsiveness and selection—through which opinion could shape decisions about the use of military force. We tested responsiveness by asking members of the Israeli parliament to consider a crisis in which we randomized information about public opinion. Parliamentarians were more willing to use military force when the public was in favor and believed that contravening public opinion would entail heavy political costs. We tested selection by asking citizens in Israel and the US to evaluate parties/candidates, which varied randomly on many dimensions. In both countries, security policy proved as electorally significant as economic and religious policy, and far more consequential than nonpolicy considerations such as gender, race, and experience. Overall, our experiments in two important democracies imply that citizens can affect policy by incentivizing incumbents and shaping who gets elected.
Just War and Unjust Soldiers: American Public Opinion on the Moral Equality of Combatants
Authors: Sagan Scott D. , Valentino Benjamin A. 
Published: December 2019

AbstractTraditional just war doctrine holds that political leaders are morally responsible for the decision to initiate war, while individual soldiers should be judged solely by their conduct in war. According to this view, soldiers fighting in an unjust war of aggression and soldiers on the opposing side seeking to defend their country are morally equal as long as each obeys the rules of combat. Revisionist scholars, however, maintain that soldiers who fight for an unjust cause bear at least some responsibility for advancing an immoral end, even if they otherwise fight ethically. This article examines the attitudes of the American public regarding the moral equality of combatants. Utilizing an original survey experiment, we find that the public's moral reasoning is generally more consistent with that of the revisionists than with traditional just war theory. Americans in our study judged soldiers who participate in unjust wars as less ethical than soldiers in just wars, even when their battlefield conduct is identical, and a large proportion supported harsh punishments for soldiers simply for participating in unjust wars. We also find, however, that much of the American public is willing to extend the moral license of just cause significantly further than revisionist scholars advocate: half of the Americans in our survey were willing to allow an unambiguous war crime—a massacre of innocent women and children—to go unpunished when the act was committed by soldiers fighting for a just cause. Our findings suggest that incorporation of revisionist principles into the laws of war would reinforce dangerous moral intuitions encouraging the killing of civilians.
Seed quality in rice is most sensitive to drought and high temperature in early seed development
Authors: Abdul Rahman Siti M. , Ellis Richard H. 
Published: December 2019

AbstractDrought and high temperature each damage rice (Oryza sativaL.) crops. Their effect during seed development and maturation on subsequent seed quality development was investigated in Japonica (cv. Gleva) and Indica (cv. Aeron 1) plants grown in controlled environments subjected to drought (irrigation ended) and/or brief high temperature (HT; 3 days at 40/30°C). Ending irrigation early in cv. Gleva (7 or 14 days after anthesis, DAA) resulted in earlier plant senescence, more rapid decline in seed moisture content, more rapid seed quality development initially, but substantial decline laterin plantain the ability of seeds to germinate normally. Subsequent seed storage longevity amongst later harvests was greatest with no drought because with drought it declined from 16 or 22 DAA onwardsin planta, 9 or 8 days after irrigation ended, respectively. Later drought (14 or 28 DAA) also reduced seed longevity at harvest maturity (42 DAA). Well-irrigated plants provided poorer longevity the earlier during seed development they were exposed to HT (greatest at anthesis and histodifferentiation; no effect during seed maturation). Combining drought and HT damaged seed quality more than each stress alone, and more so in the Japonica cv. Gleva than the Indica cv. Aeron 1. Overall, the earlier plant drought occurred the greater the damage to subsequent seed quality; seed quality was most vulnerable to damage from plant drought and HT at anthesis and histodifferentiation; and seed quality of the Indica rice was more resilient to damage from these stresses than the Japonica.
Post-operative blood loss is higher among African American neonates undergoing open-heart surgery with cardiopulmonary bypass for CHD
Authors: Kartha Vyas M. , Rehman Mohamed , Nguyen Anh Thy H. , Amankwah Ernest , Sibinga Erica M.S. , Goldenberg Neil A. , Jacobs Jeffrey P. 
Published: December 2019

AbstractBackground:Neonates are at high risk of bleeding after open-heart surgery. We sought to determine pre-operative and intra-operative risk factors for increased bleeding after neonatal open-heart surgery with cardiopulmonary bypass.Methods:We conducted a retrospective cohort study of neonates (0–30 days old) who underwent open-heart surgery with cardiopulmonary bypass from January, 2009, to March, 2013. Cardiac diagnosis; demographic and surgical data; and blood products, haemostatic agents, and anti-thrombotic agents administered before, during, and within 24 hours after surgery were abstracted from the electronic health record and anaesthesia records. The outcome of interest was chest tube output (in ml/kg body weight) within 24 hours. Relationships between chest tube output and putative associated factors were evaluated by unadjusted and adjusted linear regression.Results:The cohort consisted of 107 neonates, of whom 79% had a Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) Mortality Category of 4 or 5. Median chest tube output was 37 ml/kg (range 9–655 ml/kg). Age, African-American race, and longer durations of surgery and cardiopulmonary bypass each had statistically significant associations with increased chest tube output in unadjusted analyses. In multivariable analysis, African-American race retained an independent, statistically significant association with increased chest tube output; the geometric mean of chest tube output among African-American neonates was 71% higher than that of Caucasians (95% confidence interval, 29–125%; p = 0.001).Conclusion:Among neonates with CHD undergoing open-heart surgery with cardiopulmonary bypass, African-American race is independently associated with greater chest tube output over the first 24 hours post-operatively.
NAM population – a novel genetic resource for soybean improvement: development and characterization for yield and attributing traits
Authors: Maranna Shivakumar , Kumawat Giriraj , Nataraj Vennampally , Gireesh C. , Gupta Sanjay , Satpute Gyanesh K. , Ratnaparkhe Milind B. , Yadav Devendra P. 
Published: December 2019

AbstractNested association mapping (NAM) captures the best features of both linkage and association mapping and enables the high power and high resolution of quantitative trait locus mapping through joint linkage-association analysis. In the current study, NAM population was developed by hybridizing JS 335, a popular variety of central India with 20 diverse soybean genotypes. The parents used in the study have various traits of economic importance such as drought and water-logging tolerance, bacterial pustule and yellow mosaic virus resistance, wider adaptability, resistance to mechanical damage and higher yield potential. High variability in the F2populations of 20 crosses for grain yield and days to maturity indicated scope for development of high-yielding varieties. Genetic variability studies, correlation, regression, principal component analysis (PCA) and genetic diversity analyses were carried out in 900 NAM-recombinant inbred lines (RILs) derived from 11 crosses. Correlation and regression analysis indicated a significant positive effect of biomass, pods/plant, harvest index, branches/plant, nodes/plant and plant height on grain yield. Genetic diversity analysis grouped 900 NAM-RILs into 10 clusters. PCA revealed first two principal components to explain 63.78% of total variation mostly contributed by grain yield, biomass and number of pods. The inbred lines developed in this study will serve as an elite soybean genetic resource in understanding the genetic architecture underlying different traits of economic significance.
Correlation between obesity and manual lymphatic drainage in Germany	– a retrospective analysis from 2008 to 2016
Authors: Kröger Knut , Schulz Tino , Santosa Frans , von Beckerath Olga , Gäbel Gabor , Juntermanns Benjamin 
Published: December 2019

Summary: Backgrounds: Costs for manual lymphatic drainage (MLD) paid by the Statutory Health Insurances (SHI) have increased disproportionately in Germany in the last decade. There is no obvious reason that this increase is due to an increasing number of patients with lymph edema. We therefore assume that there are large numbers of patients with obesity and obesity-associated dependency syndrome who drive the cost of MLD and did a retrospective analysis of the correlation between hospitalization rates for lymph edema and obesity and MLD prescription rates in outpatients. Patients and methods: Roughly 90 % of the German population is insured by the Statutory Health Insurance. From its reports we extracted data regarding costs and numbers of MLD session prescribed annually. Hospitalization rates for lymph edema (codes I89.*, I97.2 and Q82.0) and for obesity (ICD E66.*) were provided by the Federal Statistical Office after a specific remote analyses. Results: In the years 2008 to 2016, the MLD prescriptions in the individual federal states increased by + 43.5 % in Berlin to + 109.3 % in Mecklenburg-Western Pomerania. Number of hospitalizations with the principal diagnosis (condition, which caused the admission) hereditary and postmastectomy lymph edema are low and decreased in most federal states. Number of hospitalizations with the additional diagnosis (conditions that coexist at the time of admission or develop subsequently) obesity increased with a range from + 4.8 % in Baden-Württemberg to + 86.4 % in Mecklenburg-Western Pomerania. The correlation between the increase in prescribed MLD in the individual federal state and the increase in hospitalization rates per 1000 inhabitants of cases with obesity is greater (R2 0.4696) than with lymph edema (R2 0.0987). Conclusions: Our analysis is in line with the hypothesis that there is a correlation between the increasing prescription rate of MLD and the increasing burden of obesity in Germany.
Aerosols in the E3SM Version 1: New Developments and Their Impacts on Radiative Forcing
Authors: Wang Hailong , Easter Richard C. , Zhang Rudong , Ma Po‐Lun , Singh Balwinder , Zhang Kai , Ganguly Dilip , Rasch Philip J. , Burrows Susannah M. , Ghan Steven J. , Lou Sijia , Qian Yun , Yang Yang , Feng Yan , Flanner Mark , Leung L. Ruby , Liu Xiaohong , Shrivastava Manish , Sun Jian , Tang Qi , Xie Shaocheng , Yoon Jin‐Ho 
Published: December 2019

AbstractThe new Energy Exascale Earth System Model Version 1 (E3SMv1) developed for the U.S. Department of Energy has significant new treatments of aerosols and light‐absorbing snow impurities as well as their interactions with clouds and radiation. This study describes seven sets of new aerosol‐related treatments (involving emissions, new particle formation, aerosol transport, wet scavenging and resuspension, and snow radiative transfer) and examines how they affect global aerosols and radiative forcing in E3SMv1. Altogether, they give a reduced total aerosol radiative forcing (−1.6 W/m2) and sensitivity in cloud liquid water to aerosols, but an increased sensitivity in cloud droplet size to aerosols. A new approach for H2SO4 production and loss largely reduces a low bias in small particles concentrations and leads to substantial increases in cloud condensation nuclei concentrations and cloud radiative cooling. Emitting secondary organic aerosol precursor gases from elevated sources increases the column burden of secondary organic aerosol, contributing substantially to global clear‐sky aerosol radiative cooling (−0.15 out of −0.5 W/m2). A new treatment of aerosol resuspension from evaporating precipitation, developed to remedy two shortcomings of the original treatment, produces a modest reduction in aerosols and cloud droplets; its impact depends strongly on the model physics and is much stronger in E3SM Version 0. New treatments of the mixing state and optical properties of snow impurities and snow grains introduce a positive present‐day shortwave radiative forcing (0.26 W/m2), but changes in aerosol transport and wet removal processes also affect the concentration and radiative forcing of light‐absorbing impurities in snow/ice.
XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion
Authors: Xu Jiheng , Hua Xiaohui , Yang Rui , Jin Honglei , Li Jingxia , Zhu Junlan , Tian Zhongxian , Huang Maowen , Jiang Guosong , Huang Haishan , Huang Chuanshu 
Published: December 2019

AbstractXIAP has generally been thought to function in bladder cancer. However, the potential function of structure-based function of XIAP in human BC invasion has not been well explored before. We show here that ectopic expression of the BIR domains of XIAP specifically resulted in MMP2 activation and cell invasion in XIAP-deleted BC cells, while Src was further defined as an XIAP downstream negative regulator for MMP2 activation and BC cell invasion. The inhibition of Src expression by the BIR domains was caused by attenuation of Src protein translation upon miR-203 upregulation; which was resulted from direct interaction of BIR2 and BIR3 with E2F1 and Sp1, respectively. The interaction of BIR2/BIR3 with E2F1/Sp1 unexpectedly occurred, which could be blocked by serum-induced XIAP translocation. Taken together, our studies, for the first time revealed that: (1) BIR2 and BIR3 domains of XIAP play their role in cancer cell invasion without affecting cell migration by specific activation of MMP2 in human BC cells; (2) by BIR2 interacting with E2F1 and BIR3 interacting with Sp1, XIAP initiates E2F1/Sp1 positive feedback loop-dependent transcription of miR-203, which in turn inhibits Src protein translation, further leading to MMP2-cleaved activation; (3) XIAP interaction with E2F1 and Sp1 is observed in the nucleus. Our findings provide novel insights into understanding the specific function of BIR2 and BIR3 of XIAP in BC invasion, which will be highly significant for the design/synthesis of new BIR2/BIR3-based compounds for invasive BC treatment.
RETRACTED ARTICLE: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway
Authors: Zhang Rui , Lin Hao-Ming , Broering Ruth , Shi Xiang-de , Yu Xian-huan , Xu Lei-bo , Wu Wen-rui , Liu Chao 
Published: December 2019

AbstractDysregulation of dickkopf-related protein 1 (DKK1) expression has been reported in a variety of human cancers. We previously reported that DKK1 was upregulated in hepatocellular carcinoma (HCC). However, the role of DKK1 in HCC remains unclear. This study aimed to investigate the clinical significance and biological functions of DKK1 in HCC. The expression of DKK1 was examined in cirrhotic and HCC tissues by immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR). DKK1 was silenced or overexpressed in HCC cell lines, and in vitro and in vivo studies were performed. Immunohistochemistry revealed that DKK1 was weakly expressed in cirrhotic tissues (8/22, 36.4%) but upregulated in HCC tissues (48/53, 90.6%, cohort 1). Significant upregulation of DKK1 was observed in 57.6% (19/33, cohort 2) of HCC tissues by qRT-PCR, and the expression of DKK1 was associated with tumor size (P = 0.024) and tumor number (P = 0.019). Genetic depletion of DKK1 impaired the proliferation, colony-forming ability, invasion, and tumor formation of HCC cells (HepG2 and HUH-7). Conversely, forced expression of DKK1 increased the proliferation, colony-forming ability, and invasion of HepG2 and HUH-7 cells in vitro and enhanced tumor formation in vivo. Subsequent investigation revealed that the DKK1-mediated proliferation and tumorigenicity of HepG2 and HUH-7 cells is dependent on the Wnt/β-catenin signaling pathway. These findings indicate that DKK1 plays an oncogenic role in HCC by activating the Wnt/β-catenin signaling pathway.
Features of non-activation dendritic state and immune deficiency in blastic plasmacytoid dendritic cell neoplasm (BPDCN)
Authors: Beird Hannah C. , Khan Maliha , Wang Feng , Alfayez Mansour , Cai Tianyu , Zhao Li , Khoury Joseph , Futreal P. Andrew , Konopleva Marina , Pemmaraju Naveen 
Published: December 2019

AbstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, male-predominant hematologic malignancy with poor outcomes and with just one recently approved agent (tagraxofusp). It is characterized by the abnormal proliferation of precursor plasmacytoid dendritic cells (pDCs) with morphologic and molecular similarities to acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)/chronic myelomonocytic leukemia (CMML) in its presentation within the bone marrow and peripheral blood. To identify disease-specific molecular features of BPDCN, we profiled the bone marrow, peripheral blood, and serum samples from primary patient samples using an in-house hematologic malignancy panel (“T300” panel), transcriptome microarray, and serum multiplex immunoassays. TET2 mutations (5/8, 63%) were the most prevalent in our cohort. Using the transcriptome microarray, genes specific to pDCs (LAMP5, CCDC50) were more highly expressed in BPDCN than in AML specimens. Finally, the serum cytokine profile analysis showed significantly elevated levels of eosinophil chemoattractants eotaxin and RANTES in BPDCN as compared with AML. Along with the high levels of PTPRS and dendritic nature of the tumor cells, these findings suggest a possible pre-inflammatory context of this disease, in which BPDCN features nonactivated pDCs.