bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite groups with weakly m-σ-permutable subgroups
Authors: Hussain Muhammad Tanveer , Amjid Venus 
Published: January 2020

Let [Formula: see text] be a finite group, [Formula: see text] be a partition of the set of all primes [Formula: see text] and [Formula: see text]. A set [Formula: see text] of subgroups of [Formula: see text] is said to be a complete Hall[Formula: see text]-set of [Formula: see text] if every non-identity member of [Formula: see text] is a Hall [Formula: see text]-subgroup of [Formula: see text] and [Formula: see text] contains exactly one Hall [Formula: see text]-subgroup of [Formula: see text] for every [Formula: see text]. A subgroup [Formula: see text] of [Formula: see text] is said to be [Formula: see text]-permutable in [Formula: see text] if [Formula: see text] possesses a complete Hall [Formula: see text]-set [Formula: see text] such that [Formula: see text] for all [Formula: see text] and all [Formula: see text]. Let [Formula: see text] be a subgroup of [Formula: see text]. [Formula: see text] is: [Formula: see text]-[Formula: see text]-permutable in [Formula: see text] if [Formula: see text] for some modular subgroup [Formula: see text] and [Formula: see text]-permutable subgroup [Formula: see text] of [Formula: see text]; weakly[Formula: see text]-[Formula: see text]-permutable in [Formula: see text] if there are an [Formula: see text]-[Formula: see text]-permutable subgroup [Formula: see text] and a [Formula: see text]-subnormal subgroup [Formula: see text] of [Formula: see text] such that [Formula: see text] and [Formula: see text]. In this paper, we investigate the influence of weakly [Formula: see text]-[Formula: see text]-permutable subgroups on the structure of finite groups.
Manipulations of inhibition in cortical circuitry differentially affect spectral and temporal features of Bengalese finch song
Authors: Isola Gaurav R. , Vochin Anca , Sakata Jon T. 
Published: January 2020

The interplay between inhibition and excitation can regulate behavioral expression and control, including the expression of communicative behaviors like birdsong. Computational models postulate varying degrees to which inhibition within vocal motor circuitry influences birdsong, but few studies have tested these models by manipulating inhibition. Here we enhanced and attenuated inhibition in the cortical nucleus HVC (used as proper name) of Bengalese finches ( Lonchura striata var. domestica). Enhancement of inhibition (with muscimol) in HVC dose-dependently reduced the amount of song produced. Infusions of higher concentrations of muscimol caused some birds to produce spectrally degraded songs, whereas infusions of lower doses of muscimol led to the production of relatively normal (nondegraded) songs. However, the spectral and temporal structures of these nondegraded songs were significantly different from songs produced under control conditions. In particular, muscimol infusions decreased the frequency and amplitude of syllables, increased various measures of acoustic entropy, and increased the variability of syllable structure. Muscimol also increased sequence durations and the variability of syllable timing and syllable sequencing. Attenuation of inhibition (with bicuculline) in HVC led to changes to song distinct from and often opposite to enhancing inhibition. For example, in contrast to muscimol, bicuculline infusions increased syllable amplitude, frequency, and duration and decreased the variability of acoustic features. However, like muscimol, bicuculline increased the variability of syllable sequencing. These data highlight the importance of inhibition to the production of stereotyped vocalizations and demonstrate that changes to neural dynamics within cortical circuitry can differentially affect spectral and temporal features of song.NEW & NOTEWORTHY We reveal that manipulations of inhibition in the cortical nucleus HVC affect the structure, timing, and sequencing of syllables in Bengalese finch song. Enhancing and blocking inhibition led to opposite changes to the acoustic structure and timing of vocalizations, but both caused similar changes to vocal sequencing. These data provide support for computational models of song control but also motivate refinement of existing models to account for differential effects on syllable structure, timing, and sequencing.
A Chimeric Signal Peptide–Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell–Specific Apoptosis
Authors: Lee Sok-Hyong , Khwaja Rehman Fatima , Tyler Kari C. , Yu Bing , Zhang Zhaobin , Osuka Satoru , Zerrouqi Abdessamad , Kaluzova Milota , Hadjipanayis Costas G. , Cummings Richard D. , Olson Jeffrey J. , Devi Narra S. , Van Meir Erwin G. 
Published: January 2020

Abstract

Purpose:
Exploitation of altered glycosylation in cancer is a major goal for the design of new cancer therapy. Here, we designed a novel secreted chimeric signal peptide–Galectin-3 conjugate (sGal-3) and investigated its ability to induce cancer-specific cell death by targeting aberrantly N-glycosylated cell surface receptors on cancer cells.

Experimental Design:
sGal-3 was genetically engineered from Gal-3 by extending its N-terminus with a noncleavable signal peptide from tissue plasminogen activator. sGal-3 killing ability was tested on normal and tumor cells in vitro and its antitumor activity was evaluated in subcutaneous lung cancer and orthotopic malignant glioma models. The mechanism of killing was investigated through assays detecting sGal-3 interaction with specific glycans on the surface of tumor cells and the elicited downstream proapoptotic signaling.

Results:
We found sGal-3 preferentially binds to β1 integrin on the surface of tumor cells due to aberrant N-glycosylation resulting from cancer-associated upregulation of several glycosyltransferases. This interaction induces potent cancer-specific death by triggering an oncoglycan-β1/calpain/caspase-9 proapoptotic signaling cascade. sGal-3 could reduce the growth of subcutaneous lung cancers and malignant gliomas in brain, leading to increased animal survival.

Conclusions:
We demonstrate that sGal-3 kills aberrantly glycosylated tumor cells and antagonizes tumor growth through a novel integrin β1–dependent cell-extrinsic apoptotic pathway. These findings provide proof-of-principle that aberrant N-oncoglycans represent valid cancer targets and support further translation of the chimeric sGal-3 peptide conjugate for cancer therapy.
Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non–Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy
Authors: Frick Melissa A. , Feigenberg Steven J. , Jean-Baptiste Samuel R. , Aguarin Louise A. , Mendes Amberly , Chinniah Chimbu , Swisher-McClure Sam , Berman Abigail , Levin William , Cengel Keith A. , Hahn Stephen M. , Dorsey Jay F. , Simone Charles B. , Kao Gary D. 
Published: January 2020

Abstract

Purpose:
Although stereotactic body radiotherapy (SBRT) is effective in early-stage non–small cell lung cancer (NSCLC), approximately 10%–15% of patients will fail regionally and 20%–25% distantly. We evaluate a novel circulating tumor cell (CTC) assay as a prognostic marker for increased risk of recurrence following SBRT.

Experimental Design:
Ninety-two subjects (median age, 71 years) with T1a (64%), T1b (23%), or T2a (13%) stage I NSCLC treated with SBRT were prospectively enrolled. CTCs were enumerated by utilizing a GFP-expressing adenoviral probe that detects elevated telomerase activity in cancer cells. Samples were obtained before, during, and serially up to 24 months after treatment. SBRT was delivered to a median dose of 50 Gy (range, 40–60 Gy), mostly commonly in four to five fractions (92%).

Results:
Thirty-eight of 92 subjects (41%) had a positive CTC test prior to SBRT. A cutoff of ≥5 CTCs/mL before treatment defined favorable (n = 78) and unfavorable (n = 14) prognostic groups. Increased risk of nodal (P = 0.04) and distant (P = 0.03) failure was observed in the unfavorable group. Within 3 months following SBRT, CTCs continued to be detected in 10 of 35 (29%) subjects. Persistent detection of CTCs was associated with increased risk of distant failure (P = 0.04) and trended toward increased regional (P = 0.08) and local failure (P = 0.16).

Conclusions:
Higher pretreatment CTCs and persistence of CTCs posttreatment is significantly associated with increased risk of recurrence outside the targeted treatment site. This suggests that CTC analysis may potentially identify patients at higher risk for regional or distant recurrences and who may benefit from either systemic therapy and/or timely locoregional salvage treatment.
PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma
Authors: Ganci Federica , Pulito Claudio , Valsoni Sara , Sacconi Andrea , Turco Chiara , Vahabi Mahrou , Manciocco Valentina , Mazza Emilia Maria Cristina , Meens Jalna , Karamboulas Christina , Nichols Anthony C. , Covello Renato , Pellini Raul , Spriano Giuseppe , Sanguineti Giuseppe , Muti Paola , Bicciato Silvio , Ailles Laurie , Strano Sabrina , Fontemaggi Giulia , Blandino Giovanni 
Published: January 2020

Abstract

Purpose:
Mutation of TP53 gene is a hallmark of head and neck squamous cell carcinoma (HNSCC) not yet exploited therapeutically. TP53 mutation frequently leads to the synthesis of mutant p53 proteins with gain-of-function activity, associated with radioresistance and high incidence of local recurrences in HNSCC.

Experimental Design:
Mutant p53–associated functions were investigated through gene set enrichment analysis in the Cancer Genome Atlas cohort of HNSCC and in a panel of 22 HNSCC cell lines. Mutant p53–dependent transcripts were analyzed in HNSCC cell line Cal27, carrying mutant p53H193L; FaDu, carrying p53R248L; and Detroit 562, carrying p53R175H. Drugs impinging on mutant p53-MYC–dependent signature were identified interrogating Connectivity Map (https://clue.io) derived from the Library of Integrated Network–based Cellular Signatures (LINCS) database (http://lincs.hms.harvard.edu/) and analyzed in HNSCC cell lines and patient-derived xenografts (PDX) models.

Results:
We identified a signature of transcripts directly controlled by gain-of-function mutant p53 protein and prognostic in HNSCC, which is highly enriched of MYC targets. Specifically, both in PDX and cell lines of HNSCC treated with the PI3Kα-selective inhibitor BYL719 (alpelisib) the downregulation of mutant p53/MYC-dependent signature correlates with response to this compound. Mechanistically, mutant p53 favors the binding of MYC to its target promoters and enhances MYC protein stability. Treatment with BYL719 disrupts the interaction of MYC, mutant p53, and YAP proteins with MYC target promoters. Of note, depletion of MYC, mutant p53, or YAP potentiates the effectiveness of BYL719 treatment.

Conclusions:
Collectively, the blocking of this transcriptional network is an important determinant for the response to BYL719 in HNSCC.
A Phase II Basket Trial of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors
Authors: Patel Sandip P. , Othus Megan , Chae Young Kwang , Giles Francis J. , Hansel Donna E. , Singh Preet Paul , Fontaine Annette , Shah Manisha H. , Kasi Anup , Baghdadi Tareq Al , Matrana Marc , Gatalica Zoran , Korn W. Michael , Hayward Jourdain , McLeod Christine , Chen Helen X. , Sharon Elad , Mayerson Edward , Ryan Christopher W. , Plets Melissa , Blanke Charles D. , Kurzrock Razelle 
Published: January 2020

Abstract

Purpose:
Immune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti–CTLA-4 and anti–PD-1 blockade in rare tumors (DART).

Patients and Methods:
We performed a prospective, open-label, multicenter phase II clinical trial of ipilimumab plus nivolumab across multiple rare tumor cohorts, with the (nonpancreatic) neuroendocrine cohort reported here. Response assessment by grade was not prespecified. The primary endpoint was overall response rate [ORR; RECIST v1.1; complete response (CR) and partial response (PR)]; secondary endpoints included progression-free survival (PFS), overall survival (OS), stable disease &gt;6 months, and toxicity.

Results:
Thirty-two eligible patients received therapy; 18 (56%) had high-grade disease. Most common primary sites were gastrointestinal (47%; N = 15) and lung (19%; N = 6). The overall ORR was 25% [95% confidence interval (CI) 13–64%; CR, 3%, N = 1; PR, 22%, N = 7]. Patients with high-grade neuroendocrine carcinoma had an ORR of 44% (8/18 patients) versus 0% in low/intermediate grade tumors (0/14 patients; P = 0.004). The 6-month PFS was 31% (95% CI, 19%–52%); median OS was 11 months (95% CI, 6–∞). The most common toxicities were hypothyroidism (31%), fatigue (28%), and nausea (28%), with alanine aminotransferase elevation (9%) as the most common grade 3/4 immune-related adverse event, and no grade 5 events.

Conclusions:
Ipilimumab plus nivolumab demonstrated a 44% ORR in patients with nonpancreatic high-grade neuroendocrine carcinoma, with 0% ORR in low/intermediate grade disease.
Calcium-Alkali Syndrome Associated with Hypoparathyroidism Following Total Thyroidectomy
Authors: Kuroya Sayaka , Yazawa Masahiko , Shibagaki Yugo , Tominaga Naoto 
Published: January 2020

<b><i>Background:</i></b> Patients with permanent postsurgical hypoparathyroidism, a complication of total thyroidectomy, often require high calcium supplementation with vitamin D to maintain serum calcium levels. The epidemiology of calcium-alkali syndrome (CAS) in patients with hypoparathyroidism after total thyroidectomy remains unclear. This study aimed to investigate the incidence of hypercalcemia, renal impairment, metabolic alkalosis, and CAS in patients treated for presumed hypoparathyroidism after total thyroidectomy. <b><i>Methods:</i></b> Twenty-seven patients with neck cancers who underwent total thyroidectomy without parathyroid autotransplantation between January 2010 and October 2013 at our hospital were consecutively included. All patients received calcium lactate and alfacalcidol for postsurgical hypocalcemia. We defined hypercalcemia as a corrected serum calcium level (cCa) ≥10.5 mg/dL, metabolic alkalosis as a difference in serum sodium and serum chloride ([sNa-sCl]) ≥39 mEq/L, and renal impairment as a ≥50% increase in serum creatine and/or ≥35% decrease in estimated glomerular filtration rate (eGFR) compared to baseline. <b><i>Results:</i></b> cCa peaked (11.1 ± 1.5 mg/dL) at a median of 326 days (interquartile range 78–869) after surgery. At peak cCa, [sNa-sCl] was significantly higher (<i>p</i> &#x3c; 0.01), and eGFR was significantly lower (<i>p</i> &#x3c; 0.01) than that at baseline. Fifteen patients (55.6%) had hypercalcemia, 19 (70.3%) had alkalosis, 12 (44.4%) had renal impairment, and 9 (33.3%) had CAS. Patients with CAS (mean age 67.1 ± 10.8 years) were older than those without CAS (56.7 ± 13.6 years, <i>p</i> = 0.06). The mean dose of alfacalcidol in the CAS group (3.1 ± 1.2 μg/day) was significantly larger than that in the non-CAS group (2.1 ± 1.0 μg/day, <i>p</i> = 0.03). <b><i>Conclusions:</i></b> This retrospective study reveals the high incidence of CAS in patients with hypoparathyroidism after total thyroidectomy. Furthermore, these findings suggest that the serum calcium level, acid-base balance, and renal function should be closely monitored in patients with postsurgical hypoparathyroidism who receive large doses of active vitamin D.
Modelagem geométrica no inventário dos bens patrimoniais
Authors: Bononi Wanda Terezinha , Silva Ricardo Dias 
Published: January 2020

Considerando que os bens patrimoniais são o suporte da memória e podem ser capazes de consolidar ou de construir a identidade de uma sociedade, este artigo tem por objetivo apresentar o inventário 3D da capela Imaculada Conceição, localizada no município de Cruzeiro do Oeste - PR, construção testemunha do período da expansão colonial no território paranaense e representante da cultura daquela sociedade e de sua técnica construtiva singular de construções dos templos religiosos na região. Para tanto, foi preciso desenvolver um protocolo de inventário para edifícios religiosos construídos em madeira, visto que os modelos existentes não atendem, de forma satisfatória, às especificidades desses bens, que necessitam de reparação e substituição de suas peças. A modelagem geométrica tem a capacidade de representar e analisar objetos históricos, produzindo réplicas digitais que possibilitam registro e gerenciamento do patrimônio histórico mais preciso, tornando-se uma ferramenta fundamental para o processo de documentação e valorização do bem.
A cidade moderna na visão de Roberto Arlt
Authors: Santana Bruno Cruz 
Published: January 2020

Este trabalho tem como objetivo estudar as visões da cidade moderna que se desdobram nas crônicas e nos contos de Roberto Arlt, produzidos entre os anos 1920 e 1930. Nestes textos está em foco a cidade de Buenos Aires, num período de intensas transformações políticas, econômicas e sociais provocadas pelos processos de modernização. O estudo das imagens deste novo espaço significa pensar as vanguardas latino-americanas como movimento artístico, embora heterogêneo, definido desde um lugar-comum, a cidade moderna.
Para isso, este estudo focalizará a relação entre crônica e conto, indicadora de uma mescla discursiva moderna que responde aos processos de modernização nos centros urbanos e de legitimação da literatura. A partir disto, voltamos à pergunta sobre a escrita literária no exercício de uma escrita híbrida e flexível que é a crônica moderna, especialmente, o importante papel da crônica na observação das novas experiências urbanas, num processo onde literatura e jornal se inter-relacionam na tentativa de representar a cidade.
Linguagem e escuta nas Aguafuertes Cariocas
Authors: Santos Andreia Moura dos 
Published: January 2020

Nas próximas linhas nos propomos a analisar no livro de crônicas de Roberto Arlt Aguafuertes Cariocas, escritas em 1929 na ocasião de sua visita ao Brasil, a aparição do português, seja em sua forma escrita, seja em forma de escuta. Para tanto, pretendemos verificar nas crônicas como Arlt se apropria e escuta a língua do outro, com o objetivo de averigar de que forma o português se insere na já questionada linguagem arltiana. Buscaremos identificar como e quando o português é a opção do cronista, afim de explicitar o uso territorial que ele faz do idioma além de ponderar sobre a forma como ele se apropria da língua do outro. Também será nosso interesse analisar a forma como Arlt escuta o português: a quem lhe interessava escutar e de que forma. Dessa maneira tentaremos descobrir que tipo de atenção o cronista dá a voz do outro.
Deconstructing Reorienting of Attention: Cue Predictiveness Modulates the Inhibition of the No-target Side and the Hemispheric Distribution of the P1 Response to Invalid Targets
Authors: Doricchi Fabrizio , Pellegrino Michele , Marson Fabio , Pinto Mario , Caratelli Ludovica , Cestari Vincenzo , Rossi-Arnaud Clelia , Lasaponara Stefano 
Published: January 2020

Abstract
Orienting of attention produces a “sensory gain” in the processing of visual targets at attended locations and an increase in the amplitude of target-related P1 and N1 ERPs. P1 marks gain reduction at unattended locations; N1 marks gain enhancement at attended ones. Lateral targets that are preceded by valid cues also evoke a larger P1 over the hemisphere contralateral to the no-target side, which reflects inhibition of this side of space [Slagter, H. A., Prinssen, S., Reteig, L. C., & Mazaheri, A. Facilitation and inhibition in attention: Functional dissociation of pre-stimulus alpha activity, P1, and N1 components. Neuroimage, 125, 25–35, 2016]. To clarify the relationships among cue predictiveness, sensory gain, and the inhibitory P1 response, we compared cue- and target-related ERPs among valid, neutral, and invalid trials with predictive (80% valid/20% invalid) or nonpredictive (50% valid/50% invalid) directional cues. Preparatory facilitation over the visual cortex contralateral to the cued side of space (lateral directing attention positivity component) was reduced during nonpredictive cueing. With predictive cues, the target-related inhibitory P1 was larger over the hemisphere contralateral to the no-target side not only in response to valid but also in response to neutral and invalid targets: This result highlights a default inhibitory hemispheric asymmetry that is independent from cued orienting of attention. With nonpredictive cues, valid targets reduced the amplitude of the inhibitory P1 over the hemisphere contralateral to the no-target side whereas invalid targets enhanced the amplitude of the same inhibitory component. Enhanced inhibition was matched with speeded reorienting to invalid targets and drop in attentional costs. These findings show that reorienting of attention is modulated by the combination of cue-related facilitatory and target-related inhibitory activity.
<p><strong><em>Begonia naga</em></strong><strong>, a synonym of <em>B. manhaoensis </em>(Begoniaceae)</strong></p>
Authors: AUNG AUNG , CHEN WEN-HONG , SHUI YU-MIN 
Published: January 2020

Examination of herbaria specimens and living plants from several populations reveals that the diagnostic characteristics (grooved petioles, acute connectives and fruit wings extremely leaning to pedicles) are exactly consistent between Begonia naga from India and Begonia manhaoensis in China. Therefore, B. naga is treated as a synonym of B. manhaoensis.
Burmanaglaea a new genus and Burmanaglaea felix, a new species from Myanmar (Lepidoptera, Noctuidae, Xylenini)
Authors: BENEDEK BALÁZS , BABICS JÁNOS , VOLYNKIN ANTON V. , SALDAITIS AIDAS 
Published: January 2020

The tribe Xylenini Guenée, is especially rich in the Himalayan region with the highest diversity occurring during the late fall and winter. Exploration of this fauna has a rich history but became especially intensive during recent decades resulting in many new descriptions. Milestones in this vast territorial study by country include Pakistan (Ronkay & Ronkay 1999), India (Hacker 1992), Nepal (Hreblay & Ronkay 1998, Benedek et al. 2013), Taiwan (Hreblay & Ronkay 1997; 2000, Ronkay & Ronkay 2000) Thailand, Vietnam (Hreblay et al. 1999) and China (Ronkay et al. 2010, Benedek et al. 2012; 2013). To this list we now add the mountainous areas of Myanmar which have only recently become accessible. During a late fall collecting trip to Western Myanmar, three specimens of a strange looking noctuid species externally somewhat similar to the Western Himalayan Mniotype leucocyma (Hampson, 1907) were collected. After examination of its male and female genitalia, this species was proven to be new to science. Moreover, the male genitalia of the new species show a surprisingly unusual complex of features, some of which, together with the female genitalia, are characteristic and decisively significant to the subtribe Xylenina. The male and female genitalia of this species are most similar to those of the genera Eupsilia Hübner and Owadaglaea Hacker & Ronkay, however, these genitalia have certain autapomorphic characters which clearly justify separation on generic level. The description of the new genus and species is given below with a comparison to the related Eupsilia and Owadaglaea, several other related genera (Lithophane Hübner, Conistra Hübner and Xylena Ochsenheimer) and the externally similar M. leucocyma as well.