bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 case fatality rates across Southeast Asian countries (SEA): a preliminary estimate using a simple linear regression model
Authors: Puno George R , Puno Rena Christina C , Maghuyop Ida V 
Published: January 2021

PurposeThe purpose of this study was to determine COVID-19 preliminary case fatality rates (CFR) across Southeast Asian (SEA) countries.Design/methodology/approachThe study accessed the data on COVID-19 accumulated cases of fatalities and infections across SEA countries from the World Health Organization (WHO) website, covering the early days of March to May 21, 2020. The approach involved the computation of the CFR using the simple linear regression model. The slope of the regression line was the estimate of the CFR at a 95% confidence interval. The study also reviewed the different approaches of the SEA countries in dealing with the pandemic.FindingsAs of May 21, 2020, Singapore, Indonesia and the Philippines were the top three SEA countries with the highest record of COVID-19 infections. Brunei had one fatality, while Cambodia, Laos, Timor-Leste and Viet Nam had nil fatalities. Indonesia and the Philippines had the highest CFR with 6.66 and 6.59%, with R2 of 97.95 and 99.43%, respectively. Singapore had the lowest CFR (0.068%) despite high infections.Originality/valueIncreased CFR in Indonesia and the Philippines suggests that COVID-19 in the two countries is rising at an alarming rate. Strict implementation of shared management approaches to control the pandemic is seen to be closely associated with the decrease of CFR.
Integration, uncertainty and information: how do they affect planning performance?
Authors: Sagawa Juliana Keiko , Nagano Marcelo Seido 
Published: January 2021

PurposeEffective planning requires the participation of different functions and may be hampered by lack of integration and information quality (IQ). This paper aims to investigate the relationships among integration, uncertainty, IQ and performance, in the context of the production planning and control function. The literature lacks in-depth studies that consider these factors altogether, showing how they interact and how they contribute to improve business performance.Design/methodology/approachThe authors introduce the variable of planning performance, which represents the quality of the production plans/planning process and is related to the frequency and causes of modifications to these plans. The relationships among the mentioned constructs are investigated by means of multiple case studies.FindingsThe results illustrate that integration is positively related to planning performance, and this relationship is mediated by IQ and moderated by uncertainty.Originality/valueThe presented analysis may help practitioners to foster interfunctional integration, better cope with uncertainty and improve information management, aiming to achieve better planning performance. The managers can choose integration and IQ improvement mechanisms that better fit to their environment/reality, using the four different cases as a benchmark. Moreover, this research contributes to the literature exploring this contingency perspective by means of in-depth case studies, considering that most of the existing research adopting this perspective is survey-based.
Sustainable development goals: transportation, health and public policy
Authors: Mohamad Taghvaee Vahid , Assari Arani Abbas , Nodehi Mehrab , Khodaparast Shirazi Jalil , Agheli Lotfali , Neshat Ghojogh Haji Mohammad , Salehnia Nafiseh , Mirzaee Amir , Taheri Saeed , Mohammadi Saber Raziyeh , Faramarzi Hady , Alvandi Reza , Ahmadi Rahbarian Hosein 
Published: January 2021

PurposeThis study aims to assess and decompose the sustainable development using the 17 sustainable development goals (SDGs) in Iran in 2018, for proposing agenda-setting of public policy.Design/methodology/approachIt ranks the SDGs not only in Iran but also in the region and the world to reveal the synergetic effects.FindingsBased on the results, subaltern-populace generally suffers from the hegemonic domination of ruling elite-bourgeois, lack of strong institutions, heterogeneous policy networks and lack of advocacy role of non-governmental organizations, due to no transparency, issues in law or no rule of law, no stringent regulation, rent, suppression and Mafia, all leading to corruption and injustice.Practical implicationsTo stop the loop of corruption-injustice, Iran should homogenize the structure of the policy network. Furthermore, the failed SDGs of the three-geographic analysis are the same in a character; all of them propose SDG 3, good health and well-being as a serious failed goal.Social implicationsIn this regard, strong evidence is the pandemic Coronavirus, COVID 19 since 2019, due to its highly-disastrous consequences in early 2020 where the public policymakers could not adopt policies promptly in the glob, particularly in Iran.Originality/valueIn Iran, in addition to this, the malfunction of health is rooted in “subjective well-being” and “traffic deaths,” respectively. Concerning the transportations system in Iran, it is underscored that it is damaging the sustainable development from all the three pillars of sustainable development including, economic, social and environmental.
Internationalisation and financial performance: in the case of global automotive firms
Authors: Zainudin Rozaimah , Mahdzan Nurul Shahnaz , Mohamad Norzulkarnien Nor 
Published: January 2021

PurposeGiven the mixed evidence on the relationship between internationalisation and firm performance, the purpose of this study is to investigate the effect of internationalisation on the financial performance in the setting of a matured and stagnant market, the global automotive industry.Design/methodology/approachThe study uses 37 automotive manufacturers covering from 2000 to 2015. Panel regression analyses were used to estimate the relationship between four financial performance variables (return on equity [ROE], return on asset [ROA], return on capital [ROC] and return on sales [ROS]) and three main independent variables (foreign assets to total assets [FATA], research and development intensity [RNDi], advertising intensity [ADVi]), controlling for product diversification, firm size, age and risk.FindingsThe findings reveal that automotive firms with a lower FATA ratio, lower RNDi and higher ADVi tend to achieve higher financial performance. However, the intensity of product diversification does not influence the financial performance of global automakers. Ceteris paribus, larger firms in terms of market capitalisation and new entrants into the market tend to have higher financial performance relative to smaller and older firms.Originality/valueThis study contributes to the literature first by examining the relationship between internationalisation and firm performance in the setting of a matured market, i.e. the automotive industry. Secondly, the paper uses a multinational sample at a global level; and third, it analyses financial performance on a comprehensive basis via four measures, namely, ROA, ROE, ROC and ROS, as the dependent variables.
The complex relationships among race/ethnicity, social determinants, and opioid utilization
Authors: Moriya Asako S. , Xu Lanlan 
Published: January 2021

AbstractObjectiveTo examine individual‐ and community‐level factors associated with racial/ethnic differences in individuals’ opioid prescription use.Data SourcesOutpatient opioid prescription utilization and demographic, socioeconomic, and health characteristics from a nationally representative sample of the US noninstitutionalized civilian population obtained from 2013‐2016 Medical Expenditure Panel Survey (MEPS) data and combined with 2012‐2016 American Community Survey data and 2015 Health Area Resources File data.Study DesignWe use the Oaxaca‐Blinder decomposition method to disaggregate racial/ethnic differences in prescription opioid utilization into differences explained by underlying predisposing, enabling and need characteristics, and unexplained differences.Data Collection/Extraction MethodsWe use restricted‐use geographic identifiers to supplement the MEPS data with information on community characteristics and local health care resources.Principal FindingsThe average annual rate of any outpatient opioid prescription use was higher for non‐Hispanic whites (15.8%; standard errors [SE]: 0.3) than for non‐Hispanic blacks and Hispanics by 1.4 percentage points (SE: 0.5) and 6.2 percentage points (SE: 0.4), respectively. The smaller difference between non‐Hispanic blacks and whites is not explained by the differences in the risk factors, while almost all the difference between Hispanics and non‐Hispanic whites can be explained by the differences in the means of the risk factors. The differences in the prevalence of pain, the rate of being United States‐born, and the racial/ethnic composition of the community explain 2.4 (SE: 0.2), 1.4 (SE: 0.3), and 1.9 (SE: 0.4) percentage‐point differences, respectively. Pain prevalence explains the difference regardless of opioid potency, while foreign‐born status and community racial/ethnic composition explain the difference in higher‐potency opioid utilization only.ConclusionsThis study underscores the importance of accounting for both individual and community characteristics when investigating patterns in opioid use. Our results could assist policy makers in tailoring strategies to promote safer and more effective pain management based on individual and community characteristics.
Optimising accuracy of performance predictions using available morphophysiological information in wheat breeding germplasm
Authors: Guberac Sunčica , Galić Vlatko , Rebekić Andrijana , Čupić Tihomir , Petrović Sonja 
Published: January 2021

AbstractWheat breeding programmes often harbour large number of developed progenies. Testing of all progenies in many target environments is not considered cost‐effective, so the genomic predictions are employed. Genomic predictions might be enhanced with adaptational traits given the cost‐effectiveness of their phenotyping. The aim of this study was to assess effectiveness of adding a priori available phenotyping data of adaptational morpho‐physiological traits to genomic predictions in Bayesian framework. The panel of 120 winter wheat genotypes was sown over four growing seasons (2013/2014–2016/2017) in field conditions in two replicates and phenotyped for target traits grain yield and plant height along with nine distinctness, uniformity and stability (DUS) traits. Five genotype groups were defined by the K‐means clustering method based on nine DUS traits. DUS traits were used as fixed covariates in five different genomic prediction models with different assumptions about the distribution densities of marker effects: Bayes A, Bayes B, Bayes C, Bayesian ridge regression and Bayesian lasso. Adding DUS traits as covariates significantly improved accuracies and reduced the root mean square errors (RMSEP) of genomic predictions. Marginal differences between different models were observed. Adding covariates to genomic prediction models might be good strategy to improve accuracies of the predictions by accounting for environmental adaptations, provided their a priori availability or low costs of additional phenotyping.
Regulation of lipid metabolism by the unfolded protein response
Authors: Moncan Matthieu , Mnich Katarzyna , Blomme Arnaud , Almanza Aitor , Samali Afshin , Gorman Adrienne M. 
Published: January 2021

AbstractThe endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition known as ER stress. This leads to activation of the unfolded protein response (UPR) pathway in order to restore protein homeostasis. Three ER membrane proteins, namely inositol‐requiring enzyme 1 (IRE1), protein kinase RNA‐like ER kinase (PERK) and activating transcription factor 6 (ATF6), sense the accumulation of unfolded/misfolded proteins and are activated, initiating an integrated transcriptional programme. Recent literature demonstrates that activation of these sensors can alter lipid enzymes, thus implicating the UPR in the regulation of lipid metabolism. Given the presence of ER stress and UPR activation in several diseases including cancer and neurodegenerative diseases, as well as the growing recognition of altered lipid metabolism in disease, it is timely to consider the role of the UPR in the regulation of lipid metabolism. This review provides an overview of the current knowledge on the impact of the three arms of the UPR on the synthesis, function and regulation of fatty acids, triglycerides, phospholipids and cholesterol.
Prediction of live birth probability after in vitro fertilization and intracytoplasmic sperm injection treatment: A multi‐center retrospective study in Chinese population
Authors: Wen Mingyang , Wu Fang , Du Jiangbo , Lv Hong , Lu Qun , Hu Zhibin , Diao Feiyang , Ling Xiufeng , Tan Jichun , Jin Guangfu 
Published: January 2021

AbstractAimTo develop a prediction model to estimate the chances of live birth over multiple cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment.MethodsA retrospective cohort study was launched in three reproductive centers including 10 824 couples who received 14 106 treatment cycles with known pregnancy outcomes by the end of 2016. Discrete time logistic regression was used to establish the model and a nomogram was developed to predict the chance of live birth on plain paper‐based final predictors.ResultsAmong 10 824 couples, 5809 (53.7%) ended up with a live birth with several successive transplant cycles. What's more, we found that younger female age (p < 0.001), smaller cycle number (p < 0.001), female body mass index (p < 0.001), male factor (p < 0.001), ovulation disorder (p = 0.006), and higher endometrial thickness (p < 0.001) were significantly associated with increased live birth rate. Discrimination of the model expressed by area under the curve (AUC) was 0.66.ConclusionOur study will help shape couples' expectations of their ART outcome, allowing them to plan their treatments more efficiently and prepare emotionally and financially.
Potential effects of dietary probiotics with Chinese herb polysaccharides on the growth performance, immunity, disease resistance, and intestinal microbiota of rainbow trout (Oncorhynchus mykiss)
Authors: Fan Ying , Wang Xiaolu , Wang Youhong , Liu Hongjun , Yu Xiaoqing , Li Le , Ye Haibin , Wang Shuxian , Gai Chunlei , Xu La , Diao Jing , Guo Pingping 
Published: January 2021

AbstractThis study evaluated the effect of probiotics (Clostridium butyricum, Bacillus coagulans) and Chinese herb polysaccharides (Astragalus polysaccharides, APS) on growth performance, immunity, disease resistance, and intestinal microbiota of rainbow trout (Oncorhynchus mykiss). Specimens of O. mykiss (n = 360; 79.9 ± 2.2 g) were fed for 42 days with different diets containing a basal diet (control, C0), supplemented with 109 CFU/kg of C. butyricum + 109 CFU/kg of B. coagulans (E1) and 109 CFU/kg of C. butyricum + 109 CFU/kg of B. coagulans + 100 g/kg of APS (E2) as experimental diets. The results indicated that both E1 and E2 diets increased specific growth rate, reduced feed conversion ratio, and optimized muscle composition. Compared with the control treatment, after trout were fed with E2 diet 42 days, activities of SOD, T‐AOC, and CAT increased significantly, while malondialdehyde content decreased significantly in the E1 treatment. After Aeromonas salmonicida challenge, cumulative mortality was 80%, 41%, and 29% in C0, E1 and E2 treatments, respectively. The abundance of Bacillales, Actinomycetales, and Pseudomonadales increased in the fish intestine of E2 treatment, while that of Rhodobacterales and Rhizobiales decreased. These data showed that C. butyricum + B. coagulans with APS improved growth performance, enhanced immunity and disease resistance, and modulated intestinal microbiota of O. mykiss.
Controlling space, controlling labour? Contested space in food delivery gig work
Authors: Heiland Heiner 
Published: January 2021

AbstractThe article investigates the control of the platform labour process by means of the digital production of space and how workers resist it. The segment of German platform‐mediated food delivery is examined via qualitative interviews and auto‐ethnography. It is shown how the platforms create different spaces to efficiently coordinate and control mobile delivery gig work. Steered by geolocalisation and geofencing, the couriers operate autonomously in spatial corridors defined by the platforms. The agency of the riders is thus limited, but they are occasionally able to undermine the platforms’ spatial control and reinterpret it. The article shows that space is a central but contested instrument for controlling labour.
A Post‐Traumatic Osteoarthritic Model of Hip Following Fracture of Acetabulum in Rabbit: A Preliminary Study by Macroscopic and Radiographic Assessment
Authors: Li Yanjin , Feng Ruibing , Liu Ximing , Wang Guodong , Wang Wei , Lu Qilin , Huang Wei , Wu Haiyang , Cai Xianhua 
Published: January 2021

ObjectiveTo develop a post‐traumatic osteoarthritic model of hip following fracture of acetabulum in rabbit for revealing biochemical mechanism of post‐traumatic osteoarthritis.MethodsA total of 36 mature male New Zealand white rabbits were equally divided into sham group (n = 12), non‐ORIF group (n = 12), and open reduction and internal fixation (ORIF) group (n = 12). Except for the sham group, rabbits had survival surgeries to create acetabular fractures of dorsal wall for simulating dashboard impaction mechanism. The ORIF group received open reduction and internal fixation, while fractures in the non‐ORIF group were left as displaced but transverse fracture and dislocation was reduced. Besides intraoperative appearance and postoperative recovery, macroscopic and radiographic characteristics of the hips were recorded and assessed by a radiographic scoring scale at 3 weeks, 6 weeks, and 6 months, respectively.ResultsOut of 24 modeled acetabula, 21 (87.5%) were pure dorsal wall fractures as proposed and the remaining three were associated fractures (dorsal wall plus transverse fracture) accompanied by dorsal dislocation or not. All hips were stable, and no sciatic nerve injury was observed. One rabbit in the ORIF group died of deep infection 4 days after surgery. Rabbits in the sham and ORIF groups returned to normal gait in 2 weeks, but animals in the non‐ORIF group suffered from limping and restricted movement. As the time progressed, the hips in the non‐ORIF group experienced progressive and severe degeneration which exhibited dramatically malformed and hypertrophic joints at 6 months, but the ORIF group maintained much better morphological structure. Corresponding to morphological changes, the average radiographic scores of the non‐ORIF group increased from 1.25 at 3 weeks to 2.75 at 6 months and showed statistically significant difference when compared to the sham group at all three time points (P = 0.011, 0.011, 0.015, respectively, <0.0167). Although the scores of the ORIF group showed apparent improvements (increased from 0.67 at 3 weeks to 2.00 at 6 months), there was no significant difference between the two modeled groups at all three time points.ConclusionThe fracture model with high consistency and reproducibility showed progressive post‐traumatic osteoarthritic changes which could be improved by open reduction and internal fixation surgery and provided an alternative selection for investigating potential pathogenesis and pathology of post‐traumatic osteoarthritis following fracture of acetabulum.
Utility of endoscopic ultrasound in idiopathic acute recurrent pancreatitis
Authors: Tepox-Padrón Alejandra , Bernal-Mendez Rafael Ambrosio , Duarte-Medrano Gilberto , Romano-Munive Adriana Fabiola , Mairena-Valle Milton , Ramírez-Luna Miguel Ángel , Marroquin-Reyes Jose Daniel , Uscanga Luis , Chan Carlos , Domínguez-Rosado Ismael , Hernandez-Calleros Jorge , Pelaez-Luna Mario , Tellez-Avila Felix 
Published: January 2021

Idiopathic acute recurrent pancreatitis (IARP) is defined as at least two episodes of acute pancreatitis with the complete or near-complete resolution of symptoms and signs of pancreatitis between episodes, without an identified cause. There is a paucity of information about the usefulness of endoscopic ultrasound (EUS) in IARP.ObjectivesTo determine the diagnostic yield of EUS in IARP.DesignA retrospective study was performed in patients with IARP evaluated by EUS between January 2009 and December 2016. Follow-up assessments of acute pancreatitis recurrence were carried out.ResultsSeventy-three patients with 102 EUS procedures were included. EUS was able to identify the cause of IARP in 55 patients (75.3%). The most common findings were chronic pancreatitis in 27 patients (49.1%), followed by lithiasic pathology in 24 patients (43.6%), and intraductal papillary mucinous neoplasm in four patients (7.3%). A directed treatment against EUS findings had a protective tendency associated with the final resolution of recurrence. There were no complications reported.ConclusionEUS performed in patients with IARP helped to identify a possible cause in 2/3 of the cases. The majority of patients have a treatable disease.
PEMCRC anaphylaxis study protocol: a multicentre cohort study to derive and validate clinical decision models for the emergency department management of children with anaphylaxis
Authors: Dribin Timothy E , Michelson Kenneth A , Vyles David , Neuman Mark I , Brousseau David C , Mistry Rakesh D , Dayan Peter S , Zhang Nanhua , Viswanathan Shiv , Witry John , Boyd Stephanie , Schnadower David 
Published: January 2021

IntroductionThere remain significant knowledge gaps about the management and outcomes of children with anaphylaxis. These gaps have led to practice variation regarding decisions to hospitalise children and length of observation periods following treatment with epinephrine. The objectives of this multicentre study are to (1) determine the prevalence of and risk factors for severe, persistent, refractory and biphasic anaphylaxis, as well as persistent and biphasic non-anaphylactic reactions; (2) derive and validate prediction models for emergency department (ED) discharge; and (3) determine data-driven lengths of ED and inpatient observation prior to discharge to home based on initial reaction severity.Methods and analysisThe study is being conducted through the Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC). Children 6 months to less than 18 years of age presenting to 30 participating EDs for anaphylaxis from October 2015 to December 2019 will be eligible. The primary outcomes for each objective are (1) severe, persistent, refractory or biphasic anaphylaxis, as well as persistent or biphasic non-anaphylactic reactions; (2) safe ED discharge, defined as no receipt of acute anaphylaxis medications or hypotension beyond 4 hours from first administered dose of epinephrine; and (3) time from first to last administered dose of epinephrine and vasopressor cessation. Analyses for each objective include (1) descriptive statistics to estimate prevalence and generalised estimating equations that will be used to investigate risk factors for anaphylaxis outcomes, (2) least absolute shrinkage and selection operator regression and binary recursive partitioning to derive and validate prediction models of children who may be candidates for safe ED discharge, and (3) Kaplan-Meier analyses to assess timing from first to last epinephrine doses and vasopressor cessation based on initial reaction severity.Ethics and disseminationAll sites will obtain institutional review board approval; results will be published in peer-reviewed journals and disseminated via traditional and social media, blogs and online education platforms.