bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biosimilarity Assessment of 2 Filgrastim Therapeutics in Healthy Volunteers
Authors: Khandoozi Seyed Reza , Shahbazi Majid , Amini Hossein 
Published: August 2020

AbstractThis study aimed to compare the pharmacokinetic, pharmacodynamic, and safety profiles of a proposed biosimilar and innovator filgrastim therapeutics in healthy volunteers. In a crossover design, 23 subjects received a single subcutaneous injection of 300‐µg filgrastim, followed by a 7‐day washout period. Assessed pharmacokinetic parameters were the maximum observed filgrastim serum concentration (Cmax), time to reach Cmax (tmax), the area under the concentration‐time curve (AUC), and elimination half‐life. Pharmacodynamics were assessed by the maximum observed absolute neutrophil count effect (Emax), tmax,E (time to reach Emax), and the area under the effect of the absolute neutrophil count –time curve. The test/reference ratio (90% confidence intervals) of Cmax of 0.992 (0.860‐1.143), AUC0–inf of 0.995 (0.891‐1.111), Emax of 0.952 (0.841, 1.078), and area under the effect of the absolute neutrophil count –time curve from time zero to 96 hours of 0.939 (0.854‐1.032), were all well within the predefined equivalence boundaries of 80% and 125%. Obtained values for tmax (∼4 hours), tmax,E (∼15 hours), and elimination half‐life (∼3.5 hours) were comparable between 2 treatment groups. The local tolerability and incidence of adverse events were comparable, with no clinically meaningful difference between biosimilar and innovator products. Altogether, the results suggested a high similarity of the proposed biosimilar to the innovator filgrastim in healthy volunteers.
Copper‐Catalyzed Aqueous N−O Bond Cleavage of 2‐Oxa‐3‐Azabicyclo Compounds to Cyclic cis‐1,4‐Amino Alcohols
Authors: Yasukawa Naoki , Miki Yuya , Kuwata Marina , Sajiki Hironao , Sawama Yoshinari 
Published: August 2020

AbstractThe N−O bond cleavage of 2‐oxa‐3‐azabicyclo substrates, which are readily prepared by the hetero Diels‐Alder reaction between nitroso dienophiles and cyclic 1,3‐dienes, was effectively catalyzed by heterogeneous copper‐on‐carbon (Cu/C) under aqueous conditions to give the corresponding cyclic cis‐1,4‐amino alcohol derivatives. The present method was applied to the direct incorporation of the hydroxy and amino groups derived from a nitroso substrate into cyclic 1,3‐dienes with cis‐selectivity by the combination of the in situ formation of 2‐oxa‐3‐azabicyclo compounds and following Cu/C‐catalyzed N−O bond cleavage. The obtained cis‐4‐aminocyclohexenols, derived from cyclohexadiene as a cyclic 1,3‐diene, could be selectively oxidized by using the ruthenium‐on‐carbon (Ru/C) catalyst under oxygen atmosphere to the corresponding 4‐aminocyclohexenones at 50–65 °C or para‐iminoquinones at 100–110 °C as useful reactive synthetic precursors.
On‐site cytological diagnosis of cylindroma: A case report
Authors: Tummidi Santosh , Nagiredla Puneeta 
Published: August 2020

AbstractA 70‐year‐old female presented with a swelling in the right auricle for 6 months. Rapid onsite stain and routine cytology revealed clusters of small, round to oval cells with hyperchromatic nuclei, inconspicuous nucleoli, and scant cytoplasm. The background had basement membrane type material and appeared dark magenta colored pinkish globular material. Hence a cytological diagnosis of skin adnexal tumor possibly cylindroma was made. The excision of the lesion also showed features of cylindroma. Rapid onsite staining and cytology of subcutaneous location of the tumor in the absence of primary salivary gland tumors may help to diagnose such rare cases.
Temperature dependency of predation: Increased killing rates and prey mass consumption by predators with warming
Authors: Walker Ryan , Wilder Shawn M. , González Angélica L. 
Published: August 2020

AbstractTemperature dependency of consumer–resource interactions is fundamentally important for understanding and predicting the responses of food webs to climate change. Previous studies have shown temperature‐driven shifts in herbivore consumption rates and resource preference, but these effects remain poorly understood for predatory arthropods. Here, we investigate how predator killing rates, prey mass consumption, and macronutrient intake respond to increased temperatures using a laboratory and a field reciprocal transplant experiment. Ectothermic predators, wolf spiders (Pardosa sp.), in the lab experiment, were exposed to increased temperatures and different prey macronutrient content (high lipid/low protein and low lipid/high protein) to assess changes in their killing rates and nutritional demands. Additionally, we investigate prey mass and lipid consumption by spiders under contrasting temperatures, along an elevation gradient. We used a field reciprocal transplant experiment between low (420 masl; 26°C) and high (2,100 masl; 15°C) elevations in the Ecuadorian Andes, using wild populations of two common orb‐weaver spider species (Leucauge sp. and Cyclosa sp.) present along the elevation gradient. We found that killing rates of wolf spiders increased with warmer temperatures but were not significantly affected by prey macronutrient content, although spiders consumed significantly more lipids from lipid‐rich prey. The field reciprocal transplant experiment showed no consistent predator responses to changes in temperature along the elevational gradient. Transplanting Cyclosa sp. spiders to low‐ or high‐elevation sites did not affect their prey mass or lipid consumption rate, whereas Leucauge sp. individuals increased prey mass consumption when transplanted from the high to the low warm elevation. Our findings show that increases in temperature intensify predator killing rates, prey consumption, and lipid intake, but the responses to temperature vary between species, which may be a result of species‐specific differences in their hunting behavior and sensitivity to temperature.
Female zebra finches prefer the songs of males who quickly solve a novel foraging task to the songs of males unable to solve the task
Authors: Howell Clara , Anderson Rindy , Derryberry Elizabeth P. 
Published: August 2020

AbstractCorrelative evidence suggests that high problem‐solving and foraging abilities in a mate are associated with direct fitness advantages, so it would benefit females to prefer problem‐solving males. Recent work has also shown that females of several bird species who directly observe males prefer those that can solve a novel foraging task over those that cannot. In addition to or instead of direct observation of cognitive skills, many species utilize assessment signals when choosing a mate. Here, we test whether females can select a problem‐solving male over a non‐solving male when presented only with a signal known to be used in mate assessment: song. Using an operant conditioning assay, we compared female zebra finch (Taeniopygia guttata) preference for the songs of males that could quickly solve a novel foraging task to the songs of males that could not solve the task. Females were never housed with the test subject males whose song they heard, and the only information provided about the males was their song. We found that females elicited more songs of problem‐solving males than of non‐solvers, indicating that song may contain information about a male’s ability to solve a novel foraging task and that naïve females prefer the songs of problem‐solving males.
Domestication of international norms for sustainable resource governance: Elite capture in Peru
Authors: Gustafsson Maria‐Therese , Merino Roger , Scurrah Martin 
Published: August 2020

AbstractIn recent years, international actors have promoted international norms related to sustainable and inclusive resource governance. However, we know little about how such attempts are contested and adapted in domestic reform processes. Drawing on insights from norm diffusion and institutionalist theories, this article traces how first bilateral aid agencies and then OECD have influenced the institutionalisation of a contested land‐use planning (LUP) reform in Peru from 1990 until 2017. Based on 145 interviews and written primary sources, we demonstrate that aid agencies have partially empowered policy coalitions (e.g., civil society and subnational actors) in favour of LUP, whereas OECD's interventions have favoured national elites opposed to LUP. In both cases, we argue that by failing to foresee the political resistance among economic actors and national elites, international actors have contributed to the weakening and elite capture of LUP. Hence, our analysis represents a case of weakly institutionalized norms. The findings extend the existing literature on extractive governance by providing a fine‐grained analysis of the process in which national elites and societal coalitions domesticate the institutionalisation of international norms for sustainable and inclusive resource governance. Our findings have broader implications for debates about extractive governance as well as policy strategies for promoting institutional change in resource‐rich middle‐income countries.
Fabrication of Sensitive Membrane Electrodes and their Application in Electrochemical Quantification of Ibandronate in Dosage Form
Authors: Abdel‐Gawad Sherif A. , Alamri Mubarak A. 
Published: August 2020

AbstractA new, highly selective, simple and accurate method was adopted and validated for the direct quantification of ibandronate sodium monohydrate (IBN) in tablets using sensitive polyvinyl chloride membrane electrodes. Three membranes were fabricated using dibutyl sebacate, nitrophenyl octyl ether and dioctyl phthalate. The fabricated electrodes showed fast response, capability of application in wide pH range and direct determination of IBN in turbid solutions. The most important advantage of the proposed analytical method is that it successfully allows direct determination of IBN in dosage form. The proposed analytical methodology can be applied for the direct quantification of IBN in pharmaceutical formulations.
Runoff‐generated debris flows: Observation of initiation conditions and erosion–deposition dynamics along the channel at Cancia (eastern Italian Alps)
Authors: Simoni Alessandro , Bernard Martino , Berti Matteo , Boreggio Mauro , Lanzoni Stefano , Stancanelli Laura Maria , Gregoretti Carlo 
Published: August 2020

AbstractIn the Dolomitic region, abundant coarse hillslope sediment is commonly found at the toe of rocky cliffs. Ephemeral channels originate where lower permeability bedrock surfaces concentrate surface runoff. Debris flows initiate along such channels following intense rainfall and determine the progressive erosion and deepening of the channels. Sediment recharge mechanisms include rock fall, dry ravel processes and channel‐bank failures. Here we document debris flow activity that took place in an active debris flow basin during the year 2015. The Cancia basin is located on the southwestern slope of Mount Antelao (3264 m a.s.l.) in the dolomitic region of the eastern Italian Alps. The 2.5 km2 basin is incised in dolomitic limestone rocks. The data consist of repeated topographic surveys, distributed rainfall measurements, time‐lapse (2 s) videos of two events and pore pressure measurements in the channel bed. During July and August 2015, two debris flow events occurred, following similarly intense rainstorms. We compared rainfall data to existing rainfall triggering thresholds and simulated the hydrological response of the headwater catchment with a distributed model in order to estimate the total and peak water discharge. Our data clearly illustrate how debris entrainment along the channel is the main contributor to the overall mobilized volume and that erosion is dominant when the channel slope exceeds 16°. Further downstream, sediment accumulation and depletion occurred alternately for the two successive events, indicating that sediment availability along the channel also influences the flow behaviour along the prevailing‐transport reach. The comparison between monitoring data, topographical analysis and hydrological simulation allows the estimation of the average solid concentration of the two events and suggests that debris availability has a significant influence on the debris flow volume. © 2020 John Wiley & Sons, Ltd.
Sum‐rate maximization in uplink cell‐free massive multiinput multioutput system with jamming
Authors: Zhang Yao , Zhou Meng , Cao Haotong , Yang Longxiang , Zhu Hongbo 
Published: August 2020

AbstractThis article takes the first look at jamming attacks on both uplink training and data transmission phases in uplink cell‐free massive multi‐input multi‐output systems. Closed‐form rate expressions for that system are derived, which provide us with the opportunities to analyze the achievable rate in the presence of jamming. To compensate for the sum‐rate degradation caused by jamming, we propose an iterative sum‐rate maximization power control algorithm without redesigning the estimator and receiver. Specifically, by virtue of the Lagrange multiplier methodology, the proposed algorithm can determine the closed‐form solution to each iteration and thus, benefiting from less runtime. Simulation results reveal the effectiveness of the proposed algorithm.
Assessment of genotype‐trait interaction in maize (Zea mays L.) hybrids using GGT biplot analysis
Authors: Shojaei Seyed Habib , Mostafavi Khodadad , Khosroshahli Mahmoud , Reza Bihamta Mohammad , Ramshini Hossein 
Published: August 2020

AbstractIn order to investigate the interaction of genotype × trait and relationships among agronomic traits on 12 maize hybrids, an experiment was conducted in a randomized complete block design (RCBD) with three replicates in four regions of Karaj, Birjand, Shiraz, and Arak. Results of analysis of variance indicated that most of the genotypes were significantly different in terms of agronomic traits. Mean comparison by Duncan's method showed that KSC705 genotype was more favorable than other genotypes in all studied regions. SC604 genotype in Birjand and Karaj regions and KSC707 genotype in Shiraz region have higher rank than other genotypes. Correlation analysis was used to investigate the relationships between traits. In most of the studied regions, traits of number of grains in row and number of rows per ear were positively and significantly correlated with grain width and grain weight with grain yield. Graphical analysis was used to further investigate. Genotypes–trait interaction graph explained 59.27%, 61.22%, 59.17%, and 61.95% of total variance in Karaj, Birjand, Shiraz, and Arak, respectively. Based on the multivariate graph, KSC705, KSC706, and SC647 genotypes were identified as superior genotypes in all studied regions and KSC400 genotype did not show much response to change in traits. Correlation between grain width and number of rows in ear, plant height and grain length, one thousand grain weight and grain thickness, and ear diameter with number of grains in row was positive and significant. The results of classification graph of genotypes also divided the cultivars in to three groups as follows: KSC703, KSC400, and KSC706 genotypes in the first group; DC370, SC604, and SC301 in the second group; and KSC260, KSC704, KSC707, and SC301 in the third group.
Neural representational similarity between L1 and L2 in spoken and written language processing
Authors: Kim Say Young , Liu Lanfang , Liu Li , Cao Fan 
Published: August 2020

AbstractDespite substantial research on the brain mechanisms of L1 and L2 processing in bilinguals, it is still unknown whether language modality (i.e., visual vs. auditory) plays a role in determining whether L1 and L2 are processed similarly. Therefore, we examined the neural representational similarity in neural networks between L1 and L2 in spoken and written word processing in Korean–English–Chinese trilinguals. Participants performed both visual and auditory rhyming judgments in the three languages: Korean, English, and Chinese. The results showed greater similarity among the three languages in the auditory modality than in the visual modality, suggesting more differentiated networks for written word processing in the three languages than spoken word processing. In addition, there was less similarity between spoken and written word processing in L1 than the L2s, suggesting a more specialized network for each modality in L1 than L2s. Finally, the similarity between the two L2s (i.e., Chinese and English) was greater than that between each L2 and L1 after task performance was regressed out, especially in the visual modality, suggesting that L2s are processed similarly. These findings provide important insights about spoken and written language processing in the bilingual brain.
Decreased cortical thickness mediates the relationship between premature birth and cognitive performance in adulthood
Authors: Schmitz‐Koep Benita , Bäuml Josef G. , Menegaux Aurore , Nuttall Rachel , Zimmermann Juliana , Schneider Sebastian C. , Daamen Marcel , Scheef Lukas , Boecker Henning , Zimmer Claus , Gaser Christian , Wolke Dieter , Bartmann Peter , Sorg Christian , Hedderich Dennis M. 
Published: August 2020

AbstractCortical thickness (CTh) reflects cortical properties such as dendritic complexity and synaptic density, which are not only vulnerable to developmental disturbances caused by premature birth but also highly relevant for cognitive performance. We tested the hypotheses whether CTh in young adults is altered after premature birth and whether these aberrations are relevant for general cognitive abilities. We investigated CTh based on brain structural magnetic resonance imaging and surface‐based morphometry in a large and prospectively collected cohort of 101 very premature‐born adults (<32 weeks of gestation and/or birth weight [BW] below 1,500 g) and 111 full‐term controls at 26 years of age. Cognitive performance was assessed by full‐scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale. CTh was reduced in frontal, parietal, and temporal associative cortices predominantly in the left hemisphere in premature‐born adults compared to controls. We found a significant positive association of CTh with both gestational age and BW, particularly in the left hemisphere, and a significant negative association between CTh and intensity of neonatal treatment within limited regions bilaterally. Full‐scale IQ and CTh in the left hemisphere were positively correlated. Furthermore, CTh in the left hemisphere acted as a mediator on the association between premature birth and full‐scale IQ. Results provide evidence that premature born adults have widespread reduced CTh that is relevant for their general cognitive performance. Data suggest lasting reductions in cortical microstructure subserving CTh after premature birth.
The effects of public health insurance on health behaviors: Evidence from the fifth year of Medicaid expansion
Authors: Soni Aparna 
Published: August 2020

AbstractThis study examines the longer term relationship between public health insurance expansions and health behaviors. I leverage geographic and temporal variation in the implementation of the Affordable Care Act‐facilitated Medicaid expansions and provide the first estimates of the expansions' behavioral impacts during their first 5 years. Using national survey data from the 2010 to 2018 Behavioral Risk Factors Surveillance System and a difference‐in‐differences regression design, I show that the Medicaid expansions increase utilization of certain forms of preventive care, while reducing heavy drinking. I also find suggestive evidence that the expansions reduce smoking and increase the probability of exercise. These results stand in contrast with earlier studies that used only 2 or 3 years of postexpansion data and found no detectable effect of the Medicaid expansions on health behaviors in the short run. My results, combined with evidence from previous studies, suggest that public insurance expansions may not prompt an immediate change in health behaviors, but newly eligible populations do increase investments in healthy behaviors over time. In the long run, Medicaid expansions may help reduce engagement in risky behaviors like drinking and smoking among low‐income people.
Hammond Hill Research Catchment: Supporting hydrologic investigations of rooting zone and vegetation water dynamics under climate change
Authors: Knighton James , Singh Kanishka , Souter‐Kline Valessa , Walter M. Todd 
Published: August 2020

AbstractThe Hammond Hill Research Catchment (HH) is a small (120 ha), temperate, second order tributary to Six Mile Creek, Cayuga Lake, and the Great Lakes (42.42°, −76.32°). The HH has been monitored since January 2017 for the purpose of understanding how recent infiltration mixes with antecedent soil water on hillslope forest floors and the spatial and temporal patterns of Root Water Uptake (RWU) by temperate northeastern US tree species (eastern hemlock [Tsuga canadensis], American beech [Fagus grandifolia], and sugar maple [Acer saccharum]). These data are informing us about the hydrologic consequences of anticipated tree species composition change and supporting the development of more refined ecohydrological models. The glaciated catchment is underlain by a shallow confining siltstone layer (1–1.5 m depth) and densely covered with an approximately 60 year old regrowth mixed species forest of hemlock, beech, and other deciduous tree species common to the northeastern US. Current datasets from the HH include precipitation snow water equivalent, discharge, and associated isotopic water compositions, δ2H & δ18O. Measurements of (top 10 cm) soil water content, as well as bulk soil water and hemlock and beech xylem isotopic compositions are made at several locations across a topographic wetness gradient. The near‐term role of the HH is to support an understanding of the environmental and ecological drivers of plant RWU competition. All data from the HH are publicly available.
Determinants of comparative advantage of crude oil production: Evidence from OPEC and non‐OPEC countries
Authors: Elsalih Osama , Sertoglu Kamil , Besim Mustafa 
Published: August 2020

AbstractThis study investigates the determinants of comparative advantage of crude oil production in 10 OPEC and 10 non‐OPEC countries over the period 1990–2016. The study calculates the comparative advantage using the Normalized Revealed Comparative Advantage index (NRCA) and further estimates the relationship between the comparative advantage and three explanatory variables using panel autoregressive distributed lag (panel ARDL) in a separate panel for each group of countries. The result of NRCA shows that all OPEC countries have a comparative advantage in crude oil production, whereas five of the 10 non‐OPEC countries have a comparative advantage in crude oil production. The result of the ARDL indicates that crude oil price (COP) and average of daily production (ADP) positively affect comparative advantage of crude oil production. The effect of natural resources (PR) is negative, suggesting that an increase in PR decreases the comparative advantage of these countries—a result that aligns with the philosophy of Hotelling rent. Finally, bidirectional Granger causality is established between all the investigated variables in both panels.