bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adsorption of NO2, HCN, HCHO and CO on pristine and amine functionalized boron nitride nanotubes by self-consistent charge density functional tight-binding method
Authors: Timsorn Kriengkri , Wongchoosuk Chatchawal 
Published: April 2020

Abstract
The adsorptions of toxic gases including NO2, HCN, HCHO and CO molecules on the pristine and amine functionalized (5,0) single-wall boron nitride nanotubes (BNNTs) are investigated based on self-consistent charge density functional tight-binding (SCC-DFTB) method. The calculated results indicate that the pristine (5,0) BNNT exhibits weak adsorption for the gas molecules. Based on the calculated adsorption energy, interaction distances and charge transfer, amine functionalization at a boron atom of the pristine (5,0) BNNT enhances the sensitivity of the pristine (5,0) BNNT toward the gas molecules. The electronic densities of state results reveal that new local states in the vicinity of Fermi level for adsorption between amine functionalized BNNT and the gas molecules significantly appear. This confirms the improved sensitivity of the pristine (5,0) BNNT functionalized with amine for adsorption of the toxic gases. This study is expected to provide a useful guidance on gas sensing application of pristine and amine functionalized BNNTs for detection of the toxic gases at room temperature.
Skirmishing MDR strain of Candida albicans by effective antifungal CeO2 nanostructures using Aspergillus terreus and Talaromyces purpurogenus
Authors: Komal Rimsha , Uzair Bushra , Sajjad Shamaila , Butt Sajid , Kanwal Amna , Ahmed Iftikhar , Riaz Naveeda , Leghari Sajjad Ahmed Khan , Abbas Sehrish 
Published: April 2020

Abstract
Emerging antibiotics resistance fungal infectionsis a major global health problem and new antifungal formulations are direly needed to fight drug resistant Candida albicans strains. This study is aimed to synthesize effective antifungal nanostructures of cerium oxide (CeO2) using culture filtrates of two common fungal strains Aspergillus terreus and Talaromyces pupureogenus. The fungal strains used in the synthesis were identified by 18S rRNA gene sequencing and deposited to NCBI GenBank with the accession number of MN099077 and MN121629, respectively. The biofabricated CeO2 NPs were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Pure CeO2 nanoparticles (NPs) synthesized using Aspergillus terreus culture filtrate were depicted spherical morphology with average size of 28.5 nm. The CeO2NPs synthesized using Talaromyces pupureogenus revealed the presence of nanosponges with average size of 21.4 nm. Gas chromatography mass spectrometry of culture filtrates of respective strains indicated the presence of ethanol, 1-propanol and tri-chloromethane in culture filtrate of Aspergillus terreus and with addition of palmitic acid in Talaromyces pupureogenus culture filtrate which may have a function as bio reducers and capping agents. Dose dependent anticandidal activity of CeO2 NPs using various different concentrations (100, 200, 300, 600 μg ml−1) synthesized by both fungal strains was observed by disc diffusion assay against Candida albicansas evidenced by increase in size of zone of inhibitions with increasing concentration of CeO2NPs. Further in-vitro and in-vivo experiments are required to access the potential of CeO2 NPs for controlling Candida albicans strains.
Association between triclosan levels and white blood cell counts in US adults from NHANES, 2011–2012
Authors: Yan Judy , Joseph Michael A , Reynolds Simone A , Veenema Ryne J , Geer Laura A 
Published: April 2020

Abstract
Triclosan is a broad-spectrum antimicrobial agent used in a multitude of healthcare and consumer products. Epidemiological studies link triclosan exposure to several adverse health outcomes including alterations in thyroid function and an increased risk for allergies and asthma suggesting an immunomodulatory role for the endocrine disrupting synthetic chemical. The effects of triclosan on the human immune system, particularly on the levels and function of white blood cells, have yet to be fully characterized. Using cross-sectional data from the NHANES 2011–2012 survey, we examined the relationship between triclosan exposure levels and white blood cell counts in adults 18–65 years of age. Results from multivariable linear regression analysis show lack of a statistically signficant association between urinary triclosan levels and white blood cell counts (β = −0.0007, p = 0.90, 95% CI = −0.012, 0.010). Findings may demonstrate an absence of association or may indicate that triclosan exposure levels were too low to have a significant detectable impact on white blood cell counts. Considering that prior animal and epidemiological studies have established links between triclosan exposure and alterations in immune system parameters and susceptibility to allergic diseases, the effects of triclosan exposure on the immune system should continue to be evaluated.
Collinear setup for delay control in two-color attosecond measurements
Authors: Ahmadi H , Kellerer S , Ertel D , Moioli M , Reduzzi M , Maroju P K , Jäger A , Shah R N , Lutz J , Frassetto F , Poletto L , Bragheri F , Osellame R , Pfeifer T , Schröter C D , Moshammer R , Sansone G 
Published: April 2020

Abstract
We present a compact experimental setup for performing attosecond-pump-infrared-probe experiments with long-time delay stability. The robustness of the setup is demonstrated over a two-day acquisition time in two-photon photoionization of argon in the photon-energy range 17−33 eV. The propagation of the input infrared pulse, as driving pulse for the high-order harmonic generation process and for the generation of the sidebands of the main photoelectron peaks, through the main optical components is simulated and discussed. Our setup allows us to perform attosecond experiments with an overall stability of ± 40 as.
St. Xenia and the Gleaners of Leningrad
Authors: Cherkaev Xenia 
Published: April 2020

Abstract
This text is, above all, a grateful testament to a local saint’s continued liveliness. It is a new hagiography, a story of a woman who gave away everything—her house, her money, her possessions, and even her name—who wandered homeless, and who has helped people resolve desperate situations ever since. Retelling the fragmented stories of how people asked for her intervention, and of how, through their actions, new mycelia of power grew on the ruins of the Soviet socialist state, I hope that this essay helps opens a loophole: a space between naïve faith and sociological faithlessness in which we might understand today’s miracles without crushing them by the secular objectivist gaze. Looking through this loophole, this essay retells some of stories I heard about the Soviet collapse and about how people survived it: about gleaning the planned economy’s rubble, chance connections, personal ties, Divine Providence, fast fortunes, and the enclosure of fields.
Renamed: The Living, the Dead, and the Global in Nineteenth-Century U.S. Christianity
Authors: Kaell Hillary 
Published: April 2020

Abstract
Over the nineteenth century, thousands of North Americans and Europeans paid to sponsor and rename foreign children in mission stations across the world. This popular fundraising model has been largely unstudied to date. When the extant records are pieced together, it becomes evident that U.S. Protestants commonly renamed foreign children after their own beloved dead. As a result, these programs offer important insight into how Americans who never traveled abroad still cultivated global subjectivities—in this case, through their connections with other-than-human presences. By nurturing relations with what they viewed as globally active agents, such as God, angels, and the dead, U.S. donors cultivated a sense of themselves as subjects who were Christian, American, and globally active. For mourning families, renaming also seemed to impress their dead’s “qualities” onto foreign children, creating what they viewed as opportunities to collaborate with the dead and reconstitute some aspect of ruptured domestic relations. Focusing on a group often assumed to be the most disenchanted of nineteenth-century moderns—U.S. Protestants in the rising middle class—this article calls for more attention to the “otherworldly” in histories of global relations.
In Their Own Words: Judith Weis
Authors: Verdier James 
Published: April 2020

Abstract
In Their Own Words chronicles the stories of scientists who have made great contributions to their fields, particularly within the biological sciences. These short oral histories provide our readers a way to learn from and share their experiences. Each month, we will publish in the pages of BioScience and in our podcast, BioScience Talks (http://bioscienceaibs.libsyn.com), the results of these conversations. This oral history is with Dr. Judith Weis of Rutgers University. She previously served as president of the American Institute of Biological Sciences.
Note: Both the text and audio versions have been edited for clarity and length.
Loss of MINAR2 impairs motor function and causes Parkinson’s disease-like symptoms in mice
Authors: Ho Rachel Xi-Yeen , Amraei Razie , De La Cena Kyle Oliver Corcino , Sutherland Evan G , Mortazavi Farzad , Stein Thor , Chitalia Vipul , Rahimi Nader 
Published: April 2020

AbstractParkinson’s disease is the second most common human neurodegenerative disease. Motor control impairment represents a key clinical hallmark and primary clinical symptom of the disease, which is further characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of α-synuclein aggregations. We have identified major intrinsically disordered NOTCH2-associated receptor 2 encoded by KIAA1024L, a previously uncharacterized protein that is highly conserved in humans and other species. In this study, we demonstrate that major intrinsically disordered NOTCH2-associated receptor 2 expression is significantly down-regulated in the frontal lobe brain of patients with Lewy body dementia. Major intrinsically disordered NOTCH2-associated receptor 2 is predominantly expressed in brain tissue and is particularly prominent in the midbrain. Major intrinsically disordered NOTCH2-associated receptor 2 interacts with neurogenic locus notch homologue protein 2 and is localized at the endoplasmic reticulum compartments. We generated major intrinsically disordered NOTCH2-associated receptor 2 knockout mouse and demonstrated that the loss of major intrinsically disordered NOTCH2-associated receptor 2 in mouse results in severe motor deficits such as rigidity and bradykinesia, gait abnormalities, reduced spontaneous locomotor and exploratory behaviour, symptoms that are highly similar to those observed in human Parkinson’s spectrum disorders. Analysis of the major intrinsically disordered NOTCH2-associated receptor 2 knockout mice brain revealed significant anomalies in neuronal function and appearance including the loss of tyrosine hydroxylase-positive neurons in the pars compacta, which was accompanied by an up-regulation in α-synuclein protein expression. Taken together, these data demonstrate a previously unknown function for major intrinsically disordered NOTCH2-associated receptor 2 in the pathogenesis of Parkinson’s spectrum disorders.
Motivational Interviewing to Support Oral AntiCoagulation adherence in patients with non-valvular Atrial Fibrillation (MISOAC-AF): a randomized clinical trial
Authors: Tzikas Apostolos , Samaras Athanasios , Kartas Anastasios , Vasdeki Dimitra , Fotos George , Dividis George , Paschou Eleni , Forozidou Evropi , Tsoukra Paraskevi , Kotsi Eleni , Goulas Ioannis , Karvounis Haralambos , Giannakoulas George 
Published: April 2020

Abstract

Aims
We aimed to assess the impact of an educational, motivational intervention on the adherence to oral anticoagulation (OAC) in patients with non-valvular atrial fibrillation (AF).

Methods and results
Hospitalized patients with non-valvular AF who received OAC were randomly assigned to usual medical care or a proactive intervention, comprising motivational interviewing, and tailored counselling on medication adherence. The primary study outcome was adherence to OAC at 1 year, which was evaluated according to proportion of days covered (PDC) by OAC regimens and was assessed through nationwide registers of prescription claims. Secondary outcomes included the rate of persistence to OAC, gaps in treatment, and clinical events. A total of 1009 patients were randomized, 500 in the intervention group and 509 in the control group. At 1-year follow-up, 77.2% (386/500) of patients in the intervention group were adherent (PDC &gt; 80%), compared with 55% (280/509) in the control group [adjusted odds ratio (aOR) 2.84, 95% confidence interval (CI) 2.14–3.75; P &lt; 0.001]. Mean PDC ± standard deviation was 0.85 ± 0.26 and 0.75 ± 0.31, respectively (P &lt; 0.001). Patients that received the intervention were more likely to persist in their OAC therapy at 1 year (aOR 2.42, 95% CI 1.71–3.41; P &lt; 0.001). Usual medical care was associated with more major (≥3 months) treatment gaps (aOR 2.39, 95% CI 1.76–3.26; P &lt; 0.001). Clinical events over a median follow-up period of 2 years did not differ among treatment groups.

Conclusion
In patients receiving OAC therapy for non-valvular AF, a multilevel motivational intervention significantly improved medication adherence and rate of therapy persistence, and reduced major gaps in treatment. No significant impact on clinical outcomes was observed.

Trial registration number
NCT02941978.
Evaluation and optimization of air-based precooling for higher postharvest quality: literature review and interdisciplinary perspective
Authors: Wang Guanbang , Zhang Xinrong 
Published: April 2020

Abstract
Precooling is of significant importance for postharvest fruits and vegetables to control the quality degradation and prolong the shelf-life. Current precooling methods include room cooling, forced-air cooling, hydrocooling, vacuum cooling, contact or package icing, and cryogenic cooling, all of which have their advantages and disadvantages. The first two methods with the cooling medium of air are extensively used because of the wide applicable range of fruits and vegetables. Numerous studies have been devoted to cope with the drawbacks of these two air-based precooling methods with various evaluation criteria and optimization methods. A systematic literature review on these studies is firstly conducted with respect to experimental and numerical investigations respectively for the two methods. The main contributions from the previous studies are also summarized respectively with the research objectives and performance metrics. The literature review indicates that the current performance evaluation is limited to apparent parameters and the optimal design is only proposed based on the performance evaluation and comparison. Furthermore, with inspiration from the research in other domains, a scheme of advanced evaluation and optimization for air-based precooling methods is proposed with thermodynamic evaluation metrics and constructal optimization methods from the interdisciplinary perspective.
A review on the consumption of vended fruits: microbial assessment, risk, and its control
Authors: Igiehon Oluwakemi Osarumwense , Adekoya Ademola Ezekiel , Idowu Anthony Temitope 
Published: April 2020

AbstractFruits are very beneficial to health and their consumption has been recommended in daily diets. However, when fresh fruits are harvested and processed into sliced ready-to-eat or vended forms for sale, hygienic procedures are neglected. Thus, they are easily infested by pathogens. In addition, uneducated vendors who sell these fruits often display or hawk them on the streets in contaminated containers, utensils, or dirty environments. This poses a great threat to the health of consumers. In the light of this realization, some microbial assessments have been carried out to ascertain the safety of these vended fruits, thus making it a necessity to exploit the outcomes of some of these microbial assessments on vended fruits in order to sensitize the consumers on the effect of their consumption and mitigate risk by improving their quality. This will assist to lower certain health concerns, an outbreak of diseases, and death.
Exemplification Effects: A Meta-Analysis
Authors: Krämer Benjamin , Peter Christina 
Published: April 2020

Abstract
The presentation of single cases as examples for larger phenomena has a long-standing tradition in journalism. However, their usage has been viewed rather critically within the scientific community, because they are employed in a highly selective manner. Consequently, over the course of the last three decades, communication scholars from different research traditions have concerned themselves with the question of how single-case information within media content affects audience judgments. Although most publications report exemplification effects of some sort, it remains unclear which types of exemplars are effective and whether they are capable of influencing both perceptual and personal judgments. Applying a multi-level meta-regression approach, we synthesize findings across different studies and investigate potential moderators. Our results suggest overall exemplification effects that seem to be most pronounced for first-level reality judgments, such as public opinion or frequency estimates, but that are limited in their robustness when controlling for interdependence of the measurements.
Phase 1 Safety and Immunogenicity Study of a Respiratory Syncytial Virus Vaccine With an Adenovirus 26 Vector Encoding Prefusion F (Ad26.RSV.preF) in Adults Aged ≥60 Years
Authors: Williams Kristi , Bastian Arangassery Rosemary , Feldman Robert Allen , Omoruyi Edmund , de Paepe Els , Hendriks Jenny , van Zeeburg Hester , Godeaux Olivier , Langedijk Johannes P M , Schuitemaker Hanneke , Sadoff Jerry , Callendret Benoit 
Published: April 2020

Abstract

Background
Despite the high disease burden of respiratory syncytial virus (RSV) in older adults, there is no approved vaccine. We evaluated the experimental RSV vaccine, Ad26.RSV.preF, a replication-incompetent adenovirus 26 vector encoding the F protein stabilized in prefusion conformation.

Methods
This phase 1 clinical trial was performed in healthy adults aged ≥60 years. Seventy-two participants received 1 or 2 intramuscular injections of low-dose (LD; 5 × 1010 vector particles) or high-dose (HD; 1 × 1011 vector particles) Ad26.RSV.preF vaccine or placebo, with approximately 12 months between doses and 2-year follow-up for safety and immunogenicity outcomes.

Results
Solicited adverse events were reported by 44% of vaccine recipients and were transient and mild or moderate in intensity. No serious adverse events were related to vaccination. After the first vaccination, geometric mean titers for RSV-A2 neutralization increased from baseline (432 for LD and 512 for HD vaccine) to day 29 (1031 for LD and 1617 for HD). Pre-F–specific antibody geometric mean titers and median frequencies of F-specific interferon γ–secreting T cells also increased substantially from baseline. These immune responses were still maintained above baseline levels 2 years after immunization and could be boosted with a second immunization at 1 year.

Conclusions
Ad26.RSV.preF (LD and HD) had an acceptable safety profile and elicited sustained humoral and cellular immune responses after a single immunization in older adults.
The Stringent Response Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection Through the Purine Biosynthetic Pathway
Authors: Li Liang , Bayer Arnold S , Cheung Ambrose , Lu Lou , Abdelhady Wessam , Donegan Niles P , Hong Jong-In , Yeaman Michael R , Xiong Yan Q 
Published: April 2020

AbstractPersistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections represent a significant clinical-therapeutic challenge. Of particular concern is antibiotic treatment failure in infections caused by MRSA that are “susceptible” to antibiotic in vitro. In the current study, we investigate specific purine biosynthetic pathways and stringent response mechanism(s) related to this life-threatening syndrome using genetic matched persistent and resolving MRSA clinical bacteremia isolates (PB and RB, respectively), and isogenic MRSA strain sets. We demonstrate that PB isolates (vs RB isolates) have significantly higher (p)ppGpp production, phenol-soluble-modulin expression, polymorphonuclear leukocyte lysis and survival, fibronectin/endothelial cell (EC) adherence, and EC damage. Importantly, an isogenic strain set, including JE2 parental, relP-mutant and relP-complemented strains, translated the above findings into significant outcome differences in an experimental endocarditis model. These observations indicate a significant regulation of purine biosynthesis on stringent response, and suggest the existence of a previously unknown adaptive genetic mechanism in persistent MRSA infection.
Subordinate-State Agency and US Hegemony: Colombian Consent versus Bolivian Dissent
Authors: Kat Quintijn B 
Published: April 2020

AbstractThe strategies of subordinate states in hegemonic or asymmetrical relations have been widely studied by international relations scholars. Such works generally focus on how a subordinate state can influence the hegemon's behavior so as to address and further the interests of the subordinate state. The relation between subordinate-state agency and the hegemonic system, the makeup of the hegemonic order, itself receives less attention. Through analysis of two cases of US hegemony in Latin America, this article examines how subordinate-state agency may strengthen or weaken the hegemonic system and, as such, makes a case for subordinate-state agency as an underpinning element of hegemony. It explores Colombian agency in the design phase of Plan Colombia as contributing to US hegemony, while Bolivian agency under the presidency of Evo Morales is examined as a challenge. In both instances, it was the United States, rather than the Latin American states, that took on a passive role, leaving the initiative with Colombia and Bolivia. Therefore, instead of reaffirmations of active one-way US hegemony versus passive subordinate states, the paper proposes to understand both cases as demonstrating the importance of subordinate-state agency in the configuration of the hegemonic system.