bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jayengan Kampung Permata ditinjau dari kesesuaian terhadap konsep pariwisata berkelanjutan
Authors: Haque Aprillia , Astuti Winny , Mukaromah Hakimatul 
Published: July 2020

<span>Pariwisata merupakan salah satu industri yang memberikan kontribusi besar terhadap perkembangan ekonomi di Indonesia. Namun disisi lain sektor pariwisata merupakan salah satu faktor utama kerusakan lingkungan. Oleh karena itu perlu adanya upaya pengendalian dengan penerapan konsep pariwisata berkelanjutan. Pariwisata berkelanjutan adalah konsep pembangunan yang memperhatikan keseimbangan aspek lingkungan, sosial dan ekonomi. Kota Surakarta memiliki visi sebagai </span><em>Eco-Cultural City</em><span>, visi ini sejalan dengan konsep </span><em>sustainable development </em><span>dan menandakan bahwa Kota Surakarta sudah mulai memperhatikan pentingnya penerapan prinsip pariwisata berkelanjutan. Jayengan Kampung permata adalah sebuah kampung wisata dengan ciri khas industri kerajinan permata. Dalam perkembangannya kampung ini mengalami permasalahan yang menyangkut tentang aspek – aspek keberlanjutan yaitu kegiatan wisata minim partisipasi masyarakat, kurang memperhatikan lingkungan dan belum memberikan dampak ekonomi bagi masyarakat sekitarnya. Untuk itu, tujuan penelitian ini adalah untuk mengetahui kesesuaian Jayengan Kampung Permata terhadap konsep pariwisata berkelanjutan, secara keseluruhan dan berdasarkan pada lima komponen wisata yaitu atraksi, amenitas, infrastruktur, aksesibilitas dan kelembagaan. Metode dalam penelitian ini menggunakan teknik analisis kuantitatif yaitu teknik analisis scoring. Hasil penelitian ini menyatakan bahwa Jayengan Kampung Permata masuk dalam klasifikasi sesuai sebagai kawasan wisata berkelanjutan.</span>
Perhitungan waktu tempuh koridor Jl. Sukarno-Hatta
Authors: Waloejo Budi Sugiarto , Prayitno Gunawan 
Published: July 2020

<span>Tarikan dan bangkitan tata guna lahan, pergerakan antar kota atau antar kawasan pusat kota dengan sub pusat kota, atau subpusat kota dengan subpusat kota lainnya menyebabkan terjadinya penumpukan arus pergerakan lokal yang menyebabkan terjadinya peningkatan waktu tempuh pada ruas jalan.</span><span>Tujuan penelitian ini adalah mengetahui model interaksi tata guna lahan-sistem jaringan jalan di Kawasan Jl. Sukarno-Hatta Kota Malang; mengetahui komponen-komponen yang berpengaruh terhadap penentuan estimasi waktu tempuh; dan menganalisa model hubungan arus lalu lintas dengan penentuan estimasi waktu tempuh. Metode analisis dalam penelitian ini adalah metode deskriptif dengan analisis kualitatif, metode korelasional (metode <em>Pearson Product Moment</em>), dan analisis kuantitatif yang meliputi analisis regresi metode <em>Stepwise</em>, analisis ANOVA, analisis sistem perparkiran, analisis perhitungan kapasitas jalan, analisis tingkat pelayanan jalan. Hasil analisis sensitivitas menunjukkan bahwa rekayasa lalu lintas dapat memperbesar kapasitas ruas jalan terutama yang berada di frontage area guna mencapai tingkat pelayanan jalan ideal. Temuan dari penelitian ini adalah dibutuhkan rasio yang merupakan representasi dari karakteristik pergerakan bangkitan/tarikan tiap-tiap guna lahan pada setiap jamnya. Pengembangan guna lahan campuran (mixed use) yang diharapkan dapat mengurangi pergerakan antar tata guna lahan ternyata menimbulkan pengaruh terhadap peningkatan estimasi waktu tempuh pada ruas jalan tersebut. Komponen yang mempengaruhi estimasi waktu tempuh di Jl. Soekarno Hatta adalah kemacetan dan lama <em>traffic light</em>.</span>
Leakoff and Flowback Experiments on Tight Carbonate Core Plugs
Authors: Tran Son , Habibi Ali , Dehghanpour Hassan , Hazelton Mike , Rose Jeff 
Published: July 2020

Summary
In this paper, we investigate the change in oil effective permeability (koeff) caused by fracturing-fluid (FF) leakoff after hydraulic fracturing (HF) of tight carbonate reservoirs. We perform a series of flooding tests on core plugs with a range of porosity and permeability collected from the Midale tight carbonate formation onshore Canada to simulate FF-leakoff/flowback processes. First, we clean and saturate the plugs with reservoir brine and oil, and age the plugs in the oil for 14 days under reservoir conditions (P = 172 bar and T = 60°C). Then, we measure koeff before (baseline) and after the leakoff process to evaluate the effects of FF properties, shut-in duration, and plug properties on regained permeability values.
We found that adding appropriate surfactants in FF not only significantly reduces koeff impairment caused by leakoff, but also improves koeff compared with the original baseline for a low-permeability carbonate plug. For a plug with relatively high permeability (kair &gt; 0.13 md), freshwater leakoff reduced koeff by 55% (from 1.57 to 0.7 md) while FF (with surfactants) reduced koeff by only 10%. The observed improvement in regained koeff is primarily because of the reduction of interfacial tension (IFT) by the surfactants (from 26.07 to 5.79 mN/m). The contact-angle (CA) measurements before and after the flowback process do not show any significant wettability alteration. The results show that for plugs with kair &gt; 0.13 md, FF leakoff reduces koeff by 5 to 10%, and this range only increases slightly by increasing the shut-in time from 3 to 14 days. However, for the plug with kair &lt; 0.09 md, the regained permeability is even higher than the original koeff before the leakoff process. We observed 28.52 and 64.61% increase in koeff after 3- and 14-day shut-in periods, respectively. This observation is explained by an effective reduction of IFT between the oil and brine in the pore network of the tight plug, which significantly reduces irreducible water saturation (Swirr) and consequently increases koeff. Under such conditions, extending the shut-in time enhances the mixing between invaded FF and oil/brine initially in the plug, leading to more effective reductions in IFT and consequently Swirr. Finally, the results show that the regained permeability strongly depends on the permeability, pore structure, and Swirr of the plugs.
Pertussis outbreak in Southern Ethiopia: challenges of detection, management and response
Authors: Mitiku Aychiluhim Damtew , Argaw Mesele Damte , Desta Binyam Fekadu , Tsegaye Zergu Taffesse , Atsa Afework Ayele , Tefera Bekele Belayihun , Teferi Ephreme , Rogers Deirdre , Beshir Ismael Ali , Gebeyehu Asrat , Anjulo Desta , Abate Derebe Tadesse , Sendeku Agegnehu Gebru , Mulowa Rudzani 
Published: July 2020

Abstract
Background: Despite the availability of effective vaccines, pertussis remains endemic with high fatality rates in low and middle-income countries (LMIC).This study aims to describe an outbreak of pertussis in a health district of Ethiopia. The study highlights the challenges faced by the health system in identifying pertussis cases and appropriately responding to the outbreak at the district level.Methods: A descriptive cross-sectional study was conducted using data sourced from the District Public Health Emergency and Management (PHEM) surveillance service and outbreak management field reports. Stratified attack rates and fatality rates for pertussis are described. Systemic problems leading to the outbreak are explored and narrated. A modified CDC pertussis case definition was employed with a polymerase chain reaction used to confirm cases.Results: From September 2018 to January 2019, 1840 suspected, probable, and confirmed pertussis cases and six deaths were identified. Pertussis cases ranged from 1 month to 51 years in age. An outbreak occurred in 14 out of the 24 villages of Dara Malo district. The overall attack rate was 1708 per 100,000 population with a fatality rate of 3.3 per 1,000 pertussis cases. The highest attack rate of 12,689/100,000 was seen in infants. Among confirmed, probable and suspected pertussis cases, only 41.1% had completed the three-dose pertussis vaccine's primary schedule. The household survey revealed a population coverage of 73.4% and 40.8% for Pentavalent vaccine dose one and three respectively. Investigations suggested the existence of a poor cold chain management system in the study area.Conclusions: There is an urgent need to build capacity to strengthen routine vaccination services and improve the maintenance of the vaccine cold chain. Other LMICs are urged to take lessons learned from this outbreak to strengthen their own vaccination programs and capacitate health workers to manage local outbreaks.
Small intestinal mucosal injury and its risk factors in patients with gastrointestinal cancer who developed complicated fluoropyrimidine-induced diarrhea
Authors: Sakumura Miho , Ando Takayuki , Hosokawa Ayumu , Nakajima Takahiko , Motoo Iori , Mihara Hiroshi , Ueda Akira , Kajiura Shinya , Nanjo Sohachi , Fujinami Haruka , Ogawa Kohei , Yasuda Ichiro 
Published: July 2020

Abstract
Background: Diarrhea is a common adverse event of fluoropyrimidine-based chemotherapy. However, limited data are available on the frequency and risk factors of complicated chemotherapy-induced diarrhea (CID) and small intestinal mucosal damage. In this current study, we aimed to determine the incidence of complicated CID and mucosal injury among patients with complicated CID receiving fluoropyrimidine via small bowel capsule endoscopy (CE) and determined baseline risk factors associated with complicated CID.Methods: In total, 536 patients with advanced or recurrent gastrointestinal cancer who received fluoropyrimidine-based chemotherapy were retrospectively analyzed. Diarrhea was evaluated using the Common Terminology Criteria for Adverse Events version 4. Complicated CID was defined according to the American Society of Clinical Oncology guidelines. To evaluate small intestinal mucosal injury in patients with complicated CID, CE was performed. Multivariate analysis was performed to identify risk factors for complicated CID.Results: Total number of 32 (6%) patients developed complicated CID. Complicating symptoms were noted in 25 (78%) patients, with cramping, vomiting, and sepsis being observed in 15 (60%), 8 (32%), and 3 (12%) patients, respectively. Among the 13 patients who underwent CE, 11 (85%) showed abnormal findings. Multivariate analysis revealed that oral fluoropyrimidine administration was a risk factor for complicated CID (odds ratio, 2.95; 95% confidence interval, 1.06–8.19).Conclusions: Despite the relatively low incidence of complicated CID, mucosal injury of small intestine was common in patients with complicated fluoropyrimidine-induced diarrhea and oral fluoropyrimidine was an independent risk factor.
A qualitative investigation of lived experiences of long-term health condition management with people who are food insecure
Authors: Douglas Flora , MacIver Emma , Yuill Chris 
Published: July 2020

Abstract
Background: As more people are living with one or more chronic health conditions, supporting patients to become activated, self-managers of their conditions has become a key health policy focus both in the UK and internationally. There is also growing evidence in the UK that those with long term health conditions have an increased risk of being food insecure. While international evidence indicates that food insecurity adversely affects individual’s health condition management capability, little is known about how those so affected manage their condition(s) in this context. An investigation of lived experience of health condition management was undertaken with food insecure people living in north east Scotland. The study aimed to explore the challenges facing food insecure people in terms of, i. their self-care condition management practices, and ii. disclosing and discussing the experience of managing their condition with a health care professional, and iii. notions of the support they might wish to receive from them. Methods : Twenty in-depth interviews were conducted with individuals attending a food bank and food pantry in north east Scotland. Interview audio recordings were fully transcribed and thematically analysed.Results : Individuals reporting multiple physical and mental health conditions, took part in the study. Four main themes were identified i.e.: 1. food practices, trade-offs and compromises, that relate to economic constraints and lack of choice; 2. illness experiences and food as they relate to physical and mental ill-health; 3. (in)visibility of participants’ economic vulnerability within health care consultations; and 4. perceptions and expectations of the health care system.Conclusions : This study, the first of its kind in the UK, indicated that participants’ health condition management aspirations were undermined by the experience of food insecurity, and that their health care consultations in were, on the whole, devoid of discussions of those challenges. As such, the study indicated practical and ethical implications for health care policy, practice and research associated with the risk of intervention-generated health inequalities that were suggested by this study. Better understanding is needed about the impact of household food insecurity on existing ill health, wellbeing and health care use across the UK.
The Effects of Mechanical Insufflation-Exsufflation on Lung Function and Complications in Cardiac Surgery Patients: A Pilot Study
Authors: Wu Meng-Fang , Wang Tsai-Yu , Chen Da-Shen , Hsiao Hsiu-Fong , Hu Han-Chuang , Chung Fu-Tsai , Lin Ting-Yu , Lin Shu-Min 
Published: July 2020

Abstract
Background: Postoperative positive pressure lung expansion is associated with decreased pulmonary complications and improved clinical outcomes. The aim of the present study was to compare the differences in post-operative pulmonary complications and clinical outcomes between two groups of study subjects who underwent cardiac surgery; one included subjects who received mechanical insufflation-exsufflation (MI-E) and the other included subjects who received intermittent positive pressure breathing (IPPB) therapy. Methods: This retrospective study included 51 subjects, who underwent cardiac surgery in an intensive care unit of a tertiary hospital during the time period from June 2017 to February 2018. After liberation from mechanical ventilation, the subjects received lung expansion therapy by means of two types of positive pressure devices, MI-E (n=21) or IPPB (n=30). The pulmonary complications, lung function, and clinical outcomes were compared between the two groups. Results: Subjects in both groups displayed similar baseline characteristics and underwent similar types of surgical procedures. Compared to subjects who received non-oscillatory therapy, those who received MI-E therapy had higher post-operative force vital capacity (58.4±4.74 % vs. 46.0±3.70 %, p=0.042), forced expiratory volume in one second (62.4±5.23 % vs. 46.8±3.83 %, p=0.017), and peak flow rate (67.1±5.53 L vs. 55.7±4.44 L p=0.111). However, the incidence of chest pain was higher in the MI-E group (n=13, 61.9%) than in the IPPB group (n=4, 16.7%; odds ratio, 0.123, 95% confidence interval, 0.03-0.45; p=0.002). The length of hospital and ICU stay, development of atelectasis, pneumonia, and pleural effusion were similar in both the groups. Conclusion : Both IPPB and MI-E therapies have similar effects on preventing post-operative complications in cardiac surgery patients. However, compared to IPPB therapy, MI-E therapy was associated with better-preserved pulmonary function and higher incidence of chest pain.
LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis
Authors: Tian Jun , Cui Peng , Li Yifei , Yao Xuequan , Wu Xiaoyu , Wang Zhirong , Li Chunsheng 
Published: July 2020

Abstract
Background LncRNAs have been demonstrated to be functional regulators in tumor progression through interaction with various signaling pathways in multiple cancer types. However, the effect of LINC02418 on CRC progression still remains unclear. Methods LncRNA expression profile in CRC tissues was explored by using the TCGA database. The expressional level of LINC02418 in CRC patients was confirmed by qRT-PCR. Kaplan-Meier analyses was used to investigate the correlations between LINC02418 and OS of patients with CRC. After stably transducing sh-LINC02418 and sh-NC into HCT116 and LoVo cells, cell proliferative, migratory and invasive abilities were detected by CCK-8 assay, colony formation assay and trans-well assay, respectively. The binding between LINC02418 and miR-34b-5p, and the interaction between miR-34b-5p and BCL2 were determined by dual-luciferase assay. Western blot experiments were conducted to further explore the effect of miR-34b-5p on BCL2 signaling pathway. Rescue experiments were performed to uncover the role of LINC02418 /miR-34b-5p/ BCL2 axis in CRC progression. Results LINC02418 was upregulated in human colon cancer samples and its high expression correlated with poor prognosis. LINC02418 promoted cancer progression by enhancing tumor growth, cell mobility and invasiveness of colon cancer cells. Additionally, LINC02418 could physically bind to miR-34b-5p and subsequently interact with BCL2 signaling pathway. Down-regulation of LINC02418 reduced cell proliferation, but transfection of miR-34b-5p inhibitor or BCL2 in LINC02418-silenced colon cancer cells significantly promoted cell growth. Conclusions LINC02418 was upregulated in human colon cancer samples and could be used as indicator for prediction of prognosis. LINC02418 acted as a tumor driver by negatively regulating cell apoptosis through LINC02418 /miR-34b-5p/ BCL2 axis and in colorectal cancer.
Evaluation of toxoplasmosis in pregnant women using dot-immunogold-silver staining with recombinant Toxoplasma gondii peroxiredoxin protein
Authors: Liu Zhuan-Zhuan , Li Xue-Yan , Fu Lin-Lin , Yuan Fei , Tang Ren-Xian , Liu Yi-Sheng , Zheng Kui-Yang 
Published: July 2020

Abstract
Background: Toxoplasma gondii infection endangers human health and affects animal husbandry. Serological detection is the main method used for epidemiological investigations and diagnosis of toxoplasmosis. The key to effective diagnosis of toxoplasmosis is the use of a standardized antigen and a specific and sensitive detection method. Peroxiredoxin is an antigenic protein and vaccine candidate antigen of T. gondii that has not yet been exploited for diagnostic application. Methods: In this study, recombinant T. gondii peroxiredoxin protein (rTgPrx) was prepared and used in dot-immunogold-silver staining (Dot-IGSS) to detect IgG antibodies in serum from mice and pregnant women. The rTgPrx-Dot-IGSS method was established and optimized using mouse serum. Furthermore, serum samples from pregnant women were analyzed by rTgPrx-Dot-IGSS.Results: Forty serum samples from mice infected with T. gondii and twenty negative serum samples were analyzed. The sensitivity and specificity of rTgPrx-Dot-IGSS were 97.5% and 100%, respectively, equivalent to those of a commercial ELISA kit for anti-Toxoplasma IgG antibody. Furthermore, 540 serum samples from pregnant women were screened with a commercial ELISA kit. Eighty-three positive and 60 negative serum samples were analyzed by rTgPrx-Dot-IGSS. The positive rate was 95.18%, comparable to that obtained with the commercial ELISA kit.Conclusions: The Dot-IGSS method with rTgPrx as an antigen might be useful for diagnosing T. gondii infection in individuals.
Evidence of vector borne transmission of Salmonella enterica subsp. enterica ser. Gallinarum and fowl typhoid mediated by the poultry red mite, Dermanyssus gallinae (De Geer, 1778)
Authors: Cocciolo Giulio , Circella Elena , Pugliese Nicola , Lupini Caterina , Mescolini Giulia , Catelli Elena , Borchert-Stuhlträger Monika , Zoller Harmut , Thomas Emmanuel , Camarda Antonio 
Published: July 2020

Abstract
Background: The poultry red mite Dermanyssus gallinae (De Geer 1778) is a major ectoparasite of poultry. Infestations are found in most laying hen farms in Europe, and breeder flocks have also been reported to be affected. Mite infestation has detrimental effects on animal welfare, are a cause of significant economic losses, and D. gallinae is often considered as a pathogen vector. Despite suspicion of a close relationship between the poultry red mite and Salmonella enterica subsp. enterica ser. Gallinarum biovar Gallinarum ( S. Gallinarum), the causative agent of fowl typhoid (FT), there has been no definitive proof of mite-mediated transmission. Therefore, an investigation was conducted to determine if D. gallinae -mediated transmission of S. Gallinarum could be demonstrated among four different hen groups.Methods: Two groups of 8 hens (A and B) were experimentally infected with S. Gallinarum in two isolators. After seven days, when birds showed signs of FT, about 25,000 mites were introduced. After 3 days, mites were harvested and used to infest other two hen groups of 8 (C and D), in two separate isolators. Health status of hens was constantly monitored; detection and quantification of S. Gallinarum were performed by PCR and qPCR from mites and organs of dead hens. The maximum likelihood estimation of the infection rate and mite vectorial capacity were calculated.Results: Clinical disease was observed in groups infected with S. Gallinarum (A and B) and in hens of groups C and D infested with mites harvested from the isolators containing groups A and B. In all 4 groups, S. Gallinarum was detected from liver, spleen, ovary and cecum of hens, thus confirming the diagnosis of FT. Mite analysis demonstrated the presence of the pathogen, with an estimated infection rate ranging between 13.72 and 55.21 infected per thousand mites. Vectorial capacity was estimated to be 73.79.Conclusion: Mites harvested from birds infected with S. Gallinarum were shown to carry the mite, and then to transfer S . Gallinarum to isolated groups of pathogen-free birds that subsequently showed signs of FT. Mite vectorial capacity was high, demonstrating that D. gallinae should be considered an effective vector of FT.
Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
Authors: Liu Wenhui , La A La Teng Zhu , Evans Alexander , Gao Shengtao , Yu Zhongtang , Bu Dengpan , Ma Lu 
Published: July 2020

Abstract
Background: There is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic growth promoters in animal production. This study was conducted to evaluate the effects of supplementation of sodium butyrate (SB) in milk and/or milk replacer on the growth performance, rumen fermentation, and serum antioxidant capacity and immunoglobins in dairy calves before weaning. Forty healthy female Holstein calves (4-day-old; 40 ± 5 kg of body weight) were housed in individual hutches and randomly allocated to 1 of 4 treatment groups (n = 10 per group). The control group was fed no SB (SB0), while the other three groups were supplemented with 15 (SB15), 30 (SB30), or 45 (SB45) g per day of SB mixed into milk and/or milk replacer. Results: The SB supplementation enhanced growth and improved feed conversion into body weight gain compared with the SB0 group. No significant effect on rumen pH; concentrations of NH3-N, individual and total VFAs; or acetate: propionate (A:P) ratio was found during the whole experimental period. The serum glutathione peroxidase activity was higher in the SB30 and SB45 groups compared with the SB0 group, and the serum level of maleic dialdehyde linearly decreased as the SB supplementation amount increased during the whole experiment. Not inﬂuence of SB supplementation was observed on serum concentrations of immunoglobulin A, immunoglobulin G, or immunoglobulin M during the whole experimental period. Conclusions: Under the conditions of this study, SB supplementation improved growth performance and antioxidant ability in pre-weaned dairy calves. We recommended 45 g per day as the optimal level of SB supplementation (mixed into milk and/or milk replacer) to improve the growth and antioxidant function of dairy calves before weaning.