bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal and climatic variation in the incidence of adult acute appendicitis: a seven year longitudinal analysis
Authors: York Thomas James 
Published: April 2020

Abstract
Background
Acute appendicitis represents an extremely common surgical emergency, yet its aetiology remains uncertain. A multifactorial understanding of its causation has emerged along with increasing evidence of seasonal variation.
This study seeks to find evidence for such a circannual trend within the United Kingdom (UK), and further assess key meteorological indicators which may be causative of any such variation.

Methods
The patient records of a region health body in the North East of England were retrospectively assessed over a 7-year period. The incident cases of acute appendicitis were recorded and averaged by month before undergoing statistical analysis for variation and correlation with average temperature, sunlight hours, and rainfall.

Results
The incidence of acute appendicitis revealed significant seasonal variation with only 38 incident cases in the months of January compared to 73 in July, a 92.1% increase.
Only a weak correlation was seen between incidence and average sunlight hours/rainfall, however a significant, positive correlation was found between incidence and average temperature (r = 0.58, p = 0.048).

Conclusion
Compelling evidence is found to support the existence of a circannual trend for acute appendicitis. Data suggests a seasonal peak in the month of July, accompanied by a low in January, a finding that develops the understanding of this trend from previously equivocal research in the UK.
A clear correlation is also established between the incidence of acute appendicitis and average temperature. The 92.1% increase between the coolest and warmest months suggests a greater magnitude for this as a risk factor than has previously been shown.
A comprehensive Chinese experience against SARS-CoV-2 in ophthalmology
Authors: Yu A-Yong , Tu Ruixue , Shao Xu , Pan Anpeng , Zhou Kaijing , Huang Jinhai 
Published: April 2020

AbstractThe 2019 novel coronavirus disease (COVID-19) has now swept through the continents and poses a global threat to public health. Several investigations have been conducted to identify whether COVID-19 can be transmitted through the ocular route, and the conclusion is that it is a potential route but remains uncertain. Due to the face-to-face communication with patients, frequent exposure to tears and ocular discharge, and the unavoidable use of equipment which requires close proximity, ophthalmologists carry a high risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on 33 articles published by Chinese scholars, guidelines and clinical practice experience in domestic hospitals, we have summarized the Chinese experience through the lens of ophthalmology, hoping to make a contribution to protecting ophthalmologists and patients around the world.
A review on process-oriented approaches for analyzing novice solutions to programming problems
Authors: Villamor Maureen M. 
Published: April 2020

AbstractHigh attrition and dropout rates are common in introductory programming courses. One of the reasons students drop out is loss of motivation due to the lack of feedback and proper assessment of their progress. Hence, a process-oriented approach is needed in assessing programming progress, which entails examining and measuring students’ compilation behaviors and source codes. This paper reviews the elements of a process-oriented approach including previous studies that have used this approach. Specific metrics covered are Jadud’s Error Quotient, the Watwin Score, Probabilistic Distance to Solution, Normalized Programming State Model, and the Repeated Error Density.
Theophrastus on Perceiving
Authors: Caston Victor 
Published: April 2020

AbstractMany fragments from Theophrastus on perception are preserved by the late Neoplatonist, Priscian of Lydia. After preliminary source criticism concerning how to identify the fragments, I turn to Theophrastus’ discussion of perceiving and perceptual awareness. While he clearly rejects literalism, he also does not embrace “spiritualism”: he argues instead that we receive the defining proportions of perceptible qualities in the sense organ, though in different contraries than in the perceptible (thereby avoiding literalism). If Priscian’s report is faithful, Theophrastus also accepts a moderate capacity reading ofDe animaIII.2, locating awareness in a central monitoring sense, common to the individual modalities; and this has further implications for the unity of consciousness. Theophrastus’ method, though aporetic in form, is nonetheless a constructive engagement with the same texts of Aristotle’s we have ourselves, in the service of a joint research program in psychology that he shared with his colleague and former teacher.
ЗВ’ЯЗОК ЗАДОВОЛЕНОСТІ ЖИТТЯМ ЗІ СТАВЛЕННЯМ ДО ГРОШЕЙ У ОСІБ ЮНАЦЬКОГО ВІКУ
Authors: Власова-Чмерук Оксана , Юдко Аліна 
Published: April 2020

Питання про те, наскільки переживання задоволеності життям, відчуття щастя може бути пов’язане з достатком, фінансовим благополуччям людини, здавна є предметом наукових розвідок для еко­но­­містів, соціологів та психологів. Актуальність досліджень цієї теми пов’язана зі змінами монетарних цін­ностей сучасної молоді. В статті представлені результати емпіричного дослідження зв’язку задо­воленості життям зі ставленням до грошей у молоді. Описано процедуру дослідження з використанням чотирьох методик: тесту «Індекс задоволеності життям» в адаптації Н. В. Паніної; тесту «Діагностика задоволеності життям» А. Б. Білоусової; опитувальника «Суб’єктивне економічне благополуччя» В. А. Ха­щен­ко; методики «Шкала грошових уявлень та поведінки» в модифікації М. В. Сімків. За результатами емпі­ричного дослідження встановлено, що негативні установки щодо грошей (грошова одержимість, неадекватне поодження з грошима, сприйняття грошей як інструменту влади і впливу) погіршують емоційний компонент задоволеності життям (настрій), знижують задоволеність життям у сфері кохан­ня. Економічний оптимізм, спокійне і зважене ставлення до грошей, відчуття того, що власний достаток відповідає власним потребам, допомагає людині відчувати задоволеність від життя в аспектах: вміння насолоджуватися відпочинком, задоволення від високої динаміки життя. Економічний оптимізм також дозволяє відчувати задоволення від досягнення поставлених цілей. Результати дослідження дозволяють наголосити на важливості розробки спеціальних програм для розвитку фінансової грамотності, своє­час­ного формування позитивних установок щодо грошей підлітків та юнаків
ФУНКЦІЇ НАРЦИСИЧНОЇ САМОРЕГУЛЯЦІЇ У КОНТЕКСТІ ОСОБИСТІСНОГО САМОЗДІЙСНЕННЯ
Authors: Клименко Марія 
Published: April 2020

У статті теоретично обґрунтовано та емпірично встановлено зв’язок нарцисичної саморегуляції та особистісного самоздійснення. Нарцисична саморегуляція – це механізм саморегуляції психодинамічного типу, що дбає про стабільність та цілісність Self-системи, позитивне сприймання себе, здорову самоцін­ність та самоповагу. Конкретизовано, що особистісна самоцінність – це умова відкритості до екзистен­ційних цінностей, які пропонує життя; змога обрати та наважитися реалізовувати власний життєвий вибір; готовність дбати про особистий сенс існування. Нарцисична саморегуляція скерована на забез­пе­чення потреб безпеки та повноцінного функціонування у соціальному середовищі; пошук та підтримання ціннісних орієнтирів, увінчуючи все потребами вести більш наповнене, осмислене життя, яке не фік­сується лиш на самоствердженні, а розкриватиме себе у сповненості.
Зафіксовано, що загальний показник самоздійснення (сповненості) перебуває у зв’язку майже з усі­ма показниками функціонування нарцисичної саморегуляції, зокрема рівнем нарцисизму та індексом функ­ціо­­нування системи Self. Виявлено, що особи з вищими показниками сповненості характеризуються більш наближеними значеннями індексу функціонування загальної системи Self до значень ідеально сильного Self при зростанні рівня нарцисизму. Натомість підвищений рівень нарцисизму не виключає того, що само­ре­гу­ляція виконує свою функцію навіть краще, ніж при рівні нижчому. Тож емпірично підтверджено, що від­чут­тя власної цінності може бути однією з важливих умов формування екзистенційної відкритості до світу.
Статистично проаналізовано чинники сповненості, що лежать в основі функціонування нар­цисич­ної саморегуляції, та виявлено, що ними є: сила Self, значущість Self, наявність особистісного ідеалу само­достатності, низька схильність до знецінювання інших людей, менш актуальне прагнення похвали та отри­мання нарцисичної вигоди від захворювання, потреба в ідеальному Self-об’єкті, помірно виражена потреба в іпохондричному захисті від тривоги. Отже, підтверджено, що нарцисична саморегуляція причетна до задоволення потреби у сенсі життя, оцінки життєвого досвіду як більш наповненого змістом
A Damping Modification Factor Prediction Model for Horizontal Displacement Spectrum from Subduction Interface Earthquakes in Japan Accounting for Site Conditions
Authors: Zhou Jun , Zhao John X. 
Published: April 2020

ABSTRACT
This article presents a damping modification factor (DMF) model without source and path parameters for subduction interface earthquakes in Japan using a similar dataset as the one used in the Zhao, Liang, et al. (2016) study. Site effect was modeled by site classes based on site periods. DMF models were constructed using the spectra for 13 damping ratios at 34 spectral periods. The DMF values can be calculated in a damping ratio range of 1%–30% and in a spectral period range of 0.03–5.0 s. The effect of damping ratios was modeled by a simple quadratic function of the damping ratios in the logarithm scale, and the effect of the spectral period was modeled by a simple fourth-order polynomial of the spectral period also in the logarithm scale. The DMF value is 1.0 at a spectral period of ≤0.02  s . At long periods &gt;5.0  s, the DMFs for different damping ratios appear to converge to 1.0, satisfying the condition of constant displacement spectrum at long periods. For an extrapolation to &gt;5.0  s for a damping ratio &lt;5%, DMF=1.0 can be selected when DMF&lt;1.0; for a damping ratio &gt;5%, DMF=1.0 can be selected when DMF&gt;1.0. For a damping ratio &lt;5%, all standard deviations decrease linearly with increasing damping ratios in the logarithm scale; for a damping ratio &gt;5%, all standard deviations increase linearly with increasing damping ratios in the logarithm scale. A smoothed displacement spectrum useful for engineering designs can be obtained by scaling the spectrum from Zhao, Liang, et al. (2016). The DMF values from this study are close to those of the published models at some spectral periods. The residual distribution suggests that DMFs are functions of earthquake source and path parameters.
Increase in the folate level can decrease the intensity of disorder in patients with depression who use citalopram: a randomized clinical trial
Authors: Morovati Masume , Morsali Yousef , Rezaee Saeed , Pezeshki Ayoub , Esmaeilzadeh Abdolreza , Ranjbar Hadi , Islambulchilar Mina 
Published: April 2020

Abstract
Background Depression is one of the most common mental health disorders, which affiliated more than four percent of world population. Several antidepressant agents, including citalopram were developed. High dose and long-term treatment with these agents along with their side effects decrease the treatment adherence. Using supplements such as acid folic is a way to increase these drug’s efficacy. The aim of this study was to assess the effect of acid folic supplement and increase in blood folate level of the intensity of depression symptoms.Methods This was a randomized-controlled clinical trial. Twenty-four patients with major depression were randomly assigned to two groups. Both groups received citalopram as their standard treatment. The intervention group received acid folic supplement (1mg/daily). The folate levels of blood, Beck's depression inventory and Hamilton depression scale scores were measured. The measurements were conducted before intervention, and in 45 and 90 days follow ups. Data were analyzed using Mann-Whitney U and Friedman tests.Results The blood level of folate was increased for the intervention group. The Hamilton depression scale and Beck Depression Inventory Scores were reduced significantly in both groups after 90 days follow up. There were no significant differences between two groups in the reduction of depression scores. In the intervention group, the decrease of Hamilton's depression scale score was negatively correlated to the increase of blood folate level.Conclusions The increase in blood folate level may be correlate with the decrease in depression symptoms. The use of 1mg/d supplement of acid folic was not effective in the reduction of depression symptoms in patients with major depression.Registered in Iranian Registry of Clinical Trials (IRCT20180115038373N1)
MIR17HG polymorphisms contribute to High altitude pulmonary edema susceptibility in Chinese Han people
Authors: Zhao Yanli , Si Lining , Long Qifu , Zhu Derui , Shen Guoping , Wang Rong 
Published: April 2020

Abstract
Background: High altitude pulmonary edema (HAPE) is a severe form of acute mountain sickness (AMS). The results of existing studies have shown that the onset of HAPE has obvious ethnic specificity and personal susceptibility, suggesting that the occurrence of HAPE is related to genetic factors. Therefore, six polymorphisms on MIR17HG were selected to investigate the effect of mutations on MIR17HG on HAPE in Chinese Han population.Materials and Methods: 487 healthy participants (244 participants had high altitude pulmonary edema, as the case group; and 243 participants had no symptoms of HAPE, as the control group) were genotyped via the Agena MassARRAY, and the relationship between polymorphisms on MIR17HG and HAPE risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.Results: In the allele model, we observed that lower risk (OR = 0.74, 95%CI: 0.56 - 0.98, p = 0.036) of the A allele for rs7318578 on the MIR17HG compared with the people with the C allele. Logistic regression analysis of four models for all selected MIR17HG SNPs between cases and controls showed significant differences for rs7318578 (OR = 0.74, 95%CI: 0.56 – 0.98, p = 0.037) and rs17735387 (OR = 1.51, 95%CI: 1.03 – 2.21, p = 0.036) in the HAPE population.Conclusion: rs7318578 and rs17735387 on MIR17HG were associated with the genetic susceptibility of HAPE in Chinese Han population.
Comparison of clinical effects of two brands of toric intraocular lens
Authors: Liu Yinan , Wu Qianru , Cai Hongyuan , Chen Xiaoyong 
Published: April 2020

Abstract
Background This study aimed to compare the clinical effects of two brands of toric intraocular lens used in surgical correction of cataract with corneal astigmatism. Methods 35 patients (50 eyes) with corneal astigmatism who underwent ophthalmic surgery from April 2019 to July 2019 were retrospectively analyzed. Among them, 25 eyes of 20 patients were implanted with Rayner 623T, while 25 eyes of 15 patients with Alcon AcrySof Toric intraocular lens (IOL). Three months after surgery, the uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), residual astigmatism, rotational degree of intraocular lens, contrast sensitivity, objective visual quality and the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) scale score were compared. Results The mean postoperative UCDVA (logMAR) and BCDVA (logMAR) in the Rayner group were 0.17 ± 0.20 and 0.08 ± 0.15, respectively (P > 0.05), while those in the Alcon group were 0.21 ± 0.16 and 0.10 ± 0.11, respectively (P > 0.05). The mean residual astigmatism in the Rayner group was (0.69±0.40) while that in the Alcon group was (0.62±0.49), (P >0.05). There was no statistically significant difference between the two groups in IOL rotational stability, contrast sensitivity and objective visual quality (P > 0.05). The NEI VFQ-25 scale score was 85.16±5.91 in the Rayner group while that was 82.08±6.16 in the Alcon group, (P > 0.05). Conclusions The two brands of toric intraocular lens- Rayner 623T and Alcon AcrySof Toric showed no significant difference in their clinical effects.
Abdominal obesity phenotypes outcomes: protocol for a systematic review
Authors: Doustmohamdian Soraya , Hosseinpanah Farhad , Momeni Marjan 
Published: April 2020

Abstract
Background: The prevalence of obesity is increasing in the worldwide. Obesity is associated with serious health effects. Abdominal obesity has a stronger association with metabolic dysfunction.Methods: We will search PubMed/MEDLINE, EMBASE, Web of Science, Cochrane Library, and ProQuest (from inception onwards). Additional studies will be identified through manual searching of reference lists. Quantitative studies evaluating the abdominal obesity phenotypes outcomes in adult will be included. Main outcomes will be assay the abdominal obesity phenotypes outcomes included risk of DM2, cardiovascular and all cause mortality. Two reviewers will independently screen full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using appropriate tools. If feasible, we will conduct random effects meta-analysis. The two researchers also will be assessed the quality of the articles independently based on CASP.Discussion: This systematic review will summarize the evidence regarding the association between abdominal obesity phenotypes and DM2, cardiovascular disease and all cause mortality. The results of this review will provide a useful reference for importance of abdominal obesity on metabolic dysfunction and mortality.Systematic review registration: International Prospective Register of Systematic Reviews PROSPERO.The protocol of the systematic review was drafted and uploaded to PROSPERO website. (PROSPERO CRD42019111056).
Irisin recovers osteoarthritic chondrocytes: a muscle-cartilage cross-talk boosted by physical activity
Authors: Vadalà Gianluca , Giacomo Giuseppina Di , Ambrosio Luca , Cannata Francesca , Cicione Claudia , Papalia Rocco , Denaro Vincenzo 
Published: April 2020

Abstract
Background Physical exercise favors weight loss and ameliorates both articular pain and function in patients suffering from osteoarthritis (OA). Irisin, a myokine released by skeletal muscles upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. The study aimed to investigate the effect of irisin on human osteoarthritic chondrocytes (hOAC) in vitro . The hypothesis of this study was that irisin would improve hOAC metabolism and proliferation. Methods hOAC were isolated from osteochondral tissues of 5 patients undergoing total knee joint replacement. Cells were cultured in growing media and then exposed to either phosphate-buffered saline (control group) or human recombinant irisin (experimental group). Cell proliferation (Picogreen assay), glycosaminoglycan content (dimethylmethylene blue), type II/X collagen gene expression (Real-Time polymerase chain reaction) and quantification (Western blot and densitometric analysis), p38/ERK MAPK and Akt involvement (Western blot and densitometric analysis) were evaluated in both groups. Results Irisin increased hOAC proliferation ( p < 0.001) and both type II collagen gene expression ( p < 0.001) and protein levels ( p < 0.01), while decreased type X collagen gene expression ( p < 0.05) and protein levels ( p < 0.001). These effects seemed to be mediated by the inactivation of the p38 MAPK and PI3K-Akt intracellular pathways, as irisin reduced phosphorylated p38 (p-p38), ( p < 0.01) and phosphorylated Akt (p-Akt) ( p < 0.001) protein levels. Conclusion Irisin stimulated cell proliferation and anabolism in hOAC through p38 MAPK and PI3K-Akt inactivation in vitro , demonstrating for the first time the existence of a cross-talk between muscle and cartilage.
Danube water quality and assessment on ecotourism in the biosphere reserve ‘Bačko Podunavlje’ in Serbia
Authors: Obradović Sanja , Pantelić Milana , Stojanović Vladimir , Tešin Aleksandra , Dolinaj Dragan 
Published: April 2020

Abstract
‘Bačko Podunavlje’ represents one of the largest and the best-preserved wetland areas of the upper Danube. Water quality is crucial for nature in protected areas and ecotourism. The paper is based on data for the period 1992–2016. Using multivariate statistical analysis, water quality was defined. One-factor analysis of variations is the starting point for the analysis of time variables (annual and monthly analysis). The principal component analysis (PCA) of the ten quality parameters is in the three factors that determine the greatest impact on the change in water quality. Results revealed the satisfactory ecological status of the Danube River in these sections (Bezdan and Bogojevo) and there is no threat that the biodiversity of this area is endangered by poor water quality, which fully justifies the possibilities for intensive development of ecotourism in the biosphere reserve. Suspended solids are the only parameter that exceeds the allowed limit values in a larger number of measurements, especially in the summer period of the year. Other analyzed water quality parameters range within the allowed limit values for the second class of surface water quality based on the Law on Waters (Republic of Serbia) and in accordance with the Water Quality Classification Criteria of ICPDR.
PORTUGUESES E BRASILEIROS NA UNIVERSIDADE PORTUGUESA: aspectos sobre acesso e permanência
Authors: Vargas Hustana Maria , Silva Amanda Gonçalves da 
Published: April 2020

Entrevista com o professor João Miguel Teixeira Lopes, sociólogo, professor catedrático de Sociologia da Universidade do Porto, em Portugal. No âmbito do ensino superior, participou de pesquisas como: “Os Estudantes e seus Trajectos no Ensino Superior: sucesso e insucesso, factores e processos, promoção de boas práticas” e do “Observatório dos Estudantes de Sociologia”. Na mesma área, publicou as seguintes obras: “Percurso de Estudantes no Ensino Superior”, “Factores, Representações e Práticas Institucionais de promoção de Sucesso Escolar no Ensino Superior”, “Desigualdades plurais no Ensino Superior” e “Desigualdades de percurso no Ensino Superior”.