bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraining dark photon properties with Asteroseismology
Authors: Ayala Adrián , Lopes Ilidio , García Hernández Antonio , Suárez Juan Carlos , Muñoz Elorza Íñigo 
Published: October 2019

ABSTRACT
Dark photons are particles invoked in some extensions of the Standard Model that could account for at least part of the dark matter content of the Universe. It has been proposed that the production of dark photons in stellar interiors could happen at a rate that depends on both, the dark photon mass and its coupling to Standard Model particles (the kinetic mixing parameter χ). In this work, we aim at exploring the impact of dark photon productions in the stellar core of solar mass red giant branch (RGB) stars during late evolutionary phases. We demonstrate that near the so-called RGB bump, dark photons production may be an energy sink for the star sufficiently significative to modify the extension of the star convective zones. We show that Asteroseismology is able to detect such variations in the structure, allowing us to predict an upper limit of $\rm 900\ eV$ and 5 × 10−15 for the mass and kinetic mixing of the dark photons, respectively. We also demonstrate that additional constraints can be derived from the fact that dark photons increase the luminosity of the RGB tip over the current observational uncertainties. This work thus paves the way for an empirical approach to deepen the study of such dark matter particles.
Chemical abundances of open clusters from high-resolution infrared spectra – II. NGC 752
Authors: Böcek Topcu G , Afşar M , Sneden C , Pilachowski C A , Denissenkov P A , VandenBerg D A , Wright D , Mace G N , Jaffe D T , Strickland E , Kim H , Sokal K R 
Published: October 2019

ABSTRACTWe present a detailed near-infrared chemical abundance analysis of 10 red giant members of the Galactic open cluster NGC 752. High-resolution (R ≃ 45000) near-infrared spectral data were gathered with the Immersion Grating Infrared Spectrograph, providing simultaneous coverage of the complete H and K bands. We derived the abundances of H-burning (C, N, O), α (Mg, Si, S, Ca), light odd-Z (Na, Al, P, K), Fe-group (Sc, Ti, Cr, Fe, Co, Ni), and neutron-capture (Ce, Nd, Yb) elements. We report the abundances of S, P, K, Ce, and Yb in NGC 752 for the first time. Our analysis yields solar-metallicity and solar abundance ratios for almost all of the elements heavier than the CNO group in NGC 752. O and N abundances were measured from a number of OH and CN features in the H band, and C abundances were determined mainly from CO molecular lines in the K band. High-excitation $\rm{C\,\small {I}}$ lines present in both near-infrared and optical spectra were also included in the C abundance determinations. Carbon isotopic ratios were derived from the R-branch band heads of first overtone (2−0) and (3−1) 12CO and (2−0) 13CO lines near 23 440 Å and (3−1) 13CO lines at about 23 730 Å. The CNO abundances and 12C/13C ratios are all consistent with our giants having completed ‘first dredge-up’ envelope mixing of CN-cyle products. We independently assessed NGC 752 stellar membership from Gaia astrometry, leading to a new colour–magnitude diagram for this cluster. Applications of Victoria isochrones and MESA models to these data yield an updated NGC 752 cluster age (1.52 Gyr) and evolutionary stage indications for the programme stars. The photometric evidence and spectroscopic light element abundances all suggest that the most, perhaps all of the programme stars are members of the helium-burning red clump in this cluster.
Glomerular endothelial activation, C4d deposits and microangiopathy in immunoglobulin A nephropathy
Authors: Trimarchi Hernán , Coppo Rosanna 
Published: October 2019

AbstractImmunoglobulin A nephropathy (IgAN) is considered as mesangiopathy since it initiates in the mesangium; however, other glomerular components are involved and the glomerular capillary wall offers the first contact to circulating macromolecular IgA1. Acute and active forms of IgAN are associated with endocapillary hypercellularity and vascular damage of various degrees, in severe cases with microangiopathy (MA) without or with thrombosis [thrombotic microangiopathy (TMA)]. Vascular damage activates complement and coagulation cascades. A defective complement regulation has recently been detected in active and progressive cases of IgAN. C4d deposits in renal biopsies have been found to be an early risk factor. These observations have raised interest in manifestation of MA and TMA in progressive cases of IgAN. MA–TMA lesions have been found in various percentages (2–53%) of patients with IgAN according to patients’ selection and pathology definition of TMA. The association with hypertension (HTN) was so strong that it led to the hypothesis that MA/TMA in IgAN was a mere consequence of severe HTN. Old and new clinical and experimental data indicate that in IgAN the interaction of the glomerular capillary wall with immune reactants and complement uncontrolled activation leading to C4b deposits favours the development of MA–TMA, which plays a role in progression and renal function decline. The central role of complement activation is relevant also for the new therapeutic interventions offered by the pharma.
Occupational Exposure to the Ugandan Research Strain (MR766) of Zika Virus
Authors: Lichtenberger Paola N , Ricciardi Michael J , Solorzano Dalhila , Raccamarich Patricia , Leda Ana , Sharkey Mark , Watkins David I , El Sahly Hana , Rouphael Nadine , Mulligan Mark J , Doblecki-Lewis Susanne , Stevenson Mario , Alcaide Maria L 
Published: October 2019

Abstract
A laboratory worker suffered an accidental needle-stick resulting in an exposure to the Ugandan strain (MR766) of Zika virus, which has rarely been studied in humans. We report the clinical presentation and outcomes, molecular and serological diagnostic results, and antibody response.
The Name of God in a Constitution: Meaning, Democracy, and Political Solidarity
Authors: Deagon Alex 
Published: October 2019

Abstract
This article explores the idea that recognizing God in the Constitution of a modern liberal democracy benefits both religious and non-religious citizens through symbolizing transcendent meaning and facilitating political solidarity. It first argues that pure autonomous reason is not sufficient to support these benefits and any attempt to ‘translate’ the religious principles into secular ones will diminish the benefits for religious citizens. Second, recognizing God in a Constitution does not necessarily impose a religious character, belief, or practice which is detrimental to non-religious citizens. Rather, recognition alludes to a shared heritage and tradition and acknowledges that religious individuals and groups are legitimately part of and interact with the modern democratic state. Finally, and most importantly, recognition of God as a broader symbolic recognition of religion can enhance the democratic process by motivating virtuous conduct and opening up the political space to higher levels of meaning and the good.
Hazards of Our Helping Profession: A Practical Self-Care Model for Community Practice
Authors: Brown Mary-Ellen 
Published: October 2019

AbstractThe social work profession is a helping profession; social workers provide services with the intent to improve life opportunities in pursuit of social justice for individuals, groups, communities, and society as a whole. Social workers are called to work on behalf of the most vulnerable people in our society, and as such, the hazards of our helping profession are abundant. Though the literature offers numerous frameworks that can be used by social workers in a variety of settings, many issues that are unique to community practice settings can lead to professional burnout and compassion fatigue for social workers. At present there are no comprehensive models for self-care that attend specifically to the unique needs of the community practitioner. This article presents the iM-PAACT model, a four-part conceptual framework that helps to fill this gap in the literature. This practical self-care model has been designed specifically for social workers engaged primarily in community practice settings, including the community activist, community organizer, and community-engaged scholar.
Serum Zinc, Selenium and Total Antioxidant Contents of Nigerian Children with Asthma: Association with Disease Severity and Symptoms Control
Authors: Kuti Bankole Peter , Kuti Demilade Kehinde , Smith Olufemi Samuel 
Published: October 2019

AbstractBackgroundMicronutrients and antioxidants may ameliorate oxidative stress. This study aimed to determine the serum Zinc (Zn), Selenium (Se) and Total Antioxidant Contents (TAC) of Nigerian children with asthma and relate these to disease severity and symptoms controlMethodsChildren aged 2–15 years with asthma and age and sex matched controls were consecutively recruited. The children’s serum Zn, Se and TAC were assayed and compared.ResultsEighty children each with asthma and controls participated in the study. Serum Zn (71.0 ± 30.3 µg/dl vs. 84.2 ± 31.7 µg/dl; p = 0.008), Se (67.3 ± 29.8 µg/l vs. 80.0 ± 31.7 µg/l; p = 0.033) and TAC [median (interquartile range) 5.2 (3.8–6.8) ng/dl vs. 6.2 (4.3–8.0) ng/dl; p = 0.019] were lower in children with asthma. Serum Se (65.7 ± 29.1 µg/l vs. 92.4 ± 28.6 µg/l; p = 0.001) was lower in those with moderate/severe than mild disease, but no association with symptoms control (p &gt; 0.05).ConclusionMicronutrient supplementation may be beneficial in Nigerian children with asthma as they have relatively lower antioxidant micronutrients than nonasthmatics
Supporting Family Caregivers: No Longer Home Alone: Eating for Healthy Aging
Authors: Steinberg Francene M. , Batchelor-Murphy Melissa K. , Young Heather M. 
Published: October 2019

This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of focus groups, conducted as part of the AARP Public Policy Institute's No Longer Home Alone video project, supported evidence that family caregivers aren't given the information they need to manage the complex care regimens of family members. This series of articles and accompanying videos aims to help nurses provide caregivers with the tools they need to manage their family member's health care at home.
The articles in this new installment of the series provide simple and useful instructions regarding nutritional principles that nurses should reinforce with family caregivers. Most articles include an informational tear sheet—Information for Family Caregivers—that contains links to the instructional videos. To use this series, nurses should read the article first, so they understand how best to help family caregivers, and then encourage caregivers to watch the videos and ask questions. For additional information, see Resources for Nurses and Resources for Family Caregivers.
Household Air Pollution from Cooking Fires Is a Global Problem
Authors: Thompson Lisa M. 
Published: October 2019

ABSTRACT
Over the past several decades, important advances have been made in the United States to ensure that our residents breathe clean air. Still, nearly 12 million homes in this country burn wood for heating. Globally, 3 billion people, or close to half of the world's population, depend on polluting solid fuels such as wood for daily cooking and heating. Unlike in the United States where stoves used for heating are vented, many homes in low-income countries use simple stoves that often lack chimneys, leading to toxic amounts of smoke inside and outside the home. Household air pollution from these fires is the 16th leading risk factor for death and disability worldwide. Childhood pneumonia, chronic obstructive pulmonary disease, and cardiovascular disease have all been associated with household air pollution globally, yet many nurses are not aware of this burden when caring for immigrants and refugees residing in the United States. Global organizations are working to provide access to clean cookstoves (those that run on electricity, solar power, or liquid fuel), and nurses can get involved. This is one step toward improving the lives of vulnerable populations in the United States and worldwide. This series is in collaboration with the Alliance of Nurses for Healthy Environments (https://envirn.org).
Direct-to-Consumer Genetic Testing and Potential Loopholes in Protecting Consumer Privacy and Nondiscrimination
Authors: Hendricks-Sturrup Rachele M. , Prince Anya E. R. , Lu Christine Y. 
Published: October 2019

(Abstracted from JAMA 2019;321(19):1869–1870)
A recent report from the National Academies of Science, Engineering, and Medicine expressed concern that more use of direct-to-consumer (DTC) genetic testing by law enforcement could impact how individuals perceive genetic testing benefits and risks. In this commentary, the authors are especially concerned that these perceived risks could add feelings of distrust or discrimination, especially for vulnerable groups and populations including immigrants, prisoners and former convicts, sexual minorities, and racial or ethnic minorities, resulting in less use of genomic medicine.
Added Value of Chromosomal Microarray Analysis Over Conventional Karyotyping in Stillbirth Work-up: Systematic Review and Meta-analysis
Authors: Martinez-Portilla R. J. , Pauta M. , Hawkins-Villarreal A. , Rial-Crestelo M. , Miño F. Paz Y , Madrigal I. , Figueras F. , Borrell A. 
Published: October 2019

(Abstracted from Ultrasound Obstet Gynecol 2019;53:590–597)
In developed countries, stillbirth occurs is approximately 3 to 6 of every 1000 pregnancies. Causes for stillbirth are varied, and chromosomal microarray analysis (CMA) has been introduced in clinical practice to help assess the genetic causes of stillbirth, in part because this technique has better resolution than what is possible using conventional karyotyping and in part because it does not require viable tissue as culturing is not required.
Systemic and breath biomarkers for asthma: an update
Authors: Mogensen Ida , James Anna , Malinovschi Andrei 
Published: October 2019

Purpose of review
Finding suitable biomarkers to phenotype asthma, identify individuals at risk of worsening and guide treatment is highly prioritized in asthma research. We aimed to provide an analysis of currently used and upcoming biomarkers, focusing on developments published in the past 2 years.

Recent findings
Type 2 inflammation is the most studied asthma mechanism with the most biomarkers in the pipeline. Blood eosinophils and fractional exhaled nitric oxide (FeNO) are those most used clinically. Recent developments include their ability to identify individuals at higher risk of exacerbations, faster decline in lung function and more likely to benefit from anti-IL-5 and anti-IL-4/-13 treatment. Certain patterns of urinary eicosanoid excretion also relate to type 2 inflammation. Results of recent trials investigating the use of serum periostin or dipeptidyl peptidase-4 to guide anti-IL-13 therapy were somewhat disappointing. Less is known about non-type 2 inflammation but blood neutrophils and YKL-40 may be higher in patients with evidence of non-type 2 asthma. Volatile organic compounds show promise in their ability to distinguish both eosinophilic and neutrophilic asthma.

Summary
The ultimate panel of biomarkers for identification of activated inflammatory pathways and treatment strategies in asthma patients still lies in the future, particularly for non-type 2 asthma, but potential candidates are available.
Continuing Professional Development Engagement—A UK-based Concept Analysis
Authors: Hearle Deb , Lawson Sarah 
Published: October 2019

Introduction:
Although much literature exists regarding the operationalization of the term engagement, this relates specifically to work/employee engagement and user, consumer, and scholarly engagement. There is no clear understanding of the term Continuing Professional Development (CPD) engagement for allied health professionals and Nurses and Midwives in the UK, although it is becoming a frequently used term. This raises the challenge of creating measures of the impact of CPD engagement. This concept analysis therefore sought to operationalize the term CPD engagement.

Methods:
A theoretical concept analysis was undertaken, as part of a Professional Doctorate, using Walker and Avant's Concept Analysis Framework. Literature was accessed via OVID, PubMed, CINAHL, ERIC, ABI INFO, and PsychINFO using search terms engagement, work/employee, user, consumer, scholarly engagement, CPD, and life-long learning.

Results:
Defining attributes for CPD engagement included criteria based around the terms such as self-initiated, voluntary, applied, recorded, evaluated and shared, and continuation of learning beyond the initial activity. Antecedents focused around drive and availability of resources including time, money, and support.

Discussion:
There are potentially many positive consequences of CPD engagement, such as job satisfaction, employee retention, and quality of service provision, that may be more easily investigated and measured against the attributes defined from this study, which indicates that CPD engagement is characterized by the following five criteria: (1) self-initiated; (2) rewarded (either intrinsically or extrinsically); (3) applied in practice; (4) recorded, evaluated, and shared with others; and finally (5) continues beyond the initial learning activity.
Eyebrow Hair Transplantation in Frontal Fibrosing Alopecia: Pitfalls of Short- and Long-Term Results
Authors: Audickaite Aiste , Alam Majid , Jimenez Francisco 
Published: October 2019

BACKGROUND
Eyebrow hair loss is usually a primary feature of frontal fibrosing alopecia (FFA), which causes significant distress to patients and consequently seek medical help. Eyebrow hair transplantation is a well-accepted and aesthetically successful treatment, but there is a lack of information about the short- and long-term results in this subset of patients.

OBJECTIVE
To report the short- and long-term eyebrow hair transplantation results in patients with FFA.

PATIENTS AND METHODS
Ten patients diagnosed with FFA underwent eyebrow hair transplantation. The transplanted hairs were harvested from nonaffected follicles of the occipital scalp skin. On average, 120 to 270 single-hair follicles were implanted per eyebrow.

RESULTS
Eighty percent of patients achieved excellent hair growth at 6- to 12-month follow-up and satisfactory short-term results (<2 years). However, majority started losing the transplanted hairs after 3 to 4 years. Only 1 patient did not lose transplanted hair in the long-term follow-up (>4 years).

CONCLUSION
The results of eyebrow hair transplantation in FFA patients are variable and contentious. The short-term outcome is satisfactory, but in most patients, a progressive loss of transplanted hairs can be expected. Therefore, FFA patients inquiring about eyebrow transplantation should be advised about the high possibility of hair graft loss over time.
Clozapine and Norclozapine Plasma Levels in Patients Switched Between Different Liquid Formulations
Authors: Oloyede Ebenezer , Dzahini Olubanke , Whiskey Eromona , Taylor David 
Published: October 2019

Background and Objective:
Clozapine is the drug of choice for treatment-resistant schizophrenia. The primary objective of this study was to compare plasma clozapine and N-desmethylclozapine levels in patients switched between 2 liquid formulations [Denzapine suspension and clozapine oral solution (St George's ZTAS)]. Secondary objectives included comparison of safety, tolerability, and patient acceptability.

Methods:
This was a noninterventional, observational, prospective follow-up of patients consecutively switched between formulations of clozapine liquid in a large inner-city NHS mental health trust. The authors also performed retrospective analysis of outcomes from patient case notes.

Results:
The authors identified 43 patients receiving Denzapine suspension in the trust. Data were available for 43 patients switched from Denzapine to clozapine oral solution (St George's ZTAS), among whom, 15 (32%) were excluded from the analysis. Of the 28 patients for whom data were available, the 90% confidence interval for the ratio of mean values for corrected Cmin 91.5 (85.2%–98.4%) and uncorrected Cmin 91.2 (84.4%–98.6%) were within the guideline range of bioequivalence (80%–125%). Safety and tolerability profiles were comparable between the 2 formulations (P = 0.10). Patient acceptability was also similar between the brands in most domains. However, there was a taste preference for Denzapine suspension.

Conclusions:
No significant difference in clozapine plasma levels was observed after switching from Denzapine suspension to a recently introduced clozapine solution. This study also highlights the significance of medicinal characteristics such as taste for patient acceptability and compliance.
Low Bone Mineral Density and High Bone Turnover in Patients With Non-Hodgkin's Lymphoma (NHL) Who Receive Frontline Therapy: Results of a Multicenter Prospective Study
Authors: Anargyrou Konstantinos , Fotiou Despina , Vassilakopoulos Theodoros P. , Christoulas Dimitrios , Makras Polyzois , Dimou Maria , Ntanasis-Stathopoulos Ioannis , Masouridou Stavroula , Angelopoulou Maria K. , Papatheodorou Athanasios , Tsionos Konstantinos , Panayiotidis Panayiotis , Dimopoulos Meletios A. , Terpos Evangelos 
Published: October 2019

Abstract
Chemotherapy associated osteoporosis is a severe problem in patients with malignant diseases as it increases the risk for fractures and deteriorates quality of life. There are very limited data in the literature for the effect of chemotherapy on bone metabolism of adult patients with Non-Hodgkin Lymphoma (NHL). We prospectively evaluated bone remodeling pre- and post-chemotherapy in 61 patients with newly diagnosed NHL. First-line chemotherapy resulted in high bone turnover, which led to increased bone loss and reduced bone mineral density (BMD) of lumbar spine (L1-L4) and femur neck (FN). The reduction of L1-L4 and FN BMD post-chemo was more profound in males and in older patients (>55 years). Patients who received 8 cycles of chemotherapy had a greater reduction of L1-L4 and FN BMD as compared to 6 cycles. The administration of chemotherapy also resulted in a dramatic increase of bone resorption markers (CTX and TRACP-5b), bone formation markers, (bALP and Osteocalcin) and of osteoblast regulator Dickkopf-1. During study period, one patient had a pathological fracture in his right FN.