bluuebunny/crossref_metadata_2025_split huggingface dataset:
TFEB Links MYC Signaling to Epigenetic Control of Myeloid Differentiation and Acute Myeloid Leukemia
Authors: Yun Seongseok , Vincelette Nicole D. , Yu Xiaoqing , Watson Gregory W. , Fernandez Mario R. , Yang Chunying , Hitosugi Taro , Cheng Chia-Ho , Freischel Audrey R. , Zhang Ling , Li Weimin , Hou Hsinan , Schaub Franz X. , Vedder Alexis R. , Cen Ling , McGraw Kathy L. , Moon Jungwon , Murphy Daniel J. , Ballabio Andrea , Kaufmann Scott H. , Berglund Anders E. , Cleveland John L. 
Published: December 2020

Abstract

MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism, and tumorigenesis. A variety of alterations drive MYC expression in acute myeloid leukemia (AML), and enforced MYC expression in hematopoietic progenitors is sufficient to induce AML. Here we report that AML and myeloid progenitor cell growth and survival rely on MYC-directed suppression of Transcription Factor EB (TFEB), a master regulator of the autophagy–lysosome pathway. Notably, although originally identified as an oncogene, TFEB functions as a tumor suppressor in AML, where it provokes AML cell differentiation and death. These responses reflect TFEB control of myeloid epigenetic programs by inducing expression of isocitrate dehydrogenase-1 (IDH1) and IDH2, resulting in global hydroxylation of 5-methycytosine. Finally, activating the TFEB–IDH1/IDH2–TET2 axis is revealed as a targetable vulnerability in AML. Thus, epigenetic control by an MYC–TFEB circuit dictates myeloid cell fate and is essential for maintenance of AML.

Significance:
Alterations in epigenetic control are a hallmark of AML. This study establishes that a MYC–TFEB circuit controls AML differentiation and epigenetic programs by inducing IDH1/IDH2 and hydroxylation of 5-methylcytosine, that TFEB functions as a tumor suppressor in AML, and that this circuit is a targetable vulnerability in AML.
See related commentary by Wu and Eisenman, p. 116.
Selective Solidarity and Discursive Modulation in the Brazilian Public Sphere
Authors: Blotta Vitor 
Published: December 2020

Abstract
In this article the author argues that solidarity can be used as an analytical concept in order to understand the dynamics of discourses in the public spheres of contemporary democracies. He begins by discussing conceptions of solidarity in political theory, followed by descriptions of its manifestations in recent public debates in different countries. After that, he relates solidarity to Habermas’s formal-pragmatic concept of communicative rationality, which enables him to sketch out notions such as discursive and selective solidarity, as well as discursive modulations of solidarity, which are formulated through analogies of discourse theory and musical theory. In the last part of the article, the author applies these notions to three specific examples of public debates in the Brazilian public sphere.
The Faust Variations
Authors: Toscano Alberto 
Published: December 2020

Abstract
This essay explores Jameson’s reading of Goethe’s Faust II in Allegory and Ideology, putting it into dialogue with enquiries into Goethian allegory by other Marxist critics, namely Georg Lukács, Cesare Cases and Franco Fortini. Allegories of monetisation and dispossession in Faust II are explored, along with the limits of Lukács’s partial devaluation of the allegorical. The essay focuses in particular on how Jameson’s reading of Faust II can be interpreted as an allegory of theory itself, and in particular of the dialectic, thereby returning us to Lukács’s own parallel reading of Faust and Hegel’s Phenomenology, albeit in a different key.
Perfect War: Alberico Gentili on the Use of Force and the Early Modern Law of Nations
Authors: Vadi Valentina 
Published: December 2020

Abstract
Gentili’s conceptualization of war as a conflict between states attempted to limit the legitimacy of war to external wars only, thus precluding the legitimacy of civil wars. It reflected both the emergence of sovereign states and the vision of international law as a law among polities rather than individuals. The conceptualization of war as a dispute settlement mechanism among polities rather than a punishment for breach of the law of nations and the idea of the bilateral justice of war humanized the conduct of warfare and the content of peace treaties. The idea of perfect war excluded brigandage, piracy, and civil wars from its purview. Some scholars have suggested that perfect war had a dark side, legitimizing imperial expansion. Others have cautioned that Gentili explicitly opposed imperial expansion rather adopting anti-imperialist stances. This article suggests that these ambivalent readings of the Gentilian oeuvre reflect the ambivalence of the early modern law of nations. Under the early modern law of nations, aggression for the sake of empire was clearly unjust; nonetheless, imperial expansion took place. Whereas ‘a law which many transgress[ed] [wa]s nonetheless a law’, there was a wide divide between theory and practice.1
“Look’d Like Milk”: Colonialism and Infant Feeding in the English Atlantic World
Authors: Cevasco Carla 
Published: December 2020

Abstract
While wet nursing interactions between enslaved women of African descent and colonial women have received extensive scholarly attention, much remains to be done in understanding colonial and Native women’s interactions around breastfeeding and infant feeding. This article close-reads two captivity narratives in which baby food features prominently: God’s Protecting Providence, Jonathan Dickinson’s 1699 narrative of being shipwrecked among Ais, Jeaga, Jobé, Santaluces, and Surruque Indians in coastal Florida in 1696; and God’s Mercy Surmounting Man’s Cruelty, Elizabeth Hanson’s 1728 narrative of being captured by Wabanaki people during Dummer’s War in 1724. Captivity rendered the colonists dependent upon intimate Native care for the survival of their children. When Dickinson and Hanson crafted their narratives of their captivities, however, they sought to reinscribe colonial supremacy after experiences that called it into question. The complexities of colonial-Native interactions around infant feeding in these sources demonstrate the need for further scholarship on reproduction and settler colonialism.
Secondary Malignancies: The Cost of Progress
Authors: Silberman Allan W. , Quadri Humair S. , Amersi Farin 
Published: December 2020

Background With advances in treatment of cancer, patients who survive their first malignancy are at risk of developing additional malignancies. Data on the risks of secondary malignancies after treatment of some of the more common cancers are lacking. Methods Our prospectively maintained database was queried from 1996 to 2016 to identify patients with breast cancer, colorectal cancer, melanoma, sarcoma, gastric, and pancreatic adenocarcinoma who developed additional malignancies. Predisposing clinical factors were included in our analysis. Results We identified 756 patients diagnosed with a solid malignancy who developed a second malignancy, of which 606 (80.1%) had one of the most common treated cancers. 59.5% of patients were women. 810 additional malignancies were identified in the 606 patients with breast and colon cancer being the most common secondary malignancies. Of these 606 patients, 460 (76%) patients had two malignancies; 145 (23.9%) had 3 or more malignancies. 15.2% of patients were diagnosed under the age of 40.63 years. 8.3% patients had a known genetic mutation, with BReast CAncer gene, and Lynch mutations being the most common. Conclusion Advances in cancer treatment have led to higher cure rates. These patients should continue surveillance and undergo screening as they may be at risk of developing additional malignancies.
Time in the Mental Health Context: Neurotic Symptomatology, Defense Mechanisms and the Perception of Time Perspective Among Patients Diagnosed With Neurotic and Personality Disorders – A Clinical Study
Authors: Mostowik Joanna , Mielimąka Michał , Rutkowski Krzysztof , Ostrowski Tadeusz 
Published: December 2020

Aim The main objective of the study is to explore relations between the time perspective, neurotic symptoms, anxiety, and defense mechanisms in the group of patients diagnosed with neurotic and personality disorders (ICD-10 groups: F4x, F60.x and F61) treated with group psychotherapy. The research is conducted on the theoretical basis of the Zimbardo and Boyd’s Time Perspective Theory. Methods The study included 49 patients treated in the day ward for the Treatment of Neurotic Disorders and Behavioral Syndromes at the University Hospital. The measurement of the TP was performed with the Zimbardo Time Perspective Inventory. Patients also completed the State-Trait Anxiety Inventory and the Defense Style Questionnaire 40. The diagnosis was done by licensed psychiatrists and supported with the measures: Symptom Checklist KO“O”, Neurotic Personality Questionnaire KON-2006. Results Multiple regression analysis models showed that the four time perspectives (past negative, present fatalistic, present hedonistic, and future) are predicted in different variations by the level of anxiety state or trait and repertoire of used defense mechanisms (immature or mature). Conclusions Considering the established bilateral correlations, change in the time perspective may constitute an important factor in the reduction of neurotic symptoms, possibly through changes in the repertoire of utilized defense mechanisms. However, there is also possible that altering neurotic symptomatology would alter time perspective. The assessment of the time perspective in patients with neurotic and personality disorders may provide useful data for the diagnosis and the monitoring of psychotherapy effectiveness. Based on the results of this study conducting further research on the role of the changes in the time perspective in the course of psychotherapy is recommended and necessary to expand the understanding of the relations observed in this study.
Status of cardiovascular surgery in Japan between 2017 and 2018: A report based on the Japan Cardiovascular Surgery Database. 4. Thoracic aortic surgery
Authors: Shimizu Hideyuki , Hirahara Norimichi , Motomura Noboru , Miyata Hiroaki , Takamoto Shinichi 
Published: December 2020

Aim We aimed to analyze the current treatment status of thoracic/thoracoabdominal aortic diseases in Japan. Methods Using the Japan Cardiovascular Surgery Database, the number of cases, operative mortality, and major morbidities (stroke, renal failure, pneumonia, paraplegia) of thoracic and thoracoabdominal aortic surgery in 2017 and 2018 were analyzed by surgical site (root-ascending, arch, descending, thoracoabdominal aorta), surgical procedure, and age group. Results The total number of cases was 39,391 (50.1% aortic dissections, 49.9% non-dissections). The number of cases was highest in patients aged in their 70s. In elderly patients, the rates of root replacement (particularly valve-sparing procedures) in the root-ascending aorta and open-chest surgery in the arch and the descending and thoracoabdominal aorta were decreased. The outcome by procedure analysis showed the lowest mortality and morbidity rates for valve-sparing in the root-ascending region, and lower mortality and morbidity (cerebral infarction, renal failure, pneumonia) in non-open-chest procedures (thoracic endovascular aortic repair with/without branch reconstruction) than in open-chest procedures in the arch, descending, and thoracoabdominal regions. With regards to age, operative mortality in patients aged 80 years or older was significantly higher than in those under 80 years of age for all surgical procedures in the root-ascending, arch, and descending regions. Conclusions Thoracic and thoracoabdominal aortic surgery in Japan was most commonly performed in elderly patients in their 70s, with a good overall mortality rate of 5.3%. Mortality and postoperative morbidity rates in patients aged 80 years or older were still high. In the future, further improvements in surgical outcomes are needed.
Pharmacotherapy of attention deficit/hyperactivity disorder in individuals with autism spectrum disorder: A systematic review of the literature
Authors: Joshi Gagan , Wilens Timothy , Firmin Elizabeth S , Hoskova Barbora , Biederman Joseph 
Published: December 2020

Aim: To assess the empirical evidence for the treatment of attention deficit/hyperactivity disorder (ADHD) in populations with autism spectrum disorder (ASD). Methods: A systemic PubMed, PsychINFO, Embase, and Medline database search of peer-reviewed literature was conducted. Included in the review were controlled trials published in English with sample sizes ⩾10 participants examining the safety and efficacy of anti-ADHD medication in ASD populations. Data was extracted on relevant variables of study design, demographics, associated psychopathology, medication dose, efficacy, and tolerability. Results: Nine controlled trials met the inclusion and exclusion criteria: five with methylphenidate, three with atomoxetine, and one with guanfacine. Sample sizes ranged from 10 to 128 with 430 children participating across all the trials. In all the trials, treatment response was significantly superior to placebo. However, almost all trials assessed only hyperactivity, and most included only participants with intellectual disability with high levels of irritability. None of the trials distinguished agitation from hyperactivity. The response on hyperactivity for methylphenidate and atomoxetine was less than that observed in the neurotypical population; however, the response for guanfacine surpassed results observed in neurotypical populations. Treatment-emergent mood lability (i.e. mood dysregulation and mood-related adverse events) was frequently associated with methylphenidate and guanfacine treatments. Worse treatment outcomes were associated with individuals with lower intellectual capability compared with those with higher IQs. Conclusions: here is a scarcity of controlled trials examining ADHD treatments in ASD populations, particularly in intellectually capable individuals with ASD and in adults. Response to ADHD medications in ASD were adversely moderated by the presence of intellectual disability and mood lability.
Quality Assurance in Lactation: Reliability of OM-6050 Station System to Test Mother’s Milk Osmolality
Authors: Macias-Muñoz Laura , Herranz Barbero Ana , Wijngaard Robin , Salvia-Roigés Mª. Dolors , Rico Naira 
Published: December 2020

Background Mother’s own milk does not provide enough nutrients to feed a preterm baby born before 32 weeks’ gestation; therefore, human milk fortifiers are needed. However, human milk fortifiers increase the osmolality, and enteral administration of high osmolality fluids has been associated with gastrointestinal symptoms. For this reason, it is necessary for laboratories to have a validated system in order to measure human milk osmolality. Research aim The aim of this study was to validate the OM-6050 Station System for measuring the osmolality of fortified mother’s milk samples. Methods Osmolality was measured using the osmometer OM-6050 Station System. Milk samples from healthy mothers ( N = 3) unfortified and with two fortifiers (Almirón Fortifier® or NAN FM85®), as well as a nutritional supplement (Duocal MCT®) were used in the validation study through precision and linearity analysis. Results In the precision study the mean intra-assay coefficient of variation was 1.2% and 1.7% for mother’s milk and fortified mother’s milk, respectively. The mean inter-assay coefficient of variation was ≤ 1% in both cases. In the linearity study the regression analysis had a linear response to fortified mother’s milk osmolality between 294 mOsm/kg and 539 mOsm/kg. Conclusion The osmometer OM-6050 Station was reliable for determining the osmolality of fortified and unfortified mother’s milk. It may be useful in the clinical practices within Neonatal Intensive Care Units.
Facilitated Stories for Change: Digital Storytelling as a Tool for Engagement in Facilitated Discussion for Reduction of Diabetes-Related Health Disparities Among Rural Latino Patients With Diabetes
Authors: Carlson Lauren Mary , Ridgeway Jennifer L. , Asiedu Gladys B. , Wieland Mark L. , Sia Irene G. , Porraz Capetillo Graciela , Bernard Matthew E. , Hanza Marcelo M. , Njeru Jane W. 
Published: December 2020

Introduction Latino populations, particularly those living in rural areas, experience a disproportionately high prevalence and poorer outcomes of type 2 diabetes mellitus (T2DM). The purpose of this study was to test the acceptability and perceived effectiveness of a group-based, facilitated digital storytelling intervention for T2DM self-management among rural Latino patients. Method Twenty Latino adults with T2DM participated in facilitated storytelling discussions at two primary clinics. Participants viewed a 12-minute T2DM self-management digital storytelling intervention, followed by a facilitated group discussion. Surveys, observations, and focus groups were used to assess for acceptability and perceived effectiveness of the intervention through descriptive and qualitative analysis, informed by narrative and social cognitive theory. Results All participants found the intervention interesting and useful and reported improvement in confidence, motivation, and behavioral intentions for T2DM self-management. Themes mapped closely with narrative theory models, further suggestive of the behavior change potential. Discussion Facilitated discussions may add value to viewing of digital stories and represent a scalable approach to provide culturally congruent health care for Latino patients with diabetes in rural settings. Within the paradigm of group-based diabetes educational programs, this lends itself well to critical transcultural nursing care.
Oral Superabsorbent Hydrogel (Plenity) for Weight Management
Authors: Pass Alexa , Bialonczyk Damian , Chiquette Elaine , Goldman Jennifer D. 
Published: December 2020

Objective To describe the mechanism, clinical trial data, adverse effects, and potential role in therapy of an oral superabsorbent hydrogel (OSH) for weight management. Data Sources A literature search was completed using MEDLINE and Google Scholar using the following search terms: oral superabsorbent hydrogel, Plenity, and Gelesis100 (September 1999 to July 2020). Abstracts and posters were identified from relevant scientific congress archives and published supplements. Study Selection and Data Extraction All available studies were considered. Only human studies were used for drug interaction, efficacy, and safety data. Data Synthesis OSH is a first-in-class, nonsystemic agent for weight management. It is indicated for use in patients with a body mass index (BMI) of 25 to 40 kg/m2 regardless of comorbidity status. OSH functions primarily through space occupancy in the stomach and small intestine. Studies have demonstrated that OSH has modest weight loss efficacy and a favorable safety profile, with no significant difference in overall adverse events compared with placebo. Relevance to Patient Care and Clinical Practice OSH is one of the only prescription antiobesity therapeutics (AOTs) that can be utilized in overweight patients with BMI equal to 25 to 30 kg/m2, regardless of comorbidity status. Given its nonsystemic mechanism of action and safety profile, OSH may help shift the focus of weight management toward patients with a lower BMI. Conclusions OSH offers a nonsystemic approach to weight management for patients who are diagnosed with overweight or obesity. As an alternative option to current pharmacological AOTs, OSH may address an existing clinical gap in weight management.
Vision-related quality of life in patients with a history of congenital glaucoma
Authors: Miraftabi Arezoo , Coleman Anne L , Nilforushan Naveed , Parsamanesh Mohammad , Nguyen Andrew H , Karimi Nasser , Chibaksh Samira 
Published: December 2020

Purpose: To assess the vision-related quality of life in adult patients with a history of primary congenital glaucoma. Methods: In a cross-sectional hospital-based study eligible patients with a history of primary congenital glaucoma aged more than 18 were recruited in the study. Patients with secondary glaucoma and monocular patients were excluded. All patients underwent a complete ophthalmologic examination. The subjects were requested to answer a Persian approved version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) questionnaire. Results: A total of 23 congenital glaucoma patients have enrolled in the study. The mean age was 29.22 (9.3 SD) and mean IOP was 13.82 (5.19 SD) and 15.69 (5.26 SD) in right and left eyes, respectively. The mean number of medications was 1.13 (1.25 SD) in the right and 1.30 (1.18 SD) in the left eyes. Among all scores of NEI-VFQ-25, the lowest score belonged to mental health 53.71 (29.72) and the highest score was color vision score 83.69 (20.79). We found a significant influence of visual field defect on many subscales including general health and general vision ( p = 0.007, R = +0.65) and ( p = 0.002, R = +0.71) respectively. The Mean Defect (MD) was associated with low social functioning and peripheral vision too ( p = 0.035, R = +0.53) and ( p = 0.001, R = +0.76) respectively. Age had a negative impact on the general vision subscale ( p = 0.003, R = −0.59). Conclusion: Our study showed that visual field defect was strongly associated with many subscales scores in (NEI VFQ-25) questionnaire.
Applicability of left distal radial artery access site in ST-segment elevation myocardial infarction; A comparative evaluation with the conventional transfemoral approach
Authors: Soydan Elton , Akın Mustafa 
Published: December 2020

Background: Left distal radial artery (LDRA) has got high popularity as an alternative safe access site in coronary angiography. However, little is known about its applicability in primary percutaneous coronary intervention (PPCI) in ST-segment elevation myocardial infarction (STEMI) patients. We aimed to assess the convenience of LDRA access in STEMI patients and make the comparative evaluation with the transfemoral (TF) route. Materials and methods: A total of 91 consecutive STEMI patients who underwent PPCI from January to June 2019, were analyzed. Experienced operators, unaware of the study were left free of access site decision. Comparative demographic features and clinical outcomes were recorded during hospitalization. Results: LDRA was used in 30 patients, whereas 61 patients underwent a TF approach. Successful PPCI was achieved in high rates in both groups (LDR: 90% vs TF: 91.8%: p = 0.795). On admission, KILLIP (II, III) class was higher in the LDRA group (23.3% vs 3.4%), whereas stent thrombosis, arhythmias were higher in the TF group (0% vs 6.6% p = 0.151; 6.7% vs 18% p = 0.355 respectively). Puncture time was relatively similar between groups (28.63 vs 28.93 s p = 0.767). Fluoroscopy time, total radiation exposure and hospital duration was found lower in the LDRA group (10.11 vs 13.75 min p < 0.001; 917.87 vs 1940.91 mGy p < 0.001; 4.2 vs 6.2 days p = 0.024 respectively). In-hospital mortality was found higher in the TF group (0% vs 18% p = 0.013). Conclusion: In the acute management of STEMI, LDRA access site can be a convenient alternative to TF approach with shorter hospital duration and complication rates.