bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severity of Pectus Excavatum is a Risk Factor for Primary Spontaneous Pneumothorax
Authors: Huang Hsu‐Kai , Huang Yi‐Jhih , Lin Kuan‐Hsun , Chen Ying‐Yi , Ko Kai‐Hsiung , Chang Hung , Lee Shih‐Chun , Huang Tsai‐Wang 
Published: February 2020

AbstractBackground and ObjectiveThis study aimed to investigate the relationship between bleb formation, primary spontaneous pneumothorax (PSP) and pectus excavatum (PE).MethodsFrom July 2005 to December 2016, the records of 514 patients with PE who underwent the Nuss procedure were obtained from a prospectively collected database and reviewed. Clinical features, images and treatments were analyzed retrospectively.ResultsThe incidence rate of bleb formation was 26.5% in PE patients. The bleb group had a greater body height (174.4 cm vs. 170.4 cm, p < 0.001), a higher Haller index (HI; 4.2 vs. 3.43, p < 0.001) and a higher risk of developing PSP than the non‐bleb group (risk ratio 9.8, p = 0.002). HI values larger than 3.615 had good discriminatory power for predicting bleb formation in patients with PE. With each increase in the HI, PE patients had a 2.2‐fold greater odds ratio of bleb formation (odds ratio 2.221, CI 1.481–3.330, p < 0.001).ConclusionWe discovered that a high percentage of PE patients have bleb formation and a higher risk of PSP, especially those with an HI >3.615. High‐resolution computed tomography of the chest may be useful for evaluating both the HI and the presence of blebs in the lungs before performing a corrective surgical procedure.
Individual therapeutic DAS28-dcrit responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes: retrospective analysis of DAS28 responses in comparative tocilizumab studies
Authors: Koehm Michaela , McIntosh Matthew J. , Hofmann Michael W. , Abraham Varghese , Gabay Cem , Choy Ernest H. , Kavanaugh Arthur , Burkhardt Harald , Behrens Frank 
Published: February 2020

AbstractAssessment of individual therapeutic responses provides valuable information concerning treatment benefits in individual patients. We evaluated individual therapeutic responses as determined by the Disease Activity Score-28 joints critical difference for improvement (DAS28-dcrit) in rheumatoid arthritis (RA) patients treated with intravenous tocilizumab or comparator anti-tumor necrosis factor (TNF) agents. The previously published DAS28-dcrit value [DAS28 decrease (improvement) ≥ 1.8] was retrospectively applied to data from two studies of tocilizumab in RA, the 52-week ACT-iON observational study and the 24-week ADACTA randomized study. Data were compared within (not between) studies. DAS28 was calculated with erythrocyte sedimentation rate as the inflammatory marker. Stability of DAS28-dcrit responses and European League Against Rheumatism (EULAR) good responses was determined by evaluating repeated responses at subsequent timepoints. A logistic regression model was used to calculate p values for differences in response rates between active agents. Patient-reported outcomes (PROs; pain, global health, function, and fatigue) in DAS28-dcrit responder versus non-responder groups were compared with an ANCOVA model. DAS28-dcrit individual response rates were 78.2% in tocilizumab-treated patients and 58.2% in anti-TNF-treated patients at week 52 in the ACT-ion study (p = 0.0001) and 90.1% versus 59.1% at week 24 in the ADACTA study (p < 0.0001). DAS28-dcrit responses showed greater stability over time (up to 52 weeks) than EULAR good responses. For both active treatments, DAS28-dcrit responses were associated with statistically significant improvements in mean PRO values compared with non-responders. The DAS28-dcrit response criterion provides robust assessments of individual responses to RA therapy and may be useful for discriminating between active agents in clinical studies and guiding treat-to-target decisions in daily practice.
Physical evaluation of an ultra-high-resolution CT scanner
Authors: Oostveen Luuk J. , Boedeker Kirsten L. , Brink Monique , Prokop Mathias , de Lange Frank , Sechopoulos Ioannis 
Published: February 2020

Abstract
Objectives
To evaluate the technical performance of an ultra-high-resolution CT (UHRCT) system.

Methods
The physico-technical capabilities of a novel commercial UHRCT system were assessed and compared with those of a current-generation multi-detector (MDCT) system. The super-high-resolution (SHR) mode of the system uses 0.25 mm (at isocentre) detector elements (dels) in the in-plane and longitudinal directions, while the high-resolution (HR) mode bins two dels in the longitudinal direction. The normal-resolution (NR) mode bins dels 2 × 2, resulting in a del-size equivalent to that of the MDCT system. In general, standard procedures and phantoms were used to perform these assessments.

Results
The UHRCT MTF (10% MTF 4.1 lp/mm) is twice as high as that of the MDCT (10% MTF 1.9 lp/mm), which is comparable to the MTF in the NR mode (10% MTF 1.7 lp/mm). The width of the slice sensitivity profile in the SHR mode (FWHM 0.45 mm) is about 60% of that of the MDCT (FWHM 0.77 mm). Uniformity and CT numbers are within the expected range. Noise in the high-resolution modes has a higher magnitude and higher frequency components compared with MDCT. Low-contrast visibility is lower for the NR, HR and SHR modes compared with MDCT, but about a 14%, for NR, and 23%, for HR and SHR, dose increase gives the same results.

Conclusions
HR and SHR mode scanning results in double the spatial resolution, with about a 23% increase in dose required to achieve the same low-contrast detectability.

Key Points
• Resolution on UHRCT is up to twice as high as for the tested MDCT.
• With abdominal settings, UHRCT needs higher dose for the same low-contrast detectability as MDCT, but dose is still below achievable levels as defined by current diagnostic reference levels.
• The UHRCT system used in normal-resolution mode yields comparable resolution and noise characteristics as the MDCT system.
New approaches to the study of immune responses in humans
Authors: Brodin Petter 
Published: February 2020

AbstractThe human immune system consists of multiple, layered mechanisms of sensing and responding to cellular stress, infection and tissue damage to ensure defense from pathogens, maintenance of tissue homeostasis, and the integrity of the holobiont. Every single cell in the body has a role to play, but a few dozen, specialized white blood cells are particularly important in this respect. Understanding the overall state of this multifaceted system in a single individual is challenging, and we are only beginning to do this across populations of individuals, to understand the vast range of inter-individual variation, and the influences of genes and environmental factors that collectively shape the immune system in a given individual. We are also only beginning to understand the changes occurring within this system over time, and how this relates to health and disease susceptibility. Several technological breakthroughs in recent years have enabled these developments and the emergence of a new, complementary approach to studying human immune systems, namely systems immunology. In this paradigm, the focus is shifted from the understanding of individual immune system components and their mechanisms of action, towards analyses of cell–cell interactions, and mechanisms of coordination and regulation within the human immune system.
Characterizing Peatland Microtopography Using Gradient and Microform-Based Approaches
Authors: Graham Jake D. , Glenn Nancy F. , Spaete Lucas P. , Hanson Paul J. 
Published: February 2020

AbstractPeatlands represent an important component of the global carbon cycle, storing 180–621 Gt of carbon (C). Small-scale spatial variations in elevation, frequently referred to as microtopography, influence ecological processes associated with the peatland C cycle, includingSphagnumphotosynthesis and methane flux. Microtopography can be characterized with measures of topographic variability and by using conceptual classes (microforms) linked to function: most commonly hummocks and hollows. However, the criteria used to define these conceptual classes are often poorly described, if at all, and vary between studies. Such inconsistencies compel development of explicit quantitative methods to classify microforms. Furthermore, gradient-based characterizations that describe spatial variability without the use of microforms are lacking in the literature. Therefore, the objectives of this study were to (1) calculate peatland microtopographical elevation gradients and measures of spatial variability, (2) develop three microform classification methods intended for specific purposes, and (3) evaluate and contrast classification methods. Our results suggest that at spatial scales much larger than microforms, elevation distributions are unimodal and are well approximated with parametric probability density functions. Results from classifications were variable between methods and years and exhibited significant differences in mean hollow areal coverages of a raised ombrotrophic bog. Our results suggest that the conceptualization and classification of microforms can significantly influence microtopographic structural metrics. The three explicit methods for microform classification described here may be used and built upon for future applications.
Novel clustering-based pruning algorithms
Authors: Zyblewski Paweł , Woźniak Michał 
Published: February 2020

AbstractOne of the crucial problems of designing a classifier ensemble is the proper choice of the base classifier line-up. Basically, such an ensemble is formed on the basis of individual classifiers, which are trained in such a way to ensure their high diversity or they are chosen on the basis of pruning which reduces the number of predictive models in order to improve efficiency and predictive performance of the ensemble. This work is focusing on clustering-based ensemble pruning, which looks for the group of similar classifiers which are replaced by their representatives. We propose a novel pruning criterion based on well-known diversity measures and describe three algorithms using classifier clustering. The first method selects the model with the best predictive performance from each cluster to form the final ensemble, the second one employs the multistage organization, where instead of removing the classifiers from the ensemble each classifier cluster makes the decision independently, while the third proposition combines multistage organization and sampling with replacement. The proposed approaches were evaluated using 30 datasets with different characteristics. Experimentation results validated through statistical tests confirmed the usefulness of the proposed approaches.
Access to Meckel’s cave for biopsies of indeterminate lesions: a systematic review
Authors: Suero Molina E , Revuelta Barbero JM , Ewelt C , Stummer W , Carrau RL , Prevedello DM 
Published: February 2020

AbstractAccessing Meckel’s cave (MC) is surgically challenging. Open approaches are complex and often correlated with high morbidity. Endoscopic approaches emerged in the last decade as feasible alternatives to open approaches, especially for sampling indeterminate lesions. This article first analyses available routes to approach Meckel’s cave and presents furthermore an illustrative case. We conducted a systematic review and reported according to the guidelines for preferred reporting items for systematic reviews and meta-analyses (PRISMA). Various surgical approaches identified through the search are evaluated and discussed in detail. Additionally, we report on a case of woman with a lesion in MC, which was accessed through an endoscopic transpterygoid approach subsequently diagnosed as a diffuse large B cell lymphoma. Our search delivered 75 articles that included case reports (n = 21), cadaveric studies (n = 32), clinical articles (n = 16), review of the literatures (n = 3), as well as technical notes (n = 2) and a radiological manuscript (n = 1). Open routes included lateral approaches with many variations, mainly intra- and extradural pterional approaches and anterior petrosal, as well as a retrosigmoid intradural suprameatal and a lateral transorbital approach. Endoscopically, MC was reached via approaches that included transpterygoid, transorbital or infraorbital fissure routes. Percutaneous approaches, e.g. through the foramen ovale, were also described. Multiple surgical approaches to MC are currently available. Their different characteristics as well as individual patient factors, such as clinical history and the localization of the disease, have to be considered when choosing a surgical corridor. Studies included in this review highlight the endonasal endoscopic transpterygoidal technique as an excellent corridor for biopsies in the ventral MC.
Nonlinear viscoelastic constitutive model for bovine liver tissue
Authors: Capilnasiu Adela , Bilston Lynne , Sinkus Ralph , Nordsletten David 
Published: February 2020

AbstractSoft tissue mechanical characterisation is important in many areas of medical research. Examples span from surgery training, device design and testing, sudden injury and disease diagnosis. The liver is of particular interest, as it is the most commonly injured organ in frontal and side motor vehicle crashes, and also assessed for inflammation and fibrosis in chronic liver diseases. Hence, an extensive rheological characterisation of liver tissue would contribute to advancements in these areas, which are dependent upon underlying biomechanical models. The aim of this paper is to define a liver constitutive equation that is able to characterise the nonlinear viscoelastic behaviour of liver tissue under a range of deformations and frequencies. The tissue response to large amplitude oscillatory shear (1–50%) under varying preloads (1–20%) and frequencies (0.5–2 Hz) is modelled using viscoelastic-adapted forms of the Mooney–Rivlin, Ogden and exponential models. These models are fit to the data using classical or modified objective norms. The results show that all three models are suitable for capturing the initial nonlinear regime, with the latter two being capable of capturing, simultaneously, the whole deformation range tested. The work presented here provides a comprehensive analysis across several material models and norms, leading to an identifiable constitutive equation that describes the nonlinear viscoelastic behaviour of the liver.
Entwicklungspfade der Straftäterbehandlung: skizzierte Wege und Evaluation der Zielerreichung
Authors: Lösel Friedrich 
Published: February 2020

ZusammenfassungDer Aufsatz gibt einen Überblick über die Konzepte und empirischen Evaluationsergebnisse zur Straftäterbehandlung seit den 1960er-Jahren. Zahlreiche Metaanalysen zeigen im Durchschnitt positive Ergebnisse. Kognitiv-verhaltenstherapeutische Programme und das RNR-Modell haben die solideste Evidenzbasis, aber auch einige andere Ansätze sind erfolgversprechend. Bei Sexualtätern sind die Ergebnisse noch weniger einheitlich, insbesondere hinsichtlich der Behandlung in Gefängnissen. Bei der Umsetzung in die Praxis zeigen sich zahlreiche Einflüsse auf die Wirksamkeit, die den Programminhalt, den Kontext, die Probanden und die Methodik der Evaluation betreffen. Das „good lives model“ und das „desistance model“ erfordern kein anderes Paradigma, sondern sind gut mit dem „What-works-Ansatz“ und erweiterten RNR-Modell vereinbar. In diesem Rahmen werden 12 Vorschläge zur empirisch fundierten Weiterentwicklung der Straftäterbehandlung gemacht.
Attrition and selectivity of the NEPS starting cohorts: an overview of the past 8 years
Authors: Zinn Sabine , Würbach Ariane , Steinhauer Hans Walter , Hammon Angelina 
Published: February 2020

AbstractThis article documents the number of target persons participating in the panel surveys of the National Educational Panel Study (NEPS) as well as the number of respondents who temporarily dropout and of those leaving the panel (attrition). NEPS comprises panel surveys with six mutually exclusive starting cohorts covering the complete life span. Sample sizes, numbers of participants and temporary as well as final dropouts and participation rates are reported in detail for each wave and for subsamples, if applicable. Sample particularities, such as the conversion of temporary dropouts into final ones, are elaborated on. All figures presented are derived from the corresponding Scientific Use Files (SUFs) published by February 1, 2018. Selectivity due to attrition (i.e., final dropouts) is studied. For this purpose, we examine how attrition distorts the NEPS samples with respect to relevant design variables (such as stratification criteria) and panel member characteristics (like sex and birth year). In detail, we study the panel status of each panel member, that is being part of the panel or having dropped out finally, along all of the panel waves with respect to starting cohort and population specific characteristics. We conclude this article with some recommendations for dealing with the detected selection bias in statistical analyses.
The Way to the Rocks—Changes of Networks of Hiking Trails in Chosen Sandstone Landscapes in Poland and the Czech Republic in the Period of Political Transformation
Authors: Kołodziejczyk Krzysztof 
Published: February 2020

AbstractThe political transformation taking place in Central European countries at the turn of 1980s and 1990s influenced, among other aspects, the methods of nature protection and making it available for tourism. The changes taking place at that time have been traced in the article on the example of three sandstone landscapes, which belong to the most popular geotouristic attractions of the Czech Republic and Poland: Prachov Rocks Nature Reserve with adjacent fragments of the Bohemian Paradise Protected Landscape Area, Adršpach-Teplice Rocks National Nature Reserve and the Table Mountains National Park. These changes were analysed on the basis of transformations of the networks of hiking trails and development of other tourism facilities within the boundaries of the protected areas. Analysis covers the entire period from the end of communism (1980s) up to present days. According to the study, in the case of all analysed protected areas, the systemic transformation in Central Europe played an important role as a factor affecting the network of hiking trails. In each case, however, local factors were also important. The biggest changes occurred in the Adršpach-Teplice Rocks and the Table Mountains. In the first case, the number and distribution of visitors needed to be controlled, leading to modification of route network. The main reason of its significant reduction was to separate paid routes from those not charged. In the Table Mountains, the network was substantially developed as a consequence of the establishment of a national park there and the political changes at the turn of twentieth and twenty-first centuries which opened the border zone and forced the marking of new tourist trails. In the Prachov Rocks, the existing layout of hiking trails has been largely kept unchanged because the continuous intensive tourist traffic did not allow any reductions, even if these would help to protect the environment. On the other hand, the network was really well developed, that it did not require further growth. Today’s networks of tourist trails in the Prachov Rocks and some parts of the Table Mountains seem too developed, taking into account the protective regime of both areas. In terms of interpretation of geoheritage, the most extensive and targeted offer can be found in the Table Mountains National Park. Referring to the methods used, the graph theory cannot be applied easily to tourist trails networks, especially when a dissected landscape is analysed. A simple but very helpful indicator illustrating the development of the network is the density of tourist trails per square kilometre.
Pediatric somatization in the emergency department: assessing missed opportunities for early management
Authors: Virk Punit , Vo Dzung X. , Ellis Jacob , Doan Quynh 
Published: February 2020

ABSTRACTObjectiveSomatization is a common phenomenon that can severely complicate youths’ functioning and health. The burden of somatization on pediatric acute care settings is currently unclear; better understanding it may address challenges clinicians experience in effectively caring for somatizing patients. In this study, we estimate the prevalence of somatization in a pediatric emergency department (ED).MethodsWe conducted a retrospective cross-sectional study of visits for non-critical, non-mental health-related concerns (n = 150) to a quaternary-level pediatric ED between July 2016 and August 2017. Demographic and clinical visit details were collected through chart review and used by two reviewing clinicians to classify whether each visit had a “probable,” “unclear” (possible), or “unlikely” somatizing component.ResultsApproximately 3.33% (n = 5) of youth displayed probable somatization, and an additional 13.33% (n = 20) possibly experienced a somatizing component but require additional psychosocial and visit documentation to be certain. Longer symptom duration and multiple negative diagnostic tests were associated with a higher likelihood of either probable or possible somatization.ConclusionsA considerable proportion of non-mental health-related visits may involve a somatizing component, indicating the burden of mental health concerns on the ED may be underestimated. A higher index of suspicion for the possibility of somatization may support clinicians in managing somatizing patients.
The Ban on Strike Action by Career Civil Servants under the German Basic Law: How the Federal Constitutional Court Constitutionally Immunized the German Legal Order Against the European Convention on Human Rights
Authors: Jacobs Matthias , Payandeh Mehrdad 
Published: February 2020

AbstractThe Federal Constitutional Court has decided that the prohibition to strike for career civil servants, as it has traditionally been part of the German legal order, is in compliance with the German Constitution. The Court thereby put a (provisional) end to a long-lasting debate on how to solve the tension between the fundamental freedom to form associations under Article 9(3) of the Basic Law, which arguably encompasses a right to strike, and Article 33(5) of the Basic Law, which protects the traditional principles of the career civil servants, which arguably encompasses the prohibition to strike. Through recognizing that the ban on strike action by career civil servants is not only allowed but required under the German Constitution, the Constitutional Court navigates the German legal order on a potential collision course with the European Convention on Human Rights and the European Court of Human Rights. In this context, the Constitutional Court on the one hand reaffirms the openness of the German constitutional order towards international law in general and human rights and the European Convention on Human Rights in particular. On the other hand, the Court somehow marginalizes the role of the European Court of Human Rights and threatens to not follow the Court should it hold that the European Convention on Human Rights demands a right to strike also for career civil servants.