bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standards-Based Clinical Decision Support Platform to Manage Patients Who Meet Guideline-Based Criteria for Genetic Evaluation of Familial Cancer
Authors: Del Fiol Guilherme , Kohlmann Wendy , Bradshaw Richard L. , Weir Charlene R. , Flynn Michael , Hess Rachel , Schiffman Joshua D. , Nanjo Claude , Kawamoto Kensaku 
Published: January 2020

PURPOSE The ubiquitous adoption of electronic health records (EHRs) with family health history (FHH) data provides opportunities for tailoring cancer screening strategies to individuals. We aimed to enable a standards-based clinical decision support (CDS) platform for identifying and managing patients who meet guidelines for genetic evaluation of hereditary cancer. METHODS The CDS platform ( www.opencds.org ) was used to implement algorithms based on the 2018 National Comprehensive Cancer Network guidelines for genetic evaluation of hereditary breast/ovarian and colorectal cancer. The platform was designed to be interfaced with different EHR systems via the Health Level Seven International Fast Healthcare Interoperability Resources standard. The platform was integrated with the Epic EHR and evaluated in a pilot study at an academic health care system. RESULTS The CDS platform was executed against a target population of 143,012 patients; 5,245 (3.7%) met criteria for genetic evaluation based on the FHH recorded in the EHR. In a clinical pilot study, genetic counselors attempted to reach out to 71 of the patients. Of those patients, 25 (35%) scheduled an appointment, 10 (14%) declined, 2 (3%) did not need genetic counseling, 7 (10%) said they would consider it in the future, and 27 (38%) were unreachable. To date, 13 (52%) of the scheduled patients completed visits, and 2 (15%) of those were found to have pathogenic variants in cancer predisposition genes. CONCLUSION A standards-based CDS platform integrated with EHR systems is a promising population-based approach to identify patients who are appropriate candidates for genetic evaluation of hereditary cancers.
Brain Differences in the Prefrontal Cortex, Amygdala, and Hippocampus in Youth with Congenital Adrenal Hyperplasia
Authors: Herting Megan M , Azad Anisa , Kim Robert , Tyszka J Michael , Geffner Mitchell E , Kim Mimi S 
Published: January 2020

Abstract

Context
Classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency results in hormone imbalances present both prenatally and postnatally that may impact the developing brain.

Objective
To characterize gray matter morphology in the prefrontal cortex and subregion volumes of the amygdala and hippocampus in youth with CAH as compared to controls.

Design
A cross-sectional study of 27 CAH youth (16 female; 12.6 ± 3.4 years) and 35 typically developing, healthy controls (20 female; 13.0 ± 2.8 years) with 3-T magnetic resonance imaging scans. Brain volumes of interest included bilateral prefrontal cortex and 9 amygdala and 6 hippocampal subregions. Between-subject effects of group (CAH vs. control) and sex, and their interaction (group-by-sex) on brain volumes, were studied while controlling for intracranial volume (ICV) and group differences in body mass index and bone age.

Results
Congenital adrenal hyperplasia youth had smaller ICV and increased cerebrospinal fluid volume compared to controls. In fully-adjusted models, CAH youth had smaller bilateral superior and caudal middle frontal volumes, and smaller left lateral orbitofrontal volumes compared to controls. Medial temporal lobe analyses revealed that the left hippocampus was smaller in fully-adjusted models. Congenital adrenal hyperplasia youth also had significantly smaller lateral nucleus of the amygdala and hippocampal subiculum and CA1 subregions.

Conclusions
This study replicates previous findings of smaller medial temporal lobe volumes in CAH patients and suggests that the lateral nucleus of the amygdala, as well as subiculum and subfield CA1 of the hippocampus, are particularly affected within the medial temporal lobes in CAH youth.
Comparison of two methods of hue scaling
Authors: Matera Courtney N. , Emery Kara J. , Volbrecht Vicki J. , Vemuri Kavita , Kay Paul , Webster Michael A. 
Published: January 2020

Hue-scaling functions are designed to characterize color appearance by assessing the relative strength of the red versus green and blue versus yellow opponent sensations comprising different hues. However, these judgments can be non-intuitive and may pose difficulties for measurement and analysis. We explored an alternative scaling method based on positioning a dial to represent the relative similarity or distance of each hue from the labeled positions for the opponent categories. The hue-scaling and hue-similarity rating methods were compared for 28 observers. Settings on both tasks were comparable though the similarity ratings showed less inter-observer variability and weaker categorical bias, suggesting that these categorical biases may reflect properties of the task rather than the percepts. Alternatively, properties that are concordant for the two paradigms provide evidence for characteristics that do reflect color appearance. Individual differences on both tasks suggest that color appearance depends on multiple, narrowly tuned color processes, which are inconsistent with conventional color-opponent theory.
SOCIAL SOLIDARITY OF STUDENTS IN STATE SMA KUPANG CITY
Authors: Toineno Fespy oristo 
Published: January 2020

SOCIAL SOLIDARITY OF STUDENTS IN STATE SMA KUPANG CITY

Fespy O. Toineno, S.Pd, Prof. Dr. Muhammad Akhyar, M.Pd, Prof. Dr. Nunuk Suryani, M.Pd
Email: 1 fespyoristo@yahoo.com, 2 makhaliya@yahoo.com, 3 nunuk_suryani_uns@yahoo.com
History Education Postgraduate Program, Sebelas Maret State University Surakarta

ABSTRACT
Social solidarity is the togetherness of individuals or groups that arise from moral feelings and shared beliefs that are reinforced by shared emotional experiences. Durkheim in Maliki said, there are two social solidarity namely mechanical solidarity and organic solidarity. Mechanical solidarity is an individual's awareness in carrying out social life based on the foundation of identity among its members. Whereas organic solidarity is an awareness developed on the basis of social cohesion through different solidarity models within the class of its members.
This research uses descriptive qualitative method, research location in the city of Kupang. Data collection is done through library research, observation, in-depth interviews, and documentation techniques. The informants in this study were students of the State Senior High School in Kupang. Data analysis techniques used in this study were by means of data collection, data reduction, data presentation and drawing conclusions.
The results showed that organic social solidarity was quite prominent in students. In the process of student social interaction, organic solidarity is more prominent. This is seen through one of the student activities in the learning process such as the division of study groups. The behavior of choosing friends according to liking, emotional closeness is very prominent. While the division of student roles is going well, but individuality or competition in groups and competition with other groups of students is inevitable.
Keywords: Solidarity, Social, Students, Schools
Feeling of Safety among Residents in Metropolitan Lagos, Nigeria
Authors: ADEJOH PIUS 
Published: January 2020

Abstract
This study examines the social factors that underpin the feeling of safety among residents in metropolitan Lagos. The paper is anchored on the instrumental and expressive theories of fear of crime and feeling of safety. It utilized quantitative data that were generated from 1,107 community members aged 18 who were drawn from four Local Government Areas of Lagos state. The study found a strong positive association between sex, employment, ethnicity, income; perceived neighbourhood crime level, experience of victimization, neighbourhood disorderliness and feeling of safety.It was recommended that relevant agencies of government-the police especially, must strive harder to improve citizens’ feeling of safety, because of its profound implications for the flourishing of democracy, economic development, social capital, associational life and the quality of life.
Suicide as a social dilemma: Evidence from Pakistan
Authors: Ahmed Zubair , Bhati Ilyas , Kausar Rizwana 
Published: January 2020

Abstract
Suicide is one of the major causes of death around the globe. It has become sensitive and imperative anthropological, psychological and public health issue which need to be tackled. The present paper provides an overview of the growing literature on suicide or more commonly known as “attempted suicide or completed suicide”. Suicidal attempts (and /or completed suicides) are increasing in urban and rural areas of Pakistan such as Karachi, Ghizer, and Hunza. The exact reasons are indefinite. This paper focuses on existing literature 1) the concept of suicide; 2) analyzes the existing consensus/figures of suicide in Pakistan; 3) analyzes the main determinants; 4) risk factors of suicide; 5) analyzes the modes of suicide discussed in the existing literature on suicides in Pakistan; and 6) offers literature gap and limitations of the evidences. It has revealed that the exact factors of socio-cultural and economical determinants of suicide in rural and urban areas were investigated paradoxically due to lack of meticulous quantitative and qualitative research. Majority studies focused on suicide in women but not even a single study focused on underlying factors of suicide in men. Further methodical studies are suggested at the community level.
Keywords: evidence, Pakistan, social dilemma, suicide, women
On the existence of non-flat profiles for a Bernoulli free boundary problem
Authors: Gravina Giovanni , Leoni Giovanni 
Published: January 2020

Abstract
In this paper, we consider a large class of Bernoulli-type free boundary problems with mixed periodic-Dirichlet boundary conditions.
We show that solutions with non-flat profile can be found variationally as global minimizers of the classical Alt–Caffarelli energy functional.
Intelligibility in Chinese English Spoken in Central China
Authors: Zhou Weijing , Deterding David , Nolan Francis 
Published: January 2020

Abstract
It is widely accepted nowadays that intelligibility is the essential goal for most learners of English, and it is not necessary for them to mimic all aspects of native-speaker English in order to achieve a high level of intelligibility. However, the features that are needed in order to make oneself easily understood by listeners from elsewhere remain controversial. The current research focuses on thirteen five-minute recordings of conversations between young speakers of English in central China and an interviewer from Britain, in order to determine which features of their speech gave rise to misunderstandings. It was found that, in the 18 tokens of misunderstanding identified, 4 resulted from lexical semantics (22%), 3 from Chinese place names (17%), 3 from grammar (17%) , and 11 from pronunciation (61%) (with some tokens cross-classified). The most common phonological factors giving rise to loss of intelligibility were omission of syllables and simplification of word-initial consonant clusters.
NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4
Authors: Li Yanhui , Guo Wei , Cai Yeping 
Published: January 2020

Abstract

Background
The inflammatory response of macrophages is responsible for sepsis. Long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to be involved in sepsis development. However, its underlying mechanism remains largely unclear. This study aims to investigate the effect of NEAT1 on inflammatory response of macrophages and explore the regulatory network of NEAT1/microRNA-17-5p (miR-17-5p)/Toll-like receptor 4 (TLR4).

Methods
The serum samples of 68 sepsis patients and 32 heathy controls were collected. THP-1 macrophages were treated with lipopolysaccharide (LPS) to induce inflammatory injury model of sepsis. The expressions of NEAT1, miR-17-5p and TLR4 were measured by quantitative real-time polymerase chain reaction or western blot. The inflammatory response was investigated by levels of inflammatory cytokines, tumor necrosis factor-alpha (TNF-ɑ), interleukin-1beta (IL-1β) and IL-6 as well as nitric oxide (NO) production. The interaction among NEAT1, miR-17-5p and TLR4 were investigated by bioinformatics analysis, luciferase reporter assay and RNA pull-down.

Results
NEAT1 expression was enhanced in patient serum and associated with severity of sepsis. Knockdown of NEAT1 inhibited levels of TNF-ɑ, IL-1β, IL-6 and NO release in LPS-treated macrophages. miR-17-5p is bound to NEAT1 and its abrogation reversed NEAT1 knockdown-mediated inhibition of inflammatory response in LPS-treated macrophages. Overexpression of miR-17-5p weakened LPS-induced inflammatory response. TLR4 as a target of miR-17-5p was regulated by NEAT1 and miR-17-5p. TLR4 res-to ration alleviated silencing NEAT1-induced inflammatory suppression.

Conclusion
Silence of NEAT1 suppressed LPS-induced inflammatory response of macrophages by mediating miR-17-5p and TLR4, indicating that NEAT1 might be a promising target for sepsis treatment.
Laboratory Investigation into the Effect of Particle Sizes on Shear Wave Parameters Using Bender Elements Test Results
Authors: Sharifi Abolhasan , Sharifipour Mohammad , Rizvandy Amir 
Published: January 2020

Abstract
Evaluating the influences of soil particle size on the dynamic behavior of soils during wave propagation has been an important issue in geotechnical engineering. Heretofore, the effects of particle size on shear wave velocities in soils have been examined using various experimental techniques. Most research in this regard so far have been carried out over a limited range of particle sizes, and the results have indicated contrasting effects of particle size on shear wave velocity (Vs). However, there has not been a comprehensive and unambiguous outcome describing the influences of particle size on Vs in soils. This research aims to experimentally investigate the effects of a wider range of particle sizes on Vs, wave shape, and frequency content of the shear waves transmitted in soil specimens. To this aim, a bender element apparatus embedded in a triaxial cell were used to minutely measure shear wave parameters of ten groups of local dry sandy soils, R1 (d50 = 0.225 mm) to R10 (d50 = 7.14 mm) samples. Moreover, dry tamping methods were employed to provide comparable samples at a similar initial void ratio of 0.8. Various amounts of frequency (5–12 kHz) and various confining pressures (50–500 kPa) were conducted on the identically prepared clean sand samples. Based on the results, it was observed that, for samples with mean particle sizes between 0.225 mm (R1) and 1.290 mm (R6), the Vs increased with the particle diameter, but for samples with mean particle sizes between 1.290 mm (R6) and 7.140 mm (R10), an increment in the particle diameter caused the Vs to decrease. It can be inferred that particle size influences the shape of the received signals such that the frequency content of the received signals, in both fine- and coarse-grained soils, are quite similar; however, medium-sized soils have a higher frequency content and a higher Vs, as well.
Optogenetic Activation of the Basolateral Amygdala Promotes Both Appetitive Conditioning and the Instrumental Pursuit of Reward Cues
Authors: Servonnet Alice , Hernandez Giovanni , El Hage Cynthia , Rompré Pierre-Paul , Samaha Anne-Noël 
Published: January 2020

Reward-associated stimuli can both evoke conditioned responses and acquire reinforcing properties in their own right, becoming avidly pursued. Such conditioned stimuli (CS) can guide reward-seeking behavior in adaptive (e.g., locating food) and maladaptive (e.g., binge eating) ways. The basolateral amygdala (BLA) regulates conditioned responses evoked by appetitive CS, but less is known about how the BLA contributes to the instrumental pursuit of CS. Here we studied the influence of BLA neuron activity on both behavioral effects. Water-restricted male rats learned to associate a light-tone cue (CS) with water delivery into a port. During these Pavlovian conditioning sessions, we paired CS presentations with photo-stimulation of channelrhodopsin-2 (ChR2)-expressing BLA neurons. BLA photo-stimulation potentiated CS-evoked port entries during conditioning, indicating enhanced conditioned approach and appetitive conditioning. Next, new rats received Pavlovian conditioning without photo-stimulation. These rats then received instrumental conditioning sessions where they could press an inactive lever or an active lever that produced CS presentation, without water delivery. Rats pressed more on the active versus inactive lever, and pairing CS presentation with BLA-ChR2 photo-stimulation intensified responding for the CS. This suggests that BLA-ChR2 photo-stimulation enhanced CS incentive value. In a separate experiment, rats did not reliably self-administer BLA-ChR2 stimulations, suggesting that BLA neurons do not carry a primary reward signal. Last, intra-BLA infusions ofd-amphetamine also intensified lever-pressing for the CS. The findings suggest that BLA-mediated activity facilitates CS control over behavior by enhancing both appetitive Pavlovian conditioning and instrumental pursuit of CS.SIGNIFICANCE STATEMENTCues paired with rewards can guide animals to valuable resources such as food. Cues can also promote dysfunctional reward-seeking behavior, as in overeating. Reward-paired cues influence reward seeking through two major mechanisms. First, reward-paired cues evoke conditioned anticipatory behaviors to prepare for impending rewards. Second, reward-paired cues are powerful motivators and they can evoke pursuit in their own right. Here we show that increasing neural activity in the basolateral amygdala enhances both conditioned anticipatory behaviors and pursuit of reward-paired cues. The basolateral amygdala therefore facilitates cue-induced control over behavior by both increasing anticipation of impending rewards and making reward cues more attractive.
PEMETAAN LAHAN PERTANIAN MENGGUNAKAN SISTEM INFORMASI GEOGRAFI (SIG) TERHADAP TINGKAT KETAHANAN PANGAN DI KABUPATEN INDRAMAYU
Authors: Syaripulloh Syaripulloh , Munandar Imam , Purwanto Iwan , Masruroh Masruroh 
Published: January 2020

Abstract. Meeting the needs of the diverse agricultural sector from various agricultural subsectors is a challenge for the government at this time, mapping of food security must be applied to overcome these problems. As for the indicators of the level of food security according to the FSVA (A Food Security and Vulnerability Atlas) of Indonesia 2015, live below the poverty line, Percentage of villages with inadequate access to links, Percentage of households without access to electricity, Percentage of women over 15 years who cannot read or write, Percentage of households without access to clean water, Percentage of villages with distance greater than 5 km from health facilities, Toddlers with poor nutrition, Life expectancy at birth, this must be fully supported by various parties. The role of GIS applications in the analysis of food security levels is in the processing of data indicators / parameters of the level of food security overlapped into a map of food security levels. The purpose of this study was to analyze the dominant factors of food security parameters that affect the level of food security in Indramayu Regency.Abstrak. Pemenuhan kebutuhan dari sektor pertanian yang beranega ragam dari berbagai subsektor pertanian menjadi tantangan pemerintah saat ini, pemetaan ketahanan pangan harus diterapkan guna mengatasi masalah tersebut adapun indikator tingkat ketahanan pangan menurut FSVA (A Food Security and Vulnerability Atlas) of Indonesia 2015 adalah, Persentase penduduk yang hidup di bawah garis kemiskinan, Persentase desa dengan akses penghubung yang kurang memadai, Persentase rumah tangga tanpa akses listrik, Persentase perempuan di atas 15 tahun yang tidak dapat membaca atau menulis, Persentase rumah tangga tanpa akses ke air bersih, Persentase desa dengan jarak lebih dari 5 km dari fasilitas kesehatan, Balita dengan gizi buruk, Angka harapan hidup pada saat lahir, hal ini harus didukung sepenuhnya oleh berbagai pihak. Peran aplikasi SIG dalam analisis tingkat ketahanan pangan yaitu dalam pengolahan data indikator/parameter tingkat ketahanan pangan yang ditumpang susunkan (overlay) menjadi peta tingkat ketahanan pangan. Tujuan penelitian ini untuk menganalisis faktor dominan dari parameter ketahanan pangan yang mempengaruhi tingkat ketahanan pangan di Kabupaten Indramayu.
Enhancement of diamond seeding on aluminum nitride dielectric by electrostatic adsorption for GaN-on-diamond preparation
Authors: Jia Xin , Wei Jun-jun , Huang Yabo , Shao Siwu , An Kang , Kong Yuechan , Wu Lishu , Qi Zhina , Liu Jinlong , Chen Liangxian , Li Chengming 
Published: January 2020

Abstract
ASPECTOS AMBIENTAIS DAS ÁREAS SUSCEPTÍVEIS À DESERTIFICAÇÃO E CARACTERÍSTICAS SOCIOAMBIENTAIS DO NÚCLEO DE DESERTIFICAÇÃO DO SERIDÓ DO RIO GRANDE DO NORTE (RN) E PARAÍBA (PB)
Authors: Lucena Marcelo Silva de 
Published: January 2020

Apesar da relevância, as discussões e a disseminação de informações, a execução de medidas para o enfretamento da desertificação praticamente não têm sido executadas. Neste sentido, este trabalho visa apresentar uma síntese de informações sobre os aspectos ambientais das áreas susceptíveis à desertificação no Semiárido brasileiro e apresentar as características socioambientais relacionadas mais diretamente com a desertificação no Seridó do Rio Grande do Norte e Paraíba. Para tal, foi realizada pesquisa onde se efetuou consulta a livros, documentos institucionais, periódicos especializados, artigos científicos e acesso a bancos de dados, por meio de expressões em português que dissessem respeito à desertificação, áreas susceptíveis à desertificação, núcleo de desertificação e núcleo de desertificação do Seridó. Constatou-se que as ASD, no Brasil, ocupam 1.340.000 km2, sendo a região semiárida sua principal integrante. Nas ASD, predominam índices pluviométricos abaixo de 800 mm, com alta evapotranspiração potencial. Os solos, com longa ocupação humana e sensibilidade à erosão de moderada a alta, apresentam os seguintes níveis de degradação: 40,80% “moderado”; 27,68% “grave” e 5,86% “muito grave”. A Caatinga é bioma predominante, onde 46,4% do território apresentam-se antropizados. No Seridó RN/PB, as implicações das atividades econômicas predominantes, caracterizadas por intensa extração de lenha, para utilização na indústria ceramista e em pequenas indústrias urbanas, e pela utilização crescente das terras, antes voltadas à agricultura, para a produção pecuária, estão forjando um quadro de degradação ambiental, requerendo, em função de suas características naturais, um modelo de aproveitamento econômico adequado às condições semiáridas.