bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction
Authors: Dalos Daniel , Binder Christina , Duca Franz , Aschauer Stefan , Kammerlander Andreas , Hengstenberg Christian , Mascherbauer Julia , Reiberger Thomas , Bonderman Diana 
Published: December 2019

AbstractPrevious studies suggested an association between heart failure (HF) and hepatic disorders. Liver function parameters have been shown to predict outcome in HF with reduced ejection fraction, but their impact in HF with preserved ejection fraction (HFpEF) has not yet been investigated. Between January 2011 and February 2017, 274 patients with confirmed HFpEF were enrolled (age 71.3 ± 8.4 years, 69.3% female) in a prospective registry. During a median follow-up of 21.5 ± 18.6 months, 97 patients (35.4%) reached the combined endpoint defined as hospitalization due to HF and/ or death from any cause. By multivariable cox regression, serum gamma-glutamyltransferase (GT) was independently associated with outcome (Hazard Ratio (HR) 1.002, p = 0.004) along with N-terminal pro brain natriuretic peptide (HR 2.213, p = 0.001) and hemoglobin (HR 0.840, p = 0.006). Kaplan-Meier analysis showed that patients with serum gamma-GT levels above a median of 36 U/L had significantly more events as compared to the remainder of the group (log-rank p = 0.012). By multivariable logistic regression, higher early mitral inflow velocity/ mitral peak velocity of late filling (Odds Ratio (OR) 2.173, p = 0.024), higher right atrial (RA) pressure (OR 1.139, p < 0.001) and larger RA diameter (OR 1.070, p = 0.001) were independently associated with serum gamma-GT > 36 U/L. Serum levels of gamma-GT are associated with both left and right-sided cardiac alterations and may serve as a simple tool for risk prediction in HFpEF, especially when further diagnostic modalities are not available.
Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis
Authors: Watanabe Shinichi , Kawakami Yukinobu , Kimura Hiroshi , Murakami Shinobu , Miyamoto Hitoshi , Takatori Shingo , Suemori Koichiro , Tanaka Mamoru , Tanaka Akihiro , Tanaka Keiko , Tauchi Hisamichi , Maki Jun , Araki Hiroaki , Yamaguchi Takumi 
Published: December 2019

AbstractStaphylococcus epidermidis infections are a common occurrence in hospitals, particularly in catheter-related bloodstream and surgical site infections and infective endocarditis. Higher daptomycin minimum inhibitory concentration (MIC) values may be associated with daptomycin treatment failure among patients with S. epidermidis infections. We therefore conducted a retrospective cohort study to determine the predictive value of daptomycin susceptibility. A retrospective study was undertaken in 1,337 patients with S. epidermidis infections. Data were collected from 1 January 2013 to 31 December 2016 at Ehime University Hospital, and included the following clinicopathological factors for evaluation: age, sex, resistance to vancomycin or teicoplanin, and history of antimicrobial therapy. Multiple analysis was performed using logistic regression to identify factors that independently and significantly affected the daptomycin resistance. Daptomycin-resistant S. epidermidis was identified in 38 (2.8%) patients. According to the multiple analysis, only higher MIC values (≥16 mg/L) for teicoplanin (P < 0.0001) were independently associated with an increased risk of developing daptomycin resistance. In conclusion, higher teicoplanin MIC values may predict resistance to daptomycin treatment in S. epidermidis infections.
Inductorless CTLE for 20 Gb/s SerDes for 5G backhaul
Authors: Gaggatur J.S. , Thulasiraman D. 
Published: December 2019

A low‐power 3‐stage continuous time linear equalisation (CTLE) was designed in 28 nm CMOS technology for a high speed SerDes in a 5G backhaul. The CTLE active inductor is a transconductance‐based, for high‐frequency operation and for area reduction. The active inductor can be tuned around 10 GHz while consuming 11.17 mW from 0.9 V power supply. The CTLE compensates about 19.5 dB of attenuation due to the channel at a data rate of 20 Gb/s per link, with a power efficiency of 18.6 fJ/bit/dB, which is better power efficiency than the previous works reported in the literature.
Focal length of a low permittivity plano‐convex lens at frequencies 30–600 GHz
Authors: Kokkonen M. , Myllymäki S. , Jantunen H. 
Published: December 2019

Due to interest in lenses at telecommunicatons in the lower frequency range of 30–600 GHz (5G/6G applications) sub‐terahertz range lenses have started to make their appearance. Geometrical optics is typically used due to its faster calculation speed, which is faster than finite element methods (FEMs). A 30‐mm plano‐convex lens was simulated with a COMSOL ray tracing module and CST was used to simulate 30, 60, 300 and 600 GHz FEM simulations. Focal points were 248, 189, 180, 118 and 131 mm with CST and 253 mm with COMSOL.
Update zur bildgebenden Diagnostik bei Patienten mit Großgefäßvaskulitis
Authors: Klink Thorsten , Bley Thorsten A. 
Published: December 2019

ZusammenfassungDie Großgefäßvaskulitis umfasst die häufigere und oft bei älteren Patienten vorkommende Riesenzellarteriitis und die häufiger bei jüngeren Patientinnen auftretende Takayasu-Arteriitis. Die Bildgebung ist bei diesen Vaskulitiden sowohl für die Primärdiagnostik als auch bei Folgeuntersuchungen wichtig und wird im Folgenden differenziert dargestellt.
Aktuelle Aspekte der Cholesteatomchirurgie – Teil 1: Grundlagen und Diagnostik
Authors: Schulze Anja , Zahnert Thomas 
Published: December 2019

Das Cholesteatom als chronische Entzündung des Mittelohrs führt zu einer fortschreitenden knöchernen Destruktion des Felsenbeins. Leitsymptome sind fötide Otorrhö, Schwerhörigkeit und Schwindel. Unbehandelt kann das Cholesteatom durch intrakranielle Komplikationen letal verlaufen. Es folgt eine Darstellung des aktuellen und allgemein anerkannten Kenntnisstandes zur Genese, Klinik und präoperativen Diagnostik. Ausführungen zur operativen Therapie folgen in einem 2. Teil.
Verdacht auf Hippocampussklerose bei einer Europäisch-Kurzhaar-Katze mit der Diagnose Polycythaemia
vera
Authors: Kempf Jennifer , von Magnis Johannes 
Published: December 2019

ZusammenfassungBei einer 7-jährigen männlich-kastrierten Europäisch-Kurzhaar-Katze, vorgestellt aufgrund von akut reduziertem
Allgemeinbefinden und einer vestibulären Ataxie, wurde die Diagnose Polycythaemia vera gestellt. Im weiteren Verlauf
zeigte die Katze intermittierend orofaziale Zuckungen, Aggressivität, Speicheln, Kreiswandern und Kopfschiefhaltung. Bei
der weiterführenden Diagnostik mittels Magnetresonanztomografie ließen sich Veränderungen im Bereich des Hippocampus
nachweisen, die mit einer Hippocampussklerose vereinbar waren. Der Fallbericht beschreibt zum einen die klinischen und
hämatologischen Befunde einer Polyzythämie und den Krankheitsverlauf während der Therapie. Zum anderen wird der
Zusammenhang zur Hippocampusveränderung diskutiert. Diese könnte sekundär zu einer durch die Polyzythämie verursachten
zerebralen Hypoperfusion entstanden sein.
Leitfaden Ernährungstherapie in Klinik und Praxis (LEKuP)
Authors: Hauner Hans , Beyer-Reiners Evelyn , Bischoff Gert , Breidenassel Christina , Ferschke Melanie , Gebhardt Albrecht , Holzapfel Christina , Lambeck Andrea , Meteling-Eeken Marleen , Paul Claudia , Rubin Diana , Schütz Tatjana , Volkert Dorothee , Wechsler Johannes , Wolfram Günther , Adam Olaf 
Published: December 2019

ZusammenfassungDer Leitfaden Ernährungstherapie in Klinik und Praxis (LEKuP) stellt eine grundlegende Überarbeitung des zuletzt im Jahr 2004 von der Deutschen Akademie für Ernährungsmedizin e. V. (DAEM) herausgegebenen Rationalisierungsschemas dar. Dabei erfolgte die Erstellung des LEKuP in enger Zusammenarbeit der verschiedenen Fachgesellschaften: Deutsche Gesellschaft für Ernährung e. V. (DGE) und die Deutsche Akademie für Ernährungsmedizin e. V. (DAEM) mit der Deutschen Gesellschaft für Ernährungsmedizin e. V. (DGEM), dem Berufsverband Deutscher Ernährungsmediziner e. V. (BDEM), der Deutschen Adipositas-Gesellschaft e. V. (DAG), dem Verband der Diätassistenten – Deutscher Bundesverband e. V. (VDD) und dem Berufsverband Oecotrophologie e. V. (VDOE).Gemeinsames Ziel der beteiligten Fachgesellschaften und -verbände war es, auf Grundlage evidenzbasierter Leitlinien einen aktuellen und konsensbasierten Leitfaden für die praktische Ernährungstherapie in Klinik und Praxis zu verfassen. Ein weiteres Ziel der Überarbeitung war es, damit eine Vorlage zu schaffen, aus der ein Kostformenkatalog für stationäre und ambulante medizinische Einrichtungen nach den lokalen Bedürfnissen abgeleitet werden kann.Die dem LEKuP zugrunde liegenden Empfehlungen basieren auf den D-A-CH-Referenzwerten für die Nährstoffzufuhr der Deutschen Gesellschaft für Ernährung e. V. (DGE) für Erwachsene und entsprechen einer vollwertigen und gesundheitsförderlichen Ernährung. Mittelmeerkost und vegetarische Ernährung werden als gleichwertig betrachtet. Abhängig von krankheitsspezifischen Erfordernissen werden Abweichungen und Ergänzungen vorgenommen, sodass eine Ernährungstherapie umgesetzt werden kann, die alle ernährungsbezogenen Maßnahmen zur Wiederherstellung von Gesundheit und Wiedererlangung des Handlungsvermögens von Patienten darstellt. Der vorliegende Leitfaden beschränkt sich auf die Darstellung der Prinzipien der Ernährungstherapie und deren praktische Umsetzung.
Effektivität von topischem Oclacitinib mit und ohne Tacrolismus bei kaniner Keratoconjunctivitis
sicca
Authors: Betz Daniela Simon 
Published: December 2019

Kravetz de Oliveira J, Williams DL, Bollmann C et al. Comparative efficacy of topical oclacitinib 0.1 % and tacrolimus
0.01 % in canine keratoconjunctivitis sicca. Vet Ophthalmol 2019; 22: 633–643
Keratoconjunctivitis sicca (KCS) ist eine meist autoimmun bedingte Erkrankung des Hundes, die mit einer entzündlichen
Infiltration und nachfolgender Atrophie der Tränendrüsen einhergeht. Hierdurch kommt es zu einer Reduktion der
Tränenproduktion mit chronischer Entzündung des Auges und entsprechendem negativem Einfluss auf die Lebensqualität
der Patienten. Ziel dieser Studie war, die Effektivität des Oclacitinib (ein für die Behandlung von
allergiebedingtem Juckreiz zugelassener Januskinase-Inhibitor) allein oder in Kombination mit der klassischen
immunmodulatorischen Therapie mit Tacrolismus zu untersuchen.
Sportliche Leistung von Pferden, die als Fohlen intensivmedizinischer Behandlung
bedurften
Authors: Demattio Lukas 
Published: December 2019

Studies AC, Chidlow H, Ere SG et al. Factors associated with long-term athletic outcome in Thoroughbred neonates admitted
to an intensive care unit. Equine Vet J 2019; 51: 716–719
Für viele Pferdezüchter stellt sich immer wieder die Frage, wie viel Geld in ein Fohlen investiert werden soll, wenn
dieses tierärztlicher Behandlung bedarf. Lohnt sich eine intensivmedizinische Behandlung für ein Fohlen, das für
eine sportliche Nutzung vorgesehen ist? Diese Frage versuchten die Autoren in der Studie zu beantworten.
Endoskopische Vasektomie beim Hengst
Authors: Nieth Jennifer 
Published: December 2019

Vitoria A, Romero A, Fuenta S et al. Application of a laparoscopic technique for vasectomy in standing horses. Vet Rec
201; 185 (11): 345
Bei der Vasektomie wird der Ductus deferens abgebunden und ein Anteil entfernt. Es resultiert eine Azoospermie bei
Erhaltung des hormonell bedingten Verhaltens und der Auswirkungen auf die körperliche Entwicklung. Dieser Eingriff
ist als konventionell chirurgische und als minimalinvasiv endoskopische Operationsmethode in der Humanmedizin
verbreitet und in der Tiermedizin bei verschiedenen Spezies beschrieben. Ziel der Studie war, diesen Eingriff beim
Pferd erstmals zu beschreiben und ihren Erfolg zu bewerten.
Correlation between the Expression of Interleukin-6, STAT3, E-Cadherin and N-Cadherin Protein and Invasiveness in Nonfunctional Pituitary Adenomas
Authors: Shen Xiaoxu , Liu Qi , Xu Jian , Wang Yang 
Published: December 2019

Abstract
Objective This study aimed to investigate the expression of interleukin (IL)-6, signal transducer and activator of transcription 3 (STAT3), epithelial-cadherin (E- cadherin) and neural-cadherin (N-cadherin) proteins in nonfunctional pituitary adenomas, and their correlation with invasiveness.
Methods Thirty cases of nonfunctional pituitary adenoma pathological wax specimens were selected from our hospital, including 20 cases of invasive nonfunctional pituitary adenoma (INFPA) and 10 noninvasive nonfunctional pituitary adenomas (NNFPAs). Envision was used to detect IL-6, STAT3, E-cadherin , and N-cadherin in specimens. Statistical methods were used to analyze the correlation between the four proteins and the Knosp classification of nonfunctional pituitary adenomas.
Result IL-6 and STAT3 were highly expressed in INFPAs but poorly expressed in NNFPAs. E-cadherin expression in INFPAs was lower than that in NNFPAs. N-cadherin was positive or strongly positive in both groups. Spearman's correlation analysis showed that the expression of IL-6 and STAT3 was positively correlated with Knosp's classification, whereas the expression of E-cadherin was negatively correlated with Knosp classification. Meanwhile, the expression of N-cadherin was not correlated with Knosp's classification.
Conclusion The expression of the IL-6, STAT3, E-cadherin proteins were associated nonfunctional pituitary adenomas. However, the expression of N-cadherin was not correlated with nonfunctional pituitary adenomas.
Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils
Authors: Vadillo Eduardo , Chánez-Paredes Sandra , Vargas-Robles Hilda , Guerrero-Fonseca Idaira María , Castellanos-Martínez Ramón , García-Ponce Alexander , Nava Porfirio , Girón-Pérez Daniel Alberto , Santos-Argumedo Leopoldo , Schnoor Michael 
Published: December 2019

SignificanceMyosin1e is a protein regulating actin cytoskeleton functions, which has not been studied in the context of neutrophil recruitment during inflammation. Using intravital microscopy of inflamed tissue in WT and myosin1e-deficient mice, we show that absence of myosin1e inhibits neutrophil migration out of the blood stream into inflamed tissue. Neutrophils lacking myosin1e show defective actin cytoskeleton polymerization, integrin activation, and aberrant rolling behavior termed “intermittent rolling,” suggesting that myosin1e is important for strengthening adhesive interactions of neutrophils with the vascular endothelium. Our findings are significant as they highlight myosin1e as a critical regulator of inflammatory neutrophil recruitment in vivo. Thus, myosin1e could be a therapeutic target for chronic inflammatory diseases.
On numerical modelling of gas flows through axisymmetric porous object with heterogeneous combustion sources under forced filtration
Authors: Borovik K G 
Published: December 2019

Abstract
The time-dependent gas flows through axisymmetric porous objects with heterogeneous combustion sources are considered. The mathematical model, which describes the process, and the numerical method are proposed. The regimes of heterogeneous combustion wave propagation in axisymmetric porous object with various location of ignition zones under forced filtration are investigated. It is shown that the gas tends to bend around the heated zone and flows through colder regions as in the case of two-dimensional plane flows.
Physical model of a heterogeneous medium as applied to nuclear medicine
Authors: Denisova N V 
Published: December 2019

Abstract
In nuclear medicine, a patient is administered a radiolabeled pharmaceutical which is distributed in various organs of a patient body. The patient body with distributed emitting radiopharmaceutical is a heterogeneous medium. In this work, the problem of reconstructing the image of the human brain using single-photon emission tomography (SPET) is considered. To obtain the image, the statistical MAP-ENT algorithm is applied. To develop this algorithm, it is necessary to formulate a priori information about the object to be reconstructed. The distribution of radiopharmaceuticals in the patient’s body is a spatially inhomogeneous distribution of non-interacting radiopharmaceutical particles. This distribution is described using the Boltzmann model of a non-equilibrium isolated system. For such a system, one can write the entropy functional, which determines the a priori model. The algorithm was tested using the Hoffman mathematical model, which simulates the distribution of a radiopharmaceutical in the human brain. In numerical experiments, the properties of the MAP-ENT algorithm were studied under conditions close to clinical practice. The results have shown the prospects of the MAP-ENT algorithm.
The formation of heterogeneous wear-resistant coatings by the additive technology method
Authors: Golyshev A A , Malikov A G , Orishich A M 
Published: December 2019

Abstract
The microstructure, hardness property and wear resistance coatings of WC, Ni-Cr and Fe powders deposited by laser cladding at varying processing parameters were investigated. The results of the present study revealed the prospects of multilayer cladding of R6M5 high-speed tool steel (analogy of M2 steel) onto low-alloy steel with the use of a laser beam. Controlling thermal cycles of laser cladding, it is possible to obtain a clad coating made of high-speed steel having the structure of high-alloy austenite martensite mixture with disperse inclusions of carbides up to 10 mm thick, i.e., it is actually possible to create bimetal structures. The wear resistance of the laser-clad self-fluxing PG-10N-01 (Ni-Cr-B-Si-C) alloy increases by a factor of 5 due to additional hardening by cast tungsten carbide with spherical particles. As a result, it becomes higher than the wear resistance of high-speed steel by more than a factor of 3.
Study of the mechanism of attenuation of thermocapillary convection of the melt during laser powder cladding
Authors: Kovalev O B , Gurin A M 
Published: December 2019

Abstract
The results of a numerical solution of the thermocapillary microconvection problem arising under the action of laser radiation in a liquid metal during laser surface treatment are presented. A characteristic feature of the behavior of particles of refractory metals in a multi-vortex melt pool is revealed. The influence of falling powder particles in the melt on the inhibition of thermocapillary convection is estimated. The mechanisms of slowing the melt flow associated with the addition of powder components for laser alloying or cladding is discussed. The results of three-dimensional calculations are presented, which show how these mechanisms can work.
Numerical simulation of the high-speed interaction of a spherical impactor with a system of spaced heterogeneous plates
Authors: Kraus A E , Kraus E I , Shabalin I I 
Published: December 2019

Abstract
A 3D non-stationary problem of the interaction of space debris spherical particle and spaced protective screens is considered. To verify the 3D code, a series of calculations was performed of the impact of a spherical impactor made of ShKh15 steel at speed of 3.02 km/s with a spaced barrier consisting of three homogeneous plates, the first two made of AMg6 alloy and the third one made of steel 10. Comparison of the results of numerical calculations for hole diameters with experimental data showed (2-5)% compliance. The collisions of steel spheres with AMg6 plates were calculated at an angle to the normal. To compare the resistance of the protective system, homogeneous screens were replaced by plates of heterogeneous material AMg6+B4C. It was shown that with the same mass characteristics, a heterogeneous system of screens had increased resistance compared to a homogeneous system.
Justification of the asymptotic behavior of the filtration theory regimes by the method of conditional moment
Authors: Mishin A V 
Published: December 2019

Abstract
In the work, a substantiation of the filtration modes is proposed by the method of conditional moments. The Navier-Stokes stationary equation of motion is used as initial equation. The calculations within the framework of this model include the construction of a solution of stochastic equations by the Green’s function method, the subsequent conditional averaging of this solution, the direct and inverse Fourier transform in order to extract the integrals containing the structure of the medium and to obtain the desired averaged equations, respectively. At large Reynolds numbers, inertial terms dominate. When averaging them, a structural form of the quadratic filtration law is obtained. At low Reynolds numbers, the viscous terms make the main contribution, the averaging of which leads to Darcy’s law.
Numerical simulation of particle beam focusing in a supersonic nozzle with rectangular cross-section
Authors: Shershnev A A , Kudryavtsev A N 
Published: December 2019

Abstract
Particle-laden flow in 3D supersonic micronozzle with rectangular cross-section and side walls convergent/divergent in both lateral and transversal direction is studied numerically using a one-way coupled Eulerian/Lagrangian approach. The carrier gas flow is simulated numerically on the basis of the Navier-Stokes equations and then is used to calculate the particles trajectories. It is shown that a collimated beam of particles can be produced using the effect of aerodynamic focusing and the beam collimation is observed in two different ranges of particle sizes. Obtained results are consistent with previously obtained data for plane and axisymmetrical nozzles.
The effect of ball milling in a planetary mill on aluminium particles microstructure and properties of cold sprayed coatings
Authors: Vidyuk T M , Chesnokov A E , Smirnov A V , Shikalov V S 
Published: December 2019

Abstract
Cold spraying allows one to obtain coatings without significant powder particles overheating. Hence, cold sprayed coatings have properties similar to that of sprayed particles. This paper shows results of the aluminium powder preparation for cold spraying. It is demonstrated that preliminary ball milling in the high-energy mill «Activator-2SL» has a significant impact on the particles shape and its structure. The ball milled particles have layered structure containing of a variety of the ultrafine aluminium particles.
Numerical investigations of dam-break flow problem
Authors: Yakovenko S N , Yakovenko E E , Chang K C 
Published: December 2019

AbstractA dam-break flow of water above horizontal dry bottom is studied numerically, after the comprehensive review of available literature. Computation tools include different interface resolution techniques and the continuous surface tension force model. The results are compared with the measurement data. It is shown that surface tension leads to the motion suppression and, therefore, to the acceleration decrease, providing closer agreement with laboratory experiments.
Estimation of the initiation energy of detonation excited by a fast moving body
Authors: Bedarev I A , Temerbekov V M 
Published: December 2019

Abstract
The results of numerical study of the detonation initiation by small diameter spherical supersonic projectile in reacting mixture are presented. A stoichiometric hydrogen and oxygen mixture diluted with argon was used as a reacting medium. The reduced kinetic scheme of chemical reactions was used in our study. The flow regimes and the detonation cell size obtained numerically and experimentally were compared and showed good agreement. Calculations for various sphere diameters at fixed pressure were carried out. The detonation initiation energy for the calculated data was estimated.