bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation and superconducting properties of predicted ternary hydride ScYH6 under pressures
Authors: Wei Yong Kai , Jia Liang Quan , Fang Yan Yan , Wang Long Jun , Qian Zhi Xiu , Yuan Jiao Nan , Selvaraj Gurudeeban , Ji Guang Fu , Wei Dong Qing 
Published: September 2020

AbstractTernary metal hydrides play an essential role in the search for conventional high‐temperature superconductors because they can be synthesized under mild conditions and recovered at ambient pressure. It has been widely accepted that the electronic structure, metallization pressure, and superconducting behavior of binary hydrides can be adjusted effectively by doping, replacing, or introducing a new element. In this work, yttrium hydrides were chosen as parent hydrides, while scandium was considered the doping element to perform systematical crystal structure searches on the Sc‐Y‐H system under pressure. A new ternary hydride ScYH6 with a Pm‐3 structure (cP8) was found below 150 GPa according to Particle Swarm Optimization calculations, and then, a P4/mmm phase (tP8) becomes favorable from 150 GPa. Importantly, cP8‐ScYH6 is dynamically stable under pressure as low as 0.01 GPa with a superconducting temperature (Tc) of 32.110 K for Coulomb pseudopotential μ* = 0.13, indicating that ternary hydrides are promising candidates in the search for superconductors that can be synthesized under mild conditions in hydrogen‐rich materials. The analysis using the “triangle straight‐line method”, compared with enthalpy difference calculations, showed that the most reasonable synthesis pathway of ScYH6 is ScH3 + YH3 → ScYH6 in the whole pressure regime studied in this work. The Tc of ScYH6 has a linear relationship with pressure up to 52.907 K under 200 GPa. The lattice dynamical calculations demonstrate that the H atoms in both cP8 and tP8 structures make crucial contributions to the superconducting behavior of ScYH6. These findings can further reveal the influence of doping, replacing, and introducing element on the superconducting behavior of binary hydrides.
Classical potential for general spinning bodies
Authors: Chung Ming-Zhi , Huang Yu-tin , Kim Jung-Wook 
Published: September 2020

Abstract
In this paper we compute the spin-dependent terms of the gravitational potential for general spinning bodies at the leading Newton’s constant G and to all orders in spin. We utilize the on-shell approach, which extracts the classical potential directly from the scattering amplitude. For spinning particles, extra care is required due to the fact that the spin space of each particle is independent. Once the appropriate matching procedures are applied, taking the classical-spin limit we obtain the potential for general spinning bodies. When the Wilson coefficients are set to unity, we successfully reproduced the potential for the Kerr black hole. Interestingly, for finite spins, we find that the finite-spin deviations from Kerr Wilson coefficients cancel with that in the matching procedure, reproducing the Kerr potential without the need for taking the classical-spin limit. Finally, we find that when cast into the chiral basis, the spin-dependence of minimal coupling exhibits factorization, allowing us to take the classical-spin limit straight forwardly.
Adinkra foundation of component decomposition and the scan for superconformal multiplets in 11D, $$ \mathcal{N} $$ = 1 superspace
Authors: James Gates S. , Hu Yangrui , Mak S.-N. Hazel 
Published: September 2020

Abstract
For the first time in the physics literature, the Lorentz representations of all 2,147,483,648 bosonic degrees of freedom and 2,147,483,648 fermionic degrees of freedom in an unconstrained eleven dimensional scalar superfield are presented. Comparisons of the conceptual bases for this advance in terms of component field, superfield, and adinkra arguments, respectively, are made. These highlight the computational efficiency of the adinkra-based approach over the others. It is noted at level sixteen in the 11D, $$ \mathcal{N} $$
N
= 1 scalar superfield, the {65} representation of SO(1,10), the conformal graviton, is present. Thus, adinkra-based arguments suggest the surprising possibility that the 11D, $$ \mathcal{N} $$
N
= 1 scalar superfield alone might describe a Poincaré supergravity prepotential or semi-prepotential in analogy to one of the off-shell versions of 4D, $$ \mathcal{N} $$
N
= 1 superfield supergravity. We find the 11D, $$ \mathcal{N} $$
N
= 1 scalar superfield contains 1,494 bosonic fields, 1,186 fermionic fields, and a maximum number of 29,334 links connecting them via orbits of the supercharges.
Integrated computational product and production engineering for multi-material lightweight structures
Authors: Hürkamp André , Dér Antal , Gellrich Sebastian , Ossowski Tim , Lorenz Ralf , Behrens Bernd-Arno , Herrmann Christoph , Dröder Klaus , Thiede Sebastian 
Published: September 2020

AbstractWithin product development processes, computational models are used with increasing frequency. However, the use of those methods is often restricted to the area of focus, where product design, manufacturing process, and process chain simulations are regarded independently. In the use case of multi-material lightweight structures, the desired products have to meet several requirements regarding structural performance, weight, costs, and environment. Hence, manufacturing-related effects on the product as well as on costs and environment have to be considered in very early phases of the product development process in order to provide a computational concept that supports concurrent engineering. In this contribution, we present an integrated computational concept that includes product engineering and production engineering. In a multi-scale framework, it combines detailed finite element analyses of products and their related production process with process chain and factory simulations. Including surrogate models based on machine learning, a fast evaluation of production impacts and requirements can be realized. The proposed integrated computational product and production engineering concept is demonstrated in a use case study on the manufacturing of a multi-material structure. Within this study, a sheet metal forming process in combination with an injection molding process of short fiber reinforced plastics is investigated. Different sets of process parameters are evaluated virtually in terms of resulting structural properties, cycle times, and environmental impacts.
In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta
Authors: Granitzer Sebastian , Ellinger Isabella , Khan Rumsha , Gelles Katharina , Widhalm Raimund , Hengstschläger Markus , Zeisler Harald , Desoye Gernot , Tupova Lenka , Ceckova Martina , Salzer Hans , Gundacker Claudia 
Published: September 2020

AbstractMethyl mercury (MeHg) is an organic highly toxic compound that is transported efficiently via the human placenta. Our previous data suggest that MeHg is taken up into placental cells by amino acid transporters while mercury export from placental cells mainly involves ATP binding cassette (ABC) transporters. We hypothesized that the ABC transporter multidrug resistance-associated protein (MRP)1 (ABCC1) plays an essential role in mercury export from the human placenta. Transwell transport studies with MRP1-overexpressing Madin-Darby Canine Kidney (MDCK)II cells confirmed the function of MRP1 in polarized mercury efflux. Consistent with this, siRNA-mediated MRP1 gene knockdown in the human placental cell line HTR-8/SVneo resulted in intracellular mercury accumulation, which was associated with reduced cell viability, accompanied by increased cytotoxicity, apoptosis, and oxidative stress as determined via the glutathione (GSH) status. In addition, the many sources claiming different localization of MRP1 in the placenta required a re-evaluation of its localization in placental tissue sections by immunofluorescence microscopy using an MRP1-specific antibody that was validated in-house. Taken together, our results show that (1) MRP1 preferentially mediates apical-to-basolateral mercury transport in epithelial cells, (2) MRP1 regulates the GSH status of placental cells, (3) MRP1 function has a decisive influence on the viability of placental cells exposed to low MeHg concentrations, and (4) the in situ localization of MRP1 corresponds to mercury transport from maternal circulation to the placenta and fetus. We conclude that MRP1 protects placental cells from MeHg-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells' GSH status in equilibrium.
Ultrasound-based liver elastography: current results and future perspectives
Authors: Fang Cheng , Sidhu Paul S. 
Published: September 2020

AbstractChronic liver disease affects 185 million population worldwide. It encompasses a heterogenous disease spectrum, but all can lead to the development of liver fibrosis. The degree of liver fibrosis is not only a prognosticator, but has also been used to guide the treatment strategy and to evaluate treatment response. Traditionally, staging of liver fibrosis is determined on histological analysis using samples obtained from an invasive liver biopsy. Ultrasound-based liver elastography is a non-invasive method of assessing diffuse liver disease in patients with known chronic liver disease. The use of liver elastography has led to a significant reduction in the number of liver biopsies performed to assess the severity of liver fibrosis and a liver biopsy is now reserved for only select sub-groups of patients. The aim of this review article is to discuss the key findings and current evidence for ultrasound-based elastography in diffuse liver disease as well as the technical challenges and to evaluate the potential research direction.
Lessons from Fitting the Lowest Order Energy Independent Chiral Based $$\bar{K}N$$ Potential to Experimental Data
Authors: Révai J. 
Published: September 2020

AbstractIt is shown, that fitting parameters of a$$\bar{K}N$$K¯Ninteraction model to different sets of experimental data can lead to physical conclusions which might provide a deeper insight into the physics of this multichannel system. The available experimental data are divided into three parts: the “classical” set consisting of the low-energy$$K^-p$$K-pcross sections and the threshold branching ratios, the SIDDHARTA 1slevel shift in kaonic hydrogen and the CLAS photoproduction data. We have fitted the parameters of the potential to different combinations of these data. We found, that the two poles corresponding to the$$I=0$$I=0nuclear quasi-bound state$$(\Lambda (1405))$$(Λ(1405))and to the$$K^-p$$K-p1satomic level seem to resist to their simultaneous reproduction at the right place, though a more or less satisfactory compromise can be achieved. Potentials with the$$\Lambda (1405)$$Λ(1405)pole pinned down close to the PDG value fail to reproduce the classical two-body data with an acceptable accuracy. We also added comments on two papers criticizing the potential used in the fits.
Transarterial fiducial marker implantation for CyberKnife radiotherapy to treat pancreatic cancer: an experience with 14 cases
Authors: Imaizumi Akira , Araki Takuji , Okada Hiroki , Sasaki Yu , Komiyama Takafumi , Suzuki Toshihiro , Takahashi Hiroshi , Onishi Hiroshi 
Published: September 2020

Abstract
Purpose
The purpose of this study was to evaluate the safety and feasibility of transarterial fiducial marker implantation for CyberKnife radiotherapy to treat locally advanced pancreatic cancer.

Materials and methods
Fifteen pancreatic cancer patients were enrolled for transarterial marker implantation. Embolization platinum coils were implanted as a fiducial marker within 20 mm of the cancer edge, and preferably within 3 mm. The technical success of the implantation was defined as implantation of at least one fiducial marker within 20 mm of the target tumor. Irradiation was performed using the CyberKnife system.

Results
For 14 of 15 patients, transarterial implantation was successfully performed, and for 13 of 14 patients, the tracking marker was implanted within 3 mm of the cancer. Tracking instability was observed in two patients, but irradiation was accomplished in all 14 patients. No major complications caused by the implantation procedure were observed. The median overall survival after irradiation was 13.8 months, and the 1- and 2-years survival rates were 62.9% and 32.3%, respectively.

Conclusion
Transarterial fiducial marker implantation for pancreatic cancer can be safely performed for tracking, and it will be a valuable alternative approach to percutaneous fiducial marker implantation.
Determining the machining allowance for WAAM parts
Authors: Fuchs Christina , Baier Daniel , Semm Thomas , Zaeh Michael F. 
Published: September 2020

AbstractIn order to decrease mass, and thus fulfil the targets for airplane traffic emission reduction, the amount of titanium alloys used for structural components is rising. With the conventional milling process, low material utilization and short tool life lead to high manufacturing costs. Therefore, a process chain consisting of wire and arc additive manufacturing (WAAM) and machining is developed. To realize its full potential, the machining process needs to be adapted to the near-net shaped components. A special focus lies on the machining allowance, since it influences both processes and in result the final part quality. In this paper a method to model the machining allowance is proposed and verified by analysing the changes from waviness to surface roughness occurring during peripheral milling of WAAM parts.
Non-thermal Processing of Pineapple (Ananas comosus [L.] Merr.) Juice Using Continuous Pressure Change Technology (PCT): Effects on Physical Traits, Microbial Loads, Enzyme Activities, and Phytochemical Composition
Authors: Vollmer Kathrin , Santarelli Sara , Vásquez-Caicedo Ana Lucía , Iglesias Salima Varona , Frank Jan , Carle Reinhold , Steingass Christof Björn 
Published: September 2020

AbstractA comprehensive study using continuous pressure change technology (PCT) for the non-thermal processing of fresh pineapple juice on pilot scale was conducted (1 L/min, 50 MPa, argon, 3 min, <35 °C). The immediate effects of a single and a twofold PCT treatment on the most important quality parameters were examined and compared with those of fresh and thermally pasteurised (90 °C) juices. In comparison to the fresh juice, both PCT-treated samples exhibited slightly brighter and less yellowish colour (CIE L*a*b*). A significant reduction in the mean particle size resulted in diminished centrifugable pulp contents and enhanced cloud stability. Moreover, a slightly improved microbial quality (−0.9 to −1.2 log10 CFU/mL) in terms of total aerobic and yeast and mould counts was attained. Noteworthy, PCT retained a high bromelain activity (−3 to −15% reduction) and efficiently inactivated polyphenol oxidase. Water-soluble vitamins, phenolic compounds, and all further constituents assessed were mostly preserved. However, the high residual peroxidase activity (−10 to −23%) and microbial loads are likely to affect juice quality during storage. In contrast, thermal pasteurisation ensured a complete reduction in both microbial counts (−4.4 to −4.5 log10 CFU/mL) and effective inactivation of peroxidase. However, bromelain activity was strongly affected (−83%) by heat treatment, and colour was darkened and even less yellowish. Overall, this study highlighted the potential of PCT for the production of fresh-like pineapple juices; however, its current limitations were revealed as well.
Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma
Authors: Poma Anello Marcello , Macerola Elisabetta , Torregrossa Liborio , Elisei Rossella , Santini Ferruccio , Basolo Fulvio 
Published: September 2020

Abstract
Purpose
The 8th edition of the American Joint Committee on Cancer (AJCC) staging led to a significant downstaging of well differentiated thyroid cancer patients. However, some patients who had been downstaged still experienced death. By using data from the thyroid cancer dataset of The Cancer Genome Atlas (TCGA), we aimed to find molecular features that could improve survival prediction.

Methods
TCGA data were downloaded from cBioPortal. Restaging of cases was performed according to the pathological reports.

Results
Out of 496 cases, 204 (41.1%) were downstaged, and the proportion of deaths increased in stages III and IV. TERT promoter mutations were no longer enriched in stage IV only, but significantly redistributed also in stages II and III. TERT mutation was the only alteration predictive of poor survival; however, in this series it was not independent from the AJCC staging. Five proteins (4E-BP1_pT70, Chk1_pS345, Snail, STAT5 alpha and PAI-1) were significantly associated with survival, and their use as a panel refined the risk stratification independently from the AJCC staging, with a hazard ratio for a positive result of 21.2 (95%CI 3.7–122.2, P = 0.0006).

Conclusions
In the TCGA series, the proportion of deaths is in line with the expected survival of the latest AJCC staging, with a neat separation of risk among stages. Nevertheless, the use of protein expression can be useful in refining the stratification. Finally, after the restaging, a considerable number of tumors with TERT mutations will be allocated in lower stages; hence, dedicated studies should define the prognostic usefulness of these mutations in low-stage diseases.
Clinical features, risk of mass enlargement, and development of endocrine hyperfunction in patients with adrenal incidentalomas: a long-term follow-up study
Authors: Falcetta Pierpaolo , Orsolini Francesca , Benelli Elena , Agretti Patrizia , Vitti Paolo , Di Cosmo Caterina , Tonacchera Massimo 
Published: September 2020

Abstract
Purpose
To evaluate the risk of mass enlargement and endocrine function modification in patients with adrenal incidentaloma (AI).

Methods
In this retrospective study, we examined clinical and hormonal characteristics of 310 patients with AI (200 females and 110 males; age: 58.3 ± 12.9 years), followed up for a median (interquartile range) of 31.4 months (13.0–78.6) and evaluated for possible modification in adrenal mass size and hormonal function. The hormonal evaluation included morning serum cortisol and plasma ACTH at 8 a.m., aldosterone, plasma renin activity/direct renin concentration, and 24-h urine metanephrines/normetanephrines. One microgram overnight dexamethasone suppression test (DST) was performed. Autonomous cortisol secretion (ACS) was diagnosed in the presence of cortisol after 1 mg DST > 5 μg/dl (138 nmol/l) or >1.8 and ≤5 μg/dl (50–138 nmol/l) and at least one of the following: (i) low ACTH; (ii) increased 24-h urinary-free cortisol; (iii) absence of cortisol rhythm; and (iv) post-LDDST cortisol level > 1.8 μg/dl (50 nmol/l). When there was no biochemical evidence of adrenal hormonal hyperactivity, AIs were classified as nonfunctioning (NFAIs). The mass was considered significantly enlarged when the size increase was more than 20% and at least 5 mm compared to baseline.

Results
At diagnosis, NFAIs were found in 209 patients, while ACS and overt adrenal hyperfunction were diagnosed in 81 and 20 patients, respectively. During follow-up, 3.3% and 1.5% of patients with NFAI developed subtle and overt endocrine hyperfunction, respectively, while a significant mass enlargement was observed in 17.7% of all AIs. The risk of developing ACS was significantly higher in patients with adenoma >28 mm (hazard ratio [HR] 12.4; 95% confidence interval [CI], 2.33–66.52, P = 0.003), in those with bilateral adrenal tumors (HR: 5.36; 95% CI, 1.17–24.48, P = 0.030), and with low/suppressed ACTH values (HR: 11.2, 95% CI 2.06–60.77; P = 0.005). The risk of mass enlargement was lower for patients in the fourth quartile of body mass index than those in the first quartile (HR 0.33; 95% CI, 0.14–0.78; P = 0.012).

Conclusions
In patients with AI, the risk of developing hormonal hyperfunction and mass enlargement is overall low, although some tumor characteristics and anthropometric features might increase this risk. Taking account of all these aspects is important for planning a tailored follow-up in AI patients.
Optimization of perforated liner parameters in horizontal oil wells
Authors: Dastgerdi Milad Ebrahimi , Manshad Abbas Khaksar , Mohammadi Amir H. 
Published: September 2020

AbstractNowadays, horizontal wells play a vital role in the production from thin heavy oil reservoirs. Designing a suitable completion for this kind of reservoirs is a decisive factor to boost the efficiency of durable production. This study deals with the optimization of perforated liner design for horizontal wells in Sarvak oil reservoir, which is located in the southwest of Iran. Sarvak is a carbonate oil reservoir, but it contains shale and mudstone. To avoid solid production and formation collapse, the screen liner was selected as a cost-effective solution. There were two choices, either perforated liner or slotted liner. The perforated liner was selected by finite element analysis and strength checking, which was proven by laboratory experiments. Sensitivity analysis was performed on various perforated parameters such as phase angle, hole density, hole diameter and hole distribution to determine the pattern of the holes so that enough strength of the liner was maintained while maintaining the maximum hole density. Then, parameters of perforated liner were determined by calculated loss of the flowing path, collapse resistance strength and tensile strength of casing pipes after perforated. As a result, hole density, hole size and perforated pattern were selected 100 HPM, 10 mm and 4-thread-line, respectively, in 4 ½” liner with 13.5 ppf. The ratio of the strength of the optimized perforated liner was less than 8% for collapse and 5% for tensile compared to the same specification casing.
A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase
Authors: Bayana Mary , Blacker A. John , Clayton Adam D. , Jolley Katherine E. , Labes Ricardo , Taylor Connor J. , Reynolds William 
Published: September 2020

AbstractDespite growing applications being reported both in academia and industry, continuous flow chemistry remains a relatively untaught field across most chemistry undergraduate courses. This is particularly true in laboratory practical classes, where it is often deemed simpler to carry out synthetic reactions in traditional batch mode using round-bottomed flasks. Herein, we report the development of an undergraduate project that utilises cheap and readily available materials to construct continuous flow reactors. The students compare the performance of different types of reactors and conditions in a biphasic selective acetylation of a symmetrical diamine. Throughout the investigation, the students can vary multiple parameters as they optimise the reaction, thus actively learning and readjusting them based on their improved understanding. The experiments give the students an appreciation of continuous flow techniques in comparison to batch.