1682 Feasibility of the exercise stress echocardiography for the evaluation of the right heart and pulmonary circulation unit in different clinical conditions: the right heart international network
Authors: Ferrara F , Gargani L , Guazzi M , D"alto M , Wierzbowska Drabik K , Argiento P , Cocchia R , Bandera F , Contaldi C , Lanero S , Russo V , Vriz O , D"andrea A , Kasprzak J D , Bossone E 
Published: January 2020

Abstract

Funding Acknowledgements
no funding sources exists

OnBehalf
RIGHT Heart International NETwork (RIGHT-NET)

Purpose
Exercise stress echocardiography (ESE) is a well-validated tool in ischemic and valvular heart diseases. The aim of this study is to assess the ESE feasibility for the evaluation of the right heart pulmonary circulation unit (RH-PCU) in a large cohort of subjects, from healthy individuals and elite athletes to patients with overt or at risk of developing pulmonary hypertension. Methods: 954 subjects [mean age 54.2 ± 16.4 years, 430 women] [254 healthy volunteers, 40 elite athletes, 363 patients with cardiovascular risk factors, 25 with pulmonary arterial hypertension, 149 with connective tissue diseases, 81 with left heart and valvular diseases, 42 with lung diseases], underwent standardized semi-recumbent cycle ergometer ESE with an incremental workload of 25 watts every 2 minutes up to symptom-limited maximal tolerated workload. ESE parameters of right heart structure, function and pressures were obtained according current recommendations. Results: The success rate for the evaluation of the RV function at peak exercise was 903/940 (96%) for tricuspid annular plane systolic excursion (TAPSE), 667/751 (89%) for tissue Doppler–derived tricuspid lateral annular systolic velocity (S’) and 425/772 (63%) for right ventricular fractional area change (RVFAC). Right ventricular–right atrial pressure gradient [RV-RA gradient = 4 x tricuspid regurgitation velocity2] was obtained in 894/954 patients (93.7 %) at rest and in 816/954 (85.5%) at peak exercise. At peak exercise, pulmonary acceleration time (AcT) was feasible among 435/545 (82.5%) patients (Table 1). Conclusions: In daily ESE monitoring of TAPSE and S’ resulted to be less challenging than of RV FAC. ESE was a feasible tool for the evaluation of RV-RA gradient and pulmonary AcT.
Table 1 Parameters Rest mean ± SD Peak mean ± SD P value Assessed n (%) Feasibility at rest n (%) Feasibility at peak n (%) RVED area (cm2) 17.4 ± 5.7 17.4 ± 5.8 0.9 672 632 (94.0) 425 (63.2) RVES area (cm2) 9.7 ± 4.3 9.6 ± 4.9 0.7 672 632 (94.0) 425 (63.2) TAPSE (mm) 22.9 ± 3.9 27.4 ± 5.5 &lt;0.001 940 922 (98.1) 903 (96.0) S’(cm/s) 13.1 ± 2.9 18.5 ± 5.0 &lt;0.001 751 746 (99.4) 667 (88.8) RVFAC (%) 45.7 ± 10 46.7 ± 11 0.121 672 632 (94.0) 425 (63.2) RV-RA gradient (mmHg) 24.3 ± 15 42.5 ± 20 &lt;0.001 954 894 (93.7) 816 (85.5) Pulmonary AcT (m/s) 129 ± 31 116 ± 35 &lt;0.001 545 527( 96.7) 435 (82.5) RVED, right ventricle end diastolic area; RVES, right ventricle end systolic area; p values indicate differences at rest and peak exercise. The term “assessed” indicates that an attempt was done in order to measure the parameter. The term “feasibility” indicates that it was possible to measure the parameter that was assessed.