bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using visibility analysis to improve point density and processing time of SfM‐MVS techniques for 3D reconstruction of landforms
Authors: Gómez‐Gutiérrez Álvaro , Biggs Trent , Gudino‐Elizondo Napoleon , Errea Paz , Alonso‐González Esteban , Nadal Romero Estela , de Sanjosé Blasco José Juan 
Published: May 2020

AbstractImage network geometry, including the number and orientation of images, impacts the error, coverage, and processing time of 3D terrain mapping performed using structure‐from‐motion and multiview‐stereo (SfM‐MVS). Few studies have quantified trade‐offs in error and processing time or ways to optimize image acquisition in diverse topographic conditions. Here, we determine suitable camera locations for image acquisition by minimizing the occlusion produced by topography. Viewshed analysis is used to select the suitable images, which requires a preliminary digital elevation model (DEM), potential camera locations, and sensor parameters. One aerial and two ground‐based image collections were used to analyse differences between SfM‐MVS models produced using: (1) all available images (ALL); (2) images selected using conventional methods (CON); and (3) images selected using the viewshed analysis (VIEW). The resulting models were compared with benchmark point clouds acquired by a terrestrial laser scanner (TLS) and TLS‐derived DEMs. The VIEW datasets produced denser point clouds (28–32% more points) and DEMs with up to 66% reduction in error compared with CON datasets due to reduction of gaps in the DEM. VIEW datasets reduced processing time by 37–76% compared with ALL, with no reduction in coverage or increase in error. DEMs produced with ALL and VIEW datasets had similar slope and roughness, while slight differences that may be locally important were observed for the CON dataset. The new method helps optimize SfM‐MVS image collection strategies that significantly reduce the number of images required with minimal loss in coverage or accuracy over complex surfaces. © 2020 John Wiley & Sons, Ltd.
Copigmentation effect of three phenolic acids on color and thermal stability of Chinese bayberry anthocyanins
Authors: Zhu Yanyun , Chen Hongji , Lou Leyan , Chen Yixin , Ye Xingqian , Chen Jianchu 
Published: May 2020

AbstractThe copigmentation effects of three phenolic acids (ferulic acid, sinapic acid, and syringic acid) on the color and thermal stability of Chinese bayberry anthocyanins were investigated. The three copigments of ferulic acid, sinapic acid, and syringic acid were found to have significant effects on the color enhancement of bayberry anthocyanins (p < .05). The maximum absorption wavelength of the anthocyanin aqueous solution exhibited a bathochromic shift, L* decreased, and a* increased with the increase in the molar ratio of copigments. The thermal stability of bayberry anthocyanins was significantly improved after copigmentation. No new anthocyanin derivatives appeared after copigmentation. The thermodynamic parameters (ΔG, ΔH, ΔS) of the three processes were all negative, indicating the three copigmentations were generally spontaneous and exothermic. The equilibrium constant (K) of the sinapic acid group was the greatest among the three phenolic acids, indicating that sinapic acid was more effective in stabilizing the anthocyanins.
Effects of medium‐ and long‐chain fatty acids on acetaminophen‐ or rifampicin‐induced hepatocellular injury
Authors: Yang Jun , Peng Ting , Huang Jiyong , Zhang Guohua , Xia Jiaheng , Ma Maomao , Deng Danwen , Gong Deming , Zeng Zheling 
Published: May 2020

AbstractDrug‐induced liver injury (DILI) is one of the common adverse effects of drug therapy, which is closely associated with oxidative stress, apoptosis, and inflammation response. Medium‐chain fatty acids (MCFA) were reported to relieve inflammation and attenuate oxidative stress. However, little has been known about the hepatoprotective effects of MCFA in DILI. In the present study, acetaminophen (AP) and rifampicin (RFP) were used to establish DILI models in LO2 cells, and the cytoprotective effects of MCFA on hepatocellular injury were investigated. Results showed that the optimal condition for the DILI model was treatment with 10 mM AP or 600 µM RFP for 24 hr. LCFA treatment markedly reduced the cell viability and increased the activities of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase. Meanwhile, LCFA treatment aggravated cell apoptosis, mitochondrial dysfunction, and oxidative stress. The mRNA and protein expression levels of inflammatory cytokines (IL‐1β and TNF‐α) were significantly elevated by LCFA. In contrast, MCFA treatment did not significantly affect cell viability, apoptosis, oxidative, stress and inflammation, and it did not produce the detrimental effects on DILI models. Therefore, we proposed that MCFA may be more safe and suitable than LCFA as nutrition support or the selection of daily dietary oil and fat for the patients with DILI.
Administration of Denosumab Preserves Bone Mineral Density at the Knee in Persons With Subacute Spinal Cord Injury: Findings From a Randomized Clinical Trial
Authors: Cirnigliaro Christopher M , La Fountaine Michael F , Parrott J Scott , Kirshblum Steven C , McKenna Cristin , Sauer Susan J , Shapses Sue A. , Hao Lihong , McClure Isa A , Hobson Joshua C , Spungen Ann M , Bauman William A 
Published: May 2020

ABSTRACTPersons with neurologically motor‐complete spinal cord injury (SCI) have a marked loss of bone mineral density (BMD) of the long bones of the lower extremities, predisposing them to fragility fractures, especially at the knee. Denosumab, a commercially available human monoclonal IgG antibody to receptor activator of nuclear factor‐κB ligand (RANKL), may provide an immunopharmacological solution to the rapid progressive deterioration of sublesional bone after SCI. Twenty‐six SCI participants with subacute motor‐complete SCI were randomized to receive either denosumab (60 mg) or placebo at baseline (BL), 6, and 12 months. Areal bone mineral density (aBMD) by dual energy x‐ray absorptiometry (DXA) at 18 months at the distal femur was the primary outcome and aBMD of the proximal tibia and hip were the secondary outcomes analyzed in 18 of the 26 participants (denosumab, n = 10 and placebo, n = 8). The metrics of peripheral QCT (pQCT) were the exploratory outcomes analyzed in a subsample of the cohort (denosumab, n = 7 and placebo n = 7). The mean aBMD (±95% CI) for the denosumab versus the placebo groups demonstrated a significant group × time interactions for the following regions of interest at BL and 18 months: distal femoral metaphysis = mean aBMD 1.187; 95% CI, 1.074 to 1.300 and mean aBMD 1.202; 95% CI, 1.074 to 1.329 versus mean aBMD 1.162; 95% CI, 0.962 to 1.362 and mean aBMD 0.961; 95% CI, 0.763 to 1.159, respectively (p < 0.001); distal femoral epiphysis = mean aBMD 1.557; 95% CI, 1.437 to 1.675 and mean aBMD 1.570; 95% CI, 1.440 to 1.700 versus mean aBMD 1.565; 95% CI, 1.434 to 1.696 and mean aBMD 1.103; 95% CI, 0.898 to 1.309, respectively (p = 0.002); and proximal tibial epiphysis = mean aBMD 1.071; 95% CI, 0.957 to 1.186 and mean aBMD 1.050; 95% CI, 0.932 to 1.168 versus mean aBMD 0.994; 95% CI, 0.879 to 1.109 and mean aBMD 0.760; 95% CI, 0.601 to 0.919, respectively (p < 0.001). Analysis of pQCT imaging revealed a continued trend toward significantly greater loss in total volumetric BMD (vBMD) and trabecular vBMD at the 4% distal tibia region, with a significant percent loss for total bone mineral content. Thus, at 18 months after acute SCI, our findings show that denosumab maintained aBMD at the knee region, the site of greatest clinical relevance in the SCI population. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice
Authors: Ieraci Alessandro , Barbieri Silvia S. , Macchi Chiara , Amadio Patrizia , Sandrini Leonardo , Magni Paolo , Popoli Maurizio , Ruscica Massimiliano 
Published: May 2020

AbstractObesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain‐derived neurotrophic factor (BDNF) Val66Met single‐nucleotide polymorphism (SNP) and obesity, although the underlying mechanisms of this connection are still not completely understood. In the present study, we found that homozygous knock‐in BDNFMet/Met mice were overweight and hyperphagic compared to wildtype BDNFVal/Val mice. Increased food intake was associated with reduction of total BDNF and BDNF1, BDNF4 and BDNF6 transcripts in the hypothalamus of BDNFMet/Met mice. In contrast, in the white adipose tissue total BDNF and Glut4 expression levels were augmented, while sirtuin 1 and leptin receptor (Ob‐R) expression levels were reduced in BDNFMet/Met mice. Moreover, plasmatic leptin levels were decreased in BDNFMet/Met mice. However, BDNFVal/Val and BDNFMet/Met mice showed a similar response to the insulin tolerance test and glucose tolerance test. Altogether, these results suggest that BDNF Val66Met SNP strongly contributes to adipose tissue pathophysiology, resulting in reduced circulating leptin levels and hypothalamic expression of BDNF, which, in turn, promote increased food intake and overweight in BDNFMet/Met mice.
New Zealand radiation therapists’ perceptions of peer group supervision as a tool to reduce burnout symptoms in the clinical setting
Authors: Dungey Gay , Neser Hazel , Sim Dalice 
Published: May 2020

AbstractIntroductionResearch indicates that radiation therapists (RTs) are at risk of burnout and that there is a lack of evidence on effective coping strategies for managing work‐related stressors within this workforce. Peer group supervision (PGS) is a useful tool in assisting staff to manage stress in the clinical setting, improve reflective practice and provide support. The aim of this research was to investigate New Zealand (NZ) RTs’ perceptions of participating in PGS.MethodsIn‐service training on PGS was offered to all RT centres in NZ, and five of the nine centres agreed to partake in PGS. Participants anonymously completed the same online questionnaire, six months apart. The questionnaire consisted of the Clinical Supervision Evaluation Questionnaire (CSEQ), an open‐ended question and demographics. The CSEQ asks participants to indicate their agreement with 14 statements related to Purpose, Process and Impact of PGS.ResultsOverall, 71 and 48 participants completed the first and second surveys, respectively. In contrast to previous studies, this study found that confidence in practice, team support and group safety were valued by participants. This was supported by the qualitative data that revealed four themes: supportive groups, time out to reflect, organisational barriers and group process issues. RTs with one to five years’ experience were more likely to structure their meetings, understand the purpose of the meetings and had clearer expectations of the group process.ConclusionsPGS may address burnout for RTs with one to five years’ experience. This group of RTs feel patient‐related matters can be discussed openly during PGS, and PGS appears to be helping to improve their practice and reduce stress. More experienced RTs appear to be using the groups as a ‘professional support group’, rather than ‘peer supervision’, as a strategy for managing organisational stressors associated with burnout.
Diverse activation patterns during persistent atrial fibrillation by noncontact charge‐density mapping of human atrium
Authors: Shi Rui , Chen Zhong , Butcher Charlie , Zaman Junaid AB , Boyalla Vennela , Wang Yi Kan , Riad Omar , Sathishkumar Anitha , Norman Mark , Haldar Shouvik , Jones David G , Hussain Wajid , Markides Vias , Wong Tom 
Published: May 2020

AbstractBackgroundGlobal simultaneous recording of atrial activation during atrial fibrillation (AF) can elucidate underlying mechanisms contributing to AF maintenance. A better understanding of these mechanisms may allow for an individualized ablation strategy to treat persistent AF. The study aims to characterize left atrial endocardial activation patterns during AF using noncontact charge‐density mapping.MethodsTwenty‐five patients with persistent AF were studied. Activation patterns were characterized into three subtypes: (i) focal with centrifugal activation (FCA); (ii) localized rotational activation (LRA); and (iii) localized irregular activation (LIA). Continuous activation patterns were analyzed and distributed in 18 defined regions in the left atrium.ResultsA total of 144 AF segments with 1068 activation patterns were analyzed. The most common pattern during AF was LIA (63%) which consists of four disparate features of activation: slow conduction (45%), pivoting (30%), collision (16%), and acceleration (7%). LRA was the second‐most common pattern (20%). FCA accounted for 17% of all activations, arising frequently from the pulmonary veins (PVs)/ostia. A majority of patients (24/25; 96%) showed continuous and highly dynamic patterns of activation comprising multiple combinations of FCA, LRA, and LIA, transitioning from one to the other without a discernible order. Preferential conduction areas were typically seen in the mid‐anterior (48%) and lower‐posterior (40%) walls.ConclusionAtrial fibrillation is characterized by heterogeneous activation patterns identified in PV‐ostia and non‐PV regions throughout the LA at varying locations between individuals. Clinical implications of individualized ablation strategies guided by charge‐density mapping need to be determined.
Better oral hygiene is associated with lower risk of stroke
Authors: Chang Yoonkyung , Woo Ho Geol , Lee Ji Sung , Song Tae‐Jin 
Published: May 2020

AbstractBackgroundPeriodontal disease or poor oral hygiene may lead to local infection, inflammation, and systemic inflammatory reactions, which are important mediators of development of stroke. We aimed to investigate the association of oral hygiene with risk of stroke in a nationwide population‐based cohort.MethodsFrom Korean National Health Insurance System‐Health Screening Cohort, 206,602 participants without missing data regarding demographic information, medical history, or blood/urine examination results were included. The presence of periodontal disease and indicators of oral hygiene, such as number of tooth brushings, dental visit history, dental scaling, and number of teeth loss and dental caries were evaluated. Occurrence of stroke including cerebral infarction, cerebral hemorrhage, and subarachnoid hemorrhage was defined as newly registration of International Classification of Diseases‐10 codes from I60 to I64 accompanying brain CT and/or MR examination at that time of diagnosis.ResultsThe 7337 (3.6%) cases of stroke including 5795 (79.0%) cases of cerebral infarction, 1568 (21.4%) cases of cerebral hemorrhage, and 621 (8.5%) cases of subarachnoid hemorrhage occurred during a median 10.4 years follow‐up. In multivariable analysis, frequent tooth brushing (≥3 times per day) was negatively associated with risk of stroke occurrence (hazard ratio [HR]: 0.78, 95% confidence interval [CI]: 0.73–0.84). Number of dental caries (≥4) was positively related to stroke occurrence (HR: 1.28, 95% CI: 1.13–1.44).ConclusionsRegular oral hygiene behavior was negatively, and infrequent oral hygiene care was positively associated with risk of occurrence for stroke, respectively. Brushing one's teeth three or more times daily may be associated with lower risk of stroke.
Clay Swelling Inhibition Using Novel Cationic Gemini Surfactants with Different Spacers
Authors: Murtaza Mobeen , Kamal Muhammad Shahzad , Hussain Syed M. S. , Mahmoud Mohamed 
Published: May 2020

AbstractHydration of shale formation by water‐based drilling fluids leads to several problems, such as the collapse of boreholes, tight holes, and stuck pipe, which may impede further drilling and time loss in rectifying the problems, leading to heavy economic losses. This study reports the development of new gemini cationic surfactants as shale‐swelling inhibitors. These gemini surfactants are structurally similar but differ in terms of the spacer group. Saturated butyl group (GS1) and unsaturated 2‐butenyl (GS2) and 2‐butynyl (GS3) were introduced as spacer groups of gemini surfactants. To assess the performance of new gemini cationic surfactants, two reliable clay sources were considered. The first clay is from an unconventional formation and the second clay is sodium bentonite. The inhibition characteristics of gemini surfactants were evaluated using dynamic swelling, hot rolling, rheology, and filtration experiments. Different formulations based on commercially available solutions for shale‐swelling inhibitors were applied and compared with cationic shale inhibitors. It was observed that the new gemini cationic surfactants with different spacers (saturated and unsaturated) reduced the shale swelling by different percentages. The GS2 surfactant, containing an unsaturated double bond proved to be a good swelling inhibitor as compared to GS1 and GS3. It also showed acceptable performance compared with the common shale inhibitor (KCl) used in the industry. The addition of surfactant has less impact on the rheological properties as compared to KCl. The filtration properties of the base mud were unchanged when surfactants were used. However, the commercial inhibitor, KCl, significantly increased the filtration volume that is associated with the disintegration of the clay. In summary, unlike commercial inhibitors, the synthesized surfactants reduced the clay swelling without affecting the other properties of the drilling fluids.
Analysis of Inflammatory Signaling in Human Middle Ear Cell Culture Models of Pediatric Otitis Media
Authors: Espahbodi Mana , Samuels Tina L. , McCormick Caroline , Khampang Pawjai , Yan Ke , Marshall Samuel , McCormick Michael E. , Chun Robert H. , Harvey Steven A. , Friedland David R. , Johnston Nikki , Kerschner Joseph E. 
Published: May 2020

Objectives/HypothesisCell culture models are valuable tools for investigation of the molecular pathogenesis of diseases including otitis media (OM). Previous study indicates that age‐, sex‐, and race‐associated differences in molecular signaling may impact disease pathophysiology. Currently, a singular immortalized middle ear epithelial (MEE) cell line exists, HMEEC‐1, derived from an adult without known middle ear disease. In this study, HMEEC‐1 and primary MEE cultures from pediatric patients with and without OM were stimulated with inflammatory cytokines or OM‐pathogenic bacterial lysates to examine differences in the response of molecules associated with OM pathogenesis.Study DesignCase–control series.MethodsMEE cultures were established from patients aged <6 years: two with recurrent OM (ROM), two with OM with effusion (OME), and one patient without OM who was undergoing cochlear implant surgery control undergoing cochlear implantation (Peds CI). Primary MEE cultures and HMEEC‐1 cells were stimulated with tumor necrosis factor‐α, interleukin (IL)‐1β, or nontypeable Haemophilus influenzae lysate. TNFA, IL1B, IL6, IL8, IL10, and MUC5B were assayed via quantitative polymerase chain reaction. IL‐8 was assayed by enzyme‐linked immunosorbent assay.ResultsGene/protein target expressions were frequently higher in pediatric OM lines than in HMEEC‐1 and Peds CI. HMEEC‐1 cells were frequently less responsive to stimuli than all pediatric lines. OME lines were often more responsive than ROM lines.ConclusionsOM may be associated with specific molecular phenotypes that are retained in primary cell culture. Adult‐derived HMEEC‐1 cells differ significantly in baseline expression and response of OM‐associated molecules relative to pediatric MEE cells. Work is underway to immortalize pediatric OM MEE cultures as improved tools for the OM research community.Level of Evidence4 Laryngoscope, 131:410–416, 2021
Imaging the breastfeeding swallow: Pilot study utilizing real‐time MRI
Authors: Mills Nikki , Lydon Anna‐Maria , Davies‐Payne David , Keesing Melissa , Geddes Donna T , Mirjalili Seyed Ali 
Published: May 2020

AbstractObjectiveKnowledge of the breastfeeding swallow is limited by practical challenges. Radiation exposure to both mother and infant and the radiolucent properties of breastmilk make videofluoroscopy an unsuitable imaging modality. Furthermore, ultrasound is not ideal for capturing the complex 3‐dimensional functional anatomy of swallowing. In this study we explore the feasibility of using real‐time MRI to capture the breastfeeding swallow.MethodsProspective observational study: Review of imaging from 12 normal infants (<5 months of age) and their mothers while breastfeeding using real‐time MRI.ResultsStatic images were successfully captured in 11 infants and dynamic images in nine infants. This imaging modality confirms the dorsal surface of the infant's tongue elevates the maternal nipple to the hard palate, closing the space around the nipple with no air visible in the oral cavity during sucking and swallowing. We obtained dynamic imaging of mandibular movement with sucking, palatal elevation and pharyngeal constriction with swallowing, diaphragm movement with breathing and milk entering the stomach. Breastmilk was easily visualized, being high intensity on T2 sequences. Technical challenges were encountered secondary to infant movement and difficulties acquiring and maintaining midsagittal orientation. The similarity in tissue densities of the lips, tongue, nipple and hard palate limited definition between these structures.ConclusionReal‐time MRI imaging was successful in capturing dynamic images of the breastfeeding swallow. However, technical and practical challenges make real‐time MRI unlikely at present to be suitable for swallow assessment in clinical practice. Advances in technology and expertise in dynamic image capture may improve the feasibility of using MRI to understand and assess the breastfeeding swallow in the near future.Level of evidence4.